text
stringlengths 174
850
| embeddings_A
sequence |
|---|---|
Wnt signaling has diverse actions in cardiovascular development and disease processes. Secreted frizzled-related protein 5 (Sfrp5) has been shown to function as an extracellular inhibitor of non-canonical Wnt signaling that is expressed at relatively high levels in white adipose tissue. The aim of this study was to investigate the role of Sfrp5 in the heart under ischemic stress. Sfrp5 KO and WT mice were subjected to ischemia/reperfusion (I/R). Although Sfrp5-KO mice exhibited no detectable phenotype when compared with WT control at baseline, they displayed larger infarct | [
-0.03484524,
-0.010268828,
0.00016171465,
-0.03177066,
-0.0103160255,
0.0043623974,
-0.027293641,
0.0055490774,
-0.0068672365,
-0.0113071725,
0.019647645,
0.005869346,
0.0030762658,
0.01898688,
-0.010423905,
-0.0014546944,
0.027482431,
0.0124062,
0.00045216893,
0.0036240937,
-0.0099519305,
0.017921565,
-0.023180716,
-0.006604279,
-0.011529675,
0.01065315,
-0.0032128014,
-0.03487221,
-0.0006118819,
-0.04889661,
0.011415053,
0.002693629,
-0.01755747,
-0.0068604937,
-0.012399457,
-0.010046326,
0.0008562975,
-0.0229245,
0.007814557,
-0.03511494,
0.010214888,
-0.00868434,
0.0042106914,
0.01790808,
-0.013768185,
-0.0073560677,
-0.0014353098,
-0.01432107,
0.016465185,
0.01677534,
0.015736995,
-0.0043893675,
-0.019998256,
-0.0035094714,
-0.010120492,
-0.008428125,
0.02931639,
0.02057811,
0.01237923,
-0.01782717,
0.022937985,
0.018784605,
-0.021832215,
0.013208558,
-0.001038345,
0.020969175,
-0.015089715,
0.0046995226,
0.00760554,
0.008515778,
0.03719163,
0.028021831,
-0.02446179,
0.0014420522,
0.021279331,
-0.0022283962,
-0.024043756,
-0.0031049212,
-0.01289166,
-0.0093248775,
0.026767725,
-0.013464773,
-0.016141545,
0.030260341,
0.027361065,
0.008104485,
0.0054816524,
0.021872671,
-0.03063792,
-0.00043404844,
0.019243095,
0.017543985,
0.0013771557,
0.0075178877,
-0.01014072,
-0.022155855,
0.0019637533,
0.01596624,
0.014900926,
-0.0326337,
-0.004763576,
0.00035061,
-0.02389542,
-0.018353086,
-0.01925658,
-0.00067593565,
-0.015197596,
-0.0077808453,
0.03751527,
-0.01442895,
-0.03430584,
0.038998622,
-0.0014192963,
-0.023962846,
0.023463901,
-0.01432107,
0.012338775,
0.0070324275,
-0.008798962,
-0.008724795,
0.021265846,
0.028669111,
0.02473149,
-0.01030254,
0.022776166,
0.0045242175,
0.009756397,
-0.007969636,
-0.01534593,
-0.006078364,
0.001793505,
0.00714705,
-0.00644583,
-0.009581093,
-0.011179065,
0.0076931925,
-0.014091825,
0.0055996464,
-0.02969397,
-0.05224089,
-0.0023801026,
0.0057985503,
-0.03204036,
-0.024124665,
-0.021616455,
-0.0077741025,
0.017247315,
-0.001308045,
0.0023211057,
-0.0053737727,
-0.017854141,
-0.015683055,
0.017355196,
-0.0096552605,
-0.008219108,
0.022236766,
-0.017840656,
0.013208558,
-0.011583615,
-0.0100530675,
-0.00291276,
-0.0084011555,
0.009372075,
0.00695826,
0.014820015,
0.012750068,
0.00015634172,
0.0045613013,
0.008165168,
-0.000912766,
-0.027522886,
0.023140261,
-0.03794679,
0.030071551,
0.02694303,
-0.011576872,
0.0075650853,
0.0019030707,
-0.01974204,
-0.018191265,
-0.04007742,
0.003443732,
0.008023575,
0.013033253,
-0.01518411,
-0.020564625,
0.019000364,
-0.009918218,
0.01205559,
-0.0229245,
0.008232593,
0.02394936,
-0.008906842,
-0.00792918,
-0.624841,
-0.010720575,
0.013943491,
-0.00080530735,
0.013646821,
0.028480321,
0.010531785,
0.0018676725,
-0.025823776,
0.03530373,
-0.014105311,
0.026970001,
-0.0008057288,
-0.02327511,
-0.024232546,
-0.027293641,
-0.02119842,
-0.019485826,
0.018582331,
0.0054715388,
-0.007908952,
0.0031453762,
-0.006105334,
0.024556186,
0.014846985,
0.014536831,
0.026444085,
-0.025446195,
-0.026686816,
-0.009857535,
-0.018272175,
0.0213063,
-0.011994908,
0.0025284376,
0.057230342,
0.0044635353,
-0.00012368274,
0.018029446,
0.01634382,
0.04919328,
-0.019782495,
-0.0037724287,
0.014846985,
-0.008893358,
-0.02230419,
0.022857076,
-0.0105452705,
0.024057241,
-0.0041837213,
-0.0055221077,
-0.0032397714,
-0.022857076,
-0.0312852,
0.009486698,
0.0064222314,
-0.01434804,
0.0087315375,
-0.01548078,
0.016397761,
0.027495915,
0.012446655,
0.04177653,
0.0012161784,
-0.0009026522,
0.024124665,
0.013464773,
-0.023423446,
-0.00075684563,
0.021994036,
-0.004534331,
0.027482431,
0.028021831,
0.009614805,
0.03177066,
0.012500595,
0.03034125,
-0.008933812,
0.0050063063,
0.00083733426,
0.0034403608,
0.005919915,
0.009216998,
-0.02982882,
-0.011880285,
0.0124601405,
0.017247315,
-0.01658655,
0.016546095,
0.0023059351,
0.008542747,
0.0032195437,
-0.0049557374,
-0.012069075,
-0.040913492,
-0.02424603,
0.015008805,
0.015790936,
0.012123015,
0.0014715507,
-0.015548205,
-0.0077875876,
0.01523805,
0.004220805,
-0.017867625,
-0.0040690987,
-0.0033409088,
-0.044365652,
-0.00730887,
0.024326941,
-0.04107531,
-0.0047804327,
-0.005660329,
0.00903495,
-0.0029869275,
-0.0058727176,
-0.01852839,
0.04296321,
-0.01515714,
0.01521108,
-0.027495915,
0.02297844,
-0.0067425002,
0.019809466,
-0.0036240937,
0.02955912,
-0.0077066775,
0.00277791,
0.013383863,
-0.0030324394,
-0.01755747,
0.02289753,
-0.02322117,
0.020456746,
-0.020861296,
-0.00043910532,
-0.0012128073,
0.00388368,
0.0221154,
0.02540574,
-0.026295751,
-0.02996367,
-0.00868434,
0.013680533,
-0.014253645,
-0.007322355,
-0.0032431425,
0.0142941,
-0.004922025,
0.020267956,
0.0012119644,
-0.02098266,
-0.025365286,
0.0049658515,
0.00738978,
0.003681405,
-0.013100678,
0.018299146,
-0.01717989,
-0.018865515,
-0.012574763,
0.008320245,
0.012237637,
-0.020227501,
-0.0066076503,
0.003543184,
-0.01561563,
-0.007855013,
-0.012089303,
0.0028841044,
-0.021818731,
-0.009473213,
-0.020632051,
-0.003961219,
0.016788825,
0.0049152826,
0.03767709,
0.0050366474,
-0.0051445276,
-0.01761141,
-0.0075516,
0.005431084,
-0.04067076,
-0.026875606,
0.0017446219,
0.02659242,
0.010376708,
0.013849095,
0.025715895,
-0.0092911655,
0.01796202,
-0.01882506,
0.01836657,
-0.01620897,
0.012500595,
-0.0049759652,
-0.017988991,
0.02459664,
0.0029852418,
-0.009776625,
0.03015246,
0.01955325,
-0.02133327,
0.0029245594,
-0.0081381975,
0.0070391702,
-0.026754241,
0.014145765,
-0.018865515,
0.01583139,
-0.009284423,
-0.004932139,
0.03414402,
-0.0015979726,
-0.013795155,
-0.009419273,
0.00036072376,
-0.010970048,
-0.005424341,
0.0013704131,
-0.004652325,
-0.012412943,
-0.010707091,
-0.002144115,
0.00076653797,
-0.01205559,
0.012709613,
0.0026363176,
0.0121634705,
0.0095878355,
-0.03266067,
-0.013903035,
0.011003761,
0.0057850652,
-0.012621961,
0.0004589114,
-0.00838767,
0.0037083752,
-0.03390129,
0.02146812,
0.008832675,
0.02020053,
-0.00081794953,
0.021184936,
-0.009257453,
-0.0006139889,
-0.018299146,
0.020362351,
0.03355068,
-0.011913998,
0.03791982,
0.008718053,
0.0399156,
-0.0038634525,
0.01788111,
0.01459077,
-0.01734171,
0.01237923,
-0.0012153357,
0.02950518,
0.022911016,
0.03538464,
0.012170212,
0.015197596,
-0.02297844,
0.01998477,
0.0150357755,
-0.00226548,
-0.01329621,
-0.00534006,
0.003934249,
-0.012898402,
-0.0042106914,
-0.0074100075,
-0.0302064,
0.009823822,
0.014145765,
0.01534593,
0.007612283,
0.006442459,
0.0009945187,
0.02343693,
-0.02982882,
0.024273,
0.014469406,
-0.012932115,
-0.0035162137,
-0.0134850005,
0.000903495,
-0.02281662,
0.0151032,
-0.00046733953,
0.0035937526,
0.00021870984,
-0.0040522427,
-0.0034690164,
-0.010929593,
0.012143243,
-0.02667333,
0.03268764,
-0.0150357755,
-0.0005035805,
0.015939271,
-0.019297035,
-0.03816255,
0.053508483,
0.016303366,
0.0055861613,
0.029343361,
0.0113071725,
-0.0019890375,
0.00068984204,
-0.01175892,
0.0096889725,
-0.011927483,
0.0016325278,
0.00180699,
0.0012355632,
-0.014981835,
0.03341583,
0.026700301,
-0.01777323,
-0.034710392,
-0.0110577,
-0.04644234,
0.015736995,
0.025688926,
0.0047130077,
0.012750068,
-0.0032246006,
-0.0022570519,
-0.017274285,
-0.012905145,
0.01742262,
-0.02079387,
0.0023463902,
-0.00078634406,
0.007403265,
-0.01014072,
0.00008933813,
0.0013417575,
0.0068571228,
-0.028938811,
0.0027256557,
-0.03120429,
0.00474672,
-0.016869735,
-0.011212777,
0.042369872,
0.025513621,
0.015804421,
0.006894206,
0.04463535,
-0.00041339954,
-0.023598751,
0.0069515174,
0.015130171,
-0.00040244297,
-0.026498025,
-0.011961196,
-0.01998477,
0.008212365,
0.008326988,
0.0069110626,
0.02899275,
0.02839941,
0.032148242,
0.022182826,
0.00846858,
-0.0280488,
-0.006128933,
0.00798312,
0.0119005125,
0.012615218,
-0.0153729,
0.021346755,
-0.02621484,
-0.019189155,
-0.014307586,
0.01631685,
-0.015291991,
0.012797265,
-0.008461838,
-0.0028588201,
-0.02837244,
-0.0137142455,
-0.0137547,
0.0048444862,
-0.0147391055,
0.01750353,
0.006631249,
-0.002386845,
-0.031123381,
-0.00043404844,
-0.00811797,
0.01882506,
-0.02030841,
-0.03228309,
0.021238875,
0.0015499322,
0.024178606,
-0.0025419225,
-0.005269264,
0.00057606236,
0.00717402,
0.006307609,
-0.01345803,
-0.006678446,
-0.030260341,
0.004787175,
-0.01912173,
-0.01604715,
-0.02872305,
-0.0039679613,
-0.01418622,
0.0059671127,
-0.000059260256,
0.021724336,
-0.013983945,
0.0057243826,
0.013640078,
0.018703695,
0.009729427,
0.02486634,
0.00871131,
0.017085494,
-0.007295385,
-0.013397348,
-0.012500595,
-0.0006847852,
-0.0115364175,
-0.0039039075,
-0.0066649616,
-0.013660305,
-0.01415925,
0.015440325,
-0.006010939,
0.006037909,
-0.00871131,
0.0258912,
0.04358352,
-0.0016148288,
0.024421336,
0.02152206,
-0.012844463,
-0.005616503,
-0.00480066,
0.026848635,
-0.00760554,
-0.011671267,
0.009668745,
-0.004756834,
-0.016276395,
-0.025769835,
0.009850793,
-0.00709311,
0.03177066,
0.0034066483,
-0.024340425,
-0.02618787,
0.018973395,
-0.011340885,
-0.0078010727,
-0.017813684,
0.018649755,
-0.02969397,
-0.0009785054,
0.0075583425,
-0.02138721,
0.028345471,
-0.03311916,
-0.007672965,
0.006307609,
0.0040623564,
-0.012129758,
-0.0009768197,
0.0075178877,
-0.020996146,
-0.007747133,
-0.028075771,
-0.058147322,
-0.007598798,
-0.01548078,
0.013849095,
0.03473736,
-0.007025685,
0.0049557374,
0.008529263,
0.016330335,
-0.00946647,
0.0021154594,
-0.0069043203,
-0.00722796,
-0.029073661,
0.05739216,
0.0011698238,
0.00034386752,
0.01566957,
-0.008475322,
0.01372773,
0.008785478,
-0.01397046,
-0.012642188,
0.01769232,
-0.020942206,
0.0031335768,
0.0030256968,
-0.012278093,
-0.006300866,
-0.027388036,
0.009257453,
0.029667001,
-0.005704155,
-0.00396459,
-0.0075853127,
0.014833501,
-0.03778497,
0.024313455,
-0.009405788,
0.008758508,
-0.0020261214,
-0.01825869,
0.011907255,
-0.0109430775,
0.01604715,
-0.0045208465,
-0.009668745,
0.003924135,
-0.01545381,
-0.01405137,
0.0013468144,
-0.023234656,
-0.013437803,
0.0072751576,
-0.006938033,
-0.017260801,
-0.019485826,
-0.01696413,
-0.04843812,
0.0020328637,
-0.005120929,
-0.03632859,
0.0102823125,
0.012015135,
-0.013195072,
0.008987753,
-0.025055131,
0.03034125,
0.0011976366,
0.0391065,
0.02605302,
0.00914283,
-0.021292815,
-0.0065705664,
-0.0037589439,
0.0072751576,
0.04061682,
-0.006196358,
-0.008104485,
-0.02038932,
-0.013505228,
0.029073661,
-0.03252582,
-0.025095586,
0.014995321,
-0.0021272588,
0.0059030587,
-0.007133565,
0.005936771,
-0.03894468,
0.022830106,
-0.007888725,
-0.029262451,
-0.0009085519,
-0.03387432,
-0.0280488,
0.02384148,
0.01445592,
0.0058423765,
-0.008340472,
-0.01623594,
-0.00655371,
-0.01736868,
0.010862168,
0.011010502,
0.01027557,
0.027226215,
0.0008756822,
0.013302953,
0.03034125,
0.021454636,
0.005997454,
-0.0046556965,
-0.0070526553,
0.04663113,
0.025122555,
-0.00013685168,
0.01620897,
-0.016923675,
-0.0053535453,
0.01475259,
-0.023072835,
-0.02928942,
-0.038540132,
-0.008596688,
0.03284946,
0.0066076503,
-0.004392739,
-0.002526752,
-0.03549252,
-0.0040758415,
-0.025109071,
-0.023962846,
0.0072481874,
-0.02915457,
0.0023767313,
-0.01971507,
0.016573066,
-0.01534593,
0.020079166,
0.007726905,
0.02179176,
0.0399156,
-0.021481605,
0.02179176,
-0.00714705,
0.021265846,
-0.02613393,
0.01637079,
-0.01936446,
-0.021697365,
0.01494138,
-0.019836435,
-0.0291276,
0.0012305062,
0.00080067187,
0.027428491,
0.005468168,
0.0027576825,
0.01809687,
-0.01696413,
-0.0023716744,
0.0044331937,
0.02416512,
0.010410421,
-0.010450875,
-0.008259563,
0.024340425,
-0.0053906287,
-0.0011512819,
-0.0011571816,
0.0046556965,
0.02918154,
0.0032178583,
-0.020402806,
-0.008886615,
0.0042713736,
-0.027172275,
-0.008825933,
-0.028021831,
-0.013195072,
-0.024273,
0.0021727707,
0.0058457474,
-0.020267956,
-0.0144424355,
-0.0046556965,
-0.01299954,
0.0041196677,
-0.02044326,
-0.0053299465,
-0.02618787,
-0.01561563,
-0.01677534,
0.0007404108,
-0.01310742,
0.032795522,
0.011994908,
-0.01928355,
-0.015008805,
0.02543271,
-0.043286853,
-0.0358701,
-0.02489331,
0.0010788001,
0.0054108566,
0.008677598,
0.011138611,
-0.002405387,
0.0073493253,
0.0011116697,
0.0062368126,
-0.017274285,
-0.0008305917,
-0.012763552,
0.01108467,
0.014820015,
-0.025284376,
-0.04379928,
0.03608586,
-0.002697,
0.0020075794,
0.03314613,
-0.02602605,
0.01974204,
-0.04021227,
0.02222328,
0.02192661,
0.0031352625,
0.033604622,
-0.02901972,
0.014712135,
0.016977616,
0.0041162963,
-0.016532611,
0.008509035,
0.0039207637,
0.009594577,
-0.02006568,
-0.016330335,
-0.022964956,
-0.00046733953,
-0.0065469677,
0.00984405,
-0.008670855,
-0.014307586,
0.024637096,
0.016074121,
-0.019890375,
-0.019216126,
-0.0089001,
-0.0018761007,
0.0115701305,
0.016411245,
0.01782717,
-0.023827996,
0.00671553,
-0.0005254936,
-0.0240033,
-0.0071200803,
0.0029279308,
0.0028605056,
-0.011522933,
0.020564625,
-0.02268177,
0.006037909,
-0.017975505,
0.0145638,
-0.0018289032,
-0.02413815,
-0.0053906287,
-0.0048074024,
0.0039039075,
-0.0361398,
0.008542747,
-0.03373947,
-0.01944537,
-0.000130952,
-0.013822125,
0.011792633,
0.038270433,
0.20432472,
-0.00050990155,
0.013930005,
0.0033661933,
-0.0013063594,
0.011913998,
-0.004318571,
-0.0047298637,
-0.0074100075,
0.014199705,
-0.0024744975,
0.014280615,
-0.00501642,
-0.0052793776,
0.021414181,
-0.004085955,
-0.0027610539,
-0.0046455828,
-0.002990299,
-0.013080451,
0.014995321,
-0.016384276,
0.0043725115,
-0.0042477753,
0.012487111,
0.033065222,
-0.03328098,
-0.018353086,
0.027576825,
0.02011962,
-0.014995321,
0.004150009,
0.01372773,
0.007592055,
-0.0031571756,
-0.0014285672,
-0.025581045,
0.01459077,
0.018757636,
-0.0019570107,
-0.010902623,
-0.01626291,
0.013208558,
0.007430235,
-0.0044972477,
0.00393762,
-0.0047972887,
-0.018771121,
-0.00331731,
0.028615171,
-0.03921438,
0.0253518,
0.026241811,
0.02864214,
-0.007079625,
-0.0129456,
0.0020058937,
0.007403265,
-0.0025924912,
0.016761856,
-0.03195945,
-0.009500182,
-0.016802311,
0.03090762,
-0.03676011,
0.056637,
-0.013383863,
0.0018154181,
0.020834325,
0.0066447337,
-0.004541074,
-0.01769232,
-0.011779148,
-0.0013779985,
-0.01893294,
-0.008596688,
0.02146812,
0.012143243,
0.0121365,
0.027886981,
0.026659846,
-0.02203449,
-0.027415005,
0.011367856,
0.0032431425,
-0.03115035,
0.014995321,
0.007457205,
-0.006135675,
-0.010403678,
0.0035195851,
-0.00062368123,
-0.013774928,
-0.023126775,
0.023477385,
-0.03282249,
-0.006108705,
0.00380277,
0.000028181543,
-0.015494266,
-0.0052894913,
0.06866562,
-0.0058288914,
-0.0015895444,
-0.012952343,
-0.0067559853,
0.010457618,
0.013876066,
-0.007814557,
-0.0024626981,
0.011233006,
-0.025378771,
-0.011671267,
-0.01815081,
0.0039275065,
0.019404916,
0.0115364175,
-0.010127235,
0.02192661,
-0.024070725,
-0.025985595,
0.0010172747,
0.017395651,
0.018353086,
-0.0065705664,
0.017854141,
0.0036038663,
0.008913585,
0.0064121177,
-0.0116038425,
0.0093585905,
-0.03144702,
-0.026848635,
0.01356591,
0.008798962,
-0.0037791713,
0.0021390582,
0.009527152,
0.01515714,
0.02853426,
-0.0062671537,
-0.0096889725,
0.027388036,
0.024448305,
0.0030442388,
0.008859646,
0.02961306,
0.012709613,
0.009918218,
-0.0010341309,
-0.014145765,
0.0033105675,
0.0046624388,
-0.018946426,
0.0250821,
-0.011138611,
-0.006064879,
-0.030449132,
-0.0025705781,
-0.012284835,
-0.031689752,
0.03284946,
0.002289079,
-0.018177781,
-0.0076662228,
-0.013181588,
-0.17012677,
0.025769835,
0.020780385,
-0.03417099,
0.03813558,
0.021967065,
0.0037286025,
-0.0010105323,
-0.010686862,
0.030071551,
0.03395523,
-0.00949344,
0.0039207637,
0.0021053457,
-0.01895991,
0.007989863,
0.0010872282,
0.026578935,
-0.012075818,
0.00798312,
0.02284359,
-0.0142941,
0.01744959,
-0.0223851,
0.006294124,
-0.0027441976,
0.0031116637,
-0.019081276,
-0.0057547237,
-0.0124062,
-0.0012743325,
0.011388083,
0.02354481,
-0.0034369894,
-0.0052422937,
-0.006631249,
-0.014658195,
-0.018029446,
-0.012871433,
0.04032015,
0.03330795,
0.033604622,
-0.012089303,
-0.01472562,
-0.037083752,
0.01734171,
-0.013073708,
-0.006530111,
0.021211905,
-0.0031993163,
0.019769011,
-0.008792221,
-0.012015135,
0.007753875,
0.024798915,
0.01243317,
-0.0032701127,
0.0076257675,
0.0025385513,
-0.021643426,
-0.015629115,
0.01464471,
0.02767122,
0.01359288,
0.02408421,
-0.025203465,
0.0065874225,
0.017584441,
-0.02869608,
0.01194771,
-0.02486634,
-0.0052726353,
-0.0054277126,
-0.017382165,
0.012696127,
0.02303238,
0.011893771,
-0.00033101463,
-0.0022351388,
0.01734171,
-0.01386258,
0.002548665,
-0.01243317,
-0.024852855,
0.0048478576,
0.011961196,
0.007726905,
-0.01734171,
0.014793045,
-0.0128242355,
0.016923675,
-0.028345471,
0.015143655,
-0.005714269,
0.027468946,
-0.00089253846,
-0.018380055,
-0.01397046,
-0.012237637,
0.006405375,
0.023018895,
-0.01494138,
0.009715943,
-0.01885203,
0.018299146,
0.011253233,
-0.010983532,
0.01723383,
0.048653882,
-0.014900926,
0.0060749925,
-0.00946647,
-0.00784827,
0.0052928627,
0.00042857017,
0.009365332,
0.005781694,
-0.0058592325,
0.0033729356,
-0.052483622,
0.07702632,
0.0078213,
-0.0027189131,
0.02734758,
-0.0026902575,
-0.023598751,
-0.12870084,
-0.03983469,
0.013822125,
0.0253518,
-0.02634969,
0.0078213,
0.013788412,
0.03600495,
-0.0030105263,
0.03818952,
-0.0207669,
-0.024637096,
-0.0010155891,
-0.0035600401,
0.0038263688,
-0.0010088466,
0.018838545,
-0.008664113,
-0.03349674,
0.04406898,
-0.025567561,
-0.02899275,
-0.0010830141,
-0.0062806387,
-0.00787524,
0.0013468144,
-0.03120429,
0.01200165,
0.006604279,
0.010531785,
0.0310155,
0.005936771,
0.025041645,
-0.009918218,
-0.02548665,
-0.0028015089,
-0.008569717,
-0.03106944,
0.03096156,
-0.02429997,
0.015521235,
0.010565498,
0.01734171,
-0.010801485,
-0.0149683505,
0.024650581,
-0.02394936,
0.007807815,
0.01415925,
-0.028021831,
-0.03627465,
-0.02899275,
-0.011233006,
-0.0022098543,
0.05466819,
-0.025392255,
0.023922391,
0.01839354,
-0.012183698,
-0.006017681,
0.016411245,
0.00029034892,
-0.0167214,
-0.0030948075,
0.01744959,
-0.022277221,
-0.02133327,
-0.02475846,
0.022803135,
-0.0017024813,
-0.00428823,
0.0054513114,
-0.00738978,
0.0030155831,
-0.017139435,
0.008326988,
-0.0112060355,
-0.0007117552,
-0.0015271762,
-0.0391065,
-0.01531896,
-0.017570956,
0.03106944,
-0.021616455,
0.009662002,
-0.0019114988,
0.01297257,
-0.01523805,
0.01958022,
-0.015710026,
-0.005394,
0.04293624,
-0.0010366593,
-0.0045242175,
-0.0062031,
0.022991925,
-0.004905169,
-0.0030762658,
-0.006702045,
0.0016889963,
-0.0061323037,
-0.013316438,
-0.05466819,
0.01340409,
0.012500595,
0.01599321,
0.0010594153,
-0.012042105,
0.0062368126,
0.01796202,
0.01264893,
-0.023329051,
-0.02931639,
0.01939143,
-0.0038499676,
-0.0042916015,
-0.012345518,
-0.009783368,
0.03697587,
0.00531309,
0.028615171,
0.02411118,
0.0073965224,
0.0008672541,
-0.0027846526,
0.0015887016,
0.02203449,
-0.009594577,
-0.035168882,
0.015413355,
0.014064855,
-0.0018457595,
-0.0014336241,
-0.035977982,
-0.026565451,
0.0024424708,
0.002437414,
-0.005417599,
0.0017496787,
0.02842638,
0.011388083,
0.0005233866,
-0.01397046,
-0.02618787,
0.0037656864,
-0.00372186,
0.010929593,
0.025823776,
-0.03220218,
0.006108705,
0.00358701,
-0.020092651,
0.023504356,
0.01548078,
-0.0075178877,
-0.022735711,
-0.039268322,
0.01610109,
0.0051748687,
0.0017631638,
-0.0167214,
-0.01464471,
0.003978075,
0.00035798462,
-0.00307458,
0.003254942,
0.0070998524,
-0.012992797,
-0.0052894913,
-0.003150433,
0.0077808453,
-0.01531896,
-0.040913492,
-0.00560976,
0.013808641,
0.02529786,
0.0028824187,
0.00860343,
-0.02891184,
-0.004102811,
-0.026686816,
0.029343361,
0.030071551,
-0.00493551,
-0.02915457,
0.0137142455,
0.029990641,
-0.0034201331,
-0.0027323982,
0.01631685,
-0.014577285,
0.02041629,
-0.00033459658,
0.017112466,
-0.007989863,
0.021508574,
0.009756397,
0.031878542,
-0.0054007424,
0.01882506,
0.014401981,
0.023342535,
-0.012844463,
-0.0049557374,
0.0076392526,
0.0029464725,
-0.01521108,
0.011023988,
-0.018083386,
-0.013849095,
-0.018595815,
-0.011158838,
0.009594577,
-0.004409595,
-0.01019466,
0.0010063181,
-0.011684753,
0.009419273,
0.008724795,
-0.009729427,
-0.013437803,
0.0183396,
0.006135675,
-0.00976314,
-0.01399743,
-0.000020332853,
-0.0004188778,
0.015116685,
0.027752131,
-0.03109641,
0.03530373,
-0.01939143,
0.0415338,
0.010632923,
-0.02052417,
-0.004082584,
0.026147416,
0.014496375,
-0.0073560677,
0.014927896,
-0.01777323,
0.091104664,
0.0025284376,
-0.014900926,
-0.02060508,
-0.017260801,
-0.00046944656,
-0.01626291,
0.016195485,
-0.0020648907,
-0.03419796,
0.010740803,
-0.023693146,
0.03859407,
-0.021130996,
-0.030395191,
0.016896706,
-0.0019974657,
0.011597101,
-0.01388955,
-0.019566735,
0.013983945,
-0.004237661,
0.020092651,
0.009911475,
-0.0385671,
-0.025567561,
0.040643793,
-0.017867625,
0.007881982,
0.0009633347,
-0.0134850005,
0.016977616,
-0.030988531,
-0.008771992,
0.028345471,
0.01089588,
-0.012817493,
-0.012257866,
0.0043152003,
0.011738692,
-0.0017766488,
0.010619437,
-0.013983945,
-0.019769011,
0.008502292,
-0.01111164,
0.013013025,
0.00865737,
-0.037083752
] |
BACKGROUND Technological advancements in neuroimaging and the increased use of these diagnostic modalities are responsible for the discovery of incidentally identified anomalies within the CNS. In addition to the identification of unanticipated brain MRI abnormalities suggestive of demyelinating disease in patients undergoing neuroimaging for a medical reason other than evaluation for multiple sclerosis (MS), asymptomatic spinal cord lesions are periodically identified. OBJECTIVE To determine if asymptomatic spinal cord lesions are associated with clinical progression in subjects with radiologically isolated syndrome (RIS). METHODS A retrospective review of RIS cases at the University of California, San Francisco Multiple Sclerosis Center was performed. The presence | [
-0.0039930847,
-0.0011040708,
0.034784205,
-0.046770282,
-0.023330536,
0.009692616,
-0.006621012,
-0.022989247,
-0.010293284,
-0.013405843,
0.021187238,
0.02667517,
-0.014607182,
0.015699307,
0.0047234436,
0.0063889353,
0.04614231,
0.016818736,
0.01912585,
-0.00885987,
-0.024217887,
0.014320498,
-0.026702473,
0.007767744,
-0.0016262435,
-0.008484452,
0.013781262,
-0.029951548,
-0.016886994,
-0.012839302,
0.020258931,
-0.023180367,
-0.0033651122,
-0.026552306,
-0.0052695065,
0.00004175461,
0.011788132,
-0.0058121565,
-0.00072481314,
-0.014457014,
0.0041193618,
-0.0066107735,
-0.017228283,
-0.027917463,
-0.0028139302,
0.019863036,
-0.0057097697,
-0.017910862,
-0.010238678,
0.017255586,
0.040517863,
0.008190943,
-0.032436132,
0.014020164,
-0.017050812,
-0.028586391,
0.016054248,
0.022620654,
0.0007452905,
-0.0521217,
0.002472641,
-0.011637964,
-0.022306668,
0.0036859242,
0.0021535354,
0.0047951145,
-0.0053991964,
0.013405843,
-0.00062669243,
-0.012013383,
0.02050466,
0.017910862,
-0.0054264995,
-0.010300111,
0.033692077,
-0.015617398,
-0.007822351,
-0.02249779,
0.016996207,
0.0027695626,
0.03543948,
-0.022989247,
-0.010757438,
0.01051171,
0.0115355775,
-0.0036176664,
-0.009624358,
0.033227924,
-0.015849475,
-0.007856479,
-0.005798505,
0.033036802,
0.004842895,
0.0014837552,
-0.0008762602,
0.014361453,
0.003245661,
0.028914029,
-0.0059691495,
-0.017446708,
-0.015931385,
0.012054337,
-0.034183536,
-0.0030187038,
-0.007132946,
-0.0028548848,
0.012627703,
0.020586569,
0.037842155,
-0.014429711,
0.009521971,
0.0077609182,
-0.0043241354,
-0.0059418464,
0.017187329,
0.0024606958,
0.026729777,
0.022293016,
-0.0061944006,
-0.013910951,
0.007979344,
-0.007091991,
0.007508364,
-0.024122326,
0.03169895,
0.010812044,
-0.04423109,
0.007378674,
-0.004501606,
-0.016559357,
-0.026443094,
-0.024982376,
0.019344276,
0.009590229,
0.023125762,
0.002450457,
0.010388846,
0.006791657,
-0.031316705,
-0.045459732,
0.029023241,
0.03333714,
-0.023781037,
-0.009583403,
0.008784786,
0.004716618,
0.021828862,
0.01112603,
0.0020921032,
-0.010648225,
-0.025173498,
-0.028531784,
0.0013327347,
-0.004733682,
-0.013835868,
-0.002564789,
0.012668658,
0.027576175,
-0.005931608,
-0.028367965,
-0.003317332,
-0.0015383614,
-0.02225206,
0.002801985,
-0.0014393876,
0.017733391,
-0.010211376,
-0.011057773,
-0.013112335,
-0.01311916,
-0.0044708895,
0.020600222,
-0.017214632,
-0.0052968096,
0.0008271999,
-0.017160024,
-0.007924737,
0.023726432,
-0.029023241,
-0.025132542,
0.0062899613,
0.013617442,
0.03762373,
-0.0029265557,
0.003131329,
0.019617308,
0.036012847,
-0.023071155,
-0.0027695626,
-0.028832119,
-0.008668748,
0.021678695,
-0.014497968,
-0.014293196,
-0.60765874,
-0.028477177,
0.014839258,
-0.01746036,
0.029296272,
0.023412446,
-0.0019675328,
-0.0004411164,
0.0114946235,
0.040872805,
-0.016968904,
0.023644522,
0.012948516,
0.0038906978,
-0.0074401065,
-0.016231718,
-0.008231898,
0.010907605,
0.022129197,
-0.011146508,
-0.015371669,
0.024190584,
-0.009651661,
0.015644701,
0.0014521859,
0.018115636,
0.008764309,
-0.00599304,
-0.004402632,
0.021173587,
-0.029924244,
0.013719829,
-0.018020075,
0.006501561,
0.04960981,
-0.0010673823,
-0.0021177,
0.033937808,
-0.007317242,
0.013323934,
-0.01685969,
-0.014811955,
0.020422751,
-0.0027354336,
-0.0116720935,
0.032381527,
0.016982555,
0.0035494086,
0.006330916,
-0.034593083,
0.03290029,
0.00046458005,
-0.028832119,
-0.00054137013,
0.014102073,
-0.019876689,
0.014102073,
-0.019794779,
0.016627613,
0.0028565913,
-0.018429622,
0.007719964,
-0.0108052185,
-0.01666857,
-0.018893775,
0.03500263,
-0.006235355,
-0.036941152,
0.026634216,
-0.020436402,
0.034456566,
0.03284568,
-0.0026774143,
0.0010571436,
0.021651393,
0.036968455,
0.010197724,
0.006941824,
-0.0004952961,
-0.0074264547,
-0.024545526,
-0.011603836,
-0.029815031,
0.0034265444,
-0.0053718933,
-0.024545526,
-0.014921168,
0.017255586,
-0.00017907022,
0.0054947576,
-0.0045527993,
0.016805084,
-0.00960388,
-0.04846308,
-0.003131329,
0.019753823,
-0.007992995,
0.02050466,
0.020040506,
0.0033651122,
-0.0100543825,
0.006272897,
0.021405663,
0.001929991,
0.013740307,
0.0008020298,
-0.017419405,
-0.002389025,
0.038770463,
-0.015617398,
-0.0014863148,
-0.01415668,
-0.0003415026,
-0.011194289,
0.025569392,
-0.027931115,
-0.00083786517,
-0.006119317,
-0.02528271,
-0.01255262,
0.0077950475,
0.0015400678,
0.0031296227,
-0.013788087,
0.000116998235,
0.0054094354,
0.0160679,
-0.0012713026,
0.007132946,
-0.023726432,
-0.016709523,
-0.029815031,
0.014211286,
-0.015153244,
0.0043138964,
-0.003597189,
0.018921077,
-0.014702742,
-0.009412758,
-0.0382244,
-0.03440196,
-0.03587633,
0.0016663449,
-0.0077609182,
-0.013869996,
-0.0047609857,
-0.024381706,
0.00038331051,
0.010825696,
-0.0051841843,
-0.010798393,
-0.004815592,
-0.015057683,
0.016777782,
0.018661698,
-0.020313539,
-0.01883917,
-0.02675708,
0.0029828683,
-0.016777782,
-0.022743518,
0.010846173,
-0.007064688,
0.019781128,
-0.01972652,
-0.040627077,
-0.024340753,
0.011474146,
-0.007453758,
-0.024873164,
-0.0038565688,
0.0063548065,
0.008327459,
0.014825607,
0.00547428,
0.0047370954,
0.004679076,
-0.01912585,
-0.013528707,
-0.007173901,
-0.0036825114,
0.010969037,
0.022484139,
-0.028286057,
0.03587633,
0.0018753846,
0.036094755,
-0.010880303,
0.0014590117,
0.013364889,
-0.025842424,
0.047753196,
-0.019740172,
0.0038019626,
-0.002515302,
0.014784652,
-0.006365045,
-0.0052387905,
-0.015317063,
0.011624313,
0.027617129,
-0.013337585,
0.03423814,
0.0045118444,
0.027371401,
-0.026784383,
0.027767297,
-0.02667517,
0.007576622,
0.0052251387,
-0.006375284,
-0.009242114,
0.0182385,
-0.01771974,
-0.019876689,
0.012149898,
0.008423019,
0.008607316,
-0.0016526934,
0.009242114,
-0.0035425827,
0.0022968769,
0.016450144,
0.010020253,
0.0160679,
0.028122237,
0.00012841009,
0.017706089,
0.009180682,
-0.024026766,
-0.006402587,
0.03440196,
0.016654918,
0.027016459,
0.011426365,
0.027071066,
-0.009242114,
0.00041957252,
0.024722995,
0.00017885692,
-0.004303658,
0.011303501,
-0.009965647,
0.014224937,
0.027958417,
0.0008195209,
0.05362337,
-0.0004807913,
-0.0009948582,
0.0356033,
-0.013931429,
-0.023644522,
-0.0138973,
0.018716304,
0.008306981,
-0.0018412557,
0.011822261,
0.0011910996,
0.042265266,
0.029350879,
0.046606466,
-0.019316973,
0.022647956,
-0.00047225904,
-0.0059828013,
0.0041876193,
0.005156881,
0.008388891,
-0.0015537195,
-0.00477805,
-0.027671736,
-0.029842336,
-0.00803395,
-0.028968634,
0.016122505,
0.016450144,
-0.0025135956,
0.025432877,
0.04559625,
0.021924423,
-0.014224937,
-0.044804458,
0.015016728,
0.0136857005,
-0.017132722,
-0.0014897278,
0.0031432742,
0.0041637295,
-0.0044435863,
-0.01554914,
0.031589735,
-0.0076653576,
-0.032217707,
0.009187507,
-0.0017474011,
-0.006784831,
0.02615641,
0.007324068,
0.0029538588,
0.0058258083,
-0.0040954715,
-0.005672228,
-0.02197903,
-0.0036552083,
0.022156501,
0.012948516,
-0.014183982,
-0.016627613,
-0.0036483824,
-0.01407477,
-0.00005471294,
-0.022784473,
-0.009515145,
0.016040597,
0.00094878423,
0.015726611,
0.011112379,
0.006330916,
0.00041786607,
0.013412669,
-0.008156814,
-0.049227566,
-0.012484362,
-0.008723354,
0.029432788,
0.03579442,
-0.002163774,
0.010566317,
0.0100748595,
-0.012948516,
-0.01072331,
-0.029296272,
0.026279274,
-0.0034043605,
-0.0029521524,
0.01198608,
0.0029197298,
0.034729596,
-0.0011023644,
0.02353531,
0.026879944,
-0.014825607,
0.006337742,
-0.0035767118,
0.0010230147,
-0.010286459,
0.012852955,
0.036285877,
0.014211286,
-0.025064286,
0.014702742,
0.022006333,
-0.022839079,
-0.015945036,
-0.027944766,
0.03901619,
-0.01520785,
0.010272807,
-0.011235244,
-0.012825651,
0.023589915,
0.0028258753,
0.009214811,
-0.0060374076,
0.028449874,
0.018170241,
0.023275929,
0.0024146216,
-0.0027013046,
-0.00032657117,
-0.019931294,
0.0069588884,
0.009999776,
-0.0117267,
0.03197198,
-0.023262277,
0.022006333,
-0.004016975,
0.038770463,
0.0001838696,
-0.01702351,
-0.007801873,
-0.014634484,
0.032272317,
0.0026501112,
-0.013009948,
-0.005689292,
-0.002552844,
-0.038279004,
-0.023658173,
-0.015194199,
0.018020075,
-0.029869638,
0.00086644816,
0.010491232,
0.0054981704,
-0.031316705,
0.016259022,
0.030716036,
0.005126165,
0.009740396,
-0.016805084,
0.010184072,
0.03093446,
-0.0061261426,
-0.00015848622,
0.007733615,
-0.022566047,
0.025555741,
0.021214541,
-0.0074947127,
-0.017064463,
-0.028559087,
0.020436402,
0.014880213,
-0.0050203656,
0.011255721,
0.007071514,
0.022047287,
0.01720098,
0.0085936645,
0.013535533,
-0.015139593,
-0.018443273,
0.0064128255,
-0.030716036,
-0.014511621,
-0.03658621,
-0.0036722727,
-0.016914297,
-0.003958956,
-0.0045357347,
0.0058496986,
-0.019671915,
0.0015016729,
-0.01394508,
0.01875726,
-0.015590095,
0.023685476,
0.013194243,
0.008402542,
0.0069281724,
0.035494085,
-0.009801828,
-0.012928038,
-0.011713048,
0.017132722,
-0.018893775,
-0.015276108,
0.022129197,
0.0054947576,
-0.025746863,
-0.03978068,
-0.025405575,
-0.0012056044,
0.063234076,
0.0053991964,
-0.020804996,
-0.02789016,
0.0005174799,
0.014620833,
-0.000676606,
-0.004682489,
-0.0091465525,
0.0026023309,
0.037378002,
-0.023221323,
0.0055937315,
0.043411996,
-0.04076359,
-0.011521926,
-0.002232032,
0.0004948695,
0.018784562,
-0.017187329,
0.01072331,
-0.01780165,
-0.0013105508,
-0.00545039,
-0.01737845,
0.023835644,
-0.0182385,
0.032709166,
0.005822395,
0.027944766,
0.023316884,
0.0026808274,
0.03057952,
-0.003532344,
0.020531964,
-0.007897434,
0.0014026989,
-0.017610528,
0.0057575502,
-0.0005831781,
-0.00079221773,
0.019480793,
-0.033500955,
0.0002723915,
0.0356033,
0.0025238344,
-0.026975505,
0.006330916,
-0.05777345,
-0.022607002,
0.001051171,
0.014716394,
0.014798303,
-0.041773807,
0.0076517058,
0.03169895,
-0.0055834926,
-0.0054026092,
-0.023644522,
0.032463435,
0.015699307,
0.010675529,
0.013992861,
0.015221502,
0.005317287,
-0.0047302693,
-0.007747267,
-0.0151259415,
0.026634216,
0.006528864,
-0.007917912,
0.05244934,
0.00942641,
0.015603746,
0.009460539,
-0.006658554,
-0.008163639,
-0.0073991516,
-0.016040597,
-0.012928038,
-0.027385052,
-0.022374926,
-0.014579878,
0.02180156,
0.01650475,
-0.010347891,
0.019985901,
-0.035821725,
-0.012593575,
0.024286145,
-0.0086346185,
0.00410571,
-0.013003122,
0.02659326,
0.009904215,
-0.036395088,
-0.03057952,
-0.009132901,
-0.0005157734,
-0.009446887,
0.033146016,
0.016122505,
-0.015685655,
-0.009187507,
0.010402498,
-0.002595505,
-0.005921369,
-0.049992055,
0.0035289312,
0.00681896,
-0.0048872624,
-0.016054248,
-0.020832298,
-0.040627077,
0.027016459,
-0.02354896,
-0.004999888,
-0.01754227,
-0.023234975,
0.0043104836,
0.0225797,
-0.046278827,
0.022074591,
-0.025528438,
-0.0040852325,
-0.008818915,
-0.007992995,
-0.019740172,
-0.006532277,
0.0042831805,
0.021214541,
-0.009317198,
0.00030716034,
-0.0031432742,
0.03336444,
0.0052114874,
0.0014615713,
-0.028695604,
0.03137131,
-0.005730247,
-0.010757438,
-0.0064264773,
-0.011706223,
0.0020306713,
-0.008457148,
-0.0043685026,
-0.01695525,
-0.011569707,
0.0067063347,
0.055452682,
0.019849384,
-0.0138631705,
0.02068213,
-0.02353531,
-0.013044076,
-0.013364889,
-0.008129511,
-0.01198608,
-0.021624088,
-0.0012533849,
0.012102118,
0.017815301,
0.017214632,
0.017856255,
-0.0020955163,
0.0020886904,
0.013255676,
-0.008893998,
0.009999776,
0.010525362,
-0.00048719047,
-0.0044845412,
0.025937986,
-0.0020818647,
-0.046770282,
-0.0034060671,
-0.003921414,
-0.030443003,
-0.011624313,
0.017787997,
-0.0062933746,
-0.0027473788,
-0.024914118,
0.024026766,
0.014730046,
-0.014880213,
0.01582217,
-0.044258393,
0.033146016,
-0.012764219,
0.006272897,
-0.00011923794,
-0.009085121,
-0.012095292,
0.005675641,
0.014402408,
-0.0055869054,
-0.026484048,
-0.022593351,
-0.030279186,
0.014047467,
-0.021610437,
0.005600557,
0.004747334,
-0.01747401,
-0.026879944,
0.0046961405,
0.026948202,
-0.00327979,
0.0018020074,
-0.012081641,
-0.00860049,
0.016613962,
-0.02016337,
-0.015863126,
0.019467141,
-0.017910862,
-0.03292759,
-0.013235198,
-0.027835554,
0.034893416,
0.02120089,
0.010798393,
-0.0043548513,
-0.0028412333,
-0.055916835,
-0.007979344,
-0.01668222,
0.010825696,
0.04245639,
0.043575816,
0.004532322,
-0.0034487282,
-0.008286504,
0.008607316,
0.013460449,
0.0023821993,
0.019835733,
0.026415791,
0.021992682,
0.0013344411,
-0.019084897,
0.0041944454,
0.013358062,
0.00013118307,
0.007010082,
0.02363087,
-0.007167075,
-0.0021569482,
-0.01216355,
0.006914521,
-0.014566227,
-0.005535712,
-0.009692616,
-0.034702294,
0.003761008,
0.006658554,
0.025856076,
0.023671824,
0.002675708,
0.0100748595,
0.019576354,
-0.014497968,
-0.031562433,
0.01695525,
0.005245616,
-0.015699307,
0.010102163,
-0.0045732763,
0.006177336,
0.0010767677,
-0.014183982,
-0.005433325,
-0.021091677,
-0.005443564,
-0.009958821,
-0.0054264995,
0.008655096,
-0.022484139,
0.013105509,
-0.001192806,
0.019999553,
-0.017009858,
-0.0069554755,
-0.01710542,
0.006399174,
-0.020886904,
0.016709523,
-0.01195195,
-0.032354224,
-0.03292759,
0.003088668,
-0.021569483,
0.0025443116,
0.0011236949,
0.0018258977,
-0.04933678,
0.009924692,
-0.0011706223,
-0.008443497,
0.0018907427,
0.0032268902,
-0.027016459,
-0.052831583,
0.0030187038,
0.17517696,
-0.0002903092,
-0.004170555,
-0.015672004,
-0.047998924,
0.012825651,
0.012607226,
-0.009071469,
-0.015835823,
0.03363747,
0.030361095,
-0.018415969,
-0.0041807937,
0.002801985,
0.019972248,
0.018347712,
-0.016927948,
-0.03483881,
-0.0042934194,
-0.01903029,
-0.001268743,
-0.0072694616,
-0.0059384336,
-0.008327459,
0.018088331,
0.021528527,
-0.00808173,
0.012136247,
0.03598554,
0.015371669,
-0.025924334,
0.006911108,
-0.0044743023,
0.0006629544,
-0.006419651,
-0.0076585314,
-0.015412624,
0.01072331,
-0.007303591,
0.020395448,
-0.0055937315,
-0.008382065,
-0.011166985,
0.014962122,
0.00232418,
0.018948382,
0.009262592,
-0.018279454,
0.008320632,
0.020791342,
-0.037296094,
-0.0026995982,
0.022811776,
-0.0011603836,
-0.0015750501,
-0.005928195,
0.026006244,
0.025337316,
-0.0005878708,
0.0052831583,
-0.020545615,
0.00042042573,
-0.018866472,
0.04403997,
-0.0021159935,
0.029350879,
0.02614276,
0.015672004,
-0.012627703,
0.0066073607,
0.022647956,
-0.015494534,
-0.02267526,
-0.008709703,
-0.0026705887,
-0.01307138,
0.03781485,
-0.0004918832,
0.014962122,
0.003689337,
-0.0015741969,
0.001754227,
-0.021255497,
0.012702787,
-0.008893998,
-0.015699307,
0.0016680514,
0.023671824,
0.01928967,
-0.002610863,
-0.003249074,
-0.019740172,
0.008347936,
-0.0013753958,
-0.016968904,
0.0011126031,
0.002836114,
-0.019153155,
-0.015617398,
0.0016723175,
-0.04977363,
0.090154976,
0.02120089,
-0.006180749,
-0.012921212,
0.009692616,
-0.022129197,
0.0067984825,
0.0047575724,
-0.015890429,
0.014866562,
-0.00573366,
0.008907651,
0.009105599,
-0.0061944006,
0.019617308,
0.0023480703,
-0.03336444,
-0.0016083258,
0.01877091,
0.013317108,
-0.021760605,
-0.011330804,
0.014102073,
-0.018907426,
-0.01381539,
0.012689136,
-0.0008335991,
-0.00668927,
-0.017160024,
-0.003107439,
-0.018811865,
0.0029640975,
0.010047557,
0.0003969621,
-0.010484407,
-0.0016799965,
0.0018037139,
-0.020518312,
-0.006661967,
0.004863372,
-0.002006781,
0.026019895,
0.0056415116,
0.024217887,
0.007194378,
0.011262546,
0.020641176,
-0.030388398,
-0.008702877,
-0.04038135,
-0.024968725,
0.012805174,
-0.009460539,
0.02414963,
-0.019098548,
-0.015358018,
-0.044012666,
-0.02571956,
0.020040506,
-0.027480613,
0.025501136,
0.027685387,
0.010928083,
0.0056517506,
-0.0030562456,
-0.17179137,
0.012040686,
0.013528707,
-0.042865936,
0.026920898,
0.009644835,
0.017351147,
-0.023576263,
-0.019166807,
-0.0024675215,
0.01832041,
-0.005962324,
-0.023603566,
-0.018347712,
0.007603925,
0.0077950475,
-0.0057234215,
0.05952085,
0.015644701,
0.022129197,
-0.0070988173,
-0.043248177,
0.022429531,
-0.018743608,
-0.007815525,
0.013371714,
-0.026388487,
0.031726252,
-0.013631094,
-0.011166985,
0.004231987,
-0.0239039,
0.02180156,
-0.010095337,
0.01877091,
0.0027576175,
-0.013501404,
-0.016354583,
-0.010573142,
0.016805084,
0.0022917576,
0.027985722,
0.021596786,
-0.0072694616,
-0.0061227297,
0.019084897,
0.015317063,
-0.047998924,
0.0024436312,
-0.005255855,
0.0024709345,
-0.0347569,
0.005788266,
0.010880303,
-0.003859982,
0.022647956,
0.0005191863,
0.017678784,
0.020422751,
-0.0140611185,
0.006631251,
-0.020272583,
0.020136068,
0.008061253,
-0.009030514,
-0.030879855,
0.020873252,
0.0063684583,
-0.021241846,
0.0058087436,
-0.0012149898,
0.010880303,
-0.029405484,
-0.027985722,
0.038279004,
0.0012235221,
0.02353531,
0.03344635,
-0.014224937,
0.0042217486,
-0.0051739453,
0.0038156142,
-0.010361543,
-0.005249029,
0.002499944,
0.006815547,
0.029105151,
0.0115151005,
0.019098548,
-0.0014615713,
0.0048565464,
-0.046115007,
0.020627525,
-0.008498103,
0.006634664,
0.04794432,
-0.010928083,
0.010457104,
-0.011562881,
0.0066449023,
-0.0106414,
0.011542403,
-0.024354404,
0.015808519,
0.012320543,
-0.018443273,
-0.015740262,
0.0124229295,
-0.0024982376,
-0.01503038,
-0.0045937537,
0.017979119,
0.017842604,
0.04065438,
-0.0017149786,
0.007719964,
-0.015003077,
-0.0017525204,
-0.0024555763,
-0.010225027,
0.06143207,
-0.00877796,
-0.004487954,
-0.02197903,
0.0057097697,
0.011453669,
-0.12362863,
-0.027262188,
0.008907651,
0.009706267,
0.009521971,
0.017187329,
-0.009283069,
0.029268969,
-0.013869996,
0.036067452,
-0.029815031,
-0.035412177,
-0.00059085706,
-0.011992905,
-0.0064128255,
-0.028204147,
-0.0098769115,
-0.006808721,
-0.030634126,
0.027207581,
0.006733638,
-0.018101983,
-0.0035835374,
-0.011085076,
-0.006474258,
-0.010914431,
-0.0066449023,
0.007330894,
0.012204505,
-0.013173766,
0.0011689158,
-0.0035425827,
0.01068918,
-0.0066414895,
-0.005535712,
0.01433415,
-0.005088623,
-0.025432877,
0.039753377,
-0.0019402296,
0.016272673,
0.031671647,
0.027658084,
0.032463435,
-0.0038633947,
-0.018811865,
-0.031398613,
0.021009767,
0.013917777,
-0.013617442,
-0.005501583,
-0.015740262,
-0.011440017,
0.010559491,
0.01676413,
0.001089566,
0.009358152,
0.016805084,
-0.031125583,
-0.019494444,
-0.001926578,
-0.005829221,
-0.013869996,
0.02831336,
-0.012054337,
-0.0064128255,
-0.017651482,
-0.024449965,
-0.007289939,
-0.031152885,
-0.013262502,
-0.021965379,
-0.014170331,
-0.031835463,
-0.02423154,
0.032190405,
0.0038941107,
-0.022593351,
0.013781262,
-0.019685566,
-0.011071424,
-0.020340841,
0.03118019,
-0.012907561,
0.035057236,
0.023330536,
0.011392237,
-0.017296541,
-0.014497968,
-0.0046347086,
0.023794688,
0.038524736,
0.012143073,
0.0012303479,
0.00020242721,
0.005358242,
0.005003301,
-0.00877796,
0.0131328115,
0.028586391,
-0.025364619,
-0.019767476,
-0.045841977,
0.018443273,
0.017774345,
-0.012641355,
0.011296676,
-0.012538969,
0.0104093235,
0.0053957836,
0.013890474,
0.020491008,
-0.018811865,
0.029487394,
0.009494668,
0.011098728,
-0.0073377197,
-0.03945304,
0.03587633,
0.002928262,
0.043821543,
0.018975684,
-0.0029129041,
0.0093445005,
0.00010137358,
0.033992413,
-0.013057728,
0.00821142,
-0.025897032,
0.029241666,
-0.017760694,
-0.0038633947,
0.008805264,
-0.020313539,
-0.0023497767,
0.0063411547,
-0.01875726,
-0.008368413,
0.0020630937,
0.030279186,
0.0046620118,
0.04813544,
-0.01728289,
-0.026415791,
0.0073991516,
-0.012327369,
-0.029296272,
-0.0039555426,
-0.027644431,
0.015508185,
-0.010545839,
-0.013549184,
0.013276153,
-0.013460449,
-0.010218201,
-0.03707767,
-0.032217707,
0.029214364,
0.022361275,
0.0010460516,
-0.020545615,
-0.009515145,
0.034456566,
0.019480793,
0.015835823,
0.02363087,
-0.00149826,
0.0039009366,
-0.0115151005,
0.00627631,
0.008880347,
-0.003249074,
-0.044586033,
0.0030033458,
0.016914297,
0.007945214,
0.014402408,
-0.010491232,
-0.0067404634,
-0.02657961,
0.011713048,
-0.0002495678,
0.008334285,
-0.00425929,
0.00013448931,
0.019180458,
0.010559491,
0.0007913645,
-0.011781306,
0.014361453,
-0.028914029,
-0.0005439298,
-0.010846173,
0.02328958,
0.021774257,
0.018921077,
-0.002472641,
-0.008928128,
0.000454768,
0.0027303144,
0.018061029,
0.0160679,
-0.013269328,
-0.005648338,
0.006074949,
-0.029924244,
-0.0096789645,
0.027985722,
-0.049828235,
-0.024914118,
-0.0048258305,
0.0025408987,
0.01394508,
0.006562993,
-0.03006076,
0.0046654246,
-0.008723354,
-0.006088601,
-0.013603791,
-0.016299976,
-0.0029299685,
0.015344366,
0.02354896,
-0.006917934,
0.0011399062,
-0.0024641086,
0.0008779667,
0.0051125134,
0.008170465,
-0.03467499,
0.0011433191,
0.0015801694,
0.011283023,
0.00029692167,
-0.009528797,
-0.008832566,
-0.02398581,
-0.042975146,
-0.003948717,
-0.01710542,
0.0169416,
0.0816364,
0.0015741969,
-0.008750658,
0.01103047,
-0.024122326,
0.0067541148,
-0.006651728,
-0.000064631655,
0.019562703,
-0.020177022,
0.023139413,
-0.022798125,
0.028586391,
-0.018061029,
-0.03377399,
0.00668927,
0.0036347308,
0.01676413,
0.014675439,
-0.021214541,
0.011583358,
-0.010027079,
0.015453579,
-0.007037385,
-0.0039077625,
0.0063275034,
0.010238678,
-0.014115725,
-0.015658353,
-0.0051773586,
0.016996207,
0.017351147,
-0.03492072,
-0.020463705,
0.020641176,
-0.015849475,
-0.005201249,
-0.020136068,
-0.015057683,
0.0015631049,
-0.015562791,
0.014525272,
0.014921168,
-0.0015963806,
-0.020477356,
-0.0111396825,
-0.018129287,
-0.025951637,
-0.020586569
] |
Previous results have demonstrated that the silencing of adjacent genes encoding NADPH-dependent furfural oxidoreductases (yqhD dkgA) is responsible for increased furfural tolerance in an E. coli strain EMFR9 [Miller et al., Appl Environ Microbiol 75:4315–4323, 2009]. This gene silencing is now reported to result from the spontaneous insertion of an IS10 into the coding region of yqhC, an upstream gene. YqhC shares homology with transcriptional regulators belonging to the AraC/XylS family and was shown to act as a | [
-0.014577372,
-0.02654428,
-0.008648874,
-0.028715087,
-0.048334774,
0.027780816,
-0.019660903,
-0.004781268,
-0.022999547,
-0.016665742,
0.025101658,
-0.018520543,
0.009164097,
0.04322376,
-0.013704928,
0.01025637,
0.027203767,
0.0033953185,
0.007851996,
0.00797565,
-0.011740211,
0.026846545,
-0.016610784,
-0.009129749,
-0.013299619,
0.029759271,
0.017503837,
-0.039211895,
-0.041575048,
0.0021295878,
-0.00317549,
-0.004152696,
-0.014810939,
0.012976746,
-0.01404154,
-0.019784557,
0.022711024,
-0.008216087,
0.014371282,
-0.031957556,
0.020375347,
0.01347136,
0.00031385658,
0.0046026576,
0.01404841,
0.007611559,
-0.010709765,
-0.012014997,
-0.013155357,
0.02578862,
0.017613752,
0.023837645,
-0.005104141,
-0.00055343524,
-0.007948171,
0.01461859,
0.018657938,
0.03509011,
-0.0029917273,
-0.0033953185,
-0.0021708056,
0.0026362236,
-0.022449978,
0.013430142,
-0.0033197526,
0.013169096,
0.008848093,
-0.001585169,
0.012028736,
-0.019125072,
0.034595497,
0.014810939,
0.0021278705,
-0.0013163944,
0.039898857,
-0.019138811,
-0.034375668,
0.03245217,
-0.0027323985,
-0.0037096045,
0.02521157,
-0.020650132,
-0.022546152,
0.017957233,
0.021556923,
0.0076046893,
0.013601883,
0.0477852,
0.014591111,
-0.01138986,
0.027190028,
0.041904792,
0.043526027,
0.015552861,
-0.0125920465,
-0.018465586,
0.012482132,
0.046026576,
-0.0022463717,
-0.029127264,
-0.018493066,
-0.0017929755,
0.010201412,
-0.008016868,
-0.022340063,
-0.0012373936,
-0.0066532446,
-0.0038401277,
-0.007797039,
-0.024620783,
0.0018616719,
0.031050764,
0.010015932,
-0.040723216,
0.016734438,
-0.019949429,
0.024387214,
-0.01743514,
-0.020938657,
-0.010799071,
0.026269495,
0.021433271,
-0.00317549,
-0.027025156,
0.037700575,
0.005220925,
0.003153164,
-0.001744888,
-0.028412823,
-0.02923718,
0.020237954,
0.011341772,
0.041849833,
0.018451847,
-0.029869186,
0.026269495,
-0.029127264,
-0.02047152,
-0.01005028,
-0.02676411,
-0.006220457,
0.022449978,
-0.028879957,
0.009006095,
0.010902115,
0.006704767,
-0.000076210046,
0.027931947,
0.00890992,
0.0064780684,
0.0073161647,
-0.012825614,
0.002852617,
0.015442946,
0.026626717,
0.019001419,
-0.0050354446,
-0.0059113237,
-0.008573309,
-0.012207347,
-0.012811875,
-0.01858924,
-0.010386893,
0.0023631554,
0.007281816,
0.027423594,
0.015236857,
0.001570571,
-0.004558005,
-0.023617815,
-0.018190801,
0.010283848,
-0.01743514,
0.006546765,
0.010874637,
0.003661517,
-0.011066987,
-0.0015044507,
-0.016432174,
-0.009651842,
-0.014893375,
0.012440914,
0.03717848,
0.023686511,
-0.0059078885,
-0.0055437977,
0.006144891,
-0.004255741,
0.009033574,
-0.009590015,
-0.018493066,
0.019619687,
0.000247951,
-0.021941625,
-0.611123,
-0.036326647,
-0.011486035,
-0.005488841,
-0.014714764,
0.008958008,
0.002830291,
0.000330816,
0.009322098,
0.006849029,
0.0018530849,
0.0406133,
0.0019990646,
-0.012543959,
-0.009363317,
-0.021969102,
0.022271367,
-0.020402825,
0.021694317,
0.00069340406,
0.012475262,
-0.005358318,
-0.024716958,
0.0010802506,
0.018561762,
0.016913049,
0.03283687,
-0.017077921,
-0.0014932875,
0.00085784605,
-0.024428433,
0.043718375,
0.00032673715,
-0.012866832,
0.053006127,
-0.0011858713,
0.00023464108,
0.016459653,
0.028989872,
0.02010056,
-0.012234826,
0.0047503547,
0.029649358,
0.0026911807,
-0.031765208,
0.027190028,
0.018300716,
0.010860898,
0.014439979,
-0.020677611,
-0.014261369,
-0.0015782993,
-0.027574727,
0.0005457069,
0.01955099,
0.019042637,
0.010407502,
-0.017751144,
0.012234826,
0.018534284,
0.0015568318,
0.039321806,
-0.008064955,
-0.0049667484,
-0.022724763,
-0.004784703,
-0.028605172,
-0.008621396,
0.014165194,
0.007055118,
0.015992517,
0.021598142,
-0.00673568,
0.024222344,
-0.009789234,
0.026063407,
-0.0021158485,
-0.002809682,
0.0068043764,
0.023274334,
0.01137612,
-0.009225924,
-0.03478785,
0.013684319,
0.02654428,
-0.021021092,
-0.0063612848,
0.007872605,
-0.016968006,
-0.02051274,
0.015992517,
0.007419209,
-0.023288073,
-0.028825002,
-0.038937107,
0.019097595,
0.0033936012,
0.001096566,
0.010290718,
-0.0068387245,
-0.0133270975,
-0.030089015,
-0.0125096105,
-0.02409869,
0.019138811,
0.0052106204,
-0.016638264,
0.00721312,
0.023178158,
-0.008209217,
0.0131004,
-0.008168,
-0.015360511,
-0.012372218,
-0.010730375,
-0.027190028,
0.054022834,
0.015346771,
-0.003446841,
-0.019262465,
0.0005903595,
0.012214216,
-0.020677611,
-0.014178933,
0.005832323,
0.044487774,
-0.011286816,
-0.034045927,
0.0055128844,
0.009500709,
0.013299619,
-0.0010450437,
0.010496807,
-0.024057472,
0.016074954,
0.0069142906,
0.03456802,
0.023040766,
0.010950203,
-0.011211249,
-0.03896459,
-0.014247629,
0.0017526164,
0.014069019,
0.004856834,
-0.003627169,
-0.017696187,
-0.0010270108,
0.0096174935,
-0.016748177,
0.008793137,
0.011328033,
-0.016913049,
0.0012373936,
-0.0030380974,
-0.012949267,
-0.015827646,
-0.018245758,
-0.016432174,
-0.013643101,
0.032726955,
0.002516005,
-0.016775656,
0.0029470746,
-0.019317422,
-0.001189306,
0.004990792,
0.0050526187,
-0.008236696,
-0.0048980517,
-0.023741469,
-0.025307747,
-0.007556602,
-0.0061929785,
-0.0075978194,
0.015992517,
0.0041252174,
0.00024301345,
-0.005427014,
-0.0042454363,
-0.0008320849,
-0.015827646,
-0.009164097,
-0.016281042,
0.0058391923,
0.020031864,
-0.00483966,
-0.00483966,
0.0063612848,
0.040448427,
-0.038772237,
0.0027530075,
0.0034245146,
0.011101335,
-0.024222344,
-0.004856834,
0.01918003,
-0.0020918048,
-0.0024662002,
0.032864347,
-0.0058288877,
-0.017503837,
0.022175191,
-0.039788943,
0.0012691657,
-0.02694272,
0.009315229,
-0.037645616,
0.010297587,
0.003795475,
-0.0009789234,
0.0019526946,
-0.010963942,
-0.0034949284,
-0.018864026,
0.008332871,
-0.015113204,
-0.0123310005,
-0.015140682,
-0.010675417,
-0.004633571,
-0.0029230309,
0.019853253,
0.009596884,
-0.0042179576,
-0.0025658098,
-0.010606721,
0.020251693,
0.0021467619,
0.013203444,
-0.015841385,
0.004540831,
-0.012454654,
0.0063269367,
0.0071650324,
0.014577372,
0.020801263,
-0.00012021866,
0.04171244,
-0.004918661,
-0.01347823,
-0.009397665,
0.024510868,
0.009473231,
-0.0019664338,
0.007851996,
0.033331484,
0.004327872,
-0.0034914934,
-0.004341611,
-0.00084196,
0.040365994,
-0.0030312277,
-0.02201032,
0.0032647955,
-0.008889312,
0.009658711,
0.008827485,
0.037865445,
0.00692803,
-0.006151761,
0.017957233,
0.011520383,
-0.020416563,
0.0062685446,
-0.011314293,
0.0074741663,
-0.0072955554,
-0.016294781,
-0.008875572,
-0.040558342,
-0.00054356013,
0.001811867,
-0.007865735,
0.0043347417,
0.008958008,
0.007797039,
0.034842804,
0.014907114,
-0.010496807,
-0.008621396,
-0.01876785,
0.03377114,
0.017325226,
-0.015305554,
0.002407808,
-0.021900406,
-0.014096498,
-0.002356286,
0.025912274,
0.013175965,
0.01953725,
0.014920854,
0.005921628,
0.002356286,
-0.00040251785,
0.023260593,
-0.036051862,
0.024071211,
0.00597315,
-0.0039740857,
-0.0018427804,
-0.006721941,
-0.0065879826,
0.047043283,
-0.009596884,
0.020196736,
-0.009280881,
0.005258708,
-0.03759066,
0.001811867,
0.016047474,
0.0040702606,
-0.0020523043,
-0.012042476,
0.005962846,
-0.011424208,
-0.0057945396,
0.020279171,
-0.01879533,
0.0049942266,
-0.04860956,
0.025953492,
0.0036580823,
0.01765497,
0.028879957,
0.004056521,
0.022312583,
0.008951139,
0.013759885,
-0.014948333,
-0.028770044,
0.010812811,
-0.029319614,
-0.015539121,
-0.013533187,
0.037123524,
-0.0193449,
-0.0014074171,
0.0012382523,
-0.0018891505,
-0.044927433,
-0.004152696,
0.015195639,
-0.010407502,
-0.006601722,
-0.000048248472,
0.035227504,
0.019015158,
-0.0009274011,
0.022917112,
0.034980197,
0.012736308,
0.00057447347,
0.012571437,
0.0068215504,
-0.0020145213,
0.0045957877,
0.012227955,
0.0011334902,
0.013169096,
0.0024232648,
-0.00084797095,
0.011396729,
0.021501968,
0.020389086,
0.020773785,
-0.0077489517,
0.0026070275,
-0.004324437,
-0.0258161,
0.013279011,
0.0015061682,
-0.028220473,
0.017215313,
-0.02295833,
-0.032754432,
-0.017407663,
0.017957233,
-0.008854964,
-0.008793137,
0.0046060923,
-0.015456686,
-0.027753338,
-0.0075978194,
-0.0138011025,
0.012866832,
-0.016267303,
-0.017325226,
0.015195639,
0.0009402817,
-0.037260916,
-0.0033541007,
-0.0031256853,
0.004479004,
-0.022326324,
-0.013450751,
0.0063303714,
-0.0107441135,
0.02866013,
0.021021092,
-0.014261369,
0.0015628426,
0.0021433271,
0.0001924572,
-0.008429046,
0.001163545,
-0.0262008,
-0.004441221,
0.003295709,
0.017229052,
-0.024222344,
-0.029539444,
-0.01290118,
-0.001916629,
0.009370186,
0.0023099158,
-0.0014563632,
-0.018080886,
-0.008786267,
0.01213178,
0.030473715,
0.009225924,
-0.020237954,
0.0052518384,
-0.030116493,
-0.0155666,
-0.025980972,
0.0074466877,
-0.021378314,
0.02297207,
0.018108366,
-0.0053171,
0.0013352858,
0.010421241,
-0.012124911,
-0.020155517,
0.009219054,
0.030528672,
0.03451306,
-0.011506644,
0.024332257,
0.0024335692,
-0.0043313066,
0.008209217,
-0.025582531,
0.0235079,
0.01781984,
-0.017325226,
0.019001419,
-0.009129749,
-0.0030174884,
-0.02809682,
0.023865122,
-0.024469651,
0.045861702,
0.014110236,
-0.023109462,
-0.029374572,
0.0029384876,
0.008896181,
0.021034831,
-0.017160356,
-0.012949267,
-0.01384919,
-0.009246533,
0.0037267786,
-0.014261369,
0.005141924,
-0.032397214,
0.0022085886,
-0.0016718982,
0.010112107,
0.009967845,
-0.014316326,
-0.00047014086,
-0.027739597,
-0.017146617,
-0.028165516,
-0.04086061,
-0.0051659676,
-0.010084628,
0.047208153,
0.035227504,
0.035062633,
0.001774084,
0.014137715,
0.025829839,
0.014096498,
-0.0090129655,
-0.018864026,
0.01670696,
-0.030061536,
0.005660582,
0.013237792,
0.0061964137,
0.0129355285,
-0.01858924,
0.024936786,
0.033551313,
-0.012550829,
0.007659646,
0.000022205568,
-0.02618706,
-0.018053409,
0.016968006,
-0.01974334,
0.012756918,
-0.040503386,
0.0023923514,
0.0071032057,
0.005938802,
0.014206411,
-0.005767061,
0.022161452,
-0.026516803,
0.025115397,
0.0069142906,
0.036546472,
-0.025362704,
-0.011362381,
-0.005066358,
-0.006052151,
0.022106495,
-0.014769722,
0.014549893,
0.014481197,
-0.017517576,
0.0052243597,
0.025294008,
-0.0022171757,
-0.028934915,
0.009040443,
-0.032122426,
-0.017050441,
-0.026640456,
0.013038573,
-0.04347107,
0.004365655,
0.02506044,
-0.026269495,
0.015910082,
0.0030707282,
-0.030034058,
0.023576597,
0.01953725,
0.03819519,
-0.028989872,
0.025582531,
0.033881053,
-0.008071825,
-0.00930836,
0.0021708056,
-0.0065776785,
-0.031050764,
0.03357879,
0.030638585,
0.0010252935,
-0.017806102,
0.015813906,
-0.010799071,
-0.022449978,
-0.030583628,
0.015401728,
0.0077146036,
0.0010201413,
-0.0030209234,
-0.00222748,
0.01612991,
0.0033781445,
-0.012097432,
0.028495258,
-0.014398761,
0.009267142,
-0.0011343489,
0.02221641,
0.0046816585,
0.005804844,
0.0034537106,
-0.015360511,
-0.021708056,
-0.026997678,
-0.0032527735,
0.009940366,
-0.0019063245,
0.0406133,
0.007041379,
-0.009212185,
-0.0021622186,
-0.0020007822,
0.005598755,
-0.0018565197,
-0.010538025,
0.034842804,
-0.0070688576,
-0.0076802555,
0.010709765,
-0.012612656,
0.019757079,
0.0006285719,
0.010785332,
-0.014082758,
-0.046191446,
0.013835451,
0.013993452,
0.022298845,
0.00985793,
0.027657162,
-0.010709765,
-0.015195639,
-0.013890408,
-0.017943494,
0.024029994,
-0.030913372,
-0.019317422,
0.00042784965,
0.016542088,
0.017132876,
-0.02032039,
0.0066395053,
-0.010524285,
0.020540217,
-0.02429104,
0.026640456,
0.006409372,
-0.0022549587,
-0.0127157,
0.0028629217,
0.00076381786,
-0.04198723,
0.01974334,
-0.02297207,
-0.01955099,
0.006299458,
-0.013450751,
0.0013945365,
0.0025434834,
-0.009459492,
0.006148326,
0.00056202227,
0.019825775,
-0.007913823,
-0.0075772107,
0.033716183,
-0.02104857,
0.020677611,
0.0319026,
-0.02199658,
0.0013172531,
0.011547862,
-0.02771212,
0.012729439,
-0.0077420822,
-0.024662001,
-0.0056262333,
-0.00043600734,
0.0035309938,
0.0077146036,
0.032726955,
-0.0037679963,
-0.019660903,
-0.008023737,
0.004358785,
0.0070619876,
-0.005832323,
-0.0033111656,
-0.016390957,
0.001346449,
-0.023933819,
-0.012647004,
0.002780486,
-0.0011747081,
-0.03360627,
-0.0010433262,
-0.012976746,
0.012681352,
-0.013519447,
-0.03492524,
-0.014728504,
-0.005591885,
-0.030446235,
-0.025225312,
-0.013897277,
-0.007323034,
0.0045614396,
-0.0064608944,
-0.015497903,
0.0021175658,
-0.010531155,
0.012928659,
0.011403599,
-0.025486358,
-0.022120234,
0.012427175,
0.016006257,
0.0044515254,
-0.029924143,
-0.004187044,
0.02048526,
-0.010331935,
-0.008827485,
0.039761465,
-0.0014958637,
0.02277972,
-0.009610623,
-0.002038565,
0.00474692,
-0.00020072224,
0.012729439,
-0.0058804103,
-0.008511482,
0.014646068,
0.015442946,
-0.0029642489,
0.0047194413,
0.0012717417,
0.0035584725,
-0.009576275,
-0.006608592,
-0.030418757,
-0.0035172547,
-0.021666838,
0.018726634,
0.019413598,
-0.009981584,
-0.00275129,
0.01784732,
-0.033661228,
-0.00871757,
-0.0014924288,
-0.037453268,
-0.01971586,
0.013299619,
-0.020086821,
0.010304457,
-0.02240876,
-0.002873226,
-0.00702077,
-0.013210313,
0.0053274045,
-0.016212346,
-0.009954105,
0.018438108,
-0.011259337,
-0.0069417693,
-0.023411727,
-0.013306489,
-0.030638585,
0.001253709,
-0.0075085144,
0.00815426,
-0.0069520734,
0.0068971165,
0.0020557393,
-0.013553795,
-0.0035344288,
-0.014755982,
-0.004056521,
-0.0068352898,
0.02069135,
0.18003947,
0.01118377,
0.016830614,
0.0067425496,
-0.009342708,
-0.01876785,
-0.00232709,
-0.0075772107,
-0.009638102,
0.030446235,
0.012777527,
0.009432013,
-0.006591418,
-0.0029625313,
0.0185755,
-0.012083693,
-0.045064826,
-0.0006371589,
-0.040723216,
-0.0114310775,
0.030995807,
-0.018245758,
-0.005955976,
-0.017407663,
0.05064297,
0.004819051,
-0.026090885,
0.0072337287,
0.013787364,
0.01422015,
-0.030198928,
0.0068181157,
0.011747081,
-0.011637167,
0.014165194,
0.006419677,
-0.009452621,
-0.009026704,
0.0047160066,
0.0043553505,
0.017861059,
-0.0056571467,
-0.006622331,
0.0024473085,
-0.015813906,
-0.007989389,
0.003795475,
0.0128530925,
-0.03456802,
-0.015429207,
-0.031600334,
0.00987167,
-0.0025314617,
0.028495258,
0.024400955,
-0.02124092,
0.0116440365,
-0.002390634,
0.008848093,
0.018534284,
-0.015333032,
0.01574521,
-0.03154538,
0.017902277,
-0.033633746,
0.038112752,
-0.029099787,
0.011417339,
0.024236083,
-0.018369412,
-0.024607044,
0.0008359491,
-0.002789073,
0.014439979,
0.014687286,
-0.021694317,
0.010318196,
0.0026997677,
0.033661228,
0.026448106,
-0.0065158517,
-0.0066051567,
-0.026090885,
0.005289621,
-0.017586274,
-0.05732026,
0.0062925885,
0.00664294,
-0.011719602,
-0.009397665,
0.0013086661,
0.022765981,
-0.013656841,
-0.027038895,
-0.00464731,
-0.0029092918,
0.0028663564,
-0.0023631554,
-0.0049427045,
-0.013107269,
-0.032534607,
0.043526027,
-0.017613752,
0.01042811,
-0.038607366,
0.032424692,
-0.0018719763,
0.0032819696,
-0.007687125,
-0.009061052,
-0.0013644819,
-0.02030665,
0.001820454,
-0.007487905,
0.007515384,
0.0062341965,
0.0307485,
-0.026530541,
0.025156613,
-0.0017002354,
-0.008793137,
-0.033881053,
-0.006694462,
0.026626717,
-0.01860298,
-0.0061380216,
-0.016349738,
0.0030758805,
-0.019138811,
-0.04707076,
0.0193449,
0.012846223,
0.000594653,
0.010641069,
0.032562084,
0.01648713,
0.0026516803,
-0.028192995,
-0.019056376,
0.027684642,
0.0056468425,
0.008250435,
0.03528246,
0.00502514,
-0.017998451,
-0.032314777,
0.015882604,
-0.012832484,
-0.024387214,
-0.010208282,
-0.025898535,
-0.024964264,
-0.00890992,
-0.008882442,
0.019413598,
-0.019331161,
-0.0013507425,
-0.022449978,
0.0072612073,
0.020732567,
-0.0568806,
0.0059937593,
0.011259337,
-0.014439979,
0.015333032,
0.01746262,
-0.17388427,
-0.00407713,
0.011843256,
-0.025719924,
0.021763014,
0.02372773,
0.0049049216,
0.0008217805,
-0.0322873,
0.007110075,
0.027011417,
0.019853253,
-0.038854674,
-0.032534607,
0.0025297443,
0.020567697,
-0.03338644,
0.032342255,
0.01652835,
0.007797039,
0.021845449,
-0.008133652,
0.018314455,
-0.010579242,
0.0060109333,
0.03489776,
0.004056521,
-0.013684319,
-0.02654428,
-0.01632226,
-0.030666064,
0.017723667,
0.034155842,
-0.023040766,
0.027808294,
-0.004946139,
-0.01630852,
-0.0125920465,
0.009061052,
0.013244662,
0.013862929,
0.023755208,
0.017572533,
0.016418435,
-0.031353027,
0.026296975,
-0.0075359927,
-0.0052621425,
0.0044652647,
0.00011871593,
0.012942398,
0.0021330225,
0.018328194,
0.020746307,
0.025733665,
-0.0010416089,
-0.013732406,
-0.00005753322,
-0.0022704154,
-0.023865122,
0.012365349,
-0.02258737,
0.02313694,
-0.00046026576,
-0.002315068,
-0.024318518,
-0.028879957,
0.0127225695,
-0.03149042,
-0.00011442241,
-0.03206747,
-0.017380184,
0.0015997669,
-0.0066463747,
0.012798135,
-0.0086694835,
-0.0047022672,
0.0013498839,
-0.02199658,
-0.007082597,
-0.03129807,
0.023068244,
-0.024936786,
0.015813906,
0.0017165508,
0.024167387,
0.00046799408,
0.025967231,
-0.009734277,
0.013753016,
0.021721795,
-0.018245758,
0.00398439,
-0.012564568,
0.02464826,
0.011671515,
-0.0017380184,
0.021117266,
-0.010517416,
0.019056376,
0.008642005,
-0.013773624,
-0.026887763,
0.00038341168,
0.026860284,
-0.031023284,
-0.010950203,
-0.0100090625,
0.07342269,
-0.0151819,
-0.0032373169,
-0.0120356055,
0.006907421,
0.023370508,
-0.0040530865,
0.009040443,
-0.0023923514,
-0.014192672,
0.0011618275,
-0.026035927,
0.05808966,
0.009061052,
-0.0056296685,
0.0116921235,
-0.026393149,
-0.021103527,
-0.12903927,
0.001992195,
0.005169403,
0.009095401,
-0.006852464,
0.0058117136,
0.0030295104,
0.038469974,
-0.010180804,
0.02729994,
0.007948171,
-0.031407986,
0.0027358334,
0.0025950058,
0.012667612,
-0.0034073405,
0.0075978194,
-0.009590015,
-0.020430304,
0.030116493,
0.00007508299,
-0.01006402,
0.010586112,
-0.0006298599,
-0.004187044,
0.0051110107,
-0.035557248,
0.012825614,
0.007948171,
0.041107915,
0.011101335,
-0.023191897,
0.024057472,
-0.0022000016,
-0.02335677,
-0.01137612,
0.019070115,
-0.015044508,
0.054352574,
-0.006807811,
0.005643408,
-0.0053480132,
0.015690254,
0.020073082,
0.022834677,
0.012832484,
0.00032952795,
0.033716183,
0.0012262304,
-0.008951139,
-0.05012088,
-0.021433271,
-0.025706185,
-0.013340837,
0.03585951,
-0.03509011,
0.029511964,
0.0284403,
-0.03456802,
-0.00034219385,
0.01270196,
0.013608753,
-0.00569493,
-0.0007084314,
-0.0075016445,
-0.026406888,
-0.007364252,
-0.04459769,
0.0319026,
-0.026722891,
-0.0060040634,
0.019647164,
-0.004667919,
-0.006890247,
-0.022711024,
0.013698058,
-0.036958653,
-0.025967231,
0.006110543,
-0.022903373,
-0.014810939,
-0.015676513,
0.009981584,
-0.028742565,
0.017187834,
0.01442624,
0.0020523043,
-0.006093369,
0.016171128,
-0.008703832,
-0.035832033,
0.030281365,
-0.0047675287,
-0.029127264,
-0.020430304,
0.027313681,
0.016418435,
-0.005238099,
0.017792363,
0.015319292,
-0.018712893,
-0.029072309,
-0.058364443,
0.013553795,
0.019468553,
-0.0044343513,
-0.004856834,
0.008875572,
0.014467457,
0.02124092,
-0.0013979713,
0.031655293,
-0.016734438,
0.032919306,
-0.028110558,
-0.037343353,
-0.008518351,
-0.016212346,
0.048142422,
-0.013862929,
0.033496354,
0.01667948,
-0.0016401261,
0.025129136,
0.0075978194,
0.030006578,
-0.027725859,
0.00021789633,
-0.030473715,
0.010895246,
-0.004156131,
0.001451211,
0.011410468,
-0.028687607,
-0.025610011,
0.0019784558,
-0.009988453,
-0.0053239693,
-0.008126781,
0.014673547,
0.003761127,
0.015470425,
-0.030721022,
-0.033853576,
0.014467457,
0.005220925,
0.013127878,
0.022765981,
-0.030775977,
0.01993569,
0.013814842,
-0.0029676836,
0.022243887,
0.0032854043,
0.008374088,
-0.017902277,
-0.020622654,
-0.0015800167,
-0.007529123,
-0.017022964,
-0.0062135877,
-0.033936013,
0.00796878,
0.009191575,
0.02106231,
0.01878159,
0.0039569116,
-0.0046644844,
-0.010799071,
-0.0142751075,
0.031600334,
-0.046054054,
-0.023054505,
-0.004822486,
0.004472134,
0.016336,
0.0017758014,
-0.0010330218,
-0.019921951,
0.0008050357,
-0.0185755,
0.010517416,
0.02714881,
-0.014948333,
0.014673547,
0.018300716,
0.024181126,
0.0029195962,
0.0059319325,
-0.0020986744,
0.0131004,
0.022312583,
-0.013224053,
0.025980972,
-0.0050594886,
-0.0060693254,
0.005334274,
0.02523905,
0.010702896,
0.00006123638,
0.010929594,
0.025555054,
-0.008209217,
0.0044652647,
0.0026568326,
-0.024373475,
-0.0053067952,
0.019399857,
-0.018369412,
-0.03154538,
-0.036134295,
0.01384919,
-0.00928775,
-0.016734438,
0.007838257,
0.0019853255,
-0.008600786,
0.028028123,
-0.012667612,
-0.018726634,
-0.018534284,
0.012729439,
0.020773785,
0.006495243,
-0.011877604,
-0.0019423901,
0.033661228,
0.002084935,
0.027918208,
-0.014123975,
0.023631554,
-0.02297207,
0.028715087,
0.013945365,
-0.01498955,
-0.019083854,
0.0020007822,
-0.0038538668,
-0.0032939913,
-0.013189705,
-0.008614526,
0.06880629,
0.017325226,
-0.02161188,
0.019963168,
-0.008772528,
0.028014384,
-0.007116945,
0.017943494,
-0.005471667,
-0.043333676,
0.035062633,
-0.007075727,
0.02201032,
-0.030830935,
-0.017943494,
0.0032613606,
0.022298845,
0.021749275,
0.0026104625,
-0.019441076,
0.016294781,
-0.012172999,
-0.0047434852,
0.0067837676,
-0.02749229,
-0.027038895,
0.043361153,
0.005179707,
0.012269174,
-0.030336322,
-0.0011927409,
0.0042351317,
-0.00041904792,
-0.017229052,
-0.0002118854,
-0.010977682,
-0.014261369,
-0.0037473876,
0.027038895,
0.017861059,
0.0038366928,
-0.010263239,
-0.007171902,
-0.01916629,
0.002684311,
0.013842321,
-0.01784732,
0.013952235,
-0.01328588
] |
Compartmentalization of signals generated by receptor tyrosine kinase (RTK) endocytosis has emerged as a major determinant of various cell functions. Here, using tumour-associated Met-activating mutations, we demonstrate a direct link between endocytosis and tumorigenicity. Met mutants exhibit increased endocytosis/recycling activity and decreased levels of degradation, leading to accumulation on endosomes, activation of the GTPase Rac1, loss of actin stress fibres and increased levels of cell migration. Blocking endocytosis inhibited mutants’ anchorage-independent growth, in vivo tumorigenesis and metast | [
-0.02461817,
-0.018827213,
-0.000016784927,
-0.022872949,
-0.021630142,
0.015442546,
-0.022872949,
0.0019336236,
-0.024578504,
0.0046605286,
0.030329796,
-0.014160074,
0.0132544115,
-0.0030904924,
-0.01575986,
0.0043663536,
0.03778664,
0.0011758745,
-0.033450037,
0.0066239005,
-0.015468989,
0.022820065,
-0.007265136,
-0.03736356,
-0.004448987,
0.020030357,
0.014675708,
-0.047623333,
-0.008521166,
-0.024882596,
-0.003973018,
0.019594053,
-0.023137376,
-0.015138455,
-0.0035697666,
0.009459882,
0.029430743,
-0.0034639959,
0.015217783,
0.007271747,
0.0062338705,
0.0038011405,
-0.0073048,
-0.002997943,
-0.004257277,
0.0112315435,
-0.00029252254,
-0.013499007,
-0.016473813,
0.02025512,
0.010815071,
0.0028260653,
-0.012877603,
0.0037879192,
-0.02122028,
-0.009380554,
-0.015508653,
0.018734664,
0.005860367,
-0.028452363,
0.0023649705,
-0.011264597,
-0.033529364,
0.01412041,
0.0016568014,
0.014926913,
0.015178119,
-0.0072188615,
-0.011416643,
0.011132384,
0.03493083,
0.01382954,
-0.008005532,
0.0023286117,
-0.001936929,
-0.017306758,
-0.033740904,
-0.0011601741,
-0.0050902227,
0.014226181,
0.010887789,
-0.025424672,
-0.017359642,
0.04680361,
0.018457016,
0.017941384,
-0.0012023173,
0.019342847,
0.019104863,
0.010464705,
0.005890115,
0.025345344,
0.007470067,
0.016619246,
-0.008574051,
0.0071197012,
-0.020704648,
0.030699993,
0.0021534287,
-0.048178628,
-0.015720194,
0.0016956392,
-0.0045217043,
-0.022555636,
-0.017703399,
0.009056631,
-0.00024252929,
0.005909947,
0.020400556,
-0.016063951,
-0.031017305,
0.026588151,
-0.010656415,
-0.022383759,
0.03347648,
0.01168768,
0.021564035,
0.012077711,
-0.023137376,
-0.0054637264,
0.0012899088,
0.021921013,
0.02510736,
-0.009281393,
0.030118253,
-0.008203853,
-0.010180445,
-0.0013890689,
-0.00787993,
0.0025269322,
0.0009527641,
0.009565652,
0.0050208108,
0.014292288,
-0.020215457,
0.012249588,
-0.01586563,
0.002151776,
-0.026455937,
-0.039769843,
-0.0031764312,
0.025345344,
-0.010140781,
-0.0045878114,
-0.0057413746,
-0.003708591,
0.03368802,
0.009982125,
0.025305679,
-0.0029946377,
0.008170799,
-0.019951029,
-0.0069015487,
-0.021590477,
0.00068751065,
0.01684401,
-0.0042275293,
0.01566731,
-0.01412041,
-0.014834364,
-0.0029467102,
-0.013591556,
0.0161565,
-0.007066816,
0.049500763,
0.023613345,
0.03456063,
0.018866878,
-0.003573072,
-0.009261562,
0.014437723,
0.009083073,
-0.020916188,
0.025133802,
-0.0033664883,
0.022753958,
-0.011515803,
0.00818402,
-0.035063043,
-0.007912983,
-0.02131283,
0.013935312,
0.019739488,
-0.0002462478,
-0.018615672,
0.002036089,
0.012474352,
-0.007271747,
-0.001260987,
-0.017584406,
-0.0018377688,
0.0134593425,
-0.023216704,
-0.008732707,
-0.6295482,
-0.021378936,
0.012646229,
-0.0076485556,
-0.0037680871,
0.036490947,
0.025305679,
-0.005384398,
-0.0029103514,
0.0057810387,
-0.02482971,
0.018708222,
0.0102333315,
-0.023785222,
-0.013644442,
-0.02666748,
-0.012355359,
-0.012057879,
0.021590477,
0.014834364,
-0.026799694,
0.004934872,
-0.026707143,
0.01256029,
0.0025071,
0.016037507,
0.027632639,
-0.0052323523,
-0.005245574,
0.033317823,
-0.03202213,
0.009757362,
-0.007146144,
-0.00036875193,
0.05217148,
0.018007489,
0.0071593653,
0.048178628,
0.005609161,
0.044899732,
0.013763433,
0.009003744,
0.019845258,
0.011317482,
-0.027711967,
0.011932275,
-0.0030260384,
0.013505617,
-0.0013973323,
-0.016315157,
0.0037449496,
0.0094268285,
-0.021524372,
0.0067296713,
0.016394485,
-0.0073709073,
0.012752,
-0.0022988636,
0.01694978,
0.002697157,
0.0049613146,
0.0397434,
-0.004280415,
-0.020770753,
0.011224933,
0.011892611,
0.00856083,
0.013485786,
-0.0033813624,
0.010689468,
0.024591725,
0.032577425,
-0.0010271342,
0.035406798,
0.015799522,
0.04236123,
0.0018030627,
0.0044126282,
-0.012606565,
0.017240651,
0.014358395,
0.002997943,
-0.03125529,
0.002968195,
0.01575986,
0.017769504,
-0.011529025,
0.019527946,
0.029324973,
-0.004809269,
-0.0016146584,
0.0058074817,
-0.030356238,
-0.02911343,
-0.035988536,
0.028293706,
0.0016972919,
0.023296032,
-0.0021616921,
-0.0100284,
-0.037522215,
-0.025424672,
0.012157039,
-0.0077543263,
0.008058418,
-0.023110934,
-0.033053394,
-0.008507944,
0.03585632,
-0.030303353,
0.0007209772,
-0.012738778,
0.012163649,
-0.022701072,
-0.01985848,
-0.024578504,
0.01956761,
0.022344096,
-0.0043465216,
-0.014450944,
-0.0027302105,
-0.007225472,
0.012752,
-0.0063925264,
0.011608352,
0.020532768,
0.01012756,
-0.027315326,
-0.016434148,
-0.009856522,
-0.011264597,
-0.015746638,
0.024763603,
-0.011806672,
0.022463087,
0.0045613684,
0.022899393,
-0.006541267,
0.0154293245,
-0.044053566,
-0.032392327,
-0.018139703,
0.021405378,
-0.011601741,
-0.013789876,
-0.015746638,
-0.0023864552,
-0.008276571,
0.01684401,
0.0035664614,
-0.0031070192,
0.0038507206,
-0.009393775,
0.0064189695,
0.020876525,
-0.019818816,
-0.012269421,
-0.016711796,
0.0038242778,
-0.006726366,
-0.0032838548,
-0.0037152015,
-0.02435374,
0.0069742664,
-0.015892072,
-0.0047001927,
0.0043399106,
-0.010398598,
-0.0043167733,
-0.039214548,
-0.008349287,
-0.012811496,
-0.021140952,
0.008719485,
-0.0007052768,
0.029933155,
-0.014847585,
-0.0028789507,
0.001736956,
-0.0028789507,
0.016315157,
-0.031387504,
-0.014252624,
0.0019286656,
0.028055722,
0.010537422,
0.023481132,
0.015627645,
-0.0074832886,
0.031387504,
-0.015231005,
0.011145605,
-0.009387164,
0.016989445,
0.0056917947,
-0.039161664,
0.02423475,
0.019924587,
-0.0124479085,
0.04156795,
-0.007390739,
-0.010345712,
0.0013725422,
-0.007866708,
0.016182942,
0.018853657,
-0.008051807,
-0.030594222,
0.013948533,
0.0063065877,
0.006237176,
0.036173634,
0.0025500695,
0.008104692,
-0.0039135218,
0.020969074,
-0.0028442447,
-0.0045217043,
-0.020783976,
-0.024988366,
-0.0068618846,
-0.0061776796,
0.0006837921,
-0.010094507,
-0.015442546,
0.014688929,
0.001811326,
0.013208137,
-0.0041217585,
-0.024208307,
-0.014874028,
0.019805595,
0.018430574,
0.020519547,
0.01624905,
0.009724309,
0.001946845,
0.002082364,
0.041991033,
0.01206449,
0.024419848,
0.009023577,
0.0015121928,
0.0019732877,
-0.001766704,
-0.001288256,
0.031070191,
0.021749133,
-0.010094507,
0.00041192793,
0.015720194,
0.02861102,
-0.007946036,
-0.006200817,
0.0027897065,
-0.008104692,
0.01256029,
0.019686602,
0.05965477,
0.0039102165,
-0.0044159335,
-0.018020712,
0.007833655,
-0.002222841,
-0.009697866,
0.034481302,
0.020228678,
-0.016447369,
0.0070734266,
0.01450383,
-0.021339271,
-0.007661777,
-0.00029086988,
-0.036147192,
0.0023649705,
0.008587272,
0.017478636,
0.0026409663,
0.011529025,
0.025067694,
-0.0062074275,
-0.041356407,
0.02617829,
0.033582248,
0.0045415363,
-0.025252795,
-0.017081995,
-0.00064784655,
0.0016791124,
0.016315157,
0.013168473,
0.010372155,
0.0041316743,
-0.013816319,
-0.033026952,
-0.014926913,
0.012031436,
-0.03593565,
0.023824887,
-0.004878681,
0.008864921,
-0.017108437,
-0.022476308,
0.014860806,
0.027421096,
-0.0013783266,
-0.0009354111,
-0.008838478,
-0.013538671,
-0.04632764,
-0.003047523,
-0.0025104054,
-0.017386086,
-0.030911535,
-0.010444873,
-0.004739857,
-0.0016832441,
-0.018602451,
0.032180786,
0.000019806213,
-0.02579487,
-0.02200034,
-0.012857771,
-0.0022558942,
0.029642284,
0.019554388,
-0.011105941,
0.010345712,
-0.008884752,
-0.006465244,
-0.0022707682,
-0.036940474,
0.005129887,
-0.030964421,
-0.014702151,
0.0031615573,
-0.0013452732,
-0.0008643463,
0.015349996,
0.017769504,
-0.010530812,
-0.0227804,
-0.008005532,
-0.019911366,
0.019884922,
-0.010391988,
0.018285139,
0.028901888,
0.033635136,
-0.0075956704,
0.02063854,
0.026760029,
0.018483458,
-0.025199909,
0.014583158,
0.014384838,
0.002126986,
-0.00038383255,
-0.0055628866,
-0.05402247,
0.009611927,
0.0039564916,
-0.016817568,
-0.001396506,
0.005519917,
0.01575986,
0.019051977,
-0.0063198092,
-0.00399285,
-0.004505178,
0.012646229,
-0.0045283153,
0.0015716889,
-0.015468989,
0.02765908,
-0.019144526,
-0.009288004,
-0.010649804,
0.0071130907,
0.012209924,
0.008230295,
-0.0018856962,
-0.009942461,
-0.006987488,
0.006270229,
-0.0012213229,
-0.0061909007,
-0.023600124,
-0.009651591,
-0.011985161,
0.012692504,
-0.018047154,
-0.0086335465,
0.01819259,
0.01675146,
-0.028320149,
-0.012877603,
0.0044754297,
0.01889332,
0.0202419,
0.0037052855,
0.00224102,
-0.0048522386,
0.03350292,
-0.019012313,
0.013062702,
-0.027526867,
-0.042757872,
0.0032722862,
-0.014318731,
0.008997134,
-0.019990694,
-0.01694978,
0.008732707,
0.012599954,
-0.01412041,
0.00070858217,
-0.003333435,
-0.007489899,
0.002231104,
-0.002287295,
-0.00180141,
-0.003183042,
0.018033933,
-0.0076485556,
-0.0014733551,
-0.019461839,
0.0044060177,
-0.01956761,
-0.023877773,
0.00676603,
0.01158852,
-0.018113261,
0.0038507206,
0.0003782548,
-0.016103614,
-0.013670884,
-0.003582988,
0.015535096,
0.021537593,
0.012837939,
0.008322845,
0.019342847,
0.008336066,
-0.016526697,
-0.007919594,
0.016923338,
-0.0062074275,
-0.003982934,
0.0023666231,
-0.0061214888,
-0.01031266,
-0.021405378,
-0.005625688,
-0.01947506,
0.017703399,
0.007893151,
-0.016434148,
-0.002586428,
0.019739488,
-0.0138559835,
-0.013062702,
0.014464166,
-0.017399307,
-0.026522044,
0.015812743,
-0.001961719,
-0.011172048,
-0.0004722504,
-0.044238664,
-0.0063264198,
0.029298529,
0.001741914,
0.00618429,
0.014622822,
-0.00088004663,
-0.033317823,
-0.0050108945,
-0.022066446,
-0.044503093,
-0.01635482,
0.020823639,
0.03924099,
0.042678542,
0.034296203,
0.0005908294,
0.045402143,
0.0047068032,
0.011727344,
-0.00037143752,
-0.0011527372,
0.02045344,
-0.026363388,
0.0034309423,
0.00847489,
-0.00006528045,
0.028161492,
0.009486324,
0.016553141,
0.0006523914,
-0.011086109,
-0.005430673,
0.0075031207,
-0.032392327,
-0.023600124,
0.04117131,
-0.017981047,
0.0021071539,
-0.044265106,
0.008117914,
0.019554388,
0.01985848,
-0.009023577,
0.0011552161,
0.011661238,
-0.037733756,
0.020030357,
-0.03463996,
-0.026244396,
0.009644981,
-0.011357146,
0.0024442985,
-0.020691425,
0.0094136065,
-0.009611927,
0.0012328917,
0.0064883814,
-0.0021435127,
0.0070535946,
-0.015482211,
0.0049414826,
-0.0094136065,
-0.00418456,
-0.0041415906,
-0.029298529,
-0.009876355,
-0.007833655,
-0.035327468,
-0.005774428,
0.022132553,
-0.021008737,
0.007509731,
0.0032293168,
0.0038209725,
0.024935482,
0.0013295729,
0.027011234,
-0.0037019802,
-0.005285238,
0.004468819,
0.0018179368,
-0.027976394,
-0.009863134,
-0.023890994,
0.027447538,
0.037442885,
0.028531691,
-0.0012948668,
-0.0060421606,
0.004848933,
0.007165976,
-0.023203483,
-0.028901888,
0.019726267,
-0.009089684,
0.0023401803,
-0.018245474,
-0.00511336,
-0.020070022,
0.0027037677,
-0.01158191,
-0.00081270037,
-0.00047514256,
-0.008812035,
-0.039214548,
0.035962094,
0.015852408,
0.030990863,
0.007470067,
-0.011542246,
-0.003513576,
-0.013300686,
0.0017452192,
0.017505078,
-0.016024286,
0.015231005,
-0.0038044457,
-0.017214209,
0.026310503,
-0.0026145235,
0.008144356,
-0.015098791,
-0.011033223,
0.044503093,
0.0034871332,
-0.01100017,
0.012434687,
-0.0063726944,
0.0043994067,
0.012917267,
0.014517051,
-0.011899223,
-0.011846337,
-0.008712875,
0.017676955,
0.008051807,
-0.0013237884,
-0.0022195354,
-0.01109933,
0.0060091075,
-0.030885093,
-0.028584575,
0.001761746,
-0.039981388,
-0.0018493375,
0.005995886,
0.015032684,
0.0319428,
0.004253972,
0.005361261,
-0.008527776,
0.05071713,
-0.027209556,
0.022489531,
0.002817802,
0.0033036869,
-0.0080319755,
0.0104250405,
-0.011991772,
-0.030197581,
0.023110934,
-0.015640866,
-0.022925835,
-0.016288713,
-0.01722743,
0.014160074,
0.0147947,
-0.015561539,
0.020426998,
0.004032514,
0.00963837,
0.0031086719,
-0.012963542,
0.008382341,
-0.02773841,
0.01761085,
0.010008568,
-0.013247801,
-0.014543494,
0.005169551,
-0.018258696,
-0.001786536,
0.0049183453,
-0.015336775,
-0.028478805,
0.0027897065,
-0.009869744,
0.01080846,
0.0037515603,
-0.014807921,
-0.02062532,
0.0050208108,
0.016764682,
-0.015151677,
-0.014279067,
-0.006590847,
-0.0051067495,
0.003728423,
-0.016050728,
0.00061644585,
-0.0036590109,
-0.003592904,
-0.006855274,
-0.007212251,
-0.008058418,
0.028187936,
0.008871531,
-0.022621743,
-0.02492226,
-0.002242673,
-0.052224364,
-0.029774498,
0.0063396413,
0.0024756994,
0.011218322,
0.00818402,
-0.024816489,
0.006782557,
-0.0038176673,
0.010993559,
-0.0138427615,
-0.0028739928,
0.023454688,
-0.0066569536,
0.0020906273,
0.0066536483,
-0.02629728,
-0.02131283,
0.037337117,
-0.006346252,
-0.0042671934,
0.017452193,
-0.0019038756,
0.008038586,
-0.016143277,
0.008012143,
0.020493105,
0.013465953,
0.033370707,
-0.0033747517,
0.004002766,
0.03125529,
0.018047154,
-0.011178658,
0.0086666,
-0.0059529166,
0.032868296,
0.0075361743,
-0.0004891902,
-0.032101456,
0.015363218,
0.0065445723,
0.027606195,
0.041885264,
0.0053910087,
0.001961719,
0.012718947,
-0.009215287,
-0.016103614,
-0.005979359,
-0.010715911,
-0.0003656532,
0.004558063,
-0.00068957644,
-0.00515633,
0.0036524,
0.016235828,
-0.0132279685,
-0.009274783,
0.023798445,
0.008131135,
-0.022251546,
-0.0005916558,
0.0024839626,
-0.025490778,
0.00060487713,
-0.0012419813,
-0.004898513,
-0.019646939,
-0.015627645,
0.008012143,
-0.005364566,
-0.015310333,
-0.0058273138,
-0.005195994,
0.0055827186,
-0.028002836,
-0.020783976,
-0.012104154,
0.013710548,
0.18033932,
-0.021299608,
-0.007939425,
0.015812743,
-0.0038408046,
-0.033793792,
0.010927453,
-0.0016030896,
0.008342677,
-0.008931028,
0.009314447,
0.020916188,
-0.009202065,
-0.0055959397,
0.015297111,
0.013353571,
-0.03154616,
-0.013274243,
-0.026442716,
0.00915579,
0.009393775,
-0.017676955,
0.009016966,
-0.0050108945,
0.03863281,
-0.011119162,
-0.02112773,
-0.01246113,
0.031387504,
0.0046109487,
-0.031281732,
-0.00037970088,
0.014847585,
0.0013560156,
0.0062107327,
0.009849912,
-0.026799694,
-0.0034904385,
0.012745389,
0.00013903085,
-0.0046473076,
-0.0094400495,
-0.003257412,
-0.0012204966,
-0.014252624,
0.02013613,
-0.0054108407,
-0.015006241,
-0.00292192,
-0.0003766021,
-0.045031946,
0.0017105133,
0.0241422,
-0.013578335,
0.0010378766,
-0.010325881,
0.012804885,
0.010947284,
-0.005460421,
0.025266016,
-0.023150599,
0.0071791974,
-0.0142658455,
-0.012917267,
-0.020572433,
0.02239698,
-0.026059296,
0.012434687,
0.019832037,
-0.033635136,
-0.0032607175,
0.008626936,
0.000019844949,
0.0011147257,
0.00039767366,
-0.013181694,
0.008527776,
0.01168107,
0.03805107,
0.027579753,
0.017862055,
0.026403053,
-0.01898587,
-0.010001957,
-0.02083686,
-0.02608574,
0.02190779,
0.012824717,
-0.009043409,
0.019924587,
-0.0038870792,
-0.017478636,
-0.0077080517,
-0.0046208645,
0.019356068,
-0.00083666405,
0.0011428212,
0.00009229128,
-0.0052984594,
-0.007251915,
-0.031228848,
0.092179306,
0.014583158,
0.004809269,
-0.0082236845,
0.0026806304,
-0.0034904385,
0.023957102,
0.000033750614,
-0.009473103,
0.010544033,
-0.035274584,
0.008983913,
0.003417721,
-0.011006781,
0.009307836,
0.002512058,
-0.007027152,
0.03585632,
-0.0069346023,
-0.02326959,
-0.022925835,
0.010160614,
0.009545821,
-0.007846876,
0.027897066,
-0.017042331,
0.010504369,
0.011363757,
-0.026165068,
0.0013584945,
0.019554388,
0.002322001,
0.013604778,
0.0031318092,
-0.022211881,
0.014067525,
-0.003642484,
-0.031493276,
0.03300051,
-0.0086203255,
0.00807825,
0.022978721,
0.009294615,
-0.0057248482,
-0.020823639,
0.01849668,
0.0055430545,
-0.032471657,
-0.0058372295,
0.0031962632,
-0.011376979,
-0.016209384,
-0.0010858041,
0.0057413746,
-0.024393406,
-0.0161565,
-0.036252964,
0.0031995687,
0.013750212,
-0.042070363,
-0.002222841,
0.0088516995,
-0.028002836,
-0.012533847,
0.0073841284,
-0.16521409,
0.011138994,
0.014979798,
-0.029748056,
0.014874028,
0.005397619,
0.007291579,
-0.0009800332,
-0.014345174,
-0.0022079668,
0.056375872,
0.0027665691,
-0.05648164,
-0.009512767,
0.009466493,
0.009499546,
0.00030904924,
0.0011651322,
0.0076882197,
0.008897974,
0.013102366,
-0.050188277,
0.021193838,
-0.006442107,
-0.014371616,
0.02510736,
0.01090762,
-0.024671054,
0.009135959,
-0.0010196973,
-0.0108481245,
-0.0020608793,
0.027447538,
-0.015257447,
0.019646939,
0.0027797904,
0.006180985,
0.004739857,
0.013789876,
0.0049381773,
0.04051024,
0.026310503,
-0.010689468,
-0.0009122737,
-0.018417351,
0.011086109,
0.010537422,
0.010841514,
0.007893151,
-0.014318731,
0.018523123,
-0.012626397,
0.0031764312,
0.03252454,
0.023798445,
0.006690007,
0.0006755288,
0.010583697,
0.0055827186,
-0.018721443,
0.0052951537,
0.0064718546,
0.044265106,
-0.018853657,
-0.007245304,
-0.033132724,
0.0012618133,
-0.021934234,
-0.031308174,
0.012276031,
-0.021564035,
0.00093045307,
-0.015468989,
-0.017240651,
-0.0046010325,
0.02842592,
-0.009294615,
0.008679821,
-0.010577086,
0.002667409,
-0.018615672,
-0.0070337625,
-0.023494354,
-0.023877773,
-0.010193667,
0.0051265815,
0.0018592535,
0.0034243318,
-0.0030557865,
-0.009162401,
0.016143277,
-0.022978721,
0.024366964,
-0.021735912,
0.035195254,
0.02326959,
-0.006842053,
0.0031119771,
-0.0045812004,
-0.015535096,
0.01780917,
-0.029166317,
-0.010874567,
0.0015568149,
0.03329138,
-0.0076485556,
0.0044357656,
0.009644981,
0.04905124,
-0.01168768,
-0.012771832,
-0.0054438943,
-0.0041415906,
0.0034243318,
-0.008408784,
0.038130395,
0.0026855883,
0.005903336,
0.013155252,
-0.032762524,
0.06965011,
-0.00039767366,
-0.0077344943,
0.021273166,
0.007972479,
-0.035671223,
-0.13242513,
-0.03292118,
0.019157749,
-0.0004656397,
-0.009288004,
0.031678375,
0.005559581,
0.0019881618,
-0.003493744,
0.027394654,
-0.022846507,
-0.0065644043,
-0.0108216815,
-0.0042010867,
0.0033714464,
0.016381262,
0.034005333,
-0.0147947,
-0.0212335,
0.044767518,
-0.0016807652,
-0.0024128978,
-0.014517051,
0.01538966,
-0.0048224903,
0.0041382853,
-0.03717846,
0.0116281845,
-0.0036292628,
0.009089684,
0.024009986,
0.007417182,
0.014821142,
-0.0100151785,
-0.0134461215,
0.0003261957,
0.0011089414,
-0.017848833,
0.028452363,
-0.0041812547,
-0.010306048,
0.04505839,
0.022370538,
0.005430673,
0.0030706604,
-0.018959427,
-0.027368212,
0.014860806,
0.020585654,
-0.018747887,
-0.018033933,
-0.027817737,
-0.03419043,
-0.02317704,
0.014345174,
-0.01528389,
-0.0056289933,
0.03731067,
0.0045845057,
0.00720564,
-0.0008726096,
-0.013657663,
0.008342677,
0.021299608,
0.0063330303,
-0.014675708,
-0.009314447,
-0.02356046,
0.0317577,
-0.0052918484,
0.010775407,
-0.011257987,
-0.0030888398,
-0.008574051,
-0.020440219,
-0.013723769,
-0.0054571154,
0.007265136,
-0.0008701306,
-0.01956761,
-0.014450944,
-0.018576007,
0.022648185,
-0.013366793,
0.022529194,
0.0040060715,
0.0046208645,
-0.009512767,
0.006356168,
-0.012256199,
-0.019025534,
0.029298529,
-0.007807212,
-0.014133632,
-0.0078006014,
0.024975145,
0.0024128978,
-0.002391413,
0.018443795,
0.020651761,
-0.017901719,
-0.021154173,
-0.052938316,
0.026019633,
0.0059496113,
0.011429864,
0.03397889,
-0.008435226,
-0.0077146622,
-0.01684401,
0.008805425,
0.03350292,
-0.0018807382,
0.00051439344,
0.00050406426,
-0.0028359813,
-0.019580832,
-0.022555636,
0.020783976,
0.005361261,
-0.00052761484,
0.049712308,
-0.01430551,
-0.014477387,
0.007357686,
0.0044258498,
0.027685523,
-0.0010296133,
-0.012890824,
0.027288884,
-0.009400385,
-0.0241422,
0.031916358,
-0.038183283,
-0.018457016,
-0.0033598775,
-0.0006532177,
-0.005866978,
-0.014107189,
0.022846507,
0.01829836,
0.02617829,
-0.021484707,
-0.0212335,
0.015535096,
-0.013644442,
-0.0007941078,
0.0007482462,
-0.028293706,
-0.012818106,
-0.017240651,
0.024565283,
0.029615842,
0.006299977,
-0.022568857,
-0.0154557675,
0.00063503836,
-0.006756114,
0.012276031,
-0.0044027125,
-0.0352217,
-0.028187936,
0.0154557675,
0.008494723,
0.009512767,
0.0011453001,
-0.009274783,
-0.010557255,
-0.044053566,
-0.013373404,
0.011462918,
-0.043947794,
-0.036649603,
0.0021534287,
0.03572411,
0.0074237925,
0.020532768,
0.012315695,
-0.031308174,
-0.0022344096,
-0.00313842,
0.019210633,
0.008679821,
-0.008051807,
-0.025398228,
0.0008085687,
0.03620008,
-0.0057810387,
0.013604778,
0.026336946,
0.001946845,
0.005103444,
0.0077807694,
0.011945497,
0.008422005,
0.010841514,
0.008402173,
0.039267432,
0.0047266353,
0.007450235,
0.020070022,
0.035803437,
0.01936929,
-0.009069852,
-0.006220649,
-0.024565283,
0.0055033905,
0.025874197,
-0.02131283,
-0.05161618,
-0.022648185,
0.015984623,
0.019461839,
0.00564552,
0.017544743,
-0.012626397,
-0.029272087,
0.0052125202,
0.01430551,
-0.0094268285,
-0.008402173,
0.016500255,
0.011740566,
0.014556715,
-0.005890115,
0.00024211612,
0.0126396185,
-0.0092351185,
0.03146683,
-0.028002836,
0.032868296,
-0.012130596,
0.011205101,
0.006296672,
-0.025979968,
-0.008230295,
-0.015138455,
-0.0295894,
0.00749651,
-0.001821242,
-0.015958179,
0.09297259,
0.015958179,
-0.0075890594,
-0.013565114,
-0.0138427615,
0.017280314,
0.035195254,
0.02092941,
-0.033555806,
-0.03873858,
-0.011059666,
-0.010180445,
0.017491857,
-0.033079837,
-0.019461839,
0.00642558,
0.0154557675,
-0.0014973189,
0.010411819,
-0.013386625,
-0.0006156195,
-0.021286387,
-0.012573511,
0.0346664,
-0.02579487,
0.0028822562,
0.027183112,
0.016235828,
-0.0023798444,
-0.044344436,
0.010920842,
-0.013082534,
-0.04117131,
-0.003678843,
-0.0020079939,
-0.026270838,
-0.01927674,
-0.025662657,
0.00072139036,
0.024988366,
-0.007146144,
-0.01538966,
-0.010986948,
-0.05531816,
-0.012408244,
0.004088705,
-0.007185808,
-0.007245304,
-0.0071791974
] |
The subjective and behavioural responses of 20 healthy volunteers taking droperidol 5 mg as part of a cognitive challenge programme were catalogued. Some form of akathisia was universally experienced. Half of the subjects were dysphoric, but there appeared to be a number of different inputs to their dysphoria and a range of other effects were noted, including sedation, dissociative experiences, alterations in sensation and subtle changes in physiognomy. The duration of these effects varied from a few hours to over a week. In the acute phase, insight as to the origin of what was happening was mixed. The results have implications | [
-0.011599904,
0.006089787,
0.03139334,
-0.028006507,
-0.04051174,
0.025922302,
-0.022665732,
-0.02347336,
-0.013241216,
-0.018471269,
-0.013964174,
0.018718768,
0.0022975106,
0.008870898,
-0.0050248886,
0.019734817,
0.042674102,
-0.011248195,
0.008134914,
-0.0140944375,
0.002574319,
0.0003806117,
-0.009131424,
0.02372086,
-0.026573615,
0.00924866,
0.008167479,
-0.032878336,
0.0005845544,
0.00086217705,
0.009717607,
-0.023290992,
0.0139381215,
-0.00088904373,
-0.006119096,
0.0042954166,
-0.011801812,
-0.015279829,
0.011730167,
0.003989299,
0.013169571,
0.0019930212,
-0.014771804,
0.00022327862,
-0.0072295866,
0.011573852,
0.009821816,
-0.02372086,
0.005529657,
0.0117431935,
0.009678528,
0.02168876,
-0.0029748771,
-0.013781806,
0.031653866,
-0.021571523,
0.025127698,
-0.0016217722,
0.018093506,
-0.021245867,
-0.008773201,
-0.006721562,
-0.020229816,
0.009971619,
-0.024932304,
-0.008147939,
-0.018562453,
-0.0039241677,
-0.001815538,
-0.01028425,
0.021167709,
0.018445216,
-0.015826933,
0.008278202,
0.040589895,
-0.003927424,
-0.0007612234,
-0.0033347283,
0.011899509,
0.022431258,
0.0284494,
-0.015996274,
-0.024932304,
0.025049541,
0.021832049,
0.030663868,
-0.016973246,
0.020607578,
-0.015201671,
-0.0050835065,
-0.010818328,
0.027146772,
0.0142507525,
0.025414277,
-0.0006244474,
0.010082343,
0.0069886004,
0.018901136,
-0.036864378,
-0.021402182,
-0.025362171,
0.004647126,
-0.037229113,
-0.019383108,
-0.00327611,
-0.007301231,
-0.012674573,
-0.0047513363,
0.01569667,
-0.014237726,
-0.024515463,
0.027277036,
-0.0039371937,
-0.03313886,
-0.01979995,
-0.004161897,
-0.0010868805,
0.012199113,
0.017507324,
-0.03850569,
-0.0028153053,
0.030038606,
0.029882291,
-0.008864385,
0.0031067682,
0.0034910436,
0.008343333,
-0.0055622226,
-0.00044167237,
-0.0073207705,
0.0062167933,
0.016413115,
0.025948355,
-0.011912535,
-0.022535468,
0.014823909,
-0.016999299,
0.006581529,
-0.011215629,
-0.013508255,
0.0064284704,
0.006180971,
-0.0205685,
0.0032940211,
2.9417262e-7,
0.025179803,
0.02357757,
0.011997206,
-0.012804835,
-0.0027908809,
0.018510347,
-0.011892996,
-0.015983248,
0.015839959,
-0.01824982,
0.006021399,
0.019070476,
-0.011443589,
-0.017898113,
0.0059725503,
-0.019109556,
-0.025674801,
-0.004419166,
0.0024880199,
0.00870807,
0.006298207,
0.02662572,
-0.021167709,
0.0065717595,
-0.008245637,
-0.013755754,
0.046086986,
-0.025713881,
0.015397065,
0.01758548,
0.0039241677,
0.0055915317,
0.0060083726,
-0.013026282,
-0.0051909736,
-0.03696859,
0.009854383,
0.009027214,
0.029517556,
-0.0009484762,
-0.020034421,
0.026808089,
-0.007516165,
-0.004647126,
0.0092682,
-0.010818328,
0.0046178172,
-0.008955569,
-0.035900433,
-0.6490215,
-0.006347056,
0.007353336,
-0.02291323,
0.01737706,
0.014954172,
0.026456378,
0.036421485,
-0.0038688057,
0.015852986,
0.020399157,
0.009483133,
0.020685736,
-0.027172824,
-0.036421485,
0.013430097,
-0.013364965,
-0.014133516,
0.0068518245,
-0.0032598272,
-0.0002008897,
0.025844144,
-0.033790175,
0.0026589897,
0.018822977,
-0.022756916,
-0.012843914,
-0.006317747,
-0.009411489,
0.0503075,
0.0030123277,
0.028319137,
-0.0017227258,
0.02098534,
0.039573845,
-0.009698067,
-0.0038818321,
-0.012348915,
0.023890201,
0.053277493,
-0.021923233,
0.001363689,
0.030768078,
-0.001581065,
-0.0044842977,
0.007190508,
-0.00007011803,
-0.013729702,
0.023290992,
0.0028234466,
-0.00094033475,
-0.0026264242,
-0.0026931837,
0.004324726,
0.036421485,
0.0012122584,
0.0036017671,
-0.00009683209,
0.0025140725,
0.025700854,
0.0008857872,
-0.0014735982,
-0.011710628,
-0.0012407533,
-0.019357055,
0.015110487,
-0.00599209,
-0.0057283076,
-0.00034723183,
-0.017181667,
0.02372086,
0.033659913,
-0.014589436,
0.0015655963,
0.022235863,
0.0011251451,
0.017155614,
-0.0006403232,
-0.00972412,
-0.0017959987,
-0.0122577315,
-0.005643637,
-0.044133045,
0.011476154,
0.04288252,
-0.0015916489,
-0.011150498,
0.015631538,
-0.013013256,
-0.012622467,
0.00599209,
0.021350076,
0.009404976,
-0.022743888,
-0.027641771,
0.052469864,
-0.011078853,
0.008265176,
0.014524304,
-0.0040544304,
-0.013260756,
0.0020483828,
-0.0056762025,
0.01797627,
0.0038232137,
0.009411489,
-0.017324956,
0.0027534303,
0.045930672,
-0.009424515,
-0.001380786,
-0.0014003253,
-0.01072063,
-0.0063796216,
0.003196324,
-0.029204924,
0.016308906,
-0.0066368906,
0.0007657012,
-0.03962595,
0.00790044,
-0.002442428,
0.013221676,
0.01175622,
0.00046650373,
0.008447544,
-0.013286808,
-0.014758778,
-0.015162593,
-0.011678062,
-0.0058715967,
0.0051388685,
0.016334958,
-0.0018595018,
-0.009561291,
-0.010518723,
0.021923233,
-0.025062567,
-0.0006842869,
-0.036838327,
-0.029647818,
0.0023756681,
-0.007164455,
0.0037580824,
0.0019376595,
-0.034311228,
-0.018575478,
-0.0012301696,
0.0055068606,
-0.007919979,
-0.0053570587,
-0.018458242,
0.0059627807,
0.02554454,
-0.0009525469,
-0.010655499,
-0.003761339,
-0.020581527,
-0.013338913,
0.0005601301,
0.011625957,
-0.0013001858,
-0.011515234,
0.0016950449,
-0.04157989,
-0.0395999,
0.002665503,
0.01175622,
-0.00012161255,
-0.022014417,
0.008245637,
-0.011228655,
-0.005005349,
0.012414047,
0.0035887407,
0.016803904,
0.00013942193,
-0.00049459166,
-0.00009571265,
-0.011834377,
-0.0058813663,
0.009385436,
-0.016243774,
-0.0062135365,
0.034780174,
0.004692718,
0.023199808,
0.02123284,
0.009411489,
0.015826933,
0.02322586,
0.037828322,
-0.009339844,
-0.004025121,
-0.012922072,
0.0000472966,
0.05171434,
-0.0035366355,
0.0110267475,
0.039157003,
0.045227252,
0.007053732,
0.00293417,
0.0040218644,
0.018614557,
-0.009678528,
-0.007874387,
-0.008447544,
-0.0049760398,
0.01391207,
-0.014771804,
0.0010127934,
0.0020646658,
-0.0064121876,
-0.013084901,
0.021636656,
-0.006119096,
0.014941146,
-0.03178413,
-0.004113049,
0.0011096764,
-0.008388925,
0.04152779,
0.031836234,
0.0018220512,
0.015839959,
0.027928349,
0.020581527,
0.02670388,
-0.0037808784,
0.0042628506,
0.011769246,
0.011593391,
0.0019734818,
0.0074380073,
0.020451263,
-0.009476621,
-0.0075552436,
0.021675734,
0.02046429,
-0.01206885,
0.042934626,
0.03108071,
-0.019878106,
0.0010893228,
-0.007874387,
0.02224889,
-0.0027029535,
-0.01443312,
-0.013456149,
0.004025121,
-0.008747148,
-0.013137005,
-0.024749937,
-0.024437305,
-0.004279134,
0.0010421026,
0.02316073,
0.008701556,
0.028188875,
0.0069886004,
0.015983248,
0.033790175,
-0.013273781,
-0.003549662,
0.008760175,
-0.006610838,
0.007542217,
-0.007705046,
-0.019331003,
-0.004936961,
-0.0077376114,
0.0062363325,
-0.042309366,
0.034702014,
-0.0031425906,
-0.005712025,
0.008655964,
0.016517326,
0.0077832034,
-0.008662478,
-0.008369386,
0.0037417996,
0.023069546,
0.033764124,
-0.013260756,
-0.015631538,
0.010297276,
0.007398928,
0.025948355,
-0.0140944375,
0.016009301,
-0.004910908,
-0.0029927883,
-0.008121887,
-0.01706443,
0.02782414,
0.004057687,
0.0053244927,
-0.03058571,
-0.00024363218,
-0.0059855767,
-0.014420094,
-0.012642006,
0.011495694,
0.013925096,
-0.010942077,
-0.025661776,
-0.013469175,
0.012049311,
-0.014146542,
0.024163753,
-0.0124596385,
0.0009753429,
-0.016308906,
0.019552449,
-0.019812975,
0.003337985,
0.03517096,
-0.035978593,
-0.017090483,
-0.009046753,
-0.0113849705,
-0.026834141,
0.05322539,
0.008173992,
-0.005806465,
0.022170732,
0.017455218,
0.01053175,
-0.007190508,
-0.017689692,
0.027146772,
0.040120948,
-0.018588504,
-0.0131760845,
0.007288205,
0.007307744,
0.0007893113,
0.01986508,
0.013443124,
-0.008336821,
-0.0016649216,
-0.008988135,
0.010648985,
0.0021086293,
0.029830186,
0.027250983,
0.0008137356,
0.00040503597,
0.0091900425,
0.04288252,
0.0071839946,
-0.010916024,
-0.017429166,
0.0023137934,
-0.0015395437,
0.033790175,
-0.017702717,
-0.018666662,
0.0135343075,
0.024163753,
-0.00008227929,
0.0021884155,
0.0056468933,
-0.006558733,
0.000031369935,
-0.0067541273,
0.018419163,
0.004647126,
0.00028413578,
0.017298903,
0.0068583377,
0.004800185,
0.020386131,
-0.0052951835,
-0.003030239,
-0.01264852,
0.0068713636,
0.0031491036,
0.016895087,
-0.015214697,
-0.008121887,
-0.006154918,
-0.0004897068,
-0.028475452,
0.018171664,
-0.0090337265,
-0.022548495,
-0.031523604,
-0.006741101,
-0.01401628,
0.012381481,
0.006255872,
-0.0022747144,
-0.013755754,
-0.0054840646,
0.005028145,
0.020737842,
0.014941146,
0.0015476851,
-0.021558497,
0.021832049,
0.019018373,
-0.021675734,
-0.0037711086,
0.0012749473,
0.0025873452,
0.0167518,
0.025479408,
0.0021819023,
-0.015436145,
-0.010290763,
0.012355428,
-0.008043729,
-0.015397065,
-0.0028690386,
-0.020972313,
-0.008213071,
-0.009470107,
0.017351007,
0.031940445,
-0.013026282,
-0.021141656,
0.02774598,
-0.0221056,
-0.0030969987,
-0.00006543672,
0.007822283,
-0.019226793,
-0.020438237,
0.01391207,
-0.0020793204,
-0.026860194,
0.009926027,
-0.028762031,
-0.024554541,
0.0033933464,
0.037203062,
0.010759709,
0.0014605719,
0.029725976,
-0.009645962,
0.012987203,
-0.023486387,
-0.008844846,
0.013703649,
0.018601531,
-0.03647359,
0.022861125,
0.027303087,
0.0046145604,
-0.033790175,
0.0058129784,
-0.0059595243,
0.008180506,
-0.015501276,
-0.030924395,
-0.02280902,
0.016556405,
-0.013247729,
0.008532215,
0.010733657,
-0.019239819,
-0.01443312,
-0.0038557795,
-0.016556405,
-0.016829956,
0.027798086,
-0.026456378,
-0.023186782,
0.00015651892,
-0.04051174,
0.00044615017,
0.005783669,
-0.002899976,
-0.010121421,
-0.00005106201,
-0.005200743,
-0.042127,
-0.0031914392,
-0.006535937,
0.024958357,
0.022795994,
0.022548495,
0.019291924,
0.011866943,
0.016947193,
0.004256338,
0.013586412,
0.009411489,
-0.009965106,
-0.037541743,
0.034180965,
0.0036896945,
-0.0047969283,
0.007027679,
-0.00756827,
0.009489646,
0.051115133,
-0.01660851,
-0.015839959,
0.005571992,
-0.035692014,
-0.0042498247,
-0.0040511736,
-0.005034658,
-0.009984645,
-0.014133516,
0.011209115,
0.0076855063,
0.02270481,
0.0011080481,
-0.044471726,
0.021324024,
-0.02256152,
0.011222142,
0.010049777,
0.0004669108,
-0.0082716895,
-0.0007530819,
0.004468015,
-0.006060478,
0.0055817617,
0.005177947,
0.019070476,
-0.00093870645,
0.013508255,
-0.041814364,
-0.010792275,
-0.0041260747,
0.004865316,
-0.033685967,
-0.021506391,
-0.008864385,
0.0092356345,
-0.016321931,
-0.036812272,
-0.014602462,
0.0210635,
-0.015279829,
0.029100714,
-0.025935328,
-0.0182889,
-0.0030172125,
-0.020451263,
0.01793719,
-0.006721562,
0.027980454,
0.008675504,
-0.01119609,
-0.008323794,
0.0038329836,
0.0040283776,
-0.0014980225,
0.027120719,
0.026808089,
-0.0077832034,
0.002751802,
0.000002650734,
0.008154453,
-0.03535333,
-0.040902525,
-0.002185159,
0.0110528,
0.0007775062,
0.011411023,
0.019617582,
-0.026482431,
0.030507553,
-0.004370318,
-0.0022958822,
0.010342868,
0.0027192363,
-0.021558497,
0.011065827,
-0.0025043027,
0.0051356116,
-0.0129741775,
0.0076529407,
-0.02224889,
0.02361665,
-0.046060935,
0.022379152,
0.001518376,
0.020373106,
-0.010922537,
-0.00035720508,
0.015709696,
0.01604838,
0.008988135,
0.012453126,
-0.030455448,
0.03696859,
-0.008369386,
-0.015931142,
0.008903464,
-0.027772034,
0.016035354,
-0.02077692,
-0.016243774,
-0.015006277,
-0.0009525469,
0.018236795,
0.015826933,
0.007946032,
-0.011873456,
-0.009528725,
-0.020229816,
-0.024958357,
0.01808048,
-0.013560359,
0.016986271,
-0.040642,
0.003458478,
-0.019852053,
-0.0050769933,
0.029934397,
-0.0073924153,
0.013045821,
0.038635954,
0.008857871,
-0.014341936,
0.0042954166,
0.020972313,
0.025531514,
-0.031367287,
0.016934168,
-0.013521281,
-0.008597346,
-0.0006557919,
0.008838332,
-0.026755983,
-0.022144679,
0.0009549893,
0.011300299,
0.00047383102,
0.0050769933,
0.0002945161,
-0.014315884,
-0.012049311,
0.0057217944,
-0.05017724,
-0.008473597,
-0.03832332,
0.0071253763,
-0.00028067568,
0.00052756444,
-0.013032795,
-0.03634333,
0.02975203,
0.00071725965,
-0.0289444,
0.011117931,
0.00018104496,
0.0024798785,
-0.038453586,
-0.0011992321,
-0.0144722,
-0.014459173,
-0.02403349,
0.055856697,
0.00028800295,
-0.0073598493,
-0.027641771,
-0.006233076,
0.00020261975,
0.00891649,
0.017390087,
-0.016621536,
0.0041912063,
-0.029335188,
-0.0472333,
-0.00937241,
-0.0073142573,
0.0360828,
0.03118492,
-0.011580365,
-0.010030237,
-0.018210743,
-0.041319367,
0.00021249123,
0.012049311,
0.009014187,
0.02063363,
0.026287038,
-0.0028267032,
-0.0039795293,
0.004139101,
0.012811349,
-0.037124906,
-0.010857406,
0.024111649,
-0.024111649,
0.033269126,
-0.005920445,
-0.04968224,
0.003715747,
0.004562455,
-0.028423348,
-0.01163247,
0.007385902,
-0.000118763055,
-0.011078853,
-0.023382176,
0.0032240048,
0.008284715,
0.0061679445,
-0.018119559,
-0.011456615,
0.012928585,
-0.010030237,
0.017689692,
-0.0091900425,
0.0011373572,
0.026091643,
-0.0035626881,
0.01737706,
-0.038792267,
-0.029022556,
0.0016470106,
-0.037046745,
0.011801812,
0.020516394,
-0.004731797,
0.00924866,
-0.007060245,
0.006298207,
-0.012804835,
0.015071409,
-0.0065033715,
-0.012642006,
0.013964174,
-0.0010917652,
0.016139563,
0.017259823,
0.0004428936,
-0.017285876,
0.024593621,
-0.019239819,
-0.0015509417,
-0.013071874,
0.006376365,
0.0106229335,
-0.013364965,
-0.0039013715,
0.009926027,
-0.0048783426,
0.0012521513,
-0.027277036,
0.019109556,
-0.03423307,
-0.0031328208,
0.0021835305,
-0.01930495,
0.027511507,
0.004722027,
0.008506162,
-0.025661776,
0.006376365,
0.17830375,
0.004067457,
0.008642938,
0.011977666,
0.005164921,
-0.0050639673,
0.019396134,
-0.012583389,
-0.015996274,
0.02305652,
0.03423307,
-0.014029305,
-0.024606647,
-0.0016445682,
-0.0042856466,
-0.010753196,
-0.0049695265,
0.00066678284,
0.0105122095,
-0.01503233,
0.0023203066,
-0.020607578,
-0.00721656,
0.0019571988,
0.036838327,
-0.0033640373,
-0.009678528,
-0.031419393,
0.02017771,
0.016842984,
-0.013065361,
-0.026612695,
0.013586412,
0.007333797,
0.004373574,
-0.008011163,
-0.009632936,
-0.03363386,
0.0085191885,
0.0019490574,
0.007874387,
-0.0020158172,
-0.018523373,
0.00046853907,
0.00071481726,
0.0162568,
0.008838332,
-0.013182597,
0.010407999,
-0.008558268,
-0.03441544,
-0.010733657,
0.016973246,
0.005050941,
-0.013742727,
-0.0016901601,
0.014498252,
0.005285414,
-0.011397997,
0.015605486,
-0.0060702474,
0.009873922,
-0.002865782,
0.024463357,
-0.026234932,
0.023851123,
-0.012700625,
-0.0047285403,
0.0022454055,
-0.005497091,
0.014849962,
-0.017507324,
-0.035796225,
0.0092356345,
-0.004601534,
-0.018914161,
-0.0018546169,
0.044289358,
0.0062851813,
0.024333095,
-0.004412653,
-0.0050151185,
-0.0032842513,
-0.0047643627,
-0.032982547,
-0.012277271,
0.024749937,
0.005975807,
-0.0370728,
0.0045461725,
-0.026586642,
-0.02732914,
-0.0021428233,
-0.004041404,
0.010994182,
-0.0056827157,
0.027798086,
0.02448941,
-0.004412653,
-0.01086392,
-0.013202137,
0.07039403,
-0.0025531512,
0.018419163,
-0.014928119,
0.0016022327,
-0.025192829,
-0.0027534303,
0.0002945161,
-0.02270481,
0.013703649,
-0.02627401,
0.023082571,
-0.016022326,
0.014029305,
0.037255168,
-0.00038895666,
-0.015644565,
0.013228189,
-0.009229121,
0.0029357984,
-0.025531514,
-0.0056306105,
0.010336355,
0.00107304,
0.0012057453,
-0.02088113,
-0.007750638,
0.008278202,
-0.03178413,
0.015879039,
-0.019773897,
0.004490811,
0.0023365894,
-0.02515375,
-0.012694112,
-0.0011308441,
-0.0049402174,
-0.011873456,
-0.008662478,
0.0053896243,
-0.010082343,
0.025687829,
0.01331286,
0.0021607345,
-0.018341005,
-0.0011349148,
0.014394042,
-0.025518486,
0.0063893916,
-0.020659683,
-0.009502673,
0.0073142573,
-0.006037682,
0.018862057,
-0.017859032,
-0.014980225,
-0.009606883,
-0.008682017,
0.011919049,
-0.050515924,
0.0040088384,
0.007946032,
0.011645496,
-0.0017227258,
0.009222608,
-0.16288063,
0.011919049,
0.011124445,
-0.016647588,
0.013234703,
-0.0022470336,
0.024072569,
-0.0043410086,
-0.030012554,
-0.015826933,
0.023994412,
-0.005360315,
-0.030038606,
-0.039756212,
0.024098622,
-0.008610372,
-0.015970223,
0.008428005,
0.016439168,
0.014315884,
0.014068385,
-0.018236795,
0.014367989,
-0.0068062325,
0.009574317,
0.019226793,
-0.013651543,
0.021167709,
-0.0010746683,
-0.0057217944,
-0.01832798,
-0.0010307046,
0.03402465,
0.009730632,
0.0085647805,
0.0073663625,
-0.0029879035,
-0.02732914,
-0.008063269,
0.023799017,
0.023603624,
0.025622698,
-0.0072035342,
0.008291229,
-0.0103103025,
0.024867173,
0.015605486,
0.0053440323,
-0.024854146,
-0.0038850887,
0.007998137,
-0.010108395,
0.0037515692,
0.00028617113,
0.016673641,
0.014446147,
0.042960677,
0.008844846,
0.0012708766,
-0.019291924,
-0.010460105,
-0.02326494,
0.01741614,
0.0033705505,
0.012446613,
-0.010212605,
0.0015493134,
-0.01580088,
-0.006702022,
0.0014076526,
-0.029335188,
0.015357987,
-0.0028397294,
0.012635494,
0.006467549,
0.025622698,
-0.009333331,
-0.0002277564,
0.004549429,
-0.00077954156,
-0.0073468233,
0.024919277,
-0.04676435,
-0.009658989,
-0.01839311,
0.0014703416,
0.007281692,
0.027355192,
0.0151235135,
-0.0024407997,
0.0050672237,
-0.011274247,
0.007451033,
0.009489646,
-0.015475223,
0.018809952,
0.0038134442,
0.009118398,
0.014276805,
-0.0180414,
0.026834141,
-0.0041195615,
-0.0014166082,
0.0017178409,
0.011463128,
-0.000770586,
-0.028788084,
0.015045356,
0.0016632935,
-0.009880435,
-0.024007438,
0.0049011386,
0.0101605,
0.014732725,
-0.0039111413,
0.041996732,
0.009619909,
-0.00024281805,
0.008616886,
-0.009098858,
0.07221771,
-0.015110487,
-0.024554541,
-0.011671549,
-0.012309836,
-0.013404044,
-0.13140914,
-0.025362171,
0.011938588,
-0.0075878096,
0.019812975,
0.006741101,
0.013573386,
0.025179803,
0.0021705043,
0.00078279816,
0.0026475918,
-0.012889506,
0.013078387,
-0.022743888,
0.017481271,
0.007379389,
0.04085042,
-0.021845074,
0.004572225,
0.034259122,
-0.014485226,
-0.0017666895,
0.0013172828,
-0.010381947,
-0.002797394,
0.0009012559,
-0.012524771,
0.02301744,
0.0056240973,
0.029830186,
0.020542447,
-0.00756827,
0.009359384,
0.0015232608,
-0.015970223,
0.0006081645,
-0.019422187,
-0.032331232,
0.041788314,
-0.02025587,
0.009619909,
0.008577807,
-0.008167479,
0.0073142573,
0.015488249,
0.00086624775,
-0.014758778,
-0.0012977434,
0.024723884,
0.0025108159,
-0.026404275,
-0.036890432,
-0.0069430084,
-0.018145612,
0.029543608,
0.015774827,
0.027954401,
0.008662478,
-0.04358594,
0.0034910436,
-0.017494297,
-0.0045917644,
-0.007242613,
0.0012358685,
0.011254707,
-0.013137005,
-0.031106763,
-0.011977666,
0.01264852,
-0.0077180723,
-0.014862988,
0.0015444285,
-0.010603393,
0.007854848,
-0.03444149,
0.021714812,
-0.00968504,
-0.015449171,
-0.0032923927,
-0.00022287155,
-0.0142247,
0.0051909736,
0.016960219,
-0.01387299,
0.026352169,
0.0182889,
0.019265871,
0.0017438935,
-0.003373807,
-0.0020109322,
-0.03829727,
0.00032626765,
-0.015149566,
-0.008434517,
-0.0031181662,
-0.0060800174,
0.0153710125,
-0.016947193,
0.01049267,
0.026000459,
-0.0026589897,
-0.00982833,
-0.020542447,
-0.013729702,
0.009359384,
-0.013137005,
-0.00018867756,
0.005376598,
0.028397296,
0.010929051,
-0.0122577315,
-0.009939053,
-0.015084434,
-0.019982317,
-0.013729702,
0.0007779133,
-0.040068842,
-0.029908344,
0.01119609,
0.0051063024,
0.005011862,
0.016074432,
-0.024880199,
-0.0005483251,
-0.0013897414,
0.026130723,
-0.034050703,
0.012485691,
-0.020607578,
-0.007424981,
-0.0008296113,
-0.00082269113,
0.0167518,
-0.00688439,
0.0060474514,
0.00004447254,
-0.007874387,
0.014537331,
0.011580365,
0.034962542,
0.0020728072,
0.039860424,
-0.029882291,
-0.020190738,
0.01793719,
-0.04134542,
-0.0036896945,
-0.0029976731,
-0.032122813,
0.0053114668,
-0.0017243541,
0.0011373572,
0.020802973,
0.017963244,
-0.0103103025,
-0.022952309,
-0.016556405,
-0.012218652,
-0.004800185,
-0.014889041,
-0.016022326,
0.008187018,
-0.007913467,
-0.026052564,
0.007802743,
-0.016504299,
0.0039013715,
0.0142507525,
-0.03920911,
-0.02627401,
0.028397296,
0.00226006,
-0.01913561,
0.0056273537,
0.020490343,
0.009717607,
0.022431258,
0.010427539,
0.0006712606,
0.03293044,
-0.018171664,
0.001592463,
0.02291323,
0.008173992,
-0.032435443,
0.00025991505,
0.0008385669,
0.023277966,
-0.02280902,
0.029621765,
0.0063959043,
0.01320865,
-0.0009623166,
-0.0035529186,
-0.0007367991,
0.008903464,
-0.00009011541,
0.031679917,
-0.008121887,
-0.021506391,
0.021206787,
0.020190738,
0.008258663,
0.013833912,
-0.0067997193,
-0.03874016,
-0.012498718,
-0.0053244927,
-0.03412886,
-0.031237025,
0.0037808784,
-0.0056273537,
0.0018253077,
0.0016624792,
0.0037515692,
0.023864148,
-0.024437305,
-0.007861361,
0.020021396,
-0.0069951136,
0.008037216,
0.045201197,
-0.014889041,
0.022795994,
0.007887414,
0.0013205394,
0.026586642,
-0.02357757,
0.034519646,
-0.010043263,
0.01681693,
-0.0032956493,
0.0065685026,
-0.023277966,
-0.03475412,
0.008154453,
0.0024261451,
-0.037229113,
0.013781806,
0.012759243,
-0.0009525469,
0.06471457,
0.033477545,
-0.0021819023,
0.004559199,
-0.015618512,
-0.0050541973,
-0.005458012,
0.024098622,
-0.0105122095,
-0.007620375,
0.026677826,
-0.017181667,
0.046660144,
-0.032591756,
-0.009756685,
-0.011000696,
0.009444054,
0.013547334,
0.02722493,
-0.014042332,
0.017311929,
-0.014628515,
0.006936495,
-0.0053407755,
-0.01706443,
-0.01832798,
0.03423307,
-0.020529421,
-0.019526398,
-0.034493595,
0.003070946,
0.021740865,
-0.039860424,
-0.02218376,
-0.008134914,
-0.014029305,
0.012707138,
-0.0037092338,
-0.0012049311,
-0.0063079773,
-0.012003719,
0.03618701,
-0.019852053,
-0.0003692137,
-0.02693835,
-0.026495459,
0.0017569198,
0.0038492663,
-0.019578502
] |
The toxic effects of Nerium oleander were evaluated in capuchin monkeys (Cebus apella) by examination of clinical signs, hematologic and serum chemical values, and gross and microscopic lesions. Dried and ground oleander leaves were given at intervals of 48 h in doses of 30, 7.5, and 3 mg/kg body weight. The cumulative lethal dose ranged from 30 to 60 mg/kg body weight in monkeys that were given doses of 30 and 7.5 mg/kg body weight. Monkeys that received doses of 3 mg/kg body weight (total cumulative dose: 60 | [
0.0040984983,
-0.008889885,
-0.0030689712,
-0.029310472,
-0.0057882303,
0.02622516,
-0.00972658,
0.008118557,
-0.020420589,
0.011014306,
-0.0010229904,
0.0127596,
0.0045887493,
-0.0013302144,
-0.016433213,
0.024983192,
0.037965037,
-0.004608359,
-0.0033189992,
0.011641827,
-0.010504445,
0.00964814,
-0.02334902,
-0.0053764195,
0.02096967,
-0.0042259637,
0.011929441,
-0.046175107,
0.0033631218,
-0.017256835,
0.005909159,
0.0013351169,
0.0064941915,
-0.00091595226,
-0.01130192,
0.010844352,
0.012184371,
-0.0023564731,
0.0051280255,
0.014851337,
0.0062261876,
0.02069513,
0.004971145,
-0.010282198,
-0.018341925,
0.008981398,
-0.0074452786,
-0.027610937,
-0.00805319,
0.02941506,
0.013243314,
0.0111385025,
0.019309353,
0.013883908,
0.0004526651,
-0.0061346744,
0.016472433,
0.024917824,
0.04248842,
0.004641043,
-0.004026595,
0.013818542,
-0.026525848,
0.011792171,
-0.026042134,
0.002490475,
0.009700433,
0.010759375,
-0.018472658,
-0.0041279136,
0.03291872,
0.02750635,
-0.0065039964,
-0.005363346,
0.011955588,
0.015491932,
-0.030905424,
0.0076936726,
0.013413267,
-0.011648363,
0.04057971,
-0.026904974,
-0.042462274,
0.011569924,
0.03093157,
-0.00066674134,
0.0041377186,
-0.0038893246,
0.038670998,
-0.007719819,
-0.000039143477,
0.005222807,
-0.0014576797,
-0.010602495,
-0.006268676,
0.010955475,
-0.007236105,
0.023492828,
-0.024917824,
-0.021571044,
-0.024238009,
-0.013557075,
0.00017608181,
-0.0046671894,
-0.028133871,
-0.0028957492,
0.010439078,
-0.00012623964,
0.016590094,
-0.016773121,
-0.014419916,
0.033572387,
0.010269124,
-0.029153593,
-0.026538922,
-0.020943522,
0.03242193,
0.019910727,
-0.010367175,
0.0027699182,
0.005758815,
0.0065987785,
0.033520095,
-0.020015314,
0.012236665,
0.020093754,
0.021348797,
-0.034173764,
-0.031454504,
0.006392873,
0.023597416,
0.015609592,
0.028447632,
-0.0043305503,
-0.013700881,
0.032657254,
-0.014498357,
-0.006213114,
-0.010903182,
-0.023623561,
0.0113803595,
0.017204542,
-0.005722863,
-0.000562563,
-0.009079449,
0.03252652,
0.016446287,
0.03260496,
0.004768508,
-0.014341476,
-0.0018874664,
-0.020420589,
0.027061855,
-0.022342373,
0.0152958315,
0.0017567327,
0.014380696,
0.023584342,
-0.03618706,
0.01017761,
0.0008718297,
-0.01482519,
-0.012530816,
0.006200041,
0.013243314,
0.022695353,
0.008844128,
-0.010190684,
0.013040677,
-0.0060137454,
-0.01852495,
0.02439489,
0.010373712,
0.04120723,
0.012615792,
0.007745966,
0.011524167,
-0.006533412,
0.0047358247,
-0.022773793,
-0.020721275,
0.03908935,
-0.0044351374,
0.003882788,
-0.007190348,
-0.006209846,
0.008085873,
0.011916367,
0.0023188873,
-0.0033108285,
-0.014537577,
-0.0025525736,
-0.032814134,
-0.026120573,
-0.6467653,
-0.0060529658,
-0.012615792,
0.015531152,
0.00984424,
0.0056574964,
0.019832287,
-0.01000112,
-0.018041236,
0.017165322,
0.015426565,
0.008974861,
0.0261075,
-0.01988458,
0.009523943,
-0.015635738,
-0.019518526,
-0.022028612,
0.0068569775,
-0.0040690834,
-0.039664574,
-0.0029839943,
-0.009138279,
0.008530367,
-0.01813275,
-0.005353541,
0.001884198,
-0.020420589,
-0.009602383,
0.042540714,
0.009353989,
0.021283431,
0.0143284025,
0.017191468,
0.043952636,
-0.026800388,
-0.01852495,
0.015949499,
0.004091962,
0.027088001,
-0.023100628,
0.019557746,
0.017805917,
-0.019596966,
-0.034984313,
-0.0028990177,
0.021427236,
-0.02104811,
-0.005536568,
-0.0047129462,
0.029519647,
0.0037716643,
0.0028271142,
-0.015465785,
-0.001000112,
0.0035396123,
0.019230913,
-0.00994229,
0.013452487,
0.00033847746,
0.0012133712,
-0.023165993,
-0.018629538,
-0.015243538,
-0.0140669355,
0.0073406915,
-0.024957044,
0.028055431,
0.009798483,
-0.026473554,
0.04520768,
0.014406843,
-0.008118557,
0.0053894925,
0.021427236,
0.013027604,
-0.0053404677,
-0.028996713,
-0.015975647,
0.031532943,
0.009118669,
-0.00041017667,
-0.023231361,
0.015936425,
0.00803358,
-0.02419879,
-0.0018923689,
0.012243202,
0.009066375,
-0.03046093,
0.023715075,
0.02415957,
-0.005304516,
-0.026094427,
-0.002394059,
-0.00019334274,
-0.0031604848,
0.008125093,
-0.022773793,
-0.020407515,
-0.018381145,
-0.018498804,
-0.009896534,
-0.025192365,
0.014890557,
0.012380472,
-0.021178843,
0.019858435,
0.04808382,
-0.00014115144,
-0.0025068168,
0.015165098,
-0.005056122,
-0.0059222323,
0.0070007844,
-0.012269349,
-0.0060921856,
-0.008079337,
-0.0101645375,
-0.03459211,
0.012772673,
0.020564396,
0.031349916,
0.017191468,
0.017479083,
-0.01626326,
0.0045299195,
-0.01622404,
-0.0091774985,
-0.037598982,
0.011857538,
0.012256275,
-0.005095342,
-0.008438854,
0.018825639,
0.014393769,
0.024617137,
-0.019283205,
0.019427013,
-0.034853578,
-0.02408113,
0.01649858,
0.0072034216,
-0.0036343941,
0.0010205392,
-0.028316898,
0.01019722,
0.018315777,
-0.011935977,
-0.011190796,
0.0028859442,
-0.015361198,
-0.0011234919,
0.0135832215,
0.018224264,
-0.0024054982,
-0.007432205,
-0.022250859,
-0.008791835,
-0.0019757114,
0.026708875,
-0.0024724992,
-0.03077469,
0.008314657,
-0.026643507,
-0.024996264,
0.018969445,
0.015609592,
-0.007602159,
-0.04120723,
-0.027375616,
-0.031376064,
0.0012918113,
0.012733453,
-0.013936202,
0.0034644403,
-0.023623561,
-0.027610937,
-0.012511206,
0.010916255,
0.021074256,
0.015374271,
0.0070726876,
0.0038991296,
0.033467803,
0.0056280815,
0.017635962,
0.03691917,
-0.007981286,
0.028264605,
0.0028238457,
0.010144928,
-0.008425781,
0.0048992415,
0.011504557,
-0.01466831,
0.009948827,
-0.008497684,
0.016720828,
0.035271924,
0.028081577,
-0.019505452,
0.022747647,
-0.017492156,
0.0028107725,
0.016877707,
0.0017224152,
-0.008974861,
0.031036157,
0.0037128343,
0.016877707,
0.035088897,
-0.031114597,
-0.012792283,
-0.021335723,
0.016825415,
0.018276557,
-0.017845137,
0.007092298,
-0.011752951,
0.016080232,
-0.016093306,
0.01789743,
0.0040527415,
-0.0035036604,
0.016590094,
0.022734573,
0.020381369,
-0.004072352,
-0.0049874866,
-0.0138316145,
-0.0060300874,
0.00962853,
-0.010347565,
0.02120499,
-0.011929441,
0.0003139649,
-0.030957717,
0.024146495,
0.00021489336,
-0.002325424,
0.03242193,
0.036788434,
-0.0022453496,
0.02559764,
-0.00022163431,
0.008863738,
0.010053414,
0.013674734,
0.0044972356,
0.007850553,
-0.010426004,
-0.016433213,
-0.011432653,
0.0050757322,
0.0035821006,
0.010576348,
0.028003138,
0.020316001,
0.01657702,
0.028264605,
-0.01642014,
0.027375616,
-0.01482519,
0.010595959,
-0.01149802,
-0.013779322,
0.019374719,
0.020198341,
-0.026185941,
-0.0015148756,
-0.012092858,
0.005219539,
0.001403752,
0.0018041236,
0.022760719,
0.0052456856,
-0.0015565469,
0.028892126,
0.0064059463,
-0.025806813,
-0.015387345,
-0.0006124052,
0.0044057225,
0.0024708651,
-0.0019103447,
-0.020904303,
-0.012288959,
0.012792283,
0.039167788,
0.009001008,
0.018864859,
0.00025819885,
0.030147169,
-0.017962797,
-0.03116689,
0.00034358425,
-0.0163417,
0.004180207,
-0.01801509,
-0.004650848,
-0.008059726,
-0.006487655,
0.000020171787,
0.0052979793,
0.011275773,
-0.010275661,
-0.0128445765,
0.0018809297,
0.023911176,
0.00067654636,
-0.0051639774,
-0.0053241258,
-0.0033206334,
-0.0121059315,
0.02069513,
0.00061281375,
0.0027159906,
0.0263036,
-0.007517182,
0.00067899766,
-0.023767369,
-0.01797587,
-0.0037030291,
0.027297176,
0.018629538,
0.0026800388,
0.008353877,
0.015635738,
-0.009504333,
0.000053365864,
-0.020577468,
0.000163417,
0.010491371,
-0.012726916,
-0.021571044,
0.012047101,
0.0046475795,
0.011883684,
-0.012583109,
-0.012792283,
-0.042357687,
0.0061575524,
-0.009955363,
0.0029447745,
-0.008863738,
0.021897878,
0.026721949,
0.0034971237,
0.014955924,
0.0043991855,
0.03155909,
0.002325424,
0.011484947,
0.008046653,
-0.00020999085,
0.0010221733,
0.016380921,
-0.049783356,
-0.013289071,
-0.007085761,
0.019505452,
0.027872404,
-0.014890557,
0.010125318,
0.016760048,
-0.01785821,
0.005304516,
0.003644199,
-0.00998151,
-0.0023826198,
0.022355447,
-0.0111254295,
0.000317029,
0.031820558,
-0.0020034923,
-0.00057073386,
-0.012328179,
0.01153724,
0.0044743577,
-0.00027147649,
-0.018721052,
-0.010099171,
0.0059483787,
-0.0022224712,
-0.028003138,
0.026395114,
-0.0049515353,
-0.026355894,
-0.0032242173,
-0.035821006,
-0.004520114,
-0.028970566,
-0.012413155,
-0.0041867434,
-0.0019675407,
-0.009974973,
0.020342149,
0.029937994,
0.015204318,
0.013413267,
-0.027166443,
0.008295047,
0.01139997,
0.009164426,
0.010602495,
-0.031219184,
-0.023518974,
0.024224937,
0.047456298,
0.0050495854,
-0.0029741894,
-0.015348124,
-0.010073024,
0.006863514,
-0.008929105,
0.009072912,
0.0038206894,
-0.012302032,
-0.021858659,
0.0089225685,
0.011792171,
0.014001569,
-0.018851785,
0.030670103,
-0.008595734,
-0.010922792,
-0.021897878,
-0.012733453,
-0.0030346536,
-0.0118640745,
0.009092522,
-0.015178171,
0.0026963805,
0.018590318,
-0.00803358,
0.00805319,
0.008674175,
0.009452039,
0.0014004837,
-0.013753175,
0.019989168,
0.013674734,
-0.02638204,
0.0121124685,
-0.023126774,
0.047560886,
0.010962012,
-0.0030591663,
0.026904974,
-0.01618482,
0.0048338748,
-0.012210518,
0.0069158073,
0.023780443,
0.010870499,
0.004239037,
-0.022969894,
-0.029676527,
-0.022394666,
-0.036526967,
0.000116843155,
-0.008536904,
-0.0197277,
-0.017635962,
-0.001844978,
-0.0009755995,
-0.010014194,
0.032265052,
-0.017191468,
-0.008255827,
0.0026359162,
-0.0033860002,
-0.01642014,
-0.03302331,
0.011184259,
-0.020995816,
0.008007433,
-0.017792843,
0.011883684,
-0.0064157513,
0.015570371,
0.039403107,
0.0025558418,
0.040161364,
-0.023479754,
0.035821006,
-0.0016031208,
-0.026826534,
0.007595622,
-0.011014306,
-0.0074648885,
-0.031898998,
0.0152958315,
0.00964814,
0.024133423,
-0.0041409866,
-0.012465449,
0.008961788,
0.024682503,
-0.0017550986,
-0.029179739,
-0.0108901085,
-0.019243985,
-0.009706969,
0.023610488,
-0.012622329,
0.026055207,
0.008706857,
-0.007576012,
0.04290677,
0.02902286,
-0.009092522,
-0.021688703,
0.011844465,
-0.013308681,
0.0068112207,
-0.018877933,
-0.0048861685,
0.011190796,
-0.0015745228,
0.0077067455,
-0.013936202,
-0.026617361,
-0.020132974,
-0.010242977,
0.017322201,
-0.0033892686,
-0.018119678,
0.00081463373,
0.016446287,
-0.0035886373,
-0.029598087,
-0.009870387,
-0.01878642,
0.013727028,
-0.005327394,
-0.018681832,
-0.0052260756,
0.0057359366,
-0.0072426414,
0.018185044,
-0.03221276,
-0.011151576,
0.018433437,
-0.014694457,
0.024329523,
-0.027924698,
0.026682727,
0.01669468,
-0.007236105,
-0.018773345,
0.02144031,
-0.0030281171,
0.0039350814,
0.011824854,
0.040318243,
-0.033546243,
0.008889885,
0.014093082,
0.012471985,
-0.01482519,
-0.021950172,
0.035690274,
0.02039444,
-0.0075890855,
-0.0130995065,
-0.0057980353,
-0.041076496,
0.027166443,
-0.003382732,
-0.00037626765,
0.002902286,
-0.006824294,
-0.026551994,
0.032238904,
0.0030918496,
0.011929441,
-0.0040886933,
0.003797811,
-0.024538698,
-0.02419879,
-0.017635962,
0.0017926845,
-0.011785634,
0.028238459,
0.0123673985,
-0.01147841,
-0.02368893,
-0.005941842,
-0.013308681,
-0.0032078756,
-0.0038239579,
0.033781562,
-0.0014936314,
0.008634955,
0.016760048,
0.0026587946,
-0.00023225641,
-0.007438742,
-0.02112655,
-0.016093306,
-0.009210182,
-0.0050822687,
0.0024463525,
0.02221164,
-0.017086882,
0.0099030705,
-0.026957268,
-0.007660989,
-0.023662781,
-0.046462722,
0.0065628267,
-0.03085313,
-0.002980726,
-0.008961788,
-0.004699873,
0.03532422,
0.0064582396,
-0.02295682,
0.024734797,
0.012877259,
-0.0045233825,
0.017492156,
0.0019544673,
0.020551322,
-0.029571941,
0.01108621,
-0.019348573,
-0.040056776,
0.011001232,
-0.02677424,
-0.06604662,
-0.012524279,
-0.020263707,
0.0061967727,
-0.0029088226,
-0.020446735,
0.03459211,
-0.03453982,
0.0255192,
-0.015531152,
0.0013686174,
0.019753847,
-0.023858882,
-0.013517855,
0.018224264,
-0.013740102,
-0.022551546,
-0.022002464,
0.005144367,
0.007151128,
0.006843904,
0.016668534,
-0.010582885,
0.018538024,
-0.013478634,
-0.027610937,
-0.02069513,
-0.014093082,
-0.025153145,
0.028316898,
-0.017217616,
-0.03299716,
-0.0051378305,
-0.011164649,
0.00009039003,
-0.008393097,
0.006961564,
0.016916929,
0.001384142,
-0.02435567,
-0.033049453,
-0.01793665,
-0.02299604,
0.04003063,
0.0070988345,
-0.0012509571,
-0.021793291,
-0.03053937,
-0.03461826,
-0.006700097,
-0.03524578,
0.015178171,
-0.015583445,
0.019871507,
-0.0034056103,
0.01297531,
-0.0084323175,
0.0128511125,
-0.028892126,
-0.020891229,
0.009870387,
-0.012864186,
0.04120723,
-0.022656133,
-0.02400269,
0.0013293973,
0.019243985,
-0.0014168253,
-0.039638426,
0.016590094,
-0.0069158073,
-0.009334379,
-0.03453982,
0.008451927,
0.018028164,
0.0012942626,
0.0077132825,
-0.007275325,
0.00061281375,
-0.017439863,
0.017792843,
-0.0031081913,
-0.0018171971,
0.03318019,
0.008157777,
0.0057457415,
-0.013439414,
0.00088653725,
-0.016838487,
-0.00805319,
0.0006904368,
0.011746414,
-0.02108733,
0.017086882,
0.0011529069,
0.003863178,
-0.00960892,
0.0000015463972,
-0.015936425,
0.004775045,
0.0057326686,
-0.0058503286,
0.0073668384,
-0.020093754,
0.020708201,
-0.027401762,
0.0225254,
-0.0074452786,
-0.008412708,
-0.008059726,
0.031036157,
0.023192141,
-0.027166443,
0.0130864335,
0.016041012,
0.010556738,
-0.009850777,
-0.028499926,
0.010380248,
-0.030670103,
-0.017426789,
-0.0060300874,
-0.015505005,
-0.020302929,
-0.019989168,
-0.025754519,
-0.035611834,
0.015805691,
0.1681757,
-0.0043959175,
0.0034938555,
0.032944866,
-0.01957082,
0.003134338,
0.013478634,
0.01968848,
-0.0048534847,
0.016197894,
0.020904303,
-0.012387008,
-0.013792395,
0.008013969,
0.011151576,
0.00964814,
-0.021571044,
-0.014197669,
-0.010118781,
-0.000027397882,
0.0015581811,
-0.005660765,
0.01451143,
-0.00034297144,
0.029598087,
0.018119678,
-0.008255827,
-0.0028679683,
-0.0042455737,
0.007902846,
-0.007399522,
-0.016524727,
-0.0030395563,
0.000365237,
0.01789743,
-0.020146048,
-0.0024087667,
-0.017191468,
0.014524503,
0.006200041,
0.010014194,
-0.010929329,
0.0011087843,
-0.0016309017,
-0.03386,
0.0362655,
0.020067608,
-0.023754295,
-0.023466682,
0.010399858,
-0.029937994,
0.00960892,
0.0197277,
0.007412595,
0.0035265388,
0.0022649597,
0.02972882,
-0.011766024,
-0.004373039,
0.061026443,
-0.04003063,
0.008419244,
-0.0028941152,
-0.0035101972,
-0.016746974,
-0.003837031,
-0.0047162147,
0.005422176,
-0.014354549,
-0.010811669,
-0.0077721127,
-0.011197333,
-0.010988159,
0.016825415,
-0.012498132,
-0.003480782,
0.00060260016,
0.012321642,
0.0044743577,
0.0038893246,
0.022107052,
-0.024617137,
-0.015505005,
0.02151875,
-0.03393844,
-0.009432429,
0.015361198,
0.0050397804,
-0.02151875,
0.0024202059,
0.0010319784,
-0.020263707,
-0.009504333,
-0.0005507153,
-0.005095342,
0.0035298073,
0.018368071,
0.02147953,
-0.017988943,
-0.004575676,
-0.030068727,
0.040396683,
-0.0030869471,
0.005680375,
-0.03171597,
0.020721275,
0.015452712,
0.020708201,
-0.007726356,
0.0020917377,
-0.0054744696,
-0.0259114,
0.015518079,
-0.009556626,
0.009818094,
0.014171522,
-0.010798596,
-0.014851337,
0.011994808,
0.0043403558,
-0.0121190045,
-0.027192589,
-0.014432989,
0.0063601895,
0.0025819887,
-0.017479083,
-0.020485954,
0.011145039,
0.0106482515,
-0.0029856286,
0.0017910503,
-0.01466831,
-0.0010777351,
0.002364644,
-0.0140669355,
-0.011308457,
-0.009255939,
-0.0027257956,
-0.008602271,
-0.015701106,
0.0069550276,
-0.036082473,
0.024447184,
-0.009654677,
0.00061567355,
0.004242305,
0.0024545235,
0.0031980707,
-0.017047662,
-0.012726916,
-0.0106482515,
-0.023571268,
-0.013883908,
-0.013158337,
0.019204766,
-0.03540266,
-0.021714851,
-0.008281973,
-0.010275661,
-0.00038341715,
-0.03284028,
0.0072164945,
0.006141211,
-0.012092858,
-0.002126055,
0.007961676,
-0.16367847,
0.018106604,
0.034984313,
-0.018472658,
0.017060734,
0.011811781,
0.033206336,
-0.014785971,
-0.0057359366,
-0.02821231,
0.036082473,
0.0024823043,
-0.033781562,
-0.057627372,
-0.0010082829,
0.0052718325,
0.009955363,
0.024656357,
0.058777828,
0.018891005,
0.0033892686,
-0.005046317,
0.01917862,
-0.028578365,
-0.002258423,
0.014419916,
-0.009053302,
-0.0056673014,
0.011563387,
0.008674175,
-0.028918272,
0.007700209,
0.01801509,
-0.019008666,
0.022277005,
-0.0020933717,
0.0005629716,
-0.0021407628,
-0.011994808,
0.011772561,
-0.013275997,
0.017675182,
-0.0077917227,
0.022120126,
-0.020891229,
0.039821453,
0.025362318,
0.01587106,
0.0064222883,
-0.00015024151,
0.017518302,
-0.0055659832,
0.017296055,
0.019832287,
0.000054693628,
0.013753175,
0.0315068,
0.014158449,
0.007131518,
-0.018969445,
0.005275101,
-0.026042134,
-0.005209734,
-0.009818094,
0.009340916,
-0.014446063,
-0.023179067,
0.019270133,
-0.027271029,
0.015217391,
-0.022499252,
0.011988271,
0.02626438,
-0.022982966,
0.03618706,
0.0074648885,
0.019936875,
0.0079551395,
0.0081969965,
0.01587106,
-0.010184147,
0.033624683,
-0.032892574,
0.01645936,
-0.018041236,
0.013079897,
0.02622516,
0.016590094,
-0.0025460368,
0.0024267423,
0.013792395,
-0.02750635,
0.03085313,
-0.04139026,
0.021727925,
0.016760048,
0.020446735,
0.012432765,
0.002921896,
0.015857985,
0.0069811745,
-0.012203981,
-0.032971013,
0.008478074,
0.047037948,
0.0044547473,
-0.0065987785,
-0.017439863,
0.019662334,
-0.021636412,
-0.008726467,
0.014432989,
0.0014846434,
0.020459808,
-0.02782011,
0.00016321272,
0.015766472,
-0.016760048,
-0.0013645319,
-0.03140221,
0.05809801,
0.0072034216,
-0.043194383,
0.009380136,
-0.020590542,
-0.026212087,
-0.11996115,
-0.015648812,
-0.019701554,
0.017570596,
-0.014132302,
0.005170514,
-0.0040331315,
0.04510309,
0.003967765,
0.03715449,
-0.007804796,
-0.001220725,
0.0022077637,
0.0037062976,
0.02941506,
0.020995816,
0.022133198,
0.0013825078,
0.004105035,
0.03979531,
0.008543441,
-0.0024496207,
0.010216831,
0.005353541,
0.008569588,
0.0025917937,
-0.020146048,
0.023048334,
0.0018809297,
0.013557075,
0.035141192,
0.0023891565,
0.0074256686,
0.009014082,
-0.028003138,
0.01139997,
-0.002250252,
-0.008857202,
0.007236105,
-0.032787986,
0.0065922416,
0.0096677495,
0.022146272,
-0.011275773,
0.002557476,
0.008549977,
-0.011504557,
-0.012190908,
-0.023662781,
-0.022969894,
-0.016041012,
0.005105147,
-0.0063013597,
0.012622329,
0.027061855,
0.0046737264,
-0.00425211,
0.013557075,
-0.013021067,
-0.01323024,
0.0010319784,
0.002268228,
-0.016237114,
0.0070007844,
0.012262812,
-0.008046653,
-0.030042581,
-0.012099395,
-0.0071642012,
-0.015152024,
-0.0027127222,
-0.013740102,
-0.006441898,
-0.0040984983,
-0.03537651,
0.013360974,
-0.008183924,
0.0021178843,
0.0030542638,
0.0012215421,
-0.00018394626,
-0.0031849972,
0.0069484906,
0.000032453594,
-0.0157534,
0.010256051,
0.009223255,
0.025859106,
0.007602159,
-0.008334267,
-0.0126092555,
0.013302144,
-0.013674734,
-0.01878642,
-0.005765352,
0.0009641603,
0.0023090823,
-0.015204318,
0.04392649,
0.02283916,
-0.027924698,
-0.01610638,
-0.058464065,
0.023257507,
0.006392873,
-0.0014642163,
-0.014210742,
-0.008556514,
0.017086882,
0.014995144,
0.009955363,
0.000687577,
-0.010432541,
0.0025607443,
-0.029754968,
0.015583445,
-0.013504781,
-0.03843568,
0.028735245,
0.010465224,
0.002557476,
0.006268676,
0.008458464,
-0.005902622,
0.013753175,
-0.0011602608,
-0.026656581,
-0.01319102,
0.017322201,
-0.00016893233,
-0.0042553786,
0.0029774578,
0.005046317,
-0.038670998,
0.0011406507,
0.0025117192,
0.009367063,
-0.034565963,
-0.004846948,
0.032317348,
0.0140800085,
0.014040789,
-0.02147953,
-0.023675855,
0.008105483,
-0.002498646,
-0.0017354885,
0.007595622,
-0.003047727,
-0.011687584,
-0.002433279,
0.0006430459,
0.0426453,
-0.00094618445,
-0.0049744137,
-0.007308008,
-0.01579262,
0.015583445,
0.002327058,
0.0019822482,
-0.014655236,
-0.039324667,
0.024277229,
-0.0076871356,
0.0111385025,
0.004206354,
-0.011746414,
0.0082035335,
-0.004000448,
0.0009412819,
0.009595846,
0.0034938555,
-0.027323322,
-0.021492604,
0.012334716,
-0.017387569,
0.013504781,
-0.0042030853,
-0.027218735,
0.015374271,
-0.020930449,
0.003565759,
0.0064451667,
-0.02555842,
0.0038043477,
-0.012217055,
0.01669468,
0.017518302,
-0.011073136,
0.014759824,
0.017178396,
-0.008314657,
-0.0071576647,
0.005275101,
0.0075890855,
-0.012249738,
0.003912203,
0.03545495,
-0.0052031972,
-0.02000224,
0.014354549,
0.0066543403,
0.008674175,
0.007497572,
0.0052620275,
-0.02459099,
-0.025231585,
-0.03310175,
-0.031036157,
-0.030905424,
-0.010027267,
0.03318019,
0.016080232,
0.0046835314,
0.023963468,
0.000044403463,
0.009857314,
-0.002144031,
0.009537016,
0.013635514,
-0.013648588,
0.042357687,
0.00097396533,
0.0063013597,
0.008183924,
0.017962797,
-0.006343848,
0.013949275,
0.016524727,
-0.013923128,
0.031140743,
-0.016786193,
-0.0033958054,
-0.026852682,
-0.025283879,
-0.0012648476,
0.0019871506,
-0.0073668384,
0.017845137,
0.029990287,
0.02120499,
0.07676677,
-0.0057816934,
-0.029310472,
0.015570371,
-0.008046653,
0.011792171,
-0.0034056103,
0.0007423217,
-0.009347453,
-0.034461375,
0.010550202,
-0.011589534,
0.030591663,
-0.027532496,
-0.046515014,
0.0041017667,
-0.0069158073,
0.046018228,
0.0114588,
-0.026761169,
0.051299866,
-0.011922904,
0.005105147,
0.02268228,
-0.031323772,
-0.0056836433,
0.015361198,
-0.004108303,
-0.008027043,
-0.03291872,
-0.0045299195,
0.019191692,
-0.019309353,
-0.0058960854,
-0.010086097,
-0.012132078,
-0.0062882863,
-0.0017142444,
-0.011393433,
-0.009229792,
-0.024656357,
0.040762737,
-0.025087778,
-0.011968661,
-0.007379912,
-0.0038206894,
-0.032395788,
-0.0041475235,
-0.02260384
] |
The promyelocytic leukaemia zinc finger (Plzf) protein (encoded by the gene Zfp145) belongs to the POZ/zinc-finger family of transcription factors. Here we generate Zfp145−/− mice and show that Plzf is essential for patterning of the limb and axial skeleton. Plzf inactivation results in patterning defects affecting all skeletal structures of the limb, including homeotic transformations of anterior skeletal elements into posterior structures. We demonstrate that Plzf acts as a growth-inhibitory and pro-apoptotic factor in the limb bud. The expression of members of the abdominal b (Ab | [
-0.037397917,
-0.003502677,
-0.0074376995,
-0.037397917,
-0.021860486,
0.03515512,
-0.03299339,
-0.00012803602,
-0.01857736,
-0.00928868,
0.016321056,
-0.005552942,
0.015929243,
0.020685047,
-0.02291433,
-0.006461544,
0.010139861,
0.00232217,
0.007660628,
0.023657424,
-0.013146016,
0.01338921,
-0.00030905972,
-0.01772618,
0.0041174185,
-0.001411035,
0.0073363683,
-0.03380404,
-0.0018729357,
-0.013862088,
0.014956464,
0.013571606,
-0.005360413,
0.010889711,
-0.017847776,
-0.009504853,
0.015442853,
-0.029507603,
0.016645314,
-0.006978332,
0.03277722,
0.023779022,
-0.023643913,
-0.0045159874,
-0.019604182,
-0.010916732,
-0.0031345075,
0.002717361,
-0.022306344,
0.00025079437,
0.006356835,
0.00041207962,
0.0060562193,
-0.01572658,
-0.008721226,
-0.028886106,
0.029561646,
0.010376301,
-0.0035871195,
-0.021995595,
-0.011099128,
0.010247948,
-0.020658026,
0.008322657,
0.012490742,
0.005698183,
-0.015523918,
0.0036681842,
0.002401546,
0.0047828257,
0.058204558,
0.017185748,
-0.0048233583,
-0.0076741385,
0.04547738,
0.0060866186,
-0.024724778,
0.016131904,
-0.024927441,
-0.0067283823,
0.020833666,
-0.0074512106,
-0.017807245,
0.005009132,
0.018347677,
-0.008119996,
0.018266613,
0.020820154,
-0.0018290256,
0.0027697156,
0.024062749,
-0.0028744242,
0.016712869,
-0.0051813945,
-0.015740091,
-0.014064751,
0.016510207,
0.008052441,
0.010383056,
-0.025292233,
-0.024157325,
0.009930444,
-0.008640162,
-0.008761759,
-0.019941952,
-0.0040870192,
0.001835781,
0.00836319,
0.021333566,
-0.0070391307,
-0.03464171,
0.053664926,
0.016415631,
-0.03699259,
0.021211969,
-0.024508605,
-0.000040796305,
0.01053843,
-0.01906375,
0.0075660525,
0.028723978,
0.052584063,
-0.0044990988,
-0.027332364,
0.027778221,
0.025670534,
-0.0018915131,
-0.0015925864,
-0.012342122,
0.004066753,
0.023792531,
0.015740091,
0.015334766,
-0.0015191215,
-0.011767914,
0.0033337919,
-0.018807044,
-0.016158925,
-0.04331565,
-0.03393915,
0.015577961,
0.025792131,
-0.022036128,
0.0035567202,
0.01472678,
0.011234237,
0.013510807,
-0.0037222274,
0.018374698,
-0.011335568,
0.0074174334,
-0.018820556,
0.033209566,
-0.010882956,
-0.0002911157,
0.0052624596,
0.0011433521,
0.03258807,
-0.015591472,
-0.03093975,
-0.024170835,
-0.0039823106,
0.009153572,
0.01923939,
0.034992993,
0.034560647,
0.0020722202,
-0.004475455,
0.013260858,
-0.0013781023,
-0.006404123,
0.019779822,
-0.037424937,
0.005927867,
-0.009781824,
-0.009552141,
-0.004610563,
0.001972578,
-0.026494693,
-0.009491342,
-0.0043471023,
0.031804442,
0.004590297,
0.019266412,
-0.02141463,
-0.0075322753,
0.0126393605,
-0.019712267,
-0.017010108,
-0.016969575,
0.01988791,
-0.0062588817,
0.017645115,
-0.020847175,
-0.6346837,
-0.020820154,
0.015537429,
-0.0039485334,
0.005134107,
0.02977782,
-0.014767312,
-0.024197856,
-0.011524719,
0.0227522,
-0.009119795,
0.013760758,
0.016091373,
-0.032371894,
-0.0117746685,
-0.010025019,
-0.011754403,
-0.03666833,
0.024224877,
0.014983485,
-0.020617492,
0.011362589,
0.012186749,
0.02758907,
0.0028963794,
0.019644715,
0.031885505,
-0.02826461,
0.0025687423,
0.006164306,
-0.029615691,
0.011747647,
-0.02861589,
0.027048636,
0.049098276,
0.0071539725,
-0.0046375846,
0.040235184,
-0.0042998143,
0.031804442,
-0.009234637,
0.011024819,
0.022968372,
0.0025349653,
-0.017118193,
0.0021228855,
0.0025873196,
0.03210168,
0.017482985,
0.009302191,
0.013889111,
-0.010437099,
-0.013693203,
-0.016131904,
0.012997397,
0.013220325,
0.022968372,
-0.025359785,
0.018861087,
-0.017347878,
-0.005154373,
0.01522668,
0.004374124,
-0.02192804,
0.0098764,
0.01362565,
0.0016424075,
0.010545186,
0.0014355233,
0.0041680844,
0.009234637,
0.020360786,
0.00009621173,
0.016996596,
0.0071134404,
0.033425737,
-0.009356234,
0.004624074,
-0.010491142,
0.00090606854,
0.0039958213,
-0.0048537576,
-0.03280424,
-0.0011813513,
0.020712068,
0.004225505,
-0.021819955,
0.019766312,
-0.012896066,
0.0020097326,
0.008741492,
-0.018996196,
-0.021671336,
-0.03945156,
-0.040910725,
0.0027849153,
-0.0067114937,
0.012504253,
0.0007101618,
-0.0158752,
-0.016699359,
-0.018536828,
0.022536026,
-0.0073025916,
-0.0052084164,
0.024373498,
-0.016429141,
0.008282125,
0.031047836,
-0.027480982,
-0.018982684,
0.007741693,
0.00652572,
-0.0086063845,
-0.0078700455,
-0.031669334,
0.0051813945,
0.019144814,
-0.012308346,
-0.021049839,
0.009795335,
0.0000928868,
0.008984687,
0.0016846288,
0.014915932,
0.004884157,
-0.0016643626,
0.0053063696,
-0.003048376,
-0.01838821,
0.023265611,
-0.017604582,
0.019698758,
-0.03631705,
0.013537829,
0.0007528053,
0.024238389,
0.020644514,
0.02926441,
-0.016239991,
-0.015118593,
-0.011146416,
0.001506455,
-0.02742694,
-0.0046510957,
-0.026021816,
0.0008081152,
0.002947045,
0.020766111,
0.0039789327,
0.0007532275,
-0.011058596,
-0.011119395,
0.0127271805,
0.02006355,
-0.0046173185,
-0.017050639,
-0.020360786,
0.007329613,
-0.01872598,
0.0056036073,
0.012950109,
0.001802004,
-0.003387835,
0.00027401606,
-0.015348277,
0.018266613,
0.0009508231,
-0.00877527,
-0.028183544,
0.006596652,
-0.0023998572,
-0.019185347,
-0.010065552,
-0.022954863,
0.0069985986,
0.009923688,
-0.0066912277,
0.0018560472,
-0.011876,
-0.008268614,
-0.017591072,
-0.014361989,
0.007626851,
0.026413629,
0.02290082,
0.01655074,
0.03177742,
0.007424189,
0.031912528,
-0.015091572,
0.00015590206,
-0.024832865,
0.008180794,
-0.01556445,
-0.022076659,
0.014280924,
0.01505104,
-0.0115990285,
0.026251499,
-0.0060899965,
-0.020495895,
0.00836319,
-0.0028136256,
0.017253302,
-0.032669134,
0.0108762,
-0.022468474,
0.0092143705,
0.012889311,
-0.005130729,
0.0023660802,
-0.024819354,
-0.0020536426,
-0.0026379852,
0.002560298,
-0.0027241167,
-0.0012902821,
0.0021296411,
0.00044247895,
-0.001835781,
-0.007174239,
0.01873949,
0.0035634756,
0.0047794483,
0.010511409,
0.011896266,
0.00920086,
0.015010507,
-0.014132305,
0.0040295986,
0.027697155,
-0.008667183,
0.0018290256,
-0.008092973,
0.01621297,
0.014118794,
-0.031182945,
0.03310148,
-0.0027055393,
-0.009822357,
0.011038329,
0.010281725,
0.021374097,
0.005934622,
-0.016131904,
0.012821756,
0.0005214327,
-0.0060190647,
0.02192804,
-0.010639761,
0.03496597,
-0.012004352,
-0.0034368117,
0.009180594,
-0.0028254476,
-0.009727782,
0.0056711617,
0.025778621,
0.02476531,
0.02091473,
-0.018185547,
-0.012950109,
-0.007876801,
0.021347076,
-0.00489429,
-0.011261258,
-0.041045833,
-0.004485588,
-0.0022343497,
-0.029183345,
0.015821155,
0.000470345,
-0.027656624,
-0.0029892663,
0.0113828555,
0.0072282823,
0.024157325,
0.011261258,
0.0015030773,
0.002560298,
-0.031345073,
0.015807645,
0.03177742,
-0.02458967,
-0.021982085,
-0.030426338,
0.013395966,
0.0055698305,
0.0009609562,
0.0009145128,
0.0039248895,
0.00034304784,
-0.0006476743,
-0.00018419031,
0.002300215,
0.006454788,
-0.021320054,
0.006833091,
-0.018766511,
-0.022009106,
-0.006076486,
-0.034533624,
0.003918134,
0.038073458,
-0.004917934,
0.0025788755,
-0.017131705,
-0.013321657,
-0.00996422,
0.013666182,
-0.020171637,
0.01857736,
-0.00870096,
-0.00656963,
-0.014294434,
0.0071877497,
0.0056914277,
0.02206315,
0.0063298135,
-0.043747995,
-0.041505203,
-0.0057049384,
0.006346702,
0.011761158,
0.055826657,
0.008356434,
0.01313926,
-0.008457766,
0.010133105,
-0.0128758,
-0.0044822106,
0.028994193,
0.0027443827,
-0.0007316947,
-0.0028930018,
-0.0024302565,
0.010018264,
-0.013889111,
0.0117273815,
0.011659827,
-0.028237589,
0.010612739,
-0.0074849874,
-0.0077484483,
0.0017716046,
0.026413629,
0.033533823,
0.013652671,
0.021036327,
-0.0038269362,
0.021347076,
-0.0042423937,
-0.011281525,
-0.006647317,
-0.007160728,
-0.002323859,
0.0067148716,
-0.007444455,
-0.016591271,
-0.0026126525,
-0.0047794483,
0.008741492,
0.0037424937,
0.024832865,
0.007728182,
0.00008022042,
-0.029318452,
-0.00978858,
-0.000014935776,
0.007741693,
-0.0024623447,
0.005813025,
-0.024197856,
0.03177742,
-0.021049839,
-0.0006210749,
-0.006924289,
0.023657424,
-0.016185947,
-0.011882755,
-0.016280523,
-0.0062487484,
-0.035182144,
0.005336769,
-0.015172637,
-0.003536454,
0.00071733946,
0.0020012883,
-0.0023880352,
0.0040295986,
0.0037019614,
-0.024359986,
-0.02273869,
0.02006355,
-0.015956264,
-0.03666833,
-0.013321657,
0.009471077,
0.008626651,
0.013227081,
-0.021806443,
-0.0029841997,
0.005711694,
0.0110788625,
-0.008741492,
-0.008795536,
-0.046531223,
-0.000026929256,
0.006150795,
0.019185347,
-0.020468874,
-0.003580364,
0.010862689,
0.011153172,
0.010801891,
0.022495495,
0.002752827,
-0.007005354,
0.008430744,
0.008018664,
0.031101879,
-0.0031260632,
0.011416633,
-0.008322657,
-0.032020614,
-0.017969374,
-0.017996395,
-0.0133756995,
-0.00030357097,
0.013956664,
0.012450209,
-0.0222523,
-0.023630403,
-0.006039331,
-0.009761559,
0.012071907,
0.026521716,
0.028534826,
0.03296637,
0.006387234,
0.024143813,
0.013902621,
-0.013429743,
0.008248348,
-0.014578162,
0.00786329,
0.012456965,
-0.016766911,
0.012065151,
0.012098928,
-0.02123899,
-0.015105083,
0.004803092,
-0.01271367,
0.04682846,
-0.0018188924,
0.0048571355,
-0.011153172,
0.0074849874,
0.0014895665,
-0.0052759703,
0.009727782,
0.00015115216,
-0.012760958,
0.0019742667,
0.0085185645,
-0.026237989,
0.017510006,
-0.033398718,
-0.00059743103,
0.020306744,
-0.0051172185,
-0.012281324,
-0.013902621,
0.021711867,
0.010187149,
-0.014213369,
-0.015983285,
-0.03177742,
0.01755054,
-0.03496597,
0.018888108,
0.02695406,
0.028723978,
0.014794335,
0.0035263207,
0.031182945,
-0.00870096,
0.0039721774,
0.00038864682,
0.019631203,
-0.024981484,
0.037776217,
0.013632405,
0.0020570206,
0.03618194,
-0.028318653,
0.025670534,
0.020360786,
-0.028886106,
0.003772893,
0.02191453,
-0.023860086,
-0.036344074,
0.0027578936,
-0.009910177,
0.012261058,
-0.029723777,
-0.016523717,
0.009092773,
0.011585518,
0.00067765143,
-0.0014338344,
-0.0002710606,
-0.0112950355,
0.04785528,
0.0028153146,
0.019874398,
-0.010680294,
-0.010383056,
0.0099507095,
-0.002967311,
0.0047760704,
-0.013470275,
0.014226881,
-0.0015756979,
-0.02745396,
0.0059785326,
0.0067351377,
-0.02290082,
0.00070467306,
-0.017280323,
-0.007741693,
-0.025481382,
-0.016496696,
0.00564414,
-0.0485038,
0.009356234,
-0.0015140548,
-0.019941952,
0.0008883356,
0.0054212115,
-0.021063348,
0.014361989,
-0.017293833,
0.03377702,
-0.0062014605,
0.0109910425,
0.02560298,
0.0023069703,
-0.027967371,
-0.008511809,
-0.005029398,
0.028237589,
0.016010307,
0.015253702,
-0.010315502,
-0.010869444,
0.022157725,
0.011544985,
-0.024562648,
-0.031182945,
0.0060595972,
-0.017104682,
0.0044011455,
-0.0038100479,
0.005596852,
-0.02291433,
-0.0023964795,
-0.015469875,
-0.000041456013,
-0.019198857,
-0.014118794,
-0.020752601,
0.013085217,
-0.0023069703,
-0.004532876,
-0.0035567202,
-0.010646516,
0.005225305,
-0.008133506,
-0.0015174326,
0.019469073,
-0.0035533423,
0.027156724,
0.0017732935,
0.013929643,
0.012781224,
0.013767513,
0.0026531848,
-0.0050733085,
0.00035592535,
0.037533022,
-0.025049038,
0.008849579,
-0.0007139617,
-0.010342523,
-0.0058062696,
-0.006002176,
-0.0054718773,
-0.019779822,
-0.030642511,
-0.000031428463,
0.021495694,
0.011848979,
-0.0030787752,
-0.0053333915,
-0.028886106,
-0.0023441252,
-0.02242794,
-0.023008905,
-0.0014887222,
-0.05166533,
0.0070188646,
0.009471077,
0.040100075,
0.007667383,
0.015064551,
-0.015442853,
-0.008187549,
0.029210366,
-0.0202527,
0.020036528,
-0.010065552,
-0.008667183,
-0.04231585,
0.0066236733,
-0.0024336341,
-0.016929042,
0.0067351377,
-0.029561646,
-0.032047637,
0.007160728,
-0.021765912,
0.025724579,
0.015753603,
-0.026359586,
0.008977932,
0.004630829,
0.026994593,
-0.0097345365,
0.0057995142,
0.019158326,
-0.016942553,
0.004887535,
0.009491342,
0.0071066846,
-0.008011909,
0.013146016,
-0.0019084016,
0.02958867,
0.0022056394,
-0.037587065,
0.011443654,
-0.0031311298,
-0.003252727,
-0.0036377849,
-0.027805243,
-0.0127271805,
-0.0023086593,
0.0056373845,
0.0060359533,
-0.014551139,
-0.012896066,
-0.0013882355,
-0.0058636907,
0.02541383,
-0.010612739,
-0.012619094,
0.010477631,
-0.047882304,
-0.042883303,
0.005927867,
-0.043450758,
0.016496696,
-0.00936299,
-0.02159027,
-0.00752552,
0.023441251,
-0.03726281,
-0.008883356,
-0.018982684,
0.0059244893,
0.012815001,
0.008032175,
0.004917934,
0.010173638,
0.009633206,
0.021982085,
0.0141998585,
-0.043747995,
0.004813225,
-0.010335768,
0.008322657,
-0.010464121,
-0.029831864,
-0.019901419,
0.030642511,
0.001127308,
-0.008977932,
0.035074055,
-0.039370492,
0.02558947,
-0.013017663,
0.029102279,
0.026170434,
0.0030787752,
0.032831263,
-0.016469674,
-0.02608937,
-0.017631603,
0.01606435,
0.0016643626,
0.0022917707,
0.022279322,
-0.002290082,
-0.006194705,
-0.01372698,
-0.013781024,
0.026292032,
0.00036901393,
0.02826461,
-0.0030534426,
0.0066338065,
0.015794134,
0.012835267,
0.019347476,
-0.014159326,
-0.007572808,
-0.025711067,
-0.0041984837,
0.004681495,
0.0212525,
-0.0009423788,
-0.010720826,
-0.0031801064,
-0.02090122,
0.0063534575,
-0.017212769,
-0.016294034,
-0.014672737,
0.02727832,
-0.017347878,
0.004792959,
-0.0000027163453,
-0.0069715767,
-0.015672537,
-0.031696353,
0.00045598976,
-0.011193704,
0.0036208965,
-0.02677842,
-0.0057826256,
-0.02107686,
-0.0053502796,
-0.015091572,
-0.008444255,
0.023292633,
0.03177742,
0.18850279,
-0.018442253,
0.00016202414,
0.0016972952,
-0.0021330188,
0.012693404,
0.020968774,
-0.011842223,
-0.006576386,
0.00093731226,
0.0037931593,
-0.009856134,
-0.0014456564,
0.004225505,
0.0017868043,
-0.028994193,
-0.016253501,
-0.0037120944,
-0.022198256,
-0.010660027,
0.023995195,
-0.032398917,
0.025778621,
0.008714471,
0.026548738,
0.03045336,
-0.036614288,
0.020117592,
-0.00031919283,
0.01955014,
-0.012632605,
-0.0016500074,
-0.000990511,
-0.0068297135,
-0.0024099904,
0.003945156,
-0.008930644,
-0.011281525,
0.019685246,
-0.0020975529,
-0.0027629603,
-0.005292859,
-0.0064277668,
-0.0028963794,
-0.008187549,
-0.0010301991,
0.00066456286,
-0.0076808943,
-0.0076876497,
0.027129702,
-0.026346074,
0.0024116791,
0.0148078455,
0.021819955,
-0.002063776,
-0.008721226,
0.013490542,
-0.00069454,
0.0013375699,
0.013240592,
0.010660027,
0.014172837,
-0.032696154,
0.011646316,
-0.010430343,
0.02073909,
0.0016103194,
0.00089340215,
0.008106485,
-0.033831064,
-0.013112239,
-0.014416032,
0.003772893,
0.0044822106,
-0.0046139406,
-0.041559245,
0.023400718,
0.017212769,
0.030885706,
0.020306744,
0.011186949,
0.004022843,
-0.031993594,
-0.008065952,
0.0019438674,
-0.019050239,
0.018617893,
0.007890312,
-0.019455563,
-0.028832063,
0.011889511,
-0.023387209,
-0.003522943,
0.0131595265,
0.005532676,
-0.004022843,
-0.021360587,
0.026900018,
-0.006650695,
-0.016172437,
-0.025386808,
0.04753102,
0.0072012604,
0.012929843,
-0.010335768,
0.003897868,
0.0010352656,
0.015577961,
0.004147818,
-0.017537028,
0.015037529,
0.0027139834,
0.010376301,
-0.0019404897,
0.015645515,
-0.008457766,
0.0060933745,
-0.007295836,
0.0311289,
-0.01488891,
-0.005316503,
-0.033182543,
0.023779022,
0.033695955,
-0.008971176,
-0.011085617,
-0.038073458,
0.004907801,
-0.015780624,
-0.018847577,
-0.0019438674,
0.008396967,
0.008673939,
0.0035263207,
-0.014375499,
-0.011409877,
-0.00811324,
0.018847577,
-0.02745396,
0.009599429,
-0.019968973,
-0.01722628,
0.01196382,
-0.0074647213,
-0.021860486,
-0.011139661,
0.033398718,
0.025319254,
-0.016172437,
-0.017212769,
-0.020766111,
-0.01011284,
-0.0082618585,
-0.027210766,
0.010822157,
-0.037533022,
-0.022454962,
-0.033344675,
-0.008315902,
0.00090015755,
-0.022144213,
0.0154158315,
-0.00702562,
-0.020941751,
0.0052996143,
-0.0077011604,
-0.1716413,
0.009829112,
0.009923688,
-0.0317504,
0.030534426,
0.04231585,
-0.0067722923,
-0.013456765,
-0.0045193653,
0.025657024,
0.02891313,
-0.002967311,
-0.032723177,
-0.015469875,
-0.009977732,
-0.0050395313,
-0.031074857,
0.036857482,
0.021184945,
0.027440451,
0.00861314,
-0.004036354,
0.032750197,
0.020955263,
0.018590871,
0.0051813945,
0.022806244,
-0.018482786,
-0.00010212271,
-0.009498098,
-0.0042559044,
0.00027063835,
0.03945156,
0.002209017,
0.004847002,
0.0011990842,
0.016685847,
-0.00040067988,
-0.010477631,
0.031858485,
0.030318253,
0.01688851,
-0.0079983985,
-0.015159126,
0.006620296,
0.050962765,
-0.010369545,
-0.027224278,
0.01907726,
0.00080135977,
0.023508806,
-0.0022377274,
0.009356234,
0.007816002,
0.031236988,
-0.004553142,
-0.006448033,
-0.000009757073,
-0.0017547162,
-0.0034047235,
-0.00008022042,
-0.011666582,
0.031264007,
-0.0073971674,
0.01471327,
-0.021563249,
0.0053536575,
0.029048236,
-0.0401271,
-0.011653071,
-0.0069850874,
-0.0061811944,
0.024805842,
-0.016091373,
0.025805643,
0.008917133,
-0.015915731,
0.009768314,
-0.0034722777,
-0.004576786,
-0.007126951,
0.022549538,
-0.015456364,
-0.018131504,
-0.008673939,
0.0026987838,
-0.0016719624,
0.003921512,
-0.005742093,
-0.02107686,
0.008403722,
-0.014280924,
-0.011153172,
-0.002855847,
0.021941552,
0.033831064,
-0.013808046,
-0.020590471,
-0.023049438,
0.023279121,
0.03726281,
-0.01338921,
-0.02996697,
-0.004772693,
0.04566653,
-0.0067047384,
0.0046510957,
0.0154158315,
0.057177737,
-0.011707115,
0.01809097,
-0.0034013458,
0.0036681842,
0.0055259205,
0.000996422,
0.019320454,
0.01923939,
-0.005958266,
0.021549739,
-0.032858282,
0.062149715,
-0.0012826823,
-0.008153772,
0.04193755,
-0.024630202,
-0.0028305142,
-0.11673338,
-0.00007847879,
0.0059312447,
0.01906375,
-0.005701561,
-0.0009846002,
-0.00045345648,
0.02257656,
0.0019252901,
0.027778221,
-0.012092173,
-0.009477831,
0.006380479,
-0.0046848725,
0.0072012604,
0.008444255,
0.01906375,
-0.013031174,
-0.042559043,
0.029237388,
-0.009173838,
0.008856335,
-0.0057319603,
-0.005961644,
0.015632004,
0.0052557043,
-0.033209566,
0.0017040506,
0.010660027,
0.0006029198,
0.013564851,
-0.037695155,
0.027751198,
-0.00057083165,
-0.03264211,
0.0031665955,
0.011362589,
-0.0119030215,
0.03229083,
-0.014470075,
0.008322657,
-0.005816403,
-0.011977331,
-0.025049038,
-0.0029706887,
-0.0048098476,
-0.014524118,
0.0152401915,
0.027670134,
-0.02342774,
-0.028561847,
-0.03296637,
-0.03429043,
-0.008984687,
0.023603382,
-0.026400119,
0.0021651068,
0.021698358,
-0.030696554,
-0.011409877,
0.01296362,
0.010220926,
-0.005667784,
-0.00877527,
0.015348277,
0.006323058,
-0.010781624,
-0.026156923,
0.016645314,
-0.024224877,
-0.007822758,
0.029210366,
-0.0022343497,
-0.0016086305,
-0.023792531,
0.0026548738,
-0.022590071,
-0.009511609,
0.023360187,
-0.05139511,
-0.001099442,
-0.011984087,
0.018036928,
-0.009335968,
0.033695955,
0.026319053,
0.032047637,
-0.014537629,
0.014551139,
-0.010416833,
-0.016361589,
0.042396914,
-0.003522943,
-0.016591271,
-0.039019212,
0.016523717,
0.010247948,
-0.020631004,
0.018199058,
0.04196457,
-0.021441652,
-0.024211368,
-0.060042027,
0.019955464,
-0.011085617,
-0.013510807,
-0.00069116225,
-0.010247948,
0.009058996,
0.0070121093,
-0.004320081,
0.02040132,
-0.005883957,
0.010687049,
-0.028723978,
-0.01271367,
-0.016429141,
-0.0046206964,
0.040019013,
-0.0040295986,
0.02022568,
0.017969374,
0.008423989,
0.0010158438,
0.0062115937,
0.015105083,
-0.016334567,
-0.018023418,
-0.029318452,
0.013943153,
-0.003536454,
0.014361989,
-0.0064210114,
-0.04685548,
-0.026629802,
0.002050265,
-0.0066777165,
-0.036884505,
0.006083241,
-0.0071134404,
0.021387609,
0.013490542,
0.009079263,
-0.014956464,
0.0067351377,
0.0061811944,
0.013240592,
-0.0040701306,
-0.021374097,
-0.0064210114,
0.005367168,
-0.00936299,
0.031372096,
0.010822157,
0.015037529,
-0.021995595,
-0.014416032,
0.016469674,
-0.0013401032,
-0.012909576,
-0.00827537,
-0.006414256,
0.02444105,
0.019779822,
0.005674539,
-0.006978332,
-0.017537028,
-0.002889624,
-0.008126751,
0.0011906399,
0.0032358384,
-0.027535027,
-0.030912727,
0.01722628,
0.019806843,
0.0099507095,
0.021779422,
0.006076486,
-0.020131104,
-0.010423588,
-0.026656823,
0.03299339,
0.016942553,
0.0129838865,
0.00282207,
-0.00025353875,
0.047233783,
-0.015429342,
-0.028156523,
0.012565051,
0.003604008,
0.014470075,
-0.018117992,
0.022887308,
-0.00380667,
0.023968173,
0.009856134,
-0.0067283823,
0.0013781023,
0.0049989987,
-0.0075322753,
0.02240092,
-0.017510006,
-0.014537629,
0.010572207,
-0.016577762,
-0.002526521,
0.025346275,
-0.022103682,
-0.041559245,
0.0060460865,
0.005269215,
0.037884306,
0.008248348,
-0.009369745,
-0.0031784174,
0.008755003,
0.030993793,
-0.0010411766,
-0.01773969,
-0.0033827685,
0.031669334,
0.013645915,
0.005674539,
-0.008160528,
-0.017591072,
0.011173438,
0.0015554318,
0.025008505,
-0.011619295,
0.02444105,
-0.010241192,
0.006400745,
0.02676491,
-0.025684046,
-0.012781224,
0.01011284,
0.0039958213,
0.026751399,
0.008052441,
-0.006323058,
0.10722177,
-0.00019865109,
-0.018253101,
0.0020080437,
-0.02742694,
0.009403522,
-0.0042863037,
0.019496096,
-0.0010073996,
-0.044207364,
0.0054786326,
-0.027805243,
0.026521716,
-0.021995595,
-0.02392764,
-0.00064725213,
-0.014834867,
0.008646917,
-0.021049839,
-0.014875399,
0.0042660376,
-0.01622648,
0.008268614,
0.016037328,
-0.038884103,
-0.013605383,
0.025292233,
0.0063264356,
0.012261058,
-0.003911379,
-0.00227826,
-0.02694055,
-0.031534225,
0.0012995708,
0.022454962,
-0.017010108,
-0.014186348,
-0.035587467,
-0.0050361534,
0.021684846,
-0.007289081,
0.006360213,
-0.018604383,
-0.0132000595,
0.017118193,
-0.0007055175,
0.0134635195,
0.0028778021,
-0.032615088
] |
Small regulatory RNAs are key regulators of gene expression. One class of small regulatory RNAs, termed the endogenous small interfering RNAs (endo siRNAs), is thought to negatively regulate cellular transcripts via an RNA interference (RNAi)-like mechanism termed endogenous RNAi (endo RNAi). A complex of proteins composed of ERI-1/3/5, RRF-3, and DICER (the ERI/DICER complex) mediates endo RNAi processes in Caenorhabditis elegans. We conducted a genetic screen to identify additional components of the endo RNAi machinery. Our screen recovered | [
-0.032006264,
0.0072094644,
-0.004920426,
-0.023212597,
-0.002654882,
0.013814784,
-0.021440437,
0.0069006793,
-0.008108969,
-0.0091293035,
0.014271249,
-0.005715884,
0.0051016696,
0.010679943,
-0.0066825156,
0.007800184,
0.018124351,
-0.0018443207,
0.028837858,
0.009800576,
-0.024662545,
0.03702738,
-0.011928509,
-0.024944479,
-0.0045545823,
-0.0003022823,
0.009753587,
-0.033321958,
0.0045780772,
-0.04545856,
0.0016102145,
-0.00700137,
-0.020446954,
-0.005262775,
0.009243419,
-0.013237489,
0.011431768,
-0.015278158,
0.009820714,
0.00993483,
0.049110282,
0.016029982,
-0.011297513,
0.014351802,
-0.008907784,
0.00034570522,
0.011418342,
-0.00020232567,
0.00934411,
0.034933012,
0.0044975244,
0.004128325,
-0.01636562,
-0.000074102165,
-0.036597766,
0.018446563,
-0.004856655,
0.019480322,
-0.014069867,
0.002868011,
-0.021923753,
-0.0014147063,
-0.024957905,
0.011331077,
0.011055855,
0.031764604,
0.037725504,
-0.015305009,
-0.0029938745,
-0.002535731,
0.016607277,
0.01747993,
-0.012156742,
0.020057617,
0.0014692473,
-0.029911892,
-0.012700472,
0.027951779,
0.014955946,
0.006759712,
0.006007887,
-0.00091796485,
-0.017359102,
0.012928705,
0.013109948,
-0.018929878,
0.0033580395,
0.025038457,
0.004715688,
-0.013304617,
0.03227477,
0.039927278,
0.021950604,
0.019346068,
-0.021319607,
-0.0023544875,
0.005850138,
0.02366906,
-0.015318434,
-0.034852456,
-0.01225072,
0.017412804,
-0.010485273,
-0.003230498,
-0.01801695,
-0.008162671,
-0.0010111039,
-0.019909937,
0.027790673,
-0.006659021,
-0.029267471,
0.0033681088,
0.0077397698,
-0.022353368,
0.016741531,
0.0029838053,
0.050238017,
-0.006333454,
-0.017681312,
-0.015962856,
0.016714681,
0.0070282207,
0.023118617,
-0.044062313,
0.026931444,
0.016352193,
0.018339159,
0.013687242,
-0.012431963,
0.0019920005,
0.0022705786,
0.0029200346,
-0.005155371,
0.004853299,
-0.030636868,
-0.008162671,
-0.017359102,
-0.0034637651,
0.0068939663,
-0.03487931,
0.020003915,
0.03737644,
-0.050748184,
0.0036953539,
0.002441753,
0.0021027604,
0.012599781,
0.020030765,
0.018151203,
0.007921013,
-0.009807289,
-0.008807093,
0.005786367,
-0.009115878,
0.00035094956,
0.042880874,
-0.0035577433,
0.026206471,
-0.004319637,
-0.011042429,
-0.0021111513,
-0.016459597,
0.012955556,
0.00280424,
0.013217351,
0.024608843,
-0.012660195,
-0.0037289176,
0.014432354,
-0.003953794,
-0.009330685,
0.0101832,
-0.03254328,
0.023749614,
-0.0012569574,
0.014620311,
-0.01459346,
0.017493356,
-0.014888819,
-0.013365031,
0.011029004,
-0.020084467,
0.023749614,
-0.008813805,
-0.0069879447,
-0.021037674,
0.0077263443,
0.008592285,
0.006739574,
-0.015627218,
-0.015412412,
-0.00032997227,
0.013009257,
-0.0026783764,
-0.6225111,
-0.04607613,
0.029455429,
-0.026474979,
0.015909154,
0.027629567,
-0.0034285232,
-0.0041618883,
0.016660979,
0.035899643,
-0.022125134,
0.010364444,
0.02420608,
-0.020742314,
-0.02916007,
-0.040786505,
-0.0011965429,
-0.0009574021,
0.03375157,
-0.005776298,
-0.02225939,
0.010277179,
0.01476799,
0.02107795,
0.00813582,
-0.014861968,
0.015909154,
-0.019211814,
-0.008263362,
0.025763432,
-0.0074981116,
0.022742705,
-0.018124351,
0.00813582,
0.051902775,
0.005806505,
-0.011304226,
0.02004419,
0.0031952562,
0.021708947,
-0.027710121,
0.008927922,
0.034449693,
-0.0032321762,
0.003953794,
0.0099415425,
-0.0011201856,
0.0016278353,
0.018325733,
-0.012754174,
0.007800184,
0.022299666,
-0.022044582,
0.011391491,
0.011720414,
0.006205912,
0.033644166,
-0.01242525,
0.018795624,
-0.004225659,
0.0012351411,
0.026864316,
-0.029482279,
-0.022621876,
0.013499286,
-0.0026196402,
-0.008437892,
0.0032690961,
0.006007887,
0.0024920984,
0.032086816,
0.027347634,
-0.012525941,
-0.002775711,
0.0040041395,
0.034798756,
0.006813414,
0.021359885,
-0.010015382,
0.025696304,
0.0035241796,
-0.011317651,
-0.031415544,
0.005152015,
0.015855452,
-0.002857942,
-0.015023074,
0.014647162,
-0.0007027382,
-0.001122703,
-0.007612228,
-0.004678768,
-0.019077558,
-0.027065698,
-0.01701004,
0.0041350373,
0.0031180598,
0.014606885,
0.019842809,
-0.01195536,
-0.0107672075,
-0.009444801,
-0.01444578,
-0.0139221875,
-0.00025781052,
0.0053164763,
-0.023709338,
0.01415042,
0.040759653,
-0.0421022,
0.007216177,
0.004920426,
-0.01121696,
0.005876989,
-0.018003523,
-0.021091375,
0.024662545,
0.017990097,
-0.0005810701,
-0.044089165,
-0.009236706,
-0.013009257,
-0.0024216147,
-0.017171144,
0.008216373,
-0.0012838083,
-0.008337202,
-0.013318042,
-0.010854473,
-0.009357536,
0.0060683014,
-0.013472435,
0.008075406,
-0.01188152,
0.01856739,
0.015398987,
0.025226412,
0.0203127,
0.0049640588,
-0.037698653,
-0.013197213,
-0.015157328,
0.008813805,
-0.004735826,
0.004651917,
-0.011572734,
-0.027763821,
-0.014284674,
0.01491567,
0.0039403685,
-0.0037188486,
-0.010881324,
-0.011371353,
0.019748831,
-0.0008701367,
-0.021507565,
-0.057407208,
-0.022621876,
0.00032095207,
-0.005235924,
0.012190305,
0.009760299,
-0.014230973,
0.013459009,
-0.017493356,
-0.011472044,
0.016580425,
0.011223673,
-0.007585377,
-0.029616533,
0.016687829,
0.00956563,
-0.018701646,
0.016620701,
0.020970546,
0.013284478,
-0.018312309,
0.026246747,
-0.011243811,
-0.03428859,
-0.011163258,
-0.030556316,
-0.026716636,
-0.004457248,
0.030932227,
0.017291974,
0.03286549,
-0.0022856821,
0.030744271,
0.01506335,
-0.015721196,
0.0123849735,
-0.010632953,
0.03069057,
0.009740161,
-0.02765642,
0.027871225,
0.0068268394,
0.00068931276,
0.021910328,
0.029643385,
-0.016311917,
0.007712919,
-0.028945262,
-0.011633148,
-0.015318434,
0.011055855,
-0.010438284,
0.013814784,
0.017520206,
0.007968002,
0.013552988,
0.0003054289,
-0.01136464,
0.0053433273,
0.016835509,
-0.0075988024,
0.015385561,
-0.005625262,
-0.015882302,
-0.013351606,
-0.012431963,
0.024581991,
-0.009511928,
-0.013311329,
0.012478952,
-0.008243224,
-0.0005177188,
0.005245993,
-0.022299666,
-0.017654462,
-0.009726736,
0.010364444,
0.007068497,
-0.0034604087,
0.007880737,
0.0147142885,
-0.01866137,
0.03850418,
-0.00046359742,
-0.016446171,
0.0018510333,
0.0026028582,
-0.006749643,
0.0070349337,
-0.000017437347,
0.03281179,
0.013425446,
-0.0042692916,
0.018621093,
-0.0060045305,
0.024447737,
-0.03453025,
-0.0018795624,
-0.0020356332,
-0.016352193,
0.014271249,
0.015492965,
0.032059964,
0.020433528,
0.0076726424,
-0.012217156,
0.0002724946,
-0.019802533,
0.008927922,
0.018312309,
0.026662936,
0.0071893265,
-0.02243392,
-0.016137386,
-0.019238664,
0.005917265,
0.001950046,
-0.0071356245,
0.028461946,
0.006222694,
0.01972198,
0.00963947,
0.019493748,
-0.0057997927,
-0.007686068,
-0.02635415,
0.033805273,
-0.0011738874,
-0.019158112,
-0.004457248,
-0.030341508,
0.008934634,
-0.013257627,
0.032033116,
0.011633148,
0.030744271,
0.014284674,
0.0047660335,
-0.0015489608,
0.00092719484,
0.009867703,
-0.03286549,
0.019520598,
0.0020859786,
0.028542498,
-0.014835117,
-0.0043397755,
-0.0053533968,
0.03853103,
0.0048801494,
0.0076927803,
0.0077397698,
-0.0091897175,
-0.005960898,
-0.017265124,
-0.0021161858,
0.0135597,
-0.026139343,
0.0057897237,
-0.001207451,
0.00044723516,
-0.002654882,
0.03850418,
0.011485469,
-0.013512711,
-0.03670517,
0.012814588,
0.005088244,
0.036678318,
-0.004762677,
-0.01272061,
0.03670517,
0.0011529102,
-0.005152015,
-0.024098676,
-0.024931053,
0.01594943,
-0.021789499,
-0.0055749165,
0.009089027,
0.0013668782,
0.0026045365,
0.016352193,
0.018621093,
0.0005923978,
-0.03458395,
0.000844964,
0.0018308952,
0.017547058,
0.020138169,
0.0008709758,
0.03316085,
0.012210443,
-0.016311917,
0.0056051235,
0.024595417,
0.008813805,
-0.022339942,
0.025051882,
0.025078733,
-0.00410483,
0.0059642545,
-0.015627218,
-0.027038848,
0.017197996,
0.014230973,
0.006518054,
0.012801163,
0.02154784,
0.0060213124,
0.020876568,
-0.0020826224,
-0.0026481692,
-0.020245573,
-0.022125134,
0.018715072,
-0.015855452,
-0.012143316,
0.009357536,
-0.020446954,
0.014606885,
-0.029106367,
0.0023544875,
-0.003715492,
-0.006622101,
0.0077599077,
0.002163175,
-0.02420608,
-0.0050278297,
-0.009767012,
-0.0091561545,
-0.00011831174,
-0.02243392,
-0.015278158,
-0.0037624813,
0.00022235895,
-0.01641932,
-0.009370961,
-0.001671468,
-0.024890777,
-0.034557097,
0.0017142616,
0.007712919,
0.0301267,
0.012170167,
-0.017318824,
0.016781807,
0.021762649,
0.007733057,
-0.02187005,
0.016056834,
-0.039363407,
-0.004598215,
0.009290408,
0.002200095,
-0.01235141,
-0.01927894,
-0.023897294,
0.016083684,
0.011747265,
0.031147035,
-0.008108969,
-0.0047224006,
0.0053936727,
0.022192262,
0.02561575,
0.006544905,
-0.011485469,
-0.0011008866,
-0.004819735,
-0.032919195,
-0.019896511,
-0.009082315,
-0.02172237,
0.00067337,
-0.006648952,
-0.019265516,
0.0054205237,
0.011606298,
-0.015546666,
0.0030912089,
0.018647945,
0.0010236902,
0.012062763,
0.00090873486,
0.031093333,
-0.0062730396,
-0.0024014767,
-0.01715772,
-0.010733644,
0.017788716,
-0.0033546833,
-0.020352976,
0.018715072,
-0.021319607,
-0.020661762,
-0.03283864,
-0.019950213,
-0.01627164,
0.05660168,
0.002191704,
-0.03646351,
-0.0010530584,
-0.010538975,
-0.0050110477,
-0.0056286184,
0.0047660335,
-0.004809666,
-0.022957513,
0.0038564594,
0.010364444,
-0.001559869,
-0.00078874495,
-0.038289372,
0.016634127,
0.04164573,
0.011277375,
0.013445584,
0.004131681,
-0.0048969314,
-0.0075249625,
-0.010585964,
0.007706206,
-0.051902775,
-0.0015909154,
0.0011294156,
0.038477328,
0.0115458835,
0.018876176,
-0.00571924,
-0.0012116465,
0.037859756,
0.036356106,
-0.0007593768,
0.008598998,
0.007833748,
-0.006340167,
0.007538388,
0.020124743,
0.003601376,
0.0060112434,
-0.039363407,
-0.004846586,
0.0060951523,
-0.019090984,
-0.031039631,
0.0005193969,
-0.017345676,
-0.033268254,
0.017828992,
-0.00784046,
0.008753391,
-0.021520989,
-0.016204514,
0.0053164763,
-0.013801359,
0.024313483,
-0.024595417,
0.020285849,
0.008572147,
0.024796799,
-0.012895141,
0.022272814,
-0.019829383,
-0.012049338,
-0.005950829,
-0.015936004,
0.021507565,
-0.0043599135,
0.023749614,
0.014459205,
-0.012096327,
-0.0006398064,
0.0029099653,
-0.0047425386,
-0.007578664,
-0.007068497,
-0.01986966,
-0.023924144,
-0.009558917,
-0.028408244,
-0.043283638,
-0.006407294,
0.013459009,
-0.007531675,
0.005870276,
-0.015640644,
-0.026058791,
0.022970937,
0.012203731,
0.021601543,
-0.0071826135,
0.014512907,
0.015143903,
-0.007968002,
-0.023803316,
-0.013358318,
0.018178053,
-0.010894749,
0.044679884,
0.02075574,
-0.013586551,
-0.0091897175,
0.013472435,
0.0046284227,
0.005115095,
-0.045378007,
0.015197605,
-0.01856739,
-0.0028327692,
-0.00086678035,
0.02007104,
0.0010924956,
0.008592285,
-0.0014314882,
0.015425838,
-0.010438284,
0.004427041,
-0.009793863,
0.013291191,
0.009411237,
0.017117443,
0.0049808403,
0.0023746258,
-0.02980449,
-0.029938744,
-0.0035543868,
-0.004292786,
-0.0090219,
0.011190109,
0.008786954,
-0.007954577,
0.013459009,
0.0036819286,
-0.0006511341,
-0.017426228,
-0.015291583,
0.0391486,
-0.011183396,
-0.013183787,
0.005813218,
-0.011753978,
0.007585377,
-0.009746874,
-0.0072564534,
0.000101529935,
-0.009411237,
-0.0035141103,
0.025119008,
0.0013895336,
0.00054373057,
-0.0031180598,
-0.017641036,
-0.007122199,
-0.016580425,
-0.021749223,
0.02544122,
-0.028676752,
-0.005796436,
0.0015120408,
0.033644166,
0.025521772,
0.014123569,
-0.005615193,
-0.01272061,
0.018473413,
-0.016217938,
0.020715464,
-0.01654015,
-0.020057617,
-0.014566609,
0.01624479,
-0.005544709,
-0.042612366,
0.025226412,
-0.03528207,
-0.02921377,
0.011727127,
-0.024716245,
0.019265516,
0.022890385,
-0.027481887,
0.016969763,
-0.002226946,
-0.0050949566,
-0.0059474725,
-0.012089614,
0.0203127,
-0.024917627,
0.0017419516,
0.006679159,
0.010659804,
0.008310351,
-0.006823483,
-0.0050043347,
0.0073907077,
-0.014512907,
-0.00571924,
-0.016848935,
0.0083640525,
-0.0028814364,
-0.0033379016,
0.016929487,
-0.00049464375,
-0.019023856,
0.0218432,
-0.005588342,
-0.011203535,
-0.032113668,
0.0064005814,
0.022635302,
0.013271053,
0.0078068967,
-0.0050479677,
-0.0052594184,
-0.01151232,
-0.03404693,
0.009471652,
-0.0075249625,
0.03734959,
0.014620311,
-0.007686068,
-0.016338767,
0.0044236844,
-0.040867057,
-0.023870442,
0.019198388,
0.02452829,
-0.0013198891,
0.012136603,
0.006128716,
0.0034906159,
-0.018822474,
-0.003324476,
0.006128716,
-0.023682486,
-0.004111543,
0.010948451,
-0.009122591,
0.005125164,
-0.038665283,
-0.018782198,
0.046774253,
-0.0030660362,
-0.03248958,
0.024957905,
-0.018124351,
0.02334685,
-0.021239055,
-0.011915083,
0.005319833,
0.01609711,
0.026582383,
-0.02768327,
-0.0044438224,
0.016674403,
-0.0025223056,
-0.031791456,
0.0017184571,
0.000278578,
0.014929096,
0.0008579699,
-0.0048432294,
0.0039403685,
0.0053936727,
-0.00722289,
0.005813218,
0.0027001929,
-0.00060876005,
0.02199088,
0.0070349337,
-0.025790282,
-0.03340251,
-0.025508348,
-0.005081531,
0.019560875,
0.019319216,
0.008525158,
-0.014338376,
-0.0019886442,
-0.009411237,
-0.031684052,
-0.01190837,
0.009089027,
-0.007612228,
-0.014633736,
-0.015345285,
-0.019480322,
0.008162671,
0.0017302043,
0.005923978,
-0.0027320783,
-0.0301267,
0.0010295638,
-0.0019920005,
-0.017963247,
0.027159678,
-0.00594076,
-0.006914105,
-0.01183453,
-0.0026716636,
0.009579056,
-0.02862305,
0.023158895,
0.18752663,
0.0038665284,
0.015613793,
0.011451906,
-0.0067899195,
-0.019842809,
0.01841971,
-0.01188152,
-0.023588508,
-0.003574525,
0.003910161,
0.022501048,
-0.0131032355,
0.0063569485,
0.017077167,
-0.03683942,
-0.028515646,
-0.0054003857,
-0.010518837,
0.012861577,
0.015291583,
0.0025659383,
-0.010713506,
-0.009854278,
0.04336419,
0.009793863,
-0.052171282,
0.016929487,
0.005598411,
0.013606689,
-0.043122534,
-0.011324364,
0.014392078,
0.0135597,
0.005366822,
0.008176097,
-0.01703689,
0.01535871,
-0.0026229965,
-0.0008969876,
0.005578273,
0.0034033505,
0.00039311385,
-0.008880933,
0.01580175,
0.005098313,
-0.020970546,
-0.017090593,
-0.016432745,
-0.0018141133,
-0.05482952,
0.026904594,
0.01819148,
0.040705953,
0.024581991,
0.00843118,
-0.015184179,
0.03520152,
0.006813414,
0.0123648355,
-0.021588117,
0.0032070035,
-0.011733839,
-0.011941934,
-0.024165802,
0.034503397,
-0.03130814,
0.0071826135,
0.014123569,
-0.012747461,
-0.004829804,
0.0011621402,
-0.02213856,
-0.003351327,
-0.016204514,
-0.01168685,
0.033912677,
0.013459009,
0.029455429,
0.021507565,
-0.0056756074,
-0.005950829,
-0.06197186,
-0.0018459988,
0.0065516178,
-0.059447873,
0.031872008,
-0.014660587,
-0.021507565,
-0.0123312725,
0.01363354,
-0.012908566,
-0.007867311,
-0.004930495,
0.018486839,
-0.010055659,
-0.028972112,
0.0015984671,
-0.010888036,
-0.039793022,
-0.04033004,
0.08184152,
0.008773529,
0.032086816,
-0.008216373,
0.018057225,
-0.008196235,
-0.008813805,
-0.001142002,
-0.020111319,
0.009122591,
-0.016634127,
0.03525522,
-0.017251698,
-0.01856739,
0.007068497,
0.03157665,
-0.022715854,
0.031791456,
-0.0099885315,
-0.015291583,
0.008995049,
-0.008323777,
0.018312309,
-0.022420494,
0.009572343,
-0.01210304,
0.006934243,
-0.007659217,
-0.020124743,
0.0034604087,
-0.002154784,
0.0067295046,
-0.004336419,
0.0123379845,
-0.021896902,
0.035416327,
0.0068033445,
0.016728105,
0.0027992055,
-0.0056051235,
0.008491594,
0.012995832,
0.012143316,
-0.004527732,
0.009626045,
0.04390121,
0.025226412,
-0.013814784,
-0.0047022626,
-0.025723154,
-0.027428186,
-0.0005328224,
-0.0017620898,
0.02016502,
-0.010283891,
-0.009901267,
-0.020258998,
0.004218946,
0.025843984,
-0.024461163,
0.0017385952,
0.019748831,
-0.02196403,
-0.01400274,
-0.0065650432,
-0.16883841,
0.0069610937,
0.017506782,
-0.03316085,
0.022514474,
0.010089222,
-0.007874024,
-0.0016236398,
0.0051755095,
-0.018647945,
0.0147142885,
0.011015578,
-0.044679884,
-0.043525297,
0.016714681,
0.020567782,
-0.009773725,
0.008075406,
0.029616533,
0.010142924,
0.03152295,
-0.034181185,
-0.013237489,
-0.029079515,
0.008176097,
0.015640644,
0.013217351,
-0.0390949,
-0.02487735,
-0.0011814393,
-0.016070258,
0.020433528,
0.025696304,
-0.0025374093,
0.025199562,
0.007196039,
-0.0061723487,
0.0013878555,
-0.010277179,
0.017587334,
0.031066481,
0.012525941,
-0.004682124,
0.022098284,
-0.013304617,
0.025427794,
0.019037282,
-0.011445193,
0.0011210247,
-0.0083909035,
-0.013271053,
-0.016029982,
-0.00142058,
0.003953794,
0.032946043,
0.018755348,
0.0021195423,
0.044679884,
0.0065482613,
-0.019560875,
-0.013385169,
-0.017788716,
0.03098593,
-0.0041618883,
0.027790673,
-0.0069275303,
-0.0013492573,
0.015452689,
-0.013774508,
0.012673621,
-0.028220287,
-0.020097893,
0.0034469832,
-0.0038564594,
0.023883868,
0.014888819,
-0.008833943,
0.025051882,
-0.0030559672,
0.0064844904,
-0.0014499482,
-0.0035308923,
-0.011210247,
-0.0123312725,
0.006081727,
-0.031066481,
0.010606103,
0.0076726424,
-0.006397225,
-0.0035946632,
0.022782981,
-0.010606103,
0.015143903,
0.0009364248,
0.021762649,
0.014230973,
0.0025004894,
-0.014754565,
-0.013042821,
0.009109165,
0.02561575,
-0.022420494,
0.010471848,
0.026568957,
0.014902245,
-0.0017771934,
-0.017936395,
-0.0032724524,
0.049459342,
0.004490812,
-0.006128716,
0.0018594243,
0.010928313,
0.027280506,
-0.01942662,
0.032328475,
-0.032919195,
-0.011270662,
-0.012210443,
-0.028086033,
0.06471065,
0.00015806365,
0.012948843,
0.013720806,
0.013432158,
-0.03533577,
-0.13994685,
-0.011472044,
0.008397616,
0.012935417,
-0.024971329,
0.01733225,
-0.0075182496,
0.042504963,
-0.0011428411,
0.015036499,
-0.031872008,
-0.009303834,
-0.013895337,
-0.0053231893,
-0.015345285,
0.00872654,
-0.0006683355,
-0.014110143,
-0.010431572,
0.036973678,
-0.010478561,
0.005152015,
-0.0046015717,
0.012116465,
0.015224456,
0.012673621,
-0.013546275,
0.00302576,
0.017104018,
-0.0002955696,
-0.016110536,
-0.0031801525,
0.0071826135,
0.005876989,
-0.030556316,
-0.015962856,
0.0043800515,
-0.027522163,
0.024756523,
-0.011780829,
0.018849326,
0.009015187,
-0.0062461887,
0.011619723,
0.0031365198,
-0.008323777,
-0.018231755,
0.0041350373,
-0.021400161,
-0.014687438,
-0.036007047,
-0.05321847,
-0.03670517,
-0.025602326,
0.031227587,
-0.005860207,
0.02225939,
0.031710904,
0.005152015,
-0.015573517,
0.011727127,
0.008404329,
-0.009377674,
0.015170754,
-0.0052762004,
-0.005524571,
-0.023064915,
-0.039229155,
0.021185353,
-0.03490616,
-0.0018090789,
-0.001894666,
0.0063200286,
0.010988727,
-0.026394427,
0.011968785,
-0.011948647,
-0.037161633,
-0.009874416,
-0.021682095,
0.000016847362,
-0.023454254,
0.0115056075,
-0.02391072,
0.028676752,
0.004645204,
0.00700137,
-0.0019567588,
0.00674293,
-0.024863927,
0.004057841,
0.011492182,
-0.012995832,
-0.017869268,
0.0052795564,
0.008793667,
-0.007404133,
-0.019856235,
-0.002599502,
0.011210247,
-0.0083506275,
-0.011975498,
-0.043766953,
0.01703689,
-0.007122199,
-0.010874611,
0.011169971,
-0.027951779,
0.021453863,
-0.004863368,
-0.013566413,
0.02119878,
-0.028435094,
0.00872654,
0.003806114,
0.01059939,
-0.03522837,
-0.018204905,
0.034422845,
-0.013606689,
0.03888009,
0.02378989,
-0.010290604,
0.022984363,
-0.010357732,
0.02352138,
-0.0020289205,
-0.012713897,
-0.018862752,
0.0026599164,
-0.014405504,
-0.0203664,
-0.0071826135,
-0.012311134,
-0.031227587,
0.006776494,
-0.00597768,
-0.0018258606,
0.005326546,
0.05209073,
0.019064134,
0.01609711,
-0.013593264,
-0.03882639,
0.0056051235,
0.012626632,
0.003601376,
0.020675186,
-0.04118927,
-0.0083841905,
0.019144686,
-0.011190109,
0.029992446,
0.015936004,
-0.015439263,
-0.009008475,
-0.023588508,
0.00068218046,
0.0022051295,
-0.017654462,
-0.014324951,
-0.009203143,
0.009901267,
0.016620701,
-0.010733644,
-0.015868876,
0.004188739,
0.0026162837,
-0.02007104,
-0.007874024,
0.0013844991,
-0.018486839,
-0.035067264,
0.014204122,
0.012015774,
-0.013814784,
0.020849718,
-0.007894162,
-0.039551362,
-0.006974519,
-0.012472239,
0.02243392,
0.014432354,
0.013042821,
0.016593851,
0.012915279,
0.022474196,
0.008008279,
0.0045411573,
0.018312309,
0.0003970995,
-0.0016076971,
-0.014392078,
0.023132043,
0.007968002,
0.012989119,
0.00729673,
0.010485273,
-0.020003915,
0.007477973,
-0.0038698849,
0.012881716,
0.01939977,
0.009109165,
0.011042429,
-0.024461163,
-0.016338767,
0.018929878,
-0.020675186,
-0.015842026,
-0.0029384946,
-0.010384582,
-0.0044337534,
0.0025927892,
0.00843118,
0.0091561545,
-0.01895673,
0.009995244,
-0.027159678,
-0.02366906,
-0.020796016,
0.011599585,
0.015090201,
0.029723937,
-0.0049070003,
0.0020490587,
0.0027052274,
0.011384778,
0.021145077,
-0.025065307,
0.026958296,
-0.010330881,
0.00028508095,
-0.012237294,
-0.030932227,
-0.002701871,
-0.011995636,
-0.00443711,
-0.012774312,
-0.0011034039,
-0.02137331,
0.0812508,
0.020567782,
-0.014056441,
0.013042821,
-0.017708164,
0.039954126,
-0.012539366,
0.018862752,
-0.038718987,
-0.015170754,
0.002525662,
-0.017560484,
0.01745308,
-0.029294323,
0.004853299,
0.025427794,
0.0019752188,
0.041001312,
-0.0058837016,
-0.016942913,
0.0042021647,
0.00685369,
0.007686068,
0.013841635,
-0.026206471,
0.00024081893,
0.047848288,
0.007202752,
0.012217156,
-0.044357672,
0.008887645,
-0.004356557,
-0.029401727,
0.010384582,
0.0068637594,
0.008645987,
-0.010022095,
-0.002154784,
0.027549015,
0.015868876,
0.009558917,
-0.023440829,
-0.017144294,
-0.024286631,
-0.0017587334,
0.006850334,
-0.016701255,
0.011371353,
-0.01880905
] |
Although drugs are a common cause of acute immune-mediated thrombocytopenia in adults, the drug etiology is often initially unrecognized. Most cases of drug-induced thrombocytopenia (DITP) are caused by drug-dependent antibodies that are specific for the drug structure and bind tightly to platelets by their Fab regions but only in the presence of the drug. A comprehensive database of 1301 published reports describing 317 drugs, available at www.ouhsc.edu/platelets, provides information on the level of evidence for a causal relation to thrombocytopenia. Typically, DITP occurs | [
-0.01373523,
-0.003334786,
-0.0026799669,
-0.041550666,
-0.02587334,
0.041397344,
-0.014706279,
0.00306647,
-0.019472085,
0.014604063,
0.010253509,
0.01112873,
0.0096721575,
-0.0008033512,
-0.01659727,
0.027802661,
0.030613592,
0.012163664,
-0.022206353,
-0.013134713,
-0.034216695,
0.01549845,
0.008317799,
0.00062008173,
-0.002842873,
0.015268465,
0.012604469,
-0.05205333,
-0.028467063,
0.009339957,
0.0031191749,
-0.019050444,
-0.013990769,
-0.0095379995,
0.015524004,
-0.011499262,
-0.0022471475,
0.0028700242,
-0.010394055,
0.0128600085,
0.00088799855,
0.026499411,
0.008247526,
0.010687926,
0.016661154,
0.009416618,
0.025247268,
0.021145865,
-0.029157018,
0.019127106,
0.031635746,
0.004880798,
0.021414181,
-0.012968613,
0.011697305,
-0.039250813,
0.0030345276,
0.016891139,
0.013083605,
-0.02192526,
-0.004775388,
-0.013198597,
-0.008413627,
0.0060498896,
-0.014642394,
-0.0143613005,
0.013875776,
0.026320534,
0.008643612,
-0.005637833,
0.037666474,
0.014412409,
0.0036062964,
-0.023573488,
0.025170607,
-0.021733606,
-0.019804286,
-0.00016919487,
-0.009812703,
0.018820459,
0.022423562,
-0.008931094,
-0.019254876,
0.008867209,
-0.002973837,
-0.008835266,
-0.008349742,
0.023931243,
0.02113309,
0.0056538037,
-0.0010461134,
0.0137096755,
-0.0063405656,
0.018117726,
-0.00033439696,
0.024557313,
0.02062201,
0.045383755,
-0.024493428,
-0.029105911,
0.00052026176,
0.0057017175,
-0.01209339,
-0.01692947,
-0.03692541,
0.013990769,
-0.013518021,
-0.0022583273,
-0.010215178,
-0.003147923,
-0.014936264,
0.03856086,
0.010138516,
-0.05703634,
0.008637223,
0.012604469,
0.013390252,
0.0034721384,
-0.003561577,
-0.03868863,
0.016993355,
0.023777919,
0.014974595,
-0.014092985,
0.027674891,
-0.005669775,
-0.01415687,
-0.013351921,
0.013645791,
0.0057943505,
0.016137298,
0.009857423,
-0.024825629,
-0.02596278,
-0.015255688,
0.0017967598,
-0.03140576,
-0.033654507,
-0.0055420054,
-0.012738627,
0.000880013,
0.02759823,
-0.016750593,
-0.0068228957,
0.0074489666,
0.03150798,
0.00305529,
0.013914107,
0.005561171,
-0.005934897,
-0.013645791,
-0.015958421,
0.012355318,
-0.021656943,
-0.019382644,
0.02473619,
-0.00974243,
-0.014105761,
-0.007883383,
-0.0048105246,
0.002213608,
0.008177253,
0.018015511,
-0.023777919,
0.030766916,
0.021720828,
-0.022551332,
0.0028173192,
0.01029184,
-0.004938294,
-0.013530798,
0.019535968,
0.005411042,
0.00514592,
0.014080208,
0.013249706,
-0.00861167,
0.0054877033,
-0.021248082,
-0.018846013,
-0.0012018327,
-0.00096226466,
0.03263235,
0.009103582,
-0.005337574,
-0.0029914053,
0.019868169,
0.0024595645,
-0.012112556,
-0.025030062,
0.0017025296,
0.023650149,
-0.0061169686,
-0.023995128,
-0.64191437,
-0.01209339,
0.02851817,
-0.0062766806,
0.014731833,
0.02923368,
0.029208126,
0.01722334,
-0.033168983,
0.032453474,
-0.01344136,
0.027751552,
-0.004107792,
0.0011443363,
-0.00504051,
-0.012764181,
-0.010093797,
-0.010336559,
0.007372305,
0.010841249,
-0.007762002,
-0.0010349336,
-0.008349742,
0.015485673,
0.022960193,
-0.030511376,
0.02469786,
-0.0071550966,
0.0037117063,
0.023790697,
-0.0116909165,
0.029591436,
0.024915067,
0.00074106356,
0.05121005,
-0.0029387004,
0.008471123,
0.018679913,
-0.00474664,
0.014246308,
-0.015983975,
0.0027087152,
0.016661154,
-0.007825887,
0.0082411375,
0.0038778067,
-0.003079247,
0.013428583,
0.00018616427,
0.01314749,
0.0023493632,
0.008681943,
-0.032197934,
0.018641582,
0.021618612,
0.02205303,
0.009129137,
-0.0053407685,
-0.0041684825,
-0.011409824,
-0.0051938333,
0.0019836228,
0.0051299487,
-0.010643206,
0.004507072,
-0.0025617802,
-0.020890327,
0.010253509,
0.007966434,
-0.02583501,
0.027751552,
0.011940068,
0.014578509,
-0.028492616,
0.02708715,
0.009665769,
0.005391876,
0.008388073,
-0.024685083,
-0.0004815316,
-0.010221566,
0.011588701,
-0.024978952,
0.0027773913,
0.06347593,
0.007123154,
-0.003334786,
0.020673119,
-0.0058071273,
-0.010138516,
0.00785144,
0.022346899,
-0.019765954,
-0.03150798,
-0.016725037,
0.020059824,
0.0053024376,
0.00007117165,
0.00552284,
-0.00405349,
-0.020430356,
-0.02457009,
0.0030441103,
0.012355318,
0.02016204,
0.006043501,
-0.038995277,
-0.011052068,
0.055094242,
-0.006254321,
0.030434715,
0.0054845093,
-0.00076142687,
-0.015843429,
0.016827254,
-0.009563553,
0.0029914053,
0.00701455,
0.0040375185,
-0.013211374,
0.0052609127,
0.027981538,
0.011556759,
-0.009857423,
-0.011154285,
0.008790547,
0.0050884234,
-0.008311411,
0.00405349,
-0.02721492,
0.0065992987,
-0.0059668394,
0.044080507,
0.006490695,
0.031814627,
-0.0042355615,
0.02394402,
0.017402217,
-0.0067526223,
-0.022947416,
-0.02994919,
-0.016303398,
-0.0103876665,
0.013109159,
0.0008911928,
0.0039001664,
-0.012074226,
0.019944832,
-0.0033795054,
-0.0088224895,
0.027674891,
0.00030225492,
0.009767984,
0.03334786,
0.018258274,
-0.008835266,
-0.011480097,
-0.018322159,
-0.0010636818,
-0.017606648,
-0.005829487,
0.028620386,
0.019804286,
-0.0022695072,
-0.010898746,
-0.029003695,
0.0041397344,
-0.0028875924,
-0.0076470096,
-0.034625556,
0.01478294,
-0.018833237,
-0.0058486527,
0.025208939,
-0.028364846,
0.02225746,
-0.008503065,
-0.0070528807,
-0.014885156,
0.008835266,
-0.027649337,
-0.02306241,
-0.0034849152,
0.0053790994,
0.033424523,
-0.013479691,
0.009557164,
0.010802918,
-0.0071167657,
0.06276042,
-0.005014956,
0.005791156,
-0.0026943411,
0.0013383863,
-0.016392836,
-0.016098967,
0.01650783,
0.025030062,
-0.012074226,
0.04351832,
0.019919278,
-0.0022631187,
0.023573488,
-0.013403029,
0.01755554,
-0.024148451,
-0.0007418621,
-0.016712261,
0.021426959,
0.007985598,
-0.00928246,
-0.0035008865,
-0.009269683,
-0.021120312,
-0.0030393188,
0.0039800224,
-0.009269683,
-0.003240556,
-0.0013056454,
-0.00672068,
0.0055452,
0.0023717228,
0.057138555,
-0.0074489666,
0.0050884234,
0.0012074226,
0.030255837,
-0.006190436,
0.01810495,
-0.020481464,
-0.035187744,
-0.02541337,
0.016290622,
-0.0077428366,
-0.017581094,
0.01814328,
-0.01843715,
-0.0065545794,
0.031865735,
0.011793132,
0.008796936,
-0.00054022577,
0.011275666,
-0.0037308717,
0.023509603,
-0.010943465,
0.025720017,
0.0055036745,
-0.0070337155,
0.035519943,
0.0050756466,
0.017619425,
-0.026652735,
-0.00978715,
-0.016277844,
0.008247526,
0.0043154177,
0.014105761,
0.04448937,
0.02444232,
0.025208939,
0.00016620028,
-0.001787177,
-0.01659727,
0.02747046,
0.0039512743,
0.014770163,
0.0006412436,
-0.0046987263,
0.011601478,
-0.04523043,
-0.014271862,
0.013466914,
-0.020507017,
0.013262482,
-0.0025266435,
-0.0012194009,
0.02058368,
0.007372305,
0.011454543,
-0.000155819,
-0.044566028,
0.00017149073,
0.030179175,
-0.0051810564,
-0.024544537,
-0.018769352,
-0.033807833,
-0.0083050225,
0.007257312,
0.0035168577,
0.0005474128,
0.01373523,
0.028364846,
0.00031123872,
-0.036644317,
0.035468835,
-0.013888554,
0.006733457,
-0.0076789516,
0.008701108,
-0.029846974,
-0.018219942,
-0.009678545,
0.01604786,
0.0012649188,
0.00057935517,
-0.024327328,
-0.019395422,
-0.0025314349,
0.02016204,
0.0043537486,
-0.0075831246,
-0.027777107,
-0.006065861,
0.03580104,
-0.015907314,
0.030639146,
0.0057272715,
-0.014476294,
-0.015383458,
-0.019127106,
-0.0050213444,
-0.028697047,
0.018948229,
0.018296603,
-0.0046987263,
0.017606648,
-0.03804978,
0.011895348,
-0.0082411375,
-0.027444907,
0.04443826,
-0.010259897,
0.001313631,
-0.0060051703,
0.025771124,
0.0042227847,
-0.0018223136,
0.031916842,
-0.0023493632,
-0.008624447,
-0.005478121,
0.006378896,
0.0032565272,
0.0001912551,
0.02264077,
0.02326684,
0.010489883,
-0.010739033,
0.006174465,
0.021938037,
0.010790141,
0.011857017,
-0.020851996,
-0.0036733754,
-0.0221808,
0.024544537,
-0.009557164,
-0.03712984,
-0.004551791,
0.021708053,
0.013620237,
0.024582867,
0.010949853,
0.011211781,
0.007187039,
-0.010311005,
-0.012943058,
-0.0137735605,
0.017581094,
0.0020746586,
-0.000014299213,
-0.038254213,
0.0028189165,
0.02385458,
-0.0073531396,
-0.027547121,
-0.008618059,
0.004283475,
0.010464328,
-0.025375038,
-0.01415687,
-0.022129692,
0.0038490586,
-0.021069204,
-0.0053120204,
-0.012515031,
-0.01843715,
-0.019510414,
-0.021938037,
-0.014399632,
-0.014016323,
-0.006988996,
-0.0037564256,
-0.002307838,
-0.021580283,
0.012687519,
0.00017747993,
0.0022024282,
0.0035583829,
-0.01050266,
-0.00073786936,
0.03419114,
-0.022794094,
-0.0067398455,
-0.00072988373,
-0.03158464,
-0.006493889,
0.009531611,
-0.00061209616,
-0.013390252,
-0.007417024,
0.038790844,
-0.0026751757,
-0.0011698902,
-0.008279469,
0.0033954766,
0.010719867,
-0.0058486527,
0.0062127956,
0.02734269,
-0.016852807,
0.011135119,
-0.0030377218,
-0.019868169,
-0.015319573,
-0.025221715,
0.00785144,
0.0010700702,
-0.00573366,
-0.013198597,
0.008924705,
-0.004804136,
0.0111031765,
0.004146123,
-0.014220755,
0.017402217,
0.03431891,
0.022909086,
0.00098143,
0.008138922,
0.020481464,
-0.028339293,
-0.011135119,
-0.0013120339,
0.01621396,
0.0010389264,
-0.008522231,
0.01461684,
0.017414995,
-0.031175777,
-0.027700445,
-0.024621198,
0.008707497,
0.013083605,
0.01255975,
0.012029506,
-0.038535304,
0.015536781,
-0.021120312,
0.0048744096,
0.014271862,
-0.018130504,
0.00017458515,
0.0040215477,
-0.016776146,
-0.002360543,
0.017874964,
-0.032402366,
0.0039959936,
-0.0069187228,
-0.0143613005,
-0.013799115,
-0.003175074,
0.011448154,
-0.032785673,
0.0019804286,
-0.009831869,
-0.03953191,
-0.025068391,
-0.0026863555,
0.01583065,
0.03557105,
0.040758494,
0.00088320725,
0.021516398,
0.012163664,
-0.020213148,
0.028697047,
-0.009831869,
0.00027590245,
-0.014897933,
-0.0043920795,
0.0009894157,
-0.008017541,
0.022014698,
-0.017964402,
0.014067431,
0.016942246,
-0.018449927,
-0.016431168,
0.011722859,
-0.034472235,
0.010272674,
0.012566138,
0.008471123,
0.04144845,
-0.027444907,
-0.010419609,
0.0060690553,
-0.0031830596,
0.012834454,
0.00642681,
0.015932867,
-0.009978804,
0.020264255,
-0.005989199,
-0.00030145634,
-0.016942246,
-0.014246308,
0.00065841264,
-0.019842615,
0.026857166,
0.023650149,
-0.00066000974,
0.00247873,
0.0018606446,
-0.020494241,
0.018743798,
-0.0047721937,
-0.008937482,
0.0058742063,
-0.017478878,
-0.00730842,
0.0063341768,
-0.02734269,
-0.0071550966,
-0.008618059,
-0.0026096937,
-0.029284788,
0.0038235048,
-0.009333568,
-0.031865735,
0.008809713,
-0.030332498,
0.0069506653,
-0.027828215,
0.04203619,
0.02961699,
-0.0006368515,
0.01797718,
0.00010096791,
-0.017593872,
-0.010477105,
0.0169678,
0.024927845,
-0.008036707,
-0.01650783,
-0.0035903251,
0.011345939,
-0.033782277,
-0.028109308,
0.022551332,
-0.0056218617,
-0.0055004805,
-0.015217357,
-0.011537593,
-0.022857977,
0.007027327,
-0.012840843,
0.00861167,
0.014667948,
-0.019267652,
-0.010675148,
-0.00068316795,
-0.014412409,
0.025528362,
-0.010023523,
-0.000373726,
-0.00055619696,
-0.0072892546,
-0.013658568,
-0.010170459,
-0.013160267,
0.0032102107,
0.012661966,
0.004657201,
0.0043824967,
-0.007480909,
0.013862999,
-0.006605687,
-0.013185821,
0.042956132,
0.017376663,
0.0072445353,
0.031686857,
-0.01277057,
-0.009793539,
-0.023995128,
-0.014808495,
-0.0066184644,
-0.029668096,
0.0029961967,
0.025349485,
-0.0064300043,
-0.015945643,
0.028952587,
-0.032197934,
-0.010157682,
-0.007928102,
-0.017568318,
0.025030062,
-0.030485822,
-0.007940879,
-0.0022471475,
0.0055004805,
-0.018117726,
-0.0031191749,
0.0003341973,
0.011895348,
0.008017541,
-0.0151406955,
0.0023094353,
0.005177862,
0.022653546,
-0.042956132,
-0.017670533,
-0.016725037,
-0.015421788,
0.00785144,
0.008177253,
-0.031635746,
-0.012412814,
-0.0038203103,
-0.004644424,
0.010112963,
-0.020928657,
0.044923786,
-0.012745015,
0.030613592,
-0.010394055,
-0.018194389,
0.016610045,
-0.019880947,
0.02020037,
0.009531611,
-0.005829487,
-0.046635896,
0.0077045057,
0.009659381,
-0.0036382389,
-0.02398235,
0.00012906724,
-0.018168835,
0.027444907,
-0.011997564,
-0.007218981,
0.0033156206,
0.010496271,
-0.011020127,
-0.0074872975,
0.004011965,
-0.009851035,
-0.012917505,
0.0029259233,
0.001560386,
-0.0013695302,
0.006350148,
0.01033017,
-0.012163664,
-0.013428583,
-0.025298377,
0.0032213905,
-0.010783752,
0.019012114,
-0.0139652155,
-0.0033826996,
-0.016916692,
-0.0058454582,
-0.031226885,
-0.0035296346,
0.008119757,
0.006401256,
0.013875776,
0.005970034,
0.00017438551,
0.009122748,
-0.0004615676,
0.0040439074,
-0.0088927625,
-0.0069123344,
0.0144890705,
0.0009446963,
0.0126683535,
0.006273486,
-0.037359826,
-0.007902549,
0.014770163,
-0.00886082,
0.011064846,
0.009652992,
0.013262482,
0.009780762,
-0.0044240216,
0.0122722685,
-0.01982984,
-0.0041205687,
0.008681943,
-0.022078583,
-0.01726167,
-0.0035008865,
0.0012784944,
-0.03235126,
0.017504433,
0.014731833,
0.002039522,
-0.012776958,
-0.04431049,
-0.014259085,
-0.007442578,
-0.025592247,
0.027291583,
-0.0025394205,
-0.009250518,
0.0046795607,
-0.0089566475,
-0.0018063424,
-0.02629498,
0.0033858938,
-0.011601478,
-0.008854432,
0.013556353,
-0.01865436,
0.003992799,
0.015153472,
0.008247526,
-0.025643354,
0.018616028,
0.008138922,
-0.00365421,
-0.02759823,
0.021363074,
0.015741212,
0.020800889,
0.0139013305,
-0.020443132,
-0.02708715,
-0.020289809,
-0.009129137,
0.019229323,
-0.020098155,
-0.01839882,
0.00015621827,
-0.021286411,
-0.009589107,
-0.0055579767,
-0.0028412761,
-0.037385378,
0.018846013,
0.1820461,
0.002465953,
0.014092985,
0.0047530285,
0.0076597864,
-0.015051257,
0.017913295,
-0.010572933,
-0.00525133,
-0.0028189165,
0.039046384,
0.013811892,
-0.012661966,
-0.0018015511,
-0.010208789,
-0.010860414,
-0.04116736,
-0.020417579,
0.001932515,
-0.01432297,
-0.02150362,
0.0029291175,
0.009384676,
0.021069204,
0.0173,
0.02221913,
-0.0014677531,
0.010898746,
0.026678288,
0.010937076,
-0.013428583,
0.0015699688,
0.0055963076,
-0.003373117,
0.0059923935,
-0.0036350447,
-0.012955835,
-0.0221808,
-0.0005266502,
-0.0034274189,
-0.0073850816,
0.018705467,
-0.017529987,
-0.014437962,
-0.0014749401,
0.026192764,
-0.013351921,
-0.042215068,
0.0054461784,
0.008752217,
-0.013671345,
-0.021950813,
-0.0035807425,
0.013288036,
0.025477255,
-0.008899151,
0.019242099,
0.0065673566,
-0.019433754,
-0.00581671,
-0.0027119094,
0.00543979,
-0.021324743,
0.014808495,
-0.017376663,
0.03230015,
-0.0065673566,
0.004027936,
0.007576736,
-0.0101257395,
0.0057560196,
-0.008541397,
-0.0086947195,
0.026154432,
-0.0059668394,
-0.035008866,
0.014540179,
0.026320534,
0.0037149005,
0.0065418025,
0.012297822,
0.020008717,
-0.013006943,
0.007832276,
-0.0093463445,
-0.02759823,
0.01533235,
0.0025953196,
-0.032785673,
0.022142468,
0.00080534763,
-0.02175916,
-0.01915266,
0.01873102,
0.022768538,
0.0076342323,
0.0067526223,
-0.0012369693,
0.00017498444,
-0.004695532,
-0.018909898,
0.0978715,
0.015894536,
0.02557947,
-0.020864772,
0.0226791,
-0.018488258,
0.010655983,
0.0003970839,
-0.016277844,
-0.017926073,
-0.026128879,
0.0083050225,
-0.003481721,
-0.024199558,
0.028952587,
-0.006497083,
0.0024994924,
0.013339144,
0.005666581,
0.00007202012,
-0.024595644,
0.034906648,
0.020213148,
-0.004657201,
-0.0006811716,
-0.014795718,
0.0064747236,
0.0044336044,
-0.024927845,
-0.027904876,
0.0038011451,
0.008407238,
-0.009161079,
0.0022695072,
0.015945643,
0.012834454,
-0.011192615,
-0.0045102662,
0.0197404,
-0.0020970183,
-0.006538608,
0.024071788,
-0.0029418946,
0.0007861822,
-0.01575399,
0.008087815,
-0.0030680671,
-0.029898081,
-0.0067142914,
-0.0044112448,
-0.016073413,
0.006490695,
-0.0034178363,
0.035341065,
-0.01112873,
0.002440399,
-0.014259085,
-0.007749225,
0.022985747,
-0.030128067,
0.03212127,
0.03296455,
-0.005174668,
-0.005430207,
-0.004283475,
-0.15782098,
0.010834861,
0.007749225,
-0.005375905,
0.04985569,
0.011026515,
0.02016204,
0.0076789516,
0.008215584,
-0.0032964551,
0.029335896,
-0.005072452,
-0.011211781,
-0.0074872975,
0.007819498,
-0.0021225722,
-0.022832423,
0.01948486,
0.044259384,
0.022231907,
0.027521567,
-0.0055292286,
0.033245645,
-0.028927034,
0.0066376296,
0.022768538,
0.03385894,
0.012304211,
0.004484712,
-0.015281241,
-0.02465953,
-0.009109971,
0.018999336,
0.0058071273,
-0.01075181,
-0.011013738,
0.0066376296,
-0.006644018,
0.0137735605,
0.013492468,
0.024276221,
0.009161079,
0.012815289,
-0.013492468,
-0.011352328,
0.022001922,
0.011205392,
-0.020353694,
0.026103325,
0.0021497232,
0.03086913,
0.0064779175,
-0.021695275,
0.019050444,
0.0077045057,
0.010234344,
0.0008872,
0.009761596,
0.014897933,
0.00053263945,
-0.005976422,
-0.016035082,
0.03922526,
-0.01650783,
-0.0004515856,
-0.032453474,
-0.010617652,
0.008336965,
-0.0247873,
0.03641433,
-0.010119351,
-0.011262888,
-0.004123763,
-0.001527645,
0.01915266,
0.032146826,
-0.029540326,
0.0011123939,
-0.0068165073,
-0.002026745,
-0.013339144,
0.015115141,
-0.018539365,
-0.024544537,
-0.02322851,
0.005986005,
0.0076470096,
0.010176847,
0.0017264865,
-0.0280582,
0.00012457534,
-0.027496014,
-0.0061137746,
-0.02205303,
0.00040526915,
0.02877371,
-0.012866396,
0.02310074,
0.011109565,
0.0036478215,
0.015191803,
-0.012323376,
-0.007480909,
0.0013000555,
0.009423006,
0.001213811,
0.017926073,
-0.0077172825,
0.026422748,
0.0110904,
0.010770976,
0.029872527,
0.0047146976,
0.008279469,
-0.026218317,
0.010349336,
0.010029912,
-0.0004176468,
-0.010604875,
-0.017542763,
0.06424254,
0.015281241,
-0.010119351,
0.053867657,
-0.025809456,
0.001133955,
-0.12644078,
-0.011480097,
0.020264255,
-0.0045645684,
0.006267098,
-0.0017680116,
-0.005669775,
0.0020922269,
0.016584491,
0.00008928897,
-0.0040055765,
-0.012917505,
-0.01579232,
-0.022372454,
0.011294831,
0.026013887,
-0.00039648497,
-0.01638006,
-0.027751552,
0.0391486,
-0.012566138,
-0.00018895922,
0.012035894,
-0.005494092,
-0.003532829,
-0.004162094,
-0.0030632757,
0.028415954,
-0.013811892,
0.022704655,
0.0005785566,
0.003695735,
0.006746234,
0.011857017,
-0.022717431,
0.00052225817,
-0.017862188,
-0.019855393,
0.045179322,
-0.026524965,
0.003452973,
0.0107134795,
0.014885156,
0.00421959,
0.0144890705,
-0.015242911,
-0.046073712,
0.0007738045,
0.02074978,
-0.014105761,
-0.00957633,
-0.026218317,
-0.042777255,
-0.015971197,
-0.0014461919,
-0.00043162162,
0.00739147,
0.017874964,
-0.02385458,
0.009544387,
-0.0044080503,
-0.026192764,
-0.00861167,
0.00394808,
0.014795718,
-0.008969424,
-0.013249706,
-0.014450739,
0.026550518,
-0.02486396,
-0.004692338,
-0.04678922,
-0.024621198,
0.007442578,
-0.028211523,
0.008126145,
-0.0023381833,
-0.010106574,
-0.002895578,
-0.00751924,
-0.009531611,
-0.008586116,
0.003599908,
0.022896308,
0.03145687,
0.03498331,
0.019510414,
0.008113368,
-0.0053567397,
-0.0072125928,
-0.019203767,
0.019063221,
-0.00001715656,
-0.012891951,
0.008075037,
0.024084566,
-0.009646603,
-0.023420164,
0.017172232,
0.015242911,
-0.0009534805,
-0.050085675,
-0.043416105,
0.016814476,
0.0121444985,
0.017248893,
0.021950813,
-0.018002734,
0.011671751,
-0.011294831,
0.008336965,
0.022883533,
-0.035085525,
0.0057272715,
-0.013070828,
0.010790141,
-0.03184018,
-0.015421788,
0.025515584,
0.019127106,
0.016290622,
0.0015971197,
-0.019689292,
0.0018734215,
0.008701108,
0.03301566,
0.020110931,
-0.0028412761,
-0.0012441563,
0.02675495,
-0.0128089,
0.02313907,
0.0031399375,
-0.054787595,
-0.0040822383,
-0.01860325,
-0.03288789,
-0.021823045,
-0.0008568547,
0.01885879,
0.023049632,
0.019714845,
-0.00025114708,
-0.023829026,
0.020979766,
-0.030690253,
-0.008036707,
-0.022372454,
-0.04351832,
0.014540179,
0.006605687,
-0.002988211,
0.029131465,
-0.0029562686,
-0.007199816,
-0.03086913,
-0.052845497,
0.018973783,
0.0050373157,
-0.011812298,
-0.0027933624,
-0.005308826,
-0.0027566287,
-0.012016729,
-0.014092985,
-0.032734565,
0.018807683,
-0.017057238,
-0.032453474,
0.0006528227,
0.016955024,
0.014565732,
-0.018501036,
0.0011818686,
-0.0038778067,
0.0041014035,
0.019293206,
0.0113651045,
-0.026703842,
0.012400038,
-0.010259897,
0.013977992,
-0.00902692,
-0.0058230986,
-0.030485822,
0.0037915623,
0.022960193,
-0.016891139,
-0.0038298932,
0.028467063,
-0.010394055,
-0.0013591489,
-0.017887741,
-0.0022040252,
-0.006682349,
0.03263235,
0.0010421206,
0.028748157,
-0.003679764,
0.015728435,
-0.0013447748,
0.0420873,
0.020519795,
0.014808495,
0.021733606,
-0.01735111,
0.007174262,
0.011020127,
-0.024633976,
-0.0365421,
-0.020251479,
0.008471123,
0.01617563,
0.01735111,
-0.00006962444,
-0.0013439762,
-0.025272824,
0.011052068,
-0.024518982,
0.020123709,
-0.0016833643,
0.01415687,
0.002507478,
0.020826442,
-0.007902549,
-0.00640445,
0.039123047,
-0.003813922,
0.012661966,
-0.014936264,
0.025145054,
0.011729248,
0.005149114,
-0.013888554,
-0.0283904,
-0.005267301,
0.00024455896,
-0.021605836,
0.012681131,
0.020251479,
0.002734269,
0.07686618,
-0.0037308717,
-0.013633015,
0.0013311993,
-0.013390252,
-0.016622823,
-0.002616082,
-0.00021201765,
-0.008637223,
-0.014374078,
0.009825481,
0.0032437502,
0.020136487,
-0.0391486,
-0.016035082,
0.007174262,
-0.0021401404,
-0.004427216,
-0.003122369,
-0.007819498,
0.002842873,
-0.009665769,
0.012463923,
0.016903916,
0.0005585926,
0.01222116,
0.010196012,
-0.0339356,
-0.018092172,
-0.05427652,
-0.0140291,
-0.007040104,
-0.01970207,
-0.015345126,
0.010630429,
-0.011952844,
-0.027828215,
-0.017670533,
0.008394461,
-0.012923893,
-0.033654507,
0.046610344,
-0.03431891,
-0.01755554,
-0.0007706103,
-0.023956796,
-0.028007092,
-0.020545349,
-0.01830938
] |
The marginal costs and benefits of converting malaria programmes from a control to an elimination goal are central to strategic decisions, but empirical evidence is scarce. We present a conceptual framework to assess the economics of elimination and analyse a central component of that framework-potential short-term to medium-term financial savings. After a review that showed a dearth of existing evidence, the net present value of elimination in five sites was calculated and compared with effective control. The probability that elimination would be cost-saving over 50 years ranged from 0% to 42%, with only one site achieving cost-savings in the base case. These findings show that financial savings should | [
0.002983798,
-0.009213597,
0.015440077,
-0.025582999,
-0.0063393265,
0.021321379,
-0.015041795,
-0.033853993,
-0.03887235,
-0.0025871752,
-0.008609535,
0.032845013,
-0.0029140988,
0.021215169,
0.00063351775,
0.019529108,
0.038898904,
-0.023950042,
0.0022419973,
0.0025324116,
-0.042828623,
0.0033422522,
-0.013249524,
-0.014696617,
-0.0042483443,
0.0032858287,
0.009094113,
-0.010972677,
-0.010720432,
0.0061235903,
0.010966039,
-0.015081623,
-0.00571867,
0.00096583454,
-0.03170327,
0.00031281754,
0.01850685,
0.008815315,
0.028809085,
-0.011855536,
0.01623664,
0.023950042,
-0.0045736083,
0.011278027,
0.012572444,
0.027614238,
0.029021502,
0.010421719,
-0.027215956,
0.014656788,
-0.00038562852,
0.02615387,
-0.025503343,
0.008124959,
-0.031862583,
-0.0008944756,
-0.011497082,
-0.0037372154,
0.013521683,
-0.0022071477,
-0.00017082576,
-0.0015491521,
-0.041368254,
0.005200903,
-0.014338162,
-0.011862174,
-0.0023282918,
-0.010335425,
0.007434603,
0.017152691,
0.031092571,
0.050873924,
0.010753621,
-0.0031680036,
0.018825475,
-0.017126137,
-0.0025921538,
0.01782977,
0.0034517797,
0.019276863,
0.025065232,
0.010713793,
-0.02307382,
-0.0029290342,
0.022343636,
0.010076541,
0.021493968,
0.022715366,
-0.0063658785,
0.017298726,
-0.0059875106,
0.0058281976,
0.0048158965,
0.019861009,
-0.0005227455,
0.006930112,
0.00084800937,
0.00030369023,
0.025290925,
-0.016834065,
-0.0051843077,
0.0051278844,
-0.018161671,
0.002016304,
-0.012227266,
-0.015094899,
0.009990247,
-0.017378384,
0.020073427,
-0.021308102,
-0.02737527,
0.03244673,
-0.010335425,
-0.005386768,
0.029579097,
-0.006209885,
-0.016024224,
0.004245025,
0.0056688846,
0.009771192,
0.015625942,
0.0030783901,
0.035792302,
0.014298334,
0.014444371,
0.011032419,
-0.0021938717,
-0.0076934863,
-0.020246016,
-0.007879351,
-0.008815315,
0.005088056,
0.0070230444,
0.028463908,
-0.013302628,
0.024507636,
-0.026552152,
-0.009173769,
-0.03690749,
-0.0175908,
0.021640005,
0.028755981,
-0.0020046874,
-0.02283485,
0.0057087126,
0.028145282,
0.016555266,
0.023790728,
-0.007905903,
-0.012691929,
-0.003816872,
-0.04022651,
0.009983609,
0.019449452,
0.012207352,
-0.0039595896,
0.020206187,
0.01800236,
-0.010461548,
-0.009060922,
-0.011118714,
-0.023392446,
0.012253818,
0.0077532283,
0.011112075,
0.019861009,
0.0014719849,
-0.009226873,
0.012625548,
-0.01468334,
-0.009943781,
0.044315543,
-0.018971512,
0.01844047,
-0.015758703,
0.02960565,
0.0014869205,
0.02114879,
0.0099039525,
-0.020617746,
-0.02473333,
0.017511144,
0.00012715992,
0.005705394,
-0.005937725,
-0.015625942,
0.010820002,
-0.02923392,
0.007268652,
-0.002195531,
0.011138628,
0.016117156,
-0.0039297184,
0.0018835433,
-0.6457483,
0.0012131014,
0.001089468,
0.0019266906,
0.000717323,
-0.015984396,
0.03499574,
-0.011351045,
-0.024534188,
0.012499426,
0.005801645,
0.002794614,
-0.0032941264,
-0.024401428,
-0.0021839144,
-0.004527142,
-0.008961352,
-0.01190864,
0.012247181,
-0.008224529,
-0.019157378,
0.030534975,
0.00091604923,
0.023418998,
0.004520504,
0.0051975837,
0.01248615,
-0.03812889,
-0.000066898974,
-0.0046698595,
0.009127302,
0.019276863,
-0.039403394,
0.025662655,
0.04564315,
-0.017882874,
0.00031447705,
-0.008363928,
0.0029190772,
0.032181207,
-0.032898117,
-0.0046067983,
0.038527172,
-0.0048590438,
0.0035911787,
0.006286222,
-0.0012413131,
0.0060538906,
0.002510838,
0.0053071114,
0.012705205,
-0.008211253,
-0.036960594,
-0.004474038,
-0.0028908656,
-0.014470923,
0.0049353815,
-0.044713825,
0.0046366695,
0.0049519762,
0.0002037048,
-0.012187438,
-0.016130432,
-0.014231954,
-0.03648266,
0.013607978,
-0.00012757479,
0.0253042,
0.00111685,
-0.012008211,
-0.0041122646,
0.026432667,
-0.03666852,
-0.016050776,
0.010959401,
0.01627647,
0.02418901,
-0.03961581,
-0.04394381,
-0.001823801,
0.005599185,
-0.014816101,
-0.02398987,
-0.003139792,
0.00801875,
-0.042271025,
0.005433234,
-0.005463105,
-0.0005405852,
-0.0018968193,
0.00764702,
-0.0018387366,
0.0026751293,
-0.029871171,
-0.014072641,
0.020471709,
-0.01931669,
0.004168688,
0.012101144,
-0.025755588,
-0.039881334,
-0.011205008,
0.03255294,
-0.02294106,
0.01024913,
0.012678653,
0.0010139603,
0.0021175342,
0.06117616,
-0.021560347,
-0.02023274,
-0.005124565,
-0.009764554,
-0.01559939,
0.01968842,
-0.032898117,
0.025131611,
-0.0004273237,
-0.015148003,
-0.02152052,
0.012386579,
0.02737527,
0.027853208,
-0.03419917,
0.009784468,
0.010176112,
0.0023067181,
-0.025118336,
-0.0029240558,
-0.012333475,
-0.012167524,
-0.007481069,
0.021878973,
-0.006262989,
0.01597112,
-0.010660689,
-0.0022884635,
-0.020631023,
-0.010693879,
-0.029446337,
-0.008436946,
-0.013780567,
0.0016122134,
-0.020790335,
0.00365424,
-0.036349896,
0.0063459645,
0.0032128105,
0.008981265,
0.010335425,
-0.004391062,
-0.022370188,
-0.0128180515,
-0.00055801007,
0.00031115804,
-0.015572838,
-0.02202501,
-0.042987935,
-0.0265256,
-0.01536042,
0.0130702965,
0.0012504404,
-0.0004916297,
0.0010280662,
0.0071889954,
-0.013548235,
-0.012798137,
-0.0051610745,
-0.0249723,
-0.024866091,
0.022171047,
-0.021374483,
0.00001233612,
0.036349896,
-0.0029058012,
0.007819609,
0.0011691245,
-0.020378776,
-0.01143734,
0.00047254533,
0.0071889954,
-0.015519733,
-0.0057850503,
0.0051411605,
0.036084376,
0.0020378777,
0.013515046,
-0.01255253,
0.015533009,
0.016289745,
0.018852029,
0.011331131,
-0.012572444,
-0.001664488,
0.007447879,
0.019343242,
-0.011915279,
0.027906312,
-0.014563856,
0.022954335,
0.028702877,
-0.0037239394,
0.006647995,
-0.000866264,
0.0018553316,
-0.014470923,
0.026167147,
-0.008609535,
0.013156591,
0.025569722,
0.0024627121,
0.006262989,
-0.018453745,
-0.022449845,
-0.0014139022,
0.016329573,
0.008861781,
0.0058116023,
-0.0094791185,
0.022423293,
0.0035944977,
-0.010295597,
0.0044640806,
-0.0062961793,
-0.015068347,
-0.0011616567,
0.0036907492,
0.018480297,
0.010049989,
-0.0035314362,
-0.004862363,
0.010308873,
-0.0015391951,
0.013130039,
0.01627647,
0.022821575,
0.004341277,
-0.012379941,
0.036217134,
-0.00052606454,
-0.01248615,
0.0058381543,
0.01289107,
0.030694287,
-0.010494738,
0.005931087,
0.032924667,
0.009432652,
-0.0024311815,
0.02984462,
-0.012333475,
0.0209762,
-0.015187831,
-0.022741918,
0.00068537745,
-0.013481855,
-0.002882568,
0.01684734,
0.02331279,
0.037066806,
0.011516996,
-0.010063265,
-0.0068969214,
-0.032632597,
-0.012433046,
-0.023392446,
-0.011975021,
-0.021998458,
0.008417033,
0.0026552153,
-0.017232347,
-0.014165573,
0.0034517797,
0.016196813,
-0.012433046,
0.013581426,
-0.002237019,
0.005283878,
0.015174555,
-0.008908247,
-0.028384252,
-0.0021938717,
0.014417819,
-0.0025888348,
-0.007288566,
-0.03698715,
0.0039131236,
-0.0028709515,
-0.005738584,
-0.0068438174,
0.012034763,
-0.0044707186,
-0.01763063,
0.003640964,
-0.007793057,
-0.01529404,
0.018307708,
-0.013833671,
-0.012220628,
-0.0056058234,
0.0022038287,
-0.0017209114,
-0.028941846,
-0.024135906,
0.014125745,
0.0067276517,
0.0053071114,
-0.024016421,
-0.012061316,
-0.018865304,
0.011078886,
-0.02337917,
0.0065351482,
0.018798923,
0.014909034,
-0.01119837,
-0.009273339,
0.011337769,
0.013966432,
-0.0058414736,
-0.03369468,
-0.014709893,
-0.0012935876,
-0.010269045,
0.06760178,
-0.008344014,
0.0077200383,
0.034119517,
0.02405625,
-0.0055228476,
-0.02073723,
-0.04107618,
0.029818067,
-0.013222972,
0.0050017615,
0.023936765,
-0.0061501423,
-0.0013682656,
0.0037770437,
0.013209696,
0.00030099353,
-0.02294106,
0.011722775,
0.023565035,
0.014776273,
-0.0018636292,
0.03082705,
0.049015272,
0.007773143,
0.004045884,
0.012784861,
0.006106995,
0.010335425,
-0.016316298,
0.006956664,
0.0046034795,
0.020684127,
0.041633774,
-0.0083241,
-0.008642726,
-0.008144872,
-0.015586114,
0.024255391,
0.0016097242,
0.023950042,
0.014457647,
-0.00219885,
0.008078492,
0.014696617,
-0.017736837,
-0.009797744,
0.0345178,
0.011590014,
-0.014656788,
0.02016636,
-0.01052129,
-0.0413417,
-0.007640382,
0.0033903779,
0.018121844,
-0.0188122,
0.007773143,
-0.011961744,
0.0008621152,
-0.019608764,
-0.029685305,
0.023551758,
0.0004347915,
-0.012174162,
-0.0013375647,
0.007155805,
-0.009459204,
-0.033137087,
-0.0003458003,
0.009213597,
-0.018679438,
-0.017670458,
0.014510751,
-0.00087622105,
0.015984396,
0.010156198,
-0.005111289,
0.010879745,
0.0026502367,
-0.0019200525,
0.0056556086,
-0.0087954,
-0.0431738,
0.008981265,
0.015015242,
-0.0042583016,
-0.033163637,
-0.033163637,
0.008045302,
-0.011888727,
0.007839523,
0.025835244,
0.0023664606,
-0.008762211,
0.0012811413,
-0.021029305,
0.0036210497,
0.002983798,
-0.030428767,
0.015918015,
-0.0044574426,
-0.0015947886,
-0.03738543,
0.0047528353,
-0.017073033,
-0.005635694,
0.0044375286,
-0.020471709,
-0.024905918,
0.0070695104,
-0.03860683,
0.013282714,
0.023870384,
0.01905117,
0.027534582,
0.016528714,
0.022542777,
0.0243616,
-0.0011077226,
-0.008596259,
0.0071956334,
0.01844047,
0.030880153,
-0.0012935876,
0.028092178,
0.0036741542,
-0.011649757,
-0.023963317,
0.003038562,
0.0048026205,
0.0579899,
0.011941831,
-0.03034911,
-0.02148069,
-0.010707156,
-0.0067674797,
0.0010305555,
-0.034119517,
0.003015329,
0.014723169,
0.0014014558,
-0.009392824,
-0.016488887,
0.04450141,
-0.03194224,
-0.00071690814,
0.028065626,
-0.003305743,
0.0035281172,
0.008025388,
0.007640382,
-0.02473333,
-0.0015607687,
-0.016090604,
-0.030747393,
-0.014205402,
-0.023087095,
0.02947289,
0.022051562,
0.008768848,
-0.016754407,
0.0047528353,
0.007839523,
0.022768471,
-0.0037007062,
0.025118336,
0.013076935,
-0.022277256,
0.02283485,
0.00984421,
-0.004912148,
-0.0069101974,
0.0028195067,
0.037810266,
0.008961352,
0.0018155035,
-0.026087489,
-0.025383858,
-0.016422506,
-0.011596653,
0.014059365,
-0.0066081667,
0.010581032,
-0.035340916,
-0.0037504914,
0.04269586,
-0.008689192,
0.022994164,
0.020989476,
0.0029589054,
0.01536042,
-0.008344014,
-0.009366272,
-0.004168688,
-0.01529404,
0.0073483083,
-0.026618533,
-0.015957844,
0.00032298203,
-0.0039662276,
-0.004666541,
0.0064090258,
-0.011895364,
-0.010966039,
-0.0099039525,
-0.01701993,
-0.011682947,
0.004029289,
-0.026193699,
-0.008144872,
-0.002703341,
-0.0034550987,
-0.023737624,
-0.017710285,
0.019449452,
0.011251475,
0.0063393265,
-0.026206974,
-0.031543955,
0.010169474,
-0.014563856,
-0.0007550768,
-0.012499426,
0.028755981,
0.038766142,
-0.0043180436,
-0.033376057,
-0.013402198,
-0.0023183348,
-0.0023282918,
0.030057035,
0.010156198,
-0.040120304,
-0.0014545601,
0.010587671,
0.00017839727,
-0.02029912,
-0.019383071,
0.03257949,
0.03183603,
-0.017099585,
-0.0063691977,
-0.00842367,
-0.014842653,
0.031889133,
0.0011185094,
0.0011359343,
0.00096417504,
-0.027720448,
-0.027242508,
0.04096997,
0.0005625737,
0.024335047,
-0.015373697,
-0.027720448,
-0.010368615,
-0.0031779606,
-0.006647995,
0.0169801,
-0.0009492394,
0.025078507,
-0.021613453,
0.0044541233,
0.011848898,
0.00004913704,
-0.023365894,
0.014431095,
0.004361191,
0.027454926,
0.0059443633,
-0.004009375,
0.011981659,
0.0055560376,
-0.00097330235,
-0.010288959,
-0.009976971,
-0.0425631,
-0.017856322,
-0.009857487,
0.023405721,
0.035978165,
-0.030163245,
-0.0034086325,
-0.008875057,
0.01623664,
-0.0020146444,
-0.01424523,
0.0064090258,
-0.009738002,
0.013422113,
0.0025622826,
-0.010103093,
0.034331933,
-0.0032891477,
-0.02171966,
-0.0012338454,
0.01671458,
-0.012711843,
0.0104881,
0.022529501,
-0.0037670867,
-0.008967989,
0.0037770437,
-0.031915687,
-0.018028911,
0.004902191,
-0.018267881,
-0.019568937,
-0.007972283,
-0.0075806393,
0.022356912,
-0.0028294637,
-0.01614371,
-0.0038932094,
-0.0023266324,
0.019754801,
-0.010016799,
-0.04083721,
0.03441159,
-0.0008438606,
-0.012685291,
0.03204845,
-0.013860224,
0.0026037705,
-0.015705599,
0.0042981296,
-0.00091107073,
-0.021467416,
0.0129906405,
-0.011550186,
0.029950827,
-0.011251475,
-0.0068504554,
0.0068570934,
-0.038049236,
0.0065882527,
-0.008184701,
0.0052871974,
0.0006899411,
-0.0042549823,
-0.041368254,
-0.003139792,
-0.005960958,
-0.010176112,
-0.0041056266,
-0.000097340606,
-0.018307708,
-0.03247328,
-0.011968383,
-0.02233036,
0.051537726,
0.011297941,
0.00470305,
-0.007441241,
0.000085827756,
-0.05416639,
-0.020896545,
-0.016422506,
0.008589622,
0.00182712,
0.038341306,
0.028171834,
0.016289745,
0.009738002,
0.016555266,
-0.02750803,
0.0032028533,
0.0015242595,
-0.0029788197,
0.0043246816,
-0.010335425,
-0.034570903,
0.012598996,
0.020856716,
-0.008735658,
0.02086999,
0.013900052,
0.0008044472,
-0.01455058,
-0.0051975837,
0.00984421,
0.029499441,
-0.019648593,
-0.01461696,
-0.012061316,
0.00646213,
0.015028518,
0.003478332,
-0.008164787,
-0.0023996509,
0.01292426,
-0.010196026,
0.008410394,
-0.019781353,
0.0032144699,
0.0013682656,
-0.02307382,
0.013913328,
0.02361814,
0.0016039159,
0.017232347,
0.0044972706,
0.006950026,
-0.0013914987,
0.018387366,
-0.0030949851,
-0.008802039,
0.013528322,
0.022078115,
0.013096849,
-0.013448665,
0.0038533811,
-0.0089348,
0.0048324917,
-0.011025781,
-0.009074198,
-0.02226398,
0.010687241,
0.007932455,
-0.025609551,
0.018320985,
0.01123156,
-0.016754407,
-0.010448272,
-0.01800236,
0.013740739,
-0.005360216,
0.00086709374,
0.0072487374,
-0.015373697,
0.015055071,
0.016303021,
0.006472087,
-0.0128446035,
0.02460057,
0.19669834,
-0.004543737,
0.0023598226,
0.039217528,
-0.0042815343,
0.020471709,
0.025821969,
-0.0061435043,
-0.00026469177,
0.027985968,
-0.014377991,
0.025078507,
-0.025012128,
0.0053403014,
0.0063891117,
-0.024852814,
-0.018599782,
-0.008596259,
-0.001001514,
0.029393233,
0.0025971325,
0.023299513,
-0.01147053,
0.0046101175,
0.018599782,
0.0057983263,
-0.0014728147,
0.022582605,
0.00801875,
-0.005934406,
-0.009976971,
-0.010315511,
0.0017773347,
0.010361978,
0.0053635347,
-0.007978922,
-0.014563856,
-0.017378384,
0.0033787615,
-0.0017242304,
0.010209302,
0.025768863,
-0.016953548,
-0.0053336634,
-0.0034318657,
0.014019537,
0.0011110416,
-0.011364321,
0.0002933183,
-0.012207352,
-0.037943024,
0.0029107798,
0.006983216,
0.0016371062,
-0.029818067,
-0.014829377,
0.018825475,
-0.024109354,
0.022197599,
0.031092571,
-0.009957057,
0.020471709,
0.0003420664,
0.0056390134,
-0.01721907,
0.02466695,
-0.030880153,
0.014231954,
0.009386186,
-0.0019615402,
0.009538861,
-0.0020494943,
-0.026100766,
0.022980887,
-0.011921916,
-0.021387758,
0.022250704,
0.03279191,
0.028437356,
-0.0012935876,
-0.017165966,
0.009359634,
-0.015015242,
-0.01008318,
-0.024507636,
-0.019940667,
0.031278435,
0.0033273166,
-0.005864707,
0.010813364,
0.004122222,
0.0012977364,
-0.019436175,
-0.034092963,
0.00097081304,
0.015771978,
0.005565995,
0.014709893,
-0.021732936,
-0.007315118,
-0.025715759,
0.07965646,
-0.0010537886,
0.015466629,
0.037677504,
-0.007812971,
-0.020883268,
0.028304594,
-0.0054597864,
-0.015506457,
0.032154657,
-0.02483954,
0.016449058,
0.00051693723,
0.021825869,
0.021241723,
0.013481855,
-0.025131611,
-0.008908247,
-0.0065550627,
-0.00097164285,
-0.030534975,
0.0034119515,
0.026512325,
-0.015572838,
-0.024919195,
-0.034119517,
-0.0047926633,
-0.02012653,
-0.015108175,
-0.0026402797,
-0.029074607,
-0.0056954366,
-0.014736445,
-0.01688717,
-0.0018769052,
0.0011035738,
-0.02090982,
-0.010614223,
-0.008742296,
0.0047196453,
0.014072641,
0.0030684331,
0.002821166,
-0.007122615,
0.0063990685,
0.015187831,
0.007600554,
-0.000252038,
-0.015055071,
-0.010494738,
-0.021732936,
-0.008682554,
-0.05302465,
0.026645085,
-0.0104881,
-0.0035978167,
-0.03467711,
0.013010555,
0.005088056,
-0.046333507,
0.022675538,
0.011497082,
-0.018785648,
-0.000008005837,
0.0035712644,
-0.16759719,
0.019781353,
0.003637645,
-0.0020826845,
0.024879366,
0.016807511,
0.018652886,
-0.013090211,
-0.029764963,
-0.018174948,
0.015413525,
0.017378384,
-0.046572477,
-0.050953582,
0.0042848536,
0.010481462,
-0.036588866,
0.022901231,
0.013727463,
0.024401428,
0.02195863,
-0.023644691,
0.010620861,
-0.010614223,
0.0015715555,
0.019900838,
-0.00024851155,
0.03223431,
-0.016741132,
-0.024162458,
-0.021454139,
0.005735265,
0.011682947,
-0.00043354687,
0.001525919,
0.010023437,
-0.014351439,
-0.006216523,
-0.008589622,
0.019090997,
0.022410017,
0.019648593,
-0.02361814,
0.01573215,
-0.011676309,
0.03624369,
0.007142529,
-0.014829377,
-0.0021042582,
0.0032410221,
0.025755588,
0.005748541,
0.013282714,
0.01123156,
0.01529404,
0.010003523,
0.008948076,
-0.020896545,
0.022795023,
-0.008656002,
-0.026339736,
-0.017896151,
-0.008251081,
-0.0046565835,
0.0005795837,
-0.029738411,
-0.013309266,
0.0037372154,
0.00092849554,
0.0054597864,
-0.020657575,
-0.0011160201,
0.03443814,
0.0051444797,
0.024693502,
0.011238199,
0.016077328,
0.000017360026,
-0.003025286,
0.0044408473,
0.0027182766,
0.026552152,
-0.0033439116,
0.001491899,
0.01468334,
0.0027680618,
0.017179243,
-0.0031763013,
0.027561134,
-0.006097038,
0.0029788197,
-0.011623205,
0.011145266,
-0.006923474,
0.021905525,
0.015957844,
0.005283878,
-0.0030933258,
0.0010305555,
0.000103511906,
0.01424523,
-0.006037296,
-0.025928177,
0.0027232552,
0.016873892,
-0.0015068346,
0.0096118795,
0.009684898,
0.021002753,
0.003637645,
-0.020989476,
-0.0014114128,
0.017750114,
0.014192126,
0.00416205,
0.014497475,
0.000070788454,
-0.023790728,
-0.009087474,
-0.023511931,
0.052254636,
-0.012300285,
-0.014019537,
-0.011138628,
-0.018918408,
-0.024680225,
-0.13222972,
0.000033579137,
-0.0007189825,
-0.0025290926,
0.002856016,
0.005443191,
-0.0070894244,
0.029658753,
-0.018095292,
0.023060543,
-0.03860683,
-0.0126454625,
-0.015612666,
0.0097446395,
0.027985968,
-0.002354844,
0.0096517075,
-0.02023274,
-0.0094392905,
0.030428767,
0.010780173,
-0.009392824,
-0.008748935,
-0.027242508,
0.014497475,
0.0019217121,
-0.0051511177,
0.009187045,
-0.008908247,
0.011490444,
0.020684127,
-0.009538861,
0.020989476,
-0.02825149,
0.005131203,
-0.010879745,
-0.021016028,
0.0129906405,
-0.015055071,
-0.022144495,
-0.0009550477,
-0.00039102192,
0.00076254463,
-0.022476397,
0.012638824,
-0.024175735,
-0.010129646,
-0.0042284303,
0.0030169883,
-0.0039230804,
-0.022768471,
-0.03133154,
-0.0169801,
-0.0063691977,
0.010547843,
-0.009339719,
-0.006797351,
0.0249723,
-0.00010164496,
-0.008065216,
-0.019144101,
-0.0013018852,
-0.002849378,
0.018891856,
0.01769701,
-0.011955107,
-0.023604862,
-0.024905918,
-0.0024262029,
-0.026273355,
-0.016050776,
0.005297154,
-0.014258506,
-0.00008219758,
-0.027773552,
0.010879745,
-0.013083573,
-0.015546286,
0.0029522674,
-0.024773158,
-0.017205795,
-0.020843439,
0.017139414,
0.0023565036,
0.015546286,
-0.0020212827,
0.0053768107,
-0.0011143606,
-0.006077124,
0.0072221854,
0.0056556086,
0.034305383,
0.01241977,
-0.040306166,
0.008954713,
0.03149085,
0.005974234,
-0.028039074,
0.018015636,
0.039323736,
-0.019489279,
-0.01905117,
-0.03021635,
0.014736445,
0.0014719849,
-0.014139021,
-0.00025701654,
0.0004509717,
0.012300285,
-0.0040790746,
0.005058185,
0.019396348,
-0.022277256,
0.021666557,
-0.025609551,
-0.008151511,
-0.027401822,
-0.034092963,
0.004019332,
0.0044142953,
0.019608764,
0.033615023,
-0.020803612,
-0.0034185897,
0.024852814,
0.020445157,
0.01522766,
0.025158165,
-0.0035148412,
0.024627121,
-0.00595432,
-0.0072553754,
0.015639218,
-0.012851242,
0.0036210497,
-0.005456467,
-0.0024311815,
0.001654531,
0.011224923,
0.007812971,
0.03130499,
0.018838752,
-0.02175949,
0.025662655,
0.015055071,
-0.017205795,
0.0011890386,
0.010766897,
-0.024321772,
0.02040533,
-0.007434603,
-0.0044408473,
0.034252275,
0.0031132398,
-0.009432652,
-0.012439683,
0.013143315,
0.0001656398,
0.0029273748,
-0.0075939153,
-0.012399855,
-0.018679438,
0.010361978,
0.037093356,
0.0026817673,
-0.0063227313,
0.00040097898,
-0.01282469,
-0.02114879,
0.013561511,
0.0005115438,
-0.034331933,
-0.032898117,
-0.0026635127,
-0.0039861416,
0.011218284,
0.0018586507,
0.00093596336,
0.0035911787,
0.0033339546,
0.019529108,
0.038659934,
0.020524813,
-0.01850685,
-0.019967219,
0.00028294636,
-0.0022751875,
0.0030468595,
0.012811413,
-0.0032708934,
-0.02086999,
0.013428751,
0.0058680256,
0.01011637,
-0.011497082,
-0.008742296,
-0.009631793,
0.021573624,
0.023432273,
0.013428751,
0.008304185,
0.03616403,
-0.0012612272,
0.00012394461,
0.014377991,
-0.020020323,
-0.018520126,
0.028543564,
-0.030880153,
-0.029579097,
0.004693093,
0.02689733,
0.0009011137,
0.012366665,
0.013700911,
-0.006113633,
-0.00693675,
0.028145282,
0.014165573,
-0.019781353,
-0.030880153,
-0.0038965284,
-0.004294811,
0.018082015,
0.0129508125,
-0.0160375,
0.018055463,
0.0053237067,
0.016873892,
-0.012539254,
0.004245025,
-0.008563069,
-0.015798531,
0.009120665,
-0.03616403,
-0.02320658,
-0.011556825,
-0.03515505,
0.029711857,
-0.0019831138,
0.01573215,
0.070628725,
0.022901231,
0.0024627121,
0.003826829,
-0.021122238,
0.014590408,
0.0067409277,
0.01931669,
0.009512309,
-0.02984462,
0.020962924,
-0.013820395,
0.016024224,
-0.038580276,
-0.036456104,
0.02324641,
-0.01590474,
0.028941846,
-0.005436553,
0.002172298,
0.034570903,
-0.0001485261,
0.010169474,
0.02554317,
-0.028888742,
-0.027534582,
0.014178849,
0.008450222,
0.014855929,
-0.0018470341,
-0.023020716,
0.013860224,
-0.018520126,
-0.021533795,
0.023365894,
-0.011556825,
0.0037637677,
-0.0020312397,
-0.0019947304,
0.014603684,
0.009764554,
0.0013732441,
-0.016674751,
-0.02628663,
-0.030694287,
-0.020060152,
0.0020959605,
-0.0063924305,
-0.033243295
] |
Angiogenesis is a significant prognostic factor in breast cancer, but the factors that control angiogenesis in vivo are not well defined. Multiple angiogenic polypeptides are known, and we have determined the expression of seven of these in primary human breast cancers; the relationship of expression to estrogen receptor and vascular density was also examined. Vascular endothelial growth factor (VEGF) and its four isoforms (121, 165, 189, and 206 amino acids), transforming growth factor (TGF)-beta1, pleiotrophin, acidic and basic fibroblast growth factor (FGF), placental growth factor | [
-0.03387879,
-0.03293345,
-0.010009062,
-0.018663993,
-0.005371806,
-0.008444147,
-0.025217468,
0.023978312,
-0.039550804,
-0.026546048,
0.0068281344,
-0.0058732172,
-0.00644489,
0.012576797,
-0.028845513,
0.008361111,
0.042386808,
0.0065918,
-0.012851455,
0.009606655,
-0.019992573,
0.036561497,
-0.0028631536,
-0.0054133246,
-0.0080034165,
0.013669043,
0.021589423,
-0.05094593,
0.016287878,
-0.026878193,
0.009070112,
0.0053398693,
-0.010769162,
0.015112597,
0.0024479723,
0.026699346,
0.0048767827,
-0.008795454,
0.015789662,
0.014844325,
0.020644087,
0.011554813,
-0.0018715092,
-0.0056241085,
-0.020644087,
-0.009044563,
0.017744206,
-0.021832146,
-0.021244504,
0.028973263,
0.014346108,
-0.006390597,
-0.014358883,
-0.018408496,
-0.022036541,
-0.001505032,
-0.0013134098,
0.030455139,
0.023314022,
-0.015534165,
-0.005997772,
-0.005997772,
-0.021921568,
0.005224896,
-0.00676426,
0.020286392,
-0.0031042781,
0.024693701,
0.005474005,
-0.003736631,
0.033444446,
0.028666666,
-0.015112597,
0.0075243614,
0.001884284,
-0.027261438,
-0.010852198,
-0.00047067177,
-0.024693701,
0.012295752,
0.006745098,
-0.009996287,
0.00531432,
0.009415032,
0.0042124926,
0.008073678,
-0.019788176,
0.003822861,
0.008993464,
0.0012583184,
0.03180927,
0.002291481,
0.0039569964,
0.005825312,
-0.003845217,
-0.02017142,
-0.0077543077,
0.012960042,
0.029382056,
-0.01679887,
0.001204824,
0.010775549,
0.0069111707,
-0.009798277,
-0.023020202,
0.00075171754,
0.004056001,
0.006135101,
0.039908495,
0.005403743,
-0.02081016,
0.05477837,
-0.0019242052,
-0.025715686,
0.027951278,
-0.0056496584,
0.030838383,
0.018012477,
-0.009836601,
0.018893939,
0.013732918,
0.015419192,
0.018676767,
-0.012781194,
0.022521984,
-0.0012639074,
0.017693108,
0.015227569,
-0.021985443,
0.004515894,
0.022636957,
0.008303625,
0.006282011,
0.0029094622,
-0.04179917,
-0.009453357,
-0.03633155,
-0.013349673,
-0.030940583,
-0.036765896,
-0.0113951275,
0.011669786,
-0.016632799,
0.003931447,
-0.023390671,
0.0024016637,
0.033316698,
0.020682413,
0.03106833,
-0.0030451945,
-0.0021988635,
0.0006978238,
0.00942142,
-0.008546346,
-0.009670529,
-0.014972074,
-0.00047905525,
0.02779798,
-0.022253713,
-0.00062716316,
0.018063577,
0.010609477,
0.023365121,
0.00485762,
0.025792334,
0.011695336,
0.00052736,
-0.0034172607,
-0.0038388295,
-0.012391563,
-0.018996138,
0.02902436,
-0.034185383,
0.018715091,
-0.00956833,
0.0070516933,
-0.0013573233,
0.011625074,
-0.032856803,
-0.017999703,
0.00037286468,
0.010839423,
0.014869875,
-0.008833779,
-0.011350416,
0.004988562,
0.022496434,
-0.03106833,
0.00678981,
-0.038043376,
-0.008648545,
0.019788176,
0.016683897,
-0.016249554,
-0.65325254,
-0.03704694,
0.0132347,
-0.010488116,
0.030710636,
0.011618687,
0.018855615,
-0.012244652,
-0.022854129,
0.016032383,
-0.011254605,
0.020043671,
-0.017284313,
-0.015189245,
-0.0006786616,
-0.031911466,
-0.011669786,
-0.034951873,
0.018663993,
0.0062021688,
-0.020196969,
0.0061542634,
0.0006726734,
0.026724895,
0.0041645872,
0.022713607,
0.03165597,
-0.030608438,
0.016862744,
0.04368984,
-0.009881313,
0.020605763,
-0.009236185,
0.00091260026,
0.039780747,
-0.0022020573,
0.0046659983,
0.0065534757,
0.00895514,
0.038733214,
-0.00595306,
0.0060871956,
0.03592276,
-0.007645722,
-0.036076054,
0.04445633,
0.01687552,
0.0032048796,
-0.002377711,
0.0072305407,
-0.0000011851628,
0.010833036,
-0.024106061,
-0.026827095,
0.016543375,
0.00514186,
0.028181223,
-0.030710636,
-0.003972965,
-0.011146019,
0.018216874,
0.015368093,
-0.01251931,
-0.01886839,
0.01028372,
0.02902436,
-0.014295009,
0.015214795,
-0.008648545,
0.007901218,
0.027414735,
0.036306,
0.0075690732,
-0.024706475,
0.029535353,
0.029356506,
0.011701723,
0.025690136,
0.013886215,
-0.000098106524,
0.006489602,
0.0000330598,
-0.03441533,
0.034185383,
0.0011856618,
0.0029094622,
-0.027951278,
0.012717321,
-0.0005149844,
0.008744355,
0.026929293,
-0.012640671,
-0.016722223,
-0.039780747,
-0.023135176,
0.024846999,
0.016926618,
0.015163695,
0.014295009,
-0.03658705,
-0.020324718,
-0.0120721925,
0.0076712715,
0.0066684494,
0.00858467,
0.011631462,
-0.02612448,
0.02125728,
0.00924896,
-0.02779798,
0.005965835,
0.0042348485,
0.0021781046,
-0.007217766,
-0.008718805,
-0.01753981,
-0.005244058,
0.012116904,
-0.009038175,
-0.01025817,
0.008795454,
0.011286542,
-0.009006239,
0.0049981433,
0.055238266,
0.004103907,
-0.028641118,
-0.014295009,
-0.010098484,
-0.01106937,
0.005493167,
-0.005758244,
0.008776292,
-0.0198265,
0.012474599,
0.004924688,
0.011484551,
0.005994578,
0.0021461674,
-0.022994652,
0.0041390373,
-0.0013677027,
0.02176827,
-0.013349673,
-0.0064832144,
-0.013036691,
-0.026929293,
0.0064193406,
0.009670529,
0.012206328,
0.005087567,
-0.021142306,
0.000029541741,
0.016453952,
0.021308377,
0.0007605002,
0.008629382,
-0.009453357,
0.009530006,
0.0069111707,
-0.0005433285,
0.0030244356,
-0.014358883,
-0.012206328,
-0.0019737077,
-0.014576054,
-0.022828579,
0.003982546,
-0.00797148,
-0.035437316,
-0.008310012,
-0.009900475,
-0.004860814,
0.013630719,
-0.008188651,
0.005643271,
-0.022841355,
-0.014972074,
-0.004752228,
-0.01552139,
0.0006874443,
-0.039346404,
-0.013400773,
0.019200535,
0.05564706,
0.030787284,
0.03099168,
0.011503713,
0.003845217,
0.0038388295,
-0.017360963,
0.008226976,
-0.0011944445,
0.01594296,
-0.008552733,
-0.047317885,
0.0069622695,
0.007958705,
-0.0051226974,
0.014026738,
0.047879975,
-0.0072113783,
0.017028818,
0.01421836,
0.010111259,
-0.008367498,
-0.015585264,
0.006147876,
0.013145276,
0.0134390965,
0.010756387,
0.024221033,
-0.012340464,
0.009664142,
0.0011976381,
-0.012378788,
0.0046947417,
-0.0014124146,
-0.0021749109,
-0.009785502,
-0.015457517,
-0.007077243,
0.004100713,
-0.01849792,
-0.023607843,
0.006904783,
0.011580362,
-0.0021286022,
0.0113887405,
-0.027542483,
-0.013732918,
0.025000297,
0.014691028,
0.01621123,
-0.000030539773,
-0.0006878435,
0.0039697713,
-0.012480986,
0.021717172,
0.014984848,
0.003340612,
0.0057869875,
0.029586453,
0.021014556,
0.008884878,
-0.001884284,
0.019890374,
0.008923203,
-0.010053773,
0.012308527,
0.021346701,
-0.00033653632,
0.012391563,
0.012097742,
-0.011752822,
-0.0107308375,
0.0048480392,
0.009817439,
0.026980393,
0.017079916,
0.028155673,
0.0042124926,
-0.018919488,
0.0033693553,
0.005988191,
0.03037849,
0.016939394,
-0.00678981,
-0.016249554,
-0.0025453803,
-0.0044136955,
-0.014780452,
0.015572489,
-0.02511527,
0.0055474597,
-0.00031517845,
0.0005748663,
0.00612552,
-0.0036567885,
0.01075,
0.005071598,
-0.021525549,
0.01684997,
0.049387403,
0.0034587788,
0.0050332737,
0.0008806632,
-0.0028216355,
0.006508764,
0.0120721925,
0.024157159,
-0.003318256,
0.0006407364,
-0.011126856,
-0.008693256,
-0.009549168,
-0.0086677065,
0.000009344072,
0.0003451194,
-0.0019960636,
0.010066547,
-0.010979947,
0.009613042,
-0.0002918245,
0.047036838,
0.016390078,
-0.007760695,
-0.0014435531,
-0.0148571,
-0.011631462,
-0.019226084,
-0.007818182,
0.005291964,
-0.014754902,
0.0036024954,
0.017131016,
0.019737076,
-0.012845068,
0.017756982,
0.004308304,
0.008904041,
-0.01352852,
0.0131836,
-0.0021270053,
0.01807635,
0.006192588,
0.014065063,
0.022624183,
0.0054133246,
0.0020359848,
-0.03183482,
-0.0047490345,
0.014665478,
-0.00022355912,
0.0018954619,
-0.00026308117,
0.012391563,
-0.012953654,
0.0090765,
0.01743761,
-0.012449049,
-0.04573381,
-0.0066301245,
-0.011471776,
0.0008854538,
-0.003318256,
0.029484253,
0.015227569,
0.019468805,
0.006192588,
0.00546123,
0.016377302,
-0.0018188132,
-0.013962864,
-0.025153594,
0.022036541,
-0.007882056,
-0.0049694,
-0.0048512327,
-0.031502675,
0.0078117945,
0.003810086,
0.00471071,
0.009836601,
0.011248217,
0.028181223,
0.002505459,
-0.0004207702,
-0.010500891,
-0.015329768,
0.010794711,
-0.003490716,
0.024336006,
-0.030506238,
-0.006777035,
-0.014052288,
-0.005771019,
-0.04090493,
0.000996435,
-0.025179144,
0.017744206,
-0.0056177215,
-0.013822341,
-0.01690107,
-0.013336899,
-0.017475937,
0.009779114,
-0.014358883,
0.022279263,
-0.008527184,
-0.0020487597,
-0.007939543,
-0.0080034165,
-0.023671716,
0.0029813205,
-0.01926441,
-0.013707368,
-0.006649287,
0.012116904,
0.024744801,
0.0052153147,
-0.010520053,
0.0029813205,
0.010979947,
-0.007517974,
-0.008993464,
-0.002633207,
-0.02910101,
-0.018446822,
0.0010842617,
-0.020056447,
-0.022611408,
-0.003736631,
-0.00905095,
0.01483155,
0.00057566474,
0.013158051,
-0.024284909,
0.0055921716,
0.007926768,
0.008642157,
-0.003695113,
0.0054771984,
-0.013605169,
0.0046723858,
-0.025715686,
-0.014052288,
-0.019277183,
-0.006853684,
0.020733511,
-0.012021094,
-0.023978312,
-0.010762774,
-0.0035450088,
0.0056688203,
-0.016862744,
0.0053366753,
0.0044488264,
0.016620023,
0.016402852,
-0.008533571,
0.002816845,
0.01190612,
0.000495423,
0.0007940341,
0.0069558825,
0.035616163,
-0.015700238,
-0.02280303,
0.0068983957,
0.011618687,
0.0066301245,
-0.020886809,
0.0022866905,
-0.0018315879,
0.03898871,
-0.005266414,
-0.013413548,
-0.016466726,
-0.023773916,
-0.02777243,
-0.005074792,
0.0017230021,
-0.019941473,
-0.022624183,
0.008495246,
0.018382948,
-0.036612596,
0.025881758,
-0.03308675,
-0.0075307484,
0.0050236927,
-0.0020423722,
0.000685049,
-0.0044711824,
0.015419192,
0.00079642935,
-0.0020503565,
-0.040777184,
-0.031144978,
-0.015010398,
-0.0263672,
0.039244205,
0.03487522,
0.039499704,
0.007997029,
-0.0018124257,
0.049234107,
0.009830214,
0.023352347,
-0.01520202,
0.030608438,
-0.032780156,
0.034773026,
0.00043474266,
0.003941028,
0.030710636,
-0.015687462,
0.022764705,
0.0072497027,
-0.021985443,
-0.026022281,
-0.0003704694,
-0.035616163,
-0.04167142,
0.015342543,
-0.01621123,
0.017871955,
-0.044890672,
-0.001788473,
0.009325609,
-0.0005752655,
-0.0013102161,
-0.007850119,
0.020771835,
-0.0030691472,
0.002599673,
0.002043969,
-0.009089275,
-0.01650505,
-0.020311942,
0.0051354724,
-0.020350268,
0.03482412,
0.0011601121,
0.020401366,
0.015904635,
-0.020094771,
-0.008661319,
-0.0005221702,
-0.022445336,
-0.02046524,
-0.0043945336,
-0.013158051,
-0.002409648,
-0.020056447,
-0.015827985,
-0.0264183,
-0.0067003863,
-0.00074253563,
-0.026290553,
0.022598634,
0.004014483,
-0.016671123,
0.03658705,
-0.000685049,
0.011573975,
-0.015661914,
0.021717172,
0.023032976,
-0.010239008,
-0.010053773,
-0.004356209,
-0.014576054,
0.010973559,
0.023773916,
0.009044563,
0.021014556,
-0.023492869,
0.0034428104,
0.026239453,
-0.030557338,
-0.026571598,
0.037787877,
-0.0009110034,
0.00629798,
0.0066876113,
-0.018702317,
-0.03758348,
0.0019689172,
-0.001150531,
0.011229055,
-0.00028982843,
-0.02248366,
-0.0023282086,
-0.00008089047,
-0.014001188,
0.009606655,
-0.0029286244,
-0.014691028,
-0.020759061,
0.007792632,
0.012487373,
0.010762774,
-0.011797534,
0.023633393,
0.0033022875,
-0.0006970254,
0.012148841,
-0.0029078654,
0.0083419485,
0.0059243166,
0.006432115,
0.04090493,
-0.0032895128,
0.01350297,
0.021678846,
0.0020615344,
0.00710918,
-0.01350297,
-0.0093447715,
-0.0015936572,
-0.01753981,
-0.00693672,
0.021627748,
0.010903298,
-0.02413161,
0.013119726,
-0.024463754,
0.005448455,
-0.02452763,
-0.012500148,
0.012046643,
-0.041364826,
-0.014358883,
-0.009331997,
0.02899881,
0.0264694,
0.01847237,
-0.00609997,
-0.020669637,
0.027976828,
-0.02506417,
0.004627674,
0.016224004,
0.007153892,
-0.02700594,
-0.000030290264,
-0.023556743,
-0.00034152647,
0.0022818998,
-0.005898767,
-0.01751426,
0.0038292482,
-0.0006618947,
0.017475937,
0.009868538,
-0.03313785,
0.0020200163,
0.00025030636,
0.010890523,
-0.01616013,
-0.0025533645,
0.0064033717,
0.01124183,
0.015955733,
-0.0052376706,
-0.020196969,
-0.013336899,
-0.0042444295,
-0.008220588,
0.0022531566,
0.012027481,
0.0033246435,
-0.01219994,
0.017871955,
-0.013950089,
-0.0029110592,
-0.016517825,
-0.019622102,
-0.020976232,
0.029203208,
0.00079922384,
-0.022930779,
-0.011011884,
0.030531788,
-0.015713012,
0.015278669,
-0.026341652,
0.0011912507,
-0.010462567,
-0.04228461,
-0.010277332,
0.0001853345,
-0.022739155,
0.032703504,
0.016913844,
-0.009721628,
-0.023454545,
-0.013809566,
-0.04568271,
-0.022828579,
0.008239751,
0.017654782,
-0.009287285,
0.0134390965,
-0.0077543077,
0.0069431076,
0.006192588,
0.021666072,
-0.0008092042,
-0.008884878,
0.0016750966,
-0.011650624,
-0.0047011287,
0.0056911763,
-0.03564171,
-0.044584077,
0.02713369,
-0.0070389183,
-0.030710636,
0.007588235,
-0.022636957,
0.027849078,
-0.027619133,
0.01387344,
0.008693256,
0.01852347,
0.024093285,
-0.03175817,
-0.015368093,
0.0075946227,
0.013937314,
-0.003136215,
0.00996435,
-0.012685383,
0.010328432,
-0.0008878491,
-0.011810309,
-0.012991979,
0.012480986,
-0.00044512216,
0.014052288,
0.035411764,
-0.004614899,
0.034287583,
0.023454545,
0.03155377,
-0.005161022,
-0.014090612,
-0.006371435,
0.01589186,
0.0075946227,
0.008872103,
-0.025971182,
-0.0151509205,
-0.00260127,
-0.024336006,
0.0025166369,
0.021666072,
-0.029433155,
-0.014678253,
0.017820856,
-0.0056049465,
0.000068914094,
-0.00045430407,
0.0015681075,
-0.013605169,
-0.028947713,
-0.023991087,
-0.021065656,
-0.0042987224,
-0.025639037,
-0.001809232,
-0.0025022654,
0.015751338,
0.009600268,
-0.023262924,
-0.022598634,
0.0008012199,
0.172511,
-0.0148571,
-0.023658942,
0.015240344,
0.022815805,
-0.0034939097,
0.01854902,
-0.0042572045,
0.011120469,
0.00297653,
0.0047937464,
-0.0063426914,
-0.033853237,
-0.00511631,
0.0144483065,
-0.010781937,
-0.034798574,
0.0035354279,
0.010175134,
0.0075818477,
-0.0042572045,
-0.01783363,
0.02187047,
0.000008439606,
0.026622698,
-0.010960784,
-0.0035450088,
0.022330362,
0.015955733,
-0.0013685012,
-0.0078117945,
-0.004627674,
-0.0023457739,
0.019072786,
-0.0137840165,
-0.0016096256,
-0.010181521,
-0.0075690732,
-0.0009237782,
-0.0043625967,
-0.0020104353,
0.026929293,
-0.023582293,
-0.003254382,
0.0010187909,
0.009280897,
-0.020043671,
-0.003158571,
-0.013464646,
0.011644237,
-0.043051098,
0.012940879,
0.009478907,
0.021487225,
-0.009319222,
0.009331997,
0.023058526,
0.00870603,
-0.0037781491,
0.009632205,
0.009523618,
0.003672757,
-0.03449198,
0.013975639,
-0.015559714,
0.022828579,
-0.02413161,
-0.003982546,
-0.000746927,
0.003963384,
-0.01089691,
0.0070580808,
-0.019021688,
0.018370172,
-0.012187166,
-0.033240046,
0.019775402,
0.0030978906,
0.006713161,
0.026878193,
-0.0029909017,
0.012698158,
-0.023927214,
-0.017756982,
-0.025294118,
-0.02147445,
0.010021836,
0.018702317,
-0.005493167,
-0.003200089,
0.011471776,
-0.02179382,
-0.012615122,
0.0072624777,
0.021640522,
0.002923834,
-0.02450208,
0.017092692,
-0.0067387107,
-0.0052600265,
-0.02715924,
0.060399286,
0.019749852,
0.014639929,
-0.0031441993,
0.000872679,
-0.018114677,
0.0182041,
-0.013196375,
0.016275104,
-0.016057933,
-0.010647802,
0.0023633393,
-0.020414142,
-0.014013963,
0.018025253,
0.021308377,
-0.018970588,
0.023467321,
-0.0198265,
-0.022355912,
-0.036740344,
0.0075115864,
0.03441533,
-0.012155228,
0.021729946,
-0.030020796,
-0.007690434,
-0.0061542634,
-0.029203208,
-0.006285205,
-0.006457665,
-0.014742127,
0.0024112447,
0.02051634,
-0.0033150623,
-0.005311126,
0.01674777,
-0.012206328,
0.027644683,
-0.00961943,
-0.0058891857,
-0.008035353,
-0.0005708742,
-0.0007589034,
0.004308304,
0.00870603,
0.0023457739,
-0.011752822,
-0.01660725,
-0.026878193,
0.000008801393,
-0.00039621862,
0.0035034907,
0.026775995,
-0.023991087,
-0.0039346404,
-0.044814024,
0.011120469,
0.006029709,
-0.02511527,
-0.012065805,
0.03308675,
-0.03377659,
0.0012503342,
-0.009325609,
-0.1583054,
0.011644237,
0.02774688,
-0.031988118,
0.017143792,
0.009683304,
-0.0032511884,
-0.016952168,
-0.015380868,
0.008099227,
0.03658705,
-0.0012447452,
-0.033853237,
-0.011114082,
0.00939587,
-0.015265894,
0.0033342247,
0.044532977,
0.018536245,
0.021614973,
0.0065055704,
-0.017565358,
0.0039889333,
-0.010737225,
-0.0055602347,
-0.018983362,
0.017718658,
-0.0050332737,
0.000942142,
0.010162359,
-0.0063203354,
0.0075754602,
0.029995246,
-0.0016136178,
0.009146762,
0.000942142,
0.011516488,
0.010679739,
-0.00471071,
0.009587493,
0.03104278,
0.019788176,
0.009753565,
0.0025342023,
-0.008680481,
0.012621509,
0.0116123,
-0.014908199,
0.027389186,
0.012027481,
0.036816992,
0.0024783125,
-0.0036855317,
0.008195039,
-0.009325609,
0.009376708,
0.016045157,
0.02112953,
0.0031937016,
-0.012627897,
-0.008252525,
-0.0072241533,
0.020503566,
0.013669043,
-0.011676174,
-0.023850564,
-0.02910101,
0.020503566,
-0.03559061,
-0.0051258914,
-0.023020202,
-0.022381462,
0.020107547,
-0.024885323,
0.019571004,
0.006981432,
-0.0144483065,
0.022585858,
-0.00013563252,
0.011554813,
-0.0058221184,
0.014806001,
-0.012180778,
-0.013400773,
0.0041422313,
0.021372251,
0.01483155,
0.007907606,
-0.016262328,
-0.022113191,
0.02705704,
-0.038631015,
0.019979797,
0.0010890523,
0.014128936,
0.016249554,
0.009446969,
-0.019111112,
-0.008833779,
0.014780452,
0.03354664,
-0.01190612,
-0.025370765,
0.025345217,
0.02973975,
0.012155228,
-0.00035330324,
0.010647802,
0.05534046,
-0.0076393345,
-0.015444742,
-0.0049853683,
0.0022723188,
0.0023521613,
-0.019417707,
0.04287225,
0.0023170307,
0.01259596,
0.012698158,
-0.020094771,
0.057844326,
0.03392989,
0.024578728,
0.019404931,
0.0025853016,
-0.023390671,
-0.13531075,
-0.009919638,
0.009561943,
0.020286392,
-0.011011884,
0.013170826,
-0.00895514,
0.016543375,
-0.027542483,
0.024719251,
-0.011752822,
0.0058732172,
0.004215686,
-0.0039346404,
0.033316698,
-0.012040256,
-0.000094663315,
0.0107180625,
-0.018012477,
0.030071896,
-0.0014706997,
0.021934344,
-0.011714498,
-0.002856766,
-0.0029222372,
-0.00811839,
-0.019583778,
0.0043594027,
-0.0015728981,
0.00479694,
-0.0043114973,
-0.013937314,
0.026954843,
-0.0074093877,
-0.03564171,
-0.029305406,
0.0090765,
-0.02248366,
0.013260249,
-0.005678402,
-0.012391563,
-0.0026156418,
0.016083483,
-0.0012774806,
-0.017207665,
-0.014920974,
-0.03763458,
-0.0033629679,
0.012282977,
-0.023952764,
-0.02777243,
-0.02846227,
-0.014065063,
0.00060959783,
0.007486037,
-0.0075818477,
0.014576054,
0.0061287135,
-0.008131164,
0.004819296,
-0.03308675,
0.020963458,
-0.026022281,
0.0093703205,
0.012851455,
-0.011995544,
-0.00032116662,
-0.030071896,
0.012302139,
-0.022330362,
-0.0014515375,
-0.0064704395,
-0.014346108,
-0.023850564,
-0.032703504,
-0.008233363,
-0.0148571,
-0.012212715,
0.025306892,
-0.031272728,
-0.018370172,
-0.020337492,
0.029484253,
-0.005256833,
0.015623589,
0.019749852,
0.012825906,
-0.022151515,
0.0069878194,
-0.03349554,
0.008782679,
0.04900416,
0.01416726,
-0.019008912,
-0.019251633,
-0.000043938348,
0.0026875,
-0.020554664,
0.015585264,
0.025613487,
-0.0062085562,
0.001011605,
-0.047803327,
0.017501485,
0.0050779856,
-0.0017597296,
0.010903298,
-0.0058891857,
0.0035513963,
-0.0068920082,
0.0076840464,
0.012097742,
0.0025038621,
0.020350268,
-0.00873158,
0.0018523469,
-0.012985591,
-0.022419786,
0.038784314,
0.0113887405,
0.0052632205,
0.023684492,
-0.01355407,
0.0066237375,
0.0027114528,
0.0061542634,
-0.029918598,
0.00061758206,
-0.0075307484,
0.004528669,
-0.014984848,
0.000050450508,
0.005838087,
-0.040215094,
-0.016594473,
-0.013720143,
-0.013630719,
-0.022751931,
-0.008469697,
0.027849078,
0.019392157,
0.02777243,
-0.014959299,
-0.02973975,
0.017756982,
-0.0026028669,
0.012110516,
-0.0056911763,
-0.024361556,
-0.014333333,
-0.003394905,
0.0054676174,
0.0005481191,
-0.0002698678,
0.0018395722,
-0.024489304,
0.00062436867,
-0.0062660426,
0.0029398024,
-0.01251931,
-0.0032416072,
-0.013617944,
0.016249554,
0.013247475,
-0.0090190135,
0.0014100194,
-0.0008535168,
-0.013451871,
-0.017693108,
0.0071155676,
0.01716934,
-0.027184788,
-0.0165817,
-0.020158645,
-0.012512923,
0.006304367,
0.004959819,
-0.010967172,
-0.0124234995,
0.0154830655,
-0.0017006461,
0.027465835,
0.015968509,
0.01421836,
-0.0048863636,
0.022675281,
0.029560903,
0.002526218,
-0.004688354,
0.022879679,
0.025013072,
-0.009223411,
-0.012487373,
0.004902332,
0.014678253,
-0.0040847445,
0.019634878,
-0.0005840482,
-0.011682561,
0.022419786,
-0.0083419485,
0.037966724,
-0.0071475045,
-0.0019721107,
-0.00088146166,
-0.0060392898,
-0.024846999,
0.014920974,
-0.021640522,
-0.025651813,
-0.029279858,
-0.016811647,
0.0017325832,
0.011912507,
0.01517647,
-0.0086677065,
-0.0023936795,
0.026622698,
-0.00959388,
-0.003085116,
-0.016377302,
0.04701129,
0.0068345214,
0.01350297,
-0.0038835413,
0.0016176099,
0.0182041,
0.011682561,
0.020912359,
-0.015687462,
0.022279263,
-0.020324718,
-0.0068345214,
-0.015674688,
-0.019443257,
-0.0049534314,
0.012244652,
-0.017233215,
-0.0042444295,
0.029330956,
-0.008948752,
0.08533571,
0.0032176545,
-0.011682561,
0.02049079,
-0.01193167,
0.020056447,
0.010219845,
0.043306597,
-0.030659536,
-0.020631313,
0.010635027,
-0.009293672,
0.007856506,
-0.051329173,
-0.03099168,
0.017552584,
-0.014665478,
-0.0005157828,
-0.00023773118,
-0.007549911,
-0.0007445317,
-0.02838562,
0.0039921273,
0.032294713,
-0.05482947,
0.00742855,
0.038579915,
0.016977718,
0.00728164,
-0.03426203,
-0.026137255,
-0.00092856877,
-0.029305406,
-0.0005712734,
0.014205585,
-0.015585264,
-0.010935235,
-0.023607843,
0.011669786,
0.026597148,
0.016032383,
0.0061382945,
-0.020707961,
-0.021742722,
0.0052408646,
-0.01849792,
-0.03714914,
-0.011024659,
0.002537396
] |
Kinetochores attach the replicated chromosomes to the mitotic spindle and orchestrate their transmission to the daughter cells. Kinetochore–spindle binding and chromosome segregation are mediated by the multi-copy KNL1Spc105, MIS12Mtw1 and NDC80Ndc80 complexes that form the so-called KMN network. KMN–spindle attachment is regulated by the Aurora BIpl1 and MPS1Mps1 kinases. It is unclear whether other mechanisms exist that support KMN activity during the cell cycle. Using budding yeast, we show that kinetochore protein Cnn1 localizes to the | [
-0.025615688,
0.0029946875,
-0.0028305268,
-0.024129951,
-0.02873308,
0.019752335,
-0.012555799,
0.013583876,
-0.0011972117,
-0.014406337,
0.02292279,
0.010771589,
0.020296222,
0.0197656,
-0.02354627,
0.011540988,
0.0163431,
-0.011302209,
-0.0061850413,
-0.024965677,
-0.026066715,
0.024793226,
-0.0053062015,
-0.039398547,
0.011222616,
0.0066460175,
0.0056245737,
-0.028361646,
-0.008158285,
-0.0108843455,
-0.0031538736,
-0.01701964,
0.015825747,
-0.009066972,
-0.037514843,
-0.02000438,
0.01853191,
-0.02159624,
0.008503188,
-0.0025453186,
0.013099685,
-0.011912422,
-0.010260867,
0.0063840235,
-0.012476207,
0.027433062,
-0.006924593,
0.0077934833,
-0.010970572,
0.0011748262,
-0.013172645,
0.017417606,
-0.029051453,
0.009226158,
-0.007010819,
-0.034569904,
0.013995106,
0.006636068,
-0.015096143,
-0.013636938,
-0.022909526,
-0.011567519,
-0.0023397033,
0.01513594,
-0.0001618806,
-0.0036214825,
0.010148111,
-0.0063674417,
0.008105223,
-0.013902248,
0.042370018,
0.023347287,
-0.0071567395,
-0.011799665,
0.012257325,
-0.043245543,
-0.01501655,
-0.0008531377,
-0.019394167,
0.01846558,
0.017271686,
-0.0068847965,
0.013146115,
0.032341298,
0.008695538,
-0.008622577,
0.015984932,
0.010625669,
0.011560886,
0.011647113,
0.027048362,
0.034012754,
0.026690194,
0.005743963,
-0.023519738,
0.006317696,
-0.013524181,
0.024196278,
-0.03451684,
-0.0019914838,
-0.008403697,
0.014313479,
0.0018322977,
-0.016157383,
-0.020614592,
0.00021141897,
0.02186155,
-0.012443042,
0.025708547,
-0.0031522154,
-0.012237427,
0.022193188,
-0.0047556832,
-0.031306587,
0.007866444,
-0.0055615623,
0.008470024,
-0.0028553996,
-0.0018455632,
-0.004294707,
0.013928779,
0.04274145,
-0.007892975,
-0.024567712,
0.032527015,
0.022630949,
-0.005044208,
-0.0025735078,
-0.005153648,
-0.0035352567,
0.018903343,
0.0053658965,
0.0011051823,
0.023294225,
-0.018120678,
-0.005806974,
-0.0018853598,
-0.017722713,
-0.02646468,
-0.016051259,
0.008078692,
0.032235175,
-0.006642701,
0.004065877,
0.010446584,
0.014260417,
-0.010134845,
0.0053393655,
0.007402151,
0.0051470157,
0.0071169427,
-0.006791938,
0.014751241,
-0.0015926895,
0.004666141,
0.0319168,
0.011381802,
-0.00418195,
-0.005644472,
-0.025801405,
-0.01853191,
-0.0028902215,
0.005956211,
-0.02446159,
0.010546075,
0.03632095,
-0.02253809,
-0.018982936,
0.005239874,
-0.025483033,
0.001852196,
0.0013796124,
-0.0384169,
0.018133944,
-0.030935155,
0.011010368,
0.003783985,
0.014472664,
-0.03632095,
-0.013457853,
0.003996233,
0.008947582,
0.010028721,
0.009299118,
-0.022524826,
-0.0056743193,
0.0063740746,
0.0005807803,
0.013053256,
-0.01166701,
-0.002027964,
-0.017629854,
0.003032826,
-0.0078996075,
-0.61721736,
-0.010134845,
0.03849649,
-0.020017644,
-0.00365133,
0.025469767,
0.016820658,
0.011401701,
-0.012190998,
0.025721813,
-0.016104322,
0.015825747,
0.0014915401,
-0.017775776,
-0.044147596,
-0.03181068,
-0.009458304,
-0.01250937,
0.033004574,
-0.005180179,
-0.021609506,
-0.011773135,
0.0021357462,
0.021383991,
-0.011143023,
-0.022007471,
0.039557733,
-0.010479748,
-0.006168459,
0.025774874,
-0.034304593,
0.024448324,
-0.01696658,
0.007501642,
0.045261897,
0.006141928,
-0.0209197,
0.0032881869,
0.021543179,
0.034835212,
-0.04234349,
-0.023731986,
0.020521734,
0.0007644247,
-0.002903487,
0.01696658,
0.0022451866,
-0.013000194,
-0.0014708127,
-0.0046595084,
-0.0017875266,
-0.0051138517,
-0.015586967,
0.007004186,
-0.017284952,
0.02292279,
0.024381995,
-0.009464937,
0.010519545,
0.040247537,
-0.007972567,
0.008682272,
-0.017536996,
-0.028069805,
-0.025575891,
-0.010519545,
-0.021742161,
-0.0050276257,
0.016144117,
-0.018452317,
0.016674738,
0.011043532,
-0.002364576,
-0.018372722,
-0.0114812935,
0.022286046,
0.004178634,
0.00790624,
-0.00042449613,
0.019513557,
-0.025735077,
-0.01581248,
-0.030218817,
-0.015945135,
0.031226996,
-0.00062223506,
-0.019155387,
0.01619718,
0.012118038,
0.0016755989,
0.0028089704,
-0.009829738,
-0.0043742997,
-0.035127055,
-0.01846558,
0.034622964,
-0.017881898,
0.0037242903,
0.01723189,
-0.04000876,
0.0017029591,
-0.0045633335,
-0.023493208,
-0.020641124,
0.007475111,
0.004861807,
-0.026000388,
0.025204457,
0.038310774,
-0.01171344,
-0.017072704,
0.004586548,
-0.0020146985,
-0.007999099,
0.0029747891,
-0.023811579,
0.027565718,
0.04475781,
0.003906691,
-0.0004551726,
-0.0015247038,
-0.0028802725,
-0.0044837403,
-0.008145019,
0.0033445652,
0.00058368215,
0.01829313,
-0.013152747,
-0.011560886,
-0.021636037,
-0.004692672,
0.009378711,
0.023373818,
-0.007720523,
0.024368731,
0.021012558,
-0.0020030912,
-0.00582024,
0.011839462,
-0.049666047,
-0.025987122,
-0.0069378586,
-0.0069378586,
-0.016356366,
0.019394167,
-0.02897186,
-0.035976045,
0.0008547959,
-0.0051204846,
0.0068582655,
-0.011919055,
0.0014766164,
-0.006420504,
-0.008410329,
-0.0064768824,
-0.008887888,
-0.024740165,
-0.016117588,
-0.010963939,
-0.04231696,
-0.0034291327,
-0.0075878683,
-0.021874815,
0.005594726,
-0.010028721,
-0.012403246,
0.01602473,
-0.007561337,
0.0021108733,
-0.016117588,
-0.0013066521,
-0.008828193,
-0.04502312,
0.0031571898,
-0.00026551736,
0.009551163,
0.012708353,
0.0063143796,
0.010207805,
0.0027641994,
-0.003863578,
-0.012277224,
-0.016913516,
-0.011414966,
0.04319248,
0.020336017,
0.04844562,
-0.020044176,
0.017974759,
0.027194282,
-0.014976754,
0.026796317,
0.0012560774,
0.0144593995,
0.014379806,
-0.010366991,
-0.024315668,
0.013477752,
-0.014525726,
0.019991115,
0.031996395,
-0.022299312,
0.0017808939,
-0.017338013,
0.008947582,
-0.010685363,
-0.004215114,
-0.01808088,
0.005239874,
-0.0026215953,
-0.009285852,
-0.0013688342,
-0.002981422,
-0.0014699836,
0.020044176,
-0.0022551357,
-0.016979845,
-0.0014426236,
-0.013179278,
-0.003933222,
-0.014154293,
-0.016820658,
0.03608217,
0.009199627,
0.006924593,
0.0186513,
-0.0027376683,
0.046137422,
0.007461846,
0.019659476,
-0.015387984,
0.02133093,
-0.0046097627,
0.01814721,
0.010134845,
0.019022733,
0.028945329,
0.009783309,
0.051390562,
-0.016979845,
0.004281441,
0.024647307,
0.0032682884,
-0.016449224,
0.011865993,
0.0021125316,
0.017921695,
0.013577243,
0.005452122,
0.0034191837,
-0.007873077,
0.007647563,
-0.046827227,
-0.012462941,
0.011739971,
-0.017696181,
0.009186361,
0.0044572093,
0.03109434,
0.021808488,
-0.004118939,
-0.028282054,
0.00222363,
-0.017351279,
0.0012477865,
-0.015374719,
0.038788334,
0.012834375,
-0.0069909203,
-0.006397289,
-0.00920626,
0.011826197,
-0.000009456853,
-0.012409879,
0.026318759,
-0.009710349,
-0.0061717755,
0.028865736,
0.020694185,
0.021781957,
-0.021795223,
-0.029157577,
0.022936055,
0.020481938,
-0.027618779,
-0.03029841,
-0.042476144,
0.02354627,
-0.0044936896,
0.003750821,
0.0019085744,
0.029847383,
-0.013756327,
0.003140608,
-0.014923692,
-0.02304218,
0.015494108,
-0.0134512205,
0.03128006,
0.0046064463,
0.0034622964,
0.015586967,
-0.0053062015,
-0.017444137,
0.032818858,
-0.0061087646,
0.010221071,
-0.026862646,
-0.007859811,
-0.03976998,
0.02038908,
-0.020680921,
-0.021052355,
-0.0016714535,
-0.019367635,
-0.02038908,
0.0048651234,
0.00050864916,
0.0098098405,
-0.013437956,
-0.018107412,
-0.010811386,
0.012204263,
0.0021937827,
0.021463586,
0.027048362,
-0.007269496,
0.03427806,
-0.019341104,
0.0037276065,
0.0064901477,
-0.019380901,
0.028228993,
-0.010294031,
-0.011726705,
-0.03337601,
0.01060577,
0.00044232165,
0.002178859,
0.025602423,
0.011070063,
-0.007747054,
-0.005064106,
0.011076695,
0.013046623,
-0.005916415,
0.031253528,
0.03560461,
-0.0060391207,
0.00073001726,
0.0023678925,
0.038576085,
0.007912873,
-0.021755425,
0.0054720202,
0.00087883964,
0.018452317,
0.018133944,
-0.015839012,
-0.039133236,
0.0067521413,
0.03138618,
-0.0015048056,
0.01725842,
-0.010997103,
-0.010446584,
-0.006165143,
0.0005364238,
0.022670746,
-0.008828193,
0.024448324,
-0.0017891849,
-0.015374719,
-0.0020777094,
0.045978237,
-0.017324748,
-0.0019616364,
-0.01713903,
-0.0037906177,
-0.012204263,
-0.02145032,
-0.0084368605,
-0.0066824974,
-0.008934317,
-0.01311295,
-0.014379806,
0.0032583394,
0.018067617,
-0.005219976,
-0.009571061,
-0.009053706,
-0.014446134,
-0.039557733,
-0.015056347,
-0.015334923,
-0.03260661,
-0.041467965,
-0.048817053,
0.017868634,
0.041972052,
0.019805398,
-0.021874815,
-0.0149369575,
0.045686394,
-0.0154145155,
-0.0032500485,
-0.007992466,
-0.019845193,
-0.036427073,
0.019805398,
0.022949321,
0.029794322,
-0.027724903,
-0.011998648,
0.0068383673,
-0.005219976,
0.0013472778,
-0.029024921,
-0.011308842,
0.006775356,
0.025602423,
0.03133312,
0.0017527047,
-0.0023678925,
-0.014101231,
-0.037833218,
-0.012045077,
-0.026836114,
0.004152103,
-0.0011673643,
-0.0068648984,
0.027963681,
-0.015746154,
0.014379806,
-0.004669457,
-0.027061628,
0.014313479,
-0.01894314,
0.01019454,
0.029024921,
0.006092183,
0.018916609,
0.0035551551,
0.020680921,
-0.010400155,
-0.003220201,
0.026875911,
-0.0070506153,
-0.008045528,
0.025655484,
-0.0053062015,
-0.018677829,
-0.008145019,
0.0073822527,
-0.008549618,
0.022564622,
-0.012131304,
-0.03661279,
-0.0072296998,
-0.0033395905,
-0.00035713223,
0.0140747,
0.0064437184,
0.009584326,
0.0025801405,
0.003449031,
0.017828837,
-0.02371872,
0.012409879,
-0.03183721,
-0.0266106,
0.008596047,
-0.00068400253,
0.017178828,
0.011176187,
-0.0081383865,
-0.018492112,
-0.005196761,
-0.00555493,
-0.027247345,
-0.0068582655,
-0.006519995,
0.041149594,
0.012595596,
0.049108896,
0.0011856044,
0.017616589,
-0.005269721,
0.024501385,
-0.01971254,
-0.008463391,
0.011992016,
-0.014260417,
0.022551356,
0.014194089,
-0.00908687,
0.021437054,
-0.009843004,
0.004861807,
0.03369438,
0.000864745,
-0.032182112,
0.012449675,
-0.032765795,
0.0042913905,
0.005644472,
-0.012721618,
-0.01448593,
-0.035127055,
0.0033677798,
0.00418195,
0.008635843,
0.01831966,
-0.00783328,
0.045394555,
-0.012091506,
0.034304593,
-0.010234336,
0.013663469,
-0.018306395,
0.0038237814,
-0.0041288882,
0.008005732,
0.030908624,
-0.0030112693,
0.0059462623,
0.00012249863,
-0.001659017,
-0.0024806492,
0.010095049,
-0.02841471,
-0.014817568,
-0.014194089,
-0.03849649,
-0.0154145155,
-0.021888081,
-0.006705712,
-0.029104516,
0.014963488,
0.0032434156,
-0.016528817,
0.0136899995,
0.007747054,
-0.007727156,
0.046376202,
0.022524826,
0.014804302,
-0.027247345,
0.017338013,
-0.016329834,
0.006791938,
0.012854273,
-0.014114496,
-0.021025823,
0.0049414,
0.039637323,
0.04000876,
-0.020282956,
-0.012721618,
0.002338045,
-0.022962587,
-0.0066460175,
-0.048259903,
-0.0032185428,
0.010300663,
0.021171745,
0.0004551726,
0.0058799344,
0.0056146244,
0.013132849,
-0.0084368605,
-0.000045703808,
0.008251144,
-0.017430872,
-0.011613948,
0.016555348,
-0.001552064,
0.026650397,
0.0073424564,
-0.03793934,
0.021145213,
-0.012277224,
0.009020543,
0.005846771,
-0.0066393847,
0.025748342,
-0.007813382,
-0.00076193735,
0.021927878,
0.007985833,
-0.018837016,
-0.026040183,
0.0053592636,
0.0403006,
0.0037607704,
0.011454763,
-0.016608411,
0.009610858,
0.019805398,
-0.008125121,
0.0058268723,
-0.0009534581,
-0.029926976,
-0.001579424,
0.027698372,
-0.010360358,
0.011030266,
-0.015839012,
-0.022737073,
0.00829094,
-0.014194089,
-0.015679825,
0.020481938,
-0.052425273,
-0.025721813,
-0.003767403,
0.01395531,
0.012064976,
0.006685814,
0.009590959,
0.00052440196,
0.032553546,
0.011965484,
0.008357268,
0.014684913,
-0.025390174,
-0.01843905,
-0.0031538736,
0.006430453,
-0.0032832122,
0.00923279,
0.0035418896,
-0.026756521,
0.021118682,
0.004480424,
0.010300663,
0.011527723,
-0.035206646,
-0.0008771814,
0.006758774,
0.007534806,
-0.012860906,
-0.0077072578,
0.0050077275,
-0.038098525,
-0.0051702303,
0.03133312,
-0.020627858,
-0.010101682,
-0.012031812,
-0.01853191,
-0.0072562303,
-0.020481938,
-0.0069643897,
-0.004022764,
-0.019606415,
0.0006736389,
0.005372529,
0.022684012,
-0.023320755,
-0.010473115,
-0.007475111,
0.0126751885,
-0.0151757365,
-0.006758774,
-0.0025635585,
0.029343294,
0.024620775,
-0.01894314,
-0.0035883188,
0.0013447904,
-0.041016936,
-0.034994397,
0.003873527,
0.0010123238,
0.048949707,
-0.009179729,
-0.020468673,
-0.016568614,
-0.028282054,
-0.027061628,
-0.018545175,
0.0013166013,
0.003757454,
0.018571705,
0.029873915,
0.0055184495,
-0.0016565297,
0.011348639,
0.013298668,
0.005704167,
-0.013676735,
0.036718916,
-0.008085324,
0.005458755,
0.011607315,
-0.04897624,
-0.00081873033,
0.041229185,
0.0048385924,
0.0012096481,
0.026504476,
0.014472664,
-0.0034987766,
0.011487926,
0.007461846,
0.00029039016,
0.021198275,
0.022365639,
-0.028043276,
-0.021543179,
0.0056676865,
0.01920845,
-0.008828193,
0.010114946,
-0.0012511028,
-0.018054351,
0.029820852,
-0.01870436,
-0.009199627,
0.00904044,
-0.025443235,
0.018664563,
0.02121154,
0.025721813,
0.046455793,
0.017218623,
-0.016489021,
-0.01091751,
-0.026040183,
-0.039637323,
-0.01829313,
0.0040890914,
0.010008822,
-0.002726061,
0.021437054,
-0.0075812354,
-0.011308842,
-0.014684913,
0.020521734,
-0.00060482405,
-0.026026918,
0.015613498,
0.0053128344,
0.00870217,
-0.027539186,
0.012562432,
-0.014260417,
-0.017192094,
0.00809859,
0.005127117,
-0.019195184,
0.008662374,
-0.0049977787,
-0.02528405,
0.010599137,
-0.019288043,
-0.0005480311,
-0.008602679,
0.017948227,
0.18072923,
-0.0046959883,
-0.014021638,
0.014658381,
-0.012880804,
-0.024090154,
0.016688004,
0.010234336,
0.0010554367,
-0.006112081,
0.0074419477,
-0.009517999,
0.00068483164,
-0.0014915401,
0.0163431,
0.011846095,
-0.017497199,
-0.012847641,
-0.011574152,
0.00009125216,
-0.0029316763,
-0.012907336,
0.035949517,
0.0002524591,
0.009730247,
0.00635086,
-0.024620775,
-0.011799665,
-0.016051259,
0.030404534,
-0.041521028,
0.019805398,
0.0028620325,
-0.017072704,
-0.0035949515,
-0.0021374044,
-0.0040957243,
-0.0012552483,
-0.002460751,
0.01646249,
0.010439952,
-0.025920795,
0.007700625,
0.0018936506,
-0.0073092924,
0.0118991565,
-0.0009932546,
-0.0121379355,
-0.014313479,
-0.0021407206,
-0.05953558,
0.00023877907,
0.020070707,
0.03685157,
-0.010678731,
-0.002709479,
0.004321238,
0.010698629,
-0.008589414,
0.013265504,
-0.02026969,
-0.0019599781,
-0.03629442,
0.0136899995,
-0.0046362937,
0.0056411554,
-0.004042662,
0.024700368,
0.04160062,
-0.034676027,
-0.0009211234,
0.003863578,
0.0021158478,
-0.027990213,
0.014127761,
-0.020627858,
0.04213124,
0.00030241202,
0.028335117,
0.021662567,
-0.0053526307,
0.008901153,
-0.010081783,
-0.0064238203,
0.005734014,
-0.023612596,
0.014194089,
0.00022654994,
0.00296484,
-0.013252238,
0.006791938,
-0.009259322,
0.0016358024,
-0.015772684,
-0.0061850413,
0.015892074,
0.00060482405,
-0.008237878,
-0.019672742,
-0.014499196,
-0.023891171,
0.05481306,
0.024395261,
-0.002495573,
-0.013205809,
-0.0018223486,
0.0053260997,
0.009723614,
0.004719203,
-0.025032006,
0.023254428,
-0.021649303,
0.0136899995,
0.0002549464,
-0.016369632,
0.011938954,
0.01053281,
-0.03581686,
0.0262259,
-0.002144037,
-0.00026759008,
-0.03393316,
0.012834375,
0.024050359,
0.00056046754,
0.017364545,
-0.0071501066,
-0.004901604,
-0.00043029978,
-0.018492112,
-0.00004648108,
0.0006612025,
0.0019649528,
0.007932771,
-0.0019102326,
-0.010473115,
0.029051453,
-0.022206454,
-0.0011889208,
-0.020123769,
0.007521541,
-0.0063143796,
0.004623028,
0.012045077,
-0.0036148499,
-0.018664563,
0.006281216,
0.025748342,
-0.0395312,
-0.02607998,
0.00043112886,
-0.008795029,
0.010857815,
0.00037785957,
-0.00010964768,
-0.024567712,
-0.012303755,
-0.03531277,
-0.0009998874,
0.02227278,
-0.028043276,
0.016661473,
0.005770494,
-0.00071343535,
-0.0043378198,
-0.0066725486,
-0.16576573,
0.0054222746,
0.010280766,
-0.009332282,
0.026066715,
0.019792132,
0.0034059181,
0.023002384,
0.007747054,
-0.00388016,
-0.0026365188,
0.025735077,
-0.029847383,
-0.040380195,
-0.0017162246,
0.020309485,
-0.00024644818,
0.01740434,
0.014313479,
0.004894971,
0.0037077083,
-0.040114883,
0.0073092924,
-0.0073358235,
-0.01564003,
0.012947132,
-0.021423789,
0.0021009243,
-0.0005074055,
-0.020548265,
-0.014180823,
-0.0056312066,
0.014154293,
0.012628759,
0.028308585,
0.0070439824,
-0.013650203,
-0.014857364,
0.0068317344,
0.01053281,
0.021291133,
0.030404534,
0.018359458,
0.011401701,
0.011222616,
0.04534149,
-0.029820852,
-0.0003674959,
0.006931226,
-0.008397064,
0.024965677,
-0.0044240453,
0.011647113,
0.00024665546,
0.027008565,
0.024886085,
0.0015404567,
0.02714122,
0.0043112887,
0.0047589997,
0.009537897,
-0.012642025,
0.016886987,
-0.02607998,
-0.011494559,
-0.015082878,
-0.010473115,
0.025244253,
-0.036427073,
0.016502287,
-0.010791487,
0.015348188,
0.013298668,
-0.0065597915,
0.020442141,
0.007508275,
-0.0040360293,
0.014897161,
-0.0018654615,
-0.0005185983,
-0.019805398,
0.041255716,
-0.017444137,
-0.018425785,
-0.010128212,
-0.008808294,
0.010141478,
0.008052161,
0.01619718,
0.0044671586,
-0.0056477883,
-0.031518836,
0.023387084,
-0.016104322,
0.046535388,
0.012409879,
-0.011355272,
-0.019686008,
0.0067222943,
-0.013106318,
0.0019069161,
0.004331187,
-0.022697277,
0.030590251,
0.047304787,
0.009756778,
0.0029664983,
0.0010728476,
0.013875717,
-0.0032168846,
-0.006924593,
-0.013530814,
0.018598236,
0.025562625,
0.002213681,
0.0384169,
0.009312384,
0.0072827614,
-0.000004359221,
-0.009073605,
0.07338477,
-0.0017029591,
-0.02617284,
-0.0027741485,
0.001367176,
-0.014326744,
-0.114083335,
-0.006500097,
0.0053692125,
0.051231377,
-0.020123769,
0.01564003,
-0.0058036577,
0.037196472,
0.0018223486,
0.019606415,
-0.03138618,
0.0014608636,
0.009073605,
-0.0053493143,
-0.017616589,
-0.02921064,
-0.0112425145,
-0.024474854,
0.0036911264,
0.012423145,
0.008715436,
0.0031008115,
-0.023373818,
-0.014353275,
0.01501655,
-0.0055914097,
-0.027884088,
0.040672034,
0.009365446,
0.008828193,
-0.0029001709,
-0.020508468,
0.020229893,
0.0055449805,
-0.040433254,
-0.008635843,
-0.029316762,
-0.020070707,
0.010632302,
-0.02477996,
-0.013623673,
0.006042437,
0.032208644,
-0.01000219,
0.019380901,
0.0031207097,
-0.011793033,
0.007992466,
0.0044505764,
0.0090338085,
-0.013331831,
-0.0046727736,
-0.029396357,
-0.010234336,
0.008410329,
-0.017457403,
0.009478202,
0.004490373,
-0.017948227,
-0.00017276246,
-0.013809389,
0.008383798,
0.009816472,
0.0105261775,
0.023652393,
-0.0057472796,
-0.012801211,
-0.022975853,
0.019686008,
-0.013026725,
-0.011202718,
0.009192994,
-0.022445232,
0.0051105353,
-0.036745444,
-0.0029515745,
-0.032553546,
-0.030218817,
0.019394167,
0.005276354,
-0.022684012,
-0.03263314,
0.012754782,
-0.028839204,
0.044678215,
0.0003519504,
-0.009697083,
0.009378711,
0.00915983,
-0.004957982,
-0.007196536,
0.022644214,
0.0018638032,
-0.0092725875,
-0.017842103,
0.016979845,
-0.005916415,
-0.0001263332,
0.022339107,
0.0030676478,
-0.038284242,
0.010552708,
-0.06441729,
0.013272136,
0.017192094,
-0.017218623,
-0.006045753,
-0.008994011,
0.005787076,
-0.00718327,
-0.0027509339,
0.031518836,
-0.02740653,
0.011766502,
-0.002046204,
-0.007820015,
-0.029900445,
-0.010718527,
0.044916995,
-0.026040183,
0.012078241,
0.020468673,
-0.018372722,
-0.0021871498,
0.03581686,
0.033906627,
-0.018982936,
0.005574828,
-0.006244736,
0.0197656,
0.0018472214,
0.017324748,
0.02501874,
-0.042794514,
-0.020641124,
0.015825747,
-0.00046470718,
-0.01894314,
-0.028308585,
0.035365835,
0.004235012,
0.039876103,
-0.012721618,
-0.0269953,
-0.011375169,
0.018903343,
-0.016674738,
-0.003598268,
-0.012854273,
0.0013779541,
-0.0026215953,
-0.016369632,
0.036718916,
-0.0023048813,
0.02735347,
-0.03557808,
-0.0117200725,
0.005903149,
0.01696658,
-0.0040824586,
0.00058782764,
-0.044121064,
0.012562432,
0.02870655,
0.015679825,
0.009949128,
-0.010824651,
-0.0059495782,
-0.022246249,
-0.0041288882,
-0.021543179,
-0.052080367,
-0.014207355,
0.019606415,
0.007866444,
0.0018505377,
-0.023904437,
0.0025420021,
-0.012489472,
-0.01566656,
-0.006234787,
0.0011068404,
0.019009467,
0.012383347,
-0.010366991,
-0.0028437923,
0.01776251,
-0.0067720395,
-0.015533905,
0.05300895,
0.009385344,
0.0058998326,
-0.017099235,
0.010731793,
0.031253528,
-0.0012005281,
0.010572607,
0.013550712,
-0.024023827,
0.0089741135,
0.008542985,
0.009338914,
-0.003634748,
-0.006765407,
-0.0026133042,
-0.007455213,
-0.0136899995,
0.03661279,
-0.03472909,
-0.019805398,
0.008251144,
-0.014233885,
0.015480842,
0.02103909,
0.020893168,
-0.011030266,
-0.009789942,
-0.0047490504,
0.01487063,
-0.025774874,
0.007475111,
0.02265748,
0.02304218,
0.029077984,
-0.015228799,
0.006791938,
0.041149594,
0.020176832,
0.007780218,
-0.03106781,
0.033084165,
-0.007561337,
0.031731084,
0.015348188,
-0.030431066,
-0.013292035,
-0.01236345,
-0.0026829483,
0.0048087453,
-0.0073689874,
-0.011395068,
0.09376058,
0.011215984,
-0.017483935,
0.021556444,
-0.016674738,
0.010015455,
0.006500097,
-0.021636037,
-0.01896967,
-0.037514843,
-0.00028127013,
-0.0035054095,
0.025602423,
-0.007262863,
0.008808294,
0.016542083,
0.00029391382,
0.019871725,
-0.012867538,
-0.03292498,
0.0043676673,
-0.02552283,
0.00908687,
0.03348213,
0.0019284727,
0.0054919184,
0.021012558,
0.009259322,
0.021874815,
-0.03897405,
0.013875717,
-0.027698372,
-0.02321463,
-0.011773135,
0.007249598,
-0.00222363,
0.011998648,
-0.015295126,
0.028573895,
0.023241162,
-0.0014492563,
-0.017735979,
0.0006296969,
-0.0059926915,
0.016674738,
0.005219976,
0.01646249,
-0.013915514,
-0.025416706
] |
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes. Each tissue has its own composition of embryonically derived and adult-derived macrophages, but it is unclear whether macrophages of distinct origins are functionally interchangeable or have unique roles at steady state. This new understanding also prompts reconsideration of the function of circulating monocytes. Classical Ly6c(hi) monocytes patrol the extravascular space in resting organs, and Ly6c(lo) nonclassical | [
-0.02696416,
-0.008046386,
-0.010942825,
-0.03808233,
-0.012131275,
0.0076956963,
-0.013637942,
0.012949551,
-0.03187382,
0.0038121296,
0.016313577,
-0.027691517,
0.011722136,
0.0029630053,
-0.02854876,
0.01081294,
0.034991063,
0.0011730255,
-0.031588074,
-0.004146584,
-0.01918404,
0.028418874,
-0.014066564,
-0.020859558,
-0.007825581,
0.04036831,
0.023691054,
-0.014443231,
-0.0069943164,
-0.013508057,
-0.0065332237,
-0.009916732,
-0.025613355,
-0.012936562,
0.0031351033,
-0.014170472,
0.027743472,
-0.007994432,
0.023652088,
0.0032942125,
0.01830082,
0.003341296,
-0.007189144,
-0.002665893,
0.011429895,
-0.0050687687,
-0.018326797,
-0.003079902,
-0.012988517,
0.014690013,
0.02276887,
0.0006571378,
0.005581815,
0.0178722,
-0.03387405,
0.005399976,
-0.031302325,
0.015248518,
-0.008552938,
-0.031640027,
-0.0049129063,
-0.0013280758,
-0.013170356,
-0.009923227,
-0.004922648,
0.018339785,
-0.00077159907,
0.011475354,
0.011741619,
0.009475123,
0.030289222,
0.005786384,
0.00575716,
0.015014725,
-0.0007277628,
-0.027457723,
-0.017014956,
0.011475354,
0.0018297572,
-0.022158409,
-0.002576597,
-0.033484396,
0.003341296,
0.043043945,
0.013248287,
-0.0098777665,
0.0155082885,
0.00884518,
0.012507942,
-0.0075073624,
0.028756576,
0.03387405,
0.015391393,
0.010793458,
-0.0066501205,
0.017586451,
-0.008773743,
0.03091267,
-0.016586335,
-0.021171283,
-0.022457145,
0.021911627,
-0.022353237,
-0.019106109,
-0.040420264,
-0.0016803894,
0.009130927,
-0.0087088,
0.026379677,
0.00010857588,
-0.027483702,
0.03013336,
0.014897829,
-0.028678644,
0.010462251,
0.013027482,
0.023691054,
0.006942362,
0.0067865,
0.003016583,
0.0016568477,
0.025990022,
0.005425953,
-0.025964044,
0.031406235,
0.0068774195,
-0.018885303,
-0.006036413,
-0.028055197,
0.012046849,
-0.0069943164,
-0.0026301746,
0.012813171,
0.018080015,
-0.019677604,
0.001401948,
-0.02583416,
0.013741851,
-0.010884377,
-0.02548347,
-0.011332481,
0.024470365,
-0.015417369,
-0.00078661705,
-0.0009270554,
0.03667957,
0.039433137,
0.013059953,
0.014508173,
0.014586104,
-0.0014595846,
-0.011501332,
0.021353122,
-0.033770144,
0.0031675745,
-0.005932505,
-0.015209553,
0.020015305,
-0.016040819,
-0.0011722136,
0.008423053,
-0.019391855,
0.026210826,
0.016963003,
0.019093119,
0.008247708,
0.0022989674,
0.036004167,
0.0034127329,
-0.0037114685,
-0.01340415,
0.016079783,
-0.006948856,
0.008598398,
-0.0014376665,
0.013352195,
0.00444532,
0.008065869,
-0.0402644,
-0.021327144,
0.0020521856,
0.01317685,
0.022638984,
-0.0016170703,
-0.011312998,
0.00236391,
0.031666003,
-0.0059487405,
0.01203386,
-0.02206749,
-0.0041887965,
0.03135428,
-0.0007277628,
-0.016937025,
-0.6359178,
-0.013241793,
0.0012420269,
-0.013689896,
-0.016131738,
0.0146770235,
0.006844948,
-0.026652437,
-0.0190022,
0.016131738,
-0.028626692,
0.017976107,
0.020417947,
-0.013300241,
-0.011325986,
-0.03356233,
-0.019300936,
-0.0031886809,
0.008637364,
-0.0154953,
-0.026171861,
-0.007312535,
-0.008487996,
0.007286558,
-0.022742894,
0.011371447,
0.024405424,
0.017976107,
-0.021898638,
0.047174294,
-0.008624375,
0.015884956,
-0.017651394,
-0.010124548,
0.041952908,
0.009014031,
-0.028496806,
0.02732784,
0.0014969265,
0.0048706937,
0.004679113,
-0.015690127,
0.0075008683,
-0.016651278,
-0.013585988,
0.0008669835,
-0.0066696033,
-0.004802504,
0.002699988,
0.0043089404,
-0.015807025,
-0.004130348,
-0.011585757,
0.001897947,
0.007526845,
-0.0024434647,
0.019456798,
0.0057409243,
0.0030896433,
0.01033886,
0.0014717613,
0.010481733,
-0.01287162,
-0.010981791,
-0.011235067,
0.020378983,
-0.027379792,
-0.013287253,
0.015001737,
0.00613058,
0.017807256,
0.02688623,
-0.0020960218,
0.002024585,
-0.007286558,
0.025977034,
0.0051207226,
-0.004127101,
0.015391393,
0.01348208,
0.0002934593,
-0.00002125855,
0.0050200615,
0.026678413,
0.028392898,
-0.010163514,
-0.025535423,
0.011325986,
0.014443231,
0.028522782,
-0.0031415974,
0.017352657,
-0.0005134523,
-0.046732683,
-0.019210016,
0.047174294,
-0.015794037,
-0.003068537,
0.033198647,
-0.008929606,
-0.028938415,
-0.005425953,
0.017183807,
0.0010821058,
0.03265313,
0.005377246,
-0.042082794,
0.001233909,
0.046628773,
-0.026106918,
0.021405075,
0.00005794096,
-0.004903165,
0.0029808646,
0.0018378751,
-0.017911164,
0.0021901885,
0.009845296,
0.0033120718,
-0.023704043,
0.011312998,
-0.013339207,
0.005432447,
-0.008377593,
0.033822097,
0.019651625,
-0.0036302905,
-0.023327377,
-0.0061208387,
-0.0071501783,
-0.010020641,
0.012313114,
0.021495994,
-0.014910817,
0.028340943,
0.016755186,
0.019937374,
0.008033398,
0.0018183923,
-0.03501704,
-0.024457376,
-0.021612892,
0.00091406686,
-0.021651857,
-0.016079783,
-0.010092078,
0.005731183,
-0.013066447,
-0.0062929364,
0.005981212,
-0.005396729,
0.01567714,
-0.02652255,
0.0027811662,
0.022638984,
-0.0016324942,
0.0017177314,
-0.005750666,
0.0021577172,
0.008228226,
-0.03854992,
0.008585409,
-0.0002524643,
0.021781743,
-0.009254318,
-0.0042569865,
-0.029016346,
0.0053512687,
-0.007935984,
-0.042784173,
-0.010449261,
-0.0046206648,
-0.019768523,
0.0072086267,
-0.0040102047,
-0.009065985,
-0.00006402933,
-0.0100661,
-0.0022778611,
-0.020067258,
0.007760639,
-0.016235646,
0.007409949,
-0.008384087,
0.039511066,
0.0074034543,
0.026015999,
-0.018118981,
0.019742545,
0.047589924,
0.005750666,
0.00896857,
-0.02758761,
-0.00046190413,
0.016430473,
-0.04894073,
-0.0054454356,
0.018002084,
0.024028756,
0.01601484,
0.0017924153,
-0.011871505,
0.007267075,
-0.020028293,
-0.003519888,
-0.038835663,
-0.009143916,
-0.00400371,
0.004023193,
0.012293631,
-0.010799952,
0.0069813277,
0.010838917,
-0.022522088,
0.013111908,
0.021755766,
-0.0034354627,
-0.025717262,
-0.0014847498,
-0.011442883,
0.014767943,
-0.014806909,
0.024652205,
-0.000029071953,
-0.010092078,
0.005737677,
0.015768059,
0.0071112127,
-0.029406002,
-0.011488343,
0.0058221025,
0.011046734,
0.010182997,
0.007825581,
0.0057896315,
-0.0023882636,
0.0013223933,
-0.018118981,
0.027509678,
-0.010741503,
0.010929837,
0.012176734,
0.017469555,
-0.00061127206,
-0.018248865,
-0.013287253,
0.00989725,
0.0045264983,
-0.0019499011,
0.007319029,
-0.009617996,
-0.011761102,
-0.0062669595,
0.003870578,
-0.002829873,
0.016404497,
0.014482196,
-0.0038608366,
0.03387405,
0.012624838,
0.0014547139,
-0.011131159,
-0.021418065,
-0.023392318,
0.013066447,
-0.009091961,
0.0046888543,
-0.025769217,
-0.015079668,
-0.0052311253,
-0.045901418,
0.01265731,
0.027301863,
-0.032679107,
0.024924964,
0.017443579,
0.02880853,
-0.013702885,
0.017885188,
0.003191928,
-0.024119675,
-0.02984761,
0.0137158735,
0.0341598,
-0.012897597,
-0.0019287947,
-0.017235762,
-0.01872944,
-0.009481617,
0.013637942,
0.0075852936,
-0.0011527309,
-0.008988054,
-0.01961266,
-0.040290378,
0.0060234247,
0.028912438,
0.0012314738,
0.017118866,
0.012696275,
0.0071112127,
-0.008169777,
-0.012124781,
-0.021223236,
0.029146232,
0.012611849,
0.002472689,
0.0056727347,
-0.0138457585,
-0.0023363095,
-0.01497576,
-0.008819203,
0.015690127,
-0.0020197143,
-0.01462507,
0.015105645,
-0.013092425,
0.028522782,
0.043927163,
-0.010754492,
-0.00070259755,
-0.026600482,
-0.0021755765,
-0.017196797,
0.036315892,
0.00805288,
-0.00023622865,
0.0007184273,
-0.00044810382,
0.005646758,
-0.013430126,
-0.0025701027,
0.034965087,
0.0005540414,
-0.0067215576,
-0.015027714,
0.0012647568,
-0.00470509,
0.0076892017,
0.014754955,
0.0008970194,
0.0034581926,
-0.014767943,
-0.015664151,
0.017196797,
0.0054389415,
0.039537046,
0.02406772,
0.016261622,
0.007903513,
-0.0060266717,
-0.0002654528,
-0.009650468,
-0.01680714,
-0.024561284,
0.031302325,
-0.008994548,
0.004497274,
-0.008975065,
-0.012507942,
-0.014703001,
-0.0035491122,
0.019054154,
-0.00234118,
0.0121832285,
0.03010738,
0.010786963,
-0.0076892017,
0.015768059,
0.013650931,
0.009280295,
0.016300589,
-0.0003977733,
-0.006708569,
0.031717956,
-0.021755766,
-0.0045427335,
-0.032912903,
0.037510835,
0.0031415974,
0.0056662406,
-0.0077801216,
-0.01874243,
0.005380493,
0.0041076182,
-0.020651741,
0.007910007,
-0.016313577,
0.0073579946,
-0.030886693,
0.0031610802,
-0.00374394,
-0.018547602,
0.008436042,
0.023483237,
-0.02539255,
0.00074846327,
-0.0069943164,
0.008643858,
0.032445315,
0.027535655,
-0.016612314,
0.021210248,
0.02836692,
0.010046618,
-0.017755302,
-0.017300704,
-0.043095898,
-0.0090465015,
-0.01804105,
0.012507942,
-0.009981675,
-0.008559433,
-0.007156673,
0.013962655,
-0.010397308,
0.0028850744,
0.0147419665,
-0.039329227,
0.0014295486,
0.016404497,
0.013072942,
-0.006205264,
-0.027509678,
-0.0155082885,
-0.014209437,
-0.024548296,
-0.0074813855,
-0.020885535,
-0.008975065,
-0.00573443,
0.0037049744,
-0.019378867,
-0.010683055,
0.01996335,
-0.00374394,
0.0010009275,
0.015001737,
0.01575507,
0.020184156,
0.008767249,
0.008059375,
0.023015652,
-0.0062507237,
-0.004269975,
0.007033282,
0.018313808,
0.025158757,
-0.03704325,
0.0094946055,
-0.0056922175,
-0.01020248,
-0.017456567,
-0.0201322,
-0.014754955,
0.015287484,
-0.0016998721,
-0.015664151,
-0.010208974,
-0.008390582,
0.017976107,
0.012410528,
-0.012274148,
-0.0026382925,
-0.0036270432,
0.02048289,
0.0001737214,
-0.00011841874,
0.023781974,
-0.04135544,
0.010890871,
0.0139107015,
-0.0009765741,
0.025457492,
-0.019911395,
-0.00127531,
0.009163398,
0.02005427,
-0.021405075,
-0.024106687,
-0.01856059,
-0.0019856195,
0.036627617,
0.031146463,
0.004903165,
-0.006578684,
0.04553774,
0.017859211,
0.0019969845,
0.0032065401,
-0.000075749434,
0.008137305,
-0.015261507,
0.032055657,
0.014521162,
0.01195593,
-0.008267191,
-0.013163862,
0.009838802,
0.03836808,
-0.008150294,
-0.01453415,
0.0010049865,
-0.019508751,
-0.0318998,
0.01610576,
-0.012410528,
0.002297344,
-0.024405424,
-0.011858515,
0.024054732,
0.0012704392,
0.010020641,
-0.0010918472,
0.030834738,
-0.004006957,
0.01901519,
-0.019937374,
0.0040654056,
0.0050200615,
0.0002177606,
-0.010851906,
-0.015183576,
0.0025701027,
-0.007987938,
-0.009345238,
0.004799257,
-0.0017469554,
0.015183576,
0.0029256633,
-0.016768174,
-0.004347906,
-0.017196797,
-0.028211059,
-0.0067605227,
0.010605124,
-0.021495994,
-0.0201322,
-0.006591672,
0.017040934,
-0.0073774774,
0.015612197,
-0.0063708676,
-0.019690592,
0.024937952,
-0.00027458536,
0.027951287,
-0.0309906,
0.006682592,
0.018196912,
-0.011644205,
-0.014664035,
-0.018157946,
-0.0022600018,
-0.0045329924,
0.036367845,
0.009975181,
-0.01935289,
0.006510494,
0.012891103,
0.015521278,
-0.001125942,
-0.021249212,
