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1 | 0 | Biomarker | C0079744 | Diffuse Large B-Cell Lymphoma | disease | DLBCL | 5291 | PIK3CB | PI3K | CTD_human | 21,173,233 | These results demonstrate a critical function of PI3K-PDK1 signaling upstream of MALT1 protease and NF-?B in distinct ABC DLBCL cells and provide a rationale for the pharmacologic use of PI3K inhibitors in DLBCL therapy. | 0.204121 | These results demonstrate a critical function of <span class="gene" id="21173233-6-49-53">PI3K</span>-PDK1 signaling upstream of MALT1 protease and NF-κB in distinct ABC DLBCL cells and provide a rationale for the pharmacologic use of <span class="gene" id="21173233-6-187-191">PI3K</span> inhibitors in <span class="disease" id="21173233-6-206-211">DLBCL</span> therapy. | CTD_human |
null | null | Negative | MESH:D013274 | null | null | GC | 439990 | null | LINC00857 | null | 28,042,329 | As a result, we identified five novel plasma lncRNAs (TINCR, CCAT2, AOC4P, BANCR and LINC00857), which, when combined in the lncRNA-based Index I, outperformed the CEA-based Index II (P < 0.001) and could distinguish GC patients from healthy controls with an area under the receiver-operating curve (AUC) of 0.91 (95% confidence interval (CI): 0.88-0.95). | null | null | null |
null | null | Negative | MESH:D003092 | null | null | colitis | 81897 | null | toll-like receptor 9 | null | 28,191,009 | Treatment with toll-like receptor 9 ligand CpG2216 significantly enhanced colitis in p47phox-/- mice, whereas tumor growth was simultaneously reduced. | null | null | null |
null | null | Negative | MESH:D017827 | null | null | wild type | 14768 | null | LanCL1 | null | 28,106,097 | Very similar concentrations of LK (0.5-2.5 nmol/g tissue) were found in LanCL1 knock-out, TKO and wild type (WT) mouse brains, suggesting that LanCL proteins are not involved in lanthionine biosynthesis. | null | null | null |
null | null | Negative | MESH:D009336 | null | null | necrosis | 22035 | null | TRAIL | null | 28,135,339 | The tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has been shown to induce apoptosis in a range of tumor cell types. | null | null | null |
1 | 0 | Therapeutic | C0574960 | Sacroiliitis | disease | sacroiliitis | 5443 | POMC | ACTH | CTD_human | 19,533,139 | We report a case of acute sacroiliitis with severe disability after only 3 weeks of isotretinoin therapy with graduate reduction of pain, limitation and muscle incompetence after discontinuation of the drug and ACTH-depo injection and Ethodolac therapy. | 0.2 | We report a case of acute <span class="disease" id="19533139-1-26-38">sacroiliitis</span> with severe disability after only 3 weeks of isotretinoin therapy with graduate reduction of pain, limitation and muscle incompetence after discontinuation of the drug and <span class="gene" id="19533139-1-211-215">ACTH</span>-depo injection and Ethodolac therapy. | CTD_human |
null | null | Negative | MESH:D013313 | null | null | PTSD | 382056 | null | mTORC1 | null | 28,043,916 | These results support the hypothesis that ketamine produces long-lasting mTORC1/protein synthesis and activity dependent effects on neuronal circuits that enhance the expression of extinction and could represent a novel approach for the treatment of PTSD. | null | null | null |
2 | 0 | Biomarker | C0036341 | Schizophrenia | disease | schizophrenia | 27185 | DISC1 | DISC1 | CTD_human | 20,531,374 | Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia. | 0.463891 | Association of <span class="gene" id="20531374-0-15-43">Disrupted in Schizophrenia 1</span> (<span class="gene" id="20531374-0-45-50">DISC1</span>) missense variants with ultra-resistant <span class="disease" id="20531374-0-91-104">schizophrenia</span>. | CTD_human |
null | null | Negative | MESH:D017827 | null | null | WT | 1432 | null | p38 | null | 28,155,010 | Western blot results showed that pIONL induced p38 but not JNK activation in the TG of WT mice. | null | null | null |
null | null | Negative | MESH:D009101 | null | null | multiple myeloma | 6962 | null | TCR | null | 28,053,195 | TCR-transduced T cells efficiently lysed primary B-cell leukemia, mantle cell lymphoma, and multiple myeloma in vitro. | null | null | null |
1 | 0 | Biomarker | C0039494 | Temporomandibular Joint Disorders | group | TMD | 1312 | COMT | COMT | CTD_human | 25,218,601 | Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced COMT activity, increased TMD risk, and increased musculoskeletal pain. | 0.207561 | Results show that the <span class="gene" id="25218601-3-22-26">COMT</span> rs4680 (val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced <span class="gene" id="25218601-3-180-184">COMT</span> activity, increased <span class="disease" id="25218601-3-205-208">TMD</span> risk, and increased musculoskeletal pain. | CTD_human |
null | null | Negative | MESH:D030342 | null | null | autosomal dominant disorder | 6926 | null | TBX3 | null | 28,145,909 | UNASSIGNED: Ulnar-mammary syndrome (UMS) is an autosomal dominant disorder resulting from TBX3 haploinsufficiency. | null | null | null |
null | null | Negative | MESH:D007951 | null | null | myeloid differentiation protein 2 | 21898 | null | Toll-like receptor 4 | null | 28,145,460 | UNASSIGNED: Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in sepsis due to infection with Gram-negative bacteria but not other microbes. | null | null | null |
1 | 0 | Biomarker | C0038220 | Status Epilepticus | disease | SE | 3315 | HSPB1 | Hsp25 | CTD_human | 20,971,094 | Interestingly, while Hsp32 and Hsp70 expression was transient, Hsp25 demonstrated a sustained induction pattern, which may reflect an additional role of Hsp25 in subsequent remodeling events in the days following SE. | 0.2 | Interestingly, while Hsp32 and Hsp70 expression was transient, <span class="gene" id="20971094-5-63-68">Hsp25</span> demonstrated a sustained induction pattern, which may reflect an additional role of <span class="gene" id="20971094-5-153-158">Hsp25</span> in subsequent remodeling events in the days following <span class="disease" id="20971094-5-213-215">SE</span>. | CTD_human |
