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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
null | null | Negative | MESH:D005234 | null | null | hepatic steatosis | 53791 | null | Toll-like receptor 5 | null | 28,090,564 | For example, mice lacking the flagellin receptor Toll-like receptor 5 (TLR5) show microbial dysbiosis and predisposition to high-fat diet (HFD)-induced hepatic steatosis. | null | null | null |
null | null | Negative | MESH:D000860 | null | null | hypoxia | 22339 | null | vascular endothelial growth factor | null | 28,052,006 | The miR-21 expression was positively correlated with both the mRNA and protein level of key angiogenic factors including vascular endothelial growth factor (VEGF)-A and hypoxia-inducible factor-1a (HIF-1a). | null | null | null |
null | null | Negative | MESH:D010146 | null | null | different pain | 12965 | null | NOP | null | 28,116,100 | Collectively the present results confirm and extend previous finding demonstrating that cebranopadol, by acting as mixed NOP/opioid receptor agonist, elicits robust analgesic effects in different pain models. | null | null | null |
null | null | Negative | MESH:D017544 | null | null | AbdoMinal aortic anEurysm | 50968 | null | FAME | null | 28,049,491 | METHODS/DESIGN: Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME) is a multicentre, randomised, double-blind, placebo-controlled clinical trial to assess the effect of orally administered therapy with fenofibrate on key pathological markers of AAA in patients undergoing open AAA repair. | null | null | null |
64 | 0 | Therapeutic | C0002871 | Anemia | disease | anaemia | 2056 | EPO | Epo | CTD_human | 2,206,997 | These results suggest that rHu Epo might be useful for the therapy of anaemia associated with anticancer chemotherapy. | 0.24092 | These results suggest that rHu <span class="gene" id="2206997-6-31-34">Epo</span> might be useful for the therapy of <span class="disease" id="2206997-6-70-77">anaemia</span> associated with anticancer chemotherapy. | CTD_human |
2 | 0 | Biomarker | C0024117 | Chronic Obstructive Airway Disease | disease | COPD | 3066 | HDAC2 | HDAC2 | CTD_human | 18,421,014 | Histone deacetylase-2 (HDAC2), a critical component of the corticosteroid anti-inflammatory action, is impaired in lungs of patients with COPD and correlates with disease severity. | 0.282747 | <span class="gene" id="18421014-2-0-21">Histone deacetylase-2</span> (<span class="gene" id="18421014-2-23-28">HDAC2</span>), a critical component of the corticosteroid anti-inflammatory action, is impaired in lungs of patients with <span class="disease" id="18421014-2-138-142">COPD</span> and correlates with disease severity. | CTD_human |
null | null | Negative | MESH:C566530 | null | null | BSND | 2706 | null | GJB2 | null | 28,012,523 | To investigate the underlying mutations in a Chinese patient with Bartter syndrome type IV, genetic analysis of BSND, CLCNKA, CLCNKB and GJB2 were performed by polymerase chain reaction and direct sequencing. | null | null | null |
2 | 0 | Biomarker | C0033860 | Psoriasis | disease | psoriasis | 2706 | GJB2 | GJB2 | CTD_human | 20,953,187 | We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10??) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10?²¹) in the European studies. | 0.203506 | We identified six new susceptibility loci associated with <span class="disease" id="20953187-2-58-67">psoriasis</span> in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, <span class="gene" id="20953187-2-141-145">GJB2</span>, SERPINB8 and ZNF816A (combined P < 5 × 10??) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10?²¹) in the European studies. | CTD_human |
null | null | Negative | MESH:D004833 | null | null | temporal lobe epilepsy | 24257 | null | CeA | null | 28,060,294 | We administer pilocarpine into the left central nucleus of the amygdala (CeA) to simulate focal temporal lobe epilepsy (TLE) in rats. | null | null | null |
1 | 0 | Therapeutic | C0030193 | Pain | phenotype | pain | 3060 | HCRT | orexin | CTD_human | 16,202,530 | Furthermore we studied effects of histamine H1 and H2 receptor antagonists on orexin A-produced antinociception in C57BL/6 mice.The antinociceptive effects of i.c.v. orexin A were greater in histamine H1 receptor or H2 receptor knockout mice than in the wild-type mice in all four assays of pain. | 0.200275 | Furthermore we studied effects of histamine H1 and H2 receptor antagonists on <span class="gene" id="16202530-6-78-84">orexin</span> A-produced antinociception in C57BL/6 mice.The antinociceptive effects of i.c.v. <span class="gene" id="16202530-6-166-172">orexin</span> A were greater in histamine H1 receptor or H2 receptor knockout mice than in the wild-type mice in all four assays of <span class="disease" id="16202530-6-291-295">pain</span>. | CTD_human |
null | null | Negative | MESH:D007239 | null | null | infection | 281246 | null | IL-10 | null | 28,159,234 | In addition, these two stages displayed lower reactivity to IL-10; which suggests a deficit of anti-inflammatory cytokines, suppressed immunity and persistence of the infection. | null | null | null |
null | null | Negative | MESH:D009369 | null | null | tumors | 12505 | null | CD44 | null | 28,098,914 | miR-647 also reduced the expression levels of genes associated with proliferation and metastasis in tumors, including ANK2, FAK, MMP2, MMP12, CD44 and SNAIL1. | null | null | null |
null | null | Negative | MESH:D003866 | null | null | depression | 12350;12346 | null | CA3-CA1 | null | 28,193,523 | Here we find that a systemic administration of the FAAH inhibitor PF3845 or an intra-CA1 application of AEA elicits an in vivo long-term depression (LTD) at excitatory glutamatergic CA3-CA1 synapses of the hippocampus. | null | null | null |