-0.0011413659,
-0.0087932255,
-0.012540413,
-0.018937258,
0.0047148317,
-0.019716568,
-0.008397076,
-0.015716106,
0.0046596304,
0.0057928786,
0.00036144606,
-0.010936331,
0.033432443,
0.01506668,
-0.010481733,
0.013819782,
-0.0062020165,
-0.002125246,
-0.027483702,
-0.014456219,
0.010241445,
0.012468976,
0.0325752,
0.00003627652,
0.0015521278,
0.014521162,
0.0061695455,
-0.026054963,
-0.010754492,
-0.0020294557,
0.041017737,
-0.006562448,
0.021470018,
0.010131043,
0.026236804,
0.011215584,
-0.03660164,
0.004104371,
-0.0020115965,
0.003344543,
-0.008195754,
0.042680267,
0.006140321,
-0.019586682,
-0.013871736,
-0.028392898,
-0.008312651,
-0.036004167,
-0.04616119,
-0.0050687687,
-0.018430704,
-0.0022177892,
0.015599209,
0.0007561752,
0.02618485,
-0.015261507,
-0.005805867,
-0.027795425,
0.020768639,
0.014586104,
0.03686141,
0.00089133694,
0.019729557,
-0.022729903,
-0.008000926,
-0.02031404,
-0.03413382,
-0.007845064,
-0.020794615,
-0.038316123,
0.013066447,
-0.0005917893,
0.004854458,
0.00079838786,
-0.0059357523,
0.0051661823,
0.013819782,
0.023794962,
-0.00073019817,
-0.013443115,
0.032731064,
-0.026652437,
-0.029354047,
-0.004357647,
-0.0045557222,
0.0015099151,
0.008176271,
-0.0287306,
-0.007513857,
-0.00809834,
-0.020106224,
-0.036523707,
0.023444273,
-0.042082794,
-0.0010601877,
-0.021950593,
-0.019119097,
-0.0059000337,
0.001737214,
0.0052116425,
-0.019677604,
-0.01917105,
0.014508173,
0.00608512,
-0.01830082,
-0.015975876,
0.017833233,
0.012300125,
-0.0073255235,
-0.0056759818,
0.002665893,
-0.041900955,
0.05907177,
0.007539834,
0.0015691752,
0.0016195057,
0.025535423,
-0.050655216,
-0.054395907,
0.022924732,
0.031068532,
0.00079189363,
0.013241793,
0.021288179,
0.008273685,
0.00070787413,
-0.010494721,
-0.0069813277,
-0.023301398,
0.007072247,
-0.016417485,
0.017729325,
0.0072216154,
-0.022470133,
-0.024821056,
0.03135428,
0.010871388,
-0.004494027,
0.012462482,
-0.022898754,
0.019041166,
-0.010650584,
0.01037133,
-0.012774206,
0.002099269,
0.033484396,
-0.018482659,
0.009936215,
0.026912207,
-0.008059375,
-0.0086633405,
-0.011442883,
0.02066473,
0.003542618,
0.004601182,
-0.0019320418,
-0.027535655,
0.013300241,
-0.033666234,
0.027171977,
0.021599904,
-0.031717956,
0.015352427,
0.021846686,
-0.00818926,
-0.016872084,
-0.00818926,
-0.010637595,
0.0012818043,
-0.014508173,
0.002740577,
-0.0010342107,
0.0047700326,
0.007494374,
-0.026314735,
0.00025672614,
-0.01130001,
-0.0009270554,
-0.013611966,
0.009137422,
0.007241098,
-0.024041744,
0.00601693,
0.009325755,
-0.012741735,
-0.0244314,
0.0052441135,
-0.014339322,
-0.012637827,
0.0011949436,
-0.001987243,
0.004974602,
-0.023950825,
-0.012722252,
-0.023405306,
-0.006805983,
0.015040702,
0.1814236,
-0.0318998,
-0.0007030035,
0.018924268,
-0.015988864,
-0.024288526,
-0.0014230544,
0.0057214415,
-0.0088581685,
0.0154953,
0.024054732,
-0.006127333,
0.006387103,
0.005523367,
0.009117939,
-0.025288641,
-0.004357647,
-0.017664382,
-0.011579263,
-0.019482775,
-0.017287716,
-0.029717727,
0.007409949,
-0.012910586,
0.020547833,
-0.010890871,
-0.0124365045,
0.0065072468,
0.00007727153,
-0.015456335,
-0.006114344,
-0.0009465382,
-0.011183113,
0.016846105,
0.005003826,
0.015300472,
-0.009916732,
0.0045232507,
-0.00058367144,
-0.01348208,
0.013261275,
-0.014196449,
0.0011754608,
0.0123780565,
0.011741619,
0.031224394,
-0.017651394,
-0.009280295,
-0.018586567,
-0.008721789,
-0.043979116,
-0.000853995,
-0.0022713668,
0.02232726,
0.0038835665,
-0.0077346615,
0.007922995,
0.028055197,
-0.018521626,
0.020417947,
-0.020963466,
0.004016699,
-0.02511979,
0.007260581,
-0.011364952,
0.03221152,
0.0064293155,
-0.01776829,
0.0023915106,
-0.024184618,
0.0017420847,
-0.005149947,
-0.0014782555,
-0.023794962,
0.0047667855,
-0.006968339,
0.02644462,
0.0059942002,
0.0006279136,
0.017859211,
0.017755302,
-0.013585988,
-0.019391855,
-0.014443231,
0.0052506076,
-0.039511066,
0.034861177,
0.019132085,
-0.016534382,
-0.010546676,
-0.0023070853,
-0.027613586,
-0.0019677603,
-0.0059162695,
0.019521741,
0.0012542036,
0.006361126,
0.009605008,
-0.0074554086,
-0.014482196,
-0.024015767,
0.07496972,
0.022106456,
-0.014703001,
-0.013163862,
0.021937605,
-0.0023200738,
0.017365647,
-0.008981559,
-0.013819782,
0.011787079,
-0.040835895,
0.0043316702,
-0.011813056,
0.00823472,
0.04686257,
0.008773743,
-0.02870462,
0.03774463,
-0.0032390114,
-0.01601484,
-0.0026382925,
0.021638868,
0.008065869,
-0.00065429654,
0.005864315,
-0.027977265,
0.018339785,
-0.0055655795,
-0.024924964,
-0.018365763,
-0.0146770235,
0.0029971001,
0.027821403,
0.0012931692,
-0.0029971001,
0.004494027,
-0.021041397,
-0.017651394,
0.00003445001,
-0.017586451,
-0.005500637,
0.01830082,
0.012397539,
0.014495185,
0.009929721,
0.013858748,
0.019456798,
-0.014988748,
-0.012040355,
-0.022535076,
-0.021872662,
-0.010170008,
-0.011442883,
0.016937025,
-0.018586567,
-0.0051369583,
-0.021677835,
-0.0019028176,
-0.009682939,
-0.027535655,
0.008487996,
0.019781511,
-0.016300589,
-0.014404265,
-0.022457145,
-0.16074589,
0.010683055,
0.014638058,
-0.016521392,
0.018313808,
0.00045256864,
-0.006159804,
0.00040589116,
-0.016911048,
0.010657078,
0.040524174,
0.00030076533,
-0.039381184,
-0.024924964,
0.011942941,
0.0019060648,
0.013975644,
0.023301398,
0.014391276,
0.0015115386,
0.055902574,
-0.017131854,
0.008280179,
-0.0068774195,
-0.0025002894,
0.014508173,
0.009630985,
-0.00040467348,
0.0030230773,
-0.021937605,
-0.0056727347,
-0.008955582,
0.006935868,
0.01055317,
0.012696275,
0.01698898,
-0.0007464338,
-0.020262087,
0.008442536,
-0.01637852,
0.013170356,
0.02766554,
-0.01273524,
0.0028103902,
-0.007812593,
0.018118981,
-0.0078060986,
-0.024015767,
0.034289684,
-0.043927163,
0.0077086845,
0.000559318,
-0.00092218467,
0.02380795,
0.00006550068,
0.02566531,
0.011442883,
0.02293772,
0.018248865,
0.009001042,
-0.012306619,
-0.016975991,
0.02389887,
0.0051337113,
-0.00012471006,
-0.014027598,
0.0028444852,
0.02337933,
-0.006111097,
0.011968918,
-0.026535539,
-0.024041744,
0.014001621,
-0.01953473,
0.016131738,
0.023301398,
-0.0016414238,
-0.009955698,
0.0008889016,
0.012904091,
-0.0034257213,
-0.0043608947,
-0.026561517,
-0.008462018,
-0.013560011,
0.009117939,
0.013975644,
-0.011741619,
0.005325292,
-0.006263712,
0.0044063544,
-0.025795193,
-0.016339554,
-0.0039030493,
0.0190022,
0.03317267,
-0.01383277,
-0.023054617,
-0.022820823,
-0.002643163,
0.02495094,
-0.019950362,
-0.020872546,
0.026730368,
0.024756113,
-0.013456103,
-0.028964393,
0.003919285,
0.06187729,
-0.040576126,
-0.0038998022,
-0.014456219,
0.028522782,
0.020301051,
0.0031854338,
0.04187498,
0.015222541,
-0.011033745,
0.016975991,
-0.028496806,
0.062396836,
-0.0121832285,
-0.020119213,
0.038108308,
-0.0052148895,
-0.019599672,
-0.13611965,
-0.011696159,
-0.006000695,
0.0072800633,
-0.010293399,
0.024924964,
-0.008851674,
0.0040102047,
0.005640263,
0.017443579,
-0.017027946,
-0.010260928,
-0.0074748914,
-0.032783017,
0.0045622163,
-0.0031415974,
0.0038413538,
0.0006518612,
-0.016625302,
0.026938183,
0.02067772,
-0.018664498,
0.016456451,
-0.009540065,
0.009572537,
0.021781743,
-0.047875673,
0.019132085,
0.01584599,
0.005513625,
0.012124781,
0.012352079,
0.02566531,
0.0015740459,
0.015430357,
-0.011105182,
0.014806909,
-0.004218021,
0.026340712,
-0.025990022,
-0.016846105,
0.015547254,
0.018326797,
-0.023132548,
0.011105182,
-0.0040134517,
-0.031536117,
-0.005052533,
0.007260581,
-0.020508869,
-0.029276116,
-0.019248981,
-0.026067954,
-0.032731064,
0.015988864,
-0.002300591,
-0.011306504,
0.015534266,
0.0072800633,
0.0014327958,
-0.004805751,
-0.0036919857,
-0.007416443,
0.0010861647,
0.04062808,
-0.034809224,
0.005023309,
-0.01610576,
0.0011235067,
-0.050889008,
-0.00042862105,
0.0034419568,
-0.0040719,
-0.006215005,
-0.0014750084,
0.008806215,
0.006864431,
0.013547023,
-0.012787195,
-0.0015229036,
-0.00809834,
-0.018872315,
0.0066436264,
-0.01195593,
0.03888762,
0.026301745,
0.0032666118,
0.016027829,
0.028029218,
-0.013637942,
-0.0055915564,
0.03826417,
-0.0061468156,
-0.027509678,
0.017209785,
0.00610785,
0.024496343,
0.011624723,
0.018456683,
0.027795425,
-0.006682592,
-0.005023309,
-0.04034233,
0.022522088,
-0.008397076,
0.018677486,
-0.008000926,
-0.032341406,
0.0025489964,
-0.030081404,
0.011085699,
0.03670555,
-0.022522088,
-0.0009116315,
0.012988517,
0.0059195166,
-0.036757503,
0.0040134517,
0.0055460967,
0.017976107,
0.020911511,
0.02241818,
-0.00004553591,
0.013339207,
0.0058253496,
-0.012767712,
0.0048447168,
0.010592136,
-0.021560937,
0.0220545,
-0.011293516,
-0.0049875905,
-0.005153194,
-0.024639215,
-0.01200139,
0.016248634,
-0.013046965,
-0.026626458,
0.0016333059,
0.01479392,
0.0104557555,
0.03878371,
-0.02696416,
-0.034185775,
0.019197028,
-0.026080942,
-0.009312767,
0.007955466,
-0.00844903,
0.00779311,
0.0010195986,
-0.011189607,
0.062396836,
0.018378751,
-0.007526845,
-0.046654753,
-0.025730252,
0.0054584243,
0.03283497,
0.0062669595,
-0.017898176,
-0.024210595,
0.008832191,
0.029613817,
-0.011176619,
0.0023200738,
0.0049681077,
-0.02434048,
-0.013053459,
0.009280295,
0.00910495,
-0.01339116,
0.0067994883,
0.0076892017,
0.0048901765,
-0.01041679,
0.026600482,
-0.008637364,
-0.026327724,
0.018157946,
0.00017260521,
0.024509331,
-0.0062767006,
-0.011611734,
-0.012332597,
0.017755302,
0.030497037,
0.005396729,
-0.01059863,
0.040706012,
-0.023002664,
0.007565811,
-0.016248634,
0.022703927,
0.013754839,
-0.0065169884,
0.00468236,
0.015625186,
-0.009799836,
0.01339116,
-0.012748229,
0.049746018,
0.008520467,
-0.0032747297,
-0.00074521615,
-0.028938415,
-0.012163746,
0.0073255235,
-0.025288641,
-0.016975991,
-0.008812709,
0.0139107015,
0.007935984,
0.020469902,
0.0065754363,
-0.013936678,
-0.027379792,
0.0115467915,
0.0020879041,
-0.0170799,
-0.009403686,
0.03143221,
0.016846105,
0.014832886,
-0.006513741,
-0.015157599,
-0.005990953,
0.008884145,
0.034185775,
-0.012800183,
0.02040496,
0.010683055,
0.02486002,
0.0017144842,
-0.053252917,
-0.0041076182,
-0.005296068,
-0.03021129,
0.023535192,
0.037328996,
-0.009429663,
0.05595453,
-0.012280642,
-0.0263537,
0.018924268,
-0.029561864,
0.03283497,
0.022158409,
0.02950991,
-0.0062929364,
-0.009702422,
0.01059863,
-0.017105876,
0.03854992,
-0.024145652,
-0.021768754,
0.01891128,
-0.01418346,
0.010384319,
0.007033282,
-0.0041076182,
0.025522435,
-0.009910238,
0.0059487405,
0.0062702065,
-0.019028177,
0.009650468,
0.04930441,
0.0014141247,
0.01715783,
-0.02950991,
0.02704209,
0.008715294,
-0.03441957,
0.0019336654,
0.007513857,
0.009949204,
-0.016975991,
-0.030574968,
0.001995361,
0.023613123,
-0.0078320755,
0.012079321,
-0.003795894,
0.004627159,
-0.011384435,
-0.03413382,
-0.022561053,
-0.005172677,
-0.020353006
] |
There is little information about treatment outcome in patients with smear-negative pulmonary tuberculosis (PTB) or extrapulmonary tuberculosis (EPTB) treated under routine programme conditions in subsaharan Africa. A prospective study was carried out to determine treatment outcome in an unselected cohort of TB patients admitted to Zomba General Hospital, Malawi. Eight hundred and twenty-seven adult TB patients (451 men and 376 women) were registered between 1 July and 31 December 1995. Standardized treatment outcomes of treatment completion, death, default, and transfer to another district were assessed in relation to type of TB, human immunodeficiency | [
-0.019599246,
-0.01935942,
0.019679189,
-0.04740593,
0.0012974008,
0.031977016,
-0.0058957622,
-0.009586443,
-0.037866116,
-0.0007931799,
-0.0095264865,
0.026607543,
0.013177196,
0.017454121,
-0.0037406448,
0.0026514276,
0.031177592,
-0.0066652093,
-0.008147477,
-0.012284504,
-0.0000625592,
0.0059490576,
-0.011218604,
0.0017903799,
0.000042391406,
-0.007374699,
0.023822878,
-0.02571485,
-0.009619753,
-0.000026907743,
-0.004266933,
-0.0041736667,
-0.02014552,
-0.020518586,
-0.020944946,
-0.008140815,
0.0081141675,
0.0011874798,
0.028885905,
0.00673849,
0.003444191,
0.021118155,
0.002521521,
0.01762733,
0.0003512059,
0.0016854552,
0.016961142,
-0.00066993514,
-0.024422446,
0.00082149287,
0.0035740978,
-0.0030161655,
-0.012444389,
-0.0019702506,
0.0015147446,
-0.014416305,
-0.014323039,
0.0182269,
0.010325911,
-0.009946184,
-0.0045800414,
-0.006835087,
-0.04180995,
0.0130239725,
-0.03173719,
-0.0011325193,
-0.016801257,
0.0017254265,
0.002922899,
0.03485495,
0.04276926,
0.02588806,
-0.010305926,
-0.008860298,
0.031364124,
-0.020958269,
-0.00836732,
0.007821045,
-0.008933579,
0.021957552,
0.012144605,
-0.033149507,
-0.023463136,
0.0021084845,
0.022756977,
-0.0003233093,
0.0028962516,
-0.0034974862,
-0.014496247,
-0.005595978,
-0.004060415,
0.004000458,
0.016641373,
0.002797989,
-0.0050796825,
0.018373461,
-0.014496247,
0.04167671,
0.018346813,
-0.027846651,
-0.019013,
-0.0030561367,
-0.019745808,
-0.019719161,
-0.0028612767,
0.029632036,
-0.008027564,
0.00014510404,
0.014216448,
-0.017667301,
-0.0063820793,
0.051296465,
-0.0023533085,
-0.032883033,
0.016548106,
0.0013057282,
0.009293321,
-0.011078704,
-0.0050630276,
-0.01478937,
0.00666854,
-0.0023399848,
0.010952128,
-0.01532232,
0.020731766,
-0.017107705,
-0.01875985,
-0.02688734,
0.015095817,
0.003057802,
-0.012650907,
0.008946903,
0.019212857,
-0.005262884,
0.0029728631,
0.01816028,
-0.019719161,
-0.02550167,
-0.058144875,
-0.045034297,
0.014802694,
0.033495925,
0.021611134,
-0.04085064,
-0.006482008,
0.036187325,
0.03429535,
0.014203125,
-0.012431066,
0.008846975,
0.0096464,
-0.021344658,
-0.009353277,
-0.013536937,
0.0007511268,
-0.02390282,
0.009366601,
0.033709105,
-0.02053191,
-0.0052495603,
-0.037359815,
-0.003943832,
0.007714455,
-0.0064753457,
0.030031748,
0.025728175,
0.003046144,
-0.0013640196,
0.022263998,
-0.0043735234,
-0.007454642,
0.03341598,
-0.008487233,
0.009706357,
0.0048931497,
0.011591668,
-0.026794076,
0.005149632,
-0.022823596,
-0.006415389,
-0.015229054,
0.029338913,
0.0130506195,
0.009153421,
-0.027500235,
-0.01414983,
-0.004323559,
-0.004636667,
0.0065586194,
-0.009533148,
0.017001113,
0.025368433,
-0.0020118873,
0.00019871135,
-0.6540366,
-0.0023116719,
0.011265237,
0.0075279227,
0.0066418927,
-0.0019019663,
-0.000876037,
-0.0113784885,
-0.041756652,
0.009726343,
0.0130239725,
0.024702245,
0.026580894,
-0.008680427,
0.013463656,
-0.013123901,
-0.0143363625,
0.011411798,
0.010039451,
-0.012344461,
-0.012191238,
0.039038606,
0.0014048236,
0.034455236,
0.0039071916,
-0.0005966545,
0.019346096,
-0.018320166,
-0.009566457,
0.022597091,
-0.015189083,
0.025061987,
0.012331137,
0.012850763,
0.04908472,
-0.023343222,
-0.01269754,
-0.003287637,
0.007727779,
0.019532628,
-0.001457286,
0.011438445,
0.016907847,
-0.02010555,
-0.005805827,
0.034908243,
-0.0006874226,
0.007121548,
0.019879045,
-0.00015280684,
0.010932143,
0.0033126192,
-0.025341786,
0.0014323039,
0.012530994,
0.013816736,
0.014416305,
-0.0054194382,
-0.0024882115,
-0.013656851,
-0.0066119144,
-0.0060523166,
0.010472473,
-0.013643527,
-0.028965848,
0.017294236,
0.010798905,
0.02057188,
-0.010139379,
0.0010384202,
0.020225463,
0.03258991,
0.0016688006,
0.013843384,
0.023676315,
0.012504346,
-0.009832933,
-0.0011283556,
-0.030111691,
-0.004496768,
-0.00631213,
0.016801257,
0.00014541631,
0.0035774286,
0.024355827,
0.0002770925,
-0.022064142,
0.0077344407,
0.00957312,
0.028779315,
0.007847693,
0.005765856,
0.0021484557,
-0.009706357,
-0.02957874,
0.01865326,
0.016414868,
-0.013736794,
-0.0010792243,
-0.027526882,
-0.033229448,
-0.03181713,
0.028805962,
-0.0025298484,
0.022570444,
-0.006638562,
-0.019652542,
-0.009446544,
0.040264394,
-0.0073280665,
0.00051962654,
-0.014416305,
0.012750835,
-0.006148914,
0.04663315,
-0.034108818,
0.01315721,
-0.0052928627,
0.004986416,
-0.029658683,
0.019545952,
-0.00251819,
0.018400108,
-0.005539352,
0.0032992952,
0.014656133,
0.014602837,
-0.021211421,
0.0044101635,
-0.0093732625,
-0.017560711,
-0.013816736,
0.03504148,
-0.0076012034,
0.040024567,
0.001133352,
0.009260011,
-0.0052462295,
-0.018186929,
-0.031577304,
-0.018426755,
-0.004936452,
0.016894523,
0.020665146,
0.020865003,
-0.022597091,
0.0039105224,
-0.001777056,
-0.014749398,
0.0063421084,
-0.005965712,
0.0044701206,
-0.003181047,
0.00854719,
0.008946903,
-0.023383193,
-0.012464374,
-0.03408217,
-0.0028929207,
-0.014869313,
0.024595656,
0.012244533,
0.010858862,
-0.011731568,
-0.001601349,
-0.0090135215,
-0.009359939,
0.019599246,
0.019839074,
-0.026407687,
0.03067129,
-0.022717005,
0.004496768,
0.010245969,
-0.0057292157,
0.019905692,
-0.0028396256,
-0.010232645,
-0.0032776443,
0.0006911699,
-0.0018153619,
-0.00939991,
0.008687089,
0.018533345,
0.02656757,
0.01790713,
-0.0002604378,
-0.021251392,
-0.0043435446,
0.01790713,
-0.01358357,
-0.013870031,
-0.0035474503,
0.026367715,
-0.00047840615,
0.014349686,
0.02797989,
0.02582144,
0.0006653551,
0.0364538,
0.008873622,
0.009200054,
0.037253223,
0.00290791,
0.007354714,
-0.015748682,
0.011398474,
-0.020838356,
0.020278757,
0.002329992,
0.009180068,
-0.009639738,
0.003887206,
0.018453402,
-0.02127804,
0.027740061,
0.002503201,
-0.0016055127,
-0.018879764,
0.003777285,
-0.023209985,
-0.014536219,
0.0043102354,
0.01138515,
-0.015975185,
0.004933121,
0.023649668,
0.02213076,
0.017001113,
-0.007774412,
-0.00865378,
0.020598529,
0.0332028,
0.0031577304,
0.017813863,
0.011904777,
0.0061089424,
-0.015202407,
0.027313702,
0.008393967,
-0.013763441,
0.017787216,
0.01280413,
0.00290791,
-0.00553269,
0.0064886697,
0.010732287,
0.0036507093,
-0.011218604,
0.0062688277,
0.004943114,
0.012557641,
-0.027420292,
-0.011798187,
0.0010126055,
-0.022930186,
-0.0135902325,
0.0020451967,
0.049058072,
0.03461512,
0.023236632,
-0.012524332,
0.014749398,
-0.020172168,
0.037173282,
-0.012650907,
-0.0214246,
-0.007674484,
0.0153889395,
0.0038638895,
-0.0042203,
-0.014482924,
0.007987592,
-0.018173605,
0.006841749,
0.006195547,
-0.004163674,
0.0011766542,
0.023609698,
-0.0035874215,
-0.03203031,
-0.01173823,
0.020065578,
0.021318011,
-0.019212857,
-0.02319666,
-0.000026595468,
0.0049997396,
-0.03919849,
0.0029312265,
0.01195141,
-0.0037339828,
0.0002847953,
0.012077985,
-0.016934495,
-0.009319968,
0.007960944,
0.0045833723,
0.020984918,
-0.0041969833,
0.0029612049,
-0.0041769976,
-0.009273334,
-0.011758216,
0.0031460722,
-0.008493895,
-0.026207829,
-0.019972311,
-0.022570444,
-0.0022600424,
0.0033376012,
-0.015149112,
0.005912417,
0.014536219,
-0.0026864025,
0.014203125,
-0.014842665,
0.020438643,
0.022290645,
-0.041117113,
-0.011891453,
-0.018813144,
-0.017041085,
-0.007741103,
0.063687555,
0.011824834,
0.007821045,
0.013223829,
0.008507219,
0.020278757,
-0.0069949725,
-0.026287772,
0.008014239,
0.011345179,
0.0043002428,
-0.005006402,
0.019652542,
0.015455558,
0.027047226,
0.0044634584,
0.0034841625,
-0.029205674,
0.008467248,
0.005762525,
0.018853117,
-0.0023782905,
0.034775004,
0.03461512,
0.031843778,
0.009559795,
0.0013332084,
-0.0014939263,
0.019412713,
-0.010545754,
-0.01879982,
0.009872904,
-0.008160801,
0.025794793,
-0.006082295,
-0.01294403,
0.009972832,
-0.009872904,
0.0021184774,
0.014016592,
0.014216448,
0.0092200395,
0.0128441015,
0.0060489858,
0.018360136,
-0.013383714,
-0.00084772403,
0.02315669,
0.014816018,
-0.02851284,
0.045993607,
0.0014489585,
-0.012324475,
-0.018253546,
0.020225463,
-0.0007777743,
0.004273595,
0.005995691,
-0.019172886,
-0.0048931497,
-0.015948538,
-0.032643203,
0.013723469,
0.002929561,
-0.015468881,
0.0052295746,
-0.02298348,
-0.0020951608,
-0.000016030144,
0.013183857,
-0.0059357337,
-0.017867157,
-0.018786497,
0.019052973,
0.0034092162,
0.009859581,
0.015308997,
-0.014496247,
-0.006528641,
0.023889497,
-0.0065086554,
0.028726019,
0.0054194382,
-0.024702245,
0.01922618,
-0.002050193,
0.00011699924,
-0.018386785,
-0.031710543,
0.023436489,
-0.00043385485,
-0.008274053,
0.0017387503,
0.0063920724,
0.007507937,
0.0058191507,
-0.0008560514,
0.030937763,
-0.012884073,
-0.015602119,
0.005809158,
-0.021997523,
-0.0045833723,
-0.011485078,
0.0029562085,
0.0018453404,
-0.029765273,
-0.0097330045,
-0.012504346,
-0.025768146,
0.005099668,
-0.023209985,
0.0040237745,
0.012077985,
0.008034226,
0.024449093,
-0.008187449,
0.01677461,
0.0243958,
-0.00038035162,
-0.010019465,
-0.010645682,
0.027260406,
-0.0013606887,
-0.020998241,
0.0039904653,
0.012664231,
-0.034055524,
-0.035840906,
-0.016294954,
-0.0032693169,
0.014283068,
0.015295673,
0.00032247655,
-0.0568125,
-0.010026127,
-0.009959509,
-0.012597612,
-0.0023050099,
-0.015948538,
0.013210505,
-0.0020052255,
-0.020278757,
-0.015895242,
-0.0019086282,
-0.025754822,
0.00074529764,
0.018173605,
-0.012331137,
0.013696822,
-0.002131801,
0.0143363625,
0.002295017,
0.01816028,
-0.03464177,
-0.02829966,
-0.005799165,
-0.019945664,
0.026514277,
0.008613809,
0.006855073,
-0.004653322,
0.014829341,
0.03365581,
-0.0023050099,
0.013570246,
0.0069816485,
0.010952128,
-0.0073813614,
0.01777389,
0.011471755,
-0.0026231147,
-0.008513881,
0.0012657569,
0.010325911,
0.01914624,
-0.008493895,
-0.008034226,
-0.012637584,
-0.023516431,
-0.02851284,
0.0012499349,
-0.021651104,
0.014922608,
-0.040877286,
-0.018106986,
0.006115604,
0.0011375158,
-0.010932143,
-0.0029095754,
-0.0132638,
-0.0111986175,
0.0057725175,
-0.014402981,
-0.00074904494,
-0.009253349,
0.007014958,
-0.016934495,
-0.009626415,
-0.0054194382,
-0.003840573,
0.013523613,
0.002787996,
-0.0050730202,
0.00011429285,
0.0002479468,
-0.02808648,
-0.020265434,
-0.032856386,
-0.031364124,
-0.02174437,
-0.015695386,
0.0034708388,
-0.029525446,
-0.002050193,
0.003099439,
0.0007644505,
0.015988508,
-0.022317292,
-0.010112732,
0.010499121,
-0.02415597,
0.02404938,
0.008174125,
0.04567384,
0.031204239,
-0.0076345126,
-0.007894326,
-0.006082295,
-0.014056563,
0.00876037,
0.034801655,
-0.011944748,
-0.0045167534,
-0.018213576,
0.020705119,
0.029498797,
0.0009759652,
-0.013910002,
0.023449812,
-0.003365914,
-0.01879982,
-0.008200772,
-0.0001749784,
-0.032962974,
0.026327744,
-0.014269744,
-0.0053994525,
-0.0061688996,
-0.019732485,
-0.009819609,
0.015961861,
-0.03418876,
0.024622303,
-0.008094182,
-0.018466728,
-0.00074904494,
0.0018919734,
-0.025661556,
0.013963297,
-0.015762005,
0.012684217,
0.00029208174,
0.0023349884,
0.024036057,
-0.005975705,
-0.011831496,
0.0081141675,
-0.008553852,
0.040237747,
-0.018067013,
-0.0078810025,
0.015202407,
0.0018136963,
-0.0042935805,
-0.021024888,
0.005146301,
-0.031204239,
-0.016401544,
-0.001548054,
0.011931424,
0.031577304,
-0.021051535,
-0.026061269,
-0.012404418,
-0.0062288563,
0.009832933,
-0.036720272,
0.013750117,
-0.027686767,
-0.016641373,
-0.017360855,
0.012564302,
0.029738626,
0.0017370848,
0.018426755,
-0.0054061143,
0.019905692,
-0.01801372,
0.0050130635,
0.022117436,
-0.008067535,
-0.022583768,
-0.007241462,
-0.031977016,
-0.016588077,
-0.007174843,
-0.0028063164,
-0.003993796,
-0.0134370085,
-0.014842665,
0.009453205,
-0.0049697612,
-0.026434334,
0.024569008,
0.004013782,
0.009093464,
-0.019239506,
-0.00039138537,
0.029312266,
0.0009559796,
0.01404324,
-0.0012299493,
-0.022530474,
0.0039071916,
0.010379206,
0.033282746,
0.0056526037,
-0.05457411,
-0.0022050817,
0.0031277519,
0.049670964,
-0.0040837317,
-0.0042036455,
-0.0066452236,
-0.013150548,
-0.0037706231,
0.0024848806,
-0.008360658,
0.005592647,
0.010798905,
-0.017160999,
-0.010312588,
-0.0032126908,
-0.03021828,
-0.0069283536,
0.027473588,
0.0003484995,
-0.027193788,
-0.01021266,
-0.012810792,
0.046686444,
-0.0032193528,
-0.0032260146,
-0.0056692585,
-0.0027846652,
-0.053854626,
0.0055093733,
-0.019919017,
0.022477178,
0.0043002428,
0.0068817204,
-0.0009026845,
0.0036440475,
0.012850763,
0.003096108,
-0.028726019,
-0.034775004,
-0.0013790089,
-0.011438445,
0.03075123,
0.0017137682,
-0.060489856,
0.0077877357,
0.028486192,
-0.0128174545,
-0.01088551,
0.01489596,
-0.0060056834,
-0.0043135663,
0.0026830717,
0.0022783624,
-0.019852398,
-0.0227703,
0.009839594,
-0.021211421,
-0.0028879242,
0.00613559,
0.0036373856,
-0.00009513995,
-0.021691076,
0.04042428,
0.012850763,
0.00060331635,
-0.003880544,
-0.021517867,
-0.009832933,
-0.024129324,
0.0068750586,
0.025035338,
0.0039904653,
-0.009812947,
-0.015482206,
0.012371108,
-0.01521573,
0.024569008,
-0.006398734,
-0.025088634,
0.018426755,
-0.011758216,
-0.005006402,
0.0017937107,
-0.008500556,
0.017240942,
-0.0063387775,
-0.012797468,
-0.017360855,
-0.0013332084,
0.019426037,
0.011451769,
-0.027713414,
0.0014547877,
-0.010192674,
-0.017720597,
-0.0057758484,
-0.016747963,
0.012364446,
-0.028219717,
0.012757497,
-0.029445503,
-0.014509571,
-0.006688526,
0.005046373,
-0.01457619,
-0.004266933,
0.028965848,
0.1777922,
-0.010585725,
-0.0013573577,
-0.0012924044,
0.006198878,
0.020185491,
0.012770821,
-0.009146759,
-0.00032726477,
0.012137943,
0.0030261583,
-0.009872904,
-0.0044567967,
0.011938086,
-0.00766116,
0.00052587205,
-0.03794606,
-0.010019465,
0.007854355,
0.0043069045,
-0.012737512,
0.001727092,
0.0072081527,
0.0073613757,
0.018080339,
0.0054527475,
-0.014083211,
0.0032643205,
0.019026324,
-0.004380185,
-0.0046399985,
-0.0203587,
0.0058724456,
-0.0014314711,
-0.011758216,
-0.009273334,
0.00037972708,
-0.021464573,
-0.004773236,
0.018693231,
-0.0014989227,
0.026447657,
-0.007940959,
-0.020611852,
-0.009653062,
0.020518586,
0.0022866898,
-0.00096513965,
-0.014869313,
-0.015988508,
-0.019132914,
-0.024702245,
0.015175759,
-0.0067784614,
-0.025022015,
-0.0011566686,
0.025754822,
0.005046373,
-0.013450333,
0.009859581,
0.0005479395,
-0.004370192,
-0.021198098,
0.024768865,
-0.006868397,
0.03341598,
-0.009639738,
0.0022433875,
0.0053028553,
-0.008647118,
0.015668739,
-0.008000916,
-0.0017046081,
-0.0017354194,
-0.015682062,
-0.029418856,
0.021437924,
0.022370588,
0.027500235,
0.019559275,
-0.0047499193,
-0.017574035,
-0.029552093,
0.018280195,
-0.034695063,
-0.026834046,
0.0065119863,
0.017054409,
0.00014250174,
0.0110187465,
-0.00057083974,
0.008747047,
-0.013643527,
0.004666646,
0.03967815,
0.010312588,
0.0022850244,
-0.001893639,
-0.008020902,
-0.016081775,
-0.008720399,
0.06955001,
-0.008906932,
0.009846256,
0.00631213,
-0.006618576,
-0.00645536,
0.018413432,
0.011371827,
-0.0018503368,
0.026834046,
-0.032350082,
0.0030861152,
-0.02025211,
0.020771736,
0.020385347,
0.017280912,
-0.008727061,
0.006868397,
-0.013643527,
0.0062555037,
-0.038105946,
-0.00876037,
0.026834046,
-0.03418876,
-0.020025607,
-0.010132717,
0.007574556,
0.006515317,
-0.023583049,
-0.007494613,
-0.02404938,
-0.008040887,
-0.016468164,
0.0024332511,
0.011784863,
-0.0053961216,
-0.01074561,
-0.016414868,
0.012744173,
0.019958988,
0.0007969272,
0.0016987791,
0.009879566,
-0.008287377,
-0.023130042,
0.023996087,
0.004323559,
0.011118676,
-0.01227118,
-0.008953565,
-0.03053805,
-0.0039604865,
-0.0192928,
0.043355506,
-0.016894523,
-0.011551697,
-0.024302533,
-0.0268074,
0.009046831,
-0.022810271,
-0.00865378,
0.041516826,
-0.020585204,
0.0005162956,
0.029871862,
-0.16894524,
0.0182269,
0.008593823,
0.007994254,
0.041969836,
-0.0020968262,
-0.000945154,
-0.00027813343,
-0.014922608,
0.007494613,
0.018520022,
0.013530275,
-0.030351518,
0.0066319,
-0.014882636,
0.004103717,
-0.0066785333,
0.015615443,
0.04436811,
0.00038513984,
0.02174437,
-0.011744891,
0.012784145,
-0.0027513558,
0.007001634,
0.020518586,
-0.013317095,
0.0035507812,
0.0032210182,
-0.024915425,
-0.01404324,
0.011864806,
0.031044353,
0.005053035,
-0.01478937,
0.0034142127,
0.010405854,
-0.028592782,
-0.007354714,
0.008673766,
0.030964412,
0.028139774,
0.0038738823,
-0.003089446,
-0.011704921,
0.018400108,
0.026327744,
0.0048298617,
0.017880483,
0.013536937,
-0.0030877807,
-0.014522895,
0.006188885,
-0.013310433,
-0.004869833,
-0.004200314,
-0.00702162,
0.0026930643,
0.009899551,
0.001246604,
-0.021411277,
-0.03064464,
0.018480051,
0.0076012034,
-0.0048098764,
-0.04735263,
-0.0042436165,
-0.011678273,
-0.009699695,
0.011218604,
-0.01833349,
-0.012284504,
0.0014922607,
-0.018719878,
0.03173719,
0.009233364,
-0.018093662,
-0.003890537,
-0.013350405,
-0.008800342,
-0.013450333,
0.015788652,
0.00004135049,
0.025115281,
0.021051535,
0.03711999,
0.008960227,
0.027633471,
0.0063820793,
-0.02695396,
-0.0012549313,
-0.008727061,
0.0026397693,
-0.011298546,
0.023289926,
0.03762629,
-0.030964412,
-0.017134352,
0.005536021,
-0.012391094,
-0.00080525456,
-0.008060873,
-0.026127888,
0.008633794,
0.040024567,
0.0044101635,
-0.0052928627,
0.013363728,
0.047112804,
0.008014239,
-0.022410559,
0.002295017,
0.0025648233,
0.016001832,
0.015255702,
0.030298224,
0.0031061007,
-0.014602837,
0.019719161,
-0.01950598,
0.041836597,
-0.0065586194,
-0.016574753,
0.025008691,
-0.017160999,
-0.0206385,
-0.11533044,
0.006025669,
0.008287377,
-0.0043601994,
0.0046100197,
0.013117239,
-0.009706357,
0.006198878,
0.0014156492,
0.017347531,
-0.011125337,
-0.015548824,
0.009999479,
-0.015202407,
0.04450135,
-0.014376334,
0.018106986,
-0.012564302,
-0.021357981,
0.031790484,
-0.022503825,
-0.006465353,
-0.004836524,
-0.0047765668,
0.014482924,
-0.011358502,
-0.012737512,
0.032056957,
-0.0029628705,
-0.00021109828,
0.0110187465,
-0.018306842,
0.014456276,
-0.010652344,
-0.008820327,
0.004276926,
-0.033495925,
-0.014842665,
0.037972707,
-0.013989945,
-0.008500556,
0.012850763,
0.025328461,
-0.0024399129,
0.022370588,
-0.02166443,
-0.037386462,
0.0049597686,
0.020904975,
-0.008800342,
-0.0106590055,
-0.034055524,
-0.019625895,
0.0020768405,
-0.0042236308,
-0.012471036,
0.001180818,
0.027393645,
0.0072081527,
0.014709428,
0.0043935087,
0.011458431,
0.019372743,
0.033815693,
-0.0014439621,
-0.02315669,
0.001990236,
-0.017680624,
0.0031977016,
-0.030564697,
-0.013043958,
-0.020891652,
-0.015455558,
-0.008906932,
-0.04231625,
0.009233364,
-0.034055524,
-0.017653977,
0.0053295027,
-0.033602513,
-0.020092225,
0.012990663,
0.010539092,
-0.0030694604,
0.033495925,
0.025101958,
0.027047226,
-0.025022015,
-0.0005812489,
0.002308341,
0.0084472615,
0.01875985,
-0.024462417,
-0.023769582,
0.025834765,
0.025808116,
-0.025168577,
-0.041117113,
0.0048631714,
0.022144085,
-0.02177102,
-0.021264715,
-0.067045145,
0.008660442,
0.025754822,
-0.008613809,
0.0033076226,
0.021091508,
0.026660837,
0.016268307,
0.0048298617,
0.007721117,
-0.027606824,
0.033096213,
-0.022343941,
-0.009599767,
-0.010439163,
0.019945664,
-0.0057325466,
-0.008673766,
0.022410559,
0.01950598,
-0.0020468622,
0.009366601,
0.01294403,
0.04159677,
-0.019026324,
-0.008693751,
-0.014229773,
0.016747963,
-0.0014214783,
0.0001762275,
0.014602837,
-0.016548106,
-0.018666584,
-0.0016896189,
0.0057292157,
0.0023199993,
0.021757696,
0.0053394954,
0.018733202,
0.027606824,
-0.022503825,
-0.024022734,
0.0052295746,
-0.022050818,
-0.007947621,
0.014096535,
-0.0036540404,
0.037866116,
-0.00734139,
-0.0068617347,
0.0031977016,
-0.0048498474,
-0.009200054,
-0.028912552,
-0.019439362,
0.014163153,
-0.0007348885,
-0.00450343,
-0.0011533377,
-0.0041336957,
0.044128284,
0.014722751,
0.002496539,
0.022463854,
0.0044767824,
-0.008607147,
0.005679251,
-0.006472015,
-0.010532429,
-0.022477178,
0.011478417,
-0.012750835,
-0.012724188,
0.03312286,
0.005053035,
0.0013798416,
-0.00014468767,
0.02404938,
-0.0023449813,
0.008527204,
-0.0024249237,
0.004839855,
-0.026114564,
0.006185554,
0.022743654,
0.006462022,
-0.015042521,
0.022850243,
-0.02415597,
0.009140098,
-0.017387502,
0.031017706,
-0.02031873,
0.0057258843,
-0.0033709104,
0.026381038,
0.03280309,
-0.0025165246,
-0.00079359626,
0.035334602,
-0.00008832193,
0.0068617347,
-0.0034974862,
-0.030617993,
-0.0052362364,
0.0011908108,
-0.031550657,
-0.030591346,
-0.026114564,
0.013963297,
0.020944946,
0.015655415,
-0.0074346564,
-0.011311869,
-0.017280912,
-0.0036940116,
-0.003670695,
-0.0033226118,
-0.021837637,
0.01031925,
-0.002794658,
0.03131083,
0.0007960945,
-0.014109858,
0.006581936,
-0.015575471,
0.003460846,
-0.03141742,
0.024475742,
-0.02400941,
-0.005392791,
-0.0021617794,
-0.039598204,
-0.025954679,
0.017001113,
0.0057358774,
0.03173719,
0.0050830133,
0.0107123,
0.061395872,
0.023556402,
-0.017374178,
0.019998958,
0.003610738,
-0.0073014186,
0.010345898,
0.013350405,
-0.006835087,
-0.051616233,
-0.0111986175,
-0.0080875205,
0.015455558,
-0.040557515,
-0.031710543,
0.023303252,
-0.016614724,
-0.00083606574,
-0.0045167534,
0.00939991,
0.021211421,
-0.014709428,
0.017294236,
-0.007781074,
-0.03131083,
-0.0005171283,
0.025195224,
0.023503108,
-0.0015730361,
-0.025061987,
-0.012071324,
-0.012557641,
-0.02294351,
-0.023583049,
0.0104791345,
-0.02702058,
-0.017787216,
-0.013723469,
0.013310433,
-0.018480051,
0.010225983,
-0.006202209,
-0.018200252,
-0.017707273,
-0.007774412,
-0.047379278,
0.0039271773,
-0.0040337676,
-0.028219717
] |
CONTEXT Gallstone disease is a leading cause of morbidity in western countries and carries a high economic burden. Statins decrease hepatic cholesterol biosynthesis and may therefore lower the risk of cholesterol gallstones by reducing the cholesterol concentration in the bile. Data on this association in humans are scarce. OBJECTIVE To study the association between the use of statins, fibrates, or other lipid-lowering agents and the risk of incident gallstone disease followed by cholecystectomy. DESIGN, SETTING, AND PARTICIPANTS Case-control analysis using the UK-based General Practice Research Database. Incident patients between 1994 and 2008 and 4 | [
-0.005665496,
0.007521434,
0.04120834,
-0.03091928,
-0.030554606,
0.026230594,
-0.020513002,
0.021997754,
-0.017387211,
0.0005706196,
-0.0022629423,
0.028314454,
0.0015401032,
0.011910565,
0.017960273,
0.030294122,
0.047329683,
-0.012262217,
0.024771892,
0.0076907477,
-0.0060399394,
0.020838605,
0.008374514,
-0.001116819,
-0.0021033967,
-0.0032137036,
0.017803984,
-0.02735067,
-0.02173727,
0.0032918483,
0.0036272197,
-0.0030313658,
-0.007957743,
-0.00709815,
-0.011532865,
-0.003562099,
0.014678192,
-0.0039039825,
-0.005378965,
-0.013141345,
0.017374188,
-0.010875147,
0.013050176,
0.015954558,
0.014092107,
0.023586696,
0.013427876,
0.0042295856,
-0.04779855,
0.016514596,
0.009859265,
0.018637527,
-0.008993161,
-0.0037672292,
0.0072935116,
0.004490068,
-0.016267136,
-0.00011141735,
-0.002253174,
-0.02066929,
-0.009885313,
-0.0041514407,
-0.01927571,
-0.0019112908,
-0.008068448,
0.016071774,
-0.017009512,
0.028627034,
-0.00094424933,
0.031179763,
0.025110519,
0.029408481,
0.007313048,
0.009865778,
0.020968847,
-0.0079903025,
-0.02413371,
-0.024902133,
-0.003763973,
0.027559055,
0.029538723,
0.0016605763,
0.0060106353,
0.04126044,
0.025019351,
-0.011493794,
-0.0011990338,
0.023860203,
-0.007176295,
-0.008569877,
-0.0066618416,
0.025253784,
-0.002419232,
0.013414852,
0.013883721,
0.025566364,
-0.011428673,
0.009299228,
-0.0037965334,
0.00039682892,
0.003855142,
-0.00078673876,
-0.035634015,
-0.011858469,
-0.022349404,
0.013050176,
-0.01614992,
-0.005297564,
0.000085318214,
-0.010816539,
-0.015824316,
0.04391736,
0.0007220251,
-0.01614992,
0.02053905,
-0.027402766,
0.008341954,
-0.005307332,
0.01561593,
-0.027506959,
0.0014155599,
-0.011539377,
0.034279507,
0.006179949,
0.0073846807,
-0.0036207077,
-0.05543069,
-0.0026145938,
0.005763177,
0.0058380654,
0.015824316,
-0.0016133639,
0.00037932774,
0.0136883585,
-0.023547623,
0.0017826776,
-0.015928509,
-0.00084087026,
-0.02034369,
-0.027845586,
-0.011135629,
0.017517453,
0.005382221,
0.0069744205,
-0.01956224,
0.039697543,
0.023182949,
0.027845586,
-0.027012043,
-0.013675335,
-0.0026666904,
-0.011194238,
-0.0033732492,
0.003055786,
-0.0035165146,
0.009221083,
0.00025905806,
0.023573672,
-0.012027782,
-0.011402625,
0.0032999886,
0.0050045215,
0.0004892188,
0.002440396,
0.024745844,
0.010386743,
0.00403748,
0.0077884286,
-0.00026719813,
-0.0008587785,
0.00016137709,
0.022518719,
-0.026009183,
0.017348139,
0.005984587,
0.028887516,
-0.023547623,
0.018754745,
-0.0026243618,
-0.027741393,
-0.055534884,
0.007306536,
0.03258637,
-0.00829637,
-0.040400848,
-0.0029597331,
0.029226145,
0.009631343,
0.012646428,
-0.026009183,
-0.009097354,
0.023300165,
0.00018101503,
-0.012906911,
-0.64599675,
-0.013883721,
0.015863389,
-0.0026845986,
0.023964396,
0.032690562,
0.01277667,
0.014691217,
-0.0118389325,
0.019510144,
-0.0015433592,
0.036233123,
0.033211526,
-0.014743313,
-0.01612387,
-0.015329399,
-0.019288734,
-0.0036858283,
0.005401757,
-0.018220756,
-0.02637386,
0.027142283,
-0.009833217,
0.015655002,
0.027220428,
0.01854636,
0.026504101,
-0.017908176,
0.010562568,
0.036545705,
-0.011558914,
0.04001012,
0.005479902,
0.018350996,
0.04068738,
-0.011552402,
0.008127056,
0.018220756,
0.02779349,
0.023430407,
-0.022896418,
-0.018950107,
0.011265871,
-0.0020871165,
-0.019770626,
0.014717265,
0.026699463,
0.015759196,
-0.020044133,
0.013193442,
0.0036402438,
0.008315906,
-0.0059259785,
-0.0064339195,
0.013180418,
0.0064762477,
0.021776343,
-0.036102884,
0.00060521497,
0.021190256,
-0.009182011,
-0.008205201,
-0.021815415,
-0.00006827492,
-0.032794755,
0.013584166,
-0.01050396,
0.009872289,
0.00049206783,
-0.010276037,
0.008674069,
0.018390069,
-0.009891826,
-0.014092107,
0.051132727,
0.011480769,
0.012366409,
0.031466294,
-0.04305777,
0.00007397298,
0.017087657,
0.016319232,
-0.022206139,
-0.0064208955,
0.009514126,
0.02564451,
-0.0005278842,
-0.0022873625,
0.0071307104,
-0.01934083,
0.004073296,
0.013753479,
-0.011480769,
-0.012118951,
0.0013015989,
0.022505693,
0.0018119819,
0.0032120757,
0.010393254,
-0.00056247954,
-0.03628522,
0.013388804,
-0.008732678,
0.025891967,
0.016332258,
0.014157227,
-0.028913565,
-0.0059031863,
0.019067325,
-0.050403375,
0.010673273,
0.012438042,
-0.0061669247,
-0.010647225,
0.00908433,
-0.020851629,
0.007834014,
-0.008042399,
-0.0077754045,
-0.033211526,
0.025253784,
-0.009435981,
0.010432327,
0.015928509,
-0.00003495147,
0.026985994,
-0.0041091125,
-0.0077363322,
-0.0031029985,
-0.009735536,
0.027272524,
0.013857673,
0.045480255,
0.0071176863,
0.021633077,
0.0021717735,
0.0128548145,
0.012561772,
-0.00709815,
-0.050846197,
-0.018468214,
-0.011109581,
0.020708364,
-0.006681378,
-0.010080676,
-0.018116562,
0.0040049194,
0.011461233,
-0.004187257,
-0.0023801595,
0.007827501,
-0.0022889907,
-0.00053154724,
0.033524107,
0.0078665735,
0.011461233,
0.017699791,
-0.027142283,
0.0007533644,
0.0029597331,
0.01807749,
-0.002961361,
-0.0035100025,
0.0034123217,
-0.024316048,
-0.028184215,
0.015811292,
-0.016319232,
-0.014821458,
-0.01508194,
0.016110847,
-0.007703772,
0.020265544,
0.01359719,
-0.01104446,
0.02732462,
0.0060334275,
-0.008048912,
-0.006284142,
-0.00076476054,
0.007013493,
-0.016188992,
-0.015524761,
0.005877138,
0.03745739,
0.005909698,
0.023769034,
-0.0051217386,
-0.012529211,
0.015003796,
-0.0017517452,
0.010588616,
-0.008237761,
-0.010640712,
-0.006525088,
0.0015783615,
0.016084798,
-0.0028783323,
0.003656524,
0.0154726645,
0.046209607,
0.0075865546,
0.030450411,
-0.027845586,
0.02630874,
-0.027897682,
0.015290326,
-0.0023882994,
0.013649287,
0.0032088195,
0.008042399,
-0.013265074,
-0.013857673,
-0.025631484,
0.010477912,
0.0006601605,
0.007137222,
-0.039619397,
-0.0017989577,
-0.0055189743,
0.0054375734,
0.007111174,
0.019405952,
-0.0007191761,
-0.014639121,
0.022531742,
-0.0008449403,
0.015212182,
-0.018715672,
-0.009833217,
-0.011943126,
0.0025983136,
-0.0049100965,
0.020773485,
0.0061180843,
0.014469806,
-0.014912627,
-0.0067464984,
0.024329072,
-0.008967113,
0.0038746782,
-0.005870626,
0.024941206,
0.008029375,
0.0035295389,
0.0052584917,
0.018911034,
0.0144567825,
-0.008094496,
0.014613072,
0.0091299135,
0.015042868,
-0.03196121,
0.002017112,
0.012509676,
-0.021372594,
0.0015107989,
0.010582104,
0.033211526,
0.0031730032,
0.033498056,
-0.0007582485,
0.0031225348,
0.010399766,
-0.0054082694,
0.011526354,
-0.00754097,
0.019913891,
-0.010451863,
-0.018272853,
-0.028158166,
-0.013349731,
0.02069534,
-0.027767442,
0.007339096,
0.008869431,
0.027402766,
-0.0012552004,
0.015655002,
0.012633405,
-0.009364348,
-0.042823333,
-0.008478708,
-0.0047928793,
0.0042328415,
-0.014053035,
-0.016657861,
0.013558118,
-0.00047375268,
0.023769034,
-0.0017517452,
0.005333381,
0.020617194,
-0.0069548846,
-0.01056908,
-0.013147858,
0.03253427,
-0.01672298,
0.021984728,
-0.014587023,
-0.01337578,
-0.007501898,
-0.00066260254,
-0.015485688,
0.021698197,
0.00978112,
-0.0038388618,
-0.003343945,
0.009709488,
-0.0026878545,
-0.00022446271,
0.0099308975,
0.007430265,
0.012535724,
0.008628485,
0.019783651,
-0.01949712,
0.007013493,
0.038629565,
-0.021463763,
0.011467745,
-0.046235655,
-0.008973625,
-0.024928182,
0.025683582,
0.0025983136,
0.009136426,
0.00046113555,
0.025761725,
0.02000506,
0.015420568,
-0.03047646,
-0.0063525187,
0.021216305,
0.005782713,
0.012503163,
-0.0034709303,
0.0034318578,
-0.003770485,
0.030867184,
-0.022323355,
-0.03693643,
0.013258562,
-0.02000506,
-0.0026992506,
-0.01719185,
0.02987735,
0.030658798,
0.0109467795,
-0.029851303,
0.0054473416,
0.045037437,
-0.010790491,
-0.013121809,
-0.01211244,
-0.009709488,
-0.020200424,
0.0087912865,
-0.00996997,
-0.0026585502,
0.00086610456,
-0.016736005,
-0.0007716796,
-0.0045161163,
0.0073325844,
-0.0041026003,
0.009963458,
0.01892406,
0.01845519,
-0.0042458656,
0.00608878,
0.02628269,
0.015498713,
-0.017699791,
0.013336708,
0.020122278,
0.001015068,
0.00016473487,
0.0012454323,
-0.030841136,
0.0068116193,
-0.0009629715,
0.013082737,
-0.013069713,
-0.013870697,
-0.0037769973,
0.011057485,
-0.005909698,
0.009331788,
-0.0060529634,
-0.040557135,
-0.036832236,
-0.0039039825,
0.0084526595,
0.009663903,
-0.02486306,
-0.010634201,
-0.008205201,
-0.011005389,
0.0030053176,
-0.0047277585,
-0.01366231,
0.0135320695,
0.029408481,
-0.013896745,
0.009162474,
0.00262599,
-0.025566364,
0.02167215,
-0.019106396,
-0.014469806,
-0.004871024,
-0.00011050159,
0.016097823,
0.014053035,
-0.0074498015,
0.025110519,
-0.024719795,
-0.010074163,
-0.030867184,
0.01473029,
-0.020942798,
-0.0072674635,
-0.013766504,
-0.01820773,
-0.012652941,
-0.0004346803,
-0.027611151,
-0.0016483662,
0.013453924,
-0.003334177,
-0.009292715,
0.0006931278,
-0.006108316,
-0.005105458,
-0.01621504,
-0.017426284,
-0.020044133,
0.015094965,
0.026907848,
-0.009182011,
0.02867913,
0.006525088,
0.0021782855,
0.0093448125,
0.0047798553,
0.010679785,
-0.0042426097,
-0.021346547,
-0.0004668336,
0.0042719143,
-0.0151340375,
-0.04858,
-0.002945081,
-0.010373718,
0.019366879,
0.0018494262,
-0.009924386,
-0.03797836,
0.0044965805,
0.009403421,
-0.0063720546,
-0.033211526,
-0.025045399,
-0.00074034027,
0.0067595225,
-0.020057157,
-0.028262358,
0.021971704,
-0.03123186,
0.010803514,
-0.022518719,
-0.013206466,
0.0049914974,
0.008608948,
-0.010184868,
-0.038290936,
-0.008661046,
-0.008888967,
-0.023925323,
-0.020786509,
-0.014157227,
0.024394192,
0.025058422,
0.033393864,
-0.01221012,
0.015550809,
-0.005548279,
0.0053008203,
-0.003153467,
-0.0077754045,
-0.0011925218,
-0.0042719143,
0.023990445,
0.010263013,
-0.01652762,
0.02448536,
-0.023873227,
0.01681415,
-0.00024623744,
0.0019878077,
-0.0010875147,
-0.020330664,
-0.02488911,
-0.012262217,
-0.012959008,
0.003363481,
-0.0009556454,
-0.04363083,
-0.025983136,
-0.010751418,
-0.01154589,
0.010985852,
-0.0043793633,
0.02442024,
-0.031883065,
0.021398643,
0.0014383522,
-0.017374188,
-0.0064208955,
-0.024459314,
0.0005466064,
0.007111174,
-0.013844648,
-0.007111174,
0.023886252,
-0.0047147344,
-0.025826847,
-0.0078665735,
0.015003796,
-0.03258637,
0.023235045,
0.022753153,
-0.01898918,
-0.005463622,
-0.02009623,
0.028809372,
-0.0153814955,
-0.023143876,
0.012268729,
-0.025826847,
0.0029727572,
-0.018324949,
-0.0062385574,
-0.009637855,
-0.03253427,
0.005965051,
-0.025514267,
0.04079157,
0.020799533,
0.005144531,
-0.016097823,
0.011506817,
0.007938206,
-0.006407871,
0.036571752,
0.030085737,
0.010432327,
-0.015707098,
-0.02173727,
0.03154444,
-0.020591147,
-0.01883289,
0.013258562,
0.021229329,
-0.013121809,
-0.009585759,
0.00013420958,
-0.027298573,
-0.0049524247,
-0.004558445,
0.0037021085,
-0.011317967,
-0.014443758,
-0.0021506092,
0.012314313,
-0.042354465,
0.0145479515,
-0.033550154,
-0.012477115,
0.0000032035666,
-0.012678989,
0.0017045328,
0.013304147,
-0.001422886,
0.02306573,
-0.0057306164,
-0.012444555,
0.0079903025,
0.013108785,
0.01962736,
-0.02047393,
-0.01091422,
0.03839513,
0.0017517452,
-0.019783651,
0.033836685,
0.014756338,
0.020812556,
-0.03375854,
0.0072479276,
-0.026269667,
-0.022531742,
0.012750622,
0.020434856,
-0.004187257,
-0.016918343,
0.016631812,
-0.016866246,
-0.008244273,
-0.028418647,
-0.020083206,
0.03480047,
-0.022701055,
-0.008368002,
-0.01956224,
-0.0047928793,
-0.0057696886,
0.0017533733,
0.00085959246,
-0.008420099,
0.021398643,
-0.022101946,
0.016801126,
0.01053652,
0.018324949,
-0.021502836,
0.008387539,
-0.013453924,
-0.015785243,
0.006508808,
-0.0046072854,
-0.028288407,
-0.043969456,
-0.011584962,
-0.007814477,
0.01359719,
-0.0062092533,
0.038186744,
0.013030641,
-0.002528309,
0.0063427505,
-0.00996997,
0.008302881,
-0.010432327,
0.018442165,
0.007339096,
0.0010354182,
0.0011648454,
-0.010217428,
0.0145479515,
-0.001023208,
-0.012932959,
-0.01650157,
-0.02066929,
0.02104699,
-0.02590499,
-0.0052161636,
-0.0077493563,
-0.017699791,
-0.007423753,
-0.0051412745,
0.009917874,
-0.020434856,
-0.0023052706,
-0.022570815,
0.026386883,
-0.005108714,
-0.0042002816,
-0.017139753,
-0.02526681,
0.0028799605,
-0.020526025,
0.020786509,
-0.009442493,
0.042328417,
-0.014118155,
-0.012985056,
0.0051217386,
0.007195831,
-0.01605875,
-0.0017077888,
-0.01012626,
0.002430628,
-0.0025104007,
0.02488911,
-0.015954558,
0.011330992,
-0.00914945,
-0.006349263,
-0.0224015,
-0.010523495,
-0.004252378,
-0.024237903,
0.036962476,
0.0021734014,
-0.022883393,
-0.008563364,
0.036207076,
-0.016696932,
-0.007606091,
0.004089576,
-0.0017826776,
0.012092903,
-0.023638792,
-0.0058087613,
-0.001008556,
-0.011116094,
0.01123331,
-0.042640995,
0.0019536193,
0.005577583,
0.0044119237,
-0.021932632,
-0.006798595,
-0.023391334,
-0.017777935,
-0.01280923,
-0.0061441325,
-0.02211497,
0.0019617593,
0.008849896,
-0.006883252,
-0.0035914034,
0.0007847037,
0.0113765765,
0.021411667,
-0.020552075,
0.0051412745,
0.0055678147,
0.020643244,
-0.020591147,
-0.0108230505,
-0.0033065006,
-0.00013889011,
0.0072804876,
-0.017517453,
-0.016462497,
-0.0062450697,
-0.002246662,
0.015277303,
-0.035034906,
0.034878615,
0.0019698995,
0.0015344052,
-0.010777466,
-0.0098071685,
-0.038343035,
0.012053831,
-0.036259174,
-0.0017045328,
-0.04006222,
-0.011383088,
0.01568105,
-0.007287,
0.0052063954,
0.012509676,
-0.027168332,
-0.0045291404,
0.02173727,
0.17691976,
-0.032742657,
0.001317065,
0.027376717,
-0.00004141266,
0.0021147928,
0.033888783,
0.009787632,
-0.021580981,
0.028340504,
0.020682316,
-0.0006149831,
-0.015290326,
-0.00089703687,
0.015707098,
-0.015225206,
-0.03107557,
-0.008133568,
0.016918343,
0.016866246,
0.01192359,
-0.00870663,
-0.004861256,
-0.016019678,
0.029486626,
-0.004861256,
-0.0011786836,
0.024550483,
0.031466294,
0.0020675804,
0.0052617476,
-0.004691942,
0.004678918,
0.005707824,
0.0014570743,
-0.0046463576,
-0.015993629,
0.0072283912,
0.007072102,
-0.009924386,
-0.007501898,
0.011487281,
-0.037014574,
-0.0068246434,
-0.009702976,
0.008302881,
0.002134329,
-0.009064794,
-0.0074498015,
0.010523495,
-0.038863998,
-0.010647225,
0.02091675,
0.016566692,
-0.019575264,
-0.020057157,
-0.0074367775,
0.02732462,
0.0040570158,
-0.0001312588,
0.02599616,
0.0070590777,
-0.00010510878,
0.014157227,
-0.026907848,
0.025579387,
-0.011806373,
-0.023573672,
-0.006508808,
0.0031713753,
0.028158166,
-0.0017077888,
-0.015967581,
-0.011383088,
0.0019015227,
-0.02382113,
0.005776201,
-0.0006007379,
0.0005376523,
0.028887516,
-0.008368002,
-0.012320826,
-0.031857017,
0.020109255,
-0.02113816,
-0.030867184,
0.018064465,
0.013675335,
-0.023573672,
0.019445024,
-0.013649287,
0.017960273,
-0.007619115,
-0.008433123,
0.031570487,
-0.0031599791,
-0.0023655074,
-0.009240619,
-0.0044347155,
-0.013304147,
-0.014274444,
0.07751961,
-0.028132116,
0.030606702,
-0.0041058566,
-0.0022596864,
-0.065537415,
0.0018152379,
-0.006980933,
0.026022209,
0.0067660348,
-0.028001877,
0.006124596,
-0.010582104,
-0.0065576485,
0.027559055,
0.035165146,
-0.0047538066,
0.0022157298,
-0.017361162,
-0.01508194,
-0.008237761,
0.0009768096,
0.011129118,
0.015055892,
-0.022987587,
-0.014079083,
-0.033367816,
-0.000095747695,
-0.024172783,
-0.0125487475,
-0.025371002,
-0.0035230268,
-0.019223614,
-0.01015882,
0.033498056,
0.007710284,
-0.00877175,
-0.0060725,
0.02034369,
-0.004079808,
0.0028229798,
0.0020822326,
-0.0154726645,
0.03542563,
-0.018429141,
0.0051184823,
-0.0008547084,
-0.033732492,
-0.0049524247,
-0.011148654,
0.00245342,
0.0071567586,
0.006896276,
0.023261093,
-0.00949459,
-0.014521903,
-0.036545705,
-0.01050396,
0.010588616,
-0.02593104,
-0.0015930136,
0.05423247,
0.012405482,
0.021489812,
0.011291919,
-0.16274951,
0.02337831,
0.011825909,
-0.00224015,
0.035503775,
0.0036955965,
-0.0046040295,
0.0053431485,
0.003262544,
-0.024185807,
0.018976156,
-0.0014261421,
-0.025579387,
-0.025019351,
-0.00051567407,
0.0075670187,
-0.002739951,
0.01823378,
0.024693748,
0.015160086,
0.036076836,
-0.027819538,
0.0017322091,
-0.025957087,
0.023274118,
0.031935163,
-0.019197565,
0.028653082,
-0.023873227,
0.006616257,
-0.011083533,
-0.0003058635,
0.015707098,
-0.001929199,
-0.0105755925,
0.017999345,
0.000016547257,
-0.024602579,
-0.01956224,
0.029356385,
0.01568105,
0.04584493,
-0.0085438285,
-0.00754097,
-0.0016052239,
-0.00826381,
0.017556526,
-0.01779096,
0.052044418,
-0.0029890374,
0.0055417665,
0.0010769326,
0.005186859,
0.011597986,
0.0071502463,
0.04798089,
0.0030769503,
0.012750622,
-0.0041384166,
0.01097934,
-0.011910565,
-0.022831297,
0.018064465,
0.022193115,
0.01034767,
-0.022974562,
-0.0175435,
-0.015342423,
-0.012262217,
0.020369736,
-0.013199954,
0.0022613143,
0.0015913857,
-0.010386743,
0.029981544,
0.0074693374,
-0.005470134,
-0.00877175,
-0.007807965,
-0.00949459,
-0.0077819168,
-0.016775077,
-0.029226145,
-0.016683908,
0.008413587,
0.0182989,
0.019679459,
0.009168986,
0.014261421,
-0.011571938,
0.036545705,
-0.03201331,
0.025084471,
-0.014951699,
-0.011304944,
0.019119421,
-0.007072102,
0.009299228,
-0.007287,
0.0011461233,
0.011584962,
-0.0060269153,
-0.003663036,
0.0029239168,
0.024407217,
0.00049857993,
-0.01015882,
0.0137795275,
0.0418335,
-0.030606702,
0.014000938,
0.013349731,
-0.008726166,
0.0029776413,
0.0046984544,
0.013336708,
0.0020040877,
-0.013310659,
0.00074400334,
-0.024615603,
0.0418335,
-0.001826634,
0.009292715,
0.00993741,
0.004148185,
0.0023638792,
-0.12034295,
-0.031622585,
0.0029711293,
0.024641652,
0.007684236,
0.02076046,
-0.01930176,
-0.0035881475,
0.0027822794,
0.027975827,
0.007892622,
-0.009045257,
-0.011695667,
-0.012770158,
0.022544766,
-0.0036272197,
-0.0065283445,
-0.02211497,
-0.02271408,
0.029825253,
0.025305882,
-0.0373532,
0.023964396,
-0.007176295,
0.0029092648,
0.0010818166,
-0.005414781,
0.019887844,
0.003047646,
0.046730574,
0.0029678734,
0.010132772,
0.009266667,
-0.008556852,
-0.015186134,
-0.04277124,
0.020070182,
-0.016996488,
0.040426895,
-0.0065185763,
0.018442165,
0.0011729855,
0.005772945,
-0.017426284,
0.022583839,
-0.010100212,
-0.025918016,
-0.004092832,
-0.008817335,
0.0134409005,
-0.012047319,
-0.042120032,
-0.033966925,
-0.004073296,
0.022831297,
-0.0036239638,
0.0014676565,
0.030346218,
-0.025944063,
-0.008993161,
-0.014560975,
0.0022694543,
-0.005870626,
0.019796675,
0.009787632,
-0.014066058,
-0.014639121,
-0.024446288,
-0.00011864167,
-0.009976482,
-0.008817335,
0.019002203,
-0.011435185,
0.020656267,
-0.041442778,
0.007977279,
-0.018285876,
0.0004147371,
0.021815415,
-0.038369082,
-0.0056427037,
-0.007410729,
0.012835278,
-0.00082336913,
0.022375453,
0.012105927,
0.014066058,
0.0048319516,
-0.007645163,
-0.016931366,
-0.019783651,
0.040270604,
-0.011181214,
-0.02003111,
0.016097823,
0.016006654,
-0.015290326,
-0.0016092939,
0.0167881,
-0.006616257,
-0.015550809,
-0.013011104,
-0.046678476,
0.017504428,
-0.0006923138,
-0.0006341122,
0.008478708,
0.00345465,
0.014443758,
-0.00769726,
-0.005580839,
0.0037835094,
-0.046053316,
0.037483443,
-0.0031388148,
0.00006695216,
-0.01958829,
0.009377372,
0.042927526,
0.04139068,
0.025110519,
0.028548889,
-0.02675156,
0.016475523,
0.0058217854,
0.017817007,
0.02659527,
0.013349731,
0.0024778405,
0.032377984,
-0.01892406,
-0.015329399,
-0.0038746782,
-0.0069679087,
-0.0072544394,
0.0032267277,
-0.015602905,
-0.011239823,
0.00092715514,
0.0023166668,
0.03792626,
0.034019023,
-0.01614992,
-0.008153104,
0.011142142,
0.00050712697,
-0.029174047,
-0.0004468904,
-0.031179763,
0.02946058,
0.0072935116,
-0.0014326541,
-0.008478708,
0.013011104,
0.0036858283,
-0.029278241,
-0.027064139,
0.017986322,
-0.00444774,
-0.013675335,
-0.025983136,
-0.008648021,
0.005453854,
0.014587023,
-0.0038290936,
0.0073325844,
0.003542563,
-0.002212474,
-0.00754097,
-0.012314313,
0.031700727,
-0.04331825,
-0.039541252,
0.0055026943,
-0.031804923,
0.008192177,
0.0030053176,
-0.009481565,
-0.010132772,
0.022622911,
0.0046463576,
0.028001877,
-0.010217428,
0.010028578,
-0.035634015,
0.025344953,
-0.0055254865,
-0.005587351,
0.0014570743,
0.016488547,
0.010810027,
0.006313446,
-0.009195034,
0.024876084,
-0.013844648,
0.022245212,
-0.00769726,
0.02009623,
-0.011552402,
0.0011274011,
-0.0031013705,
0.009103865,
-0.0058576018,
0.011552402,
-0.025761725,
0.007085126,
-0.01996599,
0.015720123,
-0.013584166,
-0.05214861,
-0.0110119,
0.0035230268,
0.027506959,
0.012718061,
0.009383884,
-0.006668354,
-0.0016402261,
0.01816866,
0.011129118,
0.0045649568,
0.008993161,
0.007072102,
-0.007814477,
0.013492997,
-0.000051307943,
-0.011031437,
0.028210262,
0.000050799186,
0.021346547,
-0.016931366,
0.019926917,
-0.014495855,
0.0047277585,
0.008986648,
-0.026907848,
-0.0072479276,
0.017595597,
-0.012105927,
-0.024719795,
-0.01120075,
-0.033524107,
0.06678773,
-0.017074632,
-0.005893418,
0.00003324714,
0.015094965,
0.014183275,
0.007287,
0.0066618416,
-0.015550809,
-0.02038276,
0.020434856,
-0.02526681,
-0.0155638335,
-0.032377984,
-0.012568284,
0.0065413686,
-0.0003138001,
0.0031518391,
0.0029874095,
-0.020877678,
0.0056589837,
0.0014920767,
0.010373718,
-0.015967581,
-0.030268075,
-0.01672298,
0.0066748657,
-0.013961866,
-0.0071697826,
-0.017986322,
-0.014144204,
0.043865263,
-0.023248069,
-0.020174375,
0.008244273,
-0.013063201,
-0.00610506,
-0.020109255,
0.0046984544,
-0.001517311,
-0.014521903,
0.0154726645,
-0.024771892,
-0.026933897,
-0.0025169128,
-0.021997754,
-0.006606489,
-0.003998407,
-0.03883795
] |
Embryonic stem cells have an unlimited potential for self-renewal yet are pluripotent, capable of differentiating into three different germ layers and ultimately into multiple cell lineages. Key pluripotency specific factors maintain an undifferentiated ES cell phenotype while lineage specific factors work in opposition to promote cell specialization. In addition to these important transcriptional regulators, epigenetic modifiers play a defining role in regulating the balance between pluripotency and differentiation by promoting changes in chromatin structure. | [
-0.013003275,
-0.0023918026,
-0.008754096,
-0.024275402,
-0.030898351,
0.00018493847,
-0.016380323,
0.017757371,
-0.023383599,
-0.014898356,
0.0048131132,
0.003419671,
-0.016577045,
0.0013499996,
-0.008655735,
-0.0068655717,
0.033704907,
-0.006681965,
0.002570491,
0.03669507,
-0.009095079,
-0.00016014339,
0.0013098357,
-0.024472123,
-0.015685242,
0.019816387,
-0.002632786,
-0.025665566,
-0.0066458997,
-0.02887868,
0.013167209,
0.011350816,
-0.00944262,
0.002355737,
-0.03194753,
0.001878688,
-0.013560652,
-0.0355672,
0.011639341,
0.013954094,
0.020799994,
0.015291799,
-0.021298354,
-0.00040635234,
0.009409833,
0.002455737,
-0.009711472,
-0.005078687,
-0.019803273,
0.03769179,
0.017652454,
0.0012262291,
-0.0122360615,
-0.0042360644,
-0.030636055,
-0.001736065,
0.007659014,
0.014832783,
0.0052426215,
-0.0009950816,
-0.0052295066,
0.0013549177,
-0.00839344,
0.017901633,
-0.017075405,
0.024196714,
0.001139344,
0.008216391,
0.023186877,
-0.0002967212,
0.017547535,
-0.0108721275,
0.007409834,
-0.007986883,
-0.0025360647,
-0.018347535,
-0.012885242,
-0.005363933,
-0.00055614737,
0.016931143,
0.0030049172,
-0.027173761,
-0.012813111,
0.008170489,
0.0036262283,
0.0071934406,
0.013495077,
0.008478686,
0.014872126,
0.0013393438,
0.020537699,
0.03202622,
0.040236052,
0.005937703,
0.0020049175,
-0.0030557367,
0.014518028,
0.024013108,
-0.0051245885,
-0.019514749,
-0.012655734,
0.024485238,
-0.004708195,
-0.02255737,
-0.051645886,
0.0002058401,
0.023095075,
-0.010465571,
0.035934415,
-0.003767212,
-0.01648524,
0.0007172129,
-0.0079540955,
-0.045403264,
0.037245892,
0.003185245,
0.0023213108,
0.010531144,
-0.03981638,
0.010727866,
0.018754093,
0.014767208,
0.02123278,
-0.044485234,
0.027173761,
0.018032782,
-0.003514753,
0.008747539,
-0.025639337,
0.010078685,
0.018491797,
-0.0050557363,
-0.006232785,
0.029560646,
-0.02550819,
-0.017324585,
-0.009678685,
-0.010039342,
0.0044557364,
-0.015173766,
0.010845899,
0.018518027,
-0.022347534,
0.0063081947,
0.00016793028,
-0.0027868843,
0.016340978,
-0.0018655732,
0.029954089,
0.016760651,
-0.0043311464,
-0.01061639,
0.047973756,
0.00065860635,
-0.0049999985,
-0.0049180314,
0.025140977,
0.011331144,
-0.024498353,
0.013927865,
-0.001936065,
-0.009436063,
0.007659014,
0.0112983575,
0.008675408,
0.032419663,
-0.005252457,
0.008911473,
0.011409832,
0.005540982,
-0.0029098352,
0.02388196,
-0.048104905,
0.0075475387,
-0.015291799,
0.005088523,
-0.018662289,
0.0042786873,
-0.038504906,
-0.013108193,
0.0045245886,
0.013757373,
0.03152786,
0.01593442,
-0.019396715,
0.0070163915,
0.006003277,
-0.002136065,
-0.0013909832,
0.00038196708,
-0.027672123,
-0.0014499995,
0.030032778,
-0.0052721296,
-0.6399998,
-0.032445893,
0.014950815,
-0.017744256,
0.022963928,
0.032419663,
-0.0017508192,
-0.01548852,
-0.023068845,
0.011259013,
-0.022399994,
0.005239343,
-0.0011032784,
-0.0071016373,
-0.010419669,
-0.037219662,
-0.0019459011,
-0.016681962,
0.009986882,
0.0023918026,
-0.006931145,
0.00081434404,
-0.024511468,
0.032524582,
-0.0008754096,
0.013331143,
0.03790163,
0.0065737683,
-0.017744256,
0.025639337,
-0.0140983565,
0.01036721,
-0.018255733,
-0.007481965,
0.045534413,
0.025993435,
-0.027672123,
0.016340978,
-0.0005815572,
0.06017047,
-0.011731144,
-0.004350818,
0.033731136,
0.0065967194,
-0.012701635,
0.008026227,
0.0016081962,
0.017022945,
-0.0014254093,
-0.012288521,
0.02023606,
0.015304914,
-0.016406553,
-0.009357374,
0.031003268,
0.0051508183,
0.013147537,
-0.00006526637,
0.0071934406,
-0.01246557,
-0.0033540973,
0.014032783,
-0.036983594,
-0.012754095,
-0.009770488,
0.029691795,
-0.011009833,
0.000941803,
0.0045475396,
-0.031344254,
0.0104918005,
0.021442616,
-0.023199992,
-0.010354095,
-0.004134425,
0.019567207,
-0.0028950812,
-0.015659012,
0.0108721275,
0.0014081963,
-0.004501638,
-0.016734421,
-0.004665572,
0.038111463,
0.0230295,
-0.0021475402,
0.002999999,
0.0071409815,
-0.014360651,
0.0061114733,
0.007121309,
0.0067934403,
0.009698357,
-0.054347523,
-0.030714745,
0.017573765,
-0.021626223,
-0.0012360652,
-0.0044754082,
-0.030163925,
-0.012950815,
-0.009672129,
0.0071803257,
0.020472124,
0.009383604,
0.007062293,
-0.009724587,
-0.00017643438,
0.03215737,
-0.019803273,
0.0028737695,
0.0010319669,
-0.01596065,
-0.007724588,
0.010275407,
-0.02078688,
0.0010024587,
-0.000036424168,
-0.020288518,
-0.032340974,
0.0014655733,
-0.02020983,
-0.011645898,
0.0145967165,
-0.0007360653,
-0.00024016386,
0.009265571,
-0.010163931,
-0.0028836057,
-0.001139344,
-0.0050950805,
-0.017678684,
0.013416389,
-0.028931139,
0.018045897,
0.005875408,
0.008170489,
-0.0032508187,
0.01576393,
-0.012157373,
-0.019475404,
-0.020026224,
0.020996714,
-0.0130426185,
-0.02200655,
-0.011232783,
-0.009239341,
-0.0055442606,
0.0119868815,
-0.02495737,
0.0016729503,
0.011219669,
-0.014990159,
0.012701635,
0.02518032,
-0.0022770485,
-0.014321307,
-0.021101633,
0.012583603,
-0.014426225,
-0.0177836,
0.018609831,
-0.01246557,
0.005026228,
0.003927868,
-0.014806553,
-0.02255737,
-0.0012262291,
-0.0060459,
-0.030819662,
-0.014426225,
-0.0057213097,
-0.004216392,
0.007042621,
-0.018163929,
-0.010124587,
-0.0047967196,
0.0071278666,
0.014203275,
-0.005885244,
-0.00866885,
-0.012459013,
-0.0076065552,
-0.020839337,
0.035278678,
0.0132196685,
0.02440655,
0.01731147,
0.012380324,
0.009672129,
0.0021622945,
0.018740978,
-0.006288523,
0.01548852,
0.011521308,
-0.040104907,
-0.006157375,
0.010504914,
-0.00028073761,
0.03297048,
0.014950815,
-0.0046622935,
0.004583605,
-0.028931139,
0.006150818,
-0.047029495,
-0.011665571,
-0.00592131,
-0.011501635,
0.02255737,
-0.003629507,
0.013927865,
-0.012150816,
-0.013718029,
0.0040983595,
-0.0075606536,
-0.013272127,
-0.014268848,
-0.015252454,
0.003342622,
0.00054918014,
-0.0153442575,
0.017508192,
-0.005990162,
-0.0022540977,
0.015291799,
0.0042098346,
0.0022131142,
-0.0015090159,
-0.010137701,
0.01361311,
0.007383604,
0.016813109,
-0.011888521,
0.030399991,
0.01993442,
0.020249175,
-0.02487868,
0.028196713,
-0.011363931,
-0.00457049,
0.00801967,
0.0014672127,
0.0062459,
-0.013875405,
-0.022570485,
0.042334415,
-0.00012561472,
-0.021665568,
0.0040852446,
-0.018059012,
0.012799996,
-0.021744255,
0.0005659834,
0.01496393,
-0.008714751,
-0.0070163915,
-0.0034557367,
0.020314747,
0.01066885,
0.008767211,
-0.021167208,
-0.001046721,
-0.00367213,
0.0065278667,
-0.0031655729,
-0.0021999993,
-0.01394098,
-0.02413114,
-0.014006553,
-0.022465566,
0.014544258,
0.017167209,
-0.009062292,
-0.016314749,
-0.0065311454,
0.018491797,
0.009836063,
-0.009868849,
0.0054360637,
-0.00919344,
-0.002837704,
0.032209825,
0.037140973,
-0.004773769,
0.0014672127,
-0.023895076,
-0.016839338,
0.013304914,
0.01101639,
0.008622948,
0.0038983594,
-0.010859013,
0.003986884,
-0.015383602,
-0.007724588,
-0.0048196707,
-0.016354093,
0.026163926,
-0.00854426,
0.030216385,
-0.016773766,
-0.0074950797,
0.020039339,
0.031081958,
0.011967209,
-0.01598688,
0.0017180323,
-0.006413113,
-0.026308188,
-0.02550819,
-0.035462283,
-0.015160651,
-0.00031311467,
0.008865571,
-0.0012499996,
0.023016386,
0.0035606546,
0.025639337,
0.0013786881,
-0.004009835,
-0.004540982,
-0.0049770474,
0.005426228,
0.03659015,
0.019580321,
0.0024114747,
0.01811147,
-0.004881966,
-0.008734424,
-0.0027032779,
-0.011442619,
0.018636059,
-0.016183602,
0.010819669,
-0.002203278,
0.0073049157,
-0.006157375,
0.010563931,
0.018950814,
-0.015370487,
-0.01965901,
-0.020983601,
-0.015029504,
-0.00242295,
-0.004324589,
0.011698357,
0.040839333,
0.012898357,
0.008622948,
0.009213112,
0.00597049,
-0.017219666,
0.01024262,
-0.013691799,
0.016196717,
-0.002985245,
0.0018147535,
-0.0027868843,
-0.033731136,
0.008170489,
0.012524586,
0.0054393425,
0.021639338,
0.03519999,
0.013324586,
0.000981967,
-0.020577043,
-0.014832783,
-0.0026737696,
-0.008760653,
0.0045377035,
-0.0066360636,
-0.022793436,
0.0023245895,
-0.020721305,
-0.022085238,
-0.006360654,
0.011927865,
0.003806556,
0.0041901628,
-0.0064360634,
-0.010104915,
-0.013573767,
-0.000816803,
-0.032734416,
0.02772458,
0.007409834,
-0.0100918,
0.0037967202,
0.00035204907,
-0.008098358,
-0.0147147495,
-0.0027491795,
0.029796712,
-0.01990819,
-0.03994753,
0.009383604,
0.0033377039,
0.03462294,
0.011580325,
-0.016498355,
-0.0010909833,
0.02887868,
0.02590163,
-0.023567205,
0.002952458,
-0.01916065,
-0.00066434406,
0.0127934385,
0.011803275,
-0.016957372,
-0.014675405,
-0.0020065568,
0.015422946,
-0.015055733,
0.0106229475,
-0.0017213109,
-0.03509507,
0.021980321,
0.019672126,
0.016813109,
0.0039737695,
-0.010124587,
-0.011003275,
-0.031239334,
-0.014426225,
-0.01841311,
-0.0018442618,
-0.011613111,
-0.0074754073,
-0.0021934418,
-0.03784917,
-0.01061639,
0.024367206,
-0.009645899,
0.020642616,
0.003534425,
0.01126557,
-0.0010524587,
-0.006806555,
0.0096262265,
-0.0052590147,
-0.0032081958,
-0.009999997,
-0.02388196,
0.028563926,
0.003862294,
-0.020301633,
-0.007167211,
0.025875403,
-0.0069114733,
-0.023042616,
-0.0025475402,
-0.00029733597,
0.04569179,
-0.0007036883,
-0.00866885,
-0.00096639316,
0.0022803273,
-0.010767209,
0.029744253,
0.018977044,
-0.014583602,
0.0050557363,
0.004514753,
0.0000234503,
-0.023095075,
0.02725245,
-0.032498352,
0.003185245,
0.02131147,
0.011121308,
0.015672127,
0.0051049166,
0.0049672117,
-0.018045897,
-0.022937698,
-0.017272126,
-0.018727863,
0.0010418029,
-0.043855723,
0.04818359,
0.043829493,
0.023475403,
0.0045081954,
0.0061442605,
0.032419663,
0.011475407,
0.0057245884,
0.0035573759,
0.03766556,
-0.025665566,
0.028747533,
-0.017403273,
0.0063639325,
0.022596715,
-0.017927863,
0.0066918014,
0.053770475,
-0.030111466,
-0.016026225,
0.0031819663,
-0.026321303,
-0.034281958,
0.016865568,
-0.008832784,
0.0135999955,
-0.020432781,
0.008314751,
-0.0041934415,
0.008898358,
-0.011521308,
-0.0028098351,
0.012052455,
-0.008655735,
0.031422943,
0.00259836,
0.005678687,
-0.013370488,
0.010786882,
-0.016944258,
-0.023960648,
-0.0004766392,
0.011436062,
0.015042618,
0.015777044,
-0.00592131,
-0.0061868834,
0.020629501,
-0.021940976,
-0.01101639,
-0.019173764,
-0.032314744,
-0.0020032781,
-0.006629506,
-0.016288519,
-0.020104911,
-0.010209833,
0.0021819666,
-0.01913442,
0.012557373,
-0.017298356,
-0.0074295057,
0.014950815,
-0.013783602,
0.013199996,
0.0018196716,
0.013206554,
0.042177036,
0.007514752,
-0.019304913,
-0.02675409,
-0.024026223,
0.0045770477,
0.040026218,
0.0051639327,
0.0033836055,
-0.02255737,
0.003986884,
0.0070229485,
-0.016340978,
-0.020091796,
-0.0066065555,
-0.02992786,
-0.011055734,
0.0026393435,
0.0058721295,
-0.0047245887,
-0.00302295,
-0.0046590148,
0.031370483,
-0.009239341,
-0.0012180324,
-0.018557372,
0.03315409,
-0.00091885217,
0.0054459,
0.018793438,
0.0129836025,
-0.008111473,
-0.032314744,
-0.0138491765,
0.0076655713,
0.0012819668,
0.021377042,
-0.022845894,
0.011999996,
0.009790161,
-0.0006122949,
-0.010321308,
0.0017918027,
0.0018147535,
0.036957365,
-0.025416385,
-0.009199997,
0.01913442,
-0.00229836,
0.02775081,
-0.00824262,
-0.019108191,
0.0021901634,
-0.026137697,
-0.0091868825,
0.031291794,
0.010839341,
0.0126622915,
-0.0035180317,
-0.0124918,
-0.01965901,
-0.032419663,
-0.028983599,
0.0033327858,
-0.02838032,
0.008806555,
0.021363927,
0.044904903,
0.022740977,
-0.011232783,
0.0085114725,
-0.00090573746,
0.017744256,
-0.00009185448,
0.034859005,
0.019239338,
0.009901636,
-0.03186884,
-0.0032852448,
-0.0010836063,
-0.021691797,
-0.016327864,
-0.01366557,
-0.032340974,
0.013206554,
0.0017459011,
0.026544254,
0.0012344258,
-0.022295075,
-0.011809832,
0.008931145,
0.024760649,
-0.014360651,
-0.029639335,
-0.00999344,
-0.028957369,
-0.021718025,
0.013180324,
-0.0071737682,
-0.002852458,
-0.0033704909,
-0.020354092,
0.00026188517,
-0.02175737,
-0.00090163905,
-0.01366557,
-0.002537704,
-0.007888522,
0.012570488,
0.024118025,
-0.021665568,
-0.006832785,
0.005563933,
-0.0026983598,
-0.018649174,
-0.032839336,
0.008747539,
0.024091795,
0.014767208,
0.0075803255,
-0.014701635,
-0.007462293,
-0.042150807,
-0.01731147,
0.008236063,
-0.0142163895,
0.04139015,
0.032472122,
-0.0054721297,
-0.009750817,
-0.0040360643,
-0.054714736,
-0.038452446,
0.011331144,
0.015659012,
0.009239341,
0.00041434413,
-0.0035409825,
-0.022150813,
0.0051081954,
0.010255734,
0.0059409817,
-0.026596714,
0.012413111,
-0.0059934407,
0.019895077,
0.0027032779,
-0.030924581,
-0.014281963,
0.03215737,
-0.02131147,
-0.00039610642,
0.005537703,
-0.021062288,
0.03981638,
-0.0040426217,
0.042045888,
0.021796715,
0.031737696,
0.022229502,
-0.016826224,
-0.007816391,
0.017901633,
-0.0050852443,
-0.008229505,
0.00088360626,
-0.010799997,
-0.0061999983,
0.019318027,
-0.009731145,
-0.0076065552,
-0.009199997,
-0.007042621,
0.03186884,
0.009547538,
0.018701633,
0.012459013,
0.027488517,
0.003567212,
-0.0098754065,
0.0028622942,
0.002960655,
0.010885242,
-0.0006180326,
-0.015750814,
-0.0122950785,
-0.0041377037,
-0.020432781,
-0.013304914,
-0.005255736,
0.0100918,
-0.017822945,
-0.008485244,
0.013718029,
-0.004557376,
-0.016340978,
-0.009311473,
-0.004491802,
-0.017193437,
-0.021993436,
-0.00040614742,
-0.0034065563,
-0.005288523,
-0.003967212,
-0.021914747,
0.0021163928,
-0.00063114736,
0.007259014,
0.0007036883,
-0.003691802,
0.016983602,
0.18580978,
-0.007029506,
-0.00051721296,
0.0031131138,
0.0035901628,
-0.006167211,
0.007285244,
-0.0052590147,
-0.013718029,
0.0011245898,
0.008209834,
0.013652455,
-0.012786881,
-0.0017016388,
0.04097048,
-0.031422943,
-0.018740978,
-0.0011459013,
-0.009337702,
0.00078278664,
0.010268849,
-0.016577045,
0.021954091,
-0.005003277,
0.0330754,
0.009449177,
-0.024039337,
0.015016389,
0.027042614,
-0.003014753,
-0.018177044,
0.0019196715,
0.0044131135,
0.020603273,
0.019816387,
-0.017993437,
-0.006409834,
-0.00984262,
0.021350814,
-0.021429501,
0.009344259,
0.016681962,
0.002170491,
0.0033606547,
0.009711472,
0.028485237,
-0.009540981,
-0.0055999984,
0.021927861,
-0.015999995,
-0.018636059,
0.031029498,
0.009390161,
0.015409831,
0.00024241795,
0.017206552,
0.015921306,
0.0111803245,
-0.0051868837,
0.022085238,
-0.0010950817,
0.006232785,
-0.03622294,
0.0069901617,
0.0017213109,
0.01678688,
-0.011809832,
-0.009914751,
0.015226224,
-0.02230819,
-0.004177048,
0.0021196716,
-0.010059013,
0.027121304,
-0.003786884,
-0.03186884,
0.03412458,
-0.012229504,
0.016773766,
0.016301634,
0.019331142,
0.009436063,
-0.04731802,
-0.013245897,
0.016577045,
-0.03795409,
0.04089179,
0.0012827865,
-0.039501626,
-0.012498356,
0.012229504,
-0.0056163915,
0.0016286881,
-0.0032213104,
0.00921967,
-0.01645901,
0.0015319667,
0.006891801,
0.005934424,
-0.014229503,
-0.027147533,
0.07160653,
0.02283278,
0.037036054,
-0.00045081953,
0.025062287,
0.007285244,
-0.019029502,
-0.006754096,
-0.008563932,
0.019580321,
-0.019121306,
0.016603274,
-0.004462294,
-0.02076065,
0.011993439,
0.010249177,
-0.02435409,
0.060065556,
-0.0041147526,
-0.017665569,
-0.021534419,
-0.001726229,
0.018150814,
-0.00059221295,
-0.012170488,
-0.013508192,
0.0153442575,
-0.023672124,
-0.019068846,
-0.022321304,
-0.018793438,
0.0033704909,
0.011350816,
0.014924586,
-0.026491795,
0.0077967187,
-0.0041836053,
-0.020262288,
0.020537699,
-0.0043606544,
-0.0038459005,
0.005075408,
0.0046032774,
0.0071409815,
-0.017731141,
0.012609832,
0.021036059,
-0.012668849,
-0.02131147,
-0.013278685,
-0.021390157,
-0.013252455,
0.0041278675,
0.022544255,
-0.010799997,
-0.010813111,
-0.02540327,
-0.000014395488,
0.0031967203,
-0.012013111,
0.031554088,
-0.022649173,
-0.014203275,
0.013508192,
-0.023226222,
-0.16325241,
-0.010636062,
0.02937704,
-0.024262287,
0.038006544,
0.020275403,
0.0033868842,
-0.012911472,
-0.021022944,
0.0022672124,
0.02730491,
-0.00032991794,
-0.05345572,
-0.03299671,
0.03205245,
0.008839342,
0.008898358,
0.053324573,
0.012334422,
0.021744255,
0.017363928,
-0.028799992,
0.0005565572,
0.008078686,
0.012347537,
-0.010747538,
0.013481963,
-0.008983604,
-0.015999995,
-0.027567204,
-0.012472128,
-0.0021163928,
0.027960647,
0.008747539,
0.0010926226,
-0.0099344235,
0.0055737686,
-0.0145967165,
-0.0021868846,
0.03522622,
0.017363928,
-0.003901638,
-0.004734425,
0.009350817,
0.00047868837,
0.045534413,
-0.02730491,
-0.011718029,
0.015396717,
-0.004029507,
0.010636062,
-0.0040327855,
-0.023868846,
0.01039344,
0.0230295,
-0.013068848,
0.014150815,
0.0152131105,
0.0009852456,
-0.010190161,
-0.005331146,
0.017639339,
0.03464917,
-0.006114752,
-0.005131146,
-0.022150813,
0.0044295066,
0.0155934375,
-0.034859005,
0.0031672122,
-0.0045639332,
0.00042704906,
0.016734421,
-0.019108191,
0.038478676,
0.000249795,
0.0050557363,
0.02120655,
-0.0034557367,
-0.011875406,
-0.028511466,
0.013331143,
-0.018636059,
-0.018098354,
-0.016170487,
0.0025163926,
0.012118029,
0.026177041,
-0.016708191,
-0.009298358,
0.023986878,
-0.027016385,
-0.0091868825,
0.0022737698,
0.012747537,
0.018295076,
0.0063213096,
-0.038609825,
-0.013927865,
-0.0005090162,
0.039055727,
-0.003452458,
-0.012380324,
0.0038852447,
0.04820982,
-0.0036557366,
-0.022793436,
0.006727867,
0.072708175,
-0.014740979,
0.0088786855,
0.0076983585,
-0.002040983,
0.013154094,
0.010570489,
0.03669507,
0.007377047,
0.009311473,
0.0091868825,
-0.027409827,
0.06289834,
-0.005019671,
0.005308195,
0.053718016,
0.0072131124,
-0.009101637,
-0.14646553,
-0.023514748,
-0.000020389338,
0.025718024,
-0.01326557,
0.021940976,
-0.011475407,
0.011127866,
-0.007239342,
0.023527863,
-0.018399995,
-0.02233442,
0.008052456,
-0.023986878,
0.027619664,
0.00013032783,
0.0029442613,
-0.0045770477,
-0.03567212,
0.037009824,
0.006872129,
-0.009790161,
-0.012321307,
-0.0117377015,
0.010832784,
0.038504906,
-0.04262294,
0.008452456,
0.017914748,
0.025022943,
-0.0025114745,
-0.015895078,
0.0057114735,
-0.010111473,
-0.00734426,
-0.0028606548,
0.002208196,
-0.031580318,
0.016472125,
-0.012504914,
-0.0027114747,
-0.009134423,
0.0147147495,
-0.008399998,
0.00034836054,
-0.014268848,
-0.021403272,
-0.010885242,
0.016288519,
-0.0127934385,
-0.051462278,
-0.011357374,
-0.016904913,
0.0055213096,
0.012131143,
-0.00904262,
0.01126557,
0.002278688,
0.0088918,
0.0065508178,
-0.006832785,
-0.009455735,
-0.016078684,
-0.02435409,
0.0035770482,
-0.009331144,
-0.03207868,
-0.030347532,
0.008649178,
-0.021468846,
-0.0053147525,
0.009022948,
0.0006713113,
0.015278684,
-0.015554094,
0.0177836,
-0.011088521,
-0.011770488,
-0.0018327864,
-0.017718026,
-0.0011614751,
-0.014937701,
0.0019065568,
-0.00557049,
0.027409827,
0.0021229503,
0.01548852,
-0.026190156,
0.0075081945,
-0.0067409817,
-0.019855732,
0.038242612,
0.020695075,
-0.024616387,
-0.0045049167,
0.008360653,
0.00053688505,
-0.016852453,
0.030032778,
0.027986877,
0.00005655736,
-0.015750814,
-0.037272118,
0.009226226,
-0.012098357,
-0.0019098355,
-0.02310819,
0.00078483584,
0.016603274,
-0.015501634,
0.0007901637,
0.00080122927,
0.01935737,
0.0013975406,
-0.014806553,
-0.005934424,
-0.03889835,
-0.024118025,
0.02125901,
-0.009278686,
0.0020016388,
0.027042614,
0.0023278682,
-0.01645901,
0.005662293,
-0.007724588,
-0.02772458,
-0.0015819668,
-0.016695077,
0.009003276,
-0.018478682,
-0.021547534,
0.005288523,
-0.034491792,
-0.022045895,
0.012636062,
-0.019868847,
-0.0028147532,
0.016904913,
0.050596707,
0.02068196,
0.03297048,
-0.0020245896,
-0.027199991,
0.03312786,
-0.0072786864,
-0.014845897,
0.012209833,
-0.035986874,
0.015881963,
-0.009999997,
-0.016642617,
0.040865563,
0.012347537,
0.01246557,
-0.007862292,
0.009088522,
-0.025036057,
0.006662293,
0.0056295064,
-0.0049475394,
-0.010150816,
0.018452452,
0.023973763,
0.015226224,
-0.017298356,
-0.01758688,
-0.007626227,
-0.01596065,
-0.008714751,
-0.005442621,
-0.028537696,
-0.030059008,
0.0056590145,
0.01830819,
0.008852457,
0.019186879,
0.00452131,
-0.004701638,
0.013993438,
-0.028249172,
0.022767207,
0.0015467209,
0.0068655717,
-0.0055868835,
-0.0032836054,
0.03792786,
-0.0032786876,
-0.011324586,
0.023724582,
-0.0072524566,
-0.0018344256,
-0.023449173,
-0.00032643432,
-0.004855736,
0.009324587,
0.019790158,
0.010773767,
-0.017521307,
0.014990159,
-0.0039639333,
0.020865567,
-0.0075081945,
0.016550815,
0.038111463,
-0.02832786,
-0.0088196695,
0.01366557,
-0.02355409,
-0.020380322,
-0.013547537,
-0.0012704914,
-0.0023393435,
0.009586882,
-0.014859011,
-0.004744261,
-0.02835409,
0.013403274,
0.00012838111,
-0.012819668,
-0.01114098,
0.027147533,
0.021914747,
0.023750812,
-0.00706885,
0.0034557367,
0.0064983587,
0.0021721304,
0.031763926,
-0.010157374,
0.033731136,
0.00087786856,
0.021599993,
0.0078229485,
0.0028934418,
-0.011396718,
-0.02785573,
-0.011914751,
0.00709508,
0.025219664,
-0.014059012,
0.067042604,
0.001146721,
-0.04136392,
0.013252455,
0.0021622945,
0.029980319,
0.011213112,
0.016996715,
-0.028511466,
-0.0073704896,
0.020091796,
-0.030373761,
-0.00072909816,
-0.017770486,
0.011003275,
0.01761311,
-0.016577045,
0.0093770465,
-0.016799996,
-0.009888521,
0.018242618,
-0.01601311,
0.0038098348,
0.017416388,
-0.03199999,
-0.012472128,
0.034281958,
-0.0077836043,
0.010177046,
-0.011462292,
0.011029505,
0.004786884,
-0.047580313,
0.006314752,
-0.0036983595,
0.019527864,
-0.0005086064,
-0.029744253,
0.02415737,
0.023514748,
-0.017940978,
0.00529508,
-0.000018724379,
-0.020262288,
-0.007777047,
-0.0025491796,
-0.011973767,
-0.010780324,
-0.006957375
] |
The National Immunization Technical Advisory Group (NITAG) in South Africa, known as the National Advisory Group on Immunization (NAGI), was established in 1993 to advise the National Department of Health (DoH) on issues related to vaccination. Meetings are held as needed but at least twice a year. The scope includes vaccines and immunization and other relevant infectious disease issues. NAGI also makes recommendations on vaccine schedules and formulations. Agendas are set by DoH and the Chairman of NAGI. NAGI brings together experts from a range of different fields relevant to vaccines and vaccinations and has been an important | [
-0.0088002095,
-0.010568319,
-0.014440681,
-0.037110128,
0.009922925,
0.018555064,
-0.015301205,
-0.008901052,
-0.0119599495,
-0.019455926,
0.003512689,
-0.030763758,
0.019617274,
0.003131167,
-0.0006222837,
-0.031140238,
0.04022953,
-0.0070724376,
-0.00800019,
-0.013741504,
-0.017022254,
0.01753319,
0.0011638933,
0.02472664,
-0.0014647408,
0.014104538,
-0.0033345332,
-0.031113347,
-0.011180098,
-0.0073413514,
-0.0038118556,
-0.023771996,
0.018985327,
0.0009218707,
-0.002734519,
-0.01351965,
0.0033126841,
-0.022951808,
0.022400534,
0.0036874828,
0.024256041,
-0.0007117817,
0.012060792,
-0.0021647576,
0.0057581207,
0.013075942,
-0.00048236444,
0.011496073,
-0.022360196,
0.02097529,
-0.009741409,
-0.00022752643,
-0.020733267,
-0.0081144795,
-0.00995654,
-0.0036908444,
-0.02163413,
0.0074354713,
-0.0074825315,
-0.028612446,
-0.017102929,
-0.016511317,
-0.025735067,
-0.0025899778,
-0.0007890944,
-0.0045715375,
-0.008235491,
0.012625511,
-0.015328096,
0.00026282138,
0.025210686,
0.051900398,
0.006242166,
-0.011993564,
0.02441739,
0.001998367,
-0.02238709,
0.0041984194,
-0.016968472,
0.010507814,
-0.0026185499,
-0.0070321006,
-0.01653821,
0.01828615,
0.017734876,
0.0029210781,
0.0096809035,
0.021782031,
0.023207275,
-0.018447498,
0.002260558,
0.016470982,
0.023825778,
0.019294579,
-0.010494368,
0.015865924,
0.0017849165,
0.025277914,
0.0114355665,
0.0061077084,
-0.019590383,
0.0031614199,
-0.010601933,
-0.012961654,
-0.0066858735,
-0.005606856,
-0.013311242,
-0.007953131,
0.016981918,
-0.009593506,
-0.01509952,
0.03444788,
-0.00604048,
-0.037782412,
0.0031160407,
0.0051732324,
0.023960235,
-0.003418569,
-0.0059934203,
-0.030656192,
0.020289559,
0.014669257,
0.013149894,
-0.00967418,
0.03998751,
0.012813751,
-0.008369948,
-0.021768587,
-0.0031177213,
-0.027859489,
0.0030168786,
0.007899348,
0.010864125,
0.01807102,
0.009264086,
-0.006820331,
-0.024215704,
0.005270714,
-0.019657612,
0.0024605629,
0.026582146,
0.036814325,
-0.0087733185,
-0.011912889,
-0.013701167,
0.034098294,
0.03944968,
0.016847461,
0.0021294625,
0.014010418,
0.005754759,
-0.015650794,
0.009492664,
-0.015274314,
-0.007872457,
0.016309632,
0.0030874687,
0.014763378,
-0.020168548,
0.007025378,
-0.021741696,
-0.005304328,
0.0075161457,
0.0008483396,
0.009176689,
0.025560273,
-0.024887988,
-0.021540008,
0.0103935255,
0.0075161457,
0.023408962,
0.039422788,
0.0037143743,
0.0025916584,
-0.005579965,
0.007186726,
0.012719631,
0.0195366,
-0.0148978345,
0.009983432,
0.017116375,
0.012827196,
0.013996973,
0.02569473,
-0.05004489,
-0.0035597486,
0.013916298,
0.018084465,
0.012121297,
-0.0043967436,
0.01356671,
-0.014628921,
0.011462458,
-0.032646157,
-0.64066064,
-0.028128402,
0.040310204,
-0.001177339,
0.010978413,
-0.0017143266,
0.0053177737,
0.00019811396,
-0.0025731707,
0.03638406,
-0.013042328,
0.015825588,
0.01637686,
-0.013849069,
-0.02710653,
-0.019563492,
-0.017896226,
-0.022938361,
0.007186726,
-0.00620519,
-0.0021815647,
-0.0034420989,
0.008934666,
-0.0041379137,
-0.008927944,
0.008087588,
0.01481716,
-0.0046589347,
-0.017775213,
0.01816514,
-0.03713702,
0.012403657,
0.011247327,
-0.013808733,
0.041090056,
0.014749931,
-0.016887797,
0.021714803,
-0.00031933535,
0.0052841594,
-0.030252822,
-0.015865924,
0.01854162,
-0.008154816,
-0.0027832596,
0.024605628,
0.0037379044,
0.007186726,
0.012679294,
-0.014857497,
-0.007912794,
-0.002179884,
-0.011334724,
0.014413789,
0.0077783368,
-0.009842251,
-0.00865903,
-0.0003317306,
0.01854162,
0.02085428,
-0.0049412944,
-0.0074354713,
-0.018218921,
-0.0022756846,
-0.006410237,
0.01653821,
-0.007180003,
0.030387279,
-0.013297796,
-0.030172149,
0.01413143,
0.029257841,
-0.008403562,
0.005919469,
0.011906167,
-0.007065715,
-0.0063127554,
0.0055295434,
-0.0016218874,
0.005351388,
-0.009748132,
-0.013035605,
-0.019213904,
0.0050522215,
0.009687626,
-0.021324879,
-0.010306128,
-0.010561597,
0.0019849213,
0.0028706568,
0.015193639,
0.0127263535,
0.015489445,
-0.036115147,
0.008739704,
0.014669257,
0.00005871989,
0.0052908827,
0.0043026237,
-0.009069124,
-0.026407352,
-0.006037119,
0.0100641055,
-0.012591897,
0.008148094,
0.020746714,
-0.048565865,
0.025761958,
0.03748661,
-0.027442671,
0.0035731944,
-0.012047346,
-0.0012924678,
-0.0069984864,
0.016780231,
-0.029688103,
0.015570119,
0.012504499,
-0.00323201,
0.008605247,
0.013795287,
-0.01665922,
0.01741218,
-0.023072818,
-0.010648994,
0.00865903,
-0.012007009,
-0.0068035237,
-0.0077043856,
0.0060068658,
-0.009949817,
-0.008013637,
0.022279523,
-0.009008618,
0.048592754,
0.022467762,
-0.0097683,
0.00085002027,
0.0049581015,
-0.010111165,
-0.011657421,
-0.00027374603,
0.02644769,
-0.0019832405,
0.008349779,
-0.03194698,
-0.016175175,
0.024565293,
0.005976613,
0.038132,
0.007637157,
0.021445889,
-0.0074623628,
0.012894426,
-0.0011638933,
-0.017627312,
-0.028128402,
-0.031839415,
0.019133229,
0.015502891,
0.011885998,
0.021271095,
-0.012249031,
-0.030683085,
-0.0132507365,
-0.009250641,
0.013365025,
0.033533573,
0.022158511,
-0.04463972,
0.018057574,
-0.012134743,
-0.0065110796,
0.014360006,
0.030683085,
0.0012370043,
0.013196954,
0.0028908253,
-0.015704576,
-0.0026941819,
-0.02472664,
-0.027442671,
-0.008322887,
0.013983526,
0.022669448,
-0.008806933,
0.007892625,
-0.009848975,
0.013317965,
0.035738666,
-0.014602029,
-0.00521357,
-0.0110792555,
0.007845566,
-0.023045927,
-0.0120137315,
0.003364786,
-0.0048236446,
-0.00297318,
0.016296187,
0.014763378,
-0.0072472314,
0.023503082,
0.0030000715,
0.013586879,
0.01087757,
0.00050883566,
-0.0204778,
0.012746522,
0.0075564827,
0.027751923,
-0.00740858,
-0.0028067897,
0.01177171,
-0.0014151598,
0.00011575906,
-0.013781841,
0.0024319908,
-0.020760158,
0.014212104,
-0.0023597202,
-0.00847079,
0.040337097,
-0.011832215,
-0.037110128,
0.0068505835,
0.016887797,
0.0068976437,
0.029257841,
-0.020034092,
-0.018030683,
0.016094502,
-0.009754854,
0.015233977,
0.008195153,
0.008766595,
-0.015502891,
-0.019240795,
0.021862706,
0.011670867,
0.0053883637,
-0.010575042,
0.025277914,
-0.011072533,
0.017089482,
-0.011388507,
0.021513117,
0.013149894,
-0.020518137,
0.013459144,
-0.008625416,
-0.012605343,
-0.024242595,
-0.009654012,
-0.015839033,
-0.02550649,
0.016511317,
0.007912794,
0.020370234,
0.046280093,
0.023529973,
-0.0066051995,
0.001054647,
-0.01932147,
0.018407162,
-0.0014160002,
0.009701071,
-0.0034017619,
-0.010151503,
0.00040105998,
-0.018501282,
-0.017291168,
0.0009680903,
-0.0050186072,
0.0025580442,
0.01665922,
-0.011906167,
-0.0011807004,
-0.0047765845,
0.013970081,
0.00948594,
-0.01578525,
0.015112965,
0.0028303196,
0.006403514,
-0.0059934203,
0.0023126602,
-0.026003981,
-0.03232346,
0.011798601,
-0.016444089,
0.037970655,
-0.01715671,
0.011879275,
-0.009143075,
-0.0053950865,
-0.00311436,
-0.017465962,
-0.007986745,
-0.00095044286,
0.012894426,
-0.015247422,
-0.009701071,
-0.017654203,
0.004111022,
0.0044908635,
0.0122692,
-0.024578737,
-0.027200649,
0.025815742,
0.0063362857,
-0.019308023,
0.016605439,
-0.025331696,
0.0026420797,
0.011919612,
-0.02069293,
0.004951379,
-0.004114384,
-0.026393907,
-0.011926334,
-0.052384444,
0.009983432,
0.0064404896,
0.09987465,
-0.02172825,
0.017102929,
0.022481209,
0.008901052,
0.008551464,
0.0200072,
-0.03477058,
0.03673365,
-0.0103397425,
-0.00037311815,
0.005660639,
0.0072203404,
-0.003522773,
0.013748227,
0.020208886,
-0.0025866162,
0.0058556017,
-0.012753245,
0.013512927,
0.0017109652,
-0.008322887,
0.010790173,
0.014978508,
0.012134743,
-0.025398925,
0.025493044,
0.014978508,
-0.0029294817,
-0.031839415,
0.018353378,
-0.0019008857,
-0.0029429274,
0.023234168,
-0.017560083,
-0.009781746,
-0.002675694,
0.006729572,
-0.0006500155,
-0.015449108,
0.015381879,
0.0001993745,
-0.010978413,
-0.0036505072,
0.014252441,
0.0048001143,
0.017277723,
0.00717328,
-0.018837424,
-0.01597349,
0.03210833,
-0.005627025,
-0.0025210686,
-0.025667839,
-0.0011260773,
0.015139856,
-0.017667647,
0.008423731,
0.010259069,
-0.03713702,
-0.035846233,
-0.023449298,
0.0041177454,
-0.02435016,
-0.045473352,
-0.03576556,
-0.015919708,
-0.006258973,
-0.012766691,
-0.0010109484,
0.000076787546,
-0.025775405,
-0.01963072,
0.018783642,
-0.0041412753,
-0.007543037,
0.010413693,
0.0175063,
-0.0026605676,
0.0044572493,
0.0006655621,
-0.010440585,
-0.027940162,
-0.031140238,
-0.006853945,
-0.002979903,
-0.010467476,
-0.006820331,
-0.023704767,
-0.018635739,
0.009371652,
0.0064068753,
0.03151672,
0.0016101224,
-0.020585366,
0.012020455,
0.013526373,
-0.0100036,
-0.014467572,
-0.014158321,
-0.0039295056,
-0.016296187,
-0.011879275,
-0.0017260916,
0.0055429894,
-0.0025967006,
-0.010763282,
0.011334724,
-0.0097615775,
-0.03347979,
0.012242309,
-0.038212676,
0.008921221,
-0.0009411989,
0.011186821,
0.031194022,
0.033049528,
-0.0008584238,
0.008961558,
-0.016282741,
-0.03192009,
0.0041446364,
0.0081413705,
0.013822178,
-0.03057552,
0.01472304,
0.00010184066,
0.004732886,
-0.014938171,
0.0010151502,
0.018904652,
0.016403753,
0.0020252583,
0.01578525,
-0.024605628,
-0.00022395492,
-0.002161396,
0.0029126746,
0.008228768,
-0.057601374,
0.025358588,
-0.02557372,
0.03079065,
-0.011274219,
0.0042488407,
-0.026998963,
-0.00608754,
0.00007967627,
-0.0315705,
0.02347619,
0.010897739,
0.009358207,
0.0015941557,
-0.009990154,
-0.009808637,
-0.008927944,
-0.024363605,
0.022198848,
0.01144229,
0.032404132,
0.027590575,
-0.023597201,
-0.011637252,
0.02569473,
0.024081247,
0.011865829,
-0.013217122,
0.028612446,
-0.022427425,
0.006541332,
0.008430453,
0.0016723088,
-0.0067329337,
0.013062497,
-0.02100218,
-0.017640756,
0.0034790745,
-0.04832384,
-0.018272705,
-0.038831178,
-0.012074238,
0.016591992,
0.0077985055,
0.031731848,
-0.046441443,
0.0025832548,
0.032888178,
0.0041513597,
0.030709976,
-0.017560083,
0.009492664,
0.0037345428,
-0.0037513499,
0.0051328954,
0.038212676,
-0.026958626,
-0.002489135,
-0.012195249,
0.012820474,
0.0064169597,
0.030306606,
-0.0035563873,
0.02675694,
-0.0008975004,
-0.0042152265,
0.017183604,
-0.022696339,
-0.0007907752,
0.010763282,
-0.018810533,
-0.030333497,
-0.015919708,
-0.018434053,
-0.013983526,
0.009660735,
-0.009775023,
-0.00016061307,
0.017990345,
0.008558188,
-0.0032051185,
0.0059866975,
-0.03498571,
0.01972484,
-0.017654203,
0.02404091,
0.03522773,
0.014117984,
-0.02685106,
0.0017101248,
-0.005200124,
0.0071262205,
0.008934666,
0.025264468,
-0.011670867,
-0.03385627,
0.030629301,
0.031839415,
0.0070388233,
-0.048458297,
0.054535754,
-0.0015891135,
-0.011529687,
-0.019334914,
-0.026461136,
-0.020652594,
0.02201061,
0.035738666,
0.0049412944,
0.0022504737,
-0.022992145,
-0.009896034,
-0.002653845,
0.0006689235,
0.030172149,
0.005680808,
-0.0042152265,
-0.0034370567,
-0.03057552,
-0.018353378,
0.007684217,
-0.020773605,
0.00013718815,
-0.011361616,
0.010776727,
0.014386898,
0.008369948,
0.018393716,
0.032780614,
-0.0044034664,
0.025815742,
-0.008853992,
-0.010575042,
0.016981918,
0.0005453912,
0.012591897,
0.010985136,
-0.00049539,
-0.0034168882,
-0.036894996,
0.00036702555,
0.0038017714,
0.0030488123,
-0.013109556,
0.0081144795,
-0.005479122,
0.008786764,
0.015126411,
-0.0035664716,
0.017936561,
0.0045681763,
-0.0072405087,
-0.0021899682,
-0.020652594,
-0.023933344,
0.00086556684,
0.002442075,
-0.009317869,
0.020908061,
-0.016309632,
-0.005462315,
0.0010613699,
0.009459049,
0.010467476,
0.0033210877,
-0.004447165,
-0.00990948,
0.036410954,
0.009539723,
-0.016309632,
-0.00764388,
0.03022593,
0.052465115,
0.0106960535,
-0.022306414,
0.010043937,
-0.001658863,
0.0051295343,
-0.013196954,
-0.022494653,
0.04980287,
-0.007213617,
0.016403753,
0.0013092749,
-0.02941919,
0.019308023,
-0.003353021,
0.02213162,
0.008887607,
-0.049775977,
-0.04708684,
-0.0046622963,
0.008053973,
-0.010380079,
-0.0019244156,
-0.0100641055,
-0.0031160407,
-0.009001895,
-0.0013832262,
-0.016148284,
-0.0035765558,
-0.000035189914,
-0.0066925967,
0.004020264,
0.022992145,
-0.019523155,
-0.00787918,
0.0068304148,
-0.04084803,
-0.05079785,
0.0034269725,
-0.03869672,
0.030333497,
0.01738529,
-0.015072628,
-0.007906071,
-0.00514298,
-0.041654773,
0.0068035237,
0.0001878196,
0.0007264879,
0.019939972,
0.028424207,
0.020908061,
0.00504886,
0.005811903,
0.014306223,
0.0019378613,
0.005983336,
0.01665922,
-0.017936561,
0.013015436,
0.016134838,
-0.018608848,
-0.0016807123,
0.03267305,
-0.0081413705,
-0.009472495,
0.014440681,
-0.010359911,
-0.012988545,
0.0017428987,
0.004279094,
-0.01885087,
0.008524573,
0.019872744,
-0.0021815647,
-0.0017428987,
0.0010874209,
-0.026003981,
-0.0150053995,
0.00033025997,
0.014602029,
0.023489635,
0.015059182,
-0.015825588,
-0.007993468,
0.0050387755,
-0.010131334,
0.02494177,
0.031382263,
-0.009062401,
-0.00091430754,
-0.0008773318,
-0.0066253683,
0.012477608,
0.0077514453,
-0.0465759,
-0.024901435,
0.016242404,
-0.008988449,
0.008201877,
-0.028101511,
-0.0037513499,
-0.021123193,
-0.0059698904,
0.016686112,
-0.0042690095,
-0.035523538,
0.013438976,
0.000552114,
-0.010541428,
0.009163244,
0.0031513358,
-0.014857497,
-0.012101129,
-0.009196858,
0.016981918,
-0.01509952,
0.009425435,
-0.0033278104,
-0.005311051,
-0.0029479694,
-0.018998772,
0.015677685,
-0.025264468,
0.0040807696,
0.19458616,
0.007623711,
0.008080865,
0.003026963,
-0.039906833,
-0.0068640294,
0.01816514,
0.00818843,
0.016847461,
-0.009438881,
0.0025967006,
0.009546446,
-0.00080464105,
0.007892625,
-0.0057480363,
-0.036437843,
-0.036410954,
-0.021835815,
-0.0136339385,
0.009533,
0.023597201,
-0.0073480746,
0.0017697901,
-0.0012907871,
0.020249221,
0.015112965,
-0.023650983,
0.022400534,
0.01738529,
-0.00967418,
-0.0067867166,
-0.007966576,
0.0057984577,
-0.012040623,
-0.009842251,
0.0047765845,
-0.024807313,
-0.012914593,
-0.0055766036,
0.024215704,
-0.01778866,
0.016336525,
-0.0068270536,
-0.038804285,
0.010111165,
0.036115147,
-0.0057883733,
-0.01616173,
-0.025681285,
0.020988736,
-0.023825778,
-0.03928833,
-0.010548151,
0.027456118,
-0.006820331,
-0.0016101224,
0.014776823,
-0.010178394,
0.0007176642,
0.0100641055,
-0.006783355,
0.013412084,
-0.015946599,
0.015704576,
-0.00986242,
0.03272683,
-0.001425244,
0.008403562,
0.0027782174,
-0.011133038,
0.023852669,
-0.013176785,
-0.0220375,
0.0063631767,
-0.031086456,
-0.018299596,
0.022104729,
0.03600758,
-0.010218731,
0.006413598,
-0.0052438225,
0.012121297,
0.0073884116,
0.031973872,
-0.029257841,
-0.004820283,
0.011106147,
0.009754854,
-0.039369006,
0.0017865972,
-0.0036841214,
-0.00081850693,
-0.024390498,
0.0032740277,
-0.0014731444,
0.0027244347,
-0.005714422,
0.010124611,
0.00927081,
-0.017976899,
-0.019079447,
0.07750101,
0.011872552,
0.011375061,
-0.021499673,
0.008060697,
-0.011348169,
0.013499482,
-0.0155835645,
-0.017640756,
-0.00028908253,
-0.014386898,
0.012181803,
-0.009102738,
0.016605439,
0.026649375,
-0.012235586,
-0.02057192,
0.021445889,
-0.02963432,
-0.0030572158,
-0.024632521,
0.0019143313,
0.023624092,
-0.020128211,
-0.027563682,
-0.015704576,
0.018124802,
-0.006497634,
-0.028720012,
0.01903911,
-0.018702967,
0.0045681763,
-0.002448798,
-0.008195153,
-0.031032672,
-0.0017428987,
-0.007986745,
-0.0120339,
0.001300031,
-0.013902852,
-0.0011269177,
0.028155293,
-0.0142927775,
0.025640948,
-0.030091474,
0.02713342,
0.007085883,
0.0038824456,
-0.004406828,
-0.0012596939,
-0.02231986,
0.016524764,
-0.010628825,
0.026743494,
-0.016578546,
0.0010622102,
-0.021055965,
0.00967418,
0.008309442,
-0.008121202,
0.0038488312,
0.046306986,
-0.025761958,
-0.013983526,
0.012833919,
-0.17102928,
0.0170357,
0.0142658865,
-0.017304614,
0.039207656,
-0.021244204,
0.019563492,
0.00009217657,
-0.0011260773,
-0.0077312766,
0.014736486,
-0.00059665286,
-0.025761958,
-0.0200072,
0.016928134,
0.008013637,
-0.014588583,
0.017452518,
0.011758263,
-0.0039933724,
0.02531825,
-0.019388698,
0.007906071,
-0.013781841,
0.008423731,
0.020208886,
-0.028773796,
-0.021311432,
-0.006709404,
0.0030874687,
-0.0021429083,
0.010964967,
0.027160311,
0.007973299,
0.009996877,
0.007959854,
-0.00368076,
0.008511127,
-0.011294387,
0.03200076,
0.034743685,
0.01319023,
0.008638862,
-0.0104473075,
-0.021835815,
0.007085883,
0.01981896,
-0.001974837,
0.028720012,
-0.029553646,
0.02788638,
-0.014776823,
0.009808637,
0.00021397568,
0.032941964,
0.011287664,
0.008692645,
-0.0016529806,
0.028370425,
-0.02753679,
-0.004984993,
-0.024403943,
0.0061850213,
-0.009976708,
0.00046303624,
-0.032484807,
-0.03235035,
0.008591802,
0.0024202259,
0.009963263,
-0.03477058,
-0.012612065,
-0.021405552,
-0.030952,
0.015839033,
0.002821916,
-0.019550046,
0.0010865806,
0.00745564,
0.029983908,
0.010655716,
0.011617084,
0.00090002146,
-0.0038084942,
-0.015543228,
-0.0067396564,
0.010259069,
-0.0039765653,
0.0061715757,
-0.021822369,
0.009001895,
-0.014212104,
-0.00018130684,
-0.010911184,
-0.010837234,
0.022077838,
0.00792624,
0.0014328073,
0.0071531115,
-0.014709595,
0.008161539,
-0.0075026997,
-0.03347979,
0.012148188,
-0.013123002,
-0.000743295,
0.0012680974,
0.005566519,
0.026568701,
-0.0011454055,
0.002139547,
0.008060697,
0.021768587,
0.021244204,
-0.038266458,
0.021876153,
-0.019509709,
-0.0047059944,
-0.0032404135,
0.0005197603,
0.034905035,
0.0072472314,
-0.000028887243,
0.003949674,
-0.026676266,
-0.041439645,
-0.103854574,
0.0055429894,
0.008067419,
-0.01672645,
0.0048639816,
0.013129725,
0.004111022,
-0.0036236157,
-0.018581955,
0.016672667,
-0.021499673,
-0.024901435,
-0.015933152,
0.003926144,
0.018555064,
0.020827387,
-0.019052556,
-0.019792069,
0.005966529,
0.015314651,
-0.004732886,
-0.012396934,
-0.003973204,
0.002803428,
-0.013761673,
0.0022571967,
-0.0073884116,
0.03291507,
0.013627215,
0.01587937,
-0.0081413705,
-0.024511509,
0.019617274,
-0.029311623,
-0.04923815,
0.024995554,
-0.01394319,
-0.0046421275,
0.011099424,
-0.02019544,
-0.0068909205,
0.010185117,
0.0024387136,
0.00069665525,
0.015368434,
-0.008672476,
0.024457727,
0.017775213,
0.011805324,
-0.008853992,
0.00884727,
-0.010433862,
-0.020424016,
-0.03079065,
0.012423825,
-0.00038803447,
0.009317869,
0.0061715757,
-0.00010457182,
0.0063127554,
-0.0084976815,
0.012591897,
0.0073547973,
0.00025420776,
0.033022635,
0.01885087,
-0.013875961,
0.0016706281,
0.02300559,
-0.011455735,
0.015704576,
-0.008954835,
-0.02472664,
-0.0087464275,
-0.005795096,
0.010346465,
0.006632091,
-0.022696339,
0.013149894,
-0.0061144317,
-0.0076573254,
-0.009633843,
0.004043794,
0.013257459,
0.03963792,
0.010373357,
0.013929744,
-0.021418998,
0.033049528,
-0.0048169214,
0.0031731848,
0.0077783368,
-0.0052236537,
-0.0127263535,
0.004598429,
0.022104729,
0.0200072,
-0.02673005,
-0.0043261535,
0.032995746,
-0.0059698904,
-0.020356787,
-0.07163868,
0.016860906,
-0.0016874352,
0.0024756894,
-0.009096015,
-0.018487835,
0.021338323,
-0.017748322,
0.010077551,
0.008853992,
-0.04154721,
0.017304614,
-0.0406329,
0.006877475,
-0.016887797,
-0.044908635,
0.042246386,
0.019187013,
0.013123002,
-0.0021160168,
-0.009795192,
0.024175366,
0.012934762,
0.015516336,
0.0053547495,
0.030037692,
-0.0078052282,
0.003959758,
0.015381879,
0.020531582,
0.011287664,
-0.020410571,
0.012047346,
-0.0058421562,
-0.01672645,
-0.010891016,
0.010440585,
0.013573433,
0.011933058,
0.036814325,
-0.016013827,
-0.021136638,
0.0054656765,
-0.010527982,
-0.0045312005,
-0.021876153,
-0.016430644,
0.028585555,
0.0077648913,
-0.022158511,
0.022750122,
0.0030790651,
-0.035200838,
-0.008840547,
-0.0018975242,
0.0013370067,
0.012141466,
0.01838027,
-0.0057413136,
-0.021445889,
0.023140047,
-0.022252632,
0.0033412562,
0.012154912,
0.041036274,
-0.0018017236,
-0.024874542,
0.02147278,
0.03175874,
-0.00071598345,
-0.031005781,
-0.028155293,
-0.0076573254,
0.009055678,
0.0007962375,
-0.022481209,
-0.0028908253,
0.025869524,
-0.008484236,
-0.012591897,
-0.012074238,
-0.009398543,
-0.0029950293,
0.028558664,
0.017197048,
0.014023864,
-0.020625701,
0.01120699,
0.0015739871,
-0.016457535,
-0.033721812,
0.021029074,
-0.006151407,
0.016390307,
0.0081144795,
0.025815742,
0.0028387231,
0.0061547686,
0.012383489,
0.029580537,
0.009008618,
-0.0046488503,
0.009136353,
-0.009351484,
-0.0023042567,
0.004090854,
-0.023368625,
-0.03654541,
-0.0014277651,
-0.012094406,
-0.009526278,
0.012060792,
0.017869333,
0.0028639338,
-0.041681666,
0.00646402,
-0.0030572158,
0.0058959387,
-0.034958817,
0.029795669,
0.007980023,
0.018501282,
0.018729858,
-0.020625701,
0.02328795,
0.010709499,
0.015906261,
-0.038347133,
0.008578355,
-0.0041513597,
-0.013143171,
-0.013479313,
-0.021486226,
0.0017260916,
-0.0010630506,
-0.013580156,
0.017869333,
0.00972124,
-0.03713702,
0.059591338,
0.00004627211,
-0.014360006,
0.012148188,
0.0068270536,
0.0006294268,
-0.0073346286,
0.0142927775,
-0.028935144,
-0.010406971,
0.021513117,
-0.015462553,
0.021392107,
-0.022548437,
-0.03159739,
0.008981727,
-0.003838747,
0.028988926,
0.010568319,
-0.029338514,
0.034582336,
-0.0145348,
0.010527982,
0.016780231,
-0.0017160074,
0.02281735,
0.019213904,
-0.016793678,
-0.013028882,
-0.05160459,
-0.006151407,
0.036518518,
-0.015839033,
-0.011939781,
-0.0006823692,
-0.029096492,
-0.0106960535,
-0.0056371093,
0.017573528,
0.024471171,
0.0054421467,
0.019576937,
-0.028182184,
-0.006648898,
-0.00073993363,
-0.013721336,
-0.049668413,
-0.0063295625,
-0.017855888
] |
OBJECTIVE To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergic disease reduces immunoglobulin E associated eczema or food allergy at 1 year of age. DESIGN Follow-up of infants at high hereditary risk of allergic disease in the Docosahexaenoic Acid to Optimise Mother Infant Outcome (DOMInO) randomised controlled trial. SETTING Adelaide, South Australia. PARTICIPANTS 706 infants at high hereditary risk of developing allergic disease whose mothers were participating in the DOMInO trial. INTERVENTIONS | [
-0.0049461448,
0.00947364,
-0.008352739,
-0.044160802,
-0.029224457,
0.012627018,
-0.033491984,
0.009041485,
-0.018960783,
-0.015084897,
0.0048414823,
0.0017505639,
-0.008953704,
0.009676212,
-0.019865608,
0.026564004,
0.04172993,
-0.0073466287,
-0.0042000026,
0.010986181,
-0.00039185115,
-0.00066300284,
0.009082,
-0.019446958,
-0.0019835222,
-0.011222515,
0.01405853,
-0.04167591,
-0.034329284,
-0.007866564,
0.027846964,
0.0037712243,
0.014882325,
-0.009129266,
-0.0036395523,
-0.008616083,
0.001200242,
-0.00074403186,
0.012525732,
-0.012444703,
0.018596154,
0.0077517736,
0.0036935715,
-0.0030571565,
0.0011209011,
-0.01492284,
-0.00574293,
-0.0067625446,
-0.011533126,
0.0077787833,
0.0012314719,
0.012005796,
0.0108308755,
-0.0026807091,
-0.021985866,
0.010020586,
0.005580872,
-0.012681037,
-0.0057834443,
-0.018353067,
-0.0010508448,
0.01858265,
-0.019960143,
-0.011418335,
-0.015881682,
0.018299047,
-0.010709331,
0.034221243,
-0.007130551,
-0.0036091662,
0.012140844,
0.035085555,
-0.018933775,
-0.0173267,
0.010864638,
0.018393582,
-0.026955646,
-0.021391654,
0.0071373037,
0.0066680107,
0.010918656,
0.0028022525,
-0.013754671,
0.018933775,
0.007677497,
-0.00844052,
-0.0074749244,
0.029089408,
-0.017569786,
-0.027576867,
0.0019767699,
0.012478465,
0.030601948,
0.0013876215,
0.0044093276,
0.008764636,
-0.0023903553,
0.018285543,
-0.018434096,
-0.006948236,
-0.015935702,
-0.004378942,
-0.0019227505,
-0.009615441,
-0.012167853,
-0.02079744,
-0.012694542,
0.0027651144,
0.020014161,
-0.014018016,
-0.015787149,
0.037840538,
0.006634249,
-0.024727348,
0.020770432,
-0.017974932,
0.014679752,
0.0036766906,
-0.009021228,
-0.006117689,
0.0034943754,
0.014625733,
0.016570428,
-0.0007875005,
0.0010744781,
0.010756599,
-0.025200017,
-0.01609776,
-0.010391968,
-0.006586982,
0.015517052,
0.007562706,
0.018015446,
0.004871868,
-0.023822524,
0.018798726,
-0.026064325,
-0.024443746,
-0.025308056,
-0.005928621,
0.023930563,
0.038245685,
-0.01123602,
0.014976859,
-0.016300332,
0.035787806,
0.02090548,
0.02560516,
-0.0071373037,
-0.009379106,
0.0006524522,
-0.0044565946,
0.0025456608,
0.010533769,
0.01769133,
0.032303557,
0.0061784605,
0.018704193,
-0.029359505,
-0.00020320552,
-0.0021000013,
-0.031574298,
-0.016246313,
0.02009519,
0.005192608,
0.01724567,
0.024592299,
-0.017394224,
0.018758211,
-0.004395823,
0.0005258444,
0.016529914,
-0.02560516,
0.009730232,
0.005408685,
0.017839883,
0.0015724689,
0.013457566,
-0.0044397134,
-0.019960143,
-0.0086363405,
0.010999686,
0.024605803,
-0.024133135,
-0.016030235,
-0.0110402005,
0.008872675,
0.018663678,
0.011958528,
-0.020851461,
-0.009581679,
0.021283615,
-0.01039872,
-0.033140857,
-0.6495284,
0.0032732338,
0.017974932,
-0.0023785385,
0.021810304,
0.030412883,
0.003538266,
0.011931519,
-0.0065025766,
0.030764008,
0.01534149,
0.017785864,
0.012728305,
-0.011107724,
0.00846753,
-0.013923482,
0.005746306,
-0.01598972,
0.024835385,
-0.016786506,
-0.009000971,
-0.002125323,
0.006313509,
0.007711259,
0.03703025,
0.019055318,
0.020027665,
-0.013963996,
-0.0016847278,
0.01003409,
-0.0030284587,
0.013072677,
0.019122843,
0.023741495,
0.055855986,
-0.023417378,
-0.005368171,
0.012708047,
0.0060366597,
0.019473968,
-0.039785236,
-0.021054033,
0.030872047,
-0.003200645,
-0.00944663,
0.034221243,
0.022796156,
0.022309983,
0.024281688,
0.011560136,
0.0048752446,
-0.01243795,
-0.009190038,
-0.009304829,
0.014990363,
-0.0129173715,
0.03767848,
-0.017934417,
0.003067285,
0.012336664,
-0.0035754042,
-0.0031533784,
-0.034248255,
-0.017853389,
-0.005780068,
0.014787791,
-0.014517695,
0.025443103,
-0.009129266,
-0.0036868192,
0.013423803,
0.044430897,
0.019068822,
-0.014639238,
0.03527462,
-0.00061615795,
0.018096475,
0.029224457,
-0.03284375,
0.022012876,
-0.0009765682,
-0.010216406,
-0.009284572,
0.013700652,
0.026753072,
-0.0056112576,
-0.015638595,
0.02006818,
-0.03954215,
-0.03786755,
0.019446958,
0.033356935,
-0.005651772,
-0.0144906845,
-0.00785306,
0.002010532,
-0.012735057,
0.0031618187,
0.0028208217,
-0.009095504,
-0.0050508073,
-0.012113835,
-0.01766432,
-0.010965924,
0.020500336,
0.005418814,
-0.024808377,
0.028819311,
0.028360147,
-0.030628959,
0.0015361747,
0.009885537,
-0.009791004,
-0.02121609,
0.037381373,
-0.020270754,
-0.012485217,
-0.0059623835,
-0.014247598,
-0.03219552,
0.047050834,
0.00092001667,
0.0020223486,
0.009520907,
-0.01363988,
0.014126054,
-0.03276272,
0.0016087631,
0.017110622,
-0.01492284,
0.014207084,
0.017407728,
0.0034471084,
-0.02811706,
0.022174934,
0.014166568,
0.03786755,
0.012951134,
-0.0019126218,
-0.01690805,
-0.015206441,
-0.0018130237,
0.015530556,
-0.0104122255,
0.0007799041,
-0.020675898,
0.0004739352,
0.017070107,
-0.0011647918,
-0.0064654383,
0.0067760493,
-0.010972676,
-0.00983827,
0.03592285,
-0.009689717,
-0.007866564,
0.009014475,
-0.03627398,
-0.00012207103,
0.0006596266,
0.024605803,
0.011188753,
-0.002093249,
-0.0019902745,
-0.014328627,
-0.006188589,
-0.0013893096,
0.020419305,
-0.0006558284,
-0.02129712,
-0.008001613,
-0.037462406,
-0.022431526,
0.02218844,
-0.0032209025,
0.013167211,
-0.015219945,
-0.008926694,
-0.016340846,
0.008906437,
-0.011938271,
-0.026266899,
0.0068064355,
0.010054347,
0.03395115,
-0.0069279787,
0.014652743,
0.017043099,
0.0019835222,
0.036679123,
-0.010155634,
0.008589073,
-0.014517695,
0.019906122,
-0.014126054,
-0.026010307,
-0.0028680887,
0.0009782562,
0.0007575367,
-0.0051014503,
0.015854673,
-0.03289777,
0.029251466,
-0.013173964,
0.024740852,
-0.020149209,
-0.0046119,
-0.01766432,
0.012417693,
0.0033069958,
-0.0016172036,
0.01011512,
-0.0030774137,
0.006283123,
-0.004426209,
0.013018658,
-0.0017454996,
-0.021243101,
-0.0068266927,
0.01607075,
0.017016089,
-0.018920269,
0.022647602,
-0.0026216256,
-0.024592299,
0.0020426058,
0.011445345,
-0.0045511285,
0.0035652756,
-0.021364644,
0.008454025,
-0.021864323,
-0.038218673,
0.0069752457,
-0.0030537802,
0.013619623,
0.014315122,
-0.022255963,
0.013457566,
0.020756926,
0.019527987,
0.0038995203,
0.029116418,
0.0077787833,
0.0027516095,
-0.022039887,
0.012228626,
0.008062385,
-0.0040784595,
-0.0056348913,
-0.008643093,
0.0018805478,
-0.027590372,
-0.019527987,
-0.0008803462,
-0.010716084,
-0.004804344,
0.016894545,
0.032492626,
0.032627676,
0.032033462,
0.003342446,
0.0011335618,
0.014139559,
-0.0032158382,
-0.011100972,
-0.010108367,
0.005439071,
-0.035031535,
-0.017866893,
-0.03449134,
0.003129745,
0.015111907,
-0.031682335,
0.0036125425,
0.019865608,
0.014774286,
-0.0019446958,
0.024700338,
0.0024207411,
-0.025267541,
-0.0029136676,
0.02492992,
0.04005533,
0.0012584815,
-0.011533126,
-0.01808297,
0.023484902,
-0.001445017,
-0.0021557088,
-0.001980146,
0.016989078,
0.013936986,
-0.013423803,
-0.018461104,
-0.0013969061,
0.017826378,
-0.025996802,
0.0013521713,
-0.029062398,
0.0053479136,
-0.028333137,
-0.013477823,
-0.0011023319,
0.025969792,
0.0084270155,
-0.019582007,
-0.015449528,
0.005989393,
0.016813517,
0.007009008,
-0.023349855,
-0.008325729,
0.006867207,
0.02255307,
0.0067389114,
-0.014571714,
-0.0033238768,
0.01852863,
-0.009082,
-0.0030098895,
-0.030196805,
0.002223233,
0.011674928,
0.031601306,
0.015692614,
0.014936345,
0.036706135,
0.036436036,
0.015827663,
-0.0068064355,
-0.019176861,
0.00905499,
0.022255963,
-0.019987151,
0.00036146527,
0.0048077204,
-0.017866893,
0.0038995203,
0.022674613,
0.0039839256,
-0.016313838,
-0.016043741,
0.0074209054,
0.0053816754,
0.016178789,
0.022431526,
0.016205799,
0.015179431,
0.0036395523,
0.018758211,
0.026172364,
0.004757077,
0.0043384274,
0.0015538997,
0.0024713844,
0.011073962,
0.032519635,
-0.0011647918,
-0.008622835,
0.02132413,
-0.005209489,
0.015976217,
-0.0035618995,
0.00045241188,
0.013991006,
-0.011809976,
-0.0009006035,
0.021283615,
0.006121065,
-0.006570101,
0.028549215,
-0.005131836,
-0.006310133,
0.037570443,
-0.0109321615,
0.012579751,
-0.014355636,
0.021432169,
-0.017313195,
0.0012534172,
-0.0070967893,
-0.00014169523,
-0.031655326,
0.0026013684,
-0.013700652,
-0.003129745,
-0.0028832816,
-0.03376208,
-0.017164642,
-0.02244503,
0.010236663,
-0.027738925,
-0.012627018,
-0.013457566,
-0.011999044,
-0.017596796,
0.0038860154,
0.008035375,
0.0011901134,
0.024646318,
0.001428136,
0.020662393,
0.034275264,
-0.009115762,
-0.009845022,
-0.0010744781,
-0.018069465,
0.008879427,
0.013896472,
0.010054347,
-0.010628303,
-0.0313042,
0.0019227505,
-0.00044354933,
-0.0027684905,
0.0023414004,
0.0007837023,
-0.025173007,
0.0032225905,
0.0065160813,
0.02411963,
-0.0184476,
-0.028981369,
-0.026253393,
-0.012302902,
-0.011364317,
-0.0049258876,
-0.000096432945,
0.0001834758,
-0.019190365,
-0.021283615,
0.0104122255,
-0.011560136,
0.011789719,
-0.00905499,
-0.02168876,
-0.0063067568,
0.008285214,
0.04507913,
-0.015354994,
0.014558209,
0.011816728,
-0.010121872,
-0.012120587,
-0.013322516,
0.023079759,
0.00087697,
-0.008548559,
0.010128624,
-0.010013833,
-0.006752416,
-0.0100003285,
0.008082642,
-0.0015226698,
0.012478465,
0.003050404,
-0.009514154,
-0.021148566,
-0.0126135135,
-0.016894545,
0.013687147,
-0.020756926,
-0.013113192,
-0.006772673,
-0.023944067,
-0.015814159,
-0.018879754,
0.032600664,
-0.029602591,
0.00040451193,
0.006070422,
-0.02811706,
0.023525417,
0.0016923243,
-0.0154360235,
-0.027158218,
-0.007758526,
-0.01805596,
-0.020581365,
-0.0034487965,
-0.0121881105,
0.033518992,
0.006235856,
0.06320261,
-0.023565931,
-0.0040784595,
0.00964245,
0.014828306,
0.0021472683,
-0.0042438935,
0.017529272,
-0.009034732,
0.0010677258,
0.031385228,
0.0066173677,
-0.00017545732,
-0.020891976,
0.009385859,
0.012316407,
-0.0229177,
-0.036355007,
0.0011571953,
-0.014301617,
0.0038893917,
0.011033447,
-0.0033998415,
0.01763731,
-0.032546647,
-0.006559972,
-0.0013268498,
0.013383289,
0.02051384,
-0.01855564,
0.040676553,
-0.030466901,
0.023525417,
-0.0042438935,
-0.007292609,
0.009791004,
-0.0035618995,
0.009460134,
-0.01411255,
0.0012399124,
0.013504832,
0.036868192,
0.0104122255,
0.004399199,
0.0052871415,
0.022485545,
0.0071980753,
-0.0030132656,
-0.000044998524,
-0.02054085,
-0.006914474,
-0.012039558,
-0.001363988,
-0.029413525,
0.011816728,
-0.005418814,
-0.0014036585,
0.026496481,
-0.017043099,
-0.019109337,
-0.018177504,
-0.00584084,
0.034896486,
-0.022877185,
0.012066567,
0.028495196,
-0.00321415,
-0.02176979,
0.0069752457,
0.0011563513,
-0.0065025766,
0.038677838,
0.030250823,
-0.024052106,
-0.0051858556,
-0.010662065,
0.019933132,
-0.008973961,
-0.024443746,
0.01403152,
0.020608373,
0.014882325,
-0.001136938,
-0.031844392,
-0.0071508083,
0.0039164014,
-0.0024460626,
0.011154992,
0.0016923243,
-0.018001942,
-0.017731845,
0.021054033,
-0.034923494,
0.032222528,
-0.0037138287,
0.005391804,
0.013585861,
-0.042351153,
-0.013909977,
-0.004628781,
-0.011863995,
0.024740852,
0.020756926,
0.011026695,
0.0069347313,
0.0036598095,
0.015044383,
0.002351529,
-0.012681037,
0.040352438,
-0.0042303884,
-0.01185049,
0.03684118,
-0.011087467,
0.0042641507,
-0.020284258,
-0.011100972,
-0.022728633,
-0.045619324,
-0.017380718,
0.0065768533,
-0.02574021,
-0.021202587,
0.011607403,
-0.008751132,
0.001330226,
-0.015949206,
-0.019014804,
0.00888618,
-0.029521562,
-0.011425088,
0.023768505,
-0.013349527,
-0.0052128653,
0.011553383,
0.0002536376,
-0.013572357,
-0.004983283,
-0.038677838,
0.029278476,
0.012795828,
0.012120587,
-0.012235378,
0.013018658,
-0.021148566,
-0.0046692956,
-0.006070422,
0.00019824671,
-0.02811706,
0.0022823166,
0.0059016114,
0.004156112,
0.009399363,
-0.02129712,
0.029548572,
-0.0038353724,
0.0064283,
-0.018001942,
-0.00091664045,
0.01596271,
-0.0069752457,
-0.016300332,
0.01243795,
-0.0077990405,
0.02367397,
-0.0036564332,
0.0022468665,
-0.0015665605,
-0.040082343,
0.0024443746,
-0.0017260864,
0.0026857734,
-0.023903552,
0.011229268,
-0.022309983,
-0.007272352,
-0.011634413,
0.004608524,
0.01411255,
-0.013430555,
0.0007090037,
0.011769461,
0.017016089,
-0.00080606964,
-0.0033998415,
-0.019500978,
-0.022309983,
0.0011487547,
-0.024038602,
0.011303544,
-0.010952419,
0.036084913,
0.016570428,
-0.03681417,
-0.018569143,
0.004068331,
-0.03703025,
-0.011897757,
-0.01567911,
-0.0064350525,
0.0055133477,
-0.00006762967,
0.012485217,
0.028738283,
-0.018042456,
0.018879754,
-0.011377821,
-0.031709347,
0.021675255,
-0.036084913,
0.04021739,
-0.0065971105,
-0.026226385,
0.011614156,
0.016867535,
0.003588909,
-0.009095504,
0.014126054,
0.004378942,
0.0005912584,
-0.027009664,
0.007954346,
-0.01813699,
-0.014072035,
-0.004497109,
-0.0061278176,
0.01168168,
0.0037914815,
0.004183122,
-0.029386515,
-0.03052092,
-0.00925081,
-0.00050010084,
0.0014905959,
-0.030304844,
-0.0036159188,
0.0040548258,
-0.024646318,
-0.00007148065,
0.018042456,
0.0013125009,
-0.010554026,
0.0150173735,
-0.027617382,
-0.010385216,
-0.0009951373,
-0.03192542,
-0.014639238,
0.004183122,
-0.01682702,
-0.0131334495,
-0.007758526,
-0.0028630244,
-0.02205339,
-0.005037302,
-0.010236663,
-0.00014559897,
-0.019406443,
0.01964953,
-0.008447273,
-0.019122843,
-0.027441818,
0.0004903942,
-0.0045680096,
-0.016421875,
-0.01858265,
0.013936986,
-0.020918984,
-0.01347107,
0.004902254,
-0.03765147,
-0.013282002,
-0.009723479,
-0.01777236,
0.0059016114,
0.017407728,
0.18301748,
0.007866564,
-0.0069077215,
0.023268826,
-0.007893574,
-0.0014838434,
0.01850162,
0.014369141,
-0.016921554,
0.011735699,
0.03616594,
0.0027364166,
-0.012451455,
0.010655313,
0.017529272,
-0.018758211,
-0.026672043,
-0.014747277,
-0.0016686908,
-0.021837313,
0.021270111,
-0.003470742,
0.003084166,
0.0022705,
0.040379446,
-0.004963026,
-0.014072035,
0.027900983,
0.008899684,
0.014463675,
0.0015176055,
-0.0001477091,
0.01886625,
0.0027009663,
0.025591657,
-0.0022856928,
0.017286185,
-0.029224457,
0.01204631,
-0.002792124,
0.0002823354,
-0.013322516,
-0.02900838,
-0.0032310311,
-0.021445673,
0.031466257,
0.0054762093,
-0.02054085,
-0.025362074,
0.0014391086,
-0.023093263,
0.0038725105,
-0.008879427,
0.02054085,
-0.000162269,
-0.008298719,
0.033356935,
0.017056603,
-0.004591643,
0.013882968,
-0.009622193,
0.014315122,
-0.01347107,
0.03449134,
-0.0074951816,
0.0061311936,
-0.008454025,
-0.01808297,
-0.022742137,
-0.004375566,
0.017569786,
-0.03143925,
-0.025902268,
0.024767863,
-0.001704141,
-0.020149209,
0.020176219,
0.01808297,
0.009021228,
0.023741495,
-0.003423475,
-0.011836985,
-0.037840538,
0.012147596,
-0.03540967,
-0.026955646,
0.013518337,
0.0058948593,
-0.032708704,
-0.006141322,
0.004351932,
-0.0054795854,
-0.009588431,
0.0066983965,
0.02252606,
-0.01858265,
-0.0031871404,
0.0108308755,
-0.0013260057,
0.008717369,
-0.019230882,
0.07951645,
0.0011268094,
0.027738925,
-0.017110622,
-0.007913832,
-0.008183928,
0.004817849,
-0.0066308724,
-0.00096221926,
0.019028308,
-0.028846322,
0.004659167,
-0.01729969,
-0.014274607,
0.018407086,
0.023444388,
-0.015111907,
0.014193579,
0.0023278955,
0.024038602,
-0.004237141,
-0.0069549885,
0.034464333,
-0.019933132,
0.00010582302,
-0.01889326,
0.004355308,
0.0023734742,
-0.04410678,
-0.013376536,
-0.017461747,
0.026645033,
-0.0089469515,
-0.014018016,
-0.0019683293,
0.00581383,
-0.020108694,
0.0032090857,
0.033897128,
0.0015437711,
-0.018987793,
0.013153707,
-0.013140202,
-0.0013901537,
-0.020581365,
0.012289397,
0.018245028,
-0.026874615,
0.0069212266,
-0.003909649,
-0.025213521,
0.008987466,
-0.0034977514,
0.006728783,
-0.020284258,
-0.032006454,
-0.019865608,
-0.0026536996,
-0.010790361,
-0.020527344,
0.006492448,
0.018339561,
0.005459328,
-0.006684892,
0.0006929667,
-0.17232166,
0.01492284,
0.015476538,
-0.010007081,
0.019190365,
0.014855315,
0.035814814,
0.021877827,
-0.015125412,
-0.027063683,
0.037840538,
0.012026053,
-0.035598736,
-0.026901625,
0.008980713,
0.003361015,
-0.01598972,
0.026955646,
-0.000026389813,
-0.012809333,
0.015125412,
-0.016597439,
-0.0005583404,
-0.011742451,
0.024443746,
0.04424183,
-0.017151136,
-0.013167211,
-0.00077821594,
-0.012930877,
0.012627018,
0.008089394,
0.04510614,
0.01598972,
0.0068570785,
0.0058712256,
0.0005452576,
0.014612229,
-0.0010913592,
0.021999372,
-0.0030926066,
0.015273965,
0.01347107,
-0.0073601333,
-0.013086182,
0.00470981,
0.0007047834,
-0.022431526,
0.020054676,
-0.013795186,
0.0063641523,
-0.018204514,
0.014814801,
0.012532484,
0.011749204,
0.005739554,
0.003946787,
0.019271396,
0.006002898,
-0.00015825975,
-0.013437307,
-0.026469471,
0.021013519,
0.0040987167,
0.037300345,
-0.031844392,
-0.016597439,
0.014234093,
-0.02364696,
-0.008622835,
-0.021931848,
-0.015233451,
0.0029322368,
-0.008953704,
0.019690044,
0.011911262,
-0.023917057,
0.019757569,
0.023768505,
-0.005577496,
-0.032546647,
-0.023754999,
-0.03451835,
0.0086295875,
-0.028333137,
0.013059173,
-0.01486882,
0.019568501,
0.003909649,
0.0063438946,
0.03843475,
-0.020851461,
0.0046051475,
-0.011695185,
0.009169781,
0.024713842,
-0.003020018,
0.013207726,
-0.015530556,
0.0013597677,
-0.0019159981,
-0.0377325,
-0.037975587,
0.009318334,
0.017272681,
0.003669938,
-0.024646318,
0.0070900368,
0.057584602,
-0.039974302,
0.006941484,
0.018123485,
-0.0055403574,
0.027657896,
-0.007758526,
0.015422518,
-0.015179431,
-0.009399363,
0.0071373037,
-0.012275892,
0.038866907,
0.0021202585,
0.013977502,
-0.0074546672,
-0.0081096515,
0.0076639922,
-0.1109557,
-0.024241174,
0.0035450184,
0.007272352,
-0.010979429,
0.020837955,
-0.0010398721,
-0.0006524522,
-0.009136019,
0.02216143,
0.013707405,
-0.0011774525,
-0.0053614182,
-0.0029457414,
0.043701638,
-0.0013209414,
-0.011148239,
-0.019568501,
-0.03697623,
0.03284375,
0.0048448583,
-0.0060771746,
0.008589073,
-0.0016594062,
-0.0075897155,
-0.025470113,
-0.015557567,
0.0282251,
0.009622193,
0.025078474,
-0.0007334812,
-0.019973647,
0.036355007,
-0.007961098,
-0.042756297,
-0.010992933,
0.0018113356,
-0.007009008,
0.038839895,
-0.0030723494,
0.013268498,
0.008697112,
-0.0076842494,
-0.009460134,
0.025510628,
0.0013572356,
0.003909649,
0.013558852,
0.0095749255,
-0.0066680107,
-0.026631529,
-0.021972362,
-0.021081043,
0.03378909,
0.0071170465,
-0.01729969,
0.02328233,
0.019554997,
-0.018704193,
-0.028306128,
-0.0028613363,
-0.0045815143,
-0.020000657,
0.0015952582,
0.012377178,
-0.011803223,
-0.01777236,
-0.012667532,
-0.006570101,
-0.0121881105,
-0.019919626,
-0.010797113,
0.012600008,
-0.0053749233,
-0.0108308755,
0.015152422,
-0.025443103,
-0.029386515,
-0.0020307892,
-0.020864965,
-0.012174606,
-0.015517052,
0.008447273,
0.013194221,
-0.0030402753,
0.025173007,
0.02121609,
-0.009872032,
0.0011555072,
-0.02809005,
-0.025726706,
0.012721552,
0.022350498,
-0.026226385,
-0.01305242,
0.0028967864,
-0.0045308713,
-0.01769133,
0.057692643,
0.003980549,
-0.020837955,
-0.025173007,
-0.06730808,
0.036544077,
0.002483201,
0.0032715455,
-0.0036969478,
-0.038866907,
0.013207726,
0.0023616576,
0.029278476,
0.012822838,
-0.028009022,
0.015787149,
-0.026753072,
0.007063027,
-0.013194221,
-0.0164894,
0.030736998,
0.024416737,
0.0329788,
0.023511913,
0.00983827,
0.0071440563,
-0.004848235,
0.0010398721,
-0.010587788,
0.0025912398,
-0.0043451795,
0.0025237154,
0.0015125412,
0.0018501619,
0.005908364,
-0.026928635,
-0.005844216,
0.02696915,
-0.027036674,
-0.02079744,
-0.00084194186,
0.014652743,
0.023417378,
0.007501934,
-0.0048144725,
-0.02370098,
-0.003683443,
0.007873317,
-0.00022873809,
-0.010074604,
-0.04524119,
0.01567911,
0.008345986,
-0.01087139,
0.03292478,
0.021810304,
0.024821881,
-0.016556924,
0.0033593269,
0.007414153,
0.0027955002,
0.016678467,
-0.0020307892,
-0.0048617395,
0.009527659,
-0.012755314,
0.012005796,
0.011958528,
0.017448243,
-0.004949521,
-0.001136094,
0.006002898,
0.017947922,
-0.011593899,
-0.031871404,
0.001152975,
-0.01721866,
0.00020499913,
0.0008845665,
-0.013099687,
0.009770746,
0.017475253,
-0.011809976,
0.023336349,
-0.01609776,
-0.003909649,
-0.01850162,
0.019028308,
0.014315122,
0.009520907,
0.0056112576,
0.0035754042,
-0.0025878635,
0.0068908404,
-0.010662065,
0.019960143,
0.0029170436,
-0.0024899533,
0.0035720281,
0.0144906845,
0.026793586,
-0.018353067,
-0.004335051,
0.0042709033,
0.0034606133,
0.007191323,
0.010432483,
-0.029521562,
-0.0058982354,
0.010608045,
-0.02213442,
-0.0564502,
-0.010466245,
-0.007758526,
-0.00076386705,
0.0019446958,
0.013565604,
0.01288361,
-0.02258008,
0.022296477,
-0.0065127052,
0.023457894,
-0.02160773,
0.027320275,
-0.0150173735,
0.022674613,
0.01045274,
0.003310372,
0.0061480748,
0.002532156,
0.042918358,
-0.019095832,
0.049211606,
0.015071393,
0.011391326,
0.0044565946,
-0.011114477,
-0.0035348898,
0.0075221914,
-0.019690044,
0.024983939,
0.019622521,
-0.01970355,
0.08448623,
0.004135855,
-0.039650187,
-0.0014517695,
0.0056720297,
0.01609776,
-0.006360776,
0.013747919,
0.012451455,
0.00060602935,
0.004206755,
-0.016840525,
0.02411963,
-0.033140857,
-0.025726706,
-0.0032394717,
-0.007110294,
0.013896472,
-0.003588909,
-0.023106767,
0.024052106,
-0.017920911,
0.0021928472,
0.02252606,
-0.040001314,
-0.002824198,
0.016732488,
-0.02411963,
-0.009953061,
-0.026293907,
-0.015422518,
0.024281688,
-0.034842465,
-0.015179431,
0.0088389125,
-0.025200017,
-0.0027971882,
-0.0019852102,
0.012822838,
-0.009291325,
0.0023819148,
0.019325415,
-0.0066713872,
0.005597753,
0.010486502,
-0.03697623,
-0.019028308,
0.006347271,
-0.023944067
] |
SUMMARY ModLoop is a web server for automated modeling of loops in protein structures. The input is the atomic coordinates of the protein structure in the Protein Data Bank format, and the specification of the starting and ending residues of one or more segments to be modeled, containing no more than 20 residues in total. The output is the coordinates of the non-hydrogen atoms in the modeled segments. A user provides the input to the server via a simple web interface, and receives the output by e-mail. The server relies on the loop modeling routine in MODELLER that predicts the loop conformations by satisfaction of spatial restraints, without relying | [
-0.022978364,
-0.012568238,
-0.029853888,
-0.02712858,
-0.020156216,
0.030462587,
-0.015687818,
0.013515871,
0.0014767853,
-0.0038839106,
-0.0130109275,
0.013896307,
-0.01081823,
0.024085088,
-0.0028532736,
-0.005786093,
0.006114652,
-0.025343986,
-0.010230283,
0.008079087,
0.00260599,
-0.0024797542,
0.014442752,
-0.034336124,
0.013785635,
0.01521746,
-0.0008827856,
-0.026602887,
0.004547945,
0.0059036827,
0.00051920937,
0.006284119,
-0.010852816,
-0.020930924,
0.016130507,
0.021373613,
0.012187801,
0.0142214075,
0.0016964009,
-0.021249106,
0.022577176,
-0.0049871765,
-0.0072421273,
-0.0052984427,
-0.009593916,
0.018855816,
0.022909194,
-0.010666056,
-0.01586766,
-0.0061250273,
0.0003748164,
0.04230454,
-0.016089005,
-0.003825116,
0.01756925,
-0.008279681,
-0.0076363976,
-0.008618616,
0.0065953853,
-0.03538751,
0.019436846,
0.017057389,
-0.03334007,
0.009102807,
-0.007338966,
-0.010430877,
-0.003973832,
0.023158206,
-0.0038493255,
-0.020446733,
0.039703734,
0.009448659,
-0.005125517,
-0.0024797542,
0.023808407,
-0.0025904267,
-0.007996083,
0.005367613,
-0.018177947,
0.012236221,
0.009420991,
0.005568207,
0.00096060213,
0.011385427,
0.024264932,
-0.013066264,
0.011496099,
0.014359748,
-0.007705568,
-0.016683869,
-0.0012614928,
0.033312403,
0.01756925,
0.008660118,
-0.04036777,
0.005326111,
-0.006574634,
0.03535984,
-0.005267316,
-0.002808313,
-0.028691828,
0.0029587583,
-0.023628565,
-0.006574634,
-0.040533777,
-0.0046240324,
0.027073244,
-0.024389436,
0.029466536,
0.007138372,
-0.0096492525,
0.036798585,
-0.010181864,
-0.006837481,
-0.024472442,
-0.006356748,
0.011302422,
-0.009483244,
0.012111714,
-0.0065884683,
0.015881494,
0.03917804,
0.01631035,
0.00060134905,
0.033838097,
0.0010487942,
-0.015812324,
-0.0017794052,
-0.0121463,
0.02091709,
-0.0044891504,
0.0031213085,
0.004385395,
0.0153558,
0.0041640503,
0.0242926,
-0.015480307,
-0.0032959634,
-0.013211521,
-0.027598938,
0.026423043,
0.029494204,
-0.015051451,
0.017444743,
0.0016670035,
-0.0010920257,
0.035581186,
0.017264899,
0.009808345,
0.0054298663,
0.02105543,
-0.015134455,
0.009746091,
-0.00709687,
0.0022307413,
0.026091026,
0.0047762073,
0.021456618,
-0.011136414,
-0.016946716,
0.024887463,
0.018897317,
0.011779697,
0.0033167144,
0.01395856,
0.031486306,
0.018440794,
-0.02896851,
0.0059175165,
0.012402229,
-0.0037282775,
0.01819178,
-0.04022943,
0.007843909,
-0.021276776,
0.002310287,
-0.00046430543,
0.0067060576,
-0.021456618,
-0.017278733,
-0.0034533257,
0.005004469,
-0.01009886,
0.039205708,
-0.029272858,
0.00030261994,
0.013294526,
-0.014926944,
0.012422981,
-0.004437273,
0.0152451275,
-0.0060351063,
0.028470483,
-0.008383437,
-0.6290621,
-0.0064017083,
-0.014117653,
-0.033893432,
-0.0028446272,
0.0014352831,
0.009974353,
-0.014027731,
-0.009379488,
0.021968478,
-0.013571207,
0.0038147403,
0.010071191,
-0.030241242,
-0.019907204,
-0.027806448,
-0.012955592,
-0.014830106,
-0.019533684,
0.011648273,
-0.022563342,
0.013930893,
-0.015618647,
0.026049525,
0.0010781916,
0.0048592114,
0.021484286,
-0.0063048704,
-0.0052223555,
0.002957029,
-0.00823818,
-0.011565269,
-0.006450128,
-0.0071176207,
0.04532036,
0.00063204335,
-0.001872785,
-0.0000818695,
0.014290578,
0.026755061,
-0.0032907757,
-0.018828148,
0.030462587,
-0.007664066,
-0.042027857,
0.017818261,
0.016946716,
-0.009448659,
-0.038098983,
-0.0048868796,
0.02924519,
-0.01228464,
-0.009165061,
0.0019402261,
-0.004101797,
-0.013315277,
0.013508954,
-0.0081620915,
0.018675974,
0.00902672,
0.0022445752,
-0.0051462683,
-0.019173998,
-0.010264868,
-0.016158175,
-0.027889453,
-0.008590948,
-0.000068792,
-0.0042470545,
-0.01631035,
0.012485234,
0.023642398,
0.010783645,
0.006263368,
0.01747241,
0.03541518,
-0.00046992552,
0.011371592,
0.014373582,
0.019492183,
0.017347904,
0.006903193,
-0.03594087,
-0.0065469663,
0.020626575,
0.01419374,
-0.025925018,
0.0034515965,
0.002666514,
-0.010506964,
0.032814376,
0.0011611959,
-0.0003763295,
-0.024334101,
-0.012948674,
0.02033606,
-0.031403303,
0.004087963,
-0.0092757335,
-0.03829266,
-0.014179905,
-0.025509996,
0.025081139,
-0.0128172515,
0.02515031,
0.0026855357,
-0.026810396,
-0.0030434919,
0.04003575,
-0.01298326,
-0.0040637534,
-0.0010894318,
-0.020294556,
-0.02259101,
-0.0015390385,
-0.04136382,
-0.0012390125,
-0.016130507,
-0.0067371842,
-0.01202871,
0.018579135,
-0.0023898329,
0.012748081,
-0.0011646544,
-0.028996177,
-0.008148258,
0.023268878,
-0.03732428,
-0.013612709,
-0.0030849942,
0.00091218296,
-0.0010306371,
0.027349925,
-0.022812355,
0.012671993,
0.009420991,
0.028442815,
-0.0125405695,
0.025676005,
-0.008604782,
-0.005409115,
0.0008620345,
-0.016199678,
-0.0102095315,
-0.00409488,
-0.037794635,
-0.04139149,
-0.0020872129,
0.027073244,
0.009988187,
-0.006439752,
0.010520798,
-0.006156154,
0.008763873,
-0.0034930985,
-0.0059693945,
-0.00010726796,
-0.03555352,
-0.02119377,
-0.015756987,
-0.00786466,
0.0012320954,
-0.031762987,
0.033201728,
0.0015701652,
-0.020737248,
0.006107735,
0.015369634,
-0.010776728,
-0.024444774,
-0.005637377,
-0.017583083,
-0.043355927,
0.019270837,
-0.010029689,
0.014069233,
0.0050010104,
-0.01805344,
-0.005765342,
-0.0081620915,
0.005796469,
0.004115631,
-0.0026820772,
-0.00844569,
0.0075948955,
0.041197814,
0.07271179,
0.026367707,
-0.036162216,
0.015258961,
0.040146425,
0.013322194,
-0.01414532,
0.009082057,
-0.011115663,
-0.00460674,
0.028442815,
0.0042470545,
-0.005509412,
0.015203625,
0.01828862,
0.00979451,
-0.0023050993,
-0.011094911,
-0.0029137977,
-0.020792583,
0.00054730976,
-0.03992508,
0.019215502,
-0.0025627585,
0.00024123132,
-0.006190739,
-0.025454659,
-0.0019886452,
0.02443094,
0.036051545,
0.024417106,
0.0077124853,
-0.033257067,
0.009379488,
0.008196677,
-0.0017828638,
0.026063358,
-0.014857774,
0.0023050993,
0.01900799,
0.002324121,
0.031071285,
0.001188864,
0.0057826345,
-0.0030625137,
0.017555414,
-0.0038424085,
0.0057757176,
-0.000297216,
-0.024707621,
0.006439752,
0.004008417,
0.0236839,
-0.0040983385,
-0.0014404709,
0.010970405,
0.019990208,
-0.010251034,
0.03228868,
-0.010105777,
0.041474495,
0.015549477,
-0.006367123,
-0.029328195,
-0.031928997,
0.014594927,
-0.03054559,
0.016628534,
-0.0037421116,
-0.011620605,
-0.010977322,
-0.000010544413,
0.06407934,
0.015065284,
-0.0045410283,
0.014567259,
0.0061665294,
0.003078077,
-0.0012295016,
-0.017721424,
0.014207574,
-0.032565363,
-0.013605792,
-0.014290578,
0.014117653,
0.014484255,
-0.005246565,
-0.024887463,
0.013363697,
-0.011115663,
0.01363346,
0.03541518,
0.018413126,
0.0012225845,
-0.026132528,
-0.021318277,
0.026229367,
0.008044503,
-0.0028878588,
-0.00812059,
-0.03890136,
0.018343955,
0.010500047,
0.009787593,
-0.00051186,
0.0035207667,
0.002215178,
0.011157164,
-0.024278766,
-0.0075948955,
0.013294526,
-0.033257067,
0.0142214075,
0.000033666467,
0.011011907,
0.0058033857,
0.023255045,
-0.026063358,
0.05732832,
0.012706579,
0.043687943,
-0.027944788,
0.004478775,
-0.0042263037,
-0.016766874,
-0.005004469,
0.0130109275,
-0.018841982,
-0.012139383,
0.019561352,
-0.0089921355,
0.01563248,
0.009773759,
0.008763873,
-0.0028792126,
-0.023628565,
-0.026561383,
0.029660212,
0.012346894,
0.027668107,
0.022770854,
-0.0072836294,
-0.0022705141,
-0.0054229493,
-0.03375509,
0.008175926,
0.011973374,
0.01433208,
-0.022604844,
0.0012614928,
-0.0022549508,
0.019464513,
0.020958591,
-0.014747102,
0.013986229,
-0.046427086,
-0.008604782,
-0.00025420074,
-0.007906162,
-0.00805142,
0.0053364863,
0.024168093,
0.02968788,
0.0065884683,
-0.0033979896,
0.022272827,
-0.0037490285,
-0.028719496,
0.019561352,
0.0064362935,
0.01754158,
0.024085088,
-0.006256451,
0.0052707745,
0.021069264,
-0.024043586,
0.0073112976,
0.020142382,
0.0053122765,
0.012547487,
-0.0039565396,
0.015272795,
-0.011413095,
-0.011765863,
0.000327478,
0.009310318,
0.0055716652,
-0.012976343,
-0.007657149,
0.0007613053,
-0.02272935,
-0.017320236,
-0.003925413,
0.0030677016,
-0.0049110893,
-0.035608854,
-0.0038285744,
-0.028581155,
-0.030462587,
-0.03217801,
0.035636522,
-0.0030175531,
-0.007940747,
-0.000021561671,
-0.01900799,
0.004648242,
-0.03378276,
-0.023365717,
0.02361473,
-0.025177978,
-0.031403303,
0.010071191,
0.014926944,
0.027502099,
-0.01675304,
-0.024486275,
-0.00174482,
0.01637952,
-0.022757018,
0.002687265,
0.0006030783,
-0.013882473,
0.007843909,
0.033201728,
0.0025956144,
-0.0020820252,
0.005751508,
0.030019898,
-0.0029380072,
-0.0043611857,
0.0025714047,
-0.01579849,
-0.016780708,
0.019630523,
0.00020913199,
0.03610688,
-0.009483244,
-0.031956665,
0.011835033,
-0.03569186,
-0.007961498,
-0.008272764,
0.011433845,
-0.023089036,
-0.00070683367,
0.0120702125,
-0.027253086,
-0.018482296,
0.0022272826,
0.012512902,
0.017251065,
0.016006,
-0.008459524,
0.014622595,
0.00014828377,
-0.0000058936585,
-0.017389406,
-0.025606833,
-0.013135434,
-0.018966489,
0.03347841,
0.012554404,
0.0010574405,
0.017693754,
0.012250055,
-0.005454076,
0.023794573,
-0.009559331,
-0.022023814,
0.032842044,
-0.019395344,
-0.036466565,
-0.0030970988,
-0.012658159,
-0.014857774,
0.013965477,
-0.008867629,
0.013799469,
-0.0066783894,
0.0034706183,
-0.007664066,
0.006827106,
-0.02200998,
-0.02068191,
-0.020004041,
-0.007906162,
-0.026409209,
0.023932913,
-0.0027495183,
0.024818294,
-0.00914431,
-0.015438804,
0.00015606542,
-0.03054559,
-0.009199646,
-0.027986292,
0.027031742,
0.033893432,
0.03245469,
0.007131455,
0.029936893,
-0.014020814,
-0.0033789678,
-0.0031074744,
0.015881494,
-0.01579849,
-0.024984302,
-0.02142895,
0.026063358,
-0.0029189854,
0.0066783894,
-0.026395375,
0.0060178135,
0.004285098,
0.0020457108,
-0.019851867,
0.012139383,
-0.025164144,
-0.010105777,
-0.002310287,
-0.00563046,
0.003036575,
-0.019312339,
-0.0017188812,
0.0042401375,
0.006795979,
0.008985218,
0.012090963,
0.00029959372,
-0.006377499,
0.028802501,
0.021664128,
0.023047535,
-0.004565238,
0.0043681026,
-0.030047566,
0.009234231,
0.018952655,
-0.019132497,
0.011413095,
0.0027616231,
-0.001528663,
-0.023310382,
-0.023725403,
-0.0077470704,
0.011752029,
0.009054388,
-0.003953081,
-0.000112834,
-0.018247116,
-0.016199678,
-0.030849941,
0.0144980885,
0.0016479817,
0.0018157196,
0.011717443,
-0.043798614,
-0.00946941,
0.061755218,
-0.0108597325,
0.024417106,
0.017583083,
0.032371685,
0.013785635,
0.028276807,
-0.025219481,
-0.0019454139,
-0.03184599,
0.014069233,
0.027626606,
-0.003448138,
0.007103787,
-0.017168062,
-0.0018364707,
-0.014899276,
-0.017596917,
-0.051407345,
0.01317002,
0.0022670557,
0.019851867,
-0.020211553,
0.016462523,
-0.023324216,
0.024209594,
-0.018081108,
0.022106819,
-0.016849877,
-0.01900799,
-0.02405742,
0.0144012505,
-0.009939767,
0.006989656,
-0.0050701806,
0.002747789,
0.020875588,
-0.02077875,
-0.023448722,
0.018703641,
0.03145864,
0.013668045,
0.026810396,
-0.018648304,
0.015853826,
0.011558352,
-0.011018824,
-0.008397271,
-0.0032527319,
0.04227687,
-0.012658159,
-0.004309308,
0.026367707,
0.015328132,
0.009151227,
-0.017264899,
0.0053503206,
-0.031237295,
-0.019340007,
0.015106787,
0.016988218,
0.00786466,
0.015189791,
-0.023656232,
-0.005353779,
0.0034827231,
-0.013979312,
-0.004727788,
0.010735226,
-0.047506142,
-0.032067336,
-0.028166134,
0.005907141,
0.01914633,
0.00793383,
-0.0046032816,
0.00895755,
0.04971959,
-0.03555352,
0.025136476,
0.0022601385,
0.03115429,
-0.03286971,
0.012623575,
-0.013315277,
-0.0070761186,
-0.006156154,
-0.0046032816,
-0.042166196,
-0.014456587,
-0.004790041,
0.015715485,
0.00470012,
-0.035802532,
0.03671558,
-0.005343403,
0.00909589,
-0.0005818949,
0.0035415178,
0.010520798,
-0.017181896,
0.0020872129,
-0.00014287984,
0.014968446,
0.0056339186,
0.0020284182,
-0.019602854,
-0.011523767,
-0.03375509,
-0.01689138,
0.019644357,
0.013204604,
-0.013543539,
0.0099121,
-0.03378276,
-0.039399385,
-0.021096932,
0.011745112,
-0.011053409,
0.008411105,
-0.013031679,
-0.0025679462,
0.004177884,
-0.013827137,
-0.02791712,
-0.005671962,
0.0026924529,
-0.008570196,
-0.024029752,
-0.033008054,
-0.028802501,
0.03162465,
0.0063740406,
-0.045237355,
-0.004755456,
0.024956634,
-0.05926509,
0.0011577375,
-0.037019927,
0.008037586,
0.0051981458,
0.030739268,
0.017666087,
0.025593,
-0.013495119,
0.009310318,
-0.008009917,
-0.009614668,
0.020585073,
0.0077954894,
0.026008021,
-0.011835033,
-0.043992292,
0.001400698,
-0.013695713,
0.0015900516,
-0.028442815,
0.016282681,
-0.014345914,
0.00022891036,
-0.016393354,
-0.010382458,
0.0072767125,
0.008964467,
0.022480337,
0.0025316318,
-0.0021114226,
0.013481285,
0.008113673,
-0.015397302,
0.00070726604,
0.006325621,
-0.0059451847,
-0.007871577,
-0.00022761342,
-0.0037836137,
0.0058033857,
-0.021747133,
0.002875754,
-0.011765863,
0.0000851659,
0.011274754,
-0.000440312,
0.004499526,
0.0072490443,
0.001104995,
-0.034059443,
-0.0217748,
0.021332111,
0.0236839,
-0.007484223,
0.015106787,
0.014594927,
-0.005125517,
-0.0012744622,
-0.0054402417,
-0.0017491432,
-0.026492214,
0.009607751,
0.013107766,
-0.0078093237,
0.017928934,
0.011938789,
0.006533132,
0.024306433,
0.011475348,
-0.010334038,
-0.032731373,
-0.0017517371,
-0.01682221,
-0.02272935,
0.0185653,
0.0069827386,
-0.022217492,
0.0041986355,
0.016863711,
0.18570834,
-0.019768864,
0.0036383562,
0.035221502,
0.0075118914,
0.015466472,
-0.0063740406,
0.02740526,
-0.027349925,
0.015784655,
0.011952623,
0.0025143393,
0.00066273764,
-0.0037386531,
0.02586968,
-0.008224345,
-0.021982312,
-0.01842696,
-0.021124601,
-0.010963487,
0.014117653,
-0.0036314393,
-0.01719573,
-0.026768895,
0.033727422,
0.0036314393,
-0.0034879108,
0.0089921355,
-0.0060385647,
0.03657724,
-0.0071591227,
0.007456555,
-0.0005122923,
-0.019298505,
0.010361707,
-0.0043923124,
0.00036508933,
-0.014235241,
0.014954613,
0.013391364,
-0.025676005,
-0.010375541,
0.010783645,
-0.0101196105,
0.0041813427,
-0.007179874,
0.016158175,
-0.011205584,
0.009414074,
0.010078108,
-0.014885442,
0.00646742,
0.02272935,
0.013460535,
0.0155218085,
-0.016600864,
-0.026063358,
0.009393322,
0.00060783373,
0.022369666,
-0.030019898,
-0.0017232044,
-0.013301443,
0.025689838,
-0.021207605,
-0.009580082,
0.0070069483,
0.009524746,
-0.006412084,
-0.027100911,
-0.023725403,
0.009670003,
0.000526991,
0.0098360125,
-0.02272935,
-0.01767992,
0.031126622,
0.031762987,
0.026782729,
0.022272827,
-0.023172041,
-0.01877281,
0.00096060213,
-0.017444743,
-0.017181896,
0.0028290641,
0.026284702,
-0.010562301,
-0.029770885,
0.007705568,
-0.000774707,
-0.02129061,
-0.018717475,
0.022508007,
-0.019257003,
-0.008680869,
-0.014622595,
-0.0033634044,
-0.009856763,
-0.01419374,
-0.02719775,
0.045514036,
-0.008950633,
0.008293515,
-0.00096060213,
-0.019257003,
-0.00031105007,
0.018260952,
-0.0035588103,
-0.011399261,
0.005343403,
-0.044711664,
0.01419374,
-0.0054852027,
-0.00781624,
0.01305243,
0.018994156,
-0.023019865,
0.00877079,
0.010520798,
-0.003015824,
-0.025994187,
-0.016268848,
0.0073527996,
-0.008736205,
-0.0028256055,
0.017320236,
-0.011157164,
-0.02180247,
-0.0022238242,
-0.0075879786,
0.0023829157,
0.0027996667,
0.010174947,
0.003394531,
-0.02631237,
-0.018136445,
-0.020253055,
0.004236679,
-0.0029328195,
-0.01370263,
0.020737248,
-0.007214459,
0.0102994535,
0.006232241,
-0.014539591,
0.018551467,
0.050079275,
-0.009656169,
-0.0069412366,
0.006647263,
-0.023490224,
0.01433208,
-0.025676005,
0.0044096047,
-0.022065315,
-0.012782666,
-0.00807217,
-0.01675304,
-0.022286661,
-0.028940842,
-0.0046586175,
0.0008136153,
0.0052707745,
-0.012838002,
0.0130939325,
-0.17685455,
-0.0051808534,
0.015743153,
-0.030905277,
0.010921986,
0.040533777,
0.013688796,
0.00691011,
0.002457274,
-0.011758946,
0.0009986458,
-0.0036003126,
-0.028276807,
-0.023974415,
-0.005039054,
0.010838982,
-0.002457274,
0.014207574,
0.012609741,
0.021013929,
0.016075172,
-0.04003575,
0.001528663,
0.0017949685,
0.010368624,
0.013965477,
-0.00068737956,
0.02019772,
0.011592938,
-0.024998136,
-0.005201604,
0.00697928,
0.035802532,
0.0069343196,
0.01740324,
0.010140361,
0.035774864,
-0.0010315017,
-0.0025143393,
0.019768864,
0.0035397885,
0.020031711,
-0.007387385,
0.007498057,
0.035055492,
0.027225418,
0.02528865,
-0.013508954,
0.021401282,
-0.00024858065,
0.029853888,
-0.009123558,
0.028774833,
-0.0025714047,
0.00055984687,
0.00036206315,
-0.026699724,
0.027502099,
-0.021954644,
-0.019921038,
-0.017029721,
-0.012609741,
0.006460503,
-0.0019644357,
-0.026506048,
-0.0050943904,
-0.023061369,
-0.016531695,
-0.04039544,
-0.004942216,
-0.008667035,
0.013412115,
-0.00595556,
-0.01644869,
0.014131486,
0.032150343,
-0.0009009428,
0.015922995,
0.0021373613,
-0.04125315,
-0.006540049,
0.028110798,
-0.010880483,
0.005160102,
0.014926944,
-0.008217428,
-0.0035588103,
0.0077470704,
0.002268785,
-0.0050943904,
0.02996456,
-0.011343924,
0.016434856,
-0.017666087,
0.024735289,
0.021608792,
0.024306433,
-0.004561779,
-0.0116067715,
0.021138435,
0.006923944,
0.0072974637,
0.005730757,
-0.009365655,
0.016393354,
0.0155218085,
-0.008881463,
0.009102807,
0.029438866,
-0.009434825,
-0.019118663,
-0.018745143,
0.012208553,
0.02838748,
0.0070173237,
0.027073244,
0.014677932,
-0.013744133,
-0.0030970988,
0.013301443,
0.036245223,
-0.01637952,
-0.021982312,
-0.0051635606,
-0.029217523,
-0.0099328505,
-0.09147076,
-0.02596652,
0.021387447,
0.028830169,
-0.018302454,
0.016780708,
0.010769811,
0.043328255,
-0.00010629525,
0.03569186,
-0.017638419,
-0.004748539,
-0.0060351063,
-0.0021581124,
-0.02419576,
0.0014266368,
-0.0034913693,
-0.0031264962,
-0.022549508,
0.032095004,
0.0053468617,
-0.020170052,
-0.008355768,
0.0089091305,
0.028747164,
0.019879535,
-0.014442752,
0.021581125,
0.020031711,
0.02405742,
-0.009919017,
-0.019547518,
0.0043266006,
0.0057272986,
-0.0027737278,
-0.020239221,
0.005395281,
-0.045265026,
0.03569186,
0.0035311424,
-0.015881494,
0.0009476327,
-0.0055578314,
-0.013508954,
0.028802501,
-0.010202615,
-0.012077129,
0.02938353,
-0.00823818,
0.007940747,
-0.0028342518,
-0.021899307,
-0.018897317,
-0.0028238762,
0.024845961,
0.014553425,
0.015162123,
0.010382458,
-0.01400698,
0.031126622,
-0.0077470704,
0.012111714,
-0.019796532,
-0.009891349,
0.015743153,
-0.00061042764,
-0.008687786,
-0.0017724881,
0.044213638,
-0.0037905308,
-0.016642367,
0.023130538,
-0.0072421273,
0.0007319079,
0.0051704776,
-0.008570196,
-0.025413157,
0.009967436,
0.020557404,
-0.024237262,
0.0042332206,
-0.011828116,
-0.006149237,
-0.026796563,
-0.0013626544,
0.017112724,
0.01133009,
-0.0035657275,
0.0038562426,
-0.02924519,
0.0013142352,
0.02938353,
0.026796563,
0.001912558,
0.010534632,
-0.0065469663,
-0.009538581,
-0.027515933,
-0.0019384968,
0.016172009,
-0.06457736,
-0.009600833,
-0.059154414,
0.016739205,
0.0072905463,
-0.012831085,
0.008134424,
0.003104016,
0.004783124,
0.0098360125,
0.011254003,
0.009165061,
-0.012125548,
-0.013522788,
-0.019160165,
0.0077609043,
-0.033561416,
-0.0066438043,
0.033423074,
-0.015853826,
0.02129061,
0.0018918068,
-0.0007128861,
-0.008245097,
0.0067648524,
0.011696693,
0.00021799443,
-0.020515902,
-0.019879535,
0.018551467,
-0.01624118,
-0.022674015,
-0.0065365904,
-0.02252184,
-0.02596652,
0.025482327,
-0.025537664,
-0.032731373,
0.015992166,
0.036162216,
0.025454659,
0.027239252,
-0.024652284,
-0.035276838,
-0.0026025313,
-0.008784625,
0.016711537,
-0.0037144434,
-0.020792583,
-0.015535642,
-0.015701652,
-0.010797479,
0.026257034,
0.013266858,
-0.0024192303,
-0.026727393,
-0.009462493,
0.0027512475,
0.0075118914,
-0.0013202876,
-0.006709516,
0.0075879786,
0.024278766,
0.006432835,
0.015079119,
0.00031364395,
-0.0409488,
0.0056615868,
-0.01184195,
0.006100818,
0.011807365,
-0.009497078,
-0.013363697,
0.01528663,
0.006647263,
0.0077124853,
0.010126527,
-0.020087047,
-0.010901235,
0.008300432,
-0.006097359,
0.018094942,
0.027958624,
-0.030656263,
-0.012533653,
0.033257067,
0.014290578,
-0.017859764,
-0.004679369,
0.018454628,
-0.003494828,
-0.00033785353,
0.009718423,
0.0063878745,
0.008169009,
0.016061338,
-0.0040706703,
0.011184833,
-0.0014534403,
-0.033838097,
0.012443732,
0.02552383,
0.0031368718,
0.008507943,
0.00061085995,
-0.042747226,
-0.02634004,
0.019270837,
-0.022092985,
-0.010714475,
0.0028031252,
0.010361707,
0.0281523,
-0.021553457,
-0.008618616,
0.00658501,
0.0035207667,
0.026215533,
-0.009538581,
0.0046344083,
-0.015826158,
0.011454597,
0.014567259,
0.0029293608,
0.011475348,
-0.013398281,
-0.0061526955,
0.044351976,
0.023863744,
-0.03228868,
0.011835033,
-0.017002052,
-0.018689808,
-0.009040554,
-0.0141245695,
-0.03535984,
-0.014581093,
0.009116641,
-0.00047597793,
0.002659597,
-0.0099328505,
0.096174344,
0.034640472,
0.01030637,
0.0047312463,
-0.012381478,
0.026699724,
0.012090963,
0.025745174,
-0.008494109,
-0.030656263,
-0.0035207667,
-0.012907173,
-0.032150343,
-0.03699226,
-0.016421022,
0.012810334,
0.0072905463,
0.025855847,
-0.021138435,
-0.0018814313,
0.03057326,
-0.030241242,
-0.016365686,
0.005460993,
-0.017029721,
0.013799469,
0.014290578,
0.0051877704,
0.008916047,
-0.013204604,
0.018260952,
0.02456928,
-0.01709889,
-0.025302485,
0.004897255,
0.0153558,
0.004499526,
-0.017901266,
0.006508922,
0.008750039,
-0.02443094,
0.010755977,
-0.032731373,
-0.00016481978,
-0.022743184,
0.023891412,
0.014885442,
-0.007705568,
-0.026589053
] |
Informal carers in cancer and palliative care are known to have high needs and psychological morbidity, yet a literature review identified few targeted interventions. This systematic review of interventions for carers of patients using home cancer and palliative care services searched Medline, CancerLit, Psycinfo and Cinahl databases. The terms used were carer(s), caregiver(s), palliative and cancer. Papers that reported interventions for adults actively providing informal care for noninstitutionalized cancer and palliative care patients were reviewed. Twenty-two interventions were identified, comprising home nursing care (four), respite services (three), social networks and activity enhancement ( | [
0.004563281,
0.0013564731,
0.017897543,
-0.029895086,
0.010562053,
0.018213615,
0.0012955635,
0.0075396197,
-0.009640178,
-0.012781137,
-0.023455132,
0.0148948645,
-0.0034076448,
0.027366515,
-0.02315223,
0.003908091,
0.045277227,
-0.00073996925,
-0.0055872207,
-0.01945156,
-0.035083923,
0.00860636,
0.0036446983,
0.024719417,
-0.022664953,
0.016672766,
0.011306137,
-0.027392855,
0.013986159,
-0.029710712,
-0.00024137483,
-0.027076783,
0.0018338726,
-0.032476336,
-0.025654461,
-0.008678794,
0.008757812,
-0.012412387,
0.018635042,
-0.031343747,
0.0014256136,
0.00084532634,
-0.004820089,
-0.007058928,
-0.015026561,
0.020320756,
-0.0044315844,
-0.011589285,
-0.022335712,
0.029658033,
0.008257365,
0.015250445,
-0.025127675,
-0.00086672703,
-0.004345982,
-0.019833481,
-0.012458481,
0.04698928,
0.033161156,
0.0099628335,
-0.02133482,
0.011253458,
-0.014170534,
0.038718745,
-0.015026561,
0.019728122,
0.0026355744,
-0.0012288921,
0.011385155,
0.011115178,
0.04480312,
0.025535936,
-0.01506607,
0.014394418,
0.012175334,
-0.01468415,
-0.006946986,
0.0046752226,
-0.0043130578,
0.014815846,
0.006071205,
-0.026629016,
-0.025865177,
0.0064794635,
0.015342632,
0.01833214,
-0.012530914,
0.015395311,
0.024495533,
-0.001347419,
0.0030372485,
0.024311159,
0.01833214,
0.014934373,
0.013182811,
0.039561603,
0.0077832583,
0.0337933,
0.0025203403,
-0.03721741,
-0.021835266,
0.026036382,
-0.020465624,
-0.005392968,
-0.016277676,
-0.03239732,
-0.0078095975,
0.009291182,
0.016975667,
0.00076795474,
-0.026655354,
0.032133926,
-0.007460602,
-0.018924775,
0.029921426,
-0.00865904,
0.0046883924,
-0.0019128905,
-0.029974105,
-0.025878346,
0.0019787387,
-0.0074737715,
0.03418839,
0.0071774544,
0.022520088,
-0.011931695,
-0.010713504,
0.0001977504,
-0.023534149,
-0.019333033,
-0.03308214,
0.018911606,
0.004444754,
-0.005646484,
-0.026312944,
0.004089174,
0.014473436,
-0.015500668,
-0.019780802,
-0.043117408,
0.0054028453,
0.034451783,
-0.0016634903,
-0.011121762,
-0.030474551,
0.015922097,
0.027287498,
0.009607254,
-0.027998658,
-0.0059559704,
0.015382141,
0.00049674243,
-0.009857477,
-0.013018191,
-0.0053238277,
-0.015092409,
-0.0010041852,
0.016593749,
-0.0374808,
-0.007098437,
0.015895758,
-0.00826395,
0.008270535,
0.01575089,
0.001091434,
0.002526925,
0.0072169635,
0.0049880017,
-0.016672766,
-0.009317521,
-0.007631807,
0.038349997,
-0.010924217,
0.016001115,
-0.033872318,
-0.005857198,
-0.012195088,
0.018990623,
-0.006683593,
-0.03308214,
-0.02460089,
0.018858926,
0.005679408,
0.028104015,
-0.0113324765,
-0.034214728,
0.011530021,
-0.022967855,
-0.0024116905,
-0.017779017,
0.02865714,
0.040325444,
0.0056366064,
-0.028024998,
-0.6304571,
-0.015197766,
0.017383927,
-0.02136116,
0.0017186382,
0.036558926,
0.005333705,
-0.013696427,
-0.034214728,
0.042142853,
0.00108238,
0.03200223,
-0.0012165456,
0.013064285,
-0.013801784,
-0.026405131,
-0.026931917,
-0.0075857136,
0.02240156,
-0.014368079,
0.01614598,
0.045224547,
-0.014196874,
-0.012748213,
-0.0070720976,
0.015948435,
0.013498883,
-0.020333927,
0.014934373,
0.035162944,
-0.0037335933,
0.03273973,
-0.020518301,
-0.002671791,
0.044592407,
0.008448325,
-0.009692856,
0.038982138,
-0.0045929123,
0.029816069,
-0.0043920754,
0.00057864113,
0.017515624,
0.000549421,
-0.046567854,
-0.01430223,
0.0076186378,
-0.014460267,
0.008566852,
-0.008257365,
0.023692185,
-0.0072630574,
-0.030948658,
-0.02458772,
0.02088705,
-0.016830802,
0.0065914057,
-0.041299995,
0.020729017,
0.018450668,
0.024390176,
0.018397989,
-0.013880802,
-0.024548212,
-0.0054654013,
0.038349997,
-0.021031918,
0.00643337,
-0.01875357,
0.012603347,
0.013156472,
0.04048348,
-0.011865847,
0.00022943984,
0.017120535,
0.017199552,
0.0093702,
0.002036356,
-0.015685042,
-0.0121885035,
0.014447097,
-0.016080132,
-0.034030356,
0.013828124,
0.040904906,
0.0014083285,
0.015171427,
0.0065025105,
0.00670664,
0.006545312,
0.009475557,
-0.002945061,
-0.01506607,
-0.016738614,
-0.020834373,
0.027392855,
0.020689506,
-0.02461406,
0.031449106,
-0.035558034,
0.0026158202,
-0.011483927,
0.015368972,
-0.0023688893,
-0.01156953,
0.0017960098,
-0.022585936,
0.009106807,
0.039113835,
0.00070004875,
0.017871203,
0.0016857141,
0.03368794,
0.0014725305,
0.025101338,
-0.026036382,
-0.0031985766,
0.013472543,
-0.017067855,
-0.04401294,
0.007137946,
0.015250445,
0.02055781,
-0.0015235629,
0.04158973,
0.011628794,
0.00094245246,
-0.024363836,
-0.011622209,
-0.02682656,
0.0033434427,
-0.037533477,
0.008474665,
0.0026569753,
0.022941515,
-0.00017933348,
0.018450668,
0.00093092903,
-0.0009877231,
-0.032871425,
-0.026378792,
0.010252566,
0.0019458146,
0.001781194,
0.0058374438,
-0.019701784,
-0.0081124995,
-0.0135252215,
0.0075791287,
0.013130133,
-0.009890401,
-0.0012634625,
-0.015698213,
0.0004080531,
0.007203794,
-0.009271428,
-0.024837945,
-0.011069084,
0.0071840393,
-0.032976784,
0.017541962,
0.020017855,
-0.016053794,
-0.0072959815,
0.009133146,
-0.01651473,
0.0016643135,
0.014670981,
0.015935266,
-0.034952227,
-0.012761382,
-0.016685937,
-0.017765846,
0.011306137,
0.012043637,
0.013406695,
0.0023853513,
0.015843078,
0.020070534,
0.018490177,
-0.014829016,
-0.011075669,
-0.008356137,
-0.009067298,
0.021532364,
0.007565959,
0.037191067,
0.016106471,
-0.014157365,
0.025430579,
-0.008046651,
0.0014346679,
0.0064893407,
0.03150178,
0.0011062499,
-0.0007551966,
-0.023086382,
0.0008593191,
0.00010484269,
0.015197766,
0.029183926,
0.0028051336,
0.027471872,
-0.008059821,
0.016330356,
-0.002824888,
0.017410265,
-0.009429463,
0.03155446,
-0.033556245,
0.010548883,
0.013972989,
-0.008994865,
-0.0013433035,
-0.008389061,
0.02718214,
-0.008770981,
0.008237611,
-0.010456695,
-0.015632365,
-0.011806584,
-0.012649441,
0.030158479,
-0.0037401782,
-0.01028549,
0.009785044,
0.0021433593,
-0.000009986549,
0.013116963,
0.0049056914,
-0.011411495,
0.018450668,
-0.0050439727,
0.036137495,
0.011556361,
-0.0063971533,
0.028472764,
-0.021137275,
0.044671424,
0.0029187219,
-0.011819753,
0.018477008,
-0.0041188053,
0.0033187496,
0.011944865,
-0.010443525,
0.025562273,
0.020518301,
-0.006604575,
0.0058769523,
0.008929017,
0.0072169635,
-0.021242632,
0.019530578,
0.011029575,
-0.0018667966,
0.026010042,
0.011839508,
0.040536158,
0.021492856,
0.00956116,
-0.010963727,
0.0110361595,
-0.0049616625,
-0.018582365,
-0.022875667,
0.0036084817,
-0.010647655,
-0.01120078,
0.008224441,
0.007151115,
-0.018029239,
0.010173548,
-0.021255802,
0.013446204,
0.034688834,
-0.015276784,
-0.002429799,
0.008369307,
0.012550669,
-0.024877453,
-0.032766066,
0.037296426,
0.018477008,
-0.002582896,
-0.014591963,
-0.008448325,
0.029447319,
-0.014670981,
-0.008356137,
0.013986159,
0.017002007,
0.0047344863,
-0.002197684,
0.017555133,
0.019227676,
0.019412052,
-0.0049880017,
0.0032644249,
0.026563168,
-0.0021614674,
-0.02024174,
-0.017107364,
-0.02535156,
0.008691964,
-0.0022207308,
-0.027629908,
-0.016448881,
-0.040299103,
-0.014078347,
-0.024390176,
0.0059954794,
0.0032792408,
-0.03626919,
0.013393525,
-0.01320915,
0.0165279,
0.018608704,
0.020162722,
-0.025154015,
-0.015145088,
-0.020900222,
0.0009589145,
0.014157365,
0.07116874,
-0.0003775983,
-0.0057584257,
0.016132811,
0.028920533,
-0.03239732,
-0.031528123,
-0.020044195,
-0.003328627,
-0.008705133,
0.008310044,
-0.0039179684,
0.013722766,
0.01270212,
0.02427165,
0.02939464,
-0.015145088,
-0.03308214,
-0.013749106,
-0.019306695,
0.02136116,
-0.022322543,
0.0046422984,
0.025957363,
0.027498212,
-0.012708704,
0.044671424,
0.018121427,
-0.010140624,
-0.025167186,
0.017976562,
0.027893301,
-0.013149887,
0.006298381,
-0.022730801,
-0.0057748877,
0.034688834,
0.02165089,
0.04216919,
-0.01543482,
0.0063082585,
-0.013722766,
0.006650669,
-0.0020429406,
0.030369194,
-0.02427165,
-0.0138676325,
0.033924997,
0.0040167407,
-0.028578123,
0.03266071,
0.006594698,
0.015013391,
-0.021966962,
0.028525444,
-0.008869753,
-0.012603347,
-0.009594084,
-0.015224106,
0.0021631136,
0.0068877228,
-0.0070720976,
-0.026549997,
-0.0041583143,
-0.0032150387,
-0.017120535,
-0.024166292,
0.02317857,
0.005662946,
-0.008955357,
0.02498281,
-0.011253458,
-0.0010494558,
0.035452675,
0.0059823096,
0.010647655,
0.02503549,
-0.025074998,
0.01214241,
0.031844195,
-0.005310658,
0.009409709,
-0.010048437,
-0.026721202,
0.009692856,
-0.0029944472,
-0.016027454,
-0.014578793,
-0.0100879455,
0.021545533,
-0.0036809149,
0.0049386155,
-0.003040541,
-0.011286383,
-0.012800892,
0.043433476,
-0.015250445,
0.0017581471,
0.0037204237,
-0.016396204,
0.02897321,
-0.002791964,
-0.028709818,
-0.038402677,
0.005712332,
-0.007164285,
-0.012820646,
0.012274106,
-0.010147208,
-0.02681339,
0.032423656,
-0.028815176,
-0.0060349884,
0.0073223207,
-0.016040623,
0.007822767,
-0.017792186,
0.024192631,
0.02570714,
-0.020531472,
0.017054686,
-0.0014182058,
0.012570423,
-0.0049880017,
-0.030711604,
-0.002470954,
-0.012550669,
-0.010627901,
-0.0024182755,
-0.011306137,
0.009686272,
0.018793078,
-0.003345089,
-0.0194779,
-0.01619866,
-0.009903571,
0.014512945,
-0.0033582586,
0.0054193074,
-0.033213835,
-0.03374062,
0.0046422984,
0.0019408759,
-0.017779017,
0.036111157,
-0.025588613,
0.0038323656,
0.026431471,
0.022348883,
0.02096607,
-0.024113614,
0.0037829794,
-0.0050275107,
0.02313906,
-0.0061963163,
-0.003450446,
-0.01028549,
0.020386605,
0.025167186,
0.021176783,
0.009403124,
-0.013683258,
-0.007750334,
-0.010614731,
-0.00012819823,
-0.001651967,
0.01083203,
0.010035267,
-0.013735936,
0.030895978,
0.014104686,
0.008961941,
0.02313906,
0.0029911548,
0.03263437,
0.010483035,
-0.019174999,
-0.03682232,
-0.015474329,
-0.038824104,
-0.028367408,
-0.012833816,
-0.02205915,
-0.00068482134,
-0.022111828,
0.014012499,
0.0034537385,
0.0022124997,
-0.0011745674,
0.0057551335,
0.000537486,
0.0018355187,
-0.0075132805,
0.009890401,
-0.0055180797,
-0.027656248,
-0.006867968,
-0.03563705,
-0.014605133,
0.0033845978,
0.0013968052,
0.0006049804,
0.012761382,
-0.023297096,
0.00059963024,
0.017805355,
-0.015158257,
-0.000103865255,
0.0071906243,
-0.032212943,
-0.013301338,
-0.0058440287,
-0.0047377786,
-0.006881138,
-0.026642185,
0.008402231,
-0.013373771,
0.02315223,
-0.0016116349,
-0.019583257,
-0.011069084,
-0.019030131,
0.010713504,
-0.012313615,
0.020070534,
0.00059674936,
-0.025140846,
-0.0095282355,
-0.0061172983,
0.009844307,
-0.004806919,
0.018266292,
0.023929238,
-0.001540025,
-0.007750334,
-0.00007073538,
0.024100443,
-0.021716738,
-0.022678122,
0.015790401,
0.013670088,
0.0037039616,
-0.03339821,
-0.0013803431,
-0.013334262,
0.028051337,
0.010792521,
-0.007533035,
0.011694642,
-0.010496205,
-0.012438727,
0.03234464,
-0.026602676,
0.018990623,
0.0025483256,
-0.01875357,
-0.0071774544,
0.00053872063,
-0.0095743295,
0.0009128208,
-0.007710825,
0.017462945,
-0.0029730466,
0.009850892,
0.015843078,
0.0016248046,
-0.0065156803,
0.015658705,
-0.019991515,
0.03229196,
0.005014341,
0.0053797984,
0.0091529,
0.012629686,
0.016396204,
-0.01174732,
0.010785936,
-0.004428292,
-0.055681244,
-0.0023046872,
0.021756249,
0.027708925,
0.009686272,
0.0077305795,
-0.026010042,
0.007993973,
0.009133146,
-0.02493013,
0.0029582307,
-0.0023672432,
-0.03919285,
-0.021611381,
0.014578793,
0.012175334,
-0.00717087,
-0.0008766043,
0.002599358,
0.031343747,
-0.016975667,
0.031422764,
-0.0070128343,
0.0026207587,
-0.0025483256,
-0.0020725722,
0.0019277063,
-0.015922097,
0.024995979,
-0.026945086,
-0.046962943,
-0.011444419,
0.011049329,
0.015711382,
-0.014776338,
-0.008961941,
0.0010774413,
0.023929238,
-0.0050077564,
-0.019227676,
-0.020083703,
0.010377677,
-0.027498212,
0.0031195588,
0.03374062,
-0.026734373,
-0.0054884483,
-0.014104686,
0.043459818,
-0.00040434915,
-0.022388391,
-0.0008412108,
-0.03300312,
-0.004869475,
-0.018187275,
0.0031640064,
-0.0055213724,
-0.012833816,
-0.025246203,
0.036137495,
0.01835848,
0.0049517853,
0.0083297985,
-0.00956116,
0.006907477,
-0.005132868,
-0.03861339,
0.008007142,
-0.010568637,
-0.027050443,
-0.021901114,
0.018885266,
-0.027498212,
0.037586156,
0.018595533,
-0.013018191,
-0.022204015,
-0.016488392,
-0.04783214,
-0.000978669,
0.003690792,
0.025180355,
-0.0023771203,
0.0012470004,
0.0072301333,
0.025917854,
0.0030174942,
0.013176226,
0.012102901,
-0.031791516,
0.013386941,
-0.0025466795,
-0.0033780131,
-0.030553568,
-0.02274397,
-0.005350167,
0.020821203,
0.008922433,
-0.024943301,
0.029631693,
-0.005113113,
-0.009929909,
-0.005109821,
0.008711718,
-0.021874774,
-0.014289062,
0.028051337,
-0.0014494837,
-0.0083297985,
0.0038718747,
-0.0032216236,
-0.007454017,
-0.009383369,
0.028709818,
0.012096316,
0.0055378345,
0.007236718,
-0.029499996,
0.002823242,
-0.01692299,
0.0062621646,
-0.008000557,
-0.012096316,
0.025601784,
-0.009297767,
0.015447989,
-0.0027524552,
0.015026561,
-0.018832587,
-0.021018747,
0.02383705,
-0.0050670197,
-0.007565959,
0.014802678,
-0.007197209,
0.00076507387,
0.002062695,
-0.015540177,
0.0059329234,
0.0065321424,
0.011562945,
-0.004243917,
-0.011688057,
0.012754798,
-0.012767968,
-0.011694642,
-0.031633478,
-0.016211828,
-0.01619866,
-0.016409373,
0.018885266,
-0.0047509484,
-0.000012526592,
0.010720088,
0.014908034,
-0.008724888,
0.0034669081,
0.03561071,
0.18869463,
-0.022177676,
-0.013202566,
0.012148994,
-0.0224279,
0.00680212,
0.024943301,
-0.0042373324,
-0.012965512,
0.018898435,
-0.0032710098,
-0.01692299,
-0.035768747,
0.005593805,
0.017146874,
-0.015816739,
-0.012873325,
-0.025417408,
-0.026181247,
0.0077700885,
-0.023441961,
-0.010206472,
-0.001412444,
0.011641963,
0.026352452,
0.029183926,
-0.003746763,
0.007118191,
0.012504575,
-0.007052343,
-0.021927454,
-0.004115513,
-0.019635936,
0.0011210657,
0.0033664897,
-0.013070869,
0.012873325,
-0.008909263,
0.0047509484,
0.0066934703,
0.01304453,
0.014578793,
-0.009732365,
-0.013103793,
-0.0005222586,
0.045277227,
-0.0078030126,
-0.008553682,
0.0055312496,
0.0010519251,
-0.034662496,
-0.020781694,
0.031054014,
0.012530914,
-0.02907857,
0.02352098,
0.0069206464,
0.022309372,
-0.016343525,
0.025206694,
0.011292968,
0.0018190567,
-0.012669195,
0.01766049,
-0.0137754455,
0.01193828,
0.0024742463,
-0.0034833702,
0.0011827984,
-0.021400668,
-0.010706918,
-0.0014289061,
-0.0117670745,
0.013380356,
-0.0133079225,
-0.021150444,
0.025496425,
0.022572765,
0.0135252215,
0.033661604,
-0.01304453,
0.0012972096,
-0.011523437,
-0.0071906243,
-0.0033747207,
-0.027234819,
0.0016420897,
0.0055147875,
0.004622544,
-0.0063576447,
-0.0053139506,
-0.0029088445,
0.0063411826,
0.001090611,
0.027893301,
0.011707812,
-0.008421985,
0.0006691824,
0.0018174106,
-0.015671873,
-0.016040623,
0.081388384,
-0.009067298,
0.009949665,
-0.0016256276,
0.008836829,
-0.000038351438,
0.010213057,
0.0018190567,
0.0070391735,
0.013617409,
-0.032212943,
0.02424531,
-0.008204686,
-0.0063411826,
0.0047608255,
-0.017489284,
-0.03384598,
0.008000557,
-0.0064893407,
-0.0030866347,
-0.039772317,
-0.0043756133,
0.029131247,
-0.023718525,
0.0027475164,
-0.050466068,
-0.017831694,
-0.01065424,
-0.0049748323,
0.0075593744,
-0.03374062,
0.008863169,
-0.010983481,
-0.010074776,
0.0039805244,
0.009929909,
0.0049616625,
0.012530914,
-0.013538391,
0.008849999,
-0.016356695,
-0.027945979,
0.02205915,
-0.012952343,
-0.017831694,
0.019965177,
0.010878124,
0.00013241664,
-0.025417408,
-0.02678705,
0.006867968,
0.00019754462,
0.00024734234,
0.042116515,
-0.040193748,
0.002447907,
-0.014591963,
-0.00026442172,
0.024087274,
-0.02237522,
-0.01012087,
0.017449776,
0.011609039,
-0.00093833695,
0.0067626107,
-0.16488391,
0.010805691,
0.016830802,
-0.0129194185,
0.025628122,
-0.0031146202,
-0.009554575,
0.009422879,
-0.008138838,
-0.006193024,
-0.0012330076,
-0.025970533,
-0.027682586,
-0.028183034,
0.021440176,
0.009403124,
-0.021018747,
0.038297318,
0.026721202,
0.009785044,
0.0129194185,
-0.0064300774,
-0.0018684429,
-0.0041747764,
0.01506607,
0.013202566,
-0.02277031,
-0.01950424,
-0.022559596,
0.010720088,
-0.008975111,
0.015355802,
0.0264183,
-0.012958927,
0.011661718,
-0.0021943916,
-0.007454017,
-0.0031179127,
-0.0016330356,
0.008448325,
0.019491069,
0.044144638,
-0.005353459,
0.015566517,
-0.013972989,
-0.0046916846,
0.0077964277,
-0.032845087,
-0.0180029,
-0.0030142018,
-0.0032380857,
0.0013013252,
0.025970533,
-0.008132254,
-0.012583593,
-0.0033401502,
0.015316294,
-0.001090611,
0.0035195868,
0.007954463,
-0.0071116067,
-0.030105801,
0.012807476,
0.013762276,
0.011108593,
-0.032871425,
-0.0025878346,
-0.0007914131,
-0.00882366,
0.009640178,
-0.01542165,
-0.014157365,
0.0047246087,
0.0074803564,
0.021598212,
-0.0000054755615,
0.0004597028,
-0.010265736,
-0.0026602675,
0.0072103785,
0.0061666844,
0.021453345,
-0.029895086,
-0.02462723,
-0.0024940008,
0.011832923,
0.025456917,
0.012583593,
-0.010891293,
-0.020057363,
0.0138676325,
-0.038481694,
0.018674552,
-0.03150178,
0.026589505,
0.0330558,
0.009403124,
-0.031159371,
0.0026042967,
-0.039851334,
0.02245424,
-0.0073025664,
-0.007921539,
-0.0021054964,
0.017871203,
-0.0028841514,
-0.012636271,
-0.020031026,
0.048358925,
-0.0006123883,
-0.0062786266,
0.0054423544,
0.0127943065,
0.0020906806,
-0.0027936103,
0.026852898,
-0.005406138,
-0.0045204796,
-0.013512053,
-0.03123839,
0.053495083,
0.013735936,
-0.00012603759,
-0.018490177,
0.012412387,
-0.010502789,
-0.119474985,
0.013274998,
0.04158973,
0.01156953,
0.009304352,
0.017699998,
-0.019701784,
-0.011839508,
-0.036479905,
0.0055213724,
-0.007407923,
-0.03200223,
-0.015606025,
0.0009910156,
0.021255802,
-0.02350781,
0.019227676,
-0.056787495,
-0.019056471,
0.00917924,
-0.0020149553,
-0.0002761509,
-0.008402231,
0.006723102,
-0.0010897878,
-0.017699998,
-0.032871425,
0.005610267,
0.014052007,
0.03126473,
-0.019991515,
0.0024116905,
0.00457645,
-0.011615624,
-0.018951114,
-0.0074803564,
0.0027425778,
-0.022414729,
0.040009372,
-0.027261158,
-0.0007951171,
-0.00031133855,
0.0133079225,
0.0010033621,
0.0010815568,
-0.019925667,
0.002856166,
0.022138167,
0.014908034,
-0.020663168,
-0.04108928,
-0.022296203,
-0.012465065,
-0.007533035,
0.02425848,
-0.015724553,
0.019293524,
0.005047265,
0.0012066684,
0.00588683,
-0.013656918,
0.017792186,
-0.009673102,
0.0187404,
0.028051337,
-0.017752677,
0.0044678007,
-0.01506607,
0.0021960377,
-0.00009656022,
-0.019570088,
-0.0022487163,
-0.019069642,
-0.013360601,
-0.025628122,
-0.0093702,
-0.00016369452,
0.004619252,
0.015619195,
0.0010601562,
-0.017423436,
-0.0056925775,
0.028867854,
-0.013228905,
0.019293524,
0.0035031247,
0.0015737722,
-0.011951449,
0.0019375836,
-0.0059428005,
0.013920311,
0.0293683,
-0.0060942518,
-0.028499104,
0.022730801,
-0.014815846,
-0.0015095702,
-0.030790621,
0.027998658,
0.03189687,
-0.023744864,
0.0035953121,
-0.04856964,
0.0049320306,
0.00025228094,
-0.0013737582,
-0.0025219864,
-0.0030701726,
0.032845087,
0.000012610189,
-0.004349274,
0.0027442242,
-0.043591514,
0.0404308,
-0.0055707586,
0.0134791285,
-0.0064893407,
-0.0044875555,
0.016475221,
0.010397432,
0.004049665,
0.011852677,
-0.016106471,
0.020952899,
0.014012499,
0.0052678566,
0.00051443913,
0.004622544,
0.01064107,
0.015948435,
-0.022730801,
0.016975667,
-0.0020791572,
-0.0100879455,
-0.021492856,
0.01731808,
-0.0117209805,
-0.017436605,
0.0027359931,
0.015974775,
0.01360424,
0.04198482,
-0.017462945,
-0.010976897,
-0.0060679126,
-0.021347988,
-0.0048727673,
0.0044480464,
-0.015882587,
0.01729174,
0.0062424103,
-0.0023326727,
0.03268705,
0.010331584,
-0.0093702,
-0.012168749,
-0.000071352704,
-0.00034529154,
-0.016132811,
0.00044982557,
-0.031001337,
-0.0142100435,
-0.0009770228,
0.015764061,
-0.008764396,
0.017186383,
0.0099628335,
-0.024021426,
-0.004803627,
-0.027945979,
0.014131025,
-0.011154686,
-0.018674552,
-0.0018799664,
-0.0106015615,
0.01689665,
-0.0010864955,
0.0052974885,
-0.010726673,
0.011628794,
-0.009409709,
0.029816069,
0.043617852,
0.014499775,
-0.013735936,
0.011819753,
0.038297318,
0.022599105,
-0.016001115,
0.01723906,
0.009929909,
0.007342075,
0.0110361595,
0.013281584,
0.014157365,
0.0010041852,
0.0051789614,
0.02024174,
-0.012603347,
0.021585042,
-0.003657868,
0.028051337,
0.023481471,
0.011424664,
-0.0036677453,
-0.03787589,
-0.013670088,
-0.014565623,
-0.015698213,
-0.029210266,
-0.00697991,
0.013709597,
0.014815846,
-0.0044645085,
-0.015790401,
-0.0018635043,
-0.0072498876,
0.0032825333,
0.0069733253,
-0.029947765,
-0.028156694,
-0.005817689,
-0.0011688056,
0.016883481,
-0.003096512,
0.004523772,
0.026036382,
-0.0030125554,
-0.0061798543,
-0.0036545754,
0.023204908,
-0.013406695,
0.008059821,
-0.026247095,
-0.038429014,
0.0017976561,
-0.0024676616,
-0.031001337,
0.039429907,
-0.0008938894,
0.016066963,
0.05615535,
-0.009297767,
-0.007381584,
0.011339061,
-0.011437833,
-0.003088281,
0.014631472,
0.005633314,
-0.013215736,
-0.002431445,
0.009093638,
-0.02574665,
0.017950222,
-0.038797762,
-0.006657254,
0.015685042,
-0.008046651,
0.030974997,
-0.00029528805,
0.0015285015,
0.0062193633,
0.010805691,
-0.0121885035,
0.005646484,
-0.02612857,
-0.012550669,
0.0034669081,
-0.008909263,
0.006364229,
-0.0115827,
-0.0009654993,
0.005165792,
-0.029499996,
-0.0058275666,
0.03194955,
0.003746763,
-0.014987052,
-0.03418839,
0.0067823655,
0.017160043,
0.0026602675,
0.017041516,
-0.029341962,
-0.018990623,
-0.03013214,
-0.005432477,
0.018266292,
-0.020663168,
-0.033608925
] |
Background: The loss of a child during pregnancy causes significant psychological distress for many women and their partners, and may lead to long-lasting psychiatric disorders. Internet-based interventions using exposure techniques and cognitive restructuring have proved effective for posttraumatic stress disorder (PTSD) and prolonged grief. This study compared the effects of an Internet-based intervention for parents after prenatal loss with a waiting list condition (WLC). Methods: The Impact of Event Scale - Revised assessed symptoms of PTSD; the Inventory of Complicated Grief and the Brief Symptom Inventory assessed depression, anxiety, and general mental health. The 228 participants (92% female) were randomly allocated | [
-0.016251924,
0.0017838293,
0.022878531,
-0.027604172,
-0.021339016,
0.0012776301,
0.00202145,
-0.013574506,
-0.0022875185,
-0.015796762,
-0.030174494,
0.026626915,
-0.010107251,
0.028675139,
0.0012383055,
0.026707238,
0.044927064,
0.010067089,
-0.0033099572,
-0.019906597,
-0.010756524,
0.0087083,
0.0048026172,
-0.0002179585,
0.0114526525,
-0.004869553,
0.006358866,
-0.024551917,
-0.0014868033,
-0.016599987,
-0.016573213,
-0.008012172,
-0.013989505,
-0.024605466,
-0.020709824,
-0.012135394,
0.0052276575,
-0.016626762,
0.024003046,
-0.00446794,
0.022731273,
0.034940295,
-0.01061596,
0.008895719,
-0.00045934442,
0.0064860433,
-0.013748538,
-0.018849019,
-0.011974749,
0.011459346,
0.020214502,
-0.004939835,
0.006757132,
-0.0011839204,
-0.0054451977,
-0.0048026172,
-0.0046419725,
0.012088539,
0.026385948,
-0.020241275,
-0.0096387025,
-0.014190312,
-0.024779497,
0.016747246,
-0.007751123,
-0.007710962,
-0.009478058,
0.02085708,
-0.012550394,
0.013654828,
0.050924476,
0.030013848,
-0.009457977,
-0.0065195113,
0.0040094326,
0.008735074,
-0.009531606,
-0.017001601,
0.02008063,
0.02329353,
0.017724503,
0.0030957637,
-0.0016792427,
0.020442082,
0.006563019,
-0.008607897,
0.007155398,
0.004193505,
-0.0040931017,
-0.008882332,
-0.0026606836,
0.035181265,
-0.0045348755,
0.01879547,
0.01456515,
0.020749984,
-0.011251846,
0.04471287,
-0.011305395,
-0.032557394,
-0.022155628,
0.0053314073,
-0.0016507951,
-0.011660152,
0.0144045055,
-0.02251708,
-0.0025519135,
-0.011245153,
0.016091278,
-0.0044779805,
-0.04677448,
0.018996276,
0.0027811672,
-0.0023310264,
-0.011887733,
0.00083334616,
0.007021527,
0.0014332549,
-0.016064504,
-0.025154335,
0.022784822,
-0.012510233,
0.038153198,
0.011459346,
0.006817374,
0.012851603,
-0.019504985,
0.0012818136,
0.008226365,
0.009364267,
-0.01050217,
0.03394965,
0.019223856,
-0.011024266,
-0.04075029,
0.043347385,
0.0013797067,
-0.0324503,
-0.041419648,
-0.027604172,
0.012510233,
0.027095463,
-0.010448622,
-0.02835385,
-0.023922725,
0.035850618,
0.011626685,
0.02803256,
-0.0041433033,
-0.010609266,
-0.0070683816,
-0.027416753,
-0.020656275,
-0.0041265693,
0.002571994,
-0.008621284,
0.02325337,
0.017496923,
-0.022771435,
-0.032102235,
-0.013561118,
0.011432572,
-0.010763218,
0.02945159,
0.0136615215,
0.0070014466,
0.0070014466,
-0.004059634,
0.00093793275,
-0.025154335,
0.0068374546,
0.004869553,
-0.030442236,
0.0059137456,
-0.016948052,
0.014498215,
0.0012458358,
0.022650952,
-0.0045817303,
-0.035716746,
-0.038019326,
0.007751123,
-0.010622653,
0.021794178,
-0.024324337,
0.00048235347,
0.0074097523,
-0.022999015,
-0.0067504384,
-0.0017570552,
-0.015087247,
0.015877085,
0.007958623,
-0.024739336,
-0.65243304,
0.0021252001,
0.031861268,
0.006653382,
0.014498215,
0.034378037,
0.00021304293,
0.009270557,
-0.023775466,
0.043534804,
0.022624176,
0.019156922,
-0.0005141478,
-0.008453946,
0.014190312,
-0.014712408,
-0.020415308,
0.012383055,
0.014712408,
-0.008166123,
-0.010026928,
0.024792885,
0.007490075,
0.010287976,
0.004029513,
0.011566442,
0.0130858775,
-0.007229027,
-0.0018223171,
0.024029821,
0.012764587,
0.030388687,
-0.015609343,
0.027818367,
0.052370284,
-0.030817073,
-0.008125962,
0.028112883,
0.020763371,
0.029076751,
-0.024203852,
-0.024270788,
0.018259985,
0.002013083,
-0.00022695295,
0.01943805,
0.0067638257,
-0.006623261,
0.009290638,
0.012610636,
0.016854342,
0.0036212069,
-0.0043876176,
-0.0059739873,
0.017068535,
-0.0029635662,
0.027550625,
-0.008969348,
0.01307249,
0.0066901967,
-0.003560965,
-0.0016876096,
0.0089626545,
-0.019009663,
-0.024458207,
0.035127714,
-0.0064726565,
0.00999346,
-0.009109912,
-0.0017905228,
0.024926756,
0.04297255,
0.00015426526,
-0.01722918,
0.024993692,
0.020160953,
0.029290946,
0.013527651,
-0.0043173353,
0.005833423,
-0.0045081014,
-0.02693482,
-0.008059026,
0.008346848,
0.030147718,
-0.0053280606,
0.0024096756,
0.0025385262,
-0.00067311944,
-0.0070148334,
-0.0022875185,
0.010147411,
-0.028193204,
-0.013433942,
-0.012309426,
0.027550625,
-0.000016027898,
0.0077444296,
0.021258693,
-0.0003102039,
-0.008949268,
-0.008721687,
-0.00079360325,
0.005699552,
0.017952083,
0.006459269,
-0.020187726,
-0.003378566,
0.050174803,
0.00997338,
0.0011094548,
0.009565073,
0.007195559,
-0.015582569,
0.02472595,
-0.018126115,
-0.009732412,
-0.009913138,
-0.02821998,
-0.0074231396,
0.025181111,
-0.017202407,
0.013708376,
0.011686927,
0.0130524095,
0.018822243,
-0.0044947146,
-0.008413784,
0.020107403,
-0.00935088,
-0.010421847,
-0.0063856402,
0.019049825,
-0.0019227203,
0.0026707237,
0.0050803996,
0.01539515,
-0.010823459,
0.00925717,
-0.032316428,
-0.015729826,
0.012101926,
0.007938542,
-0.009397735,
-0.018326921,
-0.03914384,
0.01732289,
0.0071620913,
-0.0018474179,
0.011753862,
0.012777974,
-0.037831906,
0.0016190008,
0.010696283,
-0.009665476,
-0.006539592,
-0.003781852,
-0.033601586,
-0.013828861,
-0.0129587,
0.01773789,
0.008474026,
-0.005277859,
-0.0036680617,
-0.01498015,
-0.03183449,
-0.0073495107,
0.014819505,
-0.007851526,
-0.0019043131,
0.0019277405,
-0.033521265,
-0.016278697,
0.023454176,
-0.0021971555,
0.010629347,
0.020067243,
-0.012209023,
-0.0197995,
0.022691112,
0.009417815,
-0.008835477,
-0.012142087,
0.0012257551,
0.001624021,
0.026037883,
-0.0008325094,
0.035341907,
-0.0067403982,
0.0060308827,
0.0061346325,
0.021298856,
-0.016466117,
0.024391271,
-0.014377731,
0.012831522,
-0.017028375,
0.005130601,
-0.0087083,
0.046051577,
0.022972241,
-0.010194266,
0.01764418,
0.015783375,
0.01677402,
-0.018581277,
-0.007550317,
-0.030147718,
0.0039023357,
-0.0027661067,
-0.010970717,
0.015984181,
-0.0123428935,
-0.020348372,
-0.015649505,
0.030843848,
0.0012659164,
0.006040923,
-0.012028297,
0.0049465285,
0.0027912075,
-0.023173047,
0.030495783,
0.0046419725,
-0.027363205,
0.012088539,
-0.0013981139,
0.008942574,
0.012135394,
-0.020428695,
-0.0022523773,
0.040402226,
0.0034839893,
0.02214224,
-0.014150151,
-0.000871834,
0.020107403,
-0.017255954,
0.058046408,
0.01392257,
-0.00078105286,
0.024471594,
0.02123192,
-0.007061688,
0.01571644,
0.0075837844,
0.031727396,
-0.0046419725,
-0.018072568,
-0.0010634367,
-0.016559826,
0.02682772,
-0.041794486,
0.004909714,
-0.009270557,
0.0018373777,
0.010100557,
0.0012374688,
0.028889334,
0.016934665,
0.011017572,
-0.01751031,
0.020482242,
0.0038822552,
0.006606527,
-0.006927817,
-0.0040127793,
0.0057263263,
-0.010763218,
-0.014203699,
-0.005994068,
-0.016948052,
0.0076641073,
-0.006743745,
0.016827568,
0.012717732,
0.018393857,
-0.005625923,
0.018942727,
-0.014484827,
-0.026506431,
-0.02223595,
0.026078045,
0.041473195,
-0.011753862,
-0.005174109,
0.0032380016,
0.002081692,
0.00026983346,
-0.0018925994,
0.010187573,
0.01242991,
0.023454176,
0.0014240514,
0.0012190616,
-0.022677725,
0.008601204,
-0.0038956422,
0.0047624563,
0.00047482323,
0.012048378,
0.012483458,
-0.04227642,
-0.00015217352,
-0.0030890703,
0.0069144303,
-0.033387393,
-0.029612236,
-0.003530844,
0.00531802,
0.017001601,
-0.017590633,
0.0071687847,
-0.0011437592,
-0.0030204614,
-0.0026556633,
0.0018959461,
-0.0030589493,
-0.015140795,
0.0033116306,
-0.0009488098,
-0.0030773566,
-0.02113821,
-0.014176925,
0.067470916,
0.026412722,
-0.002598768,
0.013962732,
0.0048093107,
-0.011532975,
-0.015288053,
-0.031914815,
0.0077176555,
-0.0022523773,
0.002754393,
0.0028631631,
-0.0005681145,
-0.0056192297,
0.010341524,
0.020763371,
0.016198374,
-0.034110297,
-0.009578461,
-0.017590633,
0.009411122,
0.0011805737,
0.010140718,
0.03464578,
-0.000722066,
-0.015984181,
0.03376223,
0.03785868,
-0.0127712805,
-0.005482012,
-0.008520881,
0.020629501,
-0.0037751584,
0.03239675,
-0.022584016,
0.022664338,
0.008701607,
0.008467332,
0.0324503,
0.012818135,
0.014939989,
-0.003517457,
0.010462008,
-0.006643342,
0.004163384,
-0.014873053,
0.022222564,
0.027229335,
-0.003560965,
-0.012630716,
0.02306595,
0.009457977,
-0.017403213,
-0.027818367,
0.020107403,
-0.016479503,
0.004792577,
-0.008648058,
-0.005508786,
0.001713547,
0.00020352555,
-0.029398043,
-0.017389826,
-0.017537083,
-0.020495629,
-0.018447405,
0.003248042,
0.0066935434,
-0.03759094,
-0.025355142,
0.004367537,
-0.0025569336,
-0.015529021,
-0.005418423,
0.004739029,
-0.008527574,
0.026078045,
-0.008701607,
0.0056326166,
0.028086107,
-0.025261432,
-0.0053113266,
-0.002732639,
0.0033015902,
0.030763526,
0.017041761,
0.0030740097,
-0.012269265,
-0.018862406,
0.0035977794,
-0.008052332,
-0.021887887,
-0.0144045055,
-0.0010048682,
0.007048301,
0.023976272,
-0.009946605,
0.017014988,
0.012289345,
-0.025060626,
0.018621437,
-0.03445836,
-0.018915953,
-0.023427403,
-0.008313381,
0.00029054162,
-0.008922493,
-0.0017637487,
0.0073695914,
-0.026426109,
0.022584016,
-0.016064504,
0.018956115,
0.012403136,
0.009792654,
0.044043515,
0.012255878,
0.028782235,
0.029853202,
-0.016198374,
-0.005271165,
-0.040188033,
0.014873053,
0.0042972546,
-0.0024782845,
0.006194874,
0.0011529628,
-0.031861268,
-0.012818135,
-0.009411122,
-0.011867653,
0.02315966,
0.014886441,
-0.004116529,
-0.021124823,
-0.011921201,
-0.007095156,
0.030656429,
0.0028112882,
-0.021339016,
-0.006552979,
-0.024685787,
-0.00553556,
-0.01805918,
0.050763834,
-0.031539977,
-0.0218745,
0.014632085,
-0.01220233,
0.03028159,
-0.030763526,
-0.006184834,
-0.036868036,
0.013032329,
-0.015221118,
-0.052182864,
-0.0050168107,
0.003266449,
0.024779497,
0.012389748,
0.024605466,
0.0011061081,
0.017135471,
-0.0028815705,
0.019237243,
-0.021191759,
0.016412567,
-0.0022992322,
-0.0061814873,
0.024297561,
0.021954821,
-0.0008366929,
0.033199973,
-0.007992091,
0.02697498,
0.020776758,
-0.016653536,
-0.035422232,
0.0044980613,
-0.021245306,
0.0028715301,
-0.013045716,
-0.011030959,
0.01125854,
-0.037805133,
0.006807334,
0.026519818,
-0.014846279,
0.0073628975,
0.0023126192,
0.022356436,
-0.0210445,
-0.0013345252,
-0.0029351187,
0.0056794714,
-0.0016993233,
-0.012182249,
-0.007108543,
-0.009866283,
0.002250704,
0.008152735,
0.029049978,
-0.0077444296,
0.007637333,
-0.019330952,
0.010642734,
-0.018541114,
0.0107766045,
-0.016385794,
-0.005438504,
-0.0031509856,
0.004233666,
-0.0064023742,
-0.014350957,
-0.0071018497,
0.004749069,
-0.011104588,
0.03689481,
-0.015140795,
-0.022838369,
-0.037617713,
0.0049297945,
0.020509018,
-0.009819428,
0.02945159,
0.011506201,
-0.0064425357,
-0.02572998,
-0.0050904397,
-0.0045984644,
0.012496846,
0.009632009,
0.031004492,
-0.01176725,
0.001359626,
0.020187726,
0.024511756,
-0.029585462,
-0.019237243,
-0.007811365,
0.015087247,
-0.0045214887,
-0.0074633006,
-0.015194343,
-0.028594818,
0.01639918,
-0.018313535,
0.005087093,
0.018126115,
-0.014029667,
0.009230397,
0.01631886,
-0.032423522,
0.021017727,
-0.008012172,
0.0291303,
0.00955838,
-0.012550394,
-0.005994068,
0.004575037,
0.015140795,
0.011379024,
-0.016881116,
0.0013462389,
0.0023142926,
-0.0023644941,
0.0054418505,
0.001179737,
-0.0291303,
0.03617191,
0.02081692,
-0.002675744,
-0.00061957113,
-0.00700814,
0.010515557,
0.0017202407,
-0.003490683,
-0.041285776,
-0.014083215,
-0.008634671,
0.016104665,
-0.014806118,
-0.007891688,
-0.0053146733,
-0.013567813,
-0.005719633,
-0.007476688,
-0.03579707,
0.012851603,
-0.029398043,
-0.0186616,
-0.0058267293,
-0.016064504,
0.0065730596,
-0.0034772959,
-0.01856789,
0.0037985859,
0.021593371,
-0.028086107,
0.01870176,
0.01870176,
-0.0033735458,
-0.016211761,
0.028380623,
-0.012992168,
-0.025529174,
0.010227734,
-0.010167493,
-0.032959007,
0.0025084054,
-0.006097818,
0.0014868033,
0.00007702804,
-0.020803533,
0.02472595,
0.022503693,
-0.019558534,
-0.009772574,
-0.018728534,
0.008621284,
-0.0073227366,
-0.014150151,
0.022490306,
-0.016827568,
0.00978596,
-0.04112513,
0.027523851,
0.009109912,
-0.037457068,
-0.0054585845,
-0.001531148,
0.009076444,
-0.019906597,
-0.006111205,
-0.015810149,
-0.016800793,
-0.031272236,
-0.00052878994,
0.00827322,
-0.0016625088,
-0.0029719332,
-0.0031158444,
-0.00095634,
-0.0014273981,
0.0010943944,
-0.0046085045,
-0.029719332,
-0.009491445,
-0.034297716,
-0.0031074774,
-0.00806572,
0.036868036,
0.022128854,
-0.009799347,
-0.03796578,
0.00092789246,
-0.054244474,
0.02950514,
0.006097818,
0.00046227284,
0.010488782,
0.019357728,
0.0068943496,
0.0075703976,
0.008848865,
0.0214595,
-0.023721918,
-0.016024344,
0.004805964,
-0.0023126192,
0.032423522,
-0.007490075,
-0.021111436,
-0.013547732,
0.022302886,
-0.0114526525,
-0.0027460263,
0.0018842324,
-0.00038843468,
-0.012777974,
-0.005344794,
0.002904998,
0.0038487874,
-0.020964177,
-0.010348218,
-0.021526435,
0.009524913,
0.0070750755,
-0.001051723,
-0.0096387025,
-0.010763218,
0.04658706,
-0.014230473,
-0.016626762,
-0.046212222,
0.0161716,
0.013614668,
-0.024511756,
0.03253062,
-0.0010475395,
-0.010756524,
0.017014988,
0.013259909,
0.0017319543,
-0.010629347,
0.0020582646,
-0.01114475,
0.00053506513,
0.016533053,
-0.0074097523,
-0.01341386,
0.013025635,
0.008755155,
-0.018902566,
-0.0012500192,
-0.029799655,
0.00234274,
-0.021834338,
0.013641441,
0.025622884,
-0.009812734,
-0.015354988,
-0.0062651564,
-0.009819428,
-0.012603942,
-0.022932079,
0.0060476162,
-0.04650674,
-0.010950637,
-0.0025050587,
-0.00595056,
0.024297561,
0.0153282145,
0.005569028,
0.013989505,
0.027738044,
0.18902567,
0.0028681834,
0.0023276797,
0.020964177,
-0.0023310264,
-0.0073428173,
0.037644487,
0.009826122,
-0.024324337,
-0.00008461057,
0.000100769204,
0.011399104,
-0.005542254,
0.008982735,
0.0024080023,
-0.011720395,
-0.016867729,
-0.0031476389,
-0.0068943496,
0.011974749,
0.019679017,
-0.005023504,
0.020736597,
-0.010026928,
0.028086107,
-0.00034806426,
-0.02315966,
0.0044645933,
0.029237397,
0.0012818136,
-0.011138056,
-0.007918462,
0.003852134,
0.012229104,
0.0010701303,
-0.022851758,
0.010020235,
-0.019705791,
-0.0034204007,
-0.016881116,
-0.0069545917,
0.0049933833,
-0.001040846,
0.0075837844,
-0.026680464,
0.016372407,
0.007603865,
-0.02261079,
0.011539669,
-0.011780636,
-0.02210208,
0.0137619255,
0.005716286,
0.008895719,
-0.031700622,
0.009129993,
-0.0005154028,
0.0036948358,
-0.012349588,
0.0071420106,
-0.015676279,
-0.0061915275,
-0.02338724,
0.028300302,
-0.01348749,
0.0053012865,
-0.0039960453,
0.004290561,
-0.027738044,
-0.014136763,
-0.00276276,
-0.004611851,
-0.025234658,
0.017537083,
-0.04034868,
-0.020937404,
0.020763371,
0.018688373,
0.026198529,
0.02701514,
-0.00043717204,
-0.020522404,
0.0018407244,
0.0072424137,
-0.013842247,
-0.012275958,
0.020870468,
0.008875638,
-0.02325337,
0.0020314904,
0.011385717,
0.011566442,
-0.01745676,
-0.0059438664,
0.026252076,
-0.017296117,
0.017336277,
0.0062919306,
-0.01760402,
0.010261202,
-0.0065998337,
0.09103219,
-0.0033501184,
0.0018842324,
-0.01562273,
-0.009538299,
0.0014483155,
0.028434172,
-0.004548263,
0.01864821,
-0.010308057,
-0.020924017,
0.013607973,
-0.0006743745,
-0.016144827,
0.016921278,
0.006137979,
-0.018206438,
-0.003691489,
-0.006653382,
-0.0016282044,
-0.016666923,
0.0048360853,
0.017844986,
-0.004471287,
-0.008105881,
-0.011379024,
-0.0004953222,
-0.011479427,
-0.023039177,
0.002397962,
-0.025582723,
0.0020047163,
-0.013407167,
-0.009451283,
0.011646765,
0.029879978,
0.004906367,
0.0033450983,
0.027550625,
0.015100634,
-0.020656275,
-0.008427171,
0.001255876,
0.010381686,
-0.012952006,
0.0047524157,
0.027242722,
-0.042999323,
-0.014324183,
-0.048354156,
-0.015448698,
0.008226365,
-0.018393857,
0.011626685,
-0.027229335,
-0.021526435,
-0.016881116,
-0.0017938697,
0.012436603,
-0.01755047,
0.00013659011,
0.014886441,
0.008507494,
-0.017403213,
-0.01626531,
-0.17049794,
0.018915953,
0.021593371,
-0.020870468,
0.021660306,
0.0064090677,
0.025448851,
-0.0049364883,
-0.015609343,
0.014939989,
0.017898535,
-0.0076306392,
-0.017068535,
-0.0015252912,
-0.0059438664,
0.0010416827,
-0.001509394,
0.031861268,
0.019625468,
-0.0017972164,
0.01498015,
-0.020000307,
0.008467332,
0.00785822,
0.0027125585,
0.017858373,
-0.010221041,
0.00030497456,
0.006301971,
-0.031593524,
-0.028969655,
-0.004293908,
0.028889334,
0.013895796,
-0.02017434,
-0.0060007614,
0.006653382,
-0.03464578,
0.005866891,
0.024551917,
0.009042977,
0.0071754786,
-0.004247053,
0.010702976,
0.008012172,
0.008460639,
-0.0037751584,
-0.020535791,
-0.0016407548,
-0.002915038,
-0.017269341,
-0.028835785,
0.004575037,
-0.012858297,
0.00989975,
-0.003430441,
0.017563857,
-0.0144045055,
-0.000988971,
-0.00935088,
-0.009832815,
-0.016707085,
0.007530236,
0.011379024,
0.0049431818,
-0.047872223,
-0.011727088,
-0.009511525,
-0.027657721,
0.0017202407,
-0.030040622,
-0.024779497,
0.0054318104,
-0.0060074553,
0.0044512064,
0.030763526,
-0.024096755,
0.03520804,
0.0028347156,
0.021994984,
-0.0033718725,
0.015796762,
-0.027323043,
0.006332092,
-0.012891765,
0.023454176,
-0.0037048762,
0.0065563256,
-0.008119268,
0.004437819,
0.02274466,
-0.042517386,
0.0006727011,
-0.011111282,
0.0046988674,
0.006154713,
-0.006214955,
0.019357728,
0.010984105,
-0.003422074,
0.011707007,
0.002904998,
-0.012349588,
-0.0033584854,
0.028942881,
-0.010682895,
-0.021191759,
0.0017152205,
0.020964177,
-0.0056192297,
-0.024886593,
0.0047524157,
0.009304025,
0.011044347,
0.0073361234,
0.030120945,
0.031165138,
-0.00234274,
-0.0028715301,
-0.0068675755,
0.06971995,
-0.011733782,
-0.021646919,
0.001972922,
-0.0022573974,
-0.0146856345,
-0.11534314,
-0.031138364,
0.009578461,
0.023735305,
0.011158137,
0.020067243,
0.0022239299,
0.007905074,
-0.0032011871,
0.014083215,
-0.022865145,
-0.010535637,
-0.030656429,
0.0051406412,
0.024565304,
-0.025114175,
-0.011191605,
-0.014203699,
-0.0057263263,
0.040964484,
-0.00070909725,
-0.010348218,
0.021981597,
-0.02412353,
-0.004484674,
-0.02421724,
-0.0178316,
0.011312088,
-0.005893665,
0.0125905555,
0.009933218,
0.0054284637,
0.024498368,
-0.009779267,
-0.02251708,
-0.0029635662,
-0.04439158,
-0.0049364883,
0.034404814,
-0.0068474947,
-0.0030522558,
-0.0066299546,
0.019384502,
0.0043441094,
-0.0035341908,
-0.009732412,
-0.039599,
0.010535637,
0.027925463,
-0.034378037,
-0.01242991,
-0.019036436,
-0.009913138,
0.011004185,
0.014538376,
-0.024136918,
0.030549332,
0.014136763,
-0.02572998,
0.003942497,
0.024043208,
0.0062082615,
-0.026533205,
0.020160953,
0.0075904783,
0.006927817,
-0.014578537,
-0.022048531,
-0.008654752,
-0.010609266,
-0.02026805,
-0.014926601,
-0.0040964484,
0.0015989202,
-0.029049978,
0.0032681224,
-0.004759109,
-0.015381763,
0.0118475715,
-0.013674909,
-0.02109805,
-0.0076908814,
0.0035576182,
-0.019464824,
-0.005893665,
-0.0065429388,
0.0036412876,
-0.004722295,
-0.033012554,
-0.008561042,
0.001296874,
0.027256109,
-0.0001008215,
-0.018259985,
0.001444132,
0.0049297945,
-0.021981597,
-0.001656652,
0.035234813,
0.012931926,
-0.02435111,
0.0094245095,
-0.049210932,
0.024592077,
0.012175555,
-0.015381763,
-0.016439343,
0.0065027773,
0.01864821,
-0.0134473285,
0.0035944327,
0.015381763,
-0.016881116,
0.031780943,
-0.0036580213,
-0.0026824374,
-0.029879978,
-0.010060396,
0.0105958795,
0.008447251,
0.010468702,
0.020388532,
-0.0037149165,
-0.0013136079,
-0.018005632,
0.025944173,
-0.004544916,
-0.0032915499,
-0.023641596,
0.013962732,
-0.009551686,
-0.011151443,
0.012456684,
-0.024418047,
-0.025328368,
0.014591925,
-0.009484751,
-0.021285469,
0.008862251,
0.022463532,
0.039625775,
0.04401674,
-0.0127512,
0.009357573,
0.008527574,
-0.031272236,
0.009665476,
0.015595956,
-0.012436603,
0.012731119,
0.0037283036,
-0.001972922,
0.0323432,
0.0015336581,
0.0057865684,
-0.012764587,
-0.010923862,
0.002476611,
-0.003852134,
0.009652089,
-0.021861112,
0.011840878,
0.02261079,
-0.0033735458,
0.010850234,
0.027925463,
0.026948206,
-0.0068106805,
-0.016934665,
-0.021499662,
-0.0059606005,
-0.008092494,
-0.0057865684,
-0.009578461,
0.012456684,
0.014859666,
-0.00029054162,
0.009986767,
-0.0030773566,
-0.0072424137,
-0.00033467717,
0.017751276,
0.019933373,
0.024779497,
-0.043775775,
-0.013259909,
0.030120945,
0.00806572,
-0.013119345,
0.010100557,
0.0093308,
0.008601204,
0.0053481413,
-0.0036747553,
-0.0017252608,
0.0024347764,
0.010656121,
0.033012554,
-0.0019930026,
-0.0059539066,
0.020281436,
-0.0030171147,
0.017952083,
-0.00861459,
-0.0056928587,
-0.02380224,
-0.022932079,
0.0038922955,
-0.023213208,
-0.027135625,
0.0041299164,
0.005763141,
-0.013012248,
0.016385794,
-0.011191605,
0.015836924,
-0.016921278,
0.02191466,
0.008279913,
0.0070282207,
-0.0255024,
0.01107112,
-0.00467544,
0.013520958,
0.00030518376,
-0.01424386,
0.023146274,
-0.016640149,
0.019866437,
-0.03194159,
0.03424417,
0.004367537,
0.020468855,
0.0028983043,
-0.040214807,
-0.009893057,
0.028273527,
-0.04297255,
0.01769773,
0.01456515,
0.019397888,
0.06190189,
-0.0005994905,
-0.0042604404,
-0.009217009,
-0.0048427787,
-0.0007952766,
0.007449914,
0.027952237,
0.019183695,
-0.029933525,
0.0080724135,
-0.009076444,
0.03539546,
-0.027215946,
-0.011559749,
-0.010676201,
-0.005160722,
0.010267896,
0.005026851,
0.009116606,
0.027282882,
-0.015984181,
0.04016126,
0.023467563,
-0.018019019,
-0.0038789085,
-0.009223702,
-0.0037283036,
-0.01769773,
-0.012309426,
0.00010118755,
0.010950637,
-0.03611836,
-0.029049978,
0.008360236,
-0.015502246,
-0.013032329,
-0.022088693,
-0.0054016896,
0.017938696,
-0.0008743441,
-0.0050335447,
-0.020053856,
-0.011874346,
-0.013514264,
-0.028648365,
-0.0029217317,
-0.019143535,
-0.03491352
] |
INTRODUCTION Triglyceride accumulation in the liver is an early feature in the development of nonalcoholic fatty liver disease (NAFLD) associated with human obesity, which is a multifactorial syndrome and whose underlying mechanisms are beginning to be understood. OBJECTIVES Liver peroxisome proliferator-activated receptor-γ (PPAR-γ) mRNA expression was measured as a signaling mechanism related to steatosis in obese patients with NAFLD. METHODS Liver PPAR-γ and sterol receptor element-binding protein 1c (SREBP-1c) mRNA (real-time RT-PCR), serum total adipon | [
-0.017639533,
-0.022729611,
0.0029225647,
-0.031686068,
-0.02047748,
0.0053894958,
-0.03566961,
0.026582971,
-0.036893312,
-0.0040421216,
0.015426455,
0.013942391,
-0.005731221,
0.008787221,
-0.0047418447,
0.00048289035,
0.029525062,
-0.017340116,
0.010876627,
0.008709112,
-0.020308245,
-0.0033277532,
-0.012191456,
-0.016637139,
0.00384685,
0.0132003585,
0.02383615,
-0.047047433,
-0.01031034,
-0.028822085,
0.0007855613,
-0.008761185,
-0.008468278,
0.009021547,
0.020933114,
-0.013590902,
-0.014306898,
0.0035018704,
0.0046344455,
-0.016884483,
0.012640581,
-0.006277981,
0.008110279,
0.0022667777,
-0.0047939173,
0.0071013765,
0.0051226243,
-0.014788568,
-0.020230135,
0.037882686,
0.002517376,
0.017665569,
-0.013076687,
-0.025216071,
-0.0036125241,
0.0073747565,
-0.02349768,
0.018511746,
-0.006203127,
-0.028275324,
-0.010980772,
0.0012529927,
-0.031165345,
0.0011122344,
0.008422714,
0.029238665,
0.0035897426,
0.039496932,
-0.020386353,
0.0005540831,
0.0307748,
0.028691905,
0.0013229649,
0.0038175595,
0.0038370865,
-0.012132874,
-0.011058881,
-0.0064895255,
-0.0062617087,
0.004308993,
0.03223283,
-0.0013026241,
0.02274263,
0.029993715,
0.008585441,
-0.009119183,
-0.0027419385,
0.044339668,
0.004891553,
-0.0044587012,
0.011241134,
0.02192249,
0.026921442,
0.015777944,
-0.014059554,
-0.012041748,
0.006821487,
0.0075114467,
-0.0050575337,
-0.026947478,
-0.0038012867,
0.0107659735,
-0.0069126138,
-0.0027403112,
-0.025710758,
0.012900942,
-0.02507287,
0.016936556,
0.0011846476,
-0.006841014,
-0.002855847,
0.046474636,
0.0002499883,
-0.014606314,
0.011169534,
0.0037394508,
0.012237019,
0.01814724,
-0.017808769,
-0.03160796,
0.0107399365,
0.023758043,
0.013115741,
0.00511937,
0.0050738067,
-0.0036678512,
-0.016676193,
0.0119636385,
-0.018589854,
-0.004699536,
0.021870418,
0.0039412314,
0.011631677,
-0.010674846,
-0.018772108,
-0.0009169628,
-0.045875803,
0.0044456827,
-0.024500074,
-0.027624419,
-0.0069321413,
0.018693998,
-0.014983839,
0.003599506,
0.0039965585,
0.015751908,
0.0428556,
0.017509352,
-0.0026882389,
-0.009646416,
0.0020129245,
0.0120092025,
0.0295511,
-0.0061054914,
0.008344606,
0.0138382455,
0.0074658836,
0.023549752,
-0.0151010025,
-0.016454885,
0.01250389,
-0.0069907224,
0.0075179557,
0.011755349,
-0.0075765373,
0.024369894,
0.007680682,
-0.00008771966,
-0.002875374,
-0.015140057,
0.0011879021,
0.016845427,
-0.027103696,
0.029967679,
-0.00024063155,
0.009327472,
-0.0049436255,
0.0060241283,
-0.0022846775,
-0.023927277,
-0.012282582,
0.0030153187,
0.03382104,
0.0014523324,
-0.013929373,
-0.0006590416,
0.020841986,
-0.002855847,
0.0073552295,
-0.023068083,
0.015465509,
0.016884483,
-0.004872026,
-0.034341764,
-0.64153224,
-0.023185246,
0.010329867,
0.007680682,
-0.00089336745,
0.023653897,
0.016598085,
0.012718689,
-0.02913452,
0.027259912,
-0.023120156,
0.00628449,
0.0066555063,
-0.0012944879,
-0.010362412,
-0.013486757,
-0.028535686,
-0.009379545,
0.014580278,
-0.000106280626,
-0.01765255,
-0.0055294405,
0.014137662,
0.010596738,
0.01408559,
0.035226993,
0.0038663773,
-0.01620754,
-0.00059151015,
0.03119138,
-0.0006008669,
0.03241508,
0.010414484,
0.0040030675,
0.05566542,
-0.012536435,
-0.0046962816,
0.018199312,
0.041970372,
0.04355858,
-0.01064881,
-0.014957803,
0.020178063,
-0.002906292,
-0.033352386,
0.014111626,
0.022221906,
0.0066294703,
-0.0055880216,
-0.0058776746,
-0.01057721,
0.0054936404,
-0.015205147,
0.0021756508,
0.020633698,
-0.03202454,
0.0126145445,
-0.027806673,
0.00009763579,
0.015439473,
0.005435059,
0.017157862,
-0.0007522024,
-0.02446102,
-0.02219587,
0.013031123,
-0.020516533,
0.0088913655,
0.0021854145,
0.0044847373,
0.012907451,
0.037414033,
0.009581326,
0.007928026,
0.007784827,
0.009750561,
0.022690557,
0.033612747,
-0.006089219,
0.0053081326,
0.010076013,
0.010551174,
-0.03064462,
0.0033489077,
0.0144500965,
-0.008956457,
0.0029941641,
0.0082990425,
0.025385305,
-0.005298369,
0.008845802,
-0.0012554335,
-0.030904982,
-0.022547359,
-0.013096214,
0.027988926,
-0.026556935,
0.0021479875,
0.011215098,
-0.004094194,
-0.0153874,
-0.0138252275,
-0.0023172228,
-0.0028981557,
0.042334877,
0.0016842174,
-0.043376327,
-0.00707534,
0.0416319,
-0.027364057,
0.023406554,
-0.016402813,
-0.0061673275,
-0.014202753,
-0.011423388,
-0.01614245,
0.0073487204,
0.00056791486,
-0.011774876,
-0.033378422,
0.035982043,
0.00063015765,
0.014332934,
0.0018192802,
-0.00035433655,
0.019462068,
-0.0066294703,
-0.0015499681,
-0.003195945,
0.0024653038,
0.014853658,
0.0016988628,
0.021610055,
-0.005298369,
0.02259943,
0.0066555063,
0.012679635,
0.018693998,
0.010349394,
-0.056082,
-0.007993117,
0.004348047,
0.006788942,
-0.008292533,
0.0009242855,
-0.01209382,
0.018381564,
0.007869445,
0.011716295,
0.029733352,
-0.0025320214,
0.0036613422,
-0.014827622,
0.009744052,
0.0027338022,
0.006795451,
-0.0028770012,
-0.026465809,
0.00022171461,
0.009665943,
-0.007055813,
0.007661155,
-0.01895436,
0.008188388,
-0.023393536,
-0.009932814,
0.014957803,
-0.00033135148,
-0.012119856,
-0.009145219,
0.0045791185,
-0.014489152,
-0.013564866,
0.016741283,
-0.0008705858,
0.02666108,
-0.008468278,
-0.031868324,
0.010023941,
-0.00066555064,
0.008826275,
0.018537782,
-0.015270238,
0.024408948,
0.022482269,
0.005337423,
0.011442915,
0.026387699,
0.010980772,
0.020490497,
-0.019279813,
0.019136615,
0.0020129245,
0.02026919,
0.0036515784,
-0.014853658,
0.001985261,
-0.019800538,
-0.0053829867,
0.025111925,
0.023458626,
-0.022768667,
0.024513092,
-0.04046027,
0.01291396,
-0.016337723,
0.00015479341,
-0.0049696616,
-0.002930701,
-0.008819766,
-0.0024474037,
0.014554242,
-0.004569355,
-0.01779575,
-0.015114021,
0.009457653,
0.014892712,
-0.025111925,
0.025619632,
-0.041892264,
-0.0132003585,
-0.026088282,
0.010974263,
-0.001128507,
-0.023601824,
0.01655903,
-0.0029111737,
0.016168486,
-0.0051974785,
-0.010362412,
-0.009223328,
-0.020633698,
-0.007172976,
0.012764253,
-0.006554616,
-0.0037882687,
-0.005275587,
-0.021544965,
0.01691052,
0.0092754,
-0.00030267096,
0.013486757,
0.032076612,
-0.014970821,
-0.014371988,
-0.012393236,
0.01586907,
0.016624121,
-0.02707766,
0.007895481,
0.0044782283,
0.024018405,
-0.027936853,
0.016871465,
0.015569654,
-0.014332934,
0.014580278,
-0.009028056,
0.032545265,
0.020152027,
0.02274263,
0.012243528,
-0.0008600086,
-0.022156816,
0.025020799,
0.014411042,
0.010583719,
-0.020165045,
-0.0020259426,
0.008097261,
-0.025216071,
0.0038761408,
0.0049761706,
-0.027259912,
0.009301436,
-0.004507519,
0.02026919,
-0.00450101,
0.032805625,
-0.011449424,
0.001252179,
-0.02383615,
0.0307748,
0.024148585,
-0.016923537,
-0.025255125,
-0.043115966,
-0.0119961845,
-0.0022521322,
-0.00391845,
0.008663549,
0.009939323,
0.014411042,
0.0036873783,
-0.015686817,
-0.01484064,
0.035096813,
-0.023133174,
0.027598383,
-0.03704953,
0.012425781,
-0.004852499,
0.008956457,
0.002776111,
0.031998504,
0.002095915,
-0.00042105434,
-0.0012180065,
0.005041261,
-0.0045335554,
0.011136989,
-0.011006808,
0.0016061087,
-0.0016956083,
0.0031471269,
0.008084243,
-0.012861888,
0.019839592,
0.011436406,
0.0053829867,
-0.012237019,
-0.036034115,
-0.014345952,
0.013512793,
0.016962592,
0.016962592,
0.021805326,
-0.00025141216,
0.00025710757,
0.024239711,
0.012705671,
-0.025541523,
0.02068577,
0.016988628,
-0.00052153785,
-0.0009348627,
0.008032171,
-0.00597531,
0.0064211804,
-0.002590603,
0.0033179896,
-0.043324254,
-0.0009039447,
-0.019735448,
0.002226096,
-0.012822834,
0.027988926,
0.035851862,
0.01298556,
-0.011514514,
0.0056954212,
0.030566512,
-0.0038631228,
-0.024981745,
-0.030202005,
0.005138897,
-0.018876253,
0.015114021,
0.004823208,
-0.015413437,
0.0044554467,
-0.004172303,
-0.0023774314,
0.0010398212,
0.00728363,
0.0058288565,
0.021336675,
0.010479575,
0.01202873,
-0.0050965883,
-0.013343558,
0.015882088,
0.009457653,
-0.018498728,
0.025398323,
-0.008741658,
0.0009877487,
-0.0047939173,
-0.011052371,
-0.0343678,
0.0030185732,
-0.0075830463,
0.011208588,
-0.029290738,
-0.0027940108,
-0.01106539,
0.019488104,
-0.013799191,
0.0077197365,
-0.008839293,
-0.020373335,
-0.039601076,
-0.025515486,
0.018641926,
0.0067108334,
-0.027572347,
-0.017743677,
0.0036515784,
0.004081176,
-0.000014124136,
0.0032626626,
-0.011618659,
0.018980397,
0.022703575,
-0.023133174,
-0.0144761335,
-0.008637513,
-0.016389795,
0.012939997,
-0.020659734,
-0.004390356,
-0.026114319,
-0.00419183,
-0.008129807,
0.012204474,
-0.012640581,
0.019501122,
0.003394471,
-0.017431242,
-0.0010162259,
0.008559404,
0.0027549565,
0.0077262456,
-0.0011805794,
-0.015218165,
-0.013070178,
-0.0144370785,
-0.024317821,
-0.0022065688,
-0.018407602,
0.009991396,
-0.009438126,
-0.015283256,
-0.011905057,
0.012113347,
0.015608708,
-0.007641628,
-0.005034752,
0.007251085,
0.03965315,
-0.0095552895,
0.03277959,
0.004068158,
-0.008286024,
-0.019162651,
0.000391967,
0.031842284,
0.004839481,
-0.01003045,
0.0062877447,
-0.011429897,
0.0001517423,
-0.016858445,
0.0027256657,
0.0022407414,
0.027233876,
-0.022677539,
-0.010434011,
-0.040278018,
0.016129432,
-0.031035163,
-0.008670058,
-0.017639533,
-0.007888972,
-0.010642301,
0.0120222205,
0.015699835,
-0.013031123,
0.05189017,
-0.025958102,
-0.0144500965,
0.0042146114,
-0.016311686,
0.019058507,
-0.0010154123,
0.012217492,
-0.035539426,
-0.007036286,
-0.0052788416,
-0.0089369295,
0.0012977424,
-0.016676193,
0.043168038,
0.015478527,
0.022586413,
0.00432852,
0.00762861,
-0.0015060321,
0.004178812,
0.009639907,
-0.010596738,
0.008129807,
-0.007791336,
0.027572347,
0.019396977,
-0.014202753,
-0.0033814528,
-0.00921031,
0.02232605,
0.012490872,
-0.01614245,
-0.012373709,
-0.012510399,
-0.016689211,
-0.015634745,
-0.00017838873,
-0.012855379,
0.006232418,
-0.026127337,
-0.03251923,
0.0048427354,
0.014098608,
0.028353434,
-0.008409696,
0.024968727,
-0.038455483,
0.033690855,
0.022755649,
0.003957504,
-0.0015385774,
-0.02733802,
0.011774876,
-0.0067563965,
-0.02136271,
0.007622101,
0.009633398,
-0.009366527,
-0.0048557534,
0.005627076,
0.0082990425,
-0.020230135,
-0.0064699985,
-0.0031210908,
-0.0034855977,
-0.014593296,
-0.017626515,
-0.008116788,
-0.026192429,
-0.023679934,
0.00859195,
-0.017769713,
0.008292533,
-0.00008146486,
-0.01167724,
0.014059554,
-0.018355528,
0.014541224,
-0.011670731,
0.03194643,
0.0061543095,
0.010023941,
-0.026921442,
0.007062322,
0.0069972314,
-0.00838366,
0.03915846,
-0.010010923,
-0.009041074,
-0.00913871,
-0.00067978917,
0.008045189,
-0.026114319,
-0.028093072,
0.022924883,
-0.0020210608,
-0.005295114,
-0.0051649334,
0.010141104,
-0.023745025,
-0.009561799,
-0.0005756444,
-0.011742331,
-0.0067498875,
-0.000768475,
-0.026648061,
0.022703575,
-0.015035911,
-0.003716669,
-0.032258864,
-0.02741613,
0.018472692,
-0.0322849,
0.0045107733,
-0.008357624,
-0.0038566138,
0.031035163,
-0.014189735,
-0.008617986,
0.01758746,
0.022091724,
0.017405206,
-0.024903636,
-0.006177091,
0.03499267,
0.012855379,
-0.013577884,
0.051577732,
0.026153374,
0.0153874,
0.008578931,
-0.0076937,
-0.04100703,
-0.009119183,
0.0042081024,
0.01573889,
0.004211357,
-0.03759629,
0.026973514,
-0.020047883,
0.0021121877,
-0.016090378,
-0.033768967,
0.01256898,
-0.040434234,
0.008168861,
-0.003142245,
0.0007578978,
0.024382912,
-0.003628797,
0.010902663,
-0.01779575,
0.030254077,
-0.02830136,
0.021766271,
-0.011462442,
0.008097261,
-0.016532993,
0.01635074,
-0.031633995,
-0.013408649,
0.023927277,
-0.0041625393,
-0.034550052,
-0.025320215,
0.004543319,
0.018863235,
0.008748167,
0.0019217978,
0.04046027,
-0.018720036,
0.0019315614,
-0.010089031,
-0.00013282536,
0.018316474,
-0.019748466,
0.02871794,
0.019071525,
0.014033518,
0.008644022,
-0.013395631,
-0.030332185,
0.019006433,
0.0022928137,
-0.015309292,
-0.004204848,
0.030175969,
-0.048948076,
0.0035734698,
-0.015790962,
-0.014319916,
-0.010707391,
-0.004240648,
0.0020910332,
-0.0072315577,
-0.037804577,
-0.0067108334,
-0.0007546433,
-0.0040356126,
-0.013083196,
-0.009581326,
-0.0073487204,
-0.01202873,
-0.032753553,
-0.00092103094,
-0.05373874,
0.018863235,
0.017496334,
-0.039601076,
-0.0067303604,
0.014944785,
-0.019709412,
-0.01456726,
-0.010212704,
0.008194897,
-0.0042308844,
0.009594344,
0.0038989226,
0.018121203,
0.006505798,
-0.006645743,
-0.024161603,
-0.03236301,
0.012315128,
-0.03319617,
0.033274278,
-0.0004849244,
-0.022807721,
-0.026439771,
0.04376687,
-0.0006745006,
-0.014241807,
0.017704623,
-0.016793355,
0.013063668,
-0.02783271,
0.014385006,
0.01532231,
-0.0068475236,
0.035982043,
-0.022859793,
0.01737917,
0.022859793,
0.0057702754,
-0.019774502,
-0.0020194335,
0.0013311013,
0.0089239115,
0.007875954,
-0.008110279,
-0.026973514,
0.013747119,
0.0011154889,
0.0073096664,
0.0063202903,
0.008136316,
-0.0033131079,
0.012035239,
-0.028041,
-0.018511746,
-0.014163699,
-0.018355528,
0.0138642825,
0.012061275,
0.018980397,
-0.012484363,
-0.010499102,
-0.0126015255,
-0.008500823,
0.0011732568,
-0.023068083,
-0.018811163,
-0.0353051,
0.024708364,
0.0075700283,
-0.016637139,
-0.028249288,
0.006486271,
-0.01230211,
0.024552146,
-0.016025288,
0.02569774,
-0.004995698,
-0.011234625,
-0.011579605,
-0.007888972,
-0.009015038,
0.010141104,
-0.051499624,
-0.00083397236,
0.02213078,
0.1886063,
-0.028900193,
0.0044717193,
-0.00088279025,
0.0033456532,
0.018264402,
0.013343558,
0.011260661,
-0.031998504,
0.004113721,
0.024109531,
0.003171536,
-0.029915607,
0.00018337222,
-0.00031060385,
-0.0078369,
-0.03470627,
-0.008604968,
-0.014541224,
-0.023484662,
0.005496895,
-0.01195062,
0.0060696914,
-0.020828968,
0.034940593,
-0.0034888522,
-0.021531947,
0.0041592848,
0.020581625,
0.013642974,
-0.005532695,
-0.0033619257,
-0.0039802855,
0.01938396,
0.0069842134,
0.009444635,
-0.0021610055,
0.006684797,
0.0011236252,
-0.00091777643,
0.014996857,
0.021375729,
-0.009991396,
-0.03251923,
-0.00046499044,
-0.006541598,
0.0021740235,
-0.009060602,
-0.018941343,
0.023549752,
-0.03764836,
-0.015153075,
0.017418224,
0.017196918,
-0.0067238514,
-0.0074919197,
0.007862936,
0.03483645,
0.01620754,
0.029368846,
-0.01318734,
0.014176717,
-0.0151010025,
0.0054871314,
-0.023484662,
0.0325713,
0.0024913398,
-0.025059853,
-0.0021984326,
-0.019436032,
0.013499775,
-0.011521023,
-0.0055001494,
0.007993117,
-0.016051324,
-0.0017899895,
0.031009126,
0.003937977,
0.0007033845,
0.034107435,
0.012868397,
-0.025619632,
-0.045094717,
-0.0003813898,
-0.011371315,
-0.025528505,
0.019826574,
0.004995698,
-0.012321637,
-0.01223051,
-0.003054373,
0.01484064,
-0.022898847,
-0.009379545,
-0.003420507,
-0.0045595914,
-0.007042795,
-0.010342885,
0.0089434385,
-0.022286996,
-0.031816248,
0.078785576,
-0.0029209375,
0.022000598,
-0.012555962,
0.0077718087,
-0.0033489077,
0.0024815763,
-0.004058394,
0.008670058,
0.009880742,
-0.024786472,
0.012061275,
-0.02239114,
-0.002226096,
0.022703575,
0.033690855,
-0.006336563,
0.016806373,
-0.010844082,
-0.005477368,
-0.008513841,
0.014072572,
-0.002689866,
-0.010876627,
0.009399072,
-0.0048264624,
-0.01614245,
-0.0120157115,
-0.033690855,
0.0029551098,
-0.01771764,
-0.009991396,
0.0065643797,
0.004995698,
-0.029525062,
-0.0058972016,
0.009399072,
-0.004204848,
0.026153374,
0.003524652,
0.009802633,
-0.0007440661,
0.0020926604,
0.012445308,
-0.022313032,
0.013551848,
0.015140057,
-0.00011746806,
0.025346251,
-0.024304803,
0.0017037445,
-0.017978003,
-0.009783106,
0.029394882,
-0.018563818,
-0.022156816,
-0.04246506,
0.005138897,
0.005718203,
-0.022625467,
0.019488104,
0.020646716,
-0.00969198,
0.00044017468,
0.008006135,
-0.16340326,
0.012887924,
0.0088913655,
-0.021805326,
0.02741613,
-0.003993304,
0.018524764,
0.010225722,
-0.0041365027,
-0.0011577978,
0.02686937,
-0.0020064155,
-0.05022385,
-0.013291486,
-0.004038867,
-0.0066620153,
-0.010368921,
0.039627112,
0.0005044516,
0.020698788,
0.03395122,
-0.0107659735,
0.0045107733,
-0.017340116,
-0.0120157115,
0.012887924,
-0.006430944,
-0.007537483,
-0.018641926,
0.0021252057,
-0.0021431055,
0.024903636,
0.02041239,
0.02164911,
0.014072572,
-0.008735148,
-0.0056954212,
-0.024031423,
-0.0030625092,
0.026791262,
0.014957803,
0.035539426,
0.005584767,
0.008357624,
-0.016884483,
0.027311984,
0.019019451,
0.0060436553,
0.03470627,
0.005187715,
0.007003741,
-0.017340116,
0.012679635,
0.010290813,
0.02012599,
0.012263055,
0.007804354,
0.01525722,
-0.0025889757,
-0.020204099,
-0.0144761335,
-0.019071525,
0.020855004,
-0.001121998,
0.013324031,
-0.016324705,
-0.023302408,
-0.012686144,
-0.024135567,
-0.005379732,
-0.021818345,
-0.043949123,
0.002392077,
-0.035018705,
0.026817298,
-0.0006822301,
-0.01771764,
0.030931018,
0.015999252,
0.0057084393,
0.0101541225,
-0.013734101,
-0.022313032,
-0.014267843,
-0.0002316816,
0.00050079025,
0.015022893,
0.032597337,
-0.029837497,
-0.0092754,
0.01628565,
-0.03475834,
-0.0030592547,
-0.0013237785,
0.00046377,
0.013421667,
0.014684423,
-0.00018571141,
-0.0011797658,
0.01305065,
0.032727517,
-0.0044261557,
-0.00046173594,
0.01628565,
0.026322609,
-0.0033228714,
-0.048010774,
-0.008233951,
0.03921053,
-0.023393536,
-0.008735148,
-0.008735148,
-0.016428849,
0.025085889,
-0.0033065989,
-0.0013123878,
0.018303456,
-0.021805326,
0.011735822,
-0.030800838,
0.0651426,
0.0052723326,
-0.0034302708,
0.027051622,
-0.0034693251,
-0.021102348,
-0.12018315,
-0.046005983,
-0.0041950843,
0.02246925,
0.003104818,
0.029316774,
0.015725872,
0.0025401579,
-0.0032805626,
0.025150979,
-0.011039353,
0.006460235,
-0.004204848,
-0.008097261,
0.011143498,
0.009223328,
0.02686937,
-0.0069907224,
-0.015296274,
0.03382104,
-0.0028005198,
-0.023107138,
0.01752237,
-0.022352086,
-0.0031861812,
0.020881042,
-0.021323657,
0.012744725,
-0.0053276597,
0.006808469,
0.00021235785,
-0.0069777044,
0.025476431,
0.0022407414,
-0.0325713,
-0.02529418,
-0.0049175895,
0.010915682,
0.026947478,
-0.0010796891,
0.017053718,
-0.0060794554,
-0.0033521622,
0.0005439127,
-0.03538321,
0.017743677,
-0.016676193,
-0.006795451,
0.010323358,
-0.004839481,
-0.013525811,
-0.02089406,
-0.023862187,
-0.008631004,
0.023536734,
-0.018355528,
0.017821787,
0.028978303,
-0.02817118,
0.007667664,
0.0029762643,
0.01731408,
-0.0199177,
0.009945832,
0.03673709,
-0.009490198,
-0.0007802727,
-0.030826874,
0.01525722,
-0.019123597,
-0.0055066585,
0.029212628,
0.0075830463,
0.005477368,
-0.011618659,
0.012191456,
-0.018537782,
-0.02479949,
0.010707391,
-0.03592997,
0.0017151354,
-0.025229089,
0.02425273,
-0.0072380668,
0.005767021,
0.008058207,
0.018199312,
0.00969198,
-0.006512307,
0.00062364864,
-0.015309292,
0.024994763,
0.00852035,
-0.0031406179,
-0.023523716,
0.0033651802,
0.0005207242,
-0.011071899,
0.040980995,
0.0313476,
-0.0075505013,
-0.019201705,
-0.059935357,
0.01256898,
-0.011859494,
-0.0017867349,
-0.018993415,
-0.0265309,
0.012907451,
-0.020399371,
0.006795451,
-0.015908124,
-0.037127636,
0.01793895,
0.0014173462,
0.0051454064,
-0.019943736,
-0.018915307,
0.030123895,
0.022078706,
0.015986234,
0.029186592,
0.0046409545,
0.0062812357,
-0.00034559003,
-0.0032821898,
-0.015179111,
0.00628449,
-0.011254152,
0.02349768,
-0.0061120004,
0.0005435059,
-0.00824046,
-0.023393536,
-0.005767021,
0.018667962,
-0.009301436,
-0.017496334,
0.020243153,
0.021479873,
0.018433638,
0.02452611,
-0.013128759,
-0.020464461,
0.012666617,
0.011371315,
0.010752955,
-0.010687864,
0.002981146,
-0.021271585,
0.023185246,
-0.0066620153,
0.017769713,
0.021466855,
0.016090378,
-0.01806913,
-0.03462816,
0.015192129,
0.0020568606,
-0.024565164,
-0.017860841,
-0.03814305,
0.041059103,
0.008214424,
0.013616938,
-0.00066107564,
0.015374382,
-0.019735448,
-0.018524764,
-0.0059883283,
0.029655244,
-0.03592997,
-0.023640878,
0.014176717,
0.0014604687,
0.013695047,
0.0056173126,
-0.014332934,
-0.023536734,
-0.0036157789,
-0.0095487805,
0.0011423387,
0.016819391,
0.0022033143,
-0.026166392,
0.026517881,
0.023614842,
-0.001292047,
-0.004113721,
0.0008478041,
0.015504563,
0.015491545,
-0.0052593146,
0.02837947,
0.002369295,
0.013369594,
0.015999252,
0.007830391,
0.011859494,
-0.008377151,
0.0015825134,
0.021206494,
0.014293879,
0.016858445,
-0.0020487243,
0.012822834,
-0.0047646267,
-0.0013807327,
-0.016858445,
-0.024812508,
-0.0061738365,
-0.019266795,
0.011918075,
-0.0025336489,
-0.00082380197,
0.0007469138,
-0.017418224,
0.014762531,
-0.015400419,
0.017626515,
-0.002584094,
0.0047353357,
0.025945084,
0.014046536,
0.0017330353,
-0.012282582,
0.005906965,
0.013291486,
0.03566961,
-0.028014963,
0.015543617,
-0.010505611,
0.018785127,
-0.007199012,
-0.025124943,
-0.01806913,
-0.009425108,
-0.011553569,
0.01147546,
0.012822834,
-0.0083120605,
0.08493012,
0.01023874,
-0.0065090526,
-0.010635792,
0.022365104,
0.03790872,
-0.0044489377,
0.01195062,
-0.008416205,
-0.0041462667,
0.019045489,
-0.030800838,
-0.0056498577,
-0.05324405,
-0.039262604,
0.0026133847,
-0.0044391737,
0.014580278,
-0.0132263955,
-0.016233576,
0.01965734,
-0.011215098,
-0.002356277,
0.010277794,
-0.044131376,
-0.007264103,
0.057175517,
-0.004416392,
0.017613497,
-0.03579979,
-0.0026443026,
0.011631677,
-0.0071469396,
0.009522744,
0.018121203,
-0.024903636,
-0.012529926,
-0.010368921,
0.022755649,
0.014749513,
0.006238927,
0.015074966,
-0.02390124,
-0.018693998,
0.0016353995,
-0.0053081326,
-0.024513092,
-0.0056563667,
-0.03126949
] |
Diamond-Blackfan anemia (DBA) is a congenital erythroid aplasia characterized as a normochromic macrocytic anemia with a selective deficiency in red blood cell precursors in otherwise normocellular bone marrow. In 40% of DBA patients, various physical anomalies are also present. Currently two genes are associated with the DBA phenotype--the ribosomal protein (RP) S19 mutated in 25% of DBA patients and RPS24 mutated in approximately 1.4% of DBA patients. Here we report the identification of a mutation in yet another ribosomal protein, RPS | [
-0.025719926,
-0.01831248,
0.015998486,
-0.039683692,
-0.052796334,
0.03494931,
-0.032954488,
0.004724407,
-0.040242244,
-0.0091096945,
-0.004501652,
-0.009701492,
0.014868085,
0.0025201272,
-0.0142563395,
0.0037968142,
0.025919408,
0.0056187534,
0.0065662945,
-0.0059346003,
-0.029948952,
0.030268123,
-0.012766872,
-0.010984829,
-0.0005535636,
-0.006948636,
0.022780886,
-0.018152894,
-0.010885088,
0.0017770554,
0.026145488,
-0.022701094,
0.021078637,
-0.005937925,
0.0063535133,
0.007979294,
-0.011530081,
-0.00046213414,
0.033752415,
0.008225323,
0.009801233,
0.017620942,
-0.009668245,
-0.009103045,
-0.0036106308,
-0.0060110684,
0.0046778615,
-0.0050502284,
-0.029230816,
-0.010725502,
0.023685206,
-0.00056395325,
-0.0018152895,
0.00076177326,
0.0026165438,
0.023312839,
-0.003697073,
0.020799361,
-0.018299183,
0.0067026075,
0.0017637566,
-0.0015110789,
-0.018458769,
-0.0029905732,
-0.020786062,
0.0040328684,
0.032422535,
0.02045359,
0.014429225,
0.015772406,
0.038593188,
0.011802707,
-0.0006204733,
-0.00015522221,
0.009887676,
-0.02962978,
-0.024443239,
-0.0029722871,
-0.0052663344,
-0.005868106,
0.015958589,
0.0061174594,
-0.009621699,
0.018019907,
0.012414453,
-0.012175074,
-0.046652276,
0.0052463864,
-0.0045348993,
0.0025068284,
0.011124467,
0.016224565,
0.023153253,
0.0020845907,
-0.017607644,
-0.005236412,
0.028326496,
0.028007325,
0.0031069377,
-0.024921997,
-0.0029274037,
0.018977422,
-0.022528209,
-0.0072345603,
0.0075603817,
0.013551502,
-0.008537845,
0.019482778,
0.0053095557,
-0.013272227,
-0.010805295,
0.046678875,
0.0327683,
-0.04455106,
0.026491258,
-0.00052530353,
0.007600278,
-0.015240452,
-0.010333186,
-0.0039630495,
0.025959305,
0.035773836,
0.015546326,
-0.025121478,
0.0052064895,
-0.002934053,
-0.040534817,
-0.016956002,
-0.005711845,
0.0064931507,
0.027448773,
0.017235275,
0.01946948,
0.0062005767,
-0.01617137,
-0.012627234,
-0.04513621,
-0.0118825,
-0.021145131,
-0.04037523,
0.012733624,
0.029948952,
-0.027235992,
-0.003234939,
-0.012826716,
0.02138451,
-0.009927573,
0.0024187237,
0.0025999201,
-0.020413695,
0.014974476,
0.0045980685,
0.0003040028,
-0.02478901,
0.0007222924,
0.019841846,
0.01198889,
0.020839257,
0.001614976,
-0.016676726,
-0.010585864,
0.013671191,
-0.008059087,
-0.014761695,
-0.001572586,
0.02227553,
-0.030613894,
-0.011290702,
0.002576647,
-0.02275429,
-0.005642026,
-0.00081289065,
-0.031917177,
0.013425163,
-0.012121879,
-0.0026847,
-0.0064931507,
0.0055023883,
-0.03404499,
-0.0192301,
0.017554449,
0.009621699,
0.012693727,
0.0002653531,
0.0071281698,
0.013431813,
0.039098542,
-0.0077532143,
0.02216914,
-0.0030487555,
0.0090897465,
0.01754115,
0.017035794,
-0.020254109,
-0.6332368,
-0.018126298,
-0.0010630748,
-0.01856516,
0.017088989,
0.013425163,
0.010718852,
-0.026331672,
-0.00464129,
-0.020280708,
0.009701492,
-0.004874019,
0.015439935,
-0.022980368,
0.009521958,
-0.014615408,
0.018059803,
-0.004977085,
0.013897272,
-0.012281464,
-0.039311323,
-0.006516424,
-0.022009553,
-0.01164977,
-0.011510133,
0.0066361134,
0.016849611,
-0.006021043,
0.017088989,
0.016211268,
-0.021224923,
0.03348644,
0.019841846,
-0.014429225,
0.052902725,
0.00413261,
0.011809356,
0.013132589,
0.0032482378,
0.0090897465,
0.0018285883,
0.027342383,
0.035135493,
0.0067159063,
-0.017049093,
0.021291418,
0.008843718,
0.0125540905,
0.012301412,
-0.021849968,
0.009934221,
0.00047584856,
-0.024230458,
0.011968941,
0.008524546,
0.0080723865,
0.015320245,
-0.0067258803,
0.017035794,
-0.0016349242,
-0.01143034,
0.025320962,
-0.0034277719,
-0.018751342,
0.009548556,
0.0024586201,
-0.005395998,
0.027980726,
0.0000707539,
-0.0053328285,
0.013471709,
0.014149949,
-0.012547441,
0.019150307,
0.026145488,
-0.0052064895,
0.015519728,
0.037688866,
-0.03686434,
0.016729921,
-0.0010107106,
0.009535257,
-0.010964881,
-0.009016603,
0.04550858,
0.016463945,
-0.029443597,
0.016836312,
-0.014070156,
-0.01980195,
0.005645351,
0.011038024,
-0.013990363,
-0.039337922,
-0.02046689,
0.009209435,
0.019269997,
-0.01153673,
0.009096396,
-0.013385267,
-0.040721,
-0.011782758,
-0.010838542,
-0.007567031,
0.02093235,
-0.00690209,
-0.042316858,
-0.012746923,
0.042370055,
-0.02736898,
0.0070084804,
0.0004812512,
-0.008896913,
0.0017438084,
0.0024818932,
-0.016796416,
0.006107485,
0.0039663743,
-0.007168066,
-0.02194306,
0.0068056732,
0.022115944,
0.021291418,
-0.016610231,
-0.010845191,
0.010539318,
-0.0016748207,
-0.004345391,
-0.0041791555,
-0.009249332,
0.0018851083,
0.009315826,
0.021451004,
-0.017554449,
0.04346056,
-0.021756876,
0.023911286,
-0.0013282201,
-0.0037236707,
-0.018578457,
-0.005007007,
0.0007962671,
-0.010393031,
0.025347559,
-0.009169539,
0.004830798,
-0.025467249,
-0.0059113274,
-0.0018086401,
0.009136292,
-0.002335606,
0.008398208,
-0.02885845,
0.032528926,
0.0032100037,
-0.020147718,
-0.018192792,
-0.026318373,
-0.0108318925,
-0.003196705,
0.008238622,
0.0033446543,
0.0028193507,
-0.008790523,
0.003178419,
-0.017807126,
-0.0057617156,
0.024150664,
-0.0062737204,
-0.01617137,
-0.017155483,
-0.0012176736,
0.011164363,
-0.0069286874,
-0.0114569375,
-0.013172486,
-0.005971172,
-0.005585506,
-0.018684847,
-0.009508659,
0.008085685,
0.0015784042,
-0.0073542497,
-0.014349432,
0.044152096,
0.02667744,
0.022714391,
0.001968226,
0.010093807,
0.016264463,
-0.04311479,
0.04037523,
-0.032050166,
-0.0063402145,
0.0022159165,
-0.016357554,
-0.013365318,
0.015599521,
-0.015945291,
0.03939112,
0.012414453,
-0.026092293,
0.025041686,
-0.0029041308,
0.021411108,
-0.03098626,
-0.012381205,
0.0022209038,
0.00002051967,
0.012534142,
-0.011729563,
0.010918335,
0.015892096,
0.013564801,
0.0035108896,
0.012075332,
-0.004468405,
-0.00086608593,
-0.009940871,
-0.01764754,
-0.008943459,
0.011802707,
0.0142563395,
-0.003319719,
0.0053793746,
-0.026850326,
0.018977422,
0.038486797,
0.008172127,
-0.021677084,
-0.00065372034,
0.015825601,
0.0030487555,
-0.006040991,
-0.026730636,
0.0031950425,
-0.0035707343,
-0.015014373,
0.031996973,
-0.010924984,
-0.018285884,
-0.0009350736,
0.008783873,
0.009555206,
0.010532669,
-0.0049072662,
0.0061906027,
0.025028387,
-0.035454664,
0.021863267,
-0.0327949,
0.011137765,
-0.026398167,
-0.0017221977,
-0.01006721,
-0.003042106,
0.01335202,
0.025041686,
0.009468763,
0.016357554,
0.030933065,
0.006469878,
-0.0054558427,
-0.014123351,
-0.002387139,
0.0059113274,
0.008338363,
-0.0077997604,
0.002980599,
0.007613577,
-0.02352562,
-0.012500895,
0.013192434,
-0.036172803,
0.00078379945,
-0.0112441555,
-0.0017604319,
0.010785347,
0.022102647,
-0.0064333063,
0.0042556236,
-0.04130615,
0.011569977,
0.02896484,
-0.014149949,
-0.006536372,
0.005947899,
0.02387139,
-0.0073343017,
0.041598722,
0.011782758,
0.017035794,
0.009196137,
0.016357554,
-0.003324706,
-0.010000716,
0.018179493,
-0.0014437536,
0.010346485,
0.0024835553,
-0.0015227154,
0.0019150306,
-0.02182337,
-0.014655304,
0.050030176,
-0.0040661157,
0.00308034,
-0.00080291653,
0.009661596,
-0.019283295,
-0.022780886,
-0.037901647,
-0.011563328,
0.012015488,
0.011816005,
-0.0035574355,
-0.021238223,
0.023326138,
0.027847739,
-0.002166046,
-0.014296236,
-0.04082739,
0.008125582,
0.007793111,
0.031305432,
0.009315826,
-0.022076048,
0.0031534836,
-0.012381205,
0.03359283,
0.0059977695,
-0.00859769,
0.03673135,
0.015931992,
0.0024004378,
-0.00616068,
0.025320962,
0.011709615,
-0.008983356,
0.030454308,
-0.010978179,
-0.031411823,
-0.014974476,
0.018046504,
-0.011137765,
0.0059911204,
0.01776723,
0.033646025,
0.019629065,
0.007600278,
0.003766892,
-0.02657105,
0.01538674,
-0.0040661157,
-0.013977065,
0.001341519,
-0.013318772,
0.014907982,
0.028140312,
-0.0046645626,
0.011503483,
-0.0056353766,
0.0056121037,
0.008305116,
0.014189846,
0.011975591,
0.015639417,
-0.008491299,
0.008351661,
-0.021876566,
-0.02682373,
-0.010213497,
0.0013240642,
-0.025866212,
0.036039814,
0.0072212615,
-0.014402627,
-0.007912801,
0.023113357,
0.015506429,
-0.0024453213,
-0.014748396,
0.011264104,
-0.0090897465,
-0.0054824403,
-0.009541906,
0.016995898,
0.010419629,
-0.008384909,
0.0018369001,
-0.027900934,
-0.010472824,
-0.0146287065,
-0.020639775,
-0.025267767,
-0.0018036531,
-0.00344772,
0.01855186,
0.014376029,
-0.0054757907,
0.012035436,
-0.021876566,
-0.010931633,
0.0046878355,
-0.02806052,
-0.021451004,
0.020227512,
-0.017168783,
-0.013092693,
0.015652716,
0.010718852,
-0.020107822,
-0.033699222,
0.026743935,
0.0047643036,
0.0035142144,
0.018631652,
0.008172127,
-0.0020446943,
-0.0031019507,
0.016237864,
0.030720284,
-0.015147361,
-0.00916289,
-0.0012401154,
-0.0091296425,
-0.022927172,
-0.006808998,
0.009216085,
-0.0076601226,
-0.02340593,
-0.0025134778,
0.003075353,
-0.013431813,
-0.014415925,
-0.007680071,
-0.0014420913,
0.008411506,
0.023618711,
0.0122216195,
0.013578099,
0.021078637,
0.0028442862,
-0.0044650803,
0.018299183,
-0.016596932,
0.03678455,
0.014243041,
-0.007321003,
0.029390402,
0.006606191,
-0.028991437,
-0.04923225,
-0.013205732,
0.0043753134,
0.021783475,
-0.012693727,
-0.010984829,
-0.027634956,
-0.008404857,
0.0051300214,
0.0076401746,
-0.0028758708,
-0.019216802,
0.0034177979,
0.02883185,
0.021903163,
-0.0026331672,
0.012647182,
-0.024004377,
-0.008511247,
-0.012128527,
-0.003160133,
0.011337248,
-0.026118891,
0.009122994,
0.009169539,
0.007852956,
0.0072678076,
-0.015187257,
0.005349452,
-0.017820425,
0.036093008,
0.013937168,
0.019921638,
0.0072944053,
0.038646385,
0.020054627,
0.007892853,
0.008418156,
-0.009455464,
0.0016690025,
0.0013224018,
0.010246744,
-0.0006474865,
0.016224565,
0.010253393,
-0.025719926,
0.038141027,
0.031863984,
-0.013963765,
-0.023765,
-0.0040927134,
-0.04284881,
-0.018857732,
0.010333186,
-0.009668245,
0.018392274,
-0.03447055,
-0.0058182357,
0.017980011,
-0.003833386,
-0.01300625,
-0.03683774,
0.024257055,
0.009149591,
0.038619787,
0.00724121,
0.02682373,
0.014748396,
-0.031252235,
0.0062504476,
-0.022209037,
0.015027671,
0.021783475,
0.03425777,
0.021211624,
-0.035614252,
0.034098186,
0.003550786,
-0.024403343,
-0.03234274,
-0.0025201272,
-0.013485008,
-0.026172087,
-0.026211983,
-0.029284012,
-0.037183512,
0.0027112977,
0.016650127,
-0.013205732,
0.028805254,
-0.0038699578,
-0.017102288,
0.011909097,
-0.008883615,
-0.007387497,
-0.024735814,
0.024496434,
0.014402627,
-0.0226346,
-0.019323193,
0.009608401,
0.0150010735,
-0.018365676,
0.026850326,
0.015333544,
-0.044604257,
-0.014163248,
0.010924984,
0.007114871,
-0.012520843,
-0.02183667,
0.022022853,
-0.024137367,
0.028220106,
-0.0023006967,
-0.007613577,
-0.011137765,
0.004501652,
-0.027634956,
-0.0030221578,
0.0064299814,
-0.017807126,
-0.022661196,
0.003338005,
-0.007859605,
0.014801592,
0.0023888014,
-0.009827831,
-0.01289986,
-0.0045548473,
-0.019828547,
0.015293648,
0.011603224,
0.042343456,
0.004006271,
0.015905393,
-0.0058182357,
0.00014566368,
0.024257055,
-0.012175074,
-0.02183667,
0.03766227,
-0.010253393,
-0.0014179872,
0.009648297,
0.0028592471,
0.0071215206,
0.029151022,
-0.0037635672,
-0.023339437,
-0.024855502,
0.002109526,
0.007892853,
0.01448242,
-0.011609874,
0.026624246,
-0.028326496,
-0.009455464,
-0.015253752,
-0.03335345,
0.018192792,
-0.040109254,
-0.023352735,
-0.006808998,
0.008025841,
0.0180997,
0.002834312,
-0.011031374,
-0.00034784738,
0.014136651,
-0.0014869748,
0.002425373,
0.010206847,
-0.0107521,
-0.010652359,
0.00025974266,
-0.0226213,
-0.01164977,
0.0013639607,
-0.009455464,
0.0018385624,
-0.029044632,
-0.0044285087,
-0.013830777,
0.0007048377,
-0.0139238695,
0.011350547,
-0.011975591,
0.027063107,
-0.0066460874,
-0.019190203,
0.014003662,
-0.0027428826,
0.01776723,
0.0060110684,
0.020041328,
-0.021344613,
-0.010791996,
-0.004724407,
-0.01028664,
-0.005213139,
-0.017155483,
-0.015666015,
0.029177621,
-0.009016603,
-0.0005951224,
-0.021331314,
0.010539318,
-0.017727332,
0.024257055,
0.027023211,
0.0016133136,
0.003653852,
0.013657892,
-0.005608779,
0.040561415,
-0.0037469438,
0.013072744,
0.012607286,
-0.016557036,
-0.031970374,
0.014548914,
-0.009369021,
0.030161733,
0.019815248,
-0.0058980286,
-0.019974833,
-0.005382699,
-0.033912003,
-0.012268165,
0.0064067086,
0.03521529,
0.011543379,
0.009056499,
0.025586938,
0.017368264,
-0.006755803,
0.0059445743,
-0.021796772,
-0.010373083,
0.009448814,
0.008311765,
0.024137367,
-0.015666015,
-0.019762052,
-0.02387139,
0.016783116,
0.0053461273,
-0.00072104565,
0.002787766,
-0.0065529956,
-0.0010447889,
0.003986323,
0.019256698,
-0.014828189,
0.0027528566,
0.007340951,
-0.014801592,
-0.018112998,
0.014429225,
0.010885088,
-0.021078637,
0.023126656,
0.029496793,
0.002924079,
-0.0014778319,
-0.01526705,
0.003800139,
0.008384909,
-0.014123351,
0.010452876,
0.018724745,
-0.005020306,
0.0226213,
0.006320266,
-0.013205732,
0.0074805887,
-0.012760222,
-0.010014014,
-0.014655304,
-0.0070417277,
0.000002831195,
0.004943838,
-0.004062791,
0.0006553827,
-0.011004777,
-0.007340951,
-0.02397778,
-0.057876483,
-0.026664143,
0.019855145,
-0.015692612,
0.0030321318,
-0.010512721,
-0.0054059722,
-0.03697073,
0.00006306552,
0.009861078,
0.0158389,
-0.011895798,
-0.012527493,
-0.009621699,
-0.033513036,
-0.010599163,
-0.0071215206,
-0.017900217,
-0.021583991,
0.02058658,
0.1844813,
0.002500179,
-0.017886918,
0.016942702,
-0.023578815,
-0.028565874,
0.0055688825,
-0.006031017,
0.00093008653,
0.011097869,
0.03303428,
-0.005146645,
0.0071547674,
0.0006433306,
0.02045359,
0.009621699,
-0.020214213,
-0.007387497,
-0.029337207,
-0.026318373,
-0.02272769,
0.0008311765,
-0.010466175,
0.025852915,
0.0361994,
-0.00639341,
-0.027182797,
0.016557036,
0.018897628,
-0.0076401746,
-0.0087173795,
-0.01537344,
-0.0056154286,
-0.0019765378,
0.0006046809,
-0.011749512,
0.014096754,
-0.026025798,
-0.015120763,
0.03087987,
-0.02194306,
0.034071587,
-0.01946948,
0.011862551,
-0.025227869,
0.0047909017,
-0.009222735,
-0.029709574,
0.00028363898,
-0.0040095956,
-0.028113715,
0.0042456496,
0.026065696,
0.023485724,
0.0050934497,
-0.017368264,
0.020666372,
0.024496434,
-0.021996256,
-0.009309177,
0.0030337942,
0.02250161,
-0.02274099,
0.019402985,
-0.008039139,
0.027289188,
-0.006549671,
0.012055384,
0.02216914,
-0.026517855,
-0.005372725,
-0.038087834,
-0.018485365,
-0.005881405,
-0.010579214,
-0.039683692,
0.038034637,
0.03526848,
-0.008384909,
0.013225681,
-0.01718208,
0.0035042402,
-0.021517498,
0.016610231,
-0.018352378,
-0.041678514,
-0.0009234371,
0.007174716,
-0.009555206,
-0.04715763,
0.009508659,
-0.0063967346,
-0.008158829,
0.013764283,
0.0068555437,
0.0097945845,
-0.011942344,
0.011157714,
-0.01573251,
-0.029656379,
-0.006908739,
0.083410226,
-0.0026315048,
0.00825192,
-0.014123351,
0.00002935092,
-0.027422175,
0.017820425,
0.016104877,
0.012953055,
-0.0012833365,
-0.008311765,
-0.019841846,
-0.006752478,
0.016823012,
0.0180997,
0.010984829,
-0.027794544,
-0.011683017,
-0.01855186,
0.0025467249,
-0.021756876,
0.02364531,
0.016663427,
-0.01176281,
0.008630937,
0.0101071065,
-0.0066228146,
-0.0111843115,
-0.018591756,
-0.0024503083,
-0.00559548,
0.008351661,
0.0010730489,
0.012175074,
0.033725817,
0.018897628,
-0.012460998,
0.0030404436,
0.007700019,
0.0062604216,
0.011397093,
0.0305341,
-0.0016241189,
-0.018525261,
-0.038513396,
0.030135136,
0.0036039813,
-0.024735814,
-0.008930161,
-0.035374872,
-0.015905393,
-0.019762052,
-0.010120405,
-0.00028405458,
-0.026983315,
-0.015586222,
-0.011390443,
0.0013448437,
0.008331713,
-0.018804537,
0.022661196,
0.02736898,
-0.007374198,
0.0025633483,
0.0024120742,
-0.16777797,
0.010944933,
0.024017677,
-0.034656737,
0.045907542,
-0.0032648614,
0.0032449132,
-0.0031135872,
-0.0047210827,
0.0054092966,
0.010758749,
0.01831248,
-0.011796057,
-0.01946948,
0.01740816,
-0.009688194,
-0.021570694,
0.026717339,
0.033832207,
0.00077715004,
0.018844433,
-0.0016083266,
0.021876566,
-0.03314067,
0.0056254026,
0.007001831,
0.020865856,
-0.00042847148,
-0.007001831,
0.0017255225,
-0.01627776,
-0.016716622,
0.00384336,
-0.009023252,
0.021145131,
-0.02477571,
0.0067691016,
0.0077997604,
0.00053569325,
0.007793111,
-0.0029124424,
0.007633525,
0.0034809674,
-0.007148118,
0.0018152895,
0.06580258,
0.027315784,
0.0038267367,
0.021158429,
-0.0053893486,
0.014229742,
-0.00293904,
0.048673697,
0.012813417,
0.014402627,
0.023991078,
-0.025121478,
0.04093378,
-0.0021909813,
-0.028007325,
-0.013830777,
-0.015572923,
0.004694485,
-0.0029889108,
0.019110411,
-0.0081122825,
-0.0024237107,
0.014921281,
-0.016729921,
-0.002368853,
-0.025081582,
-0.007321003,
-0.009861078,
-0.0192301,
0.015785705,
-0.005439219,
-0.037875053,
0.004262273,
0.006157356,
-0.009415568,
-0.0084846495,
0.015626118,
-0.020373799,
-0.016264463,
-0.011410391,
0.023592114,
0.011855902,
0.015200556,
-0.0069286874,
-0.015852198,
0.018871032,
-0.0475034,
0.0018751342,
-0.006799024,
0.013564801,
0.029230816,
-0.013491658,
-0.019309893,
-0.008318415,
-0.0052530356,
0.024124067,
-0.006040991,
-0.030135136,
0.01571921,
0.03673135,
0.0022242283,
0.00293904,
-0.009887676,
0.0531687,
-0.02126482,
0.0032482378,
0.0041558826,
0.016477244,
0.010818593,
0.0005780833,
0.02907123,
0.0070616757,
-0.007826358,
-0.002764493,
-0.014056858,
0.06415353,
0.01841887,
0.0044584307,
0.041093368,
0.021012142,
-0.015905393,
-0.11181652,
0.0005822391,
-0.0158389,
-0.014522316,
0.0080524385,
-0.00059346005,
-0.0016956001,
0.0005020306,
-0.025387455,
0.013398565,
-0.026504558,
-0.029257413,
0.008637587,
0.0033313555,
0.023086758,
0.020320604,
-0.0028326495,
0.0010946594,
-0.007992594,
0.031119248,
-0.0046778615,
0.0011669719,
-0.017487954,
-0.005156619,
0.0017487954,
-0.018285884,
-0.02670404,
0.009176189,
0.008630937,
0.0029190918,
0.007713318,
-0.01481489,
0.019496076,
-0.007081624,
-0.021025442,
-0.018698147,
-0.018751342,
-0.008810471,
0.04149233,
-0.04468405,
-0.0056353766,
0.016078278,
0.01481489,
0.011503483,
0.016091578,
-0.004504977,
-0.018392274,
0.024456538,
0.014429225,
-0.013431813,
-0.003973024,
-0.024336848,
-0.024709215,
-0.008491299,
0.014016961,
-0.040162448,
0.019748755,
0.031757593,
-0.0077266167,
0.0024037624,
-0.01504097,
-0.00029298972,
0.0034111484,
0.019057214,
0.002829325,
-0.015253752,
-0.01707569,
-0.009149591,
0.035880227,
-0.05159944,
-0.01097153,
0.0026730637,
-0.010379733,
-0.028007325,
-0.007567031,
0.020666372,
-0.03981668,
-0.007959346,
0.015705911,
-0.0248954,
-0.01549313,
-0.014854787,
0.027767945,
-0.021650486,
0.022355324,
0.029470194,
0.0057484168,
-0.017062392,
-0.004548198,
-0.031225638,
-0.0136312945,
0.015160659,
0.0040927134,
-0.026118891,
-0.039683692,
0.016304359,
0.014495718,
-0.016118174,
0.019216802,
-0.0006233824,
-0.030560698,
-0.028193507,
-0.059206367,
0.015745807,
0.018126298,
-0.015985187,
0.0023189825,
-0.028539278,
0.0075005367,
0.00231732,
0.008724029,
0.021557394,
-0.018073102,
0.0080524385,
-0.010220147,
-0.021583991,
-0.023605414,
-0.017461356,
0.012959704,
-0.003507565,
0.024230458,
0.01232801,
-0.016038382,
0.023791596,
0.008863666,
0.006403384,
0.020653075,
-0.026278477,
-0.0035308378,
0.017807126,
-0.014854787,
-0.002584959,
0.016237864,
-0.052849527,
-0.002839299,
-0.0024320225,
-0.028539278,
-0.03135863,
-0.022009553,
0.0031468342,
0.026065696,
0.022687795,
-0.0017487954,
-0.01944288,
0.0037602426,
0.016783116,
-0.0035541109,
0.007600278,
-0.041093368,
0.008657535,
-0.007254509,
-0.000673253,
0.017102288,
-0.0022491636,
0.00063792797,
-0.031624604,
-0.025866212,
-0.009422217,
-0.014176547,
-0.011816005,
-0.002589946,
0.010339836,
0.02635827,
0.00032291206,
0.014136651,
-0.006948636,
-0.0065995418,
0.0007929424,
0.00004480561,
0.009767987,
-0.0002300281,
-0.022355324,
-0.031837385,
0.020200914,
0.016557036,
0.009548556,
0.007148118,
-0.0027761296,
0.003800139,
0.005339478,
0.0027628308,
0.027182797,
0.01650384,
-0.014349432,
-0.014881385,
0.011835953,
0.028193507,
-0.008504598,
-0.009741389,
0.017142184,
-0.004874019,
0.014070156,
-0.027156198,
0.021570694,
0.00881712,
0.031491615,
0.00024582047,
0.0131990835,
-0.0031767567,
-0.00043428974,
0.0060908617,
0.035454664,
-0.007959346,
-0.00045465355,
0.005868106,
-0.029682975,
-0.0066261394,
0.03521529,
-0.009488711,
-0.033406645,
0.0050502284,
-0.0013963765,
0.014987775,
0.016836312,
-0.023086758,
0.014974476,
-0.014602109,
-0.0028476107,
-0.02760836,
0.007633525,
0.001346506,
0.0118492525,
0.010592514,
0.017062392,
0.0015933653,
0.013418513,
0.011131116,
0.0031634578,
0.0073608994,
-0.022155842,
0.018073102,
-0.009974118,
-0.0073808474,
0.004511626,
-0.025294363,
0.0041592075,
-0.002782779,
0.0003148081,
0.03404499,
0.021663785,
0.009455464,
0.078197084,
0.0039298027,
0.0051167225,
0.002171033,
-0.0131990835,
0.0064532543,
0.0049604615,
-0.008019191,
0.0068023484,
-0.022554806,
0.02069297,
-0.021131832,
0.010359784,
-0.010419629,
-0.032954488,
0.042689227,
0.015599521,
-0.0022674496,
-0.0013556489,
0.0039497507,
-0.00938897,
0.0027528566,
0.0080723865,
0.033779014,
-0.009202787,
-0.0035108896,
0.041651916,
0.004807525,
0.008438104,
-0.02976277,
0.0046113674,
-0.019615766,
-0.029204218,
-0.008118932,
0.010160302,
-0.026890222,
-0.014136651,
-0.013318772,
0.006639438,
0.0032598744,
-0.0027412202,
0.0150010735,
-0.023366034,
-0.0010938284,
-0.0015260401,
-0.021012142,
-0.0057085203,
-0.038008038,
-0.0024536331
] |
Breast cancer (BC) is generally classified based on the receptors overexpressed on the cell nucleus, which include hormone receptors such as progesterone (PR) and estrogen (ER), and HER2. Triple-negative breast cancer (TNBC) is a type of cancer that lacks any of these three types of receptor proteins (ER/PR/HER2). Tumor cells exhibit drug resistant phenotypes that decrease the efficacy of chemotherapeutic treatments. Generally, drug resistance has a genetic basis that is caused by an abnormal gene expression, nevertheless, there are several types of drug resistance: efflux pumps reducing the cellular concentration of the drug | [
-0.023478463,
-0.0011997798,
-0.02521761,
-0.027272964,
0.005530351,
0.0050790953,
-0.01024383,
0.008399282,
-0.04010575,
-0.009288617,
0.008287292,
0.0022381616,
-0.008063311,
0.0014089384,
-0.013873638,
0.005704924,
0.041897595,
-0.0048979344,
-0.0136233065,
0.011423023,
-0.022200456,
0.0095653,
-0.004334688,
-0.0108367205,
0.0050099245,
0.008214828,
0.027220262,
-0.043452285,
-0.00055871694,
-0.020882921,
0.0019499509,
0.016759038,
0.00023036267,
-0.000773228,
-0.010151603,
0.013155581,
0.006334047,
0.0032213717,
0.014163495,
0.016903967,
0.004384096,
-0.005592934,
-0.0015283399,
0.022898749,
-0.023821022,
-0.016337426,
0.018959321,
-0.017233351,
-0.014268898,
0.00036582167,
-0.0028508152,
0.0033103053,
-0.0089526465,
-0.008708903,
-0.009275443,
-0.0017457332,
-0.0016098624,
0.036469355,
0.015718186,
-0.013939515,
-0.017193824,
-0.0045718444,
-0.031489074,
0.013768235,
0.0060573644,
0.019236002,
0.0066436674,
0.019986998,
0.0018066692,
-0.001847842,
0.007826155,
0.026535144,
-0.0032823076,
0.0058959667,
0.017365104,
-0.0138077615,
-0.01491449,
0.012648331,
-0.0011413142,
-0.0069631697,
0.0113637345,
-0.025033154,
-0.021897422,
0.0037912054,
0.012042264,
0.0146114575,
-0.004262224,
-0.0059585497,
0.02235856,
-0.018155625,
0.012101554,
0.008069899,
-0.0062879333,
0.013181932,
0.013649656,
0.017523209,
0.0010293238,
0.024861876,
0.0042161103,
-0.017088423,
0.003922959,
0.03565248,
-0.0037944992,
-0.015257049,
-0.007793216,
0.025428414,
-0.013728709,
-0.0028195237,
0.018300554,
-0.006274758,
-0.01013184,
0.04179219,
-0.02368927,
-0.026614197,
0.047931902,
0.013241221,
0.015915817,
-0.0120752035,
0.0033053646,
-0.0028689313,
-0.0036528644,
0.010856484,
0.029117512,
-0.012859136,
0.02751012,
-0.0054743555,
-0.019881595,
-0.0059190234,
0.0021442873,
0.011594303,
0.022964625,
0.006910468,
0.0012022501,
0.01567866,
0.0018231383,
-0.0044137402,
-0.033175517,
-0.01567866,
-0.024440264,
-0.01664046,
-0.0022694531,
0.026627371,
-0.0043149255,
0.020434959,
-0.025164908,
0.014993542,
0.02824794,
0.0056324597,
-0.0052964883,
0.007523122,
-0.007845918,
-0.017483681,
0.017154299,
-0.023030503,
-0.007134449,
0.013175344,
-0.010757669,
0.000893453,
-0.013649656,
-0.01434795,
0.034624804,
0.012819611,
0.024018653,
0.015639134,
0.033175517,
0.026074007,
0.01491449,
0.016087096,
-0.0002076146,
-0.014874964,
0.0020685291,
0.006666724,
-0.01819515,
0.009914447,
-0.006528383,
0.021436285,
-0.014163495,
0.016166147,
-0.023267658,
-0.011732644,
-0.010257006,
0.01590264,
0.022398086,
-0.026811825,
-0.019025197,
0.022437612,
0.02374197,
-0.02159439,
-0.0039657787,
-0.027826328,
-0.012450701,
0.019051548,
-0.00038620227,
-0.014137144,
-0.6387407,
-0.025546992,
-0.0056785736,
0.012628567,
0.017483681,
0.03370253,
0.021383584,
-0.00445656,
-0.030461397,
0.0068116533,
-0.0011487254,
-0.0013965865,
-0.0077998037,
-0.015928991,
-0.011706294,
-0.030355994,
-0.01358378,
-0.008886769,
0.04058006,
0.00027503533,
-0.029987084,
-0.006129829,
-0.027483769,
0.01967079,
0.015612783,
0.008307055,
-0.011119991,
-0.00849151,
0.023834199,
0.024730122,
-0.0191306,
0.03022424,
0.022529839,
-0.0047562993,
0.04893323,
0.00094944827,
0.009710229,
0.014888139,
0.051331144,
0.032305945,
0.0017918468,
0.013544254,
0.018946145,
-0.009986911,
-0.02909116,
0.02866955,
-0.013023828,
-0.00786568,
0.012246483,
0.018801216,
0.0071607996,
0.009769518,
-0.036284897,
0.007088335,
0.018840743,
-0.001284596,
0.025112206,
-0.011021175,
-0.0047661806,
-0.0145192295,
0.011324208,
0.018234678,
-0.0020125338,
-0.033597127,
0.0038307314,
0.005339308,
-0.03212149,
0.012121317,
-0.005550114,
-0.006449331,
0.011284683,
0.027799977,
0.0027404716,
0.0012878899,
0.011370323,
0.050382517,
0.026917228,
-0.009183215,
-0.0029216327,
0.01797117,
0.015191172,
0.0011470785,
-0.0477738,
-0.0014278779,
0.030303292,
-0.012641743,
0.007200326,
0.03164718,
0.010085726,
0.0054348297,
0.010494162,
0.0081489505,
-0.017417805,
-0.025573343,
-0.008208239,
0.02029003,
0.009031699,
0.00735843,
0.004038243,
-0.020276856,
-0.03288566,
-0.0104678115,
0.0073518422,
0.0027717631,
0.0084585715,
-0.022898749,
-0.008787955,
0.019657614,
0.029749928,
-0.016350603,
-0.0070026955,
0.0013743531,
0.0013356506,
0.0066008475,
0.0007522298,
-0.012885487,
0.012332123,
0.028274288,
-0.0071015107,
-0.013484965,
0.023900075,
0.0072464393,
-0.0024390856,
-0.010579801,
0.012813022,
0.003115969,
0.0046970104,
0.013254397,
0.0011404908,
-0.020421784,
-0.003094559,
-0.01530975,
-0.0012681269,
-0.005853147,
0.011067289,
0.003982248,
0.014295248,
-0.0067853024,
-0.005144972,
-0.024558842,
-0.007918382,
-0.014835438,
0.010322883,
0.020751167,
-0.0023270953,
-0.020540362,
-0.022846047,
-0.0035803998,
-0.0022694531,
-0.004858408,
0.0009206272,
-0.0018708989,
0.015428328,
0.021409934,
0.032042436,
-0.00401848,
0.011614067,
-0.01947316,
-0.02119913,
-0.01762861,
0.008504685,
-0.0065152077,
0.0019845362,
-0.017141122,
-0.010375584,
-0.0088604195,
0.0062385257,
0.055178344,
0.003636395,
-0.04089627,
-0.02578415,
-0.011989564,
-0.017272877,
0.0114889005,
0.008498097,
-0.007714164,
-0.0044137402,
-0.014822262,
0.007193738,
-0.003193374,
-0.011653592,
-0.019012023,
-0.012483639,
0.019012023,
0.030145189,
0.0072662025,
0.046219107,
-0.000843222,
0.003336656,
0.009907859,
-0.023241308,
0.021133253,
0.005602815,
0.02235856,
0.01791847,
-0.028142536,
0.020026524,
0.029196564,
0.0064888573,
0.026469268,
0.008471747,
0.021950124,
0.013491552,
-0.016416479,
0.011423023,
-0.019222828,
0.0055369386,
0.0018198445,
0.014506054,
-0.0032641916,
-0.0009873274,
0.024795998,
-0.012648331,
-0.00032608976,
-0.028537797,
0.021106903,
0.0019203065,
0.0047068917,
0.019156951,
-0.021304533,
-0.0210542,
0.01570501,
-0.0040678876,
0.002332036,
-0.009018524,
0.019736666,
0.031857982,
-0.0056588105,
0.0045487876,
-0.010085726,
-0.0024983748,
0.005569877,
0.017299227,
0.009216153,
0.006851179,
0.010270181,
0.03246405,
-0.002936455,
0.017602261,
-0.017483681,
-0.0029677462,
0.010342645,
0.0047332426,
0.017207,
0.02026368,
-0.0027371778,
0.019539036,
0.015573258,
-0.0037879115,
-0.012951364,
-0.0021821663,
0.007114686,
-0.023755146,
0.008919708,
0.0072464393,
-0.017496858,
0.0031176158,
0.02716756,
0.057602607,
0.0053426023,
0.02176567,
-0.0043116314,
0.015362452,
-0.002027356,
0.011870985,
0.02988168,
0.029249264,
-0.015217523,
0.021041024,
0.0095653,
-0.010573214,
-0.013939515,
-0.0010416757,
-0.011126579,
0.0004644309,
0.024795998,
-0.014189846,
0.008214828,
0.01782624,
0.009618001,
-0.0200924,
-0.023676094,
0.028221589,
0.048906878,
-0.006735895,
-0.020619415,
-0.011350559,
0.006531677,
-0.0040053045,
0.0034749971,
0.013168757,
0.01967079,
0.004298456,
0.009716816,
-0.0100462,
0.0010861425,
0.008662789,
0.002131112,
-0.009130513,
0.009038286,
0.036074094,
-0.015388803,
0.0031439667,
0.00053318974,
0.023188606,
0.0005574818,
-0.0075692353,
-0.01927553,
-0.023359885,
-0.036416654,
-0.005905848,
-0.007898619,
0.010876247,
-0.030487748,
0.011594303,
0.0009930916,
0.01799752,
0.0050527444,
0.012147668,
-0.010237243,
-0.0019598324,
-0.012872311,
-0.0077471025,
-0.01330051,
0.03133097,
0.015243874,
-0.0096641155,
0.013260984,
0.0057345685,
0.012852549,
0.00050601555,
-0.0080237845,
0.0022711,
-0.016166147,
0.002032297,
0.0041502337,
0.01321487,
0.008761604,
0.007760278,
0.016166147,
-0.013484965,
-0.03206879,
0.000101594254,
-0.0037022717,
0.019986998,
-0.025652396,
0.04353134,
0.02119913,
0.023504814,
-0.009525774,
0.020448135,
0.0116733555,
0.02943372,
0.00021348175,
-0.013175344,
0.0060771275,
0.003175258,
0.016429655,
0.0048518204,
-0.012009326,
0.0040349495,
0.0022414555,
-0.008366344,
-0.027220262,
0.01375506,
0.0123848235,
0.02164709,
-0.0035540492,
-0.012154255,
-0.013353212,
0.012312359,
0.0023534459,
0.018985672,
-0.03712812,
0.0030220947,
-0.004117295,
-0.028748602,
-0.015994867,
0.0017243233,
0.008794542,
-0.011324208,
-0.01740463,
-0.0018231383,
-0.004920991,
0.009295206,
-0.00707516,
0.016508706,
-0.01188416,
-0.012450701,
-0.00017179413,
0.0066107293,
-0.011218806,
-0.009031699,
-0.018708989,
-0.004281987,
-0.028537797,
-0.006195706,
0.018102923,
0.018853918,
0.0027832915,
-0.009967148,
-0.0036594518,
0.006653549,
0.04123883,
0.0018017284,
-0.005909142,
-0.0040744753,
-0.036864612,
0.0064987387,
0.007681226,
-0.017852591,
-0.019604912,
-0.008768192,
0.024374388,
-0.006617317,
-0.036153145,
0.021871071,
0.006607435,
0.0055105877,
0.008886769,
0.020395434,
0.006031014,
0.0038076746,
-0.0055007064,
-0.0013825877,
0.0046080765,
-0.011166104,
-0.017141122,
-0.02159439,
-0.01834008,
-0.012220132,
0.007384781,
-0.026759125,
-0.010171366,
0.019459983,
-0.026284812,
-0.0019219534,
-0.002812936,
-0.007892031,
0.0119829755,
0.0044367975,
0.024637895,
-0.0069631697,
-0.008629851,
-0.00086957274,
-0.010737906,
0.03855106,
-0.012582454,
-0.00698952,
0.00032629565,
-0.027931731,
-0.016087096,
-0.006254995,
-0.024163581,
-0.0064987387,
0.020026524,
0.0057378625,
-0.018155625,
-0.022450786,
-0.0066634305,
-0.019143775,
-0.00041975823,
0.009861745,
-0.019710315,
-0.036574755,
0.012404587,
0.005988194,
-0.033728883,
0.020843394,
-0.026521968,
-0.008155539,
0.023346711,
-0.015243874,
0.0003026212,
0.0125692785,
0.010098902,
-0.016732687,
-0.023333535,
-0.015810413,
-0.02716756,
-0.003517817,
-0.0127866715,
0.027747275,
0.06561322,
0.008254353,
-0.0007402897,
0.023280833,
0.02980263,
0.0007460539,
0.017470507,
-0.0063999235,
0.021726143,
-0.016350603,
0.02598178,
0.00642298,
-0.015560082,
0.024664246,
-0.0003633513,
0.022266332,
0.000904158,
0.007338667,
-0.00891312,
-0.012490227,
-0.035626132,
-0.03773419,
0.006231938,
-0.008129188,
0.021950124,
-0.030013435,
0.0044894987,
0.007061985,
-0.0019186595,
-0.0016551526,
-0.013247808,
-0.0033893574,
0.0071871504,
0.0016913848,
-0.0031274974,
-0.007845918,
-0.016126622,
-0.021106903,
-0.008682552,
-0.015428328,
-0.0081489505,
-0.006350516,
0.020052874,
0.0136233065,
-0.013445439,
0.0113637345,
0.00068182405,
-0.01491449,
-0.01873534,
-0.011416436,
-0.018116098,
-0.015072594,
0.0077536902,
-0.00928203,
-0.015836764,
-0.011442787,
0.016403304,
-0.01307653,
0.021607565,
-0.012108142,
-0.008247766,
0.021805195,
-0.014901315,
0.015810413,
-0.022016,
0.011712881,
0.009064637,
0.004545494,
-0.0043478636,
-0.012094966,
-0.0077273394,
0.008695727,
0.047510292,
0.008353168,
0.018682638,
0.008214828,
0.006291227,
0.004318219,
-0.019934297,
-0.016535057,
0.014967191,
-0.0049176975,
-0.0010482634,
-0.011785346,
-0.022872398,
-0.02403183,
-0.01233871,
-0.020052874,
0.022437612,
-0.006116654,
-0.024255808,
-0.038313903,
0.015388803,
-0.027720924,
0.008794542,
0.025257135,
-0.012674682,
-0.022253158,
-0.020474486,
0.0040085986,
-0.012279421,
-0.00486829,
0.017220175,
0.0015563376,
-0.005504,
0.03773419,
-0.022648416,
-0.012799847,
-0.008583737,
-0.014295248,
0.041871246,
-0.0043313946,
-0.011027764,
0.011231981,
-0.006729307,
0.011541602,
0.00327572,
-0.01397904,
0.00057395094,
-0.028485095,
-0.013445439,
0.018208327,
0.024993628,
-0.03475656,
-0.009598238,
-0.028537797,
0.00074193656,
-0.03565248,
-0.019091073,
0.01233871,
-0.042345557,
-0.012701032,
-0.018511359,
0.011976388,
0.0477211,
-0.0037846176,
0.0061924118,
-0.010184541,
0.043663092,
-0.01737828,
0.0039888355,
-0.0015513968,
0.010421697,
-0.035678834,
0.010599565,
-0.02504633,
-0.018353255,
-0.004120589,
-0.035072766,
-0.017154299,
-0.059921466,
-0.029908031,
-0.0042095226,
0.024716945,
-0.019183302,
0.01032947,
0.009934209,
0.022990976,
-0.02470377,
-0.018181976,
0.018287377,
-0.0048386455,
0.010889422,
0.007490183,
-0.011805109,
-0.036522053,
-0.043794844,
-0.010652266,
0.013142406,
0.0016279785,
0.0035869875,
0.00065670855,
0.027773626,
-0.006554734,
0.0043544513,
0.0003888785,
-0.0055369386,
-0.028643198,
0.025994955,
0.026627371,
0.0017803184,
-0.0022743938,
-0.0016732687,
-0.007997434,
0.024611544,
-0.02544159,
-0.010849896,
-0.02068529,
-0.028063484,
-0.026838176,
-0.008847244,
-0.016877616,
0.035757884,
0.016548233,
-0.01050075,
-0.018379606,
-0.016034395,
-0.014440178,
-0.0023962657,
-0.0031011468,
0.021383584,
-0.0154151535,
0.011311033,
-0.025230784,
0.010553451,
0.012516577,
0.009868333,
0.0032493693,
-0.018827567,
0.013676007,
-0.015441503,
0.028432393,
0.006910468,
-0.048406217,
-0.028168887,
0.048748776,
-0.032253243,
-0.016745863,
0.030461397,
-0.04123883,
0.022450786,
0.0073716054,
-0.0008926296,
-0.013768235,
0.026680073,
0.03172623,
-0.018985672,
-0.012088379,
0.00353758,
0.026087182,
0.007121274,
0.008807718,
-0.00006052424,
0.026271638,
0.0053590713,
-0.00687753,
-0.03280661,
-0.0014781089,
0.013676007,
-0.0017984345,
0.037628785,
0.010909185,
0.02102785,
-0.003837319,
-0.0030039786,
-0.0046970104,
-0.03141002,
-0.011330796,
0.019486334,
-0.0024851994,
-0.0044005653,
-0.025283486,
-0.0052931947,
0.014769562,
-0.007595586,
0.014110794,
0.0029660994,
-0.034730207,
-0.035020065,
0.018247852,
0.013148994,
-0.008708903,
-0.018010696,
-0.0071080984,
-0.022766996,
-0.012325535,
-0.018814392,
0.021805195,
-0.021831546,
-0.0048814653,
-0.015665485,
-0.0092293285,
0.0023830903,
-0.0058399714,
-0.029908031,
-0.016284727,
0.0088604195,
0.18677369,
-0.018827567,
-0.006205587,
0.010994825,
0.020342732,
0.008096249,
0.014321599,
-0.0123848235,
0.012174019,
0.008636438,
0.02982898,
-0.0067062504,
-0.02119913,
0.004202935,
-0.00124507,
-0.0037813238,
-0.04131788,
0.00040225973,
-0.005586346,
0.010303119,
-0.0051087397,
-0.0026630666,
0.0013340036,
-0.011001413,
0.042582713,
0.00056859845,
-0.012813022,
0.0031637296,
0.012332123,
-0.01661411,
-0.030645851,
-0.009927622,
0.01567866,
0.0050395695,
-0.021712968,
0.0046970104,
-0.0067260135,
-0.018155625,
-0.010909185,
-0.009585063,
0.007898619,
0.036021393,
-0.009835395,
0.012272834,
0.0030698553,
0.0105271,
0.011001413,
-0.00161645,
0.011350559,
-0.017233351,
-0.035810586,
0.011455962,
0.018089747,
0.031172864,
-0.00917004,
0.012121317,
0.01092236,
0.0029166918,
-0.008162126,
0.012727383,
-0.024242634,
0.00084486895,
-0.05056697,
0.027299313,
-0.0032823076,
0.0286959,
-0.036205847,
0.0040876507,
0.034414,
-0.012885487,
-0.010513925,
0.021146428,
-0.0047530057,
0.01395269,
0.00438739,
-0.018867094,
0.02374197,
0.009110751,
0.030066136,
0.018432306,
0.0009881508,
0.010494162,
0.00021759905,
-0.0058762035,
-0.009440134,
-0.03138367,
0.018919794,
0.011811696,
0.01984207,
0.010263593,
0.0056061093,
-0.0009338025,
-0.023478463,
-0.0008300467,
0.015375627,
0.020131927,
-0.019986998,
0.01782624,
-0.026021305,
-0.022569366,
-0.03098841,
0.06809018,
-0.0011421377,
0.013083117,
-0.0045586694,
-0.0031801988,
-0.006870942,
0.021251831,
0.015915817,
-0.005671986,
0.018788042,
-0.013083117,
0.008247766,
-0.030724904,
-0.005490825,
0.024967277,
-0.0035507553,
-0.007068572,
-0.0051153274,
-0.019683965,
0.0054348297,
-0.027352015,
-0.014809087,
0.028643198,
-0.00072382047,
0.0131885195,
0.0011923687,
-0.008076486,
0.024150407,
-0.02204235,
-0.0031456135,
-0.005286607,
-0.011416436,
0.004581726,
0.020777518,
-0.0077075767,
0.025138557,
-0.0030797368,
-0.015428328,
0.021357233,
0.0011726057,
0.01013184,
-0.0071278615,
0.015994867,
0.004805707,
-0.04700963,
0.012938188,
0.009519187,
-0.0046904227,
0.001205544,
-0.017259702,
-0.020105576,
-0.02430851,
-0.007654875,
0.022977801,
-0.03220054,
-0.030435046,
-0.009077813,
-0.0069038807,
0.023175431,
-0.016798563,
-0.0129711265,
0.023188606,
-0.017707663,
-0.0057806824,
0.021976475,
-0.16495532,
0.022648416,
0.031937037,
-0.018972496,
0.02603448,
0.010125252,
0.009525774,
-0.0061133597,
-0.009967148,
0.018959321,
0.026271638,
-0.009189803,
-0.019907946,
-0.016152972,
0.0026663602,
-0.0130962925,
0.013570605,
0.042371906,
0.030145189,
-0.0022266333,
0.017022545,
-0.011034351,
0.01530975,
-0.0077734534,
-0.01890662,
0.010770844,
-0.0064888573,
-0.0067161317,
0.0012014267,
-0.007536297,
-0.00046772472,
0.0035507553,
0.013702358,
-0.014506054,
0.019789368,
0.003010566,
-0.0041041197,
-0.006271464,
-0.015138471,
0.007463833,
0.0019252473,
0.014532405,
0.0038142623,
0.010395347,
-0.021897422,
0.006709544,
0.0085507985,
0.005813621,
0.006495445,
0.0139922155,
0.0138999885,
0.01565231,
0.013689183,
0.008083073,
0.014216197,
-0.014137144,
0.0075297095,
0.010902598,
-0.00390649,
-0.006650255,
-0.026390215,
-0.029697226,
0.03167353,
0.010085726,
-0.014031742,
-0.013181932,
-0.027062157,
0.00059659604,
-0.051014934,
0.004502674,
-0.032727554,
-0.0017523208,
0.01567866,
-0.026508793,
0.023597041,
0.01718065,
-0.0004327277,
0.0055336445,
0.020105576,
-0.00033391264,
0.008616676,
-0.007094923,
-0.027009455,
-0.005592934,
-0.012740558,
0.00046113707,
0.004848527,
0.020935623,
-0.011614067,
0.00002660802,
0.014466528,
-0.026825001,
-0.0027256494,
-0.011475725,
-0.004545494,
0.0074835955,
0.007332079,
-0.017062072,
-0.009387433,
-0.012944776,
0.01974984,
-0.010830133,
-0.02507268,
-0.00035244046,
0.04097532,
-0.00482547,
-0.014440178,
-0.008893358,
0.04503333,
-0.0028722251,
-0.011054114,
-0.0095653,
-0.0043577454,
0.021106903,
0.008787955,
0.017259702,
0.025204433,
-0.0006110066,
0.014466528,
-0.028274288,
0.06350516,
0.015098945,
0.032727554,
0.018919794,
0.015046244,
-0.007793216,
-0.12901297,
-0.03141002,
0.012160843,
0.012160843,
-0.024927752,
0.02026368,
-0.013063354,
0.013873638,
-0.041107073,
0.03984224,
0.008899945,
-0.0125692785,
-0.0033448907,
0.002070176,
0.025309836,
-0.009400608,
0.0073716054,
0.0049407543,
-0.0073254914,
0.030382344,
-0.01508577,
-0.00056283426,
-0.00073617237,
0.002714121,
0.03491466,
-0.001435289,
-0.013741884,
0.010448048,
0.008155539,
0.0061989995,
-0.017444156,
-0.016284727,
0.009018524,
-0.0015497499,
-0.012806435,
-0.0013274159,
-0.009973736,
-0.02470377,
0.029565472,
-0.014005391,
0.0016946787,
0.0127866715,
0.015915817,
0.0155073805,
-0.020000173,
-0.028854005,
-0.028880356,
0.0066798995,
0.026732774,
0.00059865473,
-0.027720924,
-0.031041112,
-0.024045004,
-0.00727279,
0.009611414,
-0.015533731,
0.020171452,
0.030013435,
-0.02366292,
0.0016131563,
-0.00984857,
0.0068050656,
-0.02085657,
0.034308597,
0.024492966,
0.0073979557,
-0.01587629,
-0.0064888573,
0.01548103,
-0.015362452,
-0.0014822263,
-0.014295248,
-0.021686617,
-0.0028014076,
-0.029618174,
0.014413827,
-0.009585063,
-0.0007658169,
0.0515683,
-0.035678834,
-0.005523763,
-0.009426959,
0.016824914,
-0.0062846392,
0.024716945,
0.015981693,
0.0028623436,
0.0009988558,
-0.002694358,
-0.014571931,
-0.004588314,
0.03934158,
-0.029328316,
-0.018247852,
-0.012444112,
-0.0065020323,
-0.005741156,
-0.002071823,
0.017220175,
0.01698302,
-0.016600935,
-0.015836764,
-0.050619673,
0.012332123,
-0.013155581,
-0.0155073805,
0.023214957,
0.0058333836,
0.009657527,
0.0048946403,
0.012529752,
0.009387433,
-0.011851222,
0.02142311,
-0.013570605,
-0.0044335034,
-0.01873534,
-0.0031867865,
0.00928203,
-0.013715534,
-0.0009634471,
0.044611715,
-0.009499423,
-0.03172623,
0.019736666,
-0.012081791,
-0.030777605,
-0.028406043,
0.007061985,
0.03175258,
-0.027009455,
-0.01703572,
0.008050135,
-0.03475656,
-0.003959191,
-0.005569877,
-0.029328316,
0.000884395,
-0.016719513,
0.026614197,
0.01938093,
0.029275615,
-0.017536383,
-0.057918813,
0.00059042015,
-0.009914447,
-0.027483769,
-0.021146428,
-0.04888053,
0.0136233065,
0.0008687493,
0.018234678,
0.015033068,
-0.0051976736,
0.011666767,
-0.030856656,
-0.029697226,
-0.004703598,
-0.019091073,
-0.028748602,
-0.045876548,
-0.011627242,
0.008959235,
0.05125209,
-0.003036917,
0.002111349,
-0.0017852592,
-0.017615436,
-0.031594478,
-0.0017440863,
0.0033448907,
-0.02139676,
-0.0013628247,
-0.0089526465,
-0.00073452544,
0.006745776,
0.010652266,
-0.01069838,
-0.023280833,
0.019947471,
-0.0027552939,
0.020896096,
-0.00031867865,
0.016745863,
-0.02598178,
0.0015810414,
0.015362452,
0.010625916,
-0.019960647,
0.000993915,
0.024255808,
0.001024383,
0.024756473,
0.03146272,
0.021014674,
0.009479661,
0.01700937,
0.018234678,
-0.015441503,
0.008781367,
0.0041568214,
0.035046417,
-0.009268855,
0.0020421783,
-0.002893635,
-0.0144270025,
-0.011627242,
0.0133729745,
-0.020922447,
-0.020566713,
-0.018221501,
0.016008044,
-0.008946059,
0.002814583,
0.010204304,
-0.010744493,
-0.019236002,
0.0030122132,
-0.0021047613,
-0.00077199284,
-0.023781497,
0.032595802,
0.0086430255,
0.001557161,
0.0017095009,
0.012813022,
0.008702315,
0.013392738,
0.032095138,
-0.031120164,
0.0030204477,
-0.005727981,
-0.00031064992,
-0.018010696,
-0.040738165,
-0.014743211,
-0.010823545,
-0.0068643545,
-0.0062978147,
-0.000974152,
-0.020751167,
0.07304411,
0.027852679,
-0.011126579,
-0.0014476409,
-0.012318947,
0.038445655,
0.0026416567,
-0.00044384442,
-0.016785389,
-0.02679865,
0.002812936,
-0.020843394,
-0.00094944827,
-0.025178084,
-0.009697054,
0.024150407,
0.007220089,
-0.008379519,
-0.0023765028,
-0.012720795,
0.004657484,
-0.01698302,
0.017720839,
0.009618001,
-0.045454938,
-0.0013397678,
0.024427088,
0.028142536,
0.006248407,
-0.011758995,
-0.016021218,
-0.030013435,
-0.03098841,
-0.016456006,
0.022121403,
-0.014637807,
-0.017114773,
-0.034572102,
0.016851265,
0.027114859,
0.0129316,
0.012470463,
-0.025151733,
-0.050698727,
-0.0085507985,
-0.0046014893,
-0.00026433036,
-0.02541524,
-0.008142363
] |
Bipolar disorder is a severe psychiatric disorder that is associated with persistent changes in the quality, duration and architecture of sleep. Currently there is no unifying hypothesis explaining the alterations in sleep observable in patients with bipolar disorder and management is often difficult though vital. Sleep is modified by various cytokines including IL-6. Elevated levels of IL-6 are associated with a poorer quality of sleep and changes in the architecture of sleep similar to those observed in bipolar disorder. Therapeutic administration of Interferon causes elevations of intrathecal IL-6 concentrations and appears to provoke a deteriorating quality of sleep. The blockade of IL-6 with | [
-0.0048977793,
0.026147507,
0.0258353,
-0.035175554,
-0.035565816,
0.015415322,
-0.026394673,
-0.011733857,
-0.006634442,
-0.0023074201,
-0.014270555,
0.010367942,
0.010732186,
0.002726951,
-0.014855947,
-0.0010089881,
0.03189736,
-0.00008572537,
0.0054994323,
0.0064360597,
-0.01442666,
0.014842939,
0.014738869,
0.006097833,
-0.013698172,
-0.0012488362,
0.00967848,
-0.033120178,
-0.0155324,
-0.0139843635,
0.0008028814,
-0.017171498,
-0.020449692,
0.008078409,
0.012924154,
-0.01593567,
0.013906311,
-0.0037139868,
0.008520706,
-0.023142496,
0.03840171,
-0.007928809,
-0.009502863,
0.016273897,
0.008696323,
0.008058896,
-0.0015789323,
-0.029113494,
0.008657297,
0.009984185,
0.029815964,
0.013067249,
-0.013314415,
-0.030518435,
0.004611588,
-0.008670306,
0.011805405,
-0.029529773,
0.011558239,
-0.023155505,
0.006634442,
-0.010218342,
-0.025419021,
0.0020911503,
0.008488184,
0.0075840782,
-0.024261246,
0.026186533,
-0.006260442,
0.0046961443,
0.06457524,
0.038349677,
-0.03340637,
-0.005967746,
-0.0021252981,
0.0005016484,
-0.0060718157,
-0.01200704,
0.0041432744,
0.0020813937,
0.031507097,
-0.0051774667,
-0.031090818,
0.0057921284,
0.004247344,
0.0009480098,
-0.018446352,
0.0061596246,
-0.023897002,
0.020501727,
-0.00029167967,
0.0112330215,
0.017340612,
0.032053463,
0.0023496982,
0.02945172,
-0.009008532,
0.017873969,
-0.0017935759,
0.00027765468,
0.00215782,
0.008923976,
-0.02804678,
-0.0069141295,
-0.021321276,
-0.011070413,
-0.014478695,
0.012930659,
0.017236542,
-0.0066929813,
-0.016716193,
0.024157176,
0.019890318,
-0.05036973,
0.032157533,
0.011486691,
0.0061271028,
0.0076426174,
0.0009845968,
-0.025757248,
0.021048093,
0.02158145,
0.014452677,
0.0051351883,
0.0053921104,
0.0042408397,
-0.024443367,
-0.016781237,
-0.0033253515,
-0.011122447,
-0.019604126,
0.006745016,
0.00009797185,
-0.01654708,
-0.028150849,
-0.00045164616,
0.0025513333,
-0.037647206,
-0.020618806,
-0.023194531,
-0.0070051905,
0.007467,
-0.019630143,
-0.0049172924,
0.012611945,
0.04287671,
0.0069921818,
0.006797051,
-0.010641125,
-0.006686477,
-0.0023236808,
-0.0027692292,
0.003951396,
0.0030115165,
-0.010628116,
0.034160875,
-0.027994744,
0.046753306,
-0.029087476,
-0.009808567,
-0.0054148757,
-0.023545766,
0.018459361,
0.047846038,
0.011128952,
0.0027545944,
-0.0060815723,
-0.014036398,
0.00070206384,
-0.0010016707,
0.019083777,
0.011668813,
-0.041185576,
0.038349677,
-0.0123452665,
0.020657832,
-0.011298065,
0.0009845968,
-0.015675496,
-0.023949036,
-0.015753549,
0.011616779,
0.03036233,
-0.0032180299,
-0.03207948,
-0.0032164038,
0.030414365,
-0.024651507,
0.011727353,
0.008657297,
-0.01603974,
0.004998597,
-0.017002385,
-0.039858688,
-0.63649017,
-0.029087476,
-0.0032310386,
0.009151628,
-0.0022212374,
0.026342638,
0.008384114,
0.011831422,
0.006484842,
0.008657297,
0.004029448,
0.009288219,
0.010094759,
-0.041003454,
-0.0074409824,
-0.01594868,
0.0014838061,
-0.02370187,
0.0018000803,
-0.0044229617,
-0.009971176,
0.00068377034,
-0.022414008,
0.009125611,
0.005636024,
0.015285235,
0.030934714,
-0.017704856,
-0.012982693,
0.042538483,
-0.00852721,
0.030830644,
0.0148949735,
0.0149860345,
0.05385606,
-0.02724024,
-0.0052815364,
0.015987705,
0.050473798,
0.019395987,
-0.016521063,
-0.030102156,
0.016169827,
0.018563429,
-0.0116883265,
0.017548751,
-0.0061433637,
-0.01200704,
0.023571784,
0.0027220726,
0.004728666,
-0.004894527,
-0.011291561,
0.012098101,
0.022609139,
0.0051774667,
-0.0009829707,
-0.024742568,
0.008045888,
-0.0063059726,
0.0010293142,
0.010016707,
-0.018836612,
-0.013067249,
-0.004979084,
0.0066572074,
-0.0050864057,
-0.03207948,
0.026563786,
0.0014504712,
-0.00080979225,
0.041107524,
-0.017093446,
0.016299915,
0.02198472,
0.010380951,
0.008949993,
0.026160516,
-0.008364601,
-0.014114451,
-0.012885128,
-0.012878624,
-0.03348442,
-0.03481131,
0.04295476,
0.0069856774,
-0.0041823005,
0.033562474,
-0.028150849,
0.008462166,
0.01875856,
-0.0056327716,
0.011363109,
-0.021308267,
-0.02752643,
0.033458404,
0.0044945097,
-0.0076816436,
0.0183683,
0.0047872053,
0.015207183,
0.008605262,
-0.01817317,
0.014179494,
0.043735284,
0.0090475585,
-0.0036164215,
-0.017314594,
0.045140225,
-0.020605797,
0.016989376,
-0.012039562,
-0.005070145,
-0.010927317,
0.011701335,
-0.019018734,
0.011681822,
0.0035221083,
-0.0030472905,
-0.0074214693,
0.00024574267,
-0.0054506497,
0.013346937,
-0.0007809292,
-0.0030895688,
0.017067429,
0.018992716,
-0.02017651,
-0.025939368,
-0.005733589,
-0.011193995,
0.0052262493,
0.033172213,
-0.00982808,
-0.0060457983,
0.0015220192,
0.036294304,
-0.01905776,
0.017886978,
-0.03624227,
-0.012176153,
-0.00089109666,
0.0017821933,
0.025236899,
-0.0026960552,
-0.017548751,
-0.018095117,
-0.013750207,
0.005915711,
0.013464015,
-0.0039839176,
-0.027656518,
-0.02087898,
0.036190234,
0.022023747,
-0.014517721,
0.002819638,
-0.002510681,
-0.026797943,
0.0014683582,
0.010758203,
0.017392647,
-0.003918874,
0.015896644,
-0.0023578287,
-0.031559132,
0.016000714,
0.016091775,
-0.01584461,
-0.019799257,
-0.00016870671,
-0.013119284,
-0.014244538,
-0.018576438,
-0.0046018315,
-0.00044717442,
0.013672154,
-0.012078588,
-0.0001836464,
-0.0051742145,
0.0040749786,
0.018485378,
-0.019903326,
-0.017236542,
0.014127459,
0.011057404,
0.044255633,
0.006666964,
-0.0059937635,
0.01715849,
-0.010426481,
0.050083537,
0.006042546,
-0.00068417686,
0.002835899,
0.008813402,
0.013880294,
-0.013223354,
0.016482037,
0.009112602,
0.014517721,
-0.021542424,
-0.007161295,
-0.016560089,
0.034941398,
-0.035773955,
0.0024797854,
-0.020970041,
0.02511982,
-0.0013163189,
-0.018641481,
0.009359767,
-0.00034513735,
-0.0028098815,
-0.0055384585,
0.01847237,
-0.021867642,
0.017392647,
0.0005508376,
-0.020150492,
-0.0055774846,
0.0149860345,
0.002837525,
0.015571427,
0.020918006,
0.0044001965,
0.03473326,
0.001868376,
0.03452512,
0.00062360504,
-0.007909296,
0.020189518,
0.008949993,
0.0028537859,
-0.011252535,
0.0150770955,
0.010296394,
-0.013906311,
0.039780635,
0.011844431,
0.008644288,
0.014114451,
-0.0027919945,
-0.015753549,
-0.0038017957,
-0.007636113,
0.0109598385,
0.016534071,
-0.0012992449,
-0.0031009514,
-0.024105141,
-0.018784577,
-0.008923976,
-0.01033542,
-0.0058864416,
-0.0049172924,
-0.0031058297,
0.016221862,
0.047273654,
0.007961331,
0.0018082107,
-0.004406701,
-0.0012081839,
0.0066246856,
-0.002234246,
0.0008000357,
-0.0032554297,
-0.010504534,
0.00033050255,
0.0068555903,
-0.038167555,
0.0070051905,
0.028072797,
-0.037282962,
0.04459386,
-0.015818592,
-0.0035838997,
0.012885128,
0.019851292,
0.016130801,
-0.0044587357,
-0.022674182,
0.0075515565,
0.007863766,
0.008858932,
0.0095744105,
-0.008182479,
0.008449158,
0.0045985794,
0.023441697,
-0.007824739,
-0.004728666,
0.012150136,
-0.027344309,
0.014036398,
0.008540219,
0.01996837,
-0.0005398615,
0.015415322,
0.004429466,
0.008110931,
0.00018608554,
-0.0054799193,
0.011493196,
0.0048685097,
0.00952888,
-0.017483708,
-0.00046628097,
-0.01895369,
-0.009262201,
0.0064132945,
-0.008215001,
-0.019825274,
-0.004504266,
0.0019155326,
0.002653777,
-0.0023139243,
0.0036847172,
0.001722028,
-0.011798901,
-0.008533714,
-0.034056805,
-0.0361382,
-0.01381525,
0.03730898,
0.015246209,
0.0031627428,
0.026980065,
0.013490032,
-0.004114005,
-0.019382978,
-0.031507097,
0.024807611,
0.00038111457,
0.0023952287,
-0.021607468,
-0.0003689189,
0.008097922,
-0.01865449,
0.01362012,
0.0142575465,
-0.017939012,
0.0072783735,
0.016273897,
-0.003879848,
-0.012078588,
0.009737019,
0.038661886,
0.029477738,
-0.014335599,
0.0016878801,
0.024105141,
-0.015727531,
-0.0425645,
-0.034785293,
-0.004712405,
0.0035318648,
0.03941639,
-0.016325932,
0.007850757,
0.013685163,
0.00068051816,
0.0056100064,
-0.011018378,
0.0076621305,
0.006273451,
0.008351592,
0.013711181,
0.0003270471,
0.0003589591,
-0.014842939,
0.0032749427,
-0.0008862184,
0.02874925,
0.029087476,
-0.0076426174,
-0.0027432118,
-0.0043481616,
0.0027871162,
-0.0053173103,
0.011623283,
-0.013132293,
-0.009372775,
0.0016602366,
-0.0025724724,
-0.023038426,
0.012689997,
-0.0047384226,
-0.019539082,
-0.019031743,
0.007863766,
-0.013151806,
-0.020202527,
-0.008260531,
0.013685163,
-0.030492418,
-0.01875856,
-0.0011976144,
0.032443725,
0.010699664,
0.016495045,
-0.009099593,
0.023454705,
0.0118704485,
-0.03179329,
-0.011402135,
0.024430359,
0.004078231,
0.01276805,
0.008234514,
0.022648165,
-0.024742568,
-0.0050148577,
-0.0019204109,
0.0066572074,
-0.010257368,
0.0040522134,
0.0040164394,
-0.00016372681,
0.024066115,
0.031142853,
0.031507097,
-0.011701335,
-0.032105498,
0.012865615,
-0.008384114,
-0.02017651,
-0.0028781772,
0.0030294035,
-0.023272583,
0.011259039,
0.00079881615,
-0.02188065,
-0.0094833495,
0.015220191,
-0.028202884,
-0.017041411,
0.018407326,
0.009737019,
0.0061628767,
-0.0385318,
0.017483708,
0.019734213,
-0.016924333,
-0.021412337,
-0.0270321,
0.014309581,
0.011356604,
-0.013789233,
-0.0013772972,
0.005762859,
0.0013992494,
-0.008761367,
-0.017548751,
-0.027708553,
0.036164217,
-0.00019065892,
-0.030804627,
-0.031637184,
0.0033594994,
-0.006146616,
0.019526074,
-0.00029716772,
-0.0067124944,
0.000062553605,
-0.00011250502,
-0.0022033504,
-0.013385963,
0.04214822,
-0.032053463,
-0.010452499,
0.004979084,
0.00038233414,
0.0038570827,
-0.0065726507,
-0.013288397,
-0.028671198,
-0.013724189,
0.014842939,
-0.027292274,
0.0029529773,
-0.0039416393,
0.058383092,
0.031507097,
0.018667499,
0.021620477,
-0.00816947,
0.0077727046,
0.0017529237,
-0.0015797453,
-0.015480366,
0.0039123697,
-0.028020762,
0.017886978,
0.013542067,
0.0009780924,
0.008735349,
-0.033666544,
0.029737912,
0.016677167,
-0.024157176,
-0.018641481,
-0.010146794,
-0.0041302657,
-0.017886978,
0.0022911592,
-0.003315595,
-0.0045302836,
-0.0125273885,
-0.011584257,
0.0062474334,
-0.0015390931,
0.012533893,
-0.021217206,
0.017574769,
-0.034342997,
0.0344991,
-0.0051026666,
-0.0028261424,
-0.0076100957,
-0.0067515206,
0.0005971811,
0.011532222,
0.026056446,
-0.011493196,
0.031559132,
-0.003570891,
0.004374179,
0.008462166,
0.013945337,
-0.028072797,
0.0076166,
-0.01236478,
-0.012755041,
0.00005106935,
-0.013477024,
-0.012403806,
-0.04225229,
0.0057986327,
0.015662488,
-0.009073576,
0.018797586,
-0.010478516,
-0.012689997,
0.015142139,
-0.013672154,
-0.0025334463,
-0.022960374,
0.032053463,
-0.0047709444,
-0.014973026,
-0.00812394,
-0.0139843635,
0.006614929,
0.0032294125,
0.0258353,
0.018433344,
-0.012533893,
-0.004767692,
0.008280044,
0.020215536,
-0.006559642,
-0.024755577,
0.0057043196,
-0.0016114541,
0.01563647,
0.0070377123,
-0.026745908,
-0.021672511,
0.021152163,
-0.012807076,
0.037751276,
-0.016482037,
-0.0078117307,
-0.011974518,
0.011772883,
-0.033874683,
0.00988662,
-0.0013081884,
-0.002691177,
0.0002278557,
0.0048847706,
-0.02843704,
0.00037074825,
-0.0044164574,
0.03278195,
-0.014153477,
0.008436149,
0.0074019562,
0.023129487,
0.021152163,
-0.003058673,
-0.031923376,
0.039988775,
-0.010550064,
0.009587419,
0.0070572253,
-0.013184328,
0.0087548625,
0.0030261513,
-0.013789233,
-0.0057531022,
-0.020931015,
0.023376653,
0.015025061,
0.012150136,
0.00274809,
0.004084735,
-0.03840171,
-0.022231886,
-0.014478695,
0.0015854366,
-0.009314236,
-0.048808683,
0.009470341,
-0.019487048,
-0.00040022112,
0.015818592,
0.017704856,
-0.0102118375,
-0.012592432,
0.017574769,
-0.03036233,
0.008832915,
-0.003239169,
0.018511394,
-0.0074084606,
-0.006686477,
-0.009242689,
-0.022283921,
-0.0035773953,
-0.0030635514,
-0.030336313,
-0.014491703,
0.008624775,
0.022075782,
-0.011915979,
0.012755041,
0.025991403,
0.003974161,
0.0004540853,
0.0035481257,
-0.037673224,
0.011551735,
-0.038089503,
0.0059970156,
0.015090104,
0.009262201,
-0.002509055,
0.002819638,
0.030596487,
0.011363109,
-0.010068742,
-0.015909653,
-0.009834585,
-0.00903455,
-0.011811909,
0.00054595934,
-0.004322144,
-0.019643152,
-0.0310648,
0.02026757,
0.014647808,
0.015402313,
-0.031637184,
-0.004504266,
0.011811909,
0.019981379,
0.0040034307,
-0.010257368,
-0.0014138842,
-0.026693873,
-0.024560446,
-0.006042546,
0.00017673553,
0.023363644,
0.008657297,
-0.014881965,
-0.011675318,
-0.023975054,
-0.03116887,
0.0061628767,
0.023988063,
0.008943489,
0.009171141,
0.007050721,
-0.008709332,
0.016976368,
0.008136949,
0.0027984988,
-0.024586463,
-0.015883636,
0.016495045,
0.0021074112,
0.030284278,
-0.00509291,
-0.02056677,
0.007649122,
0.017470699,
-0.009912637,
-0.0037400043,
0.02682396,
-0.016690176,
-0.011935492,
0.00234482,
0.026186533,
-0.026771925,
0.008338584,
-0.013281893,
-0.014699843,
-0.0013423363,
0.00012419253,
0.0082084965,
-0.027084135,
0.01796503,
0.012221684,
-0.005515693,
-0.010602099,
-0.03645041,
-0.026134498,
0.0050441273,
-0.03462919,
0.016430002,
0.03197541,
0.010933821,
0.007453991,
-0.018615464,
-0.011272048,
-0.012670484,
0.01170784,
0.0053205625,
0.006312477,
0.018823603,
-0.008201992,
-0.011675318,
0.02682396,
-0.00016687736,
0.002509055,
0.012319249,
-0.038349677,
0.01185744,
-0.04105549,
-0.0045985794,
0.010888291,
-0.006725503,
-0.0036944738,
-0.022075782,
-0.004296127,
-0.002030985,
-0.0057368414,
0.003372508,
-0.014413651,
0.014569756,
0.005366093,
0.007876774,
-0.0046050837,
-0.014036398,
-0.015818592,
-0.019513065,
0.019539082,
0.18753357,
-0.012755041,
-0.0059352242,
0.013568085,
-0.003369256,
0.010283385,
0.013106275,
0.0010236229,
-0.010361438,
0.026797943,
0.028489076,
-0.023155505,
0.007837748,
0.00340503,
0.016286906,
-0.02250507,
-0.045036156,
0.0048977793,
-0.0084816795,
-0.013867285,
-0.010628116,
-0.008351592,
0.0022066026,
-0.0037139868,
0.02178959,
0.011850935,
-0.015480366,
0.004266857,
0.017314594,
0.020605797,
-0.024690533,
0.007564565,
-0.006062059,
-0.013945337,
0.0018878891,
0.0061368593,
-0.0043969443,
-0.026745908,
-0.030154191,
-0.008306062,
-0.017236542,
-0.009145124,
-0.02128225,
-0.01003622,
0.0144396685,
0.009359767,
-0.005544963,
-0.0022000982,
0.027214222,
0.010062237,
-0.039494444,
-0.02149039,
0.032365672,
0.041575838,
0.014777895,
-0.012624954,
0.020488719,
0.029321633,
-0.011792396,
0.017522734,
0.0063222335,
0.018875638,
-0.03663253,
0.035279624,
0.01124603,
0.034264944,
-0.017795917,
0.019044751,
0.0030098904,
-0.007668635,
0.016195845,
-0.020891989,
-0.039078165,
0.0031692472,
0.0021545677,
-0.00827354,
0.045764644,
0.030882679,
0.004780701,
0.02340267,
-0.020358631,
0.014881965,
-0.012689997,
0.0092296805,
-0.0071482863,
-0.028905354,
0.02472956,
0.0013862407,
-0.043032814,
-0.015454348,
0.0100297155,
-0.017912995,
-0.0010764708,
0.0037855348,
0.028983407,
-0.033666544,
-0.0073499214,
-0.012098101,
-0.014517721,
-0.020931015,
-0.016638141,
0.076491214,
0.027968727,
0.0013886798,
-0.038193572,
-0.028385006,
-0.009021541,
-0.014088433,
0.013867285,
-0.0059807547,
0.025197873,
-0.034290962,
0.012137127,
-0.027266257,
-0.0052490146,
0.018381309,
0.014244538,
-0.03850578,
0.009724011,
-0.0021139155,
0.012605441,
-0.0024521418,
0.020059431,
0.003444056,
-0.0019838284,
0.006758025,
0.0021659504,
-0.0040196916,
0.0066441987,
-0.032131515,
0.0029204555,
-0.017912995,
0.0009138619,
-0.02895739,
0.0035221083,
0.011850935,
0.014973026,
-0.011187491,
0.014816921,
0.008091418,
0.0009919142,
-0.009158133,
0.0012293231,
-0.009177646,
0.016638141,
-0.018524403,
0.018446352,
0.0007012508,
-0.017340612,
0.0036359346,
-0.013958346,
-0.027448379,
0.021555433,
-0.015818592,
0.012852606,
-0.019330943,
-0.0047579356,
-0.034238927,
-0.014296573,
0.016911324,
-0.023727888,
0.014127459,
0.025991403,
-0.010836256,
-0.0013163189,
0.00431564,
-0.16214056,
0.017912995,
0.015480366,
-0.018043082,
0.008722341,
0.0011114317,
-0.0047709444,
-0.020111466,
-0.020462701,
-0.012683493,
0.011759874,
0.014374625,
-0.026875995,
-0.0061075897,
0.010127281,
-0.015584435,
-0.020865971,
0.03551378,
0.014452677,
0.015363287,
0.00027196336,
-0.04014488,
-0.00031952644,
-0.0310648,
0.0004918919,
0.0065856595,
0.010771212,
0.022622148,
-0.0010382577,
-0.030908696,
-0.016065758,
-0.010933821,
0.037543137,
0.017093446,
0.016729202,
0.0036359346,
-0.0090475585,
-0.022882322,
0.0039644046,
0.013086762,
0.032235585,
0.01895369,
0.020852963,
0.029087476,
-0.010055733,
0.02350674,
0.008579245,
0.015896644,
0.002159446,
-0.007284878,
0.0076035913,
-0.009815072,
-0.0066799726,
0.006221416,
-0.00081995525,
-0.0055059367,
0.022726217,
0.013958346,
-0.013568085,
0.011369613,
-0.03533166,
-0.032105498,
0.035904042,
0.0019139065,
0.017067429,
-0.024131158,
0.005967746,
0.019630143,
-0.0005878311,
0.0055026845,
-0.020046422,
0.013249371,
0.0047904574,
-0.0022358722,
0.013685163,
0.0003087536,
-0.015142139,
0.013288397,
-0.003899361,
-0.0106866555,
-0.024547437,
0.013945337,
-0.025861317,
-0.02259613,
-0.014270555,
-0.0049237967,
0.008058896,
0.029087476,
-0.0061075897,
-0.0068816077,
0.014309581,
-0.02976393,
0.023038426,
0.002930212,
0.008136949,
0.013529059,
0.012442832,
0.003606665,
-0.0043058833,
0.006579155,
0.01574054,
0.003092821,
-0.0005089658,
0.00787027,
0.008254027,
-0.01705442,
-0.020436684,
-0.00721333,
0.020839954,
-0.021295259,
-0.011382622,
-0.0023610808,
-0.0040131873,
0.026290603,
-0.008670306,
-0.003954648,
0.0114151435,
0.007271869,
0.015142139,
-0.013841268,
0.07685546,
0.0011992404,
-0.011382622,
0.0031172123,
-0.022036755,
-0.030492418,
-0.12602839,
-0.026394673,
0.0015472235,
-0.0033660037,
0.0018960196,
0.010998865,
0.012729024,
0.012774554,
-0.008741854,
0.016534071,
-0.02341568,
-0.012137127,
-0.0009642707,
-0.0056457804,
0.008722341,
0.034134857,
0.0051547014,
-0.002178959,
0.0008313379,
0.038479764,
0.0038896045,
-0.020787919,
0.0008358096,
0.0041237613,
0.004100996,
-0.017015394,
-0.021815607,
0.004279866,
0.016690176,
0.039390374,
0.005531954,
-0.004175796,
0.00993215,
0.020918006,
-0.010517542,
-0.0021545677,
-0.008338584,
-0.018784577,
0.02874925,
-0.01805609,
0.008793889,
0.008624775,
0.0148949735,
-0.011063908,
0.021165172,
0.006484842,
-0.01865449,
0.006058807,
0.04074328,
-0.008475175,
-0.015870627,
-0.019591117,
-0.026277594,
-0.026446708,
0.020397658,
0.0056262673,
0.01185744,
0.045660574,
-0.022322947,
0.016260888,
0.010732186,
0.011337091,
-0.023949036,
0.014036398,
0.01865449,
-0.023012409,
-0.005840911,
-0.026954047,
0.031507097,
-0.006598668,
-0.02794271,
0.0078117307,
-0.020189518,
-0.01695035,
-0.024664516,
0.0025545855,
-0.0070442166,
-0.025067786,
-0.009262201,
0.013750207,
-0.021620477,
0.00053335715,
0.03382265,
0.005021362,
0.01028989,
0.0155324,
0.012202171,
-0.025366986,
-0.011467178,
0.027214222,
0.010426481,
0.026134498,
-0.0013854277,
-0.02502876,
0.0064718337,
-0.0050799013,
-0.0021350547,
-0.00908008,
0.0069141295,
0.01594868,
-0.0071743038,
-0.0072978865,
-0.043605197,
0.019395987,
-0.006888112,
0.015428331,
0.019552091,
-0.020293588,
0.0075905826,
-0.011772883,
0.008397123,
0.0011943622,
0.012280223,
-0.005144945,
-0.0077011567,
0.009906133,
-0.03371858,
-0.0072198343,
0.030232243,
0.0026049942,
0.018303256,
0.008566236,
-0.021607468,
0.0076816436,
-0.010172811,
0.021412337,
-0.01976023,
-0.028671198,
0.007655626,
0.025041768,
-0.02631662,
-0.019148821,
0.02028058,
-0.010537055,
-0.029920034,
0.018212195,
-0.026186533,
-0.050317694,
-0.004065222,
0.033120178,
0.016781237,
0.05323164,
-0.017821934,
-0.039962757,
0.0061986507,
-0.013268884,
0.0055189454,
-0.000101325655,
-0.03593006,
0.01362012,
-0.005330319,
-0.02621255,
0.01624788,
0.018017065,
-0.004712405,
-0.025796274,
-0.01684628,
0.006185642,
-0.00801987,
-0.0054701627,
-0.009776046,
0.007252356,
0.007564565,
0.013542067,
0.003899361,
0.0040749786,
0.018277239,
0.0062864595,
-0.034785293,
-0.019500056,
0.0047514313,
0.009697993,
-0.009600428,
0.012046066,
0.02250507,
0.0038310653,
-0.009580915,
0.012182658,
0.003753013,
-0.0052847886,
-0.0177699,
0.022661174,
0.01996837,
0.00061262894,
-0.021243224,
0.00053742237,
0.030700557,
-0.0075125303,
-0.012247701,
0.026199542,
0.004156283,
-0.0023919765,
-0.013854276,
-0.012579423,
0.0072458517,
0.014049407,
0.032339655,
0.04056116,
-0.028593145,
0.004042457,
-0.015779566,
0.005655537,
-0.010751699,
0.0019708197,
0.012117614,
-0.046232957,
-0.016416993,
-0.0022196113,
-0.031741254,
-0.0333023,
-0.0054116235,
-0.009880115,
-0.0030326557,
-0.0062311725,
-0.0050636404,
0.011148465,
-0.023740897,
-0.0034765778,
-0.02056677,
0.0042766137,
0.0076231044,
0.014010381,
0.008546723,
0.004208318,
-0.0016382844,
0.014504712,
-0.026849978,
-0.0055904933,
0.0017691846,
-0.019435013,
0.009249194,
0.005948233,
0.023025418,
0.0140754245,
-0.031637184,
0.0020374893,
-0.010764708,
-0.036710583,