null | null | Negative | MESH:D055752 | null | null | SCLC | 6317 | null | SCC | null | 28,022,171 | RESULTS: p characteristics: 51 males; median age, 59; 33 smokers, 26 ex-smokers; 49 adenocarcinoma, 10 large cell carcinoma (LCC), 18 squamous cell carcinoma (SCC), 8 SCLC. | null | null | null |
null | null | Negative | OMIM:132100 | null | null | photoparoxysmal EEG response | 100528023 | null | PPR | null | 28,042,998 | OBJECTIVE: To detect determinants for photoparoxysmal EEG response (PPR) in SCN1A-related Dravet syndrome (DS). | null | null | null |
3 | 0 | Biomarker | C0017638 | Glioma | disease | gliomas | 90 | ACVR1 | ACVR1 | CTD_human | 24,705,254 | Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. | 0.200275 | Genomic analysis of diffuse intrinsic pontine <span class="disease" id="24705254-0-46-53">gliomas</span> identifies three molecular subgroups and recurrent activating <span class="gene" id="24705254-0-116-121">ACVR1</span> mutations. | CTD_human |
1 | 0 | Biomarker | C0025202 | melanoma | disease | melanoma | 79852 | EPHX3 | ABHD9 | CTD_human | 16,778,180 | CGIs in putative promoter regions of 34 genes (ABHD9, BARHL1, CLIC5, CNNM1, COL2A1, CPT1C, DDIT4L, DERL3, DHRS3, DPYS, EFEMP2, FAM62C, FAM78A, FLJ33790, GBX2, GPR10, GPRASP1, HOXA9, HOXD11, HOXD12, HOXD13, p14ARF, PAX6, PRDX2, PTPRG, RASD1, RAX, REC8L1, SLC27A3, TGFB2, TLX2, TMEM22, TMEM30B, and UNC5C) were found to be methylated in at least 1 of 13 melanoma cell lines but not in two cultured normal melanocytes. | 0.2 | CGIs in putative promoter regions of 34 genes (<span class="gene" id="16778180-3-47-52">ABHD9</span>, BARHL1, CLIC5, CNNM1, COL2A1, CPT1C, DDIT4L, DERL3, DHRS3, DPYS, EFEMP2, FAM62C, FAM78A, FLJ33790, GBX2, GPR10, GPRASP1, HOXA9, HOXD11, HOXD12, HOXD13, p14ARF, PAX6, PRDX2, PTPRG, RASD1, RAX, REC8L1, SLC27A3, TGFB2, TLX2, TMEM22, TMEM30B, and UNC5C) were found to be methylated in at least 1 of 13 <span class="disease" id="16778180-3-352-360">melanoma</span> cell lines but not in two cultured normal melanocytes. | CTD_human |
null | null | Negative | MESH:D064146 | null | null | CT | 1956 | null | EGFR | null | 28,020,286 | Pre-operative CT also provides a unique opportunity to identify tumour markers predictive of response to CT and anti-EGFR therapy. | null | null | null |
1 | 0 | Biomarker | C0019163 | Hepatitis B | disease | hepatitis B | 1548 | CYP2A6 | CYP2A6 | CTD_human | 8,864,187 | In sections of liver infected with hepatitis B virus (HBV) or hepatitis C virus (HCV), the expression of CYP2A6 was markedly increased in hepatocytes immediately adjacent to areas of fibrosis and inflammation. | 0.2 | In sections of liver infected with <span class="disease" id="8864187-4-35-46">hepatitis B</span> virus (HBV) or hepatitis C virus (HCV), the expression of <span class="gene" id="8864187-4-105-111">CYP2A6</span> was markedly increased in hepatocytes immediately adjacent to areas of fibrosis and inflammation. | CTD_human |
null | null | Negative | MESH:C535607 | null | null | AGS | 8743 | null | TRAIL | null | 28,032,027 | Knock-down of VCP by siRNA enhanced sensitivity to TRAIL in AGS cells. | null | null | null |
null | null | Negative | MESH:C566610 | null | null | axis | 7329 | null | UBC9 | null | 28,143,738 | These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. | null | null | null |
null | null | Negative | MESH:D000690 | null | null | amyotrophic lateral sclerosis | 362965 | null | RanGap1 | null | 28,029,704 | Double immunofluorescent analyses revealed nuclear retention and apparent colocalization of RanGap1 with Nup205, Gp210 with Nup205, and partial colocalization of Nup205 with Nup107; most of the ischemic changes above were similar to those observed in patients with C9orf72-genetic amyotrophic lateral sclerosis. | null | null | null |
4 | 0 | Biomarker | C0020538 | Hypertensive disease | group | hypertension | 59272 | ACE2 | ACE2 | CTD_human | 17,473,847 | We conclude that the ACE2 T allele confers a high risk for hypertension and reduced antihypertensive response to ACE inhibitors. | 0.318481 | We conclude that the <span class="gene" id="17473847-6-21-25">ACE2</span> T allele confers a high risk for <span class="disease" id="17473847-6-59-71">hypertension</span> and reduced antihypertensive response to ACE inhibitors. | CTD_human |
null | null | Negative | MESH:D009336 | null | null | necrosis | 16193 | null | IL-6 | null | 28,031,106 | Concentrations of interleukin (IL)-10, IL-6, IL-1b and tumor necrosis factor (TNF)-a in sera were measured by ELISA. | null | null | null |
17 | 0 | Biomarker | C0020429 | Hyperalgesia | phenotype | hyperalgesia | 3827 | KNG1 | bradykinin | CTD_human | 16,259,764 | In addition, the ME of B. microstachya (3--300 mg kg(-1), i.p., 30 min earlier) inhibited, in a graded manner, the hyperalgesia induced by bradykinin (3.2 microg/paw), substance P (13.5 microg/paw), carrageenan (300 microg/paw), capsaicin (100 microg/paw) and adrenaline (100 ng/paw) in the rat paw, with mean ID50 values of 20.5, 17.9, 101.8, 54.2 and 99.7 mg kg(-1), respectively. | 0.280824 | In addition, the ME of B. microstachya (3--300 mg kg(-1), i.p., 30 min earlier) inhibited, in a graded manner, the <span class="disease" id="16259764-5-115-127">hyperalgesia</span> induced by <span class="gene" id="16259764-5-139-149">bradykinin</span> (3.2 microg/paw), substance P (13.5 microg/paw), carrageenan (300 microg/paw), capsaicin (100 microg/paw) and adrenaline (100 ng/paw) in the rat paw, with mean ID50 values of 20.5, 17.9, 101.8, 54.2 and 99.7 mg kg(-1), respectively. | CTD_human |
