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null | null | Negative | MESH:D007674 | null | null | IgA nephropathy | 60498 | null | IgAN | null | 28,203,107 | AIMS: The aims of this study were to validate the diagnosis of IgA nephropathy (IgAN) in Swedish biopsy registers against patient charts and to describe the clinical characteristics of patients with a biopsy indicating IgAN. | null | null | null |
7 | 23 | Biomarker | C1848533 | Ataxia with vitamin E deficiency | disease | ataxia with isolated vitamin E deficiency | 7274 | TTPA | alpha-TTP | CTD_human | 18,458,655 | A novel delins mutation in the alpha-TTP gene in a family segregating ataxia with isolated vitamin E deficiency. | 0.686044 | A novel delins mutation in the <span class="gene" id="18458655-0-31-40">alpha-TTP</span> gene in a family segregating <span class="disease" id="18458655-0-70-111">ataxia with isolated vitamin E deficiency</span>. | CTD_human;ORPHANET;UNIPROT |
28 | 0 | Biomarker | C0007131 | Non-Small Cell Lung Carcinoma | disease | nsclc | 238 | ALK | ALK | CTD_human | 22,787,409 | However, the benefits of these agents are not uniform across the spectrum of nsclc, and optimizing their utility requires some degree of subgrouping of nsclc by the presence or absence of certain biomarkers.The biomarkers of current or imminent value are EGFR and KRAS mutational status, ALK rearrangements, and MET immunohistochemistry. | 0.28 | However, the benefits of these agents are not uniform across the spectrum of <span class="disease" id="22787409-3-77-82">nsclc</span>, and optimizing their utility requires some degree of subgrouping of <span class="disease" id="22787409-3-152-157">nsclc</span> by the presence or absence of certain biomarkers.The biomarkers of current or imminent value are EGFR and KRAS mutational status, <span class="gene" id="22787409-3-288-291">ALK</span> rearrangements, and MET immunohistochemistry. | CTD_human |
1 | 0 | Biomarker | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | disease | lymphoblastic lymphoma | 63978 | PRDM14 | Prdm14 | CTD_human | 19,043,588 | This study implicates Prdm14 as a proto-oncogene involved in lymphoblastic lymphoma formation. | 0.2 | This study implicates <span class="gene" id="19043588-9-22-28">Prdm14</span> as a proto-oncogene involved in <span class="disease" id="19043588-9-61-83">lymphoblastic lymphoma</span> formation. | CTD_human |
1 | 0 | Biomarker | C0030567 | Parkinson Disease | disease | Parkinson disease | 5243 | ABCB1 | ABCB1 | CTD_human | 20,558,393 | Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease. | 0.234532 | Interaction between <span class="gene" id="20558393-0-20-25">ABCB1</span> and professional exposure to organochlorine insecticides in <span class="disease" id="20558393-0-86-103">Parkinson disease</span>. | CTD_human |
1 | 0 | Biomarker | C0007131 | Non-Small Cell Lung Carcinoma | disease | NSCLC | 4504 | MT3 | metallothionein 3 | CTD_human | 17,043,644 | Of the more than 200 genes upregulated by these treatments, three of these, neuronatin, metallothionein 3 and cystatin E/M, were frequently hypermethylated and transcriptionally downregulated in NSCLC cell lines and tumors. | 0.200275 | Of the more than 200 genes upregulated by these treatments, three of these, neuronatin, <span class="gene" id="17043644-5-88-105">metallothionein 3</span> and cystatin E/M, were frequently hypermethylated and transcriptionally downregulated in <span class="disease" id="17043644-5-195-200">NSCLC</span> cell lines and tumors. | CTD_human |
null | null | Negative | MESH:D009369 | null | null | cancer | 5595;5594 | null | ERK1/2 | null | 28,022,187 | UNASSIGNED: 3006^ Background: The Ras-Raf-MEK-extra-cellular signal-regulated kinase 1 and 2 (ERK1/2) pathway is frequently deregulated in human cancer. | null | null | null |
1 | 0 | Biomarker | C0004153 | Atherosclerosis | disease | atherosclerosis | 7422 | VEGFA | VEGF | CTD_human | 15,937,083 | VEGF polymorphisms and severity of atherosclerosis. | 0.227377 | <span class="gene" id="15937083-0-0-4">VEGF</span> polymorphisms and severity of <span class="disease" id="15937083-0-35-50">atherosclerosis</span>. | CTD_human |
2 | 0 | Therapeutic | C0028754 | Obesity | disease | obesity | 9370 | ADIPOQ | Acrp30 | CTD_human | 14,617,771 | The long-term expression of recombinant adeno-associated virus-Acrp30 vectors was tested after intramuscular or intraportal injection in female Sprague-Dawley rats with diet-induced obesity. | 0.389121 | The long-term expression of recombinant adeno-associated virus-<span class="gene" id="14617771-5-63-69">Acrp30</span> vectors was tested after intramuscular or intraportal injection in female Sprague-Dawley rats with diet-induced <span class="disease" id="14617771-5-182-189">obesity</span>. | CTD_human |
17 | 19 | Biomarker | C0162568 | Erythropoietic Protoporphyria | disease | EPP | 2235 | FECH | Ferrochelatase | CTD_human | 17,600,043 | Ferrochelatase-deficient (fch/fch) mice are an animal model for human EPP. | 0.730919 | <span class="gene" id="17600043-2-0-14">Ferrochelatase</span>-deficient (fch/fch) mice are an animal model for human <span class="disease" id="17600043-2-70-73">EPP</span>. | CTD_human;ORPHANET;UNIPROT |
1 | 0 | Biomarker | C0596263 | Carcinogenesis | phenotype | tumorigenesis | 1029 | CDKN2A | Cdkn2a | CTD_human | 21,526,190 | Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. | 0.28 | Losses of both products of the <span class="gene" id="21526190-0-31-37">Cdkn2a</span>/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate <span class="disease" id="21526190-0-132-145">tumorigenesis</span>. | CTD_human |
