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6 | 11 | Biomarker | C0917796 | Optic Atrophy, Hereditary, Leber | disease | Leber's hereditary optic neuropathy | 4535 | ND1 | ND1 | CTD_human | 15,505,787 | The ND1 gene of complex I is a mutational hot spot for Leber's hereditary optic neuropathy. | 0.612166 | The <span class="gene" id="15505787-0-4-7">ND1</span> gene of complex I is a mutational hot spot for <span class="disease" id="15505787-0-55-90">Leber's hereditary optic neuropathy</span>. | CTD_human;HPO;ORPHANET;UNIPROT |
null | null | Negative | MESH:D050197 | null | null | atherosclerosis | 11303 | null | ABCA1 | null | 28,069,546 | The results provide a strong rationale for G004 to be an efficient anti-atherosclerosis agent that improved vascular endothelial dysfunction by stimulating SIRT1/eNOS and promoted RCT by stimulating SIRT1/LXRa/ABCA1/G1. | null | null | null |
null | null | Negative | MESH:C563733 | null | null | carotid intima-media thickness | 404677 | null | CIMT | null | 28,137,492 | METHODS: We searched PUBMED, EMBASE for studies published before Aug 1st, 2016, on the association between COPD and carotid intima-media thickness (CIMT), prevalence of carotid plaques, flow-mediated dilation (FMD), pulse-wave velocity (PWV) and augmentation index (AIx). | null | null | null |
1 | 0 | Biomarker | C0598608 | Hyperhomocysteinemia | disease | hyperhomocysteinemia | 7124 | TNF | tumor necrosis factor-alpha | CTD_human | 12,615,666 | Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase. | 0.2 | Increased superoxide production in coronary arteries in <span class="disease" id="12615666-0-56-76">hyperhomocysteinemia</span>: role of <span class="gene" id="12615666-0-86-113">tumor necrosis factor-alpha</span>, NAD(P)H oxidase, and inducible nitric oxide synthase. | CTD_human |
1 | 1 | Biomarker | C0242383 | Age related macular degeneration | disease | AMD | 8797 | TNFRSF10A | TNFRSF10A | CTD_human | 21,909,106 | In addition to CFH (rs800292, P = 4.23 × 10(-15)) and ARMS2 (rs3750847, P = 8.67 × 10(-29)) loci, we identified two new susceptibility loci for exudative AMD: TNFRSF10A-LOC389641 on chromosome 8p21 (rs13278062, combined P = 1.03 × 10(-12), odds ratio = 0.73) and REST-C4orf14-POLR2B-IGFBP7 on chromosome 4q12 (rs1713985, combined P = 2.34 × 10(-8), odds ratio = 1.30). | 0.200824 | In addition to CFH (rs800292, P = 4.23 × 10(-15)) and ARMS2 (rs3750847, P = 8.67 × 10(-29)) loci, we identified two new susceptibility loci for exudative <span class="disease" id="21909106-3-154-157">AMD</span>: <span class="gene" id="21909106-3-159-168">TNFRSF10A</span>-LOC389641 on chromosome 8p21 (rs13278062, combined P = 1.03 × 10(-12), odds ratio = 0.73) and REST-C4orf14-POLR2B-IGFBP7 on chromosome 4q12 (rs1713985, combined P = 2.34 × 10(-8), odds ratio = 1.30). | CTD_human |
null | null | Negative | MESH:D005235 | null | null | non-alcoholic steatohepatitis | 19013 | null | PPARA | null | 28,077,274 | 2) Expression of PPARA in human liver is reduced in patients with non-alcoholic steatohepatitis or infected with the hepatitis C virus. | null | null | null |
15 | 12 | Biomarker | C0342549 | Familial Testotoxicosis | disease | peripheral precocious puberty | 3973 | LHCGR | LHCGR | CTD_human | 26,831,561 | We report here two patients who presented with peripheral precocious puberty and an activating mutation in the LHCGR gene: one with a family history and previously determined mutation and the other without family history and with a novel mutation (c.830G>T). | 0.608176 | We report here two patients who presented with <span class="disease" id="26831561-5-47-76">peripheral precocious puberty</span> and an activating mutation in the <span class="gene" id="26831561-5-111-116">LHCGR</span> gene: one with a family history and previously determined mutation and the other without family history and with a novel mutation (c.830G>T). | CTD_human;ORPHANET;UNIPROT |
1 | 0 | Biomarker | C0027627 | Neoplasm Metastasis | phenotype | metastasis | 5829 | PXN | paxillin | CTD_human | 18,492,274 | Transfection produced a modest reduction on metastatic potential, indicating that: i) paxillin plays a role as inducer of melanoma metastasis; and ii) paxillin downregulation is not sufficient to explain the antimetastatic effect of 4-HC. | 0.20467 | Transfection produced a modest reduction on metastatic potential, indicating that: i) <span class="gene" id="18492274-13-86-94">paxillin</span> plays a role as inducer of melanoma <span class="disease" id="18492274-13-131-141">metastasis</span>; and ii) <span class="gene" id="18492274-13-151-159">paxillin</span> downregulation is not sufficient to explain the antimetastatic effect of 4-HC. | CTD_human |
null | null | Negative | MESH:C562790 | null | null | HCA2 | 3569 | null | IL-6 | null | 28,186,140 | We found that proinflammatory stimulants LPS, IL-6 and IL-1b up-regulated the expression of HCA2 on macrophages. | null | null | null |
null | null | Negative | MESH:C537409 | null | null | X-linked agammaglobulinemia | 7097 | null | TLR2 | null | 28,095,323 | Altered TLR responses to TLR2 and 4 agonists are seen in chronic granulomatous disease (CGD) and X-linked agammaglobulinemia (XLA). | null | null | null |
1 | 0 | Biomarker | C0034067 | Pulmonary Emphysema | disease | emphysema | 3694 | ITGB6 | Itgb6 | CTD_human | 12,634,787 | Here we report that Itgb6-null mice develop age-related emphysema that is completely abrogated either by transgenic expression of versions of the beta6 integrin subunit that support TGF-beta activation, or by the loss of Mmp12. | 0.200824 | Here we report that <span class="gene" id="12634787-4-20-25">Itgb6</span>-null mice develop age-related <span class="disease" id="12634787-4-56-65">emphysema</span> that is completely abrogated either by transgenic expression of versions of the beta6 integrin subunit that support TGF-beta activation, or by the loss of Mmp12. | CTD_human |