1 | 0 | Biomarker | C0007137 | Squamous cell carcinoma | disease | squamous cell carcinomas | 29108 | PYCARD | TMS1 | CTD_human | 16,778,195 | Hypermethylation of ASC/TMS1 is also associated with invasive cancers (41 of 152 or 27.0% of all lung cancer types) with variation in incidence between histopathologic types including 32.1% (26 of 81) of adenocarcinomas, 13.2% (7 of 53) of squamous cell carcinomas, 38.5% (5 of 13) of large-cell carcinomas, and 60% (3 of 5) of small-cell lung cancers. | 0.200275 | Hypermethylation of <span class="gene" id="16778195-5-20-23">ASC</span>/<span class="gene" id="16778195-5-24-28">TMS1</span> is also associated with invasive cancers (41 of 152 or 27.0% of all lung cancer types) with variation in incidence between histopathologic types including 32.1% (26 of 81) of adenocarcinomas, 13.2% (7 of 53) of <span class="disease" id="16778195-5-240-264">squamous cell carcinomas</span>, 38.5% (5 of 13) of large-cell carcinomas, and 60% (3 of 5) of small-cell lung cancers. | CTD_human |
null | null | Negative | MESH:D008171 | null | null | pulmonary alveoli | 29467 | null | CHOP | null | 28,081,472 | Morphological measurements showed that protein BAX and CHOP accumulated in the alveolar epithelium and the alveolar walls with epithelium were damaged and that the number of pulmonary alveoli decreased. | null | null | null |
2 | 0 | Biomarker | C0007222 | Cardiovascular Diseases | group | CVD | 7412 | VCAM1 | VCAM1 | CTD_human | 25,575,156 | Of the 170 SNPs tested, multiplicative interactions between well-water arsenic and two SNPs, rs281432 in ICAM1 (padj = 0.0002) and rs3176867 in VCAM1 (padj = 0.035), were significant for CVD after adjustment for multiple testing. | 0.209796 | Of the 170 SNPs tested, multiplicative interactions between well-water arsenic and two SNPs, rs281432 in ICAM1 (padj = 0.0002) and rs3176867 in <span class="gene" id="25575156-6-144-149">VCAM1</span> (padj = 0.035), were significant for <span class="disease" id="25575156-6-187-190">CVD</span> after adjustment for multiple testing. | CTD_human |
1 | 0 | Biomarker | C1510586 | Autism Spectrum Disorders | disease | ASD | 5021 | OXTR | OXTR | CTD_human | 20,832,055 | Furthermore, amygdala volume measured with magnetic resonance imaging could be a useful intermediate phenotype to uncover the complex link between OXTR and social dysfunction in ASD. | 0.203297 | Furthermore, amygdala volume measured with magnetic resonance imaging could be a useful intermediate phenotype to uncover the complex link between <span class="gene" id="20832055-10-147-151">OXTR</span> and social dysfunction in <span class="disease" id="20832055-10-178-181">ASD</span>. | CTD_human |
null | null | Negative | MESH:D009336 | null | null | tumor necrosis factor | 21926 | null | TNF | null | 28,088,582 | Etanercept, a tumor necrosis factor (TNF)-decoy receptor, was used to study the contribution of TNF-a during LPS-mediated liver injury. | null | null | null |
1 | 0 | Therapeutic | C1458155 | Mammary Neoplasms | group | breast tumors | 6518 | SLC2A5 | Glut5 | CTD_human | 15,449,313 | The results imply an alternative way in treating breast tumor as the AS against Glut5, unlike tamoxifen, takes effect on breast tumor cells via suppressing the expression of Glut5 that they specifically possess, and regardless whether the breast tumors are estrogen dependent or not. | 0.200549 | The results imply an alternative way in treating <span class="disease" id="15449313-9-49-61">breast tumor</span> as the AS against <span class="gene" id="15449313-9-80-85">Glut5</span>, unlike tamoxifen, takes effect on <span class="disease" id="15449313-9-121-133">breast tumor</span> cells via suppressing the expression of <span class="gene" id="15449313-9-174-179">Glut5</span> that they specifically possess, and regardless whether the <span class="disease" id="15449313-9-239-252">breast tumors</span> are estrogen dependent or not. | CTD_human |
3 | 0 | Biomarker | C0020429 | Hyperalgesia | phenotype | hyperalgesia | 3569 | IL6 | IL-6 | CTD_human | 10,401,557 | The ODQ potentiated hyperalgesia induced by carrageenan, bradykinin, TNF alpha, IL-1 beta, IL-6 and IL-8. | 0.28 | The ODQ potentiated <span class="disease" id="10401557-10-20-32">hyperalgesia</span> induced by carrageenan, bradykinin, TNF alpha, IL-1 beta, <span class="gene" id="10401557-10-91-95">IL-6</span> and IL-8. | CTD_human |
null | null | Negative | MESH:D006943 | null | null | hyperglycemia | 20693 | null | SPc | null | 28,178,616 | In addition, subchronic administration of PPc has shown more significant (P<= 0.05) amelioration of hyperglycemia, weight-loss and oxidative stress at all doses compared to SPc administration. | null | null | null |
2 | 0 | Biomarker | C1868720 | Periventricular Nodular Heterotopia | disease | periventricular heterotopia | 2316 | FLNA | FLN1 | CTD_human | 11,914,408 | Familial periventricular heterotopia: missense and distal truncating mutations of the FLN1 gene. | 0.490714 | Familial <span class="disease" id="11914408-0-9-36">periventricular heterotopia</span>: missense and distal truncating mutations of the <span class="gene" id="11914408-0-86-90">FLN1</span> gene. | CTD_human;ORPHANET |
3 | 0 | Biomarker | C0036572 | Seizures | phenotype | seizures | 6750 | SST | SRIF-14 | CTD_human | 20,134,357 | SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14. | 0.200549 | SRA880 did not affect <span class="disease" id="20134357-4-22-29">seizure</span> severity and did not reverse the anticonvulsive action of <span class="gene" id="20134357-4-88-95">SRIF-14</span> (1 microM) against pilocarpine-induced <span class="disease" id="20134357-4-135-143">seizures</span>, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of <span class="gene" id="20134357-4-240-247">SRIF-14</span>. | CTD_human |