null | null | Negative | MESH:C564145 | null | null | HBD-2 | 3576 | null | IL-8 | null | 28,147,379 | Concentrations of pro- and anti-inflammatory mediators (interleukin [IL]-1b, IL-6, tumor necrosis factor [TNF]-a, IL-10, and TGF-b), chemokines (IL-8 and GCP-2), and human b-defensins (HBD-1, HBD-2, and HBD-3) were measured in the culture supernatants. | null | null | null |
null | null | Negative | MESH:D008228 | null | null | NHL | 1019;1021 | null | CDK 4/6 | null | 28,023,509 | CONCLUSIONS: PD 0332991 represents a promising and specific inhibitor for therapeutic targeting of CDK 4/6 in DLBCL, and possibly other B-cell NHL. | null | null | null |
null | null | Negative | MESH:D015862 | null | null | choroidal thickness | 64396 | null | GCL | null | 28,028,626 | Patients and HC were examined with OCT. RNFL, ganglion cell layer (GCL), foveal thickness (FT), choroidal thickness (CT) and total macular volume (TMV) were calculated for right eyes (RE) and left eyes (LE). | null | null | null |
2 | 0 | Biomarker | C0020429 | Hyperalgesia | phenotype | hyperalgesia | 6869 | TACR1 | NK-1 receptor | CTD_human | 17,123,731 | Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. | 0.2 | Spinal <span class="gene" id="17123731-0-7-20">NK-1 receptor</span> expressing neurons mediate opioid-induced <span class="disease" id="17123731-0-63-75">hyperalgesia</span> and antinociceptive tolerance via activation of descending pathways. | CTD_human |
null | null | Negative | MESH:D017827 | null | null | WT | 685 | null | Btc | null | 28,139,851 | We show that Btc mRNA is strongly upregulated in immature and dedifferentiated Sox2<sup>+</sup>Schwann cells located in the sciatic nerve distal stump of WT mice, but not Wld<sup>S</sup>mutants. | null | null | null |
null | null | Negative | MESH:D009202 | null | null | cardiomyopathy | 16905 | null | lamin A/C | null | 28,011,205 | Mice with dilated cardiomyopathy caused by a lamin A/C gene mutation have abnormally increased cardiac ERK1/2 activity. | null | null | null |
3 | 0 | Biomarker | C0220633 | Uveal melanoma | disease | uveal melanoma | 8314 | BAP1 | BAP1 | CTD_human | 21,874,000 | These results identify a BAP1-related cancer syndrome that is characterized by mesothelioma and uveal melanoma. | 0.408791 | These results identify a <span class="gene" id="21874000-6-25-29">BAP1</span>-related cancer syndrome that is characterized by mesothelioma and <span class="disease" id="21874000-6-96-110">uveal melanoma</span>. | CTD_human;HPO |
1 | 0 | Biomarker | C0033626 | Protein Deficiency | disease | Protein deficiency | 2936 | GSR | glutathione reductase | CTD_human | 15,865,262 | Protein deficiency in normal rats resulted in a significant increase in hepatic activities of catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase and the levels of lipid peroxidation. | 0.2 | <span class="disease" id="15865262-5-0-18">Protein deficiency</span> in normal rats resulted in a significant increase in hepatic activities of catalase, glutathione peroxidase, <span class="gene" id="15865262-5-128-149">glutathione reductase</span>, and glutathione-S-transferase and the levels of lipid peroxidation. | CTD_human |
1 | 0 | Biomarker | C0023418 | leukemia | disease | leukemia | 367 | AR | Androgen receptor | CTD_human | 19,235,587 | Androgen receptor CpG island methylation status in human leukemia cancer cells. | 0.200549 | <span class="gene" id="19235587-0-0-17">Androgen receptor</span> CpG island methylation status in human <span class="disease" id="19235587-0-57-65">leukemia</span> cancer cells. | CTD_human |
null | null | Negative | MESH:D009203 | null | null | MI | 100038033 | null | galectin-3 | null | 28,094,123 | Myocardial and serum galectin-3 expression dynamics in response to the early cardiovascular outcomes after acute MI are not fully elucidated. | null | null | null |
12 | 9 | Biomarker | C0795953 | MASA SYNDROME (disorder) | disease | SPG1 | 3897 | L1CAM | HSAS | CTD_human | 7,920,659 | Here we report mutations of the L1 gene in MASA syndrome and SPG1, in addition to HSAS families. | 0.685495 | Here we report mutations of the L1 gene in <span class="disease" id="7920659-3-43-56">MASA syndrome</span> and <span class="disease" id="7920659-3-61-65">SPG1</span>, in addition to <span class="gene" id="7920659-3-82-86">HSAS</span> families. | CTD_human;ORPHANET;UNIPROT |
6 | 0 | Biomarker | C0033578 | Prostatic Neoplasms | group | prostate tumours | 2100 | ESR2 | ESR2 | CTD_human | 26,443,449 | The mRNA levels of PPFIBP2 and ESR2 are differentially expressed in prostate tumours and paired normal tissues. | 0.228977 | The mRNA levels of PPFIBP2 and <span class="gene" id="26443449-5-31-35">ESR2</span> are differentially expressed in <span class="disease" id="26443449-5-68-84">prostate tumours</span> and paired normal tissues. | CTD_human |
null | null | Negative | MESH:D006948 | null | null | decline of locomotor activity | 53581 | null | Gclc | null | 28,105,938 | Gclc overexpression slowed down the age-dependent decline of locomotor activity and circadian rhythmicity, and resistance to stress treatments. | null | null | null |
2 | 0 | Biomarker | C0086543 | Cataract | disease | cataracts | 5309 | PITX3 | PITX3 | CTD_human | 16,565,358 | Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. | 0.404656 | Heterozygous and homozygous mutations in <span class="gene" id="16565358-0-41-46">PITX3</span> in a large Lebanese family with posterior polar <span class="disease" id="16565358-0-95-104">cataracts</span> and neurodevelopmental abnormalities. | CTD_human;HPO |