null | null | Negative | MESH:D014929 | null | null | Wolfram syndrome | 493856 | null | Miner1 | null | 28,082,676 | Miner2 is a member of a new CDGSH iron-sulfur protein family that also includes two mitochondrial proteins: the type II diabetes-related mitoNEET and the Wolfram syndrome 2-linked Miner1. | null | null | null |
1 | 0 | Biomarker | C0007192 | Cardiomyopathy, Alcoholic | disease | alcoholic cardiomyopathy | 183 | AGT | angiotensin II | CTD_human | 22,497,828 | Alcohol-induced nitrative stress and apoptosis, which are mediated by angiotensin II interaction with AT1 and subsequent activation of a PKC-?1-dependent NOX pathway, are a causal factor in the development of alcoholic cardiomyopathy. | 0.2 | Alcohol-induced nitrative stress and apoptosis, which are mediated by <span class="gene" id="22497828-13-70-84">angiotensin II</span> interaction with AT1 and subsequent activation of a PKC-β1-dependent NOX pathway, are a causal factor in the development of <span class="disease" id="22497828-13-209-233">alcoholic cardiomyopathy</span>. | CTD_human |
null | null | Negative | MESH:D011654 | null | null | pulmonary edema | 303413 | null | myeloperoxidase | null | 28,189,055 | Afterwards, the influence of dopamine on histological changes, pulmonary edema, the lung wet/dry (W/D) ratio, myeloperoxidase (MPO) activity, polymorphonuclear(PMN)counts, inflammatory cytokine levels, and NLRP3 inflammasome protein expression were examined. | null | null | null |
null | null | Negative | MESH:D030342 | null | null | molecular dynamics | 8654 | null | PDE5 | null | 28,150,511 | Moreover, molecular dynamics (MD) simulations of selected hits complexed with PDE5 and off-targets were performed in order to get insights for structural and dynamical behaviors of the selected molecules as selective PDE5 inhibitors. | null | null | null |
1 | 0 | Biomarker | C0038220 | Status Epilepticus | disease | SE | 2185 | PTK2B | Pyk2 | CTD_human | 16,600,505 | The onset of SE was accompanied by activation of Src-family tyrosine kinases and Pyk2 in the post-synaptic density, consistent with a role for these enzymes in SE-induced tyrosine phosphorylation. | 0.2 | The onset of <span class="disease" id="16600505-6-13-15">SE</span> was accompanied by activation of Src-family tyrosine kinases and <span class="gene" id="16600505-6-81-85">Pyk2</span> in the post-synaptic density, consistent with a role for these enzymes in <span class="disease" id="16600505-6-160-162">SE</span>-induced tyrosine phosphorylation. | CTD_human |
2 | 0 | Biomarker | C0027627 | Neoplasm Metastasis | phenotype | metastatic cancer | 4638 | MYLK | MLCK | CTD_human | 12,970,723 | Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain. | 0.200549 | Dependence of <span class="disease" id="12970723-0-14-31">metastatic cancer</span> cell invasion on <span class="gene" id="12970723-0-49-53">MLCK</span>-catalyzed phosphorylation of myosin regulatory light chain. | CTD_human |
null | null | Negative | MESH:D005729 | null | null | pituitary gangliocytoma | 4221 | null | MEN1 | null | 28,079,577 | Herein we present a unique case of a pituitary gangliocytoma associated with a prolactinoma and a corticotroph adenoma in a patient affected by MEN1. | null | null | null |
1 | 0 | Biomarker | C0026010 | Microphthalmos | disease | microphthalmia | 5309 | PITX3 | PITX3 | CTD_human | 16,565,358 | Also studied were two siblings who were homozygous for the PITX3 mutation who had microphthalmia and significant neurologic impairment. | 0.401099 | Also studied were two siblings who were homozygous for the <span class="gene" id="16565358-3-59-64">PITX3</span> mutation who had <span class="disease" id="16565358-3-82-96">microphthalmia</span> and significant neurologic impairment. | CTD_human;HPO |
1 | 0 | Biomarker | C2931822 | Nasopharyngeal carcinoma | disease | NPC | 4313 | MMP2 | matrix metalloproteinase 2 | CTD_human | 20,461,718 | The results showed that serum levels of all the four proteins were indeed higher in NPC patients versus healthy controls and that the use of a three-marker panel (cystatin A, manganese superoxide dismutase and matrix metalloproteinase 2) can contribute to a better NPC detection than each marker alone. | 0.204396 | The results showed that serum levels of all the four proteins were indeed higher in <span class="disease" id="20461718-4-84-87">NPC</span> patients versus healthy controls and that the use of a three-marker panel (cystatin A, manganese superoxide dismutase and <span class="gene" id="20461718-4-210-236">matrix metalloproteinase 2</span>) can contribute to a better <span class="disease" id="20461718-4-265-268">NPC</span> detection than each marker alone. | CTD_human |
null | null | Negative | MESH:C567932 | null | null | OS | 28907 | null | B-2 | null | 28,023,383 | Patients which over-expressed both EGFR and C-erb B-2 fared worse in terms of OS (p=0.001)and DFS(p=0.002) due to additive effect of the prognostic power. | null | null | null |
3 | 12 | Biomarker | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | disease | type 2 diabetes | 54901 | CDKAL1 | CDKAL1 | CTD_human | 17,460,697 | A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. | 0.382528 | A variant in <span class="gene" id="17460697-0-13-19">CDKAL1</span> influences insulin response and risk of <span class="disease" id="17460697-0-60-75">type 2 diabetes</span>. | CTD_human |