1 | 0 | Biomarker | C0036202 | Sarcoidosis | disease | sarcoidosis | 3123 | HLA-DRB1 | HLA-DRB1 | CTD_human | 14,508,706 | HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. | 0.472692 | <span class="gene" id="14508706-0-0-8">HLA-DRB1</span>*1101: a significant risk factor for <span class="disease" id="14508706-0-45-56">sarcoidosis</span> in blacks and whites. | CTD_human;ORPHANET |
null | null | Negative | MESH:C535468 | null | null | Copper deficiency | 1356 | null | ceruloplasmin | null | 28,118,841 | Copper deficiency, which leads to a defect in ceruloplasmin enzymatic activity, has a strong effect on iron homeostasis resulting in cellular iron retention. | null | null | null |
69 | 0 | Biomarker | C0020538 | Hypertensive disease | group | hypertension | 183 | AGT | angiotensin II | CTD_human | 17,989,111 | Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension. | 0.52 | Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during <span class="gene" id="17989111-0-107-121">angiotensin II</span>-induced <span class="disease" id="17989111-0-130-142">hypertension</span>. | CTD_human |
null | null | Negative | MESH:D002575 | null | null | CSM | 729 | null | C2-7 | null | 28,168,336 | CONCLUSIONS: Cervical alignment was compromised after laminoplasty in patients with CSM, and the degree of LCL was associated with preoperative T1 slope, C2-7 SVA, and CVLL. | null | null | null |
null | null | Negative | MESH:D007896 | null | null | leishmaniasis | 16176 | null | IL-1b | null | 28,192,528 | Using murine models of inflammation induced by the protozoan parasite leishmania, and data obtained from patients with cutaneous leishmaniasis, we uncovered a previously unrecognized role for NLRP3 inflammasome activation and IL-1b release as a detrimental consequence of CD8+ T cell-mediated cytotoxicity, ultimately resulting in chronic inflammation. | null | null | null |
null | null | Negative | MESH:D011225 | null | null | pre-eclampsia | 22095 | null | PET | null | 28,113,071 | OBJECTIVE: To determine whether fetuses in severe early onset pre-eclampsia (EO-PET) with or without intrauterine growth restriction has cardiac dysfunction across deteriorating stages of placental vascular resistance and whether this dysfunction influences perinatal outcome. | null | null | null |
1 | 0 | Biomarker | C0010346 | Crohn Disease | disease | CD | 151306 | GPBAR1 | TGR5 | CTD_human | 23,566,200 | Among LPMCs, isolated CD14(+) intestinal M?s from patients with CD expressed TGR5. | 0.2 | Among LPMCs, isolated CD14(+) intestinal M?s from patients with <span class="disease" id="23566200-10-64-66">CD</span> expressed <span class="gene" id="23566200-10-77-81">TGR5</span>. | CTD_human |
1 | 0 | Therapeutic | C0027051 | Myocardial Infarction | disease | MI | 3816 | KLK1 | tissue kallikrein | CTD_human | 12,411,458 | Rats were subjected to coronary artery ligation to induce MI, and adenovirus carrying the human tissue kallikrein or luciferase gene was injected into the tail vein at 1 week after surgery. | 0.201374 | Rats were subjected to coronary artery ligation to induce <span class="disease" id="12411458-2-58-60">MI</span>, and adenovirus carrying the human <span class="gene" id="12411458-2-96-113">tissue kallikrein</span> or luciferase gene was injected into the tail vein at 1 week after surgery. | CTD_human |
6 | 0 | Therapeutic | C0019243 | Angioedemas, Hereditary | disease | HAE | 710 | SERPING1 | C1-INH | CTD_human | 23,406,939 | C1-INH replacement and specific inhibition of plasma kallikrein with ecallantide have been successful in the treatment of hereditary angioedema (HAE), a more common related disorder. | 0.247499 | <span class="gene" id="23406939-2-0-6">C1-INH</span> replacement and specific inhibition of plasma kallikrein with ecallantide have been successful in the treatment of <span class="disease" id="23406939-2-122-143">hereditary angioedema</span> (<span class="disease" id="23406939-2-145-148">HAE</span>), a more common related disorder. | CTD_human |
null | null | Negative | MESH:D015458 | null | null | splenic T | 66889 | null | GRAIL | null | 28,114,324 | CD4 T cell proliferation was assessed by CFSE staining, and the expression of GRAIL in splenic T cells was measured by real-time PCR, flow cytometry and Western blot. | null | null | null |
null | null | Negative | MESH:D009362 | null | null | metastasis | 644914 | null | p21 | null | 28,014,849 | UNASSIGNED: 3109 Background: The ubiquitinin-proteosome proteolytic pathway regulates the metabolism of critical proteins involved in the cell cycle, apoptosis and metastasis such as p53, p21, p27 and NFkB. | null | null | null |
null | null | Negative | MESH:C580335 | null | null | NM | 3460 | null | AF 1 | null | 28,067,364 | In particular, it has been proposed that the phase is actually composed of two phases, a low-pressure AF 1 phase and a higher pressure NM 0 phase [Crespo et al., Proc. | null | null | null |
1 | 0 | Biomarker | C0017638 | Glioma | disease | glioma | 7124 | TNF | TNF-? | CTD_human | 22,199,285 | Resveratrol reduces TNF-?-induced U373MG human glioma cell invasion through regulating NF-?B activation and uPA/uPAR expression. | 0.22059 | Resveratrol reduces <span class="gene" id="22199285-0-20-25">TNF-α</span>-induced U373MG human <span class="disease" id="22199285-0-47-53">glioma</span> cell invasion through regulating NF-κB activation and uPA/uPAR expression. | CTD_human |
3 | 0 | Therapeutic | C0012739 | Disseminated Intravascular Coagulation | disease | DIC | 462 | SERPINC1 | antithrombin III | CTD_human | 9,637,888 | He was then given heparin and antithrombin III, and his DIC symptoms improved soon thereafter. | 0.200824 | He was then given heparin and <span class="gene" id="9637888-3-30-46">antithrombin III</span>, and his <span class="disease" id="9637888-3-56-59">DIC</span> symptoms improved soon thereafter. | CTD_human |