24 | 0 | Biomarker | C0002736 | Amyotrophic Lateral Sclerosis | disease | amyotrophic lateral sclerosis | 6647 | SOD1 | SOD1 | CTD_human | 10,930,589 | Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1. | 0.798512 | Increased reactive oxygen species in familial <span class="disease" id="10930589-0-46-75">amyotrophic lateral sclerosis</span> with mutations in <span class="gene" id="10930589-0-94-98">SOD1</span>. | CTD_human;HPO;ORPHANET |
null | null | Negative | MESH:D013927 | null | null | thrombosis | 56760 | null | CLEC-2 | null | 28,028,907 | CLEC-2 depletion prolongs cancer survival by suppressing thrombosis and inflammation. | null | null | null |
null | null | Negative | MESH:D000795 | null | null | Fabry disease | 53947 | null | Gb3 | null | 28,108,302 | We thus investigated relationships between Fabry disease biomarkers (such as globotriaosylceramide (Gb3), globotriaosylsphingosine (lyso-Gb3)/related analogues) and age, gender, enzyme activity, clinical manifestations and severity of the disease in these patients. | null | null | null |
1 | 0 | Biomarker | C0007137 | Squamous cell carcinoma | disease | squamous cell carcinoma | 3066 | HDAC2 | HDAC2 | CTD_human | 21,527,555 | Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. | 0.200549 | Physical association of HDAC1 and <span class="gene" id="21527555-0-34-39">HDAC2</span> with p63 mediates transcriptional repression and tumor maintenance in <span class="disease" id="21527555-0-110-133">squamous cell carcinoma</span>. | CTD_human |
null | null | Negative | MESH:D004342 | null | null | visceral hypersensitivity | 22073 | null | trypsin-3 | null | 28,096,305 | CONCLUSIONS: In IBS, the intestinal epithelium produces and releases the active protease trypsin-3, which is able to signal to enteric neurons and to induce visceral hypersensitivity. | null | null | null |
25 | 0 | Biomarker | C0004153 | Atherosclerosis | disease | atherosclerosis | 348 | APOE | apolipoprotein E | CTD_human | 11,947,894 | Low density lipoprotein receptor deficient (LDLR-KO) and apolipoprotein E deficient (apo E-KO) mice both develop hyperlipidemia and atherosclerosis by different mechanisms. | 0.587329 | Low density lipoprotein receptor deficient (LDLR-KO) and <span class="gene" id="11947894-1-57-73">apolipoprotein E</span> deficient (apo E-KO) mice both develop hyperlipidemia and <span class="disease" id="11947894-1-132-147">atherosclerosis</span> by different mechanisms. | CTD_human;HPO |
null | null | Negative | MESH:D009369 | null | null | tumor | 21929 | null | A20 | null | 28,004,776 | UNASSIGNED: The ubiquitin-modifying enzyme A20, an important negative feedback regulator of NF-kB, impairs the expansion of tumor-specific CD8(+) T cells but augments the proliferation of autoimmune CD4(+) T cells. | null | null | null |
null | null | Negative | MESH:D012162 | null | null | inherited retinal degeneration | 11545 | null | PARP | null | 28,004,814 | This study affirms the role of PARP in inherited retinal degeneration and for the first time shows that a clinically approved PARP inhibitor can prevent photoreceptor degeneration in an RP model. | null | null | null |
2 | 0 | Biomarker | C0152013 | Adenocarcinoma of lung (disorder) | disease | adenocarcinoma of the lung | 1956 | EGFR | EGFR | CTD_human | 22,135,231 | We examined epidermal growth factor receptor (EGFR), Kirsten rate sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2), PIK3CA, v-akt murine thymoma vial oncogene homolog 1 (AKT1), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen-activated protein kinase kinase 1 (MEK1), and anaplastic lymphoma kinase (ALK) in patients with adenocarcinoma of the lung to identify driver mutations. | 0.28 | We examined <span class="gene" id="22135231-4-12-44">epidermal growth factor receptor</span> (<span class="gene" id="22135231-4-46-50">EGFR</span>), Kirsten rate sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2), PIK3CA, v-akt murine thymoma vial oncogene homolog 1 (AKT1), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen-activated protein kinase kinase 1 (MEK1), and anaplastic lymphoma kinase (ALK) in patients with <span class="disease" id="22135231-4-442-468">adenocarcinoma of the lung</span> to identify driver mutations. | CTD_human |
2 | 3 | Biomarker | C0027819 | Neuroblastoma | disease | neuroblastoma | 580 | BARD1 | BARD1 | CTD_human | 19,412,175 | Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. | 0.202198 | Common variations in <span class="gene" id="19412175-0-21-26">BARD1</span> influence susceptibility to high-risk <span class="disease" id="19412175-0-65-78">neuroblastoma</span>. | CTD_human |
1 | 0 | Biomarker | C0024141 | Lupus Erythematosus, Systemic | disease | systemic lupus erythematosus | 1445 | CSK | CSK | CTD_human | 23,042,117 | CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation. | 0.200549 | <span class="gene" id="23042117-0-0-3">CSK</span> regulatory polymorphism is associated with <span class="disease" id="23042117-0-47-75">systemic lupus erythematosus</span> and influences B-cell signaling and activation. | CTD_human |
null | null | Negative | MESH:D009202 | null | null | cardiomyopathy | 64529 | null | CTSB | null | 28,074,340 | However, the information regarding the role of cysteine cathepsin L (CTSL) and cathepsin B (CTSB) in dilated cardiomyopathy (DCM) is limited. | null | null | null |
4 | 0 | Biomarker | C0011881 | Diabetic Nephropathy | disease | diabetic nephropathy | 1636 | ACE | angiotensin I--converting enzyme | CTD_human | 7,909,524 | Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I--converting enzyme gene. | 0.416577 | Genetic predisposition to <span class="disease" id="7909524-0-26-46">diabetic nephropathy</span>. Evidence for a role of the <span class="gene" id="7909524-0-75-107">angiotensin I--converting enzyme</span> gene. | CTD_human |