1 | 0 | Biomarker | C0023467 | Leukemia, Myelocytic, Acute | disease | AML | 10125 | RASGRP1 | Rasgrp1 | CTD_human | 21,441,929 | We identified such mutations using a Sleeping Beauty transposon, which caused rapid-onset AML in 80% of mice with Npm1c, associated with mutually exclusive integrations in Csf2, Flt3 or Rasgrp1 in 55 of 70 leukemias. | 0.200824 | We identified such mutations using a Sleeping Beauty transposon, which caused rapid-onset <span class="disease" id="21441929-5-90-93">AML</span> in 80% of mice with Npm1c, associated with mutually exclusive integrations in Csf2, Flt3 or <span class="gene" id="21441929-5-186-193">Rasgrp1</span> in 55 of 70 leukemias. | CTD_human |
1 | 0 | Biomarker | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | disease | T-cell acute lymphoblastic leukemia | 4849 | CNOT3 | CNOT3 | CTD_human | 23,263,491 | Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. | 0.200275 | Exome sequencing identifies mutation in <span class="gene" id="23263491-0-40-45">CNOT3</span> and ribosomal genes RPL5 and RPL10 in <span class="disease" id="23263491-0-84-119">T-cell acute lymphoblastic leukemia</span>. | CTD_human |
3 | 0 | Therapeutic | C0036572 | Seizures | phenotype | seizures | 6750 | SST | somatostatin | CTD_human | 16,771,832 | Involvement of the somatostatin-2 receptor in the anti-convulsant effect of angiotensin IV against pilocarpine-induced limbic seizures in rats. | 0.200549 | Involvement of the <span class="gene" id="16771832-0-19-31">somatostatin</span>-2 receptor in the anti-convulsant effect of angiotensin IV against pilocarpine-induced limbic <span class="disease" id="16771832-0-126-134">seizures</span> in rats. | CTD_human |
7 | 0 | Therapeutic | C0242422 | Parkinsonian Disorders | group | parkinsonism | 5071 | PARK2 | PARK2 | CTD_human | 12,764,051 | Mutations in the parkin gene, PARK2, are a common cause of parkinsonism in familial as well as isolated cases with an age of onset <40 years and should be considered in the diagnostic work up of young-onset parkinsonism. | 0.4517 | Mutations in the <span class="gene" id="12764051-1-17-23">parkin</span> gene, <span class="gene" id="12764051-1-30-35">PARK2</span>, are a common cause of <span class="disease" id="12764051-1-59-71">parkinsonism</span> in familial as well as isolated cases with an age of onset <40 years and should be considered in the diagnostic work up of young-onset <span class="disease" id="12764051-1-207-219">parkinsonism</span>. | CTD_human;HPO |
1 | 0 | Biomarker | C0004352 | Autistic Disorder | disease | autism | 7432 | VIP | VIP | CTD_human | 17,521,630 | The current study examined the blockage of VIP during embryogenesis as a model for the behavioral deficits of autism. | 0.200275 | The current study examined the blockage of <span class="gene" id="17521630-5-43-46">VIP</span> during embryogenesis as a model for the behavioral deficits of <span class="disease" id="17521630-5-110-116">autism</span>. | CTD_human |
null | null | Negative | MESH:D030361 | null | null | HPV infections | 5506 | null | RG1 | null | 28,056,100 | In conclusion, RG1-based VLP are promising next generation vaccine candidates to target cutaneous HPV infections. | null | null | null |
9 | 52 | Biomarker | C0238052 | Xanthomatosis, Cerebrotendinous | disease | cerebrotendinous xanthomatosis | 1593 | CYP27A1 | sterol 27-hydroxylase | CTD_human | 17,444,890 | Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. | 0.638911 | Unique patient with <span class="disease" id="17444890-0-20-50">cerebrotendinous xanthomatosis</span>. Evidence for presence of a defect in a gene that is not identical to <span class="gene" id="17444890-0-121-142">sterol 27-hydroxylase</span>. | CTD_human;ORPHANET;UNIPROT |
12 | 0 | Therapeutic | C0027947 | Neutropenia | disease | neutropenia | 1440 | CSF3 | granulocyte colony-stimulating factor | CTD_human | 16,761,898 | Sulfur mustard-induced neutropenia: treatment with granulocyte colony-stimulating factor. | 0.21537 | Sulfur mustard-induced <span class="disease" id="16761898-0-23-34">neutropenia</span>: treatment with <span class="gene" id="16761898-0-51-88">granulocyte colony-stimulating factor</span>. | CTD_human |
null | null | Negative | MESH:D001859 | null | null | CIBP | 171209 | null | ASIC3 | null | 28,103,434 | Expression of TRPV1, TRPV4, ASIC1, ASIC2, and ASIC3 in the CIBP with quetiapine treatment group was significantly lower than that in the CIBP group. | null | null | null |
1 | 0 | Biomarker | C0020538 | Hypertensive disease | group | hypertension | 111 | ADCY5 | AC V | CTD_human | 12,717,102 | To assess the contributions of hypertension, left ventricular hypertrophy (LVH), the renin-angiotensin-aldosterone system (RAS), and the sympathetic nervous system to these changes, ventricular expression of AC V mRNA was measured at different ages in spontaneously hypertensive rats (SHRs). | 0.2 | To assess the contributions of <span class="disease" id="12717102-4-31-43">hypertension</span>, left ventricular hypertrophy (LVH), the renin-angiotensin-aldosterone system (RAS), and the sympathetic nervous system to these changes, ventricular expression of <span class="gene" id="12717102-4-208-212">AC V</span> mRNA was measured at different ages in spontaneously hypertensive rats (SHRs). | CTD_human |
null | null | Negative | MESH:D030342 | null | null | autosomal recessively inherited leukodystrophy | 118454 | null | Cx47 | null | 28,100,454 | Pelizaeus-Merzbacher-like disease or hypomyelinating leukodystrophy-2 is an autosomal recessively inherited leukodystrophy with childhood onset resulting from mutations in the gene encoding the gap junction protein connexin 47 (Cx47, encoded by GJC2). | null | null | null |