null | null | Negative | MESH:C536751 | null | null | WT | 24068 | null | SR-A1 | null | 28,193,223 | METHODS: To test this hypothesis, C57BL/6 WT and SR-A1 KO mice were nasally instilled with 50 g/mL of SPD-MAA for 3 weeks (wks). | null | null | null |
null | null | Negative | MESH:C563010 | null | null | neutrophilia | 644914 | null | p21 | null | 28,020,562 | CONCLUSIONS: Our experience suggests the utility of de HIF1a, CAIX, PTEN, p21, thrombocytosis and neutrophilia as prognostic factors in patients with advanced RCC. | null | null | null |
null | null | Negative | MESH:D003920 | null | null | diabetes mellitus | 24185 | null | Akt | null | 28,142,314 | CONTEXT: Metformin attenuates type-2 diabetes mellitus (T2DM)-induced hepatic dysfunction and altered PI3K/Akt/GLUT-4 signalling in experimental studies. | null | null | null |
1 | 0 | Biomarker | C0009324 | Ulcerative Colitis | disease | ulcerative colitis | 64127 | NOD2 | NOD2 | CTD_human | 20,452,301 | The present study was aimed at describing expression of innate immunity genes (NOD2, RIP2, ?-defensins HD5 and HD6) in inflamed colon and in ileum of children with ulcerative colitis. | 0.315643 | The present study was aimed at describing expression of innate immunity genes (<span class="gene" id="20452301-2-79-83">NOD2</span>, RIP2, α-defensins HD5 and HD6) in inflamed colon and in ileum of children with <span class="disease" id="20452301-2-164-182">ulcerative colitis</span>. | CTD_human |
null | null | Negative | MESH:C535575 | null | null | head and neck squamous cell carcinoma | 20848 | null | STAT3 | null | 28,138,036 | Signal transducer and activator of transcription 3 (STAT3) is involved in the tumor growth and metastasis of human head and neck squamous cell carcinoma (HNSCC) and is therefore a target with therapeutic potential. | null | null | null |
null | null | Negative | MESH:D008080 | null | null | LPS | 406937 | null | miR-145 | null | 28,036,291 | Here, we evaluated miR-155, miR-21, miR-143, miR-145 and miR-451 that are implicated in LPS, as novel FFPE tissue biomarkers.A total of 83 FFPE tissue specimens from primary LPS and lipomas (LPM) were analyzed. | null | null | null |
1 | 0 | Biomarker | C0014549 | Tonic-Clonic Epilepsy | disease | tonic-clonic convulsions | 627 | BDNF | BDNF | CTD_human | 16,023,256 | At 4 h following pilocarpine-induced seizures, expression of NGF, BDNF, HB-EGF, and FGF-2 increased only in the mice manifesting tonic-clonic convulsions and not in mice without seizures. | 0.2 | At 4 h following pilocarpine-induced seizures, expression of NGF, <span class="gene" id="16023256-5-66-70">BDNF</span>, HB-EGF, and FGF-2 increased only in the mice manifesting <span class="disease" id="16023256-5-129-153">tonic-clonic convulsions</span> and not in mice without seizures. | CTD_human |
null | null | Negative | MESH:D011502 | null | null | energy balance dysregulation | 57084 | null | vesicular glutamate transporter 2 | null | 28,077,715 | Here, we used neuroanatomical tracing, immunofluorescence, and confocal imaging to demonstrate that virtually all NTS > lPBN and lPBN > CeA CGRP projections coexpress vesicular glutamate transporter 2 (VGLUT2), providing evidence that excitatory projections mediate cisplatin-induced energy balance dysregulation. | null | null | null |
null | null | Negative | MESH:D004342 | null | null | delayed type hypersensitivity | 13866 | null | HER-2 | null | 28,022,330 | A secondary outcome was delayed type hypersensitivity (DTH) to the MHC Class II HER-2 epitopes p369 and p776. | null | null | null |
null | null | Negative | MESH:D064420 | null | null | cytotoxicity | 16176 | null | IL-1b | null | 28,192,528 | Using murine models of inflammation induced by the protozoan parasite leishmania, and data obtained from patients with cutaneous leishmaniasis, we uncovered a previously unrecognized role for NLRP3 inflammasome activation and IL-1b release as a detrimental consequence of CD8+ T cell-mediated cytotoxicity, ultimately resulting in chronic inflammation. | null | null | null |
null | null | Negative | MESH:D020295 | null | null | Stemness | 4072 | null | EpCAM | null | 28,114,366 | Stemness features of tumoral hepatocytes (EpCAM, K19, Oct3/4, c-KIT, c-MET, and CD133), and tumor stromal cells expressing a-smooth muscle actin (a-SMA), CD68, CD163, and IL-6 were analyzed in 36 low grade dysplastic nodules (DNs), 48 high grade DNs, 30 early HCCs (eHCCs), and 51 progressed HCCs (pHCCs) by immunohistochemistry or real-time PCR. | null | null | null |
null | null | Negative | MESH:D006528 | null | null | HCC | 14711 | null | Glycine N-methyltransferase | null | 28,205,209 | Glycine N-methyltransferase (GNMT) is downregulated in almost all HCC and its gene knockout mice developed HCC with high penetrance. | null | null | null |
null | null | Negative | MESH:D005910 | null | null | glioma | 100886964 | null | PTCSC3 | null | 28,187,755 | However, the biological function and molecular mechanism of lncRNA PTCSC3 in glioma are still unknown. | null | null | null |
null | null | Negative | MESH:D012640 | null | null | seizures | 24772 | null | SDF-1 | null | 28,104,461 | We examined whether the enhanced neurogenesis and improved cognitive functions induced by EE following seizures were mediated by SDF-1/CXCR4 pathway. | null | null | null |
null | null | Negative | MESH:C562390 | null | null | aqueous humor | 24835 | null | TNF-a | null | 28,112,125 | The serum and aqueous humor (AH) TNF-a, interleukin (IL)-6, and IL-10 levels were measured by ELISA at 4, 24, and 72 h post-LPS injection. | null | null | null |