0.008280044,
0.016560089,
0.007740183,
0.07690749,
-0.009307732,
-0.012338762,
0.024339298,
-0.027500413,
0.010459003,
-0.0118704485,
0.023519749,
-0.00908008,
-0.022648165,
0.028931372,
-0.029711895,
0.027266257,
-0.05890344,
-0.017275568,
0.034837328,
0.011896466,
0.0059612417,
0.035565816,
-0.0038961088,
0.023584792,
0.004169292,
-0.004302631,
-0.008722341,
-0.043553162,
-0.0042928746,
0.03842773,
-0.015766557,
-0.015038069,
-0.034160875,
0.0016537323,
-0.009990689,
-0.0150770955,
-0.014543738,
0.018121134,
-0.011571248,
0.0029952556,
-0.021958703,
0.0051579536,
0.0001729752,
-0.021412337,
0.02381895,
-0.002193594,
0.005967746,
0.0005670985,
-0.01512913,
0.01190297,
0.0061563724,
-0.039156217
] |
To investigate the role of TGF-β and IL-6 in myofibroblasts (MFs) - lung cancer cell interactions, lung cancer cells (Lewis and CTM-167 cell lines) were stimulated by IL-6, MF-conditioned medium (MF-CM) or MFs, with or without TGF-β signaling inhibitor - SB431542 and/or JAK2/STAT3 inhibitor - JSI-124. MFs were stimulated by TGF-β, cancer cell-CM or cancer cells, with or without SB431542 and JSI-124. Cell proliferation, the levels of cytok | [
-0.039319035,
0.0006633277,
-0.027520692,
-0.04132054,
-0.034367945,
0.0066596125,
-0.030075243,
0.0023339917,
-0.02555869,
-0.012048532,
0.011449398,
-0.0013365311,
0.027678706,
-0.006034142,
-0.011772009,
0.008315463,
0.016565086,
-0.005727991,
-0.004190651,
0.0036112678,
-0.019751692,
0.020726109,
0.003473006,
-0.008085026,
-0.0039404626,
0.004954383,
0.0037956168,
-0.042900678,
-0.028100075,
0.005652276,
0.010158954,
0.016091045,
-0.02687547,
0.015221971,
0.00077936886,
-0.0070447703,
0.00017498765,
-0.008703913,
0.037054174,
-0.008980436,
0.024676448,
0.004167607,
-0.009651993,
0.010395974,
-0.015314146,
-0.0053066215,
0.013213882,
-0.0095466515,
-0.0074463882,
-0.0044638827,
0.019462,
0.006478555,
-0.003214588,
0.0006213553,
-0.009204289,
-0.0141685475,
0.0099746045,
0.016920617,
0.015630173,
-0.010889767,
-0.011100451,
-0.009454477,
-0.034025583,
0.014866441,
-0.0020969713,
0.017697517,
0.0015636757,
0.035026334,
-0.0020015049,
0.002765237,
0.029996237,
0.030101579,
-0.024887132,
-0.010797592,
0.012390895,
-0.012357975,
-0.031444695,
-0.008756584,
-0.02770504,
-0.0007657896,
0.012700338,
-0.005132148,
-0.011172874,
0.04079383,
0.0042663654,
0.024255078,
-0.0027257334,
0.0070842737,
0.0025232788,
-0.007768999,
0.011482317,
0.016222723,
0.0038186605,
0.031497367,
-0.010106282,
0.019804364,
-0.013115124,
0.009467645,
-0.0019603556,
-0.031418357,
0.000896233,
0.0015826044,
-0.01696012,
-0.015195635,
-0.051591422,
-0.013174379,
0.010902934,
-0.011581075,
0.034868322,
-0.018540256,
-0.017934537,
0.028100075,
-0.01077784,
-0.04353273,
0.019356659,
-0.015959367,
0.0069591794,
0.013694507,
-0.018961625,
-0.003663939,
0.017829195,
0.02471595,
0.025756206,
-0.011139954,
0.027178328,
0.0063962564,
-0.009625658,
-0.019040631,
-0.03600075,
0.0114757335,
0.04287434,
-0.00074068847,
0.018421745,
0.0080323545,
-0.024676448,
-0.0050992286,
-0.011660082,
-0.03165538,
-0.025571859,
-0.013273138,
-0.00657073,
0.023056809,
0.0047239466,
-0.0015957721,
-0.027441684,
-0.0031141834,
0.03339353,
-0.018816778,
-0.011989277,
-0.022069225,
-0.009303047,
-0.03378856,
0.012338224,
-0.0025463223,
0.0024607317,
0.016525583,
-0.0050926446,
0.054514673,
-0.019593678,
-0.009941685,
0.006103273,
-0.016143717,
0.03199774,
0.020502256,
0.031049661,
0.007782167,
0.010731753,
0.0013793266,
-0.010284048,
0.016881114,
0.013036117,
0.014734763,
-0.020936795,
0.034868322,
-0.016275395,
0.0011316073,
-0.01618322,
0.007999435,
-0.0036376033,
-0.022187734,
-0.0114757335,
0.02281979,
0.023912715,
-0.015814522,
-0.01564334,
-0.0056983633,
0.018197892,
-0.034973662,
-0.00026705934,
-0.02513732,
-0.0031553328,
0.030733634,
0.007268623,
-0.031971406,
-0.6215199,
-0.028152745,
0.025229495,
0.014998118,
0.013957863,
0.01738149,
-0.003469714,
-0.008697328,
-0.014326561,
0.017789692,
-0.00836155,
0.032972157,
0.017025959,
-0.0065871896,
0.004299285,
-0.015709179,
-0.022266742,
-0.017236644,
0.004042513,
0.0027323174,
-0.018540256,
0.014418735,
0.01869827,
0.025545523,
-0.0047963695,
0.025598193,
0.039819412,
-0.015577502,
0.018816778,
0.037896913,
-0.016433408,
0.026164409,
0.009329382,
-0.0003337213,
0.0412152,
0.0034269185,
-0.011857599,
0.021279156,
0.01792137,
0.011383559,
-0.002760299,
0.00449351,
0.026914973,
0.0053527085,
-0.028152745,
0.033051167,
-0.00094478927,
0.013180963,
-0.00008512774,
0.010771256,
0.01815839,
0.01653875,
-0.031918734,
0.0009686559,
0.014537246,
0.018553423,
0.011258464,
-0.013931527,
0.014682092,
0.0052374904,
-0.0065740217,
0.02628292,
-0.014234386,
-0.00925696,
0.022595936,
-0.0031948362,
0.005520598,
0.00063411164,
0.012641083,
0.0014171839,
0.013971031,
0.03373589,
-0.005727991,
0.024650112,
0.030891648,
0.033683218,
-0.0071962,
0.023188487,
0.012259217,
-0.0016377445,
0.011297968,
-0.0065970654,
-0.01618322,
0.001092104,
0.006692532,
0.01116629,
-0.025756206,
0.01660459,
-0.020265236,
0.005971595,
0.012035364,
-0.014076373,
-0.026612114,
-0.019541008,
-0.015142964,
0.014998118,
0.020752445,
0.012469902,
0.011179458,
-0.023372836,
-0.03075997,
0.0078085023,
0.018764108,
0.001345584,
0.009230624,
-0.0031355813,
-0.047667418,
0.0099351015,
0.023083145,
-0.03039127,
0.021661023,
-0.002256631,
0.0038252445,
-0.013826185,
0.013813017,
-0.021911211,
0.016472911,
0.014682092,
0.005089353,
-0.02687547,
0.009414974,
-0.0060209744,
0.018487584,
0.011594243,
0.016459744,
0.0149322795,
0.008256207,
-0.0103235515,
-0.020647103,
0.00064439897,
-0.0059189238,
-0.0014081311,
0.01785553,
-0.024228742,
0.012015613,
-0.0026730623,
0.026190745,
-0.003993134,
0.017539503,
-0.027994731,
-0.030786304,
-0.0022204195,
0.009454477,
-0.0074595558,
0.00066291617,
-0.002436042,
-0.0027487772,
0.0062678703,
0.011949774,
-0.017658014,
-0.001352991,
-0.019593678,
-0.00065880123,
0.017407825,
0.0171313,
-0.0017266271,
0.0071632806,
-0.027731376,
-0.0004419441,
-0.011159706,
-0.013641835,
0.0065114745,
0.008486643,
-0.018579759,
-0.0026714164,
0.00027899267,
-0.0068999245,
-0.0014328207,
0.0038384122,
-0.034025583,
-0.016933784,
-0.017881865,
-0.018237395,
0.021582017,
0.0007649666,
-0.0043914597,
-0.005204571,
0.0018056339,
0.0012353038,
-0.0072291195,
0.015498495,
0.0021414126,
0.031075995,
0.024702784,
0.025282167,
0.011930022,
0.016683597,
0.0056851953,
-0.008460308,
0.025822045,
-0.041899923,
-0.0008229872,
-0.002501881,
0.0315237,
0.023702031,
-0.009520316,
0.014194883,
-0.0025068189,
-0.0099746045,
0.012733257,
-0.009000188,
0.0042038187,
0.038002256,
-0.016828442,
0.014642588,
-0.018342739,
-0.004809537,
-0.031550035,
0.02615124,
0.010791008,
-0.0038285365,
0.024821293,
-0.019988712,
-0.0018780568,
0.017473664,
0.0006312312,
-0.012608164,
-0.019817531,
0.0057411585,
-0.0186851,
-0.006248119,
0.008012603,
0.0130163655,
-0.026493603,
-0.010764672,
0.009908766,
0.0072159516,
0.0028508275,
-0.0022220653,
-0.006146068,
-0.0002664421,
0.0054152557,
0.016841609,
-0.012897856,
-0.009079195,
-0.0060045146,
-0.006623401,
-0.027336342,
0.043638073,
-0.020528592,
-0.0007579712,
0.024439428,
0.012081452,
0.008657825,
0.02299097,
-0.017960873,
0.019462,
0.0019406038,
0.0031355813,
0.02532167,
-0.012687171,
0.024702784,
-0.0068472535,
-0.0019340198,
0.0030137792,
-0.015906697,
0.012588412,
0.024386756,
0.032498118,
-0.0058860043,
0.01119921,
-0.006801166,
0.006853837,
-0.014273889,
-0.0045955605,
0.02628292,
-0.016683597,
0.007650489,
-0.012186795,
-0.0010995109,
-0.029706545,
0.007959932,
0.021279156,
-0.030443942,
0.036738146,
-0.005326373,
0.023636192,
0.010060195,
0.0061197327,
-0.00064974837,
-0.003996426,
-0.032050412,
0.022674942,
0.011034613,
-0.012397479,
-0.0018286775,
-0.027099323,
0.004707487,
-0.012634499,
0.009856095,
0.004878668,
0.008229872,
0.013549661,
-0.009520316,
-0.000128386,
0.019567342,
0.0034170428,
-0.008631489,
0.012265801,
0.0062810383,
0.004035929,
-0.023425506,
0.009434725,
-0.010079947,
0.029285176,
0.0066530285,
-0.017960873,
-0.0027487772,
-0.012766177,
-0.03434161,
-0.0141158765,
-0.008631489,
-0.0018336155,
-0.0012171981,
0.019554175,
-0.012351392,
0.016867945,
-0.017763356,
0.0070842737,
-0.008262792,
-0.010369639,
-0.05338224,
-0.0031224133,
-0.016407073,
0.019488337,
0.015353649,
-0.0071632806,
-0.0064818473,
0.0063172495,
0.0056917793,
-0.008170617,
-0.028890142,
0.004954383,
-0.0241234,
0.009131866,
0.0014048391,
-0.0009233916,
0.011745673,
-0.0035092174,
0.0167231,
-0.016867945,
-0.015472159,
-0.010527652,
-0.019343492,
0.0030137792,
0.017895034,
0.04419112,
0.029232506,
0.02125282,
0.009566403,
-0.016644092,
0.02883747,
-0.0107383365,
-0.030417606,
-0.009230624,
0.013483822,
-0.0031981282,
0.01462942,
-0.0049082953,
-0.025940556,
0.006544394,
0.010073363,
-0.007874342,
0.01832957,
0.019264484,
0.022345748,
0.013905192,
0.002259923,
-0.00034318565,
-0.014576749,
-0.01815839,
0.020094056,
0.0074661397,
-0.002571012,
0.0346313,
-0.045402557,
-0.0091713695,
-0.0143924,
0.030601956,
-0.0012772761,
-0.0001894928,
-0.01462942,
0.012489653,
-0.009382054,
-0.0028343678,
-0.022543265,
0.01385252,
-0.0059386757,
-0.0030615123,
-0.032656133,
0.0029693379,
-0.01528781,
-0.013424567,
-0.0072949585,
0.012996614,
-0.026598945,
-0.010922686,
0.015985703,
0.031207673,
0.00102215,
0.018908953,
-0.00294794,
-0.011666667,
0.031734385,
-0.024176072,
-0.024952972,
0.0014212988,
-0.040346123,
0.004167607,
-0.012687171,
0.004424379,
-0.004875376,
-0.016170053,
0.008315463,
0.005576561,
-0.0032277557,
0.008401053,
-0.011778592,
-0.0013069037,
0.010218209,
0.011844432,
0.0065180585,
-0.0107120015,
-0.011745673,
-0.0038779157,
-0.022714445,
-0.012864935,
-0.004246614,
-0.022253573,
0.0016657261,
0.013523325,
0.008888261,
-0.03563205,
0.016130548,
0.0095269,
-0.009454477,
0.023214823,
0.00036787527,
0.018303234,
0.024439428,
-0.0136155,
0.008289127,
0.0233465,
-0.020462753,
0.013279721,
-0.029048156,
0.026072234,
-0.0066760723,
-0.03407825,
-0.02108164,
0.003076326,
-0.031734385,
-0.015748683,
-0.007861174,
-0.023306997,
0.034183595,
0.0071501127,
-0.019541008,
-0.02615124,
0.004302577,
-0.010099699,
0.020173062,
-0.009276711,
-0.014721595,
-0.020857787,
0.014405568,
-0.012206546,
-0.022293076,
0.02353085,
-0.038002256,
-0.009651993,
0.032313768,
-0.01119921,
0.013095372,
-0.033156507,
0.011646914,
-0.02471595,
-0.0019093303,
-0.028310759,
-0.029548531,
-0.018803611,
-0.02084462,
0.049221218,
0.038528968,
0.0327088,
0.0067484947,
0.021002633,
-0.02102897,
-0.00021726862,
0.003142165,
-0.006998683,
0.039872084,
-0.02131866,
0.019369826,
0.015577502,
-0.007782167,
0.025071481,
-0.019896539,
0.016196387,
0.020080887,
-0.021529345,
-0.0037330699,
0.005530474,
-0.022306245,
-0.035737395,
0.015011286,
-0.0016509123,
0.010363054,
-0.042716328,
-0.011370391,
0.029811887,
0.007880925,
0.0011085637,
0.013510157,
-0.001092927,
-0.028258087,
0.021832203,
-0.02042325,
-0.02000188,
-0.0061361925,
-0.01038939,
0.0084339725,
-0.008229872,
0.008335214,
0.011390143,
0.005787246,
0.0171313,
-0.024873964,
0.00540538,
-0.0016550273,
-0.008947517,
0.0016484433,
-0.02376787,
-0.033762228,
-0.015235139,
-0.025466515,
-0.0066694883,
-0.039635062,
0.015577502,
0.0049642585,
-0.012022197,
0.013918359,
-0.0143924,
-0.009092363,
0.04342739,
-0.009303047,
0.04772009,
-0.016907448,
0.022516929,
0.019277653,
-0.0020739278,
-0.008789503,
-0.0077624153,
-0.013187546,
0.0020854496,
0.030733634,
0.029653873,
-0.013839353,
-0.023899548,
-0.0005917278,
0.028547779,
-0.011758841,
-0.007854589,
0.0115020685,
0.002376787,
0.0027504233,
-0.013180963,
-0.011712753,
-0.045297213,
0.0066530285,
-0.02287246,
0.021094808,
-0.020199398,
-0.01851392,
-0.011508653,
0.013562829,
0.0072291195,
0.006527934,
-0.00003474549,
-0.013174379,
-0.010593491,
-0.008611738,
0.0065740217,
0.009085778,
-0.022832956,
0.045402557,
0.012864935,
0.01077784,
0.006873589,
-0.010211625,
-0.0070776897,
0.00043947514,
0.005435007,
0.04155756,
0.0141553795,
0.0028607035,
0.0030104872,
-0.00094561226,
0.010619827,
-0.0112848,
0.0018188016,
0.004760158,
-0.015208803,
-0.011548156,
0.035895407,
0.024478931,
-0.031813394,
0.01576185,
-0.034236267,
-0.01089635,
-0.023570353,
-0.008743416,
0.0018253856,
-0.052697517,
-0.0008707204,
-0.0068999245,
0.027784048,
0.028152745,
-0.000047939004,
-0.0062020314,
0.0022829664,
0.04103085,
-0.018250564,
0.029364184,
-0.00013599863,
0.002699398,
-0.00603085,
-0.0007970631,
-0.0022648608,
-0.042900678,
-0.019567342,
-0.009112114,
-0.0186851,
-0.01498495,
0.0089541,
0.0075517306,
-0.0068406696,
-0.03207675,
0.031444695,
0.009421557,
0.019040631,
-0.0044572987,
0.011396727,
0.01143623,
-0.0111267865,
0.018961625,
0.01011945,
-0.004605436,
-0.00809161,
0.020923626,
-0.011330888,
0.0006703231,
-0.000050253653,
-0.019857034,
-0.011686418,
0.011534988,
-0.011133371,
0.0018862867,
-0.02089729,
-0.002442626,
-0.02478179,
0.0026730623,
0.018026711,
-0.0030483445,
-0.010435478,
0.0028014483,
0.017355153,
0.020317908,
-0.058781035,
-0.002511757,
-0.023043642,
-0.03147103,
-0.019185478,
0.0012739842,
-0.0225696,
0.02788939,
0.0025166948,
0.00883559,
-0.03170805,
-0.019685853,
-0.038792323,
-0.02680963,
0.007861174,
0.0013044347,
-0.018026711,
-0.008572235,
-0.030944318,
0.017328817,
-0.005069601,
-0.005138732,
0.016670428,
-0.022701278,
-0.0011933314,
-0.024992475,
0.029522195,
0.0077492474,
-0.016999623,
-0.02143717,
0.030470278,
-0.01170617,
-0.009052859,
0.024413092,
-0.021226486,
0.0068472535,
-0.007900677,
0.017684348,
-0.010468397,
0.011218961,
0.019435665,
-0.014339728,
0.00002026606,
0.019343492,
0.0040918924,
0.0035125094,
0.007900677,
-0.00540538,
0.012943942,
-0.010817343,
0.02042325,
-0.031734385,
0.0050268057,
-0.01714447,
0.028100075,
0.01307562,
0.0025166948,
0.0032343396,
0.013233634,
-0.010086531,
-0.0241234,
0.020396914,
0.016709931,
-0.019764861,
0.02281979,
-0.0037561136,
-0.01969902,
0.014063205,
-0.017039126,
-0.0070316023,
-0.004858916,
-0.013641835,
-0.006801166,
-0.023280662,
0.021634687,
0.00011120614,
-0.026862301,
-0.019514672,
0.002951232,
-0.014458239,
-0.02317532,
-0.012035364,
0.01564334,
-0.024913467,
-0.016788939,
0.017091798,
-0.0056391084,
0.022464259,
-0.014958615,
-0.013207299,
-0.00886851,
0.01815839,
0.20057185,
-0.024136567,
-0.004549473,
0.015603837,
-0.0065081827,
0.015129796,
0.0136155,
-0.0087697515,
-0.0063139577,
0.011857599,
0.028626787,
-0.0018862867,
-0.0008349205,
-0.00092174567,
0.019857034,
0.00192579,
-0.02836343,
-0.0009966375,
-0.037422873,
-0.016499247,
0.0036935664,
0.01420805,
0.018645598,
0.003973382,
0.012878103,
-0.010343303,
-0.028547779,
0.007485891,
0.026743792,
-0.0047930772,
-0.02807374,
0.037475545,
-0.020449586,
0.01451091,
0.0034861737,
-0.0028722254,
0.0042433217,
-0.020370578,
0.00991535,
-0.01969902,
-0.014063205,
0.008861926,
-0.023702031,
0.0141422115,
0.01236456,
0.026348758,
-0.025361173,
-0.006478555,
0.0042564897,
0.00886851,
-0.0342626,
-0.002697752,
0.021305492,
0.04013544,
0.017605342,
-0.019541008,
0.041346878,
0.007262039,
-0.005329665,
-0.00075838267,
-0.024518434,
0.008341799,
-0.018645598,
0.012423814,
-0.019962378,
0.02586155,
-0.012660835,
0.03320918,
0.010488149,
-0.0003368075,
-0.0078019183,
-0.0058860043,
-0.017947704,
0.0043223286,
-0.020199398,
-0.021871708,
0.031128667,
0.015353649,
0.018342739,
0.026888637,
0.011936606,
-0.013273138,
-0.024571106,
0.013694507,
-0.0072357035,
-0.014458239,
0.004819413,
-0.008539315,
-0.019330323,
-0.0060933973,
0.010363054,
-0.003393999,
-0.008150865,
-0.0079731,
0.034973662,
-0.014958615,
-0.023794206,
-0.009540067,
-0.009566403,
-0.0013603978,
-0.044375468,
0.06984198,
0.0027191497,
-0.014589917,
-0.008203536,
-0.008519563,
0.012410646,
-0.014379232,
-0.009869263,
0.009368886,
0.012522573,
-0.025361173,
-0.00075509073,
-0.020080887,
-0.0033610796,
0.013720842,
-0.0047404063,
-0.02126599,
0.030786304,
-0.017789692,
-0.0019373118,
-0.0084076375,
-0.0038713317,
0.005332957,
-0.01851392,
0.019093303,
0.003924003,
-0.0057378667,
-0.002436042,
-0.038370956,
-0.005079477,
0.008354966,
0.010027275,
0.008315463,
0.018369073,
-0.0056193564,
0.0047107786,
-0.0063435854,
-0.012186795,
0.0126542505,
-0.0050926446,
-0.013641835,
-0.003273843,
0.004549473,
-0.00038927293,
-0.008328631,
0.02185854,
0.007874342,
-0.012186795,
-0.009461061,
-0.012048532,
-0.026230248,
0.00074809534,
-0.030048909,
0.04574492,
-0.013082204,
0.0011785177,
-0.018197892,
0.0032310477,
0.010099699,
-0.02555869,
-0.0010567155,
0.017341986,
0.009408389,
-0.017987208,
-0.001223782,
-0.16465011,
0.026901806,
0.04132054,
-0.015011286,
0.033314522,
-0.0023981847,
-0.0065015987,
-0.01969902,
0.0036079758,
-0.003017071,
0.033051167,
0.0024821293,
-0.04479684,
0.004743698,
-0.0017496707,
0.016380737,
-0.012186795,
0.025808878,
0.016946953,
0.02544018,
0.023425506,
-0.039556056,
0.0016871237,
-0.012522573,
0.013444318,
0.005635816,
0.0007258747,
-0.012950527,
-0.021871708,
-0.0133521445,
-0.015669676,
0.013707674,
0.009092363,
-0.0287848,
0.038081262,
0.017842362,
-0.010316967,
-0.009724417,
-0.00016830087,
0.022530098,
0.035210684,
0.02388638,
0.0058761286,
0.013496989,
-0.02770504,
0.030707298,
0.015880361,
0.0052341986,
0.03284048,
-0.017592175,
0.028521445,
-0.028152745,
0.004750282,
0.011153122,
0.0014517494,
0.020094056,
0.010665914,
-0.011804928,
-0.001733211,
-0.0072225356,
-0.011218961,
-0.0060275584,
0.029364184,
-0.014524078,
-0.008651242,
-0.025782542,
-0.0029281883,
0.0020360702,
-0.034683973,
-0.00782167,
-0.030891648,
0.0023916007,
0.029732881,
-0.004559349,
0.026059067,
0.010020692,
0.0087697515,
-0.00026767657,
0.00680775,
0.013997366,
-0.02728367,
0.0141553795,
-0.026480436,
0.0006439875,
-0.0210158,
0.015182467,
0.014076373,
0.013931527,
-0.025901053,
-0.011949774,
0.025334837,
-0.014458239,
-0.007327878,
-0.00072875514,
0.020291572,
0.020344242,
-0.00079171365,
-0.0053790445,
-0.006787998,
0.008763167,
0.02167419,
-0.029416854,
-0.00604731,
0.015617005,
0.022279909,
0.0010410788,
-0.027099323,
0.010040443,
0.033525206,
-0.018342739,
-0.028205417,
-0.0020443,
-0.0013110186,
0.025637697,
-0.0072752065,
0.024939803,
-0.0014896068,
-0.008743416,
0.011883935,
-0.015156132,
0.070632055,
0.016841609,
-0.004700903,
0.034683973,
-0.009875846,
-0.023781037,
-0.122934535,
-0.034789313,
0.006241535,
0.014247554,
-0.015274642,
0.013892024,
-0.02245109,
-0.0044112112,
-0.010494732,
0.031550035,
-0.027547028,
-0.0025364466,
-0.0014056622,
0.0020772195,
0.01719714,
-0.0027323174,
0.028468773,
-0.0088092545,
-0.012542325,
0.035447706,
0.011021445,
0.0052868696,
-0.013944695,
-0.011627163,
0.007940181,
-0.00057444506,
-0.039134685,
0.03339353,
0.011646914,
0.019936042,
0.025045145,
-0.013826185,
0.02358352,
0.0013562829,
-0.015985703,
-0.008071858,
-0.002957816,
-0.031418357,
0.051933784,
-0.0009752398,
-0.0067748306,
0.0061724037,
0.003594808,
-0.0077624153,
0.00589588,
-0.0055173063,
-0.03373589,
0.01295711,
0.031155003,
-0.018856283,
-0.012028781,
-0.03444695,
-0.025348006,
-0.010205041,
0.02615124,
-0.0022105435,
-0.0045099696,
0.03241911,
-0.011574492,
-0.000055037268,
0.0040490967,
-0.0233465,
-0.011133371,
0.0000025171835,
0.017539503,
-0.01218021,
-0.008157449,
-0.031760722,
0.025690367,
-0.0099351015,
0.0055963127,
-0.010784424,
-0.039872084,
-0.018066214,
-0.022240406,
-0.010435478,
-0.017816026,
-0.027994731,
0.0114230625,
-0.038081262,
-0.02143717,
-0.016235892,
0.015656509,
-0.015906697,
0.051749434,
-0.016117381,
-0.006679364,
-0.009112114,
0.01077784,
0.006616817,
0.0033775393,
0.046192624,
0.0056753196,
-0.021213317,
0.002900207,
0.010593491,
-0.022187734,
0.004348664,
0.023728367,
0.024584273,
-0.019936042,
-0.020949962,
-0.063732125,
0.025848381,
0.0061263167,
0.012976862,
0.006534518,
-0.020554928,
-0.0021644563,
-0.014418735,
0.017104967,
0.018079383,
-0.0059781787,
0.016946953,
-0.002253339,
0.005599605,
-0.0037528216,
-0.013681339,
0.01910647,
-0.0021019094,
0.01104778,
0.02108164,
0.0034433785,
-0.015353649,
0.0029825056,
-0.0018171557,
-0.009948269,
-0.010395974,
-0.003907543,
0.03492099,
-0.024636945,
-0.022016553,
0.007341046,
-0.025980059,
-0.0028376598,
-0.004503386,
-0.013971031,
-0.037607223,
0.000737808,
0.036422122,
0.0074266363,
0.024597442,
0.017262978,
-0.036817156,
0.014023702,
0.013306057,
0.011350639,
0.00070324255,
-0.027099323,
0.014484574,
0.0056325244,
-0.0141158765,
0.0103038,
-0.0027454852,
-0.009118698,
-0.03410459,
-0.021582017,
0.0063896724,
0.010428893,
-0.016749436,
-0.022082392,
-0.002900207,
0.019080134,
0.039529722,
0.013332392,
0.016091045,
0.018671934,
-0.031392023,
-0.032656133,
0.010257713,
0.0022171275,
-0.018224228,
-0.018843114,
0.006346877,
0.012667418,
-0.012246049,
0.005148608,
0.023912715,
-0.011330888,
0.00462848,
-0.003397291,
0.020317908,
0.00913845,
-0.012377727,
-0.0022846125,
-0.0006180634,
0.018000375,
0.0063271252,
-0.009092363,
0.024610609,
0.013510157,
-0.022846125,
0.0033149924,
0.009665161,
0.015524831,
0.0035816403,
0.039977424,
0.04340105,
0.008275959,
0.018948456,
-0.019001128,
0.02437359,
0.0099614365,
-0.012851768,
-0.0126542505,
-0.005477803,
-0.019896539,
-0.003476298,
-0.013628668,
-0.03873965,
-0.014050038,
0.0047766175,
0.004035929,
0.017842362,
-0.011699586,
-0.0016813629,
-0.004500094,
0.02018623,
-0.011679834,
-0.010534236,
0.0049082953,
0.051275395,
0.011772009,
0.013549661,
0.013971031,
-0.008552483,
-0.016749436,
0.019738525,
0.04000376,
-0.02108164,
-0.0016764249,
-0.0063139577,
0.010007524,
0.017328817,
-0.03995109,
-0.009401806,
-0.0077558313,
-0.01092927,
0.010534236,
0.010922686,
-0.005010346,
0.08996238,
0.01815839,
-0.0045758085,
0.00844714,
-0.022016553,
0.011831264,
0.0060802293,
0.023083145,
-0.014537246,
-0.0404778,
0.005273702,
-0.016407073,
0.0055601015,
-0.05314522,
-0.033656884,
0.01403687,
0.00809161,
0.01272009,
0.005079477,
-0.012311888,
0.0062678703,
0.008631489,
-0.013233634,
0.001666549,
-0.021358164,
0.008223288,
0.014050038,
-0.0070776897,
-0.0043223286,
-0.028916478,
-0.022319412,
-0.00041643152,
-0.018803611,
-0.006629985,
0.029838223,
-0.016341234,
-0.008196953,
-0.010823928,
0.012983446,
0.02944319,
-0.020015048,
0.021397667,
-0.0084208045,
-0.01869827,
-0.0034960497,
-0.014352896,
-0.009072611,
-0.0025397385,
-0.013187546
] |
Although it has now been 10 years since the first cloned mammals were generated from somatic cells using nuclear transfer (NT), most cloned embryos usually undergo developmental arrest prior to or soon after implantation, and the success rate for producing live offspring by cloning remains below 5%. The low success rate is believed to be associated with epigenetic errors, including abnormal DNA hypermethylation, but the mechanism of "reprogramming" is unclear. We have been able to develop a stable NT method in the mouse in which donor nuclei are directly injected into the oocyte using a piezo-actuated micromanipulator. Especially in the mouse | [
-0.040932406,
-0.034480393,
-0.0032798823,
-0.025925599,
-0.02057069,
-0.007294432,
-0.015842697,
0.021066999,
-0.040827923,
-0.0040912814,
-0.004754115,
0.01486314,
0.013413396,
-0.012440369,
0.0062561017,
0.017070407,
0.03077114,
0.0030431561,
-0.0034872217,
-0.006288754,
-0.023875061,
-0.00060161104,
-0.009064164,
-0.002688883,
-0.009142529,
0.013583185,
0.007921348,
-0.022386136,
-0.0067001674,
-0.016365126,
-0.0010742472,
0.007294432,
-0.018964216,
-0.011597951,
-0.023208963,
-0.02698352,
0.00060773327,
-0.004943496,
0.012819132,
-0.017867113,
0.0012587303,
0.0118003925,
-0.0013991335,
0.0006036518,
-0.02403179,
0.0020227844,
-0.022777958,
0.0029288745,
0.0015166802,
-0.0051263464,
0.015281084,
0.01556842,
-0.0027150046,
0.006239776,
-0.025494594,
-0.014406013,
-0.020544568,
0.007346675,
0.02490686,
-0.011212658,
-0.01105593,
0.006158146,
-0.025925599,
0.016848374,
-0.016534917,
0.021458821,
-0.018023843,
-0.009044573,
0.0103245275,
0.001153428,
0.014850079,
0.01626064,
0.009188241,
0.00092731364,
0.024606463,
0.01761896,
-0.011454282,
0.007248719,
-0.005674898,
0.015372509,
0.018689942,
-0.006344262,
0.0071834153,
0.034793854,
0.0134395175,
0.011330205,
0.007020156,
0.017932417,
0.020531507,
0.0025615406,
0.022216344,
0.041063014,
0.0017844257,
0.023822818,
-0.01970868,
0.012936678,
-0.0029647914,
0.019460525,
-0.0036798678,
-0.017161833,
-0.0065564993,
0.006589151,
0.0025109302,
-0.027767166,
-0.016208397,
0.010102495,
0.0370403,
-0.011415101,
0.022255527,
-0.000802012,
0.0069940346,
0.039130025,
0.0003550893,
-0.013302379,
0.032965347,
0.0025272563,
0.020897208,
-0.0037484367,
-0.008136851,
0.007536056,
0.027610436,
0.01140857,
0.022555925,
-0.030849503,
0.009423335,
0.019747863,
-0.024319127,
0.01901646,
-0.009103347,
-0.0041108727,
0.01867688,
-0.020766601,
0.0008134402,
0.03719703,
-0.024371369,
0.0031247856,
-0.014510499,
-0.008600508,
-0.0015036195,
-0.021720037,
0.0061614113,
0.019460525,
0.0047606453,
0.017357744,
-0.0037027241,
0.014771714,
0.003477426,
-0.0037451717,
0.019003399,
0.008979269,
-0.0034904869,
-0.010337587,
0.024593402,
0.0040292433,
-0.00159831,
0.01674389,
0.009051103,
0.017357744,
-0.018807488,
0.00933844,
0.006549969,
0.017527534,
-0.0034121224,
0.010017599,
0.012832192,
0.038476985,
0.005240628,
0.0056814286,
0.0019248289,
-0.026957398,
-0.02092333,
0.008561325,
-0.013478699,
0.03617829,
-0.019826226,
0.0057859146,
-0.033435535,
0.009815157,
-0.03186824,
-0.016234519,
-0.010304936,
0.016156154,
0.020048259,
0.0148108965,
-0.029752402,
-0.00229053,
-0.008966208,
-0.024462795,
0.0031949873,
-0.0025843969,
-0.0020456407,
-0.00009596594,
0.00708546,
-0.0054561305,
-0.65700823,
-0.0073532052,
0.010239632,
0.0010138411,
0.019460525,
0.015594542,
0.0046920762,
-0.017174894,
-0.026643941,
0.023013052,
-0.021393517,
0.010422483,
0.023574663,
-0.017749567,
-0.018415665,
-0.03283474,
-0.0008277254,
0.00233461,
0.0013770934,
0.008228276,
-0.023039173,
-0.0014546416,
-0.021315154,
0.011388979,
0.010337587,
-0.012806071,
0.010755532,
0.016965922,
-0.016286762,
0.03978306,
-0.007157294,
0.011748149,
-0.0116501935,
-0.015450873,
0.044720028,
0.00044569827,
-0.003905166,
0.028394083,
-0.008482961,
0.035420768,
-0.015986364,
0.0011885287,
0.0093253795,
0.0071834153,
-0.014249284,
0.017684262,
-0.007712376,
-0.012564447,
-0.0042447457,
0.0018480968,
0.007555647,
0.017018164,
-0.0127538275,
0.016887557,
-0.03043156,
-0.0015689232,
0.02298693,
-0.004460248,
0.014876201,
-0.0062169195,
-0.0018203427,
-0.0039672046,
0.013922765,
-0.021706976,
-0.01901646,
0.008763767,
-0.0015550462,
0.0067850626,
-0.0077254367,
-0.019434404,
0.008528673,
0.034611,
-0.011388979,
-0.017501412,
-0.011023277,
0.048507646,
0.0045745294,
-0.0063475273,
-0.009808627,
0.011114703,
-0.013726854,
-0.019734802,
-0.010481256,
0.011891818,
0.016704706,
-0.0029909129,
-0.010422483,
0.020283353,
0.008959678,
0.00028774477,
0.0010056782,
-0.00080935867,
0.010566151,
-0.04584325,
-0.005622655,
0.0008489491,
-0.006083047,
0.0017844257,
-0.0034643654,
-0.026239058,
-0.02904712,
0.0027786756,
0.0104877865,
0.009260075,
0.024854617,
-0.014144798,
-0.040671192,
0.006883018,
0.04819419,
-0.017187955,
-0.007229128,
-0.008750706,
0.010246162,
-0.010866549,
0.007797271,
-0.021550246,
0.007451161,
0.006726289,
-0.0037059893,
-0.026500273,
0.015620664,
-0.010520439,
0.013178302,
0.008482961,
-0.008894375,
0.007157294,
-0.013400335,
-0.025311744,
-0.0007550749,
-0.015620664,
-0.01919931,
0.0058512185,
0.013126059,
-0.023222024,
0.017932417,
0.006380179,
0.014850079,
-0.00033223297,
0.017684262,
0.009789037,
-0.022203283,
0.00657609,
0.009207833,
-0.0066250684,
0.01037024,
-0.023065293,
-0.003441509,
-0.0039508785,
0.009436396,
-0.023313448,
-0.01331544,
0.0044700434,
0.019081764,
0.0010603701,
0.008691933,
-0.007209537,
-0.014471317,
-0.026826791,
-0.0030480537,
-0.01262322,
0.012655872,
0.029883008,
-0.010187389,
0.022177164,
-0.0060112127,
-0.0074381004,
-0.008437248,
0.0009844544,
-0.032024972,
-0.02284326,
0.0136484895,
-0.010089434,
0.0010726146,
0.010957974,
0.0026758222,
0.0071311723,
0.007882166,
-0.016874496,
-0.0038268014,
-0.0065336428,
-0.009945765,
-0.019982956,
-0.0059818258,
-0.013726854,
0.03369675,
0.017018164,
0.027584316,
0.0035198736,
0.0013052592,
0.035133433,
0.0028439795,
0.018911975,
-0.010775123,
0.010624925,
0.036570117,
-0.032181703,
0.005913257,
0.022020433,
0.015594542,
0.03871208,
0.017344683,
-0.009358032,
-0.00016519814,
0.0010497582,
0.012564447,
-0.02818511,
0.00458759,
-0.018010782,
-0.020805784,
0.0063214055,
-0.0026137836,
0.014993747,
0.0028766314,
-0.024371369,
0.016835313,
-0.01418398,
-0.010827366,
-0.011813453,
-0.0006709963,
0.0022578782,
0.0021631876,
-0.006363853,
0.00984781,
-0.0007179334,
0.0057304064,
0.006520582,
-0.00760789,
0.0009958826,
0.0061385552,
-0.0051459377,
0.00027019437,
0.014850079,
-0.017266318,
-0.010971035,
0.035760347,
0.0130672855,
0.011970182,
-0.017723445,
0.030875625,
0.01848097,
-0.009318849,
0.007229128,
0.023966486,
-0.010024129,
0.018703002,
0.00012122014,
0.030144224,
0.0022839997,
0.0013779097,
0.005034921,
-0.010918791,
0.014889261,
-0.025977843,
0.018768305,
0.00708546,
-0.0038431273,
-0.024697889,
-0.014406013,
0.027270857,
0.01798466,
-0.0011338368,
-0.006758941,
-0.013269727,
-0.03165927,
0.0026905157,
-0.014157859,
0.034663245,
-0.0007616053,
0.01729244,
-0.005936113,
-0.010474726,
0.008319701,
0.011232249,
-0.018128328,
0.02852469,
-0.0048945183,
0.005358175,
0.032024972,
0.032547403,
0.005256954,
-0.041898903,
-0.02595172,
0.026382726,
0.032756373,
-0.022921626,
-0.000068109795,
-0.025285622,
-0.026252119,
-0.03176376,
0.0043949443,
0.0038790444,
0.016090851,
0.008476431,
-0.0035655862,
-0.0080127735,
-0.032103337,
0.016835313,
-0.015803514,
0.021589428,
-0.010749002,
0.030483803,
-0.02266041,
-0.0062038586,
-0.0017338153,
0.030457681,
-0.0136484895,
-0.0014236224,
-0.029517308,
0.007209537,
-0.01848097,
-0.007248719,
-0.017018164,
-0.0035590557,
-0.0024080768,
-0.023417935,
-0.008691933,
-0.016469613,
0.008515612,
0.01418398,
0.0009085388,
-0.011016747,
-0.01901646,
-0.019055642,
-0.007398918,
0.04270867,
0.034010205,
0.0049728826,
0.007124642,
0.0072879014,
-0.007797271,
0.00796706,
-0.018951155,
0.02716637,
-0.01210079,
-0.004613712,
0.000075660544,
0.016273702,
-0.021223728,
0.032390673,
0.015359448,
-0.0030888687,
-0.006187533,
-0.023117537,
-0.014210102,
0.0037974147,
0.0010864916,
0.042682547,
0.03766722,
0.015411692,
-0.008371945,
0.02800226,
0.018010782,
-0.009495169,
-0.0043492317,
-0.011996304,
0.015516178,
0.008417657,
0.028106745,
0.008574386,
-0.007869105,
-0.0011828147,
-0.0009077225,
0.0022497152,
-0.00009020084,
0.0036210944,
0.031319693,
0.011526116,
-0.00846337,
0.021302093,
-0.004101077,
0.016978983,
-0.0057336716,
-0.002507665,
-0.03442815,
0.018467909,
-0.014928443,
-0.018611576,
-0.004025978,
-0.010683698,
0.027088007,
-0.010637986,
-0.018428726,
-0.013374213,
0.007895227,
-0.012603629,
-0.015189659,
0.01504599,
-0.010925322,
-0.006445483,
-0.027688801,
-0.0048292144,
0.003474161,
-0.04234297,
-0.010977565,
0.009142529,
-0.012708115,
-0.03458488,
-0.010161268,
0.008600508,
0.0050218604,
0.0032635562,
-0.008626629,
0.007745028,
0.040723436,
-0.0011387346,
-0.02195513,
-0.008972739,
-0.023026112,
-0.009129468,
0.009867401,
0.012551386,
-0.0204009,
-0.006902609,
-0.014588864,
0.014105616,
-0.018049965,
0.0016619811,
0.005844688,
-0.01521578,
0.016182275,
0.008385005,
0.026147632,
0.008574386,
-0.011937531,
0.00019815615,
-0.019395221,
-0.016952861,
-0.026069269,
-0.023444057,
-0.00029570368,
-0.008881314,
-0.0025648058,
-0.01679613,
-0.0050381864,
0.031398054,
-0.012159564,
0.008476431,
-0.0041076075,
0.008541734,
0.025037467,
0.017827932,
0.025363987,
0.01296933,
0.017031224,
0.013060755,
-0.033905722,
0.035708103,
0.022203283,
0.014497438,
0.0005363073,
0.018258937,
0.005844688,
-0.036570117,
0.018925035,
-0.00013101571,
0.027819408,
-0.009286197,
-0.03907778,
-0.014588864,
-0.03322656,
0.007986652,
0.022020433,
0.008417657,
-0.0045222864,
0.0061646765,
0.017501412,
-0.0062038586,
-0.0061940635,
0.012368536,
-0.040331613,
0.009965356,
0.015372509,
0.013400335,
0.0054332744,
0.004045569,
-0.006706698,
-0.028785905,
-0.035028946,
0.0014268876,
-0.038137406,
0.009625777,
-0.022216344,
0.033775114,
0.00881601,
0.037980676,
-0.012779949,
0.008783358,
0.0095931245,
0.01072288,
0.0051785894,
-0.0029370373,
0.028576933,
-0.0148108965,
0.009540882,
-0.013557064,
-0.019081764,
0.009756384,
-0.0062430413,
0.0011599583,
0.022346953,
-0.0019787045,
-0.01678307,
0.007895227,
-0.032808617,
-0.025808053,
-0.020531507,
0.00080119574,
-0.00081670535,
-0.022216344,
-0.004943496,
0.009547412,
0.016652463,
0.0057304064,
0.01227058,
0.02557296,
-0.018363422,
-0.008228276,
-0.012303231,
0.0040194476,
-0.005253689,
-0.0058871354,
-0.009606185,
0.0021321683,
0.007875635,
0.010598803,
0.02714025,
0.01003719,
0.00622345,
-0.0061124335,
0.02230777,
-0.017723445,
-0.019839287,
-0.0059589697,
-0.01349176,
-0.027714923,
-0.004842275,
-0.0031656006,
-0.02438443,
-0.009984948,
0.026186815,
-0.017214075,
0.017501412,
-0.0067654713,
-0.013126059,
0.011297554,
-0.0273231,
0.025220318,
-0.008254398,
0.027871652,
0.02093639,
0.004035773,
-0.045425307,
-0.027741045,
0.017697323,
0.009540882,
0.031110719,
0.018298117,
0.015516178,
-0.02766268,
0.01641737,
-0.00015336183,
-0.02196819,
-0.04289152,
0.0019052377,
-0.013948887,
-0.018925035,
-0.017201016,
-0.01624758,
-0.016090851,
0.0003152948,
-0.014784775,
0.00134036,
0.01055309,
-0.022020433,
-0.014628046,
0.017854052,
-0.0008987432,
0.0013958683,
-0.006014478,
-0.00038529228,
0.010272284,
-0.03717091,
-0.019747863,
0.0124860825,
0.006523847,
0.029334456,
-0.013883583,
-0.013530943,
0.019316858,
-0.0055116387,
-0.0071703545,
-0.027636558,
-0.0008611936,
0.036935817,
-0.0016611648,
0.0011126131,
-0.0072552497,
0.020871088,
0.0014603557,
-0.009469047,
-0.0081172595,
-0.011891818,
-0.024319127,
-0.001634227,
0.02698352,
0.01418398,
0.003079073,
-0.0050381864,
-0.02093639,
-0.008208685,
-0.029099364,
-0.024593402,
0.0008497654,
-0.016391248,
0.018689942,
0.014027251,
0.0046039163,
-0.0048292144,
-0.001271791,
0.008208685,
0.002713372,
0.047149327,
-0.0041108727,
0.019591132,
0.013001982,
0.0015640254,
-0.0124860825,
0.010304936,
-0.017331623,
-0.017684262,
-0.014053373,
-0.023052232,
-0.027192492,
0.0032619236,
0.019617254,
0.0130672855,
0.0096976105,
-0.0011550606,
0.028106745,
0.019904591,
0.014406013,
-0.030039737,
-0.015973303,
0.0013272993,
-0.0035655862,
-0.00024346064,
0.010605333,
-0.011114703,
-0.008835601,
-0.014575803,
-0.018415665,
0.0038431273,
-0.038842686,
-0.0017615694,
0.021158423,
0.013158711,
0.0013893378,
0.002889692,
-0.014366831,
0.00423495,
-0.014954565,
0.014967626,
-0.00028692847,
-0.020518446,
-0.021471882,
0.019656437,
0.005256954,
0.017409988,
-0.014458256,
-0.025207259,
-0.001400766,
-0.03615217,
-0.03928675,
-0.0062430413,
-0.017540595,
0.028080624,
0.008704994,
-0.0007942572,
-0.025468472,
-0.0015476996,
-0.030118102,
-0.029334456,
0.009109877,
0.0035917077,
0.035185676,
0.03698806,
0.0011624072,
-0.003980265,
-0.011310614,
0.013204424,
-0.018441787,
-0.030614411,
0.04218624,
-0.0020929861,
0.029334456,
0.01883361,
-0.03252128,
-0.0031688658,
0.004940231,
-0.005603064,
-0.005841423,
0.014406013,
0.0054561305,
0.03445427,
0.0057957103,
0.004221889,
0.011186537,
0.022830201,
0.016090851,
-0.024815435,
-0.011937531,
0.006500991,
-0.016195336,
-0.01140204,
-0.009090286,
-0.003204783,
-0.016025547,
0.0042806626,
-0.04477227,
0.0008358883,
0.0011248576,
-0.0070985206,
0.02403179,
0.023470178,
-0.0063083447,
0.0041859723,
0.00010443502,
-0.01934298,
-0.015072112,
-0.0032227414,
0.0022513478,
0.000030202997,
-0.010363709,
-0.013361153,
0.00398353,
0.0101155555,
0.010043721,
-0.03027483,
-0.0012603629,
0.01176121,
-0.00709199,
-0.012518734,
0.015803514,
0.02800226,
0.009521291,
0.00039121043,
0.005256954,
-0.009573534,
0.005253689,
0.001068533,
-0.008541734,
-0.016195336,
0.016195336,
0.000617937,
-0.017044285,
-0.01798466,
-0.0013983172,
-0.011571829,
-0.01884667,
0.0293867,
0.17365581,
-0.013086877,
-0.0010864916,
0.028420204,
-0.00072201487,
-0.03440203,
0.008287049,
0.0054006223,
-0.0074576912,
-0.016992042,
0.017318562,
0.017383866,
0.0030758078,
-0.006523847,
0.045869373,
-0.011225719,
-0.014575803,
-0.0018007517,
-0.009155589,
0.0057434672,
-0.011225719,
-0.02266041,
0.027192492,
-0.0033696748,
0.035394646,
0.0085352035,
-0.023809757,
0.008378475,
0.005322258,
0.007229128,
-0.021511065,
0.007346675,
0.029961374,
-0.010461665,
0.015777392,
-0.0056422465,
0.0069744433,
-0.0018970747,
-0.019225432,
-0.007189946,
-0.011042869,
0.016391248,
0.009247015,
0.0033027385,
0.00050161465,
0.039182264,
0.015803514,
-0.013060755,
-0.005123081,
-0.00967802,
-0.02889039,
0.002523991,
0.0024929717,
0.009455987,
-0.012636281,
-0.009462518,
0.021550246,
0.01020045,
-0.0027362283,
0.03437591,
-0.018572394,
0.003803945,
-0.012224867,
0.0342453,
-0.039103903,
0.022438377,
-0.004283928,
0.023039173,
0.020871088,
-0.016534917,
-0.023509359,
-0.005423479,
-0.020413961,
-0.014275406,
0.001991765,
-0.023287326,
0.040958527,
0.026879035,
0.010154737,
0.0027966343,
0.0076666633,
-0.012845253,
-0.0038594531,
-0.00984781,
0.0008277254,
-0.04223848,
0.044667784,
0.01969562,
-0.01157836,
0.003957409,
0.0039900606,
-0.0017321827,
-0.014562742,
-0.00029978514,
0.007503404,
0.000425699,
0.020466203,
0.011454282,
-0.0017076938,
-0.009090286,
-0.02471095,
0.046574652,
0.021654733,
0.014549682,
-0.0021844113,
0.019277675,
-0.015529238,
0.025899477,
-0.008685403,
-0.009312319,
0.001807282,
-0.008881314,
0.020361718,
-0.0048520705,
-0.014157859,
0.030196466,
-0.0031770288,
-0.040201005,
0.033331048,
-0.010011069,
-0.0060993726,
-0.032469038,
-0.002065232,
0.015254962,
0.0018987074,
0.004372088,
-0.020126624,
0.021811461,
-0.0054202136,
-0.030666653,
-0.006967913,
-0.007385857,
-0.022869382,
0.0041729114,
-0.0045386124,
-0.0106967585,
0.0034676306,
0.0009583329,
-0.024123216,
-0.0052634845,
-0.013596246,
0.013909704,
0.0052308324,
-0.0121726245,
-0.0007918083,
-0.02766268,
0.02267347,
0.030300952,
-0.028759783,
-0.011349796,
-0.015359448,
-0.0019248289,
0.006001417,
-0.005482252,
0.023130598,
-0.016208397,
-0.030118102,
-0.029543428,
-0.029621793,
0.014157859,
-0.04411923,
0.020949451,
0.011447752,
-0.013504821,
-0.0046235076,
-0.0038986355,
-0.16362514,
-0.017096529,
0.020322535,
-0.047750123,
0.038163528,
-0.0007236475,
0.013975008,
0.0032096806,
-0.010762063,
-0.020035198,
0.019617254,
0.017827932,
-0.04458942,
-0.0134395175,
0.005305932,
0.022634288,
-0.024097094,
0.032024972,
0.018716063,
-0.009410274,
0.033984084,
-0.03385348,
0.018781366,
-0.014223163,
0.021066999,
0.027453708,
0.0127538275,
-0.03215558,
0.0045777946,
-0.036282778,
-0.025324805,
0.0014872935,
0.0005893666,
0.004786767,
0.019238492,
0.003803945,
0.025625203,
-0.013387274,
-0.002254613,
0.020283353,
-0.011852635,
0.009919643,
-0.010644516,
-0.022908565,
0.0008758869,
0.02366609,
-0.011369388,
-0.028158989,
0.032416794,
0.01072288,
0.009743324,
0.000114077535,
0.002639905,
0.0037810886,
0.019656437,
-0.001919931,
0.019290736,
0.011617542,
0.012224867,
0.005622655,
-0.0065956814,
-0.016352065,
0.029020999,
0.0035166084,
-0.02124985,
-0.030300952,
-0.007176885,
0.01660022,
-0.032756373,
-0.017240196,
-0.025677444,
0.0099065825,
0.010043721,
-0.02630436,
0.034898337,
0.0037451717,
-0.005149203,
0.008907435,
0.012714645,
-0.012120381,
-0.03249516,
0.021014756,
0.00015121906,
-0.010886139,
-0.01883361,
0.005374501,
0.03009198,
0.01660022,
-0.008593977,
-0.004509226,
0.014967626,
-0.028132867,
0.015620664,
-0.0058022407,
0.027114129,
0.010206981,
-0.0065956814,
-0.006592416,
0.0020880883,
-0.013844401,
0.005648777,
-0.007653603,
-0.011323675,
-0.005217772,
0.051302645,
-0.0050055343,
-0.026474152,
0.007869105,
0.028158989,
-0.0018856466,
-0.004636568,
0.002661129,
-0.010866549,
0.034637123,
-0.0012603629,
0.035028946,
0.015372509,
0.0070789293,
0.015476995,
-0.019565012,
0.05341849,
-0.0069417916,
-0.015842697,
0.026056208,
-0.0019787045,
0.0014154593,
-0.13823503,
-0.020701297,
-0.007842984,
0.039678574,
-0.012120381,
0.022947747,
-0.0024521567,
0.038503107,
-0.03249516,
0.032286186,
-0.013896644,
-0.0293867,
0.0017615694,
0.0006477318,
0.016587159,
0.017018164,
-0.0040586297,
0.007862574,
0.001972174,
0.032599647,
0.018219754,
-0.010291875,
0.0065630297,
-0.030901747,
-0.008110729,
0.007281371,
-0.030901747,
0.024149336,
0.008515612,
0.02643497,
0.024319127,
-0.01798466,
0.014210102,
-0.020975573,
-0.023809757,
-0.007052808,
-0.035708103,
-0.008718054,
0.024462795,
-0.0074576912,
-0.025194198,
0.0054691914,
0.0031002967,
0.008698463,
0.0112779625,
-0.014902322,
-0.019147068,
0.005044717,
-0.012982391,
-0.023143658,
-0.036570117,
0.009919643,
-0.0095343515,
0.020688236,
0.007705846,
-0.02766268,
0.014458256,
-0.0061810026,
-0.022164103,
0.010206981,
-0.012309762,
0.004326375,
-0.0049010483,
-0.016887557,
0.017945478,
-0.014654168,
-0.027636558,
-0.017553655,
0.019747863,
-0.019120947,
-0.010069842,
0.020975573,
-0.000034973233,
-0.03442815,
-0.024488917,
-0.0119636515,
-0.008933556,
-0.0046267724,
0.006967913,
-0.0047475845,
-0.0069940346,
-0.014745593,
0.014654168,
0.0061156987,
0.01692674,
0.024188519,
0.00864622,
-0.0033157992,
-0.003067645,
-0.00916865,
-0.020910269,
0.004283928,
-0.038268015,
-0.032181703,
0.011931,
0.0070266863,
-0.025181137,
0.004737789,
0.04963087,
-0.0021958395,
-0.03150254,
-0.033670627,
-0.044354327,
0.013687671,
0.0063605877,
-0.01816751,
-0.0054561305,
-0.0016187173,
0.008724584,
0.010442073,
0.020818844,
0.018585455,
-0.017919356,
-0.012551386,
-0.027427586,
-0.012459961,
-0.01418398,
0.0025337865,
0.024802374,
0.003803945,
0.0019836023,
0.017436108,
0.012904027,
-0.015359448,
0.0034904869,
0.026722306,
0.016365126,
-0.004179442,
0.0018791162,
0.018036904,
0.0113824485,
0.008633159,
0.009475578,
-0.02612151,
-0.008783358,
0.0012913822,
-0.009455987,
-0.016952861,
0.0033762052,
0.007176885,
0.028838148,
0.04892559,
-0.017710384,
-0.009619246,
-0.015620664,
0.0024488915,
-0.0012268947,
0.0018905443,
-0.021354334,
0.008456839,
0.007829923,
-0.012538325,
0.037144788,
-0.0018578925,
0.006497726,
-0.010109025,
-0.034297545,
-0.0041239336,
-0.004424331,
0.013909704,
-0.023274265,
-0.018023843,
0.038241893,
-0.0048324796,
0.012224867,
-0.008887844,
-0.017671201,
-0.01919931,
-0.020714357,
0.014745593,
0.020779662,
-0.01679613,
-0.024136275,
0.02575581,
0.026082328,
-0.002496237,
-0.031110719,
-0.005828362,
-0.025468472,
0.018219754,
-0.021171484,
0.013883583,
-0.008176032,
-0.0034839564,
-0.030118102,
0.00039080228,
0.03790231,
0.015816575,
0.0007456875,
0.021406578,
-0.005100225,
0.019408282,
0.0031656006,
0.008202154,
-0.0001087716,
0.001493824,
-0.002861938,
0.031345814,
-0.0003573341,
0.014105616,
0.007823393,
0.0050120647,
0.0043459665,
-0.0025729688,
0.024449734,
-0.02836796,
-0.018311178,
0.030457681,
-0.04187278,
-0.049343534,
-0.01020045,
0.011931,
0.008489491,
0.023222024,
0.008665811,
0.006778532,
-0.029438943,
0.016090851,
-0.0022709388,
-0.031058475,
-0.027453708,
0.020805784,
0.010566151,
0.007281371,
0.008613568,
-0.0043296404,
0.018820548,
-0.00050528796,
0.023117537,
-0.0355775,
0.009612716,
-0.001964011,
0.026879035,
0.006314875,
-0.02627824,
-0.012956269,
0.006902609,
-0.019996017,
0.0075948294,
-0.0062724277,
-0.0075099343,
0.058355454,
0.001123225,
-0.01383134,
0.0067654713,
-0.015032929,
0.025703566,
0.018454848,
0.021602489,
-0.011748149,
0.0007505853,
0.0439625,
-0.031006234,
0.02886427,
-0.011780801,
-0.004375353,
0.011434691,
-0.022216344,
0.0041337293,
-0.016665524,
-0.01592106,
0.0074250395,
-0.027401464,
0.0007893594,
0.021132302,
-0.0060863122,
0.023718331,
0.031580906,
-0.0035133432,
0.002359099,
0.0049206396,
0.00882254,
0.0027950017,
-0.04077568,
0.01019392,
-0.012205276,
0.016012486,
-0.009795566,
-0.007986652,
0.012681994,
0.0019019725,
-0.0046300376,
0.008378475,
-0.011212658,
-0.025533777,
-0.0065989466,
-0.017501412,
-0.004613712,
-0.0020538038,
-0.00985434
] |
The Tat protein of human immunodeficiency virus type 1 (HIV-1) plays a key role as inducer of viral gene expression. We report that Tat function can be potently inhibited in human microglial cells by the recently described nuclear receptor cofactor chicken ovalbumin upstream promoter transcription factor-interacting protein 2 (CTIP2). Overexpression of CTIP2 leads to repression of HIV-1 replication, as a result of inhibition of Tat-mediated transactivation. In contrast, the related CTIP1 was unable to affect Tat function and viral replication. Using confocal microscopy to visualize Tat subcellular distribution in | [
-0.046404365,
-0.007244898,
-0.011673804,
-0.022964211,
-0.0044487375,
0.00900985,
-0.013815545,
0.017861053,
-0.03299866,
0.0014666622,
0.018336995,
-0.0045346715,
-0.0030490046,
0.0033976985,
-0.016327461,
0.009406469,
0.021642148,
-0.013789103,
-0.005830292,
-0.0010518653,
-0.037414346,
0.02078281,
-0.009069343,
-0.01562677,
-0.022607254,
0.019923469,
0.023678124,
-0.05658424,
-0.024035081,
-0.022170974,
0.00050899375,
-0.0051758713,
-0.022118092,
-0.007542362,
-0.010384794,
-0.018403098,
0.0003862899,
-0.025185274,
0.024365596,
-0.0022144532,
0.019606175,
0.01845598,
0.0012080339,
0.0025036542,
0.013147904,
-0.00047098447,
0.013736221,
-0.0053312136,
-0.019923469,
0.024947304,
0.011693635,
0.014727767,
-0.0056551187,
-0.0048056943,
-0.018998027,
-0.008818151,
0.0049180696,
0.01716036,
0.005268416,
-0.029455533,
-0.008626453,
-0.0071259122,
-0.023757448,
0.0077340608,
0.006573952,
0.020848913,
0.008467805,
0.009148667,
-0.0011435833,
0.021073664,
0.045954864,
0.026877513,
-0.0012014236,
0.009128836,
0.030989125,
-0.014952517,
-0.05063496,
0.01587796,
0.015521004,
0.011528377,
0.04074594,
-0.01307519,
-0.0026854377,
0.01844276,
0.025013406,
0.009287483,
0.012533144,
0.03373901,
0.03191457,
-0.011667194,
0.02575376,
0.015415239,
0.017371891,
0.03175592,
-0.02337405,
0.037255697,
0.012202629,
0.034796663,
-0.0037017725,
-0.021933002,
-0.014317928,
-0.0020227544,
-0.015045062,
-0.019870587,
-0.026626322,
0.0074498174,
0.018284112,
-0.009075954,
0.008851203,
-0.003582787,
-0.030566065,
0.030063681,
-0.006881331,
-0.04627216,
0.03365969,
0.026745308,
0.00546342,
0.002188012,
-0.0035860923,
-0.009161888,
0.019606175,
0.02916468,
0.014754208,
-0.006633444,
0.034849547,
0.016420005,
0.004808999,
-0.006197164,
-0.017014934,
-0.01072192,
0.021985885,
0.008447974,
0.011389561,
0.010893788,
-0.022567593,
-0.0006878852,
-0.026613101,
-0.01458234,
-0.013485029,
-0.009142056,
0.0074498174,
0.023638463,
0.007813385,
0.008652894,
0.012929763,
0.019183114,
0.009532064,
0.02057128,
0.0053047724,
0.020862132,
0.00039475935,
-0.017953597,
0.012579417,
-0.0113499,
-0.008269495,
0.010907008,
-0.021800797,
0.019328542,
0.0015906055,
-0.030618949,
0.011799401,
-0.008547128,
0.008897475,
0.014701325,
0.031174215,
0.027393118,
-0.001125405,
0.0025036542,
-0.0015773848,
-0.02272624,
0.010893788,
-0.0038868613,
-0.01565321,
0.012387718,
0.0022441996,
0.009710543,
-0.0089767985,
0.035880752,
-0.021642148,
-0.0151640475,
-0.024325935,
0.017821392,
0.03405631,
0.003728214,
-0.019341761,
-0.015825078,
0.016393565,
-0.0119183855,
-0.021642148,
-0.011065656,
-0.008038135,
0.001918642,
0.01158126,
-0.019949911,
-0.6328974,
-0.012354666,
0.023823552,
-0.020452294,
0.01948719,
0.008097627,
0.025925629,
-0.0009295746,
-0.019249218,
0.032760687,
-0.015745753,
0.0125992475,
0.00857357,
-0.021536384,
-0.019447528,
-0.04743557,
-0.027313793,
-0.010510391,
0.024590347,
0.012989256,
-0.01649933,
-0.009029681,
0.0067623453,
0.02979927,
0.016591873,
0.0028804417,
0.026110718,
-0.020875353,
-0.012738064,
0.031227097,
-0.01760986,
0.034452926,
-0.008547128,
-0.012387718,
0.043892447,
-0.0010551704,
-0.0039232178,
0.01653899,
0.008778489,
0.019659057,
0.011462275,
-0.010034448,
0.009988176,
0.0129760355,
-0.008699166,
0.015494563,
-0.01415928,
0.0025499265,
-0.0016624925,
-0.02144384,
0.01158126,
0.009532064,
-0.013696559,
-0.0057344423,
-0.004842051,
-0.013260279,
0.022990651,
-0.037599433,
0.026256144,
0.0038967768,
-0.004121527,
0.023334388,
-0.008606621,
-0.006841669,
-0.0033481212,
0.017345449,
-0.013683338,
0.013736221,
-0.006920993,
0.016776962,
0.009327145,
0.02552901,
-0.009241211,
-0.00005094585,
-0.0020293647,
0.033421718,
-0.006200469,
-0.03495531,
-0.00029250613,
0.012777726,
-0.008282716,
-0.0016038261,
-0.02765753,
-0.0070862505,
0.0052717207,
-0.00014614979,
-0.04479145,
0.035854314,
0.008051355,
0.008005084,
0.013028918,
-0.006240131,
-0.009988176,
-0.02940265,
-0.024603568,
0.011065656,
-0.012242291,
-0.005549354,
-0.011429223,
-0.0036621108,
-0.00246895,
-0.013002477,
0.004442127,
0.0062731826,
0.019579733,
0.0070003164,
-0.022660136,
0.01456912,
0.040217116,
-0.021972666,
-0.021271972,
-0.007271339,
-0.00048957596,
-0.016578654,
0.011601091,
-0.021245532,
0.029349769,
0.019817704,
0.0027482356,
-0.014859973,
0.0063987784,
-0.007872877,
0.005506387,
-0.0054832506,
0.014331148,
0.022118092,
0.0057575786,
-0.015150826,
-0.019870587,
-0.009565116,
-0.0014906245,
0.0002714358,
0.008514077,
-0.012427379,
0.038947936,
-0.00041025225,
0.019434307,
0.009181718,
-0.007952201,
-0.022620475,
-0.019883808,
-0.017094256,
0.0017500791,
0.010840906,
0.008871034,
-0.02422017,
0.0052221436,
-0.00568156,
-0.00039641192,
0.01180601,
0.021866899,
-0.005106463,
-0.001738511,
0.001414606,
0.040269997,
-0.020848913,
-0.018389877,
-0.02316252,
-0.009062733,
0.0009717153,
-0.00922138,
0.021814017,
0.015587107,
-0.0068152277,
-0.006795397,
-0.005103158,
-0.0031448542,
0.002219411,
-0.023783889,
-0.041750707,
0.019976351,
-0.03064539,
-0.016155593,
0.012414159,
-0.0045115356,
0.01927566,
0.0055229124,
-0.0024441616,
-0.0150186205,
-0.009829529,
-0.002219411,
0.00020027168,
0.0043396675,
-0.018707173,
0.024537465,
0.00056518137,
-0.0018062667,
-0.000032044503,
0.011944827,
0.030830478,
-0.020452294,
0.009036291,
-0.015415239,
0.030407418,
0.012268732,
-0.013881647,
0.034135632,
0.023532698,
0.0056914752,
0.027710412,
-0.010655817,
-0.009042902,
0.0038934716,
-0.02550257,
0.008613232,
-0.014331148,
-0.010087331,
-0.02575376,
0.0002423091,
-0.011720076,
0.008844593,
-0.008771879,
-0.017451214,
0.0043859393,
0.009327145,
0.014225383,
-0.011343289,
0.0020326697,
-0.002875484,
-0.037202816,
-0.004587554,
0.019566512,
0.009439521,
-0.020042455,
-0.0018740224,
0.019434307,
0.009525455,
0.0024871286,
0.000012232944,
-0.008091018,
-0.0022656831,
-0.011006163,
0.01586474,
0.0129760355,
0.005496471,
-0.018839378,
0.00025098515,
-0.0043727187,
0.036991283,
0.0039298283,
-0.010543441,
0.0035695664,
-0.019592954,
-0.007899319,
-0.0025251377,
0.00027928554,
0.017437993,
0.006821838,
-0.02099434,
0.029323328,
0.011025994,
0.0067887865,
-0.023731006,
-0.019804483,
-0.0033233324,
-0.0009923725,
0.00072176306,
0.01735867,
0.04891628,
0.014397251,
0.023255065,
-0.026097497,
0.01008072,
0.0009981565,
-0.0053246035,
0.01393453,
0.0010551704,
-0.017014934,
-0.013405705,
0.008652894,
-0.028239237,
-0.0026110718,
0.013141293,
-0.021946223,
0.02445814,
0.01909057,
0.00005494819,
0.0089767985,
0.009948514,
0.012790946,
-0.016327461,
-0.031385742,
0.034188513,
0.015996946,
-0.004613995,
0.0029680284,
-0.018469201,
-0.004521451,
-0.00728456,
-0.0018905482,
-0.005311383,
0.015904402,
0.028450767,
0.017266124,
-0.029719947,
-0.017226463,
0.028635856,
-0.0077472813,
0.007013537,
-0.0018591492,
0.00536096,
-0.005853428,
-0.016962051,
0.0023615325,
0.031174215,
0.0050337496,
0.016010167,
-0.0107880235,
-0.018535305,
-0.017001713,
0.025621556,
0.006580562,
-0.006064958,
-0.02763109,
0.002371448,
0.013042138,
-0.0019434306,
0.0009766731,
0.0074498174,
-0.005192397,
-0.016869506,
-0.021946223,
0.003192779,
-0.0022640305,
0.015349136,
0.023083197,
0.006259962,
0.0036158387,
-0.012916543,
0.020306867,
0.003095277,
-0.044500597,
0.010378184,
-0.021800797,
-0.012420769,
-0.012837219,
-0.0047495067,
-0.0026143768,
0.021946223,
0.022408945,
-0.00083124626,
-0.017966818,
0.003387783,
0.008474415,
0.013438757,
0.010966501,
0.0028540005,
0.028424326,
0.03728214,
-0.0044917045,
0.025330702,
0.041327648,
0.0027498882,
-0.03344816,
0.015415239,
0.000988241,
-0.005403927,
0.017649524,
-0.0027614562,
-0.04479145,
-0.018350216,
0.009439521,
-0.0039761006,
0.004095086,
0.018998027,
0.024325935,
0.005509692,
-0.0021152988,
-0.0053973165,
0.003909997,
0.013828765,
0.0017054596,
-0.018323775,
-0.02377067,
0.011204473,
-0.00008588236,
-0.022554372,
-0.016340682,
-0.013485029,
-0.011905165,
-0.0026672594,
-0.01007411,
-0.010569883,
-0.017781729,
-0.021086883,
-0.024193728,
0.006623529,
-0.015732534,
0.0006354159,
-0.0077340608,
0.012182798,
-0.024193728,
0.01585152,
-0.022157753,
0.026970059,
-0.042200208,
-0.020240763,
0.014503016,
0.006967265,
0.019976351,
0.004088476,
-0.0011444096,
-0.0015575539,
0.011693635,
-0.018125465,
-0.019830925,
-0.016895948,
-0.03752011,
0.011938217,
-0.012506703,
0.012738064,
-0.03368613,
0.00029457186,
-0.01029225,
0.017081037,
-0.0064186095,
0.025621556,
0.0021599182,
-0.0050899372,
0.027551765,
0.013762662,
0.016115932,
-0.003384478,
-0.009584947,
-0.021073664,
-0.025846306,
-0.0016955441,
-0.015587107,
-0.015124385,
-0.013775882,
0.0128173875,
0.01287688,
-0.026322247,
-0.02937621,
0.020941457,
0.00022846878,
-0.023664903,
0.0029630708,
0.00834882,
0.031993892,
0.011197862,
0.0039364384,
0.0007597723,
-0.018218009,
-0.023083197,
-0.002938282,
0.010431066,
0.0065970877,
-0.01566643,
0.0024193728,
0.009241211,
-0.012110085,
-0.004412381,
-0.01114498,
-0.024140846,
0.014225383,
0.017028155,
-0.0257141,
-0.026242923,
0.0011212735,
-0.0154549,
-0.005618762,
0.022184195,
-0.018627848,
-0.010160044,
-0.01694883,
-0.007634906,
-0.0141063975,
-0.005403927,
-0.03405631,
-0.0022326317,
0.03088336,
0.0051130736,
0.0075026997,
0.015587107,
0.0038505045,
-0.028609414,
0.0032076521,
-0.02014822,
-0.038022492,
-0.001431958,
-0.008474415,
0.017887494,
0.0054997765,
0.05055564,
-0.0024325934,
0.010021227,
0.016843066,
0.02420695,
0.018998027,
0.006309539,
0.014436914,
-0.017543757,
-0.002832517,
0.005615457,
-0.0043991604,
0.022898108,
-0.0069606546,
-0.01562677,
-0.0073572733,
-0.012731453,
-0.0058203763,
0.017649524,
-0.018535305,
-0.030275213,
0.02250149,
-0.012777726,
0.002769719,
-0.03106845,
0.0070003164,
0.03365969,
0.0147145465,
0.023122858,
0.018125465,
0.013438757,
0.0026094192,
0.030090123,
-0.011911776,
-0.0052188383,
-0.0060352115,
-0.0028556532,
0.013604014,
0.01199771,
0.04013779,
-0.00772084,
-0.0087454375,
-0.0037216037,
-0.012500093,
-0.0005804677,
0.033553924,
-0.0077671125,
-0.0034638015,
-0.023598801,
-0.025978511,
-0.023122858,
-0.026520558,
-0.02786906,
-0.040349323,
0.00090065453,
-0.0029762913,
-0.011634142,
0.008130679,
0.015891181,
-0.0065012383,
0.030513182,
-0.015891181,
0.031359304,
-0.031042008,
0.033051543,
0.031174215,
0.014331148,
-0.028345002,
-0.02166859,
0.0060120756,
0.016962051,
0.027816176,
0.030328095,
0.0041876305,
-0.016221697,
0.01437081,
0.019407865,
-0.013194175,
-0.028397884,
0.016644755,
-0.026322247,
-0.0027564985,
-0.0167373,
-0.0023598801,
-0.019341761,
0.01158126,
-0.01669764,
0.017874274,
-0.017596642,
-0.020227544,
-0.041539177,
0.010959891,
0.01414606,
0.02079603,
0.0010783066,
-0.012850439,
-0.02829212,
-0.040032025,
0.012572806,
0.0020491956,
-0.0024193728,
0.017081037,
0.0070201475,
0.0023383966,
0.005403927,
-0.002230979,
0.0069143823,
0.012361277,
-0.003966185,
0.042094443,
-0.000011290458,
-0.01608949,
-0.0066598854,
0.0033200274,
0.008646283,
0.00077629805,
-0.00027122922,
-0.017186802,
-0.04090459,
-0.006954044,
0.017014934,
0.026692424,
-0.02679819,
0.01607627,
-0.020716706,
0.0033514262,
-0.046087068,
-0.026520558,
0.01480709,
-0.039794058,
-0.0031481592,
0.0011584566,
0.0033943933,
0.004395855,
0.036118723,
0.0133528225,
0.010364964,
0.040560853,
-0.025978511,
0.029455533,
-0.008071186,
0.032311186,
-0.032522716,
-0.005341129,
-0.022197416,
-0.014886415,
0.0038835562,
-0.024286272,
-0.028371444,
-0.0068681105,
-0.006372337,
0.00856696,
0.024273053,
-0.003172948,
0.043654475,
0.0030490046,
0.010113772,
-0.0012956205,
0.0008229834,
0.009327145,
-0.022408945,
0.0067491247,
0.0107153095,
-0.008514077,
-0.0028606108,
-0.013134683,
0.011878724,
0.013180954,
-0.0467481,
-0.017067816,
-0.02162893,
0.0038934716,
-0.0017038069,
-0.00058501225,
0.013643676,
0.0047891685,
0.00061269297,
0.014198942,
-0.011673804,
-0.002938282,
-0.016790183,
0.0006511154,
-0.019183114,
0.003946354,
-0.013240447,
-0.0036092284,
0.009380028,
-0.03794317,
-0.0231493,
0.0111582,
-0.026401572,
0.021298414,
0.0030589201,
-0.024471361,
-0.039370995,
-0.018072583,
-0.044685684,
0.0036786366,
-0.000108037224,
-0.0056055416,
-0.006283098,
-0.00038587674,
-0.026679205,
-0.014503016,
0.00097006274,
0.026903955,
0.006987096,
-0.00396288,
0.0072052362,
-0.013451978,
0.0033976985,
0.022012327,
-0.020320088,
-0.014357589,
0.035907194,
-0.008031525,
-0.015745753,
0.025925629,
-0.021430619,
0.008659503,
-0.012711623,
0.013253668,
0.006666496,
0.008057966,
0.025555452,
-0.008401702,
-0.0064252196,
0.016406786,
0.010748361,
-0.010556662,
-0.0039562695,
-0.0086859455,
0.027789736,
-0.0060186856,
-0.024669671,
-0.024101185,
0.0026821326,
0.0054568094,
0.014846752,
0.030962683,
0.008203393,
-0.008666114,
0.014317928,
0.00015420609,
-0.01029886,
0.0045346715,
-0.02012178,
-0.015256591,
0.024312714,
-0.0010783066,
0.0053279083,
0.016182035,
0.009783256,
-0.021166207,
0.0071986257,
0.0073440527,
-0.019169893,
-0.023942536,
0.0046635726,
0.0128306085,
-0.012942984,
0.015692871,
-0.010761582,
-0.0011039214,
-0.032496277,
0.0056782546,
-0.012625689,
-0.013762662,
-0.0049643414,
-0.0048387456,
0.0013666812,
0.004908154,
-0.019619394,
0.0075621926,
0.0001964501,
0.016975272,
0.19344406,
-0.010523611,
-0.0014790564,
0.0011064004,
-0.035669222,
0.021377737,
0.010900399,
-0.010801244,
0.0064648814,
0.0031531171,
0.010345132,
0.02078281,
0.0038868613,
0.0022028852,
-0.008553739,
-0.011905165,
-0.015031841,
-0.016671197,
-0.038260464,
-0.016221697,
0.019606175,
0.0070598093,
0.027525324,
-0.003141549,
0.04138053,
0.0014881457,
-0.03535193,
-0.008057966,
0.021800797,
-0.014132839,
-0.043733798,
0.0051196837,
0.008705776,
-0.00707964,
0.006987096,
0.020082116,
-0.034638014,
0.008619842,
-0.0035960076,
-0.010887178,
-0.0071325228,
0.011422613,
-0.025912408,
-0.013696559,
0.01027903,
0.021946223,
0.0014716199,
-0.018826159,
0.0042801746,
0.009809697,
-0.031941008,
-0.012083643,
0.006557426,
0.014661664,
-0.012394328,
-0.0037877066,
0.02913824,
-0.005985634,
-0.011812621,
0.042068,
-0.01714714,
0.011852283,
-0.018059362,
0.014595561,
-0.020531617,
0.036568224,
-0.006474797,
-0.0006102141,
0.013749441,
-0.029217562,
0.026216483,
-0.0086000115,
-0.014674884,
-0.0017599945,
0.0015674693,
-0.009578337,
0.017319007,
0.017239684,
0.01735867,
0.024418479,
0.017861053,
-0.0015038451,
-0.031570833,
0.025462907,
-0.00087586587,
-0.015243371,
0.023731006,
0.0063558114,
-0.017887494,
0.0175702,
0.007740671,
-0.022845225,
-0.010351743,
-0.0020458903,
0.005337824,
-0.0053246035,
-0.011964658,
-0.023691345,
0.006775566,
-0.020478735,
-0.027578207,
0.05275026,
0.02531748,
0.0110920975,
0.010959891,
-0.0005738574,
0.008038135,
-0.020505177,
0.0055691847,
-0.034638014,
0.006795397,
-0.023347609,
0.006451661,
0.006276488,
0.0049577313,
0.013921309,
0.00042016772,
-0.011125149,
0.047250483,
-0.0051130736,
0.01566643,
-0.03543125,
-0.012427379,
0.023030315,
-0.015745753,
0.0072118463,
-0.03640958,
0.0032754077,
-0.010371573,
-0.037546553,
0.026652763,
0.0036059231,
-0.003316722,
0.017398331,
0.011052435,
-0.018178347,
0.0045578075,
-0.029429093,
-0.02530426,
0.02527782,
-0.007839826,
-0.013108241,
0.017398331,
-0.00012786814,
-0.012275343,
-0.028582973,
0.00815712,
-0.0066301394,
-0.0042173765,
-0.01952685,
0.004544587,
-0.0150053995,
0.015838299,
-0.007396935,
-0.0007308522,
-0.027393118,
0.005103158,
-0.020518396,
-0.013187565,
0.008593401,
-0.025595114,
0.009545285,
0.014476575,
-0.016763741,
-0.014463355,
0.0077671125,
-0.16583942,
0.012790946,
0.008335599,
-0.014886415,
0.028582973,
0.0145558985,
0.012552976,
0.0071259122,
-0.008679335,
0.012665351,
0.01868073,
0.0028903573,
-0.02913824,
-0.009591557,
0.008481026,
-0.019394644,
-0.036753315,
0.00921477,
0.034003425,
0.0018674121,
0.042491063,
-0.016843066,
0.02726091,
-0.0106425965,
0.0004470221,
0.019130232,
0.0052188383,
-0.013841986,
0.0040917806,
-0.01716036,
0.0007548146,
0.012612469,
0.034849547,
-0.016605094,
0.035087515,
0.0036323643,
0.0075026997,
-0.009274263,
-0.012176188,
0.0048817126,
0.032681365,
0.021100104,
-0.009743595,
-0.021972666,
-0.0086000115,
0.022250298,
-0.007945591,
0.0010857432,
0.026652763,
0.0031035398,
0.038260464,
-0.017279346,
0.032681365,
0.02726091,
0.0205845,
0.00059410144,
0.005030445,
0.0037513499,
0.0014550941,
0.010391405,
-0.024392037,
-0.0017980038,
0.037916727,
-0.02016144,
0.010272419,
-0.045637567,
-0.0063822526,
-0.01179279,
-0.013604014,
0.009373417,
-0.027102264,
0.015375577,
0.004732981,
-0.012936373,
0.011905165,
0.035616342,
-0.020941457,
0.009122225,
-0.0073242215,
0.011356509,
-0.03596008,
-0.0011568039,
-0.028371444,
-0.019368203,
-0.02916468,
-0.0013980801,
0.0048123044,
0.0013906437,
-0.006045127,
-0.012625689,
0.00986258,
-0.0167373,
-0.011263966,
-0.0175702,
0.030513182,
0.023942536,
0.020439073,
0.02527782,
-0.009313924,
-0.009988176,
0.024193728,
-0.032020334,
-0.00536757,
-0.005489861,
0.025039848,
-0.004759422,
-0.03453225,
0.0048056943,
0.049048487,
0.010669038,
0.0003119239,
0.017966818,
0.005939362,
0.01651255,
-0.003427445,
0.026877513,
-0.018403098,
0.004894933,
0.0001971731,
-0.023545919,
0.07139133,
0.0046668774,
-0.016393565,
0.017887494,
-0.025846306,
-0.02551579,
-0.12543721,
-0.027683971,
0.025224937,
-0.012804167,
-0.02079603,
0.028265677,
-0.0020921626,
0.021999106,
-0.0069804857,
0.022250298,
-0.01672408,
-0.031782363,
0.002794508,
-0.0067491247,
0.0062269103,
0.009803087,
0.014846752,
-0.012757895,
-0.023519477,
0.032549158,
0.011634142,
0.0024375513,
0.016565433,
-0.0150053995,
0.0037844016,
0.004138053,
-0.019288879,
0.024405258,
-0.0009312272,
0.020769589,
0.005638593,
-0.010470728,
0.022964211,
0.017556978,
-0.016446447,
-0.00086760294,
-0.007641516,
-0.008262886,
0.029905034,
-0.008884254,
-0.0014038642,
0.009386638,
0.0007064767,
0.030751154,
0.00944613,
-0.017464435,
0.00026090062,
0.0063128443,
0.015996946,
-0.01351808,
-0.022170974,
-0.0125992475,
-0.04264971,
-0.028794503,
0.0021400873,
-0.015996946,
0.026679205,
0.029852152,
-0.004690014,
0.009042902,
0.013438757,
-0.00086760294,
-0.007039978,
0.002219411,
0.032892894,
-0.021946223,
-0.004293395,
-0.04090459,
0.034875985,
-0.023876434,
0.0067821764,
-0.019235997,
-0.021549605,
-0.012519924,
-0.006134366,
0.020743147,
-0.004647047,
-0.015071503,
0.008633062,
-0.005631983,
-0.01610271,
-0.013723,
0.028450767,
-0.0016938915,
0.029032474,
-0.006514459,
0.0046668774,
-0.0042173765,
-0.005860038,
0.0014641833,
-0.029693505,
0.05079361,
0.001864107,
-0.024352375,
-0.012691792,
0.011409392,
-0.0022640305,
0.0061277556,
0.016552212,
0.024339154,
-0.014952517,
-0.018112244,
-0.061660957,
0.014357589,
0.0069937063,
0.0019467358,
0.01265213,
0.0013551132,
-0.008335599,
0.0055229124,
-0.011594481,
0.002422678,
-0.014040295,
-0.009604778,
-0.02402186,
0.009075954,
-0.0125265345,
0.007403545,
0.03477022,
-0.003728214,
0.011938217,
0.019764822,
0.006583867,
-0.010272419,
0.0026573439,
0.0048354403,
0.0011725035,
-0.0026573439,
0.008051355,
0.018350216,
-0.009346976,
0.029270446,
0.012262122,
-0.01693561,
0.0048354403,
0.0016988493,
-0.0059294463,
-0.00012704186,
0.008798321,
0.016565433,
0.020729927,
0.03215254,
-0.0048651868,
-0.033368837,
0.01779495,
0.0045974692,
0.011885335,
0.0046404363,
-0.04119544,
0.0019384729,
0.00643844,
-0.024299493,
0.03151795,
0.023202183,
-0.01243399,
-0.0038571148,
-0.0074432073,
0.0019830924,
0.009499013,
-0.024127625,
-0.01760986,
-0.014357589,
0.00772084,
0.021800797,
0.019235997,
0.020016013,
0.0062103844,
-0.006735904,
-0.04907493,
0.0006007118,
0.016446447,
-0.02338727,
-0.041248325,
-0.010384794,
0.005060191,
-0.017861053,
0.02531748,
-0.00040013023,
-0.021152986,
0.0049643414,
-0.022607254,
0.0077671125,
0.0013542869,
-0.010781413,
-0.019949911,
0.0036951622,
0.027446,
0.018416319,
-0.012995866,
0.02741956,
0.0028424326,
-0.004974257,
0.0019202946,
0.016221697,
0.011006163,
0.010021227,
0.004934595,
0.017781729,
-0.0023764058,
0.009578337,
-0.0003135765,
0.041063234,
0.019328542,
-0.014516237,
-0.0029333243,
-0.008970188,
-0.003880251,
0.035034634,
-0.049048487,
-0.04547892,
-0.019540071,
-0.005298162,
0.011977878,
0.0021202564,
0.006775566,
-0.0037645705,
-0.022765901,
0.007311001,
-0.004848661,
0.02377067,
0.00014439393,
0.019791262,
-0.015309474,
0.02165537,
0.015190489,
-0.022408945,
0.021496722,
0.002465645,
0.034241397,
-0.026494116,
0.019698719,
-0.011852283,
0.009736984,
-0.0009461004,
-0.024048302,
-0.019196335,
-0.0069408235,
0.011131759,
0.022713019,
0.012810778,
-0.023704566,
0.07519887,
0.0042140717,
-0.032522716,
-0.008236445,
-0.01243399,
0.008970188,
0.013326381,
0.016446447,
-0.028159913,
-0.024590347,
0.00033092857,
-0.024524244,
0.027155146,
-0.035907194,
-0.03749367,
0.011263966,
-0.012467042,
0.017107477,
-0.016459668,
-0.013775882,
0.011290407,
-0.0030258687,
0.006045127,
0.008110848,
-0.027816176,
0.010702089,
0.02829212,
0.014978958,
-0.029640622,
-0.040402204,
0.008289327,
-0.009604778,
-0.037202816,
-0.013894868,
0.0103385225,
-0.035616342,
-0.01868073,
0.00061310607,
0.018125465,
0.007337442,
0.0061442815,
-0.0076481267,
-0.025132392,
-0.01286366,
0.006517764,
0.0035761767,
-0.015177268,
-0.008124069,
-0.0132801095
] |
During fasting, mammals maintain normal glucose homeostasis by stimulating hepatic gluconeogenesis. Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process. Although the underlying mechanism is unclear, hepatic gluconeogenesis is also regulated by the circadian clock, which coordinates glucose metabolism with changes in the external environment. Circadian control of gene expression | [
-0.03234182,
-0.020613039,
0.01430054,
-0.026328059,
-0.015755272,
0.0067216433,
-0.015222736,
-0.0041726143,
-0.029328445,
-0.021418339,
0.029042695,
0.0056338413,
-0.0018849826,
-0.0066631944,
-0.008364712,
-0.0027584715,
0.039069958,
-0.015365612,
-0.030393517,
0.014508358,
-0.0140018,
0.009780478,
0.0057961997,
-0.010670203,
-0.0013930362,
-0.0034030348,
-0.008215342,
-0.033458848,
-0.0073126284,
-0.029925926,
0.01202752,
-0.008663451,
-0.007215213,
0.029328445,
0.017171038,
-0.012111947,
-0.005896862,
-0.0067606093,
-0.009650591,
0.0014782745,
0.02091178,
0.022301568,
-0.0009822692,
0.02208076,
-0.005997524,
-0.007117798,
0.037693158,
-0.011085841,
-0.011975565,
0.038472477,
-0.010358474,
0.02317181,
0.0038349086,
-0.01350823,
-0.009553176,
0.009377829,
-0.014703189,
0.035173353,
0.0012071357,
-0.020742927,
-0.005000643,
-0.0054617412,
-0.011345615,
0.013280928,
0.0203143,
0.0036822916,
0.01765162,
0.01943107,
-0.0040784464,
-0.00053781265,
0.024522632,
0.018859567,
-0.011306648,
0.0067086546,
0.01060526,
-0.013755015,
-0.014885031,
-0.019275205,
-0.008306263,
0.017989326,
0.031068929,
-0.01665149,
-0.018197145,
0.051331274,
-0.0015789367,
-0.020041537,
-0.008767361,
0.004851273,
-0.0143265175,
0.0016674221,
-0.0020148694,
0.0045362976,
0.035926696,
0.031380657,
-0.017560698,
-0.010735147,
-0.00087105355,
0.020561084,
-0.006127411,
-0.006793081,
-0.013287422,
0.037303496,
-0.011618377,
-0.012735403,
-0.016976207,
0.008624486,
-0.002110661,
-0.004835037,
0.01320949,
-0.019054398,
-0.0048123067,
0.027458075,
-0.0053351014,
-0.041381944,
0.009611625,
0.016989198,
-0.004779835,
0.0062865224,
0.011793724,
-0.0092219645,
0.026730709,
0.012436664,
0.01745679,
-0.0063612075,
-0.0015010047,
0.015950102,
0.0021723572,
-0.017599665,
-0.0076893,
-0.017015174,
0.0018979713,
-0.020379243,
0.0018330278,
0.009325874,
-0.028756943,
0.017248971,
-0.012676954,
0.0005804318,
-0.013261445,
-0.017132072,
0.005305877,
0.022457432,
-0.030393517,
0.025873456,
-0.019015431,
0.04034285,
0.012306777,
0.0002760095,
0.0017940617,
0.0046369596,
0.01726196,
0.0044258935,
0.026912551,
-0.010826067,
0.027198302,
0.018599793,
0.0056663128,
0.018612782,
-0.023782277,
-0.025379887,
0.015521476,
-0.013586162,
-0.003053964,
0.01498894,
-0.0006092504,
0.012722415,
0.016015045,
-0.013664094,
0.0060657146,
-0.010968942,
0.0038316613,
0.00946875,
-0.0370697,
0.022704218,
-0.0181322,
0.024016075,
0.001045589,
0.022925025,
-0.02109362,
-0.012748392,
-0.021950874,
0.010001286,
0.018573817,
0.022041794,
0.003922582,
-0.013923868,
0.020431198,
-0.018443929,
0.0045752637,
-0.021405349,
-0.016729424,
0.019898662,
-0.009851916,
-0.029068671,
-0.6359259,
-0.006637217,
0.02287307,
-0.02483436,
-0.017560698,
0.026808642,
0.01509285,
-0.012527584,
-0.016248843,
0.014183641,
0.0015489004,
0.012637989,
0.015859181,
-0.025678625,
-0.014521347,
-0.026964506,
-0.016677469,
0.0068060695,
0.011611883,
-0.018976465,
-0.014573302,
-0.010897505,
-0.009585648,
0.012111947,
0.02583449,
0.018521862,
0.010624742,
-0.013936857,
0.006909979,
0.05057793,
-0.0069749225,
0.036082562,
-0.005919592,
0.0118067125,
0.051227365,
0.012663966,
-0.01911934,
0.012261316,
-0.014443415,
0.057409976,
-0.018404962,
-0.008890754,
0.023886187,
0.008994663,
-0.027665894,
0.01892451,
-0.0025165572,
0.0041628727,
0.0080335,
-0.0035881235,
0.0020928015,
0.005909851,
-0.027198302,
0.008397183,
0.009501222,
0.011046874,
0.0189375,
-0.015521476,
-0.0040070084,
0.01784645,
0.01892451,
0.031302724,
-0.023925154,
0.0024207658,
-0.0034355065,
0.0033137377,
-0.02050913,
0.004097929,
0.0063222414,
0.011287165,
0.033354938,
0.0140537545,
0.018677726,
0.0005848966,
0.031172838,
0.011722286,
0.013845935,
0.014716177,
-0.00044202112,
0.019560955,
-0.004240805,
0.004565522,
-0.032809414,
-0.000994446,
-0.00026383263,
-0.010319509,
0.0069944058,
0.009195987,
-0.00852707,
0.0050753276,
0.0027941903,
0.00018082681,
-0.0069749225,
-0.0072801565,
-0.02483436,
0.03135468,
-0.004471354,
0.0014928867,
0.03392644,
-0.021639146,
-0.0045038257,
-0.0045070727,
-0.007630851,
-0.0058449074,
0.028237397,
0.00034237356,
-0.05283796,
0.005689043,
0.04782433,
-0.027042437,
-0.001703141,
-0.00008757213,
-0.012982189,
-0.0014076484,
-0.0020327289,
-0.01784645,
0.015352623,
0.0059390753,
0.009150527,
-0.0362644,
-0.002224312,
-0.0027276233,
0.007936086,
-0.01094946,
0.016729424,
0.013040638,
-0.013287422,
-0.029847993,
-0.005117541,
0.003409529,
0.012215856,
-0.0030474698,
0.02751003,
-0.01665149,
0.040550668,
0.005997524,
0.026652778,
0.008059477,
0.017859438,
-0.046473507,
-0.02386021,
-0.001315916,
-0.008221836,
-0.008942708,
-0.0042180745,
0.007611368,
-0.013716049,
0.0293804,
0.019093364,
0.004750611,
0.00034947673,
-0.006448881,
-0.007916602,
0.01983372,
0.01863876,
0.0044421293,
-0.011137796,
-0.014703189,
-0.002937066,
0.0018736175,
0.010663709,
0.0134432865,
-0.009150527,
0.013975822,
-0.023795268,
-0.0017518486,
0.0016787873,
-0.008189364,
-0.012163902,
-0.035329215,
-0.012118441,
-0.014066744,
-0.0016276443,
0.0259384,
0.010903999,
-0.0018736175,
-0.024808384,
-0.014014789,
-0.012631494,
0.001123521,
0.014885031,
0.01099492,
-0.015105838,
-0.008793338,
0.022015817,
0.005445505,
0.013287422,
0.017093107,
0.010936471,
0.019703832,
-0.033796553,
0.03618647,
-0.004799318,
0.018677726,
0.011007909,
-0.03590072,
-0.001108097,
-0.0007545613,
-0.011813207,
0.025808513,
0.034238167,
-0.043434154,
0.015469521,
-0.020249356,
0.009137538,
-0.02761394,
-0.001056954,
-0.0143265175,
-0.004828543,
-0.009709041,
-0.012254822,
0.012689943,
0.01172878,
-0.0018038033,
0.0033023725,
0.0074100434,
-0.012105452,
-0.018028291,
-0.008585519,
0.0014677212,
0.012150913,
-0.009429784,
0.015456532,
0.008299768,
-0.0009108314,
0.029822016,
0.002529546,
0.026146218,
-0.019755786,
-0.004013503,
-0.002501945,
0.008702418,
-0.020028548,
0.018002314,
-0.0015432179,
0.01596309,
-0.006682677,
-0.016846322,
0.028808897,
0.0201974,
0.022197658,
0.0023265977,
0.036212448,
-0.0038868634,
-0.019924639,
-0.0032260641,
0.001456356,
0.009683063,
-0.017119084,
-0.000685153,
-0.0048090597,
0.030133745,
-0.027458075,
0.011267683,
0.01015715,
0.032653548,
0.018495884,
-0.009936342,
0.020574074,
0.024379758,
0.0056273467,
0.019171296,
-0.014768132,
-0.03244573,
-0.0024678498,
0.0167554,
0.029718107,
0.008416667,
-0.008364712,
-0.0048480257,
-0.040888373,
0.009234954,
-0.013975822,
-0.021366384,
0.032367796,
-0.00037931014,
0.015248713,
-0.010131173,
0.034264144,
-0.006754115,
0.0050883163,
-0.015768262,
0.03314712,
0.022496399,
-0.013573173,
-0.011858667,
-0.023288708,
-0.009890882,
0.013053626,
0.019950617,
-0.010657215,
0.006682677,
-0.0013280928,
-0.024119984,
-0.026094263,
-0.014923996,
0.020820858,
-0.0040654577,
0.01715805,
-0.01232626,
-0.009618119,
0.025795523,
-0.0050136317,
-0.016703445,
0.034368053,
0.010903999,
0.008514081,
-0.024392746,
0.016976207,
-0.024613554,
0.01795036,
0.010332497,
0.02160018,
-0.038940072,
0.010813078,
0.013923868,
-0.020236367,
0.003383552,
0.01646965,
0.005802694,
-0.0137809925,
-0.007669817,
0.007721772,
-0.009202481,
0.025808513,
0.010345486,
0.003065329,
0.019288193,
-0.005838413,
0.021561213,
-0.00852707,
-0.020976722,
0.0280036,
-0.010118184,
-0.0037374934,
-0.004789577,
-0.0148720415,
-0.011657342,
0.006315747,
-0.0046142293,
-0.00067865866,
-0.034471963,
-0.008962191,
0.01114429,
0.013177019,
-0.012319766,
0.0152097475,
0.03184825,
0.018015303,
-0.012508102,
-0.013300411,
0.014625257,
0.0072217076,
-0.0077542434,
-0.00052807113,
0.020327289,
0.0030474698,
0.0046824203,
0.013274434,
-0.020755915,
0.010722158,
-0.00848161,
0.03361471,
0.0010585777,
0.015742283,
0.024717463,
0.0064099147,
0.007890625,
-0.0014182018,
-0.02909465,
0.0028640046,
0.03610854,
-0.016742412,
-0.002454861,
0.026860597,
-0.012111947,
-0.012059992,
-0.0035881235,
-0.00036469786,
-0.019483024,
0.0110598635,
-0.021236496,
0.004445377,
-0.0011641107,
-0.01754771,
-0.0034777198,
0.016183898,
-0.020794882,
-0.0067021605,
0.021067644,
0.0045395447,
-0.026652778,
-0.017807484,
0.007591885,
-0.0046402067,
-0.03956353,
-0.017145062,
0.006435892,
0.012137924,
0.018093236,
-0.00009990123,
-0.008423161,
0.0068580243,
-0.007630851,
-0.021535236,
-0.020145446,
-0.009618119,
-0.02761394,
0.013768003,
-0.020236367,
0.03717361,
-0.023912165,
0.018365998,
-0.014846064,
-0.00095466815,
-0.012930234,
0.044291407,
-0.00955967,
-0.01736587,
-0.007962063,
0.02119753,
0.01045589,
0.024964249,
0.00764384,
0.0113326255,
-0.018197145,
-0.029354423,
-0.009722029,
-0.0056663128,
0.016885288,
0.006773598,
-0.010254565,
-0.0043317256,
-0.0079295905,
0.024405735,
-0.0052409335,
0.0065885093,
0.027198302,
0.030237654,
0.014274563,
-0.0034290121,
0.0043706917,
-0.022314556,
-0.016599536,
0.003045846,
-0.013716049,
0.036238424,
0.001479898,
-0.021639146,
0.020002572,
-0.0009733394,
-0.0066339695,
-0.01518377,
-0.00037261285,
-0.033848505,
0.05808539,
0.013365354,
-0.026678754,
-0.021028677,
-0.0015058754,
-0.025301954,
0.009709041,
-0.013832947,
0.0059812884,
-0.030341562,
-0.0041336482,
0.02406803,
-0.017378857,
0.032185957,
-0.036731996,
0.0076957946,
-0.001750225,
-0.0027617186,
-0.0065820147,
-0.0041758614,
-0.019755786,
-0.028133487,
-0.012897762,
-0.016041024,
-0.051383227,
-0.007033372,
-0.018443929,
0.032056067,
0.008260802,
0.03473174,
0.0048058126,
-0.00946875,
0.006351466,
0.014027777,
0.0073191226,
-0.03657613,
0.008884259,
-0.02189892,
0.027873714,
-0.014222608,
-0.008293274,
0.020574074,
-0.013664094,
0.028627057,
0.0073126284,
-0.008085455,
-0.023223765,
-0.0048155542,
-0.013391332,
-0.028055554,
0.030341562,
-0.012962705,
-0.00037484526,
-0.028159464,
-0.042862654,
0.03590072,
0.004068705,
0.0145992795,
-0.02779578,
0.032757457,
-0.06172222,
0.031172838,
0.0013215984,
0.005266911,
-0.003883616,
-0.03343287,
0.0018265335,
-0.0016041023,
0.014482381,
-0.00029975444,
0.01509285,
-0.015989069,
-0.014859053,
-0.006520319,
-0.005117541,
-0.018158179,
-0.011358603,
-0.012021026,
-0.0152097475,
0.000344606,
-0.026016332,
-0.024106994,
-0.02917258,
-0.01527469,
0.019755786,
-0.03135468,
0.012332754,
-0.0020132458,
-0.0051597543,
0.023041923,
-0.016833333,
0.02771785,
-0.007293145,
0.023990097,
0.01735288,
0.011176761,
0.0083387345,
-0.01528768,
-0.0023184798,
-0.0037699651,
0.03234182,
-0.002122026,
0.011598893,
-0.0053351014,
-0.006351466,
0.031380657,
-0.016820343,
-0.01208597,
0.028315328,
0.0061176694,
-0.011956083,
-0.015820216,
-0.028289352,
-0.0044193994,
-0.01646965,
0.002693528,
0.016794367,
-0.0071437755,
-0.011884645,
-0.012547067,
0.045408435,
0.005572145,
0.007871142,
-0.008364712,
-0.0006997653,
0.009247942,
0.0027195055,
-0.019067386,
0.014962963,
0.001522923,
0.022119727,
-0.0055461675,
-0.0058514015,
0.003065329,
-0.006260545,
-0.005023373,
-0.010676697,
-0.011611883,
0.0343161,
0.0035036972,
-0.013086098,
0.05216255,
0.021119598,
0.019846708,
0.0013532584,
-0.00042375576,
-0.0072022243,
-0.019275205,
0.00685153,
0.009137538,
0.020002572,
-0.031718362,
-0.0010301649,
-0.02493827,
0.0028867347,
-0.04673328,
0.00089378376,
0.015924126,
-0.027821759,
0.010819573,
-0.014820087,
0.025821501,
0.004263535,
-0.005513696,
0.012423675,
-0.014079732,
0.037693158,
-0.019379115,
0.029120626,
0.0024613554,
-0.0026123489,
-0.012047003,
0.0061533884,
-0.019340148,
-0.012728909,
0.0210027,
-0.012163902,
-0.041771602,
-0.0031107895,
0.011644354,
0.011657342,
0.01715805,
0.0022876319,
0.008046489,
0.0061728717,
0.028159464,
-0.002932195,
-0.0017242476,
0.009306391,
-0.013112076,
-0.0037959425,
0.027146347,
-0.0028980998,
-0.019846708,
-0.0120794745,
-0.024795394,
0.019275205,
-0.0045785108,
-0.004244052,
-0.023444572,
0.024301825,
-0.012540573,
0.0016852816,
-0.025808513,
-0.012891267,
-0.025081147,
0.016846322,
0.009092078,
-0.007877636,
-0.031640433,
0.0053156186,
-0.0042343107,
0.0035231803,
-0.0023753054,
0.0143265175,
0.00088404224,
-0.034653805,
-0.03865432,
0.000036835092,
-0.01509285,
0.021353394,
0.005400045,
-0.006734632,
-0.01069618,
0.011053369,
-0.026496913,
-0.024029063,
0.014949974,
0.033199072,
0.0029825263,
-0.012540573,
-0.00007706957,
0.0065333075,
-0.010624742,
0.005211709,
-0.006049479,
-0.005594875,
0.0015789367,
0.0008426408,
0.019755786,
-0.0065722736,
-0.013164029,
-0.002784449,
0.037017744,
-0.01528768,
-0.0072411904,
0.006010513,
-0.02060005,
0.041252058,
-0.01207298,
0.010176633,
-0.00013932392,
0.011033886,
0.015560442,
-0.03325103,
-0.007923096,
0.023483539,
-0.0068904962,
-0.025314942,
-0.008098444,
-0.0009895753,
-0.003692033,
0.019418081,
-0.026016332,
-0.029042695,
0.020755915,
-0.0072411904,
0.004279771,
0.027302211,
0.0049844068,
0.005341596,
0.020496141,
-0.029822016,
-0.0154175665,
-0.008553048,
-0.022535365,
0.006909979,
-0.0017063882,
-0.0085400585,
-0.0062313206,
0.021911908,
0.01163786,
-0.035173353,
0.00003498319,
-0.010397441,
-0.009851916,
-0.012034015,
0.0070073945,
-0.0031270254,
-0.0029614198,
-0.02236651,
-0.006215085,
-0.007423032,
0.00003264929,
0.0076957946,
-0.021859953,
0.013845935,
-0.006780092,
-0.0019125835,
-0.0006161506,
0.0037764595,
0.0017615901,
-0.006728138,
-0.017210005,
0.023054913,
0.19503807,
-0.011904128,
-0.010676697,
0.01578125,
-0.003065329,
-0.004734375,
0.020327289,
0.0062865224,
0.0012266188,
-0.0035718877,
-0.012137924,
0.0015245466,
-0.028471192,
-0.0023671875,
-0.0016869052,
-0.01439146,
-0.039485596,
0.015365612,
0.011663837,
-0.029822016,
0.007215213,
-0.016300797,
0.01932716,
-0.011053369,
0.0392518,
-0.01509285,
-0.015300668,
-0.0024077771,
0.022314556,
0.02641898,
-0.00951421,
0.020028548,
-0.019015431,
0.02287307,
-0.000716407,
0.016820343,
-0.00014531089,
0.0014953221,
-0.008410172,
-0.011735274,
-0.0020002571,
0.0028786168,
-0.02110661,
-0.010014274,
-0.002122026,
0.006107928,
0.0043804334,
-0.018508872,
-0.0070528546,
0.0015578301,
-0.05720216,
-0.003281266,
0.01863876,
0.04631764,
-0.001980774,
-0.016794367,
0.008682935,
0.014885031,
0.010072723,
0.017430812,
-0.019158307,
0.012839313,
-0.01972981,
0.031952158,
-0.019872684,
0.013215984,
-0.017690586,
0.007923096,
0.02623714,
0.0011835938,
-0.009644097,
0.01183269,
-0.0023395864,
-0.0011973942,
-0.0013638117,
0.001335399,
0.010072723,
0.020249356,
0.013267939,
0.021041665,
-0.008702418,
0.009306391,
-0.02200283,
-0.01823611,
0.0054292693,
-0.04229115,
0.03410828,
0.0029435602,
-0.02523701,
-0.005195473,
0.020496141,
0.011137796,
-0.02860108,
-0.010611754,
-0.00783867,
-0.029614197,
-0.0043252315,
-0.0018492637,
0.0034290121,
-0.018443929,
-0.027250256,
0.06374846,
0.011430041,
0.02435378,
-0.0043252315,
0.0023006203,
-0.023717334,
-0.0031026716,
-0.009546682,
-0.0003805278,
0.002415895,
-0.004886992,
-0.010371463,
-0.017833462,
-0.019924639,
0.016482638,
0.021561213,
-0.02040522,
0.015261702,
-0.027172323,
-0.022197658,
0.003841403,
0.014962963,
0.014144676,
-0.0013808593,
0.01430054,
-0.002651315,
-0.028834876,
-0.0030718234,
-0.035251286,
0.0016495627,
-0.012157407,
0.0061111753,
0.011676826,
0.013430298,
-0.012819829,
0.010468878,
-0.019236239,
0.0013565056,
0.03756327,
-0.0061468943,
0.002865628,
0.019664865,
0.0064618695,
0.012124935,
-0.014975951,
0.015690329,
0.0063806903,
-0.033770576,
0.01874267,
-0.0119430935,
-0.008611497,
-0.0015294173,
-0.0021090372,
0.015547453,
-0.021626156,
-0.0068969904,
-0.050863683,
0.017080117,
-0.0042862655,
-0.024717463,
0.009286908,
0.013560184,
-0.01863876,
0.012605516,
0.004019997,
-0.16126749,
0.011787229,
0.015352623,
-0.029458333,
-0.0015334764,
0.012001542,
-0.0009416795,
0.0046109823,
-0.0061761187,
0.006465117,
0.035848763,
-0.018586805,
-0.043018516,
-0.018443929,
0.013819958,
-0.014079732,
-0.0085400585,
0.031796295,
-0.0021853459,
-0.013248457,
0.010137667,
-0.027068416,
0.015079861,
-0.02356147,
-0.00715027,
0.0013094216,
0.00044851543,
0.0011486866,
-0.011274177,
-0.013202996,
-0.017989326,
0.025912423,
0.021015689,
0.021171553,
0.016820343,
-0.014404449,
-0.017171038,
-0.006793081,
-0.013138053,
0.021574201,
0.033095162,
0.017482767,
-0.01157941,
0.025587704,
-0.003916088,
0.032653548,
-0.004110918,
0.0038738747,
0.024769418,
0.0044258935,
0.023002958,
0.009955825,
0.0017372363,
0.027873714,
0.014962963,
0.01133912,
0.014118698,
0.0013881655,
0.0027227525,
-0.008143904,
0.0020570827,
-0.020833846,
0.030003857,
0.0001883359,
0.007994534,
-0.02149627,
0.0032991255,
0.0074425153,
-0.017197017,
0.014235596,
-0.025016204,
-0.02139236,
0.016989198,
-0.032575615,
0.017664608,
0.017729552,
-0.0008475115,
0.012124935,
0.0034452481,
0.021119598,
0.0044064107,
0.00017626048,
-0.05018827,
-0.02948431,
-0.012845807,
-0.0034549895,
0.017534722,
0.037693158,
0.003364069,
0.012034015,
0.023691358,
-0.012689943,
-0.008877764,
-0.011215728,
0.010897505,
0.0017924382,
0.0090206405,
-0.010592271,
0.012482124,
0.013638116,
0.027380142,
-0.0041985917,
-0.022223637,
0.007682806,
0.02909465,
0.00018031945,
-0.029588219,
0.008189364,
0.028341306,
-0.01853485,
-0.0075594136,
0.0031351433,
0.004283018,
0.007338606,
0.007864648,
0.020561084,
-0.010274048,
-0.025990354,
-0.0022795137,
-0.016586548,
0.06993107,
0.024808384,
-0.012891267,
0.007546425,
-0.024184927,
-0.01685931,
-0.14339505,
-0.050370112,
0.01567734,
0.025288966,
-0.003383552,
0.019067386,
-0.008955697,
0.006046232,
-0.010527328,
0.011527456,
-0.039615482,
-0.002889982,
0.007884131,
0.0027649659,
0.029588219,
0.013378344,
0.029847993,
0.00064862234,
-0.009286908,
0.03223791,
-0.008104938,
-0.01735288,
-0.021613168,
-0.0029971385,
0.011631365,
0.01971682,
-0.01157941,
0.00012937946,
0.018508872,
0.010137667,
0.002889982,
-0.004438882,
0.021249484,
-0.007572402,
-0.009429784,
-0.03135468,
-0.004010256,
-0.021613168,
0.03753729,
-0.015495499,
-0.00076754997,
0.008663451,
0.03756327,
-0.015391589,
0.0029338186,
0.004445377,
-0.02573058,
-0.019444058,
0.00650733,
-0.022067772,
-0.018275077,
-0.027587961,
-0.022418465,
-0.016677469,
0.033380914,
-0.010066229,
0.013949845,
0.021158565,
-0.010014274,
-0.008851787,
0.03065329,
0.007871142,
-0.0068580243,
0.008065972,
0.025717592,
-0.0056630657,
-0.033380914,
-0.043615997,
0.026250128,
-0.005880626,
-0.0012379838,
0.03057536,
-0.014521347,
-0.026704732,
-0.024094006,
0.032393776,
-0.002976032,
-0.020158436,
-0.014456403,
-0.023392618,
-0.017378857,
-0.031068929,
0.018443929,
-0.024964249,
-0.003170862,
-0.0007736384,
0.016326774,
-0.004912969,
0.012053497,
-0.009838928,
-0.016729424,
0.011761252,
0.0210027,
-0.003558899,
-0.021859953,
0.0016292679,
-0.00897518,
0.009325874,
0.005731256,
0.0046402067,
0.0040784464,
-0.0047635995,
-0.043849792,
-0.0037439878,
-0.005838413,
-0.0028315329,
0.012378215,
-0.021730065,
0.01301466,
-0.029925926,
0.0023558224,
0.002524675,
-0.037355453,
0.010170138,
-0.0062280735,
-0.012124935,
-0.026600823,
-0.0013264692,
0.02297698,
-0.007533436,
0.0035848764,
0.0329393,
-0.01157941,
0.0021236497,
-0.0063449717,
-0.0043284786,
-0.009325874,
-0.009592142,
-0.0033348443,
0.017326903,
-0.010293531,
-0.017184027,
0.01814519,
-0.03283539,
-0.002462979,
0.0051857317,
-0.005955311,
-0.028263373,
0.00003381624,
0.02405504,
0.030990997,
0.025886444,
-0.008942708,
-0.006715149,
0.0010869903,
-0.0188206,
-0.000044191962,
-0.009936342,
-0.027587961,
0.0061144223,
0.0041953446,
-0.014456403,
0.0058903676,
0.019963605,
0.010663709,
-0.013352366,
-0.012404192,
0.0019547967,
-0.009988297,
-0.016209876,
0.0018054269,
-0.03823868,
0.009735018,
-0.0022973733,
0.011767747,
-0.025094135,
0.019924639,
0.01000778,
-0.014794109,
-0.009202481,
0.016222864,
-0.026808642,
-0.01902842,
0.007845164,
0.021846965,
0.0012891268,
-0.005523437,
-0.007832176,
-0.011839184,
0.009027135,
0.008014017,
0.013131558,
0.01685931,
-0.018002314,
-0.015820216,
0.017326903,
0.033199072,
0.0017843203,
0.002912712,
0.0012639612,
0.003997267,
0.011111818,
-0.0032552886,
0.013287422,
0.010319509,
0.018755658,
0.032108024,
0.020327289,
-0.03421219,
0.024366768,
-0.0075853905,
0.019950617,
-0.005273405,
0.013677083,
0.008903742,
-0.022106739,
-0.005653324,
0.021327417,
-0.0070268773,
-0.042940587,
-0.0154825095,
0.004299254,
-0.003955054,
0.00016205412,
0.007955568,
-0.0075788964,
-0.0077737267,
0.00013759885,
-0.025055168,
0.0009506092,
-0.013884902,
0.017430812,
0.016404707,
-0.0059325807,
-0.015924126,
-0.004049222,
0.012384709,
0.0021512506,
0.0398233,
-0.0134432865,
0.0092219645,
0.008150399,
0.031094907,
-0.00069124147,
-0.04309645,
-0.032185957,
-0.012787358,
-0.02119753,
-0.019444058,
0.015313657,
-0.014339506,
0.07117798,
0.018028291,
-0.03145859,
-0.0032958782,
-0.0033997877,
0.040472735,
-0.013962834,
0.016222864,
-0.018560827,
-0.0027893195,
0.008117926,
-0.026938528,
0.008046489,
-0.07460699,
-0.008156893,
0.014859053,
0.0009644097,
-0.0005041232,
0.013612139,
-0.0032796424,
-0.0025198045,
-0.02327572,
0.0027357412,
-0.0030214924,
-0.038628343,
0.010910493,
0.047746398,
0.002138262,
0.025224023,
-0.023821244,
-0.010384452,
0.008507587,
-0.02160018,
0.00715027,
0.0034712255,
0.0024581081,
-0.015521476,
-0.007884131,
0.030887088,
0.022613296,
-0.026808642,
-0.011702803,
-0.0073451,
-0.016898276,
0.0055981223,
-0.016638502,
-0.0014303786,
0.013287422,
-0.011033886
] |
It remains controversial regarding the association between toll-like receptor 4 (TLR4) gene Asp299Gly (+896 A/G) polymorphism and myocardial infarction (MI) risk. Thus, a large-scale meta-analysis evaluating the potential association between this gene variant and MI risk is required. PubMed, Embase, Web of Science, CBMdisc, CNKI, and Google Scholar were searched until February 6, 2013. All the statistical tests were performed using Stata 11.0. Nine articles involving 10 studies were included in the final meta-analysis, covering a total of 8299 MI | [
-0.036997423,
0.010301599,
-0.0026533438,
-0.054924544,
-0.038400415,
0.021512546,
-0.030995734,
0.013705155,
-0.035282653,
-0.016277308,
-0.004186243,
-0.013432351,
0.00062314613,
-0.010535432,
0.007716457,
0.0011789032,
0.02764414,
0.009106458,
0.007839868,
-0.003012211,
-0.015692728,
0.037231255,
-0.0036406347,
0.0018089506,
0.0043453784,
0.020005628,
0.012107302,
-0.031619284,
-0.010561413,
-0.008580336,
-0.0040108687,
-0.0004493959,
-0.034918915,
-0.011944919,
0.00012249794,
-0.020707125,
0.012484032,
0.0031827136,
0.025344793,
-0.012587957,
0.023500118,
0.022084136,
0.009106458,
-0.00048917986,
-0.013887024,
-0.002760517,
0.01946002,
-0.012510013,
-0.022499837,
0.02722844,
0.010782254,
-0.003013835,
-0.013705155,
0.00047618916,
-0.020979928,
-0.0038744668,
0.006232273,
0.00787884,
-0.008340009,
-0.023811894,
0.004377855,
-0.01713469,
-0.02061619,
0.011120012,
-0.01830385,
0.012230714,
-0.01827787,
0.027877973,
0.0002888394,
0.012523004,
0.02430554,
0.03091779,
-0.008047719,
0.0030674215,
0.0288133,
-0.026319094,
-0.015315997,
-0.0033191156,
-0.006943512,
0.027696105,
0.02274666,
0.003734817,
0.021434601,
0.013887024,
0.0018414272,
-0.012354125,
0.011347349,
0.013640202,
-0.006368675,
-0.018147962,
0.0033077488,
0.01440665,
-0.0044720373,
0.011873471,
-0.0010075887,
-0.025630588,
-0.01964189,
0.028111806,
-0.008950571,
-0.0034165457,
-0.018485721,
-0.010295104,
-0.0020947452,
-0.0060633942,
-0.030813864,
-0.0020606448,
0.00040311666,
-0.008996038,
0.009301318,
-0.0043843505,
-0.021694416,
0.032450687,
-0.008314027,
-0.021668434,
0.0132959485,
-0.0013883776,
0.01808301,
-0.007248793,
-0.004377855,
-0.012263191,
0.014744408,
0.012802303,
0.010282113,
0.012958191,
0.012789313,
0.014510576,
-0.0124060875,
0.0077879056,
-0.027150497,
-0.007567064,
0.020901985,
0.012600948,
0.017641326,
0.015225063,
-0.021655444,
0.009755991,
-0.02392881,
0.0024714745,
-0.019745816,
-0.023967782,
0.003923182,
0.031203585,
-0.02236993,
0.0048325285,
-0.0022782383,
0.015614782,
0.036685646,
0.0038484854,
0.019330114,
-0.009918375,
-0.013900015,
-0.024682269,
0.016394222,
-0.0011464264,
-0.0025412994,
0.0031648516,
-0.015783662,
0.021330677,
-0.034633122,
-0.014432632,
-0.013770108,
-0.0036146534,
0.010230151,
0.02509797,
0.03226882,
0.024825167,
0.008365991,
-0.017173663,
0.019732825,
-0.03543854,
-0.018329833,
0.020979928,
-0.0062550064,
0.009002533,
0.012230714,
0.0032509146,
-0.0016985298,
0.0016197739,
-0.0050598653,
-0.024734233,
-0.010574404,
0.011068049,
0.037075367,
0.0027637647,
-0.010269123,
0.009509169,
0.01925217,
0.007716457,
-0.010438002,
-0.043077055,
-0.0077944007,
-0.0017959599,
0.0060828803,
-0.019550955,
-0.65057266,
-0.022071145,
-0.006826596,
0.0022181566,
0.008359495,
0.02935891,
-0.0008058274,
0.004150518,
-0.027955918,
0.026033299,
-0.02938489,
0.027981898,
0.015186091,
-0.021122826,
-0.027358348,
-0.025033018,
0.015536839,
-0.016433194,
0.020395348,
0.008729729,
-0.03328209,
0.016680017,
-0.0017602355,
0.0054658237,
-0.010886179,
0.007846364,
0.029073115,
-0.022317968,
-0.019771796,
0.015887586,
-0.0043746075,
0.014523567,
-0.0031193842,
0.0150431935,
0.041492194,
-0.030761901,
-0.0034750036,
0.031437416,
0.0014866196,
0.023396192,
-0.01844675,
-0.00036698638,
0.018005066,
0.00466365,
-0.0032525384,
0.061367914,
-0.008417953,
0.00719683,
0.001959967,
-0.008931085,
-0.011828003,
0.01380908,
-0.024383483,
-0.013990949,
0.018238898,
-0.0016035356,
0.032892372,
0.0059464783,
0.0016343885,
0.015484876,
-0.011087535,
0.0066966894,
-0.0035432046,
-0.0035042327,
-0.012146275,
0.004085565,
0.0059562214,
0.0130036585,
0.019927684,
0.016446186,
0.0050761034,
0.051806785,
-0.014211791,
0.011853985,
0.014627492,
0.039751444,
0.004299911,
0.03559443,
-0.011815012,
0.018108992,
0.0032817675,
0.0071838396,
-0.0015475133,
0.0051930193,
0.036062095,
0.016225344,
0.0014305973,
0.0075735594,
-0.015861606,
0.006664213,
-0.0017050252,
0.0014590144,
-0.024916101,
-0.00903501,
-0.012789313,
0.0051800287,
-0.003393812,
0.013393379,
0.00017618593,
-0.019719834,
-0.018550673,
-0.008398467,
0.024825167,
-0.009743001,
-0.002117479,
0.0010814731,
-0.035672374,
-0.026916664,
0.02313638,
-0.025240868,
-0.007313746,
-0.0026939397,
0.0030836598,
-0.0151731,
-0.007735943,
-0.022084136,
-0.010723797,
0.0033012535,
-0.020122545,
-0.031099658,
0.008216597,
0.00107173,
0.0043843505,
0.01612142,
0.004907225,
0.008099682,
-0.00505337,
-0.0032541624,
0.028839283,
-0.015290016,
0.022421893,
-0.008664776,
0.014809362,
-0.024929091,
-0.000042651,
-0.016186371,
0.02005759,
0.019563945,
0.016433194,
-0.03912789,
-0.01983675,
-0.021083854,
0.005988698,
-0.008833654,
-0.008749215,
-0.01771927,
-0.0004964871,
-0.0072812694,
0.017238617,
-0.013977959,
0.013666183,
0.00040697327,
0.015367961,
0.018849459,
-0.00028457682,
0.0039069434,
-0.0075345873,
0.004865005,
0.0103730485,
-0.01556282,
0.008314027,
-0.0024893368,
-0.013276462,
-0.00057849067,
0.0021873037,
-0.023668997,
-0.022214042,
0.012756836,
-0.0058295624,
-0.026371056,
0.010743283,
-0.020369368,
-0.003432784,
0.011503236,
-0.016952822,
0.024617316,
-0.0042739296,
-0.018407777,
-0.017329551,
-0.019304132,
-0.0072617834,
-0.013276462,
-0.005585987,
0.015393942,
0.027124515,
0.01439366,
0.019940676,
0.010386039,
0.004140775,
0.044220235,
-0.018057028,
0.01926516,
-0.025812456,
0.022681706,
0.006397904,
0.007898326,
0.0068136053,
0.008957066,
-0.020772077,
0.011808517,
-0.007956784,
-0.0005866098,
0.0065797735,
-0.03673761,
-0.0039264294,
-0.01714768,
0.01215277,
-0.0013989325,
0.01788815,
-0.006053651,
-0.003861476,
0.018044038,
0.010262628,
-0.017355531,
0.00651482,
-0.009548141,
0.030190311,
-0.017654318,
-0.0033093726,
0.0022425142,
0.015809642,
0.027072553,
0.023006473,
-0.00066049426,
-0.0035042327,
-0.00618031,
0.0073462226,
0.013315435,
-0.015848614,
-0.03777686,
-0.02042133,
0.010028795,
0.028527508,
0.022447875,
0.022110118,
0.0006897233,
-0.0031047696,
-0.017186653,
0.02277264,
0.020109555,
0.001784593,
-0.010093749,
0.0031161364,
-0.010990105,
-0.004800052,
-0.00856085,
0.02040834,
0.018355813,
-0.0026192435,
0.020005628,
0.0058360575,
0.0032850152,
-0.023227314,
0.0015824258,
-0.0075215967,
-0.029306946,
0.0019242427,
0.029099096,
0.04944248,
-0.00057077745,
0.022577781,
0.005969212,
-0.001131,
-0.00973001,
0.0066772033,
0.023668997,
-0.010886179,
-0.003725074,
0.0017017775,
0.0015142247,
-0.024825167,
-0.00094263535,
0.015082166,
-0.04770173,
0.006524563,
0.02022647,
0.027670123,
0.017927121,
0.0035561954,
0.006183558,
-0.0046019442,
-0.05120921,
0.02587741,
0.018264879,
-0.010230151,
-0.01887544,
0.011282395,
0.014159828,
-0.019693853,
0.02683872,
0.016744971,
0.013757117,
0.032398727,
0.011977396,
0.018381795,
-0.012951696,
0.023811894,
-0.031567324,
0.0000030272442,
-0.0029634961,
-0.0016449434,
0.0031729706,
-0.018810486,
-0.019330114,
0.02022647,
0.014627492,
0.0029131572,
0.003705588,
0.0042836727,
-0.009846927,
0.01751142,
-0.0002866066,
0.0015783662,
-0.013718145,
-0.01458852,
0.01944703,
-0.005774352,
0.017355531,
0.011204451,
-0.0049981596,
-0.0021028644,
-0.041700043,
-0.010918656,
-0.004728603,
0.030995734,
0.013179033,
-0.008749215,
0.009697533,
0.002887176,
0.015484876,
-0.009444215,
-0.012613938,
0.020174507,
0.015705718,
0.0200446,
-0.014159828,
0.0056996555,
-0.0077749146,
0.00952216,
0.0288133,
0.012581462,
-0.026072271,
0.0030934028,
-0.017641326,
0.004835776,
-0.014211791,
0.007352718,
0.027020589,
0.03928378,
-0.029280966,
0.018005066,
0.019174226,
-0.0020622686,
-0.021174788,
0.00058863964,
0.0074566435,
-0.00875571,
0.004796804,
0.014380669,
-0.0056282068,
0.004738346,
0.001940481,
-0.00471886,
0.012035854,
0.013835061,
0.011652629,
0.009944356,
0.0303462,
0.0065115723,
-0.021824323,
0.014042912,
0.013692164,
0.03868621,
-0.027696105,
0.014809362,
-0.011068049,
-0.010132721,
-0.022811612,
0.024539372,
-0.0011618529,
-0.01866759,
-0.0033418494,
-0.010457488,
-0.011659125,
0.0051150755,
-0.013471323,
-0.012276181,
-0.0008825535,
-0.008749215,
-0.02294152,
-0.010470479,
-0.030865828,
-0.026539935,
-0.039309762,
0.01829086,
-0.023746941,
-0.03195704,
-0.006956503,
0.022915538,
-0.0015710589,
0.0017423733,
0.0018674085,
0.015290016,
0.06282287,
-0.021174788,
-0.0049202153,
0.0021515794,
-0.0144716045,
0.014601511,
-0.020512264,
-0.024461428,
-0.01830385,
0.013068612,
0.014705436,
0.004962435,
-0.009398748,
0.006975989,
-0.005264468,
0.0054171085,
0.013140061,
0.011652629,
0.010366553,
-0.018966375,
-0.0012097559,
-0.0073657087,
-0.012178752,
-0.026293112,
-0.031151623,
-0.017784225,
-0.006930521,
0.01655011,
0.005176781,
0.023110399,
0.00006891143,
0.0010473726,
-0.0044655423,
-0.002729664,
0.011672115,
0.023201333,
0.029436853,
-0.00081394654,
0.023863858,
-0.00037855617,
-0.0210189,
-0.0043746075,
-0.0010952757,
0.009652066,
-0.010860198,
-0.001394061,
0.0245004,
0.011600667,
-0.019576937,
-0.014601511,
-0.007515101,
-0.016381232,
0.0054755667,
-0.0011805269,
-0.013159547,
-0.025136942,
0.0020898737,
0.0009296447,
-0.01080174,
-0.0056899125,
-0.012971182,
-0.014601511,
0.0057970854,
-0.020512264,
0.00063613674,
0.012256695,
-0.034529194,
-0.000955626,
0.0029781107,
-0.026098251,
0.010392535,
0.002018425,
0.0067616426,
-0.03328209,
-0.0054625757,
-0.02179834,
-0.023681987,
-0.0070864093,
-0.009704029,
0.037075367,
0.010061272,
0.032190874,
-0.022019181,
0.018018056,
0.0064596096,
0.006820101,
0.00631996,
0.0112564135,
0.0012950072,
-0.010093749,
0.02275965,
0.028761338,
0.020590208,
0.00042057288,
-0.008879121,
-0.00019364215,
-0.0052969446,
-0.012964686,
-0.0171217,
-0.0039036956,
-0.030060405,
-0.027696105,
0.0053716414,
-0.024916101,
0.022902548,
-0.049884167,
-0.0036243964,
0.030086387,
-0.004140775,
0.023032455,
0.00016796528,
0.03367181,
-0.03894602,
0.03790677,
-0.008294541,
0.024955073,
-0.013705155,
-0.044687897,
-0.011574686,
0.0037283218,
0.021668434,
-0.00670968,
0.022071145,
0.015991513,
0.0021369648,
0.0017797215,
0.0014484595,
-0.052898,
0.011308377,
-0.0052319914,
-0.002953753,
0.007060428,
-0.028267693,
0.0057970854,
-0.008736224,
-0.001453331,
0.0046214303,
-0.010710806,
0.014250763,
-0.017082728,
-0.012341134,
0.0039264294,
0.016706,
0.032216858,
0.005920497,
0.021525538,
0.0036698638,
-0.013328426,
-0.01807002,
0.0068785585,
0.014549548,
-0.0029456338,
0.006563535,
0.01827787,
-0.01905731,
-0.008658281,
0.0047740703,
0.0021775607,
-0.028761338,
-0.013380388,
0.013101089,
0.0022197803,
0.016407214,
-0.028345637,
-0.006212787,
-0.050533697,
0.023681987,
-0.025227876,
0.0028173511,
0.01597852,
-0.031593304,
0.01166562,
0.022071145,
-0.0062387683,
0.00874272,
-0.012906228,
-0.02586442,
0.002330201,
-0.025708532,
0.00393942,
-0.0037478076,
0.025149934,
0.035048824,
0.0038192563,
0.00022124732,
0.013471323,
0.0013250482,
0.020901985,
-0.009190897,
-0.02159049,
0.043856494,
-0.0009978457,
0.0063329507,
0.005102085,
-0.0032785197,
0.010853703,
0.0039459155,
0.0068136053,
-0.028943209,
-0.03265854,
-0.011087535,
0.022227032,
0.009593608,
0.010886179,
0.01984974,
-0.018005066,
-0.019797778,
-0.021551518,
-0.012730855,
0.008476411,
-0.052768093,
0.007567064,
-0.007645008,
-0.019784788,
0.025825448,
0.026994608,
0.009717019,
-0.03032022,
0.008788187,
-0.027722085,
0.017641326,
0.0015101652,
0.0015377703,
-0.01031459,
0.0024471171,
-0.006329703,
-0.021421611,
0.006261502,
0.0056249592,
-0.0027475262,
-0.042843223,
-0.003637387,
0.00992487,
-0.00015497461,
-0.015900578,
0.012503518,
0.001111514,
-0.00680711,
0.008879121,
0.004260939,
0.028683394,
-0.033386018,
0.015783662,
0.010347067,
0.0016335765,
-0.0019940676,
-0.015017212,
-0.0027280403,
0.0031469893,
-0.0024617317,
-0.0083335135,
-0.011042068,
0.018524693,
-0.02331825,
0.01477039,
-0.019589927,
-0.008801177,
-0.012367116,
0.0196289,
0.025604606,
-0.008125663,
-0.010275618,
0.020681143,
-0.014484595,
0.02214909,
-0.028631432,
0.0036698638,
0.0015629397,
-0.0075995405,
-0.04144023,
-0.012750341,
-0.02761816,
0.019576937,
0.003676359,
-0.019096281,
-0.0046084393,
0.013666183,
-0.042505465,
-0.03946565,
-0.018628618,
0.013951978,
0.022434883,
-0.0029082857,
-0.0009239613,
0.012308658,
0.00142329,
-0.011139498,
-0.019511983,
0.009866413,
-0.0030284494,
-0.011152488,
0.036711626,
0.016848896,
-0.0303462,
0.00018024552,
0.041933876,
-0.0009507545,
-0.036217984,
0.02568255,
-0.031437416,
0.023383202,
-0.016420204,
0.01769329,
-0.011009591,
-0.0021044882,
0.03632191,
-0.019667871,
-0.0020638923,
-0.009470197,
0.0086193085,
0.0068590725,
0.016783943,
-0.015588801,
0.02136965,
-0.001609219,
-0.0050273887,
-0.02974863,
0.016420204,
-0.006225778,
0.008125663,
0.02761816,
-0.0005062301,
-0.00573538,
-0.013562257,
0.008521878,
-0.0003052807,
-0.0077879056,
0.0067941193,
0.013718145,
0.00025088227,
-0.0050468743,
-0.008502392,
-0.010366553,
0.005404118,
0.0047870614,
-0.008262065,
0.010697815,
-0.024149653,
-0.026734795,
0.025370775,
0.017992076,
-0.028189749,
-0.0030463117,
0.005521034,
-0.02121376,
0.0051410566,
-0.0064108944,
-0.007118886,
-0.0028839284,
-0.009346786,
-0.0049039773,
-0.009554637,
-0.024591334,
-0.0032233095,
-0.035698354,
-0.011048563,
0.0083335135,
0.18602636,
-0.020577218,
-0.013406369,
0.003090155,
0.0024113928,
-0.00846342,
0.03678957,
0.017082728,
-0.03091779,
-0.002565657,
0.02917704,
-0.0083270185,
-0.013835061,
-0.00087037473,
0.00374456,
-0.0115292175,
-0.032944333,
-0.017979084,
-0.018031048,
-0.022850584,
0.01769329,
-0.003919934,
-0.007385195,
-0.009944356,
0.027332366,
0.0097819725,
-0.0094896825,
-0.013913006,
0.011230432,
0.004865005,
-0.02954078,
-0.003608158,
0.017420486,
0.012626929,
-0.017849177,
0.008768701,
-0.0005139433,
0.0017115205,
0.008690757,
-0.002604629,
-0.02390283,
0.014380669,
-0.009535151,
-0.017628336,
-0.008723234,
0.023240305,
0.00073519064,
-0.0017910884,
-0.030943772,
0.009762487,
-0.031229565,
0.019174226,
0.007904821,
0.013133565,
0.0010993353,
-0.020161517,
0.017004784,
-0.0050273887,
-0.0042544436,
0.0034197934,
0.016004503,
-0.0021678177,
-0.030216293,
0.00335484,
-0.04042696,
0.01961591,
-0.006086128,
0.025175914,
-0.02355208,
-0.022902548,
0.018433757,
-0.02412367,
-0.02218806,
-0.0010067768,
-0.020005628,
-0.0039848876,
0.028111806,
0.029696668,
0.010035291,
0.010308095,
0.0083465045,
-0.008931085,
-0.02938489,
-0.0041570137,
0.0006462857,
-0.025539653,
-0.009125944,
-0.0047221077,
-0.00786585,
0.014263754,
-0.0047513368,
0.022902548,
-0.006911035,
0.00086631515,
0.0032655292,
0.0026549678,
-0.0005585987,
0.004095308,
-0.011561695,
-0.028709376,
-0.018498711,
0.071604565,
-0.008729729,
-0.0012820165,
-0.02333124,
0.01748544,
-0.0041894903,
0.012438565,
0.011730573,
0.0010782254,
0.01293221,
-0.03520471,
-0.0058750296,
-0.007943793,
0.0023707969,
0.00826856,
0.01380908,
-0.023149371,
0.0054560807,
-0.0065765255,
-0.0026273625,
-0.016654037,
-0.002476346,
0.028735358,
-0.011548704,
-0.0061770626,
-0.017810205,
-0.0024812175,
-0.0161474,
-0.03502284,
-0.011016087,
-0.016173381,
0.011672115,
0.007580055,
-0.0065213153,
0.0033386017,
-0.00021739071,
-0.0069889794,
-0.019576937,
-0.0020444063,
0.006544049,
-0.019784788,
-0.004056336,
0.0030057158,
0.0013185528,
-0.006134843,
0.010717301,
0.02741031,
-0.013042631,
0.00407907,
-0.00786585,
-0.020953948,
-0.015497867,
0.010996601,
0.02139563,
0.0006073137,
-0.02683872,
-0.037802845,
-0.0051702857,
0.004075822,
-0.019486003,
0.010353562,
0.047623787,
-0.012107302,
-0.012295667,
0.0014703813,
-0.16316278,
0.023889838,
-0.0059562214,
-0.012477537,
0.019356094,
0.021031892,
0.015666746,
-0.013042631,
0.02469526,
-0.0025315564,
0.03499686,
-0.003169723,
-0.0035529477,
0.0051540476,
0.010171693,
-0.0141988,
-0.0064498666,
0.03928378,
0.00563795,
0.014718426,
0.020772077,
-0.03112564,
0.006826596,
-0.027903955,
0.028735358,
0.019187216,
-0.0030787883,
0.02138264,
-0.011678611,
-0.014276744,
-0.019758806,
0.0138740335,
0.035854243,
-0.0010311343,
0.013230995,
-0.005501548,
-0.004322645,
0.0010498083,
0.0017878406,
0.006911035,
0.03694546,
0.026994608,
0.010035291,
-0.0073916903,
-0.032788444,
0.014900296,
-0.005118323,
-0.022837594,
0.02915106,
-0.005228744,
-0.009866413,
-0.007580055,
0.02160348,
0.010002814,
0.027150497,
0.035490505,
0.006885054,
-0.00815814,
-0.011048563,
-0.012100807,
-0.005491805,
-0.008430944,
0.028995171,
-0.015095156,
0.027124515,
-0.025721522,
-0.013627211,
0.007625522,
-0.022227032,
0.014445622,
-0.032788444,
-0.0010960876,
0.010821226,
-0.011970901,
0.033334054,
0.017173663,
0.0049786735,
0.009463701,
0.026656851,
-0.0072358022,
-0.0033580877,
0.01206833,
-0.028709376,
-0.005092342,
0.012880247,
0.011399311,
0.010002814,
0.012386601,
0.007508606,
-0.015848614,
0.021759368,
-0.02764414,
0.02353909,
-0.016861888,
0.013757117,
0.014640483,
0.0038192563,
-0.0076579987,
-0.0092038885,
0.002476346,
-0.01751142,
-0.016381232,
-0.024149653,
-0.009827441,
0.030008443,
-0.025643578,
-0.005566501,
0.016731981,
0.052404355,
-0.017407496,
0.0047123646,
-0.0004672581,
-0.0065570395,
0.03923182,
-0.020330396,
0.0138740335,
-0.022811612,
-0.015290016,
-0.020356376,
-0.0067226705,
0.04713014,
-0.0059432304,
0.009379262,
0.001950224,
-0.0023967782,
-0.02704657,
-0.112758994,
-0.00058173836,
0.00815814,
0.00047821895,
-0.015627773,
0.020590208,
-0.017407496,
0.018602636,
0.0031648516,
0.051417064,
-0.024071708,
0.0030235779,
-0.005849048,
-0.012204733,
-0.0066252407,
0.00067429687,
0.0024454931,
-0.011808517,
-0.020525256,
0.046714444,
0.009535151,
-0.031151623,
0.01574469,
-0.012399592,
-0.0036990927,
-0.02064217,
-0.033412,
0.00670968,
0.008840149,
0.008859635,
0.02099292,
0.010132721,
0.005102085,
-0.0066057546,
-0.04798753,
-0.009905384,
0.00040920603,
-0.02139563,
0.029436853,
0.029436853,
-0.007131877,
0.020525256,
0.011977396,
-0.011951415,
-0.006462857,
-0.01080174,
-0.041102473,
0.024162643,
0.004981921,
-0.01714768,
0.004442808,
-0.016368242,
-0.02646199,
-0.0130166495,
0.019408058,
0.0011821508,
-0.003043064,
0.023591053,
0.003314244,
0.0045499816,
0.020694135,
-0.015264035,
-0.0029472578,
0.0057191416,
0.043051075,
-0.013302444,
0.008970057,
-0.02040834,
0.014549548,
-0.0089115985,
-0.0011553576,
0.015315997,
-0.0076904753,
-0.025500681,
-0.032580595,
0.015082166,
-0.031073678,
-0.02429255,
0.026358066,
-0.026812738,
-0.022447875,
-0.011730573,
0.0063491887,
-0.030242275,
0.024474418,
0.014809362,
-0.00014766736,
-0.0021694414,
-0.0071903346,
-0.024799185,
-0.01323749,
0.04827332,
-0.0050046546,
0.0045759627,
-0.0044103316,
0.034529194,
-0.010658843,
-0.013393379,
0.005118323,
-0.008567345,
-0.03400957,
-0.017537402,
-0.052768093,
0.024058716,
-0.009775477,
-0.0006121852,
0.008541364,
-0.009294823,
0.019369086,
-0.0028936714,
0.005404118,
0.008677766,
-0.011750059,
0.012334639,
-0.016641045,
0.0015848615,
-0.0026582154,
-0.0026906922,
0.025643578,
0.02064217,
0.041700043,
0.018225906,
-0.016706,
0.024175633,
-0.0055729966,
0.033022277,
0.009567627,
-0.011230432,
-0.010457488,
0.026604887,
-0.024058716,
-0.020291423,
0.011828003,
-0.00875571,
-0.0033077488,
0.010100245,
-0.024773203,
-0.015510857,
0.0035854243,
0.010119731,
0.033593867,
0.024097688,
-0.0258904,
-0.017433476,
-0.0016473791,
-0.018433757,
0.017758243,
-0.0039556585,
-0.035282653,
0.010301599,
0.0100807585,
-0.0025932621,
0.022136098,
-0.0070539326,
-0.009171411,
-0.037049387,
-0.032009006,
0.015121138,
0.022590771,
-0.0030787883,
0.0012941953,
-0.03515275,
0.030268256,
0.0151731,
-0.0005626583,
0.0009613094,
0.011321367,
-0.007177344,
-0.017355531,
0.01575768,
0.0044622943,
-0.02239591,
-0.02275965,
-0.0010473726,
0.0054755667,
0.01361422,
0.0034685084,
0.0036796066,
0.01751142,
-0.0052222484,
-0.00446879,
-0.00006348174,
0.016212353,
-0.007372204,
-0.010977115,
0.010340571,
0.018784506,
0.008606317,
-0.010100245,
0.012561976,
0.013679174,
0.025383765,
0.013172537,
0.021720396,
-0.014029921,
-0.0020086821,
0.011886461,
0.031723212,
0.0070734187,
0.0060568987,
0.015315997,
0.02196722,
0.003314244,
-0.0034068027,
-0.020174507,
-0.023045445,
-0.016212353,
0.008976552,
-0.033905644,
-0.03910191,
-0.0019063805,
0.000046101646,
0.027124515,
0.009483187,
-0.0033288586,
-0.0033580877,
-0.00052896375,
-0.009223375,
0.014913287,
-0.00817113,
-0.008080196,
0.02974863,
-0.0006466917,
0.02081105,
0.010762769,
0.014328707,
0.0015061055,
0.016407214,
0.05014398,
-0.013757117,
0.03304826,
-0.018602636,
0.01730357,
0.023370212,
-0.01634226,
0.0076320176,
-0.0012941953,
0.007833373,
-0.0046181823,
-0.00048471428,
-0.01577067,
0.0719683,
0.0041570137,
0.005355403,
0.0015824258,
0.0038972003,
0.019356094,
0.00729426,
0.0121137975,
-0.002583519,
-0.062095392,
0.00038160087,
-0.02064217,
0.019576937,
-0.04318098,
-0.026215168,
-0.0025429232,
0.0014070517,
0.010821226,
-0.011866976,
-0.029774612,
0.013315435,
-0.017602354,
0.0025948859,
0.0026030052,
-0.011087535,
-0.017992076,
0.048715007,
0.0070344466,
-0.003958906,
-0.012321648,
-0.003432784,
0.016848896,
-0.03834845,
0.00090853486,
0.01263992,
-0.027306383,
-0.0059919455,
-0.03250265,
0.0161474,
-0.003715331,
-0.011100526,
-0.0053391643,
-0.01983675,
-0.024383483,
0.017628336,
-0.0056899125,
-0.021538528,
-0.0037088357,
-0.0288133
] |
OBJECTIVE To examine by immunohistochemistry the relative distributions of 6 matrix metalloproteinases (MMPs 1, 2, 3, 8, 9, and 13) and the 2 proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) in osteoarthritic (OA) cartilage compared with normal, age-matched articular cartilage. METHODS Articular cartilage samples were obtained from the tibial plateau of OA knees removed at arthroplasty and from normal, nonarthritic, | [
-0.0154671855,
-0.006323084,
-0.0061003715,
-0.031889774,
-0.027629197,
0.01600944,
-0.038216084,
0.0068492005,
-0.029462537,
-0.017055219,
0.01123243,
-0.018359214,
0.0051094647,
-0.0038345193,
-0.005241801,
-0.0045639817,
0.018733628,
0.019960158,
-0.005774373,
0.008359768,
-0.02907521,
0.03183813,
0.005906709,
-0.03062451,
-0.00021988773,
0.026647972,
0.011400271,
-0.04074661,
-0.010580433,
-0.020424949,
-0.0006866953,
-0.0042347554,
-0.021896783,
0.003982994,
-0.013517649,
-0.0105933435,
0.015635027,
-0.015544651,
0.008501788,
0.0031567002,
-0.00039035117,
-0.009773506,
0.010096276,
-0.023433173,
0.012962483,
-0.006429598,
0.008488877,
0.00033084027,
-0.011716587,
0.010987124,
0.016396767,
0.01722306,
-0.012568702,
-0.00676528,
0.0048802975,
0.0094701005,
0.014331032,
0.015183147,
-0.0031276508,
-0.021535281,
-0.005706591,
-0.0052934443,
-0.034523584,
0.012213654,
0.01045778,
0.0053805923,
-0.013943707,
0.022232465,
0.010670809,
-0.021328706,
0.034549408,
0.047640998,
-0.031967238,
-0.0035892134,
0.00945719,
-0.005732413,
-0.0045994865,
-0.025950788,
0.008353313,
0.0031583142,
0.027164407,
-0.01307868,
0.014886198,
0.013440184,
0.0012297574,
-0.0059486693,
0.0043477253,
0.013453095,
0.0062682126,
-0.0071913376,
0.0132142445,
0.019856872,
0.019727763,
0.010580433,
-0.03777712,
0.02752591,
-0.017042309,
0.03571138,
0.004760872,
-0.014589249,
-0.008185472,
-0.012019992,
0.00055435917,
-0.018552877,
-0.031321697,
-0.006206886,
0.0055484334,
0.0037538265,
0.017416723,
-0.009211884,
-0.011258252,
0.051101103,
0.0042896266,
-0.043277133,
0.007798147,
-0.004773783,
0.021974249,
-0.013285254,
-0.016654983,
-0.0022190507,
0.004063687,
0.015738314,
0.025485998,
-0.037028287,
0.014563427,
0.013156146,
-0.003159928,
-0.002170635,
-0.009857426,
0.009160241,
0.018191373,
0.010709542,
0.030805264,
0.02737098,
-0.016732449,
0.011038768,
-0.02566675,
0.0020318434,
-0.02212918,
-0.034962554,
0.0056581753,
0.02690619,
-0.004137924,
-0.024117447,
-0.008437234,
-0.0024966337,
0.016216014,
0.019366259,
-0.0047027734,
-0.0028968696,
-0.0134014515,
-0.024866277,
-0.008062819,
0.006687815,
0.012910839,
-0.005403186,
-0.0052676224,
0.024737168,
-0.020011801,
-0.015957797,
0.0026757715,
-0.0024982474,
0.0206057,
0.0072365254,
-0.0032874225,
0.004973901,
0.0067846463,
0.021574013,
0.007894978,
-0.006174609,
-0.0073591787,
0.000450669,
-0.024027072,
0.009521744,
0.00491903,
0.012775276,
-0.00641346,
0.012207199,
-0.034523584,
-0.033697292,
-0.011632666,
0.010858016,
0.03661514,
-0.016551696,
0.006152015,
0.004331587,
0.036021244,
-0.0109742135,
0.0062714405,
-0.012542881,
0.023200778,
0.019637387,
0.0055774827,
-0.03842266,
-0.64740115,
-0.045446154,
0.024840456,
0.0037635097,
0.01399535,
0.04074661,
0.005128831,
-0.020412037,
-0.01083865,
0.030676154,
-0.023239512,
0.038474303,
-0.007055774,
-0.015777046,
-0.0075786626,
-0.040204354,
-0.0066103498,
-0.031502448,
0.0056484924,
0.0035859856,
-0.016267657,
-0.012646168,
0.029514179,
-0.0012160396,
-0.017713672,
0.017287614,
0.030986015,
-0.02198716,
0.015596294,
0.026957832,
-0.02553764,
0.033309966,
-0.00937327,
0.0023174956,
0.05244383,
-0.0016114342,
-0.027861591,
0.013414362,
0.015118593,
0.035453167,
-0.028791172,
-0.019805228,
-0.004480061,
-0.022826364,
-0.026622152,
0.024336932,
0.00868254,
-0.0005095747,
-0.0027451674,
-0.006804012,
0.0008170141,
0.018410858,
-0.030417938,
-0.0020431404,
0.007701316,
-0.01613855,
0.019818138,
-0.024930831,
0.024156181,
0.007940167,
0.012310485,
0.025692571,
-0.020825185,
-0.020205464,
-0.016500052,
-0.009676674,
-0.012194288,
0.0014250339,
0.006565162,
0.032612782,
0.015208969,
0.030986015,
-0.0066813594,
-0.0004462309,
0.030727798,
0.038990736,
0.004628536,
0.010012356,
-0.020011801,
-0.0031583142,
-0.00025115616,
0.0015363899,
-0.00892139,
0.0017155278,
0.023575192,
0.00944428,
-0.03997196,
0.02245195,
0.0040701423,
0.004657585,
0.014653803,
0.029617466,
-0.023639748,
-0.025021207,
-0.021083402,
0.027784126,
0.01368549,
0.020179642,
0.012052269,
-0.006616805,
-0.00807573,
0.01709395,
0.015712492,
0.010354494,
-0.007933711,
0.013336897,
-0.041185576,
0.00553875,
0.033129215,
-0.0142923,
0.0014936228,
-0.005429008,
-0.006616805,
-0.020902649,
0.002044754,
-0.0152735235,
0.02028293,
0.0006080198,
-0.0073010796,
-0.021096312,
0.023768855,
-0.019766495,
0.018075176,
-0.01967612,
0.01106459,
0.027784126,
-0.016267657,
-0.016228925,
-0.0043574083,
0.0033535906,
-0.008650263,
-0.0030517997,
0.016500052,
-0.032870997,
0.011929615,
-0.0079724435,
0.028171452,
-0.0124589605,
-0.015635027,
-0.042037692,
-0.0015339691,
-0.02290383,
0.011103322,
-0.03813862,
-0.030030612,
-0.0050933263,
-0.030185543,
0.011735953,
0.0058873426,
0.033878043,
-0.0033309965,
-0.00016209156,
-0.013175512,
-0.015777046,
0.031166766,
-0.008404956,
-0.0056033046,
-0.0058679767,
-0.0061455597,
-0.0013758113,
-0.016370945,
0.016474232,
-0.008998855,
-0.019133864,
-0.0046543577,
-0.004896436,
0.0067717354,
0.0075399303,
0.0111356,
-0.01967612,
-0.019456634,
0.0077852365,
-0.019417902,
-0.0022497138,
0.008876203,
0.0056355814,
0.006797557,
-0.020773541,
0.010451324,
-0.008824559,
0.0043993685,
-0.0064683305,
0.010703086,
-0.006629716,
0.0179848,
0.01737799,
0.013039948,
0.020786451,
-0.0043444973,
0.048234895,
-0.015660848,
0.019947248,
-0.012181377,
0.030701976,
0.012581613,
-0.01829466,
-0.020579878,
-0.010173742,
0.00008891332,
0.010941937,
0.0063037174,
-0.03677007,
0.014356853,
-0.008288759,
0.030598689,
-0.017003575,
-0.00714615,
-0.0179848,
0.033439074,
0.008450145,
0.007778781,
-0.0015969095,
-0.0051352866,
-0.0017461911,
0.006739458,
-0.0069395765,
-0.018527055,
-0.008166106,
-0.005506473,
-0.009495922,
-0.003850658,
0.008172561,
0.0169132,
-0.009631487,
-0.013801687,
0.021083402,
0.018023532,
0.01384042,
0.0021980705,
-0.0077077714,
-0.0057614623,
0.0057614623,
0.015751224,
0.0026354252,
0.028248917,
0.011510014,
0.013917885,
-0.01068372,
0.024401486,
0.0053354045,
0.004986812,
0.034239545,
-0.010283484,
0.00892139,
-0.0019172597,
-0.0040701423,
0.019004757,
0.003560164,
-0.004999723,
0.0083468575,
-0.007869157,
-0.009379725,
0.01754583,
-0.0098509705,
0.0023417035,
-0.0019721307,
0.010238295,
0.010135009,
0.042089336,
0.006629716,
0.029927326,
-0.015208969,
0.0059906296,
-0.008592164,
0.01299476,
0.0124654155,
-0.014873287,
-0.0121491,
-0.010380315,
-0.004673724,
-0.022090446,
0.011058134,
0.017210148,
-0.01660334,
0.0074366434,
0.016370945,
0.015299344,
0.013517649,
0.027629197,
0.010160831,
-0.01323361,
-0.039636277,
0.014795822,
0.016654983,
-0.011593934,
0.00067459134,
-0.007475376,
-0.023962518,
-0.04059168,
0.013453095,
0.013866242,
0.024775902,
0.026325202,
-0.009554021,
0.00992198,
0.018578699,
0.030108077,
-0.016022353,
0.0065167462,
-0.022813454,
0.0009311943,
-0.013814598,
-0.0010199563,
-0.028532956,
0.033258323,
0.018359214,
-0.02520196,
0.019004757,
-0.021625657,
-0.025176138,
0.008546975,
-0.003327769,
-0.0067459135,
0.023768855,
0.008333947,
-0.0028339294,
0.012000625,
-0.014550516,
0.02907521,
0.0083468575,
-0.019495368,
-0.03581467,
0.00090295187,
-0.00954111,
0.0036408568,
0.018191373,
-0.0007157447,
0.032638602,
-0.012491237,
0.024272379,
0.005438691,
-0.03705411,
-0.0054806513,
-0.0059518972,
-0.014679625,
-0.0063940934,
0.02690619,
0.008269393,
0.009941346,
0.012588069,
0.026828725,
-0.011671399,
0.005264395,
0.036098707,
0.0105868885,
-0.0014661872,
0.026376845,
0.017442545,
0.046530664,
-0.01799771,
0.0056775417,
0.01861743,
-0.0053676814,
-0.03578885,
0.0021867733,
0.010741819,
0.010864471,
-0.0069589424,
-0.014705447,
-0.018656163,
0.021251243,
0.0074301884,
0.02276181,
0.012407317,
-0.005664631,
0.028971924,
0.010851561,
-0.003205116,
-0.0064683305,
0.000673381,
-0.010490057,
0.0036021243,
-0.0092828935,
-0.017429633,
0.0121491,
-0.007688405,
0.0042896266,
-0.028481312,
0.008592164,
-0.004796377,
-0.009476556,
0.0055774827,
0.004179884,
-0.02152237,
0.0029888593,
-0.014021172,
0.017933156,
-0.009805783,
0.005851838,
-0.038835805,
-0.016848646,
0.0020834866,
-0.0066071223,
-0.0079724435,
0.006374727,
-0.010257662,
-0.017494187,
-0.013246521,
-0.0027096625,
0.01860452,
0.022697255,
-0.011045223,
0.010948392,
0.01877236,
-0.020721897,
-0.014085726,
0.012949572,
-0.032870997,
-0.024156181,
-0.017055219,
-0.01230403,
-0.009999446,
-0.006674904,
0.0035569363,
0.0039539444,
-0.01660334,
-0.018100997,
0.010638532,
-0.013091591,
0.0014008261,
0.020980114,
0.030676154,
-0.004338042,
-0.012355673,
-0.026570508,
-0.020721897,
-0.013943707,
-0.02783577,
-0.03769965,
0.0020512096,
-0.017739493,
0.01368549,
0.0074172774,
-0.013659668,
-0.010238295,
0.0024724258,
0.006674904,
-0.018346302,
0.0071913376,
0.0017607157,
-0.00027052243,
0.02690619,
0.023187868,
-0.003337452,
0.016358033,
-0.0069847642,
0.022426128,
0.0039184396,
-0.01030285,
0.009708951,
-0.01353056,
-0.017623296,
0.0037183217,
-0.00077465037,
-0.0073398123,
0.022684345,
0.0072688027,
-0.02475008,
-0.0046543577,
0.003924895,
0.007914345,
0.019701941,
-0.004063687,
-0.013136779,
0.0011184015,
0.027009476,
-0.014008261,
0.002548277,
0.004783466,
-0.031760667,
-0.024169091,
0.016306391,
-0.010858016,
0.015196058,
-0.0046253083,
0.02229702,
-0.010922571,
0.011716587,
-0.014072815,
-0.0072042486,
0.021135045,
-0.0028387709,
0.03152827,
0.012316941,
0.040255997,
-0.022994205,
0.015854511,
0.0053902757,
0.020024711,
0.0038280638,
-0.008617985,
0.011561656,
-0.02016673,
0.016061084,
0.03984285,
-0.011948982,
0.009592754,
-0.034807622,
0.005541978,
0.014679625,
-0.020076355,
-0.010941937,
0.0077335928,
-0.023510639,
-0.027112763,
-0.0033987786,
-0.009502378,
-0.004896436,
-0.040901538,
0.022865096,
0.037312325,
0.027267693,
-0.0031679973,
-0.015596294,
0.034497764,
-0.010670809,
-0.0015872263,
-0.0055097006,
-0.009579843,
0.0064586475,
0.010257662,
-0.00012275385,
0.017920244,
0.012497692,
0.008185472,
0.02352355,
-0.0010885452,
-0.031140946,
-0.024052894,
0.0031066707,
-0.034342833,
0.004328359,
-0.0145246945,
-0.016073994,
-0.012588069,
-0.017261792,
-0.0061165104,
-0.033284143,
0.010425503,
0.0036925,
-0.0012935047,
0.010819283,
-0.024078716,
-0.0073010796,
0.05241801,
-0.0040669143,
0.057117555,
-0.03689918,
0.01444723,
-0.004492972,
-0.015583383,
0.000101420694,
0.008185472,
0.010464235,
0.0085340645,
0.04720203,
0.03336161,
-0.016848646,
-0.016951932,
-0.0150927715,
-0.021599835,
-0.009056954,
-0.016874468,
0.013246521,
0.023123313,
-0.014189012,
-0.007397911,
0.009186062,
-0.018346302,
0.013349808,
-0.013943707,
-0.03351654,
0.0028210185,
-0.012736543,
-0.0014726426,
0.0009828376,
-0.025434354,
0.020373305,
0.017971888,
-0.03643439,
-0.018075176,
-0.029410893,
0.002770989,
0.01099358,
0.023652658,
0.038371015,
-0.009328081,
0.019598654,
0.0034439664,
-0.0051901573,
-0.012717177,
-0.02768084,
0.0029743346,
0.039558813,
0.0015154098,
0.0026902962,
0.0018785271,
0.011981259,
-0.00591962,
-0.005719502,
-0.00013021792,
-0.01983105,
-0.03276771,
-0.00020516131,
0.028971924,
0.010916115,
-0.040255997,
0.01754583,
-0.032948464,
0.010070455,
-0.007488287,
-0.011845695,
0.007462465,
-0.039171487,
-0.030030612,
0.01007691,
0.011406727,
0.018385036,
0.025498908,
-0.012162011,
0.0006148787,
0.015906155,
-0.025912056,
0.014408497,
0.0045994865,
-0.011568112,
-0.0042347554,
-0.0012192674,
-0.034781802,
-0.017313436,
0.006429598,
-0.025085762,
-0.01569958,
-0.0013903361,
-0.00036634508,
-0.013762955,
-0.002714504,
-0.014395586,
0.018539965,
-0.003161542,
0.010573978,
0.0061165104,
-0.0024401487,
0.026647972,
-0.009909069,
0.00784979,
0.008056364,
-0.004660813,
0.008114463,
0.0059163924,
-0.015622116,
0.01282692,
-0.0053579984,
-0.01660334,
-0.012323396,
0.03256114,
-0.020424949,
-0.019547012,
-0.019792316,
0.021457816,
-0.01692611,
0.014098637,
0.0061810645,
-0.03230292,
-0.0015323553,
0.024375666,
0.010322216,
-0.00045026554,
-0.023342798,
-0.016719537,
0.025111582,
-0.017455455,
-0.012562247,
-0.004105647,
-0.028558778,
0.018346302,
0.013259432,
-0.01709395,
-0.030934371,
-0.016745359,
-0.042631593,
-0.029746573,
-0.013020582,
-0.012329852,
0.007184882,
0.014847466,
-0.0085276095,
0.032612782,
-0.015247702,
0.00549679,
-0.030572869,
-0.024879187,
-0.0011046837,
-0.022503594,
0.023639748,
0.023316976,
-0.0024062577,
-0.026957832,
0.014059904,
0.015919065,
-0.0074689207,
0.030701976,
-0.0012805939,
-0.014085726,
-0.023910875,
0.004683407,
-0.017881513,
0.01444723,
0.03782876,
-0.025266513,
-0.011277619,
-0.0057453234,
0.0026886824,
0.01784278,
0.008740638,
0.0038667964,
0.008224205,
0.018591609,
0.01192316,
-0.022645613,
-0.0010417433,
-0.008940756,
0.017055219,
0.027655018,
-0.014305211,
0.010102732,
0.008398501,
-0.013608024,
-0.0048770695,
-0.019908514,
-0.009347448,
0.0013290095,
-0.005438691,
0.004237983,
-0.014034082,
-0.00082467985,
-0.006868567,
-0.017778225,
0.017907334,
0.0003007822,
0.008734183,
-0.0026467221,
-0.017068129,
0.020373305,
0.0023078127,
-0.007649672,
-0.016964843,
-0.028739529,
-0.012897929,
-0.011187242,
-0.040075246,
-0.0036957278,
-0.0216773,
0.014253567,
-0.017816959,
0.010812828,
-0.0036763616,
-0.056807693,
-0.028558778,
0.03878416,
0.17579399,
-0.0152735235,
-0.009076321,
0.0048577036,
0.015079861,
0.0036021243,
0.014008261,
-0.018268839,
-0.016951932,
0.023162046,
0.04521376,
0.013065769,
0.007365634,
-0.0010732135,
0.012897929,
-0.023020027,
-0.0051804744,
0.0027435534,
-0.009876792,
-0.0057872836,
-0.012271753,
-0.0058647487,
0.039094023,
0.024646793,
0.014008261,
0.00295981,
-0.0285846,
0.0042121615,
0.021754764,
-0.018320482,
-0.01307868,
0.0096573075,
-0.009521744,
0.005583938,
0.0072171595,
0.0003467771,
-0.016719537,
-0.00618752,
0.012904384,
0.0006386831,
0.0063166283,
-0.00025095444,
-0.01068372,
0.012084546,
0.0149120195,
0.015480096,
-0.010748274,
-0.00630049,
-0.02028293,
0.0105868885,
-0.03400715,
-0.014098637,
0.017300526,
0.022723077,
-0.0034504218,
-0.0051094647,
0.037596364,
0.0132206995,
0.01506695,
0.007811058,
-0.020902649,
0.0077594146,
-0.023123313,
0.014008261,
-0.011103322,
0.020399127,
-0.020954292,
-0.03155409,
-0.022826364,
-0.017507099,
0.021264153,
-0.004999723,
-0.008953667,
-0.0052579395,
0.012671989,
-0.018966023,
0.05197904,
0.026389755,
-0.00761094,
0.025912056,
-0.0032793533,
0.0035633917,
-0.014950752,
0.021109223,
-0.037932046,
-0.017636206,
0.022568148,
0.026493043,
-0.007255892,
-0.02181932,
0.0017655573,
-0.016629161,
-0.0058808876,
0.0048641586,
0.024466041,
0.013085136,
0.0021109222,
-0.0070493184,
-0.0242982,
0.017455455,
-0.01997307,
0.056239616,
-0.00007559902,
0.0072688027,
-0.002325565,
0.006297262,
-0.010115643,
-0.00010086593,
0.0094701005,
0.005474196,
0.026260648,
-0.044619862,
-0.0014653803,
-0.01183924,
-0.0023852775,
0.01023184,
-0.0009981693,
-0.012988305,
0.022051714,
-0.008411412,
0.0038474302,
-0.02014091,
0.01014792,
0.007275258,
-0.01629348,
0.004935168,
-0.01600944,
0.027396802,
0.012930206,
-0.03860341,
-0.008585708,
-0.012426683,
0.0042605773,
0.040178534,
0.014434319,
-0.0067136367,
0.016370945,
-0.0050223167,
0.0013419203,
0.013582204,
-0.0025402077,
0.009115052,
-0.00838559,
0.0012402475,
0.00914733,
-0.0013290095,
0.0005596042,
-0.0063585886,
-0.02122542,
-0.02229702,
-0.0032196406,
-0.008760004,
-0.004860931,
-0.018268839,
0.03354236,
0.0014637664,
-0.0065457956,
-0.014253567,
-0.0042767157,
0.01007691,
-0.028223095,
0.012316941,
0.03152827,
-0.0074818316,
-0.01753292,
0.0070880507,
-0.16112728,
0.011032312,
0.031605735,
-0.042631593,
0.037622187,
0.0017203693,
0.013065769,
-0.005909937,
0.012949572,
0.00075245986,
0.03356818,
0.014034082,
-0.01723597,
-0.006361816,
-0.0016501667,
-0.0007165516,
0.007862701,
0.029694932,
0.011877973,
0.01709395,
0.0096508525,
-0.009515289,
0.016073994,
-0.011083956,
-0.0052321176,
0.017868603,
0.0021157637,
0.02076063,
0.014034082,
-0.008753549,
-0.0105868885,
0.0018155868,
0.017920244,
0.010644987,
-0.0068621114,
-0.0021319024,
-0.0068943882,
-0.012549336,
-0.006174609,
0.0004438101,
0.006161698,
0.015983619,
0.0018882103,
0.0060680946,
-0.008727727,
0.0149120195,
0.0042476663,
-0.019585744,
0.024879187,
-0.019792316,
0.015970709,
-0.029255962,
0.023433173,
0.009366814,
0.013453095,
0.021754764,
0.00047406988,
0.010270573,
-0.006616805,
-0.014266478,
-0.0077077714,
-0.013104502,
0.029720753,
-0.0059648077,
0.0017816959,
-0.024724258,
-0.023781767,
0.024414398,
-0.013046403,
0.00055153493,
-0.0013386927,
-0.000021660959,
0.008850381,
0.019856872,
0.00596158,
0.020954292,
-0.00070162344,
0.00074116286,
0.02152237,
0.003360046,
-0.023381531,
0.0010877382,
-0.036021244,
0.0039442615,
0.007372089,
0.0071138726,
0.0024272378,
0.022322841,
-0.025770037,
0.011890884,
0.009450735,
-0.022800542,
-0.02352355,
0.008024087,
0.036021244,
0.010793461,
0.0024498317,
0.009605665,
-0.009786417,
-0.008508244,
0.017029397,
-0.013750044,
-0.006461875,
0.0142923,
0.004948079,
0.001112753,
-0.011051679,
0.00065038353,
0.020089267,
-0.012981849,
-0.0036344014,
-0.016977753,
-0.00095943676,
0.01922424,
-0.005516156,
0.02693201,
0.034136258,
-0.0018059037,
0.018733628,
-0.008398501,
0.057427414,
-0.0071590603,
-0.016358033,
0.022258287,
-0.013491827,
-0.03968792,
-0.12249804,
-0.00255796,
0.0103996815,
0.015596294,
-0.020941382,
0.01615146,
-0.0068362895,
0.030701976,
-0.03028883,
0.030831086,
-0.0195341,
-0.0037086387,
0.0010159217,
-0.020437859,
0.00944428,
-0.0065490236,
0.004418735,
-0.028687885,
-0.030469581,
0.017326348,
0.004970673,
0.0022012983,
0.02015382,
-0.011096867,
-0.0055903937,
-0.022800542,
-0.031734843,
0.03028883,
-0.0012378268,
0.02553764,
0.0023965745,
-0.0013007671,
0.006339222,
-0.00077586074,
-0.01677118,
-0.021096312,
-0.00044017893,
-0.030108077,
0.020825185,
-0.0040540034,
-0.012045814,
-0.011955437,
0.013556382,
-0.02414327,
0.014976574,
-0.0113486275,
-0.032845177,
-0.015751224,
0.014899109,
-0.020980114,
-0.008366224,
-0.015208969,
-0.02567966,
-0.008630896,
0.0077723255,
0.020941382,
0.005842155,
0.017197238,
-0.0069589424,
0.016164372,
-0.013866242,
-0.005319266,
-0.010431958,
0.020579878,
0.007598029,
-0.017829869,
-0.0074366434,
-0.024969563,
-0.005286989,
-0.016848646,
-0.003637629,
0.010173742,
-0.01767494,
-0.017920244,
-0.0054806513,
-0.00009763822,
-0.02476299,
-0.019585744,
0.02565384,
-0.015557562,
-0.019637387,
-0.015260613,
-0.0054580574,
-0.006442509,
0.034807622,
0.010051088,
-0.02538271,
0.006452192,
0.018694896,
-0.020980114,
-0.0074301884,
0.06925374,
0.012226565,
-0.020515325,
0.0054677404,
0.0065942113,
-0.010961303,
-0.012639712,
0.01368549,
-0.0046253083,
-0.03488509,
-0.016164372,
-0.06104245,
0.01192316,
0.0057356404,
0.0073527233,
0.0017155278,
-0.0051933853,
-0.00075689796,
-0.021109223,
0.032328743,
0.013904974,
-0.020321662,
0.0072817137,
-0.005729185,
0.01692611,
-0.012162011,
0.0054903347,
0.02181932,
0.020579878,
0.011400271,
0.025899144,
0.0043864576,
-0.00032196406,
-0.018165551,
0.023471907,
0.012988305,
-0.015183147,
-0.02966911,
0.017636206,
-0.009121508,
0.0075141084,
0.006868567,
-0.03310339,
0.0026321975,
0.010954848,
-0.020270018,
-0.042528305,
-0.011819874,
0.023316976,
0.02030875,
0.024943743,
-0.01323361,
-0.039610457,
0.029126855,
0.0013992123,
-0.002892028,
-0.01874654,
-0.019159686,
0.012039358,
0.0036699062,
-0.02136744,
0.054070596,
-0.007933711,
0.014227745,
-0.027939057,
-0.018152641,
0.018966023,
0.017558742,
-0.01100649,
-0.00021181846,
-0.007598029,
0.02105758,
0.0120910015,
-0.01444723,
0.013311076,
0.0026241282,
-0.008417867,
-0.007068685,
0.009566932,
0.0019947246,
-0.010277028,
-0.025111582,
0.008333947,
-0.003824836,
0.015015306,
0.007946622,
0.018385036,
-0.0059389863,
0.011019401,
-0.0015694739,
0.013020582,
0.033051748,
0.016345123,
-0.017210148,
0.04227009,
0.013072225,
-0.006842745,
-0.023613926,
0.038371015,
0.004137924,
-0.0033761845,
-0.019017667,
0.029255962,
0.013517649,
-0.014266478,
0.0076561277,
0.01736508,
0.002548277,
0.0060939165,
0.007242981,
0.041288864,
-0.015867421,
-0.00042363693,
-0.014098637,
-0.009308715,
-0.018707806,
-0.003976539,
-0.04888044,
-0.026493043,
-0.014795822,
-0.0029678792,
0.029720753,
0.00511592,
0.003673134,
-0.004279943,
-0.0059260754,
-0.0035956688,
-0.02259397,
0.0012402475,
-0.0089924,
0.02693201,
-0.004237983,
0.008088641,
-0.0038183809,
-0.009708951,
0.0076044844,
0.0041895676,
0.018578699,
0.000247525,
0.016719537,
-0.012168466,
0.013711312,
0.011781141,
-0.032819353,
-0.01784278,
0.003963628,
0.006084233,
-0.004505883,
0.024840456,
0.004183112,
0.09058245,
-0.00081822445,
-0.0039023012,
0.013582204,
-0.0066490825,
-0.0009755753,
0.010541701,
0.0002469198,
0.0012418614,
-0.042063516,
-0.0019656753,
0.0025063166,
0.014886198,
-0.02566675,
-0.01568667,
0.011703676,
-0.012646168,
0.014072815,
0.009663763,
-0.013388541,
0.0049545346,
-0.0028758894,
-0.017958978,
0.004480061,
-0.021302884,
0.00553875,
0.037105754,
-0.031140946,
0.0004861738,
-0.027706662,
-0.01061271,
0.0046446747,
-0.03658932,
-0.016048174,
0.021096312,
-0.041727833,
-0.008508244,
-0.031631555,
-0.003137334,
0.00969604,
-0.00976705,
0.020399127,
-0.018501233,
-0.017158506,
-0.02984986,
-0.027629197,
-0.0048996634,
-0.0030308196,
-0.013814598
] |
A role of WNT signaling for primary breast cancers of the basal-like subtype and as a predictor of brain metastasis has been described. However, a responsible WNT ligand has not been identified. To further clarify this question, we comparatively investigated 22 human breast cancer brain metastases as well as the highly invasive human breast cancer cell line MDA-MB-231 and the weakly motile MCF-7 as models for the basal-like and the luminal A subtype. WNT5A and B were found overexpressed in MDA-MB-231 cells as compared with MCF-7. This corresponded to | [
-0.010915478,
-0.011089164,
-0.016393257,
-0.018116754,
0.0063562286,
-0.0014846787,
-0.033721745,
0.010695031,
-0.031584077,
-0.018143475,
0.0055846632,
0.0108085945,
-0.004839819,
0.029499847,
-0.02563868,
0.010474584,
0.027602665,
0.008878011,
-0.011610221,
-0.0038210854,
0.0042218985,
-0.0023681377,
0.0003256607,
-0.010474584,
0.0035906178,
0.011610221,
0.0023230463,
-0.0439024,
0.0097264,
-0.012331684,
0.016660467,
0.027295375,
-0.011456576,
0.0188783,
0.014589598,
0.022779547,
0.022953233,
-0.016513502,
0.021617189,
-0.004853179,
0.0035605568,
0.0040047914,
0.017956428,
0.003077911,
-0.033080444,
-0.0014529476,
0.019078705,
-0.016019166,
-0.0082634315,
0.018450765,
0.003537176,
-0.010534706,
-0.019586403,
0.0076956125,
-0.024663368,
-0.0058084507,
0.02501074,
0.032519307,
0.011623581,
-0.010755152,
-0.0045325286,
0.009586114,
-0.022164967,
0.018450765,
0.0017485474,
0.023915185,
-0.013667729,
0.0086241625,
0.008343594,
-0.0039179483,
0.04358175,
0.012331684,
-0.008697646,
0.00013370876,
0.01919895,
-0.010327619,
-0.02561196,
-0.0018637811,
-0.033027004,
0.0059888163,
0.016112689,
-0.0103610195,
-0.02346093,
0.024289276,
0.024850415,
0.006312807,
-0.003837786,
-0.0026687474,
-0.011957592,
0.005113708,
0.00044632214,
0.014709842,
0.0058151307,
0.012632295,
0.0018838218,
0.006182543,
-0.010234096,
0.01825036,
0.020842284,
-0.028537896,
0.0070810323,
0.010908798,
-0.01492361,
-0.018063312,
-0.006610077,
-0.009886724,
0.00037555356,
0.0032399064,
0.03746267,
-0.007101073,
-0.04021492,
0.028885268,
-0.0053207944,
-0.024356078,
0.02287307,
-0.006680219,
0.019279113,
0.012512051,
0.0051203878,
-0.00426532,
0.013841414,
0.014856807,
0.011069123,
-0.016072607,
0.025171066,
0.0095193125,
-0.011389773,
0.009365668,
-0.035832696,
-0.00884461,
0.015992444,
-0.003991431,
0.004936682,
-0.0068806256,
-0.014108622,
0.010020329,
-0.013013067,
-0.003415262,
-0.021777514,
-0.030328196,
-0.01250537,
0.030622125,
0.00027034013,
0.0123383645,
-0.01855765,
0.0120978765,
0.028564617,
-0.0014771635,
0.008670924,
-0.0017084661,
-0.004839819,
-0.01710136,
0.01798315,
-0.019092066,
0.000075726544,
-0.0025485037,
0.012204761,
0.033133887,
-0.02284635,
-0.02650711,
0.0037309024,
0.0001703456,
0.015725236,
0.01310659,
0.042806845,
0.026694156,
0.017288407,
0.008209989,
0.004442346,
-0.03527156,
0.00072355126,
0.02224513,
-0.049032807,
0.0017285068,
-0.01189079,
-0.00549782,
0.009505952,
0.015939003,
-0.033000283,
-0.021296538,
-0.016353177,
0.014856807,
-0.001401176,
-0.014669761,
-0.03195817,
0.0075486475,
0.015017132,
-0.02625326,
-0.004505808,
-0.023046756,
0.002869154,
0.020989249,
0.0102407755,
-0.008584081,
-0.63488805,
-0.025171066,
0.00852396,
0.00067845976,
0.03751611,
0.022098165,
0.012331684,
-0.012111237,
-0.011102525,
0.01461632,
-0.027602665,
0.0062326444,
-0.01250537,
-0.023981987,
-0.0067503615,
-0.03847806,
-0.027255295,
-0.015604992,
0.019132148,
-0.008036303,
-0.026587272,
0.01310659,
-0.007248038,
0.011636942,
-0.010695031,
0.00883793,
0.041363917,
-0.03171768,
0.0032065052,
0.043367982,
-0.02712169,
0.03318733,
-0.0025685444,
-0.01736857,
0.04537205,
-0.0008792838,
-0.01736857,
0.027896596,
0.029686894,
0.020361308,
-0.004021492,
-0.0069541084,
0.0034870745,
-0.0030962816,
-0.041951776,
0.045585815,
0.0075486475,
0.008370315,
0.004632732,
-0.014108622,
0.015925642,
0.008463838,
-0.041016545,
-0.0054443786,
0.009666277,
0.00095360127,
0.026453668,
-0.029366244,
0.0062560253,
0.019132148,
0.0062126038,
0.035485324,
-0.013019747,
-0.031878006,
0.0022779547,
0.023567813,
-0.014749924,
0.009559394,
-0.0023213762,
-0.00044381706,
0.023941906,
0.047696766,
-0.0015823769,
0.0006137451,
0.03965378,
0.031904727,
-0.011530058,
0.015939003,
0.008203309,
0.0068939864,
0.009232063,
-0.010982281,
-0.038317736,
0.0046160314,
0.0093122255,
-0.002281295,
-0.017448733,
-0.0007039281,
-0.002658727,
0.0092253825,
0.016767351,
0.0027205192,
-0.008443797,
-0.041844893,
-0.0014278969,
0.023046756,
0.015498108,
0.014509436,
0.0077290135,
-0.028137082,
-0.0311031,
0.015364504,
0.015458027,
-0.020895725,
0.012565493,
-0.012605574,
-0.026680795,
0.004722915,
0.011690384,
-0.024022069,
-0.010427822,
0.0046895137,
0.011142606,
-0.011022362,
0.001403681,
-0.018090034,
0.00823003,
-0.000148948,
-0.0062326444,
-0.008644204,
0.022512339,
0.008116466,
-0.0004233589,
0.0031781143,
0.030729009,
0.002501742,
0.008704325,
-0.02189776,
-0.00026887882,
-0.0034403128,
-0.0047997376,
-0.018090034,
0.005337495,
-0.026600633,
0.0067036,
0.0042118784,
0.011042402,
-0.016513502,
-0.01370781,
-0.019359276,
-0.033668306,
0.006192563,
0.014482715,
0.0028274027,
-0.03107638,
-0.026467029,
-0.033748467,
0.016660467,
-0.011329652,
-0.0036975013,
-0.01434911,
-0.016927676,
0.0048064175,
0.018677892,
0.03356142,
-0.009385708,
0.01706128,
0.0005152119,
0.004752976,
-0.01159018,
-0.018383963,
-0.00018276663,
-0.000094305906,
-0.020802202,
0.012692416,
-0.008330233,
0.010147253,
0.00730816,
0.020534994,
-0.0439024,
-0.015738597,
-0.014830086,
-0.0073482413,
0.013153352,
-0.0026754278,
0.003112982,
-0.0015949024,
-0.0027338797,
0.0011139265,
-0.002496732,
0.000297061,
-0.015511469,
0.0058117905,
-0.00912518,
0.017261686,
0.035565488,
0.027549224,
-0.00945919,
0.00039455044,
0.009419109,
-0.010988961,
0.015511469,
-0.0039713904,
-0.011403134,
0.0032515966,
-0.022913152,
0.029713614,
0.01647342,
-0.009185301,
0.027241934,
0.018130114,
0.008296832,
0.0018804817,
0.022378733,
0.007648851,
-0.023340685,
-0.0044690664,
0.0050836466,
0.018170197,
-0.02136334,
0.008697646,
0.013447281,
-0.0016733949,
0.0029643474,
0.0073950025,
0.00059620955,
-0.0050970074,
-0.015297702,
0.006369589,
-0.027549224,
-0.010027009,
0.0016834153,
0.0017151462,
-0.00005281548,
-0.003325079,
0.023901824,
0.020909086,
-0.001950624,
0.013975019,
0.00152309,
0.010761833,
0.01826372,
0.01065495,
0.006763722,
0.008330233,
-0.010695031,
0.008390355,
-0.001646674,
0.009986928,
-0.012017714,
-0.008610803,
0.012939584,
-0.003781004,
0.005377576,
0.015618352,
-0.0142823085,
0.027629387,
0.016032526,
-0.011356372,
0.00335347,
0.011129245,
0.010641589,
0.0022311932,
0.027575945,
0.0035772573,
-0.04577286,
0.013988379,
0.008016263,
0.034176,
0.007401683,
0.027869875,
0.0040682536,
0.014482715,
-0.002959337,
0.0019973856,
0.005577983,
0.0075486475,
0.0061691822,
0.008256751,
-0.008490559,
-0.009352307,
-0.011510017,
0.03901248,
-0.052346196,
-0.0010220736,
0.0067036,
0.0016116028,
0.004362183,
-0.00022462237,
0.022752827,
-0.008350274,
-0.030996216,
0.03019459,
0.021162935,
-0.031664237,
-0.01218472,
-0.016112689,
0.008898052,
-0.0018871619,
-0.020000577,
0.0012909523,
0.007101073,
-0.0076622115,
0.0062126038,
0.003844466,
-0.0025134324,
0.00018360165,
-0.013787973,
0.015017132,
-0.01985361,
0.011229448,
0.007976182,
-0.0063796095,
-0.006179203,
0.03909264,
0.005026865,
-0.008964854,
-0.005123728,
-0.015097295,
-0.010153933,
-0.00853064,
-0.011817308,
-0.00058368413,
-0.017154803,
-0.0013352088,
0.010554747,
0.022512339,
0.014148704,
0.02837757,
0.0007465145,
-0.005354196,
-0.018864939,
-0.022752827,
0.0023664676,
0.009111819,
0.022191688,
-0.0014437623,
0.01704792,
0.018370602,
0.007582049,
-0.03265291,
-0.0009636216,
0.01675399,
-0.0038511464,
0.0069941897,
-0.0076087695,
0.003563897,
0.015992444,
0.02439616,
0.02562532,
-0.013594246,
-0.024783613,
0.0021393402,
-0.013480682,
-0.004789717,
-0.021403423,
0.028297408,
0.03778332,
0.015711876,
0.0026687474,
0.008356954,
0.034550093,
0.008483878,
-0.008911412,
0.005461079,
0.01889166,
-0.003537176,
0.0053842566,
0.015591632,
-0.028938709,
-0.014055181,
0.010173974,
-0.0067603816,
0.003901248,
0.026707517,
0.011850709,
0.025451634,
0.009626196,
-0.0031831244,
-0.02923264,
0.0134072,
0.009011616,
0.013948298,
-0.033748467,
0.02684112,
-0.01798315,
-0.0067503615,
-0.031156542,
0.0060789995,
0.0057783895,
0.009980247,
-0.0012074496,
0.0070810323,
-0.009532672,
-0.012091197,
-0.019733367,
0.015979085,
-0.005855212,
0.025331391,
-0.00079995627,
-0.026667435,
0.006279406,
-0.0046761534,
-0.016981117,
-0.000853398,
-0.030248033,
-0.029205918,
-0.0014838437,
0.013313677,
0.033427816,
0.018464126,
-0.008851291,
0.0034937547,
0.047723487,
-0.012465289,
-0.01738193,
0.014790005,
-0.016914316,
-0.0008776138,
-0.014536157,
-0.0024633307,
-0.015311062,
-0.020241065,
-0.0015923972,
-0.0029109055,
-0.005100347,
0.020762121,
-0.0038578266,
0.012852741,
0.01861109,
0.013347078,
0.021817597,
0.00073273655,
0.003261617,
0.008757767,
-0.008971535,
-0.026907923,
-0.009205342,
-0.00945919,
-0.012311644,
0.0127993,
0.0058418517,
-0.024984019,
0.0047396156,
-0.01065495,
-0.026266621,
0.010227416,
0.01617949,
0.008176588,
0.025384832,
-0.0028541237,
0.0056514656,
0.0083836755,
-0.0026904582,
0.012365086,
-0.009953527,
0.03388207,
-0.013761251,
-0.029125756,
0.009018295,
-0.006002177,
-0.016967757,
-0.010207375,
-0.0164467,
0.010628229,
0.020588435,
0.008684285,
-0.024636649,
-0.0039179483,
-0.006058959,
-0.0071678753,
-0.006646818,
-0.023661336,
-0.017395291,
-0.011550099,
0.03382863,
-0.014830086,
-0.041898336,
0.0062560253,
-0.029072315,
-0.024462963,
0.022271851,
-0.01855765,
0.0064263707,
-0.002501742,
0.00881789,
-0.028217245,
-0.031450473,
-0.007762415,
-0.014001739,
-0.010320938,
-0.003203165,
0.027816433,
0.01891838,
0.021149574,
-0.0016951056,
0.019653205,
0.020588435,
0.006346208,
-0.0024148992,
-0.01829044,
0.014469354,
-0.009238743,
0.026707517,
0.011416495,
0.004632732,
0.0421121,
0.019172229,
0.016981117,
0.021496946,
-0.014736564,
-0.008490559,
0.0064998535,
-0.034603536,
-0.025665402,
-0.009539353,
-0.020855645,
0.0019005224,
-0.060763273,
-0.002658727,
0.012271563,
0.0044056047,
-0.000016243892,
0.003777664,
0.008711006,
-0.009632876,
0.0056247446,
0.0008300172,
-0.01763578,
-0.010167293,
-0.022178328,
0.0035004348,
-0.023621256,
0.0100002885,
-0.020174261,
-0.0024182394,
0.019907054,
-0.03658088,
-0.0013510743,
0.000019936278,
-0.02105605,
-0.0061959033,
-0.016767351,
-0.027950037,
-0.025478356,
-0.0063929697,
-0.030007545,
-0.023233803,
0.01736857,
0.011917511,
-0.018731335,
0.023968626,
-0.0076087695,
-0.02406215,
0.047349393,
-0.022939872,
0.031878006,
-0.0124252075,
0.04366191,
0.006914027,
-0.0036039783,
-0.010100491,
-0.0065599754,
-0.022325292,
0.0016642096,
0.018731335,
0.018477486,
-0.011002321,
-0.0025835747,
-0.0068739457,
0.031744402,
-0.021710712,
-0.022138245,
0.0183038,
0.0028424333,
-0.0036641003,
-0.0021994621,
-0.009178621,
-0.013046468,
0.021884399,
-0.017796105,
-0.009960207,
-0.013387159,
-0.010621549,
0.0079026995,
0.0005674011,
0.00028537062,
0.0079026995,
-0.012659015,
0.0087444065,
-0.0010095481,
-0.007501886,
-0.0034937547,
0.0092253825,
-0.0018103394,
0.033401094,
-0.008610803,
0.0065933764,
0.024169033,
0.029740335,
-0.0055412417,
0.0014028461,
0.0037910244,
0.043955844,
0.00095360127,
0.00823003,
0.0028190524,
-0.002533473,
0.019426078,
0.00334846,
0.014870168,
-0.010541386,
-0.040321805,
-0.0038812074,
0.030729009,
0.013480682,
-0.0012107898,
-0.0059687756,
-0.040642455,
0.015337783,
-0.026133018,
-0.028511176,
-0.0035438563,
-0.04379552,
-0.006914027,
-0.0019038625,
0.010307578,
0.022191688,
0.0051638093,
-0.008590762,
0.0076956125,
0.032439142,
-0.012471969,
0.010300898,
0.0014412573,
-0.0046527726,
-0.03869183,
-0.0038878876,
0.013260235,
-0.029312802,
-0.005427678,
-0.029072315,
0.00048849103,
-0.014576239,
0.0050469055,
0.003750943,
0.0117371455,
-0.017715942,
0.015725236,
0.014790005,
0.017168162,
-0.00855068,
-0.0122181205,
0.005367556,
0.00065090385,
0.016941035,
0.008503919,
0.022084804,
-0.014055181,
0.00457261,
-0.0021710712,
-0.0009477561,
-0.017809464,
-0.017822824,
-0.013587566,
0.01159686,
-0.002929276,
-0.014602959,
-0.015952364,
-0.0036407195,
-0.020361308,
0.013547485,
-0.0021994621,
-0.016820792,
0.0034302925,
-0.0016383238,
-0.0065699955,
-0.0032482566,
-0.040589012,
-0.029499847,
0.0030929414,
-0.022712745,
-0.02469009,
-0.000065445274,
-0.028537896,
0.02650711,
-0.0011598531,
-0.018758055,
-0.028404292,
-0.004355503,
-0.04304733,
-0.014776645,
-0.012111237,
0.0013585896,
-0.017168162,
0.010247456,
-0.011383094,
-0.0025785647,
0.008690965,
-0.0011356373,
-0.009986928,
-0.00014905239,
0.0071077533,
-0.023527732,
0.020267785,
0.01891838,
-0.02896543,
-0.03815741,
0.02561196,
-0.025050823,
-0.038798712,
0.02411559,
-0.025358113,
0.016032526,
-0.008958174,
0.009599475,
0.011783906,
0.024262557,
0.025772285,
-0.021390062,
-0.002256244,
-0.00074526196,
0.00823671,
0.006827184,
-0.009065057,
-0.00396471,
0.015925642,
-0.0054076375,
0.0014796685,
-0.0377566,
0.02315364,
0.017208245,
0.001860441,
0.012832701,
0.03171768,
0.038344458,
0.0219512,
0.00426866,
0.004853179,
-0.006419691,
-0.017796105,
-0.0065332544,
0.0038912278,
0.000670527,
-0.026680795,
-0.0002578147,
0.0131132705,
-0.03751611,
0.021577109,
0.011677023,
-0.0029810478,
-0.035805974,
0.020922447,
-0.0045358688,
-0.023394128,
0.00050769665,
0.015351144,
-0.028324129,
-0.016206212,
-0.021162935,
0.002378158,
-0.024489684,
-0.012431888,
0.012832701,
0.00097030186,
0.021884399,
0.006025558,
-0.0024750212,
-0.0023197061,
0.003199825,
0.19923085,
-0.0037676436,
-0.0061023803,
0.028751664,
0.01950624,
-0.011516698,
0.022311931,
0.0023798281,
0.021603828,
-0.0103677,
0.02436944,
0.004906621,
-0.010227416,
0.008196629,
0.02315364,
0.020722039,
-0.01493697,
-0.015164098,
-0.009325586,
0.00076655514,
0.012178039,
-0.016032526,
0.00976648,
-0.0122181205,
0.018450765,
0.011944232,
-0.03414928,
-0.020374669,
0.023407487,
0.024302637,
-0.034229442,
0.019305833,
-0.0017852886,
0.02012082,
-0.01923903,
-0.010648269,
-0.035164673,
-0.011102525,
-0.008711006,
0.011296251,
0.01553819,
0.003627359,
-0.010521345,
0.03388207,
-0.0045458893,
0.011229448,
0.010895438,
-0.02375486,
0.021790875,
0.015404586,
-0.0348173,
0.026266621,
0.01950624,
0.013600926,
-0.014977051,
-0.0065332544,
0.008203309,
0.0020892385,
-0.021617189,
0.0366076,
-0.025732204,
-0.02193784,
-0.037596274,
0.036180068,
-0.0036173386,
0.031557355,
0.004395584,
0.0057149273,
0.023380768,
-0.008664244,
-0.0062293042,
-0.0073014796,
-0.0079026995,
0.019372636,
-0.007127794,
-0.03193145,
0.0328934,
0.019132148,
0.011443215,
0.031744402,
0.0029710275,
0.011670343,
-0.012325005,
-0.01794307,
-0.012952945,
-0.00883793,
0.0095527135,
0.026654074,
0.0038010448,
-0.009906765,
0.0020207663,
-0.0051704897,
0.005547922,
0.0013569195,
0.0039446694,
-0.003720882,
-0.009352307,
0.009659597,
-0.011082483,
-0.03449665,
-0.013333717,
0.07540631,
0.009332266,
0.009960207,
-0.02256578,
-0.0067036,
0.01402846,
0.027549224,
-0.006740341,
0.005911994,
-0.0038043847,
-0.029419685,
-0.009178621,
-0.019051986,
-0.014696483,
0.013253555,
0.01128289,
-0.001008713,
0.018009871,
-0.036554158,
-0.012325005,
-0.030835891,
-0.00082709466,
0.03195817,
-0.011042402,
0.019292474,
-0.015671793,
-0.0039747306,
-0.00025092575,
-0.0087444065,
0.008330233,
-0.022151606,
-0.03326749,
0.0034085817,
-0.002989398,
0.005086987,
0.009385708,
-0.0052907337,
0.0033033683,
0.020775482,
-0.005952075,
-0.008971535,
0.013347078,
0.004853179,
0.0124252075,
-0.016406618,
0.012151319,
0.0021259796,
0.000019675334,
-0.027014807,
-0.023367407,
-0.008610803,
0.01495033,
-0.007254718,
0.03687481,
-0.0052573327,
-0.030435078,
-0.023260523,
0.000163561,
0.007415043,
-0.02406215,
0.011697064,
0.017782744,
-0.019132148,
0.011710424,
0.0008425426,
-0.16834152,
0.013774612,
0.02984722,
-0.03257275,
0.02501074,
0.001860441,
-0.011757186,
-0.017849546,
-0.01279262,
0.017275047,
0.027629387,
-0.0060422583,
-0.021149574,
0.0071478346,
0.0038244254,
0.011242809,
0.008163228,
0.045265164,
-0.0046126912,
-0.0052573327,
0.024275916,
-0.03318733,
0.0054644193,
-0.006369589,
-0.002353107,
0.000975312,
-0.0038344457,
-0.0032465865,
-0.011349692,
-0.017796105,
0.013761251,
0.016513502,
0.038023807,
-0.013073189,
0.04387568,
0.016914316,
-0.0049266615,
-0.019439438,
-0.021256458,
-0.0045091477,
0.027950037,
0.033053726,
0.010474584,
0.0041317157,
-0.007588729,
0.023287244,
0.0052005504,
-0.0021276497,
0.003867847,
-0.01953296,
0.027228573,
-0.0063194875,
0.02163055,
0.022792907,
0.009198662,
0.023113558,
0.016259653,
0.002621986,
0.00244162,
-0.021122852,
-0.01099564,
-0.015898922,
0.012298283,
0.022338653,
-0.015912281,
-0.03262619,
-0.024850415,
-0.006503193,
-0.04355503,
0.01678071,
-0.025438275,
-0.030729009,
0.01006041,
-0.033027004,
0.015885562,
0.021737434,
0.02283299,
0.010688351,
0.0043421425,
0.0077290135,
-0.024436241,
-0.00011638194,
-0.027950037,
-0.016887594,
-0.029179197,
0.0048966007,
0.013119951,
0.02593261,
-0.0044724066,
-0.014856807,
0.004061573,
-0.017128082,
0.01495033,
-0.03930641,
0.018624451,
0.029312802,
-0.008330233,
-0.022458896,
-0.004966743,
-0.0072413576,
0.02407551,
-0.016206212,
-0.02470345,
0.03169096,
0.023086837,
0.002378158,
-0.025157705,
0.024262557,
0.034630258,
-0.008731047,
-0.015377864,
-0.002503412,
0.011129245,
-0.00852396,
-0.004001451,
0.02955329,
-0.009946846,
0.026426947,
0.021296538,
-0.015671793,
0.058572162,
-0.0041016545,
0.011222769,
-0.0057115876,
0.0074885255,
-0.006860585,
-0.13638335,
-0.034897465,
0.00075486477,
0.020334587,
-0.03684809,
0.025678763,
-0.01066831,
0.016206212,
-0.026239902,
0.033107165,
-0.009358987,
-0.023995347,
-0.0056214044,
-0.0023698078,
0.013654368,
-0.02042811,
0.036767926,
0.0005289899,
-0.0068071433,
0.043127496,
0.012765898,
0.008350274,
-0.015511469,
-0.026092935,
0.014228866,
-0.025211148,
-0.03350798,
0.0012533761,
-0.00023547772,
0.010855356,
-0.007555328,
-0.010113852,
0.013400519,
0.012765898,
-0.009559394,
-0.012725817,
-0.008069704,
-0.007889339,
0.039814107,
-0.012745858,
0.006823844,
0.010534706,
0.0019339235,
0.0076956125,
-0.030568684,
-0.0023447569,
-0.024356078,
0.009118499,
0.021109493,
-0.030301474,
-0.020922447,
-0.0133537585,
-0.020321228,
-0.006179203,
0.018116754,
-0.01738193,
0.012044435,
0.025344752,
-0.0145227965,
0.0054944805,
-0.016099328,
0.003199825,
-0.01803659,
0.0009794871,
0.022979954,
-0.002618646,
-0.010207375,
-0.018383963,
0.017862907,
-0.008410396,
0.0014521127,
0.0010078781,
-0.015311062,
-0.013440601,
-0.03567237,
0.008116466,
0.015284342,
-0.010280857,
0.0014253918,
-0.013480682,
-0.022993315,
-0.0095193125,
0.025558518,
-0.015965724,
0.024503045,
-0.013280275,
0.0040715938,
-0.011296251,
0.009078418,
-0.027843153,
-0.0052840533,
0.048631996,
-0.0017468773,
-0.014749924,
-0.0027806412,
-0.008944813,
0.0032733073,
-0.017208245,
0.01525762,
0.02741562,
-0.015952364,
-0.0047763567,
-0.05186522,
0.017315129,
-0.013153352,
-0.011630261,
0.030862613,
-0.002503412,
-0.008423757,
-0.0055913436,
-0.0070877126,
0.03420272,
-0.0066033965,
0.027469061,
-0.023407487,
0.007956141,
-0.0024650008,
-0.012525411,
0.014188785,
-0.031129822,
0.0051404284,
0.033294212,
0.008791168,
-0.021523666,
0.018677892,
-0.0073282006,
-0.019519601,
-0.014536157,
-0.012291604,
0.008904732,
-0.009078418,
-0.00853064,
0.007401683,
-0.034229442,
-0.023407487,
-0.0225257,
-0.020334587,
-0.025211148,
-0.023981987,
0.020641876,
0.013286956,
0.049780995,
-0.012692416,
-0.025865808,
0.017542256,
0.00669692,
-0.0073215202,
0.0022078124,
-0.034229442,
-0.0012174699,
0.0044724066,
-0.001736857,
0.020307867,
0.012345045,
0.014790005,
-0.025171066,
-0.019599764,
0.011015682,
-0.013894856,
-0.021176295,
-0.018651173,
0.012311644,
0.017502174,
0.027602665,
0.0057182675,
0.02678768,
0.011610221,
-0.0012842722,
-0.0050769667,
0.008109786,
0.005825151,
-0.023273883,
-0.013948298,
-0.008443797,
0.011302931,
0.018530928,
0.013587566,
0.01616613,
-0.0005243972,
0.0005068616,
-0.017729301,
0.023915185,
0.024636649,
-0.0036908211,
-0.03473714,
0.009532672,
0.0042118784,
0.0038210854,
-0.024516404,
0.022913152,
0.01434911,
-0.009051697,
0.02038803,
0.013240194,
0.020334587,
0.009358987,
-0.018717974,
0.02105605,
-0.012565493,
0.013868135,
-0.004215218,
0.021550387,
-0.002929276,
-0.010107172,
0.006643478,
-0.019679926,
-0.026360145,
0.025825728,
-0.0322521,
-0.029152477,
-0.0037275623,
-0.013166712,
-0.0017585676,
0.012378446,
0.0108085945,
0.0036039783,
0.0008012088,
0.012832701,
0.015124016,
-0.00213266,
-0.016072607,
0.018798137,
0.020267785,
0.0056882068,
-0.013600926,
-0.0036641003,
-0.0056113843,
0.0059220144,
0.01707464,
-0.040428687,
0.025064182,
-0.024222475,
0.007688932,
-0.0025952652,
-0.043394703,
0.001952294,
0.008871331,
-0.006005517,
-0.0069674687,
0.019559681,
-0.03297356,
0.0842242,
0.015671793,
-0.019666566,
0.0076354905,
-0.022899792,
0.021416783,
0.016967757,
0.012131278,
-0.010220735,
-0.02189776,
0.0056581455,
-0.030755728,
0.011009001,
-0.016941035,
-0.019038625,
0.01740865,
-0.00025823223,
0.0050368854,
0.0039079282,
-0.023073478,
0.0063228277,
-0.0036674403,
0.008951494,
0.01890502,
-0.028404292,
0.010514665,
0.01307987,
0.0068205036,
-0.011416495,
-0.017168162,
-0.008557361,
-0.017715942,
-0.042780124,
0.0011373073,
0.010761833,
-0.01217136,
-0.012585533,
-0.045612536,
0.019599764,
0.022899792,
0.019038625,
0.0020975887,
-0.011463256,
-0.018971823,
0.013921577,
-0.018143475,
-0.012719138,
-0.0280302,
-0.016419979
] |
Retinoids (e.g., vitamin A and its derivatives) can regulate immune responses. The aim of this study was to determine whether all-trans retinaldehyde (retinal), a vitamin A derivative, can inhibit inflammatory responses and joint destruction in DBA/1J mice with collagen-induced arthritis (CIA). The arthritis score and incidence of arthritis were lower in mice treated with retinal compared to those treated with cottonseed oil. Histopathologic evidence of joint damage was lower in mice treated with retinal, corresponding with a reduction in the infiltration of immune cells in mice treated with retinal type II collagen (CII)-stimulated | [
-0.028323531,
-0.023259059,
-0.010128945,
-0.005811415,
-0.026916733,
0.021825464,
-0.017497886,
-0.015233612,
-0.018194586,
-0.022790127,
0.008313506,
0.010142343,
0.010483994,
-0.012433414,
-0.023647603,
0.0073488443,
0.0528956,
0.008809235,
0.012895647,
0.01572934,
-0.014268951,
0.021745076,
0.0010793825,
-0.011428558,
-0.0032808536,
-0.009753799,
0.01823478,
-0.049653266,
-0.009927974,
-0.014577106,
0.023835177,
-0.0056472886,
0.009023604,
-0.0075699124,
0.0022793475,
0.0067827757,
-0.0002315355,
-0.022173814,
0.0070004943,
-0.0034047859,
0.01761847,
-0.00059998257,
0.0001269677,
-0.010175838,
-0.005041026,
0.0015985578,
0.009680109,
-0.01413497,
-0.01127448,
0.019454006,
0.017631868,
0.024170129,
-0.008809235,
-0.029047027,
-0.016184876,
0.014670893,
0.01231953,
0.014443126,
-0.002394906,
-0.021168958,
0.0015357544,
0.016506428,
-0.026916733,
0.010075353,
-0.010410304,
0.0062100077,
0.0048902975,
0.0135655515,
0.021316338,
0.010088751,
0.055253662,
0.046330545,
0.0016948566,
-0.007415835,
0.013960795,
-0.010611275,
-0.02792159,
0.0037782572,
0.027224889,
-0.0053424826,
0.026233431,
0.00640428,
-0.0137866195,
0.010631373,
0.013666037,
0.00082146947,
-0.004836705,
0.025107993,
-0.0058784056,
-0.029824115,
-0.008293409,
0.0071277763,
0.005674085,
0.017792644,
-0.03416509,
0.012902346,
0.0313247,
0.026434403,
-0.011328072,
-0.007060786,
-0.0067325328,
-0.017926624,
0.007469427,
-0.02115556,
-0.017283518,
-0.0045218505,
-0.015367593,
0.002408304,
0.025603723,
-0.01092613,
-0.028725473,
0.026782753,
0.013679435,
-0.053270746,
0.036683932,
0.007958457,
0.028859455,
0.0133109875,
0.0136325415,
-0.010624674,
0.0021001482,
0.021249348,
0.029207805,
-0.027211491,
0.028725473,
0.01705575,
-0.011475451,
-0.0021453667,
-0.025081197,
-0.0040261215,
0.0134047745,
0.0064344257,
0.0014352688,
0.010329916,
-0.014429728,
0.021584298,
-0.01816779,
-0.0032038148,
-0.009499235,
-0.017779246,
-0.0006171488,
0.008380496,
0.0024669205,
-0.009345158,
0.018355364,
0.033736352,
0.01572934,
0.018985072,
-0.016251866,
0.014912058,
-0.01315691,
-0.032423344,
0.0013615794,
0.0011840549,
0.012694676,
-0.007844573,
-0.005798017,
0.02518838,
-0.021798668,
0.007898166,
0.026179839,
-0.037514612,
-0.016760992,
-0.0023748088,
0.015206816,
0.020070316,
0.002408304,
-0.001034164,
-0.00981409,
-0.0026142995,
0.018609926,
0.038345292,
-0.0027516298,
0.012125258,
-0.0031050039,
0.012078365,
-0.022374786,
0.005268793,
-0.0133176865,
-0.014938854,
-0.015153224,
0.018355364,
0.033012856,
-0.0050142296,
0.0046893265,
-0.0028504406,
0.008956613,
0.010061954,
-0.0041031605,
-0.026474597,
0.008963312,
0.006501416,
-0.001894153,
-0.049438898,
-0.63882023,
-0.03384354,
0.037755776,
0.0026293723,
0.037380632,
0.036817912,
0.0137866195,
0.007221563,
-0.014992447,
0.015086233,
0.006394231,
0.020298084,
0.005921949,
-0.02241498,
-0.008621662,
-0.031699847,
-0.026755957,
-0.031405088,
0.0045687435,
0.0027600036,
-0.034084704,
-0.001900852,
0.0061195707,
0.007616806,
0.019038664,
0.014644097,
0.007114378,
-0.014148368,
0.0046457825,
0.0327181,
-0.028564697,
0.016318856,
0.013672736,
0.019065462,
0.05185055,
0.0039457334,
0.009593022,
0.0012493705,
0.0055568516,
0.040998112,
-0.040890925,
0.0017350508,
0.034915384,
-0.007784282,
-0.028189551,
0.010658169,
0.018851092,
0.025978869,
0.0065047657,
0.00047772512,
-0.012929142,
0.020874202,
-0.022053232,
-0.024545275,
0.032959264,
-0.011441956,
0.0071210773,
-0.00842069,
0.018904684,
0.010584479,
-0.0075498153,
0.016975362,
-0.00079090515,
-0.01753808,
-0.02136993,
0.009646614,
-0.00911739,
0.026621975,
-0.008313506,
0.015983904,
0.015756136,
0.023419837,
-0.012125258,
-0.002478644,
0.02581809,
0.01016244,
0.024598867,
0.020713424,
-0.030440427,
0.014684291,
-0.014349339,
-0.005114715,
-0.008970011,
0.014335941,
0.038452476,
-0.009760498,
-0.015983904,
-0.0018539587,
-0.008802536,
-0.0065181637,
0.019440608,
0.024451487,
-0.010731858,
-0.025148187,
-0.027345471,
0.023955759,
-0.011663024,
0.006843067,
-0.008903021,
0.0033160236,
-0.02477304,
0.0054530166,
-0.009927974,
-0.0023865323,
0.0160107,
-0.00062970957,
-0.047536373,
0.005275492,
0.022401582,
-0.03360237,
0.0022860465,
-0.00109613,
-0.0017484488,
-0.005114715,
0.020244492,
-0.009144186,
0.016506428,
-0.011642927,
-0.0064779692,
-0.018422354,
0.0362016,
-0.021530706,
0.012071666,
0.016600216,
0.0021135465,
0.00744933,
-0.0208876,
-0.015260408,
-0.019253034,
-0.014992447,
0.026621975,
0.026769355,
0.0075163203,
-0.011930986,
0.012674579,
-0.010537586,
0.020499056,
0.000049536244,
-0.017605072,
-0.022468572,
-0.010323217,
-0.004310831,
0.008722147,
0.008119234,
0.00008258657,
-0.012473608,
-0.010483994,
0.02331265,
0.011113703,
0.014992447,
-0.01969517,
-0.002693013,
-0.013987591,
0.014389533,
0.017296916,
0.0046893265,
-0.0004188992,
-0.01155584,
-0.0026578433,
0.0066219987,
-0.0010952926,
0.0135655515,
0.008427389,
-0.0063774837,
-0.016131282,
-0.014858466,
0.005312337,
0.031244311,
-0.025041003,
-0.023955759,
-0.0030363388,
-0.01580973,
-0.011877393,
0.016144682,
0.0020180852,
0.008119234,
-0.007610107,
-0.010765353,
-0.02011051,
-0.0035806356,
-0.018810898,
-0.010015061,
0.008219719,
0.0014453174,
0.019119054,
0.02792159,
0.0021905852,
0.007462728,
-0.0028872853,
0.024732847,
-0.010035158,
0.032932468,
0.0042840345,
0.020137308,
-0.014349339,
-0.044106465,
-0.00051331375,
0.019802356,
0.01997653,
0.020860802,
-0.0014369435,
-0.04169481,
0.02616644,
-0.018810898,
0.012239141,
-0.018569732,
-0.029207805,
-0.023165273,
0.02185226,
-0.009505934,
-0.0012744919,
0.008393894,
-0.011013218,
0.0004999157,
-0.0043342775,
0.021557502,
-0.008347001,
-0.008882924,
-0.012500404,
-0.02074022,
-0.0075163203,
0.004330928,
-0.0011840549,
-0.026394209,
-0.011006519,
0.002240828,
0.029716931,
-0.017806042,
-0.017430896,
-0.023902167,
-0.015046039,
-0.015983904,
-0.01518002,
-0.0032976014,
0.0022776728,
0.00247027,
-0.003208839,
-0.006668892,
0.011636228,
0.025911877,
0.02102158,
0.014764679,
-0.00041303755,
0.008862827,
0.0077306894,
-0.009472439,
0.029368581,
0.0073287473,
-0.013163609,
0.01448332,
-0.0023195418,
0.0045151515,
-0.008641759,
-0.010296421,
-0.016024098,
0.0064009307,
0.010309819,
0.023299253,
0.045151513,
0.018288372,
0.035612084,
0.0063506877,
-0.00250544,
-0.0037347134,
0.0050209286,
0.021959446,
-0.0028269938,
0.0174041,
-0.00515156,
-0.001023278,
-0.038264904,
-0.004434763,
0.031539068,
-0.029716931,
0.010879237,
0.019601384,
0.028216347,
-0.0018975025,
0.01768546,
0.012761666,
-0.003962481,
-0.04496394,
0.029770523,
0.008668555,
-0.0013339459,
0.009184381,
-0.010209333,
-0.006900009,
0.018074004,
0.0055032596,
-0.0045419475,
0.012855453,
0.027211491,
0.004977385,
-0.0134248715,
-0.0010199285,
0.039658304,
-0.022214008,
0.0067291833,
-0.011730015,
0.0060023377,
-0.015474777,
0.01273487,
0.0068564652,
0.036951892,
0.012172151,
-0.00014057512,
-0.013840212,
-0.0215709,
-0.028805861,
-0.00508122,
0.0027097608,
-0.00081183965,
-0.011716617,
-0.004622336,
0.031726643,
-0.019413812,
-0.015514972,
0.015581962,
-0.016586818,
-0.010684965,
-0.038023736,
0.01914585,
-0.0017049051,
0.027345471,
0.0069937953,
-0.011977879,
0.021075172,
0.018368762,
0.008675254,
-0.014094776,
-0.044669185,
-0.0046591805,
-0.0054530166,
-0.01259419,
-0.005171657,
0.015139825,
0.0013230599,
0.017149536,
0.015380991,
-0.009921275,
-0.022575757,
-0.012600889,
0.010805548,
0.009646614,
-0.0007595034,
0.02346003,
0.029422173,
0.04858142,
-0.0135454545,
0.0028152706,
0.028725473,
0.0050075306,
-0.04003345,
0.009599721,
0.008521176,
-0.014429728,
0.021691484,
-0.0025908528,
-0.033307616,
-0.00089097203,
0.013351182,
0.020231094,
0.0024669205,
0.005409473,
0.035826452,
0.005171657,
0.001210851,
-0.010530887,
-0.0053491816,
0.0034098101,
-0.017484488,
-0.03529053,
-0.014416329,
0.0048702005,
-0.0024351003,
0.014282349,
-0.02415673,
-0.008903021,
0.0015190068,
0.006836368,
-0.0045854915,
-0.012788462,
-0.008018748,
0.00016402175,
-0.014148368,
0.015702544,
-0.007871369,
-0.02324566,
-0.01712274,
-0.005700881,
-0.021745076,
0.005205152,
0.0033645916,
-0.006521513,
-0.008681953,
-0.0025875033,
0.009948071,
-0.0026578433,
0.009914576,
0.035665676,
-0.011100305,
0.0043811705,
0.006528212,
-0.008903021,
-0.011428558,
0.027492851,
-0.02241498,
-0.009633216,
0.0030614603,
0.002776751,
0.0051281136,
-0.03459383,
0.0008135144,
0.0062602507,
-0.010256227,
0.030092077,
-0.022870515,
0.00086920016,
-0.010202634,
0.01315691,
0.03014567,
-0.017283518,
-0.027050715,
-0.015488175,
-0.005958794,
-0.012071666,
-0.023165273,
-0.0005610444,
-0.02477304,
-0.007074184,
0.009907877,
0.006076027,
-0.010202634,
-0.0049740355,
-0.011750112,
-0.0136995325,
-0.027251685,
0.009144186,
-0.0018640072,
-0.009834187,
0.0031954409,
0.019239636,
-0.0025808043,
0.0016169802,
0.00025184194,
0.0070071933,
-0.0034868491,
-0.0065818047,
0.0059319977,
-0.0012744919,
-0.010798849,
-0.027573239,
-0.0062200567,
0.015032641,
0.019507598,
-0.021128764,
-0.040676557,
-0.041132092,
-0.008802536,
-0.007402437,
0.008440788,
0.0024250515,
-0.014295747,
0.005583648,
0.00076662115,
-0.0076971943,
-0.016734196,
0.020284686,
-0.03354878,
-0.0136995325,
0.025844887,
-0.007616806,
0.023259059,
0.006186561,
-0.015702544,
0.00080262846,
0.0046256855,
-0.027023917,
-0.028430715,
-0.0034366064,
-0.0070004943,
0.030654795,
0.027546443,
0.04032821,
-0.016787788,
-0.0064344257,
0.0010768702,
0.02561712,
0.008152729,
-0.004860152,
0.03384354,
-0.023768187,
-0.0011480476,
0.020177502,
-0.0071813683,
0.025322363,
-0.0010885936,
0.0016404268,
0.015327398,
-0.0047931615,
-0.031699847,
-0.008896322,
-0.017310314,
-0.038479272,
0.020177502,
0.007958457,
0.0043275785,
-0.026849743,
-0.0033880384,
0.036496356,
0.01990954,
0.030520815,
-0.012815259,
0.021423522,
-0.014925456,
0.016814584,
-0.012346326,
0.0026963626,
0.011294577,
0.008132632,
0.014416329,
-0.0056908326,
0.015139825,
0.013867008,
0.0056841336,
0.0035270434,
0.009184381,
0.005483162,
0.011307975,
-0.008970011,
-0.0026092753,
-0.011837199,
-0.009974867,
-0.011723316,
-0.005483162,
-0.012574093,
-0.034352664,
0.009914576,
0.0064478237,
-0.018074004,
0.023419837,
-0.014912058,
-0.035049364,
-0.0039524324,
-0.017243324,
0.021557502,
-0.04324899,
0.007603408,
0.035397716,
0.005416172,
-0.00800535,
0.011569238,
-0.0037414127,
-0.012915744,
0.033789948,
0.032557324,
-0.029288193,
-0.029207805,
0.0132908905,
-0.0010944552,
-0.008326904,
-0.04134646,
0.025697509,
0.014376135,
0.022816923,
0.00085747684,
-0.013800018,
-0.026193237,
0.0031234263,
-0.008936516,
-0.0012962638,
0.0037514612,
-0.0067124357,
-0.010457198,
0.028779065,
-0.01990954,
0.010323217,
-0.0058650076,
-0.01677439,
-0.007764185,
-0.02248197,
-0.007040689,
0.005409473,
0.012306132,
0.023647603,
-0.013056424,
0.020284686,
0.0038117524,
-0.006360736,
0.012862152,
0.01002176,
-0.012299433,
0.038827624,
-0.006374134,
-0.006920106,
0.01775245,
0.019829152,
0.0057812696,
-0.02609945,
-0.017002158,
-0.006457872,
-0.03981908,
0.00925807,
0.018435752,
0.01698876,
-0.046973653,
0.014188562,
-0.017390702,
0.009546129,
-0.029341785,
0.00061798625,
0.016667206,
-0.027600035,
-0.004622336,
0.0028387173,
-0.020713424,
-0.0061128717,
0.00052587443,
0.010497392,
0.0021453667,
-0.00925807,
-0.055092886,
0.040247817,
-0.0019963132,
0.042981025,
-0.015863322,
-0.010664868,
-0.022790127,
-0.035880044,
0.01030312,
-0.027894793,
-0.0528956,
-0.014255553,
0.0048902975,
-0.011656325,
-0.0036576746,
-0.008300108,
0.028216347,
-0.0027198093,
0.01301623,
0.010417003,
-0.015407787,
0.00043794958,
-0.0035002471,
-0.011817102,
0.01134817,
0.010008362,
-0.0003569331,
-0.006327241,
0.00092195504,
0.010403605,
0.0028487658,
-0.010088751,
-0.02826994,
0.030761981,
-0.0025439595,
-0.0073287473,
-0.0028135958,
0.010182537,
-0.011917588,
0.01823478,
0.014577106,
-0.043490153,
0.0041333064,
0.016881576,
-0.013800018,
0.0014989097,
-0.014282349,
-0.02450508,
0.0064009307,
-0.00049782224,
-0.019708568,
-0.0029241298,
-0.023272457,
0.028671881,
0.017350508,
-0.011743413,
-0.034057908,
0.010973023,
-0.034218684,
-0.014268951,
-0.0066923387,
-0.01795342,
-0.0034634024,
0.0061966097,
0.0012761666,
0.026327219,
-0.014496718,
0.009438944,
-0.005191754,
-0.031351496,
-0.011730015,
-0.0327181,
0.03070839,
0.011448655,
-0.0327181,
-0.015367593,
0.011589335,
-0.010550984,
-0.0029710233,
0.008320205,
-0.006437775,
0.010001663,
-0.01168982,
0.031110331,
-0.0064746197,
0.0043409765,
0.010363411,
-0.019507598,
-0.0027784258,
0.016720798,
0.00005134184,
-0.028189551,
-0.020619638,
-0.010812247,
0.012018073,
-0.0073756403,
-0.010805548,
-0.003738063,
-0.004588841,
-0.020284686,
0.002979397,
0.03001169,
0.005881755,
-0.017899828,
-0.007965156,
-0.019467404,
-0.0001786759,
0.0025389353,
-0.0063841827,
0.0066387462,
-0.015166622,
0.011488849,
0.0016940192,
-0.000602076,
-0.0005120577,
-0.011421859,
0.009914576,
-0.011194092,
0.002811921,
-0.01733711,
0.017792644,
0.005687483,
0.0067660282,
-0.0011061786,
-0.007047388,
-0.009773896,
-0.024210323,
-0.007784282,
-0.013089919,
-0.015019243,
-0.034433052,
0.025791295,
-0.015890118,
0.012848754,
0.0025942023,
-0.015555166,
-0.03188742,
0.042150345,
0.18360722,
0.005791318,
0.00654161,
0.02540275,
-0.013947397,
0.0051113656,
0.017310314,
-0.00093535316,
-0.0036007327,
0.010477295,
0.010946227,
0.0066253482,
-0.0051180646,
-0.0007260082,
0.012064967,
0.0021956095,
-0.008125933,
0.0012987759,
-0.014242155,
-0.0134382695,
0.017779246,
0.0076703983,
0.003892141,
-0.015139825,
0.031726643,
0.017564876,
-0.017551478,
0.015836526,
0.002776751,
-0.0135990465,
-0.022870515,
0.0051113656,
0.0035839851,
0.00542957,
0.028323531,
-0.010041857,
-0.031405088,
-0.010216032,
0.015153224,
0.015340797,
0.006354037,
0.0028872853,
-0.03730024,
-0.015447981,
0.0012971011,
0.009894479,
0.0015298927,
-0.01231953,
-0.0062803477,
0.007891467,
-0.030735185,
-0.012306132,
0.016627012,
0.009948071,
0.0034366064,
-0.021209152,
0.0389884,
0.025844887,
0.012172151,
0.02276333,
-0.016184876,
0.0023898818,
-0.014496718,
0.014335941,
-0.035585288,
0.024062943,
-0.021061774,
-0.024036147,
-0.0031552468,
-0.014027785,
0.005248696,
-0.0035873346,
-0.032048196,
0.00876904,
0.010195935,
-0.0047161225,
0.0070272903,
0.034486648,
0.0013532056,
-0.006354037,
0.0026879888,
0.00061673013,
-0.039711896,
0.017940022,
-0.031297904,
-0.020499056,
0.029824115,
0.0073220483,
-0.022307795,
0.00052754924,
0.0013372954,
-0.022160416,
-0.008179525,
-0.024371099,
0.029743727,
-0.014027785,
-0.008581467,
0.012862152,
-0.007462728,
0.009787294,
-0.0362016,
0.062542215,
-0.0069469023,
0.014027785,
-0.0063305907,
0.012493705,
-0.0132439975,
-0.015193418,
-0.0058918037,
0.016144682,
0.009331759,
-0.0313247,
-0.0025221878,
-0.010356712,
-0.016198274,
0.023419837,
0.005952095,
-0.036308784,
0.009686808,
0.0015131452,
0.010879237,
-0.01942721,
0.005818114,
0.010658169,
-0.026648771,
-0.005030977,
-0.008239816,
0.0038318494,
-0.001576786,
-0.042766657,
-0.0037079174,
-0.0018288373,
0.030038485,
0.024384497,
-0.005630541,
-0.011381665,
0.024170129,
-0.0012359725,
0.0018020411,
0.030333243,
-0.0028487658,
-0.002811921,
0.030628,
-0.0033277469,
-0.00079467334,
-0.0034500044,
0.0037447622,
-0.012265938,
-0.005312337,
0.0027047365,
-0.014282349,
-0.012915744,
-0.012292734,
-0.003305975,
0.0056070946,
0.010296421,
-0.019641578,
-0.025094595,
0.002317867,
0.031163923,
-0.017779246,
0.0136258425,
0.022495368,
0.0014319193,
-0.019159248,
0.002282697,
-0.1691373,
0.01489866,
0.040488984,
-0.018207984,
0.030601203,
0.020070316,
0.002255901,
-0.0015642253,
-0.015836526,
-0.011408461,
0.029395377,
0.022106824,
-0.033629168,
-0.019829152,
0.0222676,
-0.0062468527,
-0.008038845,
0.046035785,
0.010463897,
0.020164104,
0.03864005,
-0.020927794,
0.008722147,
-0.034567036,
0.007255058,
0.02185226,
0.027600035,
-0.023714593,
0.017417498,
-0.0049304916,
0.015769534,
-0.0045151515,
0.022495368,
0.0028705376,
0.026956927,
-0.02540275,
-0.011395063,
0.015930312,
0.0059185997,
0.01977556,
0.023058088,
0.01078545,
0.0062133577,
-0.005185055,
-0.031163923,
0.0396851,
-0.0024669205,
0.010249528,
0.039604712,
-0.03180703,
0.021530706,
-0.006153066,
0.010236129,
0.017296916,
0.034888588,
0.012842055,
0.017578274,
0.013840212,
-0.014295747,
-0.026648771,
-0.0023580613,
-0.011053412,
0.03277169,
-0.0055434536,
0.0264478,
-0.027760813,
-0.004029471,
0.008306807,
-0.010678266,
0.010423702,
-0.04260588,
-0.011515645,
-0.01657342,
0.00009326317,
0.015635554,
0.006340639,
-0.010537586,
0.013987591,
-0.0004999157,
-0.0030229408,
-0.024411293,
-0.0028152706,
-0.008072341,
-0.009693507,
-0.011127101,
0.023446633,
0.023004495,
0.02165129,
-0.004712773,
0.0018824296,
0.041373257,
-0.028296735,
0.003334446,
-0.00033620794,
0.0049740355,
0.023513623,
0.015836526,
0.0033377956,
-0.004364423,
-0.006042532,
0.022187212,
-0.037059076,
0.006374134,
0.0021822115,
-0.008943215,
-0.0104438,
-0.030065281,
-0.011254383,
0.024612265,
-0.011857296,
0.008735545,
0.00026272787,
0.0029526008,
0.012346326,
-0.009713605,
0.009124089,
0.0006862327,
0.014737883,
0.018810898,
-0.038479272,
0.03767539,
0.017069148,
0.0061631147,
-0.000716797,
-0.00890972,
-0.030333243,
-0.13258736,
-0.04600899,
-0.0036375774,
-0.020003326,
-0.014242155,
0.022294397,
0.003724665,
0.009023604,
-0.015300602,
0.0073421453,
-0.013177007,
0.01259419,
-0.009144186,
-0.01607769,
0.011817102,
-0.008554671,
-0.009834187,
-0.009660012,
-0.02283032,
0.035129752,
-0.0062200567,
-0.014161766,
0.017940022,
-0.012091763,
0.0025523333,
0.0064210277,
-0.021731678,
0.024652459,
0.005643939,
0.029207805,
-0.0052788416,
0.011609432,
0.004622336,
-0.01518002,
-0.027278481,
-0.005650638,
-0.019668374,
-0.013357881,
0.029556153,
-0.021463716,
0.0139072025,
0.0010023435,
0.022214008,
-0.005268793,
0.01921284,
-0.0022441775,
-0.011120402,
-0.011629529,
0.0132640945,
-0.0010216032,
-0.014268951,
-0.00091441866,
0.008246515,
0.0007984415,
0.009445643,
0.0137464255,
0.017417498,
0.0002353037,
-0.01761847,
0.003925636,
0.012487006,
0.021450318,
-0.010906033,
0.011877393,
0.006397581,
-0.03906879,
0.0026209985,
-0.016091088,
0.009378653,
-0.016104486,
-0.004823307,
0.008393894,
-0.0033243974,
-0.018810898,
-0.00036049198,
0.011582636,
-0.017216526,
-0.02442469,
0.010008362,
-0.020432064,
-0.01489866,
-0.011100305,
-0.0050644726,
-0.001510633,
0.016801186,
0.024491683,
-0.017296916,
0.003815102,
-0.01976216,
-0.038211312,
-0.030520815,
0.013337784,
0.0077239904,
-0.010128945,
0.008728846,
0.018408956,
0.003012892,
-0.0050845696,
0.036871504,
0.012888948,
-0.021972844,
-0.022160416,
-0.054985702,
0.027077511,
-0.0030916058,
0.0028755618,
0.004119908,
-0.012493705,
0.021423522,
-0.0137129305,
0.024344303,
-0.0136124445,
-0.02979732,
0.008956613,
-0.0015340797,
-0.0037581602,
-0.018288372,
0.00010079958,
0.031565867,
-0.00055225194,
0.023419837,
-0.0030983048,
0.015702544,
0.0062669497,
0.030065281,
0.012587491,
-0.0036811212,
0.017765848,
-0.021959446,
0.008775739,
-0.008360399,
-0.01962818,
0.0020900997,
-0.031029943,
-0.010872538,
-0.0014620649,
-0.011421859,
-0.012728171,
-0.021396726,
0.034486648,
0.027975181,
-0.0018908033,
-0.010195935,
-0.035210144,
0.01969517,
0.0036610242,
0.009110691,
-0.0075632134,
-0.050698318,
0.006494717,
-0.0009847585,
-0.017913226,
0.023017893,
0.023620807,
-0.007871369,
-0.027425861,
-0.007462728,
-0.029958097,
0.014335941,
-0.011656325,
-0.02171828,
-0.015581962,
-0.01127448,
0.018784102,
-0.012587491,
0.000027162505,
0.00081225834,
-0.004602239,
-0.03389713,
-0.007214864,
0.022776728,
-0.007268456,
-0.0410785,
0.002178862,
0.0029944698,
-0.025161585,
0.018341966,
-0.0132774925,
-0.00856137,
0.010798849,
-0.01273487,
0.010082052,
-0.0051348126,
-0.0129559385,
-0.03376315,
0.0033478441,
0.02631382,
0.027734015,
-0.020485656,
0.014469922,
0.009994964,
-0.0012895648,
-0.0063004447,
0.024451487,
-0.0017250022,
0.010041857,
0.012286035,
0.013947397,
0.011093606,
0.0045419475,
0.0036007327,
0.035612084,
0.014764679,
0.014657495,
0.0045486465,
-0.024344303,
-0.0137732215,
0.016050894,
-0.030440427,
-0.029958097,
-0.029582951,
0.0043543745,
0.0135320565,
-0.0019510947,
0.019587986,
0.0032842031,
-0.013351182,
0.00911739,
-0.00654161,
-0.0015374292,
-0.005295589,
0.018261576,
0.009371954,
0.029582951,
-0.0012234118,
0.012279336,
0.015005845,
0.01649303,
0.026421005,
-0.0137598235,
0.02484003,
0.011750112,
0.0064076297,
-0.0135454545,
-0.02143692,
-0.00807904,
-0.015019243,
-0.016412642,
0.027573239,
0.031110331,
-0.024665857,
0.08510458,
0.0045854915,
-0.0069937953,
-0.009331759,
-0.012158753,
0.02115556,
0.010758654,
0.026836345,
-0.03472781,
0.014885262,
0.029234601,
-0.016546624,
0.026782753,
-0.035344124,
-0.024384497,
0.02944897,
-0.016801186,
0.008280011,
0.0028068968,
-0.005526706,
0.039175972,
0.000105562176,
0.0032205624,
-0.0026745908,
-0.04844744,
-0.019815754,
0.010825645,
-0.023339447,
-0.014443126,
-0.03215538,
-0.0039993254,
0.0135253575,
-0.030306447,
-0.00988108,
0.026273625,
-0.020525852,
-0.01803381,
-0.0035270434,
-0.007844573,
0.017926624,
0.010973023,
0.03258412,
-0.026903335,
-0.019293228,
-0.008574768,
-0.0028655133,
-0.02944897,
-0.007275155,
-0.0039457334
] |
Hepatocellular carcinoma (HCC) is a fatal disease, primarily due to the limited effective therapies available for patients with advanced or recurrent stages of the disease. Therefore, in order to improve patient prognosis, it is important to identify an informative biomarker for HCC progression, as well as a molecular target for therapy. Neurotrophin receptor-interacting melanoma antigen-encoding protein (NRAGE), a member of the type II melanoma-associated antigen family, mediates apoptosis and cell death through interactions with a wide range of proteins, and is implicated as a tumor suppressor or oncoprotein depending on cell type. However | [
-0.031046873,
0.003246808,
0.0069629136,
-0.028597206,
0.0034681433,
-0.0043301866,
-0.02482951,
0.013712812,
-0.02857058,
-0.011263145,
0.01319359,
-0.011842279,
-0.0035380388,
0.005208872,
-0.008294255,
0.0012231696,
0.048114665,
-0.0002879025,
-0.0072358386,
0.0025328763,
-0.02838419,
0.010377804,
0.004436694,
-0.011156638,
-0.010005028,
0.027745146,
0.010371147,
-0.042203512,
0.013592992,
-0.019424265,
0.005578319,
0.00035800593,
-0.0071093612,
0.013792693,
0.0023664588,
0.013566365,
0.0017773403,
-0.0033865988,
0.021155009,
0.005794662,
0.024443422,
-0.011369652,
0.0066999737,
0.004436694,
0.00041105156,
0.0089998655,
0.013845947,
-0.03812961,
-0.03946095,
0.010883713,
0.00919291,
-0.005851244,
-0.022712678,
-0.031472903,
0.016601823,
-0.0020186459,
-0.010890369,
0.021394651,
0.023870945,
-0.023591364,
0.009146313,
0.00042353288,
-0.033816062,
0.012188427,
0.017533762,
0.02315202,
-0.011602637,
0.012674367,
-0.014245349,
0.014338543,
0.032964002,
0.031845678,
-0.018705342,
-0.011176608,
0.008087897,
-0.032857496,
-0.021607665,
0.003651203,
-0.008440702,
0.0032584572,
0.02857058,
-0.01428529,
-0.009019836,
0.023538109,
0.03032795,
-0.004992529,
-0.0206491,
-0.0079680765,
0.021833993,
-0.0016550233,
0.023231901,
0.02022307,
0.0021567724,
0.00037818405,
-0.0011033489,
-0.0054584984,
0.021407964,
0.017760089,
-0.0024979287,
-0.019038176,
0.0028241072,
0.019144684,
-0.012221711,
-0.01145619,
-0.020116564,
0.015390302,
-0.0048094695,
0.01428529,
0.035892956,
0.0032601214,
-0.0025794732,
0.037703577,
0.0043202015,
-0.0013945798,
0.0154701825,
-0.0058312737,
0.025042525,
0.015922839,
0.004496604,
-0.025042525,
0.00050466147,
0.027771775,
0.005541707,
-0.012847441,
0.024496675,
0.036984652,
-0.023551423,
-0.004266948,
-0.019197937,
0.0010367818,
0.008926641,
0.0129672615,
0.014232036,
0.013306754,
0.011156638,
0.013606305,
-0.022712678,
-0.013699499,
-0.0067332573,
-0.0241239,
0.017533762,
0.039647337,
-0.0057780202,
0.0036778296,
-0.03919468,
0.01327347,
0.023684558,
0.023085454,
0.005348663,
0.02345823,
-0.0025495181,
-0.023444915,
0.016442062,
-0.031046873,
-0.019211251,
0.009053119,
0.0035613372,
0.019890236,
-0.012268308,
-0.015683196,
0.007428883,
-0.004959245,
0.017933164,
0.015097408,
0.013832633,
0.031126754,
0.008287598,
0.00696957,
0.0005774692,
-0.015230541,
-0.0016125868,
0.03938107,
-0.0068297796,
0.015882898,
-0.01448499,
0.0045931265,
0.011729115,
0.037091162,
-0.013067112,
-0.011096727,
-0.014578184,
0.018758595,
0.025628315,
-0.007681838,
-0.011369652,
0.006653377,
0.039647337,
-0.012401442,
-0.0037310834,
-0.012641083,
0.00083666464,
0.017453881,
-0.0041837394,
-0.018452387,
-0.63094914,
-0.026706701,
0.025228912,
0.0109569365,
0.0073556593,
0.0108704,
0.013499798,
-0.0040739034,
-0.009033149,
0.019610653,
-0.0079680765,
0.016189108,
-0.0040739034,
-0.0008092057,
-0.0147645725,
-0.016029347,
-0.03565331,
-0.017760089,
-0.0059044976,
-0.001925452,
-0.01713436,
0.00660678,
-0.011436219,
-0.0027874953,
-0.013413261,
0.027012909,
0.024922704,
-0.015709825,
-0.006277273,
0.038315997,
-0.0044799624,
0.027612014,
-0.008773537,
-0.004842753,
0.05735417,
-0.012641083,
0.025468554,
0.0044699777,
0.010637415,
0.020462712,
-0.015563377,
-0.005175588,
0.013000545,
-0.010590818,
-0.03192556,
0.010717295,
0.0124813225,
-0.0014686356,
-0.008593806,
-0.011076758,
-0.017693521,
0.008320881,
-0.011362996,
0.009792013,
-0.027745146,
-0.00866703,
0.02291238,
-0.024430107,
-0.00038712902,
0.018212745,
-0.011775712,
0.019237878,
-0.004280261,
-0.03213857,
0.006030975,
0.0072558085,
-0.02361799,
0.002501257,
-0.013533082,
0.01658851,
0.0116625475,
0.025934523,
-0.009632252,
-0.0027908236,
0.03299063,
0.03938107,
-0.0011590988,
0.009385955,
-0.015430243,
0.006273945,
0.01036449,
-0.008493956,
-0.02814455,
0.021847306,
0.015203915,
-0.008174434,
-0.014045648,
0.008760224,
0.028543951,
0.020302951,
0.011855592,
-0.008660373,
-0.024603182,
-0.036105968,
-0.011649234,
0.03192556,
-0.015097408,
0.0044433507,
-0.0032534646,
-0.035626687,
-0.0049958574,
-0.024310287,
0.019783728,
-0.013067112,
0.023058826,
-0.00523217,
-0.019118058,
-0.008134494,
0.045505237,
-0.022845812,
-0.014844453,
-0.02170086,
-0.012035323,
-0.014258662,
0.012554546,
-0.015709825,
0.004862723,
0.013899201,
-0.0040372917,
-0.033629674,
0.02931613,
-0.0019171311,
0.014351856,
-0.010051625,
0.008946612,
-0.004569828,
0.0017490493,
-0.015922839,
-0.024723003,
-0.024070647,
0.021301456,
-0.028597206,
-0.0001179485,
-0.0073490026,
0.031259887,
0.000036429858,
0.0067465706,
-0.005711453,
-0.011675861,
-0.030194815,
-0.017200926,
-0.0065102577,
0.00931273,
0.008780194,
-0.010604131,
-0.0016375495,
-0.021833993,
0.006856406,
-0.00061033666,
0.0045332164,
-0.0050990363,
-0.00031785766,
-0.0022682722,
0.006813138,
0.024350228,
-0.018319253,
0.0015277138,
-0.006520243,
-0.0033483228,
-0.00007207964,
0.009705476,
0.01783997,
-0.0058046468,
-0.015243855,
-0.019690534,
-0.02228665,
0.02537536,
0.032537974,
0.0035313822,
-0.014445051,
-0.028091297,
-0.024083959,
-0.035253912,
0.0021068472,
0.00430356,
-0.0069629136,
-0.025109092,
-0.024563242,
0.0066999737,
-0.019850295,
0.011116697,
-0.008014673,
-0.0011823972,
0.0020452726,
0.019224565,
0.03442848,
0.045185715,
0.010477654,
0.017360687,
0.021913873,
-0.039061546,
0.034801256,
-0.025069151,
0.02291238,
0.0016633442,
-0.02596115,
0.017427254,
0.008919985,
-0.002228332,
0.039061546,
0.005551692,
-0.010224699,
0.012348188,
-0.00009953854,
0.008340851,
0.0034015763,
-0.010590818,
-0.0059344526,
0.0011582667,
0.0037843368,
0.0077084647,
-0.011076758,
-0.010497624,
-0.016921345,
-0.0010334535,
-0.0059144828,
0.017946478,
-0.00054709794,
0.005841259,
-0.030727351,
0.0013621283,
-0.010470998,
0.0004322698,
-0.0051223347,
0.0039873663,
0.009239507,
0.01327347,
0.032591227,
0.0018805192,
-0.021381337,
0.0014811169,
0.02440348,
-0.00256616,
-0.005927796,
0.011702488,
0.0005720606,
-0.00404062,
-0.006257303,
0.02896998,
0.0020236385,
-0.0013979081,
-0.002264944,
0.008354165,
0.012854097,
-0.012794187,
-0.0059710643,
0.0013588,
0.010144819,
-0.018572208,
0.024603182,
0.0030121591,
0.033123765,
-0.01729412,
0.0043568136,
0.014445051,
-0.020276325,
0.02588127,
0.019157998,
0.059910346,
0.0027808386,
0.018279312,
-0.013659559,
-0.01822606,
-0.02814455,
-0.0022982275,
0.019331072,
0.011183265,
-0.0056881546,
-0.014831139,
-0.0006910492,
-0.010737265,
-0.009186253,
0.012847441,
-0.024629809,
0.011915502,
0.009678849,
0.015456869,
-0.0044300375,
0.01983698,
0.0076285843,
-0.015976092,
-0.022233395,
0.04449342,
0.025748136,
-0.008047957,
-0.02838419,
-0.022180142,
0.02088874,
-0.0135131115,
0.016069286,
0.021288143,
0.018918356,
-0.0072957487,
0.0042336644,
-0.0154169295,
0.0007596965,
0.015869586,
-0.021301456,
0.008853418,
-0.0064270487,
0.019118058,
0.005162275,
0.011070101,
0.00067815185,
0.014591497,
0.00079838856,
-0.020209758,
-0.0067731976,
-0.030301321,
-0.02026301,
-0.0031785767,
-0.008593806,
0.011183265,
-0.0148710795,
0.0049692304,
0.008939955,
-0.003002174,
0.007588644,
0.0035347105,
0.01266771,
-0.0052987374,
-0.024616497,
0.0069163167,
-0.019384326,
0.033869315,
0.029688906,
-0.0037543818,
-0.0048660515,
0.032298334,
0.009765387,
0.017573701,
-0.01557669,
0.016615136,
-0.020010056,
-0.002349817,
0.009931804,
-0.010550878,
0.007002854,
0.039274562,
0.001822273,
0.0055483636,
-0.022379844,
-0.0060276464,
0.01145619,
0.005911154,
-0.017986417,
0.038821906,
0.01678821,
0.028330937,
-0.011110041,
0.015297108,
0.014192095,
0.018292626,
-0.019251192,
-0.0032368228,
0.0012789195,
-0.0017374001,
0.0015518444,
-0.019410953,
-0.023444915,
0.018958297,
0.009459178,
0.0068963463,
-0.0073290323,
0.023058826,
0.0049792156,
0.024629809,
0.0065934663,
-0.00021301457,
0.005741408,
-0.0068098092,
-0.009079746,
-0.0016400458,
-0.0037843368,
0.009991715,
-0.009013179,
-0.005059096,
-0.011928815,
0.0001160763,
-0.0029106443,
-0.003406569,
0.0062806015,
0.0147645725,
-0.0030537634,
-0.003022144,
-0.03014156,
0.01620242,
-0.010544221,
-0.0034148898,
-0.013446544,
-0.002133474,
-0.037996475,
-0.033070512,
-0.006719944,
0.04297569,
-0.021873932,
-0.00860712,
0.018745283,
0.006230676,
-0.0019986758,
0.0005125663,
-0.01772015,
0.0067898394,
0.024616497,
0.008780194,
-0.008067926,
-0.010737265,
-0.0423899,
-0.005162275,
-0.032298334,
-0.003200211,
-0.02490939,
-0.007016167,
0.008254315,
0.012281621,
-0.017027851,
0.029422637,
0.00029892765,
-0.013699499,
-0.012388129,
0.015283795,
0.0046330667,
-0.01436517,
-0.0066899885,
0.00931273,
-0.02170086,
-0.040126618,
-0.01967722,
-0.002870704,
8.174616e-7,
0.0031652632,
0.007342346,
-0.003276763,
-0.006087557,
0.013100396,
-0.013393291,
-0.007242495,
0.009133,
0.001699124,
0.0056681843,
-0.0064436905,
0.009598969,
-0.004992529,
0.006616765,
-0.01725418,
-0.005511752,
0.030620843,
0.008600463,
-0.019157998,
-0.0026094285,
-0.008247658,
0.0015959451,
-0.014777886,
-0.015190601,
-0.023684558,
0.040659156,
-0.011189922,
-0.04071241,
-0.012880725,
-0.022965632,
-0.020156503,
-0.009013179,
0.0024529959,
-0.029209623,
-0.027665267,
0.017826656,
0.0055716624,
0.004103859,
0.010277953,
-0.03634561,
-0.007375629,
0.024336914,
0.014178782,
-0.005944438,
-0.011063444,
-0.0019138027,
-0.028916728,
0.00569814,
-0.02034289,
-0.020782234,
0.01038446,
0.005884527,
0.041724227,
0.03352317,
0.0045365444,
-0.0020935338,
0.01596278,
0.00373774,
0.015643258,
0.011169951,
-0.013399947,
-0.0017973104,
-0.01959734,
0.029289503,
-0.0084540155,
-0.008939955,
0.023924198,
-0.008480642,
0.023298468,
0.0010426064,
0.0049426034,
-0.028330937,
-0.0125878295,
-0.047076218,
-0.054238833,
0.02428366,
-0.01323353,
0.00812118,
-0.02896998,
-0.016734958,
0.009805326,
0.003860889,
0.0064803027,
-0.007795002,
0.023471542,
0.0013288448,
0.006417064,
-0.004599783,
0.008067926,
0.0018372507,
-0.00090947235,
0.01670833,
-0.010490967,
-0.009046462,
0.01097025,
0.0035746507,
-0.00038463276,
-0.04270942,
0.011176608,
0.0042170226,
-0.034721375,
-0.022273336,
-0.01705448,
-0.02721261,
-0.01901155,
-0.024776258,
-0.0069429437,
-0.015310422,
-0.007928136,
0.01495096,
-0.030966993,
0.0066334065,
0.0011674197,
-0.01208192,
0.02494933,
-0.013592992,
0.009951774,
-0.024083959,
0.030700725,
0.01381932,
-0.01040443,
-0.029209623,
-0.001132472,
0.011602637,
0.014245349,
0.03509415,
0.025468554,
0.009146313,
-0.0069362866,
0.013832633,
0.0000051615466,
-0.03014156,
-0.048167918,
0.021833993,
0.012028666,
0.02709279,
-0.016734958,
-0.026507,
-0.04712947,
0.008926641,
-0.011036817,
-0.018731968,
0.008533896,
-0.025002584,
-0.01381932,
0.027319118,
-0.018372506,
0.0028241072,
0.0042003808,
-0.042176884,
-0.02646706,
-0.011323055,
0.008107867,
-0.001218177,
-0.0154169295,
0.019876922,
-0.009898521,
0.0053719613,
0.020968622,
-0.015124034,
0.013899201,
-0.02022307,
0.0028590548,
0.04177748,
0.005408573,
-0.0011649234,
0.02369787,
0.0011915503,
-0.006350497,
-0.0070960475,
-0.002652697,
-0.010118192,
-0.018332565,
-0.00604096,
0.024070647,
0.007448853,
-0.037996475,
0.015510123,
-0.0097587295,
-0.009199566,
-0.033469915,
-0.017520448,
0.017347373,
-0.036292356,
-0.022113575,
-0.010657385,
0.003491442,
0.008407419,
0.0148710795,
-0.008354165,
-0.0077284346,
0.047315862,
-0.031020246,
0.0060642585,
-0.0017240866,
0.022686051,
-0.0064137354,
0.01220174,
-0.027252551,
-0.036638506,
0.0110101905,
-0.017520448,
-0.02549518,
-0.026866462,
0.0052721105,
0.03243147,
0.03461487,
-0.017374001,
0.017533762,
-0.009259477,
0.0065302276,
0.004872708,
-0.005538379,
0.03727755,
-0.019916862,
0.014431736,
0.0013737775,
-0.008374135,
-0.014791199,
-0.015337049,
-0.02068904,
-0.01212186,
-0.019970115,
-0.022393156,
-0.004163769,
0.019357698,
-0.016282301,
-0.010124848,
-0.011789025,
-0.012594487,
-0.022539604,
0.013433231,
0.009945118,
-0.007874882,
-0.0053586476,
0.0039973515,
-0.009053119,
-0.00023943337,
-0.033895943,
-0.0063005714,
0.0014004044,
-0.021660918,
-0.03994023,
-0.003077062,
-0.027532132,
0.031712543,
0.000017967903,
-0.008746911,
-0.028677085,
0.001840579,
-0.03442848,
-0.012348188,
0.008054613,
0.017507134,
-0.0018006387,
0.023804378,
-0.013146993,
0.023231901,
-0.001141625,
0.01596278,
0.0013063784,
-0.038502384,
-0.000050393337,
-0.019357698,
0.011622608,
0.012381472,
-0.016282301,
-0.015150661,
0.047448993,
0.008873388,
-0.0402065,
0.02478957,
-0.018718654,
-0.004756216,
-0.010064938,
-0.0012190092,
-0.010064938,
-0.0040572616,
0.02814455,
-0.022872439,
-0.011216548,
0.0074688233,
0.0012423076,
-0.013027172,
0.000016407737,
0.026413806,
0.02236653,
0.014791199,
-0.021887247,
-0.023471542,
0.007954762,
-0.01557669,
0.009326044,
0.040153246,
-0.011376309,
0.018665401,
0.015017527,
0.0012439718,
0.007116018,
0.003651203,
-0.014458364,
-0.0079680765,
-0.011982069,
-0.006982884,
-0.00856718,
-0.005448513,
0.016921345,
-0.029289503,
-0.0050258124,
-0.02228665,
-0.030833859,
-0.02240647,
0.021021875,
-0.007608614,
0.0014411766,
-0.015869586,
0.008241001,
-0.024842823,
0.0026310626,
-0.011382966,
0.012361501,
-0.023964139,
-0.0116625475,
-0.013426574,
0.0028157863,
0.008427389,
0.0076219277,
-0.03456161,
0.007116018,
0.005075738,
0.19352373,
-0.006333855,
-0.015882898,
-0.0061308253,
0.0060076765,
-0.010470998,
0.024150526,
-0.00022591194,
0.024017392,
0.020369519,
0.035067525,
-0.010337863,
-0.0195574,
-0.0011216549,
0.008280941,
-0.0299818,
-0.036798265,
0.01329344,
-0.021021875,
-0.010038312,
-0.0032834199,
0.003774352,
0.0022616156,
-0.009093059,
0.022126889,
0.0019204594,
-0.008953269,
0.0043867687,
0.0015851279,
-0.013446544,
-0.029582398,
-0.006729929,
-0.0099784015,
0.0056315726,
0.006004348,
0.007335689,
-0.013686186,
-0.0024130556,
0.001123319,
0.0067565558,
-0.0067731976,
0.021061815,
-0.0074155694,
0.013120366,
0.012700994,
0.0012614456,
0.013386634,
-0.0020718996,
0.0030104949,
-0.0035746507,
-0.07008179,
0.0073290323,
0.03517403,
0.017001225,
-0.014019021,
0.0132535,
0.00018721983,
0.0062406613,
-0.009186253,
0.020742293,
-0.005351991,
-0.005531722,
-0.01862546,
0.036105968,
-0.010537565,
0.03373618,
-0.0074421964,
0.006200721,
0.032777615,
-0.019357698,
0.016615136,
-0.0048760367,
-0.005278767,
-0.007116018,
-0.0007534558,
-0.014737945,
0.0011940465,
0.006257303,
0.0011025168,
0.024656435,
0.017360687,
0.003022144,
-0.011922159,
0.013912514,
-0.03442848,
-0.040579274,
0.01983698,
0.019916862,
-0.0230322,
-0.01721424,
0.024083959,
0.0024862795,
-0.022086948,
0.015004214,
0.0047828425,
0.008560522,
-0.0025811375,
0.0024879435,
0.007315719,
-0.012887381,
-0.027505506,
0.06464992,
0.008939955,
0.008640403,
-0.022060322,
0.00402065,
-0.009998371,
0.012075263,
0.014019021,
0.006856406,
-0.0032318304,
-0.013752753,
0.012441382,
-0.022473037,
-0.0032934048,
0.040392887,
-0.0005953591,
-0.021887247,
0.019517459,
-0.021913873,
-0.014937647,
-0.03759707,
-0.00014935982,
0.039567456,
-0.026773268,
0.005521737,
0.00078049867,
-0.035546806,
0.0072092116,
-0.029156368,
0.006982884,
-0.0015801354,
-0.00048302716,
0.008693657,
0.01998343,
-0.01713436,
0.0040173214,
-0.005182245,
-0.019490832,
0.013000545,
-0.009279447,
0.0043435004,
0.010451027,
0.026400493,
0.00028062172,
0.0087269405,
0.012328218,
0.016974598,
-0.011789025,
-0.015203915,
-0.017347373,
-0.031206634,
-0.01721424,
-0.01099022,
0.015430243,
-0.026839836,
-0.028863473,
-0.01268768,
0.012248337,
-0.010863743,
-0.035227284,
0.008753567,
0.028117923,
-0.01093031,
-0.007868226,
0.0038742025,
-0.16753596,
0.0062073776,
0.03349654,
-0.028490698,
0.016308928,
-0.003920799,
-0.012581172,
-0.013060455,
-0.0041471273,
0.010211386,
0.022060322,
-0.025694882,
-0.02198044,
-0.019623967,
0.02022307,
0.010084908,
0.018172804,
0.04188399,
0.011090071,
-0.0022882423,
0.03032795,
-0.020249696,
0.003464815,
-0.007142645,
-0.018372506,
-0.0062240195,
-0.015097408,
-0.01947752,
-0.011090071,
-0.000925282,
-0.022592857,
0.007542047,
0.015510123,
0.02198044,
0.014644751,
0.010723952,
-0.003614591,
0.0084540155,
-0.025348734,
0.024190467,
0.030461082,
0.023817692,
0.024177153,
0.019038176,
-0.036105968,
0.03482788,
0.012874068,
-0.00143452,
0.029822038,
0.008653717,
0.020010056,
-0.02295232,
0.02107513,
0.020076623,
0.032804243,
0.009552372,
0.017307434,
0.010224699,
0.008207718,
0.013626276,
-0.025681568,
-0.01729412,
0.0015618295,
0.01674827,
0.0012572852,
-0.048860215,
-0.013386634,
0.0142187225,
-0.015723137,
0.0070494507,
-0.02604103,
-0.015669884,
0.013566365,
-0.026014404,
0.035067525,
-0.0018156164,
0.005628244,
0.026400493,
0.0072624655,
0.010151476,
0.01612254,
-0.0006852246,
-0.0263073,
-0.03163266,
0.016655076,
-0.011030161,
0.028597206,
0.013752753,
-0.004296903,
-0.01783997,
0.018106239,
-0.039993484,
0.0034581583,
-0.020795546,
0.0096522225,
0.025535122,
0.0025977793,
-0.0015851279,
-0.008939955,
-0.021780739,
0.031472903,
0.0015967771,
-0.010224699,
0.011995383,
0.046517055,
0.0074155694,
-0.026746642,
0.0077350913,
0.023045514,
-0.0032135244,
-0.007814972,
0.012987232,
0.019384326,
0.011968756,
-0.017973104,
0.03442848,
0.00024234568,
-0.029422637,
-0.017187612,
-0.025282167,
0.07034806,
0.009785357,
0.0155234365,
0.0038176205,
0.012321562,
-0.028543951,
-0.1286608,
-0.016894719,
0.026200792,
-0.0059044976,
-0.017507134,
0.025535122,
-0.00079714047,
0.025774762,
-0.026959656,
0.035067525,
-0.03006168,
0.011795682,
-0.0035646656,
-0.0038808591,
0.020449398,
-0.01220174,
0.025481867,
-0.0024979287,
-0.017547075,
0.036718387,
-0.008334195,
-0.01097025,
-0.0038941726,
-0.013726126,
0.009878551,
0.005202215,
-0.014178782,
0.002973883,
0.0106840115,
0.018705342,
-0.0067332573,
-0.01036449,
0.029715532,
0.009073089,
-0.029529145,
-0.016521942,
-0.0070095104,
-0.012887381,
0.02018313,
-0.013486485,
0.011356339,
0.013439888,
0.011542727,
-0.010590818,
0.0044200523,
-0.0022233396,
-0.028437445,
0.00023360875,
0.035813075,
-0.00069812196,
-0.0026793238,
-0.02345823,
-0.019876922,
-0.008320881,
0.025748136,
-0.027146043,
0.0044999328,
0.032804243,
-0.039647337,
-0.0053020655,
-0.013127022,
0.011090071,
-0.009725446,
0.0061674374,
0.023604676,
-0.012161801,
-0.009705476,
-0.016042659,
0.020582533,
-0.013559708,
-0.011196578,
-0.0021734142,
-0.022512976,
-0.033443287,
-0.012161801,
0.0012356509,
0.004143799,
-0.008886701,
0.00856718,
-0.02428366,
-0.021061815,
-0.020462712,
0.025828017,
-0.0024746303,
0.020422772,
0.013519769,
0.0015593332,
-0.0056681843,
0.0088334475,
-0.00979867,
0.010098222,
0.033816062,
-0.006610108,
-0.0049126484,
-0.003331681,
0.009445865,
0.0015318743,
0.0080213295,
0.02529548,
0.04665019,
-0.007868226,
-0.01503084,
-0.049978543,
0.0148710795,
-0.0043767835,
0.00095939764,
0.021913873,
-0.019584026,
0.018598834,
-0.017014539,
0.013592992,
0.012008696,
-0.0064337053,
0.018013043,
-0.008114523,
0.023418289,
-0.010377804,
-0.0046097683,
0.025907896,
0.0064703175,
0.018212745,
0.022260021,
-0.0013063784,
0.0009643902,
-0.0026293986,
0.0068963463,
0.0020718996,
0.009412581,
-0.009352671,
0.017613642,
0.000896991,
-0.0014128857,
0.016362181,
-0.020795546,
0.002141795,
0.0037244265,
-0.011356339,
-0.021581039,
0.0095457155,
0.025694882,
0.012574516,
0.038768653,
-0.017227553,
-0.026413806,
0.017826656,
-0.013200247,
0.0017340716,
-0.006287258,
-0.031206634,
0.011789025,
0.007588644,
-0.0073822862,
0.030221442,
0.017813344,
-0.010803833,
-0.014005708,
-0.044866193,
-0.011063444,
-0.009352671,
-0.024443422,
-0.03442848,
-0.035493553,
0.027292492,
0.009419238,
0.0067266007,
0.015603317,
0.02076892,
0.0022066978,
-0.023950825,
0.013885887,
0.035520177,
0.00462641,
-0.026160851,
0.0032601214,
0.019118058,
0.0027492193,
0.012394785,
-0.009445865,
-0.017041165,
0.00973876,
-0.0038808591,
-0.0045065894,
-0.0015909525,
0.0037111132,
-0.015483497,
0.011962099,
0.009179597,
-0.0004276933,
-0.012834128,
-0.0035846357,
0.025774762,
-0.011875562,
0.001604266,
0.024989272,
0.007562017,
0.00406059,
-0.0040539335,
0.005428543,
-0.0010717296,
-0.00965888,
0.0118822185,
0.03264448,
-0.0018272656,
0.009811983,
-0.008853418,
-0.008873388,
0.0011457853,
0.021008562,
-0.023511482,
-0.013766066,
0.002125153,
-0.016974598,
0.011868905,
0.014338543,
0.0056881546,
0.0028873459,
-0.021527784,
-0.00569814,
-0.0063405116,
-0.00066899887,
-0.011642577,
0.028996607,
0.015949465,
0.011349683,
-0.0028191146,
-0.01044437,
0.0017656911,
0.008780194,
0.011802338,
-0.014711319,
0.020542592,
-0.04478631,
-0.0014569863,
-0.03844913,
-0.03299063,
0.00051714276,
-0.026480373,
0.0018555566,
0.008653717,
-0.001246468,
-0.011249832,
0.08765549,
0.015869586,
-0.024470048,
0.001416214,
-0.014378483,
0.03685152,
0.0040905452,
0.01983698,
-0.023112081,
-0.03778346,
0.0056049456,
-0.031685915,
0.025388673,
-0.04965902,
-0.014578184,
0.006247318,
-0.0074555096,
0.026733328,
0.030035054,
-0.013013858,
0.011642577,
-0.005398588,
-0.0013529754,
0.023777751,
-0.037996475,
0.014911019,
0.03408233,
0.017813344,
-0.0020502652,
-0.022166828,
-0.010098222,
-0.00284907,
0.0017873254,
-0.00030974482,
0.0068164663,
-0.007721778,
-0.0057047964,
0.0012098561,
0.008300912,
0.034375224,
-0.0035713224,
0.021168323,
-0.017706836,
-0.033656303,
0.014311916,
-0.0031036888,
-0.035626687,
-0.010537565,
0.009871894
] |
The stable contact of ISW2 with nucleosomal DNA approximately 20 bp from the dyad was shown by DNA footprinting and photoaffinity labeling using recombinant histone octamers to require the histone H4 N-terminal tail. Efficient ISW2 remodeling also required the H4 N-terminal tail, although the lack of the H4 tail can be mostly compensated for by increasing the incubation time or concentration of ISW2. Similarly, the length of extranucleosomal DNA affected the stable contact of ISW2 with this same internal nucleosomal site, with the optimal length being 70 to 85 bp. | [
-0.025684873,
0.007993555,
-0.00011359283,
-0.008013843,
-0.041658454,
0.008473708,
-0.008331691,
-0.0102387825,
0.004970611,
0.008460183,
-0.00022338163,
0.015243207,
0.004801543,
0.011658957,
0.010502529,
0.013789219,
0.015513717,
-0.010955633,
-0.0035233856,
0.0035943943,
-0.050774623,
-0.008331691,
-0.015094427,
0.0029705318,
0.0076013156,
0.011760399,
0.015770702,
-0.022574013,
-0.0076621803,
-0.015310835,
0.0071346867,
0.014418154,
-0.016595755,
0.02446758,
-0.0032461134,
-0.01487802,
0.013687778,
-0.0020812321,
0.013802744,
-0.012822148,
0.012071485,
0.010881242,
-0.012842436,
-0.0016737772,
-0.023980662,
0.0059207757,
0.014688663,
-0.02174896,
0.0044126855,
0.0171503,
-0.0011479745,
0.02805183,
-0.018678678,
-0.0057381815,
-0.022574013,
-0.016731009,
0.03408419,
0.014147644,
0.00027283415,
-0.016703958,
0.0032866898,
0.00029967376,
-0.018299965,
0.012517825,
-0.023372017,
0.004270668,
-0.0034067284,
0.0030381593,
-0.0016780039,
0.0005076279,
0.032785747,
0.008818608,
-0.030188855,
0.0062961075,
0.027213251,
-0.019666037,
-0.008291115,
0.0061777597,
0.019192645,
0.018299965,
0.016149415,
-0.020842753,
-0.0077095195,
0.017677793,
0.009623374,
0.02261459,
0.0076216036,
0.0003296834,
-0.010475478,
0.010854192,
0.02891746,
0.040468212,
0.0023246906,
0.011158515,
-0.017231451,
-0.0013449392,
-0.0071685,
0.009630136,
-0.0063130143,
-0.015797751,
-0.015189106,
0.0062961075,
-0.008135572,
-0.022438759,
-0.020207057,
0.0077636214,
0.013085894,
-0.024007713,
-0.0016889934,
0.0035876315,
-0.01000885,
0.022993304,
0.005741563,
-0.018178236,
0.017880674,
-0.021194415,
0.016987994,
-0.014742765,
0.0070467712,
0.0008195591,
0.020234106,
0.035003923,
0.011719822,
-0.025022125,
0.0076554175,
0.037465557,
-0.027172673,
-0.008297877,
-0.016419923,
-0.008534573,
0.02318266,
0.0024954497,
0.010894768,
0.0052005444,
-0.019787766,
0.01265308,
-0.00032059598,
-0.017826572,
0.0041624643,
-0.033948936,
0.0207616,
0.031595502,
0.0019273799,
-0.007202314,
0.02279042,
0.0006280891,
-0.003322194,
0.0068202196,
-0.007790672,
-0.010090003,
-0.0062048105,
-0.010414613,
0.008142334,
0.0023585043,
0.016392874,
0.052181274,
0.0028690908,
0.0079665035,
-0.035139177,
-0.004507364,
-0.032461133,
0.00343547,
0.014174695,
0.016514601,
0.024981547,
0.03121679,
-0.014593985,
-0.011625144,
-0.0055352994,
-0.009846544,
0.0000056796416,
-0.008717167,
-0.031866014,
0.019206172,
-0.013227913,
-0.0031379096,
0.013417269,
0.023818357,
-0.014823918,
-0.031460248,
-0.010110291,
0.00996151,
0.016203515,
0.017069146,
-0.043065105,
-0.0064245993,
0.0149185965,
-0.009339339,
0.018935662,
0.011746873,
0.009447543,
-0.0010532961,
-0.0106851235,
0.005768614,
-0.63753664,
-0.02204652,
0.01445873,
-0.030242957,
-0.0047170087,
0.035869554,
-0.00019844405,
0.025941856,
-0.0046527623,
0.01275452,
-0.021316145,
0.001959503,
0.014242322,
-0.02360195,
-0.032785747,
-0.02945848,
-0.00062682113,
-0.0141611695,
0.014621036,
-0.006759355,
-0.023953611,
0.019571358,
-0.0069385674,
0.009116168,
0.019584885,
-0.013390218,
0.0057178936,
-0.03522033,
-0.0286199,
0.019571358,
-0.01947668,
0.025860703,
-0.021532552,
0.028755154,
0.048529394,
-0.00078954943,
0.00024979858,
0.0130250305,
0.014025915,
0.024481105,
-0.012389333,
-0.022695743,
0.01238257,
0.0060864626,
-0.014418154,
0.0128694875,
0.0013694541,
0.020964483,
0.0027355268,
-0.031324994,
0.0053155106,
-0.018665152,
-0.009947985,
0.0028504934,
0.004297719,
-0.004067786,
0.017055621,
-0.010793327,
0.011577805,
0.0016416542,
0.009853307,
0.016528128,
-0.016798638,
-0.012903301,
-0.016176466,
-0.010921819,
-0.029079765,
0.009048541,
0.022817472,
0.0130250305,
0.003339101,
0.044444703,
0.010448428,
0.005170112,
-0.004071167,
0.03835824,
0.0075472137,
0.004040735,
-0.013126471,
0.025644297,
0.0112193795,
-0.020261157,
-0.012686893,
0.0012747758,
0.017380232,
0.0025799838,
-0.028755154,
0.019611936,
-0.006897991,
-0.03465226,
0.0041928967,
-0.0007498184,
-0.0031074772,
-0.021167364,
-0.021843638,
0.030270008,
0.022357605,
-0.007479586,
0.010996209,
-0.0064009298,
-0.018340541,
0.0010693576,
0.0011589639,
-0.011686008,
0.037032742,
0.0041286503,
-0.019287324,
0.020355836,
0.046527624,
0.00590725,
0.024886869,
-0.0100832395,
-0.02147845,
0.00032334332,
0.0106174955,
-0.019517256,
0.025373787,
0.003665403,
-0.030405262,
-0.017285554,
0.015973583,
0.0016763132,
-0.004307863,
-0.0052580275,
-0.014134118,
0.024413478,
0.014174695,
-0.007986791,
-0.0034828093,
-0.014823918,
0.0037059796,
-0.0052005444,
0.026293518,
-0.028944511,
0.033462018,
0.024562258,
0.027470235,
-0.0043957788,
0.011929466,
-0.0429569,
-0.035680197,
0.005082196,
0.009062067,
-0.0108406665,
-0.0070873476,
-0.0358425,
-0.031784862,
0.00615409,
0.022425234,
-0.019977123,
0.0117536355,
0.004666288,
-0.020491092,
0.01917912,
0.024170019,
-0.010434902,
-0.015500192,
-0.04117154,
-0.012402859,
-0.006218336,
-0.00041252692,
0.022574013,
-0.0047711106,
0.0072428905,
-0.022371132,
-0.017393759,
0.009041779,
-0.010123816,
0.00219958,
-0.034111243,
0.01193623,
0.00020161408,
-0.028457595,
-0.005318892,
-0.007790672,
0.011124701,
0.008561624,
0.0032951431,
-0.031784862,
-0.0087239295,
-0.0055251555,
0.024156494,
-0.00966395,
-0.0022452285,
0.021221466,
0.0035504366,
0.0372762,
-0.017380232,
0.0024768522,
0.013451083,
0.0051904,
-0.025806602,
-0.0034134912,
0.011334346,
0.015202631,
-0.012544876,
0.010583682,
-0.0003244,
-0.00034954894,
0.03086513,
0.038195934,
0.014255848,
-0.0030415407,
-0.013498422,
0.0070941104,
-0.013505184,
-0.0051396796,
-0.021965368,
0.023967138,
0.003895336,
-0.017637216,
-0.01472924,
-0.0012646316,
0.0032292067,
0.010259071,
0.013532235,
-0.011841551,
0.0028690908,
-0.002857256,
0.028214136,
0.003205537,
-0.0015385225,
0.023277339,
-0.0035064789,
-0.0045242705,
-0.003655259,
0.0003313741,
0.0035571994,
0.016947417,
0.0056840796,
-0.008730693,
-0.00701972,
-0.009819493,
0.007885351,
0.009548984,
0.022249402,
0.027808372,
-0.013762169,
0.05153205,
0.0010795018,
0.013748643,
0.0008559088,
-0.00095185515,
-0.025738975,
0.026131213,
0.0017270338,
0.03925092,
0.021437874,
-0.006329921,
0.0035504366,
0.008311403,
0.005061908,
-0.014134118,
0.026009483,
0.0070873476,
-0.005345943,
0.0056705545,
0.020125903,
0.016419923,
0.031866014,
0.0012823839,
0.012511062,
0.0047778734,
-0.015243207,
0.006245387,
-0.015378462,
-0.00035905902,
-0.002777794,
-0.0075472137,
-0.0007299528,
-0.0026239417,
0.022492861,
0.0148509685,
-0.015540768,
0.0100832395,
-0.0032325878,
0.021262042,
0.010921819,
-0.0065564727,
0.015351411,
-0.021519028,
-0.035680197,
0.027943626,
-0.004916509,
-0.008108521,
0.011462838,
-0.027429659,
0.007635129,
0.0035436738,
0.008669828,
-0.0023314534,
-0.0034473047,
-0.011706296,
0.0031666514,
-0.013194098,
-0.00830464,
0.01986892,
-0.03454406,
0.026090637,
-0.034246497,
0.029296173,
-0.0076824683,
-0.007357857,
-0.0030466127,
0.03459816,
-0.00615409,
0.0067762616,
-0.020220581,
-0.0057652327,
-0.009231135,
-0.0011327583,
-0.011564279,
-0.0063434467,
0.003655259,
-0.016866265,
-0.0020727788,
-0.0036315895,
-0.01472924,
0.042010117,
-0.023412593,
-0.009562509,
-0.0071955514,
-0.01631172,
-0.005528537,
0.017894201,
0.034760464,
0.0022452285,
0.021654282,
0.014174695,
-0.004067786,
-0.025698397,
-0.014648086,
0.027240302,
-0.018029455,
-0.006018835,
0.0049097463,
0.015838329,
0.007209077,
0.005731419,
0.0080544185,
0.026604604,
-0.036464673,
-0.0055150115,
0.020288208,
-0.015202631,
-0.00887271,
0.00013736809,
0.046013657,
0.00664777,
-0.003665403,
0.00647532,
0.021992419,
-0.010631021,
-0.030973332,
0.025671346,
0.023791306,
0.012051196,
0.016230566,
-0.007310518,
-0.024805717,
0.0007996936,
0.022398183,
0.006336684,
-0.003173414,
0.007256416,
-0.009548984,
0.014959172,
0.032677542,
0.0058869617,
0.006485464,
0.0067796432,
0.01831349,
-0.038168885,
-0.0016408089,
0.015419039,
-0.033948936,
0.0022283215,
-0.0121999765,
-0.007209077,
-0.012504299,
-0.0116657205,
-0.01663633,
-0.010982684,
-0.019192645,
-0.011875365,
-0.020937432,
0.014025915,
0.008987676,
-0.0062859636,
-0.041415,
-0.023047404,
-0.003885192,
-0.01201062,
-0.037357356,
0.020923907,
-0.018949186,
-0.0386558,
0.014052966,
0.038439393,
0.018895086,
0.010908294,
0.0029248835,
-0.025644297,
0.016785111,
-0.023656052,
0.004182752,
-0.018394643,
-0.027619015,
-0.010901531,
0.017894201,
-0.00921761,
-0.009562509,
-0.008696879,
0.0036349706,
0.011861839,
0.0036349706,
0.012030908,
-0.014593985,
-0.008487234,
0.029566683,
0.011280244,
0.026780436,
0.008338454,
-0.0003381368,
-0.00795974,
-0.021951841,
-0.009488119,
-0.006843889,
-0.0050855777,
-0.0038649037,
-0.0020896855,
-0.008466946,
-0.012795097,
0.003195393,
0.0030787357,
-0.022898626,
-0.009183796,
0.012923589,
0.028322339,
0.027659591,
-0.017096197,
0.018868035,
-0.01015763,
0.0068675587,
-0.0076824683,
-0.043092154,
0.014566934,
0.006799931,
-0.026983317,
0.011915942,
0.0013702995,
-0.019855393,
-0.014052966,
0.0030043456,
-0.017610164,
0.02407534,
-0.011212617,
0.0033999656,
-0.00864954,
-0.019111494,
-0.0016915294,
-0.019909495,
0.011158515,
-0.013079132,
0.00007845831,
-0.0026137976,
-0.0006285118,
-0.023101507,
-0.02118089,
-0.023331441,
-0.008899761,
0.036789287,
0.015527243,
0.013836558,
-0.0058294786,
-0.01547314,
-0.01819176,
-0.0048826956,
-0.009474593,
-0.01947668,
-0.002226631,
0.0010287813,
0.0400895,
0.023236763,
0.031460248,
0.0106174955,
0.0056265965,
0.017840099,
0.015513717,
-0.0020558718,
0.006384023,
0.02261459,
-0.013119709,
0.014499307,
0.02419707,
-0.0048928396,
0.005751707,
0.009210846,
0.026090637,
0.026104162,
-0.013586337,
-0.028646952,
0.019138543,
-0.04717685,
-0.01275452,
-0.012321706,
-0.01771837,
-0.0087915575,
-0.02646935,
0.0018225574,
-0.018367592,
0.0037634626,
0.011327583,
-0.0006137183,
0.036735184,
0.006752592,
0.0057855207,
-0.002044037,
-0.013383455,
-0.012172925,
-0.0100156125,
-0.017015044,
0.021816587,
0.03384073,
-0.009576035,
-0.0035335296,
0.007161738,
-0.0060932254,
-0.0029130487,
0.017366707,
-0.023574898,
0.001428628,
-0.017691318,
-0.005427096,
0.0015528933,
-0.017907726,
-0.004811687,
-0.021546077,
-0.013863609,
0.010164392,
-0.014702189,
0.008034131,
-0.01067836,
-0.0018665153,
0.044228297,
-0.01475629,
0.04173961,
0.004503982,
0.020626346,
0.031676657,
0.0022841142,
-0.03838529,
-0.0107730385,
-0.011800975,
0.0015342957,
0.01992302,
0.030756924,
-0.020802177,
-0.010319935,
-0.0152973095,
0.0049401787,
-0.02318266,
-0.0428487,
0.0016932201,
-0.028160034,
0.02058577,
-0.027537862,
0.0064617945,
-0.018097082,
0.044985723,
-0.0066071935,
0.037438508,
-0.0016340462,
0.0049638483,
-0.012179688,
-0.0016196753,
-0.0064043114,
0.026185315,
-0.0047271526,
-0.003472665,
-0.015080902,
-0.021992419,
0.00037131648,
0.0009924315,
-0.005183637,
0.046744034,
-0.04268639,
-0.0052580275,
0.025211481,
0.015892431,
-0.008216725,
-0.0010203278,
0.009657187,
0.03576135,
-0.03719505,
-0.008730693,
-0.0072902297,
0.0046290928,
-0.007310518,
0.0065598544,
-0.007209077,
-0.009467831,
-0.025766024,
-0.0005591938,
0.023006829,
0.015202631,
0.014702189,
-0.03806068,
-0.014066491,
0.0037127421,
-0.041225642,
0.011084124,
0.010360512,
-0.04317331,
-0.012402859,
-0.0046831947,
0.0056874612,
0.016920365,
0.0016492623,
0.0034405421,
-0.014418154,
0.0328669,
-0.022060046,
0.0011707987,
0.017069146,
-0.009535458,
-0.024683988,
-0.00028403493,
-0.015797751,
-0.021816587,
0.019003289,
-0.010908294,
-0.032136522,
-0.0010668216,
0.021370247,
0.020355836,
0.020775126,
-0.012193213,
0.010022375,
0.018259387,
0.02587423,
0.005410189,
-0.03408419,
0.0057550888,
-0.025373787,
-0.00010508658,
0.00052960677,
-0.009055303,
-0.007384908,
0.0081220465,
-0.01663633,
0.017650742,
-0.022262927,
-0.0078988755,
-0.004764348,
-0.013714829,
-0.010725699,
0.018597525,
-0.009332576,
-0.028538747,
-0.014120594,
0.00057229656,
-0.023087982,
-0.011942992,
-0.030811027,
0.00047508223,
-0.00044380457,
0.009379915,
-0.015040325,
-0.004659525,
0.0072969925,
-0.025617246,
-0.039305024,
0.011530465,
0.004179371,
0.03516623,
0.0018986382,
-0.014675138,
-0.008372268,
-0.00031150854,
-0.04541854,
-0.021289093,
-0.008784794,
-0.010360512,
-0.00018238254,
0.012781572,
-0.01831349,
0.0019239985,
-0.013457845,
0.014566934,
-0.0075539765,
-0.033353817,
0.0054507656,
-0.006688346,
0.021383772,
0.024981547,
-0.011550753,
0.023128558,
-0.0026611367,
0.0037431745,
-0.021857163,
0.018137658,
0.0000938858,
0.02404829,
0.007175263,
0.01547314,
0.016325245,
0.026753385,
0.009251423,
-0.02414297,
0.0063535906,
0.0060932254,
-0.015080902,
-0.022289978,
0.010563394,
-0.020734549,
0.002745671,
-0.0024717802,
0.002006842,
-0.04325446,
0.0028318958,
-0.03776312,
0.020234106,
-0.0064245993,
0.005224214,
0.003739793,
0.00018069186,
0.0043585836,
-0.017380232,
-0.008284352,
-0.021951841,
-0.0074728234,
0.011138227,
-0.013092658,
-0.013971813,
0.010482241,
0.0014252467,
-0.02542789,
0.011658957,
0.010110291,
-0.0039054803,
-0.022776896,
0.011280244,
0.0027963915,
-0.012274366,
-0.021708384,
-0.0054237144,
-0.009846544,
0.023994189,
0.0047913985,
-0.016731009,
-0.0035166228,
0.0036586404,
-0.0028640188,
-0.016230566,
0.0070941104,
-0.0060391235,
-0.005812572,
-0.028836308,
0.024873344,
0.20699383,
-0.0075742644,
0.010090003,
0.03348907,
0.0024785427,
-0.02303388,
0.023047404,
0.0059444453,
-0.005843004,
-0.005599546,
0.0039967773,
-0.0015613467,
-0.018665152,
-0.008568387,
0.041333843,
-0.013390218,
-0.016000634,
0.0008550635,
-0.027105046,
0.021532552,
0.017880674,
-0.0039900145,
-0.0037972764,
-0.007824486,
0.036194164,
-0.012903301,
-0.039061565,
0.0039088614,
-0.039332073,
0.02234408,
-0.0300536,
0.008426369,
0.020666922,
-0.0077298074,
0.001166572,
-0.0013026721,
-0.001959503,
-0.0034929533,
-0.010245546,
0.0048455005,
0.00931905,
-0.020274684,
-0.015824802,
0.006897991,
-0.01786715,
-0.010705411,
0.018502846,
0.0047880174,
-0.015270258,
0.015486666,
-0.021776011,
-0.0043653464,
-0.0030060362,
0.02174896,
0.011834788,
-0.01253135,
0.015892431,
0.0008985986,
0.0081220465,
0.014080017,
-0.027199725,
0.017393759,
-0.02805183,
0.0080544185,
-0.027727218,
0.033894833,
-0.00082801253,
-0.008203199,
0.03183896,
-0.017136773,
0.023493746,
-0.0078041977,
-0.012118824,
0.010191443,
-0.02315561,
-0.012795097,
0.026036534,
0.014972698,
0.019382002,
0.03719505,
0.0050957217,
0.008088233,
-0.031352047,
0.0010431521,
-0.0056096897,
-0.014593985,
0.015757175,
-0.014201746,
-0.01917912,
0.0022976396,
0.011658957,
0.021667806,
-0.00566041,
0.0024650174,
0.008967388,
-0.023683103,
0.0017059002,
0.008805082,
-0.01035375,
-0.0016619425,
-0.022560488,
0.049665537,
0.003450686,
0.0047981613,
-0.009792442,
0.006255531,
0.015486666,
0.00533918,
0.0041996595,
-0.013998864,
0.016419923,
-0.036167115,
0.0011522012,
-0.014972698,
0.0066241003,
0.0114425495,
0.0004357738,
-0.034192394,
0.02303388,
-0.011002972,
0.011050311,
-0.0077636214,
0.025941856,
0.04574315,
0.005768614,
0.006292726,
-0.025292633,
-0.009772154,
-0.034273546,
-0.053073954,
0.0007012112,
0.0146075105,
0.014296425,
-0.0019544307,
-0.022114148,
-0.017244978,
-0.0045208894,
-0.0033627707,
-0.01804298,
0.005170112,
0.00664777,
-0.0314332,
-0.0020727788,
-0.002750743,
0.0048725517,
-0.010860954,
0.008128809,
0.024535207,
-0.0074457726,
-0.010144104,
0.018448744,
-0.005863292,
0.0137824565,
0.0172044,
0.01366749,
-0.021289093,
-0.025252057,
-0.05989079,
-0.014999749,
0.0036755472,
-0.032758694,
0.0028538748,
0.014864494,
0.009758628,
-0.008169386,
0.019517256,
-0.1713948,
0.020869805,
0.0043687276,
-0.008169386,
0.02279042,
0.028214136,
0.008162622,
-0.0005258027,
-0.02703742,
-0.002958697,
0.012051196,
0.012598977,
-0.042794596,
-0.019679563,
-0.014134118,
0.013748643,
0.021464925,
0.012098535,
0.0032275158,
0.0019611935,
-0.0060661742,
-0.015459615,
0.025887754,
0.0036687844,
0.010935345,
0.005914013,
-0.011002972,
-0.0064043114,
-0.002953625,
0.0043146256,
-0.0046764323,
0.0022232495,
0.02118089,
-0.019111494,
0.025238533,
-0.004933416,
-0.0047339154,
0.013532235,
0.000021212802,
0.041225642,
0.022979777,
0.0034557583,
0.005457528,
-0.004023828,
-0.010969158,
0.025928332,
0.00664777,
0.004970611,
0.027605489,
-0.015243207,
-0.0049570855,
-0.0025022125,
0.015040325,
0.0027490524,
0.010076477,
0.0043957788,
-0.012551638,
0.012301417,
0.00215055,
-0.012321706,
-0.0048556444,
-0.0008926812,
0.035950705,
-0.008480472,
-0.025549619,
-0.031676657,
-0.0056874612,
0.016217042,
-0.009562509,
-0.007493112,
0.007743333,
-0.019503731,
-0.0036451148,
0.00052030804,
0.027389081,
-0.0015706455,
0.013065606,
0.0042943377,
-0.024034765,
-0.012612503,
-0.025197955,
0.04068462,
-0.0071685,
-0.01986892,
-0.020301735,
0.00590725,
-0.01015763,
0.0124231465,
-0.0006352745,
0.0136472015,
0.028214136,
-0.016893316,
0.029025665,
-0.013613388,
0.045878403,
0.02632057,
0.006218336,
0.009724814,
0.003875048,
0.0050585265,
0.015053851,
-0.030134752,
-0.024007713,
0.030297058,
0.04060347,
0.016027685,
0.0015376771,
0.000993277,
0.03459816,
0.01336993,
-0.011131464,
-0.0024548732,
0.014107068,
0.012450198,
0.0005181947,
0.052559987,
-0.010867717,
-0.00080096157,
0.004392397,
-0.018813932,
0.057077494,
-0.011841551,
-0.03465226,
-0.010509293,
-0.00743901,
0.0018529898,
-0.13893366,
-0.0070873476,
0.0095692715,
0.007256416,
0.0025495517,
0.0061574713,
0.0041489387,
0.0207616,
-0.019070916,
0.037573762,
-0.02461636,
-0.013701304,
0.0003968881,
-0.0125786895,
-0.009474593,
0.017420808,
0.0047913985,
-0.015946532,
0.0053662313,
0.037303254,
0.00879832,
-0.004730534,
-0.023196185,
-0.0066274814,
0.01989597,
-0.00931905,
-0.039088614,
0.018678678,
0.020423463,
0.009711289,
0.008277589,
-0.020842753,
0.008541336,
0.013254963,
-0.03289395,
0.015973583,
-0.014445204,
-0.015391988,
0.047717866,
-0.011672483,
0.0072361277,
-0.005082196,
-0.01992302,
-0.00600531,
0.010975921,
-0.0042199474,
-0.0023382162,
0.008642777,
-0.006116895,
-0.0018935661,
-0.034111243,
-0.0066241003,
-0.032569338,
-0.0062048105,
0.03384073,
-0.0054135704,
0.008419607,
0.0010414614,
-0.011557517,
0.015905956,
-0.007411959,
-0.00039012535,
-0.022885099,
-0.0060425047,
0.024873344,
-0.00837903,
0.0035166228,
-0.007418722,
0.031406146,
0.0032241344,
-0.012883012,
0.014986224,
-0.024427004,
0.008223487,
-0.032488186,
-0.01816471,
-0.049313873,
-0.009197322,
0.004351821,
-0.012369045,
0.011334346,
-0.013417269,
0.004500601,
-0.021924792,
0.020220581,
0.0049367975,
0.00931905,
0.0012265913,
0.03454406,
-0.0013238057,
-0.008466946,
0.04068462,
0.007256416,
-0.03118974,
0.00793269,
0.023791306,
-0.019449629,
0.00575847,
0.03892631,
0.005383138,
-0.0172044,
-0.018218812,
-0.060431812,
0.033678427,
0.004389016,
-0.00090282527,
0.011070599,
-0.010597208,
0.015770702,
0.01771837,
-0.018205287,
0.01329554,
-0.019409053,
0.0015968512,
-0.037438508,
-0.024332326,
-0.020518143,
0.0041083624,
0.010833903,
-0.01245696,
0.013092658,
0.008270826,
0.011002972,
-0.024210596,
-0.008284352,
0.007175263,
-0.014999749,
0.000080148995,
-0.019057391,
0.0019409053,
-0.005748326,
-0.015459615,
0.031406146,
-0.02160018,
-0.012402859,
0.016852738,
-0.0037803696,
-0.015946532,
-0.018786881,
0.027889524,
0.0027591963,
0.0037127421,
-0.041577302,
-0.024264697,
-0.010448428,
0.0118145,
-0.012828911,
-0.0026340857,
-0.012822148,
-0.005613071,
-0.011117938,
-0.020518143,
0.042280626,
0.015838329,
0.022858048,
-0.029431429,
0.00036878046,
-0.0052039255,
-0.018178236,
-0.016690433,
0.004558084,
-0.0069318046,
0.0039054803,
-0.008960625,
0.014404628,
0.02091038,
-0.0034929533,
-0.011686008,
-0.018624576,
-0.017231451,
0.019977123,
-0.032731645,
-0.016555179,
0.014702189,
0.004503982,
-0.015243207,
-0.007026483,
0.008892998,
-0.008358742,
0.0097045265,
-0.02679396,
0.008690116,
0.011787449,
-0.017785996,
-0.019855393,
0.024061816,
0.04485047,
-0.006052649,
-0.0136472015,
0.029404378,
-0.00044000053,
-0.0010093384,
0.0014615963,
0.022411708,
-0.00016832873,
0.012484011,
-0.0050754338,
0.017542537,
-0.030432314,
-0.011036785,
0.016244093,
0.012551638,
-0.01663633,
0.009420492,
0.007317281,
-0.023412593,
-0.0052140695,
0.04552674,
-0.01798888,
-0.020491092,
0.005389901,
0.00358425,
0.017001519,
0.010340224,
0.005126154,
0.020355836,
-0.019084442,
0.00013916443,
-0.009745103,
-0.0108406665,
-0.011212617,
0.021830112,
0.010860954,
0.0011784068,
0.004950323,
-0.0050754338,
0.016325245,
-0.015229682,
0.021086212,
-0.013126471,
0.01309942,
-0.006840508,
0.017731894,
0.011104413,
-0.01080009,
-0.001819176,
0.0071887886,
0.00899444,
-0.010056189,
0.025766024,
-0.0026729715,
0.084020235,
0.032731645,
-0.020288208,
0.011523702,
-0.044904567,
0.010002087,
0.013748643,
-0.00224861,
-0.0019121637,
-0.04176666,
0.016798638,
-0.03348907,
0.040792827,
-0.014621036,
-0.014891545,
-0.007797435,
-0.021113263,
0.030513465,
-0.0030144898,
-0.008730693,
-0.004236854,
0.011584567,
-0.011287007,
-0.004886077,
-0.025170904,
-0.00064795464,
-0.0073443316,
-0.0074728234,
-0.012592215,
-0.018868035,
0.0031767953,
0.019449629,
-0.018340541,
-0.00081744575,
-0.0124231465,
0.029647836,
-0.014905071,
0.0011124702,
0.029404378,
0.0142287975,
0.0043112445,
-0.0067627365,
-0.016000634,
-0.0041455575,
-0.0010127197,
0.0100359,
0.0059816404,
0.009251423,
-0.016541652
] |
The experience accumulated in cardiac cell therapy suggests that regeneration of extensively necrotic myocardial areas is unlikely to be achieved by the sole paracrine effects of the grafted cells but rather requires the conversion of these cells into cardiomyocytes featuring the capacity to substitute for those which have been irreversibly lost. In this setting, the use of human pluripotent embryonic stem cells has a strong rationale. The experimental results obtained in animal models of myocardial infarction are encouraging. However, the switch to clinical applications still requires to address some critical issues, among which the optimization of the cardiac specification of the embryonic stem cells, | [
-0.02613982,
-0.004523692,
-0.01306991,
-0.024966035,
-0.009218837,
0.0041774916,
-0.011678512,
0.0067591616,
-0.052042246,
0.0101420395,
0.000392155,
0.008216502,
-0.009370506,
-0.010115662,
-0.006495389,
-0.0026261816,
0.038326092,
0.0009528769,
0.007029528,
0.014454714,
-0.010306897,
0.027643321,
-0.011678512,
-0.010900384,
-0.0030927286,
0.010458566,
0.021471053,
-0.011704889,
-0.0031652658,
-0.009370506,
-0.006989962,
-0.0049754023,
-0.0013922224,
-0.025915613,
-0.008849556,
-0.026495913,
0.00075463566,
-0.012535771,
0.0051765284,
0.01732983,
0.011408146,
-0.01628793,
-0.006317343,
-0.0058491477,
0.004995185,
0.001302375,
-0.010524509,
-0.024873713,
0.004886379,
0.029094068,
0.040383518,
-0.023159195,
0.0020887458,
0.011263071,
-0.030940473,
-0.030993229,
-0.024689073,
0.026271706,
0.02016538,
-0.014876749,
0.010504726,
-0.009218837,
-0.007530695,
0.006989962,
-0.000084644074,
0.0056743985,
-0.007972513,
0.0031965887,
0.008447303,
0.0018925652,
0.026825627,
0.009159488,
0.012713818,
0.012377508,
0.009040791,
-0.014362394,
-0.00790657,
-0.016076913,
0.00034640703,
0.018015638,
-0.009456231,
-0.043522406,
-0.01827941,
0.047558118,
-0.00011354567,
-0.0036763244,
-0.006317343,
0.00414452,
0.021655694,
0.011322419,
0.032892387,
0.042177167,
0.0042797034,
0.010069502,
-0.014903126,
-0.0069833677,
0.0010666286,
0.032707747,
0.007840627,
-0.019479573,
-0.011625757,
0.0009512283,
-0.020838,
-0.017356208,
-0.036321424,
-0.010399217,
0.011177345,
0.003117457,
0.040198877,
-0.0019733454,
-0.023159195,
0.040304385,
-0.020046683,
-0.016604457,
0.035846636,
-0.007088877,
0.03257586,
0.023686739,
-0.017290264,
-0.014032679,
0.022381067,
-0.006989962,
0.03534547,
-0.031520773,
0.015865894,
0.0026805846,
-0.013102882,
0.026100254,
0.0028339021,
0.0133139,
0.005865633,
0.00050281564,
-0.0075175064,
0.02745868,
-0.014059056,
0.009476014,
-0.0036433528,
-0.0065448466,
-0.01515371,
-0.024543999,
-0.012239028,
0.0012520935,
-0.0033795808,
-0.016841851,
-0.019848855,
-0.0025635357,
0.026469536,
0.015799953,
0.02642997,
0.005539215,
0.0034883867,
-0.016934171,
0.032734126,
-0.012970995,
-0.005041345,
0.005463381,
-0.00011004244,
0.012285188,
-0.028091734,
-0.0031355915,
-0.0015710929,
-0.019466385,
0.01599778,
0.007979108,
0.012786355,
0.019585082,
0.002270089,
0.006079948,
0.015496614,
-0.01647257,
-0.017488094,
0.046397522,
-0.019360876,
0.027775208,
-0.010781687,
0.0035642213,
-0.016973738,
0.023357024,
-0.036901724,
-0.027669698,
-0.031599905,
0.0145866,
0.016235176,
0.0038675591,
-0.011012487,
-0.0009240268,
0.025031976,
-0.018173901,
0.0014754755,
-0.013795284,
-0.010544292,
0.014336016,
0.0007035298,
0.0036928102,
-0.6381176,
-0.015430671,
0.015747197,
-0.0017194647,
0.01506139,
0.022130484,
0.015298785,
-0.023647174,
-0.011177345,
0.007728524,
-0.019677402,
-0.00037422674,
0.017633168,
-0.016736344,
-0.010926762,
-0.0109069785,
-0.005034751,
-0.0041972743,
0.017356208,
0.00842752,
-0.014059056,
-0.004625904,
-0.022024974,
0.025467202,
-0.0039961482,
0.018068392,
0.0166704,
0.007623015,
-0.018543182,
0.027432304,
-0.0068316986,
0.011269665,
-0.018437674,
-0.019677402,
0.046186503,
0.022565708,
-0.0089484705,
0.012944618,
-0.012905053,
0.032048315,
0.00079955935,
0.008974847,
0.033077028,
-0.0035312497,
-0.022341501,
0.0104058115,
0.009113328,
-0.00051476783,
-0.026825627,
0.007418592,
-0.0023574636,
0.0068910476,
-0.018411295,
0.016248364,
0.018411295,
0.003973068,
0.031336132,
-0.004909459,
-0.0017837592,
-0.008994631,
0.01742215,
0.019176235,
-0.019545516,
-0.030465683,
0.0073922146,
0.012067576,
-0.004137926,
0.004616013,
0.003778536,
-0.022789914,
0.007972513,
0.021655694,
-0.00262783,
-0.0017079246,
-0.010748715,
0.009535363,
-0.0068778587,
-0.0050941,
-0.00851984,
0.013340277,
-0.0011836776,
-0.014309639,
-0.009060574,
0.017725488,
0.018464051,
0.009469421,
-0.016261553,
0.031309754,
0.01103227,
0.016142856,
-0.012403886,
0.008407737,
-0.00008000745,
-0.06472968,
-0.016525324,
0.018094769,
-0.011751049,
0.0036961073,
0.0017194647,
-0.0037027015,
0.0043720235,
0.023251515,
0.02111496,
0.0150877675,
-0.00025264427,
-0.004035714,
-0.045500696,
-0.018701445,
0.04916713,
-0.05114542,
-0.010076096,
-0.014837184,
0.0032411003,
-0.00082882156,
-0.00054938794,
-0.027696077,
-0.014903126,
0.0071548196,
-0.012324754,
-0.027907094,
0.027827961,
-0.04130672,
0.0022849264,
0.0063470174,
0.01070915,
0.0041181426,
-0.00042574474,
-0.008546217,
0.024570376,
-0.010445377,
-0.002204146,
-0.020508286,
0.025058355,
-0.021668883,
0.017685922,
0.0124830175,
0.02719491,
0.010419,
0.012562148,
-0.0023723007,
0.000572468,
0.00021369665,
0.01696055,
-0.010880602,
-0.015035013,
0.006149188,
-0.006541549,
-0.013003967,
-0.02339659,
-0.00091743254,
-0.020666549,
-0.013261145,
-0.0033383663,
0.015602123,
0.017870564,
-0.012700629,
-0.007682364,
-0.0401725,
-0.003005354,
-0.030070025,
-0.00314878,
0.045527074,
-0.014415148,
0.02679925,
-0.012753383,
-0.022618461,
-0.004616013,
0.0023673552,
-0.0032015345,
-0.022776725,
-0.0023706523,
-0.009357317,
0.0023854894,
0.013755717,
-0.014032679,
0.013399625,
-0.013742529,
-0.012028011,
-0.02793347,
0.008671509,
-0.008981442,
-0.04014612,
0.0097134095,
0.01611648,
-0.0064690122,
0.009166082,
0.026456347,
0.0032312088,
-0.00062274956,
0.027432304,
0.011091619,
0.0030993228,
-0.018384919,
0.022473387,
0.026957514,
-0.021431487,
-0.012845703,
-0.004846813,
0.0077812783,
0.020917132,
0.008110994,
-0.013353465,
0.018912463,
-0.0066371667,
-0.00083253084,
-0.019215802,
0.0002959194,
-0.0069767735,
0.021721637,
0.008269257,
-0.008638538,
0.0152328415,
-0.012153302,
-0.02140511,
0.0061755655,
0.0096408725,
0.017105624,
-0.013993112,
-0.004922648,
0.011830181,
0.009963993,
-0.004886379,
-0.0006520118,
-0.004161006,
0.0011770832,
0.017923318,
0.00023224314,
0.018160712,
-0.010880602,
-0.007965919,
0.006449229,
0.017184755,
0.02719491,
0.010880602,
0.008387954,
0.010412405,
0.0044181836,
-0.009100139,
0.02851377,
0.016841851,
-0.0036664328,
0.021721637,
-0.023581231,
0.00045006123,
-0.0056513185,
-0.0028948993,
0.02482096,
0.032734126,
-0.009146299,
0.02785434,
-0.022051351,
0.01334687,
-0.023225138,
0.0060667596,
0.0026344245,
-0.024570376,
-0.0066932184,
0.004863299,
0.044841267,
0.017382585,
0.009086951,
-0.004454452,
0.020613793,
-0.024504432,
0.002449784,
0.007590044,
0.028355507,
-0.006403069,
-0.008915499,
0.008420926,
-0.014151376,
0.004770979,
0.00838136,
-0.04339052,
0.0014622869,
0.01340622,
0.025823293,
-0.0032823146,
-0.0015620257,
0.0029460052,
-0.014322828,
-0.015272408,
0.0073394603,
0.011394957,
-0.0061557824,
0.0036598386,
-0.027907094,
-0.009495798,
-0.0212996,
0.024161529,
0.007899976,
-0.012212651,
0.015470237,
0.008750641,
-0.0005988452,
-0.03494981,
0.0076098265,
0.00063181674,
0.036743462,
-0.016063724,
0.014547034,
-0.0011399903,
-0.0133204935,
-0.026772873,
0.04222992,
0.02065336,
0.005664507,
0.0030778912,
0.00039050644,
-0.004586338,
-0.015654877,
-0.00985189,
0.0070163393,
-0.024873713,
-0.0075636664,
0.010814658,
0.0019354281,
0.021629317,
0.017263887,
0.006139297,
-0.0025256183,
-0.023713116,
0.0046094186,
-0.029516105,
0.037930436,
0.023027308,
0.0085660005,
0.014810806,
-0.0020854485,
-0.0025124298,
0.0030877828,
-0.031969186,
0.01818709,
-0.0022766835,
0.024939656,
-0.0009982127,
0.008348389,
-0.016802287,
0.007596638,
0.025045166,
-0.018846521,
-0.0012059333,
-0.0150877675,
-0.02670693,
0.006640464,
-0.006643761,
0.024781393,
0.034817923,
0.014309639,
0.010043125,
0.03465966,
0.0037191873,
-0.0104058115,
-0.008308823,
-0.010399217,
0.0142041305,
0.002103583,
-0.0027762018,
-0.0044412636,
-0.021813957,
0.0024992411,
0.017738678,
0.021088583,
0.00527874,
0.009858484,
0.024372546,
-0.000059863913,
0.0033119891,
0.00828904,
-0.018055204,
0.00030333796,
0.0022024976,
-0.0005011671,
-0.04151774,
0.031731788,
-0.016920984,
-0.027221287,
-0.024214283,
0.007847222,
-0.012245622,
-0.015562557,
0.002449784,
0.0007418592,
0.021906277,
0.002227226,
-0.037191875,
0.003300449,
-0.0015842814,
-0.01618242,
-0.007379026,
-0.02151062,
0.0012990779,
-0.032496728,
0.0013056721,
0.0039400966,
-0.012740195,
-0.028619278,
0.009225431,
0.0012776464,
0.014283262,
0.016894607,
-0.0214183,
0.00017814923,
0.020983074,
0.022473387,
-0.022394255,
-0.0067228926,
-0.007379026,
-0.011131185,
-0.01686823,
-0.031336132,
-0.030360175,
0.0051534483,
0.009225431,
0.03777217,
-0.010498132,
-0.01638025,
0.00622832,
-0.009363911,
0.020521473,
0.018965218,
-0.002449784,
0.004507207,
-0.018160712,
-0.02073249,
-0.018358542,
0.00097101124,
-0.024596753,
-0.0008778667,
-0.009027602,
-0.011929096,
0.018213468,
0.00686467,
-0.0035708155,
0.024675885,
-0.0076691755,
0.018398108,
-0.0009809027,
0.012390696,
0.02102264,
0.006442635,
0.012443451,
0.0135842655,
-0.005057831,
-0.0062777773,
-0.008051645,
0.04602824,
-0.006248103,
-0.016644023,
-0.00809121,
0.0022849264,
-0.012060981,
-0.051461946,
0.015760386,
-0.011784021,
0.021932654,
-0.0010344815,
-0.015945027,
-0.038115077,
-0.018042015,
0.004892973,
0.024715452,
0.023620795,
-0.020046683,
-0.0014589897,
0.014982258,
-0.010874007,
-0.01970378,
0.026575044,
-0.037561156,
-0.008025268,
0.019822476,
0.017263887,
-0.01601097,
-0.018015638,
0.0046654698,
-0.015325162,
-0.009390289,
-0.032048315,
-0.035002563,
-0.011876341,
-0.021734824,
0.032628614,
0.03041293,
0.03260224,
-0.0059546563,
0.0032493433,
0.0071943854,
-0.003082837,
0.0055458094,
0.0011713132,
0.016604457,
-0.024451679,
0.050934404,
-0.00876383,
-0.007082282,
0.011718078,
-0.023264704,
0.0051501514,
0.019756535,
-0.0050973967,
-0.017580414,
0.006201943,
-0.021813957,
-0.022750348,
0.008361577,
-0.015562557,
-0.00030725333,
-0.03400023,
-0.009970588,
0.024900092,
-0.007880193,
0.004081874,
0.004494018,
0.02690476,
-0.015219653,
0.000103602695,
-0.016749531,
0.0011350445,
-0.004022525,
-0.025440823,
-0.009264997,
-0.0092584025,
0.0075438838,
0.02679925,
-0.00828904,
0.018727822,
-0.020389587,
-0.0077417125,
0.011784021,
-0.038959146,
-0.018147524,
-0.009396883,
-0.031309754,
-0.006472309,
-0.008176937,
-0.021853523,
-0.015958216,
-0.0024201095,
0.009687033,
-0.028302751,
0.014098622,
-0.011559814,
0.014006301,
0.008915499,
-0.016419817,
0.013426002,
-0.0026113442,
0.007550478,
0.025691407,
-0.012370914,
-0.02112815,
-0.015074578,
0.00364665,
0.0031735087,
0.027485058,
0.0031982374,
-0.0065613324,
-0.02613982,
0.014850372,
0.02613982,
-0.029225955,
-0.011975256,
0.013043533,
0.007510912,
-0.0048665963,
-0.008777019,
-0.012601715,
-0.030070025,
-0.008598972,
0.003913719,
-0.00020998737,
0.012014821,
-0.014401959,
-0.031573527,
0.024781393,
0.00828904,
0.010636612,
0.009627683,
-0.013076505,
-0.015522991,
-0.019954363,
-0.020903943,
0.018675068,
-0.0034389293,
0.004424778,
-0.010300303,
-0.011210317,
0.022723971,
-0.007899976,
0.022697594,
0.0027316904,
0.009469421,
0.038510732,
0.0055589983,
0.013716152,
0.016169233,
-0.0035279526,
0.011559814,
-0.022684405,
-0.013096287,
-0.0059975195,
-0.037376516,
-0.01951914,
0.03107236,
0.023686739,
0.013834849,
-0.0024942954,
-0.01780462,
-0.017369397,
-0.013650209,
-0.02197222,
-0.00027119074,
-0.024781393,
-0.0058986046,
-0.014006301,
0.02434617,
0.0068316986,
-0.023686739,
0.008770424,
-0.000117358,
0.0131292585,
0.0031355915,
0.0127467895,
0.012661063,
0.0043258634,
-0.0042961887,
-0.007398809,
-0.0066536525,
-0.0053216033,
-0.02027089,
-0.014415148,
-0.02727404,
-0.014217319,
-0.021655694,
0.02075887,
-0.01705287,
0.0007665878,
0.01611648,
0.016749531,
0.008407737,
0.027142154,
-0.022882234,
0.0056117526,
-0.018714635,
-0.011348797,
0.017171567,
-0.025229806,
-0.01302375,
-0.034554154,
-0.009284779,
0.008031862,
-0.018160712,
-0.013676586,
-0.008592377,
0.0081044,
-0.029252332,
-0.022803102,
-0.008631944,
-0.007095471,
-0.018978406,
0.013122665,
0.008862744,
-0.014441526,
-0.023752682,
0.01055748,
0.009680438,
0.023686739,
-0.012430263,
0.021853523,
-0.00674927,
-0.03373646,
-0.009297969,
-0.0038675591,
-0.02036321,
0.031204246,
0.011968661,
-0.0025404554,
-0.021853523,
0.0046094186,
-0.08440709,
-0.023752682,
-0.0057205586,
0.0339211,
0.020046683,
0.02660142,
-0.012166491,
0.00023162492,
-0.0066239783,
0.014982258,
-0.0037257816,
-0.02301412,
0.028197244,
-0.01336006,
0.019070726,
0.011091619,
-0.04404995,
-0.0137029635,
0.042203546,
-0.0028141192,
0.0069108303,
0.00809121,
-0.015166899,
0.040990192,
-0.005516135,
0.011988444,
0.008143965,
0.026548667,
0.021668883,
-0.0452633,
-0.008961659,
0.027827961,
-0.011111402,
-0.01264128,
-0.0006573697,
0.0035873014,
0.0033152862,
0.0022832777,
-0.017263887,
-0.036901724,
-0.0072867055,
-0.016169233,
0.015114144,
0.0047050356,
-0.017066058,
0.024227472,
0.010636612,
0.0101882,
-0.018042015,
0.004276406,
0.0013881009,
-0.00069363834,
0.002876765,
-0.0036268672,
-0.011454306,
0.005473272,
0.00087951525,
-0.016920984,
-0.020811623,
0.029885385,
0.0033218805,
0.009284779,
0.024267038,
0.0068778587,
-0.014837184,
-0.0031866974,
0.019756535,
-0.015391105,
-0.014190942,
-0.017672734,
0.012535771,
0.0037719419,
-0.013610643,
-0.00031467192,
0.0043522404,
-0.019769723,
0.01988842,
-0.00570737,
-0.0093309395,
0.012680846,
0.19782911,
-0.033499062,
-0.009100139,
-0.011085025,
0.006989962,
-0.007510912,
-0.009014414,
-0.007939542,
-0.024319792,
0.0018299193,
0.013676586,
0.00103036,
-0.013887604,
-0.018477239,
0.018239845,
-0.024214283,
-0.016604457,
-0.010669583,
-0.0014218967,
-0.01544386,
-0.0075834496,
-0.012159896,
0.029753499,
0.0007220763,
0.011955473,
-0.020666549,
-0.017870564,
0.01999393,
0.023436155,
0.019505952,
-0.015760386,
-0.0023211949,
0.0072009796,
0.016459383,
0.029094068,
-0.000466547,
0.004583041,
0.0063008573,
0.008486869,
-0.013768907,
-0.0012661064,
0.008691292,
-0.006858076,
0.007530695,
0.0051369625,
0.04784827,
-0.016986927,
0.0005629887,
0.02131279,
-0.0074845348,
-0.045342434,
-0.006989962,
0.025177052,
0.01515371,
0.01696055,
-0.00007686485,
0.0137029635,
0.013887604,
0.011322419,
0.018028827,
-0.019769723,
-0.004576447,
-0.013214985,
0.039433938,
-0.025691407,
0.02339659,
0.0048303274,
0.0035477355,
0.0127467895,
-0.005229283,
-0.0035015752,
-0.010419,
-0.034633283,
0.00511718,
-0.010781687,
-0.020969886,
0.015668066,
0.015879083,
0.005318306,
0.0030581085,
0.021378733,
-0.015694443,
-0.022948178,
-0.012832515,
-0.0018958624,
-0.045025907,
0.014573411,
0.011401551,
-0.019400442,
-0.010300303,
0.005361169,
-0.0026525587,
-0.018213468,
-0.012542366,
0.041728754,
0.0109795155,
0.018160712,
0.015971404,
0.004662173,
-0.0008308823,
-0.018477239,
0.07100746,
0.0051336656,
-0.009139705,
-0.01008269,
0.014533846,
-0.0035938956,
0.016512137,
-0.016024157,
0.011355391,
0.011388362,
-0.018015638,
-0.0015587285,
-0.00077524286,
0.0036763244,
0.033367176,
0.042572826,
-0.022671217,
0.046925064,
-0.023080064,
0.0037851303,
-0.004777573,
-0.0041873828,
0.0324176,
-0.010623423,
-0.01599778,
-0.0069174245,
0.018635502,
-0.00842752,
-0.025427636,
-0.026192574,
0.000093041504,
-0.0023953808,
0.01639344,
0.019927986,
0.01155322,
0.017738678,
0.011691701,
-0.0098782675,
0.014059056,
0.0034356322,
-0.0027234475,
-0.0024695669,
0.018384919,
0.0040060394,
-0.0077417125,
0.016894607,
0.022816291,
-0.008354983,
-0.019822476,
0.0011268017,
-0.019374065,
-0.012924835,
-0.017791431,
0.026298083,
0.0028339021,
-0.014863561,
-0.027616944,
-0.0026014529,
-0.011573004,
-0.017158378,
0.021906277,
0.016327497,
-0.029410595,
-0.0072471397,
-0.009838701,
-0.16480485,
0.0059810337,
0.025084732,
-0.015483425,
0.05125093,
0.0031586715,
-0.005793096,
0.0030811885,
-0.012423668,
0.005826067,
0.02756419,
0.0011960418,
-0.036532443,
-0.027142154,
0.006096434,
-0.005855742,
-0.0045335838,
0.041570492,
0.024121962,
0.0096408725,
0.014612977,
-0.0090671675,
0.02075887,
-0.016525324,
0.007590044,
-0.017514471,
-0.0002738697,
-0.016920984,
-0.004362132,
-0.020310456,
-0.019189425,
-0.0002369828,
0.03592577,
-0.012324754,
-0.014283262,
-0.0051666372,
0.010293708,
-0.006643761,
0.00795273,
0.029911762,
0.014270074,
0.0039367992,
-0.018648691,
-0.018965218,
-0.022024974,
0.009548552,
-0.0145866,
-0.027722454,
0.009924428,
0.006752567,
0.009983776,
-0.008223097,
-0.020429153,
0.021721637,
0.007451563,
0.029199578,
0.030571193,
-0.014533846,
-0.010227765,
0.008256068,
-0.0034653067,
0.014045867,
0.024108775,
0.011269665,
0.015549368,
-0.039064657,
0.005832662,
-0.009561741,
-0.020415965,
0.0056776954,
-0.03571475,
-0.00989805,
0.012529178,
-0.012377508,
0.050828893,
0.0016065373,
-0.015206465,
0.0094496375,
0.0025404554,
0.013274333,
-0.015048201,
0.027300417,
-0.013755717,
-0.017765054,
0.0022981148,
0.011869747,
0.022024974,
-0.012271999,
-0.012166491,
-0.007946136,
0.012872081,
-0.04083193,
0.013610643,
-0.013168825,
0.02082481,
0.013861227,
-0.009555146,
-0.017923318,
0.0039862567,
0.014560223,
0.04576447,
0.0024827553,
-0.009113328,
-0.0024036237,
0.05169934,
-0.00039833717,
-0.039249297,
0.0077878726,
0.052543413,
-0.016446194,
-0.004995185,
-0.0066965157,
-0.0040192283,
0.04993207,
-0.016367063,
0.02244701,
0.0029905168,
-0.0085660005,
0.005268849,
-0.024794582,
0.05438982,
0.00534798,
-0.021616127,
0.03534547,
0.00842752,
-0.015114144,
-0.14085433,
-0.012232434,
-0.0020030197,
0.032338466,
-0.010656395,
0.007774684,
-0.004322566,
0.013557889,
-0.010999299,
0.03421125,
-0.014362394,
-0.02253933,
0.014388771,
-0.0060700565,
0.03220658,
-0.0011696647,
-0.013307305,
0.011441117,
-0.024214283,
0.030201912,
-0.013650209,
-0.0046720644,
-0.012647875,
-0.008143965,
0.012727006,
0.03429038,
-0.016235176,
0.029859008,
0.029384218,
0.01913667,
0.030201912,
0.001932131,
0.029225955,
-0.0021827146,
-0.0321802,
-0.00419068,
-0.009410071,
-0.025493579,
0.019782912,
-0.022961365,
-0.0066602468,
0.015219653,
0.014415148,
-0.017844185,
0.0093309395,
-0.005275443,
-0.030914096,
-0.008143965,
-0.00011117584,
-0.020231323,
-0.03998786,
-0.015879083,
-0.007946136,
0.02615301,
0.01961146,
-0.010860818,
0.009957398,
0.0006598425,
-0.0038312904,
-0.023976889,
-0.022196427,
-0.014863561,
-0.0038972336,
-0.007636204,
0.04130672,
-0.018833332,
-0.032048315,
-0.032813255,
0.007029528,
-0.0229218,
-0.0001531115,
0.0028190648,
-0.011394957,
-0.0020969885,
-0.013056722,
0.0043093776,
0.004114846,
-0.017158378,
-0.008783612,
0.0010386029,
-0.025506767,
-0.019571893,
0.017369397,
0.0029476539,
0.0085660005,
0.0012084062,
0.016446194,
-0.023198761,
0.0056117526,
-0.0061129197,
-0.008803396,
0.03257586,
-0.0023146006,
-0.031204246,
0.0077549014,
0.0060008164,
-0.01581314,
0.0064459317,
0.011190534,
0.019479573,
-0.011573004,
-0.025414446,
-0.03410574,
0.02869841,
-0.014072244,
-0.0005996695,
-0.0032757204,
-0.016327497,
0.024834149,
-0.00033445485,
0.01638025,
-0.01046516,
-0.015100956,
-0.00011519424,
-0.0036631357,
0.0020112626,
-0.021101773,
-0.0013765609,
0.008994631,
0.0012669306,
-0.003930205,
0.01648576,
-0.0036565415,
-0.0043984004,
-0.0019716967,
0.015984593,
0.0035048726,
-0.008414332,
-0.018094769,
0.022143671,
0.0022981148,
-0.023027308,
0.007365837,
-0.039011903,
-0.01581314,
-0.0050908024,
0.0016510488,
0.004015931,
0.011955473,
0.031045983,
0.010069502,
0.042124413,
-0.010788281,
-0.013610643,
0.0108344415,
0.014823995,
0.0016592917,
0.012918241,
-0.028434638,
0.0255859,
0.013426002,
-0.021049017,
0.020284079,
0.0106498,
-0.015509803,
-0.029278709,
-0.02519024,
-0.0078010615,
0.007379026,
0.006904236,
0.0023327349,
-0.010155228,
0.009489203,
-0.011652134,
0.008414332,
-0.00772193,
0.0019469681,
-0.011823587,
-0.011269665,
0.0025767242,
0.015509803,
-0.015654877,
-0.016512137,
0.018266222,
0.00772193,
-0.008770424,
-0.004599527,
0.0031092141,
-0.018464051,
0.019835666,
0.0019651025,
0.020231323,
0.006073354,
-0.0092584025,
-0.024834149,
-0.009739786,
0.011025676,
0.007088877,
-0.00668003,
0.028249998,
0.008783612,
-0.00016763956,
0.0214183,
0.01913667,
-0.007972513,
0.024596753,
-0.0003237391,
0.023818625,
-0.032101072,
-0.00059637235,
0.0013468865,
0.027537813,
-0.010069502,
0.024319792,
0.020257702,
-0.0074713463,
-0.017606791,
0.009034196,
-0.033367176,
-0.021062206,
-0.025783727,
-0.0062909657,
0.0044379663,
0.017989261,
0.0041741943,
0.0029344652,
-0.022869045,
0.016644023,
0.018859709,
-0.021959031,
-0.017962884,
0.04803291,
0.001084763,
0.010346463,
-0.0016980332,
0.014639354,
0.01618242,
0.021075396,
0.031045983,
0.0026228842,
0.026456347,
0.01334687,
0.039064657,
0.008895716,
-0.0063470174,
-0.015311973,
0.008737452,
-0.0327605,
-0.00041235005,
0.01245664,
-0.0074713463,
0.05103991,
0.007550478,
-0.023792248,
0.0034158493,
-0.00262783,
0.030149156,
0.003887342,
0.024385735,
-0.033841968,
-0.03371008,
0.017844185,
-0.028619278,
0.030544816,
-0.03666433,
-0.024992412,
0.022948178,
-0.014678921,
0.016037347,
0.006950396,
0.00060502737,
0.0046588755,
-0.0049193506,
0.001090533,
0.013003967,
-0.025493579,
-0.019387253,
0.022803102,
-0.009495798,
0.00021513917,
0.012621498,
0.009654061,
0.0037290787,
-0.044656627,
0.009317751,
0.006963585,
0.0019535625,
-0.005298523,
-0.025836483,
0.004078577,
0.009746381,
-0.030439306,
0.021748014,
-0.030360175,
-0.02727404,
-0.014270074,
-0.015522991,
-0.012080764,
-0.0022057947,
-0.029859008
] |
OBJECTIVE To compare pregnancy rates (PR) for letrozole and gonadotropins in individuals who failed to conceive with clomiphene citrate (CC). DESIGN Retrospective cohort study. SETTING University reproductive center. PATIENT(S) Individuals treated with letrozole or gonadotropins who failed to conceive with CC. INTERVENTION(S) Controlled ovarian hyperstimulation (COH), transvaginal ultrasound, ovulation induction, IUI. MAIN OUTCOME MEASURE(S) Pregnancy rates per cycle. RESULT(S) Among patients who failed to conceive with at least three cycles of CC, gon | [
-0.04836545,
0.0039981664,
0.0045826933,
-0.02168429,
0.026106656,
0.013400705,
0.01867815,
0.0057884897,
-0.042406615,
-0.031450905,
-0.0009970365,
0.029366648,
0.0046695373,
-0.0016007696,
-0.0024199428,
0.023501335,
0.03500483,
-0.0015181007,
0.007234777,
-0.015418158,
-0.015725452,
-0.016072828,
-0.024636988,
-0.0010613344,
0.015324634,
-0.042673826,
0.021296833,
-0.02638723,
0.008403831,
0.021617487,
-0.01438939,
0.017061515,
-0.0057216864,
-0.020214621,
-0.043475464,
-0.043021206,
-0.0045726732,
0.0071746544,
0.015204389,
-0.0043455423,
0.02577264,
0.005260745,
0.0026086615,
0.015044061,
0.00039831357,
0.00048348753,
0.0057851495,
-0.014857012,
-0.024449939,
0.008884814,
-0.01865143,
0.005561359,
-0.01674086,
0.025411904,
0.0024366435,
-0.013674597,
-0.019038888,
0.029446812,
0.0048432257,
-0.038719084,
-0.009058502,
0.0066001476,
-0.024623627,
0.032252543,
-0.009205469,
0.019038888,
-0.0041918955,
-0.005097077,
-0.0042353175,
0.015952583,
0.03455057,
0.022272158,
-0.009566206,
0.007361703,
0.020455113,
-0.019626753,
-0.030221729,
-0.0072414572,
0.013487549,
0.02960714,
0.030622546,
0.018758314,
-0.0030311912,
0.0011715596,
-0.0006634384,
0.011844192,
0.0033201147,
0.036527943,
-0.0013034957,
-0.009913581,
-0.0030228407,
0.0049868524,
0.0133806635,
0.016754221,
0.0051371595,
0.014656602,
0.010140712,
0.033508442,
-0.006142546,
-0.006810577,
-0.0050770366,
0.00048599264,
-0.0062761526,
-0.02014782,
-0.024503382,
-0.0007582153,
0.010260958,
-0.0070143268,
0.027309112,
-0.006810577,
-0.002638723,
0.054671668,
-0.007889448,
-0.0056114616,
0.0073082605,
-0.025037806,
0.0051805815,
0.0017352109,
-0.004803144,
-0.010167434,
0.0068339584,
-0.01438939,
0.036581386,
-0.010708539,
0.012913042,
0.0040248875,
-0.02509125,
-0.0043455423,
0.0013627835,
0.014001932,
-0.014950536,
0.016874466,
0.0031430863,
-0.0049300697,
-0.0176093,
0.009886861,
-0.012712632,
-0.015110864,
-0.029954515,
-0.024449939,
-0.012258371,
0.019840524,
-0.0074351863,
0.019038888,
-0.027790094,
0.013206976,
0.029339926,
0.011216243,
-0.0022145233,
0.016179714,
0.0018187148,
-0.015912501,
0.016567172,
-0.00600894,
0.010127352,
0.002379861,
0.0045025297,
0.039681047,
-0.004048269,
-0.03500483,
-0.0008496521,
0.0042219567,
-0.003971445,
0.03193189,
0.018571265,
0.00816334,
0.016714139,
0.012291772,
0.012064642,
-0.015578486,
0.010815424,
0.022392403,
-0.020962816,
0.01780971,
-0.005942137,
0.012204928,
-0.015845697,
0.000880966,
-0.022886746,
-0.02298027,
-0.03476434,
0.019800443,
0.026427312,
0.012846238,
-0.028190913,
0.009325715,
-0.0038378388,
-0.0054644947,
-0.013988571,
-0.011757348,
-0.0033535163,
0.032947294,
-0.0015414818,
-0.0054143923,
-0.6199329,
0.0041885553,
-0.011476775,
-0.0119978385,
0.023688383,
0.012118084,
-0.001440442,
0.00012880475,
-0.044624478,
0.017448973,
-0.023728466,
0.01524447,
0.006312894,
-0.0037175932,
-0.0056782644,
-0.032813687,
-0.010427966,
-0.012258371,
0.0029293164,
0.005648203,
-0.023701744,
-0.021336913,
0.014883733,
0.025371822,
0.03003468,
-0.00006502865,
0.026253624,
0.010334441,
-0.00013089235,
0.015618567,
-0.005624822,
0.024610266,
-0.0103878835,
0.0011941056,
0.039574165,
-0.012164847,
0.013667917,
0.0062828325,
-0.0028658535,
0.046441525,
-0.020067655,
-0.002424953,
0.020976176,
-0.019559951,
-0.01202456,
0.019653475,
-0.012518903,
-0.013814883,
-0.020521916,
0.016714139,
0.004682898,
0.0060623824,
0.0041317726,
-0.0019072288,
-0.013026607,
0.013420745,
0.01631332,
-0.0068172575,
-0.0056782644,
0.0051004174,
-0.021617487,
-0.017342089,
-0.010588293,
-0.013988571,
-0.012478821,
0.0014897094,
-0.013340581,
0.018972084,
0.00857752,
0.00343368,
0.025612313,
0.014750127,
0.012204928,
-0.0010554892,
0.020388309,
0.015150946,
-0.0010187475,
0.016687417,
-0.0036608106,
0.006593467,
-0.0038478593,
-0.0096530495,
-0.0063663367,
-0.004763062,
0.014309227,
-0.025278298,
-0.027108703,
0.013173574,
0.008764569,
-0.0072614984,
0.0029894393,
0.020962816,
0.00076948834,
0.0012467131,
0.0082702255,
0.018157085,
-0.0013394024,
0.0058853542,
0.0048532463,
-0.051144462,
-0.016700778,
-0.013133491,
-0.0128729595,
0.01652709,
0.004596054,
0.0016358412,
-0.03668827,
-0.0037175932,
0.02811075,
-0.037650235,
-0.022526009,
0.0064732214,
0.013788163,
-0.0012500533,
0.029233042,
-0.03537893,
0.004525911,
0.010862186,
0.0025669097,
0.0054644947,
0.037436463,
-0.012338535,
0.015164306,
0.004252018,
-0.0011456733,
-0.0016066148,
-0.010434646,
-0.0011581989,
-0.00022045027,
-0.0017285305,
0.018290693,
-0.001267589,
0.01436267,
-0.009172067,
0.028377961,
0.014843651,
0.013480868,
-0.011877594,
0.0060690627,
-0.014282505,
-0.025264937,
-0.00600894,
0.012251691,
0.0040015066,
0.015538404,
-0.022659615,
0.013961851,
0.003330135,
-0.0011774049,
-0.020735687,
-0.00072690134,
-0.043502185,
0.0023280885,
0.015378077,
-0.024503382,
-0.008998379,
-0.015324634,
-0.026013132,
-0.01953323,
-0.011697225,
0.022833304,
0.0055814,
-0.007401785,
-0.018771674,
-0.00090017193,
-0.037249416,
-0.0050169136,
-0.00257526,
-0.0024182727,
-0.019867245,
0.018050201,
-0.027763374,
0.001115612,
0.048846435,
-0.011556938,
0.009519444,
0.007254818,
-0.022886746,
-0.0073951045,
-0.0020358248,
0.006456521,
0.0010070569,
-0.03305418,
0.017168399,
0.01094235,
-0.0013636185,
0.020495195,
0.018798396,
-0.0050102333,
0.020455113,
-0.013333901,
0.022526009,
-0.010374524,
0.013213656,
-0.0018170447,
-0.013828244,
0.024022399,
0.014402751,
-0.016126271,
0.03412303,
0.047563817,
0.006115825,
0.01460316,
-0.008677724,
0.0073750634,
-0.0015982644,
0.004398985,
-0.0059588375,
0.022900106,
-0.008236824,
-0.006249431,
0.0060423417,
-0.026373869,
0.0013360622,
-0.007047728,
0.024596905,
0.014509636,
0.007000966,
0.0073550227,
0.009753254,
-0.011576979,
0.00579183,
0.020040933,
-0.0018521163,
-0.024743872,
0.013053328,
0.022405764,
-0.017114958,
0.008784609,
-0.0062794928,
-0.015525043,
0.04700267,
0.0038244782,
0.015618567,
0.008089857,
0.002643733,
0.011890954,
-0.013540991,
0.0038278182,
-0.00343368,
0.009131986,
0.023768548,
0.03842515,
-0.015805617,
-0.0035472452,
-0.017702825,
0.011884274,
0.017168399,
-0.0023965617,
0.015177667,
0.013474188,
0.022178633,
-0.04232645,
0.0060022594,
0.006934163,
-0.01803684,
-0.024543464,
0.0060824235,
0.03217238,
0.034042865,
0.025892885,
-0.011777389,
0.007622235,
0.004375604,
-0.0018921981,
0.020508556,
0.028752059,
0.015324634,
0.0110358745,
-0.031317297,
0.0007001801,
-0.004168514,
-0.0040449286,
-0.0069208024,
0.009940303,
0.013601114,
0.021777814,
0.014082096,
0.022151912,
0.0075019896,
-0.011597021,
-0.029580418,
0.033214506,
0.022726418,
-0.012345215,
-0.009619649,
-0.014656602,
0.0007928694,
-0.0023882112,
0.020428391,
0.010661777,
-0.008858093,
0.023715105,
0.0077959234,
-0.007361703,
-0.029233042,
0.011423333,
-0.024022399,
0.012331855,
-0.00015792673,
0.012552305,
-0.0061091445,
-0.005437773,
-0.001503905,
0.017996758,
-0.0014838642,
-0.009172067,
-0.045426115,
0.0045459517,
-0.0041718544,
0.025585592,
-0.0035472452,
-0.005668244,
0.011216243,
0.009693132,
0.009993746,
-0.016420204,
0.010708539,
-0.0020040933,
0.0053542694,
-0.009111945,
0.0036908719,
-0.0028207614,
-0.011276365,
0.036340892,
0.03193189,
0.012131445,
0.013113451,
0.011309767,
0.02510461,
0.0021911422,
-0.017475694,
0.017742906,
0.013587753,
-0.005234024,
0.0026938354,
-0.014776848,
-0.004372264,
0.0032917233,
0.009813377,
-0.006459861,
-0.027175507,
0.013120132,
-0.0009678101,
-0.00011753172,
0.0140286535,
0.037222695,
0.017542496,
0.007916168,
-0.008651003,
0.020749047,
0.018290693,
0.014656602,
0.012158167,
-0.040669736,
0.009479362,
-0.013707998,
0.031504348,
-0.008443913,
-0.022459207,
0.013881687,
-0.03906646,
0.0050903973,
-0.008377111,
0.011242963,
0.043475464,
0.00056782644,
0.015257831,
0.009619649,
-0.022779861,
0.018638069,
0.0132938195,
-0.019493148,
-0.0074819485,
0.015431519,
0.010454687,
-0.0056782644,
0.017489055,
-0.013333901,
0.007862726,
-0.044971853,
-0.03259992,
-0.0027907,
-0.019266017,
-0.007836005,
-0.03863892,
0.011456734,
-0.013193615,
-0.01267255,
-0.036127124,
-0.025745919,
-0.044116776,
-0.024837397,
-0.0053275484,
-0.01803684,
-0.0145898,
-0.02187134,
0.030996645,
0.0021193288,
0.01870487,
0.002964388,
0.009633008,
0.002725567,
0.030889759,
-0.020949457,
-0.033775654,
-0.006145886,
-0.008437233,
0.010013786,
-0.0041551534,
-0.008610921,
0.00429544,
-0.015765535,
-0.00046219403,
0.020495195,
-0.020214621,
-0.0054411134,
-0.019199215,
-0.00019633851,
0.0073082605,
0.0018137045,
0.017261924,
-0.004419026,
-0.019199215,
0.0067471145,
-0.03604696,
-0.008470635,
-0.028511569,
-0.0071546133,
0.026747966,
0.0003358944,
0.018117003,
-0.018932002,
-0.0046194354,
0.019880606,
-0.010347802,
-0.00922551,
-0.00087512075,
-0.003944724,
0.033935983,
-0.020348229,
0.023033714,
0.0321991,
-0.02920632,
-0.015431519,
0.0026554237,
0.032813687,
-0.017315367,
-0.024490021,
0.009278952,
0.012204928,
-0.013801523,
-0.025932968,
0.0054010316,
-0.0035305445,
0.034256637,
-0.0055479985,
-0.011423333,
-0.033508442,
-0.026013132,
-0.04852578,
0.015952583,
-0.0089182155,
-0.0078092837,
-0.023247482,
0.0039547444,
-0.026039854,
-0.02535846,
0.012478821,
-0.021363635,
0.023888793,
0.0167275,
-0.037623513,
-0.0012124765,
0.015177667,
0.0014137209,
-0.047163,
-0.027148785,
-0.0046494966,
-0.043689236,
-0.01718176,
-0.028645175,
0.011710585,
0.014148899,
0.03238615,
-0.017034793,
-0.0075888336,
0.00002031493,
0.007882767,
0.02705526,
-0.005280786,
0.003694212,
-0.023781909,
0.01953323,
-0.0017151699,
-0.025639035,
0.03495139,
-0.0136077935,
0.016446926,
0.031477626,
-0.023528056,
-0.027977142,
-0.0150307,
-0.02877878,
-0.026721245,
0.003754335,
0.024984363,
-0.00003358422,
-0.023942236,
-0.015204389,
0.010013786,
0.022699697,
0.013554351,
-0.0054845354,
0.013654556,
-0.018825117,
0.005020254,
-0.012391977,
-0.0070076464,
-0.008731167,
0.004118412,
-0.0052039623,
0.01223165,
-0.001823725,
-0.009065182,
0.031477626,
0.0021360295,
-0.026774688,
-0.018624708,
0.024022399,
-0.014897094,
0.011283046,
0.006072403,
-0.01611291,
-0.014108817,
0.01007391,
0.004806484,
-0.011536897,
-0.011857552,
0.008964977,
-0.0049133687,
0.027816815,
-0.004372264,
-0.009319034,
0.0038879411,
-0.039360393,
0.031851724,
0.002383201,
0.015725452,
0.006723733,
0.01588578,
0.0022913467,
-0.0155517645,
-0.00493675,
0.014188981,
0.03839843,
0.03644778,
0.008751208,
-0.020642161,
0.023247482,
-0.000526492,
-0.041979074,
-0.022245437,
0.0008951617,
0.029660583,
-0.011015833,
-0.006075743,
-0.015444879,
-0.028832223,
0.01567201,
-0.0052540647,
-0.017582579,
0.00429878,
-0.0033885879,
0.0012149815,
0.040001705,
-0.029099436,
0.009359116,
-0.032760248,
0.027242308,
0.01825061,
-0.022632895,
-0.010815424,
0.009332395,
-0.019853884,
0.026894933,
-0.0011982808,
-0.011924355,
0.0077959234,
-0.003694212,
-0.0112630045,
-0.022191994,
-0.009486042,
0.043475464,
0.009853459,
-0.00017285305,
0.033134345,
0.005471175,
0.0052073025,
-0.0014646582,
-0.011516857,
-0.006503283,
-0.005761768,
-0.00022608678,
0.025011085,
0.009566206,
-0.046548408,
-0.011423333,
-0.015525043,
0.010548212,
0.00054277526,
-0.02877878,
0.026935015,
-0.030889759,
0.027001819,
-0.0016592223,
0.006115825,
0.0072214166,
0.01181747,
-0.0038177979,
0.012458781,
0.019920688,
-0.022686336,
0.013854966,
0.008490675,
-0.011182841,
-0.02832452,
0.023300925,
-0.033989422,
-0.019760361,
-0.008069816,
-0.023781909,
-0.035138436,
-0.012619108,
0.0055446583,
-0.0037877364,
0.013935129,
-0.017074876,
0.034844503,
0.01287964,
0.0052640853,
-0.01460316,
-0.007989652,
0.0062561114,
-0.011543578,
0.016460286,
0.03302746,
-0.002231224,
0.021604126,
-0.026948376,
0.021697652,
0.021577405,
-0.037489906,
0.0048265248,
0.020040933,
0.008524077,
-0.0121381255,
-0.004372264,
-0.01694127,
-0.03048894,
-0.014897094,
-0.0074151456,
-0.003066263,
-0.018771674,
-0.015565125,
0.008657684,
0.0061525665,
0.011209562,
-0.015752174,
-0.016994711,
-0.016433565,
0.0057417275,
-0.043448742,
-0.010541531,
-0.014710045,
0.02939337,
0.010040508,
-0.034203194,
-0.019439705,
-0.007836005,
-0.016660696,
-0.00040770773,
-0.003670831,
0.024971003,
-0.015484962,
0.016607253,
0.0244633,
0.0012567336,
0.023100516,
0.004358903,
-0.034096308,
-0.012599067,
0.032947294,
-0.0069074417,
0.044303823,
-0.0008241834,
-0.030221729,
-0.016340042,
0.017128319,
0.0033551862,
0.011730626,
0.024196086,
0.003884601,
0.03476434,
-0.012011199,
-0.017462334,
-0.020775767,
-0.00091603765,
0.025465347,
-0.025786001,
0.010862186,
0.00091937784,
0.012746034,
-0.013333901,
-0.022379043,
-0.0056548836,
-0.009065182,
-0.005604781,
-0.03027517,
0.006823938,
0.0075687924,
-0.0035105036,
-0.010855505,
0.031878445,
0.0063629965,
-0.00015260336,
0.012171527,
-0.011336488,
-0.02684149,
-0.0012575686,
0.0058586327,
0.01823725,
0.003331805,
-0.0010437986,
-0.01870487,
-0.014135539,
0.028271077,
-0.012131445,
-0.0054010316,
0.008410512,
0.0000053135873,
-0.023407811,
0.039627608,
0.002167761,
0.0070944903,
0.00032169872,
0.014937175,
-0.016273238,
-0.0016967991,
-0.0128729595,
0.012599067,
-0.046388082,
-0.00020239255,
-0.0101073105,
-0.030328613,
0.025505427,
-0.014082096,
-0.0015189358,
0.0052206633,
0.0030579125,
0.19720279,
0.00079537457,
0.008871453,
0.023741826,
0.01631332,
0.0012759394,
0.038719084,
0.011804109,
-0.014990618,
0.016500369,
0.036180567,
-0.01803684,
-0.014001932,
-0.0050336146,
0.016593892,
-0.036153845,
-0.0244633,
-0.023247482,
0.0008112403,
0.000439648,
0.003111355,
0.011116038,
0.037195973,
-0.023434531,
0.0006008105,
0.0051839217,
-0.00039017192,
-0.0064665414,
0.030195007,
0.010855505,
-0.020227982,
0.004565993,
0.003370217,
-0.0065533854,
0.019653475,
0.0050135734,
-0.0074819485,
-0.0016876137,
-0.015618567,
-0.0073683835,
-0.014055375,
0.021403717,
-0.009920262,
-0.005197282,
0.0058719935,
0.030408777,
0.012966484,
-0.013166893,
0.007836005,
-0.014522997,
-0.037008923,
0.0014329267,
0.005097077,
0.02061544,
-0.021537323,
0.0065533854,
0.05210643,
-0.0052240035,
-0.022352321,
0.02811075,
-0.00965973,
0.003931363,
0.012118084,
0.007535391,
0.0028107408,
0.008123258,
0.0047196397,
0.011931036,
-0.014616521,
0.023568138,
0.012118084,
0.0058452724,
0.00050812116,
-0.0024366435,
-0.00515052,
-0.017021433,
0.012004519,
0.023434531,
0.024743872,
0.023741826,
0.014255784,
-0.022819944,
-0.0027222268,
-0.0061124847,
-0.029500253,
-0.0073082605,
0.028217634,
0.016166354,
-0.017796349,
0.0062594516,
-0.0006016455,
-0.011343168,
-0.03497811,
-0.018972084,
0.006369677,
-0.014416112,
0.00579183,
-0.0060022594,
-0.004859926,
-0.0050536552,
-0.01678094,
0.065841146,
0.02040167,
0.013454147,
-0.0090050595,
-0.015591847,
0.0044390666,
0.016647335,
0.011977798,
0.0022429144,
0.020268064,
-0.0072013754,
0.0067337537,
-0.0137480805,
0.0034052886,
0.011336488,
0.016046107,
-0.015792256,
0.033080902,
-0.009405878,
-0.005234024,
-0.013253737,
-0.01738217,
0.016674057,
-0.024610266,
-0.017876513,
0.0041918955,
-0.00879797,
-0.0002275481,
-0.002386541,
0.0010872206,
-0.007916168,
-0.00010192693,
0.001222497,
0.015311273,
-0.014122178,
-0.001244208,
0.0032366107,
-0.03193189,
0.0036975523,
0.018838478,
0.0076289154,
-0.01652709,
0.007061089,
0.009085223,
0.0022045027,
-0.012826198,
-0.008296946,
-0.03436352,
0.0011465084,
0.00472966,
-0.018063562,
0.0066869915,
-0.019747,
0.017956676,
-0.02832452,
-0.035111714,
-0.032118935,
0.0244633,
0.0073683835,
-0.03778384,
0.005260745,
0.014108817,
0.003303414,
-0.0015423169,
-0.01890528,
-0.167275,
0.0067938766,
0.013841605,
-0.019720279,
0.029339926,
0.01460316,
0.015912501,
0.0006488252,
-0.002062546,
-0.017729545,
0.001052984,
0.02295355,
-0.019693557,
-0.017515777,
-0.018290693,
0.027295751,
-0.019453065,
0.01866479,
0.02872534,
0.004592714,
0.036180567,
-0.029687302,
0.0012625788,
-0.003563946,
-0.001802014,
0.01436267,
-0.02510461,
-0.0004805649,
0.03265336,
-0.01094235,
-0.024864119,
0.011296406,
0.03561942,
0.006072403,
-0.019640114,
0.00090518215,
0.007668997,
0.006369677,
-0.0040415884,
0.0150307,
0.0057016457,
0.008858093,
0.010187475,
-0.004783103,
-0.015110864,
0.021777814,
-0.0066836514,
-0.00003778551,
0.019934049,
0.012378616,
0.01501734,
-0.015097504,
0.016206436,
-0.001780303,
0.008397151,
0.014282505,
0.008711126,
0.023808628,
0.004746361,
0.005684945,
-0.0020341547,
-0.025037806,
0.007862726,
-0.0032299305,
0.006115825,
-0.022165272,
0.006185968,
-0.023354368,
-0.02832452,
0.019880606,
-0.009085223,
-0.0055346377,
0.010621695,
-0.012251691,
0.05691625,
0.024343055,
-0.009639689,
0.0102475975,
0.032813687,
0.010995792,
-0.020081015,
-0.0043956446,
-0.02082921,
0.004833205,
0.007061089,
-0.009953664,
0.016353402,
0.028858945,
-0.0012867949,
0.009960344,
0.006887401,
-0.016593892,
0.0029343267,
-0.023915514,
-0.008744528,
0.0023598198,
-0.025799362,
0.0011506836,
0.03243959,
-0.042112682,
0.02424953,
-0.02171101,
-0.020134458,
-0.00493675,
0.038772527,
-0.00708113,
-0.03671499,
0.011864233,
0.015070782,
-0.025532149,
-0.011490135,
-0.0023280885,
-0.006914122,
0.037489906,
-0.020855932,
0.02036159,
-0.00020698526,
0.01223833,
0.026373869,
-0.028084029,
0.07107851,
0.0012550635,
-0.020575358,
-0.030515661,
-0.021363635,
-0.0030746132,
-0.11222923,
-0.026480753,
0.030515661,
0.031744838,
-0.025264937,
0.026694523,
-0.008784609,
0.019920688,
-0.01096239,
0.045025297,
-0.00857752,
-0.023100516,
-0.022940189,
-0.008196742,
0.024850758,
-0.008651003,
-0.0015690381,
-0.020334868,
-0.0032382808,
0.035111714,
0.029794188,
-0.012298453,
0.015845697,
-0.012071323,
-0.010361163,
-0.0065333443,
-0.0005060336,
0.028511569,
-0.006052362,
0.0005001883,
0.0064064185,
0.0133806635,
0.014883733,
-0.0037342939,
-0.035138436,
-0.029580418,
-0.039440557,
-0.010427966,
0.007869407,
-0.018170446,
0.011049234,
-0.01137657,
0.001994073,
-0.014442833,
0.02016118,
-0.00028683586,
-0.021697652,
-0.015738813,
0.0014763487,
-0.028217634,
-0.04633464,
-0.019987492,
0.00536095,
0.0015498322,
0.013881687,
-0.032092214,
-0.0063596563,
0.0030863038,
-0.021817897,
-0.000633377,
-0.011784069,
0.022272158,
-0.028591732,
0.026761327,
0.022592813,
0.004338862,
-0.016246516,
-0.02014782,
-0.008704445,
0.0015899141,
-0.022619534,
0.008844732,
-0.013975211,
0.006292853,
-0.0056348424,
-0.0049434304,
-0.008878133,
-0.010501449,
0.028137472,
-0.037623513,
0.0009678101,
-0.025037806,
0.044597756,
-0.0012809497,
-0.026747966,
0.016847745,
0.022873385,
-0.027309112,
-0.006974245,
-0.022926828,
-0.0076556364,
0.012979845,
-0.0155517645,
-0.05368298,
-0.020775767,
0.004225297,
-0.04657513,
-0.019666836,
0.028190913,
0.022833304,
-0.020708965,
-0.025224855,
-0.06872704,
0.028885666,
0.010120671,
-0.023487974,
0.016847745,
-0.0067938766,
0.0067137126,
0.02533174,
0.01694127,
0.0055880803,
-0.024783954,
-0.0036875317,
-0.02082921,
-0.02020126,
-0.0060256408,
-0.013180254,
0.01740889,
0.01030104,
0.011276365,
0.013895047,
-0.000037107042,
-0.0004223209,
0.010541531,
0.022632895,
-0.006807237,
-0.006349636,
0.018277332,
0.0352186,
-0.0019823823,
-0.014910455,
-0.0048265248,
-0.019987492,
-0.018638069,
-0.013841605,
0.0032733525,
0.000214605,
0.007582153,
0.024850758,
0.029152878,
0.014416112,
-0.036367614,
-0.010113991,
0.017996758,
-0.0070744497,
-0.01931946,
-0.001651707,
-0.009118625,
0.0152711915,
0.000493508,
0.0045426115,
-0.010661777,
0.0049000084,
0.030355334,
-0.022071749,
-0.033000737,
-0.0053342283,
0.0056515434,
-0.003477102,
-0.026480753,
-0.004362243,
0.031237135,
-0.0015757184,
-0.0015314614,
0.0044691283,
0.025732558,
-0.026908293,
-0.022445846,
-0.00901174,
-0.00053317234,
-0.0049300697,
-0.026494114,
-0.004161834,
-0.024971003,
0.039173346,
-0.00031167828,
0.019185854,
-0.015097504,
0.02577264,
0.017422251,
0.010200835,
-0.035325486,
-0.0029810888,
-0.006853999,
0.0039079823,
-0.004125092,
0.009773295,
0.011877594,
0.01631332,
0.0010655096,
0.015484962,
-0.0131535325,
0.012532264,
-0.009946983,
-0.007214736,
-0.0071412525,
0.015578486,
0.0038612199,
-0.003911322,
0.001758592,
0.014549718,
0.01994741,
0.001997413,
0.0034837823,
-0.026788048,
-0.010755301,
0.0073951045,
-0.038478594,
-0.04232645,
0.0017134998,
0.026373869,
-0.005050315,
0.0098735,
0.00038390912,
-0.0060356613,
0.008190062,
-0.014068736,
0.00857084,
-0.016567172,
-0.011396611,
0.019078968,
-0.0032917233,
0.03385582,
0.014937175,
0.0011657143,
0.028538289,
0.012779435,
0.018838478,
-0.014335948,
0.02960714,
-0.013561032,
0.033455,
0.0068940814,
-0.035352208,
-0.018076923,
0.024396496,
-0.038157936,
-0.006847319,
-0.0076756775,
-0.010294359,
0.09005059,
0.008564159,
-0.032519754,
0.008437233,
0.0032132296,
0.0416317,
-0.0056548836,
0.009786656,
-0.032118935,
-0.019252656,
0.028671896,
-0.005938797,
0.017168399,
-0.024222808,
-0.021644209,
-0.0028691937,
0.011396611,
-0.011389931,
-0.0058686533,
-0.040936947,
0.023407811,
-0.02789698,
0.007548752,
0.0034269996,
-0.013814883,
0.0019306099,
0.01780971,
0.007682358,
0.0054644947,
-0.017836431,
0.012966484,
0.009492722,
-0.016540451,
-0.00857752,
0.00622605,
-0.017208481,
-0.0009778305,
0.0004763897,
0.009405878,
-0.009499403,
-0.013761441,
0.016072828,
-0.027549604,
-0.040643014,
-0.00493341,
-0.019680196,
0.0021978223,
0.010768661,
-0.021363635
] |
The exploration of brain epigenomes, which consist of various types of DNA methylation and covalent histone modifications, is providing new and unprecedented insights into the mechanisms of neural development, neurological disease and aging. Traditionally, chromatin defects in the brain were considered static lesions of early development that occurred in the context of rare genetic syndromes, but it is now clear that mutations and maladaptations of the epigenetic machinery cover a much wider continuum that includes adult-onset neurodegenerative disease. Here, we describe how recent advances in neuroepigenetics have contributed to an improved mechanistic understanding of developmental and deg | [
-0.015981922,
0.0137488665,
0.013262008,
-0.040740266,
-0.036949266,
0.015904024,
-0.0046089212,
0.0009664129,
-0.021941062,
-0.003294405,
-0.014164318,
0.01709845,
0.007906572,
0.004888053,
0.0034501995,
-0.006971805,
0.04512848,
-0.011593709,
-0.024394825,
0.0023661293,
-0.042661734,
0.009367146,
0.029055677,
-0.020655757,
-0.00988646,
0.028536363,
-0.005154202,
-0.049386863,
-0.014423976,
-0.010548587,
0.019071845,
0.023187418,
-0.0017705398,
-0.02003258,
-0.0002736547,
-0.005410614,
0.0003509434,
-0.0140215065,
-0.009003625,
-0.012087058,
0.0010921846,
0.0007104068,
-0.014320113,
-0.010568062,
-0.011334051,
-0.008075349,
-0.00001295118,
-0.018253924,
-0.010009798,
0.023888493,
0.008750459,
0.02626436,
0.0041804863,
0.008055875,
-0.0114833545,
-0.02495309,
0.0025835924,
0.012444087,
0.017487936,
-0.005608603,
-0.0018354543,
-0.006462227,
-0.020422066,
0.00007820155,
-0.014242216,
0.024628518,
0.006335644,
0.0032035247,
-0.0030883017,
0.008425887,
0.03466428,
0.005884489,
-0.024407808,
-0.019175708,
0.015138035,
-0.0009866987,
-0.019058863,
-0.022577222,
0.004927002,
0.015592435,
0.013294466,
-0.018331822,
-0.022758983,
0.02960096,
-0.001161156,
-0.0055728997,
-0.014449942,
0.0035443255,
0.022252651,
-0.004949722,
-0.007867623,
-0.0042356635,
0.024589568,
-0.002312575,
-0.009315214,
0.012307767,
0.0015709281,
0.022460377,
-0.00457971,
-0.0033950224,
-0.019669058,
0.026978418,
0.0046381326,
-0.014865394,
-0.0407922,
0.0063194153,
0.043181047,
-0.0053262254,
0.009276265,
0.00042721778,
-0.010808245,
-0.00027345185,
-0.0074521713,
-0.030302035,
0.041778896,
0.006205815,
0.013891678,
0.001497088,
0.01254795,
-0.013197094,
0.0063194153,
0.022733018,
0.014878376,
-0.02323935,
-0.0056767627,
0.010827719,
-0.03443059,
-0.00862063,
0.0062382724,
-0.010879651,
-0.00370012,
-0.011678098,
0.0052548195,
0.0048750704,
-0.04390809,
0.02788722,
0.016760893,
-0.0019685286,
-0.02721211,
-0.0360145,
0.014852411,
0.027341938,
-0.026952453,
-0.0033658107,
0.011768978,
0.03235333,
-0.0054235966,
0.02179825,
0.023499006,
-0.005348945,
0.010360336,
-0.007049702,
0.033885308,
0.0008049384,
-0.0055988654,
0.026978418,
0.006958822,
0.02631629,
-0.020928398,
-0.0065790727,
0.0048977905,
-0.018695343,
-0.0170595,
0.008010435,
0.0073807654,
0.022733018,
-0.007328834,
-0.021265952,
0.02192808,
-0.02622541,
-0.021785267,
0.009704701,
-0.03832545,
-0.008166229,
-0.01439801,
0.01430713,
0.025628198,
0.030172206,
-0.03344389,
-0.02075962,
0.005559917,
0.01480048,
0.0027150442,
0.0024407809,
0.0030477303,
-0.0019393172,
0.020409083,
-0.00047752642,
0.0047484874,
-0.020499963,
0.0035702912,
0.006764079,
-0.020461014,
-0.013437278,
-0.6385498,
-0.026394188,
-0.0077962177,
-0.029756753,
0.011145799,
0.018539548,
0.006598547,
0.005400877,
-0.012801116,
0.025745045,
-0.01963011,
0.016280528,
0.014268181,
0.0010021158,
-0.024940107,
-0.04377826,
-0.00404092,
-0.0260826,
0.030743452,
0.010535604,
-0.02996448,
-0.0047679613,
-0.0057643973,
-0.0079390295,
-0.01665703,
0.025303626,
0.017448986,
0.006718639,
-0.0050341105,
0.027238075,
-0.0379879,
0.01990275,
-0.03297651,
-0.0018046199,
0.051516056,
0.0071275993,
0.0056929914,
0.05385297,
0.002903296,
0.019746955,
-0.0012633962,
-0.016059818,
-0.0008069669,
0.008958185,
-0.02094138,
0.014865394,
0.0012147104,
0.0041480293,
0.007523577,
0.00015934453,
0.009905935,
-0.0033593194,
-0.009230825,
0.011684589,
0.008510276,
0.013645004,
0.01394361,
-0.020603826,
0.027186144,
-0.0017640484,
-0.008581681,
0.022603188,
-0.02983465,
-0.01868236,
-0.013787815,
0.020551894,
-0.020318203,
0.00041261205,
-0.014449942,
-0.023395143,
0.0054365797,
0.028847951,
-0.0019149743,
-0.012223379,
0.012573916,
0.026640864,
0.02721211,
0.015125051,
-0.030068344,
0.02928937,
-0.017163362,
0.000375692,
-0.019162726,
-0.000687281,
0.035053767,
-0.02788722,
-0.009789089,
0.013606055,
-0.009107488,
0.0032749306,
-0.00076152687,
0.00020011887,
0.010645959,
-0.03780614,
-0.012924454,
0.011457389,
0.021421747,
0.019565195,
0.008776424,
0.0042129434,
-0.026952453,
-0.0072054965,
0.012814099,
0.012087058,
0.0147355655,
0.007822183,
-0.010931582,
0.006147392,
0.067407094,
0.0106654335,
-0.007166548,
0.01074333,
-0.03471621,
0.018279891,
-0.023018641,
-0.02513485,
-0.0011019217,
-0.006796536,
-0.0019669058,
-0.027705459,
0.02965289,
0.0044239154,
-0.012528476,
-0.019967664,
0.02825074,
-0.002554381,
-0.01078877,
-0.00089662994,
-0.022122823,
-0.024654483,
0.0014183793,
-0.0088413395,
0.009951375,
-0.021162089,
0.0028464957,
0.009075031,
0.009100997,
-0.02451167,
-0.020409083,
-0.01596894,
-0.0062707295,
-0.010671925,
0.013580089,
0.04024692,
-0.01611175,
-0.025965754,
-0.007841658,
-0.007828674,
0.00061141234,
0.0011749504,
0.009373637,
0.030120274,
-0.02387551,
0.021564558,
0.017877422,
-0.0009656015,
0.0030152733,
-0.023537956,
0.0038591602,
-0.027341938,
-0.0011376246,
0.023563921,
-0.0016196138,
0.000062784384,
-0.018085148,
-0.015670333,
-0.017202312,
0.010133135,
-0.0030022901,
-0.03723489,
-0.00753656,
0.009672243,
-0.028458467,
-0.0070302277,
0.0018208484,
0.017487936,
0.0072833938,
-0.0086725615,
-0.009094506,
-0.0049302476,
-0.011723538,
-0.0029260158,
-0.0022914778,
0.0029568502,
0.032742817,
0.008497293,
0.034093034,
0.005352191,
0.015683316,
0.025433457,
0.009776106,
0.041311514,
-0.019759938,
0.005916946,
0.008802391,
-0.032379296,
0.00570922,
-0.000011455107,
-0.0072639193,
0.031496458,
0.015540504,
-0.021019278,
0.0030785648,
-0.005225608,
0.02721211,
-0.04201259,
-0.0010077958,
-0.012333733,
-0.023550939,
-0.0042129434,
-0.01724126,
-0.0020902432,
-0.010412267,
-0.0010621616,
0.00039131203,
0.011132817,
-0.025056953,
-0.001144116,
-0.019513264,
-0.023031624,
0.006355118,
-0.010399285,
0.012483036,
0.0043362807,
0.0068095187,
0.020733654,
0.0072833938,
0.010899125,
-0.007614457,
-0.02003258,
0.000384212,
0.028017048,
0.00043452065,
-0.0059007173,
0.00030448902,
0.02965289,
0.009003625,
-0.016773878,
0.013917644,
0.008432378,
0.01602087,
0.011496337,
-0.0052905222,
-0.0039273202,
0.014320113,
0.007166548,
0.03827352,
-0.0026030669,
-0.007724812,
0.0034274794,
-0.025783993,
-0.0021924833,
-0.0065466156,
0.0034404623,
-0.0027458784,
-0.020435048,
-0.0039273202,
0.014657668,
0.04427161,
0.019759938,
0.008925728,
-0.021629473,
-0.023044607,
-0.013761849,
0.0047257673,
0.0044239154,
0.021564558,
0.009237316,
-0.00672513,
-0.0025170553,
-0.030328,
-0.007770252,
-0.007108125,
-0.03136663,
0.016397374,
0.00033349765,
0.0028984272,
0.015735246,
0.025160816,
0.01186635,
-0.0017299684,
-0.017526884,
0.036533814,
0.03858511,
-0.01286603,
-0.0034923938,
-0.0020853747,
-0.009957867,
-0.019097812,
-0.0027101755,
0.0060175634,
0.0061668665,
-0.015319794,
-0.025082918,
-0.030951178,
-0.007919555,
0.012418122,
-0.0027101755,
0.009496975,
-0.01864341,
-0.0030542219,
0.0041902233,
-0.017929353,
0.022083873,
0.025615215,
0.026588932,
-0.008153247,
0.00021320318,
-0.012418122,
-0.025381524,
-0.00032254335,
-0.01272322,
-0.0008300927,
-0.014501873,
-0.005673517,
0.0022557748,
-0.00376828,
0.00048685787,
0.011509321,
0.025303626,
-0.019214658,
-0.035079733,
-0.0123856645,
0.009672243,
0.043518603,
0.025628198,
-0.027290007,
0.016397374,
0.009737157,
-0.008503784,
-0.009464517,
-0.0039467947,
0.028951814,
-0.016981604,
0.0091334535,
0.026978418,
0.0015238652,
0.010373319,
0.0073872567,
0.01665703,
0.016150698,
-0.0075884913,
-0.027030349,
-0.007361291,
-0.0061895866,
-0.0031743133,
0.019409401,
0.035209563,
0.026640864,
-0.004096098,
0.015267863,
0.019344486,
-0.00047022357,
-0.018435685,
-0.0041545206,
0.008179212,
0.014047473,
0.03227543,
0.00057570945,
-0.0076014744,
-0.0034599367,
0.01218443,
0.028146876,
-0.010899125,
0.011619675,
0.002358015,
0.018266907,
0.0012358075,
0.017838473,
-0.0019393172,
0.019201675,
-0.009587854,
-0.027705459,
-0.017007569,
0.008140264,
-0.018669376,
-0.009938392,
-0.024200082,
0.030977145,
0.003039616,
0.022226686,
-0.011028954,
0.0062545007,
-0.0015847224,
0.0065953014,
-0.013255517,
-0.0017851456,
-0.0068939077,
-0.005144465,
-0.02806898,
-0.0166051,
0.0056832545,
-0.017384073,
-0.0106654335,
0.0010142872,
-0.027367905,
-0.038740903,
0.0050016535,
0.042220317,
0.021590523,
0.00462515,
-0.029263405,
-0.00871151,
0.021992993,
-0.004946476,
-0.004264875,
0.014177302,
-0.015345761,
0.022758983,
-0.01592999,
-0.00749112,
-0.014644685,
-0.01809813,
0.011048428,
0.02455062,
-0.013904661,
0.022642137,
0.025861891,
-0.012288293,
0.025654165,
0.023499006,
0.028146876,
0.0035508168,
-0.007945521,
-0.011872841,
-0.013917644,
-0.018279891,
-0.024654483,
-0.008179212,
-0.013333415,
-0.019409401,
0.0008049384,
-0.0024326665,
-0.0073937485,
0.01227531,
-0.023135487,
0.0038429315,
0.014060455,
0.022408444,
0.026926486,
0.014372044,
0.00961382,
0.014086422,
0.0024067007,
0.0048491047,
-0.02079857,
0.022603188,
0.005680009,
-0.006614776,
0.0054722824,
0.0060045803,
0.0020301973,
-0.013047791,
0.0073547997,
-0.0028140387,
0.034508485,
-0.011775469,
-0.02892585,
-0.020772602,
-0.0096787345,
-0.006637496,
0.016267546,
0.01250251,
-0.008659579,
0.004070132,
-0.004914019,
-0.014073438,
-0.004901036,
0.0145667875,
-0.0407922,
0.002807547,
0.010873159,
-0.01299586,
0.007478137,
-0.0076923547,
0.009561889,
-0.011879332,
-0.015618401,
-0.025615215,
-0.012755676,
0.0121130245,
0.0041480293,
0.045907453,
0.014138353,
0.046946082,
0.0015238652,
0.012729711,
0.02021434,
0.017410038,
-0.011002989,
-0.007594983,
0.015865076,
-0.01791637,
0.016592117,
-0.0011717046,
-0.0020853747,
0.015631383,
-0.03718296,
0.010607011,
0.025822941,
0.0038429315,
-0.048763685,
-0.0025040724,
-0.04902334,
-0.021746319,
0.022213703,
-0.004888053,
0.030302035,
-0.04286946,
0.01616368,
0.018305857,
0.008445362,
0.006757587,
-0.016046835,