1 | 0 | Biomarker | C0271650 | Impaired glucose tolerance | phenotype | glucose intolerance | 948 | CD36 | Cd36 | CTD_human | 14,640,889 | Transgenic expression of Cd36 in the new lines was associated with significantly decreased serum fatty acids, amelioration of insulin resistance and glucose intolerance but failed to induce any consistent changes in blood pressure as measured by radiotelemetry. | 0.203557 | Transgenic expression of <span class="gene" id="14640889-5-25-29">Cd36</span> in the new lines was associated with significantly decreased serum fatty acids, amelioration of insulin resistance and <span class="disease" id="14640889-5-149-168">glucose intolerance</span> but failed to induce any consistent changes in blood pressure as measured by radiotelemetry. | CTD_human |
null | null | Negative | MESH:D009360 | null | null | AMOC | 717 | null | CO2 | null | 28,070,560 | By correcting the model biases, we show that the AMOC collapses 300 years after the atmospheric CO2 concentration is abruptly doubled from the 1990 level. | null | null | null |
2 | 23 | Biomarker | C0028326 | Noonan Syndrome | disease | Noonan syndrome | 6654 | SOS1 | SOS1 | CTD_human | 17,603,483 | Increased RAS signaling owing to PTPN11, SOS1 and KRAS mutations causes approximately 60% of Noonan syndrome cases, and PTPN11 mutations cause 90% of LEOPARD syndrome cases. | 0.433616 | Increased RAS signaling owing to PTPN11, <span class="gene" id="17603483-2-41-45">SOS1</span> and KRAS mutations causes approximately 60% of <span class="disease" id="17603483-2-93-108">Noonan syndrome</span> cases, and PTPN11 mutations cause 90% of LEOPARD syndrome cases. | CTD_human;ORPHANET |
null | null | Negative | MESH:D002277 | null | null | mammary carcinoma | 17975 | null | nucleolin | null | 28,028,501 | In this study, AS1411 aptamer was conjugated to Fe3O4@Au nanoparticles for specific targeting of mouse mammary carcinoma (4T1) cells that overexpress nucleolin. | null | null | null |
null | null | Negative | MESH:D015493 | null | null | Tropical Spastic Paraparesis | 7057 | null | HAM/TSP | null | 28,040,482 | HTLV-1 is the causal agent of Adult T cell Leukemia/lymphoma (ATLL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). | null | null | null |
null | null | Negative | MESH:D016778 | null | null | falciparum | 84717 | null | hrp2 | null | 28,177,502 | Deletions of the Plasmodium falciparum hrp2 (pfhrp2) gene cause false-negative RDT results and have never been investigated on a national level. | null | null | null |
null | null | Negative | MESH:D009369 | null | null | tumor | 2768677 | null | p53 | null | 28,049,824 | The function of tumor suppressor p53 has been under intense investigation. | null | null | null |
null | null | Negative | MESH:D062788 | null | null | adenomyosis | 2796 | null | gonadotropin-releasing hormone | null | 28,057,126 | Objective: To investigate the value of using gonadotropin-releasing hormone agonist (GnRH-a) pretreatment in adenomyosis patients before adenomyomectomy. | null | null | null |
null | null | Negative | MESH:D018487 | null | null | decreases left ventricular fibrosis | 26395;26396 | null | MEK1/2 | null | 28,011,205 | In these mice, this novel MEK1/2 inhibitor is well tolerated, improves left ventricular systolic function, decreases left ventricular fibrosis, has beneficial effects on skeletal muscle structure and pathology and prolongs survival. | null | null | null |
null | null | Negative | MESH:D000377 | null | null | time-of-flight | 55079 | null | TOF | null | 28,062,597 | The purpose of this study was to evaluate the effect of susceptibility artifacts related to metallic implants on adjacent metabolically active lesions in clinical simultaneous PET/MR scanning for both time-of-flight (TOF) and non-TOF reconstructed PET images. | null | null | null |
null | null | Negative | MESH:C566250 | null | null | AIP | 6822 | null | DHEAS | null | 28,095,038 | ABBREVIATIONS: ACA = adrenocortical adenoma ACC = adrenocortical carcinoma AIP = aryl hydrocarbon receptor-interacting protein DHEAS = dehydroepiandrosterone sulfate; GH growth hormone PASAT = pure androgen-secreting adrenal tumor. | null | null | null |
1 | 0 | Therapeutic | C0020437 | Hypercalcemia | disease | hypercalcemia | 799 | CALCR | Calcitonin receptor | CTD_human | 18,627,265 | Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice. | 0.200275 | <span class="gene" id="18627265-0-0-19">Calcitonin receptor</span> plays a physiological role to protect against <span class="disease" id="18627265-0-66-79">hypercalcemia</span> in mice. | CTD_human |
35 | 84 | Biomarker | C0022716 | Menkes Kinky Hair Syndrome | disease | Menkes disease | 538 | ATP7A | Atp7a | CTD_human | 22,815,746 | Prenatal treatment of mosaic mice (Atp7a mo-ms) mouse model for Menkes disease, with copper combined by dimethyldithiocarbamate (DMDTC). | 0.727934 | Prenatal treatment of mosaic mice (<span class="gene" id="22815746-0-35-40">Atp7a</span> mo-ms) mouse model for <span class="disease" id="22815746-0-64-78">Menkes disease</span>, with copper combined by dimethyldithiocarbamate (DMDTC). | CTD_human;ORPHANET;UNIPROT |
1 | 0 | Biomarker | C0025500 | Mesothelioma | disease | mesotheliomas | 2662 | GDF10 | BMP3b | CTD_human | 18,949,431 | The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas. | 0.203008 | The aberrant promoter methylation of <span class="gene" id="18949431-0-37-42">BMP3b</span> and BMP6 in malignant pleural <span class="disease" id="18949431-0-73-86">mesotheliomas</span>. | CTD_human |
null | null | Negative | MESH:C538248 | null | null | cerebral amyloidosis | 11820 | null | APP | null | 28,070,672 | Consistent with the human data, subsequent analyses using the APPswe/PS1 E9 (APP/PS1) mouse model of cerebral amyloidosis show that PGRN deficiency has no exacerbating effects on Ab pathology. | null | null | null |
