text
stringlengths 174
850
| embeddings_A
sequence |
|---|---|
The psychoactive constituent of cannabis, Δ9-tetrahydrocannabinol, produces in humans subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous cannabinoids may contribute to the control of emotion. But the variable effects of Δ9-tetrahydrocannabinol obscure the interpretation of these results and limit the therapeutic potential of direct cannabinoid agonists. An alternative approach may be to develop drugs that amplify the effects of endogenous cannabinoids by preventing their inactivation. Here we describe a class of potent, selective and systemically active inhibitors of fatty acid amide hydrolase, the enzyme responsible for the degradation of | [
-0.035276525,
-0.015446682,
0.0021486732,
-0.027381554,
-0.028464142,
0.005868419,
-0.016780114,
-0.0014712304,
-0.010502423,
0.007881769,
-0.004191728,
0.0070632263,
-0.008040196,
0.00881253,
-0.028252905,
0.0311046,
0.053865355,
-0.011149336,
-0.015684323,
-0.0037296475,
-0.016252022,
-0.021242488,
0.004571294,
-0.013050466,
-0.033322588,
0.020252317,
0.03437877,
-0.055396818,
-0.006541736,
-0.018641638,
-0.0023467075,
0.01998827,
-0.022628728,
0.0006766175,
0.01048262,
-0.0120933,
-0.00041257162,
0.0014671048,
0.024054576,
0.01272701,
0.02684026,
-0.005835413,
-0.010086551,
0.009670679,
0.0074989023,
0.0053073214,
-0.0010611343,
-0.015288254,
-0.02269474,
0.012931645,
0.019684618,
0.047449037,
-0.019275347,
-0.000915909,
0.010040344,
-0.0067991805,
-0.015024208,
0.018232366,
0.015248648,
-0.011433185,
-0.010231776,
0.011307763,
-0.025942504,
0.012231924,
-0.0057925056,
0.009974332,
0.007597919,
0.016172808,
0.025480425,
0.0045778947,
0.0071556424,
0.022193054,
-0.009241604,
-0.0037065435,
0.009947928,
-0.0022443896,
-0.027909646,
-0.011545405,
0.016714102,
0.008258034,
0.031131005,
-0.014139655,
-0.036279898,
0.027170317,
0.02043715,
0.0040828087,
0.0050267726,
-0.00094478903,
0.025031546,
-0.028992234,
0.00022567669,
0.023315249,
0.00052272825,
0.03121022,
-0.022166649,
0.021229286,
-0.0011527252,
0.023473676,
-0.020463552,
-0.031078197,
-0.0022740948,
0.012099901,
-0.010720261,
-0.019512989,
-0.007413087,
-0.0023186526,
-0.009168992,
0.013690777,
0.009327419,
-0.007736543,
-0.000840821,
0.02740796,
-0.0270647,
-0.04538948,
-0.011868861,
0.020054283,
0.004515184,
-0.0016791666,
0.0052149054,
-0.006785978,
-0.0023120514,
0.026048122,
0.026193349,
-0.0022509908,
0.005822211,
0.013043865,
0.01750624,
-0.003312125,
-0.0155390985,
-0.015156232,
0.015525896,
0.017585453,
0.018271973,
0.008310843,
-0.025295593,
0.010951301,
-0.013109876,
-0.022430696,
-0.038154624,
-0.039078787,
0.024939131,
0.016489662,
-0.036834396,
0.019314954,
-0.012106502,
0.021268893,
0.024859916,
0.032979324,
0.00881253,
0.0023302047,
0.014588533,
-0.0055317604,
-0.025982112,
0.0026421088,
-0.0071820472,
-0.0041488204,
0.00049343565,
0.0022757452,
-0.008713513,
-0.012733611,
0.009433038,
-0.042088907,
-0.012443161,
-0.0065285335,
0.037758555,
0.023077607,
0.01825877,
-0.012014086,
0.016846124,
-0.0031239924,
-0.005132391,
0.028490547,
-0.004561392,
0.023275642,
-0.030708533,
0.0060037426,
-0.0026866666,
0.013519147,
-0.0155390985,
-0.027487172,
-0.005403038,
0.024292218,
0.031474266,
0.014944995,
0.0016073791,
-0.03311135,
0.032002356,
-0.01629163,
0.0063337996,
-0.028490547,
-0.0076639308,
0.005247911,
-0.012852431,
-0.029705158,
-0.6311752,
-0.016252022,
0.020054283,
-0.036464732,
0.0022146846,
0.028728189,
0.011862259,
0.0080666,
-0.007756347,
0.005086183,
-0.0058750203,
0.030682128,
0.023948958,
-0.043725993,
-0.008845536,
-0.0024061177,
-0.019856248,
-0.042300146,
0.012852431,
0.00041937907,
0.0075583123,
0.017427025,
-0.022562718,
-0.018588828,
0.020806814,
0.001341683,
0.025876492,
-0.0013326064,
-0.006951007,
0.026576214,
0.007307469,
0.024437442,
0.0096112685,
0.025995314,
0.056188956,
0.017057361,
-0.010086551,
0.022232661,
-0.0032378621,
0.03540855,
-0.0085880915,
-0.027513577,
0.017083766,
-0.00955846,
-0.027856836,
0.021796985,
0.032688875,
-0.007512104,
0.01289864,
-0.02983718,
0.006386609,
-0.0077959537,
0.02113687,
-0.005274316,
0.012344143,
0.0033269776,
0.03334899,
-0.0047561256,
0.009829107,
0.01981664,
0.014086846,
0.033639442,
-0.012997657,
-0.007967584,
-0.03506529,
0.015341064,
-0.025506828,
0.0034986075,
0.004832039,
0.030206844,
0.004917854,
0.027645601,
0.00073850324,
-0.035382144,
0.020516362,
0.019671416,
0.023288844,
-0.01860203,
-0.01543348,
0.023632104,
0.014430106,
0.0036768385,
-0.041270364,
0.000024831656,
0.032345615,
0.015657919,
-0.0041191154,
0.007413087,
0.0036834395,
-0.0014423504,
0.016001178,
0.020595577,
-0.021519737,
-0.031289432,
-0.022628728,
0.010687255,
-0.028147288,
0.014548926,
0.009532055,
0.001871425,
-0.013116477,
-0.013585159,
-0.009162391,
-0.013512546,
0.021123668,
0.0010322542,
-0.014232071,
0.008607894,
0.067490116,
-0.025704863,
0.0067364695,
-0.016568877,
-0.006139066,
0.0025678459,
0.021414118,
-0.025586043,
0.0043732594,
0.007188648,
-0.0088587385,
-0.02441104,
0.02021271,
-0.0011279709,
0.0010339045,
-0.03311135,
0.0167009,
0.017427025,
-0.0032593159,
-0.023777328,
-0.030127632,
-0.008112809,
0.02269474,
-0.0007937878,
0.0059641358,
-0.0044755773,
0.014720556,
-0.0015487939,
0.0022790458,
0.004181826,
-0.002090913,
-0.039157998,
-0.021321703,
-0.010198771,
0.0057528988,
0.008126011,
-0.0004041139,
-0.011875462,
-0.020252317,
0.0053436277,
-0.002874799,
0.004386462,
0.006924602,
-0.0038550694,
-0.0071622436,
0.02199502,
0.03311135,
-0.01993546,
-0.007578116,
0.0076573296,
0.0028401432,
0.00949905,
0.009565061,
0.0015570454,
0.010106355,
0.011136133,
-0.0178495,
-0.03794339,
0.011208747,
0.0072942665,
-0.01255538,
-0.024463847,
-0.016450057,
-0.023856543,
-0.01773068,
0.005832113,
0.0077959537,
0.01596157,
-0.003888075,
-0.02730234,
-0.0021354707,
-0.011882063,
-0.007861965,
-0.002033153,
-0.012363947,
-0.008898345,
0.015459884,
-0.014575331,
0.016846124,
0.024450645,
0.0032411627,
0.010971105,
0.005033374,
0.024886321,
0.011083324,
0.020120293,
-0.014852579,
0.00043691337,
0.01969782,
0.002787334,
-0.0027114209,
0.050723206,
0.013083472,
-0.02055597,
0.008145815,
-0.012271531,
0.006040049,
-0.024873119,
-0.020912431,
-0.01416606,
0.013915217,
-0.007974184,
-0.009677281,
-0.002637158,
-0.014139655,
0.01284583,
-0.0031371948,
0.0123177385,
-0.018707648,
0.004871646,
0.007690335,
-0.0017096968,
0.017585453,
-0.021453725,
0.014641342,
0.0032081571,
-0.0062677884,
0.016674494,
0.023830138,
0.011248353,
-0.018536018,
-0.008561687,
-0.000088806046,
-0.014720556,
-0.011769843,
0.019961866,
-0.00094643934,
-0.00771674,
0.02148013,
-0.016714102,
0.040847894,
0.02441104,
-0.0004303122,
0.04042542,
0.013743586,
-0.0061489674,
0.01526185,
0.016423652,
0.016740507,
0.014509319,
0.00984891,
0.00084577186,
0.012106502,
-0.011670826,
-0.0074328906,
-0.024397837,
-0.0051818998,
0.0028896518,
0.011868861,
0.024569467,
0.03598945,
0.022773955,
0.007677133,
-0.013037263,
0.0033434806,
-0.02269474,
0.0015388922,
0.011373775,
-0.0016181059,
0.0040002945,
-0.011070122,
-0.016964946,
-0.0013425081,
-0.015486289,
-0.017057361,
-0.027698409,
0.028886616,
0.012245126,
0.012608189,
-0.0045976983,
0.007446093,
0.011472792,
-0.013888812,
-0.016555674,
0.031764716,
0.026932677,
0.01923574,
-0.027592791,
-0.011822653,
0.0073404745,
0.01365117,
0.010726863,
-0.0056043733,
0.010627845,
0.028543357,
-0.009479246,
-0.020173103,
0.005000368,
0.027460769,
0.00754511,
0.025018344,
-0.012449762,
0.006310696,
0.0006431992,
-0.012502571,
0.002033153,
0.019565796,
0.020991644,
-0.0059047253,
-0.00029478243,
-0.000077460325,
-0.014641342,
0.017347813,
0.023328451,
-0.01767787,
-0.0041653235,
0.0056637833,
0.0213085,
-0.018470006,
0.0032510646,
0.01740062,
-0.017691072,
0.0038715722,
-0.043514755,
-0.0046340046,
-0.0066968626,
0.03466922,
-0.010060146,
-0.022298671,
-0.0155390985,
0.026523406,
-0.00811941,
-0.031421456,
-0.027539982,
-0.0014043938,
-0.0030777843,
-0.025427615,
-0.022047829,
-0.005713292,
0.00079502555,
-0.00048353395,
-0.000036228947,
-0.011954675,
-0.026681833,
0.0017377518,
-0.007941179,
0.0116576245,
0.020529564,
0.0027675305,
0.028041668,
0.035276525,
-0.0022955486,
-0.0006217455,
0.039554067,
0.015129827,
-0.006069754,
-0.005861818,
0.00984891,
-0.008621097,
0.0033649344,
-0.0029045043,
-0.019394167,
0.0077431444,
0.005373333,
0.022021424,
0.008264635,
0.015591907,
0.034141127,
0.014350892,
0.0003622379,
-0.0143640945,
-0.00817882,
0.0104232095,
0.00368674,
-0.009670679,
-0.0017542546,
-0.004716519,
-0.026761046,
-0.017770285,
-0.022681538,
0.009182194,
-0.033745058,
0.006601146,
-0.010145961,
0.0036702373,
-0.0036768385,
0.006571441,
-0.022034626,
0.012852431,
-0.011426584,
0.016278427,
-0.008403259,
-0.0131296795,
0.0022823464,
0.028728189,
-0.00059534085,
0.0016890683,
-0.009036969,
-0.020661587,
0.0077035376,
0.01071366,
0.023724519,
0.0027229728,
-0.0022839967,
0.013090073,
0.015789941,
-0.00357122,
-0.01635764,
-0.007043423,
-0.016648091,
0.0063800076,
0.000040612522,
0.04002935,
-0.017387418,
-0.016740507,
0.013690777,
-0.0023978665,
-0.0270647,
0.026998688,
-0.0057000895,
0.00009762476,
0.0031668998,
0.01767787,
0.016199213,
0.014496117,
-0.025321996,
-0.017479835,
-0.015077018,
-0.0062578865,
-0.008324046,
0.012165912,
-0.020423947,
-0.0059212283,
0.012575183,
0.018681243,
-0.012885437,
0.003439197,
-0.0055086566,
-0.02689307,
-0.0076507283,
0.01986945,
0.010390204,
-0.014232071,
0.03754732,
0.0028120882,
-0.0070170183,
0.001497635,
-0.019790236,
0.019711023,
0.0028005363,
-0.030127632,
-0.011908468,
-0.0035085091,
-0.002574447,
-0.0062413835,
0.0151166245,
-0.017189385,
0.03789058,
-0.013928418,
-0.01757225,
-0.0311046,
-0.007782751,
-0.0305237,
0.01538067,
0.00639321,
-0.008508878,
-0.029018639,
-0.011195544,
0.007980785,
-0.029124256,
0.009928124,
-0.042722616,
-0.01002054,
0.03575181,
0.012423357,
0.014139655,
-0.0027559786,
-0.004076208,
-0.03979171,
-0.011202145,
0.00043196251,
-0.033322588,
-0.012852431,
-0.0027972357,
0.009373628,
0.014324487,
0.006951007,
0.00086392503,
0.014324487,
0.017321408,
0.026127337,
0.011083324,
0.0016148054,
0.014601735,
-0.021585748,
0.03715125,
0.019803438,
-0.010211973,
0.023684913,
-0.026576214,
0.024556264,
0.02666863,
-0.0046175015,
-0.021229286,
-0.010911695,
-0.01981664,
-0.030233249,
0.017743882,
-0.0050630793,
-0.0012715458,
-0.050089497,
-0.00028137385,
0.02545402,
0.02125569,
0.019367764,
0.0010726863,
0.030127632,
-0.022127042,
0.0034028909,
0.010271383,
0.0040167975,
-0.008977558,
-0.010060146,
0.0136115635,
-0.011789647,
0.01986945,
-0.005719893,
0.007597919,
0.004620802,
0.001774058,
-0.016661294,
0.006597846,
0.027777623,
0.024793904,
-0.03139505,
0.0028186894,
-0.03276809,
0.0023318548,
-0.014311285,
-0.05840694,
0.0027262734,
0.022853168,
-0.002604152,
0.035566974,
-0.014390498,
-0.0028269407,
0.018628435,
0.0046241027,
0.047000162,
-0.009083177,
0.010674054,
0.020146698,
-0.005340327,
-0.020595577,
-0.01157841,
0.0052050035,
-0.0040465025,
0.030101227,
0.028173693,
0.021361308,
-0.01646326,
-0.0109645035,
-0.008574889,
-0.022470301,
-0.023315249,
0.0068849954,
0.007195249,
0.016885731,
0.009591466,
0.015050613,
-0.0063371,
-0.0026949178,
-0.017004553,
0.0076639308,
-0.0120933,
-0.026497,
-0.025216378,
0.015301457,
0.007974184,
0.0030216747,
-0.009268009,
0.0076573296,
-0.020120293,
0.0149714,
-0.03852429,
-0.0021338204,
0.000036228947,
0.02798886,
0.00020680153,
-0.0007665581,
-0.0016824672,
-0.0029787673,
-0.010924897,
-0.0065384354,
-0.00870031,
0.033903487,
0.0024490252,
-0.017889107,
0.033322588,
-0.008343848,
0.019737426,
-0.014641342,
0.013162686,
-0.029388303,
-0.010740065,
-0.004076208,
0.0062182797,
-0.000071323324,
-0.03598945,
0.013076871,
-0.010733464,
-0.013090073,
-0.029177066,
-0.03115741,
0.0063040946,
-0.02447705,
-0.011215348,
0.004878247,
-0.0080666,
0.04523105,
0.008970957,
0.003927682,
-0.0088587385,
0.014509319,
-0.025163569,
0.025546435,
-0.0046340046,
0.025176771,
-0.012944847,
0.005198403,
-0.0046076,
-0.009941326,
-0.0071094343,
-0.034642816,
-0.034299556,
-0.004891449,
0.0035316132,
0.001071036,
0.0070170183,
0.005719893,
0.005224807,
-0.012172514,
-0.004713218,
0.006617649,
-0.040055756,
-0.003305524,
-0.016450057,
-0.017176183,
0.024041375,
-0.014931792,
-0.02949392,
-0.04816196,
-0.008548484,
-0.0013788145,
-0.010581638,
0.0065384354,
-0.022721145,
0.027170317,
-0.008258034,
0.00955846,
0.011037116,
-0.013261703,
-0.0083174445,
0.029124256,
-0.00599054,
-0.018113544,
-0.010792874,
0.029678753,
-0.0029441111,
-0.007815757,
-0.007465896,
-0.028358525,
0.00029436985,
-0.019790236,
-0.04935017,
-0.008825732,
-0.025757672,
0.022443896,
0.016740507,
-0.026404584,
-0.021361308,
0.00038946763,
-0.0512513,
-0.016714102,
-0.008271236,
0.0024803807,
-0.010621244,
0.0022971989,
-0.008937952,
0.023420867,
0.016516067,
0.0070764287,
-0.03451079,
-0.010647649,
0.015143029,
-0.04850522,
0.010707059,
0.008099606,
-0.025150366,
-0.011109729,
0.021268893,
-0.0023038,
-0.02281356,
0.018073939,
-0.0031371948,
0.015235445,
0.009789499,
0.009941326,
0.006772776,
0.0026916172,
-0.006327199,
-0.010000736,
0.02291918,
0.0034457983,
0.010231776,
-0.0021816788,
-0.007644127,
0.003127293,
0.0016436854,
0.012482767,
0.001797162,
-0.026312169,
0.0040465025,
-0.012925045,
0.01652927,
0.015301457,
-0.02379053,
0.02379053,
-0.0010751617,
-0.005327125,
-0.027566386,
-0.003289021,
0.0045943977,
0.017347813,
0.009155789,
0.009195397,
-0.0061192624,
0.0054459455,
-0.0031718507,
-0.034405176,
0.01998827,
-0.001561171,
0.0029177065,
0.0076969364,
0.0032048565,
-0.004815536,
0.0017410523,
-0.014984602,
-0.010858885,
-0.023249237,
-0.0031635994,
-0.015776739,
0.01336072,
-0.0007632575,
-0.0023120514,
0.009650876,
-0.014548926,
-0.0069708102,
-0.005337027,
0.005049877,
-0.018800065,
0.027751219,
0.17374216,
0.010528828,
0.009954528,
0.017149778,
0.018536018,
-0.006139066,
0.01779669,
0.0014918591,
-0.018087141,
0.00627769,
0.011684028,
-0.007393284,
-0.025652055,
0.00014244036,
0.00506638,
-0.0061258636,
-0.021123668,
-0.009426436,
-0.0076507283,
0.003449099,
-0.016964946,
-0.01399443,
0.0076507283,
0.0012484418,
0.048293985,
0.0036900407,
0.015235445,
-0.017176183,
0.013090073,
0.0020348034,
-0.024556264,
-0.012779819,
0.023183225,
0.009380229,
-0.0022542914,
-0.016106797,
-0.012997657,
-0.0066209496,
-0.008997362,
0.020978443,
0.011070122,
0.0059245285,
-0.024331825,
-0.01204049,
0.0022757452,
0.009624471,
-0.001871425,
-0.018351186,
0.015763538,
-0.006578042,
-0.035434954,
0.0023203029,
0.015763538,
0.024846714,
-0.026048122,
0.0012542178,
0.027328745,
0.0345636,
-0.014654544,
0.021453725,
-0.02925628,
0.0031338942,
-0.005079582,
0.009928124,
-0.012238525,
-0.013902014,
-0.035566974,
0.0026800653,
0.012337542,
0.005337027,
0.0074989023,
0.015024208,
-0.041323174,
-0.009637673,
-0.003076134,
-0.0120470915,
0.013756788,
0.017743882,
0.006812383,
0.011710433,
0.019354561,
0.0016981448,
-0.023605699,
0.017440228,
-0.026457394,
-0.023869745,
0.03559338,
-0.0064196144,
-0.038893953,
0.01295805,
-0.0011279709,
-0.012826027,
-0.019711023,
-0.034114722,
-0.008093005,
-0.0011865561,
0.0098819155,
0.0039144796,
-0.008766322,
0.01462814,
-0.02408098,
0.07160924,
-0.0037263471,
-0.0017311506,
-0.013063668,
-0.0027048197,
-0.009261408,
-0.015631514,
0.007729942,
0.002310401,
0.0025992014,
-0.0339827,
0.017202588,
-0.02452986,
-0.0074526942,
0.027487172,
0.020635182,
-0.025982112,
0.01750624,
-0.010924897,
-0.01399443,
-0.019882653,
-0.011948074,
0.012357346,
-0.007848763,
0.029863585,
-0.012997657,
-0.0004406265,
0.014086846,
-0.030629318,
-0.0023252538,
0.0051686973,
0.0057528988,
0.0028351923,
0.0043798606,
-0.014205666,
0.008746519,
-0.003541515,
-0.031025387,
0.03876193,
-0.009050172,
-0.0024424242,
0.0120470915,
0.010528828,
0.007729942,
-0.013624766,
0.01278642,
-0.00961787,
-0.009868713,
-0.023777328,
-0.01993546,
-0.0043468545,
-0.009941326,
-0.011941473,
0.002067809,
-0.01215271,
-0.0030563306,
-0.018536018,
0.013255102,
0.022787157,
-0.0270647,
0.0053304257,
-0.004878247,
0.0022592423,
-0.0074328906,
0.019605404,
-0.16497585,
0.027328745,
0.0322664,
-0.033243373,
0.017598655,
-0.024173398,
-0.008429663,
0.007690335,
0.016384045,
-0.009736691,
0.02458267,
-0.01802113,
-0.037520915,
-0.04290745,
0.021229286,
-0.0038979768,
-0.0051653967,
0.0052017034,
0.03086696,
0.0016032534,
0.009690482,
-0.019671416,
0.008733316,
-0.02959954,
0.023288844,
0.023896148,
0.0020826617,
-0.005627477,
-0.0130108595,
0.007188648,
-0.012832629,
-0.011142734,
0.024780702,
0.013888812,
0.023988565,
0.0013837653,
-0.008660704,
-0.014733758,
0.004716519,
0.01699135,
0.0016494615,
0.008040196,
0.0023879646,
0.018324781,
-0.021018049,
0.017255396,
0.020093888,
-0.001514963,
-0.004468976,
-0.017347813,
0.026206551,
0.004571294,
0.050379947,
0.02511076,
0.040187776,
0.024345027,
0.015486289,
0.01077307,
-0.012601588,
-0.018205961,
-0.0014984602,
-0.021268893,
-0.005944332,
0.008957756,
0.012357346,
-0.03432596,
-0.0074724974,
-0.02108406,
-0.028965829,
0.018707648,
-0.03881474,
-0.039263617,
0.010522227,
-0.015512694,
0.004977264,
0.04140239,
-0.00091260846,
-0.013321113,
0.015829548,
0.02740796,
-0.033137754,
-0.009175593,
-0.037309676,
-0.0015372419,
-0.01652927,
0.0033071742,
0.02171777,
0.001215436,
-0.00892475,
0.014020834,
0.023486879,
-0.007710139,
0.00305138,
-0.018060736,
0.011829254,
0.017889107,
0.023605699,
0.0120470915,
0.01134737,
-0.011624618,
0.02050316,
-0.001422547,
-0.00000704595,
0.005003669,
0.016252022,
0.014350892,
-0.045125436,
-0.014522522,
0.02413379,
0.019433774,
0.005337027,
0.003201556,
0.0138228005,
0.023275642,
0.010891891,
0.039263617,
-0.021387713,
-0.002856646,
0.024543062,
-0.01278642,
0.06358224,
-0.007050024,
-0.0048386403,
0.008805929,
-0.0030975877,
-0.03490686,
-0.13255101,
-0.035170905,
0.0050597787,
-0.0061885747,
0.008541883,
0.015459884,
0.013902014,
0.018641638,
-0.014680949,
0.0067991805,
-0.008225028,
-0.0096112685,
-0.00014347179,
-0.03144786,
0.016199213,
0.025388008,
0.003046429,
0.018536018,
-0.026879868,
0.019895855,
-0.009030368,
-0.00811941,
0.022008222,
-0.011651023,
0.017836297,
0.0076177227,
-0.016265225,
0.011228549,
-0.0018417197,
0.020912431,
0.017044159,
0.005337027,
0.02701189,
0.017704275,
-0.020489957,
-0.018456805,
0.018588828,
-0.013466339,
0.04393723,
-0.0086409,
0.013446535,
0.014984602,
0.0155523,
0.0097630955,
0.037758555,
-0.010819279,
-0.02586329,
-0.007828959,
0.0063668056,
-0.00944624,
-0.061364256,
-0.029361898,
-0.018628435,
0.006647354,
0.017347813,
-0.0011609766,
0.03311135,
0.013492743,
-0.029784372,
-0.0050828825,
-0.008225028,
-0.007122637,
0.003789058,
-0.004683513,
-0.00053262996,
-0.013519147,
-0.014443308,
-0.03588383,
0.016053988,
-0.01509022,
0.00024300469,
0.011882063,
-0.025071153,
-0.013499344,
-0.036649562,
0.0106344465,
-0.029520325,
-0.01866804,
-0.0052149054,
-0.0032279606,
-0.027830433,
0.0012261629,
0.0058651185,
0.0007310769,
-0.010350597,
0.01596157,
0.0098819155,
0.007399885,
-0.010350597,
-0.02154614,
-0.028543357,
0.0040068957,
-0.0139416205,
0.0025298893,
-0.0069378046,
-0.013076871,
0.0075583123,
0.016423652,
0.027672004,
0.008409861,
-0.007584717,
-0.022430696,
-0.041692838,
0.022800358,
-0.0057561994,
0.010066748,
0.009809303,
-0.010343996,
0.025084356,
0.00083710783,
0.016859327,
-0.008759721,
-0.015288254,
0.0016370843,
0.029335493,
-0.002463878,
-0.0368608,
-0.006904799,
0.04520465,
0.008198624,
-0.00092085986,
0.0066968626,
-0.015816346,
0.004891449,
-0.008944553,
0.0031801022,
-0.027592791,
0.011400179,
-0.023368057,
0.00811941,
-0.015710728,
0.008013791,
0.02125569,
-0.010310991,
0.0054294425,
-0.0056868875,
-0.001871425,
0.010377002,
-0.01757225,
0.03369225,
0.02925628,
0.014047239,
-0.043778803,
-0.03778496,
-0.01060144,
-0.034405176,
-0.0076639308,
-0.0044194674,
-0.06352943,
-0.0032807696,
0.007234856,
-0.0042940457,
0.025427615,
0.01755905,
-0.0024044674,
-0.017809892,
-0.0087069115,
-0.014232071,
-0.005974037,
-0.018126747,
-0.029916395,
-0.010218575,
0.029097851,
-0.006726568,
0.011651023,
-0.009089778,
-0.008026994,
0.0077959537,
-0.014509319,
-0.013083472,
0.031870335,
-0.0035316132,
-0.040161375,
-0.015987976,
-0.001854922,
0.0043270513,
0.014020834,
-0.005337027,
-0.018192759,
0.028437737,
-0.012363947,
6.4141994e-7,
0.026919475,
-0.011618017,
-0.010178967,
0.004079508,
0.035725404,
0.010832481,
-0.017783487,
0.006719967,
0.013743586,
0.010350597,
0.013380523,
0.013222096,
0.0032609662,
0.014311285,
0.011433185,
0.0072546597,
-0.0006646529,
-0.02999561,
0.025071153,
0.041666433,
-0.008277837,
0.014298082,
-0.0022047828,
-0.0038847746,
-0.0059773377,
-0.0006675409,
-0.037072036,
-0.037626535,
-0.0050597787,
0.0002586824,
0.014522522,
-0.008277837,
0.009175593,
-0.011941473,
-0.011063521,
0.0095518585,
-0.012515773,
0.019829843,
-0.0043897624,
0.019605404,
0.00037502762,
0.003996994,
-0.00055820943,
0.00041979164,
0.041508008,
-0.01157181,
0.035963044,
-0.009109582,
0.023104012,
0.002015,
0.011591612,
-0.004366658,
-0.02574447,
-0.0054261424,
-0.002902854,
-0.00811941,
0.008238231,
0.011875462,
0.010284586,
0.06231482,
0.01399443,
-0.012462964,
0.011076723,
-0.010066748,
0.020199507,
-0.02441104,
0.027196722,
-0.013472939,
0.004115815,
0.03247764,
-0.0047198194,
0.040451825,
-0.046551283,
-0.01065425,
0.008951155,
0.0042874445,
0.005620876,
0.017361015,
-0.017519442,
0.023407664,
0.005749598,
-0.0013804646,
0.0035283125,
-0.04348835,
-0.0053832345,
0.05119849,
-0.024661882,
-0.005271015,
-0.033269778,
0.0005148894,
0.0036702373,
-0.029810777,
-0.0049145534,
0.000059461887,
-0.016648091,
-0.0034788041,
-0.0005858517,
0.013849204,
0.03179112,
-0.015011006,
0.020489957,
-0.028437737,
-0.025269188,
0.008898345,
0.00013975865,
-0.003927682,
-0.0008115284,
-0.0351445
] |
Objective:A number of case reports describe multiple family members with gastroesophageal reflux disease and Barrett's esophagus. The wider importance of familial factors in gastroesophageal reflux disease has not been established. Therefore, we have studied the prevalence of reflux symptoms and medication use among relatives of patients with documented gastroesophageal reflux disease. Methods:A postal questionnaire study of the first degree relatives of six groups of matched patients. The groups comprised patients with 1) no dyspeptic symptoms; 2) reflux symptoms and a normal pH study; 3) reflux symptoms, an abnormal pH study, and a lower esophageal sph | [
0.016773133,
0.017712427,
0.016652366,
-0.04312708,
-0.014572497,
0.034378212,
0.010318831,
0.014532242,
-0.0076015834,
-0.006078583,
-0.027320078,
0.0014584239,
0.01400892,
0.009795509,
-0.005682737,
-0.0076485486,
0.040470213,
-0.013499017,
0.01212362,
0.013861316,
-0.008212126,
0.012955568,
-0.0071118083,
-0.024233822,
-0.004662931,
0.02685043,
0.024327751,
-0.038511112,
-0.01527026,
0.0011489596,
0.0039852965,
-0.023415294,
0.0012101815,
-0.011298382,
-0.016652366,
-0.011788158,
-0.016759714,
-0.003924913,
0.021134147,
-0.013532563,
0.012090074,
-0.008950143,
-0.019336067,
-0.0017863386,
-0.012170585,
0.0051325783,
0.022516252,
-0.035773735,
-0.014049176,
0.006125548,
0.018074727,
0.0056793825,
-0.01274758,
-0.0059611714,
-0.0011523142,
-0.0062798606,
0.004478426,
0.0097888,
-0.0050487127,
-0.04167788,
-0.0031399303,
0.016585274,
-0.019698367,
-0.0024622958,
-0.02505235,
0.011653973,
-0.00987602,
-0.0064174007,
0.003817565,
0.016451089,
0.047125794,
0.015914349,
-0.015337353,
0.0030392916,
0.022489415,
-0.004196638,
0.0059779445,
-0.03644466,
0.006357017,
0.010184646,
0.00511916,
-0.008836086,
-0.01095621,
0.011325219,
0.015739907,
0.009527139,
0.009567395,
0.027145637,
-0.019188464,
0.004662931,
-0.00323386,
0.01940316,
0.011365474,
-0.0017796294,
0.0040658074,
0.024569284,
0.01714885,
0.027467681,
-0.010406052,
-0.030379497,
-0.026260016,
-0.0031717992,
-0.01626323,
-0.0052936007,
-0.00925206,
0.0006357017,
-0.014183361,
-0.028366722,
0.00073340524,
-0.026743082,
-0.028608255,
0.04267085,
0.007688804,
0.022033187,
0.023026155,
-0.020771848,
0.019537345,
-0.0130293695,
-0.011560042,
0.001001356,
-0.005649191,
-0.007373469,
0.016558437,
-0.030030616,
0.011123941,
-0.009413082,
-0.03537118,
0.014894541,
0.012432246,
-0.0029352983,
0.0045388094,
0.027185893,
0.015619141,
0.021067055,
-0.035236996,
0.009674743,
-0.0034334601,
-0.0012948858,
-0.018557794,
-0.028635092,
0.013331286,
0.013874735,
-0.01410285,
-0.014706682,
-0.01032554,
0.022060024,
0.043261264,
0.01391499,
0.0014181683,
-0.015216585,
-0.013458761,
-0.023791011,
0.01706834,
-0.011298382,
0.0145456605,
0.006638806,
-0.013680167,
0.011358765,
-0.03402933,
-0.017537987,
-0.020597406,
0.0021033508,
0.019510508,
-0.010801897,
-0.016061952,
0.02254309,
0.017269617,
0.0070581343,
0.0013468825,
-0.007984011,
-0.012968986,
0.015189748,
-0.044334743,
-0.006548231,
0.0024472,
-0.0042872126,
-0.017806357,
0.005045358,
-0.020275362,
-0.008030976,
-0.03322422,
0.01832968,
0.03341208,
0.010674422,
-0.021697724,
0.015699651,
0.024448518,
0.007890081,
-0.015391027,
-0.020449802,
0.0027021517,
0.0048541445,
0.018477283,
-0.014760356,
-0.6359298,
-0.009681452,
-0.006521394,
-0.017551405,
0.0014466826,
0.03107726,
0.012418827,
0.011459404,
0.00440127,
0.015860675,
-0.00718561,
0.022408905,
0.019631274,
-0.013391669,
-0.017390383,
-0.027776306,
-0.019550763,
0.0015749971,
0.02801784,
0.0010181292,
0.00023461418,
0.017390383,
-0.000065834545,
0.015847255,
0.011935761,
0.02981592,
-0.0075009447,
-0.02038271,
-0.012673778,
0.016464507,
-0.0049279463,
-0.009359408,
-0.0006084454,
0.012324898,
0.041999925,
-0.024891328,
-0.011647264,
0.009171549,
0.013250775,
0.021939257,
-0.007534491,
-0.013230647,
0.026904104,
-0.0144919865,
-0.0072258655,
0.018517539,
0.008561007,
0.02470347,
0.013821061,
-0.01922872,
-0.015820418,
0.010627457,
-0.029118158,
-0.0023968806,
0.04645487,
0.003265729,
0.0124590825,
-0.034968626,
-0.02424724,
0.0024136538,
-0.0018517538,
0.012794545,
0.007239284,
0.006142321,
-0.0026518323,
0.0074741077,
-0.008138324,
0.011103814,
-0.0060920017,
0.007568037,
0.0027004743,
0.0074204337,
-0.0018249168,
0.008963562,
0.032123905,
0.024180148,
0.006876984,
0.033734124,
-0.026810175,
-0.005109096,
-0.0020849004,
0.014827449,
-0.015149493,
0.0016781519,
0.033438917,
-0.0014324255,
-0.030245312,
0.008339602,
-0.003030905,
-0.0036364151,
0.005504942,
0.019121371,
-0.015404445,
-0.0032305054,
-0.0028464005,
0.016155882,
-0.039477244,
0.012968986,
0.02046322,
0.0023700437,
0.0012328252,
-0.006430819,
0.0012990792,
0.0032959206,
-0.009446628,
0.008426822,
-0.007742478,
0.00047300232,
0.024770562,
-0.031936046,
-0.0039114943,
-0.0011531529,
0.0026954424,
-0.0023801075,
-0.015471538,
-0.032929014,
0.011734484,
-0.02306641,
-0.012700615,
-0.0004310695,
0.018061308,
-0.016008278,
-0.005649191,
-0.0017167301,
0.0062798606,
0.010023624,
-0.013753968,
-0.01391499,
0.030003779,
-0.008688482,
0.007863244,
-0.007427143,
0.021899002,
0.0015322256,
0.008413403,
-0.004823953,
0.03969194,
-0.011794867,
-0.0027407298,
-0.034727093,
-0.010352377,
-0.0077491873,
0.02424724,
0.001341012,
0.008782412,
-0.00556868,
0.01185525,
-0.025937973,
-0.0113118,
0.0068836934,
0.0045488733,
0.004662931,
-0.012284642,
0.029306017,
0.003014132,
-0.004964847,
-0.0010617393,
-0.02019485,
-0.017095177,
-0.010171227,
0.021952676,
0.0014911315,
-0.032929014,
-0.017537987,
0.002115092,
-0.020261943,
0.006098711,
0.001831626,
0.007568037,
-0.029923268,
0.008728738,
-0.009473465,
-0.012640232,
-0.0020949643,
-0.0047031865,
-0.0035559041,
-0.00552507,
0.02156354,
-0.0059779445,
0.006746154,
0.02326769,
-0.01194918,
-0.0035156487,
-0.00888976,
0.042160947,
-0.004424752,
0.019711785,
-0.0011313477,
0.011023303,
0.026917523,
-0.0069977506,
0.005035294,
-0.01733671,
0.029118158,
-0.016518181,
-0.016035115,
-0.0011019948,
-0.00069734297,
0.0009636165,
0.035263833,
0.021362262,
-0.0050688405,
0.039584592,
-0.018759072,
0.03467342,
-0.016397415,
0.02210028,
-0.0072862487,
0.020168014,
0.028796114,
-0.026555223,
-0.004780343,
-0.0012646941,
-0.008292637,
-0.01490796,
0.025065769,
0.015726488,
0.017189106,
-0.0058102133,
-0.023643408,
-0.016638948,
0.0057699573,
0.033009525,
0.028554581,
-0.01527026,
0.0049514286,
-0.019268975,
0.0060651647,
-0.00049019477,
-0.027534774,
-0.015162911,
0.013807642,
-0.009674743,
0.02191242,
0.009594232,
0.034995463,
0.02307983,
-0.015619141,
0.0059074974,
0.005062131,
-0.0030812244,
0.019416578,
0.0034032685,
0.016142463,
0.0104261795,
0.009379536,
0.022301557,
0.002393526,
-0.027668959,
0.013941827,
0.008158452,
0.005676028,
-0.015820418,
0.006259733,
0.010882408,
-0.010989756,
0.017484313,
-0.010345668,
0.02703829,
0.00870861,
0.028098352,
0.0015431282,
0.00041869932,
-0.032123905,
-0.009996787,
0.02279804,
-0.010875699,
-0.009392954,
-0.013847898,
-0.011627136,
-0.015136074,
-0.0060920017,
0.006833374,
-0.012948859,
0.023321364,
-0.002376753,
-0.00027214407,
0.022744367,
0.01777952,
0.017095177,
-0.02756161,
-0.019523926,
0.010198064,
0.029681735,
-0.003243924,
-0.011747902,
-0.0037840186,
0.005390885,
0.011969307,
0.022637019,
0.019658111,
0.0019725203,
0.009010526,
-0.014263872,
-0.003465329,
0.00052961166,
0.036981404,
-0.00206645,
0.014478568,
0.0061490303,
-0.004273794,
-0.024797399,
-0.026877267,
-0.0002562096,
0.03872581,
0.021348843,
-0.028152026,
-0.0021318651,
0.0013108203,
0.0066522243,
0.013941827,
-0.0023532705,
-0.015686233,
0.0058370503,
-0.008413403,
-0.006655579,
-0.012714034,
0.005317083,
0.020074084,
-0.02210028,
-0.00097368035,
-0.034619745,
-0.022019768,
0.024220403,
0.047635697,
0.015444701,
-0.0019540698,
0.037410796,
0.010801897,
0.014169943,
0.00004775101,
-0.0440127,
0.02469005,
-0.008017558,
0.001277274,
0.013036079,
0.010842153,
0.011526496,
0.015914349,
0.010010205,
0.001201795,
-0.037867025,
-0.004974911,
0.005639127,
-0.019161627,
0.00448849,
0.03188237,
0.001756147,
0.008198707,
-0.035236996,
0.016464507,
0.032660645,
0.0044683623,
-0.009406373,
-0.033116873,
0.0010541914,
-0.018530957,
0.04293922,
-0.014089432,
0.0073868874,
0.017846612,
-0.014585916,
0.00072753464,
0.008004139,
0.023428712,
0.00817858,
-0.005109096,
-0.014169943,
0.004112772,
0.013499017,
0.0022643728,
0.0037873732,
0.001949038,
0.008768993,
-0.0032154096,
-0.020865778,
0.02318718,
-0.026783338,
0.02801784,
-0.0047669243,
0.017564824,
-0.008520751,
-0.0192153,
0.0005707058,
-0.011519787,
-0.020785267,
0.031640835,
0.012928731,
0.009138002,
-0.025360975,
-0.029976942,
-0.038564786,
-0.0029856176,
-0.0125664305,
-0.00052667636,
-0.015162911,
-0.0050319396,
0.009674743,
0.026984615,
0.00960765,
0.013753968,
-0.012049818,
0.009305734,
0.012284642,
-0.009057491,
0.0076082926,
-0.014035758,
-0.025025513,
0.029440202,
0.030057453,
0.0016228006,
-0.009976659,
-0.020812104,
0.025428068,
-0.0071923193,
-0.015230004,
-0.000019996718,
-0.006752863,
-0.009171549,
0.018356517,
0.006216123,
0.0019037505,
-0.042160947,
-0.011170906,
-0.00448849,
-0.007407015,
-0.0076015834,
-0.011633845,
0.0028833013,
-0.0069642044,
-0.016692622,
-0.009916276,
0.00808465,
-0.028608255,
0.036981404,
-0.014894541,
-0.0018500765,
-0.015055563,
0.022221046,
0.028796114,
-0.034888115,
0.047743045,
0.02281146,
-0.021456191,
-0.012989114,
0.021429354,
0.034592908,
0.003646479,
-0.031050423,
0.014143106,
0.017712427,
-0.019698367,
-0.024622958,
-0.019148208,
-0.015672814,
0.03835009,
0.004159737,
-0.01670604,
-0.02541465,
0.010130972,
-0.0062697968,
0.03298269,
-0.016638948,
-0.012338316,
0.0023599798,
-0.008648227,
-0.009050782,
0.004374433,
0.048440807,
-0.034888115,
0.016196137,
-0.0130562065,
-0.01490796,
-0.014263872,
-0.013344704,
-0.001443328,
-0.02702487,
-0.00943321,
-0.007910209,
-0.017376965,
0.008493914,
-0.011895506,
0.019389741,
0.009285606,
0.024864491,
-0.002071482,
0.0063167615,
0.010627457,
0.011063558,
0.012345025,
-0.044764135,
0.0012051496,
-0.022261301,
0.0011053494,
0.016196137,
-0.018477283,
0.019725204,
-0.0042503118,
0.03008429,
0.020879196,
-0.016826807,
0.0047736336,
-0.012009563,
-0.04634752,
-0.0054848143,
0.021241495,
-0.017444057,
0.02927918,
-0.033438917,
0.0017729201,
0.024770562,
0.004310695,
-0.020530313,
-0.011707647,
-0.0039182035,
-0.0371961,
0.035505366,
-0.015377608,
0.017256198,
-0.010640875,
-0.0078095705,
-0.016853644,
-0.01517633,
-0.02254309,
0.006876984,
0.031372465,
0.0017762748,
-0.0015926089,
-0.0030342597,
0.018074727,
-0.0032489558,
-0.00049816206,
-0.015619141,
-0.009285606,
-0.0054915235,
-0.0051225144,
0.022516252,
-0.023858104,
0.01527026,
0.00538753,
-0.0071185175,
0.027615285,
-0.032097068,
-0.0069977506,
-0.021348843,
0.010526818,
0.026072158,
-0.00552507,
0.010661003,
0.010989756,
-0.01168081,
-0.04122165,
-0.010654294,
0.025106024,
-0.0065415218,
0.018168656,
0.02954755,
0.015484956,
-0.0075210724,
-0.0022241173,
0.01607537,
-0.0066522243,
-0.023106666,
0.021254914,
-0.013847898,
-0.0024706824,
0.0012873379,
0.005595517,
-0.010124262,
0.027615285,
-0.004347596,
-0.018611468,
-0.008594553,
-0.015444701,
-0.0124590825,
0.01212362,
-0.039450407,
0.019094534,
0.009366117,
-0.010271866,
-0.028259374,
-0.023831267,
-0.016236393,
0.005773312,
0.0013561078,
0.02083894,
-0.011090395,
0.014612753,
0.00014047498,
0.004689768,
-0.003196959,
-0.010271866,
-0.02989643,
0.042778198,
0.00031072227,
-0.013586237,
0.012291351,
-0.013707004,
0.024059381,
-0.015391027,
-0.019175045,
-0.030621031,
-0.007212447,
-0.0025880942,
0.029252343,
0.012814674,
-0.004505263,
0.0103725055,
-0.014317546,
-0.011197743,
-0.0046293847,
-0.018638305,
0.015565467,
-0.02451561,
-0.022502834,
-0.0070581343,
0.025253627,
0.025763532,
-0.0028698829,
-0.009795509,
0.0014684878,
0.00862139,
-0.03142614,
0.001145605,
-0.0073600505,
-0.008936725,
0.0033529492,
0.032365438,
-0.016786551,
-0.021093892,
0.020168014,
0.003978587,
-0.016947573,
-0.04293922,
-0.002452232,
0.008507333,
0.0016890544,
-0.0131367175,
-0.01139902,
0.0135594,
-0.0027927265,
0.007682095,
-0.00485079,
-0.005407658,
-0.01850412,
0.0098290555,
-0.007507654,
-0.0037068622,
0.018624887,
-0.016383996,
0.005468041,
0.0053472747,
-0.012076655,
-0.0055720345,
-0.027105382,
0.011982726,
-0.025079187,
0.01670604,
-0.02541465,
0.016102208,
-0.009708289,
0.034324538,
0.009379536,
-0.01490796,
-0.009600941,
-0.018356517,
0.009285606,
0.009473465,
-0.000974519,
-0.00610542,
0.003089611,
0.015511793,
-0.016021697,
-0.0048373714,
-0.024743725,
0.039182037,
0.026729664,
0.0077491873,
-0.021402517,
-0.0067931185,
-0.04444209,
0.029144995,
-0.0025511933,
0.0018249168,
0.008467077,
0.00745398,
-0.015001889,
0.021925839,
-0.0192153,
0.026260016,
-0.015833836,
-0.0058504688,
0.02047664,
-0.00091161975,
0.027400589,
-0.013042788,
-0.03172135,
0.0010223225,
0.010385924,
0.0010390956,
0.001030709,
0.020798685,
0.0029202024,
0.034592908,
-0.019711785,
0.0072594117,
-0.0037672454,
0.012365153,
0.02011434,
-0.0041563823,
-0.018839583,
0.007822989,
0.017041503,
-0.025803788,
-0.016115626,
0.022838296,
-0.0037135715,
0.013062916,
-0.026528386,
-0.035156485,
0.011150778,
0.00055057806,
0.020812104,
0.023791011,
-0.025079187,
0.010828734,
0.007621711,
-0.019362904,
-0.017041503,
0.0035860958,
0.008614681,
0.017672172,
-0.0037605362,
-0.02442168,
-0.02596481,
-0.010104135,
-0.004911173,
-0.0014735197,
0.0143846385,
-0.015350771,
-0.0161693,
-0.020087503,
0.010607329,
0.025978228,
0.008399985,
-0.011378893,
0.012472501,
-0.024233822,
-0.009231932,
-0.021657469,
0.014398057,
-0.03521016,
-0.002281146,
0.0098558925,
0.006487848,
-0.001480229,
0.0049715564,
-0.029144995,
-0.030621031,
-0.0016773132,
0.18399455,
0.0023834622,
-0.013156845,
0.009688161,
-0.0091514215,
-0.010587201,
0.002881624,
0.014961634,
-0.017900286,
0.012801254,
0.011231289,
-0.0021821845,
-0.011278254,
0.006484493,
0.016142463,
-0.03099675,
-0.041624207,
-0.026716245,
-0.014894541,
0.0036531882,
-0.007125227,
-0.019819133,
-0.012693906,
-0.0090642,
0.023281109,
0.0117009375,
-0.019698367,
-0.006548231,
0.03818907,
0.005672673,
-0.0085811345,
-0.0055787438,
0.018114982,
0.0199399,
-0.018195493,
0.010278575,
0.003871239,
-0.010265157,
0.010546946,
0.0031785085,
-0.022422323,
0.00056693185,
-0.015350771,
-0.014720101,
0.0051862528,
0.005665964,
-0.009560686,
-0.0036934437,
0.0025830623,
-0.024596121,
-0.02540123,
-0.0039383313,
0.0070648436,
-0.006108775,
-0.007212447,
-0.028581418,
0.024032544,
0.01437122,
-0.023777593,
0.0045656464,
0.024851073,
0.007890081,
-0.011305091,
0.029064484,
-0.021214658,
0.031211445,
-0.010224901,
-0.023106666,
-0.00025788692,
-0.025911136,
-0.011110523,
-0.039182037,
-0.0053305016,
0.010949501,
-0.0015095819,
-0.0042805034,
0.001990971,
0.009258769,
0.014169943,
0.017846612,
-0.014706682,
0.015739907,
-0.039638266,
0.005719638,
-0.030218475,
-0.034109842,
0.005001748,
0.0357469,
-0.02191242,
-0.017283035,
-0.0019104598,
0.020597406,
-0.015297097,
-0.001226116,
0.029064484,
0.0040758713,
-0.006585132,
0.00700446,
0.0084737865,
-0.003646479,
-0.010473144,
0.09591548,
-0.015391027,
0.004320759,
-0.0282057,
0.0071453545,
-0.00020222108,
0.024327751,
0.026300272,
0.019295812,
0.003265729,
-0.01714885,
0.0040557436,
-0.009238642,
0.006078583,
0.005803504,
-0.0020513542,
-0.0069105304,
0.00052332174,
-0.016867062,
-0.015847255,
-0.00046335778,
0.009486884,
0.036874056,
-0.022221046,
-0.0027642122,
-0.010124262,
-0.0053942394,
0.0043677236,
-0.020329036,
-0.009782091,
-0.0371961,
0.014505405,
-0.016598692,
-0.0019289103,
-0.0042536664,
-0.0125127565,
0.007326504,
-0.012385281,
0.027964165,
0.01904086,
0.000060173614,
0.009708289,
-0.005629063,
0.0026602189,
-0.01329103,
0.004652867,
0.02579037,
-0.021845328,
-0.0001921572,
-0.02847407,
0.010432889,
-0.0019775522,
0.0027893719,
0.021697724,
-0.038323253,
-0.020852359,
-0.01553863,
0.021657469,
0.0065448764,
-0.020409547,
0.0037236353,
0.036713034,
-0.022744367,
-0.0032942432,
0.015981441,
-0.16982462,
0.030325823,
-0.0036263512,
-0.0021519929,
0.020422965,
0.003084579,
0.03180186,
0.012029691,
-0.008829377,
0.031640835,
0.03295585,
-0.022744367,
-0.04699161,
-0.016048534,
-0.0023733983,
0.011217871,
-0.028635092,
0.0029923269,
0.030218475,
0.008514042,
0.028581418,
-0.027695796,
0.017430639,
0.010211483,
-0.00642411,
0.0053405655,
-0.012096783,
0.03555904,
-0.004169801,
-0.0022610181,
-0.012828092,
0.010882408,
0.062100846,
-0.020302199,
-0.027266404,
0.00010677147,
-0.0077760243,
-0.02046322,
-0.0007686288,
0.0014701651,
0.023965452,
0.025535416,
-0.0021452836,
0.0064106914,
-0.009654615,
-0.0036162874,
0.04122165,
-0.0045455187,
0.010694549,
0.0028094996,
-0.023522642,
-0.027105382,
0.011553333,
-0.003522358,
-0.025360975,
-0.011056849,
-0.011902215,
0.018383354,
-0.0037940824,
-0.024542447,
0.00096780976,
-0.026380783,
0.038242742,
0.021523284,
0.0065515856,
-0.032204416,
-0.02782998,
-0.017296454,
-0.017135432,
0.022838296,
-0.020664498,
0.0032204415,
-0.0018249168,
-0.013425215,
0.018356517,
0.016316904,
-0.022516252,
0.025978228,
-0.004552228,
-0.011432567,
-0.008587844,
-0.010151099,
-0.024381425,
-0.019631274,
0.015739907,
0.016786551,
-0.01159359,
0.010271866,
0.0005816084,
-0.0036766706,
0.042617176,
-0.03644466,
0.008044395,
-0.009460047,
0.015162911,
0.0000045012275,
-0.010761642,
0.01481403,
0.0009686484,
-0.015592304,
0.018168656,
-0.035934757,
-0.030003779,
0.0006600228,
0.05603568,
-0.021214658,
-0.007152064,
0.0018299487,
0.030030616,
-0.038645297,
0.0004088451,
-0.004381142,
0.010902536,
0.014143106,
-0.00970158,
0.026917523,
0.0112111615,
-0.00569951,
-0.0043677236,
-0.0028464005,
0.04508618,
0.0002866109,
0.014424894,
-0.013351413,
0.015525212,
-0.013639911,
-0.104610674,
-0.015068982,
0.015377608,
0.0060182,
-0.012707325,
-0.00042771487,
-0.007970593,
0.006216123,
-0.012150457,
0.016196137,
-0.021335425,
-0.012546303,
0.0023465613,
-0.02801784,
0.026555223,
-0.0072057378,
0.008285928,
-0.029762246,
-0.045461897,
0.020865778,
-0.0017175687,
0.008433531,
0.014867704,
0.006923949,
0.011660682,
-0.03333157,
-0.010882408,
-0.017470894,
0.021952676,
0.010412761,
-0.001746083,
-0.0015775131,
0.0020312264,
-0.02839356,
-0.021120729,
-0.017229361,
0.0054479134,
-0.010634166,
0.042268295,
-0.020329036,
0.016907318,
0.017175687,
0.012828092,
0.0105134,
-0.0054747504,
-0.021979513,
-0.043261264,
0.009889439,
0.009392954,
0.0035055846,
-0.003265729,
-0.025683021,
-0.039182037,
-0.0020211625,
0.02981592,
-0.018289423,
-0.0039383313,
0.02495842,
-0.016182719,
-0.0025092606,
-0.01517633,
-0.0020731592,
-0.007977302,
0.015203167,
0.014787193,
0.0070312973,
0.030460007,
-0.038591623,
0.007715641,
-0.033116873,
-0.022288138,
0.010627457,
-0.015659396,
0.014263872,
-0.028178863,
0.034807604,
-0.017054921,
-0.0074137244,
0.014277291,
-0.019886225,
0.0032741155,
-0.011519787,
0.019107953,
-0.014143106,
0.031130934,
-0.007346632,
0.015162911,
0.0060148453,
-0.0065951957,
-0.036874056,
-0.013901572,
0.0522785,
0.0028480778,
-0.005504942,
-0.019832551,
0.006313407,
-0.0065079755,
-0.027588448,
0.014263872,
-0.009030654,
-0.01239199,
-0.028232537,
-0.050426744,
0.01599486,
0.00070782617,
-0.0086079715,
-0.012331607,
-0.0038846575,
0.036793545,
-0.008574425,
0.013465471,
0.0045857746,
-0.0061758673,
0.025065769,
0.00072418,
-0.023858104,
-0.020436384,
-0.0078028613,
0.027051708,
0.012197422,
0.023965452,
0.034351375,
-0.00167312,
0.018114982,
-0.0024622958,
0.021348843,
-0.02866193,
0.015458119,
-0.014746938,
0.035532203,
-0.029225506,
-0.02046322,
0.00075017835,
-0.021187821,
-0.008862923,
-0.001965811,
-0.01230477,
0.0016739586,
-0.00050403265,
0.017256198,
0.048118763,
0.035156485,
-0.013733841,
-0.030406334,
0.013176973,
-0.0073399227,
0.015015308,
0.018383354,
-0.027051708,
0.024488773,
0.013767387,
-0.020074084,
0.022127116,
0.0057766666,
-0.006212768,
-0.026031902,
-0.00789679,
-0.0061456757,
0.016545018,
0.011016593,
-0.015122656,
-0.016182719,
0.025092606,
0.004830662,
0.01391499,
0.019698367,
-0.0052701184,
-0.0051057413,
-0.020100921,
-0.014720101,
0.013284321,
-0.0371961,
0.00039982953,
-0.005944398,
0.0059074974,
0.024649795,
0.005169479,
-0.0020463222,
-0.009030654,
0.019175045,
0.0105134,
0.013223938,
-0.0013460439,
-0.011103814,
-0.034270864,
0.030701542,
0.03107726,
0.026340527,
-0.011352056,
-0.015310516,
-0.013150136,
0.021872165,
-0.018007634,
0.027440844,
-0.011258126,
0.046562217,
0.016786551,
0.016397415,
0.004069162,
-0.01850412,
0.028527744,
0.02317376,
-0.0034083005,
0.027695796,
-0.028688766,
-0.028232537,
0.0016001568,
-0.012264514,
-0.04363698,
-0.031855535,
-0.030594194,
0.012519466,
0.019201882,
0.00960765,
-0.006984332,
0.0061456757,
0.0028849787,
-0.015726488,
-0.011392311,
-0.019711785,
0.017712427,
0.023482386,
0.0051325783,
0.036203127,
0.007346632,
0.019456834,
0.02487791,
-0.020825522,
0.034727093,
-0.005602226,
0.029923268,
-0.017108595,
0.0049245916,
0.0014475213,
-0.011969307,
-0.022771204,
-0.0034301055,
-0.025709858,
-0.0033244349,
0.000060173614,
0.0034083005,
0.06575068,
-0.0072728302,
-0.0063603716,
0.026743082,
-0.006336889,
0.008332892,
0.012432246,
0.008393276,
-0.011217871,
-0.028688766,
-0.004193283,
-0.016491344,
0.0267565,
0.002249277,
-0.011539915,
0.001438296,
0.025481742,
-0.012163876,
-0.008594553,
-0.016746296,
0.0017108595,
-0.008077941,
0.012016272,
-0.00043819807,
-0.0043073404,
-0.010204773,
0.024381425,
0.00089987856,
-0.012385281,
-0.01930923,
-0.008292637,
0.028259374,
-0.044227395,
-0.005468041,
0.02397887,
-0.023482386,
-0.011231289,
-0.010848862,
0.022932226,
0.0042536664,
0.004887691,
0.008561007,
-0.007158773,
0.005991363,
-0.010218192,
-0.015297097,
-0.021764817,
-0.018906675,
-0.018893257
] |
Some three decades have passed since the discovery of nucleosomes in 1974 and the first isolation of a histone chaperone in 1978. While various types of histone chaperones have been isolated and functionally analyzed, the elementary processes of nucleosome assembly and disassembly have been less well characterized. Recently, the tertiary structure of a hetero-trimeric complex composed of the histone chaperone CIA/ASF1 and the histone H3-H4 dimer was determined, and this complex was proposed to be an intermediate in nucleosome assembly and disassembly reactions. In addition, CIA alone was biochem | [
-0.012112537,
0.022238074,
0.00917967,
-0.039086748,
-0.013623202,
0.0280902,
-0.0075873476,
-0.012772603,
-0.010527019,
-0.0007272626,
-0.003067262,
0.008458362,
0.0032203698,
0.00367459,
0.004297229,
0.004579628,
0.01352113,
-0.015637422,
-0.0059610014,
0.00007230096,
-0.03503109,
-0.0028171856,
-0.018808456,
-0.012820236,
-0.0069613066,
-0.003085975,
0.0187268,
-0.047334164,
-0.0007600107,
-0.020264683,
0.008458362,
-0.0016501631,
0.004657883,
-0.0111734755,
-0.012616092,
-0.0046544806,
0.005651383,
-0.0219931,
0.012983551,
0.005464251,
0.026007932,
0.011445668,
-0.012724969,
0.021639252,
-0.02670202,
0.012949527,
0.0009152451,
-0.014902504,
-0.020142198,
0.02138067,
0.007716639,
0.019938054,
-0.009465472,
0.007594153,
-0.018835677,
-0.020645753,
0.0101255365,
0.013752493,
0.0043822885,
-0.029968323,
-0.012806627,
-0.025899054,
-0.009928198,
0.02769552,
0.01118028,
0.015297182,
0.029233405,
-0.010152756,
0.004419715,
0.00787315,
0.03369735,
0.010499801,
-0.027232794,
-0.010377314,
0.03571157,
-0.027831616,
-0.019461717,
-0.0003576771,
-0.01203088,
-0.003349661,
0.009513105,
-0.012650116,
0.0021128892,
0.0022455829,
0.009104817,
0.016821457,
0.02535467,
0.009084403,
0.013133257,
0.010547434,
0.034296174,
0.037943542,
0.016971162,
0.020169416,
-0.02471502,
0.0147119695,
0.003555506,
0.01770608,
-0.003332649,
-0.02833517,
-0.029206185,
-0.0017539362,
-0.029233405,
-0.019189525,
-0.028199075,
-0.005794284,
0.015433278,
-0.021054039,
-0.011119037,
0.000983293,
0.0027695522,
0.024225075,
0.0076213717,
-0.035521038,
0.01973391,
-0.030458268,
0.008750968,
0.006239998,
0.025953492,
-0.026892554,
-0.0038855386,
0.04877678,
0.022564704,
-0.033125747,
0.012139756,
-0.00042147207,
-0.018754018,
-0.016195415,
0.0029856043,
-0.014290072,
0.003752845,
0.019788347,
0.027287234,
0.0063556796,
-0.033642914,
0.01303799,
-0.012949527,
-0.011200694,
-0.0022353756,
-0.042516366,
0.026198465,
0.034840558,
-0.02606237,
-0.01667175,
0.0152155245,
0.028362392,
0.011636201,
0.010894479,
-0.0053962036,
0.021639252,
0.021299012,
0.002368069,
0.009492691,
0.028144637,
0.0131604755,
0.0407199,
-0.007526105,
0.00500833,
-0.012432363,
-0.023354061,
-0.01051341,
-0.009737663,
0.008710139,
-0.008056879,
0.007737053,
0.024959993,
-0.0040862802,
-0.011867564,
0.0005073826,
-0.018930944,
0.0018883309,
-0.0075533236,
-0.0045932373,
-0.0015668044,
-0.022551095,
0.0012495307,
0.02339489,
0.032200295,
-0.03938616,
-0.02300021,
0.005511885,
-0.00039871852,
0.02470141,
-0.0039025506,
-0.019488936,
0.0007748962,
-0.0020159208,
-0.011608982,
0.019951662,
-0.013153671,
-0.010758383,
-0.01435812,
-0.008580848,
-0.009016355,
-0.62538797,
-0.011636201,
0.008730554,
-0.03473168,
0.0058487225,
0.012582068,
0.005981416,
0.024946382,
0.00032641756,
0.012398339,
-0.0032799118,
0.021584814,
0.012847455,
-0.021938663,
-0.05743248,
-0.032581363,
-0.008553629,
-0.011942417,
0.039903324,
-0.007784687,
-0.022346951,
0.0007000434,
-0.026144028,
-0.008070488,
0.016181806,
-0.019992491,
0.03641927,
-0.020672971,
-0.01268414,
0.011234718,
0.0032322782,
0.015936833,
-0.018617922,
0.016590092,
0.041209847,
-0.0027015042,
0.0035078723,
0.0073627895,
0.026198465,
0.03010442,
-0.0057806745,
-0.023939272,
0.015269963,
0.021761738,
-0.0059405873,
0.024470048,
-0.00064475444,
0.0065428116,
-0.00086293323,
-0.015596593,
0.0026368585,
-0.0013915808,
0.00070174463,
0.01369125,
-0.016753409,
0.012793017,
0.02501443,
-0.016617313,
0.016889505,
0.012105732,
-0.012561654,
0.005144426,
-0.029233405,
-0.016018491,
-0.031628694,
0.021802567,
-0.009390619,
-0.0032373818,
0.018862896,
0.008907478,
0.012228219,
0.03576601,
-0.0061651454,
-0.0069000633,
-0.005562921,
0.018495437,
-0.0025330854,
0.0102956565,
-0.010976137,
0.024510875,
-0.009785297,
0.006291034,
-0.0035759204,
-0.013003966,
0.0125548495,
-0.009002745,
-0.018767629,
0.03102987,
-0.012405143,
-0.008505995,
0.0012597379,
0.015501326,
0.020577705,
-0.009057184,
-0.033534035,
0.021734519,
0.009288547,
-0.016984772,
0.010486191,
-0.024075368,
0.0050389515,
-0.0064067156,
-0.004368679,
-0.020931553,
0.00082933455,
0.009635592,
-0.018481826,
0.0005443837,
0.05607152,
-0.0048314054,
0.010561043,
-0.008907478,
-0.027613863,
-0.0081385365,
0.0029260623,
-0.017883005,
0.018209634,
0.018754018,
0.0010326279,
-0.010207194,
0.015555765,
0.019216744,
-0.002281308,
-0.0029958116,
0.034867775,
0.026497876,
0.0038515148,
-0.03165591,
-0.033887886,
0.0014842962,
0.009125232,
0.020155806,
0.016494825,
-0.025980713,
0.017964663,
0.028444048,
0.022632752,
-0.0117791025,
0.008213389,
-0.040175516,
-0.024619753,
-0.0071586454,
-0.002827393,
0.018645141,
-0.014208415,
-0.024238683,
-0.026974212,
0.00717906,
0.009832931,
-0.0021469132,
0.008546824,
0.015896004,
-0.0026283525,
0.0055254945,
0.0035487013,
-0.008165755,
0.002580719,
-0.046871435,
-0.011200694,
-0.014739188,
-0.0019427693,
0.0109012835,
-0.01335101,
0.020877115,
-0.01935284,
-0.018849285,
0.023626253,
-0.013779712,
-0.0038549171,
-0.029587254,
0.014888894,
0.00049504894,
-0.04306075,
0.013541545,
-0.007213084,
0.016494825,
0.013977052,
0.013344205,
-0.009472276,
0.0049334774,
-0.025803788,
0.0032084615,
-0.0075669335,
-0.014235633,
0.031846445,
0.015896004,
0.03878734,
0.014290072,
0.024551705,
0.038215734,
0.018318512,
-0.0022200649,
0.015229134,
0.008798601,
0.003922965,
-0.017624423,
0.01739306,
0.0076622004,
-0.015909614,
0.01369125,
0.028552925,
0.0053315577,
-0.001427306,
-0.03780745,
0.0083426805,
-0.0070633786,
-0.0021418096,
-0.004579628,
0.0018185818,
0.0009356595,
0.003769857,
-0.035194404,
-0.0011261938,
-0.009635592,
-0.01737945,
0.022632752,
-0.0340512,
0.0044843606,
-0.031165967,
-0.012132952,
0.010037075,
0.008846235,
0.02742333,
-0.0021026821,
-0.008866649,
-0.0055765305,
-0.0046953093,
0.009118427,
-0.00005486367,
-0.005498275,
-0.006889856,
0.019502547,
-0.012595678,
0.016181806,
0.021149307,
0.032962434,
-0.00008878133,
-0.0044571417,
0.03073046,
-0.0066550905,
-0.014535044,
-0.0029702936,
-0.003742638,
-0.014766408,
0.021448718,
-0.0136640305,
0.022796066,
-0.010234414,
-0.011323181,
0.020890724,
-0.010091512,
-0.0066618957,
-0.0021724312,
0.009091208,
0.009635592,
-0.006750358,
0.009574348,
0.028961213,
0.032118637,
0.02410259,
0.015460497,
-0.013561958,
0.0025875238,
-0.029287843,
-0.0030026163,
0.0005252452,
-0.009098013,
0.01834573,
-0.027355282,
-0.029369501,
-0.01736584,
0.0032441865,
0.012180585,
-0.014494216,
0.028797898,
0.008097707,
0.00040956368,
0.016522046,
0.00783232,
-0.01269775,
-0.027464157,
-0.042924654,
0.017066428,
0.0027015042,
-0.003987611,
-0.0019955065,
-0.0094858855,
0.014861675,
-0.013977052,
0.0010785602,
-0.01667175,
-0.0070837927,
-0.009792102,
-0.0039774035,
-0.020523265,
0.00083869114,
0.02505526,
-0.01837295,
0.012330291,
-0.0075329095,
0.010527019,
-0.018332122,
-0.015623813,
-0.007437642,
0.03611986,
0.011146256,
-0.006522397,
-0.00077999977,
-0.0019989088,
-0.012963137,
0.010833235,
0.004817796,
-0.004331253,
0.0066346764,
-0.017991882,
-0.016916724,
-0.022224465,
0.016467607,
0.028961213,
0.004889246,
0.004770162,
-0.008322266,
0.003545299,
0.0047803693,
0.03680034,
0.025967102,
-0.029995542,
0.02602154,
0.014194805,
0.0032084615,
0.0066687004,
-0.0256813,
0.036881994,
-0.0077030296,
-0.009615177,
0.0069272825,
0.0010377314,
0.02172091,
0.019747518,
0.026974212,
0.009370204,
-0.039086748,
0.0005375789,
-0.00004819178,
0.014766408,
-0.014031489,
-0.0069272825,
0.044612244,
0.016794236,
-0.0154196685,
-0.00038787338,
0.035493817,
-0.009635592,
-0.01352113,
0.023639861,
-0.002478647,
0.0082746325,
0.011663421,
-0.02573574,
-0.024660582,
0.008451557,
0.020223854,
0.013446277,
-0.012935918,
-0.009247718,
-0.0019308609,
0.013881784,
-0.0075873476,
-0.0016297487,
-0.014562264,
0.018631533,
0.020183025,
-0.031819228,
0.009894174,
0.03309853,
-0.009730859,
0.016549265,
-0.0053859963,
-0.0026062368,
-0.027164746,
-0.008233803,
-0.011044185,
0.00029558333,
-0.0015846669,
-0.023775958,
-0.019271184,
-0.00032407843,
-0.0023204356,
0.014235633,
-0.03369735,
-0.012289462,
-0.021897834,
-0.011922003,
-0.011840345,
0.013684445,
-0.021530375,
-0.028607363,
-0.00022923657,
0.020414388,
0.022877725,
0.019216744,
-0.011629397,
-0.006930685,
0.0021843396,
-0.0056990166,
-0.0059916233,
-0.00476676,
-0.028580144,
0.0037970764,
0.00041402932,
0.016807847,
-0.02309548,
-0.009213694,
0.0055527138,
-0.003067262,
0.0043210457,
0.024905555,
-0.0015225732,
-0.015201915,
0.029859446,
0.021557594,
0.040284395,
-0.0021928456,
-0.014848066,
-0.010268438,
-0.009669616,
-0.010336486,
-0.0131945,
0.002187742,
0.0014723878,
-0.014807236,
0.0067571625,
-0.012738579,
-0.011479692,
0.03377901,
-0.0054200203,
-0.0020754628,
-0.00818617,
0.0019938054,
0.009043574,
-0.008975526,
0.01252763,
-0.005641176,
-0.01701199,
-0.018468216,
-0.008900673,
0.032173075,
0.0041373163,
-0.022238074,
0.030213295,
-0.0032646009,
-0.010622287,
0.000018394216,
-0.0053996057,
-0.032036982,
0.039168406,
-0.017420279,
-0.03301687,
-0.016399559,
-0.017107258,
-0.007900368,
-0.0025960298,
0.0022200649,
-0.020618532,
-0.0052601076,
-0.0054540443,
-0.016168196,
0.0072198887,
-0.021448718,
-0.030077199,
-0.005239693,
0.018890115,
0.0012997161,
0.020509657,
-0.015147476,
-0.0037460404,
-0.013323791,
-0.011697445,
-0.0013090727,
-0.027504986,
0.023612643,
0.004266607,
0.022918554,
0.02572213,
0.043795668,
-0.011146256,
-0.0016867389,
0.02106765,
0.014725579,
-0.0076690055,
-0.0062842295,
0.02540911,
0.0003157851,
0.025341062,
0.026144028,
-0.0052090716,
0.00668231,
-0.020550484,
0.030294953,
0.019298403,
0.01505221,
-0.066741444,
0.02172091,
-0.04308797,
-0.022210855,
-0.00063284603,
-0.011595373,
-0.018454608,
-0.023599034,
0.008444753,
-0.002888636,
-0.0065292018,
0.022741629,
-0.013473497,
0.053349603,
0.008179365,
0.027477767,
-0.013405449,
-0.00984654,
-0.013493911,
-0.014739188,
-0.010785602,
0.010908089,
0.034187295,
-0.00499472,
0.015324401,
0.019488936,
-0.043795668,
0.004477556,
0.021843396,
-0.0043993006,
0.0048075886,
-0.019584203,
-0.019924443,
-0.0076281764,
-0.04047493,
-0.0018304902,
-0.04507497,
0.0038549171,
-0.015474106,
0.00045124305,
0.004991318,
-0.0036099444,
0.0032407842,
0.0353305,
-0.0068558324,
0.03331628,
-0.008553629,
0.023027431,
0.0057160286,
-0.0074988855,
-0.018549874,
-0.023653472,
-0.0029277636,
0.014725579,
0.034296174,
0.030648801,
-0.016277073,
-0.010404534,
-0.01085365,
0.010758383,
-0.010241218,
-0.056724783,
-0.0049198675,
0.010676725,
0.008485581,
-0.006624469,
0.00733557,
-0.00063624844,
0.017529154,
0.011819931,
0.0027372292,
-0.004127109,
-0.017148087,
0.00018128402,
0.006539409,
-0.0070974026,
0.020087758,
0.009615177,
0.0102276085,
0.011853955,
-0.024946382,
0.020523265,
-0.010268438,
-0.01766525,
0.03410564,
-0.023966493,
0.0034194102,
-0.008451557,
0.027872445,
-0.017569983,
-0.004317643,
-0.008070488,
0.034459487,
-0.0016722786,
0.0031336087,
0.013595982,
0.019951662,
0.00025220276,
-0.0015872187,
-0.00059414376,
-0.012622897,
-0.018903725,
0.0019376657,
0.016508436,
0.009240913,
-0.011493301,
-0.029315062,
-0.004702114,
0.019135088,
-0.03971279,
-0.009601568,
-0.0032594975,
-0.023354061,
-0.027096698,
0.0038242955,
0.021258183,
0.02400732,
-0.0056105545,
-0.013112842,
-0.019420888,
0.02174813,
-0.0066687004,
0.00934979,
0.017202524,
0.003718821,
-0.03230917,
-0.016290681,
-0.016018491,
-0.029587254,
0.010492995,
-0.015678251,
-0.020958772,
-0.00041275343,
0.0036439684,
0.036609802,
0.023503765,
-0.011901588,
-0.007492081,
0.011112233,
0.025654081,
0.019271184,
-0.021802567,
0.0066278717,
-0.023027431,
-0.004896051,
-0.0007748962,
-0.027178356,
-0.011343596,
0.0009458667,
-0.0056615905,
0.010302462,
-0.01565103,
0.009063989,
-0.013602788,
-0.023871224,
-0.019870006,
-0.006049464,
0.008261023,
-0.01973391,
-0.0071042073,
-0.0037630524,
-0.013473497,
-0.023884835,
-0.015610202,
-0.0010028569,
0.02470141,
-0.009220499,
-0.014589483,
-0.015269963,
0.018577093,
-0.03410564,
-0.04845015,
-0.00080509245,
0.002368069,
0.02434756,
-0.0017156593,
-0.019815566,
-0.0015370334,
-0.006518995,
-0.021271793,
-0.0011006758,
0.0031046884,
0.0062672175,
0.008335875,
0.013323791,
-0.011806321,
-0.003026433,
-0.024538096,
0.0073219608,
0.0035316893,
-0.024129808,
0.017161695,
-0.007546519,
0.027545815,
0.01235751,
-0.01669897,
0.016726188,
0.028199075,
-0.0036269564,
-0.03233639,
0.013595982,
0.020591313,
0.016943943,
-0.0037596498,
0.017951053,
-0.0015668044,
0.024932774,
0.02102682,
-0.018536264,
-0.0046102493,
-0.023530986,
0.0005209922,
-0.025041651,
-0.002374874,
-0.017624423,
0.008621677,
-0.017733298,
0.0016229439,
-0.029178966,
0.0034415256,
-0.029287843,
0.018971771,
0.015678251,
0.0030230307,
0.017842175,
0.015256353,
-0.008567238,
-0.00026666294,
-0.0117110545,
-0.025667692,
-0.0029430743,
0.0055391043,
-0.017569983,
0.017216135,
-0.006083488,
0.013738884,
-0.02841683,
-0.0012070007,
-0.008574043,
-0.0033615693,
-0.02334045,
0.037589695,
-0.011214304,
0.0029856043,
-0.003528287,
-0.006488373,
-0.015637422,
0.011187085,
0.0063794963,
-0.021162916,
-0.03677312,
0.004307436,
0.0014672842,
-0.02536828,
-0.005083183,
-0.00050355494,
0.0016093343,
-0.019992491,
0.01600488,
0.18879227,
-0.015909614,
-0.004127109,
-0.005664993,
-0.025790177,
-0.023694301,
0.023571813,
-0.008022855,
0.008533214,
0.0035350916,
0.017161695,
0.007056574,
-0.02434756,
-0.0008982331,
0.009758078,
-0.014984162,
-0.012350705,
-0.018549874,
-0.042598024,
0.009642396,
0.020332731,
-0.013813736,
0.024293123,
-0.0032901189,
0.02098599,
-0.024088979,
0.0006957904,
-0.011704249,
-0.023789568,
0.024265904,
-0.027151138,
-0.01353474,
-0.016753409,
0.0052669123,
0.0026640778,
0.005790882,
-0.01637234,
0.006222986,
-0.017855786,
0.014752798,
-0.028062979,
-0.0078119063,
0.0016544161,
0.00013120497,
-0.0130584035,
-0.0013507521,
0.009145646,
-0.02501443,
-0.015800737,
0.010084708,
-0.046599243,
0.0074648615,
-0.00017894487,
0.023476547,
-0.011214304,
-0.0065292018,
0.0016960955,
0.009996246,
-0.0009977532,
0.021190135,
-0.019257573,
0.020114977,
-0.03870568,
-0.0014094434,
0.009036769,
0.023109088,
0.0038957458,
0.010812821,
0.032608584,
-0.03538494,
0.0046782973,
0.012425558,
-0.03573879,
-0.0144397775,
0.0038242955,
-0.0041339137,
0.059065633,
0.020836286,
0.005137621,
0.009050379,
-0.007954807,
0.0002809105,
-0.023639861,
0.012643311,
0.012126147,
-0.0314926,
0.025286622,
0.008608067,
-0.0280902,
-0.028117418,
0.0125548495,
-0.008084098,
-0.0068388204,
-0.007750663,
0.024116198,
-0.00094756787,
0.020523265,
0.02803576,
-0.0068830512,
0.007444447,
-0.026797287,
0.043795668,
0.013405449,
0.020251073,
-0.014004271,
0.0016357029,
0.01252763,
-0.0102616325,
0.0103637045,
-0.025980713,
0.010914893,
-0.0111054275,
0.0069681113,
-0.01871319,
0.014793627,
0.02040078,
-0.02300021,
-0.039631132,
0.03734472,
-0.027613863,
-0.012643311,
-0.016753409,
0.0038719291,
0.02309548,
-0.029178966,
-0.008056879,
-0.021897834,
0.0014366626,
0.0029430743,
-0.028171856,
0.0070361593,
0.0007021699,
0.008859845,
0.027504986,
0.004297229,
-0.031547036,
0.008444753,
0.012479996,
-0.008029659,
0.017760519,
-0.011901588,
-0.021462327,
0.026878946,
0.0064815683,
-0.020632142,
0.0045319945,
0.0157463,
0.010248023,
-0.040855996,
-0.010846845,
0.0033173382,
-0.003084274,
0.0072539127,
0.007859539,
0.0118811745,
-0.028852336,
-0.0207138,
-0.031900886,
-0.021054039,
0.0136980545,
-0.0144397775,
0.017080039,
0.021897834,
0.006246803,
-0.01152052,
0.00024199557,
-0.17213413,
0.023408499,
0.011091818,
-0.0130924275,
0.025858225,
0.0075873476,
0.025749348,
-0.0039093555,
-0.012282657,
-0.02237417,
-0.0064747636,
0.0076213717,
-0.024796678,
-0.06211418,
-0.0030196283,
0.021625642,
-0.0073559848,
0.026552316,
0.032227516,
-0.0036099444,
0.024769459,
-0.03111153,
0.04036605,
-0.008247413,
0.019475326,
0.030458268,
0.00559014,
-0.009826126,
-0.012595678,
-0.014181196,
-0.0074648615,
-0.0067537604,
0.0069681113,
-0.013909004,
0.035874885,
-0.0039774035,
0.0066618957,
-0.00079233345,
0.00062434,
0.014616703,
0.019625032,
0.008825821,
0.001132148,
-0.017569983,
-0.005777272,
0.005964404,
-0.0058487225,
-0.0022540886,
0.035602693,
-0.0071178167,
-0.016467607,
-0.0039978176,
0.020291902,
0.01018678,
0.004263205,
0.0015013082,
0.009914588,
0.039685573,
-0.010003051,
-0.006621067,
-0.0053655817,
0.0076349815,
0.05043715,
-0.009268132,
-0.029995542,
-0.028634582,
-0.0011593672,
0.013051599,
-0.026960602,
-0.000095479794,
0.01435812,
-0.0154877165,
-0.0059780134,
-0.026511487,
0.029587254,
0.023789568,
0.0023799774,
0.0033683742,
-0.0012393235,
0.013561958,
-0.0077234437,
0.033561256,
-0.021217356,
-0.039495036,
-0.0039093555,
0.00032216456,
-0.012929113,
0.0016263463,
-0.006587043,
0.010765187,
0.019298403,
-0.024919163,
0.006906868,
-0.010887674,
0.038950652,
0.031084308,
-0.010819626,
-0.026484268,
0.006604055,
-0.019298403,
0.0033020275,
-0.012724969,
-0.01401788,
0.034813337,
0.027845226,
0.03478612,
-0.025436329,
0.0076349815,
0.036473706,
-0.023952883,
0.01218739,
-0.0009781894,
0.03141094,
0.03274468,
0.00350447,
0.028307952,
-0.004436727,
-0.00081870204,
-0.012745383,
-0.028743459,
0.06048103,
0.013133257,
-0.04281578,
-0.010894479,
-0.005770467,
-0.023503765,
-0.12836568,
0.0018049722,
-0.021394279,
0.007716639,
0.0089142835,
0.022401389,
0.006274022,
0.03467724,
-0.017066428,
0.029070089,
-0.013282962,
0.00919328,
0.01335101,
-0.0002456106,
0.009948612,
-0.0013533039,
0.0023000212,
-0.037235845,
-0.010676725,
0.025191355,
0.003752845,
-0.003487458,
0.018127978,
-0.03073046,
0.01973391,
-0.021543985,
-0.004290424,
0.024769459,
0.025300233,
0.011942417,
-0.012241828,
-0.011030574,
-0.007934392,
0.00021817879,
-0.013078818,
-0.0077438583,
-0.0073219608,
-0.022986602,
0.03606542,
-0.03111153,
-0.00048271523,
-0.0010351796,
0.0071518407,
0.0008880259,
0.015827956,
-0.01401788,
-0.007485276,
-0.0032628998,
0.014780018,
0.011799517,
-0.019597813,
-0.008465166,
-0.023217965,
-0.031356502,
0.028879555,
-0.0040862802,
0.0071586454,
0.024442827,
-0.011962832,
-0.020781849,
0.018440997,
0.008369899,
-0.007376399,
-0.005596945,
0.017461108,
-0.0051750476,
0.0009952014,
-0.0048824414,
0.01336462,
-0.0101935845,
0.0033649718,
0.02572213,
-0.03209142,
0.0074648615,
-0.009322571,
-0.00081487437,
-0.033261843,
-0.0140451,
0.006573433,
-0.015460497,
-0.010118732,
-0.027164746,
0.0077914917,
-0.015623813,
0.02640261,
0.00022923657,
0.022932163,
0.0131945,
0.019529765,
0.0015064118,
0.0037154187,
0.039984982,
-0.006117512,
-0.009308961,
-0.015310791,
0.011438862,
-0.027954103,
-0.0036984067,
0.01037051,
0.022306122,
-0.02841683,
-0.014085928,
-0.06581599,
0.008594458,
0.0061413287,
-0.018822066,
0.033207405,
-0.010390924,
0.001435812,
-0.004538799,
-0.003691602,
0.017964663,
-0.038515147,
0.008900673,
-0.0160321,
-0.0074308375,
-0.022591924,
0.0046442733,
0.032472488,
-0.006348875,
0.008444753,
0.02338128,
-0.01252763,
0.0025092687,
0.021775348,
0.018318512,
-0.003111493,
-0.00022094323,
-0.0032611985,
0.023190746,
0.000713653,
0.0050185374,
0.014902504,
-0.02135345,
-0.022020321,
-0.00046527793,
-0.0077642724,
-0.019284792,
-0.0280902,
0.0026572729,
0.019801958,
0.04678978,
-0.029886665,
-0.05013774,
-0.003487458,
0.009050379,
-0.03339794,
0.0071586454,
-0.021162916,
0.0146439215,
0.011949223,
-0.020006102,
0.036228735,
0.013425863,
0.004940282,
-0.01284065,
-0.02037356,
0.004290424,
-0.0077642724,
0.001837295,
-0.007954807,
-0.040202737,
0.0083086565,
0.041563697,
0.011500105,
0.028607363,
-0.011656616,
-0.009798907,
-0.021639252,
-0.003708614,
0.019107867,
-0.007383204,
-0.021122087,
0.0280902,
0.019298403,
-0.0025194758,
-0.0015268262,
0.017420279,
-0.0076553957,
0.016508436,
-0.0137661025,
0.0024769458,
0.0111734755,
-0.014807236,
0.011574958,
0.028199075,
0.04874956,
-0.020632142,
0.004246193,
0.009656006,
-0.0109353075,
-0.01701199,
0.008444753,
0.020237464,
0.00998944,
0.006903466,
0.011629397,
0.01054063,
-0.0063386676,
0.0095063,
0.020958772,
0.00783232,
-0.015896004,
0.020781849,
0.0065496163,
-0.0055391043,
0.00024412207,
0.024823897,
-0.013507521,
-0.01703921,
0.013065209,
0.006454349,
0.008587653,
-0.0038787338,
0.005600347,
0.011357205,
-0.023789568,
0.018196026,
-0.006127719,
-0.029614473,
0.0070837927,
0.017202524,
0.021829786,
0.028444048,
0.0005733041,
-0.008601262,
0.03769857,
0.0018168805,
0.025449937,
-0.015229134,
0.015474106,
-0.010574654,
0.025191355,
-0.009411033,
-0.02506887,
-0.018876504,
-0.027926885,
0.003922965,
-0.013446277,
0.013630006,
-0.021203745,
0.089387804,
0.018767629,
0.0022966187,
0.017896615,
-0.015719078,
0.013616397,
0.016209025,
-0.01769247,
-0.010812821,
-0.01318089,
0.026606753,
-0.0067401505,
0.017624423,
-0.025096089,
-0.00007958422,
0.012126147,
-0.023735128,
0.01938006,
-0.008825821,
-0.012806627,
-0.0010071099,
-0.03171035,
-0.0024854518,
-0.0020380365,
-0.021571204,
0.020251073,
0.0180191,
-0.012235024,
-0.0008361393,
-0.018985381,
0.008989136,
-0.0041169017,
-0.028552925,
-0.013248938,
-0.020591313,
0.017420279,
-0.025626862,
-0.01051341,
0.030322172,
0.027899664,
0.0016169897,
0.0038889411,
0.00933618,
-0.0019206537,
-0.004685102,
0.008505995,
0.0043278504,
0.006018842,
0.0119151985
] |
Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-associated nucleotide damage, including base loss (abasic site or 5'-dRP/AP sites). Ku, a 5'-dRP/AP lyase, can excise such damage at ends in preparation for the ligation step. We show here that this activity is greatest if the abasic site is within a short 5' overhang, when this activity is necessary and sufficient to prepare such termini for ligation. In contrast, Ku is less | [
-0.028188761,
0.006706843,
0.0065967306,
-0.040708203,
-0.03795873,
0.029096354,
0.007914742,
0.019192915,
0.00019050688,
0.0029012936,
-0.00888907,
0.009456315,
0.00171842,
0.013974258,
-0.020167243,
0.00195366,
0.028509088,
-0.006162955,
-0.0004763193,
-0.004037453,
-0.040441263,
-0.00024879552,
0.0022005786,
-0.015922913,
0.036277015,
0.020901326,
0.0044879126,
-0.024011165,
-0.0062930877,
-0.01169193,
0.0029747018,
0.013507115,
-0.012466053,
-0.013894176,
-0.009055907,
0.016430097,
0.010297173,
0.0018402109,
0.024811983,
-0.01046401,
0.021328429,
-0.0016058051,
-0.0019820223,
0.004240994,
0.00079748034,
-0.0000690809,
-0.0026026554,
-0.011024582,
-0.023317125,
0.015068708,
0.0046380656,
-0.0045012594,
-0.028989578,
-0.006813619,
-0.0049750763,
-0.01000354,
-0.006770241,
0.016149811,
-0.022689817,
-0.0031782428,
-0.017404424,
0.012712971,
-0.02666721,
0.017417772,
-0.014334626,
0.0042543407,
-0.0021288388,
-0.019473203,
-0.0018885937,
-0.006653455,
0.02465182,
0.012719644,
-0.012486073,
0.0074008848,
0.010343887,
-0.019032752,
-0.014815116,
-0.016136464,
-0.0051986375,
0.02127504,
0.02513231,
-0.016697036,
-0.030591212,
0.0110112345,
0.018966017,
-0.021074837,
-0.00748764,
0.0046147085,
-0.00014108144,
-0.0024858697,
-0.0059393933,
0.027414639,
0.024678513,
0.010630847,
-0.03905318,
0.03165897,
0.010283826,
0.0050484845,
-0.009509703,
-0.03168566,
-0.018725773,
-0.0053120865,
0.0019569967,
-0.008635477,
-0.003315049,
-0.0027127678,
-0.013867483,
-0.025025534,
0.013447054,
0.008161661,
-0.0049083414,
0.030324273,
-0.009743274,
-0.023410553,
0.019673407,
-0.033367377,
0.036917668,
-0.008955805,
-0.021995775,
-0.014521483,
0.021622062,
0.026974188,
0.0155625455,
-0.015455769,
0.020754509,
0.014107727,
0.0018368742,
-0.008101599,
0.0016224887,
0.0011052944,
0.019406468,
0.021048142,
0.012599522,
0.018138507,
-0.015549199,
0.022529654,
-0.0019052773,
-0.04295049,
-0.012546134,
-0.045086,
0.024491657,
0.02298345,
-0.003857269,
-0.004918352,
0.017017363,
0.018819202,
0.015882872,
-0.0070471903,
-0.005752536,
-0.0011661899,
0.009943479,
0.0005593207,
0.0039907387,
-0.013193461,
-0.007834661,
0.010710929,
0.0049950965,
0.034088112,
-0.012085664,
-0.028135374,
-0.005372148,
-0.022796594,
0.008935784,
-0.007220701,
0.002324038,
0.02906966,
-0.020247325,
0.008542049,
0.008068232,
-0.026960842,
0.018966017,
0.02513231,
-0.016069729,
0.020274019,
-0.0247319,
0.005418862,
-0.010450663,
0.02403786,
-0.028909497,
-0.0054956074,
-0.0012354272,
-0.008668845,
0.0095497435,
0.0068002716,
-0.00827511,
0.012205787,
0.011772011,
-0.010904459,
-0.017404424,
-0.0041208714,
0.014828463,
0.0009935137,
-0.015482464,
-0.024491657,
-0.6299761,
-0.022516306,
-0.0059994548,
0.004507933,
-0.008535376,
0.014654953,
0.03558297,
0.021728836,
0.000456716,
0.019513244,
-0.032459784,
0.0039907387,
0.015736056,
0.0027211097,
-0.03528934,
-0.013046645,
0.008415253,
-0.006660129,
0.009249438,
-0.015135443,
-0.015922913,
-0.006002791,
-0.039293423,
0.0030047325,
0.012072317,
-0.009676539,
0.04142894,
0.0046881167,
-0.008869049,
0.0016433434,
-0.019006059,
0.0074609458,
-0.022489613,
0.00035703095,
0.048235882,
0.027080964,
-0.019620018,
0.022756552,
0.020127203,
0.039293423,
-0.011324888,
-0.005438883,
0.024531696,
0.0138140945,
0.019646712,
-0.017364385,
0.015268913,
-0.0061763017,
-0.0031899214,
-0.00068069453,
0.006406537,
0.004150902,
-0.01173197,
0.023050185,
-0.018151853,
0.027708272,
-0.0083818855,
-0.02158202,
0.025372555,
0.018111814,
0.00073241396,
0.024464961,
-0.029363293,
-0.023810962,
-0.029656926,
-0.011738644,
-0.023770921,
0.0005142747,
-0.0028879466,
0.0012829757,
0.012359277,
0.007714538,
0.016016342,
0.0060828733,
0.017658018,
0.023984471,
-0.0029396662,
0.00171842,
-0.008208375,
0.013627238,
-0.002889615,
-0.016470138,
-0.022089204,
0.0041609122,
0.040201016,
0.0054755867,
-0.04241661,
0.014334626,
0.0113582555,
-0.01453483,
0.01795165,
0.0015791112,
-0.02158202,
-0.027681578,
-0.034248278,
0.021355122,
0.011812052,
0.0018485527,
-0.0007249063,
-0.008655498,
-0.0034802177,
-0.0072073536,
-0.008675518,
-0.0069604353,
0.014788422,
0.010851071,
-0.006406537,
-0.011638542,
0.043457672,
-0.029309906,
-0.020581,
-0.024198024,
0.010183724,
-0.010070275,
0.017484507,
-0.030644601,
0.016843854,
-0.007674497,
-0.008949131,
-0.039693832,
0.012552808,
-0.008835682,
-0.0049550557,
-0.02661382,
0.020581,
0.0077278847,
0.011958868,
-0.022276063,
0.0061028935,
-0.008215048,
-0.0005543156,
-0.0099568255,
0.01453483,
-0.0029747018,
0.011131357,
-0.008528702,
0.0013188457,
-0.0058726585,
0.010203744,
-0.0525336,
-0.023824308,
0.007167313,
0.0021421858,
0.008261763,
-0.024184676,
-0.014307932,
-0.023277083,
-0.00484828,
0.01860565,
0.015802791,
0.006693496,
-0.009576438,
-0.020901326,
0.016643649,
-0.007474293,
-0.01092448,
-0.01019707,
-0.030858152,
-0.038732853,
-0.011531766,
0.0029913855,
0.004240994,
0.0013864146,
-0.00078663597,
-0.009996867,
-0.02179557,
0.028962884,
-0.016403403,
0.007807967,
-0.019246304,
-0.009569764,
-0.006072863,
-0.026440311,
-0.023357164,
0.0022539664,
0.0013822437,
-0.0076811705,
0.0071873334,
0.01602969,
0.011605174,
-0.0054422193,
-0.006376506,
-0.004648076,
-0.02599986,
0.0062396997,
0.024398226,
0.017404424,
-0.0013764043,
0.021141572,
0.020607693,
-0.0027878445,
0.0046280553,
-0.015509157,
0.014307932,
-0.0012245828,
-0.0010652535,
0.013647257,
0.02284998,
0.002048757,
0.03446183,
0.039720528,
-0.008034864,
0.015402382,
-0.024838677,
0.020274019,
-0.019326385,
0.017738098,
-0.0028462373,
0.015295606,
-0.010383928,
-0.029603539,
-0.014828463,
-0.021288387,
-0.011812052,
0.021315081,
-0.00038309922,
-0.010897785,
0.00985005,
-0.00720068,
0.0008959141,
-0.0005055158,
-0.014641605,
0.017497852,
0.006703506,
-0.012105685,
0.005205311,
0.02079455,
0.013527135,
-0.017938303,
-0.012612869,
-0.004584678,
-0.010270479,
-0.014214504,
0.008315151,
0.01869908,
0.0256128,
0.007087231,
0.0046280553,
0.035182565,
-0.004127545,
0.0026577117,
0.0102504585,
0.0075410274,
-0.001895267,
0.030671295,
0.008508681,
0.03638379,
0.022142593,
-0.028162068,
0.012853114,
-0.0094896825,
0.032940276,
-0.00936956,
0.02968362,
0.002862921,
-0.026200065,
0.018005038,
0.048235882,
0.05437548,
0.017150832,
0.0016767108,
-0.0108310515,
0.0108911125,
0.0036704117,
0.0034935644,
-0.023397205,
-0.0055389847,
-0.0013497105,
-0.018979365,
0.0012954884,
0.0017584609,
-0.033821173,
-0.004534627,
-0.027734965,
0.022729859,
0.005865985,
-0.00171842,
0.03003064,
0.027334556,
0.0029696967,
-0.018725773,
-0.037504934,
0.04658086,
0.023690838,
-0.010544091,
-0.01263289,
-0.024478309,
-0.0047148108,
-0.0036837587,
0.01925965,
-0.0020837928,
0.018632345,
0.024558391,
0.011945521,
-0.009636499,
-0.031151785,
0.021969082,
-0.016817158,
0.038412526,
-0.02947007,
0.006386516,
0.004337759,
-0.021595368,
-0.013540482,
0.05183956,
0.017217567,
0.005115219,
0.0029913855,
0.02329043,
-0.037237994,
-0.022049164,
-0.010931153,
0.0056924745,
-0.027574802,
-0.008915763,
0.003550289,
0.001673374,
0.00060436665,
0.021782225,
-0.013707319,
-0.008655498,
-0.018458834,
0.0037838607,
-0.0033200542,
0.029523456,
-0.0068670064,
-0.003024753,
0.026907453,
0.020901326,
0.024571737,
0.012506094,
-0.033741094,
0.019459855,
-0.021168265,
0.02325039,
0.0036070137,
0.007514334,
0.00735417,
0.020874633,
0.027654883,
0.01689724,
-0.032166153,
-0.0020237316,
0.012359277,
-0.0073141293,
-0.005685801,
0.017417772,
0.03926673,
0.012793053,
0.02981709,
0.021128224,
-0.014961933,
0.016323322,
-0.006323118,
-0.007113925,
0.012786379,
0.010096969,
0.02246292,
-0.008615457,
-0.029923866,
0.006680149,
-0.019366426,
0.026587127,
0.010270479,
0.00374382,
0.017044056,
0.018899282,
0.008782294,
0.015922913,
-0.020247325,
-0.004187606,
0.010283826,
-0.026039902,
-0.0024024514,
0.016363362,
-0.031338643,
-0.03825236,
-0.0033484164,
0.006706843,
-0.009229417,
0.0090225395,
-0.0010385597,
-0.005765883,
-0.022449572,
0.01689724,
-0.016256588,
0.013073339,
0.0025175686,
-0.004471229,
-0.022342797,
-0.020100508,
-0.025572758,
-0.0066901594,
-0.02127504,
-0.003997412,
-0.0064332304,
-0.028375618,
-0.0050685047,
0.014614912,
-0.004331086,
0.017871568,
0.0019336396,
-0.0035669727,
0.010110316,
-0.021501938,
-0.0069337413,
0.0020454202,
-0.016403403,
-0.0148017695,
-0.011685256,
-0.0012746338,
-0.008348518,
-0.01000354,
0.00053429516,
0.017084097,
-0.0052453517,
0.012779706,
0.018138507,
-0.019339733,
0.012773032,
0.021955734,
0.039640445,
-0.003920667,
0.0037304729,
-0.013386992,
-0.033874564,
-0.013513789,
-0.023477288,
-0.0054021785,
-0.02736125,
-0.018632345,
0.014988626,
-0.00026130828,
-0.013393666,
0.02732121,
-0.014735035,
0.006833639,
0.0042209732,
0.03235301,
0.039827302,
0.01829867,
0.014748381,
-0.0048582903,
0.012472726,
-0.0028729313,
-0.037932035,
0.027000884,
-0.0054956074,
-0.01234593,
0.032272927,
0.007561048,
-0.03857269,
0.004671433,
-0.009683213,
-0.005929383,
0.028001904,
-0.000515526,
-0.020847939,
-0.015295606,
-0.015108749,
-0.010210418,
0.0024408237,
-0.011758665,
-0.006006128,
-0.013800748,
0.0027110996,
0.01079101,
-0.013507115,
-0.014267891,
-0.024478309,
-0.0012879808,
0.03318052,
-0.0010377255,
-0.021261694,
-0.014214504,
-0.00028654237,
-0.025666188,
-0.022129245,
-0.010524071,
-0.018405447,
0.013894176,
0.00073241396,
0.02981709,
0.052213274,
0.037665095,
-0.017084097,
0.00067819195,
0.016163157,
0.00037434028,
-0.0034668706,
-0.011992236,
0.000105837156,
-0.028429007,
0.010897785,
0.027628189,
-0.016336668,
0.0059894444,
0.006069526,
0.008201702,
0.027201086,
-0.0057225055,
-0.03659734,
0.01825863,
-0.030911539,
0.00195366,
0.012606195,
-0.010710929,
-0.0097232545,
-0.023810962,
-0.0018568946,
0.00406081,
0.019926999,
0.005121893,
-0.022129245,
0.02609329,
0.016803812,
0.023076879,
0.0117119495,
0.012779706,
-0.025546065,
-0.00020281109,
0.0008575416,
0.017631322,
-0.0056090564,
0.0019169559,
0.0029313243,
-0.030484436,
-0.015402382,
-0.00469479,
-0.0059126993,
-0.017684711,
-0.03187252,
0.015682667,
-0.014134422,
-0.019326385,
0.0012954884,
0.019566631,
-0.037665095,
0.0021088184,
-0.001076098,
0.0020771194,
0.008875723,
-0.0051085455,
-0.011478378,
0.017017363,
-0.0034468502,
-0.0004500425,
-0.026653862,
0.016350016,
0.0033567583,
0.016096424,
-0.04092175,
-0.014775075,
0.0076811705,
-0.0017601292,
0.011858766,
0.0074409256,
0.0054422193,
-0.0067268633,
-0.015202178,
0.0043244124,
-0.019473203,
-0.044578817,
0.02000708,
-0.009069254,
0.012012256,
0.0033617634,
0.009356213,
-0.0035936667,
0.034274973,
-0.008575416,
0.034088112,
0.00343684,
-0.0059260465,
-0.025078923,
0.034648687,
0.007534354,
0.011972215,
-0.012359277,
-0.0055156276,
-0.010177051,
-0.025092268,
-0.0057625463,
0.014334626,
-0.0016433434,
0.035235953,
-0.022916716,
-0.011438337,
0.0045279535,
0.0050951988,
-0.0014531494,
-0.016176505,
0.013547156,
0.037531625,
-0.009309499,
-0.00936956,
0.006813619,
0.018659038,
0.022089204,
0.0012037281,
-0.0010844398,
-0.021555327,
-0.036330402,
0.00844862,
0.0077345585,
-0.0019920324,
-0.007807967,
-0.019900305,
-0.013974258,
-0.0017901598,
-0.011371602,
-0.011825399,
0.03849261,
-0.036170237,
-0.020300712,
-0.019099487,
-0.0011161388,
0.01514879,
0.011458358,
0.000434193,
-0.004441198,
0.013580523,
-0.014027646,
-0.005725842,
0.008401906,
0.023223696,
0.0055456585,
0.0019970376,
-0.011785358,
-0.008655498,
0.013160094,
-0.014481442,
-0.026240107,
0.0050418107,
-0.010443989,
0.014508137,
0.017871568,
-0.012332583,
0.0058226073,
-0.020634387,
0.023650797,
0.016309975,
-0.035502892,
0.029042967,
-0.01860565,
0.016283281,
0.026960842,
-0.01672373,
-0.034782156,
0.00095347286,
-0.0138140945,
-0.023450594,
-0.024705207,
-0.0071472926,
-0.008134967,
-0.011485051,
0.007447599,
0.0015457438,
0.0060561793,
-0.013513789,
-0.030991621,
0.013854136,
-0.0028679261,
0.0000022663098,
0.002807865,
0.0025492676,
-0.009396254,
0.026160024,
-0.018245282,
-0.0108310515,
0.0007090568,
-0.005689138,
-0.022382837,
0.004177596,
-0.012072317,
0.054188624,
0.022703165,
-0.022876674,
-0.008575416,
-0.018618997,
-0.036437176,
-0.010590806,
-0.0038272382,
0.0023223695,
-0.003500238,
0.0072340476,
0.002252298,
0.0036503912,
0.0031632276,
0.001008529,
-0.0025475994,
-0.02127504,
0.023410553,
-0.0021455225,
0.01856561,
0.02284998,
-0.028615864,
-0.0058960156,
0.013800748,
0.015082055,
-0.0049784128,
0.01610977,
0.015228871,
0.01659026,
0.012439359,
0.009763295,
0.03384787,
0.028509088,
0.013427033,
-0.04316404,
-0.0038339118,
0.028375618,
0.0067635677,
-0.032860193,
0.003757167,
0.0004892492,
0.00468478,
-0.0020554306,
-0.0131133795,
-0.023503982,
-0.009236091,
-0.05573687,
0.008335171,
0.004471229,
-0.005705822,
0.018845895,
0.007921415,
-0.01436132,
-0.0053354437,
-0.02797521,
-0.03555628,
-0.010564112,
0.018872589,
-0.02219598,
-0.014868503,
-0.011932175,
0.009529723,
-0.021328429,
-0.0040140958,
0.01576275,
-0.015429076,
-0.021942388,
0.008301804,
-0.0109511735,
-0.0014865167,
0.0056557707,
0.024464961,
-0.023971125,
0.008215048,
0.016817158,
0.020807898,
-0.021595368,
0.020941367,
-0.005498944,
-0.01470834,
-0.017417772,
0.009890091,
-0.023143614,
-0.010183724,
0.013960911,
0.20255333,
-0.0032416407,
0.017284302,
0.0045413002,
0.010570786,
-0.02333047,
-0.015202178,
-0.009469662,
-0.023036838,
-0.006406537,
0.02499884,
0.0077679255,
-0.036036767,
-0.008495335,
0.049490497,
-0.0113582555,
-0.029523456,
-0.002133844,
-0.016189853,
0.025038881,
0.0101303365,
0.0054922705,
-0.0050885254,
-0.00019123679,
0.019766835,
0.002324038,
-0.02039414,
0.006213006,
-0.0066034044,
0.017004017,
-0.03769179,
-0.0024124614,
0.006159618,
0.015442423,
0.019633366,
-0.006489955,
-0.010417296,
-0.011785358,
0.008281783,
0.011118011,
0.013480421,
0.0049750763,
-0.004621382,
-0.0030881509,
-0.0031298602,
-0.018405447,
0.017684711,
-0.028215455,
-0.020540958,
0.01169193,
-0.060434997,
-0.007447599,
0.008175008,
0.028509088,
0.0008975825,
0.00983003,
0.0009935137,
0.006927068,
0.01602969,
0.044445347,
0.006006128,
0.020754509,
-0.025599454,
0.020460876,
-0.033741094,
0.032513175,
-0.017591283,
-0.008188355,
0.046313923,
-0.006022812,
0.01589622,
-0.012926523,
-0.002278992,
0.0035602993,
-0.020060468,
-0.035342727,
0.026787331,
0.03440844,
0.018205242,
-0.005485597,
0.02280994,
-0.013313584,
0.0029229824,
-0.0020070479,
0.0036637383,
-0.010270479,
0.0007557711,
0.000111467896,
-0.015348994,
-0.006479945,
0.011878787,
-0.010297173,
-0.0087556,
-0.0144547485,
-0.019379774,
0.010390602,
-0.0049283616,
0.0010285494,
-0.025185697,
0.0028328905,
-0.027681578,
0.061556138,
-0.011531766,
0.006182975,
-0.011491725,
0.006366496,
-0.010824378,
0.021862306,
-0.0048549534,
0.013840789,
0.032566562,
-0.013934217,
0.015749402,
-0.0010635852,
-0.00453129,
0.02885611,
0.0017200884,
-0.031045008,
0.02394443,
0.004034116,
-0.0073208027,
-0.016096424,
-0.008522028,
0.028482394,
-0.016950628,
0.016203199,
-0.021969082,
0.002369084,
-0.022796594,
-0.027761659,
-0.010177051,
0.012706297,
0.011878787,
-0.00036287025,
0.004874974,
-0.008375212,
-0.007807967,
-0.026987536,
-0.008235069,
0.002369084,
0.012212461,
0.008882396,
0.022596389,
0.014254544,
-0.0006986295,
-0.016403403,
0.030778069,
0.003251651,
-0.02858917,
-0.021622062,
-0.032806806,
0.004024106,
0.0067902617,
-0.014081034,
0.0028262169,
-0.0148017695,
-0.028295537,
-0.013867483,
0.00467477,
0.034915626,
-0.042149674,
0.014267891,
0.02329043,
-0.024224717,
-0.0069804555,
-0.0062563834,
-0.16806482,
0.0061896485,
0.018325364,
-0.02106149,
0.011845419,
0.04719482,
0.027628189,
0.0076077622,
-0.005392168,
0.010764317,
0.008869049,
0.0028228802,
-0.04623384,
-0.02521239,
-0.0012771364,
0.01562928,
0.018979365,
0.00023774257,
0.0159763,
0.003500238,
-0.00045713308,
-0.020300712,
0.028348925,
-0.0002667305,
-0.006590057,
-0.003093156,
-0.0025075586,
-0.011498399,
-0.005936057,
-0.004267688,
-0.014761728,
0.016002994,
0.02144855,
0.0029730333,
0.0136939725,
0.0085553955,
-0.015869524,
0.01917957,
0.009916785,
0.016817158,
0.02885611,
0.025813004,
0.002817875,
-0.012646236,
0.00007200055,
0.010497377,
0.019139528,
-0.0175112,
0.027788352,
-0.0010727613,
0.011344909,
-0.014000952,
0.012399318,
0.014948586,
0.018218588,
0.011344909,
-0.003111508,
0.021862306,
-0.010984541,
-0.008782294,
-0.008895743,
-0.0018402109,
0.032539867,
-0.007834661,
-0.008922437,
-0.028135374,
-0.00060978887,
0.008261763,
-0.032806806,
0.01173197,
-0.027841741,
-0.013427033,
0.0022189307,
-0.00750766,
0.0159763,
0.009055907,
-0.003924004,
0.025853045,
-0.016763771,
-0.02534586,
-0.002699421,
0.038172282,
-0.014201156,
-0.032726724,
-0.013560503,
0.003780524,
-0.011978889,
0.0008220888,
-0.008074906,
-0.0023307113,
0.012392645,
-0.027921822,
0.023570716,
-0.011278174,
0.024224717,
0.010243786,
0.007294109,
-0.017844874,
0.007647803,
0.015869524,
-0.010570786,
-0.008835682,
0.0013113379,
0.013313584,
0.028295537,
-0.0023640788,
0.0016883893,
-0.00040186837,
0.02534586,
0.011685256,
-0.013920871,
-0.023584062,
0.018218588,
0.010991215,
-0.008161661,
0.028615864,
-0.015108749,
0.01777814,
0.01484181,
-0.019419814,
0.063157775,
-0.0030714672,
-0.019926999,
-0.0011653557,
0.006313108,
-0.022075858,
-0.12684943,
-0.01812516,
0.025572758,
0.019953692,
-0.014828463,
0.018098466,
0.014988626,
0.035262644,
-0.013653931,
0.026426964,
-0.042977184,
-0.00500177,
0.0033017022,
-0.007841334,
-0.0068002716,
0.0071339454,
0.00048466117,
-0.015122096,
-0.02158202,
0.024424922,
-0.02521239,
0.011378276,
0.0028862783,
-0.018992713,
0.00056557707,
-0.0017751445,
-0.024825329,
0.034568604,
0.0087556,
0.0005580694,
-0.005278719,
-0.013880829,
0.018618997,
-0.0013872487,
-0.009276131,
-0.026253453,
-0.0041642487,
-0.009122641,
0.044578817,
-0.01877916,
-0.021395164,
0.0006698501,
0.014588218,
0.0042076265,
0.0037471566,
-0.011344909,
-0.0076411297,
0.010103642,
-0.0062163426,
0.003880626,
-0.029389987,
-0.021034796,
-0.03488893,
-0.021768877,
0.03205938,
-0.02263643,
0.007714538,
0.014347972,
-0.017844874,
-0.007974803,
0.0023490635,
-0.020153897,
-0.02386435,
-0.005458903,
0.024331493,
-0.0032900234,
-0.010871092,
-0.014347972,
0.02928321,
0.0032616612,
0.0097833155,
0.01952659,
-0.004134218,
0.014654953,
-0.028669251,
-0.0007991487,
-0.03192591,
-0.014241197,
-0.005552332,
0.004381137,
0.0012437691,
-0.02144855,
0.010443989,
-0.018045079,
-0.0013797411,
-0.00027277833,
-0.019913651,
0.008328497,
0.029229823,
-0.015615934,
0.0028112016,
0.035396114,
-0.00055014464,
-0.014428055,
-0.0067402106,
0.028642558,
0.00065233227,
-0.012392645,
0.014321279,
0.008795641,
-0.007921415,
0.0094896825,
-0.04943711,
0.015108749,
-0.00087255694,
0.0003970718,
0.005081852,
-0.025599454,
0.034435134,
-0.0057892404,
-0.0102905,
0.006927068,
-0.02434484,
0.0071339454,
-0.010584133,
-0.025946474,
-0.027468026,
-0.00008456545,
0.020514265,
-0.016323322,
0.009476336,
0.025946474,
0.014641605,
-0.010323867,
0.0129932575,
0.0061796387,
-0.0054522296,
0.0037204628,
0.009276131,
0.01584283,
-0.002786176,
-0.0087289065,
0.008829009,
-0.046874493,
-0.021822266,
0.011978889,
-0.013760707,
-0.009576438,
-0.022890022,
0.028509088,
0.016737077,
0.03435505,
-0.02640027,
-0.02872264,
0.008748926,
0.009643173,
-0.018952671,
0.0026660536,
-0.0159763,
0.01169193,
-0.00016892236,
-0.02674729,
0.050718416,
0.006046169,
0.00515526,
-0.020834591,
-0.016563566,
0.001686721,
0.006236363,
-0.01234593,
0.0031465439,
-0.029843783,
0.019406468,
0.012512767,
0.019072793,
0.014654953,
0.0030130742,
0.001578277,
-0.012719644,
-0.01703071,
0.0004102102,
-0.03576983,
-0.020954713,
0.026373576,
-0.020073814,
0.0038639423,
-0.002143854,
0.01326687,
-0.01983357,
0.009262784,
-0.011645215,
-0.019019406,
0.0074542724,
-0.019006059,
0.00343684,
0.019139528,
0.0056557707,
-0.019099487,
0.00060061284,
0.022996798,
-0.0045679943,
0.015869524,
-0.0033100438,
0.023931084,
0.006499965,
0.035342727,
-0.020981407,
0.018218588,
-0.022569695,
-0.004658086,
0.00032345502,
0.012359277,
-0.016069729,
-0.006476608,
0.008735579,
-0.020981407,
-0.0074275783,
0.05616397,
-0.02534586,
-0.012686278,
0.010343887,
0.010917806,
0.016056383,
0.010911133,
0.01232591,
0.01344038,
0.0045112697,
0.005535648,
0.005642424,
-0.023050185,
-0.016216546,
0.02246292,
0.0061796387,
0.019232957,
-0.0000680903,
0.014347972,
0.043644533,
0.0019252978,
0.031285252,
-0.013800748,
-0.008688865,
-0.016803812,
0.030270886,
-0.014588218,
-0.056804623,
-0.0014673305,
-0.011545113,
-0.0080882525,
0.017137486,
0.025319166,
-0.016256588,
0.0897449,
0.022436226,
-0.023423899,
0.0048215864,
-0.026760638,
0.03179244,
-0.011785358,
-0.0034201562,
0.014788422,
-0.036063462,
0.0084419465,
-0.0104239695,
0.02311692,
-0.014735035,
-0.012639563,
-0.012212461,
0.010363908,
0.010076948,
-0.02110153,
-0.0024174666,
0.028749334,
-0.015709361,
-0.002519237,
0.019339733,
-0.03625032,
0.015188831,
0.027161047,
-0.019913651,
0.02219598,
-0.026680555,
0.0017467822,
0.0011970547,
-0.04225645,
-0.0063698324,
0.0047648614,
0.0031315284,
0.0003568224,
-0.002944671,
0.03446183,
0.0027194414,
0.019780181,
0.005191964,
-0.000086755186,
-0.036944363,
-0.009543071,
0.013473747,
-0.01825863,
0.020847939,
-0.008215048
] |
Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors, the taste G protein gustducin, and several other taste transduction elements. Mouse intestinal L cells also express alpha-gustducin. Ingestion of glucose by alpha-gustducin null mice revealed deficiencies in secretion of GLP-1 and the regulation of plasma insulin and glucose. | [
-0.00722607,
-0.013517621,
0.026614051,
-0.02456074,
-0.008706822,
0.0009106625,
-0.0036492313,
-0.007601194,
-0.011049701,
-0.016308017,
0.027824977,
0.00481738,
-0.032984573,
0.010483725,
-0.013260958,
0.0062783887,
0.04188225,
-0.0053669037,
-0.011740719,
0.019256359,
-0.014399491,
0.009595273,
0.004540973,
-0.005146436,
0.011799948,
-0.00493255,
-0.0006482403,
-0.02943077,
0.0018114534,
-0.010227061,
0.019309007,
0.01703194,
-0.026442941,
0.03877596,
0.012050032,
-0.004471871,
-0.0005219651,
0.00061944796,
0.0074103414,
-0.00027167686,
0.019690713,
0.027324812,
0.0076275184,
-0.000101081896,
-0.010582441,
0.012800279,
0.014149409,
-0.0049457117,
-0.013491296,
0.0052385717,
0.00019506853,
0.0026801613,
-0.022217862,
-0.028167196,
-0.018492948,
0.0016773631,
0.01480752,
0.009766382,
-0.00009326681,
-0.03490626,
0.007180002,
-0.003083255,
-0.01915106,
0.004063842,
0.02866736,
0.015268199,
-0.004550845,
0.012912158,
0.007008893,
0.0066765468,
0.014030948,
0.024336983,
-0.0033086583,
0.018479787,
0.035090532,
-0.025745343,
-0.023007596,
-0.0070747044,
0.0050411383,
0.017400483,
0.03119451,
-0.010470563,
-0.017532105,
0.052201446,
0.002884176,
-0.0066173165,
-0.0028249458,
0.008160589,
-0.019782847,
-0.008127684,
-0.00093945494,
0.006630479,
0.027535407,
0.03640676,
-0.016650235,
0.011681489,
-0.010872011,
0.025640044,
0.016781857,
-0.033379443,
-0.011898666,
0.027324812,
-0.016755532,
-0.013780866,
0.001915106,
-0.0068180407,
0.00898981,
-0.023402464,
0.03306355,
0.0022129016,
-0.024060575,
0.030352127,
-0.014438978,
-0.022994434,
0.0026916782,
-0.004162559,
0.011549866,
0.00575519,
0.005797967,
-0.017926972,
0.022810163,
0.01709775,
0.02291546,
-0.0145706,
0.019717036,
0.02456074,
0.014320518,
-0.0021980943,
-0.017861161,
-0.012418574,
0.015031279,
-0.0036196162,
0.018993113,
0.013359674,
-0.017321508,
0.0095426245,
-0.017755862,
0.0015054313,
-0.0120763555,
-0.015636742,
0.011135256,
0.04211917,
0.004504777,
0.021717697,
-0.02120437,
0.018045433,
0.039513048,
0.015531444,
0.012958226,
-0.001583582,
0.0044850335,
-0.018453462,
-0.0027887498,
-0.0022902298,
0.030825967,
0.021335993,
0.016531775,
0.033405766,
0.0023774297,
-0.0076867486,
-0.0052583152,
-0.039749965,
0.0013581787,
0.0054722014,
0.009799289,
0.029562393,
0.018598245,
-0.007054961,
-0.0014108276,
-0.01074697,
-0.003435345,
0.03764401,
-0.02373152,
0.016400151,
-0.043461718,
0.028009249,
0.014728547,
0.019822335,
-0.001298126,
0.0075682886,
-0.027351135,
0.025455773,
0.007903925,
0.009114851,
-0.013504459,
-0.01862457,
0.00798948,
-0.012517291,
0.0049259686,
-0.037091196,
-0.0011401791,
0.017045101,
-0.0055281413,
-0.038038876,
-0.628418,
-0.023323491,
0.03614351,
-0.003800597,
-0.014267869,
0.035511725,
0.00020895057,
-0.021046422,
-0.007160259,
-0.0023313619,
0.002708131,
0.016597586,
0.021638723,
-0.04035543,
-0.015794689,
-0.033642687,
-0.003800597,
-0.008114521,
0.024073739,
-0.004846995,
-0.02743011,
0.0035505143,
-0.0053010923,
0.019480117,
0.023784168,
0.005146436,
0.011326108,
-0.010200736,
-0.041434735,
0.012207978,
-0.013188565,
0.0016074387,
-0.0025353767,
-0.0052616056,
0.051490687,
0.0029466967,
-0.015452471,
-0.008548875,
-0.0029220174,
0.0659165,
-0.022797002,
0.0013425485,
0.011062863,
0.01745313,
-0.027272163,
0.004024355,
0.018664056,
0.04264566,
0.010292872,
-0.0027163574,
0.012207978,
0.015649904,
-0.023863142,
0.016123746,
0.034748316,
0.018190216,
0.031721,
-0.0132675385,
0.0064297547,
0.008404091,
0.01633434,
0.03195792,
-0.026521916,
-0.012879252,
0.008759472,
0.01368873,
-0.013432067,
0.001967755,
0.023099732,
0.021836158,
0.02843044,
0.02074369,
0.004886482,
0.021954617,
0.018808842,
0.015544606,
-0.0007169308,
0.035459075,
-0.004159268,
0.007061542,
-0.010141507,
0.011503798,
-0.005857197,
0.0056071146,
0.02790395,
0.002866078,
-0.005268187,
0.015505119,
-0.010167831,
0.010569279,
0.020164553,
0.020256689,
-0.009509719,
-0.0069694063,
-0.023639385,
0.018848328,
-0.030167855,
0.00370188,
0.020401472,
-0.022731189,
-0.005100368,
-0.01926952,
-0.0024169164,
-0.00074695714,
0.03882861,
-0.0012594619,
-0.030825967,
-0.0005783159,
0.042461388,
-0.027509082,
-0.0062059965,
-0.008555456,
-0.012214559,
0.0050246855,
0.0064001395,
-0.008088197,
0.025719019,
0.0068641086,
-0.01984866,
-0.029694015,
0.0069562444,
-0.025113555,
0.0057189935,
0.0012405412,
-0.00003485937,
-0.0017818384,
0.011773624,
-0.012563359,
0.005656473,
0.0023428788,
0.001451137,
0.010740388,
0.019440629,
-0.007601194,
0.009496557,
0.014465302,
0.03177365,
-0.005100368,
0.017229373,
-0.03416918,
-0.01755843,
-0.015676228,
0.0034978655,
-0.012938483,
0.005774933,
0.020177715,
-0.015149739,
-0.0026999046,
0.010036209,
-0.0085883625,
-0.0045146486,
-0.017413644,
-0.011977639,
0.019690713,
0.018071756,
-0.009647923,
-0.00645937,
-0.015728878,
-0.008660754,
-0.0009435681,
0.007555126,
0.012069775,
0.006186253,
-0.0016724272,
-0.0041263625,
-0.022546919,
0.024165874,
0.0085752,
0.0031112246,
-0.046620656,
0.0055709183,
-0.0073379492,
-0.01368873,
0.024363307,
-0.0052879304,
0.0073182057,
-0.008601524,
0.004333668,
-0.005709122,
-0.009884843,
0.0027854592,
-0.015176063,
-0.011148418,
0.008088197,
0.03864434,
0.00657783,
0.019690713,
0.039855264,
-0.008706822,
0.0050444286,
-0.015768364,
0.019835496,
-0.013912489,
0.018716706,
-0.015307686,
-0.012885833,
-0.007443247,
0.0007288591,
-0.0004952293,
0.012201397,
0.020111904,
-0.018900977,
0.0005421198,
-0.023823656,
0.032300137,
-0.033563714,
0.0052089565,
-0.018650895,
0.016716046,
0.016650235,
0.0028940476,
0.0061336043,
-0.003494575,
-0.013010875,
0.010240223,
0.014636411,
-0.0052780584,
-0.011319527,
-0.0122277215,
-0.018282352,
-0.00018386004,
0.0055972426,
0.016242204,
-0.010180993,
-0.007397179,
0.04135576,
0.012346182,
0.0073576923,
-0.03406388,
-0.028114546,
-0.0004602671,
-0.0024103352,
-0.0051892134,
0.0039552534,
-0.003665684,
0.0006062857,
0.008917418,
-0.005610405,
0.008976649,
0.031931594,
0.013794028,
0.012115843,
0.01979601,
0.013366255,
-0.0076275184,
-0.010023046,
-0.001956238,
0.007699911,
-0.023652546,
0.024981933,
0.0072918814,
0.021546587,
-0.024955608,
0.0005240217,
-0.012017125,
0.008331698,
0.017729538,
0.002356041,
0.0146758985,
0.025797991,
-0.008114521,
-0.0035472238,
-0.0050937873,
-0.031089213,
-0.0009016135,
0.0093912585,
0.002454758,
0.0021980943,
-0.0095426245,
0.0002936825,
-0.025350476,
0.0012528808,
0.015768364,
-0.03482729,
0.021164883,
0.024521254,
0.024284335,
-0.009832194,
0.011635421,
-0.0019545928,
0.0069759875,
-0.028404115,
0.03024683,
0.019282682,
0.0021980943,
-0.003948672,
-0.03706487,
-0.011503798,
-0.001668314,
0.0049917796,
0.0094110025,
0.009601855,
0.027035242,
-0.0064231735,
-0.023520924,
-0.0025074068,
-0.009503137,
-0.012675238,
0.0054030996,
0.011648583,
0.006021725,
0.010865429,
-0.020598907,
-0.017216211,
0.05017446,
0.025271501,
-0.008983229,
-0.022981273,
0.015478795,
-0.016900318,
-0.00006195508,
-0.0022013849,
0.011799948,
-0.021125397,
0.018703545,
0.016110582,
-0.009674246,
0.018756192,
0.021533426,
-0.0132675385,
-0.051122144,
-0.027351135,
-0.016400151,
0.006943082,
0.0135702705,
0.014425816,
-0.0051168213,
-0.0014963823,
-0.014886494,
0.0009657794,
-0.021243857,
-0.022704866,
0.010950984,
-0.010700902,
-0.016900318,
0.018993113,
-0.011622258,
-0.0061566383,
0.02631132,
-0.013543946,
-0.019348493,
-0.042856257,
-0.004768022,
0.010444238,
0.025192529,
0.0152813615,
0.012543615,
0.0158605,
-0.008509388,
-0.012194816,
-0.0010620283,
0.0096281795,
0.0016419896,
0.0010661415,
0.0013409032,
-0.008246143,
0.018900977,
-0.008061873,
-0.038381092,
-0.03853904,
0.025758505,
0.00003455088,
0.017400483,
0.005797967,
0.010720645,
0.018177055,
-0.0066008638,
0.00928596,
-0.017532105,
-0.015505119,
-0.018519273,
0.03095759,
-0.017308347,
0.0015366916,
0.019124735,
-0.01815073,
0.013320187,
-0.024468604,
0.00710761,
0.0054261335,
-0.0036854274,
-0.006396849,
-0.010878592,
-0.013912489,
-0.005564337,
-0.019295845,
0.005422843,
-0.0033645977,
-0.005340579,
-0.009035878,
0.0036821368,
-0.032879278,
-0.00053924054,
0.008713404,
0.015728878,
-0.035643347,
-0.0038367931,
0.015399822,
0.0082198195,
0.0018295514,
0.014649574,
-0.005133274,
0.0026456104,
0.013557108,
-0.011951314,
-0.024429118,
0.00011619791,
-0.022546919,
0.03187895,
0.0017900647,
0.019466953,
-0.019651225,
-0.015676228,
-0.014794358,
-0.009371515,
-0.012977969,
0.013859839,
-0.012240884,
-0.014886494,
-0.0098651,
0.01984866,
0.008739728,
0.012589683,
0.009180663,
-0.003971706,
-0.020138228,
-0.04912148,
-0.022941785,
0.0014700578,
-0.0024925994,
0.014070435,
0.011997382,
-0.010200736,
-0.0067357766,
0.008529132,
0.0022836488,
0.0053767753,
0.011359014,
0.0018641023,
0.029878287,
-0.021099072,
0.018348163,
0.004501486,
-0.027298488,
-0.017992783,
-0.009713734,
0.019598577,
-0.007884182,
-0.01874303,
0.00516947,
-0.00440606,
-0.009615017,
-0.015439308,
-0.00898981,
0.008410672,
0.022731189,
0.011799948,
-0.010648252,
-0.023981603,
0.0060315966,
-0.039381426,
0.0060941176,
-0.01815073,
-0.018019108,
-0.03072067,
-0.0051859226,
0.019769685,
-0.019703874,
0.014583763,
-0.023165543,
0.0017242535,
-0.0040309364,
0.002384011,
0.0040210644,
0.019124735,
0.011655164,
-0.03511686,
-0.0027459725,
-0.013899326,
-0.033484742,
-0.021164883,
-0.011793368,
0.016294854,
0.01703194,
0.03830212,
-0.0045541353,
0.01374138,
0.008535713,
-0.0005626858,
0.0279566,
-0.017110912,
0.0013935523,
-0.01609742,
0.0114906365,
-0.012787117,
-0.02096745,
0.02313922,
-0.00012277902,
0.015899986,
0.002384011,
-0.0064988565,
-0.015452471,
-0.01286609,
-0.029325472,
-0.021888806,
0.014768034,
-0.013728217,
0.0004746633,
-0.018703545,
-0.031141862,
0.03516951,
0.010477143,
0.0071997456,
-0.022665378,
0.030799644,
-0.043224797,
0.03846007,
0.012089518,
-0.009187244,
-0.008785795,
-0.031141862,
0.0153471725,
-0.00593288,
0.012668656,
0.0030388322,
0.0015959217,
-0.011003633,
-0.033537388,
-0.013063524,
-0.002662063,
0.0008325117,
-0.004399479,
-0.026508752,
-0.0074169226,
-0.0106679965,
-0.014662736,
-0.02302076,
-0.05733472,
-0.014702223,
0.018914139,
-0.013089849,
0.019414306,
-0.01409676,
-0.01662391,
0.019835496,
0.007219489,
0.026824646,
0.00009228993,
0.02590329,
0.01862457,
0.0112537155,
-0.008180332,
0.0013203373,
-0.0048042177,
-0.0066929995,
0.023297166,
0.0044850335,
0.024284335,
-0.013701892,
-0.0122277215,
0.042092845,
-0.01392565,
-0.021954617,
0.003265881,
0.01862457,
-0.008002643,
-0.01757159,
-0.020046093,
-0.0016288273,
0.007331368,
0.005409681,
-0.0043863165,
-0.009522881,
0.01533401,
-0.023112895,
0.03066802,
0.026232345,
0.00052031985,
-0.0111879045,
0.012082937,
0.008384347,
-0.029009579,
-0.034037553,
-0.0056433105,
-0.0038664083,
0.0014371522,
-0.008706822,
0.0024893088,
0.0008374476,
-0.014478465,
0.027061567,
-0.000055579618,
0.002184932,
0.033563714,
-0.010523211,
-0.015689392,
0.008581781,
-0.02208624,
0.00053595,
-0.014320518,
-0.010878592,
0.016834505,
-0.017611079,
-0.020427797,
0.017439969,
0.020664718,
-0.03014153,
0.018361326,
-0.025245178,
-0.019572252,
-0.053017505,
-0.0076077753,
0.010885173,
-0.01662391,
0.009766382,
-0.025679532,
-0.0007646439,
0.011734137,
0.010529793,
0.0064889845,
-0.0024646295,
0.032326464,
-0.03714384,
0.016360665,
-0.009193826,
0.0071273535,
-0.0074564093,
0.0049259686,
-0.0070286365,
0.0039519626,
0.036512055,
-0.014070435,
-0.01339258,
-0.009062203,
-0.007857857,
0.003425473,
0.010496887,
0.003096417,
-0.00027990327,
0.02420536,
0.040381756,
0.009450489,
-0.00012977146,
0.0020023058,
-0.016281692,
0.003206651,
0.013260958,
-0.0041329437,
-0.0007045912,
0.010779875,
-0.008160589,
-0.001627182,
0.016900318,
-0.020954287,
-0.034221824,
0.0018410684,
-0.00663706,
0.00025851463,
-0.025719019,
0.009128014,
-0.024297496,
0.015215551,
0.0068641086,
-0.025811154,
-0.03714384,
0.016781857,
-0.007818371,
0.0063409093,
-0.008739728,
-0.0018196797,
-0.016360665,
-0.008845026,
-0.011444569,
-0.01597896,
-0.015689392,
0.019690713,
-0.002685097,
-0.00910169,
-0.022810163,
0.0016674914,
-0.039749965,
-0.016136907,
-0.002461339,
0.017887484,
-0.0030207343,
0.01110235,
-0.030852292,
0.006025016,
-0.005998691,
0.031405106,
-0.024073739,
-0.015597255,
0.0152813615,
-0.028746333,
0.025113555,
0.028930604,
-0.0031408397,
-0.03372166,
0.024573904,
-0.012398831,
0.020519933,
-0.01233302,
-0.017769026,
0.043514367,
-0.018400813,
0.023771007,
0.03185262,
0.020625232,
0.016729208,
-0.017479455,
-0.011332689,
0.008963486,
-0.016571261,
-0.009851937,
-0.03219484,
-0.0026406746,
-0.016768694,
0.02473185,
-0.0005733801,
-0.038802285,
0.012451479,
0.01592631,
-0.0002724995,
-0.005590662,
-0.0011821337,
-0.0017160272,
0.0055182693,
-0.0009896359,
-0.034590367,
-0.010253386,
-0.0343008,
0.005475492,
0.0247845,
0.005274768,
-0.021230694,
0.0017818384,
-0.0034517976,
-0.023060245,
0.02149394,
-0.002755844,
-0.005923008,
-0.014728547,
0.018927302,
0.014557438,
-0.009582112,
-0.0222047,
0.00025316747,
0.0036854274,
-0.01703194,
0.00552156,
-0.017532105,
-0.025758505,
-0.009147758,
0.0032263943,
0.002337943,
-0.0104574,
-0.01926952,
-0.0058933934,
-0.025429448,
-0.005850616,
0.1831131,
-0.015899986,
0.009430746,
0.022639055,
0.0065120184,
0.01662391,
0.0011854243,
0.017295184,
-0.0015144803,
0.0016288273,
0.008779215,
-0.009601855,
-0.009851937,
-0.008594943,
-0.012089518,
0.007502477,
-0.047752608,
-0.0056005334,
0.018637734,
-0.011826273,
-0.0007181648,
-0.00267358,
0.000052854622,
-0.0040210644,
0.03319517,
-0.009963816,
-0.03024683,
0.0004026823,
0.024863472,
0.05027976,
-0.013346512,
0.017071426,
0.013517621,
0.020809503,
0.014636411,
0.0035176089,
-0.012319857,
0.0072392323,
0.014544276,
0.020625232,
0.010720645,
-0.015531444,
-0.02561372,
-0.031089213,
-0.0010036208,
0.012616008,
-0.0025699276,
0.0023017467,
0.014833845,
0.016057933,
-0.055597305,
0.010845686,
0.032273814,
0.03830212,
0.022309998,
-0.014754872,
0.0057913857,
0.0029006288,
-0.0031095794,
0.035222158,
-0.028693685,
0.016610747,
-0.010542954,
0.049569,
-0.023073409,
0.023599897,
-0.0084369965,
-0.006090827,
0.018835166,
-0.023626221,
-0.010319197,
0.021296505,
-0.021678211,
-0.021230694,
-0.012517291,
0.0041263625,
0.008838445,
0.016729208,
0.015952636,
0.009799289,
0.0016173103,
0.0006223272,
-0.03206322,
-0.0041493964,
-0.010825943,
-0.026271833,
0.021678211,
-0.0011319527,
-0.04059235,
-0.027588056,
0.0075156395,
0.003160583,
-0.012418574,
-0.012991131,
-0.0011204358,
-0.039039206,
0.0049555837,
0.0014749935,
0.010661415,
-0.01915106,
-0.011437987,
0.060704254,
-0.0076077753,
0.016492287,
-0.008088197,
-0.0048042177,
-0.01709775,
-0.005784805,
0.014188895,
-0.003288915,
0.004165849,
-0.013149078,
-0.0044883243,
-0.021480776,
-0.021217532,
0.00065482146,
0.02244162,
-0.004715373,
0.011773624,
-0.0067588105,
-0.021191208,
-0.003530771,
0.002696614,
0.012240884,
-0.0017160272,
0.020177715,
-0.0012265563,
-0.007824952,
0.010477143,
-0.031062888,
-0.0077459784,
-0.015834175,
0.002696614,
0.020546257,
0.007015474,
-0.006449498,
0.0077986275,
0.010246804,
0.009845356,
0.016373828,
-0.007910507,
-0.00090490404,
0.027061567,
-0.0055478844,
0.024336983,
-0.022770677,
0.01480752,
-0.006308004,
-0.013675568,
0.012563359,
-0.007397179,
-0.04111884,
-0.016518611,
-0.0058901026,
0.039381426,
-0.023152381,
-0.0104310755,
-0.04498854,
0.03882861,
-0.017229373,
-0.0064758225,
-0.004281019,
0.02084899,
-0.01938798,
0.006025016,
0.019519603,
-0.16405417,
0.03535378,
0.012267209,
-0.03024683,
-0.0010200737,
0.006627188,
-0.008160589,
0.008950324,
0.0018295514,
0.042171817,
0.03014153,
-0.009509719,
-0.042013872,
-0.010115182,
-0.00074119866,
-0.013346512,
-0.02044096,
0.0177427,
-0.005357032,
-0.003741367,
0.015570931,
-0.0134189045,
0.029299147,
-0.019953957,
-0.005899974,
0.022757513,
-0.003224749,
0.024126386,
-0.031589378,
-0.011563028,
0.0044389656,
0.01686083,
0.032879278,
-0.0012512355,
0.028535739,
-0.016873993,
-0.015873663,
-0.01984866,
-0.00179171,
0.023757845,
0.053359725,
0.016755532,
-0.0025978973,
0.012931901,
-0.003060221,
0.011095769,
-0.008483064,
0.009450489,
0.014228382,
-0.008410672,
0.02737746,
-0.025350476,
0.008252725,
0.032800302,
0.009930911,
0.025126718,
0.008983229,
0.005281349,
0.00036237293,
-0.0033399186,
0.00090490404,
-0.032747656,
0.025034582,
0.010542954,
0.0067127426,
-0.03224749,
-0.0033448543,
0.010259966,
-0.015215551,
0.009746639,
-0.0070944475,
-0.009404421,
0.021612398,
-0.009674246,
0.01909841,
0.03843374,
0.012951645,
-0.015570931,
0.009641341,
0.015439308,
-0.026127048,
-0.016268529,
-0.043803938,
-0.010391589,
-0.02919385,
0.009562368,
0.011595934,
0.034511395,
0.024600228,
-0.011049701,
0.024047414,
-0.008101359,
-0.015544606,
-0.039986886,
0.009384678,
0.010253386,
-0.0038631177,
-0.013379417,
0.009740058,
-0.00793025,
0.024955608,
-0.0061006984,
-0.018308677,
0.0102336425,
0.01074697,
-0.010503468,
-0.042224467,
-0.004837123,
0.020046093,
0.0037150425,
-0.01745313,
-0.014017786,
0.0046824673,
0.019769685,
-0.013412323,
0.042382415,
-0.020756854,
-0.025429448,
0.044856917,
-0.019756524,
0.044909567,
0.0023099734,
-0.000318773,
0.015610417,
-0.010003303,
-0.017400483,
-0.1324648,
-0.041724302,
0.031168185,
0.0066831275,
-0.0203225,
0.00769333,
-0.0009822322,
0.002550184,
-0.019888146,
0.026535077,
-0.007713073,
-0.0061072796,
0.026403455,
-0.0050839153,
0.031326134,
0.00358342,
0.027719678,
-0.00716684,
-0.020651555,
0.036959574,
-0.0063310377,
-0.021717697,
-0.009937491,
0.003945382,
0.008963486,
0.0158605,
-0.023784168,
0.027561732,
0.019414306,
0.007923669,
0.041224137,
-0.010621929,
0.042435065,
-0.0044323844,
-0.016465964,
-0.02642978,
-0.017466294,
-0.008035548,
0.033142522,
-0.019072087,
0.0039980304,
0.018229702,
0.012879252,
-0.006090827,
-0.0060842456,
-0.0028808855,
-0.009009554,
-0.0059657856,
0.037512384,
-0.03711752,
-0.022428459,
-0.028246168,
-0.038670663,
-0.015439308,
0.023863142,
-0.0027509083,
0.0050148135,
0.020072417,
-0.0032379113,
-0.01750578,
0.014136246,
0.005751899,
-0.0222047,
-0.012898996,
0.02995726,
0.012188235,
-0.014728547,
-0.026587727,
0.030273154,
-0.008035548,
-0.0039914493,
0.007759141,
0.0013647599,
0.0027278743,
-0.023178706,
0.0102336425,
0.00370188,
-0.01509709,
-0.025100393,
-0.0021816413,
0.00028401648,
-0.031036563,
0.021678211,
0.0031770358,
-0.0079170875,
-0.0057782237,
0.016044771,
0.007054961,
0.020717368,
-0.018453462,
-0.021362316,
0.033432093,
0.023810493,
-0.010404752,
-0.018045433,
0.027324812,
0.010523211,
-0.011247135,
0.032036893,
-0.0052089565,
-0.01074697,
-0.0085752,
-0.054070484,
-0.0077393977,
-0.004277728,
0.0013762768,
0.030115206,
-0.010529793,
0.0120763555,
-0.024429118,
0.0037446574,
-0.0049983608,
-0.021349154,
0.03024683,
-0.011892084,
-0.0054491675,
-0.018927302,
-0.03066802,
0.022191538,
-0.01409676,
0.003359662,
0.03185262,
0.0062059965,
0.0030980625,
-0.014478465,
-0.012945063,
-0.010608766,
0.017176725,
-0.03424815,
0.022283673,
-0.012398831,
-0.020756854,
0.005574209,
-0.044093505,
-0.01239225,
-0.006215868,
-0.029378122,
-0.017400483,
-0.007884182,
0.029588716,
0.016176393,
0.0058473255,
-0.010062533,
-0.019822335,
-0.0001483837,
-0.012543615,
0.0054820734,
0.004369864,
-0.018071756,
0.0011928281,
-0.015136577,
-0.004517939,
0.012852928,
0.033142522,
0.004383026,
-0.021704534,
0.011293203,
-0.000106943204,
0.0077064917,
-0.0056005334,
-0.03606454,
-0.013379417,
0.03706487,
0.004883191,
0.02120437,
-0.015057603,
-0.012155329,
-0.009720314,
-0.01879568,
0.008186914,
-0.002543603,
-0.014649574,
-0.012260627,
-0.010937822,
0.01609742,
0.017545266,
0.021717697,
-0.010510049,
-0.030510074,
-0.011780205,
-0.010062533,
0.030115206,
0.028061897,
0.00364265,
-0.03072067,
0.019822335,
0.03153673,
0.010055952,
-0.0015893405,
-0.00710761,
0.0027739422,
0.016584422,
0.0067127426,
0.003988159,
0.010891754,
0.014057273,
0.007824952,
0.020756854,
-0.012260627,
-0.013083267,
-0.005034557,
0.0122935325,
-0.0039388007,
0.00085307774,
0.0052287,
-0.01920371,
-0.011892084,
0.007719654,
-0.03319517,
-0.045567676,
-0.0028117837,
-0.013965137,
0.0056433105,
-0.0035702577,
0.011819692,
0.0028743043,
-0.021191208,
-0.0063409093,
-0.011576191,
0.018216541,
-0.023599897,
0.022257349,
0.012326438,
0.011839435,
-0.000060618288,
-0.0042020455,
-0.0015391596,
-0.007943412,
0.036038216,
-0.01392565,
0.034327123,
-0.0012026997,
0.0064659505,
0.0032214583,
-0.026666699,
-0.026469266,
-0.005511688,
-0.009851937,
-0.014689061,
0.0053339982,
-0.02895693,
0.078025766,
0.0014898011,
-0.0003858182,
0.0052319905,
0.0030947719,
0.025640044,
-0.0057420274,
0.021480776,
-0.022836488,
-0.0054491675,
0.012267209,
-0.007831533,
0.02673251,
-0.059651274,
-0.023165543,
0.02137548,
-0.00793025,
-0.021599237,
0.009904586,
-0.00352419,
-0.0014437332,
-0.012977969,
-0.028351467,
-0.008535713,
-0.040618673,
0.020072417,
0.029035904,
0.01709775,
0.017650565,
-0.028351467,
0.001377922,
0.004837123,
-0.04669963,
-0.00032535414,
0.00604805,
-0.00027496743,
-0.025547909,
-0.036275133,
0.008996392,
0.015649904,
-0.0033859864,
0.022981273,
-0.0253768,
0.0022573243,
0.00017193177,
-0.02055942,
-0.017966459,
0.008548875,
-0.00963476
] |
Apoptosis is a frequent phenomenon in breast cancer and it can be detected by light microscopy in conventional histopathological sections or by special staining techniques. The number of apoptotic cells as a percentage of cells present, or the number of apoptotic cells per square millimetre of neoplastic tissue, is usually described as the apoptotic index (AI). In breast cancer, the AI is not related to tumour size, axillary lymph node metastasis or distant metastasis at diagnosis. It is greater in invasive ductal carcinomas than in other histological types. High AI is also related to high histological grade, high nuclear | [
-0.032982174,
-0.0023827052,
-0.0059748883,
-0.007513925,
-0.018613443,
0.000991146,
-0.01882436,
0.013142778,
-0.0023069067,
-0.0010422275,
0.021447642,
0.0049598496,
-0.00048362653,
0.014909209,
-0.016095618,
0.011607037,
0.043211658,
0.018573895,
0.003092903,
-0.016517453,
-0.044846267,
0.03517044,
-0.01480375,
-0.00021441875,
0.004491877,
0.01832343,
-0.00061956927,
-0.041366134,
0.008627831,
-0.014276457,
0.019074824,
0.012905495,
-0.012806628,
0.0008519077,
-0.007480969,
0.017084293,
0.014302822,
0.00069495564,
0.016741551,
0.0034900203,
-0.0035921833,
0.0029808532,
-0.009478091,
0.011943186,
-0.02121036,
0.014856479,
-0.0028589165,
-0.0013989742,
-0.0009071087,
0.012233197,
0.00964287,
0.01446101,
-0.01741385,
-0.017427033,
0.005632148,
0.009352859,
0.003256034,
0.026048273,
0.012819811,
0.008278499,
0.0029067025,
-0.01593743,
-0.023675455,
0.014935574,
-0.0015761117,
0.008397141,
0.0039546974,
0.024980504,
0.016240623,
0.0026562384,
0.03459042,
0.040021535,
-0.018165244,
-0.00198394,
0.026456924,
0.0042348215,
-0.015739696,
-0.012734125,
-0.012655031,
0.0006537609,
0.0088453395,
-0.014355551,
0.027129224,
0.009227627,
0.020076679,
0.016438358,
-0.023939101,
0.0137228,
0.00245356,
-0.0075271074,
0.010822688,
0.006630709,
0.010453583,
0.014105087,
-0.015080579,
0.015304678,
-0.0016494383,
0.019048458,
0.015831972,
-0.033113997,
0.0024255477,
0.0075798365,
-0.0030302869,
-0.01298459,
-0.0015942374,
-0.008805793,
0.026720572,
0.01571333,
0.015621054,
-0.0011394472,
0.0004807429,
0.039836984,
0.008331229,
-0.040759746,
0.050910138,
-0.008720107,
0.014961938,
-0.008608058,
-0.026008725,
-0.0016197781,
0.006732872,
0.011989324,
0.042447083,
-0.011363164,
0.0058101094,
0.010967694,
-0.012206832,
-0.005490438,
-0.026694207,
-0.009023301,
0.03256034,
0.009306721,
0.02581099,
0.008614649,
0.001982292,
-0.011382937,
-0.014329187,
0.00033553134,
-0.020656703,
-0.042104345,
0.016411994,
0.026931489,
0.001761488,
-0.003043469,
-0.01741385,
0.02847382,
0.016174711,
0.0071777757,
-0.01990531,
0.011092926,
-0.011092926,
-0.01355143,
-0.0054080486,
-0.010440401,
0.0018175129,
-0.009497865,
0.022937244,
0.012687987,
-0.041155215,
-0.013854623,
-0.0031060851,
0.010387671,
0.002690842,
0.021750836,
0.033509467,
0.0241632,
-0.0054245265,
0.009761511,
-0.007757798,
-0.03793873,
0.00856851,
0.0013701378,
-0.021329,
0.021065354,
-0.000018743618,
-0.00029619035,
0.0012045349,
0.021025807,
-0.030372076,
-0.01406554,
-0.013300966,
0.022462681,
0.0034241087,
-0.016082436,
-0.012569346,
0.013525065,
0.020406239,
-0.012226606,
-0.004979623,
-0.014368733,
-0.0048478,
0.025138693,
-0.009530821,
-0.012806628,
-0.6458284,
-0.030372076,
0.007850074,
-0.00055489346,
0.030503899,
0.031294838,
0.022027664,
-0.0156606,
-0.001093309,
-0.018481618,
-0.028341997,
0.011758633,
-0.009682417,
-0.00028280204,
0.008601466,
-0.038360562,
-0.013393242,
-0.005553054,
0.015041032,
-0.0024749814,
-0.0062154657,
-0.0012564403,
-0.024360936,
0.015159673,
-0.02098626,
0.02041942,
0.027682882,
-0.0124177495,
0.0041095894,
0.031611215,
-0.020893984,
0.023345897,
-0.010796323,
0.011943186,
0.052492015,
-0.0048873466,
0.006475817,
0.02813108,
0.032243967,
0.038413294,
-0.005075195,
-0.0069998144,
0.00720414,
-0.012404568,
-0.014790568,
0.0073491456,
0.008891478,
-0.00918808,
0.016240623,
-0.015159673,
0.008917842,
0.020973079,
-0.039652433,
0.0017120544,
0.0024403778,
0.007329372,
0.01150817,
-0.014250092,
0.015410137,
-0.0076259747,
0.033588562,
-0.008021444,
-0.013070274,
-0.0054080486,
-0.029475678,
0.012463887,
-0.015621054,
-0.003618548,
-0.012015688,
-0.010044931,
0.0077446154,
0.024624582,
0.00490712,
0.0016000046,
0.023504084,
0.023715,
0.0031258587,
0.02035351,
-0.01338665,
0.0000684863,
0.009016709,
-0.014843297,
-0.027946528,
0.004030496,
-0.00097466813,
-0.00015231763,
0.0063901315,
0.0024749814,
0.008865113,
0.0049203024,
0.008265317,
0.001266327,
-0.00039155624,
-0.033667658,
-0.009932881,
0.015317861,
-0.007995079,
0.011679539,
0.00873329,
-0.0357241,
-0.026984219,
-0.0009796115,
-0.003658095,
0.026219644,
0.029027479,
0.011514761,
-0.031004827,
-0.008324638,
0.017598404,
-0.034353137,
-0.004956554,
0.00714482,
0.015186038,
-0.0060671647,
0.013083457,
-0.010414036,
0.014025993,
0.03163758,
-0.00086014665,
-0.01343938,
0.03174304,
0.002847382,
0.013696435,
-0.014961938,
0.033825845,
-0.013485517,
0.001675803,
-0.01287913,
-0.0018356387,
-0.0145005565,
0.001612363,
-0.04365986,
-0.005417935,
-0.008034627,
0.00082801474,
-0.02234404,
-0.010750186,
-0.007810527,
-0.002619987,
-0.021474006,
-0.016912922,
0.012088192,
0.0300557,
-0.01287913,
-0.008430096,
-0.016148347,
-0.020076679,
0.01950984,
0.013986446,
0.015752878,
-0.017150205,
0.010954511,
0.019588934,
0.009326494,
0.024176383,
0.011363164,
-0.014474192,
-0.009273766,
0.0057046507,
0.0056255567,
-0.008858522,
0.036567766,
0.008291682,
-0.014039176,
-0.0187189,
-0.017387485,
0.0023069067,
0.016464723,
-0.000314522,
-0.03374675,
-0.005480551,
-0.0031373932,
-0.022106757,
0.010414036,
0.008528964,
-0.014553286,
-0.02325362,
-0.012628667,
0.0011831137,
-0.0103349425,
0.018850723,
-0.010117434,
-0.00017528371,
0.015054215,
0.025547344,
0.039283328,
0.033034906,
-0.0036317303,
-0.0028177218,
0.016715188,
-0.012187059,
0.022673598,
-0.0046599517,
0.008436687,
-0.0050554215,
-0.008535555,
0.0064263833,
0.018283883,
0.012404568,
0.036383215,
0.03664686,
0.00019124668,
0.03970516,
0.010526086,
0.02552098,
-0.005734311,
-0.0076852953,
-0.008812384,
0.01899573,
0.0057672667,
0.017123839,
0.016912922,
-0.011956369,
-0.0035526364,
-0.007329372,
0.00076086726,
0.022937244,
-0.010216301,
-0.0025540753,
-0.009049665,
-0.007995079,
0.011349982,
0.017123839,
-0.00612319,
0.011712495,
0.0023332713,
0.05051467,
0.023556814,
-0.0072634607,
-0.008832158,
0.002053147,
0.026694207,
-0.012002506,
0.012819811,
0.026127366,
0.016003342,
0.019892128,
0.023886371,
0.012305699,
-0.0070920903,
-0.007065726,
0.0155419605,
0.0015868223,
-0.002463447,
0.019707575,
0.004429261,
0.019668028,
0.024255477,
-0.012154103,
-0.013999629,
0.014487375,
-0.008786019,
-0.013604159,
0.022264946,
0.0005207018,
-0.012028871,
0.010862235,
0.0137491645,
0.021183996,
0.006413201,
0.029844781,
-0.023187708,
0.0038426477,
0.002847382,
-0.012720943,
-0.0065021813,
0.017572038,
0.0061627366,
0.00879261,
-0.008238953,
-0.02857928,
-0.0032296695,
0.034537688,
-0.027261047,
0.032876715,
-0.0106381355,
0.017440215,
0.025112327,
0.008219179,
0.0005697236,
-0.019417563,
-0.047561824,
0.02739287,
0.018600259,
0.005595897,
-0.0024519123,
-0.0075336983,
-0.011541125,
-0.022897698,
0.010269031,
0.0026298738,
0.025639622,
-0.008614649,
0.010849053,
-0.017440215,
-0.0038195786,
0.00023542807,
-0.004617109,
0.020182138,
-0.0134987,
0.02229131,
-0.019417563,
-0.0050224657,
-0.0014574707,
0.024769587,
-0.003470247,
-0.0034175175,
-0.0017730226,
-0.028262904,
-0.016425176,
-0.032296695,
-0.02857928,
0.0069273114,
-0.0068416265,
0.010400854,
-0.0022492341,
0.014157817,
0.0025507798,
0.016992016,
0.016596546,
0.004379827,
-0.00839055,
0.007039361,
-0.014935574,
0.02705013,
0.029554771,
-0.012160694,
0.007731433,
-0.000021807478,
0.012206832,
0.012028871,
0.002872099,
0.016992016,
0.006284673,
-0.014025993,
-0.000014289433,
0.018863905,
0.013050501,
0.03772781,
0.022568138,
0.014830115,
-0.016912922,
-0.025099145,
-0.02041942,
-0.01338665,
-0.02557371,
0.033614926,
0.019101188,
0.011501578,
-0.0069207205,
0.022647234,
-0.0027270934,
0.0071052727,
-0.01882436,
-0.0020564427,
0.03000297,
0.00890466,
0.020393055,
-0.0033268891,
-0.01616153,
0.022699963,
-0.00094583177,
-0.016016524,
-0.029449312,
-0.0050620125,
0.030925732,
0.005279521,
-0.004336985,
0.008351003,
-0.0067460546,
0.02490141,
0.01763795,
-0.015265131,
-0.010394263,
0.020775342,
-0.006535137,
-0.021526735,
-0.02631192,
-0.0011377994,
0.011692721,
-0.0037668492,
-0.009781284,
0.015212403,
-0.020485332,
-0.010137208,
-0.010704047,
-0.0056255567,
-0.0056255567,
-0.019430745,
-0.017717045,
-0.022502227,
-0.015568325,
-0.015238767,
-0.023121797,
0.020748978,
-0.028236538,
-0.02625919,
-0.0079621235,
0.0070789084,
0.016794281,
-0.0028671555,
-0.022884514,
-0.018732082,
0.03733234,
-0.00907603,
0.008871704,
-0.0038953768,
-0.033667658,
0.0058265873,
-0.00788303,
-0.028289268,
-0.019918492,
-0.028737467,
0.0057936315,
-0.0038887856,
-0.021592647,
0.022449499,
0.006090234,
-0.022660416,
0.0028704512,
0.01293186,
0.014368733,
-0.01196296,
-0.011185202,
0.010203119,
-0.030213887,
-0.033087634,
-0.014790568,
-0.020458966,
-0.028763833,
-0.0073359637,
0.011251113,
-0.0056189657,
0.0022212216,
-0.012720943,
-0.013063683,
0.015700148,
-0.0011476862,
0.0042743688,
0.038439658,
0.0033483105,
0.003139041,
0.027498329,
0.017796138,
0.014184181,
-0.008720107,
0.011448849,
0.020234868,
0.0023513972,
-0.007118455,
-0.034326773,
-0.0011163781,
-0.014091904,
-0.002674364,
-0.010051522,
-0.008232362,
0.0054443,
-0.037701447,
-0.008245544,
-0.021065354,
0.0010867178,
0.0026381128,
0.013393242,
-0.029317489,
-0.00674935,
0.009181489,
-0.007902804,
-0.018389342,
0.014118269,
-0.03430041,
-0.009497865,
0.027630152,
-0.0010446992,
0.00533225,
-0.005127924,
-0.00558601,
-0.012015688,
-0.0072964164,
-0.01662291,
-0.021197177,
0.005892499,
-0.0012918678,
0.023780912,
0.0125627555,
0.031795766,
0.021104902,
0.034669515,
0.021935388,
-0.006835035,
0.01587152,
0.009946064,
0.01786205,
-0.004679725,
0.026615113,
0.013604159,
0.0026727163,
0.021553101,
0.00036148404,
0.024545487,
0.020683067,
-0.005312477,
-0.042921647,
-0.008535555,
-0.031558484,
-0.032692164,
-0.0022904288,
-0.0006269843,
0.018165244,
-0.034063127,
0.017427033,
0.026048273,
0.016939286,
0.0045907446,
-0.005516803,
0.027893798,
-0.01667564,
0.009682417,
0.007981897,
-0.016807463,
-0.018442072,
-0.01355143,
0.004973032,
-0.007309599,
0.025217786,
-0.009768102,
0.018125696,
0.008232362,
-0.040970664,
0.018969364,
-0.01571333,
-0.029554771,
-0.019668028,
-0.01684701,
-0.010809506,
-0.024453212,
-0.025876902,
-0.015317861,
-0.03227033,
0.014922391,
0.024940958,
0.002555723,
0.025151875,
0.0042282306,
-0.023042703,
0.023293167,
0.00081153685,
0.009135351,
-0.029686594,
0.040522464,
-0.0009161715,
-0.016187895,
-0.027603786,
0.00021853822,
-0.012846175,
0.022330858,
0.019180281,
0.01355143,
-0.020155774,
-0.002067977,
0.0037108243,
0.014658744,
-0.0037569625,
-0.022568138,
0.03316673,
0.010156981,
0.008416914,
-0.022884514,
-0.009484682,
-0.05009283,
0.009082622,
-0.006291264,
-0.010585407,
0.014882844,
-0.011574081,
0.0009021653,
0.008614649,
-0.006561502,
0.004752228,
-0.0038953768,
-0.009122169,
-0.021500371,
-0.021421278,
-0.010071295,
0.015911065,
-0.005421231,
0.02229131,
-0.014355551,
-0.0048445044,
0.01684701,
-0.0023876484,
-0.0041326587,
-0.009016709,
-0.0006208051,
0.03669959,
0.0010199824,
-0.0072634607,
-0.0038426477,
0.011165429,
0.0079555325,
-0.02581099,
-0.0076062013,
0.004893938,
-0.021500371,
-0.004804957,
0.013116413,
0.024677312,
-0.007362328,
-0.014329187,
-0.036910508,
0.00839055,
-0.015106943,
-0.01049313,
0.017664315,
-0.027524693,
-0.022423133,
0.008502599,
0.0023299758,
0.002407422,
0.04039064,
0.0010867178,
-0.019035276,
0.038492385,
-0.005523394,
0.0085487375,
0.009761511,
0.004215048,
-0.0007291473,
0.014276457,
-0.006175919,
-0.010420627,
0.0050191698,
-0.011125882,
-0.023069067,
-0.0153969545,
-0.008351003,
0.012813219,
0.014698291,
-0.012167285,
-0.004152432,
0.011784998,
-0.00470609,
-0.005200427,
-0.007803936,
0.024018195,
-0.028183809,
0.021684924,
0.021131266,
-0.0020251346,
-0.031004827,
-0.024176383,
-0.0037009376,
0.0026232826,
-0.015568325,
-0.025784627,
-0.006498886,
0.035407722,
-0.0013239997,
-0.009273766,
-0.019457111,
0.020168956,
-0.035117712,
0.011639993,
-0.00007327519,
-0.00013264714,
-0.0010875418,
-0.00053923944,
-0.01480375,
0.012839584,
-0.018639807,
-0.005269634,
0.0021602535,
-0.03601411,
-0.015462866,
0.007652339,
-0.043475304,
0.01559469,
0.019562569,
-0.011653175,
-0.024519123,
-0.013709617,
-0.032507613,
-0.01111929,
-0.01196296,
0.0045907446,
-0.017374303,
0.023174526,
-0.010756777,
-0.0049400763,
0.002903407,
-0.002555723,
-0.018692536,
-0.027155587,
0.002234404,
0.006634005,
0.009346268,
-0.029159302,
-0.013004363,
-0.03324582,
0.007902804,
-0.020973079,
-0.021276271,
0.00703277,
-0.003783327,
0.011290661,
-0.011481805,
0.0027897095,
-0.0022294605,
0.029053843,
0.010763368,
-0.016451541,
0.003987653,
0.003994244,
0.010882009,
-0.012325473,
0.016517453,
-0.015014667,
0.039230596,
-0.0049038245,
-0.017255662,
-0.02189584,
0.001416276,
-0.018850723,
0.01724248,
0.019470293,
-0.006106712,
0.035381358,
0.0076589305,
-0.0059979577,
-0.0046500647,
-0.021118084,
-0.04236799,
-0.016583364,
0.001566225,
-0.02047215,
-0.016398812,
-0.0021981525,
0.036541402,
-0.025178239,
0.0005301766,
-0.0025145283,
-0.010987467,
-0.025890086,
0.02540234,
0.017690679,
0.0034867248,
-0.01020971,
0.0137228,
-0.01514649,
-0.023952283,
-0.0015736399,
-0.00044737512,
-0.02705013,
0.005223496,
-0.012055236,
-0.009873561,
0.011481805,
-0.006512068,
-0.01979985,
-0.026984219,
0.018850723,
0.17242481,
-0.023886371,
-0.012523208,
0.0122727435,
-0.014869662,
-0.0161088,
0.01224638,
-0.0019262672,
-0.0021338887,
0.026891941,
0.015990159,
0.0013899113,
-0.024980504,
0.0054871426,
0.028262904,
-0.012503435,
-0.014250092,
-0.011560898,
0.0058957944,
0.0071316375,
0.007408466,
-0.016583364,
0.016636094,
0.024914593,
0.026957853,
0.00031493398,
-0.021698106,
0.0053849793,
0.022172669,
-0.0075271074,
-0.009201262,
-0.0034966115,
-0.0068614,
-0.010117434,
-0.014513739,
-0.009267174,
-0.02966023,
-0.011877274,
0.02189584,
-0.015304678,
0.0056782863,
-0.0023810572,
-0.0070064054,
0.0063374024,
-0.009932881,
0.004145841,
-0.0023250324,
-0.025217786,
0.001911437,
-0.007560063,
-0.02167174,
0.0037108243,
0.0017944439,
-0.0008642661,
-0.0017351235,
0.007948942,
0.00041647904,
-0.008298273,
-0.008753063,
0.016003342,
-0.011679539,
0.008469643,
-0.041260675,
0.028157445,
-0.017901596,
0.012905495,
-0.029792054,
-0.0070261788,
0.006142963,
-0.0038986725,
0.013050501,
-0.0027732316,
-0.038202375,
-0.0021355366,
0.007560063,
-0.021474006,
0.00530259,
0.029422948,
-0.0022080394,
-0.0016486144,
0.018112514,
0.002697433,
-0.014170999,
0.018468436,
-0.02404456,
-0.024189565,
0.011600445,
0.009959246,
0.0055991923,
-0.024743224,
-0.005483847,
-0.014039176,
0.005068604,
0.004636883,
0.0352759,
0.009504456,
0.014184181,
0.014592833,
-0.023345897,
0.0019410972,
-0.014105087,
0.06084961,
0.011040197,
0.004383123,
0.0023085545,
-0.004541311,
-0.028447457,
0.013426198,
0.0075007426,
-0.005127924,
0.0220013,
-0.028368361,
-0.004864278,
-0.015686966,
-0.003343367,
0.019984404,
-0.003799805,
-0.023649089,
0.009049665,
-0.014210545,
-0.022185853,
-0.03799146,
0.033509467,
0.008186223,
-0.018138878,
-0.0014088609,
-0.048010025,
0.009557185,
-0.006050687,
-0.017308392,
0.013880988,
-0.0055398718,
-0.017651131,
0.03590865,
0.0073689194,
-0.0058661345,
-0.014764204,
-0.02529688,
-0.011936595,
0.022634052,
-0.016688822,
0.014685109,
-0.02433457,
-0.010552451,
0.011982732,
0.0011254409,
0.029449312,
0.020999443,
-0.030424805,
-0.03216487,
-0.0098867435,
-0.0064791124,
-0.029106572,
-0.007401875,
0.036066838,
-0.015357408,
-0.008654196,
-0.0017664315,
-0.00041091777,
0.004458921,
-0.023359079,
0.011435666,
0.013123004,
0.0044193743,
-0.013175733,
-0.001251497,
-0.16493724,
0.010203119,
0.036066838,
-0.01264844,
0.030240253,
0.008265317,
-0.016926104,
-0.005253156,
0.018521165,
-0.00313245,
0.017492944,
-0.0064263833,
-0.012793446,
-0.0032395562,
0.0002611748,
-0.009036483,
0.038307834,
0.04774638,
0.022106757,
0.00030957864,
-0.0011040197,
-0.002619987,
0.042394355,
0.009616505,
-0.00024160728,
0.00833782,
-0.002242643,
0.00044490345,
0.014751021,
-0.0071777757,
-0.0060144356,
-0.014764204,
-0.0007369743,
-0.008561919,
0.036541402,
-0.0073227813,
-0.023780912,
-0.008805793,
-0.014764204,
0.0058463607,
0.01950984,
0.02842109,
-0.011264296,
-0.018877089,
-0.012101374,
0.021711288,
0.0063275155,
-0.0006994871,
0.01968121,
-0.0011196737,
0.02778834,
-0.016359264,
-0.0026644773,
0.006554911,
-0.016912922,
0.02115763,
0.023846826,
0.007329372,
0.024229113,
0.00519054,
0.0018142174,
-0.01780932,
0.025389157,
0.014553286,
-0.0029610796,
-0.032982174,
-0.02643056,
0.031795766,
-0.026971035,
-0.0062747863,
-0.0043600537,
-0.0042545954,
0.025336428,
-0.03901968,
0.026601931,
0.0019361539,
0.0006867167,
0.008884886,
0.007158002,
0.020564426,
-0.021131266,
0.023543632,
-0.029871147,
-0.017519308,
-0.006739463,
-0.003948106,
0.029686594,
0.0050949682,
-0.02223858,
-0.0039777663,
0.024505941,
-0.028289268,
0.013182324,
-0.011290661,
0.0040008356,
0.043475304,
-0.009853788,
-0.02148719,
-0.0031917703,
-0.0028391432,
-0.0054475954,
-0.0050554215,
-0.008575102,
0.012872539,
0.012556164,
0.012068418,
-0.026509654,
-0.017769773,
0.05069922,
-0.02024805,
-0.027867433,
-0.023504084,
-0.01480375,
-0.004541311,
-0.010394263,
0.04468808,
0.022159487,
0.0014879549,
0.0075864275,
-0.018138878,
0.073662825,
-0.0064857034,
-0.0029940354,
0.0127143515,
0.014935574,
-0.029212032,
-0.13846713,
-0.016939286,
0.012094783,
0.028632008,
-0.0072502783,
0.009965837,
-0.015647419,
0.021342183,
-0.028210174,
0.030503899,
-0.017730227,
-0.008304864,
-0.035776827,
-0.0013948547,
0.020221686,
-0.0006273962,
-0.0046204044,
-0.014737839,
-0.004953258,
0.02382046,
-0.00095324684,
0.016240623,
0.014395098,
-0.0051971315,
0.005609079,
-0.03532863,
-0.024809135,
0.026522836,
0.0009375928,
0.0093001295,
0.0068745823,
-0.014118269,
0.0022937243,
-0.0017301801,
-0.012892313,
-0.0022245173,
-0.008443278,
-0.024545487,
0.034247678,
-0.014170999,
-0.011336799,
0.016148347,
0.025151875,
0.0027270934,
0.005945228,
-0.025771445,
-0.012536391,
0.001305874,
0.00025684934,
-0.017387485,
-0.00092852995,
-0.016939286,
-0.016266989,
0.011494987,
0.0031901225,
-0.022462681,
0.04128704,
0.006647187,
-0.011831136,
0.003931628,
0.0057474934,
0.005068604,
0.0011394472,
0.026681025,
0.04439807,
-0.01944393,
-0.023293167,
-0.01247707,
0.0075534717,
0.0045808577,
0.015568325,
0.0036449127,
-0.014434645,
-0.0121211475,
-0.030029334,
-0.019588934,
-0.01672837,
0.006192397,
0.010618363,
-0.014896027,
-0.013419606,
-0.01514649,
-0.0017927961,
0.01219365,
0.023029521,
-0.003941515,
-0.00088156795,
-0.011099517,
0.015172855,
-0.026641477,
0.004363349,
0.045979947,
0.015370591,
-0.03364129,
-0.017018382,
0.0010611771,
0.010677682,
-0.0016716835,
0.01315596,
0.015001485,
-0.02325362,
-0.016741551,
-0.039652433,
0.011831136,
-0.016583364,
0.016992016,
0.009847196,
-0.015528778,
-0.0068218526,
-0.015436502,
0.005404753,
0.032823987,
-0.0074941516,
0.028632008,
-0.009089213,
-0.001644495,
-0.00731619,
-0.007915986,
0.003264273,
-0.0043501672,
-0.0016922809,
0.023293167,
0.0014665336,
-0.0056881728,
0.012345247,
-0.024624582,
0.0056354436,
-0.008739881,
0.0017631359,
0.023148162,
-0.0055991923,
0.0032823987,
0.0335622,
-0.04202525,
-0.024400482,
-0.0054937336,
-0.035539545,
-0.023069067,
-0.006301151,
0.02500687,
0.027234683,
0.022634052,
-0.024268659,
-0.022871332,
0.025679167,
-0.0016725074,
-0.018732082,
-0.012655031,
-0.026496472,
-0.0008164802,
0.0068811732,
-0.013933716,
0.050224654,
-0.004046974,
-0.0074546044,
-0.03675232,
-0.032296695,
-0.012450705,
-0.007045952,
-0.02540234,
-0.021025807,
0.0013091696,
0.018956183,
0.012707761,
0.0008667378,
0.013076866,
-0.0053157723,
-0.009352859,
-0.03917787,
0.013604159,
-0.007942351,
-0.0217772,
-0.012595711,
-0.020406239,
0.0031818836,
0.0053289547,
0.02552098,
0.019483475,
-0.009115578,
-0.0054772557,
0.008522373,
0.01746658,
0.0067954883,
0.006914129,
-0.023715,
0.022449499,
0.036778685,
0.00087827235,
-0.024479575,
0.043923505,
0.0051806537,
-0.0039777663,
0.0008519077,
0.02734014,
0.016293352,
0.0072964164,
-0.009326494,
-0.0046138135,
-0.00856851,
0.011218158,
-0.0071711843,
0.023293167,
-0.011013832,
0.008680561,
0.0012160694,
-0.005263043,
-0.028078351,
0.021526735,
-0.020722615,
-0.030925732,
-0.009398997,
-0.0031967137,
0.022040846,
0.011554307,
0.017572038,
0.0055893054,
-0.011158838,
0.032639436,
0.0063110376,
-0.0018175129,
-0.021843111,
0.037780542,
0.0055563496,
0.018507984,
0.013485517,
-0.0028177218,
0.02495414,
0.0026381128,
0.016240623,
-0.03675232,
0.024084106,
-0.014658744,
0.029106572,
-0.013656888,
-0.0671244,
0.0012811571,
-0.0023612839,
-0.019180281,
0.022159487,
0.017572038,
-0.012173876,
0.06860082,
0.010315169,
-0.02291088,
0.011033606,
-0.013182324,
0.015858335,
0.010064704,
-0.0032873421,
-0.004129363,
-0.026496472,
0.0040403823,
-0.010769959,
0.01571333,
-0.031163014,
-0.03153212,
0.017110657,
-0.023490902,
0.0017532491,
0.015106943,
-0.032876715,
0.004933485,
0.0043468713,
0.0009845549,
0.019430745,
-0.022159487,
0.017150205,
0.00986697,
-0.0028111306,
0.005342137,
-0.008285091,
-0.0056881728,
-0.033483103,
-0.04128704,
-0.016135165,
0.023728184,
-0.020155774,
-0.0059847753,
-0.048010025,
-0.013907352,
0.026681025,
-0.002926476,
0.008713516,
-0.015568325,
-0.035750464,
-0.031373933,
0.018402524,
-0.02301634,
-0.023794096,
-0.0113763455
] |
Flavonoids comprise the most common group of plant polyphenols and provide much of the flavor and color to fruits and vegetables. More than 5000 different flavonoids have been described. The six major subclasses of flavonoids include the flavones (e.g., apigenin, luteolin), flavonols (e.g., quercetin, myricetin), flavanones (e.g., naringenin, hesperidin), catechins or flavanols (e.g., epicatechin, gallocatechin), anthocyanidins (e.g., cyanid | [
0.008036092,
0.0063747843,
-0.017050939,
-0.025718069,
-0.0013401535,
0.025254449,
-0.005125584,
-0.004542839,
-0.019162988,
0.0015510365,
-0.007688376,
0.01907284,
-0.04103043,
0.018325895,
-0.036239684,
0.025009759,
0.04440456,
0.012305265,
0.0017514558,
0.013155237,
-0.021390943,
0.037939623,
0.0038409685,
-0.0027157224,
0.0038023335,
0.043271262,
0.026632432,
-0.04538331,
-0.0015969157,
0.01039283,
0.0050933883,
0.011777253,
-0.005421786,
-0.017540315,
0.006120437,
-0.0009940477,
0.0031841726,
-0.011925354,
0.0021233184,
0.013457878,
0.021455334,
0.0048937737,
0.0054636407,
-0.013715445,
-0.017836517,
-0.004800406,
-0.011983306,
0.007797842,
-0.021378065,
0.037630543,
0.009877696,
0.0029909972,
0.019652365,
-0.013857107,
0.008583422,
-0.021133376,
0.004188684,
0.0064423955,
-0.008113362,
-0.024546139,
0.0065840576,
0.021609874,
-0.0159434,
0.006703182,
-0.015273726,
0.012363218,
0.00082582433,
-0.0036993066,
-0.028152077,
0.0053509553,
0.014552537,
0.0461045,
-0.019034205,
0.000320349,
0.014745713,
-0.024314329,
-0.044687882,
0.007881551,
-0.01773349,
-0.010779181,
0.0036220364,
-0.005209293,
-0.015389631,
0.017231235,
0.027405133,
0.012021941,
-0.012279509,
0.027559673,
0.014410876,
-0.012678738,
-0.0046233283,
0.008776597,
0.028744482,
0.006165511,
-0.022524238,
0.011435976,
-0.0027801143,
0.01367681,
0.002218296,
-0.014616929,
-0.0010037066,
0.017553193,
-0.005499056,
-0.0017900909,
-0.024365842,
0.0010930501,
0.009858378,
0.0013755689,
0.018029694,
0.0021297575,
-0.014668443,
0.019021327,
0.0057212077,
-0.054758754,
-0.0039729713,
-0.020888686,
0.024984002,
0.0053799315,
-0.018634975,
-0.019884175,
-0.006728939,
0.02000008,
0.02977475,
-0.01656156,
0.039253216,
-0.014616929,
0.024365842,
-0.020811416,
-0.015093428,
0.00036280733,
0.025486259,
0.027842997,
0.010032237,
0.0035673035,
-0.011893158,
0.019961445,
-0.035054874,
-0.011043186,
0.0007203828,
0.013148798,
0.013741202,
0.027199078,
0.0018432142,
0.009433392,
0.002617525,
0.020231891,
0.028152077,
0.035956357,
0.0071539246,
-0.0019736073,
0.019008446,
0.004916311,
0.034179147,
-0.012756008,
0.013213189,
0.0049098716,
0.0039053601,
0.014552537,
-0.026155932,
0.020206135,
0.024777949,
-0.02311664,
0.008029653,
-0.020515215,
-0.0010616592,
0.009330366,
0.040669836,
-0.005521593,
-0.013200311,
0.024855219,
0.0010616592,
0.014887375,
0.012144286,
0.023155278,
0.0171926,
0.013052209,
0.014732835,
-0.006909236,
-0.0068899184,
-0.015183577,
0.004414055,
0.006838405,
0.0043174676,
-0.021777293,
-0.015350996,
0.006461713,
0.020515215,
0.017514559,
-0.003390226,
-0.016767614,
-0.026812728,
0.01836453,
0.0014230579,
-0.02024477,
-0.6362936,
-0.026143054,
0.040283486,
-0.02352875,
0.020193256,
0.025357476,
0.008989089,
0.007643302,
-0.013766958,
-0.0068126484,
0.0029797286,
0.005837113,
0.027636943,
0.014101795,
0.0032067096,
-0.035982113,
0.011120457,
-0.04072135,
-0.010070872,
0.006226683,
-0.033638254,
0.020347796,
-0.010586006,
0.0019253136,
0.004929189,
0.023425722,
0.011229923,
-0.009581494,
-0.0119189145,
0.006658108,
-0.027714213,
0.008036092,
0.008010335,
0.03726995,
0.043193992,
0.022408333,
-0.016703222,
0.019755391,
0.03132015,
0.039588053,
-0.014784348,
0.010837133,
0.024404477,
-0.022949222,
-0.015041915,
0.017553193,
0.015531292,
0.02203486,
-0.010457221,
0.0051899757,
0.020566728,
-0.0019269234,
-0.00033705062,
-0.008506152,
0.009587933,
0.00882811,
0.041777372,
-0.010231851,
-0.0121957995,
0.039510783,
-0.013213189,
0.0018544827,
-0.032917067,
-0.019330407,
-0.025421867,
0.028718725,
-0.02735362,
0.015492657,
0.011294315,
-0.023721924,
0.024404477,
0.02374768,
-0.0073599783,
-0.044353046,
0.051281597,
-0.013168115,
0.016767614,
-0.006493909,
-0.021931833,
0.025460502,
0.0026062564,
-0.016445655,
-0.027121808,
0.010804937,
0.028976291,
0.0053509553,
0.003966532,
-0.00906636,
0.0078107202,
-0.015879007,
0.020695511,
0.0069800667,
-0.0063876626,
-0.026027149,
-0.02397949,
0.014681322,
-0.022421211,
-0.024108274,
-0.019703878,
-0.028744482,
-0.010714789,
-0.035570007,
-0.017128209,
0.019317528,
0.026477892,
0.0115712,
-0.012820399,
0.014449511,
0.030418668,
-0.024095396,
0.0019092157,
-0.00066404004,
-0.014758592,
0.014320727,
-0.007797842,
-0.015441144,
0.02476507,
0.015054793,
-0.013651053,
-0.015376752,
0.019330407,
0.02009023,
-0.04157132,
0.017141087,
0.021275038,
0.034333687,
-0.013689688,
-0.015557049,
-0.013264703,
-0.023850707,
0.043425802,
0.012846156,
0.02212501,
0.024726436,
0.008641374,
-0.002828408,
0.019098597,
-0.0029797286,
0.0075724707,
-0.016728979,
0.0007417126,
-0.013110163,
-0.0016105989,
-0.0067997696,
-0.012388974,
-0.011835205,
-0.021094741,
0.009684521,
-0.017179722,
0.0155055355,
-0.0034803746,
0.011577639,
-0.03327766,
0.0020347796,
0.013625297,
0.017205479,
-0.01500328,
-0.019162988,
0.009092117,
-0.0005384761,
0.015788859,
-0.009813304,
-0.0011010991,
0.008113362,
-0.0022939565,
-0.015067671,
-0.008802353,
0.018454678,
-0.008409563,
-0.032942824,
-0.009414075,
-0.030212613,
-0.0099098915,
0.008795914,
-0.03531244,
0.023567384,
-0.013367729,
0.008808793,
-0.011474611,
-0.014179066,
0.013174554,
-0.026246082,
-0.031062584,
-0.0037604787,
0.005930481,
0.0007803476,
0.017308505,
0.029362643,
-0.010296242,
0.012633664,
-0.009356122,
0.0006696743,
0.007862234,
0.008525469,
-0.029903533,
0.0032389055,
0.010656836,
-0.009497784,
-0.017681977,
0.010798498,
0.01859634,
-0.013651053,
0.0025515235,
-0.037913866,
0.0058564306,
-0.022240914,
0.006625912,
-0.007469444,
0.0112492405,
0.03147469,
0.014629807,
0.019407677,
-0.032994337,
-0.010122385,
0.008158436,
0.00757891,
0.005689012,
-0.008119801,
-0.025293084,
-0.021596996,
0.01172574,
-0.014616929,
0.03000656,
-0.025975635,
-0.03320039,
0.01890542,
0.0044043963,
0.0103026815,
-0.024597652,
-0.021081863,
-0.0082163885,
-0.011223484,
0.019021327,
0.0030521695,
0.0042144405,
0.00020474567,
0.0069414317,
-0.057540476,
0.0445591,
-0.0015735736,
-0.0036703304,
0.028795995,
0.02797178,
0.017102452,
0.010405708,
-0.014526781,
0.026709702,
0.013651053,
0.008003896,
0.027405133,
0.0006362711,
0.010450782,
-0.0019237038,
-0.009311048,
-0.019034205,
-0.0026448916,
0.020283405,
0.036909357,
0.05563448,
0.024623409,
0.027791483,
-0.026786972,
0.00097151066,
-0.0074887616,
-0.0009505834,
0.021893198,
0.0017450167,
0.008641374,
-0.019961445,
-0.012041259,
-0.0024549358,
-0.015170699,
0.010740546,
-0.017785003,
0.014539659,
0.0020444384,
-0.010534491,
0.014642686,
-0.0006233927,
0.026683945,
-0.016419899,
-0.02009023,
-0.0032389055,
0.035106387,
-0.018776637,
-0.010379951,
-0.014191944,
0.024752192,
-0.011590517,
0.0035383273,
0.005196415,
0.0040985355,
-0.0023551285,
0.012768886,
-0.00037649056,
-0.0020460482,
0.02047658,
0.0032550034,
-0.012401853,
0.0057083294,
0.0011888329,
-0.025602164,
-0.028795995,
-0.007688376,
0.04594996,
0.033148877,
-0.012131408,
-0.0070122625,
0.012009063,
-0.013052209,
-0.028976291,
-0.011777253,
0.011596956,
-0.0246878,
-0.0024710337,
0.032247394,
-0.013651053,
0.001031073,
0.017256992,
-0.01257571,
0.00084272714,
-0.021867441,
0.010650397,
0.013934377,
0.024262816,
-0.021403821,
-0.014616929,
0.018506192,
0.0032453446,
-0.0061075585,
-0.0141661875,
0.01687064,
0.0047585513,
-0.01617521,
0.0044720075,
0.004839041,
0.013715445,
0.0050225575,
0.0149131315,
-0.010167459,
-0.018016815,
-0.014977523,
0.008615618,
-0.008139119,
0.0069414317,
0.008461077,
0.032015584,
0.023837829,
0.010676154,
0.034256417,
0.016342629,
0.029723236,
0.017128209,
-0.0023406404,
0.029130831,
-0.0076304236,
0.0007300416,
0.0102254115,
-0.010592445,
-0.000110270885,
0.015170699,
0.02328406,
-0.0025128885,
0.005460421,
0.0104701,
0.016445655,
-0.012240874,
-0.014230579,
0.0017417971,
-0.008229267,
0.0061783893,
0.0002730613,
-0.014114673,
-0.016200967,
-0.015441144,
-0.013103723,
0.006909236,
-0.025692312,
0.026194567,
-0.008795914,
-0.009568616,
-0.010656836,
-0.018274382,
-0.020837173,
0.0017997497,
-0.01477147,
0.029877776,
-0.005814576,
-0.023090884,
0.013013574,
-0.00632971,
-0.02491961,
-0.0013135918,
-0.005119145,
0.013457878,
0.0031712942,
0.016909275,
-0.0019816563,
0.034797307,
0.025949879,
-0.00021430383,
-0.017849395,
-0.0016242821,
0.02735362,
0.0038152118,
-0.014784348,
-0.007063776,
-0.018506192,
-0.000014903171,
0.021403821,
0.004951726,
-0.008660692,
-0.013380608,
-0.005186756,
0.0041049747,
-0.027482403,
0.0117193,
0.003586621,
-0.026529405,
0.010334877,
-0.013148798,
0.011706422,
-0.004188684,
-0.01813272,
-0.0008765328,
-0.01281396,
-0.00035334978,
-0.032453448,
0.0067096213,
0.012054137,
-0.00092724134,
-0.01788803,
-0.018686488,
0.015183577,
0.026027149,
-0.0012830058,
0.01039283,
-0.0020524873,
0.00006630339,
0.021841684,
-0.014501024,
0.021313673,
0.01132651,
-0.039897133,
0.015466901,
-0.012582149,
0.026452135,
-0.008770158,
-0.029671723,
0.031938314,
-0.0128268385,
-0.021081863,
-0.027611187,
-0.004626548,
0.0016387703,
0.01953646,
-0.009813304,
-0.036291197,
-0.014037403,
0.024494626,
-0.02562792,
0.010122385,
-0.0013659102,
-0.0019703878,
-0.005824235,
-0.0021764415,
0.020747025,
0.003415983,
0.012466244,
-0.029877776,
0.017849395,
-0.0018190672,
-0.019317528,
0.012318144,
-0.020193256,
-0.012047698,
0.010534491,
-0.0016548682,
-0.017862273,
-0.005218952,
-0.027044538,
-0.009736034,
0.0318868,
0.008873184,
0.028667212,
-0.019420555,
0.015454022,
0.008699327,
-0.0089246975,
0.008222828,
-0.036316954,
-0.011809449,
-0.009362562,
0.030444425,
0.0066838646,
0.017321384,
-0.0033934456,
0.0016419899,
0.028383888,
0.020605363,
0.01164203,
-0.028718725,
-0.012601468,
-0.0104701,
-0.02039931,
0.022086373,
-0.021635631,
0.015170699,
-0.0038731643,
-0.010206094,
0.002532206,
0.010953038,
-0.0047810883,
-0.028177833,
0.035982113,
-0.008660692,
0.026555162,
0.0039633126,
0.008377368,
-0.02601427,
-0.011603395,
0.0015381582,
-0.015312361,
0.005602083,
-0.015363874,
0.016432777,
0.012221556,
-0.011526125,
-0.013226068,
0.0071217287,
-0.015247969,
-0.019137232,
0.0019575094,
-0.023618897,
-0.023155278,
-0.004459129,
-0.013483634,
-0.03023837,
0.011094701,
-0.006613034,
-0.042472806,
0.019420555,
-0.007385735,
-0.022459846,
0.002289127,
0.0155828055,
0.039407756,
-0.014140431,
0.024623409,
-0.0031374884,
-0.0000771695,
0.010502296,
0.011262119,
-0.024031004,
0.013251824,
0.020219013,
0.01195111,
-0.021609874,
-0.011448855,
-0.009291731,
0.026735459,
-0.007463005,
-0.019175867,
0.023786316,
0.025872609,
0.029439913,
-0.00042015623,
0.028950535,
-0.011963989,
0.018531948,
0.0068126484,
-0.008602739,
0.003477155,
-0.0318868,
-0.0229621,
0.023837829,
-0.015222212,
0.026632432,
0.022292428,
-0.019394798,
0.015479779,
-0.022575751,
0.0064584934,
-0.005180317,
0.0058499915,
0.022575751,
0.012569271,
-0.0064520543,
-0.008506152,
-0.0071088504,
0.004397957,
-0.009916331,
-0.00695431,
0.03399885,
-0.022987857,
0.028280862,
0.010212533,
0.017179722,
0.015634319,
0.008589861,
-0.0024903512,
-0.018325895,
-0.019678121,
-0.004336785,
0.015827494,
-0.011513246,
-0.03132015,
0.020965956,
0.00531554,
-0.01625248,
-0.050998274,
-0.026349109,
0.026709702,
-0.028100563,
-0.030573208,
-0.011352267,
0.011339389,
0.027688457,
0.0035286683,
-0.039665323,
-0.013187433,
0.0027801143,
0.0071539246,
-0.0061622914,
-0.0013610808,
0.02024477,
-0.036162414,
-0.0058660894,
-0.034951847,
-0.016960789,
0.017527437,
-0.028667212,
-0.03641998,
0.008564104,
0.022846196,
0.0077720853,
-0.006774013,
-0.022163644,
0.0024082519,
-0.0147972265,
0.021468213,
-0.002203808,
-0.016844884,
0.001899557,
-0.023309818,
-0.0066452296,
0.021918954,
-0.007546714,
0.019085718,
0.00016208613,
-0.027920267,
0.015235091,
0.0075273965,
-0.011184849,
-0.047083255,
0.025795339,
-0.0015775982,
-0.011751496,
-0.0047649904,
-0.021468213,
0.004001948,
0.0043045892,
-0.012054137,
-0.008776597,
-0.0085705435,
0.03296858,
0.03726995,
0.024649166,
-0.028795995,
-0.003960093,
-0.042962182,
-0.0029877776,
-0.01390862,
-0.004504204,
0.009813304,
0.033380687,
0.030032316,
-0.019987201,
-0.022987857,
-0.013509391,
-0.017849395,
-0.04133951,
0.011822327,
0.006774013,
-0.03554425,
0.0035190096,
-0.015660075,
0.009169387,
-0.006838405,
-0.017179722,
-0.0276627,
-0.016226724,
-0.00273504,
-0.014861618,
0.035415467,
-0.0155441705,
-0.038506273,
-0.019781148,
0.038119923,
-0.020206135,
-0.015286604,
0.0032711013,
-0.006838405,
0.015029036,
-0.022021981,
0.032556474,
0.010167459,
0.010978795,
0.0351579,
0.002335811,
-0.024468869,
-0.011680665,
0.006258879,
-0.02547338,
0.010412147,
0.0018287259,
-0.003931117,
0.024984002,
-0.0034674963,
-0.056304153,
0.0063747843,
-0.010753424,
-0.02133943,
0.0016114038,
-0.009884135,
-0.0012524197,
0.0014785958,
-0.013560904,
-0.008377368,
-0.03250496,
-0.011268558,
0.003367689,
0.0020991713,
0.007095972,
0.006081802,
-0.026658189,
-0.0013538367,
-0.010759863,
-0.019587973,
0.0095171025,
-0.013921498,
-0.0052060736,
0.028358132,
0.0070444583,
-0.0093174875,
0.019961445,
-0.00044712028,
0.005148121,
-0.0034803746,
-0.009336805,
-0.0018641414,
-0.0076626195,
0.014578294,
-0.0012725422,
-0.0049098716,
-0.006960749,
-0.031139854,
-0.005689012,
-0.01648429,
0.015866129,
0.1763819,
0.0026867462,
0.023168156,
0.050354354,
0.015634319,
0.025164299,
0.010025797,
0.014397997,
-0.009137191,
-0.004990361,
0.012698055,
0.00023201156,
-0.013792715,
0.0035383273,
0.0093174875,
-0.016522925,
-0.034050364,
-0.007804281,
-0.024430234,
0.020605363,
-0.0000108598215,
-0.009633007,
0.003805553,
-0.0017337481,
0.02203486,
0.0039246776,
-0.0031117317,
0.0071989987,
0.016909275,
-0.013625297,
-0.0057952586,
-0.020128865,
0.0085319085,
0.0025016197,
-0.0013981061,
0.0000945754,
0.019497825,
0.016303994,
0.01851907,
0.0149517665,
0.0049485066,
0.0048647975,
-0.012923426,
-0.013032892,
0.004719916,
0.0067933304,
-0.018956933,
-0.0025965977,
-0.03374128,
-0.0017917007,
-0.032170124,
0.0136124175,
0.031448934,
0.019858418,
0.016162332,
0.027405133,
0.013805593,
-0.004352883,
-0.0082936585,
0.018377408,
-0.0276627,
0.01882815,
-0.00073044404,
0.0031471471,
-0.018622097,
0.005299442,
-0.03381855,
-0.018763758,
0.014320727,
-0.012884791,
-0.013651053,
0.0040599005,
-0.021712901,
0.013032892,
0.008744401,
-0.022575751,
-0.014578294,
0.0035930602,
0.010412147,
0.019794026,
0.0033709086,
0.007095972,
-0.040231973,
0.023992369,
-0.022021981,
-0.0214167,
0.023837829,
0.006468152,
-0.027070295,
-0.0031230003,
-0.008448198,
-0.022987857,
-0.014230579,
-0.011667787,
0.019497825,
0.008448198,
-0.0070573366,
0.0039343364,
-0.02063112,
-0.017772125,
-0.000029806342,
0.03649725,
0.0016886739,
0.015827494,
-0.034101877,
0.0003036474,
-0.0010350975,
-0.014385119,
0.004510643,
0.01117841,
0.000105441504,
-0.018248625,
-0.011081822,
-0.026555162,
0.004990361,
-0.012021941,
-0.0049420674,
-0.032685257,
0.0029668503,
0.009420514,
-0.016123697,
-0.024314329,
0.00007364807,
0.039665323,
-0.007598228,
0.0142048225,
-0.017372897,
0.009871257,
0.015557049,
-0.0428334,
0.004581474,
-0.02258863,
0.011056066,
-0.014488146,
0.017643342,
0.015608562,
-0.009291731,
-0.0037669179,
-0.009954966,
-0.0030280226,
-0.024159787,
-0.020991713,
0.033020094,
0.0028396766,
0.01383135,
0.0028074807,
-0.03327766,
-0.014681322,
0.0014737664,
-0.0068577225,
0.004172586,
-0.027405133,
-0.026709702,
0.012846156,
0.03822295,
-0.030418668,
-0.014423754,
-0.002366397,
0.012562832,
0.007540275,
-0.021159133,
-0.0050128987,
0.02437872,
-0.0077720853,
0.001000487,
0.017102452,
-0.15958853,
0.04252432,
0.016213845,
-0.022717413,
0.014436632,
-0.0112106055,
0.035750303,
-0.023103762,
-0.002632013,
0.0122730695,
0.022305306,
-0.021287916,
-0.022176523,
-0.048345335,
0.027250594,
-0.003821651,
0.0011904427,
0.04576966,
0.022395454,
0.04682569,
0.020759903,
-0.018699367,
0.010270486,
-0.036085144,
0.02781724,
0.002781724,
0.013522269,
0.0070058233,
0.017669098,
0.0015590854,
0.0027720653,
-0.011706422,
0.001773993,
-0.012698055,
0.0121571645,
-0.012221556,
-0.018184233,
-0.0069671883,
0.0056761336,
0.011635591,
0.012556393,
0.0070058233,
0.01000004,
0.0050676316,
-0.0149517665,
-0.0018947275,
0.015840372,
0.008634935,
0.0129685,
0.0035254487,
0.011712861,
0.004710257,
0.0089246975,
0.0026996245,
0.028332375,
0.008351611,
0.0028879703,
0.013026453,
0.003250174,
-0.0075917887,
0.0023309817,
-0.028074807,
-0.006400541,
0.0030956338,
0.019987201,
-0.012859034,
-0.03680633,
0.0093174875,
-0.024726436,
0.00804897,
-0.014307849,
-0.024777949,
0.044533342,
0.0060978997,
0.01602067,
0.016381264,
-0.0009868037,
-0.014346484,
-0.007978139,
-0.0034031044,
-0.017720612,
0.008834549,
-0.0135351475,
-0.0063651255,
-0.003966532,
0.011822327,
0.0001784859,
-0.004188684,
-0.0046909396,
-0.011146214,
0.016188089,
-0.034179147,
0.0009908281,
-0.04000016,
0.0077463286,
0.0075660315,
0.012202239,
-0.006036727,
0.00523505,
-0.014024525,
0.0035190096,
-0.010025797,
-0.014397997,
0.004111414,
0.012434049,
0.0055022757,
0.0013602759,
0.009175826,
0.058828313,
-0.010586006,
0.02352875,
0.02413403,
0.002438838,
0.016857762,
-0.035647277,
0.030521695,
0.0017595048,
-0.012562832,
0.01406316,
-0.0047585513,
0.028486915,
0.003264662,
0.008461077,
0.017385775,
0.010463661,
-0.005846772,
-0.11271133,
0.011371585,
0.0142434575,
0.008680009,
0.00030163515,
0.008325854,
-0.006455274,
0.0012669079,
0.0063812234,
0.037321463,
0.015904764,
-0.017772125,
-0.0018850687,
-0.01726987,
0.004124292,
0.014423754,
-0.031448934,
0.008911819,
-0.022382576,
0.02288483,
-0.013586661,
-0.010070872,
0.0044945446,
0.004156488,
-0.009484906,
-0.021197768,
-0.01484874,
0.03508063,
0.01757895,
0.022215158,
0.0073342216,
-0.009311048,
0.010199655,
-0.01211209,
-0.01156476,
-0.016316872,
0.005354175,
-0.0067933304,
0.021815928,
-0.025293084,
0.004742453,
-0.011539003,
0.017694855,
-0.022331063,
0.028615698,
-0.004497764,
-0.022614386,
0.005750184,
0.0050515337,
0.007727011,
-0.004391518,
-0.0045621563,
-0.0156214405,
-0.02531884,
0.009652325,
-0.008937576,
-0.0027366497,
0.00030062904,
0.00203156,
-0.008023214,
-0.004352883,
0.0034192025,
-0.009111434,
0.008795914,
0.015840372,
-0.016600195,
-0.010624641,
-0.014604051,
0.013651053,
-0.042395536,
0.0030763163,
-0.0072633903,
-0.003150367,
0.022498481,
-0.022859074,
-0.0015663295,
-0.021584118,
0.0038796035,
0.005821015,
-0.01008375,
-0.009311048,
-0.02009023,
-0.015273726,
-0.008023214,
0.01031556,
0.04749536,
0.020618241,
0.0013916669,
-0.01765622,
-0.025447624,
-0.008886063,
0.022575751,
0.0032614425,
-0.0031761236,
-0.021790171,
0.019665243,
0.016677465,
0.0038152118,
0.04546058,
0.018325895,
-0.021249281,
-0.008654253,
-0.05241489,
0.028692968,
0.0045299605,
0.0068899184,
0.0043882984,
0.0022327842,
-0.014629807,
-0.0024549358,
0.0029942167,
0.009047043,
-0.0009087287,
0.015376752,
-0.022472724,
-0.007340661,
-0.024417356,
-0.018171355,
0.01828726,
0.02273029,
0.03281404,
0.01023829,
0.0058564306,
0.01765622,
0.02461053,
0.016497169,
-0.040386513,
0.030573208,
-0.028950535,
-0.0038184314,
-0.037939623,
0.0033709086,
0.0129685,
-0.008113362,
-0.020837173,
0.0036606714,
-0.02220228,
-0.04157132,
0.009600812,
0.026220325,
-0.0030103147,
0.012517758,
-0.017321384,
-0.024365842,
-0.004201562,
-0.017372897,
-0.029027805,
0.008499713,
-0.023567384,
0.001812628,
0.0036832087,
-0.0027785045,
0.028512672,
0.00070991914,
0.019034205,
-0.04667115,
-0.011687105,
-0.0043110284,
0.0117193,
-0.019266015,
-0.0044720075,
-0.051384624,
0.022060616,
0.013766958,
0.021790171,
-0.008132679,
-0.027224835,
-0.03366401,
-0.008589861,
-0.011294315,
0.010920842,
-0.030805018,
-0.0059047244,
0.013779837,
0.019691,
0.0025740606,
0.016522925,
0.005025777,
-0.012929865,
-0.011146214,
-0.010399269,
0.03147469,
0.002992607,
-0.003180953,
-0.008802353,
0.034823064,
0.027070295,
-0.0027012343,
-0.025846852,
0.016085062,
0.01141022,
0.019369042,
-0.009098556,
0.0002042426,
-0.0054121274,
-0.006104339,
-0.00055417157,
-0.009439832,
0.003272711,
0.0065518613,
-0.011661348,
0.01398589,
0.004150049,
0.013251824,
0.0014085697,
-0.013548026,
-0.017681977,
-0.03031564,
-0.018660732,
-0.02633623,
-0.03726995,
-0.00500002,
-0.0052736853,
0.018699367,
0.010096628,
-0.009665203,
-0.037321463,
-0.0055763265,
-0.029826263,
0.027997537,
-0.015994914,
0.035209414,
-0.0049935807,
0.04679993,
0.012163604,
0.01515782,
0.020605363,
0.011745057,
0.01765622,
0.00009945509,
0.019575095,
0.010586006,
0.0018512631,
-0.015260847,
-0.0085705435,
-0.00288958,
0.0023164935,
-0.0019800465,
0.038789596,
0.017141087,
0.0046684025,
0.07016126,
-0.0129427435,
-0.034874577,
-0.0039117993,
0.0024130812,
0.007340661,
0.0064713717,
0.0092788525,
-0.026915755,
0.0028847507,
-0.0018705806,
-0.0062620984,
0.002937874,
-0.024327207,
-0.028976291,
0.0078107202,
-0.023425722,
-0.005666475,
-0.027920267,
-0.009085678,
0.013084405,
-0.01070835,
0.016690344,
0.01945919,
-0.013213189,
-0.024108274,
0.022987857,
-0.008686448,
-0.005096608,
-0.030933801,
0.008615618,
0.010586006,
-0.04425002,
-0.027327863,
0.025602164,
0.0049646045,
0.012144286,
-0.041983426,
0.007868673,
0.007675498,
-0.01602067,
0.014333606,
-0.010856451,
-0.007508079,
-0.007340661,
-0.012627224,
-0.031191368,
-0.020347796,
-0.013251824
] |
Cytotoxic T-lymphocyte (CTL) responses to human immunodeficiency virus arise early after infection, but ultimately fail to prevent progression to AIDS. Human immunodeficiency virus may evade the CTL response by accumulating amino-acid replacements within CTL epitopes. We studied 10 CTL epitopes during the course of simian immunodeficiency virus disease progression in three related macaques. All 10 of these CTL epitopes accumulated amino-acid replacements and showed evidence of positive selection by the time the macaques died. Many of the amino-acid replacements in these epitopes reduced or eliminated major histocompatibility complex class I | [
-0.030390218,
-0.009669615,
-0.013760606,
-0.016642895,
0.0058210283,
0.035543803,
-0.0060833567,
0.0046023647,
-0.02773373,
0.008819539,
0.018728238,
0.0038120598,
0.014650529,
-0.0041208765,
-0.011336561,
0.011104118,
0.03567663,
-0.021796482,
-0.024824876,
0.0043134717,
-0.03907693,
-0.00089490425,
0.00779015,
-0.035915714,
0.0062859138,
-0.0038751513,
-0.0013871846,
-0.052385937,
-0.02118549,
0.00015274803,
0.0064253793,
-0.00800931,
-0.01623114,
0.003285743,
-0.008162058,
-0.016111597,
0.0008313976,
-0.0061165625,
0.023988083,
0.012717934,
0.015434193,
0.033578005,
0.0023360488,
0.0053528226,
0.012465568,
0.0029835675,
0.0011481007,
-0.015181826,
-0.03379052,
0.011270149,
0.02141129,
0.0047650747,
0.010552897,
0.0035663347,
-0.01051305,
-0.015779536,
-0.0063722497,
0.013488316,
0.0005790313,
-0.023775565,
-0.00403122,
0.005654998,
-0.008381219,
0.01884778,
0.0041109147,
0.016496789,
0.0010152764,
0.0129703,
-0.0021069266,
0.01809068,
0.019153276,
0.02424045,
-0.013216026,
0.000882452,
0.03498594,
-0.012120225,
-0.023988083,
0.005312975,
-0.0016096655,
0.010001676,
0.024758464,
-0.023124725,
-0.0072389287,
0.03007144,
0.022301214,
0.0033089875,
0.012478851,
0.0108916,
0.022885641,
-0.0042869067,
0.0006134826,
0.001683549,
0.017121064,
0.028716631,
-0.021344878,
0.028716631,
0.0002457251,
0.030390218,
-0.007225646,
-0.017187474,
-0.012385873,
0.011070912,
-0.003061602,
-0.005784502,
-0.008474195,
0.013289079,
-0.0008401142,
-0.004516029,
0.00648515,
-0.01508885,
-0.016815567,
0.016908543,
-0.014942743,
-0.047072962,
0.012332744,
0.006674425,
0.03012457,
0.004967632,
-0.008022592,
-0.0055387765,
0.0026847129,
0.015500605,
0.025515564,
-0.007849921,
0.04112243,
0.011748317,
-0.019737704,
-0.021650374,
-0.006946715,
-0.0047650747,
0.035278156,
0.024718618,
0.006531639,
0.0040843496,
-0.004924464,
0.004227136,
-0.026551593,
-0.0044097695,
0.012512057,
0.0060368683,
0.016855413,
0.030044874,
0.015460758,
0.020773733,
0.011290072,
0.0276806,
0.019565031,
0.006352326,
-0.009961829,
0.005322937,