0.016592117,
-0.01809813,
0.016994586,
-0.0025981981,
0.0037650343,
0.0036481884,
-0.025745045,
-0.005585883,
-0.015761212,
0.02139578,
0.0016269167,
0.03931215,
-0.0036806455,
-0.0075625256,
0.0014370421,
0.028977782,
-0.015891042,
-0.0102045415,
-0.016345441,
-0.020110477,
-0.0004576464,
-0.00494323,
0.0068874164,
-0.033521786,
0.021863164,
0.0023158207,
-0.012625848,
0.03484604,
-0.011626166,
0.003583274,
0.004888053,
-0.0117559945,
0.0040766234,
-0.03796193,
0.024083236,
0.008581681,
-0.0007704526,
-0.035910636,
0.0010564816,
-0.005124991,
0.007062685,
0.06029248,
0.0022963462,
-0.010178575,
-0.004508304,
-0.0068939077,
0.0031369876,
-0.021006295,
-0.019474315,
0.004969196,
-0.00094207,
-0.0030201417,
0.0031645761,
-0.0035735369,
-0.02157754,
0.0105810445,
-0.011684589,
0.03185998,
-0.0028821987,
-0.035053767,
-0.013774833,
0.021214021,
-0.011898806,
0.024602551,
0.013236043,
0.008107807,
-0.000572058,
-0.00744568,
-0.0078546405,
0.014190285,
0.014385028,
0.029626925,
-0.019331504,
-0.0012650191,
0.01308674,
0.009289248,
-0.0050827963,
-0.007199005,
-0.011067903,
0.0426877,
-0.022694068,
-0.0009055557,
0.01656615,
0.0011222074,
0.023226367,
0.008692036,
0.0075430516,
-0.03967567,
-0.017202312,
-0.01899395,
0.016280528,
0.020655757,
-0.010645959,
-0.011794943,
-0.022317566,
0.017461969,
-0.033236165,
-0.017682679,
0.03204174,
-0.029445164,
0.0031645761,
0.011794943,
0.02613453,
0.031470492,
0.019733973,
0.0026744725,
-0.024628518,
0.026277343,
0.010529113,
0.016189648,
0.011373,
0.0029341301,
-0.018565513,
0.01119124,
-0.02540749,
-0.022408444,
-0.012281802,
-0.036845405,
-0.03803983,
0.005456054,
0.0047257673,
0.023135487,
0.015605418,
-0.023174435,
-0.0052807853,
-0.008341499,
0.009899444,
-0.006692673,
-0.028406534,
0.019032897,
-0.039753567,
0.00023369178,
0.008133773,
-0.0073547997,
-0.030224137,
-0.0032700622,
-0.017124414,
0.005949403,
-0.018111113,
-0.007789726,
-0.002345032,
0.018240942,
0.0022168262,
0.021278935,
-0.0052191163,
-0.018721309,
-0.021408765,
0.003420988,
-0.013917644,
0.011152291,
-0.016072802,
0.023434093,
0.019409401,
0.018137079,
-0.010003307,
0.012268819,
-0.006484947,
-0.043336842,
-0.04666046,
0.0027150442,
-0.0203961,
0.015865076,
0.038663007,
-0.02148666,
-0.016124733,
-0.015306812,
-0.03926022,
-0.008010435,
0.0134762265,
0.007744286,
0.03552115,
0.026043652,
0.0007022925,
-0.0026663584,
-0.0014329851,
0.014423976,
0.017786542,
0.008464836,
0.007192514,
-0.013262008,
0.016007887,
-0.000286029,
-0.003914337,
-0.006783553,
0.02793915,
0.0003675777,
-0.036326088,
0.0000660301,
0.0014824823,
0.027835287,
-0.008088333,
0.02329128,
0.017526884,
0.0009980587,
0.03718296,
-0.008653088,
0.01164564,
-0.014112387,
-0.0016277282,
-0.027315972,
0.0023645065,
-0.008386939,
-0.007744286,
-0.00067957246,
-0.023096537,
-0.027523698,
0.017955318,
-0.016903706,
0.016890723,
0.022096856,
0.019461332,
0.00857519,
0.008886779,
-0.0039727604,
-0.022642137,
-0.017890405,
-0.020915415,
-0.0054722824,
-0.012911471,
-0.022330549,
-0.005813083,
0.011223697,
-0.0013875449,
-0.019552212,
-0.007893589,
-0.013554123,
-0.017812507,
-0.01831884,
0.006043529,
0.007036719,
-0.0105615705,
-0.0072833938,
-0.0063161696,
-0.023278298,
-0.0042583835,
0.0003004319,
-0.0050600762,
-0.022590205,
0.009393112,
-0.014774513,
-0.0117559945,
-0.008380447,
0.0033885308,
-0.014631703,
-0.02192808,
0.0057027284,
0.16368811,
-0.010892633,
-0.020876465,
0.0049854247,
0.0003566234,
-0.012067584,
0.018176027,
0.0109380735,
0.0013899793,
-0.004936739,
0.02338216,
0.006416787,
-0.02856233,
0.004112326,
0.03710506,
-0.017565832,
-0.028666193,
-0.0074197142,
-0.010048747,
-0.007887098,
0.024057271,
-0.0039013545,
-0.00672513,
-0.002116209,
0.012807608,
-0.011593709,
-0.012664797,
0.01602087,
0.01250251,
0.011476863,
-0.031548392,
0.017020551,
0.005189905,
0.004342772,
-0.020538911,
-0.004229172,
0.011996178,
-0.0045959386,
-0.02017539,
0.0032781763,
0.018980965,
0.010347352,
-0.00478419,
-0.00023004034,
-0.0056280773,
0.03050976,
0.012483036,
-0.013956592,
-0.007224971,
-0.030743452,
-0.039831467,
-0.0055631627,
0.0044304067,
0.030353965,
-0.0024927123,
-0.011145799,
0.008386939,
0.018435685,
-0.008581681,
0.019889766,
-0.025848908,
0.007731303,
-0.031418562,
0.029626925,
-0.00046738356,
0.035235528,
-0.0023434092,
-0.030665554,
0.027004384,
-0.01403449,
0.008088333,
-0.0078546405,
-0.023680767,
-0.006757587,
0.006978296,
-0.019785903,
0.06382382,
0.004518041,
0.025212746,
0.012742694,
0.018539548,
-0.0021178317,
-0.025485387,
0.021369815,
-0.007192514,
-0.07374274,
0.0558783,
0.008036401,
-0.03082135,
-0.027705459,
0.0046868185,
-0.004797173,
-0.004031183,
0.010795262,
0.016397374,
-0.0047549787,
0.004255138,
0.01209355,
-0.02161649,
0.005848786,
-0.03822159,
0.06943242,
0.0013558991,
0.018916052,
-0.004342772,
0.014852411,
-0.00065969245,
0.023356196,
-0.0031240047,
-0.00044263495,
0.00039881773,
0.013826764,
0.021733336,
-0.008477818,
-0.0076014744,
0.03302844,
-0.011217206,
-0.032431226,
0.03344389,
-0.004453127,
-0.0041090804,
-0.027264042,
0.0011278874,
0.014774513,
-0.021408765,
-0.013502192,
-0.015021188,
0.016072802,
-0.011496337,
-0.030587658,
-0.0020723918,
-0.015891042,
0.008341499,
0.01552752,
-0.014943291,
-0.027108246,
0.01859148,
0.015852092,
-0.004936739,
0.02721211,
-0.018786224,
-0.004135046,
0.010172084,
0.006124672,
-0.020694705,
-0.023953408,
-0.00067470386,
0.017682679,
-0.0015733624,
-0.0023547693,
-0.015008206,
-0.000010688052,
0.019188693,
0.006527141,
0.020473996,
-0.027315972,
-0.017656712,
-0.028744088,
-0.024161134,
0.0013972821,
-0.04554393,
0.04146731,
0.009879969,
0.0015847224,
-0.005073059,
0.002903296,
-0.16098768,
0.0047874358,
0.007017245,
-0.02910761,
0.03050976,
0.027134212,
0.018539548,
-0.010542096,
0.0027020613,
0.009334688,
0.0067446046,
-0.008146755,
-0.031496458,
-0.019928716,
0.016682997,
0.015748229,
0.0040993434,
0.03931215,
0.0054495623,
-0.008185704,
-0.0016780369,
-0.022577222,
0.03453445,
-0.010366827,
0.015384709,
0.037832104,
0.00898415,
0.0053197336,
-0.014592754,
-0.019175708,
-0.012164956,
-0.013787815,
0.034352694,
0.014605736,
0.026017684,
-0.0054138596,
0.004712784,
-0.0133723635,
-0.016903706,
-0.010658942,
0.0046056756,
0.024628518,
0.0067121475,
-0.011145799,
0.009373637,
0.021668421,
-0.0025349066,
-0.029756753,
0.017111432,
0.026485069,
0.012891997,
0.0032327364,
-0.008309041,
0.0011895561,
0.036092397,
-0.0036676626,
-0.0034501995,
0.017007569,
0.013190603,
-0.023044607,
-0.020642774,
-0.0038526687,
0.013567106,
0.005222362,
0.009003625,
-0.018825172,
-0.00094044715,
0.0151120685,
-0.027238075,
0.0028026786,
-0.007919555,
-0.0046413783,
0.004242155,
-0.02427798,
0.027238075,
-0.0048036645,
0.00667969,
-0.0026549983,
0.0031110218,
-0.01345026,
-0.029497096,
0.0036189768,
-0.031029075,
-0.021863164,
-0.011983195,
-0.017799525,
-0.00478419,
0.005069813,
-0.0008795899,
0.01033437,
0.005261311,
-0.02148666,
0.028354604,
-0.013047791,
0.031496458,
0.024797294,
0.0030964161,
-0.006140901,
0.005167185,
0.00051850366,
0.0074846284,
-0.011288611,
-0.0123012755,
0.014813462,
0.03357372,
-0.010879651,
-0.0128465565,
0.023213383,
0.046920117,
0.0032181307,
-0.025706096,
-0.0025527582,
-0.0006394067,
0.025926804,
-0.014748548,
0.034119,
-0.021668421,
0.003362565,
-0.0038299486,
0.013982559,
0.072236724,
-0.01718933,
-0.0019263343,
-0.0017656713,
-0.005835803,
-0.011308086,
-0.13481419,
-0.010892633,
-0.01105492,
-0.0067770616,
0.008789408,
0.011853366,
0.004589447,
0.023706732,
-0.020188373,
0.029704822,
-0.03185998,
0.0070691765,
0.009899444,
-0.02666683,
-0.017124414,
-0.01191179,
-0.0031061533,
0.008068858,
-0.030172206,
0.044687063,
-0.0006345381,
-0.013865712,
-0.0017315912,
-0.013645004,
0.0006252067,
0.011321069,
-0.031756118,
0.019266589,
0.007698846,
-0.0002503261,
0.0076793716,
-0.02599172,
-0.012534968,
0.013995541,
-0.0043687383,
-0.0052775396,
0.025212746,
-0.019474315,
0.024693431,
-0.014774513,
-0.018020233,
-0.0034307253,
0.040973958,
0.019149743,
0.0010086072,
0.00012546733,
-0.025147833,
0.0019117286,
0.00035358054,
-0.0103927925,
-0.031626288,
-0.002163272,
-0.008763442,
-0.027419835,
0.007211988,
-0.018890087,
-0.006764079,
0.0035735369,
-0.004349264,
0.0027702213,
0.00012871306,
0.0024359121,
-0.029626925,
-0.012554442,
0.016189648,
-0.017461969,
-0.03876687,
-0.013333415,
0.012035127,
-0.024096219,
0.007523577,
0.015384709,
-0.0016569396,
0.005245082,
-0.04151924,
0.010048747,
-0.014709599,
-0.009685226,
0.017358106,
-0.007815692,
-0.009055557,
-0.0067770616,
0.025381524,
-0.00020052459,
0.028224774,
0.016540185,
-0.00740024,
-0.0039727604,
0.0060305465,
0.0011416817,
-0.0027832042,
0.03443059,
-0.0054300884,
-0.010587536,
-0.0036157311,
-0.0060954606,
-0.0119247725,
-0.022525292,
0.02210984,
0.021876147,
-0.008860813,
-0.025926804,
-0.048633855,
-0.001346162,
-0.009146437,
0.0019977402,
0.008133773,
0.0023515236,
0.014268181,
-0.011360018,
-0.015151017,
0.03533939,
0.00030530046,
0.008224652,
0.00053310936,
-0.0035086225,
-0.035365358,
-0.011671606,
0.033703547,
0.0012358075,
0.0076339315,
0.030302035,
0.033236165,
-0.013774833,
0.008354481,
0.008432378,
-0.025420472,
-0.022434412,
-0.00073474966,
-0.0065466156,
-0.0008252241,
-0.013632021,
0.008107807,
-0.044738993,
0.0058520315,
0.001710494,
-0.00404092,
-0.005826066,
0.008477818,
0.02216177,
0.020512946,
0.060032822,
-0.01100948,
-0.016059818,
-0.002658244,
0.009990323,
-0.020876465,
-0.013398329,
-0.05676114,
-0.0010678417,
0.0018825171,
-0.013210077,
0.048218403,
0.009458026,
-0.0002422118,
-0.012534968,
-0.01489136,
-0.009263283,
-0.0046056756,
0.022187736,
0.012781642,
-0.014086422,
0.021967027,
0.019733973,
0.009776106,
-0.0036838914,
-0.007192514,
-0.01276866,
-0.02035715,
0.0012179561,
-0.000015987704,
-0.022746,
-0.012969894,
0.005053585,
0.0073093595,
0.0065238955,
-0.006046775,
-0.012943928,
-0.0148394285,
-0.001536848,
-0.016189648,
0.042298213,
0.020461014,
-0.001370505,
-0.0019084829,
0.013274992,
0.027108246,
-0.009996816,
-0.01840972,
0.014436959,
-0.00839343,
0.005780626,
0.0010954302,
0.0011887447,
0.024667466,
0.024654483,
-0.00929574,
-0.0012869276,
-0.004173995,
-0.0011765732,
0.007867623,
0.019928716,
0.007594983,
0.018085148,
0.013787815,
-0.0072639193,
-0.0077183205,
0.034638315,
-0.013502192,
-0.007971486,
0.01656615,
0.032612987,
0.0119247725,
-0.008432378,
-0.018474633,
-0.007867623,
-0.024057271,
-0.0020155916,
-0.0053424537,
0.0030493531,
-0.018435685,
0.026822623,
0.0022833634,
0.0035897654,
0.009055557,
-0.010087695,
0.019279571,
-0.0077962177,
0.015332777,
-0.0025527582,
-0.0023645065,
0.01006173,
0.012982877,
-0.0071146167,
-0.0332102,
0.0050795507,
-0.0064102956,
-0.013956592,
-0.00004308185,
0.028770056,
-0.0100357635,
0.08168826,
0.022291599,
-0.027419835,
0.012840065,
-0.016397374,
0.033547755,
0.00943206,
0.0040376745,
-0.015540504,
-0.004349264,
0.016929671,
-0.05130833,
0.013632021,
-0.020486979,
-0.019331504,
0.029237438,
-0.013813781,
0.024576586,
0.0031142675,
-0.023044607,
0.006598547,
-0.003593011,
0.004206452,
0.012729711,
-0.029341301,
0.016579134,
0.02314847,
-0.007964995,
0.0063259066,
-0.006209061,
0.0132685,
-0.009587854,
-0.036326088,
0.02495309,
-0.012132498,
-0.005926683,
-0.0042713666,
-0.028017048,
0.016410356,
0.008692036,
0.010944565,
-0.005384648,
-0.0023872266,
-0.019162726,
-0.012891997,
0.0027101755,
-0.010886142,
-0.017319158,
-0.014190285
] |
Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major architectural elements of the mammalian cell nucleus. The HGPS mutation activates an aberrant cryptic splice site in LMNA pre-mRNA, leading to synthesis of a truncated lamin A protein and concomitant reduction in wild-type lamin A. Fibroblasts from individuals with HGPS have severe morphological abnormalities in nuclear envelope structure. Here we show that the cellular disease phenotype is reversible in cells from individuals with HGPS. Introduction of wild-type | [
-0.024099788,
0.029045792,
0.011310048,
-0.026826255,
-0.024579316,
0.018537244,
-0.014605101,
0.012878795,
-0.019975834,
-0.006545579,
0.0048192726,
0.005946167,
-0.016454715,
0.015769674,
0.0065695555,
-0.003231687,
0.03093651,
0.00067733554,
0.012399266,
0.014550298,
-0.020386858,
0.014399589,
0.002745307,
-0.052474238,
0.003565645,
-0.0045932084,
0.0021921352,
-0.030278869,
-0.008090349,
0.0050282106,
-0.0015995738,
-0.017811099,
0.0059221904,
-0.011104535,
-0.00013872107,
0.005038486,
0.020153943,
-0.021661038,
0.0024387506,
-0.0032059979,
0.01815362,
0.006658611,
-0.0055830944,
-0.0044562,
-0.009905712,
0.012817141,
-0.0071381405,
-0.013221316,
-0.020934893,
0.00038276738,
0.022496788,
0.0062304595,
-0.011714223,
-0.0061037266,
-0.0012741786,
-0.0064873504,
0.019496303,
0.0070559354,
-0.0062475856,
-0.0077135763,
0.0025911725,
-0.0042643882,
-0.02657964,
0.009700199,
-0.0020705403,
0.017084954,
-0.01490652,
0.0028326497,
-0.0017639839,
0.0031631826,
0.027511299,
0.033594474,
-0.024962941,
-0.030114459,
0.02188025,
-0.0051617934,
-0.01894827,
-0.00989201,
-0.025976803,
0.021208908,
0.019701816,
-0.010679809,
0.018345432,
0.018098816,
0.008008144,
-0.008090349,
-0.022990018,
0.016797237,
0.013837854,
-0.021948755,
0.012255406,
0.03225179,
-0.002632275,
0.008679486,
-0.020647174,
0.004367145,
0.0060831755,
0.018824961,
-0.01750968,
-0.02072938,
-0.026675547,
0.010392091,
-0.02026355,
-0.007371055,
-0.01605739,
-0.009138464,
0.0027692835,
0.0021253438,
0.0124883205,
-0.017304169,
-0.014646204,
0.021770643,
-0.006062624,
-0.020633474,
0.014563999,
-0.020181345,
0.023085926,
0.01797551,
0.010104374,
-0.009261772,
0.027113974,
0.0021904227,
0.018660551,
-0.009926262,
0.013899508,
0.012433518,
-0.039157018,
0.0056139217,
-0.005733804,
-0.011042882,
0.0037985595,
0.012282808,
0.0029525321,
0.010522249,
-0.012193752,
-0.0062955385,
-0.012995252,
-0.03512897,
-0.026278222,
-0.02901839,
-0.00160043,
0.03063509,
-0.02722358,
0.020838987,
-0.013598089,
0.011029181,
0.0024610143,
0.00008306138,
0.010570202,
0.012851393,
0.0152627425,
0.01327612,
0.0056927013,
-0.0022058361,
0.000102167636,
0.035402983,
-0.017071255,
0.0243053,
-0.032608014,
-0.037211496,
-0.009686498,
-0.00713129,
0.016482117,
0.018400235,
0.0031648953,
0.03173116,
-0.013351474,
0.014344785,
0.0037848586,
-0.0059187654,
-0.021839147,
0.019975834,
-0.027936025,
0.0056139217,
-0.00421301,
-0.0063297907,
-0.014714709,
0.023031121,
-0.032964233,
-0.024510812,
-0.03225179,
0.01816732,
0.008172555,
-0.015125734,
-0.008234208,
-0.007809482,
0.032032575,
-0.0042506875,
0.0038191108,
-0.008117751,
-0.012734936,
0.007158692,
-0.00042087285,
0.003966395,
-0.63396555,
-0.050117694,
0.017893305,
-0.0140844695,
0.013495333,
0.028716972,
0.0013512459,
-0.006233885,
-0.024634121,
0.029895246,
-0.023743566,
0.02981304,
0.0053501804,
-0.004603484,
-0.010522249,
-0.027826417,
-0.0058845133,
-0.00022627803,
0.018687954,
0.023866873,
-0.017742595,
-0.0031237928,
-0.0044733263,
0.010946976,
0.013618641,
0.04080112,
0.02333254,
-0.021661038,
-0.0035245426,
0.030032253,
-0.024072386,
0.025154753,
-0.016619125,
-0.0145777,
0.056611896,
-0.022880413,
-0.013043205,
0.023606557,
0.02008544,
0.03178596,
-0.026963264,
0.008282161,
0.016934246,
0.0042712386,
-0.025552077,
0.0027778465,
0.0019044175,
-0.0027179052,
0.01767409,
-0.015112033,
0.020510167,
0.024990343,
-0.022441985,
0.006501051,
-0.010535951,
0.004031474,
0.014468093,
0.0021869976,
0.030196663,
-0.015810777,
-0.005281676,
0.042828843,
-0.007816332,
0.013892657,
-0.008384918,
-0.0015079493,
-0.0076519223,
0.007192944,
-0.0049049025,
-0.012515723,
0.014372187,
0.03710189,
-0.002019162,
0.020975994,
0.02316813,
0.026949564,
-0.0056995517,
-0.0006379456,
-0.0012913047,
0.011721074,
0.0009068247,
-0.007049085,
-0.041294347,
0.00494258,
0.043486483,
-0.013481632,
-0.053570308,
0.03142974,
-0.026237119,
0.0015028116,
0.0040486,
-0.007069636,
-0.009775554,
-0.04822698,
-0.03499196,
-0.012974701,
-0.012454068,
0.00761082,
-0.004421948,
-0.01667393,
-0.0013777913,
-0.001936957,
0.02056497,
0.015660066,
0.043130264,
0.0177974,
-0.039294027,
0.0054700626,
0.026607042,
-0.023784667,
-0.011906035,
-0.0028480634,
-0.0010267071,
-0.021126704,
-0.010816818,
-0.021893952,
0.013200765,
-0.01589298,
-0.01150186,
-0.00907681,
0.007857435,
0.004685689,
0.01812622,
0.0043808455,
0.0099605145,
0.0046411613,
0.0029953474,
-0.032827225,
-0.0145914005,
0.0021835724,
0.008878148,
-0.012241705,
0.014769511,
-0.011282646,
0.029730836,
-0.018824961,
0.013584388,
0.003048438,
0.020934893,
-0.01829063,
-0.037869137,
-0.0027504447,
-0.0002558205,
-0.007069636,
-0.018715356,
-0.022825608,
-0.005555693,
-0.023099625,
-0.0057920325,
0.0019129806,
0.0043191914,
0.0064256964,
0.014303683,
0.03447133,
0.008967203,
-0.01263903,
0.0031289307,
-0.02411349,
0.0069737304,
-0.022441985,
0.0056927013,
0.015057229,
-0.0043157665,
0.011344301,
-0.009802955,
-0.009850908,
0.011495009,
0.044582553,
-0.01570117,
-0.026305623,
-0.013515884,
-0.025634281,
-0.02074308,
0.0023428446,
0.008117751,
0.017783698,
0.028059332,
-0.00075996877,
-0.01183068,
-0.009405631,
0.0020071738,
-0.008439721,
0.0030193238,
-0.011166189,
0.011597766,
0.012604778,
0.037348505,
0.0061037266,
0.021811746,
0.025209555,
-0.002180147,
0.029210202,
-0.015783375,
0.0069429036,
-0.0013795039,
-0.03499196,
0.012837692,
0.0059016393,
0.0026117237,
0.022853011,
0.011467608,
-0.032333996,
0.009206968,
-0.02024985,
0.03110092,
-0.0404997,
0.005312503,
-0.024264198,
-0.01815362,
0.005607071,
-0.011611466,
-0.0032419625,
0.0025808967,
-0.015276443,
0.0024473136,
-0.008343815,
-0.01539975,
0.011152488,
-0.011933437,
-0.010741463,
-0.0044287983,
0.016166998,
0.023236634,
0.0000036560118,
0.010583904,
0.04225341,
0.016468417,
0.030278869,
0.012734936,
-0.011556664,
0.006463374,
0.028278545,
0.00063237967,
0.025415068,
-0.009837207,
0.02445601,
0.0061379788,
-0.009028858,
0.044253733,
0.00087514153,
0.0026511136,
-0.019359294,
0.011604616,
-0.0120224925,
0.0010130063,
-0.015207939,
0.031840764,
0.0021904227,
-0.019468902,
0.022606395,
-0.021154106,
0.009912562,
-0.0070833373,
0.008323263,
-0.002949107,
-0.003067277,
0.00841917,
0.020496465,
0.034608338,
0.030854305,
0.018249527,
-0.015317545,
-0.011858082,
-0.01750968,
-0.021524029,
-0.01750968,
0.005285101,
0.0106318565,
-0.0011251819,
0.010577053,
-0.010796267,
-0.0067476663,
-0.0012305072,
-0.0697647,
0.0012519148,
0.005860537,
0.022496788,
0.014714709,
0.035211172,
0.017413775,
-0.005233723,
-0.04455515,
0.036553856,
0.009316575,
-0.029429417,
-0.018413937,
-0.022907814,
-0.013639192,
0.0067784935,
-0.0025911725,
-0.012495171,
0.024428608,
0.0066620363,
0.0014831165,
-0.0069908565,
-0.024962941,
0.01652322,
0.0065866816,
0.0105907535,
-0.0070901876,
-0.026812555,
0.00389104,
-0.008563029,
-0.0068093203,
0.025168454,
0.020359457,
-0.022058362,
-0.012097847,
0.012666432,
-0.016947946,
0.0026665272,
-0.014289982,
-0.00015531194,
-0.0055659683,
-0.02464782,
0.005233723,
-0.0075560166,
-0.009111063,
0.015769674,
0.00324025,
-0.022551592,
-0.0355948,
-0.014139272,
-0.0066038077,
0.031183125,
0.026785154,
-0.010124925,
0.006494201,
0.014933921,
0.013693995,
0.031046117,
-0.031977773,
0.03269022,
-0.016166998,
0.0066620363,
0.0069600297,
-0.0070216833,
-0.018537244,
-0.006771643,
0.028086733,
0.00542896,
-0.02366136,
-0.0038944653,
0.012536273,
0.020756781,
-0.0026990667,
0.01020713,
0.029621229,
0.010796267,
-0.014317384,
-0.0016321132,
0.0046103345,
-0.0018136494,
-0.015660066,
-0.041102536,
0.0046069096,
0.009713899,
-0.0053878576,
0.018729055,
-0.020715678,
0.03512897,
0.0025483572,
0.007487512,
-0.0049391547,
-0.002705917,
0.005768056,
0.017646689,
-0.0016637965,
0.025949402,
0.022757106,
-0.0145914005,
-0.0073573543,
-0.014687306,
-0.002315443,
0.026168615,
-0.0068778247,
0.0047096657,
-0.011145638,
0.015317545,
-0.013221316,
-0.0039150165,
-0.007309401,
0.010638706,
-0.03063509,
-0.009343977,
-0.024195693,
-0.009213819,
-0.003192297,
0.000061707324,
-0.020290952,
-0.006220184,
0.012200603,
-0.013269269,
-0.018811261,
-0.01589298,
-0.038143154,
-0.014166675,
0.0015250754,
0.021989858,
0.01668763,
0.012714385,
-0.01069351,
-0.003661551,
0.020318354,
-0.00087942305,
-0.024661522,
0.0054152594,
-0.014166675,
0.031950373,
0.015166836,
0.015084631,
-0.0049117533,
-0.010638706,
0.007987593,
0.0120224925,
-0.022291277,
0.0038670637,
-0.007261448,
-0.022825608,
-0.017194562,
0.037622523,
0.016564323,
-0.018674253,
0.00086700666,
0.009241221,
-0.03745811,
-0.027908623,
-0.023757266,
-0.023277737,
-0.0018256376,
-0.009802955,
0.00066877255,
-0.02931981,
-0.029127998,
-0.0038191108,
-0.010487997,
0.0019386697,
0.012365013,
0.014180375,
0.021565132,
0.031018715,
0.00017126057,
0.024894437,
-0.011042882,
-0.009919412,
-0.02188025,
0.015838178,
-0.011495009,
-0.002002036,
0.018715356,
0.03096391,
-0.014317384,
-0.01927709,
-0.026689248,
-0.016166998,
0.03419731,
0.0028412128,
-0.032827225,
-0.019660713,
-0.016180698,
-0.02201726,
-0.00230688,
-0.0039800955,
-0.010453745,
-0.0045075784,
0.018989373,
0.011632018,
0.013598089,
0.01587928,
-0.033402663,
0.0011628593,
-0.013981713,
-0.010501699,
0.0026511136,
-0.0034200735,
0.01911268,
-0.0073162518,
-0.016043691,
-0.0055145905,
-0.022565292,
0.01523534,
0.002723043,
0.030881707,
0.031977773,
0.03970505,
-0.014454392,
0.027675709,
0.03030627,
0.019235987,
-0.0035039913,
-0.0037677325,
-0.0019917605,
-0.02544247,
0.007672474,
0.0072340467,
-0.009035707,
0.021482926,
-0.044500347,
0.01733157,
0.019948432,
-0.001283598,
-0.007419008,
0.021770643,
-0.048500992,
-0.027072871,
-0.004600059,
-0.005017935,
0.0069737304,
-0.054529365,
-0.015057229,
0.007693025,
0.005655024,
-0.0038465124,
-0.01863315,
0.019044176,
-0.0049014776,
0.024716325,
-0.0016894855,
0.022085764,
0.00064822123,
-0.022811908,
0.016180698,
0.017400075,
-0.00066577544,
-0.01507093,
0.01602999,
-0.02316813,
-0.008494524,
0.013461081,
-0.0015344947,
-0.0102961855,
-0.009419331,
-0.016413612,
-0.022400882,
-0.018071415,
-0.026017906,
-0.0015019552,
-0.04600744,
0.0005030779,
0.008645234,
-0.021017097,
0.03060769,
-0.018222125,
-0.019756619,
0.010748314,
-0.004439074,
0.0050110845,
-0.035677,
0.026470033,
0.031018715,
-0.023387343,
-0.028223742,
0.0105907535,
0.026839957,
0.015687468,
0.033320457,
0.0007458398,
-0.0117690265,
-0.018222125,
-0.016468417,
0.019249689,
-0.017852202,
-0.04159577,
0.0045829327,
0.0061037266,
-0.001060103,
-0.005655024,
-0.012392415,
-0.028470358,
0.011899184,
-0.0022606396,
0.010172877,
0.009816656,
-0.0044562,
-0.017358972,
0.0126116285,
-0.015358648,
0.015454554,
0.0015901544,
-0.012132099,
-0.011378553,
-0.028251143,
0.025647983,
0.016934246,
-0.0114333555,
0.033484865,
-0.019331893,
0.008556178,
-0.00005153873,
-0.0077135763,
0.022729702,
0.004394546,
-0.00713129,
0.0404997,
-0.012782889,
-0.02460672,
0.008220508,
0.026442632,
0.030032253,
0.00065892504,
0.0019575083,
-0.016742432,
-0.009371378,
-0.012084146,
0.0075217644,
0.022880413,
-0.0063263653,
0.012180052,
-0.01733157,
0.009357678,
-0.029676031,
-0.028963588,
0.020359457,
-0.05000809,
-0.023524351,
-0.014728409,
0.01861945,
0.0033652703,
0.018770158,
-0.0102961855,
0.005230298,
0.051295966,
-0.013098008,
0.008843896,
0.0018992798,
-0.0021955606,
-0.011926586,
0.01977032,
-0.0041993093,
-0.0025055422,
0.008727439,
-0.015016126,
-0.016427314,
-0.02024985,
0.0032351122,
0.025702786,
0.01361179,
-0.014468093,
0.007953341,
-0.010796267,
0.007432709,
-0.012789739,
-0.006206483,
0.015975187,
0.0010695222,
0.016906844,
-0.01020028,
-0.011481308,
0.0069292025,
-0.02366136,
-0.012269108,
0.022455687,
-0.023058522,
-0.008446571,
0.0077889306,
0.0032813526,
0.008521926,
-0.017605586,
-0.022866711,
-0.016235502,
-0.012111547,
-0.007062786,
0.0024421758,
-0.0037848586,
-0.010255083,
0.006977156,
-0.0006923209,
0.036964882,
-0.027264683,
0.0032625138,
0.002897729,
-0.020441663,
-0.031840764,
-0.004586358,
-0.01004957,
0.037019685,
0.023633959,
-0.015112033,
-0.019592209,
-0.015851878,
-0.03745811,
-0.022058362,
0.02234608,
-0.0048192726,
0.007850585,
0.038280163,
-0.002406211,
0.008638383,
0.008193105,
0.007062786,
0.0023051673,
-0.019496303,
0.009597442,
-0.011282646,
0.0091590155,
-0.0028120985,
-0.01845504,
-0.024825932,
0.018249527,
0.028388152,
-0.019030474,
-0.00007246463,
-0.0027590077,
0.0032368249,
-0.014563999,
0.0013127123,
0.011871783,
-0.0082753105,
0.014372187,
-0.01507093,
-0.016372511,
-0.004504153,
-0.0014805476,
-0.01927709,
0.009378229,
0.008199956,
0.0062955385,
0.0060317973,
0.0008391768,
-0.027264683,
0.017564485,
0.008158853,
0.03808835,
0.009570041,
0.013378876,
0.011974539,
0.027908623,
-0.001902705,
0.005202896,
0.0010917862,
-0.015742272,
-0.026209718,
0.01555046,
-0.014166675,
-0.0076313713,
0.0058571114,
0.013419978,
-0.036088027,
-0.03175856,
-0.007480662,
-0.021236312,
-0.024976641,
0.041239545,
-0.021291114,
0.0017502831,
-0.016605426,
-0.00014514333,
-0.0057098274,
0.016810937,
0.01474211,
0.021304814,
-0.008186256,
0.01085792,
0.0021561706,
0.004034899,
0.000048702226,
0.008535627,
-0.0056961267,
-0.000108215274,
0.0047028153,
0.17745335,
0.005442661,
0.0028069608,
-0.00761767,
-0.0028497758,
-0.013796751,
0.019482603,
0.0106318565,
0.0010738038,
0.017852202,
0.014495495,
-0.023031121,
0.0020260126,
0.009878309,
0.019496303,
-0.026648145,
-0.025894599,
-0.0033806837,
-0.019359294,
-0.033073843,
0.031073518,
0.010385241,
0.018811261,
-0.019400397,
0.014399589,
-0.010357839,
-0.028442957,
0.0021082177,
0.016317707,
0.014796914,
-0.011036031,
-0.01426258,
-0.0060866005,
-0.016906844,
0.008193105,
0.01150186,
-0.0028429255,
0.009974216,
-0.0129061965,
0.021647336,
0.000607975,
0.015180537,
-0.0068606986,
-0.00014599964,
-0.006429122,
-0.008398619,
-0.002484991,
-0.030333672,
-0.006463374,
0.013735098,
-0.05622827,
0.0025072547,
0.00059127714,
0.02445601,
-0.010022169,
-0.0014522896,
-0.025922,
0.013878956,
-0.008199956,
0.011220993,
-0.0004769607,
0.022387182,
-0.011323749,
0.01683834,
-0.000040808183,
0.046582874,
-0.0011551526,
-0.015358648,
0.007994443,
-0.02411349,
0.00068204524,
-0.016468417,
-0.008631533,
0.011481308,
-0.0033738331,
-0.019249689,
0.031073518,
0.0075423154,
-0.0066962885,
0.019235987,
0.026702948,
0.0016826352,
-0.028168939,
-0.0045007276,
-0.016591724,
-0.055296615,
0.015934084,
0.027662007,
-0.024414906,
-0.03822536,
0.028552562,
-0.01635881,
-0.01602999,
0.0047404924,
0.0039629694,
0.010241382,
0.0020773907,
0.010659258,
-0.008309563,
0.0027521574,
-0.026154915,
0.062475856,
-0.010611305,
0.000071822404,
0.0024301875,
0.0042815143,
-0.0016809225,
0.008282161,
0.001359809,
-0.01749598,
-0.009734451,
-0.013495333,
0.0048569497,
-0.016166998,
-0.014029666,
0.031648953,
0.016783535,
-0.019523704,
0.033649277,
0.0074943625,
0.006024947,
-0.020934893,
0.004322617,
0.027662007,
-0.00444935,
-0.012180052,
-0.011364851,
0.0088644475,
-0.018852364,
-0.035868812,
-0.01344738,
-0.00097276,
0.005459787,
-0.011200441,
-0.008398619,
-0.021962456,
-0.0072340467,
-0.005541992,
-0.019249689,
0.011563513,
-0.008405468,
-0.0029028666,
0.0242779,
0.0027521574,
-0.009179567,
-0.009350827,
0.011268945,
0.025469871,
-0.018509842,
-0.018098816,
-0.02608641,
-0.017084954,
0.012180052,
0.005959868,
0.01589298,
-0.019071577,
-0.011912885,
-0.014728409,
0.019400397,
-0.0044527748,
-0.027237281,
0.026045308,
0.010953826,
0.00036114574,
-0.005182345,
-0.0082753105,
-0.17471318,
-0.0039115916,
-0.01960591,
-0.023935378,
0.005648174,
0.015084631,
0.021976156,
-0.0077067255,
-0.005117266,
0.01605739,
0.021702139,
0.012693834,
-0.022798207,
-0.027196178,
-0.000197913,
0.017427476,
-0.031868167,
0.039321426,
0.027771614,
-0.014111871,
0.004028049,
-0.034635738,
0.023688762,
0.0011971114,
0.0030415878,
-0.005069313,
0.028716972,
-0.006648335,
-0.022469386,
-0.01556416,
-0.0055351416,
-0.0054186843,
0.034252115,
-0.008206806,
0.008789092,
-0.010782566,
-0.0119813895,
0.0018735906,
-0.00039882306,
-0.0073162518,
0.014865418,
0.016427314,
0.02171584,
0.0053364793,
-0.013036354,
0.023524351,
0.0003669258,
-0.010029019,
0.02608641,
-0.0046411613,
0.028305948,
-0.016166998,
0.03466314,
0.026771452,
0.0075491657,
-0.009768703,
0.0001427885,
0.010501699,
-0.0017725469,
-0.010878472,
-0.020304654,
-0.007336803,
0.035512593,
-0.006429122,
0.009755002,
-0.027497597,
-0.0060043954,
-0.005319353,
-0.023565454,
0.0052953768,
-0.027689409,
-0.01313226,
0.011440206,
-0.018427638,
0.035293378,
0.024497112,
-0.017948108,
0.018441338,
-0.023907976,
-0.0028257994,
-0.023688762,
0.015632665,
-0.016934246,
-0.02074308,
-0.012502022,
-0.020359457,
0.012125248,
0.01912638,
0.010323587,
-0.024825932,
0.009768703,
-0.01020028,
0.019016774,
-0.009912562,
0.039979067,
0.04260963,
-0.012700684,
-0.0024986917,
-0.0016578024,
-0.014331085,
0.0066997134,
-0.010487997,
-0.010111224,
-0.00041059722,
0.03597842,
0.0026254246,
-0.0077067255,
0.019523704,
0.05409094,
-0.015440853,
0.0039150165,
-0.0029371188,
0.015577861,
0.0128650945,
-0.007912238,
0.0023702462,
-0.007501213,
-0.0020037487,
0.0062441602,
-0.0024130614,
0.04893942,
-0.0063058143,
0.0014257443,
0.0002723043,
0.013577538,
0.00007594336,
-0.12210194,
-0.018345432,
0.0035022786,
0.008795943,
0.0050487616,
0.0151394345,
0.014975024,
0.017317869,
-0.008563029,
0.02478483,
-0.02655224,
-0.025634281,
0.0010815106,
0.0058399853,
0.012166351,
-0.0111798905,
0.014687306,
-0.012844543,
-0.010659258,
0.03712929,
-0.018811261,
0.0053399047,
-0.0060831755,
-0.013050055,
-0.012001941,
-0.004891202,
-0.027771614,
0.026017906,
0.016331408,
0.0007389894,
0.011453907,
-0.014961324,
0.02056497,
0.013926909,
-0.020880088,
-0.016208101,
0.00050992833,
-0.000049585287,
0.022387182,
-0.023277737,
-0.00396982,
0.0054323855,
0.014235179,
0.0023822344,
0.012056745,
-0.010768864,
-0.008789092,
0.02399018,
0.018030314,
-0.010227681,
-0.028799178,
-0.03625244,
-0.019181184,
-0.014563999,
-0.003158045,
-0.029867843,
-0.0032025727,
0.041677974,
-0.0100838225,
-0.004466476,
-0.020469064,
0.008193105,
-0.011789578,
-0.023524351,
0.016413612,
-0.010289335,
-0.027689409,
-0.048829813,
0.046363663,
-0.005603646,
-0.006915502,
0.0047404924,
-0.019811423,
0.004682264,
-0.014344785,
0.019372996,
0.0065866816,
-0.004586358,
0.012830842,
-0.009974216,
-0.012097847,
-0.014879119,
0.020058038,
0.0034509005,
0.0059701437,
0.022757106,
0.011707373,
0.008631533,
0.0059221904,
0.0025175305,
0.011775876,
0.025853496,
-0.0038156856,
-0.006206483,
-0.025990505,
0.016769836,
-0.014029666,
-0.002962808,
0.03288203,
0.014659905,
-0.034717944,
-0.006977156,
-0.0631335,
0.021592533,
0.014728409,
0.0036409998,
0.008193105,
-0.028607367,
-0.015166836,
-0.018318031,
0.002197273,
0.005216597,
-0.019372996,
0.0072203455,
-0.010994929,
-0.017057553,
-0.010385241,
-0.013981713,
0.039184418,
0.0013161375,
0.026990665,
0.039951667,
0.0051583685,
0.017578185,
-0.015413451,
0.014468093,
0.008090349,
-0.0061208527,
-0.012995252,
0.025086248,
0.010741463,
-0.019756619,
0.00080963434,
-0.038883,
-0.0016655091,
0.0054323855,
-0.007011408,
-0.027429093,
0.012358163,
-0.00065207464,
0.034717944,
0.04967927,
-0.008700037,
-0.019674415,
0.016893143,
0.016769836,
-0.011358001,
0.0046891146,
-0.032635413,
0.012502022,
0.027881222,
0.0020482764,
0.055981655,
0.006096876,
0.0033036163,
-0.026826255,
-0.020989696,
0.0058434107,
0.004185608,
0.003214561,
0.0072545977,
-0.008227358,
0.01797551,
0.009775554,
0.006367468,
-0.0014925359,
-0.001637251,
-0.0134131275,
-0.03258061,
0.010659258,
-0.019825123,
-0.015632665,
-0.029182801,
0.006014671,
0.023935378,
0.013646042,
0.006220184,
0.0059906947,
-0.009378229,
-0.009049408,
-0.009296024,
0.00047225103,
0.011775876,
0.0003129787,
-0.009830357,
0.009967365,
0.019496303,
0.0036512753,
-0.003127218,
0.017208261,
-0.0019146932,
0.009433032,
-0.008405468,
0.0031220801,
0.012769188,
0.020537568,
0.00324025,
0.0112620955,
0.013509034,
0.011851232,
0.023072224,
0.026017906,
0.004308916,
-0.004031474,
-0.0021869976,
-0.014194076,
-0.002015737,
0.03811575,
-0.022592695,
-0.044116724,
0.03515637,
-0.013406278,
0.026017906,
0.0069257775,
0.0023308564,
0.017756296,
-0.023044823,
0.013995414,
0.014481794,
0.00461376,
-0.0066997134,
0.020332055,
0.029456818,
-0.008158853,
0.0140022645,
-0.002462727,
0.017221963,
-0.012837692,
0.040088676,
-0.033457465,
0.0030021977,
-0.029073194,
-0.0001198824,
-0.010768864,
-0.02901839,
0.0015430577,
0.0024730025,
-0.008782242,
0.0066860127,
0.016153296,
-0.02833335,
0.084561616,
0.011399103,
0.0017622713,
0.004634311,
-0.037978746,
0.00065721245,
-0.0067476663,
-0.00153792,
-0.038608983,
-0.02608641,
0.015016126,
-0.022277575,
0.023798369,
-0.027072871,
-0.022578994,
0.011090835,
0.007597119,
0.034416523,
-0.020866388,
-0.01263218,
0.05055612,
-0.013228167,
0.017920706,
0.0042849393,
-0.022318678,
0.01798921,
0.038663786,
0.00778208,
0.021839147,
-0.0023000294,
0.015797075,
-0.006251011,
-0.016098494,
-0.007905388,
0.010145476,
-0.033484865,
0.004685689,
-0.009700199,
0.033430062,
0.0007749541,
-0.005624197,
-0.00097190373,
-0.015016126,
-0.016262904,
0.003983521,
-0.019921029,
-0.007884837,
-0.012549975,
-0.0063743186
] |
Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis. | [
-0.01989877,
-0.012738626,
0.016499178,
-0.011550738,
-0.012784567,
-0.0030944163,
0.016446676,
-0.00052872516,
-0.018126782,
-0.0179824,
0.023534628,
-0.012423606,
-0.0026399342,
-0.00052954553,
-0.021408243,
-0.0016464724,
0.039009992,
0.000051785533,
-0.0004557127,
0.00663183,
-0.01715547,
0.025030974,
0.0010254561,
-0.030136924,
0.008013325,
0.007941132,
0.00013054056,
-0.042606473,
-0.005647392,
-0.004200268,
0.015147218,
-0.0065497933,
0.0044430965,
0.0057228655,
-0.0016948739,
-0.010113458,
0.0057655247,
-0.028483069,
0.019321235,
-0.00057097396,
0.018914333,
0.011924825,
-0.0012371102,
0.017352358,
-0.008302093,
0.00089255703,
0.0031649678,
-0.015449112,
0.001032019,
0.024650324,
0.009056829,
0.0038819667,
-0.038379952,
-0.016984835,
-0.027800526,
0.011045393,
0.0016440112,
0.016000398,
0.0029746431,
-0.040768854,
0.01766738,
-0.0006800825,
-0.027459254,
0.026094167,
0.008315219,
0.013637746,
-0.0034881916,
0.009096206,
0.015869139,
-0.014937204,
0.037041117,
0.016853577,
-0.027380498,
0.008905881,
0.02722299,
-0.022130163,
0.006310247,
0.00861055,
-0.0049156267,
-0.0002660033,
0.024794709,
-0.022681449,
0.0003648573,
0.03478347,
0.016512305,
-0.0028335403,
-0.007402973,
0.0052601798,
0.020988215,
0.012613931,
0.021959528,
0.016604185,
0.024309052,
0.031292,
-0.003891811,
0.016630437,
-0.002034505,
0.022733953,
-0.005342216,
-0.011458857,
-0.028351812,
0.025595386,
-0.0032273156,
-0.012902699,
0.0035472577,
0.010389101,
-0.022786455,
-0.012607368,
0.03192204,
-0.010284094,
-0.019767513,
0.028299307,
-0.003078009,
-0.043236513,
-0.017641127,
0.0049911,
0.009969074,
0.006877939,
-0.017995525,
-0.00089337735,
0.010645055,
0.022786455,
0.008203649,
0.00023913637,
0.03221081,
0.024269676,
0.02668483,
-0.013821508,
-0.011524486,
-0.01627604,
-0.016669815,
-0.0005398001,
0.017299855,
0.03570228,
-0.021355739,
0.0141102765,
-0.0029697209,
-0.012758315,
-0.015882265,
-0.029323123,
0.00022375453,
0.025424749,
-0.036568586,
0.0044430965,
-0.021985779,
0.04210769,
0.01614478,
0.022799581,
0.01050067,
0.0100084515,
-0.006297121,
-0.0049812556,
0.005384875,
-0.019413115,
0.013677124,
0.015435986,
0.022025157,
0.017654253,
-0.01697171,
-0.00063660316,
0.0183893,
-0.018494306,
-0.010789439,
0.005811465,
-0.003655546,
0.026067914,
0.014595932,
-0.0063791573,
0.005411127,
-0.008735245,
0.00048073384,
0.0149634555,
-0.014294038,
0.01013971,
-0.022222044,
0.019859394,
-0.011905136,
0.014372793,
-0.0009672102,
0.013079898,
-0.015567244,
-0.009220902,
0.008013325,
0.017234227,
-0.0024939093,
-0.0036391388,
0.016735444,
-0.034625962,
-0.0043348083,
-0.01517347,
-0.0071929595,
-0.0011288221,
-0.017628001,
-0.021618256,
-0.6388608,
-0.0064710383,
0.0328671,
-0.0041247946,
-0.006595734,
0.027931783,
0.022681449,
0.0020902897,
0.008558047,
0.021683885,
-0.016643563,
0.018402426,
0.0036457016,
-0.028666832,
-0.011386665,
-0.020515686,
-0.010113458,
-0.02497847,
0.021185104,
0.0050796997,
-0.016919205,
0.02576602,
0.005896783,
0.023285238,
0.013020832,
0.00892557,
0.01854681,
-0.010028141,
-0.0086302385,
0.018730571,
-0.0044759107,
0.025477253,
-0.006261025,
0.0027433003,
0.05326465,
0.007619549,
0.0056802067,
0.014648436,
-0.016932331,
0.044365335,
-0.03533476,
0.0027367373,
0.028903097,
-0.0061199223,
-0.03331338,
-0.0006644956,
0.00544066,
0.013650872,
0.006382439,
-0.0262123,
0.0012108586,
0.016997961,
-0.03646358,
0.01119634,
0.017404862,
0.013965892,
0.028351812,
-0.021618256,
0.00544066,
0.017207975,
0.014556555,
0.014346542,
-0.011340724,
-0.0037507084,
0.0018359766,
0.012147963,
-0.000836362,
0.019426242,
-0.009857505,
0.0042232387,
0.015632873,
0.020673195,
-0.013572117,
0.02003003,
0.032263312,
0.0067794956,
0.0043151192,
0.014582806,
-0.030871972,
-0.0014520459,
-0.013887137,
0.0027876,
-0.026028538,
0.0072651515,
0.004013225,
-0.018678067,
0.0010517078,
0.017733008,
0.008689305,
0.01432029,
0.002999254,
0.009220902,
-0.031738278,
-0.023705265,
-0.038274944,
0.010618803,
-0.016932331,
-0.0017785511,
0.013060209,
-0.030583203,
-0.0108616315,
-0.0101790875,
0.0057523986,
-0.016551683,
0.019885644,
0.0037080494,
-0.014714065,
0.020016903,
0.031974543,
-0.013874011,
-0.004918908,
-0.013926514,
-0.02169701,
0.00791488,
-0.014215283,
-0.022222044,
0.038852483,
-0.0034225623,
0.002913936,
0.0022248295,
0.029244369,
0.0036457016,
0.013053646,
-0.0064579127,
0.018533684,
0.022720827,
0.0039147814,
-0.015856013,
-0.031134488,
-0.0065071345,
0.020305673,
0.000033814416,
0.0066219857,
-0.016958583,
0.019557498,
0.027380498,
0.02801054,
-0.008439914,
0.015252224,
-0.029086858,
-0.010474419,
-0.0032650523,
0.009772187,
0.0024200764,
0.0078098737,
0.0035899167,
-0.0020902897,
0.0027318152,
0.022195794,
-0.0044070003,
-0.010933824,
-0.00000804983,
-0.010106896,
0.015029085,
0.025962908,
-0.01119634,
-0.023692138,
-0.0032683339,
-0.005427534,
-0.0016062745,
0.007166708,
0.024427185,
-0.017522994,
0.002052553,
-0.019754387,
-0.019544374,
0.014937204,
0.022589568,
-0.008558047,
-0.021565752,
0.0015734598,
-0.009601551,
-0.011636056,
0.014937204,
-0.007455476,
0.018349921,
0.004728583,
-0.019321235,
-0.0013913389,
-0.014189031,
0.0011411275,
-0.004669517,
-0.023902152,
0.012843633,
0.051322028,
0.017824888,
0.0033831848,
0.026028538,
0.0025300053,
0.02214329,
-0.025109729,
0.039114997,
-0.026343558,
0.026553571,
-0.0058081835,
-0.057071146,
0.022418931,
0.020161288,
0.010369413,
0.02690797,
0.015160344,
-0.030871972,
0.010933824,
-0.01971501,
0.020318799,
-0.03276209,
0.015540993,
-0.019255605,
-0.0129158255,
-0.012325162,
0.008105205,
0.010979764,
0.0073964098,
-0.0022888181,
0.0039377515,
0.011964202,
-0.004462785,
0.015068462,
0.0061166408,
-0.020856958,
0.007704867,
0.0042101126,
0.0021116193,
0.00009536742,
0.0024184356,
0.03979754,
0.00089255703,
0.024466563,
-0.007147019,
-0.012239845,
-0.0028466661,
0.008170835,
-0.023547754,
0.01917685,
0.008433351,
0.008098642,
-0.004275742,
-0.0034061552,
0.012338288,
0.016262913,
0.0076786154,
-0.0014339979,
0.02913936,
0.01690608,
-0.0045874803,
-0.020358175,
0.0029401877,
0.0017769104,
-0.03914125,
0.009759061,
-0.007087953,
0.019925022,
-0.021841396,
-0.00023277855,
0.012974891,
0.00766549,
0.013624621,
-0.015947893,
0.027380498,
0.026671704,
0.012003579,
0.0021838113,
-0.024637198,
-0.019150598,
-0.011852632,
-0.0094965445,
0.027196737,
-0.010802565,
0.006982946,
-0.0057458356,
-0.019728135,
-0.015869139,
-0.0058803754,
-0.035150994,
0.028115546,
0.0051682987,
0.011130711,
-0.0020574753,
0.025752895,
0.005312683,
-0.002041068,
-0.022182668,
0.035781037,
0.014149654,
-0.0047712424,
-0.027144235,
-0.028666832,
0.0047023315,
0.0048368713,
-0.0032781782,
0.011662307,
-0.008551484,
-0.0026973598,
0.0050501665,
-0.014044647,
0.015435986,
0.022720827,
-0.010441604,
0.0091487095,
0.0019344204,
0.007783622,
0.013690249,
-0.028141798,
-0.0025792273,
0.036568586,
-0.00055087503,
0.0054734745,
-0.027459254,
0.005217521,
-0.0051387656,
0.020751951,
-0.005476756,
0.012285785,
-0.007402973,
0.010940386,
0.005165017,
-0.018113658,
0.017011087,
0.029218117,
-0.0065497933,
-0.020266294,
-0.030425694,
-0.011458857,
-0.0037572712,
0.025451,
0.0147928195,
0.0017293292,
0.014897827,
0.00004447916,
0.0093193455,
-0.013611495,
-0.004262616,
0.009844379,
0.006831999,
-0.0006636752,
0.025175357,
0.0056736437,
-0.0187962,
0.030793216,
-0.0089780735,
0.0032831004,
-0.043892805,
-0.013453985,
0.007475165,
0.025542881,
0.008203649,
0.014766568,
0.021093223,
0.007987073,
-0.00047991346,
0.027590513,
0.03494098,
0.0016866702,
-0.035177246,
0.006996072,
-0.01384776,
-0.0013289911,
0.00035173146,
-0.032473326,
-0.029716898,
0.004997663,
-0.0047023315,
0.015029085,
0.0040099435,
0.026356684,
0.026579823,
0.00035234672,
-0.0149634555,
-0.009010888,
-0.0003831104,
-0.0060247597,
0.014464674,
-0.02239268,
-0.0058705313,
0.007212648,
-0.021657633,
-0.0044299704,
0.007626112,
0.0045316955,
0.004377467,
-0.00045940434,
-0.01602665,
0.018402426,
-0.018625565,
-0.022510814,
-0.0059394417,
0.038012426,
-0.014385919,
0.0012609009,
-0.026881717,
0.0084661655,
-0.017654253,
-0.02239268,
0.010074081,
0.006389002,
-0.038904984,
-0.015540993,
0.013834634,
0.0018244915,
0.027853029,
0.0086368015,
-0.0063430616,
0.016958583,
0.012443295,
-0.02090946,
-0.01980689,
-0.0070551382,
-0.0043577785,
0.01794302,
-0.018205538,
0.0044759107,
-0.019308109,
-0.015383483,
-0.02255019,
0.0043184008,
-0.016328543,
0.039587528,
-0.004925471,
-0.01987252,
-0.0046465467,
-0.0070223236,
0.017339233,
0.028246805,
0.011229155,
-0.00211326,
0.008485855,
-0.0414514,
-0.026343558,
-0.012075772,
0.0040394766,
0.017614875,
0.011767314,
-0.015081588,
-0.009417789,
0.009102769,
-0.019137472,
-0.0017654253,
0.011504797,
0.010159399,
0.024991596,
0.0026940783,
0.029375626,
0.005647392,
-0.007540794,
-0.014845323,
-0.009719684,
0.032447074,
0.026041664,
-0.024177795,
0.012738626,
-0.010389101,
0.01256799,
-0.01876995,
-0.0047384277,
-0.013007706,
0.033602145,
0.0082955295,
-0.037119873,
-0.03643733,
-0.0057228655,
-0.03908875,
0.015685378,
0.006297121,
-0.01326366,
-0.01917685,
-0.010953512,
-0.0035472577,
-0.018835578,
0.028771838,
-0.034862228,
0.013289912,
0.0021756077,
-0.008131457,
-0.0052995575,
0.012968329,
-0.009378412,
-0.03977129,
-0.014307164,
-0.016302291,
-0.0289556,
-0.002016457,
-0.0039082184,
0.035649776,
0.03165952,
0.03494098,
0.0154753635,
0.011655744,
0.012036393,
0.0043282453,
0.024414059,
0.0041576093,
0.022117037,
-0.02882434,
0.022195794,
-0.004462785,
-0.007790185,
0.03929876,
-0.004761398,
0.013053646,
-0.00035419254,
-0.004032914,
-0.017654253,
-0.0076064235,
-0.038773727,
-0.015015959,
0.03680485,
-0.021841396,
0.017273603,
-0.042658973,
-0.020240042,
0.035203498,
0.01933436,
0.0014947049,
-0.027958035,
0.023889026,
-0.039955053,
0.00883369,
0.004899219,
-0.004082136,
-0.027065478,
-0.022537064,
0.0024479688,
0.0054439413,
-0.0036391388,
-0.00903714,
0.022038283,
-0.011288221,
-0.03396967,
0.0039115,
-0.006349624,
-0.011386665,
0.013276786,
-0.010841942,
-0.016394172,
-0.030031918,
-0.01665669,
-0.02264207,
-0.02419092,
0.009608114,
0.0007411997,
-0.018061154,
0.01744424,
-0.000986899,
-0.018153034,
0.030556953,
-0.0036030426,
0.021933276,
-0.008472729,
0.021592004,
0.021237606,
0.0019524684,
-0.011675433,
-0.006982946,
-0.014609058,
0.0043348083,
0.028614327,
-0.0058770943,
0.024558444,
-0.03696236,
-0.023377119,
0.01580351,
-0.017168596,
-0.021276984,
0.039587528,
-0.008958384,
-0.0036719532,
-0.009568736,
-0.013900263,
-0.016171033,
0.014241534,
-0.0029713616,
-0.011091334,
0.012174215,
0.0032584893,
-0.012784567,
0.024466563,
0.0063791573,
0.015068462,
-0.007455476,
-0.013480236,
-0.008846815,
-0.00065260025,
-0.026251677,
0.0060181967,
-0.0003295816,
0.021263858,
0.00469905,
0.019150598,
0.009135583,
-0.0110388305,
0.0081248935,
-0.004252772,
-0.0011165167,
0.03633232,
-0.0035275691,
-0.023889026,
-0.0034652213,
-0.0035669466,
0.036909856,
-0.010855068,
-0.01045473,
-0.002295381,
-0.026251677,
-0.011163525,
0.01926873,
0.006283995,
-0.029296871,
0.0058213095,
-0.022182668,
0.007166708,
-0.041871425,
-0.005506289,
0.022103911,
-0.0073439064,
0.012384228,
-0.020069407,
0.0035078803,
-0.0017539401,
0.0031551234,
0.0074292244,
-0.013375229,
0.02535912,
-0.029323123,
0.011498234,
-0.014687813,
0.017457366,
-0.008170835,
0.008735245,
-0.020253168,
-0.008111768,
0.015042211,
-0.02850932,
-0.04512663,
-0.0154753635,
0.00022683089,
0.046360463,
0.029375626,
0.015724754,
0.011393228,
0.0060083526,
0.009142146,
-0.0013814945,
0.014189031,
0.0021116193,
-0.0086302385,
0.0037408639,
0.006123204,
-0.015068462,
-0.010631929,
-0.02403341,
-0.0030862128,
0.027879281,
-0.01326366,
0.0005242132,
-0.023469,
0.021119474,
-0.007147019,
-0.020161288,
-0.014385919,
-0.013755878,
-0.022274548,
0.010389101,
0.009345597,
-0.023665886,
-0.023180231,
0.018363047,
-0.004206831,
-0.012758315,
-0.027984288,
-0.0006472679,
0.012161089,
-0.019885644,
-0.03908875,
-0.016446676,
-0.026251677,
0.020843832,
0.009647491,
-0.010435042,
-0.0017391735,
-0.006566201,
-0.026501067,
-0.022681449,
0.003370059,
0.005683488,
-0.000038659695,
0.01908497,
-0.0038425892,
-0.011537612,
0.026934221,
0.023167105,
-0.0028204145,
-0.009739372,
0.004075573,
-0.0033290407,
0.015856013,
0.013742753,
0.0032945855,
-0.025017848,
0.022353303,
-0.03415343,
-0.0059460048,
0.020633819,
-0.017404862,
0.027853029,
-0.023416495,
0.012712374,
0.022602694,
0.008111768,
0.040585093,
-0.0068910653,
-0.024204046,
0.018533684,
-0.0029533138,
-0.005437379,
-0.02245831,
0.011117585,
0.002021379,
0.021237606,
-0.049589418,
-0.024650324,
-0.0058081835,
-0.0068451245,
0.029585639,
0.03864247,
-0.0059722564,
0.00483359,
0.007462039,
-0.010874758,
-0.029218117,
-0.0028614327,
-0.019990653,
0.02864058,
0.021185104,
0.010467856,
-0.0053094015,
0.002659623,
0.014766568,
-0.033234622,
0.019413115,
0.003091135,
-0.016879829,
-0.021972654,
-0.0054964446,
-0.007750808,
0.004003381,
-0.005788495,
-0.010855068,
-0.00008336958,
-0.0042363643,
-0.010999452,
-0.022628946,
-0.012876447,
-0.004446378,
0.011990453,
-0.012889573,
-0.018966837,
-0.017037338,
-0.01141948,
-0.009949385,
0.019925022,
0.17620125,
-0.009463729,
0.016801072,
0.00073914876,
0.008728683,
0.016866703,
0.0068976283,
-0.0105269225,
-0.001126361,
0.019189976,
-0.013276786,
0.024072787,
-0.01162293,
-0.0024020285,
-0.00712733,
-0.028903097,
-0.028036792,
0.0026809524,
-0.006982946,
-0.01674857,
0.00048770694,
-0.01785114,
0.016617311,
-0.014189031,
0.036201064,
0.0063200914,
-0.035492267,
-0.0056802067,
0.0067794956,
0.019623129,
-0.018664943,
0.009470292,
-0.004695769,
0.0055030077,
0.017614875,
0.011071645,
-0.028168049,
0.007337344,
0.0035899167,
-0.015646,
-0.0017408143,
-0.0027154079,
0.01288301,
0.0055194153,
-0.005630985,
0.006825436,
0.012154526,
-0.015383483,
-0.0019508278,
0.021185104,
-0.053868443,
0.015908517,
0.028693084,
0.02526724,
0.0041937055,
-0.013926514,
0.028850593,
-0.002223189,
0.005046885,
0.03567603,
-0.026356684,
0.009588425,
-0.005762243,
0.031265747,
-0.0037802414,
0.027853029,
-0.00422652,
0.003891811,
0.017142344,
0.00027871897,
-0.0051945504,
-0.00035624346,
-0.015501616,
-0.016696066,
0.014766568,
-0.013834634,
0.030189428,
0.02801054,
0.0033799035,
0.01926873,
0.009962511,
-0.0011854273,
-0.0041740164,
0.013440859,
-0.027275492,
-0.032000795,
0.027800526,
0.003498036,
-0.022038283,
-0.022904588,
0.009693432,
0.0022920996,
-0.019216228,
-0.012128275,
-0.016958583,
-0.02832556,
0.0064644753,
-0.005539104,
-0.021303236,
0.014399045,
-0.018717445,
0.038878735,
-0.006162581,
0.0227077,
-0.015278476,
-0.0066285483,
0.008413662,
0.016945457,
0.018612439,
0.0033963106,
0.0001693028,
-0.01724735,
0.003333963,
-0.011636056,
-0.0100018885,
0.017746134,
0.016735444,
-0.035492267,
0.013795257,
-0.018586187,
-0.034074675,
-0.004183861,
-0.0029926912,
0.004774524,
-0.004682643,
-0.0060739815,
-0.0147928195,
-0.021434493,
-0.00030989284,
-0.029165613,
0.00021801198,
-0.026934221,
-0.010684432,
0.01747049,
0.007160145,
-0.0015431064,
0.01582976,
0.015554119,
0.005919753,
0.034862228,
-0.007619549,
0.003668672,
0.023350867,
0.00892557,
0.018586187,
-0.009168399,
0.0227077,
0.007245463,
0.0025119574,
0.009942822,
-0.021080097,
-0.019032465,
-0.0071995226,
-0.008144583,
0.02050256,
-0.037277382,
-0.039508775,
-0.047200516,
0.0055817626,
-0.006096952,
-0.033260874,
-0.001803162,
0.004426689,
-0.011695122,
0.005053448,
-0.011951076,
-0.1643355,
0.017877392,
0.027931783,
-0.04055884,
0.00039910752,
0.0013257096,
0.0027941628,
-0.01573788,
-0.016184159,
0.020266294,
0.022917714,
-0.010369413,
-0.040480085,
-0.023784019,
0.018061154,
0.018008651,
-0.026172921,
0.022917714,
-0.016630437,
0.02589728,
0.015540993,
-0.0024053098,
0.032027047,
0.0048007756,
-0.012207029,
0.017457366,
0.010684432,
-0.007330781,
0.0016374483,
-0.003315915,
-0.004206831,
0.0058442797,
0.022537064,
0.016682941,
0.031397007,
-0.016394172,
-0.009306219,
-0.019150598,
-0.013650872,
0.029165613,
0.030898225,
0.007829563,
-0.003187938,
0.010356287,
-0.017496742,
0.0054078456,
0.00692388,
0.014084024,
0.0020492715,
-0.012804256,
0.012285785,
-0.0018244915,
-0.0035078803,
0.015160344,
0.021526376,
0.021880772,
0.0042658974,
0.02144762,
-0.019308109,
-0.02223517,
0.0060149156,
-0.007547357,
0.032657087,
0.015278476,
0.004446378,
-0.02255019,
-0.0036752347,
0.00692388,
-0.028246805,
-0.00050124293,
-0.018678067,
-0.010828816,
0.008754934,
-0.024925968,
0.017391736,
0.026002286,
0.015370357,
-0.0021838113,
0.0030337095,
0.005653955,
-0.0022002186,
-0.0058869384,
-0.04523164,
-0.022996468,
0.0068845022,
-0.0057064584,
0.035833538,
0.016394172,
0.006582608,
-0.003612887,
-0.0017391735,
-0.024059663,
0.012305474,
-0.018756824,
0.016827324,
-0.0004577636,
0.010946949,
-0.0054176897,
0.013795257,
-0.014438422,
0.01807428,
-0.015646,
-0.011754189,
-0.007947695,
0.027511757,
-0.02709173,
-0.04200268,
0.0046071694,
0.007967384,
-0.03066196,
0.014149654,
-0.0005824591,
0.0006058395,
0.026435439,
0.0011608163,
0.029611891,
-0.00018509483,
-0.019137472,
0.036279816,
-0.028404314,
0.06478914,
0.019203102,
-0.010894446,
0.025805399,
-0.0030140206,
-0.02551663,
-0.121912785,
-0.05208333,
0.01326366,
-0.0013773927,
-0.02942813,
0.00013166857,
0.014307164,
0.032972105,
-0.042527717,
0.017142344,
-0.024322178,
0.0013257096,
0.008676179,
-0.0062643066,
0.0058311536,
-0.01294864,
0.033260874,
-0.0050140703,
-0.019386863,
0.025385372,
0.011767314,
-0.009857505,
0.00096392876,
0.0008679461,
-0.003521006,
0.033917166,
-0.014215283,
0.017011087,
0.014438422,
-0.0050862622,
0.022786455,
-0.013480236,
0.042160194,
-0.0047253016,
-0.021683885,
-0.023180231,
-0.011222592,
-0.021670759,
0.03648983,
-0.020253168,
0.0028072887,
-0.00056236016,
0.020423805,
0.005696614,
-0.008689305,
-0.0075079794,
-0.025240988,
-0.0017260477,
0.01319803,
-0.023639634,
-0.035439763,
-0.017654253,
-0.008105205,
0.0009885397,
0.027039228,
-0.0010057674,
0.0106909955,
0.004682643,
0.011366976,
-0.021959528,
0.022274548,
0.0076786154,
-0.00346194,
0.015029085,
0.03037319,
0.008151146,
-0.026632326,
-0.039823793,
0.010841942,
-0.028561825,
-0.02639606,
0.023889026,
0.0046071694,
-0.016604185,
-0.0367786,
0.019071843,
-0.026186047,
-0.027984288,
0.01384776,
0.00018663301,
-0.018743698,
-0.021355739,
0.023390245,
0.0065629194,
-0.0047712424,
-0.014674688,
0.02041068,
0.018468054,
-0.0063430616,
0.0016308854,
-0.012108586,
0.021670759,
0.021316363,
-0.024965344,
-0.017641127,
0.025976034,
0.000026815678,
0.007580172,
0.030031918,
-0.012285785,
-0.016669815,
-0.006090389,
-0.048723113,
0.008728683,
-0.0065858895,
-0.0067335553,
0.0059853825,
-0.011301347,
0.021434493,
-0.03315587,
-0.00022765125,
-0.0069501316,
-0.013211156,
0.025306616,
-0.015357231,
-0.018809326,
-0.00912902,
-0.036201064,
0.036988612,
-0.023180231,
0.030950727,
0.03929876,
0.019242479,
0.016105404,
0.0018113657,
-0.010231591,
-0.013611495,
-0.003970566,
-0.018822452,
0.018336797,
0.005161736,
0.007855814,
-0.0022035001,
-0.06384408,
-0.0076851784,
0.014543429,
-0.018126782,
-0.011636056,
-0.0044660666,
0.0110388305,
0.03194829,
0.01288301,
-0.0250441,
-0.02182827,
-0.00020509123,
-0.034862228,
0.023009595,
0.004827027,
-0.01712922,
-0.01848118,
0.0105203595,
-0.008663054,
0.027380498,
0.014425296,
0.02214329,
-0.012732063,
-0.023350867,
-0.006582608,
-0.011859195,
-0.017365484,
-0.031554516,
0.002488987,
0.0037146122,
-0.004177298,
0.014346542,
-0.0061002336,
-0.0005726147,
-0.0147928195,
-0.028456818,
-0.009805001,
0.024295926,
-0.009234027,
-0.010060955,
0.016302291,
0.017628001,
-0.0014520459,
0.023994032,
-0.022340177,
-0.022038283,
0.0130864605,
-0.01596102,
0.01178044,
0.0030271464,
-0.0063004023,
-0.019688757,
0.010841942,
0.026763584,
0.012252971,
-0.024991596,
-0.012528613,
0.0059394417,
-0.0031961417,
-0.00096638984,
0.00887963,
0.013112713,
0.005398001,
0.01580351,
0.017207975,
-0.004154328,
-0.0055358224,
-0.011997016,
0.028246805,
0.003455377,
0.013408044,
-0.014215283,
-0.025464127,
0.0000018137755,
0.020856958,
-0.025503503,
-0.038721222,
-0.01526535,
-0.006208522,
0.0057655247,
0.013191468,
0.009778749,
-0.00022149853,
-0.015081588,
0.000035019326,
-0.028876845,
-0.004774524,
-0.017116094,
0.0060805446,
0.012049519,
0.01495033,
-0.020541938,
0.009732809,
0.010822254,
-0.0012937154,
0.027826777,
-0.010651618,
0.022970216,
-0.037828665,
0.015606622,
-0.0052536167,
-0.031895787,
-0.010028141,
-0.017929895,
-0.024059663,
-0.014556555,
0.0139396405,
-0.030084422,
0.06977696,
-0.00047335055,
0.0003269154,
-0.00294511,
-0.004439815,
0.019111222,
-0.010323472,
0.008498981,
-0.037802413,
-0.01040879,
0.007908317,
-0.03990255,
0.029165613,
-0.060063835,
-0.0077770595,
0.008085516,
-0.006139611,
0.022602694,
0.00469905,
-0.014031521,
0.006559638,
-0.014595932,
0.004282305,
-0.00039562097,
-0.042816486,
0.012764878,
0.04431283,
-0.009850942,
0.022786455,
-0.026159797,
-0.013289912,
-0.0075079794,
-0.025437875,
-0.0006821334,
0.025923532,
-0.0062150843,
-0.011156962,
-0.0059230346,
0.0160529,
0.019911896,
-0.006297121,
0.029953163,
-0.016932331,
0.017207975,
0.014805946,
-0.011065082,
-0.016315417,
-0.006759807,
-0.016013524
] |
Acute paraquat poisoning is often fatal. Many studies have investigated successful treatment modalities, but no standard treatment yet exists. The purpose of this study was to determine the predictors of survival after acute paraquat poisoning in 602 patients. The paraquat exposure was assessed based on the amount of ingested paraquat and a semiquantitative measure of the urine level of paraquat. Initial clinical parameters including vital signs, hemoglobin, white-blood-cell count, pH, PaCO2, PaO2, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase | [
0.021888943,
-0.0023433417,
0.021622654,
-0.02316713,
-0.029238515,
0.038318966,
-0.021715855,
-0.017228888,
-0.019186111,
0.019558916,
-0.009053821,
0.013474216,
-0.015671099,
0.023633135,
-0.010724783,
-0.007076626,
0.05054162,
0.0045069386,
-0.002721139,
-0.006890224,
0.0047166413,
0.029691206,
-0.012588805,
0.0140067935,
-0.0061579295,
0.0043804515,
0.016083846,
-0.03009064,
0.017002543,
-0.02134305,
-0.014339654,
-0.010511752,
-0.03222095,
-0.02146288,
-0.011437106,
0.014566,
0.0005958213,
0.0072031133,
-0.0017808066,
-0.022741066,
0.009666285,
0.012635405,
0.012682006,
-0.0036980864,
-0.0011733352,
-0.022674495,
-0.015085263,
-0.03842548,
-0.024538517,
0.025603672,
0.022448149,
-0.012022941,
-0.008661045,
0.0059781843,
0.012668692,
-0.013953535,
0.0074893734,
0.02479149,
-0.009213594,
-0.027507637,
-0.009632999,
0.000207206,
-0.01993172,
0.017561749,
-0.012415717,
0.015857501,
-0.0070965975,
0.0053856918,
-0.0074560875,
0.015697727,
0.015604526,
0.04100848,
0.0059116124,
-0.007229742,
0.030010752,
0.0007672447,
-0.043032277,
-0.0015877472,
-0.017162316,
0.015790928,
0.038505368,
-0.024525203,
-0.020198008,
0.012968266,
0.020277895,
-0.01897308,
-0.007802263,
0.028093472,
0.009053821,
-0.004427052,
0.010225492,
0.016190361,
0.023726337,
-0.00069484743,
-0.010798013,
0.017575063,
0.018041069,
0.027374493,
-0.005232576,
-0.04697335,
-0.020703958,
-0.008095181,
-0.026442481,
-0.007948722,
-0.031075908,
0.025603672,
0.0051926323,
-0.007010054,
0.022235118,
-0.0062012016,
-0.00836147,
0.04108837,
0.008035266,
-0.0097461715,
0.0034883837,
0.0030290356,
0.016057217,
0.0020321168,
-0.010438522,
-0.032780156,
0.028785823,
-0.0063210316,
0.028945597,
-0.025883276,
-0.0018041069,
0.0081684105,
-0.01837393,
-0.0230473,
0.01861359,
0.0053557344,
-0.013474216,
0.04106174,
0.027015002,
-0.004067562,
-0.011530307,
0.032540496,
-0.02958469,
-0.033073075,
-0.025603672,
-0.014379597,
0.0019289298,
0.008780874,
0.0021169963,
-0.016736254,
-0.0029508132,
0.009446597,
0.036375057,
0.017508492,
0.0023167129,
0.0058849836,
0.011257361,
-0.008867418,
0.02649574,
-0.020331154,
-0.02230169,
-0.01885325,
-0.013101411,
0.018799992,
-0.022727752,
-0.016949285,
-0.013034839,
-0.0057418533,
-0.019851834,
-0.0140067935,
0.0016226976,
0.021103391,
0.01597733,
-0.013740504,
-0.004154106,
-0.02886571,
-0.0033951828,
0.036401685,
-0.017521806,
0.019279312,
0.022448149,
0.012748579,
0.0024531859,
0.0183473,
-0.0054555926,
-0.0048231566,
-0.017881297,
0.020144751,
0.0059349127,
0.009925917,
-0.003827902,
-0.0009877651,
0.017841352,
-0.009013877,
-0.010198862,
0.0020620741,
0.006787037,
0.007289657,
-0.020024922,
-0.0063709607,
-0.65017086,
-0.019146169,
0.009286824,
0.011350562,
0.022008773,
0.01828073,
0.00812181,
-0.0020903675,
0.00019441165,
0.030676475,
0.0045169243,
0.0018224142,
0.0056586377,
-0.010584981,
-0.007382858,
-0.011024358,
-0.01525835,
-0.007895464,
0.01624362,
-0.000042075717,
-0.004017633,
-0.0011408812,
-0.030942764,
0.010045746,
0.0085611865,
0.028998856,
-0.0030706432,
-0.01732209,
0.00054381177,
0.019385828,
-0.00068444555,
0.018333986,
0.012429032,
0.02005155,
0.049316693,
-0.03099602,
-0.013753818,
-0.004643412,
0.014233138,
0.03581585,
-0.0056186947,
0.0011467063,
0.046067968,
-0.017188944,
-0.03206118,
0.0048298137,
0.007655804,
-0.0012715292,
-0.0015586219,
-0.0050528306,
0.016003959,
-0.006377618,
0.014752402,
0.017947868,
0.018027755,
0.012076199,
-0.0011259025,
-0.02961132,
-0.018081013,
-0.008201696,
-0.012715292,
0.011996312,
-0.007016711,
-0.024298856,
-0.040049843,
0.034937095,
-0.015378181,
0.0006461665,
0.0039444035,
0.0043105506,
0.023180444,
0.025936533,
0.0076957475,
-0.000012794347,
0.025071094,
0.01037195,
0.0035016984,
-0.0000064621854,
-0.0026529026,
0.013134697,
0.002594652,
-0.0070033967,
-0.018959766,
-0.001390527,
0.042126894,
-0.021689227,
-0.033312734,
0.015005376,
0.038239077,
-0.018786678,
0.019039651,
0.0049895872,
-0.008494614,
-0.0040475903,
-0.028918969,
0.017095743,
-0.021223221,
-0.018786678,
-0.00654072,
-0.0139269065,
-0.035176758,
-0.035336528,
0.006793694,
0.017162316,
0.01885325,
0.011037673,
-0.0026811957,
0.0025530444,
0.034031715,
-0.0071565127,
-0.0071964557,
-0.017788095,
0.015671099,
-0.016736254,
0.03030367,
-0.024445316,
0.01432634,
0.008760903,
-0.016177047,
-0.009772801,
0.028732566,
-0.011889797,
0.03861188,
-0.0022384906,
-0.011057644,
0.01738866,
0.0028908981,
-0.0026479096,
-0.010285406,
-0.033099703,
0.0049429866,
-0.0043238653,
0.025550414,
-0.0061978726,
0.0077223764,
-0.03339262,
0.03174163,
0.0016493265,
0.019479029,
0.00089872483,
-0.025590358,
-0.006800351,
-0.0012349145,
0.0069434815,
-0.015750986,
-0.02263455,
0.008021952,
0.0219422,
-0.010977757,
0.023033984,
0.0030240426,
-0.01233583,
-0.013187955,
0.03906457,
0.0061712437,
-0.0060847,
0.01284178,
-0.022820953,
-0.009353396,
-0.0050295303,
0.01678951,
-0.0064308755,
-0.00893399,
-0.0084812995,
-0.008135124,
-0.041594315,
0.021902258,
0.0008238311,
-0.0046533975,
-0.0194524,
-0.002736118,
-0.038958058,
-0.01780141,
0.001918944,
-0.0121694,
0.028839082,
-0.01603059,
-0.012981581,
-0.0057385247,
-0.0031039293,
0.015817557,
-0.013074782,
-0.0076691187,
0.024565145,
0.00014625082,
0.023113871,
0.0024714933,
0.051127456,
-0.01276855,
0.018120956,
0.008507929,
0.004340508,
-0.046201114,
0.018333986,
0.016163733,
0.0030057353,
-0.019878462,
-0.009426625,
0.0028992197,
0.03488384,
0.012429032,
-0.004796528,
0.018227471,
-0.015404809,
0.02419234,
0.0045169243,
-0.007948722,
-0.016509907,
0.029371658,
0.009546455,
-0.0030506717,
-0.0064475187,
-0.0061745727,
-0.028812453,
-0.031715002,
0.021356365,
-0.016203675,
-0.010644897,
-0.017015858,
-0.016922656,
0.016323507,
-0.016776197,
0.018054383,
0.013587388,
-0.0009852687,
-0.00450361,
0.0018590289,
0.025803389,
0.0003008232,
0.0076025464,
-0.004340508,
-0.025723502,
0.01777478,
-0.00058209075,
0.004693341,
-0.0007098262,
0.0065573626,
-0.005092774,
0.030543331,
0.003708072,
-0.033632282,
-0.0069701103,
-0.003368554,
-0.0035283272,
0.008521243,
-0.000627027,
0.014885547,
0.014818974,
-0.014179881,
0.0074827163,
-0.006640578,
0.018147584,
-0.009226908,
0.0044570095,
-0.015537954,
-0.03150197,
0.00083506515,
0.01624362,
0.024445316,
0.0007763984,
0.034963723,
-0.011763309,
0.019292627,
0.00048639323,
0.01597733,
-0.020464297,
-0.0072430563,
-0.02038441,
-0.0015270001,
-0.009812743,
-0.014672515,
-0.013061468,
0.009067135,
0.016975913,
-0.009939231,
0.015058634,
0.003478398,
0.0034218116,
0.009226908,
-0.00075684284,
-0.027960328,
-0.01236246,
0.025710188,
0.034164857,
-0.009952545,
-0.009799429,
-0.018906508,
-0.0030856219,
-0.009459911,
0.031075908,
0.0016784519,
0.012954952,
-0.016603108,
0.018933136,
0.011430449,
-0.015870815,
0.016256934,
-0.011863168,
0.0015611183,
-0.0056453235,
-0.0035449702,
-0.008188382,
-0.021662597,
0.013041496,
0.033818685,
0.00055754225,
-0.013993478,
-0.019439086,
0.0054256353,
0.004879743,
0.0019771946,
-0.010318693,
-0.010784698,
0.008727617,
-0.009386682,
0.010318693,
-0.0012174393,
0.021982145,
0.04721301,
-0.012315859,
-0.008474642,
-0.024112454,
0.005472236,
0.012136114,
0.033738796,
0.026309337,
-0.0041341344,
0.024325486,
-0.0071232263,
-0.0098992875,
0.0102920635,
-0.022075346,
0.016523223,
-0.009859344,
0.0050528306,
0.026029734,
0.020610757,
0.011217417,
0.02955806,
0.013940221,
-0.015111892,
-0.032034546,
-0.013267841,
-0.002366642,
0.0017158987,
-0.025097724,
0.03528327,
0.025403956,
0.008667702,
0.015364866,
0.008514586,
0.011417134,
0.03594899,
0.009752829,
-0.016762882,
-0.0035150128,
0.00043521583,
0.021662597,
-0.0085611865,
0.0058982978,
0.0123491455,
0.0070300256,
0.027401121,
-0.0007676608,
0.020118121,
0.0018573647,
0.0045269104,
0.010618268,
0.023180444,
-0.006477476,
-0.010165577,
0.0048298137,
-0.008001979,
-0.018413873,
0.027001688,
0.007875493,
-0.0043305224,
-0.028199987,
0.01453937,
-0.0034084972,
0.010758069,
0.0025663588,
-0.0005621191,
0.012721949,
-0.0007897128,
-0.025883276,
0.029052112,
-0.0073096287,
-0.01887988,
-0.011730024,
-0.026082993,
-0.006657221,
-0.009513169,
0.0129749235,
0.013560759,
-0.024045883,
0.0062611164,
-0.0067803795,
0.0206507,
0.002141961,
0.03219432,
-0.043697998,
-0.01015892,
0.018081013,
-0.020331154,
0.0070832833,
-0.010644897,
-0.00912705,
0.017668264,
0.025190925,
0.012455661,
-0.015231722,
-0.01564447,
0.020823788,
0.026216136,
-0.014486113,
-0.005625352,
0.024432002,
0.009286824,
-0.008980591,
0.002944156,
0.03368554,
-0.007016711,
-0.005991499,
0.0014462813,
-0.013940221,
-0.017588379,
-0.03440452,
0.017761465,
-0.028253246,
0.0096796,
0.0085279,
0.003691429,
-0.011337248,
0.023220386,
0.0063476604,
-0.0022168546,
-0.010917842,
0.030117268,
0.017588379,
-0.019079596,
0.021649282,
0.013227899,
-0.0015503004,
-0.0061313007,
0.0098260585,
0.03144871,
-0.0023416774,
-0.015071948,
0.009866002,
-0.0008879069,
-0.027294606,
-0.05698581,
-0.016869398,
-0.0025031152,
0.014512742,
0.012608777,
-0.014113309,
-0.010298721,
0.014366283,
-0.0101389475,
0.01887988,
-0.00018889864,
-0.026509054,
0.0017325418,
-0.009872659,
-0.010558353,
0.018813306,
0.035443045,
-0.017841352,
-0.008208354,
0.000108283864,
-0.008394755,
-0.0010368621,
-0.025563728,
-0.0064508473,
-0.01128399,
0.011310618,
-0.035869107,
-0.020597441,
0.010125633,
0.008940648,
0.028572792,
-0.014685829,
0.01552464,
-0.014366283,
0.009253537,
0.024112454,
-0.00740283,
0.020424355,
-0.026335966,
-0.015245036,
-0.00097278645,
0.020877045,
-0.009499854,
-0.014033422,
-0.006890224,
-0.010997729,
0.015910758,
0.03485721,
-0.016416708,
-0.010012461,
-0.008028609,
-0.029877609,
-0.02124985,
0.028333133,
-0.022354947,
0.012129457,
-0.017188944,
-0.0012240965,
0.016563166,
0.018160898,
-0.0070566544,
-0.011104245,
0.011370533,
-0.013261184,
-0.016336821,
-0.018866565,
0.015205093,
0.008973934,
-0.016123788,
-0.0040542474,
-0.010724783,
-0.017162316,
0.009120393,
-0.016496593,
0.008727617,
0.0022984056,
-0.011703394,
0.0072031133,
-0.018160898,
-0.021209907,
0.004050919,
-0.01732209,
-0.017947868,
0.01777478,
-0.0050628167,
-0.03126231,
0.0060713855,
-0.0015877472,
-0.0013422621,
0.009000563,
-0.03293993,
-0.030330298,
-0.00045726786,
-0.017069114,
0.024232285,
-0.011683423,
0.04460338,
0.015697727,
-0.025004523,
-0.011730024,
0.0034018399,
0.0095065115,
0.015577897,
0.009153679,
-0.001324787,
-0.014752402,
-0.021076761,
0.021622654,
0.023872795,
-0.032087807,
-0.033951826,
0.028359761,
-0.009672943,
0.006247802,
-0.01693597,
-0.015750986,
-0.034005087,
0.038958058,
-0.008820818,
-0.017215574,
0.0053856918,
-0.00077390193,
-0.005718553,
-0.00040359402,
-0.020624071,
0.017135687,
0.018866565,
-0.0068502803,
-0.005442278,
-0.011017701,
-0.021502825,
0.012808493,
-0.011543621,
0.022288376,
-0.02326033,
0.009166993,
-0.0070366827,
0.018693477,
0.0030107282,
0.02113002,
0.00080053083,
0.039996583,
0.00022384906,
0.013161326,
0.0048331423,
0.01188314,
-0.013274499,
-0.013833705,
-0.014526056,
-0.04984927,
0.0098260585,
0.0072430563,
0.022341633,
0.029185258,
-0.010698155,
-0.007223085,
-0.013594045,
-0.017468547,
-0.014233138,
-0.02661557,
-0.0023766279,
-0.030383557,
-0.013980164,
0.00031164117,
-0.02328696,
0.007076626,
0.0070033967,
-0.000120558114,
-0.030356929,
0.0037480155,
-0.018360615,
-0.006041428,
-0.005442278,
0.017149001,
-0.020717273,
0.005142703,
-0.035256643,
-0.01837393,
0.02050424,
0.0090338485,
-0.04175409,
-0.0329133,
-0.014885547,
0.02505778,
0.016057217,
-0.0055854083,
0.021076761,
0.008414728,
0.0043038935,
0.0018240786,
-0.015085263,
0.022754382,
-0.032966558,
0.021782428,
0.019066282,
-0.009479883,
0.00022738571,
-0.021556081,
0.002649574,
0.004486967,
-0.017761465,
-0.030969393,
-0.045775052,
0.018933136,
-0.019798575,
-0.03246061,
-0.008135124,
-0.015857501,
-0.021955514,
0.0024631717,
-0.00027253,
-0.0020737243,
0.0042339927,
-0.018586962,
-0.009107078,
-0.007775634,
0.0010227156,
-0.008075209,
-0.010145605,
-0.004250636,
-0.028812453,
-0.008541214,
-0.024392057,
0.0017475205,
0.018693477,
-0.022581294,
-0.022341633,
-0.011177474,
-0.041887235,
0.022927469,
-0.037839644,
0.0006528237,
0.018999709,
0.028918969,
-0.004257293,
0.028066844,
-0.017668264,
0.0136872465,
-0.026415853,
-0.02328696,
0.016962599,
-0.009386682,
0.038878173,
-0.025550414,
-0.012715292,
-0.014978747,
0.01128399,
-0.029637948,
-0.0012282573,
0.0046600546,
0.0071565127,
-0.023340218,
-0.015471382,
0.0046966695,
0.010738097,
0.0009153679,
-0.013554102,
-0.004786542,
-0.014419541,
0.014659201,
0.004290579,
-0.0010077368,
0.016057217,
0.051926322,
-0.006983425,
0.0037147293,
-0.02290084,
-0.041221514,
-0.008254954,
0.0019056295,
0.0051094173,
0.021569395,
0.003222095,
0.0043371795,
-0.005954884,
-0.015311608,
-0.031395454,
0.009293481,
-0.000121702324,
-0.00042023708,
0.02026458,
-0.00704334,
0.0069767674,
-0.017481862,
0.010684839,
-0.0040043183,
-0.0059515554,
-0.0038611882,
-0.018333986,
-0.008754246,
0.043857772,
0.02124985,
0.009060478,
-0.003564942,
0.000052607647,
-0.014486113,
0.012455661,
-0.03336599,
-0.01015892,
-0.04313879,
-0.021622654,
-0.010079033,
0.008634415,
0.026189508,
0.007835549,
-0.017428605,
-0.0090338485,
0.028599422,
0.17255516,
-0.02148951,
0.03198129,
0.006350989,
0.008807504,
0.000058198675,
0.004040933,
0.0035915708,
-0.011663451,
0.00086710305,
0.03246061,
-0.012129457,
-0.019545602,
0.004300565,
0.0075492887,
-0.014073365,
-0.023872795,
-0.0183473,
-0.01645665,
-0.0034417834,
-0.015657784,
0.0033186248,
0.039996583,
0.009593056,
0.028439648,
0.015458067,
0.00024943775,
-0.000676124,
0.022701124,
0.019718688,
0.0032886672,
-0.022741066,
0.01942577,
0.017242203,
0.008840789,
0.0015378181,
0.005442278,
-0.017455233,
-0.0023799564,
0.028093472,
0.012056227,
0.01876005,
-0.010618268,
-0.016110474,
-0.03483058,
0.01528498,
-0.0020071522,
-0.014898861,
-0.03270027,
-0.0036281855,
-0.03815919,
0.009000563,
0.0012598791,
-0.024858063,
0.0007988665,
0.0068070083,
0.021196593,
-0.030436814,
0.0010168905,
0.036162026,
0.009539798,
0.0057984395,
0.0010934486,
0.023553248,
-0.014885547,
0.027560895,
-0.004307222,
-0.014153252,
-0.01140382,
0.00064450223,
0.0017641636,
-0.0051759896,
-0.01396685,
0.037493467,
-0.013241213,
-0.023686392,
-0.01840056,
0.040182985,
0.01501869,
0.010358636,
0.0060580713,
-0.0031705014,
-0.027800554,
0.0007776466,
-0.037307065,
-0.014126623,
0.026788658,
0.0032037876,
-0.026309337,
0.0045135957,
0.0061512724,
-0.007376201,
-0.009153679,
0.0066838497,
0.008441356,
0.014992062,
0.0019389156,
0.017242203,
-0.0036215282,
-0.01897308,
-0.012255944,
0.060500823,
-0.0073628863,
0.007469402,
-0.028812453,
0.033312734,
-0.025696874,
0.039969955,
0.00028209973,
-0.0058616833,
0.0023766279,
0.007289657,
0.0031588513,
-0.005162675,
0.0014196524,
0.01717563,
0.01480566,
-0.0039277603,
0.013993478,
-0.011896454,
0.0025347369,
-0.039437376,
-0.011137531,
0.025523786,
-0.0005866676,
-0.02371302,
-0.033019815,
0.006863595,
0.0049196864,
-0.022594608,
-0.0054622497,
-0.009000563,
-0.007129884,
-0.0059815133,
-0.009752829,
0.027800554,
-0.016656367,
-0.009839373,
-0.008587815,
0.028306505,
-0.0012041249,
-0.008667702,
0.010285406,
-0.003674786,
0.0055454653,
0.003984347,
0.002005488,
-0.00074935344,
-0.0035016984,
0.0040143044,
-0.0109244995,
-0.013021524,
-0.019372514,
-0.010525066,
0.023659764,
-0.02338016,
-0.014912175,
-0.026695456,
0.023207072,
0.0014903854,
-0.0010127297,
0.009559769,
0.015138521,
-0.023513304,
-0.0024598432,
0.015444753,
-0.16776197,
0.028306505,
0.0073229433,
0.007862178,
0.01636345,
0.0064508473,
0.02745438,
0.011170817,
-0.01873342,
0.00029541418,
0.021409623,
0.0023949353,
-0.013494187,
-0.037120666,
-0.0003642748,
-0.0032337452,
0.01444617,
0.029318402,
0.036960892,
0.009519826,
0.0051526893,
0.010664868,
0.01597733,
-0.012635405,
0.02409914,
0.007283,
-0.027773926,
0.008840789,
0.0017242202,
-0.009772801,
-0.018520389,
-0.017162316,
0.018360615,
-0.013547445,
-0.0121893715,
-0.009080449,
0.008294897,
-0.008634415,
-0.009340081,
0.020943617,
0.0046034683,
0.021116706,
-0.0006615613,
-0.015804242,
-0.003974361,
0.018986395,
0.010525066,
0.019279312,
0.014938804,
0.0006831973,
0.0129749235,
-0.020437669,
0.01588413,
0.018746734,
0.007935408,
-0.0117965955,
-0.0011933069,
-0.0073096287,
0.0018024426,
0.010165577,
-0.0027311249,
-0.0230473,
0.015431439,
0.028998856,
-0.0009403325,
-0.016430022,
-0.030463444,
-0.003981018,
-0.0128218075,
-0.015098577,
-0.0029092056,
0.004433709,
0.014526056,
0.0015394824,
0.023699706,
0.008028609,
-0.0072963145,
0.01480566,
0.0025913233,
0.016802825,
-0.009380025,
0.015537954,
-0.027041633,
0.0009153679,
-0.0020271237,
0.01073144,
0.007416144,
0.026322652,
-0.018799992,
-0.029451545,
-0.008914019,
-0.020277895,
0.0071565127,
-0.030703103,
0.00860113,
0.024112454,
-0.003887817,
0.012868408,
0.021223221,
-0.02886571,
0.020184694,
-0.0067470935,
-0.03339262,
-0.010678182,
0.016749568,
-0.021103391,
0.0019289298,
-0.016323507,
0.0064375326,
0.0054489356,
0.01624362,
0.006307717,
-0.012881722,
0.02220849,
-0.026189508,
0.0010094012,
-0.014179881,
-0.02718809,
-0.022141917,
-0.019385828,
0.060447566,
0.00462344,
-0.013387672,
0.021742484,
-0.011144188,
-0.0025497156,
-0.124516666,
0.01552464,
0.022754382,
0.020424355,
0.002666217,
-0.011117559,
0.015564583,
0.015724355,
0.004067562,
0.032513868,
-0.009752829,
-0.029930865,
-0.009772801,
0.004903043,
0.040955223,
0.018041069,
0.041620947,
-0.026988374,
-0.0014903854,
0.02814673,
-0.016070532,
-0.007862178,
0.01049178,
-0.012941638,
-0.016682995,
-0.017548434,
-0.0008150935,
0.023992624,
0.0013688911,
0.022315005,
0.03365891,
0.0032736885,
0.023313588,
-0.010431865,
-0.0066838497,
0.021649282,
-0.016256934,
0.00012232644,
0.021382993,
-0.027614152,
0.003445112,
0.01597733,
0.015085263,
0.005275848,
0.054535955,
0.008208354,
-0.029291773,
0.009739514,
0.014166567,
-0.019479029,
-0.013141355,
0.0032853386,
0.0071831415,
-0.0034817266,
0.006640578,
-0.009120393,
0.004447024,
0.026402539,
-0.02220849,
0.02568356,
-0.0053424197,
0.016057217,
-0.009985832,
-0.0010584982,
0.016150419,
-0.020943617,
-0.031928033,
-0.030703103,
0.023553248,
-0.022767697,
-0.023073928,
0.005458921,
-0.006770394,
0.0025597014,
-0.01609716,
-0.003967704,
-0.003538313,
0.010198862,
0.00046101256,
-0.0022767696,
0.00034222277,
-0.010844613,
-0.015391495,
-0.010631582,
0.0024115783,
0.0062910737,
0.025164295,
-0.009939231,
-0.0022368263,
-0.01720226,
-0.008221668,
0.026682142,
-0.0050694738,
-0.02160934,
-0.007649147,
0.022394892,
0.0025347369,
-0.041913863,
0.016922656,
0.03914446,
-0.004956301,
-0.022221804,
-0.046946723,
0.013234556,
0.009812743,
-0.008987248,
-0.023579877,
0.007509345,
0.010957786,
0.017481862,
0.007955379,
-0.0045968113,
-0.01744192,
-0.0010609946,
-0.029424917,
0.0013971842,
-0.031129166,
-0.0003854947,
0.007948722,
0.011011044,
0.009080449,
-0.0011899782,
0.008614444,
-0.007509345,
0.00917365,
0.015737671,
-0.008674359,
-0.0032087804,
-0.009686257,
-0.003734701,
-0.007802263,
-0.014286396,
0.009632999,
-0.0064109038,
0.013700561,
-0.012329173,
-0.011070958,
-0.027321234,
0.008594472,
0.020730587,
-0.0050395164,
0.018307358,
-0.009719543,
-0.0085279,
0.0010327015,
-0.030623216,
0.0074494304,
0.027068261,
-0.00896062,
0.020757215,
0.010178891,
-0.018320672,
0.024951264,
0.023952682,
-0.008787531,
-0.012555519,
-0.025137667,
-0.0016177048,
-0.01228923,
0.0037979446,
0.000604975,
-0.024072511,
0.018480446,
-0.027534267,
0.0036115425,
0.00019659605,
0.009226908,
0.0020404384,
-0.011576908,
-0.016177047,
0.010997729,
-0.02139631,
-0.01305481,
-0.0069235098,
0.007822235,
-0.009153679,
0.011603536,
0.01753512,
0.00018681826,
0.020424355,
-0.008341498,
0.009466568,
-0.0060647284,
0.02146288,
-0.048970517,
0.011789938,
0.036135394,
0.00091952865,
-0.02457846,
0.017228888,
-0.016043903,
0.014246453,
-0.020703958,
0.0023916066,
-0.014619257,
-0.015937388,
-0.002855948,
0.010052403,
0.008607787,
-0.00941331,
0.017575063,
0.016296877,
0.0050195446,
-0.0074627446,
-0.0042872503,
-0.032247577,
-0.011623508,
-0.017721523,
-0.03509687,
-0.043484967,
-0.032780156,
-0.0012024605,
0.009180307,
0.013900277,
-0.0013614018,
0.013460901,
-0.009233566,
0.012395745,
0.004247307,
0.014153252,
-0.0066006347,
0.03413823,
0.010817984,
0.019106224,
0.020011606,
-0.0046034683,
0.02124985,
-0.0014729102,
0.014752402,
-0.015724355,
0.04196712,
-0.011783281,
0.006983425,
-0.026935115,
-0.041221514,
-0.008075209,
0.018320672,
-0.036960892,
0.03435126,
0.014792345,
0.014299711,
0.069181845,
0.013207926,
-0.01204957,
-0.008854104,
0.016177047,
0.009453254,
0.010871242,
0.013474216,
0.021982145,
-0.048091765,
0.02409914,
-0.0150320055,
0.025097724,
-0.03698752,
-0.014645887,
-0.0010476802,
0.0013106404,
0.010365293,
-0.001117581,
-0.026642198,
0.04052916,
0.014352969,
-0.0004938826,
0.028546164,
-0.023433419,
-0.0051160743,
0.016962599,
-0.0023866137,
-0.0029191915,
-0.030277042,
0.0063975896,
0.010798013,
-0.012828465,
-0.029637948,
0.017228888,
-0.0030406858,
-0.015138521,
-0.02589659,
0.0125821475,
-0.013780448,
-0.002251805,
0.024005938,
-0.00474327,
-0.0068036797,
-0.036854375,
-0.014273082,
-0.021382993,
-0.0140067935,
0.011011044
] |
Adult neurogenesis has been shown to be regulated by a multitude of extracellular cues, including hormones, growth factors, and neurotransmitters. The cholinergic system of the basal forebrain is one of the key transmitter systems for learning and memory. Because adult neurogenesis has been implicated in cognitive performance, the present work aims at defining the role of cholinergic input for adult neurogenesis by using an immunotoxic lesion approach. The immunotoxin 192IgG-saporin was infused into the lateral ventricle of adult rats to selectively lesion cholinergic neurons of the cholinergic basal forebrain (CBF), which | [
-0.011075043,
0.0065476336,
0.016346052,
-0.011022398,
-0.036219273,
0.0107131135,
0.004392508,
-0.01718836,
-0.021386743,
-0.006419313,
0.003987805,
0.011680452,
-0.023018716,
0.016898816,
-0.0022653497,
-0.011456714,
0.033639703,
0.0056592613,
-0.008245412,
0.007857161,
-0.015990702,
0.019846898,
0.022465952,
-0.016346052,
0.01312817,
0.0018688723,
-0.00075717294,
-0.04848539,
-0.0061133183,
-0.02074185,
-0.0063535077,
0.0058961604,
-0.01153568,
-0.015674837,
-0.00039668297,
-0.009732613,
-0.0030369174,
-0.018070152,
0.007620261,
0.01803067,
0.018241247,
0.016214442,
-0.0062515098,
-0.00638312,
0.005475006,
-0.0062383483,
-0.025585126,
-0.01938626,
0.0005544102,
0.031560253,
0.016030187,
0.016833013,
-0.008738953,
-0.005349976,
-0.007271493,
-0.019846898,
0.01300314,
0.016661918,
0.03766699,
-0.03274475,
-0.01581961,
-0.0007115205,
-0.014148153,
0.026453756,
-0.0030434981,
0.008416506,
0.006284412,
0.005547392,
-0.004491216,
-0.0019313875,
0.0042839292,
0.0049913367,
-0.022689689,
-0.0024479595,
0.03298165,
0.0025367967,
-0.026124729,
-0.0049748854,
0.0007329072,
0.011891029,
0.01166071,
-0.038377687,
-0.008159865,
0.031797152,
0.017872736,
0.018017508,
0.0065344726,
0.015095751,
0.0045866338,
0.01189761,
0.0025055392,
0.0016796819,
0.03129703,
0.020452308,
0.018135957,
0.022242213,
-0.009390425,
0.014793046,
0.0022867364,
-0.0032425593,
-0.007626842,
-0.00096487114,
-0.016188119,
-0.025545642,
-0.014569308,
-0.0036028437,
0.013200556,
-0.0035863924,
0.037798602,
-0.009765516,
-0.007949288,
0.030112535,
-0.0019593546,
-0.04074668,
0.017951703,
0.008324378,
0.019425744,
0.015977543,
0.000834083,
-0.018965106,
0.027164454,
0.0029908537,
0.016911978,
-0.017069912,
0.005619778,
0.015740642,
-0.0021288034,
-0.0063995714,
-0.02208428,
-0.0011014172,
-0.03706158,
-0.008548116,
-0.0019461936,
0.009350942,
-0.030507367,
0.0075741974,
-0.004122706,
-0.003583102,
-0.006817436,
-0.038456656,
-0.0058468063,
0.03253417,
-0.02882275,
0.014740402,
-0.003852904,
0.04869597,
0.01730681,
0.034139823,
0.026927555,
0.0028279854,
0.00821909,
-0.008916627,
0.00079542235,
-0.014121831,
0.0137664825,
0.03216566,
0.006314025,
0.047142964,
0.0047544376,
-0.01963632,
0.017741127,
-0.03029679,
0.001189432,
-0.008692889,
0.028164696,
0.019188844,
0.00007197462,
-0.0087455325,
0.03127071,
-0.030744266,
0.004714954,
0.032349918,
-0.016095992,
0.018438663,
-0.020004831,
0.004596505,
0.016833013,
0.027769864,
-0.0055704243,
-0.013700677,
-0.02724342,
0.010930271,
0.013805965,
-0.01630657,
-0.007251751,
0.0027062455,
0.009910287,
-0.032507848,
-0.0053433958,
-0.024018958,
-0.021794736,
0.0010833208,
-0.0146745965,
-0.054065686,
-0.64941996,
-0.009607583,
0.019320454,
-0.010778919,
0.02345303,
0.024821782,
-0.0010512407,
-0.017991187,
-0.025861507,
0.029243903,
0.0009089366,
0.02417689,
0.009726033,
-0.001816228,
-0.014042865,
-0.029954601,
-0.00093443616,
-0.017017268,
0.053697176,
0.008146704,
0.0008982432,
0.0030467883,
-0.0074491673,
0.031718187,
0.0099563515,
0.014582468,
0.017096233,
-0.020083796,
-0.01754371,
0.027059166,
-0.009146946,
0.025124488,
0.004807082,
-0.001147481,
0.04661652,
-0.0035304578,
-0.021531515,
0.026058923,
-0.015411616,
0.032507848,
-0.0010265637,
-0.006896402,
-0.0010997722,
-0.009364103,
-0.030823233,
0.018399179,
-0.00059800624,
-0.0058500967,
0.010601244,
-0.021334099,
0.013569066,
-0.006935885,
-0.004392508,
0.0078374185,
0.008758694,
0.012772821,
0.006981949,
-0.0045339894,
-0.00003645,
0.008903465,
0.0018836785,
0.015437938,
-0.04232601,
0.009258815,
-0.01755687,
0.017741127,
-0.036745716,
-0.0033527834,
0.002857598,
-0.021281455,
0.002342671,
0.006810855,
-0.015845932,
-0.031876117,
0.018688723,
-0.0074754893,
0.004527409,
0.0058468063,
-0.022373823,
0.0120752845,
-0.005422362,
-0.016793529,
-0.0117989015,
0.009239073,
0.015793288,
-0.012055542,
-0.004329993,
0.005573714,
-0.004023998,
-0.0077584526,
0.011917352,
0.013779643,
-0.018214924,
-0.023650447,
-0.007633422,
-0.00039565476,
0.020399664,
0.008534956,
0.020926105,
-0.020202247,
-0.0054157814,
0.01067363,
-0.0050472715,
0.009837902,
0.016003864,
0.02084714,
-0.038956776,
0.025848348,
0.052354746,
-0.018859817,
-0.0020136442,
0.016359214,
-0.020004831,
0.007409684,
-0.005596746,
-0.019202005,
0.005498038,
-0.0018063572,
0.0026766332,
-0.019004589,
0.020228568,
-0.009377264,
-0.018596595,
-0.007988771,
0.01926781,
0.002699665,
-0.004063481,
-0.0009739194,
-0.024084764,
0.004366186,
-0.014753562,
0.0039450317,
0.02012328,
-0.018241247,
0.027559286,
0.022992395,
0.014806206,
-0.015345811,
0.021544676,
-0.035508573,
-0.02625634,
-0.00083572813,
0.008067737,
0.009614164,
-0.017951703,
-0.0094496505,
-0.0040042563,
0.005373008,
-0.023137165,
0.0030352725,
0.012470117,
-0.00920617,
-0.029428158,
0.019952185,
0.013351908,
-0.008153285,
-0.022531757,
-0.01288469,
0.0154511,
-0.0011565293,
-0.0022554789,
0.038509298,
-0.004514248,
0.02379522,
-0.031718187,
-0.00969313,
0.0081138015,
0.027532965,
0.017254166,
-0.04182589,
-0.0052282363,
-0.015872253,
-0.029612413,
0.0068898215,
0.021307778,
0.0059553855,
-0.008232251,
0.0063995714,
0.0045076674,
-0.017372616,
-0.021992153,
0.0061067375,
-0.003533748,
-0.0015283296,
0.031349674,
0.01262805,
0.026677495,
0.0020778044,
0.019781092,
0.020636562,
0.0099563515,
0.038430333,
-0.01079866,
0.004093094,
-0.005129528,
-0.05643468,
0.020057475,
0.004195092,
0.019254649,
0.03524535,
0.028138373,
-0.016214442,
0.024677012,
0.00036604234,
0.017109394,
-0.0153063275,
-0.010377506,
-0.0041325768,
-0.02270285,
0.004267478,
0.008738953,
0.020439146,
0.005853387,
-0.011976576,
0.0064094425,
0.008232251,
-0.008140123,
0.0022637045,
-0.00723859,
-0.026269501,
0.0026684075,
-0.01165413,
0.0038956776,
-0.0016056509,
-0.003471233,
0.027059166,
0.01853079,
0.00080734957,
-0.008094059,
-0.017004106,
0.0019396131,
0.008080899,
0.000041256877,
0.017951703,
0.0068042744,
0.0108644655,
-0.009561519,
-0.006587117,
0.02774354,
0.010476214,
0.0121016065,
0.011232976,
0.0018491307,
0.0020662884,
0.014174475,
0.0022752204,
0.011476455,
0.007126721,
-0.01018667,
0.010647308,
-0.014385052,
-0.00576455,
-0.020452308,
-0.0043464443,
-0.010351184,
0.013095267,
0.0068766605,
0.0056724222,
0.018017508,
0.031428643,
0.029085971,
-0.001191077,
-0.014134992,
-0.01692514,
-0.0026651172,
0.006856919,
0.006330476,
-0.003813421,
-0.015622193,
-0.0039285803,
-0.019978508,
0.00257628,
-0.034060854,
-0.0066266,
0.02392683,
-0.0011869642,
0.007422845,
-0.0038956776,
0.020583918,
-0.0016295053,
-0.012601727,
-0.016793529,
0.011022398,
0.0125030195,
0.011864707,
-0.005261139,
-0.021886865,
-0.026164213,
0.0003092852,
0.003889097,
-0.016030187,
0.010377506,
-0.015516905,
-0.013555905,
-0.018688723,
-0.018938784,
0.017293649,
0.00087932416,
-0.002747374,
-0.03950954,
-0.005215075,
0.011805482,
-0.0228213,
-0.006573956,
0.014714079,
0.01226612,
-0.02724342,
-0.0054782964,
-0.013404553,
0.0094759725,
0.012976818,
0.0091995895,
-0.0016739239,
-0.027954118,
0.007922966,
0.027427675,
-0.011496197,
0.004626117,
0.016951462,
0.004149028,
-0.022215892,
-0.028243663,
-0.014556146,
-0.023716252,
0.033823956,
0.002846082,
-0.016648756,
0.016569791,
0.0057612597,
-0.023913668,
-0.014529824,
0.006935885,
0.022150086,
-0.030849554,
0.0042773485,
0.0074557476,
-0.011246136,
-0.0007135769,
0.007350459,
0.0061133183,
-0.0026536013,
-0.009127204,
-0.00021283922,
-0.005616488,
0.018017508,
0.021992153,
-0.011265879,
0.043378897,
0.019702125,
0.001827744,
0.007067496,
0.028112052,
0.012825466,
-0.028875394,
-0.0017866156,
0.02330826,
-0.008962691,
0.013503261,
-0.0046952125,
-0.0071991067,
0.0021748673,
0.023387225,
0.010930271,
0.017069912,
0.036035016,
-0.005975127,
0.017043589,
-0.0024150568,
0.0010010641,
-0.0017685192,
-0.0012815595,
0.0021699318,
-0.014240281,
-0.017438421,
0.008455989,
0.0029414997,
0.0011680452,
0.006600278,
0.011614647,
-0.021057716,
0.015477422,
-0.0031010779,
0.010074801,
0.0140691865,
-0.009607583,
-0.03885149,
0.016214442,
-0.01891246,
0.0018211635,
-0.010206412,
-0.009897127,
0.0029135325,
0.0023870897,
0.0019149361,
0.0042839292,
-0.02869114,
-0.034929488,
0.00007063794,
0.031375997,
0.016517146,
0.029507125,
-0.018254409,
0.007593939,
0.025690414,
0.011094784,
-0.030823233,
-0.005425652,
-0.008699469,
0.0099563515,
0.03974644,
0.01595122,
-0.033771314,
-0.006402862,
-0.014872012,
0.033297513,
-0.008047996,
0.029744023,
-0.007264912,
-0.007896644,
-0.008949529,
0.02724342,
0.029375514,
0.03266578,
-0.00055523275,
-0.007718969,
-0.02491391,
-0.007949288,
-0.021149844,
-0.016859334,
-0.0018540662,
-0.006544343,
0.013805965,
-0.009416748,
-0.005728357,
0.021084039,
-0.015806448,
0.015898576,
0.013569066,
-0.009923449,
0.0019149361,
0.003852904,
0.017254166,
0.004761018,
0.0055276505,
0.022057958,
-0.015872253,
0.030138856,
0.0019297423,
-0.028559528,
-0.004596505,
0.027401354,
0.005261139,
-0.014121831,
0.019149361,
-0.0029036617,
0.038114466,
0.006531182,
-0.039825406,
-0.023374066,
-0.018346535,
-0.021492032,
-0.0028411467,
-0.006797694,
-0.008061157,
-0.009916868,
-0.00785058,
0.0065410533,
-0.015135233,
0.032113016,
-0.030981164,
-0.0076729055,
0.021202488,
0.006955627,
-0.0033560735,
-0.026124729,
0.003336332,
-0.010574922,
-0.0033692345,
-0.018096475,
-0.030507367,
0.008173026,
-0.0117725795,
0.03561386,
0.005619778,
0.042010143,
-0.0071333013,
-0.02528242,
0.025848348,
0.012450375,
0.0143718915,
-0.00576455,
0.0304284,
-0.037982855,
0.02528242,
-0.019149361,
0.0044616037,
0.013726999,
-0.017162038,
0.02097875,
0.019702125,
0.0023360904,
-0.025321905,
-0.009528616,
-0.01705675,
-0.026203696,
0.02551932,
-0.0003831106,
0.004257607,
-0.01472724,
0.0014921366,
0.031323355,
0.0016105863,
0.023216132,
-0.017675322,
0.023782058,
-0.04648491,
0.008752113,
0.011785741,
-0.0057250666,
0.00044829905,
-0.02686175,
0.0011918996,
-0.009153526,
0.005139399,
0.0066200197,
0.0027786314,
0.005692164,
-0.005057142,
-0.0114698745,
0.011213234,
-0.0129833985,
0.0014847335,
-0.04453707,
-0.00944307,
-0.02036018,
-0.014911495,
-0.008153285,
-0.026085246,
0.00687008,
0.019096717,
-0.018096475,
0.027927795,
-0.014187637,
0.0065542143,
0.018214924,
-0.01472724,
0.024269018,
-0.025848348,
0.019794254,
0.013404553,
0.014213959,
-0.0063600885,
-0.011858126,
-0.0043628956,
0.015029945,
0.0373248,
0.031507608,
-0.013325586,
-0.020004831,
0.0099563515,
0.024834944,
-0.0031175292,
-0.022558078,
0.02345303,
0.020544434,
-0.004158899,
-0.01030512,
-0.02037334,
-0.027532965,
0.005001208,
-0.011996318,
-0.0051492695,
0.009166687,
-0.00613964,
-0.014516663,
0.016267085,
-0.0021978992,
0.005948805,
-0.004770889,
0.0152142,
-0.010732855,
-0.0007012384,
-0.010634147,
0.020755012,
0.00042526715,
0.04256291,
-0.0032968486,
0.0016928429,
0.00041724712,
0.019583676,
0.011226395,
-0.0007440119,
0.007830839,
0.037851244,
-0.019609999,
0.0031093035,
0.0076597445,
-0.0020103538,
0.00023504853,
-0.013503261,
0.0018178732,
-0.0054092007,
-0.016398696,
-0.021505192,
0.028612172,
0.011456714,
-0.016490825,
0.002405186,
-0.019044071,
0.002870759,
-0.032455206,
-0.0056954543,
0.008969271,
-0.040457137,
0.0122529585,
0.0046326974,
0.023031877,
0.020057475,
-0.017872736,
-0.0068832412,
0.0036489074,
0.01459563,
-0.021320937,
0.026414273,
0.010193251,
0.01876769,
-0.021742092,
0.0020268052,
0.0036686491,
0.002734213,
-0.0005922483,
-0.031691864,
-0.04245762,
0.009699711,
-0.0062416387,
0.023466192,
0.023584642,
0.004859726,
0.025874669,
-0.015016784,
0.012187153,
0.021926347,
-0.007613681,
0.0008439538,
-0.020662883,
-0.0070082713,
0.0014065896,
-0.023137165,
-0.019346777,
0.0048926286,
0.004099674,
0.018754529,
-0.013174234,
0.0056987447,
-0.013898092,
0.00020769818,
-0.0027704057,
-0.014621952,
-0.009581261,
-0.019596837,
-0.029428158,
0.01988638,
-0.016517146,
-0.020399664,
-0.020215407,
0.021202488,
0.014885173,
0.002688149,
-0.013832288,
0.018701885,
-0.0037870987,
-0.027322387,
-0.059330117,
0.0071464623,
-0.00026116503,
0.03385028,
0.013417713,
0.0050374004,
-0.017162038,
-0.02858585,
-0.0576455,
-0.008548116,
-0.0040832227,
0.008061157,
0.00748207,
0.022913428,
-0.022900267,
-0.018307053,
0.020570757,
0.015556388,
-0.00077280175,
-0.0018639369,
0.0038594846,
-0.0035501993,
0.0019494839,
0.02097875,
-0.009397006,
-0.017978026,
0.02821734,
-0.019715287,
-0.022637045,
0.012904432,
-0.030138856,
0.013977059,
-0.015319489,
0.02761193,
0.010403828,
-0.008350701,
0.0131873945,
-0.017951703,
-0.0018260989,
-0.0034975552,
-0.01951787,
-0.015043106,
-0.010693371,
-0.004721535,
0.0065969876,
0.004757728,
-0.025585126,
-0.011680452,
0.037588023,
0.0002969467,
0.021860542,
0.021610482,
0.0026453757,
0.0007793823,
-0.00380355,
-0.0054289424,
-0.022136925,
0.0073570395,
-0.021926347,
-0.000119991964,
-0.006123189,
-0.009758935,
0.01202922,
0.0049748854,
0.024255857,
-0.040562425,
0.021623643,
-0.011719936,
0.0014707498,
-0.021636803,
0.027059166,
0.003704842,
-0.016582951,
-0.0027013102,
-0.007580778,
-0.009719452,
-0.021426227,
-0.018043831,
-0.012989978,
-0.028875394,
0.005001208,
0.020689206,
-0.014200797,
-0.008179607,
-0.019149361,
0.017872736,
-0.01876769,
0.0055144895,
0.17014635,
-0.014161314,
-0.0037739377,
0.002258769,
0.0061988654,
0.0210972,
0.028322628,
0.0042378656,
0.006856919,
-0.01030512,
-0.0015908447,
0.019228328,
-0.021873703,
0.0046919226,
0.003813421,
-0.017385777,
-0.0108381435,
-0.024584884,
-0.00039174754,
-0.0085415365,
0.027822508,
-0.0068634995,
0.014977301,
-0.02257124,
0.030744266,
-0.001048773,
-0.021900024,
0.0033955567,
0.003203076,
0.019688964,
-0.026374789,
0.012463536,
0.009673389,
0.015148395,
-0.012693855,
-0.0056493906,
-0.0031701734,
0.0070740767,
-0.001466637,
-0.0022472532,
0.037008937,
0.0071201404,
-0.0024150568,
-0.000010918292,
0.0009377264,
0.026124729,
0.0051459796,
-0.013226878,
-0.0026174083,
0.01091053,
-0.037377447,
-0.001141723,
0.007909805,
0.020689206,
0.021202488,
0.008791597,
0.022650206,
0.0077979355,
0.011331684,
0.025321905,
-0.02688807,
0.004310251,
-0.030586332,
0.03127071,
0.0072583314,
0.027322387,
-0.014082348,
-0.019044071,
0.016898816,
-0.009311459,
0.015148395,
0.018504469,
-0.02576938,
0.009067979,
-0.013240039,
-0.018043831,
0.0208603,
0.016977783,
0.018135957,
0.02405844,
-0.013068945,
0.022163246,
-0.022189569,
-0.0018195183,
-0.015648516,
-0.037351124,
0.019860059,
-0.00343504,
-0.027190777,
-0.020057475,
0.004122706,
-0.006369959,
-0.01680669,
-0.004119416,
-0.0009040012,
-0.017122556,
0.012325345,
0.00931804,
-0.009107462,
0.0014781529,
-0.03545593,
0.082019806,
0.02882275,
0.026335306,
-0.0067779524,
-0.00052603165,
-0.0009508875,
0.027980441,
-0.01976793,
-0.006784533,
-0.0015266844,
-0.016490825,
0.009035076,
-0.022465952,
-0.011081623,
0.0048630163,
-0.0011269168,
-0.009976093,
0.038956776,
-0.0037344543,
-0.010285378,
-0.008416506,
0.0057974528,
0.0074425866,
-0.008015093,
-0.013542743,
-0.0348242,
-0.0105486,
-0.008627083,
-0.034455687,
0.0031027228,
-0.008824499,
-0.003471233,
-0.010903949,
0.0023854445,
-0.016280247,
0.005879709,
0.011568583,
-0.010206412,
0.039062064,
-0.005481587,
-0.005201914,
0.020728689,
-0.017859576,
0.014937817,
-0.008903465,
-0.0015480712,
0.006040932,
-0.010206412,
-0.018728206,
-0.013503261,
-0.01642502,
0.014937817,
0.0011877868,
0.0022785107,
-0.035640184,
-0.0053401054,
-0.044300172,
-0.015503744,
-0.015227362,
-0.024084764,
-0.01006164,
0.0066397614,
-0.009278556,
-0.014937817,
-0.0085415365,
-0.16477662,
0.0009821451,
0.012035801,
-0.02834895,
0.0072056875,
0.002112352,
0.010331442,
-0.006452216,
0.00048284687,
0.0049354024,
0.006231768,
-0.01718836,
-0.032244626,
-0.024005797,
0.01092369,
0.016517146,
0.016227603,
0.03290268,
0.0011886094,
0.026953876,
0.009522036,
-0.021084039,
0.019096717,
-0.0031767539,
0.020649724,
0.019320454,
-0.0036719393,
-0.012608307,
-0.0015850867,
-0.019478388,
-0.0070082713,
-0.027375031,
0.034034535,
-0.0020399662,
0.011009238,
0.008581019,
0.012200315,
-0.019109877,
-0.012160831,
0.023387225,
0.016148636,
0.040799327,
-0.00748207,
0.009403586,
-0.008133543,
0.011923932,
0.0033017842,
-0.02012328,
0.00028049535,
-0.019846898,
0.034429368,
0.0063535077,
-0.010824982,
0.017859576,
0.016188119,
0.013661194,
0.0030599495,
0.008975851,
0.012654372,
0.014714079,
0.00040614247,
-0.008054577,
0.016740885,
0.022834461,
0.008416506,
-0.034087177,
-0.0070938184,
0.0017570033,
-0.021307778,
0.014490341,
-0.021742092,
-0.026585367,
0.011956834,
-0.03005989,
0.01667508,
0.007396523,
0.0018688723,
0.005093335,
-0.002294962,
0.026216857,
-0.008600761,
0.00052520906,
-0.04490558,
-0.012581985,
-0.0348242,
-0.00006719345,
0.02270285,
0.009923449,
0.015398455,
0.00490908,
-0.010699952,
-0.022031635,
0.016569791,
-0.0016221022,
0.016174959,
0.010726274,
-0.0029530157,
-0.008001932,
0.024874428,
0.006955627,
0.021018233,
0.007646583,
-0.020544434,
-0.015424777,
0.010035318,
-0.007159624,
-0.033929244,
0.01324662,
0.026980199,
0.016372375,
-0.0030402078,
0.0033034293,
0.00039462655,
0.01337165,
-0.015135233,
0.006320605,
-0.005113077,
-0.005373008,
0.020662883,
-0.024519078,
0.07580778,
-0.004181931,
0.00564281,
0.020175925,
-0.014872012,
-0.029138615,
-0.14056025,
-0.0389831,
-0.0032211726,
0.024203213,
-0.002967822,
0.00020687561,
0.004208253,
0.04598479,
-0.014016543,
0.025361387,
-0.025848348,
-0.0074623283,
0.0020136442,
-0.012068704,
0.008929788,
0.0026272791,
0.0013975414,
0.0025302162,
-0.008363862,
0.019531032,
0.0024841526,
-0.011022398,
0.0010479505,
-0.00007804105,
-0.008271734,
0.02442695,
-0.016569791,
0.020531273,
0.01092369,
0.014621952,
0.02528242,
-0.027980441,
0.02969138,
0.0013029462,
-0.0004003845,
-0.004797211,
0.0029595962,
-0.028033085,
0.043484185,
-0.00810064,
-0.014858851,
0.0010438376,
0.018859817,
0.006916144,
0.0013745095,
-0.007890063,
-0.004181931,
0.0033955567,
0.0019461936,
-0.025308743,
-0.04380005,
-0.024492756,
-0.0186624,
-0.014227119,
0.019965347,
0.02087346,
0.0038594846,
0.017162038,
-0.01963632,
-0.007646583,
0.03140232,
0.017162038,
-0.04453707,
-0.01938626,
0.021794736,
-0.004714954,
-0.0380355,
-0.04332625,
0.016609274,
-0.020004831,
-0.012568824,
0.0021139972,
-0.002355832,
-0.015016784,
-0.039720118,
0.011226395,
0.01546426,
0.001926452,
0.0014929592,
0.011075043,
-0.013141331,
-0.011476455,
0.032507848,
-0.0024315082,
-0.00041046095,
-0.0043859277,
0.006613439,
-0.008245412,
-0.017925382,
0.0048630163,
-0.02380838,
0.01276624,
-0.022939749,
-0.009962932,
0.0007653986,
-0.0000032131525,
-0.00054536195,
-0.009772097,
0.03656146,
0.017227843,
0.00016502751,
-0.02528242,
-0.04061507,
-0.002281801,
0.008528375,
-0.0038923873,
0.0052973316,
0.012305603,
0.022597563,
-0.021123521,
-0.019057233,
-0.0028608881,
-0.01362171,
0.0113185225,
0.002992499,
-0.00084806664,
-0.019057233,
-0.015069428,
0.030191502,
-0.009535197,
-0.003045143,
0.013240039,
0.020926105,
-0.012345086,
0.015990702,
0.023045039,
-0.031849798,
-0.012259539,
0.0017092943,
0.012674113,
0.0051492695,
-0.0051591406,
0.0055704243,
-0.043984305,
0.002380509,
0.009239073,
0.012206895,
-0.0066562127,
0.0072254287,
0.022189569,
0.012509599,
0.044695,
-0.031612895,
-0.04072036,
0.006392991,
-0.029665058,
-0.002158416,
-0.009679969,
-0.040430814,
0.006856919,
0.0048531457,
-0.026322145,
0.0034547816,
0.0075412947,
0.016161798,
-0.016530307,
-0.015503744,
0.029507125,
-0.019728448,
0.0018886139,
-0.0045932145,
-0.016267085,
-0.0024265728,
0.005593456,
-0.00637654,
0.015135233,
-0.013272942,
-0.029586092,
-0.03203405,
0.008653405,
0.028006762,
-0.008627083,
-0.036614105,
-0.014608791,
0.023505677,
0.0075412947,
-0.018820334,
-0.0024002506,
-0.007179365,
-0.0065607945,
-0.024111085,
0.022755494,
0.01484569,
-0.0043332833,
-0.004547151,
0.009061399,
0.006294283,
0.015424777,
-0.0206234,
0.028743783,
0.013661194,
0.00039915065,
0.0055276505,
-0.001877098,
0.023650447,
-0.0024364437,
-0.008061157,
0.022531757,
-0.01728049,
0.004770889,
0.00041210608,
0.005922483,
0.0065344726,
0.0067713717,
-0.0050735935,
-0.037509058,
-0.0015497163,
0.0152800055,
-0.02638795,
-0.015398455,
0.000054238015,
0.008278315,
0.0037805182,
0.017978026,
0.017319972,
0.0032984938,
-0.0024512499,
0.014319248,
-0.011483036,
-0.0013243329,
-0.01227928,
0.020175925,
0.017859576,
-0.0049156607,
0.010094543,
0.013963898,
0.022676528,
0.009120624,
0.017978026,
-0.018794011,
0.027190777,
-0.018425502,
-0.004652439,
-0.01754371,
-0.04772205,
-0.007271493,
-0.0076400028,
-0.03695629,
-0.006524602,
0.0107131135,
-0.018267568,
0.07122772,
0.026203696,
-0.02330826,
-0.007179365,
-0.0035074258,
0.002355832,
-0.011417231,
0.02551932,
-0.020228568,
-0.020044314,
0.03645617,
-0.019912703,
0.043168318,
-0.038351364,
-0.007718969,
0.0022061248,
-0.007922966,
0.025466675,
0.017609516,
-0.019939026,
0.020162763,
-0.028454239,
0.008916627,
0.014385052,
-0.021373583,
0.018228086,
0.019702125,
-0.03508742,
-0.011509358,
-0.007054335,
0.010620986,
0.0017092943,
-0.052696936,
0.009133784,
-0.0131873945,
-0.01264121,
-0.019702125,
-0.0019544193,
-0.000030666328,
0.018122798,
0.00821909,
0.016030187,
-0.0059422245,
-0.02121565,
-0.011239556,
-0.009489133,
-0.028743783,
-0.0057086153,
-0.031612895
] |
Epigenetic mechanisms regulate gene expression, influencing protein levels and ultimately shaping phenotypes during life. However, both stochastic epigenetic variations and environmental reprogramming of the epigenome might influence neurodevelopment and ageing, and this may contribute to the origins of mental ill-health. Studying the role of epigenetic mechanisms is challenging, as genotype-, tissue- and cell type-dependent epigenetic changes have to be taken into account, while the nature of mental disorders also poses significant challenges for linking them with biological profiles. In this chapter, we summarise the current evidence suggesting the role of DNA methylation as a key epigenetic mechanism | [
-0.017448522,
-0.003653402,
0.0062938863,
-0.043125823,
-0.031083709,
0.018050628,
-0.007269172,
0.011026061,
-0.016269399,
-0.0152157135,
-0.013371765,
0.0042900033,
0.0008937507,
0.0055977018,
-0.014513257,
-0.0020587626,
0.054741446,
-0.0022876882,
-0.017272908,
0.02363265,
-0.035223186,
0.022440983,
0.019279927,
-0.02561458,
-0.029101776,
0.052031968,
-0.0015554398,
-0.044856876,
-0.012205184,
-0.013196151,
0.015378783,
0.010825359,
-0.014701415,
-0.010417683,
0.0003445644,
-0.013497204,
0.0049673724,
-0.019957297,
-0.003358621,
-0.023043089,
0.013798256,
0.0064005093,
-0.003251998,
-0.011734789,
0.005676101,
0.008749349,
-0.0031093117,
-0.0068740402,
-0.005745092,
0.02784739,
0.010649745,
0.027671775,
-0.003926231,
0.0013241622,
-0.008648998,
-0.026818793,
0.00709983,
-0.00096195797,
0.021010982,
-0.0075451373,
0.0029305615,
-0.004779214,
-0.015504222,
0.0068552247,
-0.023707913,
0.015604573,
0.02285493,
0.010216981,
0.004716495,
0.0072378125,
0.023845896,
0.01919212,
-0.013434484,
-0.0053530964,
0.0070433826,
-0.011496456,
-0.0080845235,
-0.018238787,
0.008774436,
0.010693649,
0.0077082077,
-0.017160013,
0.0006158256,
0.030807743,
0.0042021964,
-0.007770927,
-0.0023315917,
-0.005099083,
0.01996984,
-0.0026091249,
-0.010323605,
0.009345182,
0.020245805,
0.01481431,
0.0068489527,
0.00032437663,
0.004973644,
0.008391849,
-0.015516766,
-0.0011391401,
-0.03627687,
0.028123355,
-0.007212725,
-0.0006612971,
-0.03973898,
0.0013853136,
0.014663783,
-0.0136979055,
0.020220717,
0.0006354254,
-0.022390807,
0.010649745,
-0.0049611004,
-0.03148511,
0.029703882,
0.02412186,
0.0020822822,
-0.0028380505,
0.0016228631,
0.01212365,
0.004133205,
0.028549846,
0.018088259,
-0.014187116,
0.016846417,
0.0076956637,
-0.027772127,
0.0014033454,
-0.007012023,
-0.010455315,
-0.000286157,
-0.0044593457,
-0.0034621079,
0.012562685,
-0.0577018,
0.003264542,
0.010511762,
-0.007507506,
-0.020672297,
-0.026919143,
0.014713959,
0.0119793955,
-0.043075647,
-0.00172635,
-0.004123797,
0.023933703,
0.0153160645,
0.023268877,
0.02262914,
0.00030810878,
0.0033021737,
0.0009964536,
0.014789222,
0.0026467564,
0.008580007,
0.023870984,
0.012832378,
0.02629195,
-0.045408808,
-0.0054314956,
0.0043903543,
-0.019279927,
-0.013911151,
0.01591817,
0.005757636,
0.027094757,
-0.005757636,
-0.016068697,
0.026041072,
-0.018263873,
-0.01757396,
0.013823343,
-0.03715494,
0.0017483018,
-0.004506385,
0.004305683,
0.005262153,
0.021751069,
-0.029277392,
-0.027345635,
0.0021512737,
0.027345635,
0.014889573,
0.0070433826,
-0.0009941016,
-0.002601285,
0.015955802,
0.0068552247,
0.0075702253,
-0.025338616,
-0.011302026,
0.0060116495,
-0.012004483,
-0.009872025,
-0.63622504,
-0.027019495,
0.0112581225,
-0.015717467,
0.005497351,
0.020634664,
-0.008630182,
0.021725982,
-0.013058168,
0.045007404,
-0.008987682,
0.022842387,
0.006315838,
-0.02081028,
-0.0153035205,
-0.05413934,
-0.006648251,
-0.035273362,
0.026567915,
-0.0035248273,
-0.023055632,
0.004591056,
-0.008937507,
0.0017827974,
-0.013196151,
0.02385844,
0.019618612,
-0.0031155834,
-0.0021324577,
0.029126864,
-0.021387298,
0.027872477,
-0.03680371,
-0.00048058698,
0.04438021,
-0.009878297,
0.031083709,
0.03718003,
-0.010279701,
0.023707913,
-0.020020016,
-0.022478614,
0.001821997,
0.01073128,
-0.006428733,
0.01747361,
0.0065855314,
0.012550141,
0.018226242,
-0.0049015167,
0.0049203327,
0.014162028,
-0.00013651258,
0.006325246,
0.024824318,
0.0070182947,
0.022829842,
-0.02674353,
0.017160013,
0.003178303,
-0.0066607944,
0.0064193252,
-0.015654748,
-0.020346155,
0.004252372,
0.016520277,
-0.016545363,
0.0053938637,
-0.014513257,
-0.006155904,
0.009338911,
0.04427986,
0.0034213404,
-0.015416415,
0.012280448,
0.022930194,
0.0070308386,
-0.0032488622,
-0.012343167,
0.020496683,
-0.022905106,
0.0026091249,
-0.032588974,
0.00010750488,
0.027997917,
-0.02340686,
0.006986935,
0.016683346,
-0.004725903,
-0.0039795423,
0.007890094,
-0.0064726365,
-0.0005593782,
-0.051078636,
-0.008799524,
0.0074636023,
0.0043088193,
0.009978648,
0.034595992,
-0.013396853,
-0.013798256,
-0.0070433826,
0.004804302,
0.03241336,
0.005848579,
0.013911151,
-0.016708434,
0.010580754,
0.06864005,
0.019167032,
0.008467112,
0.014325099,
-0.031811252,
0.010122903,
-0.022729492,
-0.01608124,
0.017323084,
-0.002961921,
-0.022917649,
-0.019756595,
0.00995356,
0.013296502,
-0.010975885,
-0.011396105,
0.02295528,
0.021487648,
-0.025175545,
0.006503996,
-0.007927725,
-0.013384309,
0.0038917353,
-0.0023284557,
0.026342126,
-0.027044581,
0.004007766,
0.007005751,
0.02129949,
-0.0127383,
-0.0034746518,
-0.019405365,
-0.02042142,
0.0051461225,
0.008605095,
0.011038605,
-0.025940722,
-0.0300802,
-0.028800724,
-0.015265889,
0.012920185,
-0.0013696337,
0.008128427,
0.014601064,
-0.018339137,
0.02606616,
0.0062844786,
0.004239828,
-0.018125892,
-0.019932209,
-0.0051304423,
-0.02674353,
0.009884569,
0.02995476,
-0.013860975,
-0.009552157,
-0.028298968,
-0.027245283,
-0.025677301,
0.014789222,
-0.0014707687,
-0.029653708,
0.0069054,
-0.00787755,
-0.012035843,
-0.0009878298,
-0.024109317,
0.018815804,
-0.0044624815,
0.009044129,
-0.0152282575,
-0.011853957,
-0.011295754,
-0.008705446,
-0.0055537983,
-0.014776678,
0.041745998,
0.010367508,
0.035900556,
0.0022375127,
0.023870984,
0.03740582,
-0.010091543,
0.054390218,
-0.012292991,
0.018665278,
0.015077731,
-0.036452483,
0.01851475,
-0.0027361314,
-0.0024695743,
0.022039577,
-0.00096587796,
-0.028775636,
-0.017072206,
-0.01598089,
0.01996984,
-0.01951826,
0.005889347,
0.0028631382,
-0.025175545,
0.007977901,
-0.009621148,
0.014525801,
-0.011577992,
-0.013835887,
-0.0022798483,
-0.0059740175,
-0.017686855,
0.0026608682,
-0.01147764,
-0.009445533,
0.019091768,
-0.01634466,
0.01546659,
0.0035185553,
-0.009633692,
0.036878977,
0.007193909,
0.00826641,
0.0046443674,
-0.023331597,
-0.0011234602,
0.006068097,
-0.013998958,
-0.00047274708,
0.016357206,
0.012299264,
-0.006717242,
-0.03128441,
0.02772195,
0.0015468159,
0.004565968,
0.0019286199,
0.012669308,
-0.0023833353,
0.030531777,
0.009219744,
0.050075125,
0.0046349596,
-0.016194135,
-0.001057605,
-0.01864019,
0.020609576,
-0.023093263,
-0.022039577,
-0.0020634665,
-0.008924963,
-0.0018000453,
0.004998732,
0.040642135,
0.012249088,
-0.010317332,
-0.013208695,
-0.019718962,
-0.024498176,
0.014463081,
0.0056165173,
0.008736805,
0.006422461,
-0.015504222,
-0.0008365193,
-0.030958269,
0.0039638625,
-0.0043778103,
-0.01546659,
0.02136221,
-0.011954308,
0.007739567,
0.014488169,
0.0152157135,
0.0153160645,
0.0012779067,
-0.009765402,
0.027872477,
0.02872546,
-0.003835288,
0.0021450017,
-0.010392596,
-0.0033962526,
-0.004892109,
-0.010354964,
0.0017012623,
0.027696863,
-0.003540507,
-0.020534314,
-0.023394316,
-0.00023539354,
0.011421193,
-0.0018988282,
0.0076956637,
-0.016269399,
0.022453526,
0.008975139,
-0.03261406,
0.012995449,
0.019894576,
0.02535116,
-0.016884048,
0.0037819766,
-0.008498471,
-0.031761076,
0.012550141,
-0.0034903316,
-0.006231167,
-0.014111853,
0.01251251,
0.009915928,
0.008511015,
-0.0033398052,
0.008799524,
0.015767643,
-0.016118871,
-0.034244765,
-0.019054137,
0.010549394,
0.049397755,
0.012920185,
-0.0021794974,
0.02213993,
0.013158519,
0.0007381283,
0.00009711699,
-0.028549846,
0.035097744,
-0.0261916,
-0.0025448375,
0.01348466,
0.0128386505,
0.00011289482,
0.0157551,
0.014538344,
0.014274923,
-0.0061903996,
-0.02236572,
-0.0152784325,
0.0031594872,
0.0072440845,
0.013120887,
0.030632129,
0.028976338,
0.0010325173,
-0.0038164721,
0.027872477,
-0.0038007924,
-0.024849406,
0.001237923,
0.009890841,
0.0120922895,
0.031660724,
-0.0025683572,
-0.009796762,
-0.0013053464,
0.0012144033,
0.025815282,
-0.0035060116,
0.012437247,
0.0027032038,
0.017185101,
0.0054409034,
0.013246326,
-0.009106849,
0.0152157135,
0.01442545,
-0.009476894,
-0.015403871,
-0.0000574764,
-0.028023005,
-0.008140971,
-0.030581953,
0.022691859,
0.010154262,
0.023030544,
-0.0036941695,
-0.011358473,
-0.00057741,
-0.0052119778,
-0.008448296,
0.006268799,
-0.009251104,
0.010235798,
-0.0065792594,
-0.0012645788,
0.005462855,
0.006748602,
-0.016545363,
0.0037725687,
-0.032237742,
-0.055293374,
0.0068238648,
0.009784218,
0.019944752,
0.004503249,
-0.027370723,
0.006108864,
0.03193669,
-0.0009305983,
-0.014626152,
0.0065667154,
-0.031334586,
0.01624431,
0.0050144116,
0.00674233,
-0.0137480805,
-0.0025730613,
0.008968866,
0.016005978,
-0.0015938554,
0.022202648,
0.010367508,
-0.020609576,
0.031786166,
0.020220717,
0.024335107,
0.010593298,
-0.010053911,
-0.0010364372,
-0.013434484,
-0.043451965,
-0.02535116,
-0.0011853956,
-0.03484687,
-0.022842387,
-0.0021747933,
-0.0035028756,
-0.023582473,
0.035950728,
-0.022415895,
0.006140224,
0.01397387,
0.008291498,
0.028198618,
0.0021246178,
0.018527295,
0.0025432694,
0.009658779,
-0.0020462186,
-0.022428438,
0.028073179,
0.0028129627,
-0.021199139,
-0.0041959244,
-0.0060994565,
-0.007977901,
-0.01806317,
0.01144628,
0.010906895,
0.030757567,
-0.020245805,
-0.029076688,
-0.014964836,
-0.0043778103,
-0.008122155,
0.0066796103,
0.01657045,
-0.01287001,
-0.0087932525,
-0.012136194,
-0.013773168,
0.0029525133,
0.043552313,
-0.04046652,
0.007902638,
0.02217756,
-0.0022469205,
0.018050628,
-0.017385803,
0.005378184,
-0.023043089,
-0.010819087,
-0.026593003,
-0.041118804,
0.019041594,
-0.0049611004,
0.041871436,
0.0009008066,
0.04302547,
-0.008159787,
0.010681105,
0.011640711,
0.0073569794,
-0.025526773,
0.014563432,
0.029478094,
-0.0063785575,
0.003753753,
0.0008341673,
-0.012957817,
0.01818861,
-0.032011956,
0.00975913,
0.027747039,
-0.0057858597,
-0.033316515,
0.0022359446,
-0.031986866,
-0.025451511,
0.02451072,
-0.011803781,
0.018715452,
-0.037104767,
0.008755621,
0.004694543,
0.005190026,
0.012568957,
-0.020270893,
0.00249623,
-0.020270893,
0.028474582,
-0.015115363,
0.0065918034,
-0.013886063,
-0.018590014,
0.002979169,
-0.0176994,
0.0076580322,
-0.015265889,
0.031685814,
-0.0052151135,
-0.007494962,
-0.00045197128,
0.017737031,
-0.015566941,
-0.018263873,
-0.024761599,
-0.011603079,
-0.0050551794,
-0.006986935,
0.0069054,
-0.028875986,
0.014525801,
0.004625552,
-0.008278954,
0.037104767,
-0.010706193,
-0.0035310993,
0.0153662395,
-0.0032206385,
0.006030465,
-0.01675861,
0.021562912,
0.023908615,
0.021650719,
-0.016131416,
0.011841413,
0.0020587626,
0.00228612,
0.04713986,
0.012637949,
-0.00632211,
-0.010085271,
0.0075576813,
-0.026542827,
-0.015579485,
-0.007777199,
-0.012819834,
-0.0014652808,
0.0005668261,
-0.0012888826,
0.0013053464,
-0.023733001,
0.006133952,
-0.026342126,
0.02340686,
-0.012205184,
-0.03635213,
0.0063942373,
0.004139477,
-0.004964236,
0.01591817,
0.012537598,
0.0020352427,
-0.017486153,
-0.010254613,
-0.010806544,
0.018564926,
0.0050144116,
0.036427397,
-0.009734043,
0.006315838,
0.006641979,
-0.004600464,
0.0071500055,
-0.012750844,
-0.011584263,
0.041896522,
-0.02674353,
-0.008968866,
0.0152909765,
-0.011747333,
0.0056917807,
-0.00095333403,
0.003446428,
-0.035198096,
-0.017862469,
-0.011107597,
-0.0045628324,
0.017837383,
-0.004979916,
-0.00810334,
-0.019882033,
-0.0069555757,
-0.021261858,
-0.018176066,
0.012299264,
-0.022992913,
0.030431427,
0.0018329729,
0.032262832,
0.030883007,
0.012261632,
0.00937027,
-0.012318079,
0.011935492,
-0.0017608457,
0.0300802,
0.024824318,
-0.009501981,
0.0051461225,
0.019442998,
-0.02684388,
-0.017134925,
-0.0050551794,
-0.015152994,
-0.03971389,
0.011715974,
-0.008730533,
0.026492652,
0.0063189743,
-0.008341673,
-0.0068614963,
-0.0027345635,
0.003653402,
-0.0063848295,
-0.023482123,
0.007306804,
-0.02246607,
0.008830884,
0.015880538,
-0.011408649,
-0.017423434,
-0.016407382,
-0.00045314728,
0.010122903,
-0.0097026825,
0.0022939602,
-0.011816325,
0.0076204007,
0.004810574,
0.01591817,
-0.0017467338,
-0.008166059,
-0.01442545,
0.01144628,
-0.0018784445,
0.009552157,
-0.013472116,
0.02696932,
0.0341695,
0.00018345409,
-0.0048544775,
-0.00004919549,
-0.0028427544,
-0.03770687,
-0.04269933,
-0.008404393,
-0.025815282,
0.0112706665,
0.033793185,
-0.0052245217,
-0.024197124,
-0.0036063625,
-0.040315997,
-0.019731507,
0.023507211,
0.002126186,
0.030280901,
0.014224748,
0.0045408807,
-0.0076768477,
0.0012998584,
0.017824838,
-0.0038854636,
-0.006817593,
0.004358995,
-0.01598089,
-0.0021653855,
0.017548872,
-0.014011502,
0.003054432,
0.03326634,
-0.024146948,
-0.02706967,
-0.0046569114,
-0.0018423809,
0.021010982,
-0.02129949,
0.009633692,
0.0011814757,
0.0028396184,
0.029804233,
-0.021148963,
-0.0051304423,
-0.011722246,
-0.0040548057,
-0.01724782,
0.004098709,
-0.0069493037,
-0.017900102,
0.0041896524,
-0.018163523,
-0.021826332,
0.02129949,
-0.017498698,
0.03916196,
0.027897565,
0.015604573,
0.01497738,
-0.009088033,
-0.011985667,
-0.010668561,
-0.011458824,
-0.016219223,
0.0040642135,
0.005836035,
0.0010936686,
-0.016608084,
0.0046663196,
-0.006999479,
-0.02139984,
0.0000069763023,
-0.0037286652,
-0.025075195,
-0.012186369,
-0.0015985593,
-0.0006338574,
-0.0038509679,
-0.014450537,
-0.020559402,
-0.03306564,
-0.014877029,
-0.010380052,
-0.0121299215,
-0.01721019,
0.0054942146,
-0.0152909765,
-0.0026593003,
0.011427465,
-0.0014433289,
0.001342978,
-0.008122155,
0.006554172,
0.17400855,
-0.018941242,
-0.031359673,
0.00012945665,
0.001144628,
-0.027144933,
0.036552835,
0.0022343767,
-0.0001248507,
-0.0058862106,
0.006748602,
0.004600464,
-0.018000452,
0.0071311896,
0.035047572,
-0.031359673,
-0.027521249,
0.008354217,
-0.006315838,
0.007770927,
0.01348466,
-0.013396853,
-0.0010913166,
0.0038823276,
0.03871038,
0.005064587,
-0.034595992,
0.017373258,
0.010518034,
0.0011603079,
-0.02207721,
0.015052643,
0.017636681,
0.007212725,
-0.016808785,
0.0010199734,
-0.009708955,
-0.011791237,
-0.00033104056,
-0.023331597,
0.029051602,
0.010430227,
-0.006616891,
-0.0128135625,
0.007821103,
0.006344062,
-0.0119793955,
-0.0076204007,
-0.023005456,
-0.004904653,
-0.041219153,
-0.0076266723,
-0.002891362,
0.020082735,
0.0013335701,
-0.0046757273,
0.005550662,
0.017774662,
0.00011024885,
0.0044875694,
-0.025990898,
0.0037662967,
-0.04039126,
0.016746065,
-0.0033178534,
0.026768617,
-0.013434484,
-0.005403272,
0.004098709,
-0.015830362,
-0.013848431,
-0.00502382,
-0.002870978,
0.013145975,
-0.009859481,
-0.023983877,
0.05589548,
0.011082509,
0.008473383,
0.02784739,
0.0064789085,
0.006447549,
-0.028148443,
0.0033523492,
-0.0046882713,
-0.055393726,
0.036628097,
0.0070621986,
-0.0370295,
-0.004123797,
0.003537371,
-0.0011603079,
-0.002389607,
-0.0057043247,
0.019330103,
-0.009915928,
0.008824612,
0.012788475,
-0.015554398,
-0.013522291,
-0.040893015,
0.083843224,
-0.009131936,
0.016169047,
0.0055004866,
0.019618612,
0.0033272614,
0.015328608,
0.004406034,
-0.0025197498,
0.0059959693,
-0.014839398,
0.019693874,
-0.007400883,
-0.0048356615,
0.03140985,
0.0062907506,
-0.028800724,
0.036477573,
-0.020847911,
-0.0032363182,
-0.019468086,
-0.0032331822,
0.013534835,
-0.0018627646,
-0.0015154562,
-0.0073569794,
0.011665799,
-0.016231766,
-0.0331409,
-0.00025499336,
-0.0047823503,
-0.0051210346,
0.011784965,
-0.012719483,
-0.02367028,
0.0331409,
-0.0011556039,
-0.0064130533,
0.024598528,
-0.007965357,
-0.013409397,
-0.003070112,
0.0072252685,
-0.005469127,
-0.03115897,
0.0072629005,
0.028198618,
0.0044624815,
-0.0135975545,
-0.0051335786,
-0.018000452,
0.015002468,
0.019668788,
0.0066733384,
-0.031786166,
-0.02009528,
-0.036327045,
-0.024422914,
-0.006723514,
-0.031359673,
0.026593003,
0.003932503,
-0.0042837313,
0.00210737,
0.023018,
-0.15233275,
0.004120661,
0.0061778557,
-0.025137914,
0.037004415,
0.019618612,
0.007181365,
-0.015265889,
0.015642205,
0.01847712,
0.016608084,
-0.010336149,
-0.03858494,
-0.022127386,
0.023808263,
0.005331144,
0.0044593457,
0.02895125,
0.0017467338,
-0.0011407081,
-0.0016103192,
-0.0061809914,
0.029653708,
0.0055349823,
0.017461065,
0.023946246,
0.00092667836,
0.0003733761,
-0.019066682,
-0.017097294,
-0.019367734,
-0.0039168233,
0.02064721,
0.022754578,
0.026015984,
0.005262153,
0.010223254,
-0.011615623,
-0.015391327,
-0.007407155,
0.022829842,
0.032764588,
-0.015378783,
0.00034750436,
0.0018314049,
0.029151952,
0.000038660597,
-0.031610552,
0.012907641,
0.027671775,
0.0069116717,
0.010975885,
-0.0052276575,
-0.0061464957,
0.03635213,
-0.01591817,
0.008529831,
0.020045104,
0.0033272614,
-0.020170541,
-0.023444492,
-0.025865458,
0.02827388,
0.017837383,
0.021600543,
-0.0044436655,
-0.010900622,
0.023431947,
-0.042072136,
-0.0037161212,
-0.013409397,
-0.0038697836,
0.013384309,
-0.0054942146,
0.023921158,
-0.007990445,
0.0017373259,
-0.0005150826,
-0.015152994,
0.0035750028,
-0.018326594,
-0.0014621448,
-0.016871504,
-0.01663317,
-0.019330103,
0.006529084,
0.0055098943,
0.0136477295,
-0.008260138,
0.0010207574,
0.010706193,
-0.02518809,
0.020709928,
0.009853209,
0.039538275,
0.0021622495,
0.0060273292,
0.0011650119,
0.011941764,
-0.0017012623,
0.009495709,
-0.0071625495,
-0.017109837,
0.0017043982,
0.028048092,
-0.008423208,
-0.022277912,
0.013760624,
0.037205115,
0.009232288,
-0.013133431,
0.003261406,
-0.008448296,
0.02146256,
-0.008366761,
0.046437405,
-0.014739047,
-0.0058673946,
-0.0028600022,
0.020571945,
0.08283971,
-0.010110359,
0.0068552247,
0.020157998,
-0.016846417,
-0.03128441,
-0.14841907,
-0.01206093,
-0.008297769,
0.0048576132,
0.022566421,
-0.0034558359,
0.0048231175,
0.016106328,
-0.0041802446,
0.02512537,
-0.022353174,
0.0057858597,
-0.010242069,
-0.039212134,
-0.005397,
-0.01608124,
0.004691407,
0.0007863438,
-0.026793705,
0.039663713,
-0.005842307,
-0.016871504,
-0.015178082,
-0.010668561,
0.0061715837,
0.021199139,
-0.03125932,
0.0070308386,
0.0023112078,
-0.008586278,
0.0019960431,
-0.012537598,
-0.0038164721,
0.00004530003,
-0.010913166,
-0.0087932525,
0.030004935,
-0.02129949,
0.025401335,
0.0033178534,
-0.020872999,
0.0024335107,
0.03582529,
0.0040673497,
0.0019631155,
-0.008975139,
-0.017373258,
0.0038948713,
0.00047392305,
0.0028255065,
-0.042122312,
0.0011626598,
-0.013246326,
-0.023143439,
0.018364225,
-0.02817353,
-0.0022767123,
0.01870291,
-0.009583516,
0.006999479,
-0.0019725235,
0.0070371106,
-0.01919212,
-0.014538344,
0.0164701,
-0.009000226,
-0.024335107,
-0.025765108,
0.020847911,
-0.02525081,
0.010191894,
0.016294487,
0.0024727103,
0.0049673724,
-0.037079677,
0.026894055,
-0.019631155,
-0.03359248,
0.0073256195,
-0.015165538,
0.0019834994,
-0.009326367,
0.0053154645,
-0.014877029,
0.03627687,
0.0053123287,
-0.013133431,
0.002980737,
-0.00013572858,
0.0112832105,
-0.029126864,
0.035724938,
-0.007977901,
-0.014776678,
-0.0053405524,
-0.0038823276,
-0.01144628,
-0.00975913,
0.017937733,
0.008304042,
-0.0120421145,
-0.01248115,
-0.028700372,
0.012493694,
-0.024335107,
-0.0044812975,
-0.0021873373,
-0.0009008066,
0.022491157,
-0.0038917353,
0.002405287,
0.010681105,
-0.0068677682,
0.008824612,
0.009765402,
-0.006231167,
-0.019919664,
-0.02195177,
0.033793185,
-0.0039920863,
0.007407155,
0.04026582,
0.006510268,
-0.0020462186,
-0.0028302106,
0.022654228,
-0.021826332,
-0.00943299,
-0.015805276,
0.0037255292,
-0.01419966,
-0.0011352202,
0.013923695,
-0.037104767,
-0.0039575906,
-0.005930114,
-0.013058168,
-0.01779975,
0.016896592,
0.029001426,
0.020371243,
0.047190037,
-0.014036589,
-0.018615102,
-0.010198166,
-0.017097294,
0.0018031813,
0.008630182,
-0.05489197,
0.002497798,
0.008247594,
-0.014914661,
0.05368776,
0.0153662395,
-0.007112374,
-0.018552383,
-0.0011320842,
-0.010612113,
-0.008335401,
0.020923173,
-0.002386471,
-0.015479134,
0.0067925053,
0.025915634,
-0.005848579,
-0.012713212,
-0.009363999,
-0.00039846386,
-0.016821329,
0.011239307,
0.0046631834,
-0.026367214,
-0.016219223,
0.012330623,
0.0196437,
0.00790891,
-0.006817593,
-0.020283436,
0.0069116717,
0.010549394,
-0.031209147,
0.050200563,
0.018376768,
0.009320095,
-0.006817593,
0.0070433826,
0.04094319,
0.0054220874,
-0.027546337,
0.019593524,
-0.0040548057,
-0.00057741,
-0.00086944696,
0.0049454207,
0.016093785,
0.03469634,
0.0058736666,
0.002486822,
-0.020735016,
0.006974391,
0.00810334,
0.010674832,
0.011678343,
0.0027674912,
0.0040234462,
-0.020935718,
-0.004957964,
0.038534768,
-0.024523264,
-0.02068484,
0.003935639,
0.020245805,
-0.011226763,
0.015127907,
-0.017222732,
-0.015554398,
-0.029277392,
0.027922653,
-0.019806769,
-0.0009086465,
-0.011803781,
0.02629195,
-0.00008815008,
0.0030371842,
0.0049234685,
-0.0121048335,
0.03093318,
-0.0009282463,
0.0052433372,
0.0005609462,
0.025050107,
0.005111627,
0.019530805,
0.0042021964,
-0.023833351,
0.0015413279,
-0.0048199818,
-0.025915634,
-0.00019501797,
0.024698878,
-0.015604573,
0.07019549,
0.016896592,
-0.012637949,
0.0015577917,
0.0031140156,
0.037782133,
0.0010772048,
0.036101256,
-0.021424929,
-0.009602332,
0.020070191,
-0.041545294,
0.028248794,
-0.03861003,
0.0024507584,
0.038986344,
-0.016670803,
0.038183536,
-0.010756368,
-0.016808785,
0.005751364,
-0.010649745,
0.005735684,
0.009219744,
-0.030732479,
0.002982305,
0.037556343,
0.0036063625,
0.0058799386,
-0.0050332276,
-0.0057325484,
-0.0052276575,
-0.030983357,
0.012324352,
0.008686629,
-0.012844922,
-0.025915634,
-0.019693874,
0.0076831197,
0.021424929,
-0.0067925053,
-0.019656243,
0.0064789085,
-0.029202128,
-0.0012387071,
-0.022767123,
0.0026969318,
-0.017849926,
-0.0315102
] |
The twin-arginine translocation (Tat) system transports folded proteins across bacterial plasma membranes and the chloroplast thylakoid membrane. Here, we investigate the composition and structural organization of three different purified Tat complexes from Escherichia coli, Salmonella typhimurium and Agrobacterium tumefaciens. First, we demonstrate the functional activity of these Tat systems in vivo, since expression of the tatABC operons from S.typhimurium or A.tumefaciens in an E.coli tat null mutant strain resulted in efficient Tat-dependent export of an E.coli cofactor-containing | [
-0.012765976,
-0.02304103,
-0.00574672,
-0.021145763,
-0.010999316,
0.036389124,
-0.01774782,
-0.012569681,
-0.029891066,
0.0016016697,
0.018925592,
0.008623464,
0.008312099,
0.041804172,
0.008122572,
-0.011831881,
0.021606041,
-0.00008672538,
-0.027427219,
-0.0041289744,
-0.022025708,
-0.0014654474,
-0.0037363833,
0.0027481369,
-0.0045351028,
0.0196837,
0.03766166,
-0.03622667,
-0.019616012,
-0.022269385,
0.0031187292,
-0.012752438,
-0.028510228,
0.000047090824,
-0.018384088,
-0.028645605,
0.01666481,
-0.009097281,
0.025965156,
0.0011041622,
0.03766166,
0.014268652,
0.0037803804,
0.0064100632,
-0.0015297511,
-0.0066909688,
-0.0142280385,
-0.0062611494,
-0.0169491,
0.032490287,
0.006213768,
0.018113336,
-0.027995799,
-0.0033404077,
-0.015392275,
-0.0022590903,
-0.012549374,
0.016570047,
-0.008163185,
-0.019724313,
0.0060953135,
-0.011242993,
-0.03181341,
0.015987929,
-0.009022824,
0.00023669683,
0.017152164,
0.0011523899,
0.012082326,
0.014728931,
0.037174307,
0.025342425,
0.004937847,
-0.0076758307,
0.039177872,
-0.032273687,
-0.025924543,
0.0056451876,
-0.021457128,
0.01950771,
0.0073983097,
-0.03611837,
-0.0016888181,
0.017301079,
0.009415415,
-0.010159984,
0.013409013,
0.027752122,
-0.0047517046,
-0.002215093,
0.036199596,
0.039719377,
0.00030290426,
0.011635585,
-0.011940181,
0.014552942,
-0.002974892,
0.0393674,
-0.012048482,
-0.03232784,
-0.018952668,
-0.0016473591,
-0.014146813,
-0.01650236,
-0.03798656,
0.010078758,
0.012589986,
0.0016972792,
0.014404028,
-0.030567946,
-0.012468148,
0.053744353,
-0.006274687,
-0.03823024,
0.015229823,
0.015920242,
0.018465314,
-0.008352712,
-0.0037973025,
-0.011635585,
0.004937847,
0.024327103,
0.0074659977,
-0.022404762,
0.03595592,
0.012461379,
0.008697921,
-0.011215919,
-0.008406863,
-0.009205582,
-0.0009552483,
0.01991384,
-0.011669429,
0.0045418716,
-0.020847935,
0.008183491,
-0.04258935,
-0.009659092,
-0.014376952,
-0.0058347145,
0.009009286,
0.018871443,
-0.022905653,
0.009205582,
-0.0028175171,
0.016976176,
0.030486722,
0.03503536,
0.0064134477,
0.013903136,
0.017138626,
-0.013036728,
0.0051679867,
-0.014376952,
0.00083087146,
0.03590177,
-0.018817293,
0.019575398,
-0.012129708,
-0.017612444,
0.0082241045,
0.018045647,
-0.00044378013,
-0.0101938285,
0.036876477,
0.03246321,
-0.0005021611,
0.0072967773,
0.0015737483,
-0.016123306,
0.0039089876,
-0.0073983097,
-0.012021407,
0.015690101,
0.003560394,
0.005797486,
0.008406863,
0.008934829,
-0.028483152,
-0.026614962,
0.014417565,
0.03100115,
0.03181341,
0.00401052,
-0.009340958,
-0.025274737,
0.011094079,
0.010816558,
0.018641302,
-0.018343475,
-0.014783082,
0.009909538,
0.002715985,
-0.011906337,
-0.6316112,
-0.03430433,
0.013260099,
-0.038717594,
0.0005740797,
0.018600691,
0.0045791,
-0.0037533052,
-0.021402977,
0.025789166,
-0.03503536,
0.00898898,
-0.012657675,
-0.006288225,
-0.012813358,
-0.034575082,
0.013930211,
-0.014079125,
0.043780662,
0.019643087,
-0.032246612,
-0.006047932,
0.0068297293,
0.015243361,
0.010586419,
0.013361631,
0.035116587,
-0.021511279,
-0.03037842,
0.021917406,
-0.01563595,
0.029160034,
0.002624606,
-0.013334556,
0.040910687,
0.0017319693,
-0.0026787566,
0.019670162,
0.012359847,
0.029593239,
0.005641803,
-0.02122699,
0.020956237,
0.014931995,
0.0033776362,
0.024584318,
0.01911512,
-0.004914156,
-0.016001467,
-0.00024706157,
0.004964922,
0.011127924,
-0.0054285857,
0.0021203298,
0.004687401,
0.018790217,
0.018857906,
-0.0024333873,
0.012488455,
-0.0011464672,
-0.015717177,
0.017896734,
-0.014187426,
-0.007831513,
0.0032354912,
-0.00910405,
-0.0116965035,
0.022188159,
0.0102885915,
0.0052153682,
-0.010024608,
0.034168955,
-0.004318501,
0.01467478,
-0.0045249495,
0.03647035,
-0.0048566214,
0.013172105,
0.0010940089,
0.022567213,
-0.014931995,
0.00825118,
-0.0017150473,
0.000010186266,
0.03993598,
0.027562594,
-0.03021597,
0.040098432,
0.008948367,
-0.010051683,
-0.0052018305,
0.01154759,
-0.017422916,
-0.023880363,
-0.025735017,
0.010884247,
-0.018884981,
-0.009381571,
0.013612078,
-0.016989714,
-0.022607826,
-0.008129341,
0.026966939,
-0.0056079593,
0.00026927172,
0.007174939,
-0.0224183,
0.008034578,
0.03533319,
0.0059768595,
-0.020441806,
-0.0070666377,
-0.026059918,
-0.027170004,
-0.011913106,
-0.028889282,
0.020157516,
0.023217019,
0.00825118,
-0.030188894,
0.010951934,
-0.005536887,
0.010315667,
-0.01746353,
-0.0058617895,
0.042291526,
0.024015738,
-0.042047847,
-0.02593808,
0.004995382,
-0.019426486,
0.026682649,
0.017368767,
-0.013050266,
0.011222688,
0.015229823,
0.0010973933,
0.004352345,
-0.0024215418,
-0.022837965,
-0.018587153,
-0.015013221,
0.00010703181,
0.008129341,
-0.016434671,
-0.033708673,
-0.010742102,
-0.010999316,
-0.019710775,
-0.0049919975,
-0.0010330896,
0.024963371,
-0.034548007,
-0.005624881,
0.022120472,
-0.021809107,
-0.04375359,
-0.029999366,
-0.0049750754,
-0.023785599,
0.013727147,
0.018194562,
-0.015717177,
0.0012192319,
-0.010965472,
-0.00029127035,
0.0009425568,
0.0013833756,
-0.014864307,
-0.038771745,
0.016529433,
-0.023135792,
-0.0084610125,
0.012420767,
-0.002213401,
0.020401193,
0.00039893674,
-0.01001107,
0.008339174,
-0.0025044598,
-0.01973785,
-0.011019623,
-0.006677431,
-0.008400094,
0.018587153,
0.004460646,
0.011141461,
-0.0029224337,
0.0031779564,
0.041912474,
-0.0033454844,
0.010613495,
-0.00477878,
0.0036450042,
0.0062239207,
-0.008521932,
0.015825478,
0.02298688,
0.012657675,
0.016908487,
0.00100263,
-0.020712558,
-0.003560394,
-0.042047847,
0.0121161705,
0.0018884981,
-0.003658542,
-0.0047246297,
0.017558293,
0.010457812,
0.0013546081,
-0.011229456,
-0.015987929,
-0.006318684,
-0.0031948783,
0.018302863,
-0.001370684,
0.0077909003,
-0.005354129,
-0.024300028,
-0.010748871,
-0.003066271,
-0.005689185,
-0.0018868059,
-0.019318184,
-0.010951934,
0.02383975,
-0.007743519,
-0.017531218,
-0.00429481,
0.0007589528,
0.011215919,
0.009564329,
0.028320702,
0.025491338,
-0.008359481,
0.012732131,
0.006535286,
0.038528066,
-0.008393325,
0.0035130125,
0.0050732233,
-0.0039800606,
-0.02270259,
0.0077638254,
0.015717177,
0.011371601,
0.029484937,
-0.008941598,
-0.007249396,
-0.0009205582,
0.025491338,
-0.034602158,
-0.009571098,
-0.015365199,
-0.0010119372,
-0.005330438,
0.012908121,
0.050468247,
0.011067005,
0.0046772477,
0.017368767,
-0.010762408,
-0.0044741835,
-0.004744936,
0.017341692,
-0.0057873325,
-0.01661066,
-0.0046467884,
0.009835081,
-0.011561127,
0.0070192562,
0.014295727,
-0.0118386485,
0.01171681,
0.012610293,
-0.007926277,
0.014701855,
-0.0020187977,
-0.005245828,
-0.008731765,
-0.034602158,
0.02878098,
0.015283973,
-0.007134326,
-0.008907754,
-0.008691153,
-0.011919875,
-0.022837965,
0.017991498,
-0.014092662,
0.014931995,
0.023244094,
0.0282124,
-0.015297511,
-0.0030222738,
0.0135240825,
-0.025450727,
0.037905335,
-0.0109451655,
0.00143668,
-0.009401877,
-0.018952668,
0.006951568,
0.060052883,
0.014931995,
-0.0011473133,
0.022255847,
0.0001090413,
-0.030649172,
0.014376952,
0.012150014,
-0.010911322,
-0.021213451,
-0.01735523,
-0.0116965035,
-0.019697238,
0.0043218853,
0.016272219,
-0.0034487087,
-0.024733232,
-0.030134743,
-0.0042981943,
0.016109768,
0.022404762,
0.026777413,
-0.006318684,
0.015283973,
0.0022709358,
-0.01353762,
0.010511962,
-0.03219246,
0.016840799,
-0.0037499208,
-0.0020983312,
-0.025518414,
0.015107985,
-0.0021321753,
0.008637002,
0.024327103,
-0.016001467,
-0.005580884,
0.012664444,
0.009246195,
0.028131176,
-0.005993781,
-0.005733182,
0.009808006,
0.013889599,
-0.01973785,
0.020604258,
0.024029275,
0.025951618,
-0.024773845,
0.01245461,
0.0030171971,
0.009510178,
-0.0017243543,
-0.0015644412,
-0.024584318,
-0.018045647,
0.026804488,
-0.004460646,
0.017883196,
0.020739634,
0.020184591,
0.014715393,
-0.013916674,
-0.020184591,
-0.0118386485,
-0.0040071355,
0.0022929343,
-0.022648439,
-0.021944482,
0.028185325,
-0.0023453927,
-0.026114069,
-0.03522489,
0.0029088962,
0.0048566214,
-0.019182809,
-0.007797669,
0.009950151,
-0.013591771,
0.0045554093,
-0.013794835,
0.023217019,
-0.006978643,
0.0055335024,
-0.0031102682,
0.0006218844,
-0.017287541,
-0.024394792,
0.0029681232,
-0.0015187517,
-0.036145445,
-0.011283606,
-0.016542971,
0.03078455,
0.008637002,
-0.0016202839,
-0.008569313,
-0.0048430837,
0.02503106,
-0.009144663,
-0.0120687885,
-0.009936613,
-0.041208517,
-0.006917724,
-0.0064879046,
0.029376635,
-0.024015738,
-0.027156467,
0.0039225253,
0.023122255,
-0.012217702,
0.011933412,
-0.0032473367,
-0.0046907854,
0.017152164,
0.021199914,
0.012007869,
-0.012650906,
-0.0025264584,
-0.011764192,
-0.031921707,
0.00006906302,
-0.02172788,
0.008921292,
-0.015500575,
-0.0021541738,
-0.007026025,
-0.011337757,
-0.016542971,
0.0034080958,
-0.0028141327,
-0.026262984,
0.015487038,
0.015270435,
0.027508445,
-0.005371051,
0.0018597306,
-0.00257384,
0.0133684,
-0.018140411,
0.0052322904,
0.019588936,
0.0052695186,
-0.010606726,
0.0104307365,
0.015866091,
-0.0281041,
-0.01870899,
0.012989347,
-0.003959754,
0.009814775,
0.006122389,
-0.0021524816,
-0.02138944,
-0.0079939645,
-0.015419349,
0.0001282901,
0.009794468,
-0.0133684,
-0.014024975,
0.011026392,
0.0037769962,
0.005181524,
-0.017653057,
-0.028645605,
-0.0025078442,
-0.0005288133,
-0.0010356279,
0.02997229,
0.017558293,
-0.007046331,
-0.020279355,
-0.0013385322,
-0.016813725,
-0.056912154,
-0.007195245,
-0.012928427,
0.042101998,
0.035685167,
0.03419603,
-0.014701855,
0.02622237,
0.03465631,
-0.005394742,
0.006288225,
-0.003008736,
0.012238009,
-0.023298245,
0.0025179973,
0.009516947,
-0.015730714,
0.00077164435,
0.000044103028,
0.008183491,
0.014877845,
-0.0065555926,
0.005888865,
0.0014984453,
-0.024868608,
-0.01678665,
0.000559696,
-0.0019104966,
-0.0018157333,
-0.0423186,
-0.004267735,
0.020929161,
0.0017311232,
0.018465314,
-0.0010593188,
0.026980476,
-0.013760991,
0.020739634,
0.0038108402,
0.008312099,
-0.0019934145,
-0.024476018,
-0.0074253846,
-0.014282189,
0.025342425,
-0.002981661,
-0.016245143,
-0.0022455528,
-0.0062205363,
-0.0043083476,
0.007026025,
-0.006007319,
0.0016702039,
-0.008359481,
0.0020069522,
-0.020631334,
-0.015365199,
-0.009753855,
-0.059457228,
0.003952985,
-0.0070395623,
-0.011473133,
0.0004446262,
-0.012048482,
-0.0038785283,
0.019169271,
0.001562749,
0.029701538,
0.006416832,
0.012434304,
0.024300028,
0.0036619264,
-0.0140385125,
-0.012833664,
-0.003106884,
0.012596755,
0.0153516615,
0.029295411,
-0.014079125,
-0.025951618,
0.006572515,
0.00790597,
-0.023189943,
-0.033464998,
0.023447158,
-0.009029592,
0.014769544,
-0.008887447,
0.0026787566,
-0.009983995,
0.014525866,
-0.0020560261,
0.0054793516,
0.008494857,
0.009638785,
-0.019792002,
0.0016287449,
0.020996848,
0.033654522,
0.010599957,
-0.014512329,
0.0028462848,
-0.025843317,
-0.005513196,
-0.011743885,
0.0044437237,
0.022607826,
0.018587153,
0.012183858,
0.01769367,
0.027779197,
-0.017950885,
-0.013503776,
-0.016475284,
0.03698478,
-0.00955756,
-0.009808006,
0.007026025,
0.031921707,
0.010816558,
-0.015622414,
0.014295727,
-0.010660876,
-0.03714723,
-0.00984185,
0.027373068,
0.017598907,
-0.004260966,
-0.015297511,
-0.017964423,
0.013842217,
-0.014214502,
-0.025166435,
0.009171737,
-0.0677964,
-0.024990447,
0.018289326,
-0.006355913,
0.02748137,
-0.014173889,
0.017084477,
-0.01563595,
0.0480044,
-0.0211593,
0.010782715,
0.011608509,
0.010335973,
-0.018763142,
-0.017016789,
-0.0038243777,
-0.005313516,
0.011770961,
-0.014877845,
-0.0049581532,
-0.002546765,
-0.012501992,
0.016773112,
0.029322486,
-0.024787383,
0.010708258,
-0.009293577,
0.009692936,
-0.007702906,
0.006433754,
0.0031525732,
-0.026073456,
0.023596073,
0.013070572,
-0.0063863723,
-0.003516397,
0.0028479767,
-0.02355546,
-0.00412559,
0.012644137,
-0.016366983,
-0.018397626,
-0.0066909688,
-0.013503776,
-0.006355913,
0.0251529,
-0.004250813,
0.0012192319,
0.0054725828,
0.005530118,
-0.010105833,
-0.011730348,
0.002482461,
0.011872493,
-0.0031153448,
-0.031244827,
-0.0069075706,
0.018411163,
-0.012278622,
-0.024191728,
0.0043997266,
-0.0033184092,
0.0142280385,
-0.009137894,
-0.052255213,
-0.0007428769,
-0.009395109,
-0.040125508,
-0.021660192,
-0.00830533,
0.0068635736,
-0.0036450042,
0.009340958,
-0.008203798,
0.0039631384,
-0.011418982,
0.021578968,
0.006873727,
-0.0013055343,
0.009618479,
-0.0068804957,
-0.009983995,
0.0090702055,
-0.065792836,
-0.025680866,
0.040423334,
-0.0060817758,
-0.012251547,
0.013862523,
-0.022973342,
0.024827996,
-0.012386923,
0.00006763522,
-0.018045647,
0.0026804488,
0.035739318,
-0.0183164,
-0.0068331137,
0.008792684,
0.015608876,
-0.016015004,
0.009591404,
0.011960488,
0.030188894,
-0.005963322,
-0.014444641,
-0.04659649,
-0.0029275103,
0.009368033,
0.014972608,
0.036849402,
-0.0063525285,
0.0008909446,
0.030567946,
-0.0071140192,
-0.005371051,
-0.0028682833,
-0.021538354,
-0.01973785,
-0.011500209,
0.0020424884,
-0.00060369325,
0.009692936,
-0.0055199647,
0.0009933229,
-0.003516397,
0.010667644,
-0.010938398,
-0.013348093,
0.0020238743,
0.01661066,
-0.013760991,
0.0011143154,
0.0018698839,
-0.0267368,
0.008718227,
0.00018741142,
0.011053467,
-0.0169491,
-0.003651773,
-0.01382191,
-0.01041043,
-0.012150014,
-0.00688388,
-0.0039834445,
-0.020225205,
-0.0075066104,
0.17512265,
-0.033437923,
-0.0037533052,
0.02531535,
-0.015825478,
-0.008914523,
-0.010322436,
-0.0006608051,
0.008806222,
0.013178873,
-0.00044716452,
0.021497741,
0.009997533,
-0.0038243777,
0.0028648989,
-0.0024283107,
-0.036037143,
-0.008000733,
-0.037390906,
0.016082693,
0.00065826677,
-0.015987929,
0.025802704,
-0.005222137,
0.024354178,
-0.00802104,
-0.026777413,
-0.004602791,
0.018600691,
-0.0064777513,
-0.029593239,
-0.000030459645,
0.017301079,
-0.003008736,
0.016881412,
0.019264033,
-0.0045080273,
0.016570047,
0.011073774,
-0.015744252,
-0.015297511,
0.0049107717,
0.00072722405,
-0.034250177,
-0.005875327,
-0.008623464,
-0.026831564,
0.0007576837,
0.00007625487,
0.0050833765,
-0.046163283,
-0.002765059,
0.0030679633,
0.026926327,
-0.01433634,
-0.010078758,
0.011703272,
-0.0000954508,
0.009882463,
0.034060653,
-0.005672263,
0.030351344,
-0.028916357,
0.020238742,
-0.009523716,
0.028726831,
0.0025450727,
0.019264033,
0.028564379,
-0.02138944,
-0.0040477486,
-0.0054252013,
-0.003267643,
0.014187426,
-0.0123056965,
-0.009266501,
0.023135792,
0.009868925,
0.01735523,
0.023541922,
0.0113648325,
-0.0082241045,
-0.028429003,
0.008637002,
0.008230873,
-0.011215919,
0.012095864,
0.01870899,
-0.0063863723,
-0.008968674,
-0.0044403393,
-0.025207048,
-0.004328654,
-0.022066321,
0.010342742,
0.0027616746,
0.018627765,
-0.012759207,
-0.001654128,
-0.014309265,
-0.023948051,
0.056533102,
0.013706841,
0.0021287908,
-0.018560078,
0.009361264,
-0.015960854,
0.01616392,
0.011906337,
-0.014295727,
-0.005333822,
-0.015405812,
0.0028564378,
-0.0015162135,
0.008183491,
0.02629006,
0.022919191,
-0.00010502232,
0.037228454,
-0.013280406,
0.017788433,
-0.020171054,
0.007526917,
0.009137894,
-0.0076149115,
0.0063051465,
-0.024069889,
0.011913106,
-0.015175672,
-0.02428649,
0.009923075,
0.008528701,
-0.008048115,
0.011033161,
0.007838282,
-0.0075810673,
-0.0073509277,
-0.0060343943,
-0.02924126,
0.013578233,
0.003658542,
0.023420082,
-0.009266501,
-0.0045858687,
0.0008342558,
-0.03078455,
0.02224231,
-0.0066198963,
-0.019588936,
-0.032057084,
0.007181708,
-0.0077164434,
-0.008569313,
-0.005797486,
0.0022760124,
-0.035576865,
-0.01405205,
-0.046109136,
0.02576209,
-0.0029613543,
-0.01405205,
-0.0034554775,
0.030838698,
-0.015229823,
-0.00745246,
0.008156416,
-0.17144042,
0.019006819,
-0.007878895,
-0.01666481,
0.044674147,
0.0015686718,
0.02286504,
0.021145763,
0.011073774,
0.00733739,
0.01780197,
0.010613495,
-0.032977644,
-0.01849239,
-0.017395843,
0.0027549057,
-0.04164172,
0.0049683065,
0.0146477055,
0.0009865541,
0.03384405,
-0.019047432,
0.01746353,
-0.01991384,
0.005455661,
0.031488504,
0.008393325,
-0.009645554,
0.00688388,
-0.00881976,
-0.0153516615,
0.022066321,
0.039908905,
-0.013029959,
0.020523032,
-0.0008266409,
0.00372623,
-0.007594605,
0.0026212218,
0.0013977593,
0.027941648,
0.013957286,
-0.0049412316,
-0.031136526,
-0.03021597,
0.024597855,
0.0028953585,
0.0041898936,
0.021646654,
-0.02730538,
0.0121635515,
-0.020996848,
0.0041729715,
0.0282124,
0.021186376,
0.0023572382,
-0.015067372,
0.01763952,
-0.015026758,
0.010667644,
-0.017991498,
-0.0023775445,
0.025450727,
-0.02184972,
-0.001245461,
-0.04545933,
-0.019128658,
-0.01490492,
-0.02650666,
0.016515898,
-0.015053834,
-0.003993598,
-0.006826345,
-0.037445057,
0.0061020823,
0.0120687885,
-0.022634901,
0.0055538085,
-0.002247245,
-0.018600691,
-0.024137577,
0.023068106,
-0.029647388,
-0.015527651,
-0.01763952,
0.010633801,
0.0061866925,
-0.0027616746,
-0.01973785,
-0.0067891167,
0.027102316,
-0.019128658,
0.016285757,
-0.005046148,
0.027941648,
0.016976176,
-0.0010787791,
0.0039462163,
0.008549008,
-0.035360266,
0.04402434,
-0.027968723,
-0.022485986,
0.015852554,
0.018005036,
0.019534785,
-0.004044364,
0.00048439298,
0.032571513,
0.000041908454,
-0.0027785965,
-0.009381571,
0.008237642,
0.04608206,
-0.015947316,
0.029078808,
0.0030053516,
-0.013361631,
0.0023504694,
-0.020225205,
0.06378926,
0.0038717594,
0.002306472,
0.0152568985,
0.0033556377,
-0.038203165,
-0.13992484,
0.005963322,
-0.018979743,
0.02878098,
-0.011439289,
-0.002247245,
-0.00070818677,
0.013835448,
-0.0122109335,
0.01877668,
-0.020685485,
-0.023365933,
-0.006535286,
-0.013700072,
0.017152164,
0.0115069775,
0.01376776,
-0.010207365,
-0.017043864,
0.023460696,
0.0024080041,
0.0032659508,
0.022621363,
0.010606726,
0.010647338,
-0.025707942,
-0.031867556,
0.023866825,
0.005912556,
0.04215615,
0.022445375,
-0.0069447993,
0.010166753,
-0.0012767668,
-0.010234441,
0.008887447,
-0.008596389,
-0.018329937,
0.015162135,
0.0049006185,
-0.019480636,
-0.0078518195,
0.013564696,
-0.0054658144,
0.005272903,
-0.025491338,
0.007195245,
0.000025449139,
0.002891974,
-0.022431837,
-0.014999683,
-0.02258075,
-0.030595021,
-0.0209427,
0.01870899,
0.0052864407,
0.0032710275,
0.035685167,
-0.015067372,
-0.0057771793,
-0.0063897567,
-0.0035570096,
0.0034537853,
0.016542971,
0.025098749,
-0.018302863,
-0.007378003,
-0.020428268,
0.036714025,
-0.017152164,
-0.0013190719,
-0.00082325656,
-0.006491289,
-0.0015195978,
-0.016570047,
0.0070734066,
-0.031028226,
-0.01279982,
0.0006586898,
-0.01609623,
-0.00898898,
-0.020428268,
0.019196346,
0.0017886581,
0.01376776,
0.0024012353,
-0.006850036,
-0.023393007,
0.017477067,
-0.0042169685,
-0.016136844,
0.019440023,
0.0038785283,
-0.008291792,
-0.0120011,
0.0043455763,
-0.007858588,
-0.010627032,
0.019805538,
0.0030781163,
-0.022932729,
-0.022824427,
-0.07402371,
0.014146813,
0.026966939,
-0.002790442,
0.019494174,
0.009530485,
0.00028725137,
0.0029088962,
0.0141062,
-0.008014271,
-0.016637735,
-0.0061359266,
0.00248923,
-0.026696187,
-0.007161401,
-0.012962271,
0.038311467,
0.016394058,
0.019304646,
0.026141144,
-0.01650236,
-0.009489872,
0.021836182,
0.036199596,
-0.008576082,
0.013165336,
0.0040680547,
0.007919508,
-0.01154759,
0.01870899,
0.009950151,
-0.01433634,
0.0065860525,
-0.002130483,
-0.024015738,
-0.0051036826,
-0.029999366,
0.015798403,
0.015162135,
0.027657358,
-0.009076974,
-0.023988662,
0.022783814,
-0.013943749,
0.011615278,
0.0011887723,
-0.02730538,
0.030513797,
0.0052018305,
-0.0024096963,
0.0044911057,
0.021809107,
0.0008985595,
-0.019873226,
0.009449259,
0.007980427,
0.015107985,
-0.0101938285,
0.0044674147,
-0.040017206,
0.021064537,
0.01462063,
0.025694404,
0.01650236,
0.02497691,
-0.004755089,
-0.050359946,
-0.018140411,
0.020671947,
-0.049168635,
-0.010342742,
0.0009154816,
-0.0035028593,
0.008806222,
0.012021407,
0.0154464245,
-0.006792501,
0.009983995,
-0.0025941464,
0.02867268,
-0.0016287449,
-0.010918091,
-0.025355963,
0.002765059,
0.0335733,
-0.011831881,
0.007872126,
0.026086994,
-0.022905653,
0.011215919,
-0.0003526127,
0.021294676,
-0.012975809,
0.001956186,
-0.004426802,
0.04139804,
0.008413631,
-0.0056587253,
0.017125089,
0.021551892,
-0.01984615,
-0.0064879046,
-0.008488088,
-0.02069902,
-0.02275674,
0.01934526,
-0.018451776,
-0.06600944,
-0.021050999,
0.009828312,
0.00005052811,
-0.0036111602,
0.012441073,
0.0030815008,
-0.01666481,
0.0054421234,
-0.0042643505,
-0.013199179,
0.0032439523,
0.012779513,
0.013497007,
0.01774782,
0.011513746,
0.004352345,
0.008427168,
0.016299294,
0.033302546,
-0.0019477251,
0.00014690433,
-0.010593188,
-0.0005474275,
0.007520148,
-0.0096320165,
-0.024949834,
0.015013221,
0.018181024,
0.03554979,
0.013970824,
-0.024814459,
0.106730595,
0.010356279,
-0.012887814,
0.020671947,
0.0042846566,
0.022770278,
0.03054087,
0.021606041,
0.003140728,
-0.033925276,
0.0070869443,
-0.0073509277,
0.031407278,
-0.027034627,
-0.014458179,
0.020604258,
-0.008454244,
0.00051696785,
-0.0335733,
-0.03037842,
0.012508761,
-0.010403661,
0.005624881,
0.025545489,
-0.020495957,
0.0036450042,
0.031082377,
-0.002580609,
0.011608509,
-0.024448942,
-0.0047686268,
-0.016867874,
-0.040315032,
-0.020996848,
0.004805855,
-0.03132605,
-0.018844368,
-0.010708258,
0.03338377,
0.015459962,
0.025003985,
-0.0036416198,
-0.013970824,
-0.018763142,
-0.00035663167,
0.00847455,
-0.010748871,
-0.0010923167,
-0.02815825
] |
Allogeneic haematopoietic stem cell transplantation is used to treat a variety of disorders, but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past decade has brought impressive advances in our understanding of the role of stimulatory and suppressive elements of the adaptive and innate immune systems from both the donor and the host in GVHD pathogenesis. New insights from basic immunology, preclinical models and clinical studies have led to novel approaches for prevention and treatment. This Review highlights the recent advances in understanding the pathophysiology of GVHD and its treatment, with a focus on manipulations of | [
-0.0139544895,
-0.002716282,
0.023039307,
-0.028825315,
-0.013849765,
0.013293418,
-0.015158816,
-0.0013033245,
-0.017122393,
-0.018941976,
-0.003429715,
-0.010223692,
0.0039926074,
-0.0017770374,
0.00036183003,
-0.0022777496,
0.050660294,
-0.0053736563,
-0.027097367,
0.010852037,
-0.0386432,
0.018221997,
-0.00006642414,
-0.0127632525,
-0.009582257,
0.0077103134,
0.01701767,
-0.038486116,
0.002024121,
0.00069625175,
-0.003095907,
-0.013299963,
-0.008351749,
0.013175604,
-0.0010996033,
-0.008737919,
0.014412657,
-0.008724828,
0.016716588,
0.014019942,
0.013522502,
0.028327875,
-0.008305931,
-0.005625649,
0.020486657,
0.009955336,
-0.015865704,
-0.031364873,
-0.0074354126,
0.0075728633,
0.029087124,
0.00057393726,
-0.011519654,
0.015931157,
-0.018889613,
-0.011395293,
0.0061296336,
0.014870825,
0.01727948,
-0.023981825,
-0.018496897,
0.0030566354,
-0.008286296,
0.020277208,
-0.016939126,
0.018902704,
-0.01954414,
-0.008332113,
0.01675586,
0.0032202667,
0.025906129,
0.019033609,
-0.01282216,
-0.013640317,
0.015551532,
-0.008796826,
0.005193662,
-0.017947096,
-0.00033442175,
0.013561774,
0.019243058,
-0.039193,
-0.008397565,
0.02009394,
0.020774648,
0.01957032,
0.0064143525,
-0.0042216913,
-0.008083393,
-0.00902591,
0.008593923,
0.007978669,
0.016166786,
0.01652023,
-0.00042953252,
0.013097061,
0.019033609,
0.03935009,
0.016179876,
-0.019203786,
-0.0006667981,
-0.006600892,
0.00096787995,
-0.022541868,
-0.035370573,
0.01650714,
0.007965579,
0.013057789,
-0.008868824,
0.005376929,
-0.023039307,
0.040423512,
-0.0051412997,
-0.030631805,
0.020748466,
0.0009097908,
0.03785777,
0.012030183,
-0.010177876,
-0.00597582,
0.02869441,
-0.00025056064,
0.023994915,
-0.011598197,
0.015093364,
0.000468395,
-0.031914677,
0.00051134825,
-0.017541291,
-0.0070296065,
-0.006787432,
0.02108882,
-0.0061230883,
0.023536745,
-0.024348358,
0.012049819,
-0.015643166,
-0.006793977,
-0.016389325,
-0.022188423,
-0.009431716,
0.03099834,
0.012795978,
-0.0042282366,
0.0017606743,
0.020643743,
0.030134367,
-0.00060870894,
0.02669156,
0.012992336,
0.0020028488,
-0.028511142,
0.006276902,
0.0032709925,
0.013758131,
0.0073045073,
0.0037569779,
0.031914677,
-0.015878795,
-0.010498594,
-0.015564622,
-0.034689866,
0.015446808,
0.005069302,
0.006512531,
0.013535593,
-0.026887918,
0.007468139,
-0.012370537,
-0.034716047,
-0.010289145,
0.046471328,
-0.03230739,
0.008809917,
-0.012894157,
0.0068921563,
0.0036391632,
0.024806526,
-0.03756978,
-0.019661954,
-0.012481806,
-0.000609118,
0.016624954,
0.021206634,
-0.0013466867,
-0.0068790657,
0.019766677,
-0.01065568,
-0.00005461199,
-0.01679513,
-0.014190119,
0.021416083,
0.0064667147,
-0.0063587176,
-0.6350471,
-0.00648635,
0.005386747,
-0.0018195816,
0.032176487,
0.014412657,
0.023471294,
-0.02313094,
-0.009372809,
0.015486079,
-0.0021844797,
0.033956796,
0.009693527,
-0.029008582,
0.0033249909,
-0.030160546,
-0.013025062,
-0.04550263,
0.021756437,
-0.010197511,
0.0047093127,
0.0027800982,
-0.016821312,
0.010315326,
0.008161936,
-0.007919761,
0.0074026864,
-0.010478958,
-0.0018637622,
0.029663108,
-0.013371961,
0.029375115,
-0.008482654,
0.012854886,
0.05367111,
0.033459358,
-0.025186151,
0.027542444,
-0.0018097637,
0.018457627,
-0.00054611993,
-0.015603894,
0.014294842,
0.00038187488,
-0.013483231,
0.038695563,
0.014321024,
-0.008161936,
0.004872944,
-0.0026410115,
0.013064334,
0.013247602,
-0.009058637,
-0.0005011213,
0.01980595,
0.0007314325,
0.028537324,
-0.01700458,
0.023445113,
-0.0046307696,
0.019675044,
0.015904976,
0.005759827,
-0.01549917,
-0.0012632348,
-0.0078281285,
-0.027987521,
0.0073306886,
0.023680743,
0.005318022,
0.0067416155,
0.026455931,
-0.018915795,
0.0066074375,
0.025015974,
0.032543022,
-0.005370384,
-0.0020126668,
-0.011356022,
0.01258653,
-0.011146573,
0.004977668,
-0.001727948,
0.011853461,
0.043329604,
-0.025749043,
-0.02107573,
0.025801405,
-0.0038747925,
-0.0073110526,
0.001613406,
0.011048395,
-0.0060969074,
-0.058593147,
-0.024335267,
0.018326722,
0.000106360436,
0.0045718625,
0.010276054,
-0.011185845,
0.012599621,
0.00087461004,
0.012004002,
0.014177028,
0.0010464231,
0.023091668,
-0.0523097,
0.002971547,
0.032569204,
-0.031809952,
0.01396758,
-0.004463866,
0.0004090786,
0.0065354398,
0.01853617,
-0.012272358,
-0.005648557,
-0.0010685133,
0.001519318,
-0.031967036,
0.029636927,
-0.006011819,
0.007985215,
0.010413505,
0.019072881,
-0.011238207,
0.010819311,
-0.029034764,
-0.0018277632,
-0.0027915523,
0.008207753,
-0.021939704,
0.022816768,
-0.026757013,
0.029139487,
-0.015054093,
0.01068186,
0.0029273664,
-0.005880914,
-0.030108185,
-0.012076001,
-0.006250721,
0.0130708795,
0.013011972,
-0.027987521,
0.01167674,
-0.018392174,
-0.021939704,
0.015027911,
-0.026115578,
0.005648557,
-0.0076972228,
-0.0007101605,
0.005923458,
0.00628672,
-0.023301117,
0.028615866,
-0.031993218,
-0.0045620445,
-0.016677316,
-0.007625225,
0.030657986,
-0.0025166515,
0.022568049,
-0.02334039,
-0.009143725,
-0.014504291,
0.0154337175,
-0.008312477,
-0.026861737,
-0.0045162276,
-0.028772952,
-0.016101334,
0.0071277856,
-0.0014980459,
-0.019177604,
-0.005802371,
-0.008175027,
-0.008731374,
0.015944248,
-0.021494625,
-0.026835555,
-0.0076972228,
-0.01652023,
0.008371385,
-0.0030484537,
0.01522427,
0.0101124225,
0.013352325,
0.033145186,
-0.013234511,
0.013496321,
-0.023523657,
0.02086628,
-0.022646591,
-0.0076841325,
-0.0055307425,
0.008842643,
0.012023638,
0.030815072,
0.026050124,
-0.033119004,
0.016415507,
-0.0057630995,
0.016559502,
-0.016415507,
-0.010505139,
-0.0059038224,
0.015184998,
0.00018173316,
-0.0023792011,
-0.014962459,
0.004215146,
0.0022041155,
0.0005641194,
0.012357446,
-0.024505444,
0.015643166,
-0.016729679,
-0.006136179,
-0.024335267,
0.016873674,
0.022162242,
-0.012056365,
-0.012193815,
0.0074615935,
0.013548683,
-0.0005195298,
0.007599044,
-0.03610364,
-0.009241904,
0.009673891,
-0.008181572,
0.0020944825,
0.009320447,
0.0072325096,
-0.012180724,
0.0074288673,
0.041104216,
0.004771493,
-0.0028390056,
-0.005475108,
0.0026393752,
0.007009971,
0.0051183915,
-0.01065568,
0.01926924,
-0.015630076,
-0.033616442,
0.030055823,
-0.013509411,
-0.008823007,
0.00070770597,
-0.018078001,
0.0067547057,
-0.019151423,
0.013182148,
0.011375657,
0.033092823,
0.02515997,
0.012442535,
0.0005718919,
-0.028380238,
-0.026743922,
-0.0050725746,
0.018955067,
0.003923882,
-0.013862856,
-0.012645437,
0.017947096,
-0.017868552,
-0.0053114765,
0.025749043,
-0.027908979,
0.003040272,
0.018994337,
0.009582257,
0.008096484,
0.017423475,
0.004797674,
0.0015937702,
-0.03379971,
0.022777496,
0.022568049,
-0.010249874,
-0.0019897583,
-0.0014031396,
-0.0025166515,
-0.0075401366,
0.01625842,
0.013797403,
0.006181996,
0.000034055793,
-0.0031204515,
0.008404111,
-0.018169636,
0.02741154,
0.0062179947,
-0.00042748713,
-0.011342932,
-0.0064928955,
-0.01370577,
-0.048304003,
-0.018653983,
0.017646015,
0.010773494,
-0.011932004,
-0.014111576,
-0.011120393,
0.0015054093,
-0.016114425,
0.004355869,
-0.0053540207,
-0.035632383,
0.015891885,
0.01322142,
-0.012593076,
0.031076884,
0.02212297,
-0.0059267306,
-0.01678204,
-0.015577713,
0.0023252028,
-0.0087641,
0.04018788,
0.007546682,
-0.009680436,
0.025186151,
-0.0044475025,
0.0075728633,
0.011630923,
-0.021677893,
0.036051277,
-0.013509411,
-0.0042445995,
-0.0064568967,
0.013587954,
0.010210602,
-0.0026688287,
0.044612475,
0.00610018,
-0.006355445,
-0.0053834743,
0.005448927,
-0.004895853,
-0.005916913,
0.02285604,
0.024518535,
0.0238771,
-0.0014587743,
0.00927463,
-0.001988122,
-0.009307357,
0.007068878,
-0.012521078,
0.015656257,
0.018653983,
0.009333537,
-0.018379083,
-0.03225503,
0.013758131,
0.0012206906,
0.0075335917,
0.015054093,
0.021389902,
0.012219996,
0.009444807,
0.011349477,
0.021232815,
-0.01881107,
0.0058907317,
0.0010169694,
-0.02514688,
-0.012219996,
0.019229967,
-0.009510259,
-0.010145149,
-0.016834402,
0.018981246,
-0.003518076,
-0.020787738,
0.0012681436,
-0.014805373,
0.006031455,
-0.019151423,
-0.037465055,
0.003953336,
-0.0003033318,
-0.01879798,
0.0004377141,
-0.026966462,
-0.008521926,
-0.0051543904,
-0.009850613,
-0.014111576,
-0.005419473,
-0.009484078,
0.00004804117,
0.0037438874,
-0.0089604575,
0.020251026,
-0.00029965007,
-0.004116967,
0.010230238,
-0.017056942,
-0.003534439,
0.005000577,
-0.033249907,
0.024727983,
-0.00260174,
0.0032775376,
0.011886188,
-0.020067759,
0.02132445,
0.0031220878,
-0.01727948,
-0.016899856,
0.021978974,
-0.0006222085,
0.010917489,
0.033092823,
-0.00038678382,
-0.019688135,
-0.02515997,
-0.017724557,
-0.020486657,
-0.019897584,
-0.028249333,
0.0022630228,
-0.03374735,
-0.008521926,
-0.0013016881,
0.0001688472,
-0.031155426,
0.029532202,
-0.011342932,
-0.0040842406,
-0.0130512435,
0.014412657,
0.0018195816,
0.010838946,
0.011120393,
0.015276631,
-0.003590074,
-0.02053902,
-0.010740768,
0.022541868,
0.01040696,
-0.02769953,
-0.0014890461,
0.0021108456,
-0.017999459,
-0.023065487,
-0.0068725203,
-0.0018261268,
0.03503022,
-0.0013589591,
-0.0014694104,
-0.024492353,
-0.009575712,
-0.0017508564,
0.016494049,
0.017449657,
-0.040318787,
-0.005239479,
-0.004418049,
0.005059484,
-0.013005427,
0.009647709,
-0.036443993,
-0.017070033,
0.021769527,
0.019858312,
-0.014046123,
-0.006250721,
-0.01334578,
-0.012468716,
0.013443959,
-0.023000035,
-0.03887883,
-0.003341354,
-0.009065182,
0.04270126,
0.033380814,
0.030212909,
-0.02131136,
0.004224964,
0.039690442,
0.00054530177,
0.003518076,
-0.02053902,
0.018208906,
-0.014150847,
0.0027637351,
0.00939899,
0.008698647,
0.0037046159,
-0.0013597773,
0.03356408,
0.009922611,
-0.0066434364,
-0.040711503,
-0.016991489,
-0.04021406,
-0.03455896,
0.009097908,
0.0008975185,
-0.016166786,
-0.03458514,
0.0007531137,
0.006604165,
0.010622953,
0.0067481603,
0.005386747,
0.024269816,
0.007317598,
-0.0028030067,
0.003086089,
0.0022253876,
-0.00800485,
-0.007212874,
-0.0073568695,
-0.014687558,
0.022960763,
0.004980941,
0.0026770104,
0.011748738,
-0.02461017,
0.00673507,
0.009628074,
-0.046157155,
-0.0016633136,
-0.0129727,
-0.038774107,
-0.006073999,
0.0021010276,
-0.01625842,
-0.031809952,
-0.007009971,
0.012691255,
-0.014805373,
0.004771493,
-0.019976126,
-0.008600469,
0.01679513,
-0.0077561303,
-0.0032513568,
-0.017344933,
0.023759285,
0.02412582,
-0.017135484,
-0.038041037,
-0.004044969,
-0.0046176794,
0.0066401637,
0.0061492696,
0.008332113,
0.001763947,
-0.033459358,
0.031364873,
0.017397294,
-0.0036817074,
-0.036627263,
0.0127828885,
0.036758166,
0.0048467633,
-0.012435989,
-0.027594807,
-0.010832401,
0.03246448,
0.014792282,
0.018365992,
0.0061034528,
-0.012874521,
-0.012619257,
0.0030615442,
-0.0071212403,
-0.0033429903,
-0.0005903004,
-0.012108726,
-0.009235359,
-0.039454814,
-0.004715858,
0.013993761,
-0.012377082,
0.034480415,
-0.009601893,
0.007900126,
0.028144607,
-0.0005003031,
0.016991489,
-0.020447385,
-0.010027335,
0.040528234,
-0.0021435719,
-0.009045546,
0.02720209,
0.025120698,
-0.012134908,
-0.015616985,
-0.016860584,
0.004620952,
-0.026678469,
-0.0028390056,
0.013574864,
0.031391054,
-0.010852037,
0.021167364,
-0.025303965,
-0.027306814,
-0.027463902,
-0.028223151,
0.031809952,
-0.025906129,
-0.0047387667,
-0.0024806526,
0.005570014,
0.017096212,
0.0047682202,
-0.0072783264,
0.018575441,
0.021978974,
-0.019923763,
0.019740498,
0.035239667,
0.03044854,
-0.016899856,
0.011185845,
-0.0193216,
-0.030631805,
0.010590226,
-0.004169329,
-0.02489816,
-0.02417818,
-0.0021795707,
0.0050823926,
-0.006885611,
-0.0019963037,
-0.0035311666,
-0.0016886764,
0.02564432,
-0.007998304,
-0.007350324,
0.01980595,
-0.004964578,
-0.010256419,
0.011892733,
-0.0075335917,
0.026796285,
0.01079313,
0.005547106,
-0.0027964613,
-0.024295997,
-0.014517382,
-0.0067416155,
0.009287721,
-0.01905979,
-0.0003315582,
-0.00890155,
-0.00749432,
-0.011788009,
0.010184421,
0.017737648,
-0.019989217,
0.0008787008,
-0.015852613,
-0.003783159,
0.014582834,
-0.0061950865,
0.029034764,
0.00024115184,
-0.015590804,
-0.041496933,
0.0043002344,
-0.006620528,
0.039166823,
0.0015005002,
0.012030183,
-0.0078281285,
0.018667074,
-0.065086044,
0.0000776738,
0.027254453,
0.012370537,
0.009307357,
0.030369995,
-0.0025330146,
-0.0026901008,
-0.013875946,
0.024754165,
0.015355174,
0.0025248332,
0.018876523,
0.006319446,
0.019661954,
0.017096212,
-0.05105301,
-0.0073568695,
0.012416353,
0.014321024,
0.024086548,
0.012737071,
0.014700648,
0.030657986,
-0.00801794,
0.0066630724,
0.003596619,
-0.0027440994,
-0.0042347815,
-0.014203209,
-0.027568625,
0.013784313,
-0.0101713305,
-0.017632924,
0.002868459,
0.012357446,
0.00085333793,
-0.0037766136,
-0.015708618,
-0.021193543,
0.012599621,
-0.017371114,
-0.010989487,
0.0157348,
-0.010086242,
0.0130708795,
0.010027335,
0.0057009193,
-0.00811612,
0.015564622,
-0.0013835038,
-0.009778615,
-0.0017884916,
-0.0068659754,
-0.015708618,
0.0076317703,
0.011002578,
-0.021978974,
-0.014674468,
-0.016912946,
-0.0008181572,
-0.022266967,
0.029820194,
0.004784583,
-0.008744464,
0.008443383,
0.019897584,
-0.008849189,
-0.016638044,
-0.01195164,
0.007815038,
-0.018025639,
-0.004647133,
-0.019753587,
-0.013182148,
-0.0046045887,
0.015904976,
-0.01497555,
-0.041235123,
0.014713739,
0.19227348,
-0.030788891,
0.016454777,
-0.017475838,
-0.008312477,
-0.03738651,
0.029060943,
-0.004555499,
-0.009235359,
0.014307933,
0.0305009,
-0.007239055,
-0.0049416693,
0.0016436778,
0.00050766655,
-0.031207789,
-0.036470175,
-0.012468716,
-0.008823007,
-0.016899856,
0.0031466326,
0.0098047955,
0.012141453,
-0.021651711,
0.027882798,
0.008384475,
0.00520348,
0.031103063,
0.020709194,
0.012874521,
-0.011166209,
-0.008895005,
0.015656257,
0.0025821042,
0.013247602,
0.00413333,
-0.010262964,
-0.023091668,
-0.0008357476,
0.0115916515,
-0.006852885,
0.024348358,
-0.026063215,
0.008456473,
0.005239479,
0.022005156,
-0.00020545973,
-0.0076841325,
-0.0072979624,
-0.018928885,
-0.035187304,
-0.0075401366,
-0.0010120604,
0.018968156,
-0.0016183149,
0.012219996,
0.030684168,
0.015852613,
0.0007510683,
0.006568166,
0.0053540207,
0.0032742652,
-0.035972737,
0.042099096,
0.013110151,
0.02974165,
-0.02796134,
-0.010465867,
0.0060609085,
0.0066696173,
-0.0051707537,
-0.0050823926,
-0.018732527,
-0.003164632,
-0.0021533899,
-0.0035409844,
0.016075153,
0.015682437,
0.0015954066,
0.011336386,
-0.007860854,
0.00850229,
-0.028877677,
0.009444807,
0.011159664,
-0.034611322,
0.016101334,
0.0038584294,
-0.027568625,
0.0021043003,
0.013404688,
0.017672196,
-0.021389902,
-0.010256419,
0.001727948,
0.0013671407,
0.01068186,
0.013038153,
0.010341507,
-0.0040253336,
-0.036443993,
0.084774174,
-0.0025788315,
0.010786585,
-0.015983518,
0.034454238,
0.0072979624,
0.0015291359,
-0.023458203,
0.016480958,
0.01283525,
-0.02412582,
0.003544257,
-0.014543562,
0.007114695,
0.028301693,
0.0109960325,
-0.024034185,
0.034506597,
0.013162513,
0.0047125854,
-0.01854926,
0.0036162548,
0.040685322,
-0.00019144878,
0.0033315362,
-0.023274936,
0.017488929,
-0.020381931,
-0.02793516,
-0.013614136,
0.0021730256,
0.0028308239,
0.014451928,
0.0078281285,
-0.016559502,
0.012350901,
-0.005648557,
-0.034689866,
0.015525351,
-0.011670195,
-0.0041856924,
0.0256705,
0.022712044,
0.030474719,
-0.021468446,
0.008220844,
-0.0028422782,
-0.019976126,
-0.031548142,
-0.015603894,
-0.01043314,
-0.0067219795,
-0.0036653443,
0.009196087,
-0.024871979,
-0.018732527,
-0.023602199,
0.03306664,
0.01168983,
-0.027175909,
0.024099639,
0.011539289,
-0.013430868,
-0.010393869,
-0.023785466,
-0.16305545,
-0.0031269968,
0.014190119,
-0.014033033,
0.028039884,
-0.0049023977,
0.007042697,
0.015315902,
-0.02416509,
0.007723404,
0.040004615,
0.014059213,
-0.017606743,
-0.02924421,
0.0008292023,
-0.007291417,
-0.016153695,
0.045607354,
0.020028489,
-0.0006569802,
-0.0072456,
-0.006188541,
-0.0019570321,
-0.028380238,
0.0012403263,
-0.016467867,
0.02666538,
0.0016142242,
-0.011630923,
-0.012010547,
-0.01271089,
-0.0005526652,
0.009654255,
0.006021637,
-0.020892462,
-0.013306509,
0.022725135,
0.0010210602,
0.016912946,
0.029348936,
0.030082004,
0.0037929767,
-0.010105878,
0.00888846,
-0.02059138,
0.03963808,
-0.007114695,
-0.020133212,
0.03584183,
0.0095560765,
0.020264117,
0.013666498,
-0.012049819,
0.024544716,
-0.0016518594,
0.009700072,
0.0145304715,
0.008803371,
-0.0023890191,
0.003215358,
0.0028128244,
-0.028668229,
0.008770646,
-0.002102664,
0.0026410115,
-0.013201784,
-0.0023088397,
0.019360872,
-0.015839523,
-0.0065027135,
-0.0365749,
0.0064568967,
0.014857735,
-0.008580833,
0.03940245,
0.017423475,
-0.0144912,
0.005828552,
-0.004611134,
0.001108603,
-0.011009123,
0.0024708346,
-0.014033033,
-0.017907824,
0.0060412725,
0.013293418,
0.012488351,
-0.0033184455,
0.005131482,
-0.010478958,
0.031443417,
-0.028484961,
0.01257344,
-0.012403263,
0.0037013432,
0.020447385,
-0.0062736296,
-0.013862856,
0.019439414,
0.0074615935,
0.027018823,
-0.010989487,
-0.002821006,
-0.015878795,
0.01602279,
-0.0034395328,
-0.004238054,
0.0019815767,
0.04495283,
-0.002997728,
-0.020224845,
0.022214605,
-0.001988122,
0.025081428,
0.0047649476,
0.018143455,
0.01002079,
-0.0126978,
-0.018981246,
-0.03152196,
0.059012044,
0.022450233,
-0.027987521,
0.010590226,
-0.0026917371,
-0.0153944455,
-0.13540828,
-0.010236783,
0.014766101,
-0.032726288,
-0.005648557,
0.012507987,
-0.003861702,
-0.0036031643,
-0.022685863,
0.008613559,
-0.046209518,
-0.03356408,
-0.020617561,
-0.008240479,
0.04089477,
0.000110348956,
-0.014006851,
-0.027175909,
-0.013443959,
0.03683671,
-0.0049023977,
-0.008292842,
-0.012383628,
-0.01447811,
-0.0066892533,
0.024767255,
-0.017331842,
0.03756978,
0.015525351,
0.025264693,
0.024701802,
-0.004820582,
0.026220301,
-0.006293265,
-0.015826432,
-0.016926035,
-0.024282906,
-0.02082701,
0.012848341,
-0.021245906,
-0.015800253,
0.016140604,
0.0063423547,
-0.0022499324,
0.019491777,
-0.020787738,
-0.016808221,
0.0007252964,
0.028825315,
-0.009294266,
-0.0314696,
-0.043853227,
-0.042517994,
-0.004997304,
0.006080544,
0.016690407,
-0.00033973978,
0.009758979,
-0.026272664,
0.017227119,
0.0023857465,
0.002436472,
-0.015512261,
-0.009961882,
0.016310781,
-0.026364297,
-0.016611863,
-0.022424053,
0.02564432,
-0.030134367,
-0.019609591,
-0.00028369602,
-0.0145304715,
-0.016546411,
-0.009032455,
0.021167364,
-0.009883339,
-0.020840101,
0.008155391,
-0.004310052,
-0.023196394,
-0.008469563,
0.02540869,
-0.019387053,
0.045633536,
0.0106687695,
0.0052787503,
-0.007441958,
0.010845492,
-0.004463866,
-0.026455931,
0.014294842,
-0.01371886,
0.005102028,
0.0075074104,
-0.005239479,
0.0037406147,
-0.004987486,
0.012966155,
0.03482077,
-0.006453624,
0.0037275243,
-0.048146915,
0.009431716,
-0.0016477685,
0.009353173,
-0.0058678235,
-0.021402992,
0.010976397,
-0.010714587,
0.017659105,
-0.0061034528,
-0.028799133,
-0.005746736,
-0.018509988,
0.026887918,
-0.026992641,
-0.02009394,
0.025199242,
-0.014294842,
0.0051183915,
0.030893616,
-0.019452505,
-0.029008582,
0.009817886,
0.03044854,
0.019622682,
-0.0015381356,
-0.0072521456,
0.024531625,
0.0013082334,
-0.02313094,
0.020198666,
-0.0314696,
-0.026586836,
-0.0065354398,
-0.014504291,
-0.039009735,
0.023314208,
0.01750202,
0.022829859,
0.056551024,
-0.016284602,
-0.020355752,
0.016415507,
-0.00043321424,
-0.009019365,
0.010917489,
-0.031312514,
0.030082004,
0.0024004732,
-0.019125242,
0.044115037,
0.0027522808,
0.0056027407,
-0.031443417,
-0.0033086278,
0.022044428,
0.013797403,
-0.010982942,
-0.0049023977,
-0.006587802,
0.0077626756,
-0.0015217724,
-0.0037046159,
-0.0036195274,
-0.0069772447,
-0.030762712,
-0.028380238,
-0.004673314,
0.011133484,
0.008489199,
-0.032097943,
0.006839794,
-0.009830977,
0.012318174,
0.014059213,
0.011578561,
0.021180453,
0.005131482,
-0.015041002,
-0.0032677199,
0.0094971685,
-0.012992336,
0.0009007911,
0.027228272,
0.011441111,
0.009503714,
-0.021834979,
0.032124124,
0.0034428055,
-0.0064699873,
-0.0021926614,
0.018104183,
0.0034886224,
0.02010703,
0.024597079,
0.046916407,
0.0009826068,
-0.00068316126,
0.023104759,
0.03277865,
0.0036097097,
0.008096484,
0.02131136,
-0.0076972228,
-0.015708618,
0.023471294,
-0.03220267,
-0.030815072,
-0.017488929,
-0.007671042,
0.015119545,
0.0094971685,
0.003920609,
0.0002331748,
-0.030762712,
0.012704345,
0.0063358094,
-0.020617561,
-0.008089938,
0.040580597,
0.013823584,
0.008188117,
-0.0038289756,
-0.015957339,
0.017881643,
-0.004476956,
0.013548683,
-0.024492353,
0.023183303,
0.008895005,
0.010380778,
-0.01244908,
-0.027359176,
-0.01597043,
-0.00083370216,
-0.027725711,
0.014294842,
0.016101334,
-0.0024659259,
0.04848727,
0.018968156,
-0.0045358636,
0.005943094,
-0.019400144,
-0.0013646862,
-0.0038747925,
0.025277784,
-0.009117544,
-0.03403534,
0.03379971,
-0.0035540748,
0.007500865,
-0.024152001,
-0.018627804,
0.025997763,
-0.016494049,
0.012547259,
-0.016415507,
0.006787432,
0.019125242,
0.001806491,
0.008057212,
0.0014080486,
-0.024714893,
-0.008823007,
-0.005059484,
-0.031155426,
0.007363415,
-0.017541291,
-0.0007089332,
0.017947096,
-0.04822546,
-0.011585106,
-0.014294842,
0.010210602,
-0.024453083,
-0.0133588705,
0.0074288673,
0.0010979669,
0.0050562113,
0.050005767,
-0.008914641,
-0.018261269,
-0.012514533,
-0.024701802,
-0.043931767,
-0.0017541291,
0.006303083
] |
RATIONALE Idiopathic pulmonary fibrosis (IPF) is a devastating disease. Antiinflammatory therapies, including corticosteroids, are of no benefit. The role of monocytes and macrophages is therefore controversial. OBJECTIVES To define the role of monocytes and macrophages during lung fibrogenesis and resolution, and explore the phenotype of the cells involved. METHODS We used multiple in vivo depletional strategies, backed up by adoptive transfer techniques. Further studies were performed on samples from patients with IPF. MEASUREMENTS AND MAIN RESULTS Depletion of lung macrophages during fibrogenesis reduced pulmonary fib | [
-0.037765045,
0.004880539,
-0.0066028866,
-0.04560056,
-0.028810173,
0.006269744,
-0.03403385,
0.017190158,
-0.016177405,
-0.008461822,
0.0156044,
-0.014418412,
0.035819493,
0.017416695,
-0.01861601,
-0.005800013,
0.034140453,
0.0021321126,
-0.015497794,
-0.0062897326,
-0.018762592,
0.03158192,
-0.0023936296,
-0.019402226,
-0.0008374372,
0.01997523,
0.02714446,
-0.038084865,
-0.016257359,
-0.02214732,
0.0085684275,
-0.013818756,
-0.0021321126,
0.0075156973,
0.0040077055,
-0.008288588,
0.008668371,
0.0058466527,
0.010620587,
-0.0071892175,
0.023799708,
-0.004254231,
-0.013132482,
0.01532456,
0.0054901903,
-0.00607319,
0.005207019,
-0.02146771,
-0.018456101,
0.0037545173,
0.034193758,
-0.013765452,
0.01247286,
0.0040143686,
-0.007249183,
-0.00964781,
-0.016643805,
0.027037853,
0.0040210313,
-0.024172828,
-0.0149114635,
-0.010334084,
-0.012299625,
-0.0019888615,
-0.013565567,
0.015990846,
-0.010147524,
0.023413263,
-0.008921559,
0.004504088,
0.05221011,
0.029050035,
-0.008375205,
-0.0057034013,
0.015191303,
-0.018136283,
0.0033297604,
0.005753373,
-0.0043741623,
0.007255846,
0.026624758,
-0.0070492974,
-0.015644377,
0.017270112,
0.024679204,
-0.0020471613,
0.0048305676,
0.0149114635,
0.007855503,
-0.016150754,
0.004863882,
0.03803156,
0.01997523,
0.015164652,
-0.010100884,
0.012706059,
-0.0014766547,
0.015977519,
0.01310583,
-0.02186748,
-0.016990272,
0.014098595,
-0.017856443,
-0.016737085,
-0.03672564,
0.018655986,
-0.0026151694,
-0.0046939794,
0.039470736,
-0.008728337,
-0.013065853,
0.0435484,
-0.004604031,
-0.03720537,
-0.0015999174,
-0.01214638,
0.0042442367,
0.01116694,
0.0052836416,
0.0067927777,
0.010740518,
0.026424872,
0.025412118,
-0.0022220612,
0.020641517,
-0.012979236,
-0.042135876,
-0.017923072,
-0.030702423,
0.013305716,
0.014218527,
0.024732508,
0.03973725,
-0.008475148,
-0.019308945,
-0.010500655,
-0.04098987,
-0.020348351,
-0.03803156,
-0.026904598,
-0.014964766,
0.03331426,
-0.013765452,
-0.009987615,
-0.0056700874,
0.013792104,
0.02912999,
0.0063230465,
0.011000369,
-0.0036212602,
-0.009268028,
-0.031182148,
-0.0033297604,
-0.012539488,
0.0024069555,
-0.00371454,
-0.008888245,
0.024106199,
-0.0046406765,
0.0046140254,
0.001155172,
-0.019895276,
0.011766597,
0.021067938,
0.034913346,
0.005127065,
0.017736513,
0.013192447,
-0.0027600864,
0.015271258,
0.007222532,
0.024705855,
-0.0118199,
0.029529762,
0.012646093,
0.014498366,
0.015084697,
0.0055235047,
0.0017506644,
-0.030116092,
-0.015217954,
0.0122329965,
-0.0057034013,
-0.020361677,
-0.008748325,
-0.001439176,
0.045920376,
-0.015297908,
-0.00537359,
-0.031741828,
0.0027434293,
0.029636366,
-0.003314769,
-0.029289898,
-0.61788625,
-0.024452668,
0.031501964,
0.0015924217,
0.0049938075,
0.01836282,
0.011673317,
-0.025851866,
-0.009048154,
0.028490355,
-0.006153144,
0.019348923,
0.018016351,
-0.008268599,
-0.012992562,
-0.029742973,
-0.026451522,
-0.007115926,
-0.025305513,
-0.019375574,
-0.009427936,
0.0054602074,
0.011859877,
0.028330447,
-0.018229563,
0.01836282,
0.043281887,
0.001683203,
0.007249183,
0.0435484,
-0.017176833,
0.011659991,
-0.009614496,
-0.01926897,
0.052503277,
0.008235285,
-0.018429449,
0.031875085,
0.027251065,
0.008335228,
-0.0032048319,
0.0015799288,
0.0207881,
-0.028063934,
-0.0052669845,
0.040776655,
-0.011053672,
0.018469427,
0.010154187,
0.0075556743,
-0.006139818,
0.02121452,
-0.024439342,
0.011193592,
0.03139536,
0.008848268,
0.013418985,
-0.0149114635,
0.006333041,
-0.0012626105,
-0.001061892,
0.013325704,
-0.014658275,
-0.020774772,
0.005426893,
0.00021081681,
-0.008062051,
-0.008521788,
0.0028666921,
0.005290305,
0.022720326,
0.041922666,
-0.010134198,
0.0073824404,
0.019588785,
0.01997523,
-0.011220243,
0.0042175855,
-0.015217954,
0.0207881,
0.008808291,
0.0037178716,
-0.0010768835,
0.020175116,
0.027664162,
0.0065329266,
-0.0130791785,
0.0029333206,
-0.0049271793,
0.0035146545,
0.0035246487,
0.00005762326,
-0.0044774367,
-0.02745095,
-0.008328565,
0.033634078,
-0.014485041,
-0.010833798,
0.0063297097,
-0.00021071271,
-0.028463705,
-0.007675606,
-0.00387778,
0.007815526,
0.04538735,
0.011606689,
-0.030196046,
-0.0021620956,
0.04240239,
-0.03992381,
0.017016925,
-0.02081475,
0.004650671,
-0.027277717,
0.014964766,
-0.018229563,
0.015138,
-0.020948008,
0.011613351,
-0.029929532,
0.011833225,
-0.00978773,
0.023013491,
0.01485816,
-0.0010260793,
0.018109633,
-0.0058066756,
-0.023866337,
-0.023399936,
-0.010853786,
-0.0103807235,
-0.0043908195,
0.029423155,
-0.004144294,
0.03557963,
0.00581667,
0.033340912,
0.003627923,
0.0025218895,
-0.036379173,
-0.027291043,
-0.013005887,
0.012279636,
-0.0035679573,
-0.0036412487,
-0.014458389,
-0.004574048,
-0.001021915,
0.014205201,
0.030995589,
0.008315239,
0.004011037,
0.008921559,
0.031715177,
0.02333331,
-0.013272402,
0.008461822,
-0.031715177,
-0.020281723,
-0.016896993,
-0.005253659,
-0.020668168,
0.009541204,
0.014031967,
-0.011533397,
-0.021521013,
-0.009228051,
0.009141433,
-0.013438973,
-0.018096307,
-0.013032539,
-0.0044774367,
-0.03008944,
0.004097654,
-0.011946494,
0.012432883,
-0.006293064,
-0.033927243,
-0.0026085067,
-0.011786586,
0.0007354123,
-0.02593182,
0.018296191,
0.010827134,
0.0023986269,
0.022280578,
0.026091728,
0.0004963825,
-0.012026448,
0.05237002,
-0.015351212,
0.012712722,
-0.014938114,
0.025145603,
0.012492848,
-0.011613351,
0.0011876534,
-0.0033863946,
-0.0041742767,
0.022707,
-0.0047872593,
-0.037178714,
0.016483895,
-0.024705855,
0.019562135,
-0.023479892,
-0.003083235,
-0.010434027,
0.023066794,
-0.007069286,
-0.007875491,
0.017336741,
-0.009827707,
-0.009001513,
-0.00752236,
0.025145603,
0.017643232,
-0.015177977,
-0.00927469,
-0.012079751,
-0.010507318,
0.009947638,
0.02240051,
0.0056334417,
-0.0340605,
0.014938114,
0.009881009,
0.022826932,
0.0146716,
-0.0139653385,
-0.0121330535,
-0.0059232754,
0.012179694,
0.00027879872,
-0.015750982,
0.01731009,
-0.00020290467,
-0.019189015,
0.04973153,
0.006729481,
0.023240028,
0.014165224,
0.02116122,
0.0010935406,
-0.033260956,
0.0039144256,
0.0170036,
0.004923848,
-0.00094779074,
0.027037853,
0.00041913503,
0.022453811,
-0.005410236,
-0.026824642,
-0.0032548034,
-0.0121330535,
0.013392333,
0.020108487,
0.030435909,
0.0148315085,
0.011200255,
-0.015111349,
0.011080323,
-0.021827504,
0.0041476255,
0.0011460106,
0.0059132813,
-0.021987412,
-0.018482752,
-0.0058433213,
-0.048718777,
0.011373488,
0.025092302,
-0.028090585,
0.023120098,
0.0022370527,
0.02875687,
0.006566241,
0.019095734,
0.0029216607,
-0.0041342997,
-0.011066997,
0.026398221,
0.013778779,
-0.0056234472,
-0.01703025,
-0.022160646,
0.0058466527,
-0.013265738,
0.017949725,
0.017083554,
0.0038111515,
0.012539488,
0.0057733613,
-0.0069426917,
-0.0037378601,
0.019495506,
-0.003001615,
-0.00035646258,
0.0016099117,
-0.0074557317,
-0.0062164413,
-0.0067094923,
-0.019468853,
0.031901736,
0.00885493,
-0.0012601119,
-0.008914896,
-0.004880539,
-0.008661708,
0.007888817,
-0.0113468375,
0.0059998985,
0.00058424886,
-0.013912035,
-0.006802772,
-0.020574888,
0.015031395,
0.05959255,
-0.007529023,
0.014111921,
-0.02252044,
0.015591074,
-0.008002086,
0.016963622,
0.020241745,
-0.009674462,
0.0038111515,
0.011153614,
0.015084697,
0.016217383,
-0.03142201,
0.023546519,
-0.025012348,
0.021054612,
-0.010027593,
0.008774976,
0.015497794,
0.0007587323,
0.020761447,
-0.0076422915,
-0.018749267,
-0.007882155,
-0.008695022,
-0.008428508,
0.017976375,
0.029423155,
0.016670456,
0.0052170134,
-0.0023003498,
-0.0012359591,
-0.0024985697,
-0.007349126,
-0.015204629,
-0.028490355,
0.0014100261,
0.009541204,
0.0031665205,
-0.018762592,
-0.015910892,
0.011100312,
-0.015577748,
0.013172459,
0.016204057,
-0.01770986,
0.006976006,
0.01740337,
0.013052528,
0.017603256,
0.0072425203,
-0.014644949,
0.011773259,
0.011859877,
-0.004454117,
0.023786383,
-0.035526328,
-0.018509403,
-0.024439342,
0.029609716,
-0.0093946215,
0.0030082779,
-0.008435171,
0.0138454065,
-0.0041476255,
-0.015897565,
-0.03589945,
0.0010785492,
-0.011200255,
-0.011100312,
-0.033047747,
0.003517986,
-0.014818183,
-0.026971227,
0.003837803,
0.011100312,
-0.023746405,
0.00371454,
0.033047747,
-0.0032864518,
0.023040144,
0.02478581,
-0.0032015005,
0.0057267216,
0.008135343,
-0.005433556,
-0.0071359146,
-0.0021287813,
-0.042055923,
0.004194265,
0.002275364,
0.012732711,
-0.00040185326,
-0.02326668,
0.019415552,
0.026811317,
-0.019255644,
-0.0032814548,
0.01765656,
-0.017056901,
-0.012632768,
0.0122329965,
0.0025318838,
-0.009634485,
-0.033634078,
-0.0064229895,
-0.025198907,
-0.015151326,
-0.018855872,
-0.0020671498,
-0.01011421,
0.006676178,
-0.013991989,
-0.008981525,
-0.0062164413,
0.018216237,
0.0033597432,
0.005926607,
0.0038111515,
0.016737085,
0.010753843,
-0.019801997,
0.009214724,
0.01948218,
-0.0055001844,
0.010980381,
-0.001265109,
0.032594673,
0.008768314,
-0.025358815,
-0.018909175,
-0.004823905,
-0.025691958,
-0.019415552,
-0.023213377,
-0.044401247,
0.033953894,
0.013072516,
-0.03459353,
-0.029050035,
0.0075023714,
-0.0050137965,
0.009188073,
-0.005143722,
-0.02338661,
-0.00537359,
-0.016084125,
-0.01074718,
0.020828076,
0.027744116,
-0.0349933,
-0.004580711,
0.03350082,
-0.011973145,
0.015444491,
-0.03955069,
0.0053969105,
0.009914324,
0.014591646,
-0.028490355,
-0.029663017,
0.001096872,
-0.030142743,
0.049624924,
0.038724497,
0.004877208,
-0.014285155,
0.025545375,
-0.0138454065,
-0.00037790864,
-0.010020929,
-0.001463329,
0.007575663,
-0.028490355,
0.030809028,
0.04424134,
0.0008499301,
0.01277935,
-0.045120835,
-0.006692835,
0.009341319,
-0.018216237,
-0.01523128,
-0.01025413,
-0.014631623,
-0.03744523,
0.019588785,
-0.0016257359,
-0.010640575,
-0.032461416,
-0.007222532,
0.012832654,
-0.005783356,
0.014111921,
0.008768314,
0.016497223,
-0.027264392,
0.01854938,
-0.013565567,
-0.005450213,
-0.003604603,
0.0015274589,
0.00042371577,
0.0054202303,
0.004760608,
0.009581181,
-0.004863882,
-0.0058366586,
-0.016590502,
0.02240051,
-0.00036916367,
-0.014378435,
-0.018536055,
-0.026758015,
-0.03160857,
-0.00000692312,
-0.005253659,
-0.0046873167,
-0.026797991,
0.018669311,
0.009960964,
-0.01684369,
0.0050404477,
-0.013832081,
-0.038884405,
0.019615436,
-0.006772789,
0.002322004,
-0.01824289,
0.024212806,
0.038298074,
-0.031821784,
-0.01864266,
-0.010334084,
0.00059632526,
-0.0007154237,
0.04408143,
0.01994858,
-0.025332164,
-0.017083554,
-0.007082612,
0.008068714,
-0.0075023714,
-0.017509976,
0.014445064,
0.020055186,
0.0047739334,
0.0015749317,
0.0006804438,
-0.04352175,
0.00766228,
-0.031102194,
0.0024102868,
-0.010420701,
-0.022160646,
-0.01504472,
-0.0049604937,
0.003349749,
0.008968199,
0.007435743,
-0.028250493,
-0.012899281,
-0.008381868,
-0.013239088,
0.026251638,
-0.0005234503,
0.026997877,
0.0067061605,
0.008408519,
-0.0063930065,
0.0064363154,
-0.01126022,
0.009161422,
-0.014938114,
0.044747714,
0.002618501,
0.017736513,
-0.008015411,
0.00904149,
0.0071758917,
-0.044614457,
0.0028317121,
-0.025665307,
0.0057733613,
0.014551669,
0.03536642,
0.000815783,
-0.03667234,
0.015124675,
-0.017536627,
-0.008481811,
0.0063696867,
-0.016670456,
0.0073291375,
-0.020108487,
0.003957734,
-0.0007162566,
0.015910892,
0.02333331,
0.00913477,
-0.012372917,
-0.020641517,
0.010414038,
-0.01743002,
0.014485041,
-0.0059998985,
-0.004011037,
-0.01770986,
-0.00983437,
-0.030355955,
-0.041736107,
-0.008761651,
-0.014378435,
-0.030915635,
0.0009861022,
0.0037311972,
0.005346939,
-0.003303109,
-0.023799708,
0.02705118,
0.015284583,
0.010667226,
-0.014191875,
0.003791163,
0.036059357,
-0.0015999174,
-0.014618298,
0.0093946215,
-0.00054135674,
-0.00752236,
0.009940975,
-0.0008403522,
0.016457245,
-0.01805633,
-0.021361103,
-0.0075556743,
0.013112493,
-0.059539247,
-0.005580139,
0.006522932,
-0.021547664,
-0.0005900788,
0.0070093204,
0.007862166,
-0.0084884735,
-0.01315247,
0.007155903,
-0.0034047174,
-0.008555102,
-0.027770767,
0.007902143,
0.0105406325,
-0.017110204,
-0.010507318,
0.003408049,
-0.036245916,
0.0737711,
-0.009807718,
0.031128846,
-0.024092874,
0.013792104,
-0.037391927,
-0.026718037,
-0.0027550894,
0.01060726,
-0.016590502,
-0.033847287,
0.002123784,
0.024985695,
-0.014165224,
-0.0052803103,
-0.0130791785,
-0.029556412,
-0.0035879458,
-0.016830364,
0.030169394,
-0.010127535,
-0.024505971,
-0.021174544,
0.041389637,
0.009174747,
-0.018589357,
0.024719182,
0.0042708884,
-0.00038623723,
-0.008928222,
0.0017390044,
-0.012732711,
-0.0042642253,
0.020215094,
-0.010120872,
0.0072758347,
0.027504254,
0.019935254,
-0.0094345985,
0.0017639901,
0.019375574,
-0.005083756,
-0.0064229895,
0.0033647404,
-0.014191875,
-0.008921559,
-0.028623613,
0.0149914175,
0.005636773,
-0.029050035,
0.00579335,
0.023479892,
-0.024132852,
-0.02714446,
0.011846551,
0.01417855,
-0.013272402,
0.028277144,
0.007169229,
0.00078413443,
0.012326277,
0.003907763,
-0.015924217,
-0.011986471,
-0.016737085,
0.011153614,
-0.010294107,
0.0063996697,
0.013612207,
-0.009881009,
-0.011300197,
-0.016204057,
-0.030435909,
-0.009387959,
0.004247568,
0.005160379,
-0.03198169,
0.01060726,
0.0024852438,
-0.02403957,
0.012099739,
0.008921559,
-0.028223842,
0.0005900788,
0.037605137,
0.1890118,
-0.029556412,
0.011106974,
-0.002926658,
-0.005416899,
0.004440791,
0.00997429,
-0.0113868145,
-0.013685498,
0.016523873,
0.03856459,
-0.008841605,
0.004154288,
0.0077822115,
0.007215869,
-0.022960188,
-0.020654842,
0.007882155,
-0.037338622,
-0.010687215,
-0.011300197,
-0.0078088627,
0.026371568,
0.013232425,
0.025305513,
-0.003674563,
-0.018989129,
0.015084697,
-0.0017806472,
0.0064329836,
0.00024798303,
-0.0008545108,
-0.015657702,
0.016390616,
-0.0024336067,
0.008561765,
-0.03158192,
-0.010367398,
-0.000589246,
0.0035513001,
-0.00072250306,
0.0015940873,
-0.009121445,
0.008961536,
0.0024436011,
0.013239088,
-0.019189015,
0.003268129,
-0.010034256,
0.0038211457,
-0.028863477,
-0.008415182,
0.015577748,
0.022667022,
0.002948312,
-0.027077831,
0.010700541,
0.025865192,
-0.013092505,
-0.013465624,
0.0026684722,
0.008621731,
-0.021694247,
0.019375574,
-0.020654842,
0.025118953,
-0.0027967321,
-0.010567283,
-0.0130791785,
0.00017396291,
0.0036445803,
-0.002959972,
-0.008641719,
-0.0027900694,
-0.0013225762,
-0.023319982,
0.0036012717,
0.0058899615,
0.015191303,
0.029503109,
-0.012912608,
-0.010407375,
-0.05130396,
-0.002954975,
-0.024985695,
-0.034406967,
0.020974658,
0.00600323,
-0.03536642,
-0.012179694,
-0.00190391,
-0.011799911,
-0.015857588,
0.0024069555,
0.033367563,
-0.015124675,
-0.0014516689,
0.0052669845,
-0.003153195,
-0.0008145337,
-0.024212806,
0.08965534,
0.0020638185,
-0.0005867474,
-0.010700541,
-0.002060487,
0.0046006995,
0.01619073,
-0.011799911,
0.00081411726,
0.023120098,
-0.04184271,
0.0022020726,
-0.01693697,
0.010947066,
0.026504826,
0.0047472822,
-0.026664734,
0.007715583,
-0.008921559,
-0.02116122,
-0.007962109,
0.009487902,
0.002571861,
-0.008541777,
0.0058999555,
-0.0026068408,
0.016084125,
-0.018855872,
-0.023240028,
-0.011899854,
-0.00380782,
0.0031282092,
-0.0021471041,
0.0020338357,
0.030222697,
0.013412321,
-0.012013122,
-0.004057677,
0.017923072,
-0.014138572,
0.00063380384,
0.02252044,
0.020734796,
0.030915635,
0.025492072,
-0.0007349959,
0.008228622,
-0.011719957,
-0.008881582,
-0.020295048,
-0.024892416,
-0.0034746774,
-0.021054612,
0.013299053,
-0.019522157,
0.00044557825,
-0.00053427747,
-0.006293064,
0.0002608923,
-0.020241745,
0.011366826,
-0.009447925,
0.010613924,
-0.014058618,
-0.0075023714,
-0.1663048,
0.006796109,
0.026424872,
-0.002896675,
0.031075543,
-0.007309149,
-0.0008695022,
-0.02025507,
-0.00070459663,
0.0035779516,
0.027397648,
-0.0049305107,
-0.017936397,
-0.0095945075,
0.012845979,
0.0065562464,
-0.0051037446,
0.052476622,
0.022813605,
0.010993706,
0.032647975,
-0.028410401,
-0.008055388,
-0.023959616,
-0.010314095,
-0.0064496407,
0.027157785,
0.0074623944,
0.0009794392,
-0.02137443,
-0.012059762,
-0.007389103,
0.049091894,
0.006089847,
0.024705855,
0.009814382,
0.000117536874,
-0.00385446,
0.004634014,
0.011973145,
0.042295787,
0.03462018,
0.00078038656,
0.010673889,
-0.030755725,
0.02013514,
0.0028283808,
0.023240028,
0.024026245,
-0.008794965,
0.00062256027,
-0.014485041,
-0.0042742197,
0.019748693,
-0.0045573907,
0.013685498,
0.0059399325,
0.0013325704,
-0.0065295952,
-0.0023053468,
-0.025412118,
-0.0067494693,
0.0069426917,
0.006029881,
0.016390616,
-0.020375002,
0.0026251636,
0.009900998,
-0.015337885,
-0.0023053468,
-0.027477602,
-0.0029383178,
0.02782407,
0.0028000637,
0.019841975,
0.011813237,
-0.0043974826,
0.0059532584,
-0.00025631158,
0.016910318,
-0.01121358,
0.00583999,
-0.016057475,
0.00024319411,
0.021054612,
0.021254499,
0.008095365,
0.0130791785,
-0.021054612,
-0.014818183,
0.02366645,
-0.029209943,
-0.00030253513,
0.0014908132,
0.023093445,
0.036192615,
-0.012039774,
0.0077355714,
-0.021880807,
-0.0011510077,
0.020015208,
-0.024092874,
-0.008355217,
0.026264964,
0.034513574,
-0.018282866,
-0.01675041,
0.0020704814,
0.05756704,
-0.036592383,
-0.01439176,
0.01920234,
0.0023769725,
0.036912203,
-0.0030082779,
-0.0004476604,
0.027317693,
-0.00069751736,
-0.0046540024,
-0.039310828,
0.07814193,
0.00008974029,
-0.0039510713,
0.03536642,
-0.018629335,
-0.00770892,
-0.12515502,
-0.022720326,
0.009687787,
0.01966874,
-0.013438973,
0.009801055,
-0.013119156,
-0.0030382606,
0.0016357303,
0.014125247,
-0.0002475666,
0.014738229,
-0.012646093,
0.004254231,
0.00558347,
-0.024559272,
-0.0034746774,
-0.010027593,
-0.032568023,
0.03211495,
0.0009802721,
-0.003401386,
0.021600967,
-0.005363596,
0.007182555,
-0.0014191875,
-0.021054612,
0.02515893,
-0.0008819951,
0.019455528,
0.01796305,
0.007389103,
0.019522157,
0.021227848,
-0.0069693434,
-0.01768321,
0.016603827,
-0.014684926,
0.051330615,
-0.005356933,
0.002815055,
0.0009419607,
0.005553487,
-0.0034780088,
0.006013224,
0.0017090216,
-0.035473026,
0.005003802,
0.022187298,
-0.010660564,
-0.03006279,
-0.023839684,
-0.028490355,
-0.021121241,
0.023559846,
-0.012759362,
-0.01315247,
0.036565732,
-0.010633912,
0.0070159836,
-0.0010444021,
0.014471715,
-0.019762019,
0.006896052,
0.006363024,
-0.05069098,
-0.0019472186,
-0.02745095,
0.020841401,
-0.02875687,
-0.019308945,
-0.020641517,
-0.012486185,
-0.0066961665,
-0.0057633673,
-0.01439176,
-0.012246322,
-0.01485816,
0.006629538,
-0.010740518,
-0.016737085,
-0.010234141,
0.014525018,
-0.030142743,
0.023799708,
0.03238146,
0.0207881,
-0.0039943797,
0.011706632,
0.0063297097,
-0.0122329965,
0.042695556,
0.008142006,
-0.022107344,
0.0010510649,
-0.0045940364,
-0.013505601,
0.0034380318,
0.010600598,
0.029849578,
-0.027077831,
-0.004877208,
-0.05122401,
0.02515893,
0.011466769,
0.023693101,
-0.014551669,
-0.021894133,
0.002791735,
-0.0069959946,
0.014271829,
0.014844835,
-0.029209943,
0.019841975,
-0.0011759934,
0.0078088627,
-0.015098023,
-0.003384729,
0.027690813,
0.013991989,
0.005646767,
0.0047506136,
0.0147915315,
0.026638083,
0.009574519,
0.013372344,
-0.013445635,
-0.0122329965,
-0.028143888,
0.026011774,
0.0012184691,
-0.019815322,
-0.021387756,
-0.03403385,
-0.014311806,
0.0011776591,
0.0037545173,
-0.016284011,
0.004317528,
0.028410401,
0.0033530802,
0.04053679,
0.018096307,
-0.043948174,
0.0021337783,
0.0054602074,
0.021387756,
0.006652858,
-0.016550524,
0.0042109224,
0.00775556,
-0.01758993,
0.011513408,
0.006013224,
-0.015404514,
-0.03366073,
-0.032568023,
0.013858733,
0.024559272,
-0.016310662,
-0.021760875,
-0.024825787,
0.002525221,
0.020481607,
-0.011066997,
0.01532456,
-0.005403573,
-0.0111869285,
-0.008761651,
0.015950868,
0.007469057,
-0.03462018,
-0.017456673,
0.017643232,
0.011440117,
-0.013925361,
0.021147894,
0.027557557,
-0.01504472,
0.008921559,
0.02779742,
0.008961536,
0.016457245,
-0.0102408035,
-0.0359794,
0.00794212,
0.02717111,
-0.0063230465,
-0.022480464,
0.041736107,
-0.0122929625,
-0.007362452,
-0.00081744866,
0.011553385,
0.004071003,
-0.008301914,
0.007362452,
0.0024802468,
0.018522728,
0.008661708,
-0.0007145909,
0.038191468,
0.0063763494,
0.004057677,
0.0024835782,
-0.015857588,
-0.03669899,
0.0023070127,
-0.031048892,
-0.024625901,
-0.0085018,
0.028623613,
0.004354174,
0.021054612,
-0.020614864,
-0.007608977,
-0.009228051,
0.02109459,
-0.021147894,
-0.015444491,
-0.008874919,
0.030755725,
0.008721674,
0.017150182,
-0.01588424,
-0.009248039,
-0.019961905,
0.019135712,
0.022773629,
-0.027637511,
0.026571454,
0.015031395,
0.020854726,
0.00010426323,
-0.030968936,
-0.0066428636,
-0.0024369382,
-0.031262103,
0.033047747,
0.03675229,
-0.009401284,
0.07798202,
-0.003001615,
-0.031315405,
-0.014724904,
-0.016430594,
0.00202051,
-0.0072891605,
0.023519868,
-0.0065629096,
-0.03083568,
0.016390616,
-0.010800484,
0.0064529725,
-0.022813605,
-0.038271423,
0.005683413,
-0.007688931,
0.008335228,
-0.0013967004,
-0.008541777,
0.019788671,
0.0074090916,
0.010773832,
-0.0001650097,
-0.027370997,
0.017643232,
0.031102194,
-0.0049538305,
0.019175688,
-0.03837803,
-0.001364219,
-0.00051678746,
-0.02838375,
-0.023413263,
0.019828647,
-0.017136855,
0.010214153,
-0.015910892,
0.0073557887,
0.00065962237,
-0.009914324,
0.013232425,
-0.018003026,
-0.016284011,
0.0012817662,
-0.00808204,
-0.017669884,
-0.008921559,
-0.018935826
] |
Members of the conserved family of eukaryotic RNA-dependent RNA polymerases (Rdrs) synthesize double-stranded RNA (dsRNA) intermediates in diverse pathways of small RNA (sRNA) biogenesis and RNA-mediated silencing. Rdr-dependent pathways of sRNA production are poorly characterized relative to Rdr-independent pathways, and the Rdr enzymes themselves are poorly characterized relative to their viral RNA-dependent RNA polymerase counterparts. We previously described a physical and functional coupling of the Tetrahymena thermophila Rdr, Rdr1, and a Dicer enzyme, Dcr2, in the production of approximately | [
-0.03698841,
-0.007001577,
-0.017559731,
-0.023752362,
-0.018480258,
0.03486841,
-0.004104012,
-0.0037413805,
-0.013375523,
-0.011485655,
-0.0006219653,
0.01026526,
-0.009247103,
0.0030021702,
-0.013982233,
0.019819206,
-0.0032445057,
-0.0069004586,
0.027378676,
-0.006893485,
-0.008145261,
0.0011541444,
-0.0053244065,
-0.024923941,
0.0023431573,
0.010913813,
0.00043759856,
-0.029345255,
-0.007074801,
-0.004041249,
0.0027232228,
-0.023166573,
0.004850196,
-0.030600518,
0.012434076,
-0.026499992,
-0.0024041769,
0.0002442968,
0.0128524965,
-0.0016231246,
0.011332233,
-0.0023431573,
-0.012210918,
0.000965855,
0.0037623015,
0.0022455256,
0.023808151,
-0.0025419071,
0.0018584863,
0.012629339,
0.032051045,
0.010648813,
-0.018703416,
-0.0040063807,
-0.0206421,
0.0059659854,
-0.0073502613,
0.015160785,
0.0076571032,
-0.003511249,
-0.016708942,
-0.010823155,
-0.030600518,
0.0048118406,
-0.0014418088,
0.022218151,
0.024101047,
0.0012927464,
-0.0010722036,
-0.009009997,
0.029484728,
0.0041981568,
-0.012155129,
0.013082628,
0.02577473,
-0.028285256,
-0.009693419,
-0.002653486,
0.014686575,
0.0055266432,
0.017671311,
0.0020537495,
-0.0028295715,
0.012894339,
0.004121446,
-0.016360259,
-0.011346181,
0.02344552,
0.0036960517,
0.005760262,
0.04139578,
0.043432094,
0.013236049,
0.02403131,
-0.014700523,
-0.006774932,
0.012127234,
0.021199994,
-0.016820522,
-0.030684203,
-0.023194468,
0.0153142065,
-0.0050315117,
-0.0024425322,
-0.038773675,
0.0066807875,
0.0064890115,
-0.0047734855,
0.013249996,
-0.0064924983,
-0.035649464,
0.018926574,
0.0026639467,
-0.0460542,
0.020879205,
-0.020404994,
0.03154894,
-0.00379717,
-0.0041005253,
-0.019623943,
0.032859992,
0.0201121,
-0.0010416938,
-0.043989986,
0.014421575,
0.0014147857,
0.012671181,
0.014742364,
-0.003622828,
0.007022498,
0.0067086825,
0.0069423006,
0.0075176293,
0.012071444,
-0.02624894,
0.019833153,
-0.03910841,
-0.006994603,
-0.011806444,
-0.03804841,
0.01444947,
0.0063286168,
-0.03947104,
-0.006318156,
0.023041047,
0.0119947335,
0.019344995,
0.0010050819,
0.00012160358,
-0.0052999984,
0.008180129,
0.0014156575,
0.012608417,
-0.016471837,
0.004763025,
0.027824992,
-0.009135524,
0.0030318084,
0.0011829109,
-0.0032218413,
-0.015049206,
-0.0074269716,
0.014079864,
-0.016862364,
0.02391973,
0.024575256,
-0.018354733,
0.01683447,
0.019191574,
-0.01159026,
-0.0036158543,
0.008040655,
-0.024352098,
0.027852887,
-0.009728286,
0.008961182,
-0.0034973016,
-0.0026273348,
-0.017601574,
-0.017127363,
0.025844466,
-0.023501309,
0.017448153,
0.0076152612,
-0.012608417,
-0.024156835,
-0.00031664877,
0.0044701304,
-0.004079604,
0.004152828,
-0.020614205,
0.002711019,
0.021269731,
-0.0127409175,
-0.622164,
-0.029512623,
-0.021660257,
-0.028480519,
0.00017455999,
0.015732627,
0.006583156,
0.020293415,
-0.0059206565,
0.024826309,
-0.000249745,
-0.013870654,
0.023696572,
-0.034366306,
-0.042678937,
-0.031772096,
0.012357365,
0.00060845376,
0.026374467,
0.0069074323,
-0.04889946,
0.009944471,
-0.0060671037,
0.0038773674,
0.0038529595,
-0.025384204,
0.023891836,
-0.000529564,
0.016820522,
0.030656308,
-0.010613944,
0.020139994,
-0.022538941,
-0.012231839,
0.047560513,
0.005491775,
0.0009832892,
0.020614205,
0.034896307,
0.022538941,
-0.021688152,
0.012719996,
0.032664727,
0.005359275,
0.006499472,
0.013800917,
0.00030553446,
-0.001961348,
-0.004034275,
-0.0035949333,
-0.009979339,
0.030293675,
-0.024310257,
0.019721573,
0.013222102,
0.009414471,
0.032246307,
-0.016416049,
0.0028243414,
0.012866444,
0.0054499325,
0.013835786,
-0.0040726303,
-0.009330787,
-0.017573679,
-0.00812434,
-0.023096835,
0.0016780423,
0.01045355,
0.0044038803,
0.010383813,
0.018856836,
0.020725783,
-0.0020624665,
-0.017657364,
0.033055253,
0.0048048673,
0.023947624,
-0.0067853928,
0.03043315,
0.0009309866,
-0.010844076,
-0.022246046,
0.004498025,
0.04995946,
-0.011234602,
-0.000598865,
0.029010518,
-0.016304469,
-0.0075664455,
0.010844076,
0.0100281555,
-0.008228946,
-0.013326707,
-0.019303152,
0.0076710507,
-0.0037901963,
-0.00012694282,
0.0022001967,
-0.007552498,
-0.01846631,
-0.0069423006,
0.008110393,
-0.0034205911,
0.00042016435,
0.008326577,
-0.022622626,
-0.010871971,
0.037797358,
-0.022776047,
0.011011444,
-0.003274144,
-0.0072735506,
0.006175196,
-0.013131443,
-0.026541835,
0.03085157,
0.023208415,
0.011032365,
-0.049289986,
0.0013982233,
0.004417828,
-0.014812102,
-0.012964075,
0.022776047,
0.0012108056,
0.0070992084,
-0.030795781,
0.00592763,
-0.005690525,
0.0035164794,
-0.004853683,
0.013773022,
-0.01391947,
0.003150361,
0.009177366,
0.012601444,
0.00015952298,
0.008758945,
-0.03634683,
-0.030405255,
-0.009086708,
-0.0018794073,
-0.00085427606,
-0.00044522603,
-0.021032626,
-0.0112206545,
-0.003755328,
0.016792627,
-0.0152305225,
0.036012094,
-0.00512217,
-0.008145261,
0.012629339,
0.0037378937,
-0.011743681,
-0.046109986,
-0.012929207,
0.000095615724,
-0.0010730753,
0.0076849977,
0.0135986805,
-0.0052790777,
0.010725523,
-0.025677098,
-0.02403131,
0.014519206,
-0.005310459,
-0.00553013,
-0.023110783,
0.00873105,
0.015077101,
-0.010153681,
0.014756312,
0.012524733,
0.029456833,
-0.0013825325,
0.020865258,
0.011841313,
-0.0046619065,
-0.014756312,
0.0016475325,
-0.012050523,
-0.0086752605,
0.018773153,
0.00213046,
0.042399988,
-0.008528814,
0.01698789,
0.05149367,
0.0092819715,
0.028759466,
0.005952038,
0.0063739456,
0.0019090455,
-0.014616838,
0.031158412,
0.017001837,
-0.0058509195,
0.0370442,
0.019010259,
-0.01592789,
0.012280654,
-0.045273144,
-0.004679341,
-0.008779866,
0.017587626,
-0.013633549,
0.02048868,
0.01963789,
-0.012106312,
-0.026388414,
-0.030767886,
-0.009693419,
-0.0055231564,
0.020711837,
-0.014240259,
0.010069997,
-0.027253151,
-0.005599867,
-0.018354733,
0.005952038,
0.01973552,
-0.010118813,
-0.0051500644,
-0.013779996,
-0.017211048,
0.012155129,
0.005537104,
-0.001664095,
-0.02085131,
0.0050419723,
-0.0022333218,
0.014588944,
0.004107499,
0.024561308,
-0.0077965767,
0.008912366,
0.032134727,
0.008284735,
-0.027183414,
0.00973526,
0.008452103,
-0.0042888145,
-0.014065918,
-0.009037892,
0.018075785,
0.0061786827,
-0.003556578,
0.02094894,
-0.01119276,
0.026876573,
-0.035119463,
-0.0042434856,
0.018898679,
-0.021367362,
0.018773153,
0.012155129,
0.048090514,
0.015537364,
0.013961312,
0.017699206,
0.008717103,
-0.013982233,
-0.0021339469,
0.00091355236,
0.011150918,
-0.01251776,
-0.01725289,
-0.0040203277,
-0.00992355,
0.005551051,
0.0129082855,
-0.036653675,
0.011297366,
0.016360259,
-0.005240722,
0.017155258,
-0.002072927,
-0.010746445,
-0.0034171042,
-0.027727362,
0.02889894,
0.003647236,
-0.015830258,
-0.023849994,
-0.028117888,
0.010864997,
0.006959735,
0.029819466,
0.022413416,
0.01619289,
0.020656047,
0.035119463,
-0.005767235,
-0.0068342085,
0.035593674,
-0.033529464,
0.011806444,
-0.0038808542,
0.021660257,
0.0008978616,
0.0028557228,
-0.018243153,
0.054952618,
-0.005010591,
0.0036332884,
0.017434206,
-0.0029951965,
-0.009044866,
0.00001954538,
0.017057627,
0.005725393,
-0.017601574,
-0.012880391,
-0.0019386837,
-0.019205522,
-0.001624868,
0.031018939,
0.015648942,
-0.022301836,
-0.032832097,
0.0063321036,
0.0063321036,
0.014282102,
0.04159104,
-0.029707886,
0.022273941,
0.019944731,
0.0005147449,
-0.029122097,
-0.037741568,
0.035314728,
-0.012587497,
0.009533023,
0.009316839,
0.0036263147,
0.004477104,
-0.023612889,
0.014923681,
0.012029602,
-0.03179999,
-0.0063739456,
0.010864997,
0.019079994,
-0.0013685852,
0.016904205,
0.03185578,
0.025105257,
-0.011778549,
-0.0015019568,
0.008800787,
0.017155258,
-0.024379993,
0.012441049,
0.009853813,
-0.01212026,
0.015467627,
0.007175919,
-0.032664727,
0.03308315,
0.009379603,
0.011018418,
0.025021572,
0.021674205,
0.0067226295,
0.02450552,
-0.0052163145,
0.0027929598,
-0.021074468,
-0.003457203,
0.010439603,
-0.0067086825,
-0.012231839,
0.016541574,
0.0034850978,
0.0050559198,
0.00021683793,
-0.01577447,
-0.011548418,
0.0036123674,
-0.00293069,
-0.014881838,
-0.021172099,
-0.0013093088,
-0.010488418,
0.028020255,
-0.004634012,
0.012036576,
-0.004386446,
0.0009632399,
-0.003291578,
-0.027057888,
-0.012448023,
0.0055615115,
-0.014965522,
-0.017768942,
0.009979339,
0.0017687002,
0.026806835,
0.0020153942,
-0.018494206,
0.006056643,
0.0026953283,
-0.02058631,
-0.01795026,
0.018187363,
-0.035007887,
-0.006956248,
0.0036053937,
0.00031163642,
-0.018619731,
-0.026193151,
-0.0059834193,
0.008647366,
0.017015785,
0.04139578,
-0.026583677,
0.0039366437,
0.03313894,
0.02175789,
0.0407542,
-0.004518946,
-0.013410391,
-0.008131313,
-0.02566315,
-0.0118273655,
-0.018884731,
0.009930524,
-0.032357886,
-0.019874994,
0.0053034853,
-0.006956248,
-0.021813678,
0.018215258,
-0.006506446,
-0.0042539462,
0.02683473,
0.027546044,
0.020921048,
-0.006300722,
0.026527887,
-0.0006738321,
0.009358682,
-0.010286181,
0.005725393,
0.014616838,
0.014003154,
-0.033892095,
0.020418942,
0.0014941114,
-0.044687357,
-0.008354471,
-0.008689208,
-0.0074548665,
0.053474195,
0.0042051305,
-0.019024204,
-0.013793943,
-0.0012535194,
-0.0070573664,
-0.007664077,
-0.0010983549,
-0.0017442923,
-0.015049206,
0.0036507228,
0.009037892,
0.008912366,
-0.016109206,
-0.036653675,
0.013884601,
0.017685259,
0.011639075,
0.001964835,
0.0033770057,
-0.013612628,
-0.014547101,
-0.011527496,
-0.013508023,
-0.036960516,
0.002433815,
-0.005359275,
0.031186307,
0.019484468,
0.032302096,
-0.010572102,
-0.0041772355,
0.028787361,
0.026165256,
-0.007943024,
0.0040900647,
0.00076623337,
-0.013535918,
0.03344578,
0.016276574,
-0.0042713806,
0.0026308217,
-0.029038412,
0.012482891,
0.012210918,
-0.014909733,
-0.030823676,
0.01592789,
-0.029401045,
-0.036960516,
-0.003179999,
-0.012531707,
-0.0015246213,
-0.019066047,
-0.002512269,
0.033111043,
-0.016667102,
0.016457891,
-0.0135986805,
0.025077362,
0.000080251826,
0.029401045,
-0.0019212494,
0.021939205,
-0.02212052,
-0.0070573664,
-0.020600257,
-0.006764472,
0.026067624,
-0.00061542745,
0.011095129,
0.028619992,
-0.00037483542,
0.012643286,
0.0011628615,
-0.008689208,
-0.028703677,
0.012733944,
-0.015913943,
-0.016876312,
-0.027281046,
-0.019623943,
-0.041423675,
-0.0066005904,
0.0034920715,
-0.014839996,
0.010676708,
-0.010920786,
-0.040084727,
0.030795781,
-0.0043794727,
0.044380516,
-0.0073572346,
0.007245656,
0.030684203,
-0.018926574,
-0.02995894,
-0.011227628,
0.007447893,
-0.018912626,
0.03325052,
0.023082888,
-0.022106573,
-0.020558415,
-0.015634995,
-0.002226348,
-0.017266838,
-0.026792888,
0.012427102,
-0.009574866,
0.0067993402,
0.0045119724,
0.004672367,
0.011039339,
0.016151048,
-0.036793146,
0.012706049,
0.010460524,
-0.01831289,
-0.026862625,
0.01518868,
0.011646049,
0.019484468,
-0.029345255,
-0.0028138808,
-0.014198417,
-0.033278413,
0.0034728937,
-0.0011358385,
-0.00013053861,
0.02926157,
0.010063023,
-0.0058997353,
0.0049513145,
0.00899605,
-0.012113286,
-0.014142628,
-0.023780257,
0.040949464,
-0.0039854595,
-0.0014740621,
0.0075803925,
0.0063042087,
-0.0013921213,
0.0010800491,
-0.0026046704,
0.014379733,
-0.027476309,
-0.006346051,
0.015607101,
-0.0110532865,
-0.0040551964,
0.011415918,
-0.014247233,
-0.009546971,
-0.025593415,
-0.037239462,
0.017392363,
-0.051354196,
-0.016234733,
0.0014139141,
0.029763676,
0.03634683,
0.0065657217,
0.009637629,
-0.012189996,
0.009065787,
-0.0024355585,
0.021785783,
-0.0025052954,
-0.01272697,
-0.028382886,
-0.020209732,
-0.0048397356,
-0.059081037,
0.008061577,
-0.029707886,
-0.031632625,
-0.002259473,
-0.018438416,
0.0022019402,
0.024324205,
-0.018354733,
0.0214371,
-0.0039436175,
0.015886048,
-0.0024965783,
-0.01399618,
0.038773675,
0.007406051,
0.006740064,
-0.0007566445,
0.013152365,
-0.0179921,
0.0028993085,
-0.011562365,
-0.015886048,
0.0076431558,
-0.008326577,
-0.011074208,
0.02217631,
-0.005763748,
0.0017887495,
0.015174733,
0.0035217095,
-0.01166697,
0.010000261,
-0.00068472844,
-0.016848417,
-0.020418942,
0.008744998,
0.0000673941,
0.008117367,
-0.0086752605,
-0.015091049,
-0.0037274333,
-0.026053676,
-0.027546044,
-0.018954469,
-0.013668417,
0.03143736,
0.00666684,
-0.007636182,
-0.0066040773,
0.0032061504,
-0.04541262,
-0.02571894,
-0.0032410189,
0.021464994,
0.028089993,
0.018061837,
0.00077887316,
-0.0016623515,
-0.015439733,
0.019819206,
0.0036576963,
-0.022162363,
0.0063704588,
0.009379603,
0.013724207,
0.01005605,
-0.047755778,
0.003926183,
0.04351578,
-0.02397552,
-0.02138131,
0.011659997,
-0.026527887,
0.0076431558,
-0.014853943,
0.0005984291,
0.0066005904,
0.021994993,
0.0037204595,
-0.023947624,
-0.018884731,
0.008493945,
-0.00053697353,
-0.019805258,
0.0067993402,
-0.014533154,
0.020293415,
0.0036019068,
-0.009435392,
-0.015913943,
0.009567892,
-0.027880782,
0.0059799324,
0.0015359535,
0.015816312,
0.014756312,
0.010606971,
-0.019596048,
-0.009721313,
-0.025342362,
-0.017824732,
0.0005683551,
0.008884471,
-0.001558618,
0.014072891,
-0.008542761,
-0.001140197,
-0.0063495375,
-0.0021531244,
0.006237959,
-0.013870654,
-0.016848417,
0.011750654,
-0.0028208545,
-0.0049234196,
-0.013445259,
0.0061856564,
-0.012148155,
-0.012217891,
0.0119110495,
0.01232947,
0.0010303615,
0.015634995,
-0.012678155,
-0.02666736,
-0.019623943,
-0.0057776957,
0.012134207,
-0.032692622,
0.0153142065,
0.17964205,
0.00086691586,
0.017420258,
0.018075785,
-0.006893485,
-0.008772892,
0.011429865,
-0.020153942,
-0.0152863115,
0.0043132226,
0.016681047,
0.0061961166,
-0.024142887,
0.0026866111,
-0.0022559862,
-0.014149602,
-0.022371573,
-0.015328154,
-0.03584473,
0.0029097688,
0.010509339,
-0.014177497,
-0.010355919,
-0.009491182,
0.032553148,
0.007636182,
-0.046026304,
-0.010230392,
0.006217038,
-0.010369865,
-0.03216262,
-0.018968416,
-0.007175919,
0.0015324667,
0.02270631,
-0.010558155,
0.0020328283,
-0.01566289,
0.0016126641,
0.0075873663,
-0.00846605,
0.026974203,
0.010014208,
-0.0020955915,
-0.000020335367,
0.013103549,
-0.0125735495,
-0.0070085507,
-0.009665524,
-0.00426092,
-0.039136305,
0.011520524,
0.012266708,
0.029484728,
0.010146707,
-0.0076292083,
-0.00062806724,
0.037741568,
-0.003444999,
0.029122097,
-0.03249736,
0.018131575,
-0.024798414,
0.007148024,
-0.0219671,
0.03603999,
-0.013724207,
0.020056311,
0.022315783,
-0.024003414,
0.0055161826,
-0.022273941,
-0.009853813,
0.010537234,
-0.009930524,
-0.00939355,
0.025649203,
0.019289205,
0.023905782,
0.024896046,
-0.012894339,
0.015342101,
-0.045133673,
0.007005064,
0.0062693404,
-0.027099729,
0.031772096,
-0.004041249,
-0.011255523,
0.011492629,
0.0084242085,
-0.007419998,
-0.020363152,
0.005659143,
0.0128246015,
-0.0021949664,
-0.021199994,
-0.005376709,
0.006963222,
-0.018968416,
-0.04619367,
0.09138313,
0.012113286,
0.029177887,
-0.034840517,
0.02778315,
0.010746445,
0.008954208,
0.018033942,
-0.029122097,
0.012266708,
-0.020014469,
0.0198471,
-0.008033682,
-0.0025297033,
0.01598368,
0.03202315,
-0.030656308,
0.005115196,
-0.007510656,
0.004696775,
-0.012078417,
-0.0179921,
0.017434206,
-0.023054993,
0.012071444,
-0.007880261,
-0.0011358385,
0.0055684852,
-0.013926444,
0.0103628915,
-0.0010809208,
0.015132891,
-0.0017172693,
0.01352197,
-0.00625888,
0.038773675,
-0.0068830242,
-0.011924997,
0.0028278283,
-0.009407497,
0.015941838,
0.0050803274,
0.006408814,
-0.010830129,
0.0042818408,
0.020879205,
0.00699809,
-0.010955655,
0.013696312,
-0.030154202,
0.002545394,
0.00486763,
0.008173156,
-0.0060705906,
-0.010572102,
-0.023891836,
-0.02412894,
-0.0064471695,
0.009916577,
-0.028731572,
0.004079604,
0.021213941,
-0.012015655,
-0.012915259,
0.009553945,
-0.17852627,
0.0134871015,
0.011388023,
-0.025621308,
0.021771837,
0.022287888,
0.010620918,
0.0046584196,
0.001570822,
0.0049722353,
0.021688152,
0.024561308,
-0.03550999,
-0.042706832,
0.0153699955,
0.01831289,
-0.016067363,
0.014065918,
0.021046573,
0.002283881,
0.018675521,
-0.033892095,
-0.0030928282,
-0.026541835,
0.002304802,
0.011269471,
0.0227621,
-0.01683447,
-0.014219338,
-0.014672628,
-0.041842096,
0.014121707,
0.016904205,
-0.023808151,
0.030293675,
-0.0030422688,
0.0054464457,
-0.0029481242,
-0.0052093407,
0.016374206,
0.0036925648,
0.027155519,
0.020307362,
-0.023961572,
0.005875327,
0.032608937,
0.0029690452,
-0.011834339,
-0.0100281555,
0.0015603614,
0.00051387324,
-0.008438156,
-0.0056661167,
-0.0068830242,
0.021660257,
0.012915259,
0.0020659533,
0.04106104,
-0.004529407,
-0.012761839,
-0.00897513,
-0.0038320385,
0.038187884,
-0.011011444,
0.013849733,
-0.015174733,
-0.003499045,
0.006844669,
-0.0072805244,
0.01740631,
-0.026332624,
-0.004323683,
-0.008486971,
-0.025649203,
-0.0034066439,
0.016416049,
-0.0061786827,
0.020558415,
-0.0004742104,
-0.024491573,
-0.0019962166,
0.030209992,
-0.017113416,
-0.019275257,
0.003499045,
-0.020139994,
-0.0049059857,
0.01662526,
0.012950128,
-0.008228946,
0.026527887,
-0.010090918,
0.023194468,
-0.008870524,
0.019414732,
0.017601574,
-0.0014470391,
-0.020683942,
0.0014095556,
-0.0009344734,
-0.0013154108,
-0.02566315,
0.006774932,
0.012615391,
0.011562365,
0.010383813,
-0.016178943,
0.0018706903,
0.0529163,
-0.016429996,
0.012831575,
0.0061089457,
0.01312447,
0.024226572,
0.016653154,
0.038076304,
-0.03232999,
0.0066145374,
-0.002602927,
-0.03481262,
0.079611555,
0.01318026,
-0.015816312,
0.0074618403,
-0.004759538,
-0.02524473,
-0.11715786,
-0.009288945,
-0.0028365452,
0.011680918,
-0.016095258,
0.016918153,
0.0049129594,
0.026207099,
-0.007116643,
0.0006180426,
0.0012918747,
0.005599867,
0.002428585,
-0.017685259,
0.00040251223,
-0.01251776,
-0.010579076,
-0.035258938,
-0.017113416,
0.03207894,
-0.0050384854,
-0.0052511827,
-0.003066677,
-0.0038111175,
0.019456573,
0.0045049987,
-0.014093812,
-0.0050001303,
0.0060287486,
0.029345255,
-0.022399468,
-0.010341971,
0.014296048,
-0.0061577614,
-0.019079994,
-0.014156575,
-0.0050698672,
-0.026011836,
0.037183672,
-0.004156315,
0.0066773007,
0.0026796374,
-0.0019282232,
0.007113156,
0.016946048,
-0.0033648016,
-0.0068795374,
0.021660257,
-0.0037867094,
0.010209471,
-0.04599841,
-0.02677894,
-0.037769463,
-0.014853943,
0.009839865,
-0.027643677,
0.019693678,
0.036012094,
-0.0093098655,
-0.01444947,
0.004110986,
0.00048554264,
-0.0045398674,
0.0085636815,
-0.013703286,
-0.017350521,
-0.019079994,
-0.01725289,
0.020335257,
-0.018647626,
0.007678024,
-0.004518946,
-0.007294472,
-0.004229538,
-0.0174621,
0.02069789,
-0.042567357,
-0.021674205,
0.016416049,
-0.025119204,
-0.009693419,
-0.025328415,
0.01947052,
-0.030991044,
0.018703416,
0.008989076,
0.017364468,
-0.00042866354,
0.0040063807,
-0.023794204,
-0.024324205,
0.024561308,
-0.017545784,
-0.0033316768,
-0.0031276965,
0.031214202,
-0.028982624,
-0.018173415,
-0.00166671,
0.00039619234,
-0.029875254,
-0.013759075,
-0.0645484,
0.0060392087,
0.00035652952,
-0.0041388804,
0.017155258,
-0.015509469,
0.0035391438,
-0.008835656,
0.009616707,
0.015816312,
-0.043571565,
0.004344604,
-0.0022856244,
-0.017503943,
-0.03668157,
-0.033641044,
0.027294993,
-0.0193171,
0.029819466,
0.017643416,
-0.014079864,
0.025314467,
0.0011279931,
0.035091568,
-0.012796707,
-0.01106026,
-0.0023972034,
0.00592763,
-0.00891934,
0.024533415,
-0.012392233,
-0.035119463,
-0.015816312,
0.00036284942,
-0.010767366,
0.001730345,
-0.015411838,
0.0338642,
0.009672497,
0.042511567,
-0.02592815,
-0.05774209,
-0.0112206545,
0.0066389455,
0.007510656,
-0.004714209,
-0.033529464,
0.00732934,
-0.007873287,
0.00459217,
0.018061837,
0.0027023018,
-0.021186046,
-0.028424729,
-0.017392363,
0.0046270383,
-0.012371313,
-0.019596048,
0.007489735,
-0.008033682,
0.015690785,
0.017880522,
0.009149471,
-0.009358682,
-0.0025227296,
-0.014177497,
-0.026081571,
-0.01704368,
-0.00406217,
-0.037462622,
-0.038550515,
0.023584994,
0.012036576,
0.009533023,
0.005945064,
-0.014177497,
-0.02323631,
0.0033804926,
-0.01608131,
0.014965522,
-0.0006577054,
0.0064192745,
-0.02079552,
0.02762973,
0.019400785,
0.0022106573,
0.025426045,
0.01740631,
-0.002632565,
0.021395257,
0.020879205,
0.032190517,
0.011980786,
0.007810524,
0.014379733,
0.008863551,
-0.0044701304,
0.0034066439,
0.005578946,
0.021883415,
0.02318052,
0.016067363,
0.00008918686,
-0.031186307,
-0.00074749155,
0.033836305,
-0.029010518,
-0.012984997,
-0.0069736824,
-0.011890128,
0.0034676634,
-0.015676837,
-0.009079735,
0.019902889,
-0.000027758524,
0.007043419,
-0.0153142065,
-0.04170262,
-0.0011245062,
0.005467367,
0.012761839,
0.018661574,
0.01704368,
0.020446837,
0.014219338,
0.023501309,
0.039973147,
-0.019958679,
0.03043315,
-0.0048780907,
0.0240871,
-0.0025052954,
-0.01603947,
-0.022845782,
-0.009944471,
0.008500919,
-0.012796707,
0.019707626,
-0.027057888,
0.08686419,
0.022148415,
-0.015063154,
0.0034938147,
-0.030516833,
0.023319993,
0.005505722,
0.00538717,
-0.0076082875,
-0.025788678,
0.015174733,
-0.0012003451,
0.024142887,
-0.02043289,
-0.005010591,
0.019303152,
0.0017068087,
0.042483672,
-0.028187623,
-0.030656308,
0.00066206395,
-0.007134077,
0.0043097357,
0.0037134858,
-0.012203944,
-0.00606013,
0.041312095,
-0.002052006,
0.00846605,
-0.03378052,
0.012162102,
-0.007573419,
-0.03344578,
-0.003030065,
0.0040203277,
-0.0059624985,
-0.009330787,
-0.0012360852,
0.041256305,
0.019066047,
-0.0013781739,
-0.033417884,
-0.017699206,
-0.020558415,
0.01524447,
0.01018855,
-0.002810394,
-0.0024198678,
-0.006053156
] |
Type VI protein secretion system (T6SS) is important for bacterial competition through contact-dependent killing of competitors. T6SS delivers effectors to neighboring cells and corresponding antagonistic proteins confer immunity against effectors that are delivered by sister cells. Although T6SS has been found in more than 100 gram-negative bacteria including many important human pathogens, few T6SS-dependent effector and immunity proteins have been experimentally determined. Here we report a high-throughput approach using transposon mutagenesis and deep sequencing (Tn-seq) to identify T6SS immunity proteins in Vibrio cholerae. Saturating transpos | [
-0.023189057,
-0.0033074352,
0.003933257,
-0.031035382,
-0.00087396364,
0.036984056,
-0.015517691,
0.0006905911,
-0.018545862,
-0.0057770764,
0.0092931185,
-0.015019726,
0.0051714424,
0.013182635,
0.0042966376,
-0.0042158864,
0.036257293,
0.0017083929,
-0.0052420995,
-0.019541794,
-0.0047744154,
0.0009362094,
0.005571834,
-0.0012112682,
-0.007879972,
-0.0009698557,
0.01562536,
-0.041775294,
-0.033673257,
0.0033612694,
-0.0013147307,
-0.017011588,
-0.019824423,
0.017065423,
-0.008687485,
-0.02242192,
0.011332087,
0.005642491,
0.029016603,
-0.0070724604,
0.01948796,
0.021022232,
-0.0147101795,
0.002876762,
0.005965496,
0.0019464407,
-0.0072205043,
-0.0011094881,
-0.00817606,
0.00030302734,
0.033942427,
-0.004404306,
-0.039864182,
0.00181522,
-0.0066586104,
-0.01121096,
0.0057669827,
-0.0004781986,
0.007341631,
-0.018290149,
0.0061741034,
0.0042629912,
-0.040590942,
-0.01139265,
0.00909797,
0.0008298028,
-0.027778417,
-0.0066787982,
0.011816594,
0.010443823,
0.035638202,
0.048692983,
-0.00973725,
-0.0015982011,
0.012529897,
-0.029716447,
-0.024790622,
0.008398126,
-0.008095309,
0.007415653,
0.013007674,
-0.014844765,
-0.0025503924,
0.010356343,
0.014292965,
-0.021251028,
0.016298287,
0.015584984,
-0.015558067,
0.0008268588,
0.0033074352,
0.029393442,
0.01553115,
0.030389374,
-0.02298718,
0.014373716,
-0.018788116,
0.019972466,
0.0064197215,
-0.027724583,
-0.011910804,
0.0017899852,
-0.0129740285,
-0.021372154,
-0.01461597,
-0.0067595495,
-0.0025133814,
-0.01149359,
0.020053217,
-0.015759945,
-0.032488905,
0.02380815,
-0.024386866,
-0.03410393,
0.02931269,
0.011130209,
0.027616914,
-0.00652739,
-0.020968398,
-0.017792184,
0.021735534,
-0.00022227612,
0.0027203064,
-0.0023384206,
0.034803774,
-0.0023855255,
-0.00027421766,
-0.0025773095,
-0.004061113,
0.009346953,
-0.017348053,
0.029985618,
0.016150244,
0.00055642636,
-0.016675126,
0.008835529,
-0.036526464,
-0.022220042,
-0.0058342754,
-0.015410023,
0.011123479,
0.030846963,
-0.008182789,
0.001889242,
0.020335848,
0.011863699,
0.021991247,
0.026594067,
-0.010861038,
0.032300487,
0.0050402214,
-0.03060471,
-0.023215974,
-0.017482638,
0.008660568,
0.018236315,
-0.0008537758,
0.05477624,
-0.0058746506,
-0.04374024,
-0.022045081,
-0.006672069,
0.015235063,
0.00023173916,
0.048854485,
0.030550877,
-0.0014324929,
0.017038506,
0.013371055,
0.0032233193,
0.0030163943,
0.0030433114,
0.0014139874,
0.016379038,
-0.0028195633,
0.021035692,
0.007462758,
0.02234117,
-0.0024881468,
-0.030550877,
-0.0035967936,
0.019797506,
0.032461986,
-0.00077933335,
-0.017146174,
-0.0077117407,
0.017805643,
0.0024999229,
0.027670749,
-0.014777472,
0.007159941,
0.0077386578,
0.0047037583,
-0.0054271542,
-0.6223227,
-0.035072945,
0.006682163,
-0.0114128385,
0.00082727935,
0.0061169043,
0.0033511755,
-0.008862446,
-0.0124424165,
0.020981858,
-0.01635212,
-0.00021186679,
-0.01699813,
-0.044816922,
-0.0023417852,
-0.038356826,
0.0036506278,
-0.018424734,
0.04411708,
-0.0030853692,
0.0042966376,
0.00040880303,
0.002213929,
0.04648578,
0.016944297,
0.00036674508,
0.0121194115,
-0.025032876,
-0.023390936,
0.021062609,
-0.027253535,
0.020255096,
-0.010430365,
-0.0021146724,
0.040402524,
-0.003509313,
0.004017373,
0.024198446,
0.027455412,
0.038895167,
-0.018989993,
-0.018976536,
-0.012395311,
0.020389682,
-0.0016806347,
0.020174345,
0.016755877,
0.0074694874,
0.008768236,
-0.0043134606,
0.0052219117,
0.006863853,
-0.008007829,
0.018276691,
0.011244606,
0.0028784443,
0.040644776,
-0.01865353,
0.0004395053,
0.002913773,
-0.006820113,
0.011897345,
-0.0167155,
-0.011769489,
-0.028236007,
-0.008169331,
-0.025019418,
-0.0012987487,
0.01792677,
0.0031577088,
-0.006581224,
0.024575286,
-0.006312053,
0.016136784,
0.001215474,
0.036230378,
-0.006651881,
0.005652585,
0.0077117407,
0.01167528,
-0.020901106,
0.0055852924,
-0.016580915,
0.0045893607,
0.025746178,
0.0032048137,
-0.016015658,
0.022664174,
0.0046734763,
-0.015490774,
0.004374024,
-0.009966046,
-0.015665736,
-0.008707672,
-0.03178906,
0.040402524,
0.015665736,
-0.015383106,
0.014091087,
-0.0064365445,
-0.026580608,
-0.019918632,
0.035826623,
0.0016049304,
0.030281706,
0.011533965,
-0.01570611,
0.023229433,
0.017872935,
0.004643195,
0.0027724584,
-0.009878566,
-0.010167924,
0.0016663349,
0.0022105644,
-0.02205854,
0.05324197,
0.035718955,
-0.0026832956,
-0.03711864,
0.023027554,
0.0015208145,
-0.000071866474,
0.004569173,
0.004888813,
0.046754953,
0.004717217,
-0.021722076,
-0.015800321,
-0.007509863,
-0.0029390077,
0.0032990235,
0.02931269,
-0.013889208,
0.015733028,
0.021224111,
0.02481754,
0.017294219,
0.007671365,
-0.030631626,
0.0022475754,
-0.019312998,
-0.00964977,
0.00050890085,
-0.019003453,
-0.027253535,
-0.02738812,
-0.013835374,
0.007408924,
-0.039029755,
0.024090778,
0.009037406,
-0.0032367778,
-0.0076780943,
0.012913465,
-0.02205854,
-0.01617716,
-0.0076848236,
-0.023310184,
-0.005386779,
0.002748906,
0.006261584,
-0.0016814758,
0.0013576298,
-0.010450553,
-0.017011588,
0.014898599,
0.008970114,
0.003152662,
-0.029070437,
0.0018455017,
-0.019622546,
0.004350472,
0.025786554,
-0.0020204626,
0.032031316,
-0.009515185,
0.0069513335,
-0.0014232402,
-0.0046734763,
0.00085167296,
-0.031977482,
-0.022018164,
0.02213929,
0.03143914,
-0.0008285411,
0.03536903,
-0.0033309876,
0.008283729,
0.037603147,
-0.0012062213,
-0.031277638,
-0.01728076,
0.018142106,
-0.0020675675,
-0.006120269,
0.040537108,
0.006672069,
0.017146174,
0.0069311457,
0.020699227,
-0.0041889693,
0.0039029752,
-0.03978343,
0.0051949946,
-0.003317529,
-0.0002796852,
-0.02858593,
0.034696106,
0.021883579,
-0.0025234753,
-0.005615574,
-0.005332945,
-0.009528643,
0.0023905723,
0.017415345,
0.017603764,
-0.012529897,
-0.017119257,
-0.011634904,
-0.03509986,
-0.0027219888,
0.026351813,
0.0066384226,
-0.019501418,
0.015208146,
0.013774811,
-0.00835775,
-0.000012610805,
-0.0118838865,
0.004155323,
-0.00643318,
0.02150674,
-0.0009698557,
0.024857916,
0.0062481253,
0.011419567,
0.0025705802,
0.029366525,
-0.0017344687,
-0.01148686,
0.019191872,
0.0019464407,
-0.022933345,
0.0019060652,
0.012677941,
0.00973725,
0.0042932727,
0.006056341,
0.0072205043,
-0.006608141,
0.025234753,
-0.03711864,
-0.00085419643,
-0.0085865455,
-0.024844456,
-0.0025251578,
0.017038506,
0.03776465,
0.0069311457,
0.0075771557,
0.002430948,
0.018518945,
-0.01452176,
0.007159941,
0.0060025067,
-0.022650715,
0.015127394,
-0.0034487497,
-0.013794999,
-0.03905667,
0.0034622082,
0.014804389,
-0.0037515669,
0.014992809,
0.017065423,
0.009824731,
-0.005430519,
-0.002770776,
-0.014925516,
-0.009346953,
-0.020147428,
0.02510017,
0.009414245,
-0.0057871705,
0.009844919,
-0.017294219,
-0.0048215203,
-0.005982319,
0.030416291,
0.017038506,
0.030200955,
0.018343983,
0.006359158,
-0.023740856,
0.010881226,
0.015154311,
-0.029904867,
0.009501726,
-0.006601412,
0.014037252,
-0.002876762,
-0.005450707,
-0.019985925,
0.043524902,
0.0030029358,
-0.016769335,
-0.003433609,
-0.010208299,
-0.023579353,
-0.0014526807,
0.012778879,
-0.019703297,
-0.012765421,
0.010430365,
0.0006418039,
-0.021089526,
-0.007853055,
0.012637565,
-0.005497812,
-0.021062609,
-0.049204405,
0.014319882,
-0.021923954,
0.01838436,
0.0076579065,
-0.0068705822,
0.015450398,
-0.005403602,
-0.005154619,
-0.02215275,
-0.027778417,
0.018626614,
-0.01526198,
-0.00060437236,
0.008465419,
0.007018626,
0.0046902997,
-0.0065408484,
0.028128339,
0.005255558,
-0.0027556352,
0.0072205043,
0.01461597,
-0.0019868163,
-0.016190618,
0.00919218,
0.0016974577,
0.009501726,
-0.01709234,
0.00817606,
0.01920533,
-0.0018690542,
-0.018815033,
0.0018236316,
0.018249774,
0.030631626,
-0.0129740285,
-0.008727861,
-0.035584368,
-0.012725045,
0.017953686,
-0.0135931205,
-0.0017294218,
0.025140544,
0.010618784,
0.0051209726,
0.02270455,
-0.008276999,
-0.0019380291,
-0.012940382,
0.0119713675,
-0.019810965,
-0.018209398,
0.004485057,
-0.019541794,
-0.014912058,
-0.037926152,
0.006285136,
0.007314714,
-0.0013206188,
0.008875905,
-0.012200163,
-0.026715193,
-0.019232247,
-0.013640226,
-0.005356497,
0.011782948,
0.0002817881,
-0.0059991423,
0.0011406109,
-0.025369339,
-0.010484199,
-0.009696875,
0.008653838,
-0.02923194,
-0.009992963,
-0.00045422558,
0.017226925,
0.012725045,
-0.0006035312,
-0.022812217,
-0.005645856,
0.011614717,
-0.020806896,
-0.0061741034,
0.015975282,
-0.040671695,
0.025840389,
0.02573272,
0.02655369,
-0.020914564,
-0.0065576714,
-0.012469334,
0.0078194095,
0.0029524663,
0.0012028567,
0.0024023487,
-0.007489675,
0.00500994,
0.011433026,
0.027616914,
-0.02040314,
-0.0052992986,
-0.009609395,
-0.04392866,
0.015504233,
-0.0089970315,
0.020430056,
-0.013519099,
-0.016823169,
0.009414245,
-0.010215028,
-0.009770897,
0.0104101775,
-0.0051445253,
0.0012718316,
0.0071733994,
0.008081851,
0.024763705,
-0.0015199734,
0.012751962,
0.0026597432,
0.006503837,
-0.01958217,
0.0053935084,
0.006305324,
0.0029019967,
-0.023767773,
0.0025941327,
0.014010335,
-0.031331472,
-0.029420359,
-0.0133575965,
-0.010396719,
0.008889363,
0.011560882,
-0.013720977,
-0.028047588,
-0.014508301,
-0.010134277,
0.019770589,
-0.0018875597,
-0.017294219,
-0.028962769,
-0.008108768,
0.003164438,
-0.015450398,
0.0010413541,
-0.030039452,
-0.0011759396,
0.013478723,
0.0057333363,
0.011843511,
0.008923009,
-0.008081851,
-0.0113253575,
0.014817848,
-0.033027247,
-0.041667625,
-0.022664174,
-0.0060529765,
0.053807225,
0.04365949,
0.015598442,
-0.0038827874,
0.031842895,
0.03353867,
0.008478877,
0.0014686626,
-0.012173246,
0.002467959,
-0.020430056,
0.024804082,
0.024467617,
-0.01516777,
0.00009983499,
0.012415499,
0.024777165,
0.022569964,
-0.005164713,
-0.012624106,
-0.012139599,
-0.017226925,
-0.00781268,
0.009064323,
-0.004602819,
0.0031778966,
-0.041048534,
-0.012987487,
0.018343983,
0.001704187,
0.010423636,
0.010638973,
0.03170831,
0.012166516,
0.021735534,
-0.0053632264,
0.0036338046,
-0.008828799,
-0.030820046,
-0.0038289533,
-0.010282321,
0.038249157,
-0.018532403,
0.004542256,
0.022125833,
0.0027186242,
-0.006884041,
0.01056495,
-0.01387575,
-0.036418796,
-0.0072676092,
-0.009575748,
-0.030389374,
-0.01304805,
-0.016567457,
-0.068046354,
0.0051512546,
-0.0031997669,
-0.015033185,
0.0061741034,
-0.012200163,
-0.007065731,
0.021035692,
0.021614408,
0.048935235,
-0.0045994543,
0.025665427,
0.024575286,
-0.00983819,
-0.007415653,
-0.0063894396,
0.009555561,
-0.00528584,
0.033673257,
0.028236007,
0.0017916675,
-0.017617224,
0.006238031,
0.0038693289,
-0.012940382,
-0.03114305,
0.008835529,
0.009643041,
0.009320036,
-0.018505486,
0.0009336859,
-0.031277638,
0.013128801,
-0.02656715,
0.007563697,
0.0050200336,
-0.0010001374,
-0.03649955,
-0.0003360428,
0.017388428,
0.024696413,
0.0074425703,
-0.025786554,
-0.022448838,
-0.030389374,
0.00074190175,
-0.01718655,
0.0024915114,
0.033242583,
0.027670749,
0.0107937455,
0.028101422,
0.022368087,
0.011910804,
0.0032552832,
0.0020288741,
0.04110237,
-0.012603919,
-0.008108768,
-0.0010724771,
0.02150674,
0.0021903766,
-0.018263232,
0.0055819275,
-0.00753678,
-0.018545862,
-0.012778879,
0.02610956,
0.028693598,
-0.006305324,
-0.004612913,
-0.025746178,
-0.00211299,
-0.033296417,
-0.0017016636,
0.017469179,
-0.031304553,
-0.014750555,
-0.029124271,
0.011668551,
0.034292348,
0.013027863,
0.009333494,
0.0020036395,
0.03905667,
-0.03087388,
0.016311744,
0.006238031,
0.013438348,
-0.02242192,
0.0014695039,
-0.009044136,
-0.029124271,
0.02508671,
-0.02205854,
-0.009212367,
-0.00827027,
-0.010834121,
0.01939375,
0.003936622,
-0.012307831,
0.020282013,
0.004495151,
0.01857278,
0.0012112682,
0.012469334,
0.024144612,
-0.0018488663,
0.016338661,
0.004612913,
-0.0057097836,
-0.009811273,
-0.006826842,
-0.015558067,
-0.030039452,
0.008970114,
-0.038087655,
-0.00047146934,
-0.029339608,
0.013256658,
-0.010524575,
0.008418314,
-0.0067864666,
-0.021291403,
0.007489675,
0.009952587,
-0.02213929,
-0.015679194,
0.0007553603,
0.014360257,
-0.013243199,
-0.02298718,
0.0050671385,
-0.006241396,
-0.011533965,
-0.020605018,
0.008236623,
-0.00450188,
0.042205967,
-0.0039736326,
-0.020968398,
-0.006083258,
0.015733028,
-0.034588438,
-0.01314226,
-0.02738812,
-0.0012566907,
0.0071733994,
0.02205854,
-0.020510808,
0.008620192,
0.0034689375,
0.0009967728,
0.008303916,
-0.018774657,
-0.0009151804,
-0.0020406505,
0.007832868,
0.008135685,
-0.04915057,
0.005514635,
0.057279527,
-0.01920533,
-0.0031863083,
0.019070745,
-0.012637565,
0.017482638,
-0.008398126,
0.017523013,
-0.007826138,
0.013162448,
0.02087419,
-0.018074812,
-0.028882017,
0.013613309,
-0.005790535,
-0.009151804,
-0.0040039145,
0.009252743,
0.0020238273,
-0.009595936,
-0.013337409,
-0.03932584,
-0.0050469507,
0.009259473,
0.019514877,
0.012388582,
0.005625668,
-0.00088153407,
0.0116483625,
-0.013889208,
-0.021574033,
-0.0021197193,
-0.014952433,
0.022112373,
-0.004034196,
-0.0086740265,
-0.02904352,
-0.00020692499,
0.004495151,
-0.022166207,
0.0065677655,
-0.016796252,
-0.021466365,
-0.019447584,
0.0037347437,
0.0065139313,
-0.0056828666,
-0.0015687606,
0.0021096254,
-0.022004705,
-0.02048389,
-0.004602819,
-0.0010413541,
0.011682009,
-0.0039736326,
0.0011801453,
0.006066435,
-0.013216282,
-0.02619031,
0.0067662788,
-0.046754953,
0.0015384789,
0.18389744,
-0.014198755,
0.001783256,
0.024575286,
0.0053901435,
-0.00032489747,
-0.01644633,
-0.0044648694,
0.020847272,
0.014898599,
0.022179667,
-0.007953995,
0.0127385035,
0.004468234,
0.026849778,
-0.022354627,
-0.021089526,
-0.00031669615,
-0.02251613,
-0.009595936,
0.0045826314,
0.0061337277,
0.0022055176,
-0.002346832,
0.025059793,
0.004081301,
-0.027253535,
0.010073714,
0.01921879,
-0.01158107,
-0.028962769,
-0.008472148,
0.034130845,
-0.009569019,
0.003253601,
0.020160886,
0.0077117407,
0.003556418,
0.0023737492,
0.014629428,
-0.019191872,
0.011049458,
-0.00376839,
-0.021304863,
-0.0061505507,
-0.01065916,
-0.026580608,
0.014898599,
-0.007698282,
-0.0057770764,
-0.042582806,
-0.001411464,
0.014562136,
0.02205854,
0.012092494,
-0.005938579,
0.01350564,
0.0027472235,
-0.0012322972,
0.022246959,
-0.014777472,
0.018276691,
-0.05009267,
0.034507684,
-0.005911662,
0.055503,
-0.009151804,
0.0271997,
0.013223011,
-0.036687966,
-0.002669837,
-0.0064432737,
-0.011446484,
-0.00726088,
-0.045759022,
0.00017338379,
-0.0019127944,
0.0068806764,
0.037360895,
0.030281706,
0.008862446,
-0.010511116,
-0.04454775,
0.02674211,
0.0059015676,
-0.01775181,
0.021547116,
-0.0009378917,
-0.032112066,
0.01562536,
0.0064903786,
0.0039231633,
-0.021385614,
-0.025611592,
-0.007994371,
-0.011850241,
0.017778726,
-0.0073281727,
0.019541794,
-0.032031316,
-0.028612847,
0.06077875,
0.0019060652,
-0.003433609,
-0.022718009,
0.009420975,
-0.009602665,
0.008445231,
-0.0016898874,
-0.010780287,
0.0073685483,
-0.01286636,
0.015019726,
-0.012099223,
0.0064399093,
0.016284827,
0.021802828,
0.0028666682,
0.033000328,
-0.009602665,
0.025005959,
-0.0183709,
0.0049998458,
0.025005959,
-0.0065576714,
0.009663229,
-0.017765267,
0.029366525,
-0.015369647,
-0.023835067,
0.015733028,
0.008660568,
0.0064096274,
-0.0038255889,
-0.0061236336,
-0.009992963,
0.0093805995,
-0.0015014679,
-0.021116443,
0.012933653,
-0.008983573,
-0.01534273,
-0.00473404,
0.004919095,
0.015208146,
-0.04621661,
0.019541794,
0.007866514,
-0.0006821795,
-0.016190618,
0.0002428845,
-0.016392495,
-0.006066435,
-0.016823169,
0.010955248,
-0.03843758,
-0.01020157,
-0.031304553,
0.017307676,
-0.01387575,
-0.024131155,
0.01699813,
0.032488905,
-0.004178875,
-0.009131616,
0.007664636,
-0.16914688,
0.023296725,
0.008573087,
-0.009804543,
0.02361973,
0.004670112,
0.009299848,
0.024494534,
-0.0068133837,
0.004575902,
0.04007952,
0.0108543085,
-0.037979987,
-0.029931784,
-0.017805643,
0.0042932727,
-0.028262924,
0.0069782506,
-0.0015039913,
0.007920348,
0.038087655,
-0.010443823,
-0.010652431,
0.0057097836,
-0.00909124,
0.022933345,
-0.0020709322,
0.016877003,
-0.0098516485,
-0.010127548,
-0.007980912,
-0.010726453,
0.015558067,
-0.018613154,
0.023014097,
0.015410023,
0.0059957774,
0.0022761747,
0.025382798,
0.022085456,
0.04201755,
0.0050200336,
-0.0068604886,
0.0030063004,
-0.030416291,
0.0031223802,
-0.008276999,
0.005282475,
0.03087388,
-0.023121765,
0.009569019,
-0.017146174,
0.008943197,
0.026782487,
0.0145352185,
-0.01617716,
-0.008620192,
0.008741319,
-0.008236623,
0.03501911,
-0.008808612,
-0.02213929,
0.0288551,
-0.014077628,
-0.010141007,
-0.041183118,
-0.01920533,
0.0011851923,
-0.011702197,
0.0059991423,
-0.0216817,
-0.005531458,
-0.018895784,
-0.019097662,
0.013761353,
0.022448838,
-0.020133968,
0.013445077,
-0.009212367,
-0.0008588228,
0.0041654166,
0.01084758,
-0.014252589,
-0.001173416,
-0.026055725,
0.010679348,
-0.018222857,
0.0017344687,
0.006749456,
0.00964977,
0.017523013,
-0.02251613,
0.01222035,
-0.018949619,
0.01562536,
0.022623798,
-0.00542379,
0.006863853,
-0.0003118595,
0.0052252766,
0.0097641675,
-0.0053363093,
0.003859235,
0.0064735557,
-0.00032573863,
-0.0070522726,
-0.0048820837,
-0.012099223,
0.05081943,
0.009730522,
-0.030389374,
-0.020887647,
0.011850241,
0.01958217,
-0.000078017445,
0.039541177,
0.00047146934,
-0.011453214,
-0.0034790314,
-0.023956193,
0.07106107,
-0.00495947,
-0.011621445,
0.0032435071,
0.008209706,
-0.039379675,
-0.13824607,
-0.017334593,
0.010881226,
0.01756339,
-0.028962769,
0.00363044,
-0.0028582565,
0.013263387,
-0.02508671,
0.022906428,
0.002972654,
-0.036714885,
-0.009629582,
-0.01194445,
0.005800629,
0.016984671,
-0.009326765,
-0.00071834936,
-0.0075906143,
0.029797198,
0.010612056,
-0.0056021153,
0.0051714424,
0.0015746487,
0.008647109,
-0.022045081,
-0.02030893,
0.034669187,
0.009246014,
0.014400633,
0.033673257,
-0.0037448376,
0.004522068,
-0.0051176082,
-0.03208515,
0.009124887,
0.0048282496,
-0.019757131,
0.03841066,
-0.0073214434,
-0.011103292,
-0.0025386163,
0.013108614,
0.009508455,
0.0064567323,
-0.009582478,
0.007415653,
0.009972774,
0.038222242,
-0.021910496,
-0.038625997,
-0.04583977,
-0.058033206,
-0.017536473,
0.02858593,
-0.016069492,
-0.0018488663,
0.04137154,
0.0053363093,
0.016890462,
-0.0041149473,
-0.0012499614,
-0.0030634992,
0.02251613,
0.008842258,
-0.014306423,
-0.00090424536,
-0.023296725,
0.01901691,
-0.03356559,
0.0017395157,
-0.011385921,
-0.014562136,
-0.006497108,
-0.033296417,
0.0041856044,
-0.023646647,
-0.015369647,
-0.0012087447,
-0.010154465,
0.0011002353,
-0.02003976,
0.009542102,
-0.015127394,
0.031654477,
0.0038255889,
0.00090845115,
0.017724892,
-0.0020524266,
-0.0027304003,
-0.02571926,
0.033296417,
-0.0072003165,
-0.010275592,
0.004010644,
0.03208515,
-0.035692036,
-0.013431619,
0.013310492,
-0.014965892,
-0.035046026,
-0.0061169043,
-0.065300815,
0.009219097,
0.015921447,
-0.015288897,
0.011056187,
0.0016621292,
-0.029985618,
-0.0019212059,
0.011345546,
0.01958217,
-0.009589206,
0.0043807533,
0.01065916,
-0.011809865,
-0.013579662,
-0.007893431,
0.02866668,
-0.0043067313,
0.020901106,
0.038895167,
-0.033969343,
-0.011823324,
0.0071935873,
0.01966292,
0.0039669033,
0.018317066,
-0.00528584,
0.017025048,
-0.024790622,
0.0011229466,
0.013734436,
-0.015302355,
-0.0071195653,
-0.015248521,
-0.0075906143,
-0.012267455,
-0.01553115,
0.029124271,
0.010988894,
0.013007674,
-0.030900797,
-0.041586876,
-0.004081301,
-0.010302509,
0.0024006662,
0.004468234,
-0.027415037,
0.020174345,
-0.018693905,
0.012987487,
0.004374024,
0.0033562223,
0.001438381,
-0.02160095,
0.0047037583,
0.006460097,
0.008781695,
0.0033208937,
-0.0053430386,
-0.017119257,
0.014185296,
0.039541177,
0.040940866,
0.012805796,
0.0086740265,
-0.020147428,
-0.020416599,
-0.002923867,
-0.00055768806,
-0.05146544,
-0.009844919,
0.0200263,
-0.0056660436,
0.02491175,
-0.00016644424,
0.010692807,
0.007563697,
0.00052320055,
-0.0200263,
0.018209398,
-0.010995624,
0.003130792,
-0.0052959337,
0.005386779,
0.033484835,
-0.007563697,
-0.010921601,
0.022839135,
-0.013943043,
-0.010100631,
-0.009104699,
0.02076652,
-0.014158379,
-0.0073752776,
-0.0027371296,
0.025288587,
0.014104545,
0.00024351537,
0.012381853,
0.0044884216,
-0.015598442,
-0.0069782506,
-0.013014404,
-0.0035160424,
-0.008788424,
0.016648209,
-0.019730214,
-0.03612271,
-0.021923954,
0.00195317,
-0.018895784,
0.0005400237,
-0.0046263714,
0.008445231,
-0.007987641,
0.0019363468,
-0.0072743385,
0.001130517,
-0.012765421,
0.037630066,
0.019339915,
0.023471685,
-0.0016225947,
-0.004037561,
0.001162481,
0.015638819,
0.008579817,
-0.04107545,
0.008566358,
-0.019353375,
-0.0018118554,
0.009434434,
-0.024494534,
-0.020564642,
-0.0015325907,
0.013552745,
0.03806074,
-0.0005854463,
-0.011749301,
0.092810065,
0.007456029,
-0.011473401,
0.019353375,
-0.023969652,
0.007846327,
0.018855408,
0.04145229,
0.0044446816,
-0.034130845,
0.010356343,
0.015127394,
0.008923009,
-0.02187012,
-0.015867613,
0.033511754,
-0.02683632,
0.015154311,
-0.012079036,
-0.020779978,
0.024117695,
0.013862291,
0.0041485936,
0.0076848236,
-0.03407701,
-0.010787017,
0.03509986,
0.017240385,
0.017401887,
-0.040375605,
0.001746245,
0.002155048,
-0.032219734,
-0.028128339,
0.0069782506,
-0.01001988,
-0.009434434,
-0.0054136957,
0.017536473,
0.015221604,
0.011628175,
0.012583731,
-0.016392495,
-0.030120203,
0.021264486,
0.0064432737,
-0.024400325,
0.017348053,
-0.012610648
] |
From April 1986 to September 2000, 122 MRCC patients were treated by monthly intralymphatic injections (containing a mean of 573 IL-2 U and 26 x 10(6) LAK cells) and i.m. administration of IFN and TF; 71 patients also received a 3-day cycle of monthly IL-2 inhalations with a mean of 998 daily U. MRCC cases not treated by immunotherapy (n = 89) represent our historical controls. Adverse clinical side effects related to treatment were negligible. CR (n = 11) and PR (n | [
-0.02595591,
0.0045028264,
0.0060413475,
-0.01129354,
0.0016338496,
-0.0040087756,
-0.014019109,
-0.011512381,
-0.01180417,
0.010053439,
0.0077124997,
0.014456792,
0.01423132,
0.00069797126,
0.0084883915,
0.007036081,
0.029974634,
0.008853127,
0.010550805,
-0.006701187,
-0.012314799,
0.0110813305,
-0.023236973,
-0.023939917,
-0.00890618,
0.0023127552,
0.006949871,
-0.039471023,
0.013031008,
-0.0011074699,
0.0028880427,
-0.017082889,
0.012507115,
-0.008117025,
-0.02659254,
-0.0043403534,
0.021313822,
-0.017679729,
0.009476493,
-0.012858587,
0.036447033,
0.0184092,
0.0128121665,
0.0087669175,
0.0060745054,
0.0061441367,
0.02424497,
-0.016897205,
-0.011691433,
0.008859759,
0.021658663,
-0.003256094,
-0.017560361,
-0.00008108113,
-0.006250242,
-0.0036871452,
-0.0066083455,
0.012991218,
0.0035777246,
-0.03191105,
-0.014098688,
-0.006651451,
-0.029497162,
0.0102258595,
-0.019934457,
0.019284565,
0.0045061423,
0.01329627,
0.00073817506,
0.008972495,
0.015690261,
0.051248666,
-0.010590595,
-0.008601128,
0.012202063,
-0.019470248,
0.0037899343,
0.0072814487,
0.008004288,
0.0019065724,
0.019616142,
-0.0001341854,
-0.014111951,
0.011691433,
0.010391648,
0.00013325283,
0.007394185,
0.005527402,
-0.029523687,
0.0037435135,
0.009721861,
0.025677385,
0.009403546,
0.011645013,
0.015756577,
0.014045635,
-0.009284179,
0.041062593,
0.01875404,
-0.020982243,
-0.013647743,
0.0018120727,
-0.010716595,
-0.021287294,
-0.041433964,
-0.00750029,
0.022321818,
0.008468497,
0.028038219,
-0.017056363,
-0.007865026,
0.04180533,
0.021088349,
-0.018700987,
0.0151066845,
-0.00014309655,
0.0038197762,
-0.020809824,
0.006976397,
-0.010378385,
0.004297248,
0.0030455422,
0.012387747,
0.00406846,
0.019921195,
0.0005628533,
-0.03191105,
-0.022653395,
-0.011472592,
0.023236973,
0.00089111534,
0.000941681,
0.022348344,
0.0102125965,
0.00639282,
0.035041142,
-0.018727515,
0.009489757,
-0.0039756177,
0.0020226245,
0.0044398266,
0.028780954,
0.012042906,
0.00024640377,
-0.013820163,
0.011857222,
0.026738433,
0.0015061921,
-0.008945969,
-0.022507502,
-0.004181196,
-0.03443104,
0.008441971,
-0.00004548833,
0.005530718,
0.000084811385,
-0.0142578455,
0.023913391,
-0.03140705,
-0.0067310296,
-0.013123849,
0.009012285,
0.010756384,
0.015544367,
0.020730244,
0.017918464,
0.018422462,
-0.01500058,
0.0029162269,
0.02075677,
0.024642862,
0.035943035,
-0.005245561,
0.016764574,
-0.019655932,
0.013899742,
-0.012149011,
-0.010133018,
-0.028489165,
-0.021300558,
-0.027348537,
0.018316358,
0.011194066,
-0.0073079746,
-0.026910855,
-0.011883749,
-0.0068901866,
-0.020398667,
-0.0075400793,
0.0031383839,
-0.0038794603,
0.012971324,
0.00023210446,
-0.031300943,
-0.6391759,
-0.017202256,
0.02915232,
0.014562897,
0.022746237,
0.015584157,
-0.014284371,
-0.019589616,
-0.030956104,
0.004015407,
0.0051593506,
0.018037833,
0.016910467,
-0.012029642,
-0.00026236093,
-0.03230894,
-0.013176902,
-0.0023508866,
-0.0074472376,
-0.008130288,
-0.029391056,
0.011903643,
-0.016287101,
0.02693738,
-0.01397932,
-0.019828353,
0.029178847,
-0.0072416593,
-0.011061436,
0.0136610055,
0.003209673,
-0.00093753624,
0.021008769,
-0.023873601,
0.044988476,
-0.008660812,
-0.018820357,
0.007513553,
0.010829331,
0.033953566,
-0.02693738,
-0.0022480974,
0.036500085,
0.00013086961,
-0.031141788,
0.037534606,
-0.006896818,
0.009708598,
0.016724784,
-0.0102192275,
0.015358684,
0.0045094583,
-0.030239895,
0.001926467,
0.026725171,
0.0025763595,
-0.0001565669,
0.01099512,
-0.0013602979,
-0.017586887,
0.0016239022,
0.015464788,
-0.011731222,
0.0071090283,
0.00513614,
-0.007732394,
-0.0020292562,
-0.0070891334,
0.023595076,
0.004320459,
0.027985167,
0.035863455,
0.0018999408,
-0.010378385,
0.010126386,
0.0021386768,
-0.0016056655,
0.0011887064,
-0.016035102,
0.0128121665,
-0.023674656,
-0.009396915,
-0.018475516,
0.008886285,
0.018886672,
-0.0075069214,
-0.017719518,
0.00226965,
0.00797113,
0.003690461,
-0.0017092836,
0.012407641,
0.008727128,
-0.0319641,
-0.015716787,
0.014151741,
0.021340348,
0.0113664875,
0.017255308,
-0.029178847,
0.0032046994,
-0.03111526,
0.03724282,
-0.003690461,
0.019456984,
-0.013521743,
-0.05315855,
0.0026476488,
0.019669196,
-0.025252966,
-0.0027388327,
-0.0051062983,
0.006346399,
0.0048012463,
0.044404898,
-0.0053218235,
-0.010709963,
0.018037833,
-0.010265648,
-0.020862876,
0.027799483,
-0.018077621,
0.028701374,
-0.0042209853,
-0.014297634,
-0.007997656,
0.0018054411,
-0.013163638,
0.005318508,
-0.00066895824,
0.024099074,
0.00042151829,
0.03779987,
-0.034510616,
0.032070205,
-0.001434074,
0.045572054,
-0.01917846,
0.0036108822,
-0.03493504,
-0.038967025,
0.008680707,
0.019748773,
0.012633114,
0.017905202,
-0.016180996,
0.017374678,
-0.0032229363,
0.0046984577,
-0.011910275,
0.012493852,
-0.020518035,
0.014165004,
0.021061823,
0.00421767,
-0.010358491,
0.0054411916,
-0.031433575,
-0.007049344,
-0.028144324,
-0.0003253607,
0.0073278695,
-0.016340153,
0.0022497554,
0.002689096,
-0.004283985,
-0.000768846,
0.029231898,
0.003464988,
-0.030956104,
-0.0026078594,
-0.008262919,
-0.0033423041,
0.023648128,
-0.0074472376,
0.0036937767,
-0.0023492288,
-0.019032566,
0.0053848233,
-0.01806436,
-0.003932513,
0.016698258,
0.024231706,
-0.005676612,
0.00096406246,
0.007049344,
0.04111565,
-0.016141208,
-0.008859759,
0.03772029,
-0.036393978,
0.0016098103,
-0.01619426,
0.023595076,
0.019430459,
-0.009430072,
0.0017988096,
-0.016127944,
0.01773278,
0.015239316,
0.009648914,
0.0055738227,
0.03429841,
-0.022494238,
0.0030157,
-0.03588998,
0.004555879,
-0.011114488,
0.04777373,
-0.0003798638,
0.00008766088,
0.019629406,
-0.010239122,
0.0020624138,
-0.018263305,
0.018700987,
0.0028963322,
-0.006896818,
-0.010000386,
-0.002405597,
-0.00588219,
0.0066282405,
0.014390477,
0.008335866,
0.015716787,
-0.0054610865,
0.014841422,
0.00045177474,
0.01009986,
-0.017082889,
-0.02480202,
0.019430459,
0.006515504,
0.017759306,
0.0056931907,
0.017878676,
-0.002360834,
-0.016326891,
0.033608727,
0.012248484,
0.0167911,
-0.0025017546,
0.021897398,
0.0046918257,
0.017255308,
-0.006767503,
0.017785834,
-0.0079180775,
-0.020677192,
0.00038877496,
-0.012653009,
0.008508286,
-0.010822699,
-0.018555094,
-0.013309533,
-0.0038595656,
0.0021884134,
0.0047581415,
0.050479405,
0.028913584,
0.0106967,
-0.006303294,
0.04031986,
-0.027242431,
0.0008869706,
0.015371947,
-0.0011746144,
-0.016061628,
-0.0071753436,
0.0015236,
-0.014456792,
0.009390283,
0.025067281,
-0.01210259,
0.02058435,
0.012838692,
0.018502042,
-0.0099340705,
0.008647549,
0.0105110165,
-0.023422657,
-0.032229364,
0.016379943,
0.013899742,
0.007135554,
-0.004715036,
-0.026725171,
-0.0006648135,
-0.021632135,
-0.0029941476,
0.0024453863,
0.019231513,
0.0040253545,
0.007732394,
0.014337424,
-0.014310898,
0.008063972,
-0.008189972,
-0.011041541,
-0.011479223,
-0.00958923,
-0.0011248777,
0.013886479,
0.006883555,
0.017639939,
-0.0022165976,
-0.0167911,
-0.0363144,
-0.021671925,
0.0042508272,
0.009277547,
-0.014098688,
-0.008594496,
0.004913983,
0.023475708,
0.012772377,
0.010444701,
0.006664714,
-0.0029775687,
-0.029603265,
-0.010325333,
-0.024046022,
-0.008747023,
-0.0056434544,
0.038807865,
0.022467712,
0.00519914,
0.0033986724,
-0.0005317679,
0.009622388,
-0.006137505,
-0.017149204,
0.017931728,
-0.015650472,
-0.00081899716,
0.024894862,
0.0048443517,
0.010895646,
0.013846689,
0.011704696,
-0.012599956,
-0.030107263,
-0.010829331,
0.008521549,
0.012825429,
-0.0024404125,
0.03989544,
0.039232284,
0.020876138,
-0.011731222,
0.01981509,
0.018647935,
0.019324355,
-0.020146668,
0.010763016,
0.01478837,
0.0077257627,
0.020491509,
-0.006571872,
-0.026062015,
0.0065751877,
-0.00006647099,
0.005510823,
-0.0107961735,
0.016950257,
0.011810801,
0.011127751,
0.0058291377,
0.027587272,
-0.0053914553,
-0.013117217,
0.009125021,
0.00023210446,
-0.005212403,
0.035836928,
-0.0032875938,
-0.0044464585,
-0.01120733,
-0.005706454,
0.016167734,
-0.008289445,
-0.0211414,
-0.01419153,
0.007752289,
-0.016963521,
-0.0439009,
0.005825822,
-0.011916907,
-0.04061165,
-0.014045635,
0.0019695722,
-0.0032627257,
-0.011452697,
-0.03119484,
-0.0050134566,
-0.0036705662,
0.0008082209,
0.031088734,
0.012679535,
0.0064259777,
0.0076528154,
-0.0018916513,
-0.003982249,
0.012016379,
-0.014045635,
0.010298806,
0.004081723,
-0.027295485,
-0.0013528374,
0.01879383,
0.01598205,
0.0046653,
-0.030080738,
-0.006154084,
0.0046056155,
-0.018117411,
0.007228396,
-0.01781236,
-0.010703332,
-0.00014081695,
0.0056931907,
0.021061823,
-0.031778418,
-0.014934264,
-0.009834598,
-0.021831082,
-0.042097118,
-0.0058324537,
-0.016313627,
0.009595862,
0.002732201,
0.023316551,
-0.018263305,
0.0057263486,
0.008926074,
-0.023794023,
-0.012221958,
-0.00015843201,
0.013243217,
0.029682845,
-0.009337231,
-0.012248484,
0.023382867,
-0.012686167,
-0.000036059086,
-0.0055240863,
0.015676998,
-0.006704503,
-0.019854879,
-0.012168906,
-0.022786027,
0.0013578112,
-0.041699223,
-0.0130906915,
-0.010835962,
0.02689759,
-0.014350687,
-0.006528767,
-0.04482932,
-0.04459058,
-0.017414466,
0.022215713,
0.008806706,
-0.040505543,
-0.024457179,
0.02356855,
-0.020279298,
0.0005918664,
0.013528374,
-0.018899934,
0.011651644,
0.023581814,
0.009456599,
0.0007705039,
-0.013687531,
-0.0066846083,
-0.025266228,
0.009430072,
-0.014589423,
-0.01103491,
0.014761844,
-0.013475322,
0.052415818,
0.026698645,
0.03835692,
-0.027162854,
-0.011638381,
-0.00274878,
0.014602686,
0.01742773,
0.017401204,
0.009953965,
-0.013130481,
0.006183926,
0.0065519772,
-0.008793443,
0.016472785,
-0.025717175,
0.005030035,
0.013137112,
-0.014098688,
-0.004380143,
-0.009052074,
-0.008335866,
-0.027799483,
0.017440991,
0.012606588,
-0.0045890366,
-0.014708791,
-0.0011397987,
0.025690649,
-0.004376827,
-0.0011281935,
-0.0035909875,
0.020212984,
-0.02041193,
-0.0125203775,
-0.018820357,
-0.0040717754,
0.003181489,
0.0071023963,
-0.0145363705,
-0.023449183,
-0.0035346195,
0.012765746,
-0.00046503785,
0.02817085,
-0.018714251,
0.00641603,
-0.020451719,
-0.050346773,
-0.01896625,
-0.017891938,
-0.010862489,
-0.015066896,
-0.011240488,
-0.00049197854,
-0.0009242731,
0.0019679142,
0.014735318,
0.010133018,
0.023595076,
-0.022003504,
-0.0057595065,
0.03456367,
-0.03806513,
0.022839079,
-0.022613605,
0.019204985,
0.03371483,
0.0039656707,
-0.01683089,
-0.026738433,
-0.0065088724,
-0.0046818787,
0.026274225,
0.05016109,
-0.004675247,
0.000009642956,
0.004333722,
0.0009615756,
-0.004151354,
-0.041248277,
0.013481953,
0.028966637,
0.0025133598,
-0.021499505,
-0.03716324,
-0.020292562,
0.02936453,
0.0025647543,
-0.0009599177,
-0.018143937,
0.013196796,
-0.026008964,
0.018183727,
-0.011618487,
-0.0024735704,
-0.02566412,
-0.0022182555,
-0.011916907,
-0.023051288,
-0.016035102,
-0.005948506,
-0.009469862,
0.03814471,
0.01990793,
0.00675424,
-0.008375655,
0.0023293342,
-0.015332158,
-0.0084950235,
-0.030346,
0.041487016,
0.000042975593,
0.0067708185,
-0.009118389,
-0.0022298608,
0.0041414066,
-0.019059092,
-0.0049703512,
0.0061474526,
-0.024523495,
0.011969958,
0.0276138,
0.018807093,
-0.029125795,
0.0036539873,
-0.016897205,
-0.0066945557,
-0.009396915,
-0.02944411,
0.023343077,
-0.04047902,
0.022427922,
-0.0060314,
0.0073411325,
0.011346593,
-0.01176438,
-0.001462258,
0.0014896133,
0.018196989,
-0.044166163,
0.0021602295,
0.025902858,
0.0079180775,
-0.0113731185,
0.0013213375,
-0.0060115056,
-0.0243776,
0.006780766,
0.008289445,
-0.045545526,
-0.026393592,
-0.007321238,
-0.011253751,
0.017069625,
-0.025597807,
0.024629598,
0.017003309,
-0.0021602295,
-0.009562704,
-0.024231706,
0.03716324,
-0.020358877,
0.0013486927,
0.018117411,
0.00030256473,
0.012865218,
-0.008999022,
0.018860145,
0.031566206,
0.00468851,
0.010073334,
-0.00006372511,
0.0007083331,
-0.013793636,
0.007095765,
-0.012984587,
-0.0064723985,
-0.025823278,
0.014934264,
0.0022132818,
-0.013926268,
-0.00379325,
-0.003988881,
-0.0069366074,
0.020849612,
-0.018594883,
0.0104977535,
0.0055738227,
-0.011154277,
-0.025213176,
-0.009748387,
-0.015862683,
0.041752275,
-0.0015890866,
0.015491315,
-0.021884134,
-0.028754426,
-0.0433969,
-0.017613413,
0.009118389,
0.016658468,
-0.010239122,
0.013528374,
-0.012984587,
0.007347764,
-0.006677977,
0.016698258,
-0.0016935336,
-0.018276569,
0.020624138,
0.0033423041,
0.013727321,
-0.0040220385,
-0.03323736,
-0.004960404,
0.015743313,
0.009622388,
-0.0034616722,
0.013236586,
-0.02054456,
0.0068371342,
-0.0077920784,
-0.016220786,
-0.034377985,
-0.00011252922,
-0.021605609,
-0.0022315185,
-0.006870292,
0.020000773,
-0.016379943,
0.009993755,
-0.014138478,
0.0064723985,
0.019655932,
-0.012891745,
-0.00022422949,
-0.012394378,
0.0012459035,
-0.030584736,
0.014085425,
0.019019302,
0.0012599956,
-0.00579598,
0.002838306,
0.0055605597,
0.0031151734,
-0.007135554,
0.0068636606,
-0.007858394,
0.012580061,
0.008561339,
-0.008753654,
0.028144324,
0.019019302,
0.00031230485,
-0.009854492,
0.0031897784,
0.0032527782,
-0.011843959,
0.01376711,
-0.0011563776,
-0.03870176,
-0.00903218,
-0.0053218235,
-0.019828353,
-0.014894475,
0.000099836005,
-0.0074406057,
-0.035226826,
-0.011041541,
0.004078407,
-0.0142578455,
-0.008587865,
-0.0038628813,
-0.01359469,
0.008110393,
0.01777257,
0.18547136,
-0.021247506,
-0.00809713,
0.02424497,
-0.016101418,
-0.013110586,
0.02634054,
0.009569336,
-0.0004841036,
0.0324681,
0.03167231,
-0.013402374,
0.0002254729,
0.0025531491,
0.0035346195,
-0.00830934,
-0.008985759,
-0.016353417,
-0.012135748,
0.008170077,
-0.015411736,
0.021711715,
0.024178654,
-0.0025647543,
0.01278564,
-0.013077429,
-0.030133791,
0.012042906,
0.025120335,
0.0061308737,
-0.02054456,
0.010882383,
-0.01163175,
0.004065144,
-0.0038065133,
0.003464988,
-0.010491122,
-0.026168121,
-0.0041579856,
-0.010345227,
-0.0106967,
-0.0014606002,
-0.021579083,
0.0018468883,
-0.005530718,
0.017719518,
-0.00058523484,
-0.020266036,
-0.012175537,
-0.019098882,
-0.037905972,
-0.0014879553,
0.0017009941,
0.029682845,
0.021632135,
-0.0068901866,
0.032202836,
0.0054113497,
-0.018555094,
-0.007049344,
-0.018767303,
0.0022547292,
-0.032415047,
0.01513321,
-0.023488972,
0.040346388,
0.0033224095,
0.0011397987,
-0.01419153,
-0.0062635047,
0.012175537,
0.0028764375,
-0.03090305,
0.0013031007,
-0.011817433,
-0.0007991025,
0.028621797,
0.03244157,
0.005928611,
0.017295098,
0.010007018,
0.0054743495,
0.004565826,
-0.015584157,
-0.018342884,
-0.015955525,
-0.00543456,
0.010557437,
-0.023170657,
-0.000642432,
0.00950302,
-0.0045359842,
0.0026924117,
-0.0037700396,
0.030399052,
-0.013621216,
0.006154084,
-0.009191337,
-0.005749559,
-0.0046686153,
-0.024457179,
0.064511776,
0.00997386,
0.004416616,
0.00075516844,
0.013753847,
-0.008249655,
-0.015438262,
-0.002853227,
0.004167933,
0.025491701,
-0.036234822,
0.02451023,
-0.006170663,
0.016804364,
-0.010491122,
0.0067741345,
-0.03851608,
0.013966057,
0.0054776655,
0.0065387143,
-0.02079656,
0.015849419,
0.012023011,
-0.025080545,
-0.007838499,
-0.030107263,
-0.003151647,
0.01197659,
-0.030505158,
-0.0042607747,
-0.003002437,
0.006810608,
-0.002299492,
0.016432995,
-0.0023409394,
0.0052754027,
-0.020226246,
-0.0110813305,
-0.017082889,
0.015955525,
-0.0058026114,
0.0008119511,
0.0076262895,
0.0019314407,
0.010126386,
0.019337617,
0.044272266,
-0.01836941,
-0.011883749,
-0.014324161,
-0.026406856,
-0.020425193,
0.00046545235,
0.034510616,
-0.03119484,
-0.032574203,
-0.020000773,
0.0025050703,
0.013647743,
-0.038675234,
-0.01265964,
0.015080159,
-0.0005640967,
-0.036208294,
0.00059352425,
-0.1667969,
0.0077589205,
0.015995312,
-0.007016186,
0.04326427,
0.003998828,
0.00030857458,
-0.010935436,
-0.010093228,
0.015464788,
0.015371947,
0.024072548,
-0.02539886,
0.003242831,
0.0007974446,
0.015676998,
-0.015783103,
0.05655391,
0.035916507,
-0.0012608246,
0.03610219,
-0.015212789,
0.0045459317,
-0.014735318,
0.00018557995,
0.0010875752,
-0.013561532,
-0.018223517,
0.005165982,
-0.0276138,
-0.013316165,
-0.0034417775,
0.032812938,
-0.025080545,
0.031221366,
-0.000987273,
0.02054456,
0.026115067,
-0.0015177974,
0.020173194,
0.028621797,
0.021167926,
0.0055738227,
0.021526031,
-0.04283985,
0.01935088,
0.008554707,
-0.005912032,
-0.006336452,
0.008614391,
0.013123849,
-0.021366874,
-0.005335087,
0.0007692605,
0.01133333,
0.019801827,
0.013939531,
0.0013951136,
0.012427536,
-0.0071421857,
-0.023754233,
-0.012984587,
0.024908124,
-0.033343464,
0.012255115,
-0.04024028,
0.013203428,
0.020663928,
0.0047912993,
0.013442164,
-0.014456792,
-0.010464596,
0.018250043,
-0.0064060832,
0.014019109,
-0.00031872917,
0.013037639,
-0.00047332732,
0.024894862,
0.0025465174,
-0.0077920784,
0.046606574,
0.005865611,
0.022282029,
-0.0039623547,
0.0026393593,
0.018488778,
0.031009156,
0.0020458351,
-0.020252772,
0.005099667,
-0.022693185,
0.003002437,
-0.015849419,
-0.0014713765,
0.0259957,
-0.0136610055,
0.018674461,
0.0056799278,
-0.020398667,
-0.000597669,
-0.01423132,
-0.019868141,
-0.008687339,
0.007573237,
-0.020279298,
-0.02480202,
0.016008576,
0.02416539,
-0.021897398,
-0.0013685874,
0.01090891,
0.0037600922,
0.014443529,
-0.006883555,
0.02037214,
-0.004346985,
-0.0044133007,
0.0036042507,
-0.008382287,
0.051620033,
0.0036274611,
-0.0034417775,
-0.008004288,
-0.018833619,
0.01513321,
-0.12849303,
0.0017192309,
0.03596956,
0.0024238338,
-0.0028167535,
0.038277343,
-0.012672904,
0.0006382873,
-0.02451023,
0.02809127,
-0.0019281249,
0.004018723,
-0.007135554,
0.009396915,
0.008753654,
0.0019546512,
0.03098263,
-0.049418356,
-0.004197775,
0.027136328,
0.010683437,
0.005331771,
-0.034537144,
-0.018873408,
0.00073817506,
-0.0050598774,
-0.027719904,
0.01615447,
0.023595076,
0.020690454,
0.02195045,
-0.011830696,
0.020862876,
-0.006047979,
-0.0067708185,
0.028117798,
-0.0422828,
-0.025067281,
0.024563283,
-0.02041193,
-0.003151647,
0.011598592,
0.012719325,
-0.0184092,
0.021048559,
0.0006988002,
-0.035253353,
-0.0125270095,
0.021910662,
-0.017069625,
-0.014456792,
-0.034749355,
-0.02480202,
0.009562704,
0.015199526,
-0.007984393,
0.010192702,
0.03299862,
-0.025451912,
-0.0119500635,
-0.008342497,
-0.009045443,
-0.025916122,
0.01862141,
0.02726896,
-0.0058589797,
0.0063696094,
-0.009622388,
0.0197753,
-0.014509845,
-0.025531491,
-0.0036506716,
-0.02714959,
-0.016074892,
-0.020677192,
-0.01086912,
-0.015239316,
-0.035783876,
0.00058440585,
-0.0319641,
-0.014417003,
-0.0052754027,
0.011253751,
0.0012566799,
0.027879061,
0.00490072,
0.017122678,
-0.007420711,
-0.006896818,
0.013302902,
-0.004778036,
0.023343077,
-0.0128055345,
-0.013455427,
-0.002776964,
0.03596956,
-0.01598205,
-0.016472785,
0.037905972,
0.044219214,
-0.0033290412,
-0.033529148,
-0.060745053,
0.024656124,
-0.0030190158,
0.000087505454,
0.015703525,
-0.02970937,
0.017852148,
-0.011048173,
0.015027106,
-0.0026377013,
-0.023939917,
0.010849225,
-0.016180996,
0.027481169,
-0.008800074,
-0.01555763,
-0.0012318115,
-0.009708598,
0.020332351,
0.020823086,
-0.0008239708,
-0.0016860731,
0.0015211132,
0.017056363,
0.0036274611,
-0.0045326687,
0.011578697,
0.06318547,
-0.02037214,
-0.0034583565,
-0.0021602295,
-0.026327277,
-0.011485855,
0.010438069,
-0.004051881,
-0.016035102,
0.0030190158,
0.04952446,
0.0020707033,
0.007957867,
-0.016101418,
-0.0368184,
0.035147246,
0.0028863847,
-0.016207524,
0.0018170463,
-0.0142445825,
0.016220786,
-0.021499505,
-0.0014009163,
0.0054610865,
-0.009091863,
-0.00203423,
-0.04031986,
0.00016216227,
0.014178267,
0.012149011,
-0.020398667,
-0.0032345415,
-0.014748581,
0.027719904,
0.013873215,
-0.006747608,
-0.005464402,
0.022401396,
-0.006286715,
-0.015491315,
0.00564677,
0.003899355,
0.00050731405,
-0.0035810403,
0.01500058,
-0.0042939326,
0.014854685,
0.0073543955,
0.015159737,
0.0065652407,
0.027799483,
0.0010428121,
-0.0048609306,
-0.010915541,
-0.023276761,
-0.03323736,
0.001478837,
0.00045799185,
0.009270916,
-0.017838886,
0.033316936,
-0.0033124622,
-0.0064558196,
0.016472785,
0.013647743,
0.0032875938,
-0.017494045,
0.015424999,
0.038967025,
0.021565821,
-0.010033544,
0.0042740377,
0.033449568,
0.0133824805,
0.0044133007,
-0.015279105,
-0.03785292,
-0.015345421,
-0.009416809,
-0.028860532,
-0.024788756,
-0.019456984,
0.0032444887,
0.009635651,
0.01892646,
0.008634286,
0.013183533,
-0.022825817,
-0.01781236,
-0.008289445,
-0.0068437657,
0.00579598,
0.041327856,
-0.009005653,
0.02143319,
0.016923731,
-0.0009599177,
-0.005202456,
0.009821335,
0.009715229,
-0.005345034,
0.016817626,
0.025969174,
-0.0130906915,
0.014642476,
-0.04082386,
-0.0151199475,
0.010139649,
-0.023767497,
-0.009270916,
0.0034550407,
0.00072325405,
0.074697845,
0.0044298796,
-0.03098263,
0.005185877,
-0.0059385584,
0.012772377,
0.01269943,
0.0031781732,
-0.0063861883,
-0.053689077,
0.005132824,
-0.0043270905,
0.04363564,
-0.04522721,
-0.0552276,
0.0011969958,
0.011651644,
0.01283206,
-0.01146596,
-0.01935088,
0.028250428,
-0.0061772945,
0.0082164975,
-0.010889015,
-0.016910467,
0.005093035,
0.016048366,
-0.025836542,
-0.008581233,
-0.028542217,
0.000336137,
-0.0014357319,
-0.033210833,
-0.022812553,
0.015690261,
-0.019934457,
-0.006047979,
-0.02838306,
0.022945184,
-0.00008077028,
-0.02659254,
0.041195225,
-0.02424497,
-0.011180803,
-0.006581819,
-0.017746044,
-0.01248722,
-0.01931109,
-0.02012014
] |
Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by two distinct lineages of CD4+ T cells that are defined by the production of either interferon-γ or interleukin-17. The activity of these CD4+ T cell subsets within the CNS influences the pathology and clinical course of disease. New animal models show that myelin-specific CD8+ T cells can also mediate CNS autoimmunity. This Review focuses on recent progress in delineating the pathogenic mechanisms, regulation and interplay between | [
-0.0194655,
0.019909382,
0.00042511427,
-0.03188112,
-0.012239374,
-0.0074415393,
-0.016240833,
-0.009249703,
-0.015862228,
-0.02352571,
0.0075525097,
0.019348003,
-0.010450793,
0.0007596571,
-0.012147986,
0.014595862,
0.042247057,
0.023630152,
-0.01848635,
-0.007023769,
-0.043395925,
0.01770303,
0.0135514345,
-0.008185693,
0.008002919,
0.01770303,
-0.009752333,
-0.054936837,
-0.018055525,
-0.008583881,
0.007611259,
-0.019622164,
-0.0054603927,
0.004360481,
0.023956535,
-0.030810583,
0.014700304,
-0.0005613793,
0.007683063,
0.01669777,
0.011854242,
0.025118459,
-0.008596936,
0.013747265,
0.01840802,
0.011717161,
-0.012624506,
-0.0044420767,
-0.011573552,
0.028382292,
0.040210422,
0.016658604,
-0.025405677,
0.0015715356,
-0.039244328,
-0.025549285,
-0.0014303748,
0.0068736323,
0.012800753,
-0.035588834,
0.0019289254,
-0.012696311,
-0.009941636,
-0.00018124473,
0.01127328,
0.007630842,
0.0048794304,
0.02318627,
-0.01454364,
-0.013042277,
0.03256,
0.02282072,
0.0006617422,
-0.0059010102,
0.017951082,
-0.010411628,
-0.0114234155,
-0.016854433,
-0.014621972,
0.0010672734,
0.024034867,
-0.04961026,
0.0046117962,
0.033761088,
0.0069519645,
-0.0059956615,
0.0018424338,
0.012715894,
0.008440272,
-0.0070041856,
0.0006376714,
0.001075433,
0.023238491,
0.018342743,
0.005274354,
0.025705948,
0.019282727,
0.028356181,
-0.03266444,
-0.0068018283,
-0.0030549478,
0.0068475218,
-0.010411628,
-0.024935685,
-0.028408403,
-0.0028003687,
0.006827939,
0.010137466,
0.021371579,
-0.007683063,
-0.019361058,
0.016554162,
-0.011168837,
-0.047782518,
0.012859502,
0.030027265,
0.0139300395,
-0.007448067,
-0.022925163,
0.0007898476,
0.008636102,
0.01829052,
0.015340015,
-0.013943095,
0.03767769,
0.019113006,
-0.01451753,
-0.0045595746,
-0.02869562,
-0.002284683,
-0.0054603927,
0.007931114,
0.004438813,
0.012461315,
0.00097915,
0.008270553,
-0.016384441,
0.0053102565,
-0.020575203,
-0.024739854,
0.0105748195,
0.036450487,
-0.0059010102,
0.0152094625,
0.008453327,
0.02480513,
0.023656262,
0.011416888,
0.0058748997,
0.0020578466,
-0.021528242,
-0.033969976,
0.017520256,
-0.008818877,
-0.002524575,
0.009739278,
0.000041511877,
0.04914027,
-0.032298893,
-0.017272204,
0.0063024615,
-0.011123143,
0.005039358,
0.0020692702,
0.0008355413,
0.0149744665,
-0.003772991,
0.027860079,
-0.009093039,
0.005571363,
-0.0053494223,
0.03689437,
0.00032373145,
0.017794417,
-0.026606767,
0.003965557,
0.0059467037,
0.018447185,
-0.015548901,
-0.015901394,
0.011782438,
0.014739471,
0.027207313,
-0.015105019,
0.0028313752,
0.007989863,
0.033969976,
-0.021280192,
-0.005845525,
-0.015313905,
-0.0023956534,
0.00125168,
-0.009412895,
-0.039766543,
-0.6258204,
-0.009301924,
0.02866951,
-0.0073370966,
-0.0014834121,
0.049323045,
-0.0083945785,
-0.0026681835,
-0.01971355,
0.018159967,
-0.004536728,
0.021828515,
0.021854626,
-0.016175557,
-0.025758171,
-0.03101947,
-0.0131010255,
-0.007898476,
0.013851708,
-0.0021949278,
0.035902165,
-0.0014336386,
0.0004769276,
0.01003955,
-0.006782245,
-0.0038578508,
-0.0019060785,
-0.018538572,
0.004128749,
0.035980497,
-0.009608724,
0.0149744665,
-0.018917177,
0.0054244907,
0.046476983,
0.011508276,
-0.017389702,
0.026084553,
0.0031381755,
0.039740432,
-0.021188805,
-0.0024495067,
-0.0016727145,
-0.01879968,
-0.0168936,
0.016436663,
-0.0017298316,
-0.004200553,
0.013890874,
-0.02416542,
0.034022197,
0.019321892,
-0.0058944826,
-0.006455862,
0.019282727,
-0.011345084,
0.01594056,
-0.00056994683,
0.015078909,
0.0049904007,
-0.0061294786,
0.017781362,
-0.0058194143,
-0.029687826,
-0.021711018,
-0.005555044,
-0.030915027,
-0.019648274,
0.0037403528,
0.00015921386,
0.019387169,
0.01745498,
-0.010933841,
-0.0077091735,
0.010535653,
0.026998427,
0.003361748,
-0.009582614,
-0.004396383,
0.00992858,
-0.016828323,
-0.013394771,
-0.00903429,
-0.00504915,
-0.007278348,
-0.03488385,
-0.0029896712,
0.016201667,
-0.010705372,
0.0121088205,
0.0148308575,
-0.0047031837,
-0.005254771,
-0.04592866,
-0.015849173,
0.034022197,
0.0007841359,
0.0020839574,
-0.0027448835,
0.0045889495,
0.016841378,
-0.009895942,
0.0034172332,
-0.0014018163,
0.01197174,
0.016736936,
-0.037103254,
0.01731137,
0.046868645,
-0.008792766,
0.009634836,
0.0019648275,
0.00062257616,
0.0027465154,
0.025027072,
-0.0087536005,
-0.0035608418,
0.018917177,
-0.0040047234,
-0.00023601593,
0.024544025,
-0.0023760705,
0.00140916,
0.0036228546,
0.009967746,
-0.0045791576,
0.0073566795,
-0.026789542,
0.0007853598,
-0.034361634,
-0.011286335,
-0.015340015,
0.0065603047,
-0.0024185004,
0.025692893,
0.0025637408,
0.03485774,
0.0023189534,
-0.0017053528,
-0.04005376,
-0.0403932,
-0.011025229,
-0.01227854,
-0.0112602245,
0.0016000941,
0.020627424,
-0.014008371,
0.009765388,
-0.008015974,
-0.004034098,
0.019269671,
0.0063612107,
-0.0033486928,
0.014086704,
0.033160545,
-0.004569366,
-0.011697577,
-0.0072391815,
0.006060938,
-0.01141036,
-0.014504475,
0.00939984,
0.013851708,
0.026658988,
-0.030210039,
-0.005604001,
0.0020823255,
0.023081828,
-0.007761395,
-0.046215877,
-0.008316247,
-0.01227854,
-0.024074033,
0.019648274,
0.012030489,
-0.0052645626,
-0.0027709943,
-0.012572285,
-0.005574627,
0.0033943865,
-0.008270553,
-0.0009481435,
0.018421074,
-0.027337866,
0.040497642,
-0.0004618324,
0.032742772,
-0.0040797913,
0.0016147814,
0.048148066,
-0.01376032,
0.028147297,
-0.030445036,
0.014243367,
-0.0015356335,
-0.022389894,
-0.0015111547,
0.013211996,
0.0062437127,
0.01169105,
-0.016541107,
-0.031097801,
0.0023972853,
-0.024309028,
0.024335138,
-0.023055717,
0.0063840575,
-0.021658797,
0.023669317,
0.004086319,
0.006524402,
-0.010535653,
-0.00002289783,
-0.0048239455,
0.019152172,
0.0019517721,
0.0028640134,
-0.0028281114,
0.01596667,
-0.02908728,
-0.009184427,
0.010633568,
0.016397497,
-0.024309028,
0.003753408,
0.040210422,
0.0026257536,
0.01765081,
-0.00051282975,
-0.016645549,
-0.006664747,
-0.008518605,
0.00816611,
0.016632494,
0.020261876,
0.011371194,
0.00089837005,
-0.005453865,
0.044153135,
-0.0066778027,
0.007741812,
0.012787698,
-0.015222518,
0.00920401,
0.0030467883,
-0.01306186,
0.02257267,
0.011482165,
-0.008485966,
0.029687826,
-0.033212766,
-0.010470376,
-0.01569251,
-0.011051339,
-0.009354145,
-0.00014677049,
0.008231387,
-0.0033682757,
0.038617674,
0.030941138,
0.039139885,
-0.031646125,
0.0005756586,
-0.0022830511,
-0.009987329,
0.0067365514,
-0.0062469766,
-0.0041940254,
-0.018368853,
-0.0025719004,
-0.03530162,
-0.004902277,
0.02754675,
-0.024648467,
0.021998234,
0.028800063,
0.00023683188,
0.008472911,
0.019517722,
0.017885806,
-0.02103214,
-0.014752526,
0.02022271,
0.010163576,
-0.0025474217,
0.004925124,
-0.0149353,
-0.0007878077,
0.000019302513,
-0.0049283877,
0.00387417,
0.024726799,
-0.007291403,
0.014739471,
-0.020940753,
-0.012722421,
0.031097801,
-0.007722229,
0.001116231,
-0.015979726,
0.0014687249,
-0.0106662065,
-0.020823255,
0.010503015,
0.008146527,
0.016958877,
-0.008414161,
-0.017415814,
-0.021502132,
-0.034309413,
0.020979919,
-0.019700496,
-0.008081251,
-0.02458319,
0.007630842,
-0.002367911,
0.013603657,
0.0040928465,
0.024426527,
0.002970088,
-0.009543448,
-0.028147297,
0.01868218,
-0.0029994627,
0.018747456,
0.0075525097,
-0.018329687,
0.021697963,
0.009445533,
-0.005274354,
-0.025000961,
-0.029740047,
0.0357455,
-0.024961796,
-0.018590793,
-0.00031169606,
0.00014921837,
0.017167762,
0.03470107,
0.030862806,
0.013851708,
-0.02103214,
-0.00992858,
-0.0026567602,
0.017415814,
-0.0035184121,
0.027259534,
0.010803288,
0.031620014,
-0.017546367,
0.00080412684,
0.034022197,
-0.015679454,
-0.035797723,
0.005140537,
0.036763817,
-0.0067496067,
0.0096740015,
-0.0064460705,
-0.032742772,
-0.004970818,
0.02100603,
0.011149254,
0.0015029951,
0.036450487,
0.023081828,
0.0093867835,
0.0028330071,
0.000024861229,
-0.014034483,
0.03464885,
0.018055525,
-0.0029651923,
-0.016436663,
0.0012614715,
-0.026006222,
0.004203817,
-0.014243367,
0.0023222172,
-0.017167762,
-0.016005838,
-0.006958492,
-0.005085052,
0.012859502,
0.004729294,
-0.013381716,
0.006041355,
-0.0029798795,
-0.033291098,
-0.0078070886,
0.003616327,
0.014047538,
-0.023003496,
-0.022324618,
0.015888339,
-0.03028837,
-0.02181546,
0.02413931,
0.020105211,
0.019791884,
0.024152365,
0.0033682757,
-0.013629767,
0.02634566,
-0.00457263,
-0.011456054,
-0.008283609,
-0.019517722,
0.020992974,
0.022977386,
0.022951273,
-0.014060593,
-0.009073456,
-0.0022455172,
-0.010274546,
-0.025484009,
0.0071673775,
0.020901587,
-0.008440272,
0.0050785244,
0.02531429,
0.0253404,
-0.005519142,
-0.025353456,
-0.030027265,
-0.013812542,
-0.012154514,
-0.019374114,
0.0046085324,
-0.035588834,
0.009863304,
0.011612718,
-0.0060348273,
-0.022755444,
0.004908805,
-0.0013602024,
0.009778444,
-0.0034074418,
0.009125677,
0.029975044,
0.0033519566,
0.023839036,
0.016240833,
-0.016018894,
-0.009412895,
-0.027233424,
0.020575203,
0.0034433438,
-0.024857353,
-0.0058357334,
0.0072522373,
-0.008812349,
-0.0069519645,
-0.017219983,
-0.011416888,
0.032768883,
-0.012095765,
-0.03618938,
-0.0040536807,
0.008002919,
-0.0032001883,
0.029818378,
0.0021117,
0.002911339,
-0.021906847,
0.0036424377,
-0.022729333,
-0.0020578466,
0.03258611,
-0.043448146,
0.004203817,
0.027572861,
0.0008820509,
0.030810583,
-0.0017053528,
-0.012063127,
-0.008942903,
0.0037795187,
-0.018355798,
-0.020183545,
0.014230312,
-0.022990441,
0.03488385,
0.03459663,
0.034466077,
-0.014883079,
-0.0013030854,
0.009882887,
0.009798027,
0.009360673,
-0.0013014534,
0.026815653,
-0.0025066237,
0.0011896671,
-0.00984372,
-0.012317706,
0.022846831,
-0.024204586,
0.003302999,
0.033708867,
-0.008107361,
-0.03733825,
-0.0148308575,
-0.02391737,
-0.0114234155,
0.052821875,
-0.016906654,
0.012800753,
-0.017154707,
0.0065015554,
0.023891259,
0.012141459,
0.015248628,
0.017964138,
0.0139300395,
-0.0033405332,
0.0030206775,
-0.01434781,
0.02139769,
-0.017624699,
-0.01669777,
-0.0006609262,
-0.0071021006,
0.019870216,
0.0010305553,
0.0050589414,
0.018368853,
0.015170296,
0.010992589,
0.015405292,
-0.012657145,
-0.01980494,
-0.03934877,
-0.023225436,
-0.024857353,
0.00040899907,
-0.017141651,
-0.02257267,
-0.0038643784,
-0.0013267482,
-0.01596667,
0.015875284,
-0.03765158,
-0.02242906,
0.0467642,
-0.0048794304,
0.020183545,
-0.02144991,
0.0006801012,
0.018146912,
-0.0038382676,
-0.015796952,
-0.015274739,
-0.0040373616,
-0.002407077,
0.021893792,
0.026058443,
0.00378931,
-0.016240833,
0.003245882,
0.0023989172,
0.017585533,
-0.038330454,
0.01434781,
0.014674193,
0.012206736,
-0.03765158,
-0.024609301,
-0.014426142,
0.027703416,
-0.01772914,
-0.012128403,
-0.0011480533,
-0.00855777,
-0.022246286,
0.035928275,
-0.022585725,
0.0060837846,
-0.01770303,
-0.016071115,
-0.004167915,
-0.01968744,
-0.009132205,
-0.0054440736,
-0.005019775,
0.033996087,
0.007944169,
0.0102876015,
0.005039358,
-0.0107380105,
0.0019468764,
0.0071477946,
-0.01275506,
0.04360481,
-0.01596667,
-0.0069911303,
0.017350536,
0.010613985,
0.010672734,
-0.013133665,
0.0026975581,
0.00026253457,
-0.016436663,
-0.0022128788,
0.033082213,
0.008420689,
-0.015235573,
0.007761395,
-0.024204586,
-0.006547249,
-0.02592789,
-0.015261684,
0.0036783398,
-0.023316823,
0.018081635,
0.004850056,
0.010888147,
0.01742887,
0.01848635,
0.014099759,
-0.0031903968,
0.02039243,
-0.028904505,
0.014452253,
0.012056599,
0.033264987,
-0.006158853,
0.00082982954,
-0.010424683,
-0.03148946,
0.004908805,
-0.0077091735,
-0.05256077,
-0.01356449,
0.012552702,
0.015535845,
0.008120417,
-0.020287987,
0.040549863,
0.015418347,
0.014491418,
0.0046836003,
-0.03342165,
0.013825597,
-0.012533119,
-0.0119456295,
0.014165035,
-0.0017233038,
-0.003170814,
0.00009092835,
0.0057312907,
0.01513113,
-0.0020790617,
-0.010659679,
-0.033630535,
0.007545982,
-0.009726223,
0.0035282036,
-0.005476712,
-0.0016792421,
-0.013629767,
0.011097033,
0.022416005,
-0.011697577,
-0.00866874,
0.0065341936,
0.018538572,
0.021632686,
-0.025914835,
-0.0029798795,
0.0077352845,
-0.032481667,
-0.033969976,
-0.02083631,
-0.019334948,
0.030445036,
0.00746765,
0.020131322,
-0.0077091735,
0.00076740875,
-0.038461007,
0.009308452,
0.0152094625,
0.0092235925,
0.005884691,
0.038696006,
-0.016749991,
-0.011044811,
-0.015039743,
0.016645549,
-0.006429751,
0.0012157778,
0.016541107,
0.0033405332,
0.018081635,
-0.0019827785,
-0.0056660143,
-0.015770841,
0.028773952,
-0.0066582193,
-0.005316784,
0.020105211,
-0.007193488,
0.015052798,
-0.0021117,
0.0054473374,
-0.027181203,
0.0034368162,
0.010326768,
-0.03107169,
0.0022471491,
0.006605998,
-0.017898861,
0.016815268,
-0.03334332,
0.015888339,
0.016449718,
0.0076047312,
-0.016632494,
-0.03537995,
0.021802405,
-0.021332413,
0.002074166,
0.02480513,
-0.015013632,
0.016710825,
-0.012480898,
-0.0015886708,
-0.009484699,
-0.015340015,
0.0023777024,
0.010202742,
-0.005316784,
-0.008969014,
-0.010757593,
0.024844298,
0.026332606,
-0.03927044,
0.005825942,
-0.00559421,
0.007761395,
-0.048565835,
0.016253889,
0.008786239,
-0.013048804,
0.0032181393,
-0.012591868,
-0.0045661023,
-0.028904505,
0.0009987329,
0.0044061746,
-0.012709366,
-0.0022145107,
0.001408344,
0.0031985564,
0.010072188,
-0.0048010983,
-0.0009089775,
-0.03543217,
-0.0006890768,
0.17870139,
-0.019791884,
-0.009660946,
-0.01745498,
-0.014674193,
-0.002738356,
0.0067365514,
-0.009621779,
-0.020483816,
0.009360673,
0.010894675,
-0.013251162,
0.005434282,
0.00598587,
0.011234113,
-0.015640289,
-0.023473488,
-0.017807472,
-0.00086002,
-0.018995509,
0.0008302375,
-0.0031414393,
0.011416888,
-0.005421227,
0.039505437,
0.014269479,
-0.016606383,
0.011527859,
0.026332606,
0.0135514345,
-0.033526093,
0.034335524,
0.0030321009,
0.0026388092,
0.0022112469,
0.011332029,
-0.020235766,
-0.0148308575,
0.014308644,
-0.0040210425,
-0.004804362,
-0.00007527215,
-0.015548901,
0.0056758057,
-0.00092203286,
0.023486543,
0.0014948356,
-0.018212188,
-0.010764121,
0.003851323,
-0.035562724,
-0.0070302966,
0.02041854,
0.0138386525,
0.025523175,
0.005923857,
0.03193334,
0.01107745,
0.005538725,
0.019426335,
-0.016031949,
-0.008296664,
-0.02436125,
0.03890489,
0.005721499,
0.018512461,
0.0002462154,
-0.0031512307,
0.013068387,
-0.013225052,
-0.0060511464,
0.008094306,
-0.017663864,
-0.008583881,
-0.001661291,
-0.0011056234,
0.01985716,
-0.007330569,
0.008322774,
0.004435549,
0.008440272,
0.027860079,
-0.019961603,
0.022611836,
0.0045040897,
-0.03613716,
0.02047076,
0.0020578466,
-0.02788619,
0.016214723,
-0.00003776357,
-0.0030076222,
0.0027546752,
0.00078291196,
-0.012572285,
-0.022337673,
0.0129378345,
-0.019426335,
0.007062935,
-0.032794993,
-0.041202627,
0.10318935,
0.01703721,
-0.0048598475,
-0.019204393,
0.022481281,
0.00527109,
-0.015457514,
-0.00051446166,
-0.0019713552,
0.0009473275,
-0.027964521,
0.014817802,
0.004869639,
-0.01745498,
0.017154707,
-0.022755444,
-0.021188805,
0.028042853,
0.004083055,
0.004105902,
-0.030157818,
-0.026763432,
0.0149353,
-0.0016204931,
0.009158315,
-0.03733825,
0.005254771,
-0.0018620167,
-0.021711018,
-0.013264217,
-0.03107169,
-0.0018473295,
0.03342165,
0.010979534,
-0.010999117,
0.014047538,
-0.008890681,
-0.026893985,
0.02629344,
-0.013512269,
-0.006730024,
0.012043544,
-0.003226299,
0.011932573,
-0.0018522253,
0.008172638,
0.041098185,
-0.024713743,
-0.014713359,
-0.020496871,
-0.016031949,
-0.007245709,
-0.005907538,
0.024413472,
-0.015170296,
-0.0011676362,
-0.01971355,
-0.010509542,
0.014491418,
-0.02827785,
0.009478171,
0.0016702666,
-0.007506816,
-0.0014360866,
-0.0076765353,
-0.1613639,
0.002521311,
0.005535461,
-0.0156664,
0.020979919,
0.015548901,
-0.0078527825,
0.0013642822,
-0.0075394544,
0.018564682,
0.048069734,
-0.01829052,
-0.02357793,
-0.011162309,
0.0188519,
-0.013903929,
-0.022128789,
0.048618056,
0.014843913,
0.011547442,
0.019609109,
-0.040288754,
-0.0014613812,
-0.01770303,
0.0014540376,
0.015340015,
-0.0031838692,
-0.014295589,
-0.011671467,
-0.019400224,
-0.019191338,
-0.022089623,
0.031254467,
0.010222325,
0.026202051,
-0.010326768,
-0.00024560344,
-0.02419153,
-0.0071216836,
0.039087664,
0.03263833,
0.0036097993,
0.018864956,
0.00785931,
-0.028225629,
0.022285452,
-0.00622413,
-0.022846831,
0.02005299,
-0.0055583077,
0.016958877,
0.0037011867,
0.009282341,
0.007565565,
0.03258611,
0.014948355,
0.0131010255,
0.011651884,
0.0125592295,
0.010561764,
0.0022716278,
-0.009876359,
0.020301042,
-0.0012524959,
0.011292863,
-0.020301042,
0.015340015,
0.004582422,
-0.010163576,
0.020731868,
-0.026410937,
-0.00570518,
0.010241908,
-0.020274932,
0.01451753,
0.005045886,
-0.016684715,
0.018499406,
0.000032434342,
0.002599643,
-0.003910072,
0.000995469,
-0.004967554,
-0.013982261,
-0.02282072,
-0.0025082557,
0.012526591,
0.03188112,
0.0025066237,
0.0056431675,
-0.0049120686,
-0.025875669,
-0.005036094,
-0.014282534,
0.006390585,
0.034257192,
0.00727182,
-0.009876359,
0.013721154,
0.008381523,
0.010189687,
-0.016645549,
-0.0286434,
-0.00805514,
-0.019060785,
-0.020601314,
-0.029661715,
-0.008877626,
0.007062935,
-0.0063285725,
0.007872365,
0.03660715,
0.015731676,
0.019400224,
-0.0048206816,
-0.005590946,
-0.0053820605,
0.004712975,
-0.0028509581,
-0.013022694,
0.064545564,
0.0031544946,
0.008831932,
0.005300465,
-0.014217257,
-0.026946206,
-0.13034444,
-0.045014787,
0.0016319165,
0.004367009,
-0.019178282,
0.01731137,
-0.009138732,
0.025588451,
-0.026463158,
-0.0067561343,
-0.011560497,
-0.00028823726,
-0.013107554,
-0.040758748,
0.00461506,
-0.005238452,
0.006661483,
-0.005297201,
-0.020731868,
0.025027072,
0.013192413,
-0.015901394,
-0.011462581,
-0.006393849,
0.0030435242,
0.004882694,
-0.029922822,
0.024060978,
0.00024111567,
0.0053820605,
-0.003557578,
-0.0014148717,
0.030967249,
-0.008440272,
-0.0027481474,
0.0074872333,
-0.00080698275,
-0.03263833,
0.03300388,
-0.011939101,
-0.0020986446,
0.018904122,
0.014465308,
-0.0049544987,
-0.007741812,
0.0047195028,
-0.039479326,
-0.015548901,
0.03483163,
-0.008949431,
-0.016593328,
-0.023003496,
-0.045275893,
-0.010202742,
-0.00039553578,
0.010901202,
-0.0015747994,
0.014582806,
-0.013407826,
-0.008577353,
0.034387745,
-0.01158008,
-0.005000192,
0.008309719,
0.033212766,
0.0012198576,
-0.011560497,
-0.018342743,
0.01966133,
-0.03940099,
-0.0028460624,
-0.03692048,
-0.007898476,
-0.01691971,
-0.010163576,
0.015340015,
-0.0007290587,
-0.029478941,
-0.0029407137,
-0.01208271,
-0.033160545,
-0.0048565837,
0.020914642,
0.018538572,
0.033108324,
0.0009563031,
0.012480898,
-0.0072065433,
-0.013120609,
-0.009452061,
-0.016984988,
0.038278233,
0.0053657414,
-0.00072783476,
0.0064003766,
0.010085244,
-0.00018359062,
-0.010372462,
0.009262758,
0.029844489,
-0.009060401,
-0.01826441,
-0.041724842,
0.0069846027,
-0.002049687,
-0.004083055,
0.002467458,
0.0051438008,
0.012546174,
-0.044100914,
0.012010906,
0.021280192,
-0.0077744504,
0.009765388,
-0.00055893144,
0.029687826,
-0.024687633,
-0.027050648,
0.027390087,
-0.016097225,
0.008851515,
0.023094883,
0.006025036,
-0.0037109782,
0.003381331,
0.021619631,
-0.0026045388,
0.0043898555,
-0.011939101,
0.026724266,
-0.012063127,
-0.0047031837,
0.0076765353,
-0.028852284,
-0.008433744,
0.0136950435,
-0.012624506,
-0.017716086,
0.00500672,
0.04279538,
-0.010653151,
0.046738088,
-0.019674385,
-0.032298893,
0.0034466076,
-0.01980494,
-0.020992974,
-0.020601314,
-0.06015897,
0.014295589,
0.0071021006,
-0.013159775,
0.042743158,
0.005803095,
-0.019374114,
-0.03767769,
-0.028930616,
0.027860079,
0.004902277,
-0.020562148,
-0.018199133,
-0.020679647,
0.007898476,
0.028826173,
0.014804747,
0.012493953,
0.015235573,
-0.022220176,
-0.037938796,
0.002694294,
0.0017428868,
0.0058194143,
-0.022481281,
0.034022197,
0.0045661023,
0.001192931,
0.009954691,
-0.002227566,
-0.001289214,
0.000068897476,
-0.022912107,
0.014373921,
-0.0028281114,
-0.01809469,
-0.027311755,
0.01879968,
0.029505052,
0.021567408,
-0.016619438,
0.0127028385,
-0.0032148755,
-0.029322276,
0.014204201,
0.012813808,
-0.0012533119,
0.030758362,
0.015992781,
0.014752526,
0.00250336,
0.011227585,
0.012154514,
0.049349155,
0.007010713,
-0.0018000039,
0.014582806,
-0.020744924,
0.006723496,
0.03193334,
-0.04979304,
-0.027363976,
-0.028121186,
-0.0012737109,
0.014086704,
0.023812925,
-0.003949238,
-0.0066582193,
-0.020457705,
0.016293054,
-0.012128403,
0.0043931194,
-0.024674578,
0.001876704,
0.021476021,
0.0037175058,
-0.0074350117,
-0.010254963,
-0.006276351,
0.0029276581,
0.015653344,
-0.021332413,
0.01770303,
0.011749799,
0.020718813,
-0.013603657,
-0.021959068,
0.010189687,
-0.019178282,
-0.0313328,
0.016567217,
0.015757786,
-0.004846792,
0.06882771,
-0.00042552224,
-0.011038284,
-0.006357947,
-0.007813617,
-0.0061653806,
-0.004282149,
0.026215108,
0.0047064475,
-0.014400031,
0.034727182,
-0.00013024734,
0.035092734,
-0.024256807,
-0.008081251,
0.022259342,
-0.028617289,
0.0007490497,
0.0075329267,
-0.018447185,
0.015509735,
-0.00951081,
0.013290328,
-0.0046052686,
-0.022846831,
-0.010398572,
0.022220176,
-0.021697963,
-0.001290846,
-0.035510503,
0.002403813,
0.0026877664,