2 | 0 | Biomarker | C0010308 | Congenital Hypothyroidism | disease | CH | 50506 | DUOX2 | DUOX2 | CTD_human | 16,134,168 | Only one study reported mutations in DUOX2 gene in congenital hypothyroidism (CH) associated with total iodide organification defect (TIOD) in homozygosity or with partial iodide organification defect (PIOD) in heterozygous patients. | 0.414532 | Only one study reported mutations in <span class="gene" id="16134168-2-37-42">DUOX2</span> gene in <span class="disease" id="16134168-2-51-76">congenital hypothyroidism</span> (<span class="disease" id="16134168-2-78-80">CH</span>) associated with total iodide organification defect (TIOD) in homozygosity or with partial iodide organification defect (PIOD) in heterozygous patients. | CTD_human;HPO |
1 | 0 | Biomarker | C0001824 | Agranulocytosis | disease | agranulocytosis | 4835 | NQO2 | NQO2 | CTD_human | 14,617,031 | NQO2 gene is associated with clozapine-induced agranulocytosis. | 0.202682 | <span class="gene" id="14617031-0-0-4">NQO2</span> gene is associated with clozapine-induced <span class="disease" id="14617031-0-47-62">agranulocytosis</span>. | CTD_human |
1 | 0 | Biomarker | C0021390 | Inflammatory Bowel Diseases | group | IBD | 1670 | DEFA5 | DEFA5 | CTD_human | 18,394,979 | The SNPs genotyped in our study were surrogates for common variants, and observed associations between these and IBD status are likely due to linkage disequilibrium with a functional common DEFA5 variant. | 0.205415 | The SNPs genotyped in our study were surrogates for common variants, and observed associations between these and <span class="disease" id="18394979-12-113-116">IBD</span> status are likely due to linkage disequilibrium with a functional common <span class="gene" id="18394979-12-190-195">DEFA5</span> variant. | CTD_human |
1 | 0 | Biomarker | C0017662 | Glomerulonephritis, Membranoproliferative | disease | membranoproliferative glomerulonephritis | 3075 | CFH | factor h | CTD_human | 14,978,182 | Heterozygous and homozygous factor h deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases. | 0.212059 | Heterozygous and homozygous <span class="gene" id="14978182-0-28-36">factor h</span> deficiencies associated with hemolytic uremic syndrome or <span class="disease" id="14978182-0-95-135">membranoproliferative glomerulonephritis</span>: report and genetic analysis of 16 cases. | CTD_human |
1 | 0 | Biomarker | C0152013 | Adenocarcinoma of lung (disorder) | disease | lung adenocarcinoma | 6794 | STK11 | lkb1 | CTD_human | 24,793,789 | The MZF1/c-MYC axis mediates lung adenocarcinoma progression caused by wild-type lkb1 loss. | 0.204121 | The MZF1/c-MYC axis mediates <span class="disease" id="24793789-0-29-48">lung adenocarcinoma</span> progression caused by wild-type <span class="gene" id="24793789-0-81-85">lkb1</span> loss. | CTD_human |
null | null | Negative | MESH:D009336 | null | null | tumor necrosis factor a | 24451 | null | heme oxygenase 1 | null | 28,061,403 | It also significantly restored hippocampal level of reactive oxygen species (ROS), glutathione (GSH), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), activity of catalase and caspase 3, nuclear factor-<kappa>B (NF-kB), toll-like receptor 4 (TLR4), tumor necrosis factor a (TNFa), interleukin-1b (IL-1b), neural cell adhesion molecule (NCAM), glial fibrillary acidic protein (GFAP), cathepsin D, and heme oxygenase 1 (HO-1). | null | null | null |
null | null | Negative | MESH:C535607 | null | null | AGS | 7040 | null | TGF-b1 | null | 28,042,090 | In the present study, we used real-time PCR assay to demonstrate TGF-b1-induced miR-574-3p upregulation in AGS cells, which was inhibited by TGF-b receptor I inhibitor SB431542. | null | null | null |
null | null | Negative | MESH:D016773 | null | null | cutaneous leishmaniasis | 216799 | null | NLRP3 | null | 28,192,528 | Using murine models of inflammation induced by the protozoan parasite leishmania, and data obtained from patients with cutaneous leishmaniasis, we uncovered a previously unrecognized role for NLRP3 inflammasome activation and IL-1b release as a detrimental consequence of CD8+ T cell-mediated cytotoxicity, ultimately resulting in chronic inflammation. | null | null | null |
1 | 0 | Biomarker | C1142166 | Brugada Syndrome (disorder) | disease | Brugada syndrome | 23493 | HEY2 | HEY2 | CTD_human | 23,872,634 | Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. | 0.200824 | Common variants at SCN5A-SCN10A and <span class="gene" id="23872634-0-36-40">HEY2</span> are associated with <span class="disease" id="23872634-0-61-77">Brugada syndrome</span>, a rare disease with high risk of sudden cardiac death. | CTD_human |
null | null | Negative | MESH:D004715 | null | null | endometriosis | 16193 | null | Il-6 | null | 28,138,997 | RESULTS: Lipopolysaccharide increased total number, size, and mRNA expression of Ptgs-2, Vegf, Ccl-2, and Il-6 in endometriosis-like lesions. | null | null | null |
null | null | Negative | MESH:D014777 | null | null | viral infection | 85480 | null | TSLP | null | 28,127,565 | CRSwNP epithelial cells release TSLP and IL-25 when stimulated by poly(I:C) but not by DP or AF, suggesting that viral infection may contribute to maintain and amplify the T2 immune response seen in CRSwNP. | null | null | null |
null | null | Negative | MESH:D001249 | null | null | asthma | 296320 | null | rNAP | null | 28,087,613 | Here, we sought to determine whether systemic or mucosal pre-administration of recombinant H. pylori NAP (rNAP) could prevent ovalbumin (OVA)-induced allergic asthma in mice. | null | null | null |
null | null | Negative | MESH:D003920 | null | null | type 2 diabetes mellitus | 14526 | null | GLP-1 | null | 28,213,324 | Qing-Hua Granule (QHG), the modified formulation of a classical Chinese prescription named Gegen Qinlian Decoction, was clinically employed to treat type 2 diabetes mellitus (T2DM) through regulation of glucagon-like peptide-1 (GLP-1). | null | null | null |