-0.016603047,
-0.021530831,
0.010008317,
-0.02783999,
0.0075577074,
0.00806244,
-0.017718771,
0.025953883,
-0.017745337,
-0.020547932,
-0.008042516,
-0.011954194,
0.018462589,
0.0063324026,
0.0023692548,
0.017067933,
0.021570679,
0.019246252,
0.0062361048,
-0.013056637,
-0.006488471,
0.021876175,
-0.0007981915,
0.005953853,
-0.013866865,
0.024094343,
0.0028424417,
0.032807622,
-0.030310523,
-0.023735717,
-0.0045093875,
0.031771593,
0.022540297,
-0.0062460667,
-0.0068338146,
0.005299693,
0.029566707,
-0.0011796466,
-0.0038020979,
-0.025967166,
-0.0040345406,
0.007909692,
0.00256019,
-0.043221053,
-0.6452077,
-0.035650063,
0.013030072,
-0.009237936,
-0.004549235,
0.02429358,
0.016603047,
0.0046654562,
-0.036765788,
0.027003197,
-0.0059737763,
0.022261366,
0.01819694,
-0.024891289,
-0.016523354,
-0.04096304,
-0.012704652,
-0.019219687,
0.002087003,
-0.00044205613,
-0.012020607,
-0.004011296,
0.0051436243,
0.01933923,
-0.010466562,
-0.01672259,
0.015912361,
-0.004090991,
-0.009523508,
0.030708997,
0.0008558871,
0.010858393,
-0.0061530895,
-0.015885796,
0.06715601,
0.008699997,
-0.0031844645,
-0.00266977,
0.012073737,
0.021398008,
0.00850076,
-0.00898557,
0.0067674024,
0.010061447,
-0.010984576,
0.025289763,
-0.007783509,
0.013787171,
0.014318468,
-0.01666946,
0.017904727,
0.008374577,
-0.04210533,
0.0069002267,
0.00877305,
-0.004778357,
0.02718915,
-0.022593427,
0.027707165,
0.0073451884,
-0.005628433,
-0.0018711635,
0.0047683953,
-0.018914191,
-0.017333582,
0.002712938,
-0.008035875,
0.017134344,
0.01127679,
0.0005246563,
0.020986252,
0.018542284,
-0.009410608,
-0.009928622,
0.015553735,
0.018582132,
0.0014452953,
-0.026710983,
0.00031857096,
0.0066046924,
-0.006571486,
-0.0057678986,
-0.013734041,
0.007969463,
-0.012100301,
-0.005571983,
-0.013468392,
0.015806101,
-0.0049875556,
0.030735562,
0.023297396,
-0.005127021,
0.0011298374,
-0.04412426,
-0.024798311,
0.017825032,
-0.012292896,
-0.00838786,
-0.018529002,
-0.021929305,
-0.009430531,
-0.02260671,
0.00925786,
0.0059903795,
0.03368426,
0.0026730907,
-0.012830835,
0.014318468,
0.06689036,
-0.027202433,
-0.0136277815,
-0.010898241,
-0.0052764486,
-0.01749297,
0.004320113,
-0.01503572,
0.0047185863,
0.024585793,
0.012080377,
-0.028238464,
0.020667473,
0.005246563,
0.007219005,
0.00066453696,
0.0041042734,
0.022194954,
-0.016111597,
-0.018475872,
0.0054889675,
-0.006385532,
-0.0007691362,
-0.006003662,
0.01552717,
-0.008089005,
0.021597244,
0.013109766,
0.022473885,
0.009569997,
-0.026976632,
-0.023881823,
-0.004592403,
-0.0039681285,
0.0018778046,
0.0059239673,
-0.013103126,
-0.0012186636,
0.0021534152,
0.0047285478,
0.0033421936,
-0.009211371,
0.030310523,
-0.002457251,
-0.0013572992,
0.013680912,
0.01677572,
-0.003911678,
-0.0071525928,
-0.0385722,
0.006571486,
-0.01334885,
-0.00871992,
0.026883654,
0.02151755,
0.013116407,
-0.00013313569,
-0.007650684,
0.018781368,
0.026206251,
-0.007863203,
-0.05060609,
0.0036393881,
-0.03328579,
-0.019193122,
0.019219687,
-0.014889613,
0.01884778,
-0.012379232,
-0.0101345,
-0.024917854,
-0.0015125376,
0.012140148,
-0.012757782,
0.023297396,
-0.0025568693,
0.023563046,
-0.011914347,
0.021623809,
0.0039249603,
0.022566862,
0.044363342,
-0.0075112185,
-0.024120908,
-0.020773733,
-0.000615558,
0.016974956,
-0.0018744841,
0.014597399,
0.024267014,
0.0126714455,
0.026923502,
-0.01149595,
-0.0067375167,
0.011070912,
-0.0037390064,
0.014863048,
-0.02408106,
-0.0073783942,
-0.035464108,
0.020308848,
0.010107935,
-0.004227136,
-0.01312969,
-0.0019242932,
-0.003121373,
0.0012053812,
-0.002424045,
0.008407784,
0.009981752,
-0.003994693,
-0.024931137,
-0.0020006672,
0.010519691,
0.018103963,
-0.02908854,
-0.017426558,
0.008148775,
0.0028258387,
0.028583806,
-0.0001525405,
-0.008959005,
0.00019321797,
-0.01607175,
0.022274649,
0.008587096,
0.014265339,
0.005840952,
0.023230985,
0.0019292742,
0.0350922,
0.005953853,
-0.020229153,
0.008414425,
-0.0013124709,
0.0018595413,
-0.011077553,
0.0026249418,
0.013574651,
0.002108587,
-0.004183968,
0.043167923,
-0.014477857,
-0.0016876998,
-0.018422741,
-0.012538621,
-0.0050174408,
-0.0069932034,
0.009450454,
0.02053465,
0.048507463,
0.013760606,
0.022327779,
-0.024267014,
0.008341371,
-0.013880148,
0.009749309,
0.013328927,
-0.014411446,
-0.007949539,
-0.00085671723,
0.004134159,
-0.02783999,
-0.0114162555,
0.011489309,
-0.027335258,
0.01122366,
0.022009,
-0.0005254865,
0.00041154804,
0.015288087,
0.010493126,
-0.026299227,
-0.022832511,
0.01666946,
0.010639233,
-0.012292896,
-0.0042769453,
-0.029301059,
-0.0077503026,
-0.01154908,
0.010061447,
-0.0068271733,
0.008487478,
0.00035758814,
0.010094653,
-0.007584272,
-0.029699532,
0.031426247,
-0.009437173,
0.0050639296,
-0.0020737206,
-0.0067209136,
-0.015314651,
-0.015859231,
-0.0031313347,
0.02892915,
0.014770071,
0.0043068305,
-0.03572976,
-0.0130234305,
-0.004994197,
0.0077237375,
-0.005571983,
0.0073451884,
-0.011788163,
0.020800298,
0.014212209,
-0.01547404,
0.02244732,
0.02021587,
-0.014969308,
-0.0003416077,
-0.036659528,
-0.009895416,
-0.029513577,
0.02887602,
0.024771746,
0.0039316015,
0.014597399,
0.0113166375,
0.020773733,
-0.0032624989,
-0.022540297,
0.033152964,
-0.021318313,
-0.03360457,
-0.011469386,
-0.0037190826,
-0.0024605717,
0.03498594,
0.027600907,
0.0040876702,
-0.0072920583,
-0.007869844,
0.008215188,
0.01029389,
0.0066445395,
0.034720294,
0.009244577,
0.00779015,
0.0024223847,
0.023124725,
0.028185334,
0.0019541788,
-0.024426404,
0.007876486,
-0.000057851244,
-0.0024124228,
0.017121064,
-0.0059306086,
-0.024718618,
-0.0031130714,
0.015938926,
0.025090525,
-0.0056151506,
0.031080905,
0.023416938,
0.0016868697,
0.012087018,
-0.000020221993,
0.004147441,
0.009364119,
0.026033578,
-0.0052598454,
-0.038545635,
0.01689526,
-0.02522335,
-0.02348335,
-0.01726717,
0.0069799214,
0.009490302,
-0.0097825155,
-0.013109766,
-0.003612823,
0.002218167,
-0.00495767,
-0.013016789,
0.008593737,
-0.0097094625,
-0.017745337,
-0.016270986,
0.0018346368,
0.0009563355,
-0.020069763,
-0.014823201,
0.020454954,
-0.023629457,
-0.011117401,
0.01623114,
-0.01334885,
-0.00386851,
0.0027345219,
-0.0010161065,
0.013189461,
0.026777396,
-0.0145575525,
-0.012538621,
-0.015713124,
-0.020826863,
0.022460602,
0.019671291,
0.011854576,
-0.020826863,
-0.0010941408,
0.0017449803,
-0.00583099,
-0.006073395,
0.0021583962,
0.015925644,
-0.0061630514,
0.0065449215,
0.01809068,
0.0430351,
-0.017479688,
-0.018595412,
-0.016111597,
-0.02985892,
0.002545247,
-0.0135015985,
-0.0068271733,
-0.028902585,
0.01623114,
0.0100216,
-0.0022795985,
-0.032781057,
0.023616174,
-0.00844763,
-0.010672439,
-0.0036958384,
0.013043354,
0.032488845,
0.021570679,
0.015434193,
0.009623126,
-0.03557037,
-0.0350922,
-0.032170065,
0.011037706,
0.0007882297,
-0.0064785094,
-0.0012286255,
0.02016274,
-0.018914191,
-0.00003164956,
-0.019790832,
-0.01939236,
0.017639078,
0.02413419,
-0.02380213,
-0.03254197,
-0.0015216693,
-0.004147441,
0.019020451,
0.013475033,
-0.012452286,
-0.0017483009,
0.007311982,
0.0011622133,
-0.010001676,
0.00975595,
-0.033312354,
-0.0046322504,
0.04407113,
-0.0012468889,
-0.011828011,
0.013986407,
-0.007843279,
-0.02190274,
0.0079761045,
-0.026989914,
-0.018914191,
0.004871334,
0.008620302,
0.028397853,
0.030310523,
0.035171896,
-0.022115258,
0.03442808,
0.024612358,
0.0069334325,
0.0059040436,
-0.0077503026,
0.022885641,
-0.015925644,
-0.0071658753,
0.016961673,
-0.013368774,
0.0140793845,
-0.021583961,
0.016603047,
0.015766254,
-0.0025684915,
-0.0301777,
0.00031504282,
-0.04391174,
-0.018236788,
0.024785029,
0.0036858765,
0.011721752,
-0.039342582,
-0.0018778046,
0.017639078,
0.028052509,
-0.006003662,
0.012558545,
0.034507774,
0.005678242,
-0.0053926697,
-0.0044197314,
-0.001645362,
-0.00065997115,
-0.018675108,
0.0008658489,
0.014159079,
0.03567663,
-0.0066877077,
-0.009337554,
0.028105639,
-0.005153586,
0.010546256,
0.0042869067,
-0.018077398,
-0.029247928,
-0.011595569,
-0.021916023,
-0.00746473,
-0.014026254,
-0.025502281,
-0.0212519,
-0.013368774,
-0.0051403036,
-0.0065382803,
0.007756944,
-0.013103126,
-0.02599373,
0.040405177,
0.004609006,
0.028822891,
-0.026126556,
0.020494802,
0.014730223,
0.0005528815,
-0.02980579,
-0.018329764,
0.004124197,
0.028371288,
0.021504268,
0.03618136,
-0.0005732202,
-0.0024904571,
-0.0020039878,
0.019485336,
-0.012279614,
-0.039156627,
0.021331595,
0.0043566395,
0.010154424,
-0.027388386,
-0.020720603,
-0.017453123,
0.01231282,
-0.015181826,
-0.0046123266,
0.0029453808,
-0.02058778,
-0.038094033,
0.025210068,
0.0038983957,
0.0076905317,
0.009556714,
-0.023563046,
-0.012359309,
-0.04412426,
-0.0049443874,
0.0024921175,
-0.0005815217,
0.019365795,
0.004914502,
-0.0108384695,
-0.00018948228,
-0.017997704,
0.0140793845,
-0.0050041587,
0.009324271,
0.039342582,
-0.0021716787,
-0.004300189,
0.00014455029,
-0.007849921,
0.0035198461,
-0.003655991,
0.010911522,
-0.013880148,
-0.028025944,
-0.011754958,
0.026046861,
0.028690066,
-0.012937095,
0.0012726235,
-0.014119232,
-0.0025867547,
-0.032568537,
-0.020255718,
0.03126686,
-0.030868387,
-0.0076573254,
0.0046056854,
0.008912516,
0.027228998,
0.028052509,
0.011197096,
-0.009437173,
0.02898228,
-0.033418614,
0.007756944,
0.005850914,
0.012684728,
-0.007869844,
-0.009882134,
-0.02304503,
0.009995035,
0.014969308,
-0.021716787,
-0.03982075,
-0.022394191,
0.004406449,
0.018316481,
0.0037888153,
-0.014411446,
0.026950067,
-0.0008135493,
0.0111904545,
0.006515036,
-0.019724421,
0.024532663,
-0.02778686,
-0.0100216,
0.010473202,
-0.011861217,
0.0034069454,
0.0052930517,
-0.006368929,
-0.00069442246,
-0.0375893,
-0.022248084,
-0.014132514,
0.0016710968,
0.011748317,
-0.021490986,
-0.0031313347,
-0.0014336732,
-0.0052432423,
-0.0061796545,
0.006913509,
0.004648853,
-0.008042516,
-0.0016901903,
-0.009862211,
0.011834652,
-0.0035928995,
0.0018279955,
0.0026515068,
-0.030310523,
-0.014809919,
-0.0059604943,
-0.02653831,
0.031957544,
0.00077660754,
0.003197747,
-0.017931292,
-0.0070396923,
-0.057645783,
0.00056948455,
0.0056716013,
0.004090991,
0.008706639,
0.02369587,
-0.010400149,
0.0015781197,
-0.011104118,
0.0011846274,
-0.01318282,
-0.015992055,
0.021969153,
0.000031934924,
0.031771593,
0.018263353,
-0.016310833,
-0.007889768,
0.027707165,
0.0045857616,
-0.0072322874,
0.0126714455,
-0.0010144463,
0.012073737,
0.0055288146,
0.032488845,
-0.020348696,
-0.0017898085,
-0.0102606835,
-0.019405643,
0.008367936,
0.015195109,
-0.009032058,
-0.005206716,
-0.009802439,
-0.0055155326,
0.016735872,
0.0019209726,
-0.004097632,
-0.032435715,
0.0006720084,
-0.025382739,
-0.0008293222,
0.014703659,
-0.02506396,
-0.0057712193,
-0.004721907,
0.0038120598,
-0.0019060299,
-0.003911678,
-0.010606027,
0.0044097695,
0.0031612203,
0.007823356,
-0.011655339,
-0.0012942075,
0.02107923,
-0.034720294,
-0.008401142,
-0.00261498,
-0.005186792,
-0.042344414,
0.008055799,
0.02903541,
0.003665953,
0.014703659,
0.00088992337,
-0.01726717,
-0.014942743,
0.0065117152,
0.010479843,
-0.008686715,
0.0069599976,
-0.016682742,
-0.0076838904,
-0.009144959,
-0.011974118,
-0.013342209,
-0.0276806,
-0.005840952,
0.1889294,
-0.016974956,
-0.00068570586,
-0.000037797876,
-0.02348335,
-0.0017947895,
0.006521677,
-0.0061862953,
-0.014159079,
0.01219992,
0.018343046,
0.0071725165,
-0.012870682,
-0.0007143461,
-0.015713124,
-0.0050539677,
-0.0435664,
0.0007085351,
-0.015394346,
-0.009350836,
0.00925786,
0.012711293,
0.019139994,
0.007909692,
0.029672967,
-0.008892592,
-0.018263353,
0.020720603,
0.0031014492,
0.0006417078,
-0.038014337,
-0.0077503026,
-0.011217019,
0.0044263727,
0.005034044,
0.0101345,
-0.028238464,
-0.013003507,
0.009178164,
0.0027395028,
-0.004934426,
0.018024268,
-0.029619837,
-0.010865035,
-0.022194954,
0.032701362,
0.010147783,
-0.030655866,
0.007783509,
-0.0029570027,
-0.031134035,
-0.012100301,
0.0083015235,
-0.0043433574,
0.005376067,
0.0051237005,
0.01803755,
-0.0011937591,
-0.016576482,
0.033073273,
-0.01498259,
-0.0053860284,
-0.011535797,
0.034826554,
-0.008766409,
0.026099991,
-0.011688545,
-0.011522515,
0.021623809,
-0.023576327,
0.012478851,
-0.014384881,
-0.014637247,
0.0056051887,
-0.016749155,
-0.018396176,
0.019405643,
0.019565031,
0.00419393,
0.0103603015,
0.0037788537,
-0.015367781,
-0.031346552,
0.017572666,
-0.003622785,
-0.03001831,
0.044788383,
0.014291903,
-0.034135867,
0.023031747,
0.003061602,
-0.02706961,
-0.019458773,
-0.0071459515,
0.0107388515,
0.015487323,
0.0067574405,
0.0033953232,
0.021278465,
-0.022434037,
-0.018117245,
0.05371418,
-0.0029437204,
0.010924805,
0.0028607051,
0.00031960866,
-0.021398008,
-0.014504422,
0.008069081,
-0.028822891,
0.0034335102,
-0.034215562,
-0.0065615242,
-0.009125035,
0.0010800282,
0.029301059,
0.004569159,
-0.009636409,
0.02332396,
-0.0011887782,
0.02151755,
-0.022434037,
-0.005545418,
0.03432182,
0.006657822,
-0.0136012165,
-0.040006705,
0.0076639666,
0.016111597,
-0.03432182,
0.016324116,
-0.0018313162,
-0.023058312,
0.022978619,
0.0039415634,
0.012492133,
0.00010999519,
-0.034188997,
-0.018316481,
0.01770549,
-0.0086535085,
0.0007670608,
0.01825007,
-0.0041208765,
0.015540453,
-0.010420073,
0.002538606,
0.020295566,
-0.03389678,
-0.021344878,
0.010234118,
-0.031877853,
-0.0055387765,
0.00036215398,
-0.0057180896,
-0.016881978,
-0.005100456,
-0.0014942742,
-0.018077398,
0.01607175,
-0.030576173,
0.02429358,
-0.0004910351,
-0.011754958,
-0.012193278,
0.002223148,
-0.16703995,
0.014863048,
0.0005806916,
-0.007896409,
0.021929305,
0.0018512398,
0.020826863,
-0.0024306863,
-0.011562362,
0.029460447,
0.03394991,
-0.013773888,
-0.03650014,
-0.023111442,
0.010433355,
-0.010307172,
-0.03355144,
0.026989914,
0.029008845,
-0.0030665828,
0.017134344,
-0.031957544,
0.008852745,
-0.013076561,
0.0030317164,
0.042689756,
-0.0010418412,
-0.013853583,
-0.0034368308,
-0.0113166375,
-0.008666791,
0.010041523,
0.03588915,
-0.013488316,
0.015752971,
-0.010645874,
-0.002593396,
0.0021916023,
-0.016350681,
0.018436024,
0.04117556,
0.0009189787,
0.009065264,
-0.010420073,
-0.017957857,
0.021743352,
0.014026254,
-0.0110045,
0.018436024,
0.0031944264,
0.011097477,
-0.012166713,
0.021105794,
0.027282128,
0.0019591595,
-0.0043732426,
0.0064619062,
0.011907706,
-0.0022629953,
0.01563343,
0.007458089,
-0.0212519,
0.02778686,
-0.013760606,
0.013010148,
-0.04925128,
-0.012711293,
0.002522003,
-0.021145642,
0.010532973,
-0.014424727,
-0.0018811253,
0.0022895602,
-0.027919685,
0.019033734,
0.033763956,
-0.028849455,
0.008328089,
-0.008294882,
-0.018648542,
-0.025316328,
0.016815567,
-0.01492946,
-0.010997859,
-0.032993577,
0.004134159,
-0.0037954566,
0.015659995,
-0.008540608,
-0.023735717,
-0.008069081,
-0.022952054,
-0.019565031,
-0.03339205,
0.0029835675,
0.039262887,
-0.0065781274,
0.015806101,
-0.012033889,
0.004907861,
0.01879465,
-0.016350681,
-0.010944729,
0.0077436613,
0.017240604,
-0.012000683,
-0.018728238,
-0.006554883,
0.041892808,
0.017200757,
-0.017107781,
0.022912206,
0.0029719456,
0.021039382,
-0.027162585,
0.0068338146,
-0.008108929,
-0.015487323,
0.009603202,
-0.02527648,
0.05780517,
0.0016827189,
-0.03001831,
0.011050989,
-0.014504422,
-0.00082019053,
-0.13973124,
-0.011575645,
0.013787171,
-0.0037390064,
-0.008089005,
0.028636936,
0.012027248,
0.02664457,
-0.04346014,
0.018449306,
-0.015593583,
-0.0055952272,
-0.0010650855,
-0.0064917915,
0.0051801507,
0.008520684,
0.012903889,
0.019007169,
-0.04043174,
0.030204264,
0.018768085,
-0.0016702666,
-0.009530149,
-0.017851597,
0.003895075,
0.004821525,
-0.02887602,
0.035012506,
0.011688545,
0.020508084,
0.009297706,
-0.0015183487,
0.02898228,
0.0016412112,
-0.0081753405,
0.013335568,
-0.021769917,
-0.0012975282,
0.03498594,
-0.008148775,
-0.006053471,
0.0128574,
0.009483661,
0.007391677,
0.0192861,
-0.026272662,
-0.0025054,
-0.010200912,
0.019631444,
-0.02402793,
-0.016363963,
-0.024267014,
-0.056689445,
-0.0060368683,
0.010028241,
-0.035650063,
0.012359309,
0.014132514,
-0.0140793845,
0.0005628433,
0.013614499,
-0.015726406,
-0.01024076,
-0.0034003041,
0.032488845,
-0.0210261,
-0.0136012165,
-0.008952363,
0.01601862,
-0.041866247,
0.012206561,
-0.031851288,
-0.035968844,
-0.009038699,
-0.005425876,
0.011097477,
0.00806244,
-0.0195119,
0.0026531671,
-0.0050838534,
-0.009118394,
-0.012704652,
0.00043001893,
-0.0063324026,
0.008221829,
0.011429538,
0.012565186,
-0.0019591595,
-0.002767728,
-0.007803432,
-0.0005159397,
0.036207926,
-0.004492785,
-0.015102132,
-0.015806101,
0.0210261,
-0.0075112185,
-0.010791981,
0.03878472,
0.033870216,
-0.012419079,
0.0005466553,
-0.04869342,
0.026113274,
-0.026073426,
-0.013156255,
0.012804271,
-0.007989386,
-0.014743506,
-0.02255358,
0.018927474,
0.011170531,
-0.0014776712,
-0.010791981,
-0.027999379,
0.03328579,
-0.025608541,
0.011409614,
0.022527015,
0.0035596935,
0.02244732,
0.03246228,
0.007949539,
-0.021557396,
-0.0013174518,
0.022766098,
-0.004589082,
0.019485336,
-0.01765236,
0.026923502,
0.0018396176,
0.0008874329,
0.012253049,
-0.030363653,
-0.013521522,
0.005156907,
-0.009636409,
-0.008846104,
0.00871992,
0.014411446,
0.011628775,
0.04664792,
-0.01759923,
-0.023616174,
-0.007484654,
0.007013127,
-0.008135493,
0.00037128566,
-0.03193098,
0.008759768,
0.022673123,
-0.022699686,
0.028610371,
0.023270832,
-0.018701673,
-0.018529002,
-0.025595259,
0.0032126897,
0.0044197314,
-0.011462744,
-0.023138007,
0.0005371086,
0.02309816,
-0.004941067,
0.024386557,
0.008626943,
-0.0035065636,
-0.007916333,
-0.036978308,
0.021862892,
0.003164541,
0.019923657,
-0.019352512,
0.02130503,
-0.009171523,
0.0038386246,
0.0048547313,
0.0019840642,
-0.0120936595,
0.015327933,
0.008912516,
-0.014225491,
0.008148775,
-0.0063257613,
-0.005983738,
-0.0007458919,
0.033099834,
-0.0086535085,
0.0043167924,
0.025781212,
-0.005077212,
-0.0033488348,
0.0062460667,
0.01449114,
-0.0023825374,
0.0073186234,
0.0032807621,
0.016377246,
0.0040179375,
0.010798622,
0.00094388326,
0.03732365,
-0.0061796545,
-0.011562362,
0.015912361,
0.0021102473,
-0.015912361,
0.022115258,
-0.038253423,
-0.039953575,
-0.015819384,
0.009596561,
0.019352512,
0.012903889,
0.010811904,
-0.007856562,
-0.016802285,
0.00044496168,
0.013594575,
0.024931137,
-0.01596549,
0.022832511,
0.0118944235,
0.03105434,
0.0026764113,
-0.0057081277,
-0.0008156247,
0.013707476,
0.013488316,
-0.009071905,
0.018343046,
0.0039050367,
0.00061265245,
-0.027547777,
-0.022341061,
-0.003589579,
-0.008640226,
-0.016443659,
0.022673123,
0.018582132,
-0.0026946745,
0.061046086,
0.008188623,
-0.015447475,
-0.0004370752,
-0.020295566,
0.038147163,
0.012917171,
0.02691022,
-0.008241753,
-0.022194954,
0.0041607236,
-0.022101978,
0.02424045,
-0.038306553,
-0.03001831,
0.01612488,
-0.015673276,
-0.0014137495,
0.009576638,
-0.009144959,
0.008241753,
-0.0052764486,
0.020601062,
0.008978928,
-0.02037526,
-0.0037688918,
0.007099463,
-0.00039992592,
-0.009224653,
-0.030788692,
0.013720758,
0.016324116,
-0.039528538,
-0.023470068,
-0.0027195793,
-0.012804271,
-0.024386557,
-0.012624958,
-0.0030317164,
-0.0045857616,
-0.0030516402,
0.012797629,
-0.011954194,
-0.026285945,
0.0036460292,
-0.01999007,
-0.037164263,
-0.011482668,
-0.0065349597
] |
The Arabidopsis (Arabidopsis thaliana) trichome birefringence (tbr) mutant has severely reduced crystalline cellulose in trichomes, but the molecular nature of TBR was unknown. We determined TBR to belong to the plant-specific DUF231 domain gene family comprising 46 members of unknown function in Arabidopsis. The genes harbor another plant-specific domain, called the TBL domain, which contains a conserved GDSL motif known from some esterases/lipases. TBR and TBR-like3 (TBL3) are transcriptionally coordinated with primary and secondary | [
-0.025097938,
-0.0014267958,
-0.011687765,
-0.012159376,
-0.024264073,
0.02895285,
-0.016103143,
0.008495843,
-0.005553397,
-0.017005356,
-0.0057789506,
-0.011974833,
0.009404891,
0.025029588,
-0.015925433,
0.025357665,
0.013963804,
-0.0007035727,
-0.0034243101,
0.0026810092,
-0.022569006,
0.014558444,
-0.017634172,
0.0072177076,
-0.009616775,
0.0016848153,
0.026287219,
-0.026615296,
-0.029499644,
0.010026872,
0.0043709506,
0.0053141736,
-0.006370174,
-0.009562096,
-0.004623844,
-0.011250328,
0.0116946,
0.00062283484,
0.033846673,
-0.014093667,
0.024236733,
0.012849706,
-0.014038987,
0.0035268343,
-0.010628347,
-0.0036430284,
0.007470601,
0.011236658,
-0.010717202,
0.013143609,
-0.002349514,
0.033518597,
-0.014790832,
-0.011448542,
-0.015241939,
0.0033645043,
0.01792124,
0.02214524,
-0.008536853,
0.0038207371,
0.00757996,
-0.019206211,
-0.013902289,
0.00031099023,
-0.00818827,
0.01107262,
0.0013071842,
0.011222988,
-0.007149358,
-0.012877046,
0.034967605,
0.02054586,
0.011858638,
-0.024359763,
0.032206286,
-0.022733044,
-0.023744617,
0.0008291649,
-0.006086523,
0.0034721547,
-0.0032688149,
0.016991686,
-0.012583143,
0.012596813,
0.008817086,
0.011872308,
0.017265085,
0.00757996,
-0.0050612804,
-0.007306562,
0.012070522,
0.028597431,
0.013813434,
0.016882326,
-0.013642561,
-0.011687765,
-0.0007932814,
0.03037452,
-0.018057939,
-0.035295684,
-0.0031099024,
0.012699338,
0.0102455905,
-0.015747726,
-0.026957044,
0.003574679,
0.013410172,
0.0009167377,
0.0008817086,
-0.04707914,
-0.014886522,
0.029226247,
0.00587464,
-0.050059177,
0.019766675,
-0.022623686,
0.026054831,
-0.001901825,
-0.0047776303,
-0.010320775,
0.029144228,
0.03294446,
0.008571028,
-0.028296694,
0.03023782,
0.022883413,
-0.0034550673,
-0.0008731649,
0.00204365,
-0.010662522,
0.031878207,
0.011974833,
-0.0042342516,
0.003933514,
-0.006855455,
-0.007935377,
-0.028214674,
-0.017032696,
-0.010054212,
-0.025398675,
0.008133591,
0.036580652,
-0.039177936,
-0.006445358,
0.005854135,
0.02609584,
0.018208308,
0.024496462,
-0.0081746,
-0.007156193,
0.008277125,
-0.014134677,
0.025931802,
-0.002682718,
0.024892889,
0.020422831,
-0.003926679,
0.012699338,
-0.016677279,
0.01513258,
-0.0024879219,
-0.0046511837,
-0.0011482716,
-0.011387027,
0.03267106,
0.029800383,
-0.022514326,
0.0039369315,
0.0044837273,
-0.0063735913,
0.008755571,
0.008577863,
-0.022637356,
0.0051911445,
0.0027442325,
-0.0029544074,
0.009309202,
-0.0026570868,
-0.0111819785,
-0.008618873,
-0.017661512,
0.00026165045,
0.030620577,
0.00094236876,
-0.012815531,
-0.008447998,
0.022295607,
0.009855999,
0.007422756,
-0.025125276,
-0.017210405,
0.0137040755,
0.011844968,
-0.017757202,
-0.62903416,
-0.028542751,
0.014380735,
-0.0040086983,
0.010594173,
0.038221043,
0.0024007764,
0.0037387179,
-0.024004346,
0.002187184,
-0.005064698,
-0.008290795,
0.0146404635,
-0.014189357,
-0.015857084,
-0.038959216,
0.0015711841,
-0.018194638,
0.032589044,
0.009732969,
-0.012938561,
-0.004552077,
-0.016895996,
-0.0010876114,
0.0056422516,
0.016718289,
0.017962249,
-0.022733044,
-0.021448074,
0.0046853586,
-0.020860268,
0.030593237,
0.0062539796,
-0.00030757277,
0.051562864,
0.018563725,
-0.009691959,
0.009903843,
0.040681623,
0.038002323,
-0.0063735913,
-0.0005715727,
0.032534365,
-0.008372814,
-0.033381898,
0.033518597,
-0.0006181358,
0.015870754,
0.016854987,
-0.019903375,
-0.00050493196,
0.016075803,
-0.012829201,
0.0071835327,
0.02203588,
0.010799222,
0.018878132,
-0.003164582,
0.018550055,
-0.008878601,
-0.018003259,
0.03031984,
0.0062403097,
-0.007826018,
-0.014667803,
-0.015446988,
-0.022596346,
0.021584773,
0.012740348,
0.010108892,
-0.0009833785,
0.029663684,
-0.00588831,
0.015364968,
0.0020812424,
0.038767837,
0.024223063,
0.012179881,
0.0065581347,
0.03152279,
0.006048931,
-0.008208775,
-0.00044469896,
-0.018946482,
0.04117374,
0.0018300579,
-0.0059327367,
0.012596813,
-0.02476986,
-0.014613124,
0.014189357,
0.019452268,
-0.031905547,
-0.026710985,
-0.022186248,
0.014079997,
-0.017442793,
-0.00755262,
0.0032636886,
-0.010382289,
0.0027459413,
-0.027845588,
0.01520093,
0.0020880774,
0.0019753007,
-0.0063735913,
-0.01636287,
0.012296076,
0.03447549,
-0.008106251,
-0.019315569,
0.0001919126,
-0.014585784,
-0.011134134,
0.0016258638,
-0.020053744,
0.030538557,
-0.0060079214,
-0.0077986782,
-0.015310288,
-0.0031338248,
0.007614135,
0.0013618638,
-0.014462755,
0.028624771,
-0.0007133979,
0.0031697082,
-0.024113705,
-0.0015993784,
0.002096621,
0.014175687,
0.0077439984,
0.013478522,
-0.027162092,
0.018167298,
-0.0049348343,
0.012651493,
0.011469047,
-0.0062915715,
-0.028570091,
-0.011537396,
-0.021543764,
-0.000022360433,
-0.00031568928,
-0.018481705,
-0.020354481,
-0.0069101346,
0.02334819,
-0.003711378,
-0.0060831057,
0.010293435,
0.015556347,
-0.013512697,
0.000699728,
0.005242407,
-0.0108744055,
-0.025179956,
-0.028597431,
-0.007668814,
-0.0006604271,
0.019124191,
-0.0105463285,
-0.013205124,
-0.0092886975,
0.0047366205,
-0.009650949,
-0.005262912,
0.020040074,
-0.000607029,
-0.035405044,
-0.0043094363,
-0.03037452,
-0.016116813,
0.0036122713,
-0.022555336,
0.024223063,
-0.00587464,
0.0020556112,
-0.010683027,
-0.014257707,
-0.014626794,
0.020327142,
-0.009664619,
-0.03436613,
0.01515992,
0.012514794,
0.012931726,
0.028214674,
0.00615829,
0.026205199,
-0.0035507567,
0.006004504,
-0.010382289,
0.021543764,
-0.014667803,
-0.0032534364,
0.03272574,
0.0028433392,
-0.024619492,
0.013259804,
0.019042172,
-0.01173561,
0.027913937,
-0.037646905,
-0.002448621,
-0.026423918,
0.014476425,
-0.009726134,
0.0067085037,
0.0012234561,
0.0052321544,
-0.004237669,
-0.012760852,
0.0004733203,
-0.012248231,
0.01032761,
0.0028553004,
0.0022760385,
-0.004897242,
-0.007668814,
-0.020996967,
0.010566833,
0.025125276,
0.008776076,
-0.0051091253,
0.0067153387,
-0.0009944852,
-0.0066845813,
0.006100193,
-0.00055875716,
0.011421202,
0.00025097083,
0.012719843,
0.005573902,
-0.0030637665,
0.016212502,
0.02478353,
-0.005929319,
0.045493428,
-0.01168093,
0.0009415144,
0.038767837,
0.0014695143,
0.005372271,
0.014490095,
0.009069979,
0.025986481,
-0.011974833,
-0.008878601,
0.014312386,
-0.0069579794,
0.038166363,
-0.0030586403,
-0.006500038,
0.00058908726,
-0.0016344074,
0.012009008,
0.041665856,
0.04016217,
0.0031013587,
0.013656231,
0.01637654,
0.018864462,
-0.021174677,
0.015529007,
0.01633553,
-0.001709592,
-0.0048015527,
-0.012897551,
0.0002868543,
-0.010218251,
0.020286132,
0.0092955325,
-0.029362947,
0.0102455905,
0.007668814,
-0.013150444,
0.0040462906,
0.0017172813,
0.011195648,
-0.010088387,
-0.026628966,
0.027681548,
0.03740085,
-0.024113705,
-0.009794484,
0.008844426,
-0.013041086,
0.021407064,
0.019274559,
-0.0057584457,
0.0155836865,
0.024182053,
0.04426314,
0.0077713383,
-0.000049713584,
0.0011439997,
-0.036389276,
0.006824698,
-0.008133591,
-0.004063378,
-0.0054166983,
0.0014421745,
0.00039877664,
0.04243137,
-0.0031457858,
-0.015706716,
0.01664994,
-0.0011833007,
-0.025576385,
-0.009008464,
-0.0033833003,
-0.013225629,
-0.022951763,
0.0022709123,
0.00829763,
0.009145163,
0.016021123,
0.01663627,
0.006192465,
-0.022377627,
-0.025781432,
-0.006025009,
0.020108424,
0.02468784,
0.028542751,
-0.04013483,
0.014599454,
-0.005194562,
0.020381821,
-0.0024007764,
-0.028269354,
-0.0005600387,
-0.022637356,
-0.009213513,
-0.036033858,
0.014148347,
0.0030415528,
0.005977164,
0.017265085,
-0.0066128145,
-0.028242014,
0.00068819406,
0.020422831,
0.011079455,
0.0015489706,
0.00377631,
0.045356728,
0.028488073,
0.00293732,
0.013123104,
0.02474252,
0.0076209693,
0.004890407,
0.012104697,
-0.00016489318,
0.0027698637,
0.01788023,
0.0044256304,
-0.03447549,
0.019028502,
0.012836036,
-0.021366054,
-0.010115727,
0.012419105,
0.026396578,
0.003947184,
-0.012152541,
-0.019329239,
-0.021366054,
-0.013177784,
0.0017873395,
-0.018112618,
-0.009090484,
0.019807685,
-0.013375998,
-0.013362328,
-0.029581664,
0.018932812,
-0.0099311825,
0.0029065625,
0.0073339017,
0.00011982522,
-0.04420846,
0.0146404635,
-0.031331412,
0.011530561,
-0.0020949123,
-0.013560541,
0.0036225237,
-0.0063906787,
-0.02321149,
-0.007374911,
0.009650949,
-0.011263998,
-0.019151531,
-0.028214674,
0.009425396,
0.033709973,
0.0065786396,
0.009329707,
-0.009562096,
0.0014772037,
0.014462755,
-0.020791918,
-0.019165201,
0.018413356,
-0.024359763,
0.0020402328,
-0.002390524,
0.009322872,
-0.022787724,
-0.011885978,
0.02183083,
-0.0140116485,
-0.010293435,
0.030893976,
0.0021410482,
0.008106251,
0.0016361162,
0.03975207,
0.02464683,
-0.0047366205,
-0.0072518825,
0.0013968929,
-0.009336542,
-0.011263998,
-0.03458485,
0.009404891,
-0.01509157,
-0.013355493,
-0.0024400773,
-0.003926679,
-0.019821355,
0.0035405043,
0.0105394935,
0.009753474,
0.0023580578,
0.03157747,
0.012624153,
-0.025084268,
0.0034345626,
-0.008748736,
-0.014271376,
0.010915415,
-0.034065392,
0.023635259,
0.021092657,
-0.028159995,
0.026300889,
-0.005040776,
-0.019506948,
-0.0012576309,
0.009138329,
-0.009910678,
0.013369163,
0.0038378246,
-0.0038207371,
-0.014599454,
-0.013307648,
-0.00086632994,
0.009117824,
-0.0029902908,
-0.0064214356,
-0.022869743,
0.008776076,
0.017661512,
0.0034584848,
-0.025166286,
-0.02476986,
0.0064624455,
0.011339182,
-0.0046648537,
0.022240927,
-0.01506423,
0.0070058242,
-0.013102599,
-0.020463841,
-0.014517434,
-0.046231605,
-0.013635726,
-0.019561628,
0.044645894,
0.015501667,
0.019520618,
-0.003926679,
0.02217258,
0.03753755,
0.0051672226,
0.006018174,
-0.00042034945,
0.01500955,
-0.033682633,
0.010040542,
0.024072696,
-0.0051091253,
0.0178939,
-0.02322516,
0.018700425,
0.028132655,
-0.02058687,
-0.0026998054,
0.01179029,
-0.02870679,
-0.015734056,
-0.012091027,
-0.012022678,
0.005406446,
-0.0302925,
0.003933514,
0.028242014,
0.021352384,
-0.0022965432,
-0.010477979,
0.03849444,
-0.0118039595,
0.062061347,
0.0056012417,
0.033764653,
-0.035186324,
-0.029335607,
-0.002349514,
-0.02066889,
0.017333433,
-0.0070331637,
0.010724037,
0.0043231063,
-0.029909743,
0.00007513106,
0.017579492,
0.010013202,
-0.019014832,
0.005092038,
-0.0062539796,
-0.024605822,
-0.029882403,
-0.025426015,
-0.033491258,
0.015255609,
0.017183065,
-0.010525824,
0.024988579,
0.005645669,
-0.016089473,
0.012015843,
0.012364425,
0.056648068,
-0.007661979,
0.026451258,
0.02054586,
-0.021571103,
-0.022473317,
-0.015870754,
0.0063906787,
0.001589126,
0.04412644,
0.021202017,
-0.022828734,
-0.021174677,
0.02613685,
0.013444347,
-0.02876147,
-0.012760852,
-0.003960854,
-0.013608386,
0.018659415,
0.0057208533,
-0.0001040194,
-0.014449085,
0.015829746,
-0.025781432,
0.015980113,
-0.011311843,
-0.0058643874,
-0.013587881,
0.019588968,
-0.01788023,
0.007983222,
-0.016130483,
-0.0053346786,
0.011140969,
-0.017524812,
-0.0040189507,
0.0011474172,
0.0039676884,
0.03288978,
0.012918056,
-0.02330718,
0.0026212034,
-0.0013618638,
-0.012569473,
-0.017675182,
-0.011243493,
0.042376693,
-0.024961239,
-0.0061104456,
0.000027980577,
0.009753474,
0.01176295,
0.00890594,
-0.0029851645,
-0.003827572,
-0.015843416,
-0.0016514949,
0.018604735,
0.027093742,
0.00048656302,
0.020381821,
-0.020778248,
-0.019506948,
-0.0300191,
-0.03004644,
0.02188551,
-0.050031837,
-0.03012846,
0.015939103,
0.007149358,
0.03715479,
-0.011448542,
-0.0010312231,
-0.011906483,
0.028597431,
-0.031331412,
0.0022845822,
0.0022999607,
0.0026587956,
-0.044809934,
-0.00048869895,
-0.007614135,
-0.045958206,
0.009316037,
-0.052355718,
-0.011106794,
-0.0038993391,
-0.016950676,
-0.01781188,
0.009445901,
-0.030538557,
0.0051535526,
-0.02327984,
0.031112693,
0.000113951435,
-0.010320775,
-0.0043709506,
-0.015993783,
0.02471518,
0.008748736,
-0.017347103,
-0.015966443,
0.017606832,
-0.020737238,
-0.0042274166,
-0.005461125,
-0.016198833,
-0.019124191,
0.014107337,
-0.00580629,
0.0021666791,
0.009876503,
-0.0040394557,
-0.018809782,
0.0069169695,
-0.019958055,
-0.012234561,
-0.0032824848,
-0.0017958832,
-0.009022134,
-0.0010149901,
-0.028324034,
-0.0011585241,
-0.025343996,
-0.03026516,
-0.03964271,
0.006349669,
-0.011387027,
0.02471518,
-0.009008464,
-0.03453017,
-0.004524737,
-0.009193008,
-0.022486987,
-0.025029588,
0.00894695,
0.004258174,
-0.016718289,
-0.01027293,
0.0013789512,
0.032233626,
-0.016034793,
0.0072040376,
0.009172503,
-0.004285514,
0.00030137858,
-0.007306562,
0.025672073,
0.013000076,
-0.04699712,
-0.031331412,
0.028296694,
-0.018960152,
-0.004223999,
0.017688852,
-0.011961163,
0.033381898,
0.0025613976,
0.018823452,
-0.0072040376,
0.008352309,
0.018837122,
-0.008782911,
-0.009247688,
-0.014052657,
0.0024452035,
-0.015419648,
-0.00079199986,
-0.000050834944,
0.005194562,
0.022227257,
-0.02468784,
-0.02472885,
-0.0011833007,
-0.019342909,
0.012836036,
0.01506423,
-0.0012772813,
-0.009028969,
0.021502754,
0.0005557669,
-0.001526757,
-0.019917045,
-0.020887608,
-0.018700425,
0.0035883489,
-0.003079145,
0.014941202,
-0.015925433,
-0.023894986,
-0.022992773,
0.0009885047,
-0.01514625,
-0.0143397255,
-0.01515992,
0.009329707,
0.010266095,
-0.0235259,
-0.026984384,
-0.0034157664,
-0.012494289,
-0.0073680766,
0.012836036,
0.013451182,
-0.012494289,
-0.007279222,
-0.013211959,
-0.03291712,
0.0003391844,
-0.0047502904,
-0.006995572,
-0.0133965025,
-0.0062163873,
0.1854732,
-0.015392308,
0.010635182,
0.029362947,
-0.0015575143,
0.0028091646,
0.010115727,
-0.0025169705,
-0.033436578,
0.027831918,
0.0008436892,
0.008167765,
-0.030866636,
0.0022418636,
0.005652504,
-0.0018266405,
-0.018262988,
-0.0031816694,
-0.026574286,
0.016731959,
0.036525976,
-0.014189357,
-0.013574211,
-0.00588831,
0.05369537,
0.008830756,
-0.030702597,
-0.0096031055,
0.012091027,
-0.0047571254,
-0.0136904055,
-0.02471518,
-0.0068486203,
0.004422213,
0.022664696,
-0.000014604367,
0.0031150286,
-0.0023939414,
0.012241396,
0.010525824,
-0.002590446,
0.009828659,
0.010573668,
-0.0018044269,
-0.005027106,
0.0049074944,
0.00832497,
0.0008646212,
-0.01163992,
0.013410172,
-0.028242014,
0.025398675,
0.017196735,
0.040955022,
0.005085203,
-0.020272462,
0.012986406,
0.013109434,
0.0041317274,
0.02330718,
-0.02892551,
0.026246209,
-0.029308267,
0.02898019,
-0.017579492,
0.01654058,
-0.029335607,
0.00759363,
0.026382908,
-0.013854444,
-0.013731415,
-0.019917045,
-0.011243493,
0.015693046,
-0.002812582,
-0.012856541,
0.009630444,
0.010108892,
0.026519608,
0.02195386,
0.005064698,
-0.015966443,
-0.040982362,
-0.0043709506,
-0.00027553394,
-0.016923336,
0.028050635,
0.0006506018,
0.010252425,
-0.02187184,
0.008406989,
-0.0072382125,
-0.0064077657,
-0.006127533,
0.019301899,
-0.009705629,
0.005502135,
-0.008953785,
-0.013512697,
-0.018659415,
-0.024947569,
0.045630127,
-0.005949824,
0.017073706,
-0.028050635,
0.019889705,
0.0012097862,
-0.012617318,
0.024961239,
-0.0010961551,
0.008489008,
-0.01660893,
0.00097227166,
0.0040257857,
0.008823921,
0.007436426,
0.022760384,
-0.037865624,
0.019985395,
-0.009808154,
0.0038173196,
-0.013929629,
-0.0011918445,
0.03669001,
-0.011469047,
0.006243727,
-0.016950676,
0.014367065,
-0.006294989,
-0.0435523,
0.0026006985,
0.008393319,
0.021434404,
0.010266095,
0.0038309896,
0.005040776,
0.009903843,
-0.0054918826,
-0.038603798,
0.023935996,
-0.014941202,
-0.020450171,
0.016253512,
-0.012938561,
-0.02053219,
-0.025931802,
0.012849706,
0.0057003484,
-0.024045356,
-0.006424853,
-0.0009944852,
-0.019329239,
-0.027777238,
-0.016690949,
0.021707801,
-0.008735066,
-0.019684657,
-0.016116813,
0.018016929,
0.012261901,
-0.02355324,
0.008926445,
0.014271376,
-0.007846523,
0.01514625,
0.015570017,
-0.1742092,
0.02889817,
0.026765665,
-0.01655425,
0.022418637,
0.0056627565,
0.015310288,
0.002891184,
0.003834407,
0.005659339,
0.031987567,
0.018932812,
-0.02742182,
-0.028378714,
-0.011557901,
-0.0009218639,
-0.017019026,
0.038795177,
0.012063688,
0.009527921,
0.0021393395,
-0.0077918433,
0.009377552,
0.0047913003,
0.009780814,
0.02195386,
0.034967605,
-0.012808696,
-0.00025588344,
-0.020901278,
-0.009644114,
0.007812348,
0.032425005,
-0.02898019,
0.02742182,
-0.008010562,
-0.024564812,
0.0026946792,
0.0048869895,
0.0060523483,
0.0021923103,
0.011011105,
-0.0035815139,
-0.012255066,
-0.027408151,
0.029636344,
-0.0017360774,
-0.004610174,
0.011981668,
-0.016759299,
0.01792124,
-0.0026998054,
0.021311374,
0.020231454,
0.032151606,
0.0036772033,
-0.0034448148,
0.023061123,
-0.012466949,
-0.02183083,
-0.020860268,
-0.004251339,
0.02900753,
-0.0083113,
-0.0025152618,
-0.023033783,
-0.006674329,
-0.0092886975,
-0.020217784,
0.01785289,
-0.021543764,
-0.0077781733,
0.005799455,
-0.015898094,
0.000035883488,
0.029362947,
-0.014148347,
-0.007696154,
-0.009938017,
-0.012637823,
-0.032561705,
0.027121082,
-0.036416616,
-0.011325513,
-0.00832497,
0.017688852,
-0.006445358,
0.031167373,
-0.009083649,
-0.0012217474,
0.021543764,
-0.03409273,
0.019260889,
-0.027995957,
0.030620577,
0.028159995,
-0.009452736,
0.0010431843,
0.0031355335,
0.0011730484,
0.01373825,
-0.006404348,
-0.020846598,
0.021065317,
0.010307105,
0.009124659,
-0.023006443,
-0.0035575917,
0.056046594,
-0.00044811642,
0.002961242,
-0.019780345,
0.01513258,
0.033600617,
-0.011769785,
0.019958055,
0.0073202318,
0.00013103882,
0.022213588,
-0.03704543,
0.05317591,
0.019028502,
-0.0063325814,
0.0012730095,
-0.017374443,
-0.01510524,
-0.12149808,
-0.006582057,
-1.668689e-7,
0.007286057,
-0.017005356,
0.000794563,
-0.018044269,
0.02194019,
-0.015487997,
0.035213664,
-0.014941202,
-0.019356579,
-0.009069979,
-0.016937006,
0.009548426,
0.021174677,
-0.0027630287,
0.0010970095,
-0.024250403,
0.02870679,
-0.006975067,
-0.008858096,
0.02061421,
-0.016048463,
0.020108424,
-0.0069853193,
-0.038986556,
0.016759299,
0.003796815,
0.014531104,
-0.018071609,
-0.01664994,
0.03302648,
-0.0033098247,
-0.016198833,
-0.018180968,
0.018987492,
-0.020176774,
0.020450171,
-0.010279765,
-0.012719843,
0.0060147564,
0.003947184,
-0.012193551,
0.008776076,
-0.012938561,
0.010389124,
0.0069511444,
0.014435415,
-0.015487997,
-0.029226247,
-0.027080072,
-0.022678364,
-0.012029513,
0.025726752,
-0.00755262,
0.023853976,
0.022856073,
-0.011414367,
-0.007839688,
-0.007737164,
0.0012473784,
0.001341359,
0.007880698,
0.025631063,
-0.015652036,
-0.019397588,
-0.029745704,
0.027121082,
-0.018659415,
0.00089623284,
0.0076209693,
-0.013020581,
-0.0055636493,
-0.016978016,
0.0044632223,
-0.05489832,
-0.011352852,
-0.0034089314,
-0.040654283,
0.00087231054,
-0.013492192,
0.029171567,
-0.025220966,
0.0009714173,
0.0067290086,
-0.016116813,
-0.0057516107,
0.025234636,
-0.03045654,
-0.021078987,
0.036334597,
-0.0065102903,
-0.028159995,
-0.013956969,
0.018768774,
0.027995957,
0.0070331637,
0.02464683,
0.007737164,
-0.040927682,
-0.035076965,
-0.06381109,
0.029144228,
0.0015848541,
-0.0023939414,
0.013574211,
0.011988503,
0.03037452,
0.019397588,
-0.004531572,
0.014038987,
-0.011783455,
-0.0023290094,
-0.0021923103,
-0.027818248,
-0.025002249,
-0.040435567,
0.0494577,
-0.0054645427,
0.034776226,
0.033600617,
0.00289631,
-0.0072108726,
0.018932812,
0.012193551,
-0.027408151,
-0.012378095,
-0.025002249,
0.0034208926,
-0.0221179,
0.0064077657,
0.0068520377,
-0.02481087,
-0.021694133,
-0.003725048,
-0.009616775,
-0.0047502904,
-0.020750908,
0.034065392,
0.015870754,
0.009876503,
-0.02195386,
-0.05079735,
0.02353957,
0.014312386,
0.0025426014,
-0.0077645034,
-0.06457661,
0.011168309,
0.013464852,
0.009404891,
0.020764578,
0.016075803,
0.017101046,
-0.011462212,
-0.0127471825,
-0.016800309,
-0.002474252,
-0.023607919,
0.008598368,
-0.02900753,
0.026697315,
0.027271451,
0.016813979,
-0.0045008147,
-0.0015515337,
-0.0043094363,
-0.024004346,
-0.013191454,
0.0023102132,
-0.041775215,
-0.013820269,
0.00825662,
0.019944385,
0.020231454,
0.0036225237,
0.009828659,
-0.030620577,
0.00069161155,
-0.023758287,
0.032507025,
0.0048083877,
-0.017224075,
-0.020395491,
0.01166726,
0.018837122,
-0.023799296,
-0.008489008,
0.005840465,
0.014066327,
-0.0021906015,
0.012186716,
0.025289316,
-0.0038173196,
0.0118107945,
-0.0017668346,
0.015788736,
0.00082275714,
-0.019944385,
-0.0057652807,
0.022828734,
-0.022186248,
0.003827572,
0.012487454,
-0.026068501,
-0.0102387555,
0.025795102,
-0.019014832,
-0.019725667,
-0.003947184,
-0.0048391446,
-0.0010184076,
-0.0058575524,
-0.0013071842,
0.0024178636,
-0.0017907569,
0.021571103,
-0.009903843,
0.008475338,
-0.0068417853,
0.017620502,
0.018139958,
0.026533278,
0.013567376,
0.010033707,
0.019192541,
0.027995957,
0.03433879,
-0.014845512,
0.014572114,
-0.010443804,
0.004883572,
0.006025009,
-0.0035029121,
-0.013129939,
0.012706173,
0.0069238045,
0.00040454362,
0.024879219,
-0.013000076,
0.086885884,
0.021666793,
0.010156736,
-0.006739261,
-0.024250403,
0.027326131,
0.006940892,
0.019438598,
-0.006165125,
-0.022842404,
0.007306562,
0.00081976684,
0.01782555,
-0.011892813,
-0.038822517,
0.02881615,
-0.013745085,
0.004077048,
-0.018262988,
-0.033545937,
0.014913862,
-0.023662597,
0.013150444,
0.03034718,
-0.020381821,
-0.01502322,
0.0124396095,
0.002812582,
0.0010833396,
-0.006301824,
0.008598368,
-0.024605822,
-0.032206286,
-0.014804502,
0.019930715,
-0.0056559215,
-0.020983297,
-0.013929629,
0.024236733,
0.016827647,
-0.0024503297,
0.0053415135,
-0.013608386,
-0.007928542,
0.0039813584,
-0.0068862126,
-0.01170827,
-0.027941277,
-0.002974912
] |
Taxanes have resulted in improved survival for breast cancer patients, but often cause neurological toxicities. Identification of biomarkers related to toxicities could be important for dictating treatment regimen. We evaluated single nucleotide polymorphisms (SNPs) in the Fanconi Anemia (FA)/BRCA pathway in relation to grade 3/4 neurotoxicities in patients (n = 888) from SWOG0221, a phase III adjuvant trial for breast cancer of 4 dose/schedules of cyclophosphamide (C), doxorubicin (A), and paclitaxel (T). In | [
-0.017350052,
-0.0015804599,
0.009474221,
-0.03806082,
-0.021858333,
0.034645457,
-0.024262749,
-0.0004777241,
-0.014972957,
-0.007978291,
0.02989127,
0.007950968,
0.024986805,
0.0042896974,
-0.0048054177,
-0.00081968744,
0.02915355,
0.008640871,
-0.0019211425,
-0.007950968,
-0.028661737,
0.043224853,
-0.002923552,
0.002235356,
0.014098624,
0.008470103,
-0.0012602694,
-0.044946194,
-0.012384111,
-0.0136682885,
0.019522222,
0.0028928136,
-0.018470291,
-0.006028118,
0.00088884856,
0.009282961,
0.004344343,
-0.0088799475,
0.003674932,
-0.010075325,
0.002348063,
0.011666885,
0.009849911,
0.018893795,
-0.025492279,
-0.02213156,
0.013005707,
-0.014522129,
-0.011789838,
0.011742023,
0.0043067746,
0.0015215448,
-0.012848601,
-0.014166932,
-0.012916908,
-0.02155778,
0.021120613,
0.02006868,
-0.0027425375,
-0.0058812574,
-0.011359502,
0.017199775,
-0.025260035,
0.035109945,
-0.019959388,
0.008873116,
0.027732758,
0.013518012,
-0.010239262,
0.0009665481,
0.025328342,
0.025055112,
-0.020082342,
-0.001622298,
0.02418078,
-0.019617852,
-0.041476186,
0.0010818166,
0.0066155605,
0.015218863,
0.031995133,
-0.015888276,
-0.011680546,
0.0029559978,
0.019112378,
-0.001284177,
-0.015027603,
0.0044297273,
-0.004040376,
0.0009904556,
0.03046505,
0.0028296295,
0.0001845364,
-0.006496023,
0.002815968,
0.02745953,
0.004928371,
0.014221577,
0.011578085,
-0.019153364,
0.0033504723,
0.013319921,
-0.011571255,
-0.008422288,
-0.024194442,
0.0023822165,
-0.00684439,
0.02203593,
0.011482455,
0.0022524328,
-0.011270702,
0.030956862,
0.0062091323,
-0.030109853,
0.026393935,
-0.017391035,
0.030355759,
-0.002127772,
-0.014481145,
-0.021598764,
0.032650884,
0.013333582,
0.006028118,
-0.021038644,
0.0117147,
-0.008729671,
-0.028005987,
-0.013306259,
-0.008982408,
-0.009037054,
-0.0019945728,
0.002535908,
0.035629082,
-0.005512398,
-0.018989425,
-0.0011398778,
-0.03573837,
-0.027391221,
-0.034563486,
-0.033798445,
0.017473005,
0.04153083,
-0.018483952,
-0.013750257,
-0.01359315,
0.026708148,
0.03355254,
0.018238045,
0.009337606,
-0.018497612,
-0.0056660892,
-0.01097015,
-0.0009042177,
0.00012508772,
-0.012896416,
0.029590717,
-0.00036459015,
0.020560494,
-0.022473097,
-0.023606999,
-0.0045048655,
-0.0011894007,
0.004610742,
-0.002305371,
0.009050716,
0.016462056,
0.0012628309,
-0.00712445,
0.0038901,
-0.0219403,
0.0168719,
0.019535884,
-0.007349864,
0.019003088,
0.0016675516,
0.009979694,
-0.005580705,
0.0101777855,
-0.0031609198,
-0.019891081,
0.011926453,
0.013845887,
0.03273285,
-0.014112285,
-0.02090203,
-0.00018837869,
0.024918498,
-0.01594292,
-0.012438757,
-0.019194348,
-0.002863783,
0.009064377,
-0.010068494,
-0.021106951,
-0.6343288,
-0.004057453,
-0.003722747,
-0.01912604,
0.018374661,
0.02427641,
0.019071395,
0.0006109233,
-0.020983998,
0.014863665,
-0.011352671,
0.026298305,
0.02868906,
-0.018115092,
-0.02155778,
-0.02830654,
0.0033470572,
-0.019344624,
0.049727704,
-0.00702882,
-0.022609713,
0.023197155,
-0.010731075,
0.009877234,
0.017800879,
-0.0031626273,
0.02127089,
-0.021858333,
0.0015992443,
0.018948441,
-0.030301113,
0.022281837,
0.011175072,
0.010191447,
0.045328714,
-0.014412837,
-0.004385328,
0.025888462,
0.0134565355,
0.011926453,
-0.029754654,
-0.006352578,
0.016393749,
-0.017691588,
-0.020273603,
0.036749322,
-0.004422897,
0.006571161,
0.0041325907,
-0.014604098,
0.017131468,
0.025342003,
-0.03046505,
0.010519322,
0.021079628,
0.016106859,
0.026025075,
-0.020300925,
0.005679751,
0.007773369,
-0.014358192,
-0.002175587,
0.0015445985,
-0.026243659,
0.0011091395,
0.004023299,
-0.025683539,
0.019016748,
0.005744643,
-0.032760173,
0.025082435,
0.030792926,
-0.0061988863,
-0.0056080283,
0.032268364,
0.026503228,
0.01321746,
0.016434733,
-0.032568913,
0.018921118,
0.0057685506,
-0.007527463,
-0.049673058,
0.008401796,
0.03964555,
-0.0022541406,
-0.018142415,
0.023757275,
0.004764433,
-0.0020014036,
-0.0058231964,
0.014030317,
0.0053177224,
-0.032842144,
-0.015601384,
-0.0035827172,
0.018046785,
0.000009412264,
-0.014194254,
-0.045219425,
-0.027227284,
-0.0004303359,
-0.0065609147,
-0.02006868,
0.0027749834,
0.006311593,
-0.0086203795,
0.019904744,
0.0219403,
-0.020232618,
-0.014084962,
0.0064140544,
0.002278048,
-0.026134368,
0.0010579091,
-0.023374753,
0.0051811077,
0.017268082,
-0.03497333,
-0.031011509,
0.01762328,
0.030601665,
-0.0008239566,
0.0005114508,
0.015492093,
-0.0050000935,
-0.00026618497,
-0.019153364,
0.0123704495,
-0.03000056,
0.007814353,
-0.012718817,
0.006957097,
-0.013470197,
0.009241976,
-0.01603855,
0.000972525,
-0.0077802,
-0.0027271684,
-0.013989332,
-0.020314587,
-0.01228165,
-0.009665481,
0.009884064,
-0.011742023,
0.004299944,
-0.040820435,
0.011584916,
-0.0014190839,
0.019071395,
0.0056558433,
0.0059222416,
-0.007773369,
0.02953607,
0.04199532,
-0.005222092,
0.01069009,
-0.024877515,
-0.0046073264,
-0.012541218,
-0.0057958732,
-0.0054065217,
0.00017706529,
-0.015410124,
-0.026489565,
-0.026858425,
0.011195565,
0.0298093,
0.020861045,
-0.040437914,
-0.015396463,
-0.038771216,
-0.01959053,
0.012882754,
-0.013087676,
0.0036476091,
-0.0019126041,
-0.00018016047,
0.0024471085,
-0.009972864,
0.0000278032,
-0.023962196,
-0.015901936,
-0.0027254608,
0.04855282,
0.02248676,
0.032104425,
0.00731571,
-0.011277533,
0.022732666,
-0.02334743,
0.005710489,
-0.0018664966,
-0.003019182,
0.0018716196,
-0.010806213,
0.0039549917,
0.014727051,
-0.00722008,
0.023183493,
0.02174904,
-0.0030772432,
0.039235704,
0.000104488805,
0.007725554,
-0.017104145,
0.006205717,
-0.005894919,
0.005744643,
0.007773369,
-0.0012474618,
0.008408627,
-0.015478431,
-0.003336811,
-0.010369047,
0.0028347524,
0.0038696078,
-0.009037054,
0.01677627,
-0.009925049,
-0.0020987415,
-0.002325863,
0.020478524,
0.005775381,
0.0041360063,
0.013231121,
0.0124182645,
0.012582202,
0.014890988,
-0.020314587,
0.0036885934,
0.0122065125,
-0.0028023066,
0.0129852155,
0.01209039,
0.0012192851,
-0.004750772,
-0.0053006453,
0.04743258,
-0.012930569,
-0.014385515,
0.001907481,
0.009248806,
-0.00082139514,
0.02756882,
0.0045526805,
0.008026106,
0.018347338,
-0.0046073264,
0.013231121,
-0.0065745763,
-0.011284363,
-0.021407504,
-0.0057378123,
0.01771891,
-0.03459081,
0.004518527,
0.052897163,
0.03347057,
0.021393843,
0.047569193,
-0.0051059695,
0.0051025543,
-0.0049147094,
-0.0007833992,
0.007991953,
0.015628707,
-0.00026895994,
0.0074591557,
-0.0020082342,
-0.026557874,
-0.021120613,
0.015956583,
-0.017391035,
0.0054884907,
-0.0059188264,
-0.0069775893,
0.029126227,
0.010246093,
0.010334892,
-0.003261673,
-0.030902216,
0.031202769,
0.027240945,
-0.008374473,
-0.012104051,
-0.010184617,
0.019235332,
0.014467483,
0.015437447,
0.018019462,
0.009522036,
-0.01536914,
-0.004480958,
-0.0003470864,
-0.0078894915,
-0.0014600683,
-0.015437447,
-0.0055055674,
-0.009549359,
0.016352765,
-0.006523346,
0.0046858797,
-0.0066702063,
0.017473005,
-0.0059290724,
-0.023497706,
-0.02699504,
-0.018251708,
-0.01903041,
0.0066053146,
-0.033716477,
-0.0126300175,
-0.008449611,
-0.004562927,
0.00006387799,
0.007677739,
-0.00562169,
0.0232518,
-0.0026622766,
-0.0081968745,
-0.0311208,
0.01144147,
0.013757087,
0.028388508,
0.013354074,
-0.008900439,
0.0064072236,
0.015683353,
0.011673715,
0.0000063671196,
0.009009731,
0.029563393,
-0.009364929,
-0.012575371,
0.0052357535,
0.0120630665,
0.01546477,
0.0069878353,
0.04013736,
0.000220291,
-0.031257413,
-0.0058368575,
0.0004657703,
-0.008005614,
-0.025820155,
0.032760173,
0.010772059,
0.01527351,
0.010990642,
0.009453729,
0.023770936,
0.015259848,
-0.013647796,
-0.0036646859,
-0.0041667446,
-0.01565603,
0.03516459,
0.0116259,
-0.007547955,
0.034754746,
0.02267802,
-0.0024624777,
0.00081627205,
0.033716477,
-0.014754374,
0.019699821,
0.012308973,
0.021079628,
-0.009440067,
0.007636755,
-0.0031711657,
0.0061169174,
-0.008169551,
0.025369326,
-0.012022083,
-0.013470197,
-0.008190043,
0.008886778,
-0.0025905538,
-0.010676429,
-0.011420978,
0.009638159,
0.0046824645,
0.010819874,
-0.0034409796,
0.012425096,
0.00009370906,
-0.024918498,
-0.009959202,
-0.029180873,
-0.007090296,
-0.015505754,
-0.03513727,
-0.0016718209,
-0.023128847,
-0.019399269,
0.008654533,
0.02765079,
0.013449705,
0.0245633,
-0.0052733226,
-0.019508561,
0.045082808,
-0.003599794,
-0.011222887,
0.0002890252,
-0.0311208,
0.010020679,
0.005116216,
-0.009685974,
-0.008955086,
-0.034153644,
0.020970337,
0.025314681,
-0.012329466,
0.007978291,
0.008087583,
0.008852624,
0.02203593,
0.029454103,
0.03177655,
-0.0007031381,
-0.008108075,
0.02315617,
-0.029508747,
-0.014645082,
-0.025902122,
-0.010102647,
-0.0138800405,
-0.009590343,
-0.009023393,
0.005625105,
-0.0012047698,
-0.0002326717,
-0.020560494,
-0.013142322,
-0.0015608215,
0.014686067,
0.020697108,
-0.004651726,
0.019768128,
-0.0027869374,
-0.0021260644,
-0.00032104424,
0.0022473098,
0.027924018,
-0.0019740807,
-0.021052307,
0.007903153,
-0.0065745763,
-0.008797979,
-0.021161597,
0.009808926,
0.0072337417,
0.03092954,
0.008019275,
-0.01612052,
-0.010580799,
-0.0038354541,
-0.010649106,
-0.0018818658,
-0.0023463552,
-0.014890988,
-0.0031250583,
0.0064926078,
0.018401982,
-0.024768222,
0.009282961,
-0.029781977,
-0.011420978,
0.012349958,
-0.010116309,
0.00768457,
-0.023729952,
-0.0014224992,
-0.0025649385,
-0.012800786,
-0.033771124,
-0.020218957,
0.00609301,
0.003702255,
0.028798353,
0.03215907,
0.022145223,
-0.011229718,
0.0013729765,
0.03262356,
-0.0018852811,
0.016434733,
-0.020164311,
0.023579676,
-0.0033197342,
0.03404435,
0.009610835,
0.008627211,
-0.0028142603,
-0.007930476,
0.032295685,
0.031394027,
-0.01106578,
-0.03065631,
-0.013449705,
-0.052132122,
-0.029508747,
0.030109853,
-0.014522129,
0.027254608,
-0.034481518,
0.014385515,
0.015860952,
0.020369234,
-0.004583419,
-0.026421258,
0.028169924,
-0.00006307751,
-0.005174277,
-0.013128661,
0.007356695,
-0.022432113,
-0.03825208,
0.009979694,
-0.017759895,
-0.007896323,
-0.005894919,
0.01509591,
0.030301113,
-0.0071449424,
0.013155984,
0.017336389,
-0.02953607,
-0.025246372,
-0.018866472,
-0.03166726,
-0.0043101897,
-0.012384111,
-0.015232525,
-0.03008253,
-0.010362215,
0.001267954,
-0.015164218,
0.013791241,
-0.0012201389,
-0.023497706,
0.011537101,
-0.005351876,
0.0011646393,
-0.018374661,
0.03273285,
-0.0050035086,
-0.015860952,
-0.015314493,
-0.019481238,
0.0034529334,
-0.0020423878,
0.03169458,
0.04021933,
-0.01088135,
-0.0056934124,
0.010334892,
0.008661364,
-0.031476,
-0.031995133,
0.02970001,
-0.00029244059,
0.026393935,
-0.016926546,
-0.008914101,
-0.03945429,
0.046257693,
0.012356788,
-0.004330682,
0.015218863,
-0.0337438,
-0.0134565355,
0.0020970337,
-0.011311687,
0.00731571,
-0.017500326,
-0.018962102,
-0.0072132493,
-0.0016462057,
0.022186207,
0.0042316364,
-0.03423561,
0.046339665,
0.010088986,
0.0023087864,
0.005652428,
0.011079442,
0.0045902496,
-0.004798587,
0.009317114,
0.044536352,
-0.0025666463,
0.008183213,
0.022555066,
-0.002971367,
-0.013381397,
0.008019275,
-0.006861467,
-0.011099934,
-0.039973423,
0.005099139,
0.013825395,
0.0053382143,
-0.019631514,
0.012151866,
-0.030437727,
-0.0066394685,
-0.015888276,
-0.037323102,
0.01453579,
-0.052432675,
-0.015765322,
-0.00478151,
0.011660053,
0.022199867,
0.019153364,
-0.008067091,
-0.011830822,
0.02970001,
0.0045936652,
-0.000009999279,
0.024303732,
0.013770749,
-0.03497333,
0.00004085096,
-0.02907158,
-0.008982408,
-0.0040984373,
-0.022336483,
-0.031394027,
-0.026189014,
-0.003218981,
0.008593056,
0.026257321,
-0.039317675,
0.030765602,
0.003471718,
0.008408627,
-0.027596144,
-0.035109945,
0.00068478053,
-0.028661737,
0.02907158,
0.020218957,
-0.0031301815,
-0.024331056,
-0.02362066,
0.0007944991,
-0.016229812,
-0.0018869888,
-0.011038458,
0.0021124028,
0.0076435856,
0.009583512,
-0.0025666463,
0.01592926,
-0.0208064,
-0.02934481,
0.030328436,
0.020574154,
-0.0124182645,
0.006164733,
0.017951155,
0.0072474033,
0.025191728,
-0.03401703,
-0.016065873,
-0.006120333,
-0.013244783,
-0.0399461,
-0.00061860785,
0.0024419855,
0.020669784,
0.017814541,
-0.010416862,
-0.01461776,
-0.021038644,
-0.015505754,
-0.021626087,
-0.015601384,
0.010485169,
0.005980303,
0.022008607,
-0.018019462,
0.0033607185,
-0.0057412274,
0.0048327404,
0.0012816155,
0.0067829136,
0.008237859,
-0.013900532,
0.026708148,
0.0057856273,
-0.036230184,
0.008162721,
0.038853183,
0.0038115466,
-0.02278731,
0.0135726575,
-0.013114999,
0.0027442453,
-0.03404435,
0.0061886404,
-0.01631178,
0.011940113,
0.025082435,
-0.019044071,
0.00029692324,
-0.0021141106,
0.0047576027,
-0.0012483157,
0.017773556,
0.006909282,
0.015997566,
-0.0010980397,
-0.02005502,
-0.024481332,
0.006905867,
0.0032821652,
-0.0023019556,
0.04866211,
0.011482455,
0.020888368,
-0.0031199353,
-0.008463273,
-0.005502152,
-0.020287264,
-0.006038364,
0.0012389234,
0.0042589596,
-0.00068478053,
-0.006994666,
0.007021989,
0.008756994,
-0.00815589,
-0.005983718,
0.0028825675,
-0.026025075,
-0.038552634,
0.016434733,
-0.019412931,
-0.018757181,
-0.028798353,
0.0012098928,
-0.04461832,
-0.0052835685,
-0.0245633,
0.007869,
-0.033033404,
0.019057732,
-0.010737905,
-0.027077008,
-0.005946149,
-0.010621783,
-0.019371947,
-0.020642461,
0.0069605126,
0.17967549,
-0.0064550387,
-0.0044468045,
0.021885654,
0.02915355,
-0.006291101,
0.0284978,
0.008497426,
-0.0078894915,
0.001735859,
0.03308805,
-0.005256246,
-0.0051401234,
-0.0029559978,
0.012022083,
-0.0011646393,
-0.028934967,
-0.025738185,
-0.019289978,
-0.01331309,
-0.0005353584,
0.0012005005,
0.0045424346,
0.0011031626,
0.010184617,
0.0075616166,
-0.021858333,
-0.007493309,
0.014686067,
-0.0074864784,
-0.025738185,
0.0045936652,
0.009877234,
-0.0028040141,
-0.0034580564,
-0.011844483,
-0.005744643,
-0.008634041,
-0.0081490595,
0.017705249,
-0.015437447,
0.023183493,
-0.032514267,
-0.007131281,
-0.019549545,
0.0059598107,
-0.018825488,
-0.015546738,
-0.01509591,
0.001875035,
-0.045219425,
0.02082006,
0.015109572,
0.0036032093,
0.008237859,
0.0046346495,
0.03494601,
-0.004077945,
-0.0034853793,
0.039153736,
-0.0051332926,
0.0010135093,
-0.021024983,
0.025314681,
-0.0046824645,
0.0032104424,
-0.020792738,
-0.0013874917,
0.02314251,
0.002583723,
-0.0030328436,
-0.00946739,
-0.022896603,
0.011359502,
-0.004802002,
-0.023128847,
0.017554972,
0.0055089826,
0.0123704495,
0.016434733,
0.0023617244,
0.0009409329,
-0.02314251,
0.018074108,
-0.028060634,
-0.045902498,
0.0111204265,
-0.0068307286,
-0.003992561,
0.014672405,
0.0115917465,
-0.006458454,
-0.018101431,
0.012179189,
0.001015217,
0.015697014,
0.0015078833,
0.027240945,
-0.020943014,
-0.017199775,
-0.04265107,
0.08235127,
-0.009788434,
0.024071489,
-0.005765135,
0.010300739,
-0.004050622,
0.019003088,
0.007356695,
0.0038183774,
-0.002713507,
-0.009105361,
-0.010847197,
-0.026872087,
0.014686067,
0.012718817,
-0.008490596,
-0.03254159,
0.018948441,
-0.019850098,
0.013074014,
-0.027049685,
0.008975578,
0.025533265,
-0.007862168,
0.0063901464,
-0.026216337,
-0.02989127,
-0.0025786,
-0.019167025,
0.0022968326,
-0.005727566,
-0.010935997,
-0.016202489,
-0.012445588,
-0.013162814,
-0.0050410777,
-0.007179096,
-0.008756994,
0.031530645,
0.004614157,
-0.00018464314,
-0.007677739,
0.012855431,
-0.00417016,
-0.014850005,
0.020410217,
-0.006318424,
-0.016011229,
-0.009979694,
-0.012746139,
-0.014781697,
-0.012172358,
0.0045116963,
0.024030503,
-0.030301113,
-0.022910263,
-0.044345092,
0.004358005,
0.028989613,
-0.040000748,
0.010273416,
0.045082808,
-0.005915411,
-0.005549967,
0.0113799935,
-0.17432019,
0.031940486,
0.027008701,
-0.026421258,
0.04407186,
0.008688686,
0.023456722,
-0.021120613,
-0.00141823,
-0.00403013,
0.031557966,
0.01997305,
-0.020177972,
-0.01575166,
0.0013345536,
0.009863572,
-0.0065028537,
0.052104797,
0.026366612,
0.011414148,
0.0017042668,
-0.018265368,
0.0129852155,
-0.024809206,
-0.008026106,
0.008545241,
-0.0029252595,
-0.003722747,
0.0007727262,
0.013114999,
-0.012602694,
-0.0070561427,
0.008046598,
-0.011762515,
0.024030503,
0.025082435,
-0.016298119,
-0.008572564,
-0.006946851,
0.018852811,
0.017609619,
0.035956956,
0.024590623,
-0.01461776,
-0.018470291,
0.010273416,
0.017186113,
-0.013845887,
0.008087583,
0.006974174,
0.009856742,
-0.007752877,
0.019672498,
-0.004576588,
0.00062928087,
0.0070356503,
0.007506971,
0.01059446,
0.02267802,
-0.003797885,
0.001644498,
-0.027036024,
0.011694208,
0.006028118,
0.0009887479,
-0.028142601,
-0.023074202,
-0.009487882,
-0.010628614,
0.0044502197,
-0.024358379,
0.013989332,
0.030628987,
-0.02184467,
0.035492465,
-0.01133901,
-0.003061874,
-0.0034375642,
-0.0076504163,
0.006485777,
0.001165493,
0.026311968,
-0.023456722,
-0.0053313836,
0.016147843,
0.005355291,
0.010095817,
0.003449518,
0.005587536,
-0.01434453,
0.0033982876,
-0.0139278555,
0.0121108815,
-0.021448487,
0.015546738,
0.032104425,
0.013354074,
-0.00097167114,
0.015710676,
-0.009330776,
-0.001337969,
-0.0017409819,
-0.046066433,
0.018456629,
0.039126415,
-0.009890895,
-0.000993871,
0.012117713,
0.036175538,
-0.023169832,
0.009856742,
0.03273285,
0.0021038644,
-0.0005861619,
-0.0017068284,
0.025410311,
-0.0034478102,
-0.0029098904,
-0.008169551,
-0.020082342,
0.07174997,
0.004723449,
0.00834032,
0.004013053,
0.010519322,
-0.008838963,
-0.11781641,
-0.019863758,
-0.00712445,
0.0048224945,
-0.025301019,
0.0052186768,
-0.0068102363,
0.0074318326,
-0.013244783,
0.0468588,
0.0068204827,
-0.03065631,
0.003041382,
-0.0016931669,
0.020410217,
-0.0065472536,
0.0066223913,
-0.019098718,
-0.011919621,
0.044700287,
0.0014148147,
0.0076982314,
0.00040237262,
0.0022165715,
-0.00056011975,
-0.022063253,
-0.0071654343,
0.02061514,
-0.0025120005,
0.019932067,
-0.002380509,
-0.027541498,
0.03909909,
-0.008367643,
-0.03150332,
-0.006065687,
-0.015901936,
-0.043552727,
0.026885748,
-0.011701038,
0.0042896974,
0.006543838,
0.002831337,
0.0035212405,
0.020478524,
-0.0043067746,
-0.027022362,
0.013675119,
0.029372133,
-0.0046380647,
-0.00028176757,
-0.015492093,
-0.022281837,
-0.0004422897,
0.008729671,
-0.020779077,
0.024617946,
0.020546831,
0.0007014304,
-0.0029167212,
-0.00027643106,
-0.0053108917,
-0.0007347303,
0.009542528,
0.0034085335,
-0.0012628309,
-0.021243567,
-0.016093196,
0.011024796,
-0.011783007,
-0.010287077,
-0.01575166,
-0.011181903,
-0.0042282213,
-0.021858333,
-0.0017008515,
-0.027541498,
-0.017213436,
0.019235332,
-0.038853183,
-0.013019369,
-0.011967436,
0.02304688,
-0.01743202,
0.020888368,
0.01058763,
0.01650304,
-0.013053522,
-0.011748853,
-0.01658501,
0.005034247,
0.039618228,
-0.012732478,
-0.027008701,
-0.039727516,
0.006123748,
0.011386825,
-0.020164311,
0.03270553,
0.013142322,
-0.0083129965,
-0.012671001,
-0.05445457,
0.014289885,
0.014235239,
-0.015738,
0.027227284,
-0.005727566,
0.015232525,
0.0072815567,
0.006362824,
0.013135491,
-0.012964723,
0.024112472,
-0.019549545,
0.00083249505,
-0.00750014,
-0.024385702,
0.020109665,
-0.0024249086,
0.036749322,
0.015901936,
0.00006729335,
-0.00047132027,
0.03128474,
0.012732478,
-0.01659867,
-0.026708148,
0.0006890498,
0.016079536,
-0.010225601,
-0.0041769906,
0.023647983,
-0.017213436,
-0.022541404,
-0.0029133058,
-0.024836529,
-0.03612089,
0.004583419,
-0.0034939176,
0.01519154,
0.034153644,
-0.025328342,
-0.019822774,
-0.000017356988,
-0.022090577,
-0.020765414,
0.006943436,
-0.032131746,
0.01659867,
-0.015437447,
-0.008675026,
0.0036715167,
-0.01415327,
0.018115092,
-0.031230092,
-0.025492279,
0.009515205,
-0.012411434,
-0.0071654343,
-0.024713576,
-0.02926284,
0.005136708,
0.01331309,
-0.0041462523,
-0.004928371,
0.011769346,
-0.0016888976,
-0.014358192,
0.007985122,
0.024891175,
-0.027404884,
-0.028907644,
-0.0066394685,
0.004293113,
0.013415551,
-0.00093410217,
-0.014850005,
-0.0026400767,
-0.0025205389,
0.0046824645,
0.026243659,
-0.005748058,
0.01256171,
-0.022186207,
0.03204978,
0.013415551,
0.008818471,
-0.017609619,
0.0077870307,
0.011987929,
0.017445682,
-0.016516702,
0.014426499,
0.02203593,
0.009624497,
-0.0008990947,
0.023757275,
-0.0038457003,
0.013019369,
0.007930476,
0.008504258,
-0.014699728,
0.007916815,
0.017049499,
-0.006489192,
-0.0037808083,
0.013511181,
-0.035984278,
-0.017882848,
-0.0012457542,
0.008388135,
0.021981284,
0.024494993,
0.0010485168,
0.004286282,
-0.023005893,
0.015027603,
-0.0036817628,
-0.0040916065,
0.0004901048,
0.02877103,
0.027104331,
0.018729858,
0.0044297273,
0.011557593,
0.0150822485,
-0.008463273,
0.0136204725,
-0.021052307,
0.016940206,
-0.008681856,
0.01959053,
-0.0037364087,
-0.039017122,
0.02053317,
-0.012240666,
-0.027896697,
-0.0073703565,
0.0026093384,
-0.015956583,
0.08579395,
0.021161597,
-0.006072518,
-0.0031199353,
-0.006892205,
0.0097064655,
-0.0001466472,
-0.0024812622,
0.0036817628,
-0.031995133,
0.019959388,
-0.027500514,
0.005174277,
-0.026817441,
-0.02408515,
0.021393843,
-0.004576588,
0.00824469,
0.00478151,
-0.031940486,
0.009993356,
0.010000187,
0.014822681,
0.03404435,
-0.031913165,
-0.0017981894,
0.031148123,
-0.0011885468,
-0.002541031,
-0.016175166,
-0.01500028,
-0.025410311,
-0.020833723,
-0.012602694,
0.015697014,
0.0022148637,
0.0011492701,
-0.0043989895,
-0.0068819593,
0.025478618,
0.013859549,
-0.0045151114,
-0.010512492,
-0.023729952,
0.020546831,
-0.018060446,
-0.0037705621,
-0.023115186,
-0.020478524
] |
BACKGROUND C-reactive protein (CRP) is a known risk factor for cardiovascular events in the healthy population and in patients with coronary artery disease. High CRP levels before cardiac surgery are associated with worse short-term outcome, but its role after discharge home remains unknown. The study objective was to evaluate the effect of CRP on short-term and mid-term outcome after cardiac surgery. METHODS From August 2000 to May 2004, values for preoperative CRP were available for 597 unselected patients undergoing cardiac operations. CRP was used to divide this cohort in two groups: a low inflammatory status (LHS) group of | [
-0.01486709,
0.011800336,
0.025880735,
-0.026240746,
-0.009893615,
0.017600501,
-0.009940282,
0.019947235,
-0.020880593,
-0.01009362,
-0.011873671,
0.003643437,
-0.021160603,
0.0026534088,
0.005706829,
0.003293427,
0.028160801,
-0.013320379,
0.007546881,
0.0005008476,
-0.03013419,
0.013680389,
-0.017280491,
0.004366791,
-0.0023917346,
-0.008160232,
0.015560443,
-0.034774322,
0.017933844,
-0.028640814,
0.009400267,
0.0016500469,
-0.011560328,
0.014533747,
-0.008900253,
-0.0056801615,
-0.0030400865,
0.006803527,
0.0063435137,
-0.009553605,
0.024467362,
-0.009033591,
0.0058501665,
-0.0015992122,
-0.0037967747,
-0.015893785,
0.036214363,
-0.014947092,
-0.028427474,
0.035734348,
0.0339743,
-0.01240702,
-0.022840649,
0.0014325407,
-0.0009016923,
0.0038567763,
0.002786746,
0.03365429,
-0.0023650674,
-0.020853925,
0.013213709,
-0.012780364,
-0.0070335334,
-0.007960226,
0.00070377,
0.005176814,
-0.005816832,
0.034347642,
-0.00457013,
0.005613493,
0.011146984,
0.05760164,
-0.002336733,
-0.0018500526,
0.019733895,
0.016173793,
-0.036241032,
-0.007473546,
0.0012808697,
0.01486709,
0.023760676,
-0.003258426,
0.00199839,
0.017480496,
0.011800336,
-0.02481404,
0.013087039,
0.01077364,
-0.018840536,
-0.024547365,
0.021467278,
0.022080628,
-0.008006894,
-0.0007525214,
-0.01605379,
-0.00036646877,
0.004003447,
0.023534002,
-0.009166927,
-0.03373429,
0.009493603,
-0.0024984044,
-0.0035601011,
-0.017413829,
-0.025080713,
0.012080343,
-0.015440439,
-0.023507334,
0.02654742,
-0.013840393,
-0.0028600814,
0.043867916,
0.0023800677,
-0.013307045,
0.02564073,
-0.018667197,
-0.0067201913,
-0.004490128,
0.0039834464,
-0.017653836,
0.02604074,
0.0069668647,
0.0374944,
-0.011580329,
-0.0028117467,
0.016067123,
-0.025974073,
-0.0018217185,
0.006880196,
-0.0047034672,
-0.013480383,
0.014827088,
0.008160232,
0.014813755,
-0.0096202735,
0.01982723,
-0.023827344,
0.016507136,
-0.016973816,
-0.04349457,
-0.012980369,
0.01942722,
-0.008660247,
-0.013267044,
-0.012713695,
0.0006966865,
0.029387502,
0.013407048,
-0.0019267214,
-0.012573691,
-0.01609379,
-0.0060435054,
0.023227327,
0.002210063,
-0.0069801984,
-0.0021967292,
0.00504681,
0.015533775,
-0.01562711,
-0.0005491823,
-0.009053591,
0.0032367588,
0.0011408657,
0.013840393,
-0.007546881,
-0.0043167896,
0.015613778,
0.003008419,
-0.008126898,
-0.0063968487,
0.0023767343,
0.017493831,
-0.024440695,
0.007980227,
0.017613834,
0.0022283967,
-0.017160488,
-0.00021875622,
-0.016653808,
-0.051814806,
-0.028027464,
-0.011033647,
0.028854154,
0.0024450696,
-0.007920225,
-0.0039367788,
0.043654576,
0.006953531,
0.0037301062,
-0.0146670835,
-0.017600501,
0.01724049,
0.002558406,
-0.023960682,
-0.64257824,
-0.027600786,
-0.0074002105,
0.006463517,
0.036187697,
0.013500384,
0.023387332,
0.0029984186,
-0.022173963,
0.028560812,
0.000090940084,
0.02216063,
-0.007246873,
-0.008946921,
0.005413487,
-0.035227668,
-0.0024917375,
-0.008953588,
-0.011480327,
-0.012960369,
-0.013587053,
0.014747086,
-0.01537377,
0.020320578,
-0.0093535995,
0.010466964,
0.020680588,
-0.018867204,
-0.016067123,
0.036374368,
0.0020467248,
0.026694093,
-0.0121003445,
0.014147069,
0.042694546,
-0.024307357,
-0.022173963,
0.008026895,
0.012720361,
0.042401206,
-0.013400381,
-0.0021267273,
0.010740305,
0.0043334565,
-0.00070251996,
0.019240547,
-0.008666913,
0.020533917,
-0.00018906788,
0.0123670185,
-0.019080542,
0.010720305,
-0.015667113,
-0.006023505,
0.0012483689,
-0.013180375,
0.02169395,
-0.02402735,
-0.021093933,
0.011813669,
-0.0049801418,
0.0036634374,
-0.015160431,
-0.021653948,
0.0018150517,
0.01692048,
-0.007286874,
-0.009453602,
0.0060068374,
-0.0074868794,
0.02072059,
0.017280491,
0.023960682,
-0.026707426,
0.036081027,
0.022680646,
0.008633579,
0.0071202023,
-0.01910721,
-0.0044667935,
0.01724049,
0.017200489,
-0.0064868513,
0.007373543,
-0.0072602066,
0.018787201,
-0.012940368,
0.013827059,
0.005530157,
-0.01020029,
-0.0077602207,
0.009153593,
-0.0035801018,
-0.0052034813,
-0.024827372,
0.027574118,
-0.0024050684,
0.009006923,
0.034294307,
0.005763497,
-0.017800506,
0.0054234876,
-0.00077293866,
0.016827146,
0.013707057,
-0.005786831,
0.0028284139,
0.009120259,
0.03200091,
-0.044694602,
-0.00036688542,
-0.0006521019,
-0.0063501806,
-0.018987207,
0.030000852,
-0.020640587,
0.0067235245,
0.0024050684,
-0.0003125089,
-0.027027436,
0.014027066,
-0.019400552,
0.027494116,
0.008006894,
0.020640587,
0.015067095,
-0.009420268,
-0.014107068,
0.020533917,
-0.0304542,
0.017587166,
-0.00029104995,
0.02118727,
-0.012287016,
0.00996695,
-0.01206701,
0.015853785,
0.03138756,
-0.0052501494,
-0.047494683,
-0.017640501,
-0.018453859,
0.0037167724,
-0.0077068857,
-0.02018724,
-0.014253738,
-0.0056401603,
0.009953616,
0.011460326,
0.03314761,
-0.011560328,
-0.031014215,
0.0023050655,
0.01917388,
-0.030267527,
-0.00022438138,
-0.0027717454,
-0.004740135,
0.007733553,
-0.021520613,
-0.0036067693,
0.018000511,
-0.019200547,
-0.0051801475,
-0.00017292159,
-0.009466936,
0.0080868965,
-0.0029450837,
0.0014858756,
-0.041787855,
-0.00540682,
-0.008166899,
-0.0034367645,
0.001888387,
-0.0035201001,
0.022320636,
-0.03269426,
-0.012480355,
0.0012025342,
-0.005666828,
-0.0025400722,
-0.014600415,
-0.011713667,
-0.0053301514,
0.013773725,
0.016293796,
-0.0119736735,
0.012027008,
-0.0027234107,
0.02952084,
-0.013193709,
0.013167041,
-0.04090783,
0.026574088,
-0.00079335587,
-0.017200489,
-0.023454001,
-0.017413829,
-0.0055568246,
0.0114936605,
0.018320521,
0.0036267699,
0.025120715,
-0.02122727,
0.0023417333,
-0.022587309,
0.02546739,
0.009066924,
0.019147212,
-0.010193624,
-0.009253597,
-0.004406792,
0.0034167639,
-0.02992085,
-0.010733639,
0.017253824,
0.008380238,
-0.019333882,
0.003503433,
0.0043267896,
0.010733639,
-0.0012867033,
0.030400865,
-0.008806917,
-0.015160431,
0.0026884098,
0.027280776,
-0.005283484,
-0.0054901564,
-0.0068935296,
-0.027414113,
-0.0016317131,
0.016973816,
0.020680588,
0.006860195,
0.033574287,
0.0058701667,
-0.0039834464,
0.0023700674,
0.022547308,
-0.00085210754,
0.022200631,
0.01228035,
-0.010533633,
-0.026600756,
-0.016373798,
0.017387161,
0.030320862,
0.009173594,
0.015933786,
0.00056501606,
0.010586968,
-0.0015650445,
0.022013959,
-0.011266987,
0.006693524,
0.005770164,
-0.0039201113,
0.036481038,
0.016360465,
0.03312094,
0.035574347,
0.0016533803,
-0.014320407,
0.016907148,
-0.011393657,
0.006400182,
-0.011300322,
-0.009240263,
-0.0031517562,
-0.017760506,
-0.005776831,
0.01219368,
-0.02973418,
-0.011073648,
0.01917388,
0.03698772,
0.023600671,
0.015867118,
-0.01007362,
-0.0049534743,
-0.02434736,
0.0089069195,
0.014627082,
-0.011980341,
-0.014707085,
0.0019367217,
0.009613607,
-0.003008419,
0.036907718,
0.009226929,
0.0108869765,
0.022147296,
-0.00810023,
0.0038034415,
-0.01348705,
0.038614433,
-0.009800279,
0.017053818,
-0.012867033,
-0.007920225,
-0.0032767598,
0.002798413,
-0.032774266,
0.031200888,
0.010826974,
-0.001323371,
0.005093478,
0.019840565,
0.010640303,
0.0075335475,
-0.019520555,
-0.0066768564,
-0.0031834238,
0.030587537,
0.012040342,
0.0015783783,
-0.013320379,
0.0075935493,
-0.0031867572,
-0.010293626,
-0.0043267896,
-0.008413573,
-0.0111003155,
0.02682743,
0.0093002645,
0.012273682,
0.021027265,
-0.0010733638,
0.0050068093,
-0.0009025257,
-0.027654119,
0.023574004,
0.031547565,
0.02610741,
-0.0027934127,
0.0009408601,
0.016947148,
-0.0067768595,
0.0145070795,
0.01537377,
-0.014787087,
0.013560385,
-0.0048634717,
0.015080429,
0.0042401208,
0.045707967,
0.05373486,
0.011840337,
-0.020480582,
0.012087011,
0.018227184,
0.010926978,
-0.009020257,
-0.026334083,
0.030267527,
-0.01666714,
-0.01964056,
-0.012653694,
0.0019183878,
0.01501376,
0.012260349,
0.0058134985,
0.015400438,
0.012453687,
0.027294109,
0.010693638,
0.013353713,
-0.009940282,
-0.0071135354,
0.01900054,
0.022893984,
-0.00004968891,
-0.037227724,
0.027760789,
0.011867004,
-0.022320636,
-0.0061468417,
0.012727029,
-0.018773867,
0.021173935,
-0.02148061,
0.0062968456,
0.01440041,
-0.010586968,
-0.014360408,
0.012160346,
0.004383458,
-0.011266987,
-0.023173992,
-0.035761017,
-0.02428069,
-0.00092002616,
-0.005060144,
0.0013733724,
-0.013760392,
0.0005233482,
0.02618741,
0.01906721,
0.0016183794,
0.011106983,
0.0051301457,
0.0013158708,
0.015653778,
-0.017213823,
-0.017507164,
0.022760646,
-0.028160801,
0.0087469155,
-0.024907375,
-0.00784689,
-0.018933872,
-0.013987064,
0.01634713,
-0.0074068774,
0.009640275,
0.0050068093,
0.021667283,
-0.004530129,
-0.004896806,
0.0063401805,
-0.012773696,
-0.011406991,
-0.016707141,
0.0039101113,
-0.019987235,
-0.02162728,
-0.00422012,
0.01232035,
0.016120458,
-0.014707085,
-0.012113678,
0.02180062,
0.008833584,
0.04112117,
-0.023574004,
-0.013893728,
0.027467448,
0.0116536645,
0.020600585,
-0.019760562,
0.0144537445,
0.054428216,
0.0010825308,
-0.0034067635,
0.019600557,
0.02521405,
-0.01548044,
-0.003473432,
0.013547052,
-0.015533775,
-0.015000426,
-0.03384096,
-0.007680218,
-0.034507647,
0.025960738,
-0.012433687,
-0.0046134647,
-0.037681073,
-0.0076468843,
-0.0029000824,
0.030400865,
-0.003683438,
-0.012727029,
-0.04482794,
-0.0017433829,
-0.009333598,
-0.005730163,
0.039094444,
-0.027654119,
0.0074802125,
0.014200404,
-0.031547565,
-0.025507392,
0.007366876,
-0.0031250888,
-0.04098783,
-0.015347103,
-0.009540271,
-0.025960738,
-0.005700162,
0.003800108,
0.04298789,
0.020560585,
0.020787258,
-0.0076402174,
-0.009853614,
0.004476794,
0.0060501723,
-0.00014740003,
0.001946722,
-0.00797356,
-0.00948027,
0.020107238,
0.014693751,
0.0020533917,
-0.010340294,
-0.03221425,
-0.005090145,
0.008506909,
-0.020773925,
-0.0014142069,
-0.01580045,
-0.033600956,
-0.017973844,
0.0014208737,
-0.013560385,
0.009146927,
-0.04144118,
-0.0134537155,
0.00043292897,
-0.0049501406,
0.009766945,
-0.018720532,
0.024760704,
-0.017053818,
0.00045459627,
-0.017093819,
0.013500384,
-0.001594212,
-0.0117603345,
-0.016907148,
0.020893928,
0.0026300747,
-0.0022217298,
0.01066697,
-0.0011058648,
-0.0061835092,
-0.030160857,
-0.0050034756,
-0.031627566,
-0.0047768024,
0.00982028,
-0.008886919,
0.019733895,
-0.0057468303,
-0.0041934527,
-0.0070868684,
0.0023200659,
0.0128937,
-0.007920225,
0.015773783,
-0.018933872,
-0.0016108791,
0.020067237,
-0.019027207,
0.0027934127,
-0.032640927,
0.04130784,
0.0054701557,
-0.0109403115,
-0.0028767486,
0.009346932,
0.0019817231,
-0.00786689,
0.005536824,
0.031547565,
-0.023720674,
0.0029384168,
-0.018093849,
0.03178757,
-0.03314761,
-0.034614317,
0.032374255,
-0.015427105,
-0.004420126,
-0.016280463,
-0.016747143,
-0.024400694,
0.02618741,
-0.010393629,
-0.015880452,
0.020440582,
-0.023494001,
-0.0064901845,
0.023960682,
-0.032960936,
0.04037448,
-0.002005057,
-0.016067123,
-0.023480667,
-0.022147296,
0.0024284024,
0.0030200859,
0.023360664,
0.015973788,
0.018893871,
-0.000076877186,
0.0025650728,
-0.006586854,
0.0064868513,
-0.0047634686,
-0.020373913,
0.04026781,
0.014160403,
-0.0027384113,
0.037467733,
-0.007313541,
-0.0035067664,
-0.024694035,
-0.0019717228,
-0.023373999,
-0.034560982,
-0.0017167155,
0.032240916,
0.026814096,
-0.045947973,
-0.009046924,
-0.02262731,
-0.0022533974,
-0.028000796,
-0.00014948341,
0.016293796,
-0.03106755,
-0.007693552,
-0.012480355,
-0.0002170895,
0.016707141,
0.005730163,
-0.011733667,
-0.012400352,
0.006430183,
-0.05186814,
0.023454001,
0.0008600245,
0.011066982,
-0.0090135895,
0.021467278,
-0.027054103,
-0.008300236,
0.012487022,
-0.0075935493,
-0.036054358,
-0.015293769,
0.008726914,
0.022213966,
-0.005933502,
-0.0052434825,
0.02610741,
0.024654035,
-0.022587309,
0.0031334225,
0.01020029,
0.0045201285,
-0.017467164,
-0.008586911,
0.017160488,
-0.025694065,
0.016680473,
-0.023760676,
0.019013874,
0.027467448,
0.00045876304,
-0.018520527,
0.0011266987,
0.0422412,
-0.027360778,
-0.012460355,
-0.037147723,
0.0039767795,
-0.023053989,
0.015000426,
0.017947176,
-0.025947405,
-0.005600159,
0.008126898,
-0.016253795,
0.00084710744,
-0.0062935124,
0.008766916,
0.010760306,
-0.011193652,
-0.0069268635,
-0.001335038,
-0.021600613,
0.028960824,
0.0042701215,
-0.022360636,
-0.029014159,
0.0017583834,
-0.035974357,
-0.011666998,
-0.0051368126,
0.024987377,
0.021133935,
0.0026100741,
0.016013788,
0.038801104,
-0.01698715,
0.027107438,
-0.009780278,
-0.03240092,
-0.007653551,
-0.012160346,
0.028107466,
0.017253824,
-0.025160715,
-0.01020029,
0.025987405,
0.016600473,
0.009160261,
0.02424069,
-0.01242702,
0.011166984,
-0.022480639,
0.018720532,
-0.00375344,
-0.016747143,
-0.017560499,
-0.020733923,
0.01609379,
0.017733838,
-0.02148061,
-0.013367047,
0.0029300833,
0.0013883729,
0.0028934155,
-0.017360494,
-0.017413829,
-0.020680588,
0.003933445,
-0.02158728,
0.01230035,
0.0049968087,
-0.008180233,
0.0054934896,
0.02137394,
-0.0043867915,
-0.020133905,
0.00022813148,
0.019667227,
-0.013267044,
-0.0011125316,
-0.013280378,
-0.03189424,
0.017293826,
0.013207043,
-0.004073449,
0.0016050456,
-0.026067408,
-0.0011300321,
-0.014573748,
-0.00014344158,
0.0014258738,
0.0043301233,
0.00950027,
-0.0051301457,
-0.026174078,
-0.0018700531,
-0.0056934953,
0.0087469155,
0.0077668875,
-0.016587138,
-0.0063635143,
0.0048634717,
-0.000738771,
0.0042767883,
-0.0067868596,
0.0038167753,
0.019413885,
0.1968056,
0.0029750846,
0.0028417474,
0.014427077,
0.008826918,
-0.016400466,
0.00066668564,
0.011413658,
-0.021453943,
0.037867744,
0.03666771,
0.0056568277,
-0.009420268,
0.00023709008,
0.003473432,
-0.018840536,
0.000018880744,
-0.010106954,
0.01045363,
-0.027814124,
0.00270341,
0.0007229372,
0.008280235,
0.005526824,
0.012180346,
-0.0088002505,
0.015000426,
-0.003876777,
0.04733468,
0.019867232,
-0.001139199,
0.0038601097,
-0.01616046,
0.028960824,
-0.0029950852,
0.013800393,
0.010580301,
-0.00411345,
-0.0033084275,
-0.012227015,
-0.010266959,
-0.012147012,
-0.012700361,
-0.023747342,
0.017413829,
0.0027784123,
-0.002243397,
-0.014827088,
-0.017493831,
0.030000852,
-0.029974185,
0.0038034415,
0.00950027,
-0.00002261783,
0.009793612,
0.0031150887,
0.022840649,
0.0017517165,
-0.0050201425,
-0.0063668475,
0.009186928,
-0.0075802156,
-0.024534032,
0.014160403,
-0.05330818,
0.023894012,
-0.0044034584,
-0.018307187,
-0.019440552,
-0.021987291,
0.034614317,
-0.020520583,
-0.0080868965,
0.0040167808,
-0.01032696,
-0.0068468614,
-0.0024750703,
0.016440468,
0.012227015,
0.009473602,
-0.0025450725,
-0.0110469805,
-0.042401206,
0.00034042634,
-0.020213908,
-0.00784689,
0.005596826,
0.009393601,
-0.036107693,
0.00064876844,
0.021507278,
0.008726914,
-0.029787514,
-0.0124203535,
0.02920083,
-0.010633635,
-0.0046367985,
-0.0014500412,
0.0027084104,
0.008106898,
-0.017093819,
0.07552215,
-0.0033917632,
0.018093849,
-0.024294024,
-0.0087469155,
-0.034000967,
0.017307159,
0.0012825364,
-0.0066001876,
0.0077668875,
-0.02076059,
-0.0012975369,
-0.022347301,
0.0022800649,
0.043121226,
0.0088002505,
-0.007420211,
0.017520498,
-0.011847003,
0.0020133907,
0.002973418,
0.010980313,
0.020787258,
0.010206957,
-0.016027123,
-0.011860337,
-0.0065435194,
-0.010600301,
-0.04400125,
-0.0026784095,
-0.02941417,
0.004603464,
-0.005076811,
0.008346904,
0.01219368,
-0.0072802072,
-0.014440411,
0.018840536,
0.01325371,
-0.004530129,
-0.01681381,
0.009066924,
-0.0074402117,
0.010320294,
0.0066201882,
0.0062468443,
0.034240972,
-0.021347273,
0.006750192,
-0.0068335277,
0.0055768252,
-0.001092531,
-0.020307245,
0.014280406,
-0.031147553,
-0.010066953,
-0.02065392,
0.020333912,
-0.013733724,
-0.025600728,
0.010160289,
0.016760476,
-0.006253511,
0.010626969,
-0.015413771,
-0.16821812,
0.014573748,
0.010506965,
-0.01081364,
0.0129137,
0.005223482,
0.003590102,
0.017613834,
0.0036734377,
-0.0018017179,
0.046001308,
0.004366791,
-0.0046301316,
-0.033600956,
-0.004120117,
0.0024800706,
0.003970113,
0.049254734,
0.0039734463,
0.023867344,
0.022573976,
-0.02485404,
0.015813783,
-0.013680389,
0.0013617054,
-0.024000682,
-0.0015042095,
0.030614205,
-0.008433573,
-0.0129737025,
-0.014147069,
-0.0014600415,
0.035441007,
0.011413658,
-0.023280662,
-0.016653808,
-0.007853556,
-0.00799356,
0.004003447,
0.02481404,
0.028427474,
0.02542739,
0.0037167724,
0.018173851,
-0.037414398,
0.033414282,
0.021933958,
-0.015027094,
0.013413715,
-0.0038167753,
-0.005340152,
-0.014187071,
0.012587025,
-0.0031334225,
-0.0012892033,
0.023213994,
-0.0013600386,
-0.014253738,
-0.0054468215,
-0.0027700788,
-0.003218425,
-0.0187472,
0.009153593,
0.011426992,
0.006056839,
-0.01569378,
0.009886947,
0.025507392,
-0.008280235,
0.017427161,
-0.0041067833,
0.013153708,
0.00948027,
-0.019840565,
0.034934327,
0.015307102,
-0.024427362,
0.0164138,
-0.002303399,
0.0077802213,
0.016547138,
0.014600415,
-0.025654063,
-0.030107522,
0.016080458,
0.007800222,
0.00808023,
0.00958694,
-0.0016675474,
-0.023747342,
0.025920738,
-0.046347983,
0.0038534428,
0.001279203,
-0.008660247,
0.017067151,
-0.01228035,
0.0055634915,
-0.027520783,
-0.025400722,
0.021653948,
-0.0145604145,
-0.020627253,
-0.008726914,
0.004866805,
0.0071202023,
-0.012033676,
-0.008873586,
0.027280776,
-0.029254165,
0.0008666913,
0.002245064,
0.012033676,
0.022013959,
-0.010220291,
0.016280463,
-0.009686942,
-0.00750688,
-0.006993532,
-0.046241313,
0.05064144,
-0.0080335615,
-0.007746887,
0.0047701355,
-0.0075802156,
0.009640275,
-0.12245682,
-0.0018367189,
0.018947205,
0.00609684,
0.0033934298,
0.013880394,
-0.013667055,
0.0057568303,
-0.011106983,
0.021813953,
-0.0023817343,
-0.007320208,
-0.010400296,
-0.021400608,
0.037361063,
0.0082269,
0.018600529,
-0.043654576,
0.009473602,
0.023067323,
-0.0022817315,
-0.028747484,
-0.0058534998,
-0.006423516,
0.0043101227,
-0.015347103,
-0.024160687,
0.0009133593,
0.006136841,
0.030054187,
0.0001220868,
0.008186899,
0.022947319,
-0.010853642,
-0.024627367,
-0.020920595,
-0.020600585,
-0.02984085,
0.04098783,
0.003223425,
-0.001442541,
0.0053001507,
0.0077202194,
-0.023467334,
0.0017083819,
0.016613806,
-0.042001195,
0.008340237,
-0.009060258,
-0.027240776,
0.00093919336,
-0.043334566,
-0.017933844,
-0.0017717171,
0.030800875,
-0.01630713,
0.010006951,
0.026320748,
-0.010420296,
-0.015533775,
-0.016040456,
0.0071202023,
-0.036827713,
0.029654177,
0.0052568163,
-0.01828052,
0.002056725,
-0.032454256,
0.01953389,
-0.0050501437,
-0.013033704,
-0.001748383,
-0.031307556,
-0.017520498,
-0.016787143,
0.019080542,
-0.017800506,
-0.010206957,
0.026027407,
-0.039814465,
0.00065418525,
-0.009686942,
0.013533718,
-0.021320606,
-0.011066982,
0.014493746,
0.020227242,
-0.010000285,
0.0062901787,
-0.005456822,
-0.00033313446,
0.034400977,
0.019387217,
0.007746887,
0.023093991,
0.0028950823,
-0.009993617,
-0.027627453,
-0.013473717,
0.0054701557,
-0.0060635055,
-0.0019283881,
-0.048721384,
0.01688048,
0.006430183,
-0.0031234222,
0.0018917205,
-0.023974014,
0.019187212,
-0.003566768,
-0.00057501637,
0.007860224,
-0.059095014,
0.012980369,
-0.009953616,
0.018147184,
-0.023654006,
0.003066754,
0.039201114,
0.019480554,
0.051201455,
0.017933844,
-0.015613778,
0.002978418,
-0.0030767543,
0.01828052,
0.0010891976,
0.0039667794,
0.008106898,
0.023747342,
-0.016907148,
-0.0198939,
0.016640473,
-0.02973418,
-0.020840593,
0.0043334565,
-0.005800165,
-0.026920766,
-0.018507194,
0.021773953,
0.018880537,
0.008980256,
-0.026440753,
-0.018307187,
-0.002890082,
-0.0017008818,
-0.002081726,
-0.001559211,
-0.040854495,
0.010533633,
0.009120259,
-0.017560499,
0.014533747,
0.00088002504,
0.0145604145,
-0.045867972,
-0.0054168208,
0.04381458,
0.0104402965,
-0.0011466993,
-0.0075802156,
-0.013040371,
0.041787855,
-0.007493546,
-0.014253738,
0.0060368385,
0.035601012,
-0.006136841,
-0.016040456,
-0.019507222,
0.020013902,
-0.029334167,
-0.02510738,
0.012813698,
-0.020333912,
-0.008573577,
0.022320636,
-0.0032567594,
-0.007880224,
0.014853756,
-0.00060251716,
0.004666799,
-0.0075935493,
0.003683438,
-0.011700333,
0.027307443,
0.021667283,
0.021160603,
-0.007920225,
0.013140374,
-0.017013818,
0.01580045,
0.0023167327,
0.015920453,
-0.002495071,
0.0032767598,
0.012680361,
0.024307357,
-0.011933672,
0.014147069,
0.006383515,
0.0269741,
0.0071202023,
0.018533861,
-0.02564073,
-0.034987662,
-0.005013476,
-0.012800364,
-0.0009908616,
-0.019547222,
0.004296789,
0.005210148,
0.019507222,
-0.0015300435,
0.00609684,
0.017373828,
-0.0030300862,
-0.004923473,
-0.015147097,
-0.0030217527,
-0.0036534371,
0.008613578,
-0.0041234507,
0.008940254,
-0.02320066,
0.008300236,
0.0125270225,
0.008093564,
0.01688048,
-0.018293854,
0.01932055,
0.019733895,
0.022240633,
-0.014267072,
-0.023467334,
-0.004983475,
0.016613806,
-0.017907176,
-0.0051401462,
0.01724049,
0.003405097,
0.07648218,
0.002361734,
-0.016800478,
0.0020800591,
-0.013633721,
0.01666714,
0.0042801215,
0.00960694,
-0.00043334565,
-0.009360266,
0.0014100401,
-0.010466964,
0.008233568,
-0.06288179,
-0.021240603,
-0.0032750932,
0.016867146,
0.032240916,
0.008933587,
-0.03261426,
-0.009280263,
-0.014960425,
0.0152271,
0.0029217498,
-0.028880822,
-0.0056968285,
0.024680702,
-0.03261426,
0.008153565,
-0.021213936,
-0.0011333656,
0.021093933,
-0.022493973,
-0.00994695,
0.012233681,
0.00048209704,
0.0021133935,
-0.01372039,
0.0041434513,
-0.014480412,
-0.018307187,
0.010140289,
-0.026427418,
-0.026120743,
-0.027387446,
-0.0316009,
-0.009560272,
0.0049468074,
-0.011947006
] |
Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, we found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA. We tested whether the delivery and efficacy of gemcitabine in the mice could be improved by coadministration of IPI-926, a drug that depletes tumor-associated stromal tissue by inhibition of the Hedgehog cellular | [
-0.0042364285,
0.00065802014,
0.018777316,
-0.023159595,
-0.009754979,
0.02081243,
-0.027840357,
0.016850742,
-0.02808457,
0.0021555247,
0.016905012,
0.023837967,
0.030065414,
0.009266552,
-0.0050233393,
0.0031459467,
0.039454073,
-0.00092088897,
-0.019808441,
-0.0031544263,
-0.03630643,
0.004999596,
0.0002476055,
0.0039956067,
0.011715472,
0.012007171,
0.02123302,
-0.036170755,
-0.015982427,
-0.009205498,
0.0039718635,
0.0088527445,
-0.0059153973,
0.007950511,
0.00533539,
0.0020198503,
0.004792693,
-0.0037920952,
0.006698916,
-0.01717636,
0.0002927596,
-0.0012922973,
0.009185147,
-0.008140455,
-0.024244988,
0.0059764506,
-0.008310048,
-0.028681537,
-0.01986271,
0.0028474634,
0.009700709,
-0.0032697495,
0.0011727343,
-0.008601747,
0.0029916172,
0.00034024558,
0.01227852,
0.018709479,
-0.008710287,
-0.0012863615,
0.0007479043,
0.0045416956,
-0.032181934,
0.02518114,
-0.0049928124,
0.0015789091,
-0.00011140128,
0.012013955,
0.0190758,
0.012007171,
0.032643225,
0.03066238,
-0.0032222634,
-0.014177959,
0.0077741346,
-0.0038565407,
-0.02792176,
0.005759372,
0.00068769883,
0.006261367,
0.02402791,
-0.037744578,
-0.00646827,
0.020988807,
0.015819618,
-0.01443574,
-0.021490801,
-0.010121299,
-0.0029814416,
-0.0031951286,
0.011905416,
0.03128648,
-0.00311542,
0.018410996,
0.0025625473,
0.008676369,
0.014408605,
0.027094148,
0.022331981,
-0.0369848,
-0.0081811575,
0.021192318,
-0.024109315,
-0.019727036,
0.0022064026,
0.015114112,
-0.0007411206,
0.023593752,
0.020500379,
0.013906611,
-0.006841374,
0.047567394,
0.0013185841,
-0.02976693,
0.023946505,
-0.009001986,
0.030228224,
0.0028423755,
-0.0050131637,
-0.010528322,
0.010982831,
0.008920582,
0.013519939,
-0.022386251,
0.023620887,
0.0013092565,
-0.02355305,
0.0022725437,
0.008995203,
0.007997997,
0.009375091,
0.008791692,
0.031015133,
-0.009205498,
-0.024855522,
0.00017998037,
-0.03614362,
-0.009029121,
-0.03234474,
-0.04650913,
-0.008520343,
0.027324794,
-0.000920041,
0.0116951205,
-0.020717459,
0.018098945,
0.017298467,
-0.0032901005,
-0.004724856,
0.01485633,
0.0041346727,
-0.017719056,
-0.009816032,
-0.0226576,
-0.002643952,
-0.0008237971,
-0.001626395,
0.020120492,
-0.01653869,
-0.01293654,
0.0013974448,
0.0013949008,
0.0014423869,
0.011172774,
0.028057436,
0.025425354,
-0.009863518,
0.019292878,
-0.0033969441,
-0.012061441,
0.017054254,
0.0280303,
-0.013329995,
0.0060748146,
-0.019211475,
0.009490414,
-0.008432155,
0.017827597,
-0.027039878,
-0.015399028,
-0.004246604,
0.012671975,
-0.0061494354,
-0.0022064026,
-0.013865909,
-0.008215076,
0.0028152408,
-0.0018994395,
-0.006183354,
-0.04078368,
0.017515546,
0.008635666,
0.0017722449,
-0.009856734,
-0.6369092,
-0.028654402,
0.0002429417,
-0.014774926,
0.0022928948,
0.03513963,
0.008784908,
-0.014164392,
-0.014123689,
-0.008981636,
-0.0016391146,
0.022345548,
0.023091758,
-0.02197923,
-0.020418976,
-0.019401418,
-0.002572723,
-0.01406942,
0.004534912,
0.0021826595,
-0.004460291,
0.012855135,
-0.019727036,
-0.0081811575,
0.009381874,
-0.00017870843,
0.024774117,
0.004433156,
0.0050572576,
0.034027103,
-0.008248994,
0.01754268,
-0.008377885,
-0.009225849,
0.053021498,
-0.0052200668,
0.0042805225,
0.008839178,
0.013092565,
0.040865086,
-0.0055117663,
0.013241807,
-0.0034834363,
0.005783115,
-0.041434918,
0.01246168,
0.030445302,
0.00091919303,
-0.002406522,
-0.004551871,
0.008866312,
-0.004456899,
-0.031069404,
0.0031578182,
0.015304056,
-0.0125023825,
0.030038279,
-0.032290474,
0.00851356,
-0.00966679,
0.036333565,
0.021585774,
0.00049181917,
-0.031015133,
-0.0035716246,
0.022589764,
0.00049605896,
0.0076452442,
-0.010928561,
0.012176764,
0.014842764,
0.022725437,
-0.0042398204,
0.01008738,
0.03652351,
0.02492336,
0.010202704,
0.02813884,
-0.0044670748,
-0.0025812027,
0.01622664,
-0.0018061635,
-0.03288744,
0.021138048,
0.03619789,
0.021612909,
-0.015493999,
0.006885468,
0.015765348,
0.00059823866,
0.0184924,
0.016674366,
-0.029142829,
-0.025208276,
-0.00816759,
-0.0015178557,
0.0022776315,
0.022101335,
-0.002313246,
-0.03267036,
-0.03820587,
-0.005857736,
-0.0015899326,
-0.017881867,
0.045070987,
0.008147239,
-0.027582575,
-0.0030085766,
0.012943324,
-0.028193109,
-0.004456899,
0.0012015651,
0.004416197,
-0.005708494,
0.021897824,
-0.018139647,
0.0044704666,
-0.004185551,
0.0029627865,
-0.029142829,
0.012766947,
-0.016470853,
-0.00002785032,
-0.008235427,
0.0035003957,
-0.008276129,
-0.0037480013,
-0.014367904,
0.010596159,
0.009096959,
0.0029169964,
-0.0026626072,
-0.0017018638,
-0.02197923,
0.006023937,
-0.0012320918,
0.0023437727,
-0.000591031,
-0.011288098,
-0.029549852,
-0.010331594,
0.0026778704,
-0.0022250577,
0.022223443,
-0.001156623,
-0.006637863,
-0.014354336,
-0.0094090095,
0.00782162,
-0.01043335,
0.0016484421,
-0.023091758,
0.013601344,
0.037283283,
0.040186714,
-0.009829599,
0.012705893,
-0.010630078,
0.010623294,
-0.0032867088,
0.005928965,
0.0067599695,
-0.010738617,
-0.0016068919,
-0.031177944,
-0.017759759,
0.02282041,
0.016715068,
-0.012671975,
-0.03182918,
-0.008689936,
-0.0052268505,
0.0072789234,
0.022169173,
0.0046773697,
-0.008710287,
-0.01264484,
-0.03619789,
-0.020703891,
0.0113288,
0.0061426517,
-0.010786103,
0.005783115,
0.010243406,
0.04384992,
0.012244601,
0.028518727,
0.020106925,
-0.0033291068,
0.021382261,
-0.025167573,
0.018736614,
-0.021585774,
0.01723063,
0.006671781,
-0.014503578,
0.0067904964,
0.021138048,
-0.00066692376,
0.041109297,
0.017814029,
-0.019306445,
0.009883869,
-0.0024930143,
0.024217853,
-0.023363106,
-0.0050572576,
-0.014679954,
0.026388641,
-0.017854732,
-0.0028712063,
0.0072789234,
-0.01586032,
-0.008255778,
-0.007794486,
0.017624086,
-0.009999192,
-0.02128729,
0.0025167575,
-0.018031107,
-0.026836367,
0.011505176,
0.0047587743,
-0.018397428,
0.01299081,
-0.0063359877,
0.026782097,
0.016769337,
0.0017637652,
-0.028193109,
-0.006814239,
0.021273723,
-0.0076384605,
0.014557847,
-0.0009844863,
0.0030323195,
-0.0021775716,
-0.009843167,
0.041516323,
0.007997997,
0.0075163534,
0.004606141,
-0.006532715,
0.0009225849,
0.011396637,
0.015683943,
0.018641641,
0.009497197,
-0.029576987,
0.015249786,
-0.009395442,
0.019957682,
-0.0069533056,
0.0208667,
-0.003944729,
-0.030038279,
0.014462875,
0.023580184,
0.03625216,
0.005067433,
0.029848335,
-0.009700709,
0.013628478,
-0.019957682,
0.0042025098,
0.018790884,
0.003235831,
0.0025405004,
0.015901022,
0.013370697,
-0.00013535627,
-0.0058679115,
0.01354029,
-0.048028685,
0.0069329543,
0.011837578,
0.006132476,
-0.010704698,
0.023064623,
-0.0036733802,
0.0052980795,
-0.047078963,
0.025642434,
0.0015008964,
-0.006464878,
-0.0030713258,
-0.017922569,
0.003044191,
0.0048978403,
0.010555456,
0.005209891,
0.015995994,
0.0069940076,
0.028247379,
-0.008689936,
-0.041543454,
0.018899424,
-0.0056338734,
-0.0048571383,
-0.005047082,
0.0044026296,
-0.008845961,
-0.0020503772,
-0.0152633535,
0.0268228,
0.015019139,
-0.007841972,
-0.023946505,
0.0072043026,
-0.0086560175,
-0.027758952,
-0.02017476,
-0.012373492,
-0.023308836,
-0.0060137613,
0.006132476,
0.010901426,
0.012963675,
0.037853114,
0.009314037,
-0.008330399,
-0.021219453,
0.01449001,
-0.011878281,
0.033864293,
-0.0022979826,
-0.005315039,
-0.005284512,
0.025154006,
-0.0012922973,
0.0016603137,
-0.009069824,
0.029251369,
-0.02081243,
0.0039989986,
0.008927366,
-0.00084626814,
0.00449421,
0.019428553,
0.025533894,
-0.0345698,
-0.03603508,
-0.021138048,
-0.006298677,
0.0031255956,
-0.0061256923,
0.03641497,
0.0043144412,
0.02355305,
-0.0032697495,
0.005264161,
0.012875486,
0.021545071,
0.017325602,
-0.00015273952,
0.005165797,
-0.010168785,
0.016497988,
-0.006207097,
-0.031856313,
0.037500363,
0.00911731,
0.0008212532,
0.00898842,
0.020608919,
0.013058647,
0.0029017332,
-0.011688337,
0.007997997,
-0.0056644,
-0.005443929,
-0.011301666,
0.0063359877,
-0.02976693,
0.039345533,
-0.013391049,
-0.002618513,
-0.0028237205,
0.028464457,
0.018098945,
0.010304459,
-0.013472453,
-0.0109421285,
-0.008791692,
0.0031730814,
-0.012821217,
-0.019740604,
-0.007808053,
-0.008065835,
-0.004728248,
-0.022508359,
-0.01918434,
-0.009219065,
-0.023403808,
0.0057661557,
-0.010480836,
-0.016837174,
0.014462875,
0.010168785,
0.00004035779,
0.007665595,
-0.011701904,
-0.009151229,
0.02676853,
-0.007251789,
-0.0012159805,
0.0013270638,
-0.02128729,
0.018845154,
0.012353141,
-0.011009965,
-0.013336779,
-0.011003181,
0.010263757,
0.013207888,
-0.0060069775,
-0.015073409,
-0.010948912,
0.0038395813,
-0.001015013,
0.013092565,
0.013391049,
-0.010284108,
0.0035071794,
0.00026477678,
-0.013838774,
-0.036116485,
-0.017352737,
0.0011608629,
-0.01569751,
-0.009558251,
-0.0024150016,
-0.006498797,
-0.011790092,
-0.00721787,
-0.002009675,
-0.003537706,
-0.035980813,
0.023932938,
0.024584174,
-0.029549852,
0.0062444075,
-0.01288227,
0.0013813335,
-0.009449712,
0.009164795,
0.033321597,
0.010324811,
-0.006159611,
0.004799477,
-0.024652012,
-0.038341545,
-0.027053446,
-0.010833589,
0.008377885,
0.033864293,
0.008147239,
-0.0012193724,
-0.025886647,
-0.026565019,
-0.0116951205,
0.0052302424,
-0.012577003,
-0.036007944,
-0.011281314,
0.006729443,
0.012068225,
-0.023471646,
0.02313246,
-0.028464457,
-0.032290474,
0.01648442,
0.0074756513,
0.002857639,
-0.011030316,
0.00066819566,
0.009849951,
0.00065462827,
-0.02713485,
-0.020825997,
-0.01443574,
0.005647441,
0.013852341,
0.06572061,
0.038178734,
-0.02371586,
0.021165183,
0.037337553,
0.010372297,
0.012047874,
0.008913798,
0.020798862,
-0.0077537834,
0.037473228,
0.020473244,
-0.0049419347,
0.036849126,
-0.015453298,
0.030309627,
-0.010311243,
-0.00449421,
-0.03595368,
-0.012454896,
-0.014191527,
-0.041082162,
0.000093859024,
-0.02566957,
-0.021219453,
-0.03077092,
-0.013838774,
0.021680746,
-0.0035444899,
0.002454008,
-0.03193772,
0.020731026,
-0.010820022,
0.008059051,
0.013126484,
0.011267747,
0.007482435,
-0.028952885,
0.003751393,
0.0034393424,
-0.005644049,
0.0064547025,
0.013316427,
0.012922972,
-0.037825983,
0.0055558607,
-0.00013514428,
-0.026470046,
-0.005423578,
-0.007550272,
-0.0184924,
-0.026836367,
-0.014666387,
-0.02676853,
-0.024434933,
-0.013323211,
0.009205498,
-0.023390241,
0.015209083,
-0.015344758,
-0.012841568,
-0.014191527,
-0.015019139,
-0.0064513106,
-0.012380276,
0.027623277,
0.03261609,
-0.008737422,
-0.009368307,
-0.003961688,
0.01807181,
0.0052946876,
0.011179558,
0.021802852,
0.008364318,
-0.023037488,
0.010982831,
0.024475634,
-0.022196308,
-0.017515546,
0.03410851,
0.0051115276,
0.001202413,
-0.024326393,
-0.030228224,
-0.030065414,
-0.0067938883,
-0.014544279,
0.027202688,
-0.0010497795,
-0.016986417,
-0.011084586,
0.015154813,
-0.0014347552,
0.013662397,
-0.0022352333,
-0.013798071,
-0.020364705,
-0.022331981,
-0.01211571,
0.004701113,
-0.0014033805,
0.010372297,
0.015534702,
0.004551871,
0.002454008,
-0.0025082778,
0.014666387,
0.0015653417,
-0.0024031303,
0.04040379,
0.002945827,
-0.015480432,
0.02887148,
-0.0068617254,
-0.00051471416,
-0.016009562,
-0.01396088,
-0.010134866,
-0.033375867,
-0.010663996,
0.0025591555,
0.0063359877,
-0.005142054,
-0.0073264097,
-0.021775717,
-0.014598549,
-0.021422964,
-0.017868299,
0.006946522,
-0.033213057,
-0.020798862,
-0.019632064,
-0.009015554,
0.0137302345,
0.015100544,
-0.003351154,
-0.0037615686,
0.03372862,
-0.014245796,
0.02307819,
0.000897146,
0.011606933,
-0.02022903,
-0.0022250577,
-0.008791692,
-0.01743414,
0.017800462,
-0.033430137,
-0.020256165,
-0.03367435,
-0.009944922,
0.0025608514,
0.013092565,
0.004599357,
0.015168381,
0.01765122,
0.011817227,
0.0025795067,
-0.019808441,
0.011701904,
-0.040593736,
0.012427761,
0.02371586,
-0.005789899,
-0.01233279,
-0.023335971,
0.0014618901,
-0.0013898131,
-0.0019706686,
-0.005040298,
-0.03261609,
-0.0005638961,
0.0030051847,
-0.0016891444,
-0.0072110863,
0.0025557638,
-0.021694312,
0.027284091,
0.01622664,
-0.012156413,
-0.010155218,
0.00013567426,
-0.036849126,
0.009558251,
-0.026388641,
0.001321976,
-0.018397428,
-0.019577794,
-0.05215318,
-0.00083354866,
-0.03481401,
0.028790075,
0.018003972,
-0.0052607693,
-0.03462407,
0.008330399,
-0.03671345,
-0.0061935293,
-0.0066514304,
0.036387835,
0.000058350528,
0.014652819,
-0.013879476,
0.02229128,
0.0016560738,
0.014327201,
-0.0064140004,
-0.012617705,
0.016416585,
-0.023946505,
0.012149629,
0.013004377,
-0.02518114,
-0.045450874,
0.0096328715,
0.012671975,
-0.0008844265,
0.008377885,
-0.0052573774,
0.022413386,
0.0019435337,
-0.0022335374,
-0.0045145606,
0.007916593,
0.02201993,
-0.017203495,
-0.0056983186,
0.017637653,
-0.00425678,
0.002759275,
-0.015616106,
0.01019592,
0.0074688676,
-0.011817227,
0.012075008,
-0.00054184906,
-0.00995849,
0.005376092,
-0.0190758,
-0.011335583,
0.0051250947,
0.017895434,
0.0045213443,
-0.008581396,
-0.022928948,
-0.0074756513,
-0.021992797,
0.008696719,
-0.000613502,
0.004182159,
0.0012990809,
-0.016837174,
0.023837967,
-0.024000775,
-0.016362315,
-0.012013955,
-0.011776525,
-0.02676853,
0.044853907,
-0.013499588,
0.010881075,
-0.026985608,
0.01691858,
-0.022196308,
-0.018790884,
-0.015887454,
0.004246604,
-0.036632046,
-0.0045213443,
-0.011416988,
-0.010494404,
-0.0052336343,
-0.002759275,
-0.025208276,
-0.031422157,
0.0036835559,
0.2005808,
0.0066853487,
0.009612521,
0.019143637,
0.0063495548,
-0.012814433,
0.020961672,
0.012081792,
-0.0022962866,
0.0051997155,
0.020934537,
-0.011505176,
-0.022535494,
-0.0017909001,
0.020473244,
0.002450616,
-0.038233005,
-0.026402209,
-0.020256165,
-0.030065414,
-0.009741412,
0.00096498313,
0.027365496,
0.014395038,
0.026049456,
-0.0007470563,
-0.011742607,
0.0025778108,
0.025099736,
0.0066514304,
-0.022535494,
0.0049690693,
0.006848158,
-0.00068345905,
0.000212627,
-0.009368307,
-0.033158787,
-0.017678356,
0.005175973,
-0.0037174744,
-0.024122883,
0.0063088527,
-0.031666372,
0.00623084,
-0.026510749,
0.017936137,
-0.0022250577,
-0.011966469,
0.01818035,
0.0071703843,
-0.028572997,
0.0132011045,
0.04558655,
0.0089341495,
-0.029414177,
-0.0024370488,
0.01543973,
0.0184924,
0.002521845,
0.020825997,
-0.005237026,
0.007665595,
-0.01259057,
0.030798055,
-0.014205094,
0.019360716,
-0.023295268,
0.010121299,
0.026727827,
-0.0042025098,
0.011498393,
-0.010019544,
-0.010697914,
-0.002214882,
-0.0043415762,
-0.015629673,
0.012251385,
0.016999984,
0.0051590134,
0.019523526,
0.014951303,
-0.0024268732,
-0.019889845,
0.0031272916,
-0.030906595,
-0.028003165,
0.021355128,
0.005732237,
-0.0036530292,
-0.00571867,
-0.0052031074,
0.01299081,
-0.017407006,
0.002757579,
0.016213072,
0.014476443,
0.011966469,
0.02486909,
0.010948912,
-0.0030764136,
-0.022644032,
0.06365836,
-0.0057220617,
0.018926557,
-0.006403825,
0.0057288455,
-0.015453298,
0.010121299,
0.0018858721,
0.010114515,
0.00017181873,
-0.014897033,
-0.013743802,
-0.022223443,
-0.0027982814,
0.030743785,
0.016891444,
-0.028545862,
-0.0019231825,
-0.000966679,
0.00006460426,
-0.025574597,
0.0044535073,
0.026035888,
-0.006257975,
0.0011176167,
-0.020106925,
-0.017895434,
0.014422173,
-0.007719865,
-0.011098154,
-0.013180753,
-0.011491609,
0.0053286063,
0.004884273,
0.016362315,
0.01538546,
0.012129278,
-0.00845929,
0.031096539,
0.006196921,
0.001721367,
0.013988015,
0.01617237,
0.016009562,
-0.019808441,
0.047024697,
-0.025316816,
-0.022250578,
-0.026849935,
-0.019102935,
-0.01902153,
-0.0104129985,
-0.00009041417,
0.022956083,
-0.018831586,
-0.0043042656,
-0.019984817,
0.008669585,
0.010406215,
-0.028762942,
0.021110913,
0.032073393,
0.010867507,
-0.008927366,
-0.009775329,
-0.17257765,
0.023213865,
0.024774117,
-0.009178363,
0.026483614,
0.023335971,
0.01354029,
-0.0010099252,
0.0043721027,
0.0045450875,
0.018912992,
0.004155024,
-0.01648442,
0.015995994,
0.0116679855,
0.005684751,
-0.020052655,
0.030282494,
0.030472437,
0.0015424467,
0.017108522,
-0.008310048,
0.021531504,
-0.03066238,
-0.017759759,
0.00027028855,
-0.0031052444,
-0.016240207,
-0.0142593635,
-0.016348748,
-0.012692326,
0.008669585,
0.03220907,
-0.005247202,
0.01138307,
-0.006702308,
-0.0078012696,
-0.00297805,
-0.00613926,
0.017990407,
0.028111706,
0.02592735,
0.0073060584,
-0.0017637652,
-0.009001986,
0.0104129985,
-0.004958894,
0.004195726,
0.026619287,
-0.009266552,
0.04157059,
-0.004083795,
0.014924168,
0.021165183,
0.021436531,
0.035410978,
0.021151615,
0.009524332,
-0.0013940529,
-0.003846365,
-0.0117222555,
-0.004199118,
0.021300858,
0.023742994,
0.0062477994,
-0.051501945,
-0.0018078594,
-0.006536107,
-0.025018333,
0.015181948,
-0.039752554,
-0.010779319,
0.008615315,
-0.022209875,
0.014571414,
0.0056745755,
-0.008438938,
-0.000020139147,
0.010718266,
0.016430153,
-0.016185937,
0.0012431153,
-0.03383716,
-0.012346357,
-0.019876277,
0.017054254,
0.018370293,
0.0070414934,
0.011342367,
-0.015765348,
0.021680746,
-0.02450277,
0.021382261,
-0.029088559,
0.024326393,
0.031232212,
-0.001487329,
-0.014110122,
0.012000388,
-0.011247396,
0.0036292863,
-0.011539095,
-0.019822009,
0.015100544,
0.04895127,
0.010887858,
-0.037744578,
-0.012312438,
0.039101318,
-0.0037683523,
-0.01938785,
0.01902153,
0.0091580115,
-0.0011447514,
-0.01918434,
0.029658392,
0.0070686284,
-0.0142593635,
-0.0048300033,
-0.025059035,
0.056766108,
0.0061697867,
0.018316023,
0.038178734,
0.024706282,
-0.013336779,
-0.12601425,
-0.04458256,
0.019170772,
-0.00042906983,
-0.021355128,
0.0040736194,
0.0015119199,
0.01854667,
-0.03888424,
0.04195048,
0.004863922,
-0.029224234,
-0.008092969,
-0.0016543779,
0.03239901,
-0.0047180722,
0.01193255,
-0.0059764506,
-0.019238608,
0.0345698,
-0.010630078,
0.008737422,
0.009741412,
-0.026578587,
-0.014829196,
-0.008968068,
-0.02687707,
0.024991198,
0.017352737,
0.007360328,
0.029956875,
0.004249996,
0.024163583,
0.0053930515,
-0.03988823,
0.003591976,
-0.009931355,
-0.025845945,
0.05421543,
-0.026836367,
0.0004506929,
0.009883869,
0.010792887,
0.021531504,
0.010541889,
-0.024421366,
-0.019781306,
-0.0023726034,
0.020636054,
-0.018872289,
-0.031367887,
-0.019482823,
0.010786103,
0.024000775,
0.012292087,
-0.028952885,
0.030038279,
0.009334388,
-0.0024709674,
-0.01591459,
-0.004358535,
-0.019618496,
-0.012617705,
0.015738213,
0.01633518,
-0.007197519,
-0.018533103,
-0.019306445,
0.023335971,
-0.010630078,
-0.0122242505,
-0.023498781,
-0.029332774,
-0.0109692635,
-0.039345533,
-0.0000013878787,
-0.0021216061,
0.0013737018,
0.00877134,
-0.0017739409,
-0.0021606125,
-0.015806051,
0.022426954,
-0.00919193,
0.027813222,
-0.0009997496,
0.00500638,
-0.014096554,
0.0021368694,
-0.017990407,
0.0007601998,
0.032860305,
-0.01659296,
-0.018370293,
-0.01485633,
0.013140052,
0.017936137,
-0.004226253,
0.016810039,
0.035980813,
-0.0016823608,
-0.0026456479,
-0.05812285,
0.026985608,
-0.00038264378,
-0.004938543,
0.008445722,
-0.025656002,
-0.004602749,
-0.0028627268,
0.015005572,
-0.0220742,
-0.03082519,
0.016308045,
-0.009219065,
-0.0024760552,
-0.0037208663,
-0.01664723,
0.01818035,
0.0033782888,
-0.019320013,
0.029332774,
-0.00046086847,
0.0020232422,
0.0027338362,
-0.0039074183,
-0.0064513106,
-0.009090175,
-0.016959282,
0.032697495,
-0.0075638397,
-0.008574612,
0.0007627437,
-0.030119684,
-0.0077062976,
-0.01854667,
-0.016728636,
-0.002262368,
-0.0032646616,
0.015819618,
0.024489202,
0.040919352,
-0.00044306123,
-0.051040653,
0.0015441426,
-0.014381471,
-0.0074960026,
0.00071186584,
-0.020405408,
0.025642434,
-0.007150033,
0.008208293,
0.015846752,
0.0148156285,
0.005650833,
-0.024244988,
-0.0084050195,
-0.026280103,
0.0014194918,
-0.015371893,
-0.03665918,
-0.0096871415,
0.026470046,
0.0014508666,
-0.0030391032,
0.0008852745,
0.010128083,
0.0069736564,
-0.03226334,
-0.010046679,
0.008269345,
0.0019163988,
-0.019876277,
-0.010725049,
0.0059153973,
0.008025132,
0.015901022,
-0.018668776,
-0.0232817,
0.019930547,
0.012366708,
0.026280103,
-0.005783115,
-0.0030560626,
-0.027094148,
0.017854732,
0.022440521,
-0.005623698,
-0.0018773924,
0.015073409,
0.012285303,
0.0068786847,
-0.0017807245,
0.011688337,
-0.0055592526,
0.029169964,
-0.012305655,
0.012509166,
-0.022413386,
-0.021314425,
0.0034054236,
0.03283317,
-0.00032434627,
-0.0011786701,
-0.004738423,
0.0017654612,
-0.021260155,
0.0036326782,
-0.019089367,
-0.035492383,
0.0044026296,
0.010480836,
0.01659296,
-0.006305461,
-0.004792693,
0.010399431,
-0.002009675,
0.0084050195,
0.008466073,
-0.0019859318,
0.005138662,
0.03595368,
0.0076452442,
0.0147342235,
0.010894642,
0.010318027,
0.006709092,
0.011593365,
0.035655193,
-0.030798055,
0.0536456,
-0.011457691,
0.020310435,
-0.015792483,
-0.033620078,
-0.012997594,
0.009626088,
-0.0043076575,
-0.0029051248,
0.008018348,
-0.009944922,
0.078202635,
0.012081792,
-0.00948363,
-0.01019592,
-0.022956083,
0.015209083,
0.01596886,
0.019835576,
0.010039895,
-0.029549852,
0.0063088527,
-0.016362315,
0.02898002,
-0.030743785,
-0.025045468,
0.020242598,
-0.023010353,
-0.0010582592,
0.0016552259,
-0.01335713,
0.005047082,
0.00060587033,
-0.0064580943,
0.01569751,
-0.03641497,
-0.011573014,
0.02391937,
0.014340769,
-0.0018740006,
-0.04178767,
0.010419782,
-0.003917594,
-0.033755753,
-0.022576196,
0.008608531,
-0.0064140004,
-0.005237026,
-0.030580977,
0.02134156,
0.02170788,
0.0034834363,
0.034542665,
-0.03999677,
-0.026727827,
0.00036695646,
-0.008466073,
-0.015670376,
-0.020364705,
-0.0037174744
] |
Cu/Zn-superoxide dismutase is misfolded in familial and sporadic amyotrophic lateral sclerosis, but it is not clear how this triggers endoplasmic reticulum (ER) stress or other pathogenic processes. Here, we demonstrate that mutant SOD1 (mSOD1) is predominantly found in the cytoplasm in neuronal cells. Furthermore, we show that mSOD1 inhibits secretory protein transport from the ER to Golgi apparatus. ER-Golgi transport is linked to ER stress, Golgi fragmentation and axonal transport and we also show that inhibition of ER-Golgi | [
-0.003464458,
0.0007560013,
0.012247221,
-0.022982439,
-0.034184407,
0.033079986,
-0.014291711,
0.011011323,
-0.028188987,
0.0005427596,
0.012773135,
0.012667952,
0.004164581,
0.033079986,
-0.018288657,
-0.019734921,
0.020497495,
0.019143268,
0.0059592626,
0.024520738,
-0.018472727,
0.011024471,
-0.00046633775,
-0.011136228,
0.016395368,
0.00644902,
0.02621681,
-0.028767493,
-0.008197684,
-0.009893756,
-0.0042533292,
-0.012529899,
-0.0056075575,
0.0034611712,
0.014659851,
-0.00889452,
0.021010263,
-0.005380757,
0.011208541,
-0.03807617,
0.0149754,
0.014896513,
-0.018130884,
0.023311136,
0.0032097185,
0.012404995,
-0.012201204,
-0.012687674,
-0.009170624,
0.01304924,
0.031370766,
0.022956144,
-0.020813044,
-0.029924504,
-0.029740434,
-0.029477477,
-0.006274811,
0.014633556,
0.011714733,
-0.015343539,
0.019038085,
0.0059296796,
-0.038549494,
0.021115445,
-0.0109981755,
0.0068960465,
0.018604206,
-0.0138972765,
0.010846975,
0.00027384504,
0.041415725,
0.025901262,
-0.010294765,
0.0029533354,
0.027268639,
-0.017144796,
-0.032159638,
-0.010327635,
0.010432818,
-0.0026164218,
0.028425649,
-0.02236449,
0.00025597218,
0.012937483,
0.026598098,
0.0012235717,
-0.009249511,
0.017000169,
-0.027294934,
0.0026805177,
0.008546102,
0.03213334,
0.017434048,
0.00822398,
-0.014265416,
0.006955212,
-0.013634319,
0.017157942,
-0.004134998,
-0.02427093,
-0.007106412,
0.00082995795,
-0.01636907,
-0.011754177,
-0.03258037,
-0.013778945,
0.01748664,
-0.005492514,
-0.006777716,
-0.011234837,
-0.012076299,
0.021864872,
-0.007461404,
-0.0005296118,
0.015724827,
-0.008230553,
0.041100174,
0.011234837,
-0.024152597,
-0.005975697,
-0.009387564,
0.022495968,
0.026177367,
-0.02981932,
0.013226735,
-0.00022762213,
-0.028451944,
0.008184535,
0.0044801296,
-0.007862413,
0.021062853,
0.016737211,
0.011556959,
-0.014449486,
-0.016027227,
0.01778904,
-0.018051997,
0.00022988192,
-0.01636907,
-0.040916104,
0.01809144,
0.0054103397,
-0.01827551,
-0.012490456,
-0.015422426,
0.03258037,
0.02169395,
0.016513698,
0.0048219734,
0.015396131,
0.010873271,
-0.006284672,
0.0068894727,
-0.02236449,
0.008427771,
0.029240815,
-0.016421663,
0.013220162,
-0.019301042,
-0.03599881,
0.009190346,
-0.006830307,
-0.008611841,
-0.022390787,
-0.0048219734,
0.03244889,
0.001424898,
-0.0073102037,
0.013989311,
0.0021825428,
-0.022772074,
0.022588003,
-0.018959198,
0.025322756,
-0.02090508,
0.010860123,
0.014462634,
-0.0009039146,
-0.028320465,
-0.02676902,
-0.012543048,
0.022469673,
0.031581134,
-0.0023205953,
-0.0050060432,
-0.0011890585,
0.034920685,
0.0064851763,
0.020195095,
-0.028425649,
-0.015146322,
0.010294765,
-0.0026460045,
-0.027610483,
-0.63151747,
-0.039706502,
0.00049550954,
-0.00045770948,
-0.017263126,
0.039469842,
-0.00874332,
-0.008276571,
-0.017013317,
0.02981932,
-0.0068040118,
0.02236449,
-0.0045787385,
-0.022140978,
-0.0033691362,
-0.027663074,
-0.014436338,
-0.0007264186,
0.041152768,
-0.008546102,
-0.03636695,
0.012470734,
-0.014396895,
-0.0016590941,
0.019524556,
0.03226482,
0.0008702232,
-0.044702686,
-0.00990033,
0.02097082,
-0.01435745,
0.027216047,
0.0062912456,
0.021680802,
0.05127661,
0.013364788,
-0.0144757815,
0.016658325,
0.017999405,
0.04638561,
-0.009492747,
0.0062090717,
0.009959496,
-0.025138687,
-0.019511407,
0.023902789,
0.003822737,
-0.00064876414,
0.015777418,
-0.0035860757,
0.010005513,
-0.000007639619,
-0.027794553,
-0.013022944,
0.01304924,
0.013765798,
0.02097082,
-0.027110863,
0.015987784,
0.010761514,
0.0028152831,
0.025046652,
-0.014396895,
-0.012654805,
0.0042105988,
-0.0080727795,
-0.023127066,
-0.020418609,
0.021352107,
0.009453303,
0.019524556,
0.01650055,
-0.015685383,
0.03594622,
0.001605681,
0.028241578,
-0.0038950501,
0.01974807,
-0.009998939,
0.015922045,
-0.011497794,
0.021523029,
-0.012142038,
-0.01606667,
0.029135633,
0.007895283,
-0.013778945,
0.031449653,
-0.015488165,
0.006176202,
0.0033461275,
0.0013829893,
-0.017328864,
-0.036261767,
-0.014449486,
0.01246416,
0.0026180653,
0.025454234,
0.029793026,
-0.008283145,
-0.021523029,
-0.013437102,
0.006882899,
-0.0046543386,
0.018078292,
0.032475185,
-0.037313595,
-0.0026246393,
0.037182115,
-0.00931525,
0.019182712,
0.003160414,
0.0015752766,
-0.011103358,
-0.018591058,
-0.026808463,
0.009052293,
0.023311136,
0.0002356341,
-0.03231741,
-0.009131181,
-0.0029089616,
0.0048351213,
0.0019179424,
-0.001267124,
0.0004630508,
0.005029052,
-0.014646703,
0.00867758,
-0.0055286703,
-0.013042666,
-0.0076717697,
0.02903045,
-0.0299508,
0.016040375,
0.007665196,
0.00968339,
0.00418759,
0.006531194,
-0.025993297,
-0.034315884,
-0.004861417,
-0.014672999,
-0.00048729216,
-0.030792262,
-0.008039909,
-0.009545338,
-0.0064621675,
-0.0016138984,
-0.003556493,
-0.009104885,
0.002774196,
-0.016408516,
0.01552761,
0.000105490944,
-0.014580964,
-0.030029686,
-0.0020181949,
-0.007625752,
-0.007500848,
0.014344303,
0.03520994,
-0.010577444,
0.015067435,
-0.020234538,
-0.011833064,
0.0046641994,
0.019787513,
-0.0220095,
-0.016973872,
0.0023633258,
-0.008802485,
-0.02120748,
0.018998642,
0.012181481,
0.006981508,
0.0016927855,
0.013088684,
-0.00027733744,
-0.000550977,
0.0041317116,
-0.027084569,
-0.00968339,
-0.0022006212,
0.03457884,
0.020326573,
0.0201688,
0.015304096,
-0.0025802653,
0.03826024,
0.0032360142,
0.01472559,
-0.000560427,
-0.003638667,
0.0033198318,
-0.019301042,
0.003553206,
0.009709686,
0.006656098,
0.014410042,
0.015856305,
-0.035841037,
0.0022384212,
-0.008145092,
0.019945286,
-0.00953219,
-0.001542407,
-0.023929084,
0.023403171,
0.0036813975,
0.011806768,
0.01130715,
0.0007218991,
-0.008151666,
-0.013857832,
0.01686869,
0.011892229,
-0.01636907,
0.00018119378,
-0.025743488,
-0.022653744,
-0.0027626918,
0.0030355095,
-0.011616125,
0.0066265156,
0.024297224,
0.00014729699,
0.016539993,
0.010183008,
-0.018183475,
-0.0073956647,
0.0032360142,
0.0070472467,
0.017447196,
-0.0019705337,
0.023705572,
0.018301805,
-0.009308677,
0.05035626,
-0.008966832,
-0.012404995,
-0.001171802,
0.011668716,
0.018840868,
0.00021611777,
-0.014765034,
0.025782932,
0.009558486,
-0.008552675,
0.011806768,
-0.029530069,
0.016710917,
-0.020918228,
-0.0050060432,
0.0032130056,
0.0045590163,
0.0010386801,
0.007106412,
0.035972513,
0.024665365,
0.017328864,
-0.0019294468,
0.019143268,
-0.0027955612,
-0.0018587771,
0.0098674605,
-0.0013139631,
-0.013437102,
0.007711213,
0.004134998,
-0.03189668,
0.014594112,
-0.006343837,
-0.016237592,
0.0123326825,
0.024441851,
-0.0062813847,
0.016053524,
0.03129188,
-0.008841928,
-0.010229026,
-0.0305556,
0.019301042,
0.000013456001,
-0.028031213,
-0.010189583,
-0.014107642,
0.0010378583,
0.0034381624,
0.026085332,
-0.010005513,
0.0056864447,
-0.015987784,
0.02193061,
-0.00730363,
-0.006764568,
0.011714733,
-0.016697768,
0.023205953,
0.0035433453,
-0.0075994567,
0.0030634487,
-0.024454998,
0.007027525,
0.038891338,
0.020103062,
-0.0041547203,
0.012536474,
-0.006343837,
-0.03733989,
-0.009282381,
-0.008624989,
-0.003334623,
0.00867758,
-0.008611841,
-0.025033504,
-0.0010321061,
-0.017302569,
0.030450417,
0.013003223,
-0.023311136,
-0.040863514,
-0.012247221,
-0.00797417,
0.002849796,
0.042993464,
-0.020129357,
0.015816862,
0.014896513,
0.018564763,
-0.00041826593,
-0.031870384,
0.0086512845,
-0.0049731736,
-0.01686869,
-0.03476291,
0.0119842645,
-0.0021808995,
0.02903045,
0.022719482,
0.00678429,
-0.0201688,
0.017591821,
-0.009525617,
0.010380226,
-0.006508185,
0.008335736,
0.02413945,
0.03189668,
-0.014410042,
-0.004608321,
0.01219463,
0.015488165,
-0.0220095,
-0.0045031384,
0.024862582,
0.005811349,
0.004345364,
0.0009901974,
-0.026072184,
0.004184303,
0.024297224,
0.005216409,
0.017263126,
0.014396895,
0.0058639403,
0.017276274,
0.00834231,
-0.0026180653,
-0.023915937,
0.0040166676,
0.003477606,
-0.0028399352,
-0.020510644,
0.031870384,
-0.018472727,
0.008901093,
-0.018617354,
0.017499786,
-0.016474254,
-0.001134002,
-0.0072444645,
-0.027242342,
-0.014935956,
-0.011951394,
0.005052061,
-0.002606561,
0.014751886,
-0.0047233645,
-0.004269764,
0.010544575,
-0.011254558,
-0.0031209707,
-0.009308677,
0.010150139,
-0.026361438,
-0.041257948,
0.001323824,
0.012030281,
0.015225208,
-0.0025572565,
-0.020379165,
0.013154423,
0.0067974376,
-0.020024173,
-0.01219463,
-0.00075189257,
-0.02939859,
0.0050093303,
0.009788574,
0.019708626,
-0.014830774,
-0.011517515,
0.01078781,
0.016053524,
-0.020734157,
-0.00444726,
0.0023419606,
0.0045491555,
-0.00871045,
0.03844431,
0.04107388,
-0.008697302,
0.012759987,
0.010413096,
-0.017710153,
-0.027636778,
-0.027321229,
-0.01870939,
-0.028188987,
-0.008276571,
-0.0064161504,
0.008960259,
-0.010932436,
0.013377936,
0.0036846846,
0.017144796,
-0.008256849,
0.0023994823,
0.016881838,
-0.010242174,
0.035499193,
-0.0071458556,
-0.0054366356,
-0.0011759107,
-0.02243023,
0.030897444,
0.004519573,
0.0040528243,
0.014133938,
0.012595639,
-0.034131814,
-0.004710217,
-0.00035684084,
-0.0009951278,
0.040022053,
-0.0063011064,
-0.019787513,
-0.02645347,
-0.012365552,
-0.0134042315,
0.00304044,
0.019419372,
-0.013029518,
-0.020418609,
-0.003973937,
-0.033106282,
-0.013976163,
0.014173381,
-0.033632196,
-0.014449486,
0.0132596055,
0.015001696,
0.001193989,
0.0130558135,
0.0023666127,
-0.03244889,
-0.009078589,
-0.013331919,
-0.026545506,
0.017026464,
0.0072444645,
0.019498259,
0.03765544,
0.04283569,
-0.003392145,
0.007481126,
0.03702434,
0.000937606,
0.013174145,
-0.019524556,
0.012444438,
-0.014567817,
0.0186305,
0.014791329,
-0.0073693693,
0.029240815,
-0.032922212,
0.0033658494,
0.017026464,
-0.009663668,
-0.020089913,
0.014199677,
-0.040048346,
-0.021168036,
0.021457288,
-0.019393077,
-0.0050257654,
-0.034815505,
-0.021286367,
0.026676985,
0.009768852,
-0.0077046393,
-0.032922212,
0.014133938,
-0.029556364,
0.03641954,
0.027005682,
0.01405505,
-0.0204712,
-0.0299508,
0.002619709,
0.009650521,
0.008309441,
-0.0045392946,
0.0070472467,
0.01747349,
-0.001903151,
0.03073967,
0.02492832,
-0.025533123,
-0.013101831,
-0.009321825,
-0.03350072,
-0.026663838,
-0.026308846,
0.0071655777,
-0.049593687,
0.011964542,
0.005462931,
-0.004355225,
-0.0006056228,
-0.0073956647,
-0.013331919,
0.020497495,
-0.0075797345,
0.032054454,
-0.0013460111,
0.0092889555,
0.02633514,
-0.015501314,
-0.017828483,
-0.01145835,
0.029424885,
-0.006025002,
0.018038848,
0.015619644,
-0.030713374,
-0.0099332,
-0.0009540408,
-0.012490456,
0.001105241,
-0.013174145,
0.020103062,
0.016881838,
0.018748833,
-0.0055812616,
-0.017946813,
-0.00045935297,
0.013193866,
-0.00834231,
0.0024257782,
-0.016894985,
0.012516752,
-0.018617354,
0.009703113,
0.0028711616,
0.01509373,
0.010353931,
-0.013502841,
-0.01460726,
-0.015685383,
0.015396131,
0.0010814106,
-0.009854313,
0.044518616,
-0.0112019675,
0.004605034,
0.0017519508,
0.031738907,
0.00050701393,
-0.021562472,
-0.0069946554,
0.029977094,
-0.019419372,
-0.0070998385,
0.019077528,
-0.0010838758,
-0.0067974376,
-0.009032572,
-0.00065821415,
-0.020615827,
-0.034421068,
-0.019393077,
0.022338195,
0.015514461,
0.004460408,
0.003043727,
-0.0055220965,
-0.00052468135,
-0.025888113,
-0.029687842,
0.0024438563,
-0.032343708,
-0.007737509,
-0.0018078292,
0.02457333,
0.02511239,
-0.0036090845,
-0.0027561178,
-0.008256849,
0.023797607,
-0.017841632,
0.011504368,
0.018696241,
0.0035301973,
-0.013805241,
0.009742556,
-0.016198149,
-0.026085332,
0.010327635,
-0.012404995,
-0.025993297,
-0.0201688,
-0.020195095,
0.0046444777,
0.021496732,
-0.020234538,
0.019537704,
-0.003569641,
0.0077440827,
-0.00889452,
-0.0305556,
0.022403935,
-0.015816862,
0.0048252605,
0.0008915885,
-0.012806005,
-0.011543811,
0.024823138,
-0.013272753,
-0.012326108,
0.011806768,
-0.004148146,
-0.005190113,
-0.014133938,
-0.0014240764,
0.0008529667,
0.020865636,
-0.009788574,
-0.016789803,
-0.0107089225,
0.0071984474,
0.003088101,
-0.02718975,
-0.011773898,
0.0119250985,
0.008118796,
-0.00025186347,
0.0015366548,
0.0069880816,
-0.014922808,
-0.022140978,
-0.016645176,
-0.015514461,
0.022680039,
0.014028754,
-0.016973872,
0.006199211,
0.021983203,
-0.04443973,
-0.0041317116,
-0.027584186,
-0.002476726,
0.017039612,
0.02097082,
-0.01638222,
0.0042073117,
0.004286199,
0.038365424,
-0.00571274,
-0.0040495372,
0.010399948,
0.0023501778,
0.006593646,
0.010301339,
-0.039653912,
-0.025480531,
0.01686869,
0.011504368,
-0.0069354903,
0.02346891,
-0.0034940408,
0.0026262829,
-0.012286665,
0.009722834,
0.014396895,
-0.00222363,
0.02879379,
-0.003832598,
-0.010183008,
0.0063799936,
0.0019935425,
0.008565824,
0.004831834,
0.016539993,
0.00053166616,
-0.024376111,
0.011405759,
-0.016829247,
0.0033592754,
0.0038391717,
-0.0010584018,
0.032001864,
0.013660614,
-0.006071019,
0.032238524,
-0.015553905,
-0.025953854,
-0.016737211,
-0.011169097,
-0.0006368489,
0.0031193271,
-0.01078781,
-0.005886949,
-0.009722834,
0.0032031445,
-0.022298751,
-0.01204343,
-0.015369835,
-0.0036090845,
-0.04223089,
0.026164219,
-0.022259308,
-0.0013895632,
-0.012654805,
0.015843159,
-0.012746839,
-0.0077966745,
0.0015728114,
0.0009811582,
-0.021549324,
-0.024704808,
-0.017881075,
-0.012115743,
-0.0052755745,
-0.01710535,
-0.015304096,
-0.008776189,
0.03226482,
0.19385189,
0.0009663669,
0.0036025106,
0.008979981,
-0.015304096,
-0.004792391,
0.00022762213,
-0.005469505,
0.0021891168,
0.0036551019,
0.0044932775,
0.009538764,
-0.0057850536,
-0.002203908,
-0.0015276157,
-0.009775425,
-0.026019592,
-0.000696836,
-0.025138687,
-0.003477606,
0.028162692,
-0.00556154,
0.0016960725,
-0.005824497,
0.031370766,
-0.0058770883,
-0.025493678,
-0.0086512845,
0.033053692,
0.030029686,
-0.004509712,
-0.011267707,
0.0040659723,
0.00044990296,
0.015698532,
0.0007120382,
-0.010748366,
-0.013805241,
0.0018045423,
0.003122614,
-0.009519042,
-0.0030618052,
-0.016171854,
0.017933665,
-0.026926795,
0.005663436,
-0.014436338,
-0.01249703,
-0.004529434,
0.008329162,
-0.050382555,
0.008079353,
0.0048285476,
0.029004155,
0.014160233,
-0.012214351,
0.007862413,
0.016487403,
0.008210831,
0.006343837,
-0.021891167,
0.0032475186,
-0.0336059,
0.029845616,
-0.018367544,
0.031633724,
-0.022193568,
-0.0034020059,
0.027479004,
-0.004098842,
-0.007316778,
-0.013621171,
-0.0059329667,
-0.018801423,
-0.009118033,
0.014331155,
0.025967002,
0.016553141,
0.015041139,
0.025493678,
-0.013101831,
0.00901285,
-0.04265162,
0.019826956,
0.0036715367,
-0.044544913,
-0.0011989195,
0.0150279915,
-0.003129188,
-0.023902789,
0.0053084437,
-0.015475018,
0.007737509,
-0.005045487,
-0.0039410675,
-0.008335736,
0.01797311,
0.001602394,
0.005114513,
-0.030292643,
-0.02561201,
0.091456436,
-0.009551912,
0.004062685,
-0.0051769656,
-0.0029023876,
0.00045729862,
-0.00032725817,
-0.0061400454,
-0.008250275,
-0.0063767065,
-0.019577147,
-0.004460408,
-0.020037321,
-0.009295529,
0.008026762,
0.020221392,
-0.014830774,
0.043913815,
-0.016329627,
0.019379929,
-0.017447196,
-0.009256085,
-0.0016566289,
0.0016188289,
-0.002480013,
-0.022680039,
0.010682627,
-0.034605138,
-0.043072354,
0.0144757815,
0.0030453703,
0.001120854,
-0.0014668069,
0.0028152831,
-0.009374416,
0.0097819995,
0.007724361,
0.006863177,
-0.0036682498,
-0.010117269,
-0.0036288062,
0.008164814,
-0.0029779878,
-0.0152778,
-0.0070866905,
0.031134106,
0.007980744,
-0.011938247,
-0.028977858,
-0.012424717,
-0.020326573,
-0.0038654676,
-0.012398422,
0.016645176,
-0.057482395,
-0.023797607,
-0.02529646,
-0.015501314,
0.008256849,
-0.015724827,
0.02658495,
0.014265416,
-0.014410042,
-0.0094335815,
0.0047529475,
-0.16513698,
0.015593349,
0.0027479003,
-0.018301805,
0.012115743,
0.017407753,
0.014396895,
0.012970353,
-0.0046280427,
0.012595639,
0.020615827,
0.012391848,
-0.06216303,
0.012188056,
-0.0061794887,
0.016539993,
-0.01460726,
0.018814571,
0.009295529,
-0.00822398,
0.021536177,
-0.0415472,
0.011169097,
-0.022272456,
0.006610081,
0.01906438,
0.028004918,
0.0024964479,
-0.015777418,
-0.012444438,
-0.0027643351,
0.006163054,
0.04194164,
-0.017775891,
0.027636778,
0.0024635782,
-0.00696836,
-0.020076765,
0.006409576,
0.008322588,
0.008572398,
0.029924504,
-0.0144757815,
0.013338492,
-0.026111627,
0.035841037,
-0.007560013,
-0.0005464575,
0.010426244,
0.0004063507,
0.030634487,
-0.004703643,
0.015133174,
0.035131052,
0.014278564,
0.0049863216,
-0.0036945455,
0.011103358,
-0.0065476284,
-0.009440156,
-0.021496732,
-0.023153361,
0.033632196,
0.01164242,
0.0074285343,
-0.02634829,
0.009663668,
-0.008559249,
-0.043361604,
0.006869751,
-0.021260072,
-0.002305804,
0.0029270397,
-0.020865636,
0.016842395,
0.020681566,
-0.012595639,
-0.004443973,
-0.018354397,
-0.019511407,
-0.0097819995,
0.010150139,
-0.016921282,
-0.012069725,
-0.02303503,
0.0005649466,
-0.0028645876,
0.017526083,
0.0056700096,
0.004233607,
0.005091504,
-0.02304818,
0.011090211,
-0.020273983,
0.0072444645,
0.0035433453,
-0.0092889555,
-0.0011742673,
-0.014633556,
0.005568114,
0.0065772114,
-0.001732229,
-0.037602846,
-0.0045491555,
0.041704975,
0.017079055,
-0.0057028793,
0.01393672,
0.04699041,
-0.023390023,
0.010044957,
-0.004023242,
0.0080990745,
0.0452286,
-0.0078032482,
0.0056831576,
0.015580201,
0.0009877321,
-0.0019278033,
-0.011668716,
0.069210276,
-0.0018275509,
-0.003569641,
-0.018998642,
-0.003097962,
-0.044413432,
-0.12664008,
-0.025283312,
-0.020747306,
0.038155057,
-0.0059526884,
0.010544575,
0.007875562,
0.056325383,
-0.0045261467,
0.04070574,
-0.005614131,
-0.019340485,
-0.003385571,
-0.010807532,
0.011708159,
0.0019195859,
0.013213588,
-0.001371485,
-0.03087115,
0.027715664,
-0.0031324748,
-0.016921282,
-0.006616655,
0.0034020059,
-0.014291711,
-0.008730171,
-0.023994824,
0.020628974,
0.005926393,
0.017841632,
0.014515225,
-0.011931673,
0.015290948,
0.012569344,
-0.01286517,
-0.00871045,
0.0136080235,
-0.05054033,
0.035131052,
-0.008414623,
-0.011648994,
0.003265597,
0.02102341,
-0.008500084,
-0.0041514332,
-0.0028941701,
-0.004864704,
0.012589065,
0.021667656,
-0.007882135,
-0.026690133,
-0.011445202,
-0.024060562,
-0.006928916,
0.033474423,
0.011655568,
0.02035287,
0.041021287,
-0.029740434,
-0.013673763,
0.03271185,
-0.0057751928,
-0.0023140213,
-0.0061301845,
0.027110863,
-0.0055714007,
-0.019958435,
-0.048752222,
0.009420434,
-0.02554627,
0.010925862,
-0.005029052,
-0.0043157814,
-0.004355225,
-0.033211466,
0.014949104,
0.00026706568,
0.006149906,
0.0048877127,
-0.015448722,
0.0023830475,
-0.018893458,
0.015659088,
-0.036892865,
0.022982439,
0.01906438,
0.0151726175,
0.0010230669,
0.003347771,
-0.028820084,
-0.0016508767,
0.03933836,
0.0036912586,
-0.0009630799,
-0.01675036,
0.02243023,
-0.011372889,
-0.01405505,
0.019485112,
0.013778945,
-0.034447365,
-0.041021287,
-0.047332257,
0.0046477644,
0.018157179,
0.0024126302,
-0.0072839083,
0.005390618,
-0.0021069427,
-0.0126811005,
0.0058705145,
0.024415554,
0.0003911485,
-0.017854778,
0.03581474,
0.0018784989,
-0.02457333,
-0.018130884,
0.036340654,
-0.015961489,
0.033711083,
0.030450417,
-0.004434112,
0.013831537,
-0.011464924,
0.025493678,
-0.015238357,
0.003464458,
-0.009689964,
0.018051997,
-0.01179362,
-0.019143268,
0.0019343772,
-0.041389428,
-0.015304096,
0.016763506,
-0.004236894,
-0.020142505,
0.010853549,
0.015290948,
0.029424885,
0.031397063,
-0.014804478,
-0.037760623,
-0.011096784,
0.01636907,
-0.022522265,
0.010439392,
-0.03978539,
0.008414623,
0.00715243,
0.0010616888,
0.023574093,
-0.0059921322,
0.01583001,
-0.030687079,
0.0055451053,
0.002166108,
0.0070932643,
-0.004171155,
-0.012306387,
-0.0020247686,
0.006593646,
0.011872508,
0.020221392,
0.011629272,
-0.0019623165,
0.019905843,
-0.030450417,
-0.0036320933,
-0.008348884,
-0.0056305663,
-0.015882602,
0.011149376,
0.016553141,
0.021076001,
-0.0014421546,
-0.00053289876,
-0.018117735,
-0.023324283,
-0.0123326825,
0.015908897,
0.0040462506,
0.0024553607,
-0.010367079,
0.019393077,
0.016605733,
0.013765798,
0.013101831,
0.018104587,
0.008243701,
0.0008694015,
0.001957386,
0.027268639,
-0.021378402,
0.020366017,
0.027294934,
0.016290184,
-0.010163287,
-0.012490456,
0.012023708,
0.02499406,
-0.021470437,
0.0030552314,
-0.0027725527,
-0.015685383,
-0.012227499,
0.016947577,
-0.03276444,
-0.037918396,
-0.018144032,
0.0048482693,
-0.010978454,
0.004417677,
-0.008256849,
0.007178725,
-0.0009655451,
0.013700059,
0.01955085,
-0.016855542,
0.01356858,
0.011432054,
0.014462634,
-0.0063931416,
-0.008184535,
0.013338492,
0.014383746,
0.016079819,
0.025007209,
-0.033395536,
0.023021882,
-0.028451944,
0.029293407,
-0.010426244,
-0.032001864,
-0.023705572,
0.009670243,
-0.0034283015,
0.00797417,
0.024218338,
-0.005213122,
0.100975476,
0.009847739,
0.001988612,
-0.0077309352,
-0.0048482693,
0.021483585,
0.0020247686,
0.015737975,
0.004943591,
-0.044939347,
0.015120026,
-0.01906438,
0.008874798,
-0.013844685,
-0.0305556,
0.01686869,
0.0032951797,
-0.0026969525,
-0.0051178,
-0.010814105,
0.017775891,
-0.01668462,
0.00522627,
0.013949867,
-0.020615827,
0.008828781,
0.053091012,
0.0026410741,
0.020195095,
-0.035972513,
-0.015120026,
-0.0014643417,
-0.020550087,
-0.013437102,
0.0046773474,
-0.016290184,
-0.011905377,
-0.0070735426,
0.005305157,
0.015001696,
-0.016579438,
0.023429466,
-0.0026082045,
-0.014068198,
-0.0013156066,
-0.014659851,
-0.005663436,
-0.00067547074,
-0.028741198
] |
Understanding local variability in malaria transmission risk is critically important when designing intervention or vaccine trials. Using a combination of field data, satellite image analysis, and GIS modeling, we developed a high-resolution map of malaria entomological inoculation rates (EIR) in The Gambia, West Africa. The analyses are based on the variation in exposure to malaria parasites experienced in 48 villages in 1996 and 21 villages in 1997. The entomological inoculation rate (EIR) varied from 0 to 166 infective bites per person per rainy season. Detailed field surveys identified the major Anopheles gambiae s | [
-0.013372868,
0.015740633,
0.003438261,
-0.019475698,
-0.0033865706,
0.018488575,
-0.017674863,
-0.019502377,
-0.022423733,
-0.040952325,
-0.006162858,
0.0028329804,
0.01220566,
0.0008116264,
0.008557302,
0.017301356,
0.02389108,
0.014753508,
0.01417991,
0.00832386,
-0.021476626,
0.02581197,
-0.0018725351,
-0.006052807,
0.0047955574,
0.013512934,
0.010298109,
-0.029960562,
-0.016541004,
0.007823628,
0.009184259,
-0.012058926,
-0.023464214,
-0.014219928,
-0.04546108,
-0.014806867,
0.021743417,
-0.006849843,
0.010898387,
0.012972683,
0.0052024126,
0.007256699,
-0.0038818002,
0.00721668,
0.0020109327,
0.020929705,
0.00008024555,
0.008697366,
-0.013492924,
0.029693771,
-0.0070099174,
-0.0006857347,
-0.018075049,
-0.00915091,
-0.022036886,
-0.0024778158,
-0.008717376,
-0.009137571,
0.020943046,
-0.026625682,
-0.019782508,
-0.0012697555,
-0.03633685,
-0.009210939,
-0.013179446,
0.018795382,
0.011238545,
-0.0046521574,
-0.0014014833,
0.02247709,
0.049036074,
0.03724394,
0.006172863,
-0.0037283958,
0.025385106,
-0.009224278,
-0.0045087575,
0.013659668,
0.011998897,
0.006683099,
0.018715346,
0.008143777,
-0.033775665,
0.009811217,
0.026599001,
0.0009954616,
0.015247071,
0.026252175,
-0.009010846,
0.01137194,
-0.0103314575,
0.016034102,
0.007356745,
0.006556374,
0.012525809,
-0.007923675,
-0.017914975,
0.034255885,
0.025905346,
-0.017568147,
-0.011825484,
-0.00749681,
-0.0026629015,
-0.015340447,
-0.013699686,
0.0015090331,
0.009684491,
-0.0054825423,
0.018782044,
-0.039218187,
-0.013939798,
0.020702934,
0.011978889,
-0.0016215853,
0.006776476,
0.0046988456,
0.0053191334,
0.000046115136,
-0.0032431707,
-0.0046788366,
0.0042853206,
-0.010118025,
-0.0026412248,
0.0027279318,
0.0210631,
0.019315625,
-0.012792599,
-0.019809186,
-0.00035704058,
-0.02418455,
-0.02331748,
0.015607238,
0.019915903,
-0.010851699,
-0.020382786,
0.012986022,
-0.03502958,
-0.009264296,
-0.022303676,
-0.010464853,
0.0055725845,
0.01249246,
0.0016949527,
-0.032361675,
0.006186202,
0.024077833,
0.009190929,
0.01996926,
0.014219928,
-0.0009962954,
0.019529056,
-0.011171848,
0.010298109,
0.000418319,
0.0005394168,
0.007990372,
-0.014620113,
0.02219696,
-0.03332212,
-0.012645865,
0.0021276535,
-0.013566291,
-0.021503305,
0.010151374,
0.006386295,
0.023904419,
-0.012058926,
0.0002786709,
0.021783436,
-0.0057593375,
-0.0140064955,
0.04023199,
-0.020249391,
0.013713026,
0.007883656,
0.024384642,
-0.009044195,
0.013179446,
-0.009210939,
-0.017874956,
-0.0238644,
0.022690523,
0.024931561,
-0.011978889,
-0.017047906,
-0.00777694,
0.013793063,
0.014646793,
0.0035849959,
-0.011738777,
0.0041786046,
-0.00250116,
0.0020976395,
-0.016434288,
-0.6637745,
-0.0043520182,
0.0018058375,
0.013266152,
0.0059260814,
-0.009230947,
0.018275142,
-0.008177126,
-0.0052591055,
0.032361675,
-0.014219928,
0.028333139,
0.0029630407,
-0.029933881,
-0.02136991,
-0.03249507,
-0.0205562,
-0.0011530347,
0.0068698525,
-0.0067864805,
-0.026025403,
0.0076435446,
0.0038351119,
0.014566755,
-0.01084503,
0.012979353,
0.0040452094,
-0.024878204,
-0.012005568,
0.0040652184,
-0.001735805,
0.04724858,
-0.0018742025,
0.033695627,
0.040098596,
-0.044367243,
-0.00006664549,
0.018555272,
0.025211692,
0.057039786,
-0.017714882,
-0.0114186285,
0.031507947,
-0.0014773518,
-0.01248579,
0.034229208,
-0.0034349263,
-0.015020299,
-0.00095711055,
-0.0322016,
-0.007856977,
-0.002971378,
-0.040712215,
0.016460966,
0.025678575,
-0.002444467,
-0.017034566,
-0.009197598,
0.024904883,
0.0047488688,
-0.014139891,
-0.019115532,
-0.0097912075,
-0.006556374,
-0.017114604,
0.009771198,
-0.007136643,
0.009277636,
0.003995186,
-0.024731468,
0.02136991,
0.023024011,
-0.025104975,
0.009591115,
0.00889079,
0.023517573,
-0.001658269,
-0.0002676241,
-0.018128406,
-0.010238081,
-0.006019458,
-0.0063962997,
-0.03081429,
0.017581487,
0.0073233964,
-0.020422805,
-0.00063070917,
0.004218623,
-0.007890326,
0.013252812,
0.02107644,
0.025465142,
0.010251421,
-0.005722654,
-0.00042478033,
0.009931272,
-0.009877915,
0.009250957,
0.022957314,
-0.020329427,
-0.035082936,
-0.012092275,
0.0062028766,
-0.026025403,
0.024824847,
0.011552024,
-0.017741561,
-0.0040085255,
0.026425589,
-0.0065130205,
-0.007970363,
-0.0010855034,
-0.00026720724,
-0.0024578064,
0.027826238,
-0.027185941,
0.012012238,
0.013106078,
0.002792962,
-0.028413177,
0.020142674,
-0.0051757335,
0.04135251,
-0.030440783,
-0.010464853,
0.009057534,
-0.009784537,
0.004635483,
0.0019925907,
-0.011758787,
-0.00078703166,
0.0088707805,
0.019729149,
-0.017834937,
0.030013919,
-0.0053558173,
0.02633221,
-0.005389166,
-0.006876522,
-0.032441713,
-0.01695453,
-0.02273054,
0.0064263134,
-0.0055625797,
-0.004942292,
-0.021743417,
0.0070966245,
-0.011031782,
0.0023410856,
-0.00048314073,
0.008277172,
0.0059594302,
0.000038246904,
0.01580733,
-0.0025078296,
-0.004131916,
-0.003775084,
-0.020662915,
-0.02079631,
-0.0034582703,
0.01856861,
-0.00071533176,
-0.0011113487,
0.002251044,
0.0014973611,
-0.01748811,
0.0037950934,
0.013026041,
0.007410103,
-0.020662915,
0.025718594,
-0.017688204,
-0.011471987,
0.033829022,
0.017167961,
0.029346943,
-0.010391486,
0.000818713,
-0.011198526,
-0.02222364,
0.000011685106,
-0.02079631,
-0.01808839,
-0.0038284422,
0.0383111,
0.0035583167,
0.012145633,
0.007756931,
0.027092565,
0.029587055,
0.010758323,
0.017821599,
-0.014126551,
0.020102656,
0.0065730484,
-0.0047955574,
0.014766848,
0.02193017,
-0.010324788,
0.039191507,
0.031027723,
0.008103758,
0.016847814,
0.00088624435,
0.023917759,
-0.034549356,
0.0035883307,
-0.015060318,
0.035856627,
0.00917759,
0.037617445,
0.0047255247,
-0.0002223948,
-0.0037384003,
-0.012719232,
0.005252436,
-0.015060318,
0.0017107934,
-0.013512934,
-0.009631133,
-0.019075513,
0.017301356,
0.031748056,
0.03140123,
-0.008483934,
-0.003146459,
0.0025711923,
0.004518762,
0.01499362,
-0.018795382,
-0.015020299,
0.020676255,
0.011051792,
0.016967868,
0.025411785,
-0.003778419,
0.0031297847,
-0.022437071,
0.032601785,
0.008790744,
0.019328963,
0.014339983,
0.0089975055,
-0.006099495,
0.0238644,
-0.009584445,
0.020516181,
0.0014506727,
-0.021356571,
0.0432734,
0.003861791,
-0.0014540076,
-0.013392878,
-0.003414917,
-0.0015698947,
-0.02028941,
0.007576847,
0.004932287,
0.03465607,
0.013579631,
0.012352395,
-0.0087040365,
0.018795382,
-0.015046978,
0.0067898156,
-0.015487182,
-0.02194351,
-0.01835518,
-0.009837896,
0.018902099,
-0.009097552,
-0.016727757,
-0.0037950934,
0.01276592,
-0.0051990775,
-0.0006969899,
0.0074167727,
-0.024064492,
0.012739241,
0.0056759655,
-0.011958879,
-0.018155087,
0.024371302,
0.0030297383,
-0.00805707,
-0.030067276,
0.0005044006,
0.0047021806,
-0.018381858,
-0.0017224655,
0.015460503,
0.0017308027,
-0.0021843463,
-0.0042953254,
-0.0040318696,
-0.009090883,
0.016194176,
-0.009277636,
-0.0060961605,
0.014219928,
0.00086123275,
0.00039914344,
-0.020863008,
-0.008063739,
0.017754901,
0.009250957,
-0.0053224685,
-0.00250116,
-0.018061709,
0.016567683,
0.006299588,
-0.02585199,
-0.0032998635,
0.017368054,
0.002387774,
0.019222248,
-0.02693249,
-0.009304315,
0.01554054,
-0.011071801,
-0.01918223,
-0.021663379,
-0.006603062,
-0.0074634613,
0.055705834,
-0.003691712,
-0.007390094,
0.025104975,
0.0146334525,
-0.00861066,
-0.01862197,
-0.041512586,
0.0016049109,
0.02080965,
-0.0025528506,
-0.0075701773,
0.02026273,
0.00777694,
0.013546282,
0.02193017,
-0.011265224,
-0.029827166,
-0.0033082007,
0.021343231,
0.007836968,
-0.008950817,
0.001777491,
0.02835982,
0.02585199,
-0.016847814,
0.014606774,
0.01222567,
-0.0035950006,
-0.0099913,
-0.0017458096,
0.002551183,
-0.014206588,
0.013286161,
0.0060127885,
-0.009130901,
0.010238081,
-0.02606542,
0.0030414104,
-0.024771487,
0.016047442,
0.02331748,
-0.0018341839,
-0.0023594275,
0.00971784,
-0.017274678,
-0.007043266,
-0.00915758,
-0.021823455,
-0.01584735,
0.030760933,
0.005492547,
-0.003921819,
-0.019529056,
0.0004427053,
0.025425125,
0.020102656,
-0.003271517,
-0.02107644,
-0.023117388,
-0.037110545,
-0.015233731,
0.020889688,
-0.0013481252,
-0.029480338,
-0.019582415,
0.0074768006,
-0.013552952,
-0.030867647,
-0.016460966,
-0.0033298775,
-0.055705834,
-0.004061884,
-0.00582937,
0.010891718,
0.0065030158,
0.027346015,
-0.022063565,
0.0083705485,
-0.0036750375,
-0.004518762,
0.011065131,
0.020356108,
-0.012005568,
-0.002065958,
0.025678575,
0.021783436,
0.0016515993,
-0.013446236,
-0.027719522,
-0.0024761483,
-0.007350075,
0.03108108,
-0.010144705,
-0.012966013,
0.01939566,
0.00038934723,
0.007610196,
-0.010044659,
-0.028253103,
0.006029463,
-0.03465607,
-0.01193887,
-0.0222103,
0.013899779,
-0.009257627,
-0.010398155,
-0.0087040365,
-0.020476162,
-0.009531086,
-0.019662451,
-0.016714418,
0.033055328,
0.010464853,
0.021089781,
0.027119244,
0.01751479,
-0.012619185,
0.0073367357,
-0.008503944,
-0.0093309935,
0.0007249195,
0.0055425703,
0.015487182,
-0.016874492,
0.028119707,
0.0057493327,
0.007970363,
-0.0316947,
-0.026318872,
-0.0039351583,
0.044367243,
0.01720798,
-0.00017383062,
-0.0046988456,
-0.03388238,
-0.01830182,
-0.016727757,
-0.024384642,
-0.009517747,
0.0034315914,
-0.008937478,
0.004505423,
-0.022650504,
0.007556838,
-0.019382322,
0.0018308491,
0.020596217,
-0.016994547,
0.019048834,
0.012665873,
-0.0063229324,
-0.010444844,
-0.017154623,
-0.008990836,
-0.013512934,
-0.011011774,
0.013272822,
0.01720798,
0.00888412,
0.022357035,
-0.017821599,
0.017954994,
0.011838824,
0.015127015,
0.007997042,
0.021436607,
-0.00073283986,
-0.0305475,
-0.004692176,
0.021596681,
0.0067898156,
-0.0099579515,
-0.0030864314,
0.012579167,
-0.0034549355,
-0.024171209,
-0.012259019,
-0.005339143,
-0.02470479,
-0.021156479,
0.008630669,
-0.007163322,
0.019475698,
-0.02942698,
0.00917092,
0.05028999,
-0.022917295,
0.028199743,
-0.010911727,
0.009571105,
0.000029727327,
0.020903027,
-0.018822063,
-0.002926357,
-0.011952209,
0.00722335,
-0.021890152,
0.0018141747,
0.013993156,
-0.0027662828,
0.005172399,
-0.0030347407,
0.012459111,
0.0077836094,
0.018501913,
0.0012305707,
0.007910335,
0.0069765686,
-0.005909407,
-0.0033682287,
-0.014273286,
-0.020462822,
-0.020636236,
0.00067156146,
0.00081621186,
0.011812145,
0.018555272,
-0.036150098,
-0.013139427,
-0.0031297847,
-0.013299501,
0.029480338,
-0.010044659,
0.035056256,
0.014219928,
0.01305939,
-0.023024011,
0.003233166,
0.0021326556,
-0.014913583,
0.022623826,
-0.010044659,
-0.020582879,
-0.04530101,
0.040125273,
0.015753973,
-0.0013081066,
-0.015207052,
0.039911844,
0.010704964,
-0.015700614,
-0.024744809,
-0.008970827,
-0.025598537,
0.034576036,
-0.0004281152,
-0.0077902796,
0.0069032013,
-0.0052290917,
-0.0065697134,
0.011958879,
-0.008990836,
0.022090245,
-0.021503305,
-0.007196671,
0.0044487296,
-0.036576964,
-0.017541468,
-0.0015757307,
0.018061709,
0.009411031,
-0.0027662828,
-0.0080504,
0.0016307563,
0.022410393,
-0.0003105607,
0.001762484,
-0.0023927763,
0.036390208,
-0.008657348,
-0.0120856045,
-0.00030764268,
-0.002747941,
0.013766384,
-0.0007595189,
-0.0097045,
-0.018555272,
0.0059761046,
-0.0012597509,
0.026518965,
0.01746143,
-0.01584735,
-0.0051790685,
-0.02803967,
0.009244287,
-0.014393342,
-0.020356108,
0.014486718,
-0.026292194,
-0.0060661463,
0.011852163,
-0.015327108,
0.031054402,
0.016274214,
0.010618257,
-0.015994083,
0.019742489,
-0.02358427,
-0.004525432,
0.03193481,
0.019102192,
-0.024918223,
0.0099913,
-0.02466477,
-0.017328035,
0.009364342,
-0.02000928,
-0.021209836,
-0.025438463,
-0.014940262,
0.0112518845,
-0.026265513,
-0.028226424,
0.007863646,
0.014793527,
-0.0012322381,
-0.025785292,
0.0015298761,
0.04159262,
-0.0040452094,
0.003521633,
0.027559448,
-0.015713954,
0.0035383075,
-0.0277462,
0.020702934,
0.005766007,
-0.024878204,
-0.012792599,
-0.00025136658,
0.02998724,
-0.009911263,
-0.0032081543,
0.014793527,
-0.017448092,
-0.0146334525,
0.007270038,
-0.005779347,
-0.00054650346,
0.0048989384,
0.0038151026,
-0.016527664,
-0.0014039844,
0.0013948135,
0.008917469,
0.0075835166,
-0.022877276,
-0.038577892,
0.007823628,
-0.0227839,
0.045327686,
0.011558694,
-0.013699686,
-0.011532014,
-0.020035958,
-0.04660828,
-0.011485326,
-0.012292367,
0.0032615126,
0.008810753,
0.020756293,
0.021836793,
0.012592507,
-0.0013081066,
0.012305707,
-0.02526505,
-0.008737385,
0.00011432385,
-0.010178054,
0.01638093,
0.010238081,
-0.04610138,
-0.0060394676,
0.017794918,
0.0038651258,
0.0089975055,
0.013312841,
-0.01583401,
0.0054158447,
-0.014753508,
0.002861327,
-0.0072366893,
-0.0045954646,
0.0067297877,
-0.020329427,
-0.018782044,
-0.008910799,
-0.012639195,
0.0041752695,
-0.019328963,
0.009344334,
0.0060928254,
0.009864574,
-0.012679214,
0.0023911088,
0.012819278,
-0.028146386,
0.011291903,
0.0062495647,
-0.0091642495,
0.0006686434,
0.0033382147,
-0.009944612,
-0.019315625,
-0.0060661463,
-0.014913583,
0.01808839,
-0.0013406217,
-0.009324324,
0.011338592,
-0.030013919,
0.0036416887,
-0.015500521,
0.011838824,
-0.008350539,
-0.0260921,
-0.01642095,
0.021596681,
0.024531376,
-0.009217608,
-0.009184259,
0.008637339,
-0.010371476,
-0.029960562,
-0.0051757335,
0.009757859,
-0.008243823,
0.024584735,
-0.000082538274,
-0.0067331223,
0.0039818464,
0.012619185,
0.0054025054,
-0.023477554,
0.020516181,
0.17949657,
-0.001137194,
0.019729149,
0.017648185,
-0.034202527,
0.011291903,
0.02972045,
0.015954066,
0.015046978,
0.016287554,
0.012412423,
0.003081429,
-0.007043266,
0.0028813363,
-0.0104982015,
-0.017127942,
-0.024798166,
-0.005028999,
-0.009057534,
0.023517573,
0.018381858,
-0.0056292773,
-0.042713143,
-0.007376754,
0.014566755,
0.009851235,
-0.008684027,
0.0049156127,
0.008804083,
-0.014113212,
-0.0030680895,
0.0031831427,
-0.011065131,
-0.0001633049,
-0.011278564,
-0.0025044947,
0.0067264526,
0.0067531317,
0.008844102,
0.023931097,
0.0003397409,
0.012265688,
-0.0040418743,
-0.031561304,
-0.009224278,
0.009837896,
0.0062062116,
-0.008744055,
-0.007136643,
-0.0076302052,
-0.025104975,
-0.02169006,
-0.020903027,
0.010764992,
-0.0073700845,
-0.00721668,
0.023824383,
-0.00861066,
-0.00749681,
0.024624754,
-0.0058760582,
0.008517283,
-0.016220856,
-0.00020301082,
-0.032334995,
0.05752001,
-0.022797238,
0.002819641,
-0.020516181,
-0.0069165407,
0.009024185,
-0.023290802,
-0.023904419,
-0.0017724887,
-0.007056606,
-0.010218072,
0.034629393,
0.022943974,
0.027559448,
0.006603062,
0.0006623905,
-0.0046988456,
-0.0050089895,
0.00680649,
-0.02610544,
-0.040498782,
0.035883307,
0.014540076,
-0.04193945,
0.0022610486,
-0.0022293671,
0.0071433126,
0.0013331182,
-0.0012930997,
0.010204732,
-0.0037017167,
0.022850597,
-0.002819641,
-0.012232339,
-0.007903665,
-0.010338128,
0.0683517,
0.009210939,
0.0061561884,
0.0005206581,
0.024277925,
-0.0042953254,
0.010731643,
-0.0010546558,
0.0034182519,
0.017714882,
-0.031988166,
0.021209836,
-0.0062028766,
0.015313769,
0.00079245085,
0.016834473,
-0.011231875,
0.013913119,
0.008684027,
-0.0123790745,
-0.019529056,
-0.012098944,
0.023544252,
-0.02830646,
-0.03222828,
-0.030013919,
0.016527664,
-0.006556374,
-0.0034649402,
-0.005996114,
-0.037537407,
0.0071299733,
-0.008650678,
-0.0014339983,
-0.005779347,
-0.006139514,
-0.020049298,
0.011505336,
0.0052057477,
0.01722132,
-0.016887832,
0.019875884,
-0.0016240865,
-0.016607702,
-0.010618257,
0.021529984,
0.028679967,
-0.00012662122,
-0.0015465505,
-0.015020299,
-0.041005682,
-0.0080370605,
-0.0042886557,
0.041726016,
-0.009944612,
-0.0060127885,
-0.02942698,
0.0080504,
0.0065963925,
-0.020716274,
0.020222712,
0.026585663,
-0.02167672,
-0.008757395,
0.028679967,
-0.17021227,
-0.00017737392,
0.022357035,
-0.028786683,
0.025158335,
0.012679214,
0.008904129,
0.0021276535,
-0.015487182,
-0.007049936,
0.018688668,
0.011118489,
-0.042072844,
-0.004075223,
0.022397052,
0.02637223,
-0.021156479,
0.034042455,
0.02110312,
0.011445308,
0.03300197,
-0.017981673,
0.009357673,
-0.022397052,
0.006803155,
0.016394269,
-0.021183157,
0.0066764294,
0.0020642907,
-0.03142791,
-0.02000928,
0.006696439,
0.043940376,
-0.010785001,
0.019809186,
-0.01471349,
-0.026212156,
-0.0072300197,
-0.013793063,
0.0017474771,
0.028146386,
0.013159436,
-0.0032281638,
0.018288482,
-0.028920079,
0.008170456,
0.0029780478,
-0.00013475,
0.010891718,
0.0017874956,
-0.010031318,
-0.007950353,
0.012725902,
-0.0022460415,
0.012292367,
0.0027145923,
0.001989256,
0.015887368,
0.021276534,
-0.019995939,
-0.013566291,
-0.02554518,
0.027065884,
-0.028253103,
0.009270966,
-0.02165004,
-0.019675791,
0.018128406,
0.007743591,
0.009971291,
-0.02747941,
-0.0048922687,
0.00008274671,
-0.014193249,
0.014980281,
0.0072033405,
-0.018541932,
-0.0054491935,
0.0044787438,
-0.015500521,
-0.021770095,
0.0322016,
-0.007917005,
0.015233731,
-0.005769342,
-0.0091242315,
0.00059652666,
0.020943046,
-0.00044437274,
-0.0031131103,
0.021730077,
-0.02585199,
0.01222567,
-0.03804431,
0.026252175,
0.017688204,
0.004775548,
-0.0054158447,
0.01388644,
0.008357209,
0.017034566,
-0.009371012,
-0.015353787,
0.0108783785,
0.026799094,
-0.009364342,
-0.00018227202,
-0.003009729,
0.041299153,
0.008570641,
-0.021516645,
-0.022183621,
0.0031931475,
0.0017274678,
-0.018648649,
0.018395197,
-0.007196671,
-0.01417991,
0.0061428486,
-0.011405289,
0.037910916,
-0.021756757,
-0.0027396039,
-0.0016707748,
-0.0057359934,
-0.0069899084,
-0.12197657,
0.013966477,
0.0076502142,
0.0018975467,
-0.015780652,
0.019048834,
-0.0074634613,
0.01638093,
-0.009017515,
0.028920079,
-0.0505301,
0.0035116286,
-0.003206487,
-0.0059560956,
0.019475698,
0.01638093,
0.0045387717,
-0.0012330718,
0.0011230208,
0.04073889,
0.0021576672,
-0.0277462,
0.0050456733,
0.00722335,
0.017234659,
-0.0013773054,
-0.019075513,
0.0062862486,
-0.018902099,
0.007350075,
0.014820206,
-0.024771487,
-0.0001091131,
-0.022903955,
-0.03633685,
0.003361559,
-0.020996403,
-0.0166744,
0.0047622086,
-0.01305272,
0.009230947,
0.0155938985,
0.019475698,
0.012025577,
0.016714418,
-0.0058193654,
-0.014660132,
0.0140064955,
-0.003358224,
-0.033402156,
-0.030600857,
-0.021583343,
-0.018435216,
-0.00541251,
-0.00777694,
0.0034099147,
-0.007530159,
0.009244287,
0.015100336,
0.008644009,
0.01248579,
-0.01778158,
-0.019742489,
0.013286161,
0.019769168,
-0.013979817,
-0.026212156,
-0.012339056,
-0.0010021314,
-0.0067831455,
-0.01583401,
0.007856977,
-0.0015023634,
-0.007917005,
-0.041512586,
0.0028329804,
-0.010891718,
-0.003665033,
0.005882728,
-0.006016123,
-0.0048122318,
-0.021810114,
0.000565679,
-0.02441132,
0.04663496,
0.029533695,
0.00089458155,
-0.0077902796,
0.007556838,
-0.007850307,
-0.0152604105,
0.00637629,
-0.0039351583,
-0.026612341,
0.013312841,
0.016541004,
-0.0007907834,
-0.015100336,
0.015954066,
-0.0019258931,
-0.02693249,
-0.012479121,
-0.05138383,
0.02167672,
0.0041686,
-0.0015132017,
0.0030864314,
-0.002736269,
0.04223292,
0.0142999645,
0.00076202006,
0.01555388,
-0.0003218159,
0.0019525721,
-0.02525171,
0.013366198,
-0.018221784,
-0.025918687,
-0.008417237,
0.025731932,
0.026492286,
0.019355644,
-0.012865966,
0.02747941,
0.013979817,
0.012825948,
0.0031297847,
-0.012172312,
0.0054625333,
0.018475235,
-0.017288018,
0.0015974075,
-0.0043720277,
-0.011598712,
-0.01442002,
0.015567219,
-0.0036216795,
-0.009891254,
0.022143602,
0.028920079,
0.04164598,
0.03238835,
-0.032628465,
0.0035749911,
0.018915439,
-0.005519226,
-0.0047622086,
0.0067497967,
-0.001193887,
0.010791671,
-0.0041752695,
-0.0015440494,
0.03724394,
-0.00073909276,
-0.013619649,
-0.014193249,
-0.018461894,
-0.011998897,
0.014460039,
0.0027529434,
0.0027396039,
-0.030360747,
0.03470943,
0.010791671,
0.0037584095,
-0.002721262,
0.0019509047,
-0.012972683,
-0.023744345,
0.013913119,
-0.00080495665,
-0.019489039,
-0.015687276,
-0.027879596,
-0.008764064,
0.011485326,
0.0031164452,
0.0010855034,
0.017034566,
0.015940726,
0.021089781,
0.0053157983,
0.005852714,
-0.009317654,
-0.025958706,
0.02136991,
0.007923675,
0.025865328,
-0.007937014,
0.018208444,
-0.024384642,
0.0222103,
-0.011598712,
0.027612805,
0.0073967637,
-0.00041644313,
-0.00777027,
0.012559158,
0.009671152,
0.017741561,
0.034842826,
0.045167614,
0.019302284,
0.0023677647,
0.010064667,
-0.036150098,
-0.012025577,
0.01472683,
-0.018808722,
-0.035243012,
0.013753044,
0.012592507,
0.010104686,
0.007983702,
-0.011565363,
-0.005195743,
0.0037250607,
0.0064830063,
0.018461894,
-0.0068431734,
-0.036496926,
0.0023961111,
-0.0021509975,
0.024531376,
-0.022343695,
-0.02886672,
0.0008374717,
0.0027729527,
0.016020764,
-0.013132757,
0.02585199,
-0.026892472,
0.012445772,
0.027559448,
-0.013793063,
-0.017061245,
-0.009064203,
-0.015673935,
0.017061245,
0.010544891,
-0.00020165602,
0.07710242,
0.003778419,
0.0008053735,
0.012245679,
-0.03607006,
0.0083705485,
0.0014415018,
0.018581951,
-0.002959706,
-0.045914628,
0.018061709,
-0.0031481266,
0.02169006,
-0.037163902,
-0.042072844,
0.019595753,
-0.012992692,
0.02835982,
-0.023010671,
-0.0049856454,
0.032334995,
-0.0032815218,
0.030013919,
0.0013798065,
-0.030414104,
-0.003801763,
0.034309246,
-0.0041019022,
0.0013589635,
-0.030947685,
-0.015927386,
-0.00075576716,
-0.024357963,
-0.011892182,
-0.014406681,
-0.016007423,
0.00021989364,
-0.034869503,
0.011458647,
0.005172399,
0.0061661927,
0.013793063,
-0.021730077,
-0.029933881,
-0.001982586,
0.012185651,
-0.026972508,
-0.015207052,
-0.017834937
] |
Spatial boundaries of homeotic gene expression are initiated and maintained by two sets of transcriptional repressors: the gap gene products and the Polycomb group proteins. Previously, the Hunchback (HB) protein has been implicated in setting the anterior expression limit of the UBX homeotic protein in parasegment 6. Here we investigate DNA elements and trans-acting repressors that control spatial expression of the Abdominal-A (ABD-A) homeotic protein. Analysis of a 1.7-kb enhancer element [iab-2(1.7)] from the iab-2 regulatory region shows that | [
-0.028445529,
-0.008973887,
0.0073619736,
-0.02062978,
-0.034757726,
0.0143311275,
-0.008499795,
0.002654916,
0.003782578,
-0.022458421,
0.014778129,
-0.011527211,
0.0055671963,
0.013321989,
0.0036064866,
0.00020508718,
0.022241693,
-0.006701631,
-0.0046968986,
0.030748261,
-0.004558057,
0.01867923,
-0.0066914717,
-0.021618601,
-0.023325333,
0.011235984,
0.02309506,
-0.029989714,
-0.00033313438,
-0.027375434,
0.0070978366,
0.016349405,
-0.013525171,
0.015333494,
-0.01354549,
0.00085421244,
-0.0068607903,
-0.024612155,
0.028824802,
0.008195021,
0.02642725,
0.014195673,
-0.01853023,
-0.0065356987,
-0.006593267,
0.0037758052,
-0.010490982,
-0.014155037,
-0.021185145,
0.014872948,
-0.0072874734,
0.028120436,
-0.039092284,
-0.0024517337,
0.00029927067,
0.0047781714,
0.021049691,
0.026562706,
-0.0005007598,
0.00074500195,
-0.005174377,
0.008479477,
-0.0051134224,
0.0008889228,
-0.016864134,
0.021158054,
-0.0010997244,
-0.023677515,
0.019044958,
-0.011059892,
0.036139365,
0.025072701,
-0.012367032,
0.004541125,
0.0279308,
-0.020115051,
-0.013708035,
0.0060446747,
-0.0381441,
0.01663386,
0.0147510385,
-0.0017211238,
-0.0025668703,
0.01892305,
0.02879771,
-0.0055976734,
0.005191309,
0.01867923,
0.01978996,
-0.005699265,
0.017216317,
0.021699874,
0.014818765,
-0.0061699706,
-0.03296972,
0.0014798447,
-0.0010370766,
0.029420804,
-0.011439166,
-0.023216968,
-0.021632146,
-0.0064171758,
-0.044483386,
-0.009109342,
-0.011175029,
-0.004100897,
0.004209261,
-0.008039248,
0.009915299,
-0.020562053,
-0.035272453,
0.024788246,
0.0031510196,
-0.025208157,
0.008106976,
-0.046786122,
0.011689758,
0.014439492,
-0.010504527,
-0.0111208465,
0.007267155,
0.027876617,
-0.004893308,
-0.03427009,
0.028012073,
0.017405953,
-0.0032678493,
0.0070436546,
-0.014425946,
-0.030558625,
0.013680944,
0.016241042,
0.0127869425,
0.02033178,
-0.019966051,
-0.015726313,
-0.018895958,
-0.034378454,
-0.002436495,
-0.04488975,
0.006769358,
0.019830598,
-0.017202772,
0.0015721234,
0.012021622,
0.008723295,
0.016132679,
0.016092042,
0.020954872,
0.014087309,
0.000329748,
-0.0046968986,
0.008669114,
-0.003846919,
0.018354138,
0.0076802927,
-0.010294572,
0.015631495,
-0.012035168,
-0.010626436,
-0.0059396974,
0.0059261518,
0.005421582,
0.016390042,
0.01991187,
0.019153323,
-0.0064442665,
-0.011886167,
-0.014994857,
-0.010518073,
-0.015252221,
0.012306077,
-0.04345393,
-0.0077344747,
-0.0024161767,
0.004710444,
-0.008526886,
0.019085595,
-0.03955283,
-0.022648059,
-0.023474334,
0.00407042,
0.005912606,
0.023772335,
-0.0069352905,
-0.003884169,
0.014588492,
-0.011324029,
0.011913258,
-0.017311135,
0.005265809,
0.01630877,
0.023474334,
0.011784576,
-0.63241184,
0.0050592404,
0.014737492,
-0.041611742,
0.012915624,
0.03597682,
0.011235984,
0.007612565,
-0.010680619,
0.026224067,
-0.014981312,
0.027023252,
0.030043896,
-0.008228885,
-0.023826515,
-0.02396197,
0.003310179,
-0.03762937,
0.03795446,
0.017758137,
-0.0056552417,
-0.003091758,
0.00033482758,
0.038902648,
0.0067625856,
0.022295875,
0.036437366,
-0.016850589,
-0.011520439,
0.01189294,
-0.018665684,
0.031642262,
-0.0151574025,
0.012407669,
0.053206682,
0.018543776,
-0.013274579,
0.015753405,
0.0051879226,
0.037493914,
0.0023450628,
-0.014615583,
0.028391346,
0.0049610357,
-0.022580331,
0.0068336995,
0.017405953,
0.00890616,
0.01825932,
-0.024300609,
-0.022024967,
0.0015636574,
-0.0006967461,
-0.00044996422,
0.01312558,
0.005157445,
0.035760093,
0.00084151357,
0.017040227,
-0.013437126,
0.013565808,
0.02877062,
-0.010125253,
0.0035624637,
0.0025126883,
0.0086420225,
0.0008728375,
0.0033067926,
0.0064984486,
0.00905516,
0.014087309,
0.027104525,
-0.0056213783,
0.019505505,
0.03375536,
0.05754124,
0.0029427577,
-0.007429701,
-0.0009574968,
0.01438531,
0.0044124434,
0.011804895,
-0.04727376,
0.004717217,
0.01897723,
-0.017825864,
-0.04486266,
0.031073352,
-0.00330002,
-0.026860707,
0.017663319,
-0.0020148915,
-0.017487228,
-0.023948425,
-0.012346714,
0.015455403,
-0.0057500605,
0.01880114,
0.010992165,
-0.019288776,
-0.012996897,
-0.0137689905,
0.0069420636,
-0.005194695,
0.00031599088,
0.009420888,
-0.0069081997,
0.010226845,
0.019884778,
-0.009522479,
-0.014791675,
-0.0034947363,
-0.017974865,
-0.0020792326,
-0.011594939,
-0.032075718,
0.01895014,
-0.006667767,
-0.02198433,
-0.030694079,
-0.003684373,
-0.010951528,
0.006298653,
-0.014913584,
0.010247163,
0.01729759,
0.008005384,
-0.012285759,
-0.0007115615,
0.0062241526,
0.028635165,
-0.013213625,
0.019437777,
-0.015184494,
0.019993143,
0.00487299,
0.032752994,
0.007355201,
0.01643068,
-0.030531533,
-0.023447242,
-0.013139125,
0.00075304456,
-0.005011831,
-0.0107618915,