1 | 0 | Biomarker | C0004096 | Asthma | disease | asthmatic | 3553 | IL1B | IL-1 | CTD_human | 9,176,529 | Effect of inhaled glucocorticoids on IL-1 beta and IL-1 receptor antagonist (IL-1 ra) expression in asthmatic bronchial epithelium. | 0.236144 | Effect of inhaled glucocorticoids on <span class="gene" id="9176529-0-37-46">IL-1 beta</span> and <span class="gene" id="9176529-0-51-55">IL-1</span> receptor antagonist (IL-1 ra) expression in <span class="disease" id="9176529-0-100-109">asthmatic</span> bronchial epithelium. | CTD_human |
null | null | Negative | MESH:D003424 | null | null | CD | 170750 | null | SAMP | null | 28,125,562 | Recently, we determined that the genetic deletion of the NOD2 gene decreased the severity of Th2-mediated chronic inflammation in a mouse strain characterized by suffering CD-like spontaneous progressive ileitis (SAMP1Yit/Fc; SAMP). | null | null | null |
null | null | Negative | MESH:D013119 | null | null | SCI | 12367 | null | caspase-3 | null | 28,210,902 | Deletion of Mst1 in mice reduced apoptosis via suppressing cytochrome c release and caspase-3 activation following SCI. | null | null | null |
null | null | Negative | MESH:C536751 | null | null | WT-1 | 3855;54474 | null | CK 7/20 | null | 28,021,228 | CONCLUSIONS: Uniform and limited IHC including CK 7/20; CDX-2, WT-1 and Calretinin are the most helpful first tier IHC in determining the cancer profile and choosing the best treatment strategy for isolated carcinomatosis CUP patients. | null | null | null |
null | null | Negative | MESH:D030342 | null | null | autosomal recessive disorder | 1589 | null | CYP21A2 | null | 28,161,392 | UNASSIGNED: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is an autosomal recessive disorder caused by mutations in the CYP21A2 gene. | null | null | null |
null | null | Negative | MESH:D006623 | null | null | VHL | 2272 | null | FHIT | null | 28,143,107 | The gene probes chosen for this analysis were; VHL, FHIT, FGFR1/3, PDGFb, PDGFRb, EGFR, MYC and IGH@. | null | null | null |
1 | 0 | Biomarker | C0339573 | Glaucoma, Primary Open Angle | disease | primary open-angle glaucoma | 64778 | FNDC3B | FNDC3B | CTD_human | 23,291,589 | FNDC3B was also associated with primary open-angle glaucoma (P = 5.6 × 10(-4); tested in 3 cohorts with 2,979 cases and 7,399 controls). | 0.200549 | <span class="gene" id="23291589-4-0-6">FNDC3B</span> was also associated with <span class="disease" id="23291589-4-32-59">primary open-angle glaucoma</span> (P = 5.6 × 10(-4); tested in 3 cohorts with 2,979 cases and 7,399 controls). | CTD_human |
null | null | Negative | MESH:D001014 | null | null | aortic aneurysm | 74499 | null | SOST | null | 28,062,506 | The aim of this study was to assess the role of SOST in aortic aneurysm (AA) and atherosclerosis using human samples, a mouse model, and in vitro investigations. | null | null | null |
1 | 2 | Biomarker | C0011615 | Dermatitis, Atopic | disease | atopic dermatitis | 22891 | ZNF365 | ZNF365 | CTD_human | 23,042,114 | On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 × 10(-20)), OR10A3-NLRP10 (P = 1.54 × 10(-22)), GLB1 (P = 2.77 × 10(-16)), CCDC80 (P = 1.56 × 10(-19)), CARD11 (P = 7.83 × 10(-9)), ZNF365 (P = 5.85 × 10(-20)) and CYP24A1-PFDN4 (P = 1.65 × 10(-8)). | 0.2 | On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with <span class="disease" id="23042114-2-130-147">atopic dermatitis</span> and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 × 10(-20)), OR10A3-NLRP10 (P = 1.54 × 10(-22)), GLB1 (P = 2.77 × 10(-16)), CCDC80 (P = 1.56 × 10(-19)), CARD11 (P = 7.83 × 10(-9)), <span class="gene" id="23042114-2-484-490">ZNF365</span> (P = 5.85 × 10(-20)) and CYP24A1-PFDN4 (P = 1.65 × 10(-8)). | CTD_human |
null | null | Negative | MESH:D054221 | null | null | Miller-Dieker syndrome | 1398 | null | CRK | null | 28,186,603 | Both deletions have overlapped with the critical region of Miller-Dieker syndrome (MDS) and involved candidate genes such as PAFAH1B1, YWHAE and CRK. | null | null | null |
null | null | Negative | MESH:D000230 | null | null | adenocarcinomas | 109264 | null | ME3 | null | 28,174,172 | The chromosome 18q21 deletion in nearly one third of pancreatic adenocarcinomas eliminates not only the tumor suppressor SMAD4, but also neighboring genes with important cellular roles, such as ME2 This is tolerated by cancer cells only because ME2 has a functionally redundant paralog, ME3, elsewhere in the genome. | null | null | null |
null | null | Negative | MESH:D001201 | null | null | ascites | 15977 | null | IFN-b | null | 28,129,467 | Interferon-b (IFN-b) has been used to treat several cancer indications; however, little is known about the efficacy of IFN-b on malignant ascites. | null | null | null |
null | null | Negative | MESH:D007249 | null | null | Inflammation | 21926 | null | TNF | null | 28,187,456 | Inflammation and pro-inflammatory cytokines produced by Th1 and Th17 cells like IL-6, TNF, IL-17 and IL-23 promote the development and growth of colorectal cancer (CRC). | null | null | null |
3 | 0 | Therapeutic | C2239176 | Liver carcinoma | disease | HCC | 3439 | IFNA1 | IFN-alpha | CTD_human | 18,665,156 | These results suggest that IFN-alpha gene therapy is a promising strategy to treat HCC patients who have concomitant liver cirrhosis. | 0.207692 | These results suggest that <span class="gene" id="18665156-8-27-36">IFN-alpha</span> gene therapy is a promising strategy to treat <span class="disease" id="18665156-8-83-86">HCC</span> patients who have concomitant liver cirrhosis. | CTD_human |
2 | 0 | Therapeutic | C0023473 | Myeloid Leukemia, Chronic | disease | chronic myeloid leukemia | 240 | ALOX5 | Alox5 | CTD_human | 19,503,090 | Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. | 0.201374 | Loss of the <span class="gene" id="19503090-0-12-17">Alox5</span> gene impairs leukemia stem cells and prevents <span class="disease" id="19503090-0-64-88">chronic myeloid leukemia</span>. | CTD_human |