3 | 0 | Biomarker | C0001418 | Adenocarcinoma | group | adenocarcinomas | 3845 | KRAS | KRAS | CTD_human | 20,101,149 | The Kras mutational spectra of chemically induced lung tumors in different inbred mice mimics the spectra of KRAS mutations in adenocarcinomas in smokers versus nonsmokers. | 0.404746 | The Kras mutational spectra of chemically induced lung tumors in different inbred mice mimics the spectra of <span class="gene" id="20101149-0-109-113">KRAS</span> mutations in <span class="disease" id="20101149-0-127-142">adenocarcinomas</span> in smokers versus nonsmokers. | CTD_human |
1 | 0 | Biomarker | C0027627 | Neoplasm Metastasis | phenotype | metastasis | 301 | ANXA1 | Annexin A1 | CTD_human | 20,308,542 | Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. | 0.283022 | <span class="gene" id="20308542-0-0-10">Annexin A1</span> regulates TGF-beta signaling and promotes <span class="disease" id="20308542-0-53-63">metastasis</span> formation of basal-like breast cancer cells. | CTD_human |
null | null | Negative | MESH:D017827 | null | null | wild-type | 196 | null | Ahr | null | 28,113,104 | Female wild-type (WT) and Ahr-deficient (knockout; KO) mice (10-12 weeks old) were divided into four groups and fed either a control or 0.5% tryptophan diet. | null | null | null |
1 | 0 | Therapeutic | C0025149 | Medulloblastoma | disease | MB | 2100 | ESR2 | ER? | CTD_human | 21,351,254 | We next investigated the molecular mechanisms by which estrogen might influence tumor progression and show that ER?, but not ER?, is involved in modulation of MB development by estrogens. | 0.201099 | We next investigated the molecular mechanisms by which estrogen might influence tumor progression and show that <span class="gene" id="21351254-8-112-115">ERβ</span>, but not ERα, is involved in modulation of <span class="disease" id="21351254-8-159-161">MB</span> development by estrogens. | CTD_human |
null | null | Negative | MESH:D018805 | null | null | sepsis | 261727 | null | CrCl | null | 28,077,047 | Patients were excluded for the following: allergy to a cephalosporin, creatinine clearance (CrCl) < 50 mL/min, receipt of concurrent Gram-negative antimicrobial, sepsis, or solid tumor malignancy. | null | null | null |
1 | 0 | Biomarker | C0028754 | Obesity | disease | obesity | 3620 | IDO1 | IDO1 | CTD_human | 27,020,609 | Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGF?, and IDO1. | 0.2 | Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced <span class="disease" id="27020609-0-74-81">obesity</span>. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and <span class="gene" id="27020609-0-158-162">IDO1</span>. | CTD_human |
null | null | Negative | MESH:D029424 | null | null | chronic obstructive pulmonary disease | 260431 | null | COPD | null | 28,005,831 | METHODS: We determined whether complications in patients undergoing moderate sedation bronchoscopy differ in those without obstruction compared with chronic obstructive pulmonary disease (COPD). | null | null | null |
1 | 0 | Biomarker | C0037274 | Dermatologic disorders | group | skin diseases | 56547 | MMP26 | MMP-26 | CTD_human | 16,984,259 | Expression of MMP-26 was detected by immunohistochemistry in granulomatous skin diseases and actinic elastosis. | 0.200549 | Expression of <span class="gene" id="16984259-7-14-20">MMP-26</span> was detected by immunohistochemistry in granulomatous <span class="disease" id="16984259-7-75-88">skin diseases</span> and actinic elastosis. | CTD_human |
5 | 0 | Biomarker | C0011581 | Depressive disorder | disease | depression | 1269 | CNR2 | CB2-R | CTD_human | 18,286,196 | Our data demonstrate the functional expression of CB2-Rs in brain that may provide novel targets for the effects of cannabinoids in depression and substance abuse disorders beyond neuro-immunocannabinoid activity. | 0.401099 | Our data demonstrate the functional expression of <span class="gene" id="18286196-10-50-55">CB2-R</span>s in brain that may provide novel targets for the effects of cannabinoids in <span class="disease" id="18286196-10-132-142">depression</span> and substance abuse disorders beyond neuro-immunocannabinoid activity. | CTD_human;PSYGENET |
1 | 0 | Biomarker | C0034069 | Pulmonary Fibrosis | disease | pulmonary fibrosis | 1437 | CSF2 | granulocyte-macrophage colony stimulating factor | CTD_human | 17,894,541 | Increased granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) levels in BAL fluid from patients with sulfur mustard gas-induced pulmonary fibrosis. | 0.200275 | Increased granulocyte-colony stimulating factor (G-CSF) and <span class="gene" id="17894541-0-60-108">granulocyte-macrophage colony stimulating factor</span> (GM-CSF) levels in BAL fluid from patients with sulfur mustard gas-induced <span class="disease" id="17894541-0-184-202">pulmonary fibrosis</span>. | CTD_human |
null | null | Negative | MESH:D009369 | null | null | tumor | 18792 | null | urokinase plasminogen activator | null | 28,060,552 | It also significantly reduced the B19-NS1-exacerbated hepatic matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) expressions by downregulating tumor necrosis factor (TNF)-a/NF-kB (p65) signaling. | null | null | null |
null | null | Negative | MESH:D002277 | null | null | vascular invasive carcinoma | 12165 | null | BMP9 | null | 28,142,420 | BMP9 is upregulated in the RIP1-Tag2 murine model of vascular invasive carcinoma; treatment with a murine version of dalantercept (RAP-041) can inhibit tumor growth. | null | null | null |
null | null | Negative | MESH:D020521 | null | null | stroke | 723819 | null | miR-181c | null | 28,053,821 | However, the roles of miR-181c in stroke are not known. | null | null | null |