1 | 0 | Biomarker | C0026837 | Muscle Rigidity | phenotype | rigid | 2643 | GCH1 | GTP cyclohydrolase 1 | CTD_human | 17,368,676 | We report on a GTP cyclohydrolase 1 mutation-confirmed heterozygous case presenting with an infantile hypokinetic rigid syndrome and delay in attainment of motor milestones starting from the first year of life. | 0.4 | We report on a <span class="gene" id="17368676-1-15-35">GTP cyclohydrolase 1</span> mutation-confirmed heterozygous case presenting with an infantile hypokinetic <span class="disease" id="17368676-1-114-119">rigid</span> syndrome and delay in attainment of motor milestones starting from the first year of life. | CTD_human;HPO |
null | null | Negative | MESH:D009369 | null | null | tumor | 403885 | null | MMP-9 | null | 28,215,146 | The docking of TIMP-3 protein with MMP-2 and MMP-9 to represent conformational structure of these two proteins which interact with each other but if mislead resulting the progression of tumor in canine. | null | null | null |
null | null | Negative | MESH:D012174 | null | null | adRP | 23020 | null | SNRNP200 | null | 28,076,437 | Finally, we expanded the molecular spectrum of PRPH2, PRPF8, RHO, RP1, SNRNP200, and TOPORS-associated adRP by the identification of 17 novel mutations. | null | null | null |
null | null | Negative | MESH:D007249 | null | null | inflammation | 18787 | null | PAI-1 | null | 28,205,266 | Our results could suggest that PNP downregulates VSMC proliferation and migration, mediated by PAI-1 and TSP-1, and reduces inflammation and oxidative stress in vessels. | null | null | null |
1 | 0 | Biomarker | C0022661 | Kidney Failure, Chronic | disease | CRF | 213 | ALB | serum albumin | CTD_human | 11,938,814 | Membranous nephropathy model was induced by cationized bovine serum albumin intravenous administration in rats for 7 weeks and developed to CRF. | 0.203571 | Membranous nephropathy model was induced by cationized bovine <span class="gene" id="11938814-2-62-75">serum albumin</span> intravenous administration in rats for 7 weeks and developed to <span class="disease" id="11938814-2-140-143">CRF</span>. | CTD_human |
6 | 0 | Biomarker | C0020429 | Hyperalgesia | phenotype | hyperalgesia | 3553 | IL1B | IL-1 | CTD_human | 20,937,348 | The present study suggests that an IL-1 receptor antagonist effectively attenuates or blocks long-lasting hyperalgesia and microglia activation produced by LPS exposure in the neonatal period of rats. | 0.280275 | The present study suggests that an <span class="gene" id="20937348-9-35-39">IL-1</span> receptor antagonist effectively attenuates or blocks long-lasting <span class="disease" id="20937348-9-106-118">hyperalgesia</span> and microglia activation produced by LPS exposure in the neonatal period of rats. | CTD_human |
null | null | Negative | MESH:D012512 | null | null | Ewing family tumors | 256646 | null | NUT | null | 28,176,137 | Sinonasal NUT-midline carcinoma, adamantinoma-like Ewing family tumors and most recently, SMARCB1(INI1)-deficient sinonasal carcinoma are the main entities defined by specific genetic aberrations. | null | null | null |
2 | 1 | Biomarker | C0025202 | melanoma | disease | melanoma | 51151 | SLC45A2 | SLC45A2 | CTD_human | 21,559,390 | A customized pigmentation SNP array identifies a novel SNP associated with melanoma predisposition in the SLC45A2 gene. | 0.218391 | A customized pigmentation SNP array identifies a novel SNP associated with <span class="disease" id="21559390-0-75-83">melanoma</span> predisposition in the <span class="gene" id="21559390-0-106-113">SLC45A2</span> gene. | CTD_human |
null | null | Negative | MESH:D003528 | null | null | adenoid cystic carcinoma | 56477 | null | MEC | null | 28,139,061 | CRTC1/MAML2 and MYB/NFIB were also analyzed in MEC and adenoid cystic carcinoma cases, respectively. | null | null | null |
4 | 0 | Biomarker | C0919267 | ovarian neoplasm | disease | ovarian tumors | 6597 | SMARCA4 | SMARCA4 | CTD_human | 24,658,001 | We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene SMARCA4 in 75% (9/12) of SCCOHT cases in addition to SMARCA4 protein loss in 82% (14/17) of SCCOHT tumors but in only 0.4% (2/485) of other primary ovarian tumors. | 0.200275 | We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene <span class="gene" id="24658001-2-99-106">SMARCA4</span> in 75% (9/12) of SCCOHT cases in addition to <span class="gene" id="24658001-2-152-159">SMARCA4</span> protein loss in 82% (14/17) of SCCOHT tumors but in only 0.4% (2/485) of other primary <span class="disease" id="24658001-2-247-261">ovarian tumors</span>. | CTD_human |
1 | 0 | Biomarker | C0162871 | Aortic Aneurysm, Abdominal | disease | abdominal aortic aneurysm | 5743 | PTGS2 | cyclooxygenase-2 | CTD_human | 16,514,081 | Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. | 0.200549 | Selective <span class="gene" id="16514081-0-10-26">cyclooxygenase-2</span> inhibition with celecoxib decreases angiotensin II-induced <span class="disease" id="16514081-0-86-111">abdominal aortic aneurysm</span> formation in mice. | CTD_human |
null | null | Negative | OMIM:217000 | null | null | C2 tumors | 11186 | null | RASSF1 | null | 28,142,444 | Moreover, we discriminated HB tumors in C1 and C2 subclasses by using the 16-gene signature and correlation of these subtypes with the methylation status of RASSF1 showed a significant association (p=0.0037) for aggressive C2 tumors (8/11), but not C1 tumors (1/10). | null | null | null |