68 | 0 | Therapeutic | C0020538 | Hypertensive disease | group | hypertension | 5443 | POMC | ACTH | CTD_human | 17,324,744 | Given that BH(4) failed to prevent ACTH or Dex hypertension, folic acid is unlikely to be acting through increased BH(4) production. | 0.203846 | Given that BH(4) failed to prevent <span class="gene" id="17324744-13-35-39">ACTH</span> or Dex <span class="disease" id="17324744-13-47-59">hypertension</span>, folic acid is unlikely to be acting through increased BH(4) production. | CTD_human |
null | null | Negative | MESH:D003875 | null | null | eruptions | 109880 | null | BRAF | null | 28,188,628 | Differential diagnosis can be difficult with CMPE provoked by other therapies as was seen in our comparison group of anti-BRAF-induced eruptions. | null | null | null |
1 | 0 | Biomarker | C0014556 | Epilepsy, Temporal Lobe | disease | temporal lobe epilepsy | 7421 | VDR | vitamin D receptor | CTD_human | 18,534,255 | Expression of vitamin D receptor mRNA in the hippocampal formation of rats submitted to a model of temporal lobe epilepsy induced by pilocarpine. | 0.200549 | Expression of <span class="gene" id="18534255-0-14-32">vitamin D receptor</span> mRNA in the hippocampal formation of rats submitted to a model of <span class="disease" id="18534255-0-99-121">temporal lobe epilepsy</span> induced by pilocarpine. | CTD_human |
2 | 0 | Biomarker | C0853897 | Diabetic Cardiomyopathies | disease | diabetic cardiomyopathy | 186 | AGTR2 | AT2 | CTD_human | 16,025,228 | A high expression of AT2 may accelerate the apoptosis of cardiomyocytes in diabetic rats and play a role in precipitating diabetic cardiomyopathy; taurine may protect diabetic rats from developing cardiomyopathy also by downregulating AT2 receptors. | 0.2 | A high expression of AT2 may accelerate the apoptosis of cardiomyocytes in diabetic rats and play a role in precipitating <span class="disease" id="16025228-19-122-145">diabetic cardiomyopathy</span>; taurine may protect diabetic rats from developing cardiomyopathy also by downregulating <span class="gene" id="16025228-19-235-238">AT2</span> receptors. | CTD_human |
1 | 0 | Biomarker | C0027819 | Neuroblastoma | disease | neuroblastoma | 26038 | CHD5 | CHD5 | CTD_human | 26,121,086 | Recurrent alterations at relapse included mutations in the putative CHD5 neuroblastoma tumor suppressor, chromosome 9p losses, DOCK8 mutations, inactivating mutations in PTPN14 and a relapse-specific activity pattern for the PTPN14 target YAP. | 0.203571 | Recurrent alterations at relapse included mutations in the putative <span class="gene" id="26121086-6-68-72">CHD5</span> <span class="disease" id="26121086-6-73-86">neuroblastoma</span> tumor suppressor, chromosome 9p losses, DOCK8 mutations, inactivating mutations in PTPN14 and a relapse-specific activity pattern for the PTPN14 target YAP. | CTD_human |
null | null | Negative | MESH:D014947 | null | null | neuropathic injury | 29251 | null | thrombin | null | 28,059,686 | CONCLUSIONS The findings of this study suggest a potent role for spinal thrombin and its activation of PAR1 in pain onset following neuropathic injury. | null | null | null |
1 | 0 | Biomarker | C0014859 | Esophageal Neoplasms | group | esophageal cancer | 406991 | MIR21 | miR-21 | CTD_human | 21,248,297 | Using 98 formalin-fixed, paraffin-embedded samples obtained from patients with esophageal cancer who had received preoperative chemotherapy followed by surgery, we measured expression levels of several miRNAs that are considered to be involved in the regulation of stem cell function (e.g., let-7a, let-7g, miR-21, miR-134, miR-145, miR-155, miR-200c, miR-203, and miR-296) by real-time reverse transcriptase PCR. | 0.203846 | Using 98 formalin-fixed, paraffin-embedded samples obtained from patients with <span class="disease" id="21248297-2-79-96">esophageal cancer</span> who had received preoperative chemotherapy followed by surgery, we measured expression levels of several miRNAs that are considered to be involved in the regulation of stem cell function (e.g., let-7a, let-7g, <span class="gene" id="21248297-2-307-313">miR-21</span>, miR-134, miR-145, miR-155, miR-200c, miR-203, and miR-296) by real-time reverse transcriptase PCR. | CTD_human |
null | null | Negative | MESH:D018149 | null | null | OGD | 12125 | null | Bim | null | 28,093,478 | Silencing of Malat1 also significantly aggravated OGD-induced expression of the proapoptotic factor Bim and proinflammatory cytokines MCP-1, IL-6, and E-selectin. | null | null | null |
null | null | Negative | MESH:C565957 | null | null | ALS | 6647 | null | SOD1 | null | 28,126,529 | The example examined in this review is the ALS associated protein SOD1 that apparently retains its in-vitro properties in vivo. | null | null | null |
null | null | Negative | MESH:D008414 | null | null | bovine mastitis | 280846 | null | lactoferrin | null | 28,169,551 | This minireview describes lactoferrin research concerning bovine mastitis. | null | null | null |
null | null | Negative | MESH:D005355 | null | null | fibrosis | 24498 | null | IL-6 | null | 28,115,235 | Pirfenidone, a recently approved treatment for idiopathic pulmonary fibrosis (IPF), significantly counteracted bleomycin-induced pro-fibrotic genes expression, but did not exert significant effects on IL-1b and IL-6. | null | null | null |
null | null | Negative | MESH:D016066 | null | null | MPE | 238 | null | ALK | null | 28,018,791 | CASE DESCRIPTION: A 50-year old man diagnosed with stage IV lung adenocarcinoma presented with MPE and an ALK fusion gene mutation. | null | null | null |