1 | 0 | Biomarker | C0004352 | Autistic Disorder | disease | autistic | 3569 | IL6 | IL-6 | CTD_human | 8,964,908 | Since autoimmune response involves immune activation, the plasma levels of interferon-alpha (IFN-alpha), interferon-gamma (IFN-gamma), interleukin-12 (IL-12), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and soluble intercellular adhesion molecule-1 (sICAM-1) were measured in autistic patients and age-matched normal controls. | 0.200549 | Since autoimmune response involves immune activation, the plasma levels of interferon-alpha (IFN-alpha), interferon-gamma (IFN-gamma), interleukin-12 (IL-12), <span class="gene" id="8964908-2-159-172">interleukin-6</span> (<span class="gene" id="8964908-2-174-178">IL-6</span>), tumor necrosis factor-alpha (TNF-alpha), and soluble intercellular adhesion molecule-1 (sICAM-1) were measured in <span class="disease" id="8964908-2-295-303">autistic</span> patients and age-matched normal controls. | CTD_human |
1 | 0 | Biomarker | C0004096 | Asthma | disease | airway hyperreactivity | 4843 | NOS2 | NOS2 | CTD_human | 19,800,904 | We found that administration of nor-NOHA significantly decreased airway hyperreactivity and eosinophilic airway inflammation in ovalbumin-exposed C57BL/6 mice, but these parameters were unchanged in ovalbumin-exposed NOS2-/- mice. | 0.230766 | We found that administration of nor-NOHA significantly decreased <span class="disease" id="19800904-5-65-87">airway hyperreactivity</span> and eosinophilic airway inflammation in ovalbumin-exposed C57BL/6 mice, but these parameters were unchanged in ovalbumin-exposed <span class="gene" id="19800904-5-217-221">NOS2</span>-/- mice. | CTD_human |
null | null | Negative | MESH:C563010 | null | null | neutrophilia | 23476 | null | BRD4 | null | 28,077,651 | We also find that BRD4 independently regulates CDK9/phospho-Ser 2 CTD RNA Pol II recruitment to the IRF3-dependent IFN-stimulated genes (ISGs).<i>In vivo</i>, poly(I C)-induced neutrophilia and mucosal chemokine production are blocked by a small-molecule BRD4 bromodomain inhibitor. | null | null | null |
5 | 0 | Biomarker | C0919267 | ovarian neoplasm | disease | ovarian tumours | 672 | BRCA1 | BRCA1 | CTD_human | 7,795,652 | Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. | 0.382528 | Somatic mutations in the <span class="gene" id="7795652-0-25-30">BRCA1</span> gene in sporadic <span class="disease" id="7795652-0-48-63">ovarian tumours</span>. | CTD_human |
2 | 0 | Therapeutic | C0040822 | Tremor | phenotype | tremor | 7200 | TRH | TRH | CTD_human | 416,961 | Similarly, of these peptides only TRH and MK-771 induced a tremor of the forepaws in pentobarbital-anesthetized mice. | 0.2 | Similarly, of these peptides only <span class="gene" id="416961-3-34-37">TRH</span> and MK-771 induced a <span class="disease" id="416961-3-59-65">tremor</span> of the forepaws in pentobarbital-anesthetized mice. | CTD_human |
6 | 4 | Biomarker | C0010346 | Crohn Disease | disease | Crohn's disease | 64127 | NOD2 | CARD15 | CTD_human | 18,371,140 | NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease. | 0.52 | <span class="gene" id="18371140-0-0-4">NOD2</span>/<span class="gene" id="18371140-0-5-11">CARD15</span> gene variants are linked to failure of antibiotic treatment in perianal fistulating <span class="disease" id="18371140-0-96-111">Crohn's disease</span>. | CTD_human |
1 | 0 | Biomarker | C0014556 | Epilepsy, Temporal Lobe | disease | TLE | 2914 | GRM4 | mGluR4 | CTD_human | 15,694,259 | Here, we examine the transcription levels of mGluRs class I (mGluR1 and 5) and III (mGluR4 and 7) in experimental TLE and correlate differential mGluR subunit expression with mouse-strain-dependent susceptibility to TLE induced by pilocarpine. | 0.2 | Here, we examine the transcription levels of mGluRs class I (mGluR1 and 5) and III (<span class="gene" id="15694259-6-84-90">mGluR4</span> and 7) in experimental <span class="disease" id="15694259-6-114-117">TLE</span> and correlate differential mGluR subunit expression with mouse-strain-dependent susceptibility to <span class="disease" id="15694259-6-216-219">TLE</span> induced by pilocarpine. | CTD_human |
null | null | Negative | MESH:D004194 | null | null | early disease | 2026 | null | neuron-specific enolase | null | 28,127,669 | In all patients, early disease stage, good ECOG, normal neuron-specific enolase (NSE), thoracic radiotherapy, >= 4 cycles of chemotherapy, prophylactic cranial irradiation, good response to initial therapy were independent favorable prognostic factors for OS, along with gender, age, CEA and CA125. | null | null | null |
null | null | Negative | MESH:D002292 | null | null | RCC tumor | 20344 | null | P-selectin | null | 28,104,442 | Pharmacologic inhibition or knockdown of endothelial P-selectin blocks EP4-mediated cancer cell TEM, and inhibition of P-selectin prevents RCC tumor intravasation in CAM assay. | null | null | null |
1 | 0 | Biomarker | C0022661 | Kidney Failure, Chronic | disease | CRF | 1374 | CPT1A | CPT1A | CTD_human | 19,878,707 | CRF resulted in hypertension, proteinuria, renal tissue lipid accumulation, up-regulation of scavenger receptor A1 (SR-A1), acyl-CoA cholesterol acyltransferase-1 (ACAT1), carbohydrate-responsive element binding protein (ChREBP), fatty acid synthase (FAS), acyl-CoA carboxylase (ACC), liver X receptor (LXR), ATP binding cassette (ABC) A-1, ABCG-1, and SR-B1 and down-regulation of sterol responsive element binding protein-1 (SREBP-1), SREBP-2, HMG-CoA reductase, PPAR-alpha, fatty acid binding protein (L-FABP), and CPT1A. | 0.200275 | <span class="disease" id="19878707-5-0-3">CRF</span> resulted in hypertension, proteinuria, renal tissue lipid accumulation, up-regulation of scavenger receptor A1 (SR-A1), acyl-CoA cholesterol acyltransferase-1 (ACAT1), carbohydrate-responsive element binding protein (ChREBP), fatty acid synthase (FAS), acyl-CoA carboxylase (ACC), liver X receptor (LXR), ATP binding cassette (ABC) A-1, ABCG-1, and SR-B1 and down-regulation of sterol responsive element binding protein-1 (SREBP-1), SREBP-2, HMG-CoA reductase, PPAR-alpha, fatty acid binding protein (L-FABP), and <span class="gene" id="19878707-5-518-523">CPT1A</span>. | CTD_human |