null | null | Negative | MESH:D014947 | null | null | injury to villi/crypts and villus length | 24835 | null | TNFa | null | 28,060,943 | The following end-points were analyzed: 7-day survival; biomarkers of enterocyte viability (L-lactate, I-FABP); histology (morphologic injury to villi/crypts and villus length); intestinal permeability (Ussing chamber); endotoxin translocation (Lipopolysaccharide assay); cytokines (IL-6, IL-1-b, TNFa, IFN-y IL-10, IL-13); apoptosis (cleaved caspase-3); and autophagy (LC3, p62). | null | null | null |
null | null | Negative | MESH:D011475 | null | null | overall survival | 1956 | null | epidermal growth factor receptor | null | 28,131,635 | BACKGROUND: To investigate the effect of combined epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) receptor (VEGFR) pathway inhibitors on progression-free survival (PFS) and overall survival (OS) in patients with non-small-cell lung cancer (NSCLC). | null | null | null |
1 | 1 | Biomarker | C0002736 | Amyotrophic Lateral Sclerosis | disease | amyotrophic lateral sclerosis | 1804 | DPP6 | DPP6 | CTD_human | 18,084,291 | Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. | 0.211877 | Genetic variation in <span class="gene" id="18084291-0-21-25">DPP6</span> is associated with susceptibility to <span class="disease" id="18084291-0-63-92">amyotrophic lateral sclerosis</span>. | CTD_human |
null | null | Negative | MESH:D001929 | null | null | brain edema | 83810 | null | TRPV1 | null | 28,199,737 | Then, infarct volume, brain edema, body temperature, mRNA expression of TRPV1, and serum concentrations of tumor necrosis factor-alpha (TNF-a) and IL-10 were measured. | null | null | null |
3 | 0 | Biomarker | C0023530 | Leukopenia | disease | leucopenia | 7172 | TPMT | thiopurine S-methyltransferase | CTD_human | 22,535,280 | The variant genotype thiopurine S-methyltransferase has been associated with the occurrence of leucopenia. | 0.214979 | The variant genotype <span class="gene" id="22535280-10-21-51">thiopurine S-methyltransferase</span> has been associated with the occurrence of <span class="disease" id="22535280-10-95-105">leucopenia</span>. | CTD_human |
null | null | Negative | MESH:D007153 | null | null | defines antibody deficiency | 260431 | null | COPD | null | 28,212,436 | We describe here an important observation that defines antibody deficiency as a potential risk factor for frequent COPD exacerbations. | null | null | null |
null | null | Negative | MESH:D020151 | null | null | protein kinase C | 26419 | null | c-Jun N-terminal kinase | null | 28,130,265 | The aim of the present study was to investigate whether tolerance to opioid-induced respiratory depression is mediated by protein kinase C (PKC) and/or c-Jun N-terminal kinase (JNK). | null | null | null |
null | null | Negative | MESH:D066253 | null | null | pulmonary vascular remodeling | 29560 | null | HIF-1a | null | 28,100,330 | CONCLUSIONS: In neonatal rats with HPH, HSP70 transfection can increase the expression of HSP70 in lung tissues, downregulate the expression of HIF-1a, ET-1, and iNOS, alleviate pulmonary vascular remodeling, and reduce pulmonary artery pressure; therefore, it may become a new strategy for the treatment of HPH in neonates. | null | null | null |
null | null | Negative | MESH:D050723 | null | null | fracture | 19227 | null | parathyroid hormone-related protein | null | 28,178,186 | To demonstrate whether an exogenous supply of parathyroid hormone-related protein (PTHrP) helps in bone fracture healing, closed mid-diaphyseal femur fractures were created and stabilized with intramedullary pins in eight-week-old wild-type (WT) PTHrP+/+ and PTHrP+/- mice. | null | null | null |
5 | 0 | Biomarker | C0026848 | Myopathy | group | myopathy | 10599 | SLCO1B1 | SLCO1B1 | CTD_human | 21,243,006 | Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin. | 0.214965 | Differential effect of the rs4149056 variant in <span class="gene" id="21243006-0-48-55">SLCO1B1</span> on <span class="disease" id="21243006-0-59-67">myopathy</span> associated with simvastatin and atorvastatin. | CTD_human |
20 | 0 | Biomarker | C0037769 | West Syndrome | disease | infantile spasms | 5443 | POMC | ACTH | CTD_human | 20,078,871 | Clinical profile and treatment of infantile spasms using vigabatrin and ACTH--a developing country perspective. | 0.203022 | Clinical profile and treatment of <span class="disease" id="20078871-0-34-50">infantile spasms</span> using vigabatrin and <span class="gene" id="20078871-0-72-76">ACTH</span>--a developing country perspective. | CTD_human |
null | null | Negative | MESH:D064726 | null | null | triple negative | 672;675 | null | BRCA1/2 | null | 28,021,525 | Group A: triple negative (TN); Group B: HER-2 overexpressed (HER-2+); and Group C: BRCA1/2 mutation carriers. | null | null | null |
1 | 0 | Biomarker | C0034069 | Pulmonary Fibrosis | disease | lung fibrosis | 1232 | CCR3 | CCR3 | CTD_human | 16,314,464 | Together, these data suggest that CCL11 and CCR3 are important in the pulmonary recruitment of granulocytes and play significant pathogenic roles in blm-induced lung fibrosis. | 0.200275 | Together, these data suggest that CCL11 and <span class="gene" id="16314464-10-44-48">CCR3</span> are important in the pulmonary recruitment of granulocytes and play significant pathogenic roles in blm-induced <span class="disease" id="16314464-10-161-174">lung fibrosis</span>. | CTD_human |
null | null | Negative | MESH:D000860 | null | null | hypoxia | 24185 | null | AKT | null | 28,186,348 | We found that hypoxia can increase the expansion and migration of MSCs by activating the PI3K/AKT and hypoxia-inducible factor-1a/CXC chemokine receptor-4 pathways. | null | null | null |