1 | 0 | Biomarker | C0004352 | Autistic Disorder | disease | autistic | 3346 | HTN1 | histatin 1 | CTD_human | 19,367,726 | Phosphorylation level of four specific salivary phospho-peptides, namely statherin, histatin 1 (both, p < 0.0001) and acidic proline-rich proteins (both entire and truncated isoforms) (p < 0.005) was found significantly lower in autistic patients, with hypo-phosphorylation of at least one peptide observed in 18 ASD subjects (66%). | 0.2 | Phosphorylation level of four specific salivary phospho-peptides, namely statherin, <span class="gene" id="19367726-2-84-94">histatin 1</span> (both, p < 0.0001) and acidic proline-rich proteins (both entire and truncated isoforms) (p < 0.005) was found significantly lower in <span class="disease" id="19367726-2-229-237">autistic</span> patients, with hypo-phosphorylation of at least one peptide observed in 18 ASD subjects (66%). | CTD_human |
null | null | Negative | MESH:D007863 | null | null | PAT | 55625 | null | DHHC7 | null | 28,057,756 | Here we report that among 23 mammalian DHHC proteins, DHHC7 is the major Glut4 PAT, based on evidence that ectopic expression of DHHC7 increased Glut4 palmitoylation, whereas DHHC7 knockdown in 3T3-L1 adipocytes and DHHC7 KO in adipose tissue and muscle decreased Glut4 palmitoylation. | null | null | null |
null | null | Negative | MESH:D030342 | null | null | progressive disease | 2247 | null | FGF2 | null | 28,022,551 | Pts with RECIST response continued on open-label B, those with progressive disease (PD) went off study, and those with stable disease (SD) were randomized 1:1 to B or placebo (P), stratified by FGF2 expression (IHC + or -), until PD or unacceptable toxicity. | null | null | null |
69 | 0 | Biomarker | C0020538 | Hypertensive disease | group | hypertension | 183 | AGT | angiotensin II | CTD_human | 20,231,528 | Sex chromosome effects unmasked in angiotensin II-induced hypertension. | 0.52 | Sex chromosome effects unmasked in <span class="gene" id="20231528-0-35-49">angiotensin II</span>-induced <span class="disease" id="20231528-0-58-70">hypertension</span>. | CTD_human |
1 | 0 | Biomarker | C0011849 | Diabetes Mellitus | group | diabetes | 3667 | IRS1 | IRS-1 | CTD_human | 10,591,678 | Besides the increased frequency of diabetes, carriers showed a more atherogenic lipid profile, suggesting a potential role of the IRS-1 gene in the pathogenesis of lipid abnormalities associated with CAD. | 0.210099 | Besides the increased frequency of <span class="disease" id="10591678-15-35-43">diabetes</span>, carriers showed a more atherogenic lipid profile, suggesting a potential role of the <span class="gene" id="10591678-15-130-135">IRS-1</span> gene in the pathogenesis of lipid abnormalities associated with CAD. | CTD_human |
1 | 0 | Biomarker | C0027051 | Myocardial Infarction | disease | MI | 7137 | TNNI3 | cTnI | CTD_human | 12,359,538 | Most patients with cTnI elevations meet CK-MB criteria for MI, as well as have a high incidence of underlying significant disease. | 0.206015 | Most patients with <span class="gene" id="12359538-11-19-23">cTnI</span> elevations meet CK-MB criteria for <span class="disease" id="12359538-11-59-61">MI</span>, as well as have a high incidence of underlying significant disease. | CTD_human |
4 | 0 | Biomarker | C0020473 | Hyperlipidemia | disease | hyperlipidemia | 348 | APOE | apolipoprotein(E | CTD_human | 12,871,831 | In aortae from apolipoprotein(E)-deficient mice (apoE(0)) with hyperlipidemia and atherosclerosis, superoxide production is largely derived from NADPH oxidase. | 0.385767 | In aortae from <span class="gene" id="12871831-7-15-31">apolipoprotein(E</span>)-deficient mice (apoE(0)) with <span class="disease" id="12871831-7-63-77">hyperlipidemia</span> and atherosclerosis, superoxide production is largely derived from NADPH oxidase. | CTD_human |
null | null | Negative | MESH:D016720 | null | null | Pneumocystis | 3239 | null | SPD1 | null | 28,012,778 | RESULTS: Normal mice infected with Pneumocystis mounted a serum IgG antibody response to SPD1. | null | null | null |
1 | 0 | Biomarker | C0020538 | Hypertensive disease | group | hypertension | 7421 | VDR | vitamin D receptor | CTD_human | 11,335,187 | Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes. | 0.207012 | Associations of blood pressure and <span class="disease" id="11335187-0-35-47">hypertension</span> with lead dose measures and polymorphisms in the <span class="gene" id="11335187-0-97-115">vitamin D receptor</span> and delta-aminolevulinic acid dehydratase genes. | CTD_human |
1 | 0 | Biomarker | C0345967 | Malignant mesothelioma | disease | MM | 596 | BCL2 | bcl-2 | CTD_human | 16,850,164 | This speculation was partially confirmed by the detection of elevated bcl-2 expression levels in CD4 + peripheral blood T cells from patients with MM compared with those from patients with ASB or healthy donors. | 0.200275 | This speculation was partially confirmed by the detection of elevated <span class="gene" id="16850164-5-70-75">bcl-2</span> expression levels in CD4 + peripheral blood T cells from patients with <span class="disease" id="16850164-5-147-149">MM</span> compared with those from patients with ASB or healthy donors. | CTD_human |
null | null | Negative | MESH:C566273 | null | null | neutrophil serine proteases | 13035 | null | cathepsin G | null | 28,192,517 | There is now renewed attention on neutrophils and neutrophil serine proteases (NSPs) such as neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CG) in inflammation and autoimmunity. | null | null | null |