2 | 0 | Biomarker | C0007131 | Non-Small Cell Lung Carcinoma | disease | NSCLC | 1029 | CDKN2A | cyclin-dependent kinase inhibitor 2A | CTD_human | 18,337,602 | In a multivariate model, promoter methylation of the cyclin-dependent kinase inhibitor 2A gene p16, the H-cadherin gene CDH13, the Ras association domain family 1 gene RASSF1A, and the adenomatous polyposis coli gene APC in tumors and in histologically tumor-negative lymph nodes was associated with tumor recurrence, independently of NSCLC stage, age, sex, race, smoking history, and histologic characteristics of the tumor. | 0.233726 | In a multivariate model, promoter methylation of the <span class="gene" id="18337602-5-53-89">cyclin-dependent kinase inhibitor 2A</span> gene p16, the H-cadherin gene CDH13, the Ras association domain family 1 gene RASSF1A, and the adenomatous polyposis coli gene APC in tumors and in histologically tumor-negative lymph nodes was associated with tumor recurrence, independently of <span class="disease" id="18337602-5-335-340">NSCLC</span> stage, age, sex, race, smoking history, and histologic characteristics of the tumor. | CTD_human |
6 | 0 | Biomarker | C0149721 | Left Ventricular Hypertrophy | disease | LV hypertrophy | 183 | AGT | angiotensin II | CTD_human | 24,688,123 | In contrast to TAC, antagonizing the function of CTGF had no effect on LV dysfunction or LV hypertrophy in mice subjected to 4-week angiotensin II infusion. | 0.254301 | In contrast to TAC, antagonizing the function of CTGF had no effect on LV dysfunction or <span class="disease" id="24688123-7-89-103">LV hypertrophy</span> in mice subjected to 4-week <span class="gene" id="24688123-7-132-146">angiotensin II</span> infusion. | CTD_human |
1 | 0 | Biomarker | C0026848 | Myopathy | group | myopathy | 84466 | MEGF10 | MEGF10 | CTD_human | 22,101,682 | Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD). | 0.201099 | Mutations in <span class="gene" id="22101682-0-13-19">MEGF10</span>, a regulator of satellite cell myogenesis, cause early onset <span class="disease" id="22101682-0-81-89">myopathy</span>, areflexia, respiratory distress and dysphagia (EMARDD). | CTD_human |
null | null | Negative | MESH:C562591 | null | null | XPD | 1643 | null | DDB2 | null | 28,115,302 | Thirty-eight polymorphisms in eight NER genes were genotyped by Sequenom MassARRAY platform, including XPA, XPC, DDB2, XPB (ERCC3), XPD (ERCC2), ERCC1, XPF (ERCC4), and XPG (ERCC5). | null | null | null |
null | null | Negative | MESH:D009369 | null | null | tumor | 397603 | null | IDH2 | null | 28,157,189 | All the RHOA and IDH2 mutations were confined to the PD1+ cells, indicating that some, including RHOA and IDH2 mutations, being specific events in tumor cells. | null | null | null |
null | null | Negative | MESH:D017827 | null | null | wild-type | 27643 | null | GDX | null | 28,131,743 | We identified altered gene expression in prepubertally gonadectomized (GDX) inha/Tag and wild-type (WT) mice. | null | null | null |
4 | 0 | Biomarker | C0345967 | Malignant mesothelioma | disease | MM | 8314 | BAP1 | BAP1 | CTD_human | 26,463,840 | BAP1 mutations occurred in asbestos-exposed MM. | 0.205495 | <span class="gene" id="26463840-13-0-4">BAP1</span> mutations occurred in asbestos-exposed <span class="disease" id="26463840-13-44-46">MM</span>. | CTD_human |
null | null | Negative | MESH:D001796 | null | null | protein aggregation | 616199 | null | aldose reductase | null | 28,192,136 | The effect of selected flavonoids was observed on glycation induced lens opacity, AGE fluorescence, carbonyl group formation (a biomarker of glycation), protein aggregation and aldose reductase (AR) inhibition. | null | null | null |
null | null | Negative | MESH:C566610 | null | null | axis | 83430 | null | IL-23 | null | 28,191,009 | In tumor tissue of p47phox-/- mice, the IL-23/IL-17 axis was crucially hampered. | null | null | null |
null | null | Negative | MESH:D001145 | null | null | ventricular arrhythmia | 100008935 | null | Cx43 | null | 28,158,934 | CONCLUSION: A single exposure of the dog heart to (12) C irradiation attenuated vulnerability to ventricular arrhythmia after the induction of MI for at least 1 year through the modulation of Cx43 expression. | null | null | null |
1 | 0 | Biomarker | C0002395 | Alzheimer's Disease | disease | AD | 3479 | IGF1 | IGF-I | CTD_human | 15,750,215 | The strikingly reduced CNS expression of genes encoding insulin, IGF-I, and IGF-II, as well as the insulin and IGF-I receptors, suggests that AD may represent a neuro-endocrine disorder that resembles, yet is distinct from diabetes mellitus. | 0.213642 | The strikingly reduced CNS expression of genes encoding insulin, <span class="gene" id="15750215-6-65-70">IGF-I</span>, and IGF-II, as well as the insulin and <span class="gene" id="15750215-6-111-116">IGF-I</span> receptors, suggests that <span class="disease" id="15750215-6-142-144">AD</span> may represent a neuro-endocrine disorder that resembles, yet is distinct from diabetes mellitus. | CTD_human |
1 | 0 | Biomarker | C0010674 | Cystic Fibrosis | disease | cystic fibrosis | 7132 | TNFRSF1A | TNFRSF1A | CTD_human | 16,463,024 | The TNFalpha receptor TNFRSF1A and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in cystic fibrosis. | 0.205415 | The TNFalpha receptor <span class="gene" id="16463024-0-22-30">TNFRSF1A</span> and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in <span class="disease" id="16463024-0-111-126">cystic fibrosis</span>. | CTD_human |
null | null | Negative | MESH:D013901 | null | null | neurovascular injury | 111345 | null | SAA | null | 28,190,474 | HYPOTHESIS: The aim of present study was to investigate the relationship between the effectiveness of SAA against neurovascular injury and its effects on calpain activation and endothelial nitric oxide synthase (eNOS) uncoupling. | null | null | null |
null | null | Negative | MESH:D009336 | null | null | necrosis | 56532 | null | RIP3 | null | 28,127,258 | Moreover, the up-regulation of RIP3 (a necroptosis marker) by 5-FU, and the activation of RIP3 by TNF-a, synergistically triggered necroptosis (programmed necrosis). | null | null | null |