-0.053996854,
-0.00520255,
-0.0028215838,
-0.020992974,
-0.011136198,
-0.019426335,
-0.0046836003,
0.020366319,
-0.020144377,
0.04091541,
-0.0051470646,
-0.001622941,
0.007846255,
-0.026162885,
-0.02989671,
-0.030105596,
-0.017350536
] |
Farnesoid X receptor (FXR), a bile-acid-activated member of the nuclear receptor superfamily, is essential in regulating bile-acid, cholesterol, and triglyceride homeostasis. Disruption of the FXR gene in mice results in a proatherosclerotic lipid profile with increased serum cholesterols and triglycerides. However, the role of FXR in foam-cell formation and atherosclerosis development remains unclear. The current study showed that the peritoneal macrophages isolated from FXR-null mice took up less oxidized LDL-cholesterol (oxLDL-C), which | [
-0.01752796,
-0.003514336,
-0.013418374,
-0.034006666,
-0.03336097,
0.004741831,
-0.028760385,
0.006756269,
-0.01483756,
-0.0048191804,
0.027442088,
-0.0028669583,
0.009355868,
0.008077928,
-0.017205114,
0.0021203721,
0.029083231,
0.002372597,
0.019680282,
0.010761603,
-0.015012437,
0.02570678,
-0.010795233,
-0.025720231,
-0.007210274,
0.006258545,
0.014864464,
-0.044553038,
-0.023056734,
-0.03901081,
0.015927173,
0.007741628,
-0.012456556,
0.003359638,
0.0015368914,
0.006493955,
0.009053199,
-0.01517386,
0.006762995,
-0.019989677,
0.034679268,
0.008340242,
0.003934711,
0.03435642,
0.006863885,
-0.0060937577,
0.0089993905,
-0.027347924,
-0.012638157,
0.008131736,
0.009665265,
0.007990491,
-0.0010585046,
-0.041647404,
-0.016371088,
0.012718869,
-0.00071379694,
0.0025457917,
-0.007714724,
-0.0164518,
-0.014070796,
0.003477343,
-0.01658632,
0.0008109036,
0.00019978327,
0.02940608,
-0.00560276,
0.028518248,
-0.01372777,
0.01912875,
0.031396978,
0.022491751,
-0.00725063,
0.020433594,
0.029486792,
0.012147159,
-0.027711129,
0.0028535062,
-0.01596753,
0.004714927,
0.036347315,
0.0028131504,
-0.0027559793,
0.018563766,
0.029594408,
0.001814339,
0.007425506,
0.027294116,
0.0013115704,
-0.00018675164,
0.015994433,
0.023245063,
0.030670568,
0.024079086,
-0.005868437,
0.0049301595,
0.01362688,
0.01234894,
-0.007331342,
-0.032580752,
-0.011629257,
0.0117234215,
-0.0138690155,
-0.0140977,
-0.023312323,
0.011588901,
-0.024361579,
0.0020043487,
0.01912875,
-0.003114139,
-0.009483662,
0.03578233,
0.010694343,
-0.016909169,
0.03952199,
-0.02067573,
0.030078681,
0.001696634,
0.0022599366,
-0.008138462,
0.012739047,
0.016613225,
-0.0046207635,
0.017258922,
0.0050915834,
-0.009564375,
-0.01537564,
-0.00084243173,
-0.014191864,
0.003363001,
0.018402342,
-0.011050821,
0.027576609,
-0.0037833762,
-0.027132692,
0.003655582,
-0.029567504,
-0.0003482808,
-0.0061139357,
-0.021872958,
0.0057204645,
0.027132692,
-0.023191255,
0.0018328355,
0.02001658,
0.02873348,
0.017339634,
0.0072371783,
-0.00026147332,
0.004439161,
0.0022616182,
-0.011649435,
0.02779184,
-0.004728379,
0.009053199,
0.0049267965,
0.003090598,
0.031773634,
0.0025726957,
-0.012584349,
0.00560276,
-0.0248324,
0.0046274895,
0.01571194,
0.028141592,
0.024859304,
0.010512741,
0.022599366,
0.007109384,
0.0059794155,
0.022384135,
0.016169308,
-0.011622531,
0.019586118,
0.00741878,
0.023836952,
-0.025478095,
0.007748354,
0.0020850606,
-0.0031494503,
-0.027899455,
0.004028875,
0.037557993,
-0.013048444,
-0.004358449,
0.011050821,
0.021173455,
-0.031181745,
0.0056733824,
-0.035836138,
-0.0016915895,
0.0117032435,
-0.007102658,
-0.018200561,
-0.63536507,
-0.011434203,
-0.008051025,
0.0015873364,
-0.0046409415,
0.03519044,
-0.0038943551,
-0.004368538,
-0.002190995,
0.009651813,
-0.011407299,
0.014891368,
0.030858897,
-0.030509144,
-0.020218361,
-0.023527555,
-0.0056397524,
-0.008468037,
0.024940016,
-0.012974458,
0.0021052386,
0.011023917,
-0.023191255,
0.02538393,
0.014743396,
0.022774242,
0.008346968,
-0.023393035,
0.011508189,
-0.0003379816,
-0.01665358,
0.026325572,
-0.001851332,
0.01396318,
0.054803465,
-0.01184449,
0.008871596,
0.023150899,
0.031666018,
0.043557588,
-0.012086625,
0.00701522,
0.020864058,
-0.008272982,
-0.012846664,
0.0028972253,
0.014016988,
0.029567504,
0.009228075,
0.008568927,
-0.025531903,
0.013552894,
-0.0030216563,
-0.003924622,
-0.0019034585,
0.0043147304,
0.021160003,
-0.015106601,
-0.003645493,
0.022814598,
-0.013922824,
0.022209259,
-0.014218768,
-0.0063022636,
-0.013068622,
0.0100486465,
-0.019115297,
0.0057002865,
0.015146956,
-0.000807961,
0.006554489,
0.029944161,
-0.0045299623,
0.021644274,
0.0033747714,
0.030831993,
0.011440929,
0.023594815,
-0.0066217487,
0.030912705,
0.0051117614,
0.0048965295,
-0.00033693065,
0.0033848605,
0.018092945,
-0.0010475748,
0.01571194,
0.014729944,
0.011615805,
-0.01711095,
0.01298791,
-0.0022195806,
-0.026823295,
-0.036831588,
-0.01618276,
0.018671382,
-0.010600179,
0.020904414,
0.010189893,
-0.02524941,
-0.016492156,
-0.0009988113,
0.0058314437,
0.0037699242,
0.021778794,
0.0051622065,
-0.025410835,
-0.015294928,
0.024953468,
-0.04584443,
-0.0054581505,
-0.0066654678,
-0.0042777373,
-0.01704369,
-0.012557446,
-0.017124401,
0.014931724,
0.0024449017,
-0.0048528104,
-0.04519873,
0.037262052,
-0.015806105,
0.021065839,
-0.012584349,
0.02424051,
0.017568316,
0.0048090913,
-0.007324616,
-0.012839938,
-0.018200561,
0.018335082,
0.012207693,
0.014514712,
-0.02403873,
0.017285826,
0.0057809986,
0.029029423,
0.011366943,
0.0049267965,
-0.03747728,
-0.032661464,
-0.0022986112,
0.007069028,
-0.018133301,
-0.009598005,
-0.0028686398,
0.02659461,
0.017649028,
0.011467833,
0.012631431,
-0.0023322413,
0.0017176528,
-0.027226856,
0.022532107,
0.017904617,
-0.004207114,
-0.006927782,
-0.0030990054,
-0.0015057836,
-0.00029026903,
-0.008313338,
0.001683182,
-0.007882874,
0.018227465,
-0.006147566,
-0.0023641896,
0.020137649,
0.00782234,
0.0009954483,
-0.022128547,
0.011494737,
-0.014218768,
-0.020433594,
0.0020346155,
-0.003383179,
0.017487604,
0.0031881249,
-0.009201171,
0.0029897077,
-0.019787898,
0.0026466819,
-0.0023339228,
-0.018846257,
-0.0024264052,
0.016841909,
0.0016789782,
0.010936479,
0.023984922,
-0.0038943551,
0.012005913,
-0.03395286,
0.010909575,
-0.014353288,
0.011635983,
0.01704369,
-0.041593596,
0.026554255,
0.009349142,
0.020729538,
0.01980135,
0.0133174835,
-0.029944161,
0.034060474,
-0.034517843,
0.012429652,
-0.02323161,
0.01184449,
-0.00054606725,
-0.004442524,
-0.006742817,
-0.0057339165,
-0.009907401,
0.0057944506,
-0.02577404,
-0.0012451512,
-0.011561997,
0.022868406,
-0.004133128,
0.01187812,
-0.041243844,
-0.00832679,
-0.0100553725,
0.026863651,
0.013546168,
0.0018849621,
0.0045568664,
0.010781781,
-0.001800887,
0.0028400542,
-0.016048241,
-0.006675557,
-0.014555068,
-0.013108978,
0.013371292,
0.0020850606,
0.0058549847,
-0.003450439,
-0.0077618062,
0.003369727,
-0.0082259,
0.020218361,
-0.008380598,
0.028868001,
0.01372777,
-0.0016596409,
-0.02101203,
0.012691965,
0.003504247,
-0.0030636939,
-0.0014856057,
-0.003393268,
0.007055576,
-0.015025889,
0.0055657667,
0.01251709,
0.006490592,
0.01966683,
-0.011952105,
0.040302202,
0.008804336,
0.028087784,
0.00691433,
-0.013687414,
-0.015779201,
0.008010669,
0.03435642,
-0.01832163,
-0.0049604266,
-0.009127185,
-0.0024146347,
-0.024953468,
0.0013460411,
-0.0011299683,
-0.031961963,
0.022195807,
0.01986861,
0.0308858,
0.0072371783,
0.03180054,
-0.006598208,
-0.008622735,
-0.03839202,
0.028437536,
0.012611253,
-0.007869422,
-0.021846054,
-0.027468992,
-0.008017395,
0.026016176,
0.020729538,
0.021913314,
-0.012947554,
0.02168463,
-0.004166758,
-0.019908966,
-0.006810077,
0.033925954,
-0.029459888,
0.011077725,
-0.0022532106,
-0.0001437683,
-0.0053101787,
-0.014218768,
-0.005007508,
0.031531498,
0.006534311,
-0.0055859447,
0.0075263963,
0.0058247177,
-0.024025278,
0.02323161,
-0.010896123,
-0.0023221523,
-0.028007071,
-0.0024095902,
-0.0037598351,
-0.019061489,
-0.0008125851,
0.025720231,
-0.0027509348,
-0.011266054,
-0.04350378,
-0.0032032584,
0.0060197716,
0.008165366,
0.0084344065,
-0.011750326,
0.011817586,
0.009994838,
0.006789899,
0.0011257646,
-0.019693734,
0.0052193776,
0.000104305574,
0.020097293,
0.013162786,
-0.001780709,
0.0025760587,
-0.0088985,
0.009261705,
-0.0025693327,
-0.03987174,
-0.00017456077,
-0.025814395,
-0.008945582,
-0.015415996,
0.02081025,
0.02792636,
0.017326182,
-0.0057978136,
-0.0054211575,
0.033253353,
0.0037631982,
-0.021577014,
-0.009376046,
-0.001622648,
-0.008030847,
0.00614084,
0.009423128,
-0.006261908,
-0.0053808014,
-0.02403873,
-0.016599772,
-0.007196822,
0.0053337193,
0.0040187864,
0.007358246,
-0.0044996953,
0.0058718,
-0.009490388,
-0.013539442,
-0.009389498,
0.014528164,
-0.017474152,
0.00014481923,
0.0046712086,
-0.006530948,
0.009429854,
-0.00024444814,
-0.008925404,
0.018765545,
0.003114139,
-0.0095172925,
-0.0046174005,
-0.0047720983,
-0.008306612,
0.013680688,
0.000186016,
0.026258312,
-0.011521641,
0.003235207,
-0.037692513,
-0.02067573,
0.016330732,
0.022330327,
-0.024294319,
-0.017353086,
0.009618183,
0.003453802,
0.007997217,
-0.0002822819,
-0.021119647,
0.03545948,
0.022074739,
-0.019680282,
-0.004388716,
-0.0055523147,
-0.016989881,
0.0039750673,
0.011669613,
0.021980574,
-0.025464643,
-0.0019858521,
0.009725799,
0.012288406,
-0.013754674,
0.0261776,
-0.024200154,
-0.014043892,
-0.011837764,
0.004358449,
0.013061896,
0.009806511,
-0.004479517,
-0.020299073,
-0.00768782,
-0.009180993,
-0.014218768,
-0.006900878,
-0.01786426,
0.023177803,
-0.0033041483,
-0.026971268,
-0.011124807,
-0.0053774384,
0.0122682275,
-0.027711129,
-0.020258717,
0.003534514,
0.021361781,
-0.013223319,
0.039952453,
-0.0048931665,
-0.011044095,
0.01318969,
-0.014622328,
0.02302983,
0.01766248,
-0.01759522,
0.020325977,
0.004166758,
-0.006161018,
-0.018214013,
0.015469804,
0.0063258046,
0.01403044,
-0.015052793,
-0.027347924,
-0.03572852,
0.0043483605,
-0.017716289,
-0.009207897,
-0.013014814,
-0.006157655,
-0.015362188,
0.0111853415,
0.006877337,
-0.02403873,
0.03591685,
-0.03215029,
0.0008588264,
0.007640738,
-0.0127861295,
0.009631635,
-0.003601774,
-0.011077725,
-0.036266603,
-0.02444229,
-0.018335082,
-0.028437536,
0.010990287,
-0.018967325,
0.015335284,
0.02255901,
0.02563952,
-0.004442524,
0.00333946,
0.0054077054,
-0.006433421,
0.0052126516,
-0.0018866436,
0.015146956,
-0.02659461,
0.019142201,
0.010425303,
0.0019757631,
0.02417325,
-0.027401732,
0.017258922,
0.01382866,
-0.0078963265,
-0.0053034527,
0.0040154234,
-0.011757052,
-0.01818711,
-0.0030519234,
-0.0040053343,
-0.013936276,
-0.03449094,
-0.01416496,
0.028894905,
0.010277331,
0.021455945,
-0.011279505,
0.031719826,
-0.022774242,
0.012860116,
-0.00364213,
0.002069927,
0.00772145,
-0.024213606,
0.0164518,
0.0019774446,
-0.0027088972,
-0.007627286,
0.015469804,
0.004116313,
0.00013462514,
0.010358043,
-0.006995042,
-0.00711611,
0.0005006668,
-0.00013283854,
-0.010727973,
-0.012846664,
-0.015563969,
0.007694546,
-0.043261643,
-0.011037369,
0.029513696,
-0.02255901,
0.02241104,
0.008885048,
-0.027132692,
0.010815411,
-0.009180993,
0.032419328,
-0.03524425,
0.0329036,
0.0053068157,
0.0053774384,
-0.024469195,
-0.020379785,
0.017353086,
-0.021509754,
0.040920995,
0.0133376615,
-0.0053337193,
-0.010021742,
-0.02417325,
0.007580204,
-0.021442493,
-0.02980964,
-0.001743716,
-0.0079232305,
-0.006177833,
-0.0014570202,
-0.007001768,
-0.02551845,
0.0051588435,
-0.026769487,
-0.012510364,
-0.0054615135,
-0.0053135417,
-0.019774446,
0.03519044,
-0.009934305,
-0.003864088,
-0.014958628,
0.003544603,
0.00745241,
-0.036966108,
-0.013499086,
-0.006699098,
0.005935697,
0.033253353,
-0.004476154,
0.012893746,
0.0061038467,
0.024428839,
-0.0030788274,
-0.031020321,
-0.025370479,
0.04215858,
-0.014514712,
0.011144985,
0.02518215,
0.0017075638,
0.0029678484,
-0.022881858,
-0.012207693,
-0.030186297,
-0.03034772,
0.007580204,
0.02698472,
-0.014474357,
-0.034194995,
0.01731273,
-0.01838889,
-0.010532919,
-0.036401123,
-0.010553097,
0.034679268,
-0.046624646,
0.0053438083,
-0.0031561763,
0.011434203,
0.004708201,
0.00893213,
-0.003487432,
-0.007405328,
0.017675932,
-0.037988458,
0.02195367,
-0.002214536,
0.017057141,
-0.029971065,
0.009254979,
-0.011931927,
-0.031047225,
0.011905024,
-0.03013249,
-0.039118428,
-0.043584492,
-0.023325775,
0.0049167075,
0.026796391,
0.0031898064,
0.009719073,
-0.009423128,
0.010727973,
0.004701475,
0.0044896062,
0.0063459827,
-0.012389296,
0.010458933,
0.0017487605,
-0.003635404,
-0.0034386686,
-0.0014149826,
0.0057540946,
0.020245265,
0.031639114,
0.017891165,
-0.011595627,
0.014783752,
-0.02437503,
-0.0007352361,
-0.02637938,
-0.014124604,
-0.02316435,
0.016492156,
0.0069345077,
-0.031450786,
-0.013667236,
-0.0053202673,
-0.011864668,
0.0025188876,
-0.010875945,
-0.014057344,
0.0003463891,
0.0005662453,
-0.029513696,
-0.00017886961,
-0.022491751,
0.034733076,
0.007479314,
-0.022935666,
-0.0021153276,
0.0059962305,
-0.0100688245,
-0.015631229,
-0.016841909,
0.012913924,
-0.01238257,
-0.0056532044,
0.0054177945,
0.010559823,
-0.0025138431,
0.013936276,
-0.0074927662,
-0.026056532,
0.015066245,
-0.014407096,
0.03026701,
0.0030014783,
-0.02121381,
-0.015833009,
0.03075128,
-0.012833212,
-0.0049839676,
0.018926969,
-0.021872958,
0.022343779,
-0.017918069,
0.0050714053,
0.02510144,
0.016397992,
0.032795984,
-0.028222304,
0.01530838,
-0.0014343199,
-0.004472791,
-0.010647261,
0.0032738815,
-0.003924622,
0.008239352,
-0.001184617,
-0.0060937577,
-0.0023709156,
0.019155653,
-0.012026091,
0.004186936,
-0.005629664,
-0.006968138,
-0.004459339,
0.0061307508,
-0.02510144,
-0.009476936,
-0.012476734,
-0.015254572,
0.01315606,
-0.006995042,
0.011131533,
-0.0008642913,
0.00026063257,
-0.0026197778,
-0.024509551,
0.020783346,
-0.024415387,
0.0043147304,
-0.03395286,
0.03075128,
-0.018133301,
-0.0052059256,
-0.015146956,
-0.002966167,
-0.015658133,
-0.006900878,
-0.00704885,
-0.0023793231,
-0.023043282,
0.0033377784,
0.009826689,
-0.010660713,
-0.026675323,
0.013990084,
-0.03938747,
0.0053740754,
0.025787491,
0.1986592,
-0.024321223,
-0.001763894,
0.012153885,
0.011461107,
-0.00698159,
-0.0043080044,
0.004351723,
-0.023998374,
0.02577404,
0.03263456,
0.026406284,
-0.024186702,
0.00076802535,
-0.00017834414,
-0.0122480495,
-0.029863449,
0.0038943551,
0.0055186846,
-0.026513899,
0.02081025,
-0.009207897,
0.003685849,
-0.026756035,
0.05633699,
0.0028299652,
-0.027872551,
-0.011447655,
0.013068622,
0.006762995,
-0.011306409,
-0.0016630039,
0.0053572604,
0.01234894,
-0.0023019742,
0.008252804,
-0.02020491,
0.009618183,
0.0056632934,
-0.003363001,
0.0004514829,
0.0078896005,
-0.014729944,
-0.011440929,
0.003941437,
-0.00034617892,
0.016021337,
-0.009846867,
-0.020917866,
0.007607108,
-0.049772415,
0.014084248,
0.004200388,
0.01711095,
-0.022061286,
-0.021671178,
0.022330327,
0.021698082,
0.020850606,
0.028868001,
-0.00183788,
0.020083841,
-0.031719826,
0.0396027,
-0.026742583,
0.037504185,
-0.018725188,
-0.014958628,
0.019169105,
-0.015685037,
-0.0013300668,
0.011131533,
-0.012059721,
-0.016559416,
0.0048696254,
-0.0008024961,
-0.010512741,
0.022128547,
0.014743396,
0.016397992,
0.0043349084,
-0.013936276,
-0.03866106,
0.010674165,
-0.02001658,
-0.035836138,
0.012631431,
0.013310757,
-0.022437943,
-0.0054514245,
0.0056901975,
-0.00063224416,
-0.011898298,
-0.015725393,
0.0006372887,
-0.017743193,
0.0027105787,
0.0015764066,
-0.019882062,
0.0051891105,
-0.038284402,
0.060587823,
-0.027334472,
0.027025076,
-0.016478704,
0.004385353,
-0.017608672,
0.025464643,
-0.0052563706,
0.0053505343,
0.0127928555,
-0.017608672,
-0.00036593655,
-0.0061240247,
0.0011947061,
0.010189893,
0.027845647,
-0.0056733824,
0.007438958,
-0.00333946,
-0.01181086,
-0.0033041483,
0.010398399,
0.017393442,
-0.0018361985,
-0.017635576,
-0.020958222,
-0.03336097,
-0.017353086,
-0.032742176,
-0.016223116,
-0.019007681,
0.0039010812,
0.006715913,
-0.006248456,
-0.007190096,
0.013768126,
-0.00357487,
-0.0059794155,
0.03317264,
-0.015389092,
0.016909169,
0.021025483,
0.007674368,
0.024603715,
-0.023016378,
0.016276924,
0.0066116597,
-0.01737999,
0.026648419,
-0.019572666,
-0.006238367,
-0.014339836,
-0.0028989068,
0.03128936,
-0.034410227,
-0.007849244,
-0.049234334,
0.025787491,
0.010761603,
-0.027764935,
0.0054110684,
0.027213404,
-0.017998781,
0.0026029628,
0.0026382743,
-0.17035617,
0.0015293247,
0.013115704,
-0.019545762,
0.019639926,
0.0100553725,
0.017608672,
0.015577421,
-0.011763778,
-0.0012064766,
0.024711331,
0.0060836687,
-0.017218566,
-0.02033943,
0.014918272,
0.0048797145,
-0.018698284,
0.022706982,
-0.0051521175,
0.026904007,
0.038311306,
-0.008790884,
0.018617574,
-0.024227059,
0.02624486,
0.015563969,
0.006776447,
0.0019303625,
-0.0018563765,
0.0015696808,
-0.009799785,
-0.0051655695,
0.038983908,
0.0042138402,
0.017675932,
-0.0013216594,
-0.00095845526,
-0.010203345,
0.0026180963,
0.023836952,
0.012611253,
0.032715272,
-0.0009609775,
-0.000019455487,
-0.024253963,
0.0030115673,
-0.011884846,
-0.0026887192,
0.027630417,
0.0027812019,
0.0072237263,
-0.006769721,
-0.0010122632,
0.020621922,
0.033145737,
0.029459888,
0.003601774,
0.031020321,
-0.0026836747,
-0.0063728867,
-0.0054917806,
-0.0063560717,
0.03330716,
-0.018415794,
0.0063930647,
-0.009880497,
-0.020662278,
-0.011595627,
-0.012759225,
-0.011353491,
-0.027442088,
-0.0017958425,
0.0116965175,
0.0052866377,
0.028706577,
0.007432232,
-0.021590466,
0.01382866,
0.022424491,
0.006927782,
0.011898298,
-0.0066621047,
-0.029513696,
-0.0144340005,
0.0023019742,
0.018926969,
0.00725063,
0.012288406,
-0.0028484617,
0.0014931724,
0.028410632,
-0.021603918,
-0.00077138835,
-0.0016436668,
0.012342214,
0.021388685,
-0.0048864405,
-0.01919601,
-0.00018874842,
0.015833009,
0.02215545,
-0.018711736,
-0.014891368,
-0.006598208,
0.021200359,
-0.0077752583,
-0.02510144,
0.00768782,
0.045898236,
-0.032580752,
0.0051016724,
0.0006978227,
-0.005928971,
0.028141592,
-0.0058112657,
-0.0089926645,
0.009113733,
-0.011232424,
0.0002433972,
-0.039629605,
0.06951996,
0.020648826,
0.014003536,
0.029379176,
-0.00370939,
-0.016411444,
-0.124296516,
-0.027307568,
-0.011817586,
0.023177803,
-0.022639722,
0.030374624,
-0.0043315454,
0.016075145,
-0.012389296,
0.025087988,
-0.004200388,
-0.010842315,
-0.0047889133,
-0.019061489,
0.020998579,
0.0005414432,
0.023608267,
-0.005633027,
-0.011131533,
0.03887629,
-0.0006200533,
-0.033387873,
-0.003423535,
0.001797524,
0.00313768,
0.0063123526,
-0.020137649,
0.00014166642,
-0.008003943,
0.007950135,
0.02027217,
0.00046241263,
0.014729944,
-0.034410227,
-0.017783549,
-0.03475998,
0.022518655,
-0.019007681,
0.032742176,
-0.0048528104,
0.008871596,
0.0013603339,
0.0042138402,
-0.0050579533,
-0.0100755505,
-0.004422346,
-0.029056327,
0.0050512273,
0.0048595364,
0.006214826,
-0.03591685,
-0.029486792,
-0.027146144,
-0.015846461,
0.03637422,
0.0072371783,
0.0021371872,
0.02094477,
-0.026863651,
-0.010822137,
0.023419939,
0.018160205,
-0.007358246,
0.011494737,
0.009349142,
-0.028948713,
0.018496506,
-0.032742176,
0.0048561734,
-0.015025889,
-0.007143014,
0.022007478,
-0.0043248194,
0.007640738,
-0.028491344,
0.021052387,
-0.023500651,
0.0018092946,
0.018832805,
-0.046866782,
0.0021994025,
-0.019290173,
0.012718869,
-0.014622328,
0.011757052,
0.025410835,
0.02081025,
0.003729568,
-0.0043248194,
-0.02637938,
-0.022814598,
0.030831993,
0.0007667642,
-0.013586524,
-0.022733886,
-0.0012300176,
0.02047395,
0.012046269,
0.016882265,
-0.003457165,
-0.01339147,
-0.01724547,
-0.061179712,
0.020514306,
0.0051487545,
-0.0016562779,
0.0023255153,
-0.016290376,
0.019370886,
-0.019451598,
-0.008084654,
-0.009376046,
-0.020124197,
0.008844692,
0.0027425273,
0.0022431216,
-0.009066651,
-0.023810048,
0.041781925,
-0.0024987096,
0.024913112,
0.0322041,
0.018066041,
0.020366333,
0.014581972,
-0.0034420316,
-0.026998172,
0.0033142373,
-0.009416402,
0.027576609,
-0.00839405,
-0.001626011,
-0.016828457,
-0.03282289,
-0.015886817,
0.017097497,
-0.017487604,
-0.009786333,
-0.01470304,
0.00768782,
0.019720638,
0.017608672,
-0.0059895045,
-0.024213606,
0.006907604,
-0.0066217487,
0.007102658,
-0.00805775,
-0.0295406,
0.0033882235,
0.0006608297,
-0.0012098396,
0.013310757,
0.0042138402,
0.003117502,
-0.020083841,
-0.02067573,
-0.000038149043,
0.0029930708,
-0.029352272,
-0.031773634,
-0.038176786,
0.01517386,
0.031639114,
0.007338068,
-0.012429652,
0.009450032,
-0.024926564,
-0.015631229,
-0.0046241265,
0.043154027,
-0.048776966,
-0.046839878,
0.019882062,
0.004725016,
0.0057103755,
0.011662887,
-0.006995042,
-0.021738438,
-0.0026063258,
-0.015362188,
0.006884063,
0.0036219521,
-0.018348534,
-0.02195367,
0.017205114,
0.0072237263,
0.000012263131,
-0.02020491,
-0.0261776,
0.009288609,
0.03416809,
-0.007438958,
0.031719826,
0.014743396,
0.01456852,
0.0018462875,
0.013384744,
0.0015831327,
-0.00007540479,
0.0015158727,
0.022168903,
-0.010949931,
-0.00014250717,
-0.006211463,
-0.0161155,
0.00381028,
0.007075754,
-0.02469788,
-0.04705511,
-0.026661871,
-0.014003536,
-0.006900878,
0.010600179,
0.008118284,
0.0042609223,
-0.009967935,
0.02302983,
-0.0005452265,
0.0025087986,
0.0046611195,
-0.0016562779,
0.02637938,
0.020003129,
-0.014043892,
0.006752906,
0.009745977,
0.003564781,
0.056283183,
-0.023890758,
0.018348534,
-0.017258922,
0.02141559,
0.003706027,
-0.028276112,
-0.014877916,
0.016693937,
0.000073880925,
-0.0011366943,
0.021254167,
-0.03330716,
0.0845862,
0.014191864,
-0.012718869,
-0.016223116,
0.0039885193,
0.044606846,
-0.010284057,
0.011319861,
-0.019182557,
-0.0063459827,
0.035567097,
-0.03408738,
0.018173657,
-0.015913721,
-0.032876696,
0.014420548,
-0.0033579564,
-0.0017655755,
0.0058112657,
-0.021980574,
-0.0026920822,
-0.02792636,
0.01845615,
-0.0074994923,
-0.04718963,
-0.010741425,
0.05181712,
0.009914127,
0.0042340183,
-0.0161155,
-0.017931521,
0.004741831,
-0.021994026,
0.0029644854,
0.02355446,
-0.019962775,
-0.0038876291,
-0.007264082,
0.012194241,
0.02631212,
0.0011585539,
0.028572056,
-0.014057344,
-0.037342764,
0.0050814943,
0.0004107065,
-0.008340242,
0.010479111,
-0.04624799
] |
The cerebellum is organized into a series of parasagittally aligned bands that may be revealed histologically in the adult mouse by largely complementary immunostaining of Purkinje cell sets with the monoclonal antibodies Zebrin II (ZII; antigen:aldolase C) and P-path (PP; antigen:90-acetyl glycolipids). We compared the normal staining pattern using these markers and an antibody to calbindin with that found in the reeler mutants (rl/rl), in which most Purkinje cell migration is halted beneath the cerebellar white matter. The results revealed that Purkin | [
-0.019859277,
-0.005851634,
0.007773066,
-0.010675369,
-0.025757939,
0.029345509,
-0.009284683,
-0.00059666845,
-0.0036077239,
0.018287197,
0.0010833249,
0.0049446644,
0.016446384,
0.008673318,
-0.011783888,
0.0077394745,
0.027222527,
0.01275804,
-0.010970974,
0.010957537,
-0.014014361,
0.010252116,
0.003523745,
-0.02767937,
0.017695986,
0.013906868,
-0.0015401689,
-0.012448999,
0.0016762144,
0.0036379562,
0.009761681,
0.011958564,
0.015452076,
-0.013839685,
0.0048506083,
-0.034962002,
0.0031492002,
-0.009204063,
0.0033440308,
0.012663984,
0.0046121087,
0.0027225886,
-0.026550697,
-0.010507411,
0.003611083,
0.01670168,
-0.019993642,
-0.016621059,
-0.0072154477,
0.01429653,
-0.0020272452,
-0.0014519913,
-0.008572543,
0.018206576,
-0.015935794,
-0.037729938,
0.013879995,
0.021606034,
-0.009788554,
-0.024535209,
-0.01602985,
-0.009284683,
-0.0048371716,
0.0025999798,
0.01283866,
0.0013629739,
0.006745167,
-0.004937946,
0.0026554058,
-0.021968821,
0.03265091,
-0.0021330584,
-0.0050756712,
-0.0027461026,
0.036601264,
-0.017413817,
-0.02961424,
-0.0040074624,
-0.0033910589,
0.01870373,
0.017400382,
-0.025690757,
-0.005596339,
0.018757477,
0.020934204,
-0.0053847125,
0.0065872874,
0.01945618,
-0.004081364,
0.0069803074,
0.011387508,
0.034558903,
0.021941949,
0.010245399,
-0.025368279,
0.012119803,
0.002299336,
0.0261476,
0.0055728247,
-0.011589057,
0.0138531225,
0.020060826,
-0.013134264,
-0.0132283205,
-0.018959025,
-0.022304736,
-0.0046591368,
-0.007941023,
0.021377612,
0.0019986925,
-0.004366891,
0.018730603,
-0.009244372,
-0.045281302,
0.0148474295,
-0.00045306495,
0.022936255,
0.02251972,
0.00029203584,
-0.019993642,
0.014914612,
0.024212731,
0.022452539,
-0.040094778,
0.031495363,
0.024629265,
-0.007833531,
-0.008444896,
-0.005210037,
-0.00008975221,
-0.0073766867,
0.012012309,
0.014377149,
-0.004864045,
0.011864508,
-0.013416433,
0.0022909383,
0.013140983,
-0.00017698505,
-0.03171035,
0.0077126017,
0.00949295,
-0.020074263,
-0.011421099,
-0.0020104495,
0.019348687,
0.025193602,
0.025663882,
0.01701072,
0.0065940055,
-0.0057945284,
-0.0066645476,
0.009553414,
-0.0051697274,
0.010030413,
0.025327967,
-0.0023480437,
0.044394486,
-0.011555466,
-0.028781172,
-0.02886179,
0.005599698,
0.0050353613,
-0.0075782356,
-0.0015687216,
0.025287658,
-0.004222448,
-0.011844352,
0.011407663,
-0.020356432,
-0.009365302,
0.021108879,
-0.02272127,
0.01654044,
-0.007887277,
0.0006243815,
0.017400382,
0.01543864,
-0.03469327,
-0.01629858,
-0.011004565,
0.00070164184,
0.00016743249,
0.0050756712,
0.00496146,
0.005932254,
0.033537723,
-0.01275804,
-0.0028334404,
-0.025018927,
0.015747681,
-0.015290837,
-0.01578799,
-0.02251972,
-0.63807666,
-0.030151702,
0.0060498235,
-0.008673318,
0.015761118,
0.034290172,
0.00031806924,
-0.012173548,
-0.014981795,
0.009338428,
0.0015997938,
0.014229347,
0.0037219347,
-0.0061606755,
-0.029211143,
-0.027383767,
0.0075916722,
-0.017937845,
0.022345046,
0.006402534,
-0.03197908,
-0.0031525595,
-0.0011454691,
0.017319761,
0.013906868,
0.032785274,
0.024723321,
-0.03783743,
-0.0027864124,
0.036950618,
-0.026940359,
0.036036927,
-0.02618791,
0.0075379256,
0.03934233,
0.009506386,
-0.04033664,
0.017655676,
0.021606034,
0.047001183,
0.00029602484,
-0.0014225987,
0.017991591,
-0.02673881,
-0.042271506,
-0.0013235039,
-0.0010329377,
0.0014486321,
0.017292889,
-0.024871124,
-0.0096877795,
-0.02165978,
-0.019026209,
0.012596801,
0.0072826305,
-0.0048203757,
0.01894559,
-0.003752167,
0.017118214,
-0.0031324045,
0.0012302876,
0.0044676657,
-0.0011757014,
-0.005344403,
-0.026483515,
-0.00013321117,
-0.011333762,
-0.0074371514,
0.022116624,
-0.005660163,
0.008935331,
0.008794247,
-0.010675369,
0.009640751,
0.012704294,
0.02414555,
0.016164215,
0.009849019,
-0.013302222,
-0.003291964,
-0.02157916,
0.00909657,
-0.0130738,
-0.0010698884,
0.029238015,
-0.0052234735,
-0.016083596,
0.013181292,
0.015667062,
0.01212652,
-0.006187549,
-0.0023295684,
0.017292889,
-0.032032825,
-0.012919279,
0.025583263,
-0.010285708,
0.014833993,
0.0045785173,
-0.034988876,
-0.020235501,
0.0109373825,
0.004524771,
0.005582902,
0.009204063,
0.021753836,
-0.03157598,
-0.0061304434,
0.039369203,
-0.027652498,
-0.0030937744,
-0.008633007,
-0.023460282,
0.010043849,
0.01811252,
-0.01949649,
0.017790042,
0.029291762,
-0.013154419,
-0.022304736,
0.01870373,
-0.0064327666,
0.013718756,
0.0018878406,
0.018246887,
-0.014121854,
0.005969204,
-0.004390405,
-0.005414945,
0.0043097856,
-0.006533541,
0.0038462232,
0.015720807,
0.0017937844,
0.01831407,
0.013651573,
0.011253143,
-0.0095265405,
0.0009103288,
-0.035902563,
-0.044260122,
-0.014068107,
-0.0029879613,
-0.01476681,
0.012979744,
-0.016002975,
-0.027182218,
0.008061953,
-0.007752911,
0.026120726,
0.0089017395,
-0.0051059034,
-0.040578496,
0.0038327868,
0.018085647,
-0.0073968414,
-0.011226269,
-0.0071281097,
0.018730603,
-0.016782299,
0.009855737,
0.013396278,
-0.0027024338,
0.010520848,
-0.008438177,
-0.0185828,
0.012616956,
0.0101513425,
-0.010742552,
-0.026926922,
-0.00996323,
0.010292427,
-0.018636547,
0.022291299,
0.034209553,
0.01271773,
0.0059994366,
-0.009969948,
-0.02161947,
-0.0057710144,
0.0038428642,
0.008915176,
-0.014417459,
0.00080871466,
0.020154882,
0.0024992053,
0.035660703,
0.0037219347,
-0.0019516643,
0.0250458,
0.022237552,
0.030501055,
-0.01189138,
-0.011750296,
-0.008532234,
-0.028619932,
0.0029392536,
-0.018220013,
0.008706909,
0.027316583,
0.0070071807,
0.004091441,
0.019079955,
-0.0151833445,
0.009324992,
-0.03705811,
0.0021599315,
-0.03689687,
0.02343341,
0.002287579,
0.006039746,
-0.0037857587,
-0.0017568339,
-0.016285144,
-0.03197908,
0.0075312075,
0.01023868,
-0.002264065,
-0.0029510106,
0.0012202101,
-0.007504334,
0.007242321,
0.019590545,
0.0016157497,
-0.0006982827,
0.011622649,
-0.0018408125,
0.02161947,
0.004864045,
0.006033028,
-0.004407201,
0.028297454,
-0.0057004723,
0.012307915,
-0.0015771195,
0.012287759,
0.002729307,
0.0060431054,
0.030393561,
0.012973025,
0.0026940359,
0.039073598,
-0.014336839,
0.0081896,
0.0011723423,
-0.018139394,
0.026402894,
0.016312018,
-0.010178216,
0.023970872,
0.010097596,
-0.00421237,
-0.037434332,
0.0045785173,
-0.009640751,
-0.0066242376,
0.036090676,
-0.011629367,
0.03273153,
0.025327967,
0.019711474,
-0.019536799,
-0.008572543,
-0.023796197,
-0.00023723976,
0.0146055715,
0.010668651,
-0.0163792,
-0.007148265,
-0.005297375,
-0.019509926,
0.006305119,
0.003040028,
-0.019751783,
0.0023984308,
0.008619571,
0.0046994467,
0.0028300814,
0.03899298,
0.012952871,
-0.022828763,
-0.04619499,
0.014202474,
0.010547722,
-0.028512439,
-0.010332736,
-0.011568902,
-0.02106857,
-0.014068107,
0.002697395,
-0.0076319817,
0.022869073,
-0.0086934725,
-0.005297375,
-0.013947179,
-0.007154983,
0.016244834,
0.010742552,
0.02335279,
-0.02327217,
-0.024790505,
0.010010258,
-0.002972845,
-0.021364175,
0.03273153,
0.017104777,
-0.0069668707,
0.0020054108,
-0.011185959,
0.0072154477,
-0.001394046,
-0.011783888,
0.01870373,
-0.0055627474,
-0.019899586,
0.0032986824,
-0.00803508,
0.015371457,
0.046221863,
0.0060968515,
-0.028378073,
-0.024185859,
-0.001701408,
-0.022143496,
0.007826813,
0.032274686,
-0.012583365,
0.009277964,
0.007846967,
-0.013497053,
-0.0044273557,
-0.016795736,
0.019536799,
-0.0011320325,
-0.014659317,
-0.00058533135,
0.0055560293,
0.011904817,
0.016567312,
-0.0023564417,
-0.01330894,
-0.017695986,
0.010292427,
0.013772503,
0.02347372,
-0.007813375,
0.0137254745,
0.04681307,
0.00854567,
-0.0036950617,
-0.0053645577,
0.016217962,
0.021055134,
-0.03614442,
-0.012852096,
0.019429306,
-0.0031240068,
-0.0040343357,
-0.01590892,
-0.030501055,
0.012287759,
0.022345046,
-0.0037857587,
0.005498924,
0.018811222,
0.021955384,
0.006382379,
-0.016903227,
0.015653625,
-0.004561722,
0.0037958361,
-0.0068660965,
-0.0069131246,
-0.033215247,
0.037729938,
-0.010695524,
0.025112983,
-0.020638598,
0.030689167,
0.0008036759,
-0.009351865,
0.0038966106,
0.008075389,
-0.013510489,
0.011555466,
-0.030097958,
0.0042325254,
-0.0083239665,
-0.0066880616,
-0.010312581,
-0.01705103,
-0.014390586,
-0.01882466,
-0.009775118,
0.007054209,
-0.023151241,
-0.034155805,
-0.011239706,
0.017910972,
0.035848815,
0.01854249,
-0.014672754,
0.010352891,
0.03721935,
-0.0075513623,
-0.0084852055,
-0.016728552,
-0.017695986,
-0.012113084,
-0.00056685606,
0.028539313,
-0.020531107,
0.010211807,
-0.009170472,
0.02276158,
-0.0012815145,
0.018461872,
0.0122340135,
-0.012287759,
0.007309504,
0.02067891,
0.034639522,
-0.009002514,
-0.02661788,
0.005807965,
-0.0096877795,
0.015814863,
-0.0030467464,
-0.0055425926,
-0.014430895,
-0.02200913,
0.006389098,
-0.010433511,
-0.0004186337,
-0.008317248,
-0.0012966307,
0.033645216,
0.039234836,
0.015680498,
0.016809171,
0.009519823,
0.03192533,
0.00626145,
-0.020450488,
0.028109342,
0.0026638035,
0.017400382,
-0.011118776,
-0.02157916,
0.012677421,
-0.0032936437,
-0.007947742,
-0.013483616,
0.012509463,
-0.009580287,
0.030689167,
-0.005414945,
-0.03192533,
-0.035929438,
0.006234577,
0.0076387003,
0.022291299,
0.010373046,
0.014336839,
-0.011367354,
0.019066518,
0.0054485365,
-0.00370178,
0.0077999393,
-0.042432744,
-0.008868148,
0.03824053,
-0.013671728,
0.017171958,
0.0021129034,
0.0068862513,
0.010897073,
0.0065940055,
-0.020208629,
-0.029049903,
-0.003213024,
-0.008041798,
0.031334125,
0.025341405,
0.02618791,
0.018166266,
0.0017988232,
0.0122340135,
-0.013866559,
-0.0027309866,
-0.011622649,
0.010332736,
-0.018838096,
0.03197908,
0.0019247913,
-0.0059356126,
-0.004823735,
-0.011609212,
0.03729997,
0.019429306,
-0.0046658553,
-0.025018927,
0.0010841647,
-0.03383333,
-0.023218423,
0.028512439,
-0.017534748,
-0.010070723,
-0.01095082,
-0.013799376,
0.030393561,
0.008256784,
0.00039868875,
-0.015505822,
0.021753836,
-0.039503567,
0.030904151,
-0.003973871,
0.014833993,
-0.0113539165,
-0.018529056,
-0.0017383585,
0.0046356227,
0.0030333097,
0.0141756,
-0.0027041133,
-0.0013512169,
-0.02390369,
0.0027276273,
0.0008910137,
-0.01756162,
0.0067552445,
-0.032785274,
-0.012999899,
-0.03520386,
-0.015210218,
-0.01925463,
-0.025556391,
0.012872252,
0.014027798,
-0.04305083,
0.012583365,
0.003244936,
-0.05194585,
0.017736295,
-0.025959488,
0.015640188,
-0.020128008,
0.017709423,
0.0070676454,
-0.009560132,
-0.010755989,
-0.013712038,
-0.0008834557,
0.007746193,
0.025462335,
0.011488283,
-0.029049903,
-0.009902765,
0.0035170268,
0.0130200535,
-0.027786864,
-0.03547259,
0.019348687,
0.018448435,
-0.0043736096,
-0.021753836,
0.005210037,
-0.025072673,
0.014242783,
-0.020571416,
-0.011253143,
0.01212652,
0.0020574776,
-0.025959488,
0.025704192,
-0.013154419,
0.022116624,
0.001500699,
-0.008384431,
-0.0051932414,
-0.00071339885,
-0.011058312,
0.017454127,
0.009916202,
0.022304736,
-0.030044211,
0.001272277,
0.004383687,
-0.0035606958,
-0.0132283205,
-0.010991129,
-0.005025284,
0.037380587,
-0.013302222,
-0.00048287737,
0.01256321,
-0.0039637936,
0.0038495825,
0.012186985,
0.0016510207,
-0.004225807,
-0.018609675,
0.016647933,
0.0408741,
0.018246887,
0.00511934,
0.00240179,
-0.022613777,
0.005008488,
-0.05095154,
-0.027356893,
-0.010070723,
-0.04823735,
-0.013302222,
0.005142854,
0.014417459,
0.0074237147,
-0.011770451,
0.0057575777,
-0.023419973,
0.0061304434,
-0.02225099,
0.039154217,
0.007840249,
0.009204063,
-0.046087496,
-0.017171958,
-0.01082989,
-0.023299044,
0.018125957,
-0.041142832,
-0.03130725,
-0.010366327,
-0.0072759124,
0.03824053,
0.020302685,
-0.013026772,
0.0039066877,
0.005582902,
0.01169655,
0.024777068,
-0.017575057,
-0.006946716,
-0.007813375,
-0.006630956,
-0.015573005,
-0.019939896,
-0.011797324,
0.0155192595,
-0.029479874,
0.017131649,
-0.0122676045,
-0.043883897,
-0.015062415,
0.018206576,
-0.010695524,
-0.012139957,
-0.0020809916,
-0.015505822,
-0.013463461,
0.0127311675,
-0.009150316,
-0.0024740119,
-0.013987488,
0.0067317304,
0.0051327767,
0.039476696,
-0.0136247,
-0.019899586,
0.013651573,
-0.03842864,
-0.023325916,
-0.014874303,
-0.038455516,
0.04686682,
0.027813736,
-0.016191088,
-0.025784813,
-0.008989077,
-0.015290837,
-0.022654086,
0.00062564114,
-0.004548285,
0.01929494,
0.022062877,
0.000279649,
0.010373046,
-0.0058381977,
0.0073229405,
0.0042022928,
-0.026281966,
0.017507873,
-0.017870663,
0.017319761,
-0.01248259,
-0.009553414,
-0.006520104,
0.035606958,
-0.0043299403,
-0.00054754096,
0.029049903,
-0.015344583,
0.0052167554,
-0.01023868,
0.02690005,
0.016406074,
0.003520386,
0.0065268227,
-0.0038932513,
-0.0057206275,
-0.00385966,
-0.008619571,
-0.00523691,
0.017037593,
0.0052772197,
0.0034935127,
0.009741526,
-0.023164678,
-0.019872714,
0.015667062,
-0.0014906215,
0.006164035,
-0.003933561,
-0.012220576,
0.007450588,
0.007752911,
-0.008753937,
0.0035707732,
-0.0076252636,
-0.030447308,
-0.00081375334,
-0.006856019,
-0.005189882,
0.004111596,
0.0067485264,
0.019053081,
-0.011703268,
-0.013382842,
-0.020208629,
-0.020423613,
-0.024400843,
0.03552634,
0.0147265,
-0.0035338227,
-0.019066518,
-0.0060296687,
0.00032625714,
-0.02082671,
0.01169655,
-0.0027158703,
-0.0012059337,
-0.017507873,
-0.023514029,
-0.032220937,
-0.011387508,
0.002260706,
-0.02268096,
-0.010117751,
-0.015586442,
0.16715115,
-0.0087740915,
-0.0103932,
0.0046121087,
-0.026013235,
-0.006906406,
0.01146141,
0.0096541885,
0.005102544,
0.0014797043,
0.006080056,
-0.008518796,
-0.016768862,
0.0038227092,
0.025193602,
-0.0075916722,
-0.0025899024,
-0.024817377,
-0.02685974,
-0.025623573,
0.03087728,
-0.011978718,
0.016822608,
0.015465513,
0.017588494,
0.010722397,
-0.029775478,
0.011757014,
0.0044643064,
0.028001849,
-0.024481462,
0.012509463,
-0.014713064,
-0.010265553,
-0.010809735,
-0.0061438796,
-0.00063907774,
0.007820094,
0.016553877,
0.023379663,
0.0070273355,
-0.0070878,
-0.004323222,
0.014377149,
-0.008740501,
0.016983846,
0.026201347,
0.0008435658,
0.017413817,
-0.012637111,
-0.045469414,
0.014672754,
0.024185859,
0.0054922053,
0.012623674,
-0.006264809,
0.023285607,
0.016244834,
0.012139957,
0.04020227,
-0.025395151,
0.0016904908,
-0.021417921,
0.03343023,
-0.014538388,
0.028969284,
-0.014444332,
-0.022694398,
0.024911433,
-0.02055798,
0.010332736,
-0.027625624,
-0.007726038,
0.00882112,
-0.0014855828,
0.008599416,
0.04224463,
0.04224463,
0.009513104,
0.007773066,
-0.0072826305,
0.02961424,
-0.03200595,
-0.003631238,
-0.0014142009,
-0.014484642,
0.027598752,
0.015129598,
-0.0005886905,
-0.02996359,
-0.008250065,
-0.01378594,
-0.0072557577,
-0.011434536,
0.013685165,
-0.016647933,
-0.005535874,
0.021847893,
0.0013722115,
-0.0013974052,
-0.007060927,
0.041438438,
0.018260323,
0.015667062,
-0.012711012,
-0.007826813,
-0.005485487,
0.012113084,
-0.019738348,
-0.016728552,
-0.016661368,
-0.026174473,
0.014471205,
-0.0023329277,
0.011924972,
0.023325916,
0.011864508,
-0.012549773,
0.029748606,
-0.007840249,
-0.009889329,
-0.024777068,
0.010897073,
0.0130738,
-0.008895021,
0.0038462232,
-0.026550697,
0.009828864,
-0.016527003,
-0.03587569,
-0.0030585034,
-0.00771932,
0.015707372,
0.009801991,
-0.013235039,
-0.006211063,
0.010655214,
-0.009116725,
-0.02543546,
0.001200895,
0.0041552647,
0.0032986824,
0.013174575,
0.0067787585,
-0.0016510207,
-0.002106185,
0.012012309,
0.036655013,
-0.016123906,
-0.033242118,
-0.009022669,
-0.03681625,
-0.015143035,
-0.03291964,
0.018152831,
-0.02370214,
-0.015505822,
-0.03348398,
-0.0008431459,
-0.013248475,
-0.027652498,
0.015250527,
0.019886151,
0.002369878,
0.012784913,
-0.020692345,
-0.16983847,
0.014000924,
0.019308377,
-0.00827022,
0.0052671423,
0.009358583,
0.0098154275,
-0.009842301,
-0.0062984005,
0.01925463,
0.007927587,
-0.028646806,
-0.046409976,
-0.014229347,
-0.0067989137,
0.00972809,
-0.010876918,
0.035929438,
0.016889792,
0.00637902,
0.021726962,
-0.016688243,
0.02894241,
0.0047733476,
0.0051831636,
0.025529517,
-0.0074237147,
0.002524399,
0.011743578,
-0.037031237,
-0.0244949,
-0.0027780146,
0.028136214,
0.0028838278,
0.017319761,
-0.016083596,
-0.019899586,
-0.045146935,
0.0046457,
0.011924972,
0.024468027,
0.025623573,
0.004706165,
-0.005166368,
0.015250527,
0.04603375,
-0.0037857587,
-0.008881585,
0.027786864,
-0.0185828,
0.01760193,
-0.004538208,
0.0039302018,
0.026241656,
0.006080056,
0.019792095,
0.005498924,
0.011871225,
0.0016468219,
0.019724911,
0.012576646,
-0.010601467,
0.030151702,
-0.013523926,
0.01476681,
-0.031844713,
0.005693754,
0.013107391,
-0.023419973,
0.0061338022,
-0.01146141,
-0.027020978,
0.018649984,
-0.04882856,
0.043776404,
0.015304274,
-0.0011555465,
-0.011790606,
-0.011414382,
-0.005072312,
-0.011830916,
0.051327765,
-0.01059475,
-0.04189528,
-0.0041250326,
0.0016678164,
0.02272127,
0.02047736,
0.017655676,
0.0021968822,
0.009768399,
-0.012724449,
0.005653444,
-0.024185859,
0.024897998,
0.024038056,
-0.02733002,
-0.019630855,
0.0061539575,
-0.0066007236,
0.0371656,
-0.0050353613,
-0.0073296586,
-0.00088261586,
0.029453,
0.00080241624,
-0.025448898,
0.005203319,
0.03721935,
-0.0069399974,
0.003883174,
-0.0015233732,
0.017145086,
0.038348023,
-0.00015263124,
0.007269194,
0.0009363622,
-0.002012129,
0.013799376,
-0.043964516,
0.065033086,
-0.0026486875,
-0.011293452,
0.008129136,
-0.009781836,
-0.021162625,
-0.12909874,
-0.044125754,
0.0032902844,
0.021874765,
-0.00053452427,
-0.0026822789,
-0.0056568035,
0.040712863,
0.007934305,
0.03673563,
-0.018730603,
-0.023419973,
-0.008895021,
-0.013879995,
-0.007605109,
0.015586442,
0.015546132,
-0.014780247,
-0.020396741,
0.021673216,
-0.027625624,
0.0038294275,
-0.012428843,
-0.009969948,
0.007746193,
0.009795273,
-0.027128471,
0.043453924,
0.013208166,
0.0036413153,
-0.012401971,
0.0009733128,
-0.0006907246,
-0.0026621239,
-0.01378594,
-0.007813375,
0.0011488283,
-0.014632444,
0.033994567,
-0.012516182,
0.019066518,
0.013879995,
0.017225705,
-0.0061203656,
-0.008740501,
0.020571416,
-0.011400945,
-0.0023480437,
0.0074640247,
0.0026386098,
-0.024239605,
-0.01768255,
0.007705883,
-0.006372302,
0.039396077,
-0.009929638,
0.015774554,
0.0016518605,
-0.017024158,
0.0051159807,
0.003429689,
0.003678266,
-0.005163009,
0.010614905,
0.026040107,
-0.007752911,
-0.029856099,
-0.027598752,
0.013617982,
-0.035580084,
-0.017427254,
0.048452336,
-0.008962204,
0.0028922255,
-0.01562675,
0.017145086,
-0.009781836,
0.00026705218,
-0.00019630016,
-0.0027427436,
-0.008142572,
-0.026214782,
0.02961424,
-0.0072154477,
0.013456743,
-0.0069601526,
0.011750296,
-0.0008700191,
0.00937202,
0.0028418384,
-0.011018002,
0.03512324,
0.0053813537,
-0.008700191,
-0.021726962,
0.014981795,
0.0048573264,
-0.025207039,
-0.008122417,
0.024266478,
-0.03689687,
-0.010164779,
-0.053074524,
0.0041720606,
0.00020207369,
-0.0051529314,
-0.0035405408,
-0.007820094,
0.014619008,
-0.00689297,
-0.009875892,
-0.0073901233,
-0.021404484,
0.0148474295,
-0.0043467362,
-0.007242321,
-0.02043705,
-0.024562083,
0.0312535,
-0.010252116,
0.020450488,
0.02894241,
0.0006277406,
0.015693935,
0.017037593,
0.02204944,
-0.023299044,
0.00177195,
-0.04831797,
0.029909845,
0.0046188273,
-0.0065637734,
0.0025999798,
-0.02902303,
-0.0033255555,
0.004296349,
0.019509926,
-0.004561722,
0.005374635,
0.023003438,
0.018959025,
0.026604444,
-0.003654752,
-0.0312535,
0.0058852257,
0.00417542,
-0.014148727,
-0.015425203,
-0.035418846,
0.0015149753,
0.029721733,
-0.009123444,
0.028996157,
-0.0017937844,
0.0019180729,
-0.047189295,
-0.017749732,
-0.0012160112,
0.0031911896,
-0.0026772402,
0.0049916925,
-0.0152639635,
0.02886179,
0.004507975,
-0.0009497988,
-0.01929494,
-0.022895945,
-0.01590892,
-0.03248967,
0.017024158,
-0.013268631,
-0.009069697,
-0.01598954,
0.016728552,
0.01629858,
-0.0037790404,
-0.007907432,
0.014323403,
-0.024803942,
0.015734244,
-0.0018542492,
-0.001011943,
0.021888202,
-0.0055627474,
-0.026752247,
0.017198833,
0.019886151,
-0.004027617,
-0.0046591368,
0.040121652,
-0.010191652,
0.027020978,
0.009795273,
0.02784061,
0.0053141704,
0.003886533,
0.00029644472,
0.0048841997,
-0.010856763,
-0.00012103427,
0.0030601828,
0.019523362,
-0.017239142,
-0.0032231016,
-0.0013050286,
-0.02437397,
-0.0055157193,
0.006305119,
-0.045496285,
-0.012213859,
-0.015935794,
0.015532696,
0.013080519,
-0.017790042,
0.014901176,
0.0029560493,
-0.0004560042,
0.004020899,
-0.0064394847,
0.006009514,
-0.008411304,
0.03445141,
0.0025680677,
-0.0016081916,
0.0070878,
0.001862647,
-0.01279835,
-0.000586591,
0.025865432,
-0.028512439,
0.017158523,
-0.012885688,
0.024736758,
-0.03157598,
-0.007544644,
-0.02000708,
-0.006879533,
-0.014511515,
0.007316222,
0.01562675,
-0.010426792,
0.09975323,
0.0047263196,
-0.001232807,
0.012314633,
-0.019281503,
0.010319299,
-0.0064865127,
0.0053175297,
-0.029318634,
-0.029130522,
0.00842474,
-0.026040107,
0.025422024,
0.0062513724,
-0.031360995,
0.013214884,
-0.01248259,
0.010561158,
0.004390405,
-0.032220937,
0.021391047,
-0.02598636,
0.01023868,
0.025892304,
-0.010339455,
-0.029856099,
0.025395151,
-0.008995796,
0.0030232323,
-0.00913688,
0.04380328,
-0.015882047,
-0.042755224,
-0.018327506,
-0.006698139,
-0.015129598,
-0.01027899,
-0.013450025,
-0.0068862513,
0.02792123,
-0.015465513,
0.015411766,
-0.023245297,
-0.004259398,
-0.008330684,
-0.016983846,
-0.008599416,
-0.025018927,
-0.03587569
] |
OBJECT Awake craniotomy was performed as the standard surgical approach to supratentorial intraaxial tumors, regardless of the involvement of eloquent cortex, in a prospective trial of 200 patients surgically treated by the same surgeon at a single institution. METHODS Patient presentations, comorbid conditions, tumor locations, and the histological characteristics of lesions were recorded. Brain mapping was possible in 195 (97.5%) of 200 patients. The total number of patients sustaining complications was 33 for an overall complication rate of 16.5%. There were two deaths in this series, for a mortality rate of 1%. New | [
0.0052872817,
0.0241512,
0.029428385,
-0.027624449,
-0.012405424,
0.015387303,
-0.0045165704,
-0.0018325429,
-0.014794966,
0.00015355331,
0.012553508,
0.025147403,
0.011469801,
0.018793242,
-0.009403352,
0.016800834,
0.029589932,
-0.00026650963,
-0.031016925,
-0.013987234,
-0.028997594,
0.0035876783,
0.005512774,
0.008063862,
-0.0033234823,
-0.0031636187,
0.007841736,
-0.02891682,
0.0145122595,
-0.011214019,
0.0010769765,
-0.0050180377,
-0.022428038,
0.0018039357,
-0.0075724917,
0.00570461,
0.0165989,
-0.017904736,
-0.0009398303,
0.005145929,
0.0195202,
-0.004307906,
0.014673806,
-0.0033739656,
-0.016006565,
0.001663424,
-0.030101495,
-0.028836047,
-0.0070945835,
0.0021505875,
0.007027272,
0.054360393,
-0.036374886,
0.023949267,
0.004593978,
-0.024662765,
0.0016827759,
0.02275113,
0.016612364,
-0.025039706,
0.022912677,
-0.01243908,
-0.017298937,
0.013576636,
-0.01817398,
0.007619609,
0.014444948,
-0.012169835,
-0.013240081,
-0.015508463,
0.057725944,
0.043456007,
-0.014646881,
-0.02164723,
0.029105293,
-0.006458494,
-0.021512607,
-0.022037633,
0.012816021,
0.022481887,
0.016477741,
-0.034301706,
-0.008063862,
0.032228526,
0.016181573,
0.008736973,
-0.0069330367,
0.02835141,
-0.020570252,
0.0025931576,
-0.019870218,
0.0058156736,
-0.00387375,
-0.0021034698,
-0.013650678,
0.044963773,
-0.0042978097,
0.021189515,
-0.0058998126,
-0.037182618,
-0.0071686255,
0.0043381965,
-0.029589932,
-0.022172255,
-0.0069801547,
0.00343118,
0.018523997,
0.016908532,
0.015670009,
-0.010056268,
0.010089925,
0.018510535,
0.0076128785,
-0.021485683,
-0.00086158124,
0.0008544295,
0.015750783,
0.013670872,
-0.012190029,
0.011483263,
0.024568528,
0.00030247896,
0.036509506,
-0.02750329,
-0.0018258119,
-0.004701676,
-0.015050747,
-0.013091996,
0.0145122595,
-0.0333055,
0.001416056,
0.006593116,
0.030451514,
-0.001524595,
0.014916126,
0.014566109,
-0.010641875,
0.023881955,
-0.022347264,
-0.058372132,
0.011139977,
0.016396968,
0.006024338,
-0.008487922,
-0.014579571,
0.02543011,
0.02610322,
0.021068355,
-0.0031821292,
-0.009504318,
-0.004671386,
-0.014000695,
0.0047420627,
0.0068051456,
0.01140922,
-0.0046882136,
0.015791168,
0.042944442,
-0.016827758,
-0.009988958,
-0.03939042,
-0.00387375,
-0.0044526253,
0.0044257008,
0.008131173,
0.008858132,
0.00615896,
-0.010776497,
0.0055598915,
-0.017581644,
0.0021590015,
0.027059037,
-0.022091482,
0.0067613935,
0.0047790837,
-0.008885057,
-0.003190543,
0.015171908,
-0.04165207,
-0.032416996,
-0.02055679,
-0.004068952,
0.001021445,
0.020529866,
-0.024528142,
-0.0047723525,
0.018766318,
-0.0032056882,
-0.002673931,
-0.006855629,
0.006381086,
0.042621348,
-0.012486197,
-0.005233433,
-0.6392933,
-0.024783924,
0.014444948,
-0.027153272,
0.03500174,
0.02848603,
-0.017473945,
0.00049936376,
-0.014498797,
0.012210222,
-0.019008636,
0.022953063,
0.017460482,
-0.02641285,
-0.010850539,
-0.016437355,
0.0033588207,
0.0062666577,
-0.009228343,
-0.016706599,
-0.006428204,
0.013852611,
-0.020866422,
0.02629169,
-0.005337765,
0.021997247,
0.0165989,
-0.027785996,
-0.0034564217,
-0.008366762,
-0.010783228,
0.030774606,
-0.0056911483,
0.0037458593,
0.044129115,
-0.02219918,
-0.031528488,
0.010392824,
0.007666727,
0.040036604,
0.011187094,
-0.043644477,
0.038771156,
-0.0017585008,
-0.04038662,
0.01067553,
0.0018140324,
-0.012331382,
-0.014323789,
-0.026587859,
0.019170184,
0.009840874,
-0.022589585,
0.0022801613,
0.0030996732,
-0.015118059,
0.02372041,
-0.014418024,
0.0075186426,
0.0031400598,
-0.0049238023,
-0.0008918712,
-0.012560239,
-0.015091134,
-0.026022447,
0.04033277,
-0.0068455325,
0.009033141,
0.02024716,
-0.00027597524,
0.020718338,
0.018699005,
0.014296864,
-0.009080259,
0.016275808,
0.015616161,
0.0057180724,
-0.0068017803,
-0.0172047,
-0.00063314446,
0.0043314653,
0.0037525904,
-0.037748028,
0.0009280509,
0.0005111432,
-0.024999319,
-0.020166386,
0.007888854,
-0.0020714973,
-0.017823962,
0.010749573,
0.018550921,
0.003251123,
-0.028189862,
-0.0012141229,
0.007417676,
0.003350407,
0.00081993255,
0.046148445,
-0.004799277,
0.0017972047,
-0.014175705,
0.00076566305,
0.0064080106,
0.013267005,
0.01744702,
-0.017756652,
-0.0006630137,
0.060364537,
-0.018887477,
-0.016195035,
0.0025510883,
0.00295832,
-0.014552646,
0.018254753,
-0.023922343,
-0.009544705,
0.012250609,
-0.023801183,
-0.012943912,
0.012190029,
0.001329393,
0.022010708,
-0.01128133,
0.01737971,
-0.0004392045,
0.0047588903,
-0.014929588,
-0.009827412,
-0.0064786873,
0.00043457688,
-0.024851235,
0.0013302343,
-0.01060822,
0.006505612,
-0.009874529,
-0.0032544886,
-0.037801877,
-0.021068355,
-0.016289271,
-0.031420793,
-0.0014850497,
0.016316196,
0.020651026,
-0.030020723,
-0.01079669,
-0.008824477,
0.009712983,
0.0005683576,
-0.001854419,
0.03195928,
-0.008831208,
-0.011786163,
0.0041429945,
0.02598206,
-0.0034412767,
-0.0025342605,
-0.029347612,
-0.00024463356,
-0.021889549,
0.0017517697,
0.035540227,
-0.0040252,
0.009315847,
0.0012115986,
-0.029697629,
-0.018900938,
0.002906154,
-0.0053714206,
-0.04415604,
-0.0018981713,
-0.010069731,
0.018456686,
0.012506391,
-0.013765107,
0.012250609,
-0.000882616,
-0.008366762,
0.02390888,
0.0067647593,
0.0028573535,
0.030289967,
-0.0035876783,
-0.0045838817,
0.00074504904,
0.019224033,
0.004678117,
-0.0013723038,
-0.009214881,
0.0139199225,
0.0029448578,
0.019116335,
-0.02116259,
0.005751728,
0.0032948751,
0.016356582,
0.018268215,
0.00310977,
-0.0076398025,
0.03325165,
0.04243288,
0.008366762,
0.027651373,
0.01853746,
0.0414636,
-0.008285989,
0.0068388013,
-0.0016735207,
-0.00713497,
-0.02629169,
-0.016841222,
-0.017110465,
0.0069195745,
-0.011988096,
0.004038662,
0.018847091,
0.02670902,
-0.012950644,
-0.012540046,
0.0014337251,
0.006583019,
0.004506474,
0.0014110076,
0.01914326,
0.013287199,
0.013987234,
0.026520548,
0.011940978,
0.017231625,
-0.016477741,
-0.021539532,
0.027920619,
0.009921647,
0.041759767,
0.02318192,
0.0151045965,
-0.00023685071,
0.007209012,
0.014498797,
0.009134107,
0.007067659,
0.024905084,
-0.016181573,
-0.016006565,
-0.000431632,
0.017110465,
0.020893347,
-0.011483263,
0.00091711286,
0.005186315,
-0.0021741465,
-0.013576636,
0.0055666226,
0.017231625,
0.0008641054,
0.011988096,
-0.01189386,
0.025282025,
0.025658967,
0.044506058,
0.017554719,
0.0032881442,
0.011382297,
0.011759238,
-0.014606495,
-0.013617023,
0.0134218205,
-0.0032477574,
0.009356234,
-0.01603349,
-0.02726097,
-0.034974813,
0.011314985,
-0.02121644,
0.03233622,
0.0034968085,
-0.027409054,
0.038501915,
0.018523997,
0.0072561298,
-0.018564384,
-0.05605663,
0.010332244,
0.0134218205,
0.016908532,
-0.009726445,
0.0074378694,
-0.004190112,
-0.016141187,
0.028728351,
-0.0072897854,
0.0038064392,
-0.024043502,
-0.004580516,
-0.0004301596,
-0.010843808,
0.023558863,
-0.008218678,
0.00023832313,
-0.04434451,
-0.0036482583,
0.00058392325,
-0.015010362,
0.013812224,
0.007592685,
0.0004686531,
-0.017770113,
-0.021862624,
-0.007336903,
-0.0013285516,
0.017191239,
-0.02024716,
-0.009612016,
0.00082203606,
0.017487407,
0.0031821292,
-0.023195384,
0.00029848237,
0.0110524725,
0.009982226,
-0.008036938,
-0.022010708,
-0.0055396985,
-0.0008089945,
0.028459106,
0.032793935,
0.0034900773,
0.019924067,
0.017675878,
0.0054420973,
-0.02829756,
-0.005667589,
0.009430276,
-0.0020109173,
-0.015656548,
0.007511912,
0.03182466,
0.0056103747,
0.025632042,
0.013132383,
0.008757166,
-0.018187443,
-0.009544705,
-0.012062138,
-0.016477741,
0.0028741814,
0.04270212,
0.04622922,
0.00043752172,
-0.032470845,
-0.0028354775,
0.02316846,
-0.011631347,
0.005684417,
-0.020529866,
0.028593728,
0.006818608,
0.02439352,
-0.0017080175,
-0.015481538,
0.028324485,
0.008514846,
0.015562312,
-0.015239218,
0.00908699,
0.039955832,
0.02019331,
-0.008353299,
0.021970322,
-0.0252551,
0.015118059,
-0.0050079413,
-0.009181226,
-0.013536249,
-0.0015868577,
-0.0029179335,
0.0032763646,
-0.007740769,
0.014054544,
0.007202281,
-0.0044627218,
-0.012849677,
0.013744914,
0.004018469,
0.0054252697,
-0.010278395,
0.009288923,
0.0011745776,
-0.024783924,
-0.033709366,
-0.016020026,
-0.0014665392,
-0.023276156,
-0.008158098,
-0.00023621967,
-0.01402762,
-0.04964862,
0.008959099,
0.025955135,
0.008736973,
0.011321716,
-0.02048948,
-0.0069128433,
0.01494305,
-0.012062138,
-0.005196412,
-0.011442876,
-0.0070945835,
0.013825687,
-0.009766831,
-0.0062599266,
-0.012156373,
0.00048674294,
0.018066281,
0.020718338,
-0.0018931229,
0.0129775675,
0.006508977,
0.016383506,
-0.001945289,
0.012519853,
0.022495348,
-0.015373841,
-0.02420505,
0.0043449276,
-0.025012782,
-0.022428038,
-0.01103901,
0.011799625,
-0.0062363674,
0.015818093,
0.019224033,
-0.00847446,
-0.003853557,
-0.0026772965,
-0.0076061473,
0.0010063,
0.0003420242,
0.0058897156,
0.01694892,
0.0058392324,
0.030693833,
0.014485335,
0.020974118,
-0.0017315764,
0.00713497,
0.01694892,
-0.0022566025,
-0.031447716,
0.01012358,
-0.00019520201,
-0.0068859193,
-0.019789444,
-0.0155488495,
-0.010971699,
0.02318192,
0.021741465,
-0.00003802022,
-0.0018561018,
-0.028997594,
-0.009632209,
0.02121644,
-0.029374536,
0.010419749,
-0.020260623,
0.013610291,
-0.028755276,
-0.01372472,
-0.021149127,
-0.026183993,
-0.0129775675,
0.029105293,
-0.025470497,
0.0009793756,
-0.0038602878,
0.0036078715,
-0.021660691,
-0.016679674,
-0.017245088,
-0.03527098,
-0.0025174327,
-0.002320548,
0.04768314,
-0.0190221,
0.033870913,
0.027355205,
0.02567243,
0.0151045965,
-0.00070171757,
0.015387303,
-0.005903178,
-0.0011720534,
-0.017473945,
0.008016745,
-0.018348988,
0.004964189,
0.016693138,
0.0021522704,
0.016854683,
0.018133594,
-0.024110813,
-0.01231792,
-0.0118669355,
-0.037667256,
-0.01641043,
0.012176567,
0.011759238,
0.0024013212,
-0.034059383,
0.017702803,
0.025268564,
0.020704875,
-0.0012856408,
-0.012351575,
0.02945531,
-0.008662931,
-0.02017985,
0.0017551353,
0.015346916,
0.0064786873,
-0.0018308602,
0.0064517627,
0.00198231,
0.0028035047,
0.0050449623,
0.019950991,
0.027180197,
-0.012371768,
-0.022347264,
-0.0030677004,
-0.017864348,
0.0059334678,
-0.009490856,
-0.017487407,
-0.007458063,
-0.011119783,
-0.01262082,
-0.007397483,
-0.003235978,
0.0107024545,
-0.0066335024,
0.026587859,
-0.017473945,
-0.016773911,
0.016275808,
-0.027476365,
0.039982755,
-0.01506421,
0.02592821,
0.007397483,
-0.0036179682,
0.0039040402,
0.006142132,
-0.021754928,
-0.0137853,
-0.00084265,
0.017595105,
0.0070407344,
-0.0033470413,
-0.0096658645,
0.024851235,
-0.036940295,
-0.045825355,
0.011564036,
0.0064181075,
0.002921299,
-0.028378334,
-0.032120828,
-0.019116335,
0.042782895,
-0.0013739865,
-0.0032931925,
-0.0014808428,
-0.012338113,
-0.018712468,
0.015629623,
-0.010056268,
0.004422335,
0.0074782562,
0.014619957,
-0.0043348307,
-0.006014241,
-0.016275808,
-0.0010391141,
0.013179501,
0.0025342605,
-0.034678645,
0.020476017,
-0.0013605243,
0.005135832,
-0.012082331,
-0.010130311,
-0.011745776,
0.035351757,
-0.0036751826,
-0.019587511,
0.015723858,
0.009874529,
0.0004087042,
-0.005940199,
-0.0022465058,
-0.0025695988,
0.004355024,
-0.011880398,
0.03629411,
0.0068455325,
-0.014068007,
-0.023060761,
-0.013765107,
-0.005862791,
-0.0041328976,
-0.007922509,
0.005543064,
-0.026614783,
0.015010362,
0.01824129,
0.009053335,
0.016020026,
0.011335178,
-0.00044467353,
0.004708407,
0.016639289,
-0.025699355,
-0.022118406,
0.02738213,
0.0039915442,
-0.016935457,
0.000569199,
-0.0036549892,
-0.023478089,
0.022899214,
-0.011065935,
-0.029186066,
-0.022414574,
0.005970489,
0.0148084285,
0.0028573535,
-0.0010063,
0.016814297,
0.009719714,
0.015360379,
0.0018039357,
-0.03823267,
0.013765107,
-0.021377984,
-0.007996551,
0.0074378694,
-0.0140141575,
-0.010574563,
-0.00399491,
0.021566456,
0.024528142,
-0.053148795,
0.006074821,
-0.0054555596,
0.027462903,
-0.008097517,
-0.0030963076,
0.002118615,
-0.0120756,
-0.022172255,
0.0041732844,
-0.009039872,
-0.020839497,
0.0017416731,
-0.010695724,
-0.01817398,
0.004866588,
-0.02993995,
0.000272189,
0.021754928,
-0.029347612,
-0.03799035,
0.00033297928,
-0.017150853,
0.033036258,
0.028701426,
0.0008594778,
-0.014902663,
-0.02921299,
-0.045044545,
0.024972394,
-0.0010248105,
0.024662765,
0.024501218,
0.027530214,
-0.010877464,
0.0011527016,
-0.019237494,
0.016639289,
-0.014673806,
0.0046478272,
0.009558167,
-0.010722648,
0.0045704194,
-0.02226649,
-0.013637216,
-0.01915672,
-0.0019250957,
0.0009095404,
-0.018739393,
0.017460482,
0.008440804,
-0.011469801,
-0.0071820877,
0.000017918934,
-0.0003214102,
0.017406635,
-0.01658544,
-0.013892998,
0.024797386,
-0.0063777207,
0.007458063,
0.0011922467,
-0.0014446632,
0.01402762,
0.0050113066,
0.018227829,
-0.012432349,
-0.02061064,
0.025645506,
-0.036563355,
0.009376427,
0.012068869,
0.0060075102,
0.0072965166,
0.0035102705,
-0.017285474,
-0.0015868577,
0.007707114,
-0.016073875,
-0.020987581,
0.006391183,
-0.033924762,
0.0023693484,
0.00932931,
0.019991377,
-0.020166386,
0.0015885405,
-0.00884467,
-0.00031257563,
-0.016666213,
0.017298937,
0.008285989,
-0.04318676,
-0.00009770618,
0.007350365,
-0.04030585,
-0.008743703,
-0.0155488495,
-0.004159822,
-0.03591717,
0.02031447,
-0.020704875,
0.010924581,
0.00023958522,
0.0073301718,
0.010567833,
-0.029697629,
0.016195035,
0.17307013,
-0.0045636883,
-0.028216787,
0.0013386483,
-0.004183381,
-0.013071803,
0.03610564,
0.0017685975,
-0.016154649,
0.022603046,
0.010789959,
-0.012694862,
-0.022885753,
0.0045333984,
0.016962381,
-0.012876601,
-0.019170184,
-0.021956861,
-0.008683124,
-0.011846743,
0.014121856,
-0.0070474655,
0.010386093,
0.00009339406,
0.000374628,
-0.016571978,
-0.014539184,
-0.0019318267,
0.024433907,
0.00028186495,
-0.005341131,
0.016275808,
0.0084071485,
0.0044257008,
-0.032470845,
0.004624268,
-0.012344844,
0.004307906,
0.00095329253,
-0.0068455325,
-0.014162242,
0.0003039514,
0.018456686,
0.0038098046,
-0.014916126,
0.017662415,
0.025874363,
-0.008710048,
-0.009632209,
0.0061993464,
-0.024043502,
0.021256825,
0.0046545584,
0.004429066,
0.005378152,
-0.001546471,
0.04097896,
0.008117711,
0.0052132397,
0.014794966,
-0.01914326,
0.005196412,
-0.02598206,
0.02677633,
-0.0020513039,
0.01665275,
-0.007350365,
-0.0016987623,
0.017433558,
-0.0038838468,
0.013098728,
-0.025322411,
-0.02805524,
-0.00068194495,
0.008124442,
-0.014727655,
0.01860477,
-0.0035203672,
-0.0018359085,
0.011665002,
0.008918712,
-0.031474642,
0.020152925,
0.035594076,
-0.033467047,
-0.019547125,
0.012358306,
0.025820514,
0.019735595,
-0.004987748,
-0.017743189,
0.0051257354,
0.0022852097,
-0.026843641,
0.0072830543,
-0.017325861,
0.026305154,
0.03239007,
-0.024905084,
0.0039545232,
-0.025026243,
0.050644822,
0.015898867,
-0.0025022877,
-0.0039376956,
0.00847446,
-0.01914326,
0.028270636,
0.025443573,
-0.006872457,
0.016289271,
-0.011483263,
-0.0059132744,
0.0052065086,
0.026857104,
0.02835141,
-0.031636186,
-0.009282192,
0.013778569,
-0.018025896,
0.0036280649,
-0.0424598,
0.00089944375,
0.03397861,
-0.0044526253,
-0.025551269,
-0.025457034,
-0.009699521,
0.018147055,
-0.036751825,
0.01140922,
-0.013731452,
-0.012741979,
0.0048531257,
0.014243015,
-0.025174327,
-0.002747973,
-0.007505181,
-0.012762172,
0.0056574927,
0.006330603,
0.0060176067,
0.025416648,
0.012062138,
-0.010083193,
0.0054555596,
0.008454266,
0.001659217,
0.0073099784,
-0.009470663,
-0.02421851,
-0.02366656,
0.011564036,
0.009834142,
0.021754928,
-0.027893694,
-0.013650678,
-0.01737971,
-0.021027967,
0.03836729,
-0.030047648,
0.017514331,
0.02591475,
-0.025726277,
-0.011173632,
0.004708407,
-0.1703777,
0.00002844943,
0.013468939,
-0.037640333,
0.044129115,
-0.00010333296,
0.0264667,
-0.016545054,
-0.009867798,
-0.0038266324,
0.013394896,
0.015804632,
-0.02891682,
-0.018618234,
0.01061495,
-0.004072318,
-0.0061387667,
0.025093554,
0.0053142062,
0.018402837,
-0.0009213198,
-0.015575774,
0.03287471,
-0.0021977054,
0.004429066,
0.0073099784,
-0.006939768,
0.014175705,
0.015198832,
-0.039175022,
-0.013879536,
-0.01402762,
0.029186066,
-0.008131173,
0.0028506224,
0.0017585008,
-0.014081469,
-0.023828108,
-0.023505013,
0.009006217,
-0.010291858,
0.027355205,
0.012371768,
0.002710952,
-0.017514331,
0.029859176,
0.042109784,
-0.011294792,
0.021458758,
-0.021903012,
0.022454962,
-0.01262082,
-0.022374189,
0.02945531,
0.018550921,
0.010951506,
0.021687616,
-0.011665002,
0.0026183992,
-0.016087338,
-0.016975844,
-0.028997594,
0.0047689867,
-0.0020311105,
-0.03104385,
-0.044371434,
-0.0031518394,
-0.010648606,
-0.011005354,
0.0165989,
-0.028512955,
-0.0008733607,
-0.0023861763,
-0.0435637,
-0.004782449,
0.012068869,
-0.0019351923,
0.016275808,
0.0024989222,
-0.01829514,
-0.0011678465,
0.004715138,
-0.0172047,
-0.014431486,
-0.011415952,
-0.012943912,
0.000067889494,
0.025403185,
0.02152607,
-0.019506738,
-0.0043146373,
-0.021929936,
-0.012762172,
-0.0054925806,
0.003453056,
0.04859857,
-0.014350713,
-0.0012334747,
-0.0000050811946,
-0.0121631045,
0.008036938,
-0.0012048675,
-0.023962729,
0.0043718517,
0.022454962,
-0.02689749,
0.0101841595,
0.026493624,
0.020449093,
0.007188819,
-0.0071753566,
0.009127377,
0.014741117,
-0.00878409,
-0.002290258,
0.027543677,
-0.023733871,
0.0058156736,
0.0033520896,
0.013442014,
0.061872303,
-0.00829272,
-0.011018816,
-0.013744914,
-0.0053680553,
0.012560239,
-0.11469801,
-0.016975844,
0.00257633,
0.0105543705,
0.003101356,
0.006556095,
-0.016989306,
0.02848603,
-0.035621002,
0.049244754,
-0.037667256,
-0.025847439,
-0.0032410263,
-0.019183645,
0.016612364,
-0.009127377,
0.0046747513,
-0.012216954,
0.0057483627,
0.042782895,
-0.0022111675,
0.007855198,
0.012358306,
-0.048840888,
-0.037047993,
-0.0016255615,
-0.02055679,
0.017460482,
0.011005354,
0.021458758,
0.004782449,
-0.016020026,
0.015535387,
0.012486197,
0.019856757,
0.019116335,
-0.023249231,
-0.028889896,
0.020422168,
-0.01634312,
-0.0037626869,
0.023518477,
0.01445841,
0.023101147,
0.00530411,
0.004122801,
-0.041732844,
-0.0053343996,
0.008346569,
0.002132077,
-0.0053714206,
-0.02530895,
0.0050113066,
-0.007713845,
-0.015239218,
-0.0023020376,
0.0042944443,
-0.007888854,
0.003927599,
0.013139115,
0.015171908,
-0.002238092,
-0.015925791,
0.02786677,
0.029966874,
-0.009053335,
-0.016518129,
-0.024487754,
-0.011947709,
-0.0015725541,
-0.023491552,
0.039982755,
-0.013388165,
-0.015845018,
-0.029051444,
-0.016154649,
-0.0148084285,
-0.01159096,
0.009612016,
-0.017891273,
-0.009645672,
-0.015279605,
0.008312913,
-0.013516056,
0.0030979905,
0.020085614,
-0.0069734235,
-0.01542769,
0.030397665,
-0.027005188,
0.03171696,
0.01976252,
0.006142132,
-0.025726277,
0.0018426396,
0.0066806204,
-0.0042506917,
-0.003944427,
0.0065594604,
0.019937528,
-0.018766318,
-0.013145845,
-0.046956178,
0.022172255,
0.010574563,
-0.0038266324,
0.002793408,
0.016827758,
0.022091482,
-0.0038030737,
-0.0029044712,
-0.0069330367,
-0.019977916,
-0.0049709203,
-0.026991725,
0.009457201,
-0.024851235,
-0.032040052,
0.0067546624,
-0.02262997,
0.012876601,
0.03214775,
0.01597964,
0.012816021,
0.0095177805,
0.0165989,
-0.0037727836,
0.005219971,
0.011247674,
0.039121173,
-0.012937182,
0.005792115,
0.0029027883,
-0.026305154,
0.0020142829,
0.03624026,
-0.0019351923,
-0.036078714,
0.021310674,
0.0070474655,
0.023895418,
0.032416996,
-0.03688645,
-0.0172047,
0.029751478,
-0.018268215,
-0.006872457,
0.014000695,
-0.007592685,
0.02171454,
0.004422335,
-0.01860477,
0.01872593,
-0.007882122,
-0.0059368336,
-0.008804284,
-0.025026243,
0.02641285,
-0.008676393,
-0.011739044,
-0.0025393087,
-0.007336903,
0.044506058,
-0.003318434,
0.00024189903,
-0.0080504,
0.016720062,
-0.016491205,
-0.015023824,
-0.009228343,
0.0063036787,
-0.029670704,
-0.020826034,
-0.00012568233,
0.009315847,
0.018941326,
0.0018224464,
-0.0029499063,
-0.009235074,
0.030909227,
-0.018227829,
0.025632042,
0.018510535,
-0.004422335,
0.0029667339,
0.012432349,
0.012109255,
0.001648279,
-0.03190543,
0.034678645,
-0.016248884,
-0.011463069,
-0.0022734303,
0.01518537,
0.0007707114,
0.00043668036,
-0.008023475,
0.02494547,
-0.017460482,
-0.00686236,
0.04275597,
0.011765969,
-0.004264154,
0.014283402,
-0.012284264,
-0.018820167,
-0.009477394,
-0.00052965374,
-0.02897067,
-0.022226105,
-0.016383506,
0.019816369,
0.036751825,
0.023262694,
0.014081469,
0.005149294,
-0.006636868,
-0.0112005565,
0.0022347264,
0.0025056533,
0.000075777505,
0.008629275,
0.011489994,
-0.00039397992,
0.035486378,
0.00026019922,
0.01872593,
-0.009558167,
-0.0025780126,
-0.026601322,
0.023653097,
-0.014000695,
0.029266838,
-0.0013033099,
-0.03080153,
0.0054555596,
0.005145929,
-0.037290316,
-0.007821542,
0.010749573,
-0.003493443,
0.07754231,
-0.0071080453,
-0.0050786175,
0.0028035047,
-0.017352786,
0.0007408421,
-0.0013840832,
0.002869133,
-0.0009591823,
-0.04447913,
0.0036448927,
-0.011523649,
0.026735945,
-0.031366944,
-0.034490176,
-0.0045266673,
0.0069666924,
0.04439836,
0.006704179,
-0.00466802,
0.031259246,
-0.021027967,
0.014216091,
-0.0069734235,
-0.0058829845,
0.018645158,
0.0045367638,
0.0031669843,
-0.01848361,
-0.033440124,
0.017298937,
-0.001884709,
-0.03586332,
-0.033709366,
-0.0011787845,
-0.0025107018,
-0.021310674,
-0.034436326,
-0.017675878,
0.004398776,
-0.014714193,
0.025080092,
-0.014135318,
-0.028836047,
-0.011065935,
-0.025726277,
-0.0027816286,
-0.013044879,
-0.013765107
] |
How the number of immune cells recruited to sites of infection is determined and adjusted to differences in the cellular stoichiometry between host and pathogen is unknown. Here, we have uncovered a role for reactive oxygen species (ROS) as sensors of microbe size. By sensing the differential localization of ROS generated in response to microbes of different size, neutrophils tuned their interleukin (IL)-1β expression via the selective oxidation of NF-κB, in order to implement distinct inflammatory programs. Small microbes triggered ROS intracellularly, suppressing IL-1β expression to limit neutrophil recruitment as each phagocyte eliminated numerous pathogens | [
0.004992939,
-0.01949718,
-0.01137665,
-0.03264031,
-0.014949156,
0.006653956,
0.0035131834,
0.0048380424,
-0.013683619,
-0.022436917,
0.030451985,
-0.020314505,
-0.0075075347,
0.0117194,
-0.010012244,
0.0020845109,
0.037887014,
0.0347759,
0.0017088045,
0.0062123365,
-0.03667421,
0.02068362,
-0.009629946,
-0.01796799,
0.0059453873,
0.012497178,
0.018930325,
-0.045717526,
-0.009616763,
-0.030636542,
0.012075332,
-0.0000727622,
-0.01895669,
0.0034209047,
-0.018666672,
-0.0014492706,
0.03264031,
-0.021197746,
0.022278724,
-0.011580982,
0.013670436,
0.0049369126,
-0.0034242005,
0.0114425635,
0.009623354,
0.0027848405,
-0.0009779899,
-0.008061207,
0.00689454,
0.02181733,
0.02860641,
-0.008713749,
-0.009412431,
0.0021701984,
-0.028290026,
-0.017691152,
0.0053455755,
0.0018389835,
-0.012279664,
-0.016333338,
-0.007804145,
0.004515067,
-0.021145014,
0.01974765,
-0.0013726463,
0.0050984006,
0.019114882,
0.04126178,
-0.0046304152,
0.006657252,
0.035830516,
0.01082957,
0.007428439,
0.013775898,
0.0013742942,
-0.022120532,
-0.02003767,
0.010097931,
0.015568742,
-0.0049402085,
0.007843693,
-0.014711868,
-0.014224109,
0.025178913,
0.006387007,
-0.013749532,
-0.01802072,
0.017941624,
0.0052763666,
-0.0033945395,
0.0065419036,
0.0046370067,
0.041129954,
0.0257985,
-0.0059948224,
0.02491526,
-0.028870063,
0.021105466,
-0.0012350521,
-0.024005655,
-0.009399249,
0.010869117,
-0.026259894,
-0.016096048,
-0.037491534,
-0.0008939503,
-0.004126178,
-0.008799437,
0.011047084,
0.009544258,
-0.008726932,
0.027657257,
-0.016438799,
-0.03511865,
0.021065919,
-0.0018307443,
0.011943506,
0.013564975,
-0.032376654,
-0.019787198,
0.0068615833,
0.03870434,
0.005352167,
-0.018482113,
0.033510365,
0.006390303,
0.00005242174,
-0.010954805,
-0.034327693,
-0.0024684563,
-0.0014970578,
0.008153486,
0.0021388894,
0.006789079,
-0.001733522,
0.019984938,
-0.022054618,
-0.0029924677,
-0.01432957,
-0.012483995,
0.015173262,
0.03308852,
-0.034485884,
0.012411491,
0.011798496,
0.00013429852,
0.028184565,
0.012912433,
0.0042019784,
-0.0083314525,
-0.0052961404,
-0.027024489,
0.020854995,
-0.0030171853,
0.016320154,
0.014632772,
-0.0028886541,
0.048459522,
-0.016412433,
-0.016807914,
0.010559324,
-0.012734466,
0.01915443,
-0.0010710926,
-0.007916198,
0.012839927,
0.021224111,
0.027920911,
0.0073229773,
-0.0034571572,
0.00012142482,
0.009491527,
0.001703861,
0.03324671,
0.022067802,
0.024348404,
0.0145404935,
0.018930325,
0.008562149,
-0.011996237,
0.015502828,
0.013024485,
0.011580982,
-0.026998123,
-0.0032544734,
0.005184088,
0.034485884,
0.0045875716,
0.01078343,
-0.009069682,
-0.022028254,
0.022001889,
-0.016649721,
-0.010605464,
-0.6445802,
-0.03140114,
0.019338988,
-0.00030155375,
-0.014593224,
0.024269309,
-0.001026601,
-0.017954806,
-0.0022674205,
0.046113007,
-0.003967986,
-0.0021125241,
0.019787198,
-0.0050819223,
-0.0047062156,
-0.033114884,
-0.008799437,
0.007889832,
0.02043315,
-0.016227875,
-0.008944446,
-0.018943507,
-0.021870062,
0.011337102,
0.0043502836,
0.017453864,
0.016214693,
-0.021593226,
-0.011989645,
0.029133717,
-0.0035758012,
0.007573448,
0.014013186,
-0.005549907,
0.060798507,
-0.010869117,
-0.008601697,
0.048670445,
0.025574394,
0.014672319,
-0.01447458,
-0.00974859,
0.019800382,
-0.019286256,
-0.023333339,
0.030451985,
-0.006232111,
0.0041657262,
0.014738233,
-0.009313562,
0.0021850287,
0.014672319,
0.00792938,
0.023096051,
0.03314125,
0.001604167,
0.01314313,
0.006657252,
-0.0030748595,
0.004607346,
-0.01881168,
0.01812618,
-0.006518834,
-0.033299442,
0.005991527,
0.022581926,
-0.015964223,
-0.020274958,
0.01181827,
-0.0036252362,
0.02068362,
0.02525801,
-0.009056499,
-0.0023250948,
-0.008324861,
0.03047835,
0.0040701516,
0.020802265,
-0.02314878,
0.012431265,
0.008608288,
-0.005025896,
-0.039627127,
0.017427498,
0.006627591,
0.0047688335,
-0.025047086,
0.00546422,
-0.010895483,
-0.024111116,
0.0057212817,
0.022489648,
-0.035329577,
-0.034354057,
-0.006815444,
0.027261777,
-0.014632772,
0.019919025,
0.026273075,
-0.018666672,
-0.017322037,
-0.00012719224,
0.01038795,
0.012022601,
0.024506597,
-0.005411489,
-0.031032022,
-0.014975522,
0.01949718,
-0.024453867,
0.020011304,
0.0070593236,
-0.013439739,
0.0062881373,
0.011890775,
-0.014566858,
0.021883244,
0.027736353,
-0.014790964,
-0.0308211,
0.01683428,
-0.0012218694,
0.013334278,
-0.023267426,
0.0069406796,
0.012958572,
0.010078156,
0.009511301,
-0.014145013,
-0.01688701,
-0.021606408,
-0.0065814517,
0.008773072,
-0.015133713,
-0.007692092,
0.02604897,
0.03514502,
-0.007046141,
0.0006649013,
-0.048274964,
-0.04057628,
-0.021685503,
0.007296612,
-0.03229756,
0.004613937,
0.009728815,
-0.010598873,
0.00408663,
0.016096048,
-0.0005940444,
0.015977405,
-0.008713749,
-0.009227874,
-0.009768364,
0.011264598,
-0.0027667144,
-0.01693974,
-0.02068362,
-0.0029463284,
-0.006739644,
-0.015199627,
0.010776838,
-0.0007452332,
0.0028573454,
-0.034538615,
-0.005414785,
0.0030830987,
-0.00011215574,
0.028000006,
-0.038862534,
0.00036643722,
-0.009274013,
-0.018798498,
0.0004754003,
0.0191017,
0.00640019,
-0.047167618,
0.002272364,
-0.002410782,
-0.012286255,
0.013894542,
-0.024401136,
-0.0037109237,
0.0038921854,
0.022832397,
0.030979292,
0.028184565,
0.013037668,
0.0013668789,
0.037333343,
-0.006686913,
0.009227874,
-0.0060343705,
0.035883248,
0.0070197755,
-0.035962343,
0.0070131845,
-0.008997178,
0.016952923,
0.019128066,
0.0018587575,
-0.01802072,
0.015740117,
-0.028052738,
-0.0026645486,
-0.0041657262,
-0.0003779721,
-0.011027309,
0.022634657,
0.0059256135,
0.012668553,
0.01566102,
-0.01427684,
-0.008786255,
-0.004880886,
0.005592751,
0.005230227,
0.017493412,
0.0077975537,
-0.03229756,
-0.008812619,
-0.00964972,
0.02239737,
-0.024387954,
-0.016807914,
0.011653487,
0.006907723,
-0.008924672,
-0.0023992474,
-0.000096295335,
-0.0035428444,
-0.017203394,
0.01861394,
0.007968929,
0.015766483,
0.01900942,
-0.01693974,
-0.010209983,
0.01945763,
-0.0027980232,
-0.008720341,
0.005381828,
0.007784371,
0.009807912,
0.0015267188,
-0.011983054,
0.03604144,
0.014685502,
-0.008496235,
0.013802263,
-0.013578158,
-0.0076129963,
-0.023649722,
0.006100284,
0.006291433,
0.012991528,
0.015924674,
0.0028935976,
0.040602647,
0.012404899,
0.02068362,
0.01585876,
-0.004264596,
-0.016755182,
0.0021240588,
0.013472696,
0.009616763,
-0.0145404935,
-0.00851601,
0.0010348401,
-0.029819217,
0.0033072042,
-0.00699341,
-0.010552733,
0.016399251,
0.0014435032,
0.014632772,
0.0058267433,
0.030372888,
0.0067824875,
0.002882063,
-0.0101704355,
0.025244826,
0.014962339,
-0.012694919,
-0.022647839,
-0.035382304,
0.006291433,
0.003417609,
0.00041134073,
0.03235029,
0.023109233,
-0.0015176557,
-0.0026035788,
-0.005437854,
0.00037735412,
0.018732585,
-0.04703579,
0.025679855,
0.0059486832,
0.0009746942,
-0.007705275,
-0.020723168,
-0.016742,
0.039811686,
-0.005770717,
-0.001784605,
-0.007922789,
-0.03327308,
-0.018548027,
0.0039416207,
-0.008983995,
0.011185502,
-0.0073691164,
0.0018900663,
-0.0012943741,
0.00045233063,
-0.0021553678,
0.031532966,
-0.025732586,
-0.015542377,
-0.04258005,
0.009287196,
-0.023333339,
0.021105466,
0.003816385,
-0.013202451,
0.02974012,
-0.002063089,
-0.0029941157,
-0.00033863002,
-0.021988707,
0.003786724,
-0.017546143,
-0.029318275,
0.006495764,
0.029555563,
0.0056125247,
0.006749531,
0.015331454,
0.024809798,
-0.022766484,
-0.035408672,
0.012543318,
-0.0021850287,
-0.00077077467,
0.011383242,
0.04819587,
0.02865914,
-0.0012927263,
0.008819211,
0.012806971,
-0.018521661,
-0.024928443,
-0.0046831463,
0.027024489,
0.0025343697,
-0.015054617,
0.00020175676,
-0.019114882,
-0.000118232136,
0.018890776,
0.008608288,
0.014790964,
0.005075331,
0.0076261787,
0.0014014834,
0.01024294,
0.005741056,
-0.0019395014,
-0.009735407,
0.021276841,
-0.0026035788,
-0.015595107,
0.036067806,
-0.0028177972,
-0.014092282,
-0.019655371,
-0.0052664797,
-0.010249532,
-0.009438797,
0.0015415493,
-0.013894542,
-0.018178912,
-0.02210735,
-0.005052261,
0.023860646,
-0.015397367,
-0.032983057,
-0.017691152,
0.0050687394,
0.005750943,
-0.03535594,
-0.0027634187,
0.0054477416,
-0.03909982,
-0.03519775,
0.008733524,
0.043977413,
0.01890396,
0.025205279,
-0.008700567,
0.010546142,
0.011310738,
-0.022555562,
-0.014171378,
0.015173262,
-0.045137487,
0.023386069,
0.017651604,
-0.0046304152,
-0.013017894,
-0.015529194,
0.0035955752,
0.013149721,
0.0010587338,
0.004386536,
0.012905841,
-0.002074624,
0.009781547,
0.009623354,
0.012352169,
-0.006617704,
-0.019563094,
-0.019919025,
-0.020736352,
-0.01398682,
-0.0070329583,
-0.029608293,
-0.019259892,
0.0072306986,
-0.011238232,
-0.008891716,
-0.0121280635,
0.03200754,
-0.028896429,
0.010822978,
-0.009834277,
-0.0040503778,
0.007823919,
0.005731169,
0.03253485,
0.016030136,
0.00063235656,
-0.011706217,
-0.016702453,
0.008825802,
0.011745766,
-0.0055400203,
0.013551792,
-0.019629007,
-0.032403022,
-0.018745767,
-0.012200568,
0.010256123,
0.012121472,
0.0015456689,
-0.03717515,
-0.022779666,
-0.020459516,
-0.0033170911,
0.018693037,
-0.0021191153,
-0.010974579,
-0.0073097944,
-0.015502828,
-0.0019905842,
0.0020054148,
0.04234276,
-0.027156316,
-0.018653488,
0.014355935,
0.00027951394,
0.017625239,
-0.016742,
0.0027090402,
-0.018482113,
-0.0070197755,
-0.021303207,
-0.025693038,
-0.002900189,
-0.014158196,
0.046772137,
0.017532961,
0.029371005,
0.002590396,
0.024071569,
0.022608291,
-0.0015613233,
0.00398776,
-0.0019774016,
0.00640019,
-0.011969871,
-0.013413374,
0.002132298,
-0.0010991057,
-0.015186444,
-0.023715636,
-0.00950471,
-0.005352167,
-0.015621472,
-0.0023959517,
-0.009636537,
-0.024506597,
-0.025640307,
0.019483997,
-0.013670436,
0.0075339,
-0.030768368,
-0.005101696,
0.008357817,
0.0060442574,
0.016676087,
0.0014179617,
0.014764599,
-0.016030136,
0.015753299,
-0.020499064,
0.007026367,
-0.01821846,
-0.009498119,
0.012213751,
-0.0033714697,
0.012576275,
0.01541055,
-0.008087573,
0.0041393605,
0.004765538,
0.007955746,
-0.0026035788,
-0.00783051,
-0.028500948,
-0.01216102,
-0.016570626,
-0.0059750485,
0.0063112066,
0.009985878,
-0.023135599,
-0.009181735,
-0.0020499064,
-0.022779666,
0.0029314978,
-0.034485884,
-0.0012795436,
0.04308099,
0.013340869,
-0.0028375713,
-0.027499065,
0.026101701,
-0.0021982114,
0.0043832404,
-0.030214697,
-0.0017252829,
0.0012894307,
-0.009445388,
0.043766487,
0.010480229,
-0.027762718,
-0.009741998,
0.0067231655,
-0.008258947,
0.012345578,
-0.025442567,
0.02757816,
0.00021669026,
0.024427501,
-0.03195481,
-0.0087928455,
-0.022871945,
0.02491526,
-0.015291906,
-0.0009952921,
0.0058432217,
0.011403016,
-0.015871944,
0.0016016953,
0.013696802,
0.020446332,
0.009570624,
-0.0051049916,
-0.0074218474,
-0.025679855,
-0.008252356,
0.008179851,
-0.004215161,
0.0150018865,
0.018033903,
0.017994355,
0.02392656,
0.011370059,
0.005424672,
-0.0026661966,
-0.008232582,
0.036067806,
-0.015516011,
-0.010374767,
0.0052862535,
0.005006122,
0.014764599,
0.0022806032,
-0.010335219,
-0.015845578,
-0.02032769,
0.011284372,
0.034195866,
0.008239173,
-0.015845578,
0.009320153,
-0.024902077,
-0.011587573,
-0.019734468,
0.00092361134,
-0.00576083,
-0.011613939,
0.0005874531,
0.0105131855,
0.011488703,
0.0150018865,
0.0023432209,
-0.0021751418,
-0.020499064,
0.012055558,
-0.033905845,
0.013387009,
0.0094849365,
0.0031078162,
-0.0051906793,
0.0056388904,
-0.015819212,
-0.026338989,
0.008384183,
-0.016531078,
-0.024743885,
0.0032264602,
-0.017822979,
-0.0029957634,
0.030900195,
-0.0006092869,
0.011330511,
0.01038795,
0.01679473,
-0.015291906,
0.0035428444,
0.020815447,
-0.014026369,
0.0027683622,
0.03746517,
-0.018627124,
0.005968457,
0.037755188,
0.0016206454,
0.023544261,
0.003618645,
-0.0227533,
-0.0117853135,
0.0059651616,
-0.026760835,
-0.0008799437,
0.0023465166,
0.0020301323,
-0.0137363495,
0.0022954338,
0.015871944,
-0.008054616,
-0.028237294,
-0.0009952921,
0.005062148,
-0.011389833,
-0.007065915,
0.0154632805,
0.013182677,
-0.0034307917,
-0.015015069,
-0.01147552,
-0.015291906,
0.035039555,
0.006040962,
-0.002580509,
-0.010249532,
-0.0016214693,
-0.022819214,
-0.014461397,
0.00074894086,
0.009175143,
-0.018824862,
0.0048644077,
0.0053587584,
-0.013828629,
-0.021790966,
0.010658194,
0.0064628078,
-0.035883248,
-0.009129004,
0.013176086,
0.0072702467,
0.005421376,
-0.019800382,
-0.0043700575,
0.034749538,
0.0009334983,
-0.011561208,
0.027340872,
-0.01289925,
0.00078807696,
-0.014685502,
0.00068797095,
0.014527311,
0.024045203,
0.023372887,
-0.019998122,
-0.016623355,
0.014487762,
0.005727873,
0.0041393605,
-0.0014583337,
0.0008300967,
0.01595104,
0.007197742,
-0.0010134183,
-0.016755182,
0.013103581,
-0.014065917,
0.029344639,
0.020222226,
-0.014421849,
0.0050094174,
-0.002292138,
-0.014685502,
-0.026180796,
-0.004234935,
-0.013960456,
0.0060244836,
0.005134653,
0.0024091343,
-0.026167614,
0.0061793798,
0.017849345,
-0.021553677,
0.006887949,
-0.009386066,
-0.0017516483,
-0.028079102,
0.0065814517,
0.008034842,
-0.013564975,
0.0054081935,
0.007283429,
-0.01836347,
-0.02181733,
0.002730462,
-0.014039551,
-0.0133936005,
0.0101704355,
0.0032544734,
0.0031720817,
0.0018900663,
-0.020551793,
-0.012602639,
-0.020854995,
0.018337104,
0.19468178,
-0.020604525,
0.0059651616,
0.01895669,
-0.006426555,
-0.0024865826,
-0.010097931,
-0.023992473,
-0.006653956,
-0.0035494359,
0.030504715,
0.0028870064,
0.008628062,
-0.00006637684,
0.006050849,
-0.009735407,
-0.007573448,
-0.003677967,
-0.026774017,
-0.009425614,
0.009036725,
0.0056652557,
-0.0043338053,
-0.010935031,
0.04170999,
0.01152166,
-0.022054618,
-0.010269306,
0.01663654,
0.008529192,
-0.012411491,
0.010961397,
-0.0026579574,
0.03364219,
0.03179662,
-0.0018389835,
-0.014975522,
0.006439738,
0.02979285,
-0.0036713756,
0.0015983996,
0.0116732605,
-0.008924672,
0.01398682,
-0.00032029787,
0.009544258,
-0.0026942096,
-0.009992469,
-0.024743885,
0.004234935,
-0.03190208,
-0.0036153493,
0.0007542963,
0.018310739,
0.008483053,
0.0068220356,
0.017994355,
0.018231643,
-0.013670436,
0.011205276,
-0.017427498,
-0.005332393,
-0.025785318,
0.0137363495,
-0.028210929,
0.057001896,
-0.03366856,
-0.013479288,
-0.023412434,
-0.011363468,
0.0056982124,
0.0040932214,
0.0022278724,
-0.016399251,
-0.011660078,
0.008595105,
0.017453864,
-0.0072175157,
0.015687386,
0.007454804,
0.0069538625,
0.0077711884,
-0.0421582,
0.014817329,
-0.008937855,
-0.028870063,
0.010790021,
0.0037537673,
-0.026866296,
0.0026068743,
0.0121280635,
-0.018508479,
-0.0066045215,
-0.00846987,
0.010546142,
-0.019431267,
0.008555558,
0.001995528,
-0.026694922,
-0.0069538625,
-0.03928438,
0.07767233,
-0.0001464513,
-0.004722694,
-0.005332393,
0.013828629,
0.004116291,
0.02136912,
0.0012177498,
0.0054048975,
0.011910549,
-0.015937857,
-0.0020878066,
-0.017467048,
-0.0026134658,
0.017546143,
-0.02741997,
-0.0015679147,
0.024348404,
-0.009979287,
0.001954332,
-0.015160079,
0.010236349,
0.02408475,
-0.014118647,
0.009979287,
-0.038467053,
0.02142185,
-0.005530133,
-0.025376653,
0.000084606014,
-0.002430556,
0.0070395498,
0.028764602,
0.020894544,
-0.0018290965,
0.0006327685,
-0.0072504724,
-0.005273071,
0.0015572037,
-0.016952923,
-0.011152545,
0.016465165,
0.01191714,
-0.0038658201,
-0.015331454,
0.022252358,
0.019312622,
0.0012572978,
-0.013103581,
-0.007652544,
-0.025126183,
-0.00039218465,
-0.0104077235,
0.008463278,
-0.039627127,
-0.021527313,
-0.029977407,
0.0032132776,
0.0108823,
-0.014949156,
0.008773072,
0.0065023554,
-0.029476466,
-0.013380418,
-0.008608288,
-0.16557443,
0.011528252,
0.047536734,
-0.02142185,
0.027630892,
0.00827213,
-0.008357817,
0.020274958,
-0.0029150194,
-0.0094849365,
0.044109236,
-0.006390303,
-0.03801884,
-0.020894544,
-0.00087664806,
0.004422788,
0.015252357,
0.04279097,
0.022858763,
0.019128066,
0.03179662,
-0.01870622,
0.016030136,
-0.017625239,
0.01024294,
0.0068615833,
0.0027354055,
0.021105466,
0.004722694,
-0.031664792,
-0.013156312,
0.00356921,
0.011455746,
0.007962337,
0.019325806,
0.007744823,
0.009214692,
0.00061670213,
0.0010447272,
0.017809797,
0.05051602,
0.008806028,
0.0014583337,
-0.0026085223,
-0.027894545,
0.023399252,
0.010163845,
0.006578156,
0.0067824875,
-0.011093223,
-0.0019806973,
-0.023887012,
0.00299082,
0.0023086164,
0.012622413,
0.01767797,
-0.006060736,
0.017519778,
-0.0013915964,
-0.01625424,
-0.014830512,
-0.03625236,
0.022911493,
0.00046386546,
-0.01983993,
-0.010842752,
0.0029743416,
0.01832392,
-0.024743885,
0.00016468047,
-0.021527313,
-0.006808853,
0.0011378299,
0.0001583981,
0.025838047,
0.0024322039,
-0.01600377,
-0.0034571572,
-0.009517893,
0.033299442,
0.008509418,
0.012846519,
-0.01152166,
0.008377591,
-0.008726932,
0.0055037676,
0.017598875,
0.014250474,
0.0027815448,
-0.0020070625,
0.016372886,
-0.025732586,
0.01038795,
-0.012688327,
0.02491526,
0.018930325,
-0.00047004485,
0.0044326754,
-0.023913376,
0.008476461,
-0.005072035,
-0.013525427,
-0.019391717,
0.03480227,
0.0010471989,
-0.01526554,
-0.016768366,
-0.025218463,
0.047774024,
-0.0070395498,
-0.002254238,
-0.00028363353,
0.0063968943,
0.046613947,
-0.037755188,
0.020894544,
0.019879477,
-0.018495297,
0.011943506,
-0.039258014,
0.06290773,
0.007764597,
-0.013182677,
0.013894542,
-0.0030105938,
-0.049514137,
-0.14058007,
-0.016504712,
-0.013630888,
-0.009821095,
-0.0035032965,
0.01964219,
-0.0017944919,
0.00906309,
-0.011640304,
0.013472696,
-0.02003767,
0.0047820164,
-0.012068741,
-0.008628062,
0.0035856883,
-0.0041822046,
0.008740115,
-0.018231643,
0.0015168318,
0.026892662,
-0.0071516023,
-0.01836347,
0.015529194,
0.017822979,
0.020604525,
0.0014336162,
-0.026404902,
0.018205278,
-0.004772129,
0.012905841,
0.03245575,
-0.0071713766,
0.009610171,
-0.013604523,
-0.013136538,
-0.006538608,
-0.0032824867,
-0.020116765,
0.015911492,
-0.0023399252,
-0.0051049916,
0.014711868,
0.00045191866,
0.0035230706,
-0.0004006298,
0.00472599,
-0.004073447,
0.003298965,
0.0033187391,
-0.022766484,
-0.014580041,
-0.020709986,
-0.052994363,
-0.013815446,
0.015094166,
-0.003079803,
0.013485879,
0.037016958,
-0.029502831,
0.00649906,
0.008285313,
0.009175143,
-0.02752543,
0.014290022,
0.010269306,
-0.035645958,
-0.009465163,
-0.03762336,
0.020024488,
-0.02408475,
0.01295198,
-0.010908665,
-0.0044293795,
0.006571565,
-0.013347461,
-0.001356168,
-0.0137363495,
-0.010328628,
0.009827686,
-0.00822599,
-0.013017894,
-0.013373826,
0.020670438,
-0.012365351,
0.02979285,
0.019602641,
-0.0051082876,
0.013017894,
-0.005655369,
-0.0129256155,
-0.02239737,
0.031743888,
0.010447272,
0.008351226,
0.0040503778,
0.0075998134,
-0.0023283905,
-0.023030138,
0.00065830996,
0.001703861,
-0.022252358,
-0.013189268,
-0.041894548,
0.019141247,
-0.027209045,
-0.0037043323,
0.001275424,
-0.018600758,
-0.0060838056,
-0.022964224,
0.0027996711,
0.040312625,
-0.016623355,
0.012371942,
-0.0074613956,
0.012760832,
-0.015845578,
-0.038862534,
0.015502828,
-0.004722694,
0.008179851,
-0.007863467,
-0.0070131845,
-0.0062551806,
0.015529194,
0.0150678,
-0.002750236,
0.004373353,
-0.012042375,
0.027604526,
-0.00777778,
-0.033932213,
0.011258006,
-0.0408663,
-0.014184561,
0.0060541444,
-0.019932209,
-0.029476466,
-0.0071779676,
0.019853111,
-0.009643128,
0.005193975,
-0.017941624,
-0.044293795,
0.01068456,
-0.0026332398,
0.004584276,
-0.00070774497,
-0.020947274,
0.008232582,
-0.00910923,
-0.00267114,
0.0415518,
0.016333338,
-0.024137482,
-0.049461406,
-0.017111115,
0.017585691,
-0.0032528257,
-0.007487761,
-0.018824862,
-0.014461397,
0.017150663,
0.0341695,
0.009069682,
0.017532961,
0.0030369593,
-0.009148778,
0.001525071,
0.008410548,
-0.0016330042,
-0.016280606,
-0.033404905,
-0.00027724818,
0.00777778,
-0.017216576,
0.019444449,
-0.016425615,
-0.0011411255,
-0.0082193995,
-0.014527311,
0.045664795,
0.0070395498,
-0.000548317,
0.0065056514,
0.0075075347,
0.032165732,
0.010658194,
-0.014105464,
0.04363466,
0.0017763658,
0.0040009427,
-0.017005654,
0.01585876,
0.024638424,
-0.017071567,
0.015476463,
0.021316389,
0.014580041,
0.02910735,
0.00055243657,
0.039231647,
-0.0014262008,
-0.005451037,
-0.0048874775,
-0.033563096,
0.006716574,
0.004234935,
-0.020841813,
0.011468929,
-0.006337572,
0.016135598,
-0.0066144085,
0.023544261,
0.00024367355,
0.0039943513,
-0.028870063,
0.01378908,
-0.031163849,
-0.011231641,
-0.013004711,
0.018495297,
0.023952926,
0.006429851,
-0.016873827,
-0.022371003,
0.018152546,
-0.0006389479,
0.03575142,
-0.013696802,
0.03427496,
0.003628532,
0.027947275,
-0.0071186456,
-0.045717526,
-0.0104011325,
-0.00008522395,
-0.014237291,
0.019879477,
0.028131833,
-0.002033428,
0.079254255,
0.0051676095,
-0.012642188,
0.00050464936,
-0.02939737,
0.021725053,
-0.0033484001,
0.009702451,
0.0050819223,
-0.051728826,
0.030952927,
-0.001295198,
0.026774017,
-0.02048588,
-0.018745767,
0.0042217523,
-0.017585691,
0.014698685,
0.011053675,
-0.016425615,
0.030610176,
-0.010743882,
-0.007725049,
0.022094168,
-0.034248594,
-0.0114425635,
0.03511865,
-0.009821095,
0.00797552,
-0.05257252,
-0.003040255,
0.011310738,
-0.048064042,
0.0021273545,
0.0021438329,
0.0115480255,
-0.009860642,
-0.008080981,
0.0052269315,
-0.0010653251,
-0.00802825,
0.0031259423,
-0.024730703,
-0.02939737,
-0.009227874,
-0.007949155,
-0.0139736375,
0.0021273545,
-0.020538611
] |
Infection with Helicobacter pylori (H. pylori) is a risk factor for the development of gastric cancer. Here we show that infection of gastric epithelial cells with 'cag' pathogenicity island (cagPAI)-positive H. pylori induced aberrant expression of activation-induced cytidine deaminase (AID), a member of the cytidine-deaminase family that acts as a DNA- and RNA-editing enzyme, via the IκB kinase–dependent nuclear factor-κB activation pathway. H. pylori–mediated upregulation of AID resulted in the | [
-0.019045765,
-0.015016599,
0.027302906,
-0.016448013,
-0.029158443,
0.020901302,
-0.014459937,
0.00024457474,
0.01032474,
-0.019536156,
0.006202796,
0.0059012715,
-0.0029771433,
0.013492407,
-0.013969545,
0.012829715,
0.029556058,
-0.0006167176,
-0.008124603,
0.024546107,
-0.055242,
0.022054385,
-0.00056245975,
-0.0059112115,
-0.0069648917,
0.03570584,
0.008257141,
-0.039469928,
-0.0067329495,
-0.0055732387,
0.0044433493,
0.0022100774,
-0.009522882,
0.014473191,
-0.01165675,
-0.0014347279,
0.02241224,
-0.020609718,
0.01589135,
0.005417506,
0.02634863,
-0.00866801,
-0.015334691,
0.0022879438,
-0.015427467,
0.004781322,
0.016394997,
-0.018807195,
-0.015175644,
0.026202837,
0.017892681,
-0.014592475,
0.00057695614,
0.006252498,
-0.011848931,
-0.0009642167,
0.0047912626,
0.028760828,
-0.0021852264,
0.003359848,
-0.001882045,
0.008833683,
-0.016421504,
0.012094127,
-0.007051042,
0.031279057,
0.012697177,
-0.00082256633,
0.018064981,
0.011100089,
0.054208197,
0.035838377,
-0.010702474,
-0.0069980263,
0.0012375771,
-0.013134553,
-0.03276349,
-0.0088005485,
-0.0047780084,
0.022677317,
0.030192243,
-0.021126617,
0.018210772,
0.026123315,
0.023671355,
-0.008787295,
-0.014592475,
0.022332717,
0.0106494585,
-0.022253193,
0.030854935,
0.03180921,
0.017945696,
0.036421545,
-0.0068389806,
0.022041133,
0.0019102094,
0.034274425,
0.015626274,
-0.035069656,
-0.008349918,
-0.0061630346,
-0.0016219384,
-0.008343291,
-0.019032512,
0.010768743,
-0.007965556,
-0.027355922,
0.015719052,
0.009840975,
-0.026865529,
0.030324781,
0.0011530839,
-0.03021875,
0.017044436,
-0.015944367,
0.01671309,
0.020384403,
-0.025367845,
-0.013943038,
0.0043737665,
0.025129277,
-0.00324222,
-0.007760122,
0.025155785,
0.009556017,
-0.008535472,
-0.000039554423,
0.009794586,
-0.0107753705,
0.017693873,
0.024161747,
0.027780045,
0.026202837,
-0.019536156,
0.008721026,
-0.0243473,
-0.031279057,
-0.020914556,
-0.04037119,
0.0007277185,
0.031650163,
-0.00858186,
-0.0047051124,
-0.0002824724,
0.0043240646,
0.01269055,
0.009436732,
0.003982778,
0.013638199,
0.0143273985,
-0.01740229,
-0.013717722,
-0.016249206,
0.004320751,
0.013074911,
-0.014632237,
0.009741571,
-0.011325404,
-0.03525521,
-0.009986767,
-0.011000685,
0.009509629,
-0.0075546876,
0.0049668755,
0.030960966,
0.0070112804,
0.025632922,
-0.015798574,
-0.025434114,
-0.008595114,
0.0074817915,
-0.015719052,
0.011365166,
0.0053379834,
0.012895985,
-0.01198147,
0.03305507,
-0.00079274515,
-0.023684608,
-0.021113364,
0.014300891,
0.027647506,
-0.007892661,
0.007780003,
-0.01522866,
0.0011762781,
-0.006706442,
-0.025063008,
-0.03276349,
-0.0016666701,
0.014552714,
0.002826381,
-0.0036216113,
-0.6383048,
-0.040874835,
-0.005026518,
-0.007044415,
0.018330058,
0.021484472,
0.01630222,
-0.004804516,
-0.010801878,
0.005377745,
-0.026335375,
0.02168328,
0.013121299,
-0.0062425574,
-0.0074088955,
-0.018661404,
0.0077336146,
-0.023697862,
0.008992729,
0.014353907,
-0.015361198,
-0.014353907,
-0.007839645,
0.009827721,
-0.0023691235,
0.02862829,
0.027912583,
-0.017375782,
0.014923821,
0.03183572,
-0.015135883,
0.00064488203,
-0.028760828,
-0.030642873,
0.052034568,
-0.0038568669,
0.007965556,
0.018078234,
0.010735609,
0.02838972,
0.00393639,
-0.020384403,
0.005841629,
0.0050165774,
-0.0048707854,
0.0004953622,
0.016514283,
0.020145833,
0.009330702,
-0.010583189,
-0.0021504352,
0.015162391,
-0.019496396,
-0.0015896321,
0.029847642,
0.0030351288,
0.024546107,
-0.029290982,
0.015666036,
0.008190872,
0.007607703,
0.04424131,
-0.020132579,
-0.012107381,
-0.0037740304,
-0.005891331,
-0.009410225,
0.007998691,
0.0014943702,
0.012127262,
0.019138541,
0.014261129,
-0.01699142,
0.0023210784,
0.02000004,
0.05874101,
-0.013180942,
0.021590501,
-0.016978167,
0.0035884767,
0.016076906,
0.0061133327,
-0.021882087,
0.031093504,
0.016209444,
0.006865488,
-0.027461952,
0.019496396,
-0.00026942568,
-0.018250534,
0.020278372,
0.0011365166,
-0.02320747,
-0.017654112,
-0.030828428,
0.008310156,
-0.027117353,
-0.013863514,
0.008833683,
-0.019310841,
-0.012286307,
-0.014738268,
0.0100265285,
0.0027253204,
0.027011322,
0.00033673033,
-0.024320792,
-0.014049068,
0.03170318,
-0.025911253,
0.00806496,
-0.007813137,
-0.0065805307,
-0.0028147837,
-0.008641502,
-0.023538817,
0.034486488,
0.016633566,
-0.013419511,
-0.018422835,
0.0065010074,
-0.011000685,
-0.006391663,
-0.021166379,
0.014075576,
0.019655442,
0.0026457973,
-0.033929825,
0.0008213238,
-0.0020112698,
0.01761435,
-0.003015248,
0.007017907,
-0.009642167,
0.019430127,
0.008899952,
0.012597773,
0.007514926,
0.009728317,
-0.021868832,
-0.04082182,
-0.011477823,
0.019006003,
0.009642167,
-0.006640173,
-0.00144384,
-0.027196875,
0.0040125996,
0.012372457,
0.018701166,
0.023777384,
0.008641502,
-0.012372457,
0.029105429,
0.01165675,
-0.014778029,
-0.0011042104,
-0.0066567403,
0.0015821769,
-0.016037144,
0.0057886136,
0.03878073,
0.0058350023,
-0.005119295,
-0.022889378,
0.009708436,
0.013717722,
0.0014546087,
-0.00024395346,
-0.024360554,
0.016580552,
-0.0143273985,
-0.0029274414,
-0.0027982164,
0.0138105,
-0.0066799344,
-0.01068922,
0.010563308,
-0.012617653,
-0.008827056,
0.0025033187,
-0.009191536,
0.0031113385,
-0.0000073776246,
0.01488406,
0.01540096,
-0.0022531524,
0.0137044685,
0.023154454,
0.03716376,
-0.021047095,
0.013611692,
-0.017442051,
0.027276399,
-0.007534807,
-0.026441406,
0.020092819,
0.025712445,
-0.009522882,
0.0317827,
0.0022879438,
-0.017070943,
0.020251865,
-0.009754824,
0.015361198,
-0.0073956414,
0.00062168785,
-0.0138502605,
0.028204167,
-0.0064513055,
0.002972173,
0.0009774705,
-0.009416852,
-0.001584662,
-0.0026226032,
-0.001339466,
-0.007276357,
0.0064247977,
-0.012299562,
-0.0037740304,
-0.01927108,
0.015732305,
0.012286307,
-0.0065440824,
-0.0055069695,
0.012193531,
-0.011139851,
0.008436068,
0.0017660739,
-0.025063008,
0.0045195585,
0.01834331,
-0.011928454,
0.010404263,
0.025235306,
0.027912583,
0.0030467259,
0.0053843716,
0.03512267,
0.005371118,
-0.010053036,
-0.0036381786,
-0.025288323,
0.0035023268,
-0.0051756236,
0.013472526,
0.04082182,
-0.00018027291,
-0.03271047,
0.04827048,
0.0036116708,
0.0060768845,
-0.016805867,
-0.0013162717,
-0.0015233629,
-0.024307538,
0.016527535,
0.018051727,
0.04254482,
0.014314145,
0.014420176,
-0.012266427,
-0.001814119,
-0.020265117,
-0.01120612,
0.00019787566,
0.010212082,
-0.00787278,
-0.016660074,
0.014393668,
-0.019112034,
-0.017680619,
0.012392338,
-0.03294904,
-0.00024954492,
0.019748218,
-0.01681912,
0.0063088266,
0.006805846,
-0.0032471903,
-0.018608388,
-0.037004717,
0.039072312,
0.00980784,
-0.0073823878,
-0.017972205,
-0.026534183,
0.0043671397,
-0.0042511686,
0.021391694,
0.009688555,
0.02286287,
0.004688545,
0.013717722,
-0.0024850946,
-0.016421504,
0.026322123,
-0.005304849,
0.023300247,
0.018383073,
-0.024890708,
-0.011232628,
-0.015732305,
-0.0004411043,
0.028522259,
0.022783346,
0.00074884185,
-0.003807165,
-0.00057654193,
-0.022319462,
-0.011047074,
0.017985458,
-0.0064148577,
0.0021106736,
-0.015785322,
-0.007123938,
-0.018290296,
-0.00095427636,
0.016315475,
0.003396296,
-0.022213433,
-0.02697156,
-0.0004460745,
0.004781322,
0.027276399,
0.013121299,
-0.013783991,
0.012140515,
0.019363858,
0.006110019,
0.0017627605,
-0.0486946,
0.013260465,
-0.015268422,
-0.009058998,
0.020463925,
0.006805846,
-0.0030881441,
0.016554043,
0.025924508,
0.0004052775,
-0.026600452,
-0.019801233,
0.0068323533,
-0.008681264,
0.0036315515,
0.021113364,
0.019880757,
0.009840975,
-0.022253193,
0.02230621,
0.015255167,
0.007707107,
-0.026998067,
-0.007839645,
0.019125288,
0.0017312826,
-0.0060172426,
-0.0050596525,
-0.03191524,
0.01778665,
0.00077493535,
-0.012200158,
-0.0016906927,
0.022465255,
-0.0034725056,
0.010218709,
0.008137857,
0.0052750274,
-0.0008084841,
0.00028909935,
0.017044436,
-0.018330058,
-0.021961609,
0.026083553,
-0.011948335,
0.0022465256,
-0.010563308,
0.036342025,
0.008217379,
-0.008959594,
-0.012524877,
0.0011820766,
-0.009337328,
-0.0030251886,
-0.012080873,
0.013717722,
-0.0024436763,
0.007117311,
-0.0077932565,
-0.0049668755,
-0.03249841,
-0.020622972,
-0.007203461,
0.01591786,
-0.049781416,
0.00003549026,
-0.00744203,
0.014499699,
0.015719052,
0.011590481,
-0.015453975,
-0.0021537486,
0.01819752,
0.00039678678,
-0.013677961,
-0.008045079,
-0.05094775,
0.0031212787,
0.0058548828,
0.00009769528,
-0.00901261,
-0.013068284,
0.009357209,
0.011603735,
0.0053611775,
-0.00568921,
-0.0030715768,
-0.01051692,
0.019297589,
0.011404928,
0.00071736396,
-0.011882066,
0.004526186,
-0.025116023,
-0.03671313,
-0.04084833,
-0.0074088955,
0.002132211,
-0.029741613,
0.0044168415,
-0.0027932464,
0.004058988,
-0.02976812,
0.013876769,
-0.0074354033,
-0.0061663482,
0.0024933782,
0.029582566,
0.03353221,
0.006431425,
-0.0029638894,
0.004370453,
0.007289611,
-0.012988761,
0.012524877,
0.018290296,
0.012220038,
-0.010145813,
0.011663377,
-0.006626919,
-0.013419511,
-0.024241269,
-0.033664748,
-0.019748218,
0.034486488,
0.008899952,
-0.009151775,
-0.02092781,
-0.0043803933,
0.014512952,
0.025301576,
-0.007541434,
-0.053572014,
-0.022372479,
-0.009708436,
0.018780688,
-0.0010155754,
0.0072498494,
-0.037826452,
-0.009801213,
0.024943722,
-0.004708426,
-0.011325404,
0.0062359306,
-0.009920497,
-0.0029141875,
-0.0059112115,
-0.015838336,
-0.011199493,
0.009628913,
-0.0013808842,
0.025434114,
0.023061678,
0.036156468,
-0.01716372,
0.024175,
0.041564036,
0.008866818,
0.0001273611,
-0.0055533582,
0.012060992,
-0.017176975,
0.018449342,
0.017349273,
-0.00952951,
-0.00036965782,
-0.028283691,
0.0077667492,
0.0008656413,
-0.0058615096,
-0.0038369861,
-0.002531483,
-0.038727716,
-0.044214804,
0.006060317,
-0.026441406,
0.0066567403,
-0.044320833,
-0.009628913,
0.02023861,
-0.0012284651,
0.012856223,
-0.008482456,
0.008091468,
0.00022717907,
0.041988157,
0.0012798237,
0.0043240646,
-0.0033200865,
-0.017813157,
0.009271059,
0.027329413,
0.015334691,
0.01813125,
0.028601782,
-0.01008617,
-0.029635582,
0.0030632932,
0.01954941,
-0.007839645,
-0.019814488,
-0.017667366,
-0.027196875,
-0.01722999,
-0.034247916,
-0.0047713816,
-0.038860254,
-0.009536136,
0.0018472536,
-0.019019257,
0.018184265,
0.008224007,
-0.022770094,
0.015162391,
0.0057090907,
0.028999398,
-0.035281718,
0.012034485,
0.020145833,
-0.003432744,
-0.026216092,
0.0010611354,
0.0022349283,
-0.0012922492,
0.018290296,
0.023578577,
0.0074022687,
-0.0051689968,
-0.016103413,
0.0065010074,
0.01269055,
-0.020914556,
0.027621,
-0.02023861,
0.018171012,
-0.009165029,
-0.0078065107,
-0.01357193,
0.028283691,
0.013545423,
0.021643518,
-0.012683922,
-0.005142489,
-0.007143819,
-0.0008565293,
-0.009350583,
0.02120614,
0.00429093,
-0.01460573,
-0.01660706,
-0.0366071,
-0.00057654193,
0.00815111,
-0.008137857,
0.0048210835,
-0.003112995,
0.018860212,
-0.016739598,
-0.0073359995,
0.031994764,
0.0013278689,
-0.012717057,
0.033770777,
-0.015493737,
-0.020278372,
0.008071587,
-0.0035752228,
0.016580552,
-0.01198147,
-0.00622599,
0.0024933782,
-0.042173713,
-0.009966886,
0.01374423,
0.0041782726,
-0.0023194216,
0.017839666,
-0.027223384,
0.007919168,
-0.022637555,
-0.013386376,
0.012869476,
-0.026269106,
-0.003899942,
-0.013068284,
-0.0039562704,
0.007455284,
0.023936432,
0.016249206,
-0.020768763,
0.022783346,
-0.025844984,
-0.013585184,
0.011782662,
-0.00020232811,
-0.0010561652,
0.0075546876,
0.0056063733,
-0.011066955,
0.021776056,
-0.009536136,
-0.020092819,
-0.0335057,
-0.012763446,
0.030165736,
0.019840995,
-0.01043077,
0.0070908032,
-0.00045891415,
0.006693188,
0.0018671345,
-0.0034360576,
0.028575275,
-0.016076906,
0.010006648,
0.022332717,
-0.0040921224,
-0.007945675,
-0.012180277,
0.0076209567,
-0.01305503,
-0.01198147,
-0.0338503,
-0.014552714,
0.007110684,
-0.0011746214,
0.0021073602,
0.0126242805,
0.0013535481,
-0.021590501,
0.014658744,
-0.004658724,
-0.00017758072,
-0.019403618,
-0.010801878,
-0.0074155224,
0.01819752,
-0.01060307,
0.0050828466,
0.0135586765,
-0.009933751,
-0.025275068,
-0.004145138,
-0.029688597,
0.02206764,
0.009436732,
-0.019218065,
-0.03196826,
-0.0043803933,
-0.03170318,
0.0048409645,
0.0049304278,
0.019947026,
0.028522259,
0.009304194,
-0.018396327,
-0.0074354033,
-0.008383052,
0.014844298,
-0.011762781,
-0.00770048,
0.0009675302,
0.0013974515,
0.013837007,
-0.006590471,
-0.020768763,
-0.013253838,
0.009947006,
0.004804516,
-0.00929094,
0.017640859,
-0.020715749,
-0.011027193,
-0.0072962376,
-0.006597098,
0.015135883,
0.018913226,
0.019774726,
-0.016858881,
-0.014247876,
0.015069614,
0.006288946,
-0.016355235,
0.007468538,
-0.004436722,
0.0045825145,
0.0076474645,
0.009469867,
-0.029874152,
0.008681264,
-0.027806552,
0.021325424,
0.01836982,
-0.000256586,
0.001968195,
0.0064711864,
-0.014221368,
-0.031650163,
-0.0064479923,
-0.009562644,
-0.015255167,
0.021285664,
-0.011802543,
-0.01847585,
-0.017110705,
-0.0017329393,
-0.023591831,
-0.012564639,
0.0143273985,
-0.018104743,
-0.015546752,
0.010682593,
0.0013535481,
-0.0007828048,
-0.010921163,
0.011060327,
-0.020079564,
-0.017362528,
-0.008515591,
-0.007263103,
-0.017587842,
0.008588487,
0.0001743708,
-0.0029738299,
0.017044436,
0.021577248,
-0.00542082,
-0.026534183,
0.0001484844,
0.20103422,
-0.015135883,
0.005049712,
-0.0068456074,
-0.015255167,
-0.0117429,
0.016872136,
0.007839645,
-0.0028462617,
0.0023177648,
0.031066997,
0.0038734342,
0.0067727114,
0.003982778,
-0.0018952988,
-0.02286287,
-0.03957596,
-0.006481127,
-0.04092785,
-0.018091489,
0.03180921,
-0.016978167,
-0.010702474,
0.014022561,
0.014446683,
-0.006315454,
-0.048853647,
0.011073582,
0.032233335,
-0.008336664,
-0.024506345,
0.0060238694,
-0.0017727008,
0.006441365,
0.0025729013,
0.012034485,
-0.018621642,
-0.004102063,
0.00087392493,
-0.0056063733,
-0.009874109,
0.016222697,
-0.027276399,
-0.0035520287,
-0.03477807,
-0.012213412,
-0.00770048,
-0.0035586555,
0.017296258,
0.0059675407,
-0.028045122,
-0.017283004,
0.015904605,
-0.002819754,
0.002488408,
-0.021815818,
0.01968195,
-0.0012317785,
-0.014870807,
0.028548768,
0.0009244552,
0.02531483,
-0.025579907,
0.0122598,
-0.030722396,
0.03249841,
-0.031173026,
0.00007874644,
0.012902611,
-0.034062363,
0.005046399,
-0.008820429,
-0.02127241,
-0.0030616366,
-0.026401645,
-0.008071587,
0.014552714,
0.025526892,
0.024188254,
0.019257827,
0.014658744,
0.0073227454,
-0.025951015,
0.017057689,
-0.015255167,
-0.032471903,
0.005970854,
0.027104098,
-0.032657456,
-0.0076540913,
0.008933087,
-0.004701799,
-0.0008631562,
0.004933741,
0.012829715,
0.008111348,
-0.010702474,
-0.0055566714,
0.020543449,
0.0023674667,
-0.013479154,
0.0683898,
-0.020463925,
0.009569271,
-0.021431455,
0.0013129583,
-0.0058151213,
0.0019947025,
0.015666036,
-0.008866818,
-0.0024121986,
0.0060536903,
0.008104722,
-0.011338659,
-0.0055931197,
0.025248561,
0.00806496,
-0.015705798,
0.028787335,
-0.030669382,
-0.009867482,
-0.008906579,
-0.013002015,
0.028813845,
-0.018621642,
0.0017859547,
-0.045142572,
-0.0029324116,
-0.002408885,
-0.037137255,
0.00830353,
-0.0059675407,
-0.0014844298,
0.01985425,
-0.0029771433,
0.01591786,
0.016209444,
-0.030483827,
0.00025617183,
0.0052915947,
-0.011809169,
-0.0034592517,
0.028681306,
0.0086746365,
-0.01137842,
-0.014247876,
0.030165736,
-0.0056063733,
-0.009469867,
-0.0012831371,
-0.01296888,
-0.016872136,
-0.008661383,
0.0067793382,
0.029105429,
-0.028919874,
-0.014910568,
-0.015082868,
-0.0030069645,
0.012047739,
-0.019257827,
0.016037144,
0.042014666,
0.0034990131,
-0.01419486,
-0.015480483,
-0.1671044,
0.005821748,
0.0091120135,
-0.034406964,
0.037587885,
0.025778715,
-0.007362507,
-0.009675302,
0.022041133,
0.01847585,
0.041325465,
-0.008224007,
-0.04331354,
-0.014353907,
0.014035814,
0.021603756,
-0.028151153,
0.023671355,
0.024943722,
0.0027186936,
0.02075551,
0.00029303407,
0.01488406,
0.0013759141,
-0.0056660157,
0.0050364584,
-0.005467208,
-0.017070943,
-0.036129963,
0.007495045,
0.0006846436,
0.028098136,
0.028336706,
-0.016951658,
0.027117353,
-0.012319442,
-0.009483121,
-0.020782018,
0.0025861552,
0.015599768,
0.028681306,
0.0047415607,
0.017070943,
-0.0027485145,
-0.020980826,
0.03090795,
0.0063022,
0.0030417559,
0.035361238,
0.0117097655,
0.026653469,
-0.009695183,
0.019324096,
0.022703825,
0.00026238456,
0.0060702576,
0.010265097,
0.011239255,
-0.012995388,
0.0068389806,
0.0063982904,
-0.010894654,
0.02151098,
0.0054804618,
0.0003276183,
-0.035202194,
-0.0111265965,
0.022942394,
-0.013021896,
0.012650788,
-0.003923136,
-0.019721711,
0.005825062,
-0.024797931,
0.025301576,
0.013943038,
-0.003132876,
0.016593805,
-0.013717722,
0.0063220807,
-0.006554023,
-0.0071504456,
-0.025222054,
-0.042147204,
-0.007369134,
-0.007190207,
-0.0015018255,
0.010278352,
-0.027276399,
-0.020636225,
0.027170368,
-0.029317489,
-0.0052452064,
-0.0056196274,
0.006749517,
0.020516941,
-0.00047423888,
-0.0047117393,
-0.012491742,
-0.011895319,
0.0143273985,
-0.014910568,
-0.027329413,
0.026839022,
0.03263095,
0.0040689283,
-0.022637555,
-0.013499034,
0.054711845,
0.0031395028,
-0.01111997,
0.00806496,
0.020318134,
0.021948356,
-0.023300247,
0.032524917,
-0.03101398,
-0.013247211,
-0.014698506,
-0.031199535,
0.053121384,
0.007031161,
-0.002438706,
0.01843609,
-0.013651453,
-0.022783346,
-0.13137203,
-0.0022150476,
0.017137213,
-0.006785965,
-0.023512308,
0.005357864,
0.009542763,
0.0004763098,
-0.035626315,
0.004449976,
-0.013823753,
-0.0030185615,
-0.022955647,
-0.03090795,
0.020463925,
0.006086825,
-0.00577536,
-0.0026391705,
-0.014115337,
0.016832374,
-0.012829715,
0.001525848,
0.01103382,
-0.009390344,
0.0065672765,
-0.010311486,
-0.023114692,
0.029609075,
0.014870807,
0.012730312,
0.017813157,
-0.005984108,
0.014234622,
0.010881401,
-0.03875422,
-0.012153769,
0.012809834,
-0.011961589,
0.026057046,
-0.00622599,
0.00516237,
0.005583179,
0.0066666803,
0.005944346,
0.02793909,
-0.020291626,
-0.0048509045,
0.012889357,
0.010092798,
-0.023605086,
-0.026560692,
-0.03239238,
-0.015043106,
-0.008402933,
0.005450641,
-0.032021273,
0.018767435,
0.028257182,
-0.004340632,
-0.012962254,
0.0028943068,
0.004973503,
-0.0109410435,
-0.008290276,
0.036554083,
-0.004499678,
0.0020377776,
-0.017375782,
0.021285664,
-0.030271767,
-0.0037773438,
0.011848931,
-0.010795251,
0.0044897376,
-0.007919168,
0.004579201,
-0.0137044685,
-0.007017907,
0.012743565,
0.0018538806,
-0.018873464,
-0.017375782,
0.013127927,
-0.018290296,
0.04561971,
0.0039927186,
0.014565968,
-0.007952303,
0.014870807,
-0.003793911,
-0.015520244,
0.045540188,
0.010331366,
-0.007879406,
-0.021908594,
0.015732305,
0.0027485145,
-0.022292955,
0.0032041152,
0.01374423,
-0.018051727,
-0.002029494,
-0.06277017,
0.001400765,
-0.01245198,
0.010835012,
0.008502337,
-0.018555373,
0.011471197,
-0.012962254,
-0.014353907,
0.035387747,
-0.014300891,
0.019244572,
-0.016527535,
-0.015281675,
-0.013903276,
-0.014420176,
0.028257182,
0.010497039,
0.00096670183,
0.021312172,
-0.006179602,
0.023605086,
0.0007036959,
0.012458608,
-0.020742256,
0.02490396,
-0.019085526,
0.039496437,
0.0111067165,
-0.009602405,
0.017534828,
-0.033161104,
-0.0042379145,
-0.006713069,
-0.020530194,
-0.0095891515,
-0.008873444,
0.022677317,
0.024493093,
0.03992056,
-0.011988096,
-0.026229344,
0.0069118766,
0.0025878118,
0.018316804,
0.013757484,
-0.02030488,
0.02406897,
0.010185574,
-0.00059020997,
0.039310884,
0.00054340734,
0.0046786047,
-0.023843654,
-0.001689036,
-0.01630222,
0.008429441,
-0.021192886,
-0.028469244,
-0.014128591,
0.024479838,
-0.0025281697,
0.022664063,
0.021497725,
0.0053678043,
-0.0074088955,
-0.035202194,
-0.03101398,
0.009801213,
-0.017826412,
-0.025858238,
-0.0045162453,
-0.0131014185,
-0.0012334352,
0.02292914,
0.004910547,
-0.016766105,
0.005119295,
0.0004106619,
-0.005825062,
0.01460573,
-0.008091468,
-0.0025298262,
0.012471861,
0.028893366,
0.0014562655,
0.00044897376,
-0.022637555,
0.004536126,
0.004493051,
-0.007899287,
0.020994078,
0.02355207,
0.024413569,
-0.00065399404,
0.010987432,
0.005467208,
-0.026573945,
0.008542098,
0.033320148,
0.0055997465,
-0.00015728577,
-0.01985425,
-0.006766084,
-0.019072272,
0.017084196,
-0.03342618,
-0.033320148,
-0.007680599,
0.0019665381,
0.0132273305,
0.009052372,
0.007833018,
0.015798574,
-0.0051988177,
-0.006332021,
-0.0003725571,
-0.006540769,
-0.017269751,
0.027170368,
-0.0038270457,
0.024479838,
0.002881053,
-0.014976837,
0.028946383,
0.0035387748,
0.039522946,
-0.016050398,
0.026401645,
-0.034274425,
0.016487774,
-0.0101922015,
-0.031040488,
-0.016593805,
-0.008078214,
-0.011232628,
0.025434114,
0.022385731,
-0.03191524,
0.07936398,
0.017057689,
-0.019363858,
0.01522866,
-0.022319462,
0.004718366,
0.0053976253,
-0.0017660739,
-0.014486445,
-0.02490396,
0.016116668,
-0.021537486,
0.014446683,
-0.045142572,
-0.026600452,
0.008548725,
0.017746888,
0.0008548726,
0.018833704,
-0.042968944,
0.015931113,
0.027170368,
0.0019400305,
0.017985458,
-0.04461242,
-0.0010619637,
0.017773397,
-0.0017213422,
0.011226,
-0.042730372,
0.0037674035,
-0.0021968237,
-0.029821135,
-0.016660074,
0.018316804,
-0.022345971,
-0.024228016,
-0.012697177,
0.0335057,
0.035414256,
0.0048210835,
0.0036679998,
-0.028469244,
-0.024267778,
-0.0033167729,
0.005255147,
-0.009065625,
0.0033747584,
-0.0067528305
] |
The African green monkey (AGM) is one of many African species endemically infected with simian immunodeficiency virus (SIV). Like the other natural hosts, AGMs do not succumb to AIDS and understanding the basis for this resistance to disease progression would be of enormous theoretical and practical importance. Early efforts by our group that concentrated on identifying immune mechanisms presumed to keep the virus under control failed to find any obvious candidates. The presumption of virus control was invalidated by the finding that SIVagm replicates in AGMs with the same vigor as HIV-1 does in humans. Focus therefore shifted to identifying possible immunopathologic | [
-0.014487706,
-0.020717552,
-0.0068992237,
-0.023236,
-0.027888503,
0.02472056,
-0.014487706,
-0.0033733954,
-0.028604273,
-0.0046193646,
0.017576119,
-0.0037644177,
0.023978282,
-0.0140900565,
-0.019829469,
0.0066705747,
0.05089917,
0.0004365863,
-0.0114523135,
0.005311938,
-0.021420067,
0.018914875,
-0.003273983,
-0.028763333,
0.0062928074,
0.020929633,
-0.0016452759,
-0.033482112,
-0.020505473,
0.011346273,
-0.018225614,
-0.017562864,
-0.0041488125,
0.013904487,
-0.012327143,
-0.024601266,
0.009377907,
-0.008834452,
0.016343405,
-0.018437695,
0.0027586953,
0.011478824,
0.0032557575,
-0.005921668,
0.004115675,
0.022374427,
-0.0027934895,
-0.002760352,
-0.040666316,
0.015203476,
0.010769681,
0.009073042,
-0.00657779,
0.01850397,
-0.018517224,
0.010345521,
-0.006103924,
-0.0015674029,
0.0075155804,
-0.026085824,
-0.019352289,
-0.012413301,
-0.019948764,
0.0089338645,
-0.014898611,
0.014646767,
0.004804935,
-0.016396426,
0.015322771,
0.0016883546,
0.024389185,
0.02633767,
-0.023222746,
-0.008098801,
0.026496729,
-0.0070847934,
-0.046896163,
0.0129633825,
-0.0137056615,
0.0003711398,
0.010087049,
-0.02480009,
-0.028180113,
0.024733815,
0.017695414,
0.007031773,
0.015442066,
0.022162346,
0.029717693,
-0.0044238535,
-0.016847095,
0.017695414,
0.019153465,
0.026920889,
-0.031705942,
0.019630643,
-0.0014489363,
0.0105642285,
0.00615363,
-0.020492218,
0.0054345466,
0.007151068,
0.011525216,
-0.014911866,
-0.011538471,
0.0019501407,
0.008953747,
0.0019915625,
0.008807942,
-0.022825096,
-0.013195345,
0.010796191,
-0.018676285,
-0.054822646,
0.0030420206,
0.0021274262,
0.029160982,
0.0015234957,
-0.00073233835,
-0.015468576,
0.0060972963,
-0.010696779,
0.028418703,
-0.007628248,
0.024521736,
0.01243981,
-0.020465707,
-0.025210995,
-0.010491326,
-0.018583499,
0.041594166,
0.013168835,
0.015044416,
0.019007659,
-0.030380443,
0.018225614,
-0.022334661,
-0.0052721733,
-0.0032756398,
-0.0046259924,
0.02604606,
0.03594754,
-0.0058355103,
-0.0007248824,
-0.003684888,
0.013665897,
0.0038870266,
-0.00791323,
-0.010975134,
-0.009046532,
-0.014938376,
-0.014726296,
0.010471444,
-0.017907495,
0.026244884,
0.011916238,
-0.009464065,
0.024627775,
-0.050368972,
0.0014265685,
-0.005129682,
0.001984935,
0.007250481,
0.018676285,
0.0017562865,
0.024283146,
0.006458495,
0.010584111,
-0.0039267913,
-0.014076802,
0.000022704351,
0.031202251,
-0.0038472614,
0.045385092,
0.0013114158,
0.0509787,
0.0026609397,
0.00420846,
-0.0026907634,
-0.018729303,
-0.0059382366,
0.05206561,
0.009947872,
-0.00078204455,
-0.023978282,
-0.00056582247,
0.010126814,
0.0017711984,
0.018835343,
-0.007946367,
-0.0129435,
-0.007979506,
-0.0037014566,
-0.028975412,
-0.6421779,
-0.02556888,
0.021420067,
0.014885357,
0.022639526,
0.010391914,
0.03199755,
-0.010524464,
-0.03390627,
0.022758821,
-0.020015039,
0.00066192116,
0.017377295,
-0.023752946,
0.013334522,
-0.02246721,
0.00868202,
-0.020505473,
-0.0018656402,
0.007747543,
-0.019670408,
0.0066871434,
0.00043368677,
0.020956142,
0.0048347586,
-0.009841831,
0.01916672,
-0.010888976,
0.0033767093,
0.047479384,
-0.010623876,
0.03220963,
0.015375791,
-0.01569391,
0.05487567,
-0.0012476261,
-0.02246721,
0.022626271,
0.009656262,
0.031573392,
-0.0062629837,
-0.002458801,
-0.005762608,
-0.016396426,
-0.014805826,
0.03321701,
0.011286626,
0.00868202,
0.016290385,
-0.020478964,
0.017218234,
0.018490715,
-0.024044557,
-0.00020897323,
0.009927989,
-0.011173958,
0.01892813,
-0.011664393,
0.027199244,
0.020147588,
0.0042813625,
-0.0050567794,
0.0031513744,
-0.0044669323,
-0.014898611,
0.0070781657,
-0.011425803,
0.019763194,
0.0025615273,
-0.02408432,
0.019325778,
0.019855978,
-0.028286153,
0.022825096,
0.008065662,
0.019471584,
-0.011598119,
-0.014315392,
-0.027119715,
0.008032525,
-0.009589987,
0.007952996,
-0.014991396,
-0.0074625607,
0.019816214,
-0.020531982,
-0.022917882,
0.0031994237,
-0.012380162,
0.013851467,
0.019683663,
-0.002117485,
-0.0063325725,
-0.030062322,
0.00038170235,
0.00418195,
-0.0015972266,
0.005852079,
-0.020863358,
-0.0038936539,
-0.00860249,
-0.01802679,
0.0037710452,
-0.0014911867,
0.00857598,
0.012830832,
-0.035761967,
0.0183184,
0.064101145,
-0.019882489,
-0.005626744,
-0.0022318093,
0.030459972,
-0.0075818556,
-0.0072040884,
-0.03329654,
0.012658518,
0.0038472614,
0.022440702,
-0.030910641,
0.000894712,
-0.0057990593,
0.005421292,
0.005586979,
0.0049209157,
-0.0010612278,
0.005487567,
-0.039499875,
-0.02448197,
-0.0019435133,
0.0016808987,
-0.009218847,
0.005199271,
-0.0007120416,
0.04843374,
0.017801454,
0.005997884,
0.015402301,
-0.014275626,
-0.010690151,
-0.0077873077,
-0.0145937465,
0.013586367,
0.006574476,
-0.021579128,
-0.020187354,
0.0014978141,
-0.0072173434,
0.010106931,
-0.027331794,
0.021194732,
-0.0037743591,
0.0007613336,
0.01651572,
0.012804323,
-0.016794074,
-0.00852296,
-0.03881062,
0.008251233,
0.0045033838,
0.0154553205,
0.012009023,
-0.005739412,
0.0029525496,
-0.006196709,
-0.0051661334,
-0.012187965,
0.030353932,
-0.03250124,
-0.04758542,
-0.01688686,
-0.021420067,
-0.01635666,
0.034675058,
0.021194732,
0.003472808,
-0.00097341347,
-0.019723428,
-0.029267022,
0.014805826,
0.012771185,
-0.01627713,
0.0036020442,
-0.0077674254,
0.0536297,
-0.0052655456,
0.02289137,
-0.0035490242,
0.019935507,
0.047267303,
0.0025814096,
0.023527611,
-0.0041057337,
0.011551726,
-0.017098939,
-0.01874256,
-0.0008798001,
0.025449585,
0.024588011,
0.03395929,
0.0028763332,
-0.022811841,
0.0071775783,
-0.023978282,
0.03544385,
-0.019259503,
0.009265239,
-0.025051935,
0.011226978,
0.025104955,
0.005205898,
0.011200468,
0.018676285,
-0.008264488,
0.01265189,
-0.0015292948,
0.0047519146,
-0.007827073,
-0.019299269,
-0.0020462393,
-0.018914875,
0.015972266,
-0.009066415,
-0.028286153,
-0.0164627,
0.030963661,
-0.010285874,
0.040083095,
-0.00860249,
-0.03608009,
-0.021910502,
-0.011226978,
0.015256496,
-0.007263736,
0.021048928,
0.009570104,
0.018517224,
-0.01225424,
0.020492218,
-0.00009578803,
-0.022122582,
0.01898115,
0.03581499,
0.0057990593,
0.020028293,
-0.010511209,
0.01304954,
0.02604606,
-0.007402913,
0.037405588,
-0.024972405,
-0.0041488125,
-0.004546462,
0.00910618,
0.0074890708,
0.011273371,
0.008900727,
-0.004549776,
0.029107964,
0.01736404,
0.0040494003,
-0.008556098,
-0.004046086,
-0.003118237,
0.008112055,
0.007827073,
0.0026725377,
-0.008715157,
0.0065048872,
0.010782937,
-0.0056101754,
-0.0024505167,
-0.00066440646,
-0.016025286,
0.012512713,
0.007508953,
-0.01728451,
-0.018994404,
0.006716967,
-0.0015185251,
-0.03271332,
-0.0347811,
0.004079224,
-0.0073035005,
-0.0062000225,
-0.0007045857,
-0.020903124,
-0.0038472614,
-0.0074758157,
0.01717847,
-0.0069787535,
0.024760325,
-0.00396987,
-0.002198672,
-0.009497202,
-0.020094568,
0.008688647,
-0.010345521,
0.0126784,
0.0029376377,
-0.000045745255,
-0.006034335,
-0.011743923,
-0.014858847,
0.007416168,
0.009165827,
0.0014696473,
-0.020677788,
-0.00073068147,
0.020492218,
-0.009358024,
-0.019882489,
0.007124558,
-0.01230726,
0.004944112,
0.030963661,
-0.02498566,
0.0069721257,
0.023408316,
-0.0114987055,
0.0019054051,
-0.045994822,
-0.008191586,
-0.024892876,
0.05198608,
0.00027462686,
0.00043948583,
0.010809446,
0.023673415,
0.017880984,
-0.008900727,
-0.03316399,
0.029956283,
-0.017867729,
-0.019590879,
-0.013427307,
0.02294439,
0.0046226787,
0.020730808,
0.015587871,
-0.005374899,
-0.010524464,
-0.0056665093,
0.011770433,
0.011783688,
0.0007642331,
0.008456685,
0.026509983,
0.011101056,
-0.009768929,
0.012240985,
0.006160258,
-0.02554237,
-0.027755953,
-0.0060442765,
-0.015561361,
-0.019140208,
0.01762914,
-0.0035158866,
-0.024230126,
-0.0014265685,
0.014355157,
0.01794726,
-0.010199716,
0.030194873,
0.03517875,
0.0066772024,
-0.013460444,
0.023408316,
-0.0038174377,
-0.009305005,
0.002500223,
0.0077409153,
-0.040268667,
0.044801872,
-0.009232102,
-0.012658518,
-0.0025996354,
0.031122722,
0.01651572,
-0.02586049,
-0.0037710452,
-0.013314639,
-0.01739055,
-0.025476094,
-0.019325778,
0.012214475,
-0.009424299,
-0.028736822,
-0.008184957,
0.0013528377,
-0.006219905,
-0.0054378607,
-0.005775863,
0.027305285,
-0.029214002,
0.008344018,
0.003800869,
-0.0031894825,
0.0027421266,
-0.0039665564,
-0.01797377,
0.008052408,
0.007999388,
0.0057162154,
-0.017801454,
-0.011505333,
-0.021327283,
0.006461809,
0.0076746405,
0.01254585,
-0.028180113,
-0.015203476,
0.011167331,
0.009205592,
-0.0087416675,
0.017059175,
0.013917741,
-0.0022467212,
-0.01236028,
0.024588011,
0.019060679,
-0.01159149,
-0.013486954,
0.0126982825,
-0.039605916,
0.011816826,
-0.028551253,
0.0025797528,
-0.010272619,
-0.0031464037,
0.00041981044,
-0.045279052,
-0.03250124,
0.014434687,
-0.025529115,
0.0132086,
-0.019365543,
0.030088833,
0.0107564265,
0.027172733,
0.012618752,
0.01797377,
-0.039261285,
-0.0131290695,
-0.021128457,
0.02389875,
0.014434687,
-0.002985687,
0.013493582,
0.030433463,
0.009411044,
-0.024919385,
-0.019935507,
0.010995016,
0.039102226,
0.007694523,
-0.016078306,
-0.015389046,
0.0025946647,
0.009218847,
0.012128318,
0.0002930596,
-0.009696026,
-0.006945616,
-0.012028906,
0.020028293,
-0.0026891066,
0.0035457104,
-0.028312663,
0.0066473787,
0.019020913,
0.013917741,
0.003419788,
-0.015190221,
0.0066970848,
0.0028630784,
0.01704592,
-0.028445214,
-0.013361032,
-0.008675393,
0.020068059,
0.028180113,
0.023289021,
0.018464204,
-0.0121482005,
0.030884132,
0.027172733,
0.010166579,
-0.008953747,
-0.003814124,
0.006196709,
-0.011843336,
0.0028448526,
-0.00020762703,
-0.0006403818,
0.0022980843,
-0.004602796,
0.017032664,
-0.0065148287,
-0.0037843003,
-0.030698562,
-0.005487567,
-0.033243522,
0.0038903402,
0.010047284,
0.008039153,
0.0042184014,
-0.045066975,
-0.010696779,
0.022559997,
0.031308293,
0.004403971,
0.00056499406,
0.013221854,
0.009358024,
-0.00034214449,
-0.0013959163,
0.023752946,
-0.014235862,
-0.009298377,
-0.013732172,
0.013771937,
0.024044557,
-0.010186462,
0.0021406813,
0.020677788,
-0.01921974,
0.017880984,
0.021393558,
-0.011664393,
-0.010597366,
0.020280138,
-0.023315532,
-0.021526108,
-0.015919246,
-0.020704297,
-0.03735257,
-0.0025814096,
-0.012168082,
0.0011258459,
0.0071643232,
-0.004771797,
-0.00793974,
0.035152238,
0.008503078,
0.038041826,
-0.007694523,
0.022652782,
-0.0020594944,
-0.006746791,
-0.037644178,
0.013864722,
0.0007493213,
0.009311632,
0.0159325,
0.020081313,
-0.002129083,
-0.041885775,
0.030327423,
0.015428811,
-0.006050904,
-0.03401231,
0.044139124,
0.016197601,
0.002023043,
-0.019749938,
-0.01693988,
-0.014911866,
0.027437834,
-0.0037180253,
0.021367047,
0.0042548524,
-0.019590879,
-0.029081453,
0.01212169,
0.021618892,
0.00567645,
-0.009305005,
-0.030698562,
-0.009450809,
-0.028524743,
-0.010159952,
0.02485311,
0.0040030074,
0.014699786,
0.011147449,
-0.025184486,
0.0002864321,
-0.011458941,
-0.0023477904,
0.0042681075,
-0.008489822,
0.029664673,
0.0068064383,
-0.0058752755,
-0.00004553815,
-0.011405921,
0.0067931833,
0.01760263,
0.005958119,
0.00080524076,
-0.02540982,
-0.006905851,
0.020797083,
0.044033084,
0.0041885776,
0.017867729,
-0.012910362,
0.009662889,
-0.029585142,
-0.030168362,
0.0048513273,
-0.008536215,
0.015959011,
-0.020160843,
0.009550222,
0.015362536,
0.015866226,
0.0045033838,
0.0025979786,
0.02487962,
-0.004483501,
0.014553982,
0.007654758,
-0.0073432657,
0.0009510457,
-0.010332267,
0.0038704576,
-0.031228762,
0.012512713,
-0.005086603,
-0.043343823,
-0.042999193,
-0.0021340537,
0.020280138,
-0.006090669,
-0.012711537,
0.04888441,
-0.008171703,
0.011545098,
-0.016661525,
-0.01257236,
0.020545239,
-0.01747008,
-0.028021054,
0.013480327,
-0.0115716085,
0.0068462035,
0.014779316,
0.010405169,
0.011207096,
-0.028551253,
-0.026934145,
-0.015760185,
-0.0030469913,
0.0000070158258,
-0.018291889,
0.0017811395,
-0.0321301,
-0.013122442,
-0.0003332388,
-0.014235862,
-0.020916378,
-0.0036484366,
0.009782184,
-0.010835956,
0.003129835,
-0.015070926,
0.020744063,
0.011657766,
-0.021950267,
-0.03183849,
-0.0100605395,
-0.0261521,
0.03608009,
0.010855839,
0.017960515,
-0.028736822,
-0.002826627,
-0.058162905,
0.0020628083,
-0.0137056615,
0.01784122,
0.004397344,
0.008410293,
0.0017662277,
0.00639222,
0.019126954,
0.008754922,
-0.011094429,
-0.018119574,
0.023448082,
0.00873504,
0.02538331,
-0.00091210916,
-0.0037809864,
0.016078306,
0.025780959,
0.00022906283,
-0.014050292,
0.013142325,
-0.02379271,
0.006103924,
-0.0066705747,
0.015919246,
0.01582646,
-0.010882349,
-0.002394183,
-0.0008325792,
-0.037458606,
0.016131325,
-0.002762009,
0.0077276602,
0.002407438,
0.0026112334,
0.004930857,
0.018530479,
-0.02384573,
-0.011816826,
0.020200608,
-0.004877837,
0.027729444,
0.018185848,
0.0093646515,
-0.007774053,
-0.01297001,
-0.01180357,
-0.0061006104,
0.014275626,
-0.0069389883,
0.007813818,
0.021698423,
-0.0018556989,
-0.0040030074,
-0.02342157,
0.023408316,
-0.019206483,
0.005709588,
-0.0018175908,
-0.01603854,
-0.04819515,
0.015481831,
0.008768178,
0.014580491,
0.0090531595,
0.013732172,
0.0036683192,
0.00052108685,
-0.00844343,
-0.0013188717,
0.014898611,
0.0060310215,
-0.017112195,
0.0013354404,
-0.004539835,
-0.019657154,
0.009775557,
-0.022732312,
0.0035225141,
0.1861001,
0.006627496,
0.015229986,
-0.0029840302,
-0.037193507,
-0.00024998086,
0.016661525,
0.01569391,
0.007860211,
0.021287518,
0.013148952,
0.017085684,
-0.005116427,
0.00436752,
-0.01643619,
-0.011637883,
-0.03411835,
-0.010597366,
-0.010842584,
-0.005099858,
0.018172594,
-0.00092784944,
0.012506085,
0.0002706918,
0.017615885,
-0.0018871796,
-0.01845095,
0.01275793,
0.003459553,
-0.010630503,
-0.016555484,
-0.01678082,
0.0056466265,
0.008834452,
-0.006431985,
-0.010544347,
-0.020478964,
-0.01209518,
0.0073366384,
0.014832336,
-0.021963522,
0.005275487,
-0.022096071,
-0.004824817,
-0.012830832,
0.03353513,
-0.0014605344,
-0.016820585,
0.0040825377,
-0.0016626731,
-0.036954917,
-0.0056665093,
0.0021340537,
0.01802679,
-0.010186462,
0.007860211,
0.016528975,
-0.01797377,
-0.0063988473,
0.023739692,
-0.017867729,
0.010511209,
0.003787614,
0.03430392,
0.001656874,
0.04936159,
-0.019776449,
0.0076746405,
0.009563477,
-0.014487706,
-0.005606862,
-0.040825374,
-0.007469188,
-0.01670129,
-0.010995016,
-0.0048446995,
0.03541734,
0.005901785,
0.01916672,
-0.014076802,
-0.021115202,
-0.010365404,
-0.027782464,
0.011730668,
-0.017774945,
-0.022679292,
0.03891666,
-0.008907354,
-0.016502466,
0.019113699,
-0.013486954,
-0.008158448,
-0.021393558,
-0.0069721257,
-0.00412893,
0.011260116,
-0.0014389951,
0.0008524617,
0.022135837,
-0.026165355,
-0.017774945,
0.05055454,
0.010928741,
-0.0033617974,
0.005577038,
0.015322771,
-0.018769069,
0.0063822786,
-0.002826627,
-0.029134473,
-0.017430315,
-0.03255426,
0.005550528,
-0.014898611,
0.00828437,
0.015508341,
0.017006155,
-0.014567236,
0.012048787,
0.0017016096,
-0.0036782604,
-0.018185848,
-0.0043940297,
0.0007414511,
-0.011922865,
-0.03568244,
-0.020717552,
0.03382674,
-0.008569352,
-0.0113794105,
-0.00894712,
-0.0135134645,
-0.01230726,
-0.008728412,
0.010478071,
0.016635016,
0.021751443,
-0.014938376,
0.0051495642,
-0.010895603,
-0.000549668,
-0.009039905,
0.021579128,
-0.014779316,
0.021605637,
-0.020293392,
0.023050431,
0.029876752,
-0.00939779,
-0.0075420905,
-0.01696639,
-0.019193228,
0.0011846649,
0.006236474,
0.016621761,
-0.014607001,
0.00017759619,
-0.014222607,
-0.0012476261,
0.023686672,
-0.010888976,
0.026244884,
0.011087801,
-0.03483412,
-0.010816074,
0.022639526,
-0.16690686,
0.005421292,
0.020094568,
-0.0039102226,
0.017867729,
0.013891232,
0.023646906,
-0.0016427906,
-0.015534851,
0.009497202,
0.030194873,
0.005759294,
-0.026589515,
-0.021075437,
0.015269751,
-0.0030486481,
-0.022493722,
0.012453065,
0.018093064,
-0.0019136895,
-0.0055339593,
-0.028710313,
-0.0143286465,
-0.032527752,
-0.013427307,
0.010922113,
-0.00394336,
-0.00095933006,
-0.020651277,
-0.02493264,
-0.0069522434,
0.001643619,
0.027941523,
-0.011240234,
0.009457437,
0.002500223,
0.004841386,
0.015017906,
-0.006839576,
-0.006309376,
0.021724932,
0.014686531,
-0.009073042,
-0.0087416675,
-0.00636571,
0.011293253,
0.024813345,
0.021764698,
0.010961878,
0.00044487067,
0.03581499,
-0.013188717,
0.030751582,
0.014129821,
0.013228483,
0.009662889,
0.001105135,
-0.0006892596,
0.009921362,
-0.014076802,
-0.014553982,
-0.022069562,
0.02559539,
-0.013427307,
0.014235862,
-0.041063964,
-0.020412687,
-0.011876473,
-0.027782464,
0.023567377,
-0.031918023,
0.022878116,
-0.009722536,
-0.03459553,
0.019206483,
0.026085824,
-0.031122722,
0.0090531595,
-0.022374427,
-0.005487567,
-0.009165827,
0.00578249,
-0.014050292,
-0.0011440715,
0.0023825848,
-0.0028862746,
0.011465568,
-0.012214475,
-0.0024969091,
0.00036865447,
0.015137201,
-0.024203615,
-0.0023726437,
-0.029558633,
0.018543733,
0.01670129,
0.008324135,
0.0015674029,
0.003288895,
-0.015322771,
0.0051097996,
0.0015027848,
-0.019445073,
-0.014567236,
0.011757178,
-0.028683804,
0.0045265798,
-0.006329259,
0.04721428,
-0.010292501,
-0.014832336,
0.003051962,
-0.009324887,
0.023143217,
-0.022149092,
0.007601738,
0.002500223,
-0.023540866,
-0.0044901287,
-0.028551253,
0.03867807,
-0.0027852051,
-0.010378659,
0.007840328,
-0.0054908805,
-0.0055836653,
-0.12820229,
-0.018040044,
-0.0060045114,
0.015229986,
-0.0035954167,
0.00907967,
0.004138871,
0.010425052,
-0.015587871,
0.010219599,
-0.03700794,
-0.009629752,
0.012453065,
0.0018474145,
0.018238869,
0.015733676,
-0.010577484,
-0.0005741069,
-0.02530378,
0.0024604579,
0.0035490242,
-0.011313136,
0.00049374846,
0.0014042007,
0.005010387,
0.035390828,
-0.008536215,
0.028789843,
0.0061105513,
0.024495225,
0.025873745,
-0.014262372,
0.022202112,
-0.015733676,
-0.03183849,
-0.00080648344,
0.0044669323,
-0.012413301,
0.023010666,
0.005106486,
-0.0044768737,
0.012764557,
0.016608505,
0.015548106,
0.025449585,
-0.007899975,
0.0056631956,
0.0073233834,
-0.0012459692,
-0.030221382,
-0.01696639,
-0.006040963,
-0.038837127,
-0.011333019,
0.013314639,
-0.037909277,
0.0054511153,
0.042654566,
0.0012716508,
0.017059175,
0.011313136,
0.002616204,
-0.008940492,
-0.0073962854,
0.012897108,
0.0024919384,
-0.0061204927,
-0.006183454,
0.030327423,
-0.027861994,
0.023805967,
-0.01291699,
-0.010425052,
-0.021605637,
-0.005457743,
0.019140208,
0.0046889535,
-0.024349421,
-0.006491632,
-0.008701903,
-0.022745566,
-0.013599622,
0.0075155804,
-0.012453065,
0.018225614,
0.006166885,
0.011107683,
-0.0024256636,
0.00045025552,
-0.002407438,
-0.00442054,
0.0024637717,
-0.01587948,
-0.02469405,
-0.022016542,
0.009530339,
-0.010570856,
-0.012592243,
0.019020913,
0.018954638,
-0.030725071,
0.0006018595,
-0.057473645,
0.00833739,
-0.0029525496,
-0.0183184,
-0.00578249,
-0.01654223,
0.0055604693,
-0.037670687,
0.019524604,
-0.012048787,
-0.014898611,
0.020399433,
-0.02654975,
0.022427447,
-0.034516,
0.0020313275,
0.05052803,
0.00479168,
0.020346412,
0.022692546,
0.005997884,
0.012936872,
0.0026394003,
0.027543874,
0.0042184014,
0.025953274,
-0.010292501,
0.038519006,
-0.0075288354,
0.010822701,
-0.00428799,
-0.022692546,
-0.007873465,
0.006932361,
-0.0026791652,
0.0064783776,
0.022957647,
0.006627496,
0.023090197,
0.05402735,
-0.022361172,
-0.017761689,
0.008589235,
-0.003065217,
0.013268247,
0.0079264855,
-0.013546602,
0.0012965039,
0.009967754,
-0.03494016,
0.0150974365,
0.0147130415,
-0.03446298,
-0.029638162,
-0.024945896,
0.001143243,
0.02437593,
0.004997132,
-0.0012335427,
0.001381833,
0.011730668,
0.0054776254,
0.013109188,
0.006352455,
0.010405169,
-0.0045796,
-0.038651556,
0.019047424,
0.013254992,
-0.007614993,
-0.022135837,
-0.013679152,
0.0045199525,
-0.014275626,
-0.025635155,
-0.0031513744,
0.008410293,
0.014673277,
-0.00073233835,
-0.002828284,
-0.010729916,
-0.011279998,
-0.011697531,
0.007840328,
0.025502605,
0.010000892,
-0.0046259924,
0.036928408,
0.012274123,
-0.0025300467,
-0.01678082,
0.01789424,
-0.0074095405,
0.0077276602,
0.007257108,
0.015070926,
-0.0028117152,
0.021565873,
0.038890146,
0.040798865,
0.01688686,
-0.009430927,
0.0064253574,
-0.014063546,
-0.009020022,
0.0154553205,
-0.028392194,
-0.048804883,
-0.024415696,
0.001787767,
0.011982513,
0.0031927961,
0.003983125,
-0.007011891,
-0.01262538,
0.017165216,
-0.015852971,
0.010431679,
-0.02567492,
0.0074294233,
0.025343545,
0.0150974365,
-0.0058686477,
-0.009543594,
-0.018901618,
0.03722002,
0.015945755,
-0.041806247,
-0.0031845118,
-0.021221243,
0.002195358,
-0.009967754,
-0.0022069563,
-0.013142325,
-0.023912005,
-0.023408316,
0.020823592,
0.014938376,
-0.010325639,
0.058056865,
0.0052821143,
0.009099552,
0.015760185,
-0.0366368,
0.010623876,
0.008748295,
0.014553982,
-0.021101948,
-0.027106458,
0.010153324,
-0.03414486,
0.011770433,
-0.013453817,
-0.03843948,
0.02623163,
-0.007250481,
0.01680733,
-0.024110831,
-0.011412548,
0.042415977,
-0.0017861102,
0.037670687,
0.0120023955,
-0.0020280138,
-0.004403971,
0.019842723,
-0.0066506923,
-0.016131325,
-0.026536494,
0.003787614,
0.018663028,
-0.041673694,
-0.017430315,
-0.008953747,
-0.027994543,
-0.013427307,
0.0012617096,
0.028445214,
-0.007243853,
0.004722091,
0.0109486235,
-0.0147130415,
-0.014819081,
0.023355296,
-0.01760263,
-0.037166998,
-0.023620397,
-0.008317508
] |
This article describes the development and validation of the S-LANSS score, a self-report version of the Leeds Assessment of Neuropathic Symptoms and Signs pain scale. The S-LANSS aims to identify pain of predominantly neuropathic origin, as distinct from nociceptive pain, without the need for clinical examination. Two hundred patients with chronic pain were asked to complete the S-LANSS unaided. A researcher then administered the S-LANSS scale and the Neuropathic Pain Scale (NPS) in interview format. An independent clinician determined the pain type (neuropathic versus nociceptive | [
0.0026545536,
0.011304589,
0.06325628,
-0.02998084,
-0.022032622,
-0.0005744097,
-0.0120870555,
-0.003826538,
-0.017845739,
-0.01521006,
-0.0037887876,
0.0036206257,
-0.013418622,
0.02303473,
0.0080168545,
0.011345771,
0.04093538,
0.009458241,
-0.004639892,
-0.006318078,
-0.017832011,
-0.0001619415,
-0.008215903,
-0.012382197,
0.0011694107,
-0.0013212711,
-0.0022736157,
-0.042692497,
-0.021785527,
0.0005877082,
0.015278698,
-0.015086513,
-0.012327287,
0.0019235647,
-0.022279719,
0.0036343532,
-0.009169964,
-0.01586898,
-0.0027334867,
-0.03080449,
0.011839961,
0.008257085,
-0.0052850842,
-0.008167857,
0.013535306,
-0.0028467386,
-0.013562761,
-0.01526497,
-0.021195246,
0.030996675,
0.01936949,
0.0054395185,
-0.033824537,
-0.0012612132,
0.009725927,
-0.019081213,
0.042170852,
0.01460605,
0.021703163,
-0.01674754,
-0.016129803,
0.022307172,
-0.021003062,
0.020755967,
-0.008998371,
-0.017584916,
-0.010844718,
0.005161537,
0.005803297,
-0.0067539257,
0.020508872,
0.03950772,
-0.028168812,
-0.007502074,
0.01696718,
0.020110775,
0.019506766,
-0.033961814,
0.009794565,
0.006125893,
0.0069941566,
-0.014111861,
-0.030886855,
0.00883364,
0.012684202,
-0.014482503,
0.007865853,
0.0052816523,
-0.032259606,
0.004238363,
0.0045437994,
0.021003062,
0.010645669,
-0.0015460587,
0.0016756118,
0.0246683,
-0.0064896713,
-0.0017983014,
-0.004224635,
-0.014276591,
-0.01581407,
0.01581407,
-0.014866873,
-0.02151098,
-0.007529529,
-0.02620578,
-0.020302959,
0.012560654,
0.011448728,
0.01359708,
-0.028800277,
0.029788656,
-0.012807749,
0.0028673296,
0.030118115,
-0.03063976,
0.031600684,
-0.014811963,
-0.0037544689,
-0.029678836,
0.018490931,
0.0023233779,
0.01460605,
0.0028158517,
0.026068505,
0.019520493,
-0.011338907,
-0.0019184168,
-0.051230997,
-0.0052713566,
-0.0060847104,
0.022581723,
0.027235342,
0.00035498434,
-0.0020694192,
-0.00049461867,
-0.002965138,
-0.012862659,
-0.03780551,
-0.017763374,
-0.0054669734,
0.020440234,
-0.029294467,
-0.0025842001,
0.006887769,
0.030502485,
0.03146341,
0.013253893,
0.012533199,
0.000004695365,
0.012437107,
-0.039370444,
-0.012114511,
-0.008360042,
-0.008147266,
0.0032551314,
0.022156172,
0.039260626,
-0.022018896,
-0.0005019114,
-0.018669387,
-0.005549338,
0.003833402,
-0.024160385,
-0.021318793,
0.023597557,
0.023995655,
-0.011956645,
0.009334694,
-0.0029582742,
-0.024229022,
0.023556374,
-0.019520493,
0.031930145,
-0.0072206603,
-0.014276591,
0.0020694192,
0.006338669,
-0.0055184513,
-0.023021003,
-0.0136451265,
0.019822497,
0.018998848,
0.0022324333,
-0.015580703,
0.012059601,
0.019602858,
-0.0093415575,
-0.0012045873,
-0.0011891439,
-0.002774669,
-0.0041216793,
0.00771485,
-0.026192052,
-0.62817,
-0.02609596,
0.04961115,
0.0031899258,
0.011688959,
0.021291338,
0.0019064053,
-0.004797758,
-0.014235408,
0.027454982,
-0.01293816,
0.005556202,
0.011963508,
-0.025409587,
-0.004372206,
-0.005528747,
-0.025972413,
0.009279784,
0.037668236,
-0.012395925,
-0.005384608,
0.028965006,
0.0045987093,
0.0015529224,
0.013967722,
0.010679988,
0.024860486,
-0.032589063,
0.018889029,
0.0071863416,
-0.033275437,
0.00058427633,
-0.0037956513,
0.0056522945,
0.048787504,
-0.026164599,
-0.020659873,
0.018120289,
0.03173796,
0.026164599,
-0.041237384,
-0.012739112,
0.0008022003,
-0.009183692,
-0.03934299,
0.011853688,
0.009574925,
-0.0000023845482,
-0.002972002,
-0.01625335,
0.008614001,
-0.0020539758,
-0.0064038746,
0.02494285,
0.010281891,
-0.024476117,
0.03643276,
-0.004804622,
0.00888855,
0.018957665,
-0.006699016,
0.0020007817,
-0.010961401,
-0.03118886,
-0.002100306,
0.0064622164,
-0.022060078,
-0.009533742,
0.0005413779,
-0.00932783,
0.01009657,
0.016116075,
-0.0024709485,
0.012011555,
0.009018961,
0.019438127,
0.006561741,
0.02959647,
-0.014523686,
-0.03009066,
-0.010693716,
0.009794565,
-0.021593343,
0.00043541886,
0.029541561,
-0.0068328585,
-0.0073991176,
0.02374856,
0.0005619692,
-0.0037887876,
-0.00051134906,
0.0075981664,
-0.027619712,
-0.03398927,
-0.009204282,
0.041402113,
-0.0039809723,
0.0017862897,
-0.0020316688,
-0.01504533,
-0.022650361,
-0.0030852535,
0.031216314,
-0.021785527,
0.036185667,
-0.0031676185,
-0.015072785,
0.030063206,
0.03217724,
-0.01920476,
0.0014250851,
-0.017722191,
-0.020865787,
-0.014784507,
0.005068876,
-0.018477203,
0.020563781,
0.007419709,
-0.0064038746,
-0.040358823,
-0.010124025,
0.010069115,
0.028360996,
-0.0073236166,
-0.00012837349,
0.018408565,
-0.00285875,
0.0014242271,
0.0005988618,
-0.02314455,
-0.025382131,
-0.023872107,
0.0048355088,
-0.029294467,
0.0068465862,
0.0019733268,
0.017022088,
0.0017022089,
0.0079688085,
-0.041182473,
-0.028251177,
-0.003050935,
-0.0058170245,
-0.020810876,
-0.010151479,
-0.02259545,
-0.01669263,
0.003562284,
0.005127218,
0.0035897389,
-0.023940744,
-0.02336419,
-0.0155395195,
0.0019493038,
-0.029074825,
-0.005213015,
0.013404895,
-0.02336419,
-0.014853145,
-0.009554334,
-0.008284541,
-0.006153348,
-0.021771802,
-0.013116618,
-0.016980907,
-0.03289107,
0.019520493,
0.03967245,
0.00016633858,
-0.035169832,
-0.027756987,
-0.017845739,
-0.016321987,
0.0080168545,
0.0022856272,
-0.013514715,
0.020055864,
-0.025107581,
0.017035816,
-0.008236495,
0.0020694192,
0.018285017,
0.0058307517,
0.015182605,
0.026713697,
0.011393817,
0.039864633,
-0.000024974917,
-0.006959838,
-0.011249679,
-0.0028518862,
0.012032146,
-0.022252264,
0.020934423,
-0.045877274,
0.03063976,
-0.006201394,
0.0024452093,
0.013912812,
0.00039466537,
0.011435,
-0.0042795455,
0.0062219854,
0.00842868,
0.03014557,
-0.015553247,
0.024915397,
-0.016843632,
0.024078019,
-0.00023679923,
0.02292491,
0.004986511,
-0.022403266,
-0.016225895,
-0.014317773,
0.018628206,
0.023556374,
0.011332043,
0.005391472,
-0.0053331302,
-0.0021963986,
-0.01724173,
0.019012576,
0.009238602,
-0.0020642714,
0.021771802,
-0.0021723756,
0.028223721,
0.003071526,
-0.020028409,
0.0033048934,
-0.0037373095,
0.014770781,
0.017900648,
0.0124165155,
0.006850018,
0.033083253,
-0.006637242,
0.029294467,
0.014757053,
-0.01039171,
0.022224808,
0.00020494715,
0.016157256,
0.05499233,
0.008675775,
0.013164664,
0.009396467,
-0.006287191,
0.005775842,
0.008936597,
-0.0027128954,
-0.038052604,
0.0036240576,
-0.00083265814,
-0.006582332,
-0.0028536022,
0.018532112,
0.029239556,
0.010137752,
0.029349376,
0.0038128106,
0.022183625,
-0.001781142,
0.009067008,
-0.026397966,
-0.010933947,
-0.01586898,
0.022005169,
-0.0053091072,
-0.010048524,
0.011688959,
0.0017493971,
-0.020261778,
0.026233235,
-0.00091888395,
0.029349376,
-0.0010733182,
0.03338526,
0.0032414037,
-0.025299765,
-0.011476182,
0.03769569,
0.0029428308,
-0.005744955,
-0.0093415575,
-0.012512608,
0.017200546,
-0.014619778,
0.0060298005,
0.0097671095,
0.01227924,
0.005748387,
0.004035882,
0.009053281,
0.007845261,
0.014427593,
-0.0092935115,
0.0043344554,
-0.0026905884,
0.015196333,
0.005573361,
0.008009991,
-0.020755967,
0.031079039,
0.008195312,
-0.040249005,
-0.020728512,
-0.023226915,
-0.015759159,
-0.000025296657,
-0.004609005,
0.00076230476,
0.012389061,
0.03420891,
0.010206389,
-0.0043859333,
0.011970372,
0.039205715,
-0.003425009,
-0.014036359,
-0.037393685,
0.0036000346,
0.009080735,
0.046261646,
0.005336562,
0.027454982,
0.007687395,
0.019630313,
-0.026837245,
-0.021867894,
-0.015635611,
0.025025217,
-0.00042469424,
-0.025025217,
0.027166706,
0.011386954,
0.026343055,
0.029678836,
0.01537479,
0.017955558,
-0.025025217,
0.0043035685,
-0.0035828752,
0.011256543,
-0.0026528377,
0.021140337,
0.051835008,
-0.0039191986,
-0.007852125,
0.0009652142,
-0.007419709,
0.015278698,
-0.032287057,
-0.03009066,
0.026658788,
-0.0150178755,
0.017530005,
-0.035718933,
0.03063976,
0.008360042,
0.02358383,
0.006558309,
0.00502083,
0.018889029,
-0.00949256,
0.025080126,
0.010295618,
-0.003613762,
-0.0061842347,
0.002723191,
0.018792935,
0.008202176,
0.0019595993,
0.015951345,
-0.03080449,
0.0025842001,
-0.004372206,
0.028196266,
-0.016170984,
-0.0019372922,
-0.000593285,
-0.0011265122,
0.005099763,
-0.014866873,
-0.0045712544,
0.013329394,
-0.014921783,
-0.03912335,
-0.02358383,
0.00008955043,
0.020934423,
-0.014427593,
-0.003449032,
0.014111861,
-0.010343664,
-0.02691961,
0.023666194,
0.024613392,
0.0044957534,
0.02598614,
0.003370099,
-0.0021140336,
0.03025539,
-0.011805642,
0.009883794,
0.012231194,
-0.0119841,
0.023213187,
0.01920476,
0.00045558112,
-0.0048458045,
0.005017398,
-0.041786484,
0.013857902,
-0.017886922,
-0.007913899,
0.010323074,
0.011661503,
-0.0075432565,
0.034730554,
0.006129325,
0.00052979536,
-0.02893755,
0.018641934,
-0.045273267,
-0.011682095,
-0.02314455,
0.012711656,
-0.0064587845,
-0.005954299,
0.0045403675,
0.0059199804,
-0.024613392,
0.0347031,
-0.0002717614,
0.00092832156,
0.005768978,
0.0031882098,
0.018532112,
-0.012780294,
-0.0031315838,
0.03365981,
0.014153044,
-0.0002586774,
-0.011146722,
0.013494124,
-0.010062251,
-0.025656682,
0.028168812,
-0.0038128106,
0.0034129976,
-0.022128716,
-0.0089640515,
0.0043584784,
0.042582676,
-0.005635135,
-0.021030515,
-0.024270205,
0.0035279652,
-0.01794183,
-0.0019287125,
0.00237314,
-0.015663067,
0.00056711695,
0.00480119,
0.0047119614,
-0.0043207277,
0.034428548,
-0.025533134,
-0.041868847,
0.014413865,
-0.016871087,
-0.0011119267,
-0.017639825,
0.0106662605,
-0.005926844,
-0.009863202,
-0.0038093787,
-0.018532112,
-0.002021373,
0.0062185535,
0.039562628,
0.02151098,
0.016404351,
-0.00210717,
-0.0029977409,
0.013507851,
-0.023954472,
-0.0024452093,
-0.028251177,
-0.005213015,
-0.014441321,
0.028168812,
0.026576422,
0.003991268,
0.014770781,
-0.011359499,
0.0127459755,
0.03736623,
-0.0008725537,
-0.028663002,
-0.016953452,
-0.053427394,
0.0032774385,
0.009444514,
-0.002376572,
0.031326134,
-0.046096914,
-0.0067573576,
0.00765994,
-0.016335715,
-0.004025587,
-0.04667347,
0.03659749,
0.006685288,
0.0027592257,
0.018188925,
-0.008730684,
-0.017035816,
-0.015855253,
-0.018230109,
-0.0008991507,
-0.022732725,
-0.010000478,
-0.007467755,
0.00998675,
0.0039226306,
-0.010233845,
0.021909075,
-0.027688349,
0.013144073,
-0.029925931,
0.0033203368,
-0.0005443808,
0.0020848627,
-0.02746871,
-0.006987293,
0.02276018,
0.0051340815,
0.0038093787,
0.016335715,
-0.041155018,
-0.017255457,
0.013219574,
0.0043859333,
-0.0030406392,
-0.010549577,
0.028113902,
0.0047325525,
-0.003428441,
-0.052384105,
0.0051134904,
0.014798235,
-0.026727425,
0.02035787,
0.018134017,
-0.0176261,
-0.004643324,
0.009520015,
0.00881305,
-0.038931165,
-0.04804622,
0.02085206,
0.0037716283,
0.005909685,
-0.02325437,
-0.0154434275,
-0.029157192,
0.02708434,
-0.017145636,
-0.017296638,
-0.010178935,
-0.0014722734,
-0.0006657833,
0.02479185,
-0.03497765,
0.032643974,
-0.002103738,
0.0020351005,
-0.010467212,
-0.007941353,
-0.003668672,
-0.0006391863,
0.0017931535,
0.029733745,
-0.00960238,
-0.020165684,
-0.013549034,
0.042088486,
0.022938637,
0.010226981,
-0.0054669734,
0.04387306,
-0.0064828075,
-0.022746453,
0.028553182,
0.003366667,
-0.0038196745,
0.0071932054,
-0.0060435277,
-0.008325723,
-0.03786042,
0.006493103,
0.026246963,
-0.00045558112,
-0.016294532,
0.006280327,
-0.007742305,
-0.0194244,
-0.013288211,
-0.021785527,
-0.009664154,
-0.033632353,
-0.004399661,
-0.005539043,
-0.015031603,
0.013027389,
0.012141966,
-0.0041457023,
-0.006475944,
0.026164599,
-0.02462712,
0.041511934,
0.016569082,
0.01871057,
-0.011956645,
0.016349442,
-0.00096349826,
-0.032836158,
0.021785527,
-0.011084949,
-0.015086513,
0.0054601096,
0.015855253,
-0.0012749408,
0.00013030392,
-0.028663002,
0.012965615,
0.0017622666,
-0.011524228,
-0.027976627,
-0.024860486,
0.0016018266,
-0.0067299027,
-0.0019355762,
0.00069667015,
-0.016610265,
0.001724516,
-0.013020526,
0.009300375,
0.0014920067,
-0.017859466,
-0.0020127934,
-0.0041045197,
0.0046982337,
0.004777167,
-0.01636317,
-0.016006254,
-0.0017493971,
-0.021236429,
0.0062254174,
0.0015529224,
-0.014866873,
-0.029129736,
-0.024325114,
0.010124025,
0.0045197764,
-0.014509958,
-0.022883728,
0.0047256886,
-0.0062425765,
-0.03637785,
-0.022828817,
-0.02210126,
0.050956447,
0.020865787,
0.008600273,
-0.02910228,
-0.0114693185,
-0.041786484,
0.014537413,
-0.002371424,
0.015525793,
0.02330928,
0.03322053,
-0.013535306,
0.013418622,
0.005398336,
0.0034593279,
-0.029294467,
-0.04579491,
0.009149373,
0.015306152,
0.005401768,
0.012450835,
-0.03212233,
-0.0038711524,
0.024599664,
-0.0015168878,
-0.011483046,
0.0062322807,
-0.022581723,
-0.013878494,
0.0077011227,
0.022828817,
-0.002426334,
-0.020755967,
-0.00458155,
-0.014962966,
0.006884337,
-0.017845739,
0.0068362905,
-0.0183262,
0.008682638,
0.041457023,
0.0025292903,
-0.00421434,
0.00043370292,
-0.014619778,
-0.008984643,
0.0043138643,
0.022307172,
0.01592389,
-0.012814613,
0.04315923,
-0.018779207,
0.003967245,
0.0012457698,
-0.01801047,
-0.017530005,
0.015127695,
0.019355763,
-0.025423313,
-0.0063009183,
0.0134117585,
-0.014235408,
-0.019987227,
0.002561893,
-0.017447641,
-0.019122396,
-0.03912335,
0.010137752,
0.020000955,
0.0038402656,
-0.027262798,
-0.00083308714,
-0.016116075,
0.023281826,
-0.024160385,
0.017749647,
-0.039644994,
0.0078040785,
-0.0023113664,
-0.013686309,
-0.003239688,
-0.010556441,
-0.044175066,
-0.02193653,
0.010988857,
0.18779208,
-0.0070113163,
0.005048285,
0.013535306,
0.0040599057,
0.011716413,
0.03365981,
0.008078628,
-0.015278698,
0.018134017,
0.03769569,
-0.020028409,
0.00033482208,
0.010343664,
-0.0022049781,
-0.021758074,
-0.011174178,
-0.0029342512,
0.0013212711,
0.0012217467,
0.02112661,
0.010535849,
0.0044580027,
-0.008188449,
0.041155018,
0.026686242,
-0.01865566,
-0.015676795,
0.038546793,
0.022897456,
-0.020920696,
0.017090727,
0.0154297,
0.009430787,
-0.009588652,
-0.0053811767,
0.022828817,
0.010522122,
-0.009753383,
0.03047503,
0.015992528,
-0.024174111,
-0.010981993,
-0.0031487432,
-0.0028759094,
-0.011682095,
0.0007515801,
0.0021552162,
-0.01105063,
0.037064224,
-0.016802449,
-0.021373704,
0.033687264,
0.01636317,
-0.006771085,
-0.005793001,
0.021854166,
0.03042012,
0.013905948,
0.021140337,
-0.0124645615,
0.002506983,
-0.037009317,
0.0026116553,
-0.0065891957,
0.016390624,
0.008243359,
-0.0073579354,
-0.004375638,
0.0114212725,
-0.0017107886,
-0.012292968,
-0.013054844,
0.007632485,
-0.017900648,
-0.028141357,
0.028525727,
0.0052850842,
-0.0039020393,
0.024283933,
0.0042486587,
-0.006575468,
-0.02462712,
0.01510024,
-0.012924433,
-0.028360996,
0.00082965527,
0.00026361074,
-0.0033220528,
0.0026442579,
0.00782467,
-0.0029737176,
-0.004766871,
-0.01138009,
0.011181042,
0.008765003,
0.01570425,
-0.01947931,
-0.00668872,
-0.010494667,
-0.022348356,
0.0537294,
0.0048904186,
0.033357803,
-0.032012507,
-0.01914985,
-0.018037923,
-0.026466602,
-0.00749521,
0.02105797,
0.01359708,
-0.013562761,
0.020220594,
-0.029431742,
0.017186819,
0.025478223,
0.0033169051,
-0.013308803,
0.0019355762,
-0.0071657505,
-0.0032808704,
-0.008291405,
-0.01154482,
-0.004718825,
0.0043275915,
0.010089706,
0.0023130823,
-0.013192119,
0.014564868,
-0.0151139675,
0.00018982546,
-0.027180431,
0.010885901,
0.004207476,
-0.013013662,
-0.0010767501,
-0.017749647,
0.020097047,
-0.0043172957,
-0.01392654,
0.010474076,
-0.0041388385,
-0.010968265,
0.000026141219,
0.013068572,
0.002131193,
0.008703229,
0.022073805,
-0.026713697,
0.005175264,
-0.03714659,
-0.020371597,
-0.003833402,
-0.002479528,
0.022664087,
-0.00910819,
-0.033357803,
-0.017461369,
0.020412778,
0.015059058,
-0.03484037,
0.0036515126,
0.025533134,
0.006345533,
0.0038128106,
0.022389539,
-0.17428422,
0.004176589,
0.018079106,
-0.03456582,
0.0027146114,
0.00809922,
0.0017228001,
0.017447641,
-0.018394837,
0.021771802,
0.008181585,
0.005559634,
-0.030173026,
-0.016267076,
-0.020646147,
0.006517126,
-0.00441682,
0.04563018,
0.011798779,
0.018092833,
-0.0033632354,
-0.0048629637,
-0.0058650705,
-0.0019029734,
-0.009094463,
-0.00058127346,
-0.016335715,
0.0015220356,
0.0038917437,
-0.0034850668,
0.0062665995,
-0.0007262701,
0.0050620125,
-0.018532112,
0.0037956513,
0.024970306,
0.012951888,
0.008771867,
0.0029805815,
0.016349442,
-0.011750733,
0.026576422,
-0.005188992,
0.0105701685,
0.019630313,
-0.011586002,
0.02882773,
-0.003258563,
-0.0034129976,
-0.014798235,
-0.03349508,
0.0040942244,
0.02292491,
-0.00502083,
0.013995177,
0.0128420675,
0.024489844,
0.01854584,
0.014153044,
0.006012641,
-0.005985186,
-0.013514715,
0.011702687,
0.025354676,
-0.00998675,
-0.015525793,
0.008874823,
0.0009943851,
-0.009760247,
0.015937617,
-0.032534152,
-0.028580636,
0.00037707703,
-0.025505679,
0.044120155,
-0.003613762,
0.004989943,
0.0030904014,
-0.013068572,
-0.0029857294,
0.0005044853,
0.017076999,
0.0137069,
-0.00727557,
0.01348726,
0.022471903,
0.022801362,
0.019328307,
0.02204635,
-0.009334694,
0.01105063,
-0.029623926,
0.01176446,
-0.021497251,
-0.005566498,
0.017859466,
-0.00188753,
0.0039157667,
-0.0037132862,
0.006095006,
-0.0029170918,
0.02560177,
-0.01713191,
0.01821638,
0.007927626,
-0.0025018353,
-0.024640847,
0.006736766,
0.014729598,
-0.01871057,
-0.012190012,
-0.00765994,
0.027770715,
0.011579139,
0.0022736157,
0.03338526,
0.006880905,
-0.0064278976,
0.018422293,
-0.010027932,
0.051258452,
-0.0033598035,
-0.00090258254,
-0.013171528,
0.019795042,
-0.012382197,
-0.117068045,
-0.017475097,
0.012217467,
0.02669997,
-0.011023175,
0.025244856,
0.022677815,
0.038546793,
-0.016596537,
0.024283933,
-0.008188449,
-0.0038780163,
0.015361062,
-0.005171832,
0.016527899,
-0.015910162,
0.015086513,
-0.02937683,
-0.010625078,
0.047195114,
-0.001861791,
-0.0016164121,
0.008209039,
-0.019122396,
0.00012547785,
-0.021620799,
-0.029349376,
0.01548461,
0.010446621,
0.016404351,
0.008339451,
-0.02221108,
0.013404895,
0.012128239,
-0.0043344554,
-0.017008362,
-0.01116045,
-0.020179411,
0.042472858,
-0.0048561,
0.0067916764,
0.0012329003,
0.023762288,
0.005765546,
-0.014688415,
-0.008936597,
-0.010528985,
0.029019916,
0.030777035,
-0.020124502,
-0.009856339,
-0.014098133,
-0.0002940686,
-0.007955081,
0.020399053,
-0.023981927,
0.020769695,
0.008984643,
-0.03393436,
-0.007742305,
-0.0043550464,
0.03239688,
-0.007309889,
-0.0019681791,
-0.0019922021,
0.015566975,
-0.028498271,
0.0015203196,
0.0023422532,
0.0068054036,
-0.0011977236,
-0.01570425,
-0.016349442,
0.010144616,
-0.021730619,
-0.013844174,
-0.021812983,
-0.012972479,
-0.010590759,
0.00593714,
-0.020028409,
0.006115597,
-0.005539043,
-0.010103433,
0.019946044,
0.0002561035,
0.0003723582,
-0.0011316601,
0.009849475,
-0.025066398,
0.005635135,
0.0074540274,
0.018134017,
0.006898064,
0.004718825,
-0.022334628,
-0.021593343,
0.0017656985,
0.016074892,
0.00047059555,
-0.016637718,
-0.0055115875,
-0.04716766,
0.013253893,
0.011359499,
-0.017461369,
-0.014441321,
-0.013555897,
0.015512065,
-0.020646147,
-0.006180803,
-0.0064896713,
-0.03560911,
0.02844336,
0.008984643,
0.0034353046,
-0.02543704,
-0.0075432565,
0.026164599,
0.0062974864,
0.017516278,
0.015059058,
0.0014679836,
-0.012128239,
0.00024709484,
0.008106084,
-0.010515258,
-0.008909142,
-0.012965615,
0.017832011,
-0.014743325,
-0.016102348,
-0.0068431543,
-0.032369424,
0.00012354742,
0.01904003,
-0.042665042,
-0.043488692,
0.016871087,
0.013329394,
0.021744346,
0.029239556,
-0.025697863,
-0.028415907,
0.009128782,
-0.0096229715,
-0.017310366,
-0.005796433,
-0.022952365,
0.027180431,
0.0013530159,
-0.00071897736,
0.033055797,
-0.0021672277,
-0.007955081,
-0.014098133,
-0.03538947,
-0.008545363,
0.0052747885,
0.0018017332,
-0.014482503,
-0.013013662,
0.036515128,
-0.011448728,
0.030667216,
0.0131578,
-0.033302892,
-0.01154482,
-0.012025282,
0.0026888724,
-0.016486717,
0.0015340471,
-0.030173026,
-0.005556202,
0.020989334,
0.02204635,
0.01914985,
0.010021068,
-0.027427528,
-0.02932192,
-0.027825624,
0.016102348,
0.019396944,
0.023501465,
-0.02626069,
0.026192052,
0.016280804,
0.00007469686,
-0.03511492,
0.015470883,
0.011688959,
-0.0073922537,
0.009616108,
-0.0020282369,
0.007117704,
0.003833402,
0.010906491,
0.009870066,
-0.0066029234,
0.0014002041,
0.018806662,
-0.009046417,
-0.027015703,
0.017832011,
0.00809922,
-0.03063976,
-0.008291405,
0.018669387,
-0.046700925,
-0.016871087,
0.011668367,
-0.023350462,
0.012162557,
-0.012601837,
-0.020961879,
0.0079688085,
-0.0047634393,
-0.012869523,
-0.009753383,
0.022856273,
-0.020453962,
-0.012492017,
0.02314455,
0.009279784,
0.002017941,
0.010069115,
-0.027715804,
-0.007838397,
0.025313493,
-0.0043481826,
0.0052644927,
0.0049521923,
-0.019534219,
-0.0057175,
-0.023350462,
0.0067779487,
-0.0009403331,
-0.028251177,
0.0039466536,
-0.005171832,
-0.0030818218,
0.075061925,
0.014276591,
-0.010309346,
0.011640913,
-0.018587023,
0.009616108,
-0.0052679246,
-0.0064656483,
0.03047503,
-0.022252264,
0.03129868,
-0.018202653,
0.010940811,
-0.053345032,
-0.02210126,
0.009698472,
-0.006736766,
0.03426382,
-0.031271223,
-0.008188449,
0.0096229715,
0.016431807,
0.006338669,
0.0033254847,
-0.0029376831,
0.008559091,
0.025203673,
-0.019136123,
0.018339928,
-0.032561608,
-0.012910705,
0.0018103129,
-0.04302196,
0.00043005656,
0.009396467,
-0.01735155,
0.009959294,
-0.02730398,
-0.013933403,
0.027235342,
0.005401768,
0.030227935,
-0.0030183322,
-0.008160993,
0.010837854,
-0.008531636,
-0.009643562,
0.008765003,
-0.03379708
] |
OBJECTIVE Funnel plots (plots of effect estimates against sample size) may be useful to detect bias in meta-analyses that were later contradicted by large trials. We examined whether a simple test of asymmetry of funnel plots predicts discordance of results when meta-analyses are compared to large trials, and we assessed the prevalence of bias in published meta-analyses. DESIGN Medline search to identify pairs consisting of a meta-analysis and a single large trial (concordance of results was assumed if effects were in the same direction and the meta-analytic estimate was within 30% of the trial); analysis of funnel plots | [
-0.020738477,
-0.017524347,
0.03518206,
-0.020698467,
-0.004987904,
0.025499659,
-0.014843682,
0.019444823,
-0.0065449565,
-0.016777495,
-0.008355406,
0.034755286,
0.011262793,
0.017364306,
-0.0053146514,
0.016844178,
0.04211711,
0.018564604,
-0.01735097,
-0.015377147,
-0.03939644,
0.029527323,
-0.028567085,
-0.03382172,
-0.020698467,
0.021231933,
0.022352211,
-0.045798026,
-0.026619935,
-0.00042448027,
0.03096768,
0.014456919,
-0.018711308,
-0.013590037,
-0.012243036,
-0.0021688712,
0.007655232,
0.020711804,
0.029553996,
-0.021218596,
0.014857018,
0.013016562,
-0.025699707,
-0.036515724,
0.0048345323,
0.014870355,
0.039289746,
0.0062115407,
-0.027046708,
0.029153898,
0.018644623,
-0.02080516,
-0.038862973,
0.016350722,
-0.00044594394,
-0.01186961,
0.01194963,
-0.003392508,
-0.009115594,
-0.017324297,
-0.0064215926,
0.008128683,
-0.01917809,
-0.012816512,
-0.0017004218,
-0.020138329,
0.007468519,
0.018244525,
0.007828608,
0.0005705582,
0.020151665,
0.024286024,
-0.0122297,
0.01719093,
0.020258358,
-0.015817257,
-0.027020035,
-0.008642144,
0.01226971,
0.013116587,
0.02787358,
0.0033058198,
-0.015657216,
0.006755009,
-0.013723404,
-0.0048211957,
0.012236368,
0.033688355,
0.0062915604,
-0.005454686,
-0.021538675,
0.0048978813,
0.011329477,
-0.008502109,
-0.01413684,
0.004394423,
-0.011469511,
0.04016996,
0.01393679,
-0.012843185,
0.0005534706,
-0.007848613,
-0.015417157,
-0.008782178,
-0.014416909,
0.013790087,
0.00020327959,
-0.024952855,
-0.010235872,
-0.010262545,
-0.0072684693,
0.00853545,
-0.033048198,
-0.025219588,
-0.0048512034,
-0.010409248,
-0.0008339568,
0.0022805657,
-0.016257366,
-0.01326329,
0.010836021,
-0.012469759,
0.044037588,
-0.013516686,
0.025326282,
0.014230196,
-0.026579926,
-0.014736989,
-0.03038087,
-0.015177097,
0.0012361399,
0.026993362,
0.032648098,
-0.0023205755,
-0.012416413,
0.023659201,
0.007235128,
-0.010322561,
-0.01945816,
-0.013530022,
0.004641151,
0.0275535,
-0.0068683703,
-0.028540412,
-0.010382575,
0.016337385,
0.038542893,
0.005678075,
0.015963959,
-0.031341106,
-0.01004249,
-0.0170709,
0.0016837509,
0.030540908,
0.014270206,
-0.012636468,
0.0031024362,
0.01877799,
-0.014576949,
-0.016937533,
-0.025593014,
0.004737842,
0.019804912,
-0.004491114,
0.00528131,
0.012789839,
0.018697971,
-0.003430851,
0.003724257,
-0.023885924,
0.00038863806,
0.033261582,
-0.04161032,
0.0075352024,
0.0012002977,
-0.00239226,
0.00694839,
0.00444777,
-0.021151913,
-0.029233918,
0.0006384917,
0.0052879783,
0.028727125,
-0.0063749147,
-0.007928633,
0.0016129,
0.0139768,
-0.009022238,
-0.009335649,
-0.034408536,
0.006051501,
0.004681161,
-0.01548384,
0.006151526,
-0.6427194,
-0.019484833,
-0.009762421,
-0.043024004,
0.014323552,
0.0000038355865,
0.004204376,
0.0045944727,
-0.014176849,
0.020831833,
-0.0100958375,
0.03160784,
0.009108926,
-0.03168786,
-0.019791575,
-0.016630791,
-0.017817752,
-0.022698963,
0.019364802,
-0.008402084,
-0.017564356,
0.04630482,
-0.008642144,
0.0033625006,
0.008482104,
0.0019838254,
0.023272438,
0.007795267,
0.0045644655,
-0.0024272688,
-0.01600397,
0.014083493,
-0.0033558323,
0.010936046,
0.040996835,
-0.009122263,
0.009549035,
0.0153371375,
0.0048211957,
0.03696917,
-0.020671794,
0.0018037807,
0.03998325,
0.0017521012,
-0.02628652,
0.009182277,
0.021632032,
-0.0006835029,
0.020004962,
-0.020138329,
-0.004231049,
0.012829849,
-0.014830345,
0.015697226,
0.02160536,
0.007468519,
0.034408536,
-0.008642144,
-0.0069884,
0.02072514,
-0.023565846,
-0.007935301,
-0.032861482,
-0.013036567,
-0.0279536,
0.027926926,
0.0011994642,
0.008422089,
0.011229452,
0.0024039296,
0.008902208,
0.012816512,
-0.0025956437,
-0.009535698,
0.036809128,
0.016217355,
0.016884187,
-0.00038134458,
-0.03624899,
0.00032091292,
0.01889802,
0.033608336,
-0.011956299,
-0.0055713817,
0.015297127,
0.0025639692,
0.0032758124,
0.013269958,
0.0018988043,
0.015297127,
0.0011536195,
0.01861795,
0.004971233,
-0.02548632,
-0.035395447,
0.016510762,
-0.013923453,
0.03283481,
0.014536939,
-0.036542397,
-0.025566341,
-0.011882947,
0.008075336,
-0.017564356,
-0.0017637708,
0.0006605805,
0.005594721,
-0.007048415,
0.030994354,
-0.02950065,
0.02251225,
-0.015297127,
-0.009202282,
-0.02032504,
0.029820729,
-0.038089447,
-0.020938527,
0.0057514263,
-0.0059448075,
-0.010209199,
0.041103527,
0.0073751626,
0.015310464,
0.0008497941,
-0.001767105,
0.028247006,
-0.0012478095,
-0.023605855,
-0.0056680725,
-0.022325538,
-0.023459151,
0.007488524,
-0.004617812,
-0.0055080326,
-0.0028640437,
0.010662644,
0.030354194,
-0.011142763,
-0.015003721,
-0.0485187,
-0.031447798,
-0.027500154,
0.011482848,
-0.017497674,
-0.015817257,
-0.02012499,
-0.02934061,
0.0035708856,
0.016577445,
-0.0076619005,
-0.020311704,
-0.016897524,
-0.027766887,
0.0026773307,
0.0049112183,
-0.008828856,
-0.00020119574,
-0.008608802,
-0.014123503,
-0.04169034,
0.008135351,
0.016470753,
-0.02481949,
-0.01795112,
-0.0027523492,
-0.016817505,
-0.024566093,
-0.009809099,
0.011189442,
-0.03208796,
0.014176849,
-0.027660193,
-0.018231189,
0.049532287,
-0.023405805,
0.03176788,
-0.0024105979,
-0.0033641676,
-0.0026356536,
-0.0078619495,
0.01795112,
0.007155108,
-0.018244525,
-0.00044135947,
0.05323987,
0.0043344083,
0.014830345,
0.015657216,
-0.024312697,
0.022458903,
-0.022965696,
0.008602134,
-0.0041543636,
0.00615486,
-0.021525338,
0.0032124633,
0.0060681715,
0.011016065,
-0.012963215,
0.029447304,
0.010542614,
0.009815767,
0.0053579956,
-0.02255226,
0.013750077,
0.010749333,
0.024592767,
-0.018151168,
-0.0073684943,
-0.0068950434,
0.003517539,
-0.026459895,
-0.020098317,
-0.025326282,
-0.02604646,
0.009629055,
0.019884933,
0.02267229,
-0.0015770578,
0.008368743,
-0.0066483156,
-0.010635971,
0.026900005,
0.012569784,
0.019884933,
-0.016164009,
0.0020255023,
0.014363563,
0.017337633,
-0.013243285,
0.0073084794,
0.044117607,
0.000608901,
0.021845419,
0.041797034,
0.014670305,
0.01861795,
0.0071884496,
0.016564108,
0.0122297,
-0.005271307,
0.008768842,
-0.0004351079,
-0.0020538426,
0.017911108,
-0.017577693,
0.027766887,
0.014243533,
0.02243223,
-0.022445567,
0.008468767,
0.0017204267,
-0.01206966,
-0.0053546615,
0.029794056,
-0.021952111,
-0.0067483406,
-0.006778348,
0.032061286,
0.034408536,
0.040089943,
-0.01421686,
-0.010435922,
0.0012011313,
-0.006241548,
-0.013910117,
0.006471605,
0.0007564376,
-0.013043235,
-0.021725388,
-0.011489516,
-0.022925686,
0.017631039,
-0.0033858398,
0.009855778,
-0.005347993,
0.004477777,
0.00075810467,
0.017857762,
0.010749333,
-0.026099807,
-0.027820233,
0.044597726,
-0.011662893,
0.0023222426,
-0.025499659,
0.0142835425,
0.005367998,
-0.00407101,
-0.0070817564,
0.008315396,
-0.0030190821,
0.0007872786,
-0.009502357,
-0.005471357,
0.0016520764,
0.013990137,
-0.008242045,
0.021111904,
-0.021685379,
0.0108226845,
0.006765011,
-0.022765646,
-0.020511754,
0.012829849,
0.0069017117,
-0.027820233,
-0.043370757,
-0.003850955,
-0.009368991,
0.015017058,
-0.006348241,
-0.021578684,
0.015270454,
0.0112227835,
-0.00042552222,
0.0033758373,
0.0057747657,
0.03704919,
0.025899757,
-0.006448266,
-0.016977545,
-0.012676477,
0.026926678,
0.054146763,
0.03696917,
0.015430494,
0.0011061077,
-0.011836269,
0.017737733,
-0.02283233,
-0.02763352,
0.0103959115,
0.013296631,
-0.017897772,
-0.0020921857,
0.02990075,
0.01214968,
0.00060139917,
0.025512995,
0.0010452593,
-0.025046213,
-0.010829353,
0.0077885985,
0.00079686433,
-0.004927889,
0.031821225,
0.036595743,
0.0082887225,
-0.0072151227,
0.014923701,
0.025126232,
-0.014190186,
-0.0040576733,
-0.01242975,
0.015297127,
0.008808851,
0.034488555,
-0.01548384,
0.012456423,
0.014923701,
0.001973823,
0.013056572,
-0.0040243315,
0.011096085,
-0.0075352024,
0.002497286,
0.010982724,
0.012989888,
0.0044210963,
0.025139568,
0.0075285337,
0.018071149,
-0.007695242,
0.020658458,
-0.020991873,
-0.0038909651,
-0.002433937,
0.024699459,
-0.005848117,
-0.0025823072,
0.0125031015,
-0.00004370876,
-0.007175113,
-0.02140531,
-0.009955803,
0.01691086,
-0.0069017117,
0.009028906,
-0.025272936,
-0.0252596,
-0.014376899,
-0.0030524237,
-0.0040576733,
-0.022578934,
-0.030274175,
-0.019191427,
-0.015830593,
0.00865548,
0.0044344333,
0.024646113,
0.00034029273,
0.0136567205,
0.00016212354,
-0.014510266,
-0.00025923096,
-0.014230196,
-0.041903727,
-0.014670305,
0.007135103,
-0.013590037,
-0.011202779,
-0.01588394,
0.022285527,
0.007015073,
0.0020071645,
-0.009842441,
-0.0124030765,
-0.0005009576,
0.0020638453,
0.007935301,
0.022458903,
0.0049345572,
-0.025219588,
0.0054213447,
-0.030487562,
-0.00037759365,
-0.029313937,
-0.017137583,
-0.012663141,
-0.011982972,
0.009475684,
0.0024022625,
-0.011469511,
0.0047278395,
-0.020471744,
0.015497177,
0.007095093,
0.022658953,
-0.0021988787,
-0.012663141,
0.045691334,
0.0057680975,
-0.038089447,
-0.016123999,
0.01711091,
0.0102692135,
0.0018988043,
-0.02998077,
0.029047204,
-0.016217355,
-0.037609328,
-0.048251968,
0.0056347307,
-0.005434681,
0.015723899,
0.009915792,
-0.01389678,
-0.024672786,
-0.01123612,
-0.010542614,
-0.007261801,
-0.007361826,
-0.011382823,
-0.0037642668,
0.014616959,
-0.018818,
-0.011162769,
0.016510762,
-0.027100055,
-0.034568574,
0.020551763,
-0.025953103,
0.009782426,
0.017911108,
0.0069950684,
-0.03672911,
-0.0021355296,
0.004014329,
-0.03208796,
-0.0062348796,
0.020831833,
0.023245765,
0.0069884,
0.025379628,
0.01167623,
-0.00474451,
0.014323552,
-0.016564108,
0.012536443,
-0.009862446,
-0.010469263,
-0.0034208484,
0.011762917,
0.012583121,
-0.014176849,
0.027500154,
0.004604475,
0.026033124,
0.0049845697,
-0.010349234,
-0.014323552,
-0.002348916,
-0.015923949,
-0.007575212,
0.014230196,
0.013830096,
0.011382823,
-0.033128217,
0.0027106723,
0.0019721559,
0.018524595,
-0.018351218,
0.0025856413,
0.031981267,
-0.025633024,
0.012116338,
0.0027606848,
0.01731096,
-0.027846906,
-0.022538923,
-0.025539668,
-0.012049655,
0.009955803,
0.0022522253,
0.025366291,
0.03187457,
-0.010489268,
0.007075088,
0.001154453,
-0.015230444,
0.020418398,
0.0037709353,
-0.023365796,
-0.0004634483,
-0.015630543,
-0.0076819053,
-0.01564388,
0.01552385,
0.00932898,
-0.010082501,
0.0037976087,
-0.018204516,
-0.02588642,
-0.005347993,
-0.022018794,
0.042757273,
0.016324049,
0.019871594,
0.019951615,
-0.01735097,
-0.015923949,
0.014857018,
0.0003057008,
0.009495689,
0.017457664,
0.023325786,
-0.021418646,
-0.0014253535,
-0.006134855,
0.010782674,
-0.008808851,
-0.025392964,
0.0075285337,
0.0050412505,
-0.000770191,
-0.003347497,
0.003285815,
-0.016710812,
0.03771602,
-0.020645121,
-0.015990634,
0.00208385,
-0.034648594,
-0.0099691395,
0.037982754,
0.000556388,
0.04086347,
-0.02251225,
-0.011729576,
0.0022138825,
-0.0192181,
-0.040330004,
0.016524099,
0.0139768,
0.03422182,
-0.016764158,
0.008702158,
0.019551516,
0.013136592,
-0.006124852,
-0.016204018,
-0.03939644,
0.034061782,
0.000026959811,
0.009188945,
0.0031491143,
-0.013616711,
0.029367283,
-0.0022488912,
-0.0028807144,
-0.05396005,
-0.017004218,
0.0055413744,
0.037102535,
0.014323552,
0.00770191,
-0.00046719922,
-0.010695986,
-0.0033775044,
-0.02331245,
-0.019004714,
0.009022238,
-0.014550275,
-0.003159117,
0.013630047,
-0.019364802,
0.023645865,
0.010515941,
-0.01091604,
0.006574964,
-0.0056013893,
-0.028380372,
0.008642144,
0.0075352024,
-0.008522114,
-0.021151913,
0.013490013,
-0.017924445,
-0.0026473233,
-0.003680913,
-0.00770191,
-0.020618448,
-0.0136567205,
0.008115347,
0.030220829,
0.011789591,
0.009789094,
-0.0077819303,
0.022805655,
-0.011062744,
-0.020698467,
-0.024992865,
0.0066816574,
-0.029313937,
0.01584393,
0.02568637,
-0.00395098,
-0.004674493,
-0.0013019895,
0.012543111,
0.011162769,
-0.036435705,
-0.00043260728,
-0.012969883,
0.016564108,
-0.018364554,
0.0055247038,
-0.00074060034,
-0.006631645,
-0.007168445,
0.014310216,
0.009402332,
0.015897276,
-0.0033174895,
0.0053579956,
0.00074851897,
-0.0023022376,
-0.0059614787,
-0.022325538,
-0.0005426346,
0.020538427,
-0.0170709,
-0.01779108,
-0.010015817,
0.044330996,
0.032141306,
-0.0155371865,
-0.012009645,
-0.007281806,
-0.028006947,
-0.016364058,
-0.01091604,
0.035128713,
0.029153898,
0.026313193,
0.005174617,
0.016257366,
0.0059514763,
-0.018924695,
-0.016337385,
-0.018684635,
0.011202779,
0.0014720318,
0.020218348,
-0.00857546,
-0.032648098,
0.008075336,
0.022658953,
-0.012869859,
-0.012049655,
0.02353917,
-0.01369673,
-0.017857762,
-0.012769834,
-0.000114507566,
0.003144113,
-0.013963463,
-0.01131614,
-0.012363066,
-0.0027940264,
-0.022658953,
0.014456919,
0.006301563,
-0.0015345473,
-0.0073084794,
-0.007408504,
-0.024699459,
-0.034808632,
-0.016897524,
-0.013196606,
-0.01540382,
-0.00474451,
0.002765686,
0.031421125,
0.0031374448,
0.012383072,
-0.0005743091,
-0.016777495,
0.006091511,
0.019351466,
-0.0009752419,
0.02283233,
-0.0074551823,
-0.010215867,
-0.01091604,
0.0072151227,
-0.0034141801,
0.0010719325,
-0.03382172,
0.009862446,
-0.026606599,
0.02636654,
0.013636716,
-0.00074768544,
0.020298367,
0.0042810617,
-0.027366787,
-0.0047711832,
-0.017257614,
-0.0063315704,
-0.027340114,
0.04475777,
-0.025072886,
-0.008475435,
0.01052261,
0.006694994,
-0.012589789,
-0.047398422,
0.006785016,
0.18137832,
-0.014390236,
0.009088921,
0.020018298,
-0.011029402,
0.010155852,
0.022325538,
0.0046844953,
-0.00050970976,
0.005141275,
0.013276626,
0.015057067,
-0.017004218,
0.004484446,
0.034915328,
-0.021498665,
-0.025086222,
-0.035555486,
0.0016137336,
-0.016457414,
0.01965821,
0.0017237609,
-0.006258219,
-0.009962471,
0.0184179,
-0.005051253,
-0.0011161101,
-0.0021188587,
0.017937783,
0.01302323,
-0.018684635,
-0.02739346,
0.010615966,
0.017364306,
-0.008108677,
0.007988648,
-0.0046578217,
0.0019504838,
0.017644376,
0.003597559,
0.0015578864,
0.0140568195,
0.008102009,
0.006694994,
0.019831585,
0.02112524,
0.0073084794,
0.0018787993,
-0.0023455818,
0.0034775292,
-0.02787358,
0.0054780254,
0.019844921,
0.0109227095,
-0.0083354,
-0.0069817314,
0.038302835,
-0.012082997,
0.021085229,
-0.00051221036,
-0.0213653,
0.0015487175,
0.014150176,
0.0054846937,
-0.020418398,
-0.008268718,
-0.010129179,
-0.0028473728,
-0.01036257,
-0.022939023,
0.019364802,
-0.014403572,
-0.013803423,
0.00845543,
-0.010322561,
-0.02910055,
0.044304322,
0.02112524,
0.018431239,
0.019804912,
-0.017737733,
-0.020311704,
-0.032621425,
-0.012303052,
-0.013710067,
-0.028247006,
-0.0028407045,
0.008488772,
0.013710067,
0.016617455,
-0.0074151726,
0.0064582685,
-0.014643632,
-0.0045011165,
-0.0054413495,
0.014456919,
0.0023672539,
0.0042110444,
-0.031634513,
-0.00007804019,
-0.039023012,
0.06252217,
0.014990385,
0.0101958625,
0.0006176532,
-0.011796259,
-0.02572638,
0.030487562,
0.016630791,
0.0012244703,
0.013116587,
-0.056440666,
0.016257366,
-0.016524099,
0.0039209723,
0.012923205,
0.011589541,
-0.017564356,
-0.012916537,
0.0067516747,
-0.0142835425,
-0.010796011,
0.03598226,
0.03014081,
0.008342069,
0.009695738,
-0.022885676,
0.008868867,
0.014590286,
0.015577197,
0.009115594,
-0.041983746,
0.02481949,
0.0013745076,
0.012123006,
-0.021725388,
-0.0067083305,
-0.021512002,
0.0026739966,
-0.01576391,
-0.003804277,
0.0052546365,
-0.0016103995,
0.009602382,
-0.0076485635,
0.001080268,
0.003917638,
0.005244634,
-0.022378884,
-0.0032358025,
0.012589789,
0.009735748,
-0.002478948,
-0.012136343,
0.0040943488,
-0.024872836,
-0.006224877,
-0.046438184,
0.0076285587,
0.010842689,
-0.024392717,
0.00326581,
0.038169466,
0.0011286133,
0.018951368,
0.012103002,
-0.16804168,
0.009669065,
0.016617455,
0.008415421,
0.04097016,
0.005017911,
0.032328017,
0.005428013,
-0.008008653,
-0.0072484645,
0.002622317,
0.0022155496,
-0.015870603,
-0.018511258,
0.001185294,
0.013736741,
0.011809596,
0.017884435,
0.012416413,
0.023792569,
0.030647602,
-0.04105018,
0.02433937,
0.019778239,
0.008408752,
0.023525834,
-0.015150424,
0.028086966,
-0.00016306128,
-0.0018687969,
-0.014763662,
-0.010982724,
0.017524347,
-0.020258358,
0.0054446836,
0.0050679236,
-0.005157946,
-0.026513243,
-0.0056914114,
-0.0072684693,
0.0142835425,
0.013476675,
-0.01568389,
-0.0099691395,
0.012956547,
0.03248806,
0.014830345,
-0.024045965,
-0.0047211708,
-0.0083354,
-0.0013328305,
-0.016710812,
0.018457912,
-0.0027856908,
0.021178586,
0.007575212,
0.02008498,
0.023512498,
0.0046878294,
-0.022485577,
0.0013394989,
-0.043770857,
0.020591773,
-0.0011877946,
-0.012336393,
-0.017457664,
-0.024899509,
-0.0033741703,
-0.02008498,
0.004534458,
-0.009215619,
0.0060014883,
0.0102692135,
-0.017631039,
0.029073877,
0.0069350535,
-0.0227123,
0.0032408037,
0.021498665,
0.005964813,
-0.012636468,
0.0140568195,
-0.021965448,
-0.019204764,
0.013636716,
-0.016710812,
-0.008028658,
0.025953103,
-0.0005622228,
-0.003182456,
0.02676664,
-0.025619688,
0.0063915853,
-0.027166737,
-0.0004215629,
0.02425935,
0.010836021,
-0.013369983,
0.014696978,
-0.015670553,
-0.00395098,
-0.0065416223,
-0.02373922,
0.034968674,
0.012669809,
0.0041943737,
-0.0026873332,
0.015910612,
0.05686744,
-0.018217852,
-0.0007414339,
-0.0022922351,
-0.0046511535,
-0.0037142546,
-0.0048778765,
0.021378636,
0.014163513,
-0.0117495805,
0.0027956935,
-0.026686618,
0.060014885,
-0.009322312,
-0.001560387,
0.015257117,
0.003994324,
-0.016030643,
-0.12803176,
-0.024499409,
0.017724397,
0.0094423415,
0.010655976,
0.019844921,
-0.015230444,
0.018444575,
0.00048178615,
0.047745176,
-0.012196358,
-0.008688821,
-0.025206251,
-0.017524347,
0.015963959,
0.004384421,
0.009802431,
-0.04016996,
0.010809348,
0.04161032,
0.002205547,
0.008608802,
0.005684743,
-0.027340114,
0.01230972,
-0.010629303,
0.0042943982,
0.02263228,
-0.00010971471,
0.014150176,
0.019684883,
-0.008275386,
-0.004244386,
-0.011809596,
-0.016684137,
-0.027140064,
-0.019271446,
-0.02441939,
0.010309224,
-0.023392469,
-0.0043777525,
0.014470256,
0.028513739,
-0.0113494815,
-0.0056747408,
-0.020871844,
-0.031234413,
0.030167483,
-0.004701166,
0.0045644655,
-0.013736741,
-0.023125736,
-0.01917809,
0.0048378664,
0.014883691,
-0.008442094,
0.0016937534,
-0.0039809872,
-0.009982476,
0.016123999,
-0.022058804,
0.008488772,
-0.0128031755,
0.02974071,
0.007175113,
0.0048845448,
-0.0059414734,
-0.016937533,
0.0039209723,
-0.04478444,
-0.02787358,
0.028006947,
-0.0020088316,
0.017617702,
-0.029127223,
-0.008795515,
-0.036942497,
-0.000556388,
0.014350226,
-0.017671049,
0.006191536,
-0.020178339,
0.029553996,
-0.026619935,
0.01060263,
-0.0140568195,
-0.002663994,
-0.005388003,
-0.0048812106,
-0.028993858,
0.008475435,
0.018924695,
0.01885801,
-0.01743099,
-0.03259475,
0.0020571768,
0.013543359,
-0.016897524,
-0.0026873332,
-0.00084354257,
-0.029420631,
-0.0016145671,
-0.03632901,
0.02377923,
-0.004891213,
-0.006765011,
-0.003517539,
0.013843433,
0.02223218,
-0.022045467,
0.0009327313,
0.02112524,
-0.0076819053,
0.019604862,
-0.039076358,
-0.0065249517,
-0.014176849,
-0.026339866,
-0.0038742942,
0.012656473,
0.027900252,
0.029233918,
-0.017057564,
0.020378388,
0.01989827,
0.006051501,
-0.007515197,
-0.038169466,
0.00345419,
0.0043410766,
-0.028140312,
-0.014030146,
0.0056980797,
0.009248961,
-0.007855281,
-0.009995813,
-0.0008152022,
-0.034328513,
-0.013596705,
0.0028990523,
0.03363501,
0.00042614737,
-0.012709819,
-0.008155356,
0.015510513,
-0.018831337,
-0.0007918631,
0.023059053,
-0.028567085,
-0.010349234,
0.0043077352,
-0.002430603,
0.03315489,
0.0036709104,
-0.006384917,
-0.03200794,
-0.012209695,
0.0092422925,
0.018951368,
0.0275535,
-0.009515693,
-0.02259227,
0.028300352,
0.018124495,
0.010009149,
0.02628652,
-0.016550772,
-0.0019604862,
-0.01401681,
-0.0012461424,
0.002600645,
-0.010069164,
-0.02719341,
0.011589541,
-0.0020521756,
0.014470256,
0.019671546,
-0.0009235624,
-0.008368743,
0.012523106,
0.015163761,
0.0031041033,
0.011682898,
0.0017504342,
-0.011609546,
0.012936542,
0.026846658,
-0.0009327313,
-0.009422337,
0.00561806,
-0.003159117,
0.006028162,
-0.0092422925,
-0.0034408534,
-0.015043731,
0.021712052,
-0.0044044256,
0.025859747,
0.026900005,
0.01917809,
0.018151168,
-0.0071817813,
0.0036509056,
0.0048978813,
0.01186961,
-0.014670305,
0.005588053,
-0.024752805,
-0.005808107,
-0.041556973,
0.01711091,
0.031234413,
0.00653162,
-0.008128683,
-0.019404814,
-0.008782178,
0.00032841478,
0.003349164,
-0.004517787,
0.01091604,
0.008075336,
-0.010549283,
0.014977048,
0.0076885736,
0.009322312,
0.004724505,
0.02461944,
0.011629551,
0.03600893,
-0.030460889,
0.041423608,
-0.0024839493,
0.014536939,
-0.006281558,
-0.0027940264,
-0.0012478095,
0.008108677,
-0.0046511535,
0.0059848176,
-0.020458408,
0.022805655,
0.061668627,
-0.008528782,
0.0005317986,
-0.0131299235,
-0.023832578,
-0.0052746413,
0.00565807,
0.00024776979,
0.00573809,
-0.037182555,
0.0022005457,
0.017017554,
-0.00025923096,
-0.02377923,
-0.0060815085,
0.011509521,
0.00015628876,
0.006318234,
-0.028140312,
-0.016070653,
0.0051079337,
-0.026259847,
0.0065449565,
0.008075336,
0.012783171,
-0.016804168,
-0.010142515,
-0.0010585958,
-0.0052312976,
-0.008122015,
-0.0072751376,
0.02243223,
-0.016337385,
-0.008362074,
0.017737733,
-0.0064015877,
0.004331074,
-0.017297624,
0.0100958375,
0.013670057,
-0.006721667,
0.012636468,
-0.001872131,
-0.0127031505,
-0.01779108,
-0.0104826,
0.0062982286,
-0.0073751626,
-0.024886172
] |
Over the past years, plenty of evidence has emerged illustrating how metabolism supports many aspects of cellular function and how metabolic reprogramming can drive cell differentiation and fate. Here, we present a method to assess the metabolic configuration of single cells within their native tissue microenvironment via the visualization and quantification of multiple enzymatic activities measured at saturating substrate conditions combined with subsequent cell type identification. After careful validation of the approach and to demonstrate its potential, we assessed the intracellular metabolic configuration of different human immune cell populations in healthy and tumor colon tissue. Additionally, we analyzed the intercellular metabolic relationship between cancer cells and cancer-associated fibroblasts in | [
-0.00524155,
-0.0012249635,
0.0010491393,
-0.0344748,
-0.017595684,
-0.004869997,
-0.012639433,
0.008267052,
-0.023726307,
-0.0013568315,
0.018670533,
0.0017914157,
0.00996558,
-0.0032361594,
-0.038933437,
-0.007278456,
0.039543845,
0.012247976,
-0.024801156,
0.006585112,
-0.04700144,
0.008200703,
-0.011617663,
-0.010569353,
-0.011869788,
0.04336553,
0.008426289,
-0.043179754,
0.0070926794,
-0.021709304,
0.009866056,
-0.00838648,
-0.017900888,
-0.0053974693,
0.0056031505,
-0.024124399,
-0.0018080029,
-0.006346256,
0.0072386465,
-0.011120047,
0.004999377,
0.014490563,
-0.01097408,
0.0062036063,
-0.0042363666,
0.0005158614,
-0.004306033,
-0.006906903,
0.0055567063,
0.025584072,
0.017025085,
0.006425875,
-0.0113655375,
0.004226414,
-0.02717644,
-0.00587518,
-0.013229937,
0.018551106,
-0.011942772,
-0.023659958,
-0.013004351,
-0.016056392,
-0.029963087,
0.013628029,
0.0020916439,
-0.008320131,
-0.0038581789,
0.02362015,
0.010310593,
0.00057598995,
0.024920583,
0.017409908,
-0.009905865,
0.0065320325,
0.013010986,
-0.020806963,
-0.018219361,
0.006631556,
-0.0096802795,
0.017675303,
0.011139952,
-0.039490767,
-0.0047605215,
0.03757992,
0.0025577436,
-0.0037354336,
-0.016666802,
-0.0062633203,
0.034793276,
-0.0014397674,
0.012520006,
0.027547993,
0.024310175,
0.018113203,
-0.014556912,
0.007178933,
-0.009355172,
0.047399536,
0.0036160059,
-0.0073249,
-0.0076765483,
0.02086004,
-0.007782706,
-0.028529955,
-0.044772126,
-0.0017880984,
0.023739576,
-0.02196143,
0.025345216,
-0.014331326,
-0.029458838,
0.024004972,
0.00073854433,
-0.02250549,
0.0154061755,
0.019838272,
0.019519797,
-0.0034833085,
-0.019612685,
-0.004468587,
0.012685877,
0.012062199,
0.03609371,
-0.015631761,
0.033360142,
0.006741031,
-0.00015685255,
-0.009169395,
-0.016335057,
-0.002962471,
0.01987808,
-0.012188262,
0.0146630695,
0.027136631,
-0.016613722,
-0.011186396,
-0.0002193655,
0.002272444,
-0.00812772,
-0.014410945,
0.0115645835,
0.024164207,
-0.009049967,
-0.009972215,
-0.0137209175,
0.0040439554,
0.02868919,
0.0028745588,
0.0024349985,
-0.016945466,
-0.003433547,
-0.039543845,
0.016136011,
0.004385651,
0.009852787,
0.029750772,
0.018139744,
0.013044161,
-0.038031094,
-0.0069268076,
-0.0022293173,
-0.011876423,
0.0071391235,
0.005251502,
-0.011624298,
0.015525604,
0.00834667,
-0.009355172,
0.007265186,
-0.020329252,
0.0117769,
0.027468376,
-0.018949198,
0.017436447,
-0.012944638,
0.009587392,
-0.0137209175,
0.0051652486,
-0.022213556,
-0.03285589,
-0.011411982,
0.041560847,
0.013999582,
-0.014994813,
-0.016056392,
0.00003457391,
0.015087701,
0.012639433,
0.009494504,
-0.021656226,
-0.007928673,
0.023089359,
-0.008174164,
0.0024416333,
-0.6445912,
-0.0075438507,
0.012088739,
-0.02563715,
-0.000015356103,
0.032218944,
0.015777728,
0.0007522287,
-0.00706614,
0.0127854,
-0.004485174,
0.011730456,
0.005742483,
-0.028848428,
-0.017914157,
-0.034289025,
-0.020315982,
-0.018975737,
-0.009361806,
-0.008028196,
-0.03455442,
-0.00031598585,
-0.021284673,
0.0030039388,
-0.0036226409,
0.022903582,
0.025584072,
-0.0033190954,
-0.011810075,
0.030175403,
-0.036863357,
0.025040012,
-0.014238438,
-0.013389174,
0.04461289,
-0.0008218949,
-0.0075571206,
0.02354053,
-0.0037221638,
0.025796387,
0.005248185,
-0.009494504,
0.01283848,
0.017808,
-0.03463404,
0.018564375,
-0.0030885334,
0.0019622638,
0.0048500923,
-0.00886419,
-0.00430935,
0.00009262905,
-0.018922659,
0.0059382115,
0.024867505,
-0.0056694993,
0.020886581,
-0.016839309,
0.011179761,
0.016547374,
0.0014256684,
0.013581585,
-0.00040783736,
-0.020024048,
-0.024004972,
0.04450673,
0.0033423174,
0.01128592,
-0.02201451,
0.0027800119,
-0.0048136003,
0.01937383,
-0.004073812,
-0.0061040833,
0.014915195,
0.034156326,
0.019015547,
0.0073846136,
0.009368441,
0.010721955,
0.013813806,
-0.0009827906,
-0.026433336,
-0.012108644,
-0.00014762593,
-0.0064225574,
-0.030201944,
0.017662032,
0.0011254404,
0.0209662,
0.014570181,
0.00020910217,
-0.00535766,
-0.052043945,
-0.010310593,
0.02306282,
-0.025385024,
0.0135218715,
0.019134974,
-0.024442872,
-0.02935268,
-0.010582623,
0.030520417,
0.012334229,
0.02147045,
-0.0035363873,
-0.04341861,
-0.008267052,
0.042622425,
-0.025730038,
0.025809657,
-0.0146630695,
-0.022386063,
0.00081277196,
-0.001295459,
-0.024840966,
0.022319714,
0.011451791,
-0.017409908,
-0.016096203,
0.003609371,
-0.0026506318,
0.0024466095,
0.00733817,
0.02354053,
0.016626991,
0.00035558775,
-0.021921622,
-0.0025179344,
0.002396848,
-0.01932075,
0.0040903995,
0.025345216,
-0.020488488,
0.010403481,
0.005115487,
0.011956042,
-0.021735845,
-0.004757204,
-0.036252946,
-0.031236984,
-0.0313166,
-0.019201323,
-0.0214041,
-0.020568106,
0.01564503,
-0.024933854,
0.003450134,
0.021191785,
0.0076168342,
-0.014198628,
0.01618909,
-0.008486003,
0.013077335,
0.038429186,
-0.00095708045,
-0.018949198,
-0.02453576,
0.00056976976,
0.003032137,
-0.012115278,
0.013077335,
0.0052879937,
0.002955836,
-0.012619529,
0.0017167735,
-0.022677997,
-0.009739994,
-0.008831016,
-0.03980924,
-0.005944846,
-0.0043458417,
-0.010018659,
0.011053699,
-0.020660995,
0.019108435,
-0.028662652,
0.007736262,
-0.012466927,
-0.009454695,
0.015538873,
-0.009016792,
-0.018551106,
-0.0065784766,
0.04296744,
0.017476255,
0.023036279,
-0.009043332,
-0.0068471893,
0.043285914,
0.015512333,
0.012520006,
-0.007636739,
0.016388137,
-0.00055815873,
-0.014596721,
-0.022624917,
-0.014729419,
-0.009567487,
0.02460211,
0.011889692,
-0.022253364,
0.009793073,
-0.018219361,
0.0047605215,
-0.0014770887,
0.0042595887,
-0.0028065513,
0.012241341,
0.009985484,
0.0064889058,
0.00024051416,
-0.013488697,
-0.014901925,
-0.005506945,
0.00419324,
-0.0049960595,
-0.0104831,
-0.001831225,
-0.017953968,
0.009089776,
-0.01987808,
0.029538454,
-0.015087701,
-0.005666182,
0.0070727747,
-0.008764667,
0.008001657,
-0.008399749,
-0.00786896,
0.0027733769,
0.010954176,
0.018245902,
0.00087165646,
0.032218944,
0.023832465,
-0.002726933,
-0.020063857,
0.033360142,
0.01334273,
0.0074310577,
0.0021231594,
-0.0005768193,
-0.008492637,
0.0008073811,
-0.0017317019,
0.041746624,
0.020806963,
-0.017635493,
-0.0036259582,
-0.015525604,
0.013813806,
-0.01567157,
-0.002685465,
-0.00044121908,
-0.016892387,
0.0059747035,
0.0008509225,
0.03147584,
0.00940825,
0.011684012,
-0.00091395376,
-0.0056595467,
-0.009958944,
-0.018166283,
0.0073448047,
0.018060125,
-0.016348328,
-0.0044785393,
0.0074310577,
-0.024973663,
-0.017051624,
0.013037526,
-0.031263523,
0.0010549448,
0.013229937,
0.017038355,
0.0032378181,
0.013156953,
0.0071855676,
0.009202569,
-0.0029409076,
0.028476875,
0.020833502,
0.001292971,
-0.020767152,
-0.01940037,
-0.0092092035,
-0.008957079,
0.002556085,
0.023155708,
0.004823553,
-0.0127787655,
0.00043126676,
-0.03184739,
-0.008937174,
0.008532447,
-0.034713656,
0.03296205,
0.00039560432,
-0.0048301877,
-0.003944432,
-0.015326557,
-0.00616048,
0.04198548,
0.008220607,
-0.012659338,
-0.0017648763,
-0.0032958733,
-0.036359105,
-0.00021998752,
-0.00028384817,
-0.010244244,
-0.016348328,
0.0055334843,
0.0037951474,
-0.019612685,
0.0026489731,
0.047930323,
0.002066763,
-0.0146498,
-0.027123362,
0.010383576,
0.0056794514,
0.022306444,
0.021523528,
0.0018262488,
0.010124817,
-0.009441424,
-0.004286128,
-0.010874557,
-0.02514617,
0.01827244,
-0.03572216,
-0.013355999,
0.0010590916,
0.016547374,
-0.0140924705,
0.002755131,
0.011730456,
-0.013475427,
0.001985486,
-0.02141737,
0.015485794,
0.00014088738,
0.008963713,
0.04225087,
0.038323026,
0.033678617,
-0.00887746,
0.0076699136,
0.03139622,
-0.0135218715,
-0.0235538,
-0.0039776065,
0.04227741,
0.0010002072,
0.014185359,
-0.0025411565,
-0.009839517,
0.017555874,
0.0049728374,
0.007391249,
0.00561642,
-0.0033373411,
0.021842003,
0.016680071,
0.013694379,
0.003990876,
-0.0023188882,
-0.0015276795,
0.012062199,
0.012168357,
-0.02246568,
0.029432297,
-0.011723821,
-0.006372796,
-0.039968476,
-0.0027899642,
0.007941944,
0.0019805096,
-0.0071457583,
-0.01934729,
0.006764253,
-0.0054903575,
-0.0137209175,
0.024164207,
0.005059091,
-0.009063236,
0.005609785,
-0.005742483,
-0.031714693,
-0.02826456,
0.0028646064,
0.020130206,
-0.036518343,
-0.015313287,
0.01625544,
0.000099834106,
0.032749735,
0.0036524977,
-0.030440798,
-0.0020982786,
0.014968274,
-0.005553389,
0.0070263306,
-0.0009686915,
-0.04968193,
0.0024349985,
-0.011922867,
-0.004916441,
-0.028105322,
-0.004611237,
0.009686915,
-0.0020170014,
-0.015127511,
-0.0022392697,
0.01670661,
-0.012393943,
0.012559815,
-0.0048268703,
-0.0022243413,
-0.00057972205,
-0.026327176,
0.0045482055,
-0.032086246,
-0.007683183,
-0.019984238,
-0.015127511,
-0.02457557,
-0.011697281,
0.0074509624,
-0.009640471,
-0.0048202355,
0.010111547,
-0.008512543,
0.012672608,
0.007391249,
0.031183904,
0.009069872,
-0.031024667,
0.008605431,
0.010834748,
0.011352268,
0.008061371,
-0.0019821683,
0.019360559,
0.004315985,
-0.008532447,
0.0005801367,
-0.013528506,
-0.026884506,
-0.017900888,
-0.0034136423,
-0.013163588,
0.02249222,
-0.016401406,
-0.04286128,
-0.0038648136,
-0.012334229,
0.008771302,
0.016600452,
0.010967446,
-0.0035662444,
-0.02565042,
0.01669334,
-0.013840346,
-0.020634456,
0.018577645,
-0.043179754,
-0.010012024,
0.015472524,
-0.007377979,
0.028344179,
-0.0055467538,
0.0020750565,
-0.022677997,
0.00009351024,
-0.01101389,
-0.021762384,
-0.019188054,
-0.004239684,
0.06666721,
0.01829898,
0.018498026,
0.012082104,
0.026990663,
-0.013077335,
0.003904623,
-0.009169395,
-0.002750155,
0.014795767,
-0.012546545,
0.017064894,
0.013256476,
-0.0072054723,
-0.010164626,
-0.012354134,
0.007902134,
0.029273061,
-0.024349984,
-0.02245241,
0.004720712,
-0.0152336685,
-0.020767152,
0.033253983,
-0.015565412,
0.004574745,
-0.02776031,
-0.0272826,
0.023925353,
0.0110935075,
0.024296906,
0.024349984,
0.020461949,
-0.01782127,
0.024920583,
-0.02874227,
-0.0059382115,
-0.008870825,
-0.036942974,
-0.014809037,
-0.030228483,
0.02362015,
0.0032228897,
0.004004146,
0.012891559,
-0.010841383,
0.0040472727,
0.009892596,
-0.008751398,
-0.010124817,
0.0022011192,
-0.01940037,
-0.010542814,
-0.002819821,
-0.0007833297,
-0.010781669,
-0.0069865217,
-0.005699356,
-0.018391868,
0.006518763,
-0.018498026,
-0.012752227,
0.053105526,
0.029060744,
0.010635702,
-0.025517723,
0.034156326,
0.013694379,
0.0051619313,
-0.028344179,
0.0014654776,
-0.015578683,
-0.009799708,
0.046868745,
0.009414885,
0.0172374,
-0.01204893,
0.012221436,
-0.0018279075,
-0.010921001,
-0.014729419,
0.0054671355,
0.008207338,
-0.006999791,
-0.03147584,
-0.00092473545,
-0.016441215,
0.0020269537,
-0.021178516,
0.008598796,
-0.0043259375,
0.00034459872,
-0.026035242,
0.04442711,
0.0048136003,
-0.0009910841,
-0.0032444529,
-0.009182665,
-0.0077893413,
-0.018882848,
-0.023673227,
-0.005563341,
0.011770265,
0.018710343,
-0.0045913323,
0.016069664,
0.00733817,
0.015432715,
-0.009109681,
0.016414676,
-0.0023819194,
0.04137507,
0.008121084,
0.0027534724,
0.0016985275,
0.009879326,
0.02411113,
-0.0029127093,
-0.0049960595,
-0.024363255,
-0.038031094,
0.007032966,
0.028423797,
0.013999582,
-0.0069334423,
-0.013853615,
-0.011113413,
0.0027584485,
-0.025530992,
-0.020873312,
0.00051876414,
-0.012891559,
0.008353305,
0.014477293,
0.025491184,
0.022425871,
0.008253782,
0.011139952,
-0.032351643,
0.028556494,
-0.011975946,
0.04816918,
0.015499064,
0.0099125,
-0.02249222,
0.0061040833,
-0.016573913,
-0.022147207,
0.010118182,
-0.006886998,
-0.040950436,
-0.017808,
0.0057258955,
0.0050955825,
0.009746629,
-0.010463195,
0.00078872056,
0.015844077,
0.0059747035,
-0.0075571206,
-0.022863774,
-0.011126682,
-0.028609574,
0.005022599,
0.022704536,
-0.0139199635,
-0.000568111,
-0.0008940492,
-0.023659958,
-0.0030188672,
-0.009295457,
-0.012606259,
-0.033784773,
0.00993904,
-0.00886419,
0.01046983,
0.01257972,
-0.006512128,
-0.008466098,
-0.00012626994,
0.0068471893,
0.0056330073,
-0.031236984,
0.0009778144,
0.007278456,
0.015114241,
-0.041030057,
-0.014915195,
-0.016427945,
-0.016945466,
-0.01415882,
0.0073049953,
-0.040048096,
0.029432297,
0.0008384821,
-0.00010237402,
-0.042702045,
0.008194068,
-0.0471076,
-0.03811071,
0.01121957,
0.014689609,
-0.0034169597,
0.022054318,
-0.005450548,
0.007908769,
-0.013117144,
0.009434789,
0.00147543,
-0.018670533,
0.027256059,
-0.01569811,
0.0209662,
-0.00016131035,
-0.012075469,
-0.024230557,
0.029591534,
-0.027521454,
-0.007935308,
0.012659338,
-0.005205058,
0.034342103,
-0.008021561,
0.021881811,
0.018564375,
0.013946503,
0.048354957,
-0.003768608,
0.0017051625,
0.014875386,
-0.012612894,
-0.0026589255,
-0.011179761,
-0.0044553173,
0.01885631,
0.015936965,
-0.00047232004,
-0.02924652,
0.00032842622,
-0.021271404,
0.012884924,
0.0034899432,
-0.0052448674,
0.009627201,
0.009905865,
-0.020236364,
0.0013593197,
-0.008393114,
-0.02404478,
0.0038117347,
0.016932197,
-0.006260003,
-0.009195934,
0.00887746,
0.014941734,
-0.012201532,
-0.0050889477,
0.0038117347,
-0.014530372,
-0.010901096,
0.020607917,
0.0066912696,
-0.018139744,
-0.023699768,
0.009010158,
-0.026035242,
-0.014517102,
0.006206924,
0.021311212,
0.0003089363,
-0.009859421,
0.0045183487,
0.0078954995,
0.0053112158,
0.0029110506,
0.0026954173,
-0.024442872,
0.02093966,
0.18736883,
-0.029273061,
-0.006326352,
0.013827075,
0.005510262,
-0.01571138,
-0.011120047,
0.009222474,
0.0062500504,
-0.011451791,
0.013959773,
0.0026240924,
-0.002119842,
-0.011650837,
0.026353717,
0.013137049,
-0.017701842,
-0.0078954995,
-0.018245902,
-0.003881401,
-0.0017930744,
-0.011053699,
0.020581376,
-0.0076234695,
0.029166903,
-0.008054736,
-0.0051420266,
0.0050723604,
0.023938622,
0.010914367,
-0.0152071295,
0.025796387,
0.0033190954,
0.0008144307,
0.008665144,
0.015127511,
-0.0023769434,
0.00077918294,
0.020329252,
-0.016918927,
0.014304787,
-0.0015359732,
-0.0027352264,
-0.021709304,
0.01098735,
0.015392906,
-0.014596721,
0.0072983606,
0.0062301457,
-0.0140924705,
-0.030493878,
0.00274352,
0.007902134,
0.014450754,
0.016520834,
0.013355999,
0.013090605,
0.0067576184,
0.010118182,
0.025239058,
-0.032643575,
-0.0006668047,
-0.022797424,
0.009647106,
-0.023208786,
0.021669496,
-0.011783535,
-0.0058950847,
0.019148244,
-0.0037487033,
0.007125854,
-0.02042214,
-0.024960393,
-0.0018279075,
0.0038382742,
-0.009454695,
0.029326139,
0.015114241,
0.009401616,
0.017927427,
0.03200663,
0.00042276582,
-0.027415296,
0.008107815,
0.0013808829,
-0.034421723,
0.015565412,
0.0024068002,
-0.020329252,
0.008028196,
-0.0033058256,
0.00000635626,
-0.011969311,
-0.008983619,
0.0059149894,
0.006687952,
0.015538873,
0.0018212727,
-0.0021414054,
-0.02868919,
-0.03869458,
0.07733608,
0.013880155,
0.008651875,
-0.0076168342,
0.001960605,
-0.012393943,
0.005122122,
-0.008472733,
0.003914575,
0.019798461,
-0.031635076,
0.0059315767,
-0.003891353,
-0.022147207,
0.03670412,
-0.0020402235,
-0.04044619,
0.032086246,
-0.014994813,
-0.008837651,
-0.01994443,
0.002320547,
0.0136413,
-0.008147624,
0.0062301457,
-0.025305407,
0.010967446,
0.004017416,
-0.022903582,
-0.008446193,
0.01361476,
0.0017167735,
0.012115278,
0.007935308,
-0.013236572,
-0.004976155,
0.009222474,
-0.016547374,
0.015074432,
-0.019745383,
0.0012913122,
-0.002114866,
0.023036279,
-0.008738128,
0.01411901,
0.01415882,
0.023354754,
-0.005427326,
-0.036465265,
-0.003292556,
-0.014636531,
-0.016295249,
-0.0010939247,
0.020130206,
-0.0015459255,
-0.005818784,
-0.025371755,
0.002925979,
0.002731909,
-0.037739158,
0.026380256,
0.006631556,
-0.03033464,
-0.011073603,
-0.005709308,
-0.16656186,
0.005619738,
0.024257096,
-0.02148372,
0.0162289,
0.014384405,
0.0128782885,
0.004133526,
-0.0152071295,
0.010781669,
0.029166903,
-0.01774165,
-0.05541446,
-0.00061828725,
0.024230557,
0.017662032,
0.003426912,
0.038323026,
0.0049529327,
-0.00044329246,
0.022359522,
-0.025504453,
0.01782127,
0.001057433,
0.011717186,
0.009812977,
0.013773996,
0.02044868,
-0.009514408,
-0.0101513555,
-0.010503004,
-0.0006576818,
0.011577854,
0.001283848,
0.009129586,
0.0054339613,
-0.007258551,
0.01097408,
0.00007469416,
0.005483723,
0.02306282,
0.02765415,
-0.008107815,
-0.002043541,
-0.017582415,
0.0107684,
0.0024631966,
0.0024399746,
0.03142276,
0.0041832877,
0.022943392,
0.0031100968,
-0.007265186,
0.020116936,
0.026804887,
0.004869997,
0.009461329,
0.014052661,
0.006070909,
-0.026857967,
-0.009806342,
-0.006694587,
0.013117144,
0.01098735,
-0.005878498,
-0.021324482,
0.012188262,
0.0033655395,
-0.013004351,
0.007013061,
-0.022956662,
-0.006100766,
-0.0015600246,
-0.009116316,
0.02672527,
-0.0075770253,
0.00731163,
-0.0023653323,
-0.0015757824,
0.019917889,
-0.016852578,
-0.0007899646,
-0.018126473,
-0.027494915,
-0.0051652486,
0.0018677168,
0.013336095,
0.0052780416,
-0.024243826,
-0.005788927,
0.032112785,
-0.035536382,
-0.0051320745,
-0.02565042,
0.044745583,
0.02202778,
0.00041426488,
0.0016471073,
-0.0026755126,
-0.019825,
0.0045482055,
-0.0235538,
-0.02147045,
0.018949198,
0.013229937,
-0.006057639,
-0.02304955,
-0.0055235317,
0.03519137,
-0.013077335,
-0.02874227,
-0.009567487,
0.012586354,
0.03251088,
-0.014795767,
0.043710545,
0.0061969715,
-0.017635493,
-0.004743934,
-0.029963087,
0.074151345,
0.009773168,
-0.0068140146,
0.033333603,
0.018325519,
-0.026221018,
-0.13566989,
-0.019851541,
-0.012354134,
0.011418616,
0.013773996,
0.02403151,
-0.005195106,
0.0045249835,
-0.008996888,
0.021921622,
-0.032218944,
-0.0008948785,
-0.0073846136,
-0.03086543,
-0.018551106,
-0.0029807168,
0.006372796,
0.0027899642,
-0.022293175,
0.028981127,
0.012745592,
-0.0062334635,
-0.01360149,
-0.014875386,
0.022094127,
0.026287368,
-0.028078783,
0.033121288,
0.01628198,
0.010582623,
0.0039013054,
0.004674268,
0.018073395,
-0.005447231,
0.022266634,
0.018139744,
0.013747457,
-0.018060125,
0.007915404,
-0.0037088941,
-0.018060125,
0.005029234,
0.009885961,
0.0011088531,
-0.0026008703,
0.008937174,
-0.028874967,
0.00074642326,
0.000113311195,
-0.035987552,
-0.019970968,
-0.014556912,
-0.02452249,
-0.028981127,
0.0014414262,
-0.0397827,
0.0036989418,
0.011166492,
-0.009116316,
-0.0069334423,
0.0016014925,
-0.00811445,
0.00082148024,
0.0130507955,
0.018935928,
-0.02511963,
-0.0071391235,
-0.03089197,
0.011438522,
-0.0257035,
0.009766533,
-0.007762802,
-0.012652704,
0.00020806548,
-0.017423177,
-0.0034136423,
0.008519177,
-0.010078372,
-0.013203397,
-0.0106224315,
-0.014039392,
-0.020024048,
0.016374867,
-0.0013278039,
0.025212519,
-0.005944846,
0.012234706,
0.0056694993,
0.011418616,
0.006425875,
0.007212107,
0.049841166,
0.020475218,
-0.019254401,
-0.010967446,
-0.0036226409,
0.013906694,
0.0054339613,
0.004156748,
0.011577854,
-0.025544262,
-0.00785569,
-0.041667003,
0.012732321,
-0.010980715,
-0.0046377764,
0.013163588,
-0.006034417,
-0.017383367,
-0.01046983,
0.014994813,
0.046603348,
-0.012241341,
0.002396848,
-0.00865851,
-0.01202239,
-0.028397257,
-0.013256476,
0.01618909,
-0.012374039,
0.008220607,
0.033307064,
0.0006883681,
0.00731163,
0.00366245,
0.013409079,
-0.0024748077,
-0.006754301,
-0.019586146,
0.034979053,
-0.0029773994,
-0.045249835,
0.011916232,
-0.009282188,
-0.0077229924,
0.00786896,
-0.016918927,
0.002932614,
-0.0008019903,
0.022173746,
0.027030474,
0.031263523,
0.0065917466,
-0.024628649,
0.011484966,
0.0036491803,
-0.0021696035,
0.012858384,
-0.027547993,
0.004216462,
-0.00017603148,
-0.0077694366,
0.044851743,
0.010463195,
-0.008731493,
-0.03397055,
-0.0045183487,
0.00627659,
0.02826456,
0.0025809656,
-0.010648971,
-0.011438522,
0.0261414,
0.020302711,
0.021151975,
-0.002066763,
0.00864524,
-0.0073514394,
-0.018551106,
0.0024250462,
0.00044412183,
-0.0386415,
-0.017502796,
0.0015185566,
0.009779803,
-0.008844286,
0.019679034,
-0.007258551,
-0.019201323,
0.027680691,
0.015923696,
0.036306027,
0.01336927,
-0.011066969,
-0.0060211476,
0.022160476,
0.02362015,
0.0005826248,
0.0013725894,
0.042171255,
-0.0119361365,
-0.008558987,
0.008671779,
0.0041103037,
0.0064325095,
-0.0057458,
0.005858593,
0.019506527,
0.022704536,
0.02876881,
0.006260003,
0.03606717,
-0.001574953,
0.0076765483,
0.024177479,
-0.029511916,
-0.013336095,
0.020302711,
-0.019148244,
-0.024840966,
-0.035616,
0.015963504,
-0.014716148,
0.01725067,
0.0030935097,
-0.008446193,
-0.02868919,
0.018524567,
-0.005865228,
0.02036906,
-0.021085627,
0.0019224545,
0.021271404,
0.0106224315,
0.012148453,
-0.006223511,
0.014503833,
0.027627612,
0.016003314,
-0.008612066,
0.035934474,
0.004916441,
0.03036118,
0.013973043,
-0.02257184,
-0.02099274,
-0.028450336,
-0.022598378,
-0.00024155085,
-0.00043416952,
-0.0061737495,
0.08428943,
0.0019257719,
-0.018630724,
0.0021944842,
-0.022266634,
0.014503833,
0.023713037,
0.0047737914,
-0.012095374,
-0.008459464,
0.022094127,
-0.0130507955,
0.01100062,
-0.05082313,
0.007218742,
0.031581998,
-0.012168357,
0.010078372,
-0.0031432712,
-0.002338793,
-0.0058619105,
-0.02348745,
0.0073846136,
0.011431887,
-0.025769848,
-0.002371967,
0.04960231,
-0.0019290894,
-0.0018643994,
-0.02874227,
0.004992742,
-0.007849055,
-0.04806302,
0.0038216868,
0.016520834,
-0.01885631,
-0.0039842413,
-0.024310175,
0.022638187,
0.022545299,
0.001124611,
0.012898194,
-0.025862735,
-0.0063761133,
-0.019081896,
-0.012055565,
-0.015260208,
-0.019161513,
-0.013501967
] |
OBJECTIVE To assess the antihypertensive efficacy of olmesartan medoxomil and ramipril on 24-h ambulatory blood pressure (ABP) in elderly hypertensive patients by pooled data analysis of two studies with identical designs (one Italian, one European). METHODS After a 2-week placebo wash-out 1453 elderly hypertensive patients (65-89 years; sitting office DBP 90-109 mmHg and/or sitting office SBP 140-179 mmHg) were randomized to a 12-week double-blind treatment with olmesartan medoxomil 10 mg or | [
-0.016419336,
0.0028251696,
0.010125037,
-0.03666941,
-0.014266198,
0.027185032,
-0.0030778002,
-0.0004520106,
-0.034476645,
-0.001287095,
-0.0130707435,
0.004699259,
-0.0032495228,
0.001327549,
-0.01632687,
0.011379935,
0.027977599,
0.00204251,
0.009715545,
0.007278403,
-0.0053068935,
0.014186941,
-0.0009601613,
0.017106228,
-0.012033802,
-0.02134646,
0.00745673,
-0.02726429,
0.007628453,
-0.03009111,
0.010052386,
0.0018063913,
-0.0069283526,
-0.0043624183,
-0.00089163735,
0.0006286869,
-0.0043921396,
0.0028284718,
0.01470211,
-0.010904395,
0.02063315,
-0.010726067,
0.0018988574,
-0.009761778,
0.010501507,
-0.011241236,
0.024939427,
-0.018202612,
-0.013566097,
0.01445113,
0.0010055688,
0.0044978154,
0.009405123,
0.0075425915,
0.019880211,
-0.012819764,
0.009550427,
0.035982523,
-0.0024850264,
-0.022588147,
0.009741964,
0.0014802831,
-0.009814615,
0.006713699,
-0.035903264,
0.0024602588,
-0.01148561,
-0.0017849259,
0.01921974,
0.013830286,
0.05085635,
0.017594978,
-0.017172275,
0.016141938,
0.030223204,
-0.019985886,
-0.011677147,
-0.014715319,
0.0019847187,
0.014319036,
0.019933049,
-0.023433551,
-0.0072321696,
-0.003095963,
0.029959016,
0.015085183,
0.0002586161,
0.0013902938,
-0.012060221,
-0.008222878,
0.022693822,
0.011353516,
0.012733903,
-0.0031999873,
-0.017925214,
0.0114327725,
-0.007529382,
0.03717137,
-0.028373882,
-0.010831743,
-0.0076812906,
-0.01871778,
-0.027951181,
-0.0037779005,
-0.03500502,
0.012753717,
-0.018123355,
-0.007773757,
0.034450226,
0.012575389,
0.0091871675,
0.043696836,
0.0069217477,
-0.030460974,
-0.025084732,
-0.007793571,
0.008493671,
-0.01968207,
0.0015843075,
-0.0052804747,
-0.008282321,
0.013539678,
0.014649272,
-0.014847414,
0.004193998,
-0.006347137,
-0.014741737,
-0.03223104,
-0.010527926,
0.012588599,
-0.026260372,
0.041081365,
0.0042963712,
-0.021135109,
-0.027739828,
0.01826866,
-0.0034212456,
-0.011518634,
-0.028611653,
-0.029879758,
0.019576393,
0.02203335,
-0.016736364,
-0.012390457,
-0.031464893,
0.01197436,
0.012053616,
0.019999096,
-0.003398129,
-0.005145078,
-0.017555349,
-0.045836765,
0.0039529256,
0.0097881965,
-0.013724611,
-0.006198531,
-0.00018193942,
0.02558669,
-0.03154415,
0.017740281,
-0.011928126,
0.011089327,
0.00426665,
0.008374787,
0.0044185584,
0.004682747,
-0.01067323,
-0.02015761,
-0.0055281515,
0.015798492,
-0.010818534,
0.033261377,
-0.018083727,
0.013698192,
0.030170366,
0.007952085,
0.01338777,
-0.01492667,
-0.0007306473,
-0.028083274,
-0.03270658,
0.010666625,
0.017410045,
0.017238323,
-0.008539905,
0.038545154,
0.015204068,
-0.00027306395,
0.007674686,
-0.037092116,
0.0156664,
0.031861175,
-0.014781366,
-0.007654872,
-0.63320786,
-0.029668408,
-0.008051155,
-0.016868457,
0.012522551,
0.019800954,
0.028849423,
0.013935962,
0.002940752,
0.015745655,
0.004837958,
0.014900251,
0.016789202,
-0.012357433,
-0.01704018,
-0.013592516,
0.0045803743,
-0.007113285,
0.03104219,
-0.026194325,
-0.0132292565,
0.014556806,
-0.009081491,
0.013407584,
0.006307509,
0.0015983426,
0.021399297,
-0.009213586,
-0.024120443,
0.035691913,
0.009206981,
0.034714416,
0.006158903,
0.018096937,
0.0450442,
-0.028056856,
0.0010196038,
0.014068056,
0.006769839,
0.022852335,
0.0012169199,
-0.005402662,
0.010257132,
-0.020989804,
0.0032693371,
0.007007609,
0.01078551,
-0.0051417756,
0.002032603,
0.0036788296,
0.008387996,
-0.0064693247,
-0.014873832,
0.0030381717,
0.010930814,
0.019827373,
0.002729401,
0.00089411414,
0.0036160848,
-0.016934505,
-0.022614565,
0.006703792,
-0.01896876,
-0.024965847,
0.011842265,
0.014847414,
0.0009981385,
0.022839125,
0.011571472,
-0.012865997,
0.00037605633,
0.013988799,
-0.0025675853,
-0.009240005,
0.032363135,
-0.021518182,
0.014081266,
0.015362581,
-0.014781366,
0.014160522,
0.003304012,
0.016974134,
-0.008711628,
0.018730989,
0.04264008,
0.009557032,
-0.021491762,
-0.002059022,
-0.008480462,
-0.016591059,
0.017885584,
0.017251533,
0.003332082,
-0.03368408,
-0.003487293,
0.022456052,
-0.021689905,
0.011465796,
0.015943797,
-0.025494223,
-0.024833752,
0.007417102,
0.0070274235,
0.007146308,
-0.00090154447,
0.017621396,
-0.0201444,
-0.0037415747,
0.03437097,
-0.037541237,
0.013698192,
0.010924209,
-0.0321782,
-0.0007711012,
0.011776218,
-0.024331793,
0.0061787167,
-0.021201156,
0.008526695,
-0.021438925,
0.016155148,
-0.018559266,
0.017661024,
0.012344224,
-0.0031933826,
0.00817004,
-0.00076779886,
0.0022571634,
-0.010164666,
-0.053445406,
0.011062908,
-0.0063240207,
0.012013988,
-0.0067170016,
0.029932598,
0.0049700527,
0.007318031,
-0.014319036,
0.013724611,
-0.014543597,
-0.015375791,
-0.0060565295,
-0.01682883,
-0.0069547715,
0.01066002,
-0.034212455,
0.011796032,
-0.008216273,
-0.021822,
-0.0017436465,
0.0008156831,
-0.027039729,
-0.0068358863,
0.012839578,
-0.011109141,
-0.027290707,
-0.001931881,
-0.020289704,
-0.041847512,
0.0082889255,
0.021755952,
0.0049667503,
-0.029113611,
-0.00538615,
-0.0126216225,
-0.04401386,
-0.0028251696,
0.019312205,
-0.013684982,
-0.044991363,
0.00852009,
-0.007813386,
-0.0073312405,
0.010924209,
-0.04668217,
0.025745204,
-0.017845957,
0.0014092824,
0.015983425,
0.003057986,
0.01315,
0.02372416,
-0.0023925602,
0.005614013,
0.038016774,
-0.024490306,
0.009497589,
0.0099401055,
-0.006565093,
0.03460874,
0.0010204294,
0.044674333,
-0.02627358,
0.016379708,
-0.009200376,
-0.008553114,
0.029457057,
-0.002407421,
0.035850428,
0.024992265,
0.049139127,
0.003378315,
0.026484933,
0.0035335259,
0.009002235,
0.006581605,
0.023103315,
-0.0067434204,
0.046576492,
0.01727795,
-0.011313887,
0.0030530323,
-0.027052939,
-0.020051934,
-0.0010039177,
0.015058764,
0.008236088,
0.008064365,
-0.009457961,
0.001478632,
0.00840781,
0.010105223,
0.018757408,
-0.005465407,
-0.012013988,
-0.008196459,
0.043247715,
0.025798041,
0.019048017,
-0.014358664,
-0.011366725,
-0.007747338,
0.015798492,
0.014728528,
0.016194776,
0.007185937,
0.009854244,
-0.019074434,
-0.001208664,
0.0052507534,
0.010527926,
0.010395831,
0.03439739,
-0.018797036,
0.0003607829,
0.00023322922,
0.033525564,
0.039760422,
0.02368453,
-0.0034212456,
-0.017436463,
0.013486841,
-0.00622495,
-0.007965294,
-0.0026567492,
0.010726067,
-0.0014819343,
0.018995179,
0.020461427,
0.02199372,
0.037039276,
0.04530839,
0.0012672809,
-0.0060400176,
0.029140031,
-0.008487067,
0.007773757,
-0.016247615,
0.0018245543,
-0.020435007,
-0.013202838,
-0.012080035,
-0.0062216474,
-0.026022602,
0.006135786,
-0.004174184,
-0.008625766,
0.0064065796,
0.033604823,
0.013803868,
-0.013684982,
-0.042560823,
0.015455048,
-0.00021857499,
0.0012689321,
-0.0004030944,
-0.0013803868,
-0.004524234,
-0.002509794,
0.03157057,
0.003305663,
-0.004682747,
0.0039331117,
0.0058385734,
-0.010818534,
-0.030038273,
0.04150407,
-0.008222878,
-0.0026963775,
-0.021069061,
0.0045176293,
-0.008903164,
0.0005481919,
-0.04480643,
0.014332245,
0.007668081,
-0.0021184643,
-0.028955098,
-0.013295304,
0.019140482,
-0.004355814,
-0.018638523,
0.0048412606,
0.02155781,
0.018387545,
0.016168358,
-0.037012856,
0.004137858,
0.024199698,
-0.022574937,
-0.019576393,
-0.024807334,
0.0003527334,
-0.012872602,
0.045836765,
0.021386087,
0.012542366,
0.016366499,
0.0037878077,
0.016802412,
-0.008506881,
-0.01126105,
0.006152298,
0.036114614,
-0.01803089,
-0.0044416753,
0.008790884,
0.0031719173,
-0.0058682947,
-0.00029556127,
0.028294627,
-0.03009111,
0.021861628,
-0.0106798345,
-0.02083129,
0.025718784,
0.02413365,
0.052467905,
0.018981969,
-0.0180441,
0.018863084,
0.014979508,
0.024371421,
-0.010349598,
-0.0002662528,
0.012007384,
0.001295351,
0.007397288,
-0.008308739,
-0.0126348315,
0.004989867,
0.0035500377,
0.01684204,
-0.0061688097,
0.024754494,
0.025441386,
-0.004804935,
0.010950628,
-0.004332697,
-0.02015761,
-0.0053465217,
0.016908087,
-0.0021234178,
-0.024780914,
0.010131642,
-0.0019021598,
-0.014966299,
-0.011465796,
-0.0009964873,
0.006934957,
-0.0060235057,
-0.010580763,
-0.02180879,
-0.013632145,
-0.018638523,
-0.020963386,
0.035480563,
-0.02180879,
-0.032548066,
-0.02081808,
-0.027211452,
-0.0062414617,
-0.0055611753,
0.024027975,
-0.0032098945,
0.0056437342,
-0.023261828,
0.04718413,
0.022693822,
0.005485221,
0.007925666,
-0.008269111,
-0.011076118,
0.02940422,
-0.01631366,
-0.0038076218,
0.024860172,
-0.02747564,
0.009741964,
-0.001259025,
-0.01634008,
-0.008916373,
-0.0013143396,
0.020223657,
0.016577851,
-0.02818895,
0.030540232,
-0.013764239,
-0.0039166,
-0.0078332,
0.027039729,
0.0011112443,
-0.02133325,
-0.01327549,
0.000038312544,
-0.04057941,
-0.01018448,
-0.02204656,
0.005320103,
0.0068821195,
-0.014794576,
0.004094927,
-0.0144247115,
-0.010904395,
0.014556806,
-0.010911,
-0.013856705,
-0.0060763434,
0.015322953,
0.006875515,
-0.009827825,
0.037831843,
0.013698192,
0.004415256,
-0.016709944,
0.009055072,
0.024463888,
-0.0059475517,
-0.03452948,
0.0026947262,
0.017145857,
-0.019827373,
-0.012000779,
-0.0015843075,
0.0068557006,
0.047210548,
0.005465407,
-0.033578403,
-0.028056856,
0.008764465,
-0.0050361,
0.0033073141,
0.0043260925,
0.0055545704,
0.01207343,
0.006895329,
-0.018387545,
0.016789202,
0.0071397037,
-0.014292616,
0.019048017,
-0.015058764,
-0.021161526,
-0.00022187736,
0.0058385734,
-0.0057824333,
-0.0005259009,
0.021822,
-0.031702664,
-0.011842265,
-0.024846962,
-0.026498143,
0.012951858,
0.015296535,
0.015138021,
0.008229483,
-0.018757408,
0.015270116,
0.0063834633,
0.00804455,
-0.0015000973,
0.0051781014,
-0.013282094,
0.020421797,
0.018334705,
0.013777449,
-0.008011526,
-0.030672325,
0.00028255823,
0.0035929685,
0.0039859493,
-0.016564641,
-0.01587775,
-0.029219287,
0.0070010046,
-0.019087644,
0.00050443556,
0.006290997,
-0.03157057,
-0.024437468,
-0.00049122615,
0.008949397,
0.014371874,
-0.011776218,
-0.0007508742,
-0.040843595,
0.035163537,
0.004705864,
0.018836666,
-0.0069943997,
-0.0020771849,
-0.002749215,
0.014319036,
0.020580312,
-0.0038043195,
0.000083849,
-0.0037613888,
-0.012733903,
-0.0000033184854,
0.01184887,
-0.027105777,
0.014887041,
-0.0040354845,
0.0017750189,
0.0160891,
-0.0038043195,
-0.019061226,
-0.0084474385,
-0.014781366,
0.03672225,
-0.007278403,
0.019298995,
-0.031200703,
-0.011776218,
-0.0047487947,
-0.033208538,
0.027898343,
-0.0003100091,
0.022099398,
0.03341989,
-0.01089779,
0.0064726267,
0.0039033904,
0.0022901872,
0.0017898795,
0.032046106,
0.0313328,
-0.024701657,
-0.02015761,
-0.010263737,
0.016643897,
-0.012377247,
-0.032785837,
0.035929684,
-0.00009881282,
-0.01540221,
-0.0030067994,
0.0132292565,
-0.042745758,
0.019470718,
-0.009992943,
-0.030698745,
0.023776997,
0.0076416624,
-0.013064139,
0.0033651055,
0.004405349,
-0.002674912,
0.017119437,
-0.046999197,
0.0012829672,
0.0017931819,
-0.007919061,
0.0056734555,
-0.0055743847,
0.037620492,
-0.015547514,
-0.0022934894,
-0.008249297,
0.013044325,
0.014517177,
-0.008784279,
-0.013671773,
0.034027524,
0.009590055,
-0.024979055,
0.029959016,
-0.016155148,
-0.0007058796,
0.002509794,
-0.016670316,
-0.024503516,
-0.0021646975,
0.00269968,
0.024212908,
0.021293622,
-0.031596985,
0.016406128,
-0.03291793,
-0.010977047,
-0.0014026777,
-0.0012639785,
-0.022799497,
-0.035480563,
-0.009002235,
-0.0013539678,
-0.016683526,
0.043062784,
0.009444752,
0.0070538423,
0.04079076,
-0.015111602,
-0.014371874,
0.018149775,
0.0034971999,
0.0027046334,
-0.022878755,
0.02180879,
-0.028823003,
-0.030011853,
0.0031636616,
-0.0050592166,
-0.028717328,
-0.026868006,
-0.010290156,
-0.011512029,
0.007397288,
-0.011551658,
0.0321782,
-0.01040904,
0.017951632,
-0.006948167,
-0.008539905,
-0.0056569437,
-0.0160891,
0.0015372488,
0.0010377668,
-0.011538448,
0.010541135,
-0.006426394,
0.012060221,
0.011155374,
-0.023156153,
-0.0043921396,
-0.011228026,
0.037831843,
-0.038122453,
-0.008698418,
-0.032865092,
0.00900884,
0.0017089716,
0.022799497,
-0.012740508,
-0.012040406,
-0.02202014,
0.0041246484,
0.0065948144,
-0.018281868,
-0.007826595,
0.007978504,
-0.0024751192,
0.0022191864,
-0.0135264695,
-0.021135109,
-0.01422657,
0.04166258,
0.011763008,
0.017766701,
-0.0052705677,
-0.028849423,
-0.048742842,
-0.014464339,
-0.010712858,
0.025375338,
-0.007463335,
-0.0033304307,
0.037858263,
0.011056303,
-0.0063174157,
-0.012238548,
-0.026696283,
0.0014076312,
-0.00031145388,
-0.033050027,
0.029959016,
-0.015428629,
-0.05328689,
-0.001150047,
0.017951632,
-0.021914465,
-0.004755399,
0.030857258,
0.011650728,
-0.0046365145,
-0.0044185584,
-0.0033733614,
0.007938875,
-0.04380251,
-0.00081650866,
-0.021848418,
0.0059904824,
0.017357208,
0.021135109,
-0.016617479,
-0.040447313,
0.008936188,
0.0121857105,
-0.011379935,
-0.029959016,
-0.029140031,
-0.009240005,
-0.029140031,
0.002765727,
-0.0072321696,
-0.017238323,
0.007853013,
0.0039694374,
0.0034740835,
-0.01941788,
0.003949623,
-0.0016206335,
-0.027422803,
0.007925666,
-0.00055108144,
-0.005065821,
-0.013202838,
0.0075756153,
-0.0215446,
0.0042633475,
-0.0103892265,
0.0055281515,
0.009048468,
0.006363649,
0.04575751,
-0.003087707,
0.0041312533,
-0.00033044245,
0.013328328,
0.016591059,
-0.009827825,
0.0025774925,
0.007912456,
-0.014820995,
-0.0018625314,
-0.0058220616,
0.000041511707,
-0.011769613,
-0.027819086,
0.0019170203,
0.035612658,
0.19697921,
-0.0075425915,
-0.00023611878,
0.012608413,
-0.0102307135,
0.030487394,
0.010957233,
0.035427723,
0.005164892,
0.036193874,
-0.0050427048,
-0.016908087,
-0.008189854,
-0.0010864766,
-0.0018113448,
-0.025296083,
0.0021102084,
-0.0072123557,
0.022720242,
-0.010613787,
-0.0057890383,
-0.008843722,
0.015626771,
0.001786577,
0.033525564,
0.012826369,
-0.00852009,
-0.0007950433,
0.03669583,
0.017674234,
-0.0072123557,
-0.018427173,
0.009510798,
0.008995631,
-0.0074765445,
-0.014847414,
-0.015389001,
-0.014358664,
-0.0067896536,
-0.010547739,
-0.01943109,
0.0055446634,
-0.016921297,
-0.013282094,
0.017753491,
0.01681562,
0.0032841975,
-0.02818895,
0.000652629,
-0.0013473631,
-0.034186035,
0.021306831,
0.010290156,
-0.00137791,
0.011214817,
-0.026894424,
0.022693822,
0.0016379709,
-0.024543144,
0.0022373493,
0.003989252,
-0.0040420895,
-0.012152687,
0.0075888247,
-0.008434229,
0.018215822,
-0.009629684,
-0.012390457,
-0.0015983426,
0.007489754,
0.015349372,
-0.0337105,
-0.0075491965,
0.0050625186,
-0.009741964,
-0.029562732,
0.022139026,
0.045598995,
0.011003465,
0.020527475,
0.013790658,
-0.007205751,
-0.014292616,
0.010144852,
-0.020197237,
-0.04150407,
-0.004837958,
0.002737657,
-0.028585233,
0.0046530263,
-0.0016792504,
-0.028796585,
-0.017159065,
-0.014266198,
0.033182118,
-0.009451356,
-0.021108689,
0.017713862,
-0.030962933,
-0.02298443,
0.004065206,
0.06277127,
0.009292843,
0.0013713052,
-0.009768383,
-0.03410678,
0.009741964,
0.019351833,
-0.0046133976,
0.009055072,
0.02509794,
-0.022416424,
0.004260045,
-0.018823456,
-0.011868685,
0.02180879,
0.019999096,
-0.007767152,
-0.0076812906,
-0.024622401,
0.0034839904,
-0.022812707,
-0.011452586,
0.031438474,
0.0004107311,
-0.008189854,
-0.010052386,
0.0075690104,
-0.0055545704,
-0.023116525,
-0.007608639,
-0.0076482673,
0.008579533,
-0.0029622174,
-0.00083384605,
0.016445756,
-0.024939427,
0.0038340406,
-0.015838122,
-0.0038802738,
0.016947715,
-0.014028428,
-0.0041345553,
0.010613787,
0.027819086,
-0.0044846055,
0.009200376,
0.011181793,
-0.008117203,
-0.0012565482,
-0.0029457058,
-0.010640206,
-0.00006264165,
-0.008705023,
0.029879758,
-0.018136565,
-0.0051054494,
-0.002197721,
-0.0038076218,
-0.0060235057,
-0.044119537,
-0.01078551,
0.0020738824,
-0.013427398,
-0.0016891574,
0.010164666,
-0.16612194,
0.010442064,
0.014332245,
-0.023829835,
0.00569327,
0.005878202,
0.043644,
-0.0026798656,
-0.008203064,
-0.00485447,
0.014979508,
-0.0010625345,
-0.014662481,
-0.020025514,
0.01338777,
0.0069547715,
0.00520452,
0.0075888247,
0.029509895,
0.0021102084,
0.019814163,
-0.011584681,
0.012317806,
-0.021069061,
0.023816625,
0.014319036,
0.0017832747,
0.03645806,
0.004078415,
0.0051417756,
-0.027766248,
0.019127272,
0.03622029,
0.011300678,
-0.0057626194,
0.012773531,
0.0020771849,
0.015560723,
-0.016934505,
0.026577398,
0.0023578855,
0.0021102084,
-0.010257132,
0.011683752,
-0.024477096,
0.039866097,
0.03056665,
-0.02632642,
0.0047917254,
-0.011829056,
0.0048974007,
-0.022865545,
0.012238548,
-0.021003013,
0.009755174,
0.00426665,
-0.019919839,
0.012218734,
0.0049238196,
-0.0007905026,
-0.019827373,
0.018110145,
0.034661576,
-0.014002009,
0.0036689227,
-0.011340306,
-0.0008577882,
0.0004937029,
-0.014015218,
0.027079357,
-0.0360882,
0.0006773967,
-0.004999774,
-0.008275716,
0.029140031,
0.022403214,
-0.0035302236,
-0.0055446634,
0.02869091,
0.010316575,
-0.0029308451,
-0.0022125817,
-0.02061994,
0.0016247614,
-0.00028255823,
0.020184029,
-0.020923756,
0.006941562,
0.0047289804,
-0.019708488,
0.0115780765,
-0.025084732,
0.021108689,
-0.0015075277,
-0.0025395153,
0.008638975,
-0.01040904,
0.008790884,
-0.0031091725,
-0.033842593,
0.013883124,
-0.012615018,
-0.0079983175,
0.008559719,
0.013935962,
-0.0050790305,
0.0012895719,
0.0050228904,
0.019761326,
-0.017489301,
-0.0012936997,
0.0033799661,
-0.0087446505,
0.019087644,
-0.0003453031,
0.008381391,
0.0018196007,
-0.019298995,
-0.0156135615,
-0.02842672,
0.050988447,
0.010977047,
-0.0016008193,
0.035665493,
-0.012773531,
-0.012641436,
-0.11328418,
-0.02132004,
0.0160891,
-0.00073394965,
0.0044813035,
0.024107233,
-0.00083632284,
0.0225221,
0.015005927,
0.027845506,
-0.020461427,
-0.011716776,
-0.0027161916,
-0.024820542,
0.05196595,
0.018189402,
0.011564867,
-0.023856252,
-0.02414686,
0.039998192,
-0.0063141137,
-0.012033802,
0.0058121546,
-0.0013721308,
-0.011029884,
-0.017423255,
-0.013817077,
0.014530387,
0.0050790305,
0.021438925,
0.026960472,
-0.0011574774,
-0.003057986,
0.02747564,
-0.0044482797,
-0.009570241,
-0.01631366,
-0.010666625,
0.019100854,
-0.007159518,
0.017832747,
0.0156664,
0.00549843,
-0.04163616,
-0.0064396034,
0.00083178206,
-0.005475314,
-0.02083129,
0.00065593136,
-0.017925214,
0.008989026,
-0.018334705,
-0.0051516825,
0.012965068,
0.021253994,
0.001812996,
0.00204251,
0.00794548,
-0.03392185,
-0.03223104,
-0.0021960698,
-0.010329784,
-0.0130707435,
0.0047950274,
-0.0057395026,
-0.025045102,
-0.0019896722,
-0.037065696,
0.0087380465,
-0.0019351833,
-0.027792668,
0.006697187,
-0.0028284718,
0.00302166,
-0.020170819,
0.015772074,
-0.015058764,
-0.019312205,
0.007555801,
0.010706253,
-0.023592064,
-0.009319262,
0.013031115,
0.004534141,
-0.0056998744,
0.009002235,
-0.004055299,
0.00028771817,
0.031068608,
-0.03394827,
-0.0051681944,
0.021452134,
-0.015032345,
-0.012852788,
0.012971672,
0.016300453,
-0.0020094865,
-0.044383727,
0.015389001,
-0.0074501256,
-0.014173732,
-0.014675691,
-0.067209646,
0.01278674,
0.04060583,
0.004415256,
0.014847414,
-0.0042171143,
0.021504972,
0.008242692,
-0.006327323,
-0.021069061,
-0.04768609,
0.000050644798,
-0.01682883,
-0.0012763623,
-0.036642995,
0.00864558,
0.020646358,
0.009570241,
0.02513757,
-0.0058022477,
-0.017713862,
0.0106798345,
-0.0050294953,
0.02845314,
0.0057956427,
0.004762004,
-0.018744199,
0.011419563,
-0.009530613,
0.0076416624,
-0.015692817,
-0.029721245,
0.0014505619,
0.013328328,
-0.030672325,
-0.010778905,
-0.0031388937,
0.021069061,
0.005481919,
-0.0010245574,
-0.027607735,
-0.0215446,
0.035110697,
-0.03820171,
0.0054885233,
-0.0018773921,
-0.022310749,
0.01684204,
-0.01291223,
-0.05426439,
0.033842593,
0.014834204,
-0.0056173154,
-0.031385634,
-0.029906178,
0.014503968,
0.0035401306,
0.014649272,
0.0015314698,
-0.014966299,
0.029007936,
-0.008216273,
-0.013552888,
-0.033182118,
-0.0034014315,
-0.0060565295,
0.005263963,
-0.0024024674,
0.0046629333,
-0.009576846,
-0.009827825,
-0.0055710822,
0.0061060647,
0.017951632,
0.0076614767,
0.01422657,
-0.00817004,
0.014173732,
-0.010778905,
0.008467252,
0.016432546,
-0.01516444,
-0.020950176,
0.007436916,
-0.021267202,
0.0066443495,
-0.0024883288,
0.02390909,
-0.015428629,
-0.0021432322,
-0.0067500253,
-0.00046563285,
-0.028928678,
-0.005237544,
-0.0005622269,
0.03606178,
-0.0009114515,
-0.01470211,
0.012423481,
0.03629955,
0.006175414,
0.0062315543,
-0.00598718,
-0.03957549,
-0.0016198079,
-0.014054847,
-0.003982647,
-0.011796032,
-0.009220191,
0.016023053,
0.029483475,
0.027819086,
0.009524008,
0.014332245,
0.017410045,
0.014041637,
-0.01029676,
-0.013684982,
-0.003579759,
0.027766248,
-0.0030365207,
0.014847414,
0.01018448,
0.005310196,
0.0042171143,
0.0025411665,
0.034978602,
0.011214817,
0.028638072,
0.0042633475,
0.010686439,
-0.019008387,
-0.008718232,
0.0053333123,
-0.01707981,
-0.022614565,
-0.008348368,
0.037303466,
0.0116111,
0.084012054,
0.01267446,
-0.01989342,
0.0013325025,
0.014411502,
0.030857258,
-0.008625766,
0.020738825,
-0.018532848,
-0.017647816,
-0.0071991463,
-0.0052507534,
0.02887584,
-0.02869091,
-0.020355752,
0.004669538,
-0.0039958563,
0.014411502,
-0.016049473,
-0.018546058,
0.013843495,
-0.01491346,
0.0018939038,
-0.00052424974,
-0.025058312,
-0.010719462,
0.017449673,
-0.011095932,
-0.023116525,
-0.03817529,
-0.0029869853,
0.030989353,
-0.014820995,
-0.016987342,
0.046497237,
-0.0201444,
0.007767152,
-0.017013762,
0.001172338,
-0.03199327,
0.0004375628,
0.03006469,
-0.01421336,
-0.018863084,
0.007767152,
-0.040024612,
0.0014249686,
-0.014900251,
-0.019312205
] |
WAVE2 belongs to a family of proteins that mediates actin reorganization by relaying signals from Rac to the Arp2/3 complex, resulting in lamellipodia protrusion. WAVE2 displays Arp2/3-dependent actin nucleation activity in vitro, and does not bind directly to Rac. Instead, it forms macromolecular complexes that have been reported to exert both positive and negative modes of regulation. How these complexes are assembled, localized and activated in vivo remains to be established. Here we use tandem mass spectrometry to identify an Abi1-based complex containing WAVE2, Nap1 ( | [
-0.027612172,
-0.009882823,
-0.0024707057,
-0.01703701,
-0.012971205,
0.0114982845,
-0.007194912,
0.008348813,
0.00023417403,
-0.01064304,
0.019331235,
0.004642755,
0.016059587,
0.017675048,
0.0039605955,
0.0073849666,
0.0021805335,
-0.011837667,
-0.004927836,
0.020077879,
-0.011471134,
0.015340096,
-0.009767433,
-0.01857102,
-0.019792797,
0.008335238,
0.0018360602,
-0.024259072,
-0.0035499425,
-0.037522145,
0.020634465,
-0.020688767,
0.006397363,
0.013527793,
0.006455058,
-0.014932836,
0.02658045,
-0.009088667,
0.009387325,
-0.007493569,
0.019901399,
-0.00019228148,
-0.000626161,
0.007710774,
-0.011953057,
-0.000587132,
0.0166569,
0.0022942268,
-0.00594259,
0.018503143,
-0.0073238774,
-0.00653651,
-0.00809767,
-0.011796941,
-0.009149756,
-0.03461703,
0.0022993174,
0.028915402,
0.008708559,
-0.010744855,
-0.007921191,
0.012339953,
-0.022535007,
0.0047886893,
0.011179265,
0.028535293,
0.017634323,
0.003634788,
-0.0062548225,
-0.012509645,
0.05419262,
0.00571181,
-0.029186908,
-0.0020312052,
0.017566446,
-0.035594452,
-0.0377665,
-0.016684052,
-0.014593454,
0.010934909,
-0.015503,
-0.023756785,
0.0034667938,
0.0138536,
0.01934481,
-0.0045680907,
-0.0019463595,
0.0094008995,
-0.012923691,
-0.0041574375,
0.014267647,
0.05356816,
-0.0014118318,
0.0011708701,
-0.010262932,
0.009407687,
-0.012896541,
0.007934767,
-0.014349098,
-0.028996853,
-0.0025165223,
0.0034718846,
-0.015869534,
-0.01790583,
-0.010514075,
-0.021218203,
-0.017308515,
0.005735567,
0.0277072,
0.0013159562,
-0.029186908,
0.034725633,
0.027137037,
-0.03635467,
0.00798228,
-0.0049380176,
0.024191195,
-0.002876268,
0.024082594,
-0.009509502,
0.0066451123,
0.04509717,
0.012387467,
-0.013045869,
0.038852528,
0.00559642,
-0.01929051,
-0.0056642964,
-0.010079665,
-0.013290225,
0.009984638,
0.012964417,
0.019181907,
0.008477779,
-0.0013159562,
0.006611174,
0.005535331,
-0.005246856,
0.0038044795,
-0.021041725,
0.01307302,
0.03282509,
-0.019181907,
-0.004754751,
-0.002250107,
0.027856529,
0.021353956,
0.0010716007,
-0.0042354953,
0.024625605,
-0.005613389,
-0.019914974,
0.0074528432,
-0.022426406,
-0.0024350705,
0.03586596,
-0.012048084,
0.02064804,
-0.033911116,
-0.014769933,
-0.0048260214,
0.040997423,
-0.011878393,
0.011348956,
0.03651757,
0.027585022,
0.00997785,
-0.0053317016,
-0.020960273,
-0.004262646,
-0.018978277,
-0.0069912826,
-0.007805801,
0.012855815,
-0.005148435,
-0.012265289,
0.005131466,
0.0094008995,
-0.017865103,
-0.012129536,
0.007174549,
-0.01341919,
-0.00026599114,
-0.004086167,
-0.004011503,
-0.018190911,
0.024191195,
-0.007690411,
-0.0005688902,
-0.015122891,
0.010873821,
0.019439839,
-0.0076021715,
0.0022585916,
-0.60209197,
-0.028073734,
0.026091738,
-0.012855815,
-0.019684194,
0.029784221,
0.003285224,
0.024883537,
0.010133966,
0.017484995,
-0.026824804,
0.027042009,
0.00160528,
-0.011824092,
-0.018991854,
-0.029512715,
-0.010364746,
-0.027883679,
0.039857097,
-0.014661331,
-0.037657898,
0.017322091,
-0.011179265,
0.0082062725,
0.002738818,
0.001280321,
0.016941981,
-0.02172049,
-0.025725204,
0.019534865,
-0.02276579,
0.031033149,
-0.0061054938,
0.011864818,
0.0399114,
-0.016751928,
-0.009835309,
0.024462702,
0.02148971,
-0.002032902,
-0.011138539,
-0.010948485,
-0.0013957112,
-0.014281222,
-0.0057219914,
-0.0012888056,
0.012855815,
0.016874105,
-0.0042524645,
-0.022915117,
0.010907758,
-0.0059968913,
-0.04031866,
-0.002640397,
0.026105314,
-0.0015738871,
0.016032437,
-0.020810945,
0.0048463843,
0.025372246,
0.013174835,
0.008355601,
0.0037671474,
-0.03822806,
-0.012231351,
-0.0046291794,
-0.01463418,
0.015448699,
0.010113603,
0.027218489,
-0.009333023,
0.01307302,
0.012129536,
-0.004398399,
0.008661046,
0.05354101,
-0.012244926,
0.00488711,
-0.019439839,
0.020105029,
-0.0059358026,
-0.0028694803,
-0.02645827,
-0.006655294,
0.01096206,
0.031168902,
-0.025399398,
0.040182907,
0.0073849666,
-0.009136181,
0.0058272,
0.011613674,
-0.021340381,
-0.05104315,
-0.018788224,
0.032553583,
0.0073510283,
0.014213346,
-0.009787796,
-0.016059587,
-0.010928121,
0.0011233566,
0.03279794,
-0.026811229,
0.017009858,
-0.015611602,
-0.026946982,
0.0106973415,
0.036626175,
-0.018937552,
0.0005587087,
-0.012563946,
-0.01622249,
-0.02108245,
-0.00763611,
-0.022833664,
0.006648506,
0.009713132,
0.009183695,
-0.028182335,
0.01599171,
-0.0122042,
0.023091596,
0.008885038,
0.00012832906,
0.00997785,
0.02501929,
-0.016724776,
-0.015665904,
-0.030761644,
0.017050585,
-0.00786689,
0.008898613,
-0.019141182,
0.0073578157,
0.019684194,
0.014566303,
0.03624607,
0.0061122817,
-0.033150896,
-0.019304086,
-0.0006397363,
0.0018021219,
-0.029567016,
-0.004473063,
-0.04126893,
-0.033340953,
0.004357673,
-0.0013744998,
0.008090883,
0.0039062942,
0.016141038,
-0.0045443336,
0.008925764,
0.039314087,
-0.009115818,
-0.018150184,
-0.017430693,
0.00038456297,
-0.010541225,
-0.0166026,
-0.0029051155,
-0.00559642,
0.012747212,
-0.0040250784,
-0.018516717,
-0.0027473026,
-0.0049380176,
-0.020200055,
-0.03097885,
0.0062955483,
0.0020634464,
-0.030788794,
0.034209773,
0.0029119032,
0.0399657,
0.00394702,
0.019195482,
-0.011118175,
0.0054640607,
-0.0021432014,
0.010887396,
0.0026913045,
-0.014824234,
0.030082878,
0.015978135,
0.025847383,
-0.0056812656,
-0.0074256924,
0.025983136,
-0.03369391,
0.02039011,
-0.00067664415,
0.0037841166,
-0.010690553,
-0.011810516,
0.028236637,
0.0042762216,
0.011477921,
0.04118748,
0.005131466,
-0.006977707,
-0.023906114,
0.0013371677,
-0.0050398326,
-0.031739067,
-0.0007152489,
-0.03627322,
0.043250926,
0.0033887357,
-0.009421263,
-0.009611317,
-0.0075275074,
-0.0044968203,
0.0045239707,
0.004262646,
-0.0131001705,
0.00051755854,
0.0067028073,
-0.0008739103,
0.006478815,
0.0027625747,
0.01749857,
-0.018978277,
-0.014973562,
-0.01639897,
-0.0035838808,
0.03013718,
0.0030289902,
-0.010595527,
-0.0009613014,
0.020077879,
0.020091454,
0.03678908,
-0.009041154,
0.0020821125,
0.012163474,
-0.012034508,
0.025562301,
-0.009299085,
-0.0028830557,
0.0047309943,
0.011681551,
-0.0023604063,
0.024462702,
-0.008151972,
0.006977707,
0.022005571,
0.0041947695,
0.0032597703,
-0.009984638,
0.024489852,
-0.020254357,
0.011674764,
-0.002014236,
-0.015842382,
0.020553013,
0.014172619,
0.049386963,
0.020539438,
0.016711202,
0.020118603,
-0.005148435,
-0.0086135315,
0.0018716953,
-0.02151686,
0.029947124,
-0.017987281,
-0.021815516,
-0.0051552225,
-0.015245069,
-0.001016451,
0.026281793,
-0.039721347,
0.02374321,
-0.011667975,
0.013222348,
0.0036687264,
0.0023383466,
0.024109744,
-0.019073306,
-0.029892825,
0.00344134,
0.016439695,
-0.016806228,
-0.0069980705,
-0.033856813,
0.016100314,
-0.009156544,
0.014145469,
0.011505072,
0.0072356383,
-0.0013804389,
0.0051348596,
-0.028182335,
0.006865711,
0.028671047,
-0.0054674544,
0.016331093,
-0.0254537,
0.014349098,
0.0012175352,
0.008179122,
-0.0032954055,
0.034291223,
-0.013364889,
0.017797226,
-0.0052875816,
-0.017607171,
-0.016154613,
-0.00028592988,
0.0014160741,
0.029186908,
-0.011722277,
0.0075071445,
-0.0143083725,
0.015801657,
-0.032254927,
0.030490138,
0.0038248424,
0.0030561408,
-0.021163901,
0.012774363,
0.0067638964,
-0.004951593,
0.0443641,
0.014335523,
0.018150184,
-0.008355601,
-0.008382752,
-0.029214058,
-0.017919404,
0.011321805,
-0.015706629,
-0.009814946,
-0.03054444,
0.033042297,
0.013032294,
-0.008111245,
0.028616745,
0.0013609244,
-0.022806514,
0.013622819,
0.0019718132,
0.02235853,
-0.012217776,
0.025548726,
0.044391252,
0.024136893,
0.004208345,
0.0061937333,
0.02883395,
-0.013602457,
-0.040997423,
0.011342168,
0.006203915,
-0.007832952,
0.011111388,
-0.0075818086,
-0.02374321,
0.005453879,
0.04037296,
-0.011471134,
0.005423335,
0.004557909,
0.012631822,
0.002954326,
-0.016792653,
-0.019466989,
0.013229135,
0.016371818,
0.014172619,
0.00080985186,
-0.021639038,
0.024014717,
-0.016982708,
-0.024992138,
-0.02970277,
-0.00383163,
-0.019792797,
-0.0070659467,
-0.0048803226,
0.0145120025,
-0.02732709,
-0.01908688,
0.015543725,
-0.017647898,
-0.02637682,
0.009204058,
-0.044201195,
-0.011742639,
-0.0033531005,
-0.0077582872,
-0.00516201,
0.007839739,
-0.03651757,
-0.044065442,
0.0079008285,
0.021842668,
0.033368103,
0.009991425,
0.009346598,
-0.022141324,
0.019765645,
-0.00014360128,
-0.013826449,
-0.009733494,
-0.024421975,
-0.0021109602,
0.00060919183,
0.0017580021,
-0.013778936,
0.0024927657,
-0.011681551,
-0.0073306654,
-0.009149756,
0.047622174,
-0.010045727,
0.0023417403,
0.030001426,
0.028643895,
0.03241783,
-0.010629465,
0.011980208,
-0.0036483635,
-0.037413545,
-0.010588739,
0.0050568017,
0.0034396432,
-0.006159795,
-0.006064768,
-0.007513932,
-0.010005001,
-0.007968704,
-0.022942267,
-0.0045646965,
-0.011518647,
0.007819376,
0.012672548,
0.028562443,
0.007846527,
-0.006346456,
-0.01619534,
0.0034956413,
-0.0006087676,
-0.0018615138,
0.008179122,
-0.023091596,
-0.029404113,
0.030300083,
-0.02267076,
-0.004907473,
0.007222063,
0.0096045295,
0.0025911864,
0.021245355,
0.00024584032,
0.0008781526,
-0.008253786,
-0.000043430373,
0.010683766,
-0.005423335,
-0.015027864,
-0.007921191,
0.012475707,
0.004445913,
0.0065229344,
-0.0035295796,
0.0070116455,
-0.031114602,
-0.014525577,
0.030191481,
-0.013134109,
0.015027864,
0.0023383466,
-0.008443841,
-0.0155165745,
-0.014851385,
-0.027652899,
-0.032689337,
-0.007731137,
0.001915815,
0.0199557,
0.026417546,
0.038988277,
0.027340667,
0.012665761,
0.018190911,
0.013833237,
-0.010032151,
-0.023593882,
-0.004812446,
0.001878483,
0.04569448,
0.016765503,
0.009489139,
0.033856813,
-0.026091738,
0.018516717,
0.025643753,
-0.0090072155,
-0.018000856,
0.012339953,
-0.020553013,
-0.022630036,
-0.0047208127,
-0.012835452,
-0.012095598,
-0.030734492,
0.00026005195,
-0.019738495,
0.0008705165,
0.0014847991,
-0.007710774,
0.025494425,
0.002229744,
0.06450985,
-0.010222206,
-0.0002352346,
-0.0277615,
-0.016181765,
-0.0023230743,
0.0072831516,
0.020471562,
-0.0016010377,
0.005223099,
-0.010025363,
-0.003563518,
-0.0032784364,
0.00933981,
-0.015095741,
-0.008335238,
-0.015462274,
-0.016466847,
-0.01824521,
-0.03692483,
-0.045070015,
-0.049929976,
0.011939482,
0.029974276,
-0.03146756,
0.007710774,
0.0027048797,
-0.028345238,
0.033938266,
-0.02501929,
0.02377036,
-0.015774505,
0.017946554,
0.012095598,
0.0104054725,
-0.005657509,
-0.010867032,
-0.02773435,
0.006947163,
0.022630036,
0.026648326,
-0.01133538,
-0.0050398326,
-0.0018937552,
0.012455343,
-0.00043695516,
-0.055767357,
0.03670763,
-0.026064588,
0.012462131,
-0.0104054725,
0.002075325,
-0.037875105,
0.02279294,
-0.0048362026,
0.0025012502,
0.012394254,
0.004856566,
-0.02617319,
0.00044671242,
-0.0039605955,
0.023729635,
0.0042321016,
-0.018272363,
0.031820517,
0.0040148967,
0.018543867,
0.0018038187,
-0.0018547262,
0.009054729,
-0.013269862,
-0.000101178455,
0.010337596,
0.018285938,
0.0016120676,
0.00096384675,
0.014159044,
0.04034581,
-0.0033531005,
-0.008470991,
0.0005693144,
0.007391754,
0.01616819,
-0.010975635,
-0.0116544,
-0.0029458415,
-0.04040011,
0.017688625,
0.02018648,
-0.00037374513,
-0.0038214487,
-0.023865389,
-0.017647898,
-0.012075235,
-0.02276579,
-0.008491354,
-0.004659724,
-0.058319516,
-0.0277072,
0.022887966,
0.005358852,
0.0088511,
0.0052197054,
0.0138128735,
-0.00279821,
0.024883537,
-0.01064304,
0.0077718627,
0.013731422,
-0.0049414113,
-0.018584594,
0.0032920118,
-0.003658545,
-0.026078163,
0.021747641,
-0.004676693,
-0.03236353,
-0.0076225344,
-0.016236067,
0.027150612,
0.01596456,
0.00010828428,
0.020810945,
0.013806086,
0.005338489,
0.013514217,
0.0057661114,
-0.016154613,
-0.004340704,
0.014783508,
0.017186338,
-0.015625177,
0.0067638964,
0.010432622,
-0.034399826,
0.007731137,
-0.01706416,
-0.012889753,
-0.0060410113,
0.009014003,
-0.015055015,
-0.0035669117,
0.0062174904,
-0.00321056,
-0.01318841,
-0.0051348596,
0.00360085,
-0.016684052,
0.0072356383,
-0.022209201,
-0.016792653,
-0.0072492133,
-0.020118603,
-0.018842526,
0.008857887,
-0.020933121,
-0.022738637,
-0.0069980705,
-0.0354587,
0.04572163,
-0.028345238,
-0.020105029,
-0.02021363,
0.003149471,
-0.04126893,
-0.0015407973,
-0.0065670544,
-0.00080815493,
-0.0066417186,
-0.00067367457,
-0.016806228,
0.010792368,
-0.014023291,
0.0051755854,
-0.0073781786,
-0.0063125174,
-0.00042147082,
-0.038309515,
0.0113082295,
-0.005850957,
-0.044961415,
0.0054844236,
0.02128608,
-0.0067469273,
0.0033361316,
0.01573378,
-0.02148971,
-0.002579308,
-0.0032614672,
0.006108888,
-0.0076971985,
0.042463556,
0.019331235,
-0.041839093,
-0.0041778004,
-0.000025785128,
-0.00027383937,
-0.0177022,
0.020457987,
0.0090072155,
0.013636395,
0.013378465,
-0.014009716,
-0.046726204,
-0.0069980705,
-0.025182193,
0.029892825,
0.035757355,
-0.00043250076,
0.050011426,
0.025182193,
0.0043746424,
-0.01107745,
-0.010867032,
0.0047683264,
-0.0050805584,
-0.00016566116,
-0.008369177,
-0.01816376,
-0.0037467845,
-0.015543725,
-0.028725348,
-0.013846812,
0.0066519,
0.014226921,
-0.014552728,
0.019304086,
0.0103036575,
-0.005884895,
-0.008545655,
-0.026526147,
-0.009624892,
0.008294512,
0.0045680907,
0.017417118,
0.015448699,
-0.015883109,
0.019616317,
-0.013894326,
-0.0017919404,
0.0033887357,
-0.020933121,
0.003597456,
0.014023291,
0.20895112,
-0.007276364,
0.009672405,
0.008369177,
-0.00642112,
-0.024571303,
0.019969275,
0.0033412222,
0.008633895,
-0.017688625,
-0.0048531718,
0.027775077,
-0.016249642,
-0.0074053295,
0.006159795,
-0.014688482,
-0.021109601,
-0.0019446627,
-0.02530437,
0.010873821,
0.027001284,
-0.020037152,
0.0072356383,
0.0062955483,
0.042762212,
0.002424889,
-0.029784221,
-0.02276579,
-0.014091168,
0.022616459,
-0.030707343,
-0.0031613493,
-0.025155041,
0.026594024,
-0.019073306,
0.009360174,
-0.008423477,
-0.008260574,
-0.005457273,
0.013826449,
-0.012421405,
-0.009787796,
-0.021544011,
-0.0075750207,
0.0007356119,
-0.0018360602,
-0.0035363673,
-0.033992566,
-0.003699271,
0.034834236,
-0.0354044,
0.020349383,
0.0065399036,
-0.0040386533,
-0.008124821,
-0.016941981,
0.009760645,
0.021991996,
-0.018706772,
0.040617317,
-0.03323235,
0.00902079,
-0.030680193,
0.038038008,
-0.026689053,
0.0079008285,
-0.00046707538,
-0.011023149,
0.009747069,
-0.028725348,
0.008898613,
0.0053724274,
-0.015190767,
0.01532652,
-0.0056439335,
-0.00876286,
0.04086167,
0.015883109,
0.018435266,
0.038933977,
0.019195482,
0.012611459,
-0.029322661,
-0.008572806,
0.0045137894,
-0.0067808656,
0.008138396,
0.017104886,
0.0064856024,
-0.015340096,
0.0017885466,
-0.027394967,
-0.01616819,
0.009740282,
0.011287867,
-0.015584451,
-0.01619534,
-0.011152114,
-0.0056609027,
-0.0064245136,
-0.017077735,
0.08758788,
0.037630748,
0.002679426,
-0.032227777,
-0.013493855,
0.012849027,
0.014118318,
0.014539152,
-0.012862602,
-0.0057423543,
-0.040644467,
-0.0059561655,
-0.012414617,
-0.013561731,
-0.0006189491,
0.0147156315,
0.0065670544,
0.026594024,
-0.012353528,
-0.0073035145,
-0.031358957,
0.0038893253,
0.019263359,
-0.0024503428,
0.002971295,
-0.025820233,
0.00035295796,
-0.006590811,
-0.045504425,
0.0021805335,
0.032933693,
-0.009550228,
0.0032156506,
0.0069980705,
-0.0076225344,
-0.004971956,
-0.017675048,
-0.0062650037,
0.0018394539,
-0.017593596,
-0.0039775646,
0.0050534075,
0.028128034,
-0.004479851,
-0.0024724025,
0.02972992,
0.020905972,
-0.012910116,
-0.031657614,
-0.003247892,
-0.006590811,
0.023430979,
-0.006400757,
0.017620748,
-0.014267647,
-0.026689053,
-0.013005143,
0.001586614,
-0.005830594,
-0.014593454,
-0.0062005213,
0.016874105,
0.0011954753,
-0.0210553,
-0.019629892,
-0.17094025,
0.009597741,
0.01576093,
-0.011532223,
0.015937408,
0.022806514,
0.010554801,
-0.0035533365,
-0.021734064,
0.0025351883,
0.019996425,
0.0060002855,
-0.00054598186,
-0.0062717916,
-0.010581951,
0.0059833163,
-0.0037026647,
0.02929551,
-0.007045584,
0.013616032,
0.0015976438,
-0.02796513,
0.022833664,
-0.010805944,
0.004652936,
0.00032601945,
-0.0055421186,
-0.0055590877,
-0.0019344811,
-0.016018862,
0.0008522747,
0.00928551,
0.043929692,
0.0053079445,
0.020145753,
0.0047208127,
-0.019914974,
-0.0055998135,
0.0051144967,
0.02021363,
0.037929405,
0.010778793,
0.00864747,
-0.019181907,
-0.013887539,
0.03953129,
0.005145041,
-0.008219847,
0.010025363,
-0.02926836,
0.019657044,
-0.014294798,
-0.003013718,
0.016480422,
0.02678408,
0.029811373,
0.0021109602,
0.013208773,
-0.014036867,
-0.022616459,
-0.0016460059,
0.0049787434,
0.046373244,
-0.015801657,
-0.005338489,
-0.0054504853,
-0.009156544,
0.0081044575,
-0.01862532,
0.013527793,
-0.0058441693,
-0.0039877463,
-0.018638896,
-0.03543155,
0.016534723,
0.009061517,
-0.022535007,
0.010514075,
0.0034990353,
0.0073035145,
-0.0054504853,
0.021801941,
-0.010629465,
-0.016005285,
0.011674764,
-0.021747641,
-0.007887253,
0.021652613,
0.005182373,
0.0011657794,
0.020892397,
-0.02218205,
0.0025402792,
-0.024231922,
0.04477136,
0.018557444,
0.0014347401,
0.023593882,
-0.010181479,
-0.021706915,
0.016996283,
0.0026556693,
-0.0045884536,
0.011199627,
0.032553583,
0.012475707,
0.0037705412,
0.016670477,
0.06174049,
-0.018543867,
0.0049855313,
-0.0014321948,
0.022928692,
0.023444554,
-0.0027065766,
0.030300083,
-0.0020396898,
0.0037433906,
0.0034752784,
-0.021544011,
0.056907684,
0.021829093,
-0.01839454,
0.006024042,
-0.0052197054,
-0.037033435,
-0.11468419,
-0.022887966,
0.0086135315,
0.03505144,
-0.021611888,
0.0036280006,
0.0065500853,
0.034725633,
-0.015883109,
0.036028862,
-0.0021245354,
0.0049549867,
0.006495784,
-0.0049991063,
0.015014289,
0.014159044,
0.0036144252,
-0.015638752,
-0.04569448,
0.02059374,
-0.015340096,
-0.0065229344,
-0.006336274,
0.0075750207,
0.017444268,
-0.010955272,
-0.012781151,
0.018937552,
0.0064075445,
0.019643469,
-0.00011305685,
-0.020362958,
0.04596599,
0.00046113617,
-0.0065195407,
-0.017742924,
-0.009828522,
-0.013493855,
0.038390964,
-0.018014431,
0.02279294,
0.02235853,
0.018000856,
-0.01376536,
-0.02484281,
-0.007534295,
0.008633895,
0.0033751605,
0.012971205,
-0.019996425,
-0.0036483635,
-0.021394683,
-0.021652613,
-0.012862602,
0.02568448,
-0.013229135,
0.006712989,
0.044119745,
-0.018055158,
0.00119293,
-0.039857097,
0.024028292,
-0.006984495,
-0.013554943,
0.02484281,
-0.02151686,
0.011919118,
-0.017444268,
0.038553867,
0.013677121,
-0.00012758667,
0.0006308275,
-0.011457559,
0.004829415,
-0.0041744066,
0.013677121,
-0.00917012,
-0.010989211,
0.014539152,
-0.0034786721,
-0.021123176,
-0.033476707,
-0.0005328308,
-0.028698197,
0.038852528,
0.00088409183,
-0.0012667457,
-0.0020464773,
0.024897112,
-0.0047513572,
-0.023851812,
0.05544155,
0.028100884,
-0.041350383,
0.0041845883,
0.0059833163,
-0.027137037,
0.0043712487,
-0.005402972,
0.032282077,
-0.022412831,
0.009299085,
-0.069288366,
0.036110315,
-0.0009748767,
-0.0094144745,
0.01307302,
-0.015014289,
-0.0000028221125,
-0.0017885466,
-0.008409902,
0.007398542,
-0.04428265,
0.032580733,
0.0015433426,
-0.009930337,
-0.028019432,
-0.006064768,
0.045857385,
-0.007710774,
0.021381106,
0.0050364383,
-0.014131893,
-0.01419977,
0.021123176,
0.0043950053,
-0.0014644362,
-0.012387467,
-0.033829663,
-0.012964417,
0.0024333736,
0.03822806,
-0.003984352,
-0.028508143,
-0.0015908562,
0.022616459,
-0.0077515,
-0.015367246,
-0.031630464,
0.018095883,
0.0015204343,
0.023485279,
-0.008620319,
-0.038010858,
0.011681551,
-0.004988925,
0.00019259966,
-0.0147156315,
-0.019534865,
0.0019005429,
0.00095366524,
-0.02172049,
0.031250354,
0.021231778,
0.010636252,
-0.033911116,
-0.022317803,
0.012882966,
-0.008124821,
-0.009204058,
0.016276792,
0.0091090305,
0.017593596,
0.008342026,
0.032553583,
0.00026302156,
-0.012231351,
-0.0035838808,
-0.016127463,
-0.008342026,
0.018285938,
-0.039612744,
-0.0031783185,
-0.008253786,
0.0244084,
0.005908652,
0.0028779649,
0.009041154,
-0.028426692,
-0.011634037,
-0.009217633,
0.0040013213,
0.015842382,
0.0038248424,
-0.036653325,
0.00731709,
0.02463918,
-0.0007504599,
-0.0025402792,
0.021245355,
-0.00061513105,
-0.0051348596,
0.0013023809,
0.029947124,
-0.0023400434,
0.02591526,
0.0032580735,
0.00371624,
-0.0023604063,
0.00008277755,
0.0051925546,
0.020905972,
0.0017936373,
0.012577521,
-0.01532652,
-0.035540152,
-0.006920012,
0.018733922,
-0.02929551,
-0.032553583,
0.0021448983,
-0.007846527,
0.015163617,
0.001692671,
-0.0038078735,
0.004812446,
0.0017028524,
-0.001350743,
-0.009801371,
-0.022372104,
-0.019562015,
0.008043369,
0.02481566,
-0.004160831,
-0.008111245,
0.005443698,
0.012733637,
0.012998356,
0.029838523,
-0.024517003,
0.0037026647,
-0.02307802,
0.017213488,
-0.025874533,
-0.026906257,
-0.00766326,
-0.007975493,
0.00688268,
-0.0045918473,
0.026526147,
-0.03858102,
0.105615884,
0.022535007,
-0.0027133643,
0.015380822,
-0.025005713,
0.017742924,
0.01749857,
-0.0025725204,
-0.0032971024,
-0.02637682,
-0.010934909,
-0.024326948,
0.0044968203,
-0.023349527,
-0.016616175,
0.009319448,
-0.01752572,
0.015937408,
-0.016643325,
-0.007853314,
-0.0006817349,
0.008756072,
0.01075843,
0.014729207,
-0.015896684,
0.0048192334,
0.010493712,
0.021218203,
-0.009360174,
-0.05145041,
0.006468633,
-0.011986995,
-0.048436694,
-0.009448413,
-0.004126893,
-0.027680049,
0.008063732,
0.0032648612,
-0.0021669583,
0.019602742,
-0.0010605708,
-0.0045646965,
-0.008294512,
-0.014172619,
0.031250354,
0.01842169,
-0.01908688,
-0.006750321,
-0.026851956
] |
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ. | [
-0.014494091,
0.015225984,
-0.01586639,
-0.026230516,
0.0041397684,
0.011056809,
-0.0040744212,
0.008985291,
-0.00037186852,
-0.020662902,
0.01157959,
-0.002934106,
-0.0092270775,
-0.0022381544,
-0.009449258,
0.0113835465,
0.041116692,
0.0017235422,
-0.020218538,
-0.0021009245,
-0.049925543,
0.003154654,
0.0057342495,
-0.019303672,
0.008044286,
0.014141214,
0.020061705,
-0.033771627,
0.0011239782,
-0.0032298036,
0.0024194939,
-0.009932831,
0.009874018,
-0.008266468,
-0.013487739,
-0.00969758,
0.014637856,
-0.020022497,
0.026335072,
0.0049794847,
0.011808306,
0.013350509,
-0.007952799,
-0.0116122635,
0.008371023,
0.007776361,
0.0068026823,
-0.012161183,
-0.009978574,
0.022793233,
0.035993442,
-0.006214554,
-0.007534575,
0.007992008,
-0.0359673,
-0.0043194746,
0.000709838,
0.012370295,
0.007874383,
-0.042920284,
-0.009187869,
-0.017813748,
-0.0066001047,
0.00041618236,
-0.0033784695,
0.010168082,
-0.0043096724,
0.034137573,
0.0066393134,
0.00069962745,
0.026870921,
0.026583392,
0.011945536,
0.0066262437,
0.010311847,
-0.018414946,
-0.011298595,
0.0021973122,
-0.020545276,
-0.0044240304,
-0.00530949,
-0.032752205,
0.000099501885,
0.014794691,
0.015931739,
-0.008436372,
0.0039241216,
0.010253034,
-0.0033196567,
-0.009632232,
-0.0055284044,
0.0063321795,
0.02230966,
0.022218175,
0.0017121064,
-0.008841527,
0.009932831,
0.023015415,
0.0035745122,
-0.022139758,
-0.01719948,
0.02206134,
-0.0022528574,
-0.023838794,
-0.020061705,
-0.004384822,
0.0063811904,
0.010997997,
0.031419113,
-0.0018166625,
-0.018140486,
0.027184589,
0.004463239,
-0.045873996,
0.037483368,
-0.0024374644,
-0.019813383,
-0.0069137732,
-0.010743141,
0.00040147913,
0.036542363,
0.027524397,
0.011056809,
-0.026491905,
0.026139028,
0.0015740596,
0.015696486,
-0.015840251,
-0.01508222,
0.0050644367,
-0.004005806,
-0.01252713,
-0.0038914478,
0.020100912,
-0.0071620937,
0.0012840797,
-0.0050611696,
0.02637428,
0.0016279714,
-0.0095668845,
0.012553268,
0.032490812,
0.0007470044,
-0.015696486,
0.019421298,
0.03390232,
0.030791776,
0.009481933,
-0.0035745122,
-0.007586853,
0.010651655,
-0.025080398,
0.014899246,
-0.01934288,
-0.010651655,
0.006939912,
0.0025828627,
0.036150277,
0.01909456,
0.0029210364,
0.0039731325,
-0.012533664,
0.009717184,
-0.0033408946,
0.014062798,
0.01858485,
0.003086039,
0.012951889,
0.0031350497,
0.004616806,
-0.0009475398,
0.018271182,
-0.010991462,
-0.0050644367,
-0.023498986,
0.0076325964,
0.021473212,
0.0029275713,
-0.052121222,
-0.019800315,
0.017121064,
-0.0033686673,
0.023982558,
0.00067920634,
-0.0130303055,
-0.018336529,
0.017395524,
-0.012233065,
-0.0024913761,
-0.003280448,
-0.013683781,
0.01692502,
-0.008782714,
-0.028752932,
-0.6407199,
-0.010318382,
0.03385004,
-0.022322731,
0.019068422,
0.019761106,
0.020270817,
-0.018976934,
-0.010187686,
-0.0007421034,
0.0072274413,
-0.00010649612,
0.010828093,
-0.023995629,
-0.025603179,
-0.03790159,
0.0039567957,
-0.011651472,
0.025485553,
-0.012945354,
-0.0067177303,
-0.010834628,
-0.017134134,
-0.005133052,
-0.036411665,
0.0009499903,
0.034215987,
0.030033743,
-0.0067700082,
0.020806666,
-0.00967144,
-0.0022659271,
0.005727715,
-0.0072601154,
0.04629222,
0.036019582,
-0.03254309,
0.021590838,
-0.012004348,
0.02877907,
-0.006508618,
-0.004675619,
-0.0005869029,
0.0030533653,
-0.021995993,
0.0043946244,
-0.004417496,
0.0048128488,
0.01748701,
-0.019591201,
0.0053911745,
-0.009691045,
-0.0065151528,
-0.0014531666,
0.015265193,
-0.0010962056,
0.010723537,
-0.0047605704,
0.005668902,
0.008083494,
0.008371023,
0.014324187,
-0.016454518,
-0.02149935,
0.002145034,
0.02152549,
-0.014820829,
-0.008070425,
0.025407135,
-0.010775815,
0.0053813723,
0.020858945,
-0.0101354085,
-0.019029213,
-0.0009793967,
0.011788702,
0.0054924632,
-0.02123796,
0.0011321467,
0.029014321,
-0.002708657,
-0.016728979,
0.0010520959,
0.012736241,
0.024884354,
-0.01854564,
-0.0033719346,
0.014546369,
-0.0056852386,
0.017264828,
-0.004015608,
0.025720805,
0.011638403,
-0.050396048,
-0.019617341,
0.027132312,
-0.005793062,
0.00015417943,
-0.016964229,
-0.015997086,
-0.0030909402,
-0.0026073682,
0.010880371,
-0.002901432,
0.012801589,
0.009730253,
-0.029667797,
-0.0019783978,
0.05321906,
-0.033823904,
-0.00042557606,
0.009893622,
-0.020310026,
0.009808671,
0.012670894,
-0.003175892,
0.00046233408,
0.024923563,
-0.0029275713,
0.011919397,
0.026282793,
0.016559074,
-0.0021858762,
-0.023263736,
0.0077894307,
0.01589253,
-0.008050821,
-0.013618434,
-0.0058486075,
-0.022218175,
0.0019293871,
-0.0028540553,
0.011906328,
-0.03398074,
0.038581207,
-0.00069064216,
0.016846605,
-0.009926296,
-0.009664906,
-0.022963136,
-0.0255509,
-0.010697397,
-0.005280084,
-0.029354129,
-0.012559803,
0.0076325964,
-0.009691045,
0.005479394,
-0.009044104,
-0.005851875,
0.0008495184,
0.0007482297,
-0.03123614,
-0.008665088,
0.00093937136,
-0.013788338,
-0.0072339764,
-0.0004135276,
0.023276806,
-0.021355586,
-0.023864932,
0.009436189,
0.00030284515,
0.024335437,
-0.000032469576,
-0.009834809,
-0.026949339,
0.014481022,
0.008390628,
-0.019068422,
-0.002082954,
-0.013971311,
-0.0070967465,
0.010155013,
-0.008403698,
-0.006214554,
0.004116897,
0.0040940256,
-0.03011216,
-0.009096382,
-0.0025567238,
-0.023838794,
0.013252487,
-0.016977299,
0.026504975,
0.0057179127,
0.042920284,
-0.0018428015,
0.020231608,
0.046658166,
-0.026583392,
0.01278852,
-0.040332522,
0.006560896,
-0.0052637467,
-0.029641658,
0.014873107,
0.014428744,
0.005168993,
0.025407135,
-0.007488832,
-0.024126323,
0.014833898,
-0.0055610784,
-0.0012848966,
-0.022440355,
-0.011311664,
-0.018009791,
0.001056997,
0.006724265,
0.0042443248,
0.00043823716,
-0.00018521953,
0.0074365535,
0.010324916,
0.028047178,
-0.01699037,
-0.0062799016,
-0.017931374,
-0.0052898857,
0.013141396,
-0.010939184,
0.022544913,
-0.015435097,
-0.018258112,
-0.015448166,
0.016794326,
0.009860949,
-0.014088936,
-0.019303672,
-0.0045939344,
0.0010210559,
-0.011906328,
0.009874018,
-0.013892894,
0.008704296,
-0.0021058256,
-0.009612627,
0.027080033,
-0.008083494,
0.017879095,
0.0053617684,
-0.0067111957,
0.0019473577,
-0.016911952,
-0.02637428,
0.023891073,
-0.016336894,
-0.026818644,
-0.0075215055,
-0.020532208,
-0.008540927,
-0.0090571735,
-0.021852229,
-0.00077641086,
-0.008103099,
0.009194403,
0.006894169,
0.017970582,
0.008482114,
0.023067692,
-0.016023224,
0.0011942269,
-0.022714816,
0.0030484642,
-0.011422755,
0.002292066,
-0.0057603884,
-0.026818644,
-0.0068157515,
-0.010860766,
0.0041822447,
0.0301383,
-0.033484094,
0.0052604796,
0.014467953,
0.009004896,
-0.0066915913,
-0.0077567566,
0.012324552,
0.007697944,
-0.01318714,
0.0059498963,
0.035549078,
-0.003069702,
-0.007031399,
-0.01725176,
-0.010717002,
0.0030451969,
0.0008470679,
0.00410056,
-0.0024652372,
0.010860766,
-0.014742412,
-0.0076456657,
0.0051134476,
0.008534393,
-0.011507708,
0.019983288,
0.008848061,
-0.011932466,
-0.011847515,
-0.013814476,
-0.017683053,
0.041351944,
0.0018656731,
0.008900339,
-0.018872378,
-0.004688688,
-0.024309296,
-0.029249573,
-0.0059956396,
-0.009070243,
-0.0125205945,
0.014546369,
-0.00095407455,
0.02210055,
0.023917211,
0.028047178,
0.008390628,
-0.021773811,
-0.045560326,
0.0146770645,
-0.021930644,
0.02666181,
0.014350327,
-0.021826088,
0.02130331,
-0.033144288,
-0.0006738968,
-0.010527493,
-0.0033016861,
0.031183861,
0.0044469023,
-0.010899975,
0.00039269807,
-0.0037542179,
-0.0044991802,
-0.002393355,
0.039966576,
-0.0029243038,
0.0036431272,
0.0101354085,
-0.006126335,
-0.024243949,
0.008880735,
0.037718616,
0.028099455,
0.023119971,
0.01115483,
0.0012530397,
0.021290239,
-0.000016119919,
0.004678886,
0.010109269,
0.015121428,
-0.0013036841,
0.025511691,
-0.011762563,
-0.010155013,
0.0033555978,
0.017304037,
0.014088936,
0.0065118857,
0.030242857,
0.035627495,
0.0072993236,
-0.016075503,
0.004263929,
-0.0048651267,
0.014716273,
0.00028487458,
0.024152463,
-0.02445306,
0.023930281,
-0.026269725,
-0.0075084358,
-0.012318017,
0.0008237878,
0.0023231062,
0.01914684,
-0.007626062,
-0.0042606615,
0.005472859,
-0.015605,
-0.02204827,
0.006015244,
-0.008005078,
-0.024139393,
-0.022375008,
-0.008985291,
0.0015078952,
-0.016245406,
-0.016114712,
0.005159191,
-0.006038116,
-0.0077110133,
0.0099655045,
0.0084298365,
0.012579408,
0.038241398,
-0.018192764,
0.009887087,
0.018401876,
0.0020649834,
-0.01914684,
0.011520777,
-0.015931739,
-0.011239782,
0.02856996,
0.015252124,
0.007449623,
-0.016101642,
0.00927282,
-0.01909456,
-0.0033850041,
-0.0034209453,
0.0091159865,
-0.025276441,
0.02445306,
0.022976207,
0.012808124,
-0.019003075,
-0.0166767,
-0.03202031,
-0.026400419,
-0.016036294,
-0.0047573033,
0.015997086,
-0.024374643,
-0.005998907,
0.013749129,
-0.003907785,
-0.019316742,
0.038842596,
-0.03607186,
0.006126335,
-0.0032673785,
0.009318564,
0.013670712,
0.003979667,
0.012278808,
0.009867484,
-0.03868576,
-0.015265193,
-0.017042646,
0.024021767,
0.020009426,
-0.035888888,
-0.00023096282,
-0.0030206915,
0.0006689958,
-0.02396949,
-0.0067634736,
0.0062537626,
0.022701746,
0.0045547257,
-0.011847515,
-0.009181334,
0.004192047,
0.012246135,
0.0044240304,
0.0024064244,
-0.008965687,
0.006139404,
0.011997814,
0.0075737834,
-0.023329083,
0.021852229,
-0.028413124,
-0.013383183,
0.009442724,
0.018467223,
0.00873697,
-0.009756393,
0.008723901,
-0.006688324,
-0.0019457239,
-0.0005979303,
-0.023538195,
-0.00847558,
-0.029641658,
0.02956324,
0.029981466,
0.020872014,
-0.022544913,
0.025524762,
0.012272274,
0.0032347047,
0.010481751,
-0.0048291855,
0.02285858,
-0.013879824,
0.00927282,
-0.023080762,
-0.011128691,
0.009501537,
-0.0021613708,
0.020310026,
0.029145017,
-0.010422938,
-0.0505006,
0.005100378,
-0.027655093,
-0.027184589,
-0.0017023042,
0.0074692275,
0.014794691,
-0.038241398,
0.007292789,
0.015029942,
0.015578861,
-0.008096565,
-0.0088284565,
0.03369321,
0.0053519662,
0.015317471,
-0.009436189,
0.020597555,
-0.0021123602,
0.0017905234,
-0.0134616,
-0.0028524215,
0.02125103,
-0.013958241,
-0.0042606615,
0.030530386,
0.004623341,
0.024413852,
0.0053029554,
-0.010520959,
-0.03207259,
-0.0048978003,
-0.022427287,
-0.008057356,
-0.014873107,
-0.014559439,
-0.0063811904,
-0.0027364295,
-0.0011509341,
-0.00076579186,
0.012076232,
-0.0177484,
-0.032516953,
0.036829893,
-0.011076413,
-0.000830731,
-0.025276441,
0.020035565,
0.020218538,
-0.004263929,
-0.015578861,
-0.0084298365,
-0.00875004,
0.0019424566,
0.02641349,
0.03126228,
-0.012010884,
-0.006570698,
-0.01857178,
0.020244678,
0.003907785,
-0.012997632,
-0.008031216,
0.011690681,
0.007848243,
-0.0039992714,
-0.011651472,
-0.008273003,
-0.010056991,
0.006113265,
0.0084298365,
-0.0048651267,
-0.0052016666,
-0.012664359,
0.02956324,
-0.010429473,
0.003086039,
-0.008684692,
-0.0033212902,
-0.0036463945,
-0.023316013,
-0.0029618787,
-0.008482114,
-0.0030223252,
0.02289779,
0.00090833125,
0.008364489,
0.033327263,
0.00015172889,
-0.008442907,
-0.0011141761,
-0.014742412,
0.04650133,
-0.00006422441,
0.015761834,
0.0050775064,
0.0074953665,
0.015435097,
-0.008880735,
-0.0029961863,
0.008854596,
-0.04310326,
-0.018872378,
0.020519137,
-0.00091895025,
-0.007449623,
0.03039969,
-0.028282428,
-0.014624787,
-0.034921743,
-0.018480293,
0.00833835,
-0.020270817,
-0.003280448,
0.02342057,
0.0021058256,
0.0080900295,
0.004721362,
-0.005342164,
-0.027655093,
0.019068422,
-0.018937726,
0.037744757,
0.014350327,
0.017970582,
-0.040044993,
-0.007854778,
-0.0011509341,
-0.035078578,
0.011285526,
-0.01640224,
-0.030582663,
-0.0035777795,
-0.008652018,
-0.008083494,
-0.000022718492,
-0.017330175,
-0.009220542,
0.015408957,
0.035993442,
0.0059858374,
-0.01778761,
0.010520959,
-0.030451968,
-0.017343245,
0.00021952699,
-0.015382818,
0.0041626403,
0.018624058,
-0.008024681,
0.0050284956,
-0.019277534,
-0.013905963,
-0.026596462,
0.0026253387,
-0.011226713,
0.01076928,
-0.01693809,
0.0030599001,
-0.006521688,
0.012246135,
0.0055970196,
-0.01938209,
0.012847332,
0.0099066915,
0.010965322,
0.019525854,
-0.0064857462,
0.0013494274,
0.012814659,
-0.031837337,
-0.037849315,
-0.0057963296,
-0.022218175,
0.03876418,
0.017147202,
0.021316377,
-0.015984016,
0.00471156,
-0.06858881,
-0.026792504,
0.018062068,
0.019447437,
-0.0015609901,
0.011906328,
0.0075999224,
-0.018885449,
-0.0002013522,
0.009468863,
0.0038195655,
-0.020832805,
0.020623693,
0.014206562,
0.016467588,
-0.0126316855,
-0.032360118,
-0.018088209,
0.026870921,
-0.009828275,
0.020963501,
0.01401052,
-0.015931739,
0.021368656,
-0.018767823,
0.0037672876,
-0.017421663,
0.0018885448,
-0.016624423,
-0.008684692,
0.013167536,
-0.008384094,
-0.028909765,
-0.0038522393,
-0.0071163503,
-0.019369021,
0.0025844965,
0.01022036,
-0.006972586,
-0.027733508,
0.011416221,
-0.014428744,
0.012050092,
0.015265193,
-0.014637856,
0.036829893,
0.0109849265,
-0.0066752546,
-0.014716273,
-0.015461235,
-0.014637856,
-0.004789977,
-0.017709192,
-0.006152474,
0.0072013023,
-0.0019424566,
0.007456158,
-0.049089096,
-0.0047180946,
-0.010899975,
0.009129056,
-0.030295134,
0.027681231,
-0.0039241216,
-0.030190578,
-0.001293065,
-0.007959334,
-0.013853685,
-0.037535645,
-0.005410779,
0.0033719346,
-0.020218538,
0.013180605,
-0.0027266275,
-0.01115483,
-0.0077828956,
-0.017852956,
-0.003138317,
0.0015127963,
-0.009292425,
0.18380965,
-0.015787974,
-0.0010888539,
0.012259205,
-0.01289961,
-0.0050023566,
0.0062929713,
0.011076413,
-0.007103281,
0.012938819,
0.014350327,
-0.003285349,
0.004868394,
-0.00072413275,
0.02609982,
-0.02747212,
-0.013056445,
-0.00041904132,
-0.0009058807,
-0.012487921,
0.002770737,
-0.0042083836,
0.019538924,
-0.011390082,
0.042685032,
0.0007898888,
-0.013422391,
0.007371206,
0.010266104,
0.004669084,
-0.029537102,
-0.0055480087,
-0.014075867,
0.0035516405,
0.020545276,
0.0028899964,
-0.0045351214,
0.008769644,
0.0028246487,
0.002597566,
0.019159907,
-0.008109634,
-0.022113618,
0.011324734,
-0.0016843337,
0.034869466,
0.009096382,
-0.0055022654,
-0.01884624,
0.0058845486,
-0.026570322,
0.007998543,
0.021081127,
0.00003264826,
-0.0006734884,
0.0040613515,
0.011991279,
0.013304765,
-0.0071228854,
0.016363032,
-0.04820037,
0.01561807,
-0.012050092,
0.045455772,
0.013618434,
0.007835174,
0.006861495,
0.0010586306,
0.019369021,
-0.023263736,
-0.0069595166,
-0.010821558,
-0.017630775,
-0.014873107,
-0.023512056,
-0.03628097,
0.014572509,
0.0022969672,
0.003927389,
0.011076413,
0.025760012,
-0.002486475,
-0.029223435,
0.02149935,
0.021486282,
-0.017656913,
0.031941894,
0.009762927,
-0.029641658,
-0.016219268,
0.0018428015,
-0.012710103,
-0.0038881805,
0.008514789,
0.016624423,
-0.0019538924,
0.00080091617,
0.0050709713,
0.010403333,
-0.0124617815,
-0.02770737,
0.08965687,
0.036829893,
0.0031089108,
-0.0047082924,
0.030739497,
-0.011318199,
-0.0025959322,
0.004018876,
-0.009083312,
0.015487375,
-0.037718616,
0.010697397,
0.00041597814,
-0.00645634,
0.022035202,
0.0054859286,
-0.03628097,
0.0255509,
-0.010723537,
0.00067838945,
-0.030321274,
0.0015136132,
0.030739497,
0.014206562,
0.009240147,
-0.019721897,
0.013879824,
0.015225984,
-0.017826818,
-0.014755482,
-0.0015078952,
0.007475762,
0.0354968,
0.017526219,
-0.0015748765,
0.0085474625,
-0.015160637,
-0.03523541,
0.0049762176,
-0.025158815,
0.0016296051,
0.037274256,
0.015212915,
0.0052768164,
-0.007809035,
0.03068722,
0.0008756575,
-0.026844783,
-0.026191307,
-0.00471156,
-0.013291696,
-0.01990487,
0.0065282225,
0.011233248,
-0.030608803,
-0.014180423,
-0.016820464,
0.020793598,
-0.005453255,
-0.011736424,
0.016376102,
0.00082460465,
-0.026714087,
-0.005740784,
-0.0070640724,
-0.16206197,
0.021564698,
0.021643115,
-0.004502448,
0.025171885,
0.017317107,
0.02072825,
-0.0011051908,
-0.0058192015,
0.01963041,
0.044567045,
0.009240147,
-0.027785787,
-0.025433274,
0.011128691,
0.0038261004,
-0.0056656343,
0.03949607,
0.02075439,
0.018336529,
0.039443795,
-0.018676337,
0.0004925573,
-0.008867665,
0.015278262,
0.023851864,
0.00235578,
0.006387725,
-0.020257747,
-0.017931374,
-0.008743505,
-0.021120336,
0.022780163,
-0.0048128488,
0.007626062,
0.0064661424,
0.0054499875,
0.007841708,
-0.0062080193,
0.025198024,
0.03207259,
0.0011011065,
0.020558346,
-0.0038555067,
0.0040776883,
0.03066108,
-0.038921013,
-0.008710831,
0.0020682507,
-0.025629317,
0.039835878,
-0.0027217264,
-0.0055741477,
0.024074046,
0.024805939,
0.025746943,
-0.0014760382,
0.024387714,
0.011520777,
0.0072797197,
0.008900339,
-0.0134616,
0.013278627,
0.0072013023,
0.012357226,
-0.025106536,
-0.006645848,
0.041770168,
-0.011860584,
0.006557629,
-0.015029942,
-0.014428744,
0.02074132,
-0.01994408,
0.014846968,
0.028700653,
0.00032061152,
-0.015970947,
0.0046560145,
0.010266104,
-0.008299141,
0.0079789385,
-0.024387714,
0.0015168805,
-0.024165532,
-0.00033225157,
0.0020110714,
0.018088209,
0.012644755,
-0.017212551,
0.0111025525,
-0.036986727,
-0.009214007,
-0.009939366,
0.009122521,
0.032360118,
-0.01934288,
-0.017382454,
-0.019970218,
0.010625515,
0.012755846,
-0.004427298,
-0.018349597,
0.005626426,
-0.0068418905,
0.0071686287,
-0.02451841,
0.005221271,
0.038136844,
-0.008573601,
0.003417678,
0.0091159865,
0.018088209,
0.008253398,
-0.0113835465,
0.008848061,
0.0033948063,
-0.012951889,
-0.0035810468,
-0.029458685,
0.066602245,
0.0029406408,
-0.011069879,
0.027236868,
-0.015944807,
-0.012736241,
-0.14972435,
-0.003043563,
0.010141943,
0.00665565,
-0.018271182,
0.018231973,
-0.024034837,
0.004133234,
-0.022793233,
0.015944807,
-0.0052637467,
-0.0012718271,
0.009579954,
-0.0019048817,
0.00821419,
0.006240693,
-0.002450534,
-0.023538195,
-0.018767823,
0.029667797,
0.011318199,
-0.0059074205,
-0.00080500037,
-0.01401052,
0.009017965,
0.0055349395,
-0.031053167,
0.0027413305,
0.021656185,
0.02636121,
0.008325281,
-0.0060348483,
0.03230784,
-0.006240693,
0.0051559233,
0.002886729,
-0.008495185,
-0.029667797,
0.046449054,
-0.024243949,
-0.011586124,
0.003875111,
-0.004884731,
-0.0101942215,
-0.0042671966,
-0.005799597,
-0.0073385322,
-0.00928589,
0.032752205,
-0.009762927,
-0.01614085,
-0.040306382,
-0.029510964,
-0.0014548004,
0.0068026823,
-0.013683781,
0.0034144106,
0.0143372575,
-0.003737881,
-0.03719584,
0.008469045,
0.0023329083,
-0.01990487,
0.0012759113,
0.040750746,
-0.018689405,
-0.013010701,
-0.0026090017,
0.020649832,
-0.04041094,
-0.0015503712,
-0.036829893,
-0.021486282,
-0.0038293677,
-0.004005806,
0.014036658,
-0.012135044,
0.0014253939,
-0.022244314,
-0.023080762,
-0.024126323,
-0.017447801,
0.014820829,
-0.009762927,
0.032360118,
-0.00017337527,
-0.001525049,
-0.013396252,
0.019290604,
-0.015748765,
-0.0016230703,
0.036699194,
0.0056754365,
-0.02287165,
0.006420399,
0.01964348,
0.035392243,
-0.0075803185,
0.025524762,
0.035418384,
-0.013062979,
-0.010442542,
-0.05243489,
0.028230151,
-0.01250099,
0.006100196,
0.0078025,
-0.02396949,
-0.0037868917,
-0.029484823,
0.013252487,
0.025511691,
-0.011631868,
-0.0012236333,
-0.022231244,
0.018807031,
-0.039443795,
-0.03787545,
0.015212915,
0.0035777795,
0.019172978,
0.023799585,
-0.002576328,
-0.01129206,
0.024283158,
0.006312575,
-0.013892894,
0.023106901,
0.0012840797,
0.018101277,
-0.004894533,
0.01075621,
-0.008933013,
-0.03066108,
-0.023904141,
0.0022953334,
-0.0132002095,
-0.027236868,
-0.0070836768,
0.03259537,
0.025733873,
0.033928458,
-0.01373606,
-0.031131582,
-0.0020274085,
-0.009331633,
-0.024832077,
-0.006577233,
-0.03575819,
0.019917939,
-0.0007723266,
-0.01776147,
0.04378287,
0.0093969805,
0.0015176974,
-0.05248717,
0.0017905234,
0.017774539,
0.017160272,
-0.014023589,
-0.004368485,
-0.03259537,
0.013422391,
0.021277169,
0.0067177303,
0.011461964,
0.0027102905,
-0.024348505,
-0.02582536,
0.008586671,
-0.022636399,
0.014585578,
-0.008292607,
0.012278808,
0.016519867,
-0.013788338,
0.014663995,
-0.000031984575,
-0.010122339,
0.012840798,
-0.027341424,
0.009063709,
-0.012030488,
-0.0025795954,
0.004169175,
0.014990733,
0.048278786,
0.0052343407,
-0.018428015,
0.034242127,
-0.0031170791,
0.010063526,
0.0042606615,
0.010736606,
0.017068787,
-0.003633325,
0.0053977096,
0.019708827,
0.016036294,
0.013487739,
-0.0013584127,
0.04362604,
0.00010557717,
0.002033943,
0.01478162,
-0.025380997,
-0.013154466,
0.010749675,
-0.0052376078,
-0.05410779,
-0.032516953,
0.010056991,
-0.0072993236,
0.015761834,
0.012213461,
0.0067308,
-0.0322817,
0.0017055717,
0.0018264647,
0.005757121,
-0.024126323,
0.01278852,
0.017931374,
0.012108905,
0.0012636586,
0.0004027044,
-0.00075721496,
0.032438535,
0.01718641,
0.0027870738,
0.030478107,
0.021342516,
-0.0033310924,
0.0021107267,
-0.019800315,
-0.0031301486,
-0.001534851,
0.00064285676,
0.013180605,
0.03818912,
-0.039757464,
0.06153127,
-0.00018807848,
-0.027289147,
0.00083726575,
-0.03280448,
0.016781256,
0.0065151528,
0.010658189,
0.007854778,
-0.009880553,
0.03685603,
0.00503503,
0.013370113,
-0.022754025,
-0.031628225,
0.04459318,
-0.021891436,
0.008782714,
0.015356679,
-0.008194585,
0.01964348,
-0.013357043,
-0.0026580126,
0.02291086,
-0.017905235,
-0.010422938,
0.0077567566,
-0.005904153,
-0.008109634,
-0.024230879,
0.038032286,
-0.003659464,
-0.04950732,
0.002635141,
-0.013141396,
0.004404426,
-0.02152549,
-0.050082378,
0.0013821011,
0.038921013,
-0.0034078758,
0.035888888,
-0.02770737,
-0.014637856,
-0.007867848,
-0.008397163,
-0.01478162,
-0.023747308,
0.014951524
] |
Interleukin-15 (IL-15) is a cytokine produced in the normal brain that acts on its specific receptor IL-15Rα and co-receptors IL-2Rβ and IL-2Rγ in neuronal cells. The functions of the cerebral IL-15 system, however, are not yet clear. To test the hypothesis that IL-15Rα regulates metabolic activity and body temperature, we quantified the specific metabolic phenotype of IL-15Rα knockout mice. These normal-appearing mice were leaner with lower fat composition. During the entire circadian cycle, the knockout mice had a significantly higher | [
-0.01946481,
0.000019726878,
-0.007795118,
-0.033203132,
-0.013140717,
-0.004038751,
-0.01120343,
-0.012963406,
-0.025046824,
-0.014880992,
0.00895749,
-0.0040584523,
0.00081472774,
0.012313265,
-0.009036295,
-0.022117909,
0.036250252,
0.005296346,
0.014316224,
0.025335776,
-0.025742933,
0.007985563,
0.014946663,
-0.0044032237,
-0.001810871,
0.0003648831,
0.0011278951,
-0.050119914,
0.00083607074,
-0.022459397,
0.016404552,
-0.009528826,
-0.015038601,
0.017074395,
-0.0017878861,
-0.003579056,
0.009804643,
-0.017415883,
0.0028730952,
0.0067903553,
0.03598757,
-0.0012559531,
0.0139747355,
-0.0017156483,
0.00058529055,
0.002520115,
0.019057652,
-0.028606178,
-0.0033196565,
0.022932226,
0.020568078,
0.013101314,
-0.01683798,
-0.0066458797,
-0.037458595,
0.002355938,
0.015852919,
0.0044327755,
0.01576098,
-0.030944057,
-0.008622569,
-0.019609286,
-0.02063375,
0.012175357,
0.031311814,
-0.00931868,
-0.0016844547,
0.030313618,
0.001228043,
-0.0062879743,
0.02750291,
0.026819933,
-0.020502407,
0.0013232656,
0.0066458797,
-0.013777724,
-0.027266495,
0.007854221,
-0.002505339,
-0.0016261719,
0.02494175,
-0.026701726,
-0.01104582,
0.010159265,
0.019005114,
-0.0053127636,
-0.023588933,
0.018900042,
-0.005033663,
-0.007289453,
0.0114529785,
-0.019583017,
0.017809907,
0.04279106,
-0.028632447,
0.015642773,
0.004015766,
0.017928114,
-0.014828456,
-0.017599761,
-0.0017254989,
0.0039796475,
-0.007598106,
-0.018952578,
-0.028763788,
-0.017350212,
-0.005962904,
-0.0014759501,
0.026727995,
-0.00058118615,
0.0017452001,
0.053744942,
0.014552638,
-0.058946066,
0.011551484,
-0.0018092291,
0.008937789,
0.0055458946,
-0.019911371,
-0.0016696788,
0.022367457,
0.01939914,
-0.0005729773,
-0.003421446,
0.014789052,
0.017429017,
0.0070596053,
-0.008530631,
-0.044235818,
-0.011597455,
-0.016864248,
-0.028684983,
0.016798578,
0.015419492,
-0.024350714,
0.017770505,
-0.013830259,
0.0020325098,
-0.02063375,
-0.013790857,
-0.00884585,
0.010251204,
-0.019740628,
0.01604993,
-0.0018141544,
0.01946481,
0.014854724,
0.0065342397,
0.0015202778,
0.0014931887,
-0.0141717475,
-0.024193104,
0.025900543,
0.006974234,
0.011334771,
0.02639964,
-0.010829107,
0.042817328,
-0.0032063744,
-0.021277323,
0.009141368,
-0.027870666,
-0.0068954285,
0.0052273916,
0.015156809,
0.010724033,
0.016916785,
0.007598106,
0.02456086,
-0.01861109,
-0.0031045848,
0.036644276,
-0.025677264,
0.023917288,
-0.0230373,
0.022025969,
0.010106728,
0.0037859187,
-0.0063142427,
-0.01164999,
-0.004895754,
0.024376983,
0.0037957693,
-0.0043145684,
-0.00025898902,
0.0068034898,
0.021054043,
-0.0058151446,
0.007598106,
-0.017074395,
0.015091138,
0.016102469,
-0.008005264,
-0.03167957,
-0.632961,
-0.013488772,
-0.0030405556,
0.0025217568,
-0.00799213,
0.024902347,
0.0055130594,
-0.013193253,
0.003868007,
0.030208545,
0.017429017,
0.002313252,
0.013429668,
-0.043395232,
-0.034516547,
-0.030681374,
-0.015078004,
-0.017809907,
-0.0109867165,
0.0067969225,
-0.005273361,
-0.011413576,
-0.004275166,
0.011715662,
-0.0007658851,
0.01809886,
0.022722078,
-0.010481051,
-0.0143687595,
0.029840788,
-0.023694007,
0.025782336,
-0.00012703186,
-0.015419492,
0.057580113,
-0.01216879,
-0.0059103672,
0.0423445,
0.0010589408,
0.033728495,
-0.029394228,
-0.016273212,
0.026741128,
0.010999851,
-0.040873475,
0.019871969,
-0.007683478,
0.029761983,
0.001945496,
-0.020883298,
0.017205736,
-0.0018305721,
-0.013212955,
0.0015350537,
-0.0026432476,
-0.008694807,
0.012214759,
-0.0016425896,
0.012247595,
0.016220676,
-0.017875578,
0.02063375,
0.007177813,
-0.01569531,
-0.0138039915,
0.025493385,
0.004386806,
-0.014999199,
0.00065424485,
0.015682176,
0.017468419,
0.031732105,
0.013580711,
0.015721578,
0.02341819,
0.008767045,
0.016010528,
0.021737019,
0.0019701226,
0.010172399,
-0.007736014,
-0.0085766,
-0.020751957,
-0.02016092,
0.011912674,
-0.016535895,
-0.005168288,
0.016286345,
-0.008392721,
0.01820393,
0.018886907,
0.001469383,
-0.026714861,
-0.036355328,
-0.024363847,
0.03133808,
-0.005345599,
0.020883298,
0.016680371,
-0.00761124,
0.0036939797,
0.010559857,
0.008839283,
0.0058020107,
0.01993764,
0.0026941425,
-0.044393428,
-0.002684292,
0.03152196,
-0.02025286,
-0.0113544725,
-0.0028090663,
-0.01185357,
-0.0028993636,
0.01012643,
-0.01924153,
0.018755566,
-0.011124625,
0.008734209,
-0.023510128,
0.020804493,
0.0025611592,
0.020436738,
-0.010146131,
0.01728454,
0.007683478,
0.00016068811,
-0.0068297577,
-0.009837478,
-0.022196714,
-0.0021474336,
0.013869662,
0.015314419,
-0.026925007,
0.016654102,
0.017993785,
0.031416886,
-0.022669543,
0.0027926485,
-0.030339886,
-0.032362547,
-0.024705335,
0.009548527,
-0.0017140065,
-0.0023231027,
-0.0023083268,
-0.012293564,
0.0037103973,
0.007630941,
0.019372871,
-0.00799213,
0.0026202628,
-0.012116253,
-0.002477429,
0.007368258,
-0.01645709,
-0.010921045,
-0.012536546,
-0.0023362369,
-0.0058512636,
-0.0048038154,
0.015721578,
0.0029207065,
0.019097054,
-0.031311814,
-0.018952578,
0.009167637,
0.008379588,
-0.0015358747,
-0.04244957,
-0.014986065,
0.011827302,
-0.020489274,
0.005201123,
0.010527021,
-0.008064368,
0.00011830996,
-0.022853421,
0.007039904,
0.00068954285,
0.0048891874,
0.010257771,
-0.014513236,
-0.009640466,
0.02139553,
0.011630289,
0.03354462,
0.030523764,
0.00038561044,
0.028080812,
-0.012700723,
0.03801023,
0.0012321474,
0.022774616,
0.028658714,
-0.019990176,
0.008162874,
0.002490563,
-0.001604829,
0.013193253,
0.0008537197,
-0.026228897,
0.0052273916,
-0.018978847,
0.017205736,
-0.03136435,
0.007440496,
-0.014224284,
0.012733558,
-0.0057035047,
0.009614198,
0.00904943,
-0.007447063,
-0.0059727547,
-0.010041057,
0.01544576,
-0.021067176,
0.0023871318,
0.0034477143,
-0.042081814,
0.008097203,
-0.0020243009,
-0.011925808,
-0.012418339,
-0.0042488975,
0.017034993,
0.01645709,
0.011768199,
-0.0013602054,
-0.0076572094,
0.00031008906,
0.012792662,
-0.005401419,
0.004275166,
-0.006113947,
0.0063897637,
-0.019438542,
-0.02332625,
0.019320335,
0.024390116,
0.024587128,
0.005132169,
0.012602217,
-0.02263014,
-0.00878018,
-0.0003960767,
0.012569382,
0.018965712,
-0.004422925,
0.03785262,
-0.0032030907,
0.019832566,
-0.014697114,
0.02557219,
0.012746693,
0.0037957693,
-0.007433929,
-0.0001498114,
0.03921857,
0.029289154,
0.011282234,
-0.0067017,
-0.014736516,
-0.01699559,
0.003720248,
0.009128234,
0.0018699745,
-0.00012446659,
0.0005163363,
-0.007013636,
-0.02649158,
0.007466764,
-0.0019963908,
-0.030655107,
0.025046824,
0.014289955,
0.041162424,
0.010343143,
0.017678566,
0.023089835,
0.010454783,
-0.02718769,
0.023234311,
0.013298327,
-0.0039074095,
-0.026583519,
-0.039927814,
-0.00029572358,
-0.0022541485,
0.0017731102,
-0.0003328686,
0.023391921,
0.016194407,
0.011840436,
-0.011636857,
0.0053423154,
0.024429519,
-0.025611592,
0.019727493,
-0.00943032,
0.009561661,
0.01513054,
-0.019372871,
-0.020410469,
0.028369764,
0.02478414,
0.0013519966,
-0.010875076,
-0.0057264892,
-0.00837302,
0.020962102,
0.0010441649,
0.009377783,
-0.026412776,
0.0030914505,
-0.0013109524,
0.017836176,
0.015051736,
0.018335273,
-0.016719773,
-0.030313618,
-0.04617967,
-0.022025969,
-0.020042712,
0.014316224,
0.024889214,
0.0064620017,
0.018295871,
0.0066787153,
-0.0065900595,
-0.023352519,
-0.018742431,
0.013593845,
-0.024757873,
-0.02440325,
0.005224108,
0.003874574,
0.0064849863,
-0.00055820134,
-0.010678064,
0.016417688,
-0.025007421,
-0.015682176,
0.0072040814,
0.023378788,
0.014092943,
0.008596301,
0.0284223,
0.022590738,
-0.0015202778,
0.0053850017,
0.014880992,
0.014999199,
-0.041950475,
0.005063215,
0.014434431,
-0.003854873,
-0.0002092229,
-0.005381718,
0.0005487612,
-0.0086094355,
-0.0025233985,
0.017297676,
0.008740777,
0.027818128,
0.018703029,
0.012786095,
0.007978996,
-0.0048399344,
-0.016168138,
-0.013764589,
0.018151395,
-0.0005984247,
-0.0075784046,
0.022984762,
-0.000282179,
-0.01620754,
-0.014132345,
0.002449519,
0.013751455,
-0.0042193457,
-0.009633899,
0.01066493,
-0.0003074212,
-0.0035462205,
-0.022196714,
0.0130684795,
0.0009497632,
-0.021093445,
-0.013278626,
0.034332667,
-0.006445584,
-0.016851114,
0.0005196198,
0.010612393,
-0.02025286,
-0.0059005166,
0.012411771,
0.014815321,
0.0037366657,
0.012937138,
-0.017363345,
0.006310959,
0.0042291963,
-0.0268068,
-0.0023247446,
0.0132392235,
-0.027371569,
0.015419492,
-0.0012222969,
0.005565596,
-0.030523764,
-0.019438542,
-0.008261381,
0.0053620166,
-0.010218369,
0.029131545,
0.001008046,
-0.00729602,
0.020265993,
0.008018399,
0.016023662,
-0.00193072,
-0.03425386,
0.000055204473,
-0.008451825,
-0.019228395,
0.0071318434,
-0.019070785,
0.0022114625,
0.003726815,
0.0030208544,
-0.019083919,
-0.0075061666,
0.027765593,
-0.011866705,
0.011026119,
0.01313415,
0.013685784,
0.019162724,
0.018532285,
0.006993935,
0.035278328,
-0.013061912,
-0.008550332,
-0.019674957,
0.012385503,
0.0025578756,
-0.012451174,
-0.0054999255,
-0.0010515528,
-0.00080036226,
-0.0030421976,
0.0032112997,
0.01228043,
0.01939914,
-0.008399289,
-0.034805495,
-0.041897938,
-0.0054966416,
-0.021973433,
0.018781833,
-0.003342641,
0.0018995265,
-0.02301103,
0.0015202778,
-0.015235614,
-0.005805294,
0.017547224,
-0.029604373,
-0.014933528,
0.0086094355,
0.0029141395,
0.0028320511,
-0.021789555,
-0.00038950963,
-0.028632447,
-0.009469722,
-0.007414228,
-0.027108885,
0.029709447,
-0.016640969,
0.051827356,
0.011998046,
0.025966214,
-0.010855375,
0.0160762,
0.020646883,
-0.0061008125,
0.0057330565,
-0.000887376,
0.007736014,
-0.024968019,
0.0068034898,
0.014959796,
-0.0051945564,
0.012195058,
-0.017809907,
-0.016864248,
0.021106578,
-0.0067640874,
-0.022117909,
0.0001293919,
-0.025926812,
-0.016312614,
0.03680189,
-0.020870164,
0.0009768524,
-0.014697114,
-0.012083418,
0.039008424,
-0.004820233,
0.019911371,
0.006182901,
0.015892321,
-0.048359938,
0.012352668,
-0.0052076904,
0.01993764,
-0.0063897637,
-0.007368258,
0.02664919,
0.011104924,
0.012917437,
0.004813666,
-0.0060318583,
0.0060745445,
-0.0032408515,
0.010297174,
-0.012037449,
-0.016982457,
0.0022114625,
-0.027870666,
0.013298327,
-0.027397837,
-0.012444607,
-0.0059005166,
-0.034674156,
0.005335748,
0.0098112095,
-0.018125126,
0.024232507,
-0.014670845,
-0.008320484,
0.04294867,
-0.00093498727,
0.019280933,
-0.018414078,
0.04368418,
0.0045312815,
0.016890517,
-0.015511431,
-0.02247253,
-0.007105575,
0.018217066,
0.0407684,
0.022393726,
0.0038351717,
-0.022301786,
-0.0014718457,
0.0023674306,
-0.0068494594,
-0.036539204,
0.01737648,