-0.022024967,
-0.018299956,
-0.010470663,
0.024422517,
0.0146426745,
0.02048078,
0.0024686654,
-0.0013045999,
0.012570214,
0.017527863,
-0.014778129,
-0.0022756422,
-0.018354138,
-0.0052421046,
-0.008723295,
0.008269521,
0.007314564,
-0.003664055,
-0.011330802,
-0.02682007,
-0.011716848,
0.004121215,
0.008323703,
-0.0037690324,
-0.024341244,
0.0013266114,
-0.03678955,
-0.020209871,
-0.008425294,
-0.0012402589,
-0.004663035,
-0.00023831596,
-0.0011691451,
-0.003674214,
-0.025153974,
0.0017643,
-0.006346062,
-0.017636226,
-0.020792326,
0.04421248,
0.00890616,
0.023569152,
0.015753405,
0.0127869425,
0.01561795,
-0.016213952,
0.018015502,
-0.017189227,
0.031181717,
-0.0049068537,
-0.018218683,
0.02435479,
0.022228148,
-0.0034981228,
0.042153563,
0.023921335,
-0.030206442,
0.00034096537,
-0.02243133,
0.009928844,
-0.040067557,
-0.010192981,
-0.019180413,
-0.025709338,
-0.012062258,
0.014290491,
0.004385352,
0.00076912984,
-0.0075719287,
0.013159443,
-0.0054249684,
-0.023284696,
0.0097324345,
-0.009163524,
0.0014823845,
-0.0039146463,
-0.0001450849,
0.020873599,
0.015875313,
-0.022417786,
-0.0003327111,
-0.0009930537,
0.006647449,
0.0076735197,
-0.013376171,
0.0213206,
0.013267807,
-0.0042228065,
0.0074771103,
0.010362299,
0.011676212,
0.0211716,
-0.0073619736,
0.043345567,
0.0036674412,
0.005299673,
0.0019657891,
0.0030782125,
0.006176743,
0.010646755,
-0.00878425,
0.029529167,
-0.0031493264,
-0.016796406,
0.01798841,
-0.00037990866,
0.005174377,
-0.005729742,
0.008763932,
0.012353486,
-0.018503139,
0.010402936,
0.008919705,
0.049766127,
0.0099830255,
-0.00044869434,
0.0026142795,
-0.02573643,
-0.012333169,
0.018056137,
0.007429701,
-0.00989498,
-0.007104609,
-0.02516752,
0.00732811,
-0.00019757367,
0.002517768,
-0.006230925,
-0.019234596,
0.010531618,
0.007172337,
-0.018557321,
0.015807586,
0.02006087,
0.018733412,
-0.005858424,
-0.04559412,
0.02963753,
0.027402526,
-0.011452711,
0.0028123823,
-0.021523783,
0.0023704607,
-0.0018167888,
0.023054423,
0.015509586,
0.00421942,
0.021374783,
-0.00280053,
0.00059430837,
0.008039248,
0.006474744,
-0.00433117,
0.002218074,
-0.0050253766,
-0.0018794367,
-0.008391431,
-0.018570866,
-0.00414492,
0.05420905,
0.01480522,
0.012109668,
-0.018760502,
-0.014141491,
-0.019966051,
-0.002201142,
-0.0010125253,
0.0014087309,
0.008973887,
0.0018388003,
-0.010951528,
-0.011384984,
0.00075389113,
0.028174618,
-0.0004436148,
-0.03432427,
-0.034974456,
-0.006738881,
0.012692124,
0.03819828,
0.015550222,
-0.015049038,
0.025194611,
-0.0064882897,
0.008851977,
-0.028878983,
-0.021889511,
0.0049373307,
-0.015875313,
-0.004764626,
0.0044971025,
0.009305751,
-0.009773071,
-0.0035895547,
0.008059566,
0.007226519,
-0.037223004,
-0.016715134,
0.005028763,
-0.020941326,
0.0035218273,
0.0074635646,
0.049061764,
0.018218683,
-0.010450345,
0.010538391,
0.015604404,
0.0125228055,
-0.018245775,
-0.014615583,
0.01744659,
0.013030761,
0.008303385,
0.00629188,
-0.029718803,
0.015035493,
-0.007808975,
0.0025516315,
0.007219746,
0.021212237,
0.025655158,
0.014859402,
-0.020521417,
-0.003664055,
-0.0037521005,
-0.019871233,
0.022187512,
-0.024124516,
-0.031371355,
0.0024348018,
-0.027321253,
0.009136433,
-0.017514318,
0.009393797,
-0.048357397,
-0.0016923395,
-0.014832311,
0.011263074,
-0.027768254,
-0.006681313,
-0.023203423,
0.028851893,
-0.016931862,
-0.0012309464,
-0.021130964,
-0.014263401,
-0.019437777,
-0.011032801,
-0.016227497,
-0.004981354,
-0.02961044,
-0.023474334,
0.00491024,
0.027009707,
0.026508523,
0.030179352,
-0.018936595,
-0.014737492,
-0.012028394,
-0.000093019415,
-0.020589145,
0.00052361784,
-0.02795789,
0.004158465,
-0.01315267,
0.014344674,
-0.020318234,
0.006728722,
0.0003830834,
-0.007138473,
-0.013172989,
0.020087961,
-0.0075312923,
-0.002063994,
0.0060277428,
0.016918316,
0.028960256,
0.013274579,
-0.01139853,
-0.01196744,
-0.015211585,
-0.008479477,
-0.021645693,
0.009725662,
-0.014358219,
0.0053978777,
0.008763932,
-0.017582046,
-0.0149542205,
-0.005821174,
-0.025953159,
-0.01204194,
-0.0126785785,
0.025153974,
0.018381229,
0.0071317004,
0.0175685,
-0.022851242,
0.010125253,
0.005140513,
-0.002983394,
0.008743614,
0.003636964,
-0.038442098,
0.038821373,
-0.005736515,
-0.029393712,
-0.016769316,
0.0021672784,
-0.0128817605,
0.05624087,
0.0072874734,
-0.015875313,
-0.023745243,
-0.0035793956,
-0.004828967,
0.0076802927,
0.003200122,
-0.01127662,
-0.0076261107,
0.00043853524,
0.016891226,
-0.026115704,
0.004172011,
-0.029718803,
-0.0051980815,
0.019356504,
-0.0004948337,
0.004757853,
0.0030206442,
0.018354138,
0.0031764172,
-0.0013359239,
-0.024761155,
-0.049115945,
-0.0029681553,
-0.010490982,
0.03594973,
0.022539694,
0.0387401,
0.016200405,
0.013118806,
0.04125956,
0.0128817605,
0.0013452364,
-0.0033372699,
0.022661604,
-0.021794694,
0.019803505,
-0.009671479,
0.0005917686,
0.024571517,
0.0055502644,
0.015658585,
0.03990501,
-0.012841124,
0.0042329654,
0.031967357,
-0.035082817,
-0.032021537,
0.005421582,
-0.0030392692,
0.0014366684,
-0.05564487,
-0.00407042,
0.027158707,
0.022918968,
-0.004371807,
0.0066576083,
0.027361888,
-0.011527211,
0.03597682,
0.010470663,
0.013978945,
-0.02360979,
-0.0058618104,
0.008851977,
-0.023189878,
0.023487879,
0.0006112402,
0.015049038,
-0.022593876,
-0.016024314,
-0.007118155,
0.005929538,
-0.00018889608,
0.004974581,
-0.014168582,
-0.012136758,
-0.004974581,
-0.02396197,
-0.020033779,
-0.039715376,
-0.010619664,
0.010741573,
-0.02375879,
0.03240081,
0.003782578,
-0.028689347,
0.031208808,
-0.00082627486,
0.03733137,
-0.007876703,
0.022661604,
0.031181717,
0.0057602194,
-0.015509586,
-0.015401222,
-0.009312524,
0.010951528,
0.028418437,
0.015292858,
0.0031577921,
-0.005319991,
0.009007751,
0.017744591,
-0.018042592,
-0.040338468,
0.0036268048,
-0.014886493,
0.002900428,
0.00019609212,
0.0056416965,
0.0017829251,
-0.018665684,
-0.016037859,
0.012705669,
-0.011520439,
-0.009041614,
-0.00858784,
-0.014994857,
-0.0016110666,
-0.011249529,
0.01813741,
-0.0035489183,
-0.004510648,
-0.0076870653,
0.006318971,
-0.0013723274,
-0.0010209912,
0.023731697,
-0.013680944,
0.018340593,
0.021686329,
0.011811667,
-0.004209261,
0.0018658912,
-0.0042024883,
0.037195913,
-0.04616303,
-0.035516273,
-0.005966788,
-0.0044666254,
0.028987348,
-0.0023128923,
-0.0011208892,
-0.034080453,
-0.0039383513,
-0.007091064,
0.009183842,
0.013139125,
0.010375845,
-0.009380251,
-0.012035168,
-0.001627152,
-0.02366397,
-0.021794694,
0.009021296,
-0.048790853,
-0.009955935,
-0.007355201,
0.0064882897,
0.022336513,
0.0042431247,
0.0034676453,
-0.010937983,
0.010098162,
-0.02738898,
0.02465279,
-0.006302039,
0.0028259277,
-0.02640016,
0.019085595,
-0.0063900845,
-0.021307055,
0.01162203,
-0.025221702,
0.01223835,
0.000010350924,
-0.011147938,
0.015821131,
0.01438531,
-0.01522513,
0.014466583,
-0.013531944,
0.0213206,
-0.0091567505,
0.006928518,
0.012285759,
-0.0048966943,
0.027348343,
0.014195673,
-0.004757853,
0.0147510385,
-0.016918316,
-0.006769358,
0.015049038,
-0.016715134,
-0.009007751,
-0.01966805,
0.019017868,
0.015428313,
-0.0029952463,
-0.020873599,
-0.009718888,
-0.011046346,
0.023826515,
0.0024568131,
0.0031323945,
-0.0054689916,
0.011581394,
-0.024016153,
-0.0005159985,
-0.020209871,
0.0003208588,
0.011506894,
-0.02630534,
-0.055048868,
-0.005248877,
-0.010646755,
0.049143035,
0.016037859,
-0.03494736,
-0.00043282073,
0.0027785185,
-0.03600391,
-0.021347692,
0.01016589,
0.011235984,
-0.009420888,
0.01093121,
-0.0059396974,
0.01204194,
0.007917339,
0.03264463,
0.013796081,
-0.019681597,
0.020372417,
-0.007971521,
0.013010443,
0.0028360868,
-0.02765989,
-0.02729416,
0.011371438,
-0.022390693,
0.0016237656,
0.03462227,
-0.022729332,
0.018421866,
-0.020115051,
0.011100529,
0.019248141,
0.0065695625,
0.015983678,
-0.025628066,
-0.0012241736,
0.015116766,
-0.0016178394,
-0.007775111,
0.018381229,
0.009617298,
0.0022434718,
0.012380578,
-0.0128343515,
-0.023487879,
0.015821131,
0.0008647948,
0.0213206,
0.018882412,
-0.0007318797,
0.01976287,
0.03329481,
-0.0012063952,
-0.024855973,
-0.013836717,
-0.0010413096,
-0.00043726535,
-0.0056891055,
-0.017934227,
-0.01361999,
-0.025235247,
-0.009590207,
-0.021781147,
0.003193349,
-0.008967114,
-0.015360585,
-0.009583434,
0.025844794,
0.010457118,
-0.0022316193,
-0.011357893,
0.0020148915,
-0.011459484,
-0.030233532,
0.023230515,
-0.013294898,
-0.025492612,
0.018056137,
-0.013850263,
-0.008540431,
0.009251569,
-0.0024314155,
-0.0019505505,
-0.015631495,
0.010619664,
0.19375469,
-0.014967766,
-0.0017592205,
-0.01438531,
0.00214696,
-0.0037419414,
0.0023586084,
0.00809343,
-0.010186208,
0.014480128,
-0.014195673,
-0.009989799,
-0.013680944,
0.00089146255,
0.02360979,
-0.037168823,
-0.01702668,
0.00079071795,
-0.027727617,
-0.004127988,
0.017053772,
-0.020115051,
0.013924764,
-0.01880114,
0.051581223,
-0.017934227,
-0.028635165,
-0.0011429007,
-0.02228233,
0.016809953,
-0.013477762,
-0.012035168,
0.0138163995,
0.00552656,
0.01576695,
0.025330065,
-0.021550873,
-0.007355201,
-0.005228559,
0.008858751,
-0.000102490674,
0.0107144825,
0.011987758,
0.011134393,
-0.0007970674,
-0.028418437,
0.010883801,
0.0019302323,
-0.0047951033,
0.0032085879,
-0.023542061,
0.029556258,
0.020534962,
0.043508112,
-0.017934227,
-0.017636226,
0.029935531,
0.003772419,
-0.0011208892,
0.032129902,
-0.00678629,
0.01828641,
-0.03299681,
-0.0032305992,
-0.022986695,
0.019139776,
-0.008147612,
0.016769316,
0.025804158,
-0.049468126,
0.022146875,
-0.0031679515,
-0.01811032,
0.0043040793,
0.0020673804,
-0.015834678,
0.014263401,
0.01258376,
0.016200405,
0.014100854,
0.019180413,
0.00032107043,
-0.027849527,
-0.007991839,
-0.0069556087,
-0.013172989,
0.040257193,
0.017365318,
-0.021659238,
-0.024151608,
0.0025042223,
-0.025804158,
-0.0019674823,
-0.013010443,
-0.0077073835,
-0.0024940632,
-0.011730394,
0.022539694,
-0.027524434,
0.0003310179,
-0.01216385,
0.040446833,
-0.0049203993,
0.0033660543,
-0.0073958375,
-0.0027531208,
-0.006034516,
-0.010111708,
0.00831693,
0.00087368407,
0.0045783753,
-0.018340593,
0.0036945322,
0.0019200732,
0.022363603,
-0.005766992,
0.023460789,
-0.016823499,
0.03516409,
-0.0053403093,
-0.005126968,
-0.018625049,
0.0074771103,
0.03567882,
0.008553977,
0.00996948,
-0.012170622,
-0.003657282,
-0.0029072007,
-0.038496282,
-0.0031002238,
-0.0051506725,
0.012590532,
0.0061631976,
0.004974581,
-0.023325333,
0.010646755,
-0.005502855,
-0.035299547,
0.02375879,
-0.01937005,
-0.0060988567,
0.026914887,
0.012069032,
0.017433045,
-0.03324063,
0.009976253,
0.016403588,
-0.009861116,
-0.01981705,
-0.014615583,
-0.003809669,
-0.008344022,
-0.015021948,
0.009752752,
-0.025451975,
-0.015536676,
-0.02156442,
0.010118481,
0.009122888,
-0.028553892,
0.015198039,
0.020101506,
-0.012969806,
-0.004266829,
-0.019139776,
-0.17197354,
0.010551936,
0.017947774,
-0.043291386,
0.00905516,
0.015116766,
0.0025025292,
-0.0018337206,
-0.018814685,
0.017744591,
0.017378863,
0.00051938486,
-0.036627002,
-0.03072117,
0.00789702,
0.011290166,
-0.02684716,
0.038875554,
0.021754056,
0.019031413,
0.0038367598,
0.0033999179,
0.029800078,
0.017514318,
0.004656262,
0.011175029,
0.00027789417,
-0.0110734375,
-0.018205138,
-0.01561795,
-0.0028767234,
0.0018472661,
0.031642262,
-0.015279313,
0.012705669,
-0.0009922071,
-0.0077073835,
0.008472703,
-0.010470663,
0.020954872,
0.003772419,
0.03592264,
-0.010795755,
0.009976253,
0.0033728268,
0.03269881,
-0.0048696036,
-0.00029842407,
0.026522068,
-0.010226845,
0.0027057116,
-0.00682354,
0.035245363,
0.02282415,
0.06360962,
-0.0023873926,
0.009434434,
0.027876617,
-0.00598372,
-0.008350794,
0.0021520397,
-0.012516032,
0.04727376,
0.005336923,
-0.009583434,
-0.0133490795,
-0.0077344747,
0.0097324345,
-0.029529167,
-0.006474744,
-0.013098489,
-0.0026261318,
0.023948425,
-0.013450671,
0.006318971,
0.028608074,
-0.008960341,
0.005993879,
-0.0074161557,
-0.0071858824,
-0.0009464911,
-0.008106976,
-0.027592162,
-0.006230925,
0.0072874734,
-0.00068362395,
-0.0032085879,
0.020236962,
0.0032136673,
-0.00821534,
0.0019894938,
0.00081823225,
0.0007005558,
0.0011911565,
0.023054423,
0.01991187,
0.005296286,
-0.02048078,
-0.011886167,
0.0024703587,
0.025099792,
-0.023298241,
-0.00097104226,
0.005892288,
0.023284696,
0.011026029,
-0.021835329,
0.009529252,
0.038415007,
-0.006034516,
0.0055062417,
-0.0063629937,
0.035109907,
0.02048078,
-0.004117829,
0.023067968,
-0.0030020191,
-0.014087309,
0.02351497,
-0.029556258,
0.055021778,
0.02738898,
-0.0070572,
0.009712116,
-0.016552588,
-0.02543843,
-0.1327458,
-0.0012808953,
0.025384247,
-0.011716848,
-0.014940675,
-0.00030096385,
-0.006948836,
0.032536265,
-0.014290491,
0.019979598,
-0.022499058,
-0.010450345,
0.009718888,
-0.025831249,
0.001810016,
0.01951905,
0.016809953,
-0.006837086,
0.01877405,
0.021239327,
-0.016417133,
0.0015255607,
-0.0033271108,
-0.008940023,
0.011357893,
-0.003164565,
-0.041097015,
0.015347039,
0.01633586,
0.0033863725,
-0.010308118,
-0.018096775,
0.023108605,
0.000720874,
-0.0016821804,
-0.036139365,
-0.004273602,
-0.00046774268,
0.03930901,
-0.018313501,
0.011737167,
-0.0052725817,
0.003173031,
-0.016742226,
0.0038875556,
-0.018029047,
0.0035421455,
0.006037902,
0.014547856,
0.00013894709,
-0.031669356,
-0.028608074,
-0.018340593,
-0.015509586,
0.019302323,
-0.0071994276,
0.009149978,
0.017514318,
-0.018381229,
0.0010057526,
-0.005543492,
0.00932607,
-0.018191593,
-0.011290166,
-0.004774785,
-0.009447979,
-0.0249237,
-0.036410276,
0.02062978,
-0.04066356,
-0.02961044,
0.031479716,
0.0075854743,
0.002990167,
-0.025018519,
0.007592247,
-0.032752994,
-0.021930147,
0.028174618,
-0.018421866,
-0.006335903,
-0.025831249,
0.028445529,
-0.040257193,
0.017094407,
0.010077844,
0.01882823,
-0.0146426745,
0.004473398,
-0.018855322,
-0.003508282,
0.036383186,
-0.002637984,
-0.0133490795,
-0.023623334,
0.014087309,
-0.0064239483,
-0.006000652,
0.0038875556,
0.012671806,
-0.03459518,
-0.0016339247,
-0.05889579,
0.011317257,
-0.008432067,
-0.0069048135,
0.00027196802,
-0.018868867,
0.010321663,
0.0056247646,
-0.025831249,
-0.0049136262,
-0.012407669,
0.0035793956,
-0.026806524,
-0.026833614,
-0.010172662,
-0.02312215,
0.024110971,
-0.00394851,
0.015455403,
0.01811032,
0.00037758052,
-0.009149978,
-0.009061933,
0.007951203,
-0.035353728,
0.0058347196,
-0.014358219,
0.018746957,
-0.0010438493,
0.0061428794,
0.00436842,
-0.017460136,
-0.009766298,
0.020724598,
-0.0065153805,
-0.0120080765,
-0.007754793,
0.015482495,
0.027199343,
0.009691798,
-0.018042592,
-0.0210226,
0.012874988,
-0.015943041,
0.016213952,
0.02243133,
-0.046596482,
0.0015712768,
0.01465622,
-0.01549604,
0.027822435,
0.010220072,
0.018381229,
-0.024544427,
-0.0059904926,
-0.008188249,
-0.022959605,
-0.012942716,
-0.003772419,
-0.005147286,
0.023745243,
0.012109668,
0.02879771,
-0.008249203,
-0.011777803,
-0.007856384,
-0.009840799,
-0.008201794,
0.020589145,
-0.029854259,
-0.037033368,
-0.0052895136,
0.0106061185,
0.0050050584,
0.0075787012,
0.0044666254,
-0.01265826,
0.020941326,
-0.017229863,
0.017758137,
0.01628168,
-0.012949488,
-0.0049508763,
0.00782252,
0.025343612,
0.0013164523,
-0.012400895,
-0.0061428794,
0.0009083944,
0.0041313744,
-0.01265826,
0.026955524,
-0.012509259,
0.0053030592,
-0.010626436,
0.018394776,
0.002472052,
-0.021903057,
-0.013735127,
0.033592813,
0.0005528253,
0.0014849243,
-0.02630534,
-0.021279965,
-0.009671479,
0.03134426,
-0.0073958375,
-0.03733137,
-0.012665032,
-0.018516684,
0.0009574968,
0.0056721736,
0.021307055,
0.00070944504,
0.0027802116,
0.013410035,
-0.0026515296,
-0.01660677,
-0.012184168,
0.04131374,
0.0019166868,
0.012177395,
-0.019546142,
-0.01643068,
0.023921335,
-0.009590207,
0.039471556,
-0.023406606,
0.013735127,
-0.031886082,
0.027375434,
-0.010951528,
-0.022959605,
-0.014290491,
-0.0046393303,
0.0076057925,
0.014791675,
0.016254587,
-0.018001955,
0.08121876,
0.01949196,
-0.008120521,
0.0047612395,
-0.030016804,
0.01798841,
-0.0040805787,
0.008885841,
-0.009806935,
-0.0312359,
0.01423631,
-0.017934227,
0.017893592,
-0.015753405,
-0.010646755,
0.028282981,
-0.006054834,
0.01238735,
-0.015685678,
0.011608484,
0.012902079,
-0.011771031,
0.013274579,
0.014493674,
-0.054398686,
-0.013897672,
0.01951905,
0.022336513,
-0.015306403,
-0.007483883,
0.009596979,
-0.015807586,
-0.051879223,
-0.018584412,
0.014602038,
0.007456792,
-0.0028716438,
-0.008831659,
0.018787595,
0.0125228055,
0.007483883,
0.015509586,
-0.010335209,
0.003664055,
0.017107954,
-0.019288776,
0.0040873513,
0.010037208,
-0.022228148
] |
Apolipoprotein E is immunochemically localized to the senile plaques, vascular amyloid, and neurofibrillary tangles of Alzheimer disease. In vitro, apolipoprotein E in cerebrospinal fluid binds to synthetic beta A4 peptide (the primary constituent of the senile plaque) with high avidity. Amino acids 12-28 of the beta A4 peptide are required. The gene for apolipoprotein E is located on chromosome 19q13.2, within the region previously associated with linkage of late-onset familial Alzheimer disease. Analysis of apolipoprotein E alleles in | [
-0.019353997,
0.0003359625,
-0.009344632,
-0.035128657,
-0.033722486,
0.022396436,
0.0029721297,
0.018126795,
-0.030577783,
0.004045931,
0.00739517,
-0.014854257,
-0.0065706437,
0.011690376,
-0.028941512,
-0.005768488,
0.018561428,
0.010776367,
-0.00038469906,
0.026384842,
-0.023406321,
0.033978153,
0.026589375,
-0.018663697,
0.021399334,
0.0013925866,
0.0057077673,
-0.054559354,
-0.015148274,
-0.03137035,
0.005637459,
-0.005474471,
-0.032444153,
-0.011287701,
0.014777557,
-0.0026030103,
-0.007062803,
-0.0031223341,
0.016132591,
-0.006717652,
0.0073056864,
0.028660279,
-0.0052955044,
-0.0055192127,
0.022345303,
0.0013078968,
-0.007900112,
-0.0020197697,
-0.028941512,
0.030219847,
-0.0008980306,
0.021706134,
-0.010143591,
-0.026538242,
-0.009587515,
-0.022102417,
-0.007235378,
0.010680492,
-0.0017896695,
-0.012284802,
0.014330139,
-0.015071574,
-0.008826906,
0.0022259015,
-0.008290005,
0.01631156,
0.012374287,
0.030859016,
-0.0014373283,
0.0016937944,
0.037250694,
0.0010706058,
-0.034642886,
-0.007733929,
0.03408042,
-0.0070564114,
-0.005953847,
0.006008176,
-0.012412637,
0.013933855,
0.026461542,
-0.037685327,
-0.011875736,
0.020491716,
0.033492386,
0.0064779646,
-0.013882722,
0.0130645875,
0.01479034,
0.0088908225,
0.014189523,
0.0037519142,
0.003838202,
0.0029705318,
-0.016183725,
-0.0015188222,
0.017487628,
0.017513195,
-0.014419623,
0.00025147252,
-0.007912896,
0.017615462,
-0.026435975,
-0.00565983,
-0.01143471,
0.0061807516,
-0.014138389,
0.0067560025,
0.012208102,
-0.0076508373,
-0.0024096621,
0.032162916,
0.014879824,
-0.03858016,
0.008040729,
-0.0009116129,
0.0088524725,
-0.022281386,
-0.017832778,
0.0076827956,
0.005135712,
0.03160045,
0.019200597,
-0.003911706,
-0.002906615,
0.016452176,
0.0064619854,
-0.012450987,
-0.010929767,
-0.002133222,
0.021220367,
0.0059602386,
0.011262135,
-0.00371676,
-0.0436168,
-0.026998444,
-0.023917655,
-0.00039628395,
-0.012252844,
-0.03477072,
0.01867648,
0.024467338,
-0.012719437,
-0.00743352,
0.0065706437,
0.047426242,
0.033441253,
0.028788112,
0.02161665,
0.016068675,
-0.003796656,
0.0074846535,
0.0027564105,
0.005496842,
0.00846258,
0.004247269,
-0.002153995,
0.023508588,
-0.03377362,
-0.011773469,
-0.013384171,
-0.0067304354,
-0.019584097,
0.008673505,
0.013013454,
0.019034414,
-0.014611373,
-0.020824082,
0.017359793,
-0.020248832,
-0.03556329,
0.008711856,
-0.019929249,
0.023879305,
-0.0036400598,
-0.005397771,
0.037685327,
0.018510295,
-0.03213735,
-0.036304723,
0.00017357398,
0.018075662,
0.013601488,
-0.0076188785,
0.006998886,
0.01627321,
0.041954964,
-0.010201116,
0.007535787,
-0.02492754,
0.0020245637,
-0.010079674,
0.0035090304,
-0.050187446,
-0.6369178,
-0.033492386,
0.012367895,
-0.0021124491,
0.004729841,
0.034489486,
0.017474845,
0.0005185248,
-0.015659608,
0.024518471,
-0.011217393,
0.02225582,
-0.018395245,
0.0049535497,
-0.022268603,
-0.020542849,
0.0073440364,
-0.028685845,
0.036432557,
-0.008142997,
-0.03213735,
0.0019270906,
-0.011306876,
0.015608475,
0.010341733,
0.009855965,
0.01859978,
-0.033211153,
-0.020210482,
0.026998444,
-0.006564252,
0.036688223,
-0.02256262,
0.023585288,
0.043054335,
0.0008844483,
0.0014900597,
0.011421926,
0.017960612,
0.024237238,
0.010974509,
-0.006915794,
-0.011006467,
-0.014253439,
-0.0019398739,
0.027995544,
0.007516612,
0.0054233377,
-0.0018040508,
-0.0077467123,
0.01665671,
0.0009435713,
-0.040855598,
-0.0070755864,
-0.014432406,
0.017436495,
0.020466149,
-0.02248592,
0.017474845,
0.01116626,
0.018996064,
0.0038797478,
-0.011907694,
-0.01723196,
-0.024262805,
0.0027995545,
-0.040625498,
0.002984913,
0.014585806,
-0.006839094,
0.020159349,
0.03091015,
-0.0048321076,
-0.018586997,
0.030628916,
-0.0087949475,
0.015940841,
0.017142477,
-0.020005949,
0.004355928,
-0.009235973,
0.009319065,
-0.01696351,
0.014266223,
-0.008040729,
0.015378375,
-0.020887999,
0.024492905,
-0.00017037813,
-0.0034674846,
0.038247794,
0.0014373283,
0.0052539585,
-0.047963142,
-0.018190712,
0.011332443,
0.011428318,
0.011952436,
0.005969826,
-0.016081458,
-0.015224974,
0.0014293387,
-0.0093510235,
0.0024176517,
0.033952586,
0.016222076,
-0.015915275,
0.0023808996,
0.049803946,
-0.009242364,
-0.0066473437,
0.007695579,
-0.003438722,
-0.018817097,
-0.020236049,
-0.01727031,
0.0048864367,
0.01623486,
0.005771684,
-0.037327394,
0.02248592,
0.004093869,
0.010622967,
0.002235489,
0.017756078,
0.019238947,
0.009670607,
-0.015595691,
-0.011364401,
-0.00949164,
0.0221152,
-0.011767077,
-0.0005476868,
0.0004490153,
0.017334227,
0.007414345,
0.014854257,
0.005285917,
-0.0087182475,
-0.04379577,
-0.0062766266,
0.009235973,
0.015876925,
0.0023777038,
-0.016055891,
-0.006487552,
-0.007011669,
-0.0060177636,
-0.022166334,
0.0040683025,
-0.0038861395,
0.013601488,
-0.022243036,
0.027612044,
0.023406321,
-0.00034535027,
-0.024147755,
-0.0013758084,
-0.01634991,
0.0005392977,
0.0027148647,
0.011313268,
0.0020309554,
0.023086736,
-0.010661317,
-0.02462074,
0.0072673364,
0.017653812,
-0.021297067,
-0.040037464,
0.002494352,
-0.0020117802,
-0.026972875,
0.0017736903,
-0.0047330367,
0.025809592,
-0.0046339654,
-0.006545077,
0.0129495375,
-0.017474845,
-0.011875736,
-0.009964624,
0.003991602,
0.00827083,
0.048806842,
0.0046627284,
0.034591753,
0.028890379,
0.004074694,
0.008641547,
0.020951916,
0.048806842,
-0.010392866,
0.010130808,
-0.0042440733,
-0.022818286,
0.009670607,
0.0061392053,
0.009926274,
0.012802528,
0.0210414,
-0.024671873,
0.015276107,
-0.01882988,
0.019532964,
-0.039935198,
0.0068902276,
-0.0095427735,
0.022958903,
0.010111633,
-0.012041919,
0.0008317169,
0.0019989968,
-0.00857763,
-0.025259906,
0.004563657,
0.021910667,
-0.0038062434,
0.011856561,
-0.017462062,
0.011645635,
0.012917579,
-0.0013622261,
0.0048289117,
-0.0067751775,
0.026410408,
0.029989747,
0.022012934,
-0.010763584,
-0.036355857,
-0.020977482,
-0.016899593,
0.012674695,
0.04722171,
0.004825716,
0.011063992,
-0.004208919,
0.0022083244,
0.018523078,
0.0005149295,
0.0016067077,
0.026487108,
0.019302864,
0.01902163,
-0.011658418,
-0.0088908225,
0.014739207,
0.034284953,
0.00008429024,
0.019929249,
-0.011735119,
-0.0133330375,
-0.009440507,
0.009127314,
-0.02306117,
0.0096769985,
0.011683985,
0.0028027503,
0.024083838,
0.027305244,
0.04550874,
-0.012137794,
-0.025809592,
0.004864066,
0.00051133416,
-0.019302864,
0.0018471946,
-0.018318545,
-0.0047713867,
-0.004026756,
-0.019507397,
0.012335937,
-0.013032629,
-0.030961283,
-0.0007889726,
0.005832405,
0.0053466377,
0.013051804,
0.030654483,
0.00046699189,
-0.042977635,
-0.04113683,
0.020530066,
0.042210635,
-0.015979191,
-0.0021507991,
-0.0058164257,
-0.013601488,
0.00023569308,
0.010667709,
-0.014854257,
0.013857155,
-0.0074079535,
0.0057812715,
-0.030398814,
-0.0027995545,
0.03850346,
0.0016154964,
0.017615462,
-0.022703236,
0.00048576744,
0.015557341,
-0.029401714,
0.00008653731,
0.030092014,
0.026435975,
0.010968117,
0.032009516,
-0.0018024528,
-0.012521295,
0.0047937576,
-0.017832778,
0.014163956,
0.0070755864,
-0.008136605,
0.009319065,
-0.017756078,
0.009088964,
0.01863813,
-0.010853067,
0.002037347,
-0.031472616,
-0.0000386247,
0.015186624,
0.0055863257,
0.014138389,
0.0045380904,
0.013908288,
0.019008847,
0.018088445,
-0.013703755,
-0.0006032145,
0.013921072,
0.032802086,
-0.017692162,
-0.017513195,
0.011946044,
-0.012035527,
0.022779936,
0.0132946875,
0.007957637,
-0.033569086,
0.02325292,
0.004074694,
0.011121518,
-0.004272836,
-0.0040171687,
0.02161665,
0.016285993,
0.001423746,
-0.00008174355,
0.025247123,
0.0098495735,
-0.0218084,
-0.0015411931,
0.0043495363,
0.0065578604,
0.020721816,
0.0022402827,
-0.0075997035,
0.0024384246,
0.019507397,
0.007817021,
0.0035441848,
0.0093318485,
0.012316762,
0.0023393538,
0.011837386,
0.010405649,
-0.005557563,
0.018011745,
0.016643927,
0.0069477526,
-0.013690972,
0.0072673364,
0.0046850992,
0.014419623,
-0.013039021,
0.00474582,
-0.0035633598,
0.023457455,
-0.008213305,
-0.00018236252,
-0.014163956,
-0.0048353034,
-0.018305762,
-0.012591603,
-0.009459682,
0.010456783,
-0.011294093,
0.0015411931,
0.0060369386,
0.009210406,
-0.023406321,
0.017295877,
-0.012821703,
-0.031012416,
-0.013205204,
0.009255148,
0.0094852485,
0.010380083,
-0.031804983,
0.005065404,
0.022319736,
-0.017525978,
-0.013716538,
0.0036400598,
-0.014803124,
-0.009939058,
0.010642142,
0.018727614,
-0.016362693,
0.0017305465,
-0.011300485,
0.0107508,
-0.011185435,
0.036892757,
0.009472465,
-0.0029753256,
-0.0045029363,
0.025298256,
0.038707994,
0.009779265,
-0.015800225,
0.008724639,
-0.033799186,
0.0077019706,
-0.036355857,
-0.00047178564,
-0.003719956,
0.006107247,
-0.011338835,
0.0042248983,
-0.008935564,
-0.0093318485,
-0.0014325345,
0.01905998,
0.0045412863,
-0.002607804,
0.016797327,
0.016937943,
0.017538762,
0.014163956,
-0.005234783,
0.018970497,
-0.014227873,
0.02279272,
-0.020057082,
-0.020542849,
0.01738536,
0.0109042,
-0.002037347,
0.0028554816,
0.005893126,
0.0043143816,
0.026742775,
-0.0098303985,
-0.028660279,
-0.028711412,
-0.0061008553,
-0.015046007,
-0.010993684,
0.01475199,
0.013307471,
0.011134301,
0.004058715,
-0.023700338,
-0.006749611,
0.017679378,
-0.030935716,
-0.0087949475,
0.00952999,
-0.0026030103,
0.020146566,
0.004988704,
-0.002077295,
-0.0020629137,
-0.0092934985,
-0.02702401,
-0.0043846904,
0.0038413978,
-0.0097920485,
0.034029286,
0.015391158,
0.03540989,
0.01288562,
0.017832778,
0.02283107,
-0.0014117616,
0.0014133595,
-0.015621258,
0.008066296,
-0.0036624307,
0.017717728,
0.011920477,
0.0015507806,
0.03479629,
-0.037787594,
0.007292903,
0.03019428,
0.004506132,
-0.021910667,
0.0093126735,
-0.052156083,
-0.041545898,
0.016145375,
-0.017436495,
0.008417838,
-0.03011758,
-0.005282721,
0.005321071,
0.032648686,
0.012687478,
-0.014675289,
0.038529027,
-0.021054184,
0.026487108,
0.01917503,
-0.0064811604,
-0.0047426242,
-0.02286942,
0.0036336682,
-0.0033907846,
0.027918844,
-0.0012919176,
-0.012419028,
0.012227277,
-0.0044454113,
-0.017295877,
0.011946044,
-0.02473579,
-0.0007889726,
-0.018586997,
-0.008245263,
-0.010412041,
-0.034924123,
-0.0067112604,
-0.036125757,
-0.006407656,
0.027305244,
-0.006998886,
0.019200597,
-0.023380753,
-0.028634712,
0.014675289,
0.01498209,
0.012431812,
-0.023981571,
0.010616575,
0.024250021,
-0.008769381,
-0.035128657,
-0.0017273506,
0.010584617,
0.022703236,
0.008980306,
0.018471945,
-0.01890658,
-0.009229581,
-0.013639838,
0.013703755,
-0.01944348,
-0.031242516,
0.036918323,
0.002214716,
0.0047330367,
-0.001995801,
-0.0024272392,
-0.020632332,
0.031089116,
-0.018267412,
-0.024786923,
0.008200522,
-0.024058271,
-0.014534673,
0.025515573,
0.01078915,
0.017692162,
0.0031798591,
-0.029785214,
-0.00379346,
-0.03129365,
0.013032629,
0.00815578,
0.022268603,
0.016797327,
-0.0109809,
-0.011389968,
-0.0069669276,
-0.0024240434,
0.005976218,
-0.018612564,
0.00052092166,
0.03461732,
-0.018702047,
0.0015763473,
0.018152362,
-0.0010154777,
-0.0096386485,
-0.008098255,
0.00375511,
-0.018114012,
-0.009018656,
-0.021667784,
0.020018732,
0.01631156,
-0.009708957,
0.003700781,
-0.024556821,
0.022358086,
-0.04852561,
-0.017206393,
0.026896175,
-0.04190383,
-0.0012232071,
0.002706875,
0.023559721,
0.023751471,
0.032341883,
0.010463174,
-0.016247643,
0.004710666,
-0.035512157,
0.009990191,
-0.0031558904,
0.028609145,
-0.019315647,
-0.0072225947,
-0.02329127,
0.0010170756,
-0.0077467123,
-0.021335417,
-0.026410408,
0.0055000377,
-0.011536976,
0.026819475,
0.025528356,
-0.028327912,
0.019302864,
-0.018497512,
0.016439393,
0.013997772,
-0.019008847,
0.013243554,
-0.030628916,
0.014279006,
-0.00081014505,
-0.0075613535,
-0.019814199,
0.016797327,
-0.021182017,
0.0041673733,
-0.0028954295,
-0.011818211,
-0.0046595326,
-0.0009763286,
-0.0109042,
-0.014649723,
-0.00028063456,
-0.020005949,
-0.010341733,
0.0027612043,
-0.0133330375,
-0.017743295,
-0.024901973,
0.043591235,
0.0009715349,
0.010137199,
0.01475199,
0.00041186367,
0.008200522,
-0.03175385,
-0.032802086,
0.0071714614,
-0.013422521,
0.033722486,
0.017756078,
-0.021360984,
0.0028379045,
-0.007772279,
-0.03175385,
0.0012240061,
-0.031089116,
0.004212115,
-0.0134864375,
0.012080269,
-0.0014860649,
0.013754888,
0.01917503,
0.01513549,
-0.02550279,
-0.003700781,
0.0063948724,
-0.046633672,
-0.008999481,
0.021949017,
-0.021591084,
-0.011543368,
0.02950398,
0.015634041,
-0.029248312,
0.03479629,
-0.01967358,
0.0026573397,
-0.02317622,
0.012604387,
-0.0006159978,
-0.01673341,
0.017257527,
-0.013627055,
0.010693275,
-0.020044299,
-0.0016490526,
-0.013742105,
-0.018612564,
0.00086527324,
0.008104647,
0.010923375,
-0.030373247,
-0.024313938,
0.0047713867,
-0.019839766,
0.015455075,
0.02809781,
-0.02267767,
0.00047138616,
0.009536382,
0.0041993316,
-0.024569605,
-0.022383653,
-0.022958903,
-0.0074271285,
-0.00116728,
0.006196731,
-0.003518618,
-0.00565983,
-0.0049151992,
-0.035154223,
0.004691491,
0.005493646,
-0.031549316,
-0.01658001,
0.010328949,
0.027228544,
-0.011038425,
0.001484467,
-0.011217393,
-0.020389449,
-0.024544038,
-0.0014916576,
-0.008021554,
0.0020645116,
-0.008187738,
0.0020309554,
-0.013857155,
-0.016937943,
0.0011576924,
-0.018765964,
-0.0211948,
0.004157786,
0.18029642,
-0.014521889,
-0.0076827956,
0.0007749908,
-0.0035761432,
0.0052539585,
0.003023263,
0.009050614,
-0.015915275,
0.015723525,
0.00533705,
0.0029753256,
-0.031421483,
0.0076827956,
-0.009855965,
-0.017909478,
-0.03850346,
-0.0098687485,
-0.0023904871,
-0.0014173543,
0.008993089,
-0.008066296,
0.006407656,
-0.007976812,
0.02237087,
0.005135712,
-0.020760166,
-0.0131029375,
0.003441918,
0.022025717,
-0.016976293,
-0.0044933488,
-0.0076636206,
0.0071714614,
-0.0051484955,
-0.005595913,
-0.019085547,
0.0016826089,
0.016081458,
0.012872837,
0.004371907,
0.012725828,
-0.019686364,
-0.016912377,
-0.011613676,
0.0211181,
-0.0024719809,
-0.018650914,
-0.035000823,
0.0048896326,
-0.04619904,
0.006807136,
-0.01120461,
0.011530585,
0.011485843,
0.004355928,
0.0023249725,
0.042133935,
0.001283928,
0.026896175,
-0.00739517,
0.002866667,
-0.034515053,
0.022051284,
-0.005142104,
0.02981078,
-0.0014860649,
-0.040548798,
0.024032705,
-0.016874027,
0.02965738,
-0.0057461173,
-0.0055703465,
-0.0032853219,
0.0005540785,
-0.012962321,
0.029989747,
0.01677176,
0.010680492,
0.0062958016,
-0.015825791,
0.014521889,
-0.03679049,
0.015876925,
-0.021284284,
-0.03027098,
0.030552214,
-0.0014141585,
-0.015518991,
-0.011536976,
-0.004215311,
-0.023316836,
-0.008059904,
0.011933261,
0.018881014,
-0.002152397,
-0.005730138,
0.008622372,
-0.017065777,
-0.01505879,
0.00023888893,
0.07056411,
0.011063992,
0.0071522864,
0.0013981793,
0.0037615017,
-0.007906504,
0.021603867,
0.009804832,
-0.000563666,
-0.016631143,
-0.034898557,
-0.007382387,
-0.010028541,
-0.0061487933,
0.039065927,
0.006877444,
-0.025221556,
0.038068827,
-0.0012903197,
-0.0089099975,
-0.041469198,
0.002588629,
0.028148944,
-0.0019494614,
0.008724639,
-0.033057753,
0.0026749168,
-0.028583579,
-0.02313787,
0.000004253836,
0.012163361,
-0.008596805,
0.024684656,
-0.008040729,
0.00032537628,
-0.013243554,
-0.004097065,
0.002590227,
0.036202457,
0.004947158,
-0.028941512,
0.03446392,
-0.008379488,
-0.0008540878,
0.017768862,
0.0045988113,
0.0065514687,
-0.008366705,
-0.00952999,
-0.016528876,
-0.02965738,
-0.00080654974,
-0.0024288371,
0.0074654785,
-0.02329127,
-0.0131029375,
-0.032955486,
-0.02538774,
-0.010482349,
-0.022434786,
0.016260426,
0.015352808,
-0.018292978,
-0.0087182475,
0.010853067,
-0.15830906,
-0.0026381647,
-0.0064939437,
-0.026257008,
0.0013622261,
0.018586997,
-0.0071842447,
-0.006787961,
0.0022402827,
0.0011640842,
0.01288562,
-0.01646496,
-0.011402751,
-0.007983204,
0.022779936,
-0.026333708,
-0.00632776,
0.014764774,
0.0016474547,
0.012240061,
-0.0037870684,
-0.034975257,
0.024326721,
-0.01619651,
0.036074623,
0.012316762,
0.0046819034,
0.0016634339,
0.0068518776,
0.007970421,
-0.0066665187,
-0.004950354,
0.060132895,
0.020172132,
0.014330139,
-0.002336158,
-0.018177928,
-0.033492386,
-0.0061136386,
0.017168043,
0.024492905,
0.045329772,
0.013984988,
-0.002746823,
-0.0047809742,
0.022243036,
0.019788632,
-0.03269982,
0.019686364,
0.0062031224,
0.006423635,
-0.01261717,
0.009478857,
0.042543,
0.012393462,
0.007861762,
-0.004170569,
0.03011758,
0.0073184697,
0.0011305278,
-0.0432333,
-0.010066891,
0.027049577,
-0.020772949,
0.013205204,
-0.035537723,
-0.020146566,
0.0048321076,
-0.020427799,
0.0027004834,
-0.0017065777,
-0.023994355,
0.018612564,
-0.019699147,
0.023163436,
0.020606766,
-0.01905998,
0.016950727,
0.0054521,
-0.01936678,
-0.020811299,
0.016758977,
-0.02958068,
-0.026384842,
-0.023879305,
-0.0066920854,
-0.0038893353,
0.003422743,
0.008353922,
-0.02313787,
-0.009076181,
-0.029197179,
0.012067486,
-0.014163956,
0.020236049,
0.032265183,
-0.0096002985,
0.011044817,
-0.003480268,
0.027995544,
0.029478414,
-0.0011776665,
-0.02263932,
0.0098687485,
0.04044653,
-0.007177853,
-0.015595691,
0.0090442225,
0.045534305,
-0.010041324,
-0.0020117802,
-0.00482252,
-0.0090058725,
0.02504259,
-0.01727031,
0.022933336,
0.00041266263,
-0.015403941,
0.019111114,
-0.025132073,
0.057422824,
-0.00857763,
0.02298447,
0.02988748,
-0.004208919,
-0.0014109627,
-0.10809604,
0.0019846156,
-0.016937943,
0.031012416,
0.008532888,
0.0018519884,
-0.0040427353,
0.050213013,
-0.01681011,
0.019085547,
-0.007868154,
-0.0040395395,
0.0054265335,
-0.025643406,
0.01101925,
0.013019846,
0.0005317076,
0.017168043,
-0.06038856,
0.031728283,
0.0031287258,
-0.0019862135,
0.012706653,
0.0043623196,
0.013639838,
-0.011645635,
-0.013857155,
0.009900708,
0.008711856,
0.018165145,
-0.004806541,
-0.027049577,
0.015851358,
0.0061807516,
-0.0077658873,
-0.018331328,
0.01684846,
-0.0060976595,
0.038938094,
0.002988109,
-0.007733929,
-0.017091343,
0.0072417697,
-0.0044230404,
-0.0059634345,
-0.0021492012,
-0.029759647,
0.0004685898,
-0.0048001492,
-0.0024655892,
0.0029641401,
-0.0017976591,
-0.018996064,
-0.002294612,
0.01631156,
0.012719437,
0.01642661,
-0.0010546267,
-0.016592793,
-0.020005949,
-0.0016346714,
-0.0023441475,
-0.03068005,
-0.025873508,
0.023994355,
-0.012585212,
-0.029836347,
-0.037173994,
0.005672613,
-0.013243554,
-0.0040171687,
0.0021507991,
-0.0037838726,
-0.0031159425,
-0.028302345,
0.0036656265,
0.00035873285,
-0.01963523,
0.02267767,
-0.007312078,
-0.017525978,
-0.014585806,
0.008443405,
-0.006762394,
0.0011696769,
0.023649205,
0.017398145,
0.0042824233,
0.00964504,
-0.033671353,
-0.0059282803,
0.033748053,
0.014125606,
-0.006308585,
-0.013601488,
0.0012775364,
-0.0025982165,
-0.024901973,
0.03610019,
0.0014013752,
-0.01859978,
-0.016362693,
-0.046250172,
0.009907099,
0.0037039767,
0.0131412875,
-0.0015931254,
-0.003400372,
0.018241845,
-0.016937943,
-0.015710741,
-0.00027863716,
-0.002392085,
0.010418433,
0.0009611484,
0.018050095,
-0.0034547013,
0.0044070613,
0.039321594,
-0.011198218,
0.02550279,
0.029120479,
0.0016714234,
0.03533319,
-0.0048512826,
0.014227873,
-0.029222745,
-0.014509106,
-0.010354516,
0.011728727,
-0.013959422,
0.028762545,
0.002532702,
-0.030705616,
-0.017960612,
0.02779101,
0.0048896326,
-0.016567226,
0.015148274,
0.0096578235,
0.0219618,
0.020082649,
-0.035742257,
-0.029273879,
0.004787366,
-0.018817097,
-0.009913491,
-0.006292606,
-0.02252427,
-0.024301155,
0.012866445,
-0.03144705,
0.02500424,
0.029299445,
0.006158381,
-0.018804314,
-0.02225582,
0.019788632,
0.0035857307,
0.0025566707,
0.002393683,
-0.015685175,
0.0066920854,
0.017129693,
-0.012438203,
0.021335417,
0.0023185806,
-0.0057013757,
-0.0022690452,
0.014291789,
0.005794055,
-0.026167525,
-0.0089291725,
0.008360313,
-0.0073248614,
0.003023263,
0.0022818286,
-0.013537572,
-0.019801416,
0.00047178564,
-0.0063533266,
0.0035633598,
0.0053658127,
0.0052763293,
-0.01094255,
0.03469402,
0.014739207,
0.0020357491,
0.0038254187,
0.028864812,
0.0002498746,
0.0038861395,
0.005381792,
0.022191903,
-0.0023904871,
0.030628916,
-0.0014269418,
-0.018663697,
-0.016822893,
-0.0008772576,
0.0061487933,
0.01254047,
-0.021859534,
-0.005810034,
-0.011070384,
-0.015800225,
-0.023419105,
0.0218084,
-0.038759127,
-0.03671379,
-0.012879228,
0.0016458568,
0.030219847,
0.009689782,
0.00811743,
-0.003480268,
-0.01475199,
0.000043867876,
0.0036432557,
0.010233074,
-0.025093723,
0.008724639,
0.006717652,
0.01246377,
-0.0052251955,
0.008743814,
0.0134480875,
-0.0009275921,
0.023866521,
-0.0067304354,
0.018778747,
-0.033262286,
0.00045980126,
-0.03323672,
-0.02207685,
0.0132179875,
-0.016669493,
-0.0064555937,
0.0051900414,
0.026742775,
-0.0043846904,
0.07746712,
0.0048321076,
-0.01650331,
0.0037838726,
-0.013921072,
0.020031516,
-0.015046007,
0.008596805,
-0.017244743,
-0.020261616,
-0.0052507627,
-0.039653964,
0.03221405,
-0.03571669,
-0.026090825,
0.004352732,
-0.012029136,
0.02146325,
-0.0074079535,
-0.024224455,
0.0039596437,
-0.02469744,
0.017960612,
0.011856561,
-0.030296547,
0.03431052,
0.047784176,
-0.018292978,
0.008162172,
-0.036228023,
0.00048017473,
-0.009689782,
-0.036049057,
-0.008015162,
0.0046946867,
-0.023738688,
-0.0051900414,
-0.017922262,
0.005794055,
0.001283928,
-0.0007238574,
0.021092534,
-0.027842144,
-0.011402751,
0.027075144,
-0.015723525,
-0.018612564,
-0.019980382,
-0.020376666
] |
Sulfolobus islandicus is being used as a model for studying archaeal biology, geo-biology and evolution. However, no genetic system is available for this organism. To produce an S. islandicus mutant suitable for genetic analyses, we screened for colonies with a spontaneous pyrEF mutation. One mutant was obtained containing only 233 bp of the original pyrE sequence in the mutant allele and it was used as a host to delete the β-glycosidase (lacS) gene. Two unmarked gene deletion methods were employed, namely plasmid integration and segregation, and marker replacement and looping out, and | [
-0.016610978,
-0.0074007967,
-0.0024453918,
-0.016869463,
-0.043289218,
0.015441,
-0.01828432,
-0.0005343981,
-0.01840676,
-0.008230666,
0.006666159,
0.004669712,
0.014407066,
0.022175182,
-0.0008132884,
-0.007387192,
0.028025076,
-0.014012538,
-0.01738643,
0.021263685,
-0.005900911,
0.0060199494,
0.010910733,
-0.0032956672,
-0.00450986,
0.020869158,
-0.017468056,
-0.021209268,
-0.023018654,
0.02242006,
0.009570699,
-0.010012843,
-0.017889794,
-0.0064246804,
-0.032568946,
-0.027889032,
0.011182821,
0.0019471305,
0.01704632,
-0.0077000936,
0.0023144495,
0.019535925,
-0.0061117793,
-0.007087895,
-0.0025270183,
-0.00450986,
-0.0056560314,
-0.0039690854,
0.009951622,
0.008176248,
0.014271021,
0.02105962,
-0.01803944,
-0.0021477954,
-0.013026218,
-0.01179502,
0.01831153,
-0.003020178,
0.0017175562,
-0.02393015,
-0.00799939,
0.008890479,
-0.04258179,
0.021209268,
-0.02393015,
0.014475088,
0.016978297,
-0.01476078,
-0.0092646,
-0.00020374723,
0.021318104,
0.021726236,
-0.0033653898,
-0.019957663,
0.01957674,
-0.017345617,
-0.013910504,
-0.0038772556,
0.008747633,
0.010475392,
0.0037072005,
-0.026365338,
-0.014624735,
0.0014446178,
0.03319475,
0.016053198,
0.006070966,
0.01291058,
-0.018937333,
0.0010390364,
0.010291733,
0.0413846,
0.016570166,
0.0048873825,
-0.027807405,
0.029548768,
-0.024379095,
0.03610609,
0.008251072,
-0.038527675,
0.0040813214,
0.010312139,
-0.00074994285,
-0.018638035,
-0.019250233,
0.022147972,
0.00020980544,
-0.02733125,
0.0010279829,
-0.012624888,
-0.006244422,
0.04720729,
-0.004707124,
-0.027997866,
0.029766439,
-0.017032716,
0.029575977,
0.00016442199,
-0.023494808,
0.0047751465,
0.026338128,
0.0024862052,
0.015046473,
-0.021386126,
0.034827277,
-0.013019416,
-0.023739688,
-0.00016877966,
-0.007448412,
-0.019590344,
0.008652402,
0.0047819484,
0.008972106,
0.01695109,
0.019685574,
-0.009121754,
-0.024800831,
-0.02507292,
-0.0007809779,
-0.02303226,
0.008604786,
0.025127336,
-0.020624278,
0.0069042356,
-0.0067954003,
0.008053808,
0.012087515,
-0.005009822,
0.008829259,
0.006774994,
0.0124820415,
-0.016461331,
0.013162262,
-0.0044554425,
0.03950719,
0.019522322,
-0.017100738,
0.03063712,
-0.030283406,
-0.011033173,
-0.005264905,
-0.0070946976,
-0.006013147,
-0.0073735877,
-0.0024691995,
0.030582704,
0.020297773,
0.010475392,
-0.0029810653,
0.00787695,
-0.008414324,
0.0025678314,
-0.016134825,
0.012339195,
0.0063940706,
0.007897357,
-0.0148015935,
0.0039112666,
0.014026142,
-0.02473281,
-0.014148582,
0.021386126,
0.018923728,
0.03229686,
0.0032684584,
0.0025032107,
-0.003788827,
0.003054189,
0.0018604024,
-0.014162186,
-0.015835527,
0.0069858623,
0.020311378,
0.006581131,
-0.63864523,
-0.018787684,
0.009740754,
-0.0152505385,
-0.015699483,
0.011897053,
0.013624812,
-0.02278738,
-0.014148582,
0.024202237,
-0.0014497194,
0.016434122,
0.018896518,
-0.016080407,
-0.0020338586,
-0.020515444,
0.015631462,
-0.02696393,
0.031834308,
-0.019658366,
-0.04032346,
0.003560953,
0.009550293,
0.020256959,
0.030773165,
0.037901875,
0.021046015,
-0.023522018,
-0.00904693,
0.013706438,
-0.012318789,
0.02380771,
-0.024202237,
-0.02572593,
0.040105786,
-0.0042513767,
-0.0028331175,
0.016910275,
0.00901972,
0.023277137,
0.0004991116,
0.0045438716,
0.021195663,
-0.003999695,
-0.008543567,
0.028732505,
-0.010033249,
0.015917154,
0.014475088,
-0.010638645,
0.0015372979,
0.016379705,
-0.017155156,
0.008067412,
0.034446355,
0.0026834689,
0.017209573,
-0.025766743,
0.030936418,
0.009944821,
-0.008836062,
0.015509022,
-0.011373283,
-0.012978603,
-0.017685726,
0.0016155231,
-0.013971725,
0.00806061,
0.018474782,
-0.022678543,
0.016270868,
0.018923728,
-0.01405335,
0.014352648,
-0.007482423,
0.044976164,
0.0041425414,
0.010080865,
-0.013427548,
0.00799939,
0.016815046,
0.0074075987,
-0.016284473,
0.012488844,
0.013073834,
0.010176095,
-0.033221956,
0.014379856,
-0.023277137,
-0.017413639,
0.018706057,
0.02322272,
-0.014733571,
-0.016447727,
-0.018556409,
-0.001090053,
-0.029358307,
-0.007026675,
0.020093707,
-0.042228073,
-0.013760856,
-0.018216299,
0.016502144,
-0.013652021,
0.04304434,
0.0045540747,
-0.0047717453,
0.009659128,
0.03275941,
-0.026923118,
0.0024113809,
-0.005173075,
-0.0022634328,
0.0028331175,
0.0031086067,
-0.023372369,
0.015386582,
-0.0096455235,
-0.010570623,
-0.030365033,
0.016991902,
0.013257493,
-0.00460169,
-0.009155765,
-0.012264372,
0.031915937,
0.0033313788,
-0.026569404,
0.00074399094,
0.00024870553,
-0.005999543,
-0.01000604,
0.027290437,
-0.029167846,
0.008604786,
-0.0025253177,
0.030365033,
0.015849132,
-0.0047445362,
-0.016570166,
-0.031725474,
0.0030167769,
0.00040388078,
0.005305718,
-0.023141094,
-0.0172912,
-0.017127946,
-0.0065913345,
-0.0011682783,
0.003001472,
0.022624126,
0.015046473,
-0.0042139646,
0.025984414,
-0.006271631,
-0.00799939,
-0.040187415,
-0.031698264,
-0.0077409064,
0.010795096,
0.022692148,
-0.00092850067,
-0.0004283262,
-0.00050931494,
-0.020365795,
0.002785502,
-0.0071967305,
0.0035371454,
-0.0053091194,
-0.028868549,
0.007788522,
-0.019957663,
0.00015815122,
-0.007645676,
-0.0031137082,
0.018706057,
-0.026038831,
0.017903397,
-0.016515749,
-0.018474782,
-0.015794715,
0.0063668615,
0.0043228,
0.009523083,
-0.0044214316,
0.0021596993,
0.02207995,
0.005877103,
0.023970962,
0.025984414,
0.012441229,
0.0017031014,
0.0041221348,
0.010203304,
0.012924185,
-0.004567679,
0.039207898,
0.008441534,
-0.009448259,
0.038282797,
-0.00084729935,
-0.0044792504,
0.021699026,
-0.044540823,
0.023916544,
-0.03232407,
0.00540435,
-0.024215842,
0.012359602,
0.015767505,
0.015413791,
0.011706591,
-0.0020542652,
-0.006550521,
0.0042139646,
-0.00778172,
-0.0075708516,
-0.0045778826,
-0.0041051293,
0.003591563,
-0.011033173,
0.003992893,
0.029412724,
-0.010339348,
-0.027997866,
-0.00092594983,
-0.0059281196,
-0.0045744814,
0.002618848,
-0.015767505,
0.0012958196,
0.007414401,
-0.0044826516,
0.018665245,
0.022841796,
0.031290133,
0.015536231,
-0.01016249,
0.03754816,
0.009414248,
-0.009740754,
0.016298078,
0.013080636,
0.007774918,
0.02813391,
0.02837879,
0.035180993,
-0.004975811,
-0.018393155,
0.017658519,
-0.011223635,
0.013373131,
-0.012992207,
0.0039554806,
-0.0008587781,
0.0036289752,
0.00632945,
0.025222568,
0.020855553,
0.005431559,
-0.00042194914,
0.00026549847,
0.0059621306,
-0.026283711,
0.013379932,
0.012420822,
-0.003992893,
-0.033221956,
0.0067647905,
0.0102849305,
-0.030120153,
0.008502753,
-0.012604482,
-0.010053655,
0.009659128,
-0.01189025,
0.009577502,
0.019957663,
0.022066345,
-0.018352343,
-0.010727074,
-0.027372064,
0.028460417,
0.021753443,
0.016855858,
-0.02837879,
-0.026746262,
0.005475773,
-0.0014888321,
0.015740298,
0.008686413,
0.022460874,
0.013699636,
0.0036221729,
-0.025916392,
-0.010142084,
0.003292266,
-0.02733125,
0.017590497,
0.0062954384,
-0.012053503,
0.0063464553,
-0.00005893471,
-0.015930759,
0.06840295,
-0.0006861722,
-0.005812482,
0.0024198836,
0.003467423,
-0.015182517,
0.0027191804,
0.008257874,
-0.0007865047,
-0.0014811796,
-0.021086829,
0.008291885,
-0.017182363,
-0.0033738925,
0.030256197,
-0.0142302085,
-0.017454453,
-0.035806794,
-0.028460417,
-0.014910428,
0.019073376,
0.034691233,
0.016406912,
0.024882458,
0.022909818,
0.011366481,
-0.016651792,
-0.04005137,
0.02417503,
-0.03659585,
-0.012243965,
0.020950785,
0.008686413,
0.0042003603,
-0.00048380665,
0.011448107,
-0.00074186525,
-0.032188024,
0.0046901186,
0.021535773,
0.010026447,
-0.0063464553,
0.0025984414,
0.023045862,
0.023630852,
-0.0024385897,
0.009829183,
0.011087591,
-0.016012385,
-0.007564049,
-0.013468361,
-0.0009650625,
0.00018525374,
0.017400034,
0.013073834,
-0.006006345,
0.021345312,
0.008536764,
-0.0068940325,
0.01263169,
0.021018807,
0.01578111,
0.015957968,
0.0053329268,
-0.001460773,
-0.0009812177,
-0.021998324,
0.01803944,
-0.016352495,
-0.026882306,
0.03501774,
-0.0256307,
-0.019903244,
0.002096779,
0.030501077,
0.011196425,
0.005071042,
-0.01692388,
-0.010148887,
-0.0061866036,
-0.007836138,
-0.012155537,
0.017644914,
0.020297773,
-0.009767963,
0.0059485263,
0.023753291,
-0.003887459,
-0.041221347,
-0.009815578,
0.018828496,
-0.041983195,
-0.0018365948,
-0.0033347798,
0.026242899,
0.013890098,
0.005241097,
-0.020461027,
0.007251148,
0.007910961,
-0.007842939,
-0.010427777,
-0.0044690473,
-0.036242135,
0.013985328,
0.013114647,
0.031018045,
-0.021168455,
-0.036323763,
0.023630852,
0.0053873444,
0.00012233337,
-0.004788751,
0.00062707806,
0.0036119695,
0.020950785,
0.019889642,
0.019930454,
-0.013379932,
-0.017332012,
0.008815655,
-0.025562678,
-0.02952156,
-0.009380237,
-0.0120330965,
-0.009699941,
-0.018012233,
0.0006785197,
-0.028868549,
-0.0110127665,
0.00759806,
-0.006632148,
0.006339653,
0.017019112,
0.032596156,
0.023358764,
-0.004870377,
0.0023144495,
-0.0027889032,
-0.0011155612,
0.008550369,
-0.028542042,
0.01463834,
-0.0064859004,
-0.032188024,
0.010618239,
0.0027889032,
-0.04462245,
0.015141703,
0.0046459045,
-0.022093555,
0.024610369,
0.0071967305,
-0.012203151,
-0.0342831,
-0.0012983704,
-0.008135434,
0.014066955,
-0.010033249,
-0.021222873,
-0.010046854,
-0.002986167,
0.00938704,
-0.008142237,
-0.016842254,
-0.025671514,
-0.008421127,
0.01918221,
-0.005210487,
-0.003690195,
-0.01405335,
0.0070198732,
-0.0071355104,
-0.020583466,
-0.005815883,
-0.029630395,
-0.009618315,
-0.0010194802,
0.06399512,
0.035589125,
0.017576892,
-0.0049213935,
0.053601358,
0.023127489,
0.0150600765,
-0.0010424375,
0.00055012817,
-0.0016835452,
-0.031915937,
0.0020151525,
0.016107615,
0.004268382,
-0.014665549,
-0.012332394,
0.012570471,
0.040922053,
-0.02417503,
0.01803944,
-0.0071151042,
-0.030800374,
-0.032922663,
0.004904388,
0.0044112285,
-0.0032021368,
-0.030827582,
-0.024215842,
0.020461027,
0.002668164,
-0.001948831,
-0.0070198732,
0.013583999,
-0.019658366,
0.03803792,
-0.0045846845,
0.008074215,
-0.017236782,
-0.016842254,
0.0014879819,
0.004026904,
-0.0013902002,
0.015168912,
0.008829259,
-0.011053579,
0.0072783567,
-0.0005939173,
0.008475545,
0.0075028297,
-0.0012652098,
0.008972106,
-0.014189395,
-0.012645295,
-0.012774536,
-0.0026018426,
-0.04524825,
0.00660834,
0.0062920377,
-0.013502372,
0.014583923,
-0.011706591,
-0.026106853,
0.025657909,
0.015645066,
0.05194162,
0.013087438,
0.04250016,
0.03450077,
-0.0016265768,
-0.030011319,
0.007747709,
0.0072443457,
-0.0015492017,
0.011142008,
0.0012397014,
-0.00651651,
-0.018678848,
0.005407751,
-0.012862965,
-0.013611208,
-0.022773774,
0.025562678,
-0.017440848,
0.02127729,
-0.0142302085,
0.00509485,
-0.015522626,
0.03839163,
-0.0017906799,
-0.0020372598,
-0.006271631,
0.005870301,
-0.007223939,
0.0047241296,
0.014026142,
0.015005659,
0.003894261,
0.00032820628,
0.0051424652,
-0.026338128,
-0.029820856,
0.00654712,
-0.009271402,
0.037602577,
0.015182517,
0.0083395,
-0.024555951,
0.0017073529,
0.011155613,
-0.009169369,
-0.0216174,
0.03499053,
-0.016175639,
-0.006363461,
0.00018514745,
0.02127729,
0.00053779915,
0.0007031777,
-0.008638797,
-0.012101118,
-0.01093114,
-0.00047700448,
0.030854791,
0.016066803,
-0.0065947357,
-0.018760474,
-0.007679687,
-0.0060879714,
-0.007727302,
-0.019998476,
-0.006689966,
-0.0432348,
0.01463834,
-0.0140397465,
0.0048907837,
0.01309424,
-0.008414324,
0.0023807709,
-0.011692987,
0.04639102,
-0.019277442,
0.012495646,
0.018229904,
-0.0118766455,
-0.013393537,
0.012917383,
0.011060381,
-0.02402538,
0.0013136754,
-0.0247056,
-0.009380237,
-0.038282797,
-0.0020202543,
0.010788294,
0.015522626,
-0.011931064,
0.013332318,
-0.016134825,
0.020773927,
-0.000016301372,
-0.01253646,
0.01726399,
-0.010495799,
0.020229751,
0.009475469,
0.0009846188,
-0.014107768,
0.0028739306,
-0.01599878,
-0.007910961,
-0.012400416,
-0.0065607247,
-0.0047037234,
0.0038364423,
0.0007677986,
0.010033249,
-0.022841796,
-0.02071951,
-0.027059162,
0.007414401,
-0.0046901186,
-0.020773927,
-0.02816112,
-0.005812482,
-0.009543491,
-0.012366405,
-0.013325515,
0.0026817685,
0.008189852,
-0.0106658535,
-0.031643845,
0.001911419,
-0.014951241,
0.035126574,
-0.009332622,
-0.02356283,
-0.026256502,
0.0028790324,
-0.035997257,
-0.0067307795,
0.0007848041,
0.0014990354,
0.007958577,
0.017236782,
-0.013468361,
0.0022226197,
-0.008047006,
0.016175639,
0.006363461,
-0.022025533,
0.019876037,
0.0027089773,
0.0059383227,
0.006482499,
-0.043506887,
0.02239285,
0.021168455,
0.0074756206,
-0.023127489,
0.026950328,
-0.012590877,
0.025712326,
-0.011312063,
0.0083122915,
0.02905901,
0.0029504555,
0.015046473,
-0.006703571,
-0.014992055,
0.0070198732,
0.009597908,
-0.01787619,
-0.010305337,
-0.009285007,
-0.0047615417,
0.03545308,
-0.0077341045,
-0.032868244,
-0.0012303484,
-0.004696921,
0.0237805,
0.016542956,
0.0038534477,
0.008087819,
-0.0059825373,
-0.028487625,
-0.03316754,
-0.0055437954,
-0.0036833927,
0.016447727,
0.0108563155,
-0.0004104704,
0.0028467218,
-0.016937485,
0.008836062,
-0.00697906,
-0.0009097946,
-0.000056171313,
-0.015209725,
-0.031725474,
0.0015628061,
0.0185292,
-0.0032327469,
-0.02146775,
0.0112712495,
-0.011978679,
0.0073395767,
-0.0054247566,
0.024311073,
-0.004836366,
0.011352876,
-0.014910428,
-0.020297773,
-0.011039975,
0.00799939,
0.0017668721,
-0.023848522,
0.0021750042,
0.17272153,
-0.010815502,
0.02924947,
0.04919353,
-0.002982766,
-0.0030813979,
-0.005829488,
0.002331455,
-0.021535773,
0.023100281,
0.018923728,
-0.0017124545,
-0.007910961,
0.0035167388,
0.012706514,
-0.017127946,
-0.015930759,
-0.0036527829,
-0.021535773,
-0.0005271707,
0.026011623,
0.0059553282,
-0.020052893,
-0.011039975,
0.043098755,
-0.008271478,
-0.014094164,
-0.011726998,
0.0048465696,
0.01748166,
-0.023059467,
0.022937028,
0.02016173,
0.00095400895,
-0.014107768,
0.012230361,
-0.0025270183,
0.006047158,
0.017862584,
0.013924109,
-0.009985633,
0.008482346,
0.01726399,
-0.019603949,
-0.030065736,
-0.027821008,
0.0049179927,
0.006482499,
-0.010128479,
0.00892449,
-0.016039593,
-0.0037480136,
-0.0010611436,
-0.0025627299,
0.020393003,
-0.036487017,
0.044540823,
0.001559405,
0.011570547,
0.03499053,
-0.025127336,
0.038718138,
-0.040513918,
0.0072579505,
-0.0074348077,
0.027426481,
-0.028705295,
-0.00056840904,
0.008693215,
-0.020637883,
-0.0018689052,
-0.030555494,
-0.01580832,
0.013597603,
-0.02183507,
-0.014202999,
0.024719205,
0.021182058,
0.025331402,
0.008319094,
-0.010557018,
0.0052274927,
-0.037003983,
0.0020797735,
-0.0037344093,
-0.019876037,
0.023984566,
-0.0059825373,
-0.039289523,
-0.0044826516,
0.008108226,
0.012584075,
-0.0064859004,
-0.017359221,
0.0075708516,
-0.0026919716,
0.007754511,
0.023263533,
-0.0012482041,
-0.017862584,
-0.020651488,
0.047016826,
-0.009890403,
0.0031358155,
-0.013808471,
0.01349557,
0.0033977001,
0.00416975,
0.005237696,
-0.012930987,
0.009094545,
-0.03379334,
0.0021562981,
-0.004567679,
0.015441,
0.014379856,
0.009495875,
-0.023889337,
0.027671361,
-0.0024113809,
-0.013597603,
-0.013563592,
-0.012597679,
-0.00092169846,
-0.019944059,
-0.0067307795,
-0.04029625,
0.028215537,
-0.0034011013,
-0.026161272,
-0.00096336193,
0.008074215,
0.007387192,
0.007026675,
0.0033977001,
0.00028484224,
-0.005536993,
-0.027249623,
-0.024936875,
-0.0021869082,
0.005173075,
0.012903779,
-0.010176095,
-0.003554151,
-0.0031120076,
-0.0194543,
0.021875884,
0.021114036,
-0.009332622,
0.0015823625,
-0.0018484986,
-0.03909906,
-0.0031511204,
-0.015849132,
0.011400492,
-0.038201172,
-0.0053533334,
-0.046282187,
0.014121373,
-0.0032310463,
-0.031262923,
0.013230285,
0.0044724485,
-0.012386811,
-0.0114617115,
-0.0037140027,
-0.17304803,
-0.0040473104,
-0.0049213935,
-0.033657297,
0.0056560314,
0.006815807,
0.021046015,
-0.010155689,
-0.016420517,
0.0026052436,
0.035561915,
0.015359374,
-0.038337216,
-0.022773774,
-0.0075708516,
0.007087895,
-0.02597081,
0.03384776,
0.006138988,
-0.0006241021,
0.023086676,
-0.027494503,
-0.012971801,
0.0010764486,
0.014747175,
0.013903703,
0.008040204,
0.010448183,
-0.0027769993,
-0.02016173,
-0.01417579,
0.02010731,
0.038745347,
-0.015536231,
-0.0017838776,
0.0022294219,
0.009012919,
0.0121895475,
-0.0024232848,
0.013475164,
0.021712631,
0.019876037,
-0.0028943373,
-0.016760627,
-0.028269954,
0.027889032,
0.022460874,
0.008965303,
0.027426481,
-0.0018195892,
0.00623762,
0.004295591,
0.0007070039,
0.016488539,
0.019631157,
0.0015441,
-0.0037174039,
0.0035439476,
0.002244727,
0.004064316,
-0.0063226474,
-0.037003983,
0.034908906,
-0.018937333,
-0.020066498,
-0.025140941,
-0.01408056,
-0.008734028,
-0.037656993,
0.006679763,
0.010427777,
0.027072767,
-0.005676438,
-0.0052036853,
0.01006726,
-0.0010449884,
-0.020569861,
0.028678086,
-0.006853219,
-0.0063906694,
-0.0068226093,
0.022488082,
-0.014475088,
0.0042819865,
0.023658061,
0.008455138,
0.002603543,
0.021440543,
-0.015985176,
0.004268382,
0.0132778995,
-0.025521865,
0.0010960049,
-0.015168912,
0.039969742,
0.028269954,
-0.0009506078,
0.015889946,
-0.0023229523,
0.0033994007,
0.015182517,
-0.01840676,
-0.013944516,
0.020773927,
0.04783309,
-0.011679382,
-0.02504571,
0.019359069,
0.062308177,
0.018148277,
-0.02791624,
-0.027521713,
-0.0005815883,
0.025154546,
-0.011924261,
0.009353029,
-0.0046527064,
-0.021780653,
0.019726388,
-0.016393308,
0.042037614,
0.009067336,
-0.0056526302,
0.0064042737,
-0.008591182,
-0.04263621,
-0.12374567,
-0.029712021,
-0.005883905,
0.016502144,
-0.006914439,
-0.0018774079,
0.0073259724,
0.034147058,
-0.020433817,
0.026610216,
0.005363537,
-0.022814589,
0.0061695976,
0.0045132614,
0.0016605877,
0.01670621,
-0.0072783567,
0.014924033,
-0.000063239226,
-0.0009965227,
0.00846194,
-0.009495875,
0.0001087821,
0.027181601,
0.0023858726,
0.000053965912,
-0.023875732,
0.022338433,
-0.0009803674,
0.025195358,
0.012726922,
-0.031099671,
0.015304956,
0.0029334498,
-0.00213079,
0.00072145864,
-0.009182974,
-0.015359374,
0.027426481,
-0.016978297,
-0.009591105,
-0.003406203,
0.0055199875,
-0.00024445416,
-0.0069994666,
0.004605091,
0.0020219549,
0.008577578,
-0.0027804004,
-0.024161424,
-0.030773165,
-0.020243356,
-0.02816112,
-0.00778172,
0.029848065,
-0.011325668,
0.02152217,
0.02322272,
-0.017658519,
-0.006737582,
0.008672808,
0.021209268,
-0.007978984,
-0.023889337,
-0.0068260105,
-0.009094545,
-0.009155765,
-0.04070438,
0.025834765,
-0.029766439,
-0.01062504,
0.018706057,
-0.01590355,
-0.0039146678,
-0.024011776,
-0.011414096,
-0.020406608,
0.00008832235,
0.010788294,
-0.02300505,
0.008210259,
-0.0032463511,
0.016162034,
-0.052485798,
0.016202847,
0.030038526,
0.021875884,
-0.005445163,
0.0068600215,
-0.009938018,
-0.010053655,
0.029140636,
0.0072579505,
-0.02146775,
-0.016434122,
0.022025533,
-0.033303585,
0.00042726335,
0.036214925,
0.0060437573,
-0.036269344,
-0.02816112,
-0.06127424,
0.01750887,
0.011985481,
-0.009155765,
0.004628899,
-0.006213812,
0.005560801,
0.0003109882,
-0.0077341045,
0.02001208,
-0.03616051,
0.0090401275,
-0.0037412115,
-0.0122235585,
-0.022705752,
-0.031779893,
0.03226965,
-0.0068974337,
0.033575673,
0.027821008,
0.0036697884,
0.0051424652,
0.010788294,
0.008040204,
-0.030827582,
-0.014379856,
-0.0042785853,
0.0030643924,
-0.016774232,
-0.041656688,
0.0034759257,
-0.022433665,
-0.0098359855,
0.011754206,
0.0075572473,
-0.02835158,
0.02587558,
0.010557018,
0.028433207,
0.04894865,
-0.028678086,
-0.027780196,
0.017427243,
-0.004591487,
-0.01000604,
0.009114952,
-0.019223025,
0.023685269,
0.021821465,
0.010461788,
0.02701835,
0.0062240153,
0.00051739253,
-0.015481813,
0.014407066,
-0.0045268657,
-0.010577425,
0.01612122,
-0.029222263,
-0.015345769,
0.030011319,
-0.004962207,
0.029439934,
-0.002797406,
-0.0142302085,
-0.014162186,
-0.011550141,
-0.003375593,
0.0055539985,
-0.052649047,
-0.037140027,
-0.0015219928,
0.02032498,
0.017427243,
0.013733647,
-0.013339119,
-0.023794105,
-0.015073681,
0.00395208,
0.023304347,
0.019032564,
-0.0213045,
-0.007931368,
0.012781339,
0.027467294,
-0.015168912,
0.021222873,
0.010992359,
0.002649458,
0.010672656,
0.0030967027,
0.03199756,
0.004020102,
0.0008396469,
0.0011844336,
0.036949564,
0.011577349,
-0.010829107,
0.011774613,
0.005792076,
-0.019440696,
-0.0015406989,
0.017372826,
-0.023617247,
-0.023018654,
0.007053884,
-0.007087895,
-0.04184715,
-0.004730932,
0.0031171094,
0.00429219,
-0.009169369,
0.0053227236,
0.01510089,
0.0075368406,
-0.005907713,
-0.034147058,
-0.0048057563,
-0.0025372216,
-0.017209573,
0.011965075,
0.0053227236,
0.01253646,
0.0027940047,
0.012325591,
-0.0046220967,
0.027861822,
-0.025113732,
0.0031154088,
-0.026732657,
0.0029419526,
-0.004792152,
-0.03226965,
-0.030963626,
0.00076567294,
-0.0011810324,
0.01578111,
0.0037003984,
-0.015495418,
0.08119109,
0.02205274,
-0.008455138,
-0.0074688187,
-0.028678086,
0.02587558,
0.022964235,
0.005843092,
0.008788446,
-0.053655773,
0.046853572,
-0.007944973,
0.015413791,
-0.029630395,
-0.037602577,
-0.0023059468,
0.0062648286,
0.022705752,
-0.01818909,
-0.007761313,
0.020855553,
-0.017318409,
0.011448107,
-0.00037837253,
-0.023467598,
0.012699712,
0.0185292,
-0.01828432,
0.011339271,
-0.042200867,
-0.0019250234,
-0.00092594983,
-0.019821618,
-0.0029963702,
-0.0000118042135,
-0.001309424,
-0.0021256884,
0.0019964464,
0.03526262,
0.014162186,
0.00382964,
-0.013407142,
-0.015345769,
-0.029358307,
-0.01580832,
-0.008713622,
-0.003992893,
-0.010121678,
-0.018134672
] |
ADAM13 is a member of the disintegrin and metalloprotease protein family that is expressed on cranial neural crest cells surface and is essential for their migration. ADAM13 is an active protease that can cleave fibronectin in vitro and remodel a fibronectin substrate in vivo. Using a recombinant secreted protein containing both disintegrin and cysteine-rich domains of ADAM13, we show that this "adhesive" region of the protein binds directly to fibronectin. Fibronectin fusion proteins corresponding to the various functional domains were used to define the second he | [
-0.04333551,
-0.001113887,
-0.014851826,
-0.006500989,
-0.022344042,
0.01920129,
-0.045191985,
0.010064764,
-0.017755888,
-0.009799553,
0.021031247,
-0.0072004837,
0.01184831,
0.0075319977,
-0.01853826,
-0.0055197077,
0.011225063,
0.012047218,
-0.04028558,
0.014652918,
-0.018763691,
0.013923587,
0.01448053,
-0.012856112,
-0.012869373,
0.018153705,
0.010475841,
-0.026003957,
0.011012894,
-0.021654492,
0.010363127,
0.0030432984,
-0.010084655,
0.018564783,
-0.0048434194,
0.016257446,
0.0054169386,
0.013870545,
0.009501191,
0.010018352,
0.015846368,
-0.022383824,
0.00759167,
0.00045956124,
-0.006656801,
-0.01042943,
-0.020023445,
-0.019758234,
-0.029305836,
0.011669292,
0.008175135,
0.019095205,
-0.001074934,
-0.017875234,
-0.025672443,
-0.01873717,
0.016748086,
0.015461812,
0.0068888604,
-0.0051318365,
-0.0021747318,
0.004047786,
-0.010058134,
0.016177882,
-0.0008743681,
0.018206747,
-0.008354153,
-0.00088431354,
0.0073927618,
-0.006325287,
0.060627278,
0.023192719,
-0.014666178,
-0.02206557,
0.03293923,
-0.002335516,
-0.0022476648,
-0.004697553,
-0.022847943,
0.0007637253,
0.00640485,
-0.00652751,
-0.016469615,
0.03346965,
0.0039450163,
0.0014014754,
-0.0005155042,
0.004548372,
0.0052810176,
0.0027731145,
0.017185684,
0.035273086,
-0.006331917,
0.013671637,
-0.03705,
0.00971999,
-0.018299572,
0.009070222,
0.005668889,
-0.0034643211,
-0.0034046485,
0.017132642,
-0.015010953,
-0.016986776,
-0.015249643,
-0.020049965,
0.0010177479,
-0.029199751,
0.018392395,
-0.0156209385,
0.013764461,
0.02821847,
0.012935676,
-0.05264442,
0.0033582365,
-0.013399795,
0.019811274,
0.0106813805,
-0.013618594,
-0.01727851,
0.010164219,
0.028085865,
0.0013194256,
-0.028032823,
0.018180227,
0.04341507,
0.00036549417,
-0.0034610059,
-0.010051504,
-0.011457123,
0.027926737,
-0.014215319,
0.02158819,
0.022291,
-0.01991736,
0.022688817,
-0.006895491,
-0.0095542325,
-0.022264479,
-0.027091322,
0.020726254,
0.0298893,
-0.012630682,
-0.0028228415,
-0.0049859704,
0.011589728,
0.036201328,
-0.008460237,
0.00089923164,
0.025009414,
-0.010323346,
-0.007306568,
-0.0024150794,
-0.003891974,
0.001580493,
0.0154352905,
-0.015594417,
0.020341698,
-0.002705154,
-0.017265247,
0.00020180913,
0.002821184,
0.0018863145,
-0.009852596,
0.021972746,
0.030154511,
-0.02207883,
-0.006421426,
-0.009912268,
-0.02703828,
-0.0030267227,
0.0010086313,
-0.015541376,
0.021163853,
0.0075784097,
-0.0035637752,
0.021177113,
0.011026155,
-0.028085865,
-0.026826112,
-0.00039305125,
-0.0065573463,
0.022118613,
0.0049196673,
-0.02063343,
0.009017181,
0.025871351,
-0.0086259935,
0.013253929,
-0.03349617,
-0.0026753177,
0.010058134,
0.0040776217,
-0.021521887,
-0.62420106,
-0.03705,
0.020063225,
0.00248967,
-0.012484817,
0.022582732,
0.014056193,
-0.018843254,
0.008698927,
-0.0013194256,
-0.024624858,
0.02563266,
-0.0123588415,
-0.018617826,
-0.0029852833,
0.0038356166,
-0.010383017,
-0.027767612,
0.010535514,
0.011775376,
-0.04741976,
-0.0058744275,
0.0011478672,
0.01635027,
-0.01067475,
0.0053738416,
0.024996154,
-0.018644346,
-0.0013898724,
0.010654859,
-0.019028902,
0.032329243,
-0.0050622183,
-0.0020321808,
0.053943954,
0.009136525,
-0.011138869,
0.03514048,
0.020116268,
0.023524232,
0.0005188194,
0.0031311496,
0.011351039,
-0.0014478873,
0.0011478672,
0.019983662,
-0.003164301,
0.019559324,
0.004143925,
-0.0016028701,
-0.0014818675,
-0.010323346,
-0.044316787,
-0.017742628,
0.0035140482,
0.0078834025,
0.026269168,
-0.024505513,
0.014493791,
0.0013285422,
0.022967288,
0.009845966,
-0.007286677,
-0.019081945,
0.00924261,
-0.0069220117,
-0.016482875,
0.028854977,
0.00043676965,
-0.00034808967,
0.01686743,
0.029730173,
0.021243416,
0.010853767,
0.019771494,
0.034954835,
0.009534342,
0.019758234,
-0.0043262574,
0.0041273492,
0.016443092,
0.012511337,
-0.0073397197,
-0.0062523535,
0.03174578,
0.020712994,
-0.029120188,
0.011762116,
0.008758599,
0.013976629,
-0.0026106725,
0.010581926,
-0.009308913,
-0.03705,
-0.011602989,
0.019280853,
-0.0026421663,
0.006239093,
-0.0031394374,
0.0016202746,
-0.012988717,
-0.010416169,
0.033893988,
-0.020341698,
0.022397084,
-0.001090681,
-0.03673175,
0.019108465,
0.047101505,
-0.030870581,
-0.0035438845,
0.007982857,
-0.004697553,
-0.029279314,
-0.022476647,
-0.024213782,
-0.011589728,
-0.005460035,
0.009753142,
-0.044741128,
0.006666746,
-0.023776183,
-0.013094802,
0.014016411,
0.039357338,
0.0069352724,
0.0029604197,
-0.035458736,
-0.0056589437,
-0.00038331305,
-0.0022261164,
-0.0150639955,
-0.0018200118,
-0.035246566,
0.017159164,
0.010522254,
0.010111176,
0.018418917,
-0.01779567,
-0.02156167,
-0.0055628046,
-0.018180227,
0.0055197077,
-0.010111176,
-0.031931426,
-0.022821423,
-0.021256676,
0.01092007,
0.015090516,
0.011762116,
-0.005022437,
0.0021913075,
0.01685417,
0.020567127,
0.01542203,
-0.011941133,
0.017212206,
-0.02866933,
0.011496904,
-0.006381644,
-0.007638082,
0.024465732,
-0.007180593,
-0.0127301365,
0.008201656,
-0.0063949046,
-0.016390052,
-0.0018912873,
0.0064380015,
-0.04171772,
-0.022834683,
0.02205231,
-0.025791787,
0.014613136,
0.0020669897,
0.03293923,
-0.010999634,
-0.021932965,
-0.015581157,
0.008964138,
0.012703615,
-0.008493388,
0.022436867,
-0.012199715,
0.027688047,
0.016893953,
0.019705191,
0.023855746,
-0.013399795,
0.021455584,
-0.008480128,
0.015541376,
-0.007306568,
0.011980915,
-0.0154352905,
-0.013724679,
0.027555441,
-0.0014802099,
-0.008950877,
0.029703652,
0.015382249,
-0.022039048,
0.008446977,
0.008334261,
0.021853402,
-0.009202828,
-0.007571779,
-0.007870141,
0.02630895,
-0.017490678,
0.0027101268,
0.0059937728,
-0.0035372542,
-0.0063385474,
-0.0028278143,
0.014851826,
-0.0054799262,
-0.013817502,
-0.0059904577,
0.009799553,
-0.0067197885,
-0.00878512,
0.01184831,
-0.009209459,
-0.014268362,
0.0044456027,
-0.0025808364,
0.010111176,
-0.007333089,
-0.055163927,
-0.0032388915,
0.006328602,
0.011172021,
0.011344409,
-0.007545258,
0.004286476,
0.0036466538,
-0.0054235687,
0.03296575,
-0.011994176,
0.007870141,
0.0108670285,
0.017769149,
0.021269936,
-0.0009928844,
-0.014493791,
0.018100664,
0.022927506,
0.023152936,
0.01518334,
-0.012365472,
0.03813737,
-0.0032935913,
-0.00082837057,
-0.0077507966,
-0.0039516464,
0.0008279562,
0.01587289,
0.031639695,
0.02157493,
0.0069352724,
0.03201099,
-0.0023769552,
-0.0007566807,
0.027555441,
0.021773838,
-0.00060252665,
-0.028881498,
0.0008851423,
-0.0016832622,
0.0064446316,
0.0072203744,
0.0127301365,
-0.025778526,
0.0007815442,
-0.0025675758,
0.001884657,
0.0006833332,
0.00050887396,
0.009070222,
-0.0150639955,
-0.058929924,
0.015766805,
0.0040278947,
-0.025645921,
0.0043063667,
0.0020951682,
-0.0061330087,
0.0041870214,
-0.0052080844,
-0.008029268,
0.022476647,
0.017490678,
0.005837961,
-0.005857852,
0.0007761571,
0.022198176,
-0.035697427,
0.012756658,
-0.021760577,
-0.010005092,
0.0010857083,
-0.010383017,
-0.035670903,
0.061582036,
0.010329976,
-0.012484817,
-0.0066501703,
-0.01518334,
-0.008977398,
0.0058711125,
-0.0050489577,
-0.01542203,
-0.02181362,
-0.0061562145,
-0.0093752155,
0.0040908824,
-0.0049660793,
0.044210706,
-0.0052975933,
-0.030976666,
-0.012398623,
0.014268362,
0.0019211235,
0.018458698,
0.041187298,
-0.009521081,
0.006421426,
0.006126378,
0.0030051742,
-0.010800726,
-0.012299169,
0.0067297337,
-0.020063225,
-0.0040179496,
-0.033973552,
0.0054699806,
0.005950676,
0.010581926,
0.019811274,
-0.0029073777,
-0.0100249825,
-0.0068689696,
0.005877743,
0.019957142,
0.02039474,
0.032196637,
0.021482106,
0.004346148,
-0.016748086,
-0.0056722043,
0.015077256,
-0.0016269048,
-0.024797246,
0.021190373,
0.0012017381,
-0.00497934,
0.019161507,
-0.012909154,
-0.024810506,
-0.0076712333,
0.008427085,
-0.010164219,
-0.0050158063,
0.016005496,
0.008347522,
0.010542144,
-0.009368585,
0.0037759442,
-0.01729177,
-0.010847137,
-0.0072203744,
0.010363127,
-0.030525807,
0.0017421059,
-0.019744972,
-0.001676632,
-0.0000022985832,
0.0123522105,
-0.002559288,
0.0039019196,
-0.008374043,
0.022940768,
-0.019267593,
-0.018710649,
-0.013711418,
-0.0039748526,
-0.02630895,
-0.0037659989,
-0.03625437,
-0.026812851,
-0.002754881,
-0.022317521,
-0.0127301365,
0.019493021,
-0.020911902,
-0.026958717,
0.015329206,
-0.0265609,
0.024014873,
0.008844793,
-0.012047218,
0.015567896,
0.021177113,
-0.005997088,
-0.026879154,
0.0055395984,
-0.023603795,
-0.0052777026,
-0.004770486,
-0.023948569,
-0.028165428,
0.0049660793,
-0.0025526576,
0.0256194,
0.014175538,
-0.0035836662,
0.0018432178,
-0.009083483,
0.0050456426,
0.024571816,
0.0017421059,
0.014745742,
-0.00021900643,
0.0100249825,
-0.023086634,
0.010270303,
-0.024943111,
0.0014503737,
0.0058677974,
0.0018282996,
0.010515624,
-0.029597567,
-0.011782006,
-0.0066932673,
0.0003302708,
-0.0069750543,
-0.009063592,
0.040948607,
0.021720795,
-0.031241877,
0.021906443,
0.014798784,
-0.016721565,
0.011092458,
-0.005745137,
0.025234845,
0.009627166,
-0.034769185,
0.03540569,
0.007233635,
-0.02917323,
-0.0057219313,
0.004193652,
-0.0009771375,
0.039993845,
0.0015117037,
-0.025049197,
-0.035883073,
-0.0032935913,
-0.014719221,
0.0044688084,
-0.000073865456,
-0.013452837,
-0.022980548,
0.00038372743,
-0.019851057,
0.008480128,
-0.014069453,
-0.03132144,
-0.011755486,
-0.0051815636,
0.0028841717,
0.019996922,
-0.02205231,
-0.008181765,
-0.0059142094,
-0.034053117,
-0.029518005,
-0.0024482307,
-0.012842852,
0.0043129968,
0.042699,
0.035485256,
0.039251257,
0.017132642,
0.022118613,
0.0033864153,
0.0051053152,
0.012087,
-0.0069750543,
0.01894934,
-0.0075054765,
0.020606909,
0.017013296,
0.007425913,
0.033310525,
-0.005977197,
0.029942343,
0.004435657,
0.004412451,
-0.032276202,
0.0038090956,
-0.02771457,
-0.027157625,
0.004886516,
0.0074656946,
-0.0028543354,
-0.05792212,
0.0052014543,
0.015952453,
0.012219605,
-0.0020189201,
0.00003475717,
0.028801935,
0.0028957746,
0.029040625,
0.00973988,
0.014122495,
-0.009872486,
-0.007478955,
0.010986373,
0.011231693,
0.025301147,
-0.01162288,
0.0026040422,
-0.001861451,
-0.025685703,
-0.01727851,
-0.0047108135,
-0.018418917,
-0.016310487,
0.014745742,
-0.0055760653,
0.0022990494,
-0.022025788,
-0.020235613,
-0.040656876,
0.0156209385,
0.016191144,
-0.014984432,
0.022688817,
0.0051848786,
-0.016323749,
0.03270054,
0.01184831,
0.019267593,
-0.037315212,
0.026123302,
0.006895491,
-0.0072203744,
-0.0095542325,
0.003167616,
0.0014122495,
-0.0040345252,
0.039092127,
0.030870581,
-0.00077367073,
-0.018936079,
-0.011596359,
-0.005102,
-0.01853826,
-0.026136562,
0.025725484,
0.0018597934,
0.01232569,
-0.0062987655,
-0.013108063,
-0.013830763,
0.024094436,
-0.005118576,
-0.0068822303,
0.008393934,
-0.018525,
-0.016310487,
-0.0045119054,
0.0002805437,
0.030658413,
0.00901055,
-0.018816734,
-0.000791904,
-0.018922817,
0.015276164,
-0.0027399631,
0.014931389,
0.012179824,
-0.0041174036,
0.0032471793,
0.0051517272,
0.016416572,
-0.023126416,
-0.01828631,
-0.0028990898,
0.037156086,
-0.0012945621,
-0.008201656,
0.007618191,
0.000209061,
0.0007086111,
-0.006948533,
-0.0028825141,
0.0066932673,
-0.039410383,
-0.0121731935,
0.026826112,
0.006232463,
-0.0026189603,
0.014931389,
-0.025208322,
-0.002381928,
-0.022609252,
-0.0113311475,
0.004336203,
-0.037341736,
-0.03771303,
0.014440749,
0.011974284,
0.014387706,
0.0034576908,
-0.015581157,
0.010237152,
0.017915016,
-0.0052379207,
-0.0031543556,
-0.0036930656,
0.009308913,
-0.022237958,
-0.0061595296,
0.0037162716,
-0.02442595,
0.0052478663,
-0.028616287,
-0.019851057,
0.014042933,
-0.01494465,
0.003210713,
0.017238727,
-0.0365461,
0.026852632,
-0.0059341,
0.019042162,
0.005652313,
-0.013631855,
0.0045119054,
-0.00971999,
-0.002265898,
-0.0066236495,
0.0110526765,
-0.01945324,
0.0067894063,
-0.042699,
0.012856112,
-0.0055296533,
-0.026892414,
-0.021190373,
0.009507821,
-0.012696985,
-0.025924394,
-0.020752775,
-0.0010915098,
-0.019532803,
0.0066070734,
-0.0005565291,
-0.020978205,
0.004014634,
-0.001518334,
-0.010535514,
0.003094683,
-0.026269168,
-0.005947361,
-0.009441518,
-0.031082751,
-0.011589728,
-0.0052379207,
-0.019294113,
0.02845716,
0.030207554,
-0.009149786,
-0.017968057,
0.013001978,
-0.042752042,
-0.029597567,
-0.0175835,
0.0006999089,
0.0154352905,
0.0134793585,
-0.0025493426,
0.017623283,
0.0020288655,
0.0023504342,
-0.010376387,
-0.009938789,
0.030950146,
-0.02469116,
0.017636543,
0.01351251,
-0.025818309,
-0.019718451,
0.018299572,
0.004008004,
-0.019638889,
0.021256676,
-0.027635004,
0.01566072,
-0.0270648,
0.008645885,
0.016482875,
-0.011430602,
0.03511396,
-0.029809738,
-0.013472728,
-0.019744972,
-0.017517198,
-0.02062017,
0.023988351,
0.005496502,
0.007240265,
-0.005645683,
0.015740283,
-0.01422858,
-0.001977481,
-0.016204404,
0.016138101,
0.008334261,
0.00010867442,
0.007777318,
0.031135792,
-0.008732079,
-0.017689586,
-0.017450895,
-0.00759167,
-0.014400967,
-0.0018050936,
-0.023086634,
-0.0042599547,
-0.012624052,
-0.003885344,
-0.031719256,
0.017477417,
-0.018989122,
-0.02063343,
0.0060600755,
-0.00065349694,
0.020726254,
0.011357669,
-0.008234807,
0.004551687,
-0.011881461,
-0.010522254,
-0.0016260761,
-0.015302685,
0.00735298,
-0.020898642,
0.030737976,
-0.024704421,
0.0069617936,
0.020819077,
-0.020712994,
0.0041273492,
-0.0039019196,
0.20654647,
0.0012929045,
0.0032190008,
-0.0048533645,
0.010608448,
-0.0020703047,
-0.00029401146,
0.01280307,
0.0027615114,
0.0147855235,
0.030976666,
0.0107742045,
-0.014851826,
-0.009275761,
-0.0034808968,
-0.005791549,
-0.022145133,
-0.0043693543,
-0.047525845,
-0.009017181,
0.011085828,
-0.012624052,
0.022118613,
-0.0043792995,
0.03869431,
-0.0051550423,
-0.0403121,
-0.00439256,
-0.017437635,
0.006093227,
0.0030515862,
-0.004836789,
-0.008029268,
0.022927506,
-0.002778087,
0.013910326,
0.0009862541,
0.009043701,
-0.012365472,
0.0037858896,
-0.0032521521,
-0.0018896296,
-0.038004763,
-0.0024001612,
0.0070214663,
0.003911865,
0.014997693,
-0.030127991,
-0.016535917,
0.025526576,
-0.014215319,
0.0014437434,
0.0078171,
0.018379135,
-0.009216089,
-0.023351844,
-0.0017669694,
0.01731829,
0.007565149,
0.015050734,
-0.014400967,
0.013466097,
-0.01257101,
0.022914246,
-0.025672443,
0.038853437,
-0.01256438,
0.0019741657,
0.03057885,
-0.037845634,
0.022357302,
-0.025195062,
-0.00900392,
0.009076852,
-0.023418147,
-0.022370564,
0.032594454,
0.018326093,
0.020341698,
0.02465138,
0.005808125,
-0.005692095,
-0.03291271,
0.017477417,
-0.004555002,
-0.018127184,
0.0063020806,
0.009302282,
-0.008592842,
-0.024067914,
0.010349866,
-0.021986008,
-0.015395509,
0.006716473,
0.02536745,
0.021004725,
-0.013492619,
-0.022304261,
-0.0062026265,
0.0063418625,
-0.028112385,
0.055853475,
0.008725448,
0.019280853,
-0.028138906,
0.0052246605,
-0.018816734,
0.026043737,
-0.006093227,
-0.004578208,
-0.0136583755,
-0.0030151196,
0.010688011,
-0.008758599,
0.0045881537,
0.029995386,
0.012902524,
-0.014586615,
0.014520313,
-0.0024449155,
-0.0046378807,
-0.01636353,
0.022582732,
0.030684933,
-0.0074590645,
-0.0046842927,
-0.024518773,
-0.0068225577,
0.018922817,
-0.04230118,
0.008818272,
0.030313639,
0.013306971,
-0.013645115,
0.004193652,
0.0064479467,
0.014149017,
-0.014493791,
-0.022715338,
0.0009854253,
-0.014599876,
-0.011549947,
0.017848713,
0.010767574,
-0.011191912,
0.014347925,
0.034450933,
0.019307375,
-0.023869006,
-0.017755888,
0.0042699,
-0.02345793,
0.015196601,
-0.014652918,
0.024929851,
-0.011344409,
-0.016018756,
-0.013910326,
0.008195026,
-0.023166196,
-0.044635043,
0.0026968662,
0.015859628,
-0.019771494,
-0.01943998,
0.002323913,
-0.16612828,
0.014904869,
0.020712994,
-0.024916591,
0.023166196,
0.003603557,
0.008944247,
0.0032952488,
0.008327631,
-0.0005726904,
0.05527001,
-0.0150639955,
-0.02300707,
-0.00497271,
-0.003911865,
0.027210668,
0.012975457,
0.02205231,
0.0043030516,
0.008911096,
0.00290572,
-0.008864684,
-0.0067330487,
-0.01587289,
0.020580389,
0.0033433184,
0.025712224,
-0.0055263382,
-0.024823766,
-0.0059705665,
0.004412451,
-0.009600645,
0.052750506,
0.0048500495,
0.024160739,
0.00096056174,
-0.0051782485,
0.013737939,
0.005881058,
0.021853402,
0.023789443,
0.036121763,
-0.0024880124,
0.024916591,
-0.012663834,
0.030260596,
0.0058644824,
0.005891003,
0.040709917,
-0.0005519708,
0.038084324,
-0.012895893,
0.02087212,
0.03678479,
0.036095243,
0.03182534,
0.007299938,
0.0023023647,
0.009388476,
-0.020487564,
0.0077375364,
0.0011868201,
0.032780103,
0.0002813725,
0.0032272886,
-0.027104583,
0.0035936115,
0.03463658,
-0.036121763,
0.029067146,
-0.018790212,
-0.008579582,
0.009096744,
-0.04028558,
0.009202828,
0.029968863,
-0.015461812,
0.010144328,
0.021190373,
-0.009521081,
-0.026123302,
0.02014279,
-0.024916591,
-0.0039682225,
-0.010966483,
-0.010701271,
0.0043196273,
-0.0059904577,
-0.013857285,
0.0034643211,
0.0156342,
-0.01566072,
0.0016865773,
-0.020487564,
0.03840258,
0.034530494,
0.001190964,
-0.0036068722,
-0.007856881,
0.007611561,
0.021322979,
-0.0058445917,
-0.017145904,
0.017689586,
0.0002855164,
-0.0064578922,
0.0017934906,
0.0017570241,
0.036174804,
-0.030737976,
-0.008387304,
-0.011410711,
0.020474304,
0.04394549,
-0.01824653,
0.043706805,
0.0130086085,
-0.0017039819,
0.013684897,
-0.0149711715,
0.061847247,
0.010562035,
0.018631086,
0.021999268,
-0.018060882,
-0.033973552,
-0.13971326,
0.0042732153,
0.012378732,
0.0365461,
-0.0052114,
-0.0034079638,
-0.0033582365,
0.019784754,
-0.023338584,
0.008460237,
-0.0057550827,
0.00783036,
0.001849848,
-0.016151361,
0.007611561,
0.00010390891,
-0.009899007,
0.004100828,
-0.037819114,
0.027608484,
-0.00651425,
-0.010595187,
0.0008984029,
-0.016469615,
0.0026471391,
0.028085865,
-0.022675555,
0.027528921,
-0.0036599142,
0.014095974,
-0.0015208204,
-0.023418147,
0.021389281,
0.014825305,
-0.020580389,
-0.008645885,
0.005841276,
-0.01233232,
0.009037071,
-0.023683358,
0.007677864,
-0.022569472,
-0.014520313,
-0.01921455,
-0.0066998973,
-0.00878512,
-0.02705154,
0.0156342,
0.01517008,
-0.023564013,
-0.029332357,
-0.018060882,
-0.019758234,
-0.030234074,
0.030287117,
-0.011225063,
0.015541376,
0.014308143,
-0.045138944,
-0.021243416,
-0.03392051,
-0.015806586,
-0.02112407,
-0.005884373,
0.012783179,
-0.00044795827,
-0.032541413,
-0.009216089,
0.02632221,
-0.020964945,
0.011549947,
0.0028128962,
-0.0146927,
-0.017039819,
-0.0123522105,
0.009792923,
-0.005953991,
0.005290963,
0.0033897304,
-0.025287887,
-0.020288656,
-0.024863549,
0.013068281,
-0.003214028,
0.0050158063,
-0.0011520111,
0.012073739,
-0.018047621,
0.021919705,
-0.023975091,
0.0008760257,
0.0659315,
0.03036668,
-0.008082311,
-0.016164621,
0.018060882,
-0.0056191618,
-0.004525166,
0.004859995,
0.015117037,
-0.042566396,
-0.009527712,
-0.058664713,
-0.00040403267,
0.008818272,
0.0128097,
0.031215357,
-0.00592747,
0.0045682625,
0.0058677974,
0.00876523,
0.007909924,
-0.00038662818,
0.004962764,
-0.0074590645,
0.0013724678,
-0.015236382,
-0.023590535,
0.05381135,
0.0012688697,
0.01921455,
0.023815963,
-0.008413825,
0.0038223562,
-0.017106121,
0.008745339,
-0.0060600755,
-0.014281622,
-0.015488333,
0.004879886,
0.009521081,
0.011470384,
-0.004001374,
-0.037156086,
-0.015103777,
-0.0100249825,
-0.017106121,
-0.0155281145,
-0.01422858,
0.012199715,
0.0030300377,
0.014082714,
0.004909722,
-0.021057768,
0.018312832,
-0.0035372542,
0.029040625,
0.0007608246,
-0.033098355,
-0.021482106,
0.018790212,
-0.0062059416,
0.03461006,
-0.0015937535,
0.0055296533,
-0.017716108,
-0.0057583977,
0.009235979,
0.023975091,
-0.030419722,
0.00059133803,
-0.0069684237,
0.020063225,
0.0050589032,
0.004770486,
0.006421426,
0.008957508,
0.007943075,
-0.034477454,
0.014825305,
0.0153424665,
-0.0019708506,
0.0007624822,
-0.025340928,
-0.0003250909,
0.011430602,
-0.0058280155,
0.017437635,
-0.018074142,
-0.0001651354,
-0.019758234,
0.022304261,
0.03678479,
0.00040341108,
-0.013618594,
0.0047307042,
0.0019990292,
-0.004743965,
-0.017092861,
0.017702846,
0.011914613,
0.002416737,
0.017437635,
0.025327668,
0.00225098,
-0.007147441,
-0.0246779,
0.0038223562,
0.0034245395,
0.009600645,
0.004429027,
0.034132678,
-0.0032272886,
-0.007432543,
0.0005735192,
0.003819041,
-0.029438442,
0.024969634,
-0.005741822,
-0.030737976,
-0.005881058,
-0.0115167955,
0.018312832,
0.0037096415,
0.017517198,
-0.0052544964,
0.0047307042,
0.0045649474,
0.017132642,
-0.0061330087,
-0.008592842,
0.033973552,
-0.016960256,
-0.019718451,
0.0022642405,
-0.021442324,
0.02248991,
0.016085058,
0.018564783,
-0.020408,
0.03532613,
-0.036201328,
0.007372871,
0.002454861,
-0.032276202,
-0.01448053,
0.008466867,
0.0029836257,
-0.009985201,
0.030817538,
-0.012053848,
0.09070222,
0.013698158,
-0.020209093,
0.0022609252,
-0.0035538299,
-0.0023719824,
0.0054699806,
0.018578043,
-0.014560094,
-0.029332357,
0.015382249,
-0.016774608,
0.0011901351,
-0.01894934,
-0.020010184,
0.02607026,
-0.012756658,
0.027316751,
-0.0075518885,
-0.020461043,
0.017013296,
-0.014546833,
-0.01518334,
-0.0040312097,
-0.043759845,
0.00879175,
0.022980548,
-0.0029156655,
0.0043030516,
-0.022357302,
-0.014838566,
-0.010177479,
-0.007989487,
-0.0019260962,
0.011576468,
-0.01280307,
-0.016748086,
-0.03895952,
-0.0053307447,
0.050071873,
0.0013384877,
0.0065374556,
-0.023789443,
0.0026653723,
0.007989487,
-0.024359647,
-0.0154352905,
-0.0012779863,
-0.010741053
] |
The aim of this paper is to review the clinical epidemiology of heart failure. The last paper comprehensively addressing the epidemiology of heart failure in Heart appeared in 2000. Despite an increase in manuscripts describing epidemiological aspects of heart failure since the 1990s, additional information is still needed, as indicated by various editorials. | [
-0.00002811772,
0.0012365908,
0.008988249,
-0.042409964,
0.007951868,
0.029094039,
-0.013918909,
0.020903489,
-0.028993541,
-0.012800874,
-0.023290304,
0.0128259985,
0.00086757645,
0.02268732,
-0.017951373,
0.015501746,
0.04783683,
-0.0097105745,
0.0013622128,
-0.006538621,
-0.031933095,
0.018918661,
-0.013416422,
0.0027024418,
-0.016695155,
0.027109211,
0.01151325,
-0.022034086,
-0.009666608,
-0.01839105,
-0.00853601,
-0.0018544937,
-0.03522439,
-0.005866544,
-0.015866049,
-0.0008330304,
-0.0057817493,
-0.0028955855,
0.017938811,
-0.027661948,
0.018579483,
0.00899453,
-0.017059458,
0.0013449398,
0.001672342,
-0.0070097037,
0.030827621,
-0.024822893,
-0.022084335,
0.024647022,
0.0032441863,
0.0106904255,
-0.01827799,
-0.0009767105,
0.014647516,
-0.016808214,
-0.0071918555,
0.022473762,
0.011777055,
-0.045349516,
-0.0053075263,
-0.009427926,
-0.01501182,
-0.0099681,
-0.011959207,
0.0029238504,
-0.0011659286,
0.01288881,
0.005163061,
0.011827304,
0.018290553,
0.015677616,
-0.018466422,
0.0069343303,
0.029345281,
-0.013868661,
-0.0018811884,
-0.018855851,
-0.009836197,
0.01615498,
-0.0064946534,
0.0018592045,
-0.0016425067,
0.016996646,
0.00853601,
0.006171177,
0.015903736,
0.0003542931,
-0.012694095,
-0.0040199016,
-0.012939058,
-0.0030620345,
-0.0134917945,
0.0015027523,
0.009679169,
0.0063282046,
0.0034703058,
0.017172517,
0.014660079,
-0.021958712,
-0.021971274,
0.012241857,
-0.024320405,
0.0013794858,
-0.02354155,
0.007757154,
0.008824941,
-0.020526623,
0.0028908746,
-0.015313312,
-0.019546771,
0.02062712,
-0.0112306,
-0.0040293233,
0.01277575,
-0.022323016,
-0.00047540048,
0.0024433464,
0.0102005005,
-0.033742048,
0.031229611,
0.0124051655,
0.035500757,
-0.041907474,
-0.012876247,
-0.01845386,
-0.044093296,
-0.011695402,
0.028440803,
-0.00038825028,
-0.020601995,
-0.00083774125,
0.021192418,
0.0042994106,
-0.018579483,
-0.0072609475,
-0.015137442,
0.00945305,
-0.008856346,
-0.044545535,
-0.005505381,
0.030953243,
-0.009063622,
-0.029470904,
-0.00292228,
0.0138058495,
0.03138036,
0.008498323,
0.024709834,
-0.011017043,
0.0040293233,
0.002496736,
0.0049871905,
0.02492339,
-0.014597268,
0.013378736,
0.0031248454,
0.0021779703,
-0.007229542,
-0.03766145,
-0.004434454,
-0.006262253,
0.008184268,
-0.0068903626,
-0.0076629375,
0.01335361,
0.019169906,
-0.008328734,
0.023755107,
-0.025250006,
-0.024772644,
0.04112862,
-0.009346271,
0.0044093295,
0.013554606,
0.010131408,
0.010162814,
0.01845386,
-0.031304985,
-0.025677122,
0.000045317127,
0.016092168,
0.037259463,
0.014974134,
-0.011450439,
0.008938001,
0.024094285,
-0.040927622,
0.02056431,
-0.017411198,
0.0074054124,
0.026154485,
0.0069594546,
0.011155227,
-0.64800817,
-0.01959702,
-0.016632343,
-0.020601995,
0.0036241927,
-0.0017163096,
0.027586576,
-0.0004002236,
-0.01357973,
0.01667003,
-0.018014185,
0.003957091,
0.015313312,
-0.0015082483,
-0.023202369,
-0.009132714,
-0.020099508,
-0.026556475,
-0.00067521783,
-0.009296022,
-0.009503298,
0.027511202,
-0.017951373,
0.021242667,
0.0010622904,
0.006111507,
0.014521895,
-0.025086699,
0.011500687,
0.021594409,
-0.0069971415,
0.01971008,
-0.011701683,
0.001810526,
0.040827125,
-0.03364155,
-0.019358339,
0.000049782597,
0.021054234,
0.026782595,
-0.0058759656,
0.0054614134,
0.01512488,
-0.006205723,
-0.0027118633,
0.005810014,
0.02440834,
0.008429231,
0.01615498,
0.011192914,
-0.009264617,
-0.017448885,
-0.020551747,
0.011437876,
-0.0029725288,
-0.0017634179,
0.0065511833,
-0.023792792,
-0.010589928,
0.008039803,
0.0029552558,
-0.0046166056,
-0.035299763,
-0.0045380923,
0.0058634034,
0.012876247,
-0.019006597,
0.014572144,
0.011048448,
-0.010571085,
0.004013621,
0.031556226,
-0.011594904,
0.0068338327,
0.0439928,
-0.0042146156,
0.013755601,
0.013868661,
-0.01660722,
0.0027683931,
-0.0004848221,
0.027084088,
-0.012461695,
0.020890927,
-0.002451198,
-0.009057341,
-0.021757718,
0.00019608797,
-0.016355975,
0.007882776,
0.008567415,
0.01913222,
0.010213063,
-0.009892726,
-0.004315113,
0.02561431,
0.006375313,
0.00802096,
0.008429231,
-0.0029945127,
-0.0016974662,
-0.036078617,
0.008184268,
-0.007631532,
-0.0122292945,
0.026883092,
-0.009013373,
0.0074054124,
0.048163448,
-0.011268287,
0.017172517,
-0.021506473,
-0.020815553,
0.0071416064,
-0.007229542,
-0.028792545,
0.005420586,
0.0032818727,
0.011795899,
-0.012782031,
0.045525387,
-0.002985091,
0.018466422,
-0.013039556,
-0.0022721866,
0.013227989,
-0.03318931,
-0.012380041,
-0.03615399,
-0.037158966,
0.02532538,
-0.03798807,
0.041605983,
0.0021921026,
-0.0045475136,
-0.0099681,
0.038691554,
0.0068778004,
0.012254419,
-0.011262006,
0.000716045,
-0.009101309,
0.008460637,
0.0022549136,
-0.022988813,
-0.019358339,
0.007041109,
-0.011569779,
-0.009540985,
0.008812378,
-0.021858215,
-0.02503645,
0.007901619,
0.01816493,
0.002583101,
-0.003822047,
0.01220417,
-0.025224883,
-0.027234834,
-0.03253608,
0.038993046,
0.029496029,
-0.017109707,
0.01850411,
-0.004337097,
-0.005546208,
-0.028742297,
0.008146582,
0.0057157977,
-0.02548869,
0.013969158,
0.0051253745,
-0.006777303,
0.0096037965,
-0.005631003,
0.01420784,
0.0021591268,
-0.019458836,
-0.018064434,
-0.017423762,
0.009515861,
-0.01689615,
0.0014925455,
0.004148664,
0.014459084,
0.0045475136,
0.035626378,
0.0075247535,
-0.0043402375,
0.019119658,
-0.0054802564,
0.023265181,
-0.025526375,
0.0098864455,
-0.005115953,
0.0026741768,
-0.011682839,
0.006538621,
0.0057315,
0.024207346,
0.032058716,
-0.033139065,
0.010564804,
-0.017662443,
0.008385263,
-0.0061272094,
0.010307279,
0.010470588,
0.044369664,
-0.004858428,
-0.0031185644,
0.004302551,
-0.010809767,
-0.0066139945,
-0.015941422,
0.018629732,
0.010571085,
-0.01185871,
-0.021682344,
0.0021355727,
-0.0005649061,
0.0012632855,
0.0075812833,
0.016720278,
0.004519249,
0.0025045872,
0.017561946,
0.013202865,
0.009779667,
-0.02738558,
-0.016004233,
0.010916545,
0.0073174774,
0.02447115,
0.01673284,
0.014346024,
0.0141199045,
-0.01752426,
0.008737005,
0.030274885,
0.004060729,
0.015275626,
0.011236881,
-0.0021732594,
-0.005938777,
0.005247856,
0.006576308,
0.010577367,
0.013680228,
0.005907371,
-0.00802096,
0.009547266,
0.004682557,
-0.0077257487,
-0.0026254982,
-0.013554606,
0.016079606,
-0.0052918238,
0.025601748,
0.03213409,
0.033943046,
0.0043967674,
0.010966795,
-0.012235575,
-0.0015632078,
-0.005596457,
-0.023667172,
0.006343907,
-0.008686756,
-0.014949009,
-0.0358525,
0.0015530011,
0.015803238,
-0.039219167,
0.010288436,
0.01752426,
0.026732346,
-0.0027134337,
0.012304667,
-0.009804792,
-0.019546771,
-0.008887751,
-0.0026097954,
0.009051059,
0.008152863,
-0.008787254,
0.028290058,
0.017876001,
-0.031028615,
0.02801369,
0.013504357,
-0.00412668,
-0.016117293,
-0.021443663,
-0.010878859,
0.0137681635,
0.024810331,
-0.008435512,
-0.001398329,
0.011726807,
-0.0016126715,
-0.029370407,
-0.019119658,
-0.043967675,
0.033541054,
0.014848512,
-0.00020884645,
-0.0041109775,
-0.0026851688,
0.0060518365,
-0.0038126255,
-0.021179857,
0.003677582,
0.0021512755,
0.0077822786,
0.0038408905,
-0.002727566,
0.021845654,
0.0389428,
-0.030928118,
0.002050778,
-0.020350752,
-0.016833339,
-0.009145277,
0.059695538,
0.017448885,
0.0014713468,
0.013378736,
0.035551004,
-0.011104979,
0.017197642,
-0.018290553,
0.013956596,
0.013152616,
0.008956843,
-0.019986449,
0.0015427943,
-0.00064106437,
0.019609584,
0.017046895,
-0.00899453,
-0.006915487,
-0.006124069,
0.013479233,
-0.006840114,
-0.007769716,
0.032686826,
0.021380851,
0.021192418,
-0.011965488,
0.009804792,
0.012342354,
0.019458836,
0.016808214,
-0.013265676,
0.013906348,
-0.003489149,
0.02526257,
0.006639119,
0.028139312,
0.0060015875,
-0.025677122,
0.017310701,
0.0015804808,
0.010489431,
-0.006852676,
0.0038251877,
0.009873884,
0.0017869719,
-0.0062182853,
0.016293164,
0.019609584,
0.006444405,
-0.027762447,
0.014044532,
0.0017854016,
-0.019873388,
-0.024722395,
0.02561431,
-0.0023381382,
0.006519778,
-0.010093722,
-0.015665054,
0.013102367,
-0.020074384,
-0.011934083,
-0.013655104,
0.016004233,
-0.0119843315,
-0.015665054,
-0.03431991,
-0.017599631,
-0.017059458,
-0.008862627,
0.01770013,
-0.02286319,
0.0045475136,
0.022134583,
0.008196831,
0.007895338,
0.019282965,
-0.012323511,
-0.0063690315,
-0.0070599522,
-0.0065637454,
0.012197889,
-0.003712128,
-0.024659583,
-0.013717914,
-0.0033007162,
-0.031355232,
-0.037937824,
0.011098697,
0.026757471,
0.0048207412,
0.003649317,
0.025074137,
0.014634955,
-0.022373265,
0.010860016,
0.008234518,
0.030902995,
-0.021895902,
-0.025576625,
0.0047328062,
-0.008014679,
-0.00072350376,
-0.013227989,
-0.00423974,
-0.0035770843,
0.0029898018,
-0.005561911,
0.01317774,
-0.009729418,
0.022335578,
-0.008039803,
-0.0016990366,
0.016745403,
0.034018416,
0.026631849,
-0.0016189526,
0.013202865,
0.021217544,
-0.016406223,
-0.0069971415,
0.0057032355,
0.013102367,
-0.0076503754,
-0.03168185,
0.011525812,
0.0026145063,
-0.032837573,
-0.053715937,
-0.004051307,
-0.005894809,
0.03168185,
0.006309361,
-0.016067045,
-0.046706233,
0.011525812,
-0.01827799,
0.00068503205,
0.0015051077,
-0.018717667,
-0.0046103247,
-0.02308931,
-0.020275379,
-0.016142417,
0.029948268,
-0.02921966,
0.016293164,
-0.0072735096,
-0.0036681602,
-0.012656409,
-0.0036744413,
-0.016167542,
-0.0067647407,
0.0104454635,
-0.023013936,
-0.014597268,
-0.003225343,
-0.008837502,
0.031254735,
0.019144781,
0.011318536,
-0.0014988267,
0.008284766,
-0.003787501,
-0.0044438755,
0.010589928,
-0.002416652,
0.006249691,
-0.00029344496,
0.046429865,
0.01563993,
-0.0023004515,
0.0030337695,
-0.010508274,
0.020614559,
-0.0048050387,
-0.012436571,
-0.018931225,
-0.024885703,
-0.038415186,
-0.015225378,
0.0027589716,
-0.020991424,
0.018315677,
-0.034696776,
-0.0012420868,
0.007819965,
0.00567183,
-0.022662196,
-0.018830726,
0.012053424,
0.00030973656,
0.018767916,
-0.0021340025,
-0.014232964,
-0.023956101,
-0.007242104,
-0.02394354,
-0.0028924448,
0.013428984,
-0.0066454,
0.009924132,
0.0052447156,
-0.021682344,
0.008981967,
0.011086135,
-0.015652493,
0.0061617554,
-0.0064820913,
-0.019345777,
0.01162631,
-0.0029254206,
0.008950562,
-0.019860826,
0.010093722,
0.014697765,
-0.0011125392,
0.02074018,
-0.01655697,
-0.011167789,
-0.0127192205,
-0.021908464,
0.005609019,
-0.0033729486,
0.03426966,
0.012939058,
-0.03248583,
-0.04313857,
0.0035990681,
-0.012436571,
0.018529234,
0.01094167,
-0.0104454635,
-0.008353858,
0.005822576,
0.010363809,
0.04326419,
-0.0109353885,
-0.030400507,
0.025086699,
0.018328238,
-0.0265816,
-0.016242916,
0.0034420409,
-0.009905289,
0.015778113,
-0.0031389778,
0.0023098732,
-0.018855851,
-0.04600275,
-0.009402801,
0.026254982,
-0.016707717,
0.023843043,
0.0072797905,
-0.019747768,
-0.006896644,
-0.018667419,
0.0064067184,
0.0051473584,
-0.013592293,
0.007863932,
-0.03426966,
-0.01924528,
0.012342354,
-0.008642789,
-0.010401496,
-0.0029552558,
-0.016469035,
0.028867919,
-0.0011494406,
-0.014572144,
0.032686826,
-0.008956843,
0.0154138105,
0.002606655,
-0.0027291363,
-0.037510708,
0.0037152686,
-0.013881223,
0.009754542,
0.023579236,
-0.00023671881,
0.01552687,
-0.013881223,
-0.025601748,
-0.009729418,
-0.024131972,
0.00085579936,
-0.015200254,
-0.021029111,
-0.016129855,
-0.010231906,
0.011751931,
0.041329615,
0.0030039344,
0.0065637454,
0.016720278,
-0.012901372,
0.012103673,
-0.001942429,
-0.009767105,
0.00041494492,
0.0038377498,
-0.027486078,
-0.01782575,
0.014810825,
0.004060729,
-0.030375382,
-0.03258633,
-0.00028029393,
0.01655697,
-0.016431348,
0.004337097,
0.005813155,
0.018114682,
-0.0037623767,
-0.01317774,
-0.022335578,
0.056127876,
-0.026682097,
0.010288436,
0.040977873,
-0.009647764,
0.004428173,
-0.022184832,
0.014145029,
0.0011533663,
-0.013127491,
-0.019634707,
-0.041153744,
0.011764494,
-0.026631849,
-0.011274568,
-0.017486572,
-0.014371148,
0.0030431913,
0.014974134,
0.01982314,
0.007424256,
-0.004629168,
0.012116235,
0.0062936586,
0.0038722958,
0.007185574,
-0.027661948,
-0.004704541,
0.008517167,
-0.038716678,
-0.0062214257,
-0.00042750713,
0.043816928,
0.030802496,
-0.0038628743,
-0.026983589,
-0.0038126255,
-0.04896743,
-0.000092057315,
-0.000033564607,
0.041329615,
-0.0023161543,
-0.0021842513,
0.013642541,
0.012254419,
-0.021795405,
0.012518225,
-0.018064434,
-0.01713483,
0.0040764315,
-0.018064434,
0.006089523,
-0.010326122,
-0.026782595,
-0.0022030945,
0.052258722,
0.0105522415,
-0.013265676,
0.011142665,
0.005260418,
-0.004428173,
-0.02926991,
-0.0068087084,
-0.017247891,
0.0038314688,
0.00014260052,
-0.028340306,
0.00067678816,
0.008335015,
-0.013215426,
-0.015991671,
0.017800627,
0.017436324,
0.00020845389,
0.009691732,
-0.02881767,
-0.03442041,
-0.008799816,
-0.017310701,
-0.00058257167,
0.0055650515,
-0.01999901,
0.028239809,
0.0033132783,
0.02315212,
-0.005351494,
0.006375313,
-0.0069343303,
0.011777055,
0.010834891,
0.010721832,
-0.023755107,
-0.0061963014,
-0.006011009,
-0.014534457,
-0.021895902,
-0.027611699,
-0.039445285,
0.0035645221,
0.015840925,
0.0055085216,
-0.014157591,
-0.020011572,
0.0037969227,
-0.034646526,
-0.00876841,
-0.008850065,
0.007417975,
-0.012901372,
0.0010214633,
-0.00016340664,
-0.00842295,
0.013064681,
-0.0061963014,
-0.0036524576,
-0.0055713323,
0.035324886,
0.20159806,
-0.03087787,
0.00064499007,
0.0029693884,
-0.0141199045,
0.0077822786,
0.0045129675,
-0.0058759656,
-0.013341049,
0.01489876,
0.016682591,
-0.010282155,
-0.035877623,
0.0057377815,
0.013705352,
-0.03364155,
-0.04957041,
-0.016054483,
-0.01621779,
0.01174565,
-0.00601729,
0.005602738,
0.0027574012,
-0.0023852463,
0.04617862,
-0.031405482,
-0.0143209,
0.006331345,
0.03630474,
-0.012951621,
-0.0047359467,
-0.015363562,
0.0062308474,
0.025626874,
-0.018541796,
0.0019801157,
0.026782595,
-0.0052572777,
0.031355232,
0.0014807684,
0.00025340298,
0.004892974,
-0.0049306606,
-0.017750379,
0.02670722,
0.0327622,
0.0072797905,
-0.010451744,
-0.010803485,
-0.0041737887,
-0.04321394,
-0.016368536,
0.0116011845,
0.011431595,
-0.0033038566,
0.015476622,
0.013378736,
0.013341049,
-0.00933999,
-0.001970694,
0.010922827,
-0.003099721,
-0.0012507233,
0.024157096,
-0.022511449,
0.041455235,
-0.017775502,
-0.026757471,
0.00084637775,
-0.0007195781,
0.0149238845,
-0.030450756,
-0.033666678,
0.00050562824,
0.00670193,
-0.002831204,
0.019119658,
0.013328486,
-0.0035896467,
0.02457165,
-0.012047143,
-0.0086239455,
-0.037209217,
0.004921239,
0.0081403,
-0.029345281,
0.01861717,
0.0026616147,
-0.025752494,
-0.0068149897,
-0.020953737,
0.019948762,
-0.018102119,
-0.006714492,
0.031732097,
0.0035990681,
0.00015427943,
0.010319841,
-0.011519531,
-0.006296799,
-0.003580225,
0.07899107,
0.0054237265,
0.0017430042,
0.016644904,
-0.0047359467,
-0.02921966,
0.024320405,
0.018767916,
-0.014408835,
0.033666678,
-0.035952996,
0.0019518507,
-0.041907474,
0.000058787136,
0.012292106,
0.012744345,
-0.00059395615,
0.005178764,
-0.038591057,
-0.027008714,
-0.010784643,
0.0026914498,
0.039947774,
-0.010056036,
-0.015212815,
0.023855604,
-0.00847948,
0.005838279,
-0.02469727,
0.022549136,
-0.018441299,
-0.009182963,
0.013705352,
0.013026994,
-0.015162567,
-0.000426722,
0.010872577,
-0.00029226727,
0.026682097,
-0.011777055,
-0.02509926,
0.019772891,
0.030626625,
0.0062685343,
0.0017320123,
0.008404107,
-0.008316171,
0.0158158,
-0.0011808461,
0.014697765,
-0.0296719,
-0.015300751,
0.0027919472,
0.02107936,
-0.020011572,
0.0011455149,
-0.0016236634,
-0.0033321215,
-0.016820775,
-0.013856098,
0.020262817,
0.016519284,
-0.027008714,
0.0015899026,
0.023101872,
-0.1549672,
0.020777866,
-0.0017430042,
-0.0015255213,
0.009490737,
0.006858957,
0.019798016,
-0.0064129992,
-0.007870214,
0.009924132,
0.019119658,
0.018604608,
-0.012637566,
-0.036229365,
0.0013441546,
0.0073363204,
-0.027837818,
0.02228533,
0.0063690315,
0.002377395,
0.023905853,
-0.015137442,
0.023755107,
-0.026908217,
0.00046558626,
0.025250006,
-0.025023887,
0.0031436887,
-0.000074882446,
-0.005696954,
-0.014584705,
0.008774691,
0.0491433,
0.009628921,
-0.03243558,
-0.013341049,
-0.019333215,
-0.02400635,
-0.015665054,
0.021870777,
0.0125810355,
0.04876643,
-0.008875189,
-0.00021179071,
-0.01065274,
-0.008090052,
-0.0017492854,
-0.0114944065,
-0.00073763623,
-0.011990613,
0.0058634034,
0.00089976704,
0.009076185,
0.0052321535,
-0.024584211,
0.0048364443,
-0.0100246295,
0.008743286,
0.018717667,
0.018780477,
-0.03127986,
-0.019509085,
0.00059434876,
0.01283228,
0.03615399,
-0.012562193,
-0.002171689,
-0.0015286618,
-0.011274568,
0.016230352,
-0.0105145555,
-0.017561946,
0.017411198,
-0.023302868,
0.047057975,
0.0110044805,
-0.01472289,
-0.013215426,
0.020664807,
0.006538621,
0.00071015646,
0.0012782031,
-0.020928614,
-0.012763187,
0.012976745,
0.018818164,
0.00418321,
-0.0072232606,
-0.014031969,
-0.014371148,
0.02434553,
-0.03768658,
0.024986202,
-0.0019581318,
-0.017750379,
0.02538819,
-0.00069170573,
-0.012241857,
0.021556722,
-0.00016360293,
0.033239562,
0.0044595785,
-0.019973887,
0.010841172,
0.03741021,
0.0008715021,
-0.011148946,
0.00021100558,
0.054419417,
-0.016657468,
-0.003065175,
0.019961324,
0.006032993,
0.022725007,
0.012329792,
0.010596209,
-0.0021622675,
-0.011481844,
0.0023177245,
-0.029370407,
0.05190698,
-0.0053200885,
0.015175128,
0.04120399,
-0.013655104,
-0.03042563,
-0.11064779,
-0.006639119,
0.006632838,
-0.01850411,
0.018315677,
0.01839105,
-0.0147857005,
-0.009233211,
-0.008090052,
0.014446521,
-0.009691732,
0.0047704927,
0.00658887,
-0.018365925,
0.04251046,
0.008711881,
-0.0022266486,
-0.032460704,
-0.016318288,
0.027611699,
-0.00075608696,
-0.00590109,
0.005408024,
-0.01604192,
-0.025237445,
0.0014964712,
-0.009239493,
0.03442041,
-0.0003605742,
-0.006089523,
0.02125523,
0.0070159845,
-0.01597911,
-0.0069594546,
0.013881223,
-0.021870777,
0.004968347,
-0.008743286,
0.025250006,
-0.04077688,
-0.0010795634,
0.0049306606,
0.04449529,
-0.0069971415,
0.021280354,
-0.017938811,
-0.02926991,
0.0014477927,
0.002715004,
-0.017813189,
-0.018064434,
-0.022900878,
-0.010332404,
-0.007750873,
0.016519284,
-0.026958466,
-0.014132467,
-0.0116011845,
-0.009201806,
0.008215674,
-0.00079730665,
-0.011852428,
-0.01690871,
0.030526128,
0.023064185,
-0.03535001,
-0.0071541686,
-0.01489876,
0.0019455696,
-0.03133011,
-0.004170648,
-0.0026569038,
-0.029646775,
0.0070097037,
-0.0073488825,
0.004371643,
-0.019898513,
0.0037560957,
0.004450157,
-0.0005821791,
-0.008272204,
-0.0039288257,
-0.00022003465,
0.0131400535,
0.018378489,
0.0052918238,
0.010093722,
-0.020099508,
0.035274636,
-0.02291344,
0.015087194,
0.02944578,
0.0189061,
-0.00030600716,
0.015589681,
0.00658887,
-0.021468787,
-0.027486078,
0.010753237,
0.0024590492,
-0.007807403,
0.0007529464,
-0.05557514,
0.014446521,
0.010878859,
-0.01185871,
-0.00020727619,
-0.0005743278,
0.005762906,
0.001925156,
0.026958466,
-0.002331857,
-0.024822893,
0.018931225,
0.018428737,
0.0036681602,
-0.022888316,
-0.010420339,
0.0150997555,
0.028264934,
0.015376124,
0.02183309,
0.004962066,
0.02796344,
0.013629979,
0.03753583,
0.008812378,
-0.015878612,
0.004280567,
-0.005963901,
-0.01220417,
-0.005024877,
-0.009314866,
-0.016720278,
0.009095027,
-0.0024543384,
0.0021465647,
-0.0008817089,
0.0022894596,
0.023164684,
0.006054977,
0.043691307,
-0.0063596102,
-0.009296022,
0.012015738,
-0.017122269,
-0.0036650198,
0.007235823,
-0.038993046,
-0.0008573696,
0.017084582,
-0.02205921,
0.0147857005,
0.00054684794,
-0.01953421,
-0.032033592,
-0.005464554,
0.031229611,
0.0015592822,
0.010753237,
-0.0026883092,
-0.031480856,
0.014346024,
-0.015300751,
-0.01816493,
0.011280849,
0.003420057,
0.006450686,
-0.011927802,
0.0265816,
0.027435828,
0.0018372206,
-0.0041549453,
0.0065700267,
-0.016092168,
0.027611699,
0.004921239,
0.01845386,
-0.01713483,
0.029320158,
0.017737815,
0.005408024,
0.018491548,
0.009126433,
-0.011280849,
0.025903242,
0.023755107,
0.0052038883,
-0.019458836,
0.02756145,
-0.007229542,
-0.0027354176,
-0.010527117,
0.018353363,
0.0029772397,
0.038088568,
-0.011908959,
0.020878363,
0.00572836,
0.01134366,
0.019622145,
0.013931472,
-0.010344965,
0.00888147,
-0.006507216,
-0.0064287023,
-0.013215426,
-0.016418787,
0.00091232924,
-0.0016707716,
-0.027084088,
0.028541302,
0.0043779244,
0.01867998,
0.006519778,
0.009522142,
-0.019069409,
-0.023164684,
-0.018039308,
0.0072169797,
-0.00704739,
0.012876247,
-0.0053012455,
0.0060706795,
-0.022649633,
0.00041926317,
0.0006697219,
0.020551747,
0.02154416,
0.014760576,
0.0041235397,
-0.006708211,
0.015866049,
0.010803485,
-0.0015592822,
-0.0012177476,
0.0066139945,
-0.0047987574,
0.014622392,
0.013830974,
-0.0067270542,
0.053464692,
0.00048207413,
-0.013931472,
0.019396026,
-0.0058005922,
-0.00062928733,
-0.011393908,
0.029973391,
-0.02503645,
-0.025174635,
-0.0036587387,
0.009666608,
-0.0072232606,
-0.047007725,
0.006632838,
0.021506473,
0.0003539005,
0.00555877,
0.033892795,
0.0072044176,
0.010344965,
-0.009446769,
0.015426372,
-0.010853735,
-0.032234587,
0.011023324,
0.022750132,
-0.028491054,
-0.0027118633,
-0.019044284,
-0.014145029,
-0.011224319,
-0.022838065,
-0.0050908285,
0.024584211,
0.0090447785,
-0.0046071843,
-0.02796344,
0.022260206,
-0.009986944,
-0.009189244,
-0.0005868899,
-0.008686756,
-0.0078011216,
-0.045625884,
-0.007769716,
-0.012813437,
0.013077242,
-0.024684709
] |
BACKGROUND & AIMS GS-9620, an oral agonist of toll-like receptor 7 (TLR7), is in clinical development for the treatment of chronic hepatitis B (CHB). GS-9620 was previously shown to induce prolonged suppression of serum viral DNA and antigens in the woodchuck and chimpanzee models of CHB. Herein, we investigated the molecular mechanisms that contribute to the antiviral response to GS-9620 using in vitro models of hepatitis B virus (HBV) infection. METHODS Cryopreserved primary human hepatocytes (PHH) and differentiated HepaRG (dHepaRG | [
-0.009091352,
-0.0041269516,
-0.022349855,
-0.017861124,
-0.031836484,
0.006465111,
-0.03175609,
0.025793446,
-0.030416168,
-0.0166284,
-0.00465287,
-0.015100891,
-0.007436552,
-0.010853346,
0.01709737,
0.014926701,
0.024466926,
-0.0038053708,
0.0009530176,
0.014980298,
-0.02060796,
-0.0058186,
0.009037755,
-0.018879464,
-0.0076509393,
0.0056812577,
0.02074195,
-0.039956395,
-0.016615,
0.015636858,
-0.011061034,
-0.0047868616,
-0.019871004,
0.01676239,
0.0023364844,
-0.034355532,
-0.00034000454,
-0.0023482086,
0.013801169,
-0.0035139385,
0.02460092,
0.022524044,
0.009433032,
0.02393096,
-0.007858627,
-0.0020350025,
-0.0013591807,
-0.02590064,
-0.0076643387,
-0.0065689543,
0.004240845,
0.0034804405,
-0.01096054,
-0.003751774,
0.00897746,
0.0072355643,
0.01096054,
0.009620621,
-0.0014831232,
-0.03751774,
-0.0032275307,
-0.011938681,
-0.038268097,
0.0026463408,
0.00081818824,
0.026034633,
-0.027361153,
0.012555044,
-0.011342417,
0.013553284,
0.018799068,
0.038884457,
-0.003634531,
-0.003172259,
0.02724056,
-0.015060693,
-0.026356213,
-0.0077447337,
0.005510418,
0.013271901,
0.029156644,
-0.0051754382,
-0.0040465565,
0.02770953,
0.019871004,
0.020138986,
0.009881905,
0.01595844,
0.010210185,
-0.015368874,
0.0021622947,
0.013519786,
0.015167886,
0.030871741,
-0.01761994,
0.027428148,
-0.0009764662,
0.018839266,
-0.015261681,
-0.01179799,
-0.011054334,
-0.0021204224,
-0.010618861,
-0.0020551013,
-0.020902742,
0.0049108043,
0.000963067,
0.007061375,
0.009479929,
-0.013312099,
-0.038750466,
0.033953555,
-0.008381195,
-0.011141429,
0.030791346,
0.011308919,
0.024627717,
0.0048907055,
-0.0017284959,
-0.02891546,
0.0139887575,
0.0045088283,
0.0199246,
-0.007925623,
0.017713733,
-0.0001759691,
-0.028781466,
-0.009727814,
-0.010397774,
-0.006411514,
0.010451371,
0.023770168,
0.01279623,
0.008394594,
-0.016842786,
0.02009879,
-0.01641401,
-0.002941123,
-0.016119229,
-0.009841708,
0.00074281776,
0.02109033,
-0.0016171151,
0.00083033124,
0.011697495,
0.007604042,
0.032613635,
0.017700335,
-0.004183898,
0.0025475216,
0.0004949327,
-0.027843524,
0.020808946,
0.0134929875,
0.0054099243,
-0.005962641,
-0.0056544594,
0.043600973,
-0.0059525915,
-0.012213364,
0.002127122,
-0.03684778,
0.03256004,
0.009446431,
0.0065019587,
0.02142531,
0.0019194344,
0.010545165,
-0.012735933,
-0.0085285865,
-0.005527167,
0.015529665,
-0.01196548,
0.010404473,
-0.0050079483,
0.011355816,
0.004267643,
-0.0005405737,
0.0249225,
-0.021023335,
-0.020366773,
-0.008374495,
0.029103048,
-0.008434792,
-0.024359733,
0.009218645,
0.014940101,
-0.008722874,
0.015864644,
-0.014886504,
0.01629342,
-0.0062507237,
0.007041276,
-0.02060796,
-0.64058864,
-0.022323055,
0.018008515,
0.011262022,
0.016735593,
0.02240345,
0.0166284,
-0.0062473738,
-0.025458466,
0.015529665,
-0.012501447,
0.011911883,
0.009004258,
-0.01973701,
-0.01394856,
-0.038402088,
-0.0073628565,
0.011389314,
0.024212342,
0.0004748339,
-0.028218701,
-0.013091012,
-0.0042642932,
0.016507806,
0.02438653,
0.0063210693,
0.01926804,
-0.019549422,
-0.005895645,
0.04451212,
0.00021365432,
0.035775844,
0.018638277,
0.01196548,
0.044592515,
0.0042609433,
-0.0043279394,
0.0062373243,
0.027347753,
0.030925337,
-0.031836484,
0.0007281624,
0.013077613,
-0.0010719354,
-0.00481366,
0.029290637,
0.025981035,
0.004431783,
-0.0080261165,
-0.010002498,
-0.0024168794,
0.0020048544,
0.010478169,
0.005674558,
0.019710213,
-0.00897746,
0.008374495,
-0.022483846,
0.0015986912,
0.011583602,
-0.00054811075,
0.018892862,
0.0022845624,
-0.04665599,
-0.019040253,
0.0027116616,
-0.020339975,
-0.0030968885,
0.02292602,
-0.005403225,
0.009446431,
0.03749094,
-0.007416453,
0.00050288846,
-0.0013893289,
0.028084708,
-0.0054501216,
0.003170584,
0.004904105,
0.008622381,
-0.0027166863,
0.0048940554,
-0.0077648326,
0.0059927893,
0.027816726,
-0.028995855,
-0.026436608,
0.0055774143,
0.014832906,
0.0020484016,
0.014497927,
0.022952817,
-0.010056094,
0.003388321,
-0.012079373,
0.028138306,
-0.0029980694,
0.002272838,
-0.00007469003,
-0.0019562822,
-0.017727133,
-0.01925464,
0.008769772,
0.009278941,
0.017646737,
0.0011506557,
-0.049630612,
-0.014497927,
0.044324532,
-0.01843729,
0.01607903,
0.0031136374,
-0.007825129,
0.017164366,
0.015837846,
-0.014698915,
0.01843729,
-0.00481701,
0.010578663,
-0.05051496,
0.021787088,
-0.000511263,
0.011824788,
0.01609243,
0.003925964,
0.02623562,
-0.0026831885,
-0.009051155,
-0.009868505,
-0.014162947,
0.008655879,
-0.011838187,
0.013827967,
-0.018142508,
0.043091804,
-0.0016012036,
0.019683415,
0.0068871854,
0.012970419,
-0.03505229,
-0.039554417,
0.0006285059,
-0.007791631,
0.0153152775,
0.0071149715,
-0.010035995,
-0.01928144,
0.0036914777,
0.0005024697,
-0.015409072,
0.028540282,
-0.010370975,
0.00448203,
0.004783512,
0.0005711406,
-0.011483109,
0.020232782,
-0.03057696,
-0.002472151,
0.0068503376,
0.016909782,
-0.003106938,
0.012059274,
-0.019817406,
-0.011402713,
-0.02358258,
0.0075169476,
0.03282802,
-0.01728496,
-0.02888866,
0.0010250383,
-0.016842786,
-0.01561006,
0.018986657,
0.014873104,
0.00249225,
0.0039326632,
-0.007021177,
-0.008649179,
-0.009667518,
-0.00980821,
-0.00044175464,
-0.0025357972,
-0.0023130358,
0.041430306,
-0.012488048,
0.0075102476,
0.046923973,
0.025994435,
0.028995855,
-0.011389314,
0.027816726,
-0.024775108,
0.02060796,
0.004431783,
-0.0067364443,
0.023676375,
0.006857037,
0.018383693,
0.0215995,
0.018866064,
-0.027079768,
0.015851246,
-0.035561457,
0.01561006,
-0.011389314,
-0.003190683,
-0.013975359,
0.0041872477,
-0.00045557256,
-0.0046026227,
0.010210185,
-0.0057449043,
-0.010444671,
0.006026287,
0.0050045988,
-0.0063713165,
-0.009084653,
0.008407993,
-0.038884457,
-0.0019077101,
-0.02308681,
0.007583943,
-0.011838187,
-0.026664395,
0.024373133,
0.012856526,
0.014538124,
-0.002639641,
0.0038958155,
-0.01594504,
-0.01527508,
0.0018574632,
0.0048739566,
0.017686935,
-0.008488389,
-0.00073779305,
-0.020701753,
0.014913302,
0.011315619,
0.0025726452,
-0.00012959533,
0.03336399,
0.0048404587,
0.011583602,
-0.0057080565,
0.0057549533,
-0.0034670413,
-0.01609243,
0.008997559,
-0.0249091,
0.0144845275,
-0.024949297,
-0.0015986912,
0.020004995,
-0.012930222,
0.0031002383,
0.010605461,
0.046280812,
0.011201725,
0.022885822,
0.026222222,
0.008702776,
-0.018785669,
0.014149548,
0.022055073,
-0.018732073,
-0.000307344,
-0.011898483,
0.007007778,
0.008575483,
-0.003071765,
0.001860813,
-0.029263837,
0.0065488555,
0.0012553369,
0.017311757,
0.005945892,
0.026275817,
-0.019187644,
-0.013204905,
-0.034784306,
-0.0024554022,
0.014162947,
-0.0027954066,
-0.0074968487,
-0.01030398,
-0.017834326,
0.004183898,
0.0062507237,
-0.0044083344,
0.017365355,
0.02789712,
0.006233975,
-0.018356895,
-0.019777209,
0.024118548,
-0.012856526,
-0.026691193,
0.010076193,
-0.0066560493,
-0.003470391,
-0.01062556,
-0.030844942,
0.0086893765,
-0.0026614147,
-0.0072623626,
-0.012072673,
-0.010652359,
-0.006840288,
0.017552944,
0.0018239651,
-0.001344944,
-0.030684153,
0.017820926,
0.015435871,
-0.0332568,
0.01709737,
0.021854084,
-0.020567762,
-0.009493329,
-0.030255377,
-0.010766252,
-0.017177766,
0.017030375,
0.008428092,
-0.005781752,
0.014605121,
0.015730653,
0.010953841,
-0.00061803777,
-0.029692613,
0.00025814382,
-0.0009379435,
-0.005460171,
0.0063210693,
-0.030014193,
-0.007289161,
0.002272838,
0.015261681,
0.014605121,
-0.029290637,
0.0075772437,
-0.0009379435,
0.0026329414,
0.0075169476,
-0.0014387383,
0.013399193,
0.027977515,
-0.0061569293,
0.0037919716,
0.03387316,
-0.009600522,
-0.03215806,
-0.023435188,
-0.0064014643,
-0.006826889,
0.014899903,
0.00045347895,
-0.035936635,
-0.0028155055,
-0.0115032075,
0.0016958354,
0.0045188777,
0.004766763,
0.019348435,
0.014149548,
-0.0046193716,
0.0000012545387,
-0.015824446,
-0.01676239,
0.0077112354,
-0.007818429,
-0.016561402,
0.025002895,
-0.0030282177,
0.013318798,
-0.02557906,
-0.0050045988,
-0.003972861,
-0.011081133,
0.00813331,
-0.005711406,
-0.02923704,
-0.018155906,
-0.053891554,
0.02506989,
-0.010618861,
-0.018986657,
-0.012427752,
-0.012930222,
-0.024426728,
-0.013760972,
0.009821609,
0.0040432066,
-0.015811048,
-0.016842786,
0.0075973426,
0.007396355,
-0.005396525,
0.01046477,
-0.010618861,
0.017780729,
0.036499403,
-0.026985975,
-0.028352693,
0.01792812,
-0.006428263,
0.015878044,
0.007932322,
0.02773633,
-0.0015886418,
-0.015100891,
-0.0071484693,
0.012769431,
0.00018141251,
0.013593482,
-0.007771532,
-0.0035440866,
0.012059274,
0.027870322,
0.022430249,
-0.023488786,
0.004281042,
-0.019536024,
-0.011101232,
-0.012474649,
-0.030362573,
0.0027987566,
0.006190427,
-0.0045088283,
0.001253662,
-0.025230682,
-0.0005841211,
0.017780729,
-0.0014755861,
-0.018464088,
0.00068461505,
0.005580764,
-0.0018105659,
0.003356498,
0.030818144,
0.0028825013,
-0.01641401,
-0.018691875,
-0.0063311188,
0.020018395,
-0.003157185,
-0.015167886,
-0.0002594,
0.012843126,
-0.008434792,
-0.01113473,
-0.035615057,
-0.020688355,
0.01774053,
-0.003668029,
0.0016983477,
-0.023944357,
0.003190683,
-0.033578377,
0.010759552,
-0.001991455,
-0.03684778,
-0.010685856,
-0.004281042,
0.00088602165,
0.005229035,
0.0074968487,
-0.026275817,
-0.002639641,
0.019696813,
-0.009158349,
0.0075169476,
-0.0031739338,
-0.009935502,
-0.023220802,
-0.008649179,
-0.025002895,
-0.034891497,
-0.010478169,
-0.0066326004,
0.026329415,
0.010551864,
0.025096688,
-0.03175609,
0.0103508765,
0.013553284,
0.014966899,
0.0134929875,
-0.018785669,
0.0023482086,
-0.030791346,
0.023127008,
0.008039515,
-0.03186328,
-0.014095951,
0.0033648724,
0.0072489637,
0.012890024,
-0.01079305,
-0.01295032,
0.001792142,
-0.02590064,
-0.028995855,
-0.007671038,
-0.015248282,
-0.01626662,
-0.028218701,
-0.01445773,
0.03604383,
0.008334298,
0.02340839,
-0.0025642705,
0.01278953,
-0.022524044,
0.014417532,
-0.01709737,
0.025525464,
0.00045641002,
-0.009754613,
0.0032174813,
0.0015057343,
0.020179184,
0.0060966327,
0.011255322,
0.021639697,
-0.012099472,
0.0077179354,
0.010612161,
-0.024895702,
-0.017043773,
-0.029317435,
-0.013841366,
-0.024105148,
-0.033122804,
0.0043111905,
-0.03636541,
-0.01394856,
0.01694998,
0.00763754,
0.021961277,
-0.006009538,
-0.007416453,
0.03770533,
-0.01741895,
0.038107306,
-0.014055754,
0.037973315,
0.021532504,
0.0015601686,
-0.033417586,
-0.007436552,
0.0055707144,
0.0046026227,
0.013506386,
0.015261681,
0.013841366,
-0.006743144,
0.013097711,
0.022872422,
-0.033096008,
-0.03306921,
0.0025776697,
0.018531084,
-0.01312451,
-0.013700675,
-0.0054903193,
-0.025418269,
0.027495144,
-0.009727814,
0.010551864,
0.011382614,
-0.008696076,
0.015382274,
0.02092954,
0.007396355,
0.011442911,
-0.031086128,
-0.01428354,
-0.0056578093,
-0.026316015,
-0.0027451597,
-0.009084653,
0.009895304,
0.040974732,
-0.008789871,
-0.03122012,
0.017673535,
-0.0116305,
0.029344233,
0.0011330693,
0.004930903,
0.04065315,
-0.004197297,
-0.017995117,
0.035454266,
0.019482426,
0.007671038,
-0.012970419,
-0.001054349,
-0.00240683,
-0.012816329,
0.007490149,
0.02604803,
0.010190086,
-0.018571282,
0.016347015,
-0.005466871,
-0.016400613,
-0.035963435,
-0.033819564,
0.029531822,
-0.048960652,
-0.0100158965,
-0.011047634,
-0.007992619,
0.030952137,
0.012354056,
0.020018395,
-0.0033615227,
0.025431668,
-0.041296314,
0.01029728,
0.008240504,
0.019000055,
-0.024493726,
-0.0027535341,
-0.010940441,
-0.05874206,
0.015355475,
-0.019656617,
-0.028433088,
-0.048103105,
0.012608641,
0.003071765,
-0.0056410604,
-0.020031793,
0.035802644,
-0.0010937091,
0.019710213,
0.008186907,
-0.009198546,
0.026155226,
0.006297621,
-0.0072958604,
0.022952817,
-0.022805426,
0.0043748366,
0.006692897,
-0.0013265201,
-0.014739113,
-0.018866064,
-0.01594504,
-0.0006218063,
0.0132853,
-0.026691193,
-0.013104411,
-0.018182704,
-0.0045758244,
-0.006920683,
-0.008816669,
0.0020467266,
-0.023863964,
-0.014028955,
-0.0064550615,
0.01477931,
0.00082237547,
-0.011054334,
0.004214046,
-0.00030483166,
-0.012534945,
-0.03872367,
-0.0182631,
-0.010478169,
0.032318853,
-0.0073159593,
-0.00880327,
-0.017727133,
-0.014899903,
-0.034945097,
-0.017713733,
-0.00036554673,
0.0022276158,
0.0023197352,
0.027548742,
-0.0022996366,
0.005359677,
-0.011643899,
-0.009506728,
-0.016146028,
-0.03205087,
0.016306818,
-0.013921762,
0.04330619,
0.024493726,
-0.032506444,
-0.011449611,
0.045798443,
-0.0051184916,
-0.023944357,
0.028191902,
0.0017569693,
0.015837846,
-0.031622097,
0.012367455,
-0.018464088,
-0.0058186,
0.0018624879,
-0.0043245894,
-0.007604042,
0.0037417246,
-0.004699767,
-0.008776472,
-0.017217964,
0.013258502,
-0.012655538,
0.009948901,
-0.016655197,
-0.02673139,
0.009252143,
0.01045807,
0.015248282,
-0.0006079884,
0.010525066,
-0.030201782,
0.013412592,
-0.01875887,
-0.0029846702,
0.011349116,
0.0035407369,
0.0149535,
0.017539544,
-0.0016824362,
-0.013707374,
-0.0018088911,
-0.012193265,
-0.01378777,
0.013734173,
-0.029183442,
-0.0016162777,
-0.033953555,
0.02292602,
0.017365355,
0.00781173,
-0.02904945,
0.005731505,
-0.014765911,
0.011663998,
0.00022736756,
0.00880327,
-0.021210922,
-0.0014387383,
0.00063729915,
0.0034569919,
-0.00498115,
0.0024286038,
0.0018959858,
-0.024051553,
0.013506386,
0.18983977,
-0.0011749418,
0.017177766,
0.010317379,
-0.0014303639,
0.00897076,
0.012749332,
0.014940101,
-0.0037651733,
0.012910123,
0.038482483,
-0.01893306,
0.00041767798,
0.003403395,
-0.006893885,
-0.033685572,
-0.02458752,
-0.016467609,
-0.015087492,
-0.027160164,
0.010766252,
0.0080194175,
-0.0009831658,
-0.013519786,
0.022993015,
-0.008716175,
-0.027977515,
0.004867257,
0.01975041,
0.008582183,
-0.004750014,
0.00647851,
0.0136604775,
0.0146453185,
0.0075705443,
0.0050615454,
-0.00029122308,
-0.013580082,
0.0028724521,
0.01676239,
-0.0024520524,
0.009580423,
-0.03352478,
-0.009868505,
-0.002689888,
0.015904842,
0.002972946,
-0.017727133,
0.0053228294,
0.02260444,
-0.038884457,
0.015583262,
0.028084708,
0.037008572,
0.006093283,
-0.013017316,
0.015811048,
-0.0023197352,
-0.008883665,
0.00614688,
-0.016494406,
0.017164366,
-0.013854765,
0.030844942,
-0.003946062,
0.04000999,
-0.015462669,
-0.0023113608,
-0.008113211,
-0.008836768,
0.015864644,
0.007858627,
-0.038750466,
0.0011163203,
-0.03349798,
-0.013191505,
0.027521944,
0.012568443,
0.023435188,
0.02674479,
-0.0020299777,
-0.011382614,
-0.026450008,
0.01760654,
-0.0028456536,
-0.022055073,
0.04003679,
0.005014648,
-0.017392153,
0.037008572,
0.0061033326,
0.0024889002,
-0.02043377,
-0.014524725,
0.01874547,
-0.017405553,
-0.016588202,
0.007128371,
0.020299777,
-0.008943961,
-0.0182899,
0.09893964,
-0.022014875,
0.014966899,
-0.00681349,
0.025337875,
-0.0004928391,
-0.012588542,
-0.01362698,
0.012233463,
0.0071953665,
-0.039634813,
0.0025994435,
-0.015422471,
-0.0026212172,
0.017914722,
0.033149604,
-0.016521204,
0.02872787,
0.0055606654,
0.008662579,
-0.0011112955,
-0.00930574,
0.023796966,
-0.0110074375,
-0.0057717026,
0.00026128427,
-0.0065019587,
-0.0054568215,
-0.029505024,
-0.009526826,
0.0035072388,
0.0076174415,
0.0011071083,
-0.0007398867,
-0.006213876,
0.0054233233,
-0.0035675352,
-0.043440185,
0.010337478,
0.002091949,
-0.019710213,
0.003721626,
-0.0018842615,
0.025833644,
-0.033176403,
0.0020232783,
0.015583262,
-0.0216129,
-0.002637966,
-0.007275762,
-0.035025492,
-0.0072154654,
0.015569863,
0.021706693,
-0.024681313,
-0.011067733,
-0.0072020665,
0.015020495,
0.0018088911,
-0.030335773,
-0.001004102,
0.03221166,
-0.0038991652,
-0.013707374,
0.019871004,
-0.17000896,
-0.0035474363,
-0.014203145,
-0.012776131,
0.013204905,
0.016373813,
0.0020517514,
-0.0061870776,
-0.00012216295,
0.021545902,
0.04346698,
0.013921762,
-0.04729915,
-0.017164366,
0.0045959232,
-0.031327315,
-0.024694713,
0.0040633054,
0.01759314,
-0.00381877,
0.02042037,
-0.01610583,
-0.023796966,
0.007027877,
0.00947323,
0.022899222,
-0.002825555,
-0.0051385905,
0.002390081,
0.0038489182,
-0.01179129,
0.01941543,
0.02624902,
-0.014511326,
-0.0014429257,
-0.02423914,
0.014846306,
-0.0042642932,
0.0040834043,
0.029799806,
0.013050814,
0.011697495,
-0.006227275,
-0.0017820927,
-0.032908417,
0.0096876165,
0.01644081,
-0.0077782315,
0.017070573,
-0.0021003236,
0.018236302,
-0.024225742,
0.022189064,
0.015502866,
0.013077613,
0.010310679,
0.019670015,
0.007228865,
0.004528927,
0.0017670186,
-0.012481349,
-0.010759552,
0.009948901,
-0.0126622375,
0.019227842,
-0.024011355,
-0.019696813,
0.012193265,
-0.015074092,
0.0060832337,
-0.03454312,
-0.009198546,
0.0216129,
-0.0071953665,
0.021626297,
0.031193322,
-0.015690455,
0.008783171,
0.040492363,
0.012863225,
-0.007128371,
-0.0067799916,
-0.028781466,
0.0064048143,
-0.009620621,
0.029210242,
-0.00465287,
0.019964797,
0.0032878271,
-0.005965991,
0.01808891,
-0.019710213,
0.0067330943,
-0.0093526365,
0.0022209163,
0.019830806,
0.00004982825,
0.0029863452,
-0.0054400726,
0.0033832963,
0.026784986,
0.009875205,
-0.0065388065,
0.013171406,
0.0061703282,
0.0067230454,
-0.026503604,
0.013399193,
0.037839323,
0.01595844,
-0.028674273,
0.003554136,
-0.0033816213,
0.021197524,
0.012555044,
0.018397093,
-0.027977515,
-0.00698098,
0.0012570118,
-0.03636541,
0.057348546,
0.011918582,
-0.016507806,
0.0061033326,
-0.01396196,
-0.02573985,
-0.12134309,
-0.016481008,
0.027267357,
0.002241015,
-0.007985919,
0.030362573,
0.010417873,
-0.0035273377,
-0.012179866,
0.020956337,
-0.015221483,
-0.013935161,
-0.0011272071,
-0.032292057,
0.014873104,
0.014551524,
0.013546584,
-0.0057013566,
0.000011161633,
0.052953612,
0.013419292,
-0.035293475,
-0.0012017401,
-0.0058186,
-0.0009379435,
-0.009969,
-0.02126452,
0.01629342,
0.015435871,
0.014658717,
0.012635439,
-0.006592403,
0.020460568,
0.011536705,
-0.026557202,
-0.026530402,
-0.022792028,
-0.010571963,
0.045744844,
-0.004451882,
-0.0073628565,
0.0148195075,
-0.00022799564,
-0.0060329866,
0.012615341,
-0.021961277,
-0.022162266,
-0.0036981774,
0.047084764,
-0.0083610965,
-0.025351273,
-0.013091012,
-0.019000055,
-0.01775393,
0.023341395,
0.0031337363,
0.012059274,
0.031943675,
-0.022845624,
0.014538124,
0.009526826,
-0.0014739112,
-0.0110141365,
0.016708793,
0.02506989,
0.008086413,
0.0027150116,
-0.01544927,
0.029826604,
-0.020862544,
-0.014069153,
-0.024855504,
-0.01080645,
-0.014136149,
-0.0019462329,
0.0016849486,
-0.0006737282,
-0.010565264,
-0.001229376,
-0.0077380342,
-0.011978879,
-0.020956337,
0.011396014,
-0.0018792369,
0.02142531,
-0.0093459375,
0.003520638,
0.006458411,
0.0067665926,
-0.020983137,
-0.029665813,
0.029424628,
-0.020514164,
-0.022349855,
0.010772951,
0.0024889002,
-0.026758188,
-0.0052223355,
0.020782148,
0.015516265,
-0.023301197,
-0.01926804,
-0.076482594,
0.010612161,
0.015033895,
-0.0059994888,
-0.015033895,
-0.015824446,
0.02425254,
-0.0101766875,
0.0077447337,
-0.013519786,
-0.020286378,
0.007537046,
-0.0095201265,
0.014028955,
-0.03306921,
-0.016722193,
0.03880406,
0.0060564354,
0.024373133,
0.00962732,
0.005416624,
-0.01677579,
-0.011255322,
0.028995855,
-0.012173167,
0.0067196954,
-0.011657298,
0.028138306,
-0.023448588,
-0.010692556,
-0.015851246,
-0.0149535,
-0.002493925,
0.017566342,
0.00030483166,
-0.007041276,
0.02671799,
0.017968317,
0.019120649,
0.029692613,
-0.020299777,
-0.032131266,
0.015529665,
0.019509226,
0.025753248,
0.0014211519,
-0.024466926,
0.025136886,
0.006394765,
-0.011409413,
0.024198944,
0.016454209,
-0.010089592,
-0.014538124,
-0.00432124,
0.005965991,
-0.013533185,
-0.0099757,
-0.015543064,
-0.012843126,
0.008923863,
0.017566342,
0.009553624,
-0.0025642705,
0.01708397,
-0.009540225,
-0.013305399,
-0.012220064,
0.025110088,
-0.0148195075,
-0.035025492,
0.00095050526,
-0.007523647,
0.012883324,
-0.020393573,
-0.0113357175,
-0.0038723669,
-0.00481366,
-0.03055016,
0.00847499,
0.014296939,
-0.0043111905,
-0.018718673,
0.000075841526,
0.007671038,
-0.0014889854,
0.003053341,
0.00864248,
0.014095951,
0.0074968487,
0.001561006,
0.02173349,
-0.0032426047,
0.02126452,
0.0139887575,
0.024694713,
0.010551864,
-0.0059894393,
0.01961642,
0.028459886,
0.00631437,
0.0053295293,
0.016842786,
0.012595242,
-0.009701015,
0.0017217963,
-0.03885766,
-0.038348492,
0.009533526,
-0.008675978,
0.00047190284,
-0.0036747288,
-0.010210185,
0.021559302,
-0.025632657,
0.012702435,
0.010069493,
-0.0182765,
-0.01629342,
0.03585624,
0.00863578,
0.02173349,
0.007932322,
-0.022671435,
0.0106791565,
-0.011597002,
0.043815363,
-0.0029930447,
-0.0010216885,
-0.016869584,
0.0017268211,
0.00061050075,
-0.023783568,
-0.014806109,
-0.007898824,
0.008816669,
-0.012776131,
0.010551864,
-0.0096876165,
0.08414693,
0.028218701,
-0.020232782,
-0.015060693,
-0.017887922,
0.0067230454,
0.011657298,
0.039286435,
-0.0026295916,
-0.036311813,
0.017887922,
-0.027789926,
0.0108399475,
-0.03282802,
-0.034141146,
0.012762732,
0.00051251915,
0.011690796,
-0.0040264577,
0.0077380342,
0.018718673,
-0.0123339575,
0.00018853083,
-0.007825129,
-0.026771588,
0.006646,
0.02792392,
-0.028593877,
-0.004016408,
-0.047245555,
0.013446091,
0.024051553,
-0.012990518,
-0.020822346,
-0.01278283,
-0.019884402,
-0.021800486,
-0.027267357,
0.026932377,
0.014015556,
0.0021857433,
0.018397093,
-0.017244762,
-0.01693658,
0.00814671,
-0.014765911,
-0.044378128,
0.01594504,
0.0021170725
] |
Glutathione (GSH) homeostasis is important during organogenesis. To elucidate the impact of GSH depletion in organogenesis stage embryos on oxidative stress and drug teratogenicity, l-buthionine-S,R-sulfoximine (BSO) was given to timed pregnant CD-1 mice 4 h before exposure to a model teratogen, hydroxyurea (HU) [400 mg/kg (HU-400) or 600 mg/kg (HU-600)]. Treatment with BSO or HU alone or with BSO plus HU-400 did not alter the ratios of glut | [
-0.008525594,
-0.012914874,
-0.0023912,
-0.015109513,
-0.029781466,
0.008320487,
-0.008853764,
0.006129266,
-0.032981128,
-0.02779877,
0.021946397,
0.010180119,
0.0005875447,
0.01090483,
-0.008874275,
0.00456362,
0.033746857,
0.004652499,
-0.003350073,
0.009045197,
-0.027005691,
-0.008060686,
-0.0013921604,
-0.011458617,
0.008805906,
-0.0035791085,
0.010863808,
-0.032188047,
-0.01237476,
-0.00048755525,
0.0020681573,
0.010535638,
-0.019799614,
-0.008047012,
0.007923949,
-0.0011075751,
0.003958556,
-0.008505084,
-0.006693309,
-0.003920953,
-0.0072949547,
0.03259826,
-0.0041704993,
0.029590033,
0.00002391574,
-0.0060369684,
-0.037001215,
-0.01941675,
0.0009759652,
0.021987418,
0.0042046835,
0.027306514,
-0.021795984,
0.0031706048,
-0.005113989,
0.009516942,
-0.0029825906,
0.018938167,
-0.0009554545,
-0.025980158,
0.0070761745,
-0.008525594,
-0.049088825,
0.03270765,
0.004324329,
0.019211642,
-0.012135468,
-0.010296347,
-0.010268999,
0.003914116,
0.028359395,
0.034102377,
-0.01647689,
0.0016921287,
0.019403076,
-0.0030372855,
-0.05934415,
0.0030201934,
0.022712128,
-0.0045465278,
0.026773237,
-0.0059925285,
-0.0013460115,
0.0037807967,
0.009927155,
0.018774083,
0.00041875913,
0.022725802,
0.0027586825,
-0.0060472237,
-0.006382231,
0.0021843843,
0.021358425,
0.01897919,
-0.017434053,
-0.0016605081,
-0.006638614,
0.056390617,
-0.014166023,
-0.025898116,
-0.011472291,
-0.0014212172,
-0.004071364,
-0.016230762,
-0.03694652,
0.006242075,
0.010768092,
0.023833377,
0.0006080553,
-0.018281827,
-0.0054113935,
0.047201846,
-0.012689256,
-0.040310267,
-0.000021832626,
0.0024698242,
0.01908858,
0.017652834,
-0.00399274,
-0.0017861358,
-0.0023638525,
-0.014398477,
0.026034852,
-0.036180787,
0.009065708,
0.008026501,
-0.02595281,
-0.0047550527,
-0.00399274,
-0.0074180188,
0.0011588518,
0.027894486,
0.023874398,
-0.010980035,
-0.022370283,
0.036317527,
-0.014083981,
-0.014125002,
-0.014863385,
-0.03205131,
0.027046712,
0.02841409,
-0.0030988175,
0.010002361,
0.0065121315,
0.02308132,
0.015615443,
0.0182955,
-0.020209828,
0.008614473,
0.0043380028,
-0.008477735,
0.024558086,
-0.0157932,
0.018951843,
0.000091176255,
-0.00086230197,
0.028250003,
-0.029972898,
-0.016449543,
0.021604553,
-0.026909973,
0.010207468,
0.005554968,
-0.00075547566,
0.026868952,
0.017406706,
0.016312804,
0.010316857,
-0.0071924017,
-0.0014357456,
0.017283643,
-0.022383958,
0.016381172,
-0.0041739177,
0.026185265,
0.0012742243,
0.029015735,
-0.0095648,
-0.01742038,
-0.018637344,
0.031203536,
0.036454264,
0.0030988175,
-0.013010589,
0.013817342,
0.0032082077,
-0.0080128275,
0.04047435,
-0.024052156,
-0.005606245,
0.0021091786,
-0.0055071097,
-0.0074863876,
-0.6248365,
-0.0043619317,
0.00095118146,
0.0074385293,
0.0064813658,
0.03713795,
0.0137968315,
-0.005640429,
-0.017502422,
0.02108495,
-0.0033705838,
0.03650896,
0.011328717,
-0.021536184,
0.015437683,
-0.028167961,
0.0025022994,
-0.015711159,
0.03139497,
-0.024435023,
-0.009195609,
-0.02827735,
-0.022643758,
0.017119557,
0.03339134,
0.03872411,
0.020360239,
-0.0019758593,
0.0018733061,
0.03391094,
0.0022014766,
0.024216242,
0.0017220401,
0.025693009,
0.0532183,
-0.017666508,
-0.01430276,
0.029343905,
0.014931754,
0.0537926,
-0.029125124,
-0.011287695,
0.027976528,
-0.0349228,
-0.008142728,
0.020784127,
0.022807844,
-0.005831862,
0.005831862,
0.014972775,
-0.0077120047,
0.0125046605,
-0.0014502739,
0.0037431938,
0.0078077214,
0.0022100226,
0.0060711526,
-0.0260622,
0.0106313545,
-0.005609663,
0.0038867684,
0.03008229,
0.0077256784,
-0.015437683,
-0.005093478,
0.01112361,
-0.029972898,
0.0019519303,
0.021166991,
0.011239837,
0.019074906,
0.032734998,
-0.010166446,
0.004874698,
0.018172437,
0.039872706,
0.0039448817,
0.01669567,
0.00011750894,
0.032270093,
0.0014554017,
-0.0011793624,
-0.013126817,
-0.005431904,
0.03814981,
-0.02874226,
-0.0113013685,
0.007582104,
-0.008915297,
-0.009257141,
0.02261641,
0.020237176,
0.0061395215,
-0.00451918,
-0.0063788127,
0.011568007,
0.012894362,
0.0022014766,
0.022274567,
-0.0293986,
-0.04413892,
-0.006939437,
-0.012559355,
0.033555426,
0.010802276,
0.02025085,
-0.054667722,
-0.009304998,
0.033664815,
-0.015601768,
-0.006953111,
0.02725182,
0.0006781334,
-0.005647266,
0.014945428,
-0.014193371,
-0.017119557,
-0.010405737,
0.013154164,
-0.038286548,
0.0072539337,
0.0058899755,
-0.002792867,
-0.0038696763,
0.006173706,
0.026677521,
-0.0059002307,
-0.00493623,
-0.002599725,
0.00912724,
0.012060263,
-0.0042901444,
0.01847326,
-0.042962976,
0.035688534,
-0.008450388,
0.04047435,
-0.006884742,
0.005561805,
-0.026499761,
-0.028906344,
-0.019717572,
-0.019826964,
-0.004279889,
-0.026376698,
-0.013037937,
-0.01090483,
0.0034286971,
0.003613293,
0.0004990925,
0.004348258,
-0.010576659,
-0.025993831,
0.020483304,
0.009571637,
-0.0147950165,
-0.014453172,
-0.019826964,
0.0022561715,
0.018637344,
0.01162954,
0.03073863,
-0.010207468,
-0.0020151716,
-0.03229744,
-0.011991894,
0.0045225983,
0.007951296,
-0.013195186,
-0.024831561,
-0.01154066,
-0.025036668,
-0.012648235,
0.0115064755,
0.0055242022,
0.002621945,
-0.008805906,
-0.014029285,
-0.020237176,
0.006242075,
0.02362827,
0.0040029953,
-0.009058871,
0.0031671864,
0.011444943,
0.0069496925,
-0.0021553277,
0.01731099,
-0.0013118271,
0.02827735,
0.006676217,
0.02395644,
-0.023177035,
0.0008071796,
0.009373368,
-0.02744325,
-0.008436714,
-0.014125002,
-0.001779299,
0.049307607,
0.023847051,
-0.021317404,
0.013113143,
-0.03139497,
0.03686448,
-0.013776321,
-0.019293686,
-0.0024390582,
0.002266427,
-0.0034218603,
-0.0020596113,
-0.005137918,
0.01028951,
-0.022698455,
-0.001566501,
-0.02358725,
-0.024188895,
-0.015765853,
-0.0077461894,
-0.015779527,
0.02391542,
-0.030219026,
0.0130447745,
-0.00050293823,
-0.025638314,
0.009031523,
0.010351042,
-0.0017220401,
0.01586157,
0.011526986,
-0.005329351,
-0.0022185687,
-0.0050251097,
-0.021850681,
0.028304698,
0.0011195397,
0.009311835,
-0.018227132,
0.0415956,
-0.017721202,
-0.0015348804,
-0.0043345843,
0.027238145,
0.005965181,
0.02180966,
-0.005537876,
0.027867138,
0.0025108454,
-0.01945777,
0.0063651386,
-0.023327447,
-0.0019194551,
-0.03295378,
0.006963366,
0.011779951,
-0.0005144755,
-0.013284065,
0.0258024,
0.02961738,
0.012538845,
0.00871019,
0.01759814,
0.0058216066,
-0.006136103,
0.008853764,
0.022985604,
-0.0076504727,
0.008525594,
-0.0068881605,
-0.008997339,
-0.021672921,
0.0018408309,
-0.009407552,
-0.0019673132,
0.03593466,
0.012108121,
0.02380603,
0.014890733,
0.017584465,
-0.015396662,
-0.015218903,
-0.019430423,
0.017215272,
0.0077325157,
-0.020879842,
0.002398037,
-0.011773114,
0.0077188415,
0.012005568,
0.019143274,
0.0051174075,
0.0040474352,
0.013701115,
0.001222093,
-0.028851649,
-0.033336643,
0.0037637046,
-0.011260347,
-0.008559778,
-0.010029708,
0.004016669,
-0.006802699,
-0.021481488,
0.00014720665,
0.022001091,
0.009838276,
-0.015902592,
-0.011581681,
-0.004225194,
-0.023600923,
0.011260347,
-0.02827735,
-0.00030488227,
-0.027142428,
0.00071659085,
0.0182955,
-0.005934415,
0.009585311,
0.018459586,
-0.0005149028,
-0.015191556,
-0.019225316,
-0.016859755,
-0.041322123,
0.018527955,
0.026198938,
-0.0068197916,
0.032379482,
0.02674589,
0.020811474,
0.014207045,
-0.033363994,
0.024489718,
-0.015465031,
0.0080128275,
-0.017488748,
-0.0069291815,
0.011848319,
-0.0026236542,
-0.003606456,
0.0028407252,
-0.022725802,
-0.0024886257,
0.005008017,
0.00682321,
-0.016326478,
0.0047174497,
0.035962008,
0.019867985,
0.019512465,
0.012210675,
0.019293686,
0.011691071,
-0.0069804583,
-0.0120465895,
0.022671107,
-0.011253511,
0.016408522,
0.0053327694,
-0.025269123,
0.02046963,
0.0065565715,
0.010952688,
0.0060301316,
0.017666508,
0.018281827,
0.004539691,
0.0026578386,
-0.012203838,
-0.029918203,
0.0048302584,
0.0108843185,
-0.037192646,
-0.029918203,
0.024202568,
-0.009229793,
0.022507021,
-0.02152251,
0.026445067,
-0.016887102,
0.0011793624,
-0.0016177776,
-0.011308205,
-0.013181512,
-0.009270814,
-0.029672075,
0.009134077,
-0.016941797,
-0.0062694224,
0.0012776427,
-0.026404046,
0.003589364,
-0.048514526,
-0.0052541452,
0.032652956,
-0.014603583,
-0.027675705,
-0.0010349333,
0.03891554,
0.003705591,
0.009004176,
-0.014644605,
0.010118588,
0.01891082,
-0.010214305,
-0.026827931,
0.007588941,
-0.00351074,
0.019334707,
-0.0011109936,
0.030629238,
-0.030547196,
-0.02907043,
-0.0014408733,
0.018117743,
0.0007610306,
-0.0070283166,
0.0005238762,
-0.0069189263,
-0.0020544836,
0.02674589,
0.025337491,
0.0056609395,
-0.0042388677,
-0.022493348,
-0.0057498193,
-0.010159609,
-0.0139198955,
-0.019977374,
0.005438741,
-0.009557963,
-0.0018425401,
-0.0059856917,
-0.0033569098,
0.020209828,
-0.014986449,
0.01103473,
-0.010604006,
0.0030082287,
0.014726647,
-0.009475921,
0.026827931,
-0.011916689,
0.013516519,
-0.006730912,
-0.034211766,
0.027566316,
0.018404892,
-0.01880143,
0.0004040171,
0.0059139044,
-0.03418442,
-0.01175944,
0.00026001522,
0.0011528695,
0.035305668,
-0.021235362,
-0.026431393,
-0.016723018,
-0.009482758,
-0.014740321,
0.010528801,
-0.006173706,
-0.024202568,
0.0060882447,
-0.0049328115,
0.00007953218,
-0.01658628,
0.031094147,
-0.035661187,
0.0031671864,
0.003914116,
0.0027347535,
0.0064950394,
0.003791052,
-0.02025085,
-0.030629238,
0.0066898908,
-0.021208012,
-0.037548166,
-0.0258024,
-0.0026322003,
0.023218056,
0.028878996,
0.037766945,
-0.01397459,
0.019348381,
0.015711159,
0.022657434,
0.0071445433,
-0.022042112,
0.008477735,
-0.014152349,
0.020032069,
-0.006871068,
0.001965604,
-0.0019194551,
-0.004956741,
0.0019946608,
0.034430545,
-0.0021108878,
-0.012087611,
-0.0054729255,
-0.02275315,
-0.025009321,
0.008812743,
-0.018268153,
-0.009318672,
-0.04039231,
-0.017830594,
0.03984536,
0.010528801,
0.007595778,
-0.012607213,
0.030930063,
-0.016572606,
-0.0018459586,
0.001167398,
0.0020596113,
-0.011752603,
-0.010897992,
0.013092632,
-0.007575267,
-0.011260347,
0.0066898908,
0.014494194,
0.004874698,
-0.014877059,
0.007828232,
0.00018075011,
-0.007342813,
0.00320308,
-0.008525594,
-0.022083133,
-0.025378512,
-0.0029654982,
0.0029125125,
-0.03927106,
-0.0070693376,
0.019321034,
-0.0057429825,
0.01355754,
-0.0008584562,
-0.005640429,
0.0026732215,
-0.009975013,
0.027744073,
-0.00399274,
0.02950799,
0.015123187,
-0.008067523,
-0.015902592,
-0.014357456,
0.003637222,
-0.009722048,
0.025829747,
0.017352011,
-0.0268963,
-0.02674589,
0.013345597,
0.025870768,
-0.016504237,
-0.03147701,
0.0074248556,
0.0034628815,
-0.011725255,
-0.015519726,
-0.012942221,
-0.034676675,
0.014234392,
0.000998185,
0.008764885,
-0.009120403,
-0.0069120894,
0.010330531,
0.0013169547,
-0.00095972756,
0.016011981,
-0.0109663615,
0.008464062,
0.006057479,
-0.029234516,
-0.020332891,
-0.000048819624,
-0.0095101055,
0.027962854,
0.0037124278,
-0.0042730523,
-0.014740321,
-0.00011590654,
-0.0062967697,
-0.016340151,
-0.010761255,
0.040064137,
-0.014986449,
-0.026390372,
0.030328415,
0.011711582,
0.0039448817,
-0.0070419903,
-0.0063070254,
-0.018309174,
-0.040009443,
-0.009120403,
0.0113834115,
0.012142305,
-0.01145178,
-0.007055664,
-0.020496977,
-0.01090483,
-0.027265493,
-0.024188895,
0.008306813,
-0.032543566,
0.014261739,
-0.008204261,
-0.0044063716,
0.021098623,
-0.020715758,
-0.020989234,
-0.012361086,
0.036673043,
-0.006693309,
0.028632868,
0.0076162885,
0.016859755,
-0.011581681,
0.00036064562,
-0.014425824,
-0.027880812,
0.0007516299,
-0.014070307,
-0.038560025,
-0.022507021,
-0.0009913482,
0.0040884563,
0.011985057,
-0.02762101,
0.026773237,
-0.0032509381,
0.02062004,
-0.008696516,
-0.009975013,
0.018924493,
-0.0016553805,
-0.012511497,
0.016326478,
-0.029453294,
-0.0048541874,
0.012087611,
0.0016434159,
-0.0010648447,
-0.030711282,
0.02057902,
-0.00357569,
-0.0016263237,
-0.014589909,
-0.0011930362,
-0.035551794,
-0.022876212,
-0.032133352,
-0.013707952,
-0.013161001,
-0.035141584,
-0.035004843,
-0.018104069,
-0.0003756013,
-0.0020903773,
-0.012135468,
0.019184295,
0.0051721027,
-0.022698455,
-0.03262561,
-0.0024783704,
0.009954503,
0.032817043,
0.010939014,
-0.022821518,
-0.0027962853,
-0.013605398,
-0.021317404,
0.004587549,
0.008272629,
0.015314619,
0.005448996,
0.0073701604,
0.0035004844,
-0.0037192646,
-0.0016271783,
0.021905376,
-0.0052814926,
-0.0125046605,
0.00954429,
-0.0020220084,
0.04504139,
0.0044063716,
-0.033035822,
-0.011697908,
0.013721625,
-0.007958133,
-0.008122218,
0.024845235,
0.0032133353,
0.021057602,
-0.014097654,
0.039517187,
0.0010110042,
-0.0036850802,
-0.0044679036,
-0.015424009,
0.010651865,
0.017885288,
-0.00697704,
-0.0122995535,
-0.010836461,
0.00093665306,
0.0034663,
-0.0120465895,
-0.009530616,
0.014166023,
0.028769607,
0.01134239,
0.008901622,
0.028359395,
0.010583496,
-0.010193794,
-0.0010921921,
-0.006631777,
0.001566501,
0.0022476255,
-0.011274021,
0.024161547,
-0.009202446,
-0.0087307,
-0.014466846,
-0.00225959,
0.014767669,
-0.029097777,
-0.0022989023,
-0.021043928,
-0.018965516,
-0.038587373,
0.0321607,
0.0040747826,
0.0061087557,
-0.011294532,
0.0017690436,
0.0025621222,
0.0025057178,
0.0070351535,
0.004071364,
-0.031340275,
-0.000877685,
-0.017502422,
0.002483498,
0.0032064985,
-0.020032069,
-0.0045055063,
-0.01880143,
0.029261863,
0.1874947,
-0.013181512,
0.023026625,
-0.0058899755,
0.018774083,
-0.019197969,
0.011321879,
0.00440979,
0.0011810716,
0.014726647,
0.017201599,
-0.01963553,
-0.013126817,
-0.00053327694,
0.008833254,
0.0014665115,
-0.018664692,
0.012183327,
-0.016654648,
-0.022301914,
0.016613627,
-0.013236207,
-0.0022561715,
-0.010521964,
0.009776744,
0.0018921075,
-0.008183749,
-0.0050900597,
0.010234815,
0.012983242,
-0.003968811,
-0.012026078,
-0.005954926,
-0.004464485,
0.014986449,
-0.013126817,
-0.019799614,
-0.030164331,
-0.016244436,
-0.007219749,
-0.014767669,
0.03902493,
-0.016053002,
-0.0018305756,
-0.010822787,
0.00976307,
-0.0041704993,
0.0027347535,
-0.0021792566,
0.011062078,
-0.04867861,
0.010911667,
0.027033038,
0.031668447,
0.0052267974,
-0.0017246039,
0.03183253,
-0.009120403,
0.0051413365,
0.02696467,
-0.024339305,
0.012402107,
-0.034977496,
0.02896104,
-0.003380839,
0.02790816,
-0.026308328,
-0.018090393,
-0.000092778646,
-0.017174251,
0.0037876335,
-0.003242392,
-0.026513435,
0.0099681765,
-0.012087611,
-0.009933992,
0.015300945,
0.0027364627,
0.010802276,
0.007848742,
-0.006259167,
0.0049772514,
-0.029425947,
0.020483304,
-0.010986872,
-0.022370283,
0.032106005,
0.009879297,
-0.015765853,
0.027156102,
0.014083981,
0.004556783,
0.007595778,
-0.01564279,
0.0008670023,
-0.017146904,
0.009202446,
0.024257263,
-0.017283643,
-0.003056087,
-0.021754963,
0.059289455,
-0.0053601167,
-0.0015929939,
-0.007506898,
-0.0048781163,
0.011246674,
0.015218903,
-0.018486934,
-0.0024629873,
0.0032133353,
-0.026075874,
-0.011191979,
-0.0029364415,
0.0027364627,
0.026486088,
0.0068505574,
-0.008744374,
0.030492501,
-0.011294532,
0.007835069,
-0.02474952,
0.019471444,
0.016846081,
-0.016244436,
0.00019015082,
-0.042087857,
0.012709767,
-0.030465154,
-0.048979435,
0.0031005268,
-0.02474952,
0.00031342838,
0.017666508,
0.005448996,
-0.026499761,
0.013523356,
0.006389068,
-0.034293808,
0.008176913,
-0.012313227,
-0.0021929306,
-0.01862367,
-0.013407129,
0.016326478,
-0.030219026,
0.010521964,
-0.000096944874,
-0.009933992,
-0.007759863,
-0.028250003,
-0.018938167,
-0.005370372,
-0.030465154,
0.015902592,
-0.033473384,
-0.021358425,
-0.048076965,
0.023477858,
0.014015611,
-0.012552518,
0.021878028,
0.01897919,
-0.018418565,
-0.007821395,
-0.022001091,
-0.17349276,
-0.003753449,
0.023641944,
-0.031805184,
0.022001091,
0.0010050219,
0.01314049,
0.02351888,
-0.024653804,
0.012716603,
0.040747825,
0.007281281,
-0.053272996,
-0.023368469,
-0.0066591245,
0.0040645273,
-0.022876212,
0.03306317,
0.027169775,
-0.0036167116,
0.019977374,
-0.012593539,
0.008306813,
0.0037807967,
0.023382142,
0.024995647,
0.0029176401,
-0.0052541452,
-0.00042730523,
-0.020264523,
-0.030574543,
0.011130447,
0.006665962,
0.015054818,
0.00037901974,
0.007821395,
0.015670137,
-0.00572589,
-0.0067582596,
0.013858363,
0.0074522034,
0.010241652,
-0.010166446,
-0.0055412943,
-0.02874226,
0.03495015,
-0.00241342,
-0.004556783,
0.03981801,
-0.008190586,
0.0147950165,
0.0016921287,
0.011308205,
0.0074863876,
0.011096262,
0.0031859877,
-0.009475921,
0.01564279,
-0.0025740867,
0.014644605,
0.009769907,
-0.02180966,
0.034102377,
-0.0031278743,
0.008334161,
-0.01355754,
-0.001516079,
-0.0076846574,
-0.025228102,
-0.014603583,
-0.014890733,
-0.0049943435,
-0.0030492502,
-0.014507867,
0.010542475,
-0.0042115203,
0.0054797623,
0.018746736,
0.02191905,
0.01081595,
-0.009366531,
0.0034235695,
-0.048514526,
-0.014425824,
-0.011198816,
0.02961738,
0.003064633,
0.0074453666,
-0.0149180805,
0.0098861335,
0.011055241,
-0.01785794,
-0.013851526,
-0.0139198955,
0.026732216,
0.01397459,
0.006871068,
-0.00829314,
-0.017365685,
0.016066676,
0.023108667,
-0.018391218,
-0.011697908,
-0.0012964441,
0.027169775,
-0.0016630719,
-0.022096809,
-0.008450388,
0.046654895,
-0.0077803736,
-0.010617681,
0.0019468026,
0.0059515075,
0.018131416,
-0.006751423,
0.030136984,
-0.0035859456,
0.004115804,
0.005831862,
-0.03560649,
0.05825025,
0.009756233,
-0.02191905,
0.010084404,
-0.0053088404,
-0.020018395,
-0.12776768,
-0.034786064,
0.0023809448,
0.0024886257,
0.013810505,
0.028550826,
0.0061771246,
0.031777836,
0.0098861335,
0.03339134,
-0.022124156,
-0.03927106,
-0.018063046,
-0.022452326,
0.024872582,
0.01680506,
0.013550703,
-0.000026452864,
0.012627725,
0.020278197,
-0.001636579,
-0.023477858,
-0.0053737904,
-0.0043209107,
0.00038072898,
-0.011226163,
-0.02928921,
0.013995101,
0.0028458529,
0.008942644,
0.029972898,
-0.0051721027,
0.020961886,
-0.011554333,
-0.014589909,
-0.015177882,
0.005561805,
-0.028906344,
0.025501575,
0.0041704993,
-0.0036167116,
-0.0057224715,
0.018486934,
0.01154066,
0.022014765,
-0.013017426,
-0.015765853,
0.002568959,
0.023505205,
-0.022671107,
-0.021399446,
-0.014548888,
-0.015068492,
-0.00987246,
0.014767669,
-0.008334161,
0.019211642,
0.02573403,
-0.032817043,
0.013789995,
0.03418442,
-0.0023689803,
-0.013817342,
0.021932723,
0.02351888,
-0.014904407,
-0.029015735,
-0.040556394,
0.02042861,
-0.03229744,
-0.006395905,
0.019444097,
-0.005842117,
-0.015834223,
-0.019115927,
0.016887102,
-0.0139198955,
-0.018897146,
0.013523356,
-0.020155134,
0.0034851015,
-0.0069360184,
0.025392186,
-0.014753995,
0.02014146,
0.0074385293,
0.009933992,
0.022999277,
-0.0014220718,
-0.009065708,
-0.013735299,
0.046299376,
0.0006973621,
-0.017762223,
0.009708375,
0.01891082,
0.0023775264,
0.0047824,
0.041787032,
0.0019348381,
-0.0046148966,
-0.024503391,
-0.057265736,
0.011807298,
0.005066131,
-0.0013981427,
0.0016006854,
-0.016217088,
0.0021382354,
-0.0064266706,
0.006081408,
-0.0024185476,
-0.010993709,
-0.0034013495,
-0.014562562,
-0.01891082,
-0.02228824,
-0.00045465276,
0.014685626,
0.0061395215,
0.020866169,
0.022561716,
-0.016094023,
-0.0105493115,
-0.004642244,
0.0062386566,
-0.010145935,
-0.0058010956,
-0.0040269247,
-0.0070898486,
-0.010542475,
-0.01680506,
0.021372098,
-0.04039231,
-0.006830047,
-0.002027136,
-0.0086349845,
-0.024886256,
0.01575218,
0.01228588,
0.03546975,
0.029425947,
-0.011820972,
-0.017037515,
0.017379358,
-0.0024732426,
-0.004122641,
0.008204261,
-0.025993831,
0.007233423,
-0.005021691,
-0.035415057,
0.03240683,
0.018309174,
0.010597169,
-0.014685626,
-0.024202568,
-0.0057669114,
-0.025747703,
0.0067274934,
-0.03041046,
-0.015068492,
0.0064950394,
0.015519726,
0.009838276,
-0.008922134,
0.022944583,
-0.011438106,
0.0022971928,
-0.02261641,
0.0071924017,
-0.021891702,
-0.03508689,
0.0003629958,
0.011909852,
0.016941797,
0.0012050008,
-0.013892547,
-0.025200753,
0.007629962,
-0.025460554,
0.02860552,
0.007828232,
-0.0148360375,
-0.012415781,
0.02595281,
0.03604405,
0.010275836,
-0.0033705838,
0.015547073,
0.012511497,
0.011827809,
-0.014685626,
0.020045742,
0.011998731,
0.00075419375,
0.025064016,
0.026663847,
0.011335554,
0.0016724727,
-0.009202446,
0.024940953,
0.0039483,
0.008518757,
0.00618738,
-0.001397288,
-0.023997461,
0.026499761,
-0.009995524,
-0.025146058,
0.0014177988,
-0.011827809,
-0.0080128275,
0.015177882,
0.0065121315,
0.0061942167,
-0.016545258,
0.029425947,
-0.0015878662,
-0.009920319,
-0.0010742453,
0.038532678,
0.018828778,
0.037684903,
-0.0057600746,
-0.012326902,
0.034293808,
-0.010863808,
0.041622948,
-0.030547196,
0.02907043,
-0.01362591,
0.028933693,
-0.019567162,
-0.04293563,
-0.026527109,
-0.004269634,
-0.041322123,
0.02025085,
0.010186956,
0.0045602014,
0.091231376,
0.01520523,
-0.019895332,
0.0057122163,
0.0025416114,
0.012511497,
0.008771722,
0.03713795,
0.014234392,
-0.0016570897,
0.05226114,
-0.027169775,
0.03426646,
-0.027456924,
-0.022985604,
0.009202446,
-0.009838276,
0.010583496,
0.00572589,
0.010296347,
0.03194192,
-0.009516942,
0.026882626,
0.026691195,
-0.034430545,
-0.0051413365,
0.024913603,
-0.020018395,
0.0128806885,
-0.021878028,
-0.014015611,
0.010918504,
-0.026075874,
-0.003155222,
0.003032158,
-0.0056506842,
0.0019382566,
-0.00945541,
0.009263977,
0.0081358915,
-0.00923663,
0.010084404,
0.001531462,
-0.01629913,
-0.024147874,
-0.033473384,
-0.028140614,
-0.003117619,
-0.01575218
] |
Productive infection by human immunodeficiency virus type 1 (HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile, reverse transcripts. We have previously identified G1b as the cell cycle stage required for the optimal completion of the reverse transcription process in T lymphocytes. However, the mechanism(s) involved in the blockage of reverse transcription remains undefined. In this study we investigated whether nucleotide levels influence viral reverse transcription in G0 cells. For this purpose the role of the enzyme ribonucleotide reductase was | [
-0.027274707,
-0.023558479,
-0.009424733,
-0.010565092,
-0.0016359122,
-0.0008871323,
0.009344237,
0.016984643,
-0.03536455,
-0.02261936,
0.028280906,
0.013536734,
-0.0055642817,
-0.019547097,
-0.018379906,
0.0022438243,
0.032198377,
-0.008069718,
-0.0010464472,
-0.019573929,
-0.036410995,
0.0056682555,
-0.0073050065,
-0.050309964,
-0.0058694957,
0.019654425,
0.015884532,
-0.027301539,
-0.030937273,
-0.00051190384,
-0.0013893935,
-0.010330312,
-0.0014380264,
-0.009042378,
-0.0138318855,
-0.033674136,
0.0074928305,
-0.015079573,
0.01742737,
0.011953647,
0.022927927,
0.023263326,
-0.008988713,
0.014811253,
0.009122873,
0.011859735,
0.01033702,
-0.0043803207,
-0.005339564,
0.032815512,
0.0017709107,
0.005155094,
-0.013322078,
0.0015092988,
-0.025275724,
-0.01016932,
-0.012758606,
0.028119914,
-0.006510109,
-0.016756572,
-0.030615289,
-0.019869082,
-0.03034697,
0.010779748,
0.013395865,
0.033244822,
0.017400539,
-0.011376759,
0.017923763,
0.011497503,
0.009203369,
0.010511428,
-0.029300522,
0.031339753,
0.01318121,
-0.011765823,
-0.022860847,
-0.00031946826,
-0.00082969514,
0.0073184227,
0.025973355,
-0.009189953,
-0.02425611,
0.04134808,
0.006818677,
0.0039677788,
0.010256524,
0.022565695,
0.026536828,
-0.0089216335,
0.005316086,
0.020258145,
0.037752595,
0.037564773,
-0.012496995,
0.0071976786,
-0.0010623786,
0.030266473,
-0.019922744,
-0.0073452545,
-0.029783497,
-0.013966045,
0.005450246,
-0.010591924,
-0.01558938,
0.017722523,
0.010866952,
0.001324829,
0.009733301,
-0.0028257428,
-0.04864638,
0.011108439,
-0.023773134,
-0.041509073,
0.045319214,
0.008686854,
0.024282942,
0.019667841,
-0.00086784683,
-0.032976504,
0.004286409,
-0.0033070415,
0.02311575,
-0.010645588,
0.039228354,
0.0034126923,
-0.016783403,
-0.012161595,
-0.00976684,
-0.010182736,
0.012765314,
0.008800889,
-0.0037162292,
0.031339753,
-0.008116674,
-0.002411524,
-0.0033975993,
-0.01923853,
-0.0057319817,
-0.021157015,
0.0011445517,
0.02763694,
0.00508466,
0.003766539,
0.036518324,
-0.0060070097,
0.013979461,
-0.011101731,
-0.017883515,
-0.0044339844,
-0.017789602,
-0.027663771,
0.03600852,
-0.015294229,
0.010766332,
0.034344934,
-0.023679223,
0.03074945,
-0.023035254,
-0.02053988,
-0.003934239,
-0.02087528,
0.014381941,
0.013630645,
0.017856682,
0.034640085,
0.0076471143,
0.014328277,
0.0071641384,
-0.014878333,
-0.00045530515,
0.015079573,
-0.026174596,
0.022015639,
0.00047039814,
0.028656553,
-0.018017674,
0.024189029,
-0.011584708,
-0.002644627,
-0.010149197,
0.01756153,
0.019104369,
-0.003944301,
-0.022136383,
-0.006929359,
0.0102229845,
-0.008150213,
-0.018809218,
-0.0015990182,
-0.01776277,
0.0050142263,
0.010531552,
-0.0011915076,
-0.63108814,
-0.014435605,
0.023813382,
-0.0032164836,
0.014663677,
0.015160069,
0.017387122,
0.0045413123,
-0.020955777,
0.037698932,
0.0029095928,
0.02954201,
0.03466692,
-0.020043489,
-0.025222061,
-0.04172373,
-0.016635828,
0.0073989183,
0.011504211,
0.0022471782,
-0.023129167,
-0.020794785,
0.0045681447,
0.031795897,
0.008210585,
0.017735938,
0.043279983,
-0.026831979,
-0.006778429,
0.030320138,
-0.013067174,
0.018540898,
-0.00117893,
-0.0012166626,
0.051839385,
-0.008089842,
-0.011484087,
0.02365239,
-0.0016870607,
0.009505229,
-0.0041052927,
-0.010846828,
-0.00027230266,
0.0017625256,
-0.0082307095,
0.0057621677,
-0.008908217,
0.0115243355,
0.0089820055,
-0.009478397,
0.00799593,
0.0035753613,
-0.012892766,
0.029112699,
0.009163121,
-0.005030996,
0.021519247,
-0.0036357332,
0.015710125,
-0.01361723,
-0.00031842012,
0.018809218,
-0.0079556815,
-0.013241582,
-0.02481958,
-0.00126278,
-0.006520171,
0.011356635,
0.0017591717,
0.006479923,
0.00488342,
0.005292608,
-0.01277873,
0.0007223672,
-0.008720393,
0.03796725,
-0.018057922,
-0.005477078,
-0.00010234933,
0.008317914,
0.004038213,
0.0010799872,
-0.014824669,
-0.002480281,
0.01933244,
-0.019386105,
-0.023357239,
0.021116767,
0.0071708467,
-0.0014464114,
-0.0053965817,
0.006204895,
-0.009418025,
-0.04107976,
-0.021894895,
0.031903222,
0.0037061672,
0.012141471,
-0.024712253,
-0.012114638,
0.0033523205,
0.0038000792,
0.0020643855,
0.0072110947,
0.035981685,
0.0061579393,
-0.042743344,
0.0019738276,
0.0541201,
-0.0436288,
-0.015965028,
-0.0035787153,
-0.011068191,
-0.015253981,
-0.013462946,
-0.024229277,
0.034747414,
0.00023876269,
0.014516101,
-0.018017674,
0.0062484974,
-0.008572818,
0.0141672855,
-0.00513497,
0.0035887773,
0.0019637656,
0.008478906,
-0.018809218,
-0.0121347625,
-0.004044921,
0.0005848533,
-0.018138418,
0.02555746,
-0.0032483465,
0.03155441,
0.016112603,
0.034505926,
0.010779748,
0.0023243201,
-0.028012587,
-0.027408868,
-0.029488346,
-0.0035854233,
0.0002345702,
0.0058359555,
-0.010591924,
-0.00036914935,
-0.009397901,
0.017695691,
-0.002763694,
0.016555332,
-0.014596597,
0.0033992764,
0.03225204,
0.020633793,
-0.018353075,
-0.023477983,
-0.04770726,
0.010196152,
0.0032986565,
-0.0033221345,
0.012523826,
0.0228206,
0.021653408,
0.012651279,
0.0058627874,
0.026952723,
0.0095521845,
-0.007902018,
-0.035310887,
0.007875186,
-0.021666823,
-0.015482052,
0.007465998,
-0.0029297168,
0.020861864,
-0.008975297,
0.0021297883,
-0.009961372,
0.0072379266,
0.000104917235,
-0.019211698,
-0.01358369,
0.0016417818,
0.017642027,
0.011202351,
0.027127132,
-0.015039325,
0.022377871,
0.03496207,
0.0023427673,
0.005041058,
-0.022109551,
0.0017910346,
0.01736029,
-0.0054167057,
0.018473817,
0.018514065,
0.008458782,
0.03724279,
-0.008016054,
-0.021626575,
0.0019134555,
-0.0208082,
0.012637862,
-0.016743155,
0.006610729,
-0.013610521,
0.035928022,
0.008968589,
-0.009625972,
-0.00772761,
0.010954156,
-0.0017138927,
0.0075599104,
0.0128256865,
0.0004523704,
0.023236495,
-0.0032902714,
-0.0041254167,
-0.013308662,
0.02134484,
0.017749354,
-0.0150929885,
-0.017373707,
0.019077538,
-0.008049594,
0.006516817,
-0.018675057,
-0.00752637,
-0.0011328126,
-0.012926307,
-0.0021532665,
0.005674964,
0.006580543,
0.025181813,
0.004209267,
-0.001360046,
0.025611125,
-0.002696614,
-0.018594561,
0.0064229053,
-0.014744173,
-0.016501667,
0.014703925,
0.003847035,
0.03160807,
0.005242298,
-0.017642027,
0.03308383,
-0.00806301,
0.025154982,
-0.040918767,
0.011121855,
0.00042490955,
0.00054292835,
0.0063860114,
0.012966555,
0.044138607,
0.020767951,
0.0068756947,
-0.0018983625,
0.015763788,
-0.0027318308,
-0.01762861,
0.0111889355,
0.01127614,
-0.019090954,
-0.011886567,
0.020311808,
-0.014972244,
-0.017990842,
0.013979461,
-0.031232424,
0.012450038,
0.01870189,
0.008344745,
-0.011182227,
0.018339658,
0.012637862,
-0.014972244,
-0.01351661,
0.01800426,
0.014355109,
-0.0030269828,
-0.0036625653,
-0.03007865,
0.0044708787,
0.0010179383,
0.0029565487,
-0.0069159428,
0.009994912,
0.011926815,
0.0058963276,
-0.014797837,
-0.034371767,
0.027824763,
-0.018353075,
0.010692544,
-0.011490795,
0.0061680013,
-0.00040038343,
-0.014690509,
-0.003836973,
0.029354185,
0.011772531,
0.0060908594,
-0.006929359,
0.0036927513,
-0.02398779,
0.00037376108,
0.008425241,
-0.0035451753,
-0.0057889996,
0.0060237795,
0.014368525,
-0.000064616856,
0.019493433,
0.014247782,
0.0036290253,
-0.0076873624,
-0.027127132,
-0.0021197265,
-0.033647303,
0.020365473,
0.027288124,
-0.014449021,
0.013174502,
-0.019480018,
0.03630367,
0.0046620565,
-0.025906276,
0.032600854,
-0.028334571,
0.0046754726,
-0.00853257,
-0.0073653786,
-0.0012393021,
0.006734827,
0.021800984,
0.0062954533,
-0.016112603,
-0.0037833091,
0.005674964,
0.0064732153,
0.00833133,
0.013570273,
0.022337623,
0.017078554,