1 | 0 | Biomarker | C0038220 | Status Epilepticus | disease | status epilepticus | 4208 | MEF2C | MEF2C | CTD_human | 18,949,272 | Myocyte-specific enhancer binding factor 2C (MEF2C) expression in the dentate gyrus during development and after pilocarpine-induced status epilepticus: a preliminary report. | 0.2 | Myocyte-specific enhancer binding factor 2C (<span class="gene" id="18949272-0-45-50">MEF2C</span>) expression in the dentate gyrus during development and after pilocarpine-induced <span class="disease" id="18949272-0-133-151">status epilepticus</span>: a preliminary report. | CTD_human |
null | null | Negative | MESH:D009135 | null | null | VML injury | 14173 | null | basic fibroblast growth factor | null | 28,162,053 | Herein, KN hydrogels with and without the addition of skeletal muscle progenitor cells (MPCs) and/or insulin-like growth factor 1 (IGF-1) and/or basic fibroblast growth factor (bFGF) were implanted in an established murine model of surgically induced VML injury to the latissimus dorsi (LD) muscle. | null | null | null |
2 | 0 | Biomarker | C0043459 | Zellweger Syndrome | disease | Zellweger syndrome | 5194 | PEX13 | PEX13 | CTD_human | 19,449,432 | Zellweger syndrome caused by PEX13 deficiency: report of two novel mutations. | 0.400549 | <span class="disease" id="19449432-0-0-18">Zellweger syndrome</span> caused by <span class="gene" id="19449432-0-29-34">PEX13</span> deficiency: report of two novel mutations. | CTD_human;ORPHANET |
null | null | Negative | MESH:D000230 | null | null | adenocarcinoma | 285782 | null | cT3 | null | 28,133,202 | Biopsy specimens revealed mixed squamous- and adenocarcinoma: MtLtUtAeG, 13 cm, type 2, cT3, IM1-St, cN3, cM1(liver, lungs, and stomach), cStage IV b esophagealcarcinoma. | null | null | null |
null | null | Negative | MESH:D004194 | null | null | organ injury/dysfunction | 84027 | null | glycogen synthase kinase-3b | null | 28,059,970 | CONCLUSIONS: Artesunate attenuated the organ injury/dysfunction associated with HS by a mechanism that involves the activation of the Akt-endothelial nitric oxide synthase survival pathway, and the inhibition of glycogen synthase kinase-3b and nuclear factor kappa B. | null | null | null |
null | null | Negative | MESH:D010024 | null | null | osteoporosis | 286779 | null | ATP6V1H | null | 28,158,191 | We identified two generations of individuals in which short stature and osteoporosis co-segregated with a mutation in ATP6V1H. | null | null | null |
null | null | Negative | MESH:D002764 | null | null | cholecystitis | 100326838 | null | AST | null | 28,014,041 | No hospital death and PI-related morbidity were observed (elevation of AST/ALT in 1 CTR and 1 PIG, and cholecystitis in 1 CTR patients). | null | null | null |
68 | 0 | Therapeutic | C0020538 | Hypertensive disease | group | hypertension | 5443 | POMC | ACTH | CTD_human | 2,992,854 | Potentiation of ACTH hypertension in man with salt loading. | 0.203846 | Potentiation of <span class="gene" id="2992854-0-16-20">ACTH</span> <span class="disease" id="2992854-0-21-33">hypertension</span> in man with salt loading. | CTD_human |
1 | 0 | Biomarker | C0025958 | Microcephaly | disease | microcephaly | 7283 | TUBG1 | TUBG1 | CTD_human | 23,603,762 | Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. | 0.2 | Mutations in <span class="gene" id="23603762-0-13-18">TUBG1</span>, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and <span class="disease" id="23603762-0-93-105">microcephaly</span>. | CTD_human |
1 | 0 | Biomarker | C1956346 | Coronary Artery Disease | disease | coronary artery disease | 9365 | KL | KLOTHO | CTD_human | 12,669,274 | KLOTHO allele status and the risk of early-onset occult coronary artery disease. | 0.202747 | <span class="gene" id="12669274-0-0-6">KLOTHO</span> allele status and the risk of early-onset occult <span class="disease" id="12669274-0-56-79">coronary artery disease</span>. | CTD_human |
null | null | Negative | MESH:D001943 | null | null | TNBC | 53378 | null | syndecan-binding protein | null | 28,141,839 | Our previous study showed that downregulating syndecan-binding protein (SDCBP) in TNBC inhibits the proliferation of TNBC cells. | null | null | null |
null | null | Negative | MESH:D009069 | null | null | intellectual disability | 22589 | null | ATRX | null | 28,093,507 | A key example is ATRX, an X-linked gene commonly mutated in individuals with syndromic and nonsyndromic intellectual disability. | null | null | null |
null | null | Negative | MESH:D006963 | null | null | Hyperphagia | 59301 | null | ghrelin | null | 28,054,308 | Hyperphagia induced by the intracerebroventricular (icv) administration of ghrelin was significantly suppressed for at least 2 h by pretreatment with icv administration of DORA. | null | null | null |
null | null | Negative | MESH:D050197 | null | null | atherosclerosis | 11600 | null | Ang-1 | null | 28,069,704 | We investigated the role of Ang-1 in atherosclerosis-prone apolipoprotein-E (Apo-E) knockout mouse. | null | null | null |
21 | 87 | Biomarker | C0033847 | Pseudoxanthoma Elasticum | disease | pseudoxanthoma elasticum | 368 | ABCC6 | MRP6 | CTD_human | 11,880,368 | Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). | 0.77791 | Loss of ATP-dependent transport activity in <span class="disease" id="11880368-0-44-68">pseudoxanthoma elasticum</span>-associated mutants of human <span class="gene" id="11880368-0-97-102">ABCC6</span> (<span class="gene" id="11880368-0-104-108">MRP6</span>). | CTD_human;ORPHANET;UNIPROT |
1 | 0 | Biomarker | C0040953 | Trichotillomania | disease | trichotillomania | 3218 | HOXB8 | Hoxb8 | CTD_human | 11,779,477 | The aberrant behavior observed in Hoxb8 mutants is not unlike that of humans suffering from the OC-spectrum disorder, trichotillomania. | 0.280275 | The aberrant behavior observed in <span class="gene" id="11779477-8-34-39">Hoxb8</span> mutants is not unlike that of humans suffering from the OC-spectrum disorder, <span class="disease" id="11779477-8-118-134">trichotillomania</span>. | CTD_human |