-0.006517822,
0.0117222285,
-0.022314921,
-0.029735716,
-0.002953542,
0.007197514,
-0.009528826,
-0.0028172752,
-0.00026411953,
0.010093594,
-0.0076440754,
0.03567235,
0.0055754464,
0.011630289,
-0.0091742035,
0.009673301,
-0.0037432327,
-0.0092727095,
-0.025217569,
0.014500101,
0.02750291,
0.029131545,
-0.012851765,
0.02155314,
0.0039008425,
-0.00023313116,
0.0070530386,
0.00037863292,
-0.019766895,
0.03598757,
-0.011321637,
-0.0033229399,
0.013817126,
0.006685282,
0.0251913,
-0.01620754,
0.00033040595,
-0.010100162,
-0.02276148,
-0.007683478,
0.020568078,
-0.0029404077,
-0.031469423,
0.01674604,
-0.036276523,
0.00734199,
-0.035041913,
-0.023759676,
-0.012372369,
-0.034490276,
0.03462162,
-0.005250376,
0.0015153525,
0.0068757273,
0.025178166,
-0.007788551,
-0.00461337,
0.014486968,
-0.04389433,
0.019031383,
-0.008366453,
-0.0014751292,
0.00034189833,
-0.0025233985,
-0.0058808154,
-0.008616002,
0.029761983,
-0.0083401855,
-0.023772812,
-0.012726991,
0.004380239,
0.019070785,
-0.0022065372,
-0.0041635255,
0.019333469,
0.012142521,
-0.002464295,
0.0036151747,
-0.0118207345,
0.00707274,
-0.034437742,
-0.010947314,
0.022328055,
0.0041930773,
-0.013751455,
0.013206388,
0.016023662,
0.005273361,
-0.0075193006,
-0.008714508,
0.0006505509,
0.020817628,
-0.001199312,
0.016522761,
-0.0005175676,
0.002846827,
-0.04063706,
0.020055847,
0.0053554494,
-0.027555447,
-0.011663125,
0.013738321,
-0.010999851,
0.033019252,
-0.02247253,
0.0010991641,
0.0048399344,
-0.028448569,
-0.05395509,
-0.003884425,
-0.000020073188,
0.027949471,
0.007795118,
-0.008392721,
-0.028080812,
0.002470862,
-0.049647085,
-0.015971126,
0.007781984,
-0.006097529,
-0.0057035047,
0.0097127035,
-0.008176008,
0.01566904,
-0.015511431,
0.021093445,
-0.013843394,
-0.018703029,
0.0010392396,
-0.00083114544,
0.0026892172,
0.014473833,
-0.0005163363,
-0.022236116,
0.033098057,
-0.020660019,
-0.023247445,
0.042213157,
-0.02079136,
0.010284039,
-0.009909716,
0.02000331,
-0.016522761,
0.019280933,
0.025230702,
-0.016470224,
0.0005110005,
0.0041503916,
-0.0156165045,
0.0033984613,
0.0021326577,
0.0044524767,
0.024508324,
0.0021983283,
-0.013114449,
-0.02750291,
0.004051885,
-0.008176008,
0.036250252,
0.0073551238,
0.00089886837,
0.008359887,
-0.015327553,
-0.012832064,
0.0025463833,
-0.014303089,
-0.0062715565,
-0.00007511092,
0.015682176,
0.008990326,
-0.012103119,
0.022577604,
0.01566904,
-0.02278775,
0.0069019957,
0.0020768375,
0.012339534,
-0.0073222886,
-0.008018399,
0.008057801,
-0.025204433,
-0.013909064,
0.0107306,
-0.0040650195,
-0.016929919,
0.006993935,
0.0020998223,
-0.013324595,
-0.0138039915,
0.020817628,
-0.016338883,
-0.006530956,
-0.0198457,
-0.021894628,
-0.02000331,
0.012221326,
0.18965712,
-0.018597957,
0.00931868,
0.01367265,
-0.012786095,
0.0061796177,
-0.0001381138,
-0.013409967,
-0.011039253,
0.0061861845,
0.013909064,
0.0034345803,
-0.020988371,
0.0038515895,
-0.0013495339,
-0.001313415,
-0.022984762,
0.0109867165,
-0.021040907,
-0.0125299785,
0.015406358,
-0.0010252845,
0.016089333,
-0.016562164,
0.021605676,
0.01674604,
-0.019793164,
0.005907084,
0.035041913,
0.0042423303,
-0.033754766,
0.027765593,
-0.0090034595,
0.011748497,
0.00772288,
0.0009218531,
-0.018689895,
0.0030701074,
0.008313917,
-0.0048563518,
-0.0019848985,
-0.010513887,
0.0049581416,
-0.0047709798,
-0.008753911,
0.014079808,
0.003477266,
0.0013380415,
0.0034148789,
0.011630289,
-0.03456908,
0.0004321956,
0.03956006,
0.046521157,
0.0056312666,
0.0063503613,
0.023825347,
0.027555447,
0.008786746,
0.017087528,
-0.008701374,
0.010651795,
-0.0230373,
0.034017447,
-0.011643424,
0.038220376,
-0.033570886,
-0.012516845,
-0.0032704032,
0.005870965,
0.004961425,
-0.010960448,
-0.01807259,
-0.013160418,
0.001590053,
-0.0068822945,
0.026281433,
0.026163226,
-0.0033656259,
0.010041057,
0.011282234,
0.019924505,
-0.010724033,
0.018558554,
-0.019438542,
-0.0051091844,
0.023904152,
0.017258273,
-0.03772128,
-0.023378788,
0.01658843,
-0.006622895,
-0.015839785,
0.0024281759,
0.0024248925,
-0.031600766,
-0.020371066,
-0.011209997,
-0.010973582,
-0.00063864805,
-0.026504714,
0.06913816,
0.011689394,
0.013160418,
-0.0018502733,
-0.0053850017,
0.0034575649,
0.008616002,
0.0018913175,
-0.0040059155,
0.014158614,
-0.037090838,
0.004216062,
0.005559029,
-0.021027774,
0.021027774,
-0.0048399344,
-0.039743938,
0.0023378786,
-0.005585297,
-0.0182302,
-0.0040978547,
-0.005430971,
0.04000662,
-0.017061261,
0.011479247,
-0.012635052,
0.0026399642,
-0.0010958806,
-0.016089333,
-0.0015449044,
-0.010901344,
-0.010454783,
0.02487608,
0.016391419,
-0.006468569,
0.018400945,
-0.00025036972,
-0.0020637033,
0.024771007,
-0.019451676,
-0.011715662,
0.011072088,
-0.009561661,
0.018913176,
-0.0027138437,
0.024534592,
0.025138764,
-0.02487608,
0.002513548,
-0.018624224,
-0.0358825,
-0.014289955,
-0.01971436,
0.032388814,
-0.013318028,
-0.0241143,
-0.042108085,
-0.0009891656,
0.016155005,
-0.024587128,
0.006379913,
-0.0006759983,
-0.025834873,
-0.015590236,
-0.0037892023,
-0.16422941,
0.009679869,
0.021776421,
-0.03564608,
0.016391419,
0.01636515,
-0.016877383,
-0.012983107,
-0.0048662024,
0.005004111,
0.02934169,
-0.011012984,
-0.026097557,
0.003713681,
-0.0070661725,
-0.004629788,
-0.0055688797,
0.037195913,
0.022932226,
0.02240686,
0.042081814,
-0.030523764,
-0.0016475149,
-0.0016442314,
0.0059826053,
0.0141717475,
-0.010533588,
-0.021237921,
0.020568078,
-0.025362043,
-0.009482856,
0.0033212982,
0.03942872,
0.019320335,
0.03942872,
-0.012516845,
0.01243804,
-0.0030832416,
-0.024981152,
0.016522761,
0.038246643,
0.011374174,
-0.0053784344,
0.032861643,
-0.012904302,
0.034884304,
0.008077502,
0.01066493,
0.012195058,
-0.024928616,
0.008760478,
-0.026819933,
0.0059103672,
0.01582665,
0.040715866,
0.01683798,
0.0063240933,
0.026281433,
-0.005099334,
-0.009896582,
-0.0045312815,
-0.022511933,
0.028501105,
-0.0035265193,
0.024757873,
-0.0013716978,
0.004734861,
0.009029728,
-0.0016146796,
0.00884585,
-0.031627033,
-0.012286997,
-0.000324865,
-0.02332625,
0.000340667,
0.026504714,
0.012792662,
0.015025468,
0.020646883,
0.011630289,
-0.010297174,
0.00082950364,
-0.044314623,
-0.009312112,
-0.032047324,
-0.009502557,
0.032493886,
0.038666938,
-0.013462503,
0.00032363366,
0.010835674,
-0.013948468,
0.010494186,
-0.026583519,
0.025046824,
0.014552638,
0.016378285,
-0.0028222005,
0.010684631,
0.0009842403,
0.0063864803,
-0.03921857,
-0.0049023214,
-0.0022492232,
0.0075193006,
-0.015472028,
-0.042318232,
-0.00810377,
0.018703029,
-0.0058840993,
-0.0031866732,
-0.02678053,
-0.0007178634,
0.023785945,
-0.013777724,
0.011072088,
-0.01784931,
-0.016312614,
0.020292262,
-0.03291418,
0.06209826,
0.022117909,
-0.0042127785,
0.019569883,
-0.012786095,
-0.042108085,
-0.13585965,
-0.032520156,
0.0034904003,
0.0028501104,
-0.0065966267,
0.017363345,
-0.004997544,
0.031311814,
-0.018558554,
0.007466764,
-0.038509328,
0.012812363,
0.00509605,
-0.005181422,
-0.0077557154,
0.0027450374,
0.027739324,
-0.007368258,
-0.01712693,
0.04187167,
0.0067312517,
-0.019188993,
0.002137583,
-0.009647033,
-0.0023625053,
-0.0061073797,
-0.03848306,
0.00461337,
0.006333944,
0.00070678146,
0.02130359,
0.0018486315,
0.015301284,
-0.0086357035,
-0.0008561824,
-0.012871467,
-0.0004551804,
-0.0257298,
0.023181774,
-0.009935984,
-0.00054917164,
0.0068166237,
0.007368258,
0.0012534905,
0.0018502733,
0.011328205,
-0.0021572842,
-0.0044820285,
0.01863736,
-0.0338073,
-0.017100664,
-0.020686286,
-0.016785443,
-0.014644577,
0.022643274,
-0.0030192127,
0.017875578,
0.014815321,
-0.022997897,
-0.003038914,
0.010783137,
0.016378285,
-0.026714861,
0.0063240933,
0.023286847,
-0.02516503,
-0.02481041,
-0.0391135,
0.02265641,
-0.018414078,
0.006445584,
0.0160762,
-0.0056805196,
-0.02047614,
-0.018020054,
0.0007297662,
-0.0010236428,
-0.0071318434,
-0.00066984165,
-0.0000066376197,
-0.04218689,
-0.017980652,
0.004393373,
-0.008110338,
0.010231502,
0.0021310158,
-0.008556899,
-0.0064357333,
-0.008773612,
-0.0019569884,
-0.0070596053,
0.025270104,
0.026045019,
-0.009660168,
-0.0110589545,
0.008530631,
-0.0033245818,
-0.02532264,
0.02981452,
0.01971436,
-0.02006898,
-0.044393428,
-0.04263345,
0.010356277,
-0.020712554,
-0.021645078,
0.00030229066,
-0.022800883,
0.0024954884,
-0.017744236,
-0.0045903856,
0.011282234,
-0.022774616,
0.013429668,
-0.005283212,
-0.010500752,
-0.020948969,
-0.025230702,
0.016273212,
0.0044524767,
0.019963907,
0.012536546,
-0.0026547401,
-0.0054473886,
-0.0045871018,
-0.007847655,
-0.022275519,
-0.0068100565,
-0.014972931,
0.024508324,
0.0053915684,
-0.011137759,
-0.0010039415,
-0.05022499,
-0.008294215,
0.009141368,
-0.012037449,
-0.024166835,
-0.012411771,
0.034069985,
0.021421798,
0.028002007,
-0.016325748,
-0.020962102,
0.021251054,
-0.01405354,
0.002703993,
0.002186836,
-0.023221176,
0.007978996,
-0.0075061666,
-0.0061533493,
0.028973935,
0.016443955,
0.002889513,
-0.036644276,
-0.0022541485,
0.028921397,
-0.0053127636,
-0.0076046726,
-0.014736516,
-0.0107174665,
0.022131043,
0.02265641,
0.020883298,
0.0069610993,
0.006537523,
-0.008865551,
-0.020817628,
0.01158432,
0.0031357782,
-0.007433929,
-0.037668742,
-0.012602217,
0.021277323,
0.0010113296,
0.0182302,
-0.011873271,
-0.011801033,
-0.0035692053,
0.0019766896,
0.017061261,
0.020502407,
-0.00028833564,
-0.034884304,
0.0012132671,
0.023720274,
0.0010417022,
-0.017271407,
0.025125628,
-0.004793965,
0.00037227105,
0.014670845,
-0.008202276,
0.019215262,
0.0032195086,
0.025848007,
0.01820393,
-0.01490726,
-0.01899198,
-0.0062945415,
0.034516547,
0.002257432,
-0.011032686,
0.0114529785,
-0.024797276,
-0.0024314595,
-0.0030602568,
-0.023641469,
-0.01683798,
-0.018138262,
-0.010592692,
0.016811712,
0.01863736,
-0.0023510128,
0.01474965,
-0.022722078,
0.012516845,
-0.02889513,
0.009154502,
-0.027292764,
0.030208545,
0.023772812,
-0.007125276,
0.011407009,
-0.00788049,
0.00013462504,
-0.008885252,
0.027607983,
-0.013442802,
0.007512734,
-0.0035232357,
0.024849812,
-0.013528175,
-0.038089033,
-0.012418339,
-0.011643424,
0.0039927815,
0.0007859968,
0.015734712,
-0.0034378637,
0.08936475,
-0.0057035047,
-0.025624726,
0.0067312517,
-0.008044667,
0.010835674,
-0.0055327606,
0.030838983,
-0.025821738,
-0.020948969,
0.023234311,
-0.021408664,
0.043290157,
-0.061520357,
-0.03906096,
0.0044688946,
0.0054112696,
-0.002932199,
0.0061664833,
-0.026793666,
0.01728454,
0.0049253064,
0.0026530982,
0.013620113,
-0.04575938,
0.0016770668,
0.057580113,
-0.01474965,
-0.0033098059,
-0.034227595,
0.013725187,
0.005453956,
-0.051249452,
-0.003088167,
0.015314419,
-0.03506818,
0.010829107,
-0.007394526,
0.011026119,
0.03104913,
-0.0018831088,
0.011958644,
-0.022525067,
-0.037327252,
-0.0043703886,
-0.015577102,
-0.020581212,
-0.005742907,
-0.0369595
] |
OBJECTIVE To compare the outcome of pregnancy in cohorts of women with singleton pregnancy and history of preterm birth and sonographic short cervix managed with different treatment protocols, namely cerclage, vaginal progesterone or cervical pessary. METHODS This was a comparison of three management protocols for women with singleton pregnancy and a high risk of preterm birth because of a prior spontaneous preterm birth before 34 weeks and a shortened cervical length detected by transvaginal ultrasound. The study included 142 women who were initially treated with cerclage (USA), 59 with vaginal progesterone (UK) and 42 with cervical p | [
-0.0048144045,
-0.0038522084,
0.008697431,
-0.03218734,
-0.0024448682,
0.021613456,
0.009498689,
0.022928344,
-0.02832486,
-0.020640988,
-0.007930413,
0.01954525,
-0.016983958,
0.025982717,
0.011108057,
0.01184768,
0.029913682,
-0.012511972,
0.008375557,
-0.0029071332,
-0.016942868,
0.010642367,
-0.023092704,
0.017723583,
-0.0008153841,
-0.024489772,
0.017162016,
-0.014176127,
0.0063724085,
-0.0030577974,
-0.011902467,
0.01025201,
-0.0135940155,
-0.017244197,
-0.037309922,
-0.015258169,
-0.0057971454,
0.0066292225,
-0.00012241463,
0.00088772003,
0.02668125,
0.0036741507,
-0.008526221,
0.009169968,
-0.010834122,
-0.011539504,
-0.019969847,
0.00037815844,
-0.013340625,
-0.007909868,
0.016559359,
0.010341039,
-0.019613734,
0.047500297,
-0.022531139,
0.0045712874,
-0.015874522,
0.019134346,
0.006173806,
-0.043583028,
-0.016038883,
0.014956841,
-0.026201865,
0.010005469,
-0.0010700579,
0.012518821,
-0.017792067,
0.020010939,
-0.013361171,
0.0006621518,
0.02832486,
0.044569194,
0.0012703727,
-0.003752907,
0.0168059,
-0.017504435,
-0.02887273,
0.00857416,
0.012518821,
0.025790963,
0.004971917,
0.0059272647,
0.0008954244,
0.016696326,
-0.017298983,
0.0009579158,
-0.014258307,
0.026763432,
-0.020558808,
-0.018641263,
0.022805072,
0.022599623,
0.006303925,
0.027420875,
0.0004605529,
0.028982304,
0.008642644,
0.035145838,
0.0014912327,
-0.008197499,
0.0073619983,
-0.010450613,
-0.0021657972,
-0.016189547,
-0.015326653,
-0.012224341,
-0.00015141319,
-0.003571425,
0.026407316,
-0.02050402,
-0.0154362265,
0.018148182,
-0.00089371233,
-0.012443488,
0.019353494,
-0.012306522,
0.009039849,
-0.0028951485,
-0.024147354,
0.008567311,
0.019928757,
-0.014902053,
0.043226913,
-0.036625084,
0.022490049,
0.013162568,
-0.04273383,
0.001090603,
0.022846164,
-0.011669623,
-0.0032855056,
0.026037505,
0.0105807325,
0.003883026,
0.0015699889,
0.0012900617,
-0.012279128,
-0.017833157,
-0.020709472,
-0.03155729,
0.010012317,
0.021312129,
-0.0011821999,
0.011649078,
-0.013176264,
0.007526359,
0.024708921,
0.021859998,
-0.012046283,
0.0117655005,
-0.006488831,
-0.018093394,
-0.0028181043,
-0.0038590566,
0.008717976,
0.009156271,
0.010601277,
0.018298846,
-0.031365536,
-0.031365536,
-0.017970124,
0.024065174,
-0.0033163233,
0.017244197,
-0.004122719,
0.015449923,
0.0027753022,
-0.0023524151,
0.011772349,
-0.020024635,
-0.016655236,
0.006468286,
-0.03076288,
0.00062020554,
-0.018750837,
0.007937261,
-0.03248867,
0.0294206,
-0.0077181133,
-0.047335938,
-0.05185586,
0.005940961,
0.021120375,
0.022572229,
-0.0281605,
0.016394999,
0.014545939,
-0.009074091,
0.010991635,
-0.0045610145,
0.011443627,
-0.0025972445,
-0.03163947,
-0.003145114,
-0.63728195,
-0.035611525,
-0.0024140505,
-0.0006981057,
0.0073619983,
0.025832053,
0.0066497675,
-0.0035680009,
-0.013340625,
0.025078733,
-0.01042322,
0.029721927,
-0.009786321,
0.015682768,
-0.009717838,
-0.008355012,
-0.0017309256,
0.0011881923,
-0.004526773,
-0.022435261,
-0.023476213,
0.020558808,
0.0072181826,
0.034269243,
0.031612076,
0.02655798,
0.009005607,
-0.017915336,
-0.02273659,
0.010375281,
-0.011416233,
0.017285287,
-0.023352943,
-0.0039446615,
0.047938593,
-0.012251735,
-0.015162292,
0.015285563,
0.0064785583,
0.025900537,
-0.04900694,
-0.0072798175,
-0.0000701958,
-0.00920421,
-0.0087933075,
0.015901916,
0.010128739,
-0.0130119035,
0.007040125,
0.013559774,
0.026366226,
-0.0017891368,
-0.0015049294,
0.010313646,
-0.0075537525,
-0.0032718088,
0.038789168,
-0.02159976,
-0.007827687,
-0.013326929,
-0.008218044,
-0.0011770637,
0.01605258,
-0.014902053,
-0.0053965156,
0.016819598,
-0.0065401937,
-0.00073363166,
-0.0055026654,
-0.0136008635,
0.0043795328,
0.049308266,
0.0031656593,
-0.019860273,
0.0041364157,
0.00743733,
0.01223119,
0.008108471,
0.00026730046,
0.00053888117,
0.0041569606,
-0.011060118,
-0.017079836,
0.021462793,
0.015901916,
-0.0049582203,
-0.026270349,
0.02411996,
0.0039138435,
-0.00773181,
-0.007882474,
0.010731396,
-0.0019398009,
-0.010868364,
0.0037700278,
0.022298293,
0.009847957,
0.003146826,
0.01546362,
-0.009526083,
-0.015449923,
-0.01424461,
-0.003441306,
0.021942178,
-0.0010238313,
0.005766328,
-0.01828515,
-0.0032803693,
0.034488395,
-0.028215285,
0.016586753,
0.0030458127,
0.016038883,
0.00045755674,
0.011457324,
-0.027681112,
-0.0044514406,
0.014052856,
-0.0010409523,
-0.02003833,
0.019969847,
-0.0081564095,
-0.0009930137,
0.01349129,
-0.00020962434,
0.0069442475,
0.00069082936,
0.0019124075,
0.01962743,
-0.004721951,
-0.0030423885,
0.0021127223,
0.020188997,
-0.0068689156,
0.029146664,
-0.0022171598,
0.027544146,
-0.0010769062,
0.0023455669,
-0.0184906,
-0.0032820816,
-0.00987535,
-0.005030128,
-0.0072798175,
0.0056738746,
-0.042816013,
-0.0065744356,
0.0008042555,
-0.0068346737,
0.0035577284,
0.00521161,
-0.030351978,
0.0065436177,
-0.009690444,
-0.015477317,
-0.0077386587,
-0.037035987,
-0.05067794,
-0.023503607,
-0.035036262,
0.015271866,
0.028598795,
-0.03676205,
-0.0073825433,
0.004865767,
-0.027681112,
0.0028609068,
-0.009745231,
-0.009484993,
-0.01475139,
-0.0025065036,
-0.008553615,
0.010745093,
0.014039159,
-0.013861101,
0.022243507,
-0.00009657272,
-0.020586202,
-0.013689892,
0.01062867,
-0.0033591257,
-0.008334466,
-0.012806453,
0.0015785494,
0.018107092,
0.00853307,
0.008382405,
-0.009183665,
-0.010512249,
0.020216389,
0.0005243284,
0.0046329224,
-0.0022993404,
0.040405385,
-0.009060394,
-0.012662637,
-0.002145252,
0.009752079,
-0.01840842,
0.028544007,
0.04089847,
0.0014261731,
0.030516338,
-0.018764535,
0.016422393,
-0.010162981,
0.016668933,
-0.004718527,
0.0281605,
-0.0052766693,
-0.009676747,
0.018079698,
-0.00739624,
-0.02466783,
-0.023010524,
0.028817942,
0.0057800245,
-0.005824539,
-0.012012041,
0.021901088,
0.007998897,
-0.021503882,
0.024695223,
0.019695913,
-0.03594025,
0.033118717,
-0.007882474,
-0.003920692,
0.016367605,
-0.0136145605,
-0.019312404,
0.028735762,
0.018175574,
-0.0015477317,
0.019106952,
0.03854263,
0.037830397,
-0.024256928,
0.007978352,
0.0025082156,
-0.0072592725,
0.022791376,
0.021038193,
-0.005961506,
0.01016983,
-0.009567173,
0.035392378,
0.019339798,
-0.0010341039,
0.013135174,
0.0058279634,
0.007834536,
-0.024147354,
0.003735786,
0.0038932986,
0.0011821999,
-0.009498689,
0.014997931,
0.013484441,
0.027571538,
0.020161603,
0.014272003,
-0.014641816,
-0.010498552,
0.014997931,
0.015367743,
0.037994757,
-0.0009716125,
-0.008327618,
-0.019778093,
-0.0021349795,
0.0068586427,
-0.0069237025,
0.0029670564,
-0.0022274326,
0.024571953,
0.01786055,
0.0129913585,
0.031036815,
0.0020973135,
-0.014408971,
-0.030488946,
0.023024222,
0.020695776,
-0.020777956,
-0.0081427125,
-0.012505124,
-0.009108333,
-0.00046825732,
0.008259134,
0.0033009145,
0.0020819046,
-0.0032700968,
0.0042596865,
0.003677575,
-0.003883026,
0.005526635,
-0.014093946,
0.007211334,
-0.011340901,
0.024174748,
-0.010834122,
-0.0273113,
-0.010847819,
0.015189686,
0.008348163,
-0.018093394,
-0.05139017,
-0.013052993,
0.009190513,
0.012149009,
-0.023147492,
0.002292492,
0.000092988026,
-0.008813852,
0.0012429792,
-0.00953978,
-0.016353909,
0.015655374,
0.0001275509,
0.002734212,
-0.009601415,
-0.010525946,
-0.018613871,
0.02958496,
0.031338144,
0.027174333,
0.03492669,
0.009710989,
0.0011950406,
-0.0062251687,
-0.028105712,
0.02172303,
0.011717562,
-0.0024089143,
-0.005215034,
0.0077797486,
-0.0111902375,
0.0067045544,
0.020093119,
0.008717976,
-0.013956979,
0.0005328888,
-0.012950269,
0.011484717,
-0.0065264967,
0.035556737,
0.020914923,
-0.0004733936,
-0.019531552,
0.021051891,
0.023887116,
0.0003550452,
0.007848232,
-0.04092586,
0.028598795,
-0.011525807,
0.03667987,
0.0021024498,
-0.0037118166,
0.027640022,
-0.020490324,
0.0024928069,
0.026078595,
0.0111902375,
0.019737003,
0.0021195705,
-0.0017334938,
0.00012369869,
-0.004406926,
0.027475663,
0.0087933075,
0.0010991634,
-0.025243092,
0.03248867,
0.034981474,
0.0006381825,
-0.018627567,
0.02369536,
-0.0015015051,
-0.0142309135,
-0.014943144,
0.009902744,
-0.0052937903,
-0.014395274,
-0.02176412,
-0.0017685917,
-0.0210108,
-0.006290228,
-0.02487328,
-0.024434986,
0.003364262,
-0.022599623,
-0.0074989656,
-0.00979317,
0.010450613,
-0.022161327,
0.019134346,
0.017134622,
0.008711127,
0.016545663,
-0.001109436,
0.008355012,
0.03248867,
-0.023421427,
-0.010354736,
0.0012352748,
-0.01790164,
0.00023220255,
0.019969847,
-0.007930413,
-0.011443627,
-0.03273521,
-0.0010435204,
0.007505814,
-0.008505676,
-0.011738107,
-0.018887805,
0.011936709,
0.017449647,
0.005526635,
0.016285425,
-0.023215976,
-0.020325962,
-0.009505538,
-0.03509105,
0.021408007,
-0.008854942,
-0.005266397,
0.021229949,
-0.00095877185,
-0.0035543041,
-0.011395688,
-0.00084491767,
0.023188582,
-0.016148457,
0.018833019,
0.002090465,
0.021243645,
0.0154362265,
-0.016888082,
0.030625911,
0.052842025,
-0.010334191,
0.00027307877,
0.012909178,
0.03125596,
0.009841108,
-0.027078457,
0.022120235,
0.011135451,
-0.032981753,
-0.037912577,
-0.0124229435,
0.005875902,
0.033255685,
-0.002753045,
-0.009594567,
-0.03673466,
-0.011662775,
-0.019052166,
0.011587443,
-0.02458565,
-0.003276945,
-0.012450337,
0.0065401937,
-0.029064484,
0.0023917933,
0.023572091,
-0.029557567,
-0.011573746,
0.012333915,
-0.02911927,
0.02911927,
0.0036536055,
0.0018182424,
-0.017435951,
-0.016983958,
-0.014614422,
-0.045610145,
-0.008259134,
-0.018107092,
0.028982304,
-0.0055026654,
0.029064484,
-0.002054511,
0.001572557,
0.0054855444,
0.019326102,
0.012895482,
-0.012826998,
0.0077181133,
-0.034981474,
0.02373645,
-0.016381301,
-0.024558255,
0.00013782346,
-0.008930275,
0.015860826,
0.020202693,
-0.025119822,
-0.0060779285,
0.008176954,
-0.02609229,
-0.025982717,
0.008053684,
0.017778369,
0.00018137481,
-0.033913128,
-0.0061806543,
-0.020819046,
0.0035200624,
0.010101346,
-0.0030269797,
0.018901503,
-0.01369674,
-0.0040508113,
-0.020682078,
-0.005961506,
0.006238865,
0.008218044,
-0.009491841,
-0.001201889,
-0.0035851218,
0.012683182,
0.038131725,
0.011025876,
0.0057766004,
-0.032680422,
0.026379922,
-0.018860413,
-0.0076290844,
0.020750562,
-0.027256515,
-0.012340764,
0.012094222,
-0.0066292225,
-0.019024773,
-0.0074304817,
0.010135588,
-0.0014835282,
0.03147511,
-0.015518407,
-0.021120375,
-0.008218044,
-0.027516752,
0.0141898235,
-0.006081353,
0.02655798,
0.00953978,
-0.010231465,
-0.0081632575,
-0.006413499,
0.00019143336,
0.005975203,
0.027448269,
0.027557842,
0.017874246,
-0.023270762,
0.0021555247,
0.028900122,
-0.035501953,
-0.051034056,
0.010690306,
0.013039297,
-0.027982442,
0.0022496898,
-0.01101218,
-0.019764397,
0.0047424966,
-0.007252424,
-0.00030197034,
0.014354184,
-0.0071086083,
0.0063176216,
0.028680975,
-0.045610145,
0.037501674,
0.005916992,
0.012731121,
-0.008731673,
-0.018833019,
-0.0022702347,
0.016312819,
-0.010067104,
0.016614147,
-0.0093685705,
-0.024339108,
0.0010760502,
-0.011279266,
-0.010286252,
-0.0020185572,
-0.011820287,
0.0369812,
0.00035632926,
-0.013799466,
0.028270073,
-0.006920278,
-0.003588546,
-0.028379647,
-0.008581008,
-0.010135588,
0.00573551,
-0.0019654823,
0.037392102,
0.024791101,
-0.0129913585,
-0.019298708,
-0.0022650985,
0.0029995863,
-0.0112176305,
-0.011060118,
-0.015860826,
-0.012525669,
-0.015449923,
-0.0006814129,
-0.014354184,
0.007834536,
-0.0072181826,
-0.00028442137,
-0.0009099772,
0.006584708,
-0.027626326,
0.008129016,
0.0023164612,
-0.024763707,
-0.03163947,
0.0047664656,
-0.026489496,
-0.015764948,
0.009895895,
-0.005208186,
-0.02029857,
-0.011662775,
0.00014317375,
0.018107092,
-0.010971089,
-0.027585236,
0.0029739048,
0.02824268,
0.0056156637,
-0.012792756,
-0.02739348,
0.017490737,
0.020736866,
-0.016614147,
0.010683457,
-0.019065863,
0.00073320366,
-0.030269796,
0.015162292,
0.04224075,
-0.045582753,
0.022722892,
0.0060197175,
0.009902744,
-0.025832053,
-0.00857416,
-0.011334053,
-0.020723168,
-0.022558533,
0.011265569,
0.007005883,
-0.023339245,
-0.0006249138,
-0.0024431562,
-0.02222981,
0.0021161465,
-0.016655236,
-0.0010469446,
-0.003906995,
-0.0099780755,
-0.016340211,
-0.009491841,
-0.013265293,
0.041829847,
0.026147079,
-0.014696603,
-0.04892476,
-0.010662912,
-0.038597416,
-0.001830227,
0.0053040627,
0.015093808,
0.014148734,
0.023709059,
0.022599623,
0.019558946,
-0.002792423,
0.013813163,
-0.03240649,
-0.015901916,
0.0042802314,
-0.0111765405,
0.055663556,
-0.010238314,
-0.036214184,
-0.015271866,
0.009464447,
0.013915889,
0.013648802,
0.03917268,
0.0081838025,
0.028434433,
-0.017723583,
0.004345291,
-0.0052184584,
-0.0018952865,
-0.011025876,
-0.032433882,
0.01088206,
0.003217022,
0.024804797,
-0.01386795,
-0.006252562,
-0.023681665,
-0.023311853,
0.014258307,
-0.009183665,
-0.008437192,
0.014436365,
0.010813577,
-0.010827273,
0.0117928935,
-0.010635519,
0.00840295,
0.020175299,
0.0032598244,
-0.00962196,
0.009964379,
-0.006547042,
-0.0038111182,
0.01046431,
-0.0050746426,
-0.028187891,
0.0017857125,
0.027366089,
-0.010977938,
-0.0021229947,
-0.01105327,
0.005786873,
-0.026188169,
0.016216941,
-0.00184906,
0.019148044,
0.016066277,
-0.0007242152,
-0.01920283,
0.008827549,
-0.009046697,
0.0004198907,
-0.010478007,
0.007916716,
-0.015806038,
-0.018737141,
0.02525679,
0.0049445233,
0.0045747114,
-0.0036809992,
-0.003513214,
0.18638524,
0.02344882,
0.0015605724,
0.015121202,
0.01706614,
-0.0014552787,
0.023133796,
-0.0030372522,
-0.0012866376,
0.01840842,
0.02210654,
-0.010690306,
0.01542253,
-0.0009082651,
0.032461274,
-0.027516752,
-0.012354461,
-0.050951876,
0.009567173,
-0.010745093,
0.00002145466,
-0.0014672633,
0.026845612,
-0.009710989,
0.004598681,
-0.001719797,
-0.016285425,
0.015641678,
0.032351702,
0.019517856,
-0.006026566,
0.01021092,
0.012244886,
0.009252149,
0.010525946,
0.0045233485,
0.014860963,
-0.010875212,
-0.009115181,
-0.033776164,
-0.017285287,
-0.004858919,
-0.015669072,
-0.0024637012,
-0.014587029,
0.024448682,
0.0030355402,
-0.018641263,
0.0016864112,
-0.0011796318,
-0.015901916,
0.029228844,
0.030078042,
-0.004249414,
-0.012628395,
-0.0054992414,
0.029311026,
0.0036741507,
-0.00035718532,
0.011998345,
0.0040782047,
-0.0041912026,
-0.025393758,
0.0071154567,
0.013333777,
0.02340773,
-0.007978352,
-0.022544835,
-0.011560049,
-0.0005080635,
0.008717976,
-0.010772486,
0.000016840037,
0.015271866,
-0.033392653,
-0.028133105,
0.034680147,
0.023476213,
0.023106402,
-0.0015657087,
-0.019380888,
-0.015764948,
-0.014929447,
-0.034515787,
0.008053684,
-0.016490877,
-0.0059272647,
0.02903709,
-0.025147216,
0.025612906,
0.0055540283,
-0.011340901,
-0.034652755,
-0.019189134,
-0.00074561633,
-0.0136077115,
-0.012957117,
0.017805763,
-0.011019028,
0.017997518,
-0.030872453,
0.066620946,
0.028297467,
0.0031536745,
-0.016888082,
0.012443488,
-0.023928206,
0.039693154,
-0.00048067,
-0.018175574,
0.017792067,
0.0077934456,
0.014682906,
-0.022558533,
0.0056088152,
0.013395413,
0.0094096605,
-0.029393205,
0.017093532,
0.00005532199,
-0.0072181826,
-0.028050926,
0.00743733,
0.027681112,
-0.0172305,
-0.034433607,
0.007861929,
0.013128326,
-0.033392653,
-0.014148734,
0.0002568139,
-0.018915199,
0.0070538213,
0.016175851,
0.012881785,
0.007868778,
0.0071839406,
-0.010793031,
0.004896585,
0.035995036,
0.010375281,
0.0081701055,
-0.000086567685,
0.016271727,
-0.0027290755,
0.013730982,
0.0027821504,
0.002864331,
-0.025106126,
0.0029276784,
-0.018545387,
-0.016079973,
0.016367605,
-0.020956013,
0.017614009,
-0.038433053,
-0.009176816,
-0.03500887,
0.00068911724,
0.02403778,
-0.016025187,
-0.005143126,
0.022339383,
-0.016436089,
0.007827687,
0.001294342,
-0.17455126,
0.01832624,
0.011443627,
-0.019380888,
0.019093256,
0.0032581121,
0.019175436,
0.008122168,
-0.04336388,
-0.03429664,
0.013669347,
0.030543732,
-0.03815912,
-0.022928344,
-0.000043043077,
0.017709885,
0.0025065036,
0.0087727625,
0.013683044,
0.020517718,
0.0061669573,
-0.02046293,
0.013778921,
-0.008457737,
0.0093617225,
0.0042459895,
-0.01432679,
0.009101484,
0.01966852,
-0.009183665,
-0.008581008,
0.0057423585,
0.022366777,
0.006711403,
-0.008368708,
-0.016312819,
0.010539642,
0.010457462,
0.03125596,
0.005033552,
0.016696326,
0.00584166,
0.005348577,
-0.003030404,
-0.009957531,
0.023079008,
0.0038967228,
-0.019093256,
0.028434433,
-0.004845222,
0.006214896,
-0.0068038558,
0.010614974,
-0.0071907886,
-0.009943834,
-0.0030047225,
0.0041192947,
-0.0028523463,
0.0024979431,
0.00048195405,
0.015669072,
-0.021462793,
0.008998759,
0.010176678,
-0.011525807,
-0.009416509,
0.008252286,
0.002326734,
-0.022243507,
0.003588546,
-0.025558118,
-0.02454456,
-0.0023592636,
-0.01790164,
0.037638642,
0.021120375,
-0.01588822,
0.039556187,
-0.0016410408,
-0.005488969,
0.0032084615,
0.006081353,
-0.02046293,
-0.015751252,
0.016778508,
0.017887942,
0.006550466,
0.03492669,
-0.009649354,
0.016778508,
0.003439594,
-0.022763982,
0.0019500734,
-0.031749044,
-0.0075332075,
0.0184906,
-0.02129843,
0.009738383,
-0.012012041,
-0.03846045,
0.026010111,
-0.021955876,
-0.029858895,
0.0067387964,
0.015134898,
0.0073688463,
0.009300087,
0.006043687,
0.01483357,
0.0046431953,
-0.009574022,
0.006937399,
0.003883026,
0.026736038,
-0.0038693293,
0.020531414,
0.01424461,
-0.008135864,
0.021887392,
-0.018216666,
0.028037228,
-0.012238038,
0.0142035205,
-0.004030266,
0.0076290844,
-0.004841798,
-0.11910686,
-0.016285425,
0.005954658,
0.02659907,
-0.008587857,
0.010950544,
-0.0050951876,
0.014765087,
0.0012549639,
0.02698258,
-0.019969847,
-0.028900122,
0.0015785494,
0.0042083235,
0.02710585,
-0.03673466,
-0.01588822,
-0.022435261,
-0.020736866,
0.04424047,
0.008327618,
0.0022787952,
-0.022120235,
-0.008642644,
0.0003180212,
-0.0006232017,
-0.0021486762,
0.008341315,
0.006975065,
-0.007882474,
-0.0077044168,
0.0029293904,
0.007670175,
0.00008335751,
-0.024448682,
-0.015901916,
-0.030954635,
-0.023051614,
0.02096971,
-0.017709885,
0.0014210369,
-0.010341039,
0.01542253,
0.007964655,
0.00079655106,
-0.018422116,
-0.05185586,
0.0040234174,
0.0073619983,
-0.035118442,
-0.028215285,
-0.024051476,
0.012388702,
0.011895619,
0.015093808,
-0.009738383,
-0.008491979,
0.009847957,
0.008457737,
0.015312956,
-0.00140734,
0.019572642,
-0.020476628,
0.032159947,
0.018737141,
-0.019846577,
-0.023558393,
-0.024434986,
-0.011162844,
-0.016942868,
-0.014491152,
0.018956289,
-0.012012041,
0.0029824653,
-0.011690168,
0.0024277472,
-0.01546362,
-0.024147354,
0.0037494828,
-0.032872178,
-0.0099712275,
-0.013244748,
0.016436089,
-0.007122305,
0.0076838713,
0.02399669,
0.0071291537,
-0.013546077,
-0.008259134,
-0.00602999,
0.028982304,
-0.0005816835,
0.0071907886,
-0.037419494,
-0.01928501,
0.007916716,
-0.03383095,
-0.015682768,
0.016422393,
0.01781946,
-0.038816564,
-0.023846025,
-0.06410075,
0.019969847,
0.0006921134,
-0.0136145605,
-0.0077044168,
0.007211334,
-0.0020219814,
0.010649215,
-0.010861515,
0.014614422,
-0.041583303,
0.0017471905,
-0.015066415,
0.0015366031,
-0.013484441,
0.0057937214,
0.039994482,
0.0069613685,
0.02950278,
0.010909454,
-0.010895757,
-0.022257203,
-0.014997931,
0.037803005,
-0.01668263,
0.0064443164,
0.011970951,
0.028270073,
0.0043555633,
-0.008560463,
0.007594843,
-0.039474007,
0.013128326,
-0.0037700278,
-0.016490877,
0.001903847,
0.015696464,
0.030899847,
0.026338832,
-0.0023421426,
-0.02572248,
-0.008786459,
0.023298156,
0.011868225,
-0.016737416,
0.016614147,
0.003146826,
0.0071154567,
0.010813577,
-0.0064956793,
0.009813715,
-0.014984234,
0.009957531,
-0.02824268,
-0.016874384,
0.0040987497,
-0.01718941,
0.02125734,
-0.038652204,
-0.019175436,
0.03492669,
0.0048007076,
-0.01025201,
0.012525669,
0.019956151,
-0.02714694,
0.0016418968,
0.011655927,
-0.013128326,
-0.014066553,
-0.02824268,
-0.019613734,
-0.021079283,
0.013463896,
-0.018819321,
-0.009450751,
0.021353219,
0.029913682,
0.0018781655,
0.028297467,
0.0009870214,
0.0026708643,
-0.014600726,
0.003917268,
0.0066086776,
0.013833708,
0.01353238,
0.014477455,
-0.024530863,
0.018244058,
0.006824401,
0.024804797,
0.016189547,
-0.0023438546,
-0.003513214,
0.013114629,
0.002682849,
0.0068380977,
0.023174886,
-0.012936572,
0.0055540283,
0.010073952,
0.0024962309,
-0.029639747,
-0.0007524647,
-0.0124229435,
-0.02462674,
-0.032324307,
-0.016244335,
0.00032829374,
0.02538006,
0.003365974,
0.02088753,
0.009478144,
-0.010649215,
-0.001332864,
-0.00004323034,
-0.017422253,
-0.022709196,
0.0087796105,
-0.002701682,
0.013669347,
0.019106952,
-0.016285425,
0.0529516,
-0.0036741507,
0.027119547,
-0.01487466,
0.035310198,
-0.011066967,
0.021051891,
-0.0038316632,
-0.028982304,
-0.022298293,
0.023572091,
-0.031146389,
-0.005879326,
0.013936434,
0.013251597,
0.08919317,
0.011964103,
-0.032132555,
0.0049753413,
-0.00458156,
0.0264758,
0.013861101,
0.033091325,
-0.0023729603,
-0.031502504,
0.014943144,
-0.00032144538,
0.0075742975,
-0.012744817,
0.011361446,
-0.019367192,
0.015477317,
0.008053684,
-0.005790297,
-0.000099943405,
0.014313094,
-0.0319408,
0.025530724,
0.0065984046,
-0.0105670355,
-0.013854253,
0.0015811175,
0.0039617824,
0.0072935144,
-0.033885736,
-0.008334466,
0.015573194,
-0.03147511,
-0.033228293,
0.015244473,
-0.030269796,
-0.011142299,
-0.0032581121,
0.0064443164,
-0.002239417,
-0.017435951,
0.016874384,
-0.02454456,
-0.030982027,
-0.023024222,
-0.047116786,
0.010525946,
-0.008348163,
-0.014272003
] |
The placental leucine aminopeptidase (P-LAP), adipocyte-derived leucine aminopeptidase (A-LAP) and leukocyte-derived aminopeptidase (L-RAP) belong to one distinct group of the M1 family of amimopeptidases, which we term the "Oxytocinase subfamily". They share HEXXH(X)18E Zn-binding and GAMEN motifs essential for the enzymatic activities. Intracellular localization is the characteristic feature of the subfamily members. While P-LAP is translocated from intracellular vesicles | [
-0.027551748,
0.0068268315,
0.003077336,
-0.0329426,
-0.014257927,
0.009736127,
0.004148378,
-0.005102301,
-0.026166692,
-0.0255149,
0.035984293,
-0.00051175774,
-0.013124082,
0.011277341,
-0.012343291,
0.010387919,
0.021033838,
0.005740513,
-0.0014588916,
0.012540187,
-0.018358778,
-0.0037851403,
-0.0035373238,
-0.01941794,
0.011379184,
-0.00016294775,
0.0043011415,
-0.035984293,
-0.001955373,
-0.017747724,
-0.005526644,
-0.008344282,
-0.004263799,
0.019825308,
-0.022771947,
-0.022826264,
-0.0044335364,
-0.025732163,
0.002284663,
-0.009070758,
0.023111422,
0.011759396,
-0.0017975173,
0.00418572,
0.0028057564,
-0.0124722915,
-0.01342282,
-0.009498496,
-0.015575089,
0.011250184,
0.00072138326,
-0.0032334942,
-0.004847695,
0.0016973723,
-0.0068505947,
0.0123704495,
0.00095477194,
0.019499414,
0.007855439,
-0.027972696,
-0.00091742974,
0.015534352,
-0.01609109,
0.021020258,
0.01276424,
0.029031856,
-0.0038530352,
0.03375734,
0.026519746,
0.018698253,
0.0273888,
0.010998973,
-0.0065891994,
-0.012451923,
0.014448033,
-0.025338374,
-0.038347036,
-0.015656563,
-0.010958236,
0.021970788,
0.012024186,
0.0010235155,
-0.017598355,
0.025161847,
0.021237522,
-0.02484953,
-0.00957318,
0.011582868,
-0.00931518,
-0.002895717,
0.014719613,
0.016647827,
0.019567307,
0.023736054,
-0.021291839,
0.011650763,
-0.009552811,
0.0020538205,
0.0011856146,
-0.01702804,
-0.0024662819,
0.013001872,
-0.0069863843,
-0.01315803,
-0.017204566,
-0.009057179,
-0.01662067,
-0.0053263544,
0.040003672,
0.025854375,
-0.011786553,
0.040981356,
0.01476035,
-0.036608927,
0.015670141,
-0.021291839,
0.035522606,
-0.0063583567,
-0.021414049,
-0.004355457,
0.027157957,
0.03321418,
0.020382047,
-0.012879661,
0.02165847,
0.012132817,
-0.004582905,
-0.009749707,
-0.015140561,
0.01049655,
0.01728604,
0.021373313,
0.01528993,
0.0029296647,
-0.017272461,
0.009179389,
0.0035848503,
-0.018711831,
-0.020626469,
-0.0115489215,
0.017978568,
0.03549545,
-0.01395919,
0.010381129,
-0.0031588098,
0.033567235,
0.023980476,
0.0107070245,
0.008751651,
0.024931004,
0.017326776,
-0.02843438,
-0.0037919297,
-0.023464475,
-0.003104494,
0.014773929,
0.012078501,
0.02446932,
-0.029955227,
-0.013348136,
-0.017299619,
0.00038296962,
-0.010163865,
0.022636157,
0.024713742,
0.021481944,
0.02180784,
0.011256973,
0.0032674416,
-0.007964071,
0.010842814,
-0.01845383,
-0.024564372,
0.00544517,
-0.009586759,
-0.0003653594,
0.015439299,
0.017978568,
-0.009159021,
-0.034001764,
0.00088008755,
0.017978568,
0.0077468073,
0.012730292,
-0.009233706,
0.00538067,
0.030471228,
-0.027334483,
0.013545031,
-0.017190987,
0.002420453,
0.009179389,
-0.020001836,
-0.03362155,
-0.6378861,
-0.02380395,
0.025949428,
0.008873862,
0.007020332,
0.030742807,
0.0033726788,
-0.011284132,
-0.0075702807,
0.027293747,
-0.023383,
0.024577951,
-0.007848649,
-0.008758442,
0.000870752,
-0.03644598,
-0.009016442,
-0.020151203,
0.01967594,
-0.02193005,
-0.030552702,
0.004464089,
0.0037919297,
0.011677922,
0.027008587,
0.025542058,
0.044593364,
-0.0077128597,
-0.0065314886,
0.014814666,
0.0014470099,
0.019825308,
-0.035957135,
0.0014639837,
0.053745598,
0.0036799032,
-0.013246293,
0.029575014,
0.016797196,
0.029439226,
-0.011331658,
-0.02087089,
-0.013144451,
0.0070814374,
0.0028651645,
0.003218218,
0.019662362,
0.021223944,
-0.023573106,
-0.015357825,
-0.004294352,
-0.0057133553,
-0.013674031,
0.015344245,
-0.0029279673,
0.025718585,
0.03921609,
-0.018956253,
0.013015451,
0.017381093,
0.01660709,
0.006059619,
-0.01474677,
-0.030009542,
-0.018711831,
0.011182289,
0.0025647297,
0.009063968,
-0.02205226,
0.010530498,
0.00024272424,
0.023165736,
0.012621661,
0.00072138326,
0.0048578796,
0.043153994,
-0.010713814,
0.025582796,
-0.00046805042,
0.017000882,
0.0024102686,
0.008412177,
-0.032155022,
0.005448565,
0.01581951,
0.024808794,
-0.004759432,
0.030063858,
0.009050389,
0.010150286,
0.027714696,
-0.0011864633,
-0.018385937,
-0.0390803,
-0.03549545,
0.005920435,
-0.029982384,
-0.002858375,
-0.0039005615,
-0.001968952,
-0.009294811,
-0.0029941648,
0.020816574,
-0.009783654,
0.04212199,
0.0005643763,
-0.024048371,
0.021088153,
0.029221961,
-0.011616816,
-0.012166765,
0.0013460162,
0.0043588523,
-0.019064886,
0.0046066684,
-0.025881533,
-0.0007922485,
0.0071289637,
-0.0024815584,
-0.04768937,
0.010041655,
-0.015914563,
-0.006470383,
-0.00091148895,
0.008283176,
0.03030828,
-0.00255794,
-0.023165736,
0.0037783508,
-0.006823437,
0.0098243905,
-0.00957997,
0.008256019,
-0.01435298,
0.0011728843,
0.02766038,
0.019051306,
0.014040664,
0.0053670914,
-0.030226806,
-0.014325823,
-0.014882561,
0.006018882,
-0.009539233,
-0.02206584,
-0.02631606,
-0.003141836,
0.0007014391,
0.012580924,
0.008194913,
-0.027307326,
0.0037138506,
-0.005699776,
0.016444143,
0.032888286,
-0.0012348384,
-0.029059013,
-0.013864137,
-0.015222034,
0.00037702883,
-0.013436399,
0.007957282,
-0.006249725,
-0.0029381514,
-0.003483008,
-0.023831107,
0.020911627,
0.007095016,
0.0029822832,
-0.03921609,
-0.004837511,
-0.01994752,
-0.025582796,
0.00432151,
-0.013497504,
0.016050352,
0.014230769,
0.0066401204,
-0.013395662,
0.006168251,
0.012811766,
-0.00864302,
0.0002422999,
0.010822446,
0.01249266,
0.024781635,
0.035305344,
0.011005762,
0.0075974385,
0.023287948,
-0.026030902,
0.0033641919,
-0.010836025,
0.027551748,
0.0082424395,
-0.0058253817,
0.0068030683,
0.0114878155,
0.004083878,
0.021739945,
0.025718585,
-0.021414049,
0.012852503,
-0.024157003,
0.004691537,
-0.024537215,
0.0046881423,
-0.033567235,
0.024713742,
0.0031978495,
-0.00916581,
0.0076789125,
-0.014583823,
-0.008133808,
-0.019336466,
0.010686656,
0.006952437,
0.009030021,
-0.0051124855,
-0.0038360613,
0.01819583,
0.009613917,
0.024931004,
-0.02233742,
-0.037423663,
0.005224512,
0.025093952,
0.03109586,
-0.013463557,
-0.037803877,
0.0080387555,
0.00671141,
0.017992146,
0.03068849,
-0.008738073,
-0.00040312592,
0.01581951,
-0.003910746,
0.015642984,
-0.02005615,
-0.018535305,
0.005027617,
0.01754404,
0.00018183101,
-0.0014071217,
-0.015412141,
0.006008698,
0.024673004,
0.00004137345,
0.0067453575,
-0.018698253,
0.036120083,
-0.016023194,
0.016946565,
-0.020952364,
-0.0025511505,
0.0057201446,
0.004240036,
0.036717556,
0.019648781,
0.0075023854,
0.0072647533,
-0.016199721,
0.007563491,
0.00025205978,
-0.007889386,
0.0025952822,
-0.023708897,
-0.008554757,
-0.019431518,
-0.004789985,
0.007957282,
0.016824353,
-0.038509984,
0.017055197,
0.008527598,
0.0024238476,
0.006100356,
0.010245339,
-0.0055877496,
-0.009736127,
-0.042067677,
0.032643866,
0.017218145,
-0.023668159,
0.0010837722,
-0.05276791,
-0.014190032,
0.005289012,
0.02484953,
0.011066867,
0.017734146,
-0.0007994624,
0.018779727,
-0.012309344,
-0.028461538,
0.022378156,
-0.025487743,
0.032535233,
-0.019811729,
-0.0072783325,
-0.0073054903,
-0.029330593,
-0.020626469,
0.07023048,
0.026750587,
0.010333602,
-0.026125954,
0.017340355,
-0.011372395,
0.007203648,
-0.0010956539,
0.011854448,
-0.0072783325,
-0.008208493,
0.0050038537,
0.0042705885,
0.010157076,
0.017761303,
0.0045863,
-0.021495523,
-0.032725338,
0.00007282788,
0.009736127,
-0.0059000663,
0.02271763,
0.006928674,
0.012730292,
0.011766185,
0.006562041,
-0.008609072,
-0.0072375955,
0.007325859,
0.0081813345,
-0.026886377,
0.005119275,
-0.0044199573,
-0.0047764056,
0.004464089,
0.011250184,
0.00080540316,
-0.0093016,
0.004840906,
0.0014716218,
0.021753523,
0.006263304,
0.015113403,
0.005635276,
0.0053093806,
0.0047017215,
0.024143424,
0.024496477,
0.0037376138,
-0.02723943,
0.0028227302,
-0.013918453,
-0.015738036,
0.010876762,
-0.017163828,
-0.014325823,
0.0015505496,
-0.0072375955,
0.033920288,
0.010754551,
0.016647827,
0.04252936,
-0.0005919586,
0.0021828208,
0.0026292298,
-0.014475191,
0.000078609555,
0.0114674475,
-0.0020572152,
-0.021101732,
0.022581842,
-0.0006390607,
0.020789417,
-0.021291839,
0.0107070245,
-0.020246256,
-0.0014665297,
-0.008398598,
0.0018365568,
-0.023899002,
0.0025613348,
-0.009994128,
-0.00034393006,
-0.009450969,
0.0045863,
-0.022255946,
-0.026479008,
-0.018969834,
-0.017910672,
-0.009498496,
0.005940803,
-0.022704052,
-0.014882561,
0.012465502,
-0.001841649,
0.0077468073,
0.008704125,
-0.024550794,
0.012811766,
0.031177334,
-0.013205556,
0.009498496,
0.002038544,
-0.03204639,
-0.0030756386,
0.0050411955,
-0.0038156928,
-0.020232677,
-0.019621624,
-0.024347108,
0.022771947,
-0.009260863,
0.020925205,
0.00797086,
-0.012635239,
0.010802077,
0.0080794925,
0.016226878,
-0.0022744788,
0.0036323767,
0.0114878155,
-0.050866853,
-0.013151241,
-0.012316134,
-0.015371404,
0.021115312,
0.016036773,
0.018548885,
-0.012112449,
0.0010888643,
0.010951446,
0.014325823,
-0.0043147206,
0.011684711,
0.017421829,
0.02592227,
-0.0065246993,
0.018385937,
0.004946143,
-0.021726366,
-0.02778259,
-0.0042468254,
0.012940766,
0.005064959,
-0.031014387,
0.029629331,
-0.01341603,
-0.020653626,
-0.012377239,
0.010082391,
0.002763322,
0.036228716,
0.009349126,
-0.014923298,
-0.030471228,
-0.002517203,
-0.029167647,
-0.0033947446,
0.0017033131,
-0.016281195,
-0.004508221,
-0.002352558,
-0.006365146,
-0.006436436,
0.012900029,
-0.028135644,
-0.006993174,
0.019988256,
-0.026003744,
-0.0037138506,
-0.018793305,
0.003588245,
-0.02418416,
-0.01807362,
-0.025487743,
-0.011073657,
-0.010442235,
-0.0132327145,
0.037939668,
0.021156048,
0.02949354,
-0.0056726183,
0.015982458,
0.017000882,
0.004199299,
-0.0035678765,
-0.0016506945,
-0.015072666,
-0.0028295196,
0.026098797,
0.017584777,
-0.013001872,
0.03204639,
-0.017829198,
0.008283176,
0.020286994,
-0.018956253,
-0.038890194,
0.025202584,
-0.028081328,
-0.010136708,
-0.012112449,
-0.008391809,
-0.009084336,
-0.043914415,
-0.022011524,
0.01103971,
-0.005394249,
0.004854485,
-0.018725412,
0.035685554,
-0.0073190695,
0.03413755,
0.035658397,
-0.0011372394,
0.00837823,
-0.014244349,
0.0052720383,
0.023776792,
0.0062259617,
-0.02259542,
0.017829198,
0.012689555,
-0.03440913,
-0.007217227,
0.020178363,
-0.007461649,
0.019703098,
0.009593548,
-0.016783617,
-0.006568831,
0.002890625,
-0.0055741705,
-0.052550647,
0.008269598,
0.0060154875,
-0.0116100265,
0.019825308,
-0.017788462,
-0.012886451,
0.025908692,
0.023518791,
0.017109513,
-0.033974603,
0.018250147,
0.013280241,
0.017706988,
-0.012601292,
-0.003496587,
-0.0031146782,
0.026424693,
0.028162802,
0.038482826,
0.014027085,
-0.011542132,
-0.016104668,
-0.0034931921,
-0.027320905,
-0.032671023,
0.021088153,
-0.029357752,
0.005692987,
-0.024048371,
-0.0003271685,
0.011596448,
0.0069999634,
-0.02593585,
0.011202658,
-0.01675646,
0.0016371156,
-0.02193005,
0.013653663,
0.016403407,
0.00009950845,
0.0000054899388,
-0.018168673,
-0.003374376,
-0.045136526,
-0.019431518,
-0.011895185,
0.017381093,
0.019214254,
-0.00051175774,
0.0076313857,
-0.00903681,
0.0058932765,
0.00034414223,
-0.01954015,
0.014719613,
0.04117146,
-0.0011346934,
0.0021794261,
0.020599311,
0.014027085,
0.021251101,
-0.0124722915,
-0.0015081153,
-0.010591603,
-0.01994752,
-0.009328758,
0.019689519,
0.0006708864,
-0.023383,
-0.00079861365,
-0.024387846,
-0.00319106,
-0.02657406,
-0.023763211,
0.021468366,
-0.043126836,
-0.009484917,
-0.0016311748,
0.0021811235,
-0.0035712714,
0.031829126,
-0.009688601,
-0.026017323,
0.01740825,
-0.02631606,
0.026465429,
-0.006371936,
0.00048884324,
-0.018996991,
0.0039582723,
-0.0051056957,
-0.00087414676,
0.022391735,
-0.031068703,
-0.01554793,
0.012404397,
-0.014502349,
0.006741963,
-0.0013511083,
-0.013932032,
0.00677591,
-0.01184087,
0.02046352,
0.005421407,
0.00023126698,
0.014977613,
-0.04730916,
-0.0053535122,
0.018019304,
-0.013341347,
-0.015738036,
0.0017245302,
-0.01928215,
0.020110467,
-0.015900984,
-0.0055470127,
-0.010041655,
-0.01328703,
0.00082025514,
0.0012764239,
-0.007685702,
-0.0066672782,
-0.0056318813,
0.0025189004,
0.0081202295,
-0.020382047,
-0.007936913,
0.013069767,
-0.0029517305,
0.015113403,
-0.0077943336,
-0.0023814132,
0.03017249,
-0.028543012,
-0.005438381,
-0.024673004,
-0.029086173,
0.035413977,
0.0005376427,
-0.024360687,
-0.021373313,
0.009362706,
-0.028923225,
-0.015126982,
-0.026737008,
0.009960181,
-0.012180343,
0.009688601,
-0.003031507,
-0.0037511927,
-0.00074896554,
0.010435445,
-0.023776792,
-0.024618687,
0.012682766,
-0.028950382,
0.026804904,
-0.0113045,
-0.01076134,
-0.033431444,
0.024754478,
0.01302224,
0.004681353,
0.021414049,
-0.023057105,
-0.002247321,
-0.011630395,
0.016634248,
0.018766148,
0.016389826,
0.015194877,
-0.011589658,
-0.0076313857,
-0.0010039958,
0.023573106,
-0.0018654122,
0.00052151765,
0.014027085,
0.0036187978,
0.005872908,
0.006371936,
-0.006487357,
0.022907736,
-0.0081813345,
0.020531416,
0.0069015156,
-0.014298664,
0.015751615,
0.006741963,
-0.018046463,
-0.018725412,
-0.010734183,
-0.026383955,
-0.0034541527,
0.017381093,
0.008385019,
-0.0030688492,
-0.009885496,
0.016484879,
-0.036255874,
-0.010557656,
0.022962052,
-0.0008465644,
-0.0057540922,
0.013062977,
0.00017525369,
0.0019774388,
-0.02379037,
0.0029619148,
-0.007984439,
-0.0070814374,
0.0019672546,
-0.009016442,
-0.0011915554,
-0.005034406,
0.0023101238,
-0.034897976,
0.0011966475,
-0.025365531,
-0.038808722,
-0.000024028426,
0.024510056,
0.18532589,
-0.015086245,
0.012384028,
0.0063176197,
-0.0006471232,
0.007549912,
0.0075159646,
-0.013735137,
-0.0123908175,
0.01994752,
0.025338374,
0.010679866,
-0.0025613348,
-0.005068354,
-0.016104668,
-0.000870752,
-0.024605108,
0.0005762579,
-0.015900984,
0.0074888067,
-0.004878248,
-0.0007328405,
0.035929978,
0.006395699,
0.02444216,
0.009321969,
-0.03307839,
0.006993174,
0.005024222,
0.010659498,
-0.009220126,
0.004929169,
-0.017367514,
0.008731283,
0.025066795,
0.0029330594,
-0.0036493505,
0.0019231228,
0.024292793,
0.016770039,
-0.006993174,
0.016824353,
-0.00096410746,
-0.006388909,
-0.03068849,
0.006259909,
0.007984439,
-0.01662067,
-0.0020589125,
0.022676894,
-0.03975925,
0.036201555,
0.016552774,
0.023641001,
-0.008738073,
-0.005119275,
-0.0066672782,
0.031530388,
-0.014515928,
0.034327656,
-0.00096750224,
0.0027293747,
-0.013463557,
0.016294774,
-0.016050352,
0.013701189,
0.008547967,
-0.023776792,
0.018711831,
-0.012703135,
0.014719613,
-0.011684711,
-0.003747798,
-0.012275397,
-0.015398562,
-0.01888836,
0.030226806,
0.024903847,
-0.0028363091,
0.013008662,
0.014868981,
-0.0023457685,
-0.04280094,
0.008704125,
-0.01249266,
-0.032209337,
0.01010276,
0.009308389,
-0.030525543,
-0.016851513,
-0.011535342,
-0.03870009,
-0.005356907,
-0.01103971,
0.0006297251,
-0.024659425,
0.0022558079,
-0.006833621,
-0.0031248624,
-0.031340282,
-0.0027565325,
0.07104521,
0.0115489215,
0.026411112,
-0.028135644,
-0.0056861974,
-0.0034134157,
0.026098797,
0.027062904,
0.00043198126,
0.010951446,
-0.019648781,
-0.013674031,
-0.036500294,
-0.02657406,
0.023844685,
0.02271763,
-0.013816611,
0.030199649,
-0.0024425187,
-0.016770039,
0.0029025066,
0.00571675,
0.013341347,
0.015629403,
0.0067691207,
-0.03375734,
-0.00651112,
0.011671132,
-0.0058016186,
0.0019095439,
0.0058695134,
0.0096614435,
0.008799178,
-0.0037308245,
-0.0032216127,
-0.016552774,
-0.00718328,
0.01888836,
0.01822299,
-0.018290885,
0.021047417,
0.01728604,
-0.009681812,
-0.00090979156,
-0.0028193353,
0.02498532,
0.01740825,
-0.00970897,
-0.006487357,
-0.008968915,
-0.033322815,
0.010876762,
-0.004864669,
0.025066795,
-0.016932987,
-0.012404397,
-0.014461612,
0.0042366413,
-0.011379184,
-0.009953391,
0.013117293,
0.01184087,
-0.02365458,
-0.0057133553,
-0.014081401,
-0.17250735,
-0.0024289398,
0.0036323767,
-0.00903681,
0.008968915,
0.03324134,
0.0032046388,
0.013449978,
0.007285122,
0.0050717485,
0.025691427,
-0.009260863,
-0.016444143,
-0.019879624,
-0.005557197,
0.0006500936,
0.0035644819,
0.015208456,
0.016172564,
0.0022625972,
0.0057506976,
-0.026750587,
0.011847659,
-0.015249193,
0.010218182,
0.021386892,
-0.0023848081,
0.00022872092,
-0.0059747505,
-0.005027617,
0.0063990937,
0.009627496,
0.043914415,
0.012438344,
0.024768056,
0.015846668,
0.006192014,
0.0023237027,
-0.0052448804,
0.018684674,
0.01554793,
0.013660452,
-0.010917499,
-0.012526608,
0.023627423,
0.034544922,
0.00019944125,
-0.013314188,
0.030661333,
-0.0011474236,
0.018032884,
-0.0140949795,
0.011942712,
0.028787434,
0.026302481,
0.019838888,
0.0009496798,
0.022771947,
-0.013932032,
-0.015113403,
-0.009559601,
-0.008717705,
0.042610835,
0.0040091933,
0.008500441,
-0.04413168,
-0.005584355,
0.011060078,
-0.035821345,
0.0090028625,
-0.028787434,
-0.021753523,
0.0162133,
-0.02324721,
0.021834997,
0.016987301,
-0.00046041224,
0.016783617,
0.020979522,
0.007964071,
-0.021862155,
0.017639093,
-0.034164708,
-0.013477136,
-0.01383019,
-0.007936913,
0.0010286076,
0.026302481,
0.00545196,
-0.014380138,
0.0140542425,
-0.028271433,
0.0025867955,
-0.02207942,
0.016783617,
0.015208456,
-0.030634176,
-0.010387919,
-0.0071968585,
-0.017856356,
0.019743836,
-0.0062700934,
-0.03777672,
0.012703135,
0.026764167,
0.013619715,
-0.011874816,
-0.0040091933,
0.033974603,
-0.03299692,
-0.004362247,
-0.025990164,
0.009688601,
0.026139533,
-0.008188124,
0.029602174,
0.005421407,
-0.020490678,
0.033132706,
-0.018304463,
0.053392544,
-0.00031571125,
0.02259542,
0.01634909,
-0.013354925,
-0.024835952,
-0.13111861,
-0.020232677,
0.016932987,
0.0089010205,
-0.021536259,
-0.0035067713,
0.0061954088,
0.030226806,
-0.0028651645,
0.032589547,
-0.012255028,
-0.0089824945,
0.00544517,
-0.01103292,
0.018100778,
-0.0059917243,
-0.015493615,
-0.023885423,
-0.054967705,
0.04453905,
0.006300646,
-0.0030841255,
0.02736164,
-0.00068191934,
0.022568263,
-0.02167205,
-0.019309307,
0.016131826,
0.015004771,
0.00850723,
0.019703098,
-0.0033590999,
0.026682694,
0.013185188,
-0.010849603,
-0.01863036,
-0.00026585095,
-0.0077128597,
0.030905755,
-0.0057099606,
0.0002847342,
-0.012906819,
-0.008344282,
-0.005913645,
-0.00029470626,
-0.016837934,
0.0069863843,
-0.011338447,
0.01820941,
-0.02592227,
-0.030552702,
-0.021237522,
-0.04318115,
-0.018793305,
0.027483853,
-0.022799104,
0.015194877,
0.03614724,
-0.020979522,
-0.041198622,
0.00029958622,
-0.0045964844,
-0.018141516,
-0.015099824,
0.019648781,
-0.012037764,
-0.015086245,
-0.022609,
0.008744862,
-0.0019587677,
-0.007617807,
0.010686656,
0.010727393,
-0.015004771,
-0.026383955,
-0.0036595347,
-0.0012390817,
-0.006938858,
-0.00085462694,
-0.009355916,
-0.013144451,
-0.021576997,
-0.0049529322,
0.0038632194,
-0.011990238,
0.0015216942,
0.008344282,
-0.0019248202,
-0.005397644,
-0.012974714,
-0.022500368,
0.036364503,
0.029656488,
-0.03299692,
-0.023057105,
-0.0010897131,
-0.02218805,
-0.013239504,
0.02406195,
0.015480036,
-0.03726072,
-0.015425719,
-0.053609807,
0.006371936,
-0.008425756,
0.0052720383,
0.017802041,
-0.0025290847,
0.007814702,
-0.010116339,
0.013660452,
0.006249725,
-0.031421755,
0.020314151,
-0.0030620596,
-0.010516919,
-0.003870009,
0.0074277013,
0.036228716,
0.027022168,
0.013653663,
0.010910709,
-0.001727925,
-0.00078163994,
-0.023383,
-0.0032895075,
-0.00916581,
-0.0025596374,
-0.012913609,
0.026560482,
-0.003666324,
0.015968878,
-0.029059013,
-0.040057987,
-0.03639166,
0.015004771,
-0.030389754,
-0.027429536,
-0.0069728056,
-0.016389826,
0.02660122,
0.0148554025,
-0.017476145,
-0.025895111,
-0.0028923224,
-0.013891295,
0.019078465,
-0.0045625367,
0.0062361457,
-0.006925279,
-0.008385019,
-0.019431518,
0.04744495,
0.0022116762,
0.00969539,
-0.033865973,
-0.015357825,
0.01050334,
0.008174545,
-0.012723503,
-0.0024764661,
0.0033251524,
0.03362155,
0.006714805,
0.024401424,
0.012350081,
0.0041110357,
-0.0019180307,
-0.0061139353,
-0.0066129626,
0.0066944365,
-0.010550866,
-0.011324868,
-0.0115692895,
0.0010056931,
0.018806886,
0.01196987,
-0.006857384,
-0.0162133,
0.009790444,
-0.019866046,
0.005903461,
-0.003350613,
-0.0133345565,
-0.0042196675,
0.022391735,
0.020925205,
-0.015208456,
-0.03310555,
0.021128891,
-0.017992146,
0.00916581,
0.0010235155,
0.011263763,
-0.0040363516,
0.008547967,
-0.022554683,
-0.0036459558,
-0.024265634,
-0.021821419,
0.017802041,
0.027320905,
-0.0040906672,
-0.0008338342,
0.0030111384,
-0.016145406,
-0.014176453,
0.019200675,
-0.040519673,
-0.03758661,
0.013674031,
-0.00017037375,
0.017489724,
-0.0021369918,
0.0069015156,
0.0027701117,
-0.004464089,
-0.0038734036,
-0.0015403654,
-0.0002953428,
-0.0048103533,
0.020178363,
0.01528993,
-0.0054655387,
0.018548885,
-0.0014308848,
0.009688601,
0.015303508,
0.020232677,
-0.018155094,
0.036228716,
-0.0056828023,
0.01662067,
-0.009063968,
-0.032725338,
-0.017584777,
-0.0020775837,
0.021943629,
-0.002320308,
0.031476073,
-0.0081405975,
0.0928259,
0.00031868165,
-0.02593585,
0.005234696,
-0.0069422526,
0.030824281,
0.0034745212,
0.006327804,
-0.001755083,
-0.0061954088,
-0.006290462,
-0.007957282,
0.027945537,
-0.03337713,
-0.019866046,
-0.014312243,
-0.0057506976,
0.0052686436,
-0.011256973,
-0.029194804,
0.010401498,
-0.0006895575,
-0.0098651275,
0.024863109,
-0.030661333,
0.02006973,
0.029928068,
-0.00056183024,
0.014909718,
-0.02870596,
0.0052550645,
-0.010883551,
-0.04185041,
-0.011161921,
0.027741853,
-0.027687537,
-0.009851549,
-0.0131716095,
0.023111422,
0.017068775,
-0.011250184,
-0.018956253,
-0.018589621,
-0.014407296,
0.025338374,
-0.0047662216,
-0.005567381,
0.0037545876,
-0.034762185
] |
The generation of induced pluripotent stem cells (iPSCs) provides a novel method to facilitate investigations into the mechanisms that control stem cell pluripotency and self-renewal. Myc has previously been shown to be critical for murine embryonic stem cell (mESC) maintenance, while also enhancing directed reprogramming of fibroblasts by effecting widespread changes in gene expression. Despite several studies identifying in vivo target genes, the precise mechanism by which Myc regulates pluripotency remains unknown. Here we report that codeletion of c- and N-MYC in iPSCs and ESCs results in their | [
-0.03699374,
-0.01104948,
0.0066881888,
-0.03880793,
-0.035784274,
0.00045601287,
-0.018864965,
0.009859738,
-0.01727426,
-0.012396977,
0.013106879,
0.0048707104,
0.0035988044,
0.00463079,
-0.02060028,
0.0058698305,
0.037072614,
0.011522748,
-0.012600745,
0.04398758,
-0.036336422,
0.027055122,
0.0014847122,
-0.026923658,
-0.011338699,
0.019837793,
-0.0036382433,
-0.028001657,
-0.003352311,
-0.019285647,
0.009859738,
0.0054327156,
-0.0017435304,
-0.0071976087,
-0.032366235,
-0.01294255,
0.010845711,
-0.032418817,
-0.0025487423,
-0.009642824,
0.019640598,
0.02326898,
-0.013284354,
0.005830392,
0.0019111459,
0.014710729,
-0.016616946,
-0.0037105482,
-0.014776461,
0.024978003,
0.017011335,
-0.0034640545,
0.006569872,
0.00578438,
-0.02391315,
-0.010286993,
0.0025947543,
0.02723917,
0.019614305,
-0.010760261,
0.010379017,
0.0048477044,
-0.018220795,
0.01392195,
0.009557373,
0.018365405,
-0.010779981,
-0.010109518,
0.01065509,
-0.009866311,
0.04950903,
0.0122392215,
-0.0016515062,
0.007585425,
-0.005836965,
0.0013483192,
-0.024189224,
0.0007456427,
-0.0056529166,
0.020297915,
0.011332125,
-0.029000776,
-0.0035264997,
0.034180425,
0.0029168392,
0.00855168,
0.0060670255,
0.010451322,
0.005360411,
0.0074342424,
0.014250608,
0.0506922,
0.01092459,
0.0077563273,
-0.02188862,
0.004029346,
-0.006727628,
0.03951783,
0.011286113,
-0.012186636,
-0.024583613,
0.020376792,
0.0046669426,
-0.02124445,
-0.036336422,
0.0016096022,
0.013987682,
-0.016117385,
0.035337303,
0.0016523277,
-0.015223435,
0.018878112,
-0.010464469,
-0.04401387,
0.032471403,
-0.011332125,
0.0060900315,
0.020258475,
-0.02834346,
0.009991202,
0.022677397,
0.017024482,
0.0092221415,
-0.022269862,
0.0133303655,
0.03281321,
-0.014158584,
0.00863713,
-0.007499974,
-0.0008610838,
0.031971842,
-0.010878578,
0.00250273,
0.03231365,
-0.018510016,
-0.013527561,
-0.0042856997,
-0.016117385,
-0.013619585,
-0.034601107,
-0.020587133,
0.027922777,
-0.010102944,
0.0037992857,
-0.007545986,
0.006947829,
0.00627408,
-0.013113451,
0.016275141,
0.00514021,
-0.0024928704,
-0.015578386,
0.028974483,
0.0038945966,
0.0016416464,
0.017984163,
0.016695824,
0.0059815743,
-0.023939444,
0.0008105526,
-0.0021707856,
-0.017826406,
0.010536773,
0.0059224158,
0.00965597,
0.03326018,
-0.0027295041,
0.008255888,
0.0033112287,
0.0012809443,
0.0037434138,
0.023637079,
-0.036757104,
0.023374151,
-0.027002536,
0.01492107,
-0.015801873,
0.014132291,
-0.021928057,
-0.008722582,
-0.010148957,
0.02380798,
0.015354899,
0.008814606,
-0.0099649085,
-0.0071844626,
0.020087574,
-0.011233528,
-0.0065140002,
-0.016932458,
-0.0032454971,
0.0055214535,
0.0052651,
0.004187102,
-0.62050617,
-0.04254148,
0.020915791,
-0.0087357275,
0.0075131203,
0.033864915,
0.01727426,
-0.005685782,
-0.0076905955,
0.025924537,
-0.008170436,
0.022322446,
0.017839553,
-0.019653745,
-0.0065140002,
-0.01941711,
-0.007848351,
-0.027396925,
0.0069215363,
-0.00088984135,
-0.017142799,
0.011226955,
-0.01781326,
0.031603746,
-0.021757156,
0.023150666,
0.042962164,
-0.012857098,
-0.0042232545,
0.044934113,
-0.014631852,
0.026910512,
-0.018996429,
-0.017142799,
0.041831583,
0.013212049,
-0.0051599294,
0.021139279,
0.0043119923,
0.040701,
-0.01866777,
0.0063562444,
0.024412712,
0.0105696395,
0.00031592243,
0.025043735,
-0.0073882304,
0.01585446,
-0.00463079,
-0.0061886287,
0.014737022,
0.002292389,
-0.018352259,
-0.008932923,
0.018536307,
0.0014050127,
0.020836914,
-0.009386471,
0.044329382,
-0.0027541535,
0.009596812,
0.027449511,
-0.032366235,
-0.0042692665,
-0.009353605,
0.024570467,
-0.00801268,
-0.0071910354,
0.012699342,
-0.030604627,
-0.0045354795,
0.02530666,
-0.023019202,
0.012410124,
0.00552474,
0.024912272,
-0.013152891,
-0.0076314374,
0.0024320688,
-0.009537653,
0.0001704913,
-0.014237462,
-0.008873764,
0.0040194867,
0.020337353,
-0.002313752,
-0.009070959,
0.01745831,
-0.021257596,
0.017379431,
0.0152102895,
-0.016643237,
0.012646757,
-0.052138295,
-0.035205837,
0.0041115107,
-0.005820532,
0.0017386004,
0.015052534,
-0.03123565,
-0.016275141,
0.0050810515,
0.016327726,
-0.0018996429,
0.01152932,
-0.002880687,
-0.016893018,
0.021481082,
0.05048186,
-0.036783397,
0.017024482,
-0.008886911,
0.0077234614,
-0.007933803,
-0.008998654,
-0.02370281,
0.005327545,
0.0020228897,
-0.009537653,
-0.016682677,
0.0033539543,
-0.01417173,
-0.005859971,
0.006336525,
0.012357539,
0.007966668,
-0.004417163,
-0.0014986802,
-0.0029694245,
0.0020853346,
0.002803452,
-0.022335593,
0.01991667,
-0.046038404,
0.014684437,
-0.0037401272,
0.013159464,
0.0052223746,
0.009603385,
-0.023558201,
-0.03515325,
-0.010109518,
0.008144144,
-0.0047326745,
0.0011650923,
-0.014408364,
-0.01028042,
-0.0074671083,
0.024754515,
-0.011739661,
0.0013524274,
-0.0039044563,
0.0072633405,
0.008965788,
0.021507375,
-0.005882977,
-0.0057219346,
-0.021796593,
-0.008499094,
-0.021362767,
-0.019338233,
0.043251384,
-0.010602505,
0.0036842555,
0.007296206,
-0.0031238936,
-0.00790751,
0.002972711,
-0.011660784,
-0.022309301,
-0.008242741,
0.012127478,
-0.0023055354,
-0.0037105482,
0.0009185989,
-0.008209875,
-0.017905284,
-0.004164096,
-0.013060866,
-0.006796646,
-0.0069806944,
-0.02384742,
0.020429377,
-0.0078023393,
0.01845743,
0.02234874,
0.015118265,
-0.0068952437,
0.0021428498,
0.033181306,
-0.011969722,
0.0076840227,
-0.01367217,
0.012252368,
0.013619585,
-0.013764194,
0.012009161,
0.008978935,
0.006372677,
0.03273433,
0.0027360774,
-0.019561721,
0.017589772,
-0.02684478,
0.01916733,
-0.041857876,
0.0039504683,
-0.020363646,
0.0114044305,
0.015525801,
-0.0054360023,
0.010747114,
-0.0020672583,
-0.0107076755,
0.014802753,
-0.013777341,
-0.013093732,
-0.023860566,
-0.022335593,
0.0123312455,
-0.0046702293,
0.0008643704,
0.009708555,
0.008328192,
0.012410124,
0.019588012,
0.0064088297,
0.01916733,
-0.0057679466,
-0.010352725,
-0.00035659387,
0.017182237,
-0.0064877076,
-0.00326193,
0.015118265,
0.02474137,
0.0027755164,
-0.019495988,
0.04648538,
-0.0049660215,
0.004920009,
0.026424099,
0.008321619,
0.0035725117,
-0.016156824,
-0.012265515,
0.029184824,
-0.000019591094,
-0.016985042,
0.013908803,
-0.029921018,
0.01292283,
-0.010641944,
-0.008400497,
0.0041673826,
-0.018299675,
0.0053768437,
0.001293269,
0.029474044,
0.019049013,
-0.00288726,
-0.034679987,
0.010102944,
-0.0141191445,
-0.00225788,
0.009471921,
0.009912323,
-0.02070545,
-0.020968376,
-0.017142799,
-0.03205072,
0.013474976,
0.027870193,
-0.015368045,
0.009623105,
-0.008400497,
0.024281248,
0.016196262,
0.008479374,
-0.0014937503,
-0.009682262,
-0.03510067,
0.029973604,
0.019693183,
-0.0028281016,
0.010858858,
-0.045091867,
-0.021901764,
-0.0042462605,
0.004075358,
-0.00044450985,
0.00089723617,
-0.012863671,
0.0054360023,
-0.008413644,
-0.020363646,
0.009452202,
-0.016748408,
0.016840432,
0.006392397,
0.005735081,
-0.0020081,
-0.01527602,
-0.005445862,
0.019666892,
0.015052534,
-0.0071515967,
-0.026174318,
-0.0149079235,
-0.016879871,
-0.010116091,
-0.0032471404,
0.008623985,
-0.009544226,
-0.009774287,
0.0018355546,
0.021770302,
-0.0036448166,
0.021467937,
0.014211169,
-0.006116324,
-0.030262822,
0.0006051414,
0.00053899904,
0.036099788,
0.026200611,
-0.014184876,
0.0053538377,
0.00004421476,
0.0051927953,
-0.00070045225,
-0.024307542,
0.026871072,
-0.031998135,
-0.0014592413,
0.014710729,
0.009984628,
-0.02205952,
0.0061524766,
0.030578334,
-0.00953108,
-0.018943843,
-0.019903524,
-0.020074427,
0.00072838814,
0.0034509082,
0.01567041,
0.04112168,
0.022861445,
0.006093318,
0.0000033828658,
0.009169556,
-0.013501268,
-0.008584545,
-0.011562186,
0.0031074607,
0.007046426,
0.005606904,
-0.00313704,
-0.016735261,
0.020100718,
0.030420579,
-0.014723876,
0.022743128,
0.030315408,
0.012574453,
0.005472155,
-0.008229595,
-0.0057449406,
-0.0019785208,
-0.017655505,
0.008393924,
-0.013645877,
-0.033444233,
0.010471042,
-0.025490709,
-0.027212877,
-0.00863713,
0.014697582,
0.0032487838,
0.0055576055,
-0.01063537,
0.0076051448,
0.00010517054,
-0.007572279,
-0.022388179,
-0.006405543,
0.0047852597,
-0.008814606,
-0.013751048,
0.011851405,
-0.009255008,
-0.033391647,
-0.010273847,
0.020429377,
-0.022033228,
-0.033917498,
0.018851819,
0.00082041236,
0.02934258,
0.02384742,
-0.01242327,
-0.00788779,
0.030604627,
0.010806273,
-0.023794834,
0.012857098,
-0.030367993,
0.010359298,
0.0018174783,
0.0054097096,
-0.0034016096,
-0.016222555,
0.0024041329,
0.026805341,
-0.009616531,
0.000626915,
-0.0030450157,
-0.017734382,
0.011292687,
0.009708555,
0.017760675,
-0.0017238109,
-0.015985921,
-0.00903152,
-0.030394286,
-0.041673828,
-0.023610786,
-0.01028042,
-0.010556493,
0.0007197609,
0.014250608,
-0.03113048,
0.007960095,
0.024254955,
-0.0026654159,
0.02060028,
0.0083413385,
0.010260701,
0.031104187,
-0.017747529,
0.012456136,
-0.001670404,
-0.015722996,
-0.003562652,
-0.02484654,
0.028369753,
0.018759795,
-0.041831583,
0.0040162,
0.0063463845,
-0.008525386,
-0.037913978,
0.002671989,
-0.014894778,
0.04619616,
-0.018772941,
-0.01492107,
-0.0075196936,
-0.008669997,
0.015552093,
0.026187465,
-0.00084054266,
-0.028895605,
-0.009563946,
0.012022307,
0.00077686517,
-0.008065266,
0.039596707,
-0.040858753,
0.0024895838,
0.03473257,
0.03294467,
0.0059125563,
0.0069018165,
0.017931577,
-0.006260934,
-0.02330842,
-0.021415351,
-0.026397806,
0.013527561,
-0.028790435,
0.061892863,
0.038150612,
0.038439833,
0.019890377,
0.0067637805,
-0.004384297,
0.011417577,
0.00765773,
-0.015499508,
0.038886808,
-0.024649344,
0.028211998,
-0.0040654987,
0.0058895503,
0.041542362,
-0.028474923,
0.0077103153,
0.028974483,
-0.011667357,
-0.0049594482,
0.0137247555,
-0.01924621,
-0.037835103,
0.01991667,
-0.0071121575,
0.004873997,
-0.030788675,
-0.004860851,
-0.01265333,
-0.0018256948,
0.0035067801,
0.016656384,
0.02844863,
-0.022427617,
0.028238289,
-0.007966668,
0.011246675,
-0.009879458,
0.0006947007,
-0.008952642,
-0.01924621,
0.005219088,
-0.009504788,
0.013751048,
-0.0026391232,
-0.025372393,
0.018141918,
0.031261943,
-0.033917498,
-0.00840707,
0.00018599984,
-0.035731692,
-0.0073948037,
-0.010825993,
-0.016735261,
-0.019141039,
0.0029759975,
0.015131411,
-0.026976243,
0.017655505,
-0.006803219,
0.00006413965,
0.0149079235,
0.005294679,
0.0099649085,
-0.012574453,
0.019338233,
0.04133202,
0.00878174,
-0.02191491,
-0.019022722,
-0.018102478,
-0.003053232,
0.040753584,
0.0198115,
0.011976295,
-0.025332954,
0.01417173,
-0.00060924963,
-0.01681414,
-0.025622172,
0.0010648518,
-0.0034410486,
-0.003851871,
-0.017326847,
-0.00026107766,
-0.029815847,
-0.0006815544,
-0.005633197,
0.019995548,
-0.008814606,
-0.011989442,
-0.011437296,
0.023860566,
0.0072304746,
0.00029948953,
0.01127954,
-0.01556524,
-0.012495575,
-0.0099649085,
-0.011719942,
0.0107536875,
-0.012390404,
0.02773873,
-0.01706392,
0.00058213534,
0.0047326745,
-0.017760675,
0.0076445835,
-0.014342632,
0.0026243336,
0.040832464,
0.0022381605,
-0.0072436207,
-0.01290311,
0.0008413643,
0.009616531,
-0.035284717,
-0.010162103,
-0.0099188965,
-0.035731692,
0.0016786203,
0.029684385,
0.0010204829,
-0.0021412065,
0.0058632577,
-0.024386419,
-0.018102478,
-0.023150666,
-0.019982403,
0.012206356,
-0.019377671,
0.011601625,
-0.0046242173,
0.04191046,
0.0020771183,
-0.0121471975,
0.0074802544,
0.001429662,
0.032760624,
-0.013895658,
0.016104238,
-0.0019505848,
-0.022217276,
-0.0063430984,
0.0057876664,
-0.010576213,
-0.0296318,
-0.012449563,
-0.016971895,
-0.033181306,
-0.0006786786,
-0.0092221415,
0.041384608,
0.00093010196,
-0.0068952437,
0.0022891024,
0.008669997,
0.010490761,
-0.020626573,
-0.010872005,
-0.004118084,
-0.014842193,
-0.004492754,
0.013882511,
0.0042791264,
-0.013645877,
-0.012166916,
-0.016143678,
0.013580146,
-0.02984214,
-0.007703742,
-0.010056932,
-0.0114504425,
-0.0067835,
0.00091695564,
-0.02195435,
-0.01317261,
-0.016840432,
-0.008913203,
0.014579266,
-0.0059322757,
-0.038098026,
-0.009070959,
0.0105302,
0.005593758,
-0.008939496,
0.009347032,
-0.023821127,
-0.040490657,
-0.03441706,
0.018654624,
-0.021967497,
0.051034003,
0.021757156,
0.019535428,
-0.023295274,
-0.0044434555,
-0.061840277,
-0.03373345,
0.014434656,
0.021402204,
0.013829926,
-0.00992547,
-0.022624813,
-0.0091301175,
-0.00476554,
0.016091092,
0.0057548005,
-0.028396046,
0.0048805703,
0.0008849115,
0.010208116,
0.017287407,
-0.023255836,
-0.008900057,
0.02852751,
0.010254128,
-0.0062642205,
0.022624813,
-0.004844418,
0.042778116,
-0.011364992,
0.017576626,
0.010714249,
0.018983282,
0.034259304,
-0.016945602,
-0.011266394,
0.013698462,
-0.0047228145,
-0.01054992,
0.006297086,
0.00225295,
-0.012857098,
0.007381657,
0.0031896252,
-0.016340872,
-0.0067013353,
-0.014290047,
0.02923741,
0.008492521,
0.01852316,
0.0317615,
0.01616997,
-0.0024682211,
-0.03491662,
0.026502976,
0.005107344,
-0.003585658,
0.0044467417,
0.0054820143,
-0.016761554,
-0.005406423,
-0.0160648,
-0.026752755,
-0.016787848,
-0.0030926713,
-0.0010237695,
-0.014487241,
0.016616946,
-0.025438124,
-0.024044614,
-0.007591998,
-0.0052683866,
-0.0022513068,
-0.028474923,
-0.005156643,
-0.016998189,
-0.010398737,
-0.0012316456,
0.003125537,
-0.0030252964,
0.0098728845,
0.0009818656,
0.012212928,
0.0018717069,
0.01831282,
0.199193,
-0.0041673826,
0.016577506,
0.009846591,
0.013593292,
-0.0121471975,
0.016183117,
-0.01063537,
-0.0041115107,
0.0072107553,
-0.0065435795,
0.013961389,
-0.011338699,
-0.0072567672,
0.020363646,
-0.0246362,
-0.021625692,
0.002103411,
-0.022401325,
-0.01860204,
0.018891258,
-0.01866777,
0.016327726,
0.008045546,
0.020113865,
0.0009621461,
-0.0321296,
0.027502095,
0.0095508,
0.012482428,
-0.02852751,
0.013764194,
-0.012837379,
0.003920889,
-0.001432127,
0.012245795,
0.0015249728,
-0.019338233,
0.006448269,
-0.026292635,
-0.010339579,
-0.004998887,
0.0027278608,
0.0036382433,
0.015999068,
0.022309301,
-0.015039387,
-0.006320092,
0.009997774,
0.002093551,
-0.052006833,
0.011535893,
0.0075525595,
0.0148159,
0.0009982985,
-0.011397857,
0.010641944,
0.003874877,
0.0030877413,
0.012456136,
-0.0006725163,
0.0020458957,
-0.026226902,
0.018996429,
-0.015801873,
0.010076652,
-0.01492107,
0.0107536875,
0.020797474,
-0.023176957,
-0.017366285,
-0.010194969,
-0.011194089,
0.0009489998,
0.011134931,
-0.03454852,
0.052006833,
0.0042561204,
0.023466177,
0.0210604,
0.014789607,
0.013777341,
-0.033470523,
-0.007381657,
0.002745937,
-0.030841261,
0.025609026,
0.0061919154,
-0.041226853,
-0.022914032,
0.0083873505,
0.00400634,
-0.0052683866,
-0.0106156515,
0.005248667,
0.009103824,
0.00007025064,
0.0055050203,
-0.006796646,
-0.011877698,
-0.037756223,
0.064206615,
0.024517883,
0.018746648,
-0.0058862637,
0.018680917,
0.003329305,
0.011154651,
-0.029184824,
-0.001031986,
0.023006056,
-0.023255836,
-0.0020179597,
-0.00801268,
-0.009945189,
0.013711609,
-0.0021362766,
-0.030367993,
0.043251384,
-0.0019242922,
-0.021007815,
-0.018720357,
-0.0027475804,
0.022177838,
-0.00013680386,
0.00044245576,
-0.014000828,
-0.004206822,
-0.03801915,
-0.030762382,
-0.013790487,
0.001506075,
0.00903152,
0.0059092697,
0.018194504,
0.00022369281,
0.014579266,
-0.009886031,
-0.024110345,
0.012061746,
-0.019219916,
0.002364694,
0.01367217,
0.010254128,
0.009833446,
0.008827752,
0.014829046,
0.032602865,
0.012751928,
-0.0198115,
-0.007933803,
-0.022151545,
-0.0010960742,
-0.004229828,
0.025319807,
-0.0064022564,
-0.006960975,
-0.035863154,
-0.011351845,
0.020784328,
-0.029658092,
0.030867552,
-0.0048904303,
0.013540707,
0.007092438,
-0.0121932095,
-0.16343501,
-0.013106879,
0.023794834,
-0.020639718,
0.024688784,
0.023479322,
-0.021586252,
-0.020771181,
-0.0030647353,
0.0007538591,
0.038439833,
0.013987682,
-0.04858879,
-0.027212877,
0.01724797,
0.03544247,
-0.005859971,
0.036783397,
0.013540707,
0.012304953,
0.027055122,
-0.010687956,
0.0149079235,
-0.0060900315,
-0.0019637311,
-0.019035868,
0.0006207527,
-0.02455732,
-0.011838259,
-0.023032349,
-0.0031929119,
0.0066914754,
0.040464364,
-0.0036283836,
0.022388179,
0.012613892,
-0.0063430984,
-0.0034837741,
0.003960328,
0.018746648,
0.028027948,
0.010162103,
-0.003664536,
0.0068097925,
0.0059552817,
0.036362715,
-0.0047622533,
0.00026847245,
0.021375911,
0.010582785,
0.0180236,
0.014395217,
-0.004180529,
0.003937322,
0.009833446,
0.004528906,
0.02934258,
-0.003943895,
-0.01156876,
0.0014387001,
-0.007000414,
-0.00086765696,
0.034864035,
-0.014066559,
0.004985741,
-0.0360472,
0.0022956757,
0.019640598,
-0.035942033,
0.004781973,
-0.008223021,
-0.0013910447,
0.0064252624,
-0.008834326,
0.035679106,
-0.007000414,
0.0017977589,
0.006803219,
-0.006451555,
0.012442989,
-0.02670017,
0.018746648,
-0.03265545,
-0.035652813,
-0.009563946,
-0.012350965,
0.012212928,
0.01129926,
-0.01163449,
0.003437762,
0.021586252,
-0.02655556,
-0.005219088,
0.0012439702,
0.020679157,
0.01127954,
-0.010648517,
-0.01745831,
-0.01431634,
0.0058238185,
0.030657211,
-0.015762435,
-0.0075985715,
-0.000054947497,
0.04322509,
-0.012804513,
-0.013829926,
0.007217328,
0.04911464,
-0.031472284,
0.005205942,
0.007493401,
0.00790751,
0.02520149,
0.004272553,
0.030999016,
0.009669117,
0.016735261,
-0.0034279022,
-0.0074210963,
0.07624864,
0.000045575613,
0.0024024895,
0.032681745,
0.003657963,
-0.0014140508,
-0.13882512,
-0.033365354,
0.006372677,
0.02453103,
-0.016551213,
0.01652492,
-0.01017525,
0.02326898,
-0.00043875835,
0.016288288,
-0.009649397,
-0.013198903,
0.00930102,
-0.013001708,
0.0057876664,
-0.013461829,
0.007000414,
-0.0063102324,
-0.035258424,
0.026240049,
0.003030226,
0.01367217,
-0.01795787,
-0.020823767,
0.020902645,
0.041358314,
-0.040963925,
0.03152487,
0.014290047,
0.01756348,
0.008347912,
-0.018943843,
0.021152426,
-0.003250427,
-0.023926297,
0.0022036515,
0.01727426,
-0.031656332,
0.04133202,
-0.021941204,
-0.0062872265,
-0.0046899486,
0.015039387,
-0.0011733088,
0.009879458,
-0.008650277,
-0.0017435304,
-0.0061984886,
-0.00052708515,
-0.021402204,
-0.049088348,
-0.02295347,
-0.0069741216,
0.0026752756,
0.010333005,
-0.02334786,
0.011443869,
0.0035100668,
-0.0180236,
-0.009997774,
0.014842193,
-0.016380312,
-0.029079653,
-0.0056890687,
0.008854045,
-0.012712489,
-0.03152487,
-0.041673828,
0.031288236,
-0.022230422,
-0.021862326,
0.0035988044,
-0.011595052,
0.0077694734,
-0.03333906,
0.0041673826,
-0.0043448578,
-0.026174318,
-0.0026522696,
-0.025148906,
-0.00892635,
-0.023466177,
0.012212928,
-0.03205072,
0.037493296,
-0.00054351805,
0.014539827,
-0.0043810103,
-0.0020163164,
0.008196729,
-0.003937322,
0.023400445,
-0.007999534,
-0.018155064,
-0.0013935097,
-0.0058106724,
-0.005051472,
0.0064975675,
0.009425909,
0.02455732,
0.013461829,
-0.0153023135,
-0.05305854,
0.019758916,
-0.013060866,
0.0079009365,
0.0013778984,
-0.022637958,
0.015341752,
-0.017550334,
0.00024649344,
0.013054294,
-0.02199379,
0.011200663,
-0.005945422,
0.004844418,
-0.023545055,
-0.014290047,
0.03991222,
-0.008518814,
0.007348791,
0.029184824,
-0.006550153,
-0.01870721,
0.0092221415,
-0.0025224497,
0.00023848242,
0.010668237,
-0.019772062,
0.036757104,
-0.012692769,
-0.01592019,
-0.000990082,
-0.037467003,
-0.02474137,
0.010109518,
-0.013895658,
-0.01190399,
0.011838259,
0.043041043,
0.019864086,
0.028869312,
0.011792246,
-0.031183064,
0.028974483,
0.010799699,
0.0018125485,
0.014855338,
-0.03914973,
0.0039471816,
0.0014428083,
-0.006569872,
0.029815847,
0.0043021324,
0.007618291,
-0.011917137,
-0.00032496054,
-0.025582734,
0.013698462,
-0.0060045803,
-0.008104704,
-0.01781326,
-0.0079469485,
0.008900057,
0.020219035,
0.0006211635,
-0.022716837,
-0.015499508,
-0.044355676,
-0.003329305,
0.0061886287,
-0.0296318,
-0.025148906,
0.016012214,
0.025832513,
0.0030663786,
0.014092852,
-0.002234874,
-0.013218622,
0.017760675,
-0.016551213,
0.029526629,
0.0076511567,
0.0056792093,
-0.014697582,
0.0070332796,
0.030946432,
-0.0014444516,
-0.009439056,
0.013428963,
0.006326665,
-0.011660784,
0.0071976087,
0.014027121,
0.0079009365,
0.007493401,
0.01227866,
0.021599399,
-0.008558253,
0.011601625,
-0.011338699,
0.030052481,
0.0012940906,
0.006126184,
0.017734382,
-0.03381233,
-0.01588075,
0.037782516,
-0.022401325,
-0.038439833,
-0.020573987,
0.006063739,
0.00080521195,
0.009511361,
-0.014618705,
-0.007539413,
-0.008847471,
0.007499974,
-0.005915843,
-0.018155064,
-0.0083413385,
0.041463487,
0.024202371,
0.003943895,
-0.0015668767,
-0.0018371978,
0.0076314374,
0.0047228145,
0.019680036,
-0.009471921,
0.03123565,
-0.0065337196,
0.043566898,
0.022966616,
-0.023663372,
-0.017878992,
-0.02045567,
-0.031577453,
0.009721702,
0.0132975,
-0.010227835,
0.07893049,
0.0009038093,
-0.020389939,
-0.010885151,
-0.01467129,
0.017865846,
0.020863205,
0.009208995,
-0.030762382,
-0.018904405,
0.01745831,
-0.016156824,
0.017944723,
-0.04133202,
-0.003835438,
0.015131411,
-0.020547694,
0.026003417,
-0.018930698,
-0.009767714,
0.0012472569,
-0.01945655,
0.015118265,
-0.0024928704,
-0.03751959,
-0.0028839733,
0.02434698,
-0.017997308,
-0.0066323173,
-0.000090997164,
0.0005422856,
0.00501532,
-0.034364473,
-0.00060144404,
0.011825113,
0.012258941,
0.011226955,
-0.017339993,
0.031209357,
0.011226955,
-0.015617825,
-0.008413644,
-0.0010599218,
-0.023124373,
0.0026571995,
-0.013402671,
-0.005294679,
-0.003023653,
-0.0072304746
] |
Multiple sclerosis (MS) shows a multifold increase in prevalence with an increase in latitudes, both north and south of the equator. One of the potential factors related to the difference of the prevalence is vitamin D, because the strength of ambient ultraviolet light, which is essential for vitamin D production, decreases with increasing latitude. It is known that vitamin D has immunomodulatory functions and suppresses an animal model of MS. It is also considered that vitamin D-related genes are critical susceptible genes for MS. An approach from environmental and genetic aspects is needed to investigate the association between vitamin D and MS. | [
-0.0058303946,
-0.006017846,
0.011072578,
-0.04054128,
-0.058588352,
0.03356032,
-0.022300288,
-0.0037458022,
-0.023593059,
-0.023334505,
0.0054716505,
0.0025839247,
-0.022390783,
0.022313217,
-0.024317011,
-0.0070455987,
0.048840865,
-0.006690087,
0.03079379,
0.0062699364,
-0.01970182,
-0.0027632967,
0.021240218,
-0.010652428,
0.000959074,
0.0063830535,
0.00092190685,
-0.038498703,
-0.0031042648,
0.004453594,
0.015720088,
-0.025932973,
-0.009126958,
-0.012901848,
0.0027939999,
0.007426966,
0.009172206,
-0.021925386,
-0.014401462,
-0.027484298,
0.0015892995,
0.013832643,
-0.019856952,
-0.007717839,
0.0106395,
0.026863769,
0.010419729,
-0.030431814,
-0.011906415,
0.033818875,
0.034697957,
0.029190755,
-0.016689666,
-0.0031252725,
-0.01486686,
-0.00830605,
0.009947868,
0.0024934309,
-0.000022547732,
-0.024653131,
-0.011887023,
0.014349751,
-0.01862882,
0.020283567,
-0.025351226,
0.0046539735,
-0.014970281,
0.010587789,
0.010852807,
0.017594606,
0.026475938,
0.03630099,
-0.0066028247,
0.007207195,
0.0050708917,
0.011227711,
-0.012701469,
0.011434554,
0.009030001,
-0.0049222233,
0.029501019,
-0.007892363,
-0.007504532,
0.0049836296,
0.012720861,
-0.0046022628,
-0.006079253,
0.018215135,
-0.0029749877,
-0.024407504,
-0.022158084,
0.0053391415,
0.023774046,
-0.0035939016,
-0.00584009,
-0.017982436,
0.03162116,
0.04351465,
-0.020012086,
0.010225814,
-0.016560389,
-0.0036553082,
-0.022946674,
-0.014970281,
-0.04116181,
0.01142809,
-0.008189701,
0.019288134,
0.016534533,
-0.033767164,
-0.018796882,
0.029087333,
0.011499193,
-0.03935193,
-0.0012758027,
0.0087908385,
0.010982084,
-0.0033450434,
0.003403218,
0.022481278,
0.031362608,
0.020050868,
0.011893488,
-0.0091657415,
0.025920046,
0.003012155,
-0.013819715,
-0.007026207,
-0.017465327,
-0.003836296,
0.0030250826,
0.010458512,
-0.0049383827,
0.010477904,
-0.029811285,
0.022300288,
-0.020257711,
-0.010348626,
-0.00018058385,
-0.013037589,
0.003099417,
0.0003357163,
-0.021990024,
0.0020393452,
0.0124946255,
0.01981817,
0.006311951,
0.009030001,
0.0006383054,
-0.026889624,
-0.0002737037,
-0.04971995,
0.022377856,
0.0041659526,
0.010180566,
-0.004188576,
-0.005633247,
0.030250827,
-0.024317011,
-0.042144313,
0.016586244,
-0.00906232,
-0.020981664,
-0.0062990235,
-0.0051387623,
0.032138273,
0.0004932727,
-0.018447833,
-0.007465749,
-0.004359868,
-0.010697675,
0.025971757,
-0.029966418,
0.02376112,
0.019197641,
0.022662265,
-0.024174806,
0.020348206,
-0.0106136445,
-0.0072136587,
-0.013134547,
0.018758098,
0.026152745,
-0.0021686223,
-0.023786975,
0.017245557,
0.028751213,
-0.0043986514,
0.028647792,
-0.00033309037,
0.0024207125,
-0.00934673,
-0.01908129,
-0.02792384,
-0.64824677,
-0.017348979,
0.007110237,
0.018926159,
0.0056170872,
0.023631843,
0.016069137,
0.013024662,
-0.015720088,
0.022830324,
-0.021705614,
0.012152041,
-0.018098785,
-0.009010609,
0.01896494,
-0.033974007,
-0.0033418115,
-0.028673647,
0.01740069,
-0.011305277,
-0.009605284,
0.0057399003,
-0.0008508045,
0.015513244,
0.014181691,
0.02758772,
0.008545212,
-0.025920046,
0.0036359166,
0.044031758,
-0.0129083125,
0.0120809395,
0.019572543,
0.00698096,
0.04886672,
-0.015267618,
-0.005096747,
0.017672172,
0.012740252,
0.0370508,
-0.024200661,
-0.01055547,
0.0016547461,
-0.011550903,
0.006328111,
0.024911685,
0.016521605,
-0.003959109,
0.02769114,
0.0064315326,
0.027380876,
0.019249352,
-0.01615963,
-0.038188435,
0.028854635,
-0.0069615683,
-0.003616525,
-0.03743863,
0.016172558,
-0.0004997366,
-0.024627276,
0.008984754,
-0.00055104337,
-0.010464977,
-0.016741376,
-0.0043049254,
-0.037542053,
0.0053035906,
0.0329915,
0.0048543527,
-0.001746856,
0.03749034,
-0.0027164337,
0.020128435,
0.028440949,
-0.001525469,
0.023282794,
-0.0038653833,
-0.017633388,
0.014104125,
-0.012675613,
-0.021188507,
-0.029371742,
-0.017206773,
0.021628048,
-0.024666058,
-0.0008790839,
0.005141994,
-0.01396192,
0.0009356426,
0.015474461,
0.00038419518,
-0.017103352,
-0.043281954,
-0.011337596,
0.024006747,
-0.001092391,
0.009042929,
-0.00218155,
0.0025467577,
-0.009230381,
0.009055857,
-0.0060146144,
-0.00080959743,
0.044600576,
-0.0017533199,
-0.042454578,
0.017943652,
0.01632769,
-0.028130684,
0.0036132932,
0.014362679,
-0.016069137,
0.0019246119,
0.022002952,
-0.010943301,
0.0029830677,
-0.03495651,
-0.01168018,
-0.00357451,
0.007549779,
0.018654676,
-0.0012636831,
-0.0009873534,
-0.02268812,
0.016340617,
0.007026207,
-0.009534181,
0.017167991,
-0.01027106,
-0.015383967,
0.027174033,
0.022377856,
-0.019921592,
0.027018901,
0.0016321226,
0.035396054,
0.0012580272,
0.010852807,
-0.018370267,
-0.030897211,
-0.044264458,
-0.013367246,
-0.009476007,
-0.003361203,
-0.023786975,
-0.011150144,
0.0046022628,
-0.02527366,
-0.0065705054,
-0.0014584066,
-0.0051096748,
0.012074475,
0.02257177,
-0.010477904,
0.008377152,
0.009023537,
-0.011137216,
-0.0014341671,
-0.0002498683,
-0.0077760136,
0.017193846,
-0.010316308,
0.0017662476,
-0.028337527,
-0.014039487,
-0.015383967,
0.038369425,
-0.008053959,
-0.019960374,
-0.0025144385,
-0.0023673857,
0.0092627,
0.008254339,
-0.011777138,
0.0052971267,
-0.007911755,
0.0012741868,
-0.0032561654,
-0.008312513,
0.018719316,
0.0023754656,
-0.0055136657,
-0.022106374,
0.025131457,
0.0016216189,
0.030199116,
-0.003448465,
-0.0038169045,
0.03423256,
0.006389518,
0.010510223,
-0.010180566,
0.014194619,
0.007556243,
-0.008092742,
-0.014000704,
-0.015112486,
0.0014131597,
-0.006111572,
-0.016107919,
-0.021162651,
0.014724654,
-0.030354248,
0.03247439,
-0.02330865,
-0.00006630498,
-0.029992273,
0.00847411,
0.0056914217,
0.001089159,
-0.01908129,
-0.0058821053,
-0.0036843955,
-0.018021218,
0.0069098575,
-0.0043404764,
-0.009101103,
0.0013121619,
-0.010193494,
-0.025558071,
0.009036465,
0.008196164,
-0.017775593,
-0.011331133,
0.03963634,
0.0012103562,
-0.014931498,
0.010549006,
-0.0023819294,
-0.012850137,
-0.03045767,
-0.002485351,
0.0049965577,
0.011137216,
0.0021702382,
-0.01621134,
-0.03006984,
0.03462039,
-0.0020215698,
0.02021893,
0.005497506,
0.0010608797,
0.0065478818,
0.006034006,
-0.04108424,
0.020425772,
-0.00892658,
-0.010982084,
0.021809036,
-0.01705164,
-0.0024966628,
0.0028457108,
-0.0012491394,
-0.0100125065,
-0.0002797636,
-0.009547109,
0.0016200029,
0.036094148,
0.025441721,
0.03112991,
0.01525469,
0.011040259,
0.008144453,
-0.023412071,
-0.0009542261,
-0.00889426,
0.008112134,
0.0023835453,
-0.024084313,
-0.046203613,
-0.02206759,
0.016004497,
-0.022339072,
-0.006412141,
0.0046378137,
0.020128435,
0.040153448,
0.028001407,
0.021951241,
-0.0024772712,
-0.019960374,
0.010704138,
0.01458245,
-0.022106374,
0.00038520517,
-0.01345774,
0.0036779316,
0.012701469,
0.005187241,
0.0045667114,
0.01891323,
-0.026411299,
-0.010199958,
-0.011725428,
-0.0073493994,
0.035240922,
-0.005061196,
0.01902958,
0.008842549,
0.0025095905,
-0.019055435,
-0.007116701,
-0.004014052,
0.017517038,
0.014039487,
-0.009463079,
0.011447482,
-0.0068581467,
-0.0014446708,
-0.011240639,
-0.01396192,
-0.006993888,
0.010807561,
0.0072653694,
0.012313638,
0.031285044,
0.005985527,
0.0272516,
0.010251669,
-0.010807561,
-0.04131694,
-0.0048608165,
-0.01981817,
0.02973372,
0.008112134,
-0.013470667,
0.025286589,
0.029888852,
0.008719736,
0.00031208285,
-0.026359588,
0.011098433,
0.004321085,
-0.01384557,
-0.023412071,
-0.002094288,
0.0017953349,
0.021123867,
0.029940562,
0.015681304,
0.00060558214,
-0.013638727,
0.005096747,
0.0005187241,
-0.0032981804,
0.0156166665,
0.04364393,
0.035034075,
0.011395771,
0.00060962205,
0.01266915,
0.01292124,
-0.01908129,
-0.0076596644,
0.018680532,
0.006551114,
0.01975353,
0.004030212,
-0.028078973,
-0.00076435047,
0.0023447622,
0.011402234,
-0.002621092,
0.01908129,
0.011421626,
0.0023609218,
-0.010193494,
0.0056429426,
-0.024847047,
-0.00672887,
0.0053391415,
0.0011012788,
0.0029103493,
0.0068646106,
-0.022985457,
0.02134364,
-0.028182395,
-0.010452049,
0.004285534,
0.007847116,
0.0019149161,
-0.02859608,
-0.009980187,
-0.003445233,
-0.0087714465,
0.020516265,
0.0042176633,
-0.019598398,
-0.000568415,
-0.013179794,
-0.002572613,
-0.03045767,
-0.019197641,
0.02567442,
-0.02978543,
-0.01740069,
-0.0048995996,
0.011770674,
0.0037005553,
0.010910982,
-0.02696719,
0.039170943,
-0.015112486,
-0.019223496,
0.02336036,
-0.0014115437,
-0.002789152,
0.0035906697,
0.022196867,
0.029526874,
-0.0151641965,
-0.025635637,
-0.0078083333,
-0.004844657,
-0.013037589,
-0.0040754587,
-0.020141363,
-0.014608305,
-0.009307947,
0.01581058,
0.04436788,
-0.010044826,
-0.017374834,
0.0016111151,
-0.02696719,
-0.0021055997,
-0.029190755,
-0.002099136,
-0.026708636,
0.023942107,
-0.006534954,
0.007077918,
-0.039377786,
0.01491857,
-0.0067482614,
0.02369648,
-0.012100331,
-0.009624676,
0.008370688,
0.027742852,
-0.00017492799,
0.009792736,
-0.016857726,
-0.011208319,
-0.034491114,
0.030250827,
-0.012811354,
-0.01142809,
0.0040722266,
0.007510996,
-0.017685099,
-0.04126523,
-0.015319329,
0.007330008,
0.024123095,
-0.010536078,
-0.029139044,
-0.030276682,
0.010620109,
0.018008292,
0.012171433,
-0.018667605,
0.0064703156,
0.0137162935,
0.0075303875,
-0.02139535,
-0.0118547045,
0.036016583,
-0.031362608,
0.0017937189,
-0.0011028948,
0.020348206,
0.021214362,
0.020955808,
-0.01424633,
-0.02347671,
-0.0051226025,
-0.02054212,
-0.024291156,
0.00082737306,
-0.007995785,
0.025299516,
0.021408277,
0.03715422,
-0.0029555962,
0.0029927634,
0.0010738074,
-0.005461955,
0.0028877258,
-0.009547109,
0.020451628,
-0.014711726,
-0.0030574019,
0.013431884,
-0.00052155205,
0.027794562,
-0.026786203,
0.013367246,
0.025066817,
-0.0010334083,
-0.025739059,
-0.0039073983,
-0.049900938,
0.0043501724,
0.004712148,
-0.0078083333,
0.023967963,
-0.02089117,
-0.0058594816,
0.032939788,
0.0063151834,
-0.0005898265,
-0.013819715,
0.020516265,
-0.009676387,
0.035085786,
-0.007284761,
-0.017943652,
-0.0389641,
0.0166121,
0.0018664373,
-0.019236423,
0.019740604,
-0.008028104,
0.012274855,
0.030250827,
0.00496747,
0.021615122,
0.030276682,
-0.021188507,
-0.010742921,
-0.012029229,
-0.029862996,
0.001615963,
-0.005423172,
-0.001268531,
-0.0077954056,
0.0064800116,
-0.0050515,
-0.012352421,
0.014556594,
-0.034749668,
-0.005933816,
0.0002757237,
-0.007711375,
0.017103352,
-0.022804469,
0.014026559,
0.03485309,
0.0005736668,
-0.032164127,
-0.0077436944,
-0.004834961,
-0.008034568,
0.02859608,
0.0043824916,
-0.016094992,
-0.032060705,
0.014698799,
-0.010141783,
0.013276752,
-0.021240218,
0.026708636,
0.010445585,
0.008551676,
-0.006156819,
-0.017103352,
-0.018305628,
0.004498841,
-0.03226755,
-0.029087333,
-0.02065847,
-0.021291928,
-0.008506429,
0.016094992,
-0.023386216,
0.019003725,
-0.010077145,
0.0016094991,
-0.025312444,
-0.021821965,
0.010096537,
0.0013250896,
0.0037458022,
0.016987003,
-0.001047952,
0.026501793,
-0.010484368,
0.0037361064,
0.009126958,
0.005639711,
-0.004741235,
0.033534463,
-0.014970281,
-0.009295019,
0.01649575,
0.0053940844,
0.015784726,
0.0048931357,
-0.0020296494,
-0.002968524,
-0.009398441,
0.0012717629,
0.030380104,
0.018900303,
-0.023709409,
0.011951662,
-0.019585472,
-0.0023657698,
-0.020580905,
0.0087262,
-0.019404484,
-0.017361905,
0.010477904,
-0.013638727,
-0.0021298393,
-0.0063507343,
0.004925455,
-0.002800464,
-0.014996137,
-0.004233823,
-0.031724583,
0.019585472,
0.02302424,
0.021201434,
-0.01615963,
0.0079634655,
-0.029061478,
-0.037645474,
0.009773344,
0.0070908456,
-0.035990726,
-0.006583433,
-0.0015602122,
0.005074124,
0.00082090916,
-0.028130684,
0.011156608,
-0.009999579,
0.0034161457,
-0.007679056,
-0.006599593,
0.035964873,
0.003050938,
-0.014013631,
0.001436591,
-0.00013685186,
0.0064541562,
-0.020193074,
0.015177124,
-0.007918218,
-0.024523854,
0.021718543,
-0.019210568,
0.014815149,
-0.010568398,
0.012171433,
-0.007556243,
-0.0067030145,
-0.022662265,
0.026411299,
0.02522195,
0.00045004569,
-0.0011190544,
0.008655097,
0.0041271695,
0.008887797,
0.0014802221,
-0.008189701,
-0.010600717,
-0.023088878,
-0.019520832,
0.008435327,
-0.009896157,
0.034878943,
0.021653904,
0.005106443,
0.015228835,
0.004964238,
-0.062311534,
-0.005985527,
0.024110168,
-0.0025128224,
0.031233333,
0.026217382,
-0.0069551044,
0.0070649902,
0.011395771,
0.008125062,
-0.012966487,
-0.0078083333,
0.0016789855,
0.006421837,
0.027096467,
-0.0073429355,
-0.01030338,
-0.014892715,
0.0051549217,
-0.01072353,
-0.016133774,
0.0116672525,
-0.00027814764,
0.0035292632,
-0.020955808,
0.032241695,
0.007950538,
-0.018564183,
0.008745591,
-0.018034147,
-0.015784726,
-0.0087262,
0.00130893,
0.0056946534,
0.013936064,
-0.00017815991,
0.016831871,
0.027225744,
-0.006922785,
-0.025415866,
0.0070585264,
-0.0130893,
0.026734492,
0.019908663,
0.0185254,
0.010607181,
0.011098433,
0.012688541,
-0.004007588,
0.0063313427,
-0.002314059,
0.010154711,
0.012591584,
0.012236072,
-0.029009767,
-0.0067353337,
0.004941615,
-0.007026207,
0.0026792665,
-0.02882878,
0.000060901606,
-0.03399986,
0.034387693,
0.003616525,
-0.012126186,
-0.003050938,
-0.011971054,
-0.008668025,
0.0091657415,
-0.0032480855,
0.013134547,
-0.0070197433,
-0.025894191,
0.022804469,
-0.012850137,
0.004450362,
0.017672172,
-0.005762524,
-0.015138341,
0.010936838,
0.1811947,
0.0035551186,
-0.0039785006,
0.0021104477,
0.010865735,
0.021912457,
0.022778613,
-0.013599944,
0.01897787,
0.015797654,
0.0025693811,
-0.009191598,
0.012197289,
0.0032270781,
0.0049771657,
-0.0037813534,
-0.019727675,
-0.019727675,
0.020567976,
-0.0065769693,
0.021304855,
-0.015021992,
-0.015552027,
-0.008286658,
0.03407743,
0.028699502,
-0.010264597,
-0.0062634726,
0.01981817,
0.0049448465,
0.019585472,
0.009605284,
-0.0074463575,
0.015836436,
-0.005768988,
-0.00785358,
-0.025118528,
-0.041291084,
0.013755077,
0.020580905,
-0.009993115,
0.0015553643,
-0.043488797,
-0.012203752,
0.015603739,
0.018447833,
-0.006156819,
-0.014259257,
-0.004492377,
0.008267267,
-0.02144706,
-0.02612689,
0.009760416,
0.04025687,
-0.0059661353,
0.0014600225,
0.036895666,
0.013496523,
-0.005468419,
0.007355863,
-0.0063927495,
0.0131151555,
-0.033844728,
0.03389644,
-0.0036973234,
0.010329235,
-0.030923067,
-0.014931498,
-0.021925386,
-0.010736458,
-0.0035260313,
-0.023825757,
-0.010167639,
0.012449379,
0.020425772,
-0.0017226165,
0.018654676,
-0.00008837297,
0.0027859202,
0.015177124,
-0.018253917,
0.008855477,
-0.007885899,
-0.006205298,
-0.007420502,
-0.03619757,
0.0057786833,
-0.0013711445,
-0.012449379,
0.008157381,
-0.0135094505,
-0.01570716,
0.014647088,
0.008855477,
-0.002309211,
0.0016256587,
0.00020926721,
0.017271413,
-0.030483525,
-0.0039558774,
-0.015190052,
0.058226377,
0.019003725,
-0.00349048,
0.012016301,
-0.005668798,
-0.0012564112,
0.0011037027,
-0.005794843,
0.010245205,
0.019507905,
-0.05471004,
0.0053488375,
0.0028117755,
-0.02849266,
0.021615122,
0.021227289,
-0.023412071,
0.011001476,
0.008887797,
0.006321647,
-0.034516968,
0.0023237548,
0.007976393,
-0.0058303946,
-0.014685871,
-0.039817326,
0.0145436665,
-0.0035615824,
-0.032913934,
-0.0012152041,
-0.03231926,
0.011175999,
0.022532988,
0.00026037203,
-0.0001789679,
0.03012155,
-0.037309352,
0.010090073,
0.027897984,
0.0068193637,
-0.018512473,
0.011673717,
-0.014401462,
0.002614628,
-0.013910209,
-0.0023382984,
0.019055435,
-0.0042176633,
-0.0019052203,
-0.040127594,
-0.0035518866,
0.016405256,
0.001787255,
0.02032235,
-0.005801307,
-0.021576338,
-0.0442386,
-0.0072201225,
0.028647792,
-0.00011311741,
0.029501019,
0.00038217523,
-0.026088106,
-0.011725428,
0.01621134,
-0.1611309,
-0.00080515357,
0.020141363,
-0.037981592,
0.011647861,
0.008047496,
0.021990024,
0.018318556,
-0.012035692,
0.019378629,
0.032784656,
0.023722336,
-0.033431042,
-0.0019278438,
-0.011486265,
0.008532285,
-0.0092627,
0.030095695,
0.020037942,
0.01105965,
0.030638658,
-0.027742852,
0.016120847,
-0.028777068,
0.0137162935,
-0.0062570088,
0.0040366757,
0.015138341,
0.022933746,
-0.012804891,
0.0095794285,
-0.0066254484,
0.0349048,
-0.025997613,
0.02443336,
-0.010251669,
-0.010620109,
-0.015797654,
-0.017193846,
-0.0033450434,
0.0068322914,
-0.009947868,
0.0050062533,
-0.00014856759,
-0.0116866445,
0.026553504,
-0.015138341,
-0.013871426,
0.020968735,
-0.00095261016,
0.03575803,
-0.0060598613,
0.03169873,
0.010187031,
0.0036326847,
0.0067417976,
0.01441439,
0.014905643,
0.009553573,
-0.010684747,
-0.0006625448,
-0.025532214,
0.020076724,
0.004411579,
0.02888049,
-0.03749034,
-0.0023463783,
0.022817397,
-0.01976646,
0.0012968102,
-0.029009767,
-0.006538186,
-0.0061244997,
-0.023851613,
0.019262278,
0.00793761,
-0.0049545425,
0.017297268,
-0.023063023,
-0.008913652,
-0.023256939,
0.003445233,
-0.029656153,
0.0019294597,
-0.03319834,
0.0035098717,
0.02021893,
0.02854437,
0.011175999,
-0.009282092,
0.025739059,
-0.024006747,
-0.0028715662,
-0.0053488375,
0.0075303875,
0.011195391,
0.009980187,
0.005416708,
-0.0022946673,
0.003012155,
0.026139816,
-0.030224971,
-0.042377014,
-0.010826952,
0.025260733,
-0.010180566,
0.0025241342,
-0.0020409613,
0.019120073,
-0.0053391415,
0.0125140175,
0.0137162935,
-0.00021088317,
0.018602965,
-0.018215135,
0.0034678564,
0.02612689,
-0.0056591025,
0.013638727,
-0.004030212,
0.035034075,
0.0005405396,
0.0033094923,
-0.019520832,
0.024989251,
-0.019249352,
-0.12948388,
-0.031285044,
0.008603387,
0.0061212676,
0.0011497576,
0.016870653,
-0.003144664,
0.016935293,
0.0009033233,
0.026993046,
-0.0022930515,
-0.012371812,
0.009993115,
0.0016644419,
0.023774046,
-0.024743624,
-0.00889426,
-0.014879787,
-0.03557704,
0.014349751,
0.010561934,
-0.015474461,
0.006017846,
-0.011240639,
-0.006357198,
0.00723305,
-0.009230381,
-0.0055136657,
0.0031963747,
0.009320875,
0.012695005,
-0.015526172,
0.0035421909,
-0.010607181,
-0.013936064,
-0.004718612,
-0.014440245,
-0.012139114,
0.015448606,
-0.0044697537,
-0.000743343,
0.017685099,
0.026088106,
0.0022801238,
0.0185254,
-0.0068258275,
-0.032681234,
0.0070843818,
0.021640977,
-0.012281318,
-0.010464977,
0.008034568,
-0.05072831,
0.010962693,
-0.01168018,
-0.012785499,
-0.015461533,
0.027897984,
-0.014724654,
-0.0004411579,
0.0034096818,
0.015836436,
-0.011544439,
0.012772571,
0.011318205,
-0.004889904,
-0.008370688,
-0.016314762,
0.005484578,
-0.03247439,
-0.015177124,
0.007388183,
0.006761189,
-0.017361905,
-0.021886602,
0.02769114,
-0.011602614,
-0.018758098,
-0.0027245136,
-0.017866086,
-0.016689666,
0.0033773626,
0.019352773,
0.0006706246,
0.026837913,
0.024808263,
0.0025402938,
0.020761892,
-0.0069486406,
-0.018874448,
-0.005280967,
0.02696719,
0.044057615,
-0.00080515357,
-0.020697253,
0.0073106163,
-0.004851121,
-0.010607181,
0.035964873,
-0.0026857303,
-0.026385443,
-0.029656153,
-0.040127594,
0.021317784,
0.015862292,
-0.012378276,
-0.010717066,
-0.021291928,
-0.010697675,
-0.009088175,
0.017646316,
-0.000114834365,
-0.009172206,
0.004873744,
-0.00830605,
-0.0045602475,
-0.018008292,
-0.020309422,
0.025570998,
0.0060146144,
0.024368722,
0.025183167,
-0.0074851406,
0.0043663317,
0.0031931428,
0.020167219,
-0.020619687,
0.0064444602,
-0.0149573535,
0.0017129207,
-0.013729221,
-0.00003491995,
0.013483595,
-0.019831097,
-0.003836296,
0.035318486,
-0.02448507,
-0.016909437,
0.0016208108,
0.031336755,
0.013638727,
0.04610019,
-0.009999579,
-0.030328393,
0.026411299,
0.010322771,
-0.0047670905,
-0.008066887,
-0.03562875,
0.00988323,
-0.012817819,
-0.016069137,
0.015552027,
0.009870302,
0.005662334,
-0.036171716,
-0.006198834,
0.00023229468,
-0.00090897916,
-0.0069615683,
0.0031608236,
-0.028983911,
-0.00731708,
0.043152675,
0.007672592,
0.011815921,
-0.0036035974,
-0.01458245,
-0.023489637,
0.011796529,
-0.00434694,
-0.0074786767,
-0.028802924,
0.011699572,
0.015888147,
-0.013328463,
0.020929953,
-0.0060921805,
0.009107567,
-0.001178845,
0.0079634655,
0.011408699,
-0.005662334,
0.008571068,
-0.011240639,
0.02663107,
0.048323758,
0.013076372,
-0.009236844,
0.005529825,
-0.0145436665,
-0.0005017565,
0.015047847,
0.0019213799,
0.0020248017,
0.014362679,
0.016172558,
0.006851683,
0.0027762244,
0.0043275487,
0.019443266,
0.020361133,
-0.007459285,
-0.013910209,
-0.004330781,
-0.024769481,
-0.014375607,
0.029578587,
-0.028078973,
-0.020619687,
-0.0104068015,
-0.00019361256,
-0.0020021782,
0.003755498,
0.013406029,
-0.003181831,
-0.0153710395,
0.02297253,
0.0056138556,
0.008648634,
-0.0035615824,
0.008499965,
0.008396544,
0.021291928,
0.000131196,
-0.018253917,
0.005025645,
-0.007711375,
0.017723883,
-0.015047847,
0.036843956,
-0.010128856,
0.0032206143,
-0.009120495,
0.0019456194,
-0.026682781,
-0.020904098,
-0.020813603,
0.01599157,
0.018783953,
-0.0030881052,
0.06737919,
-0.004957774,
-0.019469121,
0.0033353476,
-0.01486686,
0.008234947,
0.016133774,
0.013218577,
-0.00095665007,
-0.017478256,
0.0014058878,
0.008222019,
0.028466804,
-0.023774046,
-0.03045767,
0.026152745,
-0.009844447,
0.027406732,
-0.02443336,
-0.0028634863,
0.041575495,
-0.020865314,
0.04356636,
0.0033288838,
-0.010141783,
-0.01005129,
0.034335982,
0.006021078,
-0.0064412286,
-0.028182395,
-0.0049836296,
0.030147405,
-0.04116181,
-0.008887797,
0.019585472,
-0.042583857,
0.006502635,
-0.033069067,
-0.0045570154,
0.010568398,
-0.02054212,
0.010678283,
0.0064864755,
-0.0006673927,
-0.0025839247,
-0.02139535,
-0.03568046,
-0.028777068,
-0.01862882
] |
Type 2 immune responses are defined by the cytokines interleukin-4 (IL-4), IL-5, IL-9 and IL-13, which can either be host protective or have pathogenic activity. Type 2 immunity promotes antihelminth immunity, suppresses type 1-driven autoimmune disease, neutralizes toxins, maintains metabolic homeostasis, and regulates wound repair and tissue regeneration pathways following infection or injury. Nevertheless, when type 2 responses are dysregulated, they can become important drivers of disease. Type 2 immunity induces a complex inflammatory response characterized by eosinophils, mast cells, bas | [
-0.014762231,
0.007263852,
-0.009257339,
-0.018775266,
-0.035101015,
0.015413698,
-0.0139804715,
-0.0084234625,
-0.0018517936,
-0.026215013,
0.018032594,
-0.0070358384,
0.010149849,
-0.010188936,
-0.0010252454,
0.014931613,
0.05120527,
0.021550512,
-0.012508158,
0.033355087,
-0.030123813,
0.0069902358,
0.004576552,
-0.019374615,
-0.008983724,
0.010586331,
-0.0006201147,
-0.059257396,
-0.01983064,
-0.006345284,
0.013602621,
-0.041954443,
-0.007029324,
0.014592851,
-0.0034723165,
-0.03484043,
0.015439757,
0.0045179203,
0.015283405,
0.0179023,
0.012560274,
0.021667777,
0.0069967504,
0.006120528,
0.002542348,
0.007967436,
0.025055403,
-0.016039105,
-0.009876233,
-0.0014747573,
0.011778515,
-0.011530957,
-0.0077003343,
0.010697081,
-0.023022827,
-0.0077394224,
0.0038599393,
0.006328997,
0.009407177,
-0.044873014,
-0.021550512,
-0.0049413736,
-0.026371365,
-0.009087958,
0.006009779,
0.0047817645,
-0.00051343703,
0.010768741,
-0.015517932,
0.001376223,
0.022527713,
0.044039138,
-0.009459294,
-0.0077980543,
0.012859949,
-0.03017593,
-0.0014780146,
-0.0058436547,
-0.010175907,
-0.0038436526,
0.018775266,
-0.04221503,
-0.009680793,
0.027153125,
0.02102934,
0.0015708486,
0.00700978,
0.013263859,
-0.017837154,
-0.012247571,
-0.01041695,
0.0002229237,
0.021772012,
0.038045645,
-0.015140082,
0.033146616,
0.013967442,
0.038436525,
-0.016651485,
-0.006475577,
-0.005651472,
-0.01557005,
-0.00080700417,
-0.020299697,
-0.03499678,
0.004827367,
0.008228023,
-0.005602612,
0.02780459,
-0.002566778,
-0.015739432,
0.037133593,
-0.008293169,
-0.033537496,
0.01730295,
0.022697093,
0.007237793,
0.0051628724,
0.0066905613,
-0.015140082,
0.004221503,
0.022853445,
0.02785671,
-0.004153099,
0.025980486,
-0.009947894,
-0.004032578,
-0.020156374,
-0.029446287,
0.0082149925,
0.0063680853,
0.01732901,
0.02199351,
-0.008123788,
0.0013021188,
0.031009806,
-0.02295768,
-0.013003272,
0.0056677586,
0.003879483,
0.02510752,
0.022110773,
0.001561891,
-0.0048697125,
0.010644963,
0.008078185,
0.036143363,
-0.0012947897,
-0.0053485404,
0.009895776,
-0.011947896,
-0.03129645,
0.001388438,
-0.009237795,
-0.00067874667,
0.028482117,
0.009504897,
0.038644996,
-0.0389577,
-0.024039116,
-0.00075447967,
-0.038280174,
0.00019147008,
-0.003885998,
0.0070162946,
0.018710118,
0.01235832,
0.015309463,
0.0040879524,
0.008638446,
-0.014084706,
0.01986973,
-0.006872972,
0.025589606,
-0.021081457,
0.029811108,
-0.003671014,
0.01653422,
-0.01480132,
-0.010638448,
-0.020729665,
-0.0035244338,
0.02041696,
-0.00991532,
-0.017798066,
-0.0038990271,
0.025758987,
0.013772002,
0.0042736204,
-0.008221508,
0.012657994,
0.020755723,
-0.010736168,
-0.018631943,
-0.6254079,
-0.016208487,
0.032651503,
-0.01216288,
0.001378666,
0.01615637,
0.002635182,
-0.009517926,
-0.009224766,
0.017172657,
0.008703593,
0.0058990293,
0.010247569,
-0.01441044,
-0.013022816,
-0.04846911,
-0.021094486,
-0.023426736,
-0.011094475,
-0.018162888,
0.0078110835,
0.010149849,
-0.0043485393,
0.016117282,
-0.00994138,
-0.008104243,
0.017107511,
-0.013889266,
0.020104257,
0.044039138,
-0.021289926,
0.035074957,
0.015322492,
0.011459297,
0.044664547,
0.007524438,
-0.031166159,
0.022071686,
0.022996768,
0.027700357,
-0.016794806,
-0.01245604,
0.017185686,
-0.0069250893,
-0.009967438,
0.016886013,
0.014527704,
0.03194792,
0.023283415,
-0.011107504,
0.010456038,
-0.0009201965,
-0.016586337,
0.0042149886,
0.0350489,
0.009100988,
0.028508175,
-0.02433879,
0.0040586363,
0.0037459326,
0.0068664574,
0.033641733,
-0.014866466,
-0.012123792,
-0.009472324,
0.014514674,
-0.0066840467,
-0.009016297,
-0.00816939,
0.0067817667,
0.016221516,
0.015114023,
-0.006768737,
0.00023208495,
0.015400669,
0.039061934,
0.007257337,
-0.013772002,
-0.012736171,
0.019361585,
0.0046970737,
-0.0055342084,
-0.0111856805,
-0.002040719,
0.029706873,
-0.016612396,
-0.008332257,
0.025081461,
-0.011257341,
0.0104104355,
0.018032594,
0.004123783,
-0.01885344,
-0.026814362,
-0.028690586,
0.04617595,
0.00037703625,
0.0005822482,
-0.00004310876,
-0.011758971,
-0.006514665,
-0.0016775263,
-0.0005932417,
0.0075635263,
0.014436498,
0.00021396604,
-0.0497981,
0.014371351,
0.037029356,
-0.017798066,
0.015140082,
0.0049804617,
-0.0097329095,
-0.01090555,
0.03854076,
-0.01480132,
0.0206124,
0.004612383,
-0.0009576558,
-0.01361565,
0.02432576,
-0.008684048,
0.0048501682,
-0.010964181,
-0.0036873005,
0.025628693,
-0.017016307,
-0.020377873,
-0.010723139,
-0.028742703,
-0.009498382,
0.019778524,
0.0072703664,
0.0084234625,
-0.0010456038,
0.0031416973,
0.05467107,
-0.010495125,
-0.0063974014,
-0.030384399,
-0.014215,
-0.027726416,
-0.0065863268,
-0.024429996,
0.012156365,
0.0018876243,
-0.021003282,
0.009022811,
0.03408473,
-0.0056742732,
0.010625419,
-0.0028664528,
-0.013915325,
0.0051759016,
0.026671039,
-0.007140073,
0.020013051,
-0.01730295,
0.00019035037,
-0.0073811156,
0.005436488,
0.007218249,
0.012241056,
0.014749202,
-0.031973977,
0.0021237808,
-0.009355059,
0.010488611,
-0.006775252,
-0.052065205,
-0.018827382,
-0.005876228,
-0.03194792,
0.027074948,
0.01517917,
0.0065179225,
-0.014618909,
-0.0017443016,
0.005403915,
0.013433239,
-0.013472328,
-0.008286654,
0.0046970737,
-0.0035602646,
0.025029344,
-0.018762236,
0.03718571,
-0.017407186,
0.011309459,
0.053837195,
-0.009355059,
-0.0006123785,
-0.006775252,
0.025732927,
-0.018110769,
-0.013719885,
0.016768748,
0.0011701968,
0.019726407,
0.0024592862,
-0.011550502,
-0.023830645,
-0.004947888,
-0.012319232,
0.0019218263,
-0.03734206,
0.0012312718,
-0.005387628,
0.030488633,
0.008944635,
-0.0048338817,
-0.025563547,
-0.014723144,
-0.0053355107,
0.032781795,
0.024625435,
-0.007472321,
0.0069511477,
-0.007257337,
-0.009120531,
-0.0013526074,
0.0005093654,
0.007439748,
-0.005387628,
-0.022840416,
0.028768761,
0.003938115,
-0.002436485,
-0.025029344,
-0.013302946,
-0.00018872171,
-0.018201975,
0.009563529,
-0.0028045634,
0.010521185,
0.032182448,
0.0023273642,
-0.0001937095,
0.043465845,
0.0033061926,
0.01293161,
-0.012397408,
-0.0066188998,
0.0013330634,
0.0022899047,
0.003465802,
0.030618927,
0.003534206,
-0.014254088,
0.007726393,
-0.015882755,
-0.005648215,
-0.0068599423,
-0.030671043,
-0.0077915397,
-0.008162876,
0.0031400686,
0.0013257344,
0.04065151,
0.039478872,
0.018175917,
-0.024781786,
0.008377859,
-0.0037850204,
0.008749195,
-0.0006775252,
-0.0066254144,
0.0017866469,
-0.0088273715,
-0.026710128,
-0.032338798,
0.0068664574,
0.03695118,
-0.018736178,
0.033928376,
0.011205224,
0.007257337,
-0.0075439825,
0.006488607,
0.005208475,
-0.01731598,
-0.024091233,
0.027127067,
0.017980477,
0.0069381185,
-0.015921842,
-0.036612418,
-0.011811088,
0.0027980488,
0.011837147,
-0.0011107505,
0.01615637,
0.018175917,
-0.006671017,
0.00291857,
0.007589585,
0.043283436,
-0.02044302,
0.021081457,
-0.027283419,
-0.0012703597,
0.00156922,
-0.011661251,
0.009348544,
0.023244325,
0.016416956,
-0.008338772,
-0.01020848,
-0.02861241,
-0.013394152,
-0.00013436498,
-0.006377857,
0.007257337,
-0.045446306,
0.016078195,
0.015283405,
-0.0035960951,
0.00043444673,
0.031609155,
-0.016560279,
-0.008208478,
-0.035987012,
0.018540738,
0.011322488,
0.017146599,
0.011055387,
0.011830633,
0.014553762,
0.01674269,
0.008527697,
-0.0064820917,
-0.013407181,
0.02783065,
-0.024117291,
-0.0030928373,
-0.00013426317,
0.014944642,
0.01022151,
0.014918583,
0.011680795,
0.0033420234,
-0.001310262,
-0.007824113,
0.008664505,
0.021850187,
0.0024283414,
0.024273643,
0.016443016,
0.029029349,
-0.008241052,
-0.011504899,
0.008351801,
0.001698699,
-0.03679483,
0.012351805,
0.029133582,
0.0031938145,
0.03682089,
-0.0148534365,
-0.016182428,
-0.009205222,
0.013407181,
0.0061465865,
-0.015035847,
0.020078199,
0.019127058,
0.01986973,
0.0023078201,
-0.0036188965,
-0.0022801328,
0.0006347727,
0.023048885,
-0.007980465,
-0.008377859,
0.015218258,
0.002566778,
0.0061531016,
-0.044899072,
0.014188941,
-0.015895784,
-0.014631938,
-0.00360261,
-0.011960926,
-0.007745937,
-0.006573297,
-0.015100994,
0.017941387,
-0.01344627,
-0.030306224,
-0.017654743,
-0.00914659,
-0.0018876243,
-0.011042357,
-0.0069772066,
0.016195457,
-0.029941402,
0.0061237854,
0.02453423,
0.0024429995,
0.022110773,
0.0036742713,
-0.019622171,
-0.0015952786,
-0.011446266,
0.002635182,
-0.010521185,
0.0052377908,
-0.02960264,
0.027074948,
-0.00057695503,
0.0058013094,
-0.009954409,
-0.020912075,
0.002182413,
-0.0026384394,
-0.013472328,
-0.0018811096,
0.007954407,
-0.0013460927,
0.008736166,
0.020013051,
0.0054104296,
-0.00497069,
-0.026671039,
-0.020390902,
-0.015830636,
-0.021876246,
0.0008697078,
0.001354236,
-0.016260605,
0.0048892563,
0.009283398,
-0.002786648,
-0.022866474,
0.028273648,
-0.0040097763,
0.0045602657,
0.0051140124,
0.0069902358,
0.02999352,
0.0042931642,
-0.0065342095,
0.020925105,
-0.021667777,
-0.011882749,
-0.01751142,
-0.004680787,
-0.00962216,
-0.036247596,
0.006159616,
-0.010671021,
-0.012697083,
-0.0023420223,
-0.009654734,
-0.02121175,
0.0019478849,
0.0022084715,
-0.02122478,
-0.020872988,
0.014514674,
-0.012149851,
0.02059937,
-0.0069772066,
-0.0042931642,
0.0018469077,
0.011459297,
-0.007335513,
-0.011895779,
0.017719889,
-0.03205215,
-0.019140087,
0.038827404,
0.011426723,
0.016651485,
0.004319223,
-0.013772002,
-0.019700348,
0.010671021,
-0.018827382,
-0.035205252,
-0.00024328203,
-0.0119283525,
0.030097753,
0.029133582,
0.020859959,
0.0008379488,
0.0073876306,
0.006944633,
0.013524445,
0.011850176,
-0.01927038,
0.011009784,
-0.024260614,
-0.0010846917,
-0.0071596173,
-0.0038273658,
0.0067426786,
-0.004159614,
0.01904888,
0.009557014,
0.00085586414,
-0.027387653,
-0.026762245,
-0.020130316,
-0.01890556,
0.03283391,
-0.0014144967,
0.010970696,
-0.02684042,
-0.00022760611,
-0.0021872988,
0.011596104,
0.007140073,
0.007824113,
0.018788295,
-0.010117275,
0.03244303,
-0.014188941,
0.0001583878,
-0.009283398,
0.008514668,
0.014188941,
-0.0024283414,
0.011159621,
0.0071075,
0.0005846912,
-0.008221508,
-0.0019039109,
0.016104253,
0.0011140078,
-0.03213033,
-0.030410457,
-0.028351823,
-0.01828015,
-0.009973953,
-0.006052124,
-0.023986997,
-0.021654747,
-0.022801328,
0.0003933229,
-0.03332903,
0.016586337,
-0.020338785,
-0.0071075,
0.03408473,
-0.018436503,
0.0035114046,
-0.03176551,
0.009758969,
0.02978505,
0.00088192284,
0.00023086346,
-0.004983719,
-0.0073811156,
-0.00934203,
0.02161566,
0.032886032,
-0.0006482092,
-0.026228042,
0.017420216,
-0.0015407184,
0.03541372,
-0.015713373,
0.011361577,
0.008938121,
0.021498395,
-0.016755719,
-0.013159624,
-0.02843,
0.016495133,
-0.006149844,
0.008996753,
-0.008820857,
0.017459303,
-0.02276224,
0.018032594,
-0.02393488,
0.016690573,
-0.000019238621,
-0.014866466,
-0.014436498,
-0.04943328,
0.004687302,
-0.01809774,
0.014944642,
0.037759,
0.00013823305,
0.034371372,
0.029055407,
0.00039291574,
-0.0070879557,
0.021524454,
-0.0031351827,
0.034345314,
-0.0108143445,
0.00015940571,
-0.004143327,
0.0024136836,
0.020664519,
-0.0318958,
-0.0054886057,
0.0008330628,
-0.018228034,
0.0052377908,
0.04007822,
0.034032613,
-0.015478845,
0.01730295,
-0.035153136,
-0.0120912185,
-0.018228034,
-0.009042355,
0.020143345,
-0.0100716725,
-0.008644961,
-0.007244308,
0.01157656,
-0.0029560293,
0.023426736,
0.004074923,
0.0007654732,
0.02393488,
-0.018384386,
0.01949188,
0.009882747,
0.023387648,
-0.013250829,
-0.012221512,
-0.017107511,
-0.013772002,
0.006315968,
-0.018814353,
-0.034918606,
-0.020703606,
0.0018224776,
-0.00048208522,
0.0020684062,
-0.013719885,
0.01090555,
0.02921176,
0.017146599,
-0.010351803,
-0.018827382,
0.0330945,
0.0026970715,
-0.0039706887,
0.028169412,
0.008345286,
-0.0006661245,
0.009016297,
-0.0031840426,
-0.0057557067,
-0.005416944,
-0.031114042,
-0.01100327,
0.0070879557,
-0.0028338793,
0.00094869814,
-0.016690573,
0.0040521217,
-0.012540731,
0.010729654,
0.019009793,
-0.011061901,
-0.00013711334,
-0.0021677548,
0.022410449,
0.03757659,
-0.013087963,
-0.022944652,
0.0009633561,
-0.028794821,
-0.030436516,
-0.002732902,
-0.007433233,
0.06472971,
-0.0159479,
0.023908822,
-0.0001888235,
0.009583073,
-0.02297071,
-0.017824125,
0.01967429,
0.0017785036,
0.023426736,
0.015934872,
-0.0026905567,
0.0058110813,
-0.013693826,
0.011061901,
-0.022475595,
-0.03484043,
-0.002288276,
0.0047817645,
0.03153098,
-0.0012915324,
-0.0196352,
-0.016208487,
0.027101008,
-0.021980481,
-0.01732901,
0.017837154,
-0.014097735,
0.0041074962,
-0.0112508265,
0.020755723,
-0.011960926,
-0.0025179181,
0.017537478,
-0.008944635,
-0.004671015,
-0.0019886016,
0.000336116,
-0.0012597734,
-0.013928355,
0.0127492,
0.0071140146,
0.015986988,
-0.00345603,
-0.027361594,
-0.0066677597,
-0.03603913,
0.027934885,
0.019530967,
0.00074470765,
-0.001684041,
-0.014840407,
0.0056091268,
-0.03095769,
-0.0039544017,
-0.0017475589,
0.016755719,
0.014175911,
0.007511409,
-0.024052145,
0.017954417,
0.0028892541,
-0.031583097,
0.003153098,
-0.007439748,
0.008384374,
-0.014684056,
0.013159624,
0.023830645,
-0.0047459337,
-0.018319238,
-0.0067035905,
0.007589585,
-0.00000807335,
0.0147882905,
-0.012983728,
0.027726416,
0.005745935,
0.0043745977,
0.005169387,
-0.0025439768,
-0.014501645,
-0.032364856,
-0.03874923,
0.020429991,
0.18084711,
-0.024456054,
0.008501638,
0.00060504954,
0.007980465,
-0.00052605924,
0.017485362,
-0.011752456,
0.0026775275,
-0.008651475,
0.0060130362,
-0.008241052,
0.008501638,
0.0066547305,
0.000757737,
-0.02450817,
-0.03129645,
0.020299697,
-0.018775266,
-0.0029055406,
0.017029336,
-0.006749193,
0.02780459,
0.00071539165,
0.043544024,
0.012631936,
-0.034892548,
0.017772008,
0.0058208536,
0.0025097749,
-0.032495152,
0.0046547283,
0.0007996752,
0.01517917,
0.004475575,
0.008371345,
0.0028680814,
-0.016482104,
0.015713373,
0.0018094482,
0.0014649853,
0.013159624,
-0.03035834,
-0.011472326,
0.016299693,
0.0035114046,
-0.018762236,
-0.026996773,
-0.012488613,
-0.004306194,
-0.03371991,
-0.0084886085,
0.013133565,
0.005970691,
0.016912071,
-0.0008574928,
0.03194792,
0.00041123826,
-0.005905544,
0.013641709,
-0.006710105,
0.008358316,
-0.04205868,
0.047921877,
-0.013309461,
0.03322479,
-0.032729678,
-0.028638469,
0.007850172,
-0.022749212,
-0.0006494307,
-0.0073941452,
-0.016195457,
-0.00032451176,
-0.020899046,
0.00066368154,
0.003534206,
0.0040130336,
-0.008872974,
0.009967438,
-0.00008102615,
0.00942672,
-0.024169408,
0.015517932,
0.0068794866,
-0.03465802,
0.01751142,
0.007524438,
-0.042345323,
0.0019446276,
-0.007100985,
0.0063224826,
-0.016403927,
-0.014762231,
0.028899055,
-0.016377868,
-0.012293173,
-0.007837142,
-0.008879488,
-0.0318958,
-0.015465816,
0.08985026,
-0.0017247576,
-0.0040032617,
-0.012781774,
0.015270376,
-0.010788286,
-0.014110765,
0.0055374657,
0.0075439825,
0.0058110813,
-0.040338807,
0.0095505,
-0.010736168,
-0.020273639,
0.017863212,
0.0013273631,
0.0019658003,
-0.00081026147,
0.0026628694,
0.006140072,
-0.023661265,
0.0049902336,
0.026410453,
-0.012612392,
0.00730294,
-0.044846956,
0.0206124,
0.009557014,
-0.039817635,
0.011224768,
-0.0069772066,
0.0049413736,
0.016104253,
0.02743977,
-0.009302942,
0.032026093,
-0.025993515,
-0.0032524467,
0.02843,
-0.004390884,
-0.006218248,
0.0033355085,
-0.0030814367,
0.022423478,
-0.01031923,
0.012964183,
0.012886008,
-0.012032587,
-0.028716644,
-0.0062996815,
-0.0071856757,
0.0057426775,
-0.020208491,
0.022527713,
-0.025120549,
-0.018201975,
-0.012104248,
0.012644965,
-0.0017215003,
-0.02743977,
0.012690568,
-0.00046091256,
0.00092263945,
-0.029289935,
-0.0024560287,
-0.16114676,
0.011413693,
0.0108469175,
-0.01061239,
0.019387644,
0.015517932,
-0.002553749,
-0.007947892,
-0.000679561,
0.020547254,
0.04336161,
-0.025042374,
-0.035934895,
-0.02882088,
-0.011498384,
0.0036612418,
-0.019140087,
0.05078833,
0.0104104355,
0.013602621,
0.03231274,
-0.018892528,
0.014397411,
-0.025902309,
0.009133561,
0.023817616,
0.008625417,
0.018749207,
0.01235832,
-0.017342038,
-0.015335522,
0.005882743,
0.051127095,
0.0046579856,
0.0128664635,
-0.015061907,
0.012332262,
-0.009159619,
0.0040423498,
0.029837167,
0.044351842,
-0.019387644,
0.01809774,
0.0040000044,
-0.037759,
0.023074944,
-0.0060260654,
-0.004436487,
0.028456058,
-0.004514663,
0.010840403,
0.003534206,
-0.0016921842,
0.0020732922,
0.0151921995,
0.00044136858,
0.0045081484,
0.019322498,
-0.004612383,
0.0037426753,
0.0034299712,
-0.034188963,
0.039009817,
0.001505702,
0.0060651535,
-0.01537461,
0.014970701,
0.009003268,
0.0004914501,
0.013889266,
-0.008188934,
-0.015583079,
0.0034201993,
-0.025902309,
0.029524462,
0.012338776,
-0.012117278,
0.009081444,
0.0064788344,
0.00041571708,
-0.017029336,
-0.010684051,
-0.021329014,
-0.01732901,
-0.02746583,
0.008325743,
-0.009986982,
0.032573327,
-0.01400653,
0.004504891,
0.019348556,
-0.04049516,
-0.033042382,
-0.00984366,
0.0034201993,
0.018501649,
0.0022540742,
0.00971988,
0.0010309458,
0.023583088,
0.017472332,
-0.01848862,
-0.013263859,
0.022071686,
-0.002938114,
-0.020508166,
-0.009752454,
-0.0021677548,
0.031348567,
0.02140719,
0.0018713376,
0.014970701,
0.02122478,
0.018241063,
-0.008977208,
0.013315976,
-0.009804571,
-0.011641707,
0.007342028,
-0.033042382,
0.070410505,
-0.007837142,
0.0033061926,
0.015205229,
-0.031817626,
-0.03228668,
-0.14332263,
-0.023700353,
0.033798084,
-0.016586337,
-0.011524443,
0.01945279,
-0.010625419,
0.004514663,
0.0015928356,
0.006192189,
-0.033772025,
-0.0013754087,
0.0046645002,
-0.017042365,
0.009680793,
0.010892521,
-0.0033908833,
-0.016091224,
-0.010925094,
0.03132251,
0.0019234549,
-0.023791557,
-0.007667761,
0.002859938,
-0.004993491,
0.004192187,
-0.009081444,
0.028846938,
-0.0031351827,
0.01749839,
0.016000018,
-0.0063713426,
0.01196744,
-0.009094473,
0.008729652,
0.01890556,
-0.014814349,
-0.005338768,
0.023583088,
-0.0131726535,
-0.0018811096,
0.0044006566,
0.009061899,
-0.005061895,
-0.0010749198,
-0.0068143397,
-0.021172661,
-0.01929644,
0.020716636,
-0.023843674,
-0.037993528,
-0.043048907,
-0.060768798,
-0.015557021,
0.01002607,
0.0053974004,
0.014097735,
0.024273643,
-0.011335517,
0.02665801,
0.0061465865,
0.004749191,
-0.025772016,
-0.002742674,
0.023465825,
-0.016872983,
-0.007433233,
-0.0070162946,
0.022332273,
-0.03643001,
-0.010657992,
-0.010931608,
-0.014162882,
0.0023045628,
-0.0052052177,
0.02509449,
-0.0027915342,
-0.023009798,
0.006931604,
-0.023713382,
-0.017954417,
-0.011374606,
0.0036938153,
-0.0112834005,
0.058058698,
0.005394143,
0.01041695,
-0.0139804715,
0.012293173,
-0.00034059485,
-0.034215022,
0.03890558,
0.009120531,
-0.0077394224,
0.0030928373,
0.004947888,
-0.006794796,
-0.00984366,
0.023830645,
0.015739432,
-0.022918593,
-0.0052377908,
-0.0482867,
0.016703602,
-0.009791542,
-0.0035276914,
0.0139804715,
-0.006289909,
0.011615648,
-0.018110769,
0.011035843,
0.03150492,
-0.02607169,
0.009446264,
-0.02179807,
0.02607169,
-0.012710112,
-0.012853434,
0.0038990271,
-0.0046482137,
0.016273635,
0.011986984,
-0.021498395,
-0.010749198,
0.004182415,
0.014631938,
-0.022827387,
-0.0048436536,
-0.023504913,
0.009824115,
-0.018058652,
-0.017159628,
0.029185701,
-0.04338767,
-0.020182433,
0.021641718,
-0.022045627,
-0.01867103,
-0.00018434467,
0.042658027,
0.011009784,
0.034423493,
-0.0039609163,
-0.034345314,
0.011511413,
-0.019570054,
-0.010736168,
-0.024416966,
-0.029107524,
0.021732923,
0.013355064,
-0.026579835,
0.036351833,
0.0010032584,
0.0017443016,
-0.03682089,
-0.018931618,
0.009094473,
0.016469074,
-0.005925088,
-0.00008759171,
-0.018123798,
-0.003996747,
0.023270383,
0.019934876,
0.008566785,
-0.012019558,
-0.025537487,
-0.011700339,
-0.01401956,
0.0062931664,
0.0021416962,
-0.0048697125,
0.0040977243,
0.0065570106,
-0.008631932,
0.010631934,
0.014892525,
-0.0053127096,
0.006970692,
-0.010644963,
0.018215004,
0.014775261,
0.0055472376,
-0.036925122,
0.016299693,
0.022488624,
0.0049088,
-0.027074948,
0.026475599,
0.017094482,
-0.027179183,
0.0027443029,
0.0002302527,
0.0046319272,
-0.0007190562,
0.019166145,
0.016065165,
-0.0002740231,
0.006755708,
0.010690566,
0.036325775,
0.00014240651,
0.007491865,
0.0063615707,
-0.017915329,
0.00063151534,
-0.004488604,
-0.045654774,
-0.036247596,
-0.030723162,
0.011882749,
0.0053974004,
0.01381109,
-0.007667761,
0.0009714995,
-0.035101015,
0.012397408,
-0.023335531,
0.014110765,
-0.013185683,
0.023856705,
-0.0015187314,
0.008410433,
-0.0028322507,
-0.019231291,
0.0005985349,
0.0007813527,
0.0053485404,
-0.017068423,
0.01557005,
0.041172683,
0.00700978,
0.000072170275,
-0.040338807,
-0.016078195,
-0.0034886033,
-0.024364848,
0.020104257,
0.022254096,
0.008312713,
0.07327695,
0.011863206,
-0.018188946,
0.017589597,
-0.0198567,
0.00072923535,
-0.01051467,
0.022097744,
0.010293171,
-0.015296434,
0.006775252,
-0.010671021,
0.021485366,
-0.02432576,
-0.022527713,
0.009368089,
-0.022527713,
-0.019374615,
0.018723149,
-0.007550497,
0.016508162,
0.006657988,
0.006657988,
0.0039674314,
-0.03231274,
-0.0012426724,
0.022410449,
-0.0085863285,
-0.00914659,
-0.045628715,
-0.0020765495,
0.014840407,
-0.04802611,
-0.02626713,
-0.008371345,
-0.012762229,
-0.0045993538,
-0.014306205,
0.024195466,
0.022631947,
0.011700339,
0.019700348,
-0.035309486,
-0.025029344,
-0.012644965,
-0.016039105,
-0.02315312,
-0.029289935,
-0.011361577
] |
We have previously demonstrated that implanted microvessels form a new microcirculation with minimal host-derived vessel investment. Our objective was to define the vascular phenotypes present during neovascularization in these implants and identify post-angiogenesis events. Morphological, functional and transcriptional assessments identified three distinct vascular phenotypes in the implants: sprouting angiogenesis, neovascular remodeling, and network maturation. A sprouting angiogenic phenotype appeared first, characterized by high proliferation and low mural cell coverage. This was followed by a neovascular remodeling phenotype characterized by a perfused, poorly organized neovascular network, reduced proliferation, and | [
-0.020126184,
-0.014256608,
0.013125773,
-0.005893135,
-0.017864512,
0.016329806,
-0.015804777,
0.01392005,
-0.04876056,
-0.020301195,
0.01288345,
0.00004088657,
-0.0074042818,
-0.011119885,
-0.005344545,
-0.0070340675,
0.041033182,
0.0015355471,
-0.0047185468,
0.0039781188,
-0.025336105,
0.041437052,
-0.0129373,
-0.010157328,
-0.0010298683,
0.013583492,
0.006593176,
-0.032605764,
-0.0066739502,
-0.00473874,
-0.0027210736,
0.007283121,
-0.016531741,
-0.0047690305,
-0.009120729,
-0.0036079045,
0.0018073178,
-0.011873775,
0.011395862,
0.020893537,
0.0058830385,
-0.0012705075,
-0.00554648,
-0.00020067286,
-0.016666366,
-0.013973899,
-0.0121228285,
-0.0021556558,
-0.012459387,
0.026413092,
0.02610346,
-0.011846851,
-0.0012116097,
0.015872087,
-0.0189415,
0.010116941,
-0.0059065977,
0.017851051,
-0.00015986517,
-0.017783739,
0.0020260809,
0.01830877,
-0.015979785,
0.013361363,
-0.020893537,
0.011793002,
-0.005105589,
0.016316345,
-0.000115481555,
-0.018591478,
0.030936435,
0.025511116,
0.0032444217,
-0.008111054,
0.012863257,
-0.010850638,
-0.008225484,
-0.0056474474,
-0.019574229,
0.0137854265,
-0.0046546008,
-0.03575595,
-0.007942775,
0.031044135,
0.01097853,
0.0009920055,
-0.0027446325,
0.012035323,
-0.00037484177,
-0.008427419,
0.030855661,
0.012008399,
0.014539317,
0.016854838,
-0.00047328506,
-0.008521656,
-0.0059974683,
0.009941931,
0.029428655,
-0.008602429,
-0.0126343975,
0.008272602,
-0.007909119,
-0.032875013,
-0.022078222,
-0.00514261,
0.013395019,
0.01236515,
0.06122668,
0.016370194,
0.009773652,
0.044560313,
-0.011597797,
-0.018268382,
0.021741664,
0.003047535,
0.023734089,
-0.002652079,
0.013388287,
-0.0022616715,
0.017918361,
0.019318445,
0.0155759165,
-0.024918774,
0.029778674,
0.039256155,
0.0054387813,
0.017016387,
-0.036429066,
-0.004476225,
-0.0043012146,
0.00018742088,
0.010534273,
-0.007417744,
-0.0047084503,
-0.010345801,
-0.030074846,
-0.006475381,
-0.053741623,
-0.04009082,
-0.012600741,
0.012957493,
-0.029832525,
0.0044896873,
0.004927213,
0.004153129,
0.04927213,
0.00964576,
0.035244383,
-0.006960025,
0.0019049197,
-0.03459819,
0.011793002,
-0.008743783,
-0.009140923,
0.0098948125,
0.009383244,
0.03055949,
-0.030236395,
0.022805188,
0.0027967992,
0.0025342838,
-0.0079697,
-0.0044223755,
0.0053344485,
-0.0027042457,
-0.0022044566,
-0.009484212,
0.008333183,
-0.024972623,
-0.021741664,
0.0015809825,
-0.029213257,
0.019816551,
0.001471601,
0.014997036,
0.0083803,
0.008912063,
-0.026157308,
-0.041437052,
0.0029532989,
0.009955393,
0.01444508,
-0.0029230085,
-0.010985262,
0.0028960838,
0.01414891,
-0.018672252,
-0.0008123675,
-0.00843415,
-0.025336105,
0.016020173,
-0.018160684,
0.012277645,
-0.637576,
-0.019412681,
0.016720215,
-0.02009926,
0.023370605,
0.022859037,
0.008642816,
-0.025955373,
0.0068321326,
0.0096928775,
-0.01755488,
0.018322231,
0.005300793,
-0.015225896,
0.000051325136,
-0.035028983,
-0.0026891006,
-0.02813627,
0.021405106,
-0.0140412105,
-0.015347057,
0.0044291066,
0.01739333,
0.014781639,
0.002466972,
0.0067614554,
0.023532154,
-0.009975587,
-0.01109296,
0.012674784,
-0.02431297,
0.02153973,
-0.017635653,
0.014350845,
0.05724183,
0.015602841,
-0.00652923,
0.019910786,
0.009134191,
0.028270895,
-0.006058049,
0.014054673,
0.009322664,
-0.0009246938,
-0.020368505,
0.0414909,
0.0034800125,
0.0011872093,
-0.00907361,
0.0077946894,
0.0054084915,
0.0059234253,
-0.02258979,
0.004661332,
0.010763133,
-0.02541688,
0.02512071,
0.004812783,
0.0013117358,
0.0189415,
-0.0005422795,
0.008279333,
0.00008829396,
-0.038744587,
0.017527955,
0.03096336,
-0.007962968,
0.0073504327,
0.00021602833,
-0.021028161,
0.016316345,
0.039417703,
0.008514924,
-0.011914163,
0.004620945,
0.027597778,
0.006926369,
0.025161095,
-0.00047412646,
0.023370605,
-0.01513166,
-0.01322674,
-0.01357676,
0.0317711,
0.02697851,
-0.0055195554,
-0.031582627,
0.015804777,
0.000005137115,
0.0068590576,
0.007700453,
0.001822463,
-0.044102594,
-0.062357515,
-0.03599827,
0.05457629,
-0.015818238,
0.024447592,
0.0104602305,
-0.016827913,
-0.019547304,
0.0062835426,
0.010197715,
0.0015338643,
0.006327295,
0.013246933,
-0.019910786,
-0.00412957,
0.01698946,
-0.04754895,
0.010810251,
0.024622602,
0.0067109717,
-0.003547324,
-0.015225896,
-0.026547715,
0.030801812,
-0.0034564533,
-0.014889337,
-0.01830877,
0.0042137094,
-0.010217909,
0.0071081105,
0.009665953,
0.021876287,
-0.019883862,
0.0036819475,
-0.0010795107,
-0.013078654,
-0.013294051,
0.010541005,
-0.0031720616,
0.025147634,
-0.008191828,
0.013812351,
-0.0080302805,
-0.0026251546,
0.0035203993,
-0.013644072,
-0.02524187,
0.010116941,
0.009793845,
-0.014189296,
-0.013738308,
-0.011564142,
0.0051022233,
-0.0028657936,
0.0050921263,
0.00419015,
0.009248621,
-0.0038737855,
-0.009376513,
-0.0089995675,
-0.005129148,
0.00056668,
-0.0004244841,
-0.012089172,
-0.03357505,
0.0044930526,
0.0011619674,
-0.013556567,
0.006233059,
-0.0080302805,
-0.00068657886,
0.004725278,
-0.022562865,
-0.027072746,
-0.017581804,
0.0008334024,
-0.026372705,
-0.0030509008,
-0.023410993,
-0.004217075,
0.0048733638,
-0.012957493,
0.011294895,
-0.0021842632,
-0.014081597,
-0.008918794,
-0.0007892291,
-0.013166159,
-0.033251956,
-0.0089995675,
0.024905311,
0.030317169,
0.029509429,
0.05048374,
0.010695822,
0.022603253,
0.02004541,
0.001363061,
0.028001647,
-0.026843887,
0.034840513,
-0.020018486,
-0.04579885,
0.008582235,
-0.007868732,
-0.0019099681,
0.02824397,
0.034113545,
-0.014795101,
0.00837357,
0.018093372,
0.018362619,
-0.005129148,
-0.011187197,
0.0039646565,
-0.0015044154,
0.0063441233,
0.0031973035,
0.010137135,
-0.016733676,
-0.029374804,
0.02392256,
-0.0018594844,
0.013193084,
-0.016706752,
-0.0024938968,
-0.0050618364,
-0.0063340263,
-0.002234747,
0.011005456,
-0.00193521,
-0.024999548,
0.029078634,
-0.0096188355,
-0.004233903,
-0.0032545184,
-0.027651627,
0.0061657475,
0.027678551,
0.03026332,
-0.0035506897,
0.01750103,
0.026480405,
0.0050450084,
-0.01616826,
0.01548168,
0.028405517,
0.03599827,
0.026251545,
0.012614204,
0.0072696586,
0.01351618,
0.0015658373,
0.022495555,
0.026951585,
-0.015724001,
0.0035271307,
0.024111034,
-0.012116098,
0.0016769016,
-0.018631866,
0.0045065153,
-0.0010307097,
-0.0017770276,
0.0015784582,
0.006121995,
0.021808976,
0.0018493877,
0.0054219537,
0.0048262454,
-0.013294051,
0.011247777,
0.027759325,
0.023989873,
-0.014889337,
-0.0022145533,
-0.010534273,
0.002885987,
-0.0020597365,
0.011759345,
-0.040117744,
0.00009612946,
0.000840975,
0.020893537,
0.0073235077,
0.015239358,
0.004933944,
0.00061043253,
-0.02489185,
0.0027782884,
0.03349428,
0.0074783247,
-0.00441901,
-0.0019739142,
-0.0041800537,
-0.010695822,
0.0033840933,
0.025793824,
-0.01732602,
-0.0025595257,
-0.004048796,
-0.014997036,
0.0058662104,
0.034490492,
-0.019601153,
0.0062296935,
-0.026332319,
0.012196871,
-0.003241056,
-0.010500618,
-0.01865879,
0.037236806,
0.0068388637,
0.009349588,
-0.0057383184,
-0.02934788,
-0.016437506,
-0.030074846,
-0.004661332,
-0.0006747993,
-0.012136291,
-0.005280599,
-0.0088716755,
-0.0073975506,
0.019318445,
0.020139646,
-0.010891025,
-0.00060622557,
-0.014296995,
0.003483378,
0.01085737,
0.03303656,
0.012351688,
0.016774064,
0.031178758,
-0.0132738575,
-0.0041800537,
0.0044930526,
-0.012109366,
0.027422767,
-0.008811096,
0.017716426,
0.018295307,
0.0074581313,
0.014943187,
0.020907,
0.029482504,
-0.002653762,
-0.017204858,
-0.01739333,
-0.013583492,
-0.008178365,
-0.033251956,
0.03957925,
0.031636477,
0.02425912,
-0.00016522907,
0.0050416426,
-0.0058594793,
0.015737465,
-0.017581804,
-0.019156896,
0.015037423,
0.0104602305,
0.009511136,
0.000044988374,
-0.026884275,
0.013677727,
-0.0073235077,
0.013320976,
0.007087917,
0.019560765,
0.024864925,
0.01414891,
0.0049642343,
-0.012176678,
-0.008003356,
0.0042911177,
-0.027288144,
0.00029259533,
-0.022549404,
0.0113824,
-0.019735776,
-0.009524599,
-0.026332319,
0.026399631,
0.026547715,
0.0005460658,
-0.01132182,
-0.0042271717,
-0.00346655,
-0.02258979,
-0.031286456,
0.0079697,
-0.022455167,
-0.016720215,
-0.009665953,
-0.010238103,
-0.0053916634,
-0.01797221,
-0.03222882,
-0.007498518,
0.008750515,
-0.032067273,
0.0149028,
0.01322674,
0.02726122,
0.013240202,
-0.018039523,
0.0027076113,
0.012735365,
-0.00543205,
-0.026776575,
-0.003136723,
-0.02073199,
0.014700865,
0.001322674,
-0.047522027,
-0.025147634,
-0.00070551026,
-0.0036280982,
0.020530054,
-0.0014615043,
0.016329806,
-0.0037156031,
-0.000055532113,
-0.0028186755,
0.01865879,
-0.0049305786,
-0.013253665,
-0.018322231,
0.008151441,
-0.0337366,
0.008575505,
-0.026372705,
-0.030451791,
0.00006615473,
-0.022428242,
-0.0052301153,
-0.031232607,
-0.004459397,
0.025430342,
-0.014997036,
0.0024871656,
0.0123786125,
0.020368505,
0.014687402,
-0.015925936,
-0.008575505,
0.010695822,
0.020247346,
0.008938988,
0.01692215,
0.031097984,
-0.0075994856,
-0.034490492,
0.031986497,
-0.010345801,
0.003813205,
-0.024016798,
0.0065124026,
-0.0017955384,
0.037667602,
0.002539332,
-0.0296979,
0.0035607864,
-0.036455993,
0.007767765,
-0.019224208,
-0.00041375632,
0.0024467786,
-0.017043311,
0.008474537,
0.019479992,
0.013233471,
0.024111034,
-0.03629444,
-0.006024393,
0.030182544,
-0.0014682354,
0.0002244423,
-0.011429518,
0.0061657475,
-0.003749259,
-0.012540161,
-0.03015562,
-0.0515338,
-0.01414891,
-0.034059696,
0.03432894,
0.0123786125,
0.026897736,
0.010581392,
0.014431618,
0.056003295,
0.010776595,
0.017945286,
0.0052469433,
0.01057466,
-0.012042055,
0.008265871,
-0.0060614143,
0.0019385756,
0.008292795,
0.008622623,
0.035244383,
0.008360107,
-0.028486291,
-0.0056171576,
-0.0052772337,
-0.037748374,
-0.036052123,
-0.0054387813,
0.0010416479,
0.009013031,
-0.02553804,
0.022455167,
0.008629354,
0.00652923,
0.0026167405,
0.00013493883,
0.025107246,
0.00014566662,
0.046875834,
-0.009679415,
0.005280599,
0.01017079,
-0.013381557,
-0.009861157,
-0.01929152,
0.013260395,
-0.0025376494,
0.018914575,
0.008218753,
-0.005960447,
-0.01109296,
0.005273868,
-0.02074545,
-0.02264364,
-0.0069331,
-0.022414781,
-0.007895657,
-0.0068489606,
-0.016020173,
-0.024420667,
-0.019951174,
-0.007411013,
-0.022684027,
0.01028522,
-0.024057185,
0.0035271307,
0.015616303,
-0.010103479,
0.01155068,
-0.020812763,
0.026870811,
0.032417294,
-0.010157328,
-0.009039955,
-0.0021219999,
-0.005378201,
0.00036158977,
0.019708851,
0.004314677,
-0.019856937,
-0.02512071,
0.026655415,
0.007579292,
-0.018645328,
-0.035082832,
0.02264364,
0.009322664,
-0.010251565,
-0.00027240184,
-0.016720215,
-0.061495926,
0.008824558,
-0.036994483,
-0.006175844,
0.013677727,
-0.007209078,
-0.014485467,
0.023882175,
0.0018460221,
0.014889337,
0.016383655,
-0.015508605,
0.008763977,
0.009046686,
-0.005708028,
0.015643228,
0.007013874,
0.030397942,
-0.009665953,
0.010736208,
0.022226308,
0.016450968,
-0.010406381,
0.00543205,
-0.000047328507,
0.03917538,
-0.004684891,
0.005886404,
0.020530054,
0.02293981,
0.0047858586,
-0.002532601,
-0.010547736,
-0.027274681,
-0.005724856,
0.009039955,
0.026709264,
0.009167847,
0.0010046264,
0.0032864914,
-0.021283945,
0.007983162,
0.0008014294,
-0.026022686,
0.00042385305,
-0.0397408,
-0.0107900575,
0.009046686,
0.029428655,
0.026413092,
-0.01039965,
-0.005633985,
-0.0036314637,
0.015952861,
-0.0100765545,
0.01911651,
0.0315557,
0.003225911,
-0.028970934,
0.015979785,
-0.001886409,
-0.018928036,
0.014741252,
-0.015158584,
-0.031690326,
0.01616826,
0.0027278047,
0.0054657063,
-0.019264596,
-0.01219014,
-0.006458553,
-0.0207993,
0.015818238,
-0.006202769,
0.0053849323,
0.013368094,
-0.020933924,
0.0026251546,
-0.004950772,
-0.013125773,
-0.014875875,
-0.0019688657,
-0.01848378,
0.013078654,
-0.021526266,
-0.012513236,
-0.0035540552,
0.020153109,
-0.022859037,
-0.016504817,
-0.00907361,
-0.029778674,
-0.01444508,
0.011389132,
-0.004378623,
-0.019789625,
-0.0061590164,
0.023989873,
0.007209078,
0.0145527795,
-0.021526266,
0.008178365,
-0.0034379426,
-0.02870169,
-0.02634578,
0.0060041994,
-0.029078634,
0.04593347,
0.021203171,
0.0067749177,
-0.01946653,
-0.0037122376,
-0.06321911,
-0.03066719,
0.0017854415,
0.0077273776,
-0.007215809,
0.002949933,
0.011564142,
-0.0018763123,
-0.0028102614,
0.002362639,
-0.00543205,
-0.011449712,
0.023034047,
-0.0048430734,
0.017595265,
0.006185941,
-0.035271306,
-0.027597778,
0.01577785,
-0.004620945,
-0.00473874,
0.0035978078,
-0.009490943,
0.018564554,
-0.005856114,
0.013603685,
0.02316867,
0.00057467323,
0.0398485,
-0.03430202,
-0.02327637,
0.0097669205,
0.0067715524,
-0.009214966,
-0.012021861,
0.00009255352,
0.030694114,
0.017460642,
-0.0036180012,
-0.007693722,
0.015683616,
-0.0013117358,
0.019614616,
0.005984006,
-0.008346645,
0.03061334,
0.0005603695,
0.016652903,
0.007882195,
0.0009659222,
-0.01184012,
0.006105167,
0.0065056714,
-0.0044459347,
-0.0010500618,
-0.008790902,
0.01993771,
-0.03066719,
-0.013906588,
0.027867025,
-0.0007315935,
0.018847262,
0.0067648212,
0.021028161,
-0.0016794257,
-0.01616826,
0.002741267,
0.0125805475,
-0.016962536,
0.0019385756,
-0.0044930526,
-0.0030811909,
-0.00528733,
0.0015473266,
-0.0009474115,
0.0040218714,
0.017514491,
-0.013233471,
-0.017366406,
0.013556567,
0.17651808,
-0.006717703,
-0.020610828,
0.015239358,
0.005418588,
-0.017016387,
0.024851462,
0.016087485,
0.0027934336,
0.026305394,
0.020947386,
-0.0037122376,
-0.008003356,
-0.006811939,
0.022684027,
-0.031178758,
0.0034177492,
-0.0108641,
-0.007895657,
-0.001161126,
-0.008016818,
-0.034221243,
0.05648794,
-0.001990742,
0.033413503,
0.0029347881,
-0.014593166,
0.0131998155,
0.0217282,
0.01346233,
-0.0041161077,
-0.009430363,
0.005495996,
-0.012169947,
0.020314656,
-0.005714759,
0.01132182,
0.002337397,
-0.00079890515,
-0.0031653305,
0.003789646,
0.024932235,
0.0018325597,
0.00087757566,
0.011624723,
0.02864784,
-0.02564574,
-0.00023117346,
-0.019103047,
-0.014795101,
-0.018443393,
0.0034631845,
0.00606478,
0.0010551101,
0.0020698332,
-0.007363895,
0.014620091,
0.018564554,
0.0051325136,
0.0227648,
-0.03344043,
0.011523755,
-0.019197283,
-0.0034244803,
-0.011490099,
-0.0024181711,
-0.005452244,
-0.013906588,
0.0023912464,
-0.0021236825,
0.013711384,
-0.013543105,
0.0020176668,
0.018456856,
-0.004038699,
-0.02345138,
0.014754714,
-0.0016802672,
0.016154796,
0.021822438,
0.017016387,
-0.0074042818,
-0.024595678,
-0.0013344535,
-0.0060210275,
-0.03344043,
0.027651627,
0.01085737,
-0.0114093255,
-0.012950762,
0.0011442981,
-0.0060210275,
-0.014579704,
-0.005967178,
0.02889016,
0.012553623,
0.015831701,
0.0198704,
0.00441901,
0.009214966,
-0.028109346,
0.07377357,
0.020880075,
-0.0142431455,
0.010493887,
0.0015666788,
-0.015952861,
0.02009926,
-0.012688247,
0.007141766,
-0.0062296935,
0.0068826163,
0.001926796,
-0.017177934,
0.0016794257,
0.012607473,
0.021633966,
-0.05021449,
0.03478666,
0.0013731577,
-0.025080321,
-0.024689915,
0.0021219999,
0.025093785,
-0.010816983,
-0.0047286437,
-0.0218359,
0.028567065,
-0.0059638126,
-0.0030071482,
-0.004927213,
-0.0056003295,
-0.0071081105,
-0.014754714,
0.014579704,
-0.021122396,
-0.0076802596,
0.027234295,
0.00866301,
0.0057450496,
-0.010944875,
-0.012136291,
0.012351688,
-0.001439628,
0.0054455125,
-0.018726101,
0.02125702,
-0.0027210736,
-0.013233471,
-0.017083697,
-0.024838,
-0.0027294876,
0.0034261632,
-0.010695822,
0.023666777,
-0.034436643,
-0.006808574,
-0.03430202,
0.0077879583,
-0.0007917533,
-0.017702965,
-0.0040185056,
-0.0020294464,
-0.01750103,
-0.001943624,
-0.006371048,
-0.16908687,
0.001031551,
0.031259533,
-0.017622191,
0.021162784,
-0.00514261,
0.02218592,
-0.028836312,
-0.023209058,
0.0022768166,
0.054791685,
0.0153201325,
-0.011214121,
-0.028970934,
0.008393763,
0.021122396,
-0.0046007517,
0.03015562,
0.010850638,
0.013482524,
0.02512071,
-0.017662577,
0.0016634392,
-0.01698946,
-0.0053815665,
-0.009739996,
0.013549835,
0.01855109,
-0.0031400886,
-0.0037963772,
0.001237693,
-0.014377769,
0.021997448,
-0.005788802,
0.007814883,
-0.005768609,
0.010527543,
0.00551619,
0.0026487135,
0.026291931,
0.016733676,
0.0021152687,
-0.0056171576,
-0.0189415,
-0.015239358,
0.0106621655,
-0.006475381,
-0.0067008752,
0.032255743,
0.0014623456,
0.009174578,
-0.010069823,
-0.0027749229,
0.0017349578,
0.011927625,
0.01530667,
0.01219014,
0.03268654,
0.009457287,
-0.020220421,
-0.0039478284,
-0.0065090368,
0.0014505661,
0.006482112,
-0.02975175,
-0.023155209,
0.0002816572,
-0.007835076,
-0.028378593,
0.0034211148,
-0.038448416,
-0.014377769,
0.0067109717,
-0.02269749,
0.04512573,
0.03424817,
-0.0018039523,
0.00456373,
-0.010507349,
0.019978099,
0.0016785844,
0.01635673,
-0.013590222,
-0.006024393,
0.009289008,
0.04251404,
0.013502718,
0.015522067,
0.00453344,
-0.0016373559,
-0.00808413,
-0.05551865,
0.016975999,
-0.008521656,
0.014364307,
0.025739975,
-0.0074581313,
-0.014525855,
0.0048666326,
-0.0025746706,
0.029374804,
0.0006188465,
-0.022024373,
0.022630177,
0.011981474,
-0.014606629,
-0.0040858174,
0.021243557,
0.050645288,
-0.012210334,
-0.029617127,
-0.009834233,
0.0041800537,
0.01392005,
-0.016235571,
0.023532154,
-0.0011257874,
-0.0064282627,
-0.007283121,
-0.03090951,
0.052179992,
0.0057618776,
-0.003782915,
0.01795875,
0.00935632,
-0.020408893,
-0.14668556,
-0.025322644,
-0.005782071,
0.016316345,
-0.010648703,
0.014014286,
-0.0003956663,
0.02350523,
-0.020866612,
0.02310136,
-0.018591478,
-0.017999135,
-0.0052368464,
-0.01235842,
0.027355455,
-0.008447613,
-0.0007580975,
0.0060210275,
-0.0030189275,
0.026157308,
-0.019022273,
0.008070667,
-0.014889337,
-0.0011779539,
0.01126797,
0.031259533,
-0.020839687,
-0.004950772,
0.016504817,
0.0129373,
0.0052435775,
0.0008355059,
0.015508605,
-0.0032427388,
-0.0074581313,
-0.0177972,
0.00042217027,
-0.020126184,
0.0073167766,
-0.02246863,
-0.011934356,
0.006677316,
0.047872048,
-0.0021876288,
-0.018403007,
0.010386188,
-0.036402144,
0.0018376082,
-0.00563062,
-0.029374804,
-0.018793413,
-0.0031501853,
-0.0103323385,
-0.009484212,
0.02097431,
-0.014889337,
-0.00041733225,
0.00064366765,
-0.011106423,
-0.005839286,
-0.021297406,
0.011362207,
-0.01074294,
0.0018325597,
0.008063936,
-0.025955373,
-0.022966735,
-0.036859863,
-0.008588967,
-0.02114932,
-0.009214966,
0.00062473625,
-0.00011989888,
-0.018295307,
-0.029670976,
-0.019385755,
0.0017214955,
-0.02789395,
0.0050483737,
-0.035432853,
-0.012742096,
-0.014027748,
0.047791272,
-0.008932256,
0.014296995,
0.03877151,
0.0023205692,
-0.019533841,
0.018564554,
-0.017945286,
-0.0088514825,
0.014943187,
-0.015750926,
-0.023209058,
-0.0122507205,
0.0069061755,
0.00704753,
-0.012903644,
0.0119949365,
0.014418156,
-0.017299095,
-0.00522675,
-0.02975175,
0.018322231,
-0.0021825803,
-0.007209078,
-0.002726122,
0.008171635,
0.007283121,
-0.007013874,
-0.01432392,
0.013395019,
-0.024932235,
0.0029633956,
-0.021472417,
0.010440038,
-0.014364307,
-0.02703236,
0.03230959,
0.0015246089,
0.02720737,
0.032067273,
-0.01772989,
-0.004933944,
0.0064888434,
0.013697921,
-0.012970955,
-0.0044964184,
-0.024407206,
0.0053916634,
-0.013893125,
-0.0067547243,
0.011288164,
-0.026991973,
0.0045670955,
0.0027244391,
-0.0047084503,
-0.020812763,
0.0093092015,
0.02594191,
0.00883802,
0.022441706,
-0.041329354,
-0.014202759,
0.012903644,
-0.007841808,
0.0013798889,
0.0030929705,
-0.012843063,
-0.0074783247,
-0.013583492,
-0.014391231,
0.04488341,
-0.0033874589,
-0.007868732,
-0.049406752,
-0.02385525,
-0.002581402,
0.022818651,
0.0034934748,
0.008487999,
-0.03715603,
0.048545163,
0.009659222,
-0.007363895,
0.00722254,
-0.0038636888,
-0.027113134,
-0.012445925,
0.016854838,
0.004806052,
-0.027530465,
-0.02431297,
-0.018497242,
0.013038267,
0.008737053,
0.0072561963,
-0.013798889,
-0.00033697896,
-0.0030694113,
-0.011651647,
0.019022273,
0.017070236,
0.00935632,
-0.013004611,
0.01674714,
0.009376513,
-0.018120296,
-0.023155209,
0.028728614,
0.0057955333,
-0.0006769028,
-0.022724414,
0.0198704,
0.019479992,
-0.013361363,
0.01369119,
0.013159428,
-0.011692034,
0.015172047,
0.014377769,
0.01651828,
-0.008191828,
0.015454755,
0.018806877,
-0.036052123,
-0.016370194,
0.015993249,
-0.019722315,
-0.018510705,
-0.028620915,
0.0060849735,
0.006610004,
-0.0034160663,
-0.0078014205,
-0.00883802,
-0.011463175,
0.008420688,
-0.0015692029,
-0.0035944423,
-0.011988205,
0.03066719,
0.013610416,
0.015804777,
0.0006411435,
-0.015441293,
0.0032124487,
0.010466962,
0.02085315,
-0.02674965,
0.0009978953,
0.010379457,
0.018187609,
-0.003789646,
-0.022401318,
-0.014296995,
0.0028758903,
-0.03782915,
-0.000242953,
0.02634578,
0.012614204,
0.08077398,
0.0031754272,
-0.014377769,
0.01143625,
-0.036321368,
0.032659613,
0.0062128655,
0.014296995,
-0.009060148,
-0.023545615,
0.013065192,
-0.012567085,
0.014956649,
-0.0397408,
-0.030236395,
0.024366818,
-0.033359654,
0.005085395,
-0.026197694,
-0.016599054,
0.00918804,
-0.00953133,
0.015562454,
0.018052986,
-0.024622602,
0.0053411797,
0.033009633,
-0.0067850146,
-0.00084265776,
-0.0039310004,
0.00722254,
0.01207571,
-0.060849734,
-0.015279745,
-0.014377769,
0.003789646,
-0.024474517,
-0.01853763,
-0.0005990737,
0.009416901,
0.006121995,
0.010816983,
-0.03020947,
-0.030451791,
0.008272602,
-0.01571054,
-0.036240593,
-0.02778625,
0.0061893063
] |
Mouse microRNAs (miRNAs) miR-290-miR295 are encoded by a cluster of partially homologous pre-miRNA hairpins and are likely to be functionally important in embryonic stem (ES) cells and preimplantation embryos. We present evidence that a spliced, capped, and polyadenylated primary transcript spans this entire Early Embryonic microRNA Cluster (EEmiRC). Partial Drosha processing yields additional large nuclear RNA intermediates. A conserved promoter element containing a TATA-box directs EEmiRC transcription. Sequence analysis shows that the EEmiRC transcription | [
-0.04761269,
-0.02772816,
-0.014978979,
-0.04262844,
-0.025550831,
0.0060729133,
-0.0016198808,
-0.003016782,
0.00031028586,
-0.015424937,
0.009325791,
-0.004475986,
-0.008624062,
-0.029748093,
-0.011916289,
0.009319233,
0.0013559123,
-0.009660261,
0.013601752,
-0.00039267354,
-0.03373549,
0.023425968,
-0.018192507,
-0.018559767,
0.005328555,
-0.00892574,
0.01036199,
-0.031479463,
-0.016684117,
-0.039952688,
-0.007889541,
0.0038398388,
-0.009050346,
-0.019648433,
-0.0234522,
0.0017280914,
-0.00029409525,
-0.016211923,
0.017746547,
0.0019936995,
0.031663094,
0.017694082,
-0.009719284,
0.0060204477,
0.01522819,
-0.0018756514,
0.01718254,
-0.0012108117,
-0.0064073824,
0.03853611,
0.01799576,
0.005879446,
-0.022848845,
-0.01895326,
-0.034286384,
0.03053508,
-0.0047120824,
0.030246519,
-0.00553186,
0.006141775,
-0.0027446158,
-0.0029085714,
-0.012795091,
0.0083355,
0.00026171404,
0.032030355,
0.003997236,
-0.018126925,
0.0049022706,
-0.0019674664,
0.019018844,
0.0039316537,
-0.002928246,
0.0015518392,
0.012670484,
-0.038116384,
-0.018559767,
-0.009752075,
0.018113809,
0.0070828795,
0.01600206,
0.0022363537,
0.00037402357,
0.008453548,
0.0014280528,
-0.0007439483,
0.0004935062,
0.018717164,
0.0018149879,
0.0063188467,
0.037119534,
0.035204533,
0.013850965,
0.010873532,
-0.025144221,
-0.009581562,
0.005997494,
0.0449894,
0.000013859367,
-0.02717727,
-0.027098572,
0.022442235,
-0.017510451,
-0.0049744113,
-0.034181453,
0.0061057042,
0.0137198,
-0.024803195,
0.011299816,
-0.0019297567,
-0.01703826,
0.0015092108,
0.012408155,
-0.031138437,
0.012322899,
0.003915258,
0.034417547,
0.0075288387,
-0.013070536,
-0.012657368,
0.019346753,
0.028515147,
-0.0033545303,
-0.045776386,
0.0063483585,
0.021287987,
-0.0041513545,
0.0061483327,
-0.0070566465,
0.012473738,
0.01913689,
-0.006991064,
0.01017836,
0.014611718,
-0.033132136,
0.009824216,
-0.018677816,
-0.0012927895,
-0.020605933,
-0.03355186,
-0.005554814,
0.039690357,
-0.00988324,
-0.009076579,
-0.0040267482,
0.0063418006,
-0.00011456393,
-0.0005947487,
0.019648433,
0.015779082,
-0.0042694025,
-0.015870897,
0.032397617,
-0.00014592044,
0.0010739088,
0.011116186,
-0.002662638,
0.0019428731,
-0.004731757,
0.0015780721,
-0.0036496504,
-0.0065155933,
0.02854138,
0.02430477,
0.025314735,
0.03035145,
0.005295764,
-0.0052531357,
0.010834183,
-0.0078829825,
-0.0051678787,
0.0030594105,
-0.030561313,
0.0054498822,
-0.0074698147,
0.005623675,
-0.012703275,
0.02135357,
-0.029800558,
-0.016303739,
-0.0022002833,
-0.015569218,
0.01703826,
-0.002278982,
-0.02412114,
-0.02684936,
0.00006886133,
-0.006309009,
-0.009122486,
-0.025603298,
-0.0119228475,
-0.0030102239,
0.02725597,
0.0021478175,
-0.6333668,
-0.044963166,
0.011994988,
-0.029590696,
-0.003311902,
0.010296408,
0.006246706,
-0.00045128763,
0.0063418006,
0.009384816,
-0.0234522,
0.00023281686,
0.023412852,
-0.020251788,
-0.025419667,
-0.02267833,
-0.002688871,
-0.014388738,
0.020199323,
-0.0034824158,
-0.049265362,
-0.00027483047,
0.009896357,
0.023675181,
-0.00936514,
-0.0075026057,
0.020435419,
-0.0024101464,
-0.019189356,
0.021510968,
-0.0063844286,
0.019923877,
-0.018349905,
0.009456956,
0.044910703,
0.001924838,
-0.014965862,
0.025039291,
-0.0013928023,
0.031190902,
-0.0059614237,
0.00715502,
0.023373501,
-0.012703275,
-0.0054302076,
0.02426542,
-0.0045382893,
0.00047014252,
-0.008217452,
-0.014716649,
-0.015647916,
0.012572111,
-0.022625865,
0.0025019615,
-0.016539834,
0.01777278,
0.028751245,
0.0004971952,
0.015975827,
-0.002346204,
0.0018363021,
0.020369837,
-0.018664699,
0.0012042534,
-0.011562144,
-0.00907002,
-0.022324186,
-0.006243427,
0.029118504,
-0.004233332,
0.018822096,
0.023688296,
0.0001294224,
0.0071681365,
0.004262844,
0.043284263,
-0.01058497,
-0.0027528135,
-0.004820293,
0.02717727,
-0.015779082,
-0.007876424,
-0.022179905,
0.027675696,
0.012663926,
-0.0009911113,
-0.015647916,
0.024199838,
0.008256801,
-0.0026659172,
-0.005817143,
-0.005410533,
-0.012106477,
-0.038772207,
-0.025695113,
0.004800618,
-0.013227933,
0.019018844,
0.03281734,
-0.020487884,
-0.005587605,
-0.0034069961,
0.0008747028,
-0.0055744885,
0.012145827,
-0.011319491,
-0.019097542,
0.011516238,
0.017746547,
-0.030272752,
-0.0036562085,
0.0064696856,
-0.0026970687,
-0.008453548,
-0.017156309,
-0.027046107,
0.011594936,
0.012781974,
-0.0066729905,
-0.035571795,
0.006118821,
-0.0095028635,
-0.007109112,
-0.0054761153,
-0.00026724752,
-0.010853857,
0.0014362505,
-0.008748667,
0.0027314993,
-0.014205108,
0.025104873,
-0.01324105,
0.027151037,
-0.025104873,
0.023111174,
0.010788275,
0.012375364,
0.014178875,
0.0010034079,
-0.025944324,
-0.026508331,
-0.0245671,
-0.0009665179,
-0.015661033,
0.0041218423,
-0.023478433,
-0.0017871154,
-0.005423649,
0.019123774,
-0.0019281171,
-0.0067943176,
-0.006151612,
0.001471501,
0.008387965,
0.015792198,
-0.007456698,
-0.041421726,
-0.031794257,
0.0070566465,
-0.018520419,
-0.023360386,
0.03373549,
-0.024540866,
0.0293546,
-0.019189356,
-0.0046268255,
-0.008401082,
0.0095028635,
-0.0077387015,
-0.03470611,
0.005722048,
-0.005945028,
-0.018415486,
-0.0002902013,
-0.018205624,
0.0077911676,
-0.01508391,
0.009129045,
-0.0067287353,
-0.02098631,
-0.0078829825,
-0.017379288,
-0.001353453,
-0.010421014,
0.017405521,
0.02485566,
0.034522478,
-0.005328555,
0.022166789,
0.020881377,
-0.020697748,
0.017903944,
-0.025537714,
0.039585426,
0.0035086486,
-0.03016782,
0.032476313,
0.021222405,
0.0031545046,
0.019779596,
0.028698778,
-0.020527234,
0.005587605,
-0.02459333,
0.005240019,
-0.043913852,
-0.014795348,
-0.018690933,
-0.00079559424,
0.011017812,
0.0010173442,
0.01213271,
-0.014388738,
-0.00674841,
0.012414713,
0.0006029465,
-0.012506529,
-0.013057419,
-0.01995011,
-0.022507817,
-0.0023970301,
0.003787373,
0.009824216,
0.0018592558,
-0.003938212,
0.00003594213,
0.0074173487,
-0.008486339,
0.010414456,
-0.0007914954,
0.0059286323,
0.011109628,
0.010788275,
0.008302709,
0.015792198,
0.007850192,
0.01028985,
-0.0067025027,
0.040556043,
-0.011896614,
-0.018481068,
-0.0018576162,
0.0051416457,
-0.010394782,
-0.006066355,
-0.028698778,
0.025865626,
0.028121654,
-0.0015575776,
0.014205108,
-0.019346753,
-0.0114965625,
-0.015805313,
0.001552659,
-0.0025462296,
-0.0052793683,
-0.0010009486,
0.010939114,
0.048871867,
0.03580789,
0.010329199,
-0.016238157,
-0.00047956995,
-0.029853025,
-0.0060860296,
0.008355174,
0.010670227,
0.0074698147,
-0.013470587,
-0.016657883,
-0.020697748,
0.003757861,
0.005030156,
-0.02699364,
0.006656595,
0.012322899,
0.0068730162,
0.0142575735,
0.012145827,
0.026862476,
-0.027413366,
-0.031689327,
0.03919193,
0.0147691155,
-0.014375622,
0.0035643934,
-0.04016255,
-0.0036857205,
0.0012362248,
0.015385588,
0.017497335,
0.017392404,
0.00342995,
-0.001316563,
-0.014834697,
-0.011942522,
0.020186206,
-0.029957958,
0.016657883,
0.004495661,
0.011352282,
-0.024921242,
-0.015241307,
-0.0044267997,
0.023294803,
-0.0027298597,
0.0071681365,
0.0037447447,
-0.007915773,
0.018704047,
-0.023688296,
-0.015044561,
0.0033053437,
-0.018363021,
-0.01681528,
-0.0014034595,
0.009542213,
0.009004438,
0.02143227,
0.007253393,
-0.0026068932,
-0.02139292,
-0.011293258,
0.016841514,
0.029380834,
0.047586456,
-0.012460621,
0.031190902,
0.01644802,
0.010257059,
-0.019307405,
-0.018467952,
0.012736066,
-0.005174437,
-0.0080534965,
0.007181253,
-0.011994988,
-0.013044303,
0.007574746,
0.0156216845,
-0.00402019,
-0.026836243,
-0.001419855,
-0.009942264,
0.017090727,
0.033761725,
0.021143707,
0.035204533,
0.019845178,
0.0012083524,
0.0036758832,
0.018126925,
0.010939114,
-0.009024113,
0.014808465,
0.010296408,
-0.0147691155,
0.00020422712,
0.009784867,
-0.025419667,
0.038693506,
0.020369837,
0.006056518,
0.014716649,
0.016749699,
0.014611718,
0.0073779994,
0.0011493283,
0.0033020647,
-0.004584197,
0.0036299757,
0.0050727846,
-0.014047711,
-0.00804038,
0.016198808,
-0.008919181,
-0.011444096,
-0.0074042324,
0.008414199,
0.018336788,
-0.0058696084,
-0.0072861845,
-0.00844699,
-0.031925425,
0.009804541,
-0.017654732,
-0.015097027,
0.0019773038,
0.0027528135,
-0.018612234,
-0.0017182541,
-0.0026872314,
-0.01644802,
-0.0049580154,
-0.0009443839,
-0.009889798,
-0.028751245,
-0.017523568,
0.009378257,
0.041657824,
0.0074960473,
-0.008119078,
-0.002142899,
0.025970558,
0.010322641,
-0.02267833,
0.011962197,
-0.019609082,
-0.004144796,
-0.0060499595,
0.0010886648,
-0.0074632564,
-0.03659488,
-0.007843633,
0.005479394,
-0.022232372,
0.0130639775,
-0.010932555,
-0.0040726555,
0.025563948,
0.012158943,
0.024331002,
-0.015647916,
-0.013772266,
-0.014874047,
-0.026009908,
-0.028515147,
-0.021012543,
-0.006331963,
-0.022061858,
-0.0071287868,
0.011339165,
-0.016998911,
-0.0142575735,
-0.0019002447,
-0.005977819,
0.00899788,
0.022455351,
0.017746547,
0.0054564406,
-0.0032873086,
0.02363583,
-0.011371956,
-0.0007611636,
-0.0016805443,
-0.017562918,
0.031951655,
0.012650809,
-0.017248124,
0.02603614,
-0.0055777677,
-0.010532504,
-0.016736582,
0.012696717,
-0.019320522,
0.04860954,
-0.0020478046,
-0.028436448,
-0.0018986051,
-0.00851913,
0.0065319887,
0.01249997,
-0.008991322,
-0.009174952,
-0.011234234,
0.014834697,
-0.008164986,
0.004754711,
-0.0013698485,
-0.026705079,
0.012106477,
0.036227617,
0.020159973,
0.01187694,
0.021589667,
0.008617504,
-0.01644802,
-0.023058707,
-0.011857265,
-0.021078125,
0.008958531,
-0.015464286,
0.03871974,
0.020697748,
0.031322066,
-0.013850965,
0.016474253,
0.020343604,
0.033656795,
0.018572884,
0.009299559,
0.022009391,
0.0060138893,
0.004259565,
0.031400766,
-0.006000773,
0.005003923,
-0.019897645,
-0.0034856948,
0.014034594,
-0.018756514,
-0.012880348,
0.01873028,
-0.022324186,
-0.06311633,
0.00047875018,
-0.008768342,
0.025996791,
-0.026023023,
-0.010342316,
0.0019887807,
-0.008145311,
0.025826277,
-0.011352282,
0.022179905,
0.0038037687,
0.032659944,
-0.019176241,
0.012368806,
-0.02279638,
0.013444355,
-0.009817658,
-0.009424165,
0.022009391,
0.0036562085,
0.02116994,
-0.0002389652,
-0.007109112,
0.0043382635,
0.012139268,
-0.03098104,
0.0013206619,
-0.0070435302,
-0.0035283233,
-0.025091756,
-0.019753363,
-0.010466922,
-0.05034091,
0.002456054,
0.02127487,
0.00080666126,
0.01017836,
-0.015333123,
-0.018638466,
0.007823958,
0.0009853728,
0.037591726,
-0.015739731,
0.020474767,
0.021091241,
-0.006440174,
-0.033420697,
-0.023688296,
0.0028774198,
0.010329199,
0.04414995,
0.042602208,
-0.012322899,
-0.006886133,
0.015739731,
0.0049875276,
-0.0019264776,
-0.0393231,
0.02467203,
-0.015542985,
-0.008348616,
-0.00022687348,
0.009994729,
-0.0086502945,
0.009594678,
-0.010998138,
0.010093103,
-0.006807434,
-0.00715502,
-0.023019359,
0.038929604,
-0.013162351,
0.016251273,
-0.015162609,
0.0020379673,
-0.0020297696,
-0.026639497,
0.00066238036,
-0.0004853084,
-0.0091093695,
0.037303165,
-0.0108997645,
-0.0048891543,
0.022140557,
-0.020855146,
0.0022986566,
-0.009666819,
0.0029511997,
0.040031385,
-0.015542985,
-0.010827624,
0.022953777,
-0.0057056528,
0.015700383,
0.0034332292,
0.000004713722,
-0.013398447,
-0.027308434,
-0.019635316,
0.026967408,
0.00040169107,
0.0049481783,
-0.01677593,
-0.027544532,
0.016028294,
-0.021996276,
-0.024658913,
0.008899507,
-0.043520357,
-0.009765192,
0.027780628,
0.038300015,
0.027072338,
0.0054564406,
0.0054925107,
-0.008663411,
0.015582335,
0.0019904203,
0.023950625,
-0.0065549426,
-0.00969961,
-0.020199323,
0.005039993,
-0.0002592547,
-0.02917097,
0.011883497,
-0.04060851,
-0.012447504,
0.029879259,
-0.009561887,
0.025603298,
0.02271768,
-0.019963227,
0.012198293,
0.006272939,
0.011437539,
-0.00069312204,
0.01261146,
0.0132017005,
-0.028147887,
-0.01154247,
0.0032282847,
0.023924394,
0.0037086743,
-0.025301619,
-0.0196222,
0.0059810984,
-0.022402884,
-0.003179098,
-0.009312674,
-0.0008345337,
-0.015831547,
-0.011096511,
-0.006030285,
0.002278982,
-0.0076403283,
0.0073452084,
0.0045087775,
0.0022183184,
-0.02762323,
0.01069646,
0.013523053,
0.008827366,
-0.008748667,
-0.0021773295,
-0.010906323,
-0.021799529,
-0.04708803,
0.008125637,
-0.015556102,
0.030377682,
0.014664183,
-0.0023986695,
-0.011568703,
-0.004672733,
-0.06301139,
-0.038247548,
0.017287472,
0.03252878,
0.022153674,
-0.00043858108,
0.015923362,
-0.019858295,
-0.009312674,
0.0076534445,
-0.0058368174,
-0.011745775,
0.0003449215,
-0.0035578352,
-0.00045333707,
0.005148204,
-0.031112203,
-0.015884014,
0.022284837,
0.030220285,
-0.014795348,
0.021563433,
-0.021707714,
0.02621977,
-0.014664183,
-0.005479394,
0.0019297567,
0.017339937,
0.0293546,
-0.034942206,
-0.026796894,
0.02522292,
-0.00774526,
-0.04273337,
0.0011280142,
-0.005174437,
0.019595966,
0.0027823255,
-0.015752848,
-0.011562144,
0.0048170136,
-0.018126925,
0.010243942,
0.012368806,
0.0067287353,
0.008374849,
0.024553983,
-0.0011608052,
-0.041106932,
-0.005856492,
-0.017982643,
0.0030249797,
0.00586305,
-0.0016772652,
-0.011535912,
-0.017536685,
-0.00940449,
-0.016566068,
-0.011089953,
0.0040070736,
-0.00822401,
-0.013824731,
0.006918924,
-0.00874211,
-0.010447247,
-0.00041521742,
0.021773295,
-0.005479394,
-0.023465317,
0.010414456,
0.0011894974,
-0.009981614,
0.026023023,
-0.01165396,
-0.008578154,
-0.0013690288,
-0.006236869,
-0.010171802,
-0.00039410812,
0.030797409,
0.18856199,
0.0014510065,
0.009837332,
-0.0013936221,
-0.008466664,
-0.031007271,
0.0196222,
0.014506786,
-0.032135285,
-0.0053121597,
0.009056904,
0.014651068,
-0.009889798,
0.005151483,
0.01622504,
-0.025301619,
-0.01124735,
-0.010545621,
-0.012670484,
-0.0074960473,
-0.009765192,
-0.0139165465,
0.01202122,
-0.014401855,
0.018126925,
0.005328555,
-0.03832625,
0.013273841,
0.011739217,
0.016618533,
-0.030823642,
-0.013004954,
-0.003093841,
-0.0000073651904,
0.022547167,
0.008361733,
-0.006620525,
0.016303739,
-0.0016764454,
-0.0022133999,
-0.010919439,
0.013306632,
0.009155277,
-0.007423907,
0.026508331,
0.014375622,
-0.013693566,
-0.009843891,
-0.012932813,
-0.00549579,
-0.041474193,
0.019963227,
0.012716392,
0.022232372,
-0.016618533,
0.006512314,
0.0018264648,
0.013123002,
-0.010316082,
0.028934874,
0.0067877593,
0.0015518392,
-0.01854665,
-0.0009140521,
-0.031872958,
0.024029324,
-0.0040037944,
-0.009843891,
0.016211923,
-0.013365656,
0.0098111,
-0.019045075,
-0.007600979,
0.0022593073,
-0.012296665,
-0.012001546,
0.036673576,
0.0072337184,
0.00774526,
0.025603298,
0.0068402253,
-0.022179905,
-0.03898207,
-0.019491035,
0.00995538,
-0.03971659,
0.031400766,
-0.0013264003,
-0.02334727,
-0.009889798,
0.014808465,
-0.022835728,
-0.0066008503,
-0.00582698,
0.025563948,
0.00597454,
-0.009096254,
0.019110657,
-0.0049809692,
-0.01154247,
-0.03473234,
0.068205506,
0.019058192,
0.007850192,
-0.009548771,
0.01913689,
-0.0030889225,
-0.005144925,
-0.005076064,
0.0014050989,
0.01047348,
-0.020802679,
0.018481068,
-0.0047120824,
0.00892574,
0.013969013,
0.028777476,
-0.033919122,
0.032135285,
0.0067057814,
-0.00800103,
-0.027780628,
0.016618533,
0.031138437,
-0.021196172,
-0.0008894588,
-0.032371383,
0.014165759,
-0.0075813043,
-0.034601178,
-0.004295635,
-0.0032594362,
0.028200353,
0.003193854,
0.005413812,
-0.027334668,
0.02717727,
-0.0052596936,
-0.0036168592,
0.0061089834,
0.005387579,
-0.005856492,
0.006548384,
0.017969528,
-0.0128934635,
-0.0074435817,
0.026377168,
0.025681997,
-0.019700898,
-0.03116467,
-0.0390083,
-0.023648947,
-0.0023724367,
-0.0149396295,
0.023937508,
-0.00357751,
-0.01718254,
-0.028725011,
-0.018756514,
0.0019609083,
-0.041736525,
0.018822096,
0.0021871668,
-0.009542213,
-0.017156309,
-0.016552951,
-0.16432281,
-0.0018969657,
0.015949596,
-0.02906604,
0.030823642,
0.020815795,
-0.009430722,
-0.004728478,
0.0004930963,
-0.0057909098,
0.016618533,
0.008899507,
-0.0430744,
-0.030640012,
0.026232887,
0.015411821,
0.008597828,
0.013759149,
0.030272752,
0.005682699,
0.022193022,
-0.026468983,
0.018533535,
-0.0020822354,
-0.001747766,
0.009870124,
-0.0025429504,
-0.021550316,
0.0029151295,
-0.01626439,
-0.016644767,
-0.0043349843,
0.033919122,
0.0023625994,
0.025498366,
0.0037349074,
-0.0038660716,
0.008433873,
-0.004741594,
0.025904976,
0.015503636,
0.018572884,
0.0013108245,
-0.0042169364,
-0.0045710807,
0.028593846,
-0.0006136036,
-0.025314735,
0.028200353,
-0.01113586,
0.004912108,
-0.0043317056,
0.023544015,
0.0030856433,
0.021156823,
0.018100692,
0.011942522,
0.040765908,
0.013083653,
-0.016329972,
-0.012224525,
-0.026783777,
0.041080702,
-0.016054526,
0.02633782,
-0.029459532,
0.0024134256,
0.02772816,
-0.021117473,
-0.0053580673,
-0.016159458,
0.0029413623,
-0.00040578996,
-0.017549802,
0.010152128,
0.02094696,
-0.0063745915,
0.03433885,
-0.004551406,
-0.002754453,
-0.027911792,
0.0122638745,
-0.022560282,
-0.010919439,
0.02349155,
-0.013024628,
0.008538805,
0.001969106,
0.014349389,
0.0044858237,
0.023098057,
-0.008873274,
0.012158943,
-0.009896357,
0.020855146,
0.017287472,
-0.009673377,
-0.021143707,
-0.007948564,
-0.008151869,
0.022140557,
-0.01980583,
-0.006358196,
0.020658398,
0.022612749,
0.007220602,
-0.0147691155,
0.006358196,
0.055771116,
-0.02603614,
0.0047251987,
0.00026417337,
0.021458501,
0.029302135,
-0.0042726817,
0.041736525,
0.0025675439,
0.0010706297,
-0.0145986015,
-0.023570249,
0.046642072,
-0.011870381,
-0.011201442,
0.019333638,
0.012454063,
-0.02562953,
-0.12455375,
-0.019517267,
0.020238671,
0.0057876306,
-0.022048742,
0.035624262,
-0.01522819,
0.038116384,
-0.015097027,
0.026416518,
-0.025170455,
-0.017720316,
0.0010550539,
-0.0102701755,
0.00523674,
-0.0032987855,
-0.0074894894,
-0.024462167,
-0.009647144,
0.04635351,
0.0068599,
0.005564651,
-0.004403846,
-0.0063024512,
0.02540655,
0.02072398,
-0.015372472,
-0.003879188,
0.020107508,
0.018638466,
-0.0068730162,
-0.0102177095,
0.033184603,
-0.0040169107,
-0.03879844,
0.00061483326,
0.009437281,
-0.031269602,
0.021917576,
-0.014782231,
0.005210507,
0.008171544,
0.004800618,
0.00009780973,
0.010040637,
0.0009968497,
-0.014231341,
0.016500486,
-0.0037086743,
-0.020750213,
-0.033945356,
-0.027282203,
-0.022875078,
-0.00023507126,
0.026665729,
-0.024645798,
0.023242338,
0.0157135,
-0.019740248,
-0.01976648,
0.006043401,
-0.017103842,
-0.0007857569,
0.010578412,
0.021563433,
-0.02061905,
-0.003249599,
-0.031427,
0.017051376,
-0.031558163,
-0.006164728,
0.028095422,
-0.013050861,
0.0018608954,
-0.021733947,
0.001555938,
-0.013136118,
-0.030377682,
0.0044595907,
-0.013457471,
-0.0053974167,
-0.028961107,
0.014585485,
-0.0073517663,
0.009397931,
0.008237126,
0.016539834,
-0.01644802,
0.00018680685,
-0.027518298,
0.0011812997,
0.029275902,
-0.010532504,
-0.012336015,
-0.023019359,
0.012093361,
0.01213271,
-0.0012919697,
0.008978206,
0.011568703,
-0.008899507,
-0.019228706,
-0.058761667,
0.0074107903,
-0.008473222,
-0.004584197,
0.015044561,
-0.04900303,
0.012913139,
-0.016251273,
-0.014782231,
0.027911792,
-0.022861961,
-0.0021822483,
-0.00800103,
0.005210507,
-0.03297474,
-0.0029413623,
0.03628008,
-0.0063975453,
0.029957958,
0.026009908,
-0.022206139,
0.004348101,
0.0010099661,
0.008027263,
-0.01758915,
-0.0054564406,
-0.012401598,
0.018782746,
-0.013083653,
-0.010027521,
-0.0035348814,
-0.025878742,
-0.031505696,
0.021327337,
0.0012608181,
-0.0046989657,
0.024632681,
0.03816885,
0.029643161,
0.026350934,
-0.0020445257,
-0.04171029,
0.0035053694,
0.007541955,
0.014847814,
0.008191219,
-0.015333123,
-0.016382437,
-0.0038693508,
-0.012873789,
0.04517303,
0.01508391,
0.007017297,
-0.031138437,
-0.02031737,
-0.013601752,
0.0009960299,
0.0083355,
-0.0076468866,
-0.0017461266,
0.020304255,
0.021510968,
-0.006335242,
0.0069845063,
0.0057876306,
0.0053056013,
-0.005623675,
-0.021550316,
0.0145986015,
-0.015884014,
-0.028488915,
0.003333216,
0.0036365339,
0.0009943903,
0.008663411,
-0.0043743337,
-0.016566068,
0.017090727,
-0.013195142,
0.029459532,
0.013877197,
0.003138109,
0.008597828,
0.017510451,
0.016133225,
0.0025986955,
0.004967853,
0.011339165,
-0.03234515,
0.016644767,
0.0067221774,
0.016461136,
0.0018641745,
0.020684632,
-0.003633255,
0.011529353,
-0.014480554,
0.009850449,
0.0067549683,
0.014637951,
0.014113293,
-0.003987399,
0.00043243275,
-0.041946385,
-0.0035152067,
0.025183572,
-0.025826277,
-0.012716392,
0.011181768,
0.005374463,
0.0035643934,
0.0059187952,
0.0014264132,
0.005817143,
-0.026141072,
0.02267833,
-0.008551921,
-0.023609597,
0.005879446,
0.040398646,
0.011765449,
0.022809494,
0.020330487,
-0.003728349,
0.009693052,
0.004853084,
0.037198234,
-0.018822096,
0.033342,
-0.010263617,
0.018218739,
-0.008656853,
-0.021733947,
-0.014624834,
-0.00969961,
0.006066355,
0.008237126,
-0.006538547,
-0.002429821,
0.083997704,
0.02135357,
-0.020369837,
0.013070536,
-0.018113809,
0.03871974,
0.019031959,
0.016211923,
-0.020802679,
-0.017956411,
0.004761269,
-0.01622504,
0.019845178,
-0.026862476,
-0.025209805,
0.008873274,
-0.0107292505,
0.03297474,
-0.015647916,
-0.020264905,
0.0037119535,
-0.018769631,
0.028488915,
0.015398704,
-0.03769666,
0.011634286,
0.045855086,
0.0087355515,
0.009561887,
-0.017903944,
0.022219256,
0.011549029,
-0.03934933,
0.0067221774,
0.0064664064,
0.013969013,
0.005731886,
-0.028305285,
0.04134303,
0.024724497,
0.009548771,
-0.024724497,
-0.004525173,
-0.0026232887,
0.0006435255,
-0.0011780206,
-0.0055121854,
-0.019005727,
-0.020186206
] |
How follicular helper T cells (TFH cells) differentiate to regulate B cell immunity is critical for effective protein vaccination. Here we define three transcription factor T-bet–expressing antigen-specific effector helper T cell subsets with distinguishable function, migratory properties and developmental programming in vivo. Expression of the transcriptional repressor Blimp-1 distinguished T zone 'lymphoid' effector helper T cells (CD62LhiCCR7hi) from CXCR5lo 'emigrant' effector helper T cells and CXCR5hi 'resident' TFH cells expressing the transcriptional repressor Bcl-6 (CD | [
-0.03701516,
-0.00036199478,
-0.0037506393,
-0.019582985,
-0.004314895,
0.005798555,
-0.014989281,
-0.00014064898,
-0.025557455,
-0.016994048,
0.013688174,
-0.021255836,
0.0025424687,
0.005353789,
-0.01311728,
-0.012041876,
0.022556942,
-0.003342384,
-0.021189453,
0.011524089,
-0.02689839,
0.025743326,
-0.009984002,
-0.019476771,
-0.02385805,
0.0023184263,
0.0015442345,
-0.0502121,
-0.0117431525,
-0.006070725,
0.016316941,
0.0088355765,
-0.0015002558,
0.013017706,
-0.016821451,
-0.03977669,
0.0057487674,
-0.026765624,
0.02822605,
0.020937197,
0.035873372,
0.008364257,
-0.013416003,
0.01725958,
0.00890196,
0.0151884295,
0.017047154,
-0.01448477,
-0.008105364,
0.017153366,
0.012599492,
0.0020163835,
-0.00394315,
-0.0018554048,
-0.033669457,
-0.015746048,
0.01694094,
0.016914388,
-0.017113537,
-0.029235072,
-0.023393368,
-0.002127575,
-0.0040194904,
0.0051546395,
0.019782133,
0.014683919,
-0.0135886,
0.018374814,
0.00210766,
-0.0138873225,
0.01909175,
0.016781623,
-0.008928513,
0.009028087,
0.037732095,
-0.004600342,
-0.015029111,
0.026712518,
-0.0040493626,
-0.0051081716,
0.021322219,
-0.0155203445,
-0.015095494,
0.029898902,
0.01593192,
0.008749279,
0.015759323,
0.036324777,
0.012347237,
-0.010322556,
0.009731747,
0.004225278,
0.038714565,
0.033350818,
0.0071029807,
0.0022088941,
0.014046642,
0.021109793,
0.013409365,
-0.020937197,
-0.020021113,
0.008709449,
-0.024150135,
-0.015878813,
-0.042724095,
0.00087874493,
0.003146554,
-0.001389894,
0.016688686,
-0.011212088,
-0.015161877,
0.018082729,
-0.017325962,
-0.06680785,
0.02315439,
0.022716261,
0.0022570218,
-0.009598982,
-0.0230349,
0.0014961067,
0.018016346,
0.021335496,
0.011305024,
-0.02494673,
0.027694987,
0.009997279,
0.000085156935,
-0.012340599,
-0.0018006387,
-0.003873448,
0.027801199,
0.020764602,
0.0069436613,
0.002049575,
-0.009672003,
-0.009592343,
-0.02498656,
0.0011268514,
0.0032693625,
0.010681024,
0.0033705966,
0.035581287,
-0.012094982,
0.0036510648,
0.007952683,
0.018613793,
0.025437964,
0.008417364,
0.013070812,
0.027004603,
-0.025504347,
-0.010700939,
0.021547921,
-0.0026503413,
0.004072597,
0.008968343,
-0.008112002,
0.039298736,
-0.007468087,
-0.010335833,
0.008291236,
-0.0148565145,
0.032766648,
0.012134812,
0.027801199,
0.021216005,
0.0074083423,
-0.00030121286,
0.0067445124,
0.014126302,
0.01760477,
0.008417364,
-0.024336006,
0.013927152,
0.0026171496,
0.016927665,
0.0045439163,
-0.0075875768,
-0.017458728,
-0.020552175,
-0.009970726,
0.01780392,
0.029952008,
-0.0050384696,
-0.013575323,
0.002280256,
0.013940429,
-0.013070812,
-0.028730562,
-0.02822605,
-0.0020595326,
0.01159711,
0.024760857,
-0.020605283,
-0.6317537,
-0.014418387,
0.036882393,
-0.015135324,
0.009764939,
0.016755069,
-0.009844598,
-0.02291541,
-0.026446985,
0.021242559,
-0.010309279,
0.02315439,
-0.002826256,
-0.029208519,
-0.0033540009,
-0.03975014,
-0.007780087,
-0.010249535,
0.01081379,
0.007972598,
0.009771577,
-0.0013118939,
-0.017857026,
0.04763644,
-0.000601181,
-0.0015002558,
0.016967494,
-0.0019516601,
0.00335732,
0.031040689,
-0.01386077,
0.026792178,
0.0048957462,
-0.01214145,
0.050929036,
0.0135421315,
-0.0012065109,
0.022636602,
0.016781623,
0.054487165,
-0.0024146815,
-0.0043547247,
0.022105537,
0.012480004,
-0.008370896,
0.02416341,
-0.005406895,
0.022158645,
0.032341797,
-0.012473365,
-0.0057288525,
0.0127521735,
-0.022065708,
0.0099574495,
0.018149111,
-0.005021874,
0.0058516613,
-0.00784647,
0.0005447555,
-0.019370558,
-0.0072623,
0.016701963,
-0.044609375,
0.008012428,
-0.013084088,
0.009910981,
0.002393107,
0.007063151,
-0.0075610233,
-0.0027034476,
-0.011072684,
0.021494815,
-0.009333449,
-0.002049575,
0.0109266415,
0.037652437,
-0.0015483834,
-0.022357794,
0.003936512,
0.0015600005,
-0.004248512,
-0.0038468947,
-0.007939407,
0.005914725,
0.0045074057,
-0.01694094,
-0.020977028,
0.010674386,
-0.009944173,
0.025278645,
-0.007023321,
0.010256173,
0.00495881,
-0.04907031,
-0.033988096,
0.024176687,
0.008576683,
0.0035979585,
0.00044891503,
-0.039803244,
-0.00091027684,
-0.015334472,
0.029022647,
0.011630301,
0.000456798,
0.017750813,
-0.023406645,
-0.0013401067,
0.039219074,
-0.037785202,
-0.011158981,
0.007235747,
-0.013993536,
-0.0009484471,
0.020684943,
-0.022118814,
0.021959495,
0.018042898,
-0.008105364,
-0.013728004,
0.038156945,
-0.00495881,
0.014471494,
-0.0035913202,
0.019357283,
0.022198474,
0.0016197452,
-0.016409878,
-0.019105026,
0.0045306394,
0.0077203424,
0.009658726,
0.021733792,
-0.024667922,
0.028544689,
0.0005024363,
0.026261114,
0.0013409365,
0.00023088836,
-0.039404947,
-0.01959626,
-0.012473365,
0.014989281,
-0.012280854,
-0.015453962,
-0.011504173,
0.014272344,
-0.0028860008,
0.009764939,
-0.0037307243,
0.011962216,
-0.0081983,
-0.01963609,
-0.005828427,
0.022981793,
-0.015214982,
-0.017392345,
-0.022689708,
0.0024578304,
-0.01589209,
-0.0052210228,
0.015334472,
-0.0027349794,
0.0028445115,
-0.0059711505,
0.005343831,
-0.007348598,
0.014192685,
0.00042215438,
-0.047025714,
-0.007308768,
-0.026566476,
-0.017339239,
0.014325451,
0.0066283424,
0.0054168524,
-0.014723749,
0.0065652784,
-0.007083066,
-0.024216518,
-0.019463494,
-0.015055664,
-0.009273705,
-0.010727492,
0.025982305,
0.0007862236,
0.008390811,
0.0018985537,
-0.0011716599,
0.028013624,
-0.0072490233,
0.021362048,
-0.020206984,
0.031014137,
0.0073021296,
-0.0456715,
0.026606305,
0.026685964,
-0.010302641,
0.017286133,
-0.004188767,
-0.011291748,
0.021494815,
-0.013674897,
0.021308942,
-0.031571753,
-0.009831321,
-0.016994048,
-0.0046202564,
0.000503681,
0.011902471,
-0.0063628103,
-0.014152855,
0.004832682,
0.00620681,
-0.00722247,
-0.0017923409,
0.013210217,
-0.008112002,
-0.014378557,
0.0088355765,
0.015480515,
0.02158775,
0.012021961,
-0.009984002,
0.007819917,
0.012632684,
-0.019476771,
0.013562046,
-0.008716088,
-0.012486641,
-0.003244469,
0.014139579,
-0.012871663,
0.016794898,
-0.010342471,
0.017352516,
-0.0142059615,
0.03165141,
-0.0009808087,
0.013104004,
0.00511481,
-0.000874596,
-0.001202362,
-0.013137195,
-0.012718982,
0.014099749,
0.0142192375,
0.01983524,
0.0120750675,
-0.015268089,
0.005864938,
0.003056937,
-0.022556942,
0.010714216,
0.0049787248,
-0.013754557,
-0.012811919,
0.024455495,
0.027668433,
0.016091239,
0.0015533621,
0.013688174,
-0.03255422,
-0.0055994056,
0.014962727,
-0.018361537,
-0.0117564285,
-0.0151884295,
-0.0032925967,
-0.021401878,
0.015440685,
0.018242048,
-0.02033975,
0.022105537,
0.023977539,
-0.0050650225,
0.018958984,
-0.003103405,
0.008264683,
-0.012918131,
-0.031146903,
0.0130575355,
0.032846306,
-0.005353789,
-0.002193958,
-0.026885115,
-0.013847494,
-0.0024810645,
0.00008479391,
0.013648344,
0.014630812,
0.0005277448,
-0.004537278,
0.00339715,
-0.008828939,
0.015905365,
-0.0027300008,
0.006684768,
-0.001042213,
-0.008868769,
-0.013163748,
-0.0230349,
0.0065885126,
0.019529877,
0.0070498744,
-0.016210727,
-0.01659575,
-0.009844598,
-0.0068971934,
-0.002803022,
-0.0075809383,
0.009074556,
0.0011816174,
0.013940429,
-0.0040028947,
0.009366641,
0.021428432,
0.021269113,
-0.0022702985,
-0.031757627,
-0.029235072,
0.008224853,
-0.0054998314,
0.029314732,
0.0130575355,
-0.002768171,
0.01721975,
0.0027051072,
-0.015214982,
-0.005101533,
-0.016662132,
0.027243583,
-0.01276545,
-0.008125279,
0.012645961,
0.009685279,
-0.0063893637,
-0.016290387,
0.01838809,
-0.015002557,
-0.008477109,
0.01190911,
0.006883917,
-0.011278471,
0.005433448,
0.009446301,
0.030483073,
0.0151486,
-0.0019815324,
0.006930385,
0.03744001,
-0.00065594696,
-0.010402216,
0.003120001,
0.016609026,
0.020525623,
0.01116562,
0.009187407,
-0.030323753,
-0.0112585565,
0.011145705,
-0.0059014484,
-0.0013135535,
0.0032029797,
0.0236589,
0.003025405,
-0.0035946392,
0.004029448,
-0.0069436613,
0.016728515,
0.009426385,
-0.013163748,
-0.0044211075,
0.011012939,
-0.015878813,
-0.016967494,
-0.018773112,
-0.027880859,
0.009937535,
-0.0024777453,
-0.029925454,
0.0030917882,
-0.035395414,
-0.02150809,
-0.03619201,
0.0074813636,
0.0032378307,
0.0036875755,
-0.00843064,
0.0042717457,
-0.014059919,
-0.010096854,
-0.018135834,
0.006492257,
-0.021322219,
-0.04150265,
0.014710472,
0.016077962,
0.016728515,
0.017472005,
0.0018836175,
0.0047961716,
-0.0007086385,
-0.011942301,
-0.023937708,
0.0021308942,
-0.023605794,
-0.00527081,
-0.0039331927,
0.0037274053,
-0.03013788,
-0.0064258743,
0.007853108,
-0.005051746,
-0.0068971934,
0.020286644,
-0.0043049376,
-0.012174642,
0.019622814,
0.037971076,
0.0290492,
0.0052874056,
-0.0058184694,
-0.022649879,
-0.0057720016,
-0.0077601722,
-0.0006148725,
0.0059943846,
-0.011185535,
0.0033390648,
0.016675409,
-0.018773112,
-0.027456008,
0.01780392,
-0.011464343,
0.018600516,
0.011185535,
0.019649368,
0.032766648,
0.0087957475,
0.0037605967,
0.017697707,
-0.010508428,
-0.007295491,
-0.021733792,
0.023645623,
-0.0073685125,
-0.039404947,
0.0015218302,
0.014458217,
-0.018401368,
-0.006621704,
-0.0009194045,
-0.00464681,
0.012984514,
0.007547747,
-0.008185023,
-0.028597794,
-0.009811407,
-0.009366641,
0.016569195,
0.0061005973,
-0.019556431,
-0.00956579,
0.009964088,
0.004650129,
-0.015679663,
0.009107747,
-0.03505022,
0.0011442769,
0.02377839,
0.0075411084,
0.005755406,
0.010415493,
0.009592343,
-0.02506622,
0.0022304687,
-0.018295154,
-0.040307757,
0.0097583,
-0.026327496,
0.022809198,
0.04025465,
0.038210053,
0.0145378765,
0.024840517,
0.016170898,
0.0033705966,
0.013993536,
-0.0036875755,
0.026539922,
-0.023552688,
0.00921396,
-0.0062632356,
-0.018733282,
0.008357619,
-0.019436942,
0.013767834,
0.028783668,
-0.029420944,
-0.0015782558,
0.013170387,
0.0043115756,
-0.03303218,
-0.0022420858,
-0.0028561284,
0.010953194,
-0.036404435,
0.001007362,
0.013163748,
0.01792341,
0.011198811,
0.024999836,
0.0060939593,
0.008450556,
0.011683407,
-0.003501703,
-0.019025367,
-0.022517113,
-0.019397112,
0.00020578729,
-0.020605283,
0.03759933,
-0.008576683,
0.00012664631,
0.0031996605,
-0.0039896183,
0.0017209792,
0.0112718325,
-0.010050386,
-0.021362048,
-0.017445453,
-0.013382812,
-0.02452188,
-0.04033431,
-0.014657366,
-0.022782644,
0.015214982,
-0.0073817894,
-0.025663666,
0.0071295337,
-0.0008729364,
-0.020791154,
0.027243583,
-0.013728004,
0.030190988,
-0.02385805,
0.020206984,
0.033642903,
0.0008136066,
-0.018042898,
-0.03470503,
-0.012559663,
0.0010330854,
0.026566476,
0.026048688,
0.0019881707,
-0.01186928,
0.019742303,
0.025902646,
-0.005290725,
-0.021454984,
0.013701451,
-0.017445453,
-0.0031764265,
-0.006824172,
-0.009452939,
-0.028677454,
0.007985874,
-0.0023433198,
0.025013113,
-0.016091239,
-0.024960008,
-0.029659923,
0.02045924,
0.008072172,
0.000353282,
0.0017160005,
-0.01382094,
0.004072597,
-0.040971585,
-0.021468261,
-0.017817196,
-0.0029888945,
0.034758136,
0.0049654483,
0.029261624,
0.029314732,
0.010329194,
-0.020764602,
-0.0012397025,
0.0059910654,
0.038236607,
-0.005363746,
0.0032826392,
0.0010637875,
0.0038933628,
0.016462984,
-0.020034388,
-0.0075610233,
0.0042219586,
-0.005556257,
-0.013250046,
0.049362395,
0.010130045,
-0.017644601,
0.0072291084,
-0.019397112,
-0.0062134485,
-0.012002046,
-0.020791154,
0.0072091934,
-0.04548563,
0.019344006,
0.026075242,
0.016927665,
0.020724772,
0.01190911,
0.00573881,
-0.0023317027,
0.0419275,
-0.03783831,
0.010833705,
0.009705194,
0.019662643,
-0.0323949,
-0.009579066,
-0.0093068965,
-0.029341284,
-0.011510812,
-0.02565039,
-0.026553199,
-0.0029142136,
0.0005211065,
0.026712518,
0.0062831505,
-0.032262135,
0.00644247,
-0.008935152,
0.02452188,
0.006684768,
-0.0073817894,
0.020990303,
-0.0035182987,
-0.014829962,
0.01054162,
-0.0039763413,
-0.0016919366,
0.0026885113,
0.0042385543,
0.03146554,
-0.016064685,
-0.015958473,
-0.0010986386,
-0.000095944175,
-0.024256347,
-0.0064258743,
-0.0031648094,
0.006382725,
-0.012207833,
0.005559576,
0.0032511072,
-0.013296514,
-0.022636602,
0.019118303,
0.0052177035,
0.017339239,
-0.017830472,
-0.0017325962,
0.002721703,
-0.027150646,
-0.022198474,
0.0051081716,
-0.028491583,
0.047344353,
-0.001167511,
-0.0133894505,
-0.01659575,
0.006661534,
-0.0448218,
-0.014829962,
0.010216343,
0.0026602985,
-0.0084903855,
-0.0014073196,
-0.010953194,
0.01159711,
-0.0061669806,
0.036882393,
0.006352853,
-0.046866395,
0.023061452,
0.00009231386,
-0.00073145767,
-0.010594727,
-0.03178418,
-0.024614815,
0.035262648,
-0.022424176,
0.011849365,
0.030562732,
-0.039537713,
0.028544689,
-0.024694474,
0.021733792,
-0.004258469,
0.008609875,
0.014272344,
-0.021906389,
-0.010163236,
0.010435407,
-0.0007430747,
-0.0045837457,
-0.010222982,
-0.00659847,
0.0022702985,
-0.0019748942,
-0.025982305,
-0.028411923,
0.011822811,
-0.026951497,
0.021468261,
0.017325962,
0.0003395905,
-0.0004904044,
0.024216518,
-0.0029092347,
-0.011650216,
-0.0056292783,
-0.0091276625,
0.0069502997,
-0.016077962,
0.007680513,
-0.009067917,
0.006983491,
0.010176513,
-0.014962727,
-0.0016770004,
-0.017286133,
-0.01975558,
-0.040467076,
-0.000067886984,
-0.0007136172,
-0.022437453,
-0.0064524272,
0.000105538595,
-0.018149111,
-0.025305199,
0.016462984,
-0.010276088,
-0.0040028947,
0.011550642,
-0.014166132,
-0.0053969375,
0.004656767,
-0.006774385,
-0.003103405,
0.006409278,
0.009764939,
0.18534133,
-0.030005114,
-0.010010556,
-0.013482386,
0.0005165427,
0.0022819156,
0.002842852,
-0.0023283835,
-0.0026951497,
-0.02026009,
0.017365793,
0.010296003,
-0.00827796,
0.005758725,
0.009107747,
-0.037546225,
-0.021932943,
0.00320132,
-0.022278134,
-0.014723749,
0.023234049,
0.0049787248,
0.02353941,
-0.013011067,
0.035076775,
-0.0005953725,
-0.022118814,
0.011836088,
0.014418387,
-0.010979747,
-0.041529205,
0.0091276625,
0.0062167677,
0.0040593203,
0.004095831,
0.01319694,
-0.018149111,
-0.010030471,
0.009373279,
0.00948613,
-0.009519322,
0.022158645,
-0.015427409,
0.008848853,
0.023804942,
0.01124528,
0.0037771924,
0.016117793,
-0.014338727,
-0.009718471,
-0.03510333,
-0.0029009369,
-0.0009716811,
0.014989281,
0.017418899,
-0.007999151,
0.029898902,
0.010050386,
-0.021999326,
0.035899926,
-0.020698218,
0.006429193,
-0.043441035,
0.04450316,
-0.011132428,
0.025902646,
-0.0022570218,
0.0034851073,
0.017485281,
-0.013900599,
0.00043563842,
0.009061279,
-0.012234386,
0.0078863,
-0.00987779,
-0.019450217,
0.021255836,
0.00008183779,
0.011782982,
0.039643925,
0.010329194,
0.013349621,
-0.021468261,
-0.000058966772,
0.010037109,
-0.017657878,
0.037254136,
0.009273705,
-0.023751836,
-0.013621791,
0.004982044,
-0.023021623,
-0.010568173,
-0.0017508515,
0.021733792,
0.005513108,
-0.003290937,
-0.0011932343,
-0.0019748942,
-0.011046131,
-0.023459751,
0.053318825,
0.0034718306,
0.009147577,
-0.011324939,
0.009672003,
-0.0014023408,
-0.0034452775,
0.010886812,
-0.007003406,
0.0083111515,
-0.0242829,
0.01116562,
-0.0017674473,
0.010481875,
0.011145705,
-0.00093600026,
-0.004809448,
0.02498656,
-0.010003918,
0.010262812,
-0.040891927,
0.027668433,
0.038077287,
-0.015029111,
0.007567662,
-0.03412086,
0.014909621,
-0.011690046,
-0.021308942,
0.0047729374,
-0.016237281,
0.0074946405,
0.0071494486,
0.010588088,
-0.029898902,
-0.0017624686,
-0.018720005,
-0.031093795,
0.012387067,
-0.00886213,
-0.019078473,
0.010687662,
0.0019948091,
0.0002638724,
-0.024840517,
0.024176687,
0.003432001,
-0.005898129,
-0.011610386,
-0.0025242134,
-0.026048688,
-0.021388602,
-0.022424176,
0.02963337,
-0.018056175,
-0.0056126826,
-0.026885115,
0.017830472,
0.005131406,
-0.012168003,
0.025836263,
-0.011849365,
-0.016887834,
-0.001584894,
-0.013701451,
-0.16632923,
0.006781023,
0.019304175,
-0.014737025,
0.03146554,
0.021216005,
-0.004806129,
-0.0026188092,
-0.024508603,
0.015201706,
0.047291245,
0.0046136184,
-0.04158231,
-0.027748093,
-0.0032892774,
-0.007448172,
-0.035899926,
0.038873885,
0.027070986,
0.017578218,
0.029341284,
-0.014630812,
0.0120883435,
0.0022736175,
0.0034452775,
0.015746048,
0.016091239,
-0.00894179,
-0.014790132,
-0.015600004,
-0.021136345,
-0.00062524487,
0.028066732,
-0.0052409377,
0.012187919,
0.018998813,
0.005798555,
-0.025544178,
0.015706217,
0.026924944,
0.042458564,
0.003166469,
-0.011112514,
0.019914899,
-0.016316941,
0.04033431,
-0.027987072,
-0.0035813628,
0.0068175336,
-0.017511835,
0.024482049,
-0.009413109,
0.006336257,
0.020512346,
0.013940429,
-0.017896855,
0.0027283411,
0.016701963,
0.010913365,
-0.0041024694,
-0.00421532,
-0.016064685,
0.023340262,
-0.0045439163,
-0.012606131,
-0.009114386,
-0.003853533,
0.014962727,
-0.026593028,
-0.016370047,
-0.013648344,
-0.010714216,
0.021640858,
-0.012300769,
0.0067876615,
0.022769367,
-0.012944684,
-0.004298299,
0.012785365,
0.009618896,
-0.0019898303,
0.0064988956,
-0.023565965,
-0.015307919,
-0.016715238,
0.015600004,
-0.010428769,
0.024893625,
-0.011822811,
-0.003271022,
-0.0011658514,
-0.013767834,
-0.020830985,
-0.0033274477,
0.0007530321,
0.03369601,
-0.0040925117,
-0.01725958,
0.00057213847,
0.014245791,
0.023393368,
-0.028040178,
-0.016781623,
0.002248724,
0.017910132,
-0.0041323416,
-0.029181965,
0.005360427,
0.0473178,
-0.021308942,
-0.0047762566,
0.00952596,
-0.0011160641,
-0.004988682,
-0.008118641,
0.0135421315,
0.010415493,
-0.0011708301,
0.025862815,
-0.023353538,
0.08364258,
0.0064524272,
-0.0076141297,
0.0242829,
-0.029898902,
-0.0051446822,
-0.14678608,
-0.015759323,
0.0035614478,
-0.0041024694,
-0.020724772,
-0.0016512771,
-0.002600554,
0.025942475,
-0.022716261,
0.008669619,
-0.024933454,
0.0071029807,
-0.0062433206,
-0.016569195,
0.008377534,
0.013050897,
-0.0019068515,
-0.0077734487,
0.002049575,
0.022742815,
-0.0017359153,
0.0044410224,
-0.018666899,
-0.0061902143,
0.009067917,
0.015374302,
-0.03297907,
0.024721028,
0.0036510648,
0.016449707,
-0.016170898,
-0.0114245135,
0.028863328,
-0.0077933636,
-0.016648855,
0.018162388,
-0.0094595775,
-0.038634904,
0.029155413,
-0.016330218,
-0.020472515,
-0.0034618734,
0.0019317452,
0.004344767,
-0.013767834,
-0.017392345,
-0.022092262,
-0.006230044,
0.035421968,
-0.0027100858,
-0.039325286,
-0.06314351,
-0.042060267,
-0.032501116,
0.015600004,
-0.018255325,
0.010063662,
0.022092262,
-0.005025193,
0.011470982,
0.018162388,
0.007016683,
-0.019689197,
0.0084903855,
0.037997626,
-0.00238149,
-0.0040427246,
-0.038581796,
0.014272344,
-0.020698218,
-0.02245073,
0.0040394054,
-0.01627711,
0.0042020436,
-0.011470982,
0.006923747,
-0.008331066,
-0.011676769,
0.0045737885,
-0.041051246,
-0.00886213,
-0.010647832,
0.014670642,
0.005164597,
0.036298223,
0.008038981,
0.011484259,
-0.008755918,
0.005446725,
-0.008450556,
-0.008370896,
0.0323949,
-0.00024354261,
-0.021335496,
-0.018109282,
0.0019317452,
-0.0072556618,
-0.00589481,
0.028013624,
0.029128859,
-0.0047032353,
-0.019622814,
-0.06409942,
0.019237792,
-0.015838983,
0.011371408,
0.020233538,
-0.023101283,
0.0073884274,
-0.008357619,
-0.007906215,
0.027456008,
0.011026216,
0.0019234474,
-0.015719494,
0.0005057555,
-0.022702985,
-0.021972772,
0.02569022,
-0.01959626,
0.021401878,
0.033961542,
-0.00792613,
0.004912342,
0.008450556,
0.004477533,
-0.02385805,
0.001690277,
-0.0020246813,
0.009466215,
-0.012247663,
0.012247663,
0.0074614487,
-0.034492604,
-0.015626557,
-0.004779576,
-0.018135834,
-0.015719494,
0.009061279,
0.021601027,
0.019954728,
0.02830571,
0.006923747,
-0.041316777,
0.0065154913,
-0.003900001,
-0.0004497448,
-0.016569195,
-0.025278645,
0.0065022144,
0.022132091,
-0.017272856,
0.033164944,
0.005665789,
0.018281877,
-0.035395414,
0.0034021286,
0.021109793,
-0.0062101292,
-0.009014811,
-0.009353364,
-0.005891491,
0.0016305323,
0.045777716,
0.01573277,
-0.010276088,
0.00675447,
-0.0036942137,
-0.022902135,
0.0106212795,
0.013847494,
-0.020552175,
-0.026924944,
0.019370558,
0.011305024,
0.00577864,
0.014006812,
0.014909621,
-0.014338727,
0.021401878,
-0.041900948,
0.04001567,
0.012971237,
-0.007600853,
0.00024022347,
0.013409365,
0.024548432,
-0.0021142985,
-0.0026520006,
0.01245345,
-0.012473365,
-0.0027382986,
-0.01448477,
0.013243408,
0.012798642,
0.02104341,
0.020074219,
0.01913158,
0.013608514,
0.029208519,
0.0005136384,
0.038873885,
-0.0035481711,
0.0060109803,
0.027933965,
-0.004600342,
-0.024707751,
0.02569022,
-0.012227748,
-0.026101794,
-0.01842792,
-0.0040692776,
-0.005333874,
0.0050152354,
0.0044244267,
-0.009366641,
-0.04540597,
0.019038644,
-0.011251918,
0.01760477,
-0.024296178,
-0.0007891279,
0.0054168524,
0.013362898,
-0.0035813628,
-0.015122047,
0.008264683,
0.010886812,
0.005914725,
-0.022225028,
0.0074017043,
-0.008258045,
0.0151751535,
-0.00059205334,
-0.045113884,
0.0030502987,
-0.007680513,
-0.0085103,
0.0066382997,
0.027907412,
-0.02440239,
0.08757245,
-0.0013168727,
-0.03255422,
0.00620681,
-0.011796258,
0.007952683,
0.011617024,
0.025477795,
-0.027243583,
-0.015546897,
0.025092773,
-0.0004912342,
0.0045505543,
-0.019556431,
-0.038741115,
0.02092392,
-0.02045924,
-0.014790132,
0.015613281,
0.01909175,
0.0096255345,
-0.027987072,
0.010335833,
0.0051878314,
-0.03584682,
-0.0017591494,
0.021335496,
-0.0020362984,
-0.007952683,
-0.018534133,
0.0094595775,
-0.017458728,
-0.04158231,
0.0065022144,
0.028677454,
-0.025265368,
-0.042936523,
-0.0031133625,
0.0016404898,
0.023964262,
0.007899577,
0.027124092,
-0.02249056,
-0.012579578,
0.021295665,
-0.011623663,
-0.008497024,
0.01214145,
-0.0022055751
] |
Inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) have been implicated in atherogenesis. However, the precise role of TNF-alpha in atherogenesis is still unclear. To examine the effect of TNF-alpha on atherogenesis, we generated compound-deficient mice in apolipoprotein E (apoE) and TNF-alpha (apoE-/-/TNF-alpha-/-) and compared them with apoE-/- mice. Although serum total cholesterol levels were markedly elevated in both apoE-/-/TNF-alpha-/- and apoE-/- mice compared to wild-type mice, | [
-0.02053271,
-0.021028416,
-0.012483992,
-0.04474409,
-0.021158867,
0.0061050244,
-0.038534705,
0.019945689,
-0.022032876,
-0.019436937,
0.019384757,
-0.018823825,
0.025855038,
0.0074943085,
-0.010422894,
0.0008471047,
0.03749111,
0.004630948,
0.0023431943,
0.019110814,
-0.019932643,
0.046831276,
0.015901761,
-0.0112251565,
-0.0016942094,
0.009255373,
-0.0006025124,
-0.061154604,
-0.021954607,
-0.024511412,
0.01367108,
0.0021051245,
-0.028385755,
-0.012151347,
-0.008224824,
-0.0021719798,
-0.010168518,
-0.022645988,
0.02143281,
-0.009216239,
0.022854706,
0.0007598668,
-0.0043733106,
0.0051070875,
0.005674542,
-0.021067552,
0.0061996,
-0.008674874,
-0.005198402,
0.017519332,
0.023885256,
-0.0056810644,
-0.011779566,
-0.024994073,
-0.02498103,
0.01618875,
-0.017832411,
0.019958733,
0.005788685,
-0.016801862,
-0.019867418,
0.003447121,
-0.010181563,
-0.005847387,
-0.021615438,
0.0043602656,
-0.0033019963,
0.02911627,
-0.02315474,
0.011616505,
0.04250036,
0.044900626,
-0.03582136,
-0.014871213,
0.0049831606,
-0.0035938765,
-0.018249849,
0.0040047914,
-0.015640864,
0.005863693,
0.024863625,
-0.020937102,
-0.008126987,
0.028594473,
0.04268299,
-0.0079443585,
-0.0008446588,
0.0018898833,
0.009653243,
0.0044417963,
0.027029082,
0.008413976,
0.01942389,
0.01942389,
-0.0038156402,
-0.0036199663,
-0.00011383734,
0.008596605,
-0.003303627,
-0.020010913,
-0.014610315,
-0.006300698,
0.022411179,
-0.010768585,
-0.019997869,
-0.0069007645,
-0.011955673,
0.019267352,
0.027707418,
-0.020050047,
-0.0028861894,
0.04808359,
0.0016567053,
-0.04119587,
0.027916137,
-0.016580097,
0.016684458,
-0.0026138765,
-0.014414641,
-0.00026905155,
0.008792278,
0.019906554,
0.026872544,
-0.002773677,
0.008413976,
0.006330049,
0.011864358,
-0.0035221295,
-0.0341777,
-0.0021198,
0.018315073,
0.0056386683,
0.02302429,
0.01359281,
-0.028385755,
0.0073247245,
-0.050483856,
-0.008577038,
-0.02736825,
-0.03929131,
-0.016593143,
0.027629148,
0.0063887513,
-0.020245722,
-0.0014805988,
0.023350414,
0.045109347,
0.021693708,
0.014505955,
0.008427021,
-0.0076312805,
-0.006101763,
0.014140697,
-0.01727148,
-0.0037536768,
0.025241928,
-0.0052603655,
0.021184957,
-0.015745223,
-0.0039004323,
-0.005146222,
-0.020989282,
0.031751346,
-0.0047516134,
0.022385089,
0.020754473,
0.010553343,
0.009666288,
0.00484945,
-0.021876337,
-0.011042528,
0.0029024954,
0.009418434,
0.03454296,
-0.01157737,
-0.003926522,
-0.00773564,
0.03096865,
0.0036330111,
-0.030159863,
0.0010232112,
0.02744652,
0.041561127,
-0.0056549744,
-0.0016012643,
-0.0027573707,
0.03707367,
-0.0017904157,
0.011929583,
-0.015719132,
-0.0045461557,
0.023611313,
-0.0024263558,
-0.039839197,
-0.63158303,
-0.02122409,
0.024328783,
0.00064205483,
0.0055603986,
0.036838863,
0.0018833609,
-0.0049831606,
-0.018575972,
0.02045444,
-0.012784026,
0.025189748,
0.019084724,
-0.007559533,
-0.017767185,
-0.038586885,
-0.012033942,
-0.00686163,
0.015510414,
0.0061474205,
0.002238835,
-0.0018621628,
0.0053582024,
0.002127953,
0.0028715138,
0.021276271,
0.014349416,
-0.018132444,
0.010057637,
0.039160863,
-0.014766853,
0.025489781,
0.0017186687,
0.00060047413,
0.044091843,
0.0009930448,
0.011857836,
0.024485322,
0.014910348,
0.03282103,
-0.03459514,
0.00019322793,
0.0061082854,
0.0077747745,
-0.021471944,
0.030003324,
0.009516272,
-0.0042754738,
-0.0062224288,
-0.005286455,
0.008068285,
0.013918933,
-0.035195205,
-0.008570515,
-0.016997535,
0.009124924,
0.025515871,
-0.021628484,
0.004562462,
0.026311612,
-0.0010949583,
0.031542625,
-0.015327785,
-0.00863574,
-0.0094314795,
0.030055504,
-0.011133842,
0.010468551,
0.005080998,
0.0021997003,
0.030212043,
0.03707367,
0.004383094,
-0.0038221627,
0.026676869,
0.027863957,
0.013579765,
0.015823493,
-0.0136319455,
-0.0037895504,
-0.0054593007,
0.013410182,
-0.012242661,
-0.0033949413,
0.016462693,
-0.00015806779,
-0.022645988,
0.023637401,
0.006692046,
-0.006692046,
0.026716003,
0.006440931,
-0.028672742,
-0.047405254,
-0.031307817,
0.035169113,
0.020597935,
0.011538235,
0.0015906654,
-0.0127448905,
-0.021967651,
0.004787487,
0.013827619,
-0.007950881,
0.01701058,
0.0017708484,
-0.035456102,
-0.0045168046,
0.04234382,
-0.006271347,
-0.00895534,
0.0028193342,
-0.008303094,
-0.031203458,
0.006512678,
-0.011857836,
0.0028552078,
0.011394741,
0.004549417,
-0.042265553,
0.025163658,
0.0046374705,
0.009777171,
0.0024736437,
0.0015621296,
0.02384612,
-0.0031112144,
-0.018889049,
-0.014805988,
-0.025215838,
0.011720864,
0.0066692173,
0.017258434,
-0.020819698,
0.027890047,
-0.007089916,
0.01881078,
0.025881128,
-0.0067442255,
-0.041587215,
-0.006313743,
0.0032677534,
0.019645656,
-0.0011169716,
0.008420498,
-0.00511361,
0.01703667,
0.008192212,
-0.0002028078,
0.013110149,
0.007611713,
-0.00165589,
-0.0039721793,
0.005876738,
0.022685122,
-0.0025861561,
0.01536692,
0.0028943424,
-0.004911414,
-0.007970449,
-0.020728383,
0.010807719,
0.0021605655,
0.015106021,
-0.007246455,
-0.0032318798,
0.016580097,
-0.0017447586,
-0.0049831606,
-0.01978915,
-0.009614109,
-0.017310614,
-0.023859166,
-0.0013542261,
0.015301695,
0.0093793,
-0.017336704,
-0.03075993,
-0.0030052243,
-0.003714542,
0.0033721128,
-0.0074225618,
0.009516272,
0.0100250235,
0.04628339,
0.010912078,
0.014375506,
0.023141695,
-0.013097104,
0.035508282,
-0.011988285,
0.0013534109,
-0.015745223,
0.007970449,
0.0115317125,
-0.022489449,
0.028281394,
0.021576304,
0.019189082,
0.025281062,
-0.0069790343,
-0.0457355,
0.01944998,
-0.02076752,
0.0326384,
-0.012620964,
-0.008348751,
-0.008714009,
0.022111146,
0.0075725783,
-0.001414559,
-0.00027068215,
0.0005001913,
-0.00009105968,
-0.010266355,
-0.004167853,
0.017180165,
-0.02464186,
0.024185289,
-0.03743893,
0.0012050248,
-0.009744558,
-0.00808133,
-0.016045256,
-0.01801504,
0.012679665,
0.022241594,
0.030107684,
0.005703893,
-0.020010913,
0.0005690848,
-0.0058832606,
-0.011453443,
0.01147301,
0.019841328,
0.007559533,
-0.008029151,
0.011583893,
0.02752479,
0.0008197919,
0.0074616964,
0.009777171,
0.018249849,
0.008074808,
-0.008922728,
-0.00069301156,
0.0094510475,
0.030264223,
0.008472678,
-0.0068681524,
0.019358667,
0.007833477,
0.013110149,
-0.013025356,
-0.012738368,
-0.013775439,
0.016280064,
-0.014049383,
0.060998064,
0.019580431,
0.04450928,
-0.029324988,
-0.011414308,
-0.01894123,
-0.002429617,
0.009790216,
-0.0026236603,
-0.0074160392,
0.009516272,
0.0036069213,
-0.040543623,
0.014505955,
0.010846854,
-0.044717997,
0.021967651,
0.009764126,
0.03589963,
0.024263559,
0.036186617,
0.008870548,
0.0033982026,
-0.035116933,
0.023389548,
0.015745223,
0.0032155737,
-0.010605523,
-0.021002328,
-0.018771645,
-0.013371047,
0.02040226,
0.009659766,
0.007598668,
0.0068224953,
-0.010605523,
-0.018510746,
0.0127188,
0.022385089,
-0.02649424,
0.013788484,
-0.022189416,
0.020963192,
0.0025241927,
-0.0073508145,
0.015223426,
0.034647316,
0.0136189,
0.029664157,
0.0054723453,
-0.005906089,
-0.025215838,
0.016762726,
-0.014362461,
0.015040797,
-0.007637803,
-0.0020725122,
-0.01072945,
-0.011596937,
-0.0020806654,
0.02649424,
-0.008590083,
0.00044515802,
-0.03965657,
-0.0073247245,
-0.0047940095,
0.0010297337,
0.018484658,
0.014479865,
0.004803793,
0.017388884,
0.011623027,
0.0029611976,
-0.021328451,
0.014349416,
-0.011694774,
0.00035160145,
0.0118382685,
0.012953609,
0.0032106817,
0.016384425,
0.01729757,
-0.0026611644,
-0.03436033,
0.006920332,
-0.026220297,
0.00010109816,
-0.014127652,
0.0323775,
0.0065713804,
0.035430014,
0.0033101493,
-0.014871213,
0.027707418,
-0.009151014,
-0.028072676,
-0.008113942,
-0.00033244173,
-0.008707486,
-0.0060528447,
0.005635407,
-0.010918601,
-0.015797403,
0.017975904,
-0.0018931446,
-0.007129051,
-0.000699534,
0.014975572,
0.0024622292,
0.008016106,
-0.023546087,
-0.029064089,
0.025907218,
0.0024769048,
-0.0016599665,
-0.013540631,
0.0074943085,
-0.018302027,
-0.012803593,
-0.0017023626,
0.019215172,
-0.013162328,
0.0048396667,
-0.006310482,
-0.0057136766,
0.004383094,
-0.027968315,
-0.00169584,
0.006206122,
-0.016423559,
0.01454509,
-0.014414641,
0.005955008,
-0.009561929,
-0.00075945916,
-0.011864358,
0.032925386,
-0.012177437,
-0.016306154,
0.0017414973,
0.015119066,
0.017428018,
0.003515607,
-0.028646652,
-0.0044972375,
0.036969315,
0.002832379,
-0.009000997,
-0.0014659233,
-0.024328783,
0.004161331,
-0.0019860896,
-0.033316735,
-0.021824157,
-0.0072921123,
-0.0118513135,
-0.00678336,
-0.020245722,
0.023506952,
-0.008146555,
-0.020610979,
-0.022541627,
0.0043439595,
0.011407786,
0.007853044,
-0.012810115,
-0.0051657897,
0.006284392,
0.0054723453,
-0.022619897,
-0.015940897,
-0.0020382693,
0.0060071875,
-0.008205257,
0.008061763,
0.0054495167,
0.0075921454,
0.00089439255,
-0.012392677,
-0.022841662,
0.0042689512,
0.014962528,
-0.0007688352,
0.0187586,
0.0045135436,
0.0068551074,
-0.009581496,
0.00029065722,
0.022332909,
-0.010859899,
-0.014179832,
0.0051494837,
-0.0061996,
-0.011251247,
-0.028437933,
0.0023937435,
-0.028437933,
0.010285922,
-0.0014300498,
-0.01865424,
-0.03793464,
0.012268751,
-0.005814775,
-0.012112211,
-0.013775439,
-0.004435274,
-0.023467818,
-0.009998934,
-0.029716335,
-0.026429016,
0.022580763,
-0.041561127,
-0.013788484,
0.021902427,
0.01621484,
-0.0069464217,
-0.0016942094,
-0.016658368,
-0.038012907,
-0.023376504,
-0.025241928,
-0.023350414,
0.00123193,
-0.010775107,
0.038717333,
0.029742425,
0.033890713,
-0.009992411,
0.04443101,
0.00042885187,
-0.0021475207,
0.0070246914,
-0.0124318125,
0.027002992,
-0.012333975,
0.010083726,
0.018432477,
-0.01701058,
0.025607185,
-0.025424557,
0.0017692178,
0.0015857735,
-0.00945757,
-0.012542694,
-0.009594541,
-0.0323775,
-0.021993741,
0.0049962057,
-0.017127985,
0.009183627,
-0.026194207,
-0.0010582694,
0.03407334,
0.0003177662,
0.0073247245,
-0.00026375204,
0.02400266,
-0.008087853,
0.00042640595,
-0.019476071,
-0.017401928,
-0.0033346086,
-0.010416372,
0.008668352,
-0.0035938765,
-0.0025372377,
0.00046268714,
0.009718468,
0.004070016,
0.0077095497,
-0.0040928447,
0.008942295,
-0.040595803,
0.0067703156,
-0.0069986014,
-0.005038602,
-0.022032876,
-0.019984823,
0.007318202,
-0.012986221,
0.0043146084,
0.017688917,
-0.023728715,
0.0015955572,
-0.02472013,
-0.013540631,
0.008707486,
-0.011570848,
0.031099098,
-0.038456436,
0.0062224288,
0.0053842925,
0.0027329116,
-0.023454772,
0.015040797,
-0.011081663,
0.01374935,
0.033734173,
0.01462336,
-0.0072595,
-0.011414308,
-0.018928185,
0.007272545,
-0.010664226,
-0.02916845,
0.033708084,
-0.014688584,
0.024537502,
-0.017441062,
-0.009705423,
-0.024876669,
0.007826954,
-0.02890755,
0.00085851905,
-0.0012906322,
-0.029403258,
-0.013827619,
0.028542293,
-0.006206122,
0.0274987,
-0.010005456,
-0.038560793,
0.0019746753,
-0.025476735,
0.014323326,
0.0124252895,
0.016840996,
0.03070775,
0.00678336,
-0.0036330111,
-0.0026709482,
-0.0033982026,
-0.006238735,
-0.0025682193,
-0.021341495,
0.041795935,
0.0008723793,
0.01616266,
0.018862959,
0.0025470213,
-0.008577038,
-0.01462336,
-0.016149616,
-0.03459514,
-0.041352406,
0.00413198,
0.03099474,
-0.009137969,
-0.02739434,
0.020337036,
-0.028255304,
-0.0039330446,
-0.019123858,
-0.016371379,
0.016710548,
-0.034960397,
0.009098834,
0.0047809645,
0.008446588,
0.0011332778,
0.03282103,
-0.0044678864,
-0.02251554,
0.029324988,
-0.030472942,
0.015040797,
0.00096206315,
0.01152519,
-0.004321131,
-0.00055277866,
-0.044770177,
-0.014740764,
-0.003773244,
-0.012307885,
-0.03428206,
-0.011303427,
0.004304825,
0.022411179,
0.010644658,
-0.0013322128,
0.060371906,
0.0017398667,
0.008270482,
-0.006030016,
0.0015433775,
0.02045444,
-0.014349416,
0.0042754738,
0.011792611,
0.021289315,
-0.02040226,
0.018471612,
0.003714542,
0.009464093,
0.013462361,
0.0007610898,
0.0021931778,
0.028672742,
-0.0031536103,
0.0016713808,
-0.01804113,
-0.002323627,
-0.026168117,
0.011890448,
0.012210049,
-0.035221294,
-0.016384425,
0.014258102,
-0.02384612,
0.009548884,
-0.019697834,
-0.0127188,
0.0050451243,
-0.01960652,
-0.043230876,
-0.012679665,
-0.009666288,
0.023441728,
0.010912078,
-0.015236471,
-0.022189416,
-0.005097304,
-0.030577302,
-0.019489115,
-0.010448984,
0.012294841,
-0.00020168675,
0.015810447,
-0.022802526,
0.024015704,
-0.0145320445,
0.012360065,
-0.0118382685,
-0.03078602,
-0.014740764,
-0.011427353,
0.008224824,
0.019097768,
-0.020493574,
-0.036395337,
0.036473606,
-0.005834342,
-0.02747261,
0.021602394,
-0.012255706,
0.0034438598,
-0.03258622,
0.013866754,
0.0022893841,
0.00556366,
0.017493242,
-0.018902095,
0.006705091,
-0.008466155,
0.0043896167,
-0.012686188,
-0.00075497496,
-0.006131114,
-0.0039721793,
0.005084259,
-0.014336371,
-0.02885537,
0.00066406815,
-0.009764126,
0.016554007,
0.031464357,
-0.024994073,
0.008798801,
0.0065094167,
-0.012340498,
-0.018536836,
-0.016723592,
-0.0019616303,
0.017441062,
-0.014310281,
-0.0014096671,
-0.01724539,
0.0048233606,
0.0024345089,
-0.03271667,
0.009235806,
0.007826954,
0.00045045753,
-0.0071551404,
-0.0013436271,
0.005804991,
0.0077747745,
0.007996539,
0.006939899,
-0.021771977,
-0.023141695,
0.00182792,
-0.016684458,
0.008009583,
-0.012327453,
0.005452778,
-0.02400266,
-0.015719132,
-0.008420498,
-0.047170445,
-0.024341827,
0.03386462,
0.1883687,
-0.014636404,
-0.0042950413,
0.004206988,
-0.00080919295,
0.0050581694,
0.0014292344,
-0.0053027617,
-0.025894174,
0.018549882,
0.027081262,
0.008694442,
-0.017571513,
0.0015107652,
0.005182096,
-0.010220698,
-0.021993741,
0.005945224,
-0.008048718,
0.0070573036,
0.010142428,
-0.006952944,
0.048918463,
0.010051114,
0.033395004,
0.029481528,
-0.030551212,
0.0040439265,
0.01462336,
-0.011029483,
-0.029481528,
0.0022208982,
0.011590415,
0.017780231,
-0.0011862727,
0.014375506,
-0.008016106,
0.0039330446,
0.0077291173,
-0.016919266,
-0.0079443585,
0.00032061976,
-0.014962528,
-0.000109760804,
0.0029660894,
0.0127318455,
-0.009411912,
-0.003158502,
-0.031907883,
0.026950812,
-0.035299562,
-0.0044157067,
0.01125777,
0.028229214,
-0.0015278867,
0.0013110149,
0.016032211,
0.011401263,
0.036864955,
0.02562023,
-0.0026057234,
0.00029554905,
-0.04628339,
0.0030476202,
-0.028411843,
0.021328451,
-0.015327785,
-0.03409943,
-0.0046276865,
-0.01449291,
0.0041548084,
-0.017610647,
-0.009842395,
0.007050781,
0.014479865,
-0.018288983,
0.017414972,
0.027968315,
-0.0026627951,
0.016019166,
0.012288318,
0.008309617,
-0.008831413,
0.03096865,
-0.013012311,
-0.032403592,
0.0100380685,
0.0023383026,
-0.014675539,
-0.010488119,
-0.008270482,
-0.014505955,
-0.011192544,
-0.0059126117,
0.029351078,
-0.010807719,
-0.020023957,
-0.018315073,
-0.002930216,
-0.0065159393,
-0.033186287,
0.06992079,
-0.017388884,
0.018406387,
-0.00019699874,
0.002705191,
-0.007813909,
0.008935773,
-0.0026595339,
-0.0018915139,
-0.0038025952,
-0.032012243,
0.009255373,
-0.016032211,
-0.009040132,
0.027811777,
-0.011792611,
-0.028777102,
0.0106381355,
-0.003828685,
-0.014245057,
-0.043100428,
0.001006905,
0.022685122,
-0.014779898,
0.020793607,
-0.028751012,
-0.0023513476,
-0.004376572,
-0.034908216,
-0.00081612304,
-0.01237311,
-0.011303427,
0.023506952,
0.020845788,
-0.0019143425,
-0.0038580361,
-0.01157737,
0.004999467,
0.03553437,
0.008961863,
0.006049583,
0.006952944,
-0.0013631945,
0.009927187,
-0.012314408,
0.0065420293,
-0.0062322123,
-0.01454509,
0.008270482,
-0.015053842,
-0.0196587,
0.011375173,
-0.015027752,
0.0193978,
-0.020128317,
0.005752811,
-0.033838533,
-0.017819365,
0.010377237,
-0.025894174,
0.026585555,
0.01269271,
-0.025607185,
-0.0028992342,
0.0102794,
-0.16207013,
0.0050222958,
0.0071812305,
-0.020337036,
0.027759597,
0.011557803,
-0.0047809645,
-0.005067953,
0.0068681524,
-0.01057291,
0.033551544,
0.0015238101,
-0.0263377,
0.01112732,
0.022137236,
-0.0047353073,
0.0070833936,
0.020806653,
-0.010709883,
0.024941893,
0.033499364,
-0.029559797,
0.012262228,
-0.03563873,
0.0148320785,
0.039500028,
0.007826954,
-0.01200133,
0.009522794,
-0.002625291,
-0.009946754,
-0.0020953408,
0.017819365,
0.0066300826,
0.023780895,
0.0010713143,
0.00028474623,
-0.010559865,
-0.004337437,
0.018536836,
0.02535933,
0.022672078,
0.02395048,
-0.013984158,
-0.014505955,
0.012920997,
-0.0032220962,
0.0028894506,
0.036708415,
-0.006679001,
0.01359281,
-0.01539301,
0.008329184,
0.020858834,
0.010403327,
0.015223426,
0.006440931,
0.029377168,
-0.0009555407,
-0.009503227,
-0.01942389,
-0.0078008645,
0.030003324,
0.014310281,
0.019984823,
-0.016006121,
-0.012020897,
0.013710215,
-0.01978915,
0.0055277864,
-0.024263559,
0.0016069715,
0.017584557,
-0.003727587,
0.0077747745,
0.0048657567,
-0.015027752,
0.021798067,
0.02222855,
0.0063072206,
-0.01714103,
0.0009726621,
-0.039447848,
-0.01865424,
-0.011740431,
0.020689249,
0.011427353,
0.007579101,
-0.0029188017,
0.0024312476,
0.00025478366,
-0.02914236,
-0.0042983023,
-0.0041254573,
0.015927851,
0.028333575,
-0.0047157397,
-0.0035482193,
-0.010018501,
0.025463691,
0.021471944,
-0.02286775,
-0.014140697,
-0.0018116138,
0.036630146,
0.0026187685,
-0.007344292,
-0.004197204,
0.036943223,
-0.024211379,
0.011825223,
-0.0071551404,
-0.009020565,
0.0082378695,
-0.014714674,
0.019828284,
0.016619233,
-0.010853376,
0.014101562,
-0.037778098,
0.08338315,
0.007950881,
0.018667286,
0.03918695,
0.004676605,
-0.02538542,
-0.12022202,
-0.016606187,
-0.014701629,
0.00019414515,
-0.013866754,
0.017728051,
-0.00932712,
0.038560793,
-0.022215504,
0.012092644,
-0.010716405,
0.013292777,
0.007846521,
-0.0064800656,
0.009255373,
0.0029139097,
0.012634008,
0.00022869381,
-0.024380961,
0.03783028,
0.00932712,
-0.015536504,
0.006241996,
0.005990881,
0.002472013,
-0.006343094,
-0.023467818,
0.0036460562,
0.009294508,
0.019384757,
0.022424223,
0.0067703156,
0.0077160723,
0.004846189,
-0.017232344,
-0.021080596,
0.009268418,
-0.024302693,
0.047013905,
0.0084792,
-0.019032544,
-0.0038156402,
0.030499032,
-0.014884258,
-0.010214175,
0.004197204,
-0.049075004,
0.004601597,
0.009000997,
-0.015484325,
-0.009985889,
-0.019162992,
-0.016501829,
-0.010514208,
0.022737302,
0.020102227,
0.013410182,
0.016723592,
-0.013501496,
0.007220365,
0.00855747,
0.0025828949,
-0.007389949,
0.006763793,
0.008720531,
-0.034516867,
-0.019476071,
-0.023833076,
0.002683993,
-0.00048633106,
0.017636737,
-0.007996539,
-0.011766521,
-0.017715007,
-0.027707418,
-0.010912078,
-0.01716712,
-0.011401263,
0.01716712,
0.0053582024,
-0.014245057,
-0.011186022,
0.008322662,
0.009692378,
0.017349748,
0.01534083,
0.009320598,
0.008831413,
0.0035775702,
-0.011786088,
-0.003447121,
0.036630146,
0.017636737,
-0.015836537,
-0.018328117,
-0.0072268876,
0.015484325,
0.0030818633,
0.04119587,
-0.013279732,
0.0016436604,
-0.025881128,
-0.04268299,
0.024054838,
-0.011068618,
0.0030117468,
-0.006258302,
-0.030107684,
0.012920997,
-0.051136103,
0.009216239,
0.016580097,
-0.031046918,
0.0077291173,
0.0014341263,
0.011120797,
-0.0063724453,
0.030003324,
0.015953941,
-0.0010998502,
0.010820764,
0.022111146,
0.010996871,
0.006082196,
-0.0007847337,
0.0037536768,
-0.0066626947,
-0.018589016,
0.024120064,
-0.0017773708,
-0.0032090512,
0.0044124452,
0.011081663,
-0.033395004,
0.010546821,
0.010820764,
-0.010090249,
-0.0030834938,
-0.009366255,
0.018354207,
0.012699233,
0.038534705,
-0.015758269,
-0.038534705,
0.013103626,
-0.0154190995,
0.009294508,
-0.008864026,
-0.022006785,
0.011218634,
0.0034373375,
-0.028072676,
0.016945357,
0.008198734,
0.008642262,
-0.024211379,
-0.03250795,
0.0065061557,
0.013605855,
-0.012536172,
-0.0114991,
-0.036708415,
0.012333975,
0.029507617,
-0.007455174,
0.014271147,
0.008648785,
-0.026585555,
-0.019893508,
-0.005364725,
0.01891514,
-0.025020164,
-0.021811113,
0.007813909,
-0.010135906,
0.0011349084,
0.0018947752,
-0.0009873377,
-0.031907883,
-0.004383094,
0.007781297,
0.0019273874,
-0.0010354408,
-0.007624758,
-0.0411176,
0.018484658,
0.029481528,
0.0044026617,
-0.017388884,
0.01729757,
0.024093974,
0.009183627,
-0.018236803,
0.011564325,
0.014284192,
0.014701629,
0.013116671,
0.012229616,
-0.0013737936,
0.012040464,
-0.011877403,
0.021758933,
-0.00972499,
-0.014114607,
-0.0076051904,
-0.016501829,
-0.021589348,
0.0076312805,
-0.04646602,
-0.03754329,
-0.019945689,
-0.008681397,
0.014088518,
0.0067898827,
0.0064441925,
0.0012841097,
-0.01462336,
0.0130318785,
-0.014010248,
0.02074143,
-0.007950881,
-0.013214508,
0.015158202,
0.0214589,
0.0028062891,
0.012764458,
0.00092048245,
0.01896732,
0.029898966,
-0.010194608,
0.019162992,
-0.0065322453,
0.008642262,
0.014114607,
-0.03073384,
0.0059680524,
-0.014910348,
-0.0062941755,
0.022841662,
0.016501829,
-0.030551212,
0.07044259,
-0.007983494,
-0.0072529777,
-0.004601597,
-0.0051397,
0.014375506,
0.0040308814,
0.013605855,
0.0007032029,
-0.032899298,
0.008146555,
-0.020089183,
0.0052049244,
-0.045526784,
-0.042943887,
0.018393341,
0.002535607,
-0.01367108,
0.011062095,
-0.015549549,
0.002726389,
0.0055734436,
0.0032155737,
0.0045592007,
-0.050927382,
0.0027149748,
0.050927382,
-0.0071029607,
0.013384092,
-0.021302361,
-0.019580431,
0.007983494,
-0.03253404,
-0.0045102825,
0.013579765,
-0.026976902,
0.0008511813,
-0.027029082,
0.0021475207,
0.008446588,
-0.012529649,
0.01544519,
-0.010859899,
-0.025215838,
0.0043602656,
-0.0060756733,
-0.006992079,
0.017545423,
-0.02911627
] |
The recently identified Fas antigen (Ag) is a cell surface molecule that can mediate apoptosis. The cytoplasmic product of proto-oncogene bcl-2 has been shown to prolong the cellular survival by inhibiting apoptosis. To elucidate the physiologic significance of expression of both molecules, we examined the expression of Fas Ag and bcl-2 on blood leukocyte populations and evaluated their sensitivity to the cytolytic action of anti-Fas antibody. Although Fas Ag was expressed on a fraction of lymphocytes, both neutrophils and monocytes expressed Fas Ag constitutively. In contrast, there | [
-0.038823944,
-0.006981025,
-0.019101704,
-0.026723498,
-0.017617814,
-0.0059085777,
-0.02932705,
0.0045022555,
-0.035802204,
-0.00070695527,
0.016066475,
-0.005355492,
0.00071327866,
0.009206859,
-0.018400228,
-0.01400252,
0.028058998,
0.0029323678,
-0.017617814,
-0.0026895495,
-0.011641786,
0.014703995,
-0.013152656,
-0.012747958,
-0.01664654,
0.02236626,
0.003976149,
-0.04767332,
-0.0061277887,
-0.0132335955,
0.0021179148,
-0.009139409,
-0.029111212,
0.012039739,
-0.009409208,
-0.018386738,
0.011722726,
-0.021502906,
0.024659542,
0.011365243,
0.021165658,
0.01119662,
0.0056387796,
0.021125188,
0.004394336,
-0.020450693,
-0.014677015,
-0.01386762,
-0.020153916,
0.011041486,
0.03213295,
-0.007871359,
-0.023189144,
-0.0023792817,
-0.009375483,
-0.028382756,
-0.008208606,
0.034507174,
-0.0038210151,
-0.024295315,
-0.014946813,
-0.011304539,
-0.015014263,
0.017415466,
-0.011742961,
0.012080208,
0.0032662428,
0.020545123,
-0.0021803055,
0.00059229106,
0.027317055,
0.04311373,
-0.0209768,
0.014946813,
0.032699525,
-0.0036557638,
-0.024281826,
0.0047315834,
-0.006886596,
0.012619805,
0.01951989,
-0.010184877,
-0.0015707306,
0.025563367,
0.022649547,
0.0041076755,
-0.006839381,
0.0062761777,
0.008249076,
-0.0057298364,
0.0119722895,
0.018400228,
0.02505075,
0.028409736,
-0.023391493,
0.025428468,
0.025806185,
0.010076958,
-0.011034741,
-0.028922353,
0.0059018326,
-0.0023270084,
-0.011405713,
-0.01246467,
-0.021637805,
-0.013645037,
0.008424445,
-0.014177889,
0.0053622364,
-0.0044415505,
-0.030190405,
0.037474953,
0.0033572996,
-0.05288042,
0.020396734,
-0.019047743,
0.0019425461,
-0.020464184,
-0.017955061,
0.007075454,
-0.00039731982,
0.03787965,
0.02107123,
-0.02107123,
0.022568608,
0.002834566,
-0.010616554,
-0.017887611,
-0.03510073,
0.001629749,
0.035586365,
0.0367465,
-0.0152840605,
-0.017240096,
-0.008667263,
0.0089775305,
-0.04289789,
-0.013159401,
0.0050047543,
-0.010110683,
0.026035514,
0.024551624,
0.008343506,
-0.0030301695,
-0.008727968,
0.017213117,
0.0338057,
0.02099029,
-0.003905327,
0.015580839,
-0.013381984,
-0.03774475,
0.014987282,
-0.02660209,
0.0046641342,
0.012437691,
0.0025344156,
0.010960546,
-0.020396734,
-0.01792808,
-0.0061952383,
0.009139409,
0.024430215,
0.00837723,
0.009544106,
0.0391477,
-0.0003943689,
0.008188372,
-0.010225346,
0.0028531146,
-0.007878103,
0.021921093,
0.014555606,
0.011291049,
-0.0003796143,
0.020383244,
0.0169703,
0.010663768,
-0.0038176426,
-0.024740484,
-0.0030858153,
0.023270084,
0.015567348,
0.0034213767,
0.00916639,
0.021260088,
0.031944092,
-0.016147414,
0.0014577527,
-0.01386762,
-0.028706515,
0.008660518,
0.014069969,
-0.037474953,
-0.6289533,
-0.020180896,
0.017469425,
0.0028058998,
-0.010441185,
0.019371502,
0.02080143,
-0.007810654,
-0.012592825,
0.008903336,
-0.021772703,
0.024416724,
0.0064346837,
-0.019020764,
-0.009018,
-0.027317055,
-0.021489415,
-0.014677015,
0.03483093,
-0.00702824,
0.0015892793,
-0.004755191,
-0.024875382,
0.020167405,
-0.019034253,
0.022784447,
0.03234879,
-0.03488489,
0.0034062006,
0.034615092,
0.00033851227,
0.023917599,
0.01535151,
-0.012977287,
0.050964855,
0.00528467,
0.0099757835,
0.024349276,
0.022892365,
0.011520377,
-0.010630044,
0.014933323,
0.01531104,
-0.013543863,
-0.01684889,
0.018413719,
0.025792696,
0.018467678,
0.0047383285,
-0.0029660924,
0.015135672,
0.02232579,
-0.015176142,
0.0011306226,
-0.0049878918,
0.020167405,
0.035181668,
-0.02505075,
0.0033117712,
0.00908545,
0.0132335955,
0.006232335,
0.0031026779,
-0.021448946,
-0.028679535,
0.011439438,
-0.0195064,
0.0057500713,
0.0052543175,
-0.0019712122,
0.0038446225,
0.017482914,
-0.0013414023,
0.01961432,
0.011054976,
0.029839667,
-0.00024597996,
0.012107188,
-0.007783674,
0.00829629,
0.01405648,
0.0056590145,
-0.024322296,
0.025428468,
-0.00002537261,
-0.0020437203,
-0.0154594295,
0.02509122,
0.016484661,
0.0039356793,
0.007257568,
-0.005669132,
-0.002217403,
-0.03771777,
0.007291293,
0.021475926,
0.0074059567,
-0.0036456464,
-0.012356752,
-0.03342798,
-0.0074059567,
-0.018386738,
0.021435456,
0.00029719944,
-0.0005193613,
0.02237975,
-0.024713503,
0.012336517,
0.03197107,
-0.024389746,
0.013739467,
-0.00086335384,
-0.0027114705,
-0.022811426,
-0.009456422,
-0.015391979,
0.03064906,
0.026318802,
0.016875869,
-0.042412255,
0.003932307,
0.00663366,
0.0043909634,
-0.010663768,
0.027465444,
-0.0036085492,
-0.004144773,
-0.030109465,
0.010616554,
-0.029461948,
0.0067921663,
-0.019965056,
0.00490358,
-0.015135672,
0.023108205,
0.0004192409,
0.01682191,
0.026170412,
0.0056354073,
-0.017901102,
-0.02932705,
0.012019504,
0.019384991,
-0.0059018326,
-0.022986796,
-0.023917599,
-0.016687011,
0.016687011,
-0.0036186667,
0.017051239,
0.018912844,
0.016120434,
0.002821076,
0.0013835583,
0.010029743,
-0.008228841,
-0.007898338,
-0.012208362,
0.0030740118,
-0.009598066,
-0.012741214,
0.0025057495,
0.007959043,
0.004485393,
-0.0046236645,
0.0012714234,
0.028085979,
0.01953338,
-0.006883223,
-0.043788224,
-0.008073707,
-0.015297551,
-0.018656537,
0.030487182,
0.024565114,
0.006407704,
-0.010340011,
-0.0032831053,
0.009530617,
-0.00978018,
0.024673034,
-0.03903978,
0.008754947,
-0.010070213,
0.023593841,
0.0031566373,
0.011992524,
0.0022595588,
-0.021179149,
0.02652115,
-0.0034045144,
-0.0031650686,
-0.03858112,
0.014825404,
-0.015216611,
0.010117427,
0.004438178,
0.01535151,
0.017482914,
0.033401,
0.0035309822,
-0.0037738006,
0.012984032,
-0.0033488686,
0.009011256,
-0.019965056,
0.017563853,
-0.021206127,
0.015553858,
0.014420707,
0.00839072,
0.020356264,
0.00031490493,
-0.01815741,
0.0013666959,
-0.028166918,
0.011952055,
-0.0095036365,
0.007911828,
-0.012687254,
0.0060434765,
0.005166633,
0.014339767,
-0.016471172,
0.0048664827,
0.006569583,
0.01541896,
0.024983302,
0.0014408902,
-0.017941572,
0.0027822927,
0.0062626875,
0.014515136,
0.024753973,
-0.016498152,
-0.00055814476,
0.0152840605,
-0.008127667,
0.030082485,
-0.021084718,
-0.028355777,
0.007082199,
0.0137597015,
0.023539882,
-0.008835887,
-0.023243103,
0.005132908,
0.021529885,
0.003928934,
-0.009463167,
0.005095811,
0.008330015,
-0.02216391,
0.011817155,
-0.012795174,
-0.014204868,
0.0014004206,
0.013145911,
0.029893626,
0.004721466,
0.03787965,
-0.000015821654,
-0.019074723,
-0.0040132464,
-0.00978018,
0.01401601,
-0.0037299583,
-0.015499899,
0.004289789,
-0.0051565156,
-0.027222624,
0.0014484783,
0.012309536,
-0.022919346,
0.0039154445,
0.017361505,
0.019317541,
0.0074261916,
0.02220438,
-0.0079792775,
-0.013179636,
-0.018993784,
0.021678274,
0.021327537,
-0.009213604,
-0.02101727,
-0.012248832,
-0.0069473004,
0.0053386292,
0.0070687095,
0.008734712,
0.0028109585,
-0.0112370895,
-0.003444984,
-0.007392467,
-0.0049507944,
0.010832393,
-0.022082971,
0.02356686,
-0.008080452,
0.0019391736,
-0.012714234,
-0.012181383,
-0.006222218,
0.04605453,
0.01675446,
0.022568608,
-0.01692983,
0.015985535,
-0.02803202,
-0.012511886,
-0.0072373333,
0.004627037,
-0.010225346,
0.0069135753,
-0.00593893,
0.010299541,
0.024349276,
0.018872375,
-0.006343627,
0.008741457,
-0.01821137,
0.014663525,
-0.008464915,
0.014420707,
0.018238349,
-0.0019391736,
0.016066475,
-0.003925562,
0.021219619,
0.002750254,
-0.0031836173,
0.029704766,
-0.022528138,
-0.023040755,
-0.011459673,
-0.006704482,
-0.010751453,
0.0055679576,
0.026426721,
-0.005513998,
-0.01400252,
-0.015999025,
0.0060637114,
-0.0071361586,
-0.0061750035,
0.022555118,
0.010366991,
-0.0007002103,
0.017698754,
-0.0045764497,
0.025334038,
0.0027384504,
-0.012747958,
0.010218602,
0.0061210436,
0.0076015606,
0.0039356793,
-0.013274065,
-0.017941572,
-0.005534233,
0.026426721,
-0.0071901185,
-0.00984763,
0.041575883,
0.008161391,
0.003834505,
-0.015945066,
0.011122425,
0.008572834,
0.004067206,
0.007635285,
0.009604811,
-0.006299785,
0.027357524,
-0.03903978,
-0.012471416,
-0.010960546,
-0.007911828,
-0.0038210151,
-0.024915852,
0.0015934948,
0.00024914165,
-0.00018485384,
0.0009130978,
-0.0073519973,
0.025860144,
-0.0038716022,
-0.0013675389,
-0.025212629,
-0.014434197,
-0.014272317,
-0.03350892,
-0.013645037,
0.024497664,
-0.021840153,
-0.008343506,
0.013658527,
0.007129414,
0.004117793,
0.0071563935,
-0.0023152046,
-0.0083637405,
0.035802204,
-0.009800415,
-0.013840641,
-0.010292796,
-0.054903906,
0.009705986,
0.000086630476,
0.030891879,
-0.030136444,
-0.017955061,
-0.002133091,
-0.0019745845,
-0.013577588,
0.017739223,
0.0052071027,
-0.014973792,
0.016241843,
0.009361993,
0.0029037017,
0.009517127,
-0.0055679576,
0.012363496,
-0.015243591,
-0.008916826,
-0.0029576614,
0.0014864188,
-0.008768437,
0.001473772,
-0.0032864776,
-0.008215351,
0.0023455569,
0.0016179453,
0.0013987344,
-0.014677015,
-0.0012452867,
0.01833278,
0.022730486,
0.001325383,
0.0265886,
0.006684247,
-0.015041242,
-0.013543863,
-0.017240096,
0.022069482,
0.010164642,
-0.012774939,
0.006903458,
-0.003537727,
-0.022757467,
-0.0049777743,
0.006626915,
-0.026723498,
0.016444191,
0.020491162,
-0.004019991,
-0.024025518,
0.012383731,
0.023108205,
0.013314535,
0.0098880995,
-0.016498152,
-0.02789712,
-0.010650279,
-0.009908334,
-0.017105198,
0.030163424,
-0.035478447,
-0.010326521,
0.029947584,
-0.0030031898,
-0.010306286,
-0.02637276,
-0.010211857,
-0.012430946,
0.015702248,
-0.015661778,
-0.029111212,
0.015216611,
-0.0064582913,
0.045272116,
0.032591607,
0.027654301,
0.019708749,
0.041575883,
0.018494658,
-0.0050722035,
0.014677015,
-0.005237455,
0.014191378,
0.0102388365,
0.018845394,
-0.0054195686,
-0.008060217,
0.02367478,
-0.023526391,
0.009409208,
0.009375483,
0.00770948,
-0.027168665,
-0.00095778314,
-0.032510668,
-0.019492911,
0.042466216,
-0.0051059285,
0.019034253,
-0.041360043,
-0.0070552193,
0.034372274,
0.009422697,
-0.0035276096,
0.0052914144,
0.02382317,
-0.030864898,
0.007952298,
0.0004078588,
-0.012869367,
0.00011382106,
-0.022514649,
0.014177889,
-0.004734956,
0.0013287555,
-0.006131161,
-0.01527057,
0.009874609,
-0.029515909,
-0.004148145,
-0.005132908,
-0.020126935,
-0.03644972,
-0.0022089717,
0.0016769636,
-0.027532892,
0.0014122243,
-0.023283573,
-0.034129456,
0.010171387,
0.023391493,
-0.009179879,
0.025954574,
0.010002763,
-0.041414004,
0.032537647,
-0.0034500428,
0.022622569,
-0.023485921,
0.022609077,
-0.0062694326,
-0.0026591972,
-0.054984845,
-0.0030318557,
0.0021566984,
0.017348016,
0.02096331,
0.031701274,
-0.021799684,
-0.012140913,
-0.007399212,
0.029057251,
-0.006235708,
-0.026278332,
0.019250091,
-0.012269067,
0.010056723,
-0.030028526,
-0.022109952,
-0.028571615,
0.015135672,
-0.0017722361,
0.0018261956,
0.008053472,
-0.007986023,
-0.014906343,
0.019897608,
-0.0063672345,
0.008262565,
0.014919833,
-0.030514162,
-0.016579092,
-0.01837325,
-0.00046371543,
-0.03062208,
-0.019074723,
0.019236602,
0.010218602,
0.013037992,
0.017847141,
0.0134966485,
-0.014771444,
-0.003692861,
-0.007439682,
0.029839667,
-0.0020808175,
-0.0020504652,
-0.0033269473,
0.028787455,
0.002183678,
-0.01259957,
0.015823657,
-0.02648068,
-0.014946813,
-0.0096790055,
0.026359271,
-0.0018548617,
0.005726464,
0.005041851,
-0.022150422,
-0.031539395,
-0.008727968,
-0.030945837,
0.016687011,
-0.033401,
0.00006023031,
-0.004920442,
0.021894112,
0.006137906,
0.0061277887,
0.0059052054,
-0.001218307,
0.031566374,
-0.023998538,
0.025927594,
0.0020639552,
-0.0051632603,
-0.012336517,
0.021988543,
-0.0088898465,
-0.016511641,
0.011061721,
0.008667263,
-0.015014263,
-0.0447595,
-0.018575598,
0.04314071,
0.031134697,
-0.026386252,
0.019209621,
0.0010336639,
0.010717728,
0.0011120739,
-0.018346269,
0.014353258,
-0.009969039,
0.010279306,
0.0104884,
-0.021394987,
-0.016052986,
0.012984032,
-0.0070889443,
-0.00055308605,
0.0068697333,
-0.048482712,
-0.023917599,
-0.0031819309,
-0.006330137,
-0.008539109,
-0.023378003,
0.012896348,
-0.019452441,
0.01116964,
0.009092195,
-0.0028817805,
-0.0061750035,
-0.013145911,
-0.008464915,
0.01833278,
-0.018683515,
-0.014784934,
-0.012221852,
-0.026804438,
-0.018831905,
-0.0074734064,
-0.023580352,
0.026615579,
0.0037232132,
-0.0063166474,
-0.017469425,
0.01821137,
-0.038230386,
0.015257081,
-0.010710984,
0.008647028,
0.013415709,
0.02935403,
-0.015864126,
0.0066538947,
0.000605781,
0.025725245,
0.0027704888,
-0.008026493,
0.008869612,
-0.005210475,
0.019681768,
-0.020733982,
-0.00840421,
-0.036638577,
0.019304052,
-0.029623827,
-0.01652513,
0.02242022,
-0.00557133,
0.010872862,
-0.0023421845,
-0.0022123442,
0.000022210916,
0.005699484,
0.020126935,
-0.022676528,
0.0014383609,
0.025374508,
-0.0011306226,
-0.012990776,
0.012801918,
0.004509,
0.01946593,
-0.013881111,
-0.0050283615,
-0.027128195,
-0.0040503433,
-0.0006791323,
0.017186137,
0.030109465,
-0.010016253,
0.025927594,
-0.008727968,
-0.012444436,
-0.0022949697,
-0.004202105,
-0.020019017,
-0.010171387,
0.002190423,
0.012471416,
0.00559831,
-0.020612571,
0.009665515,
-0.02076096,
0.0067989114,
-0.003834505,
-0.004768681,
-0.04349145,
0.014663525,
0.013044736,
0.0034045144,
-0.020072976,
0.0005501351,
-0.028571615,
-0.018912844,
0.008721222,
0.0075071314,
-0.0102388365,
-0.013854131,
-0.010791923,
0.002891898,
0.00029445929,
-0.039741255,
-0.01958734,
-0.00007556454,
0.010083702,
0.19781594,
-0.039687295,
-0.002905388,
-0.02092284,
-0.017267076,
-0.0036152941,
-0.017671773,
-0.026210882,
-0.013752957,
0.019641299,
0.020342775,
0.027263094,
0.005534233,
0.002991386,
0.0094159525,
0.0024534762,
-0.007129414,
0.0012933445,
-0.014771444,
0.003557962,
0.006761814,
-0.007412702,
0.030109465,
0.023553371,
0.03736703,
-0.0021347771,
-0.019344522,
0.012828898,
0.021597335,
-0.019681768,
-0.028490676,
0.010893097,
0.0056117997,
0.016538622,
-0.017280566,
0.012363496,
-0.01965479,
-0.012896348,
0.01537849,
0.0019054489,
-0.026656048,
-0.013064971,
-0.025954574,
0.009368738,
0.0014434196,
0.024740484,
0.007952298,
-0.03221389,
-0.0051767505,
0.01392158,
-0.030028526,
0.022609077,
-0.012006014,
0.013381984,
-0.0021314048,
0.0073047825,
0.0152840605,
0.011796921,
-0.004960912,
0.021921093,
-0.010022998,
0.0045663323,
-0.027978059,
0.038176425,
-0.01933103,
0.010049978,
0.002013368,
0.018939825,
0.01675446,
-0.0208419,
0.008734712,
0.005578075,
-0.021287067,
0.0059524197,
0.004242575,
-0.0075948155,
-0.00035621776,
0.021948073,
0.014137419,
0.013037992,
0.016457682,
0.00259512,
-0.03644972,
0.026170412,
-0.007129414,
-0.023054244,
0.009962293,
0.01193182,
-0.018710496,
-0.01680842,
0.0072036083,
-0.008734712,
0.0037400757,
0.00031490493,
0.006549348,
0.0011078583,
-0.0052745524,
0.012619805,
-0.013435944,
-0.03488489,
-0.019142173,
0.0813711,
0.016282313,
0.020639552,
-0.01973573,
-0.00048099936,
-0.013058227,
0.029057251,
0.008046728,
-0.0032713015,
0.0087144775,
-0.024605583,
-0.014339767,
-0.022851896,
-0.006738207,
0.024780953,
-0.0038041528,
-0.006009752,
0.026426721,
-0.020113446,
-0.021610824,
-0.020599082,
0.007803909,
0.03199805,
0.014744464,
0.012093699,
-0.029839667,
0.0031077366,
-0.017199626,
-0.014407217,
0.0053757266,
0.0061615133,
-0.025212629,
0.020153916,
0.005308277,
0.016363252,
-0.019884117,
-0.016052986,
-0.021961562,
0.003041973,
-0.03750193,
-0.016228354,
0.008741457,
0.013483158,
-0.00050502823,
0.00021236058,
0.03636878,
0.018535128,
-0.00839072,
-0.0112370895,
-0.01390809,
-0.01825184,
-0.015068222,
-0.019101704,
0.020383244,
-0.028139938,
-0.01674097,
-0.00012562472,
0.0026355898,
0.012747958,
-0.041629843,
0.0077701844,
0.02382317,
-0.005810776,
0.011048231,
-0.017766202,
-0.16997278,
0.008316525,
-0.004171753,
0.0015631425,
0.034210395,
-0.017820163,
-0.01676795,
-0.0018413718,
-0.014596076,
0.008620048,
0.022649547,
-0.004438178,
-0.025347529,
-0.010893097,
-0.0022949697,
-0.0026237862,
-0.01690285,
0.047889158,
0.025644306,
0.014407217,
0.009652026,
-0.03599106,
0.018130431,
-0.029111212,
0.005261062,
0.020545123,
0.0010218602,
-0.0051025557,
-0.011844135,
-0.016956808,
-0.014623055,
0.004799033,
0.010899842,
-0.0035613345,
-0.0016769636,
0.0018987039,
-0.0072170985,
-0.014083459,
-0.015486409,
0.032969322,
0.026939336,
0.031458456,
-0.019762708,
-0.0070889443,
-0.010778433,
0.04030783,
0.034318313,
-0.008997765,
0.024983302,
-0.0068731057,
0.02518565,
-0.022487668,
0.008147902,
0.025549877,
0.01953338,
0.014312787,
0.008862866,
0.019789688,
0.0099757835,
0.024834912,
0.023917599,
-0.013597823,
0.026804438,
0.01678144,
0.0054836455,
-0.04492138,
-0.023148675,
0.016295804,
-0.01953338,
-0.0006369764,
-0.015095202,
0.011527122,
0.04049669,
-0.03207899,
0.011061721,
0.01815741,
-0.014447686,
0.0015353196,
0.02254163,
0.021961562,
-0.003443298,
0.005068831,
-0.031647313,
-0.023499412,
-0.0014703994,
0.0058310106,
0.019830158,
0.029920606,
-0.03218691,
-0.014258828,
0.014542116,
-0.019384991,
0.0058310106,
-0.008134412,
0.0045663323,
0.027424974,
-0.0046675066,
-0.013469668,
-0.013476414,
-0.013537118,
0.020113446,
-0.013355005,
-0.024430215,
-0.012316282,
0.01532453,
-0.020315794,
-0.004458413,
-0.013071717,
0.026750479,
-0.011641786,
-0.013348259,
0.021961562,
0.00908545,
0.03650368,
-0.00659319,
0.020356264,
0.012140913,
-0.002969465,
-0.005146398,
-0.03073,
0.08104734,
0.0009889785,
0.010144407,
0.0367465,
0.0036827435,
-0.02781618,
-0.14741766,
-0.015594328,
0.012336517,
0.012093699,
0.004684369,
0.0003258655,
0.01258608,
0.041306082,
-0.023364512,
0.017240096,
-0.009510382,
-0.013752957,
-0.015486409,
-0.018872375,
0.024349276,
0.00700126,
0.013031247,
-0.00625257,
-0.00978018,
0.024726992,
0.00833676,
0.0010218602,
-0.01535151,
-0.005534233,
0.012538865,
-0.005669132,
-0.011371989,
0.014042989,
0.007871359,
0.031701274,
0.0009830768,
-0.009449678,
0.029381009,
0.0023489294,
-0.016052986,
-0.007223843,
-0.014326277,
-0.026143434,
0.029461948,
-0.01121011,
-0.017631304,
0.000609575,
-0.006741579,
-0.012693999,
0.00833676,
-0.00829629,
-0.00837723,
-0.007952298,
0.026575109,
-0.036638577,
-0.01957385,
-0.020720491,
-0.024592094,
-0.013712487,
0.022258341,
-0.0019509773,
0.0010623299,
0.034426235,
-0.01527057,
0.00086166756,
0.02924611,
0.0040638335,
-0.010744708,
-0.018089961,
0.02924611,
-0.001891959,
-0.02086888,
-0.024012027,
0.027708262,
-0.023539882,
0.021637805,
-0.0043032793,
-0.018130431,
-0.0058647357,
-0.0181709,
-0.0055443505,
-0.0029677788,
-0.003345496,
0.0001321589,
-0.01815741,
-0.027519403,
-0.010340011,
-0.0030824428,
-0.0060637114,
0.048536673,
-0.027236115,
0.027060745,
-0.02356686,
0.0073047825,
-0.0125591,
0.0024180652,
0.04198058,
0.000051140436,
-0.004411198,
-0.024322296,
0.008876356,
-0.005031734,
-0.008222096,
0.0072103534,
0.023998538,
-0.0015243591,
-0.0027080982,
-0.044381782,
-0.020329284,
-0.007567836,
0.014474667,
0.0058377557,
-0.0104142055,
-0.0037603106,
-0.042843934,
0.014366747,
0.0063200197,
-0.00028687122,
0.006255943,
-0.028058998,
0.006741579,
-0.028760474,
-0.024632564,
0.043518428,
-0.019722238,
0.029461948,
0.026170412,
-0.0048631104,
-0.017334526,
-0.0007689245,
-0.006033359,
-0.0142858075,
0.013746211,
-0.014582586,
0.018710496,
0.0011635042,
0.00245179,
0.007567836,
-0.045110237,
-0.021314047,
-0.0026693146,
-0.038743004,
-0.010083702,
-0.014650035,
0.02375572,
0.006181748,
0.018535128,
-0.012039739,
-0.005783796,
0.013705742,
-0.015729228,
0.005982772,
0.004947422,
-0.017226607,
0.0047079762,
0.020234855,
-0.006326765,
0.014555606,
0.018009022,
-0.0022949697,
-0.03202503,
-0.017401975,
0.017955061,
-0.0037670555,
-0.024780953,
-0.03858112,
-0.017955061,
0.015567348,
0.007662265,
-0.009550852,
0.011702491,
0.0066943644,
-0.0005745856,
-0.019411972,
0.014096949,
0.017482914,
-0.0059928894,
-0.017199626,
0.002219089,
-0.00698777,
-0.00980716,
0.02109821,
0.015122182,
-0.012511886,
0.0025630817,
0.0053689815,
0.024794443,
0.0195064,
-0.004778798,
-0.017685262,
0.012579335,
0.02530706,
0.0023910853,
-0.005399334,
0.001849803,
-0.005308277,
-0.0005669975,
-0.014339767,
0.016133925,
0.0040166187,
0.01191833,
-0.009132665,
0.023445452,
-0.010872862,
0.020518143,
0.0068967133,
0.03075698,
-0.0034972574,
0.0006812401,
0.005443176,
0.0028817805,
-0.02363431,
0.02509122,
-0.032537647,
-0.0251182,
-0.02080143,
-0.005281297,
-0.007257568,
0.014946813,
0.0075813257,
0.009652026,
-0.016309293,
0.020518143,
0.004650644,
-0.009948804,
-0.0127614485,
0.009935314,
0.019924587,
0.02228532,
-0.007864614,
-0.0028784082,
0.013800171,
0.013645037,
0.0098880995,
-0.014123929,
0.008464915,
-0.028625574,
0.016295804,
-0.034588113,
-0.03742099,
-0.016201373,
-0.0059220674,
-0.01396205,
0.028328797,
0.009874609,
-0.023189144,
0.08077754,
0.011689002,
-0.026979806,
-0.0073115276,
-0.012336517,
0.017982041,
-0.0056893667,
0.0046607614,
-0.011689002,
-0.051936127,
0.016039494,
-0.0038075252,
0.028787455,
-0.03372476,
-0.028895373,
0.0195064,
-0.0035309822,
-0.0044415505,
-0.011324774,
-0.010319776,
0.0082828,
-0.009436187,
-0.009874609,
0.024821423,
-0.026885377,
0.016619561,
0.01259957,
-0.00073941535,
-0.00079000246,
-0.015594328,
0.0033286337,
-0.019452441,
-0.035883144,
-0.0279241,
0.03191711,
-0.009247329,
-0.014204868,
-0.043734267,
-0.00058090896,
0.024942832,
-0.014933323,
0.022703508,
-0.012734469,
-0.018764455,
0.022528138,
-0.011021251,
-0.0362069,
-0.004252692,
-0.0037738006
] |
The airways of the lung develop through a reiterative process of branching morphogenesis that gives rise to the intricate and extensive surface area required for postnatal respiration. The forkhead transcription factors Foxp2 and Foxp1 are expressed in multiple foregut-derived tissues including the lung and intestine. In this report, we show that loss of Foxp2 in mouse leads to defective postnatal lung alveolarization, contributing to postnatal lethality. Using in vitro and in vivo assays, we show that T1alpha, a lung alveolar epithelial type 1 cell-restricted gene crucial for lung development and function | [
0.009578609,
0.015880326,
-0.013326472,
-0.021386035,
-0.01890515,
0.006998222,
-0.039004307,
0.022022841,
-0.00879587,
-0.01187376,
0.022699445,
-0.00074749964,
0.025830405,
0.018347945,
-0.010348082,
-0.032928128,
0.02486193,
-0.01980729,
-0.025631402,
0.0037976133,
-0.015190453,
0.008722902,
-0.010268481,
-0.023535253,
-0.007714628,
0.011714559,
0.025060931,
-0.028523559,
-0.01594666,
-0.033219997,
0.020921698,
0.008324899,
-0.0041856663,
0.0044808523,
0.008119264,
0.003212217,
-0.0013565273,
-0.010905286,
0.013001436,
0.0004494119,
0.018785749,
0.0145934485,
-0.0038606306,
0.015867058,
-0.019104151,
-0.0066367025,
0.011615058,
-0.017432537,
-0.0033681015,
0.001966799,
-0.010374615,
0.004785988,
-0.0059003965,
-0.021027833,
-0.022314709,
-0.0076615606,
0.009439308,
0.012338097,
0.0037777133,
-0.0054261093,
-0.010712918,
0.007396225,
-0.021558503,
-0.00074211,
-0.019263351,
0.024888463,
-0.017352937,
0.028205156,
0.009087739,
0.0051043904,
0.044072215,
0.015429256,
0.0017561889,
-0.0021193668,
0.016742665,
0.013651508,
-0.0077477945,
0.0101424465,
-0.02995637,
0.01306777,
0.0063481503,
-0.006066231,
-0.011011421,
0.050891336,
0.022447377,
-0.013678041,
-0.01050065,
0.011741092,
-0.0015107536,
0.019263351,
0.02017876,
0.018759215,
0.033113863,
0.023906723,
-0.01569459,
-0.00091789477,
-0.012092662,
0.024463927,
-0.0016542006,
-0.054499898,
-0.011780893,
0.013061137,
-0.02815209,
-0.0052967584,
-0.02995637,
0.008981604,
0.00977761,
0.0021027832,
0.018507145,
-0.01569459,
-0.022725979,
0.022487178,
0.011668125,
-0.019263351,
0.021850372,
-0.02354852,
0.021107433,
0.013120837,
-0.0069915885,
0.00548581,
0.03513041,
0.009392874,
0.0008486588,
-0.018467346,
0.019329686,
0.007183957,
-0.0074890926,
0.0016931717,
-0.01836121,
-0.01935622,
0.023070915,
-0.012158996,
0.044894755,
0.008550434,
-0.029399166,
0.015959926,
-0.014964919,
-0.010454216,
-0.017273337,
-0.02580387,
0.0015231912,
0.012304931,
-0.00549576,
0.0014759284,
-0.0066897697,
0.022009574,
0.017140668,
-0.008915271,
0.023031116,
-0.016623264,
0.011183889,
-0.027780619,
0.009512275,
-0.015230253,
0.018878616,
0.024596594,
0.0026450625,
0.024928264,
-0.012384531,
-0.010752718,
0.0058771796,
-0.012610067,
0.0019070983,
0.017485606,
0.017047802,
0.020656364,
0.023535253,
0.015508856,
0.0077079944,
-0.0059468304,
0.009817411,
-0.0065902686,
-0.041684195,
0.011581891,
0.012437598,
0.0010837294,
-0.014951651,
0.009193873,
-0.03603255,
-0.008696369,
0.0045272857,
0.022367777,
0.01471285,
-0.003192317,
-0.023203583,
0.003402927,
0.016052794,
-0.009625043,
-0.011024687,
-0.03534268,
0.0005862255,
0.019993024,
0.021346236,
-0.0294257,
-0.63807863,
-0.013485673,
0.030513573,
-0.02457006,
0.018679615,
0.036748957,
-0.014978185,
-0.01869288,
-0.00932654,
0.015309854,
-0.012251863,
0.0027744137,
0.027090747,
-0.0014344697,
-0.014036244,
-0.032450523,
-0.008523901,
-0.0143811805,
0.032317854,
-0.0021027832,
-0.002301785,
-0.000861511,
0.0071043563,
0.021253368,
-0.00465332,
0.035024278,
0.044072215,
-0.02070943,
0.0076947273,
0.0053962595,
-0.025379334,
0.023734255,
0.0004577036,
0.0075753266,
0.04906052,
-0.00632825,
-0.026984613,
0.021399302,
0.01512412,
0.024755796,
-0.010361348,
0.014394447,
0.03205252,
0.0023780689,
-0.02358832,
0.009525542,
0.018586747,
0.01142269,
0.025220133,
-0.014991452,
-0.011986528,
-0.00252732,
-0.011999795,
0.008703002,
0.008245299,
0.013299938,
0.029876769,
-0.017525405,
0.012901935,
-0.008205499,
-0.01351884,
0.028576626,
-0.014354647,
-0.012304931,
0.02066963,
0.004553819,
-0.0043349178,
0.0006280987,
0.013299938,
-0.010487383,
0.008829037,
0.040835124,
0.0020480577,
0.018785749,
0.010460849,
0.028815428,
-0.016278328,
-0.007880462,
-0.0002788095,
0.02059003,
-0.009412774,
0.015309854,
-0.017936675,
0.023123983,
0.039190043,
0.004003248,
-0.030752376,
0.0076151267,
-0.01467305,
0.021717705,
-0.0016815633,
0.0028092389,
0.0075952266,
-0.03528961,
-0.009585243,
0.026374342,
-0.0071043563,
0.01722027,
-0.0012586849,
-0.022182042,
-0.005051323,
-0.012099296,
0.011561992,
-0.010626684,
0.030858511,
0.0032569924,
-0.021545237,
-0.0049849893,
0.024331259,
-0.024477193,
-0.03706736,
-0.013890309,
-0.0043680845,
-0.02194324,
0.01594666,
-0.021837106,
0.0010596834,
-0.009923545,
-0.02613554,
-0.023455651,
0.034360938,
-0.016012993,
-0.005247008,
-0.019342953,
0.021041099,
0.018679615,
-0.008006496,
-0.0018175477,
0.0066367025,
0.0030496991,
-0.0134591395,
-0.003976715,
0.004285167,
-0.026453942,
0.010885386,
-0.00799323,
0.025286466,
0.009770977,
0.0044311015,
-0.027674485,
-0.035316147,
-0.0017163885,
0.010029679,
-0.01316727,
-0.014022977,
-0.0168886,
-0.014566915,
0.008225398,
0.0039899815,
0.014619982,
-0.0072303903,
-0.013678041,
-0.016702866,
0.019634822,
0.0293461,
-0.0021807256,
0.0040795323,
-0.014288313,
-0.0019137318,
-0.016848799,
-0.0020032825,
0.0138372425,
-0.0012387848,
-0.008298365,
-0.00920714,
0.0047992547,
-0.010507283,
0.00549576,
0.022314709,
-0.034175202,
-0.0019933325,
-0.022672912,
-0.010872119,
-0.001139284,
0.013505573,
-0.0021707756,
0.0010513916,
-0.011396157,
-0.009499009,
-0.018241812,
0.0063017164,
-0.026745811,
0.017843807,
0.0041193324,
0.0031243246,
0.01594666,
0.021027833,
0.002646721,
0.004338234,
0.03555495,
-0.016556932,
0.023389319,
-0.03624482,
0.024623128,
0.013678041,
-0.02321685,
0.013226971,
0.024954798,
-0.011767627,
0.03154838,
-0.0049750395,
-0.04051672,
0.012901935,
-0.008331533,
0.031654518,
-0.034387473,
-0.017326403,
-0.017883608,
-0.015110853,
0.0024626444,
-0.010679751,
0.0035488612,
0.0031392497,
-0.0071905903,
-0.005757779,
0.004815838,
-0.010978254,
-0.0029933152,
-0.008457567,
-0.024384325,
-0.019488888,
0.0042188335,
0.020019557,
0.020722697,
-0.008908637,
-0.0073166243,
-0.000046019115,
0.0026964713,
0.012935102,
-0.020722697,
-0.0039269645,
0.0074360254,
0.006640019,
0.0012180555,
-0.014646515,
0.009505642,
0.025578335,
-0.011223689,
0.020775763,
0.016119128,
0.0019651405,
-0.0012760976,
-0.00057710457,
0.011601792,
0.005021473,
-0.018944949,
0.024636395,
-0.017326403,
-0.024026124,
-0.022381043,
0.0060993982,
0.0023730937,
0.010341449,
-0.008265198,
-0.000995837,
-0.01107112,
0.021598304,
0.012590166,
0.027833687,
0.00801313,
0.00504469,
-0.015973194,
0.0027545134,
-0.024888463,
0.0065703685,
0.01935622,
-0.022938248,
-0.00025144676,
-0.027568351,
-0.018852083,
-0.03672242,
0.0007429392,
0.032291323,
-0.032238256,
0.027104015,
0.010387882,
-0.010321548,
-0.0053697256,
0.004069582,
0.017684607,
-0.0010928503,
-0.027701018,
0.03534268,
0.039879914,
-0.016676331,
-0.0019402653,
-0.0025439034,
-0.007654927,
-0.0031060828,
0.013379539,
0.0127162,
-0.008145798,
0.009598509,
-0.00418235,
-0.014049511,
-0.0037080627,
0.009353074,
-0.0069252546,
0.019409286,
-0.012842235,
-0.007429392,
0.009227039,
-0.015800726,
-0.0020546913,
0.05227108,
0.0028656225,
-0.027196882,
-0.012364631,
-0.017008001,
-0.014354647,
-0.015455789,
-0.033007726,
-0.006898721,
-0.010659851,
-0.008789236,
-0.014487314,
-0.001541433,
-0.0072967242,
0.03993298,
-0.013386172,
-0.028417425,
-0.022301443,
0.011588525,
0.006218799,
0.012391165,
0.03138918,
-0.015270054,
0.025777336,
-0.010852219,
-0.014129112,
-0.008663202,
-0.009684743,
0.0052569583,
-0.013293305,
-0.0009734494,
0.012795801,
0.014726116,
0.008915271,
0.014102578,
0.021611571,
-0.009459208,
-0.013100937,
-0.029558366,
-0.0078008617,
-0.014221979,
0.0087560695,
0.02913383,
0.018679615,
0.009863844,
0.002397969,
0.016238527,
0.033219997,
0.005316659,
-0.025060931,
-0.0065736854,
0.0071308897,
0.0008013959,
0.024901731,
0.01138289,
-0.00632825,
0.005983314,
-0.0005787629,
-0.003953498,
0.01610586,
-0.012152363,
0.020032825,
0.011077754,
0.0017346303,
0.006673186,
-0.0039369143,
-0.012304931,
-0.0010829002,
0.0028506976,
-0.028868495,
0.015389455,
-0.023986323,
-0.01836121,
-0.014991452,
0.02453026,
0.009631676,
0.023322985,
-0.012629966,
0.0123248305,
-0.025604868,
-0.011634959,
-0.035926417,
-0.005011523,
-0.0013217021,
0.008749436,
-0.02793982,
0.005174041,
0.0087560695,
-0.031017711,
-0.023986323,
0.01312747,
-0.014845517,
-0.030433973,
-0.003996615,
0.036350954,
0.044496752,
0.023641387,
-0.0068191206,
0.01890515,
0.008411133,
0.006805854,
-0.019303152,
-0.0014187153,
-0.0056217946,
0.004417835,
0.001867298,
0.0023034432,
-0.023362784,
-0.0064343843,
0.0111905215,
0.01906435,
-0.009293374,
-0.00042992632,
-0.0021276586,
-0.004689804,
0.014739383,
0.028178623,
0.027249949,
-0.008981604,
-0.019051084,
-0.014261779,
-0.012842235,
-0.020165492,
-0.026016138,
-0.02051043,
-0.010885386,
0.014288313,
-0.008026397,
-0.024609862,
-0.014500582,
0.015044519,
0.0014850493,
0.020245094,
0.010872119,
0.014938384,
0.029664502,
-0.013041236,
0.025127266,
-0.00079807924,
-0.009784244,
0.00760186,
-0.010666484,
0.011495657,
0.015641524,
-0.036085617,
0.010480749,
0.0013946693,
-0.01631813,
-0.016384462,
0.015455789,
-0.0019153901,
0.017061068,
0.03024824,
-0.025007864,
-0.015734391,
0.0032636258,
-0.0058274292,
-0.0015870376,
-0.011170622,
-0.01298817,
-0.017326403,
0.016941667,
0.020696163,
-0.022513712,
0.037093893,
-0.028045954,
-0.008172331,
0.02732955,
0.0086698355,
-0.00058995676,
-0.016981468,
0.004318334,
0.0023996274,
-0.020351227,
-0.02921343,
-0.045345824,
0.0021575086,
-0.039826848,
0.0070778225,
0.019197019,
0.02732955,
0.011641592,
0.026387608,
0.028497025,
-0.01228503,
0.017525405,
-0.015760925,
0.036616288,
-0.011416057,
0.022248376,
0.015588457,
-0.007780961,
0.025206866,
-0.006553785,
0.014686316,
0.017910141,
-0.03003597,
-0.008610135,
0.020948231,
-0.012338097,
-0.035369214,
-0.0016707841,
-0.01598646,
0.0040861657,
-0.04088819,
0.00934644,
0.026321275,
-0.012875401,
0.000756206,
-0.0058042123,
0.015296588,
-0.022221843,
0.016809,
-0.010812419,
0.01639773,
-0.0015820625,
-0.03682856,
-0.0023631437,
-0.024954798,
0.00019495936,
-0.005694762,
0.008868837,
-0.009061205,
-0.004912022,
0.009525542,
0.0023631437,
-0.0143811805,
-0.007920262,
-0.02617534,
-0.012364631,
-0.020165492,
-0.03003597,
0.009273473,
-0.047070507,
0.015442522,
0.015270054,
-0.005409526,
0.03640402,
-0.00805293,
-0.020762498,
0.0053896257,
-0.020085892,
0.027754085,
-0.016278328,
0.015561922,
0.01898475,
-0.016158927,
-0.032768924,
-0.036350954,
0.006693086,
-0.005601894,
0.028788894,
0.022991315,
-0.0103082815,
-0.005117657,
-0.0021608253,
0.028868495,
-0.017883608,
-0.022818847,
0.0015629915,
-0.017233536,
0.002283543,
-0.004759454,
-0.018109143,
-0.024331259,
0.0024327943,
-0.021173768,
0.01226513,
-0.020032825,
-0.022115707,
-0.01467305,
0.011508924,
-0.006978322,
-0.0015754291,
0.0066035353,
0.015813991,
0.0004062949,
-0.016251795,
-0.03603255,
0.003681529,
0.011615058,
0.023601586,
-0.006109348,
0.033883333,
0.015867058,
0.0075952266,
-0.032848526,
-0.0037611297,
-0.017485606,
0.046035696,
-0.0020795665,
-0.017963208,
-0.027011147,
0.014407714,
0.0086698355,
-0.029691035,
0.0002257424,
-0.02009916,
-0.0060098474,
-0.013193804,
0.036430553,
-0.0038506803,
-0.00039240622,
-0.00096101174,
-0.016371196,
0.002067958,
-0.019329686,
-0.027090747,
0.009240306,
-0.04301087,
-0.006513985,
0.018427545,
0.012556999,
0.012019695,
0.004795938,
-0.020988032,
-0.017605005,
0.029717568,
-0.026387608,
0.016609998,
0.008921904,
-0.0015928417,
-0.023031116,
0.018241812,
0.0038805306,
-0.025405867,
0.006208849,
-0.03977378,
-0.015681325,
0.011303289,
0.0007358912,
0.0024510361,
-0.0078008617,
-0.0056582782,
0.012271764,
0.012304931,
0.0044874856,
0.0041425494,
0.020536963,
0.017644806,
-0.0060430146,
0.00005363714,
0.008530534,
-0.0022968098,
-0.0074360254,
0.003704746,
-0.0063183,
0.017233536,
-0.020868631,
0.005870546,
0.0036417288,
0.0081258975,
-0.020205293,
0.0035455446,
-0.027011147,
0.009392874,
-0.03138918,
0.015110853,
-0.0071308897,
-0.010566983,
-0.023986323,
0.017180469,
-0.01763154,
0.0050712232,
-0.025512002,
-0.007807495,
0.02695808,
-0.021332968,
-0.03048704,
-0.008862203,
-0.013916844,
0.033697598,
0.024649661,
-0.029770635,
-0.0012097637,
0.005223791,
-0.040941257,
-0.014434247,
0.0020729331,
0.016676331,
-0.012510565,
-0.0013158979,
-0.0027312965,
0.0098041445,
-0.013154004,
0.017021269,
-0.0022238425,
-0.024065923,
0.016503863,
0.002111075,
0.01841428,
-0.0047130208,
-0.0294257,
-0.024172058,
0.030168638,
0.010487383,
-0.0019021233,
0.00879587,
-0.042506736,
0.02568447,
-0.02374752,
0.017352937,
0.0024775695,
0.03032784,
0.0038473636,
0.003288501,
-0.0016359588,
0.015641524,
0.0076151267,
-0.002159167,
0.011940095,
-0.001115238,
0.038473636,
0.0024178692,
0.0018921733,
-0.008656569,
0.028497025,
-0.016012993,
0.040994324,
0.009313273,
-0.009956712,
0.026162073,
0.019382752,
-0.00053730427,
-0.026268208,
-0.014129112,
-0.024662929,
-0.006736203,
-0.0006931888,
-0.009545442,
-0.018095877,
0.012530466,
0.0005115999,
-0.031097312,
0.0049849893,
-0.004490802,
-0.007754428,
-0.01012918,
0.012875401,
-0.012125829,
0.0029833652,
-0.009227039,
0.0020646413,
-0.001953532,
-0.020576762,
0.0038374136,
0.0063448334,
-0.015508856,
0.0125768995,
-0.013492307,
-0.009532175,
-0.002867281,
-0.009651576,
-0.026400875,
-0.005558777,
0.016941667,
0.17904834,
-0.0073497915,
-0.00076201017,
-0.004772721,
0.017167203,
-0.015800726,
0.0005949318,
0.009857211,
-0.021332968,
0.0057047117,
0.0022619846,
0.003714696,
-0.009445941,
0.0036085618,
0.033564933,
-0.022221843,
-0.026798878,
0.0027031046,
-0.023654653,
-0.006825754,
0.016835533,
-0.016384462,
0.038367502,
0.01138289,
0.0421618,
0.004006565,
-0.03390987,
-0.00030202634,
0.009843945,
0.0029137146,
-0.021797305,
0.025047664,
-0.0038639472,
0.0022503762,
-0.021638105,
-0.0023200267,
0.006931888,
-0.003455994,
0.0026782295,
-0.00013805734,
0.019130684,
0.0083381655,
0.0021309752,
0.005270225,
-0.020085892,
0.03364453,
-0.00420225,
-0.006513985,
0.0054360596,
-0.00511434,
-0.032397456,
0.03735923,
0.009021404,
0.019913424,
-0.009591876,
-0.017140668,
0.005001573,
0.019263351,
0.0022238425,
0.02662641,
-0.0066765025,
0.026440676,
-0.0337772,
0.029770635,
-0.008172331,
0.024410859,
-0.016676331,
0.0016616632,
0.013286672,
-0.029770635,
-0.008590234,
-0.0008084439,
-0.013273405,
0.02033796,
-0.025193598,
-0.036748957,
0.015256787,
0.01606606,
0.0045438693,
0.02815209,
0.022593312,
-0.024477193,
-0.041843396,
-0.009479108,
-0.0069186212,
-0.027966354,
0.028656226,
0.030089037,
-0.015429256,
-0.039747246,
-0.003054674,
-0.016490597,
-0.009439308,
0.006185632,
0.013532107,
-0.020643096,
-0.0043017506,
0.021120701,
-0.007376325,
0.019051084,
-0.02929303,
0.058002327,
-0.0015646499,
0.0075089927,
0.003844047,
0.0017578473,
-0.00509444,
0.02317705,
-0.0046931203,
-0.012994803,
0.0034062436,
0.00018148529,
-0.00096764514,
-0.012550366,
0.0063680504,
0.010600151,
0.0052868086,
-0.01516392,
0.0042520002,
-0.0051242905,
-0.0022802264,
-0.023057649,
0.012357998,
0.017406004,
-0.007754428,
-0.012948369,
-0.02494153,
0.0047694044,
-0.010261848,
-0.033299595,
0.0014145696,
-0.0132070705,
0.00084161083,
0.0064178007,
0.0008449275,
-0.018374478,
-0.0035389112,
-0.018255077,
-0.008550434,
0.032742392,
-0.0210809,
-0.00004640779,
0.010586884,
-0.001106117,
0.0153496545,
-0.008344799,
0.018958217,
0.007741161,
-0.01779074,
0.0008241982,
-0.013538741,
-0.009571976,
-0.0053465087,
-0.0041723996,
0.01516392,
-0.026692744,
-0.00424205,
-0.013366273,
0.018745948,
-0.013193804,
-0.0075421594,
0.0037976133,
-0.011561992,
-0.0075421594,
-0.013299938,
-0.02292498,
-0.16705519,
0.0003403756,
0.011369623,
0.0049518226,
0.018878616,
0.016981468,
0.003154175,
-0.010374615,
-0.0071972236,
0.014726116,
0.036350954,
0.010003146,
-0.013770909,
-0.02070943,
0.01775094,
-0.010858852,
-0.020881899,
0.025949804,
0.014858784,
-0.0049617724,
0.040171783,
-0.014208713,
0.0138372425,
0.00026575002,
0.0029186897,
0.006805854,
0.013260138,
-0.00062187994,
0.0027279798,
-0.018732682,
-0.019449087,
-0.0033183512,
0.046539836,
0.00086234015,
0.016357929,
-0.0067096697,
-0.0015994752,
-0.03237092,
-0.0074559255,
0.029027697,
0.024954798,
0.03600602,
0.0022371092,
-0.014646515,
-0.029558366,
-0.0034062436,
-0.006381317,
0.007469192,
0.0338568,
0.005940197,
0.018626546,
-0.013240238,
-0.00080595637,
0.015004719,
0.021332968,
-0.005472543,
0.0016193753,
0.017193737,
-0.0058804965,
-0.017074335,
-0.0011268464,
-0.012769268,
0.019913424,
0.009790877,
0.013598441,
-0.031176914,
-0.022526978,
0.02219531,
-0.045637693,
-0.0052868086,
-0.0019137318,
-0.013638241,
0.021876907,
-0.0034427273,
0.015827259,
0.020112425,
-0.022871913,
0.007986597,
0.022646379,
0.015734391,
-0.013100937,
0.013001436,
-0.025618136,
0.011727826,
-0.014951651,
0.015402721,
0.00020200733,
0.011077754,
-0.0061060316,
-0.011163988,
0.008736169,
-0.012782535,
-0.019289887,
-0.010029679,
0.033697598,
0.030089037,
-0.0006998222,
-0.030301306,
-0.0030563325,
0.00048050587,
0.026148807,
-0.028682759,
-0.021279901,
0.013406073,
0.041259658,
-0.002235451,
-0.01890515,
0.037465364,
0.06734213,
-0.018308144,
-0.017326403,
0.0019551904,
0.004026465,
0.013678041,
-0.00069733465,
0.016689599,
-0.002991657,
-0.0037843466,
0.020231826,
-0.026188606,
0.058957532,
-0.0019037817,
0.015959926,
0.04454982,
-0.003278551,
-0.014460781,
-0.12035615,
-0.032264788,
0.018454079,
0.031283047,
-0.03250359,
0.0054161595,
-0.021717705,
0.009897011,
-0.02437106,
0.01861328,
0.001201472,
-0.028099023,
-0.0018424229,
-0.004795938,
0.015110853,
0.0018158894,
0.019449087,
-0.005356459,
-0.0112767555,
0.030805442,
-0.01898475,
0.0038042467,
0.009081105,
-0.016357929,
-0.014898584,
-0.023137249,
-0.026891746,
0.009200506,
0.017021269,
0.0017893558,
0.019648088,
-0.015734391,
0.034254804,
-0.011077754,
-0.0006169049,
-0.020802299,
0.02317705,
-0.020205293,
0.04171073,
-0.00965821,
-0.00032109732,
0.0045903027,
0.0012993144,
-0.0071043563,
-0.01800301,
-0.005442693,
-0.018440813,
0.0066234358,
0.02801942,
-0.014699583,
-0.025963072,
-0.03505081,
-0.008902004,
-0.021638105,
0.021797305,
-0.0043780347,
0.008006496,
0.019435821,
-0.0063216165,
0.0023847022,
0.023070915,
-0.004600253,
-0.031654518,
0.0015198746,
0.023893455,
-0.014076045,
-0.014328113,
-0.044602886,
0.02815209,
-0.031283047,
-0.014434247,
0.0004937727,
0.003313376,
-0.0027611468,
-0.032291323,
-0.013280038,
-0.015654791,
-0.0067660534,
0.011986528,
-0.02568447,
0.0030098988,
-0.02153197,
0.009877112,
-0.02366792,
0.022646379,
0.035608016,
0.017180469,
-0.018626546,
-0.00012924738,
-0.012344731,
-0.011581891,
0.033618,
0.015004719,
-0.005237058,
-0.021585038,
0.007004855,
0.016039526,
0.0052635917,
0.0031757334,
0.021293169,
-0.02658661,
-0.014062778,
-0.056940984,
0.0017147302,
0.0074758255,
-0.007276824,
0.009339808,
-0.0062121656,
0.02662641,
-0.014487314,
-0.0023780689,
0.015813991,
-0.013505573,
0.002301785,
0.0012512223,
-0.000022232207,
-0.0048224716,
-0.004557136,
0.025604868,
0.014301579,
0.00675942,
0.027807154,
0.03489161,
0.010354715,
-0.00158455,
-0.005157457,
-0.022128975,
-0.028895028,
-0.019780757,
0.008019763,
-0.0025588286,
0.0140893115,
0.000020910713,
-0.042347535,
-0.0074360254,
0.007091089,
-0.00887547,
-0.019913424,
0.00028523558,
0.007754428,
0.018467346,
0.03446707,
0.004494119,
-0.026666211,
0.016450796,
-0.0003899187,
0.0169682,
-0.0036052451,
-0.022898447,
0.007979963,
0.01557519,
-0.006696403,
0.023521986,
0.0009411116,
-0.006911988,
-0.011880394,
-0.0063979006,
-0.0073497915,
0.013877043,
-0.00797333,
-0.010056213,
-0.02059003,
0.0379695,
0.012948369,
0.019926691,
0.0056217946,
0.005714662,
-0.02243411,
-0.006825754,
0.0004423639,
0.00038867493,
-0.036642823,
-0.014739383,
-0.03040744,
0.009054571,
0.015853792,
0.027143814,
0.017087601,
-0.015296588,
0.0044775354,
-0.018838815,
0.044496752,
0.04171073,
0.002656671,
-0.03521001,
0.012809068,
0.032105587,
-0.0037511797,
-0.020085892,
0.011993161,
-0.009863844,
0.027966354,
-0.005227108,
0.015415989,
-0.0010538792,
0.008185598,
-0.0018308144,
-0.008928537,
0.008749436,
0.0079136295,
-0.0024842029,
0.0116548585,
0.0040662657,
0.0045737196,
-0.001009933,
-0.01898475,
-0.021929974,
0.0054062093,
-0.013041236,
-0.044894755,
-0.010978254,
0.0031674416,
0.0056383777,
0.018401012,
-0.0019120735,
0.00055513147,
-0.023840388,
0.0071242563,
-0.009220406,
-0.0101424465,
-0.004729604,
0.019979758,
0.015084319,
0.017764207,
-0.0064211176,
-0.018812282,
-0.013890309,
0.006663236,
0.04218833,
-0.02584367,
0.027594885,
0.003034774,
0.012192163,
0.013823976,
-0.051103603,
-0.007469192,
0.022526978,
0.0069451546,
0.029611435,
0.02206264,
-0.037996035,
0.095149286,
-0.002742905,
-0.04163113,
-0.009193873,
-0.0129550025,
0.027276482,
-0.001033979,
0.008424399,
0.009240306,
-0.027621418,
0.004049682,
-0.033803735,
0.0074824593,
-0.0108986525,
-0.010268481,
0.018480612,
-0.0027926555,
-0.017565206,
0.006736203,
0.006371367,
0.012915202,
0.0014958285,
0.009744444,
0.022818847,
-0.054022294,
0.0053299256,
0.030380907,
0.011203788,
0.00465332,
-0.0071242563,
0.0017628223,
0.0033050845,
-0.043408874,
-0.0052204747,
0.01312747,
-0.0050380565,
-0.002910398,
-0.013916844,
0.017021269,
0.030752376,
0.018666347,
0.0005758608,
-0.023919988,
-0.016132394,
-0.02037776,
0.00031757334,
0.0047428706,
-0.0014187153,
-0.026361074
] |
Protein synthesis in all organisms is catalyzed by ribosomes. In comparison to their prokaryotic counterparts, eukaryotic ribosomes are considerably larger and are subject to more complex regulation. The large ribosomal subunit (60S) catalyzes peptide bond formation and contains the nascent polypeptide exit tunnel. We present the structure of the 60S ribosomal subunit from Tetrahymena thermophila in complex with eukaryotic initiation factor 6 (eIF6), cocrystallized with the antibiotic cycloheximide (a eukaryotic-specific inhibitor of protein | [
-0.013512366,
-0.032053187,
-0.024123698,
-0.02764362,
-0.0048866286,
0.0022128434,
-0.0010709646,
0.009167263,
-0.011185093,
-0.009051222,
0.004277412,
0.0043193153,
-0.0043193153,
-0.016245784,
0.009347772,
-0.009547621,
0.027514685,
-0.011352709,
-0.009083456,
0.009960213,
-0.018540822,
0.007052733,
0.002137094,
-0.030789629,
0.015317453,
0.021738406,
0.006163083,
-0.027669406,
0.0015174013,
-0.028081996,
-0.014466483,
-0.0033361877,
-0.018179806,
-0.0033104008,
-0.009231731,
-0.010366357,
0.018592397,
0.0062791244,
0.0013691263,
0.017328836,
0.044173058,
0.013538153,
-0.011662152,
0.012796778,
-0.0043999,
0.015446388,
-0.0010991691,
0.02090033,
-0.018914733,
0.019185496,
-0.0027833798,
0.0032507684,
-0.0039163944,
-0.02374979,
-0.022099422,
-0.02546462,
-0.02160947,
0.0063468153,
0.01563979,
-0.013796022,
-0.0073686233,
0.0039099474,
-0.024691012,
0.00913503,
0.005315337,
0.010218082,
0.02230572,
0.019404685,
0.0038680437,
0.003887384,
0.034709245,
0.008174466,
-0.012390633,
0.025000457,
0.017548025,
-0.036591694,
-0.024304207,
-0.014505164,
-0.00765228,
0.020384591,
0.0077941082,
-0.011133519,
0.008896501,
0.010662907,
-0.008735332,
-0.012558249,
0.0013038531,
0.010334124,
-0.021209773,
0.0012506675,
0.029293984,
0.05941315,
0.030144954,
0.0121714445,
-0.01686467,
-0.0013812139,
-0.0046255356,
0.025438834,
-0.0011314028,
-0.036746416,
-0.010114934,
0.010708034,
0.0036907583,
-0.014118359,
-0.010572652,
0.015562429,
-0.01623289,
-0.017960615,
0.01901788,
-0.01508537,
-0.007645833,
0.039118815,
-0.008548376,
-0.024110805,
0.03017074,
-0.00500267,
0.03171796,
0.011597685,
0.008703099,
-0.014891968,
0.00943158,
0.014891968,
0.0052154125,
-0.027514685,
0.041259132,
-0.022976179,
0.010172955,
0.00047544704,
0.0003467137,
0.021183986,
0.01478882,
0.01563979,
-0.0150982635,
0.01931443,
0.0050768075,
0.00004338958,
-0.01571715,
-0.019069456,
-0.00079858984,
-0.031666383,
0.027566258,
0.019391792,
-0.013499472,
0.0027398644,
0.0050510205,
0.0025174518,
0.028417228,
0.023479026,
0.0028156135,
0.021815766,
0.022782777,
-0.014376229,
0.010836969,
-0.014801714,
-0.0020081594,
0.02764362,
-0.01856661,
0.041336495,
-0.0048672883,
-0.0053669107,
0.01730305,
0.001979149,
0.006736843,
-0.01445359,
0.02449761,
0.027488897,
0.0247168,
0.0031234452,
-0.0008598339,
0.0022595823,
-0.022989074,
0.00079294894,
-0.011629918,
0.026560567,
-0.015510855,
0.0073170494,
0.014118359,
0.00856127,
-0.026225336,
-0.009167263,
0.02119688,
-0.0034490055,
0.019997787,
0.006678822,
0.0016398893,
0.0047448003,
0.018682651,
-0.013396325,
0.029061902,
-0.012287485,
-0.021635259,
0.015472175,
0.010140722,
-0.012622716,
-0.63869137,
-0.034992903,
0.011668598,
-0.045488194,
0.0017954169,
0.01645208,
-0.01789615,
0.0076135993,
-0.0021822213,
0.01508537,
-0.014221507,
0.0069173514,
0.0004931756,
-0.031356942,
-0.020655353,
-0.020913223,
-0.01827006,
-0.029216623,
0.011810427,
-0.014879075,
-0.009998893,
-0.001202317,
0.00030823474,
0.027308388,
0.009940872,
-0.0019823725,
0.031176433,
-0.028546162,
0.0117781935,
0.016942032,
-0.012822565,
0.0046932264,
-0.020242762,
-0.0026834554,
0.033780914,
0.00676263,
-0.009741023,
-0.0007450013,
0.02153211,
0.014866182,
0.0033265175,
-0.013383431,
0.015833192,
-0.00019622264,
-0.010849862,
0.01682599,
0.020397484,
-0.0031427855,
-0.011636365,
-0.017702747,
-0.0062920176,
0.01059844,
-0.020694034,
0.005927777,
-0.005370134,
0.015730044,
0.0070978603,
-0.021648152,
-0.004876958,
0.010347017,
0.0024610427,
0.00062896,
-0.017702747,
-0.014208614,
-0.02572249,
-0.010946563,
-0.013422112,
0.009715237,
-0.0007691766,
0.017844575,
0.031047497,
0.011275347,
-0.0087546725,
-0.017960615,
-0.023169583,
0.038603075,
-0.012745204,
-0.007323496,
0.0001787963,
0.011294687,
-0.010011787,
-0.015485068,
-0.030299677,
0.0065498874,
0.017780108,
-0.0010943341,
-0.00856127,
0.026367165,
0.00084613456,
0.018888947,
-0.0007421809,
-0.016542334,
-0.010604886,
-0.032336846,
-0.044044126,
0.015871873,
0.0042419545,
0.0032362633,
0.025361473,
-0.01874712,
-0.016323144,
-0.014376229,
0.011559004,
0.0068657775,
0.027849915,
-0.012571142,
-0.029397132,
0.010630674,
0.044895094,
-0.012268146,
0.00440957,
-0.010353464,
-0.011984489,
-0.0092768585,
-0.008812693,
-0.022447547,
0.024252634,
0.03231106,
0.002894586,
-0.040588673,
-0.0023337197,
0.01534324,
-0.0018453791,
-0.011655705,
0.0012361623,
0.035482854,
-0.009631429,
-0.035302345,
-0.0065079834,
0.005109041,
0.017032286,
0.018218486,
0.035302345,
-0.009309092,
0.018373208,
0.047112774,
0.042703204,
0.002465878,
0.0083034,
-0.024703905,
-0.023530599,
-0.00978615,
-0.01508537,
-0.018166913,
-0.0011620248,
-0.018128231,
-0.051857572,
-0.0035424833,
0.008844927,
0.001324805,
0.02864931,
0.011836214,
-0.02275699,
0.00056247803,
-0.008516143,
-0.016851777,
-0.04729328,
-0.03220791,
-0.004116243,
-0.0033490811,
-0.0068206503,
0.0010298666,
-0.026186656,
0.022808565,
-0.02534858,
-0.009077009,
0.0014489047,
-0.013963638,
0.00885782,
-0.028236719,
0.0061792,
0.0015786453,
0.000997633,
-0.008728885,
-0.0027543695,
0.014814608,
0.011023925,
0.006424176,
-0.0006523295,
-0.014053892,
0.0060212547,
-0.0074524307,
-0.012300379,
0.0051444983,
0.0056763543,
0.009257518,
0.035766512,
-0.016800202,
0.014298868,
0.037081644,
-0.0031653491,
0.005769832,
0.0058117355,
0.021983381,
0.010720928,
-0.02335009,
0.011243113,
0.008406549,
-0.0075620255,
0.024252634,
0.017277261,
-0.026844224,
0.0018195922,
-0.047267493,
-0.01237774,
-0.001621355,
-0.0111915395,
-0.014969329,
-0.006730396,
0.017986404,
0.0022273485,
-0.016129741,
-0.012777437,
0.00917371,
0.00796817,
0.023143794,
0.00950894,
0.01035991,
-0.026689501,
-0.013409218,
-0.008709545,
-0.007574919,
0.0357923,
-0.0058568628,
-0.00472546,
0.014505164,
-0.008077765,
0.019121028,
-0.005931,
-0.0037745659,
-0.014595418,
0.012061849,
0.010463058,
0.037236366,
0.006424176,
0.012764544,
-0.003278167,
-0.013015967,
0.025374366,
0.0012144046,
-0.018940521,
-0.0027334176,
-0.024523398,
-0.008058424,
0.013538153,
0.01949494,
0.03161481,
0.0043354323,
-0.012242358,
0.022022063,
-0.00384548,
0.018076658,
-0.0452819,
-0.009122136,
-0.018798692,
0.0024529845,
0.013783129,
0.027514685,
0.04933045,
0.018876053,
-0.000031855958,
-0.00074177794,
-0.0050510205,
0.016942032,
-0.008632184,
0.010172955,
-0.006601461,
0.007349283,
-0.028752457,
0.005354017,
-0.026741076,
0.0057440447,
0.019004988,
-0.009663663,
0.008471016,
-0.0010347017,
0.001274037,
0.024291314,
0.007626493,
0.007678067,
-0.026508993,
-0.0065079834,
0.0363854,
0.017277261,
-0.010334124,
-0.019224178,
-0.03669484,
0.00765228,
-0.013976531,
0.026895797,
-0.0013223875,
0.010192296,
0.0015762278,
0.027488897,
-0.012829011,
-0.016477866,
0.018025083,
-0.026637929,
0.019237071,
-0.002153211,
-0.006076052,
-0.018257167,
-0.007665173,
0.013003074,
0.058536395,
-0.0051702852,
-0.0055925464,
-0.018231379,
0.011217327,
-0.017096752,
-0.014711459,
0.0068399906,
-0.00086708646,
-0.00023772352,
-0.019482046,
0.008174466,
-0.0040678927,
-0.000027600103,
0.011081945,
-0.0026399398,
-0.0075362385,
-0.011990936,
0.0065660044,
-0.002781768,
0.028288294,
0.024768373,
0.009921532,
0.019843064,
0.0062114336,
0.009418687,
-0.015510855,
-0.043786254,
0.005956787,
-0.011475196,
-0.011275347,
-0.023736894,
0.028365653,
-0.008851374,
0.0036488546,
0.026289804,
0.01178464,
-0.0121714445,
0.009837724,
0.00019722994,
0.028752457,
0.013924957,
0.006859331,
0.023968978,
0.0062887943,
-0.0064435164,
0.011810427,
0.017148327,
0.01585898,
-0.018669758,
0.009476707,
0.019765703,
-0.009051222,
-0.0030605895,
-0.0148532875,
-0.034863967,
0.012609823,
0.007678067,
0.017135434,
0.021545004,
0.011017478,
0.022267038,
0.0123519525,
0.005163838,
0.0009533116,
-0.010372804,
0.0001386049,
0.00650476,
-0.022370186,
-0.01941758,
0.006366155,
-0.014543844,
0.009038329,
-0.03628225,
-0.009766811,
-0.023672428,
-0.01834742,
-0.01560111,
-0.022073636,
-0.023234049,
-0.019237071,
-0.021441856,
0.0126613965,
-0.017586706,
0.00028204484,
0.01745777,
0.00647575,
0.005424931,
-0.035044476,
-0.0021145307,
0.0017583482,
-0.03679799,
-0.012887033,
-0.0042580715,
0.01534324,
0.016503653,
0.012854799,
-0.014763033,
-0.00007438933,
0.018772906,
-0.027617833,
0.006101839,
0.009683003,
-0.04484352,
-0.052424885,
0.008825586,
0.01585898,
-0.02720524,
0.0069431383,
-0.02487152,
0.023285624,
0.003958298,
-0.0055313027,
-0.01593634,
-0.00678197,
0.020113828,
0.021003477,
0.03509605,
0.0044933776,
-0.024819948,
-0.012255251,
-0.026663715,
0.011127072,
-0.016632589,
0.009180157,
0.0052154125,
-0.029448707,
0.000941224,
-0.01971413,
-0.013499472,
0.015704257,
-0.018798692,
0.0049414258,
0.020590886,
0.0037681193,
0.011146412,
-0.011739513,
0.015420601,
0.011320475,
-0.016542334,
-0.0056118867,
-0.018141124,
0.02872667,
0.0076135993,
-0.029732363,
0.021080839,
-0.002884916,
-0.027566258,
0.004087233,
-0.002767263,
-0.015227199,
0.04865999,
0.010701587,
-0.041362282,
0.0068399906,
-0.010604886,
-0.026431631,
-0.0055570896,
0.00031750192,
-0.01872133,
-0.003033191,
0.019249965,
0.013886277,
0.009521835,
-0.02160947,
-0.027798342,
0.0026866787,
0.0049833297,
-0.006321028,
0.016258677,
-0.016361825,
-0.010353464,
-0.014827501,
0.014595418,
0.0014634099,
-0.039634556,
-0.008155125,
-0.02071982,
0.046081293,
0.03468346,
0.045720275,
-0.016890457,
0.0022998743,
0.026766863,
0.0064435164,
-0.0066336947,
-0.00012843114,
0.0032846138,
-0.017315943,
0.016800202,
0.03195004,
-0.005196072,
-0.005221859,
-0.017032286,
0.00013880635,
0.017960615,
-0.008774012,
-0.03035125,
-0.000900126,
-0.011797533,
-0.025387261,
0.009463813,
-0.01678731,
-0.019507833,
-0.013473686,
-0.021970488,
0.007800555,
-0.00018695544,
0.017380409,
-0.017315943,
0.03898988,
-0.01712254,
0.010753161,
-0.01678731,
0.011430069,
-0.010927224,
-0.0030106273,
-0.013170688,
-0.005547419,
0.03331675,
0.013512366,
0.012519568,
0.018785799,
0.005179955,
0.0099150855,
-0.001253085,
-0.023801362,
-0.0005431378,
-0.009863512,
-0.016722843,
0.0023063212,
-0.01949494,
-0.022782777,
-0.03754581,
-0.009799044,
0.024407355,
-0.0063887187,
0.009676556,
-0.014879075,
-0.023246942,
0.05544196,
-0.021841554,
0.0338067,
-0.020152507,
0.008000404,
0.024910202,
0.013486579,
0.0069882656,
-0.029293984,
-0.0037777894,
-0.004277412,
0.022473333,
0.019353112,
0.011197986,
0.009476707,
-0.019727023,
-0.004690003,
-0.013692874,
-0.035586003,
-0.0020065478,
-0.01538192,
0.0018647194,
0.0016423069,
0.01202317,
0.010450165,
0.0029010328,
-0.015962128,
-0.0023707885,
-0.013899171,
-0.0074653244,
-0.024587864,
0.025374366,
0.0012111812,
0.020810075,
-0.006614355,
-0.0073879636,
0.014930649,
-0.021983381,
-0.019301537,
-0.010269656,
0.0007764292,
0.025554875,
0.006614355,
0.0028091667,
-0.00022301689,
0.015033796,
-0.013538153,
0.0006096198,
-0.014595418,
0.038242057,
-0.010076254,
-0.0001695291,
0.00557643,
0.038938306,
-0.004087233,
-0.01931443,
0.007877916,
-0.014969329,
-0.021261347,
0.021300027,
0.011397836,
0.009186604,
0.0005294385,
-0.008168019,
-0.0062211035,
0.014337549,
-0.004332209,
-0.008741778,
0.022769883,
-0.05214123,
-0.013963638,
-0.004757694,
0.034760818,
0.016258677,
-0.01623289,
0.014169933,
0.0027366409,
0.021145305,
-0.028932966,
0.012635609,
0.02991287,
-0.020990584,
-0.0017422313,
0.0070978603,
-0.028107785,
-0.02264095,
0.019469153,
-0.019443367,
-0.014479377,
0.020023573,
-0.00018332916,
0.01615553,
0.0054700584,
-0.03450295,
0.01872133,
0.010102041,
-0.0026302696,
-0.0032797786,
-0.019559408,
0.019262858,
0.005437825,
0.016916245,
0.0042000506,
-0.011849107,
-0.0014593806,
0.0160137,
-0.026173763,
-0.01210053,
0.0037616724,
0.008335634,
-0.01538192,
0.010044021,
-0.02327273,
-0.009199497,
0.01678731,
-0.029448707,
-0.007600706,
0.007961723,
-0.00856127,
-0.007678067,
-0.03308467,
0.010791842,
0.015317453,
-0.0011168976,
-0.00943158,
-0.024007658,
0.023517706,
-0.009966659,
-0.020874543,
0.0014996728,
-0.01504669,
0.054049466,
0.0029413248,
-0.030119168,
-0.0020581216,
-0.018128231,
-0.06152768,
-0.006024478,
-0.0024481493,
0.010405038,
0.023698214,
-0.0069431383,
0.013422112,
0.009734577,
-0.015485068,
0.017290154,
-0.016697055,
-0.019623876,
0.014891968,
0.0072654756,
0.010463058,
-0.0015157897,
-0.044998243,
0.00008944851,
0.050671373,
-0.02001068,
-0.025064923,
0.017986404,
0.0016318309,
0.0049736598,
-0.0039679683,
-0.011243113,
0.0013054648,
0.028159358,
0.02631559,
-0.019133924,
-0.01239708,
0.021300027,
-0.0026866787,
-0.023930296,
-0.00012389828,
-0.014582525,
0.012854799,
-0.0054893987,
-0.0026689502,
-0.029216623,
-0.0024868299,
-0.014479377,
0.018398995,
0.022408867,
0.0121392105,
0.012010275,
0.009457367,
-0.023337197,
-0.02501335,
-0.0055957697,
-0.0247168,
-0.012758098,
0.023930296,
0.016774416,
-0.013834703,
0.0022531354,
-0.015188518,
-0.006398389,
-0.011604131,
-0.0010193906,
-0.010056914,
-0.00737507,
-0.005447495,
0.03076384,
-0.017225688,
0.006956032,
0.017367516,
-0.0089996485,
-0.005354017,
-0.010353464,
0.0092123905,
-0.011333368,
0.019378899,
-0.02034591,
-0.018914733,
-0.0068657775,
-0.0040743393,
0.0037810127,
-0.04365732,
0.02679265,
0.18515036,
-0.019675449,
0.008458123,
0.015291666,
-0.0034490055,
-0.0149177555,
-0.009973106,
-0.019649662,
-0.009180157,
-0.009940872,
-0.0039196177,
0.031099072,
-0.019482046,
-0.0035231432,
0.018463463,
-0.012203678,
-0.031666383,
0.020577993,
-0.015871873,
0.013989424,
-0.017058073,
-0.003478016,
-0.005379804,
0.0044998243,
0.015846085,
-0.0008276002,
-0.0314343,
0.0067690765,
0.0036649713,
0.0126613965,
-0.009251071,
-0.01941758,
0.0010943341,
0.0057923957,
0.009998893,
-0.005779502,
-0.0017889702,
0.0034844626,
0.004548175,
0.0029638885,
-0.0019662555,
0.007852129,
-0.00046134478,
-0.017728534,
-0.0039131707,
-0.015884766,
-0.019030776,
-0.019301537,
-0.018463463,
0.0012466382,
-0.029732363,
-0.0061792,
0.002393352,
0.03179532,
0.020835862,
-0.009380006,
-0.003600504,
0.011990936,
0.013899171,
0.014053892,
-0.012532461,
0.014324655,
-0.031356942,
0.0067432895,
-0.006259784,
0.035302345,
-0.012055403,
0.02975815,
0.024974668,
-0.02060378,
-0.010682248,
0.00032253843,
-0.007471771,
0.00950894,
-0.013551046,
0.0034296655,
0.018785799,
0.02064246,
0.016709948,
0.027282601,
-0.005067137,
0.00014021658,
-0.03602438,
0.014814608,
0.014943542,
-0.018992094,
0.020552205,
0.02386583,
0.002158046,
0.0016842107,
0.02220257,
-0.025890106,
-0.003125057,
-0.00022986655,
0.015549536,
-0.0004198439,
-0.012029616,
-0.0060212547,
-0.009973106,
-0.018218486,
-0.01115286,
0.065292574,
-0.004061446,
0.014775927,
-0.021622363,
-0.0068786712,
-0.016207103,
0.0014086126,
0.00036786706,
-0.017096752,
-0.0029896754,
-0.0035295899,
0.00943158,
-0.006827097,
0.0024513728,
0.0049285325,
0.01975281,
-0.044379354,
0.03862886,
-0.013183583,
-0.004470814,
-0.007523345,
-0.0056763543,
0.00970879,
-0.010095594,
0.013254496,
-0.0056441203,
-0.0017776884,
-0.008490356,
-0.04543662,
0.0054990686,
0.00950894,
0.004280635,
-0.007175221,
0.0100827,
-0.014995116,
0.006898011,
-0.0062372205,
-0.010714481,
0.019559408,
-0.011629918,
0.0013425335,
-0.0053733573,
-0.0011733066,
-0.0032894488,
-0.0073170494,
0.023169583,
0.014763033,
-0.006137296,
0.0006982625,
-0.0033232942,
-0.014685673,
0.0029574418,
0.0004444221,
0.005395921,
-0.020926116,
-0.028984541,
-0.01890184,
-0.016091062,
-0.00015411737,
-0.0357923,
-0.0028913626,
0.038242057,
-0.013460792,
-0.0013699322,
0.01415704,
-0.15987913,
-0.0016954925,
0.003687535,
-0.032697864,
0.053894743,
0.014543844,
0.017174114,
-0.00019269707,
0.0020194412,
0.0074266437,
0.008168019,
0.0067432895,
-0.053688448,
-0.035766512,
-0.009850618,
0.011900681,
-0.013035308,
-0.0012216571,
0.035173412,
0.008535483,
0.021416068,
-0.049536746,
0.0013207757,
-0.0011088392,
0.020810075,
0.033884063,
0.0007969782,
-0.011030371,
-0.0044160164,
-0.0020468398,
-0.021042157,
0.024691012,
0.02064246,
-0.021209773,
0.013164242,
0.013628407,
-0.0013626795,
0.0052444227,
0.0047899275,
0.009683003,
0.013157795,
0.010218082,
0.020874543,
-0.0049736598,
0.0059148837,
0.005876203,
0.0115009835,
-0.006395166,
0.023530599,
0.0043999,
0.005421708,
0.0026254347,
-0.00044845132,
0.008587057,
0.019030776,
0.00071276765,
-0.006101839,
0.030866988,
-0.0037745659,
0.017019393,
-0.0022031732,
-0.010708034,
0.060960367,
-0.019262858,
0.0071816677,
-0.020384591,
-0.01615553,
0.008696652,
-0.011629918,
0.0010322841,
0.0034038785,
-0.012584035,
0.002301486,
-0.011397836,
0.004219391,
0.0114365155,
-0.025877213,
0.000052933774,
-0.011462303,
0.0064273993,
0.009438027,
0.018643972,
-0.00052863266,
-0.016477866,
-0.018966308,
-0.018102445,
-0.007323496,
0.012487334,
-0.02645742,
-0.0055925464,
0.026135081,
-0.012725864,
-0.010791842,
0.008677311,
0.020990584,
0.020797182,
-0.013692874,
-0.00013487788,
-0.016181316,
0.0023707885,
0.017174114,
-0.017328836,
-0.0033716448,
0.02356928,
0.040227655,
0.008071318,
0.00530889,
-0.0028107783,
0.056318715,
0.013080435,
-0.011455856,
-0.0026367165,
0.007504005,
0.039789278,
-0.021699725,
0.02619955,
-0.0071881143,
0.004741577,
-0.00414203,
-0.004306422,
0.070346825,
0.025232539,
-0.00280272,
0.009205944,
-0.009734577,
-0.01945626,
-0.1283159,
-0.0069753723,
-0.016142637,
0.029526066,
0.006659482,
0.020294337,
-0.0044192397,
0.03365198,
-0.0023869053,
0.009251071,
-0.000037799047,
-0.0117781935,
-0.009547621,
-0.009463813,
0.0017003275,
0.0217513,
-0.0025867543,
-0.01627157,
-0.020062253,
0.012848352,
-0.0050800308,
0.022176784,
-0.023440344,
0.014891968,
0.010456611,
-0.023801362,
-0.018502142,
0.02487152,
0.025077816,
-0.00084532873,
-0.0023691768,
-0.019237071,
0.009663663,
-0.00043998996,
0.0029542183,
-0.003810023,
-0.01708386,
-0.026741076,
0.042264823,
-0.0043515493,
-0.00080946874,
-0.011081945,
-0.0039099474,
-0.011423622,
0.019288644,
0.0016761522,
-0.0021612693,
0.0036681949,
0.001677764,
0.01210053,
-0.019391792,
-0.029964445,
-0.04569449,
-0.02064246,
0.023298517,
0.0025561322,
-0.016671268,
-0.0007808613,
-0.0083614215,
0.010843416,
-0.00019702848,
-0.008774012,
-0.003977638,
0.00037250065,
0.009077009,
-0.012635609,
0.0017003275,
-0.031821106,
0.013254496,
-0.051496554,
0.015265879,
0.001242609,
-0.011842661,
0.005189625,
-0.027256815,
-0.0022950394,
-0.046081293,
-0.030970136,
0.006807757,
-0.0075362385,
-0.006736843,
-0.03171796,
0.016477866,
-0.018927626,
0.004628759,
0.028468803,
0.02327273,
-0.017367516,
0.030377036,
-0.013486579,
0.015781619,
0.028623523,
0.02090033,
-0.005479729,
0.01035991,
0.022292824,
-0.02097769,
-0.012667843,
0.010011787,
-0.0014279528,
-0.03220791,
-0.009908639,
-0.05273433,
0.032646287,
0.017780108,
-0.016761523,
0.016619695,
-0.007645833,
-0.0055280793,
-0.0034232186,
0.022550695,
0.03806155,
-0.028752457,
-0.0035231432,
0.019340219,
-0.003170184,
-0.030738054,
0.011030371,
0.028520375,
-0.0009468649,
0.02404634,
0.011094838,
-0.023943191,
-0.0069689252,
0.008077765,
0.04043395,
-0.026741076,
-0.01571715,
-0.008954521,
-0.0059342235,
-0.006230774,
-0.0030912117,
-0.0011225385,
-0.02687001,
-0.013460792,
0.017780108,
-0.014556738,
-0.029861297,
-0.01986885,
0.030041806,
0.026251122,
0.04079497,
-0.008554824,
-0.048866287,
0.0064209527,
-0.002588366,
-0.016323144,
-0.020023573,
-0.036565907,
0.00090093183,
-0.0137573425,
0.005186402,
0.010940117,
-0.0023949638,
-0.006408059,
0.005598993,
-0.014118359,
0.010437272,
-0.009018988,
0.002706019,
0.008438782,
-0.012764544,
0.011288241,
0.020088041,
-0.0024836063,
-0.008774012,
-0.0022982627,
0.0012845128,
-0.016581014,
-0.021557897,
-0.023466133,
-0.013538153,
-0.017522238,
0.042006955,
0.019172603,
0.014982223,
-0.0033265175,
0.012145657,
-0.024110805,
0.017328836,
-0.0032862255,
0.0043805595,
0.009618536,
0.0137573425,
-0.013177136,
0.01686467,
0.024420248,
0.004996223,
0.030196527,
0.023130901,
-0.027978849,
-0.013183583,
0.0015858979,
0.01704518,
0.001979149,
0.015871873,
0.018785799,
0.026341377,
-0.01445359,
0.0026383281,
0.0049414258,
0.01123022,
0.0031685724,
-0.013641301,
0.000049785955,
-0.01704518,
-0.0008622514,
0.00440957,
-0.02991287,
-0.053430576,
-0.013318964,
-0.007852129,
-0.010424377,
0.0068206503,
0.021996275,
-0.00412269,
0.007955276,
-0.0002699572,
-0.0041517,
-0.024484716,
0.013112668,
0.02687001,
0.014840394,
0.03409036,
0.015510855,
0.001202317,
0.014659885,
-0.001222463,
0.0064209527,
-0.034374014,
0.026122188,
-0.0059084366,
0.005447495,
-0.017702747,
-0.00915437,
-0.020229869,
-0.002981617,
-0.0006225133,
0.009895745,
0.018579504,
-0.004251625,
0.07643254,
0.011088392,
-0.014518057,
0.018102445,
-0.019959105,
0.03669484,
0.01356394,
0.011617024,
-0.009057669,
-0.032336846,
0.042703204,
0.0040324354,
0.029835511,
-0.020281443,
-0.006898011,
0.0034747927,
0.0004955931,
0.031073285,
-0.023234049,
-0.010753161,
0.020436164,
-0.018411888,
0.0024320325,
0.015987914,
-0.04069182,
0.01182332,
0.034477163,
-0.004496601,
0.02957764,
-0.04814425,
-0.0025577438,
-0.015652683,
-0.020745607,
0.0008380761,
0.013447898,
-0.00798751,
-0.009296198,
-0.0007010829,
0.006756183,
0.00176963,
0.009528281,
-0.0069882656,
-0.011829767,
-0.011610578,
0.014169933,
0.0009936037,
0.0036230676,
0.017187007,
-0.013254496
] |