-0.0028777297,
0.015267396,
0.0085862335,
0.009109457,
-0.0027804638,
-0.01164508,
0.013187918,
-0.011571291,
0.021331424,
0.0012820655,
-0.040435795,
0.024296358,
0.009062501,
0.012382959,
-0.010122364,
0.006312223,
0.016541915,
0.0058493717,
0.0036726273,
0.022699855,
0.0016132728,
-0.0031745585,
0.007016563,
0.0009349268,
-0.024631757,
0.03469375,
-0.010585216,
-0.020687457,
-0.006624145,
-0.010290064,
0.010679128,
-0.0057755834,
-0.008378286,
-0.008284374,
-0.010256524,
-0.015562548,
-0.027663771,
0.021224096,
-0.008579525,
-0.015414972,
-0.01782985,
-0.00055340957,
-0.011437131,
-0.0009290573,
-0.014703925,
0.0040952307,
-0.03764527,
-0.011068191,
0.015294229,
0.00508466,
0.02351823,
0.008841137,
0.0028978537,
-0.002616118,
-0.0048700045,
-0.010176028,
-0.03198372,
-0.00013908609,
-0.02261936,
0.004138833,
0.013322078,
-0.005222174,
-0.020030072,
-0.008109966,
-0.011202351,
0.018594561,
-0.004008027,
-0.006359179,
-0.013966045,
-0.021331424,
0.027113715,
0.032466695,
0.023558479,
-0.000004228526,
-0.011450548,
-0.020164233,
-0.029488346,
0.005423414,
-0.016850483,
-0.036115844,
-0.017548114,
0.0006271975,
0.020311808,
-0.029434681,
-0.036410995,
0.018782387,
-0.0211436,
-0.011551167,
-0.004054983,
0.0303738,
0.032278873,
0.019855665,
0.0033523205,
0.024658589,
-0.042394526,
-0.012537243,
-0.013523318,
0.044272766,
-0.011893275,
-0.014261197,
0.0036893971,
0.0048498805,
-0.02432319,
-0.025154982,
-0.011155396,
-0.005098076,
0.028710218,
0.02087528,
-0.030937273,
-0.018084755,
0.005480432,
0.011457255,
-0.001249364,
0.020056905,
-0.030803112,
-0.0047224285,
0.005607884,
0.010585216,
-0.010310188,
0.022874262,
-0.03579386,
0.014341693,
0.034613255,
0.0037296452,
-0.011262723,
-0.022632774,
0.0042696386,
-0.012785438,
-0.01026994,
-0.006396073,
-0.025329389,
-0.00020438423,
-0.0014765974,
0.015401556,
0.021385089,
0.043172654,
0.008304497,
-0.0111889355,
0.020580128,
0.014234365,
0.0071507227,
0.0011411976,
0.019802,
-0.016380923,
0.011953647,
0.0074123344,
-0.008284374,
0.013221458,
-0.02790526,
0.014086789,
0.022860847,
-0.009344237,
-0.017293211,
-0.0017306627,
-0.013845301,
-0.027314955,
0.02967617,
-0.013543442,
-0.011631663,
-0.03606218,
-0.011537751,
0.02636242,
-0.013711141,
0.009639389,
0.0047928626,
0.017870098,
-0.00054879783,
0.007787982,
-0.01361723,
0.010129073,
-0.015750373,
-0.00096595124,
-0.0020677394,
0.015441804,
0.013677602,
-0.012577491,
-0.016448004,
0.0079355575,
-0.013254998,
0.02887121,
0.0058158315,
-0.0044474006,
-0.050095305,
-0.011879859,
-0.026952723,
-0.039389346,
-0.004903544,
0.0017642026,
-0.016756572,
-0.011973771,
-0.0023125813,
-0.0056883795,
0.001318121,
-0.018849466,
0.0039778408,
0.027422283,
-0.001328183,
0.0370013,
-0.028066251,
0.029220026,
0.032037385,
0.01733346,
-0.021599744,
-0.019144617,
0.0022371162,
-0.0043467805,
0.023008423,
0.021532664,
0.0057319817,
-0.014006293,
0.021908311,
0.015643043,
0.020660624,
-0.02141192,
0.011202351,
0.015817452,
-0.022941343,
-0.025986772,
-0.013503194,
-0.033754632,
0.011718867,
-0.011343219,
0.025517212,
-0.00096259726,
-0.015039325,
-0.027127132,
0.027824763,
-0.014475853,
0.009330821,
0.0028022649,
-0.018178666,
-0.0032449926,
-0.04596318,
-0.0072446344,
0.0033959225,
-0.029193195,
0.0158577,
-0.006654331,
-0.013570273,
0.009330821,
-0.015240564,
-0.0098674605,
0.011235892,
0.000111625224,
0.04105293,
-0.015830869,
-0.008452074,
0.0128256865,
-0.009230201,
0.016367508,
0.0115243355,
-0.0011235891,
-0.0059969476,
-0.029327353,
-0.006214957,
0.015844284,
0.021572912,
-0.01013578,
0.022096135,
-0.012114638,
-0.014650261,
-0.0323862,
-0.025785532,
0.01970809,
-0.040623616,
0.006838801,
-0.019641008,
0.035847526,
0.022740103,
0.0006217473,
0.0062585594,
-0.0034915113,
0.039791826,
-0.0006053965,
0.018473817,
0.009337529,
0.005674964,
0.0071641384,
-0.011853027,
0.00020857672,
-0.012007311,
0.0089820055,
-0.026442915,
-0.014408773,
-0.013523318,
-0.018514065,
0.0029498409,
-0.0049773324,
-0.0010640557,
0.023813382,
0.0074928305,
0.006456445,
0.018406738,
-0.008613066,
0.02439027,
-0.0004913606,
-0.0044339844,
0.029300522,
-0.01287935,
-0.0062686214,
0.010766332,
-0.0020643855,
0.008016054,
-0.024309773,
-0.018125001,
-0.024403686,
-0.004128771,
-0.008109966,
-0.005309378,
0.012007311,
0.000034037832,
-0.0031477266,
0.0011898306,
-0.0016895762,
-0.001385201,
-0.028951706,
-0.0073184227,
-0.008619773,
0.021089936,
-0.00766053,
-0.009713177,
0.008103258,
-0.024739085,
-0.018983625,
-0.0062652673,
-0.014663677,
0.04727795,
0.0046050386,
-0.0018061276,
-0.014100205,
-0.006577189,
-0.051463738,
0.0048968364,
0.00076387293,
0.0058694957,
-0.001274519,
0.028227242,
-0.018554313,
0.0047995704,
-0.013590397,
0.03158124,
0.0029632568,
-0.011396883,
0.017279794,
0.02007032,
0.007707486,
0.006644269,
-0.024712253,
0.009934541,
0.02284743,
0.0027922029,
0.011302971,
0.009558893,
-0.012376251,
0.014234365,
0.003944301,
0.014395357,
0.013389158,
0.017615195,
0.008807598,
-0.032064214,
-0.014435605,
0.01870189,
0.0020878634,
-0.021586327,
-0.015213733,
-0.021197263,
0.013442822,
-0.002847544,
0.011316387,
-0.03877221,
0.029837161,
-0.009840628,
0.029998153,
0.023813382,
0.0059835315,
0.00057856453,
-0.009371069,
-0.018809218,
-0.0020962483,
0.004306533,
-0.030024985,
-0.008109966,
0.023062086,
-0.0042998246,
-0.0121750105,
0.0043098866,
0.012329294,
-0.020164233,
-0.0028777297,
0.008693561,
-0.011537751,
-0.031205593,
0.015334477,
-0.0016803527,
0.0032248686,
-0.00027041606,
0.012181719,
-0.008472198,
-0.016367508,
0.009243617,
-0.008338038,
-0.008955173,
0.000017949127,
-0.010129073,
-0.004873358,
-0.012631155,
-0.009008837,
0.0010850182,
-0.015844284,
0.0017373707,
0.19404888,
-0.010900492,
0.011182227,
-0.0034915113,
-0.0409456,
0.00097601325,
0.012926307,
-0.011068191,
-0.00772761,
0.00769407,
0.021224096,
0.0074794143,
-0.000019953664,
-0.0035652993,
-0.013000094,
-0.0147173405,
-0.022109551,
-0.006607375,
-0.008143506,
-0.008847846,
0.0044373386,
0.012839102,
-0.004219329,
-0.012295755,
0.047760922,
-0.004024797,
-0.02752961,
0.019158034,
0.007633698,
-0.004122063,
-0.034586422,
0.009303989,
-0.012081099,
-0.00026203104,
0.008103258,
0.012664694,
-0.0070501026,
-0.02967617,
-0.010256524,
-0.0024132011,
-0.00021968683,
0.020258145,
-0.016944395,
-0.027610106,
-0.005413352,
0.021546079,
-0.0063457633,
-0.025235476,
-0.019761752,
0.002901208,
-0.046982795,
-0.0055810516,
0.007613574,
0.019895913,
0.0071775545,
0.014033126,
0.026053851,
0.0033120725,
-0.000038780596,
0.021398503,
-0.006577189,
0.0072781746,
-0.028227242,
0.012839102,
-0.019050706,
0.019573929,
-0.0024769271,
-0.006547003,
0.02736862,
-0.034908406,
0.014462437,
-0.0042126207,
-0.022324206,
-0.007486122,
-0.022485198,
-0.006547003,
0.029327353,
0.031795897,
0.032278873,
0.0027133839,
0.016783403,
0.0014883364,
-0.039228354,
-0.0046654106,
0.005577698,
-0.021103352,
0.0168639,
0.0037698932,
-0.024417102,
0.019560514,
0.013241582,
-0.0072647585,
-0.01254395,
-0.0031125096,
0.0011378436,
-0.008800889,
-0.014422189,
-0.036384165,
0.018420154,
-0.05014897,
-0.019828834,
0.075988166,
0.011356635,
0.0021935143,
0.0021499123,
0.006604021,
-0.0030689077,
0.0009206723,
0.0030303367,
-0.027663771,
0.007808106,
-0.006771721,
0.019694673,
-0.0075397864,
0.0031577887,
-0.0013927474,
0.015280812,
-0.02461834,
0.0150929885,
-0.002647981,
0.0017876807,
-0.009397901,
-0.015227148,
0.017749354,
-0.021492416,
-0.012839102,
-0.010967571,
-0.004031505,
-0.004403799,
-0.018715305,
0.0010011683,
-0.0031544345,
-0.018742139,
0.008358162,
0.019627593,
0.003893991,
0.017373707,
-0.002367922,
-0.018607978,
0.002582578,
-0.00966622,
0.00063139,
0.0030437526,
-0.013026926,
0.009639389,
-0.020996025,
0.023625558,
0.008747226,
-0.02927369,
-0.008418534,
-0.009518645,
-0.031769063,
0.006711349,
-0.0057487516,
0.0058627874,
0.0043970905,
-0.01863481,
-0.010290064,
0.009357653,
0.01953368,
-0.021626575,
0.010216276,
0.024832997,
-0.014878333,
-0.0031309566,
-0.0082910815,
-0.16861217,
0.002587609,
0.017226132,
-0.0020191064,
0.038799044,
0.022874262,
0.0050343503,
0.03415711,
-0.01897021,
0.012852518,
0.022310792,
0.0045446665,
-0.031634904,
-0.0124701625,
-0.010008329,
-0.01043764,
-0.037591603,
0.02329016,
0.03512306,
0.006634207,
0.03332532,
-0.04175056,
-0.01026994,
-0.013536734,
-0.0004808794,
0.010290064,
-0.008438658,
-0.010591924,
-0.016729739,
-0.0112090595,
-0.010913908,
0.018929962,
0.02452443,
-0.022122968,
0.023947543,
0.0072982986,
0.0042226827,
0.010799872,
0.0008208909,
0.009605849,
0.041455407,
0.022699855,
0.008713685,
0.00866673,
-0.017843267,
0.024041453,
0.02087528,
-0.024269525,
0.013100714,
0.005480432,
0.025785532,
-0.017293211,
0.019667841,
0.0073050065,
0.01565646,
0.0046587023,
0.00267649,
0.0042998246,
-0.012114638,
0.008411826,
-0.008338038,
0.0017256316,
0.0469023,
-0.0016711293,
-0.0075666183,
-0.045265548,
-0.0044943565,
-0.00490019,
-0.0082910815,
0.013241582,
-0.026335588,
-0.0017927117,
0.005497202,
-0.019412937,
0.023826798,
0.018406738,
-0.036652483,
0.008076426,
0.0047190743,
-0.003796725,
0.0023813383,
0.01903729,
-0.023142582,
-0.014140453,
-0.032761846,
-0.014690509,
0.010296772,
0.017400539,
0.0086063575,
-0.021103352,
-0.0020224606,
-0.024832997,
0.00776115,
-0.023249911,
0.026885644,
0.018514065,
0.005232236,
-0.0021599743,
-0.0020090444,
0.0095723085,
0.015616212,
-0.011846319,
-0.017964011,
0.002689906,
0.03906736,
-0.018889714,
-0.025074486,
-0.0046922425,
0.049558666,
0.002755309,
-0.018259162,
0.018218914,
-0.005027642,
0.037484277,
-0.012577491,
0.028146747,
-0.005477078,
0.0008523346,
0.0036994591,
-0.01381847,
0.06423576,
0.013402574,
-0.01592478,
0.011490795,
0.0019436416,
-0.009485105,
-0.1402776,
-0.018916545,
0.01013578,
-0.013053758,
0.0017189237,
0.034586422,
-0.0047291364,
0.021250928,
0.0007215287,
0.024175614,
-0.048378058,
-0.0086063575,
-0.019573929,
-0.013489778,
-0.0061914795,
0.019131202,
-0.0055911136,
0.00282742,
-0.03010548,
0.015777204,
-0.007573326,
-0.0046654106,
0.010960864,
-0.011624956,
-0.002720092,
-0.014153869,
-0.02217663,
0.016756572,
0.006134461,
0.0102364,
0.022740103,
-0.020727703,
0.029085865,
-0.01318121,
-0.020928944,
0.0041723726,
-0.031661738,
-0.0023511522,
0.036920805,
-0.018621394,
0.0032902714,
0.033700965,
0.0071641384,
0.00510143,
0.021425337,
-0.018822635,
0.0011252662,
0.010659004,
-0.02461834,
0.0044004447,
-0.030561624,
-0.00536975,
-0.056561813,
-0.020969192,
0.014328277,
-0.030722616,
0.01016932,
0.02499399,
-0.00759345,
-0.027690602,
0.0044507547,
-0.007445874,
-0.0046083927,
-0.0082709575,
0.028763883,
-0.01003516,
-0.0030521378,
-0.01318121,
0.0422872,
-0.028629722,
-0.0017239547,
-0.02141192,
-0.027180795,
-0.0073855026,
-0.012496995,
-0.006292099,
-0.0071775545,
-0.011121855,
0.0154686365,
0.01274519,
-0.022538863,
-0.020311808,
0.010994404,
-0.0011462286,
0.02752961,
-0.0009902677,
0.011115148,
-0.0032349306,
-0.002616118,
0.0010036838,
-0.02425611,
0.039389346,
-0.008988713,
-0.01960076,
-0.0033674135,
0.019023873,
-0.017977426,
-0.0019335796,
0.005715212,
0.031125097,
-0.03201055,
-0.0031795895,
-0.048458554,
0.012047559,
-0.01612602,
-0.013570273,
0.009558893,
-0.0035284052,
0.0040952307,
-0.004031505,
0.002679844,
0.0072043864,
-0.004745906,
0.0033707675,
-0.029166361,
0.0058963276,
-0.022793766,
-0.0042428067,
0.024417102,
-0.013489778,
-0.0016417818,
0.023021838,
-0.009156413,
0.0056883795,
0.0072714663,
0.017172467,
0.011973771,
-0.003971133,
0.004024797,
0.022190047,
-0.008847846,
-0.016139437,
0.008646606,
-0.032466695,
0.003934239,
-0.015482052,
0.006661039,
0.0028341278,
0.01538814,
0.046285164,
0.032439865,
0.04158957,
-0.028307738,
-0.04255552,
-0.0021733902,
-0.006292099,
0.0016392663,
0.013603814,
-0.03783309,
0.018929962,
0.0042629307,
-0.022927927,
0.037484277,
0.029837161,
-0.013737974,
-0.037698932,
-0.02365239,
-0.002377984,
-0.0037799552,
-0.01856773,
-0.014878333,
-0.009733301,
0.024658589,
0.0067079947,
0.011497503,
0.01308059,
-0.009149705,
-0.01080658,
-0.029649338,
-0.0057521057,
0.002647981,
-0.010612048,
-0.030481128,
-0.008780765,
-0.00022932957,
-0.004920314,
-0.00019945804,
0.0016241733,
-0.017293211,
0.01756153,
-0.0046352246,
0.0015772172,
0.0035988393,
0.0037900172,
-0.020056905,
0.0072848825,
0.04378979,
0.010766332,
0.010082116,
0.03201055,
-0.0073050065,
0.00506789,
0.004024797,
0.027851595,
0.025892861,
0.019614177,
0.0027754328,
0.013550149,
-0.016676076,
0.0134159895,
0.0042528687,
0.035606038,
0.010980988,
0.0018614685,
0.006996439,
-0.02127776,
0.00009831405,
0.04663398,
-0.03525722,
-0.048136573,
-0.018876297,
-0.010055284,
0.009458273,
0.008284374,
0.0022924573,
0.0017876807,
-0.009505229,
-0.014220949,
-0.0013466299,
-0.00079447817,
-0.02150583,
0.024913494,
0.012262215,
0.029837161,
-0.0044440464,
-0.008344745,
0.021572912,
0.009672929,
0.021116767,
-0.012087807,
0.02636242,
-0.022002224,
0.004071753,
-0.0023645682,
-0.0015864408,
-0.015240564,
-0.01953368,
-0.011557875,
0.029381018,
0.01003516,
-0.012235383,
0.06681163,
0.004990748,
-0.024940325,
-0.014771005,
-0.03429127,
0.003870513,
0.012067683,
-0.0057554594,
-0.008847846,
-0.035418212,
0.035096228,
-0.012886059,
0.018581146,
-0.04647299,
-0.015710125,
0.014985661,
0.0038134952,
0.015911363,
-0.007016563,
0.0024920201,
0.0062484974,
-0.0061981874,
0.016984643,
0.0070903506,
-0.016877316,
-0.011054776,
0.021760736,
-0.0031359876,
-0.014784421,
-0.019292193,
0.01829941,
-0.009914417,
-0.03743061,
-0.010665712,
0.011289556,
-0.021707071,
-0.019734921,
0.00017713298,
0.03155441,
0.02284743,
-0.00074249116,
-0.0151869,
-0.011953647,
-0.038799044,
-0.021224096,
-0.012577491,
-0.015629629,
-0.017051723,
0.0020794785
] |
BACKGROUND Falciparum malaria or malaria tropica is one of the leading causes of childhood mortality worldwide. Malaria-related deaths occur mainly in sub-Saharan Africa, where an estimated 365 million clinical cases of Plasmodium falciparum malaria occur each year. In Europe, imported malaria cases occur due to returning travellers or immigration mostly from African countries. Children are more at risk than adults. The objective of this study was to identify high risk groups for imported childhood malaria in Europe in order to guide development of strategies for prevention, early recognition and management. METHODS In the period May 2003-January 2005 we | [
0.011535728,
0.007425964,
0.011774443,
-0.046452597,
-0.015884208,
0.026710242,
-0.019187503,
-0.00370653,
-0.014232559,
0.0013693839,
0.0046968735,
-0.00778081,
0.011226044,
0.019406863,
0.017239075,
0.024426324,
0.034942675,
-0.033394255,
-0.00046130008,
-0.0019403637,
-0.016839067,
0.018374583,
0.0034162013,
-0.011264754,
-0.001853265,
0.010406672,
0.010135698,
-0.032103904,
-0.0063711028,
-0.010909908,
0.006954986,
-0.027097348,
-0.0022081113,
-0.004542032,
-0.034762025,
-0.008929221,
0.01563904,
-0.0023339204,
0.00038045162,
0.015626138,
0.0028403827,
0.025174726,
0.008567924,
-0.003783951,
0.012826078,
0.017135847,
0.0180649,
0.015987435,
-0.03153615,
0.019303635,
0.007980814,
0.025987647,
-0.010380865,
-0.0026436043,
-0.010800228,
-0.022194019,
-0.014168042,
-0.0105099,
0.030452257,
-0.034684606,
0.006235616,
0.0006282391,
-0.03403943,
0.00031371633,
-0.004177508,
0.017251978,
-0.0009895371,
0.029368363,
0.0060969032,
0.016477767,
0.033703938,
0.028387697,
0.025045691,
-0.011251851,
0.023290815,
-0.018722977,
-0.015832594,
0.017200364,
-0.015161611,
0.009226002,
0.02157465,
-0.006354973,
-0.033058763,
0.034632992,
0.008284046,
0.0028807062,
0.006671109,
0.03636206,
0.0038613721,
0.008542117,
-0.014155138,
0.01792296,
-0.005045268,
-0.00027742522,
0.017277785,
-0.0132777,
-0.009355037,
0.032723274,
0.018013285,
-0.028000593,
-0.0065259445,
0.0048226826,
-0.015200322,
-0.0009838918,
-0.024529552,
0.0034291048,
-0.0047259065,
-0.0053678555,
0.000050505103,
-0.025277954,
-0.0086453445,
0.0420396,
0.024090832,
-0.021548843,
-0.006819499,
-0.007871134,
0.013664805,
0.01283253,
0.0008258239,
-0.023110166,
0.018748784,
0.0061420654,
0.00940665,
-0.01903266,
-0.0014484178,
-0.00822598,
-0.025368279,
-0.016993908,
0.002109722,
-0.009400199,
-0.02304565,
0.016245505,
0.008013072,
-0.031174853,
-0.005177529,
0.009658269,
-0.02776833,
-0.0094905235,
-0.039175022,
-0.009161484,
0.015200322,
0.012174452,
-0.0007431609,
-0.02518763,
0.0015000318,
0.035200745,
0.0132777,
0.02123916,
0.0070646657,
0.001416159,
0.013522867,
-0.015703559,
0.041239582,
-0.0029290942,
0.013142214,
0.008129205,
0.017742312,
0.01847781,
-0.015316453,
-0.015664848,
-0.0055807633,
0.010980878,
-0.00597432,
0.008496954,
0.0041646045,
0.020697212,
-0.0026581208,
0.009142129,
0.029807083,
-0.0147616025,
0.0024823106,
0.0247102,
-0.005542053,
0.028207049,
-0.0037904028,
-0.0013855132,
0.00036129798,
0.016903583,
-0.018219741,
-0.029290942,
-0.041136354,
0.02371663,
0.020568177,
0.009877629,
-0.02725219,
0.008025976,
0.010561514,
-0.016697127,
0.0066517536,
0.0047549396,
0.0127422055,
0.016348733,
-0.006213035,
-0.0138325505,
-0.65198797,
-0.0071485383,
0.0028484473,
0.01043893,
-0.006722723,
0.0023790826,
0.034374923,
-0.0021403679,
-0.016103568,
0.021639168,
-0.0093808435,
0.021445615,
0.00080606545,
-0.032594237,
-0.0021290772,
-0.01427127,
-0.013935779,
-0.00027137672,
-0.0020193977,
-0.014735796,
-0.015729366,
0.00520011,
0.012019609,
0.028929645,
-0.024761815,
0.011419596,
0.022555316,
-0.041575074,
0.009174388,
0.032826502,
-0.0031274855,
0.031226467,
0.0005887221,
0.024090832,
0.044155773,
-0.03602657,
-0.00063590053,
0.035123326,
0.016426153,
0.017200364,
-0.022297246,
0.0028903838,
0.0372395,
-0.0068388544,
0.0034452341,
0.014890638,
0.009167936,
0.0016629384,
0.013032534,
0.006200131,
0.012180903,
-0.012032513,
-0.026065068,
-0.012142193,
-0.01220671,
0.006538848,
0.020968186,
-0.009755045,
-0.00074719323,
-0.005742057,
-0.03223294,
-0.008503405,
-0.010632483,
-0.002364566,
-0.012703495,
0.016168084,
-0.010174409,
0.021123027,
-0.008748572,
-0.028903838,
0.005125915,
0.016606804,
-0.027665101,
0.008084042,
0.018632652,
0.01180025,
0.013858357,
0.0067162714,
-0.042323478,
-0.00943891,
0.0062678745,
0.00019970181,
-0.017251978,
0.0028178017,
0.03009096,
0.004077506,
-0.010735711,
0.013742226,
0.0024290837,
0.030297415,
-0.00000493017,
-0.00014455951,
0.0068388544,
-0.013432543,
0.006645302,
0.0057775415,
-0.020555275,
-0.024697296,
0.017097136,
-0.0125228455,
-0.011613149,
-0.022064984,
-0.011322821,
-0.02389728,
0.0022419828,
0.022026272,
-0.020916572,
0.004096861,
0.048955876,
-0.032826502,
-0.0025097306,
0.0051807547,
-0.0043162205,
-0.009864725,
0.025148919,
-0.024348903,
-0.004925911,
-0.0061388398,
0.00903245,
-0.02552312,
0.026942506,
0.00932923,
0.011380886,
-0.026323138,
-0.0072517665,
0.020993993,
0.014722892,
-0.019806871,
0.01165186,
-0.03788467,
0.0014492242,
0.0041613784,
0.02578119,
-0.013187376,
0.04539451,
-0.024335999,
0.031690992,
0.0014355143,
0.012019609,
-0.0055452785,
-0.008613085,
-0.016722934,
0.017858442,
0.004990428,
-0.0038258873,
-0.011271207,
-0.0010145376,
-0.008045332,
-0.018981047,
0.007832424,
-0.01072926,
0.004325898,
-0.013716419,
0.0004496063,
-0.0023613402,
0.00088953495,
-0.0031113562,
-0.024219867,
-0.015368068,
-0.016400347,
0.026400559,
0.012387359,
-0.014322883,
0.019303635,
0.013638998,
-0.0032016807,
-0.014632568,
0.00896148,
0.0022726287,
-0.023755342,
-0.00036774972,
-0.01929073,
-0.011490566,
0.019329442,
0.016529381,
0.02393599,
0.0011814766,
-0.004951718,
-0.026942506,
-0.00422267,
0.0026984443,
-0.034426536,
-0.0125486525,
-0.0006963857,
0.017329399,
0.006671109,
0.02345856,
-0.0030403868,
0.009284068,
0.05398824,
0.0018355227,
0.016864873,
-0.034503955,
0.0067872405,
-0.003554914,
-0.0010403446,
0.017122943,
0.04787198,
-0.010413123,
0.040620215,
0.013432543,
-0.00029496592,
0.020374624,
0.013638998,
0.02872319,
-0.04049118,
-0.0071227313,
-0.012929306,
0.03334264,
0.022671448,
-0.0012701881,
0.0006213841,
0.015329356,
-0.030684521,
-0.006106581,
0.006567881,
-0.00591948,
-0.018193934,
-0.0116196005,
0.0076066125,
0.0011040557,
-0.0009419554,
0.023445658,
0.00874212,
0.008903414,
0.013174472,
0.0061710984,
0.010819584,
0.016542286,
-0.0066065914,
-0.01943267,
0.009619558,
-0.00643562,
0.027200576,
0.00059960946,
-0.00096534303,
-0.004283962,
-0.035484623,
0.01482612,
-0.006442072,
0.0023290815,
0.008974384,
0.018710073,
0.020271396,
-0.004603323,
-0.012322841,
0.009916339,
0.0017693923,
-0.0039742775,
0.033678133,
-0.016348733,
0.0061646467,
-0.020013327,
0.005383985,
-0.015484199,
-0.00042823487,
-0.0060549667,
0.0140519105,
0.024787622,
0.025936034,
0.011503469,
-0.017251978,
0.0011169591,
-0.008264691,
0.005416244,
-0.007084021,
-0.0132067315,
-0.0072969287,
-0.0032387783,
-0.0076711304,
-0.035536237,
-0.0030258705,
0.021045607,
-0.014129331,
-0.005480761,
-0.004764617,
-0.009780852,
-0.018039092,
-0.00092905195,
-0.0013209957,
-0.03300715,
-0.026865086,
0.0031129692,
0.028903838,
-0.02193595,
-0.0376266,
-0.009064708,
0.011935737,
-0.020013327,
0.002164562,
-0.0042355736,
-0.004580742,
-0.030478064,
-0.019329442,
-0.022155307,
-0.0025306987,
0.01603905,
0.0043388014,
0.017897153,
-0.010735711,
-0.014322883,
-0.01158089,
-0.022542413,
0.0036678195,
0.0055549564,
0.019600416,
0.008548568,
-0.0012621235,
-0.005583989,
0.022206921,
-0.0056614103,
-0.029781276,
0.00028327212,
0.027355418,
-0.0112454,
0.016993908,
-0.01003247,
0.028903838,
-0.0010451834,
-0.027819945,
-0.017497145,
-0.020335915,
-0.013987393,
-0.014387402,
0.06394974,
0.006074322,
0.0009040514,
0.01943267,
0.025987647,
-0.011103461,
0.015303549,
-0.023665017,
0.018000381,
0.0004213799,
-0.010174409,
0.0033000698,
0.0017274559,
0.0054420508,
0.019806871,
0.024736008,
-0.0023548885,
0.00499688,
-0.0060356115,
0.03902018,
0.026736049,
0.0005250111,
0.015406778,
0.044078354,
0.02861996,
-0.0036129798,
-0.0033903944,
0.012568008,
0.002114561,
0.00172423,
0.0036420126,
-0.017510047,
-0.016710032,
0.02965224,
-0.0033871685,
0.015342261,
-0.012368004,
-0.0061614206,
-0.00536463,
0.011877671,
0.0317168,
0.0061646467,
-0.010129247,
-0.00499688,
0.023071457,
-0.00075687084,
-0.013342218,
0.0037710476,
-0.002316178,
-0.023626307,
0.038375005,
0.010284089,
-0.003142002,
-0.014593857,
0.019871388,
0.0076969373,
-0.002367792,
0.004893652,
0.01323899,
-0.000097633114,
0.0014024491,
-0.037987903,
0.0048807487,
-0.0037226595,
-0.012903499,
-0.0016322926,
-0.009529234,
0.0035097518,
-0.03473622,
-0.018219741,
-0.008271143,
-0.018193934,
-0.013000275,
-0.008322757,
-0.005509794,
0.016413251,
0.019110082,
-0.020348817,
0.009264712,
0.0046226783,
-0.009851822,
-0.0008596956,
-0.0054743094,
-0.02006494,
0.005577537,
0.01722617,
0.03602657,
-0.028181242,
-0.025548927,
0.021548843,
-0.010574417,
-0.0016790678,
-0.0010895391,
0.0158584,
-0.012806723,
0.010484093,
-0.0036258833,
0.026310235,
-0.015019673,
-0.014116428,
0.012342197,
-0.03447815,
-0.028413504,
-0.0057356055,
0.01054861,
0.0154454885,
-0.0009524395,
-0.0050904304,
-0.03551043,
-0.04874942,
0.002727477,
-0.012716399,
0.016877776,
0.01633583,
0.034658797,
0.01482612,
0.006935631,
0.03625883,
0.04126539,
-0.016348733,
-0.0046484857,
0.0054226955,
0.019897195,
0.015135804,
-0.014129331,
0.014839023,
0.027045734,
-0.018903626,
-0.013845454,
-0.027458645,
0.016051952,
0.032284554,
0.012264776,
-0.01283253,
-0.025974743,
-0.009129225,
-0.004451707,
-0.0043162205,
-0.0088518,
-0.010697001,
-0.006467879,
0.015432585,
0.006048515,
-0.026942506,
0.02145852,
-0.027097348,
0.008367919,
-0.020787537,
-0.0040484727,
0.016658418,
-0.014800313,
0.001557291,
-0.01796167,
0.00295974,
-0.013071245,
-0.012368004,
0.0060130307,
-0.018916529,
0.024606973,
0.007335639,
0.033497483,
-0.016568093,
0.015677752,
-0.0005766251,
0.0025565058,
0.0044420296,
0.010897005,
0.010838939,
-0.006203357,
0.014890638,
0.0062678745,
0.004703325,
-0.020839151,
-0.021394001,
0.030632906,
0.019135889,
-0.022671448,
-0.030968398,
0.00011320804,
-0.005400114,
0.0027871558,
0.016348733,
-0.014103524,
0.033265222,
-0.04771714,
-0.011961544,
0.045033213,
-0.0047065513,
0.0034032979,
-0.009890532,
-0.0074195117,
-0.015097094,
0.00033670067,
-0.031768415,
-0.0050130095,
0.008161463,
0.0003215794,
-0.0035194294,
0.0029500625,
0.006471105,
-0.0029549012,
-0.0047259065,
0.012509942,
-0.006338844,
-0.008374371,
0.021394001,
0.0018935885,
0.006613043,
-0.001121798,
-0.017316496,
-0.015961628,
-0.0126325255,
0.007600161,
-0.030452257,
-0.008051784,
0.0006560623,
-0.021910142,
0.019019758,
-0.02234886,
-0.02193595,
-0.01578098,
-0.011038943,
0.0059356093,
-0.018568136,
0.031407118,
0.008542117,
-0.012858337,
-0.033832975,
-0.004200089,
0.0022048855,
0.002675863,
0.03886534,
0.014632568,
-0.02209079,
-0.015097094,
0.003967826,
0.027355418,
-0.011206689,
-0.008942124,
0.038400814,
0.01607776,
-0.0118131535,
-0.00006416466,
0.00038891952,
-0.015174515,
0.041162163,
-0.010690548,
-0.0023355333,
0.021342387,
-0.03225875,
-0.02419406,
0.031510346,
-0.026207006,
0.011103461,
-0.0034968483,
-0.014748699,
0.0067356266,
-0.04454288,
-0.009096967,
0.009045353,
0.0034645894,
0.0044194483,
0.008045332,
0.002238757,
0.01655519,
0.008122752,
-0.014387402,
0.007748551,
-0.0094905235,
0.029936118,
0.0043904157,
0.014864831,
-0.000018863806,
0.020490756,
0.0027194123,
-0.004703325,
-0.0004649292,
-0.019664932,
-0.0062194867,
-0.025690867,
0.028232856,
0.0019355249,
-0.029884504,
-0.008232432,
-0.03883953,
-0.011864767,
-0.0188133,
-0.033161994,
0.003145228,
-0.009174388,
-0.019535897,
-0.005067849,
0.0008092913,
0.009529234,
-0.011851864,
-0.009909887,
-0.0031887772,
0.0055904407,
-0.01375513,
0.005274305,
0.020671405,
0.0152261285,
-0.01010344,
0.0099550495,
-0.02131658,
-0.014258366,
0.009755045,
-0.0091098705,
-0.02389728,
-0.0019355249,
-0.010116343,
0.014555147,
-0.021419808,
-0.03731692,
0.014606761,
0.0132067315,
-0.008393726,
-0.025548927,
-0.00040908123,
0.026387656,
-0.0012927693,
0.0038936308,
0.013509964,
-0.013574481,
0.0022742418,
-0.01972945,
-0.008355016,
0.0036452385,
-0.028000593,
-0.008580827,
0.0045742905,
0.024736008,
-0.0049839765,
-0.00936794,
-0.015303549,
-0.010426027,
-0.0112389475,
-0.004961395,
0.01449063,
0.007974362,
-0.0028419956,
-0.016426153,
-0.017897153,
-0.01040022,
-0.0072582182,
0.008025976,
0.0063517476,
-0.023961797,
-0.04067183,
0.008761476,
-0.025432797,
0.048594575,
-0.0094905235,
-0.005283983,
-0.009419554,
-0.019819774,
-0.04805263,
-0.00002840282,
0.0012226065,
0.020116555,
0.021264967,
0.038736302,
0.01762618,
0.021342387,
-0.0001443579,
0.012735753,
-0.019045565,
0.008258239,
0.007335639,
-0.0029178036,
0.015961628,
-0.020735923,
-0.030400643,
-0.014322883,
0.04291704,
-0.008909866,
-0.01072926,
0.016322926,
-0.0062614228,
0.010787325,
-0.019884292,
0.008929221,
-0.0147616025,
-0.027536066,
0.010342155,
-0.01929073,
-0.020013327,
0.0015556781,
0.012264776,
-0.014193849,
-0.0354072,
0.020452047,
-0.008684055,
-0.0010863133,
-0.032568432,
-0.0019193955,
0.01165186,
-0.031484537,
0.015806787,
-0.006345296,
0.00065364287,
0.009277616,
0.017122943,
0.014645471,
0.010851842,
0.0058581885,
-0.0022694028,
-0.02050366,
0.011148623,
0.0085356645,
0.0085356645,
0.008303402,
0.00022460154,
-0.0067936922,
0.010671194,
-0.028929645,
-0.034787834,
-0.0034710413,
0.035278168,
-0.0060098046,
-0.019910099,
0.000098137156,
0.02087786,
-0.019303635,
-0.011980899,
-0.0001537331,
0.015522909,
-0.01508419,
0.0012322841,
0.00086695387,
-0.00623239,
0.0069291787,
-0.004454933,
-0.0016677772,
-0.02312307,
0.0063162628,
0.17177138,
0.012890595,
0.020606888,
0.0071678935,
0.0011524437,
0.014671278,
0.028413504,
-0.008174366,
-0.003037161,
0.0058936733,
0.0020532692,
0.013509964,
0.010458286,
0.0075549986,
-0.01040022,
-0.0058872215,
-0.041704107,
-0.014813216,
-0.0029710305,
-0.0076969373,
-0.0011097009,
-0.015316453,
-0.014219656,
-0.0075098365,
0.018090706,
0.021677878,
-0.007193701,
0.022865,
0.003114582,
-0.0075291917,
-0.007813069,
0.0012822852,
-0.02193595,
0.016013242,
-0.028774804,
0.002448439,
-0.005800123,
-0.018568136,
0.0049388143,
0.02352308,
-0.011032492,
0.03592334,
-0.002654895,
-0.009129225,
-0.017032618,
0.030452257,
0.0041291197,
-0.024452131,
-0.014929349,
0.014400305,
-0.03584592,
-0.01246478,
-0.024232771,
0.006774337,
-0.023226298,
-0.0030032895,
0.011993802,
0.013742226,
-0.0064517497,
0.01667132,
0.001880685,
0.009148581,
-0.0048775226,
0.027794138,
0.0003955729,
0.032284554,
-0.015290646,
0.01061958,
-0.00047863915,
-0.030374836,
0.008090494,
-0.00892277,
-0.006800144,
0.008477598,
0.0017581017,
-0.03290392,
0.019303635,
0.0014621278,
0.014258366,
0.0018581039,
-0.000052067633,
-0.009129225,
-0.021135932,
0.015380971,
-0.013561578,
-0.042968653,
0.018116513,
0.023006938,
-0.027974786,
-0.01873588,
0.0023371463,
0.017097136,
-0.0035355587,
0.006903372,
0.00094356836,
0.011013136,
0.017381012,
0.019239116,
-0.00009899403,
-0.03816855,
-0.029239329,
0.06271101,
0.010987329,
0.011787347,
-0.013948683,
-0.008258239,
-0.0016806808,
0.022632737,
0.004577516,
0.012368004,
0.01180025,
-0.03628464,
-0.0037549182,
-0.019587511,
-0.0026032808,
0.005767864,
-0.0014476113,
-0.011484114,
0.022529509,
-0.007619516,
-0.010284089,
-0.03401362,
0.018774591,
0.03385878,
-0.018426197,
-0.016942294,
-0.016800355,
-0.00932923,
-0.00064961053,
-0.023574693,
0.005277531,
-0.03625883,
-0.0072066044,
-0.005103334,
-0.007903393,
0.0066775605,
-0.0015339034,
-0.002912965,
0.019264923,
0.020581082,
0.014968059,
-0.022516606,
0.008116301,
0.007103376,
-0.018529424,
-0.004496869,
0.008845349,
0.0070066,
-0.009503427,
-0.008155012,
-0.008522761,
-0.020942379,
-0.00962601,
-0.008787283,
0.033729747,
-0.02385857,
0.010451834,
-0.018761687,
0.020735923,
-0.014619664,
-0.028103821,
0.021006897,
0.013871262,
0.013922876,
0.010638935,
0.008006621,
-0.16103567,
0.0019355249,
-0.0077420995,
-0.005258176,
0.027536066,
0.0013193828,
0.007619516,
-0.0089163175,
0.002730703,
-0.016271312,
0.015522909,
0.009051804,
-0.016568093,
-0.020864958,
0.0093808435,
-0.008600182,
-0.03713627,
0.032207135,
0.032955535,
0.016129375,
0.04660744,
0.0006955792,
0.0070066,
-0.008542117,
0.014439016,
-0.0048775226,
-0.009729238,
0.0034839448,
-0.025419893,
-0.02614249,
-0.042065408,
-0.005248498,
0.021961756,
0.0049484917,
-0.0054678577,
-0.01323899,
-0.011909929,
-0.0007266283,
-0.012335745,
0.0052614016,
0.032465205,
0.015109997,
0.012561556,
-0.006022708,
0.013148665,
0.030994205,
0.004748488,
-0.023832763,
0.028955452,
0.00892277,
0.019561704,
0.014245463,
0.0072775735,
0.016735839,
0.0016822937,
0.008690506,
0.018490713,
-0.0147616025,
0.03130389,
0.0023226298,
-0.03481364,
-0.013509964,
0.0149809625,
-0.0063743284,
0.0017677794,
-0.017097136,
-0.0055485046,
0.024348903,
-0.00896148,
0.016232602,
-0.032594237,
-0.0044452553,
-0.001171799,
-0.015922917,
0.007645323,
0.03016838,
-0.0042517027,
0.0028016723,
-0.010806681,
0.0027339288,
-0.029161908,
0.006390458,
-0.002829092,
0.02171659,
0.0004520257,
0.009264712,
0.01563904,
0.013116406,
-0.015432585,
-0.022413379,
-0.0072711217,
-0.026658628,
0.010567966,
-0.02732961,
0.018426197,
0.011097009,
-0.027432838,
-0.0073227356,
-0.005596893,
0.018374583,
0.014942252,
-0.006048515,
-0.03791048,
-0.008238884,
0.034374923,
-0.01452934,
0.014645471,
0.008309853,
0.042942844,
-0.013213183,
0.006558203,
0.00077783904,
0.004022666,
-0.006819499,
0.0072775735,
0.0045388057,
0.035871726,
-0.0114325,
0.0108841015,
-0.009129225,
0.03868469,
-0.02905868,
0.007342091,
0.027432838,
-0.014955156,
0.012103482,
-0.12253162,
0.035045903,
0.0020468174,
-0.010574417,
-0.0076066125,
0.0033387803,
-0.020026231,
-0.006390458,
0.019574609,
0.006613043,
-0.039587934,
-0.015755173,
-0.00019647593,
-0.020787537,
0.046194527,
-0.0024597296,
0.006025934,
-0.0086453445,
-0.022852097,
0.036439482,
-0.0059065768,
0.00041775077,
-0.004071054,
-0.01556162,
-0.0036516902,
-0.015213225,
-0.01700681,
0.0036000763,
-0.005345274,
0.036052376,
0.001985526,
-0.014413209,
0.0165939,
-0.012019609,
-0.013316411,
0.013780937,
-0.016981004,
-0.0049839765,
0.0073227356,
-0.036671743,
-0.02171659,
0.008142108,
0.017316496,
-0.016180988,
0.032439396,
-0.0060388376,
-0.01740682,
0.0050323647,
0.02389728,
-0.030065153,
-0.012290583,
-0.040284723,
-0.02592313,
-0.025497314,
0.0015742269,
-0.020826247,
-0.01818103,
0.014439016,
0.008258239,
-0.00031149853,
0.004119442,
0.0008338886,
-0.0129873715,
0.012929306,
0.029626433,
-0.01375513,
-0.019639125,
-0.037445955,
0.004719455,
-0.03292973,
-0.024323095,
0.009226002,
-0.0011653473,
-0.009374392,
-0.0365169,
0.020039134,
-0.012638977,
0.01589711,
-0.01482612,
-0.021200448,
-0.009129225,
-0.006513041,
-0.0018548779,
0.0036645937,
0.024645682,
0.03765241,
0.016710032,
-0.016619707,
0.0022339183,
-0.0027129606,
0.0050904304,
0.008761476,
0.004012988,
-0.012251873,
0.015109997,
0.020903667,
-0.00020272606,
-0.022800483,
0.025071498,
0.013871262,
-0.019122986,
-0.025755383,
-0.05708508,
0.011038943,
0.016297119,
-0.0065356223,
0.000887922,
0.014619664,
0.012580912,
0.004603323,
0.011038943,
0.020787537,
0.0069485344,
-0.0028516732,
-0.026813472,
0.023006938,
-0.017419724,
0.011200237,
0.0056710877,
0.039923426,
0.019535897,
0.005587215,
-0.013522867,
0.007548547,
0.012026061,
0.038271777,
0.011419596,
0.0054420508,
0.011955092,
0.037987903,
-0.021329483,
0.018968143,
0.013664805,
-0.03385878,
-0.014709989,
0.010329251,
-0.0058065746,
-0.011755087,
0.0089163175,
0.0056968946,
0.04436223,
0.039897617,
-0.013845454,
0.010129247,
0.016645513,
-0.030632906,
-0.004087183,
0.010871198,
-0.026310235,
0.016658418,
-0.006819499,
0.0065098153,
0.030994205,
0.005532375,
-0.007387253,
-0.007955007,
-0.024400517,
0.013677709,
-0.0018548779,
0.018593943,
0.006800144,
-0.04307188,
0.012271227,
-0.015342261,
-0.010109891,
0.0021726266,
0.0074582226,
-0.028155435,
-0.017264882,
0.028490925,
-0.014387402,
-0.036181413,
-0.0068324027,
0.0059872237,
-0.0031258727,
0.02312307,
-0.008148559,
0.013419639,
-0.01076797,
0.02187143,
-0.00715499,
0.018026188,
0.007574354,
-0.008174366,
-0.04480095,
0.021329483,
0.011019588,
-0.012561556,
-0.0010935715,
0.010116343,
-0.036645938,
0.017561663,
-0.020826247,
0.01154218,
0.006819499,
0.021110125,
-0.024658587,
0.03249101,
0.00726467,
-0.0060710963,
0.027665101,
0.03517494,
0.0005778348,
0.003114582,
0.01106475,
-0.0497817,
-0.0027645747,
-0.0019887518,
-0.011322821,
-0.0376266,
0.0022855322,
0.006022708,
0.0165939,
0.030581292,
-0.002885545,
-0.009013094,
-0.0052678534,
-0.004748488,
0.020116555,
0.023226298,
-0.023174684,
0.016645513,
-0.0036387867,
0.019897195,
-0.01231639,
-0.03267166,
-0.0016097114,
0.00005907383,
0.010045374,
-0.015806787,
0.046633244,
-0.007645323,
-0.0030000636,
0.011393789,
-0.03127808,
-0.0022774676,
0.0026371526,
-0.02776833,
0.048620384,
-0.005613022,
0.008929221,
0.064620726,
-0.02032301,
-0.018193934,
-0.011503469,
-0.01158089,
0.0033968461,
0.0076582264,
0.014103524,
-0.0014048684,
-0.031329695,
0.0014387402,
0.0014274495,
0.019574609,
-0.039846003,
-0.037781443,
0.016310023,
-0.010148602,
-0.0030678068,
-0.020813344,
0.02087786,
0.03292973,
0.008258239,
0.008832445,
0.018452004,
-0.017419724,
-0.005329145,
0.024452131,
-0.0016080985,
-0.005871092,
-0.004345253,
-0.015987435,
-0.008064687,
-0.011161527,
-0.011303465,
0.00050888176,
-0.002808124,
0.0019823,
-0.021742396,
0.012955113,
0.007425964,
-0.006961438,
0.01397449,
-0.025690867,
-0.028310277,
-0.015664848,
0.000017805316,
-0.009206646,
-0.02338114,
-0.029523205
] |
BACKGROUND Long-term exposure to pollution can lead to an increase in the rate of decline of lung function, especially in older individuals and in those with chronic obstructive pulmonary disease (COPD), whereas shorter-term exposure at higher pollution levels has been implicated in causing excess deaths from ischaemic heart disease and exacerbations of COPD. We aimed to assess the effects on respiratory and cardiovascular responses of walking down a busy street with high levels of pollution compared with walking in a traffic-free area with lower pollution levels in older adults. METHODS In this randomised, crossover study, we recruited men and women aged 60 years and older with angiographically proven | [
0.009657141,
0.015265761,
0.021918744,
-0.027230816,
-0.04708662,
0.02465214,
-0.018140985,
0.0031105278,
-0.026663508,
-0.002198321,
-0.032749183,
0.014866066,
0.0068141506,
0.01598779,
-0.011868356,
0.005228265,
0.045436267,
-0.009186532,
0.009109172,
-0.000855798,
-0.025709398,
0.02919061,
-0.0053700926,
-0.0057085436,
-0.004870474,
0.006614303,
0.03437375,
-0.043450687,
-0.008657904,
-0.036256183,
0.013073887,
0.009392827,
-0.03316177,
-0.005411996,
0.0002582705,
-0.0021886511,
-0.01404089,
0.005002631,
0.008225976,
-0.025038943,
0.025877012,
0.0046706265,
-0.009908562,
0.0061211316,
0.0031073045,
0.0135896215,
0.001362669,
-0.010172876,
-0.021660877,
0.018746974,
0.019907378,
0.017109513,
0.010372723,
-0.009889222,
-0.0065014865,
-0.019327175,
0.009470187,
0.019481895,
0.0018373065,
-0.021931637,
-0.014569518,
-0.0020726107,
-0.030944109,
0.0034650955,
-0.026998736,
-0.0008086566,
0.011126986,
0.02656036,
0.0018356949,
-0.00034469643,
0.03540522,
0.010095516,
0.0048189005,
0.019288495,
0.0022789047,
-0.0073879063,
-0.016284337,
0.0012619395,
0.0074846065,
0.014969213,
0.013422008,
-0.036694556,
-0.0013312413,
0.045513626,
0.01797337,
-0.0069366377,
-0.0018405298,
0.012435664,
-0.012377644,
-0.020049205,
-0.01808941,
0.0058181374,
0.01049521,
0.0019340068,
0.004532023,
0.007503947,
0.0015665456,
0.035173137,
-0.0050123013,
-0.01495632,
-0.009676481,
-0.024200872,
-0.023104936,
0.002641531,
-0.036153033,
-0.007329886,
-0.0036423795,
-0.00664009,
0.01881144,
-0.011133432,
-0.0034167455,
0.02617356,
0.0039776075,
-0.015742816,
0.009263893,
-0.01999763,
-0.006066335,
0.022034785,
-0.0061855987,
-0.045436267,
0.04056257,
0.00066682947,
0.023285443,
-0.0128804855,
0.0046480633,
-0.019082202,
-0.029603198,
-0.0036778364,
-0.0040130643,
0.0019501236,
-0.029422691,
0.021441689,
0.0188888,
-0.008380696,
-0.028288074,
0.011288153,
-0.017496316,
-0.012944953,
-0.030428374,
-0.019133775,
-0.008838411,
0.00475121,
-0.01781865,
-0.018360171,
0.002715668,
0.027720764,
0.027462898,
0.007258972,
0.019817123,
0.0039485972,
-0.007955215,
-0.017728396,
0.011378407,
-0.0032700833,
0.0058310307,
0.014247184,
-0.0064724763,
0.024097726,
-0.018063623,
-0.009257446,
0.023285443,
-0.012100436,
0.024665033,
0.01213267,
0.019636616,
0.007916534,
0.008393589,
0.008812625,
0.0012240652,
0.008599884,
-0.0154720545,
0.010462977,
-0.025760971,
0.021390116,
0.050232604,
0.012648405,
-0.0058761574,
-0.00028869082,
0.0017937913,
-0.02735975,
-0.022395799,
0.024484526,
0.011829675,
-0.0026141326,
-0.013344647,
0.0024078386,
0.02091306,
0.016413271,
0.006056665,
-0.016722713,
-0.017032154,
0.015278654,
-0.024084833,
-0.042058203,
-0.6560151,
-0.02136433,
-0.017006367,
-0.007355673,
0.0016140899,
0.021970319,
0.010740185,
0.008632117,
-0.022950215,
0.039118513,
0.015678348,
0.020126564,
0.016078044,
-0.0066723237,
0.00020558896,
-0.008393589,
0.00034328623,
0.0019307835,
0.032181874,
-0.0046867435,
-0.0062790755,
0.022434479,
0.0019581818,
0.00051372056,
0.0033232684,
0.023672244,
0.021583516,
-0.030789388,
0.012699978,
0.025309702,
-0.0010612863,
0.016232764,
0.011784549,
0.022370012,
0.046390377,
-0.010108409,
-0.0062532886,
0.029628985,
0.009792522,
0.031614564,
-0.016194085,
0.007890748,
0.009076939,
-0.021428796,
0.0069495314,
0.010450084,
0.018140985,
0.005966411,
0.025464423,
-0.013795916,
0.0047447635,
0.016787179,
0.0023772167,
0.012699978,
0.039092727,
-0.009147853,
0.01320282,
-0.01419561,
0.00046214706,
0.0021612525,
0.006001868,
0.011849015,
-0.01900484,
0.0001480724,
-0.0019017734,
0.032104515,
-0.020487579,
0.017638143,
-0.016593779,
-0.03411588,
0.009747394,
0.03555994,
0.0129127195,
-0.008715924,
0.029809492,
-0.011165666,
0.01123658,
0.0052927323,
-0.026921375,
0.008574097,
0.021351436,
0.025954371,
-0.03029944,
0.02099042,
0.015781496,
-0.0074652666,
-0.029551625,
0.0000030549377,
0.00072565547,
-0.009180086,
0.0068270443,
0.014827386,
-0.0083420165,
-0.030608881,
-0.025902798,
0.016426165,
-0.009798968,
0.012770892,
-0.007452373,
-0.01037917,
-0.026134878,
-0.013409114,
-0.011423534,
0.0015044962,
0.033058625,
0.009657141,
-0.008361356,
-0.029371118,
0.023453057,
-0.015484949,
0.021776916,
0.00841293,
0.0013868441,
-0.027101882,
-0.010069729,
-0.019559257,
0.014737132,
-0.018321492,
0.003655273,
-0.043476474,
0.017805757,
-0.006211385,
0.016052257,
-0.006704557,
0.007407246,
0.020461792,
0.0015230303,
-0.0036875063,
-0.0047350936,
-0.016194085,
0.012313177,
0.0041967947,
0.029861066,
-0.0012603278,
0.023788285,
-0.00075426267,
0.0024626353,
0.000021656848,
0.016129617,
-0.0047705504,
-0.033754867,
0.011874802,
0.0063532125,
-0.005002631,
-0.006994658,
-0.017547889,
-0.018179664,
0.012429218,
-0.017457636,
-0.0023723817,
-0.017431848,
-0.043966424,
0.0026818227,
0.02656036,
-0.009437953,
0.0055860565,
0.03238817,
-0.014853173,
-0.022653667,
-0.010643484,
0.026947163,
-0.004873697,
-0.003108916,
-0.00923166,
0.0029993223,
-0.0073169926,
-0.007626434,
0.004264485,
0.00068939285,
-0.036307756,
0.01729002,
-0.025593357,
0.0053539756,
0.022034785,
-0.005079991,
-0.0016439058,
-0.011423534,
-0.013731449,
-0.02132565,
-0.013486475,
0.026392747,
-0.014208504,
-0.005002631,
-0.0049897376,
0.024342699,
0.023865644,
0.0047093066,
-0.01686454,
-0.016245658,
0.06276497,
-0.00053104607,
0.03164035,
-0.02991264,
-0.009612014,
0.006140472,
-0.009792522,
-0.005908391,
-0.0028107567,
0.019817123,
0.0064015626,
0.008316229,
-0.028984316,
0.0098440945,
-0.017767075,
0.023388589,
-0.0017728396,
-0.005105778,
-0.007723134,
0.006704557,
0.023298336,
-0.00038921888,
0.023182295,
-0.0049059307,
-0.011629828,
-0.03380644,
0.03341964,
-0.010701505,
-0.0057730107,
0.010450084,
-0.006975318,
0.012235817,
-0.021183822,
0.014750025,
-0.01028247,
-0.034322176,
0.0045255763,
0.0031604895,
0.01747053,
-0.008019682,
-0.0059502944,
-0.0039163637,
-0.009915008,
0.01614251,
0.014247184,
-0.018991947,
0.02888117,
-0.02621224,
-0.012280944,
0.041748762,
0.021854278,
0.008200189,
0.020487579,
0.014595305,
-0.014891853,
-0.011217239,
-0.002912292,
0.040510997,
0.036900852,
0.0029010102,
-0.0019340068,
-0.011965056,
0.0027720765,
-0.009985922,
-0.015600989,
-0.018115198,
-0.008773944,
0.01725134,
0.0062919687,
0.038448054,
0.031846646,
0.034012735,
0.0039485972,
0.017496316,
-0.012390537,
0.0030766826,
-0.002243448,
-0.026483001,
-0.0028784468,
-0.011533127,
-0.003197558,
-0.012255156,
-0.008593437,
-0.005808467,
-0.049510576,
0.020977527,
0.012622618,
0.0060727815,
-0.0044030887,
0.026431426,
0.028442794,
-0.0028800585,
-0.0078004943,
0.019211134,
0.026921375,
-0.020771233,
-0.026947163,
-0.015613882,
0.0011741034,
0.0019082201,
0.016916113,
-0.010469424,
0.00825821,
0.006285522,
0.012906272,
-0.019456109,
0.002710833,
0.022382906,
-0.0023288666,
0.019056413,
-0.010385617,
-0.009960135,
-0.0036133695,
0.009302573,
-0.010043942,
0.008019682,
0.013499368,
0.0060341014,
-0.008967345,
0.0037519734,
0.0048672506,
-0.012558151,
0.003355502,
0.00042266108,
0.001126559,
-0.009779628,
0.010050389,
-0.0059631877,
-0.018824333,
0.03045416,
-0.0094637405,
-0.001278862,
-0.034270603,
-0.006891511,
-0.007355673,
0.060031574,
-0.0009831202,
-0.0032829766,
0.011378407,
-0.017908903,
-0.026766654,
-0.011526681,
-0.04525576,
0.020113671,
0.03143406,
-0.002965477,
-0.025193663,
0.030583095,
-0.0020581055,
0.009354146,
0.011436427,
0.015343121,
-0.017225554,
0.0005564299,
-0.013370434,
-0.001328018,
0.0016954794,
0.023775391,
0.051264074,
0.011997289,
0.012841806,
-0.002056494,
0.014492158,
0.0067174505,
0.004822124,
-0.01316414,
0.026134878,
-0.0024561887,
0.02285996,
-0.007723134,
0.0149434265,
0.023220975,
0.0072202925,
0.015330228,
0.012010182,
0.015433375,
0.004264485,
0.0025915692,
0.00047302584,
0.017844437,
-0.019211134,
0.0003851897,
0.028133353,
0.0068850643,
-0.0046577333,
0.031872433,
0.0030057689,
-0.018914588,
-0.03109883,
0.016245658,
-0.015678348,
0.041568253,
-0.0049220473,
-0.017418955,
0.01117856,
0.0024158969,
-0.02190585,
0.00008954855,
0.0017099844,
-0.011649168,
-0.014543732,
-0.008103489,
0.013654089,
0.002680211,
0.0050735446,
0.0066594305,
-0.015459161,
-0.01606515,
0.011732975,
0.0021274076,
0.009160746,
0.036539838,
-0.027875485,
-0.014298758,
0.0056053963,
-0.012867592,
-0.010753078,
-0.0112946,
-0.011139879,
-0.009476634,
-0.004496566,
-0.0049961843,
-0.021506157,
-0.024278233,
0.014092463,
-0.0013787857,
-0.009096279,
0.00023772167,
0.015497842,
-0.031356696,
0.012139116,
0.02632828,
0.03151142,
-0.0006112268,
-0.013002973,
0.004954281,
-0.019739764,
-0.011952163,
-0.008877091,
0.01106252,
-0.01846332,
0.010856225,
-0.0043321755,
0.02735975,
-0.0044256523,
0.02728239,
-0.032671824,
0.01047587,
0.015858857,
0.020539153,
0.02601884,
0.0031846645,
0.011004499,
0.014285864,
0.0016261775,
-0.027153457,
0.007748921,
0.018128091,
0.011713635,
-0.013305967,
-0.011913482,
-0.010482317,
-0.01224871,
-0.051521942,
-0.0030476726,
-0.013060993,
0.013847489,
0.026766654,
-0.03705557,
-0.017006367,
0.025838332,
0.0013932908,
-0.007981001,
-0.027462898,
-0.0045513627,
-0.017741289,
-0.0066916635,
-0.008967345,
-0.004738317,
0.0720482,
-0.036127247,
-0.0026689295,
-0.010514551,
-0.004983291,
0.00845161,
-0.016658247,
-0.008896432,
-0.023633564,
0.011481554,
-0.02911325,
-0.0391443,
-0.0072331857,
-0.026715081,
0.014969213,
0.017883116,
0.028855382,
-0.0086063305,
0.007955215,
-0.010733738,
-0.0024964805,
-0.00021938891,
0.020500472,
0.0061308015,
-0.008541863,
0.01222937,
0.016619565,
0.011674955,
-0.012384091,
-0.015098147,
-0.0050542047,
0.009257446,
-0.010392063,
-0.008748158,
-0.015613882,
-0.020925954,
-0.012280944,
0.004054968,
-0.018940374,
0.016335912,
-0.020294178,
-0.008806177,
0.009766734,
-0.013834596,
-0.0064273495,
-0.016451951,
0.0007864961,
-0.016310124,
0.013808809,
-0.016542206,
-0.013731449,
0.0020452123,
-0.012409877,
-0.012255156,
0.0088706445,
-0.009902115,
-0.022408692,
-0.00659174,
0.004132328,
0.008148615,
-0.0029300204,
-0.0073879063,
-0.009592674,
-0.014169823,
-0.021970319,
-0.016877433,
0.009109172,
-0.008290443,
-0.010159982,
-0.039505314,
0.005808467,
0.0015141662,
-0.0035231158,
0.042187136,
-0.039427955,
-0.017122407,
-0.012274497,
-0.007413693,
0.003394182,
-0.023259657,
0.041000944,
0.0050509814,
-0.020655192,
-0.021183822,
0.0154720545,
0.005395879,
0.005405549,
0.014144037,
0.016116723,
-0.042212922,
0.008496737,
-0.0053281887,
0.02888117,
-0.0026640943,
-0.018579358,
0.040072624,
-0.00471253,
0.008064808,
0.009644248,
-0.0104371905,
-0.025619144,
0.010585465,
-0.013305967,
-0.01415693,
0.0018244131,
-0.024935795,
0.0015036904,
0.0047576567,
-0.0061082384,
0.011887696,
0.019636616,
-0.021725344,
-0.016013578,
-0.0073750126,
-0.002818815,
0.017083727,
0.024665033,
0.02846858,
-0.004386972,
0.0067174505,
0.0006906016,
-0.005228265,
0.00080462743,
0.021003315,
-0.015626775,
0.033677507,
-0.005154128,
-0.006891511,
0.013795916,
-0.021067781,
0.0031250326,
-0.010211556,
-0.021093568,
-0.030557308,
-0.0017180428,
-0.009715161,
0.02895853,
0.011803889,
-0.025271023,
-0.006704557,
-0.013460687,
-0.0038970239,
-0.0062565124,
-0.012558151,
0.009076939,
-0.023285443,
-0.003600476,
-0.013744342,
0.0016713042,
0.023143616,
0.0047641033,
0.0014013491,
0.0018453649,
0.021248288,
-0.040614143,
0.03323913,
0.0072202925,
0.023594884,
0.007600647,
0.026947163,
-0.030789388,
-0.010643484,
-0.018708292,
-0.010695058,
-0.049845804,
-0.018282812,
-0.023298336,
0.008000341,
0.011713635,
-0.003448979,
0.039814755,
-0.012435664,
-0.0105532305,
-0.013422008,
-0.008554757,
0.011404194,
-0.019971844,
0.01629723,
0.04296074,
-0.024020365,
0.01980423,
-0.015201294,
0.011816782,
0.008148615,
0.0048640273,
-0.026844015,
-0.013093227,
-0.002627026,
-0.026070412,
-0.026740868,
-0.029783705,
-0.007684454,
-0.02159641,
0.03143406,
0.0021950977,
0.008612777,
0.004167785,
0.016090937,
-0.004599713,
-0.0025673942,
-0.021338543,
-0.0048672506,
0.00568598,
0.015742816,
0.0049027074,
-0.023414377,
0.011881249,
0.040433638,
0.02728239,
-0.020938847,
-0.025361277,
-0.0015463997,
-0.055802543,
-0.023491737,
-0.00923166,
0.011126986,
0.019623723,
-0.00850963,
-0.01651642,
0.033393852,
0.0049607274,
0.023981685,
-0.02449742,
-0.019056413,
0.0015963615,
-0.017496316,
0.015446268,
0.0050123013,
-0.020964634,
-0.0013304355,
0.02854594,
-0.0040872013,
0.0058793807,
0.028520154,
-0.012996526,
-0.0054925797,
-0.03808704,
0.003861567,
-0.0043031652,
-0.017728396,
-0.030118933,
-0.026031733,
-0.0019485119,
0.013860382,
-0.023388589,
-0.006285522,
0.012048863,
0.0028010865,
-0.0053894324,
-0.009392827,
-0.009715161,
-0.046828754,
-0.0004899484,
-0.046338804,
0.008135722,
0.026947163,
0.0005483715,
0.022821281,
0.000772394,
0.009031812,
-0.024961581,
-0.014324544,
0.011526681,
-0.013189927,
0.008761051,
-0.007890748,
-0.006262959,
0.0062951925,
0.0071816123,
-0.010817545,
0.0021290192,
-0.040072624,
-0.0083420165,
-0.00761354,
0.016967686,
-0.004312835,
-0.007826281,
-0.0019469003,
0.0006116297,
-0.022434479,
-0.02839122,
-0.015562308,
0.0078971945,
-0.03594674,
0.01972687,
0.008696584,
-0.0068205977,
-0.005972858,
-0.005031641,
-0.01957215,
0.012255156,
0.007710241,
0.18566465,
-0.017457636,
-0.011488001,
0.0031395378,
0.0032636365,
0.013770129,
0.010746632,
0.0046222764,
-0.032104515,
0.0069366377,
0.00475121,
-0.0056795334,
-0.007542627,
0.01127526,
0.00033281033,
-0.0039163637,
-0.035508364,
-0.009186532,
-0.0039969473,
-0.009064046,
-0.0038293335,
-0.00852897,
0.017109513,
-0.0037326333,
0.029809492,
0.017444741,
-0.019365855,
-0.007503947,
0.022937322,
0.002759183,
0.0038712372,
-0.00069624244,
0.0047060833,
0.0052057016,
0.032259233,
0.0014851561,
0.013215713,
-0.02255052,
0.010127749,
0.0053314124,
0.0011555691,
0.004029181,
-0.020487579,
-0.004776997,
0.008064808,
0.02815914,
-0.00048712798,
-0.013344647,
-0.021570623,
-0.012474344,
-0.0403047,
-0.0017389945,
0.008986685,
0.025399957,
0.004628723,
-0.0044256523,
0.019185347,
-0.00060034794,
-0.002986429,
0.0077553676,
-0.007123592,
0.012042416,
-0.009238106,
0.0070849117,
-0.017315809,
0.022112144,
-0.0321303,
-0.0015697689,
-0.028674874,
-0.010907799,
0.0041645616,
-0.018979054,
-0.021196716,
0.005721437,
-0.012964292,
-0.016490633,
0.025541784,
0.01846332,
0.0317435,
0.023491737,
-0.0072138454,
0.0065981867,
-0.04234186,
-0.0041097645,
-0.023788285,
-0.027694978,
0.0059857513,
0.008039022,
-0.033858012,
0.020049205,
0.01777997,
-0.018037837,
-0.030196294,
0.008864198,
0.03648826,
0.002056494,
-0.0066916635,
0.0019098318,
-0.019481895,
0.0052057016,
-0.0066594305,
0.0650342,
0.003374842,
0.012016629,
0.0067561306,
0.015162614,
0.0032684717,
0.016542206,
-0.017199768,
-0.001977522,
-0.0033974054,
-0.031614564,
-0.008670798,
-0.020281285,
0.005653747,
0.01781865,
0.031124616,
-0.005076768,
0.004254815,
-0.016529312,
-0.002061329,
-0.012841806,
0.010649931,
0.008213082,
0.01606515,
-0.0019404535,
-0.028520154,
-0.004812454,
-0.016645351,
-0.030351015,
0.014363225,
-0.02774655,
-0.009895668,
-0.008367803,
0.0029348554,
0.006414456,
-0.002041989,
-0.024536101,
0.020577833,
0.013512261,
0.0039389273,
-0.024922902,
0.008567651,
0.014569518,
0.012093989,
0.01766393,
-0.0015560697,
-0.0029445253,
-0.008425823,
0.020448899,
-0.01984291,
-0.0073750126,
0.017651036,
-0.021183822,
0.009250999,
-0.016838754,
0.010579018,
-0.02209925,
-0.0044546626,
0.0010491987,
-0.016890327,
0.0024803637,
0.016013578,
0.006224279,
-0.008026129,
-0.0011499282,
-0.1614251,
0.0052121487,
0.029628985,
-0.0028671653,
-0.0016398766,
0.009354146,
0.020074992,
-0.013447794,
0.0050832145,
-0.014144037,
0.040201556,
0.0033780653,
-0.009225213,
-0.008922218,
0.021802705,
-0.019868698,
0.0043321755,
0.027411323,
0.012416324,
-0.012867592,
0.012016629,
-0.02888117,
0.02484554,
-0.010952925,
0.000046662954,
0.009147853,
-0.009128512,
0.020500472,
-0.005421666,
-0.01211333,
-0.029809492,
0.005376539,
0.038241763,
0.0013570281,
-0.012609725,
-0.0053507523,
-0.005921284,
-0.039660033,
0.0001040536,
0.022614988,
0.040717293,
0.041671403,
-0.0002159641,
-0.004206465,
-0.021647984,
0.010450084,
0.003703623,
-0.0068850643,
0.014608199,
0.006749684,
0.021106461,
-0.010353384,
0.0058052437,
0.015239974,
-0.015381801,
-0.0018518115,
-0.0057730107,
0.006150142,
0.007922982,
-0.008819072,
-0.010991606,
-0.013641195,
-0.004983291,
0.006017985,
0.025271023,
-0.029293757,
-0.016039364,
0.021183822,
-0.008000341,
0.016245658,
-0.024007471,
-0.019559257,
0.0060534417,
-0.0011966667,
0.02712767,
-0.0021129025,
-0.017586568,
-0.010527444,
-0.012158456,
0.012654851,
0.0022934098,
0.014389011,
-0.028030206,
0.013834596,
-0.024252446,
0.007200952,
-0.0028026982,
-0.00080704497,
-0.005347529,
-0.0154720545,
0.013615408,
-0.016645351,
-0.012480791,
-0.007284759,
-0.0206423,
0.018734079,
0.0188888,
0.0049607274,
-0.00064668356,
-0.0018292482,
0.009321913,
-0.018643826,
-0.02774655,
-0.004216135,
0.03189822,
0.0059986445,
-0.0012917554,
0.0049768444,
0.038989577,
-0.019082202,
-0.006050218,
-0.00035738834,
-0.000058775677,
0.018373065,
-0.013783022,
0.004357962,
0.0079294285,
-0.015239974,
-0.0013127072,
-0.026134878,
0.03125355,
-0.010037496,
-0.0033683954,
0.033832226,
-0.0051863617,
0.007961662,
-0.1180002,
-0.017173981,
0.014324544,
0.017161088,
-0.008864198,
0.018540679,
-0.009573334,
0.008567651,
0.016929006,
0.0121713495,
0.018824333,
-0.003226568,
-0.008348463,
-0.011829675,
0.04590043,
-0.033213343,
0.010630591,
-0.021815598,
-0.025825439,
0.027256602,
0.002178981,
-0.014182717,
0.028932743,
-0.022782601,
-0.020745447,
-0.009296127,
-0.029319543,
0.018373065,
0.0073363325,
0.021261182,
0.018153878,
0.011816782,
-0.004077531,
-0.0071945055,
0.0053249653,
-0.018540679,
0.022679454,
-0.02311783,
0.036333542,
-0.012268051,
0.008219529,
0.036514048,
0.028262287,
-0.00942506,
0.01980423,
-0.033368066,
-0.02052626,
0.041490894,
-0.012429218,
-0.018128091,
-0.0074265865,
-0.01793469,
-0.0077424743,
-0.020087885,
0.012667744,
-0.0077747074,
-0.00008174201,
0.021544836,
-0.012816018,
0.004261262,
-0.011391301,
-0.0033651718,
-0.02792706,
0.024781074,
0.0052024783,
-0.039015364,
-0.013989316,
-0.019120881,
0.008857751,
-0.03006736,
-0.01762525,
-0.009998815,
0.00067770825,
0.010159982,
-0.018476212,
0.014621092,
-0.006478923,
-0.0019501236,
0.007961662,
-0.011417087,
0.0044901194,
-0.011107646,
0.023594884,
-0.024897115,
0.00018896858,
0.014389011,
0.013937742,
-0.008232422,
0.0012909495,
-0.014891853,
-0.0054635694,
0.02950005,
0.009257446,
-0.016967686,
0.005798797,
0.009354146,
-0.0044901194,
-0.0069624246,
0.012990079,
0.00565697,
-0.0186954,
-0.022602092,
-0.03865435,
0.013434901,
0.012003736,
0.013538048,
-0.015162614,
-0.0040162876,
0.037339225,
0.007864961,
0.007768261,
-0.01123658,
-0.0026640943,
0.02617356,
-0.00238044,
0.005092885,
-0.0024529654,
0.019301388,
0.0018550348,
0.037597094,
0.0149434265,
-0.0010846555,
0.008071255,
0.0129127195,
-0.0028591068,
0.025335489,
-0.011101199,
-0.028855382,
0.0056601935,
0.010218003,
-0.0065143798,
-0.007858515,
0.022215292,
-0.015897537,
-0.0021290192,
-0.009837648,
0.020964634,
-0.024200872,
-0.0057053203,
0.022808388,
-0.015639668,
0.021222502,
-0.008122829,
-0.019378748,
0.012532365,
-0.02712767,
0.014904746,
0.0035037757,
-0.025722291,
0.016155403,
0.0015044962,
-0.0078004943,
0.01762525,
0.0043063886,
-0.010579018,
-0.026096199,
-0.0065369434,
0.012119777,
0.007117145,
0.0057085436,
-0.0090189185,
-0.025812544,
0.029886853,
0.025167875,
0.000052228257,
0.013054546,
0.022834174,
-0.025541784,
-0.01682586,
-0.012416324,
-0.0034844356,
-0.022408692,
-0.024729501,
-0.01651642,
0.01766393,
0.007600647,
0.012551704,
-0.0007284759,
-0.0007989866,
0.008696584,
-0.012235817,
0.013067439,
0.0065498366,
0.007097805,
-0.043089673,
0.009109172,
0.015020787,
0.03437375,
-0.018411744,
0.008329123,
-0.004851134,
0.010830439,
-0.009070492,
-0.005382986,
-0.0014077958,
0.012648405,
0.01770261,
0.01514972,
0.014131144,
0.00474154,
0.0040807542,
0.01805073,
0.010108409,
0.0022998564,
-0.03553415,
-0.040794652,
-0.0009549159,
-0.0015907206,
-0.009263893,
-0.014659772,
-0.02099042,
0.044559516,
0.022872854,
0.020036312,
0.014311651,
0.0051573515,
-0.0026495894,
0.023981685,
-0.0044933427,
0.004506236,
-0.009031812,
0.02911325,
0.0057053203,
0.016490633,
0.0026931046,
0.011855462,
0.015123934,
0.011417087,
0.011488001,
-0.012268051,
0.024239553,
-0.00847095,
0.01976555,
-0.0032588015,
-0.056473,
0.00852897,
0.0023884985,
-0.02331123,
0.02792706,
0.019752657,
-0.014427691,
0.056576148,
0.007561967,
-0.014144037,
0.012300284,
-0.0041645616,
0.009083386,
0.0036262628,
0.01407957,
0.0040259575,
-0.043863274,
-0.0035424558,
-0.005653747,
0.007162272,
-0.048401743,
-0.0037616433,
0.005189585,
0.019507682,
-0.0054377825,
0.01797337,
-0.002282128,
0.021544836,
-0.019713977,
0.012242263,
0.018450426,
-0.03354857,
-0.011881249,
0.041800335,
0.0012699978,
-0.01419561,
-0.009076939,
0.016439058,
0.021351436,
-0.026341174,
-0.006788364,
0.0034457555,
-0.0019791336,
0.011649168,
-0.030944109,
0.0036520497,
-0.0102889165,
-0.0072976523,
0.0132930735,
-0.018257024,
-0.03419324,
-0.008097042,
-0.0065498366,
-0.0087223705,
0.0014593693,
-0.013228606
] |
CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective cohort study evaluating overall and cancer mortality in relation to immunosuppressive drug exposure among patients with ocular inflammatory diseases. Demographic, clinical, and treatment data derived from medical records, and mortality results from United States National Death Index linkage. The cohort's mortality risk was compared with US vital statistics using standardised mortality ratios. Overall and cancer mortality in relation to use or non-use of immunosuppressive drugs within the cohort was studied with survival analysis. SETTING Five tertiary ocular inflammation | [
0.0003516222,
-0.0024430244,
0.022557147,
-0.049167115,
-0.012265116,
0.024050292,
-0.009618783,
-0.0004524428,
-0.001359828,
-0.007492386,
0.01723782,
0.0016564572,
0.019757502,
0.020010803,
-0.006359196,
0.0040261573,
0.05188677,
0.0024646884,
0.012071807,
-0.0024063624,
-0.010025399,
0.022730459,
-0.018277688,
0.010911954,
0.0015831331,
-0.0026413326,
-0.018650975,
-0.049700383,
-0.014544827,
-0.02355702,
0.010545333,
-0.0097521,
-0.011358564,
-0.017411131,
-0.015224742,
-0.0040594866,
0.006652492,
0.011911827,
-0.012105136,
-0.00724575,
0.013291652,
0.0039061727,
-0.010651986,
-0.00017414465,
0.008045649,
0.0054993047,
0.017264483,
-0.01602464,
-0.027489858,
0.005106021,
0.020450747,
0.0075057177,
0.007105768,
-0.0076190364,
0.015024766,
-0.009238832,
0.010265369,
0.012611738,
-0.011258576,
-0.009572123,
0.007639034,
0.0047060717,
-0.02565009,
0.0058125984,
-0.014571491,
0.021543942,
-0.006269207,
0.009338819,
0.0145981535,
-0.01051867,
0.048020594,
0.047300685,
-0.01990415,
-0.021183988,
0.020757375,
-0.016464585,
-0.02419694,
0.00010003943,
0.021797244,
0.01315167,
0.027489858,
-0.02954293,
0.00801232,
0.020824034,
-0.0024046958,
0.017277814,
-0.0066424934,
0.023130408,
-0.0034328992,
-0.015638022,
-0.0034562296,
0.0037195296,
0.0008319781,
0.011825171,
-0.0030329498,
0.02071738,
0.0039461674,
0.049060464,
0.0006053401,
-0.029142981,
-0.020570733,
-0.012725057,
-0.008772224,
-0.021637265,
-0.028476398,
0.002229718,
-0.0043661147,
0.0065691695,
0.026023375,
-0.013378308,
-0.008205629,
0.0390084,
-0.018864281,
-0.01375826,
-0.0035028905,
-0.0023697002,
0.023423705,
0.0141982045,
-0.025423452,
-0.03311581,
0.023383709,
-0.0023363712,
0.037701897,
-0.045114294,
0.014904782,
0.0065258415,
-0.042101342,
0.0030112858,
0.0029096322,
0.0014273195,
-0.009092184,
0.03375573,
0.011871832,
-0.0072990768,
-0.0022313844,
0.0195042,
-0.014344852,
0.00052285055,
-0.01537139,
-0.02783648,
-0.0080656465,
0.019330889,
0.010472009,
-0.011118594,
-0.003592879,
0.029916218,
0.031675994,
0.014664812,
-0.010292032,
0.0012273447,
0.0018331015,
-0.035008907,
-0.016331268,
0.0010748641,
0.014611485,
0.0011106929,
0.008545586,
0.01805105,
-0.021917228,
-0.0053893183,
-0.013018354,
-0.020504074,
0.010412017,
0.017731091,
0.023103746,
0.0067591453,
-0.0036162094,
-0.014438174,
-0.011631862,
0.0104653435,
-0.004316121,
0.054819733,
-0.010485341,
0.029276298,
-0.01375826,
0.024970176,
-0.008385606,
0.023637012,
-0.040794842,
-0.03308915,
-0.0148647865,
0.012165128,
0.021957224,
0.008845548,
-0.018904276,
0.002613003,
0.017104503,
0.013244992,
-0.013065014,
-0.025596764,
0.014104883,
0.020704048,
-0.0048527196,
-0.017037846,
-0.6279739,
-0.036795348,
0.009278826,
0.0050126994,
0.005106021,
0.04660744,
0.01893094,
0.01658457,
-0.007712358,
0.009205502,
-0.0033012491,
0.037008654,
-0.0002528847,
-0.023370378,
-0.0010140385,
-0.027569847,
-0.018344346,
-0.0137982555,
0.005932583,
-0.034902252,
0.0012923366,
0.0067658112,
0.011658526,
0.026023375,
0.011391893,
0.011238579,
0.022117203,
-0.02079737,
0.00031516847,
0.026263345,
-0.023623679,
0.023170404,
-0.0020780705,
0.00022268017,
0.05769937,
-0.014011562,
0.009965407,
-0.0087322295,
-0.006392525,
0.040821504,
-0.023397041,
-0.031036075,
0.029409613,
-0.007679029,
-0.030396156,
0.02322373,
0.03607544,
0.0049693715,
0.017597774,
-0.0014123213,
0.013518291,
0.015731344,
-0.026769947,
-0.017184494,
0.012531749,
0.00015018934,
0.018664306,
-0.02015745,
0.011005275,
-0.0018097712,
-0.0041761384,
0.015464711,
-0.026649963,
-0.012565077,
-0.03050281,
0.017037846,
-0.012871706,
0.019997472,
0.012898369,
0.0033012491,
0.0072790794,
0.010691981,
0.010218708,
-0.0044561033,
0.025823401,
0.013304984,
0.009258829,
0.010425348,
-0.01691786,
0.0036562043,
-0.005529301,
-0.0010248704,
-0.014024893,
0.00445277,
0.016037973,
-0.027409866,
-0.012725057,
0.0067291493,
-0.014558159,
-0.0014298192,
0.013771592,
0.02202388,
0.0045494246,
-0.016157957,
-0.00096987735,
0.004682741,
-0.01327832,
0.0103320265,
0.014384847,
-0.017784419,
-0.008345611,
0.0035662157,
0.012591741,
0.009332153,
-0.008518923,
0.018530989,
-0.023663674,
0.017531116,
0.04274126,
-0.013404972,
0.012958362,
0.0037628575,
0.014438174,
-0.014011562,
0.045380928,
-0.017611107,
0.013944903,
-0.006919125,
0.0031446023,
-0.021024007,
0.017051177,
0.00028413074,
0.019357553,
-0.0027279884,
0.01299169,
-0.003022951,
-0.027543183,
0.0010315363,
0.008112308,
-0.031089403,
0.024863522,
-0.011825171,
0.015864661,
0.0005041029,
0.016051304,
-0.021797244,
0.024010297,
-0.005409316,
-0.014371516,
-0.0074323933,
-0.03002287,
-0.005622622,
0.008185632,
0.018437669,
-0.0076456997,
-0.0089988625,
-0.0074723884,
0.0073190746,
0.018517658,
0.005096022,
0.009445473,
-0.01249842,
0.0057259426,
0.018557653,
0.010225373,
-0.0059659122,
-0.01650458,
-0.011018607,
-0.02087736,
-0.0016439587,
0.00796566,
0.009825424,
-0.011918493,
-0.0020264103,
-0.03066279,
-0.006025905,
-0.016664559,
0.021277308,
0.0065558376,
-0.022757122,
-0.015491375,
-0.025050165,
-0.00030516973,
0.018424336,
-0.0011690188,
-0.0049027135,
-0.025876727,
-0.009738768,
0.0022713793,
0.009552126,
0.0083922725,
-0.036448725,
0.0058992538,
0.01593132,
0.02751652,
-0.005186011,
0.0112652425,
0.0051326845,
-0.010092057,
0.04263461,
0.0027363207,
0.01691786,
-0.025876727,
0.030636126,
-0.00045494246,
-0.03447564,
-0.00558596,
0.0052759997,
0.013331647,
0.011138591,
0.02378366,
-0.03194263,
0.035008907,
-0.012318443,
0.0039928285,
0.0076990263,
-0.003632874,
-0.012251784,
0.024303593,
-0.0061958833,
0.013411637,
0.011905161,
0.0026013376,
-0.001125691,
0.01315167,
0.010305364,
-0.0017364471,
-0.018451,
-0.0053126616,
0.0029462941,
-0.0029662915,
0.00075823744,
0.023610348,
-0.0339957,
0.0073923985,
-0.006092563,
0.03327579,
-0.00616922,
0.016291274,
-0.020984013,
-0.03324913,
-0.00016039639,
0.0064125224,
0.009865419,
0.013484961,
0.014798129,
-0.010845295,
-0.018091045,
0.040901493,
0.00495604,
0.005592626,
0.019930813,
0.023383709,
0.011431888,
-0.012451759,
-0.003154601,
0.01415821,
0.00047410672,
-0.0041361437,
-0.0054626428,
-0.00434945,
-0.004379446,
-0.0013214996,
-0.0078723375,
-0.008585581,
-0.016557906,
-0.005492639,
0.0001086321,
0.045594234,
0.032155935,
0.02654331,
-0.0050560273,
0.015291399,
0.0032795852,
0.0008336446,
0.010185379,
-0.0119318245,
0.020997345,
0.0048893816,
-0.011105263,
-0.043967772,
-0.008665571,
0.024463573,
-0.022103872,
0.0080656465,
0.018637642,
0.010898622,
0.017824413,
0.018344346,
-0.0011465217,
-0.0055659628,
-0.029142981,
0.016811207,
0.0136649385,
0.0067958073,
-0.015451379,
-0.007225753,
0.0034595625,
-0.003666203,
0.009478801,
0.02598338,
0.012218455,
-0.0062958705,
-0.008158968,
-0.00041036477,
-0.0039061727,
0.023023754,
-0.024170278,
-0.0059959083,
-0.0173978,
-0.0067058187,
-0.01569135,
0.009252164,
0.009558791,
0.008985531,
-0.0015698015,
-0.009918746,
-0.02831642,
-0.028956339,
0.008892209,
0.0026563308,
-0.006575835,
-0.011345232,
0.017224489,
0.02646332,
0.008578915,
-0.011505212,
-0.0044860994,
0.011185252,
0.0014239866,
0.0054293135,
-0.0339957,
0.004582754,
-0.020184115,
0.02954293,
0.019237567,
0.000780318,
0.040981483,
0.04143476,
0.015291399,
-0.00054243143,
-0.028183103,
-0.0053059957,
-0.013578283,
-0.025303466,
0.0065491716,
0.008285619,
0.0067891413,
0.0152647365,
0.026116697,
0.0050193653,
-0.013038351,
-0.010218708,
-0.0014406511,
-0.016944524,
0.00029683748,
0.032662537,
0.021823907,
0.023663674,
-0.011625197,
0.010445346,
0.021250647,
0.01383825,
0.00732574,
-0.014478169,
0.030876096,
-0.0015089759,
0.017944397,
-0.020024134,
-0.043647815,
0.037248623,
0.004849387,
0.00093988114,
-0.005982577,
0.026663294,
0.0075390465,
0.0044494374,
-0.020037467,
0.01982416,
-0.013238326,
-0.0065558376,
0.018104378,
-0.01593132,
-0.007412396,
0.018597648,
-0.007145763,
-0.0054726414,
-0.040501546,
0.0039495006,
0.015864661,
-0.0045660893,
0.0033729067,
-0.0072390847,
-0.0038395145,
-0.0065258415,
-0.023930307,
-0.011631862,
-0.010978612,
-0.030289503,
-0.008925538,
-0.04218133,
-0.011685189,
-0.010618657,
-0.016037973,
0.03626208,
-0.013824918,
0.00033724902,
0.011898495,
-0.0050893566,
0.0075057177,
0.023277057,
-0.01570468,
0.010898622,
0.003999494,
0.005559297,
0.023956971,
-0.008972199,
-0.03860845,
0.0030546137,
-0.0008907207,
-0.004379446,
-0.0044394387,
-0.028743032,
0.031755984,
-0.017611107,
-0.011325235,
-0.019117583,
-0.012125134,
0.005209341,
0.005815931,
0.0067524794,
0.021583937,
-0.024050292,
-0.022957098,
0.0077323555,
-0.012698394,
-0.02411695,
-0.012565077,
0.003099608,
-0.02225052,
-0.008452265,
0.019477537,
0.013984898,
0.005669283,
0.008798887,
-0.016784545,
-0.0009865419,
-0.020330762,
-0.0011873499,
0.018277688,
-0.01205181,
0.03042282,
0.0187043,
0.00093738147,
0.0007532381,
0.013284987,
0.018344346,
-0.011985151,
-0.009938743,
-0.023277057,
-0.023263725,
-0.026090033,
-0.035168886,
-0.0105986595,
-0.0029229636,
0.020837365,
-0.013045017,
-0.025116824,
-0.012191792,
-0.0075657098,
-0.0050260313,
0.012725057,
-0.00067741435,
-0.012678397,
0.0041028145,
-0.0049360422,
-0.01715783,
-0.017584443,
0.033222467,
-0.026250014,
-0.011431888,
0.002967958,
0.02290377,
-0.020610727,
0.0023780325,
-0.003194596,
-0.021197319,
0.018024387,
-0.02735654,
-0.038848422,
-0.00020799453,
-0.016877865,
0.048767168,
0.038475133,
0.03844847,
-0.0072724135,
0.013091678,
0.009725437,
0.008738895,
0.011765179,
-0.003819517,
0.016611233,
0.013098343,
0.009278826,
-0.0029512935,
-0.010192044,
0.02549011,
-0.0032662535,
0.0056492854,
0.0029729574,
-0.018451,
-0.022943765,
-0.024970176,
-0.02654331,
-0.024743538,
0.01990415,
-0.001425653,
0.020037467,
-0.028209766,
-0.011705186,
0.0043327855,
0.01803772,
-0.0015014767,
-0.0115318755,
-0.006572502,
-0.028689705,
0.007938996,
-0.01690453,
-0.001652291,
-0.008032317,
0.0147314705,
0.009012193,
-0.015824666,
0.00036745353,
0.0047660638,
0.017664433,
0.03236924,
-0.023397041,
0.014798129,
0.008278953,
-0.021423958,
-0.005292664,
0.0072390847,
-0.023330383,
0.010878624,
0.004652745,
-0.017637769,
-0.0076190364,
0.0041961363,
0.00978543,
-0.01749112,
0.01117192,
-0.020064129,
-0.02265047,
-0.011985151,
-0.03324913,
0.016011309,
-0.03618209,
0.01958419,
0.02145062,
-0.03018285,
-0.0024480238,
-0.006239211,
0.019864155,
-0.0103320265,
0.025463447,
0.020304099,
-0.0053926515,
-0.0076590315,
0.0023946972,
0.0025046833,
-0.0133983055,
-0.026050039,
0.0068324693,
0.026943259,
0.01497144,
-0.031196054,
-0.02379699,
-0.043167874,
0.012211789,
-0.006845801,
-0.02533013,
-0.0013714932,
-0.023010423,
-0.0011031938,
0.012858374,
-0.022757122,
-0.005712611,
0.0148647865,
-0.007905667,
-0.011971819,
-0.010845295,
0.004919378,
0.0055692955,
-0.010951948,
0.020010803,
-0.006925791,
0.0012040144,
0.0035828801,
-0.010425348,
0.027129903,
-0.0012298445,
-0.031116065,
0.040661525,
0.0042994563,
-0.006655825,
0.016571239,
-0.010172047,
0.008898875,
-0.022677133,
-0.0091321785,
-0.008725563,
-0.011791842,
0.010132052,
0.02710324,
0.022770453,
-0.021210652,
0.005925917,
-0.019424211,
-0.010032064,
0.0018597648,
-0.012451759,
-0.0038061854,
-0.0072857453,
0.0047727297,
0.0002860055,
0.004619416,
-0.0131916655,
0.0106719835,
-0.016304605,
0.011065267,
-0.009438806,
-0.028049786,
0.019944144,
0.023330383,
-0.0048327222,
-0.0347956,
0.011678523,
-0.0411148,
-0.04044822,
-0.005212674,
-0.004042822,
-0.06996448,
-0.031116065,
-0.020384088,
0.017757755,
0.0093988115,
-0.014744802,
0.022277182,
0.025316799,
0.018224362,
-0.0173978,
-0.019224236,
0.032955833,
-0.020570733,
0.008752227,
0.020517405,
-0.008852214,
0.018437669,
-0.0029512935,
0.03050281,
0.0075857076,
-0.022717128,
-0.006379193,
-0.0297829,
0.0040261573,
0.009032191,
0.004156141,
-0.0055459654,
-0.0013848249,
-0.019730838,
0.020677386,
0.019997472,
0.00334791,
0.0047094044,
-0.0173978,
0.0035762144,
0.0064425184,
-0.008518923,
-0.019957475,
-0.021383962,
-0.0035062232,
-0.012145131,
-0.0047827284,
-0.001721449,
0.05913919,
0.0053659882,
0.0128650395,
-0.045674223,
-0.0015356392,
-0.042421304,
0.024663547,
0.010372022,
0.014678144,
0.0058792564,
-0.007612371,
-0.0081256395,
0.036768682,
-0.020344093,
0.0038261828,
-0.008832216,
-0.03852846,
0.0033895713,
-0.024570227,
0.036768682,
0.002288044,
-0.02379699,
-0.0024430244,
0.009318821,
-0.0062092147,
-0.0047593983,
0.02435692,
0.003706198,
-0.0038795094,
-0.010871959,
0.0036095434,
-0.038901746,
-0.012365103,
-0.010578662,
-0.025543436,
-0.014838124,
0.012871706,
-0.004002827,
0.0069324565,
0.0067924745,
0.010452012,
-0.013184999,
0.0080656465,
-0.0047360677,
-0.0136649385,
-0.0093988115,
-0.011458551,
0.0051226853,
0.032742526,
0.012818379,
0.00627254,
0.0010998609,
-0.011711853,
-0.021917228,
-0.00097154384,
0.009898748,
-0.006305869,
0.0017114503,
-0.004382779,
-0.0121984575,
0.002061406,
0.006012573,
0.004009493,
-0.009332153,
-0.0059125856,
0.004192803,
-0.015304731,
0.012645068,
0.0042494624,
0.002496351,
0.0015656353,
-0.008345611,
-0.014931445,
-0.026436657,
-0.006129225,
-0.008752227,
-0.031116065,
-0.001578967,
0.008112308,
-0.0026379998,
0.027463194,
-0.0049727047,
-0.021570606,
-0.027143234,
0.031596005,
0.19538863,
-0.0034762272,
0.012618404,
0.0128650395,
-0.013851582,
0.009925411,
0.03746193,
-0.015291399,
-0.0103320265,
0.026516646,
0.01254508,
-0.019930813,
-0.003062946,
0.0075857076,
0.026476651,
0.0007244917,
-0.026103366,
-0.01803772,
-0.010192044,
-0.006809139,
-0.014024893,
0.011591868,
-0.001228178,
-0.0036195423,
0.014531496,
0.013464964,
0.012251784,
0.026330004,
0.01835768,
-0.009238832,
-0.0036528714,
-0.021597268,
0.0047160704,
-0.011831837,
0.01193849,
-0.0041094804,
-0.014251531,
-0.04119479,
0.0005336825,
-0.01811771,
-0.011738515,
0.012211789,
-0.014584823,
-0.000064783475,
0.016077967,
0.027863143,
-0.008212294,
0.0032212592,
-0.030449484,
-0.019597521,
-0.03714197,
-0.025583431,
0.015078093,
-0.005809265,
0.012118467,
0.0032312581,
0.043407843,
-0.0067558126,
-0.0014723138,
-0.0063391984,
0.018837618,
0.0030312834,
-0.031542677,
0.01067865,
-0.02686327,
0.016557906,
-0.017837744,
-0.0000855621,
-0.03132937,
-0.012071807,
-0.010025399,
-0.0046727424,
-0.027076576,
0.0014623151,
0.014784797,
-0.011431888,
-0.01270506,
0.0255701,
-0.002594672,
0.044207744,
-0.005865925,
0.00064783473,
-0.025450114,
0.030156186,
-0.044314396,
-0.006429187,
0.022677133,
-0.013284987,
-0.010985278,
0.03562216,
-0.0071990895,
-0.0029729574,
-0.009125513,
-0.020197446,
0.03714197,
-0.009658779,
0.019877486,
0.019077588,
-0.0014406511,
0.00917884,
-0.030636126,
0.09428141,
0.015358058,
0.006582501,
0.017464459,
-0.0141982045,
-0.026729953,
0.02994288,
-0.0052360045,
0.0018897611,
0.029516267,
-0.03375573,
-0.0072790794,
-0.015917987,
-0.019957475,
0.034022365,
-0.009552126,
-0.015238073,
0.01747779,
-0.0049460414,
0.0014523163,
-0.03714197,
0.0045627565,
0.025943385,
0.006552505,
-0.010991943,
-0.028343083,
-0.015758008,
-0.009472135,
-0.026023375,
0.0148647865,
0.0019730837,
0.012585076,
0.02014412,
0.018411005,
-0.00732574,
-0.0004920211,
-0.021010676,
-0.013544953,
0.037915204,
-0.019890819,
-0.01803772,
-0.011051936,
-0.0052759997,
0.015078093,
-0.0068324693,
-0.0066058314,
0.008078978,
-0.016437922,
-0.011545206,
0.00014175291,
-0.023010423,
-0.0016156291,
0.0028079783,
0.009418809,
-0.01537139,
-0.013118341,
-0.026103366,
-0.013564952,
0.020664053,
-0.018970935,
0.0061758854,
0.029036328,
0.003666203,
-0.01813104,
0.014051557,
-0.16701888,
0.00724575,
0.02137063,
0.0058825896,
0.026743285,
-0.023277057,
0.013851582,
0.00046369137,
-0.008205629,
-0.011945156,
0.01682454,
0.008272287,
-0.021503948,
-0.03260921,
0.008972199,
0.0059792437,
-0.001421487,
0.053379916,
0.02614336,
0.020317432,
0.021663927,
-0.009152176,
0.0081256395,
-0.021490615,
-0.010418682,
0.013904909,
0.012031812,
0.004309455,
-0.007339072,
-0.006052568,
-0.029062992,
-0.007899001,
0.032955833,
0.0155313695,
-0.01803772,
0.010092057,
-0.016491247,
0.012958362,
0.006199216,
0.023703668,
0.014371516,
0.022490488,
0.009778763,
0.010318696,
-0.024076955,
0.016077967,
0.015358058,
-0.004409442,
0.03356909,
-0.0010223708,
0.025596764,
-0.022837112,
-0.028929675,
-0.006655825,
-0.0155313695,
-0.001999747,
0.030262839,
0.0062158806,
0.0023863649,
-0.00053868187,
-0.01101194,
-0.021797244,
0.032235924,
0.0030912757,
0.012278447,
-0.028103113,
-0.007865672,
0.008205629,
-0.01307168,
0.011558538,
-0.044261068,
0.015718013,
0.02137063,
0.01861098,
0.024530232,
0.012271781,
0.007985657,
0.01821103,
0.002781315,
0.0011240245,
-0.006905793,
-0.017611107,
-0.012531749,
0.006812472,
0.0071257656,
0.025183482,
0.02193056,
0.028183103,
0.011385227,
-0.009158841,
0.02323706,
-0.034742273,
0.026969923,
-0.0021547275,
0.004812725,
0.031196054,
-0.005485973,
0.014184873,
0.019637516,
0.0016064636,
0.00059700786,
-0.021077335,
-0.012791716,
-0.0034762272,
0.0012065141,
-0.020544069,
0.0042194664,
-0.014024893,
0.018144373,
-0.034848925,
0.013038351,
0.017637769,
-0.0037528588,
-0.0034695612,
-0.009678776,
-0.0031079403,
-0.006572502,
0.00437278,
-0.035142224,
-0.0234637,
0.06900461,
-0.0007994822,
0.0074323933,
-0.0075390465,
-0.012365103,
-0.019370884,
-0.12243785,
-0.021943891,
0.017517785,
-0.010145384,
-0.012931698,
0.024316926,
0.0053359917,
0.0043694475,
-0.03228925,
0.019930813,
-0.0019080921,
-0.0012990024,
-0.024183609,
-0.012605073,
0.03599545,
-0.012511751,
0.015624691,
-0.047807287,
-0.019637516,
0.043167874,
0.000020140682,
0.0012440094,
0.0024496901,
-0.0068724644,
-0.007179092,
0.0020880692,
0.0067124846,
0.01902426,
-0.0012890036,
0.037061978,
0.0020664053,
0.01481146,
-0.0017247819,
0.0055726287,
-0.010318696,
0.011165255,
-0.01602464,
-0.03130271,
0.03927503,
-0.03788854,
-0.017064508,
0.019730838,
0.0032962498,
-0.010978612,
-0.0028696372,
0.01315167,
-0.017251153,
-0.0042827916,
0.028343083,
-0.009818758,
-0.010831963,
-0.04028824,
0.004992702,
0.008278953,
0.008438933,
-0.015198078,
-0.005705945,
-0.0017981059,
-0.030822769,
0.01869097,
0.016171288,
0.021210652,
-0.01957086,
-0.00046369137,
-0.0017831079,
-0.0331958,
-0.013358311,
-0.023970302,
-0.008638907,
-0.03498224,
-0.020104125,
-0.0101387175,
-0.020584064,
0.0006761645,
-0.0171445,
-0.023863649,
-0.0006165887,
-0.023756996,
-0.0033312454,
-0.018810954,
-0.011965154,
-0.0024263598,
0.019784166,
-0.002288044,
0.019624185,
0.0123317735,
0.022743791,
-0.006005907,
-0.00039828298,
-0.008445598,
-0.0050460286,
0.028156439,
0.013904909,
-0.014384847,
0.0028229763,
-0.00221472,
-0.0033145808,
-0.013578283,
0.037195295,
0.0039028397,
-0.008672236,
-0.006692487,
-0.056312878,
0.026276678,
-0.0032945834,
0.0009298824,
0.0029112985,
-0.003712864,
0.01594465,
-0.015611359,
0.01779775,
0.0067558126,
-0.025850065,
0.0078123454,
-0.017997725,
0.01829102,
-0.020837365,
-0.010425348,
0.0077990135,
0.008892209,
0.033435773,
0.030822769,
0.006039236,
0.00065700023,
0.01707784,
0.011018607,
-0.0016789543,
0.00890554,
-0.0031262713,
0.016251279,
-0.015611359,
-0.008212294,
0.003146269,
-0.013618278,
-0.005142683,
-0.0048327222,
-0.018451,
-0.031436026,
0.024916848,
0.033329118,
0.0072124214,
0.01602464,
-0.02290377,
-0.02233051,
0.015664686,
-0.0071324315,
-0.002174725,
-0.021143993,
-0.024023628,
0.035248876,
0.010831963,
-0.019997472,
0.008925538,
0.010711979,
-0.020397421,
-0.006119226,
-0.008425601,
0.012031812,
0.01067865,
0.0112052495,
-0.02597005,
-0.011038604,
-0.016051304,
-0.0013314983,
-0.028396409,
0.0137982555,
0.040341564,
-0.01602464,
-0.019117583,
-0.005749273,
0.016851202,
-0.0023180402,
-0.043194536,
0.00906552,
-0.008358943,
0.0068324693,
0.016464585,
0.00042994562,
-0.011711853,
0.023210399,
-0.00139649,
0.010698647,
0.032582548,
0.011951822,
-0.0028846352,
0.027223224,
0.026023375,
0.012445093,
-0.02323706,
0.037435267,
0.009105515,
-0.011691854,
-0.015518038,
0.01481146,
-0.014238199,
0.0033329118,
-0.0003809935,
0.020904023,
0.01465148,
0.013344979,
0.01067865,
0.037088644,
0.0059559136,
0.013085012,
0.0050126994,
-0.01056533,
-0.011078599,
0.027863143,
-0.022850445,
-0.035755478,
-0.045994185,
0.032982495,
0.024396915,
0.020210778,
0.0029796232,
-0.000049889524,
-0.011365229,
0.0030729447,
0.0155313695,
-0.007679029,
-0.0015006436,
0.015291399,
-0.019597521,
0.0005236838,
-0.012278447,
-0.018517658,
0.00991208,
0.021064002,
0.020930687,
-0.038288493,
0.044927653,
0.007712358,
0.037568584,
-0.012351771,
-0.024943512,
-0.011711853,
-0.0022030547,
-0.037568584,
0.018451,
-0.005555964,
-0.003322913,
0.07257749,
0.0093988115,
-0.009358817,
-0.015438048,
-0.0036562043,
-0.0012665065,
-0.0069524543,
0.025996713,
-0.018504327,
-0.035382193,
0.015478043,
-0.0038228498,
0.0108652925,
-0.039541665,
-0.017451126,
-0.005685948,
-0.0023963635,
0.023250394,
0.000022223752,
-0.024716875,
0.018664306,
-0.00096654444,
0.0096654445,
0.006589167,
-0.0151314195,
-0.02257048,
0.006162554,
-0.016277941,
-0.009592121,
-0.032875843,
0.004462769,
0.03220926,
-0.0149981035,
-0.01489145,
0.018384341,
-0.0046360805,
-0.0058925883,
-0.0213573,
-0.0024830194,
-0.004316121,
-0.015904656,
0.0072857453,
-0.018864281,
-0.021024007,
0.00061533885,
-0.02087736,
-0.03844847,
-0.00930549,
-0.005889255
] |
Follicular T helper (TFH) cells orchestrate the germinal center (GC) reaction locally. Local mechanisms regulating their dynamics and helper functions are not well defined. Here we found that GC-expressed ephrin B1 (EFNB1) repulsively inhibited T cell to B cell adhesion and GC TFH retention by signaling through TFH-expressed EPHB6 receptor. At the same time, EFNB1 promoted interleukin-21 production from GC TFH cells by signaling predominantly through EPHB4. Consequently, EFNB1-null GCs were associated with defective production of plasma cells despite | [
-0.036137782,
0.012386683,
-0.010547931,
-0.0033273445,
-0.014895882,
-0.0060506226,
-0.029924527,
0.010255855,
0.0019914282,
-0.018241482,
0.023963518,
-0.021202073,
-0.0005717058,
0.010826731,
-0.022303995,
-0.00040720557,
0.030721098,
-0.01504192,
-0.028809328,
0.021892434,
-0.021852605,
0.024614051,
0.004646666,
-0.020777233,
-0.010401893,
0.02392369,
0.007872779,
-0.061654616,
-0.01682093,
-0.009153931,
0.002970547,
0.0012728545,
-0.010806817,
0.01615712,
-0.007945798,
-0.023658166,
0.00776657,
-0.019754967,
0.024361804,
0.019197367,
0.033509098,
0.0047064084,
-0.014882606,
0.0071890554,
-0.008204684,
0.009306608,
0.0070496555,
-0.0016313116,
-0.020432053,
0.037146773,
0.003002078,
-0.0070562935,
-0.007580703,
-0.013395674,
-0.031384908,
0.0035746135,
0.0014288496,
0.011390969,
0.0003391651,
-0.026499271,
-0.017152835,
0.0055660415,
-0.0159447,
-0.0024992423,
0.006306189,
0.009917312,
0.00682396,
0.013249636,
-0.0021689972,
-0.0075342366,
0.010235941,
0.02006032,
-0.019808073,
-0.0016877353,
0.021640185,
-0.019622205,
-0.011530369,
0.021786224,
-0.0064721415,
-0.0022967805,
0.014364835,
-0.020259462,
-0.010693969,
0.037810583,
0.004676537,
0.00073890283,
0.013939997,
0.024879575,
0.016276605,
-0.008702541,
0.013329293,
0.0072952653,
0.014006378,
0.022171233,
0.008443655,
0.00459688,
0.00818477,
0.04112963,
0.008251151,
-0.019170815,
-0.012094607,
0.015599521,
-0.005028356,
-0.008968065,
-0.035473973,
-0.0054565133,
0.0077532935,
-0.0049984846,
0.014218797,
-0.010302322,
-0.020086871,
0.02392369,
-0.013448779,
-0.031836297,
0.014656912,
0.009173846,
0.0010280748,
-0.029127955,
-0.00916057,
-0.004261656,
0.0039164755,
0.027694127,
0.01375413,
-0.022171233,
0.0050549083,
0.015466759,
-0.00071401,
-0.010667417,
-0.013767406,
0.0009807784,
0.024321975,
0.010162922,
0.008131665,
-0.0001657449,
-0.020113423,
0.0021756352,
-0.023233328,
-0.022476586,
-0.014232073,
-0.008855217,
0.000025242907,
0.03465085,
0.00640908,
0.018639768,
0.008755646,
0.03388083,
0.008437017,
0.005589275,
0.024560947,
0.011138721,
-0.02027274,
0.007461217,
0.025025614,
-0.009339798,
0.00832417,
-0.009074274,
-0.021188796,
0.05533515,
-0.006535203,
-0.028092412,
0.00849676,
-0.027030317,
0.022622624,
-0.014232073,
0.026578927,
0.022104852,
-0.014683464,
0.017763538,
0.027800336,
0.011377693,
0.008437017,
0.019993939,
-0.028809328,
-0.002939016,
-0.0067675365,
0.003896561,
0.0029240802,
0.003534785,
-0.0036310374,
-0.030375917,
-0.0054200036,
0.036270544,
0.03165043,
-0.012287112,
-0.01587832,
0.0026369828,
0.019303577,
-0.018347692,
-0.013269549,
-0.016396092,
-0.026140813,
0.0135815395,
0.009273417,
-0.016661616,
-0.6232374,
-0.001222239,
0.038023002,
0.00006648466,
-0.00038417967,
0.02482647,
-0.014152416,
-0.009180483,
-0.03207527,
0.006601584,
-0.021162244,
0.032685973,
-0.012200817,
-0.023379367,
-0.0147896735,
-0.04495317,
-0.011490541,
-0.008675989,
0.022025196,
0.002907485,
-0.0028062542,
-0.0051943082,
-0.0005833225,
0.016143844,
0.012081331,
0.0034816803,
0.02130828,
-0.0013541712,
-0.0023598424,
0.030588336,
-0.002203847,
0.030508678,
0.0017956044,
-0.016874034,
0.0536358,
-0.0056490176,
-0.0035912087,
0.01828131,
-0.0047595133,
0.031809747,
-0.009346436,
-0.004384461,
0.001832114,
-0.010508102,
-0.012977473,
0.028251728,
-0.01755112,
0.0063924845,
0.0036310374,
-0.02368472,
0.009392903,
0.0049022324,
-0.017418358,
0.013276188,
0.015758835,
0.011995035,
-0.00807856,
0.00083349564,
0.0011882188,
0.010873198,
0.010103179,
0.02051171,
-0.04651976,
0.000710276,
-0.01103915,
-0.009446007,
-0.011450712,
0.0007065421,
0.00025888567,
-0.00089365337,
-0.0008588034,
0.029844869,
-0.015931426,
0.010873198,
0.023180224,
0.024229042,
0.0026369828,
0.008191408,
-0.0096650645,
0.012453064,
-0.01083337,
-0.009704893,
-0.011503817,
0.021719843,
0.016289882,
-0.012585826,
-0.029526241,
0.012977473,
-0.028596908,
0.005320432,
-0.00003344977,
0.0021756352,
0.00025847077,
-0.03321702,
-0.006296232,
0.023591785,
-0.007899332,
0.0070430175,
0.007142589,
-0.019383233,
0.0021125732,
-0.02336609,
0.0021756352,
-0.007832951,
0.01243315,
0.0031282017,
-0.040094085,
0.024056451,
0.052998543,
-0.033376336,
-0.0073749223,
0.010202751,
-0.019741692,
0.012990749,
0.020432053,
-0.014537426,
0.03576605,
0.015918149,
-0.0027498303,
-0.0046864944,
0.019662034,
-0.0054996605,
-0.00022196127,
-0.010647503,
0.024215767,
0.020883443,
-0.0033837683,
-0.015214511,
-0.024468014,
0.008954789,
0.0103222355,
0.0051611178,
0.041103076,
-0.013256273,
0.03555363,
0.0058448417,
0.010016884,
-0.0031813064,
0.009060998,
-0.048139457,
-0.051591266,
-0.017298872,
0.016674891,
-0.0033074303,
-0.0001682342,
-0.0039463467,
0.00658167,
-0.003757161,
0.0064953747,
0.0066746036,
0.01570573,
0.008204684,
-0.01271195,
0.0050416323,
0.017909577,
-0.014497597,
-0.009452646,
-0.017418358,
-0.0008239534,
-0.021587081,
-0.00233329,
0.012877902,
-0.005662294,
0.01083337,
-0.028437594,
0.0030999898,
-0.0023814163,
0.022423482,
0.01340895,
-0.03730609,
-0.0054797465,
-0.02894209,
-0.019250473,
0.02838449,
-0.010275769,
-0.006236489,
-0.01615712,
0.0009807784,
0.0028742945,
-0.014948987,
-0.012831436,
0.006070537,
-0.009592046,
-0.0015159746,
0.041288942,
0.0034219373,
0.009452646,
0.0077599315,
0.0035546992,
0.019250473,
-0.003816904,
-0.003297473,
-0.028995194,
0.028437594,
-0.0043014847,
-0.03767782,
0.026685137,
0.020246185,
-0.008549864,
0.03879302,
-0.020139977,
-0.019648757,
0.038978886,
-0.010594398,
0.020644471,
-0.015347273,
-0.015161406,
-0.02156053,
0.014670188,
0.0023830757,
-0.00024042345,
0.0016952032,
-0.0065252464,
0.00044392253,
-0.00278634,
0.0004443374,
-0.009877483,
0.02531769,
-0.0022171233,
-0.021706566,
0.0048325323,
-0.00734837,
0.020631196,
0.021029482,
-0.0057917368,
0.0021258495,
0.017922854,
-0.013886892,
-0.0019184091,
-0.010554569,
-0.014975539,
0.0056788893,
-0.0028693161,
-0.009804465,
-0.0011674748,
0.0076138936,
0.013462055,
-0.013223083,
0.04718357,
-0.0056855273,
0.014736569,
0.012871264,
-0.0044939895,
0.007202332,
-0.012260559,
-0.028543804,
0.010335512,
-0.0003827276,
0.010036798,
0.026977213,
0.013316017,
0.0192903,
-0.00033273446,
-0.023153672,
0.0135682635,
0.0020113424,
0.00341198,
-0.0027797017,
0.037359193,
0.036137782,
0.0052673277,
-0.015254339,
0.0187327,
-0.04158102,
-0.007932522,
0.011244931,
0.0035679755,
-0.015506587,
-0.032367345,
-0.0009409498,
-0.018679596,
0.013136787,
0.0024843067,
-0.037837137,
0.027017042,
0.008490122,
0.035473973,
0.013209807,
0.005994199,
-0.00046425167,
-0.0056888466,
-0.025251308,
0.010919664,
0.032792185,
-0.008875132,
-0.0031099468,
-0.030800756,
-0.008038731,
-0.0011093915,
0.008549864,
-0.004314761,
0.027123252,
-0.003367173,
-0.019064605,
-0.0012487913,
-0.018201653,
0.0013948295,
0.0035546992,
0.004467437,
-0.0033422802,
-0.0129376445,
-0.0220783,
-0.023352815,
-0.004971932,
0.019489443,
0.006780813,
-0.020657748,
-0.01832114,
-0.009538941,
-0.016502302,
0.014537426,
-0.002326652,
0.0054067275,
-0.012107884,
-0.00039475915,
0.00044143325,
0.009041084,
0.014962263,
0.032579765,
0.0016362901,
-0.030429022,
-0.019555824,
-0.007832951,
-0.01723249,
0.027056871,
0.013481969,
-0.008682626,
0.023113843,
0.008689265,
-0.003468404,
-0.0039264327,
-0.023034185,
0.01364792,
-0.016794378,
-0.01142416,
0.0053469846,
-0.003913156,
-0.0049254657,
-0.010381979,
0.009777912,
-0.017152835,
-0.01605091,
0.01236013,
0.002552347,
-0.012094607,
0.0050582276,
0.012386683,
0.023910414,
-0.0024926043,
0.014776397,
0.005350304,
0.028437594,
-0.0026718327,
-0.012579188,
0.0017640734,
0.00849676,
0.008071922,
0.015121577,
-0.00752096,
-0.03284529,
-0.012021588,
0.009738084,
0.015108301,
-0.015825216,
0.0181751,
0.017325426,
0.009140655,
-0.006083813,
-0.00047586835,
0.007866141,
0.013939997,
0.014763121,
-0.018400796,
0.00038355734,
0.023312986,
-0.0229147,
0.0012512807,
-0.011331226,
-0.02225089,
0.01413914,
0.0056722513,
-0.012227369,
0.0040724706,
-0.019210644,
-0.010567846,
-0.024945956,
0.015307444,
0.01598453,
-0.005151161,
0.005798375,
-0.00006243957,
-0.019768244,
0.004530499,
-0.020591367,
-0.002022959,
-0.030535232,
-0.041527916,
0.006734346,
0.029924527,
0.010143007,
0.023273157,
0.009426094,
-0.0057585463,
0.019263748,
-0.008609608,
-0.030561784,
-0.0026917472,
-0.018055616,
0.009207036,
0.011390969,
0.009120741,
-0.008543227,
-0.024335252,
0.0022901425,
-0.004474075,
-0.026207194,
0.02594167,
-0.013515159,
-0.012194178,
0.011915378,
0.032367345,
0.021958815,
0.0054830653,
-0.0041388515,
-0.024574224,
-0.00058664154,
-0.014019654,
-0.008237874,
0.008815388,
-0.0008413784,
0.009134017,
0.0067011556,
-0.025105271,
-0.023379367,
0.0057651843,
-0.021095863,
-0.01441794,
-0.0010828391,
0.008264427,
0.02252969,
0.009904036,
0.015811939,
0.024733538,
-0.032818735,
-0.0076138936,
-0.018029062,
0.028039308,
-0.027800336,
-0.0323939,
-0.0070961225,
0.013143426,
-0.026645308,
-0.0035181898,
-0.02106931,
-0.036031574,
0.010216027,
0.0003453883,
-0.010249217,
-0.0452718,
0.007959074,
-0.014683464,
0.0115701975,
-0.0027813613,
-0.031252146,
-0.01636954,
-0.005356942,
-0.0025954947,
-0.007653722,
0.0048789987,
-0.028490698,
0.016130568,
0.026353233,
0.011961845,
0.013037216,
-0.007992265,
0.004102342,
-0.021772947,
-0.0016520557,
-0.011995035,
-0.038261972,
0.00978455,
-0.017511291,
0.03252666,
0.025954947,
0.03990822,
-0.008616245,
0.027189633,
-0.00035389338,
0.021042757,
0.0019366639,
-0.00030721928,
0.01605091,
-0.024162661,
0.020392224,
-0.000992395,
-0.0115569215,
0.032712527,
-0.027189633,
0.0060937703,
0.032447003,
-0.013886892,
-0.0069235316,
0.019980662,
-0.009684979,
-0.027933098,
0.019104434,
-0.0067608985,
0.002197209,
-0.027534813,
-0.004460799,
0.0110192355,
0.032048717,
0.0073151793,
-0.0061203223,
0.0048358515,
-0.008881769,
0.02173312,
-0.022927975,
-0.005038313,
0.009864207,
-0.02671169,
0.010773626,
-0.025344241,
0.02336609,
-0.0032758992,
0.0022536328,
0.00445748,
0.0024096281,
0.005376856,
-0.004888956,
-0.006438951,
-0.009353074,
-0.014338283,
-0.011430797,
-0.015466759,
-0.033588756,
-0.013807235,
-0.011729511,
0.007932522,
-0.0015400378,
-0.012917731,
0.016515577,
-0.0014429557,
-0.017723711,
0.02295453,
-0.0025257948,
0.040306505,
-0.023910414,
0.0074877697,
0.0044873515,
0.008410465,
-0.009446007,
-0.011888826,
-0.019409787,
0.007514322,
0.028862432,
0.038713362,
-0.0020544901,
-0.028676566,
0.008802112,
0.015002092,
-0.0049752514,
-0.0220783,
0.03600502,
-0.000332527,
-0.004155447,
-0.01939651,
-0.010587759,
-0.028915538,
-0.0019549187,
-0.0016910544,
0.010999321,
-0.011165273,
-0.009764636,
-0.028464146,
0.043413132,
-0.007135951,
0.020299291,
-0.007003189,
-0.019794796,
-0.0055759987,
-0.029127955,
-0.008689265,
0.0015782068,
0.011470626,
0.036615726,
-0.007839588,
0.0036974184,
0.021839328,
-0.008138303,
-0.0053303894,
-0.0069832746,
0.009094189,
0.035473973,
0.007826312,
-0.007142589,
0.015174682,
-0.0013848724,
0.027216185,
-0.031039726,
-0.0074081128,
-0.006342699,
-0.02225089,
-0.021441042,
0.04628079,
0.0036376754,
-0.017710434,
0.01305713,
-0.033907384,
-0.0038003088,
-0.021879157,
-0.021361386,
0.016435921,
-0.059849054,
0.01991428,
0.0062663606,
0.013634644,
0.029420031,
0.021215348,
0.015068473,
-0.003604485,
0.028650014,
-0.027003765,
0.0103886165,
0.022343824,
0.02594167,
-0.026313404,
-0.014059483,
-0.008875132,
-0.01013637,
-0.00693017,
-0.02553011,
-0.02553011,
0.0035513802,
-0.0042284657,
0.028464146,
0.011271483,
-0.021095863,
0.03342944,
0.00651197,
0.023551958,
0.007574065,
-0.0046864944,
0.0212419,
-0.0022536328,
-0.020631196,
0.003667547,
-0.010561207,
-0.0037903516,
-0.0033140683,
-0.001563271,
0.022157958,
-0.009240227,
-0.0021706566,
-0.01898495,
-0.009060998,
-0.024388356,
-0.0035945277,
-0.0073616463,
-0.004384461,
-0.008470207,
0.009910674,
0.0024245637,
-0.0057685035,
-0.026698414,
0.00045056062,
0.011782616,
0.02409628,
-0.009452646,
0.004364547,
-0.0076802745,
-0.024587499,
-0.03937717,
0.015719006,
-0.015373825,
0.03937717,
-0.005104694,
-0.026193919,
-0.013196531,
0.0016653318,
-0.042882085,
-0.010036798,
0.0025473684,
0.0073749223,
-0.007016465,
-0.00532707,
-0.028915538,
0.011390969,
-0.0046333894,
0.025304414,
0.015692454,
-0.011324588,
0.01636954,
-0.008198046,
0.011384331,
-0.0032227945,
-0.029871423,
-0.019383233,
0.046254236,
0.0006003326,
-0.011935293,
0.02085689,
-0.009525665,
0.03688125,
-0.02667186,
0.007886056,
0.00022092406,
0.01737853,
0.02472026,
-0.013714301,
0.008928237,
-0.007275351,
0.008158217,
-0.020538263,
-0.0084038265,
0.013588178,
-0.009253503,
0.007839588,
-0.023312986,
-0.030535232,
0.021772947,
-0.023551958,
0.03958959,
0.008729094,
-0.0019648757,
-0.0021723162,
0.017750263,
0.000070218586,
-0.024587499,
-0.0051378845,
-0.02225089,
0.0195691,
-0.00866935,
0.0026369828,
-0.012008312,
0.003943028,
-0.0072487984,
-0.024892852,
-0.0067376653,
-0.0024195851,
-0.032154925,
-0.027481709,
0.016462473,
0.016807653,
-0.014909158,
-0.012658845,
0.0033356422,
-0.01939651,
-0.02399007,
0.0058182892,
-0.007567427,
-0.02089672,
-0.008709179,
-0.00036032402,
-0.010680693,
-0.009200398,
-0.004610156,
-0.00075134926,
0.003956304,
0.0063825273,
0.19627516,
-0.01748474,
-0.013010664,
-0.0122937495,
-0.011404245,
-0.0055461274,
0.010674055,
0.00863616,
0.0031215637,
-0.008290979,
0.00975136,
0.008058646,
-0.013349207,
0.009346436,
0.022768661,
-0.022264166,
-0.013727578,
-0.0047661513,
-0.028995194,
-0.0040791086,
0.012300388,
0.004603518,
0.008901684,
-0.0015889937,
0.03512879,
-0.0148162255,
-0.033004604,
-0.00031385737,
0.0051544798,
0.011364416,
-0.029473137,
0.014948987,
0.008855217,
-0.0057386323,
-0.00001627111,
-0.010474912,
-0.019715138,
0.000567557,
-0.000027252487,
0.008835303,
-0.0036476327,
-0.010003608,
-0.0237511,
0.015665902,
0.004444204,
0.003468404,
0.015400378,
-0.02023291,
-0.022463309,
-0.009970417,
-0.049546733,
-0.004407694,
0.0054631513,
0.030269708,
0.00014427482,
-0.008131665,
0.025729252,
0.018918568,
-0.018334415,
0.02229072,
-0.0066049034,
0.025463728,
-0.019170815,
0.03658917,
-0.0254239,
0.0396958,
-0.021719843,
-0.0067443033,
0.005446556,
0.0035049135,
0.010720521,
0.015559692,
-0.01344214,
0.0030535231,
-0.013296102,
-0.0063393796,
0.0070297415,
0.00651197,
0.009226951,
0.024494566,
0.02632668,
0.015997807,
-0.028251728,
-0.0077333795,
-0.0067476225,
-0.03958959,
0.026632033,
0.009392903,
-0.03019005,
-0.02218451,
0.022224339,
0.0017126282,
-0.018507006,
-0.019715138,
0.013435502,
-0.0033455994,
-0.0012272176,
-0.0044707563,
-0.018586664,
-0.0021075949,
-0.007567427,
0.067018196,
0.009465922,
0.007879417,
-0.0059311367,
0.005579318,
0.014630359,
-0.012519445,
-0.003677504,
-0.00060448144,
0.008961427,
-0.032022163,
0.011922017,
-0.011988398,
-0.0024013305,
0.007965713,
-0.005283923,
-0.001908452,
0.028888984,
-0.012426511,
0.0023432472,
-0.038315076,
0.01894512,
0.03791679,
-0.021945538,
0.01883891,
-0.026180642,
0.0054000895,
0.0067741745,
-0.02643289,
0.0013251295,
0.010401893,
0.02079051,
-0.00078868854,
0.013793959,
-0.02827828,
0.007355008,
-0.029021746,
-0.027800336,
0.029101403,
0.008290979,
-0.0069699986,
0.031172488,
-0.00057087606,
-0.012519445,
-0.014325007,
0.017962681,
0.0020909996,
-0.019343406,
-0.01883891,
0.012393321,
-0.028331384,
-0.015307444,
-0.021706566,
0.024056451,
-0.01748474,
-0.0044641183,
-0.017471462,
0.015971255,
-0.0011218379,
-0.02750826,
0.024733538,
0.0049022324,
-0.0068969796,
-0.008344084,
0.007779846,
-0.16600545,
0.017391806,
0.012784969,
-0.019343406,
0.028145518,
0.032208033,
-0.0084171025,
0.006090451,
-0.010089902,
0.009114102,
0.046307344,
-0.0070297415,
-0.044076942,
-0.021918986,
-0.010614312,
0.0103753405,
-0.013475331,
0.007501046,
0.02750826,
0.027587919,
0.037624717,
-0.032792185,
0.013375759,
-0.0053403466,
0.008125027,
0.016741272,
0.001959897,
-0.007633808,
-0.009897398,
-0.0020528305,
-0.012512807,
0.0012902794,
0.024122832,
0.00020401766,
0.012074693,
0.006296232,
-0.013468692,
-0.016329711,
0.019794796,
0.027003765,
0.03451809,
0.0051976275,
-0.002615409,
0.023074014,
-0.018998224,
0.035367765,
-0.016741272,
0.0006007475,
0.023857309,
-0.02280849,
0.04046582,
-0.007023103,
0.00849676,
0.018679596,
0.023140395,
0.0038500945,
0.012426511,
0.008111751,
0.01441794,
0.001643758,
-0.008018818,
-0.009738084,
0.025291137,
-0.016555406,
0.0019051329,
-0.029791765,
-0.025078718,
0.009990331,
-0.03196906,
-0.0022386971,
-0.023551958,
-0.014776397,
0.03488982,
-0.014006378,
0.022118129,
0.019104434,
-0.006053942,
-0.010886474,
0.008961427,
0.010713884,
0.004513904,
-0.005366899,
-0.029260717,
-0.0038633705,
-0.020471882,
0.0071824174,
0.00038127552,
0.011105531,
-0.004646666,
0.016396092,
0.015825216,
-0.02493268,
-0.0067575793,
0.0003684142,
0.025397347,
0.031172488,
-0.0027282566,
-0.002622047,
0.011477265,
0.015891597,
0.025888566,
-0.029127955,
-0.018812358,
-0.012492892,
0.030482126,
-0.02611426,
-0.02817207,
-0.0073815603,
0.056078617,
-0.023220053,
0.0096517885,
0.0059112227,
-0.0004766981,
0.011205102,
0.0010529676,
0.013369121,
0.014935711,
0.0034883183,
0.019383233,
-0.03130525,
0.07811709,
0.0067675365,
-0.011258207,
0.018161824,
-0.025344241,
-0.009718169,
-0.14338283,
-0.040837552,
0.008098475,
0.004815937,
-0.020113423,
-0.002393033,
-0.0060937703,
0.018135272,
-0.020325843,
0.016475748,
-0.026193919,
0.012877902,
-0.0010869879,
-0.019542549,
0.03263287,
0.01107234,
0.0046798564,
-0.012001674,
0.008629522,
0.031809747,
0.006601584,
-0.006521927,
-0.024003347,
-0.01636954,
0.012944283,
0.0076869125,
-0.043519344,
0.027242737,
0.008330808,
0.020631196,
-0.0049387417,
-0.007082846,
0.029181061,
-0.0007567427,
-0.045431115,
-0.0012637271,
0.0009102486,
-0.02353868,
0.02894209,
-0.009485836,
-0.010428445,
-0.0027332352,
0.005174394,
0.0076072556,
-0.022065023,
0.00074056233,
-0.023326261,
-0.0005853969,
0.022436757,
0.0060638986,
-0.02928727,
-0.036536068,
-0.03475706,
-0.0083905505,
0.021706566,
0.011271483,
0.0023731187,
0.033509098,
0.0026403018,
0.008410465,
0.010806817,
-0.0052274987,
-0.01654213,
-0.007919246,
0.026645308,
0.0076006176,
-0.0007135951,
-0.02336609,
0.013329293,
-0.017405082,
-0.004888956,
0.007826312,
-0.019343406,
0.01991428,
-0.013767406,
0.00543328,
-0.0017989235,
-0.009831017,
-0.0073948367,
-0.006166789,
-0.031145936,
-0.016502302,
0.01542693,
0.0065982654,
0.030322812,
-0.005645699,
0.0043313564,
0.016329711,
0.0063825273,
-0.018971672,
-0.007587341,
0.033455994,
0.014178968,
-0.024879575,
-0.023950243,
0.0030535231,
-0.015081749,
-0.0011990058,
0.04054548,
0.012134436,
-0.0006397463,
-0.0069036176,
-0.062185664,
0.019808073,
-0.019077882,
0.024773367,
0.0067376653,
-0.032951497,
0.020471882,
-0.02006032,
-0.0016661616,
0.0074744937,
-0.0064588655,
0.007501046,
-0.0032344111,
-0.0037140134,
-0.035686392,
-0.02817207,
0.023844033,
-0.018414073,
0.0044342466,
0.050874352,
-0.008523312,
-0.014218797,
0.023459023,
-0.0041089803,
-0.019701863,
-0.01072716,
-0.007461217,
0.012194178,
-0.014285178,
-0.0031530946,
0.010050074,
-0.040439267,
-0.031199042,
0.0035779325,
0.0011326248,
-0.020551538,
0.010023521,
0.03789024,
0.029632451,
0.033721518,
-0.022489863,
-0.047210123,
0.0103089595,
0.00068413856,
0.0024693708,
-0.013242997,
-0.028437594,
0.012625654,
0.024587499,
-0.020923272,
0.0215207,
0.006996551,
0.023047462,
-0.030694546,
0.0015624413,
-0.004321399,
-0.017298872,
-0.0028228494,
-0.00043272073,
-0.012619017,
0.006936808,
0.04171378,
0.013574902,
-0.00053934514,
0.022689005,
-0.004155447,
-0.017285597,
0.0048590847,
0.0068571507,
-0.012459702,
-0.0058348845,
-0.00070363795,
0.0011434116,
-0.00019831305,
0.013296102,
-0.0046499847,
-0.02827828,
0.019874454,
-0.04245725,
0.016316434,
0.013515159,
-0.016342986,
-0.011961845,
0.013979825,
0.043758314,
-0.0029174422,
0.001452083,
0.009134017,
-0.0019067924,
0.0016122271,
-0.010103179,
0.015825216,
0.022795213,
0.03534121,
0.0159447,
0.02476009,
-0.01877253,
0.017790092,
0.019794796,
0.030614888,
0.004537137,
0.00064970343,
0.02503889,
-0.010773626,
-0.0057784608,
0.017365253,
-0.022171233,
-0.021175519,
-0.024706986,
0.0012255581,
-0.0057452703,
0.004882318,
0.013156702,
-0.00063435285,
-0.02563632,
0.014909158,
-0.02795965,
0.01800251,
-0.008987979,
-0.0038102658,
0.00006311375,
0.011138721,
-0.010222664,
-0.0016752889,
0.026034605,
0.003913156,
0.024175938,
-0.015745558,
0.020936549,
-0.012731864,
0.012519445,
-0.00076213613,
-0.045006275,
-0.014617083,
-0.0096252365,
0.005393451,
0.004799342,
0.019821348,
-0.0065318844,
0.081622005,
0.020617919,
-0.01671472,
0.00473628,
-0.009353074,
0.01135114,
0.007886056,
0.019794796,
-0.015572968,
-0.03645641,
0.032367345,
-0.006575032,
0.0073948367,
-0.031836297,
-0.037040565,
0.025649594,
-0.0037472039,
-0.013276188,
0.017604224,
0.004593561,
0.004437566,
-0.023153672,
0.0058581177,
0.008085199,
-0.03305771,
0.0116365785,
0.018135272,
0.0109926835,
-0.0031331803,
-0.022994356,
0.013495245,
-0.025689423,
-0.0248663,
0.014338283,
0.025145099,
-0.014882606,
-0.039748907,
-0.023910414,
0.010189474,
0.028809328,
-0.00693017,
0.024906129,
-0.01469674,
-0.025330966,
0.02197209,
-0.016528854,
-0.016980244,
0.012041503,
-0.020803787
] |
Purpose We analyzed circulating tumor cells (CTC) in blood of metastatic breast cancer patients (n = 42) and determined the ability of this method to predict therapy response. Methods CTC from blood were analyzed before and during therapy for EpCAM, MUC1 and HER2 transcripts with the AdnaTest BreastCancer. The estrogen (ER) and progesterone (PR) receptor expression was assessed by RT-PCR. Results The overall detection rate for CTC was 52% (thereof 86% EpCAM; 86% MUC1; 32% HER2; 35% ER; | [
-0.03052861,
-0.0005802584,
0.0038094684,
-0.01340087,
0.01222466,
-6.162664e-7,
-0.021343596,
-0.008867835,
-0.044801727,
-0.0015652521,
-0.0018138752,
0.021224653,
-0.008312768,
-0.012555056,
-0.028995572,
0.022533022,
0.029577069,
0.00062692683,
-0.022810554,
0.0016139855,
-0.015964745,
0.0003997794,
-0.010374441,
0.0015066067,
-0.0017643158,
0.0075528575,
0.024105707,
-0.040704813,
-0.0042389836,
-0.025704825,
0.0011877744,
0.010552855,
-0.028599096,
-0.022044035,
-0.019955931,
-0.0028364514,
0.017074876,
0.0027389845,
0.041920673,
0.023616722,
0.00488656,
0.0043017585,
0.014207037,
-0.02148897,
-0.004790745,
-0.016229061,
0.015964745,
-0.002955394,
-0.01486783,
0.019361218,
-0.0034460325,
-0.016334789,
-0.008762107,
-0.0009854067,
-0.015872234,
0.002263214,
0.011127745,
0.030898655,
0.008596909,
-0.022044035,
-0.009383253,
-0.0031618918,
-0.03259028,
0.01782818,
0.0096277455,
0.0031139844,
0.0034328166,
0.020444918,
0.022321569,
0.012958139,
0.011550652,
0.02088104,
-0.007314972,
-0.0066839154,
0.011709242,
-0.009336997,
-0.019810557,
-0.008418496,
-0.0061420654,
-0.005596912,
0.023273109,
-0.008207042,
-0.005676207,
0.0041431687,
0.018171791,
0.010870036,
-0.004955943,
-0.00006334315,
0.017022014,
-0.000010499114,
0.025493372,
0.030132135,
-0.0037863406,
0.01206607,
0.011577084,
0.018700426,
-0.011378845,
0.04332155,
0.01703523,
-0.02865196,
0.008933914,
0.009356821,
-0.016321573,
-0.017207034,
-0.017114524,
-0.004113433,
0.006756603,
-0.004625547,
0.02078853,
-0.011530828,
-0.017920692,
0.025427293,
-0.021277517,
-0.011055057,
0.039779704,
0.011279726,
0.007242285,
-0.0003140829,
-0.014629944,
0.0052532996,
0.006964752,
0.0030925085,
0.038722437,
-0.011035234,
0.020101305,
0.01735241,
-0.026273107,
-0.007949333,
0.0065814927,
0.011636554,
-0.008187219,
-0.01496034,
0.024251083,
0.026814956,
-0.0013414086,
-0.010367833,
-0.025704825,
0.011649771,
-0.0080484515,
-0.025955927,
-0.00798898,
0.029550638,
0.020920688,
-0.00012751229,
-0.026537424,
0.013903073,
0.01862113,
0.003419601,
0.012786333,
0.009363429,
-0.015859019,
-0.030290725,
0.005081494,
-0.009621138,
-0.01807928,
-0.00040039892,
0.0061387615,
0.0094625475,
-0.018740073,
0.00033555867,
0.011114528,
0.015991177,
0.020035226,
0.0077841347,
0.035101295,
0.02833478,
0.016731264,
0.011616731,
0.012898669,
-0.024673989,
-0.0128788445,
0.00681277,
-0.028836982,
0.0014074879,
-0.0051310533,
0.014497786,
-0.01773567,
0.019281924,
-0.021158574,
-0.0468634,
-0.0042125518,
0.034466933,
0.016281925,
-0.03240526,
-0.008405279,
-0.009707041,
0.0065187174,
-0.008854618,
-0.007248893,
-0.03785019,
0.00093832525,
0.030317158,
0.017537432,
-0.004004402,
-0.6453563,
-0.026960332,
-0.0016139855,
0.004916296,
-0.00044107894,
0.015237873,
0.022242272,
-0.007169598,
-0.035180587,
0.008927306,
0.010744485,
0.010936115,
-0.008682813,
-0.0029933897,
-0.009700432,
-0.046440493,
-0.029392047,
0.0007458695,
0.016797343,
-0.0086365575,
-0.059999954,
-0.00748017,
-0.0074735624,
0.028942708,
-0.0063403035,
0.009257702,
0.020286327,
0.00036302285,
0.004447133,
0.03988543,
-0.017048445,
0.041947104,
0.011127745,
-0.0012398118,
0.040361203,
0.0010101864,
0.002263214,
-0.0010878296,
0.010077084,
0.045673974,
0.0034526405,
-0.015237873,
0.018488972,
0.008524222,
-0.025162976,
0.037770893,
-0.014894261,
-0.0031932795,
0.0009721909,
0.0037433892,
-0.010433912,
0.0060032993,
-0.03330394,
-0.010552855,
0.012112325,
0.002702641,
0.02537443,
-0.033277508,
-0.013519813,
-0.014616729,
0.012977963,
0.010870036,
-0.0055473526,
-0.027673988,
-0.010863427,
0.017550647,
-0.020550644,
0.0037698208,
0.00814757,
-0.006865633,
0.008669597,
0.025969142,
-0.0062874397,
0.009687217,
0.03163874,
0.025414078,
0.020180602,
-0.0045297323,
0.004440525,
0.01047356,
0.00980616,
-0.0043909657,
-0.021396458,
0.013361223,
-0.0043149744,
-0.011999991,
-0.020907473,
0.027779713,
0.023405267,
0.027409669,
-0.0037070455,
0.013328183,
-0.00076280226,
-0.022215841,
0.0068458095,
0.01550219,
-0.0067632105,
0.007572681,
0.022110114,
-0.035074864,
-0.033700414,
-0.034519795,
0.029471342,
-0.0080484515,
0.024621125,
-0.010268714,
-0.022942713,
0.009812768,
0.029867819,
-0.031665172,
0.0030776407,
-0.008207042,
0.009740081,
-0.01480175,
-0.007070479,
-0.01674448,
0.0036178385,
0.050246656,
-0.0014644812,
-0.016070472,
0.0019922892,
-0.00028310827,
0.0070506553,
0.0027290727,
0.015964745,
-0.009270918,
0.0096740015,
-0.01588545,
0.011616731,
-0.0076718,
-0.0018716946,
-0.013295144,
0.016083688,
-0.02218941,
0.011755497,
-0.003568279,
0.029709227,
-0.015555054,
-0.016110118,
-0.028123327,
-0.0056431675,
0.0067797303,
0.008887658,
0.0064129904,
0.0026811652,
-0.0106651895,
-0.005871141,
-0.0038094684,
-0.0052731237,
-0.003232927,
-0.0028083678,
-0.012422898,
0.012720254,
0.014590297,
0.011940519,
-0.011444924,
0.0029322663,
-0.019440513,
-0.0021013198,
-0.023709232,
-0.0046552825,
0.015832586,
0.007262109,
-0.0041299528,
-0.002608478,
-0.000015913223,
-0.0021260995,
0.026061654,
-0.010116732,
-0.038193803,
-0.009118935,
-0.011570475,
-0.0051046214,
0.011696026,
0.006224665,
0.00436123,
-0.024621125,
-0.022625532,
-0.0043248865,
-0.01273347,
0.0025093593,
-0.012991179,
-0.005230172,
-0.0033816053,
0.045991153,
0.013651972,
0.030792927,
-0.0015082587,
-0.0042984546,
0.018951528,
-0.019519808,
0.005137661,
-0.01843611,
0.010539639,
0.025110113,
-0.033859003,
0.019731263,
-0.0030842486,
0.0024135443,
0.027462533,
0.008960346,
0.019519808,
0.010321578,
0.003667398,
-0.0013761002,
-0.013691619,
-0.009145367,
-0.0070044,
0.033673983,
-0.006346911,
0.016718049,
-0.0034162968,
-0.015740076,
0.008174002,
-0.030502178,
0.0013554505,
0.0016205935,
-0.012363426,
0.0073215803,
-0.009621138,
-0.023286326,
0.009409684,
0.013453734,
0.00058604026,
-0.00576211,
0.011947127,
0.027621124,
0.008471359,
0.002529183,
-0.004252199,
-0.019374434,
0.033753276,
0.016916286,
0.018290734,
0.016162982,
-0.0056068236,
0.039726842,
0.01190748,
0.02524227,
0.015171794,
-0.0029207026,
0.017418489,
0.0064757657,
-0.016070472,
0.004463653,
-0.024105707,
0.009079288,
0.024819363,
0.01171585,
0.009766513,
-0.003935019,
0.011808361,
-0.016096903,
0.017008796,
0.0004020509,
-0.007942725,
-0.0026629935,
0.007698232,
0.056933876,
0.02492509,
0.035074864,
0.001219988,
0.009403076,
-0.012462545,
-0.010427305,
0.031321563,
0.027673988,
-0.023735665,
-0.0014091398,
0.010909683,
0.0089206975,
-0.007942725,
-0.010883251,
-0.020458134,
-0.0009920147,
0.027753282,
0.013770915,
-0.011312766,
0.022480158,
0.013546245,
-0.027700419,
-0.013493381,
0.026986763,
0.03615856,
-0.016625537,
-0.015806155,
0.0044041816,
-0.009052856,
-0.007262109,
-0.012660783,
0.0065847966,
0.018925095,
0.008662988,
0.004998895,
-0.009825983,
-0.007592505,
0.01706166,
0.005854621,
0.010017613,
0.024185004,
0.0021673993,
-0.009931711,
-0.009409684,
-0.017814964,
0.031189403,
0.010354618,
-0.019268706,
-0.029550638,
-0.02148897,
-0.010149771,
0.0071828137,
-0.010718053,
-0.005765414,
-0.0073480117,
0.0054449295,
0.024396457,
0.017616726,
0.009323781,
0.01432598,
0.016638754,
-0.017907474,
-0.018185008,
-0.011927303,
-0.009905279,
0.017722452,
0.033859003,
0.0051971325,
-0.001658589,
-0.015555054,
0.006707043,
-0.013156378,
-0.010988978,
0.0043182787,
-0.001566078,
-0.005841405,
-0.0040770895,
0.011808361,
-0.01674448,
0.0039614504,
0.010757701,
-0.023643153,
-0.019242276,
0.001747796,
-0.0005360679,
0.017748885,
-0.0066277483,
0.03504843,
0.026696013,
0.032801736,
-0.010374441,
0.018594699,
0.02772685,
0.016030824,
0.0029273105,
-0.006799554,
0.018977959,
0.0028992267,
0.0017048444,
-0.014140958,
-0.008629949,
0.017471353,
-0.007414091,
-0.00024366721,
-0.012145365,
-0.0010605719,
0.022995576,
0.0018419588,
-0.00023396182,
0.008405279,
-0.001393446,
0.030581474,
0.0025622225,
0.025453724,
-0.03721583,
0.027330374,
0.0020451525,
-0.021356812,
-0.0051938286,
0.004387662,
0.023801744,
0.006918497,
-0.018409677,
-0.0029471342,
0.0067731226,
-0.0043777497,
-0.008451535,
0.007341404,
-0.0029107907,
-0.014524218,
0.00331883,
-0.02336562,
-0.016863422,
-0.021145357,
0.0006698783,
-0.017524214,
-0.016718049,
-0.01929514,
0.0052632117,
0.004962551,
0.017682806,
0.0025836984,
-0.009416292,
0.004767617,
0.026563855,
-0.015832586,
-0.011028626,
0.01040748,
-0.038114507,
-0.009033033,
-0.01811893,
-0.008828186,
-0.0065881005,
-0.015436111,
0.018502189,
-0.0188458,
-0.025651962,
0.007493386,
-0.021462537,
0.0035286315,
0.019955931,
0.0033353497,
0.006029731,
-0.018330382,
-0.004384358,
0.0035583673,
-0.04033477,
-0.014643161,
-0.020524213,
-0.0132554965,
0.018859016,
-0.012555056,
-0.0029140946,
-0.011848008,
-0.0018799545,
0.025136543,
-0.010044045,
-0.005933916,
-0.0027274208,
0.010731269,
0.0114647485,
-0.024330378,
0.013295144,
0.015607917,
-0.0027075969,
0.002363985,
-0.0052962513,
0.035629928,
-0.017180603,
-0.016004393,
0.009766513,
-0.010539639,
-0.0033419577,
-0.010182811,
-0.008134355,
-0.0103810495,
0.031083675,
0.007314972,
-0.020828178,
-0.024766501,
-0.033568256,
-0.012356819,
0.00261013,
0.023088088,
-0.011088097,
-0.0436123,
0.018422892,
-0.012958139,
-0.02804403,
0.020140953,
-0.03333037,
0.0003915195,
0.032273103,
-0.01394272,
0.0019675095,
0.027198216,
0.02454183,
-0.027621124,
-0.014841398,
-0.01963875,
-0.04234358,
-0.010090301,
0.019030822,
0.036555037,
0.02725108,
0.027462533,
-0.0011035233,
0.013116729,
0.009991181,
0.011101313,
0.004549556,
-0.018264303,
0.01486783,
0.0059735635,
0.014444922,
-0.0035088079,
-0.014577081,
0.017775316,
-0.007301756,
0.011834793,
0.005772022,
-0.023894254,
0.005342507,
0.003829292,
-0.02833478,
-0.044484545,
0.002540747,
0.010770917,
0.026854604,
-0.043400846,
-0.0037169575,
0.011669594,
-0.0041696,
0.006905281,
-0.01254184,
0.024726853,
-0.024409672,
-0.013678404,
-0.009224663,
-0.011550652,
-0.00044809986,
-0.018251088,
-0.013823777,
-0.009720257,
0.015581486,
0.0024019806,
0.016017608,
0.015673997,
0.002022025,
-0.010784132,
0.00856387,
-0.018779721,
-0.022017604,
0.0021525314,
-0.01063215,
-0.01821144,
0.009925102,
-0.02266518,
-0.013162985,
0.0032725744,
0.011002194,
-0.018541835,
0.026286323,
-0.016348004,
-0.016427299,
0.03195592,
-0.0031850196,
0.013229065,
-0.015806155,
0.021779718,
0.0058513167,
-0.0050121103,
-0.00646255,
-0.024026413,
-0.015647564,
0.019625535,
0.037268694,
0.03237883,
0.01012334,
0.008002196,
0.013129946,
0.036211424,
-0.023471348,
-0.014524218,
0.006703739,
0.017801749,
-0.016083688,
-0.027832577,
-0.03864314,
-0.019348003,
0.0117951445,
-0.008610126,
-0.0038193802,
-0.004073785,
0.009819375,
-0.012376642,
0.035867814,
-0.011781929,
0.0047345776,
-0.0033700415,
-0.018396461,
-0.012951531,
-0.013638755,
0.0008363154,
-0.017220251,
-0.0037169575,
0.01868721,
-0.00872246,
0.0015090847,
0.021356812,
-0.02002201,
-0.010110124,
-0.0097929435,
-0.020101305,
0.038828164,
0.00577863,
0.0043116705,
0.0103810495,
-0.005861229,
0.02094712,
-0.013929504,
-0.0017230163,
-0.018330382,
-0.030079272,
-0.012469153,
0.03409689,
0.015145362,
-0.031242266,
-0.013955936,
-0.032220237,
0.020154169,
-0.044643138,
-0.011900872,
0.016229061,
-0.050088067,
-0.0151189305,
0.0142466845,
0.02180615,
0.048184983,
0.0035947107,
0.0037830367,
-0.010870036,
0.040361203,
-0.020867825,
0.021502186,
0.0030611209,
-0.007169598,
-0.023537427,
0.0125021925,
-0.009865631,
-0.031559445,
-0.0037334773,
-0.025810553,
-0.022942713,
-0.03269601,
-0.015251089,
0.006379951,
0.030845791,
-0.015105715,
0.0144581385,
0.025414078,
0.0053689387,
-0.014392059,
-0.0036541822,
0.015079283,
-0.023973549,
-0.0064394223,
0.016229061,
-0.015039636,
-0.0030297332,
-0.0010613978,
-0.007341404,
0.017246682,
-0.004873344,
-0.005487881,
-0.016136551,
0.035999972,
-0.019863421,
-0.0025853503,
-0.019440513,
-0.004810569,
-0.014022015,
0.018713642,
0.021356812,
-0.009165191,
-0.02374888,
-0.00509471,
-0.014894261,
0.013301752,
-0.011028626,
-0.00798898,
-0.02117179,
-0.022334784,
-0.013995584,
-0.014735671,
-0.015079283,
0.009429508,
0.00630396,
-0.009799552,
-0.044643138,
-0.0029107907,
-0.028229052,
-0.036528606,
-0.003657486,
0.02540086,
0.0023144255,
0.03021143,
-0.0066706995,
0.0033320459,
-0.0013463646,
0.016704833,
-0.020550644,
-0.025903063,
0.03724226,
-0.03097795,
0.019308355,
0.0075792894,
-0.039356798,
-0.027052842,
0.033039622,
0.0018683906,
-0.008762107,
0.024118925,
-0.01922906,
0.019519808,
-0.011352414,
-0.005560568,
-0.014140958,
0.009092504,
0.003578191,
-0.013116729,
-0.0011464749,
0.029259888,
-0.0010110125,
0.017920692,
-0.008649773,
0.009442723,
0.019044038,
0.0020435005,
-0.020431701,
-0.025347998,
0.008629949,
-0.017114524,
-0.0071101263,
0.031347994,
-0.008973561,
0.028229052,
0.020894257,
0.004470261,
-0.027462533,
-0.0069449283,
-0.0003818141,
0.0021393155,
0.00090280763,
-0.007975765,
-0.028493369,
-0.0014132698,
0.004305063,
-0.012601311,
0.0005162441,
0.0073744436,
-0.023312757,
-0.010552855,
0.007903078,
0.013394263,
-0.017590294,
-0.0039151954,
0.0012480717,
-0.012244483,
-0.02225549,
-0.01814536,
-0.012132149,
-0.015475758,
-0.018264303,
-0.009918494,
0.0018617826,
0.007982372,
0.0016569371,
-0.0027356807,
-0.0055473526,
-0.006386559,
0.19982363,
-0.0137048345,
-0.008028628,
0.030634336,
0.01893831,
-0.013955936,
-0.0033898652,
0.011233471,
0.018356813,
0.0058513167,
0.024977954,
-0.005834797,
-0.025665177,
-0.00024841665,
-0.0005129401,
0.00020907885,
-0.023696017,
-0.02193831,
-0.0070770867,
-0.00021331206,
-0.010242282,
0.007876646,
0.01929514,
-0.004879952,
0.026246674,
-0.017550647,
0.009112327,
-0.0027455925,
0.0317709,
-0.0112532955,
-0.039938293,
0.026986763,
0.013381046,
-0.0075792894,
0.0043017585,
0.0153303845,
-0.012270915,
0.003650878,
-0.012759902,
-0.02002201,
-0.023325972,
0.008768716,
-0.013288536,
0.014193822,
-0.002527531,
0.020101305,
0.005147573,
-0.023180598,
0.008491183,
-0.017550647,
-0.021766502,
0.012422898,
0.007889861,
0.010050653,
-0.009687217,
-0.009138759,
0.02187223,
-0.0037070455,
-0.022110114,
0.031136539,
-0.014140958,
-0.0036046228,
-0.030264294,
0.035709225,
-0.022929497,
0.024317162,
-0.021290733,
-0.015660781,
0.021607913,
-0.0015214746,
0.017973553,
-0.008081491,
0.0068524173,
0.0061552813,
-0.007433915,
-0.010400873,
0.020801745,
0.018872231,
0.012462545,
0.02406606,
0.019559456,
0.0013661884,
-0.019678399,
-0.019810557,
-0.023973549,
-0.023656368,
0.022810554,
0.021779718,
-0.019440513,
0.006631052,
0.011986774,
-0.016229061,
-0.016612321,
0.012277523,
0.019176196,
0.01862113,
-0.00085655216,
0.0012811113,
0.00011450294,
0.007843606,
-0.031083675,
0.07575324,
0.009270918,
0.017431704,
0.0018700425,
0.012555056,
-0.03037002,
0.0120065985,
-0.0019410778,
-0.0140088,
0.008676205,
-0.03473125,
0.015991177,
-0.008544046,
-0.0012431158,
0.022612317,
0.010605719,
-0.014577081,
0.0020368926,
-0.008286337,
-0.00888105,
-0.017682806,
-0.008504398,
0.032854598,
-0.0015231265,
0.0056332555,
-0.013638755,
-0.008398672,
0.01900439,
-0.012885452,
-0.009707041,
0.011213647,
-0.0006380777,
0.0058645327,
0.016929502,
-0.0043017585,
0.012178404,
-0.017259898,
-0.030237861,
0.015594701,
0.012350211,
0.005051758,
-0.01807928,
0.019810557,
0.00958149,
-0.021396458,
0.011696026,
0.017709237,
-0.032748874,
-0.013506597,
-0.010810564,
-0.009303957,
-0.02833478,
0.0046519786,
0.028599096,
-0.012673999,
-0.023167383,
-0.011603515,
-0.003132156,
0.0016883246,
-0.026524208,
-0.000872246,
0.019744478,
0.00046916262,
-0.0043017585,
0.016387653,
-0.16662543,
0.008378848,
0.013982368,
-0.022559453,
-0.0024052844,
0.009376644,
-0.00139675,
0.0014892609,
-0.014563865,
-0.009944926,
0.035286315,
0.009707041,
-0.025493372,
-0.008570477,
0.009224663,
0.00088711386,
-0.003419601,
0.035259884,
0.01977091,
0.01168281,
0.020259896,
-0.021145357,
0.010751093,
-0.018977959,
-0.011345806,
0.0047345776,
-0.008002196,
0.008134355,
-0.0042422875,
-0.014511001,
-0.008616733,
0.01470924,
0.024383241,
-0.0038061645,
-0.00026472996,
0.0039680586,
-0.009251094,
-0.01658589,
-0.002520923,
0.011788537,
0.01852862,
0.019136548,
0.0031222443,
-0.0116762025,
-0.0044041816,
0.035999972,
0.0012728514,
-0.0031437199,
0.015898665,
-0.011669594,
0.031083675,
-0.0016899767,
0.015938314,
0.0029917378,
0.0030363412,
0.014444922,
0.018290734,
0.015859019,
0.024872227,
0.004430613,
0.0112070395,
-0.021237869,
0.023167383,
0.0030776407,
-0.016427299,
-0.037189398,
-0.023722447,
0.028466938,
-0.024806147,
0.0041596885,
-0.025453724,
-0.024026413,
0.0029818257,
-0.033541825,
0.032986756,
0.015898665,
-0.020841394,
0.013599108,
0.024845796,
-0.009145367,
-0.0068458095,
0.013090298,
-0.023154167,
0.0026580375,
-0.00397797,
-0.017907474,
0.013063867,
0.02537443,
-0.016863422,
-0.02228192,
0.018673994,
-0.023669586,
0.01591188,
-0.025559451,
0.022149762,
0.013004395,
-0.01432598,
0.0021277517,
-0.011458141,
-0.0153436,
0.0306872,
-0.038563848,
-0.019836988,
0.00010841126,
0.01891188,
0.002532487,
-0.011854616,
-0.010552855,
0.044325955,
-0.012766509,
-0.033039622,
-0.008834795,
-0.003317178,
0.01394272,
0.010255499,
0.04173565,
0.010718053,
-0.006185017,
0.0059999954,
-0.019889852,
0.06311889,
0.0023738968,
-0.011147568,
0.02524227,
-0.0015297345,
-0.008325985,
-0.12962104,
-0.013850209,
0.024700422,
0.02546694,
-0.006482374,
0.028202621,
-0.0025721346,
0.020365622,
-0.031030813,
0.03613213,
-0.01744492,
-0.014074879,
-0.016110118,
-0.0050253263,
0.02562553,
0.000078365854,
0.00681277,
0.0059041805,
-0.0013537984,
0.029550638,
0.0075660734,
-0.0029421784,
0.010975762,
-0.015991177,
0.020867825,
-0.007222461,
-0.026682798,
0.013533029,
0.018422892,
0.03428191,
-0.007533034,
-0.0091321515,
0.019255491,
-0.014537433,
-0.013526421,
-0.0005587826,
-0.020828178,
-0.016797343,
0.033647552,
-0.006786338,
0.00057447643,
0.018977959,
-0.0050021987,
-0.0076321526,
-0.005339203,
-0.017616726,
-0.044325955,
-0.009409684,
0.0038854594,
-0.031506583,
-0.006132154,
-0.017074876,
-0.00081360067,
0.013823777,
0.0008590302,
-0.015621133,
0.027171785,
0.012290739,
-0.02804403,
-0.020273112,
-0.0030297332,
-0.0054713613,
-0.014643161,
0.014378843,
0.020127738,
-0.008134355,
-0.013030827,
-0.008438319,
0.016810559,
-0.0090858955,
0.0077973506,
-0.0020666283,
-0.017497784,
-0.024885442,
-0.026907468,
-0.0025077073,
0.021370027,
0.00087142,
0.0199295,
-0.022268705,
-0.015436111,
-0.019268706,
0.010367833,
-0.016162982,
0.01843611,
0.01378413,
-0.0025242271,
-0.019123333,
-0.0036376624,
-0.010486776,
-0.0012612876,
0.041180585,
0.0029306144,
-0.032828167,
-0.017973553,
0.014696023,
-0.009482372,
-0.0027588084,
0.021740071,
0.01432598,
-0.0147885345,
-0.022969145,
-0.061427265,
-0.0030859006,
0.0034691603,
-0.0041497764,
0.034361206,
-0.02645813,
0.0073215803,
0.009852415,
0.01798677,
0.0339383,
-0.008735676,
-0.0031883235,
-0.015806155,
0.028784119,
-0.015964745,
0.012693822,
0.011425101,
-0.001310021,
0.015290737,
0.04733917,
0.010011005,
-0.022044035,
0.0077444874,
-0.008610126,
-0.005448234,
-0.010242282,
-0.001838655,
0.028942708,
-0.024462536,
0.002178963,
0.0065319333,
-0.015052851,
-0.010308362,
-0.0008920698,
0.0018749986,
-0.0019394258,
-0.0037797326,
0.024118925,
0.0051872204,
0.0007789091,
-0.012455937,
-0.027700419,
0.004969159,
-0.00047453155,
-0.027436102,
-0.008378848,
-0.02148897,
0.0058248853,
-0.010077084,
0.019691614,
0.032114513,
-0.0029025308,
0.016414084,
-0.037295125,
-0.011187216,
-0.0024052844,
-0.0057059424,
-0.015938314,
-0.033859003,
-0.016004393,
0.035788517,
0.016030824,
-0.0007132428,
0.010268714,
0.009938318,
0.0062510963,
-0.020643156,
-0.0037962524,
0.0104999915,
-0.023960333,
-0.011425101,
-0.009317174,
0.008947129,
0.011808361,
-0.0022483463,
-0.027330374,
-0.019876637,
0.020867825,
0.0038689396,
0.016427299,
0.0006822682,
0.0065220213,
-0.01346695,
0.0069515365,
0.02085461,
0.005600216,
0.009726864,
0.012621135,
-0.0068854573,
0.010803957,
0.0096277455,
0.015079283,
0.027118921,
-0.0066640917,
0.0029818257,
0.019480161,
-0.015581486,
0.018872231,
0.007235677,
0.03581495,
-0.0009110676,
0.014022015,
0.009138759,
-0.028281916,
-0.013215848,
-0.0030726849,
-0.023722447,
-0.02521584,
-0.017048445,
0.016691618,
0.002178963,
0.00014196712,
0.011134353,
-0.004889864,
-0.0042389836,
-0.00856387,
0.0037433892,
0.0045958115,
-0.021449322,
0.023352405,
0.004288543,
0.007817174,
-0.0002007157,
0.024211435,
0.018819368,
0.0043116705,
0.02756826,
-0.0008437493,
0.017484568,
-0.0117951445,
0.0038160763,
-0.008081491,
-0.013863425,
-0.018713642,
0.011220256,
0.0121717965,
0.00054597977,
0.009436116,
-0.012621135,
0.09922459,
0.015740076,
-0.023682801,
0.0027935,
-0.022374433,
0.038510982,
0.029180594,
0.00032007133,
-0.0015751639,
-0.03208808,
0.0007078739,
-0.016506596,
0.013982368,
-0.05265194,
-0.023273109,
0.013288536,
-0.0062180567,
-0.0016858467,
-0.0010424,
-0.0078832535,
-0.011226864,
-0.036819354,
0.0011729066,
0.010480168,
-0.025004385,
0.002458148,
0.018383246,
0.014497786,
-0.019823773,
-0.01855505,
0.010116732,
-0.024938306,
-0.03644931,
-0.0048700403,
0.0010638759,
0.0017973554,
-0.025453724,
-0.045409657,
0.023484563,
0.005914092,
0.0038722437,
0.011035234,
-0.016480163,
-0.023392051,
-0.012693822,
-0.029762091,
-0.017590294,
-0.010969155,
-0.0066872193
] |
For rats access to a running wheel results in a pronounced but temporary suppression of feeding. The reasons for the feeding suppression and its temporary nature are unclear. The effects of alternate-day wheel access were explored by comparing feeding and running in 25 male Sprague-Dawley rats given either no wheel access, continuous wheel access, or alternate-day wheel access. With alternate-day wheel access food intake was suppressed on wheel days and elevated on non-wheel days for the full 32 days of the experiment. Body weight decreased on wheel days and showed a large increase on non-wheel days. Acquisition of running over days was similar in both wheel groups and plateaued | [
-0.008121047,
0.0031874941,
0.016963663,
-0.024410794,
-0.02315826,
-0.010095149,
0.0017145757,
-0.027324295,
-0.03270202,
-0.019005837,
-0.001911135,
0.0061979997,
0.0067187543,
0.015452454,
-0.016459927,
0.015792817,
0.045009527,
0.0014108022,
-0.00047565647,
-0.019700177,
-0.026112605,
-0.0023127627,
-0.030251412,
-0.035833355,
-0.020271985,
-0.017671617,
0.007290563,
-0.026139833,
-0.018243426,
-0.022137173,
0.023988744,
-0.0048944117,
0.0073314067,
-0.011238767,
-0.009618642,
0.0036282635,
0.002564631,
-0.03844734,
0.019114753,
-0.010197259,
0.009387195,
0.04198711,
-0.01459474,
0.014104619,
0.0020166473,
0.011218346,
0.016364625,
-0.009734365,
-0.0055717328,
0.02258645,
0.0065826094,
0.008195927,
-0.03218467,
0.0064600785,
0.011926299,
0.005350497,
0.0030036983,
0.007453937,
0.004673176,
-0.011572322,
0.008692856,
0.02016307,
-0.033954553,
0.014540283,
-0.008059782,
0.010469548,
0.010762259,
0.0010074727,
0.0061367345,
0.011368105,
0.020299215,
-0.0004107749,
-0.026303208,
-0.035751667,
0.02407043,
-0.006854899,
-0.0037235648,
0.0076105036,
0.01610595,
-0.006232036,
0.03360058,
-0.014975946,
-0.027623814,
0.024056816,
0.02491453,
0.002137476,
0.009387195,
0.023308018,
-0.0010661853,
0.005762336,
-0.020149454,
0.002382537,
0.019945238,
0.019686563,
0.026439352,
-0.0101768365,
-0.020176684,
0.028862733,
-0.020748492,
-0.018393185,
-0.01704535,
0.0036180525,
0.008488638,
-0.020026924,
-0.009019604,
-0.0016345906,
-0.0013614497,
-0.017780533,
0.00659282,
-0.034580823,
-0.024696697,
0.030088037,
0.00019145386,
-0.034771424,
0.0030496472,
-0.0044621513,
-0.0041626324,
0.0006458377,
-0.005874655,
-0.023512237,
0.020489817,
0.017372098,
0.046289288,
0.021088855,
0.0143632945,
0.025649711,
0.025690556,
0.0044383258,
-0.0042579337,
0.004826339,
-0.016977277,
0.005942728,
0.024819227,
0.0150031755,
-0.044192657,
0.027514897,
-0.008672435,
0.01157913,
-0.0072769485,
-0.011606359,
0.009829666,
0.012811242,
-0.015098477,
-0.024288263,
-0.009809245,
0.05331437,
0.020571504,
-0.0060652583,
-0.020544276,
-0.012491301,
0.0036078417,
-0.00005844661,
-0.005915499,
-0.0038052518,
0.025254892,
0.00329641,
0.017399328,
0.009863703,
-0.02070765,
-0.010537621,
0.010381054,
-0.03270202,
0.044192657,
-0.0035806126,
0.037521552,
0.018039208,
0.005711281,
-0.0025374019,
0.013934437,
-0.016759446,
-0.016786674,
-0.0021493887,
-0.028236466,
0.028345382,
-0.00006429659,
0.02149729,
0.0009930073,
0.01501679,
-0.02315826,
0.0043872716,
-0.029026108,
-0.0048399535,
0.011483828,
0.017658003,
0.013151604,
-0.034172386,
0.004417904,
-0.0075424314,
-0.011796962,
0.009074062,
-0.011245575,
0.008604362,
-0.044764467,
-0.015820045,
-0.6478322,
-0.004880797,
0.00659282,
-0.007998517,
0.014921488,
0.030687075,
0.005905288,
0.014935103,
-0.012232625,
0.023634767,
0.03112274,
0.0038529027,
0.00803936,
-0.017181495,
-0.008971954,
-0.012974615,
0.004312392,
0.0028692551,
0.012014793,
0.008897074,
-0.022314161,
0.025990075,
-0.026412124,
0.018338727,
0.022409461,
0.00045268203,
0.007984903,
-0.008141469,
-0.007133996,
0.014159077,
-0.00917617,
0.017426556,
-0.00006169069,
0.013246905,
0.05440353,
0.0061367345,
-0.014785344,
0.014962332,
0.011272803,
0.05470305,
-0.0133898575,
-0.0082163485,
0.027528513,
0.002699074,
-0.0072156833,
-0.008720085,
0.013158411,
0.0016958558,
0.00020889743,
-0.042341083,
0.016677758,
0.006565591,
-0.023103802,
-0.0016158706,
0.032919854,
0.0041694394,
0.029243939,
-0.017644389,
0.014880645,
0.009782016,
0.020476203,
0.018420415,
-0.00125849,
-0.0057010707,
-0.006637067,
0.0239479,
-0.003931186,
0.018951379,
0.007208876,
0.013519195,
0.02080295,
0.0059563424,
0.014567511,
0.013328592,
0.024873685,
-0.004928448,
0.03302877,
0.008345687,
-0.012879314,
0.004349832,
-0.037657697,
0.022082714,
-0.022436691,
0.014118233,
0.0034291514,
-0.027596585,
-0.020149454,
0.0104831625,
-0.011756118,
-0.010115571,
0.010864369,
0.015724745,
-0.010278945,
-0.026112605,
-0.025745014,
0.034771424,
0.026575498,
-0.0007921935,
0.012552566,
-0.020666806,
-0.02624875,
0.01701812,
-0.0006403068,
-0.002183425,
0.02951623,
0.012457265,
-0.012702325,
0.0052041416,
0.016936434,
-0.011967143,
0.030959366,
0.015547755,
0.007460744,
0.00094876025,
-0.0130767245,
-0.021524519,
0.027011162,
0.0009981128,
-0.027324295,
-0.041823734,
0.014295221,
-0.0027739538,
0.026983934,
-0.008740507,
-0.0000830697,
0.013444316,
-0.0029917858,
0.01419992,
-0.024410794,
-0.011878649,
0.010632922,
0.017304026,
0.03430853,
-0.018474871,
0.027936947,
0.018420415,
0.018978609,
0.0053028464,
0.012811242,
-0.026003689,
-0.015615827,
0.028590443,
-0.015997034,
-0.008502253,
0.017031735,
-0.018747162,
-0.0016065106,
0.008413759,
0.020326443,
-0.027596585,
0.0073790574,
-0.027297067,
-0.019536803,
-0.00038226953,
0.004411097,
-0.005650016,
0.0057589323,
-0.030714305,
-0.022286931,
-0.004285163,
0.005170105,
0.001385275,
-0.0061163125,
-0.00043077118,
-0.016990893,
-0.0038426917,
0.013995702,
-0.002736514,
-0.0386924,
-0.013280941,
-0.009993041,
-0.015139321,
-0.009741172,
0.035343233,
0.0045846817,
0.013049495,
-0.020394517,
0.0042511267,
-0.009169363,
0.0033168318,
0.0067017362,
-0.0058916733,
-0.0386924,
-0.0009793929,
0.0174674,
0.013968473,
0.029080566,
0.046153143,
-0.038583484,
0.033709493,
-0.0025697362,
-0.0007309283,
-0.014499439,
-0.00009960919,
-0.009686714,
-0.026221521,
0.011674431,
0.0049863094,
0.02068042,
0.031776235,
0.021973798,
-0.020094998,
0.0016371432,
-0.020094998,
0.020108612,
-0.0033440609,
0.013594075,
-0.008352494,
0.03112274,
0.0034308531,
0.003133036,
-0.0062830904,
-0.0023144644,
-0.019169211,
-0.021293074,
0.025799472,
-0.029625146,
-0.003893746,
-0.007195262,
0.005779354,
-0.00009503557,
-0.0039516077,
0.017140651,
-0.020871023,
-0.0064464645,
0.052252438,
-0.0035704018,
0.022055484,
-0.0024403986,
-0.028345382,
0.010312981,
0.013314978,
-0.027256222,
0.010408283,
0.011817384,
-0.000969182,
-0.01236877,
-0.011436177,
0.03109551,
0.027814416,
0.01801198,
0.016596071,
0.031258885,
-0.018692704,
-0.013798293,
0.0006990193,
0.013505581,
0.02283151,
-0.038038906,
-0.0075424314,
0.017372098,
0.0037610047,
-0.014227149,
-0.015139321,
-0.013022266,
-0.012545759,
0.020408131,
-0.0110822,
-0.0048229354,
0.014159077,
0.0054151663,
0.036350705,
0.008549904,
-0.022232473,
-0.02706562,
-0.022300545,
0.016010648,
-0.013219676,
0.020857409,
-0.01976825,
-0.038746856,
-0.013777871,
0.0023382897,
-0.020966325,
0.02842707,
0.006528151,
0.00494887,
0.0096731,
0.05328714,
0.028917192,
-0.016024264,
-0.01598342,
0.008311651,
0.010857562,
0.0070863455,
-0.019727405,
-0.006354566,
0.009809245,
0.013662147,
0.010374246,
0.011061778,
0.018270655,
-0.002988382,
0.0019911202,
-0.019400658,
0.014281607,
0.03087768,
0.003767812,
0.012076058,
-0.02703839,
0.015057634,
-0.015084863,
-0.008944725,
-0.016010648,
0.03327383,
-0.006810652,
-0.0056908596,
-0.04699724,
-0.006269476,
0.006194596,
0.0030292256,
-0.0073450212,
-0.001376766,
-0.010367439,
0.006912761,
0.009822859,
-0.026330438,
0.004237512,
0.0082367705,
-0.0130835315,
-0.006286494,
-0.008427373,
-0.0021868285,
0.015820045,
0.065894164,
0.019754635,
0.0038563062,
0.013301363,
-0.0035227512,
0.003730372,
-0.003560191,
-0.015098477,
0.014063776,
0.0064362534,
-0.0036214562,
-0.021075241,
0.012607024,
0.0030088038,
0.027828032,
0.0041081742,
-0.00838653,
-0.04598977,
0.017127037,
0.009380388,
0.01556137,
-0.008291229,
0.020571504,
0.035561066,
0.011402141,
0.0032232322,
0.00048501644,
0.034199618,
0.011824191,
-0.020911867,
0.023444163,
0.0036725106,
0.015874503,
0.028127551,
-0.004159229,
-0.018202582,
0.010912019,
0.005534293,
0.015588599,
-0.002464224,
0.017453784,
0.036377937,
0.0049692914,
-0.0040945597,
0.0012721046,
-0.0076377327,
0.014104619,
0.033437204,
-0.0031109126,
-0.020612348,
0.022450306,
-0.012770398,
0.007814721,
0.0286449,
0.028563214,
0.010081535,
0.0014414348,
-0.0032045122,
-0.027474055,
-0.01029256,
-0.017113423,
0.002852237,
0.013110761,
0.01680029,
-0.0049182368,
-0.014499439,
-0.00038780042,
-0.017031735,
-0.016786674,
-0.0027824629,
0.0055002565,
-0.0016167215,
0.0010534216,
0.021333916,
0.0039141676,
0.023226332,
0.01002027,
-0.023553079,
-0.008168698,
0.025540795,
-0.012892929,
-0.02125223,
-0.032919854,
-0.011837805,
-0.0031313342,
0.0032453556,
0.006892339,
-0.0051326654,
0.0025561217,
-0.00095982203,
0.005966553,
-0.011762925,
0.022150787,
-0.026330438,
0.0025322963,
-0.021211386,
0.00051777635,
0.017508242,
0.022082714,
-0.019359814,
0.022109943,
0.0018515716,
-0.014022931,
0.015697515,
-0.0073790574,
-0.006412428,
0.017998366,
0.0034665912,
0.01843403,
0.00024080642,
-0.0015733253,
0.008672435,
-0.029162252,
-0.0041694394,
-0.0037371793,
0.01731764,
0.019945238,
0.020489817,
0.011211538,
0.003866517,
-0.007875986,
-0.017372098,
0.035070945,
0.0026139833,
-0.026439352,
0.017603545,
-0.023934286,
-0.0049420623,
-0.046289288,
-0.00811424,
0.003177283,
0.029706832,
-0.0101564145,
-0.037984446,
-0.021551749,
-0.015343538,
-0.013886787,
-0.010775874,
-0.010442319,
-0.00035291328,
-0.037249263,
-0.007419901,
-0.0028913787,
-0.0041251928,
0.04144253,
-0.02285874,
0.0061163125,
0.007208876,
0.00043779117,
0.0101564145,
0.012572988,
-0.008134662,
-0.042123254,
0.016024264,
-0.00037333503,
-0.027746344,
0.018120896,
0.0012184975,
0.040489513,
0.040734574,
0.037957218,
-0.013280941,
0.011061778,
-0.002472733,
0.00018315752,
-0.015343538,
-0.014458596,
0.0029849785,
0.003968626,
0.029489,
0.013097146,
0.011381719,
0.013280941,
0.02894442,
0.0047140196,
0.048576526,
-0.005650016,
-0.015997034,
-0.008638398,
-0.042341083,
0.0098500885,
0.008420566,
0.008127854,
0.0040435055,
-0.028699359,
-0.02176958,
0.018760776,
0.02004054,
-0.014513054,
0.0069059534,
0.01689559,
-0.020299215,
0.026058147,
-0.00861117,
-0.0028182007,
-0.010530814,
-0.0072837556,
-0.010101956,
-0.0005828706,
0.017481014,
-0.009720751,
0.009959005,
0.005173509,
-0.01991801,
-0.004622122,
-0.013314978,
-0.028535984,
-0.009632257,
-0.007937252,
-0.010347018,
-0.037467096,
-0.018978609,
-0.022777053,
-0.0039516077,
-0.010680573,
-0.010265331,
-0.027365139,
0.0065315547,
-0.01635101,
-0.015207393,
-0.0028998877,
-0.018216196,
0.020176684,
0.020762108,
0.020979939,
0.026752487,
0.00018645478,
-0.020081382,
-0.010524006,
-0.001376766,
0.0030377347,
0.033437204,
-0.025132362,
-0.028808275,
-0.019128367,
-0.023444163,
-0.0050237495,
-0.011654009,
-0.057997756,
0.032593105,
0.0146900425,
-0.00039290587,
0.0068685138,
-0.013675762,
-0.0067459834,
0.011007321,
-0.01731764,
-0.009223822,
0.006565591,
-0.0021085453,
0.0061537526,
0.03354612,
-0.016174022,
0.033573348,
-0.009530148,
0.00432941,
-0.012239433,
-0.0058372156,
-0.023621151,
0.00006690249,
0.001086607,
0.023090187,
-0.008665627,
0.02179681,
0.004683387,
-0.0038869388,
-0.021007169,
-0.0026786523,
-0.034526363,
0.026303208,
0.0011368105,
0.00049522734,
-0.0009589711,
0.018325113,
-0.019305356,
-0.027405983,
-0.0040877527,
-0.0073586353,
-0.016432697,
0.009114905,
0.017766919,
0.022382233,
-0.020094998,
-0.013668954,
-0.009421232,
-0.016010648,
-0.01459474,
-0.030932136,
0.011048164,
-0.0064090244,
-0.017780533,
-0.010333403,
0.010925634,
0.00018379571,
-0.0044451333,
0.0052517923,
0.0039243787,
0.0101768365,
-0.050210264,
0.032892626,
-0.013056302,
0.025663326,
-0.02283151,
0.011715274,
-0.015112092,
-0.02340332,
-0.0060278187,
-0.0040366985,
-0.051299423,
-0.014703657,
0.008536289,
0.016174022,
-0.004792303,
0.02379814,
0.026126219,
0.009012797,
0.026357666,
-0.023961514,
-0.008073397,
0.010374246,
-0.034771424,
-0.009101291,
0.016432697,
-0.005660227,
0.007018273,
-0.015724745,
0.026425738,
0.004853568,
-0.015738359,
-0.0051122434,
-0.0211297,
0.002663336,
-0.026561882,
-0.024546938,
-0.024002358,
-0.013178833,
-0.01486703,
0.026126219,
-0.0028590444,
-0.02446525,
0.020816566,
-0.04223217,
-0.02110247,
-0.0047208266,
-0.007984903,
0.008400145,
0.0127499765,
-0.001865186,
-0.021429218,
-0.015602213,
-0.0076309256,
0.014894259,
0.00771942,
-0.0075424314,
-0.0041796505,
0.018842464,
-0.041551445,
0.0024489076,
0.028018635,
-0.0061026984,
0.033137687,
-0.01843403,
-0.0055615217,
0.015397996,
-0.0008606915,
0.014063776,
0.010619308,
0.0077942996,
0.011633587,
0.008121047,
0.0018583788,
-0.000011414107,
-0.013376243,
0.0037507939,
-0.01068738,
-0.027405983,
0.012675096,
-0.0077942996,
0.019781863,
0.0034648895,
-0.029026108,
0.0077738776,
0.02379814,
-0.012184975,
0.008624784,
-0.010367439,
-0.017943908,
0.021456446,
-0.0013563442,
-0.006997851,
-0.017235953,
0.00306156,
-0.0105035845,
-0.0062082107,
-0.024669468,
-0.01123196,
0.004717423,
-0.012899736,
0.0025884563,
0.019986082,
0.0076581542,
-0.00047012558,
-0.0065077296,
-0.017971136,
-0.019237284,
0.015874503,
-0.0041285963,
0.0066336636,
0.021864882,
-0.011933106,
-0.007835143,
-0.0014984455,
0.039155293,
0.0009453566,
0.008134662,
0.0067698085,
0.011177502,
-0.024410794,
0.02261368,
-0.0071748397,
0.012845278,
-0.015779201,
-0.0038426917,
-0.021633435,
0.010891598,
-0.008699664,
-0.0009453566,
-0.04299458,
-0.03703143,
0.0009734365,
-0.018719934,
0.017957522,
-0.009611835,
0.015139321,
-0.021279458,
0.017481014,
0.19060296,
-0.037821073,
0.014962332,
0.0146764275,
-0.0037576011,
-0.011388526,
0.01837957,
-0.005942728,
-0.0009130222,
0.019332586,
-0.0026344052,
0.014267992,
-0.022600064,
0.0043328134,
0.011892263,
-0.009482497,
-0.012906543,
-0.0075424314,
-0.011000513,
-0.008168698,
0.0071884543,
-0.0024114677,
-0.0060822763,
0.009080869,
0.050400868,
0.020544276,
-0.03517986,
-0.0038733243,
0.011810576,
-0.0019043278,
-0.009877318,
-0.012178168,
-0.03253865,
0.011565515,
0.008427373,
-0.0035567873,
0.0039652223,
-0.010299367,
0.007692191,
0.011089007,
-0.0023331845,
-0.0062830904,
0.005762336,
-0.0038699207,
-0.022695366,
0.013498774,
0.005262003,
-0.008325265,
-0.016691374,
-0.022926813,
-0.02080295,
0.01922367,
0.030088037,
0.020612348,
-0.000027494902,
-0.022382233,
0.03215744,
0.010789488,
0.010455933,
0.028835503,
-0.045554105,
0.012341541,
-0.013110761,
0.0032368465,
-0.020734878,
0.008638398,
-0.015520526,
0.019387044,
-0.013879979,
0.019400658,
0.011436177,
-0.020326443,
-0.026875017,
-0.012695518,
0.0001316777,
-0.000015382786,
0.015738359,
0.024778385,
0.013505581,
0.03651408,
-0.0030751745,
-0.0047412487,
-0.0012142429,
0.015643056,
-0.036377937,
-0.025050674,
0.03006081,
0.019686563,
0.006837881,
0.017181495,
-0.001946873,
-0.016827518,
-0.014921488,
-0.02016307,
0.00005722343,
-0.03169455,
0.016282938,
-0.007753456,
-0.0018856078,
-0.0032998137,
-0.028481528,
0.049338937,
-0.003298112,
0.0037882337,
-0.0063511627,
-0.000033211927,
0.0025408054,
0.036976974,
0.0114497915,
-0.012464072,
-0.005670438,
-0.031177199,
0.0030309274,
-0.018216196,
0.004428115,
-0.0050748037,
0.026902245,
-0.03188515,
-0.011211538,
-0.007828335,
-0.0017954118,
-0.019754635,
0.0104831625,
-0.0046051037,
-0.022804283,
-0.013049495,
-0.028127551,
0.006177578,
-0.00030866617,
-0.013852751,
-0.0053913407,
-0.004792303,
-0.025690556,
-0.007596889,
0.0020591926,
-0.002093229,
0.014022931,
-0.021524519,
-0.0025220856,
-0.006157156,
-0.0047957064,
-0.007399479,
0.009782016,
0.013451123,
0.030278642,
-0.018624632,
-0.008155083,
-0.0017937099,
-0.012464072,
-0.025554411,
0.0047786883,
-0.0038733243,
0.0031994067,
-0.013771064,
0.0025799472,
-0.016146794,
-0.027446825,
-0.050972678,
-0.015166549,
0.010741838,
-0.02867213,
-0.006422639,
0.0076105036,
-0.00013359226,
-0.0066404706,
0.00893111,
-0.17328532,
-0.003931186,
0.042967353,
-0.0030190146,
0.0015069547,
-0.0051224544,
0.030224184,
0.00038567316,
-0.027991405,
-0.00385971,
0.014485825,
-0.0068617063,
-0.025363807,
-0.007882793,
0.025391037,
0.012287083,
-0.01543884,
0.005650016,
0.004710616,
0.0025697362,
0.022055484,
-0.026575498,
0.02092548,
0.00280799,
-0.013008651,
0.008536289,
-0.005370919,
-0.0026395107,
0.021578977,
-0.03379118,
0.014635584,
0.023907056,
0.019972466,
-0.012293891,
0.0038086555,
-0.011551901,
-0.009496111,
-0.0057827574,
-0.012137324,
0.042586148,
0.015166549,
0.02627598,
-0.00031483523,
-0.014513054,
0.007133996,
0.023062957,
-0.000029196714,
-0.0011274505,
-0.0017937099,
-0.022436691,
0.0047991103,
-0.0067187543,
0.011810576,
0.015098477,
-0.0069842367,
0.001068738,
0.011688045,
0.009237436,
-0.012110095,
-0.029243939,
0.0041149817,
-0.014608355,
0.04332133,
-0.020517047,
-0.008604362,
-0.019141983,
-0.015084863,
0.013267327,
-0.014240764,
0.0039175716,
-0.013444316,
0.020271985,
0.0039039569,
-0.008774543,
0.00019092204,
0.019877166,
-0.0041285963,
-0.009816052,
0.02570417,
0.015574984,
-0.0036418778,
0.028236466,
-0.024887301,
-0.03193961,
-0.014485825,
0.012273469,
0.028100321,
0.035615522,
-0.012007986,
-0.015928961,
0.029461771,
-0.007229298,
-0.015166549,
-0.011225153,
0.011368105,
0.008495446,
0.01021768,
-0.010823525,
0.041306384,
-0.005067996,
0.012668289,
-0.019822707,
-0.02416573,
0.003740583,
0.020122226,
-0.010619308,
-0.0175627,
-0.0006896593,
0.029053336,
-0.005878059,
-0.009319123,
0.019863551,
-0.013158411,
-0.002183425,
0.0044315187,
0.032647565,
-0.007671769,
-0.0065894164,
0.018896922,
-0.020489817,
0.047432907,
-0.007161225,
-0.02503706,
0.006957008,
-0.004040102,
-0.016296552,
-0.1302635,
-0.038855772,
-0.0020268583,
0.004121789,
-0.017249567,
0.020544276,
-0.0037576011,
0.014036546,
-0.007065924,
0.012838471,
-0.00791683,
-0.010265331,
-0.0053402865,
0.0005713834,
0.018093666,
-0.010272138,
0.042313855,
-0.011313647,
-0.022300545,
0.025881158,
-0.0066336636,
-0.013682569,
-0.013478352,
-0.014989561,
-0.026698029,
0.0025220856,
-0.007835143,
0.015697515,
0.006286494,
-0.0002865426,
0.018052822,
0.007753456,
0.0055376966,
0.004666369,
0.0070250803,
-0.01543884,
0.00022038467,
-0.010891598,
0.0111570805,
-0.03379118,
-0.008965146,
0.015152935,
0.018175352,
0.008488638,
0.006439657,
-0.028481528,
-0.010823525,
0.03330106,
-0.0060652583,
-0.012845278,
-0.007481166,
-0.015888117,
-0.001367406,
-0.010605693,
0.025200434,
-0.010238102,
0.019536803,
-0.008985568,
0.0054934495,
0.024438022,
0.020598734,
0.0023502025,
-0.011599551,
0.013934437,
0.0005650016,
-0.003740583,
-0.022055484,
-0.0015341836,
0.005632998,
-0.015139321,
-0.0069263754,
-0.0028011827,
0.0059018843,
0.0073586353,
-0.01946873,
-0.010319789,
-0.005170105,
-0.029597916,
0.0014873837,
0.003241952,
-0.037984446,
-0.015397996,
0.024274647,
-0.02867213,
0.007317792,
-0.023226332,
0.007882793,
0.039427582,
-0.0030802798,
-0.010558043,
-0.020448973,
0.021429218,
0.01877439,
-0.028753817,
-0.029815748,
0.0058167935,
-0.00838653,
-0.005067996,
0.033409975,
-0.016936434,
-0.007950867,
-0.017276796,
-0.031231655,
0.020598734,
0.0020779127,
-0.0058814627,
-0.0028998877,
-0.012089673,
0.022109943,
-0.007399479,
-0.01586089,
-0.0041081742,
-0.032239128,
0.013131182,
-0.039318666,
-0.00009593966,
-0.015343538,
-0.033437204,
0.03836565,
-0.011041357,
0.0104967775,
-0.00020315382,
0.006834477,
0.026221521,
0.0074675516,
-0.011892263,
0.00073645916,
-0.0033644824,
-0.0068514957,
0.01835234,
0.002265112,
0.0030734728,
0.01447221,
-0.030442014,
0.013750642,
-0.0065349583,
-0.013172026,
0.0018447643,
-0.0048842006,
0.021810424,
-0.0010568253,
0.0020081382,
0.00017018121,
-0.006997851,
0.015057634,
-0.022205245,
0.030142495,
0.010864369,
0.0073858644,
0.0019809094,
-0.005796372,
0.011293225,
0.0051939306,
0.023634767,
0.019359814,
0.007365443,
-0.010673765,
-0.0001155105,
0.0057282997,
-0.02349862,
-0.0042511267,
-0.0019128368,
0.004765074,
-0.00061307783,
0.005687456,
-0.009822859,
-0.0028301135,
-0.022382233,
-0.014240764,
-0.014281607,
0.0033440609,
-0.016133178,
-0.027297067,
0.0005543653,
0.011334068,
-0.010660151,
0.01330817,
0.008257193,
-0.00087983685,
0.0033304463,
-0.016977277,
-0.007528817,
0.0027603393,
-0.012545759,
-0.037439868,
0.0010219382,
0.030414786,
-0.007556046,
-0.005224563,
0.012089673,
0.0013946351,
-0.0039243787,
-0.008338879,
0.017630773,
0.0034580822,
0.016636916,
0.011599551,
0.018788006,
-0.0071884543,
0.0069502005,
0.024478866,
0.027964177,
0.013097146,
0.002996891,
-0.020734878,
-0.0068072486,
-0.014785344,
0.017494628,
-0.010510392,
-0.021728737,
-0.008454602,
0.011279611,
0.0211297,
0.015248236,
-0.013907208,
0.0004884201,
0.0013214571,
0.0077670706,
0.004547242,
-0.0014363294,
-0.014513054,
-0.020476203,
0.014281607,
0.0013044389,
-0.008672435,
-0.009285087,
-0.007848757,
-0.015779201,
0.029352855,
-0.03087768,
0.012341541,
-0.008100626,
0.022654522,
-0.00052203087,
-0.049720142,
-0.031258885,
-0.013335399,
-0.012525337,
-0.00893111,
0.022545606,
-0.011946721,
0.060775112,
0.030768763,
-0.00608568,
0.016065106,
-0.00001348819,
0.0025969653,
0.0134102795,
0.0053402865,
-0.01810728,
-0.008447795,
-0.00764454,
-0.022872355,
0.0322119,
-0.024955373,
-0.025962844,
0.023308018,
0.0018753969,
0.007814721,
-0.005908692,
-0.019809093,
0.02706562,
-0.025145976,
0.032865394,
0.0069774296,
-0.025922002,
0.0018328517,
0.018502101,
-0.018869692,
-0.0032725846,
-0.0127499765,
-0.011708467,
0.045908082,
-0.029679604,
-0.014989561,
-0.00038631135,
-0.0058474266,
-0.015820045,
0.015888117,
0.017630773,
-0.014118233,
0.007419901,
-0.01029256,
-0.020571504,
0.012259854,
-0.020353673,
0.0031874941,
-0.012130517,
0.0030683673,
-0.012007986
] |
OBJECTIVE To evaluate the association between vascular inflammation as measured by subacute C-reactive protein (CRP; 1-10 mg/l) and all-cause mortality and the association between change in CRP status (normal <or=3 mg/l and elevated >3 mg/l) and all-cause mortality. METHODS Probabilistic record linkage was used to match hospital episode data, laboratory reports and mortality statistics in a large urban population. Survival was evaluated using Cox proportional hazards regression models. RESULTS 22 962 patients had their first CRP measurement in the subacute range (1-10 mg/l). Analysis grouped by each additional | [
-0.0008903953,
-0.007812501,
0.027704835,
-0.021126578,
-0.010740547,
0.01091124,
-0.026063554,
0.019301472,
-0.018251052,
-0.008436188,
-0.021047797,
0.003011752,
0.0017331934,
0.004352679,
0.0010126708,
0.009972427,
0.020509455,
-0.004428178,
0.0055212714,
-0.018461136,
-0.025315128,
0.023424372,
-0.011147585,
0.007346377,
-0.02016807,
0.0064994753,
-0.009007354,
-0.028965339,
0.016425947,
-0.038734246,
0.029070381,
-0.013333772,
-0.02644433,
0.018198531,
0.009243699,
-0.007300421,
-0.006414129,
0.011987922,
-0.0025603995,
-0.0104713775,
0.024159666,
-0.021152839,
0.022085086,
-0.017830884,
0.00017295005,
-0.01348477,
0.01917017,
-0.013799896,
-0.022623427,
0.030120801,
0.018474266,
-0.001526392,
-0.0040178574,
-0.0014246325,
0.019616598,
0.002383141,
0.014154413,
0.0311187,
-0.018513657,
-0.0115808835,
0.0006552817,
-0.0125328265,
-0.016412817,
-0.00851497,
-0.005751051,
-0.005350578,
-0.008403362,
0.03329832,
0.0011488972,
0.007195379,
0.036081936,
0.040099792,
-0.0005510603,
-0.006276261,
0.019879203,
-0.0027310927,
-0.020010507,
-0.007622112,
-0.0024734114,
0.020811452,
0.035582986,
-0.01141019,
-0.00040006242,
0.0035090602,
0.007352942,
-0.022702208,
-0.003577994,
0.016767334,
-0.016005779,
-0.0111607155,
0.010635505,
0.024501054,
0.009013919,
0.017331935,
-0.0131630795,
-0.0033055414,
0.0029362529,
0.02015494,
0.019971116,
-0.027652314,
-0.00045627632,
-0.024553575,
-0.009512869,
-0.012079833,
-0.023581935,
-0.0027048322,
-0.027757356,
-0.023279939,
0.016675422,
-0.0015657827,
-0.012014182,
0.047846645,
0.0093159145,
-0.01664916,
0.018579308,
-0.012920169,
0.018277314,
-0.002785255,
-0.011502102,
-0.03300946,
0.012355569,
0.0011177128,
0.046034668,
-0.017922796,
0.0096310405,
0.024330359,
-0.023542544,
0.007444854,
0.01034664,
-0.0005765002,
0.00065158884,
0.025315128,
0.008009454,
0.003180804,
-0.020102419,
0.020575108,
-0.02220326,
0.0035747115,
-0.020903364,
-0.021651788,
-0.00517332,
0.026221117,
-0.016373426,
0.0006552817,
-0.0016790312,
0.031775214,
0.030698532,
0.014810926,
0.004096639,
-0.007838761,
-0.02331933,
-0.021257881,
0.01295956,
0.0049468228,
-0.018946955,
0.00751707,
-0.003023241,
0.016281513,
-0.030882357,
-0.0141150225,
-0.016885506,
0.005708378,
-0.03264181,
0.010228467,
-0.019537818,
0.0010422139,
-0.0006117877,
-0.004812238,
-0.008587185,
-0.0013130254,
-0.008193278,
0.034926474,
-0.022465864,
0.017817754,
0.011429885,
0.0073135514,
0.0026194856,
0.01502101,
-0.020430675,
-0.04038866,
-0.024855569,
0.0016256896,
0.023542544,
0.007838761,
-0.012460611,
0.0049796486,
0.05280988,
-0.0016371785,
-0.00673582,
-0.013721115,
0.01450893,
0.006171219,
-0.0023437503,
-0.030777315,
-0.64075637,
-0.038629204,
-0.004204964,
0.008265494,
0.03734244,
0.036397062,
0.017909667,
0.0005087973,
-0.02752101,
0.028098742,
-0.01089811,
0.031355046,
-0.016977418,
-0.01551996,
0.0046513923,
-0.019065129,
-0.0134256845,
-0.0048450637,
-0.008436188,
-0.004224659,
-0.024041494,
0.007668068,
-0.023975844,
0.026890758,
-0.018474266,
0.02075893,
0.007149423,
-0.031223742,
-0.008718489,
0.031643912,
-0.007654938,
0.034296222,
0.005918462,
0.015336136,
0.050472695,
-0.03371849,
-0.00024762837,
-0.011206672,
0.008882617,
0.03353467,
-0.008383667,
-0.0115283625,
0.02124475,
-0.0026129205,
-0.02180935,
0.03051471,
0.004096639,
0.01348477,
-0.0060300687,
-0.0072085094,
0.005865941,
-0.0022452734,
-0.01970851,
-0.0040408354,
0.015730044,
-0.023463763,
0.006998425,
-0.007602417,
-0.010537028,
-0.0031266415,
-0.0073266816,
-0.018448006,
-0.008272059,
-0.00855436,
-0.0101037305,
0.032037817,
0.008895746,
0.0011702338,
0.0033252367,
0.0050617126,
0.021428574,
0.008409928,
0.014692754,
-0.017463237,
0.023135507,
0.006706277,
0.020627629,
0.009670432,
-0.026011033,
-0.01064207,
0.0101562515,
0.0055540972,
-0.007871587,
0.009112396,
0.013694854,
0.0051076687,
-0.034269962,
0.015585611,
0.00558364,
-0.008265494,
-0.008600316,
0.0027146798,
-0.006637343,
-0.012027312,
-0.027626052,
0.03159139,
-0.014771535,
0.015598741,
0.012388394,
-0.019222692,
-0.01859244,
-0.0074185934,
0.021126578,
0.026168596,
0.017056199,
0.0094734775,
-0.013799896,
0.006099003,
0.03059349,
-0.027547272,
-0.0023962713,
0.005215993,
0.005970983,
-0.027232146,
0.014548321,
-0.022229519,
0.008974528,
0.012027312,
-0.01162684,
-0.035346642,
0.021376053,
-0.008685662,
0.036081936,
0.011823793,
0.015953258,
0.0059447223,
-0.005797007,
-0.008587185,
0.013550421,
-0.032799374,
0.027179625,
0.00075622054,
0.030882357,
-0.012073268,
0.017791493,
-0.023686977,
0.018763132,
0.001987592,
-0.010504203,
-0.048476897,
-0.03167017,
-0.008212973,
0.014101892,
-0.01500788,
0.007412028,
-0.018040968,
-0.00095604657,
0.0095785195,
0.01814601,
0.030435927,
-0.004900867,
-0.015821956,
0.015940128,
0.006328782,
-0.02691702,
-0.0051897326,
0.010556724,
-0.011915705,
-0.01768645,
-0.005938157,
-0.012145485,
-0.0053276005,
-0.011344539,
-0.0029001448,
0.002353598,
0.007674633,
0.0036206674,
0.022400212,
-0.011502102,
-0.022702208,
-0.0050551477,
-0.007976629,
-0.011285453,
-0.0047236085,
0.0040014447,
0.015178573,
-0.029359248,
0.0030347297,
-0.0017200632,
-0.012998951,
0.0131630795,
-0.0077008936,
0.0006491269,
0.021559875,
0.01821166,
0.018106619,
-0.011042543,
0.0007168298,
0.0068802526,
0.032300424,
0.00802915,
0.030829836,
-0.034007356,
0.038996853,
0.0114758415,
-0.012263657,
-0.024133407,
-0.021441704,
0.008304886,
0.009204308,
0.02691702,
-0.008672533,
0.021152839,
-0.007766545,
0.00087972695,
-0.013399424,
0.000911732,
-0.006801471,
0.043723743,
0.005449055,
0.009722953,
0.0035812766,
0.0015116205,
-0.015690653,
-0.01446954,
0.01657038,
0.017883405,
-0.0039062505,
-0.00040190885,
-0.010983457,
-0.0018037686,
0.015428048,
0.030751053,
-0.016163342,
-0.02391019,
-0.0032251184,
0.00775998,
0.021310402,
-0.012335873,
-0.004346114,
-0.02482931,
-0.009020484,
0.030120801,
0.009401262,
0.0058068545,
0.024658617,
0.0074251583,
-0.021402312,
-0.001992516,
0.029595591,
-0.0030314473,
0.020955885,
0.0063648904,
-0.023608197,
-0.015454308,
-0.0127429105,
0.013721115,
0.023135507,
0.0024783353,
0.01702994,
0.011305148,
0.011114759,
0.0015140823,
0.0033432909,
-0.016281513,
0.0060169385,
-0.0024914655,
-0.00040929462,
0.028728995,
-0.0010750395,
0.047741603,
0.02481618,
0.004638262,
-0.009762343,
0.009978993,
-0.015191703,
-0.016741073,
-0.014915968,
0.0031709562,
0.0034992124,
-0.023056725,
-0.013865547,
-0.00019346608,
-0.033508405,
-0.002949383,
-0.008935138,
0.058245804,
0.0031102288,
0.013629203,
-0.0015107997,
0.0030412949,
-0.02282038,
0.017318804,
0.017397586,
-0.0009839484,
-0.033928573,
0.009571955,
0.0051142336,
0.0022863054,
0.03571429,
0.003326878,
0.017148111,
0.012519697,
-0.0007336529,
-0.0049468228,
0.0095259985,
0.03316702,
-0.02435662,
0.00052726176,
-0.0033088238,
-0.011219801,
-0.0056427266,
0.01970851,
-0.024724267,
0.013826157,
0.0050846906,
-0.017883405,
-0.014128152,
-0.013537291,
0.016215863,
0.00635176,
-0.0073792026,
-0.008088236,
0.014705884,
0.03329832,
0.021953784,
0.007897847,
0.010727417,
0.018487398,
-0.008974528,
-0.002102482,
-0.0072807255,
-0.0039029678,
-0.019393384,
0.021494225,
0.030409668,
0.013445379,
0.017240023,
0.01555935,
-0.0018743437,
-0.007884718,
-0.024855569,
0.026168596,
0.012007616,
0.0011620275,
0.005563945,
0.015769435,
0.014141283,
0.010136556,
0.017148111,
-0.0042345067,
-0.020286242,
0.005232406,
0.0065749744,
0.020561976,
-0.008534664,
0.032274164,
0.05745799,
0.011902574,
-0.018106619,
-0.012158615,
-0.0024783353,
0.02325368,
-0.016924897,
0.0025128024,
0.037526265,
-0.018001577,
0.0050091916,
-0.019747902,
-0.006959034,
0.016754203,
-0.006158089,
0.016911766,
0.0003666213,
0.0025308563,
0.024094015,
0.004720326,
0.019498426,
-0.0016987266,
-0.014561451,
-0.0024668463,
0.01709559,
0.010464812,
-0.034821432,
0.015940128,
0.013707984,
-0.022058826,
-0.028702734,
0.011193541,
-0.014850317,
0.0046809353,
-0.009204308,
-0.0054326425,
0.006959034,
-0.024396012,
-0.012841388,
0.033482146,
-0.0034335612,
-0.021664917,
-0.010589549,
-0.0413603,
-0.0069524692,
-0.013314077,
-0.006794906,
0.0013204111,
-0.0037125791,
-0.0006121981,
0.017581409,
0.01110163,
-0.014981619,
0.0101037305,
-0.010287554,
-0.006089155,
0.0044938293,
-0.021323532,
0.0062598484,
-0.0006536404,
-0.019511556,
0.006742385,
-0.025052523,
-0.013524161,
-0.014745275,
-0.0023043596,
0.0129333,
-0.012788867,
0.007050946,
0.0037618177,
0.00038959924,
0.009716388,
-0.0051831678,
0.009375001,
0.017043069,
-0.0075236354,
-0.009493173,
0.012985821,
-0.029674374,
-0.023030465,
-0.02593225,
0.007405463,
-0.006171219,
-0.029044122,
-0.013169644,
0.016951157,
-0.010149686,
0.007983194,
-0.03054097,
0.015756303,
0.014548321,
0.032983195,
0.012828258,
0.011232932,
0.0067226896,
0.040651266,
0.009946167,
-0.004707196,
0.026864499,
0.027626052,
-0.004963236,
-0.0093159145,
0.017240023,
-0.004818803,
-0.008396797,
-0.024514183,
0.0007332426,
-0.015743174,
0.014522061,
-0.0072479,
-0.011777838,
-0.022085086,
-0.023555676,
-0.0022584037,
0.02075893,
0.0033071826,
-0.005465468,
-0.023555676,
-0.005984113,
-0.029910717,
0.013077732,
0.03668593,
-0.02796744,
0.0016938027,
0.013891808,
-0.027941179,
-0.019485297,
-0.006794906,
-0.0045824586,
-0.021651788,
0.010707722,
-0.009978993,
-0.012184875,
0.007549896,
0.021047797,
0.055199586,
-0.00036539033,
0.038497902,