2 | 0 | Biomarker | C0242422 | Parkinsonian Disorders | group | parkinsonism | 7054 | TH | tyrosine hydroxylase | CTD_human | 8,817,341 | Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene. | 0.403846 | Recessively inherited L-DOPA-responsive <span class="disease" id="8817341-0-40-52">parkinsonism</span> in infancy caused by a point mutation (L205P) in the <span class="gene" id="8817341-0-106-126">tyrosine hydroxylase</span> gene. | CTD_human;HPO |
null | null | Negative | MESH:D014808 | null | null | VD | 18036 | null | IkB | null | 28,055,298 | Finally, the ability of VD to deactivate NF-kB signaling, via p65 and IkB phosphorylation inhibition in murine adipocyte, was observed and could constitute a driving molecular mechanism. | null | null | null |
1 | 0 | Biomarker | C0036341 | Schizophrenia | disease | SZ | 3123 | HLA-DRB1 | HLA-DRB1 | CTD_human | 16,223,876 | Implementing this systematic approach, we: (i) discovered 177 putative SZ risk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological processes and 12 molecular functions that may be particularly disrupted in the illness; (iii) identified 123 putative SZ biomarkers in blood, 6 of which (BTG1, GSK3A, HLA-DRB1, HNRPA3, SELENBP1, and SFRS1) had corresponding differential expression in brain; (iv) verified the differential expression of the strongest candidate SZ biomarker (SELENBP1) in blood; and (v) demonstrated neuronal and glial expression of SELENBP1 protein in brain. | 0.211067 | Implementing this systematic approach, we: (i) discovered 177 putative <span class="disease" id="16223876-4-71-73">SZ</span> risk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological processes and 12 molecular functions that may be particularly disrupted in the illness; (iii) identified 123 putative SZ biomarkers in blood, 6 of which (BTG1, GSK3A, <span class="gene" id="16223876-4-337-345">HLA-DRB1</span>, HNRPA3, SELENBP1, and SFRS1) had corresponding differential expression in brain; (iv) verified the differential expression of the strongest candidate SZ biomarker (SELENBP1) in blood; and (v) demonstrated neuronal and glial expression of SELENBP1 protein in brain. | CTD_human |
1 | 0 | Biomarker | C0023267 | Fibroid Tumor | disease | leiomyomas | 2099 | ESR1 | ER-alpha | CTD_human | 18,701,604 | Further analysis of the DNA methylation status by bisulfite restriction mapping among 11 paired samples of myometrium and leiomyoma indicated that CpG sites in the distal region of ER-alpha promoter are hypomethylated in leiomyomas of nine patients. | 0.243463 | Further analysis of the DNA methylation status by bisulfite restriction mapping among 11 paired samples of myometrium and <span class="disease" id="18701604-7-122-131">leiomyoma</span> indicated that CpG sites in the distal region of <span class="gene" id="18701604-7-181-189">ER-alpha</span> promoter are hypomethylated in <span class="disease" id="18701604-7-221-231">leiomyomas</span> of nine patients. | CTD_human |
null | null | Negative | MESH:D009369 | null | null | tumor | 20296 | null | monocyte chemotactic protein 1 | null | 28,074,537 | Moreover, the TG mice displayed a pro-inflammatory profile, with significant increases in monocyte chemotactic protein 1, tumor necrosis factor alpha, and interleukin-10. | null | null | null |
1 | 0 | Biomarker | C1832200 | Peroxisome biogenesis disorders | group | peroxisome-biogenesis disorders | 55670 | PEX26 | PEX26 | CTD_human | 12,851,857 | Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation. | 0.201099 | Mutations in novel peroxin gene <span class="gene" id="12851857-0-32-37">PEX26</span> that cause <span class="disease" id="12851857-0-49-80">peroxisome-biogenesis disorders</span> of complementation group 8 provide a genotype-phenotype correlation. | CTD_human |
1 | 0 | Biomarker | C0152427 | Polydactyly | disease | polydactyly | 60529 | ALX4 | Alx4 | CTD_human | 9,847,249 | First, mutation of Cart1 exacerbates Alx4-dependent polydactyly in a manner that is dependent on gene dosage. | 0.2 | First, mutation of Cart1 exacerbates <span class="gene" id="9847249-8-37-41">Alx4</span>-dependent <span class="disease" id="9847249-8-52-63">polydactyly</span> in a manner that is dependent on gene dosage. | CTD_human |
null | null | Negative | MESH:D000592 | null | null | HA | 12505 | null | CD44 | null | 28,208,014 | In particular, HPN treatment dramatically inhibited tumor growth, likely because of the specific tumor-targeting affinity of HA for CD44-overexpressed cancer cells. | null | null | null |
7 | 0 | Biomarker | C0033578 | Prostatic Neoplasms | group | prostate tumor | 6648 | SOD2 | SOD2 | CTD_human | 19,074,884 | In a low-selenium population, SOD2-Ala16+ men homozygous for SEPP1-Ala234 are at an increased risk of prostate cancer/aggressive prostate cancer especially if ever-smokers, because they are likely to produce more mitochondrial H(2)O(2) that they cannot remove, thereby promoting prostate tumor cell proliferation and migration. | 0.219354 | In a low-selenium population, <span class="gene" id="19074884-13-30-34">SOD2</span>-Ala16+ men homozygous for SEPP1-Ala234 are at an increased risk of prostate cancer/aggressive prostate cancer especially if ever-smokers, because they are likely to produce more mitochondrial H(2)O(2) that they cannot remove, thereby promoting <span class="disease" id="19074884-13-279-293">prostate tumor</span> cell proliferation and migration. | CTD_human |
null | null | Negative | MESH:D001943 | null | null | BC | 672;675 | null | BRCA1/2 | null | 28,023,740 | We also analyzed 24 BC patients with a family history (BRCAPRO scores > 80%; Manchester score >40) without BRCA1/2 mutations. | null | null | null |