null | null | Negative | MESH:D017695 | null | null | TMA | 51438 | null | MAGEC2 | null | 28,021,061 | The TMA was stained with a panel of antibodies against the following CTAg: MAGE-A1, MAGE-A3/4, NY-ESO-1, GAGE, SAGE1, NXF2/CT39, ACTL8/CT57, MAGEC1/CT7, MAGEC2/CT10 and CT45. | null | null | null |
null | null | Negative | MESH:D053632 | null | null | SCID | 1822 | null | NOD | null | 28,030,837 | Accordingly, the senescent HCT116 cells treated with BAF A1 when injected into NOD/SCID mice formed tumors, in contrast to the controls.Our results suggest that senescent cancer cells that appear during therapy, can be considered as dormant cells that contribute to cancer re-growth, when chemotherapeutic treatment is stopped. | null | null | null |
null | null | Negative | MESH:C536528 | null | null | LPS | 280943 | null | TNFa | null | 28,166,928 | Functional analysis showed that the same haplotype was a more potent inducer of IL8 expression in BEND cells in response to LPS and TNFa stimulation. | null | null | null |
1 | 0 | Biomarker | C0004096 | Asthma | disease | asthma | 8989 | TRPA1 | TRPA1 | CTD_human | 19,458,046 | TRPA1 may represent a promising pharmacological target for the treatment of asthma and other allergic inflammatory conditions. | 0.2 | <span class="gene" id="19458046-13-0-5">TRPA1</span> may represent a promising pharmacological target for the treatment of <span class="disease" id="19458046-13-76-82">asthma</span> and other allergic inflammatory conditions. | CTD_human |
null | null | Negative | MESH:C562645 | null | null | ALP | 12393 | null | runt-related transcription factor 2 | null | 28,082,041 | Collectively, our findings indicate that curculactones A or B induced osteoblast differentiation through osteogenic expression of genes such as distal-less homeobox 5 (Dlx5), runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OC). | null | null | null |
null | null | Negative | MESH:D007249 | null | null | inflammation | 331623 | null | bEnd.3 | null | 28,131,884 | Transmission electron microscopy and blocking experiments revealed that during inflammation VSOP were endocytosed by bEnd.3. | null | null | null |
1 | 1 | Biomarker | C1863753 | LIMB-MAMMARY SYNDROME | disease | LMS | 8626 | TP63 | p63 | CTD_human | 11,462,173 | We performed p63 mutation analysis in a sample of 43 individuals and families affected with EEC syndrome, in 35 individuals affected with SHFM, and in three families with the EEC-like condition limb-mammary syndrome (LMS), which is characterized by ectrodactyly, cleft palate, and mammary-gland abnormalities. | 0.400549 | We performed <span class="gene" id="11462173-2-13-16">p63</span> mutation analysis in a sample of 43 individuals and families affected with EEC syndrome, in 35 individuals affected with SHFM, and in three families with the EEC-like condition <span class="disease" id="11462173-2-194-215">limb-mammary syndrome</span> (<span class="disease" id="11462173-2-217-220">LMS</span>), which is characterized by ectrodactyly, cleft palate, and mammary-gland abnormalities. | CTD_human;ORPHANET |
1 | 0 | Therapeutic | C0007134 | Renal Cell Carcinoma | disease | renal cell carcinoma | 3440 | IFNA2 | interferon alpha-2B | CTD_human | 8,886,046 | [Combination therapy with 5-fluorouracil (5-FU), cisplatin (CDDP) and interferon alpha-2B (IFN alpha-2B) for advanced renal cell carcinoma]. | 0.200549 | [Combination therapy with 5-fluorouracil (5-FU), cisplatin (CDDP) and <span class="gene" id="8886046-0-70-89">interferon alpha-2B</span> (IFN alpha-2B) for advanced <span class="disease" id="8886046-0-118-138">renal cell carcinoma</span>]. | CTD_human |
null | null | Negative | MESH:D018235 | null | null | ASM | 79784 | null | myosin | null | 28,126,731 | Ultimately, this pressurizing stretches the ASM and may disturb the acto-myosin cross-bridges in a manner similar to LO; however, it is of a static rather than dynamic nature. | null | null | null |
3 | 0 | Biomarker | C0008370 | Cholestasis | disease | cholestasis | 1244 | ABCC2 | Mrp2 | CTD_human | 10,869,290 | Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats. | 0.282198 | <span class="gene" id="10869290-0-0-4">Mrp2</span> is essential for estradiol-17beta(beta-D-glucuronide)-induced <span class="disease" id="10869290-0-67-78">cholestasis</span> in rats. | CTD_human |
13 | 31 | Biomarker | C0004779 | Basal Cell Nevus Syndrome | disease | nevoid basal cell carcinoma syndrome | 5727 | PTCH1 | PTCH1 | CTD_human | 25,876,211 | The Hh signaling pathway is involved in the pathogenesis of several tumors, including nevoid basal cell carcinoma syndrome that is associated with an alteration of the patched-1 (PTCH1) gene. | 0.73619 | The Hh signaling pathway is involved in the pathogenesis of several tumors, including <span class="disease" id="25876211-4-86-122">nevoid basal cell carcinoma syndrome</span> that is associated with an alteration of the <span class="gene" id="25876211-4-168-177">patched-1</span> (<span class="gene" id="25876211-4-179-184">PTCH1</span>) gene. | CTD_human;ORPHANET;UNIPROT |
null | null | Negative | MESH:D009369 | null | null | tumor | 16153 | null | IL-10 | null | 28,068,646 | Differences in nitric oxide (NO), tumor necrosis factor alpha (TNF-a), interleukin-1 beta (IL-1b), IL-6, and IL-10 were found in the bronchoalveolar lavage fluid (BALF) 6h after LPS-induced lung injury. | null | null | null |
null | null | Negative | MESH:D030342 | null | null | progressive disease | 28509 | null | DM1 | null | 28,146,686 | Patients (pts) received T-DM1 (3.6 mg/kg IV q3w) or X (1,000 mg/m(2)PO bid, days 1-14 q3w) + L (1,250 mg PO daily) until progressive disease (PD) or unmanageable toxicity. | null | null | null |