The identification of brain tumor stem-like cells (BTSCs) has implicated a role of biological self-renewal mechanisms in clinical brain tumor initiation and propagation. The molecular mechanisms underlying the tumor-forming capacity of BTSCs, however, remain unknown. Here, we have generated molecular signatures of glioblastoma multiforme (GBM) using gene expression profiles of BTSCs and have identified both Sonic Hedgehog (SHH) signaling-dependent and -independent BTSCs and their respective glioblastoma surgical specimens. BTSC proliferation could be abrogated in a pathway-dependent fashion in vitro and in an intrac | [
-0.011657966,
-0.009390215,
-0.0006924619,
-0.030830765,
-0.020416403,
-0.009104253,
-0.013194184,
0.012176689,
-0.030750962,
-0.008432574,
0.030218938,
0.0024273575,
0.004651881,
-0.0058156825,
-0.004385869,
0.010913134,
0.02758542,
0.001887021,
-0.0052470826,
0.03205442,
-0.018461218,
0.007933801,
0.009496621,
-0.015641492,
0.016000608,
-0.0007381827,
0.013978919,
-0.041843653,
-0.0069429073,
-0.014045422,
0.010906483,
0.002959381,
-0.035778586,
0.0089113945,
-0.0058156825,
-0.022903614,
0.011997132,
-0.010141699,
0.010155,
-0.0016592485,
-0.014870059,
0.021573555,
0.0041231825,
-0.011006237,
-0.0110793905,
-0.014657249,
-0.013174233,
-0.012934823,
-0.006055093,
0.01649273,
0.0012494241,
-0.001263556,
-0.028543064,
0.013014627,
-0.027053397,
0.0041664094,
0.019152848,
0.027984438,
0.0138725145,
-0.018580923,
0.014936562,
-0.0138725145,
-0.016426228,
0.007973703,
0.020576011,
0.00994219,
-0.017995697,
0.011312151,
0.008299568,
-0.006450786,
0.019325756,
0.0059653143,
-0.011199096,
-0.019591767,
0.0146439485,
-0.0248189,
-0.017423771,
-0.017596679,
-0.013406994,
0.0035545824,
0.0025370873,
-0.01625332,
-0.004202986,
0.021999175,
0.0158144,
0.00531026,
-0.021959273,
0.013021276,
-0.0018936713,
-0.0010765165,
0.018155305,
0.015388781,
-0.008858192,
0.010893182,
-0.00059894216,
0.012096886,
-0.018567622,
0.024060765,
-0.0011172495,
-0.034953948,
-0.009862387,
0.009303762,
0.00066793896,
-0.02598935,
-0.02912829,
0.00010837902,
0.017649882,
0.016585834,
0.013001326,
-0.013739509,
-0.009117554,
0.022916915,
-0.03234703,
-0.030165736,
0.016373025,
0.012209941,
0.0146439485,
0.004060005,
-0.015109469,
0.008006955,
0.030192336,
-0.014963162,
0.008312868,
-0.01897994,
0.015920805,
0.025031708,
-0.020748919,
0.0012203291,
-0.011657966,
-0.004538826,
0.004914568,
0.0067367484,
-0.0024389955,
0.015601591,
-0.029287897,
-0.013047878,
-0.00418636,
-0.005300285,
-0.014816856,
-0.02056271,
-0.002921142,
0.0383855,
-0.0063743074,
-0.0031888161,
0.0068697543,
0.014776954,
0.029766718,
0.013267337,
0.01220329,
0.010647122,
-0.0039536,
-0.018554322,
0.016146915,
-0.008791689,
0.002869602,
-0.00462528,
0.019112946,
0.045966834,
-0.01376611,
0.0043260166,
0.004831439,
-0.005396714,
0.028330255,
0.0010623846,
0.019299155,
0.026747484,
-0.010607219,
0.01625332,
0.013167583,
-0.011265599,
0.0047549605,
0.034421925,
-0.035140157,
-0.0029660314,
-0.026268663,
0.0021995849,
-0.003310184,
0.011318801,
-0.018381413,
-0.03178841,
-0.021360746,
0.01287497,
0.014750353,
0.008492426,
-0.01379271,
-0.010494165,
0.025723338,
-0.01379271,
0.01333384,
-0.024566188,
-0.001996751,
0.0056527504,
-0.0016060461,
-0.004808163,
-0.63204396,
-0.032613043,
0.009330363,
-0.0061049704,
0.020270098,
0.033145066,
0.0003915361,
-0.013533349,
-0.036656424,
0.0042129615,
-0.01897994,
0.007202269,
0.003454828,
-0.012249842,
-0.012921522,
-0.026295265,
-0.012555756,
-0.0025853019,
0.02666768,
-0.0029809945,
-0.007893899,
0.00074649556,
0.0032486687,
0.032879055,
0.003996827,
0.027372612,
0.03636381,
-0.009869037,
-0.0044423966,
0.028383456,
-0.028303653,
0.021214439,
0.0058755353,
-0.0022943516,
0.044636775,
0.006487362,
-0.00903775,
0.031203182,
0.0009202345,
0.022105578,
0.0018288309,
-0.013373742,
0.03907713,
0.008259666,
-0.04043379,
0.028303653,
-0.005918762,
-0.0041231825,
-0.020203594,
-0.016506031,
0.011431856,
0.014258231,
-0.010520766,
0.0030325344,
0.026468173,
0.0015029665,
0.024087366,
-0.027425814,
0.0025819768,
-0.023103124,
0.001124731,
0.02641497,
-0.0038538456,
-0.010354509,
0.017290765,
0.025444027,
-0.028330255,
-0.014138526,
0.01240945,
-0.0071224654,
0.008505726,
0.03250664,
-0.01310108,
0.012642209,
0.01106609,
0.037161846,
-0.013021276,
0.003014246,
0.021719862,
-0.009337014,
0.011438507,
-0.011365353,
-0.0293943,
-0.0068498035,
0.021879468,
-0.026242062,
-0.0025603634,
0.007069263,
-0.0024456459,
0.0155483885,
0.004738335,
0.005805707,
-0.015282377,
-0.052537326,
0.011897377,
0.011431856,
-0.0019252603,
0.014776954,
0.015455284,
-0.029766718,
-0.03947615,
-0.0035346316,
0.023688348,
0.016532632,
0.009277161,
0.018634126,
-0.027878035,
-0.014843457,
0.029181492,
-0.02304992,
0.0060417927,
0.023089822,
0.0067201224,
-0.0040101274,
-0.0063643316,
-0.023475539,
0.021546954,
0.014032122,
-0.0020167017,
-0.034022905,
0.0027964488,
0.004046704,
0.003614435,
-0.001475534,
0.03117658,
0.00047050833,
0.019139547,
-0.005360137,
0.00023068208,
-0.012608958,
-0.014883359,
-0.031815007,
0.018341511,
-0.033065263,
0.03567218,
0.0017556777,
0.0023076523,
-0.005852259,
0.011990481,
-0.023382435,
-0.035086952,
-0.01691835,
0.0052271313,
-0.0014622335,
-0.019658271,
-0.005190555,
-0.015056266,
-0.007947102,
0.01697155,
-0.0033567362,
0.012914872,
-0.0010457588,
-0.0031372765,
0.0062379763,
0.018461218,
-0.015920805,
-0.013240736,
-0.016758742,
0.023648446,
-0.0146439485,
-0.005054224,
0.025922848,
-0.0015553376,
-0.0046585314,
-0.028995285,
-0.02412727,
-0.01649273,
0.0064474605,
0.0121301375,
-0.041019015,
-0.0056294743,
-0.024965206,
0.0023375785,
0.007860648,
-0.013726207,
-0.007361876,
-0.007767544,
-0.005902136,
0.0006837334,
-0.0074948817,
-0.011817574,
-0.0000574627,
0.0147104515,
-0.016998153,
0.036683023,
0.021094734,
0.024100667,
0.001281013,
0.0055263946,
-0.002448971,
-0.012569057,
0.028064243,
-0.0090444,
0.017024754,
-0.0017141134,
-0.015322278,
0.00925056,
-0.008485775,
-0.0026069155,
0.01694495,
0.020403104,
-0.0068697543,
0.030245539,
-0.023382435,
0.025896247,
-0.022637602,
-0.0064108837,
-0.026268663,
-0.0014331385,
0.00012251089,
-0.0016068774,
0.0040533543,
-0.0062845284,
-0.0016875123,
-0.013526699,
0.00095016084,
-0.005213831,
-0.020243496,
0.004066655,
-0.01985778,
-0.0063344054,
-0.0051839044,
-0.01469715,
-0.020057289,
-0.0028679394,
0.038545106,
-0.0010532404,
0.006896355,
-0.002304327,
-0.004715059,
0.006500663,
0.03745446,
0.02008389,
0.0073685264,
0.016346423,
0.004671832,
0.019511964,
0.0002786889,
0.04474318,
-0.0029460804,
-0.0036842632,
0.017809488,
-0.010580619,
-0.0013890803,
0.011092691,
0.003817269,
0.035193358,
-0.006354356,
-0.0068631037,
0.017995697,
-0.03498055,
0.0013067828,
-0.012562406,
-0.007135766,
0.041178625,
-0.019232651,
0.0051174015,
0.0032054419,
0.020576011,
0.0069894595,
0.00926386,
0.008339469,
0.007727642,
-0.016439527,
0.0053867386,
0.01197053,
0.02303662,
0.002803099,
-0.0073685264,
-0.009888988,
-0.01872723,
-0.0011147556,
-0.0011538261,
-0.036337208,
0.008937996,
0.014763653,
0.020216895,
0.025430726,
-0.010540716,
0.015468585,
-0.015654793,
-0.022730706,
0.009968791,
0.03114998,
-0.022557799,
-0.013619803,
-0.016306521,
-0.018580923,
-0.0017689783,
-0.00094267924,
0.008006955,
0.011318801,
0.0004559608,
0.014816856,
-0.019405559,
-0.0180755,
-0.010740225,
0.0071956185,
0.0049611195,
-0.007082564,
0.014737053,
0.0025320996,
-0.015495186,
0.00040691489,
0.014737053,
0.014111925,
-0.024113968,
-0.0062013995,
-0.016625736,
-0.012941473,
0.0012361235,
-0.021307543,
-0.004994371,
-0.0083195185,
0.0361776,
0.0054598916,
0.028596267,
0.0058821854,
0.016306521,
0.02461939,
-0.015641492,
-0.02665438,
-0.018434616,
-0.008405972,
0.03500715,
0.032373633,
-0.017184362,
-0.0028862278,
0.0030308717,
-0.00003465427,
-0.017277464,
-0.020576011,
0.011345402,
-0.036762826,
0.004562102,
0.0070094103,
-0.0024805597,
0.008033556,
-0.0005661063,
0.033038665,
-0.009177406,
-0.0005465711,
-0.00021800496,
-0.021307543,
-0.009084302,
-0.010653771,
0.019299155,
0.049371786,
0.014431139,
-0.0069296067,
-0.0005798226,
0.008020255,
-0.0019352357,
-0.0048912917,
-0.031282984,
0.010746876,
-0.016333124,
0.0070094103,
0.012675461,
-0.019485364,
0.013293939,
0.017995697,
-0.010806728,
0.0027864734,
0.033038665,
-0.0008553941,
0.018381413,
-0.0059919152,
0.010866581,
-0.022504596,
0.003770717,
-0.001118912,
-0.0037873427,
-0.022384891,
0.02374155,
-0.016439527,
-0.0063876077,
-0.008445874,
0.016758742,
-0.00666692,
-0.0019834503,
-0.006730098,
0.01468385,
-0.0053834133,
-0.008272966,
-0.045727424,
0.025789842,
0.0006030986,
0.00462528,
-0.00051290396,
-0.013147633,
-0.007587986,
-0.025138114,
-0.0033866626,
0.009842436,
-0.010926434,
-0.05937383,
0.011352053,
0.01735727,
0.016107013,
0.010627171,
-0.0060683936,
-0.02621546,
0.029766718,
-0.012389499,
-0.021334145,
-0.009337014,
-0.016293222,
0.026109057,
0.007208919,
0.0027981114,
-0.007415078,
-0.0057225786,
0.0036011345,
0.021214439,
-0.0067367484,
0.009097603,
0.00009913095,
0.0066735707,
0.0055862474,
0.028037641,
-0.0024772347,
-0.0017457023,
0.0013375405,
0.00062138686,
-0.03133619,
-0.014484341,
-0.009596375,
0.0002029379,
-0.015907504,
0.005463217,
-0.00023691673,
-0.011398605,
-0.011039489,
0.015415383,
-0.006051768,
0.01874053,
-0.008459175,
0.010560668,
-0.003321822,
-0.004831439,
-0.0069163064,
-0.0017689783,
0.013992219,
0.017969096,
-0.020469606,
0.038731314,
-0.00598194,
-0.029633712,
0.0010948047,
0.023980962,
-0.004016778,
-0.031123377,
-0.02555043,
0.0040932563,
0.038092885,
-0.012043683,
-0.0054000393,
-0.019777976,
-0.01558829,
-0.015960706,
0.017011452,
-0.001518761,
-0.014058722,
-0.015867602,
0.027984438,
-0.0024423206,
-0.00631778,
0.00812001,
-0.03585839,
-0.008711886,
0.016811945,
0.026109057,
0.008698585,
-0.016545933,
0.011691217,
-0.01987108,
-0.028383456,
-0.007388477,
-0.042535283,
-0.0029460804,
-0.012023732,
0.034741137,
0.0293411,
0.030139135,
0.008971247,
0.019777976,
0.044211157,
0.007933801,
0.0017922544,
-0.0028762524,
0.019405559,
-0.0180755,
0.013247387,
-0.015016365,
-0.0053867386,
0.015175972,
0.006793276,
0.0125092035,
0.040327385,
-0.0044590225,
-0.002834688,
0.008166562,
-0.05083485,
-0.035565775,
-0.00058522593,
-0.00036368798,
0.014550844,
-0.034741137,
-0.0070559625,
0.036017995,
0.018793732,
-0.005968639,
0.018886836,
0.01760998,
-0.009509921,
0.021879468,
0.0008383528,
-0.00065921043,
-0.01671884,
-0.018035598,
-0.0040965816,
-0.037215047,
0.0052736835,
0.0043925196,
-0.0038039684,
0.022783909,
-0.031256385,
0.00025187992,
0.0069229566,
-0.042349074,
-0.013633104,
-0.0041697347,
-0.017809488,
-0.018580923,
-0.012083585,
-0.03412931,
-0.010148349,
-0.021360746,
-0.014524243,
-0.012881621,
0.012682112,
-0.007428379,
-0.009975442,
0.04766931,
-0.008758438,
0.030085932,
-0.003926999,
0.016067112,
0.013273988,
0.010766827,
-0.0074483296,
-0.010414361,
-0.0067633493,
-0.0010158325,
0.02686719,
0.023502141,
-0.013573251,
-0.022890314,
0.015136071,
0.026388368,
-0.019352358,
-0.028064243,
0.017064655,
0.009496621,
0.0014131876,
-0.008598831,
-0.019112946,
-0.03572538,
0.016120315,
0.006191424,
-0.0016010584,
-0.0012544118,
-0.01827501,
-0.013433595,
0.028489862,
-0.0039369743,
0.014537544,
-0.022331689,
0.012715363,
-0.014391237,
-0.0036277357,
-0.025909547,
-0.0077076913,
-0.009356964,
0.025337622,
-0.03793328,
-0.00016552999,
0.03540617,
-0.0032586444,
-0.012276444,
-0.007335275,
0.022398192,
0.042242672,
-0.014085324,
-0.00259694,
0.0072820727,
-0.0066735707,
0.014524243,
0.0031006997,
0.0022677504,
-0.0030973747,
-0.021081433,
-0.016080411,
0.036443613,
0.0338633,
0.005270358,
0.004472323,
-0.022078978,
-0.021360746,
-0.01735727,
-0.010540716,
0.00745498,
-0.043333318,
0.002912829,
0.022092279,
0.028782474,
0.03319827,
0.0019684872,
-0.0035978092,
0.0036443614,
0.044317562,
-0.006407559,
0.006530589,
0.017969096,
0.016226718,
-0.027239606,
-0.0047782366,
0.021586856,
-0.04381214,
0.011498359,
-0.022305088,
-0.008519027,
-0.012209941,
0.0041231825,
0.022557799,
-0.00993554,
-0.017476974,
0.009822485,
0.009383566,
0.018447917,
-0.013633104,
-0.015907504,
0.005533045,
-0.015189272,
-0.010760176,
-0.013127681,
-0.015056266,
-0.004788212,
0.013426945,
0.0041697347,
0.0012419425,
-0.0069429073,
-0.0039602504,
-0.0059553385,
-0.0073020235,
-0.012981375,
0.015255775,
0.0019252603,
-0.018807033,
-0.019046443,
-0.010906483,
-0.016905049,
-0.004991046,
-0.026933692,
0.005336861,
0.006011866,
0.008033556,
-0.023648446,
0.0037840176,
-0.016905049,
-0.028968683,
-0.03521996,
0.014218329,
-0.03774707,
0.026547976,
0.011824223,
-0.0069030058,
-0.02100163,
-0.014737053,
-0.04157764,
-0.021759763,
0.02819725,
0.012901572,
-0.00115632,
0.0080734575,
-0.024645992,
-0.006184774,
-0.0048414143,
0.008159911,
0.021493752,
-0.01534888,
0.03883772,
0.00059603265,
0.008798339,
0.006956208,
-0.0248322,
-0.020004086,
0.013586552,
-0.010194901,
-0.0074882316,
0.0052537327,
-0.016107013,
0.027399214,
0.014564145,
0.014630647,
0.0035878338,
0.03253324,
-0.009775933,
-0.015614891,
0.012495903,
0.0007602118,
-0.00074524863,
-0.0029776692,
0.003060798,
0.0055696215,
0.010886532,
0.0037208397,
-0.013526699,
-0.020802122,
0.012761915,
0.005672701,
0.03498055,
0.013726207,
0.05442601,
0.014737053,
0.0011164182,
-0.0030441722,
-0.008918045,
-0.0048447396,
0.0014389575,
-0.007162367,
-0.00071199716,
-0.024699194,
-0.014417838,
-0.0036709625,
0.009755982,
-0.02688049,
0.009975442,
-0.005439941,
-0.008179862,
-0.040753003,
0.03224063,
0.005217156,
-0.032559842,
-0.024752395,
-0.0022511247,
-0.010939734,
-0.021653358,
-0.014524243,
0.010241454,
-0.017769586,
0.023382435,
-0.0112922,
0.005150653,
0.004089931,
-0.0059919152,
0.011019538,
-0.015402082,
-0.010274705,
0.18716589,
-0.028064243,
-0.0016368037,
0.00053784257,
0.0072554713,
-0.012775215,
0.019817878,
0.003115663,
0.0032220676,
-0.004535501,
0.004668507,
0.004661856,
-0.007933801,
-0.0048580403,
0.020961728,
-0.014577446,
-0.013433595,
-0.02098833,
-0.02053611,
-0.024459783,
-0.005190555,
-0.013347141,
0.0015279051,
-0.0029793319,
0.017543476,
-0.0036410363,
-0.017729685,
0.005014322,
0.032772653,
-0.0015977332,
-0.029926324,
0.016452828,
-0.018447917,
0.0019751375,
0.018354813,
0.0018271684,
-0.0034032883,
-0.014085324,
0.008366071,
0.014072023,
-0.013200834,
0.022105578,
-0.0063610068,
0.005010997,
-0.00835277,
0.03178841,
-0.009084302,
0.00428944,
0.020270098,
0.014976463,
-0.05799057,
0.018487819,
0.020868624,
0.015641492,
-0.0009958816,
-0.007361876,
0.012928172,
0.020469606,
-0.010454263,
0.024034165,
-0.025364224,
0.017051356,
-0.037348054,
0.021041531,
0.008199813,
0.021267641,
-0.0054898183,
0.02142725,
0.019525265,
-0.008000304,
0.0034481776,
0.002182959,
-0.01760998,
0.009895639,
-0.023196228,
-0.020961728,
0.038811117,
-0.020070588,
0.017304067,
0.026135657,
0.004648556,
0.0066935215,
-0.0138060115,
-0.006444135,
0.0018969965,
-0.02461939,
0.018647425,
0.015628193,
-0.0031239758,
-0.007248821,
0.012642209,
0.006510638,
0.001817193,
-0.0069229566,
-0.0006234651,
0.001965162,
0.014484341,
0.01760998,
0.011345402,
-0.006124921,
-0.03476774,
0.056873318,
0.036284007,
0.005336861,
0.0043160412,
0.0013375405,
-0.0027465716,
-0.0069163064,
-0.009829136,
-0.0028446636,
0.004365918,
-0.0248588,
0.014870059,
-0.0018620824,
-0.0011031176,
0.015561689,
-0.00023878714,
-0.0074416795,
0.051526483,
-0.016186817,
0.005336861,
-0.023448939,
-0.013174233,
0.041231826,
-0.03657662,
0.015295677,
-0.0149897635,
-0.0083860215,
-0.013739509,
-0.009922239,
-0.028729273,
-0.0055862474,
-0.005014322,
0.006168148,
0.01693165,
-0.004495599,
0.0030508225,
-0.00050375983,
-0.043891944,
0.016093712,
-0.0078007956,
-0.0042196116,
-0.032426834,
0.024459783,
0.01896664,
-0.041657444,
0.015521787,
0.022211984,
-0.00745498,
-0.016838545,
0.0023475538,
-0.015694695,
-0.020403104,
0.0025454003,
0.011498359,
-0.019977484,
-0.015960706,
-0.030671159,
-0.012316345,
0.032214027,
-0.0338367,
0.022251885,
-0.0022561124,
-0.0116380155,
-0.004000152,
0.004216287,
-0.16694899,
-0.0034415275,
0.03865151,
-0.022477996,
0.025430726,
0.0155483885,
0.0009293787,
-0.0077808443,
-0.0032619694,
0.021174537,
0.05213831,
0.01534888,
-0.046392456,
-0.01715776,
0.008652033,
-0.005469867,
0.008213114,
0.061767936,
0.012402799,
0.013939017,
0.009762633,
-0.023994263,
0.01332719,
-0.006816552,
0.006962858,
-0.024207072,
-0.012954773,
-0.019019842,
-0.009077652,
0.0030491601,
-0.011179145,
0.010327907,
0.0092239585,
-0.016732141,
0.0225711,
0.0111126425,
-0.017277464,
0.0028878904,
-0.010214852,
0.016572533,
0.00813331,
0.025882946,
0.007361876,
-0.0047316845,
0.001405706,
0.029500706,
0.0017207637,
-0.003005933,
0.01872723,
-0.012143438,
0.020895226,
-0.0018321561,
-0.0070759133,
0.02097503,
0.015229174,
0.022291787,
0.015149371,
0.0158144,
-0.0008819953,
-0.018700628,
-0.004871341,
-0.018860236,
0.0111458935,
-0.00992889,
-0.014843457,
-0.038039684,
-0.0027066697,
-0.02758542,
-0.038970727,
0.0062712277,
-0.025856344,
-0.0059054615,
0.010194901,
-0.033703692,
0.021985874,
0.015428683,
0.0077608936,
0.017796189,
-0.0091574555,
0.0053634625,
0.00022299269,
0.014896659,
-0.019126248,
-0.019099645,
0.0033500858,
0.002402419,
0.0029959576,
0.018793732,
-0.0062645776,
-0.0010790103,
0.013134331,
-0.012562406,
-0.0074217287,
-0.01445774,
0.0041830353,
0.015947405,
-0.014484341,
-0.013127681,
0.013486797,
0.0022394867,
0.02685389,
-0.0052537327,
-0.017596679,
0.023635147,
0.026348466,
0.0068032513,
-0.010181601,
0.027319409,
0.032772653,
-0.012761915,
-0.009290461,
-0.0101683,
0.0037574163,
0.009237259,
0.00088282657,
0.04043379,
-0.020456307,
0.0023542042,
0.009017799,
-0.015841002,
0.07565375,
-0.0030624606,
-0.01128555,
0.014524243,
0.007016061,
-0.0060916697,
-0.12800486,
-0.027957838,
-0.008838241,
0.010002043,
-0.021852868,
0.009829136,
-0.011664617,
-0.0016791994,
-0.016346423,
0.029234694,
-0.018115401,
-0.033597287,
-0.017969096,
-0.024193771,
0.0129680745,
-0.014338035,
0.015668094,
0.007474931,
-0.017703084,
0.033969704,
0.0015811075,
-0.0033667115,
-0.020230196,
-0.018620824,
0.010786777,
0.016426228,
-0.04875996,
0.022305088,
0.0057059526,
0.0180489,
-0.0013375405,
-0.006976159,
0.017184362,
0.007927151,
-0.0032353683,
-0.00077517494,
0.005080825,
-0.038917523,
0.025577033,
0.0015694695,
-0.0066037425,
0.017224263,
0.042083062,
0.017915893,
0.0024439832,
-0.020842023,
-0.025390824,
0.0060650688,
0.027479017,
-0.024047464,
-0.026574576,
-0.01916615,
-0.013433595,
-0.00080925773,
0.008844892,
-0.012289744,
0.011099341,
0.032001216,
-0.016639037,
0.010673722,
-0.002304327,
-0.0017407145,
-0.027239606,
0.009549823,
0.011804272,
0.006836503,
-0.038571708,
-0.03293226,
0.01741047,
-0.019352358,
0.0059919152,
-0.00025915366,
-0.006553865,
-0.017596679,
-0.035592377,
-0.013027927,
0.019738074,
-0.027745029,
0.00925056,
-0.03548597,
-0.013413644,
-0.012336296,
0.014324734,
-0.018434616,
0.017543476,
-0.0146439485,
0.0035745334,
-0.008452524,
0.003907048,
-0.024938604,
0.029553909,
0.032852456,
-0.02577654,
-0.039688956,
-0.002402419,
0.0076411883,
-0.009529872,
0.02527112,
0.027026797,
0.017756287,
-0.007840697,
-0.016067112,
-0.061076306,
0.025164714,
-0.00067749876,
-0.003481429,
0.021493752,
-0.00074815814,
0.020482907,
-0.0095032705,
-0.008425923,
0.00620805,
0.009742682,
0.008605481,
-0.005300285,
-0.0012120162,
-0.02076222,
-0.036204204,
0.029926324,
-0.03274605,
0.011179145,
0.026561277,
0.012914872,
-0.010241454,
0.01828831,
0.009064351,
-0.02008389,
-0.009496621,
-0.009682829,
0.044849586,
-0.019910982,
-0.014776954,
-0.010740225,
-0.04226927,
-0.0017656531,
-0.0077143414,
-0.008405972,
-0.014723752,
0.021280942,
0.027824832,
0.018554322,
0.035352964,
-0.021719862,
-0.02822385,
0.0088781435,
0.013859213,
0.0025853019,
0.0033051963,
-0.035938192,
-0.0022710755,
0.009815834,
-0.0091574555,
0.017716384,
0.015388781,
0.00052620453,
-0.03229383,
-0.0064973375,
0.00053992076,
-0.0007190631,
0.01601391,
-0.005240432,
-0.0092239585,
0.014072023,
0.022983417,
0.027292809,
0.01624002,
-0.012522505,
-0.011305501,
-0.0027482342,
-0.0033284724,
0.010228153,
-0.038438704,
-0.021493752,
-0.0008628757,
0.018421317,
0.008652033,
0.010228153,
-0.012076935,
-0.02460609,
0.0013126018,
-0.035299763,
0.025803143,
0.017064655,
0.0036044596,
-0.0063310806,
0.0044623474,
0.024087366,
-0.0067600245,
-0.0067201224,
0.032825854,
0.019724773,
-0.016186817,
0.006118271,
0.0051107514,
0.016532632,
0.005649425,
0.02440658,
0.027346011,
-0.024393281,
0.020602612,
0.010354509,
0.03072436,
0.004475648,
0.007947102,
0.016905049,
-0.0024988481,
-0.014537544,
0.027824832,
-0.03210762,
-0.014045422,
-0.01105944,
-0.0054066894,
0.0119838305,
0.008884793,
-0.011850825,
-0.0015395432,
-0.01941886,
0.02124104,
-0.0039369743,
-0.0052903094,
0.0015769511,
0.030218938,
0.014311434,
0.003980201,
0.0062413015,
0.002866277,
0.006460761,
0.0065605156,
0.03178841,
-0.02167996,
0.017117858,
-0.015628193,
0.022611002,
0.0077741942,
-0.03250664,
-0.004126508,
0.0015162672,
-0.04266829,
-0.0052969595,
0.025257818,
-0.0203233,
0.08310208,
0.019751374,
-0.0061548473,
0.009290461,
-0.00768109,
0.011651316,
0.028835677,
0.024592789,
-0.033091865,
-0.02527112,
0.02573664,
-0.04107222,
0.013613153,
-0.04647226,
-0.026055854,
0.029952927,
-0.013300589,
-0.0045488016,
0.015455284,
-0.0059653143,
0.008785039,
-0.013992219,
0.02412727,
0.015455284,
-0.027638623,
0.012143438,
0.017224263,
-0.02282381,
0.0039901766,
-0.01557499,
0.01605381,
0.008246365,
-0.061555125,
-0.0046186293,
-0.002159683,
-0.0009185719,
-0.0035246562,
-0.04272149,
0.0149897635,
0.026468173,
0.008000304,
0.006464086,
-0.0158144,
-0.01694495,
0.012542455,
-0.012954773,
-0.014830156,
-0.012269793,
0.005104101
] |
Nonreplicating and metabolically quiescent bacteria are implicated in latent tuberculosis infections and relapses following "sterilizing" chemotherapy. However, evidence linking bacterial dormancy and persistence in vivo is largely inconclusive. Here we measure the single-cell dynamics of Mycobacterium tuberculosis replication and ribosomal activity using quantitative time-lapse microscopy and a reporter of ribosomal RNA gene expression. Single-cell dynamics exhibit heterogeneity under standard growth conditions, which is amplified by stressful conditions such as nutrient limitation, stationary phase, intracellular replication, and growth in mouse lungs. Additionally, the lungs of chronically infected mice harbor a subpopulation of n | [
-0.02254831,
-0.023552267,
-0.0011328423,
-0.037336312,
-0.014923671,
-0.0077263913,
-0.017257191,
-0.0025353283,
-0.03649516,
-0.001083662,
0.011966071,
0.019753514,
0.040510982,
0.008608244,
0.0037071756,
-0.011871102,
0.03774332,
0.0039072884,
0.012339163,
-0.014218188,
-0.007814577,
0.0050503057,
0.0039954735,
-0.01735216,
-0.0026845648,
0.0022131125,
0.016470306,
-0.03242507,
-0.00187733,
-0.0026116425,
0.0005325037,
-0.0149779385,
-0.017935539,
-0.01237308,
-0.014991506,
-0.028273573,
0.019658545,
-0.0112063205,
0.018749557,
0.011213103,
-0.0032408107,
0.019224402,
-0.009184841,
0.014964372,
0.00039407818,
0.005986427,
0.008018081,
-0.0019519483,
-0.012379863,
-0.015547751,
0.008933852,
-0.0005804121,
-0.032967746,
0.009700386,
-0.013261717,
-0.0050842236,
-0.0032323315,
0.03120404,
-0.011891453,
-0.021571487,
-0.02914186,
-0.01735216,
-0.04083659,
0.010059911,
-0.024827562,
0.012162792,
-0.0066037243,
0.0078552775,
0.014665899,
0.0031611049,
0.030688494,
0.023172392,
0.005643861,
0.00306444,
0.009313728,
-0.026862608,
-0.017596364,
0.022059899,
-0.0065121474,
0.010921414,
0.006688518,
-0.013600891,
-0.019617844,
0.019088732,
0.022697547,
-0.002328432,
-0.0075025363,
0.006149231,
-0.00017435681,
-0.00011775709,
0.016307503,
0.034758586,
0.026509866,
0.027351018,
-0.012780089,
0.006698693,
-0.008058783,
0.035898212,
-0.015696988,
-0.023389462,
-0.017949106,
-0.005999994,
-0.0074211345,
-0.023023155,
-0.0027150905,
0.036278088,
0.0063357768,
-0.022195568,
0.019251535,
-0.02783943,
-0.026550567,
0.029955877,
0.0046873894,
-0.053074002,
0.02093384,
0.0038258866,
0.023131689,
-0.011586196,
0.005443748,
-0.034324445,
0.01338382,
0.009150923,
0.0073329494,
-0.020581098,
0.015181444,
-0.009205191,
0.004310906,
0.0008046911,
-0.009184841,
-0.0010209148,
-0.009340861,
0.013336335,
-0.0022979062,
0.026754072,
-0.0011531927,
-0.009218759,
-0.014516662,
-0.016700944,
-0.02264328,
-0.04078232,
-0.005450532,
0.036278088,
-0.009476531,
-0.017691333,
0.0050706565,
0.016687378,
0.025614446,
0.017379293,
-0.004955337,
0.0029847343,
0.009374779,
-0.026035022,
-0.0011226671,
-0.0093815625,
-0.0063222097,
0.011063867,
-0.0028185388,
0.016443172,
-0.02873485,
-0.015710555,
-0.019617844,
0.011355557,
0.019468607,
0.020418296,
0.022629712,
0.029033324,
0.037092105,
-0.008899935,
0.00999886,
-0.008520059,
-0.0004956185,
0.021164479,
-0.017338593,
0.026075723,
-0.010731476,
0.018912362,
-0.020228358,
0.00082122587,
-0.01402825,
-0.0117150815,
-0.011552278,
0.01591406,
0.023090988,
0.0073329494,
-0.013322768,
0.00999886,
0.009327294,
0.0055590672,
0.01587336,
-0.010487271,
0.00050197804,
0.0053894804,
0.008208019,
-0.000030446197,
-0.63515145,
-0.011966071,
-0.008228369,
-0.03294061,
-0.010059911,
0.0065155393,
0.0063018594,
-0.0024013543,
-0.021883529,
0.023172392,
0.012468048,
0.012630852,
0.03182812,
-0.022494042,
-0.007862061,
-0.032316532,
-0.009775004,
0.017067254,
0.005440356,
0.009741087,
-0.010677208,
0.008798182,
-0.0147473,
0.02756809,
-0.0028338016,
0.009490098,
0.026333496,
0.00033387475,
-0.004782358,
0.025533045,
-0.032072324,
0.028409243,
0.004677214,
-0.008716781,
0.050984688,
-0.0077603087,
-0.010134529,
0.0250175,
0.02182926,
0.024569789,
-0.013845096,
-0.00046678868,
0.019075165,
0.0058507575,
-0.008859234,
0.021897096,
-0.00028363455,
0.0026286012,
-0.0045144106,
-0.023606533,
0.00404635,
0.0013117568,
-0.033836033,
0.018586753,
0.027947966,
0.009625767,
0.010778961,
-0.0054776655,
0.0018468043,
0.013797612,
0.009483314,
0.0065257144,
0.006240808,
0.0029915178,
-0.04620911,
0.028761985,
-0.015140742,
-0.010616157,
0.01824758,
-0.01268512,
0.009842839,
0.032262262,
-0.0077535254,
0.005667603,
0.0020672677,
0.03796039,
-0.008553977,
0.0037817939,
0.0041209683,
0.0038937214,
0.0021825868,
-0.011837184,
-0.038801543,
-0.0122238435,
0.011728649,
-0.013804396,
-0.025424508,
0.00433804,
-0.008472575,
0.031014102,
0.0032170685,
0.023769338,
-0.0019790824,
-0.038068928,
-0.026252095,
0.02663197,
0.0056201187,
0.005196151,
-0.0049315947,
-0.018885227,
-0.04468961,
-0.015995461,
0.031936657,
0.012176359,
0.013336335,
-0.010500837,
-0.03703784,
-0.008465791,
0.018234013,
-0.019170133,
0.009585067,
-0.020540398,
0.001785753,
-0.006003386,
0.0015415474,
-0.031583913,
0.04962799,
0.005911809,
0.008954203,
-0.03030862,
0.004918028,
0.003846237,
0.0060780044,
-0.015072907,
-0.0020180873,
0.013200665,
0.037499115,
0.0020537006,
-0.0038937214,
-0.0019790824,
-0.00047653995,
0.01237308,
0.034867123,
-0.026754072,
0.035219863,
0.008397956,
0.015927628,
-0.009937808,
-0.001732333,
-0.037173506,
-0.032289397,
-0.018030507,
0.011586196,
0.0027422246,
0.0096800355,
-0.017908406,
-0.026523434,
-0.0016984155,
0.01927867,
-0.0029321623,
0.0019858656,
0.01873599,
0.0066444254,
0.023633668,
0.029955877,
-0.009286594,
-0.021191612,
-0.042518895,
-0.0040667,
0.0062068906,
-0.0050265635,
-0.003981907,
0.0036664747,
0.01519501,
-0.024230614,
-0.013064995,
0.003276424,
-0.011423391,
0.0117150815,
-0.03329335,
0.0041447105,
-0.02663197,
0.00037733145,
0.004717915,
0.010928197,
0.00036821613,
-0.023213092,
-0.0024573181,
-0.008085916,
-0.010867146,
0.0005316558,
-0.008845666,
0.0010344817,
-0.008187668,
0.035979614,
0.023213092,
0.03079703,
-0.016036162,
0.010765393,
0.03787899,
0.0024607098,
0.016036162,
-0.025668714,
0.0055183666,
0.007733175,
-0.0023860915,
0.011857535,
0.029223261,
0.014516662,
0.02838211,
-0.013058212,
-0.01941434,
0.005091007,
-0.03039002,
0.0002076383,
-0.03720064,
-0.006081396,
-0.023375895,
0.01708082,
0.00076441414,
0.011301289,
0.0108467955,
-0.013431304,
-0.00013503378,
-0.0051452746,
0.02515317,
0.004083659,
0.003305254,
-0.022697547,
-0.011328423,
-0.01999772,
-0.006664776,
0.0050536976,
0.0024013543,
-0.021490086,
0.00766534,
-0.0055997684,
0.022846783,
-0.009734304,
0.0075432374,
-0.011443743,
0.022887485,
0.024827562,
-0.009110223,
0.015805524,
0.01855962,
-0.0006317122,
0.0008305532,
0.032126594,
0.004402483,
-0.020947408,
0.0032882951,
0.012325595,
0.0032408107,
0.006647817,
0.014245322,
0.033374757,
0.0034544906,
-0.01387223,
-0.016321069,
-0.009808922,
-0.0022436383,
-0.0338089,
0.00026116424,
-0.011755782,
-0.018844526,
0.010073478,
-0.00084708794,
0.043739922,
0.017162222,
-0.000101699305,
-0.0020384379,
-0.00067750074,
-0.02281965,
0.022209136,
-0.0004650928,
-0.001756923,
-0.00943583,
-0.0056642117,
0.025478777,
-0.016293935,
0.0026319928,
0.008974553,
-0.043956995,
-0.0019875616,
0.000020151725,
-0.009089872,
0.011979638,
0.005341996,
-0.004504235,
-0.004005649,
-0.016823048,
0.02340303,
0.018817393,
-0.0058066645,
-0.030959833,
-0.023063855,
-0.0006554544,
-0.00811305,
0.0005736286,
0.019834915,
0.009117006,
0.0018959845,
0.010880712,
-0.011511577,
0.0010209148,
0.033429023,
-0.025438076,
0.009544366,
0.0060203443,
-0.00073304056,
-0.005470882,
0.0032323315,
-0.0063256016,
0.024786862,
-0.007163362,
0.016321069,
-0.010772177,
-0.010962115,
-0.004639905,
-0.0073058154,
-0.003159409,
-0.0052572023,
0.0077603087,
-0.003133971,
0.022833217,
-0.014448827,
-0.0136890765,
0.030281484,
-0.019048031,
-0.015669854,
-0.024067812,
-0.016605975,
-0.006315426,
0.0368479,
0.0028015801,
-0.015832659,
0.007895978,
0.0025149777,
0.009117006,
0.012583368,
-0.019821348,
0.01676878,
-0.025465209,
-0.012793656,
-0.0036393406,
0.023457298,
0.013051429,
0.0012142442,
0.012902192,
-0.0043414314,
-0.022019198,
-0.01990275,
-0.0038665875,
0.013051429,
-0.012291678,
0.005921984,
0.02013339,
0.037173506,
-0.011592979,
0.0051724087,
-0.0080927,
0.010989249,
-0.022019198,
-0.013641592,
0.023972843,
-0.011830401,
0.02416278,
0.014408126,
-0.018532487,
0.017650632,
0.02200563,
-0.0161854,
0.008737131,
0.0058202315,
0.03546407,
0.01877669,
0.019550009,
0.024868263,
-0.0009581675,
-0.006227241,
0.02344373,
-0.0015364598,
-0.014489528,
0.051038954,
-0.012176359,
-0.021557922,
-0.028273573,
0.016293935,
0.018261146,
-0.0006541825,
-0.018071208,
-0.0072379806,
-0.00721763,
-0.020866005,
-0.027269617,
0.03348329,
-0.007570371,
-0.032696407,
0.0032526818,
-0.019305803,
-0.006922548,
-0.0325336,
0.002262293,
-0.011104568,
-0.0088117495,
-0.021367984,
0.010439786,
0.009178057,
0.021951362,
0.014286024,
-0.010270199,
-0.038421668,
0.016741645,
-0.02075747,
0.007692474,
0.0010005643,
-0.047403004,
-0.0025285447,
-0.019197268,
0.015045773,
-0.0027473122,
-0.03787899,
-0.0024912355,
0.012176359,
-0.030471422,
0.006698693,
-0.009327294,
-0.0053182538,
0.015751256,
0.011199537,
0.013309201,
0.002552287,
-0.023986408,
-0.004524586,
-0.02246691,
0.0027863171,
-0.013784045,
-0.011226671,
-0.026754072,
-0.03155678,
0.0103990855,
-0.010867146,
-0.0038224948,
0.019048031,
-0.017474262,
0.0052402434,
0.01091463,
0.022358373,
0.0076178554,
-0.011545494,
0.005450532,
0.012203493,
0.0048332345,
0.0031034453,
0.016443172,
0.020608233,
0.0131531805,
-0.00959185,
0.014082518,
-0.00094460056,
-0.035708275,
-0.018953063,
0.00499943,
0.0037071756,
0.020241925,
-0.011938937,
-0.048217025,
-0.048488364,
-0.008106267,
0.007909546,
0.01533068,
0.0076721236,
-0.017677767,
-0.0047043483,
0.02626566,
0.004375349,
0.00008097787,
0.026550567,
-0.032642137,
-0.0035850727,
0.009211975,
-0.00097597414,
0.011172403,
-0.0021605405,
0.0037716187,
-0.004762008,
0.002087618,
-0.02887052,
-0.025614446,
-0.0028897654,
-0.023253793,
0.04118933,
0.010745043,
0.03106837,
0.0139604155,
0.011213103,
0.016456738,
0.008777832,
0.00018347212,
-0.0006444312,
0.004334648,
-0.0018705465,
0.018790258,
0.014041818,
0.011274155,
-0.00824872,
-0.0060847877,
0.011219887,
0.034758586,
-0.008703213,
-0.0023640452,
-0.01797624,
-0.016009029,
-0.04170488,
0.0010115874,
-0.015656287,
-0.0050808317,
-0.019210834,
-0.015832659,
0.019346504,
-0.007570371,
0.010521188,
-0.001584792,
0.024203481,
-0.01855962,
0.038068928,
-0.018627455,
0.010317683,
-0.02200563,
-0.00898812,
-0.009157707,
-0.022656847,
0.009178057,
-0.0070955274,
0.013600891,
0.010738259,
0.01443526,
0.0065257144,
-0.007380434,
-0.026455598,
-0.028816251,
-0.018532487,
-0.008038431,
-0.03725491,
0.0027405287,
-0.02389144,
-0.024719026,
-0.0073940004,
0.008397956,
-0.0007745894,
0.018627455,
-0.014910104,
-0.0009106831,
0.04672466,
0.0048264507,
0.022059899,
-0.005918592,
0.013906148,
0.009842839,
-0.010324467,
-0.015588453,
-0.014163921,
-0.020879572,
-0.0191023,
0.029331798,
0.014964372,
0.0034714493,
0.00078561256,
0.029847343,
-0.0049282033,
0.004439792,
-0.032750674,
0.012841141,
-0.0060712206,
-0.017609932,
-0.017989807,
-0.018980196,
-0.01784057,
0.0008869409,
-0.018410383,
0.015642721,
0.0053589544,
-0.012162792,
-0.010229498,
-0.0015839442,
-0.0088728005,
0.003225548,
-0.033320487,
-0.008486142,
-0.0028541521,
-0.012739388,
-0.02447482,
0.002023175,
-0.013824746,
0.03334762,
-0.0055217585,
0.0112063205,
0.016253235,
0.0109078465,
-0.021897096,
0.009395129,
-0.01457093,
0.045530763,
-0.023850739,
-0.006678343,
-0.0034833204,
0.022955319,
0.014313157,
-0.020540398,
0.0029542085,
-0.008418307,
-0.0051079653,
0.006013561,
0.018505352,
0.011450525,
-0.0029440334,
-0.015425649,
-0.013349902,
0.012156009,
-0.0016992635,
-0.030362887,
-0.0023979626,
-0.041569207,
0.012027122,
0.0009700386,
0.020241925,
0.036278088,
-0.009239109,
-0.000094597846,
-0.029168993,
0.035626873,
-0.018953063,
0.03242507,
0.0011201233,
-0.02281965,
-0.014245322,
0.0029423374,
0.0017620107,
-0.032832075,
0.0069666407,
-0.020716768,
-0.0052945116,
-0.018491784,
-0.007848494,
0.016307503,
-0.015642721,
-0.022778949,
0.012807223,
0.0120746065,
0.0066240747,
-0.009137357,
-0.0035511553,
0.03017295,
0.0008801574,
0.020771036,
0.012644419,
-0.011247021,
0.004293947,
-0.00046594074,
-0.013221016,
0.0022572053,
-0.0073125986,
-0.010351601,
-0.008947419,
0.030010145,
-0.01784057,
0.006234024,
0.010412652,
-0.017732035,
-0.012610502,
0.018844526,
-0.003795361,
0.013085346,
-0.021327283,
-0.003741093,
0.0016161657,
0.0031000534,
-0.016375337,
0.011721865,
0.022711113,
-0.008703213,
-0.033239085,
-0.010134529,
-0.019685678,
0.036142416,
-0.0024827563,
-0.0017221577,
-0.018858094,
0.005674387,
-0.030688494,
-0.011572628,
0.013797612,
0.009490098,
-0.0031305791,
0.0056167273,
-0.02192423,
0.013702643,
-0.012027122,
0.026347063,
-0.002496323,
-0.0139604155,
0.02488183,
-0.00253872,
0.031366844,
0.001756923,
-0.03106837,
0.017067254,
0.026781205,
0.0032849035,
-0.012603719,
0.01735216,
-0.0013923107,
0.0152764125,
-0.0081334,
-0.0010980769,
-0.012501966,
0.034460112,
0.03497566,
0.0028083636,
-0.013485571,
0.018613888,
0.03831313,
-0.0016695857,
0.009157707,
0.0013990941,
0.019143,
0.01824758,
-0.010073478,
-0.024786862,
0.023023155,
-0.012142441,
0.024542656,
0.029331798,
0.03133971,
0.014625197,
0.0018061034,
-0.023864307,
-0.007360083,
-0.0006325602,
-0.0279751,
-0.016863748,
0.011063867,
-0.01577839,
-0.010616157,
0.008757481,
-0.0031899347,
0.014991506,
-0.009164491,
0.0055862013,
-0.019265102,
-0.010561889,
0.0149779385,
0.0046195546,
-0.005569243,
-0.0109960325,
-0.003066136,
-0.027364586,
-0.008689647,
0.008771049,
-0.00050409784,
-0.013078563,
0.01923797,
-0.022168435,
-0.011043517,
0.0037885774,
-0.0048162756,
0.00232504,
-0.007014125,
0.029250395,
0.17995234,
-0.0055285417,
0.0063018594,
-0.003978515,
0.0019468607,
-0.0059830355,
0.006807229,
-0.01931937,
-0.010575456,
0.016958717,
0.03581681,
0.0016975675,
0.018586753,
0.0056370776,
-0.0025997714,
0.00838439,
-0.019794215,
-0.006579982,
-0.019170133,
-0.014001117,
-0.01663311,
-0.0155748855,
0.010650074,
-0.0041413186,
0.0324522,
-0.0069802077,
-0.030824164,
-0.008526843,
0.006454488,
0.0012829269,
-0.01402825,
-0.0048468015,
-0.00089965994,
-0.012067823,
0.014896537,
0.004443184,
-0.0142588895,
-0.00955115,
0.008655729,
0.00885245,
0.011796484,
0.02039116,
-0.00014754084,
-0.017786302,
-0.0067597446,
0.022955319,
-0.015791956,
0.004195587,
-0.0045856372,
-0.0082148025,
-0.025587313,
-0.0045008436,
-0.0045890287,
0.012563017,
0.0041141845,
-0.013037861,
0.013526273,
0.022982454,
-0.027893698,
0.023335194,
-0.026319928,
0.005884675,
-0.037689053,
-0.008594678,
-0.012318812,
0.03513846,
-0.016009029,
0.029738806,
-0.0038665875,
-0.029087592,
0.021218747,
0.0016076864,
-0.029033324,
-0.0061933235,
-0.0030254351,
0.0020113038,
0.0126715535,
0.015819091,
0.026414897,
0.005406439,
0.0021062726,
-0.0035782892,
-0.036250953,
-0.0027150905,
-0.008452225,
-0.014462394,
0.017040119,
0.005735438,
-0.027947966,
-0.008180885,
0.0058100563,
-0.018749557,
-0.008180885,
-0.0049655125,
0.028029367,
-0.010229498,
-0.014123219,
0.000010029491,
0.005430181,
-0.042030483,
-0.040321045,
0.07445555,
0.018342549,
-0.000004739829,
-0.0035274131,
0.017338593,
-0.009883541,
-0.010276983,
0.0041040094,
-0.011721865,
0.0141096525,
-0.016782347,
0.00043181132,
-0.009673252,
0.0025200653,
0.021693591,
0.0294946,
-0.036820766,
0.03657656,
-0.0039445977,
0.011436959,
-0.004548328,
-0.0020265668,
-0.0008436962,
-0.0062577664,
-0.013200665,
-0.00398869,
0.004192195,
-0.002496323,
-0.028761985,
-0.015520617,
0.008262287,
-0.017365726,
-0.0076585566,
0.015479917,
0.0052504186,
0.0008394565,
-0.010785744,
-0.035925347,
0.019088732,
-0.014815135,
0.002618426,
0.009741087,
0.0070616095,
0.005206326,
-0.03030862,
0.018396815,
0.011274155,
-0.012264544,
-0.024719026,
0.0026082506,
-0.027174648,
-0.026930442,
0.0077942265,
0.013817962,
-0.0067495694,
-0.03299488,
-0.036115285,
-0.02838211,
0.028761985,
-0.034107372,
-0.018410383,
0.022046331,
-0.0014262281,
0.0030220433,
0.001070943,
-0.17181215,
0.017325025,
0.022521175,
-0.0010268503,
0.03334762,
0.0054810573,
-0.0066172914,
0.0035884646,
-0.012752955,
0.015357814,
0.015832659,
0.028219305,
-0.028409243,
-0.009537582,
0.010290549,
0.016483873,
0.013885797,
0.014136787,
0.031611048,
-0.0053623463,
0.04392986,
-0.03603388,
0.028789118,
-0.016103998,
-0.0013999421,
0.0071294447,
0.0059932107,
0.029223261,
0.0007690778,
-0.019048031,
-0.037363444,
-0.004466926,
0.017827004,
-0.014123219,
0.013919715,
0.008920285,
-0.004443184,
-0.027920831,
0.0021791952,
0.0081334,
0.022941751,
0.031855255,
0.0152764125,
-0.018722424,
-0.0047111316,
0.023932142,
0.0044058748,
0.0064816214,
0.026482733,
-0.0070683933,
0.008099483,
-0.023660801,
0.006583374,
0.0013041253,
0.00396834,
-0.005074048,
-0.008899935,
0.022195568,
-0.0004587333,
-0.010934981,
-0.014286024,
-0.016158266,
0.04748441,
-0.007929896,
-0.0066681677,
-0.048135623,
0.0014330116,
-0.009429047,
0.0029050282,
0.0003347227,
-0.017732035,
-0.0006359519,
-0.015100041,
0.00375466,
0.010344817,
0.007821361,
-0.0026286012,
-0.0011718473,
-0.008336905,
0.008235153,
-0.01042622,
0.020594666,
-0.023837173,
-0.00032730325,
0.0017238535,
0.011972854,
0.0025811167,
0.023063855,
0.0026591269,
-0.007868845,
0.007387217,
-0.017026551,
0.0031661924,
-0.009605417,
0.0035409802,
0.01990275,
-0.019387206,
-0.008187668,
-0.0071701454,
0.008323338,
-0.01015488,
-0.025166737,
-0.024203481,
0.028002234,
0.04026678,
-0.0051724087,
-0.038665876,
-0.012047472,
0.047864284,
-0.015927628,
-0.018057643,
-0.00531147,
0.016416037,
0.048786838,
-0.0052538104,
0.037716188,
0.01488297,
-0.0032594653,
0.009218759,
-0.020621799,
0.07206776,
0.0030780071,
-0.030227218,
0.028707717,
0.007678907,
-0.03177385,
-0.1346929,
-0.01293611,
-0.01089428,
0.014448827,
-0.012379863,
0.032018058,
-0.011124918,
0.008757481,
0.01091463,
0.008194452,
-0.014448827,
-0.0029135076,
-0.0005380153,
-0.0066342503,
-0.008954203,
-0.002550591,
0.014693032,
0.007265114,
-0.02838211,
0.026387764,
0.005905025,
-0.0030847907,
-0.00058126,
-0.00930016,
0.021191612,
-0.0053487793,
-0.014896537,
0.0279751,
0.00015665616,
-0.00603052,
0.023063855,
-0.0065155393,
-0.0035409802,
-0.017759169,
-0.01443526,
-0.0005715088,
-0.015547751,
-0.016103998,
0.021951362,
-0.015791956,
-0.005063873,
0.04021251,
0.02752739,
0.018803826,
0.023172392,
-0.028490644,
0.0069598574,
0.019807782,
-0.00037563557,
-0.015493484,
-0.00544714,
-0.021449385,
-0.029006189,
-0.023118123,
0.02371507,
-0.01685018,
0.017827004,
0.023158824,
-0.012210276,
-0.0003451099,
0.007143012,
-0.0074211345,
-0.005230068,
0.01118597,
-0.000015130356,
-0.039072882,
-0.012590151,
-0.020608233,
0.0034901039,
-0.03456865,
0.0018807217,
-0.016795913,
-0.018328981,
-0.0155748855,
-0.03218086,
-0.0060644373,
-0.020553965,
-0.036278088,
0.01860032,
-0.005647253,
-0.0177049,
-0.0076585566,
0.016823048,
-0.02626566,
0.058826398,
0.022073466,
-0.0037987526,
0.0048061004,
-0.004850193,
0.010385518,
-0.0162668,
0.02838211,
-0.02138155,
-0.03394457,
-0.015317113,
0.022046331,
-0.013037861,
-0.008397956,
0.015724123,
0.0072990316,
-0.029413199,
-0.028761985,
-0.056113,
0.008208019,
0.006908981,
-0.0096800355,
0.0021062726,
0.0017891446,
-0.004412658,
0.0020927056,
0.014353858,
0.043468583,
-0.020730335,
0.009992076,
0.0120746065,
-0.015493484,
-0.039914038,
-0.019482175,
0.026971143,
-0.008981337,
0.0039038965,
0.023253793,
-0.004212545,
0.010385518,
0.0018908969,
0.03066136,
-0.013051429,
-0.0050536976,
0.0045652865,
0.03424304,
-0.01824758,
-0.036196686,
0.007807793,
-0.022046331,
0.016931582,
-0.0009013558,
-0.0041379267,
0.0026845648,
0.011708298,
0.013003944,
0.023959275,
0.045557898,
-0.008743915,
-0.02622496,
0.016565274,
0.00383267,
-0.0013558494,
0.020458996,
-0.03755338,
0.02976594,
-0.0043855244,
0.001756923,
0.034134507,
-0.02013339,
0.0009810617,
-0.035789676,
-0.012210276,
-0.005667603,
0.0014745605,
-0.0061831484,
-0.018830959,
-0.011762566,
0.04021251,
0.03698357,
0.01383153,
0.016103998,
-0.0031560173,
-0.009110223,
-0.008431874,
-0.011111352,
-0.009924241,
-0.03725491,
-0.015425649,
-0.0048298426,
0.020988109,
-0.002999997,
0.005871108,
-0.007746742,
-0.003961556,
0.0077942265,
-0.0007152339,
0.013044645,
0.004205762,
-0.023552267,
-0.021123778,
0.005335212,
0.04061952,
0.015032207,
-0.014774434,
0.05128316,
0.0076856907,
0.0049519455,
-0.0012727517,
0.015357814,
0.0026642145,
0.0057422216,
0.024420552,
0.0139604155,
-0.007414351,
-0.0061797565,
-0.0007542389,
0.028843386,
0.009931025,
0.002618426,
-0.0033595217,
-0.0382046,
0.012440915,
0.009775004,
-0.024027111,
-0.02963027,
-0.011735432,
0.0071158777,
0.014163921,
0.008370822,
0.0033510425,
-0.004161669,
-0.022182003,
0.011111352,
-0.01999772,
-0.02281965,
-0.0009369691,
0.045150887,
0.024461253,
0.033727497,
-0.012698688,
-0.0043821326,
0.01533068,
-0.0023419987,
0.034351576,
-0.02990161,
0.022439774,
-0.011667597,
0.04075519,
0.020513264,
-0.031041235,
-0.015262845,
-0.016646676,
-0.0064137867,
0.019658545,
0.0063629104,
-0.02626566,
0.07483543,
0.01712152,
-0.018274713,
0.017433561,
-0.023145257,
0.008838884,
0.036250953,
0.0034934958,
-0.0027931007,
-0.045937773,
0.02739172,
-0.00015867,
0.015642721,
-0.039208554,
-0.010772177,
0.042166155,
-0.004531369,
-0.00073770416,
0.0043787407,
-0.011993204,
0.003198414,
-0.012468048,
0.01519501,
-0.00086150283,
-0.017040119,
-0.011226671,
0.039778367,
-0.0062034987,
0.0017357246,
-0.021693591,
0.01443526,
-0.016198967,
-0.02336233,
-0.011328423,
0.009408697,
-0.0023589574,
-0.009700386,
-0.015710555,
0.010880712,
0.013037861,
-0.008587894,
-0.00071014627,
0.0010963811,
0.0019485566,
-0.000317128,
0.0021384943,
0.007258331,
-0.004524586,
-0.010405868
] |
In this present work, we characterized the proteomes of pancreatic ductal adenocarcinoma (PDAC) cell line PANC-1 and normal pancreatic duct cells by mass spectrometry using LTQ-Orbitrap and identified more than 1700 proteins from each sample. On the basis of the spectra count label-free quantification approach, we identified a large number of differentially expressed metabolic enzymes and proteins involved in cytoskeleton, cell adhesion, transport, transcription, translation, and cell proliferation as well. The data demonstrated that metabolic pathways were altered in PANC-1, consistent with the Warburg effect. In | [
-0.016113427,
-0.001884177,
0.008833346,
-0.040817082,
-0.003788614,
0.007165275,
-0.020151913,
0.022434536,
-0.03849394,
-0.0030812032,
0.030119818,
0.03695418,
0.008738799,
-0.00311497,
-0.0074286545,
0.010920122,
0.02451456,
-0.0160594,
-0.039061215,
-0.0069086486,
-0.039790574,
-0.0044200495,
0.0028127588,
-0.019030862,
0.0024193777,
0.024298454,
0.0063953963,
-0.017963838,
-0.0051223948,
-0.022974802,
0.0073611215,
-0.0026996406,
-0.01266248,
0.017261492,
0.0076109944,
-0.011548181,
0.007935153,
0.00641228,
0.025176385,
-0.021016339,
0.0010087775,
0.009785564,
0.012952873,
-0.010832329,
-0.010521676,
-0.0068107257,
0.006962675,
0.0027975638,
-0.005831494,
0.024284948,
-0.013911844,
0.0006576048,
-0.0014519643,
-0.0048691453,
-0.009664005,
-0.009022439,
0.001409756,
0.02205635,
-0.012703,
-0.010649989,
0.003442506,
-0.0101637505,
-0.028715126,
-0.00044445304,
0.0011210515,
0.006746569,
0.0010839083,
0.011919614,
0.016113427,
0.023352988,
0.048353788,
0.014465616,
-0.008880619,
-0.0051021352,
0.010947135,
-0.022312976,
-0.025460025,
-0.011629221,
0.0048488853,
0.024582094,
0.016653692,
-0.03128139,
-0.0066520227,
0.022893762,
0.015100429,
-0.008732046,
-0.008873866,
0.010393363,
-0.013432358,
0.004913042,
0.0005432204,
0.030281898,
0.02532496,
0.008948152,
-0.013587684,
0.005352008,
-0.011392855,
0.027648102,
-0.0026287306,
-0.03152451,
-0.008448406,
0.018531116,
-0.021124393,
-0.02282623,
-0.008779319,
-0.014654709,
0.014843803,
0.013743011,
0.013243265,
0.0062637064,
-0.016370052,
0.030741123,
-0.009880111,
-0.032632053,
0.0313084,
0.0039203037,
0.011169995,
-0.0047813524,
0.003778484,
-0.003407051,
0.015194975,
0.024987293,
0.040141746,
-0.019652167,
0.027648102,
-0.0023906762,
0.015600175,
0.0059564305,
0.0040587466,
0.01823397,
-0.00082052866,
0.000086949025,
0.03103827,
0.012892093,
-0.011291555,
0.0023265195,
0.004372776,
0.0016402132,
-0.01577576,
-0.018625664,
0.0102245305,
0.030660084,
-0.0024734044,
-0.015870307,
-0.028526034,
0.010555442,
0.013553918,
0.009657251,
0.015843295,
0.0059868204,
0.014222497,
-0.012250527,
-0.011345581,
0.005699804,
-0.00024122023,
0.015465108,
0.020827247,
0.018220464,
-0.027985768,
-0.01618096,
-0.005581621,
0.011480648,
0.001706058,
0.004696936,
0.023082856,
0.015613682,
0.031821653,
0.0102853095,
-0.010406869,
-0.012291047,
-0.002436261,
0.021489073,
-0.022758696,
0.021988818,
-0.00067068933,
0.00041596245,
0.0013312487,
-0.0044706995,
-0.029174352,
-0.023663642,
0.002292753,
0.017491104,
0.0030102935,
0.018855276,
-0.016329534,
-0.0130136525,
0.010852589,
0.014114444,
0.009765304,
-0.03301024,
0.004396413,
0.017220972,
-0.019692687,
-0.0131487185,
-0.6509122,
-0.025351971,
0.019692687,
-0.011966887,
-0.0015076792,
0.034144796,
-0.004886029,
-0.0033749728,
-0.011798054,
-0.005689674,
-0.0102042705,
0.010582456,
0.015113936,
-0.021313485,
-0.0030254885,
-0.02536548,
-0.01420899,
-0.027796675,
0.019679181,
-0.0057166875,
-0.041492414,
0.010359596,
-0.005331748,
0.014951856,
0.0008661136,
0.011055188,
0.034793116,
-0.0038629004,
0.0027570438,
0.021218939,
-0.017477598,
0.013445864,
-0.013607944,
0.0023704162,
0.040141746,
0.009245298,
-0.0024953526,
0.014884323,
0.009366858,
0.04970445,
0.01461419,
-0.0057639605,
0.0014950167,
0.016761746,
-0.048218723,
0.019571127,
0.026878223,
0.017720718,
-0.013135212,
-0.020692179,
-0.013385084,
-0.00786762,
-0.03498221,
0.0016334598,
0.010717522,
-0.012365333,
0.018693196,
-0.0367921,
0.01872021,
0.019868275,
0.046516884,
0.013797037,
-0.0101502435,
-0.033199333,
-0.0031166582,
-0.00009064225,
0.006915402,
0.010839082,
-0.0102718035,
0.009582965,
0.018085398,
0.015451602,
0.0031487364,
0.007705541,
0.020178927,
0.03490117,
0.022272456,
0.014695229,
-0.007253068,
0.0054262946,
0.030200858,
0.0039878367,
-0.03276712,
0.008786072,
0.014506136,
0.013135212,
-0.016910318,
0.021043353,
0.03160555,
0.013655217,
0.015789269,
0.0004896159,
0.0052236947,
-0.041924626,
-0.021597125,
0.020732699,
-0.026351463,
0.006567606,
-0.0040114736,
-0.030227872,
-0.020030353,
-0.02266415,
0.019989833,
-0.008043207,
0.034928184,
-0.00018012377,
-0.030173844,
0.0028617203,
0.03754847,
-0.012736766,
-0.013459371,
-0.007793334,
-0.0005305579,
-0.020111393,
0.014708736,
-0.026243411,
0.012385593,
0.015559655,
-0.0036805607,
-0.033685572,
-0.009279065,
-0.0047104424,
0.00078000873,
-0.009326338,
-0.0038899137,
0.022637136,
0.013898337,
-0.02890422,
0.023690654,
-0.0033158814,
0.0028735388,
0.00209353,
0.0025595091,
-0.005240578,
0.017869292,
0.017599158,
0.023717668,
0.009029192,
-0.012689493,
-0.036251836,
-0.012567933,
-0.013844311,
-0.006510203,
-0.006746569,
-0.027688622,
0.0013472878,
-0.023677148,
0.004875899,
0.027148357,
0.024528068,
-0.011629221,
-0.00809048,
-0.014222497,
0.007266575,
0.023407016,
-0.011129475,
-0.000041733423,
-0.014263017,
0.009947644,
-0.012068187,
-0.006814102,
0.0017035255,
-0.012946119,
-0.023596108,
-0.0008513407,
-0.011696754,
0.021502579,
0.024703654,
-0.008718539,
-0.024406508,
-0.0031993864,
0.0013582619,
0.0023214545,
0.013844311,
0.017288506,
0.0023602862,
-0.0101232305,
-0.009886864,
-0.006040847,
-0.007232808,
0.02483872,
-0.012912353,
-0.01811241,
0.004555116,
0.035036236,
0.028850192,
0.027742648,
0.00034505257,
-0.007874374,
0.046111684,
-0.01835553,
-0.0034847143,
-0.0012983262,
0.013223005,
0.012014161,
-0.0011294931,
0.0057572075,
0.0131959915,
-0.00394394,
0.019625155,
0.011163242,
-0.008853606,
-0.0010248167,
-0.0102447895,
0.020597633,
-0.021826738,
-0.00082559366,
-0.016478106,
0.021043353,
-0.002681069,
0.0038088737,
0.0032804264,
-0.02270467,
-0.0005710778,
-0.029876698,
0.024203908,
0.001987165,
-0.009441145,
0.00022412589,
-0.016761746,
-0.007935153,
-0.010704016,
0.027067317,
-0.014181977,
-0.012513907,
0.008320093,
0.01420899,
0.04697611,
-0.020232953,
-0.0035522475,
0.009697771,
0.020692179,
0.0024278194,
0.0029748385,
-0.00158281,
0.017410064,
0.03138944,
-0.0024244427,
0.04975848,
-0.006489943,
-0.0102515435,
0.00831334,
0.0066689057,
0.0070302086,
-0.0016672264,
-0.014681723,
0.019057875,
0.028607074,
-0.015789269,
0.0061725364,
0.009204779,
0.03865602,
-0.017855784,
0.011696754,
0.004463946,
-0.010737782,
0.0022032715,
0.022029338,
0.039925642,
0.00039591352,
0.0055073346,
-0.0039101737,
0.0066418927,
-0.0066250092,
-0.0015583291,
0.0059429235,
0.034495972,
-0.007475928,
-0.002007425,
0.006000327,
-0.0002614802,
-0.006378513,
0.025838211,
-0.03868303,
0.00796892,
0.01888229,
0.0030305535,
-0.011635974,
0.030498004,
0.019422555,
-0.0019314502,
-0.013398591,
0.030443978,
0.017004866,
-0.017788252,
-0.029876698,
-0.03163256,
-0.013574178,
-0.016167454,
0.0037210807,
0.007604241,
0.024082348,
0.012878586,
0.014681723,
-0.02254259,
-0.026986277,
0.009670758,
-0.021259459,
0.013526904,
0.002262363,
-0.015802775,
0.0076312544,
0.0012088447,
-0.014479123,
0.045274273,
0.014303537,
-0.0083336,
-0.032524,
0.0024041827,
-0.021786219,
-0.0102988165,
-0.009184519,
0.004143163,
0.013405344,
0.0031723732,
0.000037855538,
0.004872522,
0.01924697,
0.039115243,
0.019881781,
-0.0256086,
-0.04705715,
0.0073678745,
0.0024497677,
0.01924697,
0.021205433,
-0.00008900668,
-0.0027519788,
-0.0073611215,
0.006905272,
-0.009225038,
-0.0018200204,
0.023244936,
-0.020097887,
-0.022353496,
-0.010062451,
-0.0005297137,
-0.010541936,
0.0054161646,
0.010764795,
-0.014654709,
-0.044139713,
-0.02221843,
-0.0029680852,
-0.017693704,
-0.007084235,
0.042518917,
0.012730013,
0.021880765,
-0.006814102,
0.0064055263,
0.029687606,
0.01855813,
0.007313848,
0.0062231864,
0.021367513,
0.025189891,
0.0050784983,
-0.01252066,
-0.03203776,
0.027418489,
0.0036299108,
0.01867969,
0.023555588,
-0.004794859,
0.019355021,
0.017193958,
0.0071112486,
0.008914386,
0.001700993,
0.00006642526,
0.020165421,
0.017585652,
-0.032226853,
0.023488056,
-0.012000654,
0.0007922491,
-0.013952364,
0.023380002,
0.006101627,
0.00821204,
-0.019922301,
-0.0077798273,
-0.0043390095,
-0.0034256228,
-0.015032896,
-0.0004100533,
-0.006982935,
-0.019787235,
0.006793842,
0.0028363953,
-0.027229395,
-0.024987293,
0.0067803357,
0.000090378446,
-0.03209179,
-0.005807857,
0.01396587,
0.0020192433,
0.016937332,
0.017085906,
-0.033712585,
0.012959626,
0.0380077,
-0.012169487,
-0.012162734,
-0.0102718035,
-0.04395062,
-0.020516593,
-0.0065372162,
-0.008563213,
-0.01252066,
0.006783712,
0.009110232,
-0.012027667,
-0.019219955,
-0.002865097,
0.006756699,
-0.020678673,
0.013027159,
0.012736766,
0.013337811,
0.008853606,
0.000939556,
0.005980067,
-0.033955704,
-0.0029663967,
-0.0103055695,
0.0011733897,
-0.009177765,
-0.0010121542,
-0.0019246968,
-0.01835553,
-0.009535691,
0.008522693,
-0.0011598831,
0.0025645741,
0.0034745843,
0.025297945,
0.006982935,
-0.034063756,
0.0033901678,
-0.0041701766,
-0.018369038,
-0.001848722,
0.008022947,
0.033145305,
-0.004524726,
-0.008644253,
0.018004358,
-0.018949822,
-0.022204924,
-0.009062959,
-0.010710769,
-0.0076987874,
0.041924626,
0.0024835344,
-0.0166672,
-0.023217922,
-0.021408033,
-0.0016283948,
-0.0012476763,
0.006776959,
-0.0256086,
-0.035198316,
0.010893109,
0.011858834,
-0.0074691745,
0.006510203,
-0.03706223,
-0.027026797,
0.007975673,
-0.0035961443,
0.0009074777,
-0.00622994,
0.010427129,
-0.021272965,
0.004284983,
-0.020313993,
-0.033226345,
-0.01928749,
0.012865079,
0.04351841,
0.0433023,
0.036575995,
-0.009225038,
0.012851573,
0.012027667,
0.010595962,
0.0019263852,
-0.011811561,
-0.011237528,
-0.0012122213,
0.010933629,
0.02664861,
-0.01851761,
0.011406361,
-0.016478106,
0.023906762,
0.022596616,
-0.0030001635,
-0.024649626,
0.0075299544,
-0.024136374,
-0.036197808,
0.009157505,
-0.014830296,
-0.00794866,
-0.034171812,
-0.014073924,
0.030146832,
-0.0026641856,
0.0013633269,
-0.015492122,
0.033361413,
-0.016153947,
0.021718685,
0.00639202,
-0.011541428,
0.004494336,
-0.028526034,
-0.0102785565,
-0.0131554715,
0.0071922885,
-0.00784736,
0.026473023,
0.019841261,
-0.032956213,
0.012486893,
0.0023298962,
-0.017747732,
-0.008461913,
0.00024248648,
-0.022515576,
-0.035360396,
-0.018220464,
-0.022677656,
-0.047003124,
0.007833854,
-0.000042076364,
-0.02648653,
0.0037143272,
-0.0039979666,
-0.022245444,
0.040465906,
0.01569472,
0.027513035,
-0.029687606,
0.019773727,
0.02169167,
-0.004723949,
-0.009630238,
-0.002512236,
-0.0038088737,
-0.0006082211,
0.024609108,
0.014384577,
0.013580931,
0.009258805,
-0.007523201,
-0.0009235168,
-0.019841261,
-0.017491104,
0.00817152,
-0.008894126,
0.011683248,
-0.013770024,
-0.012932613,
-0.013378331,
-0.0068917656,
-0.0061151334,
0.0068715056,
0.0035387408,
0.007914893,
-0.01573524,
0.027067317,
-0.0014992376,
0.01827449,
0.001460406,
-0.029498512,
0.005851754,
-0.020246461,
-0.019895287,
-0.00636163,
-0.0050616153,
0.008630746,
0.011750781,
0.0048522623,
0.0047408324,
0.0065878658,
-0.0018419686,
-0.0074691745,
0.003498221,
0.038304843,
0.009035945,
-0.0003834621,
0.015357055,
-0.015221989,
0.0132972915,
0.007732554,
-0.004426803,
-0.028444994,
-0.03892615,
0.009373612,
0.015316535,
0.018085398,
-0.009272312,
-0.009765304,
-0.017842278,
-0.013857817,
-0.02274519,
-0.03590066,
-0.00083403534,
-0.041708518,
-0.027648102,
-0.0074421614,
0.012905599,
0.03835887,
0.012061434,
-0.00098092,
-0.023285456,
0.03498221,
-0.0018622286,
0.021516085,
0.003018735,
-0.013047419,
-0.02213739,
-0.004183683,
-0.029390458,
-0.0014747567,
0.013743011,
-0.018085398,
-0.011102462,
-0.026081331,
-0.01252066,
0.0103258295,
0.025216905,
-0.002476781,
0.0045179725,
0.017450584,
0.003361466,
0.004203943,
-0.030065792,
0.00019004272,
-0.03606274,
0.002216778,
0.011460388,
-0.015492122,
-0.024501054,
-0.005328371,
-0.037818607,
-0.009319585,
-0.004994082,
-0.013391838,
-0.040817082,
0.007482681,
-0.014222497,
0.0079284,
-0.0132567715,
-0.0022556097,
-0.016478106,
0.016086414,
0.01855813,
-0.010879602,
-0.012966379,
0.0021458683,
0.00063861103,
-0.009826084,
-0.015681215,
-0.01896333,
0.0024598977,
-0.016262,
-0.017193958,
-0.00040372205,
-0.033820637,
0.019949315,
0.01654564,
-0.02524392,
-0.02435248,
0.020070873,
-0.037899643,
-0.017329026,
-0.016518626,
0.022974802,
-0.0027401606,
0.028634086,
-0.0032399064,
0.0039506936,
0.014681723,
0.004264723,
-0.009083219,
-0.037980683,
0.023055842,
-0.01863917,
0.027823688,
-0.01670772,
-0.025419505,
-0.022596616,
0.009778811,
0.0038426404,
0.0025156126,
0.008245806,
-0.026162371,
0.01790981,
-0.026797183,
0.01416847,
0.0038831604,
0.013938857,
0.016991358,
-0.019868275,
-0.012068187,
0.02504132,
-0.0130541725,
0.002930942,
0.0047003124,
0.019557621,
0.0026911988,
0.0036704307,
-0.002343403,
-0.023731174,
0.015249002,
-0.009488418,
0.00008399445,
-0.0012223513,
-0.009805824,
0.021826738,
0.018652676,
-0.0014882634,
-0.011696754,
-0.01835553,
-0.009373612,
0.0023872994,
0.0053655147,
-0.011068695,
0.0004474076,
-0.007793334,
0.015883815,
-0.029471498,
0.0040992666,
-0.0102515435,
0.0033834146,
-0.018450076,
0.008941399,
0.009326338,
-0.01416847,
-0.030741123,
-0.00067491014,
-0.023407016,
-0.0031335417,
-0.00008663246,
-0.0049704453,
-0.026189385,
-0.015883815,
-0.0038358872,
-0.010474403,
0.00788788,
-0.011230775,
-0.036440928,
-0.016113427,
-0.0028380838,
0.1796924,
-0.011568441,
0.0061556534,
0.027580569,
0.007104495,
-0.00077705417,
-0.016126934,
0.005449931,
-0.003396921,
0.00160307,
0.022083364,
-0.009029192,
-0.0037210807,
-0.0012282605,
0.017842278,
0.011818314,
-0.039925642,
-0.013040666,
0.0017136555,
0.008326846,
-0.018369038,
-0.016072907,
0.027404983,
0.0067904657,
0.0074083945,
-0.009913878,
-0.0025476909,
-0.008360613,
0.028688114,
0.025946265,
-0.022920776,
0.019841261,
-0.01803137,
0.021137899,
0.0034560128,
0.012831313,
-0.0059935735,
-0.01614044,
0.014776269,
-0.020813739,
0.0043423865,
-0.0050379783,
-0.008995425,
0.0009615043,
-0.021191925,
-0.00207327,
-0.004295113,
-0.0009404001,
0.017342532,
-0.0005854286,
-0.03698119,
0.038223803,
0.035036236,
0.01573524,
0.0035657543,
-0.0035488708,
-0.0039574467,
0.016653692,
-0.0012578063,
0.033847652,
-0.027472515,
0.008245806,
-0.023623122,
0.0367921,
-0.013506644,
0.009258805,
-0.0043288795,
0.0055748676,
0.024852226,
-0.01932801,
0.0004402322,
0.004676676,
0.00014836204,
-0.016329534,
-0.010548689,
-0.007063975,
0.0380077,
0.0020040483,
0.00784736,
0.010704016,
0.027661609,
-0.0008948152,
-0.03225387,
-0.009387118,
-0.020070873,
-0.013243265,
0.016653692,
-0.002237038,
-0.0016191091,
-0.0050751218,
0.010440636,
-0.017572144,
-0.024663134,
-0.0022893762,
0.011122722,
-0.0037447172,
0.0045314794,
-0.003727834,
0.008698279,
-0.020205941,
-0.025189891,
0.076933846,
0.0029697735,
0.022191416,
-0.014654709,
0.001179299,
-0.033145305,
0.023974294,
0.01630252,
-0.010420376,
0.0054465546,
-0.016451092,
-0.0024885994,
-0.026202891,
-0.023217922,
0.022758696,
0.015276015,
-0.01609992,
0.034360904,
-0.014951856,
-0.008900879,
-0.018531116,
0.013952364,
-0.002885357,
-0.008732046,
0.011278048,
-0.01272326,
-0.015086922,
0.0071517685,
-0.020881273,
-0.0032871796,
-0.005318241,
-0.005659284,
0.013351318,
-0.011163242,
-0.0030052285,
0.010656742,
0.01634304,
-0.014425096,
0.016613172,
-0.008934646,
0.015411082,
-0.0024531444,
0.020881273,
0.004727326,
-0.008367366,
0.017531624,
-0.003528611,
0.0043997895,
-0.022394016,
-0.010812069,
-0.0028870453,
-0.026864717,
-0.004946809,
0.016680706,
-0.01453315,
-0.018828264,
-0.0082323,
-0.008779319,
-0.010879602,
-0.02898526,
0.0062772133,
0.017558638,
-0.00023742148,
0.0009108544,
-0.012446373,
-0.17180452,
0.013087939,
0.022110377,
-0.014465616,
0.017531624,
0.015370562,
0.0060037035,
0.0034289993,
0.0036299108,
0.012007407,
0.009582965,
-0.026662117,
-0.03690015,
0.009461405,
0.008799579,
0.00018803783,
-0.0019213202,
0.025946265,
0.008164767,
-0.011608961,
0.035954688,
-0.00407563,
-0.0042782295,
-0.005389151,
-0.00047737546,
0.013432358,
-0.000016856926,
-0.005841624,
-0.019733207,
-0.023150388,
-0.011041682,
0.0054364246,
0.02266415,
0.0048488853,
0.010487909,
0.012858326,
-0.01424951,
-0.0055140876,
0.0002973572,
0.013857817,
0.030281898,
0.029012272,
0.0055073346,
0.004376153,
0.006557476,
0.03128139,
0.0037953672,
-0.002844837,
0.020259967,
0.0131892385,
0.03268608,
-0.021448553,
0.0131284585,
0.03365856,
0.018247478,
0.021880765,
0.01211546,
0.017437078,
-0.007854114,
-0.006895142,
-0.005649154,
-0.013688984,
0.031740613,
-0.0013194303,
-0.009076465,
-0.027364463,
-0.01453315,
-0.0031774382,
-0.019908795,
0.011075448,
-0.02238051,
-0.023447536,
0.0034745843,
-0.018747224,
0.00798918,
0.018301504,
-0.027499529,
-0.014992376,
0.013770024,
0.0032956214,
-0.0061050034,
0.0035218576,
-0.026013797,
-0.0026979523,
-0.007604241,
-0.002829642,
0.009110232,
0.036494955,
-0.013634957,
0.0006107536,
0.027337449,
-0.02169167,
-0.005281098,
-0.02668913,
0.020462567,
0.023312468,
-0.030119818,
-0.0036231575,
0.0012578063,
-0.016910318,
0.01211546,
-0.013486384,
-0.020678673,
0.035468448,
0.03784562,
0.015086922,
-0.033982717,
-0.0022691162,
0.03900719,
-0.018179944,
-0.022029338,
0.010670249,
0.006955922,
0.01457367,
0.0057166875,
0.047732484,
-0.0042478396,
-0.004686806,
-0.0028380838,
-0.01847709,
0.06331915,
0.01670772,
0.0131892385,
0.024933266,
0.011608961,
-0.018531116,
-0.13204096,
-0.025311451,
0.016991358,
0.040168762,
-0.017464092,
0.0101840105,
-0.0008293924,
0.015140949,
-0.027877714,
0.033766612,
0.0013565737,
-0.008590226,
-0.00037628668,
-0.011696754,
0.024730666,
-0.006962675,
0.02282623,
-0.011912861,
-0.025541065,
0.018612156,
0.0048522623,
0.011210515,
0.015951347,
-0.0047610924,
0.014303537,
-0.00786762,
-0.025716651,
0.043167237,
0.007023455,
0.0075704744,
0.021556605,
-0.00020428801,
0.035144288,
-0.0040486166,
-0.009062959,
-0.0042174496,
-0.004632779,
-0.027715635,
0.04303217,
0.0032534131,
0.012939366,
0.010609469,
0.002605094,
-0.025392491,
0.010670249,
0.00029461368,
-0.01573524,
-0.0058956505,
0.007624501,
-0.023231428,
-0.01412795,
-0.001823397,
-0.01867969,
-0.014019897,
0.008448406,
-0.03827783,
0.013560671,
0.023488056,
-0.008995425,
-0.021029845,
-0.0033986096,
0.0065709827,
0.0045517394,
0.008563213,
0.019625155,
-0.0020209318,
-0.01859865,
-0.009907124,
0.024460534,
-0.01827449,
0.011001162,
-0.01815293,
-0.002338338,
-0.029336432,
-0.02664861,
-0.015627189,
-0.0059564305,
0.010008424,
-0.008131,
-0.021475565,
-0.0035623775,
-0.029768646,
-0.0121965,
-0.018369038,
0.023920268,
0.001894307,
0.03192971,
-0.0027502906,
0.005480321,
-0.0065979958,
-0.014438603,
0.030092804,
0.015370562,
-0.009393872,
-0.03744042,
0.016653692,
0.01589732,
-0.020259967,
-0.008259313,
0.020908287,
-0.03047099,
-0.015059909,
-0.052324742,
-0.0037514705,
-0.0025037942,
-0.013783531,
0.008927892,
-0.019071382,
-0.018706704,
-0.000944621,
0.014884323,
0.030660084,
-0.03184867,
0.013371578,
0.00058078574,
-0.008556459,
-0.01420899,
-0.0074016415,
0.023461042,
-0.0028937985,
0.002348468,
0.024771186,
0.010974149,
0.000183817,
0.0049299253,
0.0024176894,
-0.028553046,
-0.0054060346,
-0.025851717,
0.041222278,
-0.009319585,
-0.029903712,
0.004264723,
-0.03711626,
-0.0062164334,
0.0029630202,
-0.022123884,
-0.018895796,
-0.021354005,
0.00023636628,
0.026324451,
0.028282914,
0.0042917365,
-0.030038778,
-0.004494336,
0.004612519,
-0.009319585,
0.0055073346,
-0.026216397,
-0.00019436906,
-0.0033361414,
-0.0031993864,
0.043086197,
0.012554427,
0.0130946925,
-0.02487924,
-0.0019517102,
0.00619955,
0.0102650495,
-0.020611139,
-0.006976182,
-0.018774236,
0.046219736,
0.008752306,
0.03201075,
-0.008124247,
-0.0012966379,
0.012730013,
-0.016896812,
-0.014073924,
-0.010177257,
-0.011156488,
0.0052270717,
-0.00804996,
0.02242103,
0.026229903,
0.020395033,
-0.009562705,
-0.012270787,
0.008002687,
0.008759059,
0.011169995,
0.013040666,
0.013709244,
-0.012432867,
0.017072398,
0.025135865,
0.0068883887,
-0.008948152,
0.015870307,
0.008779319,
0.0065169563,
-0.010980902,
0.0064224093,
0.0012130656,
0.0027958755,
-0.009535691,
-0.004865769,
-0.0017575521,
-0.015194975,
0.006307603,
0.018990342,
-0.017112918,
0.0103663495,
-0.0049603153,
-0.007043715,
-0.033874664,
-0.0052034347,
-0.01795033,
-0.042816065,
-0.0023417145,
0.0002716102,
0.009738291,
-0.007665021,
-0.009819331,
0.0029647085,
-0.012730013,
0.001721253,
0.014384577,
0.006695919,
-0.0058044805,
0.019557621,
0.008981919,
-0.0059057805,
-0.0101840105,
0.01835553,
0.008083727,
-0.000056295274,
0.011838574,
-0.018423064,
0.041546438,
-0.0016233298,
0.008907632,
-0.014303537,
-0.042518917,
-0.030741123,
-0.0059463005,
-0.0156542,
-0.0030862682,
0.00401485,
-0.009967904,
0.08352509,
0.011413115,
-0.017045386,
0.0015245625,
-0.01932801,
0.027540049,
0.017180452,
0.0027131473,
0.0033141929,
-0.017099412,
0.023609614,
-0.018301504,
0.00617929,
-0.04516622,
0.0024126244,
0.015708229,
-0.008103987,
-0.0023062595,
-0.01618096,
-0.015167962,
-0.004605766,
0.0052473317,
-0.010096217,
0.014114444,
-0.030849177,
0.0036535475,
0.03055203,
0.01254092,
0.016775252,
-0.033604532,
-0.0016950839,
-0.00310484,
-0.05197357,
-0.015789269,
0.022407524,
0.0010847524,
-0.009866604,
-0.021354005,
0.014668216,
0.031254377,
-0.011568441,
0.026918743,
-0.019679181,
-0.0009707901,
-0.00794866,
-0.025676131,
-0.0038392637,
-0.025770677,
-0.0052844747
] |
CONTEXT Overweight and obesity are increasing in the United States. Changes in diet and physical activity are important for weight control. OBJECTIVES To examine the prevalence of attempting to lose or to maintain weight and to describe weight control strategies among US adults. DESIGN The Behavioral Risk Factor Surveillance System, a random-digit telephone survey conducted in 1996 by state health departments. Setting The 49 states (and the District of Columbia) that participated in the survey. PARTICIPANTS Adults aged 18 years and older (N = 107 804). MAIN OUTCOME MEASURES Reported current weights and goal weights, prevalence of weight loss or maintenance attempts, | [
-0.006282725,
-0.015715064,
0.016560245,
-0.033516668,
0.0041796793,
0.008154666,
0.005358309,
0.010419484,
-0.008669698,
-0.017101688,
-0.003720773,
0.010366661,
-0.0070717796,
0.023004742,
-0.016705511,
0.0057412814,
0.03805951,
-0.020020202,
0.0027765483,
-0.01719413,
-0.0373728,
0.0037768981,
-0.0101289535,
-0.004955528,
-0.025342194,
-0.0027022648,
0.03055854,
-0.02190865,
0.013205937,
-0.022067122,
0.0061242534,
-0.013443644,
-0.014579355,
-0.008524433,
-0.016388569,
-0.011106193,
-0.0102081895,
-0.029105885,
0.02915871,
-0.037584096,
0.005038065,
0.0057181707,
-0.011112796,
0.003928766,
0.0039815903,
0.019188227,
0.00089717837,
0.0044074818,
0.0016540437,
0.026121344,
-0.0048894985,
0.018316636,
-0.027177818,
0.004077333,
0.0061803786,
0.004239106,
-0.011740078,
0.03494291,
0.009244156,
-0.05467258,
-0.0023638627,
-0.00044404966,
-0.02642508,
-0.0020271114,
-0.002022159,
0.0014551292,
-0.011984388,
0.017379014,
0.018963726,
0.019769289,
0.016375363,
0.037980277,
0.0004943973,
0.013536085,
0.0014386218,
-0.005417736,
0.012519228,
0.018924108,
0.008438594,
0.011119399,
0.015398123,
-0.0024430985,
-0.00869611,
0.030690597,
0.007771694,
0.022912301,
0.002784802,
0.0120108,
0.0041070464,
-0.016098037,
-0.02704576,
0.004110348,
0.008339549,
0.02324245,
0.00045601753,
0.01043269,
-0.01225511,
0.015649036,
-0.008148063,
-0.0028343243,
-0.009772394,
-0.0034137347,
-0.009488466,
-0.010571353,
-0.021354001,
0.0038957514,
-0.033886436,
-0.0076198257,
-0.0070981914,
-0.02317642,
-0.014777444,
0.029264357,
-0.01508118,
-0.014513325,
-0.013219143,
-0.0068472787,
-0.016718717,
0.0090460675,
-0.01719413,
-0.03251302,
0.019399522,
0.017656337,
0.031615015,
0.020878587,
-0.004027811,
-0.015781095,
-0.036712505,
-0.0050281608,
-0.009963879,
0.008240505,
-0.010795854,
0.009521481,
0.013853028,
0.0037868025,
-0.026543934,
0.01514721,
-0.0008649889,
-0.0050083515,
-0.03573527,
-0.01839587,
-0.007164221,
0.019531582,
-0.021235147,
-0.018052517,
-0.0003357197,
0.027573997,
0.03832363,
0.030769834,
-0.010809059,
-0.015305681,
-0.014935915,
0.0007131206,
0.037953865,
0.014856679,
0.012479611,
0.023295274,
0.008181078,
0.039829105,
-0.025091281,
-0.010478911,
-0.008398976,
0.0070387647,
0.01943914,
0.009481863,
-0.02155209,
0.010241204,
0.0019000042,
-0.01586033,
0.005325294,
0.0003386085,
0.008293329,
0.03214325,
-0.02028432,
0.0076858555,
-0.01832984,
0.0024001792,
-0.018237399,
0.005232853,
-0.025144104,
-0.004103745,
-0.020429585,
0.029792594,
0.027494762,
0.03467879,
-0.0014543039,
0.008623477,
0.029660536,
-0.015556594,
0.010049718,
-0.018607166,
0.011185429,
0.02613455,
-0.016018802,
-0.010591161,
-0.6507886,
-0.0015954423,
-0.0026609963,
0.005962481,
0.010584558,
0.0057511856,
0.0146321785,
0.0047079166,
-0.013588909,
0.030928304,
0.00069826393,
-0.0008183554,
0.006626079,
-0.034969322,
0.0010952675,
0.0009491767,
-0.0186864,
-0.015543388,
0.0039650826,
-0.02760041,
-0.025606312,
0.03919522,
-0.022833066,
0.03383361,
0.0112184435,
0.026477905,
-0.006926514,
-0.011680651,
0.013760586,
-0.0009070828,
0.020522026,
0.017643131,
0.016098037,
0.020931412,
0.043790888,
-0.01761672,
-0.023704657,
0.012697509,
0.01074303,
0.01881846,
-0.0072764712,
-0.0269137,
0.042760827,
0.005232853,
-0.0038924501,
0.009679952,
0.00050347636,
0.015543388,
0.031588603,
-0.012882392,
0.018475106,
0.024008393,
-0.008299932,
-0.013172923,
0.04973356,
-0.004909307,
0.02600249,
-0.015543388,
0.011284473,
-0.01781481,
-0.018012898,
0.009211142,
-0.024285719,
-0.014592561,
-0.034176964,
0.030083125,
-0.010756236,
0.028973827,
0.0037603907,
-0.0040938407,
0.0024612565,
0.03182631,
-0.017894045,
0.003311389,
0.026794847,
-0.008154666,
0.01563583,
0.015437741,
-0.016296126,
0.0134700565,
0.008847978,
-0.0005311263,
0.0013692906,
0.022502918,
0.011112796,
-0.014275618,
-0.009944071,
0.00052988826,
0.0010077781,
-0.0045428425,
0.017854428,
-0.006688807,
-0.01972967,
-0.00516022,
-0.0010911406,
0.0092771705,
-0.009039464,
-0.015318887,
0.032988433,
0.01761672,
-0.032222487,
0.011786299,
0.005084286,
0.014500119,
0.03589374,
0.016890394,
-0.018250605,
0.03887828,
0.057577886,
-0.009871438,
0.028656883,
-0.0040179063,
-0.03055854,
0.010043115,
0.0097856,
-0.034309026,
0.02330848,
-0.017339395,
-0.010353454,
-0.00693972,
0.022885889,
0.009448848,
0.020812558,
-0.026213786,
0.00509419,
0.02775888,
0.0017448345,
-0.002778199,
-0.0003212757,
-0.025540283,
0.00011163144,
-0.0020782843,
0.022450093,
0.0021921855,
0.02464228,
0.011601415,
-0.0030868878,
-0.010010101,
0.0020848874,
-0.014288824,
-0.014658591,
-0.016032008,
0.012506023,
-0.03198478,
-0.0045626513,
-0.027811704,
0.015675448,
-0.005440846,
0.0049885428,
-0.007903754,
0.0076726493,
-0.029766183,
-0.022502918,
-0.002849181,
-0.009382819,
-0.020271113,
-0.0063553574,
-0.026028903,
0.010901501,
0.012506023,
-0.0034797646,
-0.0036415372,
-0.012109845,
-0.0133908205,
0.018858079,
-0.0059261643,
-0.011872138,
0.009620525,
-0.0074349428,
-0.029317182,
0.0100563215,
-0.018078929,
-0.017220542,
0.026808053,
-0.0016334094,
0.01810534,
-0.026583552,
0.0014939216,
0.0025206832,
-0.005754487,
0.016705511,
0.017960075,
-0.04453042,
0.0044008787,
0.009151715,
-0.004975337,
0.0068670874,
0.0028722913,
-0.0028211183,
0.02077294,
-0.009594114,
0.010551544,
-0.00971957,
0.021169117,
0.013826616,
-0.0052592647,
-0.0070453677,
-0.01570186,
0.022859478,
0.021208735,
0.03267149,
-0.00013020229,
0.017220542,
-0.012869186,
0.019016549,
-0.007217045,
0.01654704,
-0.008722521,
0.015583006,
0.0012628178,
-0.0024942714,
0.00088314706,
-0.0074547515,
-0.005331897,
-0.009303583,
0.030268008,
-0.00438107,
0.021340795,
-0.006787852,
0.002682456,
-0.016150862,
-0.030268008,
0.023546185,
-0.017299779,
-0.025500664,
0.023559391,
-0.00026019823,
0.018475106,
-0.0018224193,
0.009191332,
-0.0084980205,
-0.007864135,
-0.0025454445,
0.007401928,
-0.003974987,
-0.018144958,
0.008933817,
-0.026491111,
0.0224633,
0.03819157,
0.020139053,
0.0035160808,
0.035444736,
-0.0029531778,
0.00042754223,
-0.009237553,
0.03256584,
0.022661388,
-0.019254256,
-0.004041017,
0.0056818547,
-0.004176378,
-0.013331394,
0.0014543039,
-0.0015310633,
0.00034892562,
0.013905852,
-0.011555195,
0.024048012,
0.027547585,
0.032882784,
0.024589455,
0.0008649889,
0.014751032,
0.013120099,
-0.018237399,
-0.007844327,
-0.00014433677,
-0.004539541,
-0.003443448,
-0.028656883,
-0.035603207,
0.016692305,
-0.026649581,
0.022502918,
0.016388569,
0.011053369,
-0.011555195,
0.022304827,
0.022278417,
-0.020165466,
-0.0010754585,
-0.00006659713,
0.024959221,
0.013463453,
0.00025462697,
0.0063850707,
0.0061737755,
-0.01648101,
0.022357652,
0.014222794,
0.017629927,
-0.018792048,
-0.017273366,
-0.011845726,
0.028498413,
0.019637229,
-0.01859396,
0.010703412,
-0.0016210288,
0.023321684,
-0.010221396,
-0.012737126,
-0.020323938,
0.032724313,
-0.0018570849,
-0.00009342169,
-0.021618119,
-0.009633731,
-0.009283774,
-0.005487067,
-0.012657891,
-0.0066623953,
0.035391912,
-0.006573255,
0.0029944463,
-0.0025322384,
-0.0036019194,
0.01285598,
-0.010624177,
-0.0032040905,
-0.03510138,
-0.020442791,
-0.01741863,
0.07300242,
0.009019655,
0.0024876685,
0.015530182,
-0.004942322,
0.02473472,
-0.005929466,
-0.017114894,
-0.0029416226,
0.012796553,
0.0031149504,
0.014949121,
0.010518529,
-0.006061525,
0.0041631716,
0.0035127793,
0.022252005,
-0.03903675,
-0.011026958,
0.011007149,
-0.015926361,
0.013800205,
0.034890085,
0.04690749,
0.013971882,
-0.005770995,
-0.013417232,
0.052480396,
-0.014618972,
-0.012882392,
-0.018884491,
0.006959529,
-0.00052947557,
0.039538577,
-0.010478911,
0.020231497,
0.0065600495,
0.016745128,
0.018118545,
-0.0023770686,
0.046379253,
-0.007580208,
0.002132759,
0.0030967924,
-0.0006904229,
-0.019399522,
0.011000546,
0.050948504,
0.0068736905,
-0.008544241,
0.010868486,
-0.0046749017,
-0.0171281,
-0.02889459,
0.004390974,
-0.021433236,
0.003988193,
-0.0155698005,
-0.019940965,
-0.033622317,
-0.01612445,
-0.013503071,
0.019267462,
-0.0039155604,
-0.008260313,
-0.025170516,
-0.020271113,
-0.01839587,
-0.010478911,
0.015424535,
0.0155698005,
-0.012994642,
0.010373264,
0.025896844,
-0.0009359708,
-0.00029053062,
0.024972428,
-0.01774878,
0.012096639,
0.019888142,
-0.0077056643,
0.00464849,
-0.0057643917,
-0.01648101,
0.0002571031,
0.0026296324,
-0.0016854077,
-0.019769289,
-0.021789797,
0.014764238,
-0.04254953,
-0.008187681,
0.019056167,
-0.008306535,
-0.013681351,
-0.0224633,
0.0032156457,
0.013905852,
0.004176378,
-0.012043815,
0.01514721,
-0.004744233,
-0.01321254,
-0.019042961,
0.027917352,
0.0035160808,
0.00030930783,
-0.01839587,
-0.007157618,
-0.018937314,
0.010016703,
-0.0063289455,
0.0022747228,
-0.0019940964,
0.022502918,
0.015979184,
0.008108445,
0.03127166,
0.015662242,
-0.016322538,
-0.000612838,
-0.01341063,
0.012915406,
0.014328442,
-0.04479454,
0.0038297218,
-0.017722368,
0.0029630822,
-0.05551776,
-0.008795154,
0.0039716857,
0.016520627,
-0.0139322635,
-0.049839206,
-0.034599558,
0.0020980933,
-0.010412881,
0.01726016,
-0.0141699705,
-0.020654086,
-0.028551236,
-0.013971882,
0.010643985,
-0.015318887,
0.048782732,
-0.028815355,
0.017880838,
-0.0031776787,
-0.02346695,
0.028841767,
0.0012958326,
-0.0010894898,
-0.0053054853,
0.007157618,
-0.0020155562,
-0.03058495,
-0.019491963,
0.0022450094,
0.042496707,
0.009679952,
0.006952926,
0.020706909,
-0.0036151253,
0.0068076607,
0.0031446638,
-0.008154666,
-0.007547193,
-0.00060912385,
-0.012591861,
-0.0001611537,
0.010069527,
0.01794687,
0.000019628356,
0.010927913,
0.027864527,
-0.020033406,
0.0041532675,
-0.0145529425,
-0.040066812,
-0.0045428425,
0.008220696,
-0.016784746,
-0.0015285872,
0.02064088,
-0.060536016,
-0.018012898,
0.017603515,
0.026081726,
0.0012165969,
0.018924108,
-0.00616057,
-0.03029442,
0.01230133,
-0.0024232895,
-0.027679645,
-0.009759188,
-0.024497014,
-0.020720115,
-0.00078657863,
0.013694557,
-0.011872138,
0.0028326735,
-0.013919058,
-0.010809059,
-0.020971028,
0.0053451033,
-0.029317182,
-0.010492117,
0.0072962805,
-0.021538883,
0.0004168124,
0.0024166866,
-0.009871438,
-0.010135557,
-0.02021829,
0.018343046,
-0.018620372,
0.02684767,
0.0013337997,
-0.02255574,
-0.025923256,
-0.00008774726,
0.023348097,
0.00947526,
0.034203377,
0.0109081045,
-0.015239651,
-0.027494762,
-0.0002866101,
-0.0036514418,
0.0030208582,
0.024813956,
-0.010016703,
0.0013899249,
-0.00074365933,
-0.006018606,
0.005100793,
-0.018937314,
-0.041466642,
0.0030175566,
0.014711414,
0.0030868878,
0.00431504,
0.0076198257,
-0.021750178,
0.032777138,
-0.0034038303,
-0.018290224,
0.019201433,
-0.02142003,
0.0015657289,
0.029977478,
-0.033516668,
-0.0013610369,
-0.0050050505,
-0.010538338,
0.0019148609,
-0.027230643,
-0.0058172154,
0.012169271,
0.010683604,
-0.0021888842,
-0.012248507,
0.0008109271,
0.010927913,
0.010333646,
-0.010102542,
0.0037273758,
-0.016943218,
0.030901894,
-0.003918862,
-0.029317182,
-0.00602851,
-0.0022351048,
0.013971882,
0.027362702,
-0.019954171,
-0.027653232,
-0.0073953248,
-0.0036580446,
0.03127166,
0.0106770005,
-0.030981129,
0.011251459,
-0.012717318,
-0.019135403,
-0.010062925,
-0.019518375,
0.00089965446,
-0.012314537,
-0.023968777,
-0.018871285,
-0.020482408,
0.02860406,
0.016969629,
-0.012796553,
0.0054210373,
0.01908258,
-0.031931955,
0.0197957,
-0.010294029,
0.016626274,
-0.025527077,
0.037240744,
-0.031879134,
-0.016705511,
0.011872138,
0.016401773,
-0.03338461,
-0.047673434,
0.0040113037,
0.006530336,
0.0011728524,
0.00026556314,
-0.0037570891,
0.006332247,
0.018422283,
-0.019425934,
-0.017669544,
0.028498413,
-0.011198635,
0.02577799,
0.027230643,
-0.0010399675,
0.022093533,
-0.0036217284,
0.019676847,
0.009112096,
-0.024959221,
0.0031710756,
-0.031615015,
0.039063163,
-0.026530728,
0.017339395,
-0.010809059,
0.010426087,
0.0005711568,
0.028498413,
0.0014889694,
-0.02164453,
-0.0028194676,
0.0035953163,
0.011594813,
0.004780549,
-0.021935062,
-0.007210442,
-0.016058419,
0.002906957,
-0.04017246,
-0.00838577,
0.0010506974,
0.0389311,
0.021763384,
-0.010003498,
-0.014156764,
-0.006216695,
-0.037108682,
0.006018606,
0.020522026,
0.021089882,
-0.015622624,
-0.000019383324,
0.016098037,
0.000089655936,
0.007137809,
0.026160961,
-0.020852175,
-0.020720115,
0.012862583,
-0.007613223,
-0.002873942,
-0.0028722913,
-0.0242461,
0.0062530115,
0.003489669,
-0.028551236,
-0.005978988,
0.014896297,
0.00736231,
0.00032787866,
-0.014922709,
-0.005292279,
-0.004001399,
-0.015965978,
0.02242368,
-0.014262413,
0.016943218,
0.00025648405,
0.007018956,
0.01116562,
-0.029317182,
0.0044272905,
-0.014037912,
0.012208889,
-0.033727963,
-0.022648182,
0.0019429235,
-0.027547585,
0.008709315,
0.0012685953,
0.006639285,
0.01232114,
-0.016322538,
0.0054705595,
-0.014460501,
0.0017828016,
-0.021235147,
0.0020320637,
0.010993943,
-0.011059972,
0.00025256356,
-0.007798106,
-0.001901655,
0.0014551292,
0.02421969,
-0.011271267,
-0.0072368537,
-0.03383361,
0.005655443,
0.0029746373,
-0.007210442,
-0.0026742022,
0.004919212,
-0.022476505,
0.015437741,
-0.028841767,
0.014447295,
-0.030215185,
0.014183177,
0.0070453677,
-0.015965978,
0.029422829,
0.019676847,
-0.026477905,
0.010333646,
0.034599558,
0.20358273,
-0.017458249,
0.009462054,
0.031641427,
0.00338072,
0.034916498,
0.040964816,
0.01341063,
-0.014473707,
0.012162669,
-0.008306535,
0.0064643063,
-0.015622624,
0.011674048,
0.017933663,
0.003796707,
-0.030083125,
-0.0018521327,
0.026108138,
-0.0024629072,
-0.008108445,
-0.024298925,
-0.010769442,
-0.010340249,
0.04196847,
0.01314651,
-0.0073292954,
0.01986173,
0.017656337,
-0.0033460543,
-0.01634895,
-0.017669544,
0.010102542,
0.016758334,
-0.007969784,
0.004935719,
-0.003988193,
0.0038000084,
0.004341452,
-0.0129286125,
0.03774257,
-0.013087084,
0.0009326693,
-0.014288824,
0.0011167271,
0.0072236476,
0.0014006547,
-0.0026230293,
-0.0049324175,
-0.021327589,
-0.022582153,
-0.0005274121,
0.014830268,
0.025328988,
-0.010795854,
0.018290224,
0.03589374,
0.0008047368,
-0.011535387,
0.0006962005,
-0.0030241597,
0.011482563,
-0.021578502,
0.026451493,
-0.002035365,
0.032380957,
0.008055622,
0.0093432,
-0.010947722,
-0.017973281,
0.01387944,
-0.004731027,
-0.019161815,
0.00034913197,
-0.01098734,
-0.008220696,
0.017101688,
0.011852329,
0.009911056,
0.013853028,
-0.03169425,
-0.028498413,
0.010531735,
0.01930708,
-0.009554496,
-0.016494216,
0.01752428,
0.0066855056,
0.0040311124,
-0.013668145,
-0.0014377964,
-0.0004770645,
-0.01109959,
0.0016713764,
0.0045527467,
-0.020495614,
-0.014447295,
-0.00032333913,
-0.013575704,
-0.020442791,
-0.017352602,
0.0749569,
-0.0050545726,
0.009032861,
0.019874936,
-0.029317182,
-0.013285173,
0.012638082,
0.007144412,
-0.008550844,
0.014090735,
-0.04466248,
0.016098037,
-0.012446596,
0.0009557797,
-0.000633885,
0.015899949,
-0.007633032,
-0.009501672,
-0.0438173,
-0.0024695103,
-0.023810305,
0.022767035,
0.029502064,
-0.015741477,
0.0039155604,
0.012109845,
-0.023929158,
-0.012922009,
-0.012129653,
0.0037603907,
-0.016401773,
-0.018197782,
-0.024285719,
-0.011773093,
-0.016863981,
-0.0023027854,
0.0010201586,
-0.020482408,
0.0037174714,
-0.010109145,
-0.010485514,
-0.0067449324,
0.010214793,
0.020588057,
-0.036580447,
-0.01236736,
0.020627674,
-0.000057466463,
0.0043315473,
-0.0074283397,
0.008088636,
-0.008524433,
0.0058832453,
0.027864527,
-0.012235301,
0.006705315,
-0.020006996,
-0.005024859,
0.01508118,
-0.017431837,
0.0029729865,
0.029475652,
-0.007593414,
0.0024629072,
0.008861184,
-0.16745129,
0.029898241,
0.023797099,
-0.020706909,
0.011132605,
-0.023216037,
0.017537484,
0.0021492662,
-0.013040863,
0.012988039,
0.03370155,
0.006266217,
-0.025038457,
-0.016705511,
-0.0037868025,
-0.013225746,
-0.000027314623,
0.019544788,
0.021433236,
0.024351748,
0.011601415,
0.012162669,
-0.017577102,
-0.001056475,
-0.008313137,
0.027415525,
-0.0036580446,
0.034995735,
0.0033774185,
-0.022344446,
-0.01443409,
0.020812558,
0.010445897,
0.012532434,
-0.027679645,
0.0012570402,
-0.010842075,
-0.0062629157,
-0.00053938,
0.0242461,
0.022027504,
0.034995735,
0.009415833,
0.011139208,
-0.0019825413,
0.01803931,
0.009079082,
-0.0035424926,
-0.0031578697,
-0.0057016634,
-0.00021913603,
-0.024074424,
-0.0002721661,
-0.0075273844,
-0.00754059,
0.0024117343,
0.0031066968,
0.010848678,
0.0048762923,
-0.00066318567,
0.0005224599,
-0.013786999,
0.012545641,
0.018092135,
-0.021354001,
-0.015239651,
-0.028075824,
-0.008504624,
-0.013773792,
-0.014381265,
-0.014909503,
-0.004275422,
-0.01285598,
-0.0070717796,
0.032750726,
0.03562962,
-0.008914008,
-0.0019544787,
0.000021575715,
-0.0033642126,
0.0014840172,
-0.014909503,
-0.030479303,
-0.0005728075,
0.011865535,
0.022925507,
0.014117147,
0.014935915,
0.022634977,
-0.017629927,
0.010868486,
-0.026874082,
0.009178126,
-0.012274919,
-0.0021079977,
0.017484661,
0.00063223427,
0.014420884,
0.024813956,
-0.00916492,
-0.002631283,
-0.012552244,
-0.025474252,
0.014737826,
-0.0017464852,
-0.01755069,
-0.007778297,
0.009138509,
0.026900494,
-0.0028194676,
-0.017722368,
0.012466405,
-0.005457354,
0.014051117,
0.01121184,
0.01232114,
0.012869186,
-0.012697509,
0.0027699454,
-0.009917659,
0.037425626,
0.0036085225,
-0.022225592,
0.021248354,
-0.0034665586,
-0.005896451,
-0.105436206,
-0.027943764,
0.01225511,
0.012083433,
0.012572052,
0.023532981,
-0.019940965,
0.0029812404,
-0.0072962805,
0.03858775,
-0.017431837,
-0.017854428,
-0.016032008,
-0.0061572683,
0.021816209,
-0.00020964425,
0.0056422367,
-0.028788943,
-0.0032222487,
0.044266302,
0.0129286125,
-0.031218836,
-0.0015979185,
-0.023057567,
-0.02555349,
-0.0061110477,
-0.01832984,
0.0029993986,
-0.01154199,
-0.0019445743,
-0.00558281,
0.0034731615,
0.022806654,
0.009429039,
-0.02050882,
0.007177427,
-0.031245248,
-0.005596016,
0.017841222,
-0.018514724,
0.0038132144,
-0.009290377,
0.008920611,
-0.021050263,
-0.008121652,
-0.019346697,
-0.0023027854,
-0.019346697,
-0.0026098234,
-0.01859396,
0.008940419,
-0.032196075,
-0.012697509,
-0.013971882,
-0.037848216,
-0.02077294,
0.0006619476,
-0.0023985284,
0.0131597165,
0.006523733,
0.005232853,
0.0342562,
-0.030400068,
0.02086538,
0.021169117,
0.0040113037,
-0.014209589,
-0.009415833,
-0.0025503966,
-0.011641034,
-0.031086776,
0.023519775,
-0.00851783,
0.031852722,
-0.01121184,
-0.006457703,
-0.026491111,
-0.016190479,
0.0041004433,
-0.02642508,
-0.020601261,
-0.012136256,
0.00018570849,
-0.0142492065,
0.0066921087,
-0.010888295,
0.003443448,
-0.006484115,
-0.0017596912,
-0.024391366,
0.009396024,
0.031033952,
0.026160961,
-0.016296126,
0.0054210373,
0.010426087,
0.00037678189,
0.004681505,
0.00059756864,
-0.0074547515,
-0.021354001,
-0.0012941818,
-0.054725405,
0.022410475,
0.019280668,
-0.010412881,
-0.030083125,
0.0015145559,
0.003879244,
-0.021023853,
0.0009194634,
0.024298925,
0.00024018298,
0.03747845,
-0.0009797155,
-0.01654704,
-0.041757174,
-0.029819006,
0.018277017,
0.010531735,
0.02473472,
0.0322489,
0.0014699859,
0.023136802,
0.021578502,
0.005176727,
0.002375418,
0.017577102,
-0.01303426,
0.023915952,
0.0010713317,
0.00047293762,
-0.0027418828,
-0.022001091,
-0.01147596,
0.012354154,
-0.015609418,
-0.033754375,
0.010346852,
0.018620372,
0.02655714,
0.009547893,
0.02028432,
-0.016560245,
0.005166823,
-0.017854428,
-0.007639635,
0.0055200816,
-0.011799505,
-0.014949121,
0.005242757,
-0.017299779,
0.012664494,
0.022133151,
0.009316789,
-0.025276164,
-0.01895052,
-0.0043315473,
0.0022615169,
0.010511926,
-0.013707763,
-0.024391366,
0.014130353,
-0.010531735,
0.008425388,
0.0051503154,
-0.011092987,
-0.0145529425,
0.0016235049,
-0.0063883723,
-0.013773792,
-0.03169425,
0.016956424,
0.019003345,
-0.0030390164,
-0.01205702,
-0.0096667465,
-0.0025702056,
-0.036421973,
0.02775888,
-0.0083461525,
0.019412728,
0.014539737,
0.010663794,
-0.014817062,
0.017431837,
0.02915871,
0.00021583455,
-0.035259854,
-0.00029445114,
-0.0044768127,
-0.0074811634,
-0.033146903,
0.014222794,
0.0037438832,
-0.0057346784,
0.0045098276,
0.011258062,
0.01038647,
-0.005665347,
0.0033146902,
0.015675448,
0.018356252,
0.0015483962,
-0.035867326,
-0.037821803,
-0.0070651765,
-0.010168572,
0.013641734,
-0.032750726,
-0.029819006,
0.0126777,
0.004879594,
0.03409773,
-0.008960228,
0.0025074773,
0.013641734,
0.019808905,
-0.027257055,
-0.008788551,
-0.009059273,
0.011614622,
0.01032044,
0.01572827,
-0.00916492,
-0.012585258,
0.0119183585,
0.016679099,
0.019399522,
-0.0032238995,
-0.009389421,
-0.0022169468,
0.008359359,
-0.013919058,
-0.025249751,
-0.017154513,
0.012836171,
-0.02760041,
0.010010101,
-0.0020271114,
-0.0065534464,
0.06212073,
0.0031413625,
0.0036580446,
0.0033344992,
0.010584558,
0.0029630822,
0.019095786,
0.01140993,
-0.02050882,
0.009772394,
0.024721514,
-0.0116872545,
-0.007342501,
-0.039406516,
-0.013371011,
0.03565603,
0.0030192074,
-0.003311389,
-0.001370116,
-0.0008063876,
0.009468657,
-0.021525677,
0.017180925,
-0.012882392,
-0.016665893,
-0.022634977,
0.016296126,
0.0030109538,
-0.017603515,
-0.025593106,
0.0043678638,
0.0123079335,
-0.015503771,
0.0051635215,
0.03763692,
-0.01586033,
-0.009112096,
-0.0014972232,
0.000896353,
-0.009336597,
0.018514724,
0.020297525,
-0.014275618,
0.0009037813,
-0.023493363,
0.0058832453,
0.0026560442,
-0.0121494625,
-0.044451185
] |
Epstein-Barr virus (EBV) is associated with multiple sclerosis (MS), and antibodies to the EBV nuclear antigen-1 (EBNA-1) are consistently increased in MS patients. The hypothesis of this study is that anti-EBNA-1 antibodies cross-react with a self antigen in MS patients. We affinity purified anti-EBNA-1 antibodies from human plasma, used the anti-EBNA-1 to immunoprecipitate antigens from human brain, and identified bound antigens with mass spectrometry. Anti-EBNA-1 consistently bound heterogeneous nuclear ribonucleoprotein L (HNR | [
-0.038676187,
-0.014434553,
-0.01136491,
-0.030762162,
-0.025437942,
-0.006145859,
-0.014460845,
-0.011989355,
-0.026200423,
-0.0038945684,
-0.013619487,
-0.003117298,
0.0023498873,
0.004058896,
-0.017313575,
0.0014222569,
0.027212681,
0.018049764,
-0.0030334909,
-0.006546819,
-0.03331253,
0.004157493,
0.012883298,
-0.027370436,
-0.007039802,
0.0125480695,
0.0048805354,
-0.05558223,
-0.016958628,
-0.0050251437,
0.024228489,
-0.019390678,
-0.011969636,
-0.00198015,
0.014592308,
-0.030578114,
-0.0018125355,
0.005879648,
0.038334385,
0.02839584,
0.011483226,
0.0032651932,
-0.012883298,
0.01736616,
0.009215502,
0.013632633,
-0.008880273,
-0.0046274704,
-0.018194372,
0.037598196,
0.031892736,
-0.0060078236,
-0.00003576697,
0.011358337,
-0.019482702,
-0.020468669,
-0.0007871301,
0.009642755,
0.0013244819,
-0.018509882,
-0.01077333,
0.0005504981,
-0.029316077,
0.0029940524,
-0.009879386,
0.010641867,
-0.0044795754,
0.001046768,
-0.0057284664,
0.010030568,
0.0337595,
0.0070595215,
-0.030578114,
0.008466167,
0.021296881,
0.0006162292,
-0.01712953,
-0.018549321,
0.016038392,
-0.005242056,
0.036835715,
-0.017168967,
-0.009669047,
0.00503829,
0.0072830073,
-0.0013458446,
-0.011443787,
0.0010870283,
0.01747133,
-0.0047162073,
0.0063364794,
0.023058474,
0.017076943,
-0.017458184,
0.0011913765,
0.032734096,
0.007822002,
0.026857734,
-0.006119567,
-0.017931448,
-0.004357973,
0.0011108558,
-0.015657151,
-0.008913139,
-0.0074670548,
0.003395012,
-0.0077496986,
0.0024895659,
-0.016590534,
-0.004680055,
-0.018417858,
0.016551094,
-0.0070463754,
-0.038860235,
0.018115494,
0.017392453,
0.025924351,
-0.026476493,
-0.009912252,
0.0042593763,
-0.0062641753,
0.026108399,
0.0073421653,
-0.030656992,
0.023124207,
0.025503673,
-0.046616506,
-0.014710624,
-0.009590169,
-0.000036203466,
0.012699251,
0.031130256,
0.005597004,
0.0010862066,
-0.013803534,
0.011614688,
-0.021664975,
-0.01747133,
-0.020784179,
-0.019995404,
0.0130081875,
0.024530852,
-0.0014206137,
-0.014920963,
-0.004121341,
0.014066459,
0.013856119,
0.02251948,
0.026686832,
-0.008617349,
-0.036914594,
-0.030709576,
0.022874428,
-0.017313575,
-0.004808231,
0.011062547,
-0.016314462,
0.03999081,
-0.03141947,
-0.02794887,
-0.014316237,
-0.004328394,
0.018956853,
-0.0011313969,
-0.0060406895,
0.03978047,
-0.033785794,
-0.01833898,
-0.0033391407,
-0.03170869,
-0.007296154,
0.04064812,
-0.039727885,
-0.0070595215,
0.00385513,
0.008216389,
0.0026538938,
0.008420155,
-0.016761433,
-0.023623763,
0.008262401,
0.023847248,
0.033917256,
-0.021007665,
-0.0035396204,
0.004666909,
0.034863785,
-0.020823617,
0.0073750312,
-0.011207155,
-0.0022315714,
0.015407373,
0.0037565331,
-0.04645875,
-0.6289153,
-0.030288897,
0.022637796,
0.0015685087,
0.00771026,
0.020284621,
0.008328132,
0.0028116484,
-0.0049429797,
0.023295106,
-0.049193166,
0.016695702,
0.00045765287,
0.0047622193,
0.0024616302,
-0.023676347,
-0.010168604,
-0.0028461572,
0.038229216,
-0.0067440122,
-0.019009437,
-0.0017320148,
-0.0031435906,
0.012212841,
-0.0056134374,
-0.010181749,
-0.011877612,
-0.011936771,
0.005074442,
0.031524643,
-0.018286396,
0.05063925,
0.010405235,
0.004262663,
0.040043395,
-0.016196147,
-0.011509518,
0.0175765,
0.008709373,
0.031472057,
-0.008499033,
-0.010595855,
-0.0023679633,
-0.028185502,
-0.0026670399,
0.04088475,
-0.009011736,
0.021099688,
0.00043177124,
-0.016577387,
0.01413219,
0.027133804,
-0.02262465,
-0.0011601541,
0.013238247,
0.008295267,
0.009116906,
-0.025280187,
0.011680419,
-0.006842609,
-0.004831237,
-0.0041147675,
0.0049298336,
-0.027685946,
-0.022664089,
-0.026897172,
-0.02460973,
0.00878825,
0.016998066,
-0.006954352,
0.029684171,
0.01983765,
0.006339766,
0.009445561,
0.02279555,
0.025832327,
-0.0037335274,
0.0086765075,
-0.03964901,
-0.0040490367,
-0.025135579,
-0.014368822,
-0.025529964,
0.0037236677,
0.01795774,
-0.008314986,
-0.008913139,
0.019114608,
0.00063019706,
0.009399549,
-0.0056528756,
0.0051303133,
-0.006063695,
-0.023584323,
-0.02300589,
0.014105897,
-0.012035367,
0.014289944,
0.01311993,
0.005951952,
-0.007381604,
-0.01590693,
0.015223326,
-0.022177678,
0.021086542,
0.0013113357,
-0.019982258,
0.0248858,
0.044539403,
-0.013014761,
0.0005061296,
0.0038288373,
0.0060834144,
-0.0077431253,
0.017142674,
-0.018404713,
-0.006267462,
-0.00081342255,
-0.017142674,
-0.023058474,
0.0051270267,
0.006208304,
-0.00749992,
-0.012423181,
-0.004252803,
0.015302204,
-0.005695601,
-0.0118381735,
0.006941206,
-0.025661428,
-0.012561216,
0.002614455,
0.010516978,
0.00026723807,
0.032287125,
0.008959151,
0.015565128,
0.015026133,
-0.0149341095,
-0.03439052,
-0.03362804,
-0.023886686,
-0.006244456,
-0.00024505382,
-0.0069214865,
-0.0022775831,
-0.01778684,
0.0008162983,
-0.007138399,
0.023794664,
0.017168967,
0.010793049,
-0.015341642,
0.028316963,
0.016827166,
-0.0025273613,
-0.01924607,
-0.01645907,
0.006901767,
-0.0037959719,
-0.010109445,
0.021862168,
0.009859667,
0.00022759398,
-0.0023203082,
-0.024806922,
0.02262465,
0.023558032,
-0.010609002,
-0.032734096,
0.022059362,
-0.0049068276,
-0.0022036356,
0.01580176,
-0.003697375,
-0.004726067,
-0.017878864,
-0.007979757,
0.00029168182,
-0.008499033,
-0.003980019,
0.009195783,
0.003395012,
-0.013632633,
0.0556874,
0.0072041303,
0.013606341,
0.004164066,
0.026200423,
0.01772111,
-0.0020803898,
0.030367775,
-0.044854913,
0.009491573,
0.014736916,
-0.013001614,
-0.011719857,
-0.0019620738,
0.012600655,
0.018825391,
-0.012009075,
-0.022059362,
0.0059585255,
-0.001738588,
0.02450456,
-0.030262604,
-0.0028461572,
-0.03386467,
0.0013959645,
0.0077431253,
-0.0032849123,
-0.0011124992,
-0.006500807,
-0.0013877482,
-0.011726431,
-0.014395114,
-0.005643016,
0.011121704,
0.0075262124,
-0.00897887,
-0.028316963,
0.028579889,
0.015131302,
0.0013433796,
0.008650214,
0.013349989,
0.013409147,
0.026147837,
0.008328132,
0.007427616,
0.005794198,
0.013290831,
0.036625378,
-0.008709373,
-0.00623131,
0.0056265835,
0.0046734824,
-0.015998954,
0.03462715,
-0.0065073804,
-0.022887575,
0.00041225733,
-0.017839424,
0.02596379,
0.019127754,
-0.02241431,
0.002395899,
0.022992743,
0.011055973,
0.032287125,
-0.032497462,
0.008288694,
-0.007486774,
0.0111742895,
-0.011430641,
0.0039011417,
-0.0060669817,
0.001927565,
0.0438558,
0.020586984,
0.04233084,
-0.0028395841,
0.0042593763,
-0.0012718971,
0.011654126,
-0.017970886,
-0.004890395,
-0.009130051,
-0.0071186796,
0.0053735184,
-0.03744044,
-0.016971774,
0.0153679345,
-0.014842086,
0.0012628591,
0.0017517342,
0.0174056,
0.035836603,
0.031130256,
0.006941206,
-0.026213568,
-0.0155519815,
0.015499397,
0.0037072347,
-0.01924607,
-0.00897887,
0.01639334,
-0.018891122,
-0.0042922418,
0.006096561,
0.025030408,
0.02063957,
-0.0051237405,
0.01510501,
0.009833375,
-0.009629608,
0.014986694,
-0.010293492,
-0.0035987785,
-0.020166306,
0.0007702865,
-0.021875314,
-0.010023995,
0.006665135,
0.007269861,
-0.006576398,
-0.011739577,
-0.009682193,
0.005376805,
0.002407402,
0.019969113,
-0.00868308,
-0.017839424,
0.023084767,
0.0059683854,
0.029263493,
-0.00016843597,
0.008439875,
0.034548275,
0.014289944,
-0.023742078,
-0.029868219,
-0.01580176,
-0.015144449,
0.028737644,
0.007322446,
-0.028842812,
0.026699979,
0.022374872,
0.01303448,
-0.022874428,
-0.053689174,
0.022742966,
0.00026354069,
-0.01597266,
-0.0007070203,
0.0019209918,
0.0031255146,
0.027659653,
0.022677235,
0.00094324147,
-0.031971615,
0.017418746,
-0.0033095616,
0.013777241,
0.0002154748,
-0.0025766597,
0.043671753,
0.014211067,
-0.002910245,
-0.013382855,
0.0019045591,
0.0045683123,
-0.039833054,
-0.0085844835,
0.028001456,
0.003506755,
0.001768167,
-0.008157231,
-0.03320736,
0.0034147315,
0.03665167,
0.011023108,
0.011410922,
0.02311106,
0.01056299,
0.009964837,
0.0158412,
0.0042790957,
0.016353901,
0.0033785794,
-0.015709735,
0.0036940887,
-0.011621261,
0.017497623,
-0.02467546,
0.006477801,
-0.023360837,
-0.022190824,
0.009300953,
-0.0047983713,
0.0007271505,
-0.017760547,
0.0033046317,
-0.0069937906,
-0.008623922,
0.023189938,
0.002152694,
-0.013159369,
-0.0066158366,
-0.012672959,
-0.012074806,
-0.014986694,
-0.012469192,
0.0041246274,
-0.01768167,
-0.03439052,
0.016735142,
0.011384629,
0.01966675,
0.008899993,
-0.009537585,
0.008321559,
0.011101985,
-0.021796437,
0.004601178,
-0.004571599,
-0.016735142,
-0.0030844326,
0.020192599,
0.028947983,
-0.006536959,
-0.031629812,
-0.014973548,
0.00043752274,
-0.0032027485,
0.015459958,
0.011378055,
0.010319785,
0.0074473354,
0.007368458,
0.030157436,
-0.016485363,
-0.0051664654,
-0.006901767,
-0.027291559,
0.0050645825,
-0.021967338,
0.0033029886,
-0.026884025,
-0.0051960447,
-0.005452396,
-0.012081379,
-0.006540246,
0.00060349377,
-0.011424067,
0.011489799,
0.0012431397,
0.012015647,
0.0072764345,
0.015354788,
0.011042827,
0.009544157,
-0.01768167,
-0.0018601905,
-0.013724657,
0.025884913,
-0.008650214,
0.0066684214,
-0.004016171,
0.007973184,
-0.008847408,
0.0012579293,
-0.02425478,
-0.028869106,
0.03362804,
-0.0029726897,
-0.013961289,
-0.03807146,
-0.008761957,
-0.0058829347,
0.028316963,
0.022111947,
-0.026371323,
0.002164197,
0.020008551,
-0.0063594854,
0.0076182364,
0.018089203,
-0.026476493,
-0.0017451611,
0.042094205,
-0.021244297,
-0.00048723188,
0.0033851524,
-0.0046636225,
0.003293129,
0.017353015,
-0.011095412,
-0.011443787,
0.0016449211,
0.011825028,
0.04921946,
0.022282848,
0.02871135,
-0.0158412,
0.009425842,
0.023216229,
0.0075327856,
0.005991391,
-0.018470444,
0.009254941,
0.002082033,
0.012304865,
0.018049764,
-0.008735665,
0.022256555,
-0.033733208,
0.01510501,
0.020481816,
-0.025806036,
-0.016209293,
-0.011378055,
-0.039622717,
0.020179452,
0.021454636,
-0.012081379,
0.04083217,
-0.039149452,
-0.017760547,
0.012745263,
-0.030735869,
0.005511554,
-0.02084991,
0.012429753,
-0.033496577,
-0.009465281,
0.0009120192,
0.0013729586,
0.0081243655,
0.009425842,
0.0010681306,
-0.02248004,
0.024320513,
0.025608841,
-0.0014091107,
0.010911365,
0.0023843963,
0.015959514,
0.0021543372,
-0.020074282,
-0.01333027,
-0.032523755,
-0.0102343345,
0.0029480404,
-0.026778856,
-0.0316824,
-0.011226875,
0.000017896324,
0.013908704,
0.01677458,
0.0118381735,
-0.009642755,
-0.024281073,
0.016643118,
-0.016827166,
0.026673686,
-0.030919917,
0.020652717,
0.01413219,
-0.004755646,
-0.02397871,
-0.010786476,
0.0015808333,
-0.0003882244,
0.016432779,
0.0362047,
0.00023889152,
-0.021428343,
0.015749175,
0.0032372575,
0.0003547426,
-0.033391405,
0.042751517,
-0.006855755,
0.007355312,
-0.010444674,
-0.029605294,
0.004216651,
0.013343416,
-0.011779016,
-0.01510501,
0.009918825,
-0.014408261,
-0.020245183,
0.012469192,
-0.0158412,
0.0292372,
-0.014460845,
-0.02902686,
-0.013448586,
-0.01736616,
0.0012825783,
-0.014907816,
-0.000017023332,
0.036520205,
0.010102873,
0.008781677,
0.0008471097,
-0.0022019923,
0.0040720426,
0.009070894,
0.0072041303,
0.031445764,
-0.0018815531,
-0.007782564,
0.0023679633,
0.02245375,
0.029736755,
0.007079241,
-0.012219414,
-0.008755384,
-0.015354788,
0.005399811,
0.022979598,
0.0059453794,
-0.018825391,
0.014408261,
-0.016866604,
-0.001647386,
-0.028159209,
-0.019758772,
0.0032060351,
-0.062418267,
-0.0029283212,
0.0021148985,
0.010227761,
0.024044441,
0.0015841199,
0.01935124,
-0.0018848397,
0.020968225,
-0.014211067,
0.001442798,
0.014644892,
0.021862168,
-0.0020836764,
-0.0017993893,
-0.022506334,
-0.0048443833,
0.0071581183,
0.0029529703,
-0.015052425,
-0.023413423,
0.0011297535,
0.04277781,
0.035836603,
-0.035310756,
0.030341482,
-0.005741613,
-0.00014008944,
-0.0068886206,
-0.020140013,
0.041331723,
0.006599404,
-0.0112203015,
-0.0053307936,
-0.011272886,
-0.015828053,
0.0006486839,
-0.010135738,
-0.017615939,
-0.029105738,
-0.017339868,
-0.022348579,
0.01628817,
-0.0029595434,
-0.0011363267,
0.013349989,
-0.00081999565,
-0.01736616,
-0.005422817,
-0.001963717,
-0.002016302,
-0.007131826,
0.024517706,
0.010346077,
0.020718448,
-0.018983146,
0.005600291,
0.0023318112,
-0.044670865,
0.00020017178,
0.0129621755,
-0.012140537,
0.018628199,
0.019140901,
0.009491573,
0.002910245,
-0.016971774,
-0.057948552,
0.022742966,
-0.0054063844,
0.010339504,
0.029053153,
0.037782244,
-0.0036217845,
-0.000014609767,
0.008801396,
0.00028141134,
-0.020494962,
-0.003117298,
0.0062115905,
-0.002200349,
0.01136491,
0.020087428,
-0.022506334,
-0.01795774,
0.016721996,
0.0045880317,
-0.005465542,
0.027475607,
-0.020981371,
-0.0060998476,
-0.0017928161,
0.009051175,
-0.008176951,
-0.0032438305,
0.0025355776,
-0.01907517,
-0.010931084,
0.020718448,
0.0012324584,
-0.02554311,
-0.0070923874,
0.02220397,
0.0025273613,
0.006172152,
-0.007808856,
-0.017629085,
0.01563086,
-0.0005320112,
0.014723769,
0.01597266,
-0.00543925,
0.030157436,
-0.019824505,
-0.006842609,
-0.0055542793,
-0.013133077,
-0.0017763834,
0.00084135827,
0.0029184616,
-0.010135738,
-0.025004117,
0.0052354834,
0.0007657675,
-0.0121602565,
0.011903904,
-0.019259216,
0.0034278776,
-0.032944433,
0.0075919437,
0.004269236,
-0.006540246,
-0.0057251803,
-0.021244297,
0.0015446811,
-0.0020787464,
-0.004459856,
-0.0074670548,
-0.009156344,
-0.015709735,
0.0053965244,
0.011312325,
0.0023433142,
0.021296881,
0.007269861,
-0.009366684,
-0.016196147,
0.19572097,
-0.0067275795,
-0.009820228,
-0.0066519887,
-0.024202196,
-0.007927173,
-0.006684854,
0.008643641,
0.013317124,
0.008347851,
-0.0064449357,
0.0039767325,
-0.0127781285,
0.0105104055,
0.015078718,
-0.0038452703,
-0.030709576,
-0.010549844,
-0.0024287647,
-0.025030408,
0.0048476695,
0.011719857,
-0.000978572,
-0.012666386,
0.018233811,
-0.0012045227,
-0.013172516,
0.009741351,
0.025253894,
0.008729092,
-0.02060013,
0.009241794,
-0.0118841855,
0.015775468,
-0.016919188,
-0.007112107,
-0.018877976,
-0.0049594124,
-0.019469555,
0.023124207,
-0.0174056,
-0.0021740566,
-0.039175745,
0.013014761,
-0.011719857,
0.014145336,
0.008025769,
-0.026042668,
0.008834261,
0.0035100414,
-0.040148564,
-0.0029431107,
0.0026522505,
0.01115457,
0.0147500625,
0.005107308,
0.023676347,
0.0032093218,
-0.0068163164,
0.022151386,
0.009090614,
0.019232923,
-0.037282687,
0.045091543,
0.013737803,
0.025635134,
-0.025648281,
-0.0075262124,
0.006438363,
0.0033506434,
0.010556417,
-0.015617712,
-0.009945118,
0.013106784,
-0.00080356287,
-0.010977096,
0.02892169,
0.014605453,
0.0026177417,
0.012357449,
0.003447597,
0.03394355,
-0.042672638,
0.0061885845,
-0.021323174,
-0.042514883,
0.008098073,
0.012101098,
-0.006757159,
-0.0155519815,
0.021520367,
-0.002785356,
-0.0038485567,
-0.00071564753,
0.0031501637,
0.014447699,
-0.00562001,
0.004814804,
-0.029815633,
0.008748812,
-0.03244488,
0.083767734,
0.005843496,
0.0041476334,
-0.025779743,
0.0071712644,
-0.01622244,
0.00543925,
-0.0023055188,
-0.00414106,
0.02112598,
-0.024097027,
-0.0028510871,
-0.0064613684,
-0.0021428342,
0.0104643935,
-0.014013873,
-0.018523028,
0.018733367,
0.014802647,
0.012791275,
-0.022677235,
0.018891122,
0.011706712,
-0.009373257,
-0.001916062,
-0.014079604,
0.016261877,
-0.001916062,
-0.04695831,
-0.008242682,
-0.020113721,
0.003335854,
0.0102803465,
0.014671185,
0.004039177,
0.01212739,
-0.018181227,
-0.012285145,
0.018260103,
-0.0020738167,
-0.019653603,
0.010306639,
-0.00044286338,
-0.011424067,
-0.0021724133,
0.013593194,
0.028553596,
-0.015012987,
0.0025503673,
-0.037335273,
-0.018536175,
-0.008729092,
-0.012271999,
0.018496735,
-0.020508107,
-0.029841926,
-0.032497462,
0.0024221917,
0.003187959,
-0.028895399,
0.01869393,
0.015407373,
-0.03470603,
0.006474515,
-0.008821116,
-0.16469587,
-0.0056134374,
0.0071909837,
-0.022979598,
0.047904838,
0.0012365666,
-0.0052256235,
-0.010812769,
-0.019798212,
0.03084104,
0.027002342,
0.0057810517,
-0.05245343,
-0.020087428,
0.011654126,
-0.004873962,
0.00749992,
0.025990082,
0.03278668,
0.0005685741,
0.020310914,
-0.052611183,
0.006168865,
-0.029763049,
-0.004305388,
0.013856119,
-0.0013064059,
0.029947096,
-0.008919712,
-0.012620374,
0.01273869,
-0.009649328,
0.030735869,
-0.0014230786,
0.019811358,
-0.009517865,
0.016485363,
-0.024281073,
-0.007539359,
0.018089203,
0.02057384,
-0.0013022977,
0.0014756635,
0.014579161,
-0.022572065,
0.03320736,
0.018260103,
-0.024386244,
0.015709735,
0.0065665385,
0.019430118,
-0.034758613,
0.01865449,
0.01816808,
0.00838729,
-0.0020015123,
0.03278668,
0.02478063,
0.023728933,
0.005560852,
-0.0016399913,
-0.023794664,
0.037019763,
-0.005741613,
0.020968225,
-0.03473232,
-0.01333027,
0.015538835,
-0.016261877,
-0.00052872463,
-0.00868308,
-0.018891122,
0.0050021377,
-0.033522867,
0.02081047,
0.02112598,
-0.013869265,
0.019693041,
0.009143198,
-0.0018174653,
-0.011969636,
0.018891122,
-0.000739475,
-0.011213728,
-0.014066459,
-0.016235584,
0.01324482,
0.006954352,
0.009300953,
-0.019758772,
0.02245375,
-0.035784017,
0.0030384208,
-0.01827325,
0.0064712283,
0.0040720426,
0.0134880245,
0.0046110377,
-0.00020181506,
-0.003993165,
0.01712953,
-0.01869393,
-0.027449314,
0.010227761,
0.051322855,
-0.021757,
-0.0066749947,
-0.0026095253,
0.02871135,
-0.024872653,
-0.008466167,
0.014539722,
0.021796437,
0.041726112,
-0.008209816,
0.0077036866,
-0.0019094889,
0.009544157,
-0.010431528,
-0.020665862,
0.066519886,
0.009419269,
0.0017303716,
-0.013474879,
0.0104643935,
-0.015315349,
-0.11221616,
-0.032970726,
0.0073290193,
0.0046143243,
-0.003335854,
0.020731593,
0.009945118,
0.03431164,
-0.027817408,
0.02021889,
-0.015775468,
0.0046866285,
-0.004726067,
-0.029657878,
0.029184615,
0.019140901,
-0.0010648441,
0.002951327,
-0.027659653,
0.019824505,
-0.0072632884,
-0.010319785,
-0.01719526,
0.0057153204,
0.027659653,
-0.0066980007,
-0.014040166,
0.010503832,
0.021283735,
-0.00020705302,
-0.014368822,
-0.03223454,
0.012377169,
-0.0063233334,
-0.014697477,
-0.0018256817,
-0.03449569,
-0.006954352,
0.0066749947,
-0.0021001091,
0.0071778377,
0.020468669,
0.020008551,
0.0026111684,
0.00079698977,
-0.0062641753,
-0.026318738,
-0.003897855,
0.026673686,
-0.0010475896,
-0.0012587508,
-0.010037141,
-0.020389792,
0.00083026616,
-0.006586258,
0.0067144334,
-0.004824664,
0.03512671,
-0.020613277,
-0.006073555,
0.01136491,
-0.0035889188,
-0.0029283212,
-0.001085385,
0.018207518,
0.00739475,
-0.015275911,
-0.002519145,
0.013139649,
-0.030551823,
-0.006228023,
-0.014224214,
-0.0027869993,
-0.024228489,
-0.014579161,
0.007841722,
-0.0042495164,
-0.02213824,
0.0014000727,
0.002785356,
-0.028343257,
-0.01136491,
0.009156344,
0.0039833053,
0.025727158,
0.014539722,
0.009195783,
0.009116906,
0.0071646916,
-0.014671185,
0.0036020651,
0.040280025,
0.016853457,
-0.026423909,
-0.015118157,
0.01510501,
-0.010516978,
-0.016104123,
0.029368661,
0.016511656,
-0.006790024,
-0.025424795,
-0.06352255,
0.014815793,
-0.00365465,
0.0055214134,
0.015065571,
-0.0047687925,
0.026568517,
-0.02408388,
0.00014450574,
0.024097027,
-0.019456409,
0.01628817,
-0.0028675199,
0.011108559,
-0.010208042,
-0.015617712,
0.04440794,
-0.010017422,
0.03291814,
0.029158322,
-0.00019370137,
0.004985705,
-0.0057613323,
0.026581662,
-0.022217117,
-0.018509882,
-0.028316963,
-0.0004728532,
-0.03276039,
0.0040358906,
0.0054918346,
-0.038833942,
-0.022085654,
0.014447699,
-0.0048936815,
-0.013284259,
0.0028132917,
0.02742302,
0.0030170581,
0.041778695,
-0.02794887,
-0.03988564,
0.016025245,
0.010760183,
-0.011378055,
0.0026736131,
-0.04148948,
0.012916164,
0.0059355195,
-0.020981371,
0.023413423,
0.006139286,
-0.013829826,
-0.051059928,
-0.02463602,
0.021967338,
-0.0048410967,
0.00014727878,
-0.013093638,
0.011410922,
0.03052553,
0.010254053,
-0.0031616667,
0.0027524903,
-0.025398502,
0.0030959356,
-0.011180863,
0.005416244,
-0.0049889917,
-0.0042725224,
-0.023084767,
0.0032536902,
0.0032553335,
0.0060801283,
0.015249618,
0.015998954,
-0.010871926,
0.011358337,
-0.004956126,
0.0071055335,
0.005350513,
-0.010720745,
-0.008466167,
0.014092751,
0.040674414,
0.0108785,
-0.010589283,
0.00054803316,
0.0050547225,
-0.002359747,
0.0038354106,
0.005458969,
0.00553456,
0.02683144,
0.022322286,
0.002425478,
-0.007138399,
0.017208405,
0.024662314,
0.035652556,
0.0011075693,
0.010392089,
0.010635294,
-0.025109285,
-0.0017648804,
0.018799098,
-0.05148061,
-0.017668523,
0.0021148985,
-0.022401163,
-0.0008228714,
0.005951952,
-0.033522867,
0.007125253,
-0.012291718,
-0.0014050025,
-0.0060571223,
0.005577285,
-0.0017648804,
0.021060249,
0.021743853,
0.015091863,
-0.014105897,
0.005304501,
-0.004091762,
-0.012436327,
0.006671708,
-0.02178329,
0.021283735,
-0.024662314,
-0.0023811096,
-0.03794,
-0.0015044209,
-0.004653763,
-0.020008551,
-0.01897,
0.0055674254,
0.02095508,
-0.0030548535,
0.090656355,
0.020126868,
-0.009432415,
0.0029579,
-0.020876203,
0.008209816,
0.0368883,
-0.0019817932,
0.0032093218,
-0.016340755,
0.030656992,
-0.026029522,
0.028658766,
-0.03570514,
-0.03633616,
0.022913866,
-0.008512179,
0.0175765,
-0.026108399,
-0.011825028,
0.017076943,
-0.012784702,
0.031997908,
-0.009853094,
-0.021664975,
0.01611727,
0.01709009,
-0.03194532,
0.006648702,
-0.03086733,
0.00335393,
0.0032273978,
-0.05190129,
-0.013303977,
0.020245183,
-0.02492524,
-0.004581459,
-0.019193485,
0.0022693668,
0.0034081582,
0.0011190722,
0.03278668,
0.019574726,
0.0020557407,
0.017024359,
-0.032155663,
-0.04848327,
-0.0068228897,
0.002708122
] |
Now that we have a good understanding of the DNA double strand break (DSB) repair mechanisms and DSB-induced damage signalling, attention is focusing on the changes to the chromatin environment needed for efficient DSB repair. Mutations in chromatin remodelling complexes have been identified in cancers, making it important to evaluate how they impact upon genomic stability. Our current understanding of the DSB repair pathways suggests that each one has distinct requirements for chromatin remodelling. Moreover, restricting the extent of chromatin modifications could be a significant factor regulating the decision of pathway usage. In this review, we evaluate the distinct DSB repair pathways for | [
-0.021644764,
0.01603512,
0.005378115,
-0.046253115,
-0.041966498,
0.018218117,
-0.013375829,
0.009188441,
-0.014129955,
0.020506958,
0.0006718509,
0.0027353636,
-0.0063703875,
0.024912646,
0.0074949623,
0.0098896455,
0.03281113,
-0.010432088,
-0.005682412,
-0.0056394134,
-0.031990856,
0.013025226,
0.013190605,
-0.0051432773,
0.023497004,
0.024595119,
0.016379105,
-0.045829743,
-0.019990977,
0.0072766626,
0.0048158276,
0.019197159,
-0.011450821,
-0.006674684,
-0.008467389,
-0.0013759508,
0.018667948,
-0.015585288,
-0.0074552717,
-0.031355802,
0.0027221334,
0.011086987,
-0.013825659,
0.00828878,
-0.007342814,
0.0078389505,
0.0054608043,
-0.014447482,
-0.01522807,
0.0059503256,
0.018138735,
0.025111102,
-0.039161675,
-0.0016728055,
-0.035086744,
-0.006079321,
0.0058080996,
0.015241301,
0.0045214533,
0.0052458122,
0.0015024655,
-0.0011634391,
-0.01252909,
0.024992028,
-0.03045614,
0.003205039,
0.03500736,
-0.00050647225,
-0.0032761518,
0.017318457,
0.055884767,
0.030085692,
-0.010134406,
0.0027337098,
-0.0061520874,
-0.016418796,
-0.020374656,
-0.009916106,
0.010220403,
0.03278467,
0.014989925,
-0.0027055955,
-0.003539104,
0.026698736,
0.024965568,
0.011550048,
-0.0025402168,
-0.022213666,
0.021578612,
0.010266709,
-0.001661229,
0.02152569,
0.026315058,
0.0036912526,
-0.031011812,
0.017516911,
-0.00091537106,
0.01831073,
-0.016299725,
-0.029318335,
-0.02421144,
-0.005239197,
-0.00693929,
-0.011933726,
-0.034663375,
-0.00983011,
0.026143065,
-0.01563821,
0.001280858,
-0.02057311,
-0.020308504,
0.014381331,
-0.028789124,
-0.011430975,
0.030641364,
-0.010081485,
-0.0033555338,
-0.011219291,
-0.012443093,
0.00068177364,
0.017662445,
0.03939982,
0.023470543,
-0.045353454,
0.0019861981,
-0.015532367,
-0.030985352,
0.017424298,
0.0095390435,
0.0101013305,
0.007528038,
0.014169646,
0.009472892,
0.008037404,
-0.018046124,
0.009155365,
-0.0027287484,
-0.011768348,
-0.02421144,
-0.046385415,
0.014540095,
0.027227947,
-0.013461825,
-0.026156295,
0.0013164144,
0.004779444,
0.013263371,
0.008665844,
0.013236911,
-0.016604021,
0.009651501,
-0.022981023,
0.025296325,
0.0005680758,
0.008765071,
0.026857499,
0.013613974,
0.028947886,
-0.02460835,
-0.026645815,
0.0058510983,
0.0011088641,
-0.0014569863,
-0.0005639414,
0.03855308,
0.025693234,
-0.009486122,
-0.009095828,
-0.008163093,
-0.008745225,
0.010465164,
0.019567607,
-0.032731753,
0.028894965,
-0.027095646,
0.01836365,
-0.007223741,
0.03000631,
-0.033234503,
-0.0005883347,
-0.035615955,
0.0054045757,
0.02692365,
0.008811377,
-0.026791349,
-0.0020920404,
0.013574284,
-0.019924825,
-0.009188441,
-0.004872056,
0.015466215,
-0.0053549623,
-0.0061818557,
-0.02691042,
-0.61642593,
-0.00079464464,
0.00007659101,
-0.010266709,
0.005619568,
0.036886062,
0.004018702,
0.0056625665,
-0.0002608849,
0.019422073,
-0.010908378,
-0.00042750392,
0.017768286,
-0.024872955,
-0.032043777,
-0.040934533,
0.018112274,
-0.009102443,
0.030270915,
0.012707699,
-0.013706586,
-0.004587605,
-0.029424177,
0.0038004024,
0.010193943,
-0.003112427,
0.015254531,
-0.014103495,
0.011292057,
0.024806805,
-0.050672032,
0.0012155334,
-0.013078148,
0.0133956745,
0.043951042,
0.016881857,
-0.011510357,
0.03537781,
0.022001982,
0.04066993,
-0.0129326135,
-0.011047297,
0.020798024,
0.013084763,
-0.013799198,
0.029662322,
0.010782691,
0.009730882,
-0.0032281922,
0.0011601315,
0.016908318,
0.0011212676,
-0.01003518,
0.0077992594,
0.009929337,
0.007084823,
0.021168472,
-0.025613852,
0.0206128,
0.02018943,
0.006377002,
0.01882671,
-0.034292925,
-0.03400186,
-0.015029616,
-0.0025650235,
-0.018231347,
0.009102443,
0.0085798465,
0.0069657504,
0.0048092124,
0.023126557,
0.006932675,
-0.009969028,
0.014235798,
0.03045614,
0.0046372185,
0.014473943,
-0.002631175,
0.026857499,
0.013389059,
-0.019183928,
-0.0070649777,
0.0076272655,
0.029635862,
-0.010478394,
0.004114622,
0.01521484,
-0.0020391194,
-0.018615026,
-0.017159693,
-0.0118014235,
0.0024128752,
-0.029238952,
0.014553325,
0.026222445,
-0.0017050543,
0.011920496,
-0.014831161,
-0.0051168166,
-0.03495444,
-0.0028974346,
-0.012046184,
0.006767296,
0.009274437,
0.010789306,
-0.03259945,
-0.014288719,
0.0374682,
-0.01831073,
0.013719817,
0.0031140808,
-0.03095889,
0.006806987,
-0.009294283,
-0.0264209,
0.030165074,
0.012304175,
-0.008989986,
-0.014989925,
0.011688966,
-0.00963827,
-0.006231469,
-0.035933483,
0.010928224,
0.013289832,
0.019051626,
-0.0065953024,
0.0017067081,
0.0026973265,
0.007223741,
-0.0005486438,
0.029688783,
-0.027889462,
-0.011490512,
-0.010518085,
0.0063075433,
-0.015267761,
-0.0049547455,
-0.04971945,
-0.025322786,
-0.007977868,
0.0073626596,
0.009439816,
-0.023391163,
0.0011973417,
-0.049084395,
0.008454159,
0.007971253,
-0.0026675584,
0.01051147,
0.007567729,
-0.034187082,
0.009744112,
0.0055699544,
0.0065853796,
0.008407853,
-0.04440087,
-0.008143247,
-0.011622814,
-0.0063736946,
-0.000090286434,
-0.0034630299,
-0.009797034,
-0.0008798147,
-0.024595119,
0.014381331,
0.0038797841,
-0.007614035,
-0.035404272,
0.0053814226,
-0.0072171264,
-0.025402168,
0.003089274,
-0.0019547762,
0.019871904,
-0.015439755,
0.014196107,
-0.005136662,
0.014817931,
0.0020655799,
-0.02775716,
-0.018628256,
-0.035139665,
0.020361425,
0.033499107,
0.040087797,
0.00015152823,
0.00076115545,
0.02288841,
0.009770573,
0.00030595058,
-0.0011535164,
0.010683464,
-0.0029305106,
-0.011007606,
-0.0049712835,
0.0036085632,
-0.0026179447,
0.035219047,
0.028947886,
-0.012006493,
0.02508464,
-0.01653787,
0.024767114,
-0.018099044,
0.022491502,
-0.007514808,
0.007395735,
-0.0012816848,
-0.02100971,
-0.009201671,
-0.020692183,
-0.0033009588,
0.0015661363,
0.009062752,
-0.0075081927,
0.016736323,
-0.0106702335,
0.007078208,
-0.024489276,
-0.013521362,
0.019792521,
-0.0037441736,
-0.017212614,
0.011212676,
-0.009274437,
0.0076206503,
0.012079259,
0.009386894,
-0.017397838,
0.033499107,
-0.0071840505,
-0.019620528,
0.008130017,
0.028815584,
-0.0009806957,
-0.007924947,
0.052074444,
-0.014050574,
0.007792644,
0.0024575274,
-0.017860899,
-0.010584236,
0.023470543,
0.0019828905,
0.03532489,
0.036886062,
-0.010862073,
0.010676849,
-0.028471597,
-0.004888594,
-0.024925876,
0.008989986,
0.006479537,
-0.012582011,
0.0027436325,
0.027122106,
0.047311537,
-0.00048001166,
0.011894036,
0.004772829,
0.011510357,
-0.025865227,
0.0056096455,
0.00801756,
-0.004997744,
0.007885256,
-0.0019233542,
0.006760681,
-0.008645998,
0.0035523344,
0.015413295,
-0.025719695,
0.003648254,
-0.007898486,
0.0043196916,
0.03312866,
0.010167482,
-0.001630634,
0.01051147,
-0.026447361,
0.021155242,
0.019488225,
-0.0103064,
-0.010610697,
-0.012489399,
0.006248007,
0.0003396465,
0.025124332,
0.000047623897,
0.005619568,
0.008176323,
-0.00050895294,
-0.025296325,
-0.00072766625,
0.009863186,
-0.03548365,
0.021763837,
-0.014963464,
0.015572058,
0.01071654,
-0.00029416734,
-0.0068268324,
0.03132934,
0.013891811,
0.00285609,
0.014645937,
-0.008679074,
-0.04336891,
-0.010557775,
-0.014116725,
-0.00917521,
-0.020295274,
-0.005427729,
-0.024992028,
-0.0051565077,
-0.008857683,
0.014712089,
0.006767296,
-0.0146327065,
-0.027810082,
-0.0024161828,
0.004997744,
0.034716297,
0.02287518,
-0.016379105,
0.033022817,
0.017159693,
-0.00010811632,
-0.0063075433,
-0.03662146,
0.028868506,
-0.030588442,
-0.0021912677,
0.009294283,
-0.013117838,
0.023960065,
0.0037044827,
0.02868328,
0.017979972,
-0.017741825,
-0.022623805,
-0.011953572,
-0.03363141,
0.00035597765,
0.030641364,
0.049031474,
0.023205938,
0.004752984,
-0.006079321,
0.01477824,
0.0048919017,
-0.032043777,
-0.004779444,
0.033049278,
0.022094594,
0.038156174,
-0.010187328,
-0.02730733,
0.0059966315,
0.004683525,
-0.00139745,
0.0059701707,
0.011788193,
-0.0072105112,
0.026672276,
0.02683104,
0.015108998,
-0.012317405,
0.01746399,
0.0059337877,
-0.04569744,
0.0027618243,
0.017675675,
-0.016604021,
-0.011960187,
-0.020295274,
0.01521484,
-0.013733047,
-0.002002736,
-0.009234746,
-0.005464112,
-0.009142134,
-0.009618425,
-0.014989925,
0.025640313,
-0.0023549926,
0.0113052875,
-0.0034134162,
-0.009896261,
-0.0111796,
-0.014672398,
-0.009413355,
0.004805905,
-0.03262591,
-0.039558582,
0.0043296143,
0.03402832,
0.02863036,
0.028445136,
-0.018231347,
-0.034689836,
0.014725319,
-0.024290822,
-0.023205938,
0.005761794,
-0.020930327,
0.007203896,
-0.0033671102,
-0.015280991,
-0.013177374,
-0.04286616,
0.05146585,
0.018151965,
-0.004316384,
-0.0032248846,
0.004028625,
-0.009836725,
0.042151723,
0.026076913,
0.035959944,
0.015082537,
-0.0077198776,
0.0013007034,
-0.018866401,
-0.016273264,
-0.024727423,
0.005940403,
-0.024793575,
-0.016696634,
-0.0066614537,
0.009631655,
-0.015849894,
0.008606307,
-0.02823345,
-0.0008707188,
-0.0006784661,
0.02953002,
0.009902876,
-0.0033439572,
0.00006666828,
-0.015836664,
0.010855458,
0.008110171,
-0.039558582,
0.044639017,
0.011146524,
-0.0066713765,
-0.0052193515,
-0.0028759355,
-0.0149502335,
-0.011596354,
-0.02008359,
-0.0069591356,
0.050672032,
-0.016630482,
-0.045935586,
-0.0056791045,
0.0048389807,
0.0059800935,
0.011649275,
-0.0039293976,
-0.01831073,
-0.011490512,
-0.0024823342,
0.004822443,
-0.02194906,
0.001171708,
-0.038262013,
-0.013131068,
0.021671224,
0.013799198,
0.005563339,
-0.016670173,
-0.010676849,
-0.029265413,
-0.009247976,
-0.022967793,
-0.046226654,
0.0055368785,
-0.00030512369,
0.043474752,
0.030350298,
0.034716297,
-0.0025980992,
0.000045944267,
0.02153892,
0.0053384244,
-0.029186033,
-0.006119012,
0.010412242,
-0.03040322,
0.00007839984,
0.002700634,
-0.014010883,
0.0017910512,
-0.011100218,
0.036753763,
0.018919323,
-0.008103556,
-0.032864053,
0.017252306,
-0.033499107,
-0.017741825,
0.0035754873,
0.00042006187,
-0.0071509746,
-0.035219047,
0.02418498,
0.010002104,
0.009697807,
-0.0015694438,
-0.0018836634,
0.031673327,
-0.005573262,
0.02463481,
-0.029821087,
0.017411068,
-0.009922721,
-0.008010944,
-0.011186215,
0.00017189048,
0.025256634,
-0.0037937872,
0.026235675,
0.00009323224,
-0.00807048,
-0.008394622,
0.005583185,
-0.011430975,
-0.026076913,
-0.011430975,
-0.019197159,
-0.022015212,
-0.012046184,
0.000884776,
-0.045591597,
0.012026339,
-0.015003155,
-0.0049448228,
0.015188379,
-0.009836725,
0.0010873649,
0.019726371,
0.018046124,
0.009095828,
-0.023073636,
0.018932553,
0.0013279909,
-0.0026741736,
-0.036938984,
-0.010795921,
-0.028471597,
-0.007911717,
0.033843096,
0.034663375,
-0.016365876,
-0.0017397839,
-0.008811377,
0.0066085327,
-0.0054078833,
-0.028127609,
0.0007855488,
0.011550048,
0.009565503,
-0.0003795441,
0.0121189505,
0.005550109,
0.022306278,
-0.0061123967,
0.030112153,
0.0030710823,
-0.023616077,
-0.005804792,
0.006462999,
-0.011371439,
0.024952337,
-0.017199384,
-0.017291997,
-0.0053384244,
0.0022938026,
0.0046537565,
-0.0010162521,
-0.009757343,
0.024872955,
-0.016418796,
-0.016418796,
0.00785218,
0.022306278,
-0.023179477,
-0.030720746,
0.008308626,
0.045935586,
-0.030561982,
-0.0024112214,
0.017543372,
0.012634932,
-0.0014172954,
0.017556602,
0.0059205573,
-0.006119012,
-0.041543126,
-0.0004000097,
0.011808039,
0.01923685,
-0.0061752405,
-0.011576508,
-0.018297499,
-0.0005990843,
-0.02008359,
-0.01321045,
0.035880562,
-0.02950356,
-0.023523465,
0.011960187,
0.020877406,
0.020096818,
0.016789244,
-0.0034795678,
0.00984334,
0.031699788,
-0.0008310279,
0.00016072742,
0.03360495,
0.0078389505,
-0.013574284,
0.011900651,
0.0003760298,
-0.014897313,
0.001925008,
-0.010240248,
-0.022015212,
-0.006512613,
-0.005378115,
0.0077264924,
0.01738461,
-0.033340346,
0.021128781,
0.0047232155,
0.0014933696,
-0.002219382,
-0.0296094,
0.0046636793,
-0.023417624,
0.008467389,
0.0064596916,
-0.0133229075,
-0.019620528,
-0.01659079,
-0.013772737,
0.002561716,
-0.015466215,
0.0017447452,
-0.015611749,
-0.0042436174,
-0.0027304022,
0.0012047838,
0.0059635555,
-0.02325886,
-0.019117776,
0.003406801,
-0.0010981145,
-0.0045346837,
0.001754668,
0.0073295836,
0.026698736,
0.010650388,
-0.032916974,
0.0071840505,
-0.023907144,
-0.028974347,
-0.0255477,
-0.008130017,
-0.029953388,
0.024727423,
0.027571935,
0.00053334626,
-0.011715427,
-0.013111223,
-0.044003963,
-0.027677778,
0.010703309,
-0.0051498925,
0.0031636944,
0.034822136,
-0.009459661,
0.012608471,
0.008077095,
0.009697807,
0.0058510983,
0.008163093,
0.0038996297,
0.0033869557,
0.030614903,
0.008870913,
-0.027836543,
-0.0016107885,
0.026116604,
-0.0025484858,
-0.015175149,
0.010577621,
0.007461887,
0.03551011,
-0.0069789807,
0.012277714,
0.014381331,
0.030376758,
0.0075015775,
0.0017000929,
-0.0037144055,
-0.013375829,
0.008573231,
-0.009413355,
0.0071311295,
-0.013733047,
0.014579786,
0.0025369092,
-0.0065093054,
-0.02099648,
0.007858795,
-0.034795675,
0.011258981,
0.015016385,
0.020652492,
0.011358209,
-0.0063902326,
-0.006214931,
0.005665874,
-0.015069307,
-0.017794747,
-0.012145411,
-0.014381331,
-0.015280991,
-0.017331688,
0.002887512,
-0.01123252,
-0.019594068,
0.016088039,
-0.022650266,
-0.015135458,
-0.017781517,
0.023523465,
-0.0015694438,
0.0036614842,
-0.0013858734,
0.0022226896,
-0.034398768,
-0.0019117777,
0.016842166,
0.010233633,
-0.016511409,
0.02508464,
-0.012277714,
-0.026248906,
0.034240004,
0.0002805236,
-0.0068665235,
-0.026487052,
0.005563339,
0.19898364,
-0.0013618935,
-0.015082537,
0.011245751,
0.014976694,
-0.020321734,
0.02545509,
0.012846617,
-0.031382263,
0.0053715,
0.013018611,
0.010227018,
-0.0045743748,
0.0010840574,
0.039082292,
0.0028461674,
-0.023060406,
-0.004673602,
-0.014659167,
0.019594068,
0.018112274,
-0.016908318,
-0.0037110979,
-0.011245751,
0.011675736,
-0.0032100005,
-0.028577438,
-0.013448595,
0.00801756,
0.02552124,
-0.02284872,
0.015757281,
0.006287698,
-0.010200558,
0.014963464,
-0.009472892,
-0.0068003717,
-0.031699788,
-0.018495953,
-0.008553386,
0.00019711073,
0.009221516,
-0.02284872,
-0.005626183,
-0.009208285,
0.005993324,
-0.012026339,
-0.011589739,
0.0064663067,
0.00008997635,
-0.032229,
0.012859847,
0.024568658,
0.02462158,
-0.006155395,
-0.022213666,
0.01966022,
-0.015294221,
0.002507141,
0.013627204,
-0.023893913,
-0.010504855,
-0.02865682,
0.020758335,
-0.0028511286,
0.00983011,
-0.012198333,
0.019355923,
0.03262591,
-0.033313885,
-0.0073295836,
-0.013785968,
-0.02505818,
-0.004997744,
-0.004359382,
-0.005053973,
0.048105355,
0.0029619324,
0.044109806,
0.02775716,
-0.000115868446,
-0.00853354,
-0.023113327,
0.0073163533,
0.01477824,
-0.012582011,
0.037785724,
-0.015598519,
-0.012582011,
-0.0029685476,
0.019488225,
0.016881857,
-0.016286494,
0.017027391,
-0.0048158276,
-0.00218796,
-0.0083350865,
0.004974591,
-0.01278708,
-0.0027304022,
-0.037441738,
0.08546771,
0.00041820138,
0.015254531,
-0.007574344,
0.00005400648,
0.017979972,
0.018548874,
-0.008116786,
0.0001826401,
0.020017438,
-0.009863186,
0.019395614,
-0.0023632615,
0.00032414225,
0.016379105,
0.009109058,
-0.03712421,
0.039585043,
-0.010802536,
0.009109058,
-0.017411068,
-0.00014677359,
0.009056137,
-0.0062017012,
-0.017543372,
-0.020559879,
0.0043825353,
-0.014712089,
-0.02239889,
-0.01123252,
-0.016008658,
0.003269537,
0.00335388,
0.010617312,
-0.027810082,
0.03712421,
-0.018257808,
-0.008645998,
-0.0000774179,
-0.0004994437,
-0.007309738,
0.0061851633,
0.01138467,
-0.009849955,
-0.013746277,
0.0078124893,
0.014050574,
-0.016696634,
-0.0103064,
-0.025005259,
0.011821269,
-0.0012370326,
0.005675797,
0.0035754873,
-0.00875184,
-0.006036322,
-0.03979673,
-0.003097543,
0.029424177,
-0.04164897,
0.019726371,
0.0071906657,
-0.0042270795,
-0.01882671,
0.008612922,
-0.16479656,
0.041040376,
0.026936881,
-0.027492555,
0.025838766,
0.016736323,
0.019488225,
0.006674684,
0.0032629217,
0.009922721,
0.0022243434,
0.012112335,
-0.065093055,
-0.020890636,
0.0064828447,
0.00007638428,
0.0073163533,
0.027439633,
0.022173975,
0.014672398,
-0.0022144208,
-0.02865682,
0.011894036,
-0.015849894,
-0.00936705,
0.005923865,
-0.0067110676,
-0.008255704,
-0.0016819013,
-0.010200558,
-0.010736384,
-0.0069591356,
0.02246504,
-0.017172923,
0.019805752,
0.009056137,
-0.009294283,
-0.0024161828,
0.0001416055,
0.014116725,
0.022147514,
0.029291874,
0.004657064,
0.00086493057,
0.012628317,
0.0255477,
0.01273416,
-0.027175028,
0.009982258,
0.00081159594,
0.010901763,
0.007428811,
0.005619568,
0.011688966,
0.038606003,
0.0065159206,
-0.01881348,
0.017662445,
-0.010676849,
-0.011788193,
-0.015863124,
-0.007574344,
0.039981954,
-0.0034497995,
-0.019038396,
-0.017133232,
-0.0066713765,
0.002889166,
-0.041384365,
0.019792521,
-0.0074221957,
-0.0068731387,
0.011589739,
0.005540186,
0.0070385174,
0.002879243,
0.00030739765,
0.0061587025,
-0.03085305,
-0.024343744,
-0.010537931,
0.012277714,
-0.0367273,
-0.021631533,
0.008612922,
0.0049481303,
-0.007303123,
-0.0020110048,
-0.014659167,
0.0116955815,
0.022068134,
-0.02153892,
0.034557533,
-0.023457315,
0.020361425,
0.0059635555,
0.007223741,
-0.0126150865,
-0.011973417,
0.000594123,
0.00064911135,
-0.017186154,
-0.023893913,
0.023602847,
0.02681781,
0.015902815,
0.003988934,
0.0028660127,
0.040960994,
-0.008645998,
-0.006605225,
-0.0069525205,
0.0046008355,
0.0072435867,
0.0038202477,
0.03180563,
-0.0056956424,
0.021234624,
0.0030413142,
-0.008487235,
0.08165739,
-0.0055071106,
-0.0121917175,
-0.002755209,
0.03127642,
-0.029186033,
-0.128916,
-0.006453077,
-0.011490512,
0.023325011,
0.01049824,
-0.0007632227,
0.0048489035,
0.026553202,
-0.012469553,
0.021724146,
-0.03818263,
-0.007792644,
0.0077264924,
-0.021684455,
-0.019369153,
-0.008454159,
0.010802536,
-0.0134287495,
0.009413355,
0.02503172,
0.0053351168,
-0.0046901396,
0.0009947529,
-0.0114111295,
0.0206128,
0.00392609,
-0.021829987,
0.005510418,
-0.0037706343,
0.0165511,
-0.0037044827,
-0.011960187,
-0.002530294,
-0.0031818862,
-0.03453107,
-0.008639383,
-0.0072369715,
-0.041066837,
0.041913576,
-0.007117899,
-0.014116725,
-0.002303725,
0.016405566,
0.009241361,
0.005692335,
-0.0015793665,
-0.01701416,
0.018707639,
0.012939229,
0.0014321795,
-0.017265536,
0.00524912,
-0.021075862,
-0.013772737,
0.0022408813,
-0.017662445,
-0.0059800935,
0.0020936942,
-0.00201762,
0.017199384,
-0.022610575,
0.01142436,
-0.010399012,
0.004719908,
0.019779291,
-0.02466127,
-0.018998705,
-0.003889707,
0.029371256,
-0.014685628,
0.007309738,
0.009697807,
-0.022001982,
-0.003578795,
-0.027360251,
0.002080464,
-0.036383312,
-0.0109877605,
-0.0024856417,
0.00040062988,
0.0007049267,
-0.003889707,
0.019805752,
-0.022054903,
0.025600621,
-0.009664731,
-0.00021189146,
-0.015069307,
0.00785218,
-0.0046306034,
-0.016934779,
0.04066993,
-0.02233274,
-0.026341518,
-0.011391285,
0.009082598,
0.0018390111,
-0.018628256,
0.009512583,
0.027942384,
-0.023668999,
-0.004822443,
-0.041278522,
0.010703309,
0.008983371,
0.00302643,
-0.0037276358,
0.0068202172,
-0.0035589496,
-0.016868627,
-0.008996601,
0.022121053,
-0.013422135,
0.011391285,
-0.0060892436,
-0.004683525,
-0.038103253,
-0.027889462,
0.012866463,
-0.023325011,
-0.009062752,
0.035219047,
-0.010696694,
-0.022226896,
0.026487052,
0.014434253,
-0.001141113,
-0.0005672489,
-0.0062281615,
0.011543433,
-0.02556093,
-0.020546649,
0.0073560444,
-0.028445136,
-0.040087797,
0.0013213757,
-0.003833478,
-0.011854345,
-0.01746399,
0.030350298,
0.035563033,
0.036012866,
-0.00538473,
-0.043659974,
-0.008116786,
0.00015628287,
-0.013051687,
0.001132844,
-0.04702047,
0.014831161,
-0.00024021255,
-0.02102294,
0.03979673,
0.008454159,
0.0010848843,
-0.01969991,
-0.003011546,
0.0011245752,
-0.0027519015,
0.00807048,
-0.0044123037,
-0.03275821,
0.01790059,
0.026619354,
0.011020836,
0.012469553,
0.011880806,
-0.00447184,
-0.023086866,
-0.019514685,
0.013680126,
-0.028789124,
0.0030793513,
0.031355802,
0.006787142,
-0.01434164,
-0.02153892,
-0.0018191657,
-0.010908378,
-0.035430733,
-0.005067203,
0.013838889,
0.01252909,
-0.0018158581,
0.004098084,
0.028709741,
0.03937336,
-0.0041873883,
-0.011550048,
0.020665722,
0.003833478,
-0.0022723032,
0.014129955,
0.024489276,
0.036171626,
0.024026217,
0.002444297,
0.039585043,
-0.025296325,
0.008632768,
0.004627296,
0.014037344,
-0.01049824,
-0.0046901396,
0.009757343,
-0.00091619795,
-0.0062546222,
0.027783621,
0.0025336016,
-0.015373603,
0.008844453,
0.018681178,
0.011206061,
0.014685628,
0.016696634,
0.0040220097,
-0.008930449,
0.012562166,
-0.009995488,
-0.0065622265,
-0.007746338,
0.011199445,
0.010557775,
0.004306461,
-0.018998705,
0.010365937,
0.025666773,
0.011682351,
0.019594068,
-0.013653665,
0.009896261,
-0.015082537,
0.039188135,
-0.0043726126,
-0.011662506,
-0.011034067,
-0.00717082,
-0.010485009,
-0.005053973,
0.031646866,
-0.01790059,
0.089913085,
0.029794626,
-0.01967345,
0.010107946,
-0.03818263,
0.01967345,
0.024264362,
0.0046702945,
-0.0022491503,
-0.031038273,
0.012350481,
-0.021234624,
0.0025352554,
-0.023192707,
-0.008394622,
0.036991905,
-0.017239075,
0.018151965,
0.009552273,
-0.021314006,
0.00670776,
-0.020255582,
0.0059503256,
0.0120528,
-0.013111223,
-0.0065556113,
0.00582133,
-0.0047629066,
-0.001800974,
0.0040881615,
-0.0015628287,
-0.0073692747,
-0.02102294,
-0.00058957504,
-0.0012742429,
0.0013668549,
0.0021069245,
-0.019713141,
0.0054839575,
0.018972244,
0.0041311597,
-0.012271099,
0.01787413,
-0.03392248,
-0.009896261,
0.009816879,
0.0065787644,
-0.020665722,
0.002662597
] |
A comprehensive mapping of interactions among Epstein-Barr virus (EBV) proteins and interactions of EBV proteins with human proteins should provide specific hypotheses and a broad perspective on EBV strategies for replication and persistence. Interactions of EBV proteins with each other and with human proteins were assessed by using a stringent high-throughput yeast two-hybrid system. Overall, 43 interactions between EBV proteins and 173 interactions between EBV and human proteins were identified. EBV-EBV and EBV-human protein interaction, or "interactome" maps provided a framework for hypotheses of protein function. For example, LF2, an EBV | [
-0.03476298,
-0.021994524,
-0.004860869,
-0.04261439,
-0.01724931,
-0.0057927286,
0.006532929,
0.011274837,
-0.021981306,
-0.0022949514,
-0.026382854,
-0.018478572,
0.0069988584,
0.004520509,
-0.021108927,
-0.004199976,
0.020302637,
-0.014751135,
0.0014721395,
0.0074813105,
-0.03830537,
0.0048344336,
-0.0047386037,
-0.03693071,
-0.01373336,
0.02252324,
0.017592976,
-0.041028246,
-0.014381035,
0.005333408,
0.017407926,
0.010660207,
-0.009391292,
0.0070847743,
0.013118729,
-0.012477662,
0.0017579758,
0.012708975,
0.025391515,
0.006271876,
0.009430945,
0.017711936,
-0.026633995,
0.016178664,
0.010237235,
0.007216953,
-0.0020091152,
-0.015319503,
-0.008307427,
0.017394708,
-0.0026485294,
0.010561072,
-0.008267773,
0.03582041,
-0.009292157,
-0.010792385,
0.0027691424,
-0.005386279,
0.0020338986,
-0.025087504,
-0.014235638,
-0.001213565,
-0.022840466,
0.0044577243,
-0.016918864,
0.0037637865,
0.011658155,
-0.004613034,
0.015663167,
0.020738827,
0.043618947,
0.01187625,
-0.012708975,
0.023659974,
0.02213992,
-0.015716039,
-0.02437374,
-0.027413847,
-0.009748174,
0.011268228,
0.0022123398,
-0.017143568,
-0.000879814,
0.00408432,
0.00890884,
-0.013561527,
0.009966268,
-0.0012102606,
0.024254778,
0.00013930388,
0.00020621931,
0.008419779,
0.01193573,
0.013971281,
-0.025907012,
0.017778026,
0.0043123276,
0.043222412,
0.008036461,
-0.012656104,
-0.015068363,
-0.0039091827,
-0.024968542,
-0.013944846,
-0.0016836253,
-0.0020190286,
0.028127613,
-0.018015947,
0.01305264,
-0.014645392,
-0.030506827,
0.03267456,
-0.012894025,
-0.039309923,
0.013125338,
0.01101048,
0.0056935945,
-0.018795801,
-0.018809019,
0.014169549,
0.012173652,
0.024796711,
-0.009014582,
-0.03531813,
0.035476744,
0.02015724,
-0.0056803767,
-0.010224017,
0.02363354,
-0.001596057,
0.0109840445,
0.018716494,
-0.00017782157,
-0.015887871,
-0.0233824,
0.00952347,
-0.00797698,
-0.023329528,
0.007031903,
-0.0031557647,
0.022047395,
0.021730166,
-0.011182312,
-0.017037826,
-0.015174107,
0.031167721,
0.0060438677,
0.016456239,
0.0014556171,
0.015795346,
-0.015742475,
-0.008915449,
0.02195487,
-0.02783682,
-0.01602005,
0.015359157,
-0.018531444,
0.037803087,
-0.038939822,
-0.029264348,
-0.02437374,
0.0033936864,
0.015187324,
0.010382631,
0.009926615,
0.03830537,
-0.0042198026,
-0.011169095,
0.01812169,
-0.028894247,
-0.027493155,
0.026686866,
-0.05234274,
-0.006625454,
-0.009668867,
0.0002001267,
0.010349587,
-0.000034671073,
-0.021716949,
-0.039362796,
0.008855968,
0.0035291694,
0.027731076,
0.018531444,
-0.02548404,
0.006618845,
0.025867358,
-0.029608013,
0.008492477,
-0.004242934,
0.0045733806,
0.012860981,
-0.0051186173,
0.0038926606,
-0.63403445,
-0.028524147,
0.002162773,
-0.013145165,
0.004689037,
0.0022321667,
0.005449064,
0.007243389,
0.0030847187,
0.024043292,
-0.015002274,
0.019681398,
0.015174107,
-0.023950767,
-0.01886189,
-0.0252329,
-0.007904282,
-0.028312663,
0.027149491,
0.0028633196,
-0.025946666,
0.021360066,
0.0050360058,
0.026012754,
-0.0015886219,
-0.013343433,
0.02728167,
-0.026990876,
-0.008267773,
0.020580212,
-0.019179119,
0.027519591,
0.004107451,
0.0046064253,
0.039865073,
-0.0041603222,
0.0067510237,
0.015002274,
0.023673192,
0.03434001,
0.016403368,
-0.019694615,
0.008234728,
0.020077934,
-0.027228797,
0.023025516,
-0.0084131695,
0.0025180029,
-0.0046163388,
-0.02015724,
-0.0038563116,
0.0151212355,
-0.034921594,
-0.020064715,
0.016297625,
0.013865538,
0.008637873,
-0.021333631,
0.010607335,
0.0036382168,
0.00970852,
-0.005868731,
0.011896077,
0.0050624413,
-0.0093648555,
0.006698152,
-0.02165086,
0.009206242,
-0.0023676497,
0.004137191,
0.027757512,
0.02913217,
0.011981993,
0.004897218,
0.005670463,
0.027995434,
-0.0027460111,
0.030771185,
-0.014896532,
-0.015980396,
-0.00010259334,
-0.0074747014,
-0.027889691,
-0.004418071,
-0.0020685955,
0.012827936,
-0.021003185,
0.033467628,
0.0067807636,
-0.00884275,
-0.0041603222,
0.005554807,
-0.005498631,
-0.010098447,
-0.01948313,
0.002625398,
-0.0067642415,
0.0028649718,
0.011638328,
-0.012583406,
0.007527573,
-0.027440283,
0.023289874,
-0.004953394,
-0.008452823,
0.005016179,
-0.0031772438,
0.008836142,
0.046051033,
0.004636165,
0.006384228,
-0.00810255,
-0.004546945,
-0.0011045177,
-0.0021445982,
-0.02654147,
0.025338642,
0.001781107,
0.0007224388,
-0.018994069,
0.016601635,
-0.009371465,
0.0010227321,
-0.009226068,
-0.0025031327,
0.014922967,
0.0003670022,
-0.0152534135,
-0.014751135,
-0.017923422,
-0.000089736895,
0.004946785,
0.0077588856,
-0.011426843,
0.028444842,
0.01726253,
0.025061067,
0.013601181,
-0.018994069,
-0.026488597,
-0.018584315,
-0.009853917,
-0.0028087958,
-0.0038794428,
-0.027572462,
-0.005042615,
0.000368861,
-0.020249765,
0.02418869,
0.013720142,
0.034181394,
0.00293767,
-0.0015374026,
0.021901999,
0.019549219,
-0.008406561,
-0.010706469,
-0.023765717,
-0.009741565,
-0.019271644,
0.006271876,
0.016231535,
-0.010739514,
-0.007038512,
0.030982671,
-0.016310843,
0.007904282,
0.0005022788,
-0.007243389,
-0.040790323,
0.02876207,
-0.0135747455,
-0.02387146,
0.02622424,
-0.020381944,
0.033256143,
0.007031903,
-0.006420577,
0.0012639582,
-0.015081582,
-0.006714674,
-0.0042627607,
-0.0023808675,
-0.010713078,
0.05207838,
0.0043718084,
0.03698358,
-0.007144255,
0.00933842,
0.015702821,
0.0055944603,
0.0052474914,
0.0009359899,
0.018253868,
0.016852776,
-0.012266177,
-0.0044676377,
0.01576891,
-0.0042032804,
0.025589783,
0.0010846909,
-0.009054236,
-0.015755692,
-0.015689604,
0.0073557408,
-0.014989057,
-0.01669416,
-0.03989151,
0.0044312887,
-0.017288964,
0.0040777107,
-0.008889013,
-0.029475834,
0.00417354,
-0.015702821,
0.0031673303,
-0.014275292,
0.01924521,
-0.013217863,
-0.0012540447,
-0.006093435,
0.0035655184,
0.01948313,
-0.0034994292,
0.011896077,
0.0004667558,
-0.008915449,
0.021412939,
0.008545348,
0.0037373507,
0.0017414534,
0.015108017,
0.040367354,
-0.0024717404,
0.0040050126,
0.0030351519,
0.020077934,
-0.017407926,
0.038543288,
0.01613901,
-0.024690967,
0.020395162,
0.0065428424,
0.0063677053,
0.0064106635,
0.0019149379,
-0.012854371,
0.025021415,
-0.0022685158,
0.03222515,
-0.0137994485,
0.021161798,
-0.019337734,
-0.0102768885,
-0.0009996009,
-0.018227434,
-0.012728802,
0.016984954,
0.05400819,
0.013065858,
0.0014655306,
-0.012847763,
0.021875564,
0.0032615077,
0.0152534135,
-0.0050855726,
-0.015174107,
-0.020791698,
-0.015306286,
0.0011144311,
-0.012689148,
-0.00046427743,
0.004028144,
-0.005151662,
0.010488374,
0.027149491,
0.00028129265,
0.018227434,
0.006295007,
0.01465861,
-0.051443923,
-0.016813122,
0.016852776,
0.013997717,
0.005832382,
-0.014222421,
-0.008974929,
-0.027678205,
0.0026733128,
0.0005146705,
0.0063412697,
0.009007974,
0.014566085,
0.015795346,
0.0028583629,
0.004527118,
0.014975838,
-0.03378486,
-0.014063806,
0.0030549786,
-0.00052127946,
0.00006799971,
-0.007858019,
-0.0128015,
0.03772378,
0.0028484494,
-0.00259731,
-0.020976748,
-0.0012970028,
-0.012034864,
0.012259568,
0.00890884,
-0.00030669573,
-0.019271644,
-0.001049994,
0.018148126,
-0.01564995,
0.0115259765,
-0.009107107,
0.010851866,
-0.025523692,
-0.05041293,
-0.005373061,
-0.0077588856,
0.03957428,
0.021307195,
-0.00055184576,
0.02913217,
0.026316766,
-0.0043519814,
-0.01978714,
-0.038199622,
0.017976293,
0.00649658,
0.007580444,
-0.0054589775,
-0.0010045576,
0.0043123276,
0.018399265,
0.020196894,
0.008373517,
-0.040552404,
0.019007286,
-0.004305719,
0.0011929121,
0.0094573805,
0.021915216,
0.032251585,
0.019998627,
0.0061892644,
0.0013878756,
0.030771185,
-0.0079108905,
-0.022047395,
0.0020537255,
0.023104824,
0.007395394,
0.01978714,
-0.019324515,
-0.031564258,
0.020434815,
0.025497258,
0.02139972,
0.017963076,
0.01892798,
0.013720142,
-0.009126934,
0.0036481302,
-0.017553322,
0.014671828,
0.0043123276,
-0.0010846909,
-0.00041677573,
-0.02270829,
0.0071112104,
0.003178896,
-0.0024849582,
-0.0327803,
-0.018756147,
-0.008770052,
0.0027972301,
-0.01107657,
-0.0176855,
-0.008036461,
-0.012279395,
-0.013191427,
0.014724699,
0.0075540086,
0.00040479706,
-0.014328163,
-0.019443477,
-0.02269507,
-0.008446215,
-0.019721052,
0.011658155,
-0.029634448,
-0.030876927,
0.001348222,
0.010296715,
0.018412484,
0.0067807636,
-0.020672737,
-0.0028897552,
0.0059282114,
-0.022959428,
-0.012444618,
0.0058621224,
-0.021901999,
-0.00686668,
0.0061000437,
-0.0050987904,
-0.022840466,
-0.01781768,
-0.007395394,
-0.0049566985,
-0.007580444,
0.0066023227,
-0.011274837,
0.0020372032,
0.01812169,
-0.0011590413,
0.032912478,
-0.010098447,
-0.021849127,
0.0011392146,
-0.03656061,
0.0076663606,
-0.020196894,
-0.003866225,
-0.0072830427,
-0.025246117,
-0.010138101,
-0.023699628,
-0.012953506,
0.0021181626,
-0.0039455323,
0.00859822,
0.010904737,
0.025457604,
0.033494066,
-0.0068534617,
0.0084131695,
0.0074747014,
-0.02566909,
-0.01354831,
-0.00093846826,
0.018584315,
-0.019284861,
-0.022047395,
0.0026072233,
0.017725155,
-0.0312999,
0.0031227202,
-0.013264125,
-0.03283317,
0.009107107,
0.008300818,
0.007487919,
-0.04705559,
-0.017355055,
0.0040611885,
0.014222421,
-0.00054069323,
-0.011155876,
0.00258244,
-0.012530534,
0.015729256,
0.004229716,
0.015385592,
-0.03637556,
0.0053433212,
0.04552232,
-0.014499996,
0.004213194,
0.016998172,
0.00946399,
-0.026316766,
0.0067939814,
-0.031987227,
-0.025510475,
-0.0058951667,
0.008585002,
0.05863444,
0.023554232,
0.028074741,
0.0002858363,
0.014526431,
0.01596718,
0.02077848,
0.004434593,
-0.015702821,
-0.0053631477,
-0.01181016,
0.013502047,
0.008941884,
-0.0058786445,
0.013984499,
-0.006258658,
0.002959149,
0.0130724665,
-0.0075540086,
-0.0039686635,
-0.014909749,
-0.021161798,
0.0069856406,
0.009358247,
-0.015412028,
0.018108472,
-0.03727437,
0.003611781,
0.0013027856,
-0.00495009,
0.011182312,
0.005924907,
0.014156331,
-0.016601635,
0.02629033,
-0.0073491316,
-0.0077721034,
0.0034432532,
0.0102768885,
-0.020011844,
-0.018901544,
0.040288046,
0.0068204175,
0.022787595,
-0.0038992695,
-0.014566085,
-0.009794436,
-0.006846853,
-0.0065725823,
-0.008095941,
-0.0024519137,
-0.013131947,
-0.013680488,
-0.02529899,
-0.027916126,
-0.02195487,
-0.009946442,
-0.009159979,
0.008128986,
0.014856878,
-0.0022949514,
-0.024228342,
0.044887863,
0.00046303825,
0.03359981,
-0.026369637,
0.051866893,
0.028444842,
0.005924907,
-0.030030984,
-0.017275747,
-0.013105511,
0.016482675,
-0.0005514327,
0.020738827,
0.0007145907,
-0.020077934,
0.010567681,
-0.0042627607,
-0.0030830665,
-0.039468538,
0.027004095,
-0.007990198,
0.008280992,
-0.006618845,
-0.016482675,
-0.009497034,
0.016852776,
-0.024611661,
0.014724699,
0.0005468891,
-0.011671373,
-0.009186415,
0.012219914,
0.009126934,
0.024836365,
-0.007223562,
-0.02387146,
-0.022999082,
-0.022906557,
0.015068363,
-0.016495893,
0.00040706887,
0.026766172,
0.019932536,
0.022377841,
0.001007036,
-0.005848904,
0.00835369,
-0.003624999,
0.008776661,
0.03997082,
-0.007064948,
-0.0026055712,
-0.008195075,
0.0037770043,
0.020976748,
-0.011155876,
0.0057993373,
-0.006625454,
-0.021624424,
-0.0029624535,
0.03642843,
0.033917036,
0.017143568,
-0.010184363,
-0.008697354,
0.012913852,
-0.022787595,
-0.009609386,
0.013971281,
-0.059163153,
-0.004348677,
0.00395875,
0.03690427,
0.027678205,
0.018980851,
0.01255697,
-0.00983409,
0.021479027,
-0.023950767,
0.004983134,
0.012761846,
0.005145053,
-0.032727428,
-0.011473105,
-0.032330893,
0.011796943,
0.0004667558,
-0.0065957136,
-0.014922967,
-0.004510596,
-0.0015944047,
0.042693697,
0.022999082,
-0.03526526,
0.024624879,
-0.029475834,
0.010990653,
-0.011136049,
0.0080232425,
0.00208677,
0.001553925,
0.0043817214,
0.0037670908,
-0.032251585,
0.00095912116,
-0.0028220138,
-0.011248401,
-0.013521873,
-0.017460797,
-0.014235638,
-0.02307839,
0.0020735522,
0.019522784,
-0.00041760187,
0.0050062654,
-0.018386047,
-0.011036916,
-0.0015547511,
-0.0057861195,
0.014698263,
-0.0076729693,
0.010342978,
-0.0012011733,
0.012953506,
-0.0076465337,
0.0009376421,
-0.0031689827,
-0.035767537,
-0.01335665,
0.019654961,
-0.002142946,
0.022814032,
-0.0034300354,
-0.0031888094,
-0.021730166,
-0.007131037,
-0.04467638,
0.0020124195,
-0.0037439596,
0.007117819,
-0.009794436,
0.0061165662,
-0.01960209,
0.004973221,
-0.008677527,
0.023170915,
-0.0033044657,
-0.020395162,
0.022285316,
-0.007527573,
0.02213992,
0.022457149,
-0.030453956,
-0.015425246,
0.031458512,
0.014751135,
-0.0048146066,
0.02437374,
-0.020249765,
0.014050588,
-0.0071839085,
0.009926615,
-0.010164537,
0.027056966,
0.0027014008,
-0.027334541,
-0.013958063,
0.018029165,
-0.007223562,
-0.029105734,
-0.007653143,
-0.005521762,
0.008010025,
0.011281446,
-0.007223562,
-0.030665442,
0.008142203,
-0.0001156563,
0.01830674,
0.0077654943,
0.0021313804,
0.019840011,
0.00006345607,
0.013006377,
0.003859616,
0.0011829988,
-0.0057729017,
-0.006959205,
0.012226523,
0.003129329,
-0.012173652,
-0.0061264792,
0.0045865984,
-0.017474014,
-0.004768344,
-0.0064602303,
-0.03259525,
-0.018756147,
0.02003828,
0.02307839,
-0.008122377,
-0.0038860517,
-0.02077848,
-0.002668356,
-0.03656061,
0.009021192,
-0.018980851,
0.005221056,
-0.0079175,
-0.0029145388,
-0.011175703,
-0.020606648,
0.001071473,
0.024479482,
-0.003605172,
-0.0049401764,
0.18695346,
-0.025351861,
0.0067939814,
0.0035985631,
-0.02578805,
0.0041669314,
0.0019149379,
0.002660095,
0.026700083,
-0.019906102,
0.015914306,
0.01633728,
-0.016456239,
0.0042958055,
0.030771185,
0.0037803089,
-0.038437545,
-0.012160433,
-0.023541015,
-0.0066651073,
0.007249998,
-0.004533727,
0.020276202,
-0.017738372,
0.026819045,
-0.016271189,
-0.038886953,
0.0076861875,
-0.003519256,
0.00017668566,
-0.014420688,
-0.009166588,
-0.014724699,
0.016376931,
-0.00971513,
0.019403823,
0.011420233,
-0.021227889,
0.0015811869,
-0.0029608014,
0.008644482,
0.016244754,
-0.030771185,
-0.026885133,
-0.0053036674,
-0.0023676497,
-0.0027195753,
-0.03481585,
0.011684591,
0.011453278,
-0.028629892,
0.0070054675,
-0.008307427,
0.029951677,
0.0040182304,
0.0037439596,
0.021426156,
-0.0014349642,
-0.01354831,
0.033282578,
-0.007844802,
0.009556515,
-0.018319959,
0.010012531,
-0.015319503,
0.02615815,
0.0010103404,
0.016839558,
0.020395162,
-0.018663622,
0.017711936,
-0.024598442,
-0.02183591,
0.0112087475,
-0.018703276,
-0.008314036,
0.04020874,
0.011724245,
0.02294621,
-0.0006286746,
0.02233819,
0.02399042,
-0.05004283,
0.00516488,
-0.010924564,
-0.023778936,
0.029793063,
0.008043069,
-0.019654961,
-0.011711027,
0.028524147,
-0.0031392425,
-0.008029852,
-0.003469689,
0.032198712,
0.014870096,
-0.02467775,
-0.005277232,
-0.012781673,
0.0011152572,
-0.017976293,
0.08327254,
0.0035489963,
0.0052970587,
-0.030136727,
-0.0011301272,
-0.0006798938,
-0.00084057346,
0.0092326775,
-0.0009442511,
0.01323769,
-0.016469456,
0.0052177515,
-0.0050492235,
0.003952141,
0.013508656,
0.019879665,
-0.0036514346,
0.01855788,
0.009886961,
-0.001454791,
-0.012649495,
0.01761941,
0.036322687,
-0.025510475,
-0.004028144,
-0.01144006,
0.009311984,
-0.011981993,
-0.028603455,
0.013343433,
0.011096396,
-0.004533727,
0.006754328,
0.02102962,
-0.016271189,
0.012933679,
-0.00485426,
-0.01991932,
0.010224017,
-0.008076115,
-0.02325022,
0.0085255215,
0.03605833,
-0.024056511,
-0.0014696611,
0.01342274,
0.030295342,
0.007838192,
-0.011367362,
0.0005344973,
-0.020196894,
0.01126162,
-0.012537143,
0.0053301034,
-0.026078844,
-0.0037836132,
-0.019139465,
-0.0029707146,
-0.01465861,
-0.038622595,
0.01069986,
0.016165446,
-0.029370092,
-0.020566994,
0.002774099,
-0.16569912,
-0.009404509,
-0.010376022,
0.0050987904,
0.037935268,
0.020302637,
0.005941429,
-0.011975383,
0.004477551,
0.011050133,
0.01867684,
0.002347823,
-0.046474006,
-0.04142478,
0.00018153909,
-0.002015724,
-0.0021842518,
0.01998541,
0.043830432,
-0.006622149,
0.019443477,
-0.027942562,
0.013528483,
-0.020487687,
0.0138919735,
0.017156785,
-0.012213306,
0.002070248,
-0.004335459,
-0.010832039,
-0.013151773,
0.0066684117,
0.051073823,
-0.011030307,
0.0074680927,
-0.02839197,
0.0029541925,
-0.00037485032,
-0.0049005225,
0.010224017,
0.051734716,
0.02215314,
-0.0027658378,
0.01775159,
-0.010250453,
0.024572007,
0.029026426,
-0.0012119128,
0.015623514,
-0.021241106,
0.02163764,
-0.018888326,
0.013508656,
0.012761846,
0.017421143,
-0.016376931,
0.013720142,
0.015240196,
0.0068931156,
0.0067378054,
-0.017711936,
-0.025497258,
0.044332713,
-0.020236548,
0.01923199,
-0.046606183,
-0.0117308535,
0.023342745,
-0.012504098,
0.00067080656,
-0.00871718,
0.01354831,
0.013997717,
0.00417354,
0.0035093427,
0.027995434,
-0.03211941,
0.0048146066,
0.0107791675,
-0.024215125,
-0.014077024,
0.032991786,
-0.016046485,
-0.01193573,
-0.026885133,
-0.012675931,
-0.013098902,
0.011182312,
-0.004596512,
-0.014579303,
0.009556515,
-0.013270735,
-0.0058918623,
-0.025603,
0.016469456,
0.0076399245,
0.02622424,
0.0032235063,
0.0008831185,
0.0070583387,
0.020461252,
-0.012609841,
-0.014896532,
0.0070186853,
0.04293162,
-0.032013662,
-0.0058786445,
-0.0037869178,
0.05858157,
-0.0057431613,
-0.018148126,
-0.011089787,
0.02436052,
0.03193436,
-0.0061628288,
0.01576891,
-0.02022333,
0.016416585,
-0.008452823,
-0.014790788,
0.06603644,
0.0146189565,
-0.03285961,
0.018042384,
-0.032515943,
-0.0028534061,
-0.11917225,
-0.016165446,
0.0011739115,
-0.007864628,
-0.007448266,
0.028418405,
0.014764353,
0.031432077,
-0.011889468,
0.0259731,
-0.037591603,
-0.012728802,
-0.010283497,
-0.024069728,
0.013958063,
0.011221966,
0.0017711936,
0.01780446,
-0.01701139,
0.031696435,
0.022047395,
-0.008049678,
-0.012451227,
-0.010415676,
0.020051498,
0.009259113,
-0.018346393,
0.025603,
0.010151318,
0.013693706,
0.0023379095,
-0.019694615,
0.016654508,
-0.0016010136,
-0.011724245,
-0.0019314602,
-0.017659064,
-0.033441193,
0.022734724,
-0.039653588,
0.0023180826,
0.018888326,
0.014632174,
-0.006470144,
-0.002888103,
-0.018822236,
-0.02709662,
0.002128076,
0.0015109669,
0.00454364,
-0.020210112,
-0.016429804,
-0.047478564,
-0.016561983,
0.016429804,
-0.012841154,
-0.010957608,
0.026329983,
-0.0048344336,
0.0050128745,
-0.016984954,
-0.0131716,
-0.018452136,
-0.003135938,
0.019496348,
-0.019377386,
-0.005260709,
0.00015995679,
0.031960793,
-0.023593886,
-0.020566994,
-0.013383086,
-0.016257972,
0.0034597756,
-0.0053796703,
0.0064337947,
-0.010693251,
-0.012067908,
0.021492245,
-0.012200087,
-0.017857334,
-0.020210112,
0.019377386,
0.0072632157,
0.04486143,
0.0055316756,
0.00044692899,
0.015795346,
-0.007904282,
0.0003370555,
0.016231535,
0.05387601,
0.02139972,
-0.028788505,
-0.01106996,
0.012338875,
-0.029396527,
-0.021968089,
0.010693251,
0.03642843,
-0.020633085,
0.010494983,
-0.056202352,
0.015597078,
-0.0074614836,
-0.006747719,
0.025338642,
-0.0019017201,
0.0056803767,
0.007904282,
-0.0033821207,
0.03211941,
-0.0142092025,
0.015874654,
-0.011109614,
0.0075143552,
-0.0051186173,
0.0020487688,
0.04100181,
-0.013323606,
0.014499996,
0.0324102,
-0.0056010694,
-0.006159524,
0.011103005,
0.017910205,
-0.008948493,
-0.010243843,
-0.021730166,
0.01960209,
-0.014328163,
-0.012821327,
0.0046064253,
-0.025021415,
-0.010224017,
0.015848218,
-0.006222309,
-0.012880808,
0.00103595,
0.013997717,
0.011519368,
0.045628063,
-0.021901999,
-0.03301822,
-0.0053400164,
-0.0007038512,
0.011638328,
0.0046427744,
-0.05078303,
0.019324515,
0.009331811,
-0.03283317,
0.012656104,
0.012609841,
-0.011373971,
-0.035476744,
-0.0012755238,
-0.006625454,
-0.0065725823,
-0.01181677,
-0.008466042,
0.0021578162,
0.013627617,
0.011704418,
0.00089798856,
-0.000004492008,
-0.02089744,
-0.0013003072,
-0.022496803,
-0.01726253,
-0.005974474,
-0.018954415,
-0.005796033,
0.023051953,
-0.006618845,
0.016125793,
0.007692796,
-0.0069063334,
-0.004626252,
0.025008196,
-0.015610296,
0.007990198,
0.013316997,
-0.038701903,
0.0023362574,
0.003284639,
0.042270724,
0.014367817,
-0.0057497704,
0.024611661,
-0.00061710895,
0.0015877958,
0.0021016402,
0.014156331,
0.005313581,
0.01849179,
0.0103694135,
0.00522436,
-0.0124314,
0.028180484,
0.0067444146,
0.01391841,
-0.023237003,
0.004335459,
0.006017432,
-0.029925242,
-0.01929808,
0.0056605497,
-0.02232497,
-0.03767091,
-0.0130724665,
0.00088146626,
0.010812212,
0.011929121,
-0.014671828,
-0.0055812425,
0.015478117,
-0.005918298,
0.0126627125,
0.0010128188,
-0.008439605,
0.032383762,
0.015597078,
0.021862345,
-0.012451227,
-0.009880353,
0.037803087,
0.018161343,
-0.0103694135,
-0.016099356,
0.020421598,
-0.014090242,
-0.0027625333,
-0.03341476,
-0.00047956058,
-0.02363354,
-0.004285892,
0.0029475833,
-0.0055878516,
0.013376477,
-0.004798084,
0.07962441,
0.014526431,
-0.014737917,
0.012656104,
-0.048218764,
0.005901776,
0.03550318,
0.012973333,
-0.010415676,
-0.03830537,
0.024664532,
-0.019390605,
0.011182312,
-0.040473096,
-0.015597078,
0.022628982,
-0.013680488,
0.018438919,
-0.02344849,
-0.0009401205,
0.015517771,
-0.024043292,
0.00797698,
-0.000858335,
-0.029634448,
-0.0015836651,
0.008082723,
0.0053895838,
-0.0022387756,
-0.038622595,
0.013706923,
-0.00953008,
-0.03867547,
0.00014921727,
0.026316766,
0.0024981762,
-0.012021646,
-0.027070183,
0.010812212,
0.008247946,
0.004044666,
0.0030830665,
-0.006807199,
-0.0036646526,
0.010752732,
-0.0058918623,
-0.03301822,
-0.015901089,
0.00008395408
] |
CONTEXT Medicare's reimbursement policy was changed in 1998 to provide coverage for screening colonoscopies for patients with increased colon cancer risk, and expanded further in 2001 to cover screening colonoscopies for all individuals. OBJECTIVE To determine whether the Medicare reimbursement policy changes were associated with an increase in either colonoscopy use or early stage colon cancer diagnosis. DESIGN, SETTING, AND PARTICIPANTS Patients in the Surveillance, Epidemiology, and End Results Medicare linked database who were 67 years of age and older and had a primary diagnosis of colon cancer during 1992-2002, as well as a group of Medicare beneficiaries | [
0.009693317,
-0.0071092984,
0.024502732,
-0.05931557,
-0.011803383,
0.013413525,
-0.010699656,
-0.00038630434,
-0.029787635,
0.012225396,
0.0051258365,
0.023593782,
0.02351587,
0.0025418175,
-0.030151216,
0.019230815,
0.031631507,
-0.0041844225,
0.0038435657,
0.009940033,
-0.01942559,
0.014231581,
-0.013880986,
0.012348753,
0.0058919527,
-0.0033468888,
0.028670924,
-0.03443627,
0.013738151,
0.0061873617,
0.023113335,
-0.009576452,
-0.014725013,
-0.023360051,
-0.02351587,
0.012115023,
0.022360204,
0.014932772,
0.015101578,
0.0007969556,
-0.00956996,
0.003707223,
-0.015439188,
-0.014608148,
0.008420785,
0.00817407,
0.021879759,
-0.0044376305,
-0.034566123,
0.013868001,
0.0142965065,
-0.0010728872,
-0.030852407,
-0.0036747605,
-0.014569192,
-0.014478297,
-0.022931544,
0.027034812,
-0.014867848,
-0.021736924,
0.01697142,
-0.010517866,
-0.014932772,
0.000098300654,
-0.0022918559,
-0.007894892,
0.005437477,
-0.010939879,
-0.0040708035,
0.015556053,
0.06331496,
0.0333715,
0.0021668752,
0.008979141,
0.0076611615,
-0.013121363,
-0.0051615452,
-0.009940033,
0.0064210924,
0.010797044,
0.026554365,
-0.0024087213,
-0.017763507,
0.030566737,
0.010855476,
0.009686825,
0.010758089,
0.027086752,
0.005005725,
0.012251366,
0.03251449,
0.021788863,
0.017464852,
0.023269156,
0.017685596,
0.021801848,
0.0061873617,
0.020814987,
0.014569192,
0.0025499333,
-0.018815294,
0.019049024,
-0.018062163,
-0.0065639275,
-0.019399619,
0.00080872327,
-0.0045512496,
-0.019282755,
0.029216295,
-0.018075148,
-0.015309338,
0.036254175,
0.0030628415,
-0.006089974,
0.018101117,
-0.015114563,
-0.0062717646,
0.017867386,
0.012102039,
-0.02693093,
-0.0096478695,
-0.005206993,
0.043785486,
-0.015711874,
0.012829199,
-0.009608914,
-0.036747605,
-0.0018422497,
0.019854095,
-0.0071157906,
0.0024768924,
0.00075069646,
0.042435043,
0.038513567,
-0.009044066,
0.018036192,
-0.020529317,
-0.004535018,
-0.044928167,
-0.040695053,
0.0052654254,
0.018828278,
-0.002316203,
0.0023908666,
-0.03344941,
0.0071482533,
0.025762279,
0.012173456,
0.014426357,
-0.007875415,
-0.0039928937,
-0.021217521,
-0.010615254,
0.01166704,
0.013932926,
0.011160624,
0.011037267,
0.01156316,
-0.0030190172,
-0.015971575,
-0.009699809,
-0.01981514,
0.012894125,
0.00007370013,
-0.0018876973,
0.01885425,
0.014140686,
0.010517866,
-0.011998158,
0.0056614685,
-0.0010712642,
0.031060167,
0.00027593167,
0.006862583,
-0.018140072,
0.0040675574,
-0.00843377,
0.012887632,
-0.02664526,
-0.035630893,
-0.027658092,
0.011095699,
0.021659013,
0.005453708,
-0.019672304,
-0.013725166,
0.029865544,
-0.00990757,
-0.016049484,
-0.024061242,
0.0024281987,
0.022191398,
-0.016023515,
-0.0067132553,
-0.6361621,
-0.012595469,
-0.007232656,
-0.01582874,
0.022879604,
0.022840649,
0.00580755,
0.016010528,
-0.03433239,
0.00501871,
0.02075006,
0.0021814832,
0.024100196,
0.008764888,
-0.017477836,
-0.0020840957,
0.010504881,
0.010459433,
0.008946679,
0.0014981467,
-0.029112414,
0.015620979,
-0.01119958,
0.032384638,
0.006099713,
0.031735387,
0.0065606814,
-0.028411223,
0.01632217,
0.018867234,
-0.01153719,
0.012050098,
0.007700117,
0.007440416,
0.032384638,
0.0037591632,
-0.0020289093,
-0.011167116,
-0.0069210157,
0.016075455,
-0.0053400896,
-0.010056898,
0.01989305,
0.013971881,
-0.025866158,
0.021594089,
0.013387555,
-0.005155053,
0.0035643878,
0.003067711,
0.012186441,
0.020646181,
0.0070768357,
0.009414139,
0.027528241,
0.014413372,
0.034384333,
-0.043759517,
0.006112698,
-0.002267509,
-0.027268542,
0.015530083,
-0.024398852,
-0.021490207,
-0.010712641,
0.036851484,
-0.019308724,
-0.007868922,
0.022801695,
0.005606282,
0.040876843,
0.010842492,
-0.014608148,
-0.02007484,
0.03157957,
0.0028615736,
0.0017286307,
0.008394815,
-0.02010081,
-0.0019509993,
-0.00024955586,
0.011290475,
-0.021620058,
0.015257398,
0.006265272,
-0.008505188,
-0.019776184,
0.0030092783,
-0.010719134,
-0.0005234586,
0.01575083,
-0.010926894,
0.00043540393,
-0.03991595,
-0.01275129,
-0.00023677372,
-0.021217521,
-0.0033192956,
0.028125552,
-0.020996777,
-0.026398545,
0.01145928,
-0.01329666,
0.01564695,
0.027839882,
0.0061743767,
-0.015776798,
-0.0030255096,
0.037916258,
-0.044019215,
0.035734773,
-0.000028354008,
-0.022840649,
-0.008797351,
-0.015711874,
-0.027891822,
0.009388169,
0.028437193,
-0.019178875,
0.0053433357,
0.0076351915,
-0.009797198,
-0.01730903,
-0.012705842,
0.038305808,
0.0136472555,
0.007706609,
-0.00210195,
0.01143331,
-0.017412912,
-0.008524666,
-0.017711567,
0.0048206886,
0.014309492,
-0.0037039767,
-0.018360818,
0.024892282,
-0.01689351,
-0.029631814,
-0.03230673,
-0.025203923,
-0.012907109,
0.022749754,
-0.007842951,
0.005538111,
-0.008446755,
-0.03254046,
-0.010829506,
-0.003525433,
0.0046031894,
-0.015517099,
-0.01151122,
0.00825198,
-0.00025077318,
-0.006797658,
0.0073170587,
0.004918076,
-0.00060299184,
-0.014608148,
-0.01754276,
0.010180255,
0.00045285255,
-0.0015728105,
0.0017140226,
0.011219057,
-0.0026570596,
0.0067067626,
0.007284596,
-0.021931699,
-0.019451559,
-0.000113618924,
0.014867848,
0.0034247988,
-0.0020402712,
0.0017562238,
0.024307957,
-0.007693624,
0.0076351915,
0.004148714,
0.006645084,
0.018919174,
-0.018685443,
0.0009406024,
0.0013358339,
0.02385348,
0.01697142,
0.020113796,
-0.018971113,
0.0003759569,
0.02700884,
-0.007927354,
0.020879911,
-0.0014965235,
0.0043110265,
-0.018581564,
0.0027739247,
0.0032884562,
-0.008128623,
0.018997084,
0.012712334,
0.0151405325,
-0.002280494,
0.014517252,
-0.004622667,
-0.010693164,
-0.0044603543,
0.015659934,
-0.0064275847,
0.007589744,
0.00801825,
-0.006479525,
-0.02247707,
0.005603036,
-0.0012903863,
0.006609375,
0.024931237,
-0.0053757983,
-0.002611612,
-0.003398829,
0.011757935,
-0.006073743,
0.013465465,
0.026034964,
-0.004148714,
-0.018230967,
0.00804422,
-0.0025450638,
0.01332263,
-0.010004957,
-0.0041584526,
-0.0007539427,
0.030878376,
0.008466233,
0.044902198,
0.019386634,
0.038331777,
-0.010615254,
-0.005969863,
0.010569806,
0.013738151,
0.004304534,
0.011796891,
0.021853788,
0.0041844225,
-0.01140734,
-0.015361278,
0.034592092,
0.0036130818,
-0.019620365,
0.00004917569,
0.00843377,
0.010258165,
0.002061372,
0.0061548995,
-0.0154781435,
-0.00804422,
0.0064665396,
0.042512953,
0.02687899,
0.02664526,
0.036773577,
-0.003720208,
-0.020542301,
-0.0034247988,
-0.0011848831,
0.012738304,
0.018607533,
-0.005271918,
0.003580619,
-0.022957515,
0.0042980416,
-0.0056874384,
0.0059114303,
-0.043292057,
-0.018958129,
0.0096219,
0.016490975,
0.0026830297,
0.012640917,
0.015543069,
-0.014179641,
-0.020996777,
0.029553905,
0.03212494,
-0.01665978,
-0.012816214,
0.008641531,
-0.005583558,
-0.0015265513,
0.01652993,
0.0032105462,
0.0029865545,
-0.024139151,
0.0077650417,
0.00022480315,
-0.004892106,
0.019178875,
-0.0111411465,
0.005320612,
0.013984866,
-0.007700117,
-0.0067197476,
-0.016101424,
-0.016231274,
0.030358976,
-0.0031991843,
-0.014737997,
-0.03357926,
-0.010706149,
-0.006330197,
0.0041811764,
-0.027450332,
-0.015296353,
0.011894278,
0.0029118906,
0.007297581,
-0.01140734,
-0.01689351,
0.0035514028,
-0.00504468,
-0.012647409,
-0.029450025,
-0.0024801388,
-0.016724706,
0.05251142,
0.018230967,
0.007803997,
0.029969426,
0.029839575,
-0.020217676,
0.009758242,
-0.04583712,
0.015906649,
0.009115484,
-0.013491435,
0.02325617,
0.038305808,
0.0039441995,
0.013335615,
0.024983177,
0.016439036,
-0.019568425,
0.004788226,
-0.008472726,
-0.012199426,
0.009011604,
0.049836505,
0.055108424,
0.005713409,
-0.036098354,
0.028593013,
0.027632121,
0.013945911,
-0.017166195,
-0.037786406,
0.008349367,
-0.023424976,
0.021243492,
-0.017153211,
0.0020808494,
0.021412298,
-0.000017765637,
-0.0001691096,
0.0006735979,
0.014893818,
-0.009303766,
0.012225396,
0.0003826523,
0.023931392,
-0.02258095,
-0.0022009609,
0.017283062,
0.019295739,
-0.02268483,
-0.00018868857,
3.8517575e-7,
-0.0014413372,
-0.014010836,
0.029164353,
-0.0034734928,
-0.021048717,
0.009160931,
-0.027554212,
0.008057205,
-0.0051031127,
-0.024100196,
0.010848984,
0.0053303507,
-0.008446755,
-0.012556514,
-0.020620212,
-0.007803997,
-0.0073560136,
0.01582874,
0.0048823673,
0.0006817135,
0.0031472442,
0.013751136,
0.012537036,
0.008641531,
0.0272166,
-0.001197868,
0.0078169815,
0.014387402,
0.021035733,
-0.003580619,
0.005349828,
-0.008271458,
0.010401001,
0.004648637,
-0.014945758,
-0.01937365,
-0.022645874,
0.054069623,
-0.0032689788,
-0.01634814,
-0.009368692,
-0.00959593,
0.0038435657,
0.0093102595,
0.0039409534,
0.004512294,
-0.018192012,
-0.020970806,
-0.010264658,
-0.018490668,
-0.030592706,
0.0011296967,
0.002330811,
-0.005424492,
-0.0051518064,
0.008232502,
-0.0017984252,
-0.032955978,
0.014205611,
-0.031813297,
0.023528855,
-0.017244106,
0.018568577,
0.00677818,
-0.030904347,
0.017763507,
0.01564695,
-0.010686671,
0.0023097105,
0.009375184,
0.010121822,
0.0058757216,
-0.030229125,
-0.01913992,
-0.012920095,
0.0015508983,
-0.021425283,
-0.010251673,
-0.009823168,
0.039266698,
-0.0056354986,
-0.05248545,
-0.017958282,
-0.0033533813,
-0.0017172688,
0.00851168,
-0.02664526,
-0.015633963,
-0.0056841923,
0.006148407,
-0.004918076,
-0.030307036,
0.0454216,
-0.02328214,
0.003272225,
0.0053822906,
0.0014827269,
0.017919326,
0.023139305,
0.0015362902,
0.0010672063,
0.025749294,
-0.011498235,
-0.011920248,
0.016932465,
-0.008784366,
0.043240115,
0.042642806,
0.014114716,
-0.000080344806,
0.024814373,
0.0063107195,
0.003208923,
0.0039539384,
-0.011348907,
0.0192438,
0.015348293,
0.029475994,
-0.0019282755,
-0.0043207654,
0.0053757983,
0.0036844993,
0.031917177,
-0.025931085,
-0.0035384179,
0.011134654,
-0.028463162,
-0.03339747,
-0.02698287,
-0.0025580488,
-0.0056225136,
0.0037494244,
-0.03820193,
-0.012822707,
0.009303766,
0.0103230905,
0.006609375,
0.008816828,
0.021996623,
-0.006128929,
0.031449717,
-0.0027641861,
-0.0013926433,
-0.0029346144,
-0.011602115,
-0.026904961,
-0.017581716,
0.010764581,
0.002736593,
0.011180102,
0.0047687483,
-0.02716466,
-0.0012514313,
0.019126933,
-0.037474766,
-0.0101542855,
-0.0034799853,
-0.032384638,
0.010017943,
-0.016075455,
0.011868308,
-0.0038370732,
-0.022840649,
0.024230046,
-0.009264812,
0.01582874,
0.007323551,
-0.02641153,
0.0007803185,
-0.00031204626,
0.0078104893,
-0.03355329,
-0.0019087979,
0.0130564375,
-0.015231428,
-0.017503807,
0.0065801586,
-0.0162962,
-0.0033306575,
0.02578825,
0.03451418,
0.0026083658,
0.008673993,
-0.009362199,
0.024411837,
-0.018075148,
-0.035189405,
0.00009784415,
0.009427125,
0.018594548,
-0.0038857672,
-0.018023208,
-0.008894739,
0.019126933,
0.010030928,
-0.011063237,
0.0014348447,
-0.01598456,
-0.01702336,
0.014725013,
-0.05136874,
-0.0077845193,
-0.014828892,
-0.025177954,
-0.014958743,
-0.00856362,
-0.001986708,
0.0019899542,
-0.012335769,
0.0068236277,
-0.004142221,
0.013868001,
-0.008693471,
-0.00019244205,
-0.0060445266,
-0.013361585,
-0.022269309,
0.028567044,
0.010628238,
-0.008083175,
0.000055592114,
0.011186594,
0.008466233,
-0.011939726,
-0.01606247,
-0.013932926,
-0.02036051,
0.005820535,
0.034644034,
0.031449717,
-0.030514795,
-0.002137659,
-0.0017253845,
0.021983638,
-0.020789016,
0.0019720998,
0.006417846,
-0.0072781034,
-0.009842644,
0.008570113,
0.01720515,
0.04150012,
0.010582791,
0.0121280085,
-0.01321875,
0.020763047,
-0.017516792,
0.016906496,
0.005921169,
-0.0025823957,
0.0034280452,
0.0048336736,
-0.017503807,
-0.021736924,
0.005567327,
-0.008096159,
-0.04085087,
-0.026619291,
-0.008057205,
0.0048077037,
0.021074686,
-0.0016028384,
-0.017867386,
0.030800467,
0.0012920095,
-0.016711721,
-0.02700884,
0.02354184,
-0.015906649,
0.019204844,
0.006109452,
-0.0019656073,
0.018698428,
-0.016140379,
0.016049484,
-0.016776646,
-0.022035578,
-0.010030928,
-0.0087454105,
0.0107451035,
-0.020827971,
0.007713102,
-0.0061841155,
0.009173917,
-0.0042883027,
0.015789784,
0.008316905,
-0.009368692,
-0.0034734928,
-0.012829199,
0.023373036,
0.010835999,
-0.0015557676,
-0.015348293,
-0.01754276,
-0.007563774,
0.0019591148,
0.0060834815,
-0.015335308,
0.04092878,
0.013634271,
0.009946525,
-0.014776953,
-0.030514795,
-0.0462007,
-0.0064860173,
-0.0016166349,
0.031034198,
0.0043142727,
0.017815446,
0.005346582,
0.015685903,
0.00013471958,
-0.0056322524,
-0.03243658,
-0.0261778,
0.028593013,
-0.013082407,
0.010959357,
0.020113796,
-0.03905894,
-0.00030332195,
0.0096219,
0.023269156,
0.0026148583,
0.029294204,
-0.0395264,
-0.0013812814,
-0.014945758,
-0.015062623,
-0.0168156,
-0.01337457,
-0.004661622,
-0.036280144,
0.012608454,
0.0030011628,
0.007466386,
-0.0019152904,
-0.014023821,
-0.0146341175,
0.009693317,
-0.005106359,
-0.0077520567,
-0.018880218,
0.013283676,
-0.043162204,
-0.009466079,
0.03396881,
0.01112167,
0.015218443,
0.005336843,
-0.0029589613,
-0.0131408395,
0.0057848264,
0.007537804,
0.0021457744,
0.008102653,
-0.0048726285,
0.007349521,
-0.008167577,
-0.01736097,
0.014179641,
-0.0021717446,
-0.028229432,
-0.013906956,
-0.009771227,
0.023580795,
-0.0323327,
-0.021009762,
0.009297274,
0.004392183,
-0.028151523,
-0.013186287,
-0.02674914,
-0.005476432,
-0.024256017,
0.012076069,
0.002736593,
0.004444123,
0.012082561,
0.01119958,
-0.011115177,
-0.008245488,
0.021282448,
0.1973723,
0.00086431537,
-0.0024379375,
0.031605538,
0.009134961,
0.0065736664,
0.027580181,
0.026502425,
-0.024853328,
0.02667123,
0.0010874954,
-0.006356167,
-0.01691948,
0.0061191907,
0.030021366,
-0.0049505387,
-0.028307343,
-0.014049791,
0.00951802,
0.010900924,
0.004509048,
0.003986401,
-0.017412912,
-0.0136472555,
-0.0007356825,
0.0051128515,
0.01177092,
0.016854556,
0.03344941,
0.011894278,
-0.00954399,
-0.023645721,
0.011050251,
0.021269463,
-0.0010972342,
-0.0014332215,
-0.015802769,
-0.012400694,
-0.005956878,
-0.009505034,
-0.006661315,
0.0074923565,
-0.02075006,
-0.021503193,
0.025710339,
0.017607687,
0.0016174465,
0.0028859207,
0.0018941897,
0.0027528242,
-0.048330244,
-0.0027463317,
0.015841724,
0.005219978,
-0.0037104695,
-0.009641377,
0.013283676,
-0.009342722,
0.019620365,
0.012504574,
0.011322937,
0.008953171,
-0.010465926,
0.018763354,
-0.014465312,
0.019100964,
0.007284596,
0.004512294,
0.023879452,
-0.02206155,
-0.009245334,
-0.01588068,
-0.0032852099,
-0.0077455644,
0.0059374003,
-0.011751443,
0.03918879,
0.014997697,
0.010355554,
0.000465026,
-0.0025109781,
-0.007044373,
-0.012640917,
-0.012563007,
-0.02578825,
-0.024658551,
0.015530083,
0.008297428,
-0.009823168,
0.015556053,
-0.022451099,
0.0006058323,
-0.030073306,
-0.008888246,
-0.008570113,
0.012400694,
0.009466079,
0.022269309,
-0.029398084,
-0.011277489,
-0.013634271,
0.08544143,
-0.005310873,
-0.011680026,
0.0057978113,
-0.0016190696,
-0.011907263,
0.03165748,
0.008953171,
-0.002926499,
0.04072102,
-0.021334387,
0.0162962,
-0.0107451035,
0.012270844,
0.032670308,
0.016244259,
-0.042538926,
-0.002176614,
-0.005434231,
-0.023191245,
-0.036695667,
-0.014984713,
0.04100669,
-0.01942559,
-0.01153719,
0.000598934,
-0.032202847,
-0.0044603543,
-0.034384333,
-0.027917793,
-0.011913756,
0.0013902087,
-0.012147486,
0.00820004,
0.006992433,
0.015036653,
-0.010193241,
-0.024152137,
0.016465005,
0.007927354,
-0.009712795,
0.0016637057,
0.009173917,
0.0019753461,
0.0056354986,
-0.011842338,
0.0013293414,
-0.015530083,
-0.0037429319,
-0.022074534,
-0.015387248,
0.009459587,
0.0040578186,
0.031112107,
-0.056614686,
-0.024100196,
-0.050174117,
0.0018065409,
0.004505802,
-0.027736003,
-0.017153211,
0.049187254,
-0.010608761,
0.0026343358,
0.0149717275,
-0.16194916,
0.010660701,
0.0133096455,
-0.002139282,
0.0040772962,
-0.014504267,
-0.029475994,
-0.00025665702,
-0.012673379,
-0.014075762,
0.013699195,
-0.00037676847,
-0.03300792,
-0.0085766055,
0.015387248,
0.009219364,
-0.029683756,
0.027294511,
0.007667654,
0.005031695,
0.035397165,
-0.024139151,
0.0073170587,
-0.030592706,
0.0053855367,
-0.0012449388,
-0.015270383,
0.049914416,
-0.029995395,
-0.01016727,
-0.02602198,
0.022697814,
0.011212564,
-0.004804457,
-0.035942536,
0.01665978,
-0.01634814,
-0.011595623,
-0.027787942,
0.013043452,
0.022074534,
0.022723785,
0.015530083,
0.012582484,
-0.029995395,
0.022035578,
0.048486065,
-0.016309185,
0.03965625,
0.0024785157,
0.00075718894,
-0.022606919,
0.019594396,
0.0003936084,
0.0015419711,
0.008141607,
0.007219671,
-0.009297274,
0.0056225136,
0.01316681,
-0.014114716,
-0.034384333,
-0.0034605078,
-0.0052362094,
-0.017828433,
-0.017516792,
0.0076741464,
-0.020957822,
-0.008005264,
0.005307627,
-0.014452327,
0.015776798,
0.00011828541,
-0.021009762,
0.06347077,
0.0002795837,
-0.009264812,
0.00801825,
-0.009037574,
-0.007842951,
-0.000846461,
0.0008570113,
-0.027528241,
-0.025762279,
0.011764428,
0.022152444,
0.012588977,
0.0065541887,
0.018321862,
-0.024983177,
0.017581716,
-0.03313777,
-0.0016336777,
-0.005680946,
0.0047395322,
0.014426357,
-0.00040821655,
-0.021412298,
-0.010686671,
-0.039838042,
0.0107451035,
-0.011699502,
-0.027658092,
0.03350135,
0.008927201,
0.01164107,
-0.006356167,
0.008797351,
0.019932006,
-0.005710162,
-0.01908798,
0.0272166,
0.035267312,
0.003999386,
-0.014205611,
0.031631507,
-0.005398522,
-0.014010836,
-0.020503346,
-0.0081545925,
0.018750368,
-0.010498389,
0.022087518,
-0.029268235,
0.010251673,
0.008602575,
-0.10907417,
-0.01634814,
0.010017943,
-0.003668268,
0.021866772,
0.0033663663,
-0.030722557,
-0.012420171,
0.0050089713,
0.0148029225,
-0.0047817333,
-0.006021803,
-0.004265579,
-0.02075006,
0.035864625,
-0.014725013,
-0.0053433357,
-0.0229705,
0.0057491176,
0.02361975,
-0.0017270076,
-0.008732426,
0.0074858638,
-0.04591503,
-0.0041811764,
-0.036591787,
-0.018997084,
0.017049331,
0.014049791,
0.025697354,
-0.02356781,
-0.004749271,
0.0039409534,
-0.016127395,
-0.005489417,
-0.017568732,
-0.005057665,
-0.021074686,
0.017425897,
-0.028618984,
0.011680026,
0.029917486,
-0.015543069,
-0.017763507,
0.007855937,
-0.020555286,
-0.010868462,
-0.0039799083,
0.0035221865,
-0.016283214,
0.00078640523,
-0.0015281745,
-0.024723478,
-0.0055348645,
-0.021386327,
-0.009401154,
0.00087243103,
0.00035668226,
-0.0014827269,
-0.019646335,
-0.02651541,
-0.008037727,
-0.025372729,
0.005564081,
-0.0009308636,
-0.013212257,
-0.0013942665,
-0.011556667,
-0.012855169,
-0.012115023,
-0.018984098,
0.01725709,
-0.01942559,
0.022360204,
-0.03394284,
-0.020633196,
-0.003794872,
-0.011855323,
0.018192012,
-0.022554979,
0.013803076,
-0.00491483,
0.026268695,
-0.036877457,
0.02046439,
0.024204077,
0.010134808,
0.0035059552,
0.017620672,
-0.026164815,
0.01999693,
0.028541073,
0.0064405696,
-0.027839882,
0.018802308,
0.007037881,
0.0067002703,
0.0017740784,
-0.015491129,
0.017438881,
-0.023139305,
0.003186199,
-0.06009467,
0.006304227,
-0.0047168084,
-0.009258319,
0.019776184,
0.007920862,
0.031735387,
-0.012257858,
0.0072910883,
0.018269923,
-0.041811764,
0.05316067,
-0.010102346,
0.013075915,
-0.005450462,
-0.009862122,
0.010530851,
0.015815753,
0.037760437,
0.013751136,
-0.011160624,
0.031138077,
0.0083818305,
0.005583558,
0.008868769,
0.028541073,
-0.0009511527,
0.018243952,
-0.0022886097,
-0.014945758,
0.007154746,
0.017997237,
-0.014387402,
0.0031748372,
-0.01637411,
-0.018204998,
0.0141277015,
-0.017893357,
0.03407269,
0.014010836,
0.0053920294,
-0.021568118,
0.008109145,
-0.016231274,
-0.0328521,
-0.0091674235,
0.0038143494,
0.036384024,
-0.03147569,
-0.003590358,
0.010511373,
-0.0045512496,
-0.0060315416,
-0.031164046,
-0.018230967,
-0.009920555,
0.018075148,
0.0020727338,
-0.02325617,
-0.030878376,
0.025528548,
0.028982563,
-0.0036455442,
0.01947753,
0.005060911,
-0.028203463,
-0.008057205,
0.00018077582,
0.010362046,
-0.036384024,
-0.019204844,
-0.013439495,
-0.016828585,
0.01645202,
-0.009076529,
-0.025944069,
-0.021269463,
-0.0031602292,
0.006547696,
0.031995088,
0.008998618,
-0.0060282955,
-0.0011232042,
0.035760745,
0.020386482,
0.032384638,
-0.0042947954,
-0.0077585494,
-0.0017075301,
0.0072781034,
-0.014374416,
0.019854095,
0.020152751,
-0.0012506197,
-0.0077455644,
0.0018665965,
0.02286662,
0.010199733,
0.003376105,
0.030514795,
0.0015184358,
-0.0056582224,
-0.031319868,
-0.01642605,
-0.0036617755,
0.007979294,
-0.037267007,
-0.04604488,
-0.018919174,
0.036981337,
0.013764121,
0.01736097,
-0.0053822906,
0.00026355532,
0.0012165341,
0.011790398,
-0.017399926,
-0.011387862,
0.0012644163,
0.006262026,
0.005028449,
0.014725013,
0.011524205,
-0.011128162,
0.04178579,
-0.0003536389,
0.016854556,
-0.01989305,
-0.00877138,
0.013971881,
-0.0089726485,
-0.0162962,
-0.02333408,
-0.018438729,
-0.0053530745,
-0.015374263,
0.016724706,
-0.009420631,
-0.013569346,
0.053913802,
-0.007589744,
-0.019217828,
0.001592288,
-0.016477989,
0.018711414,
0.010965849,
0.011835845,
-0.00982966,
0.01151122,
0.020892896,
-0.011043759,
-0.0007072778,
-0.032955978,
-0.010985327,
-0.0022106995,
0.022048563,
0.031190017,
0.0144912815,
-0.0040448336,
0.023035426,
-0.036072385,
-0.014062776,
-0.009991973,
-0.012848677,
-0.0019250292,
0.012030621,
0.020827971,
0.0062068393,
-0.037215065,
-0.013660241,
0.007180716,
-0.004622667,
-0.005288149,
0.008180562,
-0.007297581,
0.0007494791,
-0.009453095,
0.0053920294,
0.0017221383,
-0.023892436,
0.021347372,
-0.03256643,
-0.008518172,
-0.029164353,
-0.037059247,
-0.010504881,
-0.019957975,
0.008349367
] |
Endomitosis in megakaryocytes (MKs) involves repeated DNA replication in the absence of cytokinesis and is a crucial part of MK development. However, chromosomal dynamics have never been observed in living MKs. We developed a new transgenic mouse model in which the expression of human histone H2B fused in-frame to green fluorescent protein is targeted to MKs. Ex vivo time-lapse microscopy analysis indicated that chromosomal condensation occurs at early mitosis in all MKs. In high ploidy MKs (>or=8N), late anaphase was marked by a ring-type alignment of chromosomes with multiple | [
-0.02479772,
-0.002847625,
-0.0030167908,
-0.02538151,
-0.034470025,
0.02018049,
-0.019052718,
0.0064880075,
-0.004209244,
0.009718743,
0.028101431,
0.0035392146,
0.023364788,
0.0074499305,
-0.02106944,
0.007430029,
0.028897505,
-0.011383866,
-0.019503826,
-0.0058975853,
-0.02347093,
0.024810988,
0.010528086,
-0.023616878,
0.012505004,
0.01890677,
-0.009400314,
-0.029162863,
-0.007940844,
-0.008882865,
-0.007920941,
-0.002698361,
0.016253188,
-0.011350696,
-0.024784453,
-0.02430681,
0.013811893,
-0.010594425,
0.020923492,
-0.009048713,
0.0009171442,
-0.0069059464,
-0.014939665,
-0.007894406,
-0.020260097,
0.014515093,
0.01008361,
-0.010800078,
0.0058345627,
0.004660353,
0.025593797,
0.023192305,
-0.015868418,
0.022117604,
-0.023324983,
-0.006952384,
0.01998147,
-0.003071521,
-0.018362785,
-0.01731462,
0.009970834,
-0.007244278,
-0.028605612,
0.008789989,
-0.0062326,
0.008007183,
-0.02061833,
-0.012776996,
0.011403767,
-0.020724474,
0.05821958,
0.013798625,
-0.014170126,
-0.015138684,
0.006703611,
-0.024412952,
-0.025063079,
-0.017460568,
-0.008272541,
0.007403493,
0.028313717,
-0.009592698,
-0.012995916,
0.033992384,
0.01858834,
0.022887142,
0.004229146,
0.008703748,
0.02449256,
0.009261,
0.02887097,
0.03635407,
0.020087615,
0.025262099,
-0.023669949,
0.009340608,
0.011881412,
0.017858606,
-0.0035325808,
-0.023802629,
-0.017035995,
0.008000549,
-0.008073523,
-0.017035995,
-0.027862608,
0.010402041,
0.03481499,
-0.010050441,
0.012087065,
-0.022860607,
-0.01712887,
0.018031089,
0.0076356814,
-0.05139988,
0.025063079,
-0.0057018837,
-0.011350696,
-0.008524631,
-0.0048859073,
-0.005638861,
0.015788812,
0.025646867,
0.013181668,
-0.01509888,
0.013168399,
0.012140136,
-0.009791717,
-0.011722198,
-0.029613972,
-0.0039836895,
0.023550538,
-0.002454563,
0.006670441,
0.014263002,
-0.025607064,
0.012617781,
-0.010594425,
-0.021162314,
-0.015231559,
-0.045774285,
0.0055725216,
0.031099979,
0.0005485451,
-0.0053005298,
0.0071646706,
0.021056172,
-0.009804985,
0.0073902253,
0.0004079882,
-0.005094877,
0.010528086,
-0.006524494,
0.022064533,
-0.0025623648,
0.009314072,
0.01617358,
0.017526908,
0.0012621098,
-0.030118152,
-0.008345515,
0.007589244,
0.0015241511,
0.018230107,
0.015151951,
0.014939665,
0.027968751,
0.004666987,
0.0094401175,
-0.0028625512,
-0.02620412,
-0.005283945,
0.00217262,
-0.036194853,
0.022343159,
-0.021480745,
0.007376957,
-0.0077617266,
0.0064780563,
-0.031444944,
-0.025527457,
-0.016505279,
0.025089616,
0.010262728,
0.010402041,
-0.02759725,
0.015722472,
0.025461117,
-0.017049262,
-0.009486555,
0.021958388,
0.006531128,
0.005230873,
0.014647772,
0.0011932825,
-0.63134015,
-0.014302806,
0.011151677,
-0.034549635,
0.015616328,
0.03953837,
0.017924944,
-0.001099578,
-0.019623237,
0.008478194,
-0.037070535,
0.004361825,
0.01395784,
-0.014435485,
-0.024014914,
-0.041130517,
-0.0013060598,
-0.0037382334,
0.018535268,
0.023311716,
-0.013294444,
-0.016783904,
-0.005506182,
0.019119056,
-0.022024728,
-0.012790264,
0.04325338,
0.004365142,
-0.00080022076,
0.055566,
-0.019954935,
0.010070343,
-0.035823353,
0.008425122,
0.049515836,
-0.0018243374,
-0.013798625,
0.026310263,
0.0024429536,
0.0466765,
-0.019716112,
0.0052010203,
0.009486555,
0.012763728,
-0.023577074,
0.005088243,
0.006411717,
-0.012617781,
0.008889499,
0.000040918025,
-0.0044414327,
0.00060037285,
-0.024983471,
0.0064714225,
-0.010654131,
0.015948026,
0.0051578996,
0.00754944,
0.013566436,
0.008829793,
-0.0022124238,
0.021294994,
-0.017354425,
-0.00697892,
-0.017778998,
0.013161765,
-0.0023948576,
-0.002950451,
-0.0013284493,
-0.0050086356,
0.010335701,
0.012710657,
-0.008451658,
-0.0053469674,
0.01284997,
0.02252891,
-0.0027331891,
0.0022041313,
-0.0074897343,
0.0069192145,
-0.009745279,
-0.014289537,
-0.030993834,
-0.012113601,
0.027199212,
-0.006892679,
-0.03362088,
0.015178488,
-0.008046987,
0.006992188,
-0.009121687,
-0.00113026,
0.0072575463,
-0.029560901,
-0.03433735,
0.020976564,
0.004069931,
0.025713207,
0.007403493,
-0.03476192,
-0.02048565,
-0.022117604,
-0.0047167414,
-0.0044281646,
0.00263368,
0.020578526,
-0.051850986,
-0.0026502649,
0.038423862,
-0.014302806,
-0.0034629242,
-0.014541628,
0.002247252,
-0.025713207,
0.0012156721,
-0.026787907,
0.03160416,
0.00808679,
-0.012670853,
-0.001052311,
0.014621235,
-0.017341157,
0.006109872,
-0.020525455,
0.026681764,
0.003937252,
0.002165986,
-0.011078704,
0.0013723993,
0.00083629286,
0.0021029636,
-0.000505839,
0.03407199,
-0.026867514,
0.031206122,
-0.013241373,
0.010932757,
-0.0055791554,
0.021958388,
-0.020817349,
-0.011735465,
0.01719521,
0.0045973305,
0.0066405884,
0.0014047398,
-0.008551167,
-0.020313168,
-0.007124867,
0.018137231,
-0.0013674238,
0.00023156648,
0.009035446,
-0.026243923,
0.0068993126,
0.012664218,
-0.008896133,
-0.022913678,
-0.02868522,
-0.005711835,
-0.015125416,
0.002875819,
0.01395784,
-0.019464022,
0.0067599993,
0.006070068,
-0.006832973,
-0.0032307357,
-0.01484679,
0.01011678,
-0.02041931,
0.0004697669,
-0.022091068,
-0.026986927,
0.0073305196,
0.0030234247,
0.0023550538,
0.018787358,
-0.012292718,
-0.021308262,
-0.0014926398,
0.017394228,
-0.037150145,
-0.0072376444,
-0.019663041,
0.044235207,
0.025673402,
0.029348614,
0.0069391164,
0.005973876,
0.032824807,
-0.013559802,
0.017274817,
-0.01776573,
-0.0016626348,
0.013665946,
-0.01776573,
-0.015563257,
0.016797172,
-0.005383454,
0.05121413,
0.006444887,
-0.020963296,
-0.011450205,
-0.0069059464,
0.032134876,
-0.030648869,
-0.011383866,
-0.030303903,
-0.005655446,
0.01046838,
-0.004046712,
0.0031710302,
-0.0067931693,
-0.0077749947,
0.020127418,
-0.009055348,
-0.016226653,
-0.0016045877,
-0.016850244,
-0.0019288223,
0.0025159272,
-0.005512816,
0.023497466,
0.008803258,
0.002610461,
-0.0014785426,
0.022953482,
0.026151048,
0.02004781,
-0.0043220213,
-0.0077086547,
0.041157052,
-0.01214677,
-0.0047532283,
0.006083336,
0.0038808633,
0.022926947,
0.005283945,
0.03033044,
0.0063221585,
-0.005204337,
0.004215878,
0.0015589793,
-0.018455662,
0.014727378,
-0.023524001,
0.02239623,
-0.009539627,
-0.021679763,
0.0073371534,
-0.0059241215,
0.008325613,
0.0030864473,
-0.0045442586,
0.008597605,
-0.025607064,
-0.015695935,
0.008849695,
0.03837079,
0.013599606,
-0.00815313,
-0.033780094,
-0.013466927,
-0.026748104,
-0.016996192,
-0.002386565,
0.012219744,
0.015563257,
-0.014050716,
-0.007323886,
-0.014873326,
0.009287536,
0.020697938,
-0.031816445,
0.018628145,
-0.0031826396,
0.026535818,
0.008451658,
0.028101431,
0.008398586,
-0.01363941,
-0.037388965,
0.011224651,
0.011821707,
-0.016783904,
-0.007821432,
-0.027119605,
-0.022581981,
-0.009605966,
0.029322078,
-0.011257821,
0.01306889,
-0.01700946,
-0.010169852,
-0.017327888,
-0.034496564,
0.035849888,
-0.013665946,
0.021056172,
0.012611147,
-0.000977679,
0.014236466,
-0.014183395,
0.0008632433,
0.013566436,
0.0170758,
0.002753091,
-0.0078015304,
-0.017022727,
-0.035292637,
-0.019145593,
-0.021029634,
-0.008491461,
0.00434524,
-0.028658682,
-0.008173032,
-0.015112148,
0.005396722,
0.019968202,
-0.004461334,
-0.018415857,
-0.013135229,
-0.013692481,
0.0050318544,
0.02765032,
0.042085808,
-0.018999645,
0.013918037,
-0.015616328,
0.019052718,
0.0052574086,
-0.020538723,
0.016027633,
-0.021228654,
0.0058544646,
-0.0014644454,
-0.0023583707,
0.01217994,
0.011476741,
0.014594699,
0.009858056,
-0.0034297544,
-0.009639136,
0.012684121,
-0.00651786,
-0.011443571,
0.036141783,
0.045827355,
0.0078347,
-0.0011252845,
-0.01227945,
0.017487103,
-0.014316074,
-0.0056488123,
-0.0033319036,
0.023868969,
0.004756545,
0.022170676,
0.0046139155,
-0.039193403,
0.014010912,
0.009745279,
-0.008935937,
0.006683709,
-0.00850473,
0.024638506,
0.0015050784,
0.001018312,
0.0043187044,
-0.014063983,
0.010541353,
0.0025905592,
-0.022489104,
-0.007556074,
0.037335895,
-0.02018049,
-0.025607064,
-0.007940844,
0.015006005,
0.009645769,
-0.011914582,
-0.029587436,
-0.011337428,
0.007396859,
0.005940706,
-0.034496564,
0.0031660546,
-0.006985554,
-0.004514406,
-0.01278363,
0.0025607063,
-0.016213385,
-0.040679406,
-0.0076224133,
0.009791717,
-0.047127612,
-0.038025826,
-0.01630626,
0.024187397,
0.025580527,
0.0011559665,
-0.014926397,
-0.014369145,
0.016266456,
-0.018827163,
0.00055186206,
0.0018177035,
-0.02474465,
-0.01960997,
-0.007841334,
0.018694483,
0.004849421,
-0.020008007,
-0.003625456,
0.020631598,
-0.029215936,
0.0025922176,
-0.009532993,
-0.026668496,
-0.0074963686,
0.013015819,
0.043492205,
-0.011450205,
0.010879685,
0.0024263689,
-0.03128573,
-0.026111245,
-0.018455662,
-0.008909401,
-0.019172128,
-0.008318978,
0.007158037,
-0.016850244,
0.0038244748,
-0.013354151,
-0.025580527,
0.0062989397,
-0.00091051025,
0.029322078,
0.04375756,
0.0063553285,
0.041157052,
-0.011344062,
0.012193209,
0.012113601,
-0.03736243,
0.024001647,
0.0035193127,
0.00007224791,
0.030781548,
0.008292443,
-0.022183944,
-0.020644866,
0.012438664,
0.00067085866,
0.041793913,
-0.0061563095,
-0.029348614,
-0.0061529926,
-0.0024893915,
0.0031693717,
0.022157408,
0.008995642,
0.011629322,
-0.01580208,
0.012339155,
-0.003275515,
-0.012133502,
0.0016070755,
-0.033328988,
-0.016399136,
0.016226653,
-0.0012364032,
0.0018077525,
0.0025242197,
-0.0058345627,
-0.011801804,
-0.011032267,
-0.008106693,
-0.03653982,
0.00089724234,
-0.01370575,
0.019119056,
0.025806082,
0.035345707,
0.005950657,
0.03791968,
0.006395132,
0.0068661426,
-0.009957566,
-0.020963296,
0.025049811,
-0.008697114,
0.020565258,
-0.007430029,
0.000704443,
0.02340459,
-0.00063188415,
0.03051619,
0.026801176,
-0.021175582,
-0.036513284,
0.018362785,
-0.031630695,
-0.022422766,
0.01801782,
-0.020724474,
-0.014979469,
-0.02702673,
0.005363552,
0.029985474,
0.019556897,
-0.014302806,
-0.0007322227,
0.023961844,
-0.024134327,
0.020896956,
-0.02569994,
0.017858606,
-0.013048988,
0.021401137,
0.0028907456,
0.0026635327,
0.028897505,
0.013997643,
0.017407496,
0.0027381647,
-0.0018359469,
0.0031892736,
0.0071646706,
-0.035849888,
-0.016186848,
-0.008796624,
-0.018283179,
0.0025175856,
-0.00932734,
-0.0038974483,
-0.043226846,
-0.0028907456,
0.015894955,
-0.0066173696,
0.008272541,
0.013785358,
-0.0024495877,
0.027172677,
-0.020379508,
0.03685825,
-0.018044356,
0.013732285,
-0.006103238,
-0.012020726,
-0.03152455,
-0.023762824,
-0.027570715,
0.0067334636,
0.02696039,
0.023324983,
-0.013918037,
-0.007854602,
0.0041230028,
0.009904494,
-0.024651775,
-0.033275913,
0.018946573,
-0.0062060645,
0.0047664964,
-0.0023650047,
0.01243203,
-0.02041931,
0.0027895777,
-0.0060767024,
0.008557801,
0.014395681,
-0.029322078,
-0.030940764,
0.015894955,
-0.011178213,
0.011702295,
-0.021706298,
-0.017460568,
0.0015515161,
-0.022873875,
-0.0100040035,
0.015231559,
-0.0091084195,
0.024466023,
-0.010932757,
-0.0033965847,
0.020989832,
0.014873326,
-0.014833522,
-0.033514738,
-0.016757369,
0.045349713,
0.0016510254,
0.00850473,
0.00598051,
0.007509636,
0.00088480365,
-0.008285809,
-0.0028592343,
-0.017035995,
-0.023723021,
0.0018575073,
0.026124513,
0.014183395,
-0.002033307,
-0.01833625,
-0.032373697,
0.00015766008,
-0.02982626,
-0.03216141,
0.034363884,
-0.046862252,
-0.019583434,
0.011635956,
0.00477313,
0.016982922,
-0.008305711,
0.008000549,
-0.008385318,
0.03481499,
0.011496643,
0.007861236,
0.006570932,
-0.0070187235,
-0.0053469674,
0.00006665051,
0.008517997,
-0.006514543,
0.0013864965,
-0.02910979,
-0.01877409,
0.005814661,
0.022290086,
0.016385868,
0.02150728,
-0.019039448,
0.008796624,
0.010136683,
0.019065985,
0.00019051888,
-0.0052773105,
0.010879685,
-0.024187397,
0.0036884786,
0.0054597445,
0.011184847,
-0.025991833,
-0.0075229043,
-0.018641412,
0.011151677,
-0.010063709,
-0.0067566824,
0.00033377082,
0.016253188,
-0.017526908,
0.016067438,
-0.01157625,
-0.008849695,
-0.01972938,
0.016319528,
-0.0025109518,
0.011702295,
-0.022701392,
0.02284734,
0.00608997,
0.022316622,
-0.023683216,
0.0054265745,
-0.006819705,
-0.0085445335,
-0.040493656,
-0.0033103433,
0.003064887,
0.04447403,
0.019052718,
-0.0044845534,
-0.0023102746,
-0.01598783,
-0.044686317,
-0.032984022,
0.011762001,
0.003129568,
0.015815347,
0.027676858,
-0.002960402,
-0.009532993,
0.0031577623,
0.007828066,
-0.022250284,
-0.0046935226,
0.025262099,
0.0021294993,
0.026920587,
0.0015191756,
-0.0152846305,
0.0077285566,
0.019410951,
-0.005250775,
0.00031221047,
0.016080705,
0.0074432967,
0.014554895,
-0.00044903578,
0.01164259,
0.0017978016,
0.03229409,
0.027252285,
-0.024943668,
-0.0062889885,
0.013719018,
0.008524631,
-0.027066534,
0.003937252,
0.0054232576,
-0.0043220213,
-0.006574249,
-0.026734836,
-0.030224295,
0.0020051126,
-0.03141841,
0.025262099,
0.024810988,
0.016836977,
0.012060529,
0.013473561,
-0.017035995,
-0.008478194,
-0.014594699,
-0.025129419,
-0.024399685,
0.004215878,
0.009771815,
0.007682119,
0.006972286,
0.0037216484,
-0.024704846,
-0.010050441,
0.002908989,
-0.0017082433,
-0.033912774,
0.0049920506,
0.008617506,
0.0041230028,
-0.008743552,
0.020273365,
-0.024346612,
0.0039803726,
0.024213934,
-0.0035889694,
-0.016014365,
0.011987556,
-0.0036553089,
-0.0067467317,
0.0018541903,
-0.007383591,
-0.019968202,
-0.0011227968,
0.0260051,
0.1812927,
-0.0079806475,
-0.0056488123,
0.02392204,
-0.022515642,
-0.022382962,
0.017885141,
0.018362785,
0.00254578,
0.006852875,
0.016571619,
-0.006524494,
-0.0045873793,
-0.0016941461,
0.038768828,
-0.026602156,
-0.009824886,
-0.011204749,
-0.022329891,
-0.012730558,
-0.015191755,
-0.024757918,
0.031949125,
0.013984376,
0.009088517,
-0.0020382826,
-0.009234465,
0.009738645,
0.00197526,
0.008869597,
-0.033169772,
0.006985554,
0.0026187536,
-0.01846893,
-0.008484827,
0.0009511432,
-0.0087103825,
-0.01243203,
0.016531814,
0.0043916777,
0.013334248,
-0.0060037286,
0.0088430615,
0.024014914,
0.00016657445,
0.012233011,
0.004670304,
-0.01370575,
0.020246828,
-0.029162863,
-0.049197406,
0.011808439,
0.0020084297,
0.02189205,
-0.016598154,
-0.005108145,
0.0033783412,
-0.00017745828,
-0.01884043,
0.014156858,
-0.020870421,
0.006972286,
-0.018031089,
0.0016253188,
-0.0065875165,
0.023351518,
-0.017938213,
-0.003323611,
0.010309165,
-0.018216839,
-0.010435211,
0.00022265209,
-0.011317526,
-0.021241922,
0.012385593,
-0.010594425,
0.036699034,
0.0274115,
0.038423862,
0.006126457,
-0.0050351713,
-0.018004552,
-0.017659586,
-0.003156104,
0.0015390774,
-0.016850244,
0.03680518,
0.010581157,
-0.020764276,
-0.027544178,
0.008836427,
0.0028127967,
0.00569525,
0.00093455834,
0.0022754464,
-0.01338732,
-0.005565888,
0.006521177,
-0.018190302,
-0.016213385,
-0.036009103,
0.05779501,
0.033355523,
-0.0057416875,
-0.0067931693,
0.0014039106,
-0.0081133265,
0.015138684,
-0.0070386254,
-0.01826991,
0.012485102,
-0.012717291,
0.018376054,
-0.0034994108,
0.004222512,
0.016783904,
-0.00010521037,
-0.030171225,
0.033275913,
-0.013573071,
-0.005088243,
-0.022197211,
0.028605612,
0.0053502843,
-0.0010904563,
0.008882865,
-0.003645358,
0.011735465,
-0.0031892736,
-0.025248831,
0.0006169578,
-0.013851697,
0.019331343,
0.016266456,
0.009168125,
-0.008717016,
0.0058843177,
-0.011363964,
-0.008219469,
-0.005114779,
-0.0034695582,
0.0008632433,
0.0063155247,
0.012584612,
0.0028608928,
-0.004550893,
0.012644317,
0.031073442,
-0.03717668,
-0.044182137,
-0.008106693,
-0.007025358,
-0.002980304,
-0.0028542588,
0.011350696,
-0.034231205,
-0.005715152,
-0.023603609,
0.0010688959,
0.014488556,
-0.028711755,
0.01592149,
0.0008371221,
0.0013317664,
-0.010262728,
-0.010959293,
-0.16622037,
-0.010687301,
0.022794267,
-0.016836977,
0.02271466,
0.022064533,
0.0054730126,
-0.004010225,
0.0070916973,
0.01275046,
0.015138684,
0.015271363,
-0.047207218,
-0.025222294,
0.020950029,
0.008955838,
0.0069988216,
0.01681044,
0.010806711,
-0.00035864816,
0.019755917,
-0.021281725,
0.017367693,
0.0065278113,
-0.01370575,
0.02328518,
0.012445298,
-0.008663944,
0.0022986652,
-0.036301,
-0.015868418,
-0.013971108,
0.0052972124,
-0.0014843473,
0.004683572,
0.0082460055,
0.0012894749,
-0.009891226,
0.00007867455,
0.00014200808,
0.0210031,
0.010196388,
0.0047266926,
-0.020724474,
0.0038841802,
0.029428221,
-0.008305711,
0.0035723844,
0.011118508,
-0.0030582529,
0.0420062,
-0.020220293,
0.015019272,
0.0160409,
0.015324434,
0.012770362,
0.005582473,
0.006852875,
0.010421942,
-0.0016236603,
-0.001738096,
-0.007828066,
0.02405472,
-0.013811893,
-0.0056255935,
-0.03444349,
0.0011037241,
0.0079143075,
-0.0138915,
0.0014486897,
-0.0074631986,
0.008856329,
0.012962746,
0.0029952305,
0.02982626,
0.012650951,
0.0044480665,
0.013533267,
0.008445024,
0.016956387,
-0.03786661,
0.027544178,
-0.028101431,
-0.027623786,
-0.001096261,
0.011284356,
-0.0011252845,
0.011516545,
-0.010415308,
0.0022771049,
0.0021693031,
-0.020777546,
0.015881687,
-0.012199842,
0.039803725,
0.01986206,
-0.02550092,
-0.023417858,
0.002049892,
-0.005864416,
0.02347093,
-0.0038543274,
-0.020923492,
0.015496917,
0.04688879,
0.0060269474,
0.011629322,
0.0024412952,
0.05190406,
-0.019238468,
-0.008849695,
-0.029613972,
0.0067135617,
0.015642865,
0.015457113,
0.036141783,
0.0043916777,
0.023577074,
-0.006371913,
-0.010627595,
0.08862963,
-0.01915886,
-0.02144094,
0.012929577,
0.011317526,
-0.017845336,
-0.12917636,
-0.022144139,
-0.0053005298,
0.021202119,
0.0012985966,
0.0060435324,
-0.010481648,
0.029030185,
0.001310206,
0.031179586,
-0.031179586,
0.00084209756,
0.008372051,
-0.004680255,
0.0042988025,
0.012524906,
0.009161491,
-0.015404042,
-0.018429125,
0.038025826,
-0.015019272,
0.004517723,
-0.0017132187,
-0.030303903,
-0.007124867,
0.008365417,
-0.03754818,
0.027119605,
0.007536172,
0.015364238,
0.0038443767,
-0.01509888,
0.012080431,
0.007967379,
-0.013692481,
-0.009088517,
-0.018641412,
-0.02398838,
0.04017523,
-0.010760274,
-0.0073504215,
0.017845336,
0.010800078,
-0.0023600294,
0.018137231,
-0.011118508,
-0.002837674,
-0.0027912364,
0.0016750735,
-0.006126457,
-0.040016014,
-0.024917133,
-0.030091617,
-0.002111256,
0.013918037,
-0.019570166,
0.010979194,
-0.0026287043,
-0.028181039,
-0.011244552,
-0.015496917,
-0.0035624334,
0.0059307553,
-0.01345366,
0.015828615,
-0.019079253,
-0.027676858,
-0.02259525,
0.010965927,
-0.018044356,
-0.012577977,
0.0042954856,
-0.025036544,
-0.018110696,
-0.016372599,
-0.009387045,
-0.034470025,
-0.0074831005,
0.0091084195,
0.0046205493,
-0.013188302,
-0.03229409,
0.03558453,
-0.0074831005,
0.037282825,
0.005788125,
0.019464022,
-0.019251736,
0.012889774,
-0.0008698773,
-0.016120508,
0.036884785,
0.00033750242,
-0.017301353,
-0.01142367,
0.011662492,
0.025779547,
0.013221471,
0.03324938,
0.022183944,
-0.023789361,
-0.033275913,
-0.055035286,
0.020777546,
0.0052773105,
0.0064780563,
0.007907674,
-0.016929852,
-0.0010067025,
-0.0047499114,
0.005320431,
0.023019822,
0.0014702501,
-0.00805362,
-0.019291539,
-0.007569342,
-0.038291186,
-0.007104965,
0.020751009,
-0.008882865,
0.0110389,
0.032718662,
-0.0034463394,
0.0013466928,
0.017221745,
-0.0032970754,
0.007589244,
-0.010554621,
-0.014873326,
0.021202119,
-0.006779901,
-0.0050020018,
0.01395784,
-0.03444349,
0.0027746514,
0.0008682188,
-0.0037150146,
-0.02023356,
-0.0038775464,
0.017208477,
0.016598154,
0.034868065,
-0.017235013,
-0.022276819,
-0.012650951,
0.013095426,
-0.00062649406,
0.020764276,
-0.007025358,
0.0008367075,
0.0012579636,
-0.027438035,
0.040493656,
-0.0026369968,
0.010554621,
-0.012073797,
-0.011025632,
-0.0022754464,
0.017367693,
0.0019321392,
0.023590341,
-0.016584886,
0.008146496,
0.017951481,
0.011635956,
0.0022870558,
-0.011695662,
-0.0154173095,
-0.023550538,
-0.006710245,
-0.010010637,
-0.052381705,
-0.0181505,
0.010946025,
0.012067163,
0.0058511477,
-0.0060534836,
-0.0018210205,
-0.014687575,
-0.0078347,
-0.015218291,
0.03383317,
0.0049721487,
-0.004985417,
-0.014170126,
0.0038974483,
0.03202873,
0.0002751018,
-0.010839881,
0.055937503,
0.0012098674,
0.018349517,
-0.009048713,
0.016160313,
0.0019536996,
0.0077882623,
-0.00036548942,
0.018999645,
-0.0138915,
0.010368871,
0.0067898524,
0.036327533,
-0.0018458978,
-0.027384963,
0.0028741607,
-0.018800627,
-0.0033899506,
0.035823353,
-0.021958388,
-0.043359526,
0.010813345,
0.012830067,
0.021294994,
0.009320706,
0.006444887,
0.0077617266,
-0.023709754,
0.011748733,
0.0037581353,
-0.018004552,
-0.004958881,
0.05492914,
0.0074631986,
0.013440392,
0.011251187,
0.0014868351,
0.027809536,
0.0022970068,
0.021494012,
-0.02125519,
0.022727927,
-0.010667399,
0.031126514,
0.015085612,
-0.028101431,
-0.01750037,
-0.010620961,
-0.026084708,
0.015085612,
0.016730834,
0.0065808827,
0.089319564,
0.017022727,
-0.017367693,
0.0220778,
-0.0238557,
0.02430681,
0.02018049,
0.0030217662,
-0.0064183506,
-0.033355523,
0.014541628,
-0.029030185,
0.030648869,
-0.015709205,
-0.01840259,
0.025859155,
0.0033169773,
0.0020349654,
0.0052905786,
-0.01846893,
0.015404042,
-0.018999645,
0.014541628,
0.03261252,
-0.011131776,
0.01884043,
0.032241017,
0.007894406,
0.009937664,
0.00405998,
0.005681982,
-0.017858606,
-0.048189044,
-0.009778448,
-0.00006986383,
-0.008644043,
0.002698361,
-0.019304806,
0.03470885,
0.014316074,
-0.019623237,
-0.014661039,
-0.018177034,
-0.013095426,
-0.00023985891,
-0.008955838,
-0.005844514,
-0.0067135617,
-0.0076091457
] |
Disruption of cell adhesion plays a central role in dedifferentiation, invasion, and metastasis of various cancers. The desmosome and hemidesmosome are anchoring junctions that control cell-cell and cell-matrix adhesion, respectively. To clarify their contributions in mediating the biological properties of oral cancer, we immunohistochemically examined the expression of desmoglein 1 (DSG1), DSG2, DSG3, desmocollin 2 (DSC2), integrin beta 4 (ITGB4), laminin gamma chain 2 (LAMC2), | [
-0.016600104,
0.010504651,
0.020891197,
-0.011882525,
-0.025156047,
0.00366777,
-0.0288435,
-0.0003848616,
0.0037727507,
-0.01618018,
0.02200662,
0.012774862,
-0.002130784,
0.023568211,
-0.025759686,
0.025746563,
0.03125806,
0.004166429,
-0.029053463,
0.014684202,
-0.03989274,
0.008601872,
-0.005859246,
0.0035693503,
-0.019277116,
0.029735837,
0.011042678,
-0.030182006,
-0.0049767504,
0.003009999,
0.019421466,
0.018174818,
-0.01848976,
0.016206425,
-0.011141097,
0.021691676,
-0.0008874166,
0.0043140585,
0.01301763,
-0.0066564446,
-0.01754493,
0.0045141783,
-0.004760227,
-0.027163805,
-0.011869402,
0.006019998,
-0.006567867,
-0.024132483,
-0.018804703,
0.018909683,
0.0076242373,
0.01603583,
-0.014356137,
-0.019277116,
-0.014828551,
-0.0005146524,
0.03301649,
0.021284876,
0.014526731,
-0.0015706125,
-0.006738461,
-0.01754493,
-0.009527016,
-0.012381184,
-0.016101444,
0.019526446,
-0.0014943373,
0.005567268,
0.003940064,
0.014251156,
0.041519944,
0.032885265,
-0.014762938,
-0.023581333,
0.018397901,
-0.038501743,
-0.019040909,
-0.0015091003,
-0.030890627,
0.019880757,
0.0020881356,
-0.017636789,
0.018096082,
0.015747134,
0.0027459064,
0.016495124,
0.004205797,
-0.010386547,
0.006069208,
-0.002637645,
-0.0012679723,
0.012656759,
-0.005245764,
0.0058559654,
-0.031966683,
0.013102927,
-0.011009871,
0.02934216,
0.015589663,
-0.012184345,
0.014054317,
0.00914646,
0.0072174366,
-0.016114566,
-0.021324243,
-0.0206025,
0.03159925,
-0.0052982545,
0.015747134,
-0.0029968764,
-0.03175672,
0.024749245,
-0.010747419,
-0.04619159,
0.02165231,
-0.019106522,
0.006613796,
0.0110558,
0.012033435,
-0.00035205507,
0.0062398016,
0.030733157,
0.030286988,
-0.04141496,
0.030838137,
0.008044161,
0.0059117363,
0.010734296,
-0.0037301024,
-0.004346865,
0.03440749,
0.0056394422,
0.004845524,
-0.0006487491,
-0.0020963373,
-0.009113654,
0.008798711,
-0.022741485,
-0.020340048,
-0.038974155,
-0.0009940378,
0.027898673,
0.008798711,
-0.0043271813,
0.0132407155,
0.015720889,
0.02406687,
0.006659725,
0.0048258402,
0.009376106,
0.0036907345,
-0.010229075,
-0.010727735,
-0.025956526,
-0.002150468,
0.020366292,
0.023633823,
0.024106238,
-0.012669882,
-0.0050620474,
0.0059314203,
0.0011998988,
0.007886689,
-0.007597992,
0.032754038,
0.021954129,
-0.009238319,
0.0057608266,
-0.020090718,
-0.013227592,
-0.003121541,
0.02779369,
-0.015734011,
0.026520798,
-0.027190052,
-0.001377054,
-0.0050981347,
0.030365722,
-0.037766878,
-0.04220232,
-0.023030182,
0.006275889,
0.018227307,
-0.0023046588,
-0.020996178,
-0.012978263,
0.015917728,
0.002617961,
-0.005137502,
-0.024854226,
-0.010648999,
0.014815428,
0.0018978576,
-0.015537172,
-0.6273658,
-0.027190052,
0.039341588,
0.008057283,
0.022990815,
0.02808239,
0.03170423,
0.00096205145,
-0.010432476,
-0.00085214956,
-0.013804987,
0.016901923,
-0.0016304845,
0.0043403036,
-0.021166772,
-0.022728363,
-0.013713129,
-0.014224911,
0.023883153,
0.003638244,
-0.021245508,
0.019487077,
-0.005718178,
-0.008575627,
-0.014762938,
-0.010189707,
0.013660639,
-0.0149072865,
0.018765334,
0.022885835,
-0.03482741,
0.00020104251,
-0.0054655676,
0.013253838,
0.04186113,
0.011219833,
-0.0007180529,
0.025812177,
0.018161694,
0.04934102,
-0.005934701,
-0.00502596,
0.0019388659,
0.015537172,
-0.016573858,
0.000050491297,
0.0074995724,
-0.002422762,
0.0032478464,
-0.010222514,
-0.009264564,
0.007506134,
-0.061046388,
-0.006699093,
0.024604896,
0.0026589693,
0.031494267,
-0.02010384,
0.022019742,
0.008424717,
0.02984082,
0.031520512,
-0.008332858,
-0.018135449,
0.0042123585,
0.0011465881,
-0.026875108,
0.022570891,
0.015550295,
-0.0025490674,
0.008601872,
0.020090718,
0.0016714926,
-0.0044846525,
0.019854512,
0.03005078,
-0.011790667,
0.019880757,
0.004694614,
0.012026873,
0.013352257,
-0.0037727507,
-0.01964455,
0.01768928,
0.021048669,
0.0056197583,
-0.010826155,
0.016311405,
-0.0048684888,
0.0026720918,
0.02502482,
0.018896561,
-0.011961261,
-0.03658584,
-0.009914133,
0.027111316,
-0.007374908,
0.018030468,
-0.009973185,
-0.020195698,
-0.011587266,
-0.0131160505,
0.0022751328,
-0.011016432,
0.030890627,
0.0071387007,
-0.051571865,
0.00909397,
0.032176644,
-0.032596566,
-0.0046454044,
0.0022144406,
-0.0069681066,
-0.0025851545,
0.0007615216,
-0.009408913,
0.00648257,
0.011226394,
-0.001075234,
-0.03251783,
-0.0014533292,
0.0028918956,
-0.008674046,
-0.017886119,
0.040365152,
-0.0069746682,
0.0010776945,
-0.026153365,
-0.009389228,
0.0033019772,
0.0018552092,
0.00638087,
-0.0018224027,
-0.021494837,
0.0076964116,
-0.004064729,
-0.0019142609,
-0.00884464,
-0.0013147217,
-0.034040056,
-0.018214185,
-0.01221059,
0.017374339,
-0.0010186427,
-0.033200208,
0.001848648,
-0.030286988,
0.0037661896,
0.02070748,
0.0022341246,
-0.0013532693,
-0.019382097,
0.0007057504,
0.020983055,
0.01467108,
-0.0056820908,
0.0031838736,
0.0020438468,
0.009579507,
-0.028056143,
-0.014093685,
0.008864325,
-0.012591146,
-0.021284876,
0.0066301995,
-0.015156616,
0.0062988536,
0.013411309,
0.0027213015,
-0.031887945,
-0.020471275,
-0.009920694,
-0.018424146,
0.0041631483,
0.014644834,
0.0076832892,
-0.0076111145,
-0.0045961947,
-0.007250243,
-0.001396738,
0.0061938725,
-0.036060937,
-0.0039269417,
-0.0050948537,
0.042071093,
0.0074339593,
0.043488335,
-0.011593827,
-0.004812718,
0.021442348,
-0.014802306,
0.019828266,
-0.008949621,
-0.0004482192,
0.00010580105,
-0.030077025,
0.025339764,
0.018620986,
-0.00085953105,
0.020681236,
0.026376449,
-0.019355852,
0.01442175,
0.008680607,
0.019670794,
0.0004176681,
-0.013791865,
0.0007529098,
0.01562903,
0.012125293,
0.01447424,
0.011121414,
0.0012901167,
0.010642438,
0.004970189,
-0.009185828,
-0.03262281,
0.007374908,
-0.022833344,
0.0027229418,
-0.021166772,
0.010320934,
0.015852114,
-0.025405375,
0.0015435471,
-0.0004707737,
0.018214185,
-0.0063283793,
-0.0046650884,
-0.025182292,
-0.022898957,
0.0119875055,
0.0069156163,
0.015734011,
0.009691048,
0.0056099165,
0.01411993,
-0.0027590292,
0.042858448,
-0.019920124,
0.0071190167,
0.03684829,
0.013293206,
0.020182576,
0.005183432,
-0.01502539,
0.026507676,
0.0084444005,
-0.003648086,
-0.0004482192,
0.0027426258,
0.0047372626,
0.009061163,
-0.005370429,
0.015589663,
-0.0071190167,
0.01653449,
0.0321504,
0.04235979,
0.0023030182,
0.0038318026,
-0.00316583,
-0.0058100363,
-0.0028328437,
-0.0007898172,
-0.000117693424,
0.002617961,
0.0029821135,
-0.0044748103,
0.004025361,
-0.005130941,
0.010255321,
0.015589663,
-0.04556171,
-0.013778742,
0.020864952,
0.015957095,
-0.004051606,
0.02562846,
0.016626349,
-0.011915332,
-0.041887376,
0.025799055,
0.011147658,
-0.009179267,
-0.017138131,
-0.011403549,
0.014802306,
-0.0050948537,
0.013896845,
0.020431906,
0.017676158,
0.020261312,
-0.0146973245,
-0.0054491647,
0.00009442129,
0.00024912457,
-0.00165837,
-0.0004326361,
0.020064473,
0.00041479754,
-0.010032237,
0.0050423634,
-0.017308725,
0.043094657,
0.014224911,
0.00068524637,
-0.0025753125,
-0.016849434,
-0.031966683,
-0.008982427,
-0.008024477,
-0.021009302,
-0.020983055,
0.017400583,
0.007355224,
0.023502598,
-0.010963942,
0.03159925,
0.007912935,
-0.023476353,
-0.016272038,
0.009966623,
-0.010924574,
0.035536032,
0.026547043,
-0.010124095,
0.024749245,
0.019355852,
-0.008378788,
-0.03270155,
-0.024499916,
-0.011639756,
-0.017610544,
0.00023477172,
0.0020176016,
0.0069221775,
-0.00040557072,
-0.0022193617,
0.04498431,
-0.010215953,
-0.013555658,
0.010110972,
0.009756662,
-0.010977064,
-0.02337137,
0.025654705,
0.034591205,
0.024447426,
-0.0040220805,
-0.017558055,
0.016022708,
0.0055967937,
-0.008811833,
-0.008700292,
0.027347522,
0.016455755,
0.013896845,
-0.019788899,
-0.041441206,
0.0040876935,
0.0031691107,
0.0054261996,
0.0060232785,
0.003260969,
0.037373196,
0.0043599876,
-0.009205512,
0.0024736123,
-0.026665147,
-0.00854282,
0.013424432,
-0.0035398244,
-0.009868204,
0.020681236,
-0.025904035,
0.020445028,
-0.02316141,
0.02024819,
-0.0077029727,
0.012545217,
-0.0016509886,
-0.008470646,
-0.016022708,
-0.013752497,
-0.024972329,
0.011731614,
-0.024709877,
-0.012827353,
-0.02568095,
-0.026205854,
-0.020536887,
-0.023174532,
-0.015484681,
0.01628516,
-0.029053463,
-0.01582587,
-0.0019519884,
0.005009557,
0.01994637,
0.021599818,
-0.025720319,
0.0055246195,
0.023778172,
0.002476893,
-0.0130307535,
-0.0067450223,
-0.02617961,
-0.0057444233,
-0.0011974383,
-0.016062077,
-0.010963942,
-0.012381184,
-0.0018830948,
0.004245165,
-0.0068959324,
-0.017623667,
-0.011121414,
-0.022479033,
0.012269642,
0.022085356,
0.018227307,
0.0006085611,
-0.011777543,
-0.0022538085,
-0.043750785,
-0.018935928,
-0.013975581,
-0.006777829,
-0.010616193,
1.9542952e-7,
0.01336538,
-0.012505849,
0.0024539283,
0.0065514636,
-0.029788328,
-0.010235637,
-0.0068696872,
0.019067155,
0.02200662,
-0.002783634,
0.022032864,
0.0040286416,
0.0034184402,
-0.0031084185,
-0.004300936,
0.0321504,
0.015327211,
-0.018502882,
0.010963942,
-0.0065973927,
-0.012873282,
-0.016875679,
-0.035037372,
-0.0038613284,
0.036270898,
-0.0013950976,
-0.028764764,
0.014749816,
0.0058067557,
0.016022708,
-0.016022708,
-0.0017354654,
-0.016521368,
-0.014461118,
0.017269356,
0.009008673,
-0.029604612,
-0.008477207,
-0.03495864,
-0.02673076,
0.016941292,
0.024814859,
-0.0016796943,
-0.0011728334,
0.0017731929,
-0.007473327,
-0.0017584299,
-0.005163748,
-0.024276832,
-0.015838992,
-0.005787072,
0.041992355,
0.05390769,
0.032465342,
0.012650197,
0.03669082,
0.0048717693,
0.013391625,
0.0026704515,
0.008464084,
0.030418213,
-0.028686028,
0.022898957,
0.009500771,
0.012138416,
0.031835455,
-0.011954699,
0.050968222,
-0.0025966368,
-0.018686598,
-0.03335768,
0.0070402813,
-0.03873795,
-0.029604612,
0.018476637,
0.0050620474,
-0.0149072865,
-0.054852515,
-0.0033790725,
-0.0033118192,
0.005265448,
-0.02030068,
-0.009061163,
0.02955212,
0.014264279,
0.021193018,
-0.0040680096,
-0.01603583,
-0.009015234,
-0.022807099,
0.0020225225,
-0.018620986,
0.022898957,
-0.01447424,
0.015707767,
0.0070205973,
-0.023174532,
-0.007899812,
-0.00082590437,
-0.013673761,
-0.016744452,
-0.0070927716,
-0.039814003,
-0.0055311806,
-0.015720889,
-0.037163235,
-0.032937754,
0.008450962,
0.012131854,
-0.028371086,
0.015471559,
0.0029082987,
-0.016967537,
0.029762084,
0.014999145,
0.020392539,
-0.031336796,
0.010563702,
0.013857477,
-0.009356422,
-0.011141097,
0.006823758,
-0.0069221775,
-0.00231122,
0.023883153,
0.028659783,
0.010773664,
-0.005301535,
-0.02381754,
0.004629001,
0.009192389,
-0.024001256,
0.009382667,
0.015077881,
-0.010977064,
-0.0069812294,
-0.0015337053,
-0.030313233,
0.0028098791,
-0.020589378,
-0.0010514492,
-0.014080563,
-0.012236835,
0.0022718522,
0.030628175,
-0.00040003462,
0.026153365,
0.004760227,
0.0024490075,
-0.009113654,
-0.013673761,
-0.0051539056,
-0.0024752526,
0.0082344385,
0.025352886,
-0.024447426,
-0.0105702635,
-0.00095549016,
0.0043271813,
-0.013778742,
-0.005508216,
-0.021691676,
0.040732585,
-0.014867919,
-0.00718463,
0.020090718,
-0.0038416446,
0.015655275,
-0.011173904,
0.017046273,
0.000547869,
-0.054747537,
-0.013726251,
0.028476067,
0.011127975,
-0.008096651,
0.005632881,
-0.0134638,
-0.0035168598,
-0.025549725,
-0.027557485,
-0.0012581304,
-0.033095226,
-0.024237463,
-0.0039958353,
0.011731614,
0.014106807,
0.004402636,
-0.0017207024,
-0.020182576,
0.0269276,
-0.019618304,
0.03511611,
0.012827353,
0.024106238,
-0.013391625,
0.012722372,
0.0071190167,
-0.048684888,
0.0035004567,
-0.007460205,
-0.010583386,
-0.022951448,
0.0012277843,
-0.008241,
-0.0034643693,
-0.022518402,
0.0012540296,
-0.01281423,
0.037950594,
0.0055967937,
-0.0318617,
0.020326925,
-0.024329321,
-0.01667884,
0.01743995,
-0.017125009,
-0.00016669817,
0.0089430595,
-0.02708507,
-0.0069484226,
-0.0141986655,
0.01125264,
-0.039341588,
0.00442232,
-0.0021275035,
-0.011803789,
-0.0134638,
-0.027400013,
-0.015642153,
0.0146973245,
0.0046355627,
-0.024434302,
0.016337652,
-0.0025474268,
0.0025457866,
0.01356878,
-0.014815428,
-0.012617391,
0.0021570292,
-0.024460549,
-0.007145262,
-0.008168826,
-0.006843442,
0.024460549,
0.008372226,
0.010845838,
-0.01994637,
0.008680607,
-0.030077025,
-0.02215097,
0.022321561,
0.007460205,
0.0028869745,
0.03291151,
-0.014999145,
0.00869373,
0.014684202,
0.0057903524,
-0.0070927716,
-0.0038383638,
0.030313233,
-0.021849148,
0.013168541,
0.02301706,
-0.031940438,
-0.020038228,
0.029788328,
-0.000999779,
-0.010865523,
0.018148571,
-0.008510014,
0.011961261,
-0.016639471,
0.009953501,
0.010366864,
0.007420837,
0.015602785,
-0.015248475,
0.0020569693,
-0.0006844262,
0.0059117363,
-0.011088607,
0.02703258,
-0.021363612,
0.0069681066,
0.013778742,
0.026980089,
-0.004241884,
0.020038228,
-0.0039072577,
0.02035317,
0.006416957,
-0.001984795,
0.039341588,
0.015707767,
0.02090432,
0.0017354654,
-0.009868204,
-0.01642951,
-0.021914762,
0.00929737,
-0.03522109,
-0.029972045,
-0.02341074,
0.0018748931,
-0.036034692,
0.02030068,
-0.0051145377,
-0.008011354,
-0.016337652,
0.037294462,
0.002116021,
-0.009061163,
-0.011679124,
0.007578308,
-0.014382382,
-0.026048385,
-0.005859246,
0.006679409,
-0.015340333,
0.00071518234,
0.0037793121,
0.0056492845,
0.01190877,
0.005783791,
-0.027216297,
0.00012569001,
-0.01075398,
0.20303304,
-0.028712275,
-0.003703857,
0.016744452,
0.012315571,
-0.014815428,
0.012164661,
0.009402351,
0.023555087,
0.030864382,
0.029867064,
-0.011790667,
-0.014881042,
-0.003733383,
0.031573005,
-0.00567881,
-0.020917444,
0.0043239007,
-0.013398186,
-0.00502596,
-0.0025113397,
-0.018778456,
0.016901923,
-0.0038810123,
0.01703315,
-0.015248475,
-0.013411309,
-0.019211503,
0.0013442475,
0.010242199,
-0.016232671,
0.02236093,
-0.015353455,
0.010858961,
-0.0010629315,
-0.007926057,
-0.026980089,
-0.01582587,
-0.00281316,
0.0017436671,
0.017374339,
-0.02763622,
-0.023187654,
0.008956183,
-0.009927256,
-0.016560735,
0.0038449252,
0.00502596,
0.015169739,
0.0055705486,
-0.03823929,
0.004245165,
0.0034643693,
0.015917728,
-0.005386832,
0.004563388,
0.023948766,
0.0060265595,
0.018030468,
0.021114282,
-0.012335255,
0.0003346266,
-0.015865237,
0.03734695,
-0.027714955,
0.022072233,
-0.015642153,
-0.004264849,
0.008116336,
-0.01632453,
0.0020323645,
-0.017964855,
-0.022137845,
0.000748809,
-0.0064530442,
-0.016337652,
0.035273578,
0.004848805,
0.01628516,
0.029604612,
0.0030772523,
0.006712216,
-0.0067515834,
0.014841674,
-0.020891197,
-0.021061791,
0.021429224,
0.009336738,
-0.01562903,
-0.0149072865,
0.0016468877,
-0.012597707,
0.00070616056,
-0.0036251214,
0.022190336,
0.005262167,
0.0066761286,
-0.0033200206,
0.00015931671,
-0.011246078,
-0.029105952,
0.062936045,
0.033436414,
0.008405033,
-0.003270811,
-0.0062463633,
-0.00909397,
0.009756662,
-0.002939465,
0.0034906147,
0.0024293235,
-0.012236835,
0.0045141783,
-0.01743995,
-0.011672563,
0.020274434,
0.02411936,
-0.02667827,
0.015091003,
-0.030759402,
-0.0028115194,
-0.019185258,
0.0053048157,
0.032832775,
-0.01447424,
0.0046847723,
-0.035063617,
-0.004110658,
0.0109048905,
-0.022295317,
-0.00854282,
-0.0010998389,
-0.009527016,
0.011226394,
-0.002844326,
0.006416957,
0.02758373,
-0.0032954158,
-0.031179326,
0.0059675076,
-0.009815713,
0.005337622,
0.0009981387,
0.020221945,
0.00045560068,
-0.031074343,
0.019132767,
-0.00071026135,
-0.0131160505,
-0.012223713,
-0.02673076,
-0.015891483,
-0.0067712674,
0.0050489246,
0.016600104,
-0.01587836,
-0.017466197,
-0.030444458,
0.02010384,
0.0032429253,
-0.024184974,
0.0040680096,
0.0110558,
-0.03658584,
0.00011728334,
-0.00029874445,
-0.16398016,
0.010747419,
0.028371086,
-0.023909397,
0.006672848,
0.008772465,
0.0070009134,
0.012427113,
0.0018601302,
0.00633166,
0.031625494,
-0.010012552,
-0.025339764,
-0.0072174366,
-0.0056853713,
0.013975581,
0.022479033,
0.021140527,
0.0076242373,
0.008464084,
0.014644834,
-0.027767446,
0.010143778,
-0.027400013,
-0.010471844,
-0.009658242,
0.017282479,
-0.0016550894,
-0.02005135,
0.010747419,
0.008523136,
-0.0005417178,
0.025208537,
0.008864325,
0.008096651,
0.026205854,
-0.00016177719,
0.0055443035,
0.013417871,
0.0051145377,
0.029053463,
0.027426258,
-0.010412793,
0.0014516889,
-0.005255606,
0.027058825,
-0.010406231,
0.00042935545,
0.03270155,
-0.005957666,
0.041939866,
0.0050981347,
-0.00336595,
0.029368404,
0.03005078,
0.029604612,
0.019355852,
0.02823986,
0.008549381,
-0.00035861638,
-0.006003595,
-0.017243112,
0.024079992,
0.010937696,
-0.01994637,
-0.030864382,
-0.018096082,
0.021271754,
-0.024959207,
0.017571177,
-0.031415533,
0.003979432,
0.00618075,
-0.0156159075,
0.022400297,
0.020773094,
0.0069615454,
0.0025654705,
-0.022636505,
-0.0071321395,
-0.009677926,
0.0013048797,
-0.022570891,
-0.010524334,
-0.002527743,
0.008076968,
0.0062463633,
0.0031297428,
-0.008201633,
0.0100716045,
0.03351515,
-0.02818737,
0.010379986,
-0.022137845,
0.022977693,
0.03495864,
-0.010478405,
-0.017899241,
-0.0092776865,
0.0001638276,
0.016993782,
-0.022793977,
-0.014395505,
0.02145547,
-0.0020996179,
0.017295603,
-0.007991671,
-0.0027606694,
0.046795234,
-0.008149141,
-0.023633823,
0.0037104185,
0.015353455,
0.022675872,
0.0043206196,
0.035798483,
0.015419069,
0.0031428654,
0.008175387,
-0.017006904,
0.07600617,
0.0004945584,
0.01738746,
0.013503167,
-0.0070271585,
-0.037451934,
-0.12954642,
-0.017125009,
0.0190934,
0.02070748,
-0.004583072,
0.017754894,
-0.008201633,
0.01110829,
-0.029394649,
0.029499631,
-0.019605182,
0.0026540481,
-0.005547584,
-0.014539854,
0.010314372,
-0.013713129,
0.0067253383,
-0.020169454,
-0.010222514,
0.009553261,
0.0039039769,
-0.017912365,
-0.018253552,
-0.01060307,
0.0044124783,
0.012348377,
-0.01743995,
0.034302507,
0.0027295032,
0.026691392,
0.001341787,
0.0031231816,
0.007867006,
-0.011875964,
-0.02175729,
-0.021639187,
-0.0033528272,
-0.031782966,
0.02923718,
-0.024276832,
-0.0013180024,
0.025812177,
0.0069221775,
-0.022269072,
-0.016665716,
-0.007893251,
-0.037110746,
-0.0024375252,
-0.0051539056,
0.0066236383,
-0.01336538,
-0.015156616,
0.0010727735,
-0.027767446,
0.040863812,
-0.005462287,
-0.0012064601,
0.016140813,
-0.01964455,
-0.0032051979,
-0.023909397,
0.0013450676,
-0.021245508,
0.008982427,
0.030260742,
-0.016127689,
-0.02406687,
-0.005852685,
0.030313233,
-0.0062266793,
0.0137393745,
-0.009894449,
-0.027321277,
-0.011685685,
-0.016875679,
0.008496891,
-0.021337366,
-0.014172421,
-0.003552947,
-0.020090718,
-0.0069024935,
-0.01436926,
0.009914133,
-0.013352257,
0.044826843,
-0.014526731,
-0.008798711,
0.009021795,
0.01919838,
-0.020379415,
0.0041270615,
0.04907857,
0.009579507,
-0.0113641815,
0.00678439,
0.016167058,
0.005078451,
-0.0037268216,
0.012860159,
0.027531238,
-0.018804703,
0.010156902,
-0.05684715,
-0.0035299824,
0.0035496664,
0.012630514,
0.036402125,
-0.020379415,
-0.00085953105,
-0.016810065,
0.016757576,
0.0017764735,
-0.0041139387,
0.017768016,
-0.016232671,
0.002632724,
-0.032596566,
-0.03264906,
0.04939351,
-0.01557654,
0.00008119616,
0.04291094,
-0.010124095,
-0.01733497,
-0.00040085477,
0.014986022,
0.0030772523,
0.016757576,
-0.008733098,
0.013752497,
-0.0069156163,
-0.007571747,
0.0032822932,
-0.0513619,
-0.013253838,
-0.005892053,
-0.015143494,
-0.024762368,
-0.019500202,
0.041388717,
0.0017797542,
0.048973586,
0.00075455016,
-0.028659783,
0.027741201,
-0.004527301,
0.0076504825,
-0.001567332,
-0.037661895,
-0.0021389858,
0.000054950935,
-0.029000971,
0.033042736,
-0.00027352443,
-0.0028574488,
-0.015156616,
-0.0067450223,
-0.017676158,
0.017348092,
-0.009435157,
-0.017269356,
-0.03532607,
0.01492041,
0.027478749,
0.0070205973,
-0.0077817086,
0.0067319,
-0.014579222,
-0.03351515,
-0.013752497,
-0.015314087,
-0.0044059167,
-0.025247905,
-0.011127975,
-0.0053080963,
0.009080847,
-0.0072174366,
0.010622754,
-0.025943402,
-0.0008726537,
0.00018320396,
0.013089805,
0.025812177,
0.009933817,
-0.0102815665,
0.028056143,
0.008634678,
0.009080847,
-0.015248475,
0.02488047,
0.009750101,
-0.006462886,
-0.00286401,
0.025431622,
0.022557769,
-0.011449479,
0.002868931,
0.014303647,
0.0059609464,
0.032964,
0.0026360047,
0.028476067,
-0.0064497637,
0.0053737094,
-0.023135165,
-0.0005884671,
-0.027111316,
0.030444458,
-0.0035759117,
-0.04498431,
0.0075586243,
0.00492426,
0.02049752,
0.012243397,
0.017663036,
-0.010517773,
-0.0056853713,
-0.01245992,
0.006144663,
-0.009671365,
-0.0232139,
0.017059395,
0.0026097593,
0.010760541,
-0.016770698,
0.0014549695,
0.019578936,
-0.004714298,
0.021573573,
-0.016114566,
0.016363896,
-0.008510014,
-0.0012745337,
-0.009467964,
-0.034538712,
-0.011121414,
-0.0021045387,
-0.008221316,
-0.00093580625,
0.020878075,
-0.023345126,
0.08052035,
0.029630857,
-0.016508246,
0.007381469,
-0.045246765,
0.028108634,
0.007394592,
0.00025343042,
-0.029053463,
-0.03613967,
0.025851544,
-0.006302134,
0.0057805106,
-0.030890627,
-0.020169454,
0.022584014,
-0.002637645,
0.030024536,
0.0023095796,
-0.00436983,
0.01477606,
-0.025549725,
-0.006561306,
0.018306043,
-0.020864952,
-0.011101729,
-0.017177498,
-0.006600674,
-0.016048955,
-0.016088322,
-0.0016124409,
-0.0060331207,
-0.04065385,
-0.0066400412,
0.016048955,
0.0014451277,
-0.017466197,
-0.025654705,
-0.00036661295,
0.030838137,
0.0021143807,
0.015510927,
-0.022675872,
-0.02568095,
-0.009376106,
0.007191191,
-0.026757006,
-0.0156159075,
0.014014949
] |
Histone/protein deacetylases (HDACs) decrease histone and protein acetylation, typically leading to suppression of gene transcription and modulation of various protein functions. We found significant differences in expression of HDAC before and after stimulation of human T regulatory (Treg) and T effector cells, suggesting the potential for future selective targeting of Tregs with HDAC inhibitors (HDACi). Use of various HDACi small molecules enhanced, by up to 4.5-fold (average 2-fold), the suppressive functions of both freshly isolated and expanded human Tregs, consistent with our previous murine data. | [
-0.026242828,
-0.007731317,
0.023253473,
-0.04195678,
-0.014153138,
0.022724384,
-0.023147656,
0.021904295,
-0.008710132,
-0.003964863,
0.008306702,
0.008392679,
0.027777186,
0.001772449,
0.0046229176,
0.013875366,
0.036903977,
-0.021652978,
0.0070831827,
0.0026454462,
-0.023729654,
0.016745675,
0.0012731211,
-0.01124976,
-0.025779875,
0.009252449,
0.019192712,
-0.038597062,
-0.00093665335,
-0.014655773,
0.01263862,
0.0076982486,
0.0017873297,
0.0021725728,
-0.008128134,
-0.016957311,
0.0011342351,
-0.023306383,
0.011408487,
0.006058072,
0.017922899,
0.021917522,
-0.013306595,
0.013690185,
0.000027978695,
0.009305357,
0.015026135,
0.00080892787,
-0.0032886204,
0.03081945,
0.009040813,
0.01805517,
0.0017691422,
0.02441747,
-0.014801272,
-0.01671922,
-0.006041538,
0.042776868,
0.0065838546,
-0.0120301675,
-0.016256267,
-0.00872336,
-0.032221537,
0.007413863,
0.017287992,
0.033226807,
0.021732341,
-0.0019675507,
0.0047419625,
-0.007036887,
0.038861606,
0.017684808,
-0.016983766,
-0.0019295224,
0.006458196,
-0.02116357,
-0.020224437,
0.005571971,
0.0116994865,
0.0072551365,
0.029655453,
-0.008108293,
-0.003508523,
0.016176904,
0.011712713,
0.000976335,
0.0021957206,
-0.008075225,
0.0060117766,
-0.015105499,
0.025171421,
0.017142491,
0.0266661,
0.021242933,
-0.0017410343,
0.016295949,
0.0031861095,
0.027248098,
-0.0011127408,
-0.005919186,
-0.013240458,
0.0008147148,
-0.011501078,
-0.013339663,
-0.025793102,
0.009159858,
-0.0064085936,
0.0040706806,
0.010482581,
-0.004854394,
-0.02160007,
0.025594693,
-0.0052412907,
-0.043279503,
0.049946025,
-0.019272076,
0.013915048,
0.011474623,
0.018703306,
-0.014946772,
0.027327461,
0.044522863,
0.03573998,
-0.04320014,
0.001334297,
0.0022965781,
0.006335844,
0.00740725,
0.0029480192,
-0.00036994912,
0.011024898,
0.00023788349,
-0.0067392746,
0.011454782,
-0.033755895,
0.00058737176,
0.01706313,
0.0025611226,
0.0037763747,
-0.013782775,
-0.0024817593,
0.008551405,
-0.015343589,
-0.02021121,
-0.009305357,
0.027076144,
0.0085447915,
0.011434942,
0.010879398,
0.020422846,
0.027023233,
-0.016573722,
0.0067062066,
0.0037466134,
-0.0062961625,
0.022671474,
-0.0009788151,
-0.006458196,
-0.019801166,
0.0020072325,
0.001755915,
-0.018174216,
0.02092548,
0.011725941,
0.029972907,
0.013379345,
0.0108397165,
0.011163783,
-0.009245835,
0.008114907,
0.009880742,
0.016362086,
-0.030369723,
-0.016084313,
-0.004732042,
0.013293368,
0.0076585673,
0.014523501,
-0.027142279,
-0.011038125,
-0.00021597589,
0.015541997,
0.02302861,
0.003237365,
-0.008352997,
0.0069972053,
0.019549849,
-0.003650716,
0.012215348,
-0.023160882,
-0.005214836,
0.008458815,
-0.0019906983,
-0.01863717,
-0.63787,
-0.02738037,
0.013663731,
-0.008022316,
0.0053338814,
0.03573998,
0.023822244,
0.007850362,
-0.02140166,
0.0031993366,
0.004255862,
0.028544366,
0.023200564,
-0.04968148,
-0.033623625,
-0.03833252,
-0.012737824,
-0.013676957,
0.034708254,
-0.018332943,
-0.020899026,
-0.002005579,
-0.030845905,
0.004401361,
0.028359184,
-0.012268257,
0.01920594,
0.003225791,
-0.018041944,
0.030660722,
-0.0084125195,
0.005406631,
-0.030210998,
0.014510273,
0.058887634,
0.016877947,
0.0030637574,
0.022684703,
0.0014632625,
0.039205514,
0.0023561006,
0.0020039256,
0.016481131,
0.015343589,
-0.020330256,
0.0106611485,
-0.008630768,
0.013167709,
0.006302776,
-0.013676957,
-0.0017592218,
0.0034126258,
-0.011600282,
0.020806435,
0.029496726,
0.0132867545,
0.029681908,
0.003495296,
0.02513174,
0.019642439,
0.013650503,
0.011415101,
-0.021335525,
-0.0051916884,
-0.014563182,
0.014219274,
0.02183816,
-0.00616389,
-0.0020039256,
0.014430909,
-0.0063556847,
0.01572718,
-0.0033597169,
-0.0000066782018,
-0.009153244,
0.015092271,
0.006025004,
-0.025356604,
0.0088754725,
0.006487957,
0.017274765,
-0.0043517593,
-0.020846117,
-0.0011367152,
0.011759009,
0.017949354,
-0.0020237665,
0.03301517,
-0.0046262243,
-0.0047485763,
0.024311652,
0.0048973826,
0.015489088,
-0.031930536,
-0.021996886,
0.028147548,
0.013194163,
-0.00019851181,
-0.006372219,
0.004771724,
-0.019298531,
0.01514518,
0.0069112284,
0.009569902,
-0.0033894782,
0.00076635275,
-0.03148081,
0.007764385,
0.04642758,
-0.019139804,
-0.008716745,
-0.009305357,
-0.000772553,
-0.017499628,
-0.013928275,
-0.011798691,
0.01404732,
0.007731317,
-0.014497045,
-0.041110236,
0.010634694,
-0.0117061,
0.00819427,
-0.00069773645,
0.011785463,
0.00366725,
-0.008009089,
0.0131148,
-0.007896657,
-0.0022337488,
0.020369938,
0.012261644,
0.01958953,
-0.023266701,
0.020621255,
0.014087002,
0.038808696,
0.0008188483,
0.010204809,
-0.030449087,
-0.018319717,
-0.008776268,
0.008524951,
0.014483819,
-0.021295844,
-0.023174109,
-0.009212767,
0.0036341818,
0.017803853,
-0.00010602453,
-0.0032324048,
0.012360848,
-0.014986454,
0.0076387264,
0.0238487,
-0.017817082,
-0.0053867903,
-0.016679538,
-0.0015790007,
-0.01805517,
-0.0061936514,
0.025065605,
-0.018941395,
-0.0080157025,
-0.030687178,
-0.022962473,
0.0046394514,
0.023663517,
-0.01390182,
-0.029893544,
0.009146631,
-0.00912679,
-0.0087432,
0.0068715466,
0.00006355272,
0.010595012,
-0.004093828,
0.0082141105,
-0.0014277144,
-0.009464084,
-0.0124269845,
-0.018319717,
-0.013200778,
-0.0020717152,
0.051718477,
0.025105286,
0.01304205,
-0.0038458176,
0.008531565,
0.020171529,
-0.014179592,
-0.011091034,
-0.013663731,
0.0035548185,
0.0008436494,
-0.03899388,
0.035792887,
0.007466772,
-0.0060150838,
0.017671581,
0.013941502,
-0.01218228,
0.0024883728,
-0.03645425,
0.006587161,
-0.009232608,
-0.0060448446,
-0.0133528905,
-0.016970538,
-0.011752395,
-0.014735136,
-0.012982528,
-0.008736586,
0.00843236,
-0.011229919,
0.010766966,
-0.017208628,
-0.00460969,
-0.009239221,
-0.03211572,
0.010614853,
-0.004870928,
0.01977471,
-0.014483819,
-0.011878054,
-0.014325092,
0.010409831,
0.008809336,
-0.006729354,
-0.004894076,
0.00554221,
0.0008229818,
-0.006365605,
0.003839204,
0.009781538,
0.023756107,
-0.00958313,
-0.014020866,
0.039866876,
-0.0018319716,
-0.0025065604,
0.005813368,
-0.0069641373,
-0.024047107,
-0.025171421,
0.01349839,
0.018623943,
-0.013366117,
-0.009245835,
0.012175667,
-0.0011557294,
0.018623943,
0.00019613505,
-0.006358992,
0.022261431,
-0.019033987,
0.002926525,
0.018174216,
0.050871935,
0.019100122,
0.0030075419,
-0.011368806,
0.021229707,
-0.031507265,
-0.008908541,
0.010905853,
0.010456126,
-0.004064067,
-0.0027413438,
-0.0262296,
-0.029073454,
0.014721909,
0.014272183,
-0.02006571,
0.0061341287,
0.018650396,
0.0033283022,
-0.004758497,
0.015661042,
0.00072749774,
0.0022271352,
-0.020846117,
0.037380155,
0.00929213,
0.0049502915,
-0.014126684,
-0.028491456,
-0.027076144,
-0.0018981077,
0.011798691,
0.011130716,
0.008710132,
0.017552536,
0.0020287267,
-0.016679538,
-0.0014665693,
0.020965163,
-0.0060382313,
0.01187144,
-0.017922899,
0.00023664343,
-0.02785655,
-0.013240458,
-0.00499328,
0.0058232886,
0.020806435,
-0.024470378,
-0.013055278,
-0.017817082,
-0.03248608,
0.003703625,
0.01263862,
0.018742988,
-0.0148145,
0.0036441023,
0.012632006,
-0.011454782,
0.010866171,
0.016454676,
0.029681908,
-0.026838053,
-0.01944403,
-0.0040177717,
0.013121414,
0.026388327,
0.015105499,
-0.012962687,
0.014166365,
-0.012446825,
0.013848912,
-0.029681908,
-0.01887526,
0.021917522,
-0.003888806,
-0.015303907,
0.0060878335,
-0.013075119,
-0.015475861,
0.01906044,
0.018571034,
-0.0026057647,
-0.012519575,
-0.0346818,
0.000009733124,
0.0063259234,
0.02551533,
0.02699678,
0.02957609,
0.040872145,
-0.005247904,
0.005284279,
0.04066051,
0.010555331,
0.001087113,
0.010098991,
-0.014245728,
-0.00007305979,
0.015925586,
-0.007731317,
-0.02451006,
0.011428328,
0.015952041,
0.016825039,
-0.0066566044,
0.03105754,
0.03148081,
0.008088452,
0.0007411383,
-0.018809123,
0.0060117766,
-0.010277559,
0.0020254198,
-0.018623943,
-0.02474815,
-0.0038292836,
-0.02183816,
-0.01419282,
0.00039867702,
0.004894076,
-0.0203038,
0.008498496,
-0.013743093,
-0.0000074790696,
-0.009272289,
-0.018293262,
-0.0072088414,
0.0019311758,
-0.013134641,
0.0002548309,
-0.02394129,
0.0009250795,
-0.029946452,
-0.004818019,
-0.0043319184,
0.013372731,
-0.032142173,
-0.0132867545,
0.017089583,
0.0071360916,
0.014549955,
0.012724597,
-0.02827982,
-0.0029662068,
0.029073454,
-0.021864614,
-0.00051503535,
0.0017691422,
-0.03158663,
0.014417683,
-0.023187337,
-0.009358266,
-0.014774818,
-0.004232714,
0.01499968,
-0.0073278863,
-0.013458708,
0.035290252,
-0.011329124,
-0.01849167,
0.016732449,
0.0205948,
0.012367462,
0.018544579,
-0.0021494252,
-0.022301113,
0.00023209659,
0.0015079044,
-0.035766434,
0.005046189,
-0.02790946,
-0.006183731,
-0.0015409725,
-0.0076321126,
-0.018888487,
0.0066036955,
-0.0010052696,
-0.018610714,
0.0024486913,
0.028226912,
0.011752395,
0.002701662,
0.019708576,
-0.022393703,
-0.012770892,
-0.016653085,
-0.006560707,
0.029258637,
0.0017013527,
-0.03034327,
0.009860901,
-0.011659805,
-0.017116038,
-0.017235084,
0.0012053315,
-0.021031298,
0.0203038,
-0.011692873,
-0.007559363,
-0.040475328,
-0.014020866,
0.008908541,
0.01562136,
0.0051487,
-0.026216373,
-0.01146801,
-0.0066830586,
-0.011606895,
-0.016123995,
-0.0003104266,
-0.03320035,
-0.012830415,
0.021613296,
0.004027692,
0.0084786555,
-0.0058761975,
0.002410663,
-0.029470272,
-0.00050552824,
-0.01263862,
-0.05198302,
0.009741856,
-0.0001363025,
0.023518018,
0.03899388,
0.046903763,
0.0019940052,
-0.0054992214,
0.017235084,
0.022922792,
-0.0032753933,
0.006977365,
0.030237451,
-0.02365029,
0.010852943,
0.021811705,
-0.022592112,
0.032962263,
-0.009523607,
0.013293368,
0.01834617,
-0.008068611,
-0.048755575,
0.019867303,
-0.033464897,
-0.016600175,
0.0034886824,
-0.01744672,
-0.0008291821,
-0.023914834,
0.002824014,
0.04066051,
0.025541784,
0.019549849,
0.00507595,
0.023200564,
0.014430909,
0.023663517,
0.012043394,
-0.007122864,
-0.002255243,
-0.018901713,
0.0053338814,
0.019483712,
0.037221428,
-0.004120283,
0.035634164,
0.0029033774,
-0.03354426,
-0.002493333,
0.015264225,
-0.033808805,
-0.0026636338,
-0.021150343,
-0.027406825,
-0.017843535,
-0.012598938,
-0.006626843,
-0.044496406,
-0.000873824,
0.016520813,
-0.022234976,
-0.010733899,
-0.0068252515,
-0.0024123164,
0.016137222,
-0.023875153,
0.015370043,
-0.016732449,
0.021573614,
0.03372944,
0.009245835,
-0.016414994,
-0.031110449,
-0.022684703,
0.0052578244,
0.047274128,
0.02909991,
0.0068649333,
0.0004240981,
-0.0062399465,
-0.0045071794,
-0.012274871,
-0.021798478,
-0.022949247,
-0.011315897,
0.0036639431,
-0.0017145799,
-0.0012061582,
-0.01849167,
-0.015872678,
0.010747125,
0.012142599,
-0.008538178,
-0.021229707,
-0.0056017325,
0.0066830586,
0.0061539696,
0.012830415,
0.019086896,
-0.0048147123,
-0.01724831,
-0.01810808,
-0.0015327055,
0.005509142,
-0.016203359,
0.025951829,
-0.0039516357,
0.005300813,
0.019563075,
-0.0022486295,
0.013161096,
0.0011656497,
0.009318585,
0.034232076,
-0.019986346,
-0.016322404,
-0.0036606363,
0.004685747,
0.012632006,
-0.00033068078,
-0.0043848273,
-0.007909885,
-0.01949694,
-0.009669106,
0.018240353,
0.008789496,
-0.031110449,
-0.0050494955,
-0.020105392,
0.0012822148,
-0.01810808,
-0.037776973,
0.038782243,
-0.03306808,
-0.009483925,
0.0018633862,
0.009695561,
0.016428221,
0.0056017325,
0.005357029,
-0.0031828026,
0.024311652,
-0.037380155,
0.01743349,
-0.0048279394,
0.009497153,
-0.011772236,
0.012592325,
-0.030025816,
-0.020171529,
0.015092271,
-0.037009794,
-0.040343057,
-0.012704756,
-0.007936339,
0.02785655,
0.013915048,
0.0027446505,
-0.0067921835,
0.017552536,
0.019007532,
0.0027760651,
-0.017949354,
0.0037234656,
-0.03621616,
-0.008524951,
0.016229814,
-0.017195402,
-0.007678408,
0.0027429971,
-0.009424402,
0.01476159,
-0.015065817,
-0.0015169982,
-0.035845798,
-0.011408487,
-0.012116144,
0.019020759,
0.018451989,
-0.013068505,
-0.01572718,
0.004579929,
0.0054132445,
0.01101167,
-0.021520706,
0.0041764984,
-0.029311545,
-0.009550061,
-0.0008796109,
-0.0024718388,
0.011553987,
-0.043517593,
-0.04399377,
0.017565764,
-0.008855632,
0.029761272,
0.008134748,
-0.012598938,
-0.006203572,
0.0073609543,
-0.06026327,
0.009622811,
0.0006803757,
0.020859344,
0.01701022,
0.0046262243,
-0.023438655,
0.000093727336,
-0.013061891,
0.02116357,
0.001919602,
-0.034417257,
-0.009490538,
0.0047353487,
0.0049006892,
-0.012301326,
-0.030792994,
-0.009755083,
0.034946345,
-0.02160007,
-0.008716745,
0.035581253,
-0.0051718475,
0.027486186,
-0.026930643,
0.021917522,
-0.018213898,
0.0076982486,
0.0208858,
-0.020369938,
0.0103767635,
0.011210078,
-0.005492608,
-0.033914622,
0.01600495,
0.006507798,
-0.007995862,
-0.009080495,
-0.0014301945,
-0.023570927,
-0.0019096816,
-0.0346818,
0.015753632,
0.010118832,
-0.008948222,
0.008227338,
0.011997099,
-0.0063226167,
-0.0065574,
-0.001825358,
-0.0064780368,
0.0035382845,
0.0042591686,
-0.009953491,
-0.0128238015,
0.012764279,
0.0021180105,
-0.020290574,
-0.006983978,
0.0023180724,
0.007195614,
-0.03158663,
0.0035581253,
-0.008749814,
-0.013650503,
-0.0047882576,
0.0005307427,
-0.029840635,
-0.008802722,
-0.003839204,
0.0029116443,
-0.023478337,
0.006917842,
0.011051352,
-0.00187496,
0.008174429,
-0.0068583195,
-0.016322404,
-0.018425534,
0.030316815,
0.19142449,
-0.024682015,
-0.015594906,
-0.0057042437,
-0.00016513372,
-0.007036887,
0.017459946,
-0.020422846,
-0.012724597,
-0.006679752,
0.009225994,
0.010013014,
-0.017380582,
-0.006917842,
-0.00007052801,
-0.027327461,
-0.027168734,
-0.0067227404,
-0.016639857,
0.006749195,
0.015594906,
0.007797453,
-0.005142086,
-0.008233951,
0.035369616,
-0.008921768,
-0.013597595,
0.008101679,
0.01304205,
-0.0052082227,
-0.026533827,
0.00036912243,
-0.0034556142,
-0.002676861,
-0.00052908924,
0.009695561,
-0.025687285,
-0.009847674,
-0.013875366,
-0.008458815,
0.0010077497,
0.005869584,
-0.037036248,
-0.0007378315,
0.005677789,
0.004841167,
-0.0038788856,
-0.012883323,
-0.0034225462,
-0.0033415293,
-0.04261814,
0.01005931,
0.012863482,
0.045660403,
0.010720671,
0.004646065,
0.005836516,
0.01997312,
-0.0059919357,
0.027750732,
-0.015131953,
0.00016720047,
-0.019735029,
0.024205834,
-0.012221962,
0.023703199,
-0.031374995,
-0.0073741814,
0.024801059,
-0.018319717,
0.017274765,
0.015396497,
-0.014325092,
-0.010046083,
0.01106458,
-0.015370043,
0.038491245,
0.025316922,
0.020317027,
0.027248098,
0.013379345,
0.0022320952,
-0.042300686,
0.011917735,
-0.0005910919,
-0.03841188,
0.023663517,
-0.0045667016,
-0.024457151,
-0.0030191157,
0.008571246,
-0.027168734,
-0.020528663,
-0.0046394514,
0.027062915,
-0.0014690494,
-0.0045005656,
-0.011930963,
-0.0032357115,
-0.014616091,
-0.02957609,
0.08952191,
-0.023663517,
0.01925885,
-0.0006398673,
0.018002262,
-0.0061870376,
-0.0031811493,
0.0055818916,
-0.0034456938,
0.029179273,
-0.037644703,
0.015594906,
-0.025092058,
0.001780716,
0.022988928,
0.022420157,
-0.021388434,
0.039655242,
-0.0016872988,
-0.0033448362,
-0.005968788,
-0.0039615557,
0.028756002,
-0.0027198496,
0.007678408,
-0.01834617,
0.006127515,
-0.0006452409,
-0.028782455,
0.004421202,
0.0048841555,
0.011335737,
0.021110661,
0.017750945,
-0.0234122,
0.01935144,
0.0009738549,
-0.008227338,
0.02427197,
-0.011659805,
0.013478549,
0.0012375729,
0.012572484,
0.0025941909,
0.0041169757,
0.0125592565,
0.009933651,
-0.0046923603,
-0.009900583,
-0.00046625992,
-0.009715402,
0.010277559,
-0.012202121,
0.015806543,
-0.013081732,
0.008842404,
-0.015872678,
-0.006454889,
0.023253473,
-0.009087108,
0.000028960403,
0.01786999,
-0.0029496728,
-0.015581679,
0.00052330235,
-0.16571076,
-0.0025181342,
0.023597382,
-0.026322192,
0.03645425,
0.03727434,
0.015475861,
-0.010423059,
-0.0012450132,
0.003020769,
0.005406631,
-0.0024073562,
-0.028861819,
-0.027830096,
0.016309178,
0.007427091,
0.0031117063,
0.026507372,
0.019615985,
0.016467903,
0.010112219,
0.0046592923,
0.0071360916,
-0.009900583,
0.006580548,
0.008683678,
0.014880636,
-0.014100229,
-0.0038259767,
-0.013412413,
-0.024298424,
0.007301432,
0.016309178,
-0.0035217504,
-0.00085150305,
-0.0115606,
0.0022172148,
-0.011461396,
-0.008319928,
0.022340795,
0.023002155,
-0.00038090293,
0.0066830586,
0.0023197257,
0.0045137927,
0.011163783,
-0.007890044,
-0.010171741,
0.004854394,
-0.00064400083,
0.014020866,
0.0007684195,
0.025356604,
0.018941395,
0.031322084,
0.016190132,
0.015925586,
0.020436073,
-0.02451006,
-0.014073774,
-0.0021113968,
-0.0047353487,
0.043173686,
0.01624304,
0.017459946,
-0.026031192,
-0.0011830105,
0.0005927453,
-0.015396497,
0.0017840229,
-0.024708468,
-0.022208521,
0.009503766,
-0.017168947,
-0.013247073,
0.011739168,
-0.009120177,
0.0071890005,
0.009860901,
0.016851492,
-0.026044419,
0.009391335,
-0.026044419,
-0.008729973,
-0.032512534,
-0.027076144,
-0.007446931,
0.013438867,
-0.026547054,
0.00062540005,
0.030925268,
0.008372838,
0.002382555,
0.008538178,
0.022803748,
0.022446612,
-0.008333156,
-0.019338213,
-0.008233951,
-0.0009614544,
0.02738037,
-0.025092058,
0.000052779753,
0.0018187443,
0.031031085,
0.011130716,
-0.043517593,
0.0059820153,
0.03182472,
0.007427091,
-0.0060183904,
0.01977471,
0.00021432248,
0.0015136913,
0.00009026552,
0.036771704,
-0.0043186913,
-0.0049106097,
-0.020330256,
-0.009391335,
0.07391377,
0.008273633,
-0.011276215,
0.0002020253,
-0.013624049,
-0.012744438,
-0.14274828,
-0.017261537,
0.015555224,
-0.006540866,
0.0012607205,
0.011454782,
0.009252449,
0.021732341,
-0.013610821,
0.023901608,
-0.008571246,
0.018518124,
0.0116994865,
-0.025541784,
0.0057075503,
0.027592005,
0.005839823,
-0.018094853,
-0.015264225,
0.053041197,
-0.009715402,
0.014589637,
-0.0016385233,
-0.02661319,
0.02427197,
0.017698037,
-0.0262296,
0.030925268,
0.008934995,
0.012969301,
0.001475663,
-0.0057406183,
0.029205728,
0.016758902,
-0.012790733,
-0.013624049,
0.031930536,
-0.04042242,
0.02780364,
-0.015370043,
-0.00740725,
0.0037069316,
-0.0072419094,
0.008882086,
0.021758797,
-0.03206281,
-0.0025677364,
-0.009999787,
0.0018567727,
-0.0088887,
-0.029443817,
-0.047935486,
-0.020793209,
-0.011891281,
0.023398973,
-0.01294946,
0.030925268,
0.03994624,
-0.03870288,
-0.0051553138,
0.017221855,
0.009397948,
-0.013154482,
0.0040905215,
0.011878054,
-0.026520599,
-0.008862245,
-0.017076356,
0.010509036,
-0.03187763,
-0.004940371,
-0.0062267194,
-0.019311758,
0.010925693,
-0.015502316,
0.031348538,
-0.020991616,
-0.016203359,
0.030263906,
-0.009827833,
-0.016401768,
-0.017221855,
0.011375419,
-0.017817082,
0.035290252,
-0.022036567,
0.009550061,
-0.012671688,
-0.0071890005,
-0.01201694,
-0.0103767635,
0.05714164,
-0.012598938,
0.011653191,
-0.015396497,
0.023676744,
-0.010852943,
0.0068252515,
-0.0049833595,
0.018094853,
-0.010026242,
-0.02421906,
-0.04883494,
0.0022949246,
-0.0040872144,
0.0075130677,
0.010065923,
0.009259062,
-0.018121308,
0.00943763,
-0.011110875,
-0.013319822,
-0.021864614,
-0.016322404,
-0.020713845,
-0.015462634,
-0.0323009,
-0.01328014,
0.040290147,
-0.013716639,
0.0033101146,
0.026732234,
0.00960297,
-0.009133403,
0.0039218743,
0.011177011,
-0.0030935188,
-0.009847674,
-0.00032882072,
0.015952041,
0.000023793516,
-0.0056215734,
0.0008324889,
-0.019073669,
-0.023187337,
-0.0028884967,
-0.021639751,
-0.022869883,
0.0021395048,
0.020026028,
0.0018220511,
0.0018650397,
-0.009457471,
-0.052829564,
0.00033295422,
0.007446931,
0.0042095664,
0.0020154994,
-0.03243317,
0.011990486,
-0.00029120577,
-0.029496726,
0.020740299,
0.016891174,
-0.008425746,
-0.006230026,
-0.017830309,
-0.007876816,
-0.0067855697,
-0.014430909,
0.01600495,
-0.0015938814,
-0.017367356,
0.022565657,
0.01419282,
-0.010403218,
-0.005046189,
0.00835961,
-0.011501078,
-0.012274871,
0.012989141,
0.0029992748,
-0.029020546,
-0.003179496,
0.023253473,
-0.02006571,
0.031665992,
-0.0039086468,
-0.0111241015,
-0.0012640273,
-0.026295736,
0.0094706975,
0.007559363,
-0.021481024,
0.0015302254,
0.02255243,
0.026824826,
-0.0088887,
-0.014589637,
-0.00059605215,
0.00009739583,
-0.010026242,
-0.006041538,
0.0042426344,
0.00043195178,
0.024629105,
-0.001989045,
0.021031298,
0.009014359,
-0.016970538,
-0.011904509,
0.053596742,
-0.001201198,
0.008352997,
-0.014298637,
-0.017856762,
-0.0045931563,
0.026017964,
-0.0177774,
-0.037353702,
-0.0024338106,
-0.0068715466,
0.010429672,
0.00654748,
-0.0057935272,
0.002083289,
-0.019708576,
0.008465428,
-0.0028620423,
-0.0012061582,
-0.019708576,
0.026004737,
0.00056629087,
0.0038358972,
0.021758797,
-0.01390182,
0.020317027,
-0.011038125,
0.018425534,
-0.032856442,
0.0203038,
0.002116357,
-0.00460969,
-0.0035746593,
-0.038729336,
-0.025092058,
-0.00061465293,
-0.0036374887,
-0.00018032436,
0.014946772,
-0.007387409,
0.07788194,
0.016295949,
-0.021322297,
0.009490538,
-0.0093384255,
0.04124251,
0.013584367,
0.025965055,
-0.01887526,
-0.0033001944,
0.006970751,
-0.017208628,
0.012129371,
-0.03277708,
-0.017287992,
0.033650078,
-0.024258742,
0.017671581,
-0.0031943764,
-0.015409725,
-0.0045667016,
-0.010475967,
-0.01218228,
-0.02193075,
-0.039152607,
-0.003945022,
0.03052845,
0.012506347,
-0.01571395,
-0.020224437,
0.016031405,
0.015409725,
-0.037247885,
-0.0045997696,
0.0030141554,
0.00021742262,
-0.028359184,
-0.007856975,
0.028835366,
0.0061010607,
0.003286967,
0.0027413438,
-0.016467903,
-0.014166365,
0.003683784,
-0.00051420863,
0.0010118833,
-0.0021461183,
0.018280035
] |
Inhibition of αvβ3 or αvβ5 integrin function has been reported to suppress neovascularization and tumor growth, suggesting that these integrins are critical modulators of angiogenesis. Here we report that mice lacking β3 integrins or both β3 and β5 integrins not only support tumorigenesis, but have enhanced tumor growth as well. Moreover, the tumors in these integrin-deficient mice display enhanced angiogenesis, strongly suggesting that neither β3 nor β5 integrins are essential for neovascularization. We also observed that angiogenic responses to hypoxia and vascular endothelial growth factor | [
-0.030039104,
-0.030433318,
0.007890849,
-0.023876226,
-0.033508185,
0.010256133,
-0.052246492,
0.00017729362,
-0.024125895,
-0.015939385,
0.013055053,
-0.016688392,
0.0072075455,
0.005814656,
-0.012056377,
-0.00046895037,
0.04622816,
-0.00091736874,
-0.014178562,
0.013225879,
-0.009369152,
0.027568696,
0.0024917608,
-0.0030370902,
-0.022824988,
0.019920945,
0.012108939,
-0.052693266,
-0.0012647698,
-0.019723838,
0.01663583,
0.019960368,
-0.006685212,
0.0102758445,
0.001383034,
-0.004618874,
0.012319187,
0.003866582,
0.015308643,
0.015742278,
0.0077725854,
0.0052660415,
-0.008915806,
0.0030535157,
-0.021024745,
-0.0051839137,
0.008245642,
-0.01689864,
-0.029986542,
0.017949875,
0.006284428,
-0.00046771843,
-0.007358661,
-0.015124676,
-0.021445239,
0.011622742,
-0.008659567,
0.015137816,
-0.005545276,
-0.016819796,
-0.008961798,
0.012575425,
-0.015715998,
0.018475495,
-0.020012928,
0.01131394,
0.00079376623,
-0.007286388,
0.008219361,
-0.012214063,
0.034690827,
0.03017051,
-0.018751444,
-0.013074763,
-0.007641181,
-0.025492502,
-0.01722715,
-0.009789647,
-0.021037886,
0.0037384625,
0.0044184816,
-0.024257299,
0.0022667304,
0.03193133,
0.0076149,
0.01718773,
-0.013048482,
-0.0102758445,
0.021642346,
0.004349494,
0.025623908,
-0.023350608,
0.0064421133,
0.0344543,
-0.004484184,
0.002951677,
-0.019842103,
0.022693584,
0.017923595,
0.00026629976,
0.0035742067,
-0.012779103,
0.0035347852,
-0.02399449,
-0.012450591,
-0.02202342,
0.0059099244,
0.01550575,
0.041445028,
-0.0032062735,
-0.020683093,
0.03137943,
-0.018922271,
-0.033954963,
0.014756743,
0.007030149,
0.028725058,
0.030117948,
-0.021156149,
0.002342288,
0.03164224,
0.0076149,
0.021484662,
-0.019329624,
0.02428358,
0.016320458,
0.031537116,
0.024677794,
-0.03700355,
-0.013626663,
0.0339024,
0.02257532,
0.020446565,
0.0076543214,
-0.013758067,
0.0047897,
-0.017135167,
0.006212155,
-0.039132304,
-0.04825179,
-0.013652944,
0.0049506705,
-0.020959042,
-0.0029681027,
-0.018291527,
0.019842103,
0.03306141,
0.002286441,
0.020985324,
-0.011320511,
-0.018015578,
-0.016806655,
0.0075491974,
-0.028751338,
0.006471679,
0.00026650506,
-0.014796164,
0.03863297,
-0.003022307,
-0.0005576485,
0.023166642,
-0.016727813,
0.009796217,
0.0010881948,
0.052246492,
0.012516294,
-0.009132624,
-0.0013386849,
-0.0027020082,
-0.027463572,
0.023350608,
0.034611985,
-0.017897313,
0.029802576,
-0.012463732,
0.0103546865,
0.005587983,
0.023863085,
-0.027411012,
-0.01802872,
-0.008626715,
0.015663436,
0.0019398612,
0.0050985008,
-0.012733111,
0.011780428,
0.030853814,
-0.029040428,
0.018567478,
-0.02479606,
-0.011123404,
0.0022585175,
0.0034887935,
-0.024086474,
-0.6265374,
-0.026964236,
0.038764372,
-0.0039947014,
0.0018577334,
0.04436221,
0.01722715,
0.0003611575,
-0.005890214,
0.0067246333,
-0.000550257,
0.010932867,
0.009066922,
-0.016110212,
-0.017818471,
-0.016189054,
-0.020367721,
-0.01411286,
-0.0017148308,
0.0036037727,
-0.01297621,
0.0037056112,
0.009270598,
0.009080062,
0.01663583,
0.005788375,
0.03755545,
-0.013127325,
0.011340221,
0.029566048,
-0.00874498,
0.024073333,
-0.010229852,
-0.00662608,
0.04801526,
0.008639856,
-0.0060314736,
0.026937954,
0.026004981,
0.04407312,
-0.014940709,
0.0098882,
0.034585707,
-0.0038337307,
-0.036845867,
0.028593654,
0.009461136,
-0.006488105,
-0.0040242677,
0.0050426535,
0.013416415,
0.012529434,
-0.04578138,
-0.014020877,
0.0035512107,
0.0009165475,
0.02679341,
-0.0064585386,
0.008889525,
0.0025081863,
0.0065702326,
0.017871033,
-0.0100261755,
-0.021208711,
-0.0034329465,
0.02002607,
-0.007555768,
0.0288039,
0.011990675,
0.006432258,
0.03421777,
0.013771208,
0.013784348,
0.01496699,
0.03547926,
0.041313622,
0.018541196,
0.02712192,
-0.00848217,
-0.004996662,
0.00013951478,
-0.010387538,
-0.020196896,
0.02003921,
0.021445239,
0.017450538,
-0.04402056,
0.004428337,
-0.006800191,
-0.0020761935,
0.019277062,
0.012036666,
-0.03164224,
-0.03668818,
-0.011031421,
0.029750014,
0.01553203,
0.028672496,
0.014822445,
-0.011405924,
-0.013219308,
-0.004852117,
0.023219202,
-0.016228475,
0.0065866583,
0.015348064,
-0.041944366,
-0.007936841,
0.021892015,
-0.037897103,
-0.010932867,
-0.004214804,
-0.0073520904,
0.012036666,
0.0052660415,
-0.013810629,
-0.008002544,
-0.012549144,
-0.0066425055,
-0.020394003,
0.019250782,
-0.010334976,
0.0035807767,
-0.011077412,
0.037397765,
0.005821226,
-0.0049769515,
-0.0045301756,
-0.028672496,
-0.0055157105,
0.0038238754,
-0.0035085042,
0.005476289,
-0.02654374,
0.0197764,
0.0026313781,
0.008298204,
-0.010545224,
-0.0058869286,
-0.031458274,
-0.02767382,
-0.010039316,
0.019263923,
-0.008968368,
-0.009237748,
-0.00017472713,
-0.003896148,
0.011524188,
0.018528057,
0.009585969,
-0.010564934,
-0.010624066,
0.00846903,
0.0010668415,
0.031142903,
-0.010919726,
0.015952526,
-0.011359933,
0.009441424,
-0.0014355959,
-0.013810629,
0.016162772,
0.000997854,
-0.0034493722,
-0.006369841,
-0.009415143,
-0.013692365,
-0.00095350505,
0.00018889419,
-0.02848853,
-0.01609707,
-0.031852487,
-0.0077791554,
-0.006800191,
0.006241721,
0.011603031,
-0.0063041383,
-0.017003762,
-0.007871139,
-0.006599799,
-0.0045827376,
-0.02625465,
-0.0036234835,
0.004576167,
0.030380756,
0.020183755,
0.028882744,
0.01666211,
0.009388862,
0.014507074,
-0.014362529,
0.0064782496,
-0.013094474,
0.008153659,
-0.0014101362,
-0.03135315,
0.026990516,
0.01101828,
-0.041445028,
0.02118243,
0.015400626,
-0.0062187253,
0.0058507924,
0.000903407,
0.031983893,
0.008081386,
-0.008692418,
-0.009848779,
0.0018035289,
-0.008271923,
0.004352779,
0.020420283,
-0.007864568,
0.0070104385,
0.018212685,
-0.0053153182,
-0.0052036243,
-0.012095799,
-0.012036666,
-0.042680234,
-0.029145552,
-0.003984846,
-0.006609654,
-0.010091878,
-0.002580459,
-0.0064421133,
0.0104203895,
-0.0036793305,
0.002527897,
-0.026044402,
-0.003978276,
0.02650432,
0.010762041,
0.001995708,
-0.0054105865,
0.005732528,
-0.001212208,
-0.0061595934,
0.02735845,
-0.004375775,
0.022522759,
0.019894665,
-0.0005851614,
0.023534574,
0.021510942,
-0.012102368,
0.030380756,
0.0036760452,
-0.010959148,
0.007063,
0.015545171,
0.006547237,
0.0038205904,
0.0024589095,
0.0040538334,
-0.013810629,
0.017082606,
0.020183755,
0.03306141,
0.026635723,
0.030985218,
-0.006718063,
0.006938166,
0.0013600382,
0.005617549,
0.018514916,
0.023061518,
0.017148307,
0.011248238,
-0.00006231455,
-0.01550575,
-0.002769353,
0.013968315,
-0.030223072,
0.011681874,
0.0076083294,
0.023232343,
0.010216712,
-0.0039191437,
-0.004681291,
0.004027553,
-0.05132666,
0.03947396,
0.010998569,
-0.0025328246,
-0.0028301277,
0.0003841533,
0.012200922,
-0.011524188,
0.023206063,
0.008252213,
-0.013613522,
0.010854024,
0.005246331,
-0.00410311,
-0.0008984793,
0.018055,
-0.014927569,
-0.0023817094,
-0.011530759,
0.018501775,
-0.00054820377,
-0.011419064,
-0.005164203,
0.03161596,
0.004464473,
-0.002698723,
-0.013344143,
-0.028672496,
-0.0042279446,
-0.020157475,
-0.011688444,
-0.000217023,
-0.02651746,
-0.00577852,
0.011143114,
0.016333599,
-0.003554496,
0.022956394,
0.010781752,
-0.013613522,
-0.034112647,
0.01072919,
-0.0023077943,
0.016701533,
0.011156255,
0.0028974726,
0.03327166,
0.0050952155,
0.00028785833,
-0.024191597,
-0.011037991,
0.008620146,
-0.022746146,
0.0029582472,
0.015676575,
0.014717322,
0.0070367195,
0.016189054,
0.041392468,
-0.0058770734,
-0.020262597,
-0.0020269167,
-0.006977587,
-0.009631962,
-0.0069513065,
0.0293558,
0.030669846,
0.032956287,
0.009106343,
0.008981508,
0.005709532,
0.0013206168,
-0.0072995285,
-0.00578509,
0.020078631,
-0.0035742067,
-0.0038271607,
-0.006609654,
-0.042259738,
0.013304722,
0.015847402,
0.01809442,
-0.00040406932,
0.025229694,
0.029014148,
0.013311291,
0.002810417,
-0.015965665,
-0.044861548,
-0.0056701107,
0.0103415465,
0.00023858158,
-0.016478144,
-0.0040209824,
-0.0344543,
-0.00959254,
-0.02599184,
0.012989351,
0.0036267685,
0.01297621,
-0.0020170615,
0.00083852594,
-0.021445239,
-0.014244265,
-0.035374135,
0.006918455,
-0.01834409,
-0.008377046,
-0.022128545,
-0.007936841,
0.0044743284,
-0.019237641,
-0.024401844,
0.0304596,
0.004852117,
-0.016018227,
0.0000029274108,
0.01696434,
0.03274604,
0.013508399,
-0.01802872,
0.016215334,
0.017568802,
0.0007954088,
-0.023534574,
0.0016105283,
-0.019277062,
0.018817147,
-0.013994596,
-0.029487204,
-0.027437292,
0.0062975683,
-0.0076674614,
0.014296827,
-0.009539978,
0.008081386,
-0.01835723,
0.017003762,
-0.018672602,
-0.0007991046,
0.0029812432,
0.008061675,
-0.014244265,
0.01605765,
-0.020394003,
-0.015886823,
-0.021589784,
-0.028330844,
0.00422466,
-0.008140518,
-0.002974673,
-0.016044509,
-0.009737085,
0.008403327,
-0.008403327,
-0.0055255657,
-0.005420442,
0.029513486,
0.011543899,
0.0055157105,
0.0066655013,
0.018160123,
-0.006852753,
-0.024125895,
-0.0035315,
0.011681874,
-0.00959911,
-0.008935517,
0.014047158,
-0.0010849097,
-0.007733164,
-0.023849946,
0.011511047,
0.0041950936,
0.020840779,
0.023271764,
-0.014047158,
-0.01551889,
-0.024730356,
-0.023048377,
-0.004681291,
-0.0208802,
-0.005019658,
-0.024993166,
0.020827638,
0.013942034,
-0.031694803,
0.0015826048,
-0.03137943,
-0.016478144,
0.02541366,
0.0066556456,
-0.0037023262,
-0.010242993,
0.0018396652,
-0.021642346,
-0.018725164,
-0.043416098,
-0.042207174,
-0.021090448,
-0.030564724,
0.04060404,
0.050564513,
0.021366397,
0.01553203,
0.019303344,
0.025794733,
0.0028481958,
0.025190273,
0.0020696232,
0.03692471,
-0.017897313,
0.02400763,
-0.000060825983,
0.019723838,
0.039053462,
0.004428337,
0.033140253,
-0.0032210567,
-0.03130059,
0.001966142,
-0.008140518,
-0.03300885,
-0.02511143,
0.02114301,
-0.0106569175,
-0.0015357919,
-0.03526901,
-0.0056274044,
0.004342924,
0.008436179,
-0.000368549,
-0.0032391248,
-0.005640545,
-0.00030695306,
0.029723734,
-0.0032095588,
0.011103693,
0.0033409633,
-0.0008689133,
0.026570022,
-0.022443915,
0.020959042,
0.00422466,
-0.00029032215,
0.018081281,
-0.026425475,
-0.010854024,
-0.0022092408,
-0.014809305,
-0.0044349073,
-0.009710804,
-0.019277062,
-0.015058974,
-0.012805384,
-0.01919822,
0.002077836,
0.00013427914,
0.002107402,
-0.0350062,
0.0033458911,
-0.007825147,
0.007857999,
0.014599057,
-0.021313835,
0.02680655,
-0.021090448,
0.015571452,
0.011195676,
0.0067246333,
0.0012516293,
-0.022667304,
-0.009513697,
0.018055,
0.016149633,
0.010190431,
-0.0061957296,
-0.012352037,
-0.0052988925,
0.003896148,
-0.015939385,
-0.024782918,
0.051536907,
0.004720712,
-0.005528851,
0.004815981,
-0.023757963,
-0.03810735,
0.0019562868,
0.0017460394,
0.003610343,
0.01015101,
-0.016570127,
-0.0015489324,
0.030853814,
0.005729243,
0.022181105,
-0.0019989933,
-0.014888148,
0.002669157,
-0.0025262544,
-0.0075754784,
0.008265353,
-0.004007842,
0.03130059,
-0.0029713877,
-0.006938166,
0.027542416,
-0.007831718,
-0.01101171,
0.0024490543,
-0.010019605,
0.04483527,
0.00063936575,
-0.015203519,
0.029802576,
0.002721719,
0.010321836,
-0.01579484,
0.00045293543,
-0.00987506,
-0.0355581,
-0.0017575372,
0.025912998,
0.0037351772,
-0.013915753,
0.011938113,
-0.016307319,
0.0057653794,
-0.024125895,
-0.039368834,
-0.0102495635,
-0.034349177,
-0.018554337,
-0.013784348,
0.015742278,
0.011405924,
-0.013127325,
-0.0009855349,
-0.0029434643,
0.019001113,
-0.034296613,
0.023350608,
0.008567584,
0.013094474,
-0.013652944,
-0.008554443,
-0.002725004,
-0.029145552,
-0.0000677042,
-0.030039104,
-0.037029833,
-0.008580724,
-0.0026330207,
0.011832989,
0.012194352,
-0.010926297,
0.014914429,
-0.012529434,
0.033665873,
-0.0054073017,
0.003413236,
0.00904721,
-0.025794733,
0.00423123,
0.0045038946,
0.0020959042,
-0.02172119,
0.0050623645,
0.0005490251,
0.00038497458,
0.0028761195,
-0.01583426,
-0.028252,
0.016031368,
-0.002030202,
-0.012306046,
-0.0012672336,
-0.04089313,
-0.024231018,
0.009158905,
0.0017641075,
-0.013876332,
0.0014930854,
0.005512425,
-0.017713347,
0.008823822,
-0.027437292,
-0.009126053,
0.009921052,
-0.023008956,
-0.027253326,
0.0014355959,
-0.0054828594,
0.017555661,
0.0066917823,
-0.0019152228,
0.00024371457,
-0.011438775,
-0.041313622,
-0.01833095,
0.021576645,
0.012010385,
0.0022683728,
0.0007477746,
-0.017660785,
0.009645102,
-0.005732528,
0.007227256,
0.0030699412,
-0.008035394,
0.0051116413,
-0.008817253,
0.010939438,
0.0203283,
-0.023744822,
-0.032272983,
0.02262788,
-0.006859323,
-0.02566333,
0.03182621,
-0.009158905,
0.025978701,
-0.02174747,
0.0040833997,
0.010571505,
-0.00844932,
0.038475282,
-0.014086579,
-0.033087693,
-0.009980184,
0.0028383406,
0.0040209824,
0.013705506,
-0.007930271,
0.013587241,
-0.005397446,
0.0004194683,
-0.019553013,
0.0033968103,
0.008331055,
0.024375563,
0.03810735,
0.025623908,
0.020433424,
0.0104598105,
0.011951254,
0.0103152655,
-0.0025886716,
0.003007524,
-0.0021665343,
0.016031368,
-0.0038567267,
-0.028173158,
0.0016721243,
0.002301224,
-0.039027184,
-0.0034099508,
0.026688285,
-0.00009023804,
-0.0028350553,
0.0064158323,
-0.0057456684,
0.008377046,
-0.00055313145,
0.011077412,
0.0036497642,
-0.032430667,
0.0073849414,
-0.004540031,
-0.008140518,
-0.025558205,
0.01071605,
0.008955227,
-0.0062187253,
-0.0063402746,
-0.008830393,
-0.010762041,
-0.005423727,
0.19731723,
-0.012181211,
-0.011031421,
0.021300694,
0.008048535,
-0.0101707205,
0.003442802,
-0.0049506705,
0.0030584433,
0.017634505,
0.025715891,
0.010518943,
-0.026714567,
-0.0041918084,
0.014612198,
-0.028567372,
-0.010913157,
-0.008107667,
-0.020512266,
0.007936841,
-0.0060019074,
-0.01722715,
0.030249352,
-0.005702962,
0.040262386,
0.014020877,
-0.029040428,
0.015584592,
0.00019228196,
-0.0028481958,
-0.025282256,
-0.010985429,
-0.0043626344,
0.0003933927,
0.012536004,
-0.012673979,
-0.018370371,
-0.001992423,
0.001918508,
0.013350713,
-0.024257299,
0.01806814,
-0.011832989,
0.009566259,
-0.0068461825,
0.016543847,
0.010617496,
0.008252213,
-0.0019349336,
0.012260054,
-0.03815991,
-0.002524612,
0.015361204,
0.027016798,
-0.017647645,
-0.00029011685,
0.0310115,
0.0030387326,
0.007562338,
0.025190273,
-0.010702909,
0.01551889,
-0.008285063,
0.0102364225,
-0.01583426,
0.030328194,
-0.024047052,
0.0074046524,
-0.024296721,
0.0073849414,
0.004198379,
-0.013048482,
-0.023836805,
0.025637047,
-0.013863191,
-0.022719866,
0.01831781,
0.007141843,
0.01327187,
0.00082251104,
0.018265247,
-0.013810629,
-0.0033803848,
-0.007483495,
-0.029224396,
-0.013797489,
0.010426959,
0.021997139,
0.007641181,
-0.015991947,
-0.0023028667,
-0.027463572,
-0.011228528,
-0.000398731,
0.020709373,
-0.001474196,
-0.00820622,
0.007871139,
-0.011425635,
0.00791713,
-0.026136385,
0.066701,
0.023035236,
-0.010045886,
-0.0033836698,
-0.012352037,
-0.0037680285,
0.0072338264,
-0.02174747,
0.010683198,
-0.025571346,
-0.011274519,
-0.002107402,
-0.013127325,
0.0048422613,
0.009907911,
0.025058867,
-0.037476607,
0.0052397605,
-0.0058048004,
-0.0053186035,
-0.022995815,
-0.0065899435,
0.034638267,
-0.014572776,
0.0029943837,
-0.023100939,
0.015453188,
0.007674032,
-0.022102263,
-0.017332274,
-0.0025870292,
0.011340221,
-0.0017493245,
0.009211467,
0.001792031,
0.009546548,
-0.010676628,
-0.006126742,
0.025190273,
-0.028462248,
-0.01241774,
0.02289069,
0.0070432895,
-0.0020614106,
-0.0055485615,
0.021208711,
-0.007371801,
-0.0058770734,
-0.017634505,
-0.02229937,
-0.013344143,
-0.005364595,
0.0016253113,
0.025190273,
-0.015019552,
0.010242993,
-0.053981032,
0.012187782,
0.0106043555,
-0.018409792,
0.0010487734,
0.020012928,
-0.03384984,
-0.003286759,
0.0037023262,
-0.16336226,
0.012016956,
0.02114301,
-0.037029833,
0.008133948,
0.003528215,
-0.0015875325,
-0.01890913,
-0.0041392464,
-0.0029056855,
0.044493616,
-0.00930345,
-0.033823557,
0.004618874,
0.0019250782,
0.008561013,
-0.010098448,
0.023771102,
0.0068724635,
0.014467653,
0.02455953,
-0.034874797,
0.021957718,
-0.015374345,
-0.003334393,
0.016333599,
-0.0052693267,
-0.02909299,
0.013166746,
0.006018333,
0.014060298,
0.0020712658,
0.030144228,
-0.012010385,
0.039316274,
0.009697664,
0.005479574,
0.0074572144,
0.000685768,
0.022470197,
0.034322895,
0.020853918,
0.002215811,
-0.012490013,
-0.007358661,
0.010775181,
0.008225932,
0.008383617,
0.025137711,
-0.010808033,
0.023560856,
-0.018830286,
0.008179939,
0.014244265,
0.013521539,
0.021340117,
0.008580724,
0.019842103,
-0.012739682,
-0.013955174,
-0.006971017,
-0.015624014,
0.029566048,
-0.0037581732,
-0.016399302,
-0.043363538,
0.0026067398,
0.004917819,
-0.019079955,
-0.0021484662,
-0.041865524,
-0.009369152,
0.02116929,
-0.031537116,
0.027437292,
0.027148202,
-0.013403275,
0.019553013,
0.009053781,
0.022128545,
-0.00606104,
-0.0060741804,
-0.031248027,
-0.02090648,
-0.013140465,
0.03745033,
0.03392868,
0.010709479,
0.018961692,
0.002992741,
-0.0029796006,
-0.033429343,
-0.0065373816,
-0.020630531,
0.0060577546,
0.01356096,
0.02371854,
-0.01754252,
-0.0055584167,
0.018501775,
0.03329794,
-0.020683093,
-0.023022095,
0.0031110053,
0.007844858,
0.013186458,
-0.009218036,
0.005890214,
0.05865904,
-0.0042542256,
-0.00678048,
-0.0033245378,
-0.008370477,
-0.00096336036,
-0.017831612,
0.0058573624,
-0.012463732,
0.0074112224,
-0.006455254,
-0.045282044,
0.057239868,
0.01354782,
-0.012352037,
0.00903407,
0.013955174,
-0.019671276,
-0.13834283,
-0.028173158,
0.025479363,
0.01271997,
-0.009651672,
0.011320511,
-0.021326976,
0.017700206,
-0.015637154,
0.021524083,
-0.03808107,
0.0058343667,
-0.0025213268,
-0.020354582,
0.018002437,
-0.011701585,
0.011767287,
0.013705506,
-0.01270683,
0.0412085,
-0.015098395,
0.0010192074,
0.017621364,
-0.0010167435,
-0.00035150745,
0.015321783,
-0.0366619,
0.004967096,
0.0049506705,
0.014704181,
0.009231177,
0.003991416,
0.017161448,
-0.01158989,
-0.031510837,
-0.017621364,
0.0005182271,
-0.011182536,
0.010821173,
-0.014704181,
-0.0038173052,
0.010886876,
0.028462248,
-0.005814656,
-0.02819944,
0.0024901181,
-0.03135315,
0.0045958776,
0.017923595,
-0.025229694,
-0.03497992,
-0.0063107084,
-0.0024786203,
-0.01718773,
0.033455625,
0.0011169396,
0.015755419,
0.015702857,
-0.016990623,
0.013219308,
-0.018278388,
0.012227203,
-0.00874498,
0.023074657,
0.006911885,
-0.01999979,
-0.015663436,
-0.030275632,
0.007674032,
-0.021892015,
0.0037450327,
-0.0012048164,
-0.016044509,
-0.019815821,
-0.03277232,
0.0002494635,
-0.009060351,
-0.019040534,
0.024112754,
-0.020538548,
-0.023600277,
-0.010880305,
0.030958937,
0.009329731,
0.005817941,
0.0043396386,
-0.017266572,
-0.008541303,
0.026004981,
-0.007930271,
-0.003227627,
0.042180896,
0.018396651,
-0.018133843,
-0.00085495156,
0.010321836,
0.011169395,
-0.023534574,
0.03195761,
0.00016569305,
-0.019671276,
-0.00095596886,
-0.042680234,
0.018685741,
-0.01946103,
0.012266625,
0.023757963,
-0.0013000848,
0.001009352,
-0.025505643,
0.0010849097,
-0.01612335,
-0.0022897262,
0.006235151,
-0.0017164733,
0.00986849,
-0.004704287,
-0.026057543,
0.046964023,
-0.015072114,
-0.00019741496,
0.037765697,
-0.002089334,
0.004241085,
0.0041589574,
-0.0005243867,
0.00162449,
-0.022102263,
-0.012194352,
0.02231251,
-0.0017756054,
0.00932316,
0.028357124,
-0.04294304,
-0.0034592275,
-0.010801462,
-0.0100261755,
-0.031169184,
-0.0010816245,
0.037371483,
0.0017788905,
0.029276958,
-0.021234993,
-0.03729264,
0.03356075,
-0.008225932,
0.009697664,
-0.0046747206,
-0.034060087,
-0.0030058816,
-0.0031816352,
-0.0050327983,
0.0050886455,
0.00021168469,
-0.024612091,
-0.03471711,
-0.009211467,
-0.02174747,
0.005844222,
0.0023817094,
-0.020249458,
-0.030091666,
0.008652996,
0.01754252,
0.0018807291,
0.014848726,
0.025939278,
-0.012956499,
-0.03017051,
0.010492662,
0.005587983,
-0.035111323,
-0.023416309,
-0.023613416,
-0.008048535,
-0.009940762,
0.008212791,
0.007857999,
-0.017700206,
0.0001474196,
-0.0038501564,
0.032036453,
0.03450686,
-0.0066720713,
-0.02479606,
0.004635299,
0.014126,
-0.008311344,
-0.017292853,
0.026964236,
0.024467546,
-0.026964236,
0.00058228686,
0.023087798,
0.016451864,
-0.0022634452,
0.013396705,
0.042785354,
-0.009934192,
0.010256133,
-0.0065636626,
0.030564724,
0.00037717243,
-0.011169395,
0.004066974,
-0.007680602,
-0.010939438,
0.03253579,
-0.038554125,
-0.041918084,
-0.017397976,
0.008232501,
0.0045564566,
0.022378214,
0.007562338,
-0.0063665556,
0.0033376783,
-0.008114237,
0.020236317,
0.004740423,
-0.020485986,
0.037397765,
0.015006412,
0.009434855,
-0.016202195,
-0.019106237,
0.019369045,
-0.0061070314,
0.04060404,
-0.034244053,
0.018488634,
-0.014441372,
0.021878876,
-0.009218036,
-0.03508504,
0.007536057,
0.017082606,
-0.007969692,
-0.00310772,
0.012279765,
0.014034017,
0.07747618,
-0.0010052456,
-0.012522863,
0.003777884,
-0.03408637,
0.019237641,
0.0056799664,
0.019421607,
-0.024625232,
-0.025768453,
-0.0025032586,
-0.015085255,
-0.0052331905,
-0.042233456,
-0.025939278,
0.01356096,
-0.017713347,
-0.0033327506,
-0.0035972025,
0.003892863,
0.008856674,
-0.026635723,
0.005252901,
0.021392677,
-0.042154614,
-0.0016918349,
-0.006258147,
0.030012824,
-0.0065603773,
-0.025794733,
-0.00014670097,
0.01411286,
-0.04042007,
-0.0019119377,
0.011202247,
-0.0035315,
-0.009447995,
-0.018225826,
0.010210142,
0.031458274,
0.004204949,
0.003416521,
-0.02822572,
-0.022417635,
0.014034017,
-0.011215387,
-0.03392868,
-0.007030149,
0.010959148
] |
Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in | [
-0.026314076,
-0.0045207064,
-0.017992087,
-0.030306557,
-0.0124181695,
0.010603406,
-0.016721753,
0.007077579,
-0.0098126875,
-0.010396005,
0.032691676,
-0.01142005,
0.010635813,
-0.0012225352,
-0.02882882,
0.004293861,
0.026625179,
0.01341629,
-0.0036846187,
0.0044332086,
-0.023773406,
0.013163519,
0.010331191,
-0.025601134,
0.008652534,
0.023241939,
0.028102914,
-0.02947695,
-0.0129885245,
0.00012739805,
0.0056354897,
-0.01775876,
-0.0006339521,
-0.006993322,
-0.023164164,
-0.009683061,
0.014245897,
-0.021673465,
0.019405011,
0.017564321,
0.0044267275,
0.021090148,
-0.003765635,
0.009060857,
0.010545074,
0.003645731,
0.008386802,
-0.020312393,
-0.017771723,
0.024564125,
0.034091637,
-0.0162551,
0.011095985,
-0.0026362685,
-0.0394063,
0.0056095645,
-0.018342078,
0.027273308,
0.010609888,
-0.014427372,
0.0034545327,
-0.0056387307,
-0.004015165,
-0.007246093,
-0.00083284697,
0.024810415,
-0.0052952217,
-0.005820207,
-0.001785598,
0.015684744,
0.030099155,
0.027065907,
-0.000738058,
0.009112707,
0.027636262,
-0.008121069,
-0.0260289,
0.012709828,
0.005172077,
-0.016968042,
0.0067405514,
-0.017305069,
-0.012832973,
0.037669312,
0.012683903,
-0.0031013018,
0.007634971,
0.009404366,
0.0141162705,
-0.009715468,
0.022866024,
0.03515457,
0.02888067,
0.022075307,
0.0032633343,
0.010927471,
0.01221725,
0.031239863,
-0.0056128055,
-0.0020983208,
-0.029762127,
0.01221725,
-0.010739514,
-0.023254903,
-0.025497433,
0.019379085,
0.022166044,
0.019495748,
0.015231053,
-0.010979321,
-0.019145759,
0.016099548,
-0.004822087,
-0.05361331,
0.011167279,
0.0012136233,
-0.002334888,
0.0016081724,
-0.008347914,
0.014971802,
0.018666143,
0.027247382,
0.007939592,
-0.024758564,
0.026145563,
0.022801211,
-0.01541253,
-0.011983923,
-0.018134676,
0.00053430215,
0.02378637,
-0.0054054037,
0.015192166,
0.015956959,
-0.023993772,
0.0005104023,
-0.035699,
0.013202407,
-0.01746062,
-0.028465867,
-0.00028396194,
0.039458152,
0.011783003,
-0.010460817,
0.013286664,
0.0114719,
0.033028703,
0.0051688366,
-0.0016494907,
-0.00065299094,
-0.008743273,
-0.032458346,
0.034610137,
-0.013688505,
0.0006270657,
-0.004105903,
-0.007557195,
0.028284391,
-0.01017564,
-0.00053146656,
0.0030543124,
-0.019379085,
0.021271626,
-0.0019427695,
-0.00028274668,
0.017940236,
0.0019589728,
0.01935316,
0.012606127,
0.0076479334,
-0.0013878082,
0.020182766,
-0.019456862,
0.0053081843,
-0.014181083,
0.013688505,
0.006552594,
0.008808086,
-0.052446675,
-0.024201171,
-0.0006687891,
-0.0053600348,
0.020779045,
-0.0048642154,
-0.003321666,
-0.0037915602,
0.024719676,
-0.022658624,
-0.0068507334,
-0.017175443,
-0.004008684,
0.020312393,
0.011128391,
-0.010039533,
-0.63755244,
-0.0142329335,
0.023617856,
-0.011698745,
0.0071164668,
0.009546954,
0.0071488735,
-0.03087691,
-0.017421734,
0.006060015,
-0.0065817595,
0.0012192945,
0.014919952,
-0.0067664767,
-0.00020254061,
-0.021803092,
0.00523689,
-0.019392049,
0.015503269,
0.006627129,
-0.02019573,
-0.007142392,
-0.0028906595,
0.015982885,
-0.029684352,
0.0020075825,
0.029243624,
0.019729076,
-0.0020821174,
0.04464319,
-0.009961757,
0.007356275,
-0.012956117,
0.004079978,
0.048791222,
0.027662186,
-0.022347521,
0.031991694,
-0.0024515516,
0.016203249,
-0.009611767,
-0.009488623,
0.007278499,
0.006539631,
-0.018756881,
0.024356723,
-0.0034772172,
0.018679105,
-0.011808928,
0.0010961498,
-0.004604963,
0.0037332284,
-0.022490108,
-0.0016770363,
0.0038725764,
0.0076090456,
0.027869588,
-0.008406245,
-0.0114719,
0.0034286075,
-0.0065266686,
0.022036418,
-0.013468141,
-0.007939592,
-0.009670099,
0.0046114447,
-0.029451026,
0.006141031,
0.014595887,
-0.009864538,
0.0136625795,
0.0032001417,
-0.0012290165,
0.012845935,
-0.002075636,
0.018277265,
-0.000334192,
-0.011633933,
-0.00653315,
0.020558681,
0.00034209108,
-0.00623501,
-0.000538758,
0.011037653,
0.023669705,
-0.026327038,
-0.000553746,
0.016190287,
-0.003811004,
0.0036522122,
-0.004135069,
0.0110570965,
0.009261777,
-0.052446675,
-0.013947756,
0.031110238,
-0.0022781768,
0.008211806,
0.017279144,
-0.012742234,
-0.012437614,
-0.008296063,
0.009184001,
0.0011439493,
0.026002973,
-0.0026994613,
-0.04101366,
-0.009164558,
0.04583575,
-0.042465474,
0.02882882,
0.010908027,
-0.019910552,
-0.0075442325,
-0.006896103,
-0.014634774,
0.023928957,
0.010084902,
0.015956959,
0.009994164,
0.017875424,
-0.011381162,
0.0034026823,
-0.0043068235,
0.008892342,
0.02389007,
-0.0033281473,
-0.013934794,
-0.0018180045,
-0.012152436,
-0.00040467613,
-0.002927927,
0.01252187,
-0.033832382,
0.04549872,
0.014388485,
0.017629135,
0.0009033311,
0.00027748063,
-0.026158525,
-0.03077321,
-0.013189444,
0.0025212255,
-0.030799136,
-0.008911787,
-0.0012970701,
0.0040022023,
-0.019405011,
0.005505864,
-0.0041869194,
0.004160994,
0.0133255515,
-0.014919952,
-0.0146866245,
0.020584607,
-0.021608653,
0.0016057419,
-0.010681181,
0.024693752,
-0.00079922524,
-0.025627058,
0.021284588,
0.0008798364,
0.028906595,
0.0040572933,
0.0067794393,
-0.013947756,
0.014790325,
-0.0075377515,
-0.025523357,
-0.009482142,
-0.014894026,
-0.01681249,
-0.0052628154,
-0.011763559,
0.0038725764,
-0.0042322883,
-0.0036230464,
-0.026404815,
-0.011646895,
0.013059818,
-0.03308055,
0.023527117,
-0.01860133,
0.037073035,
0.0024256264,
0.018121714,
-0.012839454,
0.010143233,
0.028491793,
-0.029399175,
0.006578519,
-0.027065907,
0.005975758,
0.007920148,
-0.04254325,
-0.00024507413,
0.030358408,
0.005522067,
0.0262363,
-0.013455178,
-0.0004484249,
0.014608849,
-0.005820207,
0.004702183,
-0.0363212,
-0.00668222,
-0.014595887,
0.00055901206,
0.017421734,
-0.0026800174,
-0.00025499862,
-0.000977866,
-0.011536713,
0.02378637,
-0.0007789712,
0.0011966099,
-0.009021969,
-0.011413569,
-0.0037429505,
0.01341629,
-0.0011431392,
0.018251339,
-0.0076738587,
-0.007641452,
0.006260935,
0.018393928,
0.017382845,
-0.028362166,
-0.0062155663,
-0.0025212255,
0.0048091244,
0.00031616588,
-0.013688505,
0.0019686946,
0.0058915014,
0.009903425,
-0.014790325,
0.03437681,
-0.014894026,
0.018692067,
0.0043165456,
0.002409423,
0.0087821605,
-0.0061572343,
-0.018264301,
0.0261326,
-0.010318229,
-0.0037429505,
0.017019892,
-0.025497433,
-0.0021307273,
-0.012087624,
-0.001401581,
-0.0068896213,
-0.0035031424,
-0.0005691391,
0.013241295,
0.012502426,
0.009203445,
-0.0032552327,
-0.002449931,
-0.014349597,
-0.03157689,
0.003645731,
-0.0011666339,
0.0010961498,
-0.002114524,
-0.009034932,
-0.019625375,
-0.040884037,
0.0294251,
0.02129755,
-0.01910687,
0.011523751,
0.010130271,
0.027895512,
0.0018163841,
0.0043327487,
0.015684744,
-0.0149069885,
-0.020416094,
0.015931034,
0.028699193,
-0.0076868213,
0.007071098,
-0.017292107,
-0.017292107,
-0.012068179,
0.018860582,
0.00017367858,
-0.006973878,
-0.007213686,
-0.018186526,
-0.015295867,
-0.008114587,
0.029269548,
-0.0032276872,
0.022671586,
0.024045622,
0.0059465924,
-0.003102922,
-0.011679302,
-0.024304872,
0.04205067,
-0.0029149645,
0.002723766,
-0.025964085,
-0.013403327,
-0.025069667,
-0.03017693,
-0.012256137,
-0.0038758172,
0.0035647147,
0.015542156,
-0.0034026823,
-0.010752476,
0.019625375,
0.024564125,
0.011595045,
0.0028890392,
-0.022269744,
0.011834852,
-0.012139474,
0.032043546,
0.027636262,
-0.017538397,
0.0065169465,
-0.014310709,
0.014673662,
-0.010091383,
-0.008445133,
0.043372855,
-0.0023818775,
0.011180242,
-0.006588241,
0.008386802,
0.0059077046,
-0.009002525,
0.02035128,
0.0030154246,
-0.0030105636,
0.0015077123,
-0.013481103,
-0.029269548,
0.0066109253,
0.038161892,
0.03136949,
0.024745602,
0.01186726,
0.0069479533,
0.020675346,
-0.0061377906,
0.0030494514,
-0.006014646,
0.026417777,
0.0041156253,
0.015879184,
0.00052498525,
-0.029139923,
-0.0034999016,
0.016332874,
-0.00867846,
0.014842176,
0.027091831,
0.023760444,
0.009786762,
0.0062317695,
0.022399371,
0.013079262,
0.019638337,
0.0020821174,
0.005431329,
-0.025380768,
0.029347325,
-0.033573132,
-0.008970118,
-0.01616436,
0.012482983,
-0.009968239,
0.0001807675,
-0.018095788,
-0.010065458,
0.003057553,
0.0006290911,
-0.029865827,
0.018173564,
-0.0040119244,
-0.0060340897,
-0.015619932,
-0.008354395,
-0.0145699615,
-0.028336242,
-0.0033103237,
0.020338317,
-0.0019881385,
-0.022088269,
0.0021080426,
0.006043812,
0.03849892,
0.02344934,
-0.004828568,
0.005829929,
0.0038369293,
0.016345838,
-0.035102718,
-0.005356794,
-0.024278948,
-0.011575601,
0.016125472,
0.020014253,
-0.009112707,
-0.0073951627,
-0.0037688757,
0.022775287,
0.008198844,
-0.010195084,
-0.008704385,
-0.016799528,
0.0033540726,
0.016319912,
0.0048966217,
-0.018886507,
-0.02159569,
-0.022023456,
-0.02429191,
-0.02219197,
0.00048650254,
-0.00423877,
-0.019067982,
0.0044332086,
0.013157038,
-0.0061118654,
-0.018873544,
0.029891754,
-0.03168059,
0.0015603729,
-0.008017368,
0.005596602,
0.022036418,
0.01167282,
0.0070905415,
0.009073819,
-0.030254707,
0.011232092,
-0.028439943,
0.040884037,
0.03131764,
-0.029762127,
0.009300665,
-0.0055641956,
0.0040670154,
-0.0100330515,
-0.0049257874,
-0.01705878,
0.023008613,
-0.011841334,
-0.009423809,
-0.007006285,
-0.0061604753,
0.020117953,
0.019586487,
-0.0025196052,
-0.0142329335,
-0.015282904,
0.0023915996,
0.0026152043,
-0.020753121,
0.03266575,
-0.035180494,
-0.005116986,
0.032795377,
0.022801211,
0.0005266056,
-0.0153606795,
-0.00067000435,
0.004828568,
-0.006098903,
-0.020675346,
-0.03935445,
0.013610729,
-0.029554725,
0.045265395,
0.027402934,
0.018717993,
0.008270138,
0.039198898,
0.017279144,
0.014608849,
0.0019913793,
-0.0045693163,
0.026702954,
-0.0063225077,
0.018834656,
-0.0066757384,
0.0025941401,
0.0016470603,
-0.015036615,
0.019560562,
0.028517717,
-0.0066044442,
-0.022179008,
0.0060178866,
-0.009352515,
-0.037980415,
0.004873937,
-0.003461014,
0.014103307,
-0.031706516,
-0.010156197,
0.0060729776,
0.012943155,
-0.0018423094,
0.004802643,
0.035621222,
-0.01341629,
0.017642098,
-0.021556802,
0.020260543,
0.0022619735,
0.01895132,
-0.007135911,
-0.006503984,
0.012055217,
0.0057975226,
-0.01845874,
0.019755,
-0.016125472,
0.02334564,
0.021530876,
-0.020571645,
-0.027843663,
-0.008114587,
-0.022412334,
-0.0051947613,
-0.012826492,
-0.0020821174,
-0.0117376335,
-0.013973681,
0.009300665,
-0.010882102,
0.017590247,
-0.0044170055,
-0.033936083,
0.042724725,
-0.012055217,
0.011044134,
-0.030488033,
0.018419852,
0.025562245,
-0.008607166,
-0.037824865,
-0.015982885,
-0.004125347,
-0.013792206,
0.030280631,
0.038913723,
-0.016423613,
-0.013247776,
0.008652534,
0.0139996065,
0.0052628154,
-0.008399764,
0.012340394,
0.00085553154,
-0.003655453,
0.009443253,
-0.0060373303,
-0.020467944,
-0.015049578,
0.007427569,
0.014894026,