2 | 0 | Biomarker | C0004903 | Beckwith-Wiedemann Syndrome | disease | Beckwith-Wiedemann syndrome | 3481 | IGF2 | insulin-like growth factor 2 | CTD_human | 8,252,039 | Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome. | 0.222737 | Disruption of <span class="gene" id="8252039-0-14-42">insulin-like growth factor 2</span> imprinting in <span class="disease" id="8252039-0-57-84">Beckwith-Wiedemann syndrome</span>. | CTD_human |
null | null | Negative | MESH:D003920 | null | null | diabetic | 22339 | null | VEGF | null | 28,091,556 | However, the contribution and mechanism of VEGF-B in diabetic peripheral neuropathy remains unclear. | null | null | null |
1 | 0 | Biomarker | C0027794 | Neural Tube Defects | group | NTD | 635 | BHMT | BHMT | CTD_human | 17,035,141 | In 304 Caucasian American NTD families with myelomeningocele or anencephaly, we examined 28 polymorphisms in 11 genes: folate receptor 1, folate receptor 2, solute carrier family 19 member 1, transcobalamin II, methylenetetrahydrofolate dehydrogenase 1, serine hydroxymethyl-transferase 1, 5,10-methylenetetrahydrofolate reductase (MTHFR), 5-methyltetrahydrofolate-homo-cysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase, betaine-homocysteine methyltransferase (BHMT), and cystathionine-beta-synthase. | 0.202956 | In 304 Caucasian American <span class="disease" id="17035141-4-26-29">NTD</span> families with myelomeningocele or anencephaly, we examined 28 polymorphisms in 11 genes: folate receptor 1, folate receptor 2, solute carrier family 19 member 1, transcobalamin II, methylenetetrahydrofolate dehydrogenase 1, serine hydroxymethyl-transferase 1, 5,10-methylenetetrahydrofolate reductase (MTHFR), 5-methyltetrahydrofolate-homo-cysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase, <span class="gene" id="17035141-4-465-503">betaine-homocysteine methyltransferase</span> (<span class="gene" id="17035141-4-505-509">BHMT</span>), and cystathionine-beta-synthase. | CTD_human |
null | null | Negative | MESH:D009136 | null | null | muscular dystrophy | 26092 | null | TOR1AIP1 | null | 28,110,863 | A recently identified muscular dystrophy gene TOR1AIP1 was detected as a hub gene in dysferlinopathy. | null | null | null |
null | null | Negative | MESH:C564145 | null | null | HBD-2 | 7124 | null | tumor necrosis factor | null | 28,147,379 | Concentrations of pro- and anti-inflammatory mediators (interleukin [IL]-1b, IL-6, tumor necrosis factor [TNF]-a, IL-10, and TGF-b), chemokines (IL-8 and GCP-2), and human b-defensins (HBD-1, HBD-2, and HBD-3) were measured in the culture supernatants. | null | null | null |
null | null | Negative | MESH:D053448 | null | null | prostate specific antigen | 26872 | null | STEAP1 | null | 28,023,416 | UNASSIGNED: 4535 Background: CV9103 is a prostate cancer (PCA) vaccine that contains the four antigens PSA (prostate specific antigen), PSCA, PSMA and STEAP1 as self-adjuvanted full-length mRNAs. | null | null | null |
null | null | Negative | MESH:D001919 | null | null | bradycardia | 28938 | null | l-1 | null | 28,067,629 | There was a varying extent of bradycardia and ventricular contractile impairment with different anesthetic drugs and doses, with tricaine 0.75 mmol l-1 having a relatively more favorable profile. | null | null | null |
4 | 0 | Biomarker | C0003469 | Anxiety Disorders | group | anxiety | 135 | ADORA2A | adenosine A2A receptor | CTD_human | 16,118,787 | Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants. | 0.205154 | Interindividual variation in <span class="disease" id="16118787-0-29-36">anxiety</span> response to amphetamine: possible role for <span class="gene" id="16118787-0-80-102">adenosine A2A receptor</span> gene variants. | CTD_human |
1 | 0 | Biomarker | C0025202 | melanoma | disease | melanoma | 26507 | CNNM1 | CNNM1 | CTD_human | 16,778,180 | CGIs in putative promoter regions of 34 genes (ABHD9, BARHL1, CLIC5, CNNM1, COL2A1, CPT1C, DDIT4L, DERL3, DHRS3, DPYS, EFEMP2, FAM62C, FAM78A, FLJ33790, GBX2, GPR10, GPRASP1, HOXA9, HOXD11, HOXD12, HOXD13, p14ARF, PAX6, PRDX2, PTPRG, RASD1, RAX, REC8L1, SLC27A3, TGFB2, TLX2, TMEM22, TMEM30B, and UNC5C) were found to be methylated in at least 1 of 13 melanoma cell lines but not in two cultured normal melanocytes. | 0.2 | CGIs in putative promoter regions of 34 genes (ABHD9, BARHL1, CLIC5, <span class="gene" id="16778180-3-69-74">CNNM1</span>, COL2A1, CPT1C, DDIT4L, DERL3, DHRS3, DPYS, EFEMP2, FAM62C, FAM78A, FLJ33790, GBX2, GPR10, GPRASP1, HOXA9, HOXD11, HOXD12, HOXD13, p14ARF, PAX6, PRDX2, PTPRG, RASD1, RAX, REC8L1, SLC27A3, TGFB2, TLX2, TMEM22, TMEM30B, and UNC5C) were found to be methylated in at least 1 of 13 <span class="disease" id="16778180-3-352-360">melanoma</span> cell lines but not in two cultured normal melanocytes. | CTD_human |
null | null | Negative | MESH:D001008 | null | null | anxiety | 314322 | null | c-Fos | null | 28,049,558 | Relative to RHA rats, RLA rats exhibit enhanced anxiety/fearfulness, augmented hippocampal/amygdala c-Fos expression following exposure to novelty/conflict, increased hippocampal neuronal density and higher endocrine responses to stress. | null | null | null |
null | null | Negative | MESH:D001943 | null | null | MBC | 13866 | null | HER-2 | null | 28,022,330 | Here, we test the hypothesis that CY-modulated vaccination with weekly Trastuzumab (T) can induce clinically-relevant HER-2-specific immunity in HER-2+ MBC patients. | null | null | null |
null | null | Negative | MESH:D003240 | null | null | connective tissue disorder | 1281 | null | COL3A1 | null | 28,183,226 | Vascular Ehlers-Danlos syndrome (vEDS) is a rare and severe connective tissue disorder caused by mutations in the collagen type III alpha I chain ( COL3A1) gene. | null | null | null |