0.0026112793,
0.0022534798,
0.013944329,
0.013405989,
0.0026720066,
-0.005150342,
-0.005593488,
-0.007556461,
0.024986872,
0.028755255,
0.0025128024,
-0.013123688,
-0.035294123,
0.0020893516,
0.03508404,
-0.03771009,
-0.0014238119,
-0.014863447,
-0.034637608,
-0.006525736,
0.019419644,
0.003390888,
0.0030248822,
-0.03881303,
-0.018579308,
0.011659665,
-0.0032119881,
0.010799633,
-0.014850317,
0.026641285,
-0.03059349,
0.005613183,
-0.011613709,
0.0103663355,
0.015296745,
0.00042632292,
-0.0056722695,
0.016268384,
0.013839287,
0.0019941572,
0.023883931,
0.005885636,
0.012939865,
-0.017778363,
-0.012132354,
-0.026431201,
-0.012257092,
0.01450893,
-0.014666493,
0.027337188,
-0.0029986217,
-0.012710085,
-0.016478468,
0.00400801,
-0.0013614432,
0.008600316,
0.011324843,
-0.03839286,
-0.02851891,
0.022216389,
-0.018802524,
0.027599793,
-0.037473742,
0.033849794,
0.0019498427,
-0.002465205,
-0.007392333,
-0.0018727024,
0.009624476,
0.0024602811,
0.0055869226,
0.034269962,
-0.03728992,
0.0021779807,
-0.012578783,
0.026693806,
-0.014640233,
-0.04451156,
0.031302523,
0.0021353075,
0.0061876317,
-0.015086661,
-0.023279939,
-0.046717443,
0.022951683,
-0.0016700041,
-0.014154413,
0.03668593,
-0.0144958,
-0.019091388,
0.048923325,
-0.024028365,
0.027100842,
0.011193541,
-0.020509455,
-0.021861872,
-0.0066570383,
-0.023017334,
0.0049205623,
0.029805675,
0.034007356,
0.010701156,
0.0010635505,
-0.012073268,
0.0066340608,
-0.002406119,
0.009276524,
-0.02179622,
0.035582986,
0.021704309,
-0.008042281,
0.033613447,
0.017003678,
-0.013511031,
-0.017213762,
-0.011679361,
-0.029070381,
-0.029963238,
0.0051306468,
0.03371849,
0.019025737,
-0.028755255,
0.0018809089,
-0.021691179,
0.0024865416,
-0.013734245,
-0.011567754,
0.0066800164,
-0.023713239,
-0.012723216,
-0.004625132,
-0.013931199,
0.021034665,
0.017003678,
-0.002102482,
-0.0052094283,
-0.003653493,
-0.048266813,
0.030304626,
0.003011752,
0.0072085094,
-0.019051997,
0.017673321,
-0.0436187,
-0.014456409,
0.012966125,
0.011049109,
-0.050026264,
-0.023279939,
0.008442753,
0.025288869,
0.0012974332,
-0.0040703784,
0.031775214,
0.009900211,
-0.015073531,
-0.00045914855,
-0.0000074562913,
0.02434349,
-0.01717437,
0.012394959,
0.02182248,
-0.009657301,
0.014259455,
0.006853992,
0.014548321,
0.0076418077,
0.010944067,
-0.015506829,
0.0014812567,
0.03219538,
-0.011961661,
-0.018461136,
-0.01860557,
-0.0051897326,
-0.015073531,
0.0012317819,
0.015716914,
-0.022137607,
-0.0126903895,
0.011935401,
-0.024789918,
0.0006277902,
0.0038701422,
-0.005284927,
-0.0052816444,
-0.012257092,
-0.007293856,
0.00020772472,
-0.021074057,
0.018539919,
0.02124475,
-0.01809349,
-0.026759457,
-0.0023962713,
-0.044117652,
-0.013918068,
-0.016294645,
0.021415444,
0.007563026,
0.013537291,
-0.0011177128,
0.0433561,
-0.012440915,
0.020732671,
-0.02182248,
-0.017962188,
0.0069196434,
-0.0019843096,
0.021100318,
0.014692754,
-0.013281251,
-0.012893909,
0.03566177,
0.0065684095,
-0.005412947,
0.027626052,
-0.015808824,
0.007924108,
-0.022899162,
0.0029756436,
-0.0023979126,
-0.0065224534,
-0.012893909,
-0.019997375,
-0.0027458642,
0.011383929,
-0.0018300291,
0.0025472692,
-0.0037782304,
0.0048384983,
0.005426077,
-0.009375001,
-0.026601894,
-0.033245802,
0.0047039133,
-0.009224003,
0.023897061,
0.021704309,
-0.0011833641,
0.023174897,
0.014745275,
0.0054162294,
0.006450237,
-0.002545628,
-0.012224266,
-0.0024799765,
0.0009100907,
-0.010701156,
-0.013254991,
0.0055147065,
0.0143251065,
-0.0046185665,
-0.014338236,
-0.019485297,
-0.0069130785,
-0.013537291,
0.0036272325,
0.011305148,
-0.007608982,
0.022702208,
-0.0007492451,
-0.025039393,
0.0013097428,
-0.0094209565,
-0.004772847,
-0.002622768,
-0.02272847,
-0.0023109247,
0.009414392,
-0.0046218494,
0.0030741205,
-0.025157565,
-0.017581409,
0.0342437,
0.19380254,
0.0020877102,
-0.0072150743,
0.016609771,
0.0033186716,
-0.015926998,
-0.00801602,
-0.0065552793,
-0.0009839484,
0.017738972,
0.020627629,
0.0127429105,
-0.0039128154,
0.007779675,
0.01347164,
-0.023437502,
-0.0217437,
-0.029569332,
-0.019984245,
-0.026234247,
0.0019137345,
0.0010126708,
-0.004900867,
-0.008803835,
0.020023637,
-0.008212973,
0.01446954,
-0.0030314473,
0.034033615,
0.01814601,
-0.012998951,
0.0062401528,
-0.012368699,
0.019065129,
0.00066225714,
-0.00037749478,
0.012138919,
-0.006853992,
0.002127101,
-0.00674895,
0.0013737527,
-0.0055048587,
-0.017935926,
-0.02120536,
0.018237922,
0.015940128,
0.00010488816,
-0.0025571168,
-0.028755255,
0.016688552,
-0.031355046,
0.002424173,
0.00036108197,
0.004014575,
0.012788867,
0.0011234573,
0.026011033,
0.0012522979,
-0.007937239,
-0.0015107997,
0.007287291,
-0.021481095,
-0.02229517,
0.01867122,
-0.03300946,
0.015940128,
-0.01865809,
-0.021139707,
-0.024606096,
-0.013379728,
0.03209034,
-0.017371325,
-0.011449581,
-0.0026063554,
-0.011869749,
0.0017118568,
0.0044248956,
0.044826686,
-0.0012112659,
0.023752628,
0.006959034,
-0.0093159145,
-0.027757356,
0.0023273374,
-0.018723741,
-0.031407565,
0.01399685,
0.030147063,
-0.029096643,
-0.0044610035,
0.015244224,
-0.020601368,
-0.028256305,
-0.005842963,
0.024711138,
0.005038735,
-0.0074842446,
-0.0023552391,
0.00043165707,
0.0039883144,
-0.0055770753,
0.07195379,
0.013734245,
0.011193541,
-0.0042279414,
-0.0048811715,
-0.029359248,
0.009276524,
-0.001016774,
-0.013261556,
-0.009972427,
-0.010129991,
0.007950368,
-0.009519434,
0.00099872,
0.016727943,
0.0018891152,
-0.004999344,
0.012631304,
0.0133731635,
-0.009978993,
-0.013734245,
0.0020023636,
0.017476367,
0.0030577078,
-0.007930673,
-0.019800423,
0.0020433958,
-0.020378154,
-0.04711135,
0.019564077,
-0.0066406257,
0.009184612,
-0.015480569,
0.0055442494,
0.004549633,
-0.007661503,
-0.02338498,
0.0125328265,
0.029831937,
0.007412028,
-0.011639969,
-0.0059283096,
-0.0047695646,
0.014351367,
0.028413868,
0.012184875,
0.02377889,
-0.03274685,
0.0112657575,
0.00012186517,
-0.009959297,
-0.018054098,
-0.0007755056,
0.004608719,
-0.03521534,
-0.030803574,
-0.042148113,
0.02278099,
-0.013970589,
-0.04196429,
0.0160583,
0.026286768,
-0.01865809,
-0.00699186,
0.011981356,
-0.1647059,
0.020365024,
0.006053047,
0.0012375264,
0.011731882,
-0.0052750795,
-0.00028127464,
0.007943803,
-0.018172272,
-0.012414655,
0.036528364,
-0.007851891,
-0.014719014,
-0.013760505,
0.004999344,
-0.010189077,
0.013353468,
0.053755257,
0.015336136,
0.02282038,
0.035294123,
-0.015730044,
0.021520486,
-0.023188028,
0.001343389,
-0.022649687,
-0.012847953,
0.019157039,
-0.00006965189,
-0.008659402,
-0.025577733,
-0.0050518652,
0.042095594,
-0.0029099924,
-0.025761558,
0.0027770486,
-0.017935926,
-0.0130055165,
0.011718751,
0.016754203,
0.023923323,
0.004749869,
0.0036108198,
0.01813288,
-0.03939076,
0.029411769,
0.016846115,
-0.009716388,
0.024146536,
-0.013038342,
0.007116597,
-0.011200106,
0.010635505,
0.0059873955,
0.0011013,
0.021349791,
0.010136556,
0.0034040182,
0.009611346,
0.003479517,
-0.0022108064,
-0.019222692,
0.025695905,
0.018828783,
0.014246325,
-0.017962188,
-0.0014443279,
0.014797796,
-0.002901786,
0.008442753,
-0.030803574,
-0.015414918,
-0.0017775081,
-0.026299898,
0.035871852,
0.022570906,
-0.017712712,
0.012670695,
0.005393252,
0.001640461,
0.016885506,
0.01089811,
-0.017581409,
-0.010294119,
-0.014889708,
0.007851891,
0.019104518,
0.02229517,
0.011981356,
-0.0140099805,
0.0017857144,
-0.03773635,
0.019485297,
-0.0035976896,
-0.0045758933,
0.018054098,
-0.0029149163,
0.025380779,
-0.012335873,
0.00387999,
0.01972164,
-0.01760767,
-0.020365024,
-0.0050649955,
0.008390232,
-0.020378154,
0.0034171485,
-0.013931199,
0.021310402,
-0.023476893,
-0.012020747,
0.01139706,
0.0041787033,
0.015099792,
-0.008508404,
-0.01709559,
-0.019761031,
-0.0076483726,
-0.017253153,
-0.046271015,
0.05803572,
-0.0032595855,
-0.005110951,
-0.0069787297,
-0.008370536,
-0.004644827,
-0.12710086,
-0.0010126708,
0.00311187,
-0.004142595,
0.00005872711,
0.0124803055,
-0.027573531,
-0.004099922,
-0.006420694,
0.026851369,
-0.026207985,
-0.0047991076,
-0.01500788,
-0.0125328265,
0.041832987,
0.008613446,
0.0058757886,
-0.030147063,
-0.00033707824,
0.0404937,
0.016373426,
-0.019774161,
-0.0010274423,
-0.017148111,
0.0051897326,
-0.006381303,
-0.010747112,
-0.0059283096,
-0.0009174765,
0.03167017,
0.011239497,
0.00005816292,
0.020063028,
-0.009493173,
-0.026076684,
-0.025538342,
-0.017016808,
-0.044432778,
0.0160583,
-0.012342438,
0.0045463503,
0.012033877,
0.0351103,
-0.03642332,
-0.004667805,
0.036580887,
-0.036738448,
-0.0030265234,
-0.00986082,
-0.028650213,
-0.002302718,
-0.030882357,
0.0066570383,
0.005133929,
0.008042281,
-0.011416756,
0.011534927,
0.017463237,
-0.02077206,
-0.007714024,
-0.02282038,
0.011856619,
-0.038051475,
0.027573531,
0.018750003,
-0.029700633,
0.0035517334,
-0.0269958,
0.0020795038,
-0.002832852,
-0.023542544,
-0.0034663868,
-0.021586137,
-0.008987659,
-0.005005909,
0.021546746,
0.0069262087,
-0.001999081,
-0.0025275738,
-0.009099266,
-0.006404281,
-0.008895746,
-0.0040703784,
-0.021980044,
-0.009447217,
0.024107145,
0.013602942,
-0.010221902,
0.0066209305,
-0.013123688,
0.003011752,
0.02591912,
0.030777315,
0.00051084894,
0.004959953,
0.0014131435,
0.0025242912,
-0.029910717,
-0.021192228,
-0.003315389,
-0.0176208,
-0.015270485,
-0.0424895,
0.014403888,
0.010917806,
0.000344464,
-0.0015501905,
-0.03471639,
0.022584036,
-0.010701156,
-0.0055442494,
0.011443016,
-0.036029417,
0.015047271,
-0.011797532,
0.0144301485,
-0.021034665,
-0.010747112,
0.027809877,
0.031512607,
0.038051475,
0.004697348,
-0.012618174,
0.004963236,
-0.0040933564,
0.0201812,
0.001345851,
-0.00027573534,
0.019288342,
0.0067686457,
-0.013589812,
-0.009650736,
0.0114233205,
-0.025000002,
-0.006509323,
0.005150342,
-0.001987592,
-0.017305674,
-0.0024504336,
0.022387082,
0.01917017,
0.00199744,
-0.013707984,
-0.023214288,
0.019248951,
-0.006158089,
-0.003676471,
-0.014824056,
-0.023555676,
0.028282566,
0.0006745668,
-0.0053801215,
0.026483722,
-0.00798976,
-0.009486608,
-0.027415968,
-0.03718488,
0.028886558,
-0.006233588,
0.0023224135,
0.022610296,
-0.017909667,
0.031880256,
0.013576682,
0.0024159667,
0.0066110827,
0.03103992,
-0.0076811984,
-0.0054687504,
-0.004877889,
0.0059873955,
-0.01965599,
-0.021953784,
0.0003893941,
-0.0031972167,
0.013353468,
0.016281513,
-0.010070904,
-0.003326878,
0.009900211,
-0.019038867,
-0.0036206674,
0.0042968756,
0.017279414,
-0.020863973,
0.028781516,
0.011134455,
-0.0017922795,
-0.012893909,
0.019235821,
-0.006959034,
0.0068671224,
-0.014810926,
0.01754202,
-0.0010348281,
-0.016018908,
0.024225317,
0.022597166,
0.0067555155,
0.020535717,
0.017647061,
0.026286768,
-0.0048319334,
0.01217831,
-0.01503414,
-0.038839288,
0.005389969,
-0.0021861873,
-0.015835086,
-0.04613971,
-0.023805149,
0.004835216,
0.02383141,
0.010405726,
0.0071100323,
-0.0005046941,
-0.0043658093,
-0.012473741,
-0.008528099,
0.021074057,
-0.0068671224,
0.023634456,
-0.0134979,
0.009696692,
-0.0143776275,
0.0144301485,
0.0036731884,
0.025656516,
0.008134192,
-0.0059447223,
0.012145485,
-0.013235295,
0.014666493,
-0.034978997,
-0.030330885,
0.004608719,
-0.0037913607,
-0.031801473,
0.00904018,
0.0228729,
-0.00044848022,
0.07867648,
0.0000752938,
-0.009755778,
0.00066061586,
-0.0072413348,
0.015217964,
0.016767334,
0.01345851,
0.002540704,
-0.049579836,
0.014876577,
-0.0031200764,
0.014797796,
-0.055094544,
-0.022478994,
0.011620275,
0.00006919028,
0.024960611,
-0.006473215,
-0.028623952,
0.005783877,
-0.010477942,
0.01318934,
0.017844014,
-0.017962188,
-0.002563682,
0.044380255,
-0.015257355,
0.008482143,
-0.03434874,
-0.0003315389,
-0.0074711144,
-0.033061977,
-0.019393384,
0.014732145,
-0.021441704,
-0.011679361,
-0.016885506,
0.009138657,
0.00798976,
-0.012243961,
0.0035714288,
-0.011817228,
-0.015428048,
-0.0030659141,
-0.031013658,
-0.025157565,
-0.020365024,
-0.00044437702
] |
Despite the success of safe sleep campaigns and the progress in understanding risk factors, the rate of reduction in the cases of sudden infant death syndrome has now slowed and it remains a leading cause of postneonatal mortality in many developed countries. Strategic action is needed to tackle this problem and it is now vital to identify how the sudden infant death research community may best target its efforts. The Global Action and Prioritization of Sudden Infant Death Project was an international consensus process that aimed to define and direct future research by investigating the priorities of expert and lay members of the sudden unexpected infant death (SUID) community across countries. The aim was to | [
-0.004376366,
0.0013023703,
0.0009820056,
-0.038838573,
-0.021975512,
0.015096455,
-0.026686464,
0.0070664254,
-0.019994773,
-0.012105268,
0.022296714,
0.009428592,
0.010325279,
0.016461559,
0.0016536841,
0.023006033,
0.039641578,
-0.0051592938,
0.0230328,
-0.0011635177,
-0.023889337,
0.0013107349,
-0.017759748,
0.014146234,
-0.0002931797,
0.014828787,
0.01789358,
-0.028426303,
-0.007641911,
-0.006062672,
-0.010084378,
-0.025187524,
-0.0016018235,
-0.007180184,
-0.006149664,
-0.009776561,
-0.013216089,
-0.02608421,
-0.0029694377,
-0.03316402,
0.010894072,
0.014012401,
0.0015014481,
-0.015645172,
0.0039246767,
-0.000077059005,
0.0012480003,
-0.008036721,
-0.012352861,
0.017010277,
-0.009234534,
0.014440669,
-0.03498416,
0.0007147562,
0.009134158,
-0.0070195836,
-0.018549368,
0.015096455,
0.023715353,
-0.028131869,
-0.0015859307,
-0.009589192,
-0.012734287,
0.03851737,
-0.0063671437,
-0.0021547244,
-0.014855553,
0.022296714,
0.015444422,
0.012553612,
0.042853586,
0.051151283,
0.0032287408,
0.010017461,
0.010479188,
0.0008030029,
-0.0051760226,
-0.01005092,
-0.0138518,
0.010820464,
0.0063537606,
-0.007702136,
-0.034395292,
0.014976004,
-0.006407294,
-0.013075564,
0.011134974,
0.008424839,
0.00095356593,
0.0037138883,
-0.0023538023,
0.0276233,
0.0077155195,
0.0037138883,
-0.0043362156,
0.020730859,
0.017451929,
0.0041254275,
-0.01005092,
-0.021640928,
-0.010064303,
-0.014480819,
-0.001925534,
-0.0041823066,
0.0059020715,
-0.008371306,
-0.02552211,
0.009723026,
0.0017816627,
-0.015457806,
-0.01025167,
0.042907123,
-0.0016285903,
-0.0069325916,
0.02101191,
-0.025080457,
-0.005343315,
0.010117836,
-0.0069125164,
-0.0115967,
0.03193275,
-0.015096455,
0.021935362,
-0.015752241,
-0.0089735575,
-0.0025495342,
-0.031049445,
-0.024237305,
0.0050756475,
-0.019151619,
-0.016689077,
-0.009348292,
0.015230289,
0.005631058,
-0.030246442,
0.025642559,
0.0033726122,
-0.0072604846,
-0.027221799,
-0.017759748,
0.029550506,
0.032307483,
-0.03554626,
-0.01191121,
0.004439937,
0.03629573,
0.019017786,
0.01286143,
-0.002900848,
0.016715843,
0.013088947,
-0.019753871,
0.013865183,
-0.0090471655,
0.0032772555,
0.011141665,
0.0021162473,
0.022832049,
-0.0016670675,
-0.0130554885,
-0.0011978126,
-0.0003368848,
-0.007588377,
0.010037536,
0.008371306,
0.02034274,
0.013403457,
0.00017210192,
0.007186876,
-0.008210705,
0.0041622315,
0.025642559,
-0.044673726,
0.012854738,
-0.002056022,
0.020396274,
0.025816543,
0.02418377,
-0.011235349,
-0.0015625098,
-0.003830993,
0.008899949,
0.021078827,
0.039240073,
-0.03011261,
0.008404763,
0.013657741,
0.015524723,
0.016755994,
-0.006186468,
-0.0008205686,
0.0019171694,
-0.0070062005,
-0.011482941,
-0.63512176,
-0.017371628,
0.023367384,
-0.009502201,
-0.004764484,
0.031718615,
-0.0038008804,
-0.0007185203,
0.012406395,
0.050321516,
-0.0069192084,
0.03918654,
-0.009756485,
-0.02600391,
-0.0061329347,
-0.010840539,
-0.0034763333,
-0.004463358,
0.010485879,
-0.01662216,
-0.0023287083,
0.0088129565,
0.006149664,
0.023206783,
0.0020627137,
0.02481279,
0.022965882,
-0.03423469,
-0.0010848903,
-0.009147542,
0.0047109504,
0.009937161,
0.007213643,
0.009147542,
0.06632804,
-0.0365634,
-0.002900848,
0.028854571,
0.0047310255,
0.015805773,
-0.018054182,
-0.0024508317,
0.034689724,
-0.008766115,
-0.0010999467,
0.005865267,
0.020115223,
-0.002445813,
0.013155865,
-0.008545289,
0.023742119,
-0.0022233143,
-0.0068857498,
0.0017147458,
-0.0034227998,
-0.0033491913,
0.018107716,
-0.0063571064,
-0.0055306824,
0.00878619,
-0.00736086,
-0.0038176095,
-0.017666064,
-0.005433653,
-0.024678955,
0.027034432,
-0.012225719,
0.016595393,
0.0020660595,
-0.010532721,
0.015056305,
0.030299976,
-0.0045771166,
-0.0073876265,
0.013450298,
0.025776394,
0.027395783,
0.02422392,
-0.017130729,
-0.005129181,
0.010853923,
-0.0035566336,
-0.03316402,
-0.0007231208,
0.02920254,
-0.0010405579,
-0.015939608,
-0.0006909171,
-0.0052529774,
-0.004610575,
-0.011543167,
-0.008645665,
0.006012484,
-0.020878075,
0.012600454,
0.034047324,
0.0068723666,
0.00032224675,
0.027569765,
-0.010579563,
-0.0030346818,
0.0012856411,
-0.013403457,
-0.009415209,
0.022149496,
0.0058518834,
-0.0037908428,
0.0007072281,
0.04400456,
-0.043148022,
-0.001773298,
-0.00043705106,
-0.0004884934,
-0.023621669,
-0.0029476897,
-0.01947282,
-0.013644357,
-0.00472768,
0.005022114,
-0.020744242,
0.013918716,
-0.018924102,
0.014427286,
-0.009522276,
-0.007380935,
0.014882321,
0.016220659,
0.0038075722,
-0.008003262,
-0.023929486,
0.001309062,
-0.033190787,
0.007722211,
-0.007621836,
0.007849353,
0.008431531,
0.010472496,
-0.0071065756,
-0.02481279,
0.002833931,
-0.008404763,
0.005092377,
-0.00072437554,
0.0045235828,
-0.014280068,
-0.01630096,
-0.0009636035,
-0.0010112817,
0.0063738353,
0.0030196256,
-0.021346495,
-0.005386811,
-0.012935039,
0.0058385003,
-0.015270438,
-0.020958375,
-0.02113236,
-0.027489467,
-0.0060894387,
-0.002163089,
0.012734287,
0.032280717,
-0.032013047,
0.009254608,
-0.020008156,
-0.030540876,
-0.009963928,
0.009622651,
-0.02473249,
-0.029577274,
0.00013048797,
-0.047484238,
-0.012245794,
0.023996403,
0.016929979,
-0.01021152,
-0.017947115,
0.007635219,
0.008799573,
0.013329848,
0.0022668103,
-0.038008805,
-0.017277945,
-0.011871059,
0.03209335,
-0.0057247416,
0.017746365,
-0.0277839,
0.002748612,
0.009234534,
0.009749793,
0.0034763333,
-0.0231131,
0.016086824,
0.0017147458,
0.011155048,
0.0076954444,
-0.00034023065,
-0.004741063,
0.033378154,
0.025977144,
-0.012968496,
0.019486204,
0.010981064,
0.0040350896,
-0.023568135,
0.013369998,
-0.024264071,
0.0068723666,
-0.007300635,
-0.0046206126,
-0.0071935677,
0.010987756,
-0.021560628,
-0.0035265211,
0.017719597,
-0.013637666,
-0.0039748643,
-0.026365262,
0.014949237,
0.01060633,
-0.011295574,
0.03265545,
-0.0058050416,
-0.009515584,
-0.0013776518,
0.009328217,
-0.008257546,
0.01139595,
-0.017599147,
0.0027586496,
0.009107391,
-0.011623467,
0.013577441,
-0.008277621,
0.012841355,
0.0031902636,
-0.01345699,
0.020048305,
-0.0016411372,
0.0043127947,
-0.0033893413,
0.017987264,
0.016595393,
0.027864201,
0.002596376,
0.034502357,
0.006815487,
-0.03134388,
0.0065344363,
-0.01389195,
-0.00013121987,
-0.014855553,
-0.0010405579,
-0.00463065,
-0.008799573,
0.010124528,
0.004409824,
0.014467436,
0.013744733,
0.017987264,
0.010452421,
0.018268315,
-0.0050789933,
-0.016220659,
-0.0021798182,
-0.0185226,
-0.008036721,
0.004178961,
-0.023153251,
-0.018549368,
-0.004567079,
0.012393012,
-0.018535983,
0.022684831,
0.0018686546,
0.012988572,
-0.0042291484,
-0.007099884,
-0.014949237,
-0.00045461673,
-0.017398397,
0.0032170303,
0.049170543,
-0.021640928,
-0.005212827,
0.013758116,
0.0047979425,
-0.025669325,
0.007293943,
-0.01555149,
0.0070530423,
-0.014775253,
-0.004362982,
0.008772806,
-0.028238935,
0.010746855,
-0.011937977,
0.0018017377,
0.0017850085,
0.015698707,
-0.0022383705,
-0.0055106073,
-0.03958804,
0.03929361,
-0.0003151368,
-0.0040785857,
-0.006705074,
0.0018351962,
-0.006316956,
-0.008505139,
-0.009027091,
-0.0039280225,
-0.003439529,
0.030567644,
0.0002524022,
-0.024786023,
0.00973641,
0.03407409,
0.0014797001,
0.008612206,
-0.025361508,
0.0132896975,
0.0053968485,
0.076874144,
0.0111684315,
-0.0124264695,
0.030995911,
0.008685814,
-0.006624774,
-0.0028724084,
-0.032013047,
0.034288224,
0.0015098128,
-0.011777376,
0.021547245,
0.008230779,
-0.0047912505,
0.019954622,
0.020623792,
0.00835123,
0.0019857592,
-0.03846384,
0.0032120117,
0.00078041846,
-0.0053533525,
0.021560628,
0.03455589,
0.0042726444,
-0.028506603,
0.0230328,
0.02612436,
-0.0071333423,
-0.0072537926,
-0.014427286,
0.0075214603,
-0.016314343,
0.030888844,
-0.017960498,
0.009937161,
0.017625913,
-0.0058284625,
-0.0015608369,
0.004439937,
0.016394643,
-0.0014713355,
0.0037741137,
-0.004409824,
0.0024575235,
-0.00930145,
0.012326094,
0.032227185,
0.0007574158,
-0.0281051,
0.028426303,
-0.01476187,
-0.038490605,
-0.015886074,
0.03193275,
0.0038042262,
-0.01769283,
-0.0049652345,
0.010325279,
-0.0055942535,
-0.026164511,
-0.03629573,
0.010398887,
-0.01682291,
0.0004905846,
-0.019285453,
-0.007641911,
-0.0012730942,
-0.020677324,
-0.023755502,
0.020744242,
-0.005149256,
-0.020530106,
-0.015056305,
0.0031066174,
0.009482126,
0.033859957,
-0.020985143,
-0.0028038186,
0.010920839,
-0.037901737,
-0.0061329347,
-0.026820296,
-0.012285944,
0.024197154,
0.0076285275,
0.019887704,
-0.037232567,
-0.015083071,
0.021667695,
0.013015338,
0.015042921,
-0.0061831223,
-0.013001955,
-0.004342907,
0.01943267,
0.028747505,
0.019365754,
0.0044432827,
-0.027998034,
0.01080708,
0.00060308864,
-0.021788144,
-0.01195136,
0.018188016,
-0.020128606,
-0.0051157977,
0.01084723,
0.013758116,
-0.010218211,
0.031210046,
-0.024250688,
0.009756485,
-0.0137714995,
0.014494202,
0.023354001,
-0.008291005,
0.04250562,
0.006792066,
-0.027034432,
-0.03276252,
-0.00036720652,
0.0053366236,
0.041301116,
0.0028506604,
0.004108698,
0.007160109,
-0.032949887,
-0.027837433,
-0.005433653,
-0.012419778,
0.028747505,
0.02220303,
-0.017077195,
-0.015149988,
0.007896195,
0.026110977,
0.0047879047,
-0.021855062,
-0.034288224,
-0.011248732,
-0.017304713,
-0.0009217804,
-0.027596533,
0.064775564,
-0.03166508,
-0.000384354,
-0.004409824,
-0.0036603548,
0.034047324,
-0.0276233,
-0.009361675,
-0.011288882,
-0.011697075,
-0.0052897814,
-0.03645633,
-0.0039480976,
-0.0003149277,
0.023809036,
0.022029046,
0.01959327,
0.0054436903,
-0.0016971801,
0.015083071,
0.025388274,
-0.014628036,
0.0061797765,
0.005644441,
-0.009756485,
0.00973641,
0.025763009,
0.0017348209,
-0.014989387,
0.00013582042,
0.020677324,
-0.02038289,
-0.011108207,
-0.04349599,
-0.0014587886,
-0.051981054,
-0.0037306177,
-0.010519338,
0.0034043978,
0.0036402799,
-0.051070984,
0.0027302098,
0.039882477,
0.0041020066,
0.009977311,
-0.008920024,
0.018335233,
-0.019807404,
-0.012225719,
0.012292636,
0.033378154,
-0.011369183,
-0.027650066,
-0.025107224,
0.024598656,
0.0049853097,
-0.00433287,
0.015431039,
0.038330004,
-0.009763177,
-0.006959358,
0.029229306,
-0.012928346,
0.0059790257,
0.025227675,
-0.033110484,
-0.016956745,
-0.013242856,
-0.020891458,
-0.029470207,
0.007574994,
-0.0044031325,
-0.009910394,
0.01939252,
-0.03241455,
-0.01139595,
-0.028346002,
-0.01832185,
0.004031744,
-0.010244979,
0.032682218,
0.011054673,
0.0064106397,
-0.025642559,
0.00815048,
-0.0028289123,
0.010111145,
0.038570907,
0.031905983,
-0.021828296,
-0.021681078,
-0.013717966,
0.029550506,
-0.0182817,
-0.024090087,
0.022296714,
0.012694137,
-0.03193275,
-0.011864368,
-0.025535492,
0.01939252,
0.017277945,
0.0114160245,
-0.018576134,
0.025374891,
-0.01789358,
-0.0013517216,
0.01943267,
-0.02952374,
0.029149005,
0.016461559,
-0.00886649,
-0.0057448167,
-0.035599794,
0.0022617914,
0.0045804624,
-0.024826173,
-0.008036721,
-0.017264562,
-0.0034897167,
0.015243672,
0.0068455995,
0.01642141,
0.018361999,
-0.01990109,
0.033886723,
0.0094419755,
-0.03514476,
-0.0070062005,
-0.019298837,
0.0028975022,
-0.013503832,
-0.018817034,
-0.013209398,
-0.02026244,
-0.004570425,
0.0067619537,
0.0061597014,
-0.003657009,
0.025575642,
-0.0051860604,
-0.02129296,
-0.002293577,
-0.001773298,
0.020824542,
-0.0033157328,
-0.026298344,
0.00053449883,
-0.01753223,
-0.014989387,
0.0014905741,
-0.016193891,
0.004764484,
0.019633422,
-0.009963928,
0.015297205,
0.0071065756,
0.0062801517,
0.0044064783,
0.009669493,
-0.015364122,
-0.006206543,
0.03980218,
0.0057046665,
-0.01654186,
0.015203522,
0.012848047,
0.014534352,
0.00025846655,
0.00014857645,
0.018375384,
0.0048380923,
-0.014494202,
-0.006507669,
-0.016635543,
0.035519496,
-0.020944992,
0.007815895,
0.032013047,
-0.019057935,
0.016595393,
-0.040391047,
0.031879216,
0.014454052,
-0.028667204,
-0.009013708,
-0.011837601,
0.008699198,
-0.023581518,
0.0033207515,
-0.0034294915,
0.0009050512,
-0.016274191,
0.005995755,
0.00030614485,
0.0067452244,
-0.005922146,
-0.026338495,
-0.030701477,
-0.0150295375,
0.009020399,
-0.012767746,
0.0013391746,
-0.025040306,
-0.048394307,
0.009482126,
-0.011335724,
0.047109503,
0.02204243,
-0.020249056,
-0.01587269,
0.0006792066,
-0.028319236,
0.01658201,
0.0075482274,
0.014132851,
0.00736086,
0.014775253,
0.0046574166,
0.020249056,
-0.014454052,
0.015845925,
-0.008879874,
-0.024652189,
0.017465314,
0.01195136,
0.037152268,
-0.012680754,
-0.019178385,
0.0035399045,
0.02960404,
0.010880689,
0.008217396,
0.024946623,
0.0028071643,
0.008505139,
0.004041781,
-0.0000035484259,
-0.010526029,
-0.0026867138,
-0.00492843,
-0.010439037,
-0.010532721,
0.009810018,
-0.009910394,
-0.013905333,
-0.014547735,
0.012386319,
0.013671124,
-0.0042023817,
-0.027489467,
0.0053098565,
-0.0000010080013,
-0.014065934,
0.017545613,
-0.0028473143,
-0.01116174,
0.019780638,
-0.0004621449,
-0.018817034,
-0.011616775,
0.013122406,
-0.03498416,
-0.020958375,
-0.010532721,
-0.0098367855,
-0.009843477,
-0.0060693636,
0.008424839,
-0.03396702,
-0.0022249871,
-0.037098736,
-0.012018276,
-0.01911147,
0.009789944,
-0.0111818155,
-0.009789944,
0.010278437,
0.006240002,
-0.011984819,
0.0016386277,
-0.014494202,
0.011074748,
-0.03554626,
0.019767255,
-0.01773298,
0.0103052035,
-0.0065879696,
-0.0045135454,
0.009923778,
-0.017184261,
0.014949237,
0.2106009,
-0.00480798,
0.008638972,
-0.012352861,
-0.028854571,
-0.014306835,
0.031236812,
-0.006514361,
0.007421085,
0.010967681,
-0.003964827,
0.015096455,
0.0056645162,
0.0015959683,
0.0017933731,
-0.0067218035,
-0.028372768,
-0.011014523,
-0.018576134,
0.0015784026,
0.0041722693,
0.0042057275,
-0.030755011,
0.0046708,
0.01959327,
0.01555149,
-0.009334909,
0.0038042262,
-0.0005938876,
-0.0051526017,
-0.01891072,
-0.008766115,
0.008551981,
0.010820464,
-0.011496325,
-0.009288067,
-0.002623143,
-0.0126740625,
-0.005497224,
0.008143787,
-0.009147542,
0.037286103,
0.0034361833,
-0.019566504,
-0.009053858,
0.03067471,
0.008070179,
-0.0277036,
-0.0025545529,
0.0013993998,
-0.024116853,
0.017599147,
0.011683692,
-0.007293943,
-0.012868121,
-0.0010355392,
-0.01199151,
0.013717966,
0.010017461,
0.017880198,
-0.011804143,
-0.008464989,
-0.014895704,
0.009977311,
-0.0042759907,
0.029496973,
0.0033491913,
0.005062264,
0.028560136,
-0.018790267,
0.006464173,
-0.03182568,
-0.04448636,
0.012326094,
-0.022631299,
-0.01777313,
0.021052059,
0.011857676,
0.007093192,
0.005045535,
-0.009669493,
-0.010613021,
-0.03169185,
0.004128773,
-0.006316956,
-0.035680097,
-0.0012421451,
0.009027091,
-0.007789128,
0.0011434427,
0.0037707677,
0.011248732,
-0.01389195,
-0.010425654,
-0.0042960653,
-0.0040551648,
0.026137745,
0.016073441,
0.009963928,
-0.029068705,
-0.007849353,
0.06595331,
0.007247101,
0.028078334,
0.00433287,
-0.0076753693,
-0.011656925,
0.0276233,
-0.016073441,
-0.025977144,
0.0040384354,
-0.02133311,
0.00815048,
-0.011503017,
-0.013028722,
0.031156512,
0.0073207095,
-0.01642141,
-0.0016871425,
-0.026927363,
0.0034997542,
-0.016220659,
0.009984002,
0.03289635,
-0.0059388755,
-0.01741178,
-0.00791627,
0.014039167,
-0.025120607,
-0.016595393,
-0.0038209555,
-0.032200415,
0.004001631,
-0.010385504,
-0.0020510033,
0.018455682,
0.017237796,
0.003570017,
0.020155372,
0.021038676,
-0.004306103,
0.010472496,
0.008846415,
0.015042921,
0.006189814,
-0.015966374,
0.016755994,
-0.0024056628,
-0.015618406,
-0.007936345,
-0.025334742,
0.00298784,
0.025307974,
-0.01254692,
0.02418377,
-0.00874604,
-0.0027435932,
-0.026044061,
0.020034922,
-0.002271829,
-0.009415209,
0.030246442,
0.019004403,
-0.005995755,
-0.019446053,
-0.0040551648,
-0.16970128,
0.017023662,
0.016528476,
-0.012051735,
0.029122239,
-0.005239594,
0.014173001,
0.030540876,
0.0023354,
-0.00894679,
0.04274652,
-0.007769053,
-0.025267825,
-0.018268315,
0.0011501344,
-0.0056779,
-0.008418147,
0.04167585,
-0.0035532878,
0.01116174,
0.016970128,
-0.00031095452,
-0.020476574,
0.0011777376,
0.01630096,
0.00026264886,
-0.009689569,
0.00062400015,
-0.012660679,
-0.035519496,
-0.045610566,
0.009174308,
0.023180017,
0.016916594,
-0.010840539,
0.006959358,
-0.015096455,
0.00019060863,
-0.02659278,
0.0121922605,
0.005005385,
0.028988404,
0.016327726,
0.010773622,
-0.021681078,
-0.002251754,
0.0066983826,
-0.011389257,
0.01741178,
-0.007180184,
-0.0055708326,
-0.023380768,
-0.01500277,
0.016715843,
0.01064648,
-0.006792066,
0.0036436256,
-0.017224412,
-0.004650725,
0.024290837,
-0.016260808,
-0.010378812,
0.040417813,
0.0031450947,
-0.0056946287,
-0.046761535,
-0.012312711,
0.010693322,
-0.024130236,
0.0039915936,
-0.02030259,
0.00973641,
-0.008043412,
-0.016889827,
0.01060633,
0.01848245,
-0.014614653,
0.015390889,
-0.020195523,
-0.0031015987,
-0.009816711,
0.0062901895,
-0.028854571,
0.010914148,
-0.01971372,
-0.00019615018,
0.018094331,
0.010873998,
0.005560795,
-0.018830419,
0.026137745,
-0.013349923,
0.006815487,
-0.0030564298,
0.02600391,
-0.002337073,
-0.005801696,
0.01017137,
-0.002768687,
0.0022801936,
-0.002572955,
-0.0018000648,
-0.020931609,
0.02699428,
0.007314018,
0.00037682583,
-0.0048648594,
0.0037172341,
0.033779655,
-0.009160925,
-0.00026954967,
0.023099717,
-0.0058819964,
0.019218536,
-0.010331971,
0.021788144,
0.0036068214,
0.0017799898,
-0.011663617,
-0.022524232,
0.055781934,
-0.018428916,
0.0051592938,
0.0016143704,
0.0034110893,
-0.025000157,
-0.11531121,
-0.017947115,
0.029256072,
-0.0010096089,
-0.001124204,
0.026365262,
-0.0044232076,
-0.008632281,
-0.011603392,
0.022778515,
-0.027864201,
-0.048233707,
-0.007501385,
0.0020175448,
0.06027875,
0.0014571156,
-0.008920024,
-0.04809987,
-0.032307483,
0.024852939,
0.009776561,
0.0075415354,
0.001546617,
-0.01729133,
-0.036215432,
-0.023501217,
-0.012827971,
0.005005385,
-0.0023705314,
0.003071486,
-0.0010238288,
-0.0075281523,
0.024237305,
-0.01310233,
-0.028292468,
0.002577974,
-0.030219676,
-0.020597024,
0.0117974505,
-0.014092701,
0.014494202,
0.021025293,
0.022497464,
0.010532721,
-0.008237472,
-0.019124852,
0.008993632,
0.0273021,
0.01460127,
-0.012393012,
-0.0017113999,
-0.009247917,
-0.008886565,
-0.009167616,
0.020717476,
-0.006216581,
0.038249705,
-0.008920024,
-0.019834172,
0.030621177,
0.0077824364,
0.018991018,
-0.021761378,
0.012593762,
-0.0010238288,
-0.013865183,
-0.044673726,
-0.030540876,
0.021935362,
-0.032227185,
-0.036376033,
0.0013818342,
-0.0029192502,
0.01460127,
-0.014989387,
-0.010907456,
-0.0035332127,
0.0014219843,
0.022965882,
-0.015390889,
-0.020195523,
-0.020168755,
-0.0012463274,
-0.023487834,
0.017117346,
-0.006728495,
0.008551981,
-0.004694221,
-0.0025930302,
-0.013155865,
0.018830419,
0.023206783,
-0.0010413944,
-0.013878567,
0.01191121,
0.027516233,
-0.002469234,
-0.026151128,
-0.004503508,
0.020409657,
-0.022898966,
0.002275175,
-0.040551648,
0.0056578247,
0.021239426,
0.004563733,
-0.028560136,
-0.018589517,
0.021654312,
0.002464215,
0.006972742,
-0.0019991426,
-0.013048797,
0.017157495,
-0.0034897167,
-0.003506446,
-0.034743257,
-0.030326743,
0.0368043,
0.028292468,
0.027154882,
0.0018987673,
0.009334909,
-0.015216905,
0.018067565,
0.01286143,
0.017398397,
0.007922962,
0.00097280456,
0.014173001,
0.01381165,
0.0014002363,
0.028961638,
-0.028024802,
-0.012366245,
-0.0077355946,
-0.024116853,
-0.032280717,
0.013443607,
-0.002464215,
0.040176913,
0.033940256,
-0.01872335,
-0.019218536,
-0.012051735,
-0.037687603,
-0.00080927636,
0.017237796,
-0.028024802,
0.021547245,
0.0035399045,
-0.019044552,
0.028560136,
-0.0006541128,
-0.03562656,
-0.014306835,
-0.008210705,
0.006142972,
0.004560387,
0.027837433,
-0.008304388,
0.0025863384,
0.021774761,
-0.022269947,
0.025776394,
-0.0013910353,
0.05733441,
-0.023300467,
-0.04116728,
-0.0016386277,
0.013677816,
-0.019633422,
-0.010760238,
-0.017759748,
-0.004342907,
0.008986941,
-0.0013483757,
-0.020008156,
-0.00046716366,
0.0034729876,
-0.021306343,
0.008853107,
0.01919177,
0.015618406,
-0.028667204,
0.015149988,
0.037339635,
-0.005410232,
-0.018843802,
0.032200415,
-0.00077958195,
0.01060633,
-0.024585271,
0.016769378,
-0.012553612,
0.012393012,
0.019057935,
0.023835802,
0.0008368796,
-0.003332462,
0.024652189,
-0.0052697067,
-0.0005048044,
0.007160109,
0.018388767,
-0.013122406,
-0.010552797,
-0.0034462207,
-0.0045235828,
-0.026780147,
-0.007969804,
-0.0007172656,
0.005022114,
0.027810667,
-0.0018201399,
0.012232411,
-0.008083562,
0.01848245,
0.014668186,
0.013129097,
-0.013717966,
0.03466296,
0.007635219,
-0.0023253625,
0.01341684,
-0.015899457,
0.030808544,
-0.0013751425,
0.006209889,
-0.013430224,
0.05093715,
-0.0074077016,
-0.00331406,
-0.005343315,
-0.016876444,
0.005801696,
0.024237305,
-0.02169446,
0.034341756,
0.020998526,
0.030728243,
0.05240932,
0.0048113256,
-0.028292468,
-0.024558505,
0.0025043653,
-0.0006804613,
0.0012354534,
0.011068056,
-0.0014119467,
-0.012393012,
0.008518523,
0.0044466285,
0.014253302,
-0.022510847,
0.014467436,
0.011141665,
-0.009756485,
0.023755502,
0.001350885,
0.021359878,
0.02683368,
0.0103052035,
0.03522506,
0.023568135,
-0.024438055,
-0.010244979,
0.019606654,
-0.004520237,
0.0064206775,
-0.025067074,
-0.013517216,
0.017023662,
0.0015549817,
-0.032200415,
0.016996894,
-0.0057950043,
0.0033291162,
-0.012928346,
0.012560303,
0.006691691,
0.018348616,
0.020075072,
-0.024558505,
-0.026927363,
-0.03589423,
-0.0032003012,
-0.009850169,
-0.04250562,
-0.012145419
] |
The Constant-Murley shoulder assessment score has proven to be a valuable diagnostic instrument. Thus, in the literature it has been mentioned that the clinical accuracy of this score varies especially when comparing patients in larger, inhomogeneous patient groups. The "relative Constant score" (CS(rel)) tries to minimize these problems by using reference parameters out of healthy age and gender related control groups. The authors of this study tried to show that it is even more accurate to use the functional performance of the uninjured collateral shoulder of the same individual as reference, introducing the "individual relative Constant score" (CS(indiv)). The CS(indiv) and the | [
-0.0064435387,
0.0012274618,
0.02793218,
-0.019327223,
-0.0061449436,
0.0070305485,
-0.0032048037,
0.008883193,
-0.017087761,
-0.02509553,
0.013674282,
0.0131856715,
-0.0041396087,
0.0051066484,
-0.0030962238,
0.0022191016,
0.02601846,
0.001234248,
0.015974818,
-0.027986469,
-0.020806624,
0.014576851,
-0.053557035,
-0.026982106,
-0.023480404,
0.017861394,
0.034338392,
-0.040283144,
0.030348083,
-0.031162431,
0.026615648,
0.0022496397,
-0.030782402,
-0.026479924,
-0.02601846,
-0.010627258,
-0.0014861875,
-0.019883694,
0.008598171,
-0.02111879,
0.0216074,
-0.0017203127,
-0.01871646,
0.013083878,
-0.00033676735,
0.0040208492,
-0.006066902,
-0.031813912,
-0.015961245,
0.022014575,
0.0063858554,
0.023263244,
-0.042210437,
0.004095498,
0.026127039,
-0.0107086925,
0.009595749,
0.03398551,
0.005897246,
-0.022163872,
-0.006063509,
-0.011143012,
-0.007437723,
0.016327703,
-0.011624835,
-0.01839072,
-0.006769278,
-0.008394584,
0.012961726,
0.036591426,
0.0272807,
0.04910526,
-0.013144954,
0.014807584,
0.022991793,
-0.007654883,
-0.0043364097,
-0.026615648,
0.021200225,
-0.0032675765,
0.018580735,
-0.029533733,
-0.006426573,
-0.010267586,
0.0013436762,
0.000299443,
0.017264204,
0.013898227,
-0.006094047,
-0.0014675253,
0.017535655,
0.004590894,
0.0021257908,
-0.030293792,
-0.030320937,
-0.0012333998,
0.024634065,
0.008523522,
0.007125556,
-0.00861853,
-0.0050319997,
-0.0013920283,
-0.010878349,
-0.022286024,
-0.02880082,
-0.029262284,
0.004587501,
-0.020046564,
-0.004204078,
-0.029750893,
-0.012887077,
0.021132363,
-0.007132342,
-0.017657807,
0.03279113,
-0.018363576,
-0.0063112066,
0.005724197,
0.003160693,
-0.00086142885,
0.010762983,
0.007566662,
0.043784846,
-0.018078554,
0.007057694,
0.0074241506,
-0.019788686,
0.01587981,
-0.028963689,
-0.008299576,
0.0015006082,
0.017861394,
0.0118759265,
0.026982106,
0.0024515307,
0.005707231,
-0.0054425676,
0.02101021,
-0.01412896,
-0.020765906,
0.0056733,
0.0079466915,
-0.03631998,
-0.027986469,
-0.007464868,
-0.0033608873,
0.03159675,
0.028909398,
-0.016137687,
-0.0044042724,
-0.024810508,
-0.01402038,
0.025529848,
0.005754735,
0.01739993,
-0.018675743,
-0.0031335482,
0.035342757,
0.004254975,
-0.034284104,
-0.016124114,
0.023874005,
-0.00534756,
-0.0146854315,
-0.008014554,
0.0075530894,
0.00085209776,
-0.005008248,
-0.00010985232,
0.014603997,
0.01102086,
0.03922449,
-0.01625984,
0.010145434,
0.0027586082,
0.0048657367,
0.0063654967,
0.0057445555,
-0.017603517,
-0.03846443,
-0.012398467,
0.009724688,
0.027796455,
0.025923451,
0.006596229,
0.021078072,
0.02542127,
0.019517237,
0.012724207,
-0.007987409,
0.0067048087,
0.006124585,
0.012914222,
-0.03322545,
-0.6189054,
-0.01020651,
-0.0018373755,
-0.0019035414,
0.021295233,
0.022462467,
0.018906476,
-0.0048284126,
-0.0145904245,
0.046526488,
-0.011787705,
0.013429976,
-0.020684471,
-0.030049488,
-0.016164834,
-0.018960765,
-0.011916644,
-0.017006326,
0.02155311,
0.0018238031,
-0.025543422,
0.030592388,
-0.007573448,
0.018458582,
-0.0013377384,
-0.005116828,
0.009093567,
-0.026927816,
0.009005345,
-0.00035670193,
-0.021227371,
0.019815832,
0.0062195924,
0.014617569,
0.036808588,
-0.030483807,
-0.01909649,
0.004896275,
0.015784804,
0.0340398,
-0.029479444,
-0.01587981,
0.03251968,
-0.0064638974,
-0.014766866,
0.023806144,
-0.00679303,
-0.0069762585,
0.007736318,
-0.021539537,
0.0004201109,
-0.0027111045,
0.02209601,
0.014033952,
-0.008143493,
-0.06411643,
0.007376647,
-0.0071730595,
-0.0064638974,
-0.004563749,
-0.015906956,
0.00027950841,
0.0050625377,
-0.020100854,
0.00062263786,
0.016273413,
-0.000834708,
-0.0091139255,
-0.0012121928,
0.011543401,
0.018363576,
0.022733917,
-0.005866708,
0.014047525,
-0.010145434,
0.03574993,
0.014549707,
-0.0058938526,
0.0048521645,
0.01380322,
0.002604221,
0.0009984261,
-0.015160468,
0.020290868,
-0.013606419,
-0.00039423836,
-0.021702407,
0.00012130411,
0.0043533756,
-0.01587981,
0.020426594,
0.014346119,
0.008543881,
-0.027077112,
-0.0066742706,
0.0391702,
-0.041314654,
-0.00082240795,
0.017535655,
-0.048155185,
-0.032954,
-0.012493474,
0.020915203,
0.017603517,
0.0068032094,
0.009663612,
-0.016544862,
0.013104237,
0.054045647,
-0.043893427,
-0.00017061041,
-0.0035797437,
-0.009812908,
-0.0009212326,
0.013633564,
-0.03127101,
0.027063541,
0.015024744,
-0.000012611545,
-0.014115388,
0.0017016507,
-0.009378589,
0.024674783,
-0.0071594873,
-0.011319455,
0.030836692,
-0.00008731987,
0.0058124177,
0.0033252595,
-0.017101334,
0.015133324,
-0.027212838,
0.0075530894,
-0.017576372,
0.034881294,
0.005300056,
0.012330605,
-0.020250151,
-0.003535633,
-0.01293458,
-0.04299764,
-0.021865278,
0.008319935,
0.005490071,
0.006565691,
-0.033361174,
-0.044110585,
0.0032743625,
0.0047164396,
-0.00016446038,
-0.020263724,
-0.026357772,
-0.0036781442,
-0.010287946,
-0.021702407,
0.0021614186,
0.0044924933,
-0.0120863,
-0.010233656,
-0.028719384,
-0.029615168,
0.027986469,
-0.024864797,
-0.010634044,
-0.0061686956,
-0.009005345,
-0.0067760646,
0.005059145,
-0.036700007,
-0.047449417,
-0.018431438,
0.011998079,
0.0061381576,
0.0076684556,
0.011998079,
0.00056028925,
-0.028909398,
-0.016667014,
0.0027111045,
-0.01855359,
0.01091228,
0.0029825543,
-0.0030996168,
-0.013592847,
0.029126558,
0.011991293,
0.0080416985,
-0.018254995,
-0.018702889,
0.01953081,
0.011244806,
0.012982084,
-0.028122194,
0.011258379,
-0.0068574995,
0.009527886,
-0.012764924,
0.011258379,
0.013267106,
0.013355328,
0.022815352,
0.011516255,
0.049621016,
-0.0106136855,
0.017712096,
-0.037622936,
0.021227371,
0.008177424,
0.018092126,
0.0005034545,
-0.0038885176,
-0.002700925,
-0.0019798866,
-0.028339354,
-0.019775115,
0.020209434,
0.021485249,
0.0055477545,
0.014861874,
-0.00080247334,
0.0092089325,
-0.00064554147,
0.031488173,
0.0076752417,
0.005904032,
-0.002650028,
0.014631142,
-0.0044415966,
0.011421248,
0.011373744,
0.0013131382,
-0.0024091166,
0.030755257,
0.003589923,
0.0063146,
0.02101021,
0.00850995,
-0.008794972,
0.015418346,
0.011115868,
0.01598839,
0.0072748535,
-0.0034558948,
-0.021254515,
0.026439207,
-0.017942829,
0.0151740415,
0.029696602,
0.025326261,
-0.019937985,
-0.008068844,
0.008638889,
-0.01150947,
0.005842956,
0.0005912515,
0.02341254,
0.012188094,
-0.009181788,
0.03661857,
0.014861874,
0.0022004396,
0.02149882,
0.010199725,
0.012676704,
0.016504144,
0.0010153918,
-0.014631142,
-0.009385375,
0.00072782463,
-0.036455702,
0.004896275,
-0.009616108,
0.0003187414,
0.0060838675,
0.010627258,
-0.003790117,
0.054697126,
0.03143388,
0.02379257,
-0.008224928,
-0.013884655,
-0.045929298,
0.023480404,
0.018309286,
-0.018377148,
0.0066098017,
-0.011848781,
0.0032489141,
-0.010824059,
0.014047525,
-0.016354848,
-0.0042990856,
0.0030809548,
-0.00701019,
0.014481844,
0.0030741685,
0.013334969,
-0.008062057,
0.0018730033,
-0.019245787,
0.015065461,
-0.013491053,
0.007186632,
-0.030728113,
0.011801278,
0.034609843,
-0.033632625,
-0.014196822,
-0.010600112,
-0.0029825543,
0.016341275,
-0.017277777,
-0.00679303,
0.009588962,
0.040717464,
0.0022632123,
-0.0007948388,
0.006603015,
0.008564239,
-0.017752813,
-0.013674282,
-0.012690276,
-0.019707251,
-0.015391201,
0.056732997,
0.02586916,
0.010226869,
0.018906476,
0.021295233,
-0.007627738,
-0.017006326,
-0.03175962,
0.037460066,
0.015255476,
-0.034229815,
0.009012132,
0.009595749,
-0.012106659,
0.008428515,
0.018540017,
0.03268255,
-0.014115388,
-0.015594788,
0.013362114,
-0.009283582,
0.009446451,
0.040446013,
0.043296237,
0.0001312714,
-0.017481364,
0.01985655,
0.013443549,
0.008713537,
-0.032926854,
-0.024213318,
0.02738928,
-0.024376187,
0.012656345,
-0.018702889,
-0.0008283459,
0.0059108185,
0.010274373,
0.023466831,
-0.0015718638,
0.003377853,
-0.0057275896,
0.008713537,
0.0159341,
0.0027111045,
-0.010667975,
-0.0008308907,
0.0072816396,
0.001058654,
-0.0037052892,
-0.0024294753,
-0.01777996,
0.016477,
-0.0057208035,
0.013606419,
-0.02139024,
-0.015309766,
0.00979255,
-0.023358252,
-0.0044857073,
-0.025950596,
-0.0351256,
0.043784846,
0.0043805204,
-0.042726193,
-0.02433547,
-0.04948529,
-0.0007083142,
-0.01658558,
-0.008611743,
0.004567142,
-0.0031742656,
-0.0046689357,
0.012907436,
0.013830365,
0.015418346,
0.02225888,
0.00007173272,
-0.014522562,
0.011136226,
-0.015241903,
-0.005042179,
0.0059786807,
-0.014671859,
-0.0019154173,
0.012276315,
-0.00063833105,
0.0017847822,
-0.020901632,
0.0111973025,
0.0031623896,
0.0055545405,
-0.013158527,
-0.0073087844,
0.015350483,
0.015160468,
0.02455263,
0.01598839,
0.01909649,
-0.022964649,
0.039740242,
-0.035017017,
-0.013022802,
-0.011319455,
0.028176485,
0.011014074,
-0.009263223,
0.017820677,
0.008754254,
-0.01761709,
0.016164834,
-0.007919546,
0.0048046606,
-0.019666534,
0.00701019,
0.0065758703,
0.0070373346,
-0.005459533,
0.039468795,
-0.0041599674,
-0.015689796,
0.0036068887,
0.037568647,
0.008089202,
-0.0032489141,
0.00818421,
-0.017752813,
-0.029398007,
-0.031053852,
-0.00019860367,
-0.017807104,
0.03338832,
-0.018445011,
-0.012323819,
-0.0063654967,
-0.007912761,
0.006399428,
0.018350003,
-0.011991293,
0.0008550667,
-0.0074241506,
0.014780439,
-0.0062297718,
-0.015974818,
0.032492537,
-0.022774635,
-0.01290065,
0.0074987994,
-0.00024282029,
0.021376668,
-0.031053852,
0.0056291893,
0.0014463182,
0.0067523126,
-0.003759579,
-0.014563279,
-0.0076413103,
0.011903072,
0.0375415,
0.004027636,
0.029696602,
0.0016431193,
0.0026517247,
0.03137959,
0.0025550209,
0.0082385,
0.0043499824,
0.0028654914,
-0.005089683,
0.027633585,
0.029153703,
0.0076684556,
-0.0179564,
-0.013287465,
0.012968512,
0.028230775,
0.0032981145,
-0.014061097,
-0.016354848,
-0.043051932,
0.011061577,
0.0031589966,
-0.008767827,
0.0041226433,
-0.054262806,
-0.027796455,
0.016300557,
-0.001406449,
0.019557955,
-0.01920507,
0.041938987,
-0.023195382,
-0.011611263,
-0.019992275,
0.0065622977,
-0.013619991,
0.003895304,
-0.012622413,
0.0025770762,
0.0034745568,
-0.011048005,
0.03235681,
-0.002365006,
0.013606419,
-0.03398551,
-0.00561901,
-0.017209914,
-0.0055477545,
-0.008896765,
-0.0004818233,
-0.004475528,
-0.0072884257,
0.0026415454,
-0.020277297,
0.011516255,
0.012059155,
-0.016029108,
0.007464868,
-0.022842497,
0.011597691,
0.034066945,
0.005171118,
0.010382953,
-0.015920527,
0.030212358,
0.0111973025,
-0.0060261847,
-0.031569608,
0.0062806685,
0.03960452,
0.0047469777,
0.02542127,
0.034284104,
-0.015608361,
-0.0009093567,
0.012676704,
-0.0021546325,
-0.03317116,
-0.046173602,
0.014196822,
0.013056733,
-0.0029112985,
-0.024308326,
-0.003759579,
-0.013606419,
0.019191498,
-0.012798856,
-0.00042223162,
0.014875446,
-0.0045773215,
0.019069346,
0.028909398,
-0.006256917,
0.011278737,
-0.0071459147,
0.009100353,
-0.027959324,
-0.008849262,
-0.017942829,
-0.003841014,
0.02318181,
0.013952517,
-0.019747969,
-0.022489613,
-0.0011061578,
0.016979182,
0.003589923,
-0.009270009,
-0.030130923,
0.037080035,
-0.01925936,
-0.0103286635,
0.022896787,
-0.013572488,
-0.0040751393,
-0.0026415454,
-0.00057937554,
-0.03338832,
-0.012127018,
-0.0066301604,
0.029533733,
0.01866217,
-0.054208517,
0.014861874,
-0.010491533,
0.0074920133,
-0.022123154,
-0.020603037,
-0.004146395,
-0.027294273,
-0.02001942,
0.014603997,
0.0029859473,
0.040174562,
-0.0043364097,
-0.018485729,
0.009039277,
0.017874965,
-0.031352445,
0.045929298,
-0.00024218408,
-0.0037392203,
-0.035532773,
0.006535153,
0.001878093,
-0.017413503,
0.014549707,
0.0011078543,
-0.020765906,
-0.020888058,
0.003393122,
0.011584118,
-0.0011918341,
-0.013226389,
0.004455169,
0.0012910829,
-0.011909858,
-0.019082917,
-0.014305402,
-0.004953958,
-0.02242175,
-0.012059155,
0.016965609,
-0.020901632,
0.018825041,
-0.039360214,
0.007152701,
0.009392162,
-0.023276817,
0.0032234658,
0.0033676736,
0.03170533,
-0.036700007,
-0.021810988,
-0.029696602,
-0.022937505,
-0.02793218,
0.010980142,
-0.0016303951,
-0.020100854,
-0.0060295775,
-0.035342757,
-0.0058192043,
0.017006326,
-0.032763984,
-0.008801758,
-0.003009699,
-0.002029087,
-0.0032777558,
0.0052525527,
0.004838592,
0.030375227,
0.027022824,
-0.03650999,
-0.03398551,
-0.009636466,
-0.055402894,
-0.009806123,
-0.0054629263,
0.023602556,
-0.0068846443,
0.030728113,
0.0004491645,
0.029398007,
0.005072717,
0.005317022,
0.0017016507,
-0.021037355,
0.006429966,
0.024959804,
0.009806123,
0.007654883,
-0.035695642,
0.0044110585,
0.024349043,
-0.0019188104,
-0.012045583,
0.03203107,
0.022123154,
-0.0046994737,
-0.0018339824,
0.030212358,
0.009188574,
-0.0066403397,
-0.0030741685,
-0.014522562,
0.005595258,
0.005093076,
0.010002923,
0.0076888143,
0.004590894,
0.03279113,
-0.008258859,
-0.01860788,
-0.018838612,
-0.021064501,
-0.009046063,
-0.007661669,
0.021729553,
-0.0013530074,
0.003976739,
0.017684951,
-0.0031623896,
-0.0043907,
-0.0031827483,
0.0111973025,
0.0039054833,
0.00061839644,
0.011740202,
-0.0058259903,
-0.01038974,
-0.017291348,
-0.0038070828,
-0.004536604,
-0.004003884,
-0.024742644,
-0.012724207,
-0.014495417,
0.015309766,
0.0058259903,
-0.021756697,
0.008686392,
0.009066422,
-0.022109583,
-0.0016770505,
-0.00594475,
0.00022818745,
-0.02880082,
-0.0016609331,
-0.0042719403,
-0.022978222,
-0.019462947,
-0.0049675303,
-0.02039945,
-0.007349502,
0.024064021,
0.19088347,
0.009595749,
-0.0025414482,
-0.002770484,
-0.00796705,
-0.015350483,
0.014115388,
0.0058633145,
-0.024186173,
0.030619532,
0.02301894,
-0.011041218,
-0.0016711125,
0.010572968,
0.014644714,
0.0050557517,
0.0029418366,
-0.007783822,
0.0032065003,
-0.009371803,
0.006104226,
0.024484769,
-0.0015099392,
-0.021050928,
0.020643754,
0.0034643775,
0.016504144,
-0.020575892,
0.0046010735,
0.01763066,
-0.028176485,
0.0054493537,
0.0076345243,
-0.0009297154,
-0.019123634,
0.006460504,
-0.011699485,
0.004061567,
-0.0071662734,
0.008421728,
0.0071119834,
-0.017345639,
0.0041226433,
-0.0018696102,
0.0010849508,
0.012242384,
-0.0041226433,
-0.00034652257,
0.00089663244,
0.015336911,
-0.01739993,
0.010491533,
0.012676704,
0.02079305,
-0.012683489,
-0.012893863,
0.023806144,
0.00840137,
0.027728593,
-0.015079034,
-0.0106136855,
-0.016626297,
-0.018743606,
0.01598839,
-0.029262284,
0.013429976,
0.0005267822,
-0.0041226433,
-0.015092607,
-0.018892903,
0.010952998,
-0.012418826,
-0.026561359,
0.023602556,
-0.015038316,
-0.0032014104,
0.023561839,
0.023765426,
0.009731473,
0.01815999,
-0.00055053405,
0.0031776587,
-0.027755737,
0.013178886,
-0.049186695,
-0.02209601,
0.0069083963,
0.004655363,
0.0013224692,
-0.009772191,
-0.0050625377,
-0.011950576,
-0.0021699015,
-0.032546826,
0.008652461,
0.019978702,
0.002661904,
0.008788186,
-0.0025567173,
0.010036855,
-0.03911591,
0.050435364,
0.021064501,
0.007838111,
-0.00037536412,
-0.02449834,
0.001460739,
-0.0054256017,
-0.014780439,
0.0006557208,
-0.026859952,
-0.032329667,
0.010226869,
-0.00946681,
0.02482408,
0.031053852,
-0.0043907,
-0.02428118,
0.019937985,
0.00054459606,
0.014088242,
-0.0083877975,
-0.007648097,
0.014251112,
0.011360172,
-0.012120231,
-0.016124114,
-0.0004046298,
0.0038002965,
-0.018743606,
0.007905974,
-0.051358294,
0.0232361,
-0.0022309776,
0.009134284,
-0.0020206042,
0.00032849662,
-0.03447412,
-0.030592388,
-0.0056902654,
-0.0016617815,
-0.028149338,
-0.01028116,
-0.012982084,
0.024064021,
0.017834248,
0.0063553173,
0.03203107,
-0.01293458,
-0.029913763,
-0.0058599217,
0.00054162706,
0.0013945731,
-0.028556515,
0.017522082,
-0.0063044205,
-0.034392685,
-0.026819235,
0.020494455,
0.002102039,
-0.032058217,
0.018445011,
0.025068386,
0.020168716,
-0.015214759,
0.004563749,
-0.17133908,
0.017033473,
0.014522562,
-0.023711136,
0.0067217746,
0.006867679,
0.012276315,
0.026710656,
-0.021023784,
-0.024213318,
0.028203629,
0.023426114,
-0.016178405,
-0.022598192,
-0.0034949156,
-0.0035695643,
-0.006307814,
0.01866217,
0.014794012,
0.015486209,
0.044816352,
-0.038274415,
0.01123802,
0.022516757,
0.008190996,
-0.02717212,
-0.019992275,
0.030158067,
0.009867199,
-0.019435802,
-0.007234136,
0.011631622,
0.01980226,
-0.0045535695,
-0.003841014,
-0.0008660944,
-0.0040988913,
0.0056597274,
0.014373264,
0.01915078,
0.0031488172,
0.038274415,
-0.009405734,
0.029099414,
-0.0061653024,
0.03355119,
0.034175523,
-0.012317033,
0.027036395,
-0.016843457,
-0.010539036,
0.00068032095,
0.015662652,
-0.0078109666,
0.027905034,
0.0121609485,
-0.006867679,
-0.00012077393,
-0.0046926877,
-0.018621452,
-0.008299576,
-0.01224917,
-0.00561901,
-0.015594788,
-0.013348541,
-0.0010119986,
-0.0066098017,
-0.013022802,
-0.012174522,
0.02177027,
-0.0019137207,
-0.01284636,
0.007315571,
-0.033524044,
0.035098452,
0.01320603,
0.009765405,
0.024199745,
0.0021274874,
-0.014468272,
-0.0041022846,
-0.0004116281,
-0.015906956,
-0.015065461,
-0.0038478002,
-0.0016202157,
0.009046063,
0.00039890388,
0.0063892487,
0.0025278758,
0.017535655,
-0.031949636,
-0.012391681,
0.003362584,
-0.009242864,
0.013952517,
-0.025448414,
-0.03317116,
-0.0025346621,
-0.019218642,
-0.020372303,
-0.009948634,
-0.0074173645,
0.0006921969,
-0.0054425676,
-0.0013301038,
-0.016952038,
-0.01224917,
-0.0062128063,
-0.0022767847,
0.0012393377,
-0.009324299,
0.017915683,
0.036700007,
-0.020969493,
0.028285064,
-0.0039360216,
-0.002098646,
0.022503184,
0.0020426593,
0.075083,
0.00081180444,
-0.016436283,
-0.01685703,
0.023548266,
0.0012630896,
-0.12074085,
-0.0010959784,
0.013436763,
0.02493266,
0.013728571,
0.027742164,
-0.019815832,
0.0010620472,
-0.0043499824,
0.021702407,
-0.0118759265,
-0.03143388,
0.006989831,
-0.02379257,
0.002963892,
-0.008265645,
0.009222506,
-0.043051932,
-0.0040547806,
0.025747009,
0.016381992,
-0.026140612,
0.010138649,
-0.029723749,
-0.00022945987,
0.0062738825,
-0.047177967,
0.0059718946,
0.020983066,
0.0179564,
0.0011697788,
-0.00024239614,
0.0070034037,
-0.0005797997,
-0.020046564,
-0.039821677,
-0.033144016,
-0.029207993,
0.024756217,
0.009996138,
0.002828167,
0.018187134,
0.010287946,
-0.007451296,
-0.00017050437,
-0.012479902,
-0.020100854,
0.0005407788,
-0.012710635,
-0.016775595,
0.000011173444,
-0.01669416,
-0.010165793,
0.0017254025,
0.017481364,
-0.00353224,
0.012323819,
-0.00053399254,
-0.0015150289,
0.023331106,
-0.028665094,
0.014821157,
-0.036971457,
0.035505626,
0.028746529,
-0.0011663856,
-0.007268067,
-0.014441127,
0.0011587511,
-0.024036875,
-0.004088712,
0.024891943,
-0.028556515,
-0.0032947215,
-0.035939947,
0.020453738,
-0.033904076,
-0.0017762993,
-0.00033676735,
-0.030972417,
0.0012783586,
-0.0019442588,
0.008197783,
-0.035315614,
0.016762022,
0.029099414,
0.0032675765,
0.002171598,
0.012032011,
-0.03355119,
0.016015535,
0.03650999,
0.022177445,
-0.021960285,
-0.0001817441,
-0.016626297,
-0.011495897,
0.002546538,
0.004655363,
0.010233656,
-0.002933354,
-0.0045705354,
-0.035342757,
0.017874965,
0.009025704,
-0.0012698759,
-0.008469232,
-0.0048657367,
0.014495417,
-0.0027212838,
0.014929736,
0.004451776,
-0.03143388,
-0.007736318,
-0.0034253565,
0.013735358,
-0.024864797,
-0.017752813,
0.029723749,
0.005958322,
0.011231233,
0.0014836426,
-0.0013148347,
-0.0075530894,
0.007783822,
0.01396609,
-0.02079305,
0.009555032,
-0.000946681,
0.05078825,
-0.019001482,
-0.021145936,
-0.014766866,
-0.03127101,
-0.003759579,
0.040065985,
0.019164352,
-0.015431918,
0.018214278,
0.045983586,
0.038600154,
0.009894343,
-0.017535655,
-0.022299597,
0.019001482,
-0.00990113,
0.0043737344,
0.031732477,
-0.04861665,
0.013708212,
0.020535173,
0.011231233,
0.031108141,
-0.0043499824,
0.028610803,
-0.020331586,
-0.01920507,
0.0015608361,
0.01625984,
-0.0013988145,
-0.012595269,
-0.020535173,
0.022625336,
0.009093567,
0.0065758703,
-0.02428118,
0.021593828,
0.0126020545,
-0.015784804,
0.028230775,
0.012262743,
0.0015107875,
-0.004292299,
0.023534693,
0.015201186,
-0.008761041,
0.026819235,
-0.011937003,
-0.022177445,
0.0016482089,
0.002828167,
0.014196822,
0.023670418,
0.01833643,
-0.010036855,
0.005459533,
0.019354368,
0.0032353417,
-0.034582697,
0.02117308,
0.005361133,
-0.0045026727,
0.019761542,
0.021145936,
-0.010919066,
-0.010131862,
0.0037358273,
0.018892903,
-0.029995197,
-0.002809505,
0.0013623384,
0.04218329,
-0.0039869184,
0.012317033,
-0.008869621,
-0.0029655886,
-0.0059176045,
-0.021756697,
-0.042101856,
-0.02149882,
-0.016789168,
0.003759579,
0.032709695,
0.0076413103,
-0.016938465,
0.006474077,
0.030836692,
-0.011726629,
-0.0073562884,
-0.01309745,
-0.0038376208,
0.0009500741,
0.02641206,
0.013708212,
0.013117809,
0.030185213,
0.0010611989,
0.024634065,
0.009012132,
-0.02056232,
0.0138642965,
0.0056834794,
0.023493975,
-0.019354368,
0.00459768,
-0.012276315,
-0.017155625,
-0.022408176,
0.019652963,
-0.012330605,
-0.012608841,
0.079480484,
0.013321397,
-0.012778497,
0.023480404,
-0.020453738,
0.01631413,
0.0036917166,
0.009650039,
-0.016952038,
-0.020888058,
0.008944269,
0.016490573,
0.025339834,
-0.029452298,
-0.0074241506,
0.024796935,
0.01320603,
0.020657327,
-0.0035797437,
-0.036754295,
0.01396609,
-0.00984684,
-0.005340774,
0.0000592736,
-0.0017678165,
-0.009636466,
0.023656845,
-0.020358732,
-0.008598171,
-0.017006326,
0.0057140174,
0.009921488,
-0.024349043,
-0.006837141,
0.020155145,
-0.025407696,
-0.0046689357,
-0.035451338,
-0.015187614,
0.011407676,
-0.00706448,
0.0063858554,
0.0048589506,
-0.0075259446,
-0.017698525,
-0.013653923,
-0.002280178,
-0.0010459299,
-0.024729073
] |
OBJECTIVE To assay the efficiency for celiac disease (CD) screening of 2 immunochromatographic visual stick assays based on human recombinant tissue transglutaminase (tTG). One was the antitissue transglutaminase antibodies (AtTGA) stick for IgA/G antibodies to tTG detection, the other was the AtTGA/antigliadin antibodies (AGA) stick for IgA antibodies for tTG and/or gliadins. PATIENTS AND METHODS In a prospective multicenter study, 4 pediatric gastroenterology units from Spain and 2 from Latin America enrolled | [
-0.035062984,
0.014657033,
0.013443522,
-0.013572331,
0.0044540567,
-0.009769095,
-0.018426372,
-0.007375972,
-0.028880185,
-0.008847099,
0.023117706,
0.00088047277,
0.0061421236,
-0.0008147975,
-0.0060709403,
0.023049911,
0.032324113,
0.011531736,
-0.039727204,
-0.006118396,
-0.03389693,
0.0038134046,
-0.015741734,
-0.0017406073,
-0.011070738,
0.009504699,
0.033625755,
-0.043632127,
-0.017070495,
0.00684379,
0.0050980984,
0.0006563293,
-0.030615708,
-0.006864128,
-0.005952301,
-0.047401465,
-0.0027846328,
0.015118031,
0.026344694,
0.01910431,
-0.00064785505,
0.009565714,
0.0115046175,
-0.017463699,
0.003291392,
0.02638537,
-0.017734874,
-0.008725069,
-0.044445653,
0.0073285163,
0.002682942,
0.010026712,
-0.023321088,
0.0017541661,
-0.0080132345,
0.0030524186,
0.03357152,
0.02031104,
-0.009667404,
-0.039049264,
-0.020609334,
0.0073691923,
-0.021355066,
-0.00695565,
0.0018643312,
-0.00074361387,
-0.0031558042,
0.009857227,
-0.002416851,
-0.010094506,
0.014074005,
0.034086753,
-0.016107822,
-0.020066982,
0.037232388,
-0.0038032355,
-0.0031964805,
-0.020107659,
0.0013016422,
0.014521445,
0.02738872,
-0.004870989,
0.01953819,
0.042438958,
0.001677898,
0.018033167,
-0.013050318,
0.020392394,
-0.016650172,
-0.012968966,
-0.00894201,
0.030019121,
0.014060446,
0.022019446,
-0.013809609,
-0.00006345082,
-0.009809772,
0.048079405,
-0.018683989,
-0.01932125,
-0.0038066253,
-0.002308381,
0.014290946,
-0.019551748,
-0.0003853657,
-0.012121542,
0.005464185,
-0.0055150306,
-0.00084445724,
-0.019036517,
-0.012331703,
0.031754643,
-0.011721558,
-0.011335134,
-0.00088047277,
0.0043998216,
0.025843019,
-0.015714617,
-0.010087727,
-0.015457,
0.010833459,
0.01777555,
0.020229688,
-0.012779143,
0.029232712,
0.027632777,
-0.03332746,
0.00019978003,
-0.0101622995,
-0.013735036,
0.006748879,
0.009850448,
0.018345019,
0.003898147,
0.0038845881,
-0.008419997,
-0.019361926,
0.0044337185,
-0.0071929283,
-0.014657033,
0.012711349,
0.03367999,
-0.0034812146,
-0.012880833,
0.0010279244,
0.013789271,
0.0065760044,
0.02153133,
-0.00021418622,
0.016378997,
-0.027429396,
-0.01876534,
-0.018900927,
0.0064607547,
0.015958674,
0.019280573,
0.002484645,
0.010277549,
-0.03248682,
-0.01092837,
-0.025761666,
-0.008386101,
0.0040710215,
0.00043599925,
0.01776199,
0.03414099,
-0.013274037,
-0.0063963505,
0.027659895,
-0.0151722655,
-0.005562486,
0.030832648,
-0.030642824,
0.00651499,
-0.01037924,
-0.0021931313,
0.0025812513,
0.024283761,
-0.021816064,
-0.016541703,
-0.014873973,
0.035713807,
0.025029493,
-0.0073895305,
-0.0072403844,
-0.008413218,
0.0018185703,
0.041435607,
-0.0071183555,
-0.03766627,
0.010236872,
0.016745083,
0.020487305,
-0.010440255,
-0.6482178,
-0.018426372,
0.030480118,
-0.016433232,
0.020473745,
0.03457487,
0.025883695,
0.0039727204,
-0.027470073,
0.010853797,
0.018480606,
0.022426208,
-0.0042472854,
-0.013680801,
-0.020405952,
-0.043252483,
-0.009064039,
-0.016094262,
0.025720991,
0.016934907,
-0.018833134,
0.012609658,
0.003742221,
0.013274037,
0.01303676,
-0.0026659935,
0.014331622,
-0.011294457,
0.005386222,
0.02904289,
-0.018141637,
0.026792133,
-0.003467656,
0.019633101,
0.04723876,
-0.019741572,
-0.010108065,
0.0022439768,
0.004725232,
0.037259504,
-0.011836808,
-0.008955569,
0.022141475,
0.013836727,
-0.0069827675,
0.023212617,
0.0075047803,
0.024717642,
0.009836889,
-0.034900278,
-0.012941848,
0.004098139,
-0.013768933,
-0.0015168876,
0.025802342,
0.0029388638,
0.020107659,
-0.016717967,
0.013897741,
-0.0041489843,
-0.013429964,
0.024975257,
-0.0030795361,
-0.018019607,
-0.017789109,
-0.0020660178,
-0.000039458144,
0.01556547,
0.0047625187,
-0.0062573734,
0.018697547,
0.039293323,
-0.021138126,
0.015823087,
0.023321088,
0.010840238,
-0.00048176013,
0.0015219721,
-0.0005304869,
-0.010636857,
0.003401557,
0.012250351,
0.003455792,
0.02485323,
0.019565308,
-0.00281514,
-0.035062984,
0.011653764,
-0.006013315,
-0.0010550419,
-0.004789636,
0.01457568,
-0.014331622,
-0.035632454,
-0.020243246,
0.013497758,
-0.0340054,
0.022914324,
0.0062844907,
-0.016012909,
-0.019036517,
-0.016311202,
-0.005809934,
0.00751156,
0.0007275129,
0.012284247,
-0.04414736,
0.018941604,
0.04162543,
-0.031754643,
-0.0061828,
-0.010609739,
-0.024243085,
-0.02661587,
0.020189011,
-0.028636126,
-0.00084615214,
0.025449814,
-0.014602797,
-0.024446465,
0.01800605,
-0.012196115,
0.03918485,
0.00850135,
-0.0027320925,
0.006589563,
-0.009884344,
-0.036690038,
0.020026306,
-0.0066031218,
-0.019619543,
-0.0012923204,
0.007958999,
-0.013992652,
0.026358252,
0.0083725415,
0.024744758,
0.0039354335,
-0.025341345,
-0.04303554,
-0.02173471,
-0.013836727,
0.0021694035,
-0.008799643,
-0.008969127,
-0.00039956006,
0.0058777276,
0.009558934,
0.005430288,
0.0050065764,
0.0041930503,
0.007965779,
-0.010847017,
-0.00016270527,
-0.006667526,
-0.012616437,
-0.011802911,
-0.042818602,
0.017395904,
-0.013768933,
0.0057455297,
0.027470073,
-0.003179532,
-0.022399092,
-0.018711105,
0.0030524186,
-0.008481012,
0.020744922,
-0.018453488,
-0.028853066,
0.0032744433,
-0.027253132,
-0.014060446,
0.02991065,
0.012379159,
0.026222665,
-0.0040439037,
-0.016216291,
-0.010223314,
-0.014236711,
-0.010528387,
0.0023846491,
0.008257292,
0.0019863602,
0.03587651,
-0.007803073,
0.0062404247,
0.0052404655,
-0.0062878807,
0.028093776,
0.0036845962,
-0.0064878725,
-0.015646823,
0.0075929123,
-0.02085339,
-0.006643798,
0.0032930868,
0.011497838,
-0.0115046175,
0.0030049628,
0.019511072,
-0.016487466,
0.020270364,
-0.013016421,
0.023904115,
-0.018683989,
0.010013153,
-0.014494327,
0.02451426,
0.0066471878,
-0.00452524,
-0.022846531,
-0.0042981305,
0.00024532902,
0.0018931435,
0.02075848,
0.0061963587,
0.008772525,
0.012345262,
-0.011830028,
-0.0036913757,
0.02505661,
0.032839347,
0.00023134655,
-0.017707756,
0.022494003,
0.0059828083,
0.00182196,
-0.0024253253,
-0.017694198,
-0.02109745,
0.0032659692,
0.0005198942,
0.0027524307,
0.019307692,
-0.0010016543,
0.01291473,
0.0022727891,
0.02261603,
0.0183179,
0.003047334,
0.005545538,
0.00036121416,
-0.003277833,
0.006040433,
-0.024798993,
0.016690848,
0.020772038,
-0.008142043,
0.035035867,
0.014128241,
0.02097542,
-0.03674427,
0.0073827514,
-0.005908235,
0.014006211,
0.016826436,
-0.0039117057,
0.031537704,
0.03875097,
0.029395418,
0.011985955,
-0.0088199815,
-0.0062539834,
-0.012318145,
0.014250269,
0.002981235,
-0.023890557,
-0.019063633,
0.003477825,
-0.025192197,
-0.00884032,
0.025382021,
-0.0183179,
-0.009647066,
0.024419349,
0.014128241,
-0.022127915,
0.021680476,
0.011694441,
-0.024582053,
-0.027619218,
0.028988654,
0.002196521,
-0.007742059,
-0.021273714,
0.004616762,
-0.015701057,
-0.021327948,
-0.0015694279,
0.0083725415,
0.024893906,
0.028961537,
-0.004460836,
0.013829947,
0.008487791,
0.03465622,
-0.01688067,
-0.0074708834,
0.009294538,
0.013152009,
-0.019795807,
-0.007253943,
-0.008880995,
0.011226663,
0.036906976,
-0.030398767,
-0.0075657945,
0.0074776625,
-0.0014168917,
0.005948911,
0.003908316,
-0.008711511,
0.007030223,
0.006270932,
0.008121705,
-0.015728176,
-0.0009516563,
0.011741896,
-0.012182557,
-0.027619218,
-0.038561147,
-0.0043896525,
0.013558772,
0.010894474,
0.023361765,
-0.00075717265,
0.0032320723,
0.019294132,
0.0067963344,
-0.008914893,
-0.028581891,
0.018236548,
-0.002086356,
-0.013558772,
0.0083725415,
0.017355228,
-0.001197409,
-0.002559218,
0.018087402,
-0.0038066253,
-0.011247002,
0.011708,
0.028066657,
0.01919922,
0.007199708,
0.015728176,
0.012094424,
0.023985468,
-0.033002052,
0.0095318165,
0.019131428,
-0.0022338077,
-0.018155195,
-0.01622985,
0.0015406155,
0.008447115,
0.012019851,
-0.021504212,
-0.02151777,
0.015036678,
-0.0004018905,
-0.00027922596,
-0.01247407,
0.017300993,
0.00040633944,
0.0027541255,
0.011619868,
-0.0056099417,
-0.0048675993,
0.005145554,
0.015185825,
-0.028175129,
-0.031076705,
0.020378834,
-0.008528467,
0.004891327,
-0.012602879,
0.015524793,
-0.00032731722,
-0.025531167,
0.00012902019,
0.019239897,
-0.01678576,
0.005898066,
-0.010731768,
-0.010128403,
-0.0038506913,
-0.029395418,
-0.031158058,
-0.017382346,
-0.025598962,
-0.02671078,
0.0025659977,
-0.013335052,
-0.024161732,
-0.014385857,
0.0072064875,
0.0026117584,
0.0016262052,
0.0036913757,
0.003986279,
0.0056099417,
0.025368461,
-0.014412975,
-0.018263666,
0.004613372,
-0.02915136,
0.008725069,
-0.0015872237,
0.02615487,
-0.024554936,
-0.003959161,
0.007911543,
-0.012182557,
-0.004548968,
-0.004372704,
-0.0010643636,
0.0012838462,
-0.00529809,
0.015755294,
0.015863763,
-0.0231855,
-0.012318145,
-0.028283598,
-0.025815902,
-0.0021372014,
-0.016867112,
0.012602879,
0.010033491,
-0.019836484,
-0.015917998,
-0.008623379,
-0.017084053,
-0.010494489,
0.005508251,
-0.012704569,
-0.013314714,
0.0074166483,
0.015741734,
-0.0041150874,
0.007938661,
0.0063217776,
-0.0051082675,
-0.022982119,
0.0018016219,
0.029992003,
0.0039286544,
-0.028229363,
0.019633101,
0.011626647,
-0.018141637,
0.00014543901,
-0.022778736,
-0.027754806,
0.018670429,
0.009070818,
-0.0057251914,
-0.020677127,
-0.015877321,
-0.016514584,
0.017626403,
0.000251261,
-0.015741734,
-0.00008717867,
0.011511398,
0.019158544,
0.006084499,
0.0005588756,
-0.034385044,
0.005474354,
0.03468334,
-0.019646661,
0.030290296,
0.015511235,
0.006606512,
-0.02273806,
-0.0062302556,
-0.021626242,
-0.018155195,
-0.00883354,
0.012175777,
0.01479262,
0.027036192,
0.05344868,
0.015728176,
0.0039557717,
-0.0019287353,
0.0012855411,
0.020785598,
-0.002340583,
0.011972396,
0.0052302964,
-0.0049387827,
0.021463536,
-0.027212456,
0.0053963913,
-0.037693385,
-0.009186068,
0.0010889389,
-0.01766708,
-0.014223152,
-0.0026626037,
-0.043523658,
-0.010704651,
-0.00673193,
0.009070818,
0.026195547,
-0.030886883,
-0.006901415,
0.039022144,
0.013274037,
0.026561635,
0.0061217854,
0.03500875,
-0.008236954,
0.012602879,
0.0041116974,
-0.000493624,
0.011680882,
-0.04116443,
-0.0040235654,
-0.0065760044,
0.022955,
0.023375323,
0.00629466,
-0.0052641933,
-0.01445365,
-0.008365762,
0.0022253334,
-0.008772525,
0.008128484,
-0.010372461,
-0.022426208,
-0.024676966,
-0.008704731,
-0.016094262,
-0.019850042,
0.0026524349,
0.0032439362,
-0.034059636,
0.01027077,
-0.026087077,
-0.008379321,
0.0074437656,
-0.006426858,
0.049055636,
-0.018372135,
0.0049997973,
0.03191735,
0.0023236345,
-0.035442628,
-0.011226663,
0.007023444,
-0.00096182537,
0.012372379,
0.03332746,
0.0010906337,
-0.016067145,
0.005728581,
0.015104472,
-0.013124892,
-0.03302917,
0.016134938,
0.016148498,
-0.009084377,
-0.033273228,
-0.018331459,
-0.025856579,
0.034710456,
-0.00020740683,
0.0015618011,
-0.01148428,
-0.0016465434,
-0.02075848,
0.03367999,
-0.02405326,
0.034601986,
0.012277468,
-0.014033329,
0.005359105,
-0.035822276,
-0.012209674,
0.0006639561,
0.021111008,
0.016311202,
-0.0044879536,
0.0068505695,
-0.0019168714,
0.008203057,
0.0027914122,
-0.008481012,
0.0031151278,
0.033490166,
-0.0010719904,
-0.009775874,
0.014724826,
0.0057014637,
0.0034693507,
0.0027625998,
-0.00082962733,
-0.006084499,
-0.028636126,
-0.014168916,
0.023524469,
0.0058573894,
-0.020894067,
0.01899584,
-0.018792458,
0.011084296,
-0.019239897,
-0.030697059,
0.027619218,
-0.032432582,
-0.0033676599,
0.017246759,
0.013721477,
0.001966022,
0.019714454,
0.018697547,
-0.0028625957,
0.023524469,
-0.03742221,
0.01126734,
0.01148428,
0.0007190386,
0.008148822,
0.0063421153,
-0.01599935,
-0.02661587,
0.011640206,
0.008155601,
-0.015253618,
-0.035062984,
0.015375648,
0.0022778737,
0.00993858,
-0.018263666,
0.0021999108,
0.0051930095,
0.0278226,
-0.007084458,
-0.017490815,
0.013850286,
-0.020460187,
-0.002284653,
0.01919922,
0.011355472,
-0.0017660301,
0.022507561,
-0.00983011,
-0.0143722985,
-0.014426533,
-0.02252112,
-0.025137963,
0.02860901,
-0.02395835,
0.013443522,
-0.006128565,
-0.0018287394,
0.0041930503,
-0.010006374,
-0.0015287516,
-0.010277549,
-0.017856903,
-0.0050269146,
-0.009667404,
0.030453002,
-0.010060608,
0.0033066454,
-0.008304748,
-0.008616599,
-0.04083902,
-0.012982524,
-0.022466885,
0.022710944,
0.011199546,
-0.0054946924,
-0.018412812,
-0.0005198942,
-0.020826275,
-0.0019592426,
-0.008582703,
0.015701057,
0.015185825,
0.013050318,
-0.0071793697,
0.033137638,
-0.020839833,
0.01999919,
-0.0148197375,
-0.022168592,
0.025639638,
-0.017612845,
0.0139113,
0.017029818,
-0.032378346,
-0.018792458,
0.018724663,
0.0006165004,
-0.01590444,
0.018643312,
0.0042472854,
0.014209593,
-0.020256806,
0.009667404,
-0.025463374,
0.0016711187,
-0.00025147284,
-0.009247082,
-0.0019626322,
0.00076691806,
-0.01126734,
0.016067145,
-0.017273875,
0.0091792885,
0.0069488706,
0.008386101,
-0.03126653,
-0.019768689,
0.016501026,
-0.004548968,
-0.0008270851,
0.025937932,
-0.0019422941,
0.007606471,
0.015145148,
0.0009067429,
0.003191396,
-0.009287759,
-0.02020257,
0.0041489843,
0.011972396,
-0.030968236,
0.0063760127,
0.00806069,
-0.015579029,
-0.0007512407,
0.00022689758,
-0.00063853344,
-0.0071047964,
-0.037774738,
0.006898025,
0.023714293,
0.011931719,
-0.0091792885,
0.015240059,
-0.011613088,
0.004593034,
-0.007484442,
-0.008114925,
-0.008250513,
-0.013613007,
-0.020595774,
-0.015429882,
0.0071590315,
0.002859206,
-0.016867112,
-0.019944953,
-0.018236548,
0.19394468,
-0.014236711,
-0.010175859,
0.0074912217,
-0.015226501,
-0.008935231,
0.022100799,
0.0020185623,
-0.0134774195,
0.030290296,
0.027903952,
-0.018955164,
0.0029015772,
-0.0011906297,
-0.00031375844,
-0.013599448,
-0.03877809,
-0.019158544,
0.0047184527,
-0.015063795,
0.04628965,
-0.001143174,
0.01203341,
-0.007599692,
0.02671078,
-0.01490109,
0.0039794995,
0.02065001,
0.024554936,
0.0044574463,
-0.019511072,
0.02119236,
0.0062641525,
0.008020014,
-0.015524793,
-0.0006054839,
-0.01490109,
-0.004870989,
0.0041049183,
0.020527981,
-0.023673616,
-0.0017711145,
-0.018250108,
-0.0066641364,
-0.019768689,
0.008175939,
-0.01115887,
-0.0072607226,
0.007165811,
0.01092837,
-0.020894067,
-0.0033269837,
0.006304829,
0.031510588,
0.005552317,
-0.005020135,
0.027361602,
-0.01158597,
0.00028028523,
0.030968236,
-0.007640368,
0.0030964846,
-0.025992166,
0.03720527,
-0.009925021,
0.021965211,
-0.015240059,
0.00055379106,
-0.005135385,
-0.008487791,
0.02054154,
-0.028120892,
-0.006931922,
0.013633345,
-0.025097286,
-0.005918404,
0.024310878,
0.021124566,
0.001335539,
0.021233037,
-0.001275372,
0.024337996,
-0.024351554,
0.0008211531,
-0.032296997,
-0.012663893,
0.020243246,
0.014724826,
-0.013260479,
-0.0027354823,
-0.013951976,
-0.01170122,
-0.014060446,
-0.0032524103,
0.0026253173,
0.0054268986,
0.0037930664,
-0.017423023,
0.012230013,
-0.0133011555,
-0.017029818,
0.06535328,
-0.029964887,
0.015294295,
-0.026412487,
0.019185662,
-0.041977957,
-0.008853878,
0.008935231,
-0.00529809,
0.019782249,
-0.03411387,
-0.0030100474,
-0.011063958,
-0.008697952,
0.029314065,
0.017531492,
-0.0062200865,
0.003843912,
-0.009321656,
0.01797893,
-0.0077217207,
0.007538677,
0.009199627,
-0.02947677,
-0.0024998987,
-0.021653358,
-0.006562446,
0.016284086,
-0.027320925,
-0.02063645,
-0.009403008,
0.014087564,
0.019890718,
0.00039341624,
-0.00275921,
-0.0026422658,
-0.011843587,
-0.03579516,
0.006016705,
0.0061082267,
-0.0063895714,
-0.00959961,
-0.007030223,
0.02715822,
-0.016853554,
0.010114844,
0.018141637,
-0.03522569,
-0.010623298,
-0.018629752,
-0.02252112,
-0.007145473,
0.00816916,
0.0009414872,
0.002506678,
-0.0015389206,
-0.02869036,
0.028337833,
-0.01666373,
-0.0145485625,
0.0073895305,
0.035252806,
0.019144986,
0.001799927,
0.015375648,
-0.17322686,
0.019850042,
0.012324924,
-0.034059636,
0.026737899,
0.00018897538,
0.013979094,
0.021490654,
-0.004711673,
-0.001193172,
0.019687336,
-0.008020014,
-0.035252806,
0.0029456432,
-0.002064323,
-0.014860414,
-0.042276252,
0.029232712,
0.016582377,
-0.002416851,
0.019917836,
-0.017043376,
-0.0045760856,
-0.020121217,
0.0002641842,
0.026995515,
0.00073175,
-0.010874135,
-0.011531736,
0.002727008,
-0.009409788,
0.007145473,
0.04341519,
0.010460593,
-0.005531979,
0.0029676761,
0.0018151806,
-0.0051692817,
-0.00095758826,
0.0055692657,
0.029747946,
0.026480282,
0.0063895714,
-0.0066844746,
-0.01633832,
0.0156875,
0.014019771,
-0.023307528,
0.034195222,
-0.020731362,
0.02692772,
-0.0200941,
0.031483468,
0.014507886,
0.013701139,
0.00092284393,
0.006823452,
0.032025818,
0.033924047,
0.012894392,
-0.0046540485,
-0.015863763,
0.01941616,
-0.007457325,
-0.016378997,
-0.04547612,
-0.019931395,
-0.0073352954,
0.0136536835,
0.0024998987,
-0.015362089,
-0.0055251997,
0.0018100961,
-0.036391743,
0.027849717,
0.008955569,
-0.033869814,
0.0070708995,
0.021666918,
-0.022426208,
-0.014765503,
0.000110059096,
-0.021016097,
0.0057692574,
-0.012128321,
0.0011728337,
0.0053624944,
0.020066982,
-0.023266852,
0.010799562,
0.030073356,
-0.011762234,
-0.015240059,
-0.020175453,
0.000041735595,
0.030154709,
-0.0156875,
0.012596099,
0.014060446,
-0.010291108,
0.011213104,
-0.025354903,
-0.028175129,
0.004942172,
0.01059618,
0.0021100838,
-0.012338483,
0.0011635121,
0.02429732,
0.00751156,
-0.02904289,
0.029422535,
0.012541864,
0.018846693,
-0.00022456716,
0.03677139,
-0.0130232,
0.0017863682,
-0.00048387868,
-0.01191816,
0.041137315,
-0.002937169,
0.016012909,
0.008108146,
-0.018751781,
-0.0028049708,
-0.1196426,
-0.024188848,
0.008799643,
0.012155439,
-0.008419997,
-0.007626809,
0.0028286988,
0.007775956,
0.0034405384,
0.031103823,
-0.02549049,
-0.012074087,
-0.030019121,
-0.024256643,
0.016080704,
0.03289358,
0.0070505613,
-0.020283923,
-0.019578867,
0.02683281,
-0.0027575153,
0.0041591534,
0.0039184853,
-0.011247002,
-0.030317415,
-0.007897984,
-0.019267015,
0.033815578,
0.013402846,
0.03587651,
-0.016216291,
0.0021897417,
0.012087645,
-0.017382346,
-0.022914324,
-0.0075929123,
-0.024432907,
-0.02021613,
0.0289073,
0.02143642,
-0.0035185013,
0.009843668,
0.00027583627,
-0.0041252566,
0.019646661,
0.011972396,
-0.010887694,
-0.0059014554,
0.006942091,
-0.03487316,
0.010630077,
-0.033435933,
-0.013450302,
-0.0064234682,
0.0096267285,
0.0039557717,
0.019307692,
0.001429603,
-0.012514747,
-0.011321574,
0.0141011225,
0.0042235577,
-0.019714454,
0.00905048,
0.036364626,
0.013714698,
-0.021395743,
-0.018494165,
0.0024693913,
-0.0054506264,
-0.0018338239,
0.0002737177,
-0.011436824,
-0.024826111,
-0.0024998987,
0.0092674205,
-0.0077217207,
-0.010209755,
-0.00060167053,
-0.028880185,
-0.010108065,
-0.019470397,
0.010141961,
0.0055590966,
0.031781763,
-0.010908032,
-0.00331173,
-0.014480769,
0.0025321008,
-0.03487316,
-0.009802992,
0.030859765,
0.019063633,
-0.008114925,
-0.013884182,
0.025368461,
-0.014779061,
-0.010901253,
0.019687336,
0.0030303856,
-0.023700733,
-0.01721964,
-0.06589563,
0.0008211531,
0.018467048,
-0.00037964561,
0.0071047964,
-0.012996083,
0.012731687,
-0.013185905,
0.011836808,
-0.0123994965,
-0.022371974,
0.00871829,
-0.015294295,
0.022358416,
-0.011355472,
-0.011497838,
0.032188524,
0.011992734,
0.028798832,
0.038859442,
-0.0020965252,
0.005904845,
0.0008249665,
0.03378846,
0.011233442,
0.012433394,
-0.039401792,
0.016826436,
-0.0032100393,
-0.0028219195,
0.018833134,
-0.014955325,
0.00055379106,
0.0042574545,
0.0017194217,
-0.0055692657,
-0.007233605,
0.024270201,
0.0185484,
0.007321737,
-0.003335458,
-0.03631039,
0.011423266,
0.008304748,
-0.016324762,
-0.0031202124,
-0.03302917,
0.024676966,
0.019226339,
0.0033269837,
0.034601986,
0.010080947,
0.022358416,
-0.01876534,
-0.00695565,
-0.003555788,
0.017246759,
-0.011463942,
0.0015185825,
-0.0023541418,
0.055102848,
-0.007891205,
0.009199627,
0.0062539834,
0.001341471,
-0.004948952,
-0.022033004,
-0.02085339,
0.005464185,
-0.009409788,
-0.019904276,
0.012135101,
-0.01014874,
0.027578542,
0.0118639255,
0.0072946195,
-0.015850205,
0.010541945,
0.012826598,
0.019646661,
-0.008935231,
0.0030710618,
-0.0072064875,
0.048296347,
0.0093555525,
0.006386182,
0.0037456108,
0.030154709,
-0.0055285892,
0.0013584194,
-0.0026863317,
0.029449653,
-0.002825309,
-0.015701057,
-0.0021846571,
0.015131589,
0.007518339,
0.0062539834,
0.02485323,
0.03587651,
0.0019168714,
-0.002981235,
-0.008962348,
0.0018389084,
-0.0036303613,
0.009416567,
-0.032839347,
-0.037584916,
-0.00090250577,
-0.017382346,
0.011430045,
-0.014928208,
0.004772688,
-0.0022117747,
-0.019592425,
-0.0043523656,
-0.012189336,
0.013111332,
-0.015375648,
0.00242702,
0.006104837,
0.018345019,
-0.00015020577,
-0.0069217533,
0.001996529,
-0.009301318,
0.022561796,
-0.03389693,
0.029015772,
-0.003586295,
0.0018117909,
0.0043252483,
-0.0026320966,
-0.015646823,
0.008121705,
0.0059014554,
0.010806342,
0.009796212,
-0.042140663,
0.10131115,
0.010528387,
-0.0019507683,
0.011091076,
0.00081818714,
0.013179126,
-0.0024439686,
0.0025202367,
-0.017653521,
-0.016812878,
-0.0049964073,
-0.006128565,
0.022439767,
-0.031537704,
-0.0324597,
0.011735117,
-0.0074776625,
-0.0026744679,
-0.015226501,
-0.021368625,
0.017463699,
-0.029395418,
0.005952301,
0.0042744027,
0.0046777762,
0.0017372177,
0.017423023,
0.0038371324,
-0.015606146,
-0.023565145,
0.00068726024,
0.0028863235,
-0.039347555,
-0.013409626,
0.0044303285,
-0.03414099,
-0.011653764,
-0.0057353606,
0.014155358,
0.019294132,
0.013375728,
0.038371325,
-0.024554936,
0.011165649,
-0.019172104,
-0.04059496,
-0.021707594,
-0.015158707,
-0.0039049264
] |
AIMS This study aimed to identify relevant keratin subtypes that may associate with the pathogenesis of oral epithelial neoplasms. METHODS AND RESULTS Expression of all the keratin subtypes was examined by cDNA microarray analysis of 43 oral squamous cell carcinoma (OSCC) cases. Immunohistochemical expression of the major keratins was examined in 100 OSCC and oral epithelial dysplasia (OED) cases. Many changes in keratin expression were observed and, significantly, consistent down-regulation of keratin 4 (K4) and K13 expression was observed. Aberrant expression | [
-0.010999638,
0.008758373,
0.015320693,
-0.02379487,
-0.024466604,
0.0125691695,
-0.0032860045,
0.011903894,
-0.019299423,
0.004240318,
0.0072986437,
-0.01136134,
0.004027172,
0.01653498,
-0.026094267,
0.015695313,
0.027851108,
-0.020061582,
-0.012175172,
0.0017665302,
-0.048338983,
0.009985578,
-0.019841976,
-0.014933155,
-0.01723255,
0.023032712,
-0.0005958406,
-0.042164203,
-0.019906567,
-0.02329107,
0.027566914,
0.009514073,
-0.0122655975,
0.017142124,
-0.020113254,
0.019557782,
0.0042467774,
-0.012084746,
0.014248503,
-0.005593474,
-0.011219243,
-0.010696066,
0.0070596617,
-0.024892896,
0.0046117096,
0.0015654946,
0.023278153,
-0.011974943,
-0.021727998,
0.026430134,
-0.0056645228,
0.02190885,
-0.0121235,
-0.0052737547,
0.008202901,
-0.001297447,
0.029427098,
-0.000520755,
-0.015165678,
-0.0122655975,
0.01515276,
0.0148556465,
-0.013563852,
0.016057016,
0.00081221637,
0.0062910435,
-0.009384894,
0.020797906,
0.008958601,
-0.00884234,
0.047563907,
0.026184693,
-0.02455703,
-0.0028064256,
0.03332832,
-0.013589688,
-0.00972076,
-0.015514462,
0.0089133885,
-0.0041692695,
0.009520532,
-0.0031406775,
-0.012905036,
0.003516913,
-0.0043856455,
0.013066511,
0.008745455,
0.01824015,
0.0078476565,
0.01464896,
-0.0012045992,
0.02241265,
0.012646677,
-0.0045632673,
-0.04198335,
0.042706754,
0.007821821,
0.03844383,
0.00031346222,
-0.032114033,
-0.006704418,
0.009003813,
0.0007448008,
-0.015243186,
-0.023769036,
0.012207466,
0.009824104,
0.006497731,
0.022296388,
-0.012368941,
-0.01395139,
0.028083632,
0.01003725,
-0.031054761,
0.021986358,
-0.017749269,
0.011471143,
0.005625769,
-0.029633787,
-0.0044663823,
-0.014170995,
0.027566914,
0.005561179,
-0.036325287,
0.031338956,
0.011568028,
-0.027179375,
-0.02215429,
-0.017968874,
-0.013118182,
0.034077562,
0.011903894,
0.03201069,
-0.0042209416,
0.009746596,
-0.011102981,
-0.024285752,
-0.002512542,
-0.009397811,
-0.030796401,
0.0068206796,
0.02834199,
0.0051025916,
0.0074019874,
-0.005670982,
0.010883376,
0.025706729,
-0.009959742,
0.017000027,
0.019699879,
0.0012288204,
-0.009081322,
0.01010184,
-0.0055967034,
0.025409615,
-0.004027172,
0.05327364,
0.022838943,
-0.039063893,
0.0016365433,
0.000056112363,
-0.0093267625,
0.0041951053,
0.026339708,
0.009339681,
0.010935048,
0.029272083,
0.018162644,
-0.0016970962,
-0.020694561,
-0.020617055,
0.0029743589,
-0.036402795,
0.011600322,
0.007582839,
-0.007892869,
0.007066121,
0.02468621,
-0.029582115,
-0.033224978,
-0.0126143815,
0.02947877,
0.012045992,
-0.00083320803,
-0.023019794,
0.0006656783,
0.0007351123,
0.009158829,
-0.021676326,
-0.010140594,
0.0143776825,
0.014416437,
-0.0021879785,
-0.01003725,
-0.63701016,
-0.049889136,
0.008034967,
0.0023769035,
0.018227233,
0.028135303,
0.0148556465,
-0.00071775384,
-0.014726467,
0.00467307,
-0.026481805,
-0.012711267,
-0.010663771,
-0.001868259,
-0.010302068,
-0.043636847,
-0.010489378,
-0.023187727,
0.01679334,
-0.014545616,
-0.02986631,
-0.009920988,
0.0012772627,
0.02816114,
-0.0010189036,
0.022063864,
0.011348423,
-0.04994081,
0.0051187393,
0.026184693,
-0.047693085,
0.013421754,
0.0047634956,
0.00441794,
0.0551855,
-0.0039496645,
-0.025409615,
0.0074084466,
0.015062334,
0.0592159,
0.0099791195,
-0.01768468,
0.018149724,
-0.0004141819,
-0.030899746,
0.0364803,
0.016845012,
0.013628441,
0.009158829,
-0.0032052672,
-0.010250396,
-0.0056968178,
-0.030848073,
-0.010993179,
0.041053258,
-0.01793012,
0.032656588,
-0.021702163,
0.010702524,
0.01786553,
0.011710125,
0.023807788,
-0.019777387,
-0.028936217,
0.0035459783,
0.037849605,
-0.0021443802,
0.0039916476,
0.016082853,
0.008041427,
0.008861716,
0.044489432,
0.0014250118,
0.016237868,
0.018046381,
0.050354183,
-0.0020943233,
-0.0033360615,
-0.003775272,
-0.021262951,
0.01408057,
-0.0017649154,
-0.015759904,
0.012769397,
0.016044099,
-0.0024931652,
-0.02020368,
0.018098053,
-0.0034749296,
-0.0051671816,
0.024389097,
-0.0010084078,
-0.0055547203,
-0.030977253,
-0.0096109575,
0.01641872,
-0.0023704446,
0.00561931,
-0.017155042,
-0.036325287,
-0.004857151,
-0.012582087,
-0.010708984,
-0.0020361925,
0.01149052,
-0.0014605362,
-0.017322976,
-0.00008416854,
0.029917981,
-0.023575265,
0.012110582,
0.02114669,
0.013615523,
-0.032398228,
-0.008532309,
-0.028419498,
0.012556251,
0.0060649794,
-0.01224622,
-0.026223447,
0.010721901,
-0.013796375,
-0.0007472229,
-0.027101867,
0.015475709,
-0.0066979593,
-0.012452908,
-0.00782828,
0.012982544,
-0.019829059,
0.0032149558,
-0.029892145,
-0.0041951053,
-0.010928589,
0.011813469,
0.0014653804,
0.035653554,
-0.008441883,
-0.012104123,
-0.034671787,
-0.008596898,
-0.011509897,
0.0059487177,
-0.00088003563,
-0.007938082,
0.0049378877,
-0.023523593,
0.0018440379,
0.020513711,
0.005922882,
-0.004976642,
-0.017723432,
-0.00059261115,
0.0052188532,
0.014300175,
-0.0112644555,
-0.010095381,
-0.0038721566,
0.009003813,
-0.008726078,
-0.012394777,
0.013538016,
-0.022218881,
-0.0017245469,
0.0079122465,
-0.0034426346,
-0.01521735,
0.02064289,
-0.006523567,
-0.027050195,
-0.0066010742,
-0.010747737,
-0.005151034,
0.010592722,
-0.017645925,
-0.0038204847,
-0.009365517,
-0.0068465155,
-0.006523567,
-0.000035726214,
0.009669089,
-0.032114033,
-0.004301679,
-0.0073890695,
0.025086666,
0.029633787,
0.04810646,
-0.0011133661,
0.017878449,
0.03888304,
-0.0103731165,
0.009255714,
-0.019674044,
0.024828307,
0.0133959185,
-0.018149724,
0.032294884,
0.000050233684,
0.009636793,
0.019105654,
0.023433167,
-0.034077562,
-0.0030906205,
-0.0046569225,
0.01641872,
-0.0049217404,
-0.007311562,
-0.010644394,
0.02159882,
0.0012586932,
0.020733315,
0.02090125,
-0.01849851,
0.004944347,
-0.0037462066,
0.0036525514,
-0.017077535,
-0.020423286,
-0.02008742,
-0.02121128,
-0.022193044,
0.0330958,
0.023523593,
-0.003503995,
-0.0039755004,
0.019984074,
0.015540298,
0.0048765275,
0.016935438,
0.003675158,
-0.024169492,
0.0046052504,
0.016767504,
-0.01812389,
0.029840473,
0.0031277596,
0.018898966,
-0.014597287,
0.025848826,
-0.019958239,
-0.0060326844,
0.017348813,
-0.00010097198,
0.0031697429,
-0.0011747264,
-0.033819202,
0.02733439,
0.0029065397,
-0.008222277,
0.015669478,
0.011206325,
-0.0034297167,
-0.0116778305,
-0.000603107,
-0.009933907,
-0.0023462235,
0.0001346293,
0.031597316,
0.034103397,
0.010818786,
0.0051994766,
-0.0190669,
0.023523593,
-0.0076022157,
0.008771291,
0.024298672,
0.008971519,
-0.0021476098,
-0.016586652,
-0.014326011,
-0.02064289,
0.0057161944,
0.01767176,
-0.050612543,
-0.012659594,
0.018976474,
-0.0084354235,
0.019105654,
0.016431637,
0.031468134,
-0.016341211,
-0.016922519,
0.011884518,
0.010728361,
-0.0031778167,
0.00536741,
-0.010883376,
-0.0068142205,
-0.010231019,
0.017658843,
0.019971156,
0.020410366,
0.0031261449,
-0.0049992483,
-0.01149052,
-0.003503995,
0.022490157,
-0.020397449,
0.013370082,
-0.0064234524,
-0.010392494,
-0.021650491,
-0.006646287,
-0.0021411509,
0.054875467,
0.014571452,
-0.0024108132,
-0.005971324,
-0.035834406,
-0.0037300591,
-0.00959804,
-0.008344999,
-0.031648986,
0.005109051,
-0.005409393,
-0.009908071,
0.011865141,
0.0013515409,
0.043533504,
0.0014936384,
-0.0020749464,
-0.02449244,
-0.012052451,
0.0016551128,
0.0054449174,
0.02720521,
-0.0024544112,
0.018847294,
0.026766,
-0.0020571842,
-0.009397811,
-0.029814638,
0.00084289646,
-0.01711629,
-0.015372365,
0.0041821874,
0.016121607,
-0.004786102,
0.027256882,
0.007776608,
-0.0021912078,
-0.006329797,
-0.024466604,
0.010347281,
-0.012607923,
-0.0038624683,
0.02146964,
0.057924107,
0.024402015,
-0.015591971,
0.011903894,
0.029272083,
-0.0059196525,
-0.019338178,
-0.009191124,
0.043921042,
0.010140594,
0.025241682,
-0.0020507253,
-0.03371586,
0.023058547,
-0.004488989,
-0.008299786,
-0.009966201,
-0.0027612126,
0.006087586,
0.008377293,
-0.005832456,
-0.015424036,
-0.0099145295,
0.008881093,
0.015811576,
-0.009753055,
-0.019105654,
0.004766725,
-0.012407695,
0.010928589,
-0.017943038,
0.015837412,
0.013014838,
-0.008022049,
-0.0058744396,
0.0012506194,
-0.02103043,
0.009003813,
-0.0005962443,
0.0068981876,
-0.0027676716,
-0.026029676,
-0.008280409,
-0.0072534312,
-0.014274339,
-0.030047162,
-0.013796375,
0.034361757,
-0.016754586,
-0.03420674,
-0.0031745872,
0.0026804754,
0.02537086,
0.018110972,
-0.016044099,
0.01193619,
0.0072405133,
-0.013240903,
-0.0076280516,
-0.0013919096,
-0.015488626,
-0.0012255908,
0.0042500068,
0.0011060998,
-0.007944542,
-0.014726467,
0.012213925,
0.0026804754,
0.009145911,
-0.0125045795,
-0.0032924635,
-0.0024350344,
0.0004123653,
0.01616036,
0.030641386,
-0.025835907,
-0.020436203,
-0.0035588962,
-0.034749296,
-0.010831704,
-0.02816114,
-0.018718116,
-0.021198362,
-0.0072405133,
0.017645925,
-0.0195707,
-0.009759514,
0.0070854975,
-0.021895932,
0.0051639522,
0.0013773768,
0.008784208,
0.015475709,
-0.02241265,
0.028497007,
0.00010258672,
0.014816893,
0.00656555,
-0.011574486,
0.026016759,
0.009488237,
-0.011716584,
0.022360979,
-0.008170606,
-0.02008742,
-0.017633008,
-0.022877697,
-0.019364012,
0.02537086,
-0.01268543,
-0.028832873,
0.0072986437,
0.0052414597,
-0.0031552103,
0.007544085,
0.014946072,
-0.009992037,
-0.00096238754,
0.008293326,
0.005486901,
0.007382611,
0.01887313,
-0.026610985,
-0.015436955,
0.029272083,
0.001616359,
-0.0076345108,
-0.013731785,
0.025848826,
-0.001089145,
-0.006413764,
0.016741669,
-0.025461286,
0.01975155,
-0.0043533505,
0.035782732,
0.025047913,
0.04771892,
0.0021314623,
0.034749296,
0.027618585,
-0.000005184843,
-0.006591386,
-0.027437733,
0.0033812744,
-0.017581334,
-0.008170606,
0.011432389,
-0.017529663,
0.030150505,
0.0017762186,
0.015462791,
0.020952921,
-0.00814477,
-0.010069545,
0.006003619,
-0.02311022,
-0.03454261,
0.0026061973,
-0.018911885,
0.015307776,
-0.03536936,
0.024285752,
0.0052511482,
0.019118572,
-0.015062334,
-0.015772821,
0.032114033,
-0.0018359642,
0.034826804,
-0.010747737,
0.003024416,
-0.0052188532,
-0.0036525514,
0.0012506194,
-0.01938985,
0.021482557,
0.006129569,
0.035756897,
0.002475403,
-0.01736173,
-0.012930872,
0.016819175,
-0.0035007654,
-0.011122358,
0.007505331,
-0.012588546,
-0.023032712,
-0.02090125,
-0.02582299,
-0.019105654,
-0.003939976,
0.015708232,
-0.01596659,
0.022012193,
-0.009249255,
-0.0068723513,
0.02639138,
-0.013215067,
0.028497007,
-0.037591245,
0.023136055,
-0.00035867505,
-0.020526629,
-0.022193044,
0.017374648,
0.002657869,
0.0005607199,
0.02519001,
0.03017634,
0.012343105,
-0.0051316572,
-0.016922519,
-0.0066204513,
-0.0063717808,
-0.041750826,
0.01698711,
0.007834739,
0.008622734,
-0.0069692363,
0.017620089,
-0.026688492,
0.025797153,
-0.016586652,
-0.016121607,
-0.014571452,
-0.003578273,
-0.022942286,
0.019841976,
-0.0066656643,
0.019777387,
0.026133021,
-0.014842729,
-0.025138339,
-0.03704869,
-0.010708984,
-0.00030559034,
0.0086291935,
0.008525849,
-0.00902965,
0.007621593,
0.013305493,
-0.008894011,
0.0060811266,
-0.009229878,
-0.016870847,
0.03668699,
-0.004873298,
-0.009811186,
-0.0062490604,
0.0014936384,
0.0018133578,
0.0009995267,
-0.00015511637,
-0.015411119,
-0.047693085,
-0.0031229153,
0.03536936,
0.01742632,
0.02064289,
0.0075247083,
-0.030383028,
0.0028645562,
-0.013383,
-0.015682396,
0.009772432,
-0.04609126,
-0.025151256,
-0.0032052672,
0.0074084466,
0.008874634,
0.024724964,
-0.013357164,
0.004508366,
0.022890614,
-0.004237089,
0.0046052504,
0.031855673,
0.0019118572,
-0.0018262757,
0.010831704,
-0.01824015,
-0.0458329,
0.028807037,
-0.029375426,
-0.024763718,
-0.017710514,
-0.008829421,
0.020617055,
0.011593863,
-0.0046504634,
0.0087389955,
-0.0019716027,
0.02960795,
0.003195579,
-0.018485593,
0.014222668,
-0.025086666,
-0.018834377,
0.01344759,
0.013460508,
-0.002013586,
0.006242601,
-0.01742632,
0.003510454,
-0.028186975,
-0.0064622066,
-0.015191514,
0.008448342,
-0.012549792,
-0.008558145,
-0.016470391,
0.0022671008,
-0.014054733,
0.0033812744,
0.0026562542,
-0.0031745872,
-0.023058547,
-0.00073914917,
-0.016806258,
0.018085135,
-0.015837412,
-0.013538016,
-0.0045664967,
-0.033741694,
-0.026843509,
-0.00033667416,
-0.01874395,
0.028057795,
0.019079817,
0.0008969904,
-0.03420674,
-0.012065369,
-0.050483365,
-0.015579052,
-0.007550544,
-0.002569058,
0.01508817,
0.01919608,
-0.0063039614,
-0.0051316572,
-0.006885269,
0.0068917284,
-0.044050224,
-0.025745481,
0.034129236,
-0.008022049,
0.027670257,
-0.012162253,
-0.0042919903,
0.005845374,
0.01836933,
-0.0012683816,
-0.005800161,
0.027127704,
-0.027876945,
0.0030034243,
0.0017536122,
0.028807037,
-0.0023397645,
0.017142124,
0.013835128,
-0.0257584,
0.0051219687,
0.00022626604,
-0.010398953,
0.006552632,
0.018963557,
-0.0009260558,
0.024350343,
0.018679362,
0.0071953004,
-0.022877697,
-0.0020103566,
-0.011438848,
0.012833987,
0.02114669,
0.010896294,
0.02013909,
0.00072461646,
0.012045992,
0.0013297419,
-0.007621593,
-0.039115563,
0.0052737547,
0.0000472565,
-0.025099585,
-0.0190669,
-0.009352598,
-0.008642111,
-0.03219154,
0.006949859,
0.013977226,
-0.023949886,
-0.016147442,
0.009830563,
0.0067754667,
-0.0022008964,
-0.006749631,
-0.0011706896,
-0.0027676716,
-0.019144408,
-0.014235585,
-0.0077249366,
-0.024750799,
-0.00883588,
-0.005771096,
0.0016389654,
0.02044912,
0.005296361,
-0.017839694,
-0.021185445,
-0.008280409,
0.1882921,
-0.008997355,
0.0036816169,
0.014687713,
0.010134134,
-0.012323728,
0.0055579497,
0.0038204847,
-0.0027822044,
0.013408836,
0.03655781,
-0.012452908,
0.0074278233,
0.0049088225,
0.038495503,
-0.009481778,
-0.0062652077,
0.0075699207,
-0.014636042,
0.00082109746,
0.034826804,
-0.028109467,
0.032165706,
0.018382248,
0.024505358,
-0.00884234,
-0.009514073,
-0.0032311033,
0.017788023,
0.0096109575,
-0.023936968,
0.027153539,
-0.009191124,
-0.015385283,
-0.016186196,
0.0041821874,
-0.013253821,
-0.016328294,
0.0030841616,
0.006281355,
0.0151398415,
-0.0076345108,
-0.0017003256,
-0.0102633145,
0.010599181,
0.0007964726,
0.020384531,
-0.0007298644,
-0.020927085,
-0.014338929,
-0.039218906,
0.0068658926,
0.018666442,
-0.0034038809,
-0.017723432,
-0.017529663,
0.023071466,
0.0049378877,
-0.0067883846,
0.02291645,
-0.009953284,
0.0026820903,
-0.015049417,
0.023601102,
-0.008971519,
0.030718895,
-0.00883588,
0.004963724,
0.013576769,
-0.031674825,
0.005467524,
-0.017245468,
-0.0030825466,
-0.00007866832,
0.007757231,
-0.02960795,
0.032372393,
0.011031932,
0.0029792031,
0.029917981,
0.010889835,
-0.006717336,
-0.019428603,
0.028781202,
-0.03730705,
-0.026714329,
0.014958991,
0.024531195,
0.00013775787,
-0.023601102,
-0.022373896,
-0.024221163,
-0.0070919567,
-0.015165678,
0.024892896,
0.0015881009,
0.00637501,
0.005422311,
0.0104377065,
0.0027240736,
-0.014971908,
0.056735653,
0.012427072,
0.010418329,
0.007053203,
0.006885269,
-0.009061945,
-0.004469612,
0.009572204,
-0.010398953,
0.03893471,
-0.03074473,
-0.0010592722,
-0.024892896,
-0.0011529274,
0.020940004,
0.003959353,
-0.027721928,
0.029272083,
0.0036945348,
-0.020436203,
-0.019493192,
0.013770538,
0.017904283,
-0.015772821,
0.014287257,
-0.03852134,
0.0061844704,
0.011083605,
-0.022709763,
0.01768468,
-0.015488626,
-0.0022880926,
0.040123165,
0.008887553,
-0.014778139,
0.008596898,
-0.009727219,
-0.0059196525,
0.0061005037,
0.01597951,
-0.0046956763,
-0.0058227675,
0.00011656435,
-0.01154865,
-0.011380717,
0.021753835,
0.022490157,
-0.017658843,
-0.011270915,
-0.029685458,
-0.037281215,
-0.0016454244,
-0.00038087778,
0.019945322,
-0.007770149,
-0.022115538,
0.009171748,
0.0020733315,
0.0036977644,
-0.017129207,
0.0048151673,
0.0053932457,
-0.008525849,
-0.0077184774,
-0.009255714,
-0.16100937,
-0.0031552103,
0.007020908,
-0.023756117,
0.024828307,
0.009049026,
0.00934614,
-0.012646677,
-0.009352598,
0.001644617,
0.037436232,
-0.0024834767,
-0.04017484,
-0.012420612,
0.0053932457,
-0.00023555082,
0.00020053105,
0.034180906,
-0.0029582113,
0.0026207299,
0.022205962,
-0.0031471364,
0.018847294,
0.011845764,
-0.012911495,
0.0042823018,
0.0028887775,
0.0045632673,
-0.011574486,
-0.032475736,
0.007938082,
-0.002152454,
0.03624778,
0.015540298,
0.012142876,
-0.006236142,
-0.017594254,
-0.005170411,
-0.012769397,
-0.003826944,
0.026972687,
0.009384894,
0.032139868,
-0.010786491,
-0.016612489,
0.00536741,
0.025073748,
0.001353963,
0.043843534,
-0.013253821,
0.017852612,
0.011283833,
0.015230267,
0.017762186,
0.013744703,
0.0117876325,
0.017852612,
0.0034878475,
0.0017003256,
-0.0062781256,
0.0046666106,
-0.016250785,
0.028936217,
-0.01123862,
-0.013538016,
-0.02449244,
-0.013370082,
0.03441343,
-0.024518276,
0.018524345,
-0.010928589,
0.011077145,
0.022826025,
-0.017762186,
0.014326011,
0.022838943,
-0.010618558,
0.011380717,
-0.0040045655,
-0.022554748,
-0.017142124,
0.012459367,
-0.029633787,
0.008984437,
0.003768813,
0.030718895,
0.022490157,
0.01975155,
0.010657312,
-0.006358863,
0.013072969,
-0.0371262,
0.0034490938,
-0.010398953,
0.035756897,
0.013938473,
-0.023342742,
-0.0039496645,
-0.015837412,
0.008887553,
0.03017634,
-0.028936217,
-0.009817645,
0.025667975,
0.007905788,
-0.002217044,
-0.005315738,
0.018265987,
0.04774476,
0.0028177288,
-0.02891038,
-0.009753055,
0.023148973,
0.0076345108,
-0.016044099,
0.013525098,
-0.018136807,
0.0151398415,
-0.0059584063,
-0.040226508,
0.05379036,
-0.008106016,
0.010269773,
0.002247724,
0.0025722876,
-0.03919307,
-0.11316127,
-0.028548678,
0.004324285,
0.0039238282,
-0.022231799,
0.020384531,
-0.0023962804,
0.04027818,
-0.022787271,
0.02663682,
-0.016845012,
-0.008661488,
0.0043824157,
-0.021508394,
-0.00820936,
-0.0004222556,
0.010586264,
-0.0021476098,
-0.025590466,
0.022838943,
-0.000867925,
0.011225702,
-0.007234054,
-0.014119323,
-0.001206214,
-0.0061457166,
-0.027980288,
0.010993179,
0.014545616,
0.018679362,
0.0034426346,
-0.009378434,
0.0044114813,
0.0028952365,
-0.010172889,
0.010760656,
-0.0050153956,
-0.025551712,
0.03976146,
-0.0200745,
-0.006103733,
0.01768468,
0.009145911,
-0.0030082685,
-0.009107158,
0.01016643,
-0.024208246,
-0.010482919,
0.033431664,
-0.020927085,
-0.010386035,
0.0016680307,
-0.03162315,
-0.0012514268,
0.009443024,
-0.0029969653,
-0.0056322278,
0.0009833792,
0.00005737388,
-0.0024899356,
-0.017955955,
-0.0054513765,
-0.0044534644,
0.022993958,
0.02298104,
-0.0061327987,
-0.006161864,
-0.015230267,
0.019273587,
-0.007595757,
-0.0071436283,
0.012394777,
-0.01938985,
-0.00079001364,
0.0103731165,
-0.0052188532,
-0.0011674601,
-0.013860964,
-0.004853921,
-0.012762939,
-0.0041724993,
-0.015346529,
0.016199114,
-0.021353377,
0.024040312,
0.0014669951,
0.014145159,
-0.0063814693,
-0.014326011,
-0.011658453,
-0.008932765,
0.05379036,
0.017516745,
-0.000086035594,
0.005942259,
0.016069934,
-0.0047893315,
0.0018004398,
0.0165479,
0.026610985,
-0.010689607,
-0.014739385,
-0.05632228,
-0.000014507467,
-0.0013886801,
-0.008596898,
0.020617055,
0.014661877,
0.0031099974,
-0.021185445,
-0.010631476,
0.02903956,
-0.011012556,
0.018705197,
-0.040794898,
0.0039561233,
-0.02462162,
-0.0025028535,
0.021805506,
-0.008448342,
0.031493973,
0.04464445,
-0.0023494528,
-0.019803224,
0.011322587,
-0.0021992817,
-0.024699127,
0.0035362898,
-0.045187004,
0.018976474,
-0.013912636,
-0.009475319,
0.024544112,
-0.041363288,
-0.0056419163,
0.0035007654,
-0.0065203374,
-0.013279657,
-0.00062006176,
0.04490281,
0.011341964,
0.030021325,
-0.014545616,
-0.031183941,
0.015114006,
0.015708232,
-0.009094239,
-0.011057769,
-0.029375426,
-0.01073482,
0.005215624,
-0.018731033,
0.03363835,
0.0059939306,
0.016082853,
-0.028626185,
0.006213536,
-0.0026401067,
0.025448369,
-0.00605852,
0.012033074,
-0.030667223,
-0.00061804336,
0.019364012,
0.0011464685,
-0.00096884655,
-0.008454801,
0.0023752889,
-0.01786553,
-0.027825272,
-0.015798658,
-0.026003841,
-0.021702163,
-0.0029646703,
-0.0029436788,
0.01464896,
0.014687713,
-0.0029049248,
-0.014158078,
0.009837022,
-0.016845012,
0.009359058,
0.022671008,
0.016341211,
-0.0047699544,
0.021818424,
0.030150505,
-0.018343495,
-0.0053641805,
0.0059810127,
-0.0051542637,
-0.0008138311,
-0.012917954,
0.014558534,
0.00056556414,
-0.01975155,
0.019157326,
-0.008183524,
0.015320693,
-0.010547509,
0.010340822,
0.03485264,
-0.0033715859,
0.010179347,
-0.0071242517,
0.0021088559,
-0.027256882,
0.0344651,
-0.029530443,
-0.014920237,
-0.02872953,
0.006213536,
0.03017634,
-0.004330744,
0.01944152,
-0.009798268,
-0.02398864,
-0.02090125,
-0.015902001,
0.013964308,
-0.019467356,
0.04172499,
-0.001401598,
0.003939976,
0.009585122,
0.0015945599,
0.0165479,
-0.0016341212,
0.020784987,
-0.010095381,
0.028703693,
-0.019996993,
0.008338539,
-0.022826025,
-0.01710337,
-0.006213536,
-0.014558534,
-0.021095019,
0.013137559,
0.03782377,
-0.028755365,
0.084483415,
0.013964308,
-0.026946852,
-0.003959353,
-0.023329824,
0.027747765,
-0.00019084258,
-0.0073696924,
0.0041821874,
-0.029659621,
-0.02070748,
-0.032863274,
0.0035879617,
-0.033121634,
-0.0052511482,
0.0000851273,
-0.00054093933,
0.015617806,
-0.008228737,
-0.029814638,
0.009669089,
-0.0099145295,
0.0077055595,
0.034258414,
-0.015540298,
-0.0083256215,
0.012950249,
-0.003655781,
-0.019092735,
-0.038598847,
-0.0038043375,
-0.014842729,
-0.042965114,
-0.011600322,
-0.0005877669,
-0.003352209,
0.0023914361,
-0.025797153,
0.025422534,
0.015798658,
-0.007337398,
0.0031988083,
-0.018227233,
-0.012924413,
-0.0012263983,
-0.01585033,
-0.021534229,
-0.018911885,
0.026107185
] |
Abiotic and biotic stressors in human cells are often a result of sudden and/or frequent changes in environmental factors. The molecular response to stress involves elaborate modulation of gene expression and is of homeostatic, ecological, and evolutionary importance. Although attention has primarily focused on signaling pathways and protein networks, long non-coding RNAs (ncRNAs) are increasingly involved in the molecular mechanisms associated with responses to cellular stresses. We identified six novel short-lived long ncRNAs (MIR22HG, GABPB-AS1, LINC00152, IDI2-AS1, SNHG15, and FLJ336 | [
-0.03284538,
-0.00442252,
0.0162626,
-0.014501596,
-0.0069973203,
0.012233637,
-0.007771095,
0.023800228,
-0.020638427,
-0.0031718072,
-0.0018777365,
-0.011179703,
-0.014194755,
0.015608894,
0.011900114,
0.0007320838,
0.03594048,
0.008758324,
0.007324173,
0.0113197835,
-0.01582235,
0.014301483,
0.000948874,
-0.015849032,
0.0019661202,
0.010332554,
0.010172463,
-0.047306955,
-0.003992275,
-0.034339566,
0.004099002,
0.0046359748,
-0.022105929,
-0.010866191,
-0.01811699,
-0.0061968644,
0.000465682,
-0.022065906,
0.013280901,
-0.02026488,
0.02553455,
0.024574002,
-0.0054631126,
0.0008317239,
-0.0191309,
-0.004152366,
0.00727748,
-0.01814367,
-0.0007516783,
0.01882406,
0.026748575,
0.013134151,
-0.029830331,
-0.0039889393,
-0.01598244,
-0.002476411,
0.013280901,
0.015648916,
0.013007412,
-0.0031234464,
-0.012567161,
0.0043491446,
-0.024440592,
0.019811288,
-0.009458723,
0.017049715,
0.022919726,
0.006520382,
-0.011086317,
-0.0028499572,
0.009932326,
0.019090878,
-0.0067038196,
0.026281642,
0.017636716,
0.007104048,
-0.018503876,
0.0009888968,
0.011966819,
0.004809407,
0.0043324684,
-0.0060968073,
0.0062302165,
0.006363626,
0.0121869445,
-0.018570581,
-0.013901254,
-0.005052879,
0.0019444412,
-0.012540479,
0.0073308437,
0.02624162,
0.0039755986,
0.010706101,
-0.01783683,
-0.0072708097,
-0.0043558152,
0.012960718,
-0.010232497,
-0.03225838,
-0.025281072,
0.0058600055,
-0.0021128706,
-0.011466534,
-0.02154561,
-0.0060100914,
0.016155872,
-0.00012892763,
0.013034093,
-0.003725456,
-0.03471311,
0.0064136544,
-0.026855301,
-0.016396008,
0.030710831,
0.0061234892,
0.034446295,
-0.0015467147,
-0.0076510264,
-0.017596694,
-0.0020645098,
0.016022462,
0.008017902,
-0.02684196,
0.02584139,
0.010886203,
-0.0102591785,
-0.00491947,
-0.010205816,
0.008691619,
-0.00855821,
-0.0028199402,
-0.006053449,
0.007637685,
-0.03271197,
0.0055331527,
-0.011326454,
-0.022786317,
-0.011906784,
-0.014034663,
0.0020344926,
0.026775256,
-0.046533182,
0.0066838083,
0.008871722,
0.004726026,
0.011866761,
0.012066876,
0.01782349,
0.0056165336,
0.01198683,
-0.0115665905,
0.010659407,
-0.016009122,
-0.016662827,
0.026855301,
-0.012480444,
-0.0042190705,
-0.022359407,
-0.027935918,
0.025921436,
0.012607183,
0.02197252,
0.02412041,
0.020171493,
0.02253284,
0.010352566,
-0.0049895095,
0.0062568984,
-0.0062568984,
-0.0031884834,
0.0027365594,
-0.025521208,
0.011546579,
-0.0025998147,
0.021865793,
-0.0023496721,
0.022212656,
-0.012540479,
-0.021572292,
-0.013741163,
0.007831128,
0.022039225,
-0.007817788,
-0.0057766247,
-0.0018994156,
0.0345797,
-0.0025147663,
0.007464253,
-0.024293842,
-0.013794526,
0.0063836374,
0.010552679,
0.0043424745,
-0.63780344,
-0.014461573,
0.009872292,
0.0046593216,
0.009238597,
0.016476054,
0.013567731,
0.00029141604,
-0.007003991,
0.039862715,
-0.015395439,
0.0069572977,
0.011226397,
-0.031698063,
-0.022719612,
-0.043891676,
-0.015515507,
0.0007058188,
0.03351243,
0.009512086,
-0.01982463,
0.0035920467,
0.007217446,
0.0165561,
0.014675029,
0.016662827,
0.020785177,
-0.026321664,
-0.0036921038,
0.03722121,
-0.008051254,
0.020064766,
0.0030150514,
-0.005739937,
0.0534171,
0.0036787628,
-0.013454333,
0.039702624,
0.029803649,
0.013287571,
-0.029270012,
-0.0016609464,
0.002232939,
0.007931186,
-0.029430103,
0.026868643,
0.0058333236,
-0.005306357,
0.0029583522,
0.0049561574,
0.017890194,
0.027802508,
-0.026174914,
0.004922805,
0.012894014,
0.001584236,
0.021412201,
-0.02684196,
0.018904105,
0.0069906497,
-0.0057466077,
0.017556671,
-0.024560662,
-0.026228279,
-0.00671049,
0.011052964,
-0.021038655,
0.0077844355,
0.0043458096,
0.010479304,
0.019237628,
0.03668757,
0.012567161,
-0.00181937,
0.012673888,
0.03297879,
0.012206956,
0.014568301,
-0.003595382,
0.02384025,
0.010679418,
-0.0041423603,
-0.023520067,
0.0042457525,
0.023279931,
-0.0045025656,
-0.013080787,
0.024867503,
0.007677708,
-0.0119935,
-0.007764424,
-0.009732212,
-0.019050855,
-0.025721323,
-0.0063135973,
0.021372179,
-0.0010164125,
0.018076967,
0.02868301,
-0.026308324,
-0.013380958,
-0.0056865737,
0.014461573,
0.0033369013,
-0.0015083594,
-0.002302979,
-0.020571722,
0.011519898,
0.030657468,
-0.0063569555,
0.009652167,
-0.002433053,
-0.026201596,
-0.0041423603,
-0.019411061,
-0.017570011,
0.019037515,
0.018383808,
0.0034586373,
-0.036447436,
0.010299202,
0.0051129134,
-0.0003856364,
-0.023106499,
0.010852851,
0.009345325,
-0.01628928,
-0.006977309,
-0.009078506,
0.0064169895,
0.008124629,
-0.005476454,
0.032631926,
-0.017663397,
0.0067872005,
0.011333124,
0.025161004,
0.014208096,
0.011293101,
-0.050135233,
-0.019704562,
0.0013449329,
-0.008865051,
-0.026094869,
-0.019197606,
-0.012040194,
-0.0097055305,
0.007864481,
0.022919726,
0.009465394,
0.0102591785,
-0.0063836374,
-0.0052263113,
0.007464253,
0.015302053,
0.000015829331,
-0.007824458,
-0.024040366,
-0.008644925,
-0.014074686,
0.008177993,
0.000535305,
-0.022999771,
0.0129874,
-0.024907526,
-0.00058575044,
-0.009832269,
0.02282634,
0.022332724,
-0.03167138,
0.015355416,
-0.035059977,
-0.02213261,
0.017663397,
-0.012753934,
0.003595382,
-0.020344926,
0.020184834,
-0.011239737,
-0.011052964,
-0.011206386,
-0.026788598,
-0.017223148,
-0.019210946,
0.014301483,
0.03167138,
0.048561003,
0.0078444695,
0.022479475,
0.03324561,
-0.00095721206,
0.010626054,
-0.03794162,
0.014101368,
0.006863911,
-0.029136602,
0.0000384073,
-0.018810717,
0.0069439565,
0.0066171037,
0.020038085,
-0.02484082,
0.0010347563,
-0.009378677,
0.0014524943,
-0.016235918,
0.00020126051,
-0.017516648,
0.0102658495,
-0.015849032,
0.01696967,
0.020891905,
-0.016102508,
-0.027962599,
-0.008764994,
0.01384789,
-0.0059834095,
0.007911175,
-0.0045559295,
0.0012298675,
0.013561061,
-0.008391448,
0.0016642816,
-0.004936146,
-0.009118529,
0.027002051,
-0.018463854,
0.017489966,
-0.00037979975,
0.01027252,
0.011773375,
0.006523717,
0.0075242873,
-0.012994071,
0.012460433,
-0.00039251533,
-0.0126805585,
-0.0113798175,
0.03908894,
0.0039755986,
-0.013187514,
-0.0044191848,
0.009065165,
-0.0070173317,
0.025174344,
0.0121869445,
0.035300113,
0.014514937,
-0.014301483,
0.0045559295,
-0.012460433,
0.022492817,
-0.029270012,
-0.006747178,
0.016716192,
-0.024867503,
0.0036687572,
0.0057432726,
0.053710602,
0.014461573,
0.007377537,
0.009598803,
0.012713911,
-0.008258039,
0.0045059007,
0.0026248288,
0.000023229382,
0.0036687572,
-0.0256813,
0.0026581814,
-0.010906214,
-0.011386488,
0.0036654219,
-0.013427651,
0.025908096,
0.0059567275,
0.020558381,
0.0066971495,
0.023626795,
-0.01226699,
0.0025281073,
0.013114139,
0.031457923,
0.018717332,
-0.011199715,
-0.027909236,
-0.040689852,
0.014528278,
-0.0076576965,
-0.004892788,
-0.0021528935,
0.003998945,
0.0066137686,
-0.0032018244,
-0.0059267106,
0.00449256,
0.009251938,
-0.024293842,
0.019157583,
-0.0050862315,
0.022946408,
-0.00028495403,
-0.0043224627,
-0.0036854332,
0.019477764,
0.00955878,
0.0010355901,
0.0042891107,
-0.019771265,
-0.028416192,
0.000049950337,
-0.009492075,
0.008598233,
-0.028736373,
0.009858951,
0.026148232,
0.0010722777,
-0.000444003,
0.013334264,
-0.005252993,
0.003360248,
-0.026975371,
-0.025080958,
-0.008384777,
0.040823262,
0.019744584,
-0.008905074,
0.03153797,
-0.009492075,
0.007244128,
-0.023573432,
-0.011306442,
0.015262029,
-0.03596716,
-0.013027423,
0.00075001066,
0.0015008552,
0.021465564,
0.018503876,
0.015902394,
0.014501596,
-0.027589053,
-0.028336145,
0.0002716131,
0.020931927,
-0.0105126565,
0.027962599,
0.0516561,
0.0056732325,
-0.0009797249,
-0.025107639,
0.019624515,
0.0051596067,
-0.0073575256,
0.013967959,
0.039702624,
-0.0038121722,
0.029056557,
0.003198489,
0.01027252,
0.024293842,
0.00549313,
0.013307583,
-0.0067238314,
0.022559522,
-0.0030333952,
0.025627935,
-0.013280901,
-0.011973489,
-0.012507127,
0.0007233288,
0.027042074,
-0.007791106,
-0.0015308723,
0.018597264,
-0.02924333,
0.0041190134,
-0.022279361,
0.019784607,
-0.0024397236,
0.0006507875,
-0.008498175,
-0.003103435,
-0.027188824,
-0.012540479,
-0.009745553,
0.0025481186,
-0.015915735,
0.006023432,
-0.0077844355,
-0.009098518,
0.0034786488,
-0.008484835,
-0.0059133694,
-0.0026665193,
-0.04397172,
-0.029430103,
0.014248119,
0.01084618,
0.009972349,
0.014488256,
-0.013254219,
0.0019911346,
0.029776966,
-0.025454504,
-0.024734093,
0.0047126855,
-0.026001481,
0.023173204,
-0.0091452105,
-0.0024480615,
-0.006797206,
-0.010492645,
-0.009932326,
-0.020785177,
-0.009045154,
-0.0018960803,
-0.0045359177,
-0.0100190425,
0.02385359,
0.02167902,
0.02554789,
-0.00018718999,
-0.010245838,
0.0016184222,
-0.03538016,
-0.03452634,
-0.02197252,
-0.01384789,
-0.034659747,
0.00056115305,
0.01798358,
-0.0055098063,
0.0054897945,
0.029590193,
-0.019104218,
-0.00091635546,
0.022079248,
-0.0011181372,
0.02425382,
-0.0039755986,
0.008011231,
-0.01696967,
0.0010372577,
0.004392503,
-0.023026453,
0.020758495,
0.0043724915,
-0.0031701396,
0.020918585,
-0.003090094,
-0.009425371,
-0.026508437,
-0.0046426454,
-0.024747435,
0.03393934,
0.015915735,
-0.033005472,
-0.019757925,
-0.0004544256,
-0.00420573,
0.025908096,
-0.008811687,
-0.011546579,
-0.039035577,
-0.0039022234,
-0.0039522517,
-0.0012281998,
0.023786888,
-0.030817559,
-0.02670855,
0.022612885,
0.0052029644,
0.012193615,
-0.03108438,
-0.000049559487,
-0.02438723,
-0.002646508,
-0.021492247,
-0.048134092,
0.00014654183,
-0.012573831,
0.027175484,
0.003962258,
0.046613228,
-0.020771835,
0.007617674,
0.02740228,
0.019704562,
0.00048069056,
0.00020032248,
-0.0053797318,
-0.0188374,
0.008798347,
0.03196488,
0.008604903,
0.0007812785,
-0.010485975,
-0.013187514,
0.019918015,
-0.008077936,
-0.030924287,
-0.00027390607,
-0.030924287,
-0.02654846,
0.019611174,
-0.033032157,
0.00870496,
-0.012020183,
-0.009545439,
0.007237457,
0.0064103194,
0.017516648,
-0.029003192,
0.018917445,
-0.02782919,
0.025788028,
-0.023586772,
0.012347035,
-0.026161574,
-0.0068372292,
-0.013594412,
-0.0034219497,
0.0031934862,
-0.017650057,
0.01813033,
0.017663397,
-0.009645496,
-0.006233552,
-0.016049145,
-0.03580707,
-0.007264139,
0.0039589223,
-0.0017359891,
-0.0009630487,
0.0013140821,
-0.040182896,
-0.041863855,
0.0075242873,
0.011746693,
-0.0030233893,
0.022732953,
-0.017730102,
-0.01898415,
0.026908666,
-0.006296921,
0.005313027,
-0.0123737175,
0.038501937,
-0.002524772,
-0.010232497,
-0.014928506,
-0.014301483,
0.014688369,
-0.0013549387,
0.03284538,
0.008538199,
-0.018744014,
-0.0064336658,
0.018877422,
0.016315963,
-0.016849602,
-0.01967788,
0.029136602,
0.009725542,
-0.003290208,
-0.015862372,
-0.017543329,
-0.015955757,
0.0121869445,
-0.016582781,
0.0045125713,
0.011359806,
-0.0103258835,
0.010932896,
0.004255758,
-0.001967788,
0.003992275,
0.00085465366,
-0.015048575,
-0.006393643,
-0.00046860034,
0.016929647,
-0.010452623,
-0.0043157926,
0.025561232,
0.008458152,
-0.0034219497,
0.00799122,
0.013254219,
0.013074116,
-0.0031701396,
0.01083951,
0.041143443,
-0.02996374,
-0.020745154,
0.02139886,
0.007831128,
0.015088597,
-0.005022862,
-0.0013466006,
-0.01241374,
-0.022012543,
0.0071307295,
0.006530388,
0.014007982,
0.0014074686,
-0.027509008,
-0.020625085,
-0.011406499,
-0.023413341,
-0.011359806,
-0.000513626,
-0.030417332,
-0.0066304444,
0.006950627,
0.007917845,
0.03751471,
0.013174173,
0.0024513968,
-0.020531699,
0.028096009,
-0.019464424,
0.019797947,
-0.014314823,
-0.012073546,
-0.020505017,
0.030844241,
-0.0034019384,
-0.025988141,
-0.00040439708,
-0.019757925,
-0.029483465,
0.0021078677,
-0.0078111175,
0.027348917,
0.018450513,
-0.0067438427,
0.030310605,
0.009605473,
0.0021628991,
-0.008698289,
-0.0058566704,
0.015075256,
-0.010452623,
0.007857811,
0.017756784,
-0.013607753,
0.0057732896,
-0.018383808,
-0.008471494,
0.00084172963,
0.0033218928,
-0.013741163,
-0.007837799,
0.0018277081,
0.00047652153,
-0.004706015,
-0.0149151655,
-0.010892874,
-0.021799088,
0.024600685,
-0.0022079246,
0.0050628847,
-0.014301483,
0.0007992054,
0.044905588,
-0.0090251425,
0.002119541,
0.017743444,
-0.01198683,
-0.007917845,
-0.032765336,
0.0046359748,
-0.005266334,
0.03628734,
-0.0036887685,
0.0013390963,
-0.029510148,
0.012887343,
-0.034793157,
-0.04023626,
0.012340365,
0.0012315351,
0.0050128563,
0.01783683,
0.0017676739,
0.0037854903,
-0.011820069,
0.0064003137,
0.0059834095,
-0.0070973774,
0.007604333,
0.009291961,
0.028469555,
0.017636716,
-0.01769008,
0.0018427166,
0.033032157,
-0.020184834,
-0.021665677,
0.025494527,
-0.0066971495,
0.022079248,
-0.018103648,
0.0051129134,
-0.007791106,
0.0059834095,
0.02297309,
-0.015115279,
-0.016355986,
0.023319954,
-0.0027832526,
-0.016462713,
0.014928506,
0.0071974345,
0.028362827,
0.024173774,
0.00067621865,
-0.036714252,
0.020171493,
-0.024413912,
0.014715051,
0.019651197,
0.00899846,
0.019557811,
0.0056131985,
-0.023293272,
-0.025494527,
-0.029163284,
-0.00899846,
0.006977309,
0.025374457,
0.0059133694,
-0.020918585,
0.0028699685,
-0.010052394,
-0.024360547,
-0.002019484,
-0.022172634,
-0.0042023943,
-0.006250228,
-0.010739452,
-0.003381927,
0.004655986,
-0.01226699,
-0.004655986,
-0.036180615,
-0.016209235,
-0.0005553164,
-0.023186544,
-0.020158153,
0.01999806,
0.014194755,
0.012660547,
-0.005593187,
-0.00827805,
0.00056740665,
-0.013020752,
0.022025883,
0.18346454,
-0.024333864,
-0.00856488,
0.008684949,
0.016436031,
-0.010112429,
0.007751083,
-0.009372007,
-0.00549313,
0.019157583,
0.020798517,
0.008671608,
0.0074108895,
0.00053822336,
0.013754504,
-0.026134891,
-0.019451084,
0.014861802,
-0.010232497,
0.011313112,
-0.0028299459,
-0.019357696,
-0.00022220994,
-0.019717902,
0.055605017,
0.008885062,
-0.03580707,
-0.014661687,
0.011973489,
-0.0006991484,
-0.0056865737,
-0.001740992,
0.0014675028,
0.023066476,
0.016049145,
0.016769554,
0.009258609,
0.0016642816,
-0.00671049,
-0.012206956,
-0.0044291904,
0.017556671,
0.010399259,
-0.0035019955,
0.03111106,
0.00055198115,
-0.018797377,
-0.02540114,
-0.00856488,
-0.0032568558,
-0.037167843,
0.032044925,
-0.01783683,
0.03551357,
0.014474914,
0.0032835377,
-0.0006445339,
0.008084606,
0.002933338,
0.020344926,
-0.021652337,
-0.0042757695,
-0.024160434,
0.0021262115,
-0.034926567,
0.027855871,
-0.027375598,
0.004048974,
0.0009422035,
-0.009378677,
-0.030710831,
-0.012914025,
-0.016169213,
0.0078111175,
-0.011906784,
-0.0002616074,
0.02469407,
-0.0023063142,
0.015328734,
0.023773545,
0.008438141,
-0.0008896736,
-0.05291015,
-0.0032985462,
0.007077366,
-0.037914935,
0.025454504,
0.00957212,
-0.050135233,
0.008071265,
0.017196465,
0.0036987741,
-0.01640935,
-0.016035805,
0.008304732,
-0.00025660454,
-0.021772405,
-0.0037588084,
-0.027909236,
-0.016662827,
-0.04007617,
0.09808255,
-0.004706015,
0.012547149,
-0.014968529,
0.011766705,
0.0019144241,
0.007490935,
0.0018427166,
0.015475485,
0.0046626567,
-0.013440992,
0.014568301,
-0.013561061,
-0.016809577,
0.0024630702,
0.033138882,
-0.03207161,
0.059980843,
-0.018437171,
-0.013394299,
-0.0020094784,
-0.008198004,
0.011913455,
0.00841813,
0.0099523375,
-0.0002276297,
-0.014101368,
0.003782155,
-0.024747435,
0.010279191,
0.008764994,
-0.0027999287,
0.0036587515,
0.0054130843,
-0.0061168186,
0.034339566,
-0.026668528,
-0.019504447,
0.0011406499,
-0.010886203,
-0.016862942,
0.0056732325,
0.018904105,
-0.0018610604,
0.0049861744,
0.0328187,
0.024067046,
-0.01642269,
-0.008104618,
-0.010212486,
-0.0103859175,
-0.009692189,
-0.008064595,
0.010926225,
-0.01782349,
-0.020464994,
-0.01127309,
0.0035086658,
0.005806642,
-0.03668757,
0.0049294755,
0.012653877,
-0.0057699545,
0.008438141,
0.008384777,
-0.1677756,
0.029216647,
0.011679988,
-0.015715621,
0.012960718,
0.006963968,
-0.00870496,
0.0060934722,
-0.011533238,
0.0031968215,
0.014448232,
-0.004412514,
-0.018730672,
-0.041036714,
-0.0025864737,
0.0021779076,
0.008671608,
0.030283922,
0.011459863,
0.008738312,
-0.006607098,
-0.013394299,
0.016382668,
-0.013501026,
-0.00005096654,
0.005396408,
-0.00634695,
-0.019344356,
-0.013347605,
-0.013300912,
-0.025988141,
0.004766049,
0.014821779,
0.000035801648,
0.034793157,
0.023146521,
-0.010779476,
-0.022332724,
-0.012140251,
0.008831698,
0.03353911,
0.026881984,
-0.009231927,
0.01455496,
-0.027562372,
0.006577081,
0.017650057,
0.0037988313,
-0.009638825,
-0.0077577536,
0.011359806,
-0.003595382,
0.009965679,
0.0044858893,
0.02582805,
0.020344926,
-0.00086549314,
0.018437171,
-0.000110688066,
-0.020638427,
-0.013927936,
-0.009218586,
0.037461344,
0.011633296,
0.006003421,
-0.0032568558,
0.006593757,
-0.0012173603,
-0.02085188,
0.018744014,
-0.009298632,
-0.024067046,
0.010105758,
-0.011639966,
0.008758324,
0.0024247149,
-0.011893444,
0.010099088,
-0.024067046,
0.007537628,
-0.011046294,
0.010332554,
-0.023573432,
-0.026975371,
0.0044592074,
-0.00020542955,
0.014421551,
0.020878563,
0.0050128563,
0.0077844355,
0.027082099,
-0.008258039,
0.009732212,
-0.010219156,
0.017396579,
-0.008478164,
0.02297309,
-0.0012382055,
-0.005713255,
0.00072624715,
0.019157583,
-0.009278621,
0.0030750856,
0.01284065,
0.015795667,
-0.016862942,
-0.017369898,
-0.024187114,
0.040609807,
-0.017796807,
-0.01926431,
0.011793386,
0.0053597204,
0.032925427,
0.0063436143,
0.026174914,
-0.0015417117,
-0.010232497,
-0.0017459949,
-0.034926567,
0.07689715,
0.019317674,
-0.016182555,
0.0024097064,
-0.0024580671,
-0.023520067,
-0.14429556,
-0.024960889,
0.018303763,
0.01640935,
-0.009912315,
0.02382691,
-0.009632155,
0.044185176,
-0.014594982,
0.038822122,
-0.025227709,
0.0059900796,
-0.009372007,
-0.0074976054,
0.00898512,
-0.010232497,
-0.004025627,
-0.014955188,
-0.0065137115,
0.029776966,
0.0010831171,
-0.021705702,
-0.006250228,
-0.010119099,
0.03111106,
0.0059600626,
-0.025161004,
0.011526568,
0.012347035,
-0.0035286774,
-0.017850172,
-0.00671049,
0.022572862,
-0.016462713,
-0.007003991,
0.00442252,
-0.00056990806,
-0.030283922,
0.031751424,
0.01814367,
0.009158552,
0.005839994,
0.019918015,
-0.017890194,
0.0056899088,
-0.011233067,
-0.0035420181,
0.021438882,
0.003290208,
-0.01614253,
-0.03794162,
-0.031164424,
-0.03852862,
-0.008124629,
0.029590193,
-0.016956327,
0.025174344,
0.042610947,
-0.014768415,
-0.009432041,
0.010145781,
0.001580067,
-0.014488256,
0.0084648235,
0.014541619,
-0.02485416,
-0.042771038,
-0.033619154,
0.023906955,
-0.011233067,
-0.0011740023,
0.025147662,
-0.0073375143,
0.006103478,
-0.025347777,
0.028789738,
-0.025334435,
-0.028096009,
0.0072107753,
-0.007250798,
-0.0034719782,
-0.022599544,
0.01827708,
-0.048320867,
0.022946408,
-0.014408209,
-0.004525912,
-0.0022929732,
-0.013247549,
-0.015462143,
-0.01969122,
0.024947548,
-0.00478606,
-0.007871152,
0.009278621,
-0.0029883694,
-0.008498175,
-0.003582041,
0.016676169,
-0.0028933152,
-0.017570011,
0.007911175,
-0.03908894,
0.019157583,
-0.0028916476,
0.0038021666,
0.0020611745,
-0.031884834,
0.014608324,
-0.018157013,
-0.012753934,
0.008424801,
-0.015795667,
0.005469783,
0.014394869,
-0.008664937,
-0.012660547,
-0.006133495,
0.022346066,
-0.0136744585,
0.026521778,
0.0259748,
-0.00082588725,
-0.0071774228,
0.025748005,
-0.0029099914,
-0.0009213583,
-0.030444013,
-0.012940707,
0.007057355,
-0.034472976,
-0.023013113,
0.019317674,
-0.02425382,
-0.01898415,
0.003612058,
-0.030764196,
-0.035033297,
0.025134321,
0.03628734,
0.009785576,
0.03594048,
-0.030710831,
-0.037568074,
-0.009365336,
-0.009672178,
0.0020711801,
0.007190764,
-0.04677332,
-0.0010139111,
0.0062735747,
-0.02525439,
0.04850764,
0.027589053,
-0.0085915625,
-0.010365906,
-0.014408209,
0.008671608,
-0.0071374,
-0.011126339,
0.0031051026,
-0.009385347,
0.0038655358,
0.030790878,
0.007504276,
0.016862942,
-0.00042232397,
0.0059033637,
-0.026054846,
-0.0003760476,
0.01997138,
-0.025201026,
-0.026308324,
0.002084521,
0.011353136,
-0.025507867,
0.019491106,
-0.00076460233,
-0.009645496,
0.0045359177,
-0.026375027,
0.014208096,
0.024067046,
0.0171431,
-0.00014737564,
0.014368187,
0.013354275,
0.010172463,
-0.009885632,
0.02298643,
0.027589053,
-0.019531129,
-0.008198004,
0.0074709235,
0.018570581,
0.015035233,
0.031431243,
0.009938996,
-0.041410264,
0.015849032,
0.008811687,
0.016342646,
0.001209856,
0.00090718357,
0.015955757,
-0.03564698,
0.0035653648,
0.023933638,
-0.02297309,
-0.016796237,
0.00090634974,
0.0014650014,
-0.015395439,
0.0030467361,
-0.0071840934,
0.0039789337,
-0.025467845,
0.02470741,
-0.0076510264,
0.017570011,
-0.0069706384,
0.037114482,
0.0141680725,
0.0015892389,
-0.0053830673,
-0.0041890536,
0.012547149,
0.022933068,
0.013140821,
-0.010779476,
0.027175484,
0.0060701254,
0.02769578,
-0.007030673,
-0.040503077,
-0.002646508,
0.008284721,
-0.004082326,
-0.0022296037,
0.013100798,
-0.010786146,
0.077644244,
0.02940342,
-0.0031267817,
0.017009692,
-0.025921436,
0.04949487,
-0.007350855,
0.023186544,
-0.0025431158,
-0.022466134,
0.015195325,
-0.022492817,
0.014781755,
-0.049921777,
-0.010305872,
0.03297879,
-0.018770695,
0.026922006,
-0.000017731458,
-0.010232497,
0.012220296,
-0.003451967,
0.017463284,
0.0069306158,
-0.028816419,
-0.0015283709,
0.03124447,
-0.016956327,
-0.0044758837,
-0.017356556,
0.007604333,
0.0013516034,
-0.04119681,
0.0050895666,
0.011026283,
-0.009205245,
-0.01799692,
-0.015809007,
0.012133581,
0.0073641962,
-0.00026494262,
-0.0024830815,
-0.028442873,
-0.018597264,
0.00727748,
-0.011740022,
-0.022719612,
-0.010165792,
-0.029937059
] |
We have identified and characterized the gene for a novel zinc finger transcription factor which we have termed lung Krüppel-like factor (LKLF). LKLF was isolated through the use of the zinc finger domain of erythroid Krüppel-like factor (ELKF) as a hybridization probe and is closely related to this erythroid cell-specific gene. LKLF is expressed in a limited number of tissues, with the predominant expression seen in the lungs and spleen. The gene is developmentally controlled, with expression noted in the 7-day embryo followed by a down-regulation at 11 days and subsequent reactivation | [
-0.026688574,
0.004490993,
0.0015913162,
-0.037775815,
-0.023415199,
0.02176531,
-0.04548409,
-0.0014378766,
-0.033525705,
-0.002646419,
0.00079112087,
-0.011186235,
0.016485672,
0.010902454,
-0.010585676,
-0.0005399256,
0.010777063,
-0.01738321,
-0.0006488181,
0.0031644835,
-0.015244957,
0.011951783,
-0.008968786,
-0.040600423,
-0.014954577,
0.0016474123,
0.019930637,
-0.029909154,
-0.016274488,
-0.01564093,
0.005071753,
0.012902117,
-0.009582545,
0.000979208,
-0.02688656,
-0.0038211385,
-0.005642614,
-0.027058149,
0.024378732,
-0.012948315,
0.040046062,
0.028008483,
-0.006477457,
-0.007734671,
-0.0049727596,
-0.017356813,
0.00892259,
-0.010460285,
-0.016300885,
0.03542638,
-0.0059461934,
0.0025226774,
0.0033690697,
-0.015258157,
-0.013185898,
-0.015218559,
0.025078285,
0.010955251,
-0.0067018415,
-0.021158153,
-0.028246067,
-0.010117108,
-0.014360618,
0.00789306,
-0.00409502,
0.021026162,
-0.015984107,
0.012783325,
-0.001417253,
0.019455468,
0.029170005,
0.016182093,
-0.008751001,
0.020379405,
0.024959493,
-0.004415098,
-0.0062794704,
0.015574935,
-0.011470015,
-0.0050684535,
0.0075234855,
0.00920637,
-0.021369338,
0.025751438,
0.023560388,
-0.019481868,
0.01185279,
0.018808713,
-0.006916327,
0.007266103,
0.0007329624,
0.023797972,
0.04561608,
0.025408262,
-0.021263745,
-0.022623252,
0.024893498,
0.00045949357,
0.002661268,
-0.060927033,
-0.018320346,
0.0040818206,
0.0020887572,
0.00007187321,
-0.041893933,
-0.006256372,
0.00978713,
0.00025263897,
0.014835785,
-0.006823933,
-0.030516313,
0.037934206,
0.0126711335,
-0.013067106,
0.048018314,
-0.03917492,
0.0033261725,
-0.0070087207,
-0.036587898,
0.00351096,
0.0114964135,
0.030833092,
-0.0006368564,
-0.038646955,
0.028721236,
0.007134112,
-0.0035769553,
-0.02573824,
-0.011918785,
0.0005555995,
0.019191487,
-0.0026530186,
0.005005758,
0.010684669,
-0.026662176,
-0.000024890094,
-0.011298427,
-0.004705478,
-0.008882992,
-0.0219237,
0.017224822,
0.028747633,
-0.021131754,
-0.004514091,
0.009556146,
0.008493619,
0.012783325,
0.004197313,
0.018755917,
-0.01653847,
-0.0054743257,
-0.017145628,
0.03415926,
-0.01812236,
0.009450554,
0.009252567,
-0.0050387555,
0.023085222,
-0.0063817636,
-0.0066556446,
-0.009239368,
-0.012466547,
0.02016822,
0.024880297,
0.014492609,
0.027401326,
0.032971345,
-0.01593131,
0.007483888,
-0.00074203673,
-0.011918785,
0.0013801306,
-0.041022792,
-0.00570201,
0.006078184,
-0.0010922253,
0.0016498872,
-0.0052532405,
-0.021144954,
-0.010506481,
0.0025474257,
0.044507354,
0.023309605,
-0.012558941,
-0.018293949,
-0.008110845,
0.009397757,
-0.020550994,
-0.0104008885,
-0.016842049,
-0.003613253,
0.013832654,
0.009087578,
-0.018399542,
-0.633979,
-0.010935452,
0.011766995,
-0.0057548066,
-0.01009071,
0.021105357,
-0.019046297,
-0.027216539,
-0.025461059,
0.029354792,
-0.008460621,
0.010942051,
0.020709384,
-0.0018660224,
-0.012829523,
-0.035479173,
-0.016604465,
-0.013093504,
0.033816088,
0.010249099,
-0.014109835,
0.0008934139,
0.001053453,
0.01960066,
0.0006244823,
0.037881408,
0.038250983,
-0.019112293,
0.008117445,
0.015033771,
-0.012110172,
0.0042336104,
-0.0061210813,
0.023045624,
0.0511861,
-0.009529748,
-0.022016093,
0.01491498,
0.022266876,
0.039438903,
-0.0068041347,
0.017779185,
0.037881408,
0.00042525842,
-0.029777164,
0.013093504,
0.017013635,
0.041761942,
0.008566214,
-0.0046526818,
-0.001856123,
-0.0028477053,
-0.015522138,
-0.011562409,
0.011793394,
0.027031751,
0.017937573,
-0.027216539,
0.007827065,
0.0033575203,
-0.032971345,
0.0057416074,
-0.014875382,
-0.0070417183,
-0.008553015,
-0.006507155,
0.0048605674,
0.0010476783,
0.007028519,
-0.0057779048,
0.0011771945,
0.03682548,
0.01242695,
0.021659719,
0.012684332,
0.026437791,
-0.006698542,
0.0026447691,
-0.008315431,
-0.002209199,
-0.019363075,
0.0032717262,
-0.00950335,
0.010460285,
0.021118555,
-0.001023755,
-0.03199461,
0.015456143,
-0.020762179,
0.019627057,
0.00168206,
-0.00907438,
-0.01723802,
-0.012037576,
-0.037617426,
0.019930637,
-0.0023807872,
0.005223543,
0.006490656,
-0.022755243,
-0.008203239,
-0.030859489,
0.0011433718,
-0.015324152,
-0.0065863496,
0.006929526,
-0.021250546,
-0.0038541364,
0.028536448,
-0.04265948,
-0.017805582,
-0.00526314,
-0.0006385063,
-0.0027421124,
-0.010057712,
-0.024801103,
0.0189935,
0.016828848,
-0.00789966,
-0.01667046,
0.019679854,
0.014215427,
0.00006780005,
-0.0006017963,
-0.006810734,
0.010486683,
-0.014796188,
-0.014149432,
0.014756591,
-0.02162012,
0.010882655,
-0.009285565,
0.017277619,
-0.030569108,
0.016432876,
-0.008790598,
0.036667094,
0.017528402,
0.02370558,
-0.025025489,
-0.024589919,
-0.007866662,
-0.004490993,
-0.02719014,
-0.009193171,
-0.00064139365,
-0.0059824907,
-0.0017703288,
0.005075053,
0.00657645,
-0.003933331,
-0.018333547,
-0.01374026,
0.023863968,
0.0045668874,
-0.013027509,
-0.006229974,
-0.0263058,
0.0054446277,
-0.026384994,
0.015073369,
0.009080979,
-0.013977844,
-0.009562746,
0.0049727596,
0.00482427,
0.005972591,
0.023124818,
0.0009255867,
-0.026371796,
-0.002705815,
-0.017198423,
-0.0072529037,
0.0044513955,
-0.00035121973,
-0.010334893,
0.0066292468,
-0.0010955251,
-0.013086905,
-0.012935115,
-0.0040554227,
-0.025461059,
0.006256372,
-0.0045668874,
0.007497087,
0.020419003,
0.016182093,
0.017884776,
0.011608606,
0.02327001,
-0.028721236,
-0.0066127474,
-0.026728172,
0.028694836,
0.004372201,
-0.00950335,
0.0066787433,
-0.00010399445,
-0.009886124,
0.006734839,
-0.003494461,
-0.027902892,
0.003334422,
-0.023151217,
0.0056228153,
-0.03228499,
-0.0018676722,
-0.007266103,
-0.002733863,
0.009100777,
0.0017950772,
0.016485672,
-0.008308832,
0.01565413,
0.0065434524,
0.02381117,
-0.00950995,
-0.013047308,
-0.0043788003,
-0.013542274,
0.008882992,
0.0002821307,
0.029196402,
0.016129296,
-0.0065500517,
0.009490151,
-0.0071275122,
0.012341156,
0.014558604,
-0.019481868,
-0.011720798,
-0.0035868546,
0.004695579,
-0.007384895,
-0.020828174,
0.012242163,
0.015838917,
-0.02821967,
0.036033534,
0.0030044445,
-0.019415872,
-0.0016894845,
0.021250546,
0.0049034646,
0.0018115761,
-0.014426613,
0.01707963,
-0.011780194,
-0.012888919,
0.014888582,
-0.0038673354,
0.03012034,
0.015178962,
-0.009998316,
0.008427624,
-0.005428129,
-0.002702515,
0.0010254049,
0.02689976,
0.021910502,
0.013265093,
-0.017224822,
-0.0029038014,
-0.025236674,
0.013832654,
0.019706251,
-0.013245294,
-0.01403064,
-0.0030935383,
-0.0043656016,
-0.0321794,
0.01126543,
0.018478736,
-0.02179171,
0.014796188,
0.009331762,
0.005131149,
0.016604465,
0.015733324,
0.0036297517,
-0.004161015,
-0.024167547,
0.028298864,
0.04358342,
-0.01797717,
-0.025065085,
-0.014109835,
-0.012433549,
0.005368733,
0.045378495,
0.019811844,
0.014360618,
0.019825043,
-0.001213492,
-0.0017670292,
-0.0053291353,
0.02691296,
-0.025355466,
0.013713862,
-0.003172733,
-0.022478063,
-0.011483215,
0.004695579,
-0.007959056,
0.05617536,
0.001097175,
-0.0037650424,
-0.006764537,
0.019943835,
-0.008269235,
-0.005457827,
-0.010011516,
0.006500555,
-0.0062035755,
-0.007589481,
0.0057218084,
0.00803165,
0.013977844,
0.013713862,
-0.0131594995,
-0.01562773,
-0.03745904,
-0.014624599,
0.021105357,
0.022702446,
0.017765984,
-0.008935789,
0.02135614,
-0.014057038,
-0.009371359,
-0.010605475,
-0.025711842,
0.024484325,
0.008381426,
0.003831038,
-0.009727734,
-0.0011912185,
-0.00054363784,
-0.009443954,
0.0029714468,
0.00070656417,
-0.020023031,
-0.0003126536,
-0.0024022358,
0.010552678,
0.009674938,
0.032100204,
0.03302414,
-0.0053852317,
0.00921297,
0.0072001074,
0.034555238,
0.0038343377,
-0.011272029,
-0.00079112087,
0.00818344,
0.017053233,
0.0003937043,
0.0054941243,
-0.017805582,
0.012090373,
0.010843058,
0.0021135055,
0.005692111,
0.015231758,
0.023652783,
0.027770901,
-0.008520017,
0.008731203,
-0.0036792483,
0.012994511,
0.012400552,
0.0007836964,
-0.02543466,
0.025764637,
-0.0351096,
-0.0021448534,
-0.015416546,
0.0024286339,
-0.0038046397,
-0.00007048112,
-0.018914307,
-0.00057952286,
-0.034924813,
0.004926563,
-0.016446074,
0.006375164,
0.005292838,
0.0019666655,
-0.0010551028,
0.022583656,
-0.008783999,
-0.018056365,
-0.02732213,
0.017317215,
-0.025830634,
-0.022148086,
0.010348092,
0.031466648,
0.012697532,
0.019561062,
-0.0131661,
0.0043919994,
-0.0056195157,
-0.0032849254,
-0.0037188455,
0.008856595,
-0.029354792,
-0.017066432,
-0.011054244,
0.02162012,
-0.024787905,
-0.0036594498,
0.015561735,
0.005127849,
0.029275598,
0.021540927,
0.004487693,
-0.0062167747,
0.003011044,
0.022768443,
0.031704232,
-0.011377621,
-0.020432202,
0.011701,
-0.008025051,
-0.0038475369,
-0.016578065,
-0.024061954,
-0.011753796,
0.006160679,
0.007173709,
-0.019917438,
0.0027454123,
0.019693052,
-0.011912185,
0.021659719,
0.021422135,
0.025923027,
0.029988348,
-0.0054611266,
0.0038079396,
0.015099767,
-0.02617381,
0.0022999428,
-0.021144954,
0.008685006,
0.013344287,
-0.00017416621,
0.01286252,
0.012149769,
-0.0204454,
-0.013859052,
0.013634668,
-0.015139365,
0.024537122,
0.008783999,
-0.01958746,
-0.017330414,
-0.0052664396,
-0.02018142,
0.0028394558,
0.008011852,
-0.01841274,
-0.014677396,
0.0043623014,
0.01067807,
-0.022557257,
0.013793057,
-0.026675375,
-0.006332267,
0.030569108,
-0.005919795,
-0.017449206,
-0.024220344,
0.0015038721,
0.004712078,
-0.011470015,
-0.005603017,
-0.041603554,
0.010354692,
-0.025936225,
0.042738676,
0.013713862,
0.04123398,
-0.007470689,
0.013482878,
0.007939257,
-0.00016158582,
0.0071869083,
-0.010486683,
0.026622579,
-0.017304016,
-0.0006946025,
0.02660938,
-0.01957426,
0.012176167,
-0.02061699,
0.0011186235,
0.030595507,
-0.018465538,
0.007193508,
0.00789306,
-0.02237247,
-0.029038014,
0.009734334,
-0.013113303,
0.019917438,
-0.033446513,
-0.012539143,
0.020115424,
-0.0064444593,
0.0035637561,
-0.010255698,
0.0067018415,
-0.039386105,
0.031651434,
-0.010737466,
0.020326609,
-0.03315613,
0.0025259773,
-0.0001367344,
-0.002951648,
0.010268898,
0.0017604296,
0.016353682,
0.003159534,
-0.009523149,
0.0137666585,
0.0067018415,
-0.022887234,
-0.0048803664,
-0.017224822,
-0.01403064,
-0.012149769,
-0.023877166,
-0.004985959,
-0.04165635,
0.021224149,
0.016050102,
0.008698205,
0.0233756,
0.007134112,
-0.03233779,
0.023692379,
0.0022834437,
0.029988348,
-0.023283208,
0.027374927,
0.017356813,
-0.0011235732,
-0.033657696,
-0.015178962,
0.00892259,
0.0024583319,
0.03012034,
0.016287686,
-0.020643389,
-0.0006743914,
0.00980033,
0.027744502,
-0.01651207,
-0.012011179,
-0.004989259,
-0.025685443,
0.002004613,
0.0028757532,
-0.0066160476,
-0.005365433,
-0.016723257,
-0.012242163,
0.0032057308,
-0.016710058,
-0.0031067375,
-0.028140476,
0.014492609,
-0.011747196,
-0.0061804773,
0.011733998,
-0.0052268426,
-0.010150106,
-0.00803165,
-0.019125491,
0.012525943,
-0.0059692916,
0.030912286,
0.0060319873,
0.012400552,
0.010638473,
-0.019125491,
-0.012895518,
-0.01696084,
-0.014109835,
0.040653218,
-0.01974585,
0.0012959864,
-0.00054899993,
0.0011219232,
-0.0036000537,
-0.008315431,
-0.0058472,
0.0016408127,
-0.008948988,
-0.009661739,
0.028615642,
0.009747533,
-0.0054710256,
0.009991717,
-0.021870904,
-0.009483552,
-0.021224149,
-0.030093942,
0.009905922,
-0.06420041,
0.004754975,
0.0070087207,
0.018689921,
0.00950995,
0.02090737,
-0.011027846,
-0.0036033536,
0.044665746,
-0.028615642,
0.016789252,
0.012096972,
-0.003494461,
-0.02763891,
0.008579413,
0.0019171688,
-0.030199533,
0.00041969004,
-0.029961951,
-0.020973366,
0.005147648,
-0.016868446,
0.0027685107,
0.015310952,
-0.034449644,
0.010717667,
0.0010617024,
0.016855247,
-0.00028274942,
0.0045041917,
0.03640311,
-0.01825435,
0.00013405333,
0.019244283,
-0.002892252,
0.005513923,
0.010882655,
-0.007325499,
0.008256035,
-0.017871577,
-0.01942907,
-0.005866999,
0.0056195157,
-0.011760396,
0.013251893,
-0.011225832,
-0.00964854,
-0.013859052,
0.026187008,
0.010156705,
-0.023441596,
-0.013496077,
0.024405131,
0.0032519277,
0.023164416,
-0.013674265,
0.008249436,
0.02382437,
-0.046460822,
-0.042025924,
0.014387016,
-0.012195966,
0.038514964,
0.008223037,
-0.024893498,
-0.022029294,
0.0047285766,
-0.043029055,
-0.02327001,
-0.003040742,
0.024497524,
-0.023586787,
0.00091156265,
-0.005075053,
-0.009397757,
-0.010354692,
0.021884102,
0.00071522605,
-0.033816088,
0.025302669,
0.014347418,
0.022491261,
-0.016551668,
-0.019547863,
-0.005457827,
0.02455032,
0.0038904338,
-0.012829523,
0.040415637,
-0.026675375,
0.018940704,
-0.009476951,
0.03130826,
0.002441833,
0.021078957,
0.010473483,
-0.002570524,
-0.011159836,
0.0021861005,
0.0115558095,
-0.00409172,
0.025381863,
0.010156705,
0.005919795,
0.0029796963,
-0.011727398,
-0.0046130843,
0.025975823,
-0.01300111,
0.026794167,
0.016459275,
-0.0029730967,
0.01723802,
0.010572477,
0.0035505572,
-0.009641941,
-0.022253677,
-0.023322804,
0.003596754,
0.02543466,
0.0109288525,
0.00065129297,
0.005081652,
-0.020432202,
-0.008566214,
-0.00043928245,
-0.010328294,
-0.032153,
-0.023890365,
0.0037089463,
-0.017633993,
-0.0044975923,
-0.018874709,
-0.0006079834,
-0.0018429239,
-0.032100204,
-0.004441496,
0.0075168856,
-0.008698205,
-0.0204454,
-0.01636688,
-0.025236674,
-0.014637799,
-0.022055691,
-0.011608606,
0.008401225,
0.019402673,
0.19101733,
-0.012156368,
-0.004461295,
0.005866999,
-0.0074640894,
-0.008612411,
0.0062926696,
-0.011245631,
-0.021250546,
0.0035604564,
0.028246067,
-0.0032931748,
-0.01140402,
0.00803165,
0.004985959,
-0.017897977,
-0.020089027,
0.015046971,
-0.030489914,
-0.006342166,
0.022438465,
-0.009905922,
0.007087915,
0.00759608,
0.049892586,
0.0025787735,
-0.031387452,
0.010598875,
0.02732213,
0.006048486,
-0.02381117,
0.014426613,
-0.004926563,
-0.0022273476,
0.00046031852,
-0.008394626,
0.013350886,
-0.0064741573,
0.025962625,
0.013139701,
0.013185898,
-0.006757938,
-0.019613858,
0.0011392471,
0.010585676,
0.012875719,
-0.000119307464,
-0.004926563,
-0.011120239,
-0.0069229263,
-0.01828075,
0.013317889,
0.011166437,
0.040151652,
0.014928179,
-0.007503687,
0.008638809,
0.014492609,
-0.0056822114,
0.013430081,
-0.0059593925,
0.016472474,
-0.03130826,
0.008790598,
-0.003319573,
0.040283643,
-0.009113977,
0.008262635,
0.023006026,
-0.030885886,
-0.01696084,
-0.00043309538,
-0.0074772886,
0.0041181184,
-0.012737129,
-0.02674137,
0.027216539,
0.015178962,
0.015020573,
0.028457254,
0.01667046,
-0.016630862,
-0.04999818,
0.0030753897,
-0.009338361,
-0.015271355,
0.010750664,
0.0120639745,
-0.031968214,
-0.032812957,
0.0149017805,
-0.0041775145,
-0.010691268,
0.00017674416,
0.024365533,
-0.004154416,
-0.00380134,
0.02061699,
-0.013647866,
-0.0073584965,
-0.028272467,
0.045167312,
-0.003040742,
0.026596181,
0.005101451,
0.024048755,
-0.017950771,
0.003494461,
-0.00097178353,
-0.015112966,
0.032707363,
-0.00409172,
0.014109835,
-0.00847382,
0.0024929794,
0.001330634,
0.024959493,
-0.0190199,
0.006823933,
-0.012050776,
-0.005015657,
-0.0073057003,
0.02589663,
0.029513182,
-0.021303343,
0.015363749,
-0.034977607,
0.0126513345,
-0.012954914,
-0.039095726,
0.011766995,
-0.0031182866,
0.015337351,
0.018214755,
0.014637799,
-0.02381117,
-0.006563251,
-0.0027982085,
-0.018848311,
0.011602006,
0.005249941,
-0.014585002,
0.018478736,
-0.001125223,
-0.010202902,
-0.014004242,
0.028906023,
0.0102227,
-0.014848984,
0.004302906,
-0.008506818,
-0.019693052,
-0.0021415534,
-0.0155089395,
0.021171352,
-0.041154783,
-0.009899323,
0.0025523754,
0.010493282,
-0.009747533,
-0.016195292,
0.004718677,
0.0010773763,
-0.011001447,
0.0015731674,
0.000108273845,
-0.16620304,
-0.001359507,
0.0075762817,
-0.01797717,
0.018544732,
0.025408262,
0.00041144062,
-0.0017917774,
0.0026183708,
0.02179171,
0.036957473,
0.0054248287,
-0.04735836,
-0.037775815,
-0.0037485436,
-0.016155696,
-0.03233779,
0.028272467,
0.024325935,
0.012202566,
0.01944227,
-0.019455468,
0.012624936,
0.0035439576,
0.0041346173,
-0.0004619684,
0.020366207,
-0.027137343,
-0.0063982625,
-0.024365533,
-0.010493282,
0.009034782,
0.019693052,
-0.0024929794,
-0.0057515064,
0.0037617427,
0.0066028484,
-0.013793057,
-0.016419677,
0.020234216,
0.018016767,
0.03144025,
-0.0024946295,
0.008302232,
-0.01593131,
0.050341357,
-0.018795514,
-0.010763864,
0.024880297,
0.00013364086,
0.02602862,
-0.011799993,
0.007193508,
0.011958382,
0.028589245,
-0.014716993,
-0.01942907,
0.009767332,
-0.006226674,
-0.0014634499,
-0.004210512,
-0.014400215,
0.011192834,
-0.006962524,
0.022610053,
-0.023890365,
-0.016789252,
0.019217886,
-0.032575373,
-0.008704805,
-0.01812236,
-0.023336004,
0.020880971,
-0.0053489343,
0.024391932,
0.011483215,
-0.020419003,
-0.009041382,
-0.00085134176,
-0.0038838342,
-0.015442943,
0.024127949,
-0.017317215,
-0.010843058,
-0.019389473,
0.015469342,
-0.008731203,
0.016842049,
-0.0131792985,
-0.009542948,
0.024510723,
-0.015614532,
-0.025263071,
-0.00993892,
0.03157224,
0.01271733,
-0.011588807,
-0.006493956,
-0.020762179,
0.024761505,
0.025421461,
-0.018465538,
-0.024761505,
0.0034581635,
0.053456344,
0.0009008384,
-0.023058822,
0.0190067,
0.06488676,
-0.015601333,
0.0023114919,
-0.010783662,
0.011978181,
0.011931984,
-0.004286407,
0.0248539,
-0.009014984,
-0.011489814,
0.03204741,
-0.040046062,
0.065256335,
-0.0032288292,
0.0057086097,
0.025249872,
-0.024919895,
-0.0030291928,
-0.11013327,
-0.00789966,
0.014716993,
0.007846863,
-0.019547863,
0.01125223,
-0.008249436,
0.013053907,
0.015891712,
0.020128623,
-0.009087578,
0.008157042,
0.00745749,
0.0025375264,
0.013713862,
0.024893498,
0.016142495,
-0.012294959,
-0.032073807,
0.03711586,
0.0045833867,
0.010394289,
-0.015469342,
-0.01812236,
-0.00921297,
-0.0007032644,
-0.042316306,
0.029407589,
0.012750328,
0.010037913,
0.0027949088,
-0.028536448,
0.03157224,
-0.0013652816,
-0.02425994,
-0.024022358,
0.0010476783,
-0.0038376376,
0.045167312,
-0.015258157,
-0.0041049193,
0.005134449,
-0.01841274,
-0.007939257,
0.008711404,
0.0016606114,
-0.027137343,
0.011503013,
0.02427314,
-0.0008785649,
-0.020498198,
-0.04851988,
-0.041524358,
-0.0044678943,
0.018452337,
-0.02472191,
0.016406478,
0.020432202,
-0.028906023,
-0.0081306435,
0.014637799,
0.0005106401,
0.004190713,
-0.013086905,
0.013324489,
0.006823933,
-0.01198478,
-0.031176267,
0.027665308,
-0.029433986,
-0.012783325,
0.0072991005,
-0.010717667,
0.0026398194,
-0.028457254,
0.0037155459,
-0.042949863,
-0.010994848,
0.011120239,
-0.041709147,
-0.005187245,
-0.006975723,
0.00949675,
-0.015997306,
0.024352334,
0.026675375,
0.002953298,
-0.016142495,
0.0030324925,
-0.018795514,
-0.026662176,
0.036059935,
0.0042930064,
0.00018911832,
-0.033842485,
0.014400215,
0.00040607847,
-0.0062200744,
0.013311289,
0.021065759,
-0.015944509,
-0.031176267,
-0.058709584,
-0.009760733,
-0.00010203521,
-0.01593131,
-0.0042633084,
-0.009965318,
0.025408262,
0.009391158,
0.0064444593,
0.025645847,
0.00060880836,
0.023586787,
-0.02148813,
0.017871577,
-0.025223475,
-0.016208492,
0.0131792985,
0.004032324,
0.036772683,
0.033868883,
0.009186571,
0.00336247,
-0.0056888107,
0.015284554,
-0.038224585,
-0.014545405,
-0.02556665,
0.006259672,
-0.008671807,
-0.016551668,
-0.0047846725,
-0.055594597,
-0.020550994,
0.0030258931,
-0.0058933967,
-0.03569036,
0.0025820734,
0.014083437,
0.0114766145,
0.019772248,
-0.004210512,
-0.025923027,
0.009859726,
0.016630862,
-0.0014238526,
-0.0042996057,
-0.022900434,
0.007959056,
0.011390821,
0.007226506,
0.033657696,
-0.004197313,
0.020287013,
-0.021474931,
-0.0063685644,
0.014650998,
0.014532206,
-0.01886151,
0.0069493246,
-0.011206034,
0.0336313,
0.01990424,
0.013410282,
-0.004227011,
-0.012624936,
-0.009371359,
-0.022174483,
-0.008896192,
0.015442943,
-0.027110945,
-0.026635777,
0.00701532,
-0.0012217414,
0.014941378,
0.017330414,
0.0024467825,
-0.021950098,
-0.0051245494,
-0.026226606,
0.030331526,
0.012935115,
-0.020484999,
0.00002263439,
-0.016749654,
0.028404457,
0.001870972,
-0.008876393,
0.015165763,
0.018769115,
0.018848311,
-0.022847638,
0.011588807,
-0.011951783,
-0.0017653792,
0.01476979,
-0.00028584295,
-0.0087971985,
0.011879187,
-0.013621468,
0.03376329,
-0.0022867436,
-0.009490151,
0.008810397,
-0.0052070436,
-0.010255698,
0.0045932857,
-0.0036660493,
-0.020141821,
-0.00051971443,
0.007483888,
0.021659719,
-0.009186571,
-0.023784773,
0.0040455232,
-0.013106704,
-0.0010773763,
-0.01916509,
-0.007648877,
-0.0055898177,
0.042817872,
0.00599239,
0.021976497,
0.0029318496,
-0.0032502776,
0.0011012997,
-0.00034049546,
0.02469551,
-0.008856595,
0.024655914,
-0.019402673,
0.0051542474,
0.042501092,
-0.021857705,
-0.019627057,
0.021725714,
0.007813865,
0.024497524,
0.014756591,
-0.015865315,
0.094663925,
0.003260177,
-0.046592813,
0.0071407114,
-0.0063916626,
0.023349203,
0.0024913296,
-0.002207549,
-0.019534664,
-0.029143607,
-0.0007465739,
-0.034740023,
0.01871632,
-0.030173136,
-0.037036665,
0.018887907,
0.020788578,
0.010183103,
0.00058653485,
-0.008242836,
0.011107041,
-0.020353008,
0.014057038,
0.018518332,
-0.04149796,
-0.0025688743,
0.059448734,
0.005101451,
0.01725122,
-0.007807266,
-0.00041556533,
-0.009582545,
-0.019072695,
0.012928516,
0.016129296,
-0.022874035,
0.005837301,
-0.031202666,
0.008803798,
0.007912858,
0.009259166,
0.007972254,
-0.0044942927,
-0.010975049,
0.013357487,
-0.0046427823,
-0.006856931,
0.000003615573,
-0.014281423
] |
Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder often characterized by severe neurodevelopmental abnormalities and neuro-retinal degeneration. Mutations in the TRPML1 gene are causative for MLIV. We used lead optimization strategies to identify--and MLIV patient fibroblasts to test--small-molecule activators for their potential to restore TRPML1 mutant channel function. Using the whole-lysosome planar patch-clamp technique, we found that activation of MLIV mutant isoforms by the endogenous ligand PI(3,5)P2 is | [
-0.02256213,
0.0058026556,
0.013638604,
-0.027155617,
-0.0314789,
0.019360198,
-0.0039112195,
-0.0029452362,
-0.00008406969,
0.012301089,
0.0230485,
0.008133175,
-0.0072077224,
0.0052453573,
-0.018806279,
-0.00078021735,
0.017185047,
-0.0050359485,
0.009963815,
0.010463694,
-0.01840097,
0.026385533,
-0.018211827,
-0.048501823,
0.01522606,
-0.008545238,
0.0027577812,
-0.051717263,
-0.010936554,
0.00030018104,
0.007775153,
-0.0075927647,
0.021184083,
-0.004829917,
0.015996145,
-0.025034506,
0.017576845,
-0.016928352,
0.005873584,
-0.017820029,
0.030830408,
0.02307552,
-0.0021903506,
0.008531728,
-0.024075279,
0.00006121835,
-0.01938722,
-0.011895781,
-0.0099435495,
0.010159713,
0.021170573,
0.008410135,
0.02362944,
-0.011990353,
0.0007084441,
0.0020366714,
0.019589873,
-0.006218096,
-0.019252116,
-0.029155135,
-0.009173465,
0.0037322086,
-0.03353246,
0.021427268,
0.0033049467,
0.021751514,
-0.010132693,
0.023170091,
-0.0011449943,
0.009213995,
0.027966233,
0.0110919215,
-0.013848013,
-0.010450184,
0.03774766,
-0.012544273,
-0.012199762,
-0.025358753,
-0.0068497006,
0.009734141,
0.018819788,
0.0073968656,
-0.006964538,
0.029209176,
0.013057664,
-0.0006337155,
0.022643192,
0.03312715,
0.0064916788,
-0.002791557,
0.0021346207,
0.007835949,
0.012800968,
0.0052588675,
-0.011058145,
0.009308567,
0.007727867,
0.020197835,
0.0029503023,
-0.019265627,
-0.0147802215,
0.012098435,
-0.02888493,
-0.013334624,
-0.022440538,
0.0014675517,
-0.011375637,
0.014874794,
0.029749587,
0.006944272,
-0.005100122,
0.024413034,
0.0009558507,
-0.032478657,
0.025439814,
-0.0064984336,
0.02579108,
0.025277691,
-0.0069915582,
-0.019265627,
0.017468762,
0.021575881,
0.0077346223,
-0.009112668,
0.011409412,
-0.013679136,
-0.019846568,
-0.013442706,
-0.024318462,
0.0008975877,
0.025561407,
0.00604584,
0.007883235,
-0.012030884,
-0.00891677,
0.005086612,
-0.026574675,
-0.008410135,
-0.024845364,
-0.013388664,
0.0024065145,
0.020657184,
-0.020940898,
0.0177795,
-0.00027104953,
0.0071671912,
0.007991317,
0.0024554892,
0.009653078,
-0.016090717,
0.012794213,
-0.01992763,
0.0041138735,
-0.002379494,
0.01676623,
0.026385533,
0.0067551285,
0.008855973,
-0.029209176,
-0.018711707,
-0.011990353,
-0.02000869,
-0.010125938,
0.018563094,
0.010112427,
0.020265386,
0.02368348,
-0.0015579015,
0.0070591094,
0.005468277,
0.0077548875,
0.025520876,
-0.040125463,
0.023480827,
-0.019481791,
0.015928593,
-0.00021721961,
-0.0065389643,
-0.013827749,
-0.00866683,
-0.012368641,
0.037018105,
0.020886857,
-0.012733418,
-0.000063434876,
0.020724734,
0.019346688,
-0.013064419,
-0.0018424613,
-0.037153207,
0.0050021727,
0.0031597114,
-0.013044153,
-0.020765265,
-0.6381165,
-0.03504561,
0.011227024,
0.00080597127,
-0.009159954,
0.041989878,
0.0048231618,
-0.01232811,
0.0018340175,
0.010004345,
0.014280342,
0.02834452,
0.00010048254,
-0.023494337,
-0.00093896285,
-0.019779017,
-0.012969847,
-0.017887581,
0.028722806,
0.0033623653,
-0.035261773,
-0.005323041,
-0.006164055,
0.019751996,
-0.0025399283,
0.019697955,
0.029641503,
-0.017536314,
-0.009085648,
0.013604829,
-0.013489991,
0.015996145,
-0.011186493,
0.0019167678,
0.05033922,
-0.013875034,
-0.015874552,
0.03580218,
0.026426064,
0.025872143,
-0.021170573,
0.01787407,
0.0078021735,
-0.005100122,
-0.024602178,
0.031586982,
-0.0015629679,
0.024480587,
0.01941424,
-0.00059234037,
0.00046610387,
0.0005990955,
-0.021927148,
0.0032593496,
0.022170331,
-0.0023693615,
0.012591559,
-0.006495056,
0.01683378,
0.0036477693,
-0.0024892648,
0.008950545,
-0.007984562,
0.0068497006,
-0.01257805,
-0.014969365,
-0.011747168,
0.006055973,
0.00035654413,
-0.01682027,
0.0067551285,
0.023021478,
-0.002210616,
0.013071174,
0.014145239,
0.02416985,
-0.009673344,
0.03453222,
-0.012713152,
0.012976602,
0.025764061,
-0.01080145,
-0.01996816,
0.002092401,
0.021697473,
0.017495783,
-0.02104898,
0.02254862,
-0.012598315,
0.004792764,
0.021562371,
0.0020653806,
-0.0029097716,
-0.03782872,
-0.042152002,
0.017009413,
-0.01418577,
0.008180461,
-0.024223892,
0.0001554735,
-0.012902295,
-0.012280824,
0.012875275,
-0.004860315,
0.031127632,
0.006410617,
-0.04671847,
-0.0010791318,
0.025696509,
-0.03466732,
-0.0008030159,
-0.0040024137,
0.006413995,
-0.0046306406,
-0.0039585056,
-0.02096792,
0.0038504233,
-0.009565262,
-0.022953928,
-0.021373227,
0.004397589,
-0.006751751,
0.007200967,
0.024061767,
-0.020035712,
-0.0052723777,
0.018563094,
-0.024521116,
0.0036477693,
0.017644396,
-0.018076723,
-0.0033944522,
0.030317018,
-0.01080145,
0.021805555,
0.009328833,
0.038125947,
-0.0012758749,
-0.0052487347,
0.0027358271,
-0.015266591,
-0.004549579,
-0.008977566,
0.0050731017,
0.0026919188,
-0.012395661,
-0.00069577823,
-0.004161159,
-0.0005264778,
-0.012199762,
-0.016374432,
0.011517494,
0.006207963,
0.023278173,
0.014347893,
-0.0084506655,
-0.013625095,
-0.015996145,
-0.0011635709,
-0.00998408,
-0.005400725,
-0.009355853,
0.008315563,
0.014820752,
0.0059445133,
-0.023751032,
0.01469916,
0.01181472,
-0.01209168,
-0.0154287135,
-0.01469916,
-0.023845604,
-0.0267368,
0.0023997594,
-0.019806037,
0.016509535,
0.022994457,
-0.012814479,
-0.008761402,
-0.005177806,
-0.0021515083,
-0.015361163,
0.0073833554,
0.021332696,
0.003597106,
0.024534628,
0.024926424,
-0.0037896272,
0.007822439,
0.033883724,
0.006859833,
0.041314367,
0.014982875,
0.01582051,
-0.0024757546,
0.013104949,
0.008950545,
0.00604584,
0.0034924014,
0.016036674,
-0.0019285892,
-0.016941862,
0.02416985,
-0.019630404,
0.020062732,
-0.024804832,
-0.0078021735,
-0.03407287,
0.01786056,
0.0035565752,
0.0050190603,
0.035613038,
0.00007842282,
-0.004444875,
-0.0003698433,
0.019360198,
0.017239088,
-0.022913396,
-0.0026936075,
-0.02465622,
0.000569964,
0.0020282273,
0.007153681,
0.00997057,
0.0012041017,
0.019616893,
-0.009923284,
0.020873347,
-0.005309531,
-0.02095441,
-0.010416408,
0.006829435,
0.03101955,
0.016482513,
0.0014042223,
0.014834262,
0.01156478,
-0.010977084,
0.032965027,
0.005400725,
0.0053703273,
0.027277209,
-0.006505189,
0.010551511,
0.005579736,
-0.027128596,
0.013848013,
0.018117255,
-0.011693127,
0.013199521,
-0.010686614,
0.02208927,
-0.015942104,
-0.011652597,
-0.00282871,
-0.016698677,
0.007667071,
0.022345966,
0.02947938,
0.012976602,
0.013956096,
-0.0105447555,
-0.015590837,
0.001852594,
-0.0051913164,
0.0008958989,
-0.006937517,
-0.008761402,
-0.0036004835,
-0.020805797,
-0.016968884,
-0.0102948155,
0.003325212,
-0.049231376,
0.009268036,
0.0020687582,
0.0044752727,
0.010821716,
0.017887581,
0.010470449,
0.0032779262,
-0.04839374,
0.019643914,
0.014523527,
-0.016144758,
-0.0009820268,
-0.038639337,
0.011328351,
-0.00063667085,
0.0020417375,
0.0069915582,
0.008004827,
0.015861042,
0.009842223,
-0.0154287135,
-0.01886032,
0.034289032,
-0.020427508,
0.01469916,
-0.013327869,
-0.006964538,
0.02365646,
-0.0036173714,
-0.004086853,
0.037558515,
0.012260558,
-0.024061767,
0.009186975,
-0.0060492177,
-0.032262493,
-0.007883235,
-0.012733418,
0.0018627268,
-0.00812642,
-0.022845846,
0.005231847,
-0.005549338,
0.0008148374,
0.03942293,
-0.005177806,
-0.018995421,
-0.034802422,
0.0049650194,
0.0006590472,
0.0038436681,
0.026912432,
0.005512185,
0.008288543,
0.013429196,
0.0068497006,
0.0120376395,
-0.03164102,
0.0073158043,
-0.0059681563,
-0.0021059113,
-0.005535828,
0.0024521116,
0.0067551285,
0.0060829935,
0.02052208,
0.005302776,
-0.02419687,
-0.005502052,
0.0053601945,
0.018333418,
-0.019495301,
0.0028658633,
0.0314789,
0.019468281,
-0.015969124,
0.0030803387,
0.022197353,
0.00081019325,
-0.021170573,
-0.012057904,
-0.0060357074,
-0.008842464,
0.029101094,
-0.0030009658,
-0.028533664,
0.01522606,
0.00870736,
0.0052386024,
0.030127874,
0.004140894,
0.0046171304,
-0.003597106,
0.012996867,
0.006626781,
0.000073462026,
-0.031046571,
0.0013780462,
0.01130133,
-0.008457421,
0.041233305,
-0.0052521126,
0.0001841828,
0.005333174,
0.024223892,
-0.005086612,
0.007552234,
-0.01938722,
0.020873347,
-0.01784705,
0.009632814,
-0.03099253,
-0.007606275,
-0.003100604,
0.014280342,
-0.0062620044,
-0.0077143568,
-0.00922075,
-0.011659352,
-0.027182637,
0.0013113393,
-0.01784705,
-0.009234261,
0.0114431875,
-0.017630886,
0.016374432,
0.004644151,
-0.01311846,
0.01569892,
0.03355948,
-0.02095441,
-0.011017615,
0.00592087,
-0.012010619,
0.003972016,
0.018981911,
0.0022376364,
-0.029074073,
-0.009423404,
0.01888734,
0.014320873,
-0.02419687,
0.00841689,
0.011260799,
-0.019724976,
0.00068311236,
0.032181434,
0.014969365,
-0.026547655,
-0.0045158034,
0.0007840171,
-0.033343315,
-0.038477212,
-0.04344899,
-0.032181434,
-0.003115803,
-0.0043739458,
0.010740655,
-0.0045394464,
-0.00056278665,
0.00022650791,
0.008788423,
0.004488783,
-0.0079035,
0.016212309,
0.033721603,
-0.0012336554,
0.018576603,
0.009308567,
-0.025669489,
0.00039454174,
-0.03466732,
0.02466973,
-0.014577568,
-0.022859355,
0.020049222,
0.022210862,
-0.027101576,
-0.0061944528,
-0.004674549,
0.012193007,
0.047096755,
0.00048890244,
-0.022467557,
-0.022791805,
-0.001526659,
-0.027412312,
0.0037659842,
-0.008038603,
-0.015861042,
-0.0005488542,
0.016414963,
-0.0020569367,
-0.009909773,
0.02573704,
-0.031830166,
-0.00947069,
0.017455252,
-0.010950063,
0.0025770816,
-0.0139831165,
0.0137331765,
-0.021562371,
-0.017603865,
-0.022697233,
-0.008497952,
0.008943791,
-0.021386737,
0.03985526,
0.025588427,
0.03482944,
0.0026733421,
0.01787407,
-0.0016229197,
0.018725216,
0.01729313,
-0.0071807015,
0.0006349821,
-0.020940898,
0.02369699,
0.024750791,
-0.006694332,
0.04890713,
-0.026952963,
0.025061527,
0.025926184,
-0.021778535,
-0.019779017,
0.010659593,
-0.023899645,
-0.01419928,
0.021170573,
-0.0019285892,
-0.0015477688,
-0.03772064,
-0.010619062,
0.010071897,
0.010713634,
-0.0179146,
0.0007054887,
0.028668765,
-0.02362944,
0.045421485,
-0.006998313,
0.011598555,
0.004917734,
-0.017401211,
0.003310013,
-0.017063456,
-0.0087006055,
-0.012145721,
0.019346688,
0.0016617617,
-0.0027544037,
-0.022170331,
-0.0033826306,
-0.015185529,
-0.024061767,
-0.01260507,
-0.015401693,
-0.022440538,
-0.025183119,
-0.0025922805,
-0.049015213,
0.01209168,
0.01417226,
-0.013969606,
0.030722326,
-0.023521358,
-0.0003016587,
0.020832816,
0.0025990356,
0.008910014,
-0.015969124,
0.031938247,
0.018455012,
0.0045158034,
-0.0216029,
0.008734381,
0.01128782,
-0.0041983123,
0.04577275,
0.025966715,
-0.018549584,
-0.01792811,
0.012165987,
-0.018198317,
-0.029182155,
-0.046934634,
0.007417131,
0.0024706882,
0.018563094,
0.006177565,
-0.0074779275,
-0.046988674,
0.02361593,
-0.030073833,
0.019495301,
-0.017995663,
0.004870448,
-0.027344761,
0.03682896,
0.0040091686,
-0.0024858874,
0.0022545243,
-0.006106636,
0.009659834,
-0.02572353,
-0.012632091,
0.0006480701,
-0.006518699,
0.03453222,
0.0028118223,
0.006883476,
-0.0077886633,
0.010267795,
0.017144516,
-0.023764543,
-0.0055864914,
0.044556826,
-0.009680099,
0.0135372775,
-0.000096207805,
0.0034231613,
-0.0063599534,
-0.01945477,
0.0005961401,
-0.022210862,
-0.027696026,
-0.021170573,
0.026088307,
0.010038121,
-0.011949822,
0.009821957,
-0.020386979,
-0.0026311225,
-0.033397354,
-0.029533422,
0.016968884,
-0.04877203,
-0.009774671,
-0.01886032,
-0.00027928234,
0.01938722,
-0.017711947,
-0.004397589,
-0.007437397,
0.0400444,
-0.028101334,
0.016225819,
-0.0022916773,
-0.0023845604,
-0.019062974,
0.001014958,
-0.005410858,
-0.01792811,
0.0059782886,
-0.01999518,
-0.022805315,
-0.012915806,
-0.01522606,
-0.004357058,
-0.0025990356,