null | null | Negative | MESH:D009765 | null | null | obesity | 18596 | null | Pdgfrb | null | 28,122,789 | Consequently, diet-induced obesity and the associated deterioration of glucose metabolism in wild-type mice were absent in Pdgfrb-knockout mice. | null | null | null |
1 | 2 | Biomarker | C0003873 | Rheumatoid Arthritis | disease | rheumatoid arthritis | 122618 | PLD4 | PLD4 | CTD_human | 22,446,963 | Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10(-8), including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2. | 0.2 | Our study identified nine loci newly associated with <span class="disease" id="22446963-3-53-73">rheumatoid arthritis</span> at a threshold of P < 5.0 × 10(-8), including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, <span class="gene" id="22446963-3-176-180">PLD4</span> and PTPN2. | CTD_human |
null | null | Negative | MESH:D008067 | null | null | lipomas | 574411 | null | miR-451 | null | 28,036,291 | Here, we evaluated miR-155, miR-21, miR-143, miR-145 and miR-451 that are implicated in LPS, as novel FFPE tissue biomarkers.A total of 83 FFPE tissue specimens from primary LPS and lipomas (LPM) were analyzed. | null | null | null |
1 | 0 | Therapeutic | C0018801 | Heart failure | disease | HF | 3315 | HSPB1 | Hsp27 | CTD_human | 17,481,944 | Transgenic mice (TG) with cardiac specific over-expression of Hsp27 and their wild type littermates (WT) were challenged with doxorubicin (25 mg/kg, IP) to induce HF. | 0.2 | Transgenic mice (TG) with cardiac specific over-expression of <span class="gene" id="17481944-4-62-67">Hsp27</span> and their wild type littermates (WT) were challenged with doxorubicin (25 mg/kg, IP) to induce <span class="disease" id="17481944-4-163-165">HF</span>. | CTD_human |
8 | 2 | Biomarker | C0005586 | Bipolar Disorder | disease | bipolar disorder | 775 | CACNA1C | CACNA1C | CTD_human | 18,711,365 | Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. | 0.425013 | Collaborative genome-wide association analysis supports a role for ANK3 and <span class="gene" id="18711365-0-76-83">CACNA1C</span> in <span class="disease" id="18711365-0-87-103">bipolar disorder</span>. | CTD_human;PSYGENET |
1 | 0 | Biomarker | C0032927 | Precancerous Conditions | phenotype | premalignant | 1029 | CDKN2A | p16 | CTD_human | 24,991,542 | Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma. | 0.214155 | Promoter region hypermethylation and mRNA expression of MGMT and <span class="gene" id="24991542-0-65-68">p16</span> genes in tissue and blood samples of human <span class="disease" id="24991542-0-112-124">premalignant</span> oral lesions and oral squamous cell carcinoma. | CTD_human |
null | null | Negative | MESH:D010003 | null | null | osteoarthritis | 20343 | null | L-selectin | null | 28,087,905 | UNASSIGNED: Objective: To observe the influence of matrix metalloproteinases-2 (MMP-2), monocyte chemoattractant protein-1 (MCP-1), CD47, L-selectin and advanced oxidation proteinproducts (AOPP) in osteoarthritis and the intervention of curcumin. | null | null | null |
1 | 1 | Biomarker | C0002395 | Alzheimer's Disease | disease | Alzheimer's disease | 5649 | RELN | Reelin | CTD_human | 20,610,758 | Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice. | 0.209536 | Reduced <span class="gene" id="20610758-0-8-14">Reelin</span> expression accelerates amyloid-beta plaque formation and tau pathology in transgenic <span class="disease" id="20610758-0-100-119">Alzheimer's disease</span> mice. | CTD_human |
null | null | Negative | MESH:C567932 | null | null | OS | 672 | null | BRCA1 | null | 28,021,523 | AIM: To investigate the prognostic significance of BRCA1 PM with respect to RFS and OS in patients receiving chemotherapy for stage I-III TNBC. | null | null | null |
null | null | Negative | MESH:D001523 | null | null | reduced arbor complexity | 174305 | null | IRE-1 | null | 28,114,319 | PVD neurons of nematodes lacking ire-1 display reduced arbor complexity, whereas mutations in genes encoding other ER stress sensors displayed normal PVD dendrites, specifying IRE-1 as a selective ER stress sensor that is essential for PVD dendrite morphogenesis. | null | null | null |
1 | 0 | Biomarker | C1956346 | Coronary Artery Disease | disease | coronary artery disease | 959 | CD40LG | CD40 ligand | CTD_human | 16,368,305 | Effect of atorvastatin on circulating proinflammatory T-lymphocyte subsets and soluble CD40 ligand in patients with stable coronary artery disease--a randomized, placebo-controlled study. | 0.286015 | Effect of atorvastatin on circulating proinflammatory T-lymphocyte subsets and soluble <span class="gene" id="16368305-0-87-98">CD40 ligand</span> in patients with stable <span class="disease" id="16368305-0-123-146">coronary artery disease</span>--a randomized, placebo-controlled study. | CTD_human |
96 | 174 | Biomarker | C0019202 | Hepatolenticular Degeneration | disease | WD | 540 | ATP7B | Atp7b | CTD_human | 21,364,284 | The present study focuses on the structural mitochondrial alterations that precede clinical symptoms in the livers of rats lacking Atp7b, an animal model for WD. | 0.885769 | The present study focuses on the structural mitochondrial alterations that precede clinical symptoms in the livers of rats lacking <span class="gene" id="21364284-2-131-136">Atp7b</span>, an animal model for <span class="disease" id="21364284-2-158-160">WD</span>. | CTD_human;ORPHANET;UNIPROT |
null | null | Negative | MESH:D007249 | null | null | inflammation | 19164 | null | PS1 | null | 28,189,498 | Then, we demonstrated the enhanced recruitment of inflammation-resolving monocytes across the choroid plexus and perivascular spaces to cerebral sites of plaque pathology in APP/PS1 mice immunized with BCG. | null | null | null |
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