11 | 0 | Biomarker | C0020429 | Hyperalgesia | phenotype | hyperalgesia | 7124 | TNF | tumor necrosis factor alpha | CTD_human | 16,472,913 | Neither of these inhibitors, however, affected tumor necrosis factor alpha, prostaglandin E2 or epinephrine hyperalgesia. | 0.280549 | Neither of these inhibitors, however, affected <span class="gene" id="16472913-5-47-74">tumor necrosis factor alpha</span>, prostaglandin E2 or epinephrine <span class="disease" id="16472913-5-108-120">hyperalgesia</span>. | CTD_human |
1 | 0 | Biomarker | C0026769 | Multiple Sclerosis | disease | MS | 348 | APOE | APOE | CTD_human | 15,048,896 | Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4. | 0.316713 | Accelerated evolution of brain atrophy and "black holes" in <span class="disease" id="15048896-0-60-62">MS</span> patients with <span class="gene" id="15048896-0-77-81">APOE</span>-epsilon 4. | CTD_human |
null | null | Negative | MESH:D002545 | null | null | HIE | 362119 | null | C5a | null | 28,002,390 | RESULTS: We found that HT increased systemic expression of C3a and decreased expression of C5a after HIE. | null | null | null |
null | null | Negative | MESH:D002908 | null | null | chronic disorder | 3630 | null | insulin | null | 28,198,081 | Diabetes mellitus is a chronic disorder caused by relative or absolute insulin deficiency and characterized by chronic hyperglycaemia. | null | null | null |
69 | 0 | Therapeutic | C0020538 | Hypertensive disease | group | hypertension | 183 | AGT | angiotensin II | CTD_human | 17,989,111 | Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension. | 0.52 | Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during <span class="gene" id="17989111-0-107-121">angiotensin II</span>-induced <span class="disease" id="17989111-0-130-142">hypertension</span>. | CTD_human |
null | null | Negative | MESH:C536293 | null | null | JS | 9851 | null | KIAA0753 | null | 28,125,082 | RESULTS: We identified the causative gene in 94% of the families; 126 (27 novel) unique potentially pathogenic variants were found in 20 genes, including KIAA0753 and CELSR2, which had not previously been associated with JS. | null | null | null |
1 | 0 | Biomarker | C0035412 | Rhabdomyosarcoma | disease | rhabdomyosarcoma | 5395 | PMS2 | PMS2 | CTD_human | 19,293,170 | In family 2, immunohistochemistry analysis showed isolated loss of PMS2 expression in all tumours in the affected patients, including rhabdomyosarcoma itself and the surrounding normal tissue. | 0.400275 | In family 2, immunohistochemistry analysis showed isolated loss of <span class="gene" id="19293170-7-67-71">PMS2</span> expression in all tumours in the affected patients, including <span class="disease" id="19293170-7-134-150">rhabdomyosarcoma</span> itself and the surrounding normal tissue. | CTD_human;HPO |
2 | 1 | Biomarker | C0026691 | Mucocutaneous Lymph Node Syndrome | disease | Kawasaki disease | 2212 | FCGR2A | FCGR2A | CTD_human | 22,446,962 | We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease. | 0.205429 | We also replicated the association of a functional SNP of <span class="gene" id="22446962-4-58-64">FCGR2A</span> (rs1801274, P = 1.6 × 10(-6)) identified in a recently reported GWAS of <span class="disease" id="22446962-4-137-153">Kawasaki disease</span>. | CTD_human |
null | null | Negative | MESH:D009369 | null | null | inha/Tag adrenal tumors | 18019 | null | Nfatc2 | null | 28,131,743 | Besides earlier reported Gata4 and Lhcgr, we found up-regulated Esr1, Prlr-rs1, and down-regulated Grb10, Mmp24, Sgcd, Rerg, Gnas, Nfatc2, Gnrhr, Igf2 in inha/Tag adrenal tumors. | null | null | null |
3 | 0 | Biomarker | C0027627 | Neoplasm Metastasis | phenotype | metastasis | 7040 | TGFB1 | TGF-?1 | CTD_human | 23,146,760 | Resveratrol inhibits TGF-?1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis. | 0.231797 | Resveratrol inhibits <span class="gene" id="23146760-0-21-27">TGF-β1</span>-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and <span class="disease" id="23146760-0-113-123">metastasis</span>. | CTD_human |
1 | 0 | Biomarker | C0014544 | Epilepsy | disease | epilepsy | 22953 | P2RX2 | P2X2 | CTD_human | 12,941,474 | Here we show that, in the seizure-sensitive (SS) gerbil hippocampus, a recognized genetic epilepsy model, the expressions of both P2X2 and P2X4 receptors are markedly decreased as compared with that in the seizure-resistant (SR) gerbil. | 0.2 | Here we show that, in the seizure-sensitive (SS) gerbil hippocampus, a recognized genetic <span class="disease" id="12941474-4-90-98">epilepsy</span> model, the expressions of both <span class="gene" id="12941474-4-130-134">P2X2</span> and P2X4 receptors are markedly decreased as compared with that in the seizure-resistant (SR) gerbil. | CTD_human |
1 | 0 | Biomarker | C0003615 | Appendicitis | disease | appendicitis | 3586 | IL10 | IL-10 | CTD_human | 16,367,942 | The increased IFN-gamma may support the notion of gangrenous appendicitis as an uncontrolled Th1 mediated inflammatory response and increased IL-10 may speculatively indicate the involvement of cytotoxic cells in the progression to perforation. | 0.2 | The increased IFN-gamma may support the notion of gangrenous <span class="disease" id="16367942-10-61-73">appendicitis</span> as an uncontrolled Th1 mediated inflammatory response and increased <span class="gene" id="16367942-10-142-147">IL-10</span> may speculatively indicate the involvement of cytotoxic cells in the progression to perforation. | CTD_human |
null | null | Negative | MESH:D008107 | null | null | liver dysfunction | 12364 | null | Casp12 | null | 28,098,217 | However, a subgroup of (pre)pubertal knockout mice (runts) exhibits a pronounced male prevalent liver dysfunction characterized by downregulated amino acid metabolism and elevated Casp12. | null | null | null |