-0.0007738844,
0.023089029,
-0.023926666,
0.025088547,
0.0067551285,
-0.0035295547,
0.02468324,
-0.032938007,
0.024764301,
-0.009004586,
0.010666348,
-0.019495301,
0.024264421,
-0.00007261763,
-0.009612548,
-0.012247048,
0.00094402925,
-0.0027155618,
-0.01155127,
-0.010125938,
0.004995418,
-0.008268277,
-0.0077954186,
-0.022967437,
0.0073158043,
0.021832576,
-0.02466973,
-0.023413276,
0.0064308825,
0.007721112,
-0.0024689995,
-0.023548378,
-0.014050667,
0.00087478914,
-0.012226783,
0.0024689995,
-0.014469486,
-0.023845604,
0.065173484,
0.0062282286,
0.0011863695,
-0.00920724,
0.009403139,
-0.04577275,
-0.0040564546,
-0.008342584,
-0.0115918005,
-0.005343307,
0.012929316,
-0.018644154,
0.00840338,
-0.011531005,
0.016914843,
0.004488783,
0.0053737047,
0.014347893,
-0.008092644,
0.043530047,
-0.014104708,
-0.0113418605,
-0.015077447,
0.016036674,
0.005265623,
0.009315322,
0.030100852,
-0.026439574,
-0.0029807005,
-0.011213513,
0.04053077,
0.019103503,
0.008585769,
0.017549824,
-0.0052487347,
-0.01415875,
0.0026463217,
0.011686373,
-0.0050731017,
0.010342102,
-0.0036004835,
0.025966715,
0.00012539208,
-0.00054083247,
-0.0230485,
-0.0040193014,
-0.022224372,
0.018522562,
0.010382633,
-0.004961642,
-0.0074981926,
0.011348616,
-0.0021379981,
-0.0058566965,
0.019117014,
-0.01999518,
-0.00918022,
0.0010335346,
0.0058431863,
-0.012125456,
0.008322318,
0.003154645,
-0.01887383,
-0.014942344,
0.006964538,
-0.01314548,
-0.02934428,
0.020346448,
-0.029803628,
-0.03204633,
-0.033262253,
-0.001209168,
-0.01467214,
0.01232811,
0.001066466,
0.025102058,
-0.0063396883,
-0.014901814,
-0.0068902313,
-0.018954892,
-0.012564539,
0.018684685,
-0.04890713,
-0.030965509,
0.023210622,
0.18871127,
-0.019238606,
0.014253321,
0.0027712914,
-0.005262245,
0.013787217,
0.021143552,
0.0012243671,
-0.017563334,
0.021940658,
0.03623451,
-0.0075860093,
0.007944032,
0.002946925,
0.0032053085,
-0.0027814242,
-0.03261376,
-0.018536072,
-0.03515369,
-0.005488542,
0.0016068763,
-0.00053492177,
0.01784705,
-0.0053061536,
0.029749587,
-0.016387941,
-0.009916529,
-0.005951268,
0.0014920391,
0.015090957,
-0.015469245,
-0.0072414977,
-0.008187216,
-0.017644396,
0.0097949365,
-0.0061133914,
-0.01582051,
-0.022291925,
0.0011103742,
0.028776849,
0.019576363,
0.021062491,
-0.015023406,
-0.016131246,
-0.02993873,
0.026128838,
0.0037659842,
-0.015617858,
-0.010558266,
-0.017955132,
-0.054419316,
0.017657906,
0.01679325,
0.020859838,
-0.008295298,
-0.021130042,
0.01314548,
0.034343075,
-0.000037654565,
0.032262493,
-0.0041679144,
0.0049819076,
-0.030884448,
0.024858873,
-0.019400729,
0.025277691,
-0.012395661,
-0.030776367,
0.010369122,
-0.032910988,
0.0017529558,
-0.013766952,
-0.015347652,
-0.0031141143,
-0.008781667,
-0.0067179753,
0.018333418,
0.025142588,
0.008470931,
0.02468324,
0.004927866,
-0.016347412,
-0.033208214,
0.008470931,
-0.02676382,
-0.046988674,
0.0049346215,
0.0056337775,
-0.027290719,
-0.007930521,
-0.0038031375,
-0.0050663464,
-0.012199762,
0.013186011,
0.003627504,
0.014982875,
0.0035835956,
-0.014550547,
-0.0030060322,
-0.021170573,
-0.031965267,
0.076954424,
0.018617135,
-0.0026800972,
-0.026088307,
0.010504225,
0.005015683,
-0.0089573,
-0.009045118,
-0.006525454,
0.008761402,
-0.02999277,
-0.009234261,
-0.016644636,
-0.00052310026,
-0.0009085648,
0.014523527,
-0.030830408,
0.0335865,
0.0130846845,
0.018265868,
-0.01185525,
0.00060120644,
-0.01525308,
-0.006650424,
0.0031512675,
-0.02466973,
0.003053318,
-0.0075454786,
-0.025331732,
-0.0023811827,
0.0003132691,
0.017198557,
-0.006636914,
-0.014955855,
0.0055054296,
0.0037254535,
-0.00059698446,
-0.013111705,
-0.002325453,
0.0010825094,
0.016901331,
0.009923284,
-0.015009896,
-0.002458867,
-0.0032036197,
0.02681786,
0.018576603,
-0.020089753,
-0.0024301575,
-0.027223168,
-0.020400489,
-0.006613271,
-0.007727867,
0.019522322,
-0.02522365,
-0.0035599528,
-0.017171538,
0.009335588,
0.0011804587,
-0.022940416,
0.01792811,
0.025453325,
0.001189747,
-0.012267314,
-0.00969361,
-0.17152622,
0.0071266606,
0.014280342,
-0.00020392044,
0.00919373,
-0.0013738243,
0.02314307,
0.0012201451,
0.004596865,
0.0010470449,
0.023778053,
0.0013738243,
-0.030722326,
-0.0087006055,
-0.025372263,
0.010828471,
-0.0152801005,
0.019981671,
0.0064376374,
-0.012510498,
0.045529567,
-0.019319668,
-0.0021987944,
-0.029101094,
-0.00022882999,
0.0038808214,
0.004262486,
-0.00788999,
-0.00075024145,
-0.01311846,
0.001209168,
-0.00970712,
0.05131196,
-0.010375878,
0.026439574,
-0.014591077,
0.011571535,
0.010497469,
0.011943067,
0.023507848,
0.0043165274,
0.032316536,
0.024399525,
-0.009396384,
-0.02049506,
0.01415875,
0.010436674,
0.0031597114,
0.008606033,
0.0070185787,
0.006782149,
-0.009761161,
0.021832576,
0.008173706,
0.029101094,
0.008376359,
0.010814961,
0.0074779275,
-0.011720148,
-0.028047293,
-0.024331974,
-0.0034856463,
0.039314847,
-0.011105431,
0.01950881,
-0.024791323,
-0.0071671912,
-0.021846086,
-0.024250912,
0.023467317,
-0.034991566,
-0.0050123055,
-0.0005762969,
-0.01840097,
0.030208936,
0.027777089,
-0.0016034987,
0.010882512,
0.005262245,
-0.010598796,
-0.041287348,
0.0045765997,
-0.024440056,
-0.009031607,
0.00056363107,
-0.0005674308,
0.008275033,
0.015631368,
0.016198799,
-0.01841448,
-0.009963815,
-0.024966955,
0.021319186,
-0.020251876,
0.040476732,
0.025466835,
-0.014442465,
0.018738726,
-0.012442946,
0.02096792,
0.009916529,
-0.0031360683,
-0.020670693,
0.0019724974,
0.03199229,
-0.009585528,
-0.014415445,
0.016901331,
0.053689763,
-0.026925942,
0.007356335,
-0.019360198,
0.0011829919,
0.023507848,
-0.01568541,
0.0057249716,
-0.02048155,
0.0048332945,
0.04039567,
-0.017995663,
0.06879423,
-0.0152801005,
-0.009031607,
-0.0021278656,
0.00998408,
-0.014793731,
-0.12180848,
-0.029830648,
-0.006201208,
0.0076400503,
-0.013152235,
0.012652356,
-0.00019262671,
0.035640057,
0.010848736,
0.018833298,
-0.01340893,
-0.0036646572,
0.0087478915,
0.0013518701,
-0.01130133,
-0.0066234036,
0.02412932,
0.0064680357,
-0.03407287,
0.031127632,
-0.005714839,
0.008795178,
0.0032525945,
0.0031614,
0.0053264187,
-0.0060120644,
-0.030100852,
0.031749103,
0.0011931246,
0.012145721,
0.0057215937,
-0.0053129084,
0.01840097,
0.012861765,
0.0010563332,
0.002457178,
0.028965991,
-0.0008899882,
0.028668765,
-0.025696509,
0.009653078,
0.004813029,
0.015469245,
-0.011747168,
0.012557784,
-0.015509775,
-0.003853801,
0.021846086,
0.016050186,
-0.010342102,
-0.026007244,
-0.010828471,
-0.050501343,
0.005839809,
0.014442465,
-0.020427508,
-0.011145962,
0.029074073,
-0.0075792545,
-0.013820993,
-0.016577085,
0.00035126667,
-0.009808446,
0.0049582645,
0.028155375,
-0.006224851,
0.005883717,
-0.048096515,
0.028614724,
-0.036558755,
-0.007356335,
0.0113418605,
-0.0040193014,
-0.0029215931,
-0.015374673,
0.017252598,
-0.006761884,
-0.0041037407,
-0.00092123065,
-0.022818824,
-0.010423164,
-0.013091439,
0.03731533,
-0.00012771416,
0.006761884,
0.026642228,
0.0020957787,
0.0019336556,
-0.0100921625,
-0.019062974,
-0.009680099,
0.04036865,
0.010402898,
-0.0056641754,
-0.03369458,
0.02048155,
-0.009504466,
-0.008653319,
0.03685598,
0.020832816,
-0.03993632,
-0.023494337,
-0.058040064,
0.02780411,
0.013260317,
-0.002256213,
0.0036950554,
0.0012269003,
-0.00066791335,
-0.017441742,
-0.00044077213,
0.020684203,
-0.013530523,
0.00870736,
0.0014650185,
-0.013489991,
-0.022008209,
-0.005194694,
0.032100372,
-0.008295298,
0.008220991,
0.021656942,
0.0077008465,
0.015509775,
0.0089978315,
0.01944126,
-0.009173465,
-0.0038774437,
-0.013517012,
0.03364054,
-0.022129802,
-0.01994114,
0.00471508,
-0.02947938,
-0.01569892,
0.018900849,
-0.00006765684,
-0.005400725,
0.007842705,
0.023089029,
0.026952963,
0.032992046,
-0.005941136,
-0.04296262,
0.0068226797,
0.009295057,
-0.0069104964,
-0.0060965037,
-0.032478657,
0.0037153207,
0.0053500617,
-0.0055932463,
0.024615688,
0.004894091,
-0.019562852,
-0.008862728,
-0.030398078,
0.009842223,
0.015347652,
-0.008268277,
-0.014307362,
-0.007504948,
0.026372023,
-0.0021852842,
0.023264663,
0.009930039,
-0.002644633,
-0.0152801005,
-0.009781426,
0.015334142,
-0.00043000616,
-0.03150592,
-0.022832334,
0.022345966,
0.017806519,
0.016968884,
0.00024107365,
0.0064173723,
-0.021089511,
-0.007565744,
-0.008322318,
0.018063214,
-0.00013457483,
-0.011395902,
-0.01894138,
-0.0016406518,
0.012057904,
0.003890954,
-0.012294334,
0.031424858,
0.0056405324,
-0.004171292,
-0.01680676,
0.022643192,
0.0011306397,
0.006680822,
-0.0036781675,
0.0077481326,
0.006829435,
-0.012996867,
0.010673103,
0.02203523,
-0.010700123,
-0.003163089,
0.006964538,
-0.029830648,
-0.0133684,
0.012132211,
-0.03574814,
-0.026844881,
-0.011281065,
0.0067112204,
0.032262493,
0.0057992777,
-0.018009173,
0.0014802176,
-0.011193248,
-0.008822198,
0.008585769,
0.0067720166,
-0.008646565,
0.034991566,
0.006241739,
0.030533182,
0.019265627,
0.006805792,
-0.018617135,
0.024223892,
0.01727962,
-0.023751032,
0.026777329,
-0.0031917982,
0.0026716534,
0.010706879,
-0.04512426,
0.009821957,
-0.00062822696,
-0.0035633303,
0.006481546,
0.008369604,
0.00074095314,
0.089708105,
0.0044077216,
-0.00256526,
-0.018995421,
-0.0042827516,
0.013091439,
-0.0017512671,
0.018306399,
-0.0006738241,
-0.018563094,
0.010538001,
-0.021562371,
0.019306157,
-0.03531581,
-0.03723427,
-0.0031124256,
-0.009781426,
0.0070050685,
0.0022866111,
-0.02257564,
-0.0024065145,
-0.005448011,
0.00085832353,
0.0032914365,
-0.021454288,
0.00091278675,
0.04839374,
-0.0011390835,
0.010619062,
-0.022345966,
-0.0072752736,
-0.008004827,
-0.0326678,
-0.007741377,
0.00049987953,
-0.034018826,
0.00013489148,
-0.00434017,
0.012287579,
0.0064072395,
-0.007673826,
0.018725216,
-0.005873584,
-0.0124902325,
0.009605793,
-0.014064178,
-0.010179979,
-0.025547896,
-0.029452361
] |
The murine monoclonal antibody (MAb) 18B7 [immunoglobulin G1(kappa)] is in preclinical development for treatment of Cryptococcus neoformans infections. In anticipation of its use in humans, we defined the serological and biological properties of MAb 18B7 in detail. Structural comparison to the related protective MAb 2H1 revealed conservation of the antigen binding site despite several amino acid differences. MAb 18B7 was shown by immunofluorescence and agglutination studies to bind to all four serotypes of C. neoformans, opson | [
-0.012856764,
-0.022066593,
-0.004819635,
-0.012850157,
-0.0038319235,
-0.0001012177,
-0.011799682,
-0.007610993,
-0.02650634,
0.011878963,
0.005688424,
-0.000786205,
-0.005305232,
-0.013101215,
-0.03036469,
0.0066464054,
0.032848835,
0.00008790094,
-0.034645874,
0.008509513,
-0.022885833,
0.007947938,
-0.0076836674,
-0.02938689,
-0.029492598,
0.0030655388,
0.013847779,
-0.04727801,
-0.019926002,
0.015671246,
0.00057726604,
-0.010511363,
-0.030655388,
0.0058469865,
-0.004984804,
-0.02493393,
0.027219871,
-0.002171974,
0.011495771,
0.014904861,
-0.0000894494,
0.0078091957,
0.012949259,
-0.010663318,
-0.00033116408,
0.009216437,
-0.009394819,
-0.02111522,
-0.018155389,
0.01166094,
-0.016490484,
0.01080206,
-0.007551532,
0.010432081,
-0.023612577,
-0.011601479,
0.019503169,
0.017613634,
-0.007300475,
-0.026347777,
-0.0119846715,
-0.01707188,
-0.009513741,
-0.0029003697,
0.016107293,
-0.0025848967,
-0.01849894,
0.0057247616,
-0.017811837,
-0.002764931,
0.031659618,
0.03353594,
-0.0055430755,
-0.013596722,
0.029175473,
-0.00792151,
-0.02560782,
0.012440538,
0.0030308533,
0.005780919,
0.028541224,
-0.018406447,
-0.01010835,
0.016503697,
0.011059724,
0.012770876,
0.011627906,
-0.011799682,
0.00033116408,
-0.0012874933,
0.008271669,
0.023242598,
0.0135438675,
0.013358878,
-0.041464053,
0.014495241,
0.0013932015,
0.03686575,
-0.0015154267,
-0.013715643,
-0.007241014,
0.0063887415,
-0.009559988,
-0.021987313,
-0.02830338,
-0.0091371555,
0.000004055031,
-0.01076242,
0.009612842,
-0.0004905523,
0.0055595925,
0.029519025,
-0.008562367,
-0.023084035,
0.015301267,
0.01237447,
0.03646934,
-0.02340116,
0.027272724,
-0.011799682,
0.0026080203,
0.0014691793,
0.016371563,
-0.02328224,
0.031527482,
0.02133985,
-0.035544395,
-0.049022194,
-0.015591964,
-0.0062764264,
0.018657504,
0.025528539,
0.01639799,
-0.0016351743,
-0.010359407,
0.02489429,
-0.032848835,
-0.0018432874,
-0.007577959,
-0.03179175,
0.013623149,
0.03604651,
0.012539639,
0.0052755014,
0.010359407,
0.0027897065,
0.017851477,
0.022304438,
0.0045289374,
-0.0046874997,
-0.015975157,
-0.029360462,
0.016701901,
0.002208311,
0.020177059,
-0.011832716,
-0.0006829743,
0.0304704,
-0.033562366,
0.0061310777,
-0.026030652,
-0.0057379752,
0.0049815006,
0.017811837,
0.0119846715,
0.032584563,
-0.0008828289,
-0.009612842,
-0.003871564,
-0.0072476207,
-0.0053085354,
0.025462471,
-0.026664902,
0.01688689,
-0.012037525,
0.015763741,
0.0051697935,
-0.0021934458,
-0.02358615,
-0.019608878,
0.002432941,
0.019212471,
-0.0075977794,
0.0015112974,
-0.0027335489,
0.012546246,
0.027272724,
-0.004855972,
0.002824392,
-0.018961415,
-0.006904069,
0.022225156,
0.026942385,
-0.0054571875,
-0.63720924,
-0.023916489,
0.033985198,
-0.004984804,
-0.0059758187,
0.016080866,
0.023757925,
-0.007822409,
-0.0047205333,
0.021868391,
0.008938952,
-0.0038088,
0.0046511623,
-0.032663845,
-0.011330602,
-0.03440803,
-0.008080073,
-0.02714059,
0.02115486,
-0.0039442386,
-0.020956658,
0.003149775,
-0.005503435,
0.006669529,
-0.001443578,
-0.0121894805,
0.021868391,
-0.02946617,
-0.0045289374,
0.02848837,
-0.027536996,
0.049630016,
0.02609672,
-0.0016302192,
0.04223044,
-0.016741542,
-0.012453752,
0.01012817,
0.0065274835,
0.0381871,
0.0051433663,
-0.012850157,
0.006818181,
-0.012301796,
-0.038847774,
0.04188689,
0.010887948,
0.027906975,
0.003374405,
-0.009156976,
-0.008410411,
0.013847779,
-0.018816065,
-0.00087291875,
0.02538319,
-0.0006032802,
0.033747353,
-0.028039109,
0.019899575,
-0.0015063423,
0.0072013736,
0.014772725,
-0.019714586,
-0.04466173,
-0.046749465,
-0.0043637683,
-0.019186044,
-0.0106963515,
0.0136099355,
-0.018300738,
0.027457714,
0.015327694,
0.0044628694,
0.009289111,
0.017045453,
0.033377375,
0.00030453055,
-0.016226213,
0.00013203206,
-0.0073797563,
0.010022462,
-0.0039409352,
-0.024828222,
0.023982557,
0.027431287,
-0.0046181283,
-0.01594873,
0.020282768,
0.008509513,
0.0064250785,
0.008522727,
0.0028227402,
0.0000060486736,
-0.03134249,
-0.013107821,
0.025343549,
0.0016946351,
0.0127312355,
0.013180495,
-0.0078488365,
-0.010835094,
0.003749339,
0.00014689728,
-0.013213529,
0.02687632,
0.0075911726,
-0.03387949,
0.026083507,
0.04080338,
-0.02426004,
-0.0057941326,
-0.000663154,
-0.0018251188,
-0.008641648,
0.03961416,
-0.023559723,
0.001181785,
-0.0014683534,
0.0058965376,
-0.045507394,
0.024669658,
-0.00402352,
0.015327694,
0.0074260035,
-0.004310914,
-0.0060517965,
0.008212209,
-0.025409617,
0.0048691854,
-0.03155391,
0.028884776,
0.003679968,
-0.0032686968,
-0.012605707,
0.055285405,
0.0152748395,
0.027510568,
0.007584566,
-0.0037328221,
-0.01703224,
-0.037684985,
-0.01235465,
-0.009467494,
0.013121035,
-0.0117468275,
-0.001732624,
-0.017785411,
0.00471723,
-0.0114759505,
0.014719872,
0.01257928,
0.017098308,
-0.0074260035,
0.010788847,
0.024458243,
-0.017811837,
-0.017877905,
-0.021075578,
0.004905523,
-0.005087209,
0.0051466697,
0.00073169917,
-0.018406447,
-0.005797436,
-0.010709565,
0.0010785543,
0.017917546,
0.019820293,
-0.012030918,
-0.031738896,
-0.030443972,
-0.031210355,
-0.015631605,
0.010993657,
0.017811837,
0.010451902,
-0.012718022,
-0.0049583768,
-0.0117798615,
-0.00471723,
-0.005107029,
0.0017590511,
-0.0057313684,
0.00068090967,
0.050449256,
-0.010841701,
0.03134249,
0.0031051794,
0.021881605,
0.022225156,
-0.006884249,
0.020309195,
-0.007022991,
0.03010042,
-0.008687896,
-0.006540697,
0.010828488,
0.010273519,
0.024669658,
0.03934989,
0.016582979,
-0.020163845,
0.004383588,
-0.018697144,
0.010636891,
-0.03313953,
0.006616675,
-0.020243127,
0.040988367,
-0.0019423888,
0.0037394287,
0.003775766,
0.0064581125,
-0.022846192,
0.006937103,
-0.010960623,
-0.02478858,
0.0077034878,
-0.014138476,
-0.0154069755,
-0.012638741,
0.03395877,
0.027721984,
0.009672304,
-0.016292281,
0.0112050725,
0.021868391,
0.0054340637,
0.0072608343,
-0.008866278,
-0.013464587,
-0.004525634,
0.012004491,
0.00096706516,
0.0033198993,
-0.014059195,
0.022304438,
-0.013088001,
0.034962997,
-0.015750527,
-0.01625264,
0.0112050725,
0.018789638,
0.016754756,
0.03882135,
-0.009797832,
-0.006603461,
0.031183928,
0.017190801,
0.026440272,
-0.027589848,
-0.014098836,
-0.006989957,
-0.013887419,
0.003352933,
0.0055595925,
-0.006937103,
0.014534882,
0.01980708,
0.019371035,
0.018948201,
0.0075052846,
-0.0064515057,
-0.01255946,
0.026294922,
0.0143234655,
-0.004915433,
-0.017943973,
-0.0045751845,
0.0019820293,
-0.013794924,
-0.0031382132,
0.010042282,
-0.026268497,
-0.0067091696,
0.0033925737,
0.007577959,
-0.001021571,
0.027167017,
0.017996827,
-0.027589848,
-0.031580336,
0.009738371,
0.020877376,
-0.0026873015,
-0.009632663,
-0.002294199,
-0.018578222,
-0.025991011,
0.015578751,
0.00050294,
0.0119846715,
0.00053349626,
0.0114429165,
-0.01756078,
-0.033932343,
0.02856765,
-0.021736255,
-0.009996035,
0.0036766645,
-0.016490484,
-0.005572806,
-0.012044132,
-0.025237842,
0.01793076,
0.00448269,
-0.021260569,
-0.002690605,
-0.014772725,
-0.004423229,
-0.0011322343,
0.011396669,
-0.005609143,
-0.018155389,
-0.011072937,
0.024801794,
-0.005001321,
-0.00402352,
0.010167811,
-0.001117369,
-0.0075052846,
-0.0279334,
0.011978065,
-0.014759513,
0.019833507,
0.010412261,
0.0074590375,
0.010920982,
0.02272727,
0.026453486,
-0.007439217,
-0.02227801,
0.026149575,
0.012949259,
-0.019397462,
-0.001668208,
0.013206922,
-0.009540169,
0.0045850947,
0.016715115,
-0.0063788313,
-0.017785411,
0.006672832,
0.030681815,
0.025251055,
0.0006755417,
0.0026988634,
0.032875262,
0.01055761,
0.0055001318,
0.013471193,
0.013193709,
-0.004571881,
-0.035993654,
0.015658032,
-0.0047535673,
0.0109341955,
0.0065539107,
-0.007696881,
-0.025396403,
-0.0041160146,
0.014283825,
-0.0019638608,
0.0068313945,
0.041014794,
0.027721984,
-0.013755284,
0.01819503,
0.0033298093,
-0.0006160808,
-0.0076176,
0.008522727,
-0.004198599,
-0.026228856,
0.01931818,
-0.020177059,
-0.021260569,
-0.012381077,
0.0046181283,
0.0076704537,
-0.0055364687,
0.001427887,
-0.01733615,
-0.0184593,
-0.0005124372,
-0.060517963,
0.006619978,
0.0046610725,
-0.012949259,
-0.021207714,
-0.034751583,
-0.005952695,
-0.011931817,
-0.014548096,
0.0112050725,
-0.025264269,
-0.003128303,
0.0040400364,
0.004525634,
0.048308663,
0.022159088,
-0.028620504,
0.016279068,
0.017217228,
-0.014574523,
0.014667017,
0.0069965636,
-0.022793338,
0.0346723,
0.010689746,
0.054334033,
-0.042758983,
-0.03488372,
0.011931817,
0.011383455,
0.0009183403,
-0.012037525,
0.014772725,
-0.014904861,
0.008417018,
0.0085954005,
0.016041225,
-0.0080866795,
-0.020996299,
0.0012924484,
-0.0152352,
-0.005503435,
-0.027616275,
0.005523255,
0.015155918,
-0.011826109,
-0.0029003697,
-0.023414373,
0.013094608,
-0.015433402,
-0.017455073,
-0.0054208506,
0.007300475,
0.0194371,
0.0033347644,
-0.010445295,
0.006266516,
0.028461942,
-0.027167017,
-0.00013781298,
0.0040895874,
0.018763212,
0.009969608,
-0.030126847,
0.029334035,
-0.009553381,
-0.0077695553,
0.0074193967,
-0.0145613095,
-0.015605178,
0.02740486,
-0.0030358084,
-0.0136099355,
-0.037526425,
-0.014719872,
-0.01609408,
0.00741279,
0.011753434,
-0.014402747,
-0.021273782,
-0.0037196085,
0.004096194,
-0.0038088,
-0.012248942,
-0.026717756,
-0.028673358,
0.03699788,
0.0018152086,
0.01304836,
-0.012328222,
0.0117468275,
-0.013689216,
0.0018498941,
-0.010484936,
-0.029175473,
0.008483086,
0.00382862,
0.039297037,
0.008443445,
0.02991543,
-0.0021372885,
0.024180759,
0.03845137,
0.012262155,
0.012704808,
-0.005367996,
0.023995768,
-0.033113103,
0.004241543,
0.014891648,
-0.009632663,
0.015750527,
-0.008099893,
0.021405917,
0.0013948532,
-0.024867862,
-0.02354651,
-0.008165961,
-0.015882662,
-0.024590379,
0.018049682,
-0.021908032,
0.0074656443,
-0.044767436,
-0.008866278,
0.022899047,
-0.0043307343,
0.008654862,
0.003374405,
0.020137418,
-0.032478854,
-0.0030176397,
-0.0045983084,
-0.012836943,
0.0047568707,
-0.0007659718,
0.012552853,
-0.014336679,
0.024405388,
0.011892176,
-0.0073467223,
0.020005284,
-0.024656445,
0.0109672295,
0.0027087736,
-0.0043637683,
-0.00652418,
-0.006283033,
-0.029756868,
-0.023123676,
-0.021881605,
-0.02272727,
-0.032822408,
0.015393762,
0.008245242,
-0.014415961,
0.010795454,
0.009493921,
-0.036971454,
0.026955599,
-0.0062698196,
0.029519025,
-0.017507926,
0.014415961,
0.016530124,
0.009857293,
-0.033218812,
-0.0058007394,
-0.0066397986,
0.0042019025,
0.018432874,
0.03488372,
-0.0073731495,
-0.006695956,
0.020031711,
0.030153275,
-0.010795454,
-0.031501055,
0.027272724,
0.009071087,
0.007194767,
-0.010498149,
-0.024643233,
-0.02714059,
0.0154069755,
-0.025092492,
-0.009196617,
-0.009896933,
-0.019556023,
-0.026651688,
0.013676003,
0.006226876,
0.021022726,
0.0034619446,
-0.017613634,
0.0059229643,
-0.02838266,
0.0065010563,
-0.00857558,
-0.013398519,
0.044344604,
-0.0021224231,
-0.005866807,
0.004406712,
0.0030688422,
-0.013979914,
0.0022529068,
-0.011819502,
0.028409088,
0.00022752046,
-0.0014361455,
0.008555761,
-0.0043571615,
0.013167282,
0.0005995639,
-0.0074193967,
0.005358086,
-0.009969608,
-0.0038121033,
0.020969871,
0.012585887,
-0.011945031,
0.006530787,
-0.02062632,
-0.0063325837,
-0.029730441,
-0.03168604,
0.0061376845,
-0.03290169,
-0.0010777285,
-0.011997884,
-0.0065605175,
0.033086676,
-0.0067851474,
-0.0027781446,
0.014402747,
0.020335622,
-0.020547038,
0.000044027893,
0.02452431,
0.000010129512,
-0.018472513,
-0.0055529857,
0.0030952692,
-0.014310252,
0.0121102,
-0.015327694,
-0.040644817,
-0.020560252,
-0.019978857,
0.017547566,
0.01331263,
-0.027510568,
0.025753168,
0.0012205997,
0.017243655,
-0.0013040102,
-0.0058635036,
0.010465115,
-0.010610464,
-0.0094080325,
0.010009249,
-0.014349893,
-0.016146934,
-0.010101743,
-0.011376848,
-0.008291489,
-0.049207184,
-0.021022726,
-0.010755813,
0.0060418863,
-0.0046709827,
-0.013570295,
-0.006471326,
-0.0152352,
-0.023427587,
0.0065506073,
-0.003326506,
0.0008828289,
-0.024418602,
-0.011079544,
-0.00201176,
0.0044926,
-0.01302854,
-0.00718816,
0.0022677719,
-0.029334035,
-0.02856765,
-0.0016599497,
-0.011522197,
0.044688158,
-0.0032224494,
-0.0073863626,
-0.011198466,
0.0004509117,
-0.043419655,
0.007630813,
-0.007194767,
0.010874734,
0.007743128,
0.02875264,
0.0042019025,
0.0135438675,
-0.0016351743,
0.01464059,
0.004007003,
0.0020068048,
0.012790697,
-0.025541753,
0.028884776,
0.0020662656,
-0.023189744,
-0.007485464,
0.027087735,
0.005242468,
-0.010722779,
0.03639006,
-0.029862577,
0.010062102,
-0.006438292,
0.014297038,
-0.006428382,
0.014244185,
0.011172039,
-0.008093286,
-0.032214586,
-0.012982292,
-0.010722779,
0.008846458,
-0.013187102,
0.025475685,
0.011878963,
0.027880548,
-0.021868391,
-0.008185782,
0.0035709562,
-0.013583508,
0.025079278,
0.023982557,
0.005995639,
0.0069106757,
0.0005541424,
-0.00806686,
-0.008714323,
0.0074590375,
0.009388212,
-0.020533824,
0.014482028,
-0.007663847,
0.01744186,
-0.011172039,
0.004664376,
-0.014614163,
-0.0035874732,
-0.01811575,
-0.015129491,
-0.008674682,
0.007994185,
0.010181025,
-0.015155918,
-0.0053547826,
-0.0098837195,
0.011753434,
-0.008773783,
0.006798361,
-0.0071683396,
0.0060286727,
-0.007267441,
0.017349364,
-0.012691595,
-0.0018465907,
0.015155918,
-0.0007750561,
0.0036997881,
-0.0071220924,
0.18678644,
-0.010432081,
0.00971855,
-0.008826638,
-0.010035676,
-0.03406448,
-0.0010314811,
-0.00030143364,
0.00090843014,
0.012096986,
0.017375791,
-0.007108879,
-0.015023783,
0.005282108,
0.0035412258,
0.013715643,
-0.025528539,
-0.020309195,
-0.01849894,
-0.019463528,
-0.004367071,
0.0077100946,
0.019304967,
0.013266384,
-0.0050409613,
0.0010091834,
-0.023797566,
0.015327694,
0.009784618,
0.018512154,
-0.026043866,
0.004010306,
-0.010689746,
-0.0056058397,
-0.010478329,
-0.017389005,
-0.014719872,
-0.019648518,
-0.010002642,
0.022951901,
-0.01733615,
-0.001492303,
-0.0039079012,
0.02542283,
0.0092032235,
0.017666489,
0.0019291752,
-0.018155389,
0.0014815669,
-0.004165565,
-0.02938689,
0.0064812363,
0.011502378,
0.015790168,
0.0040036994,
-0.024286468,
0.023731498,
-0.0035280124,
-0.024563951,
0.018974628,
-0.0109672295,
-0.007967758,
-0.01801004,
0.040935513,
0.010709565,
0.05866807,
-0.008747356,
0.016569765,
0.01190539,
-0.004813028,
0.0092032235,
0.00876057,
-0.02489429,
0.0076770606,
0.00019520924,
-0.019159617,
0.037024308,
0.024801794,
0.01662262,
0.015354121,
-0.004945163,
0.016860463,
-0.009830866,
0.0015096457,
-0.030761097,
-0.019384248,
-0.008654862,
0.01838002,
-0.0012395942,
0.015710887,
0.016305495,
0.0032125392,
-0.006679439,
0.009811046,
0.005364693,
0.0027104253,
0.0078818705,
0.0073335087,
0.012684988,
-0.009764798,
-0.02205338,
0.05623678,
0.009976215,
0.024141118,
-0.024418602,
0.009890326,
-0.025739955,
-0.001668208,
-0.010471722,
0.00269556,
0.017758984,
-0.030179702,
-0.011819502,
-0.017983614,
0.009870507,
0.033905916,
0.01349762,
0.004680893,
0.014904861,
-0.010874734,
-0.0007899213,
-0.031950314,
0.012539639,
0.029149046,
-0.02103594,
-0.0068908557,
-0.02036205,
0.011191859,
0.01100687,
-0.037579276,
-0.010194238,
-0.013900633,
0.016477272,
0.0099167535,
0.002523784,
0.01909355,
0.0040763738,
-0.02011099,
-0.023929702,
0.028673358,
-0.010379227,
-0.025885304,
0.009163583,
-0.002647661,
-0.0051037255,
-0.039297037,
0.008139534,
0.027114162,
-0.0024164242,
-0.0027021668,
-0.014693445,
-0.024669658,
-0.017177587,
-0.027114162,
0.022938687,
0.00013502575,
-0.009751584,
-0.027219871,
0.008859672,
-0.002203356,
-0.04196617,
-0.0019622091,
0.021841964,
-0.005916358,
0.015961943,
0.0028855044,
-0.16659617,
-0.0033826635,
0.00924947,
-0.0024577165,
0.013266384,
-0.00019407371,
-0.005771009,
-0.024563951,
-0.017111521,
0.004525634,
0.024471456,
-0.0078488365,
-0.03771141,
-0.015327694,
-0.014415961,
-0.0073665427,
-0.002652616,
0.02205338,
0.02560782,
0.0040664636,
0.041384775,
-0.02785412,
-0.015169132,
-0.017270083,
-0.013206922,
0.021141646,
-0.006428382,
0.03718287,
0.0037394287,
-0.017587207,
-0.030602533,
-0.00922965,
0.041094076,
0.0026806947,
0.02848837,
-0.005609143,
0.0035610462,
0.0016995902,
-0.011575052,
0.01860465,
0.0211945,
0.017877905,
-0.00025332812,
-0.014045982,
-0.019040696,
0.022476213,
0.030866804,
0.006197145,
0.030919658,
0.007108879,
0.017838264,
-0.0035114954,
0.033641644,
0.0069172825,
0.025277482,
0.014164903,
0.03549154,
0.028858349,
-0.009282504,
-0.0027038185,
0.0050839055,
-0.031183928,
0.019767439,
-0.023969343,
0.004595005,
-0.035068706,
-0.020031711,
0.016279068,
-0.014627377,
-0.00047816458,
-0.022515854,
0.005701638,
0.012447145,
-0.020586679,
0.010227271,
0.025924945,
-0.0099167535,
0.0044926,
0.013054967,
0.010214058,
0.0003924831,
0.018261097,
-0.026704542,
0.011508984,
-0.0034024839,
-0.009011627,
-0.0029647856,
-0.0040367334,
0.009976215,
0.019476742,
0.012083773,
-0.024867862,
0.022991542,
-0.034090906,
0.036072936,
0.0044430494,
-0.020639533,
-0.010114957,
0.00335954,
-0.0023090641,
0.0086614685,
-0.017190801,
-0.024603592,
0.0024940537,
0.039772723,
-0.017732557,
0.007359936,
0.0044430494,
0.0391649,
-0.011793075,
-0.008304703,
0.0025056156,
0.022700842,
0.035676528,
-0.00924947,
0.0068380013,
-0.010141384,
-0.009744978,
-0.0054340637,
-0.022026954,
0.06649048,
0.006316067,
-0.002198401,
0.00078703085,
-0.021260569,
-0.00027521304,
-0.11522198,
-0.029704014,
0.0015575448,
-0.0068247877,
-0.026612047,
0.008165961,
0.011350421,
0.025991011,
-0.010894555,
0.014389534,
-0.01995243,
-0.006570427,
0.0023966038,
-0.0016805958,
0.0070295976,
0.016107293,
0.013365485,
0.0039012944,
-0.005328356,
0.027510568,
0.0015443312,
0.017640062,
-0.012447145,
-0.014838793,
0.0033182476,
-0.0074524307,
-0.007941331,
0.020044925,
0.016213,
0.027378432,
0.016569765,
-0.024775367,
0.010339587,
0.01505021,
-0.010326373,
0.011588265,
-0.020864163,
-0.021458771,
0.041569762,
-0.002117468,
-0.011760041,
0.0042910934,
-0.009778012,
0.0017557477,
0.023295453,
0.016794397,
-0.0070428113,
0.0028574257,
0.006150898,
-0.025277482,
-0.026704542,
-0.02111522,
-0.026704542,
-0.0152748395,
0.035544395,
-0.012737842,
-0.012176267,
0.015089851,
-0.018789638,
-0.0008093287,
0.0065175733,
-0.006325977,
-0.025581393,
-0.020824522,
0.013728857,
0.007829016,
-0.019344607,
-0.016213,
0.0009984473,
-0.025528539,
-0.011383455,
-0.0049914108,
-0.015631605,
-0.014442388,
-0.01917283,
0.0036304172,
-0.013557081,
-0.035280123,
0.007062631,
0.004829545,
-0.027563423,
-0.010484936,
0.021181287,
-0.009011627,
0.04751585,
0.023493655,
0.019912789,
-0.0053349626,
0.017996827,
-0.010683139,
0.0012974034,
0.033483084,
-0.003230708,
-0.024061836,
-0.01931818,
0.014904861,
-0.017772198,
-0.0060584033,
0.009797832,
0.031923886,
-0.018181816,
-0.0000041389058,
-0.072621554,
0.030655388,
0.0057247616,
-0.0005611621,
0.011911997,
-0.018591436,
0.015446615,
-0.007326902,
-0.0018317255,
0.013821351,
-0.016384777,
0.009540169,
-0.024167545,
0.018102536,
-0.02687632,
-0.006193842,
0.02946617,
0.0040730704,
0.023057608,
0.025211414,
-0.021498412,
-0.0047535673,
0.010504756,
0.01909355,
-0.04204545,
0.004109408,
-0.042177584,
0.017547566,
-0.002016715,
0.0064250785,
0.011594872,
-0.023361519,
0.005804043,
0.029571878,
-0.010200845,
-0.007531712,
0.009877113,
0.039191328,
0.0091041215,
0.037605703,
-0.019067124,
-0.029783295,
0.012182874,
0.000877048,
-0.0063788313,
-0.01104651,
-0.018512154,
0.014772725,
0.005321749,
-0.035914373,
0.030417545,
0.016979385,
-0.008060253,
-0.059619445,
-0.025224628,
0.019489955,
-0.0053481758,
-0.0060617067,
-0.005338266,
0.007994185,
0.029122619,
0.0062334826,
-0.0062004486,
0.010154597,
0.011997884,
-0.0099828215,
-0.004139138,
0.006656315,
0.014230971,
-0.021894818,
-0.014310252,
-0.014838793,
0.0007259183,
0.0037030915,
-0.0047469605,
-0.004155655,
0.0049815006,
0.003637024,
-0.00516649,
0.028964056,
0.016186573,
-0.015248413,
0.0059758187,
0.003422304,
-0.0045289374,
-0.005282108,
0.010484936,
0.012268762,
0.0030093812,
0.0005277153,
0.0018086018,
0.021709828,
0.0017937366,
0.015089851,
-0.016503697,
0.023084035,
0.0078818705,
0.009071087,
0.0202167,
0.030840378,
0.009738371,
0.0010818577,
0.0030655388,
-0.014072409,
-0.016054438,
0.016120506,
-0.028805494,
-0.007095665,
-0.02062632,
0.014931289,
0.009797832,
0.01164112,
-0.0011900435,
0.010504756,
-0.014957715,
0.010769026,
0.0078818705,
0.0004905523,
-0.014072409,
0.051268492,
-0.0007610167,
0.023533296,
-0.011608086,
-0.022145875,
0.015420189,
0.010709565,
0.02687632,
-0.044503167,
0.024445029,
-0.00880021,
-0.0051697935,
-0.029069765,
-0.0072542275,
-0.0153409075,
-0.009447673,
-0.010920982,
0.0026162788,
-0.0012082121,
-0.0112315,
0.0963002,
0.02497357,
-0.023308666,
0.008542547,
-0.026189215,
0.0029945162,
0.021432344,
0.003219146,
0.013180495,
-0.02433932,
0.0025436045,
-0.004406712,
0.021960886,
-0.016173359,
-0.033271667,
0.00065117923,
-0.007241014,
-0.0038550473,
-0.01680761,
-0.000492204,
0.030311836,
0.0028623808,
-0.00056074915,
-0.002915235,
-0.014785939,
0.006180628,
0.011317388,
-0.036627904,
-0.013794924,
-0.01841966,
0.016873676,
0.003722912,
-0.040776953,
-0.02474894,
0.009870507,
-0.016028011,
0.0018680627,
-0.009573202,
-0.009606236,
-0.0047073197,
-0.0055199517,
0.045348834,
-0.017481498,
-0.014138476,
0.034223042,
-0.016464058,
-0.040750526,
0.004624735,
-0.0037559457
] |
Metastatic ovarian cancer is the leading cause of death among women with gynecologic malignancies in the United States. The lack of effective treatment for patients with advanced ovarian cancer warrants development of innovative therapies. Cancer therapy using oncolytic viruses represents a promising new approach for controlling tumors. Vaccinia virus has been shown to preferentially infect tumor cells but not normal tissue. However, oncolytic therapy using recombinant viruses faces the limitation of viral clearance due to generation of neutralizing antibodies. In the current study, we found that cyclooxygenase-2 (Cox-2) inhibitors circumvented this limitation, enabling repeated administration | [
-0.035619717,
-0.021339128,
-0.0049157664,
-0.01898174,
0.0009947357,
0.0005812562,
-0.02155715,
-0.024309708,
-0.015288953,
-0.003934657,
0.022470128,
0.018436678,
0.011868697,
0.0069665574,
-0.021870561,
0.004346859,
0.047393028,
-0.003539488,
0.009361418,
-0.0040130094,
-0.0022279357,
0.010710443,
-0.01133045,
-0.015765881,
0.0016683968,
0.020957584,
-0.0051065376,
-0.04014372,
0.007991953,
-0.0030540433,
-0.0123388115,
-0.0061148996,
0.0009657795,
0.0022364522,
-0.0040061963,
-0.016338196,
0.024718503,
-0.01616105,
-0.0013541352,
-0.00792382,
0.02042615,
0.003767732,
-0.003805205,
0.0066224877,
-0.006629301,
0.002609478,
-0.008918555,
-0.030823184,
-0.0013234755,
0.01643358,
0.0037370725,
0.013749156,
-0.021298246,
0.011575727,
-0.005569839,
-0.004019823,
0.0085302,
0.00072816707,
0.015765881,
-0.022183971,
-0.016951388,
-0.003387893,
-0.03752743,
0.023778273,
-0.0085302,
0.039108105,
-0.022156717,
0.012618155,
0.0078011816,
-0.0005182335,
0.03733666,
0.025399828,
-0.018886354,
0.02101209,
0.020725934,
-0.020794066,
-0.043032542,
0.009627135,
0.013026951,
0.007821621,
0.015152688,
-0.016719738,
-0.0001700121,
0.008428001,
0.0313955,
-0.006676994,
-0.0053381883,
0.0054437937,
0.008230417,
0.011453088,
0.02375102,
0.02289255,
0.018995365,
0.03283991,
-0.009960985,
0.027689084,
-0.0017867772,
0.01124869,
0.0031783853,
-0.023614755,
0.006203472,
0.006860952,
-0.026816987,
-0.024595864,
-0.027525567,
0.006656554,
-0.002321618,
0.0032175614,
0.03428432,
0.0070312833,
-0.030686919,
0.035319936,
-0.0008341984,
-0.008455254,
0.022919804,
0.006666774,
0.030986702,
0.009266032,
-0.018913606,
-0.0051133507,
0.0057742367,
-0.00090786675,
0.0109352805,
-0.015493351,
0.013258602,
-0.029842073,
-0.032976173,
-0.0065236953,
0.0097088935,
0.002207496,
0.029951086,
0.025168179,
0.013156403,
-0.009995051,
-0.015588736,
0.018450305,
-0.025876757,
-0.017987004,
-0.012590903,
-0.020875825,
-0.0041356483,
0.038644806,
-0.012781674,
0.007951073,
-0.043414086,
0.009497683,
0.020957584,
0.0011335559,
0.013967181,
0.013531133,
0.0025720051,
-0.027607325,
0.016065665,
-0.017114906,
0.00037323884,
-0.011861884,
-0.0014852905,
0.017455569,
-0.02155715,
-0.019336028,
0.0031528356,
-0.00046244994,
-0.002970581,
0.0127953,
0.012345625,
0.026421819,
0.020943958,
0.013306295,
-0.023887286,
-0.018450305,
0.00047394732,
0.03142275,
-0.015956651,
0.031231979,
-0.017891617,
0.02097121,
-0.013899048,
0.017537327,
-0.027021384,
-0.004687522,
-0.021611657,
0.0206578,
0.0008184427,
0.007991953,
-0.033466727,
0.02747106,
0.0025243124,
-0.028315904,
0.00062128407,
-0.03204957,
-0.0011148194,
0.032812655,
0.010744509,
0.0043707057,
-0.6357588,
-0.037472922,
0.0059990743,
-0.015711375,
0.0144849885,
0.019049872,
0.014076193,
-0.014444109,
-0.0015960059,
0.0075422777,
-0.025168179,
0.017714472,
-0.012236613,
-0.0144849885,
0.0011310009,
-0.031940557,
-0.0067621595,
0.004799941,
-0.002602665,
0.0061625927,
-0.017714472,
0.0063874302,
-0.009422737,
0.010083623,
0.0028564588,
0.020317137,
0.0181914,
-0.0085302,
0.0106286835,
0.030496147,
-0.015057302,
0.044776738,
-0.02946053,
-0.023492116,
0.05415178,
0.009048007,
0.0007558459,
-0.0011982819,
0.011214624,
0.03624654,
-0.022919804,
-0.008598332,
0.02249738,
-0.00581171,
-0.037500177,
0.009524936,
0.0206578,
-0.009599882,
-0.009197899,
-0.012958818,
0.014444109,
0.02621742,
-0.03984394,
-0.008761851,
0.008482507,
0.002500466,
0.019799331,
-0.03878107,
0.014062567,
-0.0003117066,
0.016733363,
0.015765881,
0.00092404825,
-0.04507652,
-0.026203794,
0.01971757,
-0.021298246,
0.018341294,
0.0034406958,
-0.0021989793,
0.017510075,
0.023369478,
0.0035701476,
-0.006796226,
0.01436235,
0.048156112,
-0.0052564293,
0.0003236298,
-0.017401064,
-0.0062545715,
0.01678787,
-0.019281523,
-0.03079593,
0.017441943,
0.024309708,
-0.01714216,
-0.031722534,
0.030414388,
0.02926976,
0.0020678241,
0.0073719462,
0.029406026,
-0.017237546,
-0.028533928,
0.0037098194,
0.009722521,
0.011984522,
0.006608861,
0.020044608,
-0.017564582,
-0.024064431,
-0.0012459747,
0.002353981,
-0.0028155793,
-0.0010211372,
0.0064487495,
-0.03428432,
-0.0042446605,
0.030032845,
-0.022211224,
-0.00790338,
-0.013292668,
0.02042615,
0.0027184903,
0.02684424,
-0.01733293,
-0.0014529275,
0.009695267,
-0.012863433,
-0.030414388,
0.021707043,
0.0016241106,
-0.0099337315,
-0.00888449,
0.0123388115,
-0.017905245,
0.014212458,
-0.014457735,
-0.025863132,
-0.009211526,
0.00040496307,
-0.035837743,
0.015452472,
-0.016147424,
0.0013873498,
-0.0040232292,
-0.004769281,
-0.0053211553,
-0.002781513,
-0.0060263276,
-0.025072793,
-0.0007268896,
0.003999383,
0.017877992,
0.0058491826,
0.0044354317,
-0.0040232292,
-0.0014324877,
-0.003367453,
0.008414375,
0.014539494,
-0.002343761,
0.020889452,
0.01663798,
0.021080224,
-0.005341595,
0.0053007156,
-0.026108408,
-0.005017965,
0.0035871807,
0.021039344,
-0.010335714,
0.012556836,
0.0051780767,
-0.005879842,
-0.016038412,
0.001039022,
0.020998463,
-0.0028104694,
-0.025931263,
-0.022483755,
-0.0213255,
0.0014333393,
0.017809859,
0.012624969,
0.011146491,
-0.0043536723,
-0.003832458,
-0.0047488413,
0.011991336,
0.015684122,
-0.030114604,
0.0005075878,
0.0074400785,
0.016842376,
0.0049327994,
0.026735228,
0.0016862815,
0.0073855724,
0.009027568,
-0.021380007,
0.03286716,
0.000549319,
0.0062409453,
0.014117072,
-0.04692973,
-0.010274394,
0.016869629,
0.03125923,
0.031013954,
0.045485318,
-0.03564697,
0.016488086,
0.00054420903,
0.018136894,
-0.0012221283,
-0.0073855724,
-0.01569775,
0.015384339,
0.013531133,
0.0071743615,
0.021134729,
-0.032267593,
0.0059070955,
-0.0016947981,
0.00395169,
0.009061635,
-0.010751323,
-0.0019383722,
-0.011119238,
-0.03660083,
-0.01252277,
0.023710141,
-0.0141306985,
-0.0036995995,
0.01308827,
-0.008128217,
0.015438844,
0.0067519397,
-0.009613508,
-0.019145258,
0.022374742,
0.0062988577,
0.018491184,
0.01569775,
0.005011152,
0.014226085,
-0.0017084247,
0.04101582,
-0.019744825,
-0.01783711,
-0.0033044305,
0.003815425,
0.012720354,
0.000745626,
0.0035531146,
0.038481288,
0.0021632097,
-0.025931263,
0.0069188643,
-0.018845474,
-0.0036382803,
0.0011139679,
0.0019826584,
0.020521536,
-0.029487785,
0.0018157335,
0.006745126,
0.05712236,
0.022674525,
0.01768722,
-0.03624654,
0.008625586,
-0.0011420725,
-0.0050043385,
0.022715405,
0.011064732,
0.016733363,
0.0009351198,
0.020412523,
-0.017673593,
-0.020276258,
0.041860662,
-0.010608244,
-0.0012442714,
0.013265415,
-0.021189235,
-0.0015449064,
0.0106763765,
0.0099337315,
-0.0341208,
-0.046357412,
0.029051736,
0.00076989824,
0.0030829997,
-0.016324569,
-0.011044293,
-0.0077466755,
0.028833712,
0.022878923,
0.028670194,
0.007140295,
-0.022838043,
0.0107581355,
-0.0016241106,
-0.011146491,
0.0032277815,
-0.01877734,
0.018177776,
0.001436746,
0.00052802754,
-0.013353988,
0.002149583,
0.002609478,
0.02078044,
0.007787555,
-0.0097634,
-0.026380938,
-0.03463861,
-0.022074958,
0.008809544,
-0.0070380964,
-0.0055664326,
-0.023410358,
-0.008720972,
0.020889452,
0.017496448,
0.0009581145,
0.013265415,
-0.005283682,
0.0071130423,
-0.014103446,
0.010567364,
-0.035156418,
0.019622186,
0.0044626845,
0.00027231744,
0.0111601185,
0.035837743,
0.011078359,
0.0027542599,
-0.014893784,
0.023096947,
-0.011105612,
-0.011173745,
0.020589668,
-0.0069086445,
0.00938867,
0.000100282654,
0.019785704,
-0.0035974006,
-0.022442875,
-0.020180874,
-0.012154854,
0.014471362,
0.00060510257,
0.040170975,
0.009879226,
0.023764648,
-0.01643358,
0.0331942,
0.024991034,
0.00082142354,
-0.006482816,
-0.008244043,
0.0053790677,
-0.0170604,
0.02954229,
-0.019404162,
-0.022102213,
0.008407561,
-0.002478323,
-0.0057061044,
0.015098182,
0.0071675484,
0.027893482,
0.008353055,
0.027852602,
0.022647273,
-0.020889452,
-0.007467332,
0.0107581355,
0.003323167,
-0.026680721,
0.046711702,
0.004643236,
-0.011534847,
-0.009974611,
-0.01584764,
0.0029024482,
-0.013817289,
0.0016726551,
-0.008121405,
0.0063669905,
-0.0090139415,
-0.01996285,
-0.006738313,
-0.006673587,
0.002371014,
-0.0057197306,
-0.020412523,
-0.012713541,
-0.004227627,
-0.01643358,
0.007971513,
-0.03327596,
-0.008768664,
0.0067008403,
0.0070994156,
0.0073855724,
0.009995051,
-0.027934361,
-0.011316823,
0.009838345,
-0.008782291,
0.0025617853,
-0.023628382,
-0.04325057,
0.0055868723,
-0.023233213,
-0.015125435,
-0.007733049,
-0.015084555,
-0.0032294847,
0.017550955,
-0.010512859,
-0.010546925,
0.0014563341,
0.012257053,
0.02429608,
0.0010645717,
0.011970896,
-0.008870863,
-0.0087073445,
0.002244969,
-0.007951073,
-0.025427083,
-0.033521235,
-0.035129163,
-0.008121405,
0.0057946765,
0.029051736,
-0.0027729964,
-0.0064862226,
0.024554985,
-0.01808239,
0.0041220216,
-0.009259219,
0.0050349985,
0.03286716,
-0.001916229,
-0.002289255,
0.027198529,
0.0022551888,
-0.0034168493,
0.022429248,
0.011357702,
-0.011126052,
-0.008666465,
0.010519672,
0.00639765,
-0.0059070955,
-0.016365448,
-0.0045274105,
0.014798398,
0.025835877,
0.0024561798,
-0.023492116,
-0.03357574,
-0.008278109,
-0.008039646,
0.0024970593,
0.017605461,
-0.03270364,
-0.00046202412,
0.0251273,
-0.00888449,
-0.046275653,
0.02078044,
-0.03431157,
0.0057742367,
0.0075082113,
-0.0071471087,
-0.00610468,
0.0007690466,
-0.00672128,
-0.021938693,
-0.004053889,
-0.025685987,
-0.010465166,
-0.015588736,
0.012441011,
0.020358017,
0.026585337,
0.037418418,
-0.028261397,
0.018423053,
0.009552189,
0.0090139415,
-0.0012945192,
-0.025072793,
0.016665231,
-0.0059718215,
0.026108408,
0.013967181,
-0.010969346,
0.0313955,
-0.016951388,
0.0048135673,
0.00397213,
-0.025904011,
-0.027729964,
-0.012958818,
-0.010594618,
-0.037500177,
0.022115838,
-0.017564582,
0.014171579,
-0.04156088,
-0.0021308467,
0.026735228,
0.01988109,
0.010887587,
-0.007262934,
0.0045342236,
0.004626203,
-0.02328772,
-0.0074060126,
0.0027781064,
-0.0061659995,
-0.010213075,
-0.002766183,
-0.005954788,
-0.008209977,
-0.0022330456,
0.0062920447,
0.0071539218,
0.0016411437,
-0.006278418,
0.037391163,
-0.0226609,
-0.012550022,
0.0072970004,
-0.038563047,
-0.02414619,
0.00013190044,
-0.016052037,
-0.023764648,
-0.021747923,
0.00245107,
-0.011187371,
0.009259219,
-0.0034270692,
-0.019199764,
0.03564697,
-0.012222987,
0.007140295,
-0.028642941,
0.040688783,
-0.0073515065,
-0.0037404792,
-0.0141306985,
-0.032376606,
-0.00454785,
-0.0008580448,
0.021148356,
0.028533928,
0.0023914538,
-0.02159803,
0.014921037,
0.0101926355,
-0.034856632,
-0.02891547,
0.031913303,
0.006895018,
0.002192166,
-0.033875525,
-0.045894112,
-0.036573574,
0.026285553,
-0.009375044,
0.014934664,
-0.0066701802,
-0.0035871807,
-0.012297932,
0.011051106,
-0.006547542,
0.007705796,
-0.0061183064,
-0.01128957,
-0.027402928,
-0.037745453,
0.014580374,
-0.00051610434,
-0.029787568,
0.022783538,
0.008782291,
-0.0006591828,
0.008714158,
0.0069086445,
0.0044081784,
-0.0005216401,
-0.0019094158,
0.040170975,
0.009981425,
0.022388369,
0.0109352805,
0.012584089,
0.0058968756,
-0.006482816,
-0.0028172825,
-0.005954788,
-0.018259535,
0.00048799967,
0.021189235,
0.020603295,
-0.012529583,
-0.012066281,
-0.012202547,
-0.003236298,
-0.03204957,
-0.020725934,
0.00079672545,
-0.024091683,
0.0042548804,
-0.02981482,
-0.0016002642,
0.018954486,
0.011541661,
0.0024578832,
0.004755655,
0.03134099,
-0.01678787,
0.0015074335,
0.0004009177,
-0.0057503907,
-0.01714216,
0.019472294,
-0.018641077,
-0.021747923,
0.0045819166,
-0.013367614,
-0.028315904,
-0.04821062,
-0.020126367,
0.015425218,
0.01710128,
-0.013170029,
0.029242508,
0.02249738,
0.003203935,
-0.024323335,
-0.025031913,
0.04643917,
0.004145868,
0.0006902683,
-0.0009921808,
-0.016174676,
-0.006656554,
0.003241408,
0.007596784,
0.00049651624,
-0.015874892,
-0.024118936,
-0.017714472,
-0.011984522,
0.030904943,
-0.0003087258,
0.009824719,
-0.009770214,
-0.020725934,
-0.006666774,
0.026939625,
-0.015248073,
-0.017932497,
-0.008761851,
-0.014893784,
-0.0123388115,
-0.034856632,
0.00077160157,
-0.008734598,
-0.009858785,
-0.028343158,
-0.014035313,
-0.025549721,
0.019145258,
0.0287247,
-0.0059241285,
-0.04066153,
-0.0063669905,
-0.036955114,
-0.0012868543,
0.012127601,
0.012529583,
0.0133880535,
0.035483453,
-0.010594618,
-0.0110306665,
-0.0069018314,
0.0031528356,
-0.0068882047,
0.005893469,
0.028234145,
-0.020494282,
0.008455254,
-0.00084739906,
-0.02602665,
0.0035871807,
0.014798398,
0.009695267,
-0.010362967,
0.0036757533,
-0.009831533,
0.008366682,
-0.021461766,
-0.016447207,
-0.00819635,
0.028969977,
0.010042744,
-0.022170344,
-0.006799632,
0.021856934,
0.0005165302,
0.01764634,
-0.015725002,
-0.013347174,
0.007078976,
0.01580676,
-0.013142777,
-0.020371644,
0.0024238168,
-0.0033912996,
0.0047284015,
0.03393003,
0.01310871,
0.008066898,
0.003442399,
-0.009266032,
-0.001188062,
-0.00395169,
-0.010478792,
-0.007882941,
0.002830909,
0.009892852,
-0.026299179,
0.0026622808,
0.017891617,
-0.011057919,
-0.007712609,
0.0102403285,
-0.007910194,
-0.024309708,
0.02935152,
0.010560552,
0.008659652,
-0.022783538,
0.018068762,
-0.0049123596,
-0.016569845,
-0.02696688,
-0.003014867,
-0.0004009177,
-0.010219889,
0.001463999,
0.004227627,
-0.0014248227,
-0.0111124255,
-0.0010654234,
-0.02383278,
0.010846708,
0.18684681,
0.008162284,
-0.0038222382,
0.01463488,
-0.02101209,
-0.0036382803,
0.030223617,
-0.022279356,
0.018286787,
0.0023096947,
0.04346859,
-0.012154854,
0.01635182,
-0.003750699,
0.014021687,
-0.0037847653,
-0.02195232,
-0.02293343,
-0.01616105,
-0.011977709,
-0.0069563375,
0.0026316212,
0.019199764,
-0.0015585329,
0.015452472,
0.005563026,
-0.025399828,
0.02809788,
0.024882022,
-0.0073787593,
-0.017578209,
0.005201923,
0.011616606,
0.010751323,
0.025754118,
0.006748533,
-0.0143078435,
-0.0213255,
-0.0035974006,
0.00366894,
0.003965317,
0.026558083,
-0.01588852,
0.003978943,
-0.01135089,
0.023042442,
0.010928467,
-0.0029910207,
-0.009586255,
-0.0000126750565,
-0.03376651,
0.0077466755,
0.009865599,
0.008945809,
-0.017632714,
0.0028905252,
0.03286716,
0.0017935904,
-0.014021687,
0.04123384,
-0.018450305,
-0.017114906,
-0.01227068,
0.017469196,
-0.0038460847,
0.025931263,
0.002965471,
-0.018164149,
0.011364516,
0.003295914,
0.01663798,
0.009715707,
-0.011848257,
-0.0017663373,
0.008857236,
-0.014934664,
0.005729951,
0.029787568,
-0.00037728422,
0.011630233,
0.009572629,
-0.0028820084,
-0.007521838,
0.0017595241,
-0.011657486,
-0.032649137,
0.012768047,
0.020685054,
-0.014103446,
0.016419955,
0.0024272234,
-0.007971513,
-0.0009785544,
0.008005579,
0.01921339,
0.022074958,
-0.016460834,
0.005682258,
0.0032788808,
-0.013837729,
-0.034693114,
0.06502574,
0.013626518,
-0.003415146,
0.007896567,
0.013864982,
-0.0123388115,
0.007862501,
0.013272229,
-0.011091986,
0.008366682,
-0.009484056,
0.01003593,
-0.011275943,
-0.0053007156,
0.01312915,
0.012236613,
-0.008829984,
0.028860964,
-0.004053889,
-0.010097249,
-0.030359881,
-0.01030846,
0.024118936,
-0.004834007,
-0.02082132,
-0.04202418,
-0.011180558,
-0.004810161,
-0.020044608,
0.015139061,
0.014757519,
-0.010730883,
0.0024817295,
-0.003306134,
-0.003474762,
0.027893482,
-0.0046398295,
-0.014825651,
0.0091433935,
-0.013204096,
0.008666465,
0.03567422,
0.020521536,
0.0005182335,
-0.0111601185,
0.003852898,
0.009831533,
-0.022592766,
-0.022470128,
-0.018341294,
-0.040416252,
-0.01373553,
0.00915702,
0.01678787,
-0.01635182,
-0.029133495,
-0.041506372,
0.01070363,
0.035210922,
-0.05423354,
0.0051848902,
0.023860032,
-0.017278425,
-0.00608424,
-0.011255504,
-0.17256622,
0.017619088,
0.0001908777,
-0.02163891,
0.038372274,
0.00032277813,
0.01191639,
-0.011793751,
-0.004752248,
0.0036246537,
0.025781373,
0.023819152,
-0.037663694,
-0.008775477,
0.008543827,
-0.015506977,
0.0016428471,
0.020834945,
0.046030376,
0.009456803,
0.025345324,
-0.015520603,
0.009102514,
-0.028642941,
-0.01494829,
0.018886354,
-0.014062567,
-0.00521555,
-0.01647446,
-0.001096083,
-0.0068916115,
0.014471362,
0.013762783,
-0.004033449,
0.014730265,
0.0066327075,
0.005433574,
-0.001613039,
-0.0002130208,
0.00018076427,
0.019458668,
0.029787568,
0.012877059,
0.008414375,
-0.014348723,
0.016692484,
0.0023676076,
0.0047386214,
0.02078044,
0.0069563375,
0.044504207,
0.0116779255,
0.0017458976,
0.009715707,
0.011909576,
-0.018927233,
0.037200395,
0.0052359896,
0.016188303,
-0.0041969675,
-0.0048953267,
-0.019063499,
0.013285855,
0.009313725,
-0.016365448,
-0.031013954,
-0.03572873,
0.0023965638,
-0.026394565,
0.014457735,
-0.049518764,
0.020480657,
0.005471047,
0.006809852,
0.025958516,
0.008066898,
0.017441943,
0.027144024,
0.0025515654,
-0.0029637676,
-0.012400131,
-0.0046636756,
-0.019812956,
-0.018831847,
0.022674525,
0.00022654085,
0.031722534,
0.018518439,
-0.004411585,
0.003432179,
-0.0038460847,
-0.015997533,
0.005614125,
-0.034829378,
0.0023505744,
0.02328772,
0.027348422,
0.017891617,
-0.0017441943,
-0.009456803,
0.005147417,
-0.0038665244,
-0.02281079,
0.005627752,
0.037118636,
-0.012045842,
-0.009334165,
0.0010458352,
0.03646456,
-0.017946124,
-0.018722836,
0.004622796,
0.0023778274,
-0.010942094,
-0.0067791925,
0.015043676,
0.01160298,
0.0007043206,
0.010690004,
-0.020930331,
0.07134844,
0.02011274,
-0.006029734,
0.011037479,
0.0034917952,
-0.022224851,
-0.13266778,
-0.024554985,
0.008802731,
0.0052632424,
-0.035210922,
0.03384827,
0.009640762,
0.023042442,
-0.02617654,
0.033466727,
-0.0019281523,
-0.02782535,
-0.014716639,
-0.001125891,
0.017264798,
-0.013994434,
0.009293285,
-0.0065407287,
-0.021461766,
0.021965947,
0.009497683,
0.009007128,
-0.005600499,
-0.013769596,
-0.0063874302,
0.009252406,
-0.0057946765,
0.021311874,
0.004302573,
0.011105612,
0.025754118,
0.0027968427,
0.0028939317,
-0.006070614,
-0.024922902,
-0.0005510223,
-0.015547857,
-0.021734295,
0.024745757,
-0.03581049,
-0.0019179324,
0.012904312,
0.016256435,
0.02140726,
0.004513784,
-0.018886354,
-0.013367614,
0.0018004037,
0.025835877,
-0.0015679012,
-0.030741423,
-0.02613566,
-0.018518439,
-0.020221753,
0.011923203,
-0.035483453,
0.009177459,
0.018968113,
-0.025931263,
0.0032073415,
-0.006281825,
-0.007869314,
-0.015452472,
0.007474145,
-0.00067366095,
-0.005740171,
0.005297309,
-0.033466727,
-0.0044183983,
-0.027253035,
-0.010846708,
-0.016965015,
-0.018218655,
-0.017223919,
-0.013456186,
-0.001469109,
0.011821005,
-0.0016147423,
0.02343761,
-0.005617532,
-0.02176155,
-0.014266964,
0.024663998,
-0.00857108,
0.027580071,
0.0097565865,
0.0036927862,
0.0039925696,
-0.022034079,
-0.007998766,
-0.01097616,
0.031041207,
-0.021202862,
-0.04006196,
-0.009736147,
0.0059275352,
-0.006203472,
0.0033691565,
0.03978943,
0.03447509,
-0.020794066,
-0.01122825,
-0.05712236,
0.0069904034,
0.0038665244,
-0.018136894,
-0.012318372,
-0.01306783,
0.030959448,
0.010424286,
0.015425218,
0.021938693,
-0.0147438925,
0.005293902,
-0.008462068,
0.0082712965,
-0.021352753,
-0.010206262,
0.037064128,
0.01400806,
0.007739862,
0.028642941,
0.019581307,
-0.013994434,
0.010465166,
0.009913292,
-0.006929084,
0.01005637,
0.009668014,
0.043305073,
-0.031804293,
-0.0070312833,
-0.004030043,
-0.023805527,
0.0008618772,
0.011827817,
-0.0069733704,
-0.0061183064,
-0.0031034395,
0.01569775,
0.004302573,
0.04319606,
-0.03248562,
-0.03044164,
0.028888218,
-0.0018123268,
-0.011194184,
0.010288021,
-0.002197276,
0.017428316,
-0.03115022,
0.0015900442,
0.017387437,
0.0069188643,
-0.012917939,
-0.024704877,
-0.0012698211,
-0.0025260157,
-0.015929399,
-0.012604529,
-0.046084885,
0.012345625,
0.005266649,
-0.0012425681,
-0.007882941,
0.013040578,
0.013667397,
-0.024595864,
-0.022320237,
-0.0074264524,
0.0066872137,
-0.030877689,
-0.031450003,
0.01003593,
0.007072163,
-0.006806446,
-0.0059241285,
0.004541037,
-0.015343459,
0.021121103,
0.006591828,
0.036410056,
-0.002321618,
0.0011676223,
-0.034447838,
0.024841143,
0.014117072,
0.0057503907,
-0.0030829997,
0.009184273,
0.0014546308,
0.001866833,
0.00091212505,
0.025031913,
0.0144849885,
-0.0037949851,
0.011568913,
-0.0038903707,
-0.026271926,
0.019772077,
0.01565687,
0.014839278,
0.020834945,
0.01436235,
0.01463488,
-0.012229799,
-0.006748533,
0.009858785,
-0.035783235,
-0.024391467,
-0.02809788,
0.02433696,
0.02504554,
0.017959751,
0.019090751,
0.004541037,
-0.017537327,
0.013967181,
0.016760617,
-0.024636744,
-0.020794066,
0.0345841,
0.008230417,
0.013633331,
-0.009851973,
-0.012727167,
0.010512859,
0.009306911,
0.016011158,
-0.023342226,
0.014239711,
-0.0072833737,
0.03431157,
-0.017414689,
-0.050145585,
-0.0015048785,
0.01913163,
-0.012202547,
-0.004936206,
-0.0029910207,
0.0035497078,
0.053361442,
0.010717256,
-0.0071743615,
0.0024425534,
-0.030196363,
0.019445041,
0.027743591,
0.024405094,
-0.0144849885,
-0.036682587,
0.009552189,
-0.006598641,
0.0313955,
-0.017278425,
-0.029787568,
0.020194499,
-0.0016752101,
0.012413758,
0.004367299,
-0.0039482834,
0.012999698,
0.007855687,
-0.0004202929,
-0.00066301523,
-0.020589668,
0.006186439,
0.025345324,
0.009238779,
-0.0073719462,
-0.024159815,
0.007324253,
-0.00829855,
-0.012366065,
-0.017401064,
0.004837414,
-0.031640776,
-0.011991336,
-0.037472922,
-0.012236613,
0.025849504,
-0.0073855724,
-0.0036382803,
-0.02155715,
-0.03384827,
-0.013721904,
-0.009102514,
-0.010846708,
-0.011126052,
-0.0017884804
] |
Integrins are membrane receptors which mediate cell-cell or cell-matrix adhesion. Integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) acts as a fibrinogen receptor of platelets and mediates platelet aggregation. Platelet activation is required for alpha IIb beta 3 to shift from noncompetent to competent for binding soluble fibrinogen. The steps involved in this transition are poorly understood. We have studied a variant of Glanzmann thrombasthenia, a congenital bleeding disorder characterized by absence of platelet aggregation and fibrinogen binding. The patient's platelets did | [
-0.041192375,
-0.015995754,
0.004111306,
-0.016008975,
-0.01622049,
0.027100246,
-0.028818797,
0.012261209,
-0.02412583,
-0.02441666,
0.019075928,
-0.011877839,
0.0011021869,
0.0032222853,
-0.007264188,
-0.007865681,
0.025077643,
0.014700231,
-0.024681054,
0.00970982,
-0.020265697,
0.013827736,
0.0005746409,
-0.011745643,
-0.02224864,
0.019803008,
0.017423475,
-0.042223506,
-0.015784241,
-0.01509682,
0.009980822,
0.0052647186,
-0.010304703,
0.0099874325,
0.017502792,
-0.01976335,
0.013840955,
0.025950138,
0.009181035,
0.018520705,
0.010648414,
0.011567178,
0.0007312109,
-0.0057340153,
-0.0014235892,
-0.0017449914,
0.0027083722,
-0.015493409,
-0.0381783,
0.0075616296,
0.018150555,
0.006682524,
0.0010278265,
-0.0061967024,
-0.006860989,
-0.040795784,
0.0040352927,
0.01619405,
0.0054431837,
-0.01402603,
-0.023834996,
-0.024919007,
-0.013133705,
0.00025014023,
0.0012038128,
0.015229017,
0.014541595,
0.009775918,
-0.015162918,
-0.0009005874,
0.022526253,
0.0083349785,
-0.018031579,
-0.019498957,
0.017872943,
-0.031092575,
-0.026333507,
-0.037517317,
-0.02805206,
0.010469949,
0.0047921166,
-0.013682319,
0.00036230055,
0.03587808,
-0.0035726056,
0.0048483,
0.012875922,
0.020040963,
0.012955239,
0.0043723932,
-0.004633481,
0.007356725,
0.0055852947,
0.027496835,
0.0015343035,
0.012981678,
0.014819208,
0.008368027,
-0.0024704188,
0.0065668523,
0.019684032,
0.006368558,
-0.0051854006,
-0.025130522,
-0.029876368,
-0.019710472,
0.004844995,
-0.008520053,
0.015110039,
0.0075748493,
-0.022010688,
0.026465703,
0.011223468,
-0.05142437,
-0.0008898465,
-0.0052977675,
0.011362274,
0.00791856,
-0.0063784723,
-0.029876368,
0.014250764,
0.015969316,
0.020530088,
-0.008427516,
0.019803008,
0.03154204,
0.008784446,
-0.003879962,
-0.033551425,
0.0023679666,
0.025619647,
0.02121751,
-0.0046896646,
-0.006874209,
-0.015255456,
0.008506834,
-0.014607693,
-0.0000076167803,
-0.025342034,
-0.038046103,
0.0046797497,
0.029030312,
-0.0091215465,
-0.00090306613,
-0.0054497933,
0.016841812,
0.03193863,
0.0062826304,
0.007449263,
-0.00024518286,
-0.016365904,
-0.0045806025,
0.025632866,
-0.023213673,
0.0012732159,
0.009584233,
-0.0051589613,
0.0094057685,
0.001222816,
-0.008857153,
0.013563342,
0.010536047,
-0.007845852,
0.010734341,
0.029664854,
0.021468682,
-0.036089595,
-0.002977722,
0.00967677,
-0.031779997,
-0.0026026152,
0.03886572,
-0.017449914,
0.029664854,
0.004607042,
-0.0007320371,
0.006110775,
0.016736055,
-0.019789789,
-0.030616667,
0.0015772673,
0.00036725792,
0.027470395,
-0.00029207126,
-0.002321698,
0.006361948,
0.048621807,
-0.005420049,
0.009068668,
-0.022896403,
-0.0037775098,
0.0150571605,
0.011838181,
-0.025593208,
-0.629466,
-0.002551389,
0.032255903,
0.012386795,
-0.004263331,
0.024747152,
0.03304908,
-0.007515361,
0.0033726587,
0.010774001,
-0.01150769,
0.015493409,
0.002645579,
-0.010714511,
-0.02621453,
-0.00935289,
-0.014872086,
-0.017529232,
0.0042699412,
0.02695483,
-0.022063566,
-0.013331999,
0.012294258,
0.01509682,
-0.009233913,
-0.0059521394,
0.03511134,
-0.0135302935,
-0.007085723,
0.021336487,
-0.017568892,
0.030775303,
0.011454811,
0.014594474,
0.04922991,
-0.013854175,
-0.016841812,
0.02950622,
0.022407277,
0.024020072,
-0.005965359,
-0.009233913,
0.01579746,
-0.0077533145,
-0.013417927,
0.020582967,
0.000021740098,
0.013880613,
0.003916316,
0.002121751,
-0.0027133294,
-0.008387856,
-0.029611977,
0.012300868,
0.0038270834,
0.008876983,
0.021164631,
0.01364266,
-0.0019102369,
-0.0016210574,
0.0062231417,
0.008691908,
-0.01219511,
-0.033366352,
-0.013933492,
-0.017674647,
-0.012062915,
0.02478681,
0.012155452,
0.009504915,
0.02404651,
0.0065470226,
0.016022194,
0.0099874325,
0.017529232,
0.021164631,
0.0017317719,
0.04854249,
-0.017066546,
0.019578274,
0.01257848,
0.017767185,
-0.0029132764,
0.01828275,
0.026677217,
0.0059521394,
-0.03122477,
0.014687011,
0.009273572,
-0.007740095,
0.0117985215,
0.02045077,
-0.012267819,
-0.031066135,
-0.005684442,
0.03019364,
0.009663551,
0.008434125,
0.009742869,
-0.0099874325,
-0.00967677,
-0.0031033086,
0.028157817,
-0.0072443583,
0.01472667,
-0.013801296,
-0.055205185,
-0.010688073,
0.051926713,
-0.02658468,
-0.008070585,
-0.011950548,
-0.016749274,
-0.0035726056,
-0.0046301764,
-0.015215796,
-0.0029413681,
0.0011195376,
-0.013113875,
-0.01943286,
0.021349706,
-0.0064049116,
0.004276551,
0.0066065113,
0.01364266,
0.014184665,
0.004355869,
-0.022698108,
-0.021812392,
-0.007376555,
0.0031165283,
-0.012803214,
0.008916642,
-0.009511526,
0.021389365,
0.0022192458,
0.010238605,
0.020596188,
0.008394467,
-0.020781262,
-0.026280629,
0.0010740951,
0.021971028,
-0.015347993,
-0.009247133,
-0.005271328,
-0.025223058,
0.020622626,
0.013067606,
0.016577419,
0.0014029335,
0.009597453,
-0.0056183436,
0.0101923365,
0.013160144,
-0.021376146,
0.00078822055,
-0.018243093,
0.00860598,
-0.024866128,
-0.006143824,
0.009584233,
0.010582316,
-0.0024505893,
0.0063553383,
-0.010337752,
-0.0009873413,
-0.006490839,
-0.025553549,
-0.030828182,
0.009187644,
-0.018785097,
-0.030775303,
0.023213673,
0.0015772673,
0.032123707,
0.0037709,
-0.006801501,
-0.00395928,
0.008804275,
-0.016683176,
-0.04055783,
0.0061008604,
0.00824905,
0.03553437,
0.0027430737,
0.023491286,
0.0064181313,
-0.013166754,
0.022103224,
-0.020992776,
0.0073236763,
-0.016709615,
0.004897874,
-0.031462725,
-0.0041972334,
-0.0030107712,
0.0010947508,
-0.0381783,
0.02227508,
0.009967603,
-0.011765473,
0.009584233,
-0.003979109,
0.028131377,
-0.009068668,
0.004464931,
-0.009134766,
0.03561369,
-0.0034040553,
0.01223477,
0.012770165,
-0.007145211,
-0.014805988,
0.015942877,
-0.0049408376,
-0.006008323,
0.01220833,
-0.0023398749,
-0.0073236763,
0.0062000076,
0.015599166,
0.01435652,
-0.009399159,
-0.011772082,
-0.0063718627,
0.0110582225,
0.021058874,
0.0006337161,
-0.018507484,
-0.011639886,
0.0060149324,
0.028237134,
0.011904279,
-0.017370597,
-0.009789137,
0.008328368,
-0.0013632745,
0.008777835,
-0.007627728,
0.024892567,
0.012730505,
0.0054696226,
0.0067254878,
0.01796548,
-0.025249498,
0.0063057644,
0.008731567,
-0.0011269737,
0.023874655,
0.008460565,
0.02871304,
-0.010020481,
0.01076739,
-0.008599371,
0.0021432329,
0.014475497,
0.018983392,
0.031356968,
0.034291726,
0.018917294,
0.017013667,
-0.019498957,
0.0017218571,
0.007429433,
-0.007845852,
0.008235831,
-0.0066230358,
-0.021706635,
0.0026042676,
-0.004937533,
-0.0037147165,
0.0073501156,
-0.013503854,
-0.007792973,
0.0032768163,
0.0301672,
0.009029008,
0.0047127986,
-0.0089496905,
-0.016709615,
-0.052667014,
0.023821777,
0.030616667,
-0.016590638,
-0.013517074,
-0.0139863705,
0.0014235892,
-0.022433715,
-0.0010253477,
-0.0034701533,
-0.003450324,
0.009775918,
-0.00788551,
0.008526662,
-0.0028471784,
0.029532658,
-0.012228159,
0.0151364785,
-0.02187849,
0.0053870003,
-0.0032702065,
0.011745643,
-0.019340321,
0.053380873,
0.019961644,
0.005915785,
0.009828797,
0.0045211143,
-0.034714755,
0.01330556,
-0.010820269,
-0.0067453175,
-0.025778282,
0.006150434,
0.013391487,
0.009471866,
-0.0012930452,
0.028898116,
-0.018163774,
-0.016286587,
-0.01329234,
0.03408021,
-0.0034205797,
0.012241379,
0.02982349,
0.004778897,
0.01614117,
-0.0084142955,
0.011269736,
-0.031066135,
-0.024601735,
0.01686825,
-0.014237544,
-0.0005192837,
-0.023927534,
0.013503854,
0.0033693537,
0.002012689,
0.028633723,
-0.009471866,
-0.018454606,
0.01759533,
-0.0032239377,
0.007951609,
0.016696395,
0.029638415,
0.016987227,
0.023649922,
0.004458321,
-0.007964828,
0.016405564,
-0.002827349,
-0.020516869,
-0.0023051733,
-0.0021498427,
-0.009293402,
-0.002827349,
-0.013074216,
-0.04166828,
-0.01186462,
-0.007832632,
0.0033627439,
0.007792973,
0.010628584,
0.032255903,
0.0013161796,
0.0074558724,
-0.013021338,
-0.022909623,
-0.015347993,
-0.014171446,
0.017172301,
-0.018718999,
0.022354398,
-0.009088497,
-0.008639029,
-0.015295114,
-0.009683381,
-0.007726875,
0.013034557,
-0.014171446,
0.028845238,
-0.02977061,
-0.020292135,
-0.018137336,
0.00717826,
-0.035322856,
-0.0016474966,
-0.03561369,
-0.023517726,
-0.011064832,
-0.015731363,
0.0153876515,
0.0048251655,
-0.016273366,
-0.01904949,
0.0031347054,
0.0090752775,
0.011950548,
-0.0010897934,
0.007065893,
0.009604063,
0.043016683,
-0.017198741,
-0.034291726,
0.010641804,
-0.026201311,
0.000060366212,
-0.009789137,
-0.0057968087,
-0.0014624218,
0.023068259,
-0.0058496874,
0.013854175,
-0.019287443,
-0.019194907,
-0.012552041,
-0.00332639,
0.0025530416,
0.005063119,
-0.0053671706,
-0.009458647,
-0.0059389197,
-0.0025728708,
-0.019882327,
-0.017687868,
-0.030061444,
-0.00030673677,
0.012062915,
-0.009266962,
0.0026786278,
-0.026862292,
-0.014951404,
0.007938389,
0.0027282017,
0.005747235,
0.0064974492,
0.02260557,
0.025566768,
0.015916437,
0.007588069,
0.016855031,
-0.03704141,
-0.00045442485,
0.006398302,
0.026161652,
-0.006794891,
-0.029929247,
0.018798318,
0.009445427,
-0.0073236763,
-0.0036420086,
0.003323085,
0.0040485123,
0.026888732,
0.025791502,
0.0029017092,
-0.0208077,
-0.00046433957,
-0.004669835,
-0.0024208452,
-0.018600022,
0.0026406215,
-0.0029132764,
0.017899381,
0.0045211143,
0.00521845,
-0.014779549,
-0.031912193,
-0.012076134,
0.017013667,
-0.041588962,
0.012380186,
-0.001743339,
-0.0061140796,
-0.01726484,
-0.0244431,
-0.034291726,
-0.03511134,
-0.027814105,
-0.023478067,
0.02950622,
0.03947382,
0.028607285,
0.027840545,
0.032916885,
-0.0062826304,
0.0012360356,
0.017687868,
0.0030206859,
0.011342444,
0.0049771913,
0.030484471,
0.001954853,
0.0042302823,
0.05430625,
-0.008962911,
0.03947382,
0.007647557,
-0.012955239,
-0.011970377,
-0.0045772977,
-0.033207715,
-0.02371602,
0.020226037,
0.014435838,
0.0049705817,
-0.04354547,
-0.0048317756,
-0.01473989,
-0.013721978,
-0.0047822017,
0.009782528,
0.024020072,
-0.011970377,
0.026782975,
-0.0020721774,
0.018547144,
-0.00341397,
-0.014673792,
0.009465257,
0.0051589613,
0.024839688,
0.023782117,
0.0042996854,
-0.02157444,
-0.010000652,
-0.031145453,
-0.0060810307,
-0.006008323,
-0.01223477,
0.0057207956,
-0.0064974492,
0.0029017092,
-0.013259291,
-0.017357377,
-0.017753966,
-0.01870578,
0.004884654,
-0.022222202,
0.020953117,
-0.0004502937,
-0.013186583,
0.0417476,
-0.011401933,
0.039262306,
-0.015030722,
0.02908319,
0.00014562251,
0.010311313,
-0.021243948,
-0.008149903,
-0.0021630623,
0.0044748452,
0.027100246,
0.0083349785,
-0.01223477,
-0.033868697,
-0.019921986,
0.0021795868,
-0.016643517,
-0.015321554,
0.021442244,
0.015638825,
-0.003126443,
-0.008559712,
-0.018467827,
-0.01832241,
0.030458033,
0.01076078,
0.0030091188,
0.01721196,
-0.0032850786,
-0.019988084,
0.030325836,
-0.001080705,
0.01615439,
0.00862581,
-0.023134356,
0.01869256,
-0.018917294,
-0.0010270001,
-0.012347137,
0.00026914343,
0.021111753,
-0.0064445706,
0.0022175934,
0.008401076,
-0.0075219707,
0.0073435055,
-0.0037081067,
0.00026583855,
0.03735868,
0.0029909417,
-0.006794891,
0.028633723,
0.018917294,
-0.0065602423,
-0.010258434,
0.011025174,
-0.00014748152,
-0.025289156,
-0.016418783,
0.025765063,
0.0018391813,
-0.021719856,
0.024866128,
-0.01296185,
-0.0007613682,
-0.02439022,
-0.020173158,
0.0008774531,
-0.042910926,
-0.02658468,
-0.0002435304,
0.009504915,
0.008936471,
-0.015255456,
0.007872291,
-0.0043657837,
0.024231585,
-0.031647798,
0.011547348,
0.0019680727,
0.013880613,
-0.013054387,
-0.013318779,
-0.0009914724,
-0.015506629,
0.010536047,
-0.0099411635,
-0.013946712,
0.0011335835,
-0.0092801815,
-0.008116854,
0.014158226,
-0.03201795,
0.008070585,
-0.012902361,
0.03384226,
0.022962501,
0.0118514,
-0.015744582,
-0.01652454,
0.018996611,
0.004564078,
0.0060810307,
-0.015533067,
0.015427311,
-0.012829653,
0.0034337994,
-0.0030322531,
-0.0087447865,
-0.01618083,
0.02121751,
-0.0150836,
-0.0063817776,
-0.01435652,
-0.021666978,
-0.015004283,
0.015995754,
0.005813333,
-0.022235421,
-0.015493409,
0.01042368,
0.013880613,
0.027126685,
-0.020596188,
0.0031016562,
0.019565055,
-0.014634132,
-0.014607693,
-0.006421436,
-0.016260147,
0.025553549,
-0.011765473,
0.00538039,
-0.02263201,
-0.0026521888,
-0.03661838,
-0.017026886,
-0.00013643074,
0.0037411558,
0.0064181313,
0.0208738,
-0.01577102,
0.015506629,
-0.010516217,
-0.004174099,
-0.017106203,
-0.0059818835,
0.023385528,
-0.026849072,
-0.004312905,
0.013893833,
-0.039077234,
-0.023292992,
0.055046547,
-0.021891711,
-0.0091215465,
0.025646087,
-0.0044748452,
0.021124972,
-0.0033164753,
0.0034932878,
0.0032933408,
0.01365588,
0.03733224,
-0.032837566,
-0.006256191,
-0.010621974,
0.0020506955,
-0.018401727,
0.024614954,
-0.0027050672,
-0.0036122645,
0.026148433,
0.009927943,
-0.03423885,
0.011177199,
-0.013801296,
0.027206004,
0.0070328442,
-0.0064445706,
0.0066759144,
0.01583712,
0.007515361,
-0.0032156755,
0.00682794,
-0.010608755,
-0.010529437,
0.014330082,
-0.026716877,
-0.031066135,
0.006722183,
-0.029294705,
-0.0053770854,
0.009762698,
0.01116398,
-0.024522418,
-0.017079765,
0.0032586392,
0.013490635,
-0.006209922,
-0.0034734583,
-0.020516869,
-0.010337752,
-0.012115792,
-0.00002860811,
0.0007402994,
0.011646496,
-0.03667126,
0.014078909,
0.003071912,
0.0039394503,
0.0057968087,
-0.016432002,
-0.0029364107,
-0.00057050976,
0.18592091,
-0.017172301,
0.0003806841,
0.00790534,
0.00013756679,
-0.012241379,
0.007997877,
-0.016207268,
0.0027331589,
0.012796604,
0.039103672,
0.019684032,
-0.009729649,
-0.0066164257,
0.008890202,
-0.00014882414,
-0.01689469,
0.0042963806,
-0.011824961,
0.0022589047,
-0.00018022077,
-0.020781262,
0.012611529,
-0.010674853,
0.035640128,
-0.007726875,
-0.012320697,
0.0013095698,
0.017159082,
0.012803214,
-0.011844791,
0.014554815,
-0.010311313,
0.015731363,
0.0038832668,
-0.0065205838,
-0.00013147337,
0.003774205,
-0.0013979761,
0.01981623,
-0.013708758,
0.010873147,
-0.034344602,
-0.008572931,
-0.007588069,
0.016656736,
0.017529232,
-0.011560569,
-0.010000652,
0.030458033,
-0.033974454,
-0.013682319,
-0.023438407,
0.035666566,
-0.016577419,
-0.009875066,
0.0041972334,
0.019644374,
0.000480451,
0.010542656,
-0.015110039,
-0.0073501156,
-0.0151364785,
0.03410665,
-0.020252476,
0.045528412,
-0.0043261247,
0.009723039,
-0.015229017,
-0.009214084,
-0.006358643,
0.012928801,
-0.023478067,
0.014885305,
-0.021706635,
-0.014554815,
0.03056379,
0.016458442,
0.03122477,
0.011329224,
0.012968459,
0.014290422,
-0.022777427,
0.012380186,
-0.020437552,
-0.024205146,
0.014858866,
0.016207268,
-0.012651188,
-0.012624749,
0.005674527,
-0.006794891,
-0.021204289,
0.008843934,
-0.0045508584,
-0.016392345,
-0.009359499,
-0.014845647,
-0.013358438,
-0.016207268,
-0.023491286,
0.085240185,
0.017582111,
0.0032322002,
-0.021085313,
0.007508751,
-0.01296185,
0.0136691,
-0.012406625,
0.014078909,
-0.03622179,
-0.02195781,
-0.0059488346,
-0.012069524,
-0.018956952,
0.018613242,
0.019551836,
-0.0053770854,
0.025857601,
-0.009683381,
-0.008685298,
-0.011415152,
0.013120485,
0.025249498,
-0.010575706,
0.01472667,
-0.005063119,
0.022684889,
0.0053341216,
-0.020649066,
-0.02695483,
0.015374432,
0.0127899945,
-0.026333507,
-0.014528376,
0.007892121,
0.016656736,
0.0040782564,
-0.012657798,
0.021614099,
-0.01436974,
-0.026862292,
0.026650779,
0.011983597,
-0.007165041,
-0.01903627,
0.029347584,
0.013127095,
-0.02977061,
0.0002598484,
-0.010410461,
-0.021481901,
0.013503854,
-0.027258882,
0.037940346,
0.0029975516,
-0.003559386,
-0.030405154,
0.02485291,
-0.004170794,
-0.010496388,
0.029664854,
0.029744172,
-0.033577867,
-0.020741602,
0.0001552274,
-0.16529828,
0.010020481,
0.0018243092,
-0.024205146,
0.037173606,
-0.01833563,
-0.014779549,
-0.002554694,
0.002500163,
-0.016617078,
0.036353987,
-0.02187849,
-0.026439264,
-0.020992776,
0.00683455,
-0.004451711,
-0.014819208,
0.0051523517,
0.002569566,
0.009227303,
0.03487339,
-0.029030312,
0.0034205797,
-0.033604305,
0.020093841,
0.0004502937,
0.011401933,
-0.01436974,
-0.0029562402,
-0.010542656,
0.009947773,
-0.0002908319,
0.03741156,
0.01755567,
0.013761637,
-0.010807049,
0.0019003222,
-0.0044781505,
0.0042996854,
0.014898526,
0.029056752,
0.027840545,
-0.0039394503,
-0.0011748949,
-0.0052283644,
0.038574886,
0.02008062,
-0.001590487,
0.031885754,
-0.002551389,
0.025223058,
-0.015982535,
0.017304499,
0.029215386,
0.051133536,
0.019340321,
0.009914724,
0.01076739,
-0.003359439,
0.0043690884,
0.0043723932,
0.0046599205,
0.037094288,
-0.0265979,
-0.009458647,
-0.016775712,
-0.000023353823,
0.004709494,
-0.0208077,
0.021481901,
-0.0063454234,
-0.005615039,
-0.003075217,
-0.041086618,
0.025051203,
0.027734788,
-0.031753555,
-0.0029314535,
0.0071584308,
-0.007852461,
-0.020437552,
0.017529232,
-0.017132644,
-0.028475087,
-0.012314088,
0.009187644,
0.015903218,
0.012875922,
-0.011018563,
0.0018127421,
0.024628175,
-0.03423885,
-0.002278734,
-0.021812392,
0.018520705,
0.004587212,
0.01544053,
-0.0017020276,
-0.022341179,
0.0048945686,
0.028263573,
-0.009174424,
-0.019723691,
0.00663956,
0.0069997953,
-0.010344362,
0.021389365,
-0.0033214325,
0.031409845,
-0.0029017092,
-0.0025646086,
-0.014805988,
0.003250377,
0.03296976,
-0.012644578,
0.030854622,
-0.0073038465,
-0.00043046428,
0.01690791,
-0.015757801,
0.06435317,
-0.0056249537,
-0.0018804927,
0.023768898,
-0.024720712,
-0.02873948,
-0.13304238,
0.00412122,
0.029982125,
0.010754171,
0.011177199,
-0.00092867913,
-0.014885305,
0.0019779874,
-0.01006014,
0.0041542696,
-0.05092202,
-0.006428046,
-0.016075073,
-0.027972741,
0.007997877,
0.008910032,
-0.016339466,
-0.0071584308,
-0.026346726,
0.02587082,
-0.028686602,
-0.022883182,
0.019313883,
0.004897874,
-0.0020027743,
-0.0038931817,
-0.010245215,
0.021283608,
-0.009914724,
0.017066546,
0.0067684515,
-0.00717826,
0.018229872,
-0.001546697,
-0.03415953,
-0.038310494,
-0.0067089633,
-0.005079644,
0.017053325,
-0.012538821,
0.0124595035,
-0.0016755883,
0.001546697,
-0.034556117,
-0.019684032,
0.008777835,
-0.047299843,
0.0073104566,
0.015533067,
-0.024760371,
-0.01908915,
-0.032203022,
-0.02871304,
-0.03627467,
0.02045077,
0.015149699,
-0.009551184,
0.023187235,
-0.019128807,
0.0222883,
-0.010549267,
-0.002878575,
-0.03339279,
0.0019201515,
0.02871304,
-0.019723691,
-0.0075285803,
-0.01615439,
0.028871676,
-0.0055092815,
0.022446936,
0.0029578926,
-0.010707902,
-0.011296175,
-0.005664612,
0.020675505,
-0.011408542,
-0.015374432,
0.0012269471,
-0.0140656885,
-0.020516869,
-0.015929656,
0.018097676,
-0.0065602423,
-0.005634868,
0.005020155,
-0.019895546,
0.009914724,
0.021495122,
-0.015017502,
-0.030458033,
0.04846317,
0.03196507,
-0.011745643,
0.0030306007,
0.02802562,
-0.021402584,
-0.035507932,
0.019617934,
0.024337342,
-0.047987264,
-0.00431621,
-0.05071051,
0.0055291113,
-0.0007200568,
0.016802153,
0.012552041,
-0.007872291,
0.004164184,
-0.009643721,
0.0012575175,
0.0016483229,
-0.0078789005,
0.020530088,
-0.006874209,
0.010959075,
-0.013695539,
-0.031356968,
0.060863186,
-0.002911624,
0.011534129,
0.03125121,
-0.02655824,
-0.004012158,
0.006206617,
0.010655023,
0.017714307,
-0.0073038465,
-0.02088702,
0.022156103,
-0.011064832,
0.031753555,
-0.0063553383,
-0.055522453,
-0.018441387,
-0.009650331,
-0.008063976,
-0.041588962,
-0.0101923365,
0.01900983,
0.016101511,
0.027364638,
-0.0015227364,
-0.008804275,
0.016802153,
-0.019631153,
-0.0024224976,
0.008533273,
-0.041483205,
0.008301929,
0.00087910553,
-0.0051126927,
0.01870578,
0.0139863705,
-0.002151495,
-0.03376294,
-0.009927943,
0.0112168575,
0.0017879553,
-0.0042600264,
-0.0011905931,
-0.036935654,
0.044708796,
0.009194254,
-0.011732424,
0.014197885,
0.01729128,
-0.033868697,
-0.025831161,
0.014435838,
0.012135622,
-0.013801296,
-0.012677628,
-0.0037907294,
-0.0038700474,
-0.00067337503,
0.003949365,
0.030378714,
-0.021085313,
-0.012485943,
0.0020044267,
0.03347211,
0.03378938,
0.010364192,
-0.026148433,
-0.008883593,
0.0071980897,
-0.01076078,
0.0015747887,
0.027840545,
0.013708758,
-0.007812803,
0.013616221,
0.019075928,
0.012294258,
-0.003071912,
0.0065205838,
0.028210696,
0.00449798,
0.036168914,
0.00016462573,
0.030140761,
0.0022803866,
0.008705128,
0.0025282546,
-0.014779549,
-0.018124115,
0.008103634,
-0.021164631,
-0.051556565,
-0.011197029,
-0.0018887549,
0.020900238,
0.012043085,
0.0103509715,
-0.009240523,
-0.0030653023,
-0.02156122,
0.0037279362,
0.0035098123,
-0.027840545,
0.024284463,
0.0036353988,
-0.0014293727,
-0.013867394,
-0.020067401,
0.014118567,
-0.0085398825,
0.03170068,
-0.01908915,
0.01257187,
-0.01471345,
-0.008685298,
-0.0021597573,
-0.027153125,
0.004488065,
0.0193932,
-0.0047921166,
0.0072443583,
0.031066135,
-0.010774001,
0.08180308,
0.022222202,
-0.011011953,
0.0070262346,
-0.015823899,
0.02121751,
-0.010582316,
0.012010036,
-0.03801966,
-0.025011543,
-0.00009119481,
-0.0069270874,
0.00032408754,
-0.03987041,
-0.023306211,
0.026901951,
-0.00032780555,
0.012320697,
-0.0011418457,
-0.0077136555,
0.009914724,
-0.03233522,
0.00007782026,
0.007726875,
-0.024932226,
0.0075021414,
0.008374637,
0.0027463785,
-0.0038237786,
-0.031806435,
0.0004808641,
-0.012162061,
-0.038125418,
-0.0037940345,
0.017780405,
-0.017912602,
-0.027655471,
-0.024165487,
0.0043261247,
0.03381582,
-0.007997877,
0.03296976,
-0.03304908,
-0.027946303,
-0.011613447,
-0.0071584308,
-0.04127169,
-0.011560569,
-0.012644578
] |
During meiosis, recombination between homologous chromosomes generates crossover (CR) and noncrossover (NCR) products. CRs establish connections between homologs, whereas intermediates leading to NCRs have been proposed to participate in homologous pairing. How these events are differentiated and regulated remains to be determined. We have developed a strategy to detect, quantify, and map NCRs in parallel to CRs, at the Psmb9 meiotic recombination hot spot, in male and female mouse germ lines. Our results report direct molecular evidence for distinct CR and NCR pathways of DNA double-strand break (DS | [
-0.027811147,
0.0056485026,
-0.00091282924,
-0.0137832975,
-0.025732445,
0.018749088,
0.007479256,
0.00057019986,
-0.016738316,
-0.009462855,
0.013192293,
0.0032216504,
-0.014809063,
0.0010096317,
0.004785773,
0.010019894,
0.02732204,
0.0053190347,
0.0035358334,
-0.02406133,
-0.03722645,
-0.010216895,
0.007662671,
-0.030541994,
0.006606336,
0.016670385,
0.020637583,
-0.022648355,
0.00015486254,
0.00018553785,
-0.003219952,
0.013912367,
0.0023096702,
-0.016371487,
-0.007221116,
0.004575185,
0.0059745735,
-0.0016193166,
0.0047178413,
-0.026180793,
-0.0036479204,
-0.010413896,
-0.016453005,
0.011113591,
0.015787276,
0.0060560913,
-0.0055567953,
-0.016235624,
-0.0130020855,
0.030759374,
0.0027240524,
0.017648598,
-0.03238973,
0.0017832014,
-0.010230481,
-0.008464263,
0.0028667084,
0.0142248515,
-0.0025695083,
-0.0013832548,
-0.011826871,
0.016425831,
-0.02692804,
0.015814448,
-0.013851229,
-0.003213159,
0.0108758295,
-0.014646027,
0.011786112,
-0.0076898434,
0.020854965,
0.003770197,
-0.0016040321,
0.0076083257,
0.01208501,
-0.0051390165,
-0.0078664655,
-0.017811634,
-0.0069493903,
-0.0012669221,
0.023762431,
-0.011894803,
-0.0075607738,
0.022444561,
0.00979572,
0.0004882575,
0.0067150267,
0.01171818,
0.0041879755,
-0.000022343089,
0.011167935,
0.028993156,
0.019754475,
0.0058556935,
-0.030270267,
0.008077053,
0.003124848,
0.019577853,
-0.00440196,
-0.02069193,
-0.0027682078,
0.009089232,
0.009619097,
-0.017281769,
-0.027648112,
-0.0015063806,
0.001580256,
-0.024767818,
0.012852636,
-0.009340579,
-0.015325342,
0.019374058,
0.00015666698,
-0.03565044,
0.021262553,
-0.017404046,
0.022675527,
-0.013246639,
-0.0049861707,
-0.0033048666,
0.014917753,
0.0031622103,
0.009442476,
-0.024088502,
0.0076151188,
0.03700907,
-0.014686786,
0.005325828,
-0.003408462,
-0.012560531,
0.024156434,
0.00033052912,
0.010067445,
0.025297683,
-0.027906252,
0.020637583,
-0.0023317481,
-0.00025474306,
-0.009816099,
-0.049861707,
0.009938375,
0.027118247,
-0.01370178,
-0.0029261485,
0.009924789,
0.03206366,
0.015664998,
0.005838711,
0.0041574067,
0.0025898877,
0.005475277,
0.011229074,
0.026765004,
0.0006270925,
0.010576932,
0.02673783,
0.01208501,
0.014455819,
-0.01089621,
-0.0341016,
0.0056111403,
0.009449269,
0.015746517,
0.011561938,
-0.005668882,
0.0273628,
-0.018586053,
0.004653306,
-0.0145645095,
-0.021153864,
0.0037668005,
0.010257654,
-0.02820515,
0.025650928,
-0.009992721,
-0.0063753696,
-0.003432238,
-0.009707409,
-0.033177733,
-0.009836478,
0.0034882815,
-0.018504536,
0.02732204,
-0.00018479486,
-0.02923771,
-0.008668057,
0.007030908,
-0.010943761,
-0.025175406,
0.003746421,
-0.009259061,
0.0083148135,
0.008851472,
-0.028558394,
-0.6221437,
-0.0016762093,
0.009870444,
-0.026792176,
0.0142248515,
0.016412245,
0.015909553,
0.016330728,
-0.0084235035,
0.024020571,
-0.007947983,
0.018694744,
0.029645298,
-0.011045659,
-0.031166963,
-0.043747872,
0.014279197,
0.02050172,
0.031493034,
0.023395602,
-0.016059002,
-0.014252025,
-0.014075403,
0.008620505,
-0.018001841,
-0.0061647817,
0.031493034,
0.016208451,
-0.015597068,
0.0011089814,
-0.022281526,
-0.01499927,
-0.012988499,
-0.0058421073,
0.0530409,
0.0059813666,
0.0073705656,
0.030025715,
0.031954966,
0.04404677,
-0.018423017,
0.0006912028,
0.019795233,
0.015556309,
-0.014387888,
-0.0051627923,
-0.0060221255,
-0.012954533,
0.009714202,
0.006219127,
-0.020814205,
0.0021585228,
-0.03459071,
0.016914938,
0.0024166624,
0.00094339845,
0.0256781,
-0.008206123,
0.009598718,
0.014143334,
-0.021901108,
-0.0058013485,
-0.022091318,
-0.032253865,
-0.022430975,
-0.010712794,
-0.018898537,
-0.024659127,
0.015909553,
0.014741131,
0.0019581248,
0.02520258,
-0.0025423355,
-0.001757727,
-0.009340579,
0.013300984,
-0.009218302,
0.004823135,
-0.001461376,
0.010332379,
0.010244067,
-0.015909553,
-0.022988012,
0.012166528,
0.021398416,
-0.025216166,
0.008946576,
0.0049691875,
0.0022570235,
0.0010385026,
-0.008396331,
0.0061987475,
0.003634334,
-0.024183607,
-0.013355329,
0.014550923,
0.004823135,
-0.0040079574,
-0.0002239616,
-0.024156434,
0.0053224317,
0.000107947366,
-0.008899024,
-0.014211265,
0.0070377016,
0.0055364156,
-0.016480178,
0.013117569,
0.012927361,
-0.027960597,
-0.01672473,
-0.017064387,
-0.0166568,
-0.011779319,
-0.012526565,
-0.021941869,
0.023735259,
0.014646027,
0.010583725,
-0.021412002,
0.01849095,
0.0049284287,
-0.009163957,
-0.02486292,
0.022200007,
0.003627541,
-0.009082438,
-0.008056673,
0.0025610167,
-0.007248289,
-0.009286233,
-0.010712794,
0.0026323448,
-0.014700373,
-0.002231549,
0.00008884164,
0.0015488378,
-0.00673201,
-0.0024506282,
-0.03524285,
-0.032742973,
-0.0071463916,
-0.016942112,
0.016629627,
-0.007221116,
-0.01959144,
-0.042199034,
0.00015709155,
0.012961326,
0.004785773,
0.014972098,
-0.005206948,
-0.016683972,
0.011419281,
-0.017485563,
0.0015862001,
-0.02259401,
-0.017852392,
-0.0073365998,
-0.023354843,
-0.0005880319,
0.014768303,
-0.010454655,
-0.0060560913,
-0.010427482,
-0.008212916,
0.023517879,
0.0053937593,
-0.0048367213,
-0.024360228,
-0.002326653,
-0.015203065,
-0.039291568,
0.022838563,
0.0043510115,
0.026955212,
-0.007893638,
0.0012643747,
0.021724487,
-0.0046838755,
0.0013390993,
-0.024604782,
-0.03660148,
-0.033585325,
0.0010987917,
0.0019241591,
0.043639183,
-0.01137173,
0.015094375,
0.037797075,
-0.017444804,
0.006871269,
-0.009021301,
0.015828036,
0.024414575,
-0.014238439,
-0.009435683,
0.015529136,
0.0038415252,
0.03535154,
0.012356736,
-0.019686542,
0.011813285,
-0.012954533,
0.022444561,
-0.030868065,
0.020474548,
-0.015556309,
0.018192051,
-0.0039909743,
0.00757436,
-0.0069324076,
-0.0018256585,
-0.009265854,
0.0016880973,
-0.00550245,
-0.036438446,
0.015814448,
0.011283419,
0.0025015767,
-0.023748845,
-0.013925954,
0.020623997,
0.00054515013,
-0.0010104808,
0.0030382355,
0.009979134,
0.005149206,
0.00550245,
0.0042660967,
-0.0038041628,
0.027756803,
-0.008661264,
-0.003425445,
0.0112154875,
0.014741131,
0.011045659,
0.00305352,
0.016317142,
0.008729195,
0.005356397,
0.021955455,
-0.0013407976,
-0.0011854044,
-0.0053869663,
-0.022648355,
0.020583238,
0.035297196,
0.01603183,
0.015828036,
-0.024441747,
0.0045887716,
-0.044291325,
0.016167693,
0.021534279,
-0.018192051,
0.0065757674,
0.008620505,
0.05491581,
0.015895966,
-0.014102575,
-0.005645106,
0.012173321,
-0.012825464,
-0.008926196,
0.005672279,
0.018164877,
-0.0037905765,
-0.01782522,
-0.012805084,
0.0019071763,
-0.019496335,
-0.008212916,
-0.011263039,
-0.023327671,
0.007771361,
0.017567081,
0.01760784,
0.01845019,
-0.008471056,
-0.023083117,
-0.029944196,
0.039291568,
0.018545294,
-0.011677422,
-0.013029258,
-0.010352758,
0.011378523,
-0.013525157,
0.027159005,
0.011405695,
0.009021301,
0.020012613,
0.01603183,
-0.019278955,
-0.025474304,
0.028395358,
-0.02274346,
0.0290475,
0.012981706,
0.015732931,
0.03143869,
0.004666893,
-0.013694987,
0.039291568,
-0.01551555,
-0.006402542,
-0.021765247,
-0.0016931922,
-0.013599882,
0.0016108252,
0.010305205,
-0.0141161615,
-0.007499635,
-0.011072831,
-0.022757046,
0.0050507057,
-0.011928768,
0.002277403,
0.0068135276,
-0.039536122,
-0.023803191,
-0.0043000625,
-0.017879566,
0.03787859,
0.035134163,
-0.021004414,
0.020950068,
-0.002822553,
0.00051288266,
-0.0070377016,
-0.016670385,
0.018504536,
-0.019482749,
-0.00031949024,
-0.008457469,
0.011636662,
0.016208451,
-0.001822262,
0.023123875,
0.016779076,
-0.03543306,
-0.005937211,
0.025909066,
0.008634091,
-0.021873936,
0.016588867,
0.042905524,
0.0059677805,
-0.008613711,
0.024034157,
0.0029244502,
0.019727303,
-0.028014943,
-0.004374787,
0.021941869,
0.003372798,
0.0040079574,
0.006083264,
-0.015243825,
0.022661941,
-0.0025932842,
0.009965548,
-0.0048604975,
0.013199086,
0.018477362,
0.018844193,
0.0033524185,
0.0073841517,
-0.015664998,
0.01713232,
0.011385316,
-0.003929836,
-0.0014800571,
0.0064059384,
-0.021724487,
-0.0019445387,
-0.002491387,
-0.0032844872,
-0.007927604,
-0.010169342,
-0.02699597,
-0.011201901,
-0.016901352,
-0.009347372,
-0.008606918,
0.03918288,
-0.0062972484,
-0.019686542,
-0.013565917,
-0.021466348,
-0.032118004,
-0.037253622,
-0.013409674,
-0.0015420446,
-0.02923771,
-0.025284097,
0.0030755978,
0.0038109561,
0.024550436,
0.022172835,
-0.011697801,
-0.01085545,
0.01870833,
-0.017363286,
-0.026221551,
-0.0015259109,
-0.010311998,
-0.0036071616,
0.0004963244,
-0.0053224317,
-0.017920325,
-0.020841379,
0.018681157,
-0.0022026782,
-0.025705272,
-0.0020549272,
-0.0023317481,
-0.020202823,
0.026941625,
-0.016181279,
0.045459747,
0.009659857,
-0.0047144447,
0.002284196,
-0.044182636,
-0.03690038,
-0.03268863,
0.004585375,
-0.009034887,
-0.011276626,
0.012737152,
-0.0032997716,
0.0034101603,
0.020950068,
-0.03092241,
0.0044834777,
0.021004414,
0.028667085,
0.03722645,
-0.0032454266,
0.027498662,
-0.0033812893,
-0.0075471876,
0.007988742,
0.0025406373,
0.030433303,
0.021683728,
-0.010651656,
0.023273325,
-0.019496335,
-0.015556309,
-0.010284826,
0.028395358,
-0.004561599,
0.034672227,
-0.0033235478,
-0.038911153,
0.0043917703,
-0.0049963603,
0.007927604,
0.029917024,
0.0013204181,
0.00647387,
-0.011364937,
0.018205637,
-0.0059202285,
-0.016697558,
0.0045378227,
-0.033286426,
0.019129505,
0.011636662,
-0.014143334,
0.0061919545,
0.0017645202,
0.0013348536,
-0.020678343,
-0.03209083,
-0.008661264,
-0.018056188,
0.011385316,
-0.020121304,
0.034346156,
0.038449217,
0.030351786,
-0.017173078,
0.015705759,
0.005726624,
0.01452375,
0.0016142218,
-0.003579989,
0.025093889,
-0.016670385,
0.031683244,
0.007852879,
0.015461205,
-0.0070920466,
-0.0031740984,
0.022634769,
0.019645784,
-0.013083603,
-0.029400745,
0.010631276,
-0.055214707,
-0.0030467268,
-0.0025406373,
0.0063040415,
0.00047806778,
-0.023708086,
0.0049318257,
0.026724244,
-0.001065675,
0.022607597,
-0.007166771,
0.03157455,
-0.004945412,
0.020121304,
-0.02725411,
0.026534036,
-0.025188994,
0.0000068793893,
-0.019496335,
-0.01124266,
0.019170264,
-0.02956378,
0.024523264,
0.010298412,
-0.027294869,
-0.007771361,
0.005302052,
-0.033938568,
-0.011290212,
-0.007261875,
-0.014482992,
0.012642048,
-0.0039196466,
-0.0016719636,
-0.021344071,
0.007064874,
0.0029567177,
-0.012934154,
0.017621426,
0.0041642,
-0.022036972,
0.026289484,
0.0034543157,
0.019007228,
-0.027009556,
0.0027716043,
0.0047619967,
-0.0046600997,
-0.02464554,
-0.020515308,
0.0034050655,
-0.0033235478,
0.05543209,
0.023137461,
0.008294433,
-0.016086174,
-0.0006512931,
-0.012118976,
-0.027430732,
-0.04676403,
0.0011964432,
0.0025610167,
0.0018749088,
-0.015542722,
-0.000033196204,
-0.006776165,
0.0104342755,
-0.0145645095,
0.007390945,
0.012852636,
-0.022498906,
-0.024767818,
0.026765004,
-0.0038313356,
0.026601968,
-0.009102819,
-0.01305643,
-0.011174728,
-0.015298169,
-0.0122208735,
-0.0038041628,
0.020963654,
0.03950895,
-0.0121053895,
-0.014279197,
0.010848657,
-0.002005677,
-0.034835264,
-0.013749331,
-0.0031333396,
0.043014213,
-0.0031724002,
-0.0049318257,
0.011514386,
0.03532437,
0.0076966365,
0.0045480127,
-0.0072279093,
-0.015366101,
-0.04695424,
0.0017390458,
0.029944196,
0.015760103,
-0.020556066,
-0.0073841517,
-0.004989567,
0.017091561,
-0.0383677,
-0.020297926,
0.028585566,
-0.038150318,
-0.017186664,
0.00095528644,
0.026275897,
0.027131833,
-0.017363286,
0.0062395064,
0.00018882829,
0.021656556,
-0.021058759,
0.018871365,
0.0074588764,
0.016439417,
-0.0134504335,
0.0069154245,
0.0031095636,
-0.019319713,
0.018259982,
-0.019075159,
-0.027417146,
0.014795477,
0.0028565188,
0.012152942,
0.0028735015,
-0.004242321,
0.000615629,
0.015067202,
0.016439417,
0.009945169,
-0.0053937593,
0.01331457,
-0.01775729,
-0.0024302488,
0.013267018,
-0.019129505,
-0.0031486242,
-0.023327671,
-0.004507254,
0.021656556,
-0.016222037,
0.008355572,
0.0046023577,
-0.0050473087,
0.021357657,
-0.0073977383,
-0.0041608033,
0.0031639086,
-0.03741666,
0.013694987,
0.006871269,
-0.032579936,
-0.0014477897,
-0.0021143672,
0.002041341,
0.014401474,
-0.014659613,
0.00007907649,
0.01208501,
-0.031194136,
-0.03983502,
-0.008987335,
-0.00043900718,
0.031357173,
0.032308213,
-0.024455333,
-0.013396088,
-0.013715366,
-0.034318984,
-0.031846277,
-0.0003005968,
0.0069018384,
0.023449946,
0.02453685,
-0.0038007663,
0.03491678,
0.003077296,
0.0083148135,
-0.005971177,
-0.009503614,
0.025936238,
0.0074249106,
0.033041872,
0.020148477,
-0.043041386,
0.01577369,
0.03385705,
-0.014578096,
0.009890824,
0.015895966,
0.0066844574,
0.026982384,
0.004031733,
-0.008015915,
0.017145906,
0.018137705,
0.011303798,
-0.034373328,
-0.0134436395,
0.019170264,
0.00007111577,
-0.008654471,
0.00075955887,
-0.021602212,
0.0062259203,
0.00071497884,
-0.0076490846,
-0.02787908,
0.0018562276,
-0.026072102,
-0.008375951,
0.026167206,
-0.0057741757,
0.0146731995,
0.00390606,
-0.00250837,
0.004925032,
-0.014088989,
-0.005763986,
0.0046057543,
0.0017050802,
-0.00598816,
0.012424667,
-0.005882866,
0.02164297,
-0.0099859275,
-0.0010631277,
-0.03334077,
-0.027593767,
-0.014252025,
0.026371,
0.014428646,
0.0029516227,
0.008477849,
0.022729874,
-0.026506864,
-0.011263039,
0.013715366,
-0.005587364,
-0.017526321,
0.0055941576,
0.0048910663,
-0.036547136,
0.0013323062,
-0.0024149641,
-0.014605268,
-0.01025086,
0.011487213,
0.18368672,
-0.009435683,
0.007214323,
0.004765393,
0.007343393,
-0.031982142,
0.0022298507,
0.0067014406,
-0.005645106,
0.008240089,
0.030514821,
0.015692173,
-0.023789605,
-0.0075607738,
0.035052642,
-0.025990585,
-0.01918385,
-0.017308941,
-0.012451841,
0.001456281,
0.017920325,
-0.00550245,
-0.006962977,
-0.026330242,
0.01025086,
0.004918239,
-0.038639426,
-0.014972098,
0.0016830025,
0.01815129,
-0.04287835,
0.010359551,
-0.007907224,
0.0101014115,
0.007193944,
0.01830074,
-0.005747003,
-0.0062259203,
-0.024903681,
-0.014374301,
0.0010919985,
-0.0050473087,
-0.0027682078,
-0.005699451,
-0.010597311,
0.026330242,
-0.0052341204,
-0.02013489,
-0.0047178413,
-0.013008879,
-0.037199277,
0.03323208,
0.010651656,
0.04673686,
-0.0053835697,
0.0059677805,
0.0021822988,
-0.013715366,
0.004208355,
0.032036487,
-0.028993156,
0.0006720971,
-0.027906252,
0.018626811,
-0.011901596,
0.026357414,
-0.022172835,
0.019632198,
0.024849335,
-0.0058556935,
-0.002058324,
-0.00904168,
-0.010257654,
-0.026099274,
-0.0007786646,
-0.005566985,
0.054236494,
0.022498906,
0.025515065,
0.008043087,
0.02431947,
-0.012832257,
0.00016813041,
-0.016086174,
-0.00586928,
-0.02391188,
0.025297683,
0.003177495,
-0.011643455,
-0.0076219123,
0.021724487,
-0.009102819,
-0.005882866,
-0.02479499,
-0.01381047,
-0.003851715,
-0.008375951,
-0.005206948,
-0.0029635108,
0.0037668005,
-0.033503804,
0.062823035,
0.03228104,
0.005101654,
-0.015651412,
-0.014075403,
0.025229752,
0.013416467,
0.000051160896,
-0.0084235035,
0.03334077,
-0.004137027,
0.014958512,
0.00012153367,
0.004170993,
0.02311029,
0.014360715,
-0.070268326,
0.029400745,
-0.0008916007,
-0.008559367,
-0.020528894,
-0.022430975,
0.045052156,
-0.01745839,
-0.003058615,
0.014265611,
-0.0056009507,
-0.013219466,
-0.0093201995,
0.003957009,
-0.020787032,
0.01955068,
-0.009401717,
0.025175406,
-0.015597068,
0.021670142,
-0.012642048,
-0.027186178,
-0.009157163,
0.0034101603,
0.003065408,
-0.0073569794,
0.021819592,
-0.004137027,
-0.01346402,
0.024088502,
0.02065117,
-0.005937211,
-0.007907224,
-0.009687029,
-0.01588238,
0.0042728903,
-0.0033829878,
-0.012954533,
-0.011052452,
-0.025107475,
-0.030677857,
0.010325585,
0.013294191,
-0.011269833,
0.018327914,
0.011657042,
0.0005638313,
0.017947497,
-0.02362657,
-0.17129602,
0.013993884,
0.028232323,
-0.016480178,
0.00915037,
0.032036487,
-0.0041098543,
0.022947254,
0.021276139,
-0.0008805618,
0.033802703,
0.008783541,
-0.037335142,
-0.020406617,
0.012784705,
0.032118004,
-0.01478189,
0.03869377,
0.005971177,
0.014754717,
0.01760784,
-0.032308213,
0.026656313,
-0.01849095,
0.00068865536,
0.006154592,
-0.013430053,
-0.009442476,
-0.011894803,
-0.034617882,
0.0008291886,
0.007214323,
0.010549759,
0.004072492,
0.01771653,
-0.0040011643,
-0.023898294,
0.009272647,
0.0038075594,
0.0019954871,
0.018368673,
0.003858508,
0.009951962,
0.0049080495,
-0.03377553,
0.023164636,
-0.018599639,
-0.021330485,
0.02043379,
-0.006514629,
0.00893299,
-0.0036954726,
0.009571546,
0.0041879755,
0.0236945,
0.013382502,
0.00080668635,
0.027634526,
0.004337425,
-0.004863894,
-0.004480081,
-0.022974426,
0.036329754,
-0.0055058463,
-0.0019275558,
-0.0141161615,
0.010162549,
0.022023385,
-0.02321898,
0.0063176276,
-0.019075159,
0.0135591235,
0.007914018,
-0.01588238,
0.0054990533,
0.011269833,
-0.0006682759,
-0.0049420153,
0.003957009,
-0.024659127,
0.000790128,
0.02762094,
-0.020746274,
-0.022444561,
0.0036241445,
-0.024414575,
-0.0015598766,
0.025365615,
-0.0025236544,
0.013233053,
0.02574603,
-0.016235624,
0.025800375,
-0.025841136,
0.029808333,
0.013484399,
0.003077296,
-0.025800375,
0.0045038573,
-0.00010725744,
-0.006321024,
-0.014197679,
-0.014333542,
-0.00003165713,
0.030596338,
0.0033914791,
-0.010801106,
-0.011657042,
0.03353098,
-0.007343393,
0.0029431314,
-0.007513222,
0.009924789,
0.027308455,
0.020202823,
0.026819348,
-0.01342326,
0.01944199,
0.01305643,
-0.024333056,
0.07928962,
-0.011813285,
-0.004235528,
-0.015610654,
-0.011398902,
-0.0040215435,
-0.13966712,
-0.028042115,
-0.0032216504,
0.032471247,
-0.014822649,
0.015950311,
-0.009802513,
0.03603086,
-0.0073162206,
0.04078606,
-0.02149352,
-0.014360715,
0.0007132805,
0.014550923,
-0.0010385026,
-0.0070784604,
-0.0030603132,
-0.027131833,
0.0046057543,
0.012207287,
-0.0053462074,
-0.018518122,
0.002905769,
-0.018803434,
0.004089475,
0.0042287344,
-0.024849335,
-0.004463098,
0.007995536,
0.00904168,
-0.018164877,
-0.02226794,
0.029156191,
-0.011127177,
-0.025705272,
-0.023653742,
-0.0059813666,
-0.051301856,
0.03363967,
-0.009911203,
-0.004130234,
-0.0011234168,
0.0035358334,
-0.006942597,
0.0071395985,
0.0035290404,
-0.003627541,
0.02248532,
-0.009136784,
-0.0051458096,
-0.041465376,
0.0030331407,
-0.020270754,
-0.019346885,
0.006062885,
-0.018395845,
0.003005968,
0.006178368,
-0.03660148,
-0.01815129,
-0.0043102526,
-0.0028616136,
-0.0069154245,
0.00035515428,
0.01504003,
-0.0115008,
-0.026425345,
-0.03605803,
0.028476877,
-0.018205637,
-0.010570139,
0.011161142,
-0.037769902,
-0.012010286,
-0.018463776,
0.032145176,
-0.03407443,
-0.02006696,
0.021099517,
-0.024400987,
-0.020854965,
-0.03793294,
0.019618612,
-0.022974426,
0.020800618,
-0.0032641075,
0.010773933,
0.009007715,
0.011874422,
-0.006011936,
-0.0076015326,
0.03344946,
-0.00378718,
-0.020189235,
0.00028127877,
0.0068916488,
-0.008443883,
-0.014496578,
0.028476877,
0.0073705656,
-0.013219466,
-0.015760103,
-0.05619292,
0.022050558,
-0.009265854,
0.0004988718,
0.013307777,
-0.030868065,
0.02548789,
-0.012268425,
0.0108826235,
0.033395115,
-0.039264396,
0.022077732,
-0.015529136,
0.002769906,
-0.020787032,
-0.017404046,
0.016167693,
0.012703187,
0.01221408,
0.022580424,
-0.00031014965,
-0.016629627,
0.03187345,
0.012764325,
-0.002177204,
0.007214323,
-0.0053767767,
0.03165607,
-0.0021296518,
-0.0029855885,
0.019971855,
-0.013749331,
-0.029645298,
0.004653306,
-0.011330971,
0.00027830678,
-0.018762674,
0.03722645,
0.025324855,
0.024835749,
-0.027770389,
-0.030949581,
0.006076471,
0.019455576,
-0.01247222,
0.01562424,
-0.038123146,
0.0114396615,
0.02039303,
-0.0067218198,
0.030895237,
-0.016955698,
0.011616283,
-0.027960597,
-0.024550436,
0.009863651,
-0.0019071763,
-0.012689601,
-0.004303459,
-0.045677125,
0.029753989,
0.025501478,
0.01672473,
-0.008015915,
0.016955698,
-0.017730117,
-0.018586053,
0.005325828,
-0.008396331,
-0.025365615,
-0.020895723,
0.04632927,
0.014727545,
0.0012533359,
-0.019306127,
-0.0073298067,
-0.021045173,
0.00804988,
0.0009094327,
-0.001822262,
0.001603183,
0.00781212,
-0.015936725,
0.015053616,
-0.004738221,
0.002751225,
-0.009788927,
0.024849335,
-0.03018875,
0.00891261,
0.038204666,
0.021588624,
0.018069774,
0.007961569,
0.006307438,
0.04507933,
-0.014618855,
0.015556309,
-0.006551991,
0.03062351,
-0.0071395985,
0.011568731,
0.0134436395,
-0.02986268,
0.0028429325,
0.03584065,
-0.005043912,
-0.014741131,
-0.0032861854,
0.013545537,
0.00537338,
0.0012626764,
-0.008301226,
0.0015225143,
-0.012227667,
0.0005302901,
-0.005183172,
-0.02457761,
-0.016493764,
0.02306953,
0.020895723,
0.012261632,
-0.029645298,
-0.008403124,
0.029536607,
0.00023712333,
0.032226693,
-0.024292298,
0.015325342,
0.0033880826,
0.04266097,
-0.005485467,
-0.018178465,
-0.009571546,
-0.0031724002,
-0.0042932695,
0.0006992697,
0.0036581103,
-0.018504536,
0.08418069,
0.045867335,
-0.01504003,
0.0019785045,
-0.016860593,
0.039590467,
0.012954533,
-0.0011641757,
-0.004313649,
-0.031085445,
0.024305884,
-0.017798048,
0.03480809,
-0.03124848,
-0.0057537965,
0.033069044,
-0.0173497,
0.0031740984,
-0.008613711,
-0.051193163,
0.015107961,
-0.050622538,
0.0050676884,
0.022444561,
-0.012159735,
0.0031486242,
0.017770875,
-0.016942112,
0.013103982,
0.003984181,
0.0109913135,
-0.0073365998,
-0.02714542,
0.003366005,
0.0014724148,
0.010869036,
0.02328691,
-0.005692658,
0.027580181,
0.018409431,
0.007024115,
0.0011208694,
-0.0029397348,
-0.020012613,
0.021194622,
-0.003289582,
0.00095953216,
0.00031842882,
-0.013158328
] |
Inhibitor-of-Apoptosis (IAP) proteins contribute to tumor progression, but the requirements of this pathway are not understood. Here, we show that intermolecular cooperation between XIAP and survivin stimulates tumor cell invasion and promotes metastasis. This pathway is independent of IAP inhibition of cell death. Instead, a survivin-XIAP complex activates NF-kappaB, which in turn leads to increased fibronectin gene expression, signaling by beta1 integrins, and activation of cell motility kinases FAK and Src. Therefore, IAPs are direct metastasis genes, and their antagonists could | [
-0.021089759,
-0.01599542,
0.006989595,
-0.02127794,
-0.03250162,
0.015605615,
-0.041803155,
0.0031318762,
0.006653557,
-0.016062627,
0.039007317,
-0.009079753,
0.038711604,
0.018845024,
-0.008400956,
-0.010739782,
0.04051277,
0.008763877,
-0.0067308457,
0.011936078,
-0.011364813,
0.032340318,
0.008306865,
-0.016452432,
-0.00949644,
0.039867576,
-0.0067207646,
-0.048577685,
0.0060722106,
-0.031614475,
0.00993329,
0.0016163439,
-0.016318016,
0.00948972,
0.009341863,
-0.011445462,
-0.010551601,
-0.021681186,
-0.001002234,
-0.0026160576,
0.009677901,
-0.006794693,
-0.007923782,
0.014705033,
-0.017890675,
-0.013071887,
-0.0040828646,
-0.012406532,
-0.013723802,
0.020095086,
0.0040828646,
-0.010927963,
-0.023119431,
-0.028603574,
-0.0038980434,
0.0006615753,
-0.001608783,
0.018764375,
0.009375467,
-0.0051817093,
-0.0042441627,
0.0056891274,
-0.028764872,
0.022729626,
0.0004691934,
0.012601433,
0.004798626,
-0.0009736708,
0.013300393,
0.013132374,
0.041749388,
0.04852392,
-0.032286555,
-0.007419724,
0.0048456714,
-0.019785931,
-0.024853388,
-0.0073256334,
-0.03102305,
0.018172948,
0.02699059,
-0.014073282,
0.010692736,
0.024248518,
0.037690047,
0.0017356374,
-0.01829392,
0.004368497,
0.013522179,
-0.0063679246,
0.023845272,
0.019046647,
0.0052959626,
0.028791755,
-0.024382934,
0.015968537,
-0.0035519241,
0.025364166,
0.01397919,
-0.036856674,
-0.0059277145,
0.0043012896,
-0.0067980536,
-0.01494698,
-0.011734455,
-0.0079842685,
0.0086765075,
0.0034712749,
0.04096978,
0.0011408498,
-0.029544482,
0.024275402,
0.01317942,
-0.03156071,
0.022218848,
-0.020511774,
0.023603326,
-0.00080985215,
-0.022743067,
-0.015955096,
0.02215164,
0.018616518,
0.022635534,
-0.01405984,
0.015390551,
0.015968537,
-0.0054169362,
0.0009677901,
-0.00993329,
-0.015094837,
0.028603574,
0.027219096,
0.017810026,
-0.0023354657,
-0.023415145,
0.004943122,
-0.015094837,
-0.021640861,
0.0023304252,
-0.030673569,
0.014745357,
0.027797082,
-0.00044273038,
-0.013327276,
-0.018361129,
0.010679295,
0.011203514,
-0.00272527,
0.0005750454,
0.019342361,
-0.015094837,
-0.028764872,
-0.0044189026,
-0.03701797,
-0.0014046398,
0.012077214,
-0.0009106636,
0.027743317,
-0.0033368596,
-0.012769453,
-0.006173022,
-0.0016230646,
0.0033620624,
0.010101309,
0.008434559,
0.02900682,
0.0009619094,
0.009301539,
-0.010672574,
-0.020202618,
0.014705033,
0.014355553,
-0.04070095,
0.009046149,
-0.019678399,
0.008064917,
-0.0015650981,
0.014597501,
-0.021909693,
-0.017178275,
0.00037027212,
0.017998207,
0.023401702,
0.001985986,
-0.0188047,
-0.0075810226,
0.02205755,
-0.0081186835,
-0.0013424727,
-0.018307364,
0.008038035,
0.012675362,
0.011324489,
-0.01635834,
-0.6288485,
-0.04341614,
0.03400707,
-0.011243839,
0.014019515,
0.049088463,
0.017608404,
-0.0145437345,
-0.0146781495,
0.011653806,
-0.024934037,
0.03970628,
-0.0067913327,
-0.014866332,
-0.01829392,
-0.037125506,
-0.0078095286,
-0.024127545,
-0.002075036,
0.005413576,
0.00024656806,
0.022904366,
0.000048515518,
0.029920844,
-0.01853587,
0.022191964,
0.049437944,
-0.015619057,
0.008058197,
0.026587345,
-0.01696321,
0.044787176,
0.0014214417,
-0.0026614228,
0.053309105,
0.0025975755,
-0.009603973,
0.024705531,
0.029786428,
0.048738986,
-0.02188281,
-0.0036191319,
-0.0033788644,
0.0054202965,
-0.008313586,
0.005369891,
0.01405984,
0.0018952556,
0.0045936424,
-0.017433664,
0.0040156567,
0.024235077,
-0.05968039,
0.0009921528,
0.0016054227,
0.014422761,
0.020619307,
-0.03131876,
0.028334744,
0.025686763,
0.008763877,
0.017984767,
-0.011989844,
-0.0027521532,
-0.036426544,
0.011008613,
-0.007843132,
0.004516354,
-0.001713795,
0.02275651,
0.03129188,
0.039760042,
-0.009328421,
0.005054015,
0.029221885,
0.04024394,
-0.0058907503,
0.036534075,
-0.011109424,
0.0065359436,
0.008313586,
-0.017594961,
-0.028845523,
0.013441529,
0.013555782,
0.02707124,
-0.019880021,
0.017447105,
0.0068417382,
0.010403744,
0.015350226,
-0.007923782,
-0.015054513,
-0.03250162,
-0.0048221485,
0.023186637,
-0.012944193,
0.010007218,
0.0010761624,
-0.033738237,
-0.0030965924,
0.0077490415,
0.0012660241,
-0.010612087,
0.023226963,
0.0024043536,
-0.026654553,
0.001969184,
0.014395878,
-0.028684223,
0.009368746,
-0.009173844,
0.006425051,
-0.03263603,
-0.01010803,
-0.017285807,
0.027044358,
0.007003037,
0.009852641,
-0.034571614,
0.0089789415,
-0.008038035,
0.010114751,
-0.0033200576,
0.022837158,
0.01326679,
0.014368995,
-0.021950018,
-0.019181062,
-0.0034880769,
-0.003402387,
-0.012325882,
0.0028462438,
-0.020189177,
0.015941653,
-0.016102953,
-0.003498158,
0.0054471795,
-0.0037804302,
-0.030619804,
-0.04457211,
-0.01230572,
0.014288345,
-0.0005338807,
-0.018912232,
-0.0010190359,
-0.009832479,
0.0015701386,
0.028146563,
0.004348335,
-0.018482102,
0.020941902,
0.012816498,
-0.0018868546,
0.03930303,
-0.008387514,
0.014879772,
-0.006216707,
-0.035862,
-0.008817643,
-0.0026362198,
0.01194952,
-0.008925175,
-0.02707124,
-0.0026580624,
-0.013206302,
0.027635785,
-0.005991562,
0.0052657193,
-0.026788969,
-0.011747897,
-0.011707572,
-0.039356798,
0.008044755,
0.0016507878,
0.001696993,
0.008602579,
0.000228506,
0.004361776,
-0.0056387214,
0.011768059,
-0.033281226,
-0.012144421,
0.005151466,
0.035512522,
0.028496042,
0.0326898,
0.0033973465,
0.004694454,
0.035082392,
-0.0154712,
0.021869369,
-0.0032629312,
0.025256634,
-0.01168741,
-0.0051178625,
0.010302932,
0.018912232,
-0.0029403346,
0.030216558,
0.02207099,
-0.020632748,
0.016035745,
0.0002971838,
0.021331707,
-0.013858217,
0.00012118379,
-0.02513566,
0.01854931,
-0.014127047,
0.009321701,
0.02031015,
0.00043306928,
-0.008192612,
0.008098521,
-0.005037213,
0.0035552846,
-0.0013945587,
-0.020995669,
-0.01608951,
-0.026157215,
-0.01107582,
0.013844775,
-0.0065258625,
0.0012282197,
-0.008152287,
0.021398915,
0.025014685,
0.0053833323,
-0.022998456,
0.003948449,
0.0068787024,
0.009792154,
0.0023623488,
0.017366456,
-0.0044625876,
0.0011240479,
0.0002101289,
0.045808733,
-0.0076683923,
0.010558321,
0.0007359237,
0.0058941105,
0.016452432,
0.010060985,
-0.0030428262,
0.030001493,
0.0146781495,
-0.02215164,
0.006609872,
0.009167123,
0.023831831,
-0.00020540337,
0.0044525065,
0.0064888983,
-0.02337482,
0.0108002685,
0.017299248,
0.055056505,
0.0089117335,
0.02583462,
-0.035620052,
-0.004143351,
-0.011667247,
-0.0013542341,
0.002152325,
-0.007426445,
-0.0062704734,
0.0046541295,
-0.018791258,
-0.015928213,
-0.0091133565,
0.035727583,
-0.01432867,
0.022971574,
-0.008602579,
0.014315229,
0.024624882,
0.0050708167,
-0.0098391995,
0.006015084,
-0.047690544,
0.050405733,
0.0014365634,
-0.014651267,
-0.003525041,
-0.023845272,
-0.009200727,
0.008952059,
0.016667496,
0.014113606,
0.011371533,
0.008535371,
-0.0023707498,
-0.007251705,
-0.0005742053,
0.02830786,
-0.02943695,
0.01985314,
-0.001607943,
0.014610942,
0.0070635234,
-0.008501767,
-0.0050842585,
0.045728084,
0.0033671032,
0.01151939,
-0.0155384075,
-0.021640861,
-0.028549809,
-0.015256136,
0.0027000671,
0.012937472,
-0.007688555,
0.003840917,
-0.013011401,
0.000026082342,
-0.013502016,
0.023052223,
0.013690198,
-0.006861901,
-0.03172201,
0.007507094,
-0.002574053,
0.024208194,
0.034679145,
-0.0071441727,
0.008784039,
-0.0014525253,
0.0010971648,
-0.0022531364,
-0.0014617663,
0.021681186,
-0.026614228,
0.0060755713,
-0.003296535,
0.0018902151,
0.0038442775,
0.024772739,
0.02811968,
-0.0115261115,
-0.02989396,
-0.016102953,
-0.01643899,
-0.018253596,
-0.017326131,
0.029840196,
0.013764126,
0.019772489,
-0.0055009457,
0.0022111316,
0.016035745,
0.00079683063,
-0.02434261,
0.012796336,
0.008132125,
0.023388261,
0.009778713,
-0.011364813,
-0.03129188,
0.009603973,
0.014449644,
0.00535981,
0.008421118,
0.010134913,
0.009987056,
0.007856574,
-0.015094837,
0.02302534,
-0.015121721,
0.0035821674,
0.002847924,
0.0077557624,
-0.009039428,
0.005759695,
-0.009032708,
-0.026237866,
-0.027111564,
-0.0022380147,
-0.0039047643,
0.002268258,
0.0053329268,
0.007661672,
-0.012648479,
-0.014691591,
-0.017057301,
0.0108338725,
-0.012433414,
0.0031940434,
-0.020552099,
-0.010793548,
-0.020498332,
-0.011203514,
-0.012460298,
0.026331956,
-0.044840943,
-0.010753224,
-0.006257032,
0.0021926495,
0.0022968212,
0.0052758004,
-0.015121721,
-0.014920098,
0.029544482,
-0.0036493752,
-0.014664709,
0.0014735276,
-0.024382934,
0.014785682,
-0.0050876187,
-0.010914521,
-0.02012197,
0.0035989694,
-0.011983124,
0.002189289,
-0.004166874,
0.0051380247,
-0.018495545,
-0.0022917807,
0.0060789315,
0.012144421,
0.017904118,
0.0018095659,
0.01309877,
0.015067955,
-0.028845523,
-0.025780853,
-0.028280977,
-0.014073282,
-0.008111963,
0.010585205,
0.011143028,
-0.017944442,
-0.004983447,
-0.0013349119,
0.020699956,
0.0076347888,
-0.016896002,
0.017164832,
0.035512522,
-0.0014609263,
0.005816822,
-0.014826007,
0.008468163,
-0.015524967,
0.004533156,
-0.00047045352,
0.011647085,
-0.012641759,
-0.004734779,
0.0011206875,
-0.012265395,
-0.015067955,
0.0010786827,
-0.021963459,
0.02768955,
0.021640861,
-0.020444566,
-0.009664459,
0.005968039,
-0.010309653,
-0.0031570792,
-0.0048826355,
-0.022635534,
0.0006880383,
-0.0012130981,
0.012944193,
-0.028442277,
0.02496092,
-0.037125506,
0.0004448306,
0.025444815,
0.008757156,
-0.007191218,
-0.016304575,
-0.0074667693,
-0.03075422,
-0.0024362772,
-0.043201074,
-0.044491462,
-0.021210734,
-0.0033419002,
0.035082392,
0.027501369,
0.021506447,
0.021667745,
0.024665207,
0.005853786,
0.02707124,
-0.0011610121,
-0.0008947018,
0.0013029883,
-0.006337681,
0.039034203,
-0.0020229502,
0.01318614,
0.043120425,
-0.021466123,
0.032420967,
0.006821576,
-0.023079107,
-0.025068453,
0.009274655,
-0.02453079,
-0.027165331,
0.0028899289,
-0.011304326,
-0.0040156567,
-0.03454473,
0.013844775,
0.004519714,
0.0038442775,
0.009765271,
-0.0039753322,
0.035620052,
-0.017971324,
0.027286304,
0.0067913327,
-0.00052001915,
-0.012500622,
-0.0027235898,
0.016922886,
-0.003911485,
0.025565788,
-0.015175487,
0.0033822248,
-0.005544631,
-0.03578135,
0.010867476,
-0.00048809554,
-0.011815105,
-0.010712899,
0.0055513517,
-0.0052354755,
-0.0034947975,
-0.026923383,
-0.02408722,
-0.038577188,
0.0098391995,
0.015000747,
-0.023186637,
0.011035495,
0.013407925,
-0.016600288,
0.04244835,
-0.000571265,
0.0019389406,
-0.011176632,
0.038577188,
0.013817892,
-0.003612411,
-0.019745607,
-0.020955345,
-0.010759944,
0.016586848,
0.019732164,
0.035297457,
-0.00060654903,
-0.02549858,
-0.006401528,
-0.0028143201,
-0.025028128,
-0.03250162,
0.014960422,
-0.003918206,
0.019906905,
-0.013831333,
-0.030270323,
-0.030189674,
0.012211629,
-0.017379897,
0.0012609834,
0.004365137,
-0.001644067,
-0.0115597155,
0.00606549,
0.012467018,
0.004136631,
0.012137701,
-0.024826504,
-0.0067274855,
-0.030727336,
0.013791009,
-0.00861602,
0.0081186835,
0.02434261,
0.0003209165,
0.013898541,
0.0048792753,
0.021748394,
0.0005372411,
-0.0051985113,
0.004227361,
0.04016329,
-0.0017389979,
0.005369891,
-0.020202618,
-0.0006317519,
0.002673184,
-0.022245731,
0.0071844975,
-0.0076347888,
-0.02857669,
0.0012198188,
0.016022302,
0.014288345,
-0.0058605066,
0.0074062827,
-0.02707124,
-0.0050977,
-0.019839697,
-0.021035993,
0.018912232,
-0.03225967,
-0.028092796,
-0.010363419,
0.019557426,
0.01116319,
0.0146781495,
0.009335142,
-0.011929357,
0.03892667,
-0.029141236,
0.030243441,
0.007244984,
0.001029117,
-0.00536317,
0.027931498,
-0.019194504,
-0.027770199,
0.03121123,
-0.006582989,
-0.0077154376,
-0.004318091,
0.012796336,
0.022165082,
0.00078716956,
-0.018482102,
0.011989844,
0.009651018,
-0.00448275,
0.0011786541,
0.010827152,
0.0072718672,
-0.013293672,
0.018253596,
0.017635286,
-0.0028092796,
-0.023966247,
-0.0136834765,
0.0061931848,
0.0063309604,
-0.022353264,
-0.021210734,
-0.011552994,
0.0059008314,
0.0001239141,
-0.015699707,
0.0013920384,
-0.005571514,
-0.021143526,
0.005195151,
0.0065225023,
-0.009449395,
-0.008918455,
0.013300393,
-0.01635834,
0.0048221485,
-0.01678847,
-0.0023102628,
-0.0071307314,
-0.027366953,
-0.019140737,
0.018441778,
-0.027030915,
0.022124758,
0.002365709,
-0.0063007167,
-0.022165082,
-0.010578483,
-0.04183004,
-0.021829043,
-0.009382187,
0.012366207,
-0.010847314,
0.003938368,
-0.020901578,
0.016855678,
-0.00010868737,
-0.0012719047,
-0.00088126026,
-0.024208194,
0.00037867308,
-0.008340469,
0.006015084,
-0.002479962,
-0.021654304,
-0.030377856,
0.024638323,
-0.0046978146,
-0.008300144,
0.025552347,
-0.0086093,
-0.0009081433,
-0.00606549,
0.0021304823,
0.007486932,
0.011680689,
0.024208194,
-0.020673072,
-0.011479066,
0.01943645,
-0.0010845634,
-0.0058672274,
0.010679295,
-0.00029382342,
0.030431623,
-0.019033205,
0.005201872,
-0.035566285,
0.000711981,
-0.0025337283,
0.025592672,
0.012070493,
0.014221138,
0.015632499,
0.023442026,
-0.011721013,
-0.019503659,
-0.0031369168,
-0.011384975,
-0.010907801,
0.010242445,
0.0034040674,
-0.017097626,
-0.018939115,
0.0038476377,
-0.012151143,
-0.016882561,
-0.005574874,
-0.014584059,
-0.0079842685,
0.006136058,
0.009005825,
0.023347937,
-0.020968786,
0.003736745,
-0.021345148,
-0.021479564,
0.006468736,
-0.0228506,
0.0037501866,
-0.0029252127,
-0.0048994375,
0.010571763,
0.002064955,
-0.020538656,
-0.026184099,
-0.0077557624,
0.022030666,
0.20377359,
-0.024597999,
0.00536317,
-0.0017163153,
-0.0067274855,
0.001150931,
0.022124758,
-0.004254244,
-0.0015508165,
-0.0048994375,
0.012856822,
0.019060088,
0.008898293,
-0.0047952654,
0.026883058,
-0.012782894,
-0.023240404,
0.0070635234,
-0.03164136,
0.0057361727,
0.009267935,
-0.015780356,
0.009684621,
0.013656594,
0.032985512,
0.0057529747,
-0.036964204,
0.012366207,
0.0145437345,
-0.0036863394,
-0.018132623,
0.008515209,
0.0045566782,
-0.0028227211,
0.00084681634,
0.007890178,
-0.021560213,
-0.010921243,
-0.0020263104,
-0.011203514,
-0.016049186,
0.008367352,
-0.013757405,
-0.0023489073,
-0.0039417283,
0.006539304,
0.0011593319,
-0.033442523,
0.009966894,
0.009180564,
-0.039894458,
-0.0037636282,
0.026614228,
0.021761836,
-0.011432021,
0.0028092796,
0.0027387117,
-0.006458655,
-0.0069223875,
0.023764623,
0.0052758004,
0.00079347024,
-0.043819387,
0.030512271,
-0.015484641,
0.035109274,
0.00298906,
0.014570618,
0.012991238,
-0.021089759,
-0.007399562,
-0.000931666,
-0.024759296,
0.004516354,
0.004314731,
-0.019355802,
0.011351371,
0.022191964,
0.011297605,
0.025995918,
0.013602828,
0.008918455,
-0.022460796,
0.023845272,
-0.011862149,
-0.03454473,
0.017756261,
0.0013953988,
-0.019221386,
-0.021035993,
0.006213347,
-0.013260068,
-0.007567581,
-0.01897944,
0.008145567,
-0.0033469407,
-0.0017557997,
0.003612411,
-0.013125653,
-0.011331209,
-0.013159257,
0.06849803,
0.01116991,
0.009570369,
-0.018038532,
-0.0055009457,
-0.00096022926,
0.0040727835,
0.0031352367,
0.007708717,
-0.0032847738,
-0.021842485,
-0.006159581,
-0.010054264,
-0.005037213,
0.019086972,
0.0071508936,
-0.017070742,
0.020458007,
-0.007110569,
-0.013333997,
-0.037394334,
0.012070493,
0.022097874,
0.0053228457,
0.012735849,
-0.0309424,
0.0019893462,
-0.023495793,
-0.017312689,
0.011539553,
0.009819037,
-0.008857967,
-0.014086722,
0.003709862,
0.010464231,
0.013018121,
-0.019880021,
0.008098521,
0.017003534,
-0.02830786,
0.008091801,
-0.000536401,
0.037851345,
-0.0035384826,
0.0048927166,
0.014637825,
0.002241375,
-0.011586598,
-0.015188928,
-0.0132466275,
-0.015847564,
-0.00035473035,
-0.005158187,
0.036722258,
-0.007843132,
-0.0065594665,
-0.029356299,
0.014073282,
0.00914024,
-0.033173695,
0.017205158,
0.014570618,
-0.02091502,
-0.016102953,
-0.0019423009,
-0.17000847,
0.0071576145,
-0.005991562,
-0.027850848,
0.036399662,
0.00597812,
-0.017379897,
-0.014933539,
0.004200478,
-0.012258675,
0.00948972,
-0.0038543586,
-0.020511774,
-0.00140632,
0.018038532,
0.01942301,
-0.0010475991,
0.040405236,
0.00008064917,
0.0033334992,
0.009120078,
-0.016331458,
0.025162542,
-0.019638075,
-0.014221138,
0.023119431,
-0.00043852988,
-0.048658337,
-0.0042643254,
-0.0035821674,
-0.0041097477,
-0.0026126972,
0.01985314,
0.0011887352,
0.03016279,
-0.0026446208,
-0.025202867,
0.00093670655,
-0.000870339,
0.036345895,
0.036372777,
0.020632748,
-0.002081757,
0.00023060624,
-0.00641497,
0.021761836,
-0.0070702443,
0.016210483,
0.02742072,
-0.002663103,
0.010094589,
-0.023616767,
-0.002663103,
0.014449644,
0.017635286,
0.0077288793,
0.013965749,
-0.004106387,
0.013239906,
0.0017104346,
-0.0038005924,
0.002864726,
0.03527057,
0.0020884776,
0.0028966495,
-0.05591676,
-0.0061192564,
0.03524369,
-0.036453426,
0.00492296,
-0.022729626,
0.022823717,
0.027125007,
-0.020256385,
0.0114925075,
0.0077557624,
0.010517997,
0.0044592274,
-0.014100164,
-0.0017473988,
-0.037367452,
0.012534226,
-0.014557176,
-0.028899288,
-0.004526435,
0.01002066,
0.018737491,
0.005373251,
0.0063309604,
-0.012668641,
0.019476775,
-0.015968537,
-0.010222283,
-0.020014437,
0.03691044,
0.025310399,
0.00063763256,
-0.0077759246,
-0.00032280674,
0.007244984,
0.012097376,
-0.025592672,
0.001819647,
-0.0030176232,
0.019678399,
-0.0021388833,
0.0025219668,
-0.008555533,
0.04333549,
-0.03306616,
-0.020592423,
-0.0032914944,
-0.002073356,
0.01362299,
-0.0024161148,
0.023966247,
-0.0062368694,
0.0013777567,
-0.010598646,
-0.02873799,
0.08086424,
0.0060621295,
-0.0022816996,
0.011223677,
0.006485538,
-0.016546523,
-0.123339474,
-0.02943695,
0.027823966,
0.015363668,
-0.022648977,
0.022165082,
-0.0019456614,
0.023307612,
-0.024382934,
0.014530293,
-0.023603326,
-0.019275153,
-0.01582068,
-0.01080699,
0.00032154657,
-0.0011307687,
0.0052758004,
-0.01160004,
-0.019812815,
0.042260166,
0.01362299,
0.0007145013,
-0.006246951,
-0.010276049,
-0.009859362,
-0.0016566685,
-0.015713148,
0.0145437345,
0.0028227211,
0.0135826655,
0.0015684584,
-0.0006829977,
0.032904863,
-0.0020867975,
-0.020229502,
-0.010161796,
0.001344153,
-0.028415393,
0.033603825,
-0.013925424,
-0.00041185686,
0.008320306,
0.011109424,
-0.0035989694,
-0.009812316,
-0.019611191,
-0.030001493,
0.012614875,
0.032582268,
-0.0066838004,
-0.028065912,
-0.02012197,
-0.019960672,
-0.014960422,
0.007218101,
-0.018038532,
0.018562753,
0.035082392,
-0.0061226166,
0.014261463,
-0.004146712,
-0.0063175187,
-0.009267935,
-0.0035989694,
0.025538906,
-0.016170159,
-0.011815105,
-0.028953055,
0.02346891,
0.0126888035,
-0.005134664,
-0.011190073,
-0.022689302,
-0.008273262,
-0.029221885,
-0.0071777767,
-0.009879524,
-0.004734779,
0.010276049,
-0.024450142,
-0.024759296,
-0.027662667,
0.013340718,
-0.02083437,
0.042206403,
-0.0071038483,
0.0066569173,
-0.015000747,
0.007433166,
-0.00039841532,
-0.0062939962,
0.04720665,
0.018172948,
-0.022178523,
-0.015081395,
-0.003945089,
0.014705033,
-0.0021556853,
0.002970578,
0.025807736,
-0.031264998,
0.0022985016,
-0.048980933,
0.01405984,
0.0058672274,
0.024544232,
0.018065415,
-0.010229004,
-0.005961318,
-0.021493005,
0.017124508,
0.013421367,
-0.016936326,
0.03260915,
-0.0075541395,
0.009456116,
-0.004963285,
-0.0046642106,
0.035512522,
-0.015874445,
0.006670359,
0.037851345,
0.0007094607,
-0.0015432555,
0.0042374423,
-0.021412356,
0.02592871,
-0.018522426,
0.0010669214,
0.016156718,
0.00031461578,
0.011835267,
0.010235725,
-0.029759545,
-0.032797333,
0.0008644583,
-0.03260915,
-0.027434161,
-0.022608653,
0.017111067,
0.023253845,
0.039410565,
-0.009241051,
-0.020726837,
0.011976402,
-0.015430875,
0.0036964205,
-0.000545222,
-0.02083437,
0.0115261115,
-0.007863294,
-0.038604073,
0.027098123,
0.0027471127,
-0.012406532,
-0.019261712,
-0.029302534,
-0.014570618,
0.01432867,
-0.027125007,
-0.025189426,
-0.022985015,
0.016210483,
0.011889033,
0.0053329268,
0.015148603,
0.01204361,
-0.021022553,
-0.034652263,
-0.010954847,
0.0061494997,
-0.020148853,
-0.019745607,
-0.005158187,
-0.0019523822,
0.00049061584,
0.0035989694,
0.025982477,
-0.011633644,
-0.00914696,
-0.0046810126,
0.0011584918,
0.02857669,
-0.016667496,
-0.03199084,
0.03403395,
0.020189177,
-0.000088892615,
-0.024678648,
0.02927565,
-0.009610693,
-0.010686016,
-0.006882063,
0.011358093,
0.0016843916,
-0.010094589,
0.0071172896,
0.017111067,
-0.010739782,
0.028361626,
-0.008219495,
0.012789615,
0.011700851,
-0.015753472,
0.0004095466,
0.007446607,
-0.019503659,
0.019449893,
-0.014422761,
-0.047851846,
-0.016116394,
-0.01186887,
0.008952059,
0.022541445,
0.009832479,
-0.012265395,
-0.012151143,
0.022528004,
0.01529646,
-0.0040492606,
-0.013925424,
0.013676756,
0.024638323,
0.0107666645,
-0.0035015184,
-0.029329417,
-0.0002889929,
0.011593319,
0.0228506,
-0.027057799,
0.020794045,
-0.014355553,
0.037474982,
0.0007510455,
-0.04051277,
-0.0010139954,
-0.0050708167,
0.003719943,
0.012735849,
0.008306865,
-0.0077356,
0.08199333,
0.008333748,
-0.02435605,
-0.00457012,
-0.01002066,
-0.000076396194,
0.006216707,
0.009462836,
-0.019933788,
-0.054868322,
0.0056723254,
-0.0134818535,
0.0125879925,
-0.027205655,
-0.013938866,
0.01643899,
-0.016331458,
0.0036527356,
0.0037233036,
-0.0054270173,
0.006848459,
-0.0012525825,
-0.000046730318,
0.020175735,
-0.036077064,
0.014355553,
0.018320804,
0.01125056,
0.001335752,
-0.031937074,
-0.0073793996,
-0.007594464,
-0.021788718,
-0.008636182,
0.027931498,
0.0022228928,
-0.008562254,
-0.042502116,
0.008797481,
0.032662917,
-0.0056723254,
0.010894359,
-0.015094837,
-0.029867077,
0.02363021,
0.025108777,
-0.024033455,
-0.002073356,
0.004946483
] |
Prostaglandin E2 (PGE2) can stimulate tumor progression by modulating several proneoplastic pathways, including proliferation, angiogenesis, cell migration, invasion, and apoptosis. Although steady-state tissue levels of PGE2 stem from relative rates of biosynthesis and breakdown, most reports examining PGE2 have focused solely on the cyclooxygenase-dependent formation of this bioactive lipid. Enzymatic degradation of PGE2 involves the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). The present study examined a range of normal tissues in the human and mouse and | [
-0.0092219785,
-0.025787504,
0.015721215,
-0.030421402,
-0.0119447205,
0.01004011,
-0.023889441,
0.011146224,
-0.027515398,
-0.018208334,
0.007559535,
0.011826909,
0.011794184,
0.009064897,
-0.014543106,
0.015171431,
0.047386177,
0.010589894,
-0.014071862,
-0.00436555,
-0.01645426,
0.00750063,
-0.008574018,
-0.021952104,
0.00757917,
0.02756776,
0.009261249,
-0.048250124,
-0.0005726921,
-0.0050233277,
0.002668745,
0.005615655,
-0.0135613475,
0.009889574,
0.0038648532,
-0.018051254,
0.015825937,
-0.005173864,
0.0041332003,
-0.0028029187,
0.00812241,
0.0015061802,
-0.0051051406,
-0.0090190815,
-0.013168645,
-0.011139679,
-0.00011433388,
-0.012029806,
-0.02263279,
0.028614968,
-0.010216827,
0.0042837365,
0.008881636,
-0.005327672,
-0.011100409,
-0.0018342509,
-0.0005808734,
0.015210701,
0.002557479,
-0.023352746,
-0.015839025,
-0.0066824984,
-0.03159951,
-0.00009674405,
-0.008718009,
0.02120597,
0.008456207,
0.023378925,
0.007062111,
-0.0150143495,
0.029923977,
0.016820785,
-0.017187307,
-0.011165859,
-0.008600199,
-0.008927451,
-0.028326986,
-0.026036218,
-0.004944787,
0.008371121,
0.02890295,
-0.03159951,
0.017239667,
0.032227837,
-0.00884891,
0.0043262793,
-0.017069496,
0.00594618,
0.004113565,
-0.012972293,
0.0150143495,
0.016585162,
0.0020976893,
0.037359156,
-0.017278938,
0.016886234,
0.0175931,
0.029793078,
0.01133603,
-0.044741977,
0.018339235,
-0.008423482,
0.0003147761,
-0.015760485,
-0.036573753,
-0.017043315,
-0.007402454,
-0.013862421,
0.021781933,
0.0017933443,
-0.023274206,
0.023549097,
0.0009743946,
-0.014320574,
0.027881922,
0.0087311,
0.034453154,
0.018260695,
-0.007880243,
-0.012664676,
0.016009197,
0.0014701823,
0.041652713,
-0.010275732,
0.03390337,
-0.007153742,
0.0156034045,
0.005281857,
-0.020459833,
0.007814792,
-0.0034786952,
0.012088711,
0.0001987037,
-0.0050429627,
-0.028457886,
0.0063617905,
-0.0065155993,
-0.024413044,
-0.017252758,
-0.04290936,
0.018640308,
0.013718429,
-0.014556196,
0.0028110999,
-0.013993321,
0.025578063,
0.013574438,
0.0017655278,
0.0021745935,
0.032018393,
0.0021991376,
-0.008914361,
0.012429054,
-0.012494504,
-0.019975498,
-0.002979635,
0.01756692,
0.025211541,
-0.019268634,
-0.016977865,
0.021533221,
-0.017161127,
0.011414571,
0.013862421,
0.012291607,
0.02254116,
0.007389364,
0.036023967,
-0.005386578,
-0.022986222,
-0.0010954781,
0.01883666,
-0.034217533,
0.026729994,
-0.0069704806,
0.009634317,
-0.017344387,
0.021546312,
0.0043131895,
-0.033536848,
-0.006368336,
0.00068395794,
0.0046011717,
0.015642675,
-0.023496738,
-0.003452515,
0.018365417,
-0.003943394,
-0.0107666105,
-0.010550624,
-0.014268214,
0.0060934434,
-0.00064182415,
-0.010904057,
-0.6434048,
-0.03605015,
-0.0033641567,
-0.005808734,
-0.018522497,
0.036652293,
-0.0040906575,
0.008829275,
-0.018574858,
0.008718009,
-0.0057989163,
0.03508148,
0.008763825,
0.004853156,
-0.012193432,
-0.029426554,
-0.031023547,
-0.019006832,
0.0052720397,
0.00013448036,
0.0014325483,
-0.00026650634,
-0.01742293,
0.02395489,
0.021991376,
0.031704232,
0.021520132,
-0.009293974,
0.015184521,
0.058748387,
-0.01886284,
0.04029134,
-0.023666909,
0.00016199004,
0.045841545,
0.010845152,
-0.005455301,
0.029478915,
0.0016223548,
0.040579323,
-0.012324333,
-0.017344387,
0.0017475289,
-0.016048469,
-0.035605084,
0.020512193,
0.03895615,
-0.007389364,
-0.007003206,
-0.0013540076,
0.003570326,
0.0015454504,
0.012631951,
-0.023496738,
0.011329485,
0.01884975,
0.01326682,
-0.01758001,
0.0022007737,
-0.00036713653,
0.029243292,
0.016140098,
0.006754494,
-0.008803095,
-0.01756692,
0.02895531,
-0.014451475,
-0.014713277,
-0.015629584,
0.022829141,
0.021821205,
0.021114338,
0.007847518,
-0.009955024,
0.030971186,
0.046862572,
0.004306644,
0.010616074,
0.002060055,
-0.011205129,
0.027227417,
-0.008266401,
-0.050920505,
0.035500363,
0.01761928,
-0.005618927,
-0.036259588,
0.0018538861,
0.0072191926,
0.0048040682,
0.020263482,
0.012141071,
-0.035500363,
-0.024779567,
-0.013901691,
0.029976338,
-0.0073239133,
0.02148086,
0.0075399,
-0.016179368,
-0.02510682,
0.0054291207,
0.0033641567,
0.014948899,
0.025708964,
0.014255123,
-0.061942372,
-0.008652559,
0.028405527,
-0.029400375,
0.02263279,
-0.011205129,
0.002028966,
-0.017789451,
-0.010301912,
-0.022318628,
-0.0020322388,
-0.0016460806,
-0.015289241,
-0.024989009,
0.013279911,
-0.013260275,
-0.006446876,
-0.010799336,
0.02375854,
0.012671221,
0.006207982,
-0.019464985,
0.009293974,
0.015930656,
0.0032954337,
0.007677346,
0.018286876,
-0.009005992,
0.0077558868,
0.0040153894,
0.012278518,
-0.0046240794,
0.0019193365,
-0.020564554,
-0.034714956,
-0.0030778109,
0.0093332445,
0.0018407959,
0.0053211274,
-0.01382315,
-0.012206522,
0.010838606,
0.01254032,
0.004853156,
-0.011106953,
-0.006083626,
-0.0074744495,
0.027201237,
0.03128535,
-0.00047328908,
-0.007696981,
-0.0010529353,
0.00013366224,
-0.0011862906,
0.001250923,
-0.011100409,
-0.01742293,
0.020551464,
-0.034138992,
-0.01002702,
-0.016846964,
0.002537844,
0.0037535874,
-0.039401215,
-0.022449529,
0.006139259,
-0.0007011387,
0.006054173,
0.020184942,
0.0019651519,
-0.00042092867,
-0.015799755,
0.00467644,
-0.0025182087,
0.0038517632,
-0.017226577,
-0.015917568,
0.021755753,
0.032096937,
0.02382399,
0.0040841126,
0.0021418682,
0.010845152,
0.013574438,
0.014988169,
0.029138573,
0.011768004,
0.014268214,
0.008567473,
-0.047307637,
0.0028945494,
0.0075660804,
0.002930547,
0.03885143,
0.027122695,
-0.026468191,
0.013325726,
-0.0007641348,
0.012959203,
-0.020342022,
-0.022514978,
-0.026860895,
0.014948899,
0.014909629,
-0.0069508455,
0.005206589,
-0.01742293,
0.0016820783,
-0.008920906,
0.00822713,
-0.00038390822,
0.0012141071,
0.014019501,
-0.02514609,
-0.012160707,
-0.027305957,
0.009948479,
0.0043131895,
-0.028562607,
0.015590314,
0.018601038,
-0.0064796014,
-0.011885814,
-0.009339789,
-0.00869183,
0.021114338,
-0.00594618,
-0.00053423987,
0.005501116,
0.011198584,
0.018548677,
0.0034001546,
0.030866466,
0.021991376,
-0.006021448,
-0.0020355112,
0.02398107,
-0.013757699,
-0.0016804421,
0.007651166,
0.02378472,
-0.005792371,
-0.020472923,
0.02879823,
0.01882357,
0.01761928,
-0.0017491651,
0.006345428,
-0.0013850967,
0.0023104034,
0.013744609,
0.016558982,
0.049428232,
0.01382315,
0.01899374,
-0.0142420335,
0.005468391,
-0.012730126,
-0.002145141,
0.022226997,
0.016833873,
-0.012802122,
-0.0113556655,
-0.016585162,
-0.0029452734,
0.013417357,
0.0135613475,
-0.034898218,
0.014438385,
0.010210281,
0.023732359,
0.005131321,
-0.00055673847,
0.007978419,
0.0022040464,
-0.028457886,
0.02250189,
0.0076053506,
-0.0101055605,
-0.0144252945,
-0.007441724,
-0.0037470423,
0.013613708,
-0.003452515,
-0.0051967716,
0.008456207,
0.004866246,
0.0043393695,
-0.031913675,
-0.009830669,
-0.0035637808,
0.0025983858,
0.013666069,
-0.015367783,
0.0069704806,
0.015760485,
-0.017750181,
0.0003029132,
0.038537268,
0.0073631834,
-0.010269186,
-0.013744609,
-0.0052654943,
-0.02260661,
-0.0065515973,
-0.013954051,
0.006443604,
-0.019792238,
-0.014870359,
0.015341602,
0.008011144,
-0.026991796,
0.031075908,
0.00022314537,
-0.0046273516,
-0.0226197,
0.010112106,
-0.010020475,
0.01379697,
0.025394803,
0.01637572,
0.009339789,
0.030421402,
-0.0045488114,
-0.012396329,
-0.014294393,
0.016624432,
-0.00032684352,
-0.0023316748,
0.0044702706,
-0.0014906356,
-0.0044702706,
0.0025149363,
0.004840066,
0.0024871198,
-0.019883867,
-0.019268634,
-0.0041953786,
0.00531131,
-0.0044931783,
0.041024387,
0.019936228,
0.024727207,
0.012422509,
0.0033641567,
0.022004465,
-0.0012083802,
-0.0036128687,
-0.035997786,
0.013168645,
-0.007958784,
0.015263061,
-0.0058578216,
-0.017881082,
-0.0021778662,
-0.012304698,
0.024386864,
0.0009089441,
0.014084952,
0.015852116,
0.0011535655,
-0.00816168,
-0.00810932,
-0.0068788496,
0.0068723047,
0.007160287,
-0.010733886,
-0.012965748,
0.00689194,
-0.005134593,
-0.007998054,
-0.022763692,
0.009634317,
-0.01383624,
0.015446323,
-0.012363603,
-0.004862974,
-0.0018718849,
0.01318828,
-0.017095676,
0.014948899,
-0.018443957,
0.034950577,
0.004614262,
-0.01506671,
-0.016270999,
-0.0008680375,
0.0032741623,
0.014660916,
-0.032306377,
-0.03555272,
-0.0049120616,
0.010301912,
0.006672681,
0.0009023991,
-0.014700187,
-0.015263061,
0.009712857,
-0.0015724488,
-0.0058741844,
-0.01500126,
-0.044794336,
0.009771762,
-0.009241614,
-0.004516086,
-0.015616494,
-0.025748234,
-0.0077362517,
0.016231729,
-0.017763272,
0.019412624,
-0.03385101,
-0.016074648,
0.0051640463,
0.00083940296,
0.009601591,
-0.0009801215,
0.007232283,
-0.0017066223,
-0.043249704,
-0.01134912,
-0.008089684,
-0.008718009,
0.014163493,
0.0064305137,
-0.00021250967,
-0.014857268,
-0.01509289,
-0.008619834,
-0.0054323934,
-0.0015209065,
-0.0010562078,
0.019949319,
0.036704652,
-0.010714251,
0.021952104,
-0.000108402426,
0.015289241,
0.0031596238,
0.022946952,
0.02523772,
-0.028772049,
-0.017357478,
-0.0058807293,
-0.007546445,
-0.012376693,
-0.011859634,
0.014608556,
0.00037818128,
0.039322674,
0.0036848644,
-0.012042896,
-0.038223103,
-0.006898485,
-0.004267374,
-0.0015078164,
-0.008600199,
-0.010753521,
-0.019033011,
0.0025329352,
0.0014530015,
-0.007834427,
0.042176317,
-0.03623341,
-0.02258043,
0.015393962,
-0.015681945,
0.017252758,
-0.00019809009,
-0.012638495,
-0.016729154,
-0.024242872,
-0.027044155,
-0.034400795,
-0.03144243,
0.005586202,
0.013430447,
0.036887914,
0.031782772,
-0.0038059477,
0.001691896,
0.009765218,
0.030814106,
0.010596439,
-0.017292028,
0.021546312,
-0.031049727,
0.038092203,
0.023614548,
0.009038717,
0.030054878,
-0.015145251,
0.01996241,
0.022397168,
-0.013325726,
-0.023012403,
0.008763825,
-0.02269824,
-0.052386597,
0.0324111,
-0.0212976,
-0.005903637,
-0.032070756,
-0.03612869,
0.016532801,
0.009104167,
0.011885814,
-0.022318628,
0.012245793,
-0.017161127,
0.020603824,
-0.008220585,
-0.0025149363,
0.007160287,
-0.027044155,
0.014124222,
-0.0036685017,
-0.0044899057,
-0.015917568,
0.013109739,
-0.020224212,
-0.018457048,
0.0010995688,
-0.004826976,
-0.00089176337,
0.0012059258,
-0.017828722,
-0.016820785,
-0.0012427417,
0.0028012823,
-0.017305117,
-0.029086212,
-0.007232283,
0.007998054,
-0.011159314,
0.010295367,
-0.017881082,
-0.027227417,
0.02125833,
-0.015904477,
0.018234516,
-0.021271419,
0.024779567,
0.023810899,
-0.007827883,
-0.016977865,
0.0116305575,
-0.021742662,
-0.0010962962,
0.027724842,
0.012710491,
0.0062439796,
-0.012520685,
-0.01875812,
0.0046044444,
-0.007912968,
-0.023130214,
0.035840705,
0.002586932,
-0.0022498616,
-0.007251918,
0.0008349032,
-0.009640861,
-0.0062570698,
-0.007696981,
0.025342442,
0.005412758,
-0.0029321834,
-0.015642675,
0.017894173,
-0.015773576,
0.017318208,
-0.0175931,
0.002655655,
-0.024714116,
-0.0047288,
-0.008574018,
0.014909629,
-0.022292448,
0.020904897,
0.0021991376,
0.009824123,
0.0034557874,
-0.012952658,
-0.0147394575,
-0.017357478,
-0.0064108786,
0.032280196,
-0.008233676,
-0.0075922604,
0.028719688,
0.0005051962,
0.006387971,
-0.036809374,
-0.013063924,
-0.016153188,
-0.029138573,
-0.002768557,
0.020590734,
0.009699767,
-0.017724002,
-0.0036488664,
-0.017161127,
0.005884002,
-0.024687937,
-0.019124642,
0.016689884,
-0.027122695,
-0.0011682918,
-0.0048956987,
0.013862421,
0.01882357,
0.01382315,
-0.0047549806,
0.017017135,
0.025342442,
-0.0189152,
0.016860055,
0.008933996,
0.009451055,
-0.0121279815,
-0.006057446,
-0.026075488,
-0.010498264,
0.005789099,
-0.016022287,
-0.02508064,
-0.007775522,
-0.0013973686,
0.0066039576,
0.003832128,
-0.016794603,
0.0050266,
-0.0049546044,
0.01382315,
0.0020616914,
0.0111527685,
0.00627016,
0.012919933,
0.004535721,
0.0055632945,
-0.030421402,
-0.027436858,
-0.013037744,
-0.016270999,
0.0032545272,
-0.0021975012,
0.004591354,
-0.03364157,
0.00947069,
-0.008521657,
0.0011404753,
-0.004198651,
-0.006561415,
-0.018771209,
0.0427261,
0.0046044444,
-0.012978839,
-0.026860895,
0.013901691,
-0.0073435484,
0.010962962,
-0.02769866,
-0.017265847,
-0.00757917,
-0.036809374,
-0.025996948,
-0.0081747705,
-0.02624566,
0.026572911,
0.00082058593,
-0.032254018,
-0.011604377,
-0.00062791596,
-0.043616228,
-0.027881922,
0.006885395,
0.0018407959,
-0.00017252348,
0.032070756,
-0.020263482,
0.01875812,
-0.002663836,
0.006103261,
-0.013404267,
-0.023771629,
0.008286036,
-0.052857842,
0.021637943,
0.014660916,
-0.019622067,
-0.022279358,
0.02014567,
-0.016061557,
-0.01628409,
0.004633897,
-0.014582376,
0.018574858,
-0.004149563,
-0.0026883802,
0.023693088,
0.032987062,
0.005808734,
-0.023719268,
0.0074679046,
0.023090944,
-0.00021394138,
-0.025918406,
-0.015917568,
-0.013286456,
0.0031988942,
0.0013106467,
-0.0022940408,
-0.010445903,
0.008619834,
-0.0050102375,
0.007978419,
0.02504137,
-0.015917568,
0.0149227185,
0.015799755,
-0.012376693,
-0.011028413,
-0.0020666001,
-0.031992216,
0.006227617,
-0.00093757873,
0.0077231615,
-0.014032592,
0.009941934,
0.0067348587,
-0.044323094,
-0.009490325,
0.00057023764,
0.0093332445,
-0.010413178,
0.033013243,
0.026913254,
-0.0044539077,
-0.017972713,
-0.013954051,
-0.038354006,
-0.011938175,
-0.009339789,
-0.029348014,
-0.009215433,
0.0019520618,
-0.010478629,
-0.00085003866,
0.0055829296,
-0.008390757,
0.0050429627,
-0.015249971,
0.028065184,
0.1618984,
0.0024576671,
0.005641835,
0.022357898,
0.020211121,
-0.019124642,
0.02509373,
-0.009699767,
0.013129375,
-0.010131741,
0.01377079,
-0.004921879,
-0.02386326,
0.005694195,
0.03131153,
-0.024111971,
-0.017998893,
-0.0017671641,
-0.014006412,
-0.006247252,
0.008672194,
-0.00066555,
0.014634737,
-0.01123131,
0.033248864,
0.012147617,
-0.025722055,
-0.000016937878,
0.02391562,
-0.021192878,
-0.00814859,
0.019844597,
0.002271133,
0.011250945,
-0.004882609,
0.0095165055,
-0.00048310665,
-0.0149227185,
0.016467351,
-0.01761928,
0.0021975012,
0.017200397,
-0.03154715,
0.010550624,
-0.0006864123,
0.023719268,
-0.025656605,
-0.0024543945,
-0.01381006,
-0.0007101382,
-0.04612953,
-0.003887761,
0.019726787,
0.0041822884,
-0.015996108,
0.0045749913,
0.03146861,
0.017148037,
0.004862974,
0.023352746,
-0.017449109,
-0.0023054946,
-0.026860895,
0.0092219785,
-0.025682785,
0.018011983,
-0.013705339,
-0.019046102,
0.0018391596,
-0.007618441,
0.00345906,
0.0028945494,
-0.004862974,
0.012036351,
-0.010956417,
-0.007814792,
0.010432813,
0.008521657,
0.003334704,
0.007016296,
0.0017131674,
-0.001013665,
-0.028091364,
-0.0073500937,
-0.018273786,
-0.022318628,
0.02000168,
0.017449109,
-0.021192878,
0.0039663017,
0.0041790158,
0.0032496185,
-0.0019569707,
0.0021320507,
0.017475288,
-0.0008074958,
0.004074295,
0.01255341,
-0.004486633,
0.010642255,
-0.031206809,
0.095400676,
0.015393962,
-0.0074809943,
-0.011506202,
0.022946952,
-0.017894173,
0.014058772,
-0.0069312104,
0.012815212,
0.0030532668,
-0.010315002,
0.018928291,
-0.019033011,
-0.028510246,
0.017161127,
0.023666909,
-0.015289241,
0.015498684,
-0.021729574,
-0.029609816,
-0.024478495,
-0.008233676,
0.0053538526,
-0.012108346,
0.0051215035,
-0.017265847,
0.0033936095,
-0.022253178,
-0.02510682,
-0.0055763843,
0.0053211274,
0.0044768155,
0.025787504,
0.023104034,
-0.0034165173,
0.0041462905,
0.013940961,
0.00750063,
0.042254858,
0.0005207407,
-0.004005572,
0.0029518185,
0.027122695,
0.0076118954,
0.0074940845,
0.010930237,
0.0032627084,
-0.013332271,
-0.020957258,
-0.021899745,
-0.026991796,
0.014098043,
-0.009313609,
0.016467351,
-0.020734726,
-0.018928291,
-0.03992482,
0.035448004,
0.0030990823,
-0.026114758,
0.0033936095,
0.027724842,
-0.014176583,
-0.00013938916,
-0.007062111,
-0.16325977,
-0.007782067,
0.0403437,
-0.012167252,
0.0051476834,
0.024373773,
-0.0015339965,
0.015983017,
-0.02506755,
-0.00081976777,
0.03144243,
0.0008124046,
-0.042202495,
-0.021192878,
0.025054459,
0.009267794,
0.014372935,
0.028772049,
-0.0011805638,
0.0013523714,
0.011650193,
-0.01377079,
0.008371121,
-0.025996948,
0.00818786,
0.012926478,
0.010465538,
-0.019556616,
0.007422089,
0.015655765,
-0.02269824,
0.014346754,
0.0048956987,
0.027070336,
-0.000323571,
-0.01509289,
0.0015986289,
0.0023644,
-0.011067683,
0.021192878,
0.024033431,
0.012108346,
0.003346158,
0.010445903,
-0.01015792,
0.008659104,
0.007808247,
0.010269186,
0.04908789,
-0.005275312,
0.03775186,
-0.006041083,
-0.0055502043,
0.01624482,
0.009346334,
0.021729574,
0.010746975,
0.011519291,
0.013652978,
-0.002271133,
-0.006247252,
-0.032044575,
0.012154162,
0.015249971,
0.002470757,
-0.0452394,
0.0021205968,
0.01641499,
-0.015171431,
0.005226224,
-0.029897798,
-0.017161127,
0.031023547,
-0.03018578,
0.026887074,
-0.006178529,
0.0010791154,
0.024674846,
-0.005448756,
0.022148456,
-0.008364577,
0.015524863,
-0.024818838,
0.00050601433,
-0.020263482,
0.016113918,
0.026428921,
0.020616913,
-0.02374545,
0.008056959,
0.025852956,
-0.0004704256,
-0.006083626,
-0.019661337,
0.012978839,
0.018051254,
0.0021598672,
-0.009797943,
0.00037286343,
-0.0079718735,
0.025957678,
-0.015249971,
-0.009562321,
0.0035572357,
0.03131153,
0.019019922,
-0.0060868985,
0.002979635,
0.049663857,
-0.01645426,
-0.019870779,
-0.0011838363,
-0.0051836814,
0.01641499,
-0.011709098,
0.04767416,
-0.0050985957,
0.015197611,
-0.011329485,
-0.02019803,
0.054297753,
-0.008999446,
0.009182708,
0.008652559,
0.0005931453,
-0.032018393,
-0.1398023,
-0.028693508,
0.007638076,
0.021742662,
-0.008168225,
0.018561767,
-0.01644117,
0.015930656,
-0.0051673185,
0.024282143,
0.0034623325,
0.007795157,
0.008128955,
-0.016781515,
0.039244134,
-0.023261115,
-0.0010725704,
-0.0056287446,
-0.03403427,
0.037542418,
-0.009490325,
0.013652978,
0.008790005,
-0.010642255,
0.015852116,
0.017370569,
-0.027515398,
0.006636683,
0.0115389265,
-0.0017867992,
0.007906423,
-0.00096212263,
0.033536848,
-0.0031825316,
-0.020263482,
-0.015799755,
0.014451475,
-0.03555272,
0.041731253,
-0.020184942,
-0.011951265,
0.0035114205,
0.029583635,
0.008384212,
-0.006175257,
-0.01750147,
-0.047255278,
0.0015855388,
0.008842366,
-0.030604664,
-0.044401634,
-0.022043735,
0.007422089,
0.0028405527,
0.011394936,
0.0024478494,
0.0037470423,
0.005573112,
-0.019255543,
0.00015534271,
-0.027724842,
0.015839025,
-0.010190646,
-0.008430027,
0.014621646,
-0.008574018,
-0.019883867,
-0.043825667,
0.005910182,
-0.014281304,
-0.0026965614,
0.017292028,
0.0010562078,
-0.016270999,
-0.030945007,
0.0071079265,
0.01257959,
-0.009542686,
0.014608556,
-0.04251666,
-0.006545052,
-0.016558982,
0.024373773,
-0.011434206,
0.029635996,
-0.00658105,
0.022370989,
-0.0111527685,
0.024792658,
-0.012638495,
-0.017867992,
0.020577643,
0.0056811054,
-0.020368202,
0.004591354,
-0.011754913,
-0.01187927,
0.011682918,
0.03021196,
0.024530856,
-0.0110415025,
-0.022397168,
-0.047333818,
0.018417777,
-0.00050274184,
0.016755333,
0.000727728,
-0.013508988,
0.03159951,
-0.012232702,
0.0045488114,
-0.006139259,
-0.02281605,
0.007847518,
-0.0001215948,
-0.0064305137,
-0.011139679,
0.0010529353,
0.033170324,
0.021768844,
-0.0046862573,
0.015524863,
-0.020407472,
-0.002780011,
-0.008750735,
-0.006191619,
-0.010092471,
0.007998054,
-0.003241437,
0.009928844,
-0.013325726,
-0.0033232502,
0.0052229515,
-0.029086212,
-0.013626798,
-0.019857688,
-0.027148876,
-0.0086329235,
-0.010295367,
0.052281875,
0.020263482,
0.03984628,
-0.021035798,
-0.026991796,
0.026350379,
-0.0108582415,
0.009398695,
-0.004970967,
-0.026887074,
-0.0015871752,
0.0071275616,
0.0005105141,
0.026664542,
-0.0018178882,
-0.006662863,
-0.011034958,
0.0070097507,
-0.008927451,
0.0046273516,
-0.024426134,
-0.018286876,
-0.003308524,
0.014765638,
0.009562321,
0.008999446,
0.0070686564,
0.027515398,
-0.014687097,
-0.018221425,
-0.00814859,
0.0046698945,
-0.0226197,
-0.017056406,
-0.023313476,
0.00008830707,
0.0091303475,
0.009117258,
-0.0010365726,
-0.014961989,
0.010989143,
-0.0036292314,
0.014490745,
0.01886284,
-0.0016706246,
-0.023431286,
0.021716483,
0.018234516,
0.025381712,
-0.0020126035,
0.015878296,
0.008390757,
0.0123308785,
0.007297733,
0.022789871,
0.015537954,
0.021310689,
0.012285063,
0.008089684,
-0.0034426975,
0.008430027,
-0.00011208402,
0.03390337,
-0.0071079265,
0.007919513,
0.0009866667,
-0.022279358,
-0.010072835,
0.018574858,
-0.031023547,
-0.034348432,
-0.019975498,
0.014713277,
0.0019193365,
0.0022547704,
0.014333664,
-0.00750063,
-0.0015667218,
0.028039003,
0.010413178,
-0.004466998,
0.0015659037,
0.028772049,
0.0066039576,
0.004908789,
-0.008652559,
0.008816185,
0.038380187,
-0.009830669,
0.051915355,
-0.0037306796,
0.025813686,
-0.021690303,
0.009235068,
-0.024949739,
-0.035709806,
-0.009077988,
0.0006066445,
-0.024517765,
0.0074679046,
0.021808114,
-0.016192459,
0.074508876,
0.019949319,
-0.030630844,
0.014032592,
-0.01632336,
0.024255963,
-0.0012329242,
0.028274626,
-0.014674007,
-0.015642675,
0.014752547,
-0.0189152,
0.020355113,
-0.020184942,
-0.0071013817,
0.005150956,
-0.006171984,
0.01201017,
-0.0025263901,
-0.005268767,
0.020250391,
-0.021061977,
-0.0022613155,
0.0110611385,
-0.051732093,
0.0076249857,
0.051103767,
0.0043131895,
0.0075988057,
-0.021520132,
-0.0106488,
0.019910049,
-0.027279777,
0.0032430734,
0.0049186065,
-0.027934283,
-0.02759394,
-0.031651873,
0.020957258,
0.03377247,
-0.013116284,
0.0054520285,
-0.024792658,
-0.040448423,
-0.0069508455,
0.006446876,
-0.013626798,
-0.003832128,
-0.007873698
] |
CD25+CD4+ regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family–related gene (GITR, also known as TNFRSF18)—a member of the tumor necrosis factor–nerve growth factor (TNF-NGF) receptor gene superfamily—is predominantly expressed on CD25+CD4+ T cells and on CD25+CD4+CD8− thymocytes in normal naïve mice. We found that stimulation of GITR abrogated CD25+CD4+ T cell | [
-0.04001064,
-0.014457071,
0.004187543,
-0.02530317,
-0.007722738,
-0.0028729641,
-0.03895634,
-0.00009302333,
-0.012816319,
-0.010206929,
0.01792308,
-0.015774945,
0.011900397,
-0.0011992648,
-0.01967585,
0.026252039,
0.039536204,
0.008460747,
-0.012901981,
0.010009249,
-0.023629472,
0.025988465,
-0.010806562,
-0.022298418,
-0.001173731,
0.013356647,
0.008203763,
-0.056088693,
-0.022851925,
-0.023313181,
0.0064806426,
-0.0051100543,
-0.015985806,
0.0051594744,
0.011524803,
-0.03808654,
0.00531103,
-0.02094101,
0.018305263,
0.013784956,
0.014351642,
0.004727871,
0.005946904,
0.015471834,
0.009804978,
0.009066969,
0.019372739,
-0.019939424,
-0.005113349,
0.015419119,
0.014878791,
0.012381421,
-0.017896721,
-0.015801303,
-0.033553056,
0.015326868,
0.005966672,
0.028176134,
-0.006572894,
-0.03674231,
-0.0111162625,
-0.01926731,
-0.0070110867,
0.021151869,
0.014351642,
0.020268893,
-0.010496862,
0.014285748,
-0.011346891,
-0.0137322415,
0.03497636,
0.03479186,
-0.019860353,
-0.012526387,
0.022812389,
-0.00027819484,
-0.006833174,
0.015274153,
-0.00038527205,
-0.011419374,
0.03144446,
-0.026172966,
-0.002255211,
0.017461823,
0.017580431,
0.006500411,
0.007340555,
0.012275991,
0.020545647,
-0.009910408,
0.013073305,
0.020703793,
0.024868272,
0.042909957,
-0.018371155,
0.0087968055,
0.007452574,
0.036610525,
0.00022918642,
-0.03489729,
-0.012137614,
0.018028509,
0.020743327,
-0.015168724,
-0.023906223,
0.005083697,
0.009976302,
-0.0040524607,
-0.0043687504,
-0.021402264,
-0.021375908,
0.03402749,
-0.027227266,
-0.031813465,
0.017725397,
0.014575681,
0.033078622,
-0.0022239115,
-0.0195836,
-0.018634731,
0.018819233,
-0.002752708,
0.015788123,
-0.014760182,
0.015748588,
0.034132924,
0.0071165166,
-0.0027560028,
-0.026278397,
-0.0054197544,
0.021296835,
0.002597858,
-0.0040788185,
0.012717479,
-0.006164353,
-0.003498954,
-0.018898305,
0.0048497743,
-0.006124817,
-0.020585183,
-0.0014043589,
0.038271043,
-0.01155775,
-0.0056009623,
0.018371155,
0.016486596,
0.02592257,
0.013626811,
0.012328706,
0.0070769805,
-0.023089143,
-0.01489197,
-0.0012198566,
-0.00947551,
0.0033869348,
-0.012994233,
-0.009304186,
0.026080715,
-0.020110749,
-0.002945447,
-0.0043786345,
-0.019227773,
0.035529867,
-0.00895495,
0.018081224,
0.027833488,
0.0108131515,
0.03455464,
-0.0013508203,
0.0007421275,
0.02040068,
0.008460747,
-0.015761767,
0.021876698,
-0.010351896,
0.032709617,
-0.025289992,
0.008678197,
-0.006997908,
-0.01218374,
-0.012901981,
0.02978394,
0.022970535,
0.002029525,
-0.009785211,
-0.00020643252,
0.016170308,
-0.00063134375,
-0.0144834295,
-0.007307608,
-0.013073305,
0.015524549,
0.014127604,
-0.02655515,
-0.6334227,
-0.019952605,
0.053505663,
-0.008361907,
0.0132050915,
0.04749616,
0.0048596584,
-0.006355445,
-0.04312082,
0.023589935,
-0.022917818,
0.029652152,
0.017026925,
-0.030232016,
-0.014509787,
-0.033342198,
-0.0264629,
0.003266679,
0.017422287,
0.013811314,
0.00863866,
-0.0015015521,
-0.0021118922,
0.017119177,
0.024947343,
0.02738541,
0.001298929,
-0.03321041,
0.011478677,
0.02051929,
-0.022851925,
0.009804978,
0.012625228,
-0.018344799,
0.04936754,
-0.0044181705,
-0.009837925,
0.031497177,
0.008915414,
0.04594107,
-0.026502434,
0.0023837036,
0.013666348,
-0.0036010891,
-0.036531452,
0.028571496,
-0.0014562502,
0.010951528,
0.012631817,
-0.003040993,
0.000101157086,
0.011650002,
-0.030917311,
-0.00083479047,
0.020163463,
-0.0035088381,
0.021006903,
-0.0028136598,
0.01551137,
-0.010088321,
-0.0027098772,
0.015748588,
-0.0024034716,
0.0041084704,
-0.00505075,
0.0009019196,
0.0034857753,
0.0102925915,
0.027253622,
0.01385085,
0.016262557,
0.03010023,
-0.0031744277,
0.0105166305,
0.0068792994,
0.04301539,
0.00069064804,
-0.0050046244,
0.00557131,
0.010991065,
-0.020690612,
-0.008684786,
-0.0040359874,
0.01686878,
0.009884051,
-0.008289424,
-0.0096204765,
0.01738275,
-0.0078018107,
0.0000024227506,
0.008981308,
0.012157382,
-0.034686428,
-0.026950512,
-0.01271089,
0.021217762,
0.00426991,
0.015564085,
0.005913957,
-0.016091235,
-0.006101754,
-0.016302094,
0.016420703,
-0.0059831454,
0.016328452,
0.020150285,
-0.055350684,
0.007538236,
0.04749616,
-0.022522457,
-0.004823417,
0.017224606,
0.0013796488,
-0.011630233,
-0.007406449,
-0.011814736,
0.014826076,
0.011393016,
-0.01800215,
-0.021085976,
0.027965274,
0.0031299493,
0.021942593,
0.008085154,
0.009798389,
-0.006645377,
-0.015656337,
-0.022153452,
0.021718554,
0.00060416263,
0.005007919,
0.0023738195,
0.018713802,
-0.024723306,
0.042804528,
-0.0020509406,
0.028466066,
0.01884559,
0.00006676882,
-0.030390162,
-0.03842919,
-0.017198248,
0.017040104,
-0.0070044976,
-0.005185832,
0.018871948,
0.01187404,
0.014839255,
0.010661596,
-0.007755685,
0.011399605,
0.0035780263,
0.0015970978,
0.0050375713,
0.026067536,
-0.011300765,
-0.019188236,
-0.03402749,
0.014114425,
-0.0032403213,
-0.0019142112,
0.021903057,
-0.01510283,
0.010589113,
-0.025751246,
0.0046487986,
0.0037987703,
0.016275737,
0.012124436,
-0.035371725,
-0.013758599,
-0.014667931,
-0.006101754,
0.014008995,
0.015326868,
-0.009099917,
-0.012361653,
-0.022469742,
0.0018763223,
-0.0005287967,
-0.0066058408,
-0.004833301,
0.004925552,
-0.011946523,
0.027438125,
0.003133244,
0.0041084704,
0.022535635,
0.005281378,
0.023062786,
-0.03010023,
0.0009991128,
-0.041829303,
0.038560975,
0.0035648476,
-0.037322175,
0.010997654,
0.022654245,
-0.004935436,
0.02988937,
-0.018252548,
-0.029230433,
0.027886203,
-0.027543554,
0.01727732,
-0.009534814,
-0.005890894,
-0.024103906,
0.01311943,
-0.007986313,
0.0038910212,
0.014575681,
0.007413038,
-0.0057426337,
0.008684786,
-0.0075645936,
-0.009416206,
-0.013172145,
0.00075818907,
-0.03342127,
0.0015188492,
0.017026925,
0.012664764,
-0.0074591637,
-0.0067343335,
0.022733318,
0.0017132355,
-0.0026686937,
0.008296013,
-0.018410692,
-0.015445476,
-0.017738577,
0.00018862063,
0.004381929,
0.010885634,
-0.0057525174,
-0.0032073746,
-0.017778113,
0.030864596,
-0.002900969,
0.014536144,
0.00577558,
0.005505416,
-0.008816574,
-0.0061050486,
-0.0094821,
0.00039103776,
0.0052023055,
-0.008282835,
0.015893554,
-0.017949436,
0.009804978,
-0.004602673,
0.008882467,
0.015577264,
0.010154215,
0.0069517824,
-0.0109647075,
0.0372431,
0.026067536,
0.025738068,
0.0053143245,
0.002439713,
-0.021534052,
0.0037987703,
0.020347966,
0.0026390415,
-0.007749096,
0.000009871181,
0.006477348,
-0.034080207,
0.022430206,
0.019254131,
-0.011926754,
0.009251472,
0.031497177,
0.0079731345,
0.013837671,
0.016117591,
-0.00028293097,
0.013389594,
-0.037453964,
0.032419685,
0.015050115,
-0.0072285356,
-0.00075654173,
-0.026423363,
-0.022614708,
-0.004437939,
0.0052912617,
0.007854526,
0.00791383,
0.017316857,
0.0055844886,
0.0036010891,
-0.026924154,
0.031075455,
-0.0289405,
0.003518722,
-0.0042106058,
0.02322093,
-0.0014628395,
0.0006955901,
0.0029948675,
0.0029619206,
-0.00007536589,
-0.005199011,
-0.01688196,
-0.010589113,
-0.014325284,
0.0052583152,
0.0018104287,
0.0065959566,
-0.042251024,
0.004853069,
-0.003759234,
0.009455742,
0.007123106,
0.012664764,
-0.003518722,
-0.000031968728,
-0.022667423,
-0.0051100543,
-0.020545647,
0.014799719,
0.02957308,
-0.010332128,
0.013574096,
-0.008889057,
0.0037526446,
-0.006124817,
-0.027675342,
0.011617054,
-0.014233033,
-0.010562756,
0.0003496483,
0.013112841,
-0.0112612285,
0.02040068,
0.01114262,
0.0027543555,
-0.014246212,
-0.015405941,
0.0029306212,
0.025566746,
-0.0017988973,
0.00844098,
0.02071697,
0.008994486,
-0.024696948,
-0.0021036554,
0.02904593,
-0.008618892,
-0.012262813,
0.007643666,
0.015880374,
0.003551669,
0.0052649044,
0.00017482415,
-0.033658486,
0.010483683,
0.009864283,
0.0006939427,
-0.021165047,
0.01051004,
0.012612049,
0.014101245,
-0.013521382,
0.002415003,
-0.014694289,
0.0030640557,
0.00635215,
-0.00007140197,
-0.01124805,
0.016895138,
-0.019399097,
-0.018331619,
-0.008579356,
0.0032897417,
-0.0017362982,
-0.0037328766,
0.0007911359,
0.003686751,
-0.020585183,
-0.00296851,
-0.02685826,
-0.012816319,
-0.012025595,
-0.016104413,
-0.0014307164,
0.004204016,
-0.01646024,
-0.017685862,
-0.026199324,
0.006780459,
-0.028360637,
-0.016407525,
0.019438634,
-0.0053143245,
-0.009403027,
0.010971297,
0.0004369574,
0.004279794,
0.020176642,
-0.014391178,
-0.006250015,
-0.009343723,
-0.01895102,
0.005884305,
-0.023721723,
0.0001736916,
0.00013281693,
-0.027042763,
0.009001075,
-0.0026785778,
-0.017422287,
0.009396438,
0.008889057,
-0.0048464797,
0.0051199384,
0.032604188,
0.014997399,
-0.0014562502,
0.0006609959,
-0.014048531,
-0.00635215,
-0.01228917,
-0.02364265,
-0.011399605,
-0.014298927,
0.019504527,
0.009884051,
-0.0019504527,
-0.013462077,
0.014984221,
-0.0077425065,
-0.012532976,
-0.01591991,
0.011992648,
0.019412275,
0.0030673505,
0.017844006,
0.009943355,
-0.027200907,
-0.008875878,
-0.017119177,
0.034185637,
0.013666348,
-0.0037526446,
-0.0011646707,
-0.01696103,
-0.0067310384,
-0.028334279,
-0.01155116,
-0.01739593,
0.009403027,
0.01062206,
-0.012361653,
-0.021494515,
0.01197947,
-0.016486596,
0.025474494,
-0.0034034082,
-0.022008486,
-0.039588917,
0.00915922,
0.00063752127,
-0.01748818,
0.0001161376,
-0.03521358,
-0.011880629,
0.00958094,
0.01926731,
0.015353225,
-0.008612303,
0.006826584,
-0.027411768,
0.0049420255,
-0.008487105,
-0.03289412,
0.0047015133,
0.0027938916,
0.042857245,
0.023655828,
0.03133903,
0.003166191,
0.029230433,
0.01947817,
0.009218525,
0.017211428,
-0.0033556353,
0.03394842,
-0.012374831,
0.002232148,
0.007696381,
-0.012170562,
0.013547739,
-0.014351642,
-0.0037559394,
0.00676728,
-0.023207752,
-0.007136285,
0.014602038,
-0.02780713,
-0.045440275,
0.027517198,
-0.015972625,
0.005343977,
-0.030047515,
-0.002910853,
0.04905125,
0.016302094,
0.013007411,
0.0049947402,
0.040326927,
-0.033500344,
0.006019387,
-0.005195716,
0.014562502,
-0.019965783,
-0.013719062,
0.016275737,
-0.005060634,
0.016934674,
-0.0029520364,
0.005060634,
0.014878791,
0.00411506,
0.011412784,
0.001419185,
-0.028492425,
-0.023774438,
-0.013771777,
-0.02862421,
-0.025896214,
-0.009053791,
-0.019227773,
-0.012275991,
-0.001739593,
0.008625481,
-0.027754415,
0.0071889996,
-0.011617054,
-0.024644233,
0.020242536,
-0.002973452,
0.037005886,
-0.008032438,
0.011103083,
0.020334788,
0.009396438,
-0.029098645,
-0.006164353,
0.008480515,
-0.017198248,
0.03239333,
0.02290464,
0.0019191531,
-0.026001643,
0.013890386,
0.01124805,
-0.009574351,
-0.022548815,
0.007841347,
0.00288779,
-0.0064411066,
-0.023207752,
-0.01124805,
-0.029942084,
0.011584108,
-0.0013294049,
0.002760945,
-0.0029388578,
-0.007175821,
-0.025487673,
0.020203,
-0.022957355,
0.014285748,
-0.0043061515,
-0.008902235,
-0.01530051,
-0.028439708,
0.0041809534,
-0.00335893,
-0.0036702775,
0.0372431,
0.006507,
0.0030722925,
0.030179301,
-0.01968903,
0.008856109,
-0.00437534,
0.001116074,
0.040353283,
-0.0013203445,
-0.010332128,
0.013369826,
-0.005442817,
0.0025171384,
-0.016855601,
-0.0031513649,
0.0068068164,
-0.02854514,
-0.019412275,
0.019082807,
0.009066969,
-0.022996891,
0.027728057,
-0.020914651,
-0.016064877,
-0.04188202,
-0.015788123,
0.034132924,
-0.029441293,
0.0035977946,
0.009758852,
0.011689537,
0.008091743,
0.012374831,
0.0035351955,
-0.0071560526,
0.037111316,
-0.041328512,
0.018252548,
0.00967978,
0.010088321,
-0.017409109,
0.00042830888,
-0.010325538,
-0.032841407,
0.00047484628,
-0.015669515,
-0.034686428,
-0.029309506,
-0.0033243357,
0.013916744,
0.011946523,
-0.005821706,
0.02696369,
0.01842387,
0.020598361,
0.010108089,
-0.004138123,
0.021626303,
-0.0038976108,
-0.023194572,
0.019240953,
-0.013053536,
-0.019794459,
0.00598644,
0.0050968756,
0.017066462,
-0.00687271,
-0.015537728,
-0.012315528,
0.003518722,
-0.024222514,
-0.0007804282,
-0.0015344989,
0.008875878,
-0.031602606,
0.020387502,
0.01718507,
-0.024169799,
-0.016552491,
0.019280488,
-0.0028729641,
0.01686878,
-0.009758852,
0.0022057907,
-0.010424379,
-0.017211428,
-0.047127154,
-0.004082113,
-0.018068045,
0.027675342,
-0.005624025,
-0.008276246,
-0.017448645,
0.017580431,
-0.014799719,
-0.0064806426,
-0.00085002836,
0.00479047,
-0.0033243357,
0.0062763724,
-0.03165532,
0.0026489256,
-0.021692198,
0.025711711,
0.00085579406,
-0.016710635,
0.006684913,
0.008559588,
0.022891462,
0.009034023,
-0.027200907,
-0.03257783,
0.030996384,
-0.0042139003,
-0.0005312677,
0.019346382,
-0.01780447,
0.023273645,
-0.027569912,
0.0033473985,
-0.016183486,
0.02248292,
0.036188804,
-0.00801267,
0.008243298,
0.012875623,
-0.0077754534,
-0.0011778494,
-0.0046553877,
0.0075316466,
-0.006572894,
0.01103719,
-0.0075250575,
-0.01738275,
0.0012042068,
-0.013626811,
0.01812076,
0.018779697,
-0.010529809,
-0.0011506682,
-0.0019273899,
-0.020677434,
-0.017646326,
-0.014298927,
-0.0014035353,
0.001999873,
-0.008368497,
-0.004006335,
-0.0070572123,
0.009495278,
0.013462077,
-0.017330036,
0.003078882,
-0.007814989,
0.011485267,
-0.039325345,
0.004372045,
0.011267818,
-0.0029635679,
-0.0035747318,
-0.0061215223,
-0.015195081,
-0.017725397,
0.0018433755,
-0.016908316,
-0.0078940615,
-0.029125003,
-0.0007977253,
-0.011808146,
-0.006714565,
-0.0151555445,
-0.018806053,
-0.019016914,
0.025883034,
0.19641586,
-0.035266295,
0.002505607,
-0.006892478,
0.011412784,
-0.0008978013,
0.0045334846,
-0.010839509,
-0.019544063,
0.007623898,
0.011867451,
0.02518456,
-0.009778621,
-0.001231388,
0.004431349,
-0.022667423,
-0.03634695,
-0.007927009,
-0.021534052,
-0.014338463,
0.024644233,
-0.0062203626,
0.019702207,
0.0040030405,
0.036795028,
0.009515046,
-0.024710126,
0.002227206,
0.0162362,
-0.00012241809,
-0.035688013,
0.008098332,
-0.0088692885,
-0.009561172,
0.006852942,
0.011827914,
-0.028808713,
-0.003498954,
0.012664764,
-0.009870872,
0.0019932836,
-0.020782864,
-0.006599251,
0.004602673,
-0.0012659822,
0.024947343,
0.007788632,
-0.007413038,
-0.009291008,
-0.0062434254,
-0.04509763,
-0.008104921,
0.014773361,
0.017778113,
0.019003736,
-0.0023524042,