0.008898824,
-0.0031952807,
-0.018225415,
0.02434376,
-0.005570677,
-0.016734716,
0.016319912,
-0.014168121,
-0.016488425,
-0.03963963,
-0.0035031424,
0.0007465647,
-0.022088269,
0.031628743,
0.0021728557,
0.009618249,
0.022684548,
-0.0028047822,
-0.014090345,
-0.0142329335,
-0.0026670548,
0.038032264,
0.002224706,
0.0049808784,
0.005178558,
0.010687663,
0.011996886,
-0.021064224,
-0.0037267471,
0.00020628762,
-0.031447265,
-0.01770691,
0.028232541,
-0.00024426397,
-0.0007502104,
0.0109404335,
-0.030980611,
-0.008769198,
-0.026119636,
-0.02872512,
-0.0008798364,
-0.024460424,
-0.002304102,
0.0245382,
0.009637692,
0.025562245,
-0.017214332,
-0.007907186,
-0.023514155,
0.025523357,
0.003127227,
0.027273308,
0.006824808,
0.02348823,
-0.022516035,
-0.009845094,
-0.009346033,
-0.047883842,
-0.005424848,
-0.015503269,
-0.02448635,
0.0019719354,
-0.006759995,
0.017292107,
0.0091256695,
-0.012379282,
0.0057489127,
0.011044134,
0.012670941,
0.0018520313,
-0.010551555,
0.024667826,
-0.022827137,
-0.030721359,
-0.0008275809,
-0.008458096,
0.0005444292,
0.006818327,
-0.016021773,
0.0049063438,
-0.04345063,
-0.004183679,
-0.007933111,
0.024227098,
-0.036295276,
0.015088465,
-0.011458937,
-0.01012379,
-0.0006610925,
-0.00095356116,
0.001785598,
-0.02194568,
-0.008114587,
0.005207724,
-0.003506383,
0.0068766586,
-0.0014955598,
0.036373053,
-0.00071618357,
-0.020519795,
-0.023319716,
0.013740355,
-0.025964085,
0.03875817,
0.012606127,
0.018484667,
-0.007291462,
0.0064002834,
-0.06927213,
-0.032484274,
0.019119833,
0.009281221,
0.00029854485,
-0.006967397,
-0.0015490305,
-0.013960719,
0.009132151,
0.012288543,
-0.011711708,
-0.017564321,
0.0003082668,
0.012722791,
0.020273505,
-0.003276297,
-0.018575404,
-0.012495945,
0.018108752,
-0.004754033,
0.0052142055,
0.009670099,
-0.026093712,
0.0081081055,
-0.017434696,
0.011083022,
0.0007267157,
-0.006627129,
0.018316152,
-0.007822928,
0.010117308,
0.0078812605,
-0.010551555,
0.004844771,
-0.022062343,
0.00012679042,
-0.0033799976,
0.0003113049,
-0.0041156253,
-0.026884431,
0.030669509,
-0.03665823,
0.03486939,
0.011899666,
-0.015049578,
0.03805819,
0.01800505,
-0.025964085,
-0.020856822,
-0.004485059,
-0.0018860581,
-0.0063322294,
-0.024136359,
-0.00962473,
-0.0045952415,
-0.022853062,
0.007524789,
-0.04474689,
0.0010426791,
-0.011361718,
0.00059263385,
-0.024382649,
0.024071546,
-0.023177126,
-0.020040179,
-0.0073238686,
-0.014349597,
-0.02194568,
-0.023319716,
0.00523689,
0.00050513627,
-0.0027302473,
-0.00009929553,
-0.0018487907,
-0.00078302197,
-0.019586487,
-0.017616171,
0.0015668542,
-0.0010880481,
0.020934597,
0.19869071,
-0.01182189,
0.0039179455,
0.009404366,
-0.008121069,
-0.017330995,
0.010396005,
0.002274936,
-0.0051299487,
0.0043878397,
0.018523553,
0.023669705,
0.0017418492,
0.0015295867,
0.022878988,
-0.035336044,
-0.004948472,
0.001491509,
-0.011731152,
-0.040572934,
-0.004193401,
-0.01571067,
-0.0067859204,
-0.0020335077,
0.02807699,
-0.015918072,
-0.027273308,
0.011543195,
0.010933952,
0.0034934203,
-0.029347325,
0.009864538,
-0.02364378,
0.0051947613,
0.014297747,
0.00050594646,
-0.0067016636,
-0.0138959065,
0.012314469,
-0.0013076022,
-0.001630857,
-0.0030235262,
-0.0010208046,
0.023319716,
0.022075307,
0.017784685,
-0.0132088885,
-0.003930908,
-0.005875298,
-0.002334888,
-0.03691748,
-0.012683903,
0.0043781176,
0.0018147639,
-0.00069066347,
-0.010285823,
0.008393283,
0.013338515,
-0.030669509,
0.0108302515,
-0.024175247,
0.014466261,
-0.026210375,
0.017032854,
-0.013338515,
0.020727195,
0.0038401699,
-0.0074405316,
0.013273701,
-0.015827334,
-0.0015255358,
0.0022781768,
-0.018679105,
-0.030565808,
-0.001600881,
-0.02303454,
0.020104991,
0.0045952415,
0.009715468,
0.01865318,
0.00997472,
-0.014038495,
-0.022606773,
-0.013163519,
0.0071164668,
-0.030799136,
0.03372868,
0.013228333,
-0.0425951,
-0.019430935,
0.002628167,
0.0011787864,
0.0018374484,
-0.008244213,
0.007310906,
-0.013934794,
0.0036911,
0.023578968,
0.018471703,
-0.0035841586,
-0.03665823,
0.072486855,
0.030021379,
-0.0056290086,
-0.0057780785,
0.028958445,
-0.015529194,
0.0048706965,
-0.016229173,
-0.004796162,
0.013623691,
-0.014855138,
-0.0042128447,
0.00094221893,
0.014932914,
0.027688112,
0.008321988,
-0.015542156,
0.036295276,
-0.0007044362,
-0.0011625831,
-0.026067786,
0.017888386,
0.035880473,
-0.013947756,
0.0034901798,
-0.028751044,
0.015088465,
-0.003076997,
-0.040313683,
-0.012353357,
0.003655453,
0.0016178944,
0.026171487,
0.015231053,
0.0016802769,
0.012385763,
-0.021077186,
-0.029658426,
0.00032649547,
-0.022904912,
-0.0068896213,
0.030721359,
0.012113549,
0.009449734,
-0.006014646,
0.010253415,
0.015192166,
-0.04179142,
-0.036684155,
-0.0030932003,
-0.008211806,
-0.016981004,
0.00060600153,
0.015399568,
-0.025821498,
-0.015529194,
-0.016475463,
-0.0065201875,
0.017097669,
-0.02418821,
0.022554923,
0.0072590555,
-0.008613647,
-0.0034545327,
-0.010927471,
-0.16135843,
0.0029700554,
0.015269942,
-0.017227294,
0.025549283,
0.0121913245,
-0.0139996065,
-0.008095143,
-0.013312589,
0.019534636,
0.05073561,
0.0077127465,
-0.056724332,
-0.018523553,
0.013040375,
0.0059465924,
-0.0030494514,
0.027195532,
0.016436575,
0.0058137258,
0.039872956,
-0.028517717,
-0.000041242332,
-0.008237732,
0.0011990404,
0.009780281,
0.019288348,
0.0014194046,
-0.017823573,
-0.024797453,
-0.010765438,
-0.001625996,
0.013033893,
-0.00012486629,
0.019884627,
0.010642294,
0.0138959065,
-0.009994164,
-0.0014169741,
0.015632894,
0.023527117,
0.0037040627,
-0.005032729,
-0.0029716757,
-0.009546954,
0.03406571,
-0.025717797,
-0.025354844,
0.02802514,
-0.014868101,
0.0162551,
-0.008885861,
0.00443969,
0.027221458,
0.013727392,
0.008237732,
0.01151727,
0.031239863,
0.009333071,
0.0062576947,
0.00056387304,
-0.010784882,
0.023501191,
-0.004079978,
0.0047605145,
-0.03186207,
-0.004971157,
0.025808534,
-0.016605088,
0.0070192474,
-0.022904912,
-0.028258465,
0.01980685,
-0.020416094,
0.022762325,
0.01406442,
-0.0025827978,
-0.0087821605,
-0.002872836,
0.0139996065,
0.0037235066,
0.0030786172,
-0.018562442,
-0.010791363,
-0.008283101,
-0.0021712354,
0.011484862,
-0.0012735754,
-0.0021663744,
-0.009436772,
0.0066692573,
-0.029710276,
-0.0057067843,
-0.0011650135,
0.019184647,
0.022878988,
-0.024965966,
-0.013202407,
-0.02005314,
0.006205844,
0.013494066,
-0.004977638,
-0.03525827,
0.01845874,
0.025601134,
-0.020558681,
-0.019884627,
-0.002618445,
0.049568977,
-0.041713644,
0.009961757,
-0.0023834978,
0.028984372,
0.026002973,
-0.014894026,
0.023864144,
0.017136555,
-0.005003563,
-0.011718189,
-0.023073426,
0.063309334,
0.004342471,
-0.024175247,
0.034350887,
0.00473783,
-0.010065458,
-0.12682606,
-0.0056128055,
0.0002637079,
0.00017469127,
-0.015788445,
0.017719872,
-0.011497825,
0.01676064,
-0.0067211078,
0.011530232,
-0.017499508,
-0.028621418,
-0.0040054433,
-0.02019573,
0.003535549,
-0.0015052818,
0.0091256695,
0.0016932394,
-0.023799332,
0.031836145,
0.0075701578,
-0.0072007235,
-0.0023608133,
-0.005567436,
0.022438258,
0.02329379,
-0.03953593,
0.014894026,
0.016682865,
0.036943406,
0.0065558343,
-0.009708987,
0.03963963,
-0.0013270461,
-0.002109663,
-0.00074453925,
0.0020578126,
-0.024265986,
0.036684155,
-0.008691423,
0.0005067566,
0.012042254,
0.0058882604,
-0.01571067,
0.008931231,
-0.0016689346,
-0.017019892,
-0.008749754,
0.014051457,
-0.024784489,
-0.022684548,
-0.013105188,
-0.015905108,
-0.018368002,
0.0030202856,
-0.021984568,
-0.012832973,
0.028621418,
-0.0043327487,
-0.02040313,
0.008257176,
-0.007803485,
-0.020610532,
-0.007246093,
0.031732444,
-0.037773013,
-0.016319912,
-0.01217188,
0.023203053,
-0.04682091,
-0.01256724,
-0.0025746962,
-0.017823573,
0.0013659339,
-0.0030964408,
-0.004967916,
-0.019029096,
-0.0011925591,
-0.013623691,
-0.027091831,
-0.01351999,
-0.019482786,
0.006319267,
-0.013973681,
0.031162089,
0.0089766,
0.01725322,
-0.005479939,
0.013390365,
-0.009806206,
-0.005291981,
0.036580455,
-0.010752476,
-0.037773013,
0.0060243676,
0.015438455,
0.032795377,
0.02344934,
0.017680986,
0.024032658,
-0.00047799584,
-0.012353357,
-0.058124293,
0.030591734,
-0.01082377,
0.00179532,
0.012606127,
-0.029891754,
-0.0020967005,
-0.029891754,
0.0049193064,
0.039017424,
-0.019119833,
-0.008289582,
-0.022062343,
0.011776521,
-0.029062146,
-0.008373839,
0.016695827,
-0.0037883196,
0.02807699,
0.021816054,
0.0009381681,
0.0024175248,
0.010039533,
0.00867846,
-0.023475267,
0.0006080269,
-0.014738475,
0.025380768,
0.0008741653,
-0.008146994,
-0.0050456915,
-0.046017226,
-0.014284784,
0.0026589532,
-0.0071488735,
-0.029839903,
-0.0133255515,
0.00887938,
0.036580455,
0.033184253,
-0.011802446,
-0.023656743,
-0.0018293468,
-0.013610729,
-0.013857018,
-0.0021582728,
-0.022360483,
0.010525631,
0.006708145,
-0.026002973,
0.05231705,
0.013740355,
-0.005282259,
-0.041817345,
-0.015956959,
-0.0056095645,
0.0021112834,
-0.0067729577,
-0.011478381,
-0.037176732,
0.014349597,
0.033884235,
0.0038725764,
0.022127157,
0.0020383687,
-0.02064942,
-0.013273701,
0.018316152,
0.021634577,
-0.007771078,
-0.030410256,
-0.0007777559,
0.0059530735,
-0.011834852,
-0.0009033311,
-0.005366516,
-0.013882943,
0.02313824,
-0.018082825,
0.015969923,
-0.020830896,
-0.009034932,
0.011679302,
0.013831093,
0.034532364,
0.006079459,
-0.007103504,
0.023384528,
-0.010609888,
0.007524789,
-0.006503984,
0.016190287,
0.022153081,
-0.0065428717,
0.024395611,
0.016877305,
0.0073822,
0.008769198,
-0.0017629134,
0.0456802,
0.00688314,
-0.005408644,
0.012184843,
-0.021829017,
-0.007634971,
0.027402934,
-0.02653444,
-0.023125276,
-0.026910355,
0.00057481026,
-0.0048350496,
0.024253022,
0.0033378692,
-0.0033637944,
-0.025912235,
0.00032467258,
-0.011873741,
-0.021738278,
-0.011802446,
0.033573132,
0.018912433,
0.023125276,
-0.016229173,
-0.004643851,
0.011666339,
0.014492186,
0.024628937,
-0.008056255,
0.032043546,
-0.00021469305,
0.018368002,
-0.010396005,
-0.02140125,
-0.0046794983,
-0.009521029,
-0.025730759,
0.016942117,
0.02094756,
-0.007978479,
0.06724996,
0.004533669,
-0.025925199,
-0.006714626,
-0.029321399,
0.024512274,
0.039717402,
0.008749754,
-0.0050489325,
-0.0068442523,
0.03406571,
-0.01735692,
0.02050683,
-0.022606773,
-0.037669312,
0.024771526,
-0.0033313879,
0.014155158,
0.0023462304,
-0.0020480906,
0.025601134,
0.0063808393,
0.017719872,
0.027014056,
-0.027091831,
-0.0007137531,
0.028595494,
-0.018018013,
-0.0027918199,
-0.013701467,
0.016021773,
0.016877305,
-0.034039784,
0.0013554017,
0.0045012627,
0.023553042,
-0.029839903,
-0.0262363,
0.00947566,
0.023553042,
-0.009585842,
0.011413569,
-0.014673662,
-0.012508908,
-0.0037915602,
-0.013377402,
-0.028932521,
-0.012865379,
-0.009047894
] |
For individuals genetically predisposed to breast and ovarian cancer through inheritance of a mutant BRCA allele, somatic loss of heterozygosity affecting the wild-type allele is considered obligatory for cancer initiation and/or progression. However, several lines of evidence suggest that phenotypic effects may result from BRCA haploinsufficiency. Archival fixed and embedded tissue specimens from women with germ line deleterious mutations in BRCA1 or BRCA2 were identified. After pathologic review, focal areas of normal breast epithelium, atypical ductal hyperplasia, ductal carcinoma-in-situ, and invasive ductal carcinoma were identified | [
-0.038347475,
-0.014280301,
0.0021333783,
-0.030213969,
-0.023400493,
0.024613852,
-0.0055967844,
0.007073482,
-0.022893814,
-0.006113462,
0.0007120983,
0.004246756,
0.014693643,
0.018787062,
-0.016920356,
0.0049634376,
0.055841174,
-0.010720226,
0.02741391,
-0.0065034702,
-0.045494292,
0.013566952,
-0.00024958857,
-0.014400303,
-0.0044234265,
0.0014350303,
0.01756037,
-0.040507518,
-0.0009683537,
-0.010740226,
0.018120382,
0.021907128,
-0.0059667923,
-0.003933416,
-0.0050601065,
0.017347032,
0.013446949,
-0.008986856,
0.0140669625,
-0.012226924,
-0.010826894,
0.014880314,
-0.010920229,
-0.002106711,
-0.017507035,
0.0060867947,
0.025547205,
-0.0045167617,
-0.0016558681,
-0.012306926,
0.007560159,
0.006546804,
-0.020680435,
0.006793476,
-0.014840312,
-0.001634201,
0.010740226,
0.022520473,
0.0073401546,
0.0041767545,
-0.009486866,
0.0034834067,
-0.026760563,
0.012053587,
-0.022093799,
0.006236798,
0.0040100846,
0.0047200993,
-0.011600244,
0.01409363,
0.03501407,
0.026200552,
-0.024387179,
0.0018700394,
0.007013481,
-0.024733854,
-0.017573703,
0.0013016941,
-0.0054067806,
0.0050434396,
0.026427222,
-0.015520327,
0.0121935895,
0.010826894,
0.02246714,
0.019267073,
-0.016187007,
0.011393573,
0.019947086,
0.004966771,
0.015573661,
0.0034117384,
-0.0013075275,
0.003460073,
-0.0023117154,
0.021813793,
-0.00743349,
0.017920377,
0.017067026,
-0.0147203095,
-0.011820248,
0.008766851,
-0.0055834507,
-0.013720289,
-0.038214136,
-0.010973564,
0.0005658452,
-0.0032550686,
0.011613578,
-0.020640435,
-0.02298715,
0.024320511,
-0.010720226,
-0.02741391,
0.039680835,
-0.021893794,
0.00874685,
0.0020433764,
-0.016987024,
0.009280195,
0.015560327,
0.0014000294,
0.013460283,
0.0017050359,
0.022693811,
-0.0041434206,
-0.02173379,
0.020347094,
0.0060767946,
-0.009566868,
0.01800038,
0.015827,
0.013233611,
0.009453532,
-0.0022033798,
0.0033684042,
-0.009660203,
-0.025360534,
-0.023227155,
-0.03656077,
0.005536783,
0.03520074,
-0.01649368,
-0.009366863,
-0.016933689,
0.019360408,
-0.000105783474,
0.004146754,
-0.0022133798,
-0.0018633725,
0.0028600602,
-0.004016751,
0.010713559,
-0.023747167,
0.022893814,
0.008553513,
0.0133069465,
0.021200446,
-0.023587164,
-0.028720604,
0.006906812,
-0.0011725246,
-0.0032484017,
0.019253738,
0.017067026,
0.026613893,
0.01985375,
0.004476761,
0.004330091,
-0.019027067,
0.0053667794,
0.016720353,
-0.030800648,
0.012520264,
-0.023653831,
0.004056752,
-0.016653683,
0.023587164,
-0.025760543,
-0.023307158,
-0.036027424,
0.035040736,
0.030933984,
-0.002168379,
-0.009553534,
0.005270111,
0.018840397,
-0.023027152,
-0.007493491,
-0.025440535,
-0.017773706,
0.018547056,
0.017507035,
0.00004599055,
-0.6430002,
-0.007533492,
-0.0079135,
-0.02140045,
0.0048034345,
0.02586721,
0.02121378,
-0.0059501254,
-0.017360365,
0.0073401546,
-0.019440409,
0.03346737,
0.0003160483,
-0.011200235,
-0.00036584103,
-0.06309466,
0.0020683769,
-0.017827041,
0.03154733,
-0.005353446,
-0.004756767,
0.010926897,
-0.014026962,
0.019160403,
0.0049101035,
0.029520622,
0.012226924,
-0.019987088,
0.015840333,
0.02390717,
-0.012440261,
0.024013838,
-0.026107216,
0.0036934111,
0.05445448,
0.003141733,
0.026653893,
0.023973837,
0.03125399,
0.027387243,
0.00918686,
0.0127069345,
0.032134008,
0.006020127,
-0.009733538,
0.009806873,
0.0007241819,
0.014853646,
0.00396675,
-0.005260111,
-0.0040134178,
0.018787062,
-0.031387325,
-0.014946981,
0.010593556,
0.00007515783,
0.037654124,
-0.027920587,
0.007426823,
0.00021667122,
0.001983375,
0.042587563,
-0.0190404,
-0.040827524,
-0.0027317242,
0.015760332,
-0.003358404,
0.011826916,
-0.019440409,
-0.00039542498,
0.019800417,
0.0396275,
-0.015533661,
-0.0037434122,
0.022680476,
0.039600834,
-0.017520368,
0.0031600664,
-0.009660203,
0.027867254,
0.007853499,
-0.00036979944,
-0.032454018,
0.028533934,
0.021227114,
-0.01682702,
-0.023507161,
0.014586974,
-0.01188025,
-0.008673516,
0.031520665,
0.002246714,
-0.00079084997,
-0.02158712,
-0.015613662,
0.008300175,
-0.013286946,
0.012773602,
-0.02136045,
-0.02678723,
-0.025947213,
-0.010086879,
-0.002503386,
0.014453637,
0.026547225,
-0.005000105,
-0.0035800752,
0.0048967698,
0.038027465,
-0.020840438,
-0.007906833,
0.0010916897,
0.01286027,
-0.0065001366,
-0.011520242,
-0.01718703,
0.008653515,
-0.00539678,
-0.00076084933,
-0.015293655,
0.027973922,
0.008300175,
0.0093335295,
-0.03578742,
0.025120528,
-0.00018208717,
-0.0048134346,
-0.0065734717,
0.0084868455,
-0.020987108,
0.012620266,
-0.02760058,
-0.0040334184,
-0.025040528,
0.005670119,
-0.021813793,
0.020160424,
-0.0069934805,
0.032080676,
-0.020227091,
-0.018720394,
-0.019573744,
0.011833582,
0.0025900544,
-0.014226966,
-0.00065876386,
-0.028160593,
-0.008446844,
0.018120382,
-0.0034834067,
0.0038200803,
-0.013893626,
-0.008100171,
0.020747103,
0.0025350533,
-0.0061201286,
0.0030667312,
-0.00902019,
-0.003156733,
-0.0062334645,
0.012900271,
-0.0092268605,
0.015146986,
-0.025480537,
-0.0041700876,
-0.012540264,
0.0040667523,
0.0017833709,
-0.0059201247,
-0.032000672,
-0.008780185,
-0.014053629,
-0.030267304,
-0.005470115,
0.0036400766,
0.014920314,
-0.011906917,
-0.0016700352,
0.0005566784,
-0.0066468064,
0.018360386,
-0.047974344,
-0.023040485,
0.010253549,
0.03480073,
0.00920686,
0.030480642,
-0.005403447,
0.011340238,
0.024347179,
-0.0069601466,
0.022413805,
-0.0003900082,
0.009160193,
0.008360176,
-0.025120528,
0.004140087,
0.023000484,
0.0049201036,
0.03589409,
0.029840628,
-0.006946813,
0.016000336,
-0.01394696,
0.024347179,
-0.022293802,
0.014506971,
0.012880271,
0.0076468275,
-0.0070334813,
0.0004712599,
0.027840586,
-0.012246924,
0.0052001094,
-0.015306989,
0.0005308445,
0.012853604,
-0.0017533703,
0.0044300933,
-0.008653515,
-0.018587058,
0.007946834,
0.019840417,
0.0028700605,
-0.0021517118,
0.0051934426,
0.013746956,
-0.0046634316,
0.020160424,
0.0067401417,
0.0021267114,
0.028480599,
-0.001855039,
0.019373741,
0.010266882,
0.016867021,
0.0011983586,
0.0006487637,
0.03365404,
-0.0034834067,
-0.0108002275,
0.003083398,
0.0020833772,
0.018680394,
0.003403405,
-0.006546804,
0.037494123,
0.005263444,
-0.008140171,
-0.0036367432,
0.026320554,
-0.005486782,
-0.0077601634,
0.009733538,
0.016187007,
-0.015840333,
0.026400555,
0.024427181,
0.051681086,
0.009893541,
0.021227114,
-0.022333803,
0.008293508,
-0.010266882,
-0.01286027,
0.01027355,
0.01822705,
0.020480432,
0.0012275259,
-0.0026917234,
-0.024267178,
-0.0237605,
0.0022317136,
-0.029493954,
0.009300196,
0.015186986,
0.009713538,
0.026627228,
0.009193527,
-0.0010200215,
-0.024667185,
-0.037574124,
0.026173884,
0.045254286,
-0.0026967234,
-0.0058367895,
-0.003135066,
-0.006633473,
0.01818705,
0.0068268105,
0.039574165,
0.0106935585,
-0.0022433805,
0.0038600813,
0.0066534732,
0.015533661,
0.0009208527,
-0.008053503,
0.022573808,
-0.014240299,
0.001698369,
-0.018907065,
-0.0024667187,
0.011626911,
0.02240047,
0.017987045,
-0.0070268144,
-0.012473596,
-0.012693601,
-0.023333825,
0.0016300343,
-0.021600455,
-0.015360323,
-0.009546868,
-0.0045167617,
0.0055734506,
0.0082735075,
0.013786957,
-0.0039267493,
-0.0075401585,
-0.0016783687,
-0.013100276,
0.00037709126,
-0.00983354,
0.024893858,
0.030480642,
-0.025253864,
0.022693811,
0.01649368,
0.016947024,
-0.009273528,
-0.012313592,
0.016040338,
-0.020187091,
-0.0012291925,
0.009900209,
0.018733727,
0.016773686,
-0.0017042025,
0.020253759,
0.01626701,
-0.0365341,
0.014226966,
-0.008900187,
-0.029600622,
-0.028987277,
0.021987129,
0.03242735,
0.01933374,
-0.0089268545,
0.0075468253,
0.019107068,
0.011300238,
0.008033502,
-0.019080402,
0.011333572,
0.007220152,
0.019467076,
0.03272069,
-0.024400514,
0.006130129,
-0.00900019,
-0.011580244,
-0.0089268545,
0.021480452,
-0.010853562,
0.011606911,
0.016200341,
0.008886853,
0.001990042,
0.00080460025,
0.0048967698,
-0.007153484,
-0.019080402,
0.0070268144,
-0.0008308508,
-0.028640602,
-0.042000882,
0.016107006,
-0.0098802075,
-0.0010041877,
-0.0043167574,
0.0041900882,
-0.005560117,
-0.0141202975,
-0.0093868645,
0.006750142,
0.0010675224,
0.008853519,
-0.014346968,
-0.027093904,
-0.001444197,
-0.028453931,
-0.018907065,
-0.00025813043,
-0.015306989,
-0.014466971,
-0.020907106,
0.03501407,
0.019053735,
0.007213485,
-0.009393531,
-0.0015942003,
0.032400683,
-0.006793476,
-0.010193548,
-0.012700267,
-0.040480852,
0.024973858,
0.005633452,
-0.025333866,
-0.03501407,
-0.043414246,
0.023773834,
0.0046834317,
-0.022533808,
0.01332028,
0.0024350511,
-0.0015575328,
0.025147196,
0.008480178,
0.01252693,
-0.0036134094,
-0.010140213,
0.01346695,
-0.017200362,
-0.032507353,
-0.031680666,
-0.0062567983,
-0.012173589,
-0.034320723,
-0.005743454,
0.006273465,
-0.01236026,
-0.0051967762,
-0.021267114,
0.0052901115,
-0.007393489,
-0.00076251605,
0.024787188,
0.0077468297,
0.02424051,
0.0023367158,
0.018013712,
0.02240047,
0.00082043395,
0.03050731,
-0.013333614,
-0.026187217,
0.0021333783,
-0.015293655,
-0.02818726,
-0.01712036,
-0.0013625287,
0.00007583493,
0.03512074,
0.003358404,
-0.032694023,
-0.025080528,
-0.009826873,
-0.008100171,
-0.008200172,
-0.0043500913,
-0.0060867947,
-0.009633536,
0.009466866,
0.017400365,
-0.033867378,
0.0057234536,
-0.031814,
0.0012025253,
0.016960356,
-0.009366863,
-0.0013791957,
-0.012166923,
-0.001470031,
-0.012440261,
-0.021427117,
-0.008800185,
-0.028827272,
0.011913584,
-0.008526846,
0.042480893,
0.0427209,
0.009633536,
0.00619013,
0.039014153,
0.035574082,
0.014920314,
0.00397675,
-0.007206818,
-0.0019867085,
-0.020747103,
0.019413741,
0.0054434477,
0.011280238,
0.024347179,
-0.0034734064,
0.040747523,
0.022587141,
-0.019027067,
-0.018893732,
-0.0028000588,
-0.04933437,
-0.038587477,
0.013440283,
-0.004096753,
0.028453931,
-0.037200782,
0.01708036,
0.015360323,
0.00697348,
-0.0028650602,
-0.020680435,
0.017053692,
-0.0017133694,
0.010333551,
-0.0048534353,
-0.0035500748,
-0.013653621,
-0.025840543,
0.012873604,
-0.002420051,
-0.0027983922,
-0.0028417264,
0.015440325,
-0.0011341905,
-0.028933942,
-0.0010475221,
0.0048301015,
-0.017053692,
-0.011660245,
-0.011653579,
-0.0079335,
-0.0221338,
-0.022160467,
-0.008833519,
0.0016042005,
-0.00981354,
0.026360555,
-0.021493785,
0.005740121,
0.019280406,
-0.018467056,
0.0023267157,
-0.012786936,
0.03309403,
-0.02904061,
0.03309403,
0.003576742,
-0.021307115,
-0.02044043,
0.0044334265,
0.0034050716,
0.023547161,
0.02468052,
0.009673537,
-0.0020817104,
0.00856018,
0.016587015,
-0.020680435,
-0.032854024,
-0.027280575,
0.013366948,
-0.007673495,
0.022093799,
0.0050434396,
0.0069801467,
-0.021307115,
0.01046022,
-0.018293718,
0.00872685,
0.00013219028,
-0.027760584,
-0.0063301334,
0.004893436,
-0.024813855,
0.0127602685,
0.0050801067,
-0.011660245,
-0.017320365,
-0.025373867,
-0.0029633958,
0.021947129,
-0.0019567078,
0.03856081,
0.0043034237,
0.0026133882,
-0.00008781435,
0.0051834425,
-0.008006835,
0.008593515,
-0.014893646,
0.042374223,
-0.00065043033,
-0.015920335,
-0.011193569,
0.00073001534,
0.011506909,
0.023773834,
0.0015958669,
-0.009600202,
-0.018693727,
-0.001508365,
0.01668035,
0.002268381,
-0.0097935395,
-0.00808017,
-0.013746956,
0.0110468995,
-0.023040485,
-0.047947675,
0.029253948,
-0.036507435,
-0.019200403,
-0.010206881,
0.01505365,
0.029413952,
0.023707166,
0.0017083692,
-0.003733412,
0.033627376,
-0.014373636,
0.013073608,
0.01282027,
-0.00037042447,
-0.026467223,
0.019533744,
-0.01564033,
-0.0030033966,
0.008786852,
-0.010140213,
-0.012273592,
-0.04792101,
-0.0007195985,
0.00285006,
0.012146922,
-0.007846831,
0.007086816,
-0.0071068164,
0.032640688,
0.001731703,
-0.02457385,
-0.0038300806,
-0.011520242,
0.013933627,
0.005236777,
-0.010866895,
-0.017387033,
-0.026280552,
0.00005104274,
-0.005806789,
0.0012075254,
0.007900166,
0.014546973,
-0.0057534543,
0.013600286,
0.0004745933,
-0.0008758518,
-0.006396801,
-0.02476052,
0.020493764,
-0.0040667523,
-0.019573744,
-0.0073401546,
-0.0032034006,
-0.00918686,
0.035760753,
-0.014520305,
0.003375071,
-0.008433511,
-0.021480452,
-0.03600076,
-0.002945062,
-0.018160382,
0.031333994,
0.02509386,
-0.0075401585,
-0.007586826,
-0.0043334244,
-0.043040905,
-0.022187134,
0.0021767125,
0.0022983816,
-0.0063801343,
0.039974175,
0.00015760749,
0.003710078,
-0.00983354,
0.01852039,
-0.0018950399,
-0.011200235,
0.0019700415,
-0.014080296,
0.020613767,
0.016213674,
-0.031654,
-0.010580223,
0.0190404,
0.002201713,
-0.019587079,
0.02246714,
-0.018840397,
0.023880502,
-0.0035634083,
0.0029033944,
0.016747018,
0.027053902,
0.021147111,
0.006773476,
-0.012133589,
-0.0023533828,
0.026547225,
-0.0029250616,
-0.0055967844,
-0.015827,
0.018773729,
0.011140235,
-0.028107258,
-0.012413595,
0.015146986,
-0.020333761,
0.005526783,
0.036320765,
-0.0033150697,
0.02545387,
0.0060667945,
0.0101468805,
-0.0054834485,
-0.018600391,
0.0028600602,
0.006400135,
-0.008840186,
-0.018280385,
-0.026907234,
-0.0026400555,
-0.0050667734,
-0.01852039,
-0.0002070877,
-0.009266862,
-0.019973753,
-0.03282736,
0.021707123,
-0.014880314,
-0.0073668216,
-0.0035600748,
0.015026983,
-0.020680435,
-0.0010875228,
-0.01202692,
0.015066984,
-0.011673579,
0.023493828,
0.009506866,
-0.024253843,
-0.014853646,
-0.00904019,
-0.035734084,
-0.017880376,
0.029680625,
0.18155049,
0.00026167216,
-0.013760289,
0.017093694,
-0.013286946,
-0.026667228,
-0.0015116985,
0.012366927,
-0.006946813,
0.004476761,
0.009220194,
-0.0114535745,
-0.014506971,
-0.0005729287,
0.03290736,
-0.011800248,
-0.017920377,
-0.0020467096,
-0.022373805,
0.006263465,
0.016320344,
-0.014586974,
-0.0014291968,
-0.009373531,
0.039174158,
0.0034834067,
-0.016987024,
-0.007153484,
0.011440241,
-0.01966708,
-0.020640435,
-0.011993586,
0.0114535745,
-0.009240194,
-0.026173884,
0.011006898,
-0.02800059,
-0.017707039,
0.0035600748,
-0.009433532,
0.0025783875,
0.04829435,
-0.00618013,
0.008220173,
-0.0115402425,
-0.0072268187,
0.011820248,
-0.0047901007,
-0.00061751297,
-0.02885394,
-0.040427517,
0.018400388,
-0.0047501,
0.0055467836,
-0.0030933984,
-0.008586847,
0.026333887,
-0.0011816915,
-0.011313572,
0.021347117,
-0.0133602815,
-0.00090085226,
-0.034694064,
0.012226924,
-0.017000359,
0.021040443,
-0.02250714,
-0.015240321,
0.0019350407,
-0.01948041,
0.012520264,
-0.015400324,
-0.031013986,
0.0153203225,
-0.0074001555,
-0.012606932,
0.011460241,
0.014213633,
0.014946981,
0.010080212,
0.015213653,
-0.0005108441,
-0.015853668,
0.009973543,
-0.019893752,
-0.030133968,
0.022720478,
0.010540222,
0.003543408,
-0.021867126,
-0.005530116,
-0.009573535,
0.005040106,
-0.000009114775,
0.013560286,
0.00044875944,
-0.015626995,
0.012280258,
-0.022480473,
-0.008813519,
-0.023547161,
0.06896145,
-0.014240299,
0.0056467853,
0.004343425,
0.01645368,
-0.0006954313,
0.021613788,
0.012593598,
0.009393531,
0.012373594,
-0.02265381,
-0.0020783772,
-0.015560327,
-0.0056634527,
0.0051101074,
-0.0009650203,
-0.029653957,
0.010506888,
0.0025983881,
-0.017533703,
-0.028533934,
0.015026983,
0.03528074,
-0.023453826,
-0.002368383,
-0.03528074,
0.017107027,
-0.013086942,
-0.031654,
0.0099868765,
-0.0020683769,
-0.015226987,
0.013600286,
0.0075134914,
-0.024520516,
0.010400219,
-0.027493913,
-0.024320511,
0.008993522,
-0.0189604,
-0.0010933563,
0.0042667566,
0.016933689,
-0.0064834696,
-0.03232068,
0.006810143,
-0.0072001517,
-0.021720458,
0.0011033566,
-0.02866727,
-0.024173843,
-0.029947298,
-0.010133547,
0.015186986,
-0.02597388,
-0.02158712,
-0.039227493,
-0.0012250257,
0.030187301,
-0.013693621,
0.0030883984,
-0.0013141943,
-0.0093335295,
-0.0031500664,
-0.023920503,
-0.16800353,
0.017427033,
-0.002833393,
-0.016280342,
0.023667164,
0.0019967086,
0.007666828,
-0.015706997,
-0.010220215,
0.018053712,
0.022387138,
-0.012120255,
-0.010426886,
-0.024853855,
0.0029817293,
0.0015883668,
-0.014106964,
0.049947716,
0.011406907,
0.014026962,
0.0066201393,
-0.029387286,
0.032480683,
-0.0021667122,
-0.010973564,
0.0018900398,
0.000091304006,
0.004393426,
-0.0005154275,
-0.004343425,
0.004890103,
0.017280364,
0.020720435,
-0.032240678,
0.005610118,
-0.0140136285,
-0.012780269,
0.010666891,
0.01044022,
0.0014950314,
0.031413995,
0.018733727,
0.012640266,
0.0015708664,
-0.01123357,
0.029867295,
0.021267114,
-0.013393615,
0.012420261,
0.007526825,
0.025480537,
-0.0013583619,
0.014200299,
0.022827147,
-0.00003669348,
-0.001439197,
0.015453658,
0.019453743,
-0.014946981,
0.003460073,
-0.004776767,
-0.04144087,
0.047414333,
0.00918686,
-0.017093694,
-0.018293718,
-0.030240636,
0.0016558681,
-0.026013881,
0.0020250427,
-0.012626932,
0.012733601,
0.036507435,
-0.0053334455,
0.028640602,
0.008533513,
-0.0013525285,
0.008840186,
-0.005163442,
-0.00918686,
-0.026387222,
0.011926917,
-0.018320385,
-0.017920377,
-0.00872685,
0.010300217,
0.0016183674,
0.012213591,
0.0007633494,
-0.009266862,
0.014640308,
-0.01641368,
0.007673495,
-0.031707335,
0.0012108588,
0.027547246,
-0.0061334623,
-0.0005695953,
-0.014493639,
-0.004220089,
0.0018233717,
-0.02188046,
-0.021933794,
0.015573661,
0.04965438,
0.0016967023,
-0.012453595,
0.007806831,
0.05328112,
-0.009560201,
-0.0051601087,
-0.0059467917,
0.0038034134,
-0.010400219,
-0.0028350595,
0.030800648,
-0.002648389,
-0.0012833603,
0.008006835,
-0.024373846,
0.06741475,
-0.012286925,
0.012626932,
-0.011760248,
0.0010633557,
-0.0084868455,
-0.12810937,
-0.030373972,
0.012473596,
0.013680288,
-0.006426802,
0.00018344136,
0.0015308656,
0.026373887,
-0.021653788,
0.042934235,
-0.024947193,
-0.02630722,
-0.015186986,
-0.0025717209,
0.0074134893,
0.0051934426,
0.004246756,
0.014600307,
-0.021613788,
0.037787464,
0.002821726,
0.0016058672,
0.0077868304,
-0.022600476,
0.012600265,
-0.023933837,
-0.02992063,
0.013080276,
0.0010733559,
0.017253697,
-0.003246735,
-0.0030583977,
0.0033567373,
0.00076876616,
-0.015666997,
-0.014360302,
-0.006056794,
-0.029333951,
0.027107237,
0.0012300259,
-0.019947086,
0.010786894,
0.027387243,
0.02472052,
0.00190004,
-0.013920293,
-0.018467056,
0.020240426,
0.01708036,
0.0013125276,
-0.014186965,
-0.025360534,
-0.039280828,
0.011913584,
-0.0062201307,
-0.027013902,
0.030640645,
0.019893752,
0.0045667626,
-0.016880356,
-0.0044900943,
0.014360302,
-0.0037067446,
0.009573535,
0.019267073,
-0.03117399,
-0.0053501124,
-0.045867633,
0.006253465,
-0.0024850522,
-0.0070934827,
0.008666849,
-0.010973564,
0.0077134958,
-0.030027298,
0.004256756,
-0.019440409,
0.0043900926,
0.011333572,
-0.038160805,
-0.0045667626,
-0.008166838,
0.030960651,
-0.017027024,
0.017707039,
0.0046867654,
0.0017200361,
-0.009886875,
0.0010541888,
-0.0206271,
-0.016747018,
0.046774317,
-0.015226987,
-0.018827062,
-0.014000295,
0.008346843,
-0.0016333677,
-0.0083268415,
0.02668056,
0.039760835,
-0.021840459,
-0.010706892,
-0.04309424,
0.019693747,
-0.0021667122,
-0.010026878,
0.0051267743,
0.021853793,
0.0056634527,
0.0033667374,
-0.010166881,
0.041680876,
-0.016387012,
0.03317403,
0.0036700773,
-0.0086801825,
-0.023733832,
-0.019893752,
0.0032400682,
-0.0041367537,
0.015360323,
0.0428009,
-0.009706871,
-0.0010366885,
0.01075356,
-0.0065801386,
-0.019093735,
-0.015520327,
-0.011446907,
0.019760415,
-0.018093714,
0.0010175214,
0.021720458,
-0.029573957,
-0.028907275,
0.003135066,
0.0025800543,
-0.020227091,
0.005530116,
0.022053797,
0.032000672,
0.037600793,
-0.022787146,
-0.022053797,
0.016920356,
0.000026159405,
-0.013760289,
0.012166923,
-0.04298757,
0.008213506,
0.0051034405,
0.0075001577,
0.026280552,
0.005123441,
0.01094023,
-0.017387033,
-0.012886938,
-0.0077134958,
0.001125857,
-0.0019117069,
-0.03232068,
-0.032160677,
0.012200257,
0.016213674,
0.025213864,
0.0037734127,
-0.017827041,
-0.016187007,
-0.01077356,
0.004633431,
-0.0032367348,
-0.02630722,
-0.014986982,
0.0029717293,
-0.0007900166,
0.0054601147,
0.01031355,
0.0049101035,
-0.020240426,
-0.0048467685,
0.014000295,
0.012186923,
0.0019450409,
0.0075468253,
-0.0011016899,
0.012306926,
0.018427055,
-0.013653621,
0.0062034638,
-0.007853499,
0.02040043,
0.013260279,
0.0015775332,
0.03704078,
0.028560601,
0.0174137,
0.0075068246,
0.0089268545,
0.0070001474,
-0.007493491,
0.01649368,
0.020187091,
-0.0053334455,
0.011000232,
-0.003258402,
-0.01413363,
-0.021973796,
0.023787167,
-0.033814047,
-0.02564054,
-0.016587015,
0.0050767735,
0.0070068142,
0.015853668,
0.016467012,
-0.003733412,
0.0030633977,
0.018760394,
-0.0009775206,
-0.017053692,
-0.008953522,
0.019867085,
0.006946813,
0.010913563,
-0.004626764,
0.028693937,
0.021040443,
-0.002553387,
0.04029418,
-0.040640853,
0.006570138,
-0.022960484,
0.03952083,
-0.016840354,
-0.042854235,
-0.0049034366,
0.00017031608,
-0.008753518,
0.010766894,
0.014493639,
-0.025173863,
0.054774486,
0.008740184,
-0.0049601044,
0.003990084,
-0.025840543,
0.028240595,
0.0065068034,
0.0066468064,
-0.006810143,
-0.027680583,
0.014453637,
-0.037840795,
0.027520578,
-0.017907044,
-0.035760753,
0.026813898,
-0.009193527,
-0.003275069,
0.0039167493,
-0.018987067,
0.027307242,
-0.0000010856348,
-0.002303382,
0.019427076,
-0.039200824,
-0.017653706,
0.021627123,
0.0027333908,
-0.0011066899,
0.0033500704,
0.0063468004,
-0.021253781,
-0.0174937,
-0.020800438,
0.019080402,
-0.018867064,
0.024627184,
0.0014633641,
0.0076534944,
0.00190004,
0.014106964,
-0.018173715,
-0.01204692,
-0.04301424,
-0.020213759,
0.0074868244,
0.00021937961,
-0.0094802,
0.0042000883
] |
PURPOSE OF REVIEW Greater understanding of the biology and genetics of urothelial carcinoma is helping to identify and define the role of molecules and pathways appropriate for novel-targeted therapies. Here, we review the targeted therapies that have been reported or are in ongoing urothelial carcinoma clinical trials, and highlight molecular targets characterized in preclinical and clinical studies. RECENT FINDINGS Trials in nonmuscle-invasive bladder cancer are evaluating the role of immunotherapy and agents targeting vascular endothelial growth factor (VEGF) or fibroblast growth factor receptor-3. In muscle-invasive bladder cancer, neoadjuvant studies have focused on | [
-0.02557589,
-0.015213016,
0.015160009,
-0.015570814,
-0.014802212,
0.009534638,
-0.025403617,
0.0037767505,
-0.03750247,
0.0009566112,
0.005277512,
-0.012231371,
0.00020126105,
0.014868471,
-0.019268055,
-0.0063972855,
0.033977505,
-0.0066192523,
-0.006205135,
0.005171498,
-0.019201795,
0.011164605,
-0.016789975,
-0.015531058,
-0.022315959,
0.018897004,
0.009647279,
-0.040338345,
-0.0022064175,
-0.0067252666,
-0.008116701,
0.016100883,
-0.020275187,
0.0014916508,
0.008090197,
0.0141263725,
0.015517807,
0.0093358625,
0.025085574,
-0.012357263,
0.022050923,
0.0017326671,
0.0051317425,
-0.00016802813,
-0.008090197,
-0.0076528895,
-0.0006381549,
-0.012794571,
-0.015809346,
-0.002420102,
0.0064834217,
0.026728792,
-0.016591199,
0.010435758,
-0.0019115659,
-0.0042571267,
0.021772636,
0.03191023,
-0.0019910764,
-0.012430147,
-0.018234417,
0.013351144,
-0.022634,
0.021640118,
-0.0072619626,
0.004078228,
-0.013980603,
0.011754308,
0.013450533,
-0.011032087,
0.02210393,
0.022885783,
0.0069240425,
-0.010236981,
0.03612429,
-0.021348579,
-0.03816506,
-0.023680888,
0.0012175051,
0.0032897484,
-0.0051317425,
-0.0022180127,
-0.010442384,
-0.008454621,
0.0059400997,
0.038006037,
-0.007321595,
-0.015570814,
-0.005638622,
0.0021103423,
0.0024962996,
0.0065695583,
0.0040682894,
0.011588661,
-0.02030169,
0.024568757,
-0.0173598,
0.019837879,
0.0077986587,
-0.044154853,
0.008527505,
0.0065927487,
0.0015703331,
-0.021441342,
-0.038695127,
0.010515269,
-0.010820059,
-0.007891421,
0.020314943,
0.0041014184,
0.00043772208,
0.029630927,
-0.01795613,
-0.015027491,
0.02338935,
-0.0011545593,
0.035435196,
0.015743086,
-0.005767827,
0.012357263,
0.0107604265,
-0.006705389,
0.031804215,
-0.012257875,
0.054438215,
0.0051284297,
-0.027378129,
0.007560127,
0.0043797055,
-0.00560218,
-0.0015686767,
0.012655428,
0.019533088,
0.007765529,
-0.018883754,
-0.01742606,
-0.021057041,
-0.006261455,
-0.020129418,
-0.031883724,
-0.0017475754,
0.017081514,
-0.02798771,
0.01583585,
-0.035249673,
0.0089515615,
0.023203826,
0.013636057,
0.008057068,
-0.008461246,
0.00042115737,
-0.03954324,
-0.0047772583,
-0.023349594,
-0.011522402,
0.012158486,
-0.01787662,
0.038218066,
-0.024462743,
0.007858291,
0.0031174757,
-0.0004662962,
0.028782815,
0.011548906,
0.014563681,
0.011807315,
0.021481097,
0.02451575,
-0.009309359,
0.004011969,
-0.0076661413,
0.042909186,
-0.024462743,
0.02036795,
-0.02920687,
0.012476529,
0.010488765,
0.02248823,
-0.01916204,
-0.0021103423,
-0.01728029,
0.009428625,
0.024250714,
-0.008547382,
-0.014046862,
0.014298645,
0.0196126,
-0.033765476,
-0.01195971,
-0.03357995,
0.0049793473,
0.025178337,
-0.004840204,
-0.0073679765,
-0.6331159,
-0.036839884,
0.012231371,
0.01509375,
0.005797643,
0.0151467575,
0.005668439,
-0.00837511,
-0.005708194,
0.0026934196,
-0.0075800046,
0.012721686,
0.0006671431,
-0.008143204,
-0.023402601,
-0.012728312,
-0.026304737,
-0.035064146,
0.011555532,
-0.013848085,
-0.007447487,
0.0030561863,
0.001711133,
-0.0014966202,
0.015385289,
0.030638061,
-0.0011810628,
-0.030426033,
0.009415373,
0.020831762,
-0.029524913,
0.024078442,
-0.011151353,
-0.016935745,
0.047891848,
0.0052874507,
-0.0016357637,
0.010521894,
0.0055259825,
0.03267883,
0.0026901066,
-0.0075402493,
0.0267818,
0.002067274,
-0.033553448,
0.04502947,
0.044313874,
-0.018737983,
0.0023886291,
-0.009382243,
0.031380158,
0.030267011,
-0.023097811,
-0.030214004,
0.0026785112,
-0.0034388308,
0.031433165,
-0.021520853,
0.0054762885,
-0.0132385045,
0.014245638,
0.01576959,
-0.0048435167,
-0.030638061,
-0.0005594726,
0.03251981,
-0.030346522,
0.01901627,
0.009673782,
0.03310289,
0.008891929,
0.037767507,
-0.0021153116,
-0.0108598145,
0.032016244,
0.05576339,
-0.010773678,
0.017267039,
-0.003975527,
-0.003932459,
0.015305779,
-0.0063972855,
-0.02436998,
0.024794037,
0.021547357,
-0.014590184,
-0.0143384,
0.012145234,
0.023574874,
0.011270619,
0.0036740494,
-0.011853696,
-0.030611558,
-0.057035558,
-0.0136228055,
0.024780784,
-0.0038430092,
0.023813406,
0.01165492,
-0.035435196,
-0.021534104,
-0.0121319825,
-0.0001862493,
-0.00027000453,
0.0032615885,
0.013821582,
-0.013218627,
0.015902108,
0.016471934,
-0.04044436,
0.031406663,
0.006241577,
-0.0048170136,
-0.010435758,
0.0010990675,
-0.026702289,
-0.019533088,
0.0039059552,
0.013072858,
-0.037157923,
-0.010780304,
-0.0068379063,
-0.0009806299,
-0.023627881,
0.0071559483,
-0.0065563065,
0.0073746024,
-0.03145967,
-0.01765134,
-0.016736967,
0.0141926315,
-0.03917219,
0.023137566,
-0.017002003,
0.0092431,
-0.0020838387,
0.00029650805,
0.00456523,
-0.020566726,
-0.016100883,
-0.026821556,
-0.02573491,
0.024780784,
0.017797109,
-0.005668439,
-0.0052874507,
-0.011555532,
0.007672767,
-0.006314462,
-0.007871543,
0.012582542,
-0.005535921,
-0.0032731837,
0.002819311,
0.027378129,
-0.012854204,
0.008322103,
-0.027722673,
-0.00826247,
-0.0062515163,
0.00016895989,
-0.0014618344,
-0.008514253,
-0.0026221913,
0.0009309359,
-0.009150337,
-0.0066424427,
0.013490288,
-0.010945951,
-0.028305752,
-0.009673782,
-0.020738998,
-0.010051457,
0.022660503,
0.0005901173,
-0.0015877261,
-0.013649309,
-0.011263993,
-0.00852088,
0.0056982553,
-0.0024681396,
-0.0032963743,
0.00084894063,
0.013715568,
0.009932191,
0.017028507,
0.027126346,
0.0030992546,
0.019109033,
0.020235432,
-0.017810361,
0.002176601,
-0.029604424,
0.034984637,
0.000885383,
-0.0031986427,
0.021719629,
-0.0025708408,
0.003100911,
0.020195676,
0.02896834,
-0.02777568,
0.026198722,
-0.0040318468,
0.023826659,
-0.0120325945,
0.014749205,
-0.007984183,
0.0043929573,
-0.019148787,
0.014815464,
0.010183975,
-0.039251704,
-0.0027381442,
0.00026379278,
-0.012145234,
-0.010707419,
-0.023283336,
-0.01787662,
0.0015330625,
-0.012801196,
0.012165112,
0.006576184,
-0.014537177,
-0.0151467575,
0.016909242,
-0.00807032,
0.02835876,
0.013152368,
-0.014815464,
0.018446445,
0.030373026,
0.012854204,
0.00026834806,
0.015663575,
0.0047474415,
0.019268055,
-0.0024813914,
0.034905124,
-0.0018038953,
0.014523925,
0.000079821126,
0.0015827566,
0.006857784,
0.02391942,
-0.0054729753,
0.014351652,
0.0143384,
-0.0027464265,
0.010369499,
-0.00009193406,
0.010084586,
-0.0076992703,
-0.018154906,
-0.005863902,
-0.035408694,
-0.002956798,
0.018128403,
0.052344438,
0.0044890326,
0.018910257,
-0.0026751983,
-0.0041544256,
0.007467365,
-0.004286943,
0.028305752,
0.026954072,
-0.016803227,
-0.011303748,
0.01938732,
-0.012927088,
-0.0112109855,
0.020261936,
-0.016922493,
0.015199765,
0.006261455,
0.01705501,
0.009408747,
0.0036707364,
0.011601913,
-0.017240535,
-0.024807287,
0.023495365,
0.010601405,
0.0061421893,
-0.005390152,
-0.011197734,
0.0042041196,
-0.029975472,
-0.009375618,
0.02596019,
-0.0046513663,
-0.011098346,
0.010667664,
0.0018651847,
-0.0039357715,
0.013861337,
-0.015570814,
-0.0020275188,
-0.002854097,
0.010236981,
-0.016206898,
0.004194181,
-0.00882567,
0.022276202,
0.024608511,
-0.0114296395,
-0.0014386438,
-0.010813433,
-0.026145715,
-0.0067087016,
-0.0030048357,
-0.0074209836,
-0.020725748,
-0.009753292,
-0.0040318468,
0.030638061,
0.005168185,
0.034825616,
0.021308824,
0.0043697665,
-0.03310289,
-0.0069174166,
-0.006145502,
0.031777713,
0.019360816,
0.0033742285,
0.023442358,
0.03440156,
0.0049197148,
-0.015345534,
-0.011926581,
0.025191588,
-0.038615618,
-0.023137566,
-0.00024246573,
-0.0050886744,
-0.0057479492,
0.024118196,
0.042962193,
-0.020089662,
-0.008620268,
-0.011138101,
-0.005986481,
-0.0069174166,
-0.0057877046,
0.047547303,
0.010733923,
0.03713142,
-0.0041179834,
-0.0018569024,
0.015292527,
0.01909578,
-0.0071692,
-0.0150804985,
0.00078558066,
0.016008122,
0.031724706,
-0.028915333,
-0.024303721,
0.011641668,
-0.010177349,
0.018247668,
0.012814448,
0.02030169,
0.0080305645,
0.014431163,
0.008023938,
-0.013702316,
-0.03938422,
0.014947982,
0.0076926444,
0.011283871,
-0.014576932,
-0.0069903014,
-0.009514761,
0.0025095514,
-0.026344491,
0.0184862,
0.013185497,
0.003210238,
-0.012019343,
0.008540757,
-0.010482139,
-0.0046911216,
-0.003072751,
0.00347196,
-0.016591199,
-0.016233401,
-0.0054530976,
-0.017479066,
0.008885303,
-0.021361832,
0.009117208,
0.009567768,
-0.014537177,
-0.018022388,
0.014364904,
0.02022218,
0.0011504181,
0.024529,
-0.009170216,
-0.015226268,
0.025032567,
-0.010164097,
-0.00848775,
0.003288092,
-0.040020306,
-0.0011023805,
-0.0020440833,
-0.014113121,
-0.003478586,
-0.024250714,
0.028332256,
0.008626893,
-0.0071493224,
0.021706376,
-0.01105859,
0.01003158,
0.00088703947,
0.012748189,
0.00375356,
-0.0028872264,
-0.021308824,
-0.0096870335,
-0.03676037,
-0.004151113,
-0.05062171,
-0.010680916,
-0.015809346,
0.010130968,
0.013689064,
0.00025903044,
-0.0028358758,
0.0031456356,
-0.00588378,
0.009256352,
-0.007288466,
0.007712522,
-0.0026785112,
-0.035673726,
0.010972454,
0.01576959,
-0.015372037,
0.016816478,
0.0017757354,
0.041000932,
0.014431163,
-0.013265008,
0.01089957,
0.0021583799,
0.0054464717,
-0.016100883,
0.007831788,
-0.0048435167,
0.043545272,
0.02332309,
-0.029100858,
0.0019943893,
-0.021149803,
-0.011522402,
0.018459696,
-0.008428117,
-0.0068114027,
-0.007613134,
0.02316407,
0.013026477,
-0.00040355738,
0.03387149,
-0.03721093,
-0.007705896,
0.020235432,
0.0013624462,
0.003856261,
-0.009037698,
0.018923508,
-0.015292527,
-0.0030114616,
-0.0054166554,
-0.027219107,
0.0061289375,
-0.010985706,
0.03877464,
0.038244568,
0.013059606,
-0.002776243,
-0.009567768,
0.02248823,
0.011032087,
0.003422266,
-0.006755083,
0.020089662,
-0.027060086,
0.02505907,
0.00079179247,
-0.015557562,
0.031115124,
-0.012310882,
0.026437255,
0.0064105373,
-0.00060129847,
0.017558577,
-0.02248823,
-0.04105394,
-0.05213241,
0.011051965,
-0.003200299,
-0.009720163,
-0.051257793,
-0.00347196,
0.0196126,
0.022090677,
-0.004028534,
-0.0099056875,
0.0070631863,
-0.015438296,
0.012556039,
-0.01554431,
0.019148787,
0.0065198643,
0.010250233,
-0.0153985405,
-0.013781827,
0.0033775414,
0.009143712,
-0.0017525448,
0.013569798,
-0.00082450773,
-0.0055856155,
-0.01044901,
-0.01210548,
-0.008891929,
0.0153322825,
-0.038721632,
-0.007321595,
0.011774185,
-0.016100883,
-0.019639103,
0.00988581,
0.02232921,
-0.017757354,
0.013119238,
-0.010369499,
0.00008717171,
0.0129867215,
-0.009879184,
0.016180394,
-0.022567742,
0.041027438,
0.024939805,
-0.0061587538,
-0.02036795,
-0.00943525,
-0.002416789,
0.011919955,
0.021269068,
0.028305752,
0.014232386,
-0.031406663,
-0.0030164311,
0.0061852573,
-0.009965321,
-0.037263937,
0.033076383,
0.037528973,
0.0005694114,
-0.0030594992,
-0.0354617,
-0.013437281,
0.019705363,
-0.008467873,
-0.015053995,
-0.0039655883,
-0.009826178,
-0.026066205,
0.026609527,
-0.0066225654,
0.019970397,
-0.0020092975,
-0.0056850035,
-0.004296882,
-0.01893676,
0.004505597,
0.002201448,
-0.0042074327,
0.01938732,
0.0017608271,
-0.0083486065,
0.0040517244,
-0.021520853,
0.026516765,
-0.011297123,
0.0022395467,
0.043068208,
-0.024131449,
0.0026056266,
0.010097838,
0.0012887333,
0.0023902855,
-0.018446445,
-0.0005072938,
-0.019731864,
-0.03718443,
-0.0151467575,
0.020579977,
0.014417911,
-0.010773678,
-0.0029816453,
-0.0124168955,
-0.0071559483,
-0.011018835,
-0.0015338908,
-0.0011437922,
-0.038907155,
-0.023111064,
-0.005217879,
0.022726763,
0.03718443,
0.008467873,
-0.010680916,
0.015040743,
0.033818483,
-0.01003158,
-0.011191108,
-0.0040616635,
-0.0036740494,
-0.0148287155,
-0.009614149,
-0.022779768,
-0.03350044,
0.00610906,
-0.024383232,
-0.038006037,
-0.017253786,
-0.026172219,
-0.002391942,
-0.0013665874,
-0.02859729,
0.01877774,
0.019148787,
0.030585054,
-0.01675022,
-0.009084079,
0.028279249,
-0.0138083305,
0.0014949638,
0.027298618,
-0.021746133,
-0.0011893451,
0.011707927,
-0.014325148,
-0.008017313,
-0.020871516,
-0.0029717064,
-0.045930587,
-0.004578482,
-0.007606508,
-0.01637917,
0.022143684,
-0.004896524,
-0.017386304,
0.010535146,
0.014855219,
-0.018459696,
0.011972962,
-0.0032582756,
-0.0057313847,
0.022885783,
-0.038668625,
0.0081299525,
-0.014629939,
-0.018804243,
-0.043412752,
-0.007944428,
-0.015372037,
0.02835876,
0.01086644,
0.009733415,
-0.011615165,
-0.007500494,
-0.045214992,
0.0009069171,
0.014417911,
0.01916204,
0.0071493224,
0.0061223116,
-0.0083486065,
0.019480081,
-0.019109033,
-0.005214566,
0.013212001,
-0.0056485613,
0.03108862,
0.002063961,
0.035594217,
0.0024929866,
-0.036786877,
-0.033606455,
0.012006091,
-0.0059169093,
-0.017823612,
0.016405674,
-0.013636057,
0.014921478,
-0.012224745,
-0.0030528733,
-0.015570814,
0.029551417,
0.022541238,
-0.01742606,
-0.01207235,
0.011124849,
-0.01316562,
-0.006314462,
0.0069704237,
0.009912314,
0.017161025,
0.025893932,
-0.0042273104,
-0.019029522,
-0.0029717064,
0.0026520079,
0.00021679045,
0.026039701,
0.0058572763,
0.025098827,
-0.00068080897,
0.00069199014,
-0.0018386812,
0.010435758,
-0.010038205,
-0.0029236688,
-0.0015446579,
0.010965829,
-0.013516791,
-0.02211718,
-0.020964278,
-0.020381201,
-0.007613134,
0.01464319,
-0.0062780194,
-0.015941862,
0.002155067,
-0.005767827,
-0.01637917,
-0.018340431,
-0.006712015,
-0.021295572,
-0.027828688,
-0.016591199,
0.008116701,
-0.0060196104,
0.008222715,
-0.009826178,
-0.0043200725,
0.035064146,
0.0051980014,
-0.012966843,
-0.027298618,
0.0078052846,
0.18425243,
-0.014974484,
0.009123834,
0.019215047,
-0.00852088,
0.00852088,
0.041716527,
-0.014046862,
-0.0066788853,
0.008388362,
0.033394426,
-0.0043830182,
-0.010515269,
-0.005108552,
0.020566726,
-0.022209944,
-0.020579977,
-0.022315959,
-0.010203852,
-0.006791525,
-0.017108018,
-0.006029549,
0.027219107,
0.012052473,
0.016127387,
-0.0099388175,
-0.009163589,
0.008779288,
0.029471906,
-0.009256352,
-0.0126355495,
0.01787662,
0.009395495,
-0.0063244007,
0.02165337,
0.0031406663,
-0.025681904,
-0.019003019,
-0.014735953,
-0.0042703785,
-0.0056121186,
0.015425044,
-0.021693125,
-0.0043068207,
-0.002797777,
0.015968366,
-0.03193673,
-0.0062084477,
-0.00043896443,
-0.003023057,
-0.046540167,
0.027245611,
0.005608806,
0.006804777,
-0.019758368,
-0.0018320553,
0.030797081,
-0.0068180286,
0.008819044,
0.022355713,
-0.018684976,
-0.0066192523,
-0.030134493,
0.026980575,
-0.007792033,
0.019201795,
-0.016617702,
0.010091213,
0.04012632,
-0.0069836755,
0.0006344278,
-0.01403361,
-0.018234417,
0.016842982,
0.0071426965,
0.002292554,
0.035249673,
0.013662561,
-0.00096572173,
-0.000113985814,
0.0040484117,
0.009170216,
-0.0010791899,
-0.0078450395,
-0.018605465,
-0.03532918,
0.0002642069,
0.017624836,
0.012469903,
0.006480109,
-0.008613641,
0.007189078,
-0.008997942,
-0.011502525,
0.017810361,
0.010150845,
-0.002151754,
0.013145742,
0.0037071789,
0.013006599,
-0.031221138,
0.06673584,
0.014696198,
0.015411792,
0.0071294447,
0.016233401,
-0.005810895,
0.009879184,
0.005333832,
-0.015000988,
0.029551417,
-0.031274144,
0.0054232813,
-0.014046862,
-0.004071602,
0.018618718,
0.00016036695,
-0.018539207,
0.036786877,
-0.0053570224,
-0.0058075823,
-0.018048892,
0.002229608,
0.022170188,
-0.017147772,
-0.00577114,
-0.026052954,
-0.0036077907,
0.012039221,
-0.015570814,
-0.0043929573,
-0.0006145502,
-0.001986107,
-0.0026503513,
0.0141926315,
-0.0009872558,
0.0124168955,
-0.0133378925,
-0.033208903,
0.02179914,
0.0016780037,
0.01286083,
0.0147624565,
0.031592187,
0.004505597,
-0.0069836755,
0.026874563,
-0.0054630367,
-0.014590184,
-0.014311897,
-0.003428892,
-0.019056026,
-0.009123834,
-0.014060114,
0.024025435,
-0.03326191,
-0.014669694,
-0.022819525,
-0.012337385,
0.013549921,
-0.027802184,
0.0023024927,
0.039569743,
-0.016485184,
-0.008143204,
-0.0038960164,
-0.16623004,
0.021587111,
0.029180368,
-0.018115152,
0.03811205,
0.0033841673,
0.0016208554,
0.000016538814,
-0.010462262,
0.007970931,
0.03249331,
-0.004614924,
-0.031221138,
-0.022554489,
-0.0028938523,
0.033208903,
-0.018737983,
0.029524913,
0.013689064,
0.016100883,
0.014166128,
0.001128884,
-0.000021922338,
-0.010349622,
-0.004608298,
-0.007122819,
-0.0026023136,
-0.030903095,
-0.020023404,
0.002314088,
-0.0071493224,
-0.0023256831,
0.02361463,
-0.007977557,
0.024542253,
0.019307809,
-0.020142669,
0.009952069,
-0.024157953,
0.00750712,
0.033182397,
0.028014213,
0.024873547,
-0.0021136552,
-0.025748163,
0.011151353,
0.018459696,
0.0059003443,
0.013927596,
0.0021086857,
0.029074354,
0.018393438,
-0.0020954339,
-0.005499479,
0.02920687,
0.009846055,
0.0031903603,
-0.007553501,
0.017081514,
0.0018320553,
-0.026158966,
-0.0015811002,
0.021679873,
0.018737983,
-0.016909242,
-0.038721632,
-0.0056585,
0.010608031,
-0.020129418,
-0.009786422,
-0.030054983,
-0.028782815,
0.01879099,
-0.00969366,
0.023588127,
0.0084479945,
0.026424002,
0.010362874,
-0.0075203716,
0.0008812418,
-0.025297603,
-0.009402121,
-0.012880707,
-0.016034625,
0.005048919,
0.033685964,
-0.013530043,
0.008090197,
-0.009004569,
-0.0029220122,
0.019586096,
-0.020738998,
-0.012198241,
-0.03108862,
0.018101899,
0.025072323,
0.021918405,
0.015000988,
-0.012980095,
-0.016604451,
0.031963237,
-0.016339416,
-0.015385289,
0.0019612599,
0.029710438,
-0.006559619,
0.0020092975,
0.0027911512,
0.03198974,
0.011741056,
-0.025072323,
-0.0059069702,
0.0066093137,
0.015729835,
-0.021467846,
0.0061653797,
0.013351144,
0.0007445831,
-0.007884795,
-0.040470865,
0.056081433,
0.009441877,
0.0399938,
0.024847044,
0.00403516,
-0.022236448,
-0.11417713,
-0.03289086,
0.010687541,
0.009044324,
-0.023601377,
0.010674289,
-0.0062846453,
0.028438268,
-0.021560607,
0.026980575,
-0.013848085,
-0.005834086,
-0.015385289,
-0.015027491,
0.010396003,
-0.01758508,
0.0017227284,
-0.010667664,
-0.034878623,
0.025390366,
-0.007931177,
0.012476529,
-0.014391407,
-0.02535061,
-0.003422266,
0.0038363836,
-0.024886798,
0.00456523,
0.008169708,
-0.0023621256,
-0.0000015335285,
-0.004942905,
0.016935745,
-0.02588068,
-0.017850116,
-0.02354837,
-0.00837511,
-0.038059045,
0.020142669,
-0.03893366,
-0.022793021,
-0.002194822,
0.024025435,
0.004515536,
-0.0071294447,
-0.020195676,
-0.031751208,
-0.005121804,
0.034984637,
-0.009521387,
-0.028888829,
-0.024661519,
-0.026211973,
-0.012118732,
0.010548398,
-0.013675813,
-0.043412752,
-0.015199765,
-0.022368964,
-0.0016026343,
-0.035885755,
-0.008328729,
-0.018300675,
0.01877774,
-0.003422266,
-0.003425579,
0.0015835849,
-0.043280236,
0.019758368,
-0.025271099,
0.0047010607,
0.00044600441,
-0.031804215,
0.014576932,
-0.01176756,
-0.000058959962,
0.012198241,
-0.001873467,
0.022474978,
-0.018512703,
-0.02240872,
-0.011880199,
0.02052697,
-0.018340431,
0.030850088,
0.016869485,
-0.007917925,
-0.022567742,
0.01636592,
-0.00088207005,
0.007672767,
0.02904785,
0.010051457,
-0.04881947,
0.005615432,
0.0061223116,
-0.0064966734,
-0.017002003,
0.026450505,
0.042511635,
-0.0046016723,
-0.0004385503,
-0.06164717,
0.01916204,
-0.0073017175,
-0.01901627,
0.005443159,
-0.0032218331,
0.019268055,
0.00059260195,
0.01086644,
0.011860322,
-0.028517779,
0.027749177,
0.0041908678,
-0.0010692511,
-0.032228272,
-0.007242085,
0.029180368,
0.0020507092,
-0.003425579,
0.0399938,
0.006486735,
-0.014947982,
0.01591536,
0.0043266984,
0.004631489,
0.008123327,
-0.0049727215,
0.017492319,
-0.011760933,
-0.024131449,
-0.00035448448,
-0.017465815,
0.0086799,
0.0053371447,
-0.010972454,
-0.013059606,
0.0021004034,
0.021401586,
0.0046844957,
0.022673756,
0.0031423226,
-0.031645194,
0.02007641,
-0.003029683,
-0.0071426965,
0.0037966282,
-0.041239467,
0.012516283,
-0.028544283,
-0.003972214,
0.012430147,
0.0028143418,
-0.00024184455,
-0.023521867,
-0.005704881,
0.012960218,
-0.019281305,
-0.003347725,
-0.029524913,
-0.006791525,
0.026052954,
0.025589142,
-0.020646237,
0.010495391,
-0.007083064,
0.0038198188,
-0.027881695,
0.019029522,
0.044737928,
-0.025363863,
-0.01109172,
-0.002267707,
-0.016180394,
0.010700793,
-0.005347084,
0.007765529,
-0.017253786,
0.00473419,
-0.005055545,
0.019824628,
0.013119238,
0.014046862,
-0.001114804,
0.015040743,
0.018923508,
-0.0041676774,
0.005486227,
0.019890886,
0.008759411,
-0.016246654,
0.00818296,
0.015107002,
0.037767507,
0.017240535,
0.011986214,
0.029895963,
0.012874082,
0.0068180286,
0.0045254747,
0.03599177,
-0.0036011648,
0.015941862,
0.006784899,
-0.017134521,
0.0009822864,
0.009249726,
-0.0316982,
-0.0126355495,
-0.02232921,
0.014086617,
0.019586096,
0.015650325,
0.00893831,
-0.014470918,
-0.0066060005,
0.012794571,
-0.013265008,
-0.012681931,
-0.012549413,
0.04709674,
-0.0006240749,
0.010468887,
0.0016780037,
0.0042670653,
0.0036707364,
0.0098725585,
0.019824628,
-0.0042239972,
0.029842956,
-0.021719629,
-0.0009798018,
-0.031592187,
-0.018009137,
-0.014431163,
0.005810895,
-0.023654385,
-0.0018602153,
0.015875604,
-0.006072617,
0.07855641,
0.010945951,
-0.023111064,
-0.015067247,
-0.027961206,
0.018751236,
0.021918405,
0.012774693,
-0.0070565604,
-0.038827647,
0.0046182373,
0.017770605,
0.012450025,
-0.03938422,
-0.018618718,
0.021931658,
-0.002663603,
0.010005076,
-0.0027563653,
-0.0060063587,
0.012595794,
-0.023508616,
-0.0052543213,
0.01252291,
-0.030240508,
-0.0032897484,
0.009534638,
0.0038297577,
0.012675305,
-0.03304988,
-0.008958187,
-0.0059566647,
0.0007363007,
-0.021030538,
0.023111064,
-0.012092228,
0.009958695,
-0.032016244,
0.021759383,
0.028279249,
0.009528013,
0.031883724,
-0.011085094,
-0.023217076,
-0.01637917,
-0.027431136,
-0.026238477,
-0.017068261,
0.022474978
] |
Nitrosoglutathione [(GSNO), 500 nmol/l] relaxed the norepinephrine precontracted rat aortic rings. The relaxation effect was pronouncedly enhanced by H2S- and HS−-donor NaHS (30 μmol/l) at 7.5 pH but not at 6.3 pH. To study molecular mechanism of this effect, we investigated whether NaHS can release NO from NO donors. Using an electron paramagnetic resonance spectroscopy method of spin trap and by measuring the NO oxidation product, which is nitrite, by the Griess reaction, we report that NaHS | [
-0.0030518228,
0.0027142318,
0.0070151417,
-0.021889402,
-0.019566776,
0.021740861,
-0.01872955,
-0.012659663,
-0.042374425,
-0.005269796,
0.0099926945,
0.000020413707,
-0.010708387,
-0.0005165143,
0.0075755427,
-0.0065627694,
0.03370509,
-0.0016027134,
0.0017656011,
0.0020424258,
-0.013152546,
0.0015520747,
-0.0072109443,
-0.003497443,
0.0073662363,
-0.0028053813,
0.028897792,
-0.030950345,
-0.018594513,
-0.004992971,
-0.000114147966,
-0.0055972594,
-0.024968233,
-0.021983927,
0.0009731061,
0.002292243,
-0.010060213,
0.00045912378,
-0.005141511,
0.006880105,
-0.0013512081,
-0.016717508,
0.012207291,
0.010134483,
-0.007683572,
-0.0008954602,
-0.0017149624,
-0.0233613,
0.0023226263,
0.030734288,
0.022159474,
0.00061905757,
0.0032239943,
0.012686671,
-0.0007076752,
0.0017689769,
0.019080644,
0.024968233,
0.0008794246,
-0.02941093,
-0.009391782,
-0.0075417836,
-0.032327715,
0.019850353,
0.00068952964,
-0.009702366,
-0.014232838,
-0.011937219,
-0.01664999,
0.0020660572,
0.012349079,
0.032246694,
-0.028141588,
0.009459301,
0.02473867,
-0.010688132,
-0.028843777,
-0.007629557,
0.006741693,
-0.01728466,
0.029059835,
-0.02340181,
-0.026156552,
0.014286852,
0.026642684,
0.00730547,
-0.0070218933,
0.010235759,
-0.023226263,
-0.013571159,
0.03694596,
0.055797044,
0.01624488,
-0.003936311,
-0.016906558,
0.01847298,
-0.014935027,
0.022483563,
-0.018094879,
-0.01887809,
-0.011835941,
-0.024900714,
0.0062251785,
-0.011127,
-0.00730547,
-0.012349079,
0.0012127957,
-0.008973169,
0.009479556,
-0.0064884997,
-0.015853275,
0.022348525,
-0.020228455,
-0.013334845,
0.0021926537,
0.0051752706,
0.038080268,
0.005195526,
-0.00023188283,
-0.018810572,
-0.0040004537,
-0.0015183156,
0.028789762,
-0.021754365,
0.01386824,
0.01764926,
-0.013429371,
-0.025710933,
-0.0061509083,
-0.0039633187,
0.0035075708,
0.0100534605,
0.010195249,
0.018959112,
-0.01783831,
0.047046684,
-0.0037540123,
-0.0019310206,
-0.0070489007,
-0.03370509,
-0.0011098305,
0.022037942,
-0.0066370396,
-0.018040864,
0.0014913083,
0.017959842,
0.014394881,
0.011005468,
0.010289774,
0.0023546973,
0.017527726,
-0.028573705,
0.016852545,
-0.0037911471,
0.00055153936,
0.016339406,
-0.011471343,
0.027209837,
-0.024225531,
-0.0096821105,
-0.00007463927,
-0.02525181,
0.022996701,
-0.031625528,
-0.012227547,
0.0137939695,
0.01675802,
0.002255108,
-0.007940141,
-0.01539415,
-0.032408737,
0.037297055,
-0.006812587,
0.009013681,
0.013456378,
0.011964226,
0.019148163,
-0.0014744288,
0.01847298,
-0.015434662,
-0.009263498,
0.012916232,
0.023712393,
0.01624488,
0.007271711,
0.01164689,
0.02418502,
-0.0072311996,
0.009155469,
-0.017109113,
-0.024347065,
0.0058909636,
-0.025724435,
-0.026953267,
-0.6352113,
-0.026993778,
0.015191596,
-0.01728466,
0.008095433,
0.008696345,
0.012099262,
0.01658247,
-0.017176632,
0.034191217,
-0.02951896,
0.026440129,
0.0072109443,
-0.009877914,
-0.01097846,
-0.02444159,
0.0001428432,
0.01172116,
0.040808003,
-0.010283022,
-0.010195249,
-0.014799991,
-0.003983574,
-0.008041418,
0.05501383,
0.033867132,
0.000036343783,
-0.014962034,
-0.020268966,
0.020998161,
0.007028645,
0.027169326,
0.007865871,
0.018837579,
0.04688464,
-0.034434285,
-0.009722621,
0.034407277,
-0.0030383193,
0.02499524,
-0.018918602,
-0.001843247,
0.0072852145,
-0.012652911,
-0.006289321,
0.017824806,
0.0068564736,
-0.0075822943,
-0.00882463,
0.0067214374,
0.011289044,
-0.008615323,
-0.0030788302,
0.029275894,
0.008770615,
-0.009108206,
0.01097846,
-0.009972439,
-0.0039666947,
0.014556925,
0.013618422,
-0.0060698865,
-0.01008722,
-0.025157284,
-0.01294324,
0.012416597,
-0.02510327,
0.0046553803,
0.01431386,
0.02648064,
0.024563123,
0.02951896,
-0.0019310206,
0.0053609456,
0.0101817455,
0.036702897,
-0.006660671,
0.027061297,
-0.011626635,
0.012490868,
-0.0072041927,
0.007413499,
-0.008338498,
-0.0055432445,
0.022010935,
0.0033337113,
-0.027304363,
0.01068138,
0.005911219,
-0.0068362183,
0.018526996,
0.015934296,
-0.0146649545,
0.0035312022,
-0.011336307,
0.027871516,
0.003347215,
0.004446074,
0.010566599,
-0.008797622,
-0.023050714,
-0.0072649587,
0.017743785,
-0.01654196,
0.009405286,
-0.0014145063,
-0.05077369,
0.0006675862,
0.04164523,
-0.016717508,
0.028141588,
0.005310307,
-0.013348349,
-0.01134981,
-0.018040864,
-0.023374803,
0.009128462,
0.0020458016,
-0.013766962,
-0.024198525,
-0.017973347,
-0.004142242,
0.008034666,
-0.0034333006,
0.0018415591,
0.021011665,
-0.01813539,
-0.008986673,
-0.024225531,
-0.0047431537,
0.0070826598,
0.0051651425,
0.013348349,
-0.016312398,
0.028870784,
-0.0016972389,
0.03627078,
0.0038890487,
0.0058538285,
-0.021457285,
-0.037648153,
-0.00020033917,
-0.021052176,
-0.0014828686,
-0.0075552873,
-0.015866779,
-0.018445974,
-0.0017909204,
-0.0058369488,
0.0018668784,
0.0063129524,
0.002629834,
-0.023158744,
0.02032298,
-0.010229008,
-0.0030923337,
-0.008021163,
-0.01253813,
-0.025616407,
0.005840325,
0.009033936,
0.0248467,
-0.037026983,
-0.0023530095,
-0.03835034,
-0.029167864,
0.006761948,
0.03157151,
-0.00072160084,
-0.024104,
-0.0033657826,
-0.03167954,
-0.0019884112,
0.0048275515,
0.0039768224,
0.0076093017,
-0.0070826598,
-0.01060711,
-0.0062555615,
0.007852367,
0.0038485376,
-0.0033708464,
-0.020606557,
0.00443257,
0.050989747,
0.008574812,
0.010546343,
0.01093795,
-0.01698758,
0.019620791,
-0.025913486,
0.019674804,
-0.03494742,
0.014705465,
-0.010850175,
-0.028735748,
0.02355035,
-0.031274434,
0.0070489007,
0.031355456,
0.008635579,
0.008514046,
0.018351449,
-0.008541053,
0.02136276,
0.0051685185,
-0.01290948,
-0.009688863,
0.0015605146,
0.009094702,
0.011727912,
-0.0038958003,
-0.009844154,
-0.015124078,
0.0020390498,
0.008054921,
-0.011579372,
-0.0050841207,
0.007987403,
-0.026291588,
0.018864587,
-0.019364221,
0.003990326,
0.0019259568,
-0.019391228,
0.008682841,
0.023374803,
0.011235029,
0.00045194998,
0.0013799033,
-0.024347065,
-0.008041418,
0.013739955,
-0.020890133,
0.01405729,
-0.009277001,
0.012686671,
-0.01598831,
0.023023708,
0.02822261,
-0.0012372711,
-0.0073932433,
0.018513491,
-0.0111134965,
0.018229915,
-0.015529187,
0.020525534,
0.023415314,
-0.0036763663,
0.018932104,
-0.023739401,
0.030032098,
-0.00662016,
-0.00018029471,
0.009884665,
0.009324264,
0.0072109443,
0.034137204,
0.020295972,
0.012558386,
0.00882463,
0.024765678,
0.032030635,
-0.043562748,
-0.0072987177,
0.0061070216,
0.012754189,
0.022470059,
0.00062327745,
-0.0028357645,
-0.005796438,
0.0043346686,
-0.016852545,
-0.019161666,
0.02080911,
-0.001390875,
0.014975538,
0.021322249,
0.02562991,
0.0057626786,
-0.0058909636,
-0.014151815,
0.04132114,
0.00413549,
-0.009020432,
-0.008439776,
-0.013085028,
0.006269065,
-0.007474265,
0.021524804,
0.005485854,
0.03000509,
0.001579082,
0.011977729,
-0.023091227,
-0.047667854,
0.005573628,
0.006660671,
0.03059925,
-0.00041143905,
0.0077916007,
-0.003414733,
-0.030059105,
-0.009553826,
0.01947225,
-0.0009140277,
-0.004807296,
-0.012065503,
0.017743785,
-0.0084330235,
0.02822261,
0.016217873,
-0.0068227146,
-0.008223717,
-0.00043422644,
0.006353463,
-0.009668607,
-0.006579649,
0.0113093,
-0.013368605,
-0.010910942,
-0.035001438,
-0.0019377725,
-0.020458017,
0.029816039,
0.011194519,
-0.006215051,
0.017527726,
-0.004513592,
0.00849379,
0.009614592,
-0.01947225,
0.013253824,
0.0121735325,
0.0065222587,
0.016663494,
0.0090609435,
0.002376641,
0.004614869,
0.0111742625,
0.0051347595,
-0.01658247,
-0.018594513,
0.012963495,
0.0028745877,
-0.000376625,
-0.0058065658,
0.02614305,
0.017905828,
0.008169703,
0.016379917,
0.01887809,
0.016042326,
-0.022632102,
0.0061070216,
0.020701082,
0.01590729,
-0.016325902,
-0.029464945,
-0.024576627,
-0.0055466206,
0.016866047,
0.019796338,
-0.0046418766,
-0.0053710733,
0.0063635907,
0.005907843,
0.019674804,
-0.01431386,
-0.029924069,
0.010438315,
0.010418059,
-0.024279546,
0.004618245,
0.011397073,
-0.026872246,
-0.0053271865,
-0.02314524,
0.01031003,
-0.0035413299,
-0.0053913286,
-0.01987736,
-0.0062623136,
-0.011133752,
-0.022726627,
-0.0200259,
0.031733558,
-0.014691961,
-0.01420583,
-0.018310938,
-0.010823168,
-0.0082507245,
-0.03378611,
-0.00017101095,
0.02773648,
-0.01773028,
-0.03843136,
0.00093512714,
0.047343764,
-0.010127731,
0.0063433354,
0.000979858,
-0.006626912,
0.02618356,
-0.01887809,
-0.018202908,
-0.003117653,
-0.020647068,
0.019148163,
0.015299625,
0.0075687906,
0.0050942483,
-0.01906714,
-0.039403625,
0.026345603,
-0.026966771,
0.015043056,
-0.018945608,
-0.007224448,
0.003652735,
0.02091714,
0.02752042,
0.0017470336,
0.010958205,
-0.0019462123,
-0.02737188,
-0.00048191118,
-0.026912756,
-0.00046503163,
-0.0064108535,
-0.0036324793,
-0.0064142295,
0.0144759035,
-0.00789963,
0.034056183,
-0.022213489,
-0.0041321144,
-0.0064783716,
-0.0032813847,
0.013807473,
-0.010526088,
0.04480508,
-0.031868592,
-0.0012068879,
-0.00886514,
0.004257023,
0.04310362,
-0.010971708,
-0.011849445,
-0.0014617691,
0.014570429,
-0.022578089,
0.0006574585,
0.00035911246,
-0.0072311996,
0.016433932,
-0.012781196,
-0.035028446,
-0.010431563,
-0.012180285,
-0.009891417,
0.019553272,
-0.0017976722,
-0.029843047,
-0.028843777,
-0.008966418,
-0.021565314,
0.019161666,
0.013409115,
-0.017932836,
-0.027209837,
-0.009000177,
-0.03529852,
-0.010127731,
-0.024468597,
-0.017136121,
-0.03181458,
0.0039295596,
-0.018351449,
-0.021335753,
-0.00519215,
-0.009040687,
0.010998716,
0.022497065,
0.038485378,
-0.007865871,
0.008655834,
0.02436057,
0.0021842138,
0.022159474,
-0.023604365,
0.022213489,
-0.020444512,
0.040916033,
0.0087166,
-0.014678458,
0.005279924,
-0.009351271,
0.0010608798,
0.0072987177,
0.009317513,
-0.014935027,
-0.008021163,
-0.05188099,
-0.0008072645,
0.0025369965,
-0.016339406,
0.005894339,
-0.03170655,
-0.019566776,
0.013895246,
-0.013618422,
0.009709118,
-0.009344519,
0.023752904,
-0.017568236,
-0.0006338271,
0.01242335,
0.018162398,
0.017311668,
-0.020471519,
0.015974807,
0.0019698436,
-0.013699444,
-0.0073122215,
-0.016663494,
0.016190866,
-0.009520067,
-0.0023074346,
-0.006508755,
-0.0035210743,
-0.002749679,
-0.015002545,
0.001430542,
0.0035278262,
-0.0009815459,
-0.0016339406,
-0.023874437,
0.0034079815,
0.0065357625,
-0.01257189,
0.0052495403,
-0.035433553,
0.0070894114,
0.019607287,
-0.009304008,
0.040753987,
-0.0070961635,
0.025211297,
0.012281561,
-0.022996701,
-0.021146702,
0.0051043765,
0.0062082987,
-0.016622983,
0.023428816,
0.006218427,
-0.017568236,
-0.019296704,
-0.01346313,
0.00398695,
-0.017500719,
-0.01609634,
0.036729902,
-0.0014778047,
0.020741593,
-0.016231377,
0.0016044014,
-0.020295972,
0.025062758,
0.006502003,
-0.017514223,
-0.0063602147,
0.008480286,
-0.0374591,
0.0024897337,
0.020295972,
0.03351604,
0.013841232,
0.00526642,
-0.00671131,
-0.013287582,
-0.026170056,
0.0061205253,
-0.0059314743,
0.04364377,
-0.02752042,
-0.0009190916,
0.002749679,
0.02773648,
0.014408385,
0.0062251785,
0.00278175,
0.032516766,
-0.005114504,
-0.021133197,
0.057363465,
0.0048275515,
0.013564407,
-0.013800721,
-0.013591414,
-0.026588669,
-0.037378076,
-0.0010811352,
0.025467867,
0.021268234,
-0.02941093,
0.0021977175,
-0.024266044,
-0.0006148376,
-0.023833927,
0.0032256823,
0.015191596,
-0.027871516,
-0.0139762685,
-0.010971708,
-0.008277732,
0.013179554,
-0.019364221,
0.0038654173,
0.01539415,
0.023941955,
-0.007109667,
0.019269696,
0.0068564736,
0.022145972,
0.0006321392,
-0.005715416,
-0.015475173,
-0.032651804,
0.016663494,
-0.0067855795,
-0.027709471,
-0.029951075,
0.010627366,
0.002138639,
0.014935027,
0.0008912403,
0.0023276901,
0.0017318419,
0.0033927897,
0.0046790116,
0.0010676316,
0.01887809,
-0.01679853,
-0.0023783287,
0.01431386,
-0.033245966,
-0.010039957,
-0.006994886,
-0.0062218024,
0.013071525,
-0.006691054,
-0.01042481,
-0.021106191,
-0.016433932,
-0.020093419,
-0.02514378,
0.0009874537,
0.0019141411,
-0.02344232,
0.014854005,
0.008203462,
-0.011653642,
-0.030518228,
0.012983751,
0.02180838,
-0.005975361,
-0.015880281,
0.016082836,
0.02176787,
-0.015488676,
-0.030977352,
-0.001391719,
0.012713678,
0.01431386,
0.019823344,
-0.033029906,
-0.008358754,
0.01550218,
-0.042671505,
-0.005452095,
-0.039808735,
0.008473535,
0.025859473,
0.020039404,
-0.01045857,
-0.019526266,
-0.024522612,
0.00071695895,
-0.0055905073,
-0.00069754745,
0.032759834,
-0.0020930644,
0.05217807,
0.012335576,
-0.029924069,
-0.0040780995,
0.022780642,
-0.015272618,
-0.007879375,
0.011626635,
0.021686848,
0.0077983527,
-0.022456555,
0.01872955,
-0.0015858338,
-0.00013123851,
0.007967148,
-0.024428086,
-0.0060698865,
0.0053879526,
0.0037067495,
-0.01461094,
0.0037472604,
0.013949261,
0.0041321144,
-0.02269962,
-0.018702542,
-0.018918602,
0.011187767,
0.0020103545,
0.011538861,
0.01405729,
-0.010100723,
0.01212627,
0.007629557,
-0.0004992127,
-0.017487215,
-0.01212627,
-0.0042705266,
0.0075012725,
0.01420583,
-0.0088718925,
-0.029383922,
0.00066885224,
0.0045743585,
-0.03297589,
0.02581896,
-0.029599981,
-0.013382108,
-0.024279546,
0.016069332,
0.020282468,
-0.0033590307,
0.010364044,
0.0058099413,
-0.009337768,
0.029843047,
-0.012308569,
0.008595067,
-0.022145972,
-0.03637881,
0.011559117,
0.003115965,
-0.0011030787,
-0.008352002,
-0.011343058,
-0.0099926945,
0.016271887,
0.20201448,
-0.0014904643,
0.008669337,
0.014813494,
-0.011714408,
-0.01249762,
0.0023952082,
0.009020432,
0.004240143,
0.00008149658,
0.015110575,
0.009263498,
-0.0026889124,
-0.0061880434,
-0.00519215,
-0.0086220745,
-0.031733558,
-0.0181759,
-0.014421889,
-0.008081929,
0.012511123,
-0.00052200013,
0.0002485514,
-0.007028645,
-0.010229008,
0.00013957279,
0.011714408,
-0.017446704,
0.02369889,
0.022740131,
-0.00039772442,
0.009736125,
0.002486358,
0.0036020963,
0.022132467,
-0.002290555,
0.0050874967,
-0.010931198,
-0.01342262,
0.013766962,
-0.0078051044,
-0.0035447057,
-0.03167954,
-0.002180838,
-0.011727912,
0.01565072,
-0.010782657,
0.0037270049,
-0.0315175,
0.012355831,
-0.046371505,
-0.010620614,
0.015083567,
0.012693423,
0.016933566,
-0.009499812,
-0.0006342491,
-0.01220054,
-0.0050166026,
0.018486485,
-0.023563854,
0.015245611,
-0.021592323,
0.016190866,
-0.02618356,
0.028924799,
-0.01624488,
-0.028195603,
-0.000052563977,
-0.0033286475,
0.019418236,
-0.00760255,
-0.016298894,
-0.0011587812,
-0.039781727,
-0.010485577,
0.018378455,
0.008041418,
0.02106568,
0.02881677,
-0.0031666039,
0.006765324,
-0.031760562,
0.016771521,
-0.01598831,
-0.035865672,
-0.0048748143,
0.03297589,
-0.018675536,
0.0088111255,
0.013557656,
0.0028560201,
-0.017176632,
-0.014340866,
-0.015340136,
-0.01728466,
-0.0020441136,
0.009614592,
-0.0038822968,
0.008784118,
-0.014408385,
0.059848137,
-0.0036054722,
-0.0039768224,
-0.017109113,
0.004837679,
0.0030281914,
0.020687578,
-0.018864587,
-0.0009840778,
-0.0013723075,
-0.010093972,
0.009175724,
-0.0144759035,
-0.00391268,
0.027304363,
-0.014111305,
-0.021268234,
0.028438669,
-0.02195692,
0.0064108535,
-0.0038991764,
0.0007473421,
0.022064948,
-0.0027327994,
0.01016149,
-0.024049984,
0.012929737,
-0.009628096,
-0.04334669,
-0.016717508,
0.0031328448,
0.007514776,
-0.008892148,
0.0047465297,
0.0025150531,
-0.009412038,
0.004108483,
0.017325172,
0.0016643237,
0.015475173,
-0.016906558,
-0.0015951176,
-0.0021352633,
0.014624443,
-0.023901444,
0.0012313633,
0.00038211085,
-0.0073189735,
-0.008075178,
0.0011900084,
0.0048410553,
0.018959112,
-0.012585393,
0.014678458,
-0.020485023,
-0.021322249,
-0.039700706,
-0.00032978423,
0.028276624,
-0.026399618,
0.01301751,
0.03535253,
-0.027844507,
-0.011970977,
0.0059922407,
-0.17144223,
0.025981005,
0.015920792,
-0.028843777,
0.025440859,
0.0011950722,
0.020890133,
0.021092687,
-0.001878694,
0.00027703564,
0.020863125,
0.0017622252,
-0.039619684,
-0.046560556,
0.0022686117,
0.01450291,
0.0002970801,
0.0003456088,
0.007224448,
0.00041143905,
0.012322072,
-0.020498527,
0.026561663,
-0.014327363,
0.009445797,
0.017608749,
-0.00496934,
0.0005933162,
-0.0024947976,
-0.00070514326,
-0.018608017,
0.016271887,
0.0068530976,
-0.007440506,
0.024752174,
0.003841786,
0.004189505,
-0.015718238,
-0.014394881,
0.02355035,
0.010283022,
-0.013098531,
-0.005600635,
0.0064446125,
-0.03467735,
0.006171164,
0.011822438,
-0.00027429272,
0.005144887,
-0.017932836,
0.023887942,
-0.022213489,
0.03389414,
0.035244502,
0.004817424,
0.003949815,
-0.014138312,
0.012855466,
0.0037506362,
0.0020204822,
0.002673721,
-0.004702643,
0.024603633,
0.016663494,
-0.015232107,
-0.025008744,
-0.019539768,
-0.030815309,
-0.03346202,
0.0037877713,
-0.023644876,
-0.008108936,
-0.008878644,
-0.033381,
0.027358377,
-0.0016364725,
-0.0037742676,
0.009358023,
0.0077645937,
0.034488298,
0.012457109,
0.027547428,
-0.01624488,
-0.0072109443,
-0.0018111758,
0.014097801,
0.005739047,
-0.013152546,
-0.0025251808,
0.013584663,
0.033840124,
-0.028681733,
0.024833195,
-0.019742323,
0.028357645,
-0.009972439,
0.03197662,
0.003956567,
0.0020019147,
-0.011903459,
0.02165984,
-0.017014587,
-0.0046249973,
0.01673101,
0.038485378,
0.022794146,
-0.0055837557,
0.0032510015,
0.022956189,
-0.008142696,
0.0027041042,
-0.0014457336,
-0.004648628,
0.05482478,
-0.019445242,
0.036405817,
0.020295972,
-0.01887809,
-0.004928829,
-0.026129546,
0.049558364,
0.0068598497,
-0.012639408,
-0.0015157837,
0.01906714,
-0.0471007,
-0.11634737,
-0.0404299,
-0.006127277,
0.020552542,
-0.002488046,
0.026264582,
0.016339406,
0.027601441,
0.00034349886,
0.034137204,
-0.018864587,
-0.0066707986,
0.004176001,
0.013733203,
0.03367808,
0.015029552,
0.0024576627,
-0.0059213466,
-0.00025635818,
0.035136472,
-0.015677728,
-0.004176001,
-0.010505833,
-0.008959666,
-0.015677728,
-0.003835034,
-0.020295972,
0.02677772,
0.012760941,
0.02677772,
0.025562393,
-0.00026184405,
0.013341597,
-0.014367874,
-0.044399973,
0.0056985365,
0.0017554733,
-0.014921524,
0.028870784,
-0.002060993,
0.009769884,
0.005303555,
0.027844507,
0.0060395035,
0.0048106723,
-0.021146702,
-0.028357645,
0.008297987,
-0.0070961635,
-0.0075552873,
-0.0145974355,
0.015407654,
-0.010195249,
-0.010445067,
0.040672965,
0.0058842115,
0.0097428765,
0.034002166,
-0.024671152,
0.000866765,
0.027979543,
-0.0027530547,
-0.0006654763,
0.0005937382,
0.028573705,
0.0012178596,
-0.016487945,
-0.022281008,
0.024860203,
-0.0026855366,
0.0034164211,
0.0077308347,
-0.011565869,
-0.005364321,
-0.024482101,
0.019944878,
-0.026386114,
-0.024833195,
0.017163128,
-0.009000177,
-0.002631522,
-0.023766408,
0.0048275515,
-0.00837901,
-0.0016626358,
-0.006606656,
0.006066511,
0.018229915,
0.032570783,
-0.02773648,
-0.012106014,
0.024063488,
-0.00027576968,
0.001091263,
0.01075565,
0.013841232,
-0.023415314,
-0.0022956189,
0.04124012,
-0.022996701,
-0.01475948,
-0.037702166,
-0.061630618,
0.0138547355,
0.0051043765,
0.0028087574,
-0.005722168,
-0.028276624,
0.010775905,
-0.004773537,
0.029789032,
-0.03683793,
-0.04361676,
-0.0037405086,
-0.020376993,
-0.01783831,
-0.023712393,
-0.009985942,
0.040591944,
-0.01042481,
0.018810572,
0.011214774,
-0.0050166026,
-0.00095622655,
-0.0096416,
0.02095765,
-0.0097428765,
-0.008453279,
-0.021740861,
-0.008507294,
0.0044156904,
-0.003007936,
0.0037270049,
-0.04183428,
-0.0004167139,
0.0013309526,
-0.020349987,
-0.021335753,
0.01182919,
0.010958205,
0.015272618,
0.0075755427,
-0.034002166,
-0.021740861,
0.0049963472,
0.017919332,
0.011896708,
-0.0131660495,
-0.02922188,
0.022267504,
0.006728189,
-0.02941093,
0.04232041,
0.013881743,
0.0030889579,
-0.0120452475,
-0.042995594,
-0.0030366313,
0.010505833,
0.011343058,
0.0070556523,
-0.017595245,
0.014030283,
0.000033284367,
0.015137581,
0.011147256,
0.007744338,
-0.012355831,
-0.011545613,
-0.0022483561,
0.019796338,
-0.0063399593,
-0.04342771,
-0.01773028,
0.016352909,
0.023604365,
0.008703097,
0.0017504095,
-0.012787948,
-0.024347065,
-0.01598831,
0.003801275,
0.02087663,
-0.022226993,
0.00013577488,
0.012916232,
0.022537576,
0.009229738,
-0.002673721,
0.0087503595,
0.013132291,
0.0076498124,
-0.020444512,
0.008669337,
-0.0058099413,
0.0013723075,
0.027547428,
0.04202333,
-0.010154738,
-0.01138357,
0.02529232,
0.032678813,
0.0038282822,
0.0062758173,
0.0047937925,
-0.008601819,
-0.004219888,
0.020187944,
-0.04472406,
-0.02911385,
-0.0054284637,
0.0017174943,
-0.003389414,
-0.026129546,
-0.020404002,
0.015245611,
-0.012639408,
0.018999623,
-0.0111134965,
-0.027682465,
0.01249762,
0.021241227,
0.01405729,
0.0020947524,
0.022024438,
0.002786814,
0.023496335,
0.0011874764,
0.02811458,
-0.015434662,
0.02607553,
-0.03219268,
0.010445067,
-0.011903459,
-0.05107077,
-0.0046722596,
-0.0021082559,
-0.011700905,
0.002033986,
0.018229915,
0.0063635907,
0.083560534,
0.010215504,
0.0023108106,
0.019229185,
0.000338224,
0.02533283,
-0.008102184,
0.026021516,
0.005826821,
-0.026696699,
0.02851969,
-0.024630642,
0.04194231,
-0.028951807,
-0.027641954,
0.013679189,
-0.0059551056,
0.01917517,
0.00043148352,
-0.014705465,
0.031031366,
-0.008554556,
-0.011991234,
0.0059348503,
-0.0033353993,
0.006238682,
0.030761294,
-0.021484293,
0.024792684,
-0.02095765,
-0.013652181,
0.04213136,
-0.03494742,
-0.004857935,
-0.0039396873,
0.004554103,
-0.0055567482,
-0.018675536,
-0.010431563,
0.012295065,
-0.0034349887,
0.035865672,
0.002374953,
-0.0058808355,
-0.0064986274,
-0.0082507245,
-0.027236843,
0.025508378,
-0.017311668
] |
The tricyclic antidepressant, amitriptyline, is an effective drug for the treatment of chronic tension-type headache and for other chronic pain syndromes, but it is also effective in the prophylaxis of an episodic type of headache such as migraine. However, its efficacy in episodic tension-type headache has not yet been clarified. We compared the efficacy of amitriptyline (25 mg/day) in 82 nondepressed patients with either chronic or episodic tension-type headache in an open-label study. Amitriptyline significantly reduced (P < 0.05) frequency and duration of headache | [
-0.017135778,
-0.003957673,
0.019158661,
-0.016966118,
-0.019680696,
0.021168495,
-0.0065515316,
-0.017788323,
0.0150476415,
-0.020711714,
-0.0061665312,
0.017736118,
0.028189857,
0.0078305155,
-0.029051214,
0.010845264,
0.05966853,
0.013481538,
-0.019145612,
-0.00235568,
0.0051811915,
-0.0023328413,
-0.0034128,
-0.000180265,
-0.015191201,
0.010434163,
-0.009285687,
-0.030773927,
-0.01623527,
-0.034088846,
0.0013744186,
0.008835432,
-0.00021370783,
-0.017866626,
-0.010656027,
-0.00766738,
-0.0014135713,
0.017409846,
0.025488328,
0.018780187,
0.04262411,
0.003696656,
0.0037358087,
0.013148741,
-0.012457046,
0.0101796705,
0.018453917,
-0.02443121,
-0.02852918,
0.00641776,
0.003996826,
0.005266022,
-0.007876194,
0.008052381,
0.01267891,
-0.005667336,
0.0075499224,
0.019471882,
-0.0031827784,
-0.02261714,
-0.020529002,
0.0020734554,
-0.008483059,
-0.000034385957,
-0.0077652615,
0.0022839005,
-0.0031289435,
-0.01867578,
0.026532399,
-0.017096626,
0.022682395,
0.024953244,
-0.009996958,
-0.028189857,
0.042702414,
-0.024966294,
0.008535262,
-0.025266465,
0.0024910828,
-0.0008144552,
0.02231697,
-0.004372038,
-0.029494943,
0.009331365,
0.010682128,
0.004052292,
-0.00097473606,
-0.0036444527,
-0.020411545,
-0.00032545583,
0.003468266,
0.013096537,
-0.007569499,
0.02033324,
0.011615265,
0.023856971,
-0.0021615487,
0.028920704,
0.0015367387,
-0.0047994535,
-0.022147309,
-0.0051453016,
-0.001825489,
-0.002094663,
-0.027432907,
0.008574415,
-0.022264767,
-0.0042741564,
0.026075618,
-0.02959935,
-0.01743595,
0.035002407,
-0.020711714,
-0.023295784,
-0.0212468,
0.012776792,
0.04387699,
-0.01774917,
0.013951369,
-0.02595816,
-0.00167051,
0.006564582,
0.016039507,
-0.0043948772,
0.008600516,
0.021638324,
-0.013768657,
-0.021729682,
0.015621879,
0.018310357,
-0.025227312,
0.039831225,
0.022525784,
0.0021827563,
-0.02717189,
0.006339455,
-0.009096449,
-0.014747472,
-0.033331897,
-0.009226958,
-0.0048418688,
0.025618838,
-0.019954765,
-0.009533653,
-0.013240097,
0.032131217,
0.0063231415,
0.03395834,
0.0008899055,
0.0032235624,
-0.009990433,
-0.03836953,
-0.009905603,
0.026675956,
-0.007047464,
-0.013925267,
-0.01245052,
0.00010736371,
-0.047244113,
-0.020124426,
-0.0013368975,
-0.035289526,
0.02413104,
0.00956628,
0.026806466,
0.01731849,
0.0024535616,
-0.023765616,
0.013533741,
-0.011302045,
-0.020685613,
0.008378652,
-0.015373913,
-0.004717886,
-0.0018303831,
0.014747472,
0.026375787,
-0.008000177,
0.007334583,
-0.027250195,
-0.02627138,
0.005334539,
0.0053508524,
0.004381826,
-0.018049339,
0.025135957,
-0.001645224,
0.002947863,
0.00033911844,
-0.04082309,
-0.010297128,
0.014303742,
-0.025135957,
-0.025971211,
-0.6243531,
-0.020972732,
-0.0016109655,
-0.00036848287,
0.024052734,
-0.0033165498,
0.027276296,
0.015922049,
-0.017657813,
0.0037162323,
0.0070344135,
0.020281035,
-0.0029201298,
-0.011295519,
0.010669078,
-0.015021539,
-0.0273285,
-0.02444426,
-0.0024584557,
-0.009605433,
-0.0061436924,
0.011843655,
-0.0077326344,
0.006055599,
0.032209523,
-0.013103063,
0.007132295,
-0.011784926,
-0.017044423,
0.03549834,
-0.014251539,
0.05434378,
0.0076739057,
-0.006009921,
0.044033602,
-0.027746128,
0.014277641,
-0.009324839,
0.011171536,
0.029468842,
-0.01958934,
-0.027380703,
0.002076718,
0.005667336,
0.004920174,
0.017814424,
0.01760561,
-0.003993563,
0.0156088285,
-0.004156699,
0.0016109655,
0.0028075662,
-0.008463482,
0.0028352994,
0.0075172954,
-0.004639581,
0.023387142,
-0.01336408,
0.0030229054,
-0.0034519525,
-0.009977383,
0.014825776,
-0.015504422,
0.0043165716,
-0.010355857,
0.0053997934,
0.011419502,
-0.010107891,
0.009259585,
0.0137556065,
0.012620182,
0.012052469,
-0.030643418,
-0.008711449,
0.008104584,
0.019537138,
-0.01130857,
-0.01626137,
-0.010982298,
-0.0032790285,
-0.0009796302,
-0.0067733964,
-0.006936532,
-0.009018144,
0.039674614,
0.018166797,
-0.014734421,
0.013311877,
0.020320188,
-0.009572806,
0.009814247,
0.0025269727,
-0.023334937,
-0.0425197,
-0.04267631,
0.04296343,
0.00888111,
-0.00858094,
0.019511035,
-0.0045449617,
-0.0096511105,
0.011230265,
0.012032893,
-0.010858315,
-0.0040620803,
-0.0141862845,
-0.014564759,
0.0005208109,
0.05418717,
0.009357466,
0.0064601754,
-0.0159351,
-0.016130863,
-0.013977471,
0.03672512,
-0.018597474,
0.005859836,
-0.017736118,
-0.011328146,
-0.0425197,
-0.00252371,
-0.0074324645,
0.011634842,
0.0047537754,
0.007380261,
-0.0075956006,
-0.0025905957,
0.020894427,
-0.030878333,
-0.026780365,
0.00071045617,
0.015465269,
0.00455475,
0.0024486675,
0.01305086,
0.014238488,
0.04082309,
-0.0133901825,
0.013213996,
-0.032679353,
0.0025808075,
0.015687134,
-0.005572717,
0.011406451,
-0.0044731824,
-0.0333841,
-0.00478314,
-0.011673994,
-0.01563493,
-0.00031668728,
0.012659334,
-0.020307139,
-0.0079610245,
0.018192898,
-0.0010000222,
-0.026297482,
-0.01789273,
-0.0455475,
-0.020816121,
-0.022069003,
0.0028695578,
0.00097636745,
-0.023491548,
0.01697917,
-0.022121208,
-0.021794936,
-0.016496286,
0.03769088,
0.0015514209,
-0.0136903515,
0.0022284342,
-0.017801372,
0.00180265,
0.028816298,
-0.021768834,
0.016013404,
0.006411235,
-0.036333594,
0.010897468,
-0.0056249206,
-0.03082613,
0.0073280577,
0.0017015059,
0.0072106,
0.027093586,
-0.015152048,
0.012045943,
-0.0043296227,
0.009272636,
0.013181368,
0.0045939027,
0.044868857,
-0.041997667,
0.0066233114,
-0.014812726,
-0.009625009,
0.02142951,
0.016874762,
0.012437469,
0.014382048,
0.042102072,
-0.033488505,
0.00160444,
-0.01039501,
0.016052557,
-0.032705456,
-0.008535262,
-0.012920351,
0.0136512,
-0.0024372481,
-0.015530523,
-0.005230132,
-0.026062567,
-0.012032893,
-0.0021419723,
0.03716885,
0.009324839,
0.005269285,
-0.005197505,
-0.032574944,
0.0062905145,
0.002843456,
0.003967461,
0.022330021,
-0.020176629,
0.042128175,
0.031661384,
0.0029087104,
-0.005549878,
-0.0066233114,
-0.013468487,
-0.0005106149,
0.007850092,
0.009429246,
0.040248852,
0.010336281,
0.0040555545,
-0.009833823,
0.019197814,
0.003409537,
0.0043589873,
0.0071257693,
-0.0027994094,
-0.010492891,
-0.0030816342,
0.025227312,
0.025436126,
0.014590861,
0.035420034,
0.012430944,
-0.013468487,
0.014825776,
0.0014364102,
-0.017240185,
-0.013846962,
0.009233483,
0.000812416,
0.030147485,
0.049410556,
0.021742733,
0.011249841,
0.0065189046,
0.0071583968,
0.006479752,
0.016509337,
0.0038141138,
0.011915435,
0.001391548,
-0.022408325,
-0.019680696,
-0.02107714,
-0.021220697,
-0.0055042002,
-0.027250195,
0.012117723,
-0.009207382,
-0.02200375,
0.019706799,
0.0071388204,
-0.00028344835,
-0.023100022,
-0.061443448,
0.0110736545,
0.009820772,
0.014747472,
0.006600472,
0.011445604,
0.009083399,
-0.009350941,
0.026989179,
-0.00021839798,
0.025370872,
-0.019863408,
0.015908998,
0.004659157,
-0.009957806,
0.034715287,
0.012404842,
0.000606865,
-0.019093407,
0.011902384,
0.015687134,
-0.019693747,
-0.0043328856,
-0.02062036,
0.0011558167,
-0.03356681,
-0.02474443,
-0.026858669,
0.0039217835,
0.019772053,
-0.007843567,
0.01580459,
-0.0033442827,
0.021742733,
0.02521426,
-0.0014812726,
0.020124426,
0.03779529,
-0.002145235,
0.009625009,
-0.0136512,
-0.020098325,
-0.0033393886,
0.033018675,
0.008372126,
-0.003993563,
0.002190913,
0.025853753,
0.015060692,
0.020072222,
-0.017044423,
0.027459009,
0.020555103,
0.008398228,
-0.0036640288,
0.0035335203,
0.012698486,
0.018036287,
0.017044423,
-0.0028728205,
-0.028163755,
0.0073280577,
0.0067277183,
0.031034945,
0.023909176,
0.004678733,
0.026114771,
0.02808545,
-0.012013316,
0.02761562,
0.033880033,
0.01580459,
0.0009421089,
0.007889245,
-0.0010114416,
-0.0071127187,
0.022682395,
-0.023400191,
-0.008443906,
-0.013794758,
-0.001305086,
0.029260028,
-0.012665859,
0.004496021,
0.011497808,
0.018010186,
0.0054389457,
-0.008522212,
-0.021533918,
0.016639845,
-0.015034591,
0.0015864951,
0.012254757,
-0.00504742,
0.026049515,
-0.016365778,
-0.0025954896,
0.014473404,
-0.0038597917,
-0.028607484,
-0.014486454,
-0.023896124,
0.02518816,
-0.008215516,
-0.034167152,
0.0028679264,
-0.023674259,
0.01259408,
-0.0018369085,
-0.007119244,
0.0039185206,
-0.0037488595,
0.011328146,
0.00059340626,
-0.01305086,
-0.030591216,
0.040431563,
0.02474443,
0.011563062,
0.0011966007,
-0.01697917,
0.014995438,
0.02184714,
-0.018832391,
0.0035433085,
-0.011582638,
-0.006385133,
-0.022356123,
-0.0024029897,
0.0043198345,
-0.0074455156,
0.0054063187,
-0.0071127187,
0.020307139,
-0.020855274,
0.041527834,
-0.035942066,
-0.0014045988,
-0.011641366,
0.019511035,
0.010662552,
-0.008124161,
-0.013585945,
0.014029674,
-0.0073541594,
0.01199374,
-0.048679706,
0.00880933,
-0.013298826,
0.00648954,
0.020150527,
0.00071127183,
-0.014564759,
0.022408325,
0.014721369,
-0.017957984,
0.012320012,
0.030617317,
0.022839004,
-0.017135778,
0.015700184,
0.014695268,
0.002838562,
-0.019759001,
-0.0079283975,
0.038056307,
-0.023778666,
-0.034402065,
-0.00025530744,
0.026441041,
-0.015125946,
-0.011752299,
-0.00979467,
-0.015256455,
0.034976304,
0.012992131,
-0.01743595,
-0.038761053,
-0.008483059,
-0.031217657,
0.01697917,
0.0031517826,
-0.010290603,
0.0036836052,
0.006450387,
-0.045965128,
-0.013703403,
0.024705278,
-0.022512732,
-0.025840702,
-0.0052562337,
-0.012698486,
0.01686171,
0.0088223815,
-0.012783317,
-0.017840525,
-0.0005591478,
-0.011158485,
-0.033149183,
-0.0123656895,
-0.0048908098,
-0.00596098,
0.02064646,
0.042545803,
0.025279514,
-0.0024372481,
0.009076873,
-0.009324839,
0.020776968,
-0.005977294,
0.009983907,
-0.034897998,
0.011732723,
-0.0043948772,
-0.023739513,
0.03280986,
-0.008319923,
-0.00618937,
0.01941968,
-0.020254934,
-0.033488505,
-0.0205029,
-0.04280682,
-0.0014951391,
0.009135602,
0.0024617184,
0.011713146,
-0.015582726,
0.017344592,
0.023387142,
0.0071453457,
0.009859924,
0.010877891,
0.030251892,
0.005367166,
0.0016191223,
0.0015326603,
0.019706799,
-0.019824255,
-0.002226803,
-0.011824079,
-0.044842754,
0.026036466,
0.028059348,
0.012502723,
-0.009200856,
-0.014943235,
-0.022251716,
0.004792928,
-0.0273024,
0.024874939,
-0.0019201078,
0.0003803102,
-0.027563415,
0.007569499,
-0.0235307,
-0.015739337,
0.014473404,
0.02852918,
-0.010492891,
0.013990521,
-0.016783405,
0.0074911932,
0.004822293,
-0.047479026,
0.026480194,
-0.022995615,
0.014538658,
0.00474725,
0.0077065327,
0.007576024,
-0.009344416,
-0.024039684,
-0.011406451,
0.030277995,
0.029077316,
0.021690529,
0.0011150328,
-0.0019037941,
0.007151871,
-0.031348165,
-0.024013583,
0.008509161,
0.0067603453,
-0.0024339852,
-0.0028858713,
-0.01222213,
-0.02748511,
0.025971211,
0.0010979036,
0.014695268,
0.019393578,
-0.011145434,
-0.030069182,
0.044842754,
-0.015073743,
0.022499682,
-0.024052734,
0.023582904,
-0.016052557,
-0.007419414,
-0.017723067,
-0.0036640288,
0.009501026,
0.008920263,
-0.023439344,
0.009363992,
0.010956197,
0.0029380748,
-0.010284077,
-0.023152225,
-0.014904082,
0.03234003,
-0.0005836181,
-0.013416284,
0.034219354,
-0.014147132,
0.0069952607,
-0.029155621,
-0.021938495,
-0.0094945,
-0.013703403,
-0.018153746,
0.026180025,
0.0062905145,
-0.024653073,
0.005823946,
-0.008861533,
-0.020842222,
-0.013925267,
0.009089923,
0.0013776814,
-0.026049515,
0.0019103196,
-0.012659334,
-0.00043149406,
0.03098274,
-0.007393312,
0.00054650474,
0.009514077,
0.0019266332,
-0.017109677,
0.004998479,
0.018284254,
0.028503077,
-0.020241883,
-0.009442297,
-0.0057391156,
-0.04693089,
-0.0072823795,
-0.032261726,
-0.036438,
-0.013142216,
0.008770178,
0.020320188,
-0.011288994,
-0.027641721,
0.009083399,
-0.0020848748,
0.019223917,
0.014695268,
-0.030565113,
0.027197992,
-0.013481538,
-0.004792928,
0.03218342,
0.00040987856,
-0.031661384,
-0.009344416,
0.006215472,
0.007876194,
-0.016313575,
0.011647892,
-0.029547146,
0.012404842,
-0.041841056,
-0.0007589891,
0.020698663,
0.0026215916,
-0.016626796,
0.009507551,
-0.003934834,
-0.00056526536,
-0.029782062,
-0.013090013,
-0.016196117,
-0.00038255332,
0.0051746657,
-0.011954588,
-0.004407928,
-0.011386875,
-0.021612223,
-0.013005182,
0.010747383,
0.02792884,
0.011223739,
-0.012783317,
-0.0076543293,
-0.025788499,
-0.062435314,
0.008437381,
-0.010381958,
0.010838739,
0.02852918,
0.013598996,
0.008926788,
0.0073867864,
0.015739337,
0.0043622497,
-0.010603824,
-0.0035922492,
-0.0078044143,
0.008763652,
0.009912128,
-0.00084667455,
-0.030147485,
-0.014512556,
0.011282468,
-0.020555103,
-0.032705456,
0.011628316,
0.019497985,
0.013846962,
-0.00071616593,
-0.0068712775,
0.0041599614,
-0.04223258,
0.006114328,
-0.004130597,
0.016391879,
-0.024861887,
0.0127963675,
-0.012548402,
-0.0078044143,
0.011791452,
0.013377131,
-0.005334539,
-0.054813612,
-0.0379258,
-0.025631888,
-0.04995869,
-0.0026574812,
0.0140557755,
-0.010518993,
0.007419414,
-0.007823991,
-0.011732723,
-0.03294037,
0.0053606406,
-0.026375787,
-0.0027357864,
0.018832391,
0.0013360818,
-0.014930183,
0.026349686,
0.019706799,
0.009879501,
0.016300524,
-0.019458832,
-0.011608739,
-0.002985384,
-0.015713235,
0.010832214,
0.0037260205,
-0.0003637927,
-0.006897379,
-0.013873064,
0.0063329297,
-0.03218342,
0.0071061933,
-0.03826512,
-0.004166487,
0.0043785633,
-0.020750867,
-0.002464981,
0.0057358528,
-0.0015718129,
-0.0047309366,
0.031948503,
0.17832695,
0.02931223,
-0.007576024,
0.0022023325,
-0.005745641,
0.008554839,
0.01563493,
0.008411279,
-0.008417805,
0.030930538,
0.026584601,
0.00083117664,
-0.012757216,
0.0018858493,
0.0017243448,
-0.034663085,
-0.019563239,
0.000901325,
0.006329667,
-0.0137556065,
0.009892551,
0.00008681881,
0.021794936,
0.0019788365,
0.024379006,
0.022055954,
0.016626796,
-0.021599174,
0.036672916,
-0.0041762753,
-0.031008843,
-0.008541788,
0.014721369,
0.004978903,
-0.018284254,
-0.010231874,
-0.008104584,
-0.0034486896,
-0.013246623,
-0.0088223815,
0.004587377,
-0.017696965,
-0.026388839,
-0.005080047,
-0.01275069,
0.029834265,
0.02002002,
-0.042284787,
0.008626618,
0.011132384,
-0.02520121,
-0.0050996235,
0.011595689,
0.012019842,
0.0008185336,
-0.03145257,
0.04004004,
0.010434163,
-0.0014559865,
0.0064732265,
0.00972289,
-0.003973987,
-0.023021717,
0.0000738699,
0.0040359786,
0.0015179781,
-0.016900863,
0.0026950026,
0.018989,
0.0006341902,
-0.00022757436,
-0.022839004,
-0.009377043,
0.02111629,
-0.009859924,
-0.0016933491,
0.035002407,
0.005941404,
-0.015856795,
0.009468399,
-0.014329844,
-0.0015530523,
0.020228833,
0.011700096,
0.0050311065,
-0.021873241,
0.020085273,
0.033514608,
-0.0021729681,
0.015530523,
0.0043100463,
-0.01327925,
-0.011373824,
-0.0030685833,
0.025292566,
0.00019280607,
-0.016287472,
-0.018558323,
0.0033475456,
0.0065156417,
-0.012058995,
0.05742378,
0.0075172954,
-0.008939839,
-0.017057473,
-0.012789843,
-0.017344592,
-0.024496464,
-0.0033083928,
0.020241883,
0.006672252,
-0.030721724,
0.015674083,
-0.027981043,
-0.0014559865,
0.02824206,
0.01866273,
-0.039596308,
-0.013638148,
-0.004450343,
0.009044246,
-0.023556802,
-0.0045155976,
0.0072954306,
-0.016313575,
0.0030049605,
-0.008450432,
0.0068712775,
0.013546793,
-0.038787156,
0.017396796,
-0.015073743,
0.006626574,
0.020985782,
-0.0094945,
0.02657155,
0.028581383,
-0.010271027,
0.00038622387,
0.022082055,
0.010884417,
-0.015360862,
0.01192196,
0.009677213,
0.011954588,
0.0003087344,
-0.016992219,
-0.0034486896,
-0.032601047,
-0.017840525,
-0.0062872516,
-0.015008489,
-0.00072146783,
0.0051453016,
0.025657991,
-0.011948062,
-0.03145257,
-0.0066787773,
-0.0033834353,
0.02368731,
-0.04066648,
0.0010244924,
0.014473404,
-0.01623527,
-0.0002630564,
0.016143914,
-0.16130863,
0.014068827,
0.02398748,
-0.021207647,
0.0333841,
-0.004978903,
0.015895948,
-0.004336148,
-0.013305351,
-0.0032300877,
0.006593947,
0.004381826,
-0.026153922,
-0.020463748,
0.011797978,
-0.006479752,
0.014564759,
0.009664162,
-0.011628316,
0.013103063,
-0.0106429765,
-0.011504333,
0.011811028,
-0.008019754,
0.009350941,
0.027511213,
-0.0026607441,
0.020855274,
0.016078658,
0.0106234,
-0.014277641,
0.011830605,
0.038056307,
0.012724589,
0.022577988,
0.0031958292,
0.004130597,
0.021064088,
-0.0033508083,
0.015034591,
-0.008385178,
-0.011027977,
0.020868326,
0.008522212,
-0.0055564037,
0.019067306,
0.02263019,
-0.015882896,
-0.009905603,
0.014016624,
0.0076282276,
-0.030878333,
0.021481715,
0.00481903,
0.0197329,
0.01884544,
0.009631534,
0.0058467854,
0.007713058,
-0.041788854,
-0.007608651,
-0.018297305,
0.019719848,
0.011621791,
0.016130863,
-0.03568105,
0.0048679705,
-0.009625009,
0.0077195833,
0.039570205,
-0.024052734,
-0.0348719,
-0.009318314,
-0.03505461,
0.005050683,
0.02852918,
-0.0026444304,
0.022434428,
0.0070344135,
-0.012411367,
-0.017866626,
0.0017145567,
-0.03688173,
-0.0030294308,
-0.005530302,
-0.008783229,
0.008045855,
0.0115695875,
-0.012117723,
-0.020816121,
0.025175108,
-0.030408503,
0.017997136,
-0.008894161,
0.021207647,
-0.009057296,
0.0006590684,
0.014434251,
0.0039511477,
-0.0037945374,
0.018649679,
0.021011883,
-0.002186019,
0.029834265,
0.027824434,
0.017957984,
0.00995128,
0.0005799476,
0.006306828,
-0.0029054477,
-0.02231697,
0.0019380527,
0.032392234,
0.0073215324,
0.026936974,
0.018101543,
0.002505765,
-0.0010530412,
-0.0057260646,
0.0022887946,
0.07616482,
-0.0016917177,
-0.010460264,
-0.030695623,
-0.001998413,
-0.03461088,
-0.12372215,
-0.0105124675,
0.0059870817,
-0.0048581827,
-0.00097310473,
0.0092530595,
0.004189326,
0.034088846,
0.017396796,
0.021886291,
-0.027720027,
0.006567845,
0.016352728,
-0.017840525,
0.0273024,
-0.031139351,
-0.011132384,
-0.016313575,
-0.04369428,
0.044686142,
-0.026493246,
0.0066461503,
0.0019298958,
-0.031661384,
0.00698221,
-0.010714755,
-0.013625097,
0.016196117,
0.0006586606,
0.013912217,
0.012280859,
-0.024039684,
0.025553584,
0.03581156,
0.018767137,
-0.0016191223,
0.01053857,
0.006786447,
0.02458782,
-0.029364435,
0.0027553628,
0.0004527017,
0.03586376,
-0.004440555,
0.02291731,
-0.019980866,
-0.014368997,
0.01426459,
0.016183065,
0.0062415735,
-0.032705456,
-0.005566192,
-0.020241883,
0.005050683,
0.0273024,
-0.0029543883,
-0.0004808426,
0.012881199,
-0.032888167,
-0.0006631468,
0.007576024,
-0.009259585,
-0.006714667,
0.014160182,
0.027224094,
0.009846874,
-0.0066167857,
-0.009807721,
-0.0058043697,
-0.017383745,
-0.009416196,
0.022643242,
-0.023817819,
0.008633143,
-0.027276296,
0.014538658,
-0.009168229,
-0.0145517085,
0.025488328,
0.012352639,
-0.04019665,
-0.009990433,
-0.015138998,
0.00334102,
0.023021717,
0.020176629,
0.0029054477,
-0.0034486896,
0.014094928,
-0.023256632,
0.018480018,
0.017344592,
0.003938097,
0.03688173,
-0.0014951391,
0.0035628846,
-0.0025954896,
0.002701528,
0.020124426,
0.010532044,
-0.02550138,
-0.023347989,
-0.042728513,
0.019706799,
0.035733253,
0.0071127187,
0.022082055,
-0.0077000074,
0.03870885,
0.010714755,
-0.003628139,
-0.023334937,
-0.013533741,
-0.016365778,
0.013729504,
0.018271204,
-0.030643418,
0.016665949,
0.024196293,
-0.00242746,
0.020254934,
0.004202377,
0.0036542406,
-0.00451886,
0.0051094117,
0.018649679,
-0.04027495,
-0.0068451758,
-0.004522123,
0.0046265298,
-0.010460264,
0.0074716173,
0.004385089,
-0.02871189,
0.020985782,
0.0016802982,
-0.030460706,
0.0012528825,
-0.018754086,
0.035654947,
0.009912128,
0.014943235,
-0.023452396,
0.00096739497,
0.05225564,
-0.023791717,
-0.015295608,
-0.018727984,
-0.036699016,
0.000009386678,
0.0058467854,
-0.018466966,
0.026088668,
0.009142127,
-0.0062219976,
0.011804502,
-0.036359694,
0.014786624,
0.0076543293,
-0.0013613678,
-0.028816298,
-0.0053051743,
0.004453606,
-0.010597298,
-0.007921872,
-0.007530346,
-0.010564671,
0.0007165738,
-0.0040653427,
-0.014786624,
0.017592559,
-0.0022431165,
0.006903905,
-0.022042902,
0.0034519525,
0.00073329516,
-0.0019298958,
0.0071779727,
0.00071738946,
0.0007035229,
-0.005080047,
0.004404665,
-0.003820639,
-0.00020432752,
-0.039048173,
0.0070278877,
0.0065482687,
-0.0022170148,
-0.029103417,
0.018245101,
-0.01230696,
-0.02627138,
0.009044246,
-0.004186063,
-0.0038467408,
0.017187983,
0.013716454,
0.03385393,
-0.015034591,
-0.0159351,
0.017971033,
0.03080003,
0.013820861,
-0.0022007013,
0.005709751,
-0.017566457,
-0.001020414,
0.0022186462,
-0.04158004,
-0.01820595,
-0.034114946,
0.0027129475,
0.021051036,
0.019954765,
0.00108159,
-0.0015848638,
-0.01031018,
-0.010225348,
0.010753908,
0.0064960653,
0.0075238207,
0.009840348,
-0.007771787,
0.013794758,
0.014603912,
-0.007934922,
0.028946808,
-0.019236967,
-0.003249664,
-0.006045811,
0.0149823865,
0.031165453,
0.009820772,
0.007230176,
-0.021925444,
0.0042969957,
0.0039805123,
-0.033749525,
-0.02672816,
0.035289526,
-0.0054650474,
0.06541091,
-0.0059838193,
-0.016065609,
0.013677301,
0.017696965,
0.0077326344,
0.0037129696,
0.031687487,
0.004440555,
-0.018506119,
0.0027765704,
-0.012013316,
0.02216036,
-0.038212918,
-0.023870023,
0.006714667,
0.009377043,
0.022786802,
-0.000112461705,
0.0013882852,
0.038212918,
0.0008670665,
0.013324928,
-0.035759356,
-0.023713412,
-0.018623577,
0.023113072,
-0.008391703,
-0.02034629,
-0.055022426,
-0.014460352,
-0.0032007233,
-0.005233395,
-0.012946453,
0.007223651,
-0.029990876,
-0.009024669,
-0.022016801,
0.0105124675,
0.0096184835,
-0.012776792,
0.02518816,
-0.0034780542,
-0.015152048,
-0.011334672,
-0.036751222,
0.00956628,
0.00459064,
-0.02808545
] |
The transcription factor Kruppel-like factor 2 (KLF2) was proposed to regulate genes involved in cell cycle entry and T cell trafficking; however, the physiological role of its expression in postactivated T cells is not well defined. Previous studies suggested that the cytokines IL-2 and IL-15 differentially regulate KLF2 re-expression in postactivation T cells and that these cytokines also influence effector versus memory T cell differentiation. Using conditional and inducible KLF2-knockout model systems, we tested the specific role of KLF2 expression in activated CD8(+) T cells cultured with these cytokines | [
-0.018587232,
-0.009968205,
0.003199388,
-0.02518904,
-0.018600332,
0.009064387,
-0.032511283,
0.013413196,
-0.009404956,
-0.006140074,
0.015155341,
-0.011978875,
0.013622778,
0.011919931,
-0.0070930137,
-0.005776582,
0.029288972,
-0.01203782,
-0.007368089,
0.0071192114,
-0.024219727,
0.01850864,
-0.00925432,
-0.03670291,
-0.017342843,
0.007931339,
0.012456982,
-0.043907262,
-0.015495909,
-0.023918454,
0.0074990774,
0.011356681,
-0.011729998,
0.020774737,
-0.014120533,
-0.018364552,
0.011264989,
-0.01916358,
0.022150112,
0.010230182,
0.035104852,
0.020630648,
-0.0014998155,
-0.00958179,
0.021272492,
0.0013057891,
0.03599557,
-0.010053348,
-0.005537528,
0.034921467,
-0.0035399573,
0.00037147448,
-0.0025902926,
-0.00033606673,
-0.021089109,
-0.01816807,
0.01626874,
0.007656263,
-0.0014809859,
-0.0211939,
-0.011664503,
-0.007754504,
-0.0021531193,
0.009057838,
0.018115675,
0.013098825,
0.008815509,
0.03196113,
-0.0011731635,
0.0047974447,
0.032144517,
0.027717113,
-0.009634186,
0.009064387,
0.009483549,
-0.018849209,
-0.010203985,
-0.0032403218,
-0.016321136,
0.0023070306,
0.014788574,
-0.015875775,
-0.011075056,
0.018940901,
0.017591722,
0.004411029,
0.019202877,
0.021927433,
0.01103576,
-0.012561773,
0.016098456,
0.02027698,
0.047679722,
0.03644093,
-0.010315324,
0.004031163,
0.0022562726,
0.019661335,
-0.00046255224,
-0.04168046,
-0.024193529,
-0.0025247985,
-0.0022644594,
-0.013465592,
-0.037541233,
-0.0015710403,
0.0013925688,
-0.007682461,
0.01960894,
-0.008415995,
-0.032694668,
0.04757493,
0.010839278,
-0.035785988,
0.028896008,
-0.0020630648,
-0.012980935,
-0.011009562,
-0.028686427,
-0.005606297,
0.009372209,
0.014513498,
-0.003909999,
-0.025333127,
0.02140348,
0.0045158197,
0.011631756,
-0.010773784,
-0.030022506,
-0.00040544957,
0.021809543,
0.01225395,
-0.0011003013,
0.0045878636,
-0.013013682,
0.0004920246,
-0.012306346,
-0.00105773,
0.012876145,
-0.012018172,
0.0065232147,
0.025699895,
-0.0074073854,
0.0056652417,
-0.0037953844,
0.014631387,
0.01772271,
0.017369041,
-0.0058519,
-0.0039525703,
-0.009346011,
-0.027271753,
0.03222311,
-0.0038445052,
0.02607976,
0.005917394,
0.0048727626,
0.032327898,
-0.01326911,
-0.034083143,
-0.006664027,
-0.016962979,
0.02708837,
0.01750003,
0.020054301,
0.018665826,
0.024651987,
0.008632125,
-0.003988592,
-0.016701002,
-0.0068703336,
0.005927218,
-0.023826763,
0.016203247,
-0.0029963562,
0.0029308621,
-0.006087679,
0.012168808,
-0.006264513,
-0.018037083,
0.000388462,
0.02619765,
0.02931517,
-0.0027998737,
-0.0141991265,
-0.010131941,
0.010105743,
-0.023250414,
-0.0143825095,
-0.003631649,
-0.01013849,
0.015286328,
0.010446313,
-0.022215607,
-0.62790525,
-0.016779594,
0.03623135,
-0.009725877,
-0.011166749,
0.035366826,
-0.014618289,
-0.0070406185,
-0.034476105,
0.027009776,
0.0013671898,
0.01883611,
-0.004610786,
-0.013910952,
-0.03575979,
-0.054071948,
-0.013177418,
-0.008677972,
0.026472725,
-0.0041556023,
0.0007662813,
-0.0046533574,
0.0035628804,
0.039506055,
-0.023787465,
0.025791585,
0.025385523,
-0.011395978,
0.0016586387,
0.043226123,
-0.02061755,
0.020656846,
0.0023037558,
-0.00045886822,
0.048544243,
0.0094377035,
-0.016962979,
-0.0030798612,
0.008553533,
0.045610107,
-0.009011991,
-0.0036283745,
0.0301011,
0.01527323,
-0.017133262,
0.01649142,
0.0034613644,
0.026459627,
0.021010514,
-0.0013409922,
0.0044732485,
-0.005007026,
-0.024992557,
-0.010786883,
0.021351084,
0.0066181812,
0.015849577,
-0.01047251,
-0.009090585,
-0.0013025143,
-0.009051288,
0.017251153,
-0.022634769,
-0.00083586876,
-0.00724365,
0.006667302,
0.006215392,
-0.004846565,
0.0001740711,
0.008154019,
0.011991974,
0.020119796,
0.008953047,
0.00008764956,
0.010433214,
0.030625053,
0.0016627321,
-0.010767234,
0.0077610537,
0.01270586,
-0.00880241,
-0.010734487,
-0.022791956,
0.0005133102,
0.00033013133,
-0.008147469,
-0.024442406,
0.0234076,
-0.016543815,
0.030808436,
0.018534837,
-0.0031453553,
-0.019779226,
-0.03308763,
-0.02463889,
0.035288233,
-0.0077741523,
0.011278088,
0.0024543924,
-0.0312014,
0.015247032,
-0.000100390214,
0.0178406,
0.0068834326,
0.006195744,
0.0057340106,
-0.03955845,
0.0033467498,
0.037488837,
-0.039951414,
0.0037888351,
0.01839075,
-0.010675542,
-0.008776213,
-0.011559713,
-0.02140348,
0.029629542,
0.013609679,
-0.016648605,
-0.0046566324,
0.023486193,
-0.0009807745,
0.008448742,
-0.0007196167,
0.015692392,
0.03044167,
-0.004368458,
0.008003382,
-0.0047352253,
-0.010321874,
0.0067131477,
0.0037953844,
0.018809913,
-0.027009776,
0.0132363625,
-0.0052035083,
0.04513855,
0.01125844,
0.011782393,
-0.03966324,
-0.026367934,
-0.0023283162,
0.015482811,
-0.028110078,
-0.0014588817,
-0.0032861677,
-0.0038969005,
0.015797183,
0.007872393,
0.0007208447,
0.0028735546,
-0.02051276,
-0.015312526,
0.0022922943,
0.0075580217,
-0.009876514,
-0.01225395,
-0.010020601,
0.0052755517,
-0.02921038,
-0.0099878535,
0.0043291617,
-0.022490682,
0.016635507,
-0.0014989967,
0.0011878997,
-0.00025031035,
0.013321505,
0.017971588,
-0.041759055,
-0.006483918,
-0.022385892,
-0.018561035,
0.013557283,
-0.0024887768,
-0.0066378294,
0.005007026,
-0.009745525,
-0.009129881,
-0.008226062,
0.0026083034,
-0.008743466,
-0.006431523,
-0.020997416,
0.03620515,
0.007839646,
-0.0061498983,
0.012142611,
0.0011952678,
0.03277326,
-0.0075187255,
-0.015639996,
-0.02162616,
0.023211118,
0.009503198,
-0.028031485,
0.011952678,
0.0018354729,
0.0031142456,
0.028398253,
-0.0070930137,
-0.021534467,
0.0067786416,
-0.03376877,
-0.0057995045,
-0.032065924,
-0.010564202,
-0.010944068,
0.015613799,
-0.0014416894,
0.0066116317,
0.013858557,
-0.005449111,
0.010983365,
0.00601891,
-0.0006103234,
-0.0032566953,
-0.009765174,
0.001539112,
-0.009712779,
0.0060254596,
-0.014107434,
0.007833097,
0.0019762851,
0.00014418941,
0.014867166,
0.0105904,
0.014592091,
0.00039235075,
-0.0023905355,
-0.009097134,
-0.013884754,
-0.00048793122,
0.00090791227,
0.009634186,
0.008998892,
0.009463901,
-0.013701371,
0.037384044,
-0.0018993296,
0.017107066,
0.0027884124,
0.007512176,
0.009948557,
-0.008939948,
-0.008114722,
0.021652358,
-0.00044863476,
-0.025175942,
-0.01047906,
-0.006107327,
0.015928172,
-0.0022922943,
-0.01760482,
-0.0030683996,
0.012404587,
0.0006733615,
-0.0017028472,
0.03020589,
0.023931554,
0.013924051,
-0.011494218,
0.007996833,
-0.028241066,
-0.012227753,
0.00197956,
-0.007112662,
-0.016504519,
-0.018351454,
-0.006942377,
-0.039375067,
-0.012882695,
0.037881803,
-0.009896162,
0.012064017,
0.016059158,
0.020224586,
0.0038084832,
-0.0039984165,
0.0009398407,
0.007302595,
-0.023132525,
0.024547197,
0.025437918,
0.0044339523,
-0.010027151,
-0.025595104,
-0.020054301,
0.011120902,
-0.004499446,
0.004322612,
-0.0017192208,
0.012437334,
-0.007957536,
-0.014513498,
-0.0023315907,
0.024468604,
-0.016517619,
0.028031485,
-0.008350501,
-0.0015571228,
0.0038379556,
-0.0023037558,
0.005219882,
0.035262037,
0.012620717,
-0.011245341,
-0.017369041,
0.0023152174,
-0.0062939855,
0.011454922,
-0.0029292246,
0.00457149,
-0.018705122,
0.011769294,
-0.007977184,
0.020525858,
0.00446015,
0.015338724,
-0.004558391,
-0.016111555,
-0.007734856,
0.0022104266,
-0.008710719,
0.018888505,
0.02285745,
0.01426462,
0.016674804,
-0.016190147,
-0.008317754,
-0.010708289,
-0.009457352,
0.019674435,
-0.022372793,
-0.005308299,
-0.009077486,
-0.010505257,
-0.006624731,
-0.0034973861,
-0.0004322612,
-0.0042538433,
-0.006605082,
-0.00088498933,
0.0030995095,
0.010616598,
0.010754135,
0.023656478,
0.038484346,
0.015862677,
0.0057667578,
0.0053312215,
0.051766556,
-0.003612001,
-0.02397085,
0.0065232147,
0.021809543,
0.015155341,
-0.00040831493,
0.006844136,
-0.020198388,
-0.0029275874,
0.022254903,
-0.008075425,
0.014552794,
0.027009776,
0.025686795,
0.011978875,
-0.012122963,
0.0071192114,
-0.016897485,
0.00713231,
0.024206629,
0.006654203,
-0.008108173,
0.026210748,
-0.027952893,
-0.022936042,
-0.0071978043,
-0.0018845934,
-0.003733165,
0.004528919,
-0.02129869,
0.0058126035,
0.005472034,
0.00061973813,
-0.025830882,
0.020041201,
-0.006199019,
-0.01326256,
-0.0010208896,
0.015875775,
-0.011939579,
-0.015404218,
-0.023053931,
0.017028471,
-0.028843611,
-0.036257546,
0.009463901,
0.013452493,
0.027848102,
0.0075187255,
-0.011284637,
-0.01359658,
0.0042734914,
-0.01939936,
-0.0062350407,
-0.01973993,
-0.029917715,
0.0013090638,
0.012122963,
0.003227223,
-0.016360432,
-0.0034351668,
-0.007564571,
0.00009240812,
0.0028866534,
0.019451754,
-0.016583113,
-0.004001691,
0.014238423,
0.0334282,
0.01715946,
0.004080284,
-0.0063136336,
-0.008651773,
-0.011225693,
-0.01628184,
-0.009725877,
-0.03020589,
-0.010793432,
0.009516296,
0.01805018,
-0.014696881,
-0.009103683,
0.008769663,
-0.014421806,
-0.0037200663,
-0.024691286,
0.023787465,
0.040606357,
-0.010171237,
0.008907201,
0.012116413,
-0.024245925,
-0.0048236423,
-0.016897485,
0.010426665,
-0.013531086,
-0.011625207,
0.002184229,
0.0030962348,
-0.023774367,
-0.010321874,
0.009883063,
-0.021351084,
0.00969313,
0.0052133324,
-0.0042833155,
-0.014657585,
-0.0039558453,
-0.0000029165353,
0.025346225,
0.016294938,
-0.011206045,
-0.015744787,
0.003019279,
-0.0028833789,
-0.020604452,
0.02955095,
-0.032825656,
-0.023329007,
0.0139895445,
-0.0016815616,
-0.0056521427,
-0.013465592,
0.0018911428,
-0.028581636,
-0.012633816,
0.00034384415,
-0.06591329,
0.006330007,
-0.01705467,
0.0312014,
0.019045692,
0.025988068,
0.003533408,
0.022150112,
0.0002625905,
-0.0055997474,
0.009974755,
-0.00824571,
0.032956645,
-0.026852591,
-0.009162628,
0.00075441046,
-0.007289496,
0.017762007,
-0.020394871,
0.0080950735,
0.016137753,
-0.024259023,
-0.006054932,
0.001743781,
-0.014814771,
-0.02184884,
0.026957382,
-0.013413196,
-0.0019680983,
-0.019975707,
0.011684151,
0.018351454,
0.0031928385,
0.0018043631,
0.016779594,
0.016085356,
-0.021717852,
0.023997048,
-0.025320029,
0.0057995045,
-0.031463377,
0.0012108226,
0.0034908368,
0.00802303,
0.025922574,
-0.007453231,
0.008501138,
-0.00902509,
-0.0074204844,
-0.0047548735,
0.00006590346,
-0.023748169,
-0.017460734,
-0.021914333,
-0.00082113256,
-0.030965623,
-0.020041201,
-0.006664027,
-0.0222942,
-0.0138192605,
0.007302595,
-0.018980198,
0.021141503,
0.00091282435,
-0.017683413,
0.047653526,
-0.0068834326,
0.027297951,
-0.015378021,
0.021796444,
0.016648605,
0.010027151,
-0.0124766305,
-0.028293462,
-0.017762007,
-0.007833097,
0.04034438,
0.033742573,
-0.0073091444,
-0.0019877467,
0.0062022936,
0.0062710624,
-0.007643164,
-0.012116413,
-0.0052002333,
-0.008619026,
0.004728676,
-0.009201924,
-0.007669362,
-0.027586125,
-0.0053115734,
-0.007924789,
0.02084023,
-0.000029267687,
-0.004528919,
-0.013662075,
0.019307667,
-0.015784085,
-0.0028457197,
0.011441823,
-0.008763114,
-0.002012307,
-0.031594366,
0.0019369887,
0.0008825333,
-0.011192946,
0.014395609,
-0.004502721,
0.014343213,
0.021429677,
-0.015548305,
-0.0088548055,
0.0071585076,
-0.008874454,
0.034816675,
-0.021809543,
0.01594127,
-0.003282893,
0.0024724032,
0.0057241865,
-0.019111186,
-0.0048956857,
0.002049966,
-0.024691286,
0.00913643,
0.043540493,
0.005088893,
-0.022988437,
0.015286328,
-0.026420329,
-0.017185658,
-0.023329007,
-0.018076379,
0.020119796,
-0.04490277,
0.0059337677,
-0.0059730643,
0.030913226,
0.004188349,
0.0041556023,
0.012673113,
0.0027556652,
0.03913929,
-0.032930445,
0.023433797,
0.02385296,
-0.017526228,
-0.014408708,
0.0030913227,
-0.010819629,
-0.02173095,
0.020447265,
-0.018495541,
-0.03434512,
-0.0049349824,
-0.0051642116,
0.025346225,
0.00935911,
-0.005540803,
0.013871656,
0.017185658,
-0.000247445,
-0.0046173357,
-0.0039951415,
0.008953047,
-0.009732427,
-0.018115675,
0.027350346,
-0.012587971,
-0.005763483,
0.009784822,
-0.00024887768,
0.007335342,
-0.005773307,
-0.0058224276,
0.0010544554,
0.009680032,
-0.013963347,
0.020525858,
-0.01047251,
-0.0030945973,
-0.008389797,
0.012791002,
0.01404194,
-0.0035203092,
-0.012797552,
0.0039558453,
-0.0076104174,
0.030598855,
-0.010930969,
-0.0057831313,
0.004469974,
-0.045426723,
-0.027717113,
0.010983365,
-0.020001905,
0.03222311,
-0.018023983,
-0.0071061123,
-0.024717482,
-0.004103207,
-0.040711146,
-0.024730582,
0.010066447,
-0.0045092707,
-0.004090108,
0.013406647,
-0.019661335,
-0.007204354,
-0.01192648,
0.03555021,
0.005059421,
-0.026459627,
0.01960894,
0.0028948402,
0.02183574,
-0.0032616074,
-0.019569645,
-0.0222942,
0.022346595,
-0.012299797,
0.0035858033,
0.026629912,
-0.0211939,
0.020041201,
-0.009156078,
0.009241221,
0.009680032,
0.032118317,
0.029236577,
-0.024363814,
0.0041163056,
0.0021678554,
-0.0016741935,
0.00029677025,
0.0100075025,
0.00031068776,
0.006516665,
0.004447051,
0.014303917,
-0.014212225,
0.009404956,
-0.03321862,
0.030336877,
0.026656108,
-0.006533039,
0.00824571,
0.019792324,
-0.010865475,
-0.00008785423,
-0.010898222,
-0.010243281,
-0.008573181,
0.013976446,
0.020303179,
-0.013858557,
0.02719316,
-0.011101254,
-0.022936042,
-0.011559713,
-0.0060614813,
-0.011939579,
-0.031279992,
-0.0064282482,
-0.00024457963,
-0.026512021,
-0.015757887,
0.0028522692,
-0.01193303,
-0.018875407,
-0.00011778709,
-0.008088524,
0.004568215,
-0.01683199,
-0.00270327,
0.011775844,
0.0155221075,
-0.010786883,
-0.0075973184,
-0.007682461,
0.022045322,
0.1950153,
-0.03644093,
-0.0024167332,
0.003376222,
-0.0066804006,
-0.00009824119,
0.022058422,
-0.0019549995,
-0.024796076,
-0.009830668,
0.022110816,
0.010066447,
-0.0027998737,
-0.0020647023,
0.0063136336,
-0.010426665,
-0.017526228,
0.002939049,
-0.015862677,
-0.001910791,
0.023708872,
-0.005308299,
0.023669576,
-0.005069245,
0.06051657,
0.0031977505,
-0.01692368,
0.004630435,
0.013098825,
-0.0033451123,
-0.044509806,
0.017644117,
0.0011174935,
0.0009635823,
0.00105773,
0.015312526,
-0.017382141,
-0.019517248,
0.022791956,
-0.0233945,
0.009090585,
-0.025451016,
-0.026053563,
-0.0056423186,
0.01828596,
0.012162259,
-0.008887553,
-0.0007617785,
-0.018233564,
-0.002749116,
-0.035785988,
-0.009241221,
0.011160199,
0.026682306,
0.009463901,
-0.001928802,
0.014526596,
0.019556545,
-0.0022038773,
0.02596187,
-0.0072501996,
0.0019271646,
-0.026904985,
0.00023598352,
-0.011762745,
0.014159829,
-0.02241209,
-0.004600962,
0.019884016,
-0.0412351,
0.0023168547,
0.018744418,
-0.004702478,
-0.00025972514,
-0.009994403,
-0.02128559,
0.015639996,
-0.008409445,
0.010839278,
0.022215607,
0.02275266,
0.0065788846,
-0.022569275,
-0.003399145,
0.009791371,
-0.009457352,
0.026014267,
0.012299797,
-0.023119425,
-0.02318492,
0.0068834326,
-0.012188456,
-0.013144671,
-0.0012787727,
-0.0010421752,
-0.014801672,
-0.008966146,
0.0029865322,
-0.003765912,
-0.0211808,
-0.039741833,
0.08000762,
0.011998524,
0.012129512,
-0.0040278886,
0.009876514,
0.00006339626,
-0.005940317,
-0.00085060496,
-0.02051276,
0.03290425,
-0.019032592,
0.020984318,
-0.00036697177,
-0.020709243,
-0.001683199,
-0.0044339523,
0.0016193422,
0.03141098,
-0.003946021,
-0.029629542,
-0.0055211545,
0.009830668,
0.032720864,
0.0014506949,
0.012515927,
-0.041523274,
0.009594889,
-0.012129512,
-0.031149006,
0.0064249737,
-0.0038281316,
-0.007715208,
0.035104852,
0.031253796,
-0.02941996,
-0.0053737927,
-0.009719328,
-0.02184884,
0.023067031,
-0.006064756,
-0.011795492,
-0.0060451077,
-0.009994403,
0.013183967,
-0.007564571,
0.014317015,
0.020552056,
-0.029498553,
-0.015993666,
-0.0018338355,
-0.030808436,
0.0040639103,
-0.022765758,
0.028267264,
-0.020918824,
-0.0004969367,
0.0008375061,
0.009005442,
0.004918609,
-0.03290425,
0.020696143,
-0.0041948985,
-0.018744418,
-0.006896531,
-0.022137014,
-0.16326375,
-0.012312896,
-0.0040540863,
-0.009869965,
0.0367553,
0.030284483,
0.00023168547,
0.005082344,
-0.010747585,
0.027821904,
0.03722686,
0.009974755,
-0.05328602,
-0.020800933,
0.0012591245,
-0.001878044,
-0.021901235,
0.0367553,
0.023813663,
0.012673113,
0.036309943,
-0.018299058,
0.010786883,
0.000304957,
0.0047417744,
0.0075383736,
0.015928172,
-0.018416947,
-0.007793801,
-0.02587018,
-0.013308406,
0.015613799,
0.029131787,
-0.003199388,
0.013105374,
-0.0013827446,
-0.0063824025,
-0.015692392,
-0.018259762,
0.033742573,
0.038274765,
0.011448373,
-0.000855517,
0.022084618,
-0.009516296,
0.059416268,
-0.0039525703,
-0.0015603974,
0.006605082,
-0.0039263726,
0.03358539,
-0.009201924,
0.008763114,
0.013052979,
0.01852174,
-0.0004952993,
0.0007687373,
-0.00055015064,
-0.0063038096,
0.01460519,
-0.0059206686,
-0.0023070306,
0.012784453,
-0.008376698,
-0.006228491,
-0.034056943,
-0.014094335,
0.03020589,
-0.015129142,
0.008448742,
-0.016255641,
-0.0013229813,
0.035183445,
-0.010131941,
0.022922944,
0.01248318,
-0.027559927,
0.0053312215,
-0.0046533574,
0.0023381403,
-0.025385523,
0.024219727,
-0.032406494,
-0.00457149,
-0.02652512,
0.017775105,
0.004040987,
0.034764282,
-0.02051276,
-0.009837218,
0.016177049,
-0.014998155,
-0.011690701,
-0.007394287,
0.033690177,
0.030598855,
-0.0081016235,
0.0035072104,
-0.010118842,
-0.0006790922,
0.023302808,
-0.023106327,
-0.014814771,
0.000043696862,
0.026551317,
-0.0013221626,
-0.02955095,
0.01928147,
0.036938686,
-0.00618592,
-0.0012861409,
0.0041948985,
0.004918609,
-0.0071585076,
0.0050332234,
0.029393762,
-0.0059239436,
-0.0013172505,
0.014081237,
-0.027821904,
0.079221696,
-0.012122963,
-0.0028915657,
0.004767972,
-0.014251522,
-0.025162842,
-0.13360801,
-0.012424235,
0.018980198,
0.00457149,
-0.00824571,
0.008546983,
-0.010780333,
0.02907939,
-0.015928172,
0.012005073,
-0.0423616,
0.025359325,
0.008736916,
-0.013452493,
0.008645224,
0.022464484,
0.0025264358,
-0.015626898,
-0.023198018,
0.036074165,
-0.00546221,
-0.013570382,
-0.010433214,
-0.024324518,
-0.0029783454,
0.008409445,
-0.048884813,
0.013753766,
0.010518356,
0.007289496,
-0.0030765864,
-0.023486193,
0.047836907,
-0.0038969005,
-0.0027965992,
-0.011808591,
-0.01683199,
-0.021613061,
0.04770592,
-0.019071888,
-0.019674435,
0.0044536004,
0.0064806435,
-0.0018714946,
0.008350501,
-0.002305393,
-0.02852924,
-0.0017486931,
0.025988068,
-0.028555438,
-0.040763542,
-0.04849185,
-0.033690177,
-0.01615085,
0.029839123,
-0.0060352837,
0.015679292,
0.041287497,
-0.01973993,
0.0025952046,
0.02719316,
0.017460734,
-0.005180585,
-0.0016692815,
0.037488837,
-0.007374638,
-0.009503198,
-0.03824857,
0.028241066,
-0.0130464295,
-0.0072698477,
-0.0049415315,
-0.014657585,
0.00657561,
-0.015901973,
0.021141503,
-0.016216345,
-0.001956637,
0.014474201,
-0.030860832,
-0.022110816,
-0.008016481,
0.004483073,
-0.012430784,
0.05250009,
0.0007036525,
0.0022055146,
-0.02576539,
0.0054818583,
0.011395978,
-0.012574872,
0.047103375,
0.013400097,
-0.0059534158,
-0.025018755,
0.014552794,
-0.005697989,
0.015430416,
0.010937518,
0.023315908,
-0.00081417384,
-0.026132155,
-0.061669268,
0.013079177,
-0.010799981,
0.0023627004,
-0.00802303,
-0.013052979,
0.0027851376,
-0.013937149,
-0.0024674912,
0.015915072,
-0.009280518,
0.022215607,
-0.019150482,
0.0033205522,
-0.025739191,
-0.01460519,
0.016308038,
-0.0058322516,
0.02842445,
0.028345857,
0.003060213,
-0.021521369,
0.0082850065,
0.004001691,
-0.014317015,
0.023604082,
-0.01715946,
0.012915441,
-0.0066902246,
0.011088155,
0.02040797,
-0.035969373,
-0.022228705,
-0.0007220727,
-0.015417317,
-0.019045692,
0.0037986592,
0.046605617,
0.014238423,
0.027009776,
0.0036512974,
-0.030913226,
0.033375807,
0.00287028,
-0.012417686,
0.01583648,
-0.029524751,
0.0045944126,
0.012168808,
-0.014408708,
0.02173095,
0.009116782,
0.017670315,
-0.02173095,
0.019176679,
0.02250378,
-0.0068899817,
-0.025804685,
-0.0031830145,
-0.016059158,
0.006467545,
0.014801672,
0.018482441,
0.004021339,
-0.008108173,
-0.0115204165,
-0.033611584,
-0.0076628127,
0.008278457,
-0.024756778,
-0.021089109,
0.036126558,
0.009352561,
-0.00935911,
0.0044732485,
0.013622778,
-0.021691654,
-0.013845458,
-0.029367566,
0.019137383,
0.011802041,
-0.015194637,
-0.020630648,
-0.010793432,
0.034083143,
-0.0037266156,
-0.012214654,
0.023342106,
0.010793432,
0.0070602666,
-0.01326256,
0.0060418327,
0.003107696,
0.010262929,
0.03725306,
0.01850864,
-0.016871287,
0.021586863,
-0.0033369255,
0.038379557,
0.0029734331,
-0.009103683,
0.010262929,
-0.011120902,
-0.009680032,
0.0060123606,
-0.039610848,
-0.0401348,
-0.01460519,
0.005776582,
-0.0015931446,
-0.009549043,
0.0040508118,
-0.009051288,
-0.036833894,
-0.0041261297,
-0.012090215,
0.003510485,
0.0007613692,
0.022464484,
0.0052329805,
0.01681889,
0.009215023,
-0.014775475,
0.0032534206,
-0.011821689,
0.028555438,
-0.0045747645,
0.024272121,
-0.0045747645,
0.012777904,
0.03544542,
-0.037148267,
-0.022726461,
0.014159829,
-0.0022824702,
0.009372209,
0.024376912,
-0.019451754,
0.083675295,
0.005216607,
-0.047994096,
0.0068375864,
-0.012574872,
0.013753766,
-0.0133739,
0.026223848,
-0.020656846,
-0.033716377,
0.024219727,
-0.032196913,
0.024625791,
-0.04534813,
-0.0151422415,
0.0267478,
0.007053717,
-0.004702478,
0.03324482,
-0.0006238315,
-0.0048956857,
-0.02921038,
0.0012771355,
0.02275266,
-0.045662504,
-0.008533885,
0.040501565,
-0.008599378,
-0.0016168862,
-0.040265787,
-0.00713231,
-0.010754135,
-0.042204414,
0.0030962348,
0.025097348,
-0.02129869,
-0.019202877,
-0.02597497,
0.01960894,
0.016687904,
-0.0020728891,
-0.0004396293,
-0.014631387,
-0.02308013,
-0.0025559082,
-0.0012828661,
-0.0056357696,
-0.0055113304,
-0.010269479
] |
OBJECTIVE To determine whether hypoalbuminemia is an independent risk factor for poor outcome in the acutely ill, and to assess the potential of exogenous albumin administration for improving outcomes in hypoalbuminemic patients. SUMMARY BACKGROUND DATA Hypoalbuminemia is associated with poor outcomes in acutely ill patients, but whether this association is causal has remained unclear. Trials investigating albumin therapy to correct hypoalbuminemia have proven inconclusive. METHODS A meta-analysis was conducted of 90 cohort studies with 291,433 total patients evaluating hypoalbuminemia as an outcome predictor by multivariate analysis and, separately, of nine prospective controlled | [
-0.0027587125,
-0.015546118,
0.023069281,
-0.04000955,
-0.028566977,
0.020478262,
-0.015138394,
0.014296642,
-0.00849644,
0.00017426908,
-0.01633526,
0.0072666924,
0.0032009615,
0.02875111,
-0.025844434,
-0.013040588,
0.052583233,
-0.0010875377,
-0.010955936,
-0.0007266692,
-0.020425653,
0.012475036,
-0.019215632,
-0.009081721,
0.0040213414,
-0.0038306317,
0.025121054,
-0.05339868,
0.039641283,
-0.03138159,
0.0077927876,
-0.0134022795,
-0.024871157,
-0.008746335,
0.006618937,
-0.008378069,
0.0022868707,
-0.0027948816,
0.014362403,
-0.0041988986,
0.029724387,
0.022490576,
0.0010250639,
-0.016927117,
-0.0065531754,
-0.0116398595,
0.025712911,
-0.032486387,
-0.0204125,
0.021320015,
0.009285583,
0.00028524233,
0.0063164323,
0.010765227,
0.0013119503,
-0.006309856,
-0.010054997,
0.02875111,
0.009075145,
-0.011146645,
-0.018992042,
0.009614393,
-0.011889755,
0.0031368437,
-0.017755719,
-0.0024726482,
0.009009383,
0.017689956,
0.002293447,
0.011731926,
0.018544862,
0.031486806,
-0.023292871,
-0.013481193,
0.032486387,
0.00091737875,
-0.030118959,
-0.0103180455,
-0.004313982,
0.0187553,
0.028330235,
-0.004859806,
-0.007832245,
0.032539,
0.012323784,
-0.009469717,
-0.019886404,
0.015927536,
0.0021043813,
-0.010252283,
0.0012215277,
0.011922636,
0.03222334,
0.014046746,
0.017255928,
0.017900394,
0.005142582,
0.02279308,
0.0005667856,
0.0011409693,
-0.0066353776,
0.00033826288,
-0.026225854,
-0.009403954,
-0.03619536,
0.014349251,
-0.02229329,
-0.003735277,
0.010410112,
-0.0057278634,
-0.010574517,
0.053661726,
-0.005583187,
-0.030566141,
-0.0029740827,
-0.0022096005,
-0.004172594,
-0.00094697165,
-0.012935369,
-0.0051590228,
0.010863869,
0.0074508255,
0.02080707,
-0.013231298,
-0.008292578,
-0.0017657075,
-0.031565722,
-0.02714652,
0.00025256688,
-0.010798107,
0.0039588674,
0.016966576,
0.037984084,
0.012672322,
-0.024134625,
0.008003226,
-0.039746504,
-0.020662395,
-0.013560108,
-0.05545045,
0.0019728576,
0.01649309,
0.00033744084,
-0.018860519,
-0.03564296,
0.033722714,
0.021333167,
0.00037319888,
-0.009035688,
0.011718774,
-0.011317627,
-0.0128564555,
-0.018992042,
0.000009459698,
0.01500687,
0.0115280645,
0.003981884,
0.026962386,
-0.028935244,
-0.027383264,
-0.016308956,
-0.006155316,
-0.023726901,
0.0043337103,
0.012021279,
0.005780473,
0.0019153159,
-0.013704784,
0.016098518,
0.0031319114,
-0.01825551,
0.017124403,
-0.015756557,
-0.0086608445,
-0.008430678,
0.012922217,
0.00060870877,
0.03306509,
-0.037221245,
-0.041719362,
-0.020333586,
0.022372205,
0.018268662,
-0.00027537803,
-0.011909484,
0.018058224,
0.03569557,
-0.008036107,
0.0037484295,
-0.023306025,
-0.0010324621,
0.020570328,
-0.013639023,
0.01194894,
-0.63257706,
-0.025305187,
-0.010567941,
0.010429841,
-0.003524839,
0.0028557114,
-0.00240031,
0.02024152,
-0.012553951,
0.01616428,
0.005172175,
0.031434197,
-0.0069970684,
-0.028225016,
0.03232856,
-0.026436292,
-0.0046625203,
-0.030355701,
0.022766776,
-0.026462596,
-0.031302676,
0.005869251,
-0.01644048,
0.002091229,
0.008036107,
0.016900813,
0.029198293,
-0.015756557,
-0.006517006,
0.006753749,
0.0021668551,
0.018413337,
0.0137310885,
0.015309375,
0.04926883,
-0.029540254,
0.0051294295,
0.0016621326,
0.010061574,
0.008798945,
0.012672322,
-0.019097261,
0.031407893,
-0.006872121,
-0.03343336,
0.03217073,
0.012553951,
0.022056548,
0.0031450638,
-0.0073587587,
0.027488483,
-0.0011163086,
-0.027041301,
-0.011284745,
0.0011574097,
-0.00050554477,
0.00033004265,
-0.026659882,
-0.012764389,
0.007490283,
-0.014849042,
-0.004212051,
-0.042745247,
-0.013494346,
-0.020885985,
0.020938596,
-0.018544862,
0.013691632,
0.010337774,
0.009686731,
0.005602916,
0.013652175,
0.0010078014,
0.007161473,
0.03322292,
0.008154478,
-0.007740178,
0.025226273,
-0.026462596,
0.013441737,
0.0106468545,
0.013448313,
0.0039555794,
0.0152830705,
0.04484963,
0.017019184,
-0.02669934,
0.02162252,
0.010929631,
-0.006517006,
0.0065367348,
0.012777541,
-0.004484963,
-0.015966995,
-0.02830393,
0.032591607,
-0.011580674,
0.008983078,
0.025055291,
-0.016032755,
-0.0038141913,
-0.015085785,
-0.004886111,
0.0052839704,
0.0037615818,
0.005270818,
0.0037911746,
0.011429422,
0.041245878,
-0.023595376,
0.030776579,
0.00061569596,
0.001542939,
-0.005524001,
0.045665078,
-0.02405571,
0.0037615818,
-0.0042942534,
-0.003215758,
-0.023976795,
0.0369582,
0.004613199,
0.037931476,
0.00918694,
0.0012856455,
0.024029406,
-0.013093199,
-0.031881377,
-0.014244032,
-0.019123565,
-0.004511268,
0.0051951916,
0.026212702,
-0.015743403,
0.041666754,
-0.0007369445,
0.027278045,
-0.0020780766,
-0.011534641,
-0.03895736,
-0.019228786,
-0.016348414,
0.007838821,
-0.0037714462,
-0.013836307,
-0.019005194,
-0.009910321,
-0.007990073,
0.00043649474,
0.017071795,
-0.008318882,
-0.00863454,
-0.019241938,
0.038694315,
-0.021214794,
-0.022017092,
0.024489738,
-0.012179107,
-0.0013793563,
-0.007700721,
0.012225141,
0.021425234,
-0.013639023,
-0.0028146103,
-0.012764389,
-0.0347486,
0.00093710737,
0.017006032,
-0.005037363,
-0.009884017,
0.003422908,
-0.033643797,
-0.018663233,
0.022148615,
-0.007194354,
0.008956773,
-0.0018232493,
0.0029001005,
-0.014770127,
-0.0076415353,
0.005333292,
-0.021214794,
-0.0108704455,
0.020544024,
0.027593702,
-0.002671578,
0.010771803,
0.007240387,
-0.010607397,
0.024121473,
-0.021609366,
0.006878697,
-0.026725644,
0.008312306,
-0.010778379,
-0.013652175,
-0.011843721,
-0.016282652,
-0.0011730283,
0.0075494684,
0.01809768,
-0.012941945,
0.025739215,
-0.013967832,
0.024858005,
0.021635672,
-0.0006641954,
0.0075626206,
0.0027998136,
-0.0072798445,
0.0011713842,
-0.014112508,
0.016782442,
-0.019899556,
-0.0066616824,
0.0074574016,
0.005339868,
-0.008193935,
-0.021359472,
0.006793206,
0.006033656,
0.013823155,
0.029987436,
-0.002877084,
-0.005234649,
-0.021543605,
0.017321689,
0.012264598,
0.004892687,
0.0011352152,
-0.005063668,
0.004182458,
0.0064874133,
0.0037221247,
0.010660008,
-0.012034431,
0.004701977,
-0.021898719,
0.00533658,
0.02074131,
-0.020544024,
0.010995393,
-0.0015708879,
0.0047545866,
0.0010160217,
-0.002604172,
-0.0017032337,
0.03006635,
-0.009456564,
0.009154059,
0.020596633,
0.0078059398,
0.0065893442,
-0.01980749,
-0.016664071,
-0.01611167,
0.00054500194,
-0.006323009,
0.03338075,
0.0162695,
0.023082433,
0.024305606,
-0.011994974,
-0.0139546795,
0.01699288,
-0.026962386,
0.010712617,
0.0095420545,
-0.0062868395,
0.018715842,
-0.04153523,
-0.019110413,
0.011350507,
0.0004385498,
0.0053694607,
0.017400604,
0.017966157,
0.002125754,
0.03766843,
-0.01302086,
-0.03651102,
-0.018571166,
0.018873671,
0.021438386,
-0.0016999457,
0.0005347266,
-0.003115471,
0.018360728,
-0.007536316,
0.012198837,
-0.00070365256,
-0.00369582,
-0.0063821943,
-0.018268662,
-0.001265917,
-0.0031598601,
0.027120216,
-0.004958449,
0.016821899,
-0.028882636,
0.0004009422,
-0.011153221,
-0.008095292,
-0.006944459,
0.034169894,
0.0027767972,
-0.0048565175,
-0.021333167,
-0.0045507248,
0.0019251802,
-0.001852842,
-0.011593826,
0.008003226,
0.012146226,
0.018952586,
0.01122556,
-0.014480774,
0.015204156,
0.02664673,
0.0073587587,
0.0075626206,
-0.011370236,
0.005685118,
0.0114162695,
0.00882525,
0.00397202,
-0.0047776033,
0.035984922,
0.01892628,
0.021951329,
0.0029609303,
-0.041272182,
0.016203737,
0.009522326,
-0.014086204,
0.02239851,
0.017347995,
0.00882525,
0.008739759,
0.02410832,
0.009022536,
-0.043771133,
-0.0041265604,
0.0013251026,
0.010489026,
-0.00013727801,
0.016532546,
0.035485134,
0.008239969,
-0.017137555,
0.00077927875,
0.022306442,
0.0069181537,
-0.00827285,
-0.019912709,
0.0034097556,
-0.015822317,
0.008838402,
0.0026074601,
-0.01859747,
0.0039621554,
-0.008200511,
0.018939434,
0.009805102,
0.011830569,
0.02367429,
0.012060736,
0.019623356,
0.0036004651,
0.0053924774,
0.0113110505,
0.04000955,
0.0005256843,
-0.024029406,
0.013717936,
0.011238712,
-0.007950616,
-0.014875346,
0.008022954,
-0.016085366,
0.012382969,
-0.0032387746,
-0.0020073827,
-0.00029983325,
-0.020859681,
-0.009535478,
0.020149453,
-0.0033242651,
-0.009035688,
-0.036432102,
-0.047006622,
-0.013520651,
-0.007740178,
0.00042252033,
0.006299992,
-0.007437673,
-0.0037780222,
0.012251446,
-0.005313563,
0.013875765,
0.012948522,
-0.013126079,
0.008588507,
0.0069181537,
-0.018387033,
0.0084372545,
-0.00034853816,
-0.034064673,
0.016072214,
-0.006247382,
-0.005760744,
-0.011442574,
-0.018031918,
0.011521488,
-0.014493927,
-0.014770127,
0.0038174794,
0.016624613,
0.020031082,
-0.009042264,
0.012935369,
-0.0000111679665,
-0.01390207,
-0.032565303,
0.0037319888,
-0.012488188,
-0.02946134,
-0.016374718,
0.012165955,
-0.025042139,
-0.038694315,
-0.027988274,
0.033459663,
-0.009009383,
0.0050998367,
0.006691275,
-0.0022046682,
-0.020885985,
0.018281814,
0.016019603,
-0.018676385,
0.014612298,
0.020649243,
-0.0004009422,
-0.009456564,
0.00022091896,
0.025265729,
0.011100612,
-0.01633526,
0.020044234,
0.017400604,
-0.028830025,
-0.042508505,
-0.022096004,
-0.014204575,
0.02531834,
-0.019347157,
-0.006872121,
-0.04292938,
-0.0087660635,
-0.009805102,
-0.008115021,
-0.012244869,
-0.038063,
0.0026206125,
-0.016059062,
-0.011113765,
-0.018110832,
0.023569072,
-0.029382426,
-0.025015835,
0.021780347,
-0.015112089,
-0.00024578517,
0.002673222,
0.010548212,
-0.022359053,
-0.010936207,
-0.024594959,
-0.021754043,
0.0044948272,
0.000857371,
0.042666335,
0.011048002,
0.037326466,
0.012507917,
0.020530872,
0.017926699,
0.023792662,
0.019662814,
-0.0013201706,
0.0073850635,
0.005777185,
0.014336099,
0.019557595,
-0.0050077704,
0.022740472,
-0.026396835,
0.02134632,
0.019978471,
-0.015454051,
-0.04071978,
-0.016151128,
-0.017190166,
-0.01963651,
0.0176505,
-0.003768158,
0.0128564555,
-0.05153104,
-0.0044816746,
-0.029303512,
0.0156118795,
0.0041166963,
-0.022096004,
0.03293357,
-0.017032336,
-0.01726908,
0.02405571,
-0.01963651,
0.00973934,
-0.018663233,
-0.0037550055,
-0.000041717718,
0.013132655,
0.0017558433,
0.019768033,
-0.0011253508,
-0.0009658782,
-0.021083271,
0.0031910972,
-0.012488188,
-0.0058495225,
-0.017229622,
-0.027356958,
0.0076218066,
-0.0049551604,
-0.004136425,
-0.014993718,
0.0030628615,
0.016887661,
0.001400729,
0.017887242,
-0.016032755,
-0.0017574873,
0.01633526,
-0.031565722,
-0.01837388,
-0.019452376,
0.041587837,
0.021280557,
-0.029934825,
-0.017545281,
0.016848205,
0.00031750675,
-0.0014237455,
0.028619587,
0.02471333,
-0.022701014,
-0.013678479,
-0.005879116,
0.012369817,
-0.02906677,
-0.010903326,
0.030382007,
0.032144427,
0.01334967,
-0.0010036913,
-0.03574818,
-0.016887661,
0.020451957,
-0.0036070412,
-0.015204156,
0.016190585,
-0.028119797,
0.009752492,
0.032012902,
-0.020767614,
0.016137974,
0.0048137726,
-0.005484544,
0.007496859,
-0.0049387203,
-0.037589513,
0.01661146,
-0.022766776,
0.024634415,
-0.00096752227,
0.015980147,
-0.004241644,
0.00029983325,
0.0056686774,
-0.005004482,
-0.015322527,
0.0375106,
-0.017190166,
-0.0059415894,
0.040088467,
-0.0038602247,
-0.017203318,
-0.029093074,
-0.009094873,
-0.017084947,
-0.010541636,
0.018176595,
0.016453633,
0.027409568,
-0.015309375,
0.016558852,
-0.016532546,
0.0075165876,
0.0014163473,
-0.014467622,
0.008397797,
-0.027514787,
-0.0024742922,
-0.0150594795,
-0.008904164,
0.015572422,
0.0124092745,
0.006263823,
-0.009482869,
-0.007148321,
-0.03217073,
0.028987855,
0.019978471,
-0.0023789376,
-0.020557176,
0.008101868,
-0.042903077,
-0.00080599455,
0.0070759826,
0.008963349,
-0.025975958,
0.0009773865,
-0.00739164,
0.034617074,
0.0075494684,
0.011633283,
0.021490995,
0.027278045,
0.0038470724,
0.010850716,
-0.018965738,
0.03193399,
-0.028119797,
0.028987855,
0.017834632,
-0.008101868,
-0.0017624195,
0.009160635,
0.024450282,
-0.013468041,
-0.0071746255,
0.016479937,
0.0009297091,
0.04221915,
-0.01704549,
-0.008746335,
-0.0073456066,
-0.017532127,
-0.024647567,
-0.00045499028,
0.01417827,
0.009246126,
-0.024700178,
0.005034075,
-0.004965025,
0.020609785,
0.002500597,
0.0014673128,
0.005510849,
-0.008443831,
-0.0137310885,
-0.0020106707,
-0.0036728033,
0.018202899,
0.008470135,
-0.016821899,
-0.017111251,
0.008161054,
-0.035669263,
0.015901232,
-0.00739164,
0.026462596,
-0.0011121985,
0.012356665,
-0.010988817,
0.042166542,
-0.008055835,
0.015072632,
-0.0033768746,
-0.016795594,
0.020254672,
-0.02156991,
0.038825836,
-0.008463559,
-0.0347486,
-0.016913965,
0.032302257,
0.011620131,
0.00037463743,
0.02080707,
0.004685537,
0.001576642,
-0.038220827,
0.033038788,
0.010173369,
-0.02576552,
-0.01315896,
-0.01089675,
-0.015927536,
0.0073456066,
0.013481193,
0.008325459,
0.007865125,
-0.0012042652,
0.007832245,
0.0010875377,
-0.015809165,
-0.018031918,
0.02008369,
-0.012915641,
-0.016861357,
0.030118959,
-0.01172535,
-0.006944459,
-0.006944459,
0.013757394,
-0.010600821,
0.014441318,
-0.00043320665,
0.001918604,
0.010949359,
-0.004527708,
-0.026936082,
0.011633283,
0.009226398,
-0.008391221,
-0.0059218607,
0.022595795,
-0.011245288,
-0.0034557888,
0.0073784874,
-0.009035688,
-0.010890174,
-0.0022441256,
-0.015598727,
0.0037911746,
0.009226398,
-0.0077927876,
0.011383388,
-0.006957611,
-0.016782442,
-0.024831701,
-0.007227235,
-0.001644048,
0.0022474136,
-0.022832539,
-0.009502597,
0.012547375,
0.19244568,
-0.028172407,
-0.003396603,
0.0025170376,
-0.0029954554,
-0.006247382,
0.021767195,
0.013270755,
-0.0076349587,
0.01638787,
0.01882106,
0.0082136635,
-0.011179526,
-0.0037484295,
0.011409693,
-0.005882404,
-0.020675547,
-0.025897045,
-0.009634121,
0.002983947,
-0.018899975,
0.0046460796,
0.015598727,
0.016059062,
0.056029156,
-0.0071022874,
0.007825669,
0.012770965,
0.024410825,
0.0347486,
-0.011337355,
-0.009844559,
-0.008759487,
0.0069707637,
0.007161473,
0.01825551,
-0.022964062,
-0.017479518,
-0.022582643,
-0.007970344,
-0.013080046,
0.013007708,
-0.02840915,
-0.004623063,
0.017453214,
-0.003870089,
0.003597177,
-0.0150594795,
-0.020162605,
0.006599209,
-0.018123984,
-0.008937045,
0.0032634353,
0.00739164,
-0.016374718,
0.009614393,
0.027935663,
-0.00030312134,
-0.0013744241,
0.016006451,
0.0023016671,
-0.0071746255,
-0.021964481,
0.023661138,
-0.0165457,
0.028172407,
-0.015309375,
-0.016256347,
-0.030092655,
-0.00030640943,
0.027935663,
-0.0123040555,
-0.027883055,
0.0071417443,
-0.0052675297,
-0.026054872,
0.036537323,
0.04453397,
-0.0055371537,
0.0026008838,
-0.011159798,
-0.009127755,
-0.027541092,
0.009496021,
-0.0076152305,
-0.028935244,
-0.013546956,
0.00032367193,
-0.014441318,
0.011304474,
0.0032469947,
-0.015598727,
-0.011784536,
-0.0050242105,
0.012251446,
-0.010166793,
0.018860519,
-0.0017591313,
-0.014151965,
-0.014638604,
-0.01859747,
0.08033476,
-0.020346738,
0.02112273,
0.00009874563,
-0.025489321,
-0.038378656,
0.006408499,
0.004965025,
0.00602708,
0.0037550055,
-0.023582224,
0.01194894,
-0.027251739,
0.01859747,
0.02935612,
0.03603753,
-0.026659882,
0.023976795,
-0.022740472,
-0.0165457,
-0.021280557,
0.027251739,
0.005247801,
-0.001338255,
0.0033801626,
0.003255215,
0.01412566,
-0.023621682,
-0.04506007,
0.005168887,
0.0065893442,
0.016742984,
-0.0012231717,
0.013119503,
0.0039259866,
-0.022779929,
-0.009660426,
-0.005859387,
0.040351514,
-0.019439224,
-0.006240806,
0.015585575,
0.013007708,
0.010403535,
-0.0064282278,
0.03172355,
-0.0045803175,
-0.03482751,
-0.005856099,
0.007319302,
-0.0043928963,
0.00084093056,
-0.02245112,
0.006691275,
-0.001060411,
-0.002360853,
-0.045533553,
0.012678898,
-0.00885813,
-0.0049880417,
0.011593826,
0.01832127,
-0.0005281504,
-0.016151128,
0.0073850635,
-0.1638261,
-0.000040484683,
0.0022178208,
-0.011120341,
0.020675547,
-0.045980733,
0.0055009844,
0.008785793,
-0.022687862,
-0.029014159,
0.014520232,
-0.005602916,
-0.02035989,
-0.03369641,
0.011186102,
-0.0013530515,
0.0074179447,
0.015940689,
0.020570328,
0.005438511,
-0.003630058,
0.0019120278,
0.037878867,
0.0019054516,
0.017019184,
0.011613555,
-0.010331198,
0.03293357,
-0.007773059,
0.0062210774,
-0.0059087086,
-0.01947868,
0.036721457,
0.017755719,
-0.00794404,
-0.0119686695,
0.008450407,
0.000376898,
0.021451538,
0.012613136,
0.02421354,
0.029698083,
0.011422846,
0.011837145,
-0.023437548,
0.030829187,
0.029698083,
-0.00328974,
0.03261791,
-0.00445537,
0.0032732997,
-0.004070663,
0.00315164,
0.014230879,
-0.009620969,
0.014756975,
0.0068129348,
0.017321689,
-0.008555626,
0.007128592,
-0.00061117485,
-0.02279308,
0.015085785,
0.016361566,
0.001780504,
-0.015638184,
0.0058330824,
0.0071417443,
-0.01749267,
0.0040312055,
-0.028040882,
-0.022503728,
-0.002120822,
-0.002839271,
0.012810422,
0.040246297,
-0.029040463,
0.007292997,
-0.020333586,
0.016532546,
-0.012481612,
0.00037504846,
-0.019965319,
-0.016953424,
-0.014993718,
0.014415013,
0.016637765,
0.011501759,
-0.013875765,
-0.010883598,
0.04595443,
-0.040535647,
-0.024318758,
-0.0034722295,
0.019399766,
0.028277626,
0.007161473,
0.011541217,
0.013586412,
-0.010574517,
0.005438511,
0.006951035,
-0.025305187,
0.009121179,
0.01749267,
-0.018242357,
-0.017084947,
-0.007786211,
0.02588389,
-0.034169894,
0.005139294,
-0.003768158,
0.02637053,
0.012665746,
-0.0051294295,
0.0067340205,
0.0056588133,
-0.022661557,
0.0019613493,
-0.027014997,
0.05997487,
0.0024923768,
-0.028540673,
0.009561783,
-0.027383264,
-0.02714652,
-0.12699942,
-0.030855494,
0.0036464985,
-0.0054319347,
0.018807909,
0.018531708,
-0.005330004,
-0.0016572004,
-0.020162605,
0.029645473,
-0.02714652,
-0.003149996,
-0.035958618,
-0.025975958,
0.04574399,
0.030539835,
0.020793919,
-0.014796432,
-0.01683505,
0.026778253,
0.013468041,
-0.0004282745,
0.011712198,
-0.0022539897,
0.0008265451,
-0.0201363,
-0.017177014,
0.035537742,
0.013454889,
0.010554788,
0.016585156,
0.0032667234,
0.0013226366,
-0.020951748,
-0.01412566,
-0.020557176,
-0.0045737415,
-0.0057015587,
0.031881377,
-0.012981403,
-0.0016243195,
0.019768033,
0.013132655,
-0.006852392,
0.009614393,
0.016506242,
-0.023477005,
0.009726188,
0.018163443,
-0.009785374,
-0.020504566,
-0.034406636,
-0.02141208,
-0.0028540674,
0.005579899,
-0.003015184,
0.010416688,
0.021977633,
-0.0005556882,
0.0087726405,
0.013343094,
0.03438033,
-0.017926699,
0.0039917487,
0.004346863,
-0.0413774,
0.008128174,
-0.021885566,
0.010949359,
-0.017637346,
-0.022661557,
0.015243613,
-0.0041068317,
-0.011113765,
-0.040035855,
-0.0056686774,
-0.024989529,
-0.026331073,
0.017900394,
-0.022253834,
-0.023726901,
-0.013270755,
0.0032683674,
-0.010179945,
-0.0042745247,
0.016900813,
0.028277626,
-0.009535478,
0.0039029699,
-0.00766784,
-0.00404107,
0.025331492,
0.026252158,
-0.013080046,
0.00081996893,
-0.0195839,
0.008798945,
-0.030987017,
0.015296223,
-0.0038141913,
-0.008049259,
0.0015100581,
-0.042718943,
0.0027192554,
0.013770546,
-0.020504566,
0.0040936796,
-0.016979728,
0.005971182,
-0.0034393484,
0.00058404804,
0.0069313063,
-0.030750273,
0.0012913997,
-0.036931895,
0.0028244744,
-0.004590182,
-0.007970344,
0.036432102,
-0.00068269094,
0.02642314,
0.017966157,
-0.0047710272,
0.008338612,
0.006405211,
0.024174081,
-0.005043939,
0.001233858,
0.011232136,
0.012573679,
-0.0069050016,
-0.01616428,
0.01699288,
-0.031302676,
-0.0184791,
-0.023753205,
-0.030460922,
-0.031855073,
0.013428584,
0.010133912,
0.011337355,
0.008673998,
-0.019833796,
-0.027514787,
0.02339809,
-0.030776579,
-0.0026255446,
0.023240263,
-0.01815029,
0.01683505,
-0.009140907,
-0.030987017,
0.027462177,
0.02654151,
0.0078914305,
-0.016019603,
-0.013560108,
0.031697243,
-0.0011360372,
0.015177851,
-0.020649243,
0.0013464753,
0.016519394,
-0.02554193,
0.006073113,
0.016098518,
0.0069050016,
0.0085490495,
0.012816998,
0.013967832,
0.036458407,
-0.0034853818,
-0.014099356,
0.011922636,
-0.025620844,
-0.019531291,
0.012205413,
0.0039983247,
-0.012646018,
0.041456316,
-0.002398666,
0.010824412,
0.018544862,
-0.000342373,
-0.024726482,
0.025739215,
0.027777836,
0.0053891893,
-0.008581931,
0.03427511,
-0.008733183,
0.00830573,
-0.032460082,
0.0058758277,
-0.014296642,
0.006168468,
-0.0045441487,
0.008595083,
-0.00973934,
0.019268243,
-0.002811322,
0.010541636,
-0.0043731676,
-0.015848622,
-0.003386739,
-0.012317208,
-0.022806235,
0.008877859,
-0.01947868,
-0.039509762,
-0.0026551376,
0.009482869,
0.013888918,
0.0019975184,
0.0030053197,
-0.00822024,
-0.021885566,
-0.0065893442,
0.011856874,
0.0078059398,
-0.008700302,
0.0021306863,
-0.0054944083,
0.016795594,
0.0021980922,
0.012343512,
0.0011574097,
0.01704549,
0.017584737,
-0.012915641,
0.027041301,
-0.006944459,
0.013053741,
-0.037063416,
-0.03206551,
-0.0003390849,
0.021556757,
-0.038457572,
0.040535647,
0.0026962387,
0.0020435518,
0.06523582,
0.0007665374,
-0.0036366342,
0.008792369,
0.0004175882,
0.0004145056,
-0.0010267079,
0.0089896545,
-0.012488188,
0.0039917487,
0.013691632,
0.0049387203,
0.026291616,
-0.055397842,
-0.017032336,
0.012119922,
0.008404373,
0.019794337,
0.013757394,
-0.0036136175,
0.004965025,
0.0005371927,
0.0012133074,
0.010456145,
-0.012481612,
-0.0029740827,
0.033722714,
-0.009114602,
-0.023306025,
-0.034222502,
-0.014336099,
0.02935612,
-0.021780347,
-0.028514368,
0.011837145,
-0.017611042,
-0.022556338,
-0.00081092666,
-0.00835834,
-0.019820642,
-0.0132904835,
0.011810841,
-0.014296642,
-0.013336517,
-0.029224597,
-0.050952334,
-0.0391678,
-0.0073521826,
0.011679317
] |
Reduced dietary methionine intake (0.17% methionine, MR) and calorie restriction (CR) prolong lifespan in male Fischer 344 rats. Although the mechanisms are unclear, both regimens feature lower body weight and reductions in adiposity. Reduced fat deposition in CR is linked to preservation of insulin responsiveness in older animals. These studies examine the relationship between insulin responsiveness and visceral fat in MR and test whether, despite lower food intake observed in MR animals, decreased visceral fat accretion and preservation of insulin sensitivity is not secondary to CR. Accordingly, rats pair fed (pf) control diet (0.86% methin | [
-0.0051803165,
-0.015605407,
-0.0028853042,
-0.011880464,
-0.016311042,
0.013949877,
-0.0035790661,
-0.022865314,
-0.034169056,
-0.011066269,
0.0032126785,
0.026271364,
0.009403954,
-0.002064324,
-0.017803734,
0.009363244,
0.046029165,
-0.0012034822,
0.022471786,
-0.0015571482,
-0.011113764,
0.010686311,
0.007890908,
-0.025063641,
0.007232767,
-0.009872116,
0.007877338,
-0.035743166,
-0.0072599067,
-0.022227528,
0.024371576,
-0.0038402872,
-0.0120500885,
-0.013610629,
-0.0031770573,
0.020748407,
0.0011890641,
-0.0034043535,
0.015483278,
-0.043993678,
0.021155505,
0.00024574276,
0.007748424,
0.013678479,
0.0008260688,
-0.0054415376,
0.0023458998,
-0.01522545,
-0.0034942543,
0.009512513,
0.018292252,
0.03001666,
-0.029121047,
0.011351237,
-0.015062611,
0.008148736,
-0.0044882507,
0.02359809,
-0.014031297,
-0.02182043,
0.007897693,
-0.0023017975,
-0.037670095,
0.0034162272,
-0.010638816,
0.004149003,
-0.002496865,
0.012925348,
0.007931618,
0.02015133,
0.018767199,
0.03520037,
-0.009471804,
0.013583489,
0.031400792,
-0.006350722,
-0.008209801,
0.021481182,
0.03506467,
-0.02699057,
0.03639452,
0.0011848236,
0.0011729499,
0.038185753,
0.02509078,
-0.013339231,
0.004433971,
0.019662812,
0.013291736,
0.0045561003,
-0.007972328,
0.020449867,
0.018740058,
0.034386177,
-0.011073054,
-0.004885171,
-0.01671814,
0.004729117,
0.00065008394,
-0.009078276,
-0.019717094,
0.014723362,
-0.0011950011,
-0.01086272,
-0.00909863,
-0.0034450633,
-0.020789117,
-0.014221275,
0.012450401,
-0.034874693,
-0.008582974,
0.030613737,
0.009451449,
-0.04551351,
-0.003266958,
0.000685705,
0.02036845,
-0.0086304685,
-0.009505728,
-0.007951973,
0.020612707,
0.0133053055,
0.030070942,
-0.0018794339,
-0.0035451413,
0.010157084,
-0.007076713,
-0.0009108808,
-0.0023713433,
0.0045798477,
0.016243193,
-0.02674631,
0.006371077,
0.012857499,
-0.02874109,
0.04369514,
-0.024615834,
-0.0065373085,
-0.0052006715,
-0.03840287,
0.0036163835,
0.014601233,
-0.022213958,
-0.0064524966,
-0.019377844,
0.030478038,
-0.0060962862,
0.00085744925,
-0.012674305,
-0.010693097,
-0.021874709,
-0.006879949,
0.02514506,
-0.0072395517,
0.023231702,
0.015211879,
-0.006164136,
0.02186114,
-0.0200292,
-0.015944656,
-0.0034264047,
-0.026217084,
0.013759898,
0.024507275,
0.0015749588,
0.0051667467,
0.011683701,
-0.009770342,
-0.000020606665,
0.010984849,
0.028795369,
0.024439424,
-0.008236941,
0.036611643,
-0.016528161,
0.026597042,
-0.017111668,
0.0055161724,
-0.0024697252,
-0.028333992,
-0.018943608,
0.007700929,
0.035824586,
0.024005188,
0.0011661649,
0.0183601,
0.016378893,
-0.0016886068,
-0.007219197,
-0.022159679,
0.006737465,
0.01350207,
-0.0077891336,
-0.024168026,
-0.6409344,
-0.036041707,
-0.015822526,
-0.00928861,
0.015483278,
0.029880961,
0.008888297,
0.010048525,
-0.0009125771,
0.02032774,
0.0086711785,
0.027926894,
0.007951973,
-0.05710222,
0.0017793557,
-0.03861999,
-0.013732758,
-0.009865331,
-0.01176512,
-0.0042948793,
-0.041659653,
0.01508975,
-0.018210832,
0.001647049,
0.009336105,
0.01823797,
0.01855008,
0.00021372623,
0.0072870464,
0.012409691,
0.003548534,
0.032133568,
0.0031804498,
0.01667743,
0.056613702,
-0.017735884,
0.0015859843,
0.020666987,
0.026556332,
0.049964443,
-0.016609581,
0.0087729525,
0.048987407,
0.019391414,
-0.02538932,
0.01339351,
0.0015961617,
0.017423777,
0.015836095,
-0.001803103,
0.013963447,
0.019839222,
-0.034956113,
-0.009512513,
0.032730646,
-0.021549031,
0.02688201,
-0.037941493,
-0.007904478,
0.029012488,
0.011385162,
0.013033908,
-0.021155505,
-0.011575141,
-0.02685487,
0.030749436,
0.0028836078,
0.0037486902,
0.00763308,
-0.026719172,
0.017573046,
0.02863253,
-0.01511689,
-0.002997256,
0.027560506,
0.02001563,
0.021915419,
0.022241097,
-0.0337891,
0.010177439,
0.0098042665,
0.0019421946,
-0.00755166,
0.011296958,
0.012396121,
-0.004752864,
0.000018632136,
-0.01347493,
-0.004919096,
-0.009526083,
0.009363244,
-0.0046544825,
0.001803103,
-0.015388289,
-0.013054262,
0.0077959187,
0.0021898458,
-0.00028687657,
0.0084812,
-0.02522648,
-0.027546937,
-0.0056620487,
0.014669083,
0.013705619,
0.008026607,
-0.005967372,
-0.023245271,
-0.00052625843,
0.024547983,
-0.0045561003,
0.008257296,
-0.0019846007,
-0.024290156,
-0.0039725937,
-0.00061149447,
-0.019404985,
0.0121111525,
0.0061132484,
-0.019038597,
-0.039027087,
0.008962932,
-0.0022254668,
0.029419584,
0.009654998,
0.010659171,
0.01827868,
-0.0038979594,
0.0042948793,
-0.0032160708,
-0.007979113,
0.013963447,
0.0369916,
0.02863253,
-0.022431076,
0.01005531,
0.012321487,
0.022458216,
-0.018740058,
0.009295395,
-0.012443616,
-0.011622636,
0.0041049006,
-0.0025002577,
-0.013807393,
-0.0046510897,
-0.028035453,
0.015958225,
0.013312091,
0.027899753,
-0.009030782,
0.011439442,
-0.008203017,
-0.0042406,
0.01269466,
-0.0031906273,
-0.0013519032,
0.0043796916,
-0.03514609,
-0.012335056,
-0.019866362,
0.0013061047,
0.013854887,
-0.02681416,
-0.005288876,
-0.008433705,
-0.021250494,
0.03026092,
0.009444664,
-0.029039627,
-0.009790697,
0.0008761079,
-0.01257253,
0.0045289607,
0.004037051,
-0.008474414,
0.031400792,
-0.0268413,
-0.005743468,
-0.02036845,
-0.0023798246,
0.0024205344,
-0.0018539903,
-0.011466581,
0.007884123,
0.029121047,
0.0022237706,
0.008189446,
0.023055293,
-0.02514506,
0.029555283,
-0.0040268735,
0.020721266,
-0.009580363,
0.009030782,
0.009403954,
-0.014913341,
0.00021298412,
-0.014533384,
0.0061980607,
0.0035247866,
0.012335056,
-0.032920625,
0.024534414,
-0.041089714,
0.03210643,
-0.02190185,
0.0016309347,
-0.014764072,
0.022173248,
0.0056315167,
-0.0092479,
0.018699348,
-0.016026074,
0.001916751,
0.005685796,
-0.0010143515,
-0.016243193,
-0.0017505196,
-0.025877835,
-0.0026919327,
0.00755166,
-0.002191542,
-0.0010754161,
-0.016256763,
-0.0022237706,
0.026176374,
0.0060657538,
0.02518577,
-0.013101757,
-0.014289125,
-0.013990587,
0.003090549,
0.008732243,
0.009017211,
0.02008348,
-0.0010067184,
-0.0008260688,
-0.016188914,
0.020341309,
0.024181597,
0.02359809,
0.011860109,
0.026203513,
-0.0049530207,
-0.005852028,
-0.018115843,
0.022824604,
0.04860745,
0.0023272412,
0.019160725,
-0.0016385678,
0.034711853,
-0.012823573,
-0.0073481114,
-0.0006606854,
0.016460313,
-0.0014969318,
-0.0053838654,
0.017084528,
0.018740058,
0.0065407013,
0.016650291,
-0.005665441,
-0.012925348,
-0.006109856,
-0.0010262252,
0.010475977,
0.001965942,
0.012938918,
-0.010923785,
-0.028089732,
-0.0027173762,
-0.011860109,
-0.019309996,
0.02874109,
0.0012552175,
0.0304509,
0.007890908,
0.03674734,
0.027601216,
-0.010170654,
-0.035797447,
0.04385798,
0.011595496,
-0.020002062,
-0.013122112,
-0.027424807,
-0.0054618926,
-0.0072870464,
-0.0028581643,
0.012165433,
0.0067917444,
0.023136713,
-0.010238504,
-0.01513046,
-0.013698833,
0.01840081,
-0.043423742,
0.020938385,
0.008189446,
0.0007874794,
0.014682652,
0.017193088,
-0.009268255,
0.033816237,
-0.001591073,
0.0051463917,
-0.012715015,
0.0041320403,
0.0022543028,
-0.005190494,
-0.00022369163,
0.004342374,
0.011588711,
0.022118969,
0.0016860624,
-0.012579315,
-0.012742154,
0.012450401,
-0.01674528,
-0.018740058,
-0.01504904,
-0.026230654,
-0.009973891,
0.044373635,
0.040438358,
0.0060148668,
0.004898741,
0.022987444,
0.0037520826,
-0.0034281008,
-0.04041122,
0.007863768,
-0.010584537,
0.0010618462,
-0.004942843,
-0.000038987015,
-0.015334008,
0.019215006,
0.0051803165,
-0.0075788,
-0.044672173,
-0.024113746,
0.004108293,
0.029582424,
-0.020300599,
0.034928974,
0.046626244,
0.019784942,
-0.015673257,
-0.00753809,
0.028958207,
-0.0010567574,
-0.022783894,
0.02547074,
0.0017420384,
0.009146126,
0.015727537,
0.000883741,
-0.025321469,
0.012538605,
0.00016230896,
0.021264063,
-0.01254539,
0.014560523,
0.017315216,
0.016202483,
0.00841335,
0.011656561,
-0.015836095,
-0.013963447,
0.03362626,
-0.013413865,
-0.022444647,
0.020436298,
0.0018200654,
-0.017355926,
0.00034688105,
0.010923785,
-0.005848635,
0.008908652,
-0.02329955,
-0.019364275,
-0.0076262946,
-0.010808441,
-0.015700396,
0.022458216,
0.0017522158,
-0.022132538,
-0.005600984,
0.00926147,
-0.009186835,
-0.027954035,
0.016378893,
0.008589759,
-0.00456967,
0.0006941862,
0.027845474,
-0.0038911744,
0.0085490495,
0.015605407,
-0.029202467,
-0.011880464,
0.013834532,
-0.019486403,
0.010272428,
-0.001661467,
-0.025999965,
0.0143569745,
0.0019778158,
0.006150566,
-0.028686808,
-0.044102237,
-0.0022339479,
-0.003999734,
-0.013848103,
0.03370768,
-0.013027122,
-0.023367401,
-0.0066424753,
0.0052006715,
0.015035471,
0.0045425305,
-0.011656561,
0.021128364,
0.002376432,
-0.039814144,
-0.034114778,
-0.0025850695,
-0.022173248,
0.010584537,
-0.0015596926,
-0.0016953918,
0.0072395517,
0.015564698,
-0.020422729,
-0.0077891336,
0.004087938,
0.025620008,
0.02673274,
0.0084812,
0.020694127,
0.0032720468,
0.00071157265,
-0.0070156483,
-0.010591322,
0.013386725,
0.010570967,
-0.018889328,
0.005380473,
-0.010333493,
0.004515391,
-0.038267173,
0.016772421,
-0.013712403,
0.05194565,
-0.021454042,
-0.0713235,
-0.03202501,
-0.006632298,
-0.0049462356,
0.011995808,
-0.009349674,
-0.004708762,
-0.031726472,
-0.0042541698,
-0.0066628302,
0.000247439,
0.03340914,
-0.03183503,
0.00377583,
0.0041964976,
0.00068612903,
0.0099467505,
0.005465285,
-0.007395606,
-0.029419584,
0.018740058,
-0.0041761426,
-0.019622102,
0.019852791,
0.0014689438,
0.05555525,
0.02547074,
0.027736915,
0.00072429446,
-0.0028038844,
-0.006937621,
0.02495508,
-0.0041320403,
-0.010638816,
0.027017709,
-0.009566793,
0.0069681536,
0.019730663,
0.0034128346,
0.0077552088,
-0.019391414,
0.011032345,
0.010991635,
-0.0054585002,
-0.027845474,
-0.028171152,
-0.049530204,
-0.0109780645,
0.016989538,
0.008990072,
-0.0072802617,
-0.030912276,
-0.025660718,
0.016080353,
0.008915437,
0.012402906,
-0.01518474,
0.024249446,
-0.04548637,
0.018902898,
-0.009858547,
-0.004708762,
0.0144791035,
-0.014859062,
0.006259125,
-0.0049292734,
0.001816673,
-0.019676384,
0.014194136,
0.022105398,
-0.018957177,
0.02524005,
-0.011113764,
-0.023760928,
-0.02164402,
0.0070156483,
-0.011514076,
-0.011758335,
-0.015890375,
-0.015401858,
-0.010550613,
0.00054873363,
0.00076712447,
-0.024195166,
0.029039627,
-0.0071852724,
-0.018726489,
0.0047596493,
-0.01853651,
0.018224401,
-0.005597592,
0.027397666,
0.015334008,
-0.0053635105,
-0.020544857,
-0.00042448402,
0.023014583,
0.00842692,
0.034684714,
0.029962381,
-0.0026817552,
-0.030857997,
-0.01086272,
0.021345483,
-0.044617895,
-0.05873061,
0.018658638,
0.0020100442,
0.023028152,
-0.008521909,
-0.0046205577,
-0.04195819,
-0.0060691466,
-0.0055602742,
-0.012884638,
0.0041523953,
-0.008155521,
-0.008929007,
0.035878867,
-0.0022712653,
0.011486936,
-0.005648479,
-0.0068901265,
-0.00022644803,
-0.037778657,
-0.01504904,
0.008677963,
0.02852397,
0.03376196,
0.0050514024,
0.0045594927,
0.0024273193,
0.004030266,
0.001683518,
-0.00547207,
-0.013787038,
0.036123127,
0.012233282,
-0.014791212,
-0.016514592,
-0.017152378,
0.017858014,
-0.014723362,
0.0042541698,
-0.01510332,
-0.019499974,
-0.0053635105,
0.017098099,
0.028686808,
-0.0403298,
-0.004074368,
-0.02690915,
0.008576189,
-0.025891406,
-0.021046944,
0.022213958,
-0.01871292,
0.004640912,
-0.00023132471,
-0.009933181,
0.011744765,
-0.006052184,
0.013990587,
-0.005889345,
0.016772421,
-0.041225415,
0.029718123,
-0.009146126,
0.009532868,
-0.0076398645,
0.015673257,
-0.02704485,
-0.012776079,
-0.0060216514,
-0.0013417258,
-0.043043785,
-0.011514076,
0.013441005,
0.004749472,
0.008420135,
0.013386725,
0.0057231137,
0.018292252,
0.013936307,
-0.0041320403,
-0.0058214953,
0.026379922,
-0.0332463,
0.01681313,
0.002898874,
-0.008318361,
0.008236941,
-0.03541749,
0.009465018,
0.028713949,
0.02006991,
-0.00009398229,
-0.024073036,
0.01511689,
-0.026434202,
-0.022987444,
-0.0037317278,
-0.009417524,
-0.032703504,
0.00014948114,
0.006272695,
-0.01508975,
-0.012660734,
0.015564698,
-0.0098246215,
-0.008908652,
-0.027139839,
0.00043932613,
0.0007374403,
0.0076941443,
-0.021101225,
-0.004936058,
-0.020259889,
0.03870141,
0.016609581,
0.0015003242,
-0.0028802154,
0.0028734305,
-0.032242127,
-0.022254668,
-0.0011110371,
0.008060532,
-0.010604892,
0.004298272,
0.008874727,
0.027289107,
-0.014085576,
0.0076466496,
-0.0038708195,
-0.0007259907,
-0.012179002,
0.000051019717,
0.034087636,
-0.008175876,
-0.00841335,
-0.010285999,
0.026244223,
-0.023747358,
-0.0006331215,
0.01005531,
0.0029497612,
0.030803716,
-0.020911245,
0.017491626,
0.03376196,
-0.025592867,
-0.0023306336,
-0.007938403,
-0.0046884073,
0.016121063,
-0.023788068,
0.0016411121,
-0.01853651,
-0.018997887,
0.00506158,
-0.008067317,
0.000247439,
-0.015306869,
0.009376815,
-0.021535462,
0.0008455756,
-0.0040981155,
0.013379941,
-0.0084812,
0.007734854,
-0.03169933,
-0.018875757,
-0.008141952,
-0.011201968,
-0.014370545,
0.012959273,
0.025457168,
-0.0006555967,
0.011575141,
0.018224401,
0.012368982,
0.0073481114,
-0.027899753,
0.00037571715,
-0.0069952933,
0.009797482,
-0.022566775,
0.009349674,
-0.013481715,
0.021033375,
-0.0145198135,
0.004976768,
0.00031931716,
-0.013671693,
0.0004130344,
-0.024412286,
0.012782864,
-0.032784924,
-0.00019538564,
-0.016365323,
-0.01827868,
0.0053669033,
0.027411237,
0.18715632,
-0.0155104175,
0.0069749383,
0.019866362,
-0.0038097547,
-0.004030266,
0.025375748,
-0.002432408,
0.0034467594,
0.027818335,
0.015686827,
0.019540684,
-0.034630433,
0.0068188845,
0.0155104175,
0.0023950906,
-0.030613737,
-0.0016631632,
-0.0029209252,
-0.008990072,
0.005210849,
-0.016636722,
0.0021898458,
0.00068400876,
0.02184757,
-0.00009149094,
-0.024032326,
-0.014166996,
0.014139856,
0.012280777,
-0.011927959,
-0.0058791675,
-0.012240067,
0.008304791,
-0.003633346,
0.0021525284,
-0.019635674,
-0.0024917764,
0.013949877,
-0.012932133,
0.013719188,
0.005621339,
-0.0042168526,
-0.011147689,
-0.010699881,
0.010469193,
-0.0040200884,
-0.0047833966,
-0.008962932,
-0.009811051,
-0.030342339,
0.017844444,
0.039461326,
0.027479086,
0.02688201,
-0.010224934,
0.013685264,
0.006483029,
-0.00013114055,
0.0061743134,
-0.03498325,
-0.012226497,
-0.018902898,
0.022811035,
-0.040845457,
0.043016642,
-0.025837127,
-0.0025087388,
-0.006859594,
-0.009512513,
0.0004969983,
-0.037995774,
-0.022933163,
-0.01336637,
-0.0009431094,
-0.0005623035,
0.017247368,
0.025647147,
0.02184757,
0.0155918375,
-0.011351237,
-0.032703504,
-0.0045798477,
0.0073481114,
-0.008562619,
-0.023001013,
0.024873663,
-0.0048953486,
-0.01511689,
-0.004603595,
0.00011990296,
-0.014492674,
-0.013488499,
-0.014546953,
0.014940481,
-0.024670113,
-0.001279813,
0.008094457,
-0.0051294295,
-0.010462408,
-0.05175567,
0.06046756,
0.0039183144,
0.02708556,
0.0037724376,
-0.004915703,
-0.02509078,
0.02514506,
0.002255999,
-0.012511466,
-0.00070860423,
-0.02836113,
0.007985897,
-0.017993713,
0.0026919327,
0.0009431094,
0.015361149,
-0.03536321,
0.0267056,
-0.010625247,
-0.0009753379,
-0.006788352,
0.016039645,
0.01343422,
-0.03872855,
-0.012959273,
-0.009410739,
-0.009370029,
-0.022254668,
-0.036313105,
0.006734072,
-0.021834001,
-0.014628373,
-0.0033076678,
-0.002374736,
-0.00016114279,
0.0043864762,
-0.004362729,
0.007022433,
0.013590274,
0.002961635,
0.0020168293,
-0.006510169,
-0.009899256,
0.013583489,
-0.015971795,
0.014085576,
0.022105398,
-0.0028615568,
0.007741639,
-0.0037351202,
-0.01842795,
-0.009390384,
-0.0063744695,
0.022770325,
-0.018875757,
-0.005563667,
-0.04668052,
-0.017233798,
-0.002320456,
-0.043098062,
0.016012505,
0.016691001,
-0.0142348455,
0.0016419602,
0.015741106,
-0.17282648,
0.024697253,
0.03226927,
-0.046381984,
0.024670113,
-0.0012077228,
0.019907072,
0.0036537007,
-0.0012849018,
0.0020066518,
0.020490577,
0.0041931053,
-0.017627325,
-0.02857825,
0.018115843,
0.0056315167,
-0.00837264,
0.0401941,
0.0039692014,
0.012484326,
0.03373482,
-0.02865967,
0.017315216,
-0.021169074,
-0.017695175,
0.02529433,
0.012748939,
-0.007979113,
0.00083836657,
-0.02852397,
-0.013149252,
0.00080910645,
0.01508975,
0.0026614005,
-0.004128648,
-0.021711871,
-0.023055293,
-0.007253122,
-0.015306869,
0.017871583,
0.029989522,
0.03384338,
-0.0025409674,
0.007748424,
-0.025972825,
0.014004157,
0.0097635565,
-0.003528179,
0.022783894,
-0.010319924,
-0.001675885,
-0.0043864762,
0.009105416,
0.012457185,
0.012409691,
0.0028089732,
-0.007897693,
-0.0055127796,
-0.014899772,
-0.019201435,
-0.009051136,
-0.0058655976,
0.03528179,
0.010448838,
0.009851761,
-0.026027106,
-0.0119076045,
-0.003796185,
0.0028683417,
0.004165965,
-0.020856965,
0.00158344,
-0.013732758,
-0.01097128,
0.010489548,
0.013888813,
0.0013637769,
-0.006588196,
-0.0033110604,
-0.008121597,
-0.010740591,
0.006123426,
-0.03199787,
-0.027397666,
-0.018957177,
-0.0030701943,
0.014424824,
0.012077228,
0.0008468478,
0.012307917,
0.018645069,
-0.022526067,
-0.002651223,
-0.02524005,
0.01342065,
0.009329319,
-0.009193621,
0.0023034937,
0.0030566242,
-0.00623877,
0.0053465483,
-0.024860092,
-0.004518783,
-0.0017539121,
0.007415961,
-0.006751035,
-0.030640878,
-0.0031651836,
0.026624182,
-0.0086101135,
0.007741639,
0.00935646,
-0.017925864,
0.029582424,
0.0015944655,
0.010984849,
-0.0011067966,
-0.022336086,
0.026976999,
-0.012497895,
0.04866173,
0.001400246,
-0.00071454106,
0.017464487,
-0.01251825,
-0.01251825,
-0.12744868,
-0.045974888,
-0.011636206,
0.023923768,
0.009668567,
0.027926894,
-0.0019710308,
0.00634733,
-0.0200292,
0.020680556,
0.00051099225,
-0.009186835,
-0.005411005,
0.010482763,
0.017763024,
-0.0154289985,
0.02857825,
-0.015971795,
-0.010448838,
0.023150282,
0.021494752,
-0.011615851,
-0.0017259241,
-0.020504149,
-0.0069444063,
0.0049835527,
-0.017980143,
0.006255733,
-0.008060532,
0.0037452977,
0.01169727,
0.0038368946,
-0.0021796683,
-0.007667004,
-0.00589613,
-0.014736933,
-0.0014519814,
-0.019839222,
0.024452994,
-0.005224419,
0.00627948,
0.014126286,
0.017125238,
0.009200405,
0.014506244,
-0.002276354,
-0.014017726,
0.0031414363,
0.0011610762,
-0.008365856,
-0.01700311,
-0.007863768,
-0.015931085,
-0.0007756057,
0.02863253,
-0.015564698,
0.022987444,
0.018604359,
-0.0023781282,
-0.00844049,
-0.003782615,
0.0050887195,
-0.028822508,
0.031645052,
0.0097635565,
-0.012416476,
-0.012898209,
-0.022580346,
0.0066526528,
-0.029935243,
0.0086508235,
0.029311026,
-0.0021576171,
-0.020395588,
-0.011079839,
0.0078027034,
-0.017193088,
-0.03666592,
0.0013239152,
-0.03400622,
-0.008474414,
-0.020802686,
0.010387774,
-0.022892455,
-0.018075133,
-0.0015512113,
0.018726489,
0.010265644,
0.0018115842,
-0.009553223,
-0.010713452,
0.034576155,
0.018346531,
-0.0031651836,
-0.0060080816,
0.022498926,
-0.004074368,
-0.014546953,
0.028171152,
0.0009753379,
-0.0368559,
-0.010414913,
-0.054632496,
-0.0002991743,
0.005139607,
-0.011493722,
-0.011425872,
-0.02358452,
0.014831922,
-0.012592885,
0.0027886184,
0.014180565,
-0.03020664,
0.013298521,
-0.0020677163,
-0.002439193,
-0.03400622,
-0.019771373,
0.027546937,
0.00022941644,
0.049584486,
0.028415412,
0.009729632,
0.024303725,
-0.009668567,
-0.0073345415,
-0.0016869106,
0.0007650042,
0.0025121314,
0.02172544,
-0.014424824,
0.001916751,
0.0044305786,
-0.031129396,
-0.008501555,
0.0132442415,
-0.025769277,
-0.0068528093,
-0.011961884,
0.033273444,
0.0063880393,
0.0061132484,
0.016093925,
-0.010102805,
0.02017847,
0.0015902249,
0.00292771,
-0.00007670185,
-0.028415412,
-0.0057502533,
0.009193621,
0.0023798246,
0.011045914,
0.00013760747,
0.0075855847,
-0.0122739915,
0.004355944,
0.011235893,
0.0030226996,
0.0036944104,
-0.031156534,
-0.010462408,
0.026325643,
0.0022169854,
0.0061573507,
-0.029745262,
0.016365323,
-0.024710823,
-0.019472834,
0.004342374,
-0.0018302428,
-0.041578233,
-0.034413315,
0.0068765567,
0.037534397,
0.0032991867,
0.008121597,
0.0007857831,
-0.01347493,
0.0068765567,
-0.0065407013,
0.02692272,
-0.0006907937,
-0.019174296,
-0.04526925,
0.0032822243,
0.006554271,
0.013122112,
-0.012579315,
0.0060962862,
0.008901867,
-0.0035315715,
0.018156553,
0.019459264,
0.010760946,
-0.012382551,
0.0144791035,
0.010570967,
0.0050514024,
0.009410739,
0.009444664,
0.018387241,
0.011866895,
0.0053465483,
-0.015944656,
0.0054551074,
-0.013210316,
-0.0012560657,
0.011568356,
-0.030125221,
-0.01169727,
0.022892455,
0.029501004,
0.016528161,
-0.008108026,
-0.0011508988,
0.0036299534,
0.02692272,
-0.024127316,
0.0023153676,
-0.008800092,
0.01875363,
0.003421316,
0.021630451,
0.0044509335,
0.014859062,
-0.003175361,
0.024059467,
0.013617414,
-0.023001013,
0.008827233,
0.0085286945,
0.021698302,
0.010489548,
-0.021440472,
-0.014967621,
-0.018387241,
0.0055467044,
0.00092953944,
-0.007558445,
-0.0048037516,
0.07995396,
0.0073277564,
-0.0007446493,
0.0004221517,
0.013339231,
0.016053215,
0.008840802,
0.015523988,
-0.01997492,
-0.009478589,
0.014085576,
-0.03395194,
0.013671693,
-0.024900801,
-0.021630451,
0.020571997,
-0.010292783,
0.019567823,
0.006150566,
-0.03693732,
0.010760946,
-0.012959273,
-0.008705103,
-0.011005204,
-0.02359809,
0.004165965,
0.03235069,
-0.02172544,
0.025755707,
-0.020816255,
-0.011466581,
0.023326691,
-0.03332772,
-0.00759237,
0.034060497,
-0.026271364,
0.0045628855,
-0.014831922,
0.014343404,
-0.011113764,
-0.022376796,
-0.009811051,
-0.007877338,
-0.008725458,
0.0077687786,
0.008996856,
-0.009994245,
-0.023353832,
-0.01507618
] |
The use of retrogenic mice offers a rapid and flexible approach to T cell receptor (TCR)-transgenic mice. By transducing bone marrow progenitor cells with a retrovirus that encodes a given TCR-α/β subunit, TCR-retrogenic mice can be generated in as few as 4–6 weeks, whereas conventional TCR transgenics can take 6 months or longer. In this updated protocol, we have increased the efficiency of the bone marrow transduction and bone marrow reconstitution compared with our previously published protocol. The main departure from the previous protocol is the implementation of spin transduction | [
-0.03953157,
-0.011694979,
-0.008492066,
-0.027789785,
0.0023854682,
-0.0076629193,
-0.014510065,
-0.0069140126,
-0.04571005,
-0.0031945547,
-0.00033955727,
0.014041998,
-0.004286153,
-0.014215852,
0.0050049694,
0.015192105,
0.021276971,
0.018227851,
-0.00037633392,
0.012403766,
-0.03455669,
0.003227988,
-0.016395705,
-0.0069140126,
0.0020093431,
0.007836773,
0.014309465,
-0.026265224,
-0.015633425,
-0.008244659,
0.017933639,
0.0067535327,
0.0006582187,
-0.009795966,
-0.021932265,
-0.031694796,
0.014670545,
-0.0051253294,
0.024366211,
0.00041624496,
0.036295224,
0.030731916,
0.0026077998,
0.022641052,
0.0084987525,
-0.0122633455,
-0.010531499,
-0.018321466,
-0.003784653,
0.0007087866,
-0.002184868,
0.010317526,
-0.011587992,
0.011273719,
-0.024580184,
0.0018120866,
0.0072951526,
0.02625185,
0.014162359,
-0.037338343,
-0.010618426,
-0.0024423047,
-0.021263598,
0.0062587196,
-0.0044299164,
0.009381392,
0.006893953,
-0.015044998,
-0.0083449595,
-0.009642173,
0.027896771,
0.0038314597,
-0.0004024537,
-0.021811904,
0.022092745,
0.0061818226,
0.0013097507,
0.0045970827,
0.008772906,
0.012377019,
0.014269345,
-0.021745037,
-0.013854772,
0.027040878,
0.0077431593,
0.016221851,
-0.0046137995,
0.004289496,
0.0071948525,
0.0032162864,
-0.005439603,
0.03832797,
0.017077746,
0.025382584,
-0.013112552,
0.008318213,
0.001528739,
0.032604184,
-0.016435824,
-0.01773304,
-0.017759785,
0.0061684493,
-0.020956011,
-0.025382584,
-0.029260851,
0.006445946,
0.02733509,
-0.016101493,
0.00794376,
-0.026987385,
-0.028511943,
0.055419087,
-0.0042694365,
-0.03664293,
0.040708423,
0.018254599,
0.0098026525,
0.0031143147,
0.015566559,
-0.016850399,
0.03894314,
0.006830429,
0.022788158,
-0.013239599,
0.022734664,
0.0129587585,
-0.015232225,
0.016823651,
-0.010424512,
0.0056067696,
0.007569306,
-0.03142733,
0.0014652157,
0.042125996,
-0.014817652,
0.013734412,
0.00041373746,
0.0112670325,
-0.011949073,
-0.03118661,
-0.0028401613,
0.02548957,
0.009381392,
-0.006502783,
-0.011327213,
-0.0019792533,
-0.0016206807,
-0.009214226,
-0.001257929,
-0.010177106,
-0.015459572,
0.00097040244,
0.012764846,
-0.0141088655,
0.008338273,
0.0034804097,
-0.007428886,
0.016154986,
-0.018762784,
0.0066432026,
0.010645173,
-0.009287779,
0.024981385,
0.021210104,
0.021022879,
0.020166986,
0.006987566,
0.009020313,
0.017840026,
-0.022306718,
-0.006328929,
0.013854772,
-0.002711443,
0.024071997,
-0.025288971,
0.010845772,
-0.023095744,
-0.0012437198,
-0.015914265,
-0.014510065,
-0.011989192,
-0.003764593,
0.0067200996,
0.014148985,
-0.009729099,
-0.005499783,
0.005463006,
-0.017505692,
-0.009535186,
-0.004506813,
0.0012445557,
0.009040372,
0.027789785,
-0.024112118,
-0.6372125,
-0.004720786,
0.021330465,
-0.014296092,
0.020207105,
0.017104492,
0.026719918,
-0.007067806,
-0.02877941,
0.018308092,
0.013507065,
0.0035272164,
0.03362056,
-0.03150757,
-0.038140744,
-0.026626304,
-0.004647233,
0.017679544,
0.009541873,
0.002475738,
-0.031079624,
-0.012504065,
-0.016529439,
0.023443451,
0.004951476,
-0.01713124,
0.018869773,
0.0154194515,
-0.005690353,
0.036268476,
-0.0046840096,
0.013426825,
-0.010564933,
-0.036108,
0.036589436,
0.017064372,
-0.017157985,
0.0076361727,
0.006796996,
0.051433835,
-0.024540065,
0.006265406,
0.029849278,
0.00024448123,
-0.030116744,
0.015753785,
-0.018094119,
-0.010043372,
-0.001017209,
-0.010598366,
0.020982757,
0.016663171,
-0.011006252,
-0.009762532,
-0.0045101563,
-0.009909639,
0.02240033,
-0.0038013696,
0.021089746,
-0.028993385,
-0.013145985,
0.0039585065,
-0.008920013,
-0.008044059,
-0.014162359,
-0.006987566,
0.0024657082,
0.008157733,
0.029795785,
-0.013600679,
0.030089997,
0.0102640325,
-0.016703293,
0.0052189426,
0.0020327466,
0.016984131,
-0.008492066,
-0.019123865,
0.013567246,
0.012691292,
-0.0060581192,
0.0019809247,
-0.015793905,
0.009495066,
0.021290345,
-0.006980879,
-0.031534318,
0.0067200996,
0.0053961393,
0.021250226,
0.006512813,
0.010598366,
-0.004115643,
-0.03367405,
-0.03535909,
-0.0026546065,
0.014483319,
0.025837278,
0.004299526,
-0.014135612,
-0.007181479,
-0.011320526,
0.037873276,
-0.0030808814,
0.011949073,
-0.008411826,
-0.04659269,
0.010798966,
0.033888023,
-0.021089746,
-0.000791952,
-0.012972132,
0.00032451225,
0.004025373,
-0.020728664,
-0.017171359,
0.0019642082,
0.015085119,
-0.003473723,
-0.017759785,
0.024754038,
-0.005964506,
0.0075158128,
0.012283405,
0.0100366855,
0.017211478,
0.0018990132,
-0.013540499,
0.0121162385,
-0.0088798925,
0.0063322727,
-0.015218852,
0.003358378,
-0.027348464,
0.02966205,
0.0025860681,
0.026532691,
0.009287779,
-0.0037177864,
-0.036108,
-0.019511692,
0.006743503,
-0.0033366464,
-0.001247899,
0.009602052,
-0.0053292727,
0.0006912341,
-0.013734412,
0.012584305,
-0.019725665,
-0.007682979,
-0.023175985,
0.014041998,
0.0015228882,
0.019337839,
-0.009154046,
-0.028939892,
-0.039986264,
-0.0023787816,
-0.020528065,
-0.0010514782,
0.017813278,
0.009434886,
0.012002566,
-0.009695666,
-0.016141612,
0.011173419,
0.01947157,
-0.027268223,
-0.027575811,
0.0031627931,
-0.023389958,
-0.028672423,
0.007970506,
-0.0030959265,
0.003724473,
-0.012303466,
-0.012423825,
-0.017933639,
-0.01681028,
-0.007983879,
-0.00098294,
0.0072082262,
-0.000023181314,
0.029902771,
0.00948838,
0.0064593195,
0.018615678,
0.002591083,
0.042152744,
-0.024031878,
0.012236599,
-0.009475006,
0.018134238,
0.012657858,
-0.014938012,
0.008311526,
0.024272598,
-0.0017569215,
0.018374959,
0.012965445,
-0.019217478,
0.012350272,
-0.043730795,
0.014215852,
-0.02179853,
0.010939386,
-0.016663171,
0.014389705,
0.027763037,
-0.006927386,
0.011688292,
0.011534499,
-0.0042627496,
0.014697292,
0.020942638,
-0.0075158128,
0.0022266598,
-0.0043630498,
-0.020166986,
-0.012156359,
0.006496096,
0.013734412,
-0.017371958,
-0.0009904624,
0.009949759,
0.002372095,
0.009943073,
0.017064372,
-0.024459824,
-0.014924639,
0.009127299,
-0.0050417464,
0.009267719,
0.025543064,
0.0018822965,
0.004055463,
0.0069541326,
0.001197749,
0.02813749,
0.010237286,
0.018789532,
-0.0016047999,
-0.009314526,
-0.00068914454,
-0.010892579,
0.013694292,
-0.00037737872,
-0.0151118655,
0.0030558065,
-0.024633678,
0.013567246,
-0.017987132,
0.015299092,
0.0055566197,
0.0014710665,
0.015767159,
0.015098492,
0.031159865,
0.033406585,
0.011554559,
0.0070744925,
0.0052490328,
-0.038140744,
0.004817743,
0.02749557,
-0.0033299597,
-0.010304152,
0.010551559,
0.0041290163,
-0.02320273,
-0.0016574573,
0.011240286,
-0.030116744,
0.013293092,
0.006425886,
0.025636679,
0.002550963,
0.024861025,
-0.010270719,
-0.022092745,
-0.036535945,
0.018267972,
0.0030307313,
-0.012684605,
-0.014095492,
-0.013065745,
-0.027348464,
-0.0072550327,
0.0022433766,
0.017425451,
-0.00023904831,
0.027789785,
0.00033955727,
-0.0076762927,
-0.023416705,
0.04857194,
-0.0016917265,
-0.00051905244,
-0.010832399,
0.02500813,
0.0352521,
0.00031678082,
-0.021049624,
0.03046445,
0.004837803,
-0.010157046,
-0.03423573,
-0.0057471893,
-0.020474572,
0.004276123,
-0.016048,
-0.0027749664,
-0.027281597,
-0.006693353,
0.009207539,
-0.009368019,
-0.0015680232,
0.006599739,
-0.020033251,
-0.009675606,
-0.008558933,
-0.015406079,
-0.004125673,
0.014991505,
0.015860772,
-0.0017987131,
0.008458633,
-0.020434452,
0.012624426,
0.0011852116,
-0.03503813,
0.034904398,
-0.024379585,
-0.01003,
0.02853869,
0.0032547347,
-0.003894983,
0.011902265,
0.030223731,
0.0028083997,
-0.028725917,
0.014429825,
-0.016288718,
0.009220912,
0.012082806,
0.028003758,
0.021397332,
0.026719918,
-0.012811652,
0.03311237,
0.025864024,
0.003388468,
-0.023603931,
0.004496783,
-0.0073620193,
-0.009461633,
0.017358584,
0.017117865,
-0.029608557,
0.013787906,
0.021584557,
-0.0014869474,
0.010678606,
0.021343838,
0.046726424,
0.013406766,
0.006786966,
0.0125709325,
0.0017335182,
0.006676636,
-0.0035673364,
0.005964506,
-0.042366717,
0.015352585,
-0.015860772,
-0.030116744,
0.014978132,
-0.010518125,
0.018388331,
-0.0019207448,
-0.026064625,
-0.0023637365,
0.020407705,
0.0043663927,
-0.03535909,
-0.0121897925,
0.0062921527,
-0.0069541326,
-0.034289222,
0.0034503196,
0.0026178297,
-0.032176238,
-0.017933639,
-0.00101303,
0.0022082715,
-0.00004727682,
0.015044998,
0.00405212,
0.010170419,
0.019003505,
0.0062787794,
-0.006215256,
0.043516822,
-0.014028626,
-0.014389705,
0.010919326,
-0.03078541,
-0.0007961312,
0.0037478763,
0.0054797227,
-0.009408139,
-0.020407705,
-0.0027983699,
0.0011049715,
-0.004790996,
0.005860863,
-0.013366645,
-0.023884771,
-0.006526186,
0.010297466,
0.020046625,
-0.017010879,
-0.012845086,
-0.017157985,
0.0006803683,
-0.017064372,
-0.008853146,
-0.014082119,
-0.0056803226,
-0.003774623,
-0.011634799,
-0.024874398,
-0.02669317,
-0.0045502763,
-0.008077493,
0.008966819,
-0.009321213,
0.041591063,
0.022065997,
0.0084987525,
-0.00075601117,
0.030250477,
0.0066666063,
-0.006716756,
-0.031213358,
0.023523692,
-0.0036876963,
-0.015165359,
0.006034716,
-0.0032213014,
-0.006405826,
-0.0166498,
-0.006512813,
-0.011440885,
0.030223731,
0.0023620648,
-0.020501317,
-0.015165359,
-0.020621678,
0.0006289645,
0.011694979,
0.016582932,
-0.02195901,
-0.027201358,
0.027709544,
0.003132703,
-0.00079236994,
0.019591931,
-0.031561065,
-0.008284779,
0.021517692,
0.009769219,
-0.008010626,
-0.0022199731,
0.004516843,
-0.021544438,
-0.028057251,
-0.013079119,
-0.022681171,
0.011307152,
-0.03696389,
0.03559981,
0.03311237,
0.042232983,
-0.008692666,
0.0042393464,
0.007368706,
0.010919326,
0.024392959,
0.017920265,
0.03046445,
-0.012069432,
0.004797683,
-0.0034402898,
0.0041423896,
0.005038403,
-0.037579063,
0.013119238,
0.021504318,
-0.012330213,
-0.015352585,
0.018522065,
-0.03696389,
-0.028886398,
0.011273719,
0.005603426,
-0.0019575215,
-0.008097553,
-0.009294466,
0.043490075,
0.008612426,
0.010558246,
0.032818157,
0.034663677,
-0.0061684493,
0.0068203993,
-0.022092745,
0.00026704872,
0.0013716024,
0.005580023,
-0.028083997,
-0.013192792,
0.021838652,
0.0036308598,
-0.015927639,
-0.0007835937,
0.0043028696,
0.021932265,
0.00019871935,
-0.02412549,
-0.026278598,
-0.02304225,
-0.005442946,
-0.012791593,
-0.033567064,
-0.0012963774,
-0.011073119,
0.0047408463,
0.021571185,
-0.022172986,
0.025797158,
-0.006980879,
-0.029635305,
0.021450825,
-0.009528499,
0.04242021,
-0.026505943,
0.009368019,
0.021972384,
0.0112670325,
-0.021878771,
-0.043998264,
0.009996566,
-0.00093195407,
0.026332092,
0.027736291,
-0.0055967397,
-0.013707666,
-0.0020578215,
-0.0034703796,
-0.038194235,
-0.041644555,
0.03102613,
-0.006893953,
-0.020407705,
-0.014978132,
-0.013373332,
-0.014296092,
0.007642859,
-0.008251346,
0.016114864,
0.011240286,
0.0030006415,
-0.021905517,
0.056061007,
-0.0030390897,
-0.003067508,
0.0077431593,
-0.023269597,
-0.0035272164,
-0.017438825,
-0.023109118,
-0.015218852,
0.0017402049,
0.03608125,
0.027241478,
-0.014764159,
0.015379332,
-0.009555246,
-0.015165359,
-0.014362958,
-0.0056368597,
0.041484077,
-0.006907326,
0.008692666,
0.0014451557,
0.021597931,
-0.0059110126,
-0.007937073,
-0.014122238,
-0.0062921527,
-0.013319839,
0.0030624932,
0.032042503,
0.017010879,
-0.017425451,
-0.010966132,
-0.013406766,
-0.018054,
-0.024660425,
-0.009013626,
0.025743665,
-0.032577436,
0.033005383,
-0.010839086,
0.016261972,
0.007970506,
-0.0077565326,
0.02207937,
0.0064091696,
0.023430077,
-0.03632197,
0.029421331,
0.021811904,
0.027281597,
-0.0054864096,
0.0030741948,
-0.006639859,
-0.031052878,
-0.0034302596,
-0.0057271295,
-0.031213358,
-0.007288466,
-0.0087327855,
-0.008665919,
-0.006853833,
-0.012992192,
0.016596304,
0.009856146,
0.029688798,
-0.0031711513,
-0.029394584,
0.015834026,
-0.016007878,
0.0035405897,
-0.013380019,
-0.012985505,
-0.0057505327,
-0.0069006393,
-0.020327466,
0.0083449595,
0.004225973,
-0.0037478763,
0.0019006848,
0.014657172,
-0.017077746,
0.0023503632,
-0.022801531,
-0.004506813,
-0.016783532,
0.024606932,
0.0076963524,
-0.036749918,
-0.010839086,
0.013339899,
-0.010197165,
0.011788593,
-0.009789279,
0.011527812,
0.0071346727,
-0.0066097695,
-0.03094589,
-0.022868399,
-0.02240033,
0.031347092,
0.017826652,
-0.008605739,
-0.016449198,
0.0012069432,
-0.03961181,
-0.033326343,
0.03784653,
0.012310152,
0.010284092,
0.019605305,
0.010972819,
-0.011949073,
-0.030517943,
0.018923266,
-0.007435573,
-0.0014510065,
0.010444572,
0.0055599627,
0.006927386,
0.030838903,
-0.04793002,
-0.005142046,
0.05060469,
-0.006191853,
-0.0060948962,
0.016114864,
-0.0001924506,
0.046940397,
-0.022440452,
-0.0019892831,
-0.0025476199,
0.0067702495,
0.0088798925,
-0.022667797,
-0.0023269597,
0.033058878,
-0.018174358,
-0.018682545,
-0.020835651,
-0.0049414462,
0.016890518,
-0.0043897964,
-0.0056803226,
-0.013680919,
0.010712039,
-0.019926265,
0.0048946394,
0.016261972,
0.0058675497,
-0.0072015394,
0.0057271295,
-0.012825025,
0.00037716975,
0.002555978,
-0.0001278825,
-0.011634799,
-0.023697544,
-0.011139986,
0.00848538,
0.014643799,
0.005262406,
-0.016261972,
-0.013426825,
-0.0013306466,
-0.004526873,
-0.022453824,
0.022226479,
0.018923266,
-0.028993385,
-0.020100119,
0.005539903,
-0.021544438,
-0.014376332,
-0.005670293,
-0.0076227994,
-0.013975132,
-0.0062286295,
-0.009675606,
0.004600426,
-0.004025373,
-0.0027766381,
0.009535186,
-0.00035606496,
0.013948386,
0.18497993,
-0.02320273,
0.0029538348,
0.020514691,
-0.00046179787,
-0.0038113997,
0.009220912,
0.010103553,
-0.0019224165,
0.018254599,
0.02207937,
0.012771532,
-0.014001879,
-0.010043372,
0.0043329597,
-0.020193731,
-0.010023313,
-0.020260599,
-0.030598184,
-0.010076806,
0.0013548858,
0.006867206,
-0.0015462915,
-0.018040625,
0.021611305,
0.0088798925,
-0.02593089,
0.0051754797,
0.0031310313,
0.014911265,
-0.049882527,
0.005673636,
0.0024673797,
0.009869519,
-0.0057572196,
0.010832399,
-0.0044065127,
-0.011106553,
-0.013413453,
0.003594083,
-0.007896952,
0.021210104,
0.0029956263,
-0.0014861115,
-0.0073352726,
0.031373836,
0.0026897115,
0.0068203993,
0.0009394766,
-0.021210104,
-0.02256081,
0.016823651,
0.009929699,
-0.0032998696,
0.013092492,
-0.0030006415,
0.0028134147,
0.014911265,
0.017345212,
0.023657424,
-0.017906891,
0.0064426027,
-0.02853869,
0.018829651,
-0.028404957,
0.031694796,
0.0067501892,
0.006496096,
0.041403838,
-0.021597931,
-0.019190732,
0.002731503,
-0.009434886,
0.0057204426,
-0.009073806,
-0.017305091,
0.023563812,
0.020782158,
0.024901144,
-0.012517439,
0.0028384898,
0.004506813,
-0.022748038,
0.008371706,
0.0017168015,
-0.015927639,
0.019110491,
0.0019341181,
-0.0067200996,
0.018174358,
0.017947013,
0.00059218786,
0.0016858757,
-0.010090179,
-0.014322839,
0.0078835795,
0.008833086,
0.0087260995,
0.014015252,
-0.015954385,
-0.04458669,
0.059056636,
0.027736291,
-0.018281344,
-0.0021865398,
0.03592077,
-0.020260599,
0.002089583,
0.017652798,
-0.015272345,
0.0060480894,
-0.006512813,
0.017318465,
-0.012778219,
-0.0003038254,
0.018094119,
0.0058140564,
-0.039157115,
0.014951386,
0.02721473,
0.018936638,
-0.018936638,
-0.009675606,
0.016449198,
-0.009561933,
-0.008512126,
0.0050551197,
-0.003543933,
-0.024954638,
-0.027575811,
-0.0135003785,
-0.0044700364,
0.0007284287,
0.013801279,
0.005111956,
-0.0098026525,
0.0089601325,
0.004627173,
-0.028003758,
0.006242003,
0.0075759925,
-0.0070811794,
0.024927892,
-0.0046739797,
0.0043597063,
-0.015192105,
0.012831712,
0.018054,
-0.023095744,
-0.0026395614,
-0.0039284164,
-0.020648425,
0.001082404,
-0.024446452,
0.011788593,
-0.016863773,
-0.014443199,
-0.04105613,
-0.007549246,
0.02163805,
-0.029528318,
0.006155076,
0.006927386,
0.0016290391,
-0.010136986,
-0.0068404595,
-0.16829,
-0.00012986759,
0.04065493,
-0.023898145,
0.015941013,
0.010631799,
0.012898579,
-0.0033399898,
-0.010457946,
0.015004879,
0.03174829,
0.035733543,
-0.034128744,
-0.017144611,
-0.0011927341,
-0.0102640325,
-0.05442946,
0.03985253,
0.0028000413,
0.007435573,
0.022895144,
-0.042848155,
0.019698918,
-0.013453572,
0.0001709279,
-0.0013356615,
0.021089746,
-0.02673329,
-0.0008504603,
-0.039504822,
-0.023951638,
-0.006552933,
0.02597101,
-0.028645677,
0.0042393464,
-0.0073352726,
-0.0060547763,
0.00956862,
0.014148985,
0.039183863,
0.025222104,
0.018695919,
0.0075158128,
-0.009495066,
-0.016114864,
0.03832797,
0.006151733,
-0.009755846,
0.007930386,
0.00024531706,
0.0023587216,
-0.008351646,
0.00020112238,
0.021557812,
0.04266093,
-0.0007944595,
0.025181985,
0.0077966526,
0.016529439,
0.0141891055,
-0.011708353,
0.000059709837,
0.04480066,
-0.022346837,
0.012096179,
-0.037873276,
-0.017679544,
0.011367332,
0.0055465894,
0.0060948962,
-0.030999383,
0.004225973,
-0.007836773,
-0.015753785,
0.022493945,
0.021611305,
-0.008819712,
-0.014255972,
0.038755916,
-0.011801966,
-0.0033266165,
0.028592184,
-0.014590305,
0.0037512197,
-0.016689919,
0.00062645704,
0.020635052,
0.03230997,
-0.003187868,
0.012356959,
-0.007870206,
-0.030892396,
-0.00030298956,
-0.032844905,
0.022734664,
0.0060146563,
-0.0015571574,
-0.012270032,
0.010397766,
-0.020648425,
0.029260851,
-0.00886652,
-0.012002566,
0.00840514,
0.019230852,
-0.023122491,
-0.019230852,
0.0057438463,
0.012249973,
-0.005740503,
0.0021129865,
0.015927639,
0.010183793,
0.02717461,
-0.0016056357,
0.011012939,
-0.0034369463,
0.009702353,
0.015914265,
-0.012704666,
0.04442621,
0.0023988415,
0.0043597063,
0.02717461,
0.00049815665,
-0.005590053,
-0.1387617,
-0.014951386,
0.000496485,
0.015793905,
-0.02163805,
0.023844652,
-0.008331586,
0.010919326,
-0.027027505,
0.008893266,
-0.015941013,
-0.018615678,
-0.0073753926,
-0.017238226,
0.005499783,
-0.012891892,
0.025529692,
-0.0047943396,
-0.022814905,
0.039344344,
-0.0027131147,
-0.015392705,
-0.006907326,
-0.0043496764,
-0.0074623195,
0.00044717078,
-0.039959516,
0.012142985,
0.013159359,
0.02488777,
0.016114864,
-0.0070343725,
0.017545812,
-0.013099179,
-0.029876024,
0.0026596214,
-0.016261972,
-0.022761412,
0.02869917,
-0.018120864,
-0.0034469764,
0.010197165,
-0.014536812,
-0.0028735946,
0.0062453463,
-0.010150359,
-0.008605739,
0.0013448558,
-0.007823399,
-0.029528318,
-0.015914265,
-0.015285718,
-0.004988253,
-0.016101493,
0.015058372,
-0.019993132,
0.011240286,
-0.0038481762,
-0.007087866,
-0.014456572,
0.0115746185,
-0.006034716,
-0.031480823,
0.016703293,
0.028752664,
-0.028057251,
0.017639425,
-0.0154194515,
0.017331839,
-0.028378211,
-0.007890266,
-0.004436603,
-0.009521812,
-0.007228286,
-0.023550438,
-0.0002887804,
-0.00013341989,
-0.0059511326,
0.017532438,
-0.0059477896,
-0.017345212,
-0.01897676,
0.008819712,
-0.011414139,
0.019404706,
0.016730038,
0.013466946,
0.006766906,
0.015553186,
-0.015994506,
-0.0063790795,
0.021343838,
-0.028190983,
-0.013273032,
-0.0063790795,
0.019364584,
-0.015138612,
0.0033767663,
0.04137709,
0.023349838,
-0.024901144,
-0.015232225,
-0.05798677,
0.018388331,
0.00021094341,
-0.010946073,
0.024071997,
-0.02629197,
0.0071346727,
-0.02087577,
-0.008003939,
-0.022226479,
-0.020247225,
-0.017973758,
-0.03030397,
0.019190732,
-0.008451946,
0.005349333,
0.034931142,
-0.016275344,
0.034529943,
0.016903892,
0.009642173,
-0.0007643695,
0.010986192,
0.01636896,
0.0010539858,
0.0063255862,
0.0035405897,
0.02629197,
-0.018642426,
-0.012691292,
0.0029588498,
-0.031668052,
-0.0051320163,
0.0059377593,
0.008117612,
0.006676636,
0.016743412,
0.020207105,
0.015446198,
0.026171612,
-0.011561246,
-0.028271224,
0.014951386,
0.003925073,
-0.0024840964,
-0.0056970394,
-0.025529692,
-0.0032213014,
-0.005399483,
-0.0029889396,
0.025288971,
-0.0026011132,
0.008772906,
-0.021330465,
-0.018562185,
0.00013373332,
-0.007549246,
-0.017947013,
-0.014443199,
-0.011119925,
0.024606932,
0.035867278,
-0.010732099,
0.00019286852,
0.0065161563,
-0.039344344,
-0.031668052,
0.010712039,
0.0093412725,
-0.020421078,
-0.012738099,
0.043730795,
0.015232225,
0.01913724,
-0.024647051,
0.005008313,
-0.010223912,
0.015365958,
-0.0062921527,
0.014697292,
0.0084185125,
-0.018147612,
-0.005168793,
0.010785593,
0.02424585,
0.03642896,
0.0064024827,
0.018950012,
-0.011768532,
0.004336303,
0.006081523,
0.022748038,
0.010605052,
0.02705425,
0.0000053839417,
0.042366717,
0.006927386,
0.032363463,
0.013400079,
0.043169115,
-0.0045135,
-0.0054663494,
0.0023236165,
-0.035947517,
0.0014660516,
0.013734412,
-0.043490075,
-0.03816749,
-0.019872772,
0.00040475227,
-0.002109643,
-0.0013874832,
-0.001679189,
0.016154986,
-0.02721473,
-0.00061517325,
-0.015954385,
-0.036108,
-0.017171359,
0.044025008,
0.010050059,
0.018722665,
-0.0025275599,
-0.0010514782,
0.0060614627,
-0.0009252674,
0.027107744,
-0.017492319,
0.005890953,
-0.006830429,
0.004065493,
-0.0013356615,
-0.029849278,
-0.015165359,
-0.009862833,
-0.00063648704,
-0.000012687688,
-0.00039911037,
-0.014831025,
0.0777793,
0.020822277,
-0.009923012,
-0.00071045826,
-0.032122742,
0.03776629,
0.023028878,
0.020421078,
-0.0121897925,
-0.015767159,
0.027241478,
-0.018642426,
0.029849278,
-0.03375429,
-0.037579063,
0.016542811,
-0.003694383,
0.009120612,
-0.007682979,
-0.012417139,
0.014376332,
-0.027080998,
0.011440885,
0.009742472,
-0.034690425,
-0.015860772,
0.016877145,
-0.0071948525,
0.0034152146,
-0.015192105,
0.0032146147,
-0.0035272164,
-0.031561065,
0.010143672,
-0.004329616,
-0.004155763,
-0.017077746,
-0.007047746,
-0.0019842682,
0.025355838,
0.0043429895,
-0.008298152,
-0.016101493,
-0.01947157,
-0.014737412,
-0.015994506,
-0.015954385,
0.0034302596,
-0.005078523
] |
Telomere extension has been proposed as a means to improve cell culture and tissue engineering and to treat disease. However, telomere extension by nonviral, nonintegrating methods remains inefficient. Here we report that delivery of modified mRNA encoding TERT to human fibroblasts and myoblasts increases telomerase activity transiently (24-48 h) and rapidly extends telomeres, after which telomeres resume shortening. Three successive transfections over a 4 d period extended telomeres up to 0.9 kb in a cell type-specific manner in fibroblasts and myoblasts | [
-0.046094377,
-0.013857487,
-0.012020872,
-0.025924772,
-0.0109334905,
0.011543485,
-0.021217205,
0.011377726,
-0.02710498,
0.004687676,
-0.004883272,
0.023232838,
0.016814634,
0.003752793,
-0.0009779806,
-0.00950796,
0.025792165,
0.014891826,
-0.0018150655,
-0.0058214706,
-0.00090504636,
0.0014479085,
-0.017822452,
-0.000032426684,
-0.009965456,
0.017132893,
0.026826503,
-0.040073995,
-0.014865304,
-0.008732206,
0.009766544,
0.009401874,
-0.012637498,
-0.013724879,
-0.027927145,
-0.01656268,
0.014600089,
-0.014905086,
0.024731304,
-0.008380796,
0.025354559,
0.0005872027,
0.002013977,
-0.0022112306,
-0.011881635,
-0.0021714482,
0.017398108,
-0.026163464,
-0.013227601,
0.018724183,
0.019586131,
0.0032969546,
-0.015395734,
0.027051935,
-0.029306265,
-0.007121024,
-0.007445913,
0.011855113,
-0.00055032125,
-0.000963891,
-0.011881635,
-0.004561699,
-0.033496663,
0.00546343,
-0.011410878,
0.021800678,
-0.0050258255,
-0.0010451131,
0.010243932,
0.004087627,
0.022304587,
0.012902712,
-0.009527851,
-0.010449473,
0.016933981,
-0.027012153,
-0.013313795,
0.01636377,
0.0055429945,
0.011908156,
0.012624237,
-0.0039384435,
-0.0040644207,
0.022225022,
0.0065441816,
0.010807513,
-0.015276387,
-0.010422952,
0.033019274,
-0.007896778,
0.022476977,
0.028988006,
0.009143289,
0.041161377,
-0.013128146,
-0.0017404738,
-0.0027913884,
0.03771358,
-0.008871444,
-0.032037977,
-0.009753284,
-0.015170301,
-0.0010426267,
-0.016522897,
-0.02343175,
0.013963573,
0.0232461,
-0.015912903,
0.014003355,
-0.018299839,
-0.04086964,
0.030154953,
-0.016841156,
-0.026203247,
0.011477182,
0.0037130108,
0.021402854,
-0.008586338,
-0.009753284,
-0.008473621,
0.019625913,
0.026985632,
0.007711128,
-0.0004237225,
0.039225306,
0.015170301,
0.006849179,
0.005300986,
-0.012538042,
0.014003355,
0.014122702,
0.022291325,
0.0053672898,
0.016058771,
-0.03540621,
0.00677956,
-0.015488559,
-0.024545653,
-0.006726517,
-0.056649935,
-0.0060966313,
0.0144674815,
-0.002544407,
0.0003918138,
-0.024253916,
-0.0007836276,
0.008937747,
0.0062093474,
0.02221176,
0.0098991515,
-0.0014014958,
-0.012995537,
0.015210084,
0.013486186,
-0.006056849,
0.018207014,
0.002226149,
0.018074406,
-0.02449261,
-0.002070335,
0.012067285,
-0.020328734,
0.05163737,
0.007558629,
0.009050464,
0.026309334,
-0.014056398,
-0.0040080626,
0.009309049,
-0.0014238734,
-0.0009771517,
0.015302909,
-0.029544957,
0.029306265,
-0.027343672,
0.011390987,
-0.0172655,
0.0103168655,
-0.0053308224,
-0.021097858,
-0.011284901,
0.024466088,
0.016575942,
0.013128146,
-0.031401463,
-0.003058261,
0.009819588,
-0.0057518515,
0.013645315,
-0.012677279,
0.0005548796,
-0.004173822,
0.021787416,
-0.0052214214,
-0.6399109,
-0.03487578,
0.008732206,
-0.0016095239,
0.0034842629,
0.024293698,
0.0017222402,
-0.009309049,
-0.025911512,
0.013777922,
-0.011404247,
0.007903408,
0.018538533,
-0.021946546,
-0.0110395765,
-0.01729202,
-0.0082481885,
-0.007910039,
0.022118935,
0.0073000444,
-0.030950597,
0.0018150655,
0.0034842629,
0.017543975,
0.005175009,
0.001486862,
0.021800678,
-0.003858879,
-0.02253002,
0.039172262,
-0.011689354,
0.017915277,
-0.003560512,
-0.011782179,
0.048746526,
-0.0072470014,
-0.008413948,
0.0058844592,
-0.00016575941,
0.032992754,
-0.0126971705,
0.002360414,
0.009435026,
0.020222647,
-0.026136944,
0.007313305,
0.010204149,
-0.018061146,
0.0039881715,
0.0097996965,
0.008599598,
0.018763965,
-0.024214135,
0.009912413,
-0.0058579375,
0.013486186,
0.023140013,
0.009958825,
0.023842834,
-0.01865788,
-0.018909834,
0.028722791,
-0.008155363,
-0.0025212006,
-0.009640567,
-0.0015407337,
-0.01216011,
0.0044854498,
0.012564563,
0.009885891,
0.003401383,
0.048322182,
0.00094399985,
0.0067729293,
-0.002519543,
0.040206604,
0.0078105833,
-0.0114572905,
-0.0026637537,
0.0074923253,
0.009236114,
-0.015952686,
-0.013645315,
0.0046611545,
0.017040068,
0.019944172,
-0.042832233,
0.031799287,
-0.016774852,
0.011888265,
0.00023289197,
0.008871444,
-0.0024648425,
-0.046943065,
-0.014732696,
0.0049727825,
0.016337248,
0.0004214433,
-0.00087686727,
-0.0111456625,
-0.016933981,
-0.0064148894,
0.0271315,
0.007167437,
0.0010832377,
-0.009295788,
-0.039914865,
0.0102107795,
0.04262006,
-0.019877868,
0.028643226,
-0.006643637,
0.003855564,
-0.0142553095,
-0.024121309,
-0.02112438,
0.023338925,
0.005973969,
-0.006540866,
-0.026985632,
-0.001180207,
-0.021044815,
0.012882821,
0.021654809,
0.029810172,
0.01392379,
-0.007989604,
-0.013764662,
-0.015687471,
-0.017716365,
-0.008413948,
0.011855113,
0.03667924,
-0.023020666,
0.022397412,
0.012266196,
0.024757825,
0.022768712,
0.026839763,
-0.025991075,
-0.005413702,
0.009607416,
0.010548929,
0.0020554166,
0.00033214042,
-0.038747918,
-0.023312403,
-0.001743789,
0.009017312,
-0.008513403,
0.004279908,
0.0115633765,
0.007286784,
0.00072022463,
0.021283507,
-0.0128098875,
-0.01355249,
-0.055005603,
-0.022278065,
-0.02079286,
0.0042202347,
0.008791879,
-0.008745466,
0.03591012,
-0.0073199356,
-0.0044423523,
0.015939426,
0.0043031145,
-0.0052711493,
-0.026455201,
0.011642941,
-0.018233536,
-0.018207014,
-0.01426857,
-0.02251676,
0.01514378,
-0.021376334,
0.000784042,
-0.015422256,
-0.017119631,
-0.012670649,
-0.013486186,
0.0010368251,
-0.001523329,
0.026654113,
0.0073729786,
0.029438872,
0.0058579375,
0.013592272,
0.02482413,
-0.0110462075,
0.002103487,
-0.014719436,
0.020753078,
0.008825031,
-0.016827896,
0.013340318,
-0.012252935,
0.007558629,
0.007240371,
0.020209387,
-0.015130519,
-0.0007293414,
-0.02554021,
0.0058380463,
0.013976834,
-0.0046578394,
-0.015276387,
0.009209593,
0.019307656,
-0.01727876,
0.007280153,
-0.018710922,
-0.0041705067,
-0.01339999,
0.00023537836,
-0.014905086,
-0.01567421,
-0.0049993037,
-0.013446404,
-0.016005728,
-0.009229484,
0.0016302438,
-0.00001131826,
-0.004578275,
0.022954363,
0.0035107844,
0.021097858,
-0.0013700015,
-0.01672181,
-0.01109925,
0.0017819137,
0.020355256,
0.0055927224,
0.025115866,
0.008069168,
0.008002864,
-0.014175745,
0.028404532,
0.014759218,
0.007538738,
0.019281134,
0.004080997,
-0.024598697,
0.005970654,
0.006942004,
0.027343672,
0.006239184,
-0.0062789666,
0.011722505,
-0.010310235,
0.031003641,
-0.0034942084,
0.0058048945,
0.020010475,
-0.009647198,
-0.0008702369,
0.02255654,
0.03437187,
0.033655792,
0.028696269,
0.009554372,
0.009773175,
-0.017583758,
-0.0049794125,
0.0032604877,
0.030075388,
-0.021601766,
-0.01776941,
-0.0067066257,
-0.016350508,
0.002895817,
0.03225015,
-0.03240928,
0.018697662,
0.0042500715,
0.003132853,
0.03540621,
0.012060654,
0.006643637,
-0.009454917,
-0.03240928,
0.048375227,
0.0020902262,
-0.022503497,
-0.0034610564,
-0.025288256,
0.010767731,
0.00091167673,
-0.008891335,
0.004455613,
0.0147724785,
0.019068962,
0.0039185523,
-0.0005581948,
-0.00810895,
0.026322594,
-0.014679654,
0.034981865,
-0.014520524,
0.017026806,
-0.006590594,
-0.0053109317,
-0.02678672,
0.01865788,
0.0007082071,
-0.0055927224,
-0.012120328,
0.00722711,
-0.021442637,
-0.013897269,
-0.015249866,
0.006753038,
-0.014984651,
-0.0055562556,
0.005337453,
0.009773175,
-0.017570497,
0.01672181,
-0.004027954,
0.0019393851,
-0.021005033,
-0.0143613955,
0.00147443,
0.027158022,
0.015236605,
0.017490933,
0.004110833,
0.0040942575,
0.026813243,
0.0042567016,
-0.031613633,
0.0017504194,
-0.041134857,
0.0015357609,
-0.021018293,
0.0061960868,
-0.010993164,
-0.008718945,
0.014308352,
-0.006855809,
-0.033735353,
-0.008175254,
-0.011185445,
0.014905086,
-0.0036533375,
0.040206604,
0.027396716,
0.02819236,
-0.0021167477,
0.013751401,
0.018936355,
0.0011346232,
-0.015223344,
-0.0038356727,
0.012743584,
-0.002580874,
0.011172184,
0.0109401215,
-0.02766193,
0.004929685,
0.0014404493,
0.013446404,
0.010887078,
-0.0033052426,
0.024267178,
0.012000982,
-0.0020603894,
0.0032157325,
-0.001000358,
-0.014984651,
0.00077575404,
-0.008208406,
-0.002494679,
0.022808494,
-0.032197107,
-0.031746242,
-0.018061146,
-0.003911922,
0.0061960868,
-0.0207796,
-0.0009323967,
-0.004962837,
-0.0047340887,
0.006288912,
-0.02449261,
0.005088814,
-0.0027433182,
0.01636377,
-0.024426308,
0.011132402,
0.008195145,
-0.016496377,
0.006587279,
0.0010716346,
-0.02624303,
-0.020938728,
0.025619775,
0.009945565,
0.009143289,
0.013134776,
-0.014944868,
-0.008831661,
0.031454507,
-0.036493592,
-0.0090703545,
-0.0040710513,
-0.027370194,
0.002295768,
-0.00413404,
0.00546343,
-0.010767731,
-0.008394057,
-0.007711128,
0.018525273,
-0.016310725,
0.022583062,
-0.006215978,
-0.024558915,
0.0038887158,
0.009945565,
0.019122006,
0.002184709,
0.007697867,
-0.021800678,
-0.04240789,
-0.015767036,
-0.028722791,
-0.01303532,
-0.013453034,
0.01321434,
0.020686774,
-0.017026806,
-0.005440224,
0.0030118485,
0.015024433,
0.0005872027,
0.012252935,
0.024903694,
0.025911512,
0.00060750823,
0.009017312,
-0.006093316,
-0.00017881296,
-0.0015854888,
-0.016244423,
0.011556746,
-0.006961895,
-0.017398108,
0.0076514543,
0.02642868,
-0.013671836,
-0.033761878,
-0.012949125,
-0.0135325985,
0.02538108,
-0.0075321076,
-0.023816312,
-0.022344368,
-0.03222363,
-0.009222854,
-0.0052744644,
0.001094012,
-0.005393811,
-0.021230465,
0.018207014,
-0.0015548232,
-0.007631563,
0.012405435,
-0.029783651,
-0.0032820364,
0.01515704,
0.02819236,
0.009322309,
-0.00046951353,
0.015037694,
-0.0046014814,
-0.0042765928,
-0.015700731,
-0.008155363,
0.015422256,
-0.0048965327,
0.038084883,
0.022079153,
0.040922683,
-0.018697662,
0.013055211,
-0.009063724,
0.011576638,
0.008413948,
-0.007982973,
0.024598697,
-0.0137381395,
0.03646707,
0.02112438,
-0.00950796,
0.033045795,
-0.019864608,
0.013353578,
0.026375636,
-0.016628984,
-0.018379403,
0.023922399,
-0.028033232,
-0.04179789,
0.009647198,
-0.019480046,
-0.020129822,
-0.0117689185,
-0.014759218,
0.014944868,
0.0155018205,
0.016748331,
0.014865304,
0.004558384,
-0.0011511991,
0.02043482,
-0.015011172,
0.009667089,
-0.012219784,
-0.01567421,
-0.007910039,
-0.008055908,
0.020103302,
0.0074790646,
-0.010310235,
0.010117955,
-0.019678958,
0.0018598206,
0.012531412,
-0.009653828,
-0.04739393,
-0.02079286,
-0.027051935,
0.0071409154,
-0.017809192,
-0.0092758965,
-0.02414783,
-0.009322309,
0.025328038,
-0.018405925,
0.014944868,
-0.006849179,
-0.0032157325,
0.025500428,
-0.021389594,
0.019983955,
-0.009441656,
0.0056988085,
0.029598,
-0.003185896,
-0.035114475,
-0.012624237,
0.014706175,
-0.0007334854,
0.029916259,
0.015355952,
-0.012113698,
-0.03225015,
0.033204924,
0.013134776,
-0.011384356,
-0.033337533,
-0.0118087,
0.0022029425,
-0.011019685,
-0.014865304,
-0.006106577,
-0.038350098,
0.011775549,
-0.006660213,
0.0081354715,
0.024240656,
-0.007677976,
-0.014547046,
0.01971874,
-0.003054946,
0.021044815,
0.0010683194,
-0.02556673,
-0.034928825,
-0.023219578,
-0.012471738,
0.0068160268,
-0.014348134,
0.03540621,
-0.0034809476,
-0.0062557603,
0.033523183,
-0.010237301,
0.018021364,
-0.015249866,
0.005460115,
0.039729215,
-0.024598697,
0.003291982,
0.014016616,
0.02569934,
-0.006620431,
-0.01110588,
-0.009879261,
-0.019427003,
-0.015103998,
-0.0060469033,
0.014162484,
0.035512295,
0.0001130272,
-0.0122860875,
-0.011596528,
-0.008831661,
-0.01478574,
-0.019334178,
0.014799,
-0.039357916,
-0.028457576,
0.0008192659,
0.026919328,
0.030924076,
-0.01603225,
-0.013293904,
-0.010005238,
0.03474317,
-0.025434123,
0.0013766319,
-0.00059880584,
-0.002295768,
-0.020288952,
-0.014348134,
-0.020580688,
-0.035989683,
-0.0017669953,
-0.03593664,
-0.029704086,
-0.00546343,
-0.0034908932,
0.028378012,
-0.0030615763,
-0.03930487,
0.025500428,
-0.005019195,
0.020540906,
-0.005254573,
-0.01670855,
-0.006464617,
-0.0034842629,
0.010376539,
0.0048700115,
-0.016443333,
-0.007081242,
0.007207219,
-0.025778903,
-0.0042567016,
-0.018114189,
-0.02062047,
-0.015408995,
-0.015037694,
-0.027370194,
-0.007147546,
-0.004618057,
-0.0221985,
-0.023537837,
-0.0010898681,
-0.018100929,
0.011225227,
-0.03278058,
0.022702409,
-0.0020454712,
0.022410672,
-0.019427003,
0.008493512,
-0.021243727,
-0.006882331,
-0.014016616,
-0.0026405475,
-0.0026438625,
0.029677564,
0.0007848708,
-0.012120328,
-0.011059468,
-0.009912413,
-0.07585151,
-0.028590184,
0.021416117,
0.015488559,
-0.001307013,
0.0018863421,
-0.007240371,
-0.001813408,
-0.008148733,
0.015899643,
-0.0066635283,
-0.020766338,
0.006975156,
-0.018352881,
0.0162179,
0.013234232,
-0.042222235,
0.007996234,
0.0349023,
-0.0107345795,
-0.022874799,
0.01989113,
0.00007391834,
0.019983955,
0.009819588,
0.011470552,
-0.0057750577,
0.0114572905,
0.03012843,
-0.048216097,
0.0002519543,
0.008261449,
-0.009023942,
-0.01656268,
0.001307013,
-0.011815331,
0.012591084,
0.012942495,
0.012385543,
-0.022954363,
0.014135962,
-0.023047188,
0.016430072,
0.017119631,
0.0022211762,
0.0017305282,
0.020514384,
-0.025420863,
-0.01884353,
0.017106371,
-0.015475298,
-0.019705478,
0.036493592,
0.0028112796,
-0.0021780788,
0.014825522,
0.0016749988,
-0.0035969792,
-0.0077044973,
-0.0009978716,
-0.021336552,
-0.0155018205,
-0.014547046,
0.010164367,
-0.02221176,
-0.032197107,
0.019082224,
-0.021243727,
-0.0077774315,
-0.0044092005,
-0.013804444,
0.0015001227,
0.0005519788,
0.0026687265,
0.000019321331,
-0.008825031,
-0.0047838166,
0.009720132,
0.001975852,
0.024373263,
0.19668348,
-0.027264107,
-0.017809192,
0.018114189,
0.003144456,
0.0046545244,
0.017106371,
-0.00075296214,
-0.024532393,
-0.01497139,
0.025487168,
-0.0015854888,
-0.0030483156,
-0.010860557,
0.022476977,
-0.02307371,
-0.006590594,
0.016323987,
-0.020540906,
-0.0038489336,
-0.0042036586,
-0.01670855,
-0.006673474,
-0.003573773,
0.008466991,
0.00016234063,
-0.028802356,
0.0017636801,
0.0005014222,
0.012511521,
-0.035140995,
-0.012670649,
0.014242048,
-0.016748331,
-0.0047970773,
0.007121024,
0.015515081,
-0.0020603894,
-0.012975646,
-0.018273318,
0.021018293,
0.0055098427,
-0.01636377,
0.0013094994,
0.018153971,
0.033841442,
-0.0010691482,
-0.013492816,
-0.01092686,
-0.001927782,
-0.03519404,
0.0017537345,
0.0090703545,
0.035883598,
0.020700036,
-0.011662832,
-0.006743093,
0.026534766,
0.026441941,
0.019413741,
-0.010999794,
0.015833339,
-0.024413045,
0.020461341,
-0.03487578,
0.017079849,
-0.009554372,
0.011676093,
0.013512707,
-0.00042724487,
-0.007916669,
0.00097549416,
-0.010263823,
0.016483115,
-0.018697662,
-0.02432022,
0.031109726,
0.0069685257,
0.030950597,
0.0039715953,
0.012909343,
-0.02607064,
-0.030552775,
-0.006162935,
-0.008075799,
-0.028669748,
0.023193056,
0.011066098,
-0.0019078908,
0.0038621943,
0.007147546,
-0.020660253,
-0.008778619,
0.0023123438,
0.003144456,
0.010277083,
0.005413702,
-0.007366348,
0.0025759013,
-0.03031408,
-0.045537423,
0.07118372,
0.006514345,
-0.014242048,
-0.0060369577,
0.012173371,
-0.010721318,
0.015912903,
-0.007061351,
-0.0063088033,
0.01743789,
-0.01761028,
0.015912903,
-0.020925468,
-0.008354275,
0.019732,
0.036228377,
-0.038907047,
0.05458126,
-0.0017471042,
-0.0009265951,
0.007359718,
-0.018366143,
0.019506568,
-0.011477182,
0.016814634,
0.0050125644,
-0.012073915,
-0.025288256,
-0.01478574,
-0.008606229,
0.002237752,
-0.005214791,
-0.010966643,
0.016761592,
-0.0046909912,
0.016483115,
-0.0034378502,
-0.012909343,
0.006643637,
-0.008486882,
-0.02202611,
-0.004929685,
0.008539924,
-0.0183131,
-0.00792993,
0.020341994,
0.031534072,
0.0034245895,
-0.021442637,
-0.017888756,
-0.0044489824,
-0.002368702,
-0.007346457,
0.0066270614,
-0.01303532,
-0.016005728,
-0.023219578,
-0.004561699,
0.0030847825,
-0.027317151,
-0.014520524,
0.011782179,
0.0010045021,
-0.0022410671,
0.009713502,
-0.1669794,
0.0052744644,
0.019373959,
-0.033974048,
0.027927145,
-0.011994351,
0.0020603894,
-0.011430769,
-0.019612653,
0.020660253,
0.021535462,
0.02729063,
-0.036573157,
-0.030977119,
-0.0011238488,
0.0012349077,
0.0016435046,
0.011543485,
0.024360003,
-0.006746408,
0.017199196,
-0.03667924,
0.005901035,
-0.013453034,
0.006322064,
-0.01039643,
0.0067861904,
-0.028245404,
0.004594851,
-0.015992468,
-0.02450587,
0.018167231,
0.012073915,
-0.018140709,
0.033947527,
0.0128032565,
0.0062557603,
0.014520524,
0.0059839147,
0.00826808,
0.024174353,
0.019944172,
-0.0012954097,
0.0025510374,
-0.01725224,
0.01883027,
0.010263823,
-0.0320645,
0.008161994,
-0.01849875,
0.004107518,
-0.03543273,
0.012034133,
0.013830965,
0.020580688,
0.00054369087,
-0.0010799225,
0.009083616,
0.00037979626,
0.0017736257,
-0.003842303,
0.0055396794,
0.026587809,
-0.012305979,
0.0027632094,
-0.030924076,
-0.0037196411,
0.0061927717,
-0.023312403,
0.010714688,
-0.031852327,
-0.003998117,
-0.00024221595,
-0.017835712,
0.010674906,
0.010296974,
-0.020912208,
0.004594851,
-0.011311422,
-0.0077973227,
-0.022662627,
0.030526252,
-0.021866981,
-0.009985347,
-0.005357344,
0.010767731,
0.034212742,
0.045006994,
-0.016443333,
-0.004435722,
0.0067364625,
-0.027144762,
0.015886381,
-0.014944868,
0.035140995,
0.022410672,
0.0052612037,
-0.00405779,
0.006640322,
-0.022423932,
0.037766624,
-0.008831661,
-0.00405779,
0.009222854,
0.026654113,
0.008201776,
-0.03190537,
0.003417959,
0.035326645,
0.009030573,
-0.028457576,
0.0036201854,
0.0020736502,
0.023232838,
0.025341298,
0.03752793,
-0.0053473986,
-0.0010484282,
0.008022755,
-0.010661645,
0.054289524,
0.011815331,
-0.0024747879,
0.021336552,
-0.003994802,
-0.02327262,
-0.12666671,
0.005794949,
0.004107518,
0.037448365,
-0.004376048,
0.03063234,
0.0025013094,
0.029544957,
-0.024386525,
0.022145458,
-0.017371586,
-0.025672818,
0.0062458147,
0.0047075674,
0.0062027173,
-0.017477673,
0.0007347286,
0.02604412,
-0.031799287,
0.04243441,
0.0109334905,
-0.0045186016,
-0.0062855966,
-0.023325665,
0.010462734,
0.012664019,
-0.032701015,
0.020859163,
0.024081526,
0.011430769,
-0.0041274093,
-0.018140709,
0.029836694,
0.011914786,
-0.028033232,
-0.013830965,
-0.00076953805,
-0.0067132562,
0.023140013,
-0.01620464,
-0.002511255,
-0.009236114,
-0.009236114,
-0.0064745625,
0.003414644,
-0.029465392,
-0.005493267,
0.0077774315,
-0.0032472268,
-0.017703105,
-0.04651872,
-0.006829288,
-0.024161091,
-0.0052578887,
0.014056398,
-0.0020885686,
0.015713992,
0.0059109805,
-0.0053241923,
-0.011165554,
-0.017915277,
-0.007200589,
-0.0186844,
0.0009398559,
0.031242333,
-0.0097996965,
-0.00562919,
-0.021920023,
0.023909137,
0.009428395,
0.00023807195,
0.00026666545,
-0.01639029,
-0.0008333554,
-0.016270943,
-0.0027184542,
-0.019281134,
-0.034955345,
0.0094880685,
0.004452298,
-0.0039086067,
-0.018034624,
0.0051650633,
-0.021349812,
0.015448777,
0.002494679,
0.0020388407,
0.00189463,
0.027065197,
0.012988907,
-0.0072337408,
0.04208963,
-0.020700036,
0.01074121,
-0.0060137515,
0.018817008,
-0.028271925,
0.019254614,
0.052459538,
0.026640853,
-0.033841442,
-0.021999588,
-0.05935513,
0.0048965327,
0.025619775,
-0.002985327,
0.01302206,
-0.023750009,
0.005794949,
0.009236114,
0.0047440343,
-0.005655711,
-0.0032356237,
-0.017716365,
-0.032303195,
-0.020328734,
-0.023789791,
-0.0037196411,
0.032807104,
-0.0134265125,
0.02941235,
0.029147135,
0.017928537,
0.0048899027,
-0.021906763,
0.0113512045,
0.010164367,
-0.0045384928,
-0.008427208,
0.016443333,
-0.007379609,
-0.028722791,
0.006461302,
-0.031268854,
-0.0134265125,
-0.011218597,
-0.014427699,
-0.0051153353,
-0.0015133835,
0.045882206,
0.022927841,
0.023909137,
-0.016125076,
-0.027714973,
0.014056398,
0.023988701,
-0.007823844,
0.020448081,
-0.018180491,
0.012047394,
-0.0086592715,
-0.019864608,
0.020315474,
0.010542299,
-0.012093807,
-0.015050954,
0.003308558,
0.007253632,
-0.0037229564,
-0.022410672,
-0.008354275,
-0.02310023,
0.026693895,
0.026866285,
-0.018419186,
0.007843736,
-0.007658085,
-0.011835222,
-0.010880448,
0.0031063315,
0.010250562,
-0.024426308,
-0.008128841,
0.026017597,
0.008387426,
-0.009395244,
0.010721318,
0.0088648135,
-0.013844226,
0.009965456,
-0.00023786475,
0.012186632,
0.0040146927,
-0.013433143,
-0.018432446,
0.018286578,
-0.0012655731,
0.010456104,
0.020341994,
0.01585986,
-0.004667785,
-0.015302909,
0.009322309,
0.008181885,
0.0045517534,
0.017411368,
-0.015780296,
0.02710498,
-0.009428395,
0.02129677,
0.0024764456,
0.020355256,
0.021813938,
-0.0066104853,
0.011994351,
-0.009826218,
-0.016323987,
0.026906068,
-0.018697662,
-0.04208963,
-0.0058281007,
0.008897965,
0.010814144,
0.0072138496,
0.008897965,
0.003573773,
-0.0044290912,
0.020129822,
-0.0007484037,
-0.020739818,
-0.014162484,
0.028139317,
0.020646991,
0.025115866,
0.016005728,
-0.010714688,
0.013353578,
0.02694585,
0.021177422,
-0.007306675,
0.012829779,
0.004611427,
0.012465107,
0.014189006,
-0.019983955,
-0.016284205,
-0.00019114131,
-0.012584454,
0.0022476977,
0.013320426,
-0.0009522878,
0.08131494,
0.027927145,
-0.01670855,
0.023750009,
-0.014480742,
0.037448365,
0.023922399,
0.031083204,
-0.023564357,
-0.032329716,
0.014918347,
-0.015130519,
0.021283507,
-0.033735353,
-0.008778619,
0.008188515,
0.018021364,
0.028484097,
-0.017079849,
0.0038787702,
0.0080360165,
-0.03081799,
0.009262636,
0.002491364,
-0.032117542,
0.0056789173,
0.035114475,
-0.0013534256,
0.0014445933,
-0.031693198,
0.0107345795,
0.004879957,
-0.016456595,
0.003679859,
-0.004565014,
-0.007240371,
-0.027370194,
-0.014003355,
0.031215813,
0.007366348,
-0.013346948,
0.00009577786,
-0.016443333,
-0.0099057825,
-0.0012042421,
-0.00378926,
-0.007339827,
0.0019178364,
-0.010151106
] |
Adult neurogenesis persists in the subventricular zone and the dentate gyrus and can be induced upon central nervous system injury. However, the final contribution of newborn neurons to neuronal networks is limited. Here we show that in neural stem cells, stimulation of the "death receptor" CD95 does not trigger apoptosis but unexpectedly leads to increased stem cell survival and neuronal specification. These effects are mediated via activation of the Src/PI3K/AKT/mTOR signaling pathway, ultimately leading to a global increase in protein translation. Induction of neurogenesis by CD95 was further confirmed in the ischemic CA1 region, in the naive dentate | [
-0.011862033,
-0.0060711983,
-0.01404486,
-0.030920055,
-0.017048752,
0.006842197,
-0.021387706,
0.0062213927,
-0.029024266,
-0.018223608,
0.02169477,
0.010720554,
-0.0034477997,
0.009018349,
-0.013991458,
-0.0010463555,
0.027302034,
0.012756525,
0.013183746,
0.014018159,
-0.013317252,
0.027395489,
0.00058659323,
-0.028970862,
0.009018349,
0.037328355,
-0.00377489,
-0.027221931,
-0.005730757,
-0.008704609,
0.009512322,
0.014311873,
-0.0098994905,
-0.021841627,
-0.0063949507,
0.0051700305,
0.0006091224,
-0.018610775,
-0.0025733334,
0.02424474,
0.0019291658,
-0.00005793964,
-0.012456136,
-0.0014318548,
-0.003784903,
0.005263485,
-0.010920813,
-0.011027618,
-0.0027602424,
0.03425771,
0.021641368,
0.0061079124,
-0.020987187,
0.0036447213,
-0.010206555,
-0.027128477,
-0.011247904,
0.009625803,
0.017622828,
-0.028330032,
0.0068355217,
-0.003386053,
-0.01340403,
0.021160746,
-0.007169287,
0.011721851,
0.010206555,
0.0223089,
0.0024398272,
-0.000045188746,
0.03417761,
0.024164636,
-0.014552184,
-0.011328008,
0.012289253,
-0.0003865424,
-0.018637476,
-0.010079724,
-0.0023947689,
0.004158721,
0.011568319,
-0.04405707,
-0.024191339,
0.03887703,
0.012529564,
-0.00046602037,
-0.026527697,
0.012396058,
0.009518998,
0.0070291054,
0.0092319595,
0.02061337,
0.012883356,
0.022162043,
0.0018123478,
0.008270714,
0.007062482,
0.010012971,
-0.0036647473,
-0.0083241165,
-0.014512133,
0.0024581843,
0.008924895,
-0.030946756,
-0.009398842,
-0.00075222447,
0.013377329,
-0.0101665035,
0.02529944,
-0.0003752778,
-0.020693474,
0.020680122,
-0.010333386,
-0.045739252,
0.025125882,
0.0012357675,
0.028570345,
0.025379544,
-0.011181151,
-0.009025024,
0.02616723,
0.011948812,
0.023737416,
-0.021013888,
0.0026067102,
0.040933024,
0.008444272,
0.0042087855,
-0.02360391,
0.012689772,
-0.003150748,
-0.0017188933,
-0.0014452055,
0.009565725,
-0.019692177,
0.014004809,
-0.0006020299,
0.0016880201,
-0.02189503,
-0.04533873,
0.006188016,
0.033857193,
-0.023430351,
0.0034578126,
0.005129979,
0.022215445,
0.027248632,
4.938037e-7,
0.01571369,
0.0013258843,
-0.007977,
-0.02317669,
0.011781929,
-0.02359056,
0.004622655,
0.023737416,
0.0018056724,
0.030145718,
-0.007569806,
-0.011701825,
0.0076499097,
-0.020319656,
-0.000063102576,
-0.0097926855,
0.0071359104,
0.016034104,
0.0027218594,
0.0033910596,
0.021628017,
-0.030279225,
0.005086589,
0.0361268,
-0.026968269,
0.028410137,
-0.03545927,
0.010032997,
0.004973109,
0.016327819,
-0.028436838,
0.004552564,
-0.014699042,
0.0027552359,
-0.0037114746,
0.024565155,
-0.0052034073,
-0.007422949,
0.024204688,
-0.020733526,
-0.0036113448,
-0.017983295,
-0.019171502,
0.008357493,
-0.011621722,
-0.026460944,
-0.63869405,
-0.038423106,
0.021214148,
0.011728527,
0.01893119,
0.05612604,
0.0010546996,
-0.0043155905,
-0.0318813,
0.0030689756,
-0.021147395,
0.016741687,
0.003764877,
-0.0007730848,
-0.029478187,
-0.012169098,
-0.016674934,
-0.0033126245,
0.027395489,
0.0024665284,
0.010259958,
-0.0030139042,
-0.019037995,
0.02337695,
-0.0027852748,
0.035405867,
0.028383436,
-0.01361764,
-0.004158721,
0.023937676,
-0.006842197,
0.0062514315,
-0.0027185215,
-0.008050429,
0.04937062,
-0.0043122526,
-0.0052167578,
0.022162043,
-0.0070691574,
0.03553937,
-0.026647853,
-0.0013116992,
0.019037995,
-0.0049163685,
-0.040265493,
0.008377519,
-0.0010146478,
0.011588345,
-0.008130533,
-0.0030739822,
0.023470404,
0.023750767,
-0.026193932,
0.00924531,
0.0093921665,
0.014552184,
0.015126262,
-0.013003511,
0.017729634,
0.024418298,
-0.0012124039,
0.0051099528,
-0.010760606,
-0.014992755,
-0.008764687,
0.026193932,
-0.021654718,
-0.009852763,
0.0111277485,
-0.019291658,
0.0119287865,
0.0057174065,
-0.0007217683,
-0.013217121,
0.01136806,
0.024778765,
0.012082318,
0.0054437188,
-0.012582967,
0.0159273,
-0.011181151,
-0.019825682,
-0.02509918,
0.015433326,
0.0072894427,
-0.008758012,
-0.008984973,
0.013484134,
-0.0056740167,
0.009105128,
-0.0031290534,
0.0063582365,
-0.013210447,
-0.052574772,
-0.010460217,
0.017756335,
0.010053023,
0.018103452,
0.011815306,
-0.037141446,
-0.0055405106,
0.0223089,
0.011448164,
0.004662707,
0.010733905,
0.008057104,
-0.038556613,
0.009786011,
0.05660666,
-0.02210864,
-0.013230472,
0.019852383,
0.0069623524,
-0.009185232,
-0.009238634,
-0.01445873,
0.014365275,
0.009518998,
0.009892816,
-0.039384354,
0.0066519505,
-0.012870005,
0.0050064856,
-0.009111804,
0.031213768,
-0.00092619983,
0.010206555,
0.0028353396,
-0.012416084,
-0.010159828,
-0.011828656,
-0.005694043,
0.011454838,
-0.015353222,
0.020479864,
0.004679395,
0.010093074,
0.0036313708,
0.0050331866,
-0.026581101,
-0.03551267,
0.014765794,
0.012723149,
-0.016087506,
-0.014552184,
0.017048752,
-0.010293334,
0.0077300137,
-0.0088581415,
-0.0021144056,
0.002413126,
-0.006989054,
0.002431483,
0.0090317,
0.024925623,
-0.000026935935,
-0.019451864,
-0.013911354,
-0.0036747605,
-0.020493213,
0.00420211,
0.030679744,
-0.018864438,
0.013043564,
-0.034631528,
0.0006683658,
0.006725379,
0.012803252,
0.01571369,
-0.03043943,
-0.014926002,
-0.0075431047,
-0.01189541,
0.0062414184,
0.008891518,
-0.0008302422,
-0.019879086,
-0.005994432,
-0.007803442,
0.013270524,
0.0023981065,
-0.029905407,
-0.0051333164,
-0.0026784698,
0.02937138,
0.020880383,
0.02955829,
0.022469107,
0.010533646,
0.021561265,
-0.0059310165,
0.03740846,
-0.031373974,
0.008464298,
-0.008677908,
-0.047101017,
-0.0010355081,
0.0028720538,
0.00029955473,
0.027742606,
0.0055505238,
-0.02467196,
0.017195608,
0.0056039263,
0.020853681,
-0.010159828,
-0.010707203,
-0.032495428,
0.00030268377,
0.012462812,
0.006915625,
0.003911734,
0.012736499,
-0.0170354,
0.010133127,
-0.00361802,
0.006041159,
-0.01223585,
0.0026067102,
-0.023256794,
0.0056306273,
-0.0045659146,
-0.0012099007,
-0.011755228,
0.0015336534,
0.04638008,
0.0009095115,
0.014084913,
-0.002129425,
-0.028837357,
-0.0020776915,
0.025820114,
0.0077967667,
0.015767092,
0.0006199698,
0.012542915,
-0.0071959887,
-0.007162612,
0.005867601,
0.016447974,
0.0050064856,
0.024738714,
-0.012162422,
0.01115445,
-0.0047027585,
0.008998323,
0.020065993,
0.00893157,
-0.021200797,
0.012382708,
-0.016541429,
0.0026617814,
-0.014285172,
-0.0028870732,
0.011995539,
-0.006768768,
0.0112345535,
0.0074763517,
0.026300738,
0.02998551,
0.018477269,
-0.009505647,
0.007669936,
-0.017355816,
-0.0001518634,
0.016955297,
0.012683096,
0.0016663253,
0.0055839,
-0.02467196,
-0.01424512,
0.0018123478,
-0.00830409,
-0.015606884,
0.0046860706,
-0.0048963428,
0.01746262,
0.0107806325,
0.0035212282,
0.0041220062,
0.017662881,
-0.0233636,
0.037541967,
0.02507248,
-0.011848683,
-0.0063615744,
-0.00061120844,
-0.011534942,
-0.0066018854,
0.018370464,
-0.01319042,
0.024351545,
-0.01424512,
0.0016246046,
-0.015246417,
-0.01425847,
0.0039551235,
-0.021347655,
0.0060077826,
-0.01616761,
0.009692556,
-0.0033810465,
-0.015553482,
-0.018156854,
0.020640071,
-0.0098460885,
0.009832737,
-0.01404486,
-0.0033593518,
-0.013230472,
-0.005623952,
-0.0045358757,
-0.0027385475,
-0.02105394,
0.005887627,
-0.006578522,
0.01210902,
0.012502863,
0.011828656,
0.027288683,
-0.012409409,
-0.011655098,
-0.012829954,
-0.031213768,
0.041814167,
0.028650448,
-0.009966244,
0.015086209,
0.008203961,
-0.0026984958,
-0.009078427,
0.003551267,
0.016327819,
-0.029451486,
-0.007656585,
-0.003668085,
-0.0005623952,
-0.0106738275,
0.0318813,
0.027956216,
0.0026884826,
-0.007836819,
-0.018036699,
-0.025472999,
0.010199879,
-0.0011715177,
0.017556075,
0.026727958,
0.021948433,
-0.0023714053,
0.018343763,
0.026127178,
0.00659521,
-0.011721851,
-0.0052501345,
0.015419975,
-0.0003692283,
0.015339872,
-0.017823089,
-0.028997565,
0.0056106015,
0.017195608,
0.028036319,
0.003688111,
0.019972539,
-0.005700718,
0.017102154,
-0.012836629,
0.0068622227,
-0.02208194,
0.013056914,
0.009779335,
-0.019745579,
-0.027929513,
0.027115125,
-0.024992375,
-0.03318966,
-0.015233067,
0.008911544,
-0.0023079899,
0.00060495036,
0.0018440555,
0.0024198014,
0.0037982536,
-0.02381752,
-0.024805468,
0.0111678,
-0.014912652,
-0.0028486901,
-0.014845898,
-0.0002282123,
0.01659483,
-0.024284793,
-0.011281281,
0.011955488,
-0.012769876,
-0.03361688,
0.0076031825,
-0.0017389193,
0.018303711,
0.025005726,
-0.006551821,
-0.010560347,
0.02998551,
-0.000067170346,
-0.02744889,
-0.019652124,
-0.016261065,
0.026247334,
-0.00034795073,
0.0023096586,
-0.03043943,
-0.005694043,
0.00046685478,
0.018263659,
-0.019251605,
0.013477459,
-0.0046293302,
-0.01125458,
0.0028687161,
0.03441792,
0.025820114,
0.016888544,
-0.0004789538,
0.013484134,
-0.027315386,
-0.011761903,
-0.015913948,
-0.019198203,
-0.030653043,
-0.003494527,
0.013377329,
-0.006231406,
-0.004449097,
0.02424474,
-0.007309469,
0.024311494,
0.007202664,
0.013323926,
0.0115282675,
0.029451486,
0.016634883,
0.00072886085,
-0.0013317252,
0.018851086,
-0.010820684,
0.026768008,
0.019398462,
0.002121081,
-0.0040218765,
0.007442975,
0.0008552746,
-0.01594065,
0.013991458,
0.007903572,
0.020733526,
0.0089382455,
-0.029718498,
-0.0067587555,
-0.020973837,
0.019385112,
0.0033977348,
-0.0038316303,
-0.02104059,
-0.0057641338,
-0.0019642112,
-0.008037078,
-0.008050429,
0.028650448,
-0.038796924,
-0.003434449,
0.008344143,
0.026768008,
-0.0025933594,
-0.04021209,
0.010139802,
-0.01094084,
0.0014802509,
-0.016768388,
-0.031240469,
0.021494512,
-0.0073027937,
0.023750767,
0.013924705,
0.053696226,
0.02913107,
0.010039672,
0.017929893,
0.018664178,
0.0030890016,
-0.0006775444,
0.042989023,
-0.017662881,
0.046486888,
-0.03444462,
-0.0046460186,
0.024765415,
-0.016848493,
0.015032807,
0.028196527,
0.0015453352,
-0.03850321,
0.004769512,
-0.031240469,
-0.032682337,
0.021280902,
-0.02784941,
-0.007943624,
-0.02337695,
0.01179528,
0.039491158,
0.011034294,
-0.007896896,
-0.0011456507,
0.011668449,
-0.024979025,
0.022375653,
0.011494891,
0.013130343,
-0.0010296672,
-0.0060478346,
0.016688285,
0.010573697,
0.01253624,
-0.0010063036,
0.0011181151,
0.020519916,
-0.0017072116,
-0.006228068,
0.003571293,
-0.017275713,
-0.019678826,
-0.022202095,
-0.038957134,
-0.016020754,
-0.019411813,
-0.01893119,
-0.020346357,
-0.013924705,
0.016301116,
-0.015873896,
0.028009618,
-0.017702933,
-0.012609668,
0.013991458,
-0.020279603,
0.029237876,
-0.017489323,
0.014058211,
0.017409218,
0.0071158847,
-0.020373058,
-0.006742067,
-0.00010878676,
0.00042659428,
0.035165556,
0.029237876,
-0.02082698,
-0.017115505,
0.0087780375,
0.020893732,
-0.013530862,
-0.0065317946,
0.015593533,
-0.0013008518,
0.0060077826,
-0.006124601,
-0.025219336,
-0.028009618,
0.009405517,
-0.0031974753,
-0.022228796,
0.018450567,
-0.008484324,
-0.007910247,
0.031160366,
-0.006585197,
0.018624127,
0.0013984783,
-0.0103267105,
-0.013003511,
-0.007983675,
-0.0017272375,
0.018517321,
-0.015326521,
0.04739473,
-0.0028720538,
-0.0048195766,
0.019678826,
0.017809737,
-0.0013058583,
0.0064984183,
0.002091042,
0.040185392,
0.008277389,
-0.011441488,
0.02937138,
-0.010046348,
-0.007977,
-0.013283875,
-0.008170584,
-0.011615046,
-0.046914108,
-0.017742984,
0.0092586605,
0.010019646,
0.016314467,
-0.0038249549,
-0.027008321,
-0.022482457,
-0.028623747,
-0.020373058,
0.023457054,
-0.032442026,
0.0037615395,
-0.0042288112,
0.02423139,
0.019318359,
-0.0070891837,
0.003551267,
0.008203961,
0.025659908,
-0.02379082,
0.022869626,
0.019505268,
0.011374735,
-0.020306306,
0.008998323,
-0.0010697191,
-0.0088581415,
0.013938055,
-0.013497485,
-0.028249929,
-0.0034678257,
-0.012382708,
0.029264577,
0.023216741,
-0.0071492614,
0.030172419,
-0.003384384,
-0.0015461696,
0.0060578473,
-0.026073776,
0.017542725,
-0.020159448,
-0.010039672,
-0.00945892,
-0.03083995,
-0.026087128,
-0.017569426,
0.005340251,
0.013096966,
-0.013951406,
-0.013570913,
-0.010787307,
-0.0047895378,
-0.012282577,
-0.012836629,
0.0016663253,
-0.0100863995,
-0.035993293,
0.013203771,
0.01138141,
-0.01618096,
0.00084651326,
0.03337657,
-0.0089649465,
0.000017327133,
-0.0038316303,
0.0050031478,
-0.00045350415,
-0.04376336,
-0.044297382,
0.012656395,
-0.025673257,
0.027769307,
0.023016483,
-0.0031691054,
-0.013804549,
-0.017809737,
-0.05332241,
0.00723604,
0.004525863,
0.014979404,
0.00015374082,
0.019545319,
-0.028330032,
-0.025886867,
0.0061846785,
0.016261065,
0.013504161,
-0.002938807,
0.021334304,
0.00051191315,
0.015259768,
-0.0004802054,
-0.012376032,
-0.020079345,
0.020760227,
-0.012342655,
-0.015193014,
0.011408112,
-0.015019457,
0.00072218553,
0.00404524,
-0.0016187637,
0.009625803,
0.025192635,
0.0100062955,
-0.036206905,
-0.00003405453,
0.013210447,
-0.0005081583,
-0.0080304025,
-0.018477269,
-0.0059877564,
0.008010377,
0.0058709388,
-0.022629315,
-0.0106271,
0.013143693,
0.0017155557,
0.013056914,
0.010386788,
0.0042955647,
0.020813629,
0.014632288,
-0.005517147,
-0.016274415,
0.006518444,
-0.0044891485,
-0.009866114,
-0.011601696,
-0.012569617,
0.011748552,
-0.0054904455,
0.020493213,
-0.031320572,
0.02571331,
-0.005810861,
0.011214527,
-0.03252213,
0.017088804,
0.007169287,
-0.015460027,
-0.00626812,
0.008584454,
-0.019425163,
-0.03254883,
-0.010179854,
-0.0038383056,
-0.016514726,
-0.025873518,
0.0015979033,
0.0023714053,
-0.01596735,
-0.014912652,
-0.0108874375,
-0.0024214701,
0.008230662,
0.1827434,
-0.014271821,
-0.002793619,
-0.014605587,
-0.0047795246,
-0.0085177,
0.02998551,
-0.0070891837,
0.010907463,
-0.022495808,
0.0022445743,
0.018997943,
-0.003299274,
-0.0072894427,
0.021454459,
-0.024565155,
-0.0010588716,
-0.008871492,
-0.008758012,
-0.024097884,
0.005914328,
-0.018410515,
-0.0046460186,
0.0071158847,
0.033536777,
0.01169515,
-0.039037235,
0.013170394,
0.025753362,
0.0031891312,
-0.03593989,
0.005420355,
-0.0048996806,
0.007669936,
0.0046860706,
-0.014365275,
-0.022482457,
-0.01136806,
0.019598722,
-0.0088581415,
0.0212542,
0.00032291832,
-0.018624127,
0.013911354,
-0.017689582,
0.038903728,
0.010573697,
-0.007977,
-0.0072894427,
-0.0031407352,
-0.045312032,
-0.013143693,
0.0071492614,
0.0047795246,
0.0053969915,
-0.0034678257,
-0.003638046,
0.016488025,
0.004759499,
0.01934506,
-0.020359708,
0.006775444,
-0.038476508,
0.035405867,
-0.005827549,
0.0094722705,
-0.008571103,
0.011261255,
0.026834762,
-0.017729634,
0.008097156,
-0.008871492,
-0.035432566,
0.0028637096,
-0.02340365,
-0.014151665,
0.015820494,
-0.014618938,
0.011962162,
0.01639457,
0.023563858,
-0.00086445315,
-0.017102154,
0.0010864073,
-0.0043189283,
-0.035245657,
0.019238254,
0.0063515613,
-0.01746262,
0.0018740944,
0.012689772,
-0.0038483185,
-0.011194502,
-0.011301307,
0.014298523,
-0.0086712325,
0.012195799,
0.0069423267,
0.0071559367,
-0.0011389755,
-0.037995886,
0.087686926,
0.013544212,
0.0019141462,
0.00515668,
0.009539024,
0.004479136,
0.035592776,
-0.01829036,
0.00065918727,
0.0019158152,
-0.003083995,
0.0009562387,
-0.0012624688,
-0.014632288,
0.021614667,
-0.020092696,
-0.028837357,
0.04549894,
-0.021214148,
-0.01447208,
-0.021654718,
-0.0032492091,
0.033429973,
0.004055253,
-0.0016362864,
-0.024324844,
-0.01827701,
-0.018811034,
-0.042802114,
-0.0077700657,
-0.011221203,
-0.00616799,
0.008277389,
0.01722231,
0.005760796,
0.019972539,
-0.012916733,
-0.004876317,
0.026287386,
-0.017836438,
-0.005704056,
-0.0029338005,
-0.009972919,
-0.0021043927,
-0.012482837,
0.017115505,
0.026087128,
-0.008490999,
-0.00945892,
-0.016541429,
-0.025059128,
-0.003094008,
0.005176706,
0.00754978,
-0.027395489,
-0.020586668,
-0.041467052,
-0.018170204,
-0.0020977175,
-0.03062634,
0.0033526765,
-0.006685327,
-0.012629694,
-0.012342655,
-0.010186529,
-0.1681111,
-0.0051333164,
0.020025942,
-0.029691797,
0.040933024,
0.008197285,
-0.0053102123,
-0.0047060964,
0.0026551061,
0.02041311,
0.03145408,
-0.004619317,
-0.031534184,
-0.01212237,
0.012469486,
0.005944367,
0.03062634,
0.04483141,
0.008330792,
0.023470404,
0.020519916,
-0.013610966,
0.02084033,
0.0005369456,
0.009165206,
-0.0058242115,
-0.005039862,
-0.022375653,
0.000987112,
-0.014432029,
-0.011448164,
-0.009652504,
0.0059577175,
0.001591228,
0.011281281,
0.011147775,
0.008197285,
-0.009732608,
-0.01614091,
0.020880383,
0.0092853615,
0.026340788,
-0.0024248078,
0.0020810291,
-0.006238081,
0.023283495,
0.0014652314,
-0.011187826,
0.014098263,
-0.0087246355,
0.008397545,
-0.0075764814,
-0.009325414,
0.02445835,
0.0046259924,
0.009992945,
0.010793983,
0.012930083,
0.012829954,
-0.00027744274,
0.0072160144,
-0.013884653,
0.030038914,
0.009418868,
-0.002413126,
-0.04296232,
-0.004759499,
0.0010371769,
-0.031587586,
0.007936948,
-0.031747792,
-0.010226581,
0.025045779,
-0.031320572,
0.009759309,
0.01424512,
-0.015847195,
-0.004866304,
-0.0039584613,
0.018877788,
0.009352115,
0.023657313,
-0.016221013,
-0.026581101,
-0.02253586,
0.004913031,
0.02787611,
0.019251605,
0.01871758,
-0.012369357,
-0.009745958,
-0.031801194,
0.014939353,
-0.0004747817,
0.022068588,
0.020706823,
-0.008003701,
-0.008317442,
0.008470973,
0.016554778,
0.022829574,
0.008624505,
-0.023083236,
0.0074296244,
0.03545927,
-0.007442975,
-0.03764877,
0.012643045,
0.028864058,
-0.0038750197,
0.0030005537,
0.013884653,
-0.0045191874,
0.010179854,
-0.0021527887,
0.020439811,
0.0043890188,
0.004562577,
-0.0021678081,
-0.026901515,
0.063976206,
0.015686987,
-0.0008969953,
0.013590939,
0.008811414,
-0.04269531,
-0.13404031,
-0.03850321,
-0.0070291054,
0.026087128,
-0.024378248,
0.010106426,
0.0041620582,
0.023336899,
-0.01829036,
0.017702933,
-0.030519536,
-0.019264957,
0.008310766,
-0.0051700305,
0.013884653,
-0.0072226897,
0.018317062,
0.002169477,
-0.022789521,
0.027248632,
-0.0116350725,
-0.0024548466,
-0.010687178,
-0.010687178,
-0.00605451,
0.025566453,
-0.023991078,
0.009972919,
0.010907463,
0.005049875,
0.011601696,
-0.014618938,
0.02337695,
-0.0026450932,
-0.031827897,
-0.012623019,
0.012249202,
-0.03759537,
0.031640988,
-0.021320952,
0.0055037965,
0.025579803,
0.037808977,
0.0049096933,
-0.012275903,
0.009278687,
-0.009525673,
0.007823468,
0.0008886512,
-0.024765415,
-0.030252524,
-0.010920813,
-0.0098727895,
0.018130153,
0.02314999,
-0.010747256,
0.027528996,
-0.0068555474,
-0.00297719,
-0.0039584613,
0.012215825,
0.014992755,
-0.025806764,
0.0069289757,
0.033002753,
-0.0032492091,
-0.05703388,
-0.047741845,
0.0057574585,
-0.0074963775,
0.015980702,
-0.01274985,
-0.00819061,
-0.0028053008,
-0.031801194,
-0.0024999052,
-0.0022162043,
-0.014298523,
0.0019491917,
-0.011675124,
-0.018784333,
-0.01572704,
0.020973837,
-0.0098994905,
0.020666772,
-0.0011431475,
0.011701825,
0.0022328924,
0.009211933,
-0.00313406,
-0.0071826377,
0.03356348,
-0.0066085607,
-0.011955488,
-0.007970325,
0.0069690277,
0.0080304025,
-0.009418868,
0.020907084,
0.018050049,
-0.009345439,
-0.014565535,
-0.04338954,
0.009318738,
-0.01041349,
-0.018090101,
0.0044824732,
-0.016768388,
0.0056306273,
-0.021334304,
-0.008210636,
-0.0106204245,
-0.012042266,
-0.0022429056,
-0.006848872,
0.017809737,
-0.0276358,
-0.03468493,
0.043042425,
-0.00056197797,
0.0071959887,
0.039891675,
0.013711095,
-0.019959189,
0.003474501,
-0.01243611,
-0.0067887944,
-0.008871492,
-0.011848683,
0.0046460186,
0.013504161,
-0.0057841595,
0.016741687,
-0.056393053,
-0.0019541981,
-0.0077500395,
-0.011715176,
-0.015059508,
-0.0010505276,
0.027128477,
0.0065618334,
0.033963997,
-0.041814167,
-0.033696987,
-0.0050632255,
-0.013530862,
0.00754978,
-0.010153153,
-0.025139233,
0.010053023,
-0.013951406,
-0.021080641,
0.022789521,
-0.0012149072,
-0.008544402,
-0.017836438,
-0.033483375,
0.009512322,
-0.008911544,
0.01639457,
-0.020586668,
-0.018317062,
0.0042955647,
0.006208042,
0.007810117,
0.009999621,
0.015393274,
-0.0223089,
-0.020319656,
0.0070691574,
-0.014485431,
-0.008003701,
-0.02188168,
0.0012115695,
0.02208194,
0.008417571,
-0.0049297195,
-0.021441108,
0.00016114625,
-0.009532348,
-0.036687527,
0.0039083962,
0.007823468,
0.011214527,
-0.018784333,
0.011628397,
0.018997943,
0.00786352,
-0.017903192,
0.032442026,
0.016488025,
-0.0004626827,
0.0011448164,
0.01870423,
0.026794711,
0.012656395,
0.0075164037,
0.034551427,
-0.026407542,
0.004545889,
-0.012402734,
0.01743592,
0.0052835112,
0.01639457,
0.005981081,
-0.018610775,
0.0031807872,
0.035218958,
-0.028757252,
-0.02509918,
-0.020880383,
-0.0086445315,
0.014819197,
0.019224904,
-0.0025266064,
0.010860736,
-0.008257363,
0.008050429,
0.0111277485,
-0.0055672117,
0.0012015565,
0.014779145,
0.023430351,
0.00083441427,
0.0076165334,
-0.009465595,
0.021147395,
0.0054971213,
0.04125344,
-0.008924895,
0.03375039,
-0.028143125,
0.031534184,
-0.0040252144,
-0.039250847,
0.0014143322,
-0.012716473,
-0.030466134,
0.010320036,
0.011862033,
-0.002286295,
0.079996966,
0.015994051,
-0.012349331,
-0.020039292,
-0.01232263,
0.0022896328,
-0.01094084,
0.01636787,
-0.02487222,
-0.05252137,
0.034391217,
-0.02680806,
0.045846056,
-0.026460944,
-0.0055104718,
0.012095669,
-0.020720175,
0.04015869,
0.013964756,
-0.0052801734,
0.015032807,
-0.0102733085,
0.0053168875,
0.015353222,
-0.02529944,
0.013871303,
0.028650448,
-0.022602614,
0.007463001,
-0.020172799,
0.0068955994,
0.010680502,
-0.03273574,
0.007676611,
-0.026340788,
-0.0026400867,
-0.020426461,
-0.024952324,
-0.005013161,
0.02316334,
-0.007890221,
0.008023728,
-0.011888734,
-0.042241387,
-0.0015294813,
-0.01403151,
-0.018904489,
-0.026647853,
-0.0008544402
] |
Allogeneic umbilical cord blood (UCB) has therapeutic potential for cerebral palsy (CP). Concomitant administration of recombinant human erythropoietin (rhEPO) may boost the efficacy of UCB, as it has neurotrophic effects. The objectives of this study were to assess the safety and efficacy of allogeneic UCB potentiated with rhEPO in children with CP. Children with CP were randomly assigned to one of three parallel groups: the pUCB group, which received allogeneic UCB potentiated with rhEPO; the EPO group, which | [
-0.006470749,
-0.022359518,
0.020677255,
-0.027684474,
-0.0067621646,
0.018597608,
0.00083947537,
0.0063250414,
-0.025339903,
-0.008676235,
-0.020425579,
0.0044109714,
-0.0067058685,
-0.0018362489,
-0.016981578,
-0.0044109714,
0.024969012,
0.0054011215,
-0.014795961,
0.026532058,
-0.012285813,
0.009206081,
-0.010464466,
-0.010464466,
-0.01507413,
-0.0024389492,
0.0334598,
-0.024478903,
0.026969181,
-0.020544793,
0.025472365,
-0.01314019,
0.013047467,
-0.01270969,
-0.0055236486,
-0.021644225,
0.0037056133,
-0.0097094355,
0.033168383,
0.021895902,
0.028373275,
0.012769298,
-0.009106735,
-0.01055719,
-0.00081091333,
-0.0056196833,
-0.0066330144,
-0.033963155,
-0.01686236,
-0.00075254746,
0.017855823,
-0.001576293,
-0.00696748,
0.014133653,
-0.0070270877,
0.004255329,
-0.009232573,
0.019604316,
0.00896765,
-0.011974528,
0.01507413,
0.015206591,
-0.010954574,
0.0026508877,
-0.0060071335,
0.005083214,
0.0010240937,
0.00679528,
0.01814724,
0.014199884,
0.020571286,
0.013524329,
0.00041559828,
-0.018372424,
0.02569755,
0.0064177644,
-0.023949057,
-0.017908808,
0.0033214747,
0.0065171104,
0.02307481,
-0.016054345,
-0.014146899,
0.022982087,
0.0042222133,
-0.019736778,
-0.016875608,
0.0038711901,
-0.014001191,
-0.0039639133,
0.010683028,
0.011020805,
0.01890227,
-0.011285728,
-0.006609834,
0.024425918,
0.0047785523,
0.04352688,
0.0022286663,
-0.015153606,
-0.0025233934,
0.0128553985,
-0.020346101,
-0.019630808,
-0.01386873,
-0.0025896241,
0.009285558,
-0.007305257,
0.024598118,
0.00793445,
-0.017789593,
0.046891406,
-0.006232318,
-0.022107841,
0.01782933,
0.0063283527,
-0.00022290803,
0.010126689,
-0.011325466,
0.014968161,
0.001972022,
0.02197538,
0.018054515,
-0.016014608,
0.012636837,
0.013643544,
-0.042811587,
-0.009947866,
0.0016276219,
-0.019034732,
-0.013285899,
0.0019273163,
0.016822623,
0.007517196,
-0.033989646,
0.035446722,
-0.024266966,
-0.020187147,
-0.047315285,
-0.02359141,
0.008086781,
0.016981578,
0.0013155092,
0.01462376,
-0.029512445,
0.0066694412,
0.026505565,
0.025432628,
0.014954914,
-0.019776516,
0.0012774265,
-0.00470901,
0.019511594,
0.00263433,
-0.014756222,
-0.0135375755,
0.013166683,
0.03833439,
-0.01027902,
-0.038625803,
-0.022597948,
-0.035102323,
-0.015153606,
-0.008921289,
-0.004586483,
0.01055719,
-0.012656705,
-0.0056329295,
0.03200272,
-0.014637006,
-0.014915176,
0.036373954,
-0.014027683,
-0.008080157,
-0.020094424,
-0.014464807,
-0.001705443,
0.018822793,
-0.026638027,
-0.020809717,
-0.0028263994,
-0.003576463,
0.024823304,
0.015405284,
0.01122612,
-0.020875948,
0.033380322,
-0.028452752,
-0.001611892,
-0.02221381,
-0.0070668263,
0.008080157,
-0.006954234,
-0.020081177,
-0.6358157,
-0.014425068,
-0.004540121,
-0.008517281,
0.024810057,
0.0088285655,
0.009795535,
-0.015988115,
0.0024869666,
0.027287088,
0.020584533,
0.024743827,
-0.013577314,
-0.0021574683,
-0.001885922,
-0.012689821,
-0.0011507601,
-0.017577654,
0.023564918,
-0.00028396456,
-0.02773746,
0.0024207358,
-0.009855143,
0.00200017,
0.017749853,
0.031711306,
0.01969704,
-0.004483825,
-0.020081177,
0.016637176,
0.019644056,
0.03253257,
0.008398065,
0.0086961035,
0.058177132,
-0.0025382955,
-0.013696529,
0.0063184183,
-0.022001872,
0.014954914,
-0.008033796,
-0.0046692714,
0.019220177,
0.0038115825,
-0.014676745,
0.04373882,
0.016239792,
-0.019326147,
-0.009106735,
0.005285218,
0.014491299,
0.024823304,
-0.0036592516,
-0.01410716,
-0.0046262215,
-0.012444767,
0.00845105,
-0.01098769,
0.0140541755,
-0.016928593,
-0.0065171104,
0.0031873572,
-0.015882146,
-0.028505735,
0.021856165,
0.014292606,
-0.027578505,
-0.006960857,
0.00395729,
-0.011729474,
0.017551161,
0.015524499,
0.009000765,
0.008424558,
0.015312561,
-0.005003737,
0.010762505,
-0.018491639,
-0.026253888,
0.00888155,
-0.015749684,
0.00002799286,
-0.0060667414,
0.020597778,
0.015882146,
0.01514036,
-0.03642694,
0.026929444,
0.0074244724,
-0.012775921,
-0.011219498,
0.010696274,
-0.009523989,
-0.039023187,
-0.02279664,
0.007795365,
-0.011385075,
-0.0027634802,
0.014372083,
-0.0066032107,
-0.019365886,
-0.0009793879,
-0.0087623345,
0.011053921,
0.011451305,
0.0048778984,
-0.013550822,
-0.0008295408,
0.032585554,
-0.049169745,
-0.0181075,
-0.015696699,
0.013670037,
-0.0026078378,
0.047368266,
-0.03200272,
-0.012458013,
0.004434152,
-0.0052951523,
-0.04511642,
0.007735757,
-0.017670378,
-0.0067422953,
-0.0015348988,
-0.0049375063,
-0.010272397,
0.013948206,
-0.010656536,
-0.006888003,
-0.023366226,
0.008318588,
-0.011173136,
0.01969704,
-0.02421398,
0.05232233,
0.0064276992,
0.033989646,
-0.02369738,
-0.014372083,
-0.003470494,
-0.03245309,
0.0018991681,
-0.00069956284,
0.0075900494,
0.003728794,
-0.01365679,
-0.023657642,
-0.0049209483,
-0.026055196,
-0.0041990327,
-0.0008759023,
0.0015034392,
-0.015842408,
0.0107426355,
0.0020283181,
-0.019895732,
-0.011100282,
-0.022703918,
0.0029919764,
-0.025432628,
-0.006513799,
0.029883336,
0.002909188,
0.0052653486,
-0.018822793,
-0.0064773723,
-0.015709946,
0.0047619944,
-0.0013444852,
-0.013113698,
-0.005444172,
-0.018849285,
-0.003167488,
0.009192835,
-0.001950497,
0.00023780996,
-0.018703578,
-0.009225951,
-0.0030929784,
0.014742976,
-0.005391187,
0.0017551162,
-0.015815916,
-0.010239282,
0.023538426,
-0.004006963,
0.013789252,
0.019485101,
-0.0019952029,
0.0348374,
-0.030466167,
0.04763319,
-0.027287088,
0.03263854,
0.0044010365,
0.011133397,
-0.012405029,
0.029485952,
0.014809207,
0.025790272,
0.025326658,
-0.02283638,
0.031207953,
0.0020134163,
0.019988455,
-0.026505565,
-0.007298634,
-0.0189685,
0.025127966,
-0.010649912,
-0.015431776,
0.010490959,
-0.0002123525,
0.012126859,
-0.010782374,
0.008258981,
-0.016054345,
-0.0043149367,
-0.00041332157,
-0.00526866,
0.0040864404,
-0.0179353,
0.006305172,
0.017259747,
0.0018130682,
-0.0014148555,
0.013398491,
0.02645258,
-0.003447313,
-0.016372254,
0.0036625632,
0.030466167,
0.017537916,
-0.0012467948,
-0.005288529,
0.0123719135,
0.017087545,
-0.017524669,
0.020465316,
0.025512103,
0.0076562804,
0.0135375755,
0.0136038065,
-0.0061429064,
0.021776687,
-0.008159635,
0.016756393,
0.006391272,
-0.010689651,
0.033883676,
-0.014584022,
0.020293117,
-0.028161336,
-0.002339603,
-0.0061594644,
0.0032618667,
0.0052222987,
0.0026757242,
0.022823133,
0.018743316,
0.031207953,
0.00046775502,
0.0041228672,
-0.01055719,
-0.0019455297,
0.006017068,
0.009424643,
-0.013272652,
-0.038201924,
0.0017302796,
-0.021630978,
-0.012285813,
0.009259066,
-0.024187488,
0.0060137566,
0.0025647876,
-0.0010762505,
0.0034175091,
0.022412503,
0.0075635575,
0.01490193,
-0.031340413,
-0.0063680913,
0.042281743,
-0.021816425,
0.013093829,
-0.029591922,
0.0027452665,
-0.0123056825,
0.005262037,
-0.0010721111,
0.014266114,
0.0028098417,
0.023472195,
0.016584191,
-0.017220007,
0.011259235,
-0.0083119655,
0.027922904,
-0.023564918,
-0.0008825254,
0.0040765055,
-0.02021364,
-0.006341599,
0.021670718,
0.020531548,
-0.004023521,
-0.015537745,
0.015974868,
-0.019087717,
0.0029754187,
-0.016332515,
0.0014943324,
0.010524074,
0.010080327,
-0.0012650082,
-0.005831622,
0.019167194,
0.026015459,
0.00069956284,
-0.022134334,
-0.02969789,
-0.005278595,
0.0013660103,
0.0372482,
0.016544454,
0.011000936,
0.020452071,
0.0057885717,
-0.0030515841,
0.003937421,
-0.031817276,
0.021286579,
0.0014372084,
0.0021210413,
0.0012592131,
0.011895051,
-0.009927996,
-0.0028744168,
0.032850478,
-0.010510827,
-0.026585042,
0.005069968,
-0.007841727,
0.0070602032,
0.013166683,
0.029300505,
0.027578505,
0.017630639,
0.019299654,
0.021842917,
0.007033711,
-0.003016813,
-0.0196573,
-0.034890383,
0.014968161,
-0.0059077875,
0.018981747,
-0.0158689,
-0.025127966,
0.00544086,
-0.0067422953,
0.028267305,
0.021485271,
0.0338042,
0.024253719,
0.0017518046,
-0.009808782,
0.018928763,
-0.007848349,
0.014531038,
-0.0087623345,
-0.011252613,
-0.012060628,
0.04040079,
-0.017498177,
-0.005864737,
-0.0062290067,
0.016822623,
0.012537491,
-0.01782933,
0.00071363687,
0.009656451,
-0.0029820418,
0.008040419,
-0.0206905,
0.018889023,
0.0025830013,
-0.020319609,
0.0005012844,
-0.02062427,
-0.00905375,
-0.027922904,
-0.009974359,
-0.014888683,
0.021220349,
-0.023458948,
0.010616797,
0.023167534,
-0.0029538937,
0.035340756,
-0.0027684474,
-0.009961112,
0.013146814,
-0.023313241,
-0.030015798,
-0.0014049208,
-0.018610854,
0.015683454,
0.012828906,
0.01472973,
-0.008093404,
-0.022491978,
-0.0015092343,
0.0122394515,
-0.005500468,
0.019776516,
-0.0028230879,
0.015339053,
0.012040759,
0.030519152,
0.015100623,
-0.014676745,
-0.016769638,
-0.011265859,
-0.027008919,
-0.005281906,
-0.0076761497,
0.019445363,
0.007523819,
-0.022174072,
0.007033711,
0.0044142827,
-0.022809887,
0.024929272,
-0.019339394,
0.015445022,
-0.0014786026,
0.017604146,
0.003281736,
-0.013921714,
0.003283392,
0.03059863,
-0.018438654,
-0.02586975,
-0.023445703,
0.02186941,
0.00035081626,
-0.020928932,
0.0020846145,
0.013736268,
-0.020438824,
-0.0022535028,
0.0021740259,
-0.018862532,
0.04352688,
0.01935264,
0.0012981236,
-0.030333705,
-0.030121768,
-0.0005770358,
0.009345165,
0.0014992997,
-0.0021177297,
0.0011979496,
0.015789423,
0.009331919,
-0.0028528916,
0.02842626,
-0.037009772,
0.018266454,
0.021352809,
-0.00056461757,
-0.0051494446,
0.011153267,
0.003758598,
-0.0061660875,
0.0051958063,
-0.021683963,
-0.021207102,
0.015656961,
-0.02204161,
0.046785437,
0.022200564,
0.04988504,
-0.0047719292,
-0.0067191147,
0.030545644,
0.023538426,
-0.003210538,
-0.010788997,
0.005242168,
-0.0048547178,
0.016915346,
-0.023233764,
-0.01088172,
0.0024521954,
-0.01589539,
0.005887918,
0.026068442,
-0.020531548,
-0.015233084,
-0.0012989516,
-0.02866469,
-0.048348483,
0.005464041,
-0.005318333,
0.0067025567,
-0.04490448,
-0.009351789,
0.008570265,
-0.011173136,
0.002152501,
-0.015882146,
0.007815234,
-0.02535315,
0.019432116,
-0.00087921385,
0.016292777,
0.02290261,
-0.0055104024,
-0.0022203876,
-0.021167364,
-0.0034638708,
0.043791804,
-0.0022717165,
0.014332345,
-0.012219583,
-0.026161166,
0.0070072184,
-0.0179353,
-0.006457503,
-0.0043877903,
-0.021710455,
-0.0042917556,
-0.012100367,
-0.0016839181,
-0.026704257,
0.0012592131,
0.00982865,
-0.020399086,
0.025167704,
-0.014650253,
-0.012809036,
0.012703068,
-0.027088396,
-0.001281566,
-0.013259406,
0.0070204646,
0.024094764,
-0.015709946,
-0.007921204,
-0.01696833,
0.0044639558,
-0.0037254824,
0.021511763,
0.045858204,
-0.024015287,
-0.028452752,
0.013974698,
0.024690842,
-0.022597948,
-0.025763782,
0.017604146,
-0.0021541568,
-0.0040897517,
-0.002909188,
-0.030015798,
-0.0055666985,
0.016623931,
-0.015855653,
-0.0035069208,
0.011630128,
0.01593513,
-0.031393398,
0.02741955,
-0.01614707,
0.0044672675,
-0.011034051,
-0.00014726004,
-0.015603976,
-0.021670718,
-0.035897095,
0.005801818,
0.000827471,
0.01365679,
0.016637176,
-0.011259235,
0.010583682,
-0.026147919,
0.013987944,
-0.013067337,
-0.02455838,
0.034784414,
-0.0036989902,
-0.00056834304,
0.0196573,
0.015047638,
0.00267738,
-0.0025217377,
-0.01804127,
-0.01421313,
-0.02821432,
-0.015749684,
0.022399256,
0.015736438,
-0.02821432,
0.01924667,
-0.015643714,
0.0053812526,
-0.03348629,
-0.0170743,
0.0025482299,
-0.0365594,
0.0017236565,
0.015286068,
0.021882655,
0.011656621,
-0.0034042632,
0.010630043,
0.008550396,
0.009881635,
-0.018491639,
0.020306364,
0.010418105,
0.024584873,
-0.02055804,
0.002101172,
-0.011199628,
-0.0127560515,
0.005765391,
-0.0034605593,
-0.022200564,
0.014915176,
-0.01324616,
0.0059276563,
-0.0039904057,
-0.025671057,
0.029856844,
0.007292011,
0.017127285,
-0.0046394677,
-0.005447483,
0.0015994738,
-0.003410886,
-0.0069078724,
0.024081519,
-0.024266966,
0.011842066,
-0.012934875,
0.016067592,
-0.010027343,
-0.04212279,
-0.0121732205,
-0.014597268,
0.02335298,
-0.02524718,
-0.01316006,
-0.0007186042,
0.0056958487,
-0.016915346,
0.023538426,
0.019630808,
-0.004470579,
-0.0038115825,
0.011908297,
0.005069968,
0.038758263,
0.0050136717,
0.0058945413,
-0.0019869239,
-0.011610259,
-0.034413524,
0.010623421,
0.0039837826,
0.02111438,
0.022915857,
-0.046758942,
-0.033035923,
0.0017104103,
-0.040877648,
0.00049548916,
-0.012875267,
0.04018885,
0.012915006,
0.006868134,
0.0177631,
0.0020928932,
0.009464381,
0.030360198,
0.01610733,
-0.0095769735,
0.03014826,
-0.013776006,
-0.0024704088,
0.0015266199,
-0.0458847,
-0.020425579,
0.029830351,
0.002741955,
0.01631927,
0.029962813,
0.007987434,
0.010702897,
-0.012391782,
0.01986924,
0.00483816,
-0.0074377186,
-0.012166598,
-0.033565767,
-0.00449376,
0.024823304,
0.010053835,
-0.003361213,
-0.007722511,
0.021551503,
-0.0053083985,
0.001928972,
-0.04132802,
-0.009762419,
0.015007899,
-0.0037685325,
-0.010086951,
0.029936321,
-0.028585212,
-0.006040249,
0.023896072,
-0.003260211,
-0.029883336,
0.018292947,
0.0051593794,
-0.018120747,
0.009351789,
-0.0074244724,
-0.01047109,
0.0023793415,
0.006778722,
-0.019418871,
-0.009100112,
-0.0026591665,
-0.033777706,
0.012921629,
0.00569916,
0.007318503,
-0.015948376,
-0.027048659,
0.00120954,
-0.013749514,
-0.026227396,
-0.011318844,
0.010484336,
-0.020160655,
-0.01514036,
-0.012828906,
-0.024651103,
-0.015272822,
0.01507413,
-0.00888155,
-0.0009330264,
0.028002381,
0.19455959,
0.008464296,
0.005169314,
-0.011385075,
-0.021087887,
-0.016981578,
0.0019057912,
0.005801818,
0.00037606675,
0.003821517,
0.024346441,
-0.009477627,
-0.007941073,
-0.006354845,
0.0065965876,
0.002554853,
-0.0121401055,
-0.015511253,
-0.018597608,
-0.027684474,
-0.02307481,
-0.0046825176,
0.001993547,
0.0006238113,
0.0006084955,
0.0037685325,
-0.0154847605,
0.011106905,
0.031949736,
0.022121087,
-0.013054091,
0.026995674,
0.0051494446,
-0.004960687,
0.017961793,
0.0030797322,
0.0021326318,
-0.02111438,
-0.026743997,
-0.010411481,
-0.008040419,
0.021564748,
-0.02524718,
0.018491639,
-0.019047977,
0.026346613,
-0.00014560427,
-0.019776516,
-0.0061561526,
0.0017882315,
-0.02376361,
-0.0039771595,
0.022227056,
0.023988795,
0.00018606715,
-0.013908468,
0.02062427,
0.029406475,
0.010067081,
0.013802499,
-0.013206421,
0.009497496,
-0.010934705,
0.027207613,
-0.010630043,
0.01582916,
0.0012881891,
-0.00075627293,
0.015113869,
-0.008610004,
0.0068019032,
-0.030784076,
-0.0048216023,
0.03640045,
-0.013199798,
-0.022823133,
0.012378536,
0.028479243,
-0.004980556,
-0.0055766334,
0.013895222,
0.0033512784,
-0.024637857,
0.00757018,
-0.020319609,
-0.03401614,
0.014597268,
0.02628038,
-0.008060289,
-0.0037751556,
0.029379983,
-0.0067522298,
-0.005464041,
-0.0049938024,
0.012312305,
-0.0027816936,
-0.014252868,
-0.0014198228,
-0.010676404,
0.010100197,
-0.03165832,
0.073966555,
0.011961282,
0.0022071414,
-0.00088749273,
0.0022319779,
0.009755797,
0.011709605,
-0.0010182986,
0.00879545,
0.0163855,
-0.016849115,
0.010027343,
-0.008205996,
0.02390932,
0.021405794,
0.003283392,
-0.027048659,
0.024372933,
0.010603551,
0.018173732,
-0.04718282,
-0.02821432,
0.032718014,
0.0022054857,
0.004377856,
-0.00012904657,
0.0034738055,
-0.021577993,
-0.021816425,
-0.0028230879,
-0.002771759,
0.0054243025,
-0.013100452,
0.0021508452,
0.006980726,
0.0024207358,
-0.012994483,
0.0018528067,
0.026638027,
0.0065469146,
-0.008417934,
0.008702727,
-0.0019173817,
0.008345081,
-0.016478224,
0.019511594,
-0.00063747144,
-0.00649393,
-0.032029215,
-0.01324616,
-0.007543688,
0.0044374634,
-0.017484931,
-0.006960857,
-0.029168043,
-0.03287697,
-0.021710455,
0.019736778,
-0.00024774458,
-0.040268324,
0.022306534,
0.0148356985,
0.0024372933,
0.0008216759,
-0.019127455,
-0.16637176,
0.019140702,
0.012510998,
-0.020981917,
0.011067167,
-0.019365886,
0.0030052224,
0.011775836,
-0.019365886,
-0.016306022,
0.030095275,
0.011597013,
-0.036479924,
-0.028108351,
0.009954489,
-0.008941158,
-0.022240302,
0.03274451,
0.02573729,
-0.004705698,
0.00058324495,
-0.021127624,
0.02638635,
-0.0029853533,
0.019047977,
-0.013266029,
-0.01918044,
0.010411481,
-0.008073535,
-0.027128136,
-0.02307481,
0.010457844,
0.036877308,
0.0033761149,
-0.010630043,
-0.0107426355,
0.009523989,
0.012067252,
0.0001879299,
0.02221381,
0.012087121,
0.0025929357,
-0.006987349,
0.0052057407,
-0.0054110563,
0.061727103,
0.012676575,
-0.030333705,
0.017948547,
-0.009292181,
0.011815575,
-0.008166257,
0.011497667,
0.018663839,
0.010888344,
0.0032933266,
0.008755712,
0.0068019032,
-0.005262037,
0.011577143,
-0.004914325,
-0.021723703,
0.002324701,
-0.017127285,
0.024505395,
-0.039341096,
0.022491978,
0.009689566,
-0.018266454,
-0.00025147008,
-0.02731358,
-0.0005695849,
-0.0063813375,
-0.023220519,
0.03229414,
0.012749429,
-0.009437889,
0.018822793,
0.014888683,
0.006361468,
-0.00470901,
0.005815064,
-0.019604316,
-0.009967735,
-0.019445363,
0.034757923,
0.022028364,
0.014067422,
0.013206421,
-0.03632097,
0.0048547178,
-0.030466167,
0.016014608,
-0.006993972,
0.013438229,
0.022823133,
-0.0055203373,
-0.00470901,
0.000046982474,
-0.015961623,
0.035102323,
-0.010285643,
-0.019273162,
-0.008821943,
0.052401807,
-0.019644056,
-0.017604146,
-0.004606352,
0.0375926,
-0.00640783,
-0.0030515841,
0.018663839,
0.019034732,
0.040506758,
-0.0054044332,
0.025922734,
-0.019577824,
-0.012219583,
-0.009451135,
-0.034651954,
0.06866809,
0.008676235,
-0.000059245518,
0.0051130177,
0.0031972919,
-0.0008129831,
-0.1307661,
-0.01150429,
0.0013660103,
-0.01804127,
-0.007530442,
0.0072787646,
-0.0033810823,
0.011219498,
-0.003765221,
0.01838567,
-0.020875948,
-0.03372472,
0.010332005,
0.0031989475,
0.052189868,
-0.009331919,
0.01359056,
-0.0069012493,
-0.018412162,
0.038440354,
0.0058349334,
0.0020150722,
-0.012537491,
-0.012862021,
-0.00008687618,
-0.012358667,
-0.026094934,
0.0014098882,
0.020054687,
0.019458609,
0.0071595493,
-0.021577993,
0.02924752,
-0.0029124995,
-0.02483655,
-0.02638635,
-0.032982938,
-0.019432116,
0.008457673,
-0.027061904,
0.010861851,
-0.0017749855,
0.02348544,
-0.00028686214,
0.0021458778,
-0.007543688,
-0.024028534,
-0.011140021,
0.018981747,
-0.0074112266,
-0.021127624,
-0.016703408,
-0.0051858714,
0.023061564,
0.00967632,
-0.017392207,
0.0074973265,
0.01911421,
-0.019365886,
-0.026743997,
-0.0067356722,
-0.024015287,
-0.027008919,
0.0024058337,
0.011378451,
-0.018544624,
-0.022982087,
-0.036612384,
0.0018594296,
-0.02079647,
-0.035711646,
-0.01514036,
0.0038546326,
-0.014080668,
-0.015034392,
0.001735247,
-0.0027402993,
-0.016239792,
0.012159974,
0.005218987,
-0.026068442,
-0.012603721,
0.056481626,
-0.015683454,
-0.0034605593,
0.031446382,
0.0075635575,
-0.0068548876,
0.001562219,
-0.005666045,
0.002102828,
0.02055804,
0.01359056,
-0.011497667,
-0.0074907034,
-0.016239792,
-0.011709605,
-0.0003758598,
0.02524718,
0.028293798,
-0.0039639133,
-0.025472365,
-0.049858544,
0.013974698,
0.011663244,
-0.027578505,
-0.00640783,
-0.03210869,
0.0160411,
0.00522561,
0.024333196,
-0.006947611,
-0.020491809,
0.0030565513,
0.00679528,
0.010179674,
-0.016650423,
-0.006083299,
0.03274451,
-0.009020635,
0.012497752,
0.01782933,
0.002533328,
-0.016743146,
-0.003549971,
0.0071595493,
-0.019577824,
0.006361468,
-0.022505226,
0.01786907,
-0.006821772,
-0.015815916,
-0.0037321055,
-0.043261956,
-0.005960772,
-0.0037420401,
0.014663499,
0.004702387,
0.008139765,
0.027340073,
0.028134843,
0.033274353,
-0.015113869,
-0.022346271,
0.007152926,
-0.005122952,
-0.0065104878,
0.014451561,
-0.03918214,
0.02638635,
0.010928082,
-0.00004540432,
0.029194536,
0.018716823,
0.011729474,
-0.029432967,
-0.0005074935,
0.0033595574,
-0.013828991,
0.00483816,
-0.014517792,
0.00095786294,
0.03163183,
-0.014358837,
0.010484336,
0.00623563,
0.003947356,
0.0019852682,
0.0120076435,
0.013213044,
0.0044672675,
-0.020597778,
-0.020173902,
-0.0011408256,
0.008576889,
0.0057985066,
0.0010837015,
-0.002425703,
0.006980726,
0.023578165,
-0.0044672675,
0.015776176,
0.001389191,
-0.01270969,
-0.03618851,
-0.002541607,
0.0141204065,
0.011358582,
0.014398576,
0.025127966,
-0.02238601,
0.008133142,
-0.0054011215,
0.010312135,
-0.010113443,
0.028797152,
0.009530612,
0.030890044,
-0.012650083,
-0.028823644,
0.0014140275,
0.028982598,
-0.020491809,
0.0011358582,
0.008934535,
-0.03973848,
-0.0046129753,
-0.0066893105,
-0.034784414,
-0.019418871,
-0.031128475,
0.005556764,
0.02404178,
0.0046659596,
-0.014464807,
0.0013817401,
0.0075900494,
0.0011159889,
-0.007543688,
-0.019233424,
0.0068151494,
0.044560082,
0.008477543,
0.00907362,
-0.0023197338,
0.007815234,
0.024717335,
0.015736438,
0.010497581,
-0.00432156,
0.043818295,
0.00449376,
0.027975889,
-0.01593513,
-0.026677765,
-0.0122063365,
0.017551161,
-0.012895136,
0.0034440015,
0.015233084,
0.00348374,
0.078046374,
0.00031045688,
-0.027684474,
0.012703068,
-0.012941498,
0.028532228,
-0.0035234785,
0.018120747,
0.023776857,
-0.019140702,
-0.00066768925,
-0.01718027,
0.036479924,
-0.027499028,
-0.03812245,
0.0025581645,
0.026041951,
0.027843429,
-0.0029671397,
-0.0041063097,
0.009424643,
-0.03004229,
0.018650593,
0.013067337,
-0.0198295,
-0.008497411,
0.02165747,
-0.027008919,
-0.0065833414,
-0.040824663,
0.013239536,
0.007219157,
-0.028161336,
-0.022319779,
0.011338713,
-0.014663499,
-0.0071661724,
-0.018226717,
-0.006874757,
-0.004119556,
0.00896765,
0.031313922,
-0.0042453944,
-0.014742976,
-0.00033798403,
-0.04750073,
-0.01686236,
-0.0172465,
-0.00043381174
] |
We recently identified a novel mechanism for modulation of the phosphorylation state and function of the N-methyl-d-aspartate (NMDA) receptor via the scaffolding protein RACK1. We found that RACK1 binds both the NR2B subunit of the NMDA receptor and the nonreceptor protein-tyrosine kinase, Fyn. RACK1 inhibits Fyn phosphorylation of NR2B and decreases NMDA receptor-mediated currents in CA1 hippocampal slices (Yaka, R., Thornton, C., Vagts, A. J., Phamluong, K., Bonci | [
-0.021426162,
-0.01791612,
-0.010889261,
-0.04057554,
-0.036564063,
0.00943239,
-0.025613818,
-0.0013857211,
-0.026969047,
-0.002954398,
0.031034732,
-0.008714119,
0.0192849,
0.02040974,
-0.01153977,
-0.012894999,
0.019650813,
-0.007155606,
-0.014053719,
0.001477199,
-0.0022767838,
0.026074596,
-0.015300529,
-0.03453122,
-0.01254264,
0.016642205,
0.009933825,
-0.027389167,
-0.00324069,
-0.01412148,
0.011939563,
0.0076502645,
0.016533786,
-0.0034931013,
0.008632805,
-0.018851228,
-0.013186373,
-0.010225199,
0.0000615676,
-0.0006560153,
0.017983882,
-0.0074876375,
-0.0049804645,
-0.0053700926,
0.0016754012,
-0.0038115801,
0.013003417,
0.0065389774,
-0.030519744,
0.01744179,
0.004709419,
0.011187411,
-0.0031238017,
-0.018539526,
-0.002381814,
-0.026508268,
-0.005034674,
0.0152463205,
0.010225199,
-0.019474633,
-0.021277087,
0.026548926,
-0.025369877,
0.012203832,
0.016506683,
0.021493923,
0.004855106,
0.007663817,
-0.0018600511,
-0.011377143,
0.03753983,
0.017726388,
-0.015043036,
-0.021778522,
0.027538242,
-0.006088364,
-0.0186886,
0.010069348,
-0.009879615,
-0.002851062,
0.0019125661,
-0.022564555,
-0.016506683,
0.043584146,
0.012298699,
-0.009181673,
0.017983882,
0.0046619857,
0.017712835,
0.002427553,
0.015368291,
0.030384222,
0.03195629,
0.016994566,
-0.011783712,
-0.0013484523,
-0.012976312,
0.01399951,
-0.0144060785,
-0.0015026096,
0.0032101974,
0.010475916,
-0.011566875,
-0.018363345,
-0.01767218,
0.006389902,
-0.037919294,
-0.017414685,
0.013870764,
0.012603625,
-0.010584334,
0.016222084,
-0.0039809835,
-0.034422804,
0.017956777,
0.0066440077,
0.016181428,
-0.00925621,
-0.0047907326,
-0.008802209,
0.008151699,
0.026589582,
0.022456136,
0.0029916668,
0.025762893,
0.01614077,
0.0021327909,
0.00006103822,
-0.028676635,
0.0035269822,
0.012027653,
0.018295584,
0.0070810686,
0.00033859536,
-0.012515535,
0.023540318,
-0.013918196,
-0.0062780958,
-0.011112873,
-0.030302908,
-0.009493375,
0.018024538,
-0.03623881,
0.008111042,
-0.016303398,
0.038217444,
0.012630729,
0.010435259,
0.019488186,
0.001526326,
-0.00007983143,
-0.0011451681,
0.004086014,
-0.00398776,
-0.0018651332,
0.0070742927,
-0.019108722,
0.0030628163,
-0.023824917,
-0.016872594,
0.006620291,
-0.0074130995,
0.0016178039,
0.00057088997,
0.052582864,
0.019474633,
0.007426652,
-0.013498075,
0.0014407772,
-0.0031017791,
-0.0008529469,
0.020599473,
-0.02088407,
0.012359683,
-0.005268451,
-0.006281484,
0.01624919,
0.009378181,
-0.03228154,
-0.0025935685,
-0.0002551641,
0.003814968,
0.032118913,
0.012108967,
0.005807154,
0.00857182,
0.040114764,
-0.021453267,
-0.010448812,
-0.012671386,
-0.0024394111,
0.017360477,
-0.005664855,
-0.014419631,
-0.6340301,
-0.02443477,
0.023242168,
0.0166151,
-0.01512435,
0.034504116,
0.02213088,
0.006603351,
0.005461571,
0.0213584,
-0.014853304,
0.023797812,
0.016655758,
-0.022740733,
-0.052067876,
-0.020192904,
-0.0076231603,
-0.008178804,
0.036618274,
-0.0032508543,
-0.019447528,
0.023147302,
-0.017794149,
-0.003482937,
0.02627788,
0.009791526,
-0.0012645975,
-0.014013062,
-0.02627788,
0.018282032,
-0.04645723,
0.021548133,
0.00830755,
0.013660703,
0.048734017,
-0.009452718,
-0.00788743,
0.032444168,
0.0024919263,
0.024692263,
-0.015558023,
-0.0052582864,
0.016276294,
0.018282032,
-0.038217444,
-0.0018736033,
0.016886147,
0.016438922,
-0.00025601112,
-0.025668027,
0.018241376,
-0.011146754,
-0.02527501,
-0.004587448,
0.006115468,
0.013430314,
0.015801964,
-0.002280172,
0.011661741,
0.02639985,
-0.017712835,
0.011519442,
-0.013755569,
-0.017821254,
-0.0222393,
-0.0028849426,
-0.010394602,
0.021426162,
0.011661741,
0.006864232,
0.02271363,
0.024475425,
0.0033999295,
-0.0029222113,
0.01773994,
0.023445452,
0.0124477735,
0.008741223,
-0.025735788,
0.018675048,
0.0074402043,
0.01702167,
-0.028215857,
0.0015297141,
0.022279955,
0.022794943,
-0.003669281,
0.03054685,
0.009195225,
-0.00071615353,
0.00579699,
-0.0070539643,
-0.029815026,
-0.039897926,
-0.030031864,
0.032877844,
-0.0020345368,
0.016913252,
0.007995848,
-0.00353037,
-0.022374822,
0.024245037,
0.00018570865,
-0.03629302,
0.017726388,
-0.006765978,
-0.039653983,
0.01839045,
0.052718386,
-0.02408241,
-0.003145824,
-0.018051643,
0.00045950714,
-0.003855625,
0.006366186,
-0.036021974,
0.02705036,
-0.0055564367,
0.008951284,
-0.037051946,
-0.0052752267,
-0.008463401,
0.011519442,
0.00020106084,
0.01227837,
0.012759476,
-0.002093828,
-0.00004875646,
-0.02064013,
0.012712043,
0.0076976977,
-0.0015415724,
0.04258128,
-0.01512435,
0.041551303,
-0.00064542756,
0.02425859,
0.008239789,
0.012420669,
-0.05773273,
-0.035208836,
-0.0046348814,
0.0022700077,
-0.024448322,
-0.0058308705,
-0.002048089,
-0.0146635715,
0.0091342395,
0.01106544,
0.013918196,
0.012908551,
0.021128012,
-0.0140401665,
0.0010062571,
0.014961722,
-0.02984213,
-0.017455343,
-0.0056784074,
0.009283315,
-0.004624717,
0.006379738,
-0.00073902303,
-0.029679503,
0.010306512,
-0.005810542,
-0.030980522,
0.020125143,
0.006091752,
-0.008883523,
-0.031712346,
-0.00023420042,
-0.027971916,
-0.034720954,
-0.0006094293,
0.001090959,
0.010320065,
0.012468101,
-0.00523457,
-0.017807702,
-0.0017550208,
-0.019623708,
-0.014162137,
-0.015612232,
-0.0014915983,
0.019447528,
0.019054512,
0.030004758,
0.005227794,
-0.009208777,
0.026779315,
-0.037160363,
0.012373236,
-0.0160188,
0.012095414,
-0.009981258,
-0.040792376,
0.027091017,
0.0021548131,
-0.019068064,
0.032146018,
-0.015083693,
-0.01387754,
0.006190006,
0.0004899998,
0.009351077,
-0.01020487,
-0.005017733,
-0.0166151,
-0.0010867239,
0.016777728,
0.004292686,
-0.0024851502,
0.008415969,
-0.03304047,
-0.013606493,
0.007670593,
-0.012976312,
0.011499113,
-0.02230706,
-0.025058175,
0.010564006,
-0.0034050115,
0.03482937,
0.01029296,
-0.00075426936,
0.002049783,
-0.011783712,
0.04751431,
0.0069319936,
-0.008327879,
-0.0050685545,
0.01566644,
0.009215553,
0.019244244,
-0.0018481928,
0.0010189624,
0.002527501,
-0.004824613,
0.042852324,
0.017807702,
0.0026054268,
0.0011358509,
-0.008917403,
0.014487392,
0.0032356079,
-0.007670593,
0.009947377,
0.027551794,
0.009174896,
0.015883278,
-0.0037946396,
0.019921858,
-0.0015432665,
0.013220253,
-0.008266893,
-0.015273425,
0.0195695,
0.016506683,
0.032010496,
0.028324274,
-0.005055002,
0.018268479,
0.0037810875,
-0.015395395,
0.000006230213,
0.0032118915,
0.014378974,
-0.01055723,
-0.0108553795,
-0.004434985,
-0.0213584,
0.013640375,
0.0044553136,
-0.011682069,
0.009100359,
-0.010326841,
0.01210219,
0.0060646473,
0.013470971,
0.029354248,
-0.026142357,
-0.025003966,
0.027240092,
0.0154225,
-0.004363836,
-0.016628653,
-0.02520725,
0.0048415535,
-0.012373236,
-0.00029412692,
-0.006139185,
0.015165007,
-0.012217385,
-0.010164213,
-0.014514497,
-0.00618323,
0.033121783,
0.002144649,
0.0059765577,
-0.029625295,
0.016344056,
0.010367498,
-0.0042012082,
-0.0030204654,
0.012217385,
0.0005090577,
0.00779934,
-0.0007225062,
0.004170716,
-0.01814651,
0.031576823,
0.0054276898,
0.013464195,
-0.02568158,
-0.0035405343,
0.018702153,
-0.010774067,
-0.007419876,
0.012468101,
0.014053719,
-0.005895244,
-0.0055022277,
0.0044959704,
-0.0029764206,
0.024895547,
0.01046914,
-0.008754776,
0.00676259,
-0.0031746228,
0.00246821,
-0.02485489,
-0.01507014,
0.029815026,
-0.0021310968,
-0.019312005,
-0.010008362,
0.014311212,
0.022320613,
0.01832269,
0.010523349,
-0.008883523,
0.0034541385,
0.0086395815,
-0.010618215,
0.02740272,
0.0038861176,
0.008239789,
0.03173945,
0.025424086,
0.0065423655,
0.016086562,
0.02325572,
0.00219547,
-0.02995055,
0.028839262,
-0.0024512694,
-0.0018295584,
0.010367498,
-0.0034863253,
-0.028514007,
-0.0055903173,
0.01287467,
0.0024427993,
0.03190208,
0.020396188,
-0.0042757457,
0.010272631,
0.007467309,
-0.004628105,
0.0030390997,
0.0160188,
-0.021155117,
-0.010719857,
-0.013247359,
0.02313375,
-0.0073317857,
-0.0045976127,
-0.002566464,
0.019054512,
-0.008293998,
0.007311458,
-0.0033457202,
-0.008470178,
0.0004569661,
-0.019176483,
0.00009650709,
0.0036049078,
-0.014243451,
0.004374,
-0.017238505,
-0.007392771,
0.004601001,
-0.0070200833,
-0.017577313,
0.019542394,
-0.019433975,
-0.02508528,
0.0064102304,
0.02894768,
0.026698,
0.017428238,
-0.005946065,
0.0052887793,
0.023865573,
-0.017116535,
0.006084976,
-0.02900189,
-0.03482937,
-0.018932542,
-0.013145716,
0.019257797,
-0.03599487,
0.011695622,
-0.0029289876,
0.0126849385,
-0.017726388,
0.04561699,
-0.02461095,
-0.010516573,
-0.0023021942,
0.02747048,
0.0019701633,
0.007989072,
0.0011417799,
0.002376732,
-0.0071352776,
-0.01025908,
-0.015192111,
-0.01851242,
-0.012901775,
0.01352518,
0.0091342395,
-0.0051634205,
-0.007934863,
-0.006799859,
-0.0013662397,
-0.01313894,
0.014921065,
0.022456136,
0.014324765,
-0.0035845793,
0.017834807,
-0.01702167,
-0.009107135,
0.011133201,
-0.00447903,
0.03892216,
0.004489194,
-0.028270066,
0.014961722,
-0.0035676388,
-0.0051058233,
-0.02028777,
0.017292716,
0.0057393927,
0.02081631,
-0.0014263779,
-0.026359193,
-0.023038885,
-0.0069794264,
-0.036753796,
-0.016520236,
-0.0028053229,
-0.006098528,
-0.014080823,
-0.009554361,
0.0033931532,
-0.012359683,
0.010333617,
-0.03043843,
-0.024421217,
0.013572613,
-0.014189242,
0.020314874,
-0.03293205,
0.014107929,
-0.04038581,
-0.01679128,
-0.018254928,
-0.02348611,
0.015693545,
0.0016279682,
0.007873877,
0.026670896,
0.04027739,
0.013972405,
0.005698736,
-0.000690743,
0.009838958,
-0.0144060785,
-0.0081449235,
0.015395395,
-0.029923445,
0.023621632,
0.009466271,
-0.010475916,
0.026426954,
0.0012010712,
0.024177276,
-0.003100085,
0.01313894,
-0.018295584,
0.010550453,
-0.015097245,
-0.020314874,
0.021399057,
-0.03344704,
-0.018309137,
-0.031766556,
-0.0018007598,
0.01284079,
-0.008070385,
0.011085769,
-0.042635486,
0.009838958,
-0.035859346,
0.008687015,
0.012549415,
0.025966177,
0.008646358,
-0.008903851,
0.008720895,
0.001671166,
0.0148804085,
0.016926803,
0.0023242168,
0.007243696,
0.007961967,
-0.01076729,
0.0008792045,
-0.013667479,
0.011167083,
-0.020369085,
-0.03114315,
-0.014758438,
-0.015056588,
-0.0023021942,
-0.040440015,
0.0061493493,
0.02574934,
-0.02585776,
0.011146754,
-0.00123834,
0.0080161765,
0.030167386,
-0.020558815,
0.030926313,
-0.020382635,
-0.007616384,
0.024949756,
0.0013255829,
-0.031631034,
-0.024990413,
-0.00493642,
0.00022424795,
0.05244734,
0.020775652,
-0.024922652,
-0.013213477,
0.0019718574,
-0.0046924786,
0.0009859287,
-0.04781246,
0.00904615,
-0.004350283,
0.008998717,
-0.0027358674,
-0.019027408,
-0.0049262554,
0.005949453,
-0.0059325127,
-0.011356815,
-0.021968253,
-0.024705814,
-0.031224463,
0.019474633,
0.0055937055,
0.024814233,
0.022171538,
-0.02747048,
0.01696746,
0.0065084845,
0.00094103673,
-0.004963524,
-0.024123067,
0.04610487,
0.012224161,
-0.021521028,
0.00042287362,
0.004587448,
0.012596848,
-0.013281239,
-0.0076909214,
0.032227334,
-0.0037201021,
0.003091615,
0.009229106,
0.015354739,
-0.010672424,
-0.01245455,
0.003045876,
-0.01624919,
-0.034666743,
-0.0021514252,
0.02385202,
-0.02562737,
-0.018580182,
0.006728709,
-0.015381843,
-0.012617177,
-0.020477502,
-0.0029611741,
-0.0027731361,
-0.055130694,
-0.005563213,
0.005857975,
0.008050057,
0.014636467,
-0.013958853,
-0.006660948,
0.012095414,
0.012847566,
-0.026562478,
0.005658079,
0.0043299547,
-0.007846773,
-0.01761797,
0.00020561357,
-0.028405588,
-0.024272142,
0.011702398,
-0.012271593,
-0.016953908,
0.008422744,
-0.0006060412,
0.02153458,
0.020965384,
-0.008565044,
0.036835108,
0.006613515,
0.0013704748,
0.02415017,
-0.015883278,
0.021128012,
-0.028405588,
-0.00094950694,
0.017211402,
-0.02051816,
-0.020314874,
0.014135033,
-0.041144736,
0.010801171,
-0.025491847,
0.0025867922,
-0.020084485,
0.0011180635,
-0.018105851,
0.0026088147,
0.014541602,
-0.012481654,
-0.019081617,
0.018417554,
0.012000548,
-0.005614034,
-0.006799859,
-0.007839996,
-0.0003714173,
-0.01150589,
-0.0219547,
-0.0016550728,
0.026074596,
-0.040358704,
-0.042174708,
0.003919998,
-0.026779315,
0.03932873,
-0.0036997737,
-0.014365422,
0.0057461686,
0.00714883,
-0.055726994,
0.013891092,
-0.022944018,
0.01180404,
0.008646358,
0.011173858,
-0.016371159,
-0.010353945,
-0.0004177915,
0.02859532,
0.015015932,
-0.012671386,
0.021968253,
-0.0029899727,
0.01566644,
0.007995848,
-0.023973992,
-0.0074402043,
0.028839262,
-0.019664366,
-0.0062476033,
0.023716498,
-0.022876257,
-0.0064508873,
-0.013443867,
-0.0018278644,
0.0025427474,
0.021453267,
0.018729256,
-0.01927135,
-0.0061629014,
-0.0033931532,
0.015937487,
-0.019406872,
0.0060544834,
0.0016135689,
-0.009940601,
0.014622916,
-0.0019684692,
-0.0075825034,
0.011790488,
0.0013941913,
0.025708685,
0.014053719,
0.0056445263,
0.01412148,
0.008504058,
-0.015829068,
-0.007507966,
0.0071759345,
-0.03927452,
0.012522311,
0.0029798085,
-0.0088970745,
0.017292716,
0.015151454,
0.011648188,
-0.01803809,
-0.00063229876,
0.007507966,
0.007128502,
-0.0061629014,
0.010848604,
-0.011018007,
-0.02485489,
-0.007663817,
-0.0019769396,
0.0035100416,
-0.005895244,
-0.010665648,
0.00779934,
-0.02497686,
-0.01791612,
0.019406872,
-0.021521028,
-0.009296867,
-0.01046914,
-0.01124162,
-0.00551578,
0.019908305,
0.19764651,
-0.0051193754,
-0.009188449,
-0.0071081733,
0.008287222,
-0.0015364903,
-0.0013255829,
-0.017008116,
-0.0076231603,
-0.024475425,
0.011051888,
0.02959819,
-0.019705022,
-0.008903851,
-0.0105978865,
0.019501738,
-0.02153458,
-0.016981013,
-0.025789998,
-0.0015576658,
0.037404306,
0.0017033528,
0.012000548,
0.009073255,
0.053667046,
0.0052040773,
-0.0140401665,
-0.006467828,
-0.005088883,
0.003615072,
-0.028974785,
0.0036387884,
0.017048774,
-0.0063492456,
-0.017496,
0.008856418,
-0.008029728,
-0.015693545,
0.029543981,
0.014500945,
-0.006854068,
-0.0009910108,
0.0010926529,
0.0067354855,
-0.016222084,
-0.004946584,
0.00092240237,
-0.029327143,
-0.0070675164,
0.014826199,
-0.046294603,
0.0011146754,
0.0066880523,
0.020423293,
0.015747754,
-0.01856663,
-0.0025969564,
0.039139,
-0.0073588905,
0.05551016,
-0.035452776,
0.0033694368,
-0.023160854,
0.022618763,
-0.027863497,
0.008693791,
-0.018241376,
0.013023745,
0.032959156,
-0.016452473,
-0.0072098156,
0.0036354004,
-0.0047873445,
-0.024109514,
-0.011322934,
-0.00058740686,
0.03694353,
0.022374822,
0.021453267,
0.028080333,
-0.008734448,
0.014365422,
-0.009703436,
-0.007047188,
-0.0033050634,
-0.028920576,
0.018227823,
0.0063627977,
-0.00753507,
-0.012244489,
0.012651058,
0.002912047,
-0.02859532,
-0.0132880155,
0.004099566,
0.0007305528,
0.019718574,
-0.00771125,
-0.00779934,
0.0071623824,
-0.022930466,
0.06087686,
0.00579699,
0.0057902136,
-0.022510344,
-0.009364628,
-0.002197164,
0.03404334,
-0.004563732,
-0.030926313,
0.007602832,
-0.01465002,
0.007880653,
-0.02538343,
0.008734448,
0.0025935685,
-0.00040423925,
-0.009879615,
0.032742318,
-0.011654965,
-0.01660155,
-0.041226048,
-0.0030882268,
0.018729256,
-0.00068311987,
0.01206831,
0.0058986316,
-0.0056377505,
0.017496,
-0.047649834,
0.021615895,
-0.0055801533,
0.006328917,
0.0018397226,
0.007589279,
-0.010875708,
0.016086562,
-0.012854342,
0.011390695,
0.01326091,
-0.016100114,
0.00848373,
0.016628653,
0.011986996,
0.0019701633,
-0.010150661,
0.017496,
0.019122273,
-0.0069726505,
0.0057800496,
-0.013830107,
-0.001096888,
0.014514497,
-0.014893961,
0.0051159873,
-0.020870518,
-0.0150294835,
-0.04775825,
-0.026264327,
0.00627132,
-0.030655269,
-0.007528294,
0.014067272,
-0.01097735,
-0.004424821,
0.010618215,
-0.17227665,
0.014853304,
0.029164517,
-0.029625295,
0.021859836,
0.0073453384,
0.031116046,
0.0019667754,
-0.024041753,
0.003950491,
0.0044688657,
0.006383126,
-0.01624919,
-0.022984674,
0.01666931,
0.008632805,
-0.01124162,
-0.0010062571,
0.0025952626,
0.014162137,
0.0068337396,
-0.012264818,
0.030899208,
-0.015788412,
0.0019701633,
0.010801171,
-0.0150294835,
-0.0073724426,
-0.006992979,
-0.010970575,
-0.008802209,
-0.002142955,
0.03648275,
-0.011865025,
0.035913553,
0.016452473,
0.009764421,
0.008151699,
0.0037912517,
0.02390623,
0.021724312,
0.039410044,
0.0043435073,
-0.0013044074,
-0.015869725,
0.021155117,
0.007853549,
0.0013848741,
0.0015407254,
-0.017929673,
0.028514007,
-0.007562175,
0.020558815,
0.0062103346,
0.044451494,
0.023038885,
0.005868139,
0.01881057,
-0.004861882,
-0.0069862027,
-0.00806361,
-0.006423783,
0.032118913,
-0.006420395,
-0.011289053,
-0.013775897,
-0.019583052,
-0.016181428,
-0.023865573,
-0.0025834043,
-0.009371405,
-0.011966667,
0.018783467,
-0.0056919595,
-0.007467309,
0.024841338,
0.010909589,
-0.0066372314,
0.0061120805,
0.016466025,
0.0014407772,
0.005614034,
-0.032173123,
-0.025898416,
-0.005807154,
-0.0061798417,
0.024583844,
0.0146635715,
-0.0067354855,
0.0015449604,
0.008741223,
-0.049574256,
0.022198642,
-0.0040927897,
0.024827786,
0.00026299903,
0.017130088,
-0.0012569744,
0.005326048,
0.009147792,
0.006383126,
-0.005949453,
-0.02740272,
0.0004904233,
0.040250286,
-0.010611439,
-0.0041605514,
0.017685732,
0.043042056,
-0.017333372,
0.013450642,
-0.0030119952,
0.02295757,
0.028839262,
-0.007724802,
0.014189242,
0.0061188564,
-0.012596848,
-0.006325529,
0.0058274823,
0.06477992,
0.010028691,
0.010462364,
0.021141564,
0.00062213454,
-0.024814233,
-0.118175924,
-0.03417886,
0.008592148,
-0.009635675,
-0.02385202,
0.0020701115,
0.014541602,
0.025735788,
-0.007928086,
0.039653983,
-0.041388676,
0.0057868254,
0.0057326164,
-0.003909834,
-0.00038878116,
0.00656947,
0.0385427,
-0.013376105,
-0.010868932,
0.02242903,
0.0006513567,
-0.00088005146,
-0.0011773547,
-0.0075418465,
-0.005661467,
-0.004895763,
-0.01494817,
0.02023356,
0.00458406,
0.019000303,
0.016520236,
-0.020802757,
0.02645406,
0.005434466,
-0.028785052,
-0.010665648,
0.0054276898,
-0.02148037,
0.02503107,
-0.013762345,
0.0032051152,
-0.008172028,
0.04835455,
0.010862156,
-0.009290091,
0.005282003,
-0.018105851,
0.02248324,
0.018661495,
0.011444904,
-0.014500945,
-0.018024538,
-0.013396434,
-0.011695622,
0.02545119,
-0.024787128,
-0.009147792,
0.022496792,
-0.025234355,
0.00075977494,
-0.0030712865,
0.023120198,
0.007365667,
-0.021819178,
0.0326339,
-0.0026969046,
-0.004211372,
-0.048598494,
0.02984213,
-0.0013094895,
0.0058308705,
0.02480068,
-0.021710759,
-0.008707343,
-0.029056098,
0.014053719,
-0.03447701,
-0.021304192,
0.0014484004,
-0.0065254252,
-0.032715216,
-0.017943224,
0.003037406,
-0.017807702,
0.027334958,
0.004963524,
0.0025105607,
-0.005702124,
0.006904889,
-0.016384711,
-0.008341432,
0.019176483,
0.0043706116,
0.015232768,
-0.0013094895,
0.01257652,
-0.008470178,
0.021033145,
-0.0069015007,
0.034992,
-0.022523897,
-0.020314874,
-0.06765301,
0.008280446,
0.013809778,
-0.011709174,
0.011621084,
-0.014677124,
0.0034897132,
-0.008585372,
-0.000073108225,
-0.0038725652,
-0.031495508,
0.0020684174,
-0.013742017,
0.0061595133,
-0.029435562,
-0.00562081,
0.049980827,
-0.024407664,
0.014392526,
0.035290148,
-0.01974568,
-0.012169952,
0.0126849385,
0.018607287,
-0.0066507836,
-0.0073724426,
-0.026738657,
0.008517611,
0.0120615335,
0.019054512,
0.006627067,
-0.048842434,
-0.0048415535,
-0.0002761278,
-0.0036963855,
-0.02824296,
-0.0073317857,
0.019826991,
0.004892375,
0.01844466,
-0.0024156948,
-0.052582864,
0.0063085887,
-0.03518173,
0.0039708195,
-0.019135825,
-0.04786667,
-0.00023250638,
-0.010414931,
-0.02532922,
0.008239789,
0.0081449235,
-0.0054107495,
-0.016560892,
-0.024963308,
0.005908796,
-0.0032593245,
-0.015625784,
-0.034422804,
-0.028405588,
0.007914534,
0.016953908,
0.014094376,
-0.011709174,
-0.0074876375,
0.0007945027,
-0.0361846,
0.021737864,
0.011485561,
-0.015991695,
-0.03374519,
0.014446735,
0.034992,
0.008626029,
-0.004949972,
-0.012434221,
-0.009656003,
-0.007704474,
-0.03648275,
0.00081356056,
0.026955495,
-0.012908551,
-0.016818386,
0.018783467,
-0.010286184,
-0.012332579,
0.017699284,
0.007629936,
0.0073859952,
0.015354739,
0.0074876375,
0.01494817,
0.025844207,
0.0062035583,
0.018851228,
0.01856663,
0.0020040441,
-0.022564555,
0.018227823,
0.027456928,
-0.016303398,
-0.004014864,
-0.0005082107,
-0.025952624,
0.020328427,
0.023025332,
-0.029354248,
-0.03512752,
-0.016371159,
-0.010950246,
0.011465233,
0.005712288,
-0.012596848,
0.0018498868,
-0.013328671,
0.010807947,
0.009716988,
-0.008002624,
-0.008178804,
0.011255172,
0.014921065,
0.0058783037,
0.0047297473,
-0.012258042,
0.012420669,
0.011018007,
0.018404003,
-0.001236646,
0.02146682,
-0.018702153,
0.01266461,
0.010320065,
-0.033474144,
-0.010110004,
-0.01631695,
-0.008253342,
-0.015937487,
0.014636467,
-0.01696746,
0.09085452,
0.014961722,
-0.012440997,
0.00054632645,
0.003003525,
0.013653927,
-0.010550453,
-0.005857975,
-0.017428238,
-0.038081918,
0.02194115,
-0.014460288,
0.013904644,
-0.018878333,
0.0046924786,
0.019027408,
0.007718026,
0.018105851,
-0.0031932571,
-0.024597397,
0.0059867217,
-0.014500945,
0.0024140007,
0.0075553986,
-0.00857182,
0.008842866,
0.023065988,
-0.007765459,
-0.0064712157,
-0.042174708,
-0.0031322718,
-0.0023547094,
-0.03168524,
0.0057055117,
0.002566464,
-0.0105978865,
-0.007718026,
-0.0048991507,
0.0021683655,
0.01666931,
-0.010110004,
0.00094950694,
-0.01814651,
-0.035263043,
0.017062327,
0.00055776123,
-0.007718026,
-0.017157191,
-0.033474144
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.