8 | 1 | Biomarker | C0001973 | Alcoholic Intoxication, Chronic | disease | alcoholism | 125 | ADH1B | ADH1B | CTD_human | 17,590,986 | To date, the only genes that have been consistently replicated across racial and ethnic groups to influence alcoholism vulnerability are polymorphisms in the alcohol-metabolizing enzymes, i.e. cytosolic alcohol dehydrogenase 1B (ADH1B) and mitochondrial aldehyde dehydrogenase 2 (ALDH2). | 0.509396 | To date, the only genes that have been consistently replicated across racial and ethnic groups to influence <span class="disease" id="17590986-1-108-118">alcoholism</span> vulnerability are polymorphisms in the alcohol-metabolizing enzymes, i.e. cytosolic <span class="gene" id="17590986-1-203-227">alcohol dehydrogenase 1B</span> (<span class="gene" id="17590986-1-229-234">ADH1B</span>) and mitochondrial aldehyde dehydrogenase 2 (ALDH2). | CTD_human;PSYGENET |
null | null | Negative | MESH:D004827 | null | null | epilepsy | 20272 | null | NAX | null | 28,098,336 | SIGNIFICANCE: These studies further suggest the potential utility of NAX 810-2 as a novel therapy for epilepsy. | null | null | null |
2 | 0 | Biomarker | C0014544 | Epilepsy | disease | epilepsy | 2903 | GRIN2A | NR2A | CTD_human | 20,890,276 | Either GRIN2B or GRIN2A, encoding the NMDA receptor subunits NR2B and NR2A, was found to be disrupted by chromosome translocation breakpoints in individuals with mental retardation and/or epilepsy. | 0.404121 | Either GRIN2B or <span class="gene" id="20890276-3-17-23">GRIN2A</span>, encoding the NMDA receptor subunits NR2B and <span class="gene" id="20890276-3-70-74">NR2A</span>, was found to be disrupted by chromosome translocation breakpoints in individuals with mental retardation and/or <span class="disease" id="20890276-3-188-196">epilepsy</span>. | CTD_human;HPO |
null | null | Negative | MESH:D009369 | null | null | Neuroendocrine neoplasms | 30956 | null | SDH | null | 28,036,268 | Neuroendocrine neoplasms such as paragangliomas (PGLs) are particularly appealing for understanding the cancer metabolic adjustments because of their associations with deregulations of metabolic enzymes, such as succinate dehydrogenase (SDH), and the von Hippel Lindau (VHL) gene involved in HIF-1a stabilization. | null | null | null |
null | null | Negative | MESH:D009369 | null | null | cancer | 21926 | null | TNF-a | null | 28,089,732 | ALOX15 suppressed the TNF-a, IL-1b/NF-kB, and IL-6/STAT3 signaling pathways, which play major roles in promotion of colorectal cancer by chronic inflammation. | null | null | null |
null | null | Negative | MESH:D004681 | null | null | EAE | 18024 | null | nuclear factor-E2-related factor | null | 28,050,123 | To address this gap in research, we sought to determine how a deficiency in the master antioxidant transcription factor (using nuclear factor-E2-related factor [Nrf2]-deficient mice) affects visual pathology in the EAE model. | null | null | null |
1 | 0 | Biomarker | C0002452 | Amelogenesis Imperfecta | disease | amelogenesis imperfecta | 4054 | LTBP3 | LTBP3 | CTD_human | 25,669,657 | Mutations in the latent TGF-beta binding protein 3 (LTBP3) gene cause brachyolmia with amelogenesis imperfecta. | 0.400275 | Mutations in the <span class="gene" id="25669657-0-17-50">latent TGF-beta binding protein 3</span> (<span class="gene" id="25669657-0-52-57">LTBP3</span>) gene cause brachyolmia with <span class="disease" id="25669657-0-87-110">amelogenesis imperfecta</span>. | CTD_human;HPO |
1 | 0 | Biomarker | C0079744 | Diffuse Large B-Cell Lymphoma | disease | DLBCL | 8085 | KMT2D | MLL2 | CTD_human | 21,804,550 | This analysis also revealed mutations in genes not previously implicated in DLBCL pathogenesis, including those regulating chromatin methylation (MLL2; 24% of samples) and immune recognition by T cells. | 0.201099 | This analysis also revealed mutations in genes not previously implicated in <span class="disease" id="21804550-4-76-81">DLBCL</span> pathogenesis, including those regulating chromatin methylation (<span class="gene" id="21804550-4-146-150">MLL2</span>; 24% of samples) and immune recognition by T cells. | CTD_human |
1 | 0 | Biomarker | C0002940 | Aneurysm | disease | aneurysms | 4312 | MMP1 | MMP-1 | CTD_human | 21,742,783 | In this study, we demonstrate that matrix metalloproteinase-1 (MMP-1), a collagenase expressed in atherosclerosis and aneurysms but not in the normal vessel wall, is induced in the aortic endothelium of rabbits exposed to cigarette smoke. | 0.200549 | In this study, we demonstrate that <span class="gene" id="21742783-2-35-61">matrix metalloproteinase-1</span> (<span class="gene" id="21742783-2-63-68">MMP-1</span>), a collagenase expressed in atherosclerosis and <span class="disease" id="21742783-2-118-127">aneurysms</span> but not in the normal vessel wall, is induced in the aortic endothelium of rabbits exposed to cigarette smoke. | CTD_human |
2 | 0 | Biomarker | C0162557 | Liver Failure, Acute | disease | fulminant hepatic failure | 2638 | GC | Gc-globulin | CTD_human | 8,666,322 | Admission levels of serum Gc-globulin: predictive value in fulminant hepatic failure. | 0.205466 | Admission levels of serum <span class="gene" id="8666322-0-26-37">Gc-globulin</span>: predictive value in <span class="disease" id="8666322-0-59-84">fulminant hepatic failure</span>. | CTD_human |
null | null | Negative | MESH:D056486 | null | null | Hepatic malondialdehyde | 58962 | null | glutathione S-transferase | null | 28,065,777 | Hepatic malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), glutathione S-transferase (GST), and nitric monoxide (NO) in liver were measured to explore the possible protective mechanisms. | null | null | null |
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