0.013172145,
0.005334093,
0.009765442,
0.02228524,
-0.01760679,
0.008183994,
-0.04372704,
0.044517767,
-0.013719062,
0.024301587,
-0.021033261,
0.0035121327,
0.009495278,
-0.027148193,
0.0063093193,
0.005442817,
-0.013890386,
-0.013112841,
-0.0048431847,
0.0054065757,
0.007518468,
0.0060424497,
0.0034231762,
0.013903565,
-0.0017560663,
0.003266679,
-0.019201417,
0.003581321,
-0.015063293,
-0.034001134,
0.012532976,
0.017659504,
-0.025777604,
0.0018005446,
0.008183994,
-0.0024265344,
-0.010424379,
-0.011307354,
0.002052588,
0.0151555445,
0.00011109261,
0.0022980417,
0.0044280547,
-0.0070506227,
-0.03748032,
0.066473536,
0.017330036,
0.024525626,
-0.013040357,
0.021534052,
0.003989862,
-0.0024891335,
-0.015669515,
-0.008889057,
0.01187404,
-0.010806562,
0.007445985,
0.00614129,
0.0034396497,
0.020848759,
-0.0024117085,
-0.004464296,
0.011946523,
-0.01468111,
-0.005913957,
-0.026726473,
0.0035582583,
0.01322486,
-0.0019488054,
0.018147117,
-0.011300765,
-0.011228282,
-0.0050474554,
-0.049077608,
-0.0024248871,
-0.023695365,
0.009264651,
0.015814481,
0.023510862,
-0.007406449,
0.014351642,
-0.039509844,
-0.023932582,
0.034844574,
-0.0073273764,
0.0001464075,
0.009673191,
-0.0162362,
0.004879426,
0.003055819,
0.013679527,
0.0162362,
-0.013495024,
-0.0031777225,
-0.00056998024,
-0.02925679,
-0.010938349,
-0.009251472,
0.030495591,
-0.031576246,
-0.013798135,
-0.036267877,
0.0020064623,
0.018344799,
-0.021151869,
0.015537728,
0.027332695,
-0.004984856,
0.0024973701,
0.0015279095,
-0.16520861,
0.016078057,
0.0051462958,
-0.012223276,
0.029599437,
0.0012552744,
-0.011070137,
0.014549322,
-0.0037757074,
0.020677434,
0.05988417,
0.007538236,
-0.038850907,
-0.0024907808,
-0.0074723423,
-0.006684913,
-0.0007095925,
0.037401248,
0.015274153,
0.030126587,
0.033553056,
-0.029019574,
0.011992648,
-0.032630548,
-0.003446239,
0.02395894,
0.014826076,
-0.02009757,
-0.00314807,
-0.008460747,
-0.013890386,
0.012638406,
0.02344497,
-0.003831717,
0.020585183,
0.005703097,
-0.0104112,
-0.02925679,
-0.003864664,
0.036215164,
0.024341123,
-0.0029503892,
0.003363872,
0.01572223,
-0.026410183,
0.021217762,
-0.00283837,
0.007538236,
0.021995308,
-0.009864283,
0.01874016,
-0.006714565,
-0.0034297656,
0.020703793,
0.0224961,
0.006207184,
0.016051698,
0.014088067,
-0.0049222573,
-0.013389594,
0.0045334846,
-0.029230433,
0.036373306,
-0.0023458148,
0.012025595,
-0.026818724,
0.0006515237,
-0.004823417,
-0.012849266,
-0.00629614,
-0.04074865,
0.00025019003,
0.00546588,
-0.019425454,
0.013290754,
0.015998984,
-0.017988972,
0.028861428,
0.0070044976,
0.015906733,
0.0072285356,
-0.012341885,
-0.034291066,
-0.01591991,
-0.012532976,
-0.00822353,
0.015260975,
0.016592026,
-0.00092086405,
0.0096138865,
0.021613125,
-0.011195335,
-0.008987897,
-0.0040524607,
0.013488434,
0.008803395,
0.00016524897,
0.0023145152,
-0.014008995,
0.007735917,
0.032946836,
-0.028255207,
-0.012117846,
-0.0047344603,
0.016328452,
0.009930177,
-0.020677434,
-0.0003531489,
0.028993215,
-0.002270037,
-0.0021333077,
0.031259958,
-0.009660012,
0.023576755,
-0.0007610719,
0.0071165166,
0.01634163,
-0.015788123,
0.016499776,
-0.025514029,
0.067633264,
0.018700624,
-0.013455488,
0.023510862,
-0.0020114044,
-0.022417028,
-0.13442309,
-0.034923647,
0.020558827,
-0.0046553877,
-0.035477154,
0.009567761,
-0.019833995,
0.03239333,
-0.01730368,
0.014417536,
-0.012888802,
-0.003726287,
0.009007665,
-0.009732495,
0.0060655125,
0.012677942,
0.015326868,
-0.015326868,
-0.01935956,
0.031602606,
0.009508457,
-0.01748818,
0.0035681424,
0.0064312224,
-0.010154215,
0.004497243,
-0.025764426,
0.02154723,
-0.0037164032,
0.01730368,
-0.0004066875,
-0.001356586,
0.039193556,
-0.0090933265,
-0.039404415,
-0.00156168,
-0.0068858885,
-0.018700624,
0.035529867,
0.001549325,
-0.009818157,
0.007623898,
-0.006675029,
0.01363999,
-0.0095414035,
-0.0133237,
-0.03257783,
0.0013598807,
0.01967585,
-0.017224606,
-0.028993215,
-0.03808654,
-0.003368814,
-0.007274661,
0.010496862,
0.008131279,
0.025461314,
0.02759627,
0.002718114,
0.00169182,
0.040432356,
-0.009152631,
0.013185324,
0.021784447,
0.02341861,
0.011465499,
-0.014905148,
-0.026700117,
0.019425454,
-0.025579924,
-0.0013129314,
-0.018806053,
-0.015643157,
-0.020137107,
-0.007986313,
0.017013745,
-0.007735917,
-0.013422541,
0.01374542,
-0.041460298,
-0.01676335,
-0.018094402,
0.012407779,
-0.006345561,
0.047654305,
-0.00050120376,
0.0054724696,
-0.006780459,
0.010173983,
-0.017962616,
-0.0060062082,
0.025738068,
0.0023968823,
-0.0111162625,
-0.02801799,
0.0037328766,
-0.00040030407,
0.014944685,
0.0060556284,
0.014984221,
-0.003363872,
-0.020558827,
-0.056879416,
0.01000266,
-0.008994486,
0.022851925,
0.011393016,
-0.022272062,
0.006800227,
-0.019188236,
0.011373248,
0.0058447686,
-0.019240953,
0.015366404,
-0.0073866807,
0.011906986,
-0.037638467,
-0.012098079,
0.01707964,
0.003373756,
0.019873532,
0.02801799,
-0.009310775,
-0.00853982,
-0.002795539,
0.008309192,
-0.007623898,
0.0127043,
-0.004862953,
0.034686428,
-0.0061973,
-0.010826331,
-0.0039799777,
-0.03906177,
-0.01530051,
0.010911992,
-0.018937841,
-0.017316857,
0.010094911,
0.027622627,
0.019939424,
0.01874016,
-0.028255207,
-0.048787676,
0.025975285,
0.00676728,
0.0074986997,
-0.015774945,
-0.03426471,
0.007768864,
0.010239877,
-0.01176202,
0.02332636,
0.0061775316,
0.0033473985,
-0.023458147,
-0.018476585,
-0.0071296953,
-0.015221438,
-0.015550907,
-0.03895634,
-0.011880629,
0.013270985,
0.011986059,
0.0111162625,
0.008632071,
0.013995816,
-0.012921749,
-0.044333264,
0.003518722,
0.034343783,
-0.014101245,
-0.03197161,
0.010694543,
0.013363237,
-0.0021135395,
0.0132050915,
-0.006404865,
-0.030653736,
0.0019652788,
-0.02198213,
0.026845083,
0.019662673,
-0.014127604,
-0.012163972,
0.005432933,
0.01968903,
0.0042073107,
-0.00927124,
-0.0013302285,
0.012480262,
0.0042633205,
-0.023893045,
0.009930177,
0.006800227,
0.011775199,
0.013086483,
0.031418104,
-0.0002049911,
0.015748588,
0.0056998027,
0.05166064,
0.007999492,
0.00005155665,
0.0063027297,
-0.0008199644,
0.016381167,
0.019530885,
-0.04322625,
-0.042857245,
-0.028571496,
-0.0053406823,
0.004477475,
0.0032765628,
0.002810365,
-0.0015369699,
-0.022535635,
0.0092448825,
-0.014509787,
0.0054724696,
-0.010753848,
0.0047937646,
0.02208756,
0.006299435,
-0.004569726,
-0.013758599,
-0.00056050805,
0.00572616,
0.025764426,
-0.014457071,
0.015076472,
-0.028439708,
0.025566746,
0.006964961,
-0.025975285,
-0.01207172,
-0.0115643395,
-0.010971297,
-0.0014200086,
0.02260153,
-0.013929922,
0.08766494,
0.009930177,
-0.007940187,
-0.00006821025,
-0.008552998,
0.013903565,
-0.0024067664,
0.03197161,
-0.0220612,
-0.030996384,
0.03977342,
-0.014509787,
0.027938917,
-0.035925232,
-0.027543554,
0.016605206,
-0.017158711,
-0.010114679,
0.02175809,
0.0033473985,
-0.007927009,
-0.022324776,
-0.00023783497,
-0.00014712822,
-0.03376392,
-0.015682694,
0.038481906,
0.004559842,
-0.0037822968,
-0.01591991,
0.003571437,
-0.0019965782,
-0.05094899,
-0.007301019,
-0.0015625037,
-0.044306904,
-0.04198745,
-0.017738577,
-0.0006539947,
0.014984221,
0.0017082935,
0.021230942,
-0.014496608,
-0.012216687,
0.026014822,
0.0018730276,
-0.036795028,
0.0025187857,
-0.012901981
] |
Low case detection rates of new smear-positive pulmonary tuberculosis (PTB) patients globally are a cause for concern. The aim of this study was to determine for patients registered for TB in Malawi the number and percentage who lived in a neighbouring country and the registration, recording and reporting practices for these 'foreign' patients. All 44 non-private hospitals, which register and treat all TB patients in the public health sector in Malawi, were visited. Ten (23%) hospitals in 2001 and 14 (32%) in 2002 maintained a separate register for cross-border TB cases. Patients recorded in these registers were not formally reported to | [
-0.002813604,
-0.011845008,
0.02411471,
-0.04398247,
0.0030309283,
0.012906744,
-0.0064002853,
-0.0015021925,
-0.021964692,
0.0015013629,
-0.0204119,
0.019429794,
0.02249556,
0.014001661,
0.0010982346,
0.018514045,
0.031055817,
-0.018766208,
0.0022313073,
-0.026264727,
-0.02319896,
0.014134378,
-0.016669275,
0.020491531,
-0.0059390934,
0.0023690015,
0.02605238,
-0.032436077,
-0.0087460615,
-0.009694989,
-0.0011587867,
-0.020146465,
-0.021778887,
0.0033444725,
-0.027578628,
-0.0096419025,
0.024141252,
-0.016748907,
0.03317929,
-0.0026958175,
0.010464748,
0.013829129,
0.008885414,
0.017930089,
0.012050719,
0.00019275094,
0.025083544,
0.0051693334,
-0.051626977,
0.002956275,
-0.0021317694,
0.012409055,
-0.028428016,
0.0039417,
-0.004681598,
-0.017969904,
-0.016178222,
0.019814674,
-0.0061182613,
-0.02991445,
-0.011048704,
0.016722362,
-0.03774476,
0.010736818,
-0.020956041,
-0.015899517,
-0.009210572,
0.0038222545,
0.012223251,
0.018062806,
0.0164702,
0.007976302,
0.010929259,
-0.009177392,
0.024021806,
-0.01310582,
0.007425525,
-0.0038089827,
-0.03023297,
0.0217258,
0.010152863,
-0.018766208,
-0.009203935,
0.019960662,
0.019960662,
-0.0064002853,
0.0044659325,
0.009734804,
-0.0025465107,
-0.0042038164,
-0.0064401003,
0.01956251,
0.00077473646,
0.00009964156,
0.0055940286,
0.009542365,
-0.013145635,
0.03225027,
0.011805192,
-0.05032635,
-0.014014932,
0.007637873,
-0.0440621,
-0.02063752,
0.0012873565,
0.029357037,
-0.015289018,
-0.0153951915,
0.013258445,
-0.011652567,
-0.020969313,
0.035223138,
0.020000476,
-0.023398036,
0.027007943,
0.0016672594,
-0.012249795,
-0.005086385,
0.0053485017,
0.0006855671,
0.023544025,
0.004827587,
0.002382273,
-0.018660033,
0.014426356,
-0.012409055,
-0.0034871434,
-0.022362843,
-0.01954924,
-0.0054978086,
-0.018022992,
-0.013709683,
0.009130941,
0.0022080818,
0.0074653407,
0.00086432055,
-0.019681957,
-0.020385357,
-0.040478736,
-0.040000953,
0.016337482,
0.03447992,
0.004077735,
-0.028507648,
-0.0017634793,
0.051600434,
0.023836004,
0.0052788253,
-0.014014932,
0.0046484186,
-0.008593436,
-0.014373269,
-0.014214008,
-0.0048474944,
-0.008294823,
-0.009383104,
0.024871197,
0.020053564,
-0.018102622,
-0.013789314,
-0.0408238,
0.014160922,
0.008128926,
-0.0073326235,
0.00069261773,
0.030100252,
-0.011858279,
0.010458113,
0.00058727345,
-0.0049337605,
0.004787772,
0.026715966,
-0.01879275,
0.017837187,
0.01879275,
-0.010385118,
-0.038302176,
-0.00083902135,
-0.032728054,
-0.018155709,
-0.028242214,
0.020650791,
0.021208202,
0.019310348,
-0.025388794,
-0.014784692,
0.0018049534,
-0.013411069,
0.010332031,
-0.007080461,
0.015899517,
0.011699018,
-0.003951654,
0.013696412,
-0.6455363,
-0.0063107014,
0.019270532,
-0.015488094,
0.0030724024,
0.013245173,
0.0045157014,
-0.01275412,
-0.039310824,
0.025441881,
-0.0027787657,
0.025468424,
0.01233606,
-0.013019554,
-0.00974144,
-0.017226689,
-0.0033063164,
0.008659795,
0.016191494,
-0.014426356,
-0.009602087,
0.032223728,
0.0042668567,
0.03779785,
-0.010809814,
0.002677569,
0.01140704,
-0.009608723,
0.004714777,
0.022827353,
-0.022004506,
0.0003241202,
0.00711364,
0.014346725,
0.033736702,
-0.017731013,
-0.016085321,
0.023703286,
0.017332861,
0.0066192686,
0.000018080122,
-0.00034216145,
0.025614413,
-0.003553502,
-0.00093233807,
0.025455153,
0.0039981045,
0.001052613,
0.012939923,
-0.013656597,
0.006708853,
0.013696412,
-0.021301106,
0.002058775,
0.033258922,
0.0038487979,
0.0069477437,
-0.011154878,
0.008354546,
-0.010624009,
-0.015235931,
-0.009263658,
0.011652567,
-0.0070605534,
-0.025229534,
-0.0134840645,
-0.005590711,
0.012249795,
-0.0054978086,
-0.0033560854,
0.012010903,
0.034771897,
-0.003560138,
0.014174193,
0.020597704,
0.023676742,
0.0109491665,
-0.01453253,
-0.02760517,
-0.0054015885,
-0.008898686,
0.013935302,
-0.018487502,
-0.015182843,
0.016841808,
0.0067553036,
-0.01800972,
0.001683849,
0.014373269,
0.01916436,
0.0034274207,
0.007757318,
0.0025962796,
-0.015726984,
-0.0078037693,
0.017810645,
-0.008361181,
-0.030047167,
0.015992418,
-0.016430385,
-0.029463211,
-0.032117553,
0.02372983,
0.0028600548,
0.0075516067,
-0.008308095,
-0.038408346,
-0.010166135,
0.031745948,
-0.038939215,
0.0037625316,
-0.019230718,
0.016456928,
-0.01398839,
0.036895372,
-0.02797678,
0.014293639,
0.002481811,
-0.012044082,
-0.010278945,
0.015554452,
0.018527316,
0.024380144,
-0.016894896,
0.012893473,
0.017996447,
0.027114118,
-0.028560733,
0.011188057,
-0.01357033,
-0.015580995,
0.0011206305,
0.039841693,
-0.004505748,
0.04106269,
-0.005570803,
0.0012093852,
0.0019990522,
-0.019814674,
-0.0321441,
-0.040054042,
-0.02063752,
0.024791567,
0.018381327,
0.0099936025,
-0.028268756,
-0.0055475775,
0.0032980216,
-0.019695228,
0.008613344,
0.00022333811,
-0.005524352,
0.009104397,
-0.0138424,
-0.0010791564,
-0.0049437145,
-0.0071866345,
-0.014174193,
-0.0070870966,
-0.01623131,
0.013935302,
0.008062568,
0.009655174,
-0.011294231,
0.025893118,
-0.013935302,
-0.0059158676,
0.009728168,
0.027950235,
-0.028109496,
0.014041476,
-0.018540587,
-0.00090164726,
0.012866929,
0.010730183,
0.00005687138,
0.0027754477,
0.005663705,
0.002249556,
-0.025335707,
-0.011586209,
0.005567485,
0.011141606,
0.010570922,
0.017226689,
0.011891458,
0.0040180124,
-0.019137815,
0.01376277,
0.024220882,
-0.00025174787,
-0.009257022,
-0.01009314,
0.013643324,
-0.00021856859,
0.01012632,
0.030498404,
0.0217258,
-0.00495035,
0.030020623,
0.005381681,
0.016815266,
0.043557774,
-0.009071218,
0.00020591897,
-0.01978813,
-0.0010210926,
-0.03811637,
0.030631121,
0.0080824755,
0.003274796,
-0.03317929,
0.008341274,
0.0039616073,
-0.009960423,
0.026357628,
0.007438797,
-0.0004757081,
-0.017412493,
0.007856856,
-0.026490346,
0.0025863259,
0.021128573,
0.02017301,
-0.00038342818,
-0.0073326235,
0.014625432,
0.0043863025,
0.01059083,
-0.0018115893,
-0.03246262,
0.0025348978,
0.033816334,
0.014651976,
0.018567132,
-0.010776634,
-0.004137458,
-0.009568907,
0.011227872,
-0.008838964,
0.005540942,
0.013590238,
0.008832327,
0.0027489043,
0.0030392231,
0.0103652105,
0.011048704,
0.011586209,
-0.010385118,
0.023836004,
0.007365803,
-0.0005101316,
-0.016005691,
0.0063007474,
-0.0073193517,
-0.006489869,
-0.000938974,
0.016337482,
0.027167205,
0.022256669,
0.019655412,
-0.005000119,
0.002100249,
-0.027087573,
0.026928313,
-0.011732197,
-0.015262474,
-0.022004506,
0.019668683,
0.00037388914,
-0.015315561,
-0.017133785,
0.027870605,
-0.02845456,
0.0034274207,
0.010756726,
-0.01113497,
0.00087593327,
0.020080106,
0.0019725088,
-0.046530638,
-0.024526132,
0.01716033,
0.017890275,
-0.01275412,
-0.033683617,
0.0024021808,
0.017664654,
-0.02797678,
0.028746538,
0.008898686,
-0.008692974,
-0.008062568,
-0.006314019,
-0.0072330856,
-0.0056437976,
0.0289058,
0.004714777,
0.021951418,
-0.004034602,
-0.014320183,
0.00834791,
-0.015156301,
-0.022469016,
0.0033394957,
-0.015607539,
-0.008460719,
-0.0034805078,
-0.026171826,
0.01020595,
-0.000315618,
0.008580165,
-0.003190189,
0.017173601,
-0.0047479565,
0.011446856,
-0.0122166155,
0.035754006,
0.02017301,
-0.02357057,
-0.033285465,
-0.018421143,
-0.013855672,
-0.0058329194,
0.0796303,
-0.0026377537,
0.0003037979,
0.007027374,
0.0011762059,
0.003042541,
0.0033477906,
-0.04159356,
0.018129164,
0.0052721896,
-0.00943619,
0.006788483,
0.017332861,
0.02281408,
0.02457922,
0.019058185,
0.013251809,
-0.015050126,
0.0035402304,
0.019111272,
0.005102975,
-0.01786373,
0.019443065,
0.045787424,
0.015448278,
0.007153455,
0.012714305,
-0.01615168,
0.018421143,
-0.017903546,
-0.021513453,
0.028826168,
-0.01546155,
0.014691791,
-0.0034506463,
0.013039461,
0.028268756,
0.00908449,
-0.0131721785,
0.005282143,
0.03562129,
0.0119047295,
0.0059191855,
0.0056371614,
0.017585024,
0.005603982,
0.0048010433,
0.023079515,
0.01824861,
-0.011838371,
0.05813012,
-0.0217258,
0.008367817,
-0.025070272,
0.003186871,
-0.006980923,
0.0024635624,
0.0045721065,
-0.005617254,
-0.0027472454,
-0.038381804,
-0.029649016,
0.004628511,
0.0050432524,
-0.022482287,
0.0036895373,
-0.024711937,
-0.000679346,
-0.004714777,
-0.010736818,
-0.0035302767,
-0.04069108,
-0.023092788,
0.0020272548,
0.021539995,
0.012024175,
0.010358575,
-0.0067420322,
-0.00562389,
0.016788721,
-0.020385357,
0.015302289,
-0.00019658731,
-0.023384765,
0.006045267,
0.016602917,
0.0106173735,
-0.00374926,
-0.034771897,
0.025720587,
-0.014081291,
-0.0023043018,
-0.010889444,
0.018129164,
0.016005691,
-0.00052298856,
-0.0038620695,
0.02087641,
-0.025840033,
-0.017996447,
0.0037691675,
-0.02906506,
-0.0069012926,
-0.00570352,
0.007538335,
0.009867521,
-0.022482287,
-0.018540587,
-0.022508832,
-0.032329902,
0.02358384,
-0.030100252,
0.009469369,
0.026317814,
0.003984833,
0.009714897,
0.00450243,
0.005192559,
0.030896556,
-0.0018016355,
0.0072795367,
-0.005199195,
0.020531345,
-0.0003722302,
-0.020756966,
0.004824269,
-0.0028882574,
-0.021473637,
-0.031135447,
-0.025468424,
0.0061481227,
0.014625432,
0.00488731,
-0.0070605534,
-0.040983062,
-0.019456336,
0.007445433,
0.0031088996,
-0.016523287,
-0.007989573,
-0.007266265,
0.008314731,
-0.0043033543,
-0.008719518,
0.0041341395,
-0.02164617,
0.004917171,
0.0034805078,
-0.017837187,
0.025694044,
0.007120276,
0.008633251,
-0.0063936496,
0.00020094209,
-0.02582676,
-0.031480514,
-0.018076079,
-0.011075247,
0.027021214,
0.020159738,
0.010723547,
0.0034274207,
0.0035203227,
0.014559073,
0.0015934355,
0.0097016245,
-0.013039461,
0.016947983,
-0.000107625325,
-0.010823085,
0.011772012,
0.02087641,
-0.01078327,
0.0058163297,
-0.0068681133,
0.011446856,
-0.012150257,
-0.0016556466,
-0.014519258,
-0.006556228,
-0.018912196,
-0.0060684923,
-0.014094563,
0.03140088,
-0.05627208,
-0.012993011,
0.013590238,
-0.014519258,
0.010677096,
-0.0125683155,
-0.0004236581,
-0.0049934834,
0.023557298,
-0.0071003684,
0.0053518196,
-0.010444841,
0.0049304427,
-0.018341511,
-0.008553621,
0.008268279,
0.008819056,
0.006098354,
-0.00070630416,
0.0022213536,
-0.018022992,
0.011367225,
-0.01716033,
-0.011254416,
-0.046132486,
-0.018195523,
-0.01639057,
-0.0106173735,
-0.0018115893,
-0.022641549,
-0.021460366,
-0.0030541539,
0.0001832119,
0.027817518,
-0.0048972634,
-0.015156301,
-0.0012790617,
-0.02034554,
0.014160922,
0.0012981398,
0.016018962,
0.022628278,
-0.013696412,
-0.017465578,
0.006095036,
0.011805192,
-0.01693471,
0.031453967,
0.006270886,
-0.0237431,
-0.016908167,
0.024711937,
0.016881624,
0.026835412,
-0.023676742,
0.037134264,
0.0061016716,
-0.013205358,
-0.013437613,
-0.007777226,
-0.041248497,
0.029091602,
-0.0057366993,
-0.0049934834,
-0.00007709001,
-0.023544025,
-0.027392823,
-0.008042661,
-0.034241028,
0.006994195,
-0.011486671,
-0.015514636,
0.010232493,
0.0047844537,
-0.01206399,
0.022469016,
-0.011918002,
0.0035203227,
0.021765616,
0.010106412,
0.017956633,
-0.0047612283,
-0.01568717,
0.012044082,
-0.017717741,
0.04111578,
-0.016682548,
0.0009729827,
0.02009338,
0.015209387,
0.014041476,
-0.009011496,
-0.0053518196,
-0.022906983,
0.0021251335,
-0.0078303125,
0.016456928,
0.02081005,
-0.02776443,
-0.023769645,
-0.028799625,
-0.0021699257,
0.00084026554,
-0.00881242,
0.013165543,
-0.004346487,
-0.025415337,
-0.011413677,
0.015050126,
0.028401474,
-0.009150849,
0.0054745832,
-0.0108629,
0.023384765,
-0.025986021,
0.008998224,
0.031241622,
0.010000238,
-0.020372085,
0.00044626146,
-0.025601141,
-0.025853304,
0.014134378,
-0.0045588347,
-0.0026344357,
-0.016085321,
-0.013132364,
0.0045488807,
-0.0048806737,
-0.03774476,
0.0050034374,
0.0015884585,
0.001078327,
-0.035462026,
0.0037359882,
0.0440621,
-0.007352531,
0.030763838,
-0.0024917647,
-0.015010311,
0.00861998,
0.0021433823,
0.029011972,
0.008838964,
-0.04090343,
-0.0009945492,
-0.0002805724,
0.041938625,
-0.030684208,
0.0106372805,
-0.006191256,
0.013630053,
-0.006221117,
0.007491884,
-0.007631237,
-0.0054878546,
0.014359998,
-0.018540587,
-0.012024175,
0.017744286,
-0.024937555,
0.005467947,
0.036152158,
-0.0106173735,
-0.030657666,
0.0072397212,
-0.01964214,
0.023318406,
0.0001339614,
-0.0046948697,
-0.009456098,
-0.016602917,
-0.058183204,
0.004874038,
0.008971681,
0.022588462,
0.002629459,
0.015368648,
-0.0033594032,
0.013975117,
0.012249795,
0.038939215,
-0.02629127,
-0.01917763,
0.00674535,
-0.026742509,
0.007312716,
0.0014598889,
-0.053431932,
0.0005068137,
0.031347796,
-0.0075781504,
-0.000100678415,
0.02350421,
-0.014333454,
-0.03262188,
-0.005862781,
-0.008845599,
-0.028932342,
-0.008175378,
0.004787772,
-0.017598296,
0.0044227997,
0.009170756,
0.026410716,
0.00047861127,
-0.0067619397,
0.027844062,
0.023384765,
0.000047954443,
0.0050764317,
-0.013145635,
0.020916225,
-0.023756374,
0.019522695,
0.013052734,
0.007027374,
0.0007602205,
-0.003878659,
0.013052734,
0.0020886364,
0.017439036,
-0.00533523,
-0.020836595,
0.018514045,
-0.018686578,
0.0007577321,
0.020066835,
-0.011951181,
-0.0013180474,
-0.008533713,
-0.01422728,
-0.02327859,
-0.007266265,
0.030445319,
-0.0052688713,
-0.032966945,
0.012004267,
-0.008646524,
-0.014081291,
-0.008182013,
-0.0153951915,
0.00730608,
-0.030126797,
0.032276817,
-0.0028799626,
-0.0056570694,
0.014505986,
0.022017777,
0.0019144451,
-0.0050930213,
0.007325988,
0.19387324,
-0.02026591,
-0.002055457,
0.023066243,
0.003981515,
0.015992418,
0.014214008,
-0.0030524947,
0.008951773,
0.017027613,
-0.012628038,
-0.018155709,
-0.003186871,
0.013948574,
-0.020756966,
0.005759925,
-0.03949663,
-0.027034488,
-0.008872143,
0.017332861,
0.00045206785,
-0.007624601,
-0.000064284875,
0.00834791,
0.022415929,
0.012674489,
0.004588696,
-0.00063953083,
0.029622471,
0.004641783,
-0.013006282,
-0.01228961,
0.012926652,
0.0004707312,
-0.010458113,
-0.0013462497,
-0.002443655,
-0.00749852,
-0.0034937793,
0.025946205,
-0.010073232,
0.015315561,
-0.0082351,
-0.020650791,
-0.005806376,
0.015421735,
-0.00034610147,
-0.00637706,
-0.0072198138,
-0.0033643802,
-0.027233563,
-0.037479326,
-0.003463918,
-0.0016067072,
-0.012714305,
-0.009024767,
0.019443065,
0.007584786,
-0.032489162,
0.007511792,
0.01132741,
-0.009157484,
-0.02017301,
0.03193175,
-0.021327648,
0.037001546,
-0.01225643,
0.0011845008,
-0.00035045628,
-0.01762484,
0.011811828,
-0.0015950945,
0.009257022,
0.000310019,
-0.014107835,
-0.034771897,
0.016510015,
0.00931011,
0.031347796,
0.017492123,
-0.015912788,
-0.02752554,
-0.019735042,
-0.0033759929,
-0.030657666,
-0.031347796,
-0.015143028,
0.008328002,
-0.0055011264,
-0.00908449,
-0.0066690375,
0.011128334,
-0.017014341,
0.0025431926,
0.006788483,
0.0055442597,
0.011811828,
-0.00015179526,
-0.0144529,
-0.023690015,
-0.029542841,
0.056006644,
-0.007398982,
-0.00067312486,
-0.012667853,
-0.016337482,
-0.0049072173,
0.020624248,
0.0072330856,
0.006327291,
0.027578628,
-0.04066454,
0.006367106,
-0.017465578,
0.022615004,
0.016589645,
0.0005810523,
-0.005713474,
0.011493307,
-0.023013156,
0.0070539173,
-0.016961254,
0.0041938624,
0.013749499,
-0.034586094,
0.0011554689,
-0.017054155,
-0.0014549119,
0.014731606,
-0.02690177,
-0.013550423,
-0.030604579,
0.0037957109,
-0.00017450233,
-0.0043663946,
0.0053153224,
-0.004628511,
-0.023145873,
-0.005813012,
0.0062377066,
0.016257852,
-0.002757199,
0.002063752,
-0.015050126,
-0.008102383,
-0.023398036,
0.019031642,
0.013616782,
0.010531107,
-0.006881385,
-0.021075485,
-0.019761587,
-0.019681957,
-0.009237114,
0.029887905,
-0.012349333,
0.000831556,
-0.009562272,
0.012110441,
0.004532291,
-0.011148242,
-0.016682548,
0.053617734,
-0.010504563,
0.0042038164,
0.035382397,
-0.1677545,
0.02760517,
0.005564167,
-0.0073857103,
0.0341614,
0.008321366,
-0.00085436675,
-0.0043298975,
0.004628511,
-0.0049403966,
0.016894896,
0.03116199,
-0.0197085,
-0.00075939106,
-0.026118739,
0.0072198138,
-0.02319896,
0.015886245,
0.031029273,
0.0039217924,
0.034745354,
0.0012948219,
0.014837779,
-0.025362251,
0.008520442,
0.018686578,
-0.022402657,
-0.0037028089,
-0.0022346254,
-0.012866929,
-0.015567724,
0.021539995,
0.026410716,
-0.013603509,
-0.011645932,
0.00796303,
-0.0064301468,
-0.05590047,
-0.0061978917,
-0.010132955,
0.018288426,
0.020995855,
0.012740848,
-0.0074653407,
-0.0023358222,
0.024804838,
0.022973342,
-0.026331086,
0.022933526,
-0.0028252166,
0.008195285,
-0.0040976424,
0.019416522,
0.0076909596,
-0.016589645,
-0.001877948,
0.0011670815,
0.015567724,
0.009874158,
-0.0051195645,
-0.0276848,
-0.03612561,
0.0026609793,
0.005341866,
-0.018288426,
-0.03628487,
-0.0012666194,
-0.0056504332,
-0.0029778415,
0.005013391,
-0.027233563,
-0.013125728,
-0.0037890752,
-0.019987205,
0.02643726,
0.009409647,
-0.0011032114,
-0.016483473,
0.0024270653,
-0.0042768107,
-0.006463326,
0.015381919,
-0.016788721,
0.029303951,
0.009940516,
0.0057698786,
-0.00052174437,
0.009807799,
-0.005985544,
-0.03864724,
-0.00036704593,
-0.021712529,
0.010458113,
-0.018885653,
0.023756374,
0.044513337,
-0.023756374,
-0.0070141023,
0.017890275,
0.0019443065,
-0.009230479,
-0.0052191024,
-0.029383581,
0.0000415778,
0.018978555,
0.0059656366,
-0.006888021,
0.012030811,
0.032409534,
-0.011606116,
-0.0315336,
-0.0047081416,
0.00943619,
0.009728168,
0.012103805,
0.028428016,
-0.002383932,
-0.0033809699,
0.004817633,
-0.0008195285,
0.048149787,
-0.023530753,
-0.0008610026,
0.0019393296,
-0.028640365,
0.0012301223,
-0.113924414,
0.0048508123,
0.020212824,
-0.016005691,
-0.0210224,
0.012946559,
-0.021885062,
-0.005368409,
-0.0035899994,
0.008931865,
-0.0039715613,
-0.017558482,
-0.006516413,
-0.020040292,
0.039868236,
-0.0063073835,
0.007744047,
-0.012090534,
0.0016946323,
0.011373861,
-0.013052734,
0.0032465938,
0.0034274207,
-0.009024767,
0.0070738248,
-0.020929497,
-0.008301458,
0.016589645,
-0.0022329662,
0.009495913,
0.0108629,
-0.012090534,
-0.007080461,
-0.0054082246,
-0.0030508358,
0.017823916,
-0.028082952,
-0.017611569,
0.023092788,
-0.020836595,
0.001917763,
0.026304543,
0.017877003,
-0.0017568435,
0.017014341,
-0.02302643,
-0.031215077,
0.026888497,
0.012030811,
-0.025999293,
0.011831735,
-0.026915042,
-0.013603509,
-0.012628038,
-0.0067055346,
-0.0029877953,
-0.011347318,
0.025760401,
0.009927244,
0.0062542963,
-0.017093971,
0.0018115893,
0.004874038,
0.023822732,
0.019907575,
-0.015315561,
0.010424933,
-0.030498404,
0.015939333,
-0.011665839,
-0.011207964,
-0.0007681006,
-0.005305369,
-0.010212586,
-0.032382987,
0.019044913,
-0.030684208,
-0.02752554,
0.004396256,
-0.037293524,
-0.011732197,
0.0035734097,
0.0015386896,
-0.009960423,
0.031188535,
0.01507667,
0.004605286,
-0.007080461,
0.014094563,
0.0065761358,
0.020159738,
0.04714114,
-0.026105467,
-0.012727576,
0.040956516,
0.042469494,
-0.017492123,
-0.028242214,
-0.00036020268,
0.018540587,
-0.01485105,
-0.03540894,
-0.06949071,
0.013709683,
0.024884468,
-0.0033909236,
0.021287834,
0.010630645,
0.02420761,
0.014041476,
0.007491884,
0.021898333,
-0.040266387,
0.026450532,
-0.016191494,
-0.008673067,
-0.0052124667,
-0.0035369124,
0.0106372805,
0.010411662,
0.004359759,
0.023132602,
-0.012110441,
0.0033627213,
0.016788721,
0.039310824,
0.003326224,
-0.0047844537,
-0.00012836239,
0.03278114,
-0.005723428,
-0.000595983,
0.011254416,
0.0054745832,
-0.017903546,
-0.00091491896,
-0.00543145,
-0.010504563,
0.003603271,
-0.008288187,
0.02203105,
0.02349094,
-0.0125484085,
-0.024552675,
0.024990642,
-0.027180476,
-0.019575782,
-0.00013499825,
-0.004167319,
0.026317814,
0.0010327054,
-0.009363196,
0.024340328,
-0.004628511,
-0.0066690375,
-0.051786236,
-0.022999885,
0.0077639543,
0.011188057,
0.004442707,
0.010517836,
-0.018806022,
0.034612637,
0.02017301,
-0.001616661,
0.014014932,
0.012541772,
-0.0054015885,
-0.0018414507,
0.010099776,
0.0006374571,
-0.03447992,
-0.010856264,
-0.010079869,
-0.01031876,
0.030524949,
0.015567724,
0.0016000713,
-0.024313785,
0.02457922,
-0.007213178,
0.017930089,
0.010557651,
0.015275746,
-0.029940993,
0.012740848,
0.011851643,
0.0011911365,
-0.020531345,
0.029755188,
-0.014837779,
0.017147059,
-0.026171826,
0.025003914,
-0.007969666,
0.0141476495,
-0.00591255,
0.029197777,
0.019947391,
0.009967059,
0.02597275,
0.042469494,
-0.0009505867,
0.0025946207,
-0.016218038,
-0.048335593,
-0.0121768,
0.0035236408,
-0.025680771,
-0.016682548,
-0.0016465223,
0.005580757,
0.018354785,
0.018288426,
0.008394361,
-0.0010874512,
-0.020080106,
0.011314139,
0.0071003684,
0.01964214,
-0.015089942,
0.023716558,
0.003745942,
0.020902954,
-0.0000011486386,
-0.011831735,
0.0153553765,
-0.009688353,
0.005995498,
-0.024459774,
0.0012823796,
-0.031984836,
0.009197299,
0.0046218755,
-0.03909848,
-0.008308095,
0.01762484,
-0.010750091,
0.0474862,
0.0109093515,
0.01132741,
0.05141463,
0.012389148,
-0.015156301,
0.025481695,
0.008142198,
0.00861998,
0.03601944,
0.014877594,
-0.014638703,
-0.02467212,
0.006994195,
0.0018082714,
0.014346725,
-0.0237431,
-0.024778295,
0.030312601,
-0.0077904975,
-0.0076113297,
-0.0024901058,
0.00019067724,
0.009794527,
-0.008527078,
0.020982584,
0.002153336,
-0.006091718,
-0.006367106,
0.030206427,
0.012501957,
-0.01430691,
-0.016921438,
-0.01568717,
-0.008606709,
-0.028773082,
-0.01932362,
0.03007371,
-0.029330494,
-0.016961254,
0.0077506825,
0.016881624,
-0.0055608493,
0.0119246375,
0.01302619,
-0.017425764,
0.0028666907,
0.0039616073,
-0.02411471,
0.006556228,
-0.014426356,
-0.022893712
] |
PTH binding to its receptor activates protein kinase A (PKA), protein kinase C (PKC), and calcium signaling to induce transcription of primary response genes in osteoblasts. Adenovirus E4 promoter-binding protein/nuclear factor regulated by IL-3 (E4BP4/NFIL3), a transcriptional repressor, is a PTH-induced primary response gene in primary mouse osteoblasts (MOBs). Here we investigate the signaling pathway(s) that lead to PTH induction of E4bp4 mRNA expression. Ten and 100 nm PTH induced maximum E4bp4 expression in MOBs. | [
-0.024491148,
-0.027505241,
-0.02454334,
-0.041962456,
-0.016975483,
0.020563692,
-0.026552735,
0.0036208276,
-0.021255236,
0.013817861,
0.012643538,
0.0059727347,
0.0010381336,
-0.006096691,
-0.012943643,
-0.00038287806,
0.023577785,
-0.018958785,
-0.00850079,
0.02532622,
-0.021503149,
0.011488788,
0.010294894,
-0.0066055637,
0.0058520404,
0.0057541803,
0.0025818783,
-0.036612764,
-0.012800115,
-0.02631787,
0.011547504,
0.019780809,
-0.014848655,
0.019010976,
-0.00767224,
-0.0074438998,
-0.014496358,
-0.017105963,
0.016505755,
0.0059825205,
0.017445212,
-0.0058879224,
0.022507846,
0.0013194818,
-0.0019604662,
-0.02329073,
0.035073098,
-0.01409187,
-0.024308475,
0.02831422,
-0.01409187,
0.009942597,
0.015357528,
0.01349166,
-0.007626572,
0.0045570238,
0.03319418,
0.02090294,
0.0045178793,
-0.021346573,
-0.010816814,
-0.01945461,
-0.026552735,
0.0058585643,
-0.00045994297,
0.0065664197,
0.009936073,
0.012199906,
-0.0027319307,
0.0061130007,
0.024047514,
0.016414419,
-0.018867448,
-0.0020844224,
0.021633629,
-0.025652422,
-0.025104405,
0.006122787,
-0.010634142,
0.008885707,
0.023656074,
-0.022990623,
-0.011143016,
0.024112755,
0.003350081,
-0.0029863673,
-0.011886753,
0.017810557,
0.0023062387,
0.0014899216,
0.031263072,
0.011691033,
0.013909197,
0.020263586,
-0.025443653,
0.018436862,
0.027218185,
0.0343946,
-0.007620048,
-0.023303777,
-0.00086850935,
-0.002379634,
-0.01700158,
-0.010536282,
-0.038596064,
0.008840038,
-0.0234734,
-0.006220647,
0.0132307,
-0.016127361,
-0.04590296,
0.046790227,
-0.002849363,
-0.028262027,
0.02891443,
-0.009896928,
0.009551156,
-0.0043417313,
0.00031723015,
0.0002140692,
0.02758353,
0.0383612,
-0.010197033,
-0.012226001,
0.014822559,
0.00677845,
0.0035914695,
-0.02639616,
-0.013596045,
0.0034544652,
0.0135569,
-0.0022002235,
0.015527152,
-0.0017256016,
-0.03413364,
0.0032897338,
-0.020942084,
-0.03896141,
-0.02553499,
-0.037682705,
0.007019839,
0.013452516,
-0.009094475,
-0.012871879,
0.0026226535,
0.015422768,
0.01329594,
-0.015227048,
0.009649016,
0.0063837473,
-0.013387276,
-0.016701475,
0.002855887,
0.013374228,
-0.013517756,
-0.0096816365,
-0.0040383646,
0.04621611,
0.003320723,
-0.04136225,
0.01180194,
-0.019389369,
-0.0034512032,
0.010164414,
0.011208256,
0.020133106,
0.022207743,
-0.0013594413,
0.0039209323,
-0.015722873,
-0.007946249,
0.004204727,
-0.03742174,
0.00929672,
0.0037415219,
0.0041786307,
-0.021464005,
0.0079919165,
0.00067360443,
-0.0064261532,
-0.025078308,
-0.011071251,
0.032019857,
0.011286544,
-0.019219745,
-0.006559896,
0.029358061,
-0.03496871,
-0.01844991,
-0.009172764,
0.005780276,
0.0014695341,
-0.0045537613,
0.0004587197,
-0.6425893,
-0.01054933,
0.011384404,
-0.0003284433,
0.0017288636,
0.033115894,
0.0018120448,
-0.013687381,
-0.011847609,
0.018802207,
-0.020093963,
0.014378926,
0.007854912,
-0.023643026,
-0.015187904,
-0.03008875,
-0.009799069,
-0.016818907,
0.035281867,
0.0014181575,
-0.01931108,
-0.015135712,
0.014744271,
0.030584576,
0.01396139,
0.02235127,
0.0114105,
-0.03136746,
-0.0015584237,
0.038857024,
-0.0011612744,
0.042640954,
0.003408797,
0.021933734,
0.046790227,
-0.011384404,
-0.013132839,
0.026383111,
-0.0011074513,
0.03538625,
-0.017510453,
-0.014509406,
0.016323082,
0.010758098,
-0.022834048,
0.03199376,
-0.003294627,
0.011664936,
0.0004986793,
0.0005427164,
0.008285497,
0.00073966006,
-0.02049845,
-0.0022426296,
0.00859865,
0.003392487,
0.017092915,
-0.012473914,
0.016910244,
-0.0073917075,
0.013015407,
0.023251584,
-0.0054703853,
-0.013400324,
0.00046646697,
-0.0027254068,
-0.00780272,
0.0068371664,
0.004808198,
0.0075221877,
0.028810045,
0.031706706,
0.011664936,
0.0025199002,
0.010823338,
0.012180334,
0.014509406,
0.0063739615,
-0.0022312126,
0.012643538,
-0.019819954,
0.011684508,
-0.037395645,
0.009733829,
0.033037607,
0.011169111,
-0.038048048,
0.01818895,
0.015762016,
-0.008102825,
0.009518536,
-0.014705127,
-0.025678517,
-0.02917539,
-0.014718175,
0.017680077,
0.0029700573,
0.0068697864,
0.0030287732,
-0.0153836245,
-0.027426954,
0.010053505,
-0.017980183,
-0.0020191823,
0.022442607,
-0.010627618,
-0.03491652,
-0.0063087214,
0.042484377,
-0.01693634,
0.0018267238,
-0.0145355025,
-0.008089777,
-0.018906591,
0.0015983833,
-0.024321523,
0.028653469,
0.0145355025,
-0.011756273,
0.002831422,
0.018241143,
-0.016127361,
0.0019881933,
-0.00036616027,
0.020407114,
0.017823605,
0.0068306425,
-0.019063167,
-0.01646661,
0.009570728,
-0.0093293395,
-0.00655011,
0.023982273,
-0.014378926,
0.025013069,
0.00936196,
0.025822045,
0.012884927,
0.018841352,
-0.03650838,
-0.02030273,
0.0002523978,
0.001432021,
0.0025606754,
0.0054638614,
-0.01415711,
-0.008311593,
0.02156839,
0.013857005,
0.014000533,
0.008983566,
-0.012858831,
0.0072873235,
0.009805593,
0.02222079,
-0.01422235,
-0.014196253,
-0.006687114,
-0.0061195246,
-0.019885194,
0.003359867,
0.0141179655,
-0.012617443,
-0.0022312126,
-0.0058520404,
-0.01540972,
-0.0064228913,
0.018358575,
0.007946249,
-0.03397706,
0.011586648,
-0.009159715,
-0.01792799,
0.010849435,
0.00003901666,
0.010086125,
-0.0015861508,
-0.018997928,
-0.005809634,
-0.0026748455,
-0.0064326776,
-0.021998974,
-0.01128002,
-0.015657634,
0.033481237,
0.009968692,
0.0049680364,
0.010914675,
0.01454855,
0.013067599,
-0.030532384,
0.03663886,
-0.018528199,
0.027505241,
0.02857518,
-0.048695236,
0.030741153,
0.013948341,
0.012539154,
0.021894589,
0.0010683072,
-0.0055976035,
0.0290971,
-0.010294894,
0.017223395,
-0.012878403,
-0.009087951,
-0.020420162,
0.022403464,
-0.0005182513,
-0.0069285026,
-0.0034870852,
0.0013415003,
-0.01540972,
-0.003343557,
0.0055878176,
-0.013674333,
0.005232259,
-0.00088237284,
-0.025508894,
0.007169891,
0.0071307467,
0.0264614,
0.01246739,
-0.015840305,
0.026422255,
0.015187904,
0.013700428,
0.015709825,
0.00481146,
-0.02103342,
0.0018593438,
0.016831955,
-0.0026405945,
-0.008292021,
-0.017693125,
0.01700158,
0.008937899,
0.011312639,
0.006034713,
-0.0013716739,
0.02156839,
-0.007965821,
-0.009433724,
-0.014639887,
-0.013054552,
0.013726525,
-0.0051278747,
-0.025587182,
0.040788133,
0.0014646411,
0.023029769,
-0.005767228,
0.021529244,
0.006302197,
0.0016367119,
0.0058487784,
0.03215034,
0.047025092,
0.020981228,
0.022116406,
0.005731346,
0.01859344,
-0.015618489,
0.015161808,
0.01706682,
0.0059531624,
-0.0091140475,
-0.010053505,
-0.015187904,
-0.03444679,
0.012617443,
0.01250001,
-0.033324663,
0.010784195,
-0.0050724205,
0.01739302,
0.020563692,
0.0012705517,
0.0077831484,
-0.0023502759,
-0.02771401,
0.017366925,
0.01812371,
-0.021881541,
-0.01227167,
-0.021594485,
-0.02130743,
-0.018019326,
0.0029260202,
-0.011266972,
-0.0098904045,
0.00390136,
0.0023046078,
-0.01931108,
-0.00580311,
0.022377366,
0.0005325226,
0.022520896,
-0.0066708038,
0.0058911843,
0.002771075,
-0.019898241,
-0.014731223,
0.03849168,
0.009218431,
0.012604394,
-0.016740618,
-0.0079919165,
-0.03486433,
0.012741399,
0.00050438783,
-0.0033044128,
-0.028340315,
-0.011697557,
0.0073851836,
0.0025704615,
0.00770486,
0.024765156,
-0.0040938184,
-0.027609626,
-0.011338736,
-0.011201732,
-0.014757319,
0.009035759,
0.017562645,
0.009844736,
0.0058911843,
-0.020420162,
0.019637281,
-0.017575692,
-0.032333013,
0.0064359396,
0.0034348932,
0.019532897,
0.020263586,
0.0017680078,
0.017836653,
-0.008057157,
0.014861703,
0.01396139,
-0.035803787,
0.005643272,
-0.010066553,
0.0105232345,
-0.0030989065,
0.026774552,
0.03055848,
0.013661285,
-0.005829206,
-0.0055519356,
0.040187925,
0.001648129,
-0.023408161,
0.0032424347,
0.016244793,
0.015396672,
-0.00754176,
0.006791498,
-0.032045957,
-0.010758098,
0.015305336,
-0.00027992096,
0.026435303,
0.012526106,
0.02546975,
0.022873191,
-0.01771922,
-0.001911536,
-0.0017272326,
0.014131013,
0.00027237757,
0.017836653,
0.005176805,
0.02109866,
-0.016414419,
-0.025574133,
-0.011325688,
-0.0022670948,
-0.0036110415,
-0.0044069714,
-0.016975483,
0.014900847,
-0.011788893,
-0.019193647,
-0.011684508,
0.021672774,
-0.025091356,
0.008683463,
-0.0025606754,
-0.00833769,
-0.013674333,
0.014209302,
0.007306895,
-0.0029423302,
-0.029749501,
-0.039378945,
0.004922368,
0.017640933,
0.014196253,
0.00968816,
0.002413885,
0.0076852883,
0.015631536,
-0.037526127,
-0.020133106,
-0.014835607,
-0.030741153,
0.00388505,
-0.008070205,
0.021046469,
-0.011938945,
0.0064848694,
-0.015292288,
0.007150319,
-0.010575426,
0.029540734,
-0.005747656,
-0.010255749,
0.019167552,
0.0155923925,
0.015501057,
0.007972345,
-0.0011237614,
-0.01081029,
-0.027557435,
-0.02096818,
-0.030323615,
-0.001927846,
0.010979915,
0.016062122,
0.014078821,
-0.027009416,
-0.025952527,
-0.00089460536,
-0.0031184785,
0.007306895,
0.0070589827,
0.022964528,
0.0390136,
-0.0010944033,
0.009988265,
0.0038915742,
-0.006752354,
0.008787846,
-0.00092885643,
0.022638327,
-0.019545944,
-0.036664955,
-0.010210081,
0.018945735,
-0.008135445,
-0.012930595,
0.007633096,
-0.021398764,
0.03021923,
0.010888578,
-0.018371623,
-0.032254722,
0.024530292,
-0.029671215,
-0.004420019,
0.011906325,
-0.0066023017,
-0.0072286073,
-0.002441612,
0.008918326,
-0.004318897,
-0.0016416049,
-0.03136746,
-0.0153836245,
-0.0068697864,
0.0023062387,
-0.0015885973,
0.0008383358,
-0.0026487496,
-0.009675113,
-0.0018430338,
-0.019650329,
-0.052035533,
-0.0057835383,
-0.022077262,
0.015775066,
0.0128523065,
0.03465556,
-0.0075874277,
0.0055454117,
0.030323615,
0.008207209,
0.009309768,
-0.004400447,
0.0069089304,
-0.019271936,
0.0145355025,
0.0012248836,
-0.020054817,
0.047860164,
-0.0049647745,
0.013178508,
0.011129967,
-0.029201485,
-0.0130610755,
0.0112995915,
-0.020002626,
-0.029018812,
0.02560023,
-0.025443653,
0.008918326,
-0.016923292,
0.00027665895,
0.02995827,
0.00373826,
0.007502616,
-0.014313686,
-0.0020550643,
-0.029123196,
0.007978869,
-0.019389369,
-0.004191679,
-0.008853086,
-0.0068828342,
0.0033990112,
0.0106667625,
0.026304822,
0.006064071,
0.014065773,
-0.014509406,
-0.0014744271,
-0.014391975,
-0.0030597623,
-0.01389615,
0.0058911843,
-0.04021402,
-0.008892231,
-0.008657366,
-0.009309768,
-0.006850214,
-0.04371089,
-0.0024709702,
0.032907125,
-0.022677472,
0.020028722,
0.0024791253,
-0.012441294,
0.04371089,
-0.0011710605,
0.030767249,
-0.009629444,
0.030114846,
0.024726013,
0.012956691,
-0.0025313173,
-0.018397719,
-0.008128921,
0.007346039,
0.027165992,
0.006067333,
0.004358041,
-0.035281867,
-0.011997662,
0.018671727,
-0.016127361,
-0.0093293395,
0.028862236,
-0.027818395,
-0.01659709,
0.007763576,
0.004661408,
-0.004857128,
-0.0060771187,
-0.022312127,
0.008455122,
-0.0031233716,
-0.005046325,
-0.025130501,
0.018606488,
-0.0030369284,
0.02308196,
0.0030092013,
-0.0383612,
0.00058756897,
-0.0069219787,
0.018697822,
0.019024024,
-0.012571774,
0.01859344,
0.0011547505,
0.0010259012,
0.010510186,
0.0028248979,
0.006034713,
-0.013152411,
-0.0069545987,
0.036482286,
0.006331555,
-0.0036599718,
0.0043449933,
0.0058618262,
-0.0041166525,
-0.0010128531,
-0.008455122,
-0.008970519,
-0.02792278,
0.01706682,
0.036821533,
0.007881008,
-0.026278727,
0.0007906289,
-0.028888332,
0.01501828,
-0.031524032,
0.0018332478,
-0.002376372,
-0.04908668,
-0.021450957,
0.0011270234,
0.01342642,
0.018645631,
0.018567342,
0.0123564815,
0.006706686,
0.018436862,
-0.019833002,
0.01984605,
0.009577252,
0.020511499,
-0.03121088,
-0.012128142,
-0.020811604,
-0.024164947,
0.010412326,
-0.0188544,
-0.009923025,
-0.00014984843,
-0.014939992,
0.016779764,
0.023225488,
-0.018554294,
0.04595515,
-0.0022785119,
0.020459307,
0.0133416075,
0.013374228,
-0.004260181,
-0.00661535,
0.006161931,
0.0158664,
0.020054817,
-0.016101265,
0.005284451,
-0.010027409,
0.006625136,
-0.010210081,
-0.018541247,
-0.009244528,
0.024021419,
-0.019519849,
-0.014248446,
-0.014248446,
-0.0065011797,
-0.026539687,
0.021920687,
0.007535236,
-0.0074504237,
-0.019206697,
0.03121088,
0.0019555732,
0.0037806658,
-0.022990623,
0.0023013458,
0.009433724,
-0.03400316,
-0.018736968,
0.0072873235,
-0.021346573,
0.025482798,
-0.0002116227,
-0.014966087,
-0.018019326,
-0.0129175475,
-0.027948875,
-0.017445212,
-0.016871098,
-0.0011824775,
-0.000060245187,
-0.008526886,
-0.0068110703,
0.0017892107,
0.00013527134,
0.010705907,
-0.013400324,
-0.008089777,
0.000477884,
-0.01461379,
0.009596824,
0.033481237,
-0.023303777,
-0.0045211413,
0.03676934,
-0.021150852,
-0.014626838,
0.03645619,
-0.020289682,
0.018802207,
-0.022755759,
0.0116518885,
0.008194162,
0.022977576,
0.03823072,
-0.05266184,
0.0044754734,
0.024895636,
0.0077505284,
-0.016544899,
-0.0020599572,
-0.008539934,
0.016349178,
0.006700162,
-0.0026797387,
-0.033742197,
0.007274275,
-0.0010348717,
0.026696265,
0.031602323,
-0.0004248764,
0.010405802,
0.0039926963,
-0.013530805,
-0.018110663,
0.0019620971,
-0.023095008,
0.0028248979,
0.012389102,
-0.0034903474,
-0.01838467,
0.0004065276,
-0.012650062,
-0.031263072,
0.013752621,
0.008070205,
-0.024047514,
-0.021503149,
0.013700428,
0.01799323,
-0.023003671,
-0.025743758,
-0.023864841,
-0.008513838,
-0.032489587,
-0.0014148954,
-0.0111560635,
-0.012062902,
-0.016049074,
0.020159202,
-0.0075287116,
0.0029733193,
0.008605174,
-0.013374228,
-0.017510453,
0.021724965,
0.18517761,
-0.008350737,
-0.002823267,
0.0054834336,
-0.009251052,
0.018345527,
-0.0009141774,
0.0055030053,
-0.0012420091,
-0.018436862,
0.020668074,
0.016740618,
0.0032326488,
-0.0008513838,
-0.0040579364,
-0.034498986,
-0.00770486,
0.0036045176,
-0.022807952,
-0.013008883,
0.015005232,
-0.003278317,
0.010471042,
0.0048669144,
0.026109103,
0.016792811,
-0.04522446,
0.0025394724,
0.03478604,
0.015305336,
-0.028340315,
0.022677472,
0.0031657775,
0.004625526,
0.0058618262,
0.006488132,
0.00850079,
-0.011090823,
0.0070002666,
-0.0066381837,
0.0065468475,
0.0135569,
-0.03029752,
-0.0065142275,
0.008513838,
-0.0050528487,
0.0045309276,
-0.021646677,
-0.021803254,
0.022573087,
-0.027348666,
0.005695464,
0.006184765,
0.015096568,
-0.0033859632,
-0.041492727,
-0.0037317357,
0.01924584,
-0.004951726,
0.007822293,
0.01061457,
0.0049908706,
-0.021672774,
0.021281332,
-0.026957225,
0.027896682,
-0.01074505,
-0.0015983833,
0.01514876,
-0.016414419,
-0.004361303,
0.02030273,
0.015422768,
-0.0048767,
-0.019872146,
-0.020863796,
0.019885194,
0.018567342,
0.022638327,
0.01035361,
0.005571508,
0.006817594,
-0.025887286,
-0.0019963481,
-0.013276367,
-0.01891964,
0.024582483,
0.011116919,
-0.011997662,
0.0016897195,
0.018201998,
-0.013413372,
-0.0191806,
0.01924584,
0.019545944,
-0.0039666,
-0.013041504,
0.0031869807,
-0.02784449,
0.009381532,
-0.016036026,
0.08366395,
0.004289539,
0.00020397737,
-0.00671321,
0.0013219282,
0.002387789,
0.009551156,
0.004749482,
-0.010340562,
0.021346573,
-0.0124934865,
0.00003009711,
-0.009968692,
-0.0004954173,
-0.01134526,
0.0009940966,
-0.020381019,
0.018736968,
-0.017706173,
-0.017145108,
-0.028131546,
0.0018071518,
0.02446505,
-0.02334292,
0.013034979,
-0.0026830006,
0.000595724,
0.000059531623,
-0.021607533,
0.005277927,
0.009766448,
-0.0010152996,
0.018528199,
-0.0051572328,
0.014913895,
0.0091140475,
-0.012682683,
-0.017614838,
0.034812137,
0.0058879224,
-0.010112221,
0.028209835,
0.0124934865,
-0.0058977082,
-0.01871087,
0.013778717,
0.011501836,
-0.01745826,
0.024986973,
-0.02374741,
-0.0071307467,
0.0014507775,
-0.016114313,
0.013315512,
-0.0026340706,
-0.016427467,
-0.03716078,
0.01685805,
-0.0069676465,
-0.021529244,
-0.0031592536,
0.0017337566,
-0.008624746,
-0.00885961,
0.0026242845,
-0.1634657,
0.0073851836,
0.012976264,
-0.032959316,
0.022494799,
0.013335084,
0.00199961,
-0.010966867,
-0.008703034,
-0.01144312,
0.032228626,
0.013048028,
-0.023616929,
-0.025482798,
0.0022768807,
-0.007600476,
-0.0044526393,
0.012258622,
0.012878403,
0.0055584596,
0.0060216645,
-0.004716862,
0.013074123,
-0.011129967,
0.01422235,
0.009942597,
0.027139897,
-0.015879449,
0.00044159417,
-0.009205383,
-0.02467382,
0.02460858,
-0.01568373,
-0.0035164433,
0.02070722,
-0.020381019,
0.01508352,
-0.023917034,
0.00072742754,
0.030662864,
0.01958509,
0.0074960915,
-0.0073395153,
0.0034479413,
-0.0045700716,
0.010973391,
-0.003839382,
0.004782102,
0.035047002,
-0.014874751,
0.016453562,
-0.01396139,
0.010268797,
0.043502122,
0.02797497,
0.003751308,
0.0038785262,
0.005799848,
-0.011064727,
-0.008233305,
-0.014196253,
-0.0070655067,
0.02870566,
-0.021137804,
-0.0022605706,
-0.027035512,
0.0027743368,
0.03102821,
-0.0290971,
0.0032685308,
-0.02334292,
-0.044024043,
0.012871879,
-0.010281846,
0.021920687,
0.024517244,
-0.005153971,
0.010816814,
-0.0059694727,
0.008442074,
0.004720124,
0.01147574,
-0.033559527,
-0.012774019,
-0.021424862,
-0.0010006205,
0.015448865,
0.045511518,
0.0040709847,
-0.01253263,
0.010790719,
-0.025417557,
-0.00046524373,
0.0015616858,
0.035490636,
0.015579345,
0.0051343986,
-0.019324128,
-0.014457215,
0.019637281,
0.047781877,
-0.02368217,
0.0031005375,
0.017653981,
0.025274029,
-0.014209302,
-0.011312639,
0.0050593726,
0.043502122,
-0.0030320354,
-0.0028428389,
0.000017303926,
0.0013651499,
0.026957225,
-0.0029309131,
0.023629978,
-0.005724822,
0.004305849,
0.0017663767,
-0.032176435,
0.050965596,
0.028157642,
-0.009368484,
0.039848674,
-0.016009929,
-0.03340295,
-0.12787066,
-0.018097613,
0.008918326,
0.01958509,
-0.014809511,
0.011619268,
-0.002348645,
0.026748456,
-0.0022409987,
0.034759946,
-0.029123196,
-0.020263586,
0.017275589,
0.004772316,
0.021972878,
0.0010935878,
0.020602835,
-0.01501828,
-0.030010464,
0.041701496,
0.00061611156,
-0.008252878,
0.015135712,
-0.00060754875,
0.005708512,
-0.0033827012,
-0.033742197,
0.0013039872,
0.001147411,
0.0129893115,
0.0033827012,
-0.01167146,
0.026239583,
0.0060575465,
-0.03486433,
-0.0042471327,
-0.0059564244,
0.007907105,
0.04136225,
-0.0015143866,
0.029592926,
-0.00939458,
0.012813163,
-0.01081029,
-0.00054801715,
-0.005046325,
-0.0416754,
-0.006328293,
0.02672236,
0.00031661853,
-0.021985926,
-0.030767249,
-0.030323615,
0.013015407,
0.025039164,
-0.0068436903,
0.0049615125,
0.032959316,
-0.008676938,
0.01812371,
-0.0021871757,
-0.014809511,
-0.011077776,
-0.0039470284,
0.02103342,
-0.016897196,
-0.010001313,
-0.04663365,
0.02459553,
0.0025737234,
-0.00052559085,
0.008644318,
0.00385243,
0.01409187,
-0.018397719,
0.008644318,
-0.023238536,
-0.024478098,
0.0017092916,
-0.013211127,
-0.010373182,
-0.012382578,
0.016557947,
-0.021777157,
0.012428246,
0.0077505284,
0.0051213508,
-0.004286277,
0.0070981267,
-0.025835095,
-0.041858073,
0.013857005,
-0.0000744655,
0.0036599718,
-0.006719734,
0.0129893115,
-0.015775066,
-0.0032522208,
0.016036026,
0.0047070757,
-0.021659726,
-0.039405044,
-0.05934243,
0.016740618,
0.0072677513,
-0.0058487784,
0.010562378,
-0.016740618,
0.020889891,
-0.012832735,
-0.013387276,
-0.015253144,
-0.016505755,
-0.0053660013,
-0.018554294,
-0.0010552593,
-0.0068893586,
0.005793324,
0.019637281,
-0.025052212,
0.014248446,
0.025300125,
-0.01501828,
-0.0091140475,
0.02368217,
0.007711384,
-0.001193079,
-0.019219745,
-0.019363273,
0.020720268,
-0.028366411,
0.0073590875,
0.0027449788,
-0.063517794,
-0.005838992,
-0.0069611226,
-0.014248446,
-0.021203045,
-0.021477053,
0.025574133,
0.022507846,
0.017980183,
-0.005796586,
-0.031184785,
0.0060869046,
-0.017027676,
0.033324663,
-0.006292411,
-0.04089252,
-0.0064685596,
-0.00655011,
-0.027505241,
0.026513591,
-0.0015094937,
0.00786796,
-0.020720268,
-0.022494799,
0.010979915,
-0.017523501,
-0.01051671,
0.017040724,
-0.019089265,
0.0090488065,
0.020276634,
0.013713477,
-0.0065664197,
0.01329594,
0.0036762818,
-0.011449644,
-0.011423548,
0.0027890159,
-0.010340562,
-0.03235911,
-0.0025296863,
0.014131013,
0.008239829,
0.014822559,
0.013582996,
0.00032518132,
0.013739573,
-0.032828838,
-0.0014980766,
0.011854133,
-0.010249225,
-0.011064727,
0.00038430517,
0.0337161,
0.008376834,
-0.015070472,
0.020889891,
0.009812117,
0.011834561,
-0.00377088,
0.010073077,
0.011612744,
0.020942084,
0.024778204,
0.01607517,
-0.018084565,
0.0034772994,
-0.007117699,
0.034420695,
0.006181503,
-0.013648236,
-0.004168845,
-0.02493478,
-0.023095008,
0.023460353,
-0.03162842,
-0.04292801,
-0.017053772,
0.004791888,
0.0017680078,
0.001924584,
0.004283015,
0.011775845,
-0.0068436903,
0.017079867,
-0.0072612274,
-0.004733172,
0.0045831194,
0.03987477,
0.013635188,
0.0104579935,
-0.0063674375,
-0.0072286073,
0.011175635,
-0.005643272,
0.035568923,
-0.0065044416,
0.00482777,
-0.024360668,
-0.0037774039,
0.00045953522,
-0.01633613,
-0.005695464,
0.006948075,
-0.0178497,
-0.020759411,
0.03718688,
-0.007711384,
0.0893007,
0.010464518,
-0.018554294,
0.0006364991,
-0.0125652505,
0.023577785,
-0.0034185832,
0.0155923925,
-0.0060216645,
-0.033220276,
0.013439468,
-0.035334058,
0.013008883,
-0.05106998,
-0.0065174894,
0.011462692,
0.008350737,
0.008866135,
-0.010203557,
-0.0034414171,
-0.0009068379,
0.0027792298,
-0.0037154257,
0.01812371,
-0.033820488,
0.01547496,
0.031184785,
0.008853086,
0.0010046981,
-0.03987477,
-0.0099621685,
-0.00043507016,
-0.033950966,
0.009909977,
0.012128142,
-0.027766202,
-0.021346573,
-0.016845003,
0.016323082,
0.026774552,
-0.01646661,
0.021646677,
-0.012167285,
-0.031967666,
0.015905546,
0.0056530577,
-0.011319163,
-0.012911023,
-0.013289416
] |
Kidney donor exchanges enable recipients with immunologically incompatible donors to receive compatible living donor grafts; however, the financial management of these exchanges, especially when an organ is shipped, is complex and thus has the potential to impede the broader implementation of donor exchange programs. Representatives from transplant centers that utilize the National Kidney Registry database to facilitate donor exchange transplants developed a financial model applicable to paired donor exchanges and donor chain transplants. The first tenet of the model is to eliminate financial liability to the donor. Thereafter, it accounts for the donor evaluation, donor nephrectomy hospital costs, donor nephrectomy physician fees, organ transport | [
-0.004304734,
-0.022256674,
0.024615616,
-0.021630289,
-0.006950213,
0.019151403,
-0.015979493,
0.004844492,
-0.021510342,
-0.019951044,
-0.00819632,
0.0072034327,
0.010128786,
-0.0034351244,
-0.007976419,
-0.0047445367,
0.025908368,
-0.026108278,
0.002848721,
-0.027081175,
-0.028760422,
-0.010128786,
-0.03470442,
0.024748888,
-0.011574804,
0.021790218,
0.029133586,
-0.016206058,
0.007876464,
-0.030572942,
-0.016712496,
0.008995961,
-0.02801409,
-0.009595692,
0.009649001,
0.0043747025,
0.0049244557,
-0.001639264,
0.023842629,
-0.008922661,
0.03726327,
0.0022373288,
-0.01825847,
0.017485483,
-0.010115459,
0.015779583,
-0.0058073928,
-0.026521426,
-0.02886704,
0.002683795,
-0.005410904,
0.009415773,
-0.018085213,
0.009089253,
-0.014580121,
-0.006150572,
0.0007888125,
0.008609468,
-0.010182096,
-0.025068745,
-0.012554363,
0.017112317,
-0.026374826,
0.019151403,
-0.019684495,
0.0017558783,
0.0145934485,
-0.00837624,
-0.0060339575,
-0.006497083,
0.030919451,
0.020444155,
-0.008476195,
0.0031052725,
0.0038815907,
-0.016965717,
0.011135001,
0.023296207,
-0.029426789,
0.011834687,
0.00507772,
-0.045499574,
-0.014580121,
0.017338883,
0.010768498,
-0.014753376,
0.018538345,
0.014326901,
0.02232331,
-0.00008277534,
0.02097725,
0.040648416,
-0.006433778,
0.011254947,
-0.0034317926,
0.018338434,
0.021457033,
0.01664586,
0.008096365,
-0.027321067,
-0.0021640284,
0.023056315,
-0.029746644,
-0.011201638,
-0.049177922,
-0.0071634506,
0.01312744,
-0.02489549,
0.019098092,
0.005787402,
-0.016725823,
0.049417812,
-0.0005268468,
0.008975971,
0.011081692,
-0.024482341,
0.01553969,
-0.015299798,
-0.0033784832,
-0.030892797,
0.02424245,
0.0011811364,
0.006317164,
-0.023909265,
0.025255328,
0.017019026,
-0.020684047,
0.0063204956,
-0.025255328,
-0.007236751,
-0.0059706527,
-0.00041564673,
0.0017408851,
0.04155468,
-0.022096746,
0.017365538,
-0.028200673,
0.0028353937,
-0.01202127,
-0.031879023,
0.008596141,
0.0235361,
-0.0068302667,
-0.000100215424,
-0.016712496,
0.025415257,
0.00819632,
0.006373805,
0.027427686,
-0.0021773558,
-0.0033335034,
-0.0017059008,
0.02001768,
-0.02223002,
0.0026538086,
0.009329145,
0.015899528,
0.009815593,
-0.002890369,
-0.016139422,
-0.03278528,
-0.027747542,
0.0015459725,
0.00070010236,
0.009109244,
0.010255395,
-0.014606776,
0.02846722,
-0.007549944,
-0.021710252,
-0.0041681286,
0.01448683,
-0.018671617,
0.015846219,
0.018071886,
0.0059773163,
-0.0005510026,
0.0072833966,
-0.059919763,
-0.031612474,
0.009502401,
0.017325554,
0.00083962304,
0.024708906,
-0.010701862,
-0.026041642,
0.005290958,
-0.012787593,
0.008536167,
-0.0047212136,
0.00028716275,
0.0051610162,
-0.00052767975,
-0.011048373,
-0.64909524,
-0.023855956,
0.017112317,
-0.019284675,
-0.0005222655,
0.01925802,
0.007476643,
0.014353556,
-0.025281982,
0.01312744,
-0.013080794,
0.0250954,
0.007909782,
-0.020790666,
-0.008736078,
-0.022003455,
0.01639264,
-0.017818667,
0.036143772,
0.005164348,
0.009315818,
0.01488665,
0.0011286599,
0.021350415,
0.0009079257,
0.009015952,
0.020044334,
0.0006967705,
-0.008769397,
-0.025521874,
-0.0020257572,
0.009982185,
-0.0155130355,
-0.002750432,
0.058107246,
0.005644133,
0.0004777022,
0.0011961296,
-0.010455306,
0.017472155,
-0.0047911825,
-0.019631187,
0.019684495,
0.01971115,
0.00536759,
0.011135001,
0.031212654,
-0.014020372,
0.0026071628,
0.0031535842,
0.015473053,
0.009269172,
-0.021150505,
0.019018129,
0.008036392,
-0.003668353,
0.009222526,
-0.0148999775,
0.023216244,
0.008622795,
-0.012894211,
0.0044579986,
-0.009375791,
-0.036730178,
-0.003938232,
0.0051610162,
-0.013500606,
0.028947003,
0.0153930895,
-0.007836482,
0.00988223,
0.02424245,
-0.0033668217,
0.007276733,
0.030253084,
0.0131474305,
0.000051096853,
-0.012640991,
-0.01755212,
0.019191384,
-0.02061741,
0.005151021,
-0.012514382,
-0.010581916,
0.0473654,
-0.004114819,
-0.004141474,
0.007896455,
0.014446847,
0.010715189,
0.018111868,
-0.00409816,
-0.0074499887,
-0.04038187,
-0.0120412605,
0.0017508806,
-0.007823154,
0.0071834414,
0.009329145,
-0.015632981,
-0.011035046,
-0.0069435495,
0.006793617,
-0.0033801491,
-0.0070368405,
0.0049677696,
-0.057200987,
0.025761768,
0.059120122,
-0.030359702,
-0.013587234,
-0.023949249,
-0.0048245005,
-0.014540139,
0.015326452,
-0.02453565,
0.018391743,
0.0020107639,
0.0031185998,
-0.04275414,
0.02645479,
0.0061439085,
0.01769872,
-0.023109624,
0.019524567,
0.012780929,
-0.0065503926,
-0.032065604,
0.006803612,
0.010115459,
0.01468674,
-0.021363743,
0.0002879957,
0.0037283262,
0.025988333,
-0.023229571,
-0.008442876,
0.009222526,
-0.0025521875,
-0.023202917,
0.0005410071,
-0.024682252,
0.015766256,
-0.0058373795,
0.003565066,
0.0027237772,
-0.0081096925,
-0.01149484,
0.010575253,
-0.03323841,
-0.001148651,
-0.022576531,
-0.03574395,
0.0068969037,
-0.0011161655,
-0.0072967242,
-0.0009145894,
-0.021110522,
-0.017578775,
-0.0030702883,
0.0035717299,
0.010708526,
-0.036890104,
0.020790666,
-0.0075765983,
-0.025002109,
0.00035671485,
-0.007563271,
-0.017525464,
-0.01991106,
-0.016219385,
-0.010062149,
-0.013560578,
0.025281982,
0.006950213,
-0.02685461,
0.008229638,
-0.032971863,
0.028680457,
0.013187413,
0.0008142178,
-0.022843078,
-0.011421539,
-0.009728965,
0.011728068,
0.014740049,
0.00032547888,
0.018418398,
-0.0003946145,
0.025162037,
-0.01169475,
0.001291087,
-0.0016817449,
-0.0012227844,
0.0038382767,
-0.0051343613,
-0.02107054,
-0.00063554797,
0.011421539,
0.02433574,
0.045472916,
-0.028920349,
0.029586717,
-0.016992372,
0.00126943,
-0.008003074,
-0.0024672255,
0.009589029,
0.018644962,
0.018724926,
-0.012087907,
-0.008422885,
0.027401032,
-0.019591205,
-0.00079214433,
0.017112317,
-0.02157698,
0.0055941553,
0.0054775407,
0.0026304857,
-0.023775993,
-0.01760543,
0.03222553,
0.005617478,
-0.003403472,
-0.0021007236,
-0.0054642134,
-0.01769872,
-0.00864945,
-0.01553969,
-0.0027737548,
0.017032353,
-0.012700965,
0.010975073,
0.01845838,
0.009728965,
0.008349584,
-0.0066270246,
0.031799056,
0.011488176,
0.004964438,
0.0072234236,
0.022963025,
0.019737804,
-0.0064237826,
-0.0019574545,
0.019684495,
0.021337086,
-0.016166076,
0.015832892,
0.023322862,
0.016592551,
-0.023003006,
-0.0070435046,
0.0058507067,
-0.015846219,
0.012587682,
0.015726272,
0.03625039,
0.013100785,
0.006093931,
0.00072675705,
-0.019751133,
-0.014087009,
0.014113664,
-0.013087458,
0.011668094,
-0.017085662,
-0.005880693,
0.015979493,
-0.011541485,
-0.027480995,
-0.009615683,
-0.022203365,
-0.0061205854,
0.029426789,
-0.0029020305,
-0.007549944,
0.03555737,
-0.0010353685,
-0.01463343,
0.0066136974,
0.025028763,
0.01294752,
-0.009255844,
-0.026268207,
-0.008382903,
0.021390397,
0.00598398,
0.028227327,
0.008256293,
0.0033584922,
-0.003894918,
-0.012627664,
0.017911958,
-0.024668925,
0.024908816,
-0.0044579986,
-0.0037616445,
-0.01829845,
0.014660085,
0.0017742035,
-0.025228674,
-0.040355217,
0.02937348,
0.0049511106,
0.0046878955,
-0.028707111,
0.0017908626,
-0.0025188692,
0.0050277426,
-0.00027695898,
-0.007030177,
-0.02634817,
-0.0014643426,
-0.020150954,
-0.028227327,
0.014993269,
0.016619205,
0.0109350905,
-0.010308705,
-0.0150865605,
-0.021403724,
-0.0158862,
0.062585235,
0.013660533,
0.0010495288,
0.039155755,
-0.012087907,
-0.02453565,
0.0022073423,
-0.042780794,
0.03851604,
0.013094122,
-0.0066403523,
-0.005847375,
0.013927081,
0.025468566,
0.006803612,
0.015366434,
-0.012974175,
-0.026441462,
-0.028920349,
0.0013085791,
0.012514382,
-0.034517836,
0.025415257,
0.04451335,
-0.009455754,
0.015939511,
0.03822284,
0.016632533,
0.0109350905,
-0.014526811,
-0.018125195,
0.018285124,
0.02614826,
0.007876464,
0.00145518,
0.010375342,
0.012561027,
-0.00910258,
0.020430828,
-0.0025955015,
0.014500157,
0.004731209,
0.027347721,
-0.008696096,
0.016979044,
-0.034064706,
-0.0016775802,
-0.016232712,
-0.0014626767,
-0.014713394,
0.03449118,
-0.023616064,
-0.03619708,
-0.042380974,
0.001905811,
0.015433071,
-0.011661431,
-0.009742293,
0.0034317926,
0.008276285,
-0.0075099617,
-0.018085213,
0.001560133,
0.018031904,
-0.023576083,
0.0074899704,
-0.02685461,
0.011008391,
-0.026774647,
-0.008742741,
0.013767152,
-0.006870249,
-0.008103029,
-0.009149225,
0.012254498,
-0.009022616,
0.017592102,
-0.010955081,
0.033664886,
0.005904016,
-0.0051543526,
0.010142113,
-0.001394374,
-0.025468566,
0.0021040554,
0.008509513,
-0.008249629,
-0.010668543,
-0.029586717,
0.015632981,
-0.002625488,
0.0018391743,
-0.0069168946,
0.026241552,
0.003053629,
-0.0005518356,
0.014153645,
0.013767152,
-0.021003904,
-0.023349518,
0.0012261162,
0.0106285615,
-0.0112416195,
-0.017845321,
-0.0007263406,
-0.02674799,
0.005124366,
-0.0011095019,
0.01689908,
-0.013400651,
0.024029212,
-0.020577429,
0.012574354,
-0.01749881,
0.021510342,
0.016099438,
-0.0049311193,
-0.011668094,
0.017072335,
0.0000828274,
-0.015139869,
-0.005001088,
0.02656141,
0.0021690263,
-0.0015934512,
-0.011748059,
0.012847565,
-0.010848463,
-0.01463343,
0.0026221562,
0.0010395333,
0.028627148,
0.0022389947,
-0.023709355,
-0.015033251,
-0.0016084445,
0.0032685325,
0.01740552,
0.0016134423,
-0.0036017164,
0.013240722,
-0.0040215277,
0.016685842,
-0.02438905,
0.012860892,
-0.030866142,
-0.023602737,
-0.010521943,
0.003834945,
0.017432174,
0.006607034,
-0.0033335034,
-0.031745747,
0.00022552375,
0.0031036066,
-0.052349832,
-0.009162553,
-0.006387132,
0.028067399,
0.027747542,
0.019337984,
-0.002523867,
0.021350415,
0.022349967,
-0.0019407953,
-0.0056041507,
0.0040048687,
0.009375791,
0.0031169339,
0.0060972627,
0.014953286,
-0.0039482275,
-0.010042158,
0.005370922,
0.0017625421,
0.002087396,
0.01372717,
-0.018445052,
-0.007903119,
-0.030359702,
-0.003894918,
0.015153197,
0.0070634955,
-0.000902095,
-0.028493874,
0.011421539,
0.0057374244,
0.0011161655,
0.011654767,
-0.015019923,
0.014300247,
-0.006863585,
-0.002768757,
0.0063038366,
0.005890689,
0.010908436,
-0.024548978,
-0.019231366,
-0.02801409,
-0.011188311,
0.003425129,
0.013713843,
0.036756832,
-0.010761835,
0.014620103,
0.0041981153,
-0.043713707,
-0.0075965896,
0.00052143255,
-0.010342023,
-0.00021552824,
-0.01280092,
-0.022043437,
-0.014700067,
-0.039502267,
0.028547183,
-0.0001087012,
0.017978596,
-0.006123917,
-0.01624604,
0.0028420573,
-0.011161655,
0.010282051,
-0.026081624,
0.010995064,
0.016659187,
-0.016912406,
-0.010568588,
-0.014513484,
0.007356697,
-0.0026971225,
0.018285124,
0.017965268,
-0.019857751,
-0.026881265,
0.034970965,
0.007196769,
-0.02348279,
-0.03419798,
0.019804442,
-0.0057374244,
0.016512586,
-0.008756069,
-0.01448683,
-0.0061439085,
0.010468633,
-0.009529055,
0.007769845,
-0.0031319272,
-0.020497464,
-0.012934193,
0.0024622278,
-0.021536997,
0.008842696,
-0.002807073,
-0.04763195,
0.0019124747,
-0.009029279,
-0.03454449,
0.020937266,
0.017178955,
0.02418914,
0.00676363,
0.017578775,
0.014460174,
0.012481064,
0.0011927978,
-0.017258918,
-0.0047045546,
0.032332152,
0.011308257,
-0.007363361,
0.03283859,
0.012454408,
-0.010368678,
-0.008256293,
-0.009435764,
0.013913753,
-0.018351762,
0.013767152,
0.024229122,
0.008989298,
-0.0032352142,
-0.0048911376,
-0.013420641,
-0.0019091428,
-0.01749881,
-0.0029486762,
0.030413013,
-0.022936368,
-0.010575253,
0.008016401,
0.012494391,
0.00031340096,
-0.01724559,
0.011088355,
0.0069768676,
0.026708009,
0.008542831,
0.0034101356,
0.020390846,
0.014566793,
-0.022136727,
0.008509513,
-0.019471258,
-0.013294032,
0.04008867,
-0.020230917,
-0.030306393,
0.011308257,
0.00812302,
-0.002235663,
-0.001065355,
0.00397155,
0.0048478236,
0.0044413395,
0.027081175,
0.009562373,
-0.022603186,
0.034464527,
-0.011708077,
-0.009209199,
0.013873771,
-0.01287422,
-0.003974882,
0.0036750168,
0.017112317,
-0.011108346,
-0.02192349,
-0.015246488,
-0.013927081,
0.024668925,
-0.01372717,
0.0009454089,
0.0015318122,
-0.012087907,
-0.011421539,
0.018751582,
0.016525913,
0.00083754066,
0.0069168946,
-0.024868835,
0.025375275,
0.041181512,
-0.010881782,
0.01655257,
-0.01111501,
-0.018924836,
-0.03667687,
0.021603635,
-0.009342472,
0.043020684,
0.008056383,
-0.020044334,
-0.019524567,
0.0045579537,
-0.047925152,
-0.01483334,
-0.00040044522,
0.0343046,
0.015366434,
0.028174018,
0.026108278,
0.020484136,
0.004421348,
0.033185102,
-0.013807135,
-0.019098092,
0.0453663,
-0.017885303,
0.020750685,
0.018724926,
-0.04525968,
-0.018285124,
0.012974175,
0.005980648,
0.02830729,
0.017418846,
0.012827574,
-0.0054242313,
0.020684047,
0.0125477,
-0.003585057,
0.011701413,
0.021363743,
-0.038276147,
0.011075028,
0.020070989,
0.00015971996,
0.01058858,
0.010668543,
-0.0061738947,
0.015446398,
-0.0074499887,
-0.006443774,
0.010615234,
0.017871976,
-0.017845321,
-0.011321584,
-0.006617029,
-0.0024738894,
0.026108278,
0.017138973,
-0.0025955015,
-0.001230281,
-0.004717882,
0.0076032532,
0.0009678988,
-0.0066536795,
0.0011036712,
0.013540587,
0.0011528158,
-0.024029212,
-0.017871976,
-0.012254498,
0.013234058,
-0.009589029,
0.010941754,
0.0090625975,
0.021030558,
-0.017005699,
0.018178506,
0.00884936,
-0.014246937,
-0.027347721,
-0.021217141,
-0.0046245903,
-0.03137258,
-0.02272313,
-0.022150056,
-0.027934125,
-0.034171324,
0.0027954117,
-0.047152165,
0.0040281913,
0.0028104049,
0.19138074,
-0.021856854,
-0.0012436083,
0.004904465,
-0.002217338,
-0.020604083,
0.015326452,
0.0014934961,
-0.004974433,
0.013533924,
-0.027067848,
-0.002725443,
-0.01936464,
-0.0045213033,
0.016152749,
-0.019417949,
-0.040355217,
-0.007983083,
-0.011374894,
0.016792461,
-0.018724926,
0.031212654,
-0.013100785,
-0.018391743,
0.034331255,
-0.008709423,
0.009142562,
0.022270001,
0.009589029,
-0.0045213033,
0.0005297622,
-0.005194335,
-0.006340487,
-0.008389567,
0.009835584,
-0.021283777,
-0.022843078,
-0.02674799,
0.017338883,
0.00094624184,
-0.0064637647,
0.0070834863,
0.0049144602,
-0.018525016,
0.02937348,
0.02971999,
0.0027937458,
-0.018511688,
-0.012827574,
-0.033078484,
-0.05933336,
-0.00250221,
0.008769397,
0.030093156,
-0.008669442,
0.014753376,
0.014859995,
0.010122122,
0.024069194,
0.006560388,
0.002582174,
0.009688984,
-0.029879918,
0.027401032,
-0.008862687,
0.032865245,
-0.015806237,
-0.006227204,
0.02152367,
-0.007649899,
0.0036650212,
-0.010741844,
0.0109350905,
0.0009612351,
-0.009015952,
-0.016592551,
0.026268207,
0.025002109,
-0.007170114,
0.014713394,
-0.012454408,
0.0031652455,
-0.018071886,
0.013427305,
-0.012647655,
-0.020963922,
0.03302517,
-0.003033638,
0.002750432,
0.03363823,
0.014726722,
0.00092291896,
-0.029533407,
-0.024882162,
-0.00015617989,
0.0065537244,
0.016979044,
0.016872425,
-0.040728383,
-0.010775163,
-0.012987503,
0.07084819,
-0.008662777,
-0.0007213428,
-0.009442427,
-0.013753825,
0.0036816804,
0.033824813,
0.011501503,
-0.008596141,
0.024922144,
-0.0071234684,
0.006240532,
-0.0058673657,
0.028547183,
0.04464662,
-0.006417119,
-0.025775095,
-0.013400651,
-0.009275836,
0.014473502,
-0.01840507,
-0.007116805,
0.017232263,
0.0016759143,
0.0042114425,
-0.0072900606,
-0.01876491,
-0.0141003365,
-0.027027866,
-0.000108388835,
-0.013613888,
0.0004772857,
-0.0043113977,
0.0033651558,
-0.02504209,
0.004368039,
-0.02745434,
-0.017658738,
0.017658738,
0.00870276,
0.006477092,
-0.010088804,
-0.006107258,
0.020044334,
-0.029986538,
0.020430828,
-0.003156916,
-0.00042897408,
0.0026571404,
-0.01925802,
-0.008769397,
0.011101683,
-0.03323841,
0.021417052,
-0.0067436392,
-0.022056764,
-0.01916473,
0.024962127,
0.0131807495,
-0.032545388,
0.019178057,
-0.0001436855,
-0.015313125,
-0.00266547,
0.0038882543,
-0.16835108,
0.016299348,
0.0082962755,
0.004977765,
0.029879918,
-0.009295827,
0.0019224702,
-0.006850258,
-0.003831613,
-0.007709872,
0.019884406,
-0.0046878955,
-0.015233161,
-0.024202468,
-0.00064637646,
0.0035017612,
-0.02830729,
0.021590307,
0.019951044,
0.0064937514,
0.034411218,
0.00536759,
0.019537894,
-0.023416154,
0.011474849,
-0.009968857,
-0.0050543975,
-0.018844873,
-0.01307413,
-0.023349518,
-0.007789836,
0.008642786,
0.0041981153,
0.028040744,
-0.006803612,
0.008362912,
0.009835584,
-0.008782724,
-0.004411353,
0.016179403,
-0.0013985388,
0.010488625,
-0.010928427,
0.014726722,
-0.0031919002,
0.02011097,
-0.003668353,
-0.016072784,
-0.0001897065,
0.0131474305,
0.018751582,
0.01579291,
0.0006534566,
0.0123811085,
0.0035983846,
0.008889343,
0.013187413,
-0.01865829,
0.0054908684,
0.01775203,
-0.01372717,
-0.007010186,
-0.0057940655,
-0.020057661,
-0.005697442,
-0.025548529,
-0.0009695647,
-0.007849809,
-0.01991106,
-0.010461969,
-0.03539744,
-0.0054808725,
0.029853264,
0.02549522,
0.037982948,
0.006863585,
-0.009509064,
0.009502401,
0.014753376,
-0.022549877,
-0.008582814,
0.015419744,
-0.0062072133,
-0.018285124,
-0.018231815,
0.008769397,
0.017831994,
-0.01260101,
0.012247834,
-0.014966614,
-0.0020590755,
-0.038436078,
0.021230469,
0.011408212,
-0.0017875308,
0.021630289,
0.025535202,
-0.008216311,
0.023056315,
0.014073681,
0.017871976,
-0.005557505,
-0.00087044254,
0.0021207146,
0.015726272,
-0.013234058,
0.02081732,
-0.00026279868,
0.017951941,
-0.007316715,
-0.0075432803,
0.008622795,
0.011088355,
0.03409136,
0.013900426,
0.017005699,
-0.0065837107,
-0.012394436,
-0.0142869195,
-0.029186897,
0.058267172,
-0.011468184,
0.00087960507,
0.01300083,
0.0065503926,
0.011828023,
-0.12964846,
-0.012554363,
0.007030177,
-0.000982892,
-0.004654577,
0.0019541227,
0.0044746576,
0.023642719,
-0.014606776,
0.04102158,
-0.052376486,
-0.016632533,
-0.0006163899,
0.0055208546,
0.030572942,
-0.0017692057,
0.00088710175,
-0.023322862,
0.0065837107,
0.031345926,
-0.009562373,
-0.011268274,
-0.001965784,
-0.023376172,
-0.0032502075,
-0.013513933,
-0.02926686,
0.019337984,
0.002172358,
0.0043980256,
0.004901133,
-0.015139869,
-0.007010186,
-0.042967375,
-0.010222077,
0.0069368854,
-0.040195286,
-0.015379761,
0.0026737996,
-0.012361117,
-0.0014218617,
0.0017808671,
0.020710701,
-0.0026904587,
0.0071634506,
-0.017525464,
-0.045286335,
0.012427754,
0.008496186,
0.005617478,
-0.036090463,
-0.0155130355,
-0.01372717,
-0.0016226049,
0.037503164,
-0.008496186,
-0.008242966,
0.011754722,
-0.0059006843,
-0.009055934,
0.002523867,
-0.0045479583,
0.007096814,
0.00082296383,
-0.0123811085,
-0.01604613,
-0.028040744,
-0.004527967,
0.014326901,
-0.002523867,
-0.00455129,
-0.00021906832,
-0.01608611,
-0.01604613,
-0.017565448,
-0.012674309,
-0.010108795,
-0.016579224,
0.0045879404,
-0.0011219963,
-0.004731209,
-0.021843527,
0.018644962,
-0.032465424,
0.018138524,
0.016912406,
-0.0041914517,
-0.0011994615,
0.018871527,
-0.010108795,
-0.0048911376,
0.024548978,
-0.018111868,
0.006790285,
0.012181198,
-0.011934642,
-0.0062338677,
-0.018071886,
0.0011036712,
0.013593897,
-0.012101234,
0.018165179,
-0.04531299,
0.011648104,
-0.0073700245,
-0.012294481,
0.013007494,
-0.011214965,
0.011594795,
-0.009422436,
0.033851467,
-0.0070435046,
-0.03851604,
0.029693335,
-0.032145567,
0.0029803286,
-0.0055441777,
-0.01053527,
0.008009737,
-0.00020136793,
0.01078849,
0.036117118,
-0.0068435944,
0.0017192281,
0.026934573,
0.014446847,
0.012427754,
0.0019341316,
-0.015033251,
0.015379761,
0.015486381,
-0.0012227844,
0.013360668,
-0.0040281913,
-0.015486381,
0.0020041002,
-0.0010886779,
-0.0071834414,
-0.0034384562,
0.008316266,
0.0016425959,
0.023949249,
-0.03153251,
-0.043767016,
0.0051976666,
-0.004058178,
-0.019951044,
-0.0037283262,
0.005740756,
0.032731973,
-0.016579224,
-0.024029212,
0.033424992,
0.025441911,
0.00016169823,
-0.010761835,
-0.0051143705,
0.0014002047,
0.01735221,
-0.028280636,
-0.0046012676,
-0.008716087,
0.03294521,
-0.011454857,
0.0009778943,
-0.021643616,
0.009815593,
-0.014553466,
-0.027880816,
0.005034406,
0.014820013,
-0.018325105,
-0.020390846,
0.011434866,
-0.028280636,
0.0023122951,
0.006063944,
-0.02047081,
0.017592102,
0.022070091,
-0.0072700693,
0.016725823,
0.045073096,
-0.0056941104,
-0.027587615,
0.008962642,
0.0012061251,
0.0004989427,
-0.0095223915,
0.039102446,
0.008063046,
0.031052725,
-0.018644962,
0.014859995,
-0.037476506,
0.031505857,
0.0033201762,
0.019924387,
-0.02081732,
-0.014300247,
-0.0020857302,
0.034517836,
0.01860498,
0.0018974814,
0.011754722,
0.014859995,
-0.017565448,
0.018165179,
-0.038436078,
-0.042167734,
-0.017512137,
0.016579224,
0.0012785926,
0.009395782,
0.008202984,
0.009315818,
-0.028520528,
0.014500157,
-0.00036192086,
-0.02937348,
-0.006090599,
0.02127045,
0.031265963,
0.02308297,
-0.005450886,
-0.0064271144,
0.03595719,
0.018378416,
0.0037816355,
-0.0343046,
0.00097039767,
-0.0026937907,
0.020377519,
-0.00012765103,
-0.023216244,
-0.008209648,
-0.010382006,
-0.03302517,
0.01809854,
0.0015518033,
0.005410904,
0.046592414,
0.0044146846,
0.00009438471,
0.02167027,
-0.0027187795,
0.0040948284,
-0.007876464,
0.021003904,
0.009575701,
-0.021616962,
0.015752928,
-0.0069168946,
0.011861341,
-0.0077565177,
0.0018375084,
0.025148708,
0.0020574096,
0.016725823,
-0.011068364,
0.010808481,
0.016885752,
-0.009728965,
0.013847116,
0.013740498,
-0.0007425833,
-0.011154992,
0.018165179,
-0.008442876,
0.0022240016,
-0.009475746,
0.0021273782,
0.011294929,
-0.018391743,
-0.0020957259,
0.0062371995,
-0.0011611454,
0.0041981153,
-0.014113664,
-0.003984878,
0.0036416983,
0.010855126,
0.018071886,
-0.006607034,
-0.025575185,
-0.035770606,
-0.025668476,
-0.027587615,
-0.0011178314,
-0.03278528
] |
Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 infection among human immunodeficiency virus (HIV)-infected and high-risk HIV-uninfected women. Serological tests with noninduced (latent) and induced (lytic) HHV-8 antigens were used to detect infection among 2483 participants of a multisite cohort. Reactivity to latent antigen was present in 4.1% and to induced antigens in 12.0% of women. Seven of 8 women who | [
-0.022167861,
0.0040048975,
0.002789008,
-0.030675812,
0.0017795903,
-0.0202539,
-0.0023432912,
-0.006013901,
-0.014105629,
-0.01119536,
0.0009053625,
0.017500944,
-0.013922099,
0.008521059,
-0.017645147,
0.015796732,
0.032196492,
0.013056884,
0.015495217,
-0.024855273,
-0.03306171,
0.0049749874,
-0.0007226513,
-0.010972502,
-0.021958113,
0.02102735,
0.021538615,
-0.03536895,
-0.00017656617,
-0.0014551346,
-0.0020221127,
-0.010448129,
-0.0073871026,
0.00065669505,
-0.016373541,
-0.010290817,
0.029679503,
-0.0037328792,
0.024632415,
0.003601786,
0.010657878,
0.012342426,
-0.019585326,
0.003405146,
0.015809841,
0.0061875996,
0.0032330863,
-0.012086794,
-0.004483388,
0.030203875,
0.012453855,
0.00030130954,
0.003028253,
0.03922309,
-0.010107286,
-0.0033002715,
0.010317036,
0.009360055,
0.004257252,
-0.030413624,
-0.00133797,
-0.0039229644,
-0.035447605,
0.014813533,
0.002480939,
0.0037754844,
-0.01322075,
0.013056884,
0.005705832,
0.013620584,
0.022508705,
0.018064644,
-0.02781798,
-0.010113841,
0.029312441,
-0.019663982,
-0.0029856479,
-0.0016239171,
0.010782417,
-0.0074788677,
0.025615614,
-0.015521436,
-0.0030249758,
0.010454684,
0.00041478712,
0.010670987,
0.003170817,
0.022666017,
0.011110149,
-0.012886463,
-0.0011380529,
0.0064661726,
0.008062232,
0.01987373,
-0.010238379,
0.03397936,
0.0038443084,
0.038462747,
-0.014931517,
-0.0021843405,
-0.032694645,
-0.00839652,
-0.008252318,
-0.02375409,
0.0067119724,
-0.0022433326,
0.0024104763,
-0.0021958114,
-0.0019123222,
0.00037873647,
-0.03133128,
0.026533267,
-0.003998343,
-0.043208323,
0.013292852,
-0.0012363729,
0.0037590978,
0.004899609,
-0.028211258,
-0.005758269,
0.0007705823,
0.01946734,
-0.0061187753,
-0.026952764,
0.03662744,
0.020542307,
-0.015731186,
-0.011103595,
-0.009491148,
-0.009799218,
0.0069938228,
-0.003929519,
0.015088828,
-0.012781588,
-0.012991337,
0.023832746,
-0.029705722,
-0.013450163,
-0.02548452,
-0.022102315,
0.01369924,
0.04116327,
-0.00081441656,
0.0012380115,
-0.0027005202,
0.0035985087,
0.024947038,
0.0019614822,
-0.014656221,
-0.01409252,
0.0071707987,
-0.0175796,
0.01794666,
-0.016779931,
0.0058303704,
0.0018746329,
0.00564684,
0.019729529,
-0.029627066,
-0.016648838,
-0.022062987,
-0.00214829,
0.026507048,
0.012486628,
-0.019388685,
0.022836437,
0.026349735,
-0.0094518205,
0.015521436,
-0.017671365,
-0.02431779,
0.024986366,
-0.026467718,
0.012381754,
0.022128534,
0.016727494,
6.417038e-7,
0.0030003958,
-0.006934831,
-0.029286223,
-0.02527477,
0.030597156,
0.03258977,
-0.0005505915,
-0.031226402,
-0.010008967,
0.019860622,
-0.022495596,
0.011116704,
-0.015940934,
-0.012329317,
0.025405863,
0.020214573,
-0.010926619,
-0.6586123,
-0.026874108,
0.004614481,
-0.0025137123,
0.00009514499,
0.016439088,
0.008507949,
0.002202366,
-0.02239072,
0.024593087,
-0.0041130492,
0.020122807,
-0.006623484,
-0.0028742186,
-0.0013600921,
-0.018589018,
-0.013712349,
0.005417427,
0.006220373,
0.000047572496,
-0.0077869366,
0.012355535,
0.008652152,
0.021840129,
0.029495973,
0.003772207,
0.038515184,
-0.013961427,
0.008947112,
0.020017933,
0.0006161381,
0.01949356,
-0.0110511575,
-0.020017933,
0.052384846,
-0.021276427,
-0.00714458,
0.03070203,
0.033350114,
0.055373773,
-0.037781063,
-0.017133882,
-0.0011888515,
-0.0048832223,
-0.020712728,
0.03397936,
-0.022731563,
0.015115047,
0.03224893,
0.0070593692,
0.009327282,
-0.0015878665,
-0.01466933,
-0.012761924,
0.0058893627,
-0.01662262,
0.0039557377,
-0.02182702,
0.0014715213,
0.01081519,
0.00005643153,
0.0061941543,
0.01679304,
-0.00907165,
-0.022272736,
0.004565321,
-0.015547655,
0.010480902,
0.004290025,
-0.0009872958,
0.023124842,
0.033743393,
0.008619378,
0.011995029,
0.017632037,
0.009045431,
-0.003532962,
-0.014944626,
-0.017317412,
-0.0063678524,
0.0077934912,
-0.019768856,
-0.019860622,
0.019808184,
-0.0016124465,
-0.029076474,
-0.029810596,
0.009936865,
-0.011398555,
-0.010061404,
0.028289914,
0.016098246,
-0.0033690955,
-0.027975291,
-0.0069086123,
0.031436153,
-0.012539065,
0.010651323,
-0.0063383565,
-0.003337961,
-0.0008226099,
-0.024029385,
0.034792136,
0.005754992,
0.022731563,
0.010153169,
-0.019270701,
-0.0026513601,
0.04305101,
-0.017854895,
-0.01487908,
-0.0050798617,
0.017999098,
-0.0055026375,
0.0087635815,
-0.024278462,
0.011732842,
0.006675922,
0.0008816018,
-0.030623375,
0.019742638,
0.008652152,
-0.00046620023,
-0.01794666,
-0.002744764,
0.016268667,
-0.006738191,
-0.014079411,
-0.0008226099,
-0.012696377,
0.008737362,
-0.016688166,
0.018248174,
-0.0073215556,
0.014682439,
-0.004660364,
0.034451295,
0.0068823937,
-0.009242071,
-0.017146992,
-0.016491525,
0.0061646583,
-0.0019762302,
0.011700069,
0.01872011,
-0.012375199,
-0.0051814592,
0.00867837,
-0.0033461542,
-0.007419876,
0.012847135,
-0.028421007,
-0.0026824947,
0.025825363,
0.010185942,
-0.0022515259,
0.0032461956,
-0.020031042,
0.039878555,
0.007937694,
-0.01130679,
0.03665366,
0.0066398713,
0.00819988,
0.01970331,
-0.00041007594,
0.013437054,
0.009877874,
0.016085137,
-0.038856026,
-0.019139608,
-0.022574252,
-0.014551346,
0.017514054,
0.0097861085,
0.010002412,
-0.0028414454,
-0.016779931,
-0.014787314,
0.0016140852,
0.014774205,
-0.024212915,
-0.011949146,
0.0044997744,
0.027765542,
0.01487908,
0.014905298,
-0.00589264,
0.022285845,
0.013404281,
0.0005915581,
-0.0033166583,
0.0010323591,
0.01322075,
-0.002315434,
0.0014608699,
0.021014242,
0.016360432,
0.017317412,
0.022403829,
0.012303098,
-0.007315001,
-0.00091765245,
-0.009491148,
0.024265353,
-0.03088556,
-0.0016345684,
-0.027319824,
0.035447605,
0.0018418595,
0.022954421,
-0.0031675396,
-0.008842237,
-0.0028103106,
-0.033507425,
-0.0020663568,
-0.014983954,
0.01566564,
-0.015560764,
-0.016871696,
-0.0150495,
0.0076951715,
-0.0009299425,
0.00060876406,
-0.0017877837,
0.029233785,
0.015967153,
-0.010539894,
0.011555866,
-0.0011290403,
-0.019074062,
-0.005797597,
0.011319899,
0.018221956,
0.00068742,
0.0015845891,
0.011660741,
-0.015167484,
-0.0052470057,
0.00627281,
-0.016675057,
0.009556695,
-0.0030544717,
0.008534168,
0.017291194,
0.0070397053,
0.022482485,
0.0012306375,
-0.01178528,
0.021197772,
-0.0054633096,
0.0009487871,
-0.000360916,
0.005777933,
-0.00955014,
-0.017120773,
-0.0075902967,
0.014682439,
0.02374098,
0.029181348,
0.01911339,
-0.00051167316,
0.0059581865,
-0.016766822,
-0.0069282763,
-0.0004993832,
-0.01874633,
-0.0069938228,
-0.018484142,
0.008160552,
-0.03148859,
-0.021381302,
0.0052732243,
-0.009287954,
0.009727116,
0.015613201,
-0.004040948,
-0.0008045846,
0.015600092,
0.0041130492,
-0.028735632,
-0.008239208,
-0.0017009344,
0.01698968,
0.0056894454,
-0.007164244,
0.017199429,
0.0050864164,
0.006869284,
0.0013084741,
0.033087928,
0.010166278,
0.0026103936,
0.0072494545,
0.00060876406,
-0.004650532,
0.026402172,
-0.012054021,
0.003156069,
0.011903264,
-0.013017556,
-0.005063475,
-0.02779176,
-0.01929692,
0.012348981,
0.0011544395,
0.003542794,
-0.0023465685,
-0.008271982,
0.00028717605,
0.015927825,
0.0048963316,
-0.010107286,
0.0014895466,
-0.0019090449,
0.029836815,
-0.017736912,
0.016347323,
0.023872074,
-0.0042408654,
-0.00801635,
-0.03893468,
-0.043418072,
-0.03591954,
0.026677469,
0.010631659,
-0.0014002393,
0.030466061,
0.03306171,
0.006810292,
-0.006974159,
-0.025314098,
-0.0063154153,
-0.010067958,
-0.00579432,
0.0012199862,
0.0019237929,
0.012080239,
0.03471348,
0.0072166813,
0.0077738273,
-0.005509192,
0.009301064,
0.02298064,
0.013214195,
-0.021512397,
0.005637008,
0.03518542,
0.016570183,
-0.012761924,
0.01951978,
0.019218264,
-0.0093403915,
-0.02607444,
-0.0077934912,
0.017199429,
-0.008108115,
0.009687788,
-0.0038279218,
-0.02663814,
-0.002808672,
0.005456755,
0.02933866,
0.0111625865,
0.04690515,
0.026375953,
0.0049356595,
0.024265353,
0.012525956,
0.012237551,
0.016452197,
0.018628346,
0.0039655697,
-0.007334665,
0.029260004,
-0.00036624164,
-0.011962255,
-0.022915093,
-0.0013756594,
0.010638214,
0.009445266,
-0.014354707,
-0.017514054,
0.01246041,
-0.0077148355,
-0.006312138,
0.00020923706,
-0.016766822,
-0.037414003,
0.008376856,
-0.010880737,
-0.0016271945,
-0.027582012,
-0.017723802,
0.017671365,
-0.020109698,
-0.016229339,
0.013187977,
-0.0077476087,
0.03201296,
-0.0059155812,
-0.009799218,
0.0102514895,
0.025248552,
-0.023727871,
-0.0073281103,
-0.008586605,
-0.014380925,
0.024553759,
0.014682439,
0.0036443912,
-0.0040769987,
-0.0076427343,
0.0044899425,
0.014826642,
-0.016242448,
-0.004929105,
0.008389966,
0.006967604,
0.011398555,
0.003900023,
0.027844198,
-0.03822678,
-0.011516538,
-0.0029168238,
-0.041005958,
0.009163415,
-0.031541027,
-0.01756649,
-0.0010020437,
-0.030072782,
-0.0025776203,
-0.015101938,
-0.023819637,
0.008081896,
-0.02642839,
-0.004853726,
0.0053682667,
0.002525183,
0.015534545,
-0.0023482072,
-0.0043555717,
0.03258977,
-0.00202539,
-0.0052830563,
0.008481731,
0.031960525,
-0.005384654,
-0.006262978,
0.029522192,
-0.0006419471,
-0.016085137,
-0.025576286,
-0.02975816,
0.0061023887,
0.03665366,
0.022403829,
-0.004617758,
-0.031357497,
-0.0008881565,
-0.0030561103,
0.0061351624,
0.0059057493,
-0.024947038,
-0.011215024,
-0.009078205,
-0.014970845,
-0.006797183,
0.0043621263,
-0.036365256,
-0.008081896,
0.04187117,
-0.017750021,
-0.01487908,
0.007006932,
0.025327208,
-0.00041069044,
0.009884428,
-0.025445191,
-0.0066038202,
0.0051191896,
0.00082752586,
0.0264415,
-0.0025972843,
0.019559108,
-0.010218715,
-0.004909441,
0.033664737,
0.004643977,
0.012899572,
-0.0042834706,
0.012434191,
-0.011201914,
0.012093348,
0.00139942,
0.0017992543,
-0.0028201428,
0.01430227,
0.01369924,
0.00801635,
-0.018890532,
-0.012316207,
-0.026402172,
-0.03167212,
0.005961464,
0.0034117007,
-0.019650873,
0.0101400595,
-0.04635456,
0.008180216,
0.011686959,
-0.024658633,
0.010297372,
0.00039020713,
0.0206734,
-0.0023891737,
-0.011418219,
-0.024094932,
-0.008796355,
0.0030397237,
0.0018713556,
-0.0031872038,
0.005083139,
0.026900327,
-0.003591954,
0.013011001,
0.030597156,
-0.016058918,
-0.0033264903,
0.009831991,
-0.014800424,
-0.02105357,
-0.01600648,
-0.024055604,
-0.0031691783,
-0.008285091,
-0.01717321,
-0.003190481,
-0.021145334,
-0.000119929806,
0.0052044005,
0.008304755,
-0.015324797,
-0.011903264,
0.013791006,
0.00029885155,
0.029469753,
-0.036732316,
0.061823558,
0.021132225,
0.007950803,
-0.03665366,
-0.008750472,
0.0015149459,
-0.0027087135,
0.02355745,
0.028892944,
0.0038574177,
-0.003513298,
0.03188187,
0.017750021,
-0.00028779055,
-0.0397999,
0.034110453,
0.026467718,
-0.010743088,
-0.00964846,
-0.012820916,
-0.028132603,
0.038856026,
-0.027241169,
0.004781625,
-0.0051421314,
-0.0017205984,
-0.01215234,
0.030151438,
0.0010954477,
0.044125974,
-0.021433739,
-0.0150495,
-0.0202539,
-0.04014074,
-0.0042212014,
-0.0020090034,
-0.011300235,
0.0118836,
0.008153997,
0.0011765616,
0.0018746329,
-0.022744672,
-0.00047562254,
0.014708658,
-0.026113767,
0.036968283,
-0.007236345,
-0.008553832,
0.011411664,
0.009779554,
0.003929519,
0.0069086123,
0.006551383,
-0.024593087,
-0.006698863,
0.0010405524,
0.03321902,
0.0030184211,
0.003611618,
-0.0016632451,
-0.023242826,
0.016911024,
-0.033481207,
-0.04926483,
0.016871696,
-0.045987498,
-0.012945455,
-0.019323139,
-0.009176524,
0.008422739,
0.02860454,
-0.00070134865,
-0.016425978,
0.012657049,
-0.037728626,
0.011123259,
0.010762753,
0.015495217,
-0.014026973,
-0.0069282763,
-0.007931139,
-0.011339563,
0.014158066,
0.0030675812,
-0.014630002,
-0.020411212,
0.011529648,
0.01970331,
0.0185628,
-0.014223613,
0.026585704,
-0.022062987,
0.00831131,
-0.01272915,
0.00071855466,
0.035080545,
-0.010100732,
-0.010323591,
-0.010513675,
-0.036942065,
0.028525883,
0.0002720184,
0.02333459,
-0.01872011,
-0.037387785,
-0.029495973,
-0.006708695,
0.00405078,
0.0053158295,
0.0025563175,
-0.00015178135,
-0.011667295,
-0.01601959,
-0.012230996,
0.0073739933,
-0.011791835,
-0.011116704,
0.015324797,
-0.014197394,
0.02357056,
-0.003328129,
0.008632488,
0.0076427343,
-0.0118836,
-0.023124842,
-0.000359687,
-0.011215024,
0.03182943,
0.01109704,
-0.00086111855,
-0.037414003,
-0.026362844,
-0.047377087,
-0.0015116686,
-0.013312516,
0.0013199447,
0.010756198,
0.031908087,
-0.010847963,
-0.0058336477,
-0.0044276733,
0.05264703,
-0.03725669,
-0.01971642,
0.015377234,
-0.008770136,
0.014931517,
0.01620312,
-0.008462067,
0.0014321933,
0.023203498,
0.0040638894,
-0.012775034,
0.027949072,
-0.018287502,
-0.00016827043,
-0.021617271,
0.011700069,
0.000686191,
-0.002315434,
0.003601786,
-0.00946493,
-0.014446472,
0.013856553,
0.004909441,
-0.0051257447,
-0.018431704,
0.008953666,
0.0040933853,
-0.0070003774,
-0.01639976,
-0.014498909,
0.009668124,
-0.032117836,
0.0118311625,
0.014184285,
-0.002485855,
0.010638214,
0.002094214,
0.0024301403,
0.009884428,
0.008547277,
-0.007223236,
0.007780382,
0.01872011,
-0.012801252,
-0.023819637,
0.0014084327,
-0.0020729115,
-0.013620584,
0.0057484373,
0.0051257447,
-0.01813019,
-0.030911779,
0.035683572,
0.0020565246,
-0.0015600092,
0.0124473,
0.009458375,
-0.009189634,
-0.023019968,
-0.017251866,
-0.0070724785,
0.005289611,
-0.015613201,
-0.00907165,
0.009720561,
0.0036869966,
-0.013791006,
-0.0013928653,
-0.026585704,
0.0032314477,
0.18646698,
0.012394863,
0.0052732243,
0.012342426,
-0.021840129,
-0.0006968423,
0.019965496,
0.007891811,
0.011188805,
0.01641287,
0.0320654,
-0.008239208,
0.008547277,
0.009963084,
0.003023337,
-0.0305185,
-0.009681233,
-0.02296753,
0.009956529,
-0.014892189,
0.022888875,
-0.009104423,
0.0040671667,
-0.014551346,
0.021289537,
-0.008809464,
-0.037781063,
0.011975365,
0.013155203,
-0.011280571,
-0.0029184625,
-0.005620621,
0.0071970173,
0.0061744903,
-0.007065924,
-0.008488285,
-0.0025038803,
-0.0038049803,
0.0052371738,
0.030361187,
-0.0029430427,
0.0077934912,
-0.013279743,
-0.008979885,
-0.009497703,
0.028919162,
0.010271153,
-0.027083857,
-0.012899572,
-0.011562421,
-0.01831372,
0.0054698642,
-0.00482423,
0.0015903244,
-0.018248174,
0.0083178645,
0.04381135,
0.0029790932,
-0.038724933,
0.024829054,
-0.0015747572,
-0.0044080094,
-0.022312064,
0.03279952,
-0.009641905,
0.0397999,
-0.0012306375,
-0.026205532,
-0.026087549,
-0.007164244,
0.015403452,
-0.009681233,
-0.029967908,
0.011516538,
-0.009831991,
-0.013489491,
0.017343631,
0.02084382,
0.021761473,
0.0010479264,
0.0052044005,
-0.009930311,
-0.024829054,
0.021984331,
-0.041425455,
-0.025930237,
0.022495596,
0.014446472,
-0.014734876,
0.029181348,
-0.0034215327,
-0.011726287,
-0.014813533,
0.007583742,
0.018182628,
0.017029008,
-0.009779554,
-0.010179387,
0.01601959,
-0.006033565,
-0.017343631,
0.067696534,
0.01797288,
-0.0070200413,
-0.008180216,
0.0065939883,
-0.016648838,
-0.0019008515,
0.021158444,
-0.036181726,
0.019860622,
-0.023806527,
0.0072297906,
-0.009772999,
0.0048504486,
0.017238757,
0.007380548,
-0.0160327,
-0.01390899,
0.024475101,
-0.01718632,
-0.012971673,
0.019795075,
0.02104046,
-0.023649216,
-0.0424742,
-0.0413468,
0.018235065,
-0.007977022,
-0.013404281,
0.017736912,
-0.013843443,
-0.018208846,
0.018615237,
0.017789349,
-0.0040343935,
0.0005329758,
0.0027021589,
-0.012060575,
0.0055714613,
-0.0075968513,
-0.018851204,
0.026808562,
0.0019663982,
-0.0070528146,
-0.017527163,
0.020935586,
0.026218642,
0.0053453255,
0.0005616525,
-0.020044152,
-0.020162135,
0.00867837,
-0.0057484373,
0.020791383,
-0.02975816,
-0.029784378,
-0.0087898,
0.0062859193,
0.009235516,
-0.020607853,
0.026415281,
0.0063088606,
-0.0033002715,
-0.012925791,
-0.005427259,
-0.16517745,
0.0042638066,
-0.0034543062,
-0.016583292,
0.035054326,
0.023531232,
0.008134333,
-0.003850863,
-0.014066301,
0.01831372,
0.03012522,
-0.005673059,
-0.03591954,
-0.0023416525,
-0.005073307,
-0.008750472,
-0.00008951208,
0.025130568,
0.05157207,
-0.011241242,
0.036758535,
-0.024422664,
0.015023282,
-0.011188805,
0.010992166,
0.021512397,
-0.016465306,
0.012820916,
0.0038672497,
-0.009523922,
0.00029803222,
0.02220719,
0.032117836,
-0.008875011,
0.009569804,
-0.013201086,
0.010723424,
-0.0016165432,
0.0025563175,
0.00012443613,
0.030544719,
0.0044604465,
0.021092897,
0.0016288331,
-0.007544414,
0.000698481,
0.013804115,
-0.015704967,
0.005269947,
0.00093731645,
0.021499287,
-0.020149026,
0.049684327,
0.014315379,
0.009668124,
-0.0029266558,
-0.002426863,
0.020712728,
0.014040083,
-0.008868456,
-0.0047390196,
-0.03455617,
0.012047466,
-0.012768479,
0.014367816,
-0.048950203,
-0.014761096,
0.009412493,
-0.018811876,
0.015429671,
-0.009412493,
-0.0042736386,
-0.007164244,
-0.0305185,
0.017029008,
0.01081519,
-0.026375953,
0.018969188,
-0.007183908,
-0.020817602,
-0.022115424,
0.0033789275,
-0.029469753,
-0.0160327,
-0.017802458,
-0.0034674155,
0.010035185,
-0.0001879344,
0.026323516,
-0.012303098,
-0.0032806075,
-0.014747987,
-0.00391641,
-0.027267387,
-0.0007881979,
0.017854895,
0.0031298504,
0.0023531232,
-0.02991547,
-0.006151549,
0.01854969,
-0.011005275,
-0.025222333,
0.02355745,
0.0016657031,
-0.029233785,
-0.01948045,
-0.0040540574,
0.038069468,
0.0032330863,
-0.031357497,
0.016740603,
0.012027802,
0.025799144,
-0.019257592,
0.040979736,
-0.0012330955,
0.011909818,
0.029207567,
-0.029312441,
0.053040314,
0.0070200413,
-0.02721495,
0.0013609114,
-0.004650532,
-0.032694645,
-0.12584949,
-0.009838546,
0.0014108907,
-0.00016028194,
-0.004476833,
0.034949448,
0.0019696755,
0.013777897,
-0.0025481242,
0.006056506,
-0.016360432,
-0.015940934,
-0.017789349,
-0.004781625,
0.007275673,
-0.009274845,
0.005754992,
-0.007682062,
-0.03591954,
0.035447605,
-0.0047193556,
0.004349017,
0.0013453441,
-0.005374822,
0.0034411969,
-0.017120773,
-0.029889252,
0.020319447,
0.0060204556,
0.008566941,
0.0033002715,
-0.008252318,
0.0023940897,
-0.008704589,
-0.028630758,
-0.0024645524,
-0.023387028,
-0.00858005,
0.017461615,
-0.020031042,
0.017409177,
0.026310407,
0.027870417,
0.011005275,
0.014407144,
-0.006341634,
-0.028132603,
-0.0068889484,
0.010992166,
-0.015154375,
-0.033559863,
-0.0091371965,
-0.029469753,
-0.0022335006,
0.014171176,
-0.02279711,
0.0022908538,
0.03203918,
-0.016085137,
-0.007124916,
-0.012250661,
0.006954495,
-0.015796732,
0.021394411,
0.018248174,
0.0011167503,
-0.010788972,
-0.010782417,
0.007977022,
-0.03049228,
0.003047917,
-0.04014074,
-0.006810292,
-0.0014125294,
-0.0046898597,
0.014787314,
0.006610375,
-0.008186771,
-0.0008619379,
-0.010074513,
-0.020031042,
-0.00012843037,
0.0155869825,
0.014105629,
0.029233785,
0.012735705,
0.008304755,
-0.0160327,
0.0014543153,
0.0064432314,
0.008901229,
0.050234918,
0.010369473,
-0.02357056,
0.0031282117,
0.023478793,
-0.032878175,
-0.02604822,
0.014380925,
0.026310407,
-0.013922099,
-0.007813156,
-0.053905528,
0.016517745,
0.001707489,
-0.016779931,
-0.007223236,
0.005083139,
-0.02046365,
0.0012929068,
-0.002207282,
0.024593087,
-0.017920442,
0.019559108,
-0.02642839,
0.013974536,
-0.020778274,
0.0028217814,
0.01681926,
-0.00023105179,
0.022312064,
0.011555866,
0.015154375,
-0.010277708,
-0.0107168695,
0.034661043,
0.0017337077,
0.022115424,
-0.038515184,
0.025969565,
0.0010929896,
0.00069069734,
0.02164349,
-0.026362844,
-0.0039426284,
0.007367438,
0.012119567,
-0.0151412655,
0.027739324,
0.026087549,
0.015206812,
0.020332556,
-0.036050633,
-0.03106909,
-0.00936661,
0.0072691184,
-0.009012658,
-0.0020532473,
-0.005754992,
0.008036014,
0.0024825777,
-0.0058303704,
0.032642208,
0.009792663,
-0.022049878,
-0.018942969,
-0.015967153,
-0.006400626,
-0.016111355,
-0.0063744076,
-0.00955014,
0.0078066005,
0.012571839,
-0.00032117838,
0.015272359,
-0.0048864996,
-0.00094223244,
-0.019165827,
-0.012637385,
0.006757855,
-0.0013101128,
0.013266633,
-0.020162135,
0.011287126,
-0.021905676,
0.011811499,
-0.014367816,
0.00026525892,
0.0038246445,
0.01797288,
-0.0109397285,
0.0050274245,
-0.005397763,
-0.020712728,
0.0063744076,
0.009963084,
0.025759816,
0.01563942,
0.003683719,
0.018811876,
-0.00579432,
0.0057713785,
0.006439954,
0.015075719,
0.01948045,
0.0122768795,
-0.011221578,
0.0059286905,
0.0054239817,
-0.009700897,
0.01951978,
0.035578698,
0.021499287,
0.010854518,
0.012578393,
-0.028499665,
-0.013594366,
0.012126122,
-0.037912156,
-0.0336123,
-0.014420253,
-0.010906955,
0.0041130492,
0.0016206398,
-0.018064644,
0.0012953648,
-0.013856553,
-0.0258778,
-0.0061679357,
0.016478416,
-0.022888875,
0.031986743,
-0.009189634,
0.042212013,
0.008193325,
-0.011949146,
0.0175796,
-0.016085137,
0.032694645,
-0.02084382,
0.016871696,
-0.016098246,
-0.011201914,
-0.014459581,
-0.041215707,
-0.013115875,
-0.0016329298,
-0.0034575835,
0.005673059,
0.014997063,
0.01157553,
0.06261012,
-0.004794734,
-0.030780686,
0.007380548,
-0.02472418,
0.0041032173,
0.011260907,
0.004624313,
0.007367438,
-0.021722145,
-0.00030458687,
-0.018103972,
0.017264975,
-0.044807658,
-0.026874108,
-0.009287954,
0.00342481,
-0.01698968,
-0.0071576894,
-0.013391172,
0.0043785134,
-0.01302411,
0.013161758,
0.0025481242,
-0.007124916,
0.0037132152,
0.011444437,
-0.004942214,
-0.0048176753,
-0.028499665,
0.0029397653,
0.0036247273,
-0.023976948,
-0.019663982,
0.0031380437,
-0.018208846,
-0.023085514,
-0.015482108,
0.016255558,
-0.011215024,
-0.013856553,
-0.0015460806,
-0.008245762,
0.0061351624,
0.0056992774,
-0.032537334,
-0.028316133,
-0.00010784465,
-0.0010839769
] |
Neuronal Cdc2-like kinase (Nclk) is involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics. The active kinase consists of a catalytic subunit, Cdk5, and a 25 kDa activator protein (p25nck5a) derived from a 35 kDa neuronal-specific protein (p35nck5a). As an extension of our previous study (Qi, Z., Tang, D., Zhu, X., Fujita, D.J., Wang, J.H., 1998. Association of neurofilament proteins with neuronal Cdk5 activator. J | [
-0.013283998,
-0.011409241,
0.0031820666,
-0.0053363643,
-0.014944498,
0.010726293,
-0.025670791,
0.0003343597,
-0.021117808,
-0.0048074145,
0.021358848,
0.004449202,
0.0072312085,
0.023220215,
-0.024478981,
0.0071106884,
0.011449413,
-0.01925644,
-0.0049948907,
0.0005858618,
-0.027773198,
0.027987456,
-0.006334003,
-0.038298625,
-0.0053464076,
0.011268633,
-0.02091694,
-0.016337175,
-0.0059289215,
-0.025376186,
0.009829087,
0.004141206,
0.016671954,
0.0032473484,
0.0041479017,
-0.012755048,
0.010143779,
-0.01744864,
0.005326321,
0.017020123,
0.016497869,
0.0036758643,
-0.02044825,
-0.017917328,
-0.0060427464,
0.003451563,
0.0005461069,
-0.012534095,
-0.024626283,
0.03288861,
0.0043655075,
0.020716073,
-0.009929521,
0.0047638933,
-0.0095077,
-0.024612892,
0.010933856,
0.008804666,
0.01485076,
-0.030344294,
-0.020220602,
0.014636502,
-0.0013273954,
0.0053464076,
0.01205871,
-0.010967333,
0.0007482292,
-0.0026464215,
0.008610494,
-0.007807027,
0.034415197,
0.018211933,
-0.005925574,
-0.0016345545,
0.026179655,
-0.0050417595,
-0.04692251,
-0.0063440464,
-0.023327343,
-0.005503753,
0.0052894955,
-0.027264334,
-0.012373402,
0.02636713,
0.008931882,
-0.0021743842,
-0.006812736,
0.015614054,
-0.013123305,
-0.0015224038,
0.017796809,
0.021077635,
0.023220215,
0.0010202365,
-0.009340311,
0.0058987914,
0.0039671212,
0.0049915425,
-0.025135146,
-0.0104116015,
-0.003776298,
0.007673116,
-0.01664517,
-0.01827889,
-0.026166262,
0.0016337176,
-0.0038599924,
-0.017877154,
0.02305952,
0.022550657,
-0.008710928,
0.026152872,
-0.005242626,
-0.04311943,
0.028844489,
-0.023662122,
0.0067123026,
0.004911196,
-0.0043655075,
-0.008751102,
0.02209536,
0.03765585,
0.016698735,
-0.018479755,
0.028657012,
0.021439195,
0.012172535,
-0.00356204,
-0.024010291,
-0.010237517,
0.002360186,
0.009641612,
0.00340302,
0.017743243,
-0.01402051,
0.020943724,
0.011543152,
0.0037997323,
-0.016390739,
-0.036397085,
0.0013114936,
0.019631393,
-0.020327732,
0.015292667,
0.00668552,
0.0068361703,
0.005232583,
0.0144892,
0.015346232,
0.0071843397,
0.018519929,
0.009869261,
0.01960461,
-0.002395338,
-0.017046904,
0.033424255,
-0.006692216,
0.019698348,
-0.000981737,
-0.029246222,
-0.014167813,
-0.010498644,
0.000026298396,
-0.028576665,
0.0579568,
0.01616309,
0.01865384,
-0.0010821705,
0.014957889,
-0.025309231,
-0.0089519685,
0.023300562,
-0.03492406,
0.0109070735,
-0.005413363,
-0.008577017,
0.011261938,
0.012976002,
-0.022738134,
0.010532121,
-0.009353702,
0.023233606,
0.010404906,
-0.0029477219,
-0.001779346,
0.0032322833,
0.036986295,
-0.010090214,
-0.014649893,
0.00032075934,
0.002930983,
-0.011395849,
-0.026782254,
-0.027907109,
-0.627776,
-0.02435846,
0.0104116015,
-0.018707404,
-0.0038298625,
0.03398668,
0.009534483,
-0.0027669417,
-0.01865384,
0.010116996,
-0.0030146774,
0.01959122,
0.0070772106,
0.004680199,
-0.050939847,
-0.021599889,
-0.022644397,
-0.009842479,
0.0108802905,
-0.0069165174,
-0.0050350637,
0.005058498,
-0.021720408,
0.007940939,
0.00161112,
0.025670791,
0.010050041,
-0.032942172,
-0.0030799592,
0.019979563,
-0.025269058,
0.022778308,
-0.01015717,
0.007405293,
0.039664518,
-0.01744864,
-0.013424605,
0.019162703,
0.012353315,
0.038057584,
-0.02804102,
-0.00837615,
0.011295415,
0.007284773,
-0.01377947,
-0.006123093,
-0.0028355713,
0.00046910794,
0.002145928,
-0.0044994187,
0.013364345,
-0.024920888,
-0.01794411,
-0.0017324771,
-0.022497093,
-0.008764492,
0.010043345,
-0.02351482,
0.01145611,
0.025603835,
-0.0011692127,
-0.0019333439,
-0.004465941,
-0.017877154,
-0.0184128,
-0.00016623829,
-0.017435247,
-0.023260389,
-0.00896536,
0.006059485,
0.024050465,
0.012447053,
0.01211897,
0.0008239728,
-0.002179406,
0.02541636,
0.0060996586,
-0.0014713501,
-0.009869261,
-0.0055439267,
-0.0077735493,
-0.010840118,
-0.029621173,
0.009152835,
-0.0095077,
-0.0063741766,
-0.026420694,
0.0068328227,
0.014864151,
0.0051823664,
0.017984284,
-0.03620961,
-0.00371269,
-0.04834197,
-0.041405365,
0.034468763,
0.0063105687,
0.006002573,
0.0012612768,
-0.02256405,
-0.009574656,
0.011020898,
0.007840505,
-0.017060297,
0.001134898,
-0.0018312366,
-0.023956727,
0.015600664,
0.04097685,
-0.025992177,
-0.018426191,
-0.008844839,
-0.011027593,
-0.027023295,
-0.008469888,
-0.031094197,
0.033477817,
0.02589844,
0.0144892,
-0.01288896,
-0.008583712,
0.010244212,
0.010337951,
-0.0075258133,
0.021372238,
-0.0010311168,
-0.011275329,
-0.002669856,
0.00011528924,
-0.022055186,
-0.002530923,
0.013679037,
0.041619625,
0.0026949644,
0.027960673,
0.016591607,
0.0149980625,
0.017207598,
0.000110581415,
-0.0396913,
-0.0140339015,
-0.005831836,
0.00095160695,
-0.023648731,
0.0019433873,
-0.00867745,
-0.033209994,
0.0052861474,
0.008389541,
0.018854707,
0.007780245,
-0.0067256936,
0.0035017799,
0.00007548202,
0.01830567,
-0.017073687,
-0.031870883,
-0.021157982,
0.011128027,
-0.020528598,
-0.001243701,
0.0012478856,
-0.03489728,
-0.0020739508,
-0.025362795,
0.0019132573,
0.022483703,
0.01664517,
0.0010963986,
-0.03492406,
-0.008784579,
-0.021291893,
-0.015426579,
0.019818868,
0.03053177,
0.011255243,
0.0056075347,
-0.018560102,
0.0018630406,
-0.0017559115,
-0.002519206,
-0.03264757,
-0.018586885,
-0.01984565,
0.017435247,
0.03436163,
0.02863023,
-0.0033477817,
0.003314304,
0.034656238,
-0.022323009,
0.0099161295,
-0.015145365,
0.020006344,
0.017649505,
-0.039503824,
0.025336012,
-0.021506151,
-0.008007894,
0.02291222,
0.0025041408,
-0.025456533,
0.0026196393,
0.00202206,
0.008389541,
-0.022885436,
-0.008751102,
-0.02055538,
-0.0046701557,
0.015359623,
0.005045107,
0.01993939,
-0.0062603517,
-0.011898017,
0.004204814,
-0.006015964,
-0.014743631,
-0.005091976,
-0.0076463334,
-0.02031434,
-0.003759559,
-0.003237305,
0.005567361,
-0.011322198,
0.0016353914,
0.042262398,
-0.004024034,
0.04547627,
0.02008669,
-0.006949995,
-0.015600664,
0.013270607,
-0.0025041408,
0.0046601123,
-0.006518131,
0.01236001,
0.0173549,
-0.019149313,
0.027264334,
0.012192621,
0.0121323615,
0.022845263,
-0.021305284,
0.0003745331,
0.0020990593,
-0.011683758,
0.0044257673,
0.019684957,
0.009661699,
0.01628361,
0.001518219,
0.023447864,
-0.01827889,
0.011630194,
-0.013123305,
-0.012125665,
0.01566762,
0.0069366037,
0.04121789,
0.019510873,
0.024130812,
-0.0072512953,
0.004643373,
-0.004184727,
0.0076061604,
0.0064846533,
0.030960286,
-0.005574057,
-0.0114695,
-0.0041679884,
-0.018506538,
0.011409241,
0.003223914,
-0.024438808,
0.0068093883,
0.010739684,
0.0056376643,
0.011730627,
0.01627022,
0.02591183,
-0.0033728902,
-0.021519542,
0.01169715,
0.029540827,
-0.010110301,
-0.017903937,
-0.036450647,
0.017555768,
-0.01604257,
0.015975615,
-0.021211546,
0.022965783,
-0.017649505,
-0.0019417134,
-0.0273179,
-0.034468763,
0.023541601,
-0.011282025,
0.017877154,
-0.01592205,
-0.005932269,
0.00766642,
-0.016832646,
-0.0055640135,
0.026300173,
0.006307221,
0.011576629,
0.00047998823,
0.0048074145,
-0.016805865,
0.014100857,
-0.009668394,
0.011255243,
0.0023032739,
-0.011677063,
-0.016671954,
0.024894105,
-0.0062101353,
0.03765585,
0.009353702,
-0.01711386,
-0.009681785,
-0.0042115096,
-0.017180815,
0.01876097,
0.024291504,
0.0029895692,
0.014529373,
0.00024752662,
-0.012326533,
-0.027170597,
-0.00077961467,
0.021720408,
-0.0077333758,
-0.01581492,
-0.039503824,
-0.0023518167,
0.0007946797,
0.0069432994,
0.01710047,
-0.0026045742,
-0.006009268,
-0.00036972066,
0.020541988,
0.017207598,
0.008027981,
0.03254044,
0.04220883,
0.03460267,
0.00076454965,
-0.00006753104,
0.031308457,
0.01913592,
-0.04003947,
0.005892096,
0.025402969,
-0.0027719634,
0.0065583047,
-0.00276192,
-0.033718858,
-0.0073450333,
0.02375586,
0.0023233606,
0.029647956,
0.02342108,
-0.0044692885,
-0.0017960849,
-0.010732989,
0.0071709487,
-0.015881877,
0.024211157,
0.0007360935,
-0.00013527132,
-0.0072646863,
0.027183989,
-0.008141805,
-0.017676288,
-0.026099307,
0.012982698,
-0.003498432,
0.002807115,
-0.02388977,
0.012547486,
-0.024090638,
-0.0063105687,
-0.008637277,
-0.0016186525,
-0.022764916,
-0.0013140043,
-0.0034649542,
0.0007273056,
-0.0065783914,
-0.033772424,
-0.010337951,
0.010351341,
-0.031308457,
-0.0508595,
-0.00837615,
0.007505727,
0.018265497,
0.03157628,
-0.012493921,
0.0027719634,
0.036772035,
-0.0063239597,
-0.0010604099,
-0.02588505,
-0.041646406,
-0.031495932,
0.007257991,
0.011737323,
-0.01758255,
0.03288861,
-0.012045319,
0.005888748,
-0.013699123,
0.017555768,
0.006862953,
-0.010666033,
0.0098893475,
0.029888997,
0.021640062,
0.010371428,
0.0023551644,
-0.0055271876,
-0.025282448,
0.002132537,
-0.0028941573,
-0.014127639,
-0.016189873,
0.005938965,
0.014877542,
-0.002758572,
-0.0062201787,
0.0017592594,
-0.023608558,
0.019711738,
0.020836594,
0.004003947,
0.03567396,
0.020033127,
-0.0011733975,
0.004897805,
0.00044107024,
-0.00041993737,
0.0036323431,
0.02304613,
-0.0049513695,
-0.022349792,
0.027264334,
0.01003665,
-0.008818057,
-0.010679424,
0.010143779,
0.004787328,
0.0380308,
-0.024170985,
-0.023032738,
0.0016956514,
-0.0072981645,
-0.004643373,
0.0020036474,
-0.000341683,
-0.011536456,
-0.014783804,
0.0012662985,
0.014931107,
0.0040474683,
0.021399021,
-0.03754872,
-0.04220883,
0.007967721,
-0.012232794,
0.015895268,
-0.016551433,
0.0041311625,
-0.02256405,
-0.023554992,
-0.007030342,
-0.015747966,
0.015533707,
-0.0021894493,
0.026139481,
0.008623886,
0.050591677,
0.030879939,
0.008021285,
0.012654616,
0.009661699,
-0.0113757625,
-0.02090355,
0.02125172,
-0.028603448,
0.037146986,
0.0011181592,
-0.01003665,
0.0067256936,
-0.0012997763,
-0.0029125703,
0.016712127,
0.0059490083,
-0.018801143,
0.0065917824,
-0.029246222,
-0.011482892,
0.019778695,
-0.03540614,
-0.006180005,
-0.018332453,
-0.020501817,
0.019684957,
0.015774747,
0.002656465,
0.008269021,
0.012393489,
-0.0017308032,
0.013792861,
-0.00475385,
0.027277727,
-0.010009867,
-0.0017693026,
0.010706206,
0.0016613367,
0.015520317,
0.028576665,
0.022952393,
0.002684921,
0.027505375,
-0.026889384,
0.0077266805,
-0.02518871,
-0.007150862,
-0.03337069,
-0.054341193,
-0.030853158,
-0.019430526,
-0.006046094,
-0.03162984,
0.00068503985,
0.013444692,
-0.028442753,
0.005249322,
-0.004439159,
-0.012226099,
0.0529753,
-0.019082356,
0.018586885,
-0.035807874,
0.024452198,
0.026889384,
0.020126864,
-0.01793072,
-0.018827925,
-0.0018094761,
-0.005279452,
0.034067027,
0.022550657,
-0.0077601583,
-0.010686119,
-0.006491349,
0.0032992389,
-0.018694013,
-0.035754308,
0.009788914,
-0.0125274,
0.012507313,
-0.008242239,
0.0030330904,
-0.0095077,
0.0052526696,
0.006200092,
-0.0045931567,
-0.011924799,
-0.0034415198,
-0.025469923,
0.015533707,
-0.0052258875,
0.027933892,
0.016846038,
-0.017716462,
0.022389965,
-0.013940163,
-0.011174896,
0.009614829,
-0.010351341,
0.021010678,
-0.009521091,
-0.0034448674,
0.01993939,
-0.0059590517,
-0.001594381,
0.0058820527,
-0.006524827,
0.04156606,
-0.013685732,
0.0000015807153,
0.014837369,
0.0007582726,
0.01234662,
0.0012311467,
-0.006427741,
-0.03385277,
-0.0401466,
-0.0024187723,
0.018908272,
-0.009005533,
0.009902739,
-0.0006996864,
-0.023367517,
0.0023233606,
-0.016122917,
-0.020957114,
-0.0005561503,
-0.05677838,
0.0003958752,
-0.0041211196,
0.016564824,
-0.0073584244,
0.019323397,
-0.009065793,
0.006340699,
0.031763755,
-0.005497058,
0.010491949,
0.0077333758,
-0.016096136,
-0.03945026,
-0.014890933,
-0.004770589,
-0.038994964,
0.01556049,
-0.024666457,
-0.022831872,
0.0020823204,
-0.02518871,
0.03160306,
0.024653066,
-0.009949608,
0.018372627,
0.016377348,
0.012185926,
0.017234381,
-0.0008168588,
0.018720796,
-0.026875991,
-0.021827538,
0.040066253,
-0.0084832795,
-0.010605773,
-0.0039838604,
-0.019992953,
-0.002316665,
-0.024412025,
-0.007144166,
-0.018720796,
-0.0065616523,
0.0018630406,
0.010786553,
-0.00783381,
-0.009320225,
-0.022122143,
0.019979563,
0.00018841734,
0.0025225536,
-0.002191123,
0.00069006154,
0.008764492,
0.024760194,
-0.015573881,
-0.0053229732,
0.013873207,
-0.06449167,
-0.032004792,
-0.005460232,
-0.017569158,
0.02779998,
0.01063925,
-0.021519542,
-0.019430526,
-0.012507313,
-0.034468763,
0.01818515,
-0.02055538,
0.0016002397,
0.013806252,
-0.011409241,
-0.006749128,
0.008269021,
-0.01313,
0.033183213,
-0.0053464076,
-0.0030130036,
0.036798816,
-0.010404906,
0.018399408,
-0.011703845,
-0.012915743,
0.0037495156,
0.026942948,
-0.00038060095,
-0.0060661808,
0.02650104,
-0.031415585,
-0.00095662865,
-0.0011273655,
0.0061632665,
0.011583325,
0.027746415,
0.0065348702,
-0.039262787,
-0.014408853,
0.012487226,
0.0063607856,
0.0020237342,
0.014301724,
-0.00085242896,
-0.022363182,
0.0072512953,
-0.021171372,
-0.03291539,
0.023822816,
0.013163478,
0.016216654,
0.017662898,
0.014676675,
0.028951617,
0.01580153,
0.0002020177,
-0.0053597987,
-0.012212708,
-0.027304508,
-0.005999225,
-0.009902739,
0.0012462118,
0.01145611,
0.0004908685,
0.027826762,
-0.017274555,
-0.020100081,
0.0044927234,
0.010116996,
-0.037120204,
0.0010051714,
-0.009032316,
-0.017957501,
0.0050350637,
0.022323009,
-0.012534095,
-0.023903161,
0.0047672414,
0.00202206,
-0.026996512,
-0.017154034,
0.018881489,
-0.017140644,
0.005122106,
-0.0074320757,
-0.007090602,
0.001181767,
0.017328119,
0.18233359,
0.015105192,
0.0066687814,
0.009675089,
0.0094474405,
0.0108802905,
0.000063503234,
-0.009032316,
-0.011081158,
-0.022979174,
0.015292667,
0.021787364,
-0.0074789445,
0.0015717836,
0.015065018,
-0.005473623,
-0.012192621,
-0.02091694,
-0.011797583,
-0.013424605,
0.022296228,
-0.022764916,
0.022055186,
-0.0019551045,
0.032219052,
0.0015868485,
-0.016886212,
-0.0034314764,
0.014274942,
0.004449202,
-0.041378584,
0.012467139,
-0.012728266,
-0.013578603,
0.006983473,
0.008382846,
-0.012480531,
-0.01616309,
-0.007532509,
0.0069299084,
0.0073316423,
-0.03420094,
-0.0027267684,
0.0041244673,
-0.008536844,
-0.0025995525,
-0.00036051424,
-0.003990556,
-0.0074588577,
0.008449801,
-0.043440815,
0.00997639,
0.022242662,
0.007800332,
-0.0042249006,
-0.0028506361,
-0.00052978646,
0.017984284,
0.001519893,
0.045449484,
-0.009547873,
-0.0038432535,
-0.020983897,
0.02517532,
-0.016109526,
0.02766607,
-0.017087078,
0.015065018,
0.03489728,
-0.031790536,
0.000087042325,
0.008885013,
-0.00053020497,
-0.006688868,
-0.0047505023,
-0.015279276,
0.030933503,
0.021760581,
0.036745254,
0.023729077,
0.0091327485,
0.01313,
-0.009661699,
-0.003605561,
0.008068155,
-0.021372238,
0.02541636,
-0.004382246,
-0.0074789445,
-0.013966946,
0.018747577,
-0.013223738,
-0.0144892,
-0.010431688,
0.010498644,
-0.0011826039,
0.00997639,
-0.011964972,
-0.0053631463,
-0.01865384,
-0.029888997,
0.067330584,
0.027425028,
-0.001026932,
-0.020943724,
0.006032703,
-0.011516369,
0.0068361703,
0.0034649542,
-0.04119111,
-0.0066486946,
-0.029755084,
0.0054702754,
-0.006829475,
-0.0014236443,
0.011188286,
0.002299926,
-0.011362371,
0.03800402,
-0.0306389,
-0.00908588,
-0.055921346,
-0.012493921,
0.04028051,
0.00040278,
0.008938577,
-0.013685732,
-0.010056737,
0.0025510096,
-0.042048138,
0.014100857,
-0.014529373,
-0.0032624134,
0.02090355,
-0.0079342425,
-0.005018325,
0.012252881,
-0.013873207,
0.004974804,
-0.0040842937,
-0.008530148,
0.0031904362,
0.0066955634,
-0.0012052015,
0.020260775,
-0.0019333439,
0.022229271,
0.035781093,
-0.012226099,
-0.009360398,
-0.012487226,
-0.007150862,
0.013739296,
-0.010311168,
0.002962787,
0.0007620388,
-0.019269831,
-0.015145365,
-0.0009792262,
0.006454523,
-0.0047170245,
-0.016363958,
0.020367904,
-0.015654229,
-0.0004356301,
-0.00075869105,
-0.16862108,
0.0056677945,
-0.0052894955,
-0.012038623,
0.007385207,
0.041539278,
-0.0032021534,
-0.0023367517,
-0.005369842,
-0.002715051,
0.019417135,
-0.00064361107,
-0.041646406,
-0.034120593,
0.017662898,
0.011489587,
-0.00009290095,
0.00956796,
0.010344646,
0.02209536,
0.019859042,
-0.0268626,
0.015614054,
0.014582938,
-0.0000076175115,
0.021961449,
-0.013665645,
-0.03358495,
-0.007505727,
-0.011703845,
-0.016404131,
0.0054267542,
0.026567996,
0.005319625,
0.019042183,
0.0077266805,
-0.005999225,
-0.014141031,
-0.012266273,
0.027612504,
0.012473835,
0.038432535,
0.025844876,
-0.010612468,
0.013297389,
0.044297848,
-0.010679424,
-0.0041679884,
0.0022312966,
-0.019068966,
0.055171445,
-0.011101244,
0.026983121,
0.016604997,
0.034281287,
0.018908272,
0.0015131973,
0.011536456,
0.01794411,
-0.013217042,
0.022711352,
0.0029694824,
0.0056276214,
-0.008101632,
-0.0038164712,
-0.01900201,
-0.011549847,
0.0059858337,
-0.022041796,
0.011750714,
-0.009460831,
-0.005507101,
0.017595941,
-0.030558553,
0.016725518,
-0.012728266,
-0.011643585,
0.0023267083,
-0.00617331,
0.009681785,
0.0033477817,
0.02980865,
-0.026755473,
-0.03385277,
-0.0097085675,
-0.014234768,
0.018426191,
0.011583325,
0.0017408466,
-0.004516158,
-0.005818445,
-0.033156432,
0.024291504,
-0.0072044265,
0.029621173,
0.014167813,
0.010237517,
-0.01270818,
-0.010391515,
0.0065917824,
0.0021710366,
-0.000016856604,
-0.012922438,
0.0061130496,
0.04311943,
0.0037428201,
-0.0047940235,
0.012969307,
0.032995738,
0.011436023,
0.0024639673,
-0.0045328964,
0.01697995,
0.0034883886,
-0.005155584,
0.029192658,
-0.0032138706,
0.007090602,
0.0043956377,
-0.02921944,
0.058599573,
0.0009700198,
-0.0056744902,
0.0011223438,
-0.006949995,
-0.03053177,
-0.11302111,
-0.012514008,
0.004218205,
0.026139481,
-0.012279663,
0.011422631,
-0.00055196555,
0.031174544,
0.008269021,
0.044351414,
-0.048208058,
0.0140339015,
0.01793072,
0.016725518,
0.008262325,
0.01613631,
0.038807485,
-0.01568101,
-0.023956727,
0.01853332,
-0.010418297,
0.013766079,
-0.008416323,
-0.01617648,
-0.0055472744,
0.01021743,
-0.026956338,
0.02291222,
0.024760194,
0.0113489805,
0.0028121367,
-0.020140255,
0.023474647,
-0.010291081,
-0.030826375,
0.0005448515,
-0.014877542,
-0.02719738,
0.037816543,
-0.025014626,
0.017247772,
0.007385207,
0.020675901,
-0.007579378,
0.0033176518,
0.017676288,
-0.008094937,
0.010860204,
0.017729852,
-0.017502204,
-0.012246186,
-0.026313566,
-0.024063855,
-0.009581352,
0.02932657,
-0.029139092,
-0.012159144,
0.007278078,
-0.0086908415,
-0.010438384,
0.007820418,
0.011148114,
0.0037863413,
-0.018975228,
0.04159284,
-0.026126089,
-0.026875991,
-0.029781867,
0.035084754,
-0.015747966,
-0.0041110762,
0.006226874,
-0.021050852,
0.0029092224,
-0.016457696,
-0.00094574835,
-0.0018529972,
-0.015011454,
0.0062804385,
0.0018529972,
-0.031442367,
-0.017033514,
-0.0028723967,
-0.0027686155,
0.034870494,
0.010264299,
0.010230822,
-0.007117384,
0.03171019,
-0.0038466014,
-0.0013299063,
0.019765304,
0.013444692,
-0.002072277,
0.0041612927,
0.012848787,
0.0045831134,
-0.011308807,
-0.005938965,
0.0318441,
-0.03567396,
-0.01288896,
-0.06577722,
0.010224125,
-0.013437996,
-0.0029929169,
-0.0027887023,
-0.018720796,
-0.01317687,
-0.00712408,
0.0060829194,
0.033558164,
-0.011074462,
0.01770307,
-0.0092130955,
0.0034683018,
-0.030879939,
-0.0061465274,
0.03918244,
-0.036530994,
0.019376962,
0.01664517,
-0.006364133,
-0.0038131236,
0.028603448,
0.021224936,
-0.015533707,
-0.0045797657,
-0.0012361684,
0.0054836664,
0.020809812,
0.021358848,
0.025376186,
-0.046279736,
-0.011308807,
0.00908588,
0.00027891208,
-0.026032351,
-0.0056979246,
0.029540827,
-0.0017944111,
0.02600557,
-0.018600276,
-0.02838919,
0.015252494,
0.0011432675,
0.0019701696,
-0.010291081,
-0.02162667,
-0.003128502,
0.01122846,
-0.015587272,
0.029406914,
0.0063139163,
0.008844839,
-0.01602918,
-0.013096523,
0.011422631,
-0.002515858,
-0.021827538,
-0.005219192,
-0.013317476,
0.016886212,
0.027987456,
0.021506151,
0.02292561,
-0.00016132124,
0.0007842179,
-0.035700746,
0.01996617,
-0.005738098,
-0.040682245,
-0.024104029,
0.010130388,
0.022979174,
-0.0015290993,
-0.016203264,
-0.013792861,
-0.018131586,
-0.03288861,
-0.03302252,
0.023729077,
0.028469536,
0.009768827,
-0.008309195,
0.0067323893,
0.004024034,
-0.016832646,
-0.014194595,
0.03157628,
0.01661839,
0.009434049,
-0.013203652,
0.0041612927,
0.011034288,
0.009460831,
-0.005185714,
0.02863023,
-0.020515207,
-0.017247772,
0.0036022132,
0.03596857,
-0.017368292,
0.0018513233,
0.009413962,
-0.015292667,
0.009969695,
0.027826762,
-0.02935335,
-0.0054568844,
-0.014301724,
-0.022751525,
0.030317511,
-0.0150918,
0.004529549,
0.011991754,
-0.010050041,
-0.01910914,
0.017569158,
-0.004459245,
-0.010344646,
0.030960286,
0.004355464,
-0.00091980305,
0.0009775523,
-0.0044291154,
0.008262325,
-0.005319625,
0.021291893,
-0.013217042,
0.033156432,
-0.028014239,
0.0037294289,
0.0011014203,
-0.025362795,
0.0014772087,
-0.008349367,
-0.02591183,
0.008891708,
-0.0005720522,
-0.017609332,
0.098290876,
0.0007549248,
-0.034468763,
-0.011857843,
-0.018560102,
0.0013240477,
-0.022122143,
-0.008108327,
-0.03358495,
-0.022550657,
0.007961025,
-0.029728303,
0.009347007,
-0.018011065,
-0.00095077005,
0.017234381,
-0.011248547,
0.03564718,
0.026474258,
-0.022604223,
0.0145025905,
-0.0233943,
0.0036725167,
0.034040246,
-0.020260775,
-0.013096523,
0.031549495,
0.017408466,
0.00030590355,
-0.05369842,
0.019631393,
-0.0052827997,
-0.04028051,
0.0063607856,
-0.0024137506,
-0.015292667,
0.007411989,
-0.015761357,
0.0058586183,
0.027023295,
-0.0075994646,
0.012098883,
-0.011315502,
0.009527787,
0.004616591,
-0.025496706,
-0.0060862675,
-0.00647461,
-0.024385242
] |
In eukaryotic cells, nonhomologous DNA end joining (NHEJ) is a major pathway for repair of double-strand DNA breaks (DSBs). Artemis and the 469kDa DNA-dependent protein kinase (DNA-PKcs) together form a key nuclease for NHEJ in vertebrate organisms. The structure-specific endonucleolytic activity of Artemis is activated by binding to and phosphorylation by DNA-PKcs. We tested various DNA structures in order to understand the range of structural features that are recognized by the Artemis:DNA-PKcs complex. We find that all tested | [
-0.02035076,
0.0041464,
-0.014196949,
-0.039244037,
-0.04080948,
0.024331843,
-0.008394013,
0.02211863,
-0.009473629,
0.010398051,
0.0064642,
0.0014406125,
0.0070107556,
0.0033636782,
-0.027084863,
0.011612618,
0.020364255,
-0.008981055,
-0.0013081908,
-0.0014068744,
-0.021484356,
-0.008259062,
0.011842037,
-0.008663917,
0.024007957,
0.023279218,
0.009244211,
-0.02383252,
-0.018285993,
-0.005654488,
-0.0013739798,
0.008744889,
-0.006747599,
-0.021524841,
-0.011066062,
0.01256403,
0.018987745,
0.006174053,
0.018825801,
-0.003402477,
0.018798811,
-0.002626503,
-0.012165922,
0.00061234465,
-0.009797514,
-0.0040485593,
0.0018707719,
-0.0071659503,
-0.0018758326,
0.021470862,
-0.0016961778,
-0.00393385,
-0.016545113,
-0.010364313,
-0.02040474,
-0.006869056,
0.018893277,
-0.012051213,
0.0041700164,
-0.0027563942,
0.0012685487,
0.0027108479,
-0.022024164,
0.016261714,
-0.009689553,
0.008778626,
-0.000141067,
-0.0067374776,
0.0003074375,
-0.009035035,
0.0531171,
0.0045849937,
-0.016180743,
0.009379162,
0.010667955,
-0.030229244,
-0.02448029,
-0.0150066605,
-0.0067880847,
0.015438507,
0.0064405836,
-0.02349514,
-0.01244932,
0.008765131,
0.015371031,
-0.0025877042,
-0.009487124,
0.007914934,
0.019797456,
0.010755673,
0.02242902,
0.0122738825,
0.00040865148,
0.0058332994,
-0.04564076,
0.0013056605,
0.009918971,
0.008812364,
-0.016868997,
-0.007847458,
-0.028043022,
0.0065957783,
-0.0015527912,
-0.014709766,
-0.02009435,
-0.0033771733,
-0.011403442,
-0.015438507,
0.005070821,
0.017921623,
-0.010519507,
0.020512702,
-0.0095411055,
-0.029473513,
0.027692147,
-0.01632919,
0.024561262,
-0.017989099,
-0.016153753,
0.0017644971,
0.022132125,
0.023967473,
0.010883877,
-0.030445168,
0.029068658,
0.026045732,
0.0007536225,
0.008717898,
-0.012199659,
-0.001027322,
0.02287436,
0.0076180394,
0.03676092,
-0.0005431817,
-0.024615241,
-0.0013916923,
-0.021889212,
-0.02237504,
-0.025222525,
-0.042024046,
0.011450676,
0.019203667,
-0.014925689,
0.009709795,
-0.002660241,
0.0094938725,
0.02751671,
-0.010107904,
0.0105869835,
0.021403385,
0.028447878,
0.0021322414,
0.0014878457,
-0.014156464,
0.00032008922,
0.0139945205,
-0.008049886,
0.01666657,
-0.01793512,
-0.020202313,
-0.0063258745,
-0.014453357,
0.0122738825,
-0.026005248,
0.039298017,
0.038299374,
-0.021983678,
0.010053922,
0.0039507193,
-0.029581474,
0.005188904,
0.019433085,
-0.032442458,
0.015883848,
-0.021794746,
0.01177456,
0.0018606505,
0.021686783,
-0.037921507,
-0.003518873,
0.011066062,
-0.0017054557,
0.035168488,
-0.009534358,
-0.010991839,
0.0033957292,
0.0031325729,
-0.018798811,
-0.01037106,
0.009089016,
0.015870353,
-0.0035087515,
-0.033522073,
-0.031119928,
-0.62747276,
-0.02692292,
0.006049223,
-0.0244533,
0.003481761,
0.028906714,
0.025627382,
0.01843444,
-0.008380518,
0.00670374,
-0.031362843,
-0.0065957783,
0.012105193,
0.001985481,
-0.056247987,
-0.016153753,
0.004190259,
-0.010883877,
0.02858283,
0.009561348,
-0.0010543123,
-0.010613973,
-0.00390686,
-0.0056781047,
0.013954035,
-0.017354826,
0.028447878,
-0.013272528,
-0.0073953685,
0.005506041,
-0.023522131,
0.015843363,
-0.03587024,
0.022213096,
0.047044262,
0.009993195,
0.0012609576,
0.03549237,
0.0076180394,
0.054952446,
-0.016922979,
0.004092419,
0.017165892,
0.020688139,
0.0030364196,
0.001473507,
0.025263011,
-0.019190172,
0.004210502,
-0.0032574036,
0.012597768,
-0.003552611,
0.009561348,
0.012496553,
-0.010883877,
0.031578764,
0.009649067,
-0.004851524,
0.011153782,
0.009338677,
0.0048177857,
0.012975633,
-0.025074078,
-0.022294067,
-0.026518065,
-0.018056575,
-0.016437152,
0.012152426,
0.011093053,
-0.0052968655,
0.023481645,
0.011558637,
0.021848727,
-0.0018134173,
-0.0050235875,
0.029851379,
0.012435826,
-0.0019196919,
-0.022901352,
0.005064073,
-0.010640964,
-0.021241441,
-0.017773176,
-0.0010357564,
0.031551775,
-0.020121342,
-0.0070917266,
0.027638167,
0.011538395,
0.007962167,
0.009628824,
-0.0031595633,
-0.0015612257,
-0.017233368,
-0.0107624205,
0.017071426,
-0.006885925,
-0.00602898,
-0.00882586,
-0.031200899,
-0.009932466,
-0.013670636,
0.000837124,
-0.026086219,
-0.0018151042,
0.0032405346,
-0.045235906,
-0.010640964,
0.04628853,
-0.027098358,
-0.015505983,
-0.022779895,
0.0070917266,
-0.007510078,
0.00854246,
-0.02512806,
0.03743568,
-0.011929755,
0.011072811,
-0.019244153,
0.003080279,
-0.015060642,
-0.0049257474,
-0.032118574,
0.02995934,
0.0055465265,
-0.001769558,
-0.025559906,
-0.012051213,
-0.0050438303,
0.010573488,
0.00820508,
0.012260388,
-0.007840711,
0.008090371,
-0.01593783,
-0.003265838,
0.008940569,
0.022833876,
-0.028447878,
-0.005516162,
0.0024341964,
-0.0008421847,
0.007692263,
0.000083606974,
-0.015816372,
-0.04232094,
0.0010990152,
0.013819084,
0.02375155,
0.013805588,
0.004308342,
-0.015303555,
0.0077732345,
0.0030364196,
-0.007442602,
-0.017138902,
-0.011113296,
-0.021119986,
-0.006572162,
0.0058670375,
0.006383229,
-0.010357564,
0.004949364,
-0.00885285,
-0.01661259,
0.029311571,
-0.012159173,
-0.015249575,
-0.022739409,
0.0036605725,
0.011632861,
-0.03209158,
0.008792122,
0.023576112,
0.030121284,
-0.010856887,
0.0018134173,
0.0006865682,
0.0013638585,
-0.01669356,
-0.022928342,
-0.020526197,
-0.027260302,
0.021403385,
0.021039015,
0.03527645,
0.0244533,
0.0095546,
0.017800167,
-0.014008016,
0.011491162,
0.0111807715,
0.0068150754,
0.008960811,
-0.024399318,
0.023036303,
0.028177975,
-0.0009902102,
0.034385767,
0.033711005,
-0.02102552,
0.010661207,
-0.020188816,
0.013218547,
-0.014561319,
-0.0048548975,
-0.005890654,
0.018002594,
-0.00038229366,
-0.009831252,
-0.007854206,
-0.017665215,
-0.01936561,
0.0123548545,
0.0028660428,
-0.018366965,
-0.00097418466,
0.009534358,
0.0041497736,
-0.011194267,
-0.02751671,
0.024264367,
-0.0043859393,
0.0018876409,
0.015263069,
0.034250814,
0.04151123,
0.00921722,
-0.0013098777,
0.0012921653,
0.022955332,
-0.01869085,
0.0075708064,
0.013758355,
0.002641685,
0.02858283,
0.0019922287,
0.0132860225,
-0.004558003,
-0.007941924,
-0.0064878166,
-0.004159895,
-0.0022165864,
0.022982324,
-0.0104250405,
0.017665215,
0.020188816,
-0.003991205,
0.01767871,
-0.016234724,
-0.0051821563,
-0.030526139,
0.023279218,
-0.003819141,
-0.03667995,
0.0014018137,
0.04483105,
0.04690931,
0.01765172,
0.002930145,
-0.010681449,
0.01022936,
0.0089945495,
0.010209118,
-0.029527495,
0.010290089,
0.0011664912,
-0.015398022,
-0.00024649824,
-0.0065924046,
-0.00854246,
0.002643372,
-0.025937771,
0.004450042,
0.010701693,
0.01874483,
0.021012023,
0.03125488,
0.0002365877,
-0.016369676,
-0.036329076,
0.023009313,
0.027030881,
0.000853993,
-0.007341388,
-0.019595029,
0.008124109,
0.001867398,
0.029473513,
-0.005870411,
0.037084807,
0.016059287,
0.016356181,
-0.022955332,
-0.023873005,
0.025559906,
-0.01978396,
0.027935062,
-0.01672055,
0.00508769,
-0.004635601,
-0.0076855156,
-0.009277949,
0.049905244,
0.006042475,
0.017921623,
-0.001237341,
0.01672055,
-0.037003834,
-0.014696271,
-0.015829869,
-0.008043138,
-0.021349404,
-0.021929698,
-0.0069567747,
-0.021619309,
-0.0038697482,
0.028285936,
0.022739409,
-0.027314281,
-0.025047088,
-0.00747634,
-0.017948614,
0.031956628,
0.009062026,
-0.0048920093,
0.009918971,
0.004831281,
-0.004456789,
-0.00026252377,
-0.013259033,
0.033576053,
-0.009365668,
-0.008461489,
-0.015438507,
-0.013245537,
0.005374463,
0.005037083,
0.03686888,
0.0056916,
-0.02040474,
-0.00328102,
-0.0035323682,
-0.0011555264,
-0.009858242,
0.03419683,
0.03284731,
0.028366907,
0.0115181515,
0.020607168,
-0.006902794,
0.019244153,
-0.017489778,
-0.0034716397,
0.01593783,
0.0112415,
0.029311571,
-0.009304939,
-0.042185992,
0.00065156503,
-0.00029984643,
0.0077327485,
0.0032202918,
0.013805588,
0.0067610946,
0.0077057583,
0.012516797,
0.011909513,
-0.023535626,
0.0050944374,
0.0005967408,
-0.03616713,
0.006848813,
0.019608524,
-0.023454655,
-0.02209164,
-0.026410103,
0.0062212865,
-0.0025910782,
-0.008286051,
-0.0057590757,
-0.022955332,
-0.026612531,
0.0131105855,
-0.013846073,
-0.00055077276,
-0.010499264,
-0.0028390524,
-0.019972894,
-0.0255734,
-0.01796211,
-0.012678739,
-0.02551942,
0.0010112964,
-0.024196891,
-0.039244037,
-0.00092020386,
0.032766342,
0.013333256,
0.034871593,
-0.01275971,
-0.006109951,
0.015519478,
-0.017530262,
-0.008886588,
0.0021322414,
-0.02489864,
-0.039864816,
0.00798241,
-0.015452002,
-0.011207762,
-0.008677413,
0.0009151431,
0.023238732,
-0.00081013364,
0.015897343,
-0.006109951,
-0.020985033,
0.017071426,
0.020472215,
0.039864816,
-0.0012584273,
0.015492488,
-0.0051281755,
-0.03327916,
-0.032766342,
-0.024088928,
-0.005924392,
-0.016072782,
0.009534358,
0.007699011,
-0.0052293893,
-0.012840682,
0.0013174687,
-0.0038461315,
0.011585628,
0.0037111796,
0.038380343,
0.021457365,
-0.008272557,
0.010971596,
-0.01801609,
0.0016928039,
-0.008272557,
-0.03419683,
0.018110557,
0.018191528,
-0.0063528647,
0.016315695,
0.016450647,
-0.013812335,
-0.0010753986,
0.004760431,
-0.0010306957,
0.026086219,
-0.0015839989,
-0.018178033,
0.027989041,
-0.015613944,
-0.020931052,
0.0066430112,
0.016801521,
0.011423686,
-0.013981026,
0.0102968365,
0.012867671,
-0.015802877,
-0.025937771,
-0.03325217,
-0.0150066605,
0.021376394,
-0.017476281,
0.0012103507,
-0.013151071,
-0.022307564,
0.0022773147,
-0.019595029,
-0.013900055,
-0.035789266,
0.024588251,
0.0052934918,
0.037786555,
0.041862104,
0.02995934,
-0.006835318,
0.004446668,
0.0230498,
0.0065856567,
-0.010114651,
-0.010694944,
0.0071187173,
-0.01208495,
0.023454655,
0.012793448,
-0.017894633,
0.0024999855,
0.0074358545,
0.022267077,
0.0146153,
-0.011949998,
-0.03182168,
0.014453357,
-0.05290118,
-0.0015679734,
-0.0034648923,
-0.0054115746,
-0.015694916,
-0.02448029,
0.015074137,
0.014561319,
0.0037145533,
0.01871784,
-0.012327864,
0.027462728,
-0.001068651,
0.030175263,
-0.02043173,
0.026626026,
-0.018879782,
0.0009682805,
0.0051720347,
0.018501917,
0.004713198,
0.0054453127,
0.027192825,
-0.008218576,
0.0036841892,
-0.016545113,
0.022644943,
-0.0030684706,
-0.011086306,
-0.00072072796,
-0.030256234,
-0.0013773537,
-0.0017881137,
-0.0035829751,
-0.048717666,
0.00020337685,
0.004450042,
0.011194267,
0.012091698,
0.00096743705,
-0.010026933,
0.036248103,
-0.009109259,
0.019851437,
-0.021227947,
0.0108433915,
0.032496437,
0.016491132,
-0.0340079,
-0.014736757,
-0.0038663743,
0.0008109771,
0.017975604,
0.015249575,
0.0012010727,
-0.01869085,
-0.013846073,
-0.019014735,
-0.010964849,
-0.040593557,
0.0123548545,
-0.02250999,
0.0068083275,
0.003923729,
0.016234724,
0.006359612,
0.01430491,
-0.0031241383,
0.029068658,
0.0062314076,
0.0041801375,
-0.018097062,
0.018151041,
0.0013655454,
0.02694991,
-0.024885146,
-0.017800167,
-0.00003297362,
-0.024669223,
0.0043285848,
-0.0129014095,
0.01155189,
0.03341411,
-0.017800167,
-0.0034227197,
0.011302229,
0.00046516262,
-0.0013942227,
-0.011369704,
0.012989128,
0.038542286,
-0.014993166,
0.0026467459,
0.034250814,
0.012051213,
-0.009689553,
0.0062887627,
-0.0042509874,
-0.0067273565,
-0.0387852,
0.007240174,
0.017530262,
0.01020237,
-0.000812664,
-0.02344116,
-0.017746186,
-0.0018539028,
-0.026032237,
-0.023616597,
0.021956688,
-0.059001006,
-0.025033593,
0.00074392284,
0.0033417486,
0.022901352,
0.0050033447,
0.010944606,
-0.0010905807,
0.031524785,
0.00005640571,
-0.0010205744,
0.0048616454,
0.016126761,
-0.012658496,
0.0062853885,
-0.010101156,
-0.020418236,
0.025762334,
-0.010802906,
-0.015870353,
-0.000812664,
-0.013225295,
0.019568037,
0.01734133,
-0.019379105,
0.019959398,
-0.013474955,
0.02372456,
0.0105869835,
-0.024196891,
0.006251651,
-0.025384469,
-0.008178091,
0.012429078,
-0.0150876315,
-0.033711005,
-0.009385911,
-0.01531705,
-0.008954064,
-0.0039642146,
-0.008306295,
-0.022240087,
-0.00680158,
-0.0011951685,
0.0027631419,
0.010836644,
-0.015667925,
-0.036571987,
-0.0051990254,
0.012597768,
-0.011707084,
0.014763747,
0.006163932,
0.011788056,
0.02515505,
-0.02858283,
0.00088224857,
0.0008063381,
-0.02858283,
-0.031740706,
-0.000038429687,
-0.0016295452,
0.03676092,
0.014871709,
-0.025074078,
-0.018097062,
-0.022051154,
-0.02546544,
-0.036787912,
-0.036814902,
0.005151792,
0.017611234,
0.033791978,
0.017381815,
0.011228005,
0.012725972,
0.001835347,
-0.012678739,
-0.018852793,
0.02577583,
-0.031767696,
0.010269846,
0.0059480085,
-0.035978198,
-0.011713833,
0.02847487,
0.00025830654,
-0.009878485,
0.003432841,
0.00024207012,
0.015114622,
0.010276593,
-0.009008045,
0.004831281,
0.04226696,
-0.0028238702,
-0.026059229,
-0.020526197,
-0.012712477,
-0.009223968,
-0.0331712,
0.013340004,
-0.003822515,
-0.0011378139,
0.0040451856,
-0.0072604166,
-0.013137575,
0.0033771733,
-0.039298017,
0.021173967,
-0.005195651,
-0.0009851495,
0.030661091,
0.007557311,
-0.009831252,
-0.010931111,
-0.00820508,
-0.02453427,
-0.008636927,
-0.0066227685,
-0.011713833,
-0.0071996883,
-0.011072811,
-0.010330575,
-0.015263069,
-0.0015983375,
0.011254995,
-0.0043319585,
-0.012260388,
0.01708492,
0.009858242,
0.002859295,
-0.018488422,
0.026747484,
-0.0028744773,
0.0019652382,
0.0030617232,
0.009136249,
0.008387266,
0.0070647364,
0.01464229,
-0.026680008,
-0.015978314,
0.0051990254,
-0.009932466,
-0.014817728,
0.009379162,
0.19357513,
0.00602898,
0.0053238557,
0.020472215,
0.008097119,
-0.012300873,
-0.0049527376,
0.00164051,
-0.011976989,
-0.0047098245,
0.021686783,
0.009257706,
-0.03797549,
-0.007699011,
0.039675884,
-0.009905475,
-0.016922979,
-0.0062550246,
-0.0112415,
-0.0027715764,
0.0034716397,
-0.005468929,
0.009804262,
-0.002881225,
0.014318406,
-0.008927073,
-0.015667925,
-0.0032304132,
-0.008414256,
0.012752962,
-0.022483,
-0.004831281,
0.013022866,
-0.016922979,
0.015114622,
-0.0014254303,
-0.012847429,
0.0030617232,
0.0070917266,
-0.0060323537,
0.0035053778,
-0.025748838,
-0.014817728,
-0.011281986,
-0.0064439573,
-0.019554542,
-0.007874448,
-0.021281928,
-0.009048531,
0.014210444,
-0.05694974,
-0.009352173,
0.013981026,
0.021308918,
-0.010917615,
0.0028086882,
0.010026933,
0.0075033302,
-0.007510078,
0.03859627,
0.0041160355,
0.011923008,
-0.010910868,
0.013245537,
-0.020877073,
0.013366994,
-0.017773176,
0.0024173274,
0.04221298,
-0.0042239972,
-0.010985091,
-0.0002859295,
0.0014203696,
-0.0107624205,
-0.0067442255,
-0.017638225,
0.045478817,
0.02250999,
0.021578822,
0.0038764956,
0.020971538,
-0.0060795867,
-0.003927103,
0.009473629,
-0.0029638829,
-0.0050573256,
0.019608524,
-0.009601833,
-0.020053865,
-0.011842037,
-0.00029056848,
0.0001536133,
-0.02653156,
-0.016423656,
-0.011970241,
-0.0015527912,
-0.005556648,
0.0056511145,
-0.009777271,
-0.0067813373,
-0.029797398,
0.07012105,
-0.0002893033,
0.011565385,
-0.019797456,
0.0041700164,
0.012698982,
0.017665215,
0.0029250842,
-0.013380489,
0.037894517,
-0.021241441,
0.0056140027,
-0.012962138,
-0.00713896,
0.019824447,
0.0059648775,
-0.027665157,
0.036302082,
-0.013373742,
0.007860953,
-0.02209164,
-0.017692205,
0.043265607,
-0.0026686755,
0.0028086882,
-0.016531618,
-0.0024122668,
-0.010937858,
-0.034304794,
-0.012314369,
-0.004851524,
0.031956628,
-0.0059682513,
0.0032000488,
-0.017098416,
0.017300844,
-0.010647711,
-0.016936474,
0.015546469,
0.0048751403,
-0.006750973,
0.016788026,
0.021970183,
-0.0057793185,
-0.017125407,
0.026828455,
0.013731364,
-0.025236022,
-0.0024628737,
-0.021146975,
-0.006626142,
-0.00747634,
0.02074212,
0.0043319585,
-0.021646298,
-0.0193926,
-0.044129297,
-0.0051450445,
0.014129473,
-0.044588134,
0.019595029,
0.023643587,
-0.013002624,
-0.009466882,
0.016315695,
-0.17068727,
0.0013579543,
0.013859569,
-0.03060711,
0.023913492,
0.034925573,
0.015600449,
0.0020748868,
0.013171313,
0.003603218,
0.018825801,
0.016680066,
-0.053575937,
-0.047395136,
0.009952709,
0.011902765,
0.020823091,
0.0051484182,
0.026747484,
0.0056882263,
0.008987802,
-0.0048177857,
0.01902823,
0.00062837015,
0.008441247,
0.011848784,
-0.0021524841,
-0.021821735,
0.0036808155,
0.0018741457,
-0.008002653,
0.018758325,
0.028285936,
0.0019230657,
0.005219268,
0.00039304767,
-0.0029571354,
0.024237376,
0.004628853,
0.029608466,
0.012132184,
0.027827099,
0.019716484,
-0.009993195,
0.0075438158,
0.00039916267,
-0.001835347,
-0.0067644683,
0.012523544,
0.0034092246,
0.017543757,
-0.0074156113,
0.031605754,
0.014966175,
0.036949854,
0.0038123936,
-0.0060154847,
0.018339975,
0.0014490469,
-0.005391332,
0.018582888,
-0.0065417974,
0.036437035,
-0.010917615,
0.0060087373,
-0.015748896,
0.0036065918,
0.018259004,
-0.04620756,
0.022132125,
-0.015559964,
0.0028525474,
0.012941895,
-0.00022773148,
0.023171255,
-0.00887984,
-0.009736786,
0.027827099,
-0.001869085,
-0.036194123,
-0.0059108967,
0.021902706,
-0.023967473,
-0.033090226,
0.002589391,
-0.017813662,
0.002425762,
0.008184838,
-0.010276593,
0.021538336,
0.02653156,
-0.043913376,
0.013582917,
-0.00040780802,
0.033791978,
0.017773176,
-0.007699011,
-0.020890567,
0.009406153,
0.0064709475,
-0.0026534933,
-0.0030043686,
-0.004865019,
0.02144387,
0.028366907,
0.014628795,
0.020580178,
-0.0079014385,
0.031605754,
0.027395252,
-0.019649008,
-0.028097004,
0.018960753,
0.03268537,
0.013373742,
0.034466736,
-0.00863018,
0.016437152,
-0.0029740043,
-0.04550581,
0.08885238,
0.0011057628,
-0.011430433,
-0.0030431673,
0.021551833,
-0.027530205,
-0.11789405,
-0.0060897083,
0.0066598803,
0.03527645,
-0.00085905375,
0.005539779,
0.006484443,
0.04021569,
-0.02240203,
0.02037775,
-0.027665157,
-0.0027209693,
0.006747599,
-0.013927044,
-0.0047401884,
0.01672055,
0.006234782,
-0.01596482,
-0.0037179273,
0.033468094,
-0.0018134173,
0.0053575938,
0.019338619,
-0.013205051,
0.017746186,
0.008623431,
-0.022671934,
0.029338561,
0.0165856,
0.0074358545,
-0.007300902,
-0.0165856,
-0.008582946,
-0.005539779,
-0.041646183,
-0.033899937,
-0.012381844,
-0.024318347,
0.039190058,
-0.009183482,
0.0031882406,
-0.006497938,
0.013299518,
-0.009682805,
0.022806885,
0.005897402,
-0.00045588467,
-0.0015485741,
0.002810375,
-0.0072671645,
-0.038542286,
-0.010917615,
-0.032550417,
-0.01177456,
0.016167248,
0.009574844,
0.0069770175,
0.0049594855,
-0.008805617,
-0.014318406,
-0.0150876315,
-0.01312408,
0.005303613,
0.0024831165,
0.025478935,
-0.012570777,
-0.025762334,
-0.026261656,
0.032712363,
0.006376481,
-0.005222642,
0.005711843,
-0.013967531,
-0.0056612357,
-0.014601804,
-0.0139945205,
-0.02201067,
-0.010748926,
-0.0004866706,
-0.0014178393,
-0.004865019,
-0.028933706,
0.0030364196,
-0.014466853,
0.0034648923,
0.004531013,
0.008434499,
-0.0033282533,
0.027287291,
-0.008805617,
-0.014196949,
0.009979699,
-0.0023447906,
-0.014912195,
-0.003873122,
0.008124109,
-0.0002095973,
-0.025789324,
0.008987802,
0.010452031,
-0.018178033,
0.007361631,
-0.06385928,
0.012523544,
-0.0055195363,
-0.010458779,
0.01259102,
-0.015532973,
0.010114651,
0.0003635269,
0.016234724,
0.0033096974,
-0.024615241,
0.00073253625,
-0.017408807,
-0.0063697337,
-0.026005248,
-0.0007249452,
0.013697626,
-0.012833933,
-0.0071119694,
0.01708492,
-0.00885285,
-0.009055278,
0.01998639,
0.018893277,
0.0025387842,
-0.00622466,
-0.020647654,
-0.011018829,
-0.0075505637,
0.0056882263,
0.0028323047,
-0.050553013,
-0.029743418,
-0.002056331,
0.0036065918,
-0.005404827,
-0.035114504,
0.022604458,
0.022064649,
0.0153440405,
-0.032550417,
-0.04080948,
-0.0054588076,
0.0034463364,
0.0014920628,
-0.0018218518,
-0.02582981,
0.0074830875,
-0.009561348,
-0.015263069,
0.028771764,
0.009655815,
-0.0041700164,
-0.018339975,
-0.024763688,
0.0077732345,
0.00088224857,
-0.015573459,
-0.020161826,
-0.0382184,
0.0076315347,
0.016868997,
0.00044702843,
0.0034952564,
-0.014574815,
-0.0105869835,
-0.019527553,
-0.014142968,
-0.014210444,
-0.02380553,
-0.010485769,
0.02751671,
0.0032776464,
0.0027142218,
-0.014723262,
-0.008643675,
-0.024939127,
-0.0064709475,
-0.019122696,
0.011572133,
0.010209118,
-0.017435797,
-0.008279304,
0.0261402,
0.016356181,
-0.009736786,
0.011221257,
0.021902706,
-0.0005495076,
0.01700395,
0.012577525,
0.023373684,
0.022145621,
0.018879782,
-0.0014001268,
0.02116047,
-0.019824447,
-0.017462786,
0.0049392427,
0.013198304,
-0.0071119694,
-0.013360246,
0.02653156,
-0.0050134663,
-0.000109543056,
0.03133585,
-0.024250872,
-0.023886502,
0.008643675,
0.0022790015,
0.011558637,
0.0025792697,
0.0027698895,
0.015263069,
-0.0051281755,
0.024007957,
0.021349404,
-0.0068285703,
-0.015870353,
0.024952622,
0.022590961,
0.022064649,
0.0018943885,
0.004281352,
0.03883918,
0.012334611,
0.027746128,
-0.012300873,
0.021484356,
-0.00935892,
0.03943297,
-0.0049088784,
-0.017692205,
-0.008164595,
-0.015371031,
-0.010256351,
0.015276564,
0.01804308,
-0.024264367,
0.095707946,
0.02847487,
-0.021997174,
-0.011308976,
-0.031740706,
0.014871709,
-0.00279688,
0.002069826,
-0.018232012,
-0.022671934,
0.018515412,
-0.029203609,
0.024318347,
-0.0292306,
0.01191626,
0.018447936,
-0.0058467947,
0.01529006,
-0.024979612,
-0.036248103,
0.014088987,
-0.011322471,
-0.01838046,
0.024345338,
-0.020242797,
0.024912136,
0.022469506,
-0.007186193,
0.024250872,
-0.016315695,
0.0032557165,
-0.023292713,
-0.018312985,
-0.0038630005,
0.012118688,
0.011585628,
-0.0009792453,
-0.023643587,
0.03454771,
0.009291444,
0.0035728537,
0.013178062,
-0.0018370339,
-0.036275093,
0.008022895,
0.0018741457,
-0.020013379,
0.013751607,
-0.015789382
] |
Taro bacilliform virus (TaBV) is a pararetrovirus of the genus Badnavirus which infects the monocotyledonous plant, taro (Colocasia esculenta). A region of the TaBV genome spanning nucleotides 6,281 to 12 (T1200), including the 3′ end of open reading frame 3 (ORF 3) and the intergenic region to the end of the tRNAmet-binding site, was tested for promoter activity along with four different 5′ deletion fragments (T600, T500, T250 and T100). In | [
-0.029416213,
-0.030503688,
-0.009590175,
-0.016719935,
-0.017073365,
0.003925107,
-0.013199234,
-0.03517983,
-0.039964724,
0.0077142795,
0.009046437,
0.0073404596,
0.0029072978,
-0.017821005,
0.0104125785,
0.025215838,
0.006110253,
-0.009882433,
-0.0029531757,
-0.008828942,
-0.016434474,
0.01752195,
-0.01642088,
-0.009250338,
0.0014290108,
0.011996214,
-0.0051077367,
-0.03311363,
-0.011690361,
0.0009948702,
0.012308863,
-0.0076123285,
-0.009338696,
-0.011316542,
-0.0015734411,
-0.03923068,
0.007741466,
-0.007653109,
0.0025470715,
0.0128933815,
0.013233217,
0.009229949,
0.0019982362,
0.010337814,
-0.016216978,
-0.02830155,
0.020417353,
-0.012906975,
-0.010895145,
0.03039494,
0.021355301,
-0.0015513517,
-0.00012658894,
0.0024417224,
0.0046829414,
0.030095885,
0.013770158,
-0.0063685286,
0.0027628674,
-0.04026378,
-0.0014901813,
0.0058519775,
-0.016271353,
-0.0046931366,
-0.005264061,
0.019900803,
0.0026881036,
0.0039488953,
-0.019098788,
0.009284322,
0.022619491,
0.02191263,
-0.003180866,
-0.0034153527,
0.01930269,
-0.025011936,
-0.055325318,
0.0017246682,
-0.010004775,
0.020254232,
0.019792054,
-0.010093132,
-0.014313896,
0.018636612,
0.0018317165,
0.0059165466,
0.0013839825,
0.002710193,
-0.02040376,
-0.005015981,
0.02782578,
0.037789773,
0.00026719613,
0.01689665,
-0.013647818,
0.0013440518,
-0.009467834,
0.042520292,
-0.01428671,
-0.03479922,
-0.005420386,
-0.0034204503,
-0.0118195,
-0.013681801,
-0.018473491,
0.018527864,
0.0062291957,
-0.007326866,
0.014042027,
-0.009325103,
-0.035777945,
0.04578272,
-0.01598589,
-0.047740176,
0.005077151,
0.017780224,
0.0350439,
0.0060320906,
-0.009739703,
0.003632848,
0.010473749,
0.013185641,
0.0047848923,
-0.018188028,
0.037599467,
-0.019411437,
-0.024237111,
-0.009862044,
-0.00045622996,
-0.0066471943,
0.041704684,
0.035560448,
0.008876519,
0.0045673973,
-0.0016923838,
0.0075103776,
-0.047685802,
-0.018174434,
-0.01225449,
-0.02865498,
0.0051451186,
0.02541974,
-0.016665563,
-0.0088697225,
0.011078657,
0.0030143461,
0.016312134,
0.021817477,
0.008495903,
-0.010038759,
0.0063107563,
-0.018255996,
0.01930269,
-0.020757189,
0.0054169875,
0.005015981,
-0.020104704,
0.021015463,
0.0034136537,
-0.00781623,
-0.0074899876,
0.019289097,
0.0075035812,
-0.002344869,
0.021831071,
0.022565117,
0.0030942077,
-0.021124212,
-0.01729086,
-0.01839193,
-0.0028580215,
0.0069156648,
-0.0076667024,
0.011663175,
0.005590304,
0.010147505,
-0.018922074,
0.015170284,
0.0071705417,
-0.007843417,
-0.028546233,
0.0003037285,
0.026031446,
-0.0039149118,
-0.028519046,
-0.005311638,
0.007700686,
-0.0045368117,
-0.01397406,
-0.01152724,
-0.004618373,
0.010018368,
0.020770783,
0.0068341037,
-0.64161056,
-0.030014325,
0.010398985,
0.002871615,
-0.0031774675,
0.006286968,
0.015700428,
-0.0009396468,
-0.011037877,
0.007598735,
-0.014857634,
-0.020906717,
0.022524336,
0.0082987975,
-0.021572795,
-0.036403242,
-0.002954875,
0.006704966,
0.023951648,
0.0145721715,
-0.027485944,
0.023625406,
-0.001656701,
0.011948637,
0.0035444906,
-0.011180608,
0.004601381,
-0.0294434,
0.00096853287,
0.027132515,
-0.013382746,
0.032189276,
0.011792312,
-0.01739961,
0.041894995,
-0.008224034,
-0.026507216,
0.012356441,
0.023706967,
0.017861785,
-0.019452218,
0.00025976222,
0.019316284,
-0.019275503,
-0.021844665,
0.033222377,
0.0155101195,
-0.018487083,
-0.0030160453,
-0.014912008,
0.008828942,
-0.002749274,
0.0009566386,
-0.011275762,
0.00019338798,
0.006562235,
0.014069214,
-0.0025062913,
0.016801497,
-0.0052674594,
-0.018813327,
0.0155101195,
0.014218742,
-0.0029106962,
-0.015455746,
-0.022442777,
-0.033331126,
0.03517983,
0.0047848923,
-0.0196969,
0.013076893,
0.004907233,
0.005872368,
-0.004088228,
0.025283806,
0.060409263,
0.016339319,
-0.003530897,
-0.012376831,
0.0154421525,
0.0029616717,
0.0047373152,
-0.010854365,
0.0033269953,
0.032270838,
0.0017824403,
-0.043172777,
0.046163335,
0.019289097,
-0.012281677,
0.026180973,
0.008740584,
-0.015279031,
-0.0058995546,
-0.00072555005,
-0.0021902437,
-0.00698703,
-0.011017486,
-0.0044348612,
-0.0017518551,
-0.011969027,
0.00019816692,
0.017617103,
-0.00590975,
0.010303831,
-0.007979351,
-0.019968769,
-0.002288796,
0.026819864,
-0.033711743,
-0.017834598,
-0.016216978,
-0.0090056565,
-0.0010390489,
0.013389542,
-0.033494245,
0.009760093,
0.00088697224,
-0.008060913,
-0.021926224,
0.01681509,
0.020145483,
0.003979481,
0.0017994321,
0.0055223363,
0.019628933,
0.020498913,
-0.0410522,
-0.008067709,
-0.022429183,
-0.014585765,
0.0032114512,
0.017780224,
-0.000993171,
0.03259708,
0.00029926817,
0.013002129,
0.008781365,
-0.017114146,
-0.027417976,
-0.03031338,
-0.02305448,
0.00827161,
0.012852601,
-0.010161099,
-0.021681543,
0.0072521023,
0.023829307,
-0.021899039,
0.027499536,
0.03653918,
-0.010793194,
-0.004669348,
-0.010548512,
0.0344186,
-0.011846687,
-0.018120062,
-0.032923322,
-0.010609683,
0.016529627,
0.0155101195,
-0.003201256,
0.010725227,
-0.0013635923,
0.019058008,
-0.012302067,
0.001397576,
0.016706342,
-0.006861291,
-0.03547889,
0.0084007485,
-0.035614822,
-0.0031995568,
0.010630073,
-0.008862926,
0.015346998,
-0.0061510336,
-0.0003491816,
-0.016624782,
-0.016216978,
-0.008774568,
0.0049208268,
0.002013529,
-0.014232336,
0.002560665,
-0.0010721829,
0.007088981,
0.012866194,
0.020784376,
-0.0005632783,
0.015129503,
0.013090487,
-0.005828189,
0.014463425,
0.0105757,
-0.006837502,
0.024413826,
0.034391414,
0.011608801,
0.019193944,
0.0026932012,
0.014993569,
0.007877401,
-0.02179029,
-0.010602886,
-0.031835847,
-0.0028308346,
-0.03189022,
0.012607919,
0.017698664,
0.016162604,
-0.008278407,
-0.015034349,
0.019547373,
0.0044586495,
0.00864543,
0.01103108,
0.0006354935,
0.0018809928,
0.0023567632,
-0.025338179,
0.013668207,
-0.0011970727,
-0.029987138,
-0.010895145,
0.022252468,
-0.0066471943,
0.021871852,
0.0023975438,
-0.016053857,
0.00943385,
-0.0054747597,
0.013307981,
0.027703438,
0.014585765,
-0.025841137,
0.01716852,
0.0039590904,
0.040834706,
0.014191556,
-0.027893746,
0.015047942,
-0.0026728108,
0.005094143,
0.026751898,
0.0028563223,
0.008896909,
0.009896027,
-0.014028434,
0.0022650077,
-0.012003011,
0.0026898028,
-0.02794812,
-0.006042286,
-0.00337967,
-0.020322198,
-0.010065945,
0.0387685,
0.03458172,
0.015646053,
0.029660895,
-0.008346374,
-0.008489106,
0.008067709,
0.023108855,
-0.012043791,
-0.0008015884,
-0.0124583915,
0.0035954658,
0.008461919,
-0.0042479513,
0.000034275658,
-0.0023482675,
-0.026235348,
0.0023108853,
0.014395457,
-0.027975308,
0.017005399,
-0.004557202,
-0.0017221194,
-0.029579334,
-0.05040449,
0.020933904,
-0.0044688447,
-0.012974942,
-0.023693373,
-0.010568903,
-0.0038333512,
-0.015265438,
0.016352912,
0.007952165,
0.030530876,
0.020743595,
0.020539694,
-0.009800873,
-0.008495903,
0.0075919386,
-0.011697158,
-0.0017450583,
-0.0011537436,
-0.0030772157,
-0.011357322,
0.006861291,
-0.016271353,
0.030775556,
0.011996214,
0.017467575,
0.028899662,
-0.010453358,
-0.009705719,
0.019941581,
-0.021926224,
0.0030143461,
-0.017617103,
-0.016978212,
0.037871335,
-0.007306476,
0.008026929,
0.035152648,
0.0041086185,
-0.017386016,
-0.015279031,
-0.0003481196,
0.0012616415,
0.006307358,
0.014789667,
-0.01816084,
0.0037823757,
0.0043499023,
0.028981222,
-0.017630696,
-0.040644396,
0.0032114512,
-0.009916417,
0.006025294,
-0.0230137,
0.0246721,
0.0025776569,
0.02459054,
0.024087582,
-0.006371927,
-0.024780849,
0.024998343,
0.021205772,
0.0054373774,
-0.007523971,
-0.010419374,
0.049833566,
0.016461661,
0.012064181,
0.006066074,
0.019438624,
0.02743157,
-0.011425289,
0.0050805495,
0.013158454,
-0.007041404,
0.014993569,
0.0047950875,
-0.026398469,
0.01312447,
0.032433957,
-0.024808034,
0.033358313,
0.03343987,
0.041378442,
0.0143682705,
0.008088099,
0.0022344224,
-0.014803261,
-0.0028648183,
-0.003437442,
0.0045809904,
-0.025310993,
0.033684555,
-0.005281053,
0.002258211,
-0.026194567,
0.003002452,
-0.0017824403,
-0.013620631,
0.00742202,
0.0021443658,
-0.02029501,
0.0018504076,
-0.029334651,
0.011133031,
-0.00006239178,
-0.021382486,
-0.011241778,
0.0025963478,
-0.01855505,
-0.012505968,
-0.012200116,
0.013097283,
-0.013484696,
-0.02908997,
0.0021307722,
0.02707814,
0.0075647514,
0.005780612,
-0.0032420363,
0.010901942,
0.0400191,
-0.0042581465,
-0.030802744,
-0.005039769,
-0.020716408,
0.0002527531,
0.02009111,
0.021504829,
-0.0039998707,
-0.018106468,
0.003259028,
0.010106726,
-0.011133031,
0.020865936,
0.0059369365,
0.0054373774,
0.019357065,
0.032678638,
0.024359452,
-0.0099775875,
-0.02344869,
-0.010371798,
-0.012302067,
-0.008135676,
0.0026965993,
-0.0041460004,
-0.00939307,
0.0020950895,
0.018147247,
-0.034663282,
-0.027717032,
0.006854494,
-0.0034748241,
-0.015414965,
0.027785,
0.026792677,
0.016747123,
0.011982621,
-0.0043566986,
-0.0069428515,
-0.0059607252,
0.0010730325,
-0.0006533349,
0.0020730002,
-0.010691243,
-0.007741466,
0.027812187,
0.027322821,
-0.012703073,
-0.005202891,
-0.015088723,
0.00825122,
0.00595053,
0.00236356,
-0.030422127,
-0.03765384,
0.0063685286,
0.00742202,
0.0128933815,
-0.0024043403,
-0.03564201,
-0.014395457,
0.014939195,
0.012404017,
-0.0052062892,
-0.022619491,
-0.022836985,
0.016978212,
0.016760716,
0.012560342,
0.028029682,
-0.010161099,
-0.005009184,
0.004801884,
-0.008760975,
-0.010786397,
-0.0065486417,
-0.030204631,
0.006354935,
0.026507216,
-0.005420386,
0.025392553,
-0.028546233,
0.016964618,
0.016869463,
0.0074492074,
0.01484404,
-0.018255996,
-0.009345492,
-0.016991805,
0.007653109,
0.012879788,
0.023027293,
-0.013158454,
-0.034663282,
0.0090056565,
0.028328737,
-0.0072996793,
-0.011649582,
0.009794076,
0.001144398,
-0.019166756,
0.010385391,
-0.009855247,
0.015115909,
-0.00899886,
-0.010534919,
0.028192803,
0.034527346,
0.02739079,
0.014191556,
0.019520186,
0.008312391,
0.017671477,
-0.0098416535,
0.03485359,
0.008312391,
-0.026480028,
-0.0013109178,
-0.025161464,
0.016978212,
0.0042411545,
-0.025039123,
0.024400232,
-0.0042173658,
-0.005301443,
0.01351868,
0.008570666,
-0.009603768,
-0.011078657,
-0.0022616093,
-0.020906717,
-0.020145483,
-0.031482417,
-0.036104187,
0.0017671477,
0.009121201,
-0.022551524,
0.023231195,
-0.0025300798,
-0.0060388874,
0.02917153,
0.011479664,
0.035859507,
-0.00943385,
0.027105328,
0.015999483,
-0.00038805034,
-0.02009111,
0.0025674617,
-0.005264061,
-0.012206913,
0.01065726,
0.017630696,
-0.019832835,
-0.025569268,
0.03161835,
0.0094746305,
-0.038496632,
-0.027241262,
0.029851202,
-0.013212827,
0.0013856817,
-0.0043566986,
0.005834986,
-0.017807411,
0.035506077,
-0.024169143,
0.016352912,
-0.004526617,
-0.020417353,
-0.022687458,
-0.000023284083,
-0.003493515,
0.017712258,
0.01965612,
-0.03485359,
0.003201256,
-0.012329253,
-0.0005275955,
-0.018120062,
0.0025929494,
0.044233065,
0.026384875,
0.0029038994,
0.0051281266,
-0.005529133,
-0.0060796677,
0.0066166087,
-0.0062461873,
0.038931623,
-0.01109225,
-0.000415662,
-0.019737681,
0.018922074,
-0.003107801,
0.012567139,
-0.020947497,
-0.013450713,
-0.012302067,
0.0020271223,
0.030721184,
0.017304454,
-0.012743854,
0.009814466,
-0.012845805,
-0.015822768,
-0.042058114,
-0.031047426,
-0.009930011,
-0.06008302,
-0.017318048,
-0.0059641236,
-0.0027662658,
0.042139675,
0.009386273,
-0.0057262382,
0.0011172112,
0.023516659,
-0.02289136,
0.005834986,
-0.009134795,
0.0074899876,
-0.030367754,
-0.01625776,
-0.017018992,
-0.03757228,
0.013756565,
-0.0099436045,
-0.004601381,
-0.035560448,
-0.012451595,
0.023353536,
0.02656159,
-0.029307464,
0.04945295,
-0.021572795,
-0.0068273074,
0.01028344,
-0.024998343,
0.020689221,
0.0028223388,
0.003418751,
0.0071501513,
0.0018945863,
0.0032828166,
0.009882433,
-0.016407287,
-0.0067865266,
-0.02794812,
-0.024835221,
-0.015047942,
0.012322457,
0.0023856494,
-0.007890994,
-0.0004179984,
0.015319811,
0.0021953413,
-0.000783747,
-0.004207171,
-0.015958702,
-0.0001909454,
0.019465812,
-0.022524336,
0.0024145355,
-0.0022378208,
0.0062088054,
0.01606745,
-0.02000955,
-0.015863549,
-0.02092031,
-0.04069877,
0.016013077,
-0.005607296,
-0.017821005,
-0.024114769,
-0.01938425,
-0.044749618,
-0.0037721808,
0.01440905,
0.01890848,
0.000042426414,
-0.016516034,
0.009603768,
0.010208677,
-0.021205772,
0.013593444,
-0.010589293,
0.011146624,
0.0045538037,
-0.010086335,
0.020702815,
-0.005216484,
-0.032461144,
-0.013641021,
0.018582238,
0.014640139,
-0.02328557,
0.0066777794,
-0.01642088,
0.00056922546,
-0.0053898003,
0.0064806743,
-0.021858258,
-0.007041404,
0.024780849,
-0.018405523,
-0.03572357,
-0.004383886,
0.0076191253,
-0.019560967,
-0.009542597,
0.016203385,
0.017059771,
0.028736541,
-0.010086335,
-0.042601854,
-0.006776332,
-0.0032216462,
-0.0011579915,
0.02730923,
0.008264814,
0.0130632995,
0.020865936,
-0.006636999,
-0.016719935,
-0.0076599056,
-0.026819864,
-0.0027985503,
0.014599359,
0.0059165466,
-0.006664186,
-0.007313273,
0.017114146,
-0.008883315,
0.017154926,
0.01071843,
-0.024441011,
-0.033385497,
0.026153786,
0.03232521,
-0.021464048,
-0.013627428,
0.011309746,
-0.0038095627,
-0.015809175,
-0.006667584,
0.021219365,
-0.0058995546,
0.018772546,
-0.0027033961,
-0.008815348,
0.0060320906,
0.010997096,
0.009984384,
-0.033140816,
-0.013206031,
0.1637738,
-0.00048256727,
0.00615783,
0.030231819,
-0.007823027,
0.005933538,
0.01567324,
-0.0039590904,
-0.01345751,
-0.008054116,
0.017753039,
-0.009549394,
0.02442742,
0.011065063,
-0.008842535,
-0.005264061,
-0.013858516,
-0.014218742,
-0.018813327,
-0.014463425,
0.0064432924,
-0.029579334,
-0.015115909,
0.0011766825,
0.02154561,
-0.0014978276,
-0.04594584,
0.0006269976,
0.012166132,
-0.008679414,
-0.018106468,
-0.02170873,
0.0013984255,
0.008264814,
0.00019593675,
0.0016482051,
0.012655497,
-0.0036362463,
0.008849332,
0.022864172,
-0.025514895,
0.018650206,
-0.01519747,
-0.016991805,
-0.029144343,
0.0019727484,
0.012546749,
-0.006470479,
-0.017508356,
0.009189168,
-0.037762586,
0.010174693,
0.00257086,
-0.008781365,
-0.018120062,
-0.009963994,
0.03295051,
0.014449831,
-0.011167014,
0.031781472,
0.0011401501,
0.04613615,
-0.024060396,
0.01756273,
-0.022782613,
0.017114146,
-0.00008575551,
-0.0003576775,
0.007823027,
-0.049643256,
0.014177962,
-0.011799109,
-0.004027058,
0.021083431,
-0.008781365,
-0.007415224,
0.009066827,
0.010215473,
0.02316323,
0.025365366,
-0.008788162,
-0.0049955905,
-0.024332264,
0.008543479,
-0.0047712987,
-0.037626654,
0.022347622,
-0.0056276857,
-0.003099305,
-0.013797346,
0.012132148,
-0.028736541,
-0.022388402,
0.011568021,
-0.0032709225,
0.010099929,
-0.010704837,
-0.013172047,
0.006796722,
-0.026398469,
-0.013192438,
0.054727204,
0.024087582,
-0.0031910609,
-0.011364119,
0.007116168,
0.0038333512,
-0.017630696,
0.04306403,
-0.03414673,
-0.0056446777,
-0.0026201364,
-0.0076055317,
0.0019914396,
0.0036226527,
0.019003635,
0.014789667,
0.0042581465,
0.03414673,
0.014055621,
0.014544985,
-0.028981222,
-0.019343471,
0.012410814,
0.0018096272,
-0.020430947,
-0.025623642,
0.0041086185,
-0.00825122,
-0.025881916,
-0.0030619232,
0.0017688469,
0.0016482051,
0.007884198,
-0.0011452476,
0.0033915644,
0.00010768556,
-0.025637235,
-0.04464087,
0.001022057,
-0.016516034,
0.0022904952,
0.041976556,
0.0083667645,
-0.009073623,
-0.02214372,
0.01590433,
-0.003578474,
0.005770417,
-0.0048324694,
-0.011785516,
-0.02968808,
-0.013382746,
0.00078841974,
0.011330135,
-0.011534037,
-0.010827178,
-0.028682167,
0.023829307,
-0.0030857117,
-0.04314559,
-0.011751533,
0.026480028,
-0.037871335,
-0.000011263708,
0.0022921944,
-0.17345235,
0.014273116,
0.013070096,
-0.038578194,
0.027050953,
0.016706342,
0.01069804,
0.015917923,
-0.013627428,
0.02005033,
0.031482417,
0.025718795,
-0.022347622,
-0.01642088,
0.008910502,
-0.023611812,
-0.013960467,
0.01839193,
0.037001353,
-0.008788162,
0.017318048,
-0.012682683,
0.013729379,
-0.029225904,
0.0015335104,
0.03031338,
-0.01107186,
-0.008862926,
0.010256253,
-0.00812888,
-0.019941581,
-0.0027067945,
0.0034782225,
-0.030177446,
0.021097025,
-0.003792571,
-0.004322715,
-0.01760351,
0.011581615,
0.016951025,
0.010154302,
0.014816854,
0.019207535,
-0.029361838,
-0.024740068,
0.049425762,
0.00016832507,
-0.029361838,
0.0045707957,
-0.021232959,
0.0030636224,
-0.0053252317,
0.030585248,
0.03479922,
0.02392446,
0.00528785,
-0.0043634954,
0.015754802,
0.014816854,
0.0009133095,
-0.030231819,
0.007102574,
-0.0049004364,
-0.026452841,
-0.005372809,
-0.03295051,
-0.015319811,
-0.003087411,
-0.016189791,
0.015877143,
-0.009950401,
0.004805282,
-0.0059437333,
-0.014612952,
-0.00093369966,
-0.0004528316,
-0.015047942,
0.019982362,
-0.010494139,
0.0012947755,
-0.023951648,
0.028111242,
-0.018487083,
0.0064840727,
0.011982621,
0.0034153527,
0.009590175,
0.026534403,
0.011017486,
0.0012344546,
-0.0015309616,
-0.012662293,
0.0030194437,