1 | 0 | Biomarker | C0023492 | Leukemia, T-Cell | disease | T-cell leukemia | 4005 | LMO2 | Rhom-2 | CTD_human | 2,034,676 | Therefore, chromosome bands 11p15 (rhombotin) and 11p13 (Rhom-2) are consistent sites of chromosome translocation in T-cell leukemia, with the 11p15 target more rarely involved. | 0.203022 | Therefore, chromosome bands 11p15 (rhombotin) and 11p13 (<span class="gene" id="2034676-10-57-63">Rhom-2</span>) are consistent sites of chromosome translocation in <span class="disease" id="2034676-10-117-132">T-cell leukemia</span>, with the 11p15 target more rarely involved. | CTD_human |
null | null | Negative | MESH:D001855 | null | null | bone marrow toxicity | 16551 | null | Eg5 | null | 28,022,538 | RESULTS: The bone marrow toxicity and DNA damage seen with other Eg5 inhibitors were not evident with ARQ 621. | null | null | null |
1 | 0 | Biomarker | C0018801 | Heart failure | disease | heart failure | 156 | GRK2 | GRK2 | CTD_human | 26,670,611 | Conversely, the dual-specific GRK2 and ERK cascade inhibitor, RKIP (Raf kinase inhibitor protein), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg-regulated genes. | 0.208176 | Conversely, the dual-specific <span class="gene" id="26670611-8-30-34">GRK2</span> and ERK cascade inhibitor, RKIP (Raf kinase inhibitor protein), triggered dysfunctional cardiomyocyte energetics and the expression of <span class="disease" id="26670611-8-170-183">heart failure</span>-promoting Pparg-regulated genes. | CTD_human |
6 | 2 | Biomarker | C2239176 | Liver carcinoma | disease | hepatocellular carcinoma | 7157 | TP53 | p53 | CTD_human | 17,191,126 | Different levels of p53 induced either apoptosis or cell cycle arrest in a doxycycline-regulated hepatocellular carcinoma cell line in vitro. | 0.672301 | Different levels of <span class="gene" id="17191126-0-20-23">p53</span> induced either apoptosis or cell cycle arrest in a doxycycline-regulated <span class="disease" id="17191126-0-97-121">hepatocellular carcinoma</span> cell line in vitro. | CTD_human;HPO |
null | null | Negative | MESH:D009362 | null | null | metastasis | 17381 | null | MMP12 | null | 28,098,914 | miR-647 also reduced the expression levels of genes associated with proliferation and metastasis in tumors, including ANK2, FAK, MMP2, MMP12, CD44 and SNAIL1. | null | null | null |
14 | 0 | Biomarker | C0020538 | Hypertensive disease | group | hypertension | 1906 | EDN1 | endothelin-1 | CTD_human | 11,847,185 | No study has yet determined the impact of this polymorphism on vascular reactivity, although a functional role for endothelin-1 in the pathophysiology of hypertension has been clarified. | 0.339563 | No study has yet determined the impact of this polymorphism on vascular reactivity, although a functional role for <span class="gene" id="11847185-2-115-127">endothelin-1</span> in the pathophysiology of <span class="disease" id="11847185-2-154-166">hypertension</span> has been clarified. | CTD_human |
null | null | Negative | MESH:D024801 | null | null | tauopathy | 5563 | null | AMPK | null | 28,202,389 | The introduction of miR-101b mimics or small interfering RNAs (siRNAs) against AMPK blocked HDAC2-induced tauopathy and dendritic impairments in vitro. | null | null | null |
14 | 181 | Biomarker | C0175695 | Sotos' syndrome | disease | Sotos syndrome | 64324 | NSD1 | NSD1 | CTD_human | 16,188,863 | Auxological data in patients clinically suspected of Sotos syndrome with NSD1 gene alterations. | 0.627551 | Auxological data in patients clinically suspected of <span class="disease" id="16188863-0-53-67">Sotos syndrome</span> with <span class="gene" id="16188863-0-73-77">NSD1</span> gene alterations. | CTD_human;ORPHANET;UNIPROT |
2 | 0 | Biomarker | C1832200 | Peroxisome biogenesis disorders | group | peroxisome biogenesis disorders | 5190 | PEX6 | peroxisome assembly factor-2 | CTD_human | 10,408,779 | Genomic structure and identification of 11 novel mutations of the PEX6 (peroxisome assembly factor-2) gene in patients with peroxisome biogenesis disorders. | 0.201648 | Genomic structure and identification of 11 novel mutations of the <span class="gene" id="10408779-0-66-70">PEX6</span> (<span class="gene" id="10408779-0-72-100">peroxisome assembly factor-2</span>) gene in patients with <span class="disease" id="10408779-0-124-155">peroxisome biogenesis disorders</span>. | CTD_human |
1 | 0 | Biomarker | C2239176 | Liver carcinoma | disease | hepatocellular carcinoma | 4313 | MMP2 | MMP-2 | CTD_human | 20,084,675 | Our results reveal that BA exerts its anti-metastatic effect against DEN-induced hepatocellular carcinoma by inhibiting the activities and expressions of MMP-2 and MMP-9. | 0.221609 | Our results reveal that BA exerts its anti-metastatic effect against DEN-induced <span class="disease" id="20084675-9-81-105">hepatocellular carcinoma</span> by inhibiting the activities and expressions of <span class="gene" id="20084675-9-154-159">MMP-2</span> and MMP-9. | CTD_human |
1 | 0 | Biomarker | C0011882 | Diabetic Neuropathies | group | diabetic neuropathy | 4313 | MMP2 | MMP-2 | CTD_human | 20,213,226 | The results of the present study suggest that MMP-2 and MMP-9 inhibition in the presence of COX inhibitor prevents the development of experimental diabetic neuropathy in rats and can be a potential approach for the treatment. | 0.2 | The results of the present study suggest that <span class="gene" id="20213226-5-46-51">MMP-2</span> and MMP-9 inhibition in the presence of COX inhibitor prevents the development of experimental <span class="disease" id="20213226-5-147-166">diabetic neuropathy</span> in rats and can be a potential approach for the treatment. | CTD_human |
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