1 | 0 | Biomarker | C0038356 | Stomach Neoplasms | group | gastric tumors | 116135 | LRRC3B | LRRC3B | CTD_human | 18,757,430 | Pyrosequencing analysis of the promoter region revealed that LRRC3B was significantly hypermethylated in gastric tumors. | 0.203008 | Pyrosequencing analysis of the promoter region revealed that <span class="gene" id="18757430-5-61-67">LRRC3B</span> was significantly hypermethylated in <span class="disease" id="18757430-5-105-119">gastric tumors</span>. | CTD_human |
null | null | Negative | MESH:D009369 | null | null | cancer | 3438 | null | IFN-a | null | 28,022,317 | METHODS: Patients with renal cancer and requiring first-line treatment for metastatic disease were randomized 1:1 to receive MVA-5T4 or placebo alongside Sunitinib, IL-2 or IFN-a in a multi-centre phase III trial. | null | null | null |
69 | 0 | Therapeutic | C0020538 | Hypertensive disease | group | hypertension | 183 | AGT | angiotensin II | CTD_human | 18,420,994 | Administration of resveratrol suppressed AT1R expression in the mouse aorta and blunted angiotensin II-induced hypertension. | 0.52 | Administration of resveratrol suppressed AT1R expression in the mouse aorta and blunted <span class="gene" id="18420994-9-88-102">angiotensin II</span>-induced <span class="disease" id="18420994-9-111-123">hypertension</span>. | CTD_human |
3 | 0 | Biomarker | C0220633 | Uveal melanoma | disease | uveal melanoma | 2767 | GNA11 | GNA11 | CTD_human | 22,733,540 | Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. | 0.408242 | Combination small molecule MEK and PI3K inhibition enhances <span class="disease" id="22733540-0-60-74">uveal melanoma</span> cell death in a mutant GNAQ- and <span class="gene" id="22733540-0-108-113">GNA11</span>-dependent manner. | CTD_human;ORPHANET |
null | null | Negative | MESH:D056486 | null | null | liver injury | 68585 | null | Nogo-B | null | 28,090,670 | Liver specimens from wild-type (WT) and Nogo-B knockout (KO) mice fed a control or Lieber-DeCarli ethanol liquid diet (5% ethanol) for 6 weeks were analyzed for liver injury and steatosis. | null | null | null |
null | null | Negative | MESH:D014552 | null | null | UTI | 54113 | null | VUR | null | 28,087,926 | The risk of renal scarring is highest in children under 1 year of age with febrile UTI and high-grade vesicoureteral reflux (VUR). | null | null | null |
null | null | Negative | MESH:D012640 | null | null | CRF | 46 | null | ACLS | null | 28,009,533 | Cardiovascular disease risk was determined using published age- and sex-adjusted values for low, moderate, and high CRF from the Aerobics Center Longitudinal Study (ACLS). | null | null | null |
1 | 0 | Biomarker | C0004096 | Asthma | disease | asthma | 632 | BGLAP | osteocalcin | CTD_human | 8,429,434 | Effects on bone formation were difficult to assess because asthma per se caused a significant reduction in osteocalcin, a sensitive marker of bone formation. | 0.2 | Effects on bone formation were difficult to assess because <span class="disease" id="8429434-11-59-65">asthma</span> per se caused a significant reduction in <span class="gene" id="8429434-11-107-118">osteocalcin</span>, a sensitive marker of bone formation. | CTD_human |
96 | 174 | Biomarker | C0019202 | Hepatolenticular Degeneration | disease | Wilson disease | 540 | ATP7B | Atp7b | CTD_human | 14,574,444 | The Long-Evans cinnamon (LEC) rat, an authentic model for Wilson disease, is characterized by a mutation in the Atp7b gene leading to a defective copper excretion and, as a consequence, to an accumulation of the metal in the liver and copper-associated hepatotoxicity. | 0.885769 | The Long-Evans cinnamon (LEC) rat, an authentic model for <span class="disease" id="14574444-1-58-72">Wilson disease</span>, is characterized by a mutation in the <span class="gene" id="14574444-1-112-117">Atp7b</span> gene leading to a defective copper excretion and, as a consequence, to an accumulation of the metal in the liver and copper-associated hepatotoxicity. | CTD_human;ORPHANET;UNIPROT |
96 | 174 | Biomarker | C0019202 | Hepatolenticular Degeneration | disease | WD | 540 | ATP7B | ATP7B | CTD_human | 22,677,543 | In 78 selected patients of the cohort with two mutations in ATP7B, we have examined genotype-phenotype correlation between the detected changes in Atox1 and COMMD1 genes, and the presentation of the WD patients. | 0.885769 | In 78 selected patients of the cohort with two mutations in <span class="gene" id="22677543-9-60-65">ATP7B</span>, we have examined genotype-phenotype correlation between the detected changes in Atox1 and COMMD1 genes, and the presentation of the <span class="disease" id="22677543-9-199-201">WD</span> patients. | CTD_human;ORPHANET;UNIPROT |
null | null | Negative | MESH:D017674 | null | null | Hypophosphatemia | 64654 | null | fibroblast growth factor 23 | null | 28,005,411 | Hypophosphatemia in ARHR results from increased circulating levels of the phosphaturic hormone, fibroblast growth factor 23 (FGF23). | null | null | null |
null | null | Negative | MESH:D009369 | null | null | tumor | 21926 | null | TNF | null | 28,013,186 | RESULTS: Treatment with PT or PO inhibited the secretion of interleukin (IL)-8 and tumor necrosis factor (TNF) in ethanol- or LPS-stimulated KATO III cells. | null | null | null |
null | null | Negative | MESH:D020370 | null | null | sedentary knee osteoarthritis | 5892 | null | TRAD | null | 28,108,936 | The objective of the present study was to compare a group-mediated cognitive behavioral (GMCB) physical activity intervention with traditional exercise therapy (TRAD) upon select social cognitive outcomes in sedentary knee osteoarthritis (knee OA) patients. | null | null | null |
null | null | Negative | MESH:D020191 | null | null | NOD | 3560 | null | CD122 | null | 28,164,571 | 1 x 107 SKM-1 cells were inoculated into anti-mouse CD122 monoantibody conditioned nonobese diabetic severe combined immunodeficiency (NOD/SCID) mice by intravenous injection. | null | null | null |
12 | 8 | Biomarker | C0795864 | Smith-Magenis syndrome | disease | SMS | 10743 | RAI1 | RAI1 | CTD_human | 19,236,431 | Validation using real-time quantitative reverse transcriptase polymerase chain reaction confirmed the gene expression profile of 75% of the selected genes analyzed in both HEK293T RAI1 knockdown cells and SMS lymphoblastoid cell lines. | 0.48989 | Validation using real-time quantitative reverse transcriptase polymerase chain reaction confirmed the gene expression profile of 75% of the selected genes analyzed in both HEK293T <span class="gene" id="19236431-7-180-184">RAI1</span> knockdown cells and <span class="disease" id="19236431-7-205-208">SMS</span> lymphoblastoid cell lines. | CTD_human;ORPHANET |
4 | 0 | Therapeutic | C0003873 | Rheumatoid Arthritis | disease | rheumatoid arthritis | 7124 | TNF | TNFalpha | CTD_human | 12,566,094 | Because interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNFalpha) are central to the progression of inflammation and joint tissue injury in patients with rheumatoid arthritis, we investigated human monocyte IL-1beta and TNFalpha responses after the addition of AjA to cells in vitro. | 0.50559 | Because interleukin-1beta (IL-1beta) and <span class="gene" id="12566094-2-41-68">tumor necrosis factor-alpha</span> (<span class="gene" id="12566094-2-70-78">TNFalpha</span>) are central to the progression of inflammation and joint tissue injury in patients with <span class="disease" id="12566094-2-168-188">rheumatoid arthritis</span>, we investigated human monocyte IL-1beta and <span class="gene" id="12566094-2-234-242">TNFalpha</span> responses after the addition of AjA to cells in vitro. | CTD_human |
1 | 0 | Biomarker | C0004352 | Autistic Disorder | disease | autism | 7133 | TNFRSF1B | tumor necrosis factor receptor II | CTD_human | 16,139,734 | In sera from 35 persons with autism, among cytokines, only tumor necrosis factor receptor II was elevated compared with controls (P < 0.02). | 0.2 | In sera from 35 persons with <span class="disease" id="16139734-4-29-35">autism</span>, among cytokines, only <span class="gene" id="16139734-4-59-92">tumor necrosis factor receptor II</span> was elevated compared with controls (P < 0.02). | CTD_human |
null | null | Negative | MESH:D030342 | null | null | autosomal recessive genetic disorder | 445 | null | argininosuccinate synthetase 1 | null | 28,132,756 | OBJECTIVES: Citrullinemia type 1 (CTLN1) is an autosomal recessive genetic disorder caused by mutations in the argininosuccinate synthetase 1 (ASS1) gene, which encodes for the argininosuccinate synthetase enzyme. | null | null | null |
6 | 0 | Therapeutic | C0019243 | Angioedemas, Hereditary | disease | HAE | 710 | SERPING1 | C1-INH | CTD_human | 23,634,741 | In the past, few treatment options were available; however, several new therapies with proven efficacy have recently become available to treat and prevent HAE attacks, such as plasma-derived and recombinant C1-INHs that replace the deficient protein, bradykinin receptor antagonist (icatibant) that blocks bradykinin activity and kallikrein inhibitor (ecallantide) that prevents bradykinin release. | 0.247499 | In the past, few treatment options were available; however, several new therapies with proven efficacy have recently become available to treat and prevent <span class="disease" id="23634741-4-155-158">HAE</span> attacks, such as plasma-derived and recombinant <span class="gene" id="23634741-4-207-213">C1-INH</span>s that replace the deficient protein, bradykinin receptor antagonist (icatibant) that blocks bradykinin activity and kallikrein inhibitor (ecallantide) that prevents bradykinin release. | CTD_human |
null | null | Negative | MESH:D006623 | null | null | VHL | 3091 | null | HIF1a | null | 28,143,140 | We experimentally validated VHL and HIF1a as likely direct targets of miR-17 and miR-224. | null | null | null |
1 | 0 | Biomarker | C0004114 | Astrocytoma | disease | astroglioma | 4314 | MMP3 | MMP-3 | CTD_human | 20,188,714 | In the present study, we found that glycitein, a bacterial metabolite of the isoflavone glycitin, inhibits the expression of MMP-3 and MMP-9 at promoter, mRNA, and protein levels in PMA-stimulated U87MG human astroglioma cells. | 0.203231 | In the present study, we found that glycitein, a bacterial metabolite of the isoflavone glycitin, inhibits the expression of <span class="gene" id="20188714-3-125-130">MMP-3</span> and MMP-9 at promoter, mRNA, and protein levels in PMA-stimulated U87MG human <span class="disease" id="20188714-3-209-220">astroglioma</span> cells. | CTD_human |
2 | 6 | Biomarker | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | disease | T2D | 6934 | TCF7L2 | TCF7L2 | CTD_human | 17,460,697 | We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 gene (TCF7L2) gene conferred the most significant risk. | 0.37913 | We conducted a genome-wide association study for <span class="disease" id="17460697-1-49-64">type 2 diabetes</span> (<span class="disease" id="17460697-1-66-69">T2D</span>) in Icelandic cases and controls, and we found that a previously described variant in the <span class="gene" id="17460697-1-160-189">transcription factor 7-like 2</span> gene (<span class="gene" id="17460697-1-196-202">TCF7L2</span>) gene conferred the most significant risk. | CTD_human |
null | null | Negative | MESH:D006470 | null | null | bleeding | 26193 | null | ND-1 | null | 28,097,150 | In this manuscript we reported a novel naphthalenic derivative compound ND-1 with potent antithrombotic effect and lower bleeding risk. | null | null | null |
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