-0.029035596,
0.018351149,
0.035750758,
0.013511883,
0.0037415954,
0.0050669564,
-0.015292624,
0.006664186,
-0.014640139,
-0.02616738,
0.03588669,
0.022687458,
0.0002710193,
-0.01729086,
0.017753039,
0.029497772,
0.0036124578,
-0.016475255,
-0.017059771,
0.018065687,
0.0076123285,
0.0002544523,
0.011479664,
-0.022034973,
-0.0028750133,
0.016584001,
-0.022130126,
0.04219405,
0.012580732,
-0.011289355,
0.015537307,
0.006062676,
-0.023204008,
-0.09531723,
-0.0063685286,
-0.009542597,
-0.007435614,
-0.03189022,
0.018133653,
-0.0011095649,
0.02005033,
-0.016638376,
0.007061794,
-0.02206216,
-0.032624267,
-0.0066879746,
-0.014803261,
0.018255996,
0.009630955,
-0.00039760824,
0.01594511,
-0.022238875,
0.03583232,
-0.008237627,
-0.013206031,
0.00011108392,
-0.0029327855,
0.011017486,
0.00371101,
-0.012363237,
0.009338696,
0.0038911232,
0.022904953,
0.007258899,
-0.010099929,
0.012981739,
-0.004190179,
-0.024237111,
0.028899662,
-0.015265438,
-0.018500676,
0.013280795,
-0.021450454,
0.0056412793,
-0.008536682,
0.005264061,
-0.012077775,
0.023095261,
-0.015075129,
-0.017154926,
0.017059771,
0.017508356,
-0.026439248,
0.007095778,
-0.009712515,
-0.018106468,
-0.0163801,
0.0015199169,
-0.036756672,
0.013511883,
0.03713729,
-0.005600499,
0.014422644,
0.014748886,
-0.0014128686,
-0.00034387165,
0.0041561956,
0.026113005,
-0.020947497,
0.020104704,
-0.026860645,
0.037082914,
-0.038224764,
0.010086335,
-0.020376572,
-0.0055869054,
-0.0015122707,
-0.0064738775,
0.0035886692,
-0.03667511,
0.0025878518,
0.002691502,
-0.0119554335,
0.0007179038,
-0.011833093,
0.016108232,
0.017739445,
-0.0031010043,
0.023774933,
-0.011656378,
0.0027050953,
0.0063753254,
-0.019955175,
0.0019506592,
0.023095261,
-0.017739445,
-0.039121933,
-0.014735294,
0.01190106,
0.012288474,
-0.0007145054,
0.0071841353,
0.00034174768,
-0.015265438,
-0.013287592,
-0.076395154,
0.028600605,
0.00306872,
0.006650592,
-0.012132148,
-0.0005586056,
0.016719935,
0.0032488331,
-0.014177962,
0.006823909,
-0.011724345,
0.0038809283,
-0.032379583,
-0.020430947,
-0.018188028,
-0.009930011,
0.03702854,
-0.009012453,
0.018527864,
0.028192803,
-0.002796851,
0.010235863,
0.017263673,
0.030095885,
-0.013878906,
-0.014055621,
0.0059539285,
0.03265145,
-0.024359452,
-0.013681801,
-0.008020132,
-0.01233605,
0.01977846,
0.028247176,
0.008359968,
0.020634849,
-0.006402512,
0.008101692,
-0.00043966295,
0.04692457,
-0.027785,
-0.028383112,
0.026901426,
-0.019669713,
-0.013627428,
-0.0040304563,
-0.030993052,
-0.004050846,
0.007646312,
-0.005811197,
0.028084055,
0.013396339,
-0.0067015677,
-0.012839008,
0.002061106,
-0.025351772,
0.013708988,
-0.01756273,
-0.020471726,
-0.027132515,
0.028219989,
0.022483556,
0.02206216,
0.017630696,
-0.0012217108,
-0.004944615,
-0.014150775,
0.003680425,
0.0036498397,
-0.043118402,
-0.014273116,
-0.0006868937,
0.0084347315,
0.009114404,
-0.001459596,
0.014232336,
-0.026384875,
0.02581395,
-0.01654322,
0.01606745,
0.0076870923,
-0.025039123,
-0.009161981,
0.005872368,
0.024169143,
0.0032301422,
-0.010969909,
0.015646053,
-0.005661669,
0.0077618565,
-0.02044454,
0.013715785,
0.012104962,
0.007992945,
-0.029633708,
0.040861893,
0.020852342,
0.0052402727,
0.027282042,
0.021899039,
0.005563117,
0.007952165,
-0.007523971,
-0.02340791,
-0.005998107,
0.014245929,
-0.017277267,
-0.038306326,
-0.0012743854,
0.0012590927,
0.0071909316,
0.009562988,
0.015469339,
0.01650244,
-0.015958702,
-0.009896027,
-0.0053388253,
-0.0048698513,
-0.016787903,
0.016284946,
0.0023414707,
0.025338179,
0.03229802,
-0.004003269,
-0.021246552,
0.019221129,
0.051247284,
-0.03746353,
-0.0019625535,
-0.023870088,
0.009617361,
0.0023074872,
-0.021532016,
-0.004805282,
-0.012587529,
0.014205148,
0.017888973,
0.026466435,
-0.007258899,
0.06671663,
0.0098416535,
-0.0065690316,
-0.0032488331,
-0.029742455,
0.010956315,
0.014123588,
0.001986342,
0.011282559,
-0.021899039,
-0.017671477,
-0.017494762,
0.0041460004,
-0.031563975,
-0.051954143,
0.0138313295,
0.0021409674,
0.012696276,
-0.005631084,
-0.013178844,
0.030204631,
-0.007326866,
0.04988794,
0.030503688,
-0.021097025,
-0.0037551888,
0.00825122,
-0.001322812,
-0.0099436045,
-0.050268557,
0.0009218054,
0.0029072978,
-0.045266166,
0.0034221495,
0.03327675,
-0.0088697225,
-0.008142473,
-0.0043533,
0.027186887,
0.017236486,
0.014150775,
0.004805282,
-0.017032586,
-0.012832211,
0.021178586,
-0.0017170219,
-0.0077550597,
-0.02139608,
-0.008108489
] |
We investigated the capacity of young ovaries, transplanted into old ovariectomized CBA mice, to improve remaining life expectancy of the hosts. Donor females were sexually mature 2-month-olds; recipients were prepubertally ovariectomized at 3 weeks and received transplants at 5, 8 or 11 months of age. Relative to ovariectomized control females, life expectancy at 11 months was increased by 60% in 11-month recipient females and by 40% relative to intact control females. Only 20% of the 11-month transplant females died in the | [
-0.022798216,
-0.038939025,
0.002095724,
-0.01696959,
-0.021276524,
-0.00032565242,
-0.023871552,
-0.0036479863,
-0.043585625,
-0.015148994,
0.014578358,
0.011045858,
0.007255213,
-0.0061241332,
-0.0052070417,
0.017771196,
0.02639865,
0.009333954,
0.0016380274,
-0.014768571,
-0.012723796,
0.0020159031,
-0.03005343,
0.007941334,
0.0027308948,
-0.0009688902,
0.007255213,
-0.026058987,
0.034346778,
-0.0063585015,
0.00018002167,
0.016779378,
-0.042063933,
-0.017988581,
-0.03358593,
-0.021752052,
0.0049488978,
-0.02203737,
0.015013128,
0.0151354065,
0.026779072,
0.0032760547,
-0.0011149455,
0.03586847,
0.00019785401,
0.022947667,
-0.035053276,
-0.04043355,
-0.0055908617,
0.003469663,
-0.014360974,
0.014048483,
-0.01626309,
0.023178639,
-0.0208961,
0.0055093425,
-0.011996916,
0.02552911,
0.0077986745,
-0.0008062763,
-0.0012593025,
0.0007009806,
-0.02934693,
0.014048483,
-0.022377033,
0.03051537,
-0.014034897,
0.0021568635,
0.00471453,
-0.00836931,
0.037607547,
0.013484642,
-0.013015906,
-0.0054074433,
0.021847159,
0.0065215398,
-0.02926541,
0.026493756,
0.011018685,
0.0018104066,
0.02820566,
-0.03366745,
-0.015773974,
0.020379812,
0.011025478,
0.01156894,
0.00041099289,
0.006473987,
0.014673465,
0.0027835427,
0.028314352,
0.018898878,
0.015230512,
0.03421091,
-0.0003793617,
0.01337595,
0.0039367005,
0.036248893,
-0.011874637,
-0.030977314,
-0.0143473875,
0.0077511217,
0.00008189076,
-0.02243138,
-0.03084145,
-0.0014240394,
0.00052350643,
-0.009476612,
0.028178487,
-0.005502549,
-0.010400497,
0.05255274,
0.006297362,
-0.012683036,
-0.004035203,
0.0017085075,
-0.007846228,
-0.009483405,
-0.02529814,
0.004510732,
0.027879583,
-0.010699402,
0.02855891,
-0.013144978,
-0.004388453,
0.0069902753,
-0.013885445,
0.013593335,
-0.013511815,
-0.0019055124,
-0.0011404203,
-0.006857807,
0.015312032,
0.028178487,
-0.024292735,
0.015026715,
-0.04195524,
-0.0052138353,
-0.0016872786,
-0.041438952,
0.0046364074,
0.029999083,
0.000112301255,
0.00024519462,
-0.023939485,
0.011555353,
0.024890544,
0.0060494076,
0.0055840686,
0.028287178,
-0.0115961125,
-0.0009867225,
0.022771044,
-0.025624217,
0.028015448,
0.002090629,
0.008593488,
0.021534668,
-0.017458705,
0.0073503186,
0.00020485956,
0.010054041,
0.015706042,
0.014510426,
-0.000053948123,
0.011202103,
0.0052206283,
0.021738466,
0.0076628095,
0.0005753051,
-0.014700637,
0.008899185,
-0.023355264,
0.039265104,
0.01084206,
0.015040301,
-0.01834183,
-0.0071736937,
-0.032553352,
-0.020162428,
-0.016915243,
0.0042797606,
-0.0057199337,
0.03570543,
-0.03673801,
-0.0028209055,
-0.015746802,
-0.014863676,
0.01582832,
-0.008634247,
-0.0070989677,
0.032308795,
0.010556743,
0.0071465205,
-0.6378066,
-0.01653482,
0.010692608,
-0.008518761,
0.016113637,
0.028423045,
-0.003518914,
-0.0048571886,
-0.031493604,
0.014945195,
-0.006171686,
0.014918022,
0.01838259,
0.0012100514,
0.0032590716,
-0.021222178,
0.014836503,
0.0104140835,
0.021507494,
0.011249656,
0.012941181,
-0.010923579,
0.0040827557,
0.032770738,
0.0322001,
0.008423655,
0.03051537,
-0.02455088,
-0.0059746816,
0.015692456,
0.016235916,
0.04638445,
-0.015773974,
-0.0036581762,
0.0509767,
-0.015665282,
-0.01661634,
0.0051425057,
-0.008804079,
0.050813664,
-0.017146215,
-0.009571718,
0.0084508285,
0.0068781865,
-0.03005343,
-0.0011633476,
0.008600281,
-0.007234833,
-0.009150536,
-0.00035006573,
0.019863524,
0.010787713,
-0.00650116,
-0.024224803,
-0.023396024,
0.0022061146,
0.039998777,
0.004918328,
0.015393551,
-0.023626994,
0.004853792,
0.008199478,
0.005682571,
-0.008247031,
-0.034863066,
0.011718391,
-0.010774127,
0.031357735,
0.028423045,
-0.016371783,
0.019265715,
0.01983635,
-0.016820138,
-0.01971407,
0.013538988,
0.03271639,
-0.0080636125,
0.0023300918,
-0.015964186,
0.01406207,
0.005128919,
-0.00092303567,
0.011385522,
0.011888224,
0.028939333,
-0.0130430795,
-0.017730435,
0.015923426,
-0.013117805,
0.011772738,
0.013097426,
0.011949363,
0.004666977,
-0.023776447,
-0.0026188057,
-0.0015913236,
-0.005084763,
0.01547507,
0.009442646,
-0.029482795,
-0.011718391,
0.007853021,
0.00683403,
0.0009179407,
0.0122550605,
0.014442493,
-0.036085855,
0.005366684,
0.035080448,
-0.03157512,
-0.007819055,
0.013858272,
0.0006687126,
-0.0050134338,
-0.013233291,
-0.019727658,
0.009401887,
-0.0021823382,
0.008219858,
-0.032471832,
0.036574967,
0.0057437103,
0.03306964,
-0.019537447,
0.010522776,
0.01779837,
0.007445425,
-0.0006130927,
-0.011161343,
0.0052206283,
0.016276676,
0.008817665,
-0.017431533,
-0.0166571,
0.0208961,
-0.008410069,
0.0042050346,
-0.015692456,
0.013810719,
-0.0080568185,
-0.026928525,
0.024360668,
0.0057674865,
-0.0012075038,
0.0044020396,
-0.006246412,
0.010359738,
0.001475838,
-0.0057301237,
-0.0095037855,
-0.017974993,
-0.01364768,
0.0012185429,
-0.00042457943,
-0.005084763,
-0.015053888,
0.0040963423,
-0.013382743,
-0.015407138,
0.017186975,
-0.0030994297,
0.010251045,
-0.0018511662,
-0.004826619,
-0.011270036,
-0.010876026,
0.012221094,
-0.0028344921,
-0.014863676,
-0.023586236,
-0.0011794816,
-0.030461024,
-0.013328397,
-0.010067627,
-0.020787409,
-0.008226651,
-0.005193455,
-0.012180334,
-0.00035325007,
0.012071642,
-0.008695386,
-0.010251045,
-0.011005098,
0.003310021,
0.030026255,
0.02934693,
-0.0010334263,
-0.0018155016,
-0.0011472136,
0.018939639,
-0.0012270345,
0.031683814,
-0.00068357284,
0.017580984,
-0.0005438862,
-0.042091105,
0.004609234,
0.010631468,
0.023626994,
0.020243946,
0.035977162,
-0.02820566,
0.014741397,
-0.018165205,
0.0061513064,
-0.012289027,
0.0022095114,
-0.0075473236,
0.01266945,
0.010923579,
0.0040759626,
0.0046499935,
-0.007737535,
-0.01881736,
0.000850008,
0.014578358,
-0.0019853334,
-0.006222636,
-0.008613867,
0.005159489,
-0.023273746,
-0.013477849,
0.01728208,
0.0062090494,
-0.009748343,
0.020311879,
0.023178639,
-0.0046703736,
0.010889613,
-0.016833724,
-0.015801147,
0.015094647,
0.0024302925,
0.0047450997,
0.02639865,
0.0040012365,
0.024917716,
-0.00013671457,
0.008566314,
0.023830794,
0.013362363,
0.01078092,
0.01956462,
-0.00687479,
-0.02793393,
-0.013525402,
0.0201896,
0.020406986,
-0.0146191185,
-0.01555659,
0.0033762555,
-0.0038959407,
-0.0008686895,
-0.010264632,
0.004527715,
0.0008330248,
-0.003970667,
0.0017662504,
-0.001973445,
0.036928218,
0.026507342,
0.01154856,
-0.003929907,
-0.014687051,
0.0056655877,
0.020298293,
0.016004946,
0.00687479,
0.022567244,
-0.029238237,
-0.015081061,
-0.006100357,
0.016602753,
-0.017744023,
-0.0039434936,
0.009007877,
0.0041133254,
0.010943959,
0.00037278072,
-0.00539046,
-0.03358593,
-0.016195158,
0.02741764,
0.018586388,
-0.009259228,
-0.002197623,
-0.004721323,
-0.0079753,
0.0024880352,
0.00051628856,
0.022512898,
-0.0053395107,
-0.007160107,
0.01333519,
-0.0026510737,
-0.018314658,
0.024578054,
-0.02340961,
0.0058931625,
-0.013498229,
0.021385215,
-0.000060290276,
-0.0019530653,
-0.01078092,
0.0018732444,
-0.0076288427,
-0.020909688,
-0.044101913,
-0.0065351264,
0.0005948357,
-0.012846075,
-0.023232985,
-0.009157329,
-0.0008576504,
-0.012880041,
-0.0005349701,
-0.01661634,
0.0043409,
0.035759777,
0.0077171554,
-0.006073184,
-0.0048198253,
-0.022906909,
-0.026806246,
0.044998623,
-0.0041710683,
0.01115455,
0.023069946,
0.013287637,
-0.019157022,
0.0039842534,
-0.004989657,
0.037172776,
0.025637804,
0.0012703416,
0.0093747135,
0.029673006,
-0.0038042315,
0.0022961255,
0.0056282245,
-0.0020447744,
-0.039618354,
-0.0126422765,
-0.01229582,
0.0020804391,
0.0039434936,
0.024645986,
0.045433395,
0.028096966,
-0.0054244264,
0.026643207,
0.022988427,
0.012567551,
0.010237459,
0.0028684584,
0.008559521,
0.0005549253,
0.021195004,
0.010278218,
-0.0038823541,
0.019985802,
0.00042649,
0.009992901,
0.03287943,
0.011772738,
0.027173083,
0.014850089,
0.0009952141,
0.036439102,
-0.03562391,
0.00086232077,
0.006018838,
-0.016684273,
-0.009748343,
0.05007999,
0.01802934,
-0.030732756,
-0.00039252365,
-0.009177709,
0.037498854,
-0.018056514,
-0.01406207,
0.0015930219,
0.010787713,
0.007255213,
-0.037199948,
0.00031376418,
-0.0016813345,
0.00905543,
-0.011018685,
-0.027091563,
0.0019275906,
-0.010291805,
-0.01763533,
-0.03244466,
0.010889613,
-0.0056859674,
0.0055738785,
0.018369004,
0.023165053,
0.0130430795,
-0.010244252,
-0.010617882,
0.012078435,
-0.007153314,
-0.02918389,
-0.010223872,
-0.008505175,
0.024917716,
-0.0011896715,
-0.009958935,
-0.019795591,
-0.038775988,
-0.008158718,
0.025189448,
-0.0042254142,
-0.001961557,
-0.015176167,
-0.007703569,
-0.014320214,
0.0035834503,
0.025393246,
0.0076628095,
-0.020828167,
0.013878652,
-0.0005116182,
-0.012458858,
-0.034428295,
-0.043558452,
0.021113485,
-0.017119043,
0.015407138,
-0.0232194,
-0.012458858,
0.013593335,
-0.010271425,
0.01779837,
0.003790645,
0.007853021,
0.02014884,
0.00468396,
0.019646138,
0.028151313,
0.019700484,
0.00614791,
-0.020991206,
0.025162274,
-0.001304308,
-0.007757915,
0.0009179407,
-0.013600128,
-0.0033728587,
-0.035107624,
0.020053735,
0.02839587,
0.020053735,
-0.005488963,
-0.055405915,
-0.015733214,
-0.019768417,
-0.0059644915,
0.026738314,
0.0072687995,
-0.003902734,
-0.015026715,
0.0031826473,
-0.014931609,
-0.03464568,
0.024659572,
-0.026344303,
-0.018097272,
0.007323146,
0.0066981646,
0.0057029505,
-0.0023827397,
0.0032471833,
-0.018015753,
-0.007574497,
-0.014265868,
-0.024578054,
0.023124292,
-0.022227582,
0.01854563,
0.027784476,
0.026249198,
-0.0026442807,
0.010332565,
0.038422737,
0.015692456,
0.0021042156,
0.020406986,
0.029374102,
0.010359738,
0.01763533,
-0.0028786485,
0.02305636,
-0.026602447,
-0.015026715,
0.012112401,
0.0347272,
-0.030433852,
-0.0059950612,
-0.014225109,
-0.034129392,
-0.01881736,
-0.01227544,
0.019469513,
0.0073027657,
-0.01763533,
-0.0006271038,
0.012818902,
0.023151467,
0.015855493,
-0.016548406,
0.0244286,
-0.02266235,
-0.0014376258,
0.0044937483,
-0.025760083,
0.020909688,
-0.009442646,
-0.0020940257,
0.0011786325,
-0.0039910465,
0.004116722,
0.008280997,
0.008444035,
-0.003501931,
0.009891002,
0.00014064193,
-0.026942112,
0.0051492993,
-0.002250271,
-0.017499465,
0.0076356363,
-0.008702179,
-0.028042622,
-0.020678716,
-0.01123607,
0.012737382,
-0.010203493,
0.042172626,
-0.010515983,
-0.009571718,
-0.0021466736,
-0.021439562,
0.036194544,
-0.03546087,
0.019061917,
0.022132475,
0.0031962339,
-0.0069053597,
-0.032825083,
0.019741245,
0.026385063,
0.01767609,
0.0492648,
-0.02561063,
-0.012411306,
0.018233139,
0.01696959,
-0.029564314,
-0.04426495,
0.03024364,
0.004184655,
-0.0072144535,
-0.0014783855,
-0.020420572,
-0.021874331,
0.006436624,
-0.03051537,
-0.009449439,
0.018192379,
0.01944234,
-0.00171615,
0.009612478,
-0.0032573733,
-0.004836809,
0.002218003,
-0.0067457175,
-0.007968507,
-0.034808718,
-0.014360974,
0.012153161,
-0.0027920343,
0.034428295,
0.002197623,
0.0032437867,
-0.013138185,
-0.016561994,
-0.015053888,
-0.026738314,
-0.012975147,
0.03524349,
0.00720766,
-0.0061445134,
-0.006259999,
0.02997191,
-0.016195158,
-0.011344762,
-0.01516258,
-0.01040729,
-0.02357265,
-0.016317436,
0.015977772,
0.020787409,
-0.016249504,
-0.023246571,
-0.035026103,
0.015896253,
-0.027906755,
-0.011643666,
-0.0040385993,
-0.021317283,
0.0015836812,
0.017105455,
0.0012983638,
0.017608158,
-0.0048232223,
-0.030732756,
0.021833573,
0.029999083,
-0.019428754,
0.010896406,
0.021507494,
-0.0025916328,
-0.033287026,
0.004972674,
-0.022404207,
0.0036276064,
0.005111936,
-0.014211522,
-0.027743718,
-0.0026205042,
-0.005319131,
0.015352791,
-0.005064383,
-0.0061852727,
0.021154245,
-0.0029788492,
0.014918022,
-0.027825236,
-0.02855891,
0.014225109,
-0.00089246593,
-0.017350012,
-0.0038178181,
-0.01622233,
0.0045854575,
-0.0057708835,
0.0146191185,
0.024088938,
-0.01779837,
0.013212911,
0.0033253059,
-0.0010325771,
-0.008301376,
-0.021031966,
-0.025787255,
-0.02945562,
-0.028096966,
0.024442188,
-0.0045854575,
-0.010563536,
-0.017350012,
0.028857814,
0.011073031,
0.00645021,
0.007771502,
0.022866149,
0.006939326,
-0.01701035,
-0.016521234,
0.0030705584,
-0.024415014,
0.025148688,
0.018015753,
-0.017621744,
-0.022173235,
-0.017947821,
-0.01771685,
-0.018301072,
0.008301376,
0.020488504,
0.0006109698,
0.015624522,
0.030868622,
0.003298133,
-0.01406207,
0.01896681,
-0.048449606,
-0.009238848,
0.016494062,
-0.014483253,
0.023246571,
0.009089396,
-0.04823222,
-0.02600464,
0.0029856425,
0.003501931,
-0.0010071023,
0.006008648,
0.008647833,
0.003828008,
-0.024184043,
-0.0031588709,
0.010352944,
0.0037498854,
-0.008484795,
-0.04127591,
0.004116722,
0.016344609,
-0.007526944,
-0.0019870317,
-0.03393918,
-0.023083534,
-0.0019717468,
-0.0015480166,
-0.018532041,
0.006704958,
0.01163008,
-0.012594724,
0.01011518,
0.027349707,
0.0044190227,
0.007085381,
0.019782005,
-0.00047213232,
-0.017621744,
0.012601517,
-0.007506564,
-0.0026850402,
-0.0030247038,
-0.004806239,
0.014048483,
-0.01673862,
0.0027393864,
-0.021955851,
-0.000019663334,
0.004198241,
-0.017662503,
-0.017608158,
0.019849937,
0.018790187,
0.002951676,
-0.009293194,
0.02718667,
-0.006484177,
-0.008600281,
-0.014564772,
-0.022336274,
-0.0034594731,
-0.023477543,
0.011140964,
-0.0031079212,
-0.017091868,
0.0058727823,
0.0028073192,
0.0019479704,
0.02234986,
0.18347265,
-0.0073978715,
0.000973136,
0.015678868,
0.0068646,
-0.014537599,
0.041140046,
-0.000013201766,
0.0020515677,
0.021480322,
-0.003481551,
0.001732284,
-0.008138338,
-0.00045472456,
0.016167983,
-0.022716697,
-0.009089396,
-0.009748343,
-0.015379964,
0.0033320992,
-0.008654627,
-0.008729353,
0.0075405305,
0.0023555665,
0.02883064,
0.010509189,
-0.023722101,
0.0013645983,
0.005268181,
0.0092456415,
-0.002010808,
-0.014795743,
0.013464263,
0.0040080296,
0.0057776766,
-0.018287484,
-0.004476765,
-0.030624064,
-0.0027122132,
-0.015461484,
-0.0047824625,
0.049563702,
0.013158565,
0.012431685,
-0.019632552,
0.04187372,
0.0045480947,
-0.017974993,
-0.031874027,
-0.01881736,
-0.027132323,
0.005224025,
0.0071736937,
0.015583763,
0.004806239,
-0.0060799774,
0.030189294,
-0.00826741,
0.0012873248,
0.015298446,
-0.023015602,
0.005040607,
-0.028260006,
0.015094647,
-0.0056859674,
0.039971605,
-0.0040250127,
-0.00076636585,
0.00091709156,
0.014687051,
-0.0050338134,
-0.0057301237,
-0.029836044,
-0.002309712,
-0.00095954945,
-0.012703416,
0.02353189,
0.031412084,
0.0013679948,
0.0043273135,
-0.0073367325,
-0.0047179265,
0.0010308789,
0.014646292,
-0.030651238,
-0.025189448,
0.02793393,
0.014388147,
-0.006779684,
-0.0009884209,
0.0076424293,
-0.011582526,
0.00758129,
-0.02474109,
0.009381507,
0.004534508,
0.016765792,
0.04459103,
-0.013178945,
0.0146191185,
-0.015923426,
0.044998623,
0.019904282,
-0.008043232,
-0.00070819847,
0.0024438791,
-0.016779378,
0.046574663,
-0.007880194,
-0.03377614,
0.006181876,
-0.0104140835,
-0.00016261391,
0.0043510897,
0.004982864,
0.015379964,
-0.009211675,
-0.028721947,
0.0063822777,
0.0035358972,
-0.012112401,
-0.048177876,
0.007859814,
0.023925899,
-0.015937014,
-0.048259396,
-0.04065093,
-0.0020125064,
-0.032553352,
-0.010536362,
0.00057657884,
-0.017132629,
-0.014007724,
0.0030060222,
0.025094341,
-0.016901657,
-0.00037278072,
-0.009571718,
-0.026167678,
0.012193921,
-0.0027037216,
-0.017934235,
0.009463026,
0.005363287,
0.01489085,
-0.027879583,
0.00033860208,
-0.0064604003,
-0.007119348,
-0.006090167,
-0.044400815,
-0.020447744,
-0.0017305857,
-0.010196699,
0.015841907,
-0.013905825,
-0.032988124,
-0.05668305,
0.0025253983,
0.011867844,
-0.021697706,
0.009734756,
0.0034883444,
0.010515983,
-0.0054074433,
-0.010271425,
-0.17260341,
0.013341984,
0.021534668,
-0.031221872,
0.004058979,
-0.027077977,
0.012261854,
-0.008009266,
-0.00066319306,
-0.015502243,
0.01329443,
0.035977162,
-0.01578756,
-0.015094647,
0.01834183,
-0.00053921586,
-0.0173636,
0.01582832,
0.049509358,
0.000537093,
0.014048483,
-0.0059475084,
0.022444965,
-0.025203034,
-0.0030382902,
0.002683342,
0.014320214,
-0.01661634,
0.012159955,
-0.045596432,
-0.045868162,
0.020325465,
0.0038823541,
-0.0040929457,
-0.0053429073,
-0.006956309,
-0.015801147,
-0.01696959,
0.013226498,
0.023205813,
0.0072959727,
0.016371783,
-0.019686898,
0.0152712725,
-0.020733062,
0.0319012,
0.0035257074,
0.0008865218,
0.008145131,
-0.016561994,
0.009823069,
-0.00006220088,
0.020515677,
0.005319131,
0.008912771,
-0.00096039864,
0.019265715,
0.019768417,
0.0159506,
0.0087089725,
-0.003726109,
-0.0036208131,
0.035678256,
-0.005162886,
-0.014211522,
-0.030379506,
-0.03339572,
0.014551186,
-0.016561994,
-0.003780455,
-0.018450523,
0.0034849478,
0.028613256,
-0.00254408,
0.03858578,
0.009626064,
0.0065622996,
-0.021779226,
0.027988276,
0.019537447,
-0.0080636125,
0.009496992,
-0.038015142,
-0.007771502,
-0.011494214,
0.007846228,
0.02172488,
0.016371783,
-0.001876641,
-0.006789874,
-0.0069698957,
-0.03393918,
-0.0208961,
-0.024781851,
0.007526944,
0.031140352,
0.0068883765,
-0.016072879,
0.018599974,
-0.019157022,
0.01266945,
-0.024537293,
-0.011249656,
-0.015855493,
0.023735687,
-0.022173235,
-0.013362363,
-0.012805315,
0.025420418,
-0.0070989677,
0.009911382,
0.0038755608,
0.008702179,
0.003330401,
0.0035257074,
0.027879583,
0.009999694,
0.004442799,
0.028531736,
-0.0232194,
0.046683356,
0.016371783,
-0.0047926526,
0.0038619742,
0.012336579,
0.0173636,
-0.123583175,
-0.02455088,
-0.008274203,
0.028803468,
-0.020570023,
0.005366684,
0.016290262,
0.042199798,
-0.019551033,
0.027675785,
-0.0194831,
-0.018491283,
-0.0033270044,
-0.0050813663,
0.048721336,
-0.01590984,
0.010142353,
0.000040520797,
0.003379652,
0.029999083,
-0.003885751,
-0.015176167,
0.013994138,
-0.007357112,
-0.0018868309,
-0.0031249046,
-0.036167372,
0.01759457,
0.0040895487,
0.019985802,
0.023694929,
-0.015216926,
0.012805315,
-0.009571718,
-0.040949836,
-0.007941334,
-0.016820138,
-0.022105303,
0.018926052,
-0.032960948,
-0.016371783,
-0.0001867088,
0.018056514,
0.00068612036,
-0.0010988115,
0.0023657565,
-0.020637956,
0.0024931303,
-0.021670533,
-0.013219705,
-0.03184685,
0.0011208897,
0.0086818,
0.0118610505,
0.021983024,
-0.03393918,
0.021738466,
-0.016901657,
-0.003912924,
-0.015461484,
-0.005298751,
0.006473987,
-0.038558602,
0.008090786,
0.014130003,
-0.022852562,
-0.0068781865,
-0.021004792,
-0.0041404986,
-0.013280844,
-0.008851632,
0.015583763,
0.00649097,
-0.009891002,
-0.027322534,
-0.0023436784,
0.016643513,
-0.011086618,
0.0050609866,
-0.01040729,
0.0011293812,
-0.016480474,
0.025121514,
-0.009496992,
0.0006767796,
0.009544545,
0.022295514,
0.00017428985,
-0.0004598195,
0.003362669,
-0.009415473,
0.0173636,
-0.02164336,
-0.029020851,
-0.015570176,
0.0025169067,
-0.015176167,
-0.01194257,
0.035678256,
0.0034323,
-0.040487893,
-0.010869233,
-0.053666838,
0.019496687,
0.018586388,
-0.025447592,
-0.016792964,
-0.0152712725,
0.023817206,
-0.006293965,
0.010631468,
0.0068612034,
-0.023069946,
0.0014350784,
-0.043694317,
-0.004249191,
-0.006776287,
0.0004538754,
0.009028257,
-0.0064705904,
0.040678103,
0.022567244,
0.017866302,
0.0017628537,
0.019741245,
-0.0012499618,
-0.013899032,
0.017200561,
-0.003753282,
0.0054074433,
0.0039740633,
-0.00032904904,
-0.0043578832,
-0.037743412,
-0.0062192394,
0.015339205,
-0.0024302925,
-0.0060290275,
0.016765792,
0.025393246,
0.024564467,
0.020637956,
-0.01329443,
-0.034863066,
0.016670685,
-0.008219858,
-0.01582832,
-0.0026103142,
-0.009829863,
0.006175083,
-0.00234198,
-0.0022078129,
0.032064237,
-0.0037872484,
0.0166571,
-0.0064604003,
0.005271578,
0.011222483,
-0.01184067,
-0.015053888,
-0.022200407,
-0.001331481,
0.01854563,
0.011249656,
-0.011793118,
-0.012927594,
0.029863218,
-0.03217293,
-0.012445272,
-0.011623286,
0.011541767,
-0.01987711,
-0.020053735,
0.014469666,
0.013450676,
0.011168137,
-0.011473834,
-0.004442799,
-0.010251045,
0.022553658,
-0.013715614,
0.031412084,
0.006310948,
-0.019455926,
-0.015393551,
0.017744023,
-0.0026272973,
0.024184043,
-0.0043918495,
0.025406832,
-0.0039434936,
0.008274203,
-0.004802842,
0.008946737,
0.01156894,
-0.012927594,
0.0025644596,
0.02309712,
-0.0110798245,
-0.008613867,
0.0052002487,
0.0030501785,
0.0019632552,
-0.0030450835,
-0.0063585015,
-0.03146643,
-0.008464416,
-0.0058252295,
-0.029156717,
-0.037852105,
-0.025325313,
0.03369462,
0.023382436,
0.020406986,
0.012567551,
0.013389536,
-0.0068374267,
0.009924969,
-0.007554117,
-0.03834122,
-0.027200256,
0.034455467,
0.0021110089,
0.01917061,
-0.010740161,
-0.010977926,
0.01881736,
-0.025135102,
0.0382597,
-0.025406832,
0.0020974223,
-0.023273746,
0.04317803,
-0.0274584,
-0.026575275,
-0.005336114,
0.023640582,
-0.02368134,
-0.0067966674,
0.007506564,
-0.0012414702,
0.06195463,
0.014197935,
-0.010536362,
0.008620661,
-0.007200867,
0.031710986,
0.007656016,
0.026629621,
-0.002528795,
-0.0297817,
0.01622233,
-0.006704958,
0.028151313,
-0.0038246114,
-0.03853143,
0.026181266,
0.0017407755,
0.00832855,
-0.010196699,
-0.014265868,
0.01767609,
-0.02989039,
0.008600281,
0.015352791,
-0.019143436,
0.0047179265,
0.025950294,
-0.015692456,
0.026860591,
-0.026072573,
0.011344762,
0.020434158,
-0.027567092,
-0.0066913716,
0.0042797606,
-0.009075809,
-0.00980269,
-0.0072416263,
-0.009585305,
0.015706042,
-0.013600128,
-0.00614791,
-0.016507648,
-0.0016193459,
-0.017309254,
-0.016358195,
-0.0044665756,
0.0050983494,
-0.027621439
] |
OBJECTIVE To assess the association between use of macrolide antibiotics in mothers and infants from pregnancy onset until 120 days after birth and infantile hypertrophic pyloric stenosis (IHPS). DESIGN Nationwide register based cohort study. SETTING Denmark, 1996-2011. PARTICIPANTS 999,378 liveborn singletons and linked individual level information on macrolide prescriptions (maternal use during pregnancy, n=30,091; maternal use after birth, n=21,557; use in infants, n=6591), surgery for IHPS, and potential confounders. MAIN OUTCOME MEAS | [
0.013350213,
0.0013456801,
0.018519755,
-0.037918866,
-0.030324435,
0.027606428,
0.0004717375,
0.007114784,
0.0037439219,
-0.0074478732,
0.012877226,
-0.00017830679,
0.0019019389,
0.011731399,
-0.003740591,
0.025474656,
0.034907743,
-0.0009651258,
0.0053127715,
0.0023649328,
-0.023209652,
0.0028728938,
-0.003460796,
-0.0125174895,
0.010012659,
0.0062320977,
0.006008928,
-0.025128245,
-0.016641133,
-0.006558525,
0.0032126447,
-0.003953768,
0.016374663,
-0.0008693627,
-0.022410236,
-0.025527952,
0.012064489,
0.0017620416,
-0.0045799757,
0.0038838193,
0.01565519,
-0.0060255826,
-0.0061488254,
0.013243624,
0.0019385788,
0.009859438,
0.024581978,
0.0029278535,
-0.019332493,
0.003833856,
0.013343551,
-0.01035241,
0.0031760049,
0.015108923,
0.008160684,
-0.0012282662,
-0.0049863444,
0.018826198,
0.0042801956,
-0.031443615,
0.0048897485,
0.008060757,
-0.032083146,
-0.00043676313,
-0.0131503595,
0.0047665057,
-0.029738199,
0.020065289,
-0.0036040244,
0.0050029987,
0.049084015,
0.034348153,
0.008560391,
-0.0076210797,
0.012131106,
-0.020718144,
-0.013476786,
-0.020611556,
0.0091066575,
0.02126441,
0.03194991,
0.0066118194,
-0.003830525,
0.02066485,
-0.000111897134,
-0.010365734,
0.00035765447,
0.045859713,
-0.010658853,
-0.013243624,
0.017800283,
0.02376924,
-0.00026147498,
0.0036073553,
0.017387252,
0.019292522,
-0.011111854,
0.04066352,
-0.013883155,
0.0066984226,
-0.021384323,
0.004929719,
-0.021850647,
-0.010778764,
-0.018319903,
0.0076277414,
-0.033282265,
-0.015162217,
0.024262212,
-0.004939712,
-0.025274804,
0.039970696,
0.0061155166,
-0.029471727,
0.00022192064,
-0.00952635,
-0.007208049,
0.007687697,
0.0117513845,
-0.01356339,
0.020611556,
0.027899547,
0.024248889,
-0.0075344765,
0.018812874,
0.010618881,
-0.051322374,
-0.025088273,
-0.0072613433,
-0.01184465,
-0.01453601,
0.020784762,
0.017813606,
-0.00496969,
-0.0153221,
0.028379194,
-0.014442745,
-0.038664985,
-0.026314043,
-0.039517697,
0.011971223,
0.012863902,
-0.0048697633,
-0.004939712,
-0.0069549014,
0.017587107,
0.03248285,
0.022023853,
-0.007760977,
0.002033509,
0.0013798218,
-0.04234229,
-0.024861773,
0.019066023,
0.018879492,
0.024728538,
0.011151824,
0.007574447,
-0.020891352,
-0.015855042,
-0.014096333,
-0.008060757,
-0.010785426,
0.018599698,
0.014242891,
0.013443477,
0.0048431163,
-0.004756513,
0.007834257,
-0.00018694627,
-0.007914198,
0.015455336,
-0.03983746,
-0.01072547,
0.013170345,
0.005855707,
-0.0053993748,
0.008120713,
-0.010212513,
-0.024408773,
-0.031710085,
0.014482716,
0.025994277,
0.007421226,
-0.021384323,
0.016014926,
0.011311707,
0.027713016,
-0.0092665395,
-0.032909207,
0.00803411,
0.0075344765,
-0.014629275,
-0.013503433,
-0.6408102,
-0.029924728,
-0.0081540225,
-0.021530882,
0.030724142,
0.035893686,
-0.0031310378,
0.005675839,
-0.012790623,
0.020265143,
-0.004323497,
0.037679043,
0.013856508,
-0.0078009474,
-0.0026613823,
-0.012737328,
0.005222838,
-0.010678838,
0.008960098,
-0.027046839,
-0.019119317,
0.01598828,
0.007900874,
0.030990614,
-0.0006882454,
0.016681105,
0.058357216,
-0.0024681906,
-0.0020301782,
0.019305846,
-0.0038871502,
0.026687102,
-0.012990477,
-0.003920459,
0.042662058,
-0.03568051,
-0.007940845,
0.02586104,
0.0062154434,
0.021517558,
-0.029045373,
-0.023502769,
0.022503503,
0.010399043,
0.01666778,
0.023862505,
0.014069685,
0.0039137974,
0.012430887,
0.0021101197,
-0.0043967767,
-0.0059822807,
-0.0057424568,
0.0039404444,
0.042981822,
0.0040603564,
0.011864635,
-0.018986082,
0.01330358,
-0.003957099,
-0.0025398047,
0.0038871502,
-0.02085138,
0.012011195,
0.01214443,
-0.00205516,
-0.012530813,
0.0040603564,
-0.001418127,
-0.021477588,
0.015775101,
0.022223707,
0.0050429697,
-0.015348747,
0.01681434,
0.023875829,
-0.008700288,
0.029231902,
-0.012171078,
0.017467195,
0.0038138707,
0.0020368402,
-0.034001738,
0.003277597,
0.026140835,
-0.0020967962,
-0.010179204,
0.014549334,
-0.022623414,
-0.015268806,
0.005389382,
0.02066485,
0.009546335,
-0.029924728,
-0.037652396,
0.008793553,
-0.030884026,
0.00073321245,
0.012324298,
-0.018706286,
-0.02776631,
0.021530882,
-0.0045633214,
0.009226569,
0.028166017,
0.0010100928,
-0.015348747,
0.004443409,
0.028912136,
-0.030004669,
0.012457534,
0.0055392724,
-0.017080812,
-0.006441944,
0.026087541,
-0.029951375,
-0.00031476925,
-0.0071614166,
-0.023782564,
-0.008067419,
0.023063092,
-0.0011275067,
0.0015521954,
0.017467195,
-0.006275399,
0.022623414,
0.00018767492,
-0.011764708,
0.019039376,
-0.012650725,
0.0061221784,
0.0098994095,
0.030617554,
-0.0082339635,
0.024248889,
0.021211116,
0.03642663,
-0.0071947253,
-0.017693695,
-0.00631537,
-0.025314774,
0.00054668257,
-0.0024465397,
-0.0027346618,
-0.017986814,
-0.062833935,
0.01689428,
0.0018969426,
-0.001998535,
-0.013057094,
0.017613754,
-0.014376127,
0.009166613,
0.019265875,
-0.0018619683,
-0.01816002,
-0.013236962,
-0.029338492,
-0.024955038,
-0.00429685,
0.018000137,
0.02963161,
-0.021997206,
-0.02757978,
-0.019825466,
-0.023143033,
0.0008223138,
0.012917196,
0.013483448,
-0.03493439,
-0.011125177,
-0.02141097,
-0.0040736804,
0.0012515824,
-0.014962364,
0.018999405,
0.0072879903,
0.00310106,
-0.019066023,
0.0038538412,
0.018506432,
-0.020038642,
-0.0031543542,
0.016374663,
0.029551668,
0.0010933651,
0.006338686,
-0.0132569475,
0.017067488,
0.043941118,
-0.0076810354,
0.028006135,
-0.0012099463,
0.016174808,
0.0038271942,
-0.017573783,
-0.00291453,
0.0090533625,
-0.018586373,
0.01513557,
0.009253216,
0.0011932919,
0.02395577,
-0.0069349157,
0.00459663,
-0.02145094,
0.011071883,
-0.018213315,
0.02776631,
0.00724802,
-0.012990477,
-0.011971223,
-0.0062154434,
-0.02029179,
0.00082814286,
0.01434948,
-0.008653656,
-0.0033092406,
-0.017920196,
0.02021185,
0.0043967767,
0.0092931865,
0.025741128,
0.01412298,
-0.01648125,
-0.0070681516,
0.015561924,
0.002799614,
-0.018173343,
-0.010072616,
0.0077676387,
0.016827663,
-0.006438613,
0.0190527,
0.008726936,
0.017280664,
0.008547068,
-0.019905407,
0.024128977,
0.01244421,
0.0015138901,
0.013869831,
0.014416098,
0.00047839928,
0.0073146373,
0.0044334163,
0.026180806,
0.0106655145,
-0.02702019,
0.014282863,
-0.010152557,
-0.007840918,
-0.01311705,
-0.0017853578,
-0.0006811673,
-0.007960831,
-0.00073612697,
0.0283259,
0.018959433,
0.023289593,
0.0013082076,
-0.0092132455,
-0.01042569,
-0.008080742,
0.0068549747,
0.00952635,
0.0075611235,
0.001853641,
-0.015175541,
-0.020398378,
-0.025194863,
-0.006102193,
0.028912136,
-0.018213315,
0.0067883567,
-0.025754452,
0.005482647,
0.012763976,
0.011391648,
0.02010526,
-0.010765441,
-0.034481388,
0.0022316973,
0.01569516,
0.00023670147,
-0.0037672382,
-0.0037605762,
0.017866902,
-0.0016604493,
0.013183668,
0.007367932,
0.01184465,
0.0048964103,
0.0038138707,
-0.014003067,
-0.042742,
0.02795284,
-0.005392713,
0.0019718877,
0.0072813286,
-0.004573314,
0.00051004277,
-0.03512092,
-0.016427957,
0.010812073,
-0.0051462273,
-0.02776631,
-0.0501499,
-0.00422357,
0.014602628,
0.019852113,
0.0038538412,
-0.021650793,
0.021064557,
0.0012266007,
0.014136303,
-0.04092999,
0.007634403,
0.029578315,
-0.0091066575,
-0.027899547,
-0.040237166,
-0.003527414,
-0.00045175213,
0.03493439,
0.014469392,
0.0029911404,
0.045353416,
0.020318437,
0.01049897,
0.013097065,
-0.028059429,
0.009046701,
0.012310974,
0.01913264,
0.013037109,
0.016001603,
-0.016561192,
-0.011085207,
0.00054002076,
0.010405704,
-0.02294318,
-0.0043701297,
-0.015495307,
-0.0024881759,
0.006008928,
0.016174808,
0.04244888,
0.00631537,
-0.03743922,
0.012284327,
0.024528684,
0.02739325,
-0.011851312,
-0.016228102,
-0.0051928596,
-0.013896479,
0.021237763,
-0.020118583,
-0.023715947,
0.033095736,
-0.0062320977,
-0.002787956,
0.02070482,
0.023795888,
0.015895013,
0.00092432235,
-0.0075211525,
-0.0064486056,
0.010099263,
0.018972756,
0.026327366,
-0.0030960636,
-0.022769973,
0.021650793,
-0.0025614554,
-0.004813138,
-0.022623414,
0.018399844,
-0.0031493579,
-0.0035607228,
-0.013450139,
-0.010119248,
-0.02679369,
-0.01293052,
-0.02141097,
0.007394579,
-0.007987478,
-0.008866833,
-0.018173343,
-0.039251223,
-0.02122444,
-0.03464127,
-0.0076144175,
0.0039371136,
-0.023262946,
-0.021011263,
0.02249018,
0.017826932,
0.014296186,
0.009812806,
0.006808342,
0.007081475,
0.05814404,
-0.022716679,
-0.0045499974,
-0.0016138168,
-0.02484845,
0.017920196,
0.016907604,
0.006568518,
0.0016387985,
-0.023036445,
0.028858842,
0.0056558535,
-0.003950437,
-0.006508562,
-0.018786227,
-0.012484181,
0.003620679,
-0.0028745593,
0.021850647,
-0.025114922,
-0.0117780315,
-0.024222242,
-0.034667917,
-0.02428886,
-0.0100592915,
-0.0030427694,
0.004506696,
-0.023795888,
-0.00058332237,
-0.013143698,
-0.008773568,
0.02480848,
-0.012504166,
-0.0007723504,
0.014149627,
0.03789222,
0.046845656,
-0.011764708,
0.02275665,
0.01598828,
-0.016534545,
-0.0035673846,
0.034854446,
0.013523419,
0.009326496,
-0.021024587,
0.012757314,
0.00016342186,
-0.020051965,
-0.028086076,
-0.0029911404,
-0.000716558,
0.030377729,
0.0003982497,
-0.028752254,
-0.027446546,
-0.011331692,
-0.019558994,
0.017853579,
-0.013396845,
-0.049856782,
0.00870695,
-0.009446408,
-0.017800283,
0.00029311844,
0.03418827,
-0.020091936,
0.00915329,
0.009592967,
-0.025567923,
0.011977885,
0.014189597,
0.005602559,
-0.0053260955,
0.019998671,
-0.03733263,
-0.03008461,
-0.006008928,
-0.017373929,
0.02757978,
0.019452406,
0.03306909,
-0.0020501637,
0.0021317704,
0.0132835945,
-0.00007478892,
-0.0012907204,
-0.010878691,
0.0038771576,
-0.007148093,
0.01625475,
0.01356339,
0.0025314775,
0.0092132455,
-0.021517558,
0.008953436,
-0.010545602,
-0.01625475,
-0.025914336,
-0.0016829328,
-0.018639669,
-0.006961563,
-0.021837324,
-0.0024165616,
0.0057824273,
-0.030324435,
-0.021024587,
0.0014339488,
-0.02530145,
0.02021185,
0.0030327765,
0.011464928,
-0.038958106,
0.03778563,
-0.008607023,
0.008933451,
0.012690696,
0.00006110104,
-0.0075144907,
-0.012324298,
0.0022483517,
0.01644128,
0.024915067,
0.011031913,
-0.02178403,
-0.0024581978,
0.0052827937,
-0.011171809,
-0.009219907,
-0.03725269,
-0.029684903,
0.008686964,
-0.014336157,
0.021357676,
-0.024715213,
0.0053727278,
0.0041269744,
-0.021357676,
0.014669246,
-0.033095736,
0.0027146765,
-0.021890618,
-0.027979488,
0.0038038779,
-0.019452406,
0.009126643,
0.043354884,
-0.008686964,
-0.012570784,
0.0049530356,
-0.005579243,
-0.010299116,
0.037945513,
0.046472598,
-0.007414564,
0.0026097533,
0.00095013675,
0.024528684,
-0.026700426,
-0.02749984,
-0.003990408,
-0.0011316703,
0.0009551331,
-0.0015047302,
-0.019758848,
-0.031150496,
0.036266744,
-0.011758046,
0.00031976556,
0.0007815104,
-0.007860904,
0.002484845,
-0.008193993,
-0.017440546,
0.011464928,
0.017347282,
0.0009984347,
-0.0027629745,
-0.034214918,
-0.005509294,
0.018120049,
-0.022370266,
0.014815805,
0.006778364,
0.023609359,
0.0066584516,
0.0010134237,
0.028059429,
-0.00006464011,
-0.017453872,
0.036799688,
0.0035640537,
-0.020544939,
0.0038438486,
0.005089602,
0.012710681,
-0.047698364,
-0.011451605,
-0.010865368,
-0.022996474,
0.0000593315,
0.024688566,
0.0027529816,
-0.004323497,
-0.014469392,
-0.016880957,
0.010865368,
0.0028845519,
-0.03418827,
0.008693626,
-0.042502172,
-0.0015255483,
-0.011831326,
-0.01259077,
0.0046765716,
0.0063520097,
-0.010918662,
-0.0055925664,
-0.0046832333,
-0.016801016,
0.01602825,
0.006894945,
-0.008047434,
0.0054759854,
0.014376127,
-0.025727805,
-0.013696625,
0.008107389,
0.0116181495,
-0.016587839,
-0.0078009474,
0.002160083,
0.013137036,
0.019598965,
-0.021384323,
0.009799482,
0.00001678457,
0.00822064,
-0.0044534015,
-0.008720273,
0.011691429,
-0.0024981685,
0.011464928,
-0.0012232699,
-0.014256215,
0.0107987495,
-0.028858842,
0.020078612,
-0.006968225,
-0.045086946,
-0.012277666,
-0.015202188,
0.020451672,
-0.01606822,
0.0020967962,
-0.024408773,
-0.0014347815,
-0.015295453,
0.013290256,
0.0059323176,
-0.0073479465,
-0.004926388,
0.012197725,
0.013316903,
-0.008880156,
0.007967493,
0.005692493,
0.007727668,
0.000291453,
0.004813138,
-0.00017143681,
-0.024861773,
0.05425356,
0.005299448,
-0.012757314,
-0.0150023345,
-0.014602628,
-0.041782703,
0.009572982,
-0.013336889,
0.011678105,
0.0014914066,
-0.009513026,
0.010792088,
0.010432351,
-0.0090000685,
-0.0069815484,
-0.035920333,
-0.019145964,
0.004739858,
0.0038205325,
0.033388857,
-0.003067751,
-0.040610228,
0.0064019733,
0.032269675,
-0.0019918731,
-0.0052594775,
0.041782703,
-0.006461929,
-0.006828327,
-0.011944576,
-0.010139233,
-0.0060255826,
-0.011384986,
0.019372465,
-0.0063286936,
-0.00840717,
0.01035241,
0.01012591,
-0.011318369,
-0.0073546083,
-0.008806877,
-0.0034441417,
0.0036739733,
-0.014282863,
-0.008980083,
-0.0029545007,
-0.015828395,
0.017054163,
-0.0061155166,
0.00040616057,
0.008840186,
0.0076743737,
-0.022543473,
0.013523419,
0.011085207,
-0.013576713,
-0.010045968,
-0.00026792858,
-0.009879424,
-0.019359142,
-0.0020151893,
0.009399775,
0.0044267545,
-0.010778764,
0.012903873,
0.0061521563,
-0.025168216,
0.017613754,
0.007341285,
-0.02062488,
-0.013896479,
0.0030377728,
-0.004576645,
0.0019219243,
-0.008020787,
0.016707752,
-0.035147566,
0.015601895,
0.008187331,
-0.022690032,
0.016587839,
0.009786159,
-0.019372465,
0.00040199695,
0.00080565934,
0.18834192,
-0.00078192673,
-0.0010042638,
0.01602825,
0.0023232966,
-0.0053227646,
0.018506432,
0.022290325,
-0.0065118927,
0.016348016,
0.010578911,
-0.0038538412,
0.008353876,
0.008247287,
0.029951375,
-0.0150289815,
-0.021797353,
-0.015402041,
-0.007081475,
-0.019892083,
-0.000020987218,
-0.011011926,
-0.0005883187,
0.00717474,
-0.0006424457,
-0.008940113,
-0.018026784,
0.01625475,
0.023849182,
-0.0018702955,
-0.0150289815,
0.015535277,
0.019625612,
0.022663385,
0.008873494,
-0.024928391,
-0.0132303005,
-0.014962364,
-0.00015051465,
0.00060164224,
-0.011444943,
0.015815072,
-0.016427957,
0.0029461733,
-0.019079346,
-0.014442745,
-0.0059323176,
-0.03224303,
-0.006681768,
-0.00840717,
-0.014629275,
-0.008487111,
0.013057094,
-0.010359072,
0.0013964762,
-0.01816002,
0.009619614,
0.01793352,
-0.01293052,
-0.0092398925,
0.026247423,
0.029471727,
-0.028192665,
0.012677372,
-0.012903873,
0.0278729,
-0.016907604,
-0.0124109015,
-0.028086076,
0.0017670379,
0.0070748134,
-0.015535277,
-0.021371,
-0.0005375226,
-0.019718876,
-0.017067488,
0.020198526,
0.018040108,
0.025701158,
0.036533218,
-0.017440546,
-0.0024865104,
-0.03687963,
-0.0009876093,
-0.020065289,
-0.030031316,
0.0130038,
0.00620212,
-0.010518955,
0.028459135,
0.013430154,
0.0024831796,
0.00005063996,
0.0045266813,
0.01546866,
-0.005089602,
-0.010938647,
0.013883155,
-0.0072813286,
0.009892748,
-0.004020386,
0.07935516,
-0.010439013,
-0.007694359,
-0.023262946,
-0.010372396,
0.0037739,
0.013816537,
-0.0099260565,
-0.0019086008,
0.01393645,
-0.033735268,
-0.02070482,
-0.014695893,
-0.008793553,
0.024715213,
0.0034241562,
-0.0074878437,
0.009346481,
-0.00736127,
0.0040270477,
-0.007807609,
0.0076743737,
0.03224303,
-0.00799414,
-0.012037842,
-0.017120782,
-0.00019038127,
-0.022543473,
-0.0091333045,
-0.010139233,
-0.017773636,
0.016001603,
0.0034274873,
-0.023809211,
0.023396181,
0.015708484,
-0.014376127,
0.0018369866,
0.022956504,
0.0060222517,
-0.001433116,
0.008027448,
0.010452338,
0.004873094,
-0.02582107,
0.019519024,
0.0035673846,
-0.0012773968,
-0.011997871,
-0.016694428,
-0.0053993748,
0.005952303,
-0.009999336,
0.01588169,
-0.022623414,
-0.036799688,
-0.026940249,
0.008453802,
0.004043702,
-0.0020201856,
-0.006901607,
0.02936514,
0.019119317,
-0.009086671,
0.00138232,
-0.16840987,
0.0062121125,
0.020771438,
0.0054393457,
0.041382995,
0.014655922,
0.02242356,
-0.0055692503,
0.0028345885,
-0.00004231273,
0.02981814,
0.017493842,
-0.028459135,
-0.036346685,
0.008393846,
0.023942446,
-0.008353876,
0.023969095,
0.024315506,
-0.008253949,
0.021797353,
-0.02058491,
0.021890618,
0.010625543,
0.00050754455,
0.04002399,
-0.0017154091,
0.047218718,
-0.016694428,
-0.00056583516,
-0.031337027,
-0.00028458305,
0.03893146,
-0.0031793357,
-0.0022366936,
-0.0019069354,
0.012763976,
0.011678105,
0.0045799757,
0.022130443,
0.016294722,
0.007834257,
0.02596763,
-0.0073479465,
-0.017240694,
0.010565587,
0.007780962,
-0.013030447,
0.012883888,
-0.017760312,
0.004510027,
-0.0325095,
0.0008635336,
0.007327961,
-0.017160753,
-0.0006890782,
-0.0044101,
0.020784762,
-0.006102193,
0.001973553,
-0.012737328,
-0.01606822,
0.011944576,
0.0047964836,
0.023183003,
-0.029418433,
-0.0019502369,
0.011531546,
-0.02944508,
0.017240694,
-0.016880957,
-0.02211712,
0.010079278,
-0.03733263,
0.036533218,
0.0008527082,
0.015308777,
0.02739325,
0.00021203206,
0.013909803,
-0.009686233,
0.019612288,
-0.038052104,
-0.005159551,
0.0106855,
0.015948309,
-0.010505632,
0.030057963,
0.017054163,
-0.002728,
0.02223703,
-0.032829266,
0.031337027,
-0.000005624132,
0.024035713,
0.013829861,
-0.01550863,
0.017067488,
0.009946042,
-0.008040772,
0.004316835,
-0.012877226,
-0.017134106,
0.02861902,
0.03157685,
-0.025274804,
-0.0150023345,
0.006012259,
0.037279338,
-0.021091204,
-0.01472254,
0.0058223982,
0.010099263,
0.01931917,
-0.015295453,
0.038398515,
-0.008720273,
-0.01087203,
-0.010465661,
-0.0115915015,
0.032749325,
0.008307243,
-0.006961563,
-0.0016471258,
-0.012017856,
-0.0018403175,
-0.114156306,
-0.03213644,
0.01449604,
-0.0071880636,
-0.015628543,
0.023196328,
0.0040103933,
-0.0062121125,
0.002066818,
0.03131038,
0.010785426,
-0.026660455,
-0.010012659,
-0.011764708,
0.0394644,
-0.0026863639,
-0.0034141636,
-0.041756053,
-0.03344215,
0.044554003,
0.011345016,
-0.0075811087,
0.0012840587,
0.0051428964,
0.0015097265,
-0.037226044,
-0.008620347,
0.017773636,
0.012264342,
0.026207453,
0.02899208,
-0.001481414,
0.006368664,
0.0057224715,
-0.032429557,
-0.016134838,
-0.009099995,
0.005802413,
0.031923264,
-0.03464127,
0.019492377,
0.015108923,
0.022996474,
-0.006555194,
0.025834393,
-0.016960898,
-0.020118583,
0.00015925824,
-0.00094680587,
-0.016907604,
-0.01610819,
-0.020784762,
-0.01834655,
0.002806276,
0.017134106,
-0.035493977,
-0.00426021,
0.026287396,
-0.01606822,
-0.003993739,
-0.0036606495,
0.0076144175,
-0.033575386,
0.0019585642,
0.0021351015,
-0.011804679,
-0.007854242,
-0.045033652,
-0.0048397854,
-0.042502172,
-0.027313309,
0.008487111,
-0.015348747,
0.00680168,
-0.035227507,
-0.0032476191,
-0.03743922,
-0.009692894,
0.008140698,
-0.019225905,
0.008653656,
-0.027899547,
0.024901744,
-0.0066751065,
0.012350945,
0.007321299,
0.02238359,
0.002941177,
-0.0028912136,
-0.0046832333,
0.011851312,
0.019225905,
0.013723273,
-0.008613685,
-0.0014422759,
0.020691497,
-0.018213315,
-0.019985348,
0.024821803,
0.003800547,
-0.014202921,
-0.005249485,
-0.06421959,
0.031550203,
0.016427957,
-0.0064685913,
0.0003851343,
-0.016467927,
0.007867565,
0.0061721415,
0.0054426766,
0.009146628,
-0.03594698,
0.01931917,
-0.0255546,
-0.0009276532,
-0.009686233,
-0.0063620023,
0.021943912,
0.012510828,
0.02851243,
0.0069149304,
-0.006342017,
-0.0037039511,
0.0069082687,
0.029578315,
-0.0042102467,
0.013623346,
-0.0071014604,
0.013276933,
0.0098727625,
-0.0059056706,
0.023236299,
-0.034481388,
-0.023982419,
0.004017055,
-0.022183737,
-0.024768509,
0.012091136,
0.011871297,
0.03834522,
0.020278467,
-0.00485644,
-0.019399112,
0.005182867,
-0.0045633214,
0.010971956,
-0.002902872,
-0.004440078,
0.033122383,
-0.010838721,
0.0030960636,
0.027273338,
-0.00031018927,
0.0031593505,
-0.041223112,
0.002869563,
0.008533744,
0.0108253965,
0.027419899,
-0.012051165,
-0.011551531,
0.011931253,
-0.006112186,
0.002331624,
0.019892083,
0.019292522,
-0.018866168,
0.0036706424,
0.00009701221,
-0.008826862,
-0.035414036,
-0.03147026,
0.002668044,
-0.022929857,
0.012084474,
0.011611488,
-0.010632205,
-0.013643331,
0.021437617,
0.0010750452,
0.017080812,
-0.018786227,
0.003434149,
-0.018599698,
0.00019589804,
0.01263074,
-0.020838056,
-0.0051029255,
0.025754452,
-0.015042305,
0.014216244,
-0.014016391,
-0.005615883,
0.007900874,
0.010931985,
-0.010392381,
0.027073486,
0.010325763,
-0.022650061,
-0.009912733,
0.010199189,
-0.007634403,
0.002463194,
-0.021131175,
-0.017347282,
-0.011478252,
0.014442745,
-0.0054393457,
-0.043035116,
-0.008653656,
0.025781099,
-0.0028429157,
0.033868503,
0.004043702,
0.010938647,
-0.019012729,
0.006441944,
0.013250286,
-0.013736596,
0.00029311844,
0.0236893,
-0.0050129914,
0.004456733,
0.019798819,
-0.021344353,
0.010858706,
0.008646994,
0.024422096,
-0.005179536,
0.054626618,
-0.0028129378,
-0.00016269322,
-0.0150956,
-0.035227507,
-0.010205851,
0.012164415,
-0.0301912,
-0.0039670914,
0.016787693,
0.005639199,
0.08399176,
-0.022090472,
-0.02451536,
0.015974956,
0.004266872,
0.017840255,
-0.0003322564,
-0.008247287,
-0.004270203,
-0.020784762,
0.00799414,
-0.010971956,
0.021104528,
-0.021903941,
-0.012237695,
-0.010792088,
0.010838721,
0.009199922,
-0.016454604,
-0.029711552,
0.0041869306,
0.001313204,
0.013450139,
0.028006135,
-0.030244494,
-0.0092398925,
0.01449604,
-0.00620212,
0.019239228,
-0.04498036,
-0.0054093674,
0.027926194,
-0.023302916,
-0.022556797,
0.021197792,
-0.007860904,
-0.03456133,
0.0065851724,
0.03408168,
-0.015162217,
-0.015775101,
0.010698823,
-0.027553134,
0.010558926,
-0.016641133,
-0.032935854,
0.0046366006,
-0.013250286,
-0.011158486
] |
OBJECTIVE Mitochondrial disorders are caused by gene mutations in mitochondrial or nuclear DNA and affect energy-dependent organs such as the brain. Patients with psychiatric illness, particularly those with medical comorbidities, may have primary mitochondrial disorders. To date, this issue has received little attention in the literature, and mitochondrial disorders are likely underdiagnosed in psychiatric patients. DATA SOURCES This article describes a patient who presented with borderline personality disorder and treatment-resistant depression and was ultimately diagnosed with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) 3271. We also searched the literature for all case reports | [
-0.017527904,
-0.0029397656,
0.0135951955,
-0.03781652,
-0.04250452,
0.024351547,
-0.0008155164,
0.009786197,
-0.0131329065,
0.020392792,
-0.017879505,
0.028258212,
0.019403104,
0.018348305,
-0.010600085,
0.006084631,
0.044457853,
-0.01157024,
0.0059478977,
0.0012468774,
-0.00921973,
0.017345594,
-0.004385232,
-0.018465504,
0.014259328,
0.013425906,
0.0071687307,
-0.0332327,
-0.027502924,
-0.01455884,
-0.0058274423,
-0.011413974,
-0.0025377048,
-0.021799192,
0.006511109,
-0.0024758491,
0.007461731,
-0.0007715664,
0.028909324,
-0.012019507,
0.004339654,
0.009727596,
-0.00834073,
-0.0024937547,
-0.0041736206,
0.029195812,
-0.004010843,
-0.018257149,
-0.0044242986,
0.01925986,
0.037608165,
0.030550122,
-0.0074877753,
0.0016814938,
-0.0007919136,
-0.02071835,
0.01203904,
-0.010756352,
-0.0046359096,
-0.020549059,
0.0008781858,
-0.01432444,
-0.02911768,
-0.00013948017,
-0.0115637295,
0.017957639,
0.018179016,
0.024325503,
0.0044080205,
0.0045805653,
0.03529021,
0.00035404155,
-0.0037731875,
0.01925986,
0.017462794,
-0.023361858,
-0.012807351,
-0.022294037,
-0.014988572,
0.013764484,
0.020601148,
-0.00558002,
0.008705352,
0.02267168,
0.0077547305,
-0.023908792,
-0.016629372,
0.0027069936,
0.020653237,
-0.00061000953,
-0.0026711824,
0.017645106,
0.019715637,
0.008900686,
-0.005908831,
0.021291327,
-0.0010906107,
0.01203904,
-0.005895809,
-0.023153502,
-0.0052577206,
0.012058574,
-0.04844265,
-0.011986951,
-0.010574041,
0.00015199369,
-0.0045903316,
0.0070710643,
0.0022463326,
-0.020457905,
-0.014584884,
0.03547252,
-0.028987456,
-0.014806261,
0.031617943,
0.004798687,
0.023557192,
-0.013959818,
-0.01274224,
0.0053391093,
0.020366749,
0.0041833874,
0.015235995,
-0.016056394,
-0.0024563158,
0.003805743,
-0.027867546,
0.0034899544,
-0.008803019,
0.0047205538,
0.0041736206,
-0.0055572316,
0.0016464966,
-0.004157343,
-0.024703147,
0.007976108,
-0.01015733,
-0.016069416,
-0.022554481,
-0.0329983,
0.00065070397,
0.035133943,
-0.02319257,
-0.0003931082,
-0.015978262,
0.03917083,
0.0027379212,
0.011531173,
0.023348836,
-0.00315626,
-0.0013201273,
-0.00047042762,
0.0061269533,
-0.0026923434,
-0.0055962983,
0.020796482,
0.008093309,
0.011199107,
-0.026825769,
-0.024468746,
0.0004960651,
-0.010775886,
-0.022645637,
0.012872462,
0.01996306,
0.035420433,
0.0061627645,
-0.028466567,
0.008549086,
-0.029638568,
0.002148666,
0.027346658,
-0.03307643,
0.032972254,
-0.008444908,
0.004245243,
-0.019689593,
0.01855666,
-0.019858882,
-0.017710216,
-0.019663548,
0.020288615,
0.020913681,
-0.0007520331,
-0.025705857,
0.016460083,
0.014207239,
-0.013569151,
0.006094398,
-0.024625013,
-0.004303843,
0.004938676,
0.0070319977,
-0.014819284,
-0.63965136,
-0.0037764432,
-0.0069538644,
-0.00857513,
-0.011693952,
0.037191454,
-0.003164399,
0.011635351,
-0.011088419,
0.0052219094,
0.0003098881,
0.015574573,
0.0003076499,
-0.02319257,
-0.0022886547,
-0.0292479,
-0.011374907,
-0.0010727051,
0.0311231,
-0.004222454,
-0.020952748,
0.0020054216,
-0.016642394,
-0.0021014605,
-0.0019240327,
0.018283194,
0.01720235,
0.009818752,
0.017111193,
0.03523812,
-0.010014085,
0.008529552,
-0.019806793,
0.013881684,
0.045916338,
-0.015639683,
-0.001124794,
0.026122568,
-0.0022219159,
0.01790555,
-0.010294063,
0.0031220766,
0.03940523,
0.009603886,
-0.021069948,
0.033206657,
0.028935367,
-0.0053521316,
0.009825263,
0.0023586492,
0.008718375,
0.01902546,
-0.010880063,
-0.00045537067,
0.004554521,
-0.010795418,
0.0078068194,
-0.03982194,
0.023713458,
0.014037951,
-0.009779685,
0.023882747,
-0.002213777,
-0.024820346,
-0.0003558728,
0.0013282662,
-0.02084857,
0.0021388992,
-0.010606596,
-0.0038415543,
0.0023130714,
0.015665729,
-0.025328213,
0.015196928,
0.03497768,
0.023296747,
0.016473105,
0.012989662,
-0.05081269,
0.015496439,
-0.01925986,
-0.0035127432,
-0.019520305,
-0.02160386,
0.039665677,
-0.0006201831,
0.0039717765,
0.020288615,
-0.0019793771,
0.0027753601,
0.01274224,
-0.0044308095,
-0.0053293426,
-0.019989105,
-0.0089788195,
0.0040889764,
-0.023101414,
0.0033694988,
0.015509461,
-0.000028816743,
-0.011830685,
0.0017742772,
-0.0070710643,
0.0041736206,
0.018283194,
0.0055767647,
-0.0315919,
0.0040661874,
0.03351919,
-0.007481264,
0.0028551212,
-0.016759595,
0.0020933214,
-0.0014234912,
0.0037341209,
-0.022450304,
0.02541937,
-0.008757441,
-0.01896035,
0.0017710216,
-0.0053228317,
-0.008829064,
0.006501342,
-0.023453014,
-0.0088876635,
0.007819842,
0.017527904,
-0.014545817,
-0.013543107,
-0.0015073217,
-0.018192038,
0.00031110892,
0.034795366,
0.0004582193,
0.018712927,
-0.0009970135,
0.037425853,
-0.011693952,
-0.000533097,
-0.012781306,
-0.013315218,
-0.010033619,
-0.0012623413,
0.022385193,
-0.014480706,
-0.01820506,
-0.017658127,
-0.012690151,
-0.031930476,
0.014129106,
-0.010424285,
-0.0021307603,
-0.017918572,
0.03547252,
0.007761242,
-0.016538216,
-0.009708064,
-0.0035745988,
0.00060797477,
0.002309816,
0.019754704,
0.017710216,
-0.021877326,
0.0039034097,
-0.012136707,
-0.035915278,
-0.003120449,
0.013250106,
-0.032086745,
-0.010587063,
-0.02218986,
-0.0063027535,
-0.0066217976,
-0.011296774,
-0.009551797,
0.012188796,
0.011322819,
-0.018699905,
0.000023310278,
-0.0015626661,
0.012729217,
0.0019630992,
-0.0058274423,
-0.004967976,
0.0058046533,
0.017241416,
0.04305145,
-0.0018393883,
-0.010671708,
0.03200861,
0.0008716747,
0.058756247,
0.0034606543,
0.017840438,
0.018348305,
0.02120017,
0.0047889207,
-0.014077017,
-0.017046083,
0.030550122,
0.012299485,
-0.036097586,
0.007722175,
-0.01638195,
0.034066122,
-0.029925056,
0.0033108988,
-0.013119884,
-0.00044479012,
0.0008659775,
0.00006327984,
0.006765042,
0.004629398,
-0.008080286,
-0.014819284,
0.005859998,
0.004736832,
0.013360796,
-0.00037296445,
-0.031383544,
-0.00035526237,
0.0017661382,
0.02218986,
0.027164346,
0.025224036,
0.024403635,
0.005518165,
0.016655417,
0.013145928,
-0.00061611366,
0.009389019,
-0.0020558827,
0.016876794,
0.017306527,
-0.003675521,
0.00062059006,
0.0015366217,
-0.0065469197,
0.04904167,
0.010150819,
0.005514909,
0.020952748,
-0.012983151,
0.005508398,
0.0129050175,
-0.009525753,
0.030107368,
0.012839907,
-0.017514883,
0.0037796986,
-0.008379797,
0.016577283,
-0.021655949,
-0.014207239,
-0.01455884,
-0.008737908,
-0.00000769379,
0.008594664,
0.034378655,
0.0015333662,
0.012872462,
-0.032920167,
-0.010658685,
-0.01080193,
-0.0007211053,
-0.010482885,
0.017632082,
0.0036071544,
0.014363506,
0.010469863,
-0.029951101,
-0.0059153424,
-0.0013477996,
-0.04750505,
0.028961413,
0.0011785107,
-0.0023505103,
0.018100882,
0.02929999,
0.017332572,
-0.011283752,
-0.029508345,
0.022176838,
0.026656479,
-0.00933693,
-0.013145928,
-0.019585416,
0.007715664,
-0.030966833,
0.018035771,
0.005964176,
0.005859998,
0.011127485,
0.001972866,
0.0052512093,
0.0015097633,
0.008347241,
-0.011674418,
0.027607102,
-0.0052121426,
0.016694482,
0.010541486,
-0.01668146,
0.0077872863,
0.019741682,
0.023947857,
-0.047661316,
0.0064166975,
0.016512172,
-0.021174125,
-0.008301664,
-0.005078665,
-0.015040661,
0.008177953,
-0.0038089987,
0.0011654885,
-0.0078068194,
0.023687413,
0.010235463,
0.0055051427,
-0.0021470382,
-0.03211279,
-0.009935952,
-0.0013461717,
0.031409588,
0.041879453,
-0.014467684,
-0.003675521,
0.021187149,
0.010697752,
0.01004013,
-0.025041724,
0.020184437,
-0.0006592498,
0.012833395,
-0.004193154,
0.02360928,
0.009883863,
0.020861592,
0.0145197725,
-0.012136707,
-0.011042841,
-0.010756352,
-0.005791631,
0.0031578878,
-0.0332327,
0.024833368,
0.044327628,
0.020236526,
-0.015418306,
0.004469876,
0.023531146,
0.0041443207,
-0.0076375306,
-0.033623368,
0.0036136655,
0.0047661318,
0.0351079,
-0.018426439,
-0.003965265,
0.016394973,
0.008763952,
0.014832306,
0.012598995,
0.026903901,
-0.0049451874,
0.0146109285,
0.0017710216,
0.020171415,
0.0046782317,
-0.015978262,
0.0015227855,
0.015496439,
-0.011309796,
0.019937016,
-0.024911502,
-0.010736818,
-0.026617413,
0.0044080205,
-0.01192184,
-0.0074356864,
0.00085458305,
-0.010606596,
0.008783486,
0.019155683,
-0.028544702,
0.014649995,
0.00028384366,
0.0071426863,
0.0060325423,
-0.008724886,
-0.0062376424,
-0.031097056,
-0.032451365,
-0.008347241,
-0.029169768,
-0.024807325,
0.007181753,
0.01726746,
0.01632986,
-0.001241994,
-0.018348305,
0.03927501,
0.02519799,
-0.037608165,
0.0044633653,
-0.0016717272,
-0.017775327,
-0.0051698205,
0.00634182,
0.014962528,
-0.01626475,
-0.0003448853,
0.033623368,
-0.008731397,
-0.010326618,
-0.0059218532,
0.032347187,
0.0021584325,
0.036774743,
0.009017886,
0.02695599,
-0.026474169,
-0.012631551,
0.016785638,
-0.030367812,
-0.02232008,
-0.03630594,
-0.0030699878,
-0.050942916,
-0.017059105,
-0.007546375,
0.011622329,
0.001644055,
0.015952216,
0.0027525714,
0.009271819,
0.022385193,
0.012468773,
0.014311417,
-0.011081907,
0.0306543,
0.011251196,
-0.0029251156,
-0.0033043877,
-0.013113373,
0.064277664,
0.0006633192,
-0.015053684,
0.017593017,
0.010111752,
-0.010515441,
-0.02073137,
-0.0057460535,
0.012319018,
0.034326565,
-0.011511641,
-0.04180132,
-0.038155098,
-0.0060162647,
-0.02043186,
0.025315192,
0.013451951,
-0.007344531,
-0.0003076499,
0.016460083,
-0.010775886,
-0.006390653,
0.030029234,
-0.037373766,
-0.024572924,
-0.011778596,
0.0055279313,
0.010241974,
-0.031852346,
0.008991841,
-0.02366137,
-0.0039066654,
-0.0060130088,
-0.027034124,
0.004287565,
-0.0054237535,
0.043598384,
0.004697765,
0.027086213,
0.011244685,
0.017606039,
0.0048930985,
-0.009467152,
0.0068041086,
0.006406931,
0.0041443207,
-0.011218641,
0.0091155525,
-0.01726746,
-0.014350484,
0.023518125,
-0.03187839,
0.013256618,
0.025445413,
-0.017944615,
-0.026122568,
-0.006947353,
-0.044405762,
0.015040661,
0.0019419382,
-0.025940258,
0.00534562,
-0.042608697,
-0.017879505,
0.033571277,
0.0005900692,
0.0073835975,
-0.002565377,
0.008594664,
-0.028883278,
0.018192038,
0.003922943,
0.0049354206,
-0.016512172,
-0.020978794,
0.006934331,
-0.020340703,
0.006211598,
0.0011597913,
0.01632986,
0.0013551245,
-0.014754172,
-0.0010401496,
0.0035713431,
-0.01750186,
-0.011225152,
-0.02789359,
-0.020171415,
-0.008132375,
0.0011972302,
-0.0105935745,
-0.027633145,
0.01239064,
-0.0005961734,
-0.0038024876,
0.020236526,
-0.015600617,
-0.01815297,
0.013517062,
-0.005547465,
-0.0061627645,
-0.014415595,
0.049067717,
-0.0067389975,
-0.0055539757,
-0.034717232,
0.016004305,
0.027971724,
-0.0018361327,
0.04703625,
0.002534449,
0.0015008106,
0.008243063,
0.00927833,
-0.009037419,
-0.014454662,
-0.01362124,
0.00054611923,
-0.0044308095,
0.0038773653,
-0.0135040395,
0.002073788,
-0.02354417,
0.010476374,
-0.03294621,
0.0327639,
-0.018921282,
-0.027919635,
-0.012188796,
0.002016816,
-0.009415063,
0.017879505,
-0.020991815,
0.01790555,
-0.005247954,
-0.016512172,
-0.024976613,
0.025497502,
0.0059055756,
0.0073184865,
0.0065501756,
0.0007854025,
0.00020225132,
0.021017859,
0.016863773,
-0.006384142,
-0.010795418,
0.044067185,
0.0062571755,
0.0057818647,
0.014728128,
-0.01432444,
0.01056753,
0.02859679,
-0.014819284,
-0.030602211,
-0.0110558625,
-0.0039359652,
0.019324971,
0.0015032522,
0.0074487086,
-0.011446529,
-0.030211546,
-0.028883278,
-0.018361326,
-0.036774743,
0.01748884,
-0.04141065,
-0.004632654,
-0.018100882,
0.005283765,
0.016629372,
-0.007344531,
0.01069124,
-0.012078106,
0.030914744,
-0.00601952,
0.012768284,
-0.0038708542,
-0.011029818,
-0.0046456764,
0.004704276,
0.0033369432,
-0.016225683,
0.0011402579,
-0.01180464,
-0.016004305,
-0.02284097,
-0.007311975,
0.017606039,
0.0010132913,
-0.008711863,
0.035732966,
-0.018179016,
0.009975019,
-0.023348836,
-0.026929947,
0.026695546,
-0.013302195,
0.013946795,
-0.010209419,
0.013217551,
-0.02595328,
-0.020119326,
-0.003340199,
0.00634182,
-0.006208342,
-0.023127459,
-0.010443819,
0.0062571755,
0.0013648912,
0.015157862,
-0.016941905,
-0.013985862,
-0.01972866,
0.0032392766,
0.021551771,
0.010495908,
-0.026200702,
0.015014617,
0.027372701,
0.01702004,
-0.017215371,
-0.019298926,
-0.014376529,
-0.0031530045,
-0.014545817,
-0.013438929,
-0.015496439,
0.018309237,
0.01485835,
0.0028046602,
-0.008190975,
-0.014037951,
-0.05349527,
0.012572951,
0.02448177,
0.028101945,
0.033441056,
0.028961413,
-0.013315218,
-0.019233815,
0.022359148,
0.019220794,
-0.04328585,
-0.0101768635,
0.025093812,
0.005208887,
0.011400951,
-0.019520305,
0.0024563158,
-0.0047107874,
0.0048344983,
-0.001819855,
-0.023023281,
-0.0020542548,
-0.005270743,
-0.013738439,
-0.005101454,
0.008334219,
-0.015769906,
0.010235463,
0.010808441,
-0.0283103,
-0.019520305,
-0.00092620525,
-0.0005164123,
-0.004925654,
0.006699931,
0.021395504,
0.00020235305,
0.0065892423,
-0.02929999,
-0.016720528,
-0.0063678646,
-0.015014617,
0.001731955,
0.027737323,
0.0072598862,
0.012787818,
-0.010124775,
-0.018882215,
-0.011433507,
0.0001370385,
0.016564261,
-0.008698842,
0.039900076,
0.011003774,
-0.025406346,
0.011752551,
0.0035485544,
-0.031904433,
-0.0064166975,
-0.026109546,
-0.007344531,
-0.043650474,
-0.00986433,
-0.006507853,
-0.02290608,
-0.023778569,
0.010958197,
-0.021395504,
0.013790528,
-0.018179016,
0.009877352,
-0.0075007975,
-0.0027607102,
0.011811151,
-0.03359732,
-0.007891464,
0.019858882,
-0.02379159,
-0.042322207,
0.007956575,
0.16741364,
-0.017879505,
-0.0073315087,
0.01849155,
0.0008594664,
-0.0031139378,
0.020770438,
-0.0022365658,
-0.021395504,
0.022827948,
0.03495163,
-0.00425501,
0.008542575,
0.012781306,
0.03094079,
-0.012514351,
-0.04099394,
-0.0067520197,
-0.024455724,
-0.008900686,
-0.008724886,
-0.0028941878,
0.012351573,
-0.010241974,
0.03146168,
-0.0039489875,
-0.017163282,
-0.00044072067,
0.028727012,
0.012891996,
0.0016847494,
-0.013158951,
0.00018536313,
-0.010561018,
0.01145304,
-0.0028453546,
-0.00086679135,
-0.021812215,
-0.0018882216,
0.003506232,
-0.012123684,
0.0035680877,
-0.013295684,
0.011908818,
-0.0009082997,
0.040967897,
0.0029544155,
-0.02185128,
-0.004567543,
-0.0001559614,
-0.04680185,
0.004648932,
0.01890826,
0.016629372,
0.0007292442,
-0.0125794625,
0.021356437,
0.02953439,
-0.012429707,
0.0033564765,
0.000686922,
-0.004873565,
-0.03000319,
0.04250452,
-0.00028160546,
0.011654885,
-0.0141030615,
-0.0070905974,
0.0019679826,
-0.007233842,
-0.013464973,
-0.024143191,
0.00040511304,
-0.008210508,
0.018569682,
-0.017189328,
0.048494738,
0.0120715955,
-0.002169827,
0.017853461,
0.000036803027,
-0.010170352,
-0.018856172,
0.0036006432,
-0.008816041,
-0.04427554,
0.02073137,
0.012559929,
-0.01649915,
-0.037946742,
-0.0033369432,
-0.0073380196,
-0.009792708,
0.022150792,
-0.010183374,
0.014962528,
0.011264218,
-0.026213724,
-0.014402573,
-0.029925056,
-0.011869751,
0.092249386,
0.0036494764,
-0.00898533,
-0.024208302,
0.007012464,
-0.009265308,
0.0024498047,
0.006039053,
-0.00064134423,
0.0024498047,
-0.030237589,
-0.0073054642,
-0.0055279313,
-0.016746571,
0.033128522,
0.027294569,
-0.019181727,
0.02207266,
-0.029221857,
0.0049972762,
-0.043650474,
0.012319018,
-0.0016391716,
-0.011544196,
0.0051763314,
-0.014363506,
-0.0060130088,
0.0028974435,
-0.008262597,
0.008711863,
-0.01797066,
-0.0018768271,
0.015249017,
-0.02583608,
0.0055539757,
0.024533859,
0.016342884,
-0.010613107,
0.012716196,
-0.018595727,
0.007852397,
0.012820373,
-0.007494286,
-0.0022821436,
-0.025471458,
0.01621266,
0.0115181515,
-0.011739529,
-0.020041194,
-0.040134475,
-0.010495908,
0.004170365,
0.0016570772,
0.007839375,
-0.018504571,
-0.027008079,
-0.030992879,
-0.022880036,
0.0095322635,
-0.01438955,
0.026669502,
0.022632614,
-0.0061822976,
0.01509275,
-0.004069443,
-0.16210057,
0.0067975977,
0.011674418,
-0.006436231,
0.034743275,
-0.0049451874,
0.016694482,
-0.015275061,
0.003003249,
-0.0094411075,
0.019064527,
0.006100909,
-0.03359732,
-0.0114725735,
-0.009362974,
0.014415595,
-0.016407995,
0.02560168,
0.009558308,
0.0041898987,
0.030862655,
-0.026396034,
0.011374907,
0.00021039021,
0.0010116636,
0.012631551,
0.007878441,
0.0032132322,
-0.017449772,
-0.004831243,
-0.012032529,
-0.014259328,
0.038780164,
0.021642925,
0.008210508,
0.013165462,
0.020002127,
-0.01820506,
-0.010508929,
-0.01937706,
-0.006039053,
0.02178617,
0.013491018,
0.0033336878,
0.014037951,
0.0119804405,
0.023205591,
-0.0016456827,
-0.0015162744,
-0.0024139937,
0.009030908,
0.0038122542,
-0.003441121,
0.00962993,
0.02459897,
-0.004915887,
0.019937016,
0.019207772,
-0.010658685,
-0.0329983,
-0.0037178432,
-0.02360928,
0.010294063,
0.01890826,
0.026122568,
-0.026877858,
0.008223531,
-0.01621266,
-0.03216488,
0.0041019986,
-0.041176252,
-0.004427554,
0.025237057,
-0.012664107,
0.028206123,
-0.008724886,
-0.007832864,
0.022098703,
-0.006641331,
-0.004769387,
-0.018413415,
-0.00080615666,
-0.020705326,
-0.03094079,
-0.009063464,
0.00851002,
0.030419901,
0.0010295691,
0.0060130088,
-0.02454688,
-0.0062148534,
-0.028075902,
0.025145901,
-0.021590836,
0.012878973,
0.029638568,
0.005013554,
0.009753641,
-0.026565325,
0.010854019,
0.006319031,
-0.0074421973,
-0.015222972,
0.0155355055,
0.030263634,
-0.013438929,
-0.02379159,
0.014376529,
0.041540876,
-0.01021593,
-0.00669342,
0.014936483,
0.0028176825,
0.04185341,
0.0058990647,
0.01409004,
-0.0035127432,
-0.011029818,
0.008783486,
0.007227331,
0.054953758,
-0.00011689475,
-0.0031448656,
0.012175773,
0.008080286,
-0.014207239,
-0.12563835,
-0.02272377,
-0.014780217,
0.018530617,
0.005778609,
-0.009089508,
0.0021242492,
0.03146168,
-0.0072077974,
0.026278835,
-0.008223531,
-0.009239264,
0.0020607659,
-0.004010843,
0.0069082864,
-0.0068887533,
0.014676039,
0.0111925965,
-0.031071011,
0.0332327,
0.0073249973,
0.0050623873,
-0.017072128,
-0.022450304,
0.008034708,
-0.0025230546,
-0.024625013,
0.016421016,
0.0032474154,
0.023817636,
-0.010183374,
-0.00088388304,
0.012963617,
0.0036104098,
0.005684198,
-0.0043949983,
0.007416153,
-0.014454662,
0.0358111,
-0.016889816,
-0.0012338551,
-0.0009913163,
0.013373817,
0.015769906,
0.017319549,
0.0013575662,
-0.025731903,
0.016564261,
0.018192038,
-0.0018686883,
-0.035264164,
-0.002096577,
-0.032269057,
-0.00083749136,
-0.0011508384,
-0.022502393,
0.00839933,
0.027138302,
-0.031279366,
-0.010665196,
-0.00300976,
-0.00330276,
0.007989131,
0.022437282,
0.030341767,
-0.00692782,
-0.035915278,
-0.033310834,
0.011361885,
-0.04128043,
-0.012605507,
0.004938676,
-0.0101312855,
-0.009402041,
-0.032216966,
0.029690657,
-0.00013673329,
-0.010508929,
0.00021893604,
-0.018400393,
-0.0054693315,
0.000017574906,
0.025536569,
-0.011342351,
0.006680398,
0.01767115,
0.010938663,
0.0059804535,
-0.010228952,
-0.0057655866,
-0.0004903679,
0.020679282,
-0.0046456764,
-0.011088419,
-0.0046554427,
-0.0017547439,
-0.0033336878,
-0.013660306,
0.01591315,
0.015170883,
-0.012729217,
-0.03588923,
-0.037451897,
0.026448123,
-0.00957133,
-0.009076485,
0.011954396,
0.008672797,
0.019585416,
0.003279971,
0.028258212,
0.017137239,
0.008789997,
0.005267487,
0.022645637,
-0.010469863,
-0.021330392,
-0.018465504,
0.019116616,
0.008549086,
0.0021128547,
0.032373235,
-0.006553431,
0.016655417,
0.00046147485,
0.05255767,
-0.0026923434,
-0.0111014405,
-0.017957639,
0.030524079,
-0.031435635,
-0.033623368,
0.0041833874,
-0.026057458,
-0.0069017755,
-0.0021177381,
-0.017475815,
-0.020939726,
-0.014689062,
0.014063995,
0.013764484,
0.061152335,
0.000986433,
-0.02953439,
-0.012872462,
-0.004391743,
0.012690151,
-0.002864888,
-0.027997768,
0.008047731,
-0.009499708,
-0.011602796,
0.039665677,
0.013217551,
-0.02911768,
-0.021004837,
-0.014050973,
0.030081322,
0.003411821,
0.009460641,
-0.013100351,
-0.0013396606,
0.035706922,
-0.018335283,
-0.0022756325,
0.009649463,
0.0027232713,
-0.008197486,
-0.019637505,
-0.00962993,
0.008581641,
-0.022684703,
-0.012403662,
0.01315244,
0.011667907,
0.011238174,
0.017124217,
-0.0099033965,
-0.012006485,
0.010886574,
0.004157343,
0.015835017,
0.0022333104,
0.009447619,
-0.03318061,
0.00059373176,
0.020601148,
-0.020483948,
-0.0012883857,
0.03500372,
-0.004531732,
-0.008666286,
-0.0052967872,
0.01280084,
0.004515454,
0.013171973,
0.01509275,
0.011231663,
0.0030553378,
-0.010254997,
0.006778064,
0.027607102,
0.010600085,
0.00018485445,
-0.01673355,
-0.03633199,
-0.0044438317,
0.020744393,
-0.046072606,
-0.034560967,
-0.018725948,
-0.013829595,
0.00029137213,
0.008327709,
-0.014910439,
0.008288641,
-0.0125338845,
-0.0023602769,
-0.0077482197,
-0.0021405271,
0.012898507,
0.0020347214,
0.02695599,
0.011440018,
0.0061855535,
0.007924019,
0.006211598,
0.013412884,
0.023739502,
-0.027528968,
0.009148108,
-0.010209419,
0.02019746,
0.01708515,
-0.038597852,
-0.0024302714,
0.00572652,
-0.04464016,
0.0023879493,
0.010476374,
-0.010886574,
0.07011162,
-0.007793797,
-0.0055214204,
0.0039261985,
-0.0077547305,
0.018387372,
-0.0010474747,
0.012169262,
-0.011615818,
0.0036006432,
0.02771128,
-0.030524079,
0.017215371,
-0.03617572,
-0.014311417,
0.02695599,
-0.0059218532,
0.03430052,
0.018504571,
-0.02489848,
0.03687892,
0.0010596829,
0.010632641,
0.023635324,
-0.019884927,
0.00015677529,
0.042712875,
0.000114758295,
-0.011068885,
-0.007246864,
0.017059105,
-0.026695546,
-0.037425853,
-0.0027721047,
0.016525194,
-0.038728077,
0.005013554,
-0.00075366086,
0.022398215,
0.010209419,
-0.013106862,
-0.00070767617,
-0.014077017,
-0.018257149,
-0.012716196,
-0.01679866,
0.00437221,
-0.01843946,
-0.05185447
] |
Interfering with the activity of polo-like kinases can lead to the formation of monopolar spindles. Polo-like kinases also regulate mitotic entry, activation of the anaphase-promoting complex and the necessary preconditions for cytokinesis. Similarities between the phenotypes of the Drosophila mutants asp and polo point towards a common role in spindle pole function. The abnormal spindles of asp mutants are bipolar but have disorganized broad poles at which γ-tubulin has an abnormal distribution. Moreover, the synergism or of polo1 aspE3 double mutants indicates a possible involvement of these | [
-0.040172946,
0.00778471,
0.0081142215,
-0.029051932,
-0.055879664,
0.039486464,
-0.02253035,
0.013455054,
-0.011862415,
-0.034296658,
0.024960497,
-0.0008212045,
0.011436796,
0.021967435,
-0.009871616,
0.023532614,
0.023024617,
-0.0003711295,
-0.016091146,
0.024013152,
-0.017573947,
0.041545913,
0.0037550584,
-0.036383566,
0.008732055,
0.0038202743,
-0.00066803314,
-0.01905675,
-0.022173379,
-0.016791359,
0.010667936,
-0.009164539,
0.014924126,
0.00023147327,
0.002167568,
-0.0114779845,
0.02523509,
-0.01826043,
0.0065181497,
-0.004661215,
0.017052222,
-0.0014270252,
-0.014306292,
-0.0005817938,
-0.017532758,
0.016612872,
0.010853286,
0.0013506539,
-0.0017204963,
0.019317612,
0.0028489018,
0.012061494,
-0.029024472,
-0.009542105,
0.001509403,
-0.012947056,
0.028228154,
-0.013441324,
-0.019317612,
0.0038340038,
-0.009384214,
0.0009155958,
-0.007777845,
0.02294224,
-0.025880383,
0.018864535,
0.009068431,
0.008972324,
-0.009445997,
-0.006779013,
0.051870607,
0.0288048,
-0.0072973073,
-0.023491425,
0.013070623,
-0.029491281,
-0.017601406,
0.007111957,
-0.01320792,
0.019605935,
0.027267078,
-0.0067996075,
-0.002859199,
0.01556942,
0.016475577,
-0.0075581707,
0.011725118,
0.025990222,
0.009864751,
0.010915069,
0.0022053246,
0.038223337,
0.035916757,
0.019688314,
-0.016599143,
-0.0064666634,
0.0026652676,
0.022022353,
-0.02178895,
-0.016448116,
0.0035285193,
0.006425475,
-0.018740967,
-0.015281097,
-0.025907844,
0.014525966,
0.011519173,
-0.013001976,
0.01710714,
-0.008807569,
-0.015061422,
0.008093627,
0.01865859,
-0.046818096,
0.023079537,
-0.007256118,
0.0009113053,
0.00448273,
-0.02130841,
-0.00070493156,
0.026511949,
0.047669332,
0.00660396,
-0.008333895,
0.02839291,
-0.0029038202,
-0.0007195193,
0.029765874,
-0.0333905,
-0.0029415768,
0.01629709,
0.010963123,
0.004475865,
0.0045891344,
-0.018054485,
-0.015844012,
-0.01669525,
-0.029408904,
-0.026662974,
-0.025029145,
0.015212448,
0.026800271,
-0.015816553,
0.004616594,
0.017189518,
0.00408457,
0.019248964,
-0.00041060225,
0.00078387704,
0.003851166,
0.008979189,
-0.004177245,
0.018027026,
-0.0053271027,
-0.0103041,
0.0240818,
-0.0035456812,
0.024823202,
-0.027363187,
-0.019743232,
-0.015459582,
-0.010249182,
0.00087226165,
-0.004019354,
0.031825323,
0.03149581,
-0.0104070725,
0.018933183,
0.0035130733,
-0.018878264,
0.005028483,
0.0005856552,
-0.039980732,
0.0111416085,
-0.013832619,
0.002268824,
-0.006188638,
0.027829994,
-0.013427595,
-0.006943769,
-0.017656326,
0.011539768,
0.020100202,
0.008780109,
-0.00261893,
-0.0023820938,
0.008038708,
-0.0074826577,
0.0015608892,
0.0022705402,
-0.008251518,
0.003236764,
0.0057595866,
-0.009047837,
-0.62695056,
-0.024644716,
0.01070226,
-0.027102323,
0.018068215,
0.029656038,
0.0030737247,
-0.013482513,
-0.015088881,
0.0086359475,
-0.021006359,
0.02218711,
0.014210184,
-0.02294224,
-0.027775075,
-0.02839291,
0.0043454333,
-0.014429859,
0.028557666,
0.005718398,
-0.02021004,
-0.0033671958,
-0.0091851335,
0.018370267,
0.0078396285,
0.00007889184,
0.037811447,
-0.004692107,
-0.021706572,
0.036328644,
-0.024040611,
0.010825827,
-0.0070570386,
0.0049975915,
0.042452067,
-0.0026292272,
-0.0017041924,
0.028475286,
0.011759442,
0.052392334,
-0.016983572,
0.035944216,
0.021555545,
-0.003792815,
0.0069746603,
0.008004384,
-0.0075719003,
-0.008471192,
0.002958739,
-0.0031286431,
-0.009775508,
0.014965315,
-0.02675908,
-0.0023477697,
0.00029668908,
0.021363331,
0.015377204,
-0.017162059,
-0.009288106,
0.03377493,
-0.0155419605,
0.0050456454,
-0.03111138,
-0.025303738,
-0.006027315,
-0.0011361283,
-0.009617617,
0.0015823417,
-0.011402472,
0.00037155856,
0.022969699,
0.022063542,
-0.02294224,
-0.0016801655,
-0.008285842,
0.032429427,
-0.0075169816,
0.01598131,
-0.0058556944,
0.020457173,
0.0019049884,
-0.0041085966,
-0.028200695,
-0.002325459,
0.032319587,
0.012404736,
-0.0069403364,
0.030397438,
-0.018603671,
0.005086834,
0.013118678,
-0.008059302,
-0.00949405,
-0.030891705,
-0.033912227,
0.02995809,
-0.025935303,
0.007050174,
0.0060479096,
-0.034736007,
-0.0069163097,
-0.0021727167,
-0.02446623,
-0.005285914,
0.011244581,
0.016654061,
-0.023985693,
0.0033654796,
0.023175644,
-0.030260142,
0.0061989357,
-0.01902929,
-0.003010225,
-0.01437494,
0.027610319,
-0.020457173,
0.01863113,
-0.005069672,
-0.00630534,
-0.008457462,
-0.013496242,
-0.0004058827,
0.012878409,
-0.0062160976,
0.0012193642,
0.013214785,
0.00042390285,
-0.0137708355,
0.0068236343,
-0.011608416,
-0.0035422489,
-0.0017814217,
0.034104444,
-0.025839195,
0.017422922,
0.010544369,
0.0110180415,
0.01399051,
0.03492822,
-0.030424897,
-0.031029,
-0.017642597,
-0.0042733527,
0.002517674,
0.01710714,
-0.019702043,
-0.034076985,
0.0034427089,
0.0099196695,
0.008018114,
0.001217648,
-0.008876217,
-0.012933327,
0.008889946,
0.01675017,
-0.0050044563,
-0.025056606,
-0.0143200215,
0.007276713,
-0.024260286,
0.005859127,
-0.012322358,
-0.016008768,
0.015404664,
-0.00949405,
-0.02291478,
0.015816553,
-0.020567011,
-0.010839556,
-0.030562194,
-0.0024147015,
-0.012198791,
-0.027143512,
-0.0012614114,
-0.029271606,
0.03770161,
-0.007908276,
-0.0074071446,
-0.005975829,
0.005128023,
-0.015377204,
-0.0116907945,
-0.017601406,
-0.017779892,
0.029408904,
0.013166731,
0.032072455,
0.015432123,
0.0055467775,
0.03262164,
-0.020415984,
0.029189229,
0.014745641,
0.0062744487,
-0.004692107,
-0.011622146,
0.0031972914,
0.02995809,
-0.022489162,
0.028283073,
0.011182797,
-0.032731477,
0.0031252108,
-0.0065318793,
0.011677065,
-0.037097506,
0.0005985268,
-0.033472877,
-0.007503252,
0.0137708355,
-0.010084425,
0.010564963,
-0.0071394164,
-0.0016278212,
0.011375012,
-0.005828235,
-0.012075224,
-0.005502156,
0.0018123133,
0.00775725,
-0.01596758,
0.011093555,
0.011937927,
0.0031303593,
0.00028639185,
0.011127879,
0.01087388,
0.030177763,
0.006027315,
0.003425547,
0.0026961593,
0.015349745,
-0.002325459,
0.00990594,
0.0036246267,
0.0202375,
0.010997447,
-0.006645149,
0.06134406,
-0.011519173,
0.013599215,
0.02015512,
-0.007379685,
-0.01205463,
-0.0021195142,
-0.004067408,
0.037042588,
0.014635803,
0.0020560145,
0.020333607,
0.0020869062,
-0.0040914346,
-0.010262911,
-0.02016885,
0.005361427,
-0.0048362683,
-0.0028489018,
0.016214713,
0.026800271,
0.025894113,
-0.005416346,
-0.031248676,
0.010619882,
-0.009555834,
-0.0053408328,
-0.0120271705,
-0.0069060125,
0.008436868,
-0.022612728,
-0.007352226,
-0.026690433,
0.01941372,
0.021651654,
-0.013468783,
0.015734175,
0.008972324,
0.0032899666,
0.031303596,
0.01360608,
0.018411456,
-0.011217121,
-0.042040177,
0.02833799,
0.015075152,
-0.012727383,
-0.015775364,
-0.014649533,
0.00350106,
0.006700068,
0.019221505,
0.004887754,
-0.0098578865,
0.009411673,
0.005992991,
-0.005776749,
-0.028997013,
0.009095891,
-0.022173379,
0.026209896,
-0.0012476817,
-0.008526111,
0.011972252,
-0.023518885,
0.0042150016,
0.033308122,
0.021198574,
-0.0006521582,
-0.020676848,
-0.009960859,
-0.0458021,
0.0059037483,
-0.020072743,
-0.0031046164,
0.007331631,
-0.03234705,
-0.0091233505,
0.014992774,
0.00034238308,
0.026951296,
-0.007853358,
-0.017670056,
-0.019605935,
-0.007105092,
0.004328271,
0.020059014,
0.037427016,
0.009960859,
0.02487812,
-0.0019410287,
0.011979117,
-0.0045136213,
-0.015500771,
0.03772907,
-0.0061096926,
-0.009294971,
-0.015651798,
-0.006545609,
0.003936976,
0.011677065,
0.013262839,
-0.011258311,
-0.023807207,
0.003593735,
0.011237716,
-0.0019444613,
0.0006234118,
0.022475433,
0.03289623,
0.011532904,
0.009809833,
-0.0083613545,
0.02990317,
-0.013221649,
-0.024315204,
-0.01555569,
-0.0010134196,
0.018232971,
0.013612945,
-0.005917478,
-0.04160083,
-0.003477033,
0.037591774,
0.012418466,
0.005035348,
0.016983572,
0.011807497,
-0.0026549704,
0.0008606772,
-0.0030891704,
-0.003693275,
0.0047332956,
-0.0012648437,
-0.017532758,
-0.010530639,
0.02675908,
-0.033280663,
0.013214785,
-0.015418394,
0.020347336,
-0.0072973073,
0.005103996,
-0.019853069,
-0.020361066,
-0.0015420109,
0.0016046525,
-0.014553426,
-0.005896883,
0.010990582,
0.0044381083,
-0.0062641515,
-0.006192071,
-0.020745495,
-0.0237111,
-0.029463822,
0.014512236,
-0.03385731,
-0.02800848,
-0.021898787,
0.018946912,
0.027527941,
0.003954138,
-0.019880528,
-0.0030891704,
0.028118316,
0.004784782,
-0.01941372,
-0.0061646113,
-0.031578187,
-0.0056016957,
0.016077416,
0.014292562,
-0.0016278212,
-0.02095144,
0.005828235,
-0.0028540504,
0.0012099252,
-0.0019101371,
-0.022983428,
-0.0026206463,
0.012459654,
0.010709125,
0.048108682,
-0.0028454694,
0.0035216543,
-0.0052721845,
-0.048767705,
-0.028035939,
-0.03698767,
-0.02213219,
-0.010551234,
-0.0072492533,
0.0033088448,
-0.0028454694,
0.0033122774,
-0.0030136574,
-0.0054781293,
0.002843753,
0.0145946145,
0.023532614,
0.017340545,
0.002567444,
0.01669525,
0.0003960145,
-0.01710714,
-0.013846349,
-0.004026219,
0.015624338,
-0.0017376584,
-0.016914925,
0.021157386,
0.014429859,
-0.02526255,
-0.022502892,
0.0032196022,
-0.012185061,
0.021157386,
-0.0021401087,
-0.04003565,
-0.01128577,
0.024287745,
-0.009603888,
0.0035594108,
0.012020306,
0.0013815457,
-0.0009010081,
0.002902104,
-0.007496387,
-0.016008768,
0.025990222,
-0.034049522,
-0.019180316,
0.021830138,
-0.0075169816,
0.01168393,
0.0046886746,
0.0019427451,
0.00040716983,
-0.0005599122,
-0.0071737403,
-0.049481645,
-0.0056291553,
-0.025358658,
0.036411025,
0.033253204,
0.030946624,
0.0025640116,
0.010832692,
0.006398015,
0.007036444,
-0.0076680076,
-0.0028866583,
0.010674801,
-0.022049813,
0.016461847,
0.01790346,
0.01669525,
0.020031555,
-0.015651798,
0.026635515,
0.031331055,
-0.030836787,
-0.018342808,
0.017258165,
-0.024699634,
-0.018507564,
0.019756962,
-0.014704452,
-0.0119653875,
-0.037042588,
0.002193311,
0.005255022,
0.011958523,
-0.0186174,
-0.015322286,
0.014896667,
-0.022159649,
0.05903748,
-0.021102468,
0.018164322,
-0.011663334,
-0.023038346,
-0.003634924,
-0.0056222905,
0.01907048,
-0.0050731045,
0.013832619,
-0.00020755365,
-0.0017900027,
0.010015777,
0.023120726,
-0.015130071,
-0.001009129,
-0.018603671,
-0.04467627,
-0.0016612873,
-0.026745351,
-0.0012845801,
-0.043385684,
0.00013686741,
0.007729791,
-0.023779748,
0.002666984,
-0.005333968,
-0.03267656,
0.02913431,
-0.0011953374,
0.02487812,
-0.016612872,
0.007661143,
0.0056978036,
-0.005756154,
0.007311037,
-0.023175644,
-0.01830162,
0.004970132,
0.023175644,
0.03111138,
-0.023381589,
-0.014038564,
-0.0025331199,
-0.010784637,
-0.013715917,
-0.030809328,
-0.006926607,
-0.014814289,
0.03069949,
-0.0027527942,
0.008100492,
-0.011265175,
0.022612728,
-0.021981165,
0.005103996,
0.0018740968,
-0.029271606,
-0.0061680437,
0.008958595,
-0.003042833,
0.028859718,
-0.008182869,
-0.013640404,
0.011402472,
-0.016777629,
0.018013297,
0.017628867,
0.0007383976,
0.036767993,
-0.010461991,
0.012178197,
-0.0013583769,
0.027267078,
0.002551998,
-0.014443588,
-0.013365811,
0.044127084,
-0.01826043,
0.01828789,
-0.00018105972,
-0.016571684,
0.010022642,
-0.005303076,
0.010592422,
-0.00013590205,
-0.016146064,
0.0070982273,
0.032319587,
-0.0143200215,
0.006830499,
-0.0028815097,
-0.028200695,
-0.0039678677,
0.0035559784,
-0.022008624,
-0.0062710163,
-0.046186533,
-0.01221252,
-0.012988246,
0.0137777,
0.0029947793,
0.01981188,
0.0032007238,
-0.010510044,
0.030397438,
-0.017175788,
0.0038580308,
-0.0101942625,
0.00025120963,
-0.048081223,
0.004777917,
0.0034186821,
-0.011134744,
0.00543694,
-0.00553648,
-0.02409553,
0.006775581,
-0.00775725,
0.009349889,
0.0058351,
-0.010908204,
0.016887465,
0.012246845,
0.011553498,
-0.0032041564,
-0.032292128,
-0.006796175,
-0.031385973,
-0.006037612,
0.00095850095,
-0.016832547,
-0.03921187,
-0.019976636,
-0.012377276,
-0.004887754,
-0.02015512,
-0.005670344,
-0.020663118,
-0.02836545,
-0.004043381,
0.020470904,
0.014155266,
-0.022859862,
-0.020772956,
0.013812025,
0.02759659,
0.013118678,
-0.011340688,
-0.0031715485,
-0.00033487467,
0.020113932,
-0.021871326,
-0.0020062446,
0.016640332,
-0.030397438,
-0.039376628,
0.0012914449,
-0.012473384,
0.041875422,
0.015432123,
-0.025509683,
-0.006779013,
0.009624482,
-0.018054485,
-0.023079537,
-0.0023185941,
-0.0067584184,
0.010613017,
0.020457173,
0.007235524,
-0.0013987077,
0.0047573224,
0.00034066685,
-0.008148545,
-0.018178053,
-0.0037619232,
-0.008800703,
0.009851022,
-0.016914925,
-0.028447827,
0.0027236186,
0.027733887,
-0.018232971,
-0.010441396,
0.03111138,
-0.005292779,
-0.008931135,
-0.006710365,
0.01048945,
0.008237788,
0.020663118,
0.0063499617,
-0.034296658,
-0.020333607,
0.006545609,
0.030781869,
-0.015583149,
0.0148692075,
-0.0007731507,
-0.014567155,
0.01185555,
-0.02990317,
-0.021061279,
0.0054643992,
-0.006425475,
0.031797864,
0.021692842,
0.024795743,
0.003444425,
0.0013429311,
0.009329295,
-0.025495954,
-0.009480321,
-0.015802823,
-0.0030823057,
0.015212448,
0.010015777,
0.020319877,
0.008285842,
-0.0086634075,
-0.006634852,
-0.017999567,
-0.0055055884,
0.026374651,
-0.035038058,
0.033967145,
-0.0012914449,
-0.0017882865,
-0.008038708,
0.005745857,
0.00031835618,
-0.0065730684,
0.0109287985,
-0.0034959114,
-0.0021246627,
0.012109549,
-0.019551016,
-0.014567155,
0.016448116,
-0.021679113,
-0.009761779,
-0.02762405,
0.031166298,
0.18826091,
0.0048156735,
-0.0010365883,
0.013956186,
-0.0075581707,
-0.008375085,
0.01379143,
-0.014718181,
-0.023381589,
0.0072835777,
0.02221457,
-0.012500843,
-0.0036452212,
0.00036705352,
0.043001253,
0.0059071807,
-0.011944792,
-0.012562627,
-0.010606152,
-0.015761634,
0.022502892,
-0.02328548,
0.024836931,
0.012727383,
0.028173234,
0.0041875425,
-0.03380239,
-0.011594687,
-0.014127807,
0.015281097,
-0.027445564,
0.0063739885,
0.0138600785,
-0.0020937712,
0.00855357,
-0.00476762,
-0.010235452,
-0.0063739885,
0.012171332,
0.004060543,
-0.0025794574,
-0.0048671598,
0.010153074,
-0.0002316878,
-0.0041841096,
0.004510189,
0.0051829414,
-0.010647341,
0.006919742,
0.02799475,
-0.0652982,
0.023532614,
0.02327175,
0.01746411,
-0.0023649316,
-0.004252758,
0.027019944,
0.007681737,
-0.0021727167,
0.03311591,
-0.0050250506,
0.020718036,
-0.020004096,
0.0061199903,
-0.016585413,
0.012294899,
-0.0035628434,
0.023505155,
-0.0012296615,
-0.020649388,
-0.0026309437,
-0.014278833,
-0.011649605,
0.0004710985,
-0.000291755,
-0.020429714,
0.024836931,
0.017450381,
0.022695106,
0.019743232,
-0.008121086,
0.006336232,
-0.03146835,
-0.0012725666,
0.008251518,
-0.01105923,
0.03962376,
0.005831667,
-0.015692987,
-0.004153218,
0.004132624,
-0.026003951,
-0.0016046525,
0.003576573,
0.00261893,
-0.018054485,
0.0045445133,
0.0028969555,
-0.02798102,
-0.030809328,
-0.01598131,
0.064803936,
0.018946912,
-0.006947201,
-0.0081142215,
0.006662311,
0.010544369,
-0.007928871,
0.008148545,
-0.028035939,
0.023244292,
-0.018219242,
0.010976853,
-0.008306436,
-0.012967652,
-0.0014193022,
0.035312653,
-0.029381445,
0.025811736,
0.00251939,
-0.007194335,
-0.024740823,
0.008258383,
0.024370123,
-0.013832619,
0.0011979117,
-0.023065807,
0.0050559426,
-0.012830355,
-0.0063568265,
-0.0019547585,
-0.018013297,
-0.005756154,
0.008684002,
-0.014608344,
-0.0151438005,
0.0063087726,
-0.021830138,
0.016640332,
-0.02022377,
0.00036061776,
0.0047882143,
0.017065952,
0.014443588,
-0.00024241407,
-0.01552823,
0.0048808893,
0.02839291,
-0.024411311,
-0.014443588,
0.00014201604,
0.0018775292,
-0.009102756,
-0.0050319154,
0.008203464,
-0.030836787,
-0.008642812,
-0.022283217,
-0.0028386044,
0.021514356,
-0.021500627,
0.019262694,
0.0056566144,
-0.0097343195,
0.0062641515,
-0.008807569,
-0.17442143,
0.005687506,
0.013674729,
-0.010818962,
0.02839291,
0.024919309,
0.013757106,
-0.024713363,
0.0031784133,
-0.010674801,
0.013784565,
0.025042875,
-0.032566722,
-0.037124965,
0.020004096,
0.008821298,
-0.0008636806,
0.02604514,
0.032566722,
0.019866798,
0.0202375,
-0.04234223,
0.0069060125,
-0.0076336837,
-0.008677137,
0.024191638,
-0.005035348,
-0.010036372,
0.0037790854,
-0.032044996,
-0.0079426,
0.021198574,
0.008265248,
-0.0030582787,
0.024232827,
-0.008031843,
-0.008478057,
-0.011505444,
0.0059140455,
0.02568817,
0.021830138,
0.016873736,
0.010125615,
-0.018850805,
0.0108052315,
0.046186533,
-0.009226322,
0.0038648956,
-0.0044587026,
-0.014745641,
0.039074574,
-0.010345289,
0.026127517,
0.01749157,
0.030946624,
0.0021864462,
0.0109562585,
0.023573803,
-0.0076336837,
0.00775725,
0.0075169816,
-0.023779748,
0.0233404,
-0.011175932,
0.0086359475,
-0.021583004,
-0.008430003,
0.024782013,
-0.035587244,
0.009054702,
-0.009075296,
0.025015416,
0.025386117,
-0.021994894,
0.029820792,
-0.00009390864,
0.0011489998,
0.015747905,
0.0054781293,
-0.002759659,
-0.026690433,
0.025303738,
-0.010276641,
-0.02527628,
0.001626105,
0.030644571,
-0.014676993,
0.030095385,
-0.0017282193,
-0.0045925668,
0.0055399123,
-0.035889298,
-0.0070639034,
-0.0057218303,
0.029024472,
0.032978613,
-0.015184989,
-0.017876,
0.0030788733,
0.0030462653,
-0.0027030243,
0.0148692075,
-0.013132407,
0.025495954,
0.030397438,
0.0040639755,
-0.004228731,
0.013942456,
0.0428365,
-0.006761851,
0.011484849,
0.005114293,
-0.0036246267,
0.027418105,
-0.006322502,
0.03385731,
0.005333968,
0.016406927,
0.01784854,
-0.030781869,
0.066012144,
-0.023230562,
0.0009619334,
-0.006645149,
-0.0029329958,
-0.01783481,
-0.12180942,
-0.033747472,
0.020031555,
0.017944649,
-0.002859199,
-0.004595999,
0.0008889946,
0.035147894,
0.008134816,
0.039102033,
-0.025372388,
-0.020278689,
0.008443733,
0.0055536423,
-0.019880528,
-0.011539768,
0.0061989357,
-0.014553426,
-0.0031458053,
0.030589653,
-0.009576429,
-0.0007980357,
-0.011251446,
-0.013166731,
0.020539552,
-0.004328271,
-0.03220975,
0.022667646,
0.007922006,
0.0148692075,
-0.0046577826,
-0.004359163,
0.024850661,
-0.0009121634,
-0.028200695,
-0.020484634,
-0.0052035362,
-0.026676703,
0.026306003,
0.0119653875,
-0.005193239,
0.0069403364,
0.03311591,
0.0017642597,
0.022379324,
-0.009439132,
-0.019139128,
0.020347336,
0.0054575345,
0.001934164,
-0.026127517,
0.0005800776,
-0.0123017635,
-0.006761851,
0.00631907,
0.0005230137,
0.0074140094,
0.02722589,
0.0070844977,
0.01945491,
-0.0034392765,
0.01225371,
0.007976925,
0.00022417938,
0.015473312,
-0.006919742,
-0.015390934,
-0.05044272,
0.03687783,
-0.034433953,
-0.025880383,
0.012233115,
-0.020059014,
-0.012198791,
-0.01675017,
-0.0016630035,
-0.014333751,
-0.0143200215,
0.01791719,
-0.01595385,
-0.016255902,
-0.026278544,
0.015816553,
-0.020457173,
0.03495568,
0.0096725365,
0.023065807,
-0.020004096,
-0.00049812876,
0.0009730887,
-0.0073384964,
0.027829994,
-0.0031629673,
-0.031001542,
-0.032731477,
0.01864486,
0.004709269,
-0.005752722,
0.011031771,
0.025743088,
-0.029244147,
-0.022502892,
-0.053573083,
0.015583149,
0.012631275,
0.0024147015,
-0.0063396646,
-0.01747784,
0.018054485,
0.0012442493,
0.006360259,
0.012137008,
-0.015377204,
-0.0015076868,
-0.010667936,
-0.01945491,
-0.02877734,
-0.02913431,
0.027541671,
-0.032731477,
0.0039678677,
0.010221722,
-0.011443661,
0.0049598347,
0.02759659,
0.006452934,
-0.008416274,
-0.018850805,
-0.017381733,
0.026704162,
-0.004946105,
-0.0037996797,
0.007530711,
-0.024768284,
-0.014553426,
0.0022791214,
-0.009802967,
-0.024205368,
-0.0111416085,
0.026896378,
0.017738704,
0.03701513,
-0.015253638,
-0.021129927,
-0.002708173,
-0.017175788,
-0.0101324795,
0.019647125,
-0.01475937,
0.0048088087,
-0.004311109,
-0.017230706,
0.034379035,
0.00465435,
0.0052069686,
-0.036713075,
-0.016503036,
0.004462135,
0.00950778,
-0.0010099871,
0.0052893464,
-0.010420802,
0.010825827,
0.03566962,
0.003991895,
-0.010894475,
-0.020512093,
-0.0034718844,
-0.030781869,
-0.0055261827,
-0.014024834,
-0.044511516,
-0.030534735,
0.024603527,
0.01909794,
0.00028210133,
-0.007221794,
-0.0097343195,
-0.011924198,
-0.01865859,
0.0013858362,
0.00553648,
0.0070261466,
0.005886586,
-0.018329078,
0.011093555,
0.022379324,
-0.007819034,
0.0022396487,
0.036658157,
-0.006343097,
0.005660047,
-0.010056966,
0.017079681,
-0.009899075,
0.007860223,
0.008594759,
0.010544369,
-0.0040914346,
0.0019805015,
0.0039301114,
-0.0011163919,
-0.0039404086,
-0.01285095,
0.012480249,
-0.013441324,
-0.0016793074,
0.017230706,
-0.045500048,
-0.043385684,
0.001734226,
-0.022969699,
0.014580885,
0.0042493255,
0.011786901,
-0.00553648,
-0.008464327,
0.0021452573,
0.0011695942,
-0.0144024,
0.0084505975,
0.0045479457,
0.023203103,
0.03223721,
-0.010159939,
-0.0024953634,
0.01048945,
-0.010201127,
0.024260286,
-0.017876,
0.016063686,
-0.016393198,
0.039980732,
0.0017573948,
-0.04673572,
-0.024356393,
-0.0012442493,
-0.02137706,
0.0060444768,
-0.0015119774,
-0.0060067205,
0.09550342,
0.010084425,
-0.020786686,
0.015995039,
-0.028228154,
0.010262911,
-0.0046303235,
-0.0036829778,
-0.010207992,
-0.03956884,
0.032704018,
-0.020910252,
0.008196599,
-0.013317757,
-0.011759442,
0.013118678,
-0.014429859,
0.009377349,
-0.019303882,
-0.022873592,
0.01555569,
-0.028255614,
0.012459654,
0.046763178,
-0.02294224,
0.0040742727,
0.022283217,
0.014663262,
0.007111957,
-0.024397582,
0.011800631,
-0.015473312,
-0.042699203,
-0.022997158,
0.014429859,
-0.0076748724,
0.009253782,
-0.017601406,
0.029326525,
0.02059447,
-0.029189229,
-0.010214857,
0.0021246627,
-0.013544297,
0.012137008,
0.006343097,
0.026209896,
0.00067532697,
-0.026676703
] |
The paramount feature of long-term potentiation (LTP) as a memory mechanism is its characteristic persistence over time. Although the basic phenomenology of LTP persistence was established 30 years ago, new insights have emerged recently about the extent of LTP persistence and its regulation by activity and experience. Thus, it is now evident that LTP, at least in the dentate gyrus, can either be decremental, lasting from hours to weeks, or stable, lasting months or longer. Although mechanisms engaged during the induction of LTP regulate its subsequent persistence, the maintenance of LTP is also governed by activity patterns post-induction, whether | [
-0.008826644,
0.022367738,
0.04263729,
-0.03919211,
-0.02997044,
0.014777991,
0.01571052,
0.0016950653,
-0.020735813,
-0.023494544,
0.014544859,
0.040927652,
-0.01998461,
0.009616703,
0.0021338072,
-0.006113244,
0.03432224,
0.017044554,
0.008612939,
0.006294569,
-0.019298164,
-0.0013688421,
-0.0075703203,
-0.015671665,
0.01745901,
-0.0059740124,
0.011391098,
-0.02787225,
0.0037495429,
-0.0023183702,
0.01651353,
0.003552028,
-0.0078228805,
0.0024106517,
0.0035390763,
-0.026058998,
0.007576796,
-0.02093009,
0.027820442,
0.000024284604,
0.011967452,
0.017135216,
-0.006184479,
-0.0048633968,
-0.0052681398,
-0.018585816,
-0.0048536826,
-0.014622569,
-0.0013146065,
0.02526894,
-0.0036718321,
0.019065032,
0.0050511975,
-0.0034613656,
0.02506171,
-0.029996343,
0.005106243,
0.019621959,
0.019997561,
-0.038130064,
-0.0016367823,
0.005449465,
-0.0063237105,
-0.0061715273,
-0.0069745383,
0.015075882,
0.0019929565,
0.024504784,
0.030022245,
0.010121822,
0.011773176,
0.02288581,
0.0040765754,
0.006168289,
0.020580392,
-0.015555098,
0.001777633,
0.0034419377,
-0.012252392,
0.021538824,
0.00030214095,
-0.03170598,
-0.006411135,
0.048258364,
0.011468809,
0.0022940855,
0.023339123,
-0.012446669,
-0.0028299657,
0.010594563,
-0.011565947,
0.024103278,
0.03629091,
0.023209605,
0.017549673,
-0.00799773,
-0.016746663,
0.025100566,
-0.015943652,
-0.018002987,
-0.017718047,
-0.0049281553,
-0.016707808,
-0.01629335,
-0.041963793,
-0.008114295,
0.018495154,
-0.00037317342,
0.026706588,
0.0058283047,
-0.012135826,
0.03528067,
-0.0078099286,
-0.035721034,
-0.0096555585,
0.015904795,
-0.009409474,
-0.027328273,
0.010613991,
-0.015451483,
0.030540317,
0.0068838755,
0.021823764,
0.00009637952,
0.013780703,
0.0006220906,
0.017290637,
0.0062136203,
-0.0024122705,
0.01635811,
-0.0148557015,
0.017769855,
-0.025540927,
-0.016656,
-0.02940056,
0.0064661806,
0.0036297387,
-0.024712013,
-0.023909,
-0.020165935,
0.014829798,
0.005009104,
-0.025670445,
-0.00012577401,
0.000794916,
0.042145118,
-0.0028153951,
0.028001767,
-0.0061067683,
-0.0003090216,
0.0060873404,
-0.024971047,
-0.016902084,
0.021901473,
-0.016396964,
-0.0018553437,
0.019388827,
0.0044586533,
-0.022484304,
-0.0130942585,
0.007945922,
-0.010542756,
0.020813525,
0.0311361,
0.0127251325,
0.017640335,
0.005073863,
-0.015684616,
0.02194033,
-0.015801182,
-0.020127079,
0.019712621,
-0.0477921,
0.03411501,
-0.02578701,
0.012925885,
0.0014910747,
-0.00042579006,
-0.015956603,
-0.0056696455,
0.004270852,
-0.0031408088,
0.0051839533,
0.0045039845,
-0.02455659,
-0.018158408,
0.016086122,
-0.0038175397,
-0.0027279705,
0.0014182208,
-0.0008629129,
-0.0040182923,
-0.025294842,
-0.0065859845,
-0.644481,
-0.0029060575,
0.028105382,
-0.016021362,
0.010452094,
0.023701772,
-0.022380691,
-0.007958874,
-0.03854452,
0.026628878,
-0.014531907,
0.011747272,
0.021694245,
-0.0018521057,
-0.016733712,
-0.013664137,
-0.017627385,
0.006129434,
0.011028448,
0.012751035,
-0.0006046866,
0.0016918273,
-0.034814406,
0.03496983,
0.00354879,
0.009156914,
0.02433641,
-0.01263447,
-0.013152542,
0.030151764,
-0.0038045878,
0.009234625,
-0.0002416318,
-0.0042060935,
0.040746327,
-0.0013405101,
-0.016526483,
0.021551777,
-0.0014781229,
0.041523434,
-0.0126538975,
-0.010808268,
0.012615042,
0.013184921,
-0.0073242364,
-0.001007811,
-0.023857195,
-0.004967011,
0.001164042,
-0.03142104,
0.016176784,
-0.015956603,
-0.006200669,
0.005825067,
0.0074278507,
0.0037236393,
0.012071067,
-0.015542146,
-0.0038078257,
-0.0021176175,
0.008172578,
0.0016294969,
-0.0032023296,
0.013858413,
-0.02578701,
0.01162423,
-0.00033573463,
0.0126538975,
0.0060387715,
-0.011850886,
-0.0008098915,
0.033778265,
0.008593512,
-0.035461996,
0.0032929922,
-0.003613549,
0.017730998,
-0.0032023296,
0.019207502,
0.017005699,
-0.014946364,
0.006621602,
-0.032172244,
-0.0016027838,
0.031965014,
0.01506293,
-0.013962028,
0.009642607,
0.0042676143,
-0.0079070665,
0.009519565,
-0.0012927504,
-0.019298164,
-0.03209453,
-0.017277686,
0.025476169,
-0.014480099,
-0.0063560903,
0.0013971742,
-0.011501188,
-0.008308573,
0.011688989,
0.0096555585,
0.016863229,
0.034814406,
0.0035779316,
-0.012699229,
-0.004471605,
0.05548546,
-0.008697126,
0.025566831,
-0.013702992,
-0.007835832,
0.0022876097,
-0.019945754,
-0.02194033,
0.030721642,
-0.0125114275,
-0.013521668,
-0.017264735,
0.0110414,
0.004044196,
0.011365195,
-0.009985829,
0.0040895273,
0.03206863,
0.0029335802,
0.020140031,
0.003297849,
0.009649082,
0.01650058,
-0.005562793,
0.015697567,
-0.0015412628,
0.008839596,
0.02093009,
0.009487185,
-0.013534619,
0.02940056,
-0.026473455,
-0.0036653562,
0.010011733,
-0.025217133,
-0.015593953,
-0.03209453,
-0.016902084,
-0.015969556,
0.0028655832,
-0.011941549,
-0.01075646,
0.020904187,
-0.023986712,
-0.003998865,
0.01679847,
0.0035682176,
-0.0040182923,
-0.024168037,
-0.013534619,
-0.023688821,
-0.019816237,
-0.01470028,
0.0027927293,
-0.0224584,
0.03214634,
-0.0110478755,
-0.036601756,
0.008956161,
0.010277244,
0.007881164,
-0.045072224,
0.0017323017,
-0.0113457665,
0.009228149,
0.0035034588,
-0.004225521,
0.01650058,
-0.0035941212,
0.0006520416,
0.035306577,
-0.00035435284,
0.0024754105,
0.012388386,
-0.009869263,
-0.0049864384,
0.03064393,
-0.010685226,
0.013301487,
0.0006386851,
0.013871365,
0.017795756,
0.0015056455,
0.029633692,
-0.016319254,
-0.000013103568,
-0.015283111,
-0.0055336514,
0.010231913,
-0.0077257417,
0.005876874,
0.03585055,
0.01635811,
-0.022691533,
0.00214514,
-0.0022293266,
0.003555266,
-0.028882489,
0.0054267994,
-0.026862008,
0.01774395,
0.009856311,
-0.010193057,
-0.002940056,
0.0098822145,
-0.019233406,
-0.004481319,
0.046730053,
0.0036459283,
0.022147559,
-0.026395746,
-0.023585208,
0.028286707,
0.0019184836,
0.0018116314,
0.004183428,
-0.013806607,
0.029167427,
0.0047565443,
0.020696959,
-0.014894557,
-0.032327663,
-0.015904795,
0.010730557,
-0.006239524,
0.019803284,
0.015619857,
0.012945313,
-0.0033124199,
-0.016850276,
0.032224048,
0.023326172,
0.0070004417,
0.020761717,
0.010465045,
-0.008742457,
0.009014444,
0.0069874898,
0.014104498,
0.02482858,
-0.020178886,
0.0038175397,
-0.0083474275,
0.011753748,
-0.0013575093,
-0.0095843235,
-0.013599378,
-0.005151574,
0.010853599,
0.011902694,
0.013418053,
0.027069237,
-0.0053490885,
0.0076221274,
0.010102395,
-0.02411623,
-0.008703602,
-0.0063819936,
0.017873468,
-0.011410526,
-0.01433763,
-0.0021046656,
-0.022497257,
-0.0064661806,
0.0015105023,
-0.039062593,
0.019880995,
-0.020165935,
0.0055368897,
0.036368623,
-0.009422426,
0.0069097793,
-0.020036416,
-0.051392697,
0.022108704,
0.008315048,
-0.009260529,
-0.022290029,
-0.034451757,
-0.0028850108,
-0.0049411072,
-0.01766624,
0.0010434284,
0.0029659595,
-0.00858056,
-0.0060905786,
-0.016617145,
-0.0095130885,
0.025307795,
0.014829798,
0.0018456299,
-0.00040879083,
0.012368958,
0.022704486,
-0.015309014,
-0.0071364352,
0.014518955,
0.0020965708,
-0.019997561,
-0.017368348,
0.0111191105,
0.0048893,
0.012116398,
-0.013003596,
0.01897437,
-0.015490339,
0.035513803,
0.01716112,
0.016086122,
0.021538824,
0.043647528,
-0.0013413196,
-0.0070263455,
-0.005067387,
-0.0007220622,
-0.0029271042,
0.038699944,
0.020256598,
0.016992746,
0.022678582,
-0.01968672,
-0.024789723,
-0.0035261244,
-0.0049346313,
0.043984275,
-0.003067955,
-0.0065600807,
-0.0059740124,
0.008813692,
0.012006308,
0.0025855007,
0.013482812,
0.013858413,
-0.010510377,
0.013087782,
-0.023649966,
0.012148778,
0.015969556,
0.02036021,
0.043258972,
-0.012543807,
-0.022989424,
0.007971826,
0.009752696,
0.010860074,
-0.0016157356,
-0.008807216,
0.0010304766,
0.013651185,
0.0061715273,
-0.019142743,
-0.008748933,
0.009830408,
0.017847564,
0.01731654,
0.0019524822,
0.008567608,
0.009402999,
0.02693972,
0.012200585,
0.0133921495,
-0.0109766405,
0.01637106,
0.026253276,
-0.005818591,
-0.0013073211,
0.014298774,
-0.012427241,
-0.026810203,
-0.009435378,
0.021020753,
-0.01716112,
0.024893338,
0.0051710014,
0.007544417,
-0.009202246,
-0.020321356,
-0.04040958,
0.004144572,
-0.01241429,
-0.007945922,
0.003616787,
-0.0044845566,
0.007868212,
-0.005698787,
-0.018067745,
-0.023183702,
-0.0026664494,
-0.045305356,
0.009571372,
0.016902084,
0.020528585,
0.018870756,
-0.027354177,
-0.0068709236,
0.022691533,
-0.00793297,
-0.0021613296,
-0.016241543,
-0.01310721,
0.026447551,
0.011313387,
0.033286095,
-0.028701164,
-0.0018407729,
0.00089691137,
0.028338512,
-0.009182818,
0.027483694,
0.014052691,
-0.02722466,
-0.0076350793,
0.008677699,
0.026266227,
0.009856311,
-0.015179496,
0.0023539877,
-0.023637014,
-0.03388188,
-0.021733101,
0.002332941,
-0.0064726565,
0.0036685942,
0.0044975085,
0.0029594838,
-0.008865499,
0.015658712,
-0.012874078,
0.0018796283,
0.027690925,
0.014506003,
0.034296338,
0.00075403694,
0.005588697,
0.027820442,
-0.017187024,
-0.017044554,
-0.021564728,
0.0077386936,
-0.0058024013,
-0.005698787,
-0.005397658,
0.009804504,
0.015412629,
-0.022238221,
-0.011112634,
-0.012990644,
0.025372554,
0.015645761,
-0.015904795,
-0.016707808,
0.0055498416,
-0.023559304,
-0.00074877526,
0.006576271,
-0.005329661,
-0.022147559,
-0.004494271,
-0.0033156578,
-0.0030274806,
0.042689096,
-0.028234899,
-0.017782805,
0.004766258,
0.01745901,
-0.0022811338,
-0.0025563592,
0.00014823726,
-0.026602974,
0.003428986,
0.004967011,
-0.021396354,
-0.006530939,
-0.011682513,
0.007881164,
-0.0044295117,
0.026706588,
-0.0033350855,
-0.013204348,
0.012919409,
0.012362482,
-0.0045428397,
-0.009202246,
0.009590799,
-0.015412629,
0.009033873,
0.0022406594,
-0.005277854,
0.026499359,
-0.02179786,
0.014622569,
0.031835496,
0.011656609,
-0.01832678,
-0.015503291,
-0.021163223,
-0.02506171,
0.005873636,
0.0020528585,
-0.016189735,
-0.019906899,
-0.0056566936,
-0.0003652809,
0.0008499611,
0.0073177605,
-0.0022147559,
0.011527092,
-0.03180959,
0.028960198,
-0.008146675,
0.0002252397,
-0.012919409,
-0.019583104,
-0.02070991,
0.006181241,
-0.0037042114,
-0.005889826,
0.0095130885,
0.019388827,
0.0023216081,
-0.0074278507,
-0.029348753,
-0.030229473,
-1.6600804e-7,
-0.04815475,
-0.023377977,
-0.021759005,
0.010769412,
-0.013236728,
-0.008962638,
0.0042546624,
0.013495764,
-0.008269717,
0.046678245,
-0.026862008,
-0.02657707,
0.034788504,
0.00342251,
0.040280063,
0.002392843,
0.013256156,
0.014506003,
0.016306302,
-0.0069874898,
0.009221673,
0.0042093312,
0.0011753748,
0.031317424,
-0.020178886,
-0.019103888,
-0.021538824,
0.0024737916,
0.013625282,
-0.013184921,
-0.028960198,
0.014506003,
-0.019738525,
-0.013126638,
0.0017695382,
-0.005329661,
-0.01925931,
0.0076221274,
-0.018624673,
0.012874078,
0.012433717,
-0.013754799,
-0.009228149,
0.012181157,
0.0072724293,
0.0013656042,
-0.013806607,
-0.004691785,
-0.021668343,
0.003561742,
0.0017403966,
0.015762327,
-0.007537941,
0.038622234,
-0.0055336514,
0.009940498,
0.0109766405,
0.009500137,
-0.015736423,
-0.011850886,
-0.012763987,
0.03730115,
-0.026046047,
-0.028545741,
0.013048927,
0.0028688211,
-0.019738525,
-0.042974032,
-0.0131784445,
-0.028934296,
0.005507748,
0.013534619,
0.015283111,
0.000119298114,
-0.013767751,
-0.013223776,
-0.0111903455,
-0.007958874,
-0.011358718,
-0.0032071867,
0.014480099,
-0.03686079,
0.0065179877,
0.0021856143,
0.0069615864,
0.016409917,
-0.00847047,
-0.02627918,
-0.0124401925,
0.028545741,
-0.026810203,
0.028986102,
0.02375358,
0.01766624,
-0.025411408,
0.00085886545,
-0.007091104,
-0.012187633,
0.02309304,
-0.0116307065,
-0.033467423,
-0.004957297,
0.003252518,
0.025657494,
-0.025540927,
0.0062557138,
-0.0128805535,
-0.005041484,
0.0112292,
0.023442738,
-0.016966842,
-0.0001780871,
-0.0085611325,
-0.011805555,
0.008807216,
-0.058852926,
-0.013262631,
-0.008431614,
-0.009532516,
0.017420156,
-0.032975253,
0.024271652,
-0.028468031,
-0.006122958,
-0.04546078,
0.0073371883,
0.018637624,
-0.02411623,
-0.007816404,
0.013055403,
-0.010037636,
-0.0056146,
-0.009901642,
0.024893338,
-0.0033545133,
-0.0032751835,
-0.0033350855,
0.021163223,
0.017497865,
-0.027846346,
-0.023805387,
0.0034743173,
-0.027535502,
0.01832678,
-0.0059707747,
-0.003558504,
-0.004222283,
0.0030436702,
-0.042145118,
-0.015606905,
0.020036416,
0.011125586,
0.024375265,
0.01433763,
-0.022030992,
-0.009642607,
0.024168037,
0.026512312,
0.008528752,
0.002138664,
0.0045752195,
-0.031628266,
0.026836107,
0.011948025,
-0.021396354,
0.003055003,
0.022898762,
-0.021176174,
0.016047265,
0.0142599195,
-0.026110806,
0.009590799,
-0.0010215723,
0.014143353,
0.0025223608,
0.030669834,
-0.006122958,
-0.027846346,
0.027483694,
-0.005812115,
-0.001037762,
-0.029530078,
0.009454805,
0.00916339,
0.008541704,
0.03499573,
-0.005792687,
-0.019647863,
0.03484031,
-0.030255377,
0.041601144,
0.01890961,
-0.0013291773,
0.009564896,
0.010374382,
-0.010801791,
-0.04263729,
-0.01585299,
-0.022043943,
0.0026275942,
0.00810782,
-0.009603751,
0.02036021,
0.016254494,
0.016202688,
-0.040280063,
-0.0051191943,
0.00014955268,
0.0046237884,
-0.032042723,
0.023339123,
0.022199366,
-0.03199092,
-0.016021362,
-0.026240323,
0.0026049286,
0.0020609533,
-0.00085481803,
-0.017977083,
-0.020722862,
0.006067913,
0.014285822,
0.0053458507,
0.008004205,
-0.019466538,
-0.008697126,
0.006857972,
0.013910221,
0.18080696,
-0.016021362,
-0.0070652007,
0.016837325,
-0.0051094806,
0.004604361,
0.019997561,
-0.0016149262,
-0.011986881,
-0.00040373154,
0.028493935,
0.0051224325,
-0.030358993,
0.0018148693,
0.007401947,
-0.032483086,
-0.0065827463,
-0.009564896,
-0.013651185,
-0.0022390403,
0.026318034,
-0.016927987,
0.027794538,
0.017251782,
0.03206863,
-0.011054352,
-0.0154385315,
-0.006780261,
-0.0014894557,
0.0071364352,
-0.014285822,
-0.0045719813,
-0.007816404,
-0.011701941,
-0.020191839,
0.0009665272,
-0.0014740755,
-0.020230694,
0.010937786,
-0.010937786,
0.03553971,
0.014907508,
-0.006042009,
-0.02244545,
-0.001441696,
0.030669834,
-0.00054802257,
-0.012356007,
0.007084628,
0.0038758228,
-0.04136801,
-0.0007847974,
0.010950737,
0.015037026,
0.0038240156,
-0.00091633905,
-0.002998339,
0.019673767,
0.000214514,
0.016124977,
-0.0412903,
0.0072659533,
-0.02774273,
0.01599546,
0.001042619,
0.017394252,
-0.00238151,
0.016526483,
0.0009050062,
-0.007401947,
0.006297807,
-0.017536722,
-0.011591851,
0.0056307903,
-0.028701164,
-0.023468642,
0.0325867,
0.009571372,
0.015192448,
0.014130401,
0.00027279704,
0.0073760436,
-0.030669834,
0.0033901306,
-0.0004053505,
-0.012291247,
0.030203572,
-0.006242762,
-0.02201804,
0.0095130885,
0.0106075145,
0.0034063205,
-0.0099534495,
0.0012352768,
0.003856395,
-0.026913816,
0.018197263,
0.010458569,
-0.01774395,
-0.018210215,
-0.019000273,
0.06434449,
0.057609554,
0.01941473,
-0.0012789891,
-0.005213095,
-0.00057109294,
0.026525263,
0.0058347806,
-0.012647421,
0.025243036,
-0.02086533,
0.014208112,
-0.023041232,
-0.036912598,
-0.0058509703,
0.020114128,
0.0012668468,
0.028701164,
0.012122874,
-0.016332205,
-0.018805997,
0.002151616,
-0.0004403608,
0.0037819222,
-0.018508106,
-0.030825257,
0.0032071867,
-0.020023465,
-0.019932803,
0.015606905,
-0.014907508,
-0.0066377916,
-0.011242152,
-0.020878283,
-0.012420765,
-0.014467148,
-0.0014336011,
-0.008386283,
0.018417444,
-0.000103715494,
-0.021823764,
0.018028889,
0.011643657,
0.012627994,
-0.013664137,
-0.0097267935,
0.01925931,
-0.0042481865,
-0.011695465,
0.009461282,
-0.011313387,
-0.0038661088,
-0.004656168,
0.012200585,
-0.013923173,
-0.023352075,
-0.028727068,
-0.00825029,
-0.01897437,
-0.018443346,
-0.01223944,
-0.0058542085,
-0.009364143,
0.002820252,
0.0082632415,
-0.16091302,
0.009467757,
0.020010512,
-0.015386725,
-0.016448772,
0.016409917,
0.039218016,
-0.011993356,
-0.016422868,
0.023909,
0.014104498,
0.011805555,
-0.0340373,
-0.04165295,
0.0045687435,
0.0063301865,
0.01056866,
0.01839154,
0.007408423,
0.010594563,
-0.005002628,
-0.035513803,
0.02020479,
0.0025952146,
0.0027684448,
-0.0016570195,
0.027535502,
0.012077543,
-0.0020107653,
-0.0325867,
-0.021681294,
-0.0054591787,
0.013793655,
0.0038822987,
0.017782805,
0.0004440035,
0.0005391182,
-0.02585177,
-0.0009730031,
0.049216796,
0.016021362,
0.015542146,
0.000012831631,
-0.008897878,
0.011455857,
0.0038304913,
0.00916339,
-0.0145578105,
0.005423561,
0.004112193,
0.008463994,
-0.017834613,
-0.0031990916,
0.005332899,
0.018805997,
-0.0013672232,
0.0055304137,
0.010944261,
-0.008645318,
-0.0056502176,
-0.002266563,
-0.019246358,
0.012751035,
0.007771073,
0.008211434,
-0.040021025,
-0.0025417884,
-0.016578289,
-0.012194109,
0.011468809,
-0.013702992,
-0.01795118,
0.008315048,
-0.021875571,
0.023546351,
0.018585816,
-0.015049978,
-0.003979437,
0.008340952,
0.010523329,
-0.0061520995,
0.033337902,
-0.011688989,
-0.017536722,
-0.023468642,
0.0072724293,
0.0072530014,
0.020968946,
0.014169256,
-0.024168037,
0.011688989,
-0.027146949,
0.0011033305,
-0.0047274027,
0.020580392,
0.012958264,
-0.025022855,
0.014039739,
0.024595447,
0.0065082735,
0.006799689,
0.00799773,
-0.009428902,
0.0022390403,
0.01354757,
0.015218351,
-0.01998461,
0.012899981,
0.024284603,
-0.00036487618,
0.006773785,
0.00152993,
0.01651353,
0.0073307124,
0.012187633,
0.007039297,
-0.004231997,
-0.011973929,
0.010303148,
0.00477921,
0.059785455,
-0.023170749,
-0.009707365,
0.007142911,
-0.014402389,
-0.027535502,
-0.12951788,
-0.04742945,
0.005873636,
0.03064393,
-0.02085238,
0.0035228864,
0.0014198398,
0.0052487124,
0.00018344994,
0.024271652,
-0.0023377978,
-0.012569711,
0.020904187,
-0.022328883,
-0.0036783079,
-0.023015328,
0.022328883,
0.00043590865,
-0.039917413,
0.033363808,
-0.012615042,
-0.019855091,
0.0049929144,
-0.01744606,
0.009577848,
-0.01209697,
-0.015244255,
0.010711129,
0.004335611,
0.0033966065,
0.005093291,
0.0013793655,
0.008923782,
0.006352852,
0.009189294,
-0.016953891,
0.0036524043,
0.017057505,
0.042171024,
-0.0027457792,
-0.016720759,
0.0044295117,
0.03395959,
0.011306912,
0.00843809,
-0.03489212,
-0.02064515,
0.0145578105,
0.00012466096,
-0.017679192,
-0.022406595,
-0.008891403,
-0.018987322,
-0.008528752,
0.01201926,
-0.0024786484,
0.004348563,
0.0340373,
-0.013456908,
0.008140199,
-0.018793045,
0.002574168,
-0.016474675,
0.019013226,
0.04432102,
0.0030857637,
-0.023313219,
-0.05242884,
0.010672274,
-0.023326172,
0.007408423,
0.00793297,
-0.010413238,
0.0107499845,
-0.033622842,
0.02440117,
-0.018805997,
-0.029296946,
-0.0014530288,
0.0043129455,
-0.009189294,
-0.015632808,
-0.0040021027,
-0.040254157,
0.042559575,
0.010801791,
0.01288703,
0.008742457,
0.019427683,
0.0031278569,
-0.02997044,
0.022056896,
0.007162339,
-0.0142728705,
-0.010005256,
0.008444566,
-0.023857195,
0.004406846,
0.009849835,
0.024491832,
-0.007142911,
-0.014907508,
-0.029530078,
0.012291247,
0.011287483,
-0.006168289,
0.008697126,
0.008198482,
0.027768634,
-0.01889666,
-0.024958096,
-0.013061878,
-0.020593343,
-0.009610227,
-0.006806165,
-0.019207502,
-0.051314987,
-0.019026177,
0.021564728,
0.002196947,
0.018417444,
0.036239102,
-0.0025822627,
0.0018132504,
-0.021707198,
0.0038272536,
-0.029374657,
-0.0058088773,
-0.021176174,
0.0034484137,
-0.016267447,
-0.003746305,
-0.011255104,
-0.04173066,
-0.0027295894,
0.014803894,
-0.024893338,
0.0006933254,
0.01542558,
0.026330985,
0.024647253,
0.047921617,
-0.0139749795,
-0.009390047,
0.012938837,
-0.036679465,
-0.0026648305,
-0.018650575,
-0.042714998,
0.005455941,
0.0062686657,
-0.0016772567,
0.019906899,
0.013949077,
0.011909169,
-0.01078884,
-0.010309624,
0.016137928,
0.010193057,
-0.009946974,
0.00006106566,
-0.016643047,
0.000053274347,
-0.0021645676,
0.02389605,
-0.015283111,
-0.0077192658,
-0.03452947,
-0.01905208,
-0.0013461765,
-0.016422868,
-0.004973487,
0.017212927,
0.014596665,
0.026123757,
-0.000358805,
0.0055951728,
-0.007829356,
0.018922564,
-0.007479658,
-0.030825257,
-0.0068968274,
0.025955385,
-0.023662917,
-0.022406595,
0.0035293624,
0.03577284,
0.013625282,
-0.024491832,
0.04230054,
-0.016345156,
-0.002817014,
0.014829798,
-0.0030501462,
0.0016853515,
0.008710078,
0.014169256,
0.000031645875,
-0.012453144,
0.014829798,
-0.0025434075,
0.008315048,
0.005002628,
0.013534619,
0.021888522,
-0.030799353,
-0.0034095582,
0.028571645,
-0.03654995,
-0.030022245,
-0.0062913313,
0.008360379,
0.026887912,
0.020684006,
-0.022393642,
-0.010257817,
-0.030203572,
0.008852547,
-0.011378146,
0.0061488617,
-0.017031603,
0.027535502,
0.012012783,
0.001132472,
0.00023151322,
0.00660865,
0.027846346,
-0.014467148,
0.050356552,
-0.015218351,
0.012077543,
0.032042723,
0.009603751,
0.0007443231,
-0.050460167,
-0.019479489,
0.007401947,
-0.025139421,
-0.014078594,
0.037974644,
-0.0002424413,
0.06797098,
0.009927546,
-0.029866824,
0.0041154306,
-0.0022795147,
0.015464435,
-0.010374382,
0.012161729,
0.00046424067,
-0.030954774,
0.024634302,
-0.01717407,
0.006042009,
-0.03973609,
0.0078099286,
0.011786127,
-0.0010320956,
0.028701164,
0.0042805662,
-0.022704486,
0.015542146,
-0.0149981715,
0.0154385315,
0.00955842,
-0.021111416,
0.015801182,
0.04012464,
-0.013508716,
0.0031909968,
-0.012045164,
0.0063884696,
0.00952604,
-0.052325226,
0.008962638,
0.0034386998,
0.0032622318,
-0.018961418,
-0.046160173,
0.0045363638,
0.011753748,
-0.006916255,
0.005507748,
0.007518513,
-0.026758395,
-0.003558504,
0.021616535,
-0.0072465255,
-0.012187633,
-0.019207502
] |
In schistosomiasis, chronic parasite egg-induced granuloma formation can lead to tissue destruction and fibrosis, which causes much of the morbidity and mortality associated with this disease. Here we show the importance of IL-13 in the pathogenesis of schistosomiasis, and demonstrate, perhaps for the first time, the therapeutic efficacy of an IL-13 inhibitor, sIL-13Ralpha2-Fc, in the control of hepatic fibrosis. T-helper type 2 (Th2) cytokines dominate the immune response in mice infected with Schistosoma mansoni, yet the specific contributions | [
0.00096125767,
0.0010430313,
-0.0003070684,
-0.03684821,
-0.02683511,
0.01133483,
-0.058262896,
0.003851706,
-0.027582753,
-0.012015721,
0.023150288,
-0.009599226,
0.032575954,
0.018103685,
-0.002593393,
0.00425223,
0.050145607,
0.0037248733,
-0.005343658,
0.019198451,
-0.020092955,
0.015113106,
0.017262585,
-0.013617816,
-0.0062982403,
0.013324099,
0.00857789,
-0.04584665,
-0.01718248,
0.017115727,
0.0065185283,
-0.013390853,
-0.026207622,
0.013791377,
-0.008057208,
-0.019104995,
0.024578825,
0.023924634,
-0.0056740902,
0.008477759,
0.018397404,
0.00006717122,
0.01766311,
0.011361531,
-0.0011414934,
0.009225403,
-0.0016062682,
-0.026407884,
-0.036260776,
0.00062456715,
0.019639028,
-0.002893786,
-0.012636533,
-0.009539147,
-0.030306317,
-0.006722128,
0.021107616,
-0.0007831079,
0.023897933,
-0.02033327,
-0.011274751,
0.0051267073,
-0.02969218,
-0.008584565,
-0.00783692,
0.02451207,
-0.01150839,
0.0031875037,
-0.018076984,
-0.004586,
0.04782257,
0.0466744,
-0.018384052,
-0.017596355,
0.023056833,
-0.0035546506,
-0.010306818,
0.0075632287,
-0.0070158457,
0.0034445066,
0.032308936,
-0.018944787,
-0.0050132256,
0.02301678,
0.0241783,
-0.009932996,
-0.005730831,
0.032041922,
-0.0055305692,
0.00067713595,
0.00859124,
0.005810936,
0.01619452,
0.039785385,
-0.0015829043,
-0.0091853505,
-0.02101416,
0.02117437,
-0.0015236601,
-0.022763114,
-0.014018341,
-0.005507205,
0.0007968759,
-0.014645828,
-0.040052403,
0.0116352225,
-0.006258188,
0.005190124,
0.024952646,
-0.017422795,
-0.0056841034,
0.041013658,
0.0070692487,
-0.04549953,
0.011134568,
-0.0004334838,
0.021494789,
0.02001285,
0.0065385546,
-0.005046603,
0.006077952,
-0.00067254656,
0.0071426784,
-0.00074806204,
0.015366771,
0.00025512546,
-0.018130388,
-0.007903674,
-0.021775156,
-0.007790192,
0.01266991,
-0.0029855727,
0.030306317,
0.0022763114,
-0.01149504,
-0.0004099113,
-0.046727803,
-0.028624117,
-0.023630917,
-0.023470707,
-0.005724156,
0.020213112,
-0.00658862,
-0.002037666,
-0.008123962,
0.015500279,
0.024805788,
0.0031941792,
-0.0022028822,
0.010920955,
-0.020373322,
-0.019919395,
-0.0035012474,
0.0028971238,
0.000096689,
0.026568092,
-0.025086155,
0.04750215,
-0.0073162387,
-0.010146609,
0.0024114884,
-0.015633788,
0.011134568,
-0.004552623,
0.018998189,
0.026995318,
0.0032876346,
-0.0091319475,
0.009432341,
-0.012456297,
-0.013657869,
0.031214172,
-0.011748704,
0.03548643,
-0.015206562,
0.020546881,
-0.01176873,
0.021481438,
-0.011454987,
-0.023444006,
-0.015433526,
0.0073095635,
0.039278056,
-0.006601971,
-0.01040695,
0.012563104,
0.023684321,
-0.012256035,
0.0018240531,
-0.026568092,
0.024592174,
0.01716913,
0.01317724,
-0.032575954,
-0.6233222,
-0.036394283,
0.014205252,
0.007910349,
0.0017639745,
0.009779462,
0.0069157146,
-0.012603155,
-0.01667515,
0.018130388,
-0.0051500713,
0.02934506,
0.007049223,
-0.015807347,
-0.008884958,
-0.004666105,
-0.004055306,
-0.005120032,
-0.003971863,
0.0062481747,
-0.00074013503,
-0.024979347,
0.011948966,
0.021561543,
-0.003751575,
0.02568694,
0.031774905,
-0.02603406,
0.023737723,
0.035646636,
-0.031080663,
0.036260776,
-0.018410753,
-0.009305508,
0.04533932,
-0.013497659,
-0.021908663,
0.018357351,
0.031240873,
0.020907354,
-0.021935366,
-0.0134843085,
0.039411563,
-0.0005244361,
-0.025726993,
0.028597414,
0.019265205,
0.008551188,
-0.0053803725,
-0.009439016,
0.0057675457,
-0.010240064,
-0.030573333,
0.020573584,
0.015940856,
-0.009585875,
0.02017306,
-0.028544012,
0.0049264454,
0.013470958,
0.016968867,
0.027796367,
-0.01951887,
-0.020052902,
0.015219913,
0.008237444,
-0.011555118,
-0.004138748,
0.009145298,
0.01217593,
0.0033493822,
0.048543513,
-0.009746085,
0.0012374524,
0.011481688,
0.037569154,
-0.017623058,
0.025953956,
-0.022429345,
0.0028303696,
0.0020994134,
0.012115852,
-0.005740844,
0.006825597,
0.040212613,
-0.013617816,
-0.027636157,
0.028036682,
-0.0032559265,
0.02136128,
0.011822134,
0.00512337,
-0.016581694,
-0.01766311,
-0.007349616,
0.030733543,
0.0070158457,
0.007282862,
-0.0025299767,
-0.024925945,
-0.010166635,
-0.0146057755,
0.01567384,
-0.017062323,
0.011515065,
0.021988768,
-0.039945595,
0.0076166317,
0.043309998,
-0.055165507,
0.02883773,
0.0110344365,
-0.008390978,
-0.023951337,
0.0033543888,
-0.019745834,
-0.008884958,
0.017769916,
0.01150839,
-0.021721752,
0.038797427,
0.004195489,
0.013951587,
-0.028757624,
0.011141243,
0.022469398,
-0.006334955,
-0.0140049895,
-0.017916774,
-0.007122652,
0.0070158457,
0.0028787663,
0.027983278,
-0.029104745,
0.007176055,
-0.005787572,
0.040639836,
-0.006268201,
0.002149479,
-0.032736164,
-0.008177365,
-0.024004739,
0.021294527,
-0.029879091,
0.002793655,
-0.012503025,
-0.024992699,
-0.0073629664,
0.009659304,
-0.0006070442,
0.0080638835,
-0.011074489,
-0.013844781,
0.02384453,
0.0077768415,
-0.01632803,
0.03182831,
-0.030252915,
-0.0076099564,
-0.0150463525,
0.009692681,
0.017943475,
0.00224961,
0.008050533,
-0.028891133,
-0.017769916,
0.0017089025,
-0.0014769323,
-0.029158149,
-0.020787196,
-0.0053703594,
0.0042789318,
-0.027956577,
0.021054212,
0.02703537,
0.0036914963,
-0.0006950761,
-0.025887202,
-0.0058610016,
0.00959255,
-0.013410879,
-0.017956827,
0.007863621,
-0.012836794,
0.018517561,
-0.0051500713,
0.036234073,
0.019278556,
0.016181171,
0.030600036,
-0.006882338,
0.019759186,
-0.010426975,
0.010867552,
-0.009098571,
-0.014645828,
0.023283796,
0.009298833,
0.011261401,
0.01715578,
0.0040586432,
-0.017756565,
0.005029914,
-0.01853091,
0.036768105,
-0.01951887,
0.009953022,
-0.008150664,
0.028811028,
0.012543078,
0.0045659738,
0.0032859659,
-0.011234699,
-0.008477759,
0.015086405,
0.012436271,
-0.0032792904,
-0.025433276,
0.004125397,
-0.002915481,
-0.0012082475,
0.007850271,
-0.0060178735,
0.022576204,
-0.01191559,
0.012709962,
0.0027001994,
0.01751625,
0.0046827933,
-0.01667515,
-0.021454737,
0.00004495465,
-0.0040152534,
0.019906044,
-0.0066754003,
0.017569654,
-0.0073095635,
-0.008057208,
0.040105805,
0.0052602156,
0.012102501,
-0.004041955,
0.010687316,
0.013924885,
-0.005203475,
-0.007903674,
0.031053962,
0.0006854802,
-0.0067421542,
0.02317699,
-0.014165199,
0.027142178,
-0.011708653,
-0.02319034,
0.018317299,
-0.011655249,
-0.0016596714,
0.012276061,
0.023096886,
0.017449496,
0.0150463525,
-0.014111796,
-0.0013601128,
-0.005510543,
-0.0028837728,
0.0032559265,
-0.016141118,
-0.0067388164,
-0.021094264,
-0.0042589055,
-0.032629356,
0.0124162445,
0.01224936,
-0.03137438,
0.001185718,
-0.0032575955,
0.028490609,
-0.012476323,
-0.0066386857,
-0.015874103,
-0.013284046,
-0.022723062,
0.012850146,
0.007035872,
0.015446876,
-0.01484609,
-0.018090336,
0.010053153,
-0.01351101,
0.012803418,
-0.005687441,
0.014779337,
-0.0008152333,
-0.017649759,
-0.010907604,
0.0056307004,
0.002748596,
-0.030493228,
0.017876722,
-0.023871232,
0.0034211427,
-0.007436396,
-0.016434835,
-0.0052134874,
0.029798986,
0.0046327277,
-0.024578825,
-0.014619127,
-0.02883773,
-0.0045492854,
-0.006578607,
-0.013858131,
-0.00023822834,
-0.011187971,
-0.003184166,
0.007202757,
-0.003095717,
0.031961817,
0.032923073,
-0.020747144,
-0.011314804,
-0.047849268,
0.007109301,
-0.021695051,
0.00045601328,
0.029158149,
0.0008636299,
-0.001570388,
0.029211551,
0.008671345,
0.0146057755,
-0.04683461,
0.033457108,
-0.027662858,
0.013871482,
0.001859099,
-0.0057174806,
0.007850271,
0.0028821041,
0.010440326,
0.017756565,
-0.012776717,
0.007202757,
0.009192026,
0.014739284,
0.008397654,
0.015300018,
0.031935114,
0.013951587,
-0.0028370451,
-0.011314804,
0.020600285,
0.010867552,
-0.03447177,
-0.0051667597,
0.00092454295,
0.007489799,
0.010720693,
-0.0066987644,
0.0065986332,
-0.012309439,
-0.01101441,
-0.00741637,
0.013243995,
0.010827499,
0.021962067,
0.018290596,
0.00857789,
-0.0024431965,
-0.012629857,
-0.031748205,
0.009892943,
-0.0026000685,
-0.00053444924,
0.03286967,
-0.0017656434,
-0.0049231076,
-0.015540332,
0.016301328,
-0.01175538,
-0.00396185,
-0.011288102,
0.007910349,
-0.0029955858,
-0.01333745,
-0.017048972,
0.019265205,
-0.01217593,
-0.011935616,
-0.03265606,
-0.00037945478,
-0.015780646,
-0.02568694,
-0.011114541,
-0.0035479753,
-0.036501087,
-0.015460227,
0.0060913027,
-0.0075298515,
0.0060712765,
0.012002369,
-0.0032459134,
0.008284172,
0.0032742838,
-0.0038450307,
-0.028196892,
0.0055939853,
-0.023070183,
0.03134768,
-0.004282269,
0.0052702287,
-0.014138497,
-0.015286666,
0.007937051,
0.033750825,
0.008798177,
-0.025259715,
0.0020626986,
0.002025984,
-0.0028637468,
0.028223593,
-0.01116127,
-0.0064551122,
-0.019545572,
-0.00809726,
-0.020279866,
-0.00683561,
-0.005867677,
-0.00054446235,
-0.0013025375,
0.010273441,
0.0047228457,
-0.028437205,
-0.005046603,
0.02883773,
-0.0046460787,
0.004505895,
-0.00529693,
0.006935741,
0.03281627,
-0.0035680016,
0.00006925728,
0.018731173,
-0.0017472861,
-0.01133483,
0.008524486,
0.028784325,
0.024952646,
-0.02085395,
-0.016141118,
0.0066987644,
-0.008477759,
-0.02618092,
-0.028063383,
0.0025449963,
0.02517961,
0.0010438657,
-0.026314428,
-0.044725183,
0.012195956,
-0.029558674,
0.011855511,
-0.0113214785,
-0.011114541,
0.012529726,
0.022068873,
-0.0067488295,
-0.015780646,
0.010413624,
-0.03551313,
-0.024832489,
0.015567034,
0.02101416,
-0.0006045409,
0.010620562,
-0.00049523124,
-0.009979723,
0.01268326,
-0.017209182,
-0.019051593,
0.0038350176,
-0.028730923,
0.040212613,
0.038904235,
0.029078044,
-0.0063883583,
0.031587996,
0.0042789318,
-0.0025566784,
0.004986524,
0.0057642083,
0.020106306,
-0.013464282,
0.018424105,
0.005724156,
-0.009652629,
0.023617566,
-0.028196892,
0.025927255,
0.022055523,
-0.017823318,
-0.01885133,
-0.0020944069,
-0.023617566,
-0.013924885,
0.020600285,
0.00032855486,
0.0011573476,
-0.029905794,
-0.010453677,
0.015700541,
0.0029955858,
0.0057174806,
-0.0075432025,
0.0057675457,
-0.005423763,
0.003995227,
-0.012836794,
0.007917025,
0.00083817996,
0.00058785244,
0.011722003,
0.012810093,
0.008597916,
0.007182731,
-0.017916774,
0.007569904,
-0.007863621,
0.024084844,
-0.010927631,
-0.02282987,
-0.0068956884,
-0.01100106,
-0.0056841034,
-0.007436396,
-0.026287727,
-0.013951587,
-0.043657117,
-0.0026434585,
0.00320753,
-0.020506829,
0.009706032,
0.00021736772,
-0.014098446,
0.01648824,
0.0012266048,
0.010467027,
-0.027422544,
0.022789817,
0.03017281,
-0.0025633536,
-0.013924885,
-0.0110344365,
0.0134576075,
-0.010814149,
0.038156588,
0.012503025,
-0.007950402,
-0.024138248,
0.019745834,
0.0066386857,
-0.002406482,
-0.020319918,
0.00055864756,
0.025980659,
-0.0094189895,
-0.02300343,
-0.013284046,
-0.025419924,
0.022082224,
0.0002465726,
0.011254725,
-0.012302763,
0.020960758,
-0.006418397,
-0.011141243,
-0.01451232,
0.022335889,
-0.017249234,
-0.018103685,
-0.017396092,
-0.026634848,
0.00095124455,
0.02282987,
0.0083242245,
0.031294275,
-0.0064384234,
0.0038383552,
0.00045392723,
0.032041922,
0.005820949,
-0.00087113975,
-0.007136003,
0.038236693,
0.0035112605,
0.010313493,
0.00529693,
0.010059828,
0.013370827,
-0.039625175,
0.00052151567,
0.0055339066,
-0.022135627,
0.0033043232,
0.038049784,
0.011434961,
0.0009721052,
0.012342815,
-0.014125147,
-0.016207872,
-0.009485744,
-0.020133007,
0.004806288,
-0.021721752,
0.0044491543,
0.0020727117,
0.0156204365,
0.0073896684,
0.01058051,
-0.012763365,
0.009819514,
0.030039301,
-0.02985239,
-0.0057642083,
-0.00006028721,
0.008784827,
-0.006131355,
-0.011648574,
-0.012122527,
-0.028917834,
-0.01619452,
-0.016501589,
-0.045472827,
-0.023897933,
0.019064942,
0.0064284103,
-0.0023163639,
-0.011835485,
0.027502649,
0.016888762,
0.022549503,
-0.024752384,
-0.019946096,
0.04571314,
0.008397654,
-0.014058393,
0.000025228319,
0.0045359344,
0.004185476,
-0.0023664294,
-0.0091853505,
0.003184166,
0.016261276,
-0.015927505,
0.008918335,
0.0037882896,
-0.022883272,
-0.015860751,
-0.0071493536,
-0.021895314,
-0.007856946,
-0.0069290656,
0.0048363274,
-0.016274625,
-0.027876472,
-0.002106089,
-0.0006266532,
0.012556428,
-0.0034111296,
-0.009265455,
0.0064484365,
-0.028570713,
-0.043790627,
0.006882338,
-0.026501339,
0.051747702,
-0.0034211427,
0.022335889,
-0.009772786,
-0.0080638835,
-0.040906854,
-0.013310748,
0.019612325,
-0.008390978,
0.015406824,
0.010954332,
-0.0085578635,
0.022536151,
-0.022576204,
-0.010360221,
0.0026668224,
-0.01699557,
0.00034899826,
0.002791986,
0.023590865,
0.008991764,
-0.025313118,
-0.021281175,
0.040292718,
0.005957795,
-0.0029538646,
0.020453427,
-0.013490984,
0.013470958,
-0.023150288,
0.010734044,
-0.0062248106,
-0.011228023,
0.01667515,
-0.024044791,
0.0052335137,
-0.0043690493,
0.0022379279,
-0.002403144,
0.00525354,
-0.0029254942,
0.0066987644,
-0.0019241842,
0.0049464717,
-0.008030507,
-0.0016321354,
-0.029478569,
0.030733543,
0.009672655,
-0.0066286726,
0.022536151,
0.024832489,
-0.012376192,
-0.021147668,
0.023924634,
0.010874227,
0.0056039984,
0.0006838113,
-0.009405639,
-0.0072294585,
-0.00252497,
-0.015086405,
-0.0102267135,
0.0040586432,
-0.017916774,
-0.0089517115,
-0.037088525,
0.014218602,
0.02150814,
-0.0042689187,
-0.027689561,
-0.00420884,
-0.006521866,
-0.013844781,
-0.006244837,
-0.016568344,
-0.0037315488,
0.0012666573,
0.015300018,
-0.018036932,
0.0028153502,
0.0010622231,
-0.016848711,
-0.028143488,
0.012155904,
0.18498869,
-0.009479068,
0.0073829927,
-0.0038416928,
0.00087447744,
-0.00059411064,
0.030653438,
-0.008537837,
-0.0075165005,
0.0004735362,
0.024285106,
-0.0054003987,
-0.0070024948,
-0.0018490859,
-0.0010179986,
-0.024151599,
-0.030626737,
0.012329465,
-0.021227773,
-0.021654999,
0.019425415,
0.011742029,
0.0046127015,
-0.0014260324,
0.03986549,
0.018210491,
-0.044671778,
0.014579074,
0.022415994,
0.01867777,
-0.003295979,
0.015607086,
-0.007903674,
0.015994258,
-0.012596481,
-0.004075332,
-0.020213112,
-0.02465893,
0.0067521674,
0.0077434643,
-0.026661549,
0.01869112,
-0.02700867,
0.006178083,
-0.0076099564,
0.00013924467,
-0.011328154,
-0.005977821,
-0.006868987,
-0.0052268384,
-0.025994008,
-0.014966248,
0.0099396715,
0.03735554,
-0.004409102,
-0.024725683,
0.017249234,
0.0037983027,
0.004142086,
0.02299008,
0.0011490033,
0.031961817,
-0.012349491,
0.029398464,
-0.022375941,
0.041387483,
-0.030386422,
-0.0081172865,
-0.014418865,
-0.014859441,
0.0076967366,
-0.023457356,
-0.017943475,
-0.0108542,
-0.017262585,
-0.019959446,
0.029798986,
-0.0013359145,
0.007917025,
0.026127517,
-0.0037549126,
-0.001580401,
-0.015700541,
0.017569654,
-0.0038216666,
-0.02982569,
0.036661297,
0.010413624,
-0.041227274,
0.010326845,
-0.0045492854,
0.012436271,
-0.011528417,
-0.018397404,
0.024044791,
0.0013267358,
-0.011021086,
-0.0051734354,
0.0004923108,
-0.0015411831,
-0.020747144,
0.073162384,
0.0031591333,
0.0020493479,
-0.011888888,
0.012716638,
-0.005710805,
0.0053603463,
-0.016661799,
0.008798177,
0.009699357,
-0.013203942,
0.003404454,
-0.008637968,
0.0030456514,
0.019318609,
0.004212178,
-0.00053194596,
0.025353171,
-0.0033527198,
-0.019064942,
-0.025419924,
0.0027903174,
0.020400023,
-0.030653438,
-0.013524361,
-0.018891383,
0.002948858,
-0.012309439,
-0.03556653,
0.0003502499,
0.001007151,
-0.0063082534,
-0.013390853,
0.01718248,
0.0083509255,
-0.0033860968,
-0.020466777,
-0.011968993,
0.023737723,
-0.0049164323,
0.004996537,
0.008891633,
-0.016715202,
0.012556428,
-0.0031124053,
0.015874103,
0.017636407,
-0.023617566,
-0.031614695,
-0.017369391,
-0.033911034,
0.0043824003,
-0.016822008,
0.044751883,
-0.03599376,
-0.020426724,
-0.02152149,
-0.0027586091,
-0.006875662,
-0.026154218,
0.01433876,
0.028437205,
-0.013070433,
-0.025873851,
0.000065867425,
-0.16768606,
0.004212178,
0.022656308,
-0.028757624,
0.025793746,
-0.0036447686,
0.009198702,
-0.002937176,
-0.0026868486,
0.005453802,
0.03252255,
0.0126498835,
-0.042402145,
-0.026915215,
-0.005650726,
0.021054212,
-0.0099663725,
0.029078044,
0.036287475,
0.01783667,
0.037248734,
-0.017583005,
0.004265581,
-0.016728554,
0.016888762,
0.009619252,
-0.00029622088,
-0.017743215,
-0.008224093,
-0.005063291,
-0.022202382,
0.011822134,
0.038049784,
-0.009652629,
0.0024732358,
0.0012432933,
-0.014405514,
-0.007483124,
-0.01700892,
0.037275434,
0.033644017,
0.012529726,
0.0050833174,
-0.000820657,
-0.03471208,
0.028036682,
-0.0037782765,
0.014926195,
0.035593234,
-0.007603281,
0.009258781,
0.0036247424,
0.0077100876,
0.0083242245,
0.0131972665,
0.01815709,
-0.0006775531,
0.019305257,
0.0026067437,
0.011615196,
-0.028490609,
-0.027248984,
0.016728554,
-0.013737974,
0.01433876,
-0.016728554,
-0.015860751,
0.012482999,
-0.012182605,
0.02300343,
-0.027369142,
-0.0027886485,
-0.0047662356,
-0.008344251,
0.012382868,
0.0145523725,
-0.0039117844,
0.029612076,
0.021735104,
0.016595045,
-0.017235884,
0.015139808,
-0.01351101,
-0.018210491,
-0.024925945,
0.01283012,
-0.0054471265,
0.01634138,
-0.028036682,
-0.008544512,
0.017649759,
-0.01192894,
-0.0030823662,
-0.020667039,
0.0056206873,
0.020693742,
0.0056240247,
0.011795432,
-0.0069424165,
0.0061747455,
0.027235633,
-0.028116787,
-0.0052401894,
0.018637717,
0.016635098,
-0.02248275,
-0.014939546,
0.005807598,
0.06435086,
-0.007369642,
-0.0008961725,
-0.0006187262,
0.0048463405,
0.0073829927,
-0.0038650567,
0.0027335763,
0.011661924,
-0.008150664,
-0.0019575611,
-0.027248984,
0.07273516,
0.007930376,
0.00097460847,
0.012963627,
-0.015740594,
-0.01735604,
-0.13543051,
-0.009605901,
0.0019959447,
0.022402644,
-0.00095374783,
0.012009045,
-0.0023347212,
0.00883823,
-0.0003502499,
0.007496475,
-0.025446625,
-0.0012065786,
-0.013123837,
-0.010179985,
0.015073054,
0.0038049782,
0.0032742838,
0.0021294528,
0.00396185,
0.04120057,
-0.010073179,
-0.0099663725,
-0.018223843,
-0.0129369255,
-0.00271355,
0.023484059,
-0.017609706,
0.031160768,
0.008177365,
0.020987459,
0.025273066,
-0.00758993,
0.023871232,
0.002281318,
-0.014966248,
-0.009258781,
-0.0073829927,
-0.0016313009,
0.03035972,
-0.02918485,
-0.00023593368,
-0.010273441,
0.009726059,
0.018370701,
0.01258313,
-0.004028604,
-0.035459727,
0.008017155,
0.049611576,
-0.023070183,
-0.028597414,
-0.049077544,
-0.021614946,
-0.004899744,
0.018944787,
-0.020733794,
-0.0008385972,
0.034097943,
-0.03150789,
0.019291908,
0.003095717,
-0.023457356,
-0.011481688,
0.0021511477,
0.026127517,
0.00059411064,
-0.015326719,
-0.025593486,
0.019986149,
-0.04552623,
-0.021241125,
-0.005664077,
-0.024819138,
-0.009232079,
-0.0063182665,
0.009866241,
0.005824287,
-0.020667039,
-0.0097327335,
-0.020106306,
-0.020039551,
-0.011802108,
0.012523051,
-0.009572524,
0.03535292,
-0.0009086889,
0.0037749389,
-0.005066629,
0.003095717,
0.0016955517,
-0.012876847,
0.039598476,
-0.003517936,
-0.01783667,
-0.0036514439,
0.016020961,
-0.025580134,
-0.006868987,
0.022429345,
0.025273066,
-0.02734244,
-0.045579635,
-0.055913154,
0.017115727,
0.010974358,
-0.010967683,
0.0017422795,
-0.016595045,
0.010300143,
0.0030706841,
0.0017673122,
0.00069465884,
-0.015193211,
0.019625677,
-0.027142178,
0.00734294,
-0.030706841,
-0.009986399,
0.034498468,
0.013991639,
0.029451866,
0.010727368,
-0.013591115,
0.00039176256,
-0.011101191,
0.022095576,
-0.022950027,
0.0060812896,
0.00024031442,
0.012229334,
-0.025713641,
-0.0010205018,
-0.0097327335,
-0.04555293,
-0.01301703,
0.005106681,
-0.017035622,
-0.020934055,
0.009065194,
0.03967858,
0.008077234,
0.045125708,
0.005650726,
-0.01985264,
0.025273066,
0.00052485336,
0.018584315,
-0.00016104404,
-0.0086112665,
0.013657869,
0.0072294585,
-0.018624367,
0.021628298,
0.00875145,
-0.0156204365,
-0.0076166317,
-0.009726059,
-0.0060746144,
-0.0042589055,
-0.008784827,
-0.006735479,
-0.011301452,
-0.018544262,
0.009459042,
0.0055305692,
0.0088449055,
0.0015403486,
-0.01818379,
-0.018477509,
0.006057926,
0.023457356,
-0.017449496,
-0.033483807,
0.0055172183,
-0.00058534916,
-0.00043807316,
-0.0022562854,
0.018277247,
0.0014176881,
-0.0044224528,
-0.001925853,
0.007136003,
0.006601971,
0.001663009,
-0.035539832,
0.017089024,
0.018450806,
0.0010597198,
0.0018874694,
0.028063383,
-0.0038116535,
0.0031908413,
0.006855636,
0.01499295,
0.018837979,
0.0045926753,
0.0208139,
0.013938236,
0.024311809,
0.009071869,
-0.0066954265,
0.038557112,
0.014258655,
-0.0013025375,
0.0036981718,
-0.008904984,
-0.007783517,
0.010353546,
-0.023323849,
-0.03586025,
0.013604466,
0.0051634223,
-0.0041687875,
0.012189281,
0.016541641,
-0.0017389418,
-0.025633538,
0.030546632,
-0.018103685,
-0.008851581,
-0.007496475,
0.029398464,
0.006665387,
0.012890198,
-0.015126457,
-0.022095576,
-0.006144706,
-0.008451057,
0.034631975,
-0.044351358,
0.021922015,
-0.0023981375,
0.009378937,
0.008965063,
-0.04288277,
0.0029238253,
-0.004409102,
-0.012022396,
0.022389293,
0.01799688,
-0.019478818,
0.09318859,
0.016648449,
-0.013270696,
0.011328154,
-0.008057208,
-0.0018507547,
0.0088716075,
0.033377003,
-0.009172,
-0.05804928,
0.030146107,
-0.013751324,
0.031748205,
-0.037195332,
-0.041547693,
0.007576579,
-0.013804728,
0.024458667,
-0.014792687,
0.0033927723,
0.02166835,
0.020760495,
0.0034311558,
0.009138623,
-0.018891383,
0.0047695735,
0.02684846,
-0.01619452,
0.01009988,
-0.04285607,
-0.021855261,
0.024565473,
-0.023951337,
-0.024031442,
-0.00683561,
-0.010286792,
-0.0003961433,
-0.0055472576,
0.021241125,
0.025620187,
-0.0017089025,
0.012903549,
-0.03084035,
-0.027449246,
-0.0063916957,
-0.014325409,
-0.02517961,
-0.00062164664,
-0.026634848
] |
The validity and reliability of observational methods for studying medication administration errors (MAEs) were studied. Between January and June 1998, two pharmacists observed consecutive drug administration rounds by nurses on two wards in a U.K. hospital and recorded all MAEs identified. The observers intervened in cases of potentially harmful errors. MAE records were audited to determine the percentage of omitted doses for which a corresponding reason was documented for the observation periods and for nonobservation periods. Error rates for each drug administration round were analyzed according to whether they were for the nurse's first, second, third (and so on) observed round. Error rates were calculated | [
-0.015953828,
0.015138082,
-0.0032813665,
-0.045253772,
-0.0014919102,
0.015753234,
0.014656659,
0.0014852238,
-0.016876554,
0.005536366,
-0.0093142,
0.003731029,
-0.0077629476,
0.022025106,
-0.017063774,
-0.012991738,
0.028189998,
0.012296349,
-0.012430077,
-0.01178818,
-0.031345993,
0.027655084,
-0.033405416,
0.016729454,
0.002856778,
0.0011433798,
-0.00061640545,
-0.032656536,
-0.021597175,
-0.010745096,
0.0041556177,
-0.034288023,
-0.0025023972,
-0.028296981,
-0.021396583,
-0.0068335338,
-0.0038647577,
-0.025328204,
0.006562733,
-0.006994008,
0.01960462,
-0.0007555668,
0.019885449,
-0.008485083,
0.008953133,
0.011239892,
0.012751026,
-0.014496185,
-0.036160223,
0.032923993,
0.011353562,
-0.0050716586,
-0.0077629476,
0.004921214,
0.023442632,
0.0023870561,
0.007415253,
0.013486533,
0.0016966822,
-0.021115752,
-0.023589732,
0.017772537,
-0.031132028,
0.013412982,
-0.020607583,
0.007241406,
0.0064022588,
0.0022884314,
0.003007223,
-0.021677412,
0.030811079,
0.0022282535,
0.003125907,
-0.019511009,
0.03423453,
-0.00588406,
-0.006589479,
0.009347632,
0.0062585003,
0.004550117,
0.0076559647,
0.006749953,
-0.030329656,
0.035224125,
-0.00023109981,
-0.0016858167,
0.002768183,
0.0275481,
0.016127674,
-0.0025224565,
0.007548982,
0.02357636,
0.035491582,
0.008251057,
-0.0029503882,
0.007963541,
0.0001526387,
0.03487643,
-0.0004789157,
-0.006566076,
-0.014215355,
0.018360943,
-0.030436639,
-0.0038714441,
-0.011661137,
-0.014001389,
-0.033539142,
-0.010430834,
-0.003620703,
0.012369899,
-0.0088795815,
0.040439542,
-0.0036474487,
0.004068694,
-0.008672303,
0.0072614653,
0.013894406,
-0.0076359054,
-0.017050402,
-0.032041382,
0.0051184637,
0.025756136,
0.016970165,
-0.0061180852,
0.020768058,
-0.0012094084,
-0.0055530816,
-0.018762128,
0.00025659183,
0.0010414118,
0.018307451,
-0.0069672624,
0.027601592,
0.020928532,
-0.015793353,
0.020580838,
-0.035170633,
-0.0026411407,
-0.0159672,
-0.028724913,
-0.0030924748,
0.008344667,
-0.0133862365,
0.011935282,
-0.02786905,
0.040439542,
0.021958243,
0.016221285,
-0.0019624678,
0.0000129223135,
0.015499149,
-0.008712421,
-0.013459788,
-0.01624803,
-0.0046169814,
0.0098357415,
0.012035578,
0.024405478,
-0.05873362,
-0.029874979,
-0.010370656,
-0.0011199773,
0.016729454,
-0.037283543,
-0.007756261,
0.02012616,
-0.028083015,
-0.018240586,
0.013613576,
-0.010196809,
-0.014108372,
0.013212389,
-0.027160287,
0.017745791,
0.029420301,
0.013499906,
-0.016609097,
0.019898823,
-0.018788874,
-0.021891378,
-0.012777772,
0.013399609,
0.024646189,
0.0056466917,
-0.015258438,
-0.003271337,
-0.010323851,
0.018935975,
-0.010785215,
-0.006729894,
0.006188293,
0.013687126,
-0.025100866,
-0.006459093,
-0.64318126,
-0.01709052,
-0.0021764336,
-0.0012277961,
0.003510377,
0.020808177,
0.02366997,
0.003590614,
0.013185644,
0.044558384,
-0.00580048,
0.025475306,
0.03487643,
-0.013947898,
-0.016141048,
-0.008210938,
-0.009434556,
-0.02712017,
0.01858828,
-0.007769634,
-0.018334197,
0.023750206,
-0.0038647577,
0.021557057,
0.006094683,
0.0011099477,
0.02185126,
-0.018427806,
-0.007228033,
0.006900398,
-0.0053758915,
0.010109886,
0.01073841,
0.028564438,
0.03795219,
-0.014843879,
-0.0142421005,
0.015044472,
-0.00027686008,
0.025502052,
-0.011895163,
-0.00013592263,
0.0248869,
0.0068736523,
-0.0042057657,
-0.004269287,
0.003497004,
0.0048677227,
0.001501104,
-0.009695327,
0.0018120231,
-0.016595725,
-0.014576422,
0.0031777269,
0.011179714,
0.019898823,
0.009655208,
-0.0051184637,
0.00826443,
0.00580048,
-0.0123297805,
0.0064758095,
-0.027334135,
-0.013018483,
-0.0050215106,
0.013894406,
-0.0052689086,
0.0017468304,
-0.0026277679,
-0.021276226,
0.010557876,
0.031666942,
-0.014068253,
-0.0059141493,
0.027227152,
0.012149247,
0.0033833347,
-0.019136569,
-0.009307513,
-0.0064657796,
-0.028778404,
0.003032297,
-0.051191323,
0.014870625,
0.03305772,
0.0060278187,
-0.010404089,
-0.005288968,
-0.00636214,
-0.012837949,
0.009561597,
0.0064457203,
0.014094999,
-0.03236233,
-0.01006308,
0.014990981,
-0.0052989973,
-0.0024823379,
0.030169182,
-0.023268783,
-0.028189998,
0.005064972,
0.017518451,
0.0015654609,
0.0011316786,
0.014937489,
-0.0169033,
0.015218319,
0.051859967,
-0.021516938,
0.019992432,
0.003744402,
0.005385921,
0.014108372,
0.014817134,
-0.030329656,
0.008538574,
0.015699742,
-0.017959757,
-0.014509558,
0.023643224,
-0.003854728,
0.027815558,
0.0032863813,
0.008672303,
-0.000004600187,
-0.010450893,
-0.0024806664,
0.0053290864,
0.005275595,
0.006880339,
0.00068326975,
0.0066964617,
-0.0015846844,
0.012075696,
-0.00654936,
0.014456066,
-0.021744277,
-0.0067131775,
0.0041957363,
-0.00948136,
0.029072607,
0.0075556682,
-0.013372864,
0.012510315,
-0.03870107,
-0.0054695015,
0.009568284,
-0.008331294,
0.026130576,
0.016408505,
-0.007869931,
-0.01737135,
0.02016628,
-0.01169457,
-0.0018922603,
-0.037283543,
-0.01377405,
-0.031132028,
0.002550874,
0.013907779,
0.03926273,
-0.037898697,
-0.02138321,
0.0048075444,
-0.03273677,
0.01377405,
-0.003543809,
-0.025889864,
-0.0525821,
0.015405539,
-0.01900284,
0.001880559,
0.01896272,
0.011728002,
0.035117142,
-0.010163377,
0.00006362558,
0.0151113365,
-0.026424779,
0.01600732,
0.022091972,
-0.017973129,
-0.0050382265,
0.0128112035,
0.006639627,
0.0043729264,
-0.012878068,
-0.00512515,
0.031533215,
-0.016368385,
0.013352805,
0.009788937,
0.0009101906,
0.0035638683,
0.003450199,
0.011647765,
0.015713116,
-0.016956791,
0.033084467,
0.029634267,
0.012757712,
0.018187094,
0.008351354,
0.014750269,
-0.001842112,
-0.0028133162,
-0.021730904,
0.022987952,
-0.0014008075,
0.0015529238,
-0.005743645,
-0.011340189,
-0.02736088,
-0.022894343,
0.00023506988,
-0.011901849,
0.030837825,
-0.006021132,
-0.004600265,
-0.010417461,
-0.018574908,
0.04501306,
0.015392167,
0.014081626,
0.0037878638,
0.032255348,
0.007923422,
0.00008196103,
0.0077495747,
-0.0037410588,
0.0035504955,
-0.00018701114,
0.011400366,
0.019805212,
0.014135118,
-0.0009787265,
-0.0073149567,
0.017705671,
-0.0032345615,
-0.0214367,
0.0045467736,
0.012309722,
0.0006368827,
0.012784458,
-0.018294077,
0.007007381,
0.024311867,
0.017625434,
0.0016055795,
0.009882547,
0.01234984,
-0.007288211,
0.000661121,
-0.0212896,
-0.011099477,
0.02338914,
0.026077084,
0.015525895,
0.023696715,
0.02843071,
0.0073550753,
0.00004808485,
-0.021316346,
-0.011801553,
-0.0108855115,
-0.006111399,
0.0043562106,
-0.011353562,
-0.031185519,
-0.019631365,
0.0019089764,
-0.0035036905,
0.009541539,
0.029045861,
-0.009655208,
0.0046571,
-0.007207974,
0.028457455,
0.0057035265,
-0.03950344,
-0.02441885,
0.02119599,
0.012797831,
0.0073617618,
0.004583549,
0.013085348,
-0.0010865452,
-0.036400937,
0.013326059,
-0.004877752,
0.012396645,
-0.017826028,
-0.015499149,
0.010932316,
-0.006392229,
0.04207103,
0.011587587,
0.005429383,
0.0030439983,
-0.0019641395,
-0.018160349,
-0.0053157136,
-0.034421753,
0.006285246,
-0.00078565575,
-0.027976032,
-0.04062676,
-0.011701256,
0.0010740082,
0.0070474995,
0.0073751346,
-0.0027698544,
0.0037477452,
-0.0074954904,
0.014656659,
-0.048490006,
-0.0044665365,
0.016515488,
0.0033549173,
0.008070524,
-0.021423329,
0.023014698,
0.011821612,
0.05953599,
-0.0012077368,
0.016782945,
0.015285184,
0.0015504165,
-0.0022182239,
0.005359175,
0.007903363,
-0.00023715939,
0.02614395,
-0.015097964,
0.0023603104,
0.037042834,
0.0027748693,
0.023696715,
0.016542234,
0.011146282,
-0.040466286,
0.0072948975,
-0.006579449,
0.018146977,
-0.014990981,
0.0275481,
0.009267394,
0.0117547475,
-0.015097964,
0.021343092,
0.005680124,
0.0027347507,
-0.008632184,
0.013439728,
0.024084529,
-0.022346055,
0.008886268,
-0.007114364,
0.016983537,
0.0151113365,
0.0028233458,
0.014094999,
-0.015566014,
0.009187157,
0.021583803,
-0.005078345,
-0.0063387374,
0.018842366,
-0.014870625,
0.02712017,
0.025876492,
-0.024298495,
-0.021450074,
-0.00474068,
-0.009668581,
-0.013693813,
-0.017491706,
0.023990918,
-0.0025140985,
0.015017726,
0.0021463446,
-0.031399485,
0.006318678,
-0.017357977,
-0.0034936608,
0.00094529433,
-0.0033699616,
-0.024245003,
-0.0056567215,
-0.017438214,
-0.00409544,
-0.0062585003,
-0.0003334858,
-0.013372864,
-0.0043896427,
-0.013988016,
0.0067833853,
0.00819088,
0.022653632,
0.028965624,
-0.0039349655,
-0.0019089764,
0.024124647,
-0.017678926,
0.023549614,
-0.035518326,
-0.011199773,
0.008331294,
0.031025045,
0.00299385,
-0.030570367,
-0.020246517,
0.017772537,
0.031907655,
-0.016221285,
0.054079864,
-0.019992432,
-0.00409544,
-0.016702708,
-0.013132152,
0.032148365,
0.0012478554,
-0.02310831,
-0.004874409,
-0.0023552957,
-0.02372346,
-0.029981961,
0.015900336,
0.0025174418,
-0.027387626,
0.011340189,
0.0063387374,
-0.0065593896,
0.00085920654,
-0.02278736,
0.0052555357,
-0.009962784,
0.023616478,
0.028564438,
0.01750508,
0.049479596,
0.0039918,
0.0050850315,
0.00485435,
0.023322275,
0.026050339,
-0.00588406,
-0.027655084,
0.022453038,
-0.022252446,
0.0026829308,
-0.034421753,
0.006519271,
0.0055497386,
0.032148365,
-0.004102126,
-0.034395006,
-0.020768058,
-0.018120231,
-0.015632879,
0.016502114,
0.004670473,
-0.0013163913,
-0.0079167355,
-0.007408567,
0.0051786415,
0.0050382265,
0.04038605,
-0.022814106,
-0.00004299167,
0.00828449,
-0.028296981,
0.0073751346,
0.013566771,
-0.0029671043,
-0.0133862365,
-0.0053959507,
-0.021557057,
-0.004319435,
-0.021690786,
0.007956854,
0.015057845,
0.019083077,
0.022305937,
-0.0069538895,
-0.000023180502,
-0.0021730904,
-0.0053926073,
-0.00017802625,
-0.028029524,
0.0018939319,
-0.0007522236,
0.011520722,
0.015057845,
0.00028709866,
0.018909229,
-0.0004601101,
0.012958305,
-0.0035973005,
0.0033248283,
-0.02256002,
-0.017050402,
-0.029259827,
-0.0071678553,
-0.008705734,
0.0077963797,
0.008344667,
-0.024967138,
0.009508106,
0.005245506,
0.0015596102,
0.0032679937,
-0.027414372,
0.0012186023,
-0.016956791,
0.014442693,
-0.011962027,
0.011968713,
-0.02647827,
-0.024485715,
-0.028537693,
-0.015365421,
0.0013188988,
0.019230178,
0.015459031,
0.030463384,
-0.012690848,
-0.010865452,
0.00903337,
-0.0058105094,
-0.0038747874,
-0.010778529,
-0.048249293,
-0.0046871887,
-0.0038179527,
0.020340126,
0.0031526526,
-0.015900336,
0.0107919015,
0.0037076266,
0.02423163,
-0.02647827,
-0.02054072,
0.004690532,
-0.03763124,
0.028751658,
0.01099918,
-0.0093543185,
0.017612062,
-0.008799344,
-0.005195358,
0.012062323,
0.02250653,
-0.011534095,
0.009153726,
0.012510315,
-0.026277678,
0.0015102979,
-0.00041664828,
-0.009521479,
-0.02110238,
-0.034475245,
0.051672745,
0.0066028517,
-0.022854224,
-0.006201666,
0.013453101,
-0.027374253,
0.04394323,
0.0023636536,
-0.022680378,
0.006716521,
-0.018762128,
-0.023643224,
0.02955403,
-0.020781431,
0.009394437,
0.0053524887,
-0.011821612,
-0.003931622,
-0.013707186,
-0.018200468,
0.01638176,
-0.03792544,
0.0067566396,
0.003433483,
0.01564625,
0.006994008,
0.002051063,
0.0014033149,
-0.032656536,
-0.032148365,
0.028216744,
0.002831704,
0.0038915034,
0.029126098,
-0.00987586,
0.00016444444,
-0.016421877,
-0.015993945,
-0.02861793,
-0.0044765663,
0.013506593,
-0.0014484484,
0.03273677,
-0.020005805,
-0.004901155,
-0.025515424,
-0.010618054,
0.012450136,
-0.028778404,
0.018722009,
-0.015713116,
-0.029126098,
0.008618811,
-0.005242163,
0.020340126,
0.009147039,
-0.0050482564,
0.0021563743,
0.0063119917,
-0.008144074,
0.011025926,
-0.004399672,
0.00057545106,
-0.022252446,
-0.021115752,
-0.019631365,
-0.021075634,
0.008117328,
-0.008739167,
-0.054775253,
-0.012670789,
0.0027665112,
0.0068034446,
0.0070943045,
-0.008672303,
0.029794741,
-0.0032328898,
0.0044063586,
-0.0012403332,
0.001539551,
0.022573395,
-0.04332808,
0.019029586,
0.021971615,
-0.0012252887,
-0.024245003,
-0.010069767,
0.003125907,
-0.01309872,
-0.039476696,
0.029687759,
-0.019898823,
0.030784333,
-0.032897245,
-0.0060445345,
-0.0023385796,
0.0058539715,
-0.008291176,
0.034020565,
0.010016276,
-0.010236927,
-0.011814926,
-0.026304424,
-0.006843563,
0.032415822,
-0.0031526526,
0.011734689,
0.0033114555,
0.0006297783,
-0.019952314,
-0.007321643,
-0.032629788,
0.038968526,
0.007134423,
-0.003928279,
-0.016408505,
-0.037230052,
-0.0065827924,
0.003463572,
0.018895857,
0.007087618,
0.003868101,
0.01881562,
0.014883998,
0.02357636,
-0.005275595,
-0.014763642,
-0.03450199,
-0.01099918,
0.011935282,
-0.028109761,
0.011353562,
-0.015138082,
-0.04137564,
0.0073149567,
0.011915222,
0.0020276606,
-0.013499906,
0.012837949,
0.007488804,
-0.03305772,
0.008772599,
-0.016314894,
0.0068937116,
-0.0043127486,
0.016234657,
-0.035571817,
-0.00835804,
-0.004051978,
0.01099918,
-0.04001161,
0.0024104586,
0.02629105,
-0.014977608,
0.02726727,
-0.0026678864,
0.007883304,
0.016395131,
-0.00446988,
0.0059475815,
0.012490255,
-0.0136737535,
0.027628338,
-0.008184193,
-0.01008314,
-0.014777015,
-0.010711664,
-0.01377405,
-0.004162304,
-0.0012821234,
-0.008785971,
0.010805274,
0.019123195,
0.0052221036,
0.0012328109,
0.0080103455,
0.008210938,
-0.013125466,
-0.013372864,
-0.0018922603,
-0.0108855115,
0.009080174,
0.003010566,
-0.014469439,
-0.003125907,
-0.012550433,
-0.031105282,
0.013392923,
-0.033004228,
0.004055321,
-0.0049178707,
-0.013921152,
0.023803698,
0.018949348,
-0.0037811773,
-0.011534095,
0.041429132,
0.18839692,
-0.007147796,
-0.028270235,
0.033646125,
-0.012008832,
-0.02203848,
0.029259827,
0.0052521923,
-0.011855044,
0.037818458,
0.036614902,
0.002260014,
-0.027628338,
0.0058305687,
0.0072213467,
-0.015258438,
-0.01662247,
-0.02670561,
0.017357977,
0.02507412,
0.0031827416,
0.006408945,
0.0062451274,
0.0031994577,
0.031426232,
0.0097087,
-0.0082978625,
0.026839338,
0.013526652,
0.008598751,
-0.041161675,
-0.030597113,
-0.0005553918,
-0.0089665055,
-0.024940392,
-0.0021864632,
-0.01062474,
0.0062083523,
0.016288148,
0.0064323475,
0.0014852238,
-0.009019997,
-0.014990981,
0.000018688055,
0.015191574,
0.014937489,
0.017103894,
-0.032923993,
-0.0021262853,
-0.0012679147,
-0.029233081,
0.0031910997,
-0.012149247,
0.007335016,
0.018855738,
-0.01253706,
0.018187094,
0.02768183,
0.0047908286,
0.022292564,
-0.015579387,
-0.00550962,
-0.033218194,
-0.0018772158,
-0.033084467,
0.01188179,
-0.013305999,
-0.009628462,
-0.010511071,
-0.0116544515,
0.0070608724,
-0.0014902386,
-0.009153726,
0.02413802,
-0.0071544824,
-0.023870563,
0.001257885,
0.041857064,
-0.0000025955633,
0.013051915,
-0.017719045,
-0.016675962,
-0.02320192,
-0.025381695,
-0.02899237,
-0.013580143,
0.012610611,
0.020233143,
-0.019029586,
0.001919006,
-0.0052087307,
-0.032950737,
-0.021597175,
0.013486533,
0.005278938,
0.013921152,
0.021142498,
0.011888476,
-0.021931497,
-0.02535495,
-0.026050339,
0.04038605,
-0.0027982718,
-0.009274081,
0.014736896,
-0.0005654214,
-0.023148427,
0.018267332,
-0.009862487,
-0.00040055907,
-0.009307513,
-0.0372568,
0.004506655,
-0.00998953,
0.009300827,
0.010771842,
-0.0076492783,
-0.028296981,
-0.007709456,
-0.022172209,
-0.009180471,
-0.024405478,
-0.0057336153,
0.027414372,
0.0020961964,
-0.0035337794,
-0.022065226,
-0.0056466917,
-0.0033382012,
-0.011259952,
0.008999937,
-0.022760615,
0.020741312,
0.021089006,
-0.0013147197,
-0.017812654,
-0.0067232074,
-0.013058602,
-0.01587359,
0.005803823,
-0.001795307,
0.013580143,
0.019778466,
0.026224187,
0.020193025,
-0.02241292,
0.021583803,
0.015512522,
-0.028457455,
-0.0077428883,
-0.012851322,
0.01709052,
0.026571881,
-0.011567527,
0.040466286,
0.013687126,
-0.014763642,
-0.022252446,
0.015886962,
0.015980573,
-0.04846326,
0.006729894,
0.023215292,
-0.003807923,
0.0056901537,
0.03212162,
-0.16924697,
-0.008244371,
0.018467925,
-0.015846845,
0.013947898,
-0.004583549,
0.027026558,
0.0024204885,
-0.0275481,
-0.032094873,
0.006546017,
-0.014977608,
-0.016020691,
-0.019123195,
-0.0011676182,
0.012383272,
-0.023616478,
0.010430834,
0.042659435,
0.019765094,
0.042846657,
0.020968651,
0.0043896427,
-0.011500663,
-0.00044924466,
0.022105344,
-0.021891378,
0.017558571,
-0.0009386079,
-0.016421877,
-0.019497637,
0.008364727,
0.01960462,
0.017678926,
0.0030256105,
-0.00290024,
-0.0076960833,
-0.006927144,
-0.012697535,
-0.0018203811,
0.021302972,
0.040305812,
-0.01396127,
-0.0031693687,
-0.016956791,
-0.00270299,
0.04207103,
-0.013138839,
0.016328268,
-0.0077629476,
-0.014670032,
-0.035545073,
-0.005676781,
-0.010417461,
-0.016234657,
0.011293383,
0.0066764024,
0.029821487,
-0.012898128,
-0.008337981,
-0.0033950359,
-0.04057327,
0.011286697,
-0.0004952139,
-0.023736835,
-0.019631365,
-0.017866146,
-0.028323727,
-0.016234657,
0.011928595,
-0.029634267,
-0.009608403,
0.013279254,
-0.013613576,
0.030730842,
0.029393556,
-0.012089069,
0.0113669345,
-0.0075556682,
-0.021931497,
0.011173028,
0.022773987,
-0.02162392,
0.0044163885,
-0.024579324,
0.013279254,
0.015940454,
0.015860217,
0.019297043,
-0.019297043,
0.02110238,
-0.028377218,
0.013105406,
-0.035277616,
0.015325302,
0.006158204,
0.01368044,
0.004530058,
0.036293954,
-0.03030291,
-0.0021396582,
0.008351354,
-0.029981961,
0.018173723,
0.008411531,
-0.007709456,
-0.017291114,
-0.0018270676,
0.036828868,
-0.02520785,
-0.019230178,
-0.0010589637,
0.0036173598,
0.014683405,
-0.010537817,
0.021503566,
0.008946446,
0.0035070337,
-0.028457455,
-0.00882609,
0.06172914,
0.0029136129,
0.002119599,
0.0033448876,
-0.015485777,
-0.02843071,
-0.11575551,
-0.036909103,
0.027628338,
0.010384029,
-0.021276226,
0.0014150161,
-0.0009971142,
0.009681954,
-0.002392071,
0.037711475,
-0.0113669345,
-0.023268783,
-0.00968864,
-0.019470891,
0.036721885,
0.024967138,
0.003497004,
-0.029767996,
-0.011714629,
0.042418726,
-0.0072681517,
0.015459031,
0.015980573,
0.0042793164,
0.005833912,
-0.012985051,
-0.003774491,
0.025823,
0.0034769448,
0.025876492,
0.0275481,
-0.024565952,
-0.00074052234,
0.015672997,
-0.0011166341,
-0.022867598,
-0.0038915034,
0.00015326556,
0.009227276,
-0.036400937,
0.022118717,
0.016635843,
0.030971553,
0.007869931,
0.010711664,
0.0033448876,
-0.019470891,
0.014964235,
-0.038192898,
0.007054186,
-0.0034267965,
0.0023034757,
-0.007849871,
0.013352805,
0.0019056331,
-0.018855738,
0.014268846,
-0.007535609,
0.0036808809,
-0.019524382,
0.00504157,
0.004550117,
-0.0072948975,
0.005355832,
0.004329465,
0.0019607963,
-0.0055062766,
0.0033950359,
-0.0014233742,
-0.008946446,
-0.015004354,
0.032201856,
0.00070249324,
0.00016475786,
-0.028109761,
-0.0070274402,
-0.011567527,
-0.008739167,
-0.00428266,
0.0034836312,
-0.013045229,
-0.024057783,
-0.0007137766,
-0.0016456981,
0.024953764,
0.027213778,
0.0113669345,
0.018869111,
0.015659625,
-0.026879456,
-0.015057845,
0.0051084342,
0.0016089227,
-0.017866146,
-0.01234984,
0.0119419675,
0.007856558,
-0.01386766,
0.00987586,
-0.013065288,
-0.006178263,
-0.007228033,
-0.040359303,
0.008124015,
-0.0049446165,
0.017638808,
-0.0012328109,
-0.021864632,
0.04062676,
0.012543746,
-0.008525201,
0.01821384,
-0.03399382,
-0.009046743,
-0.024873527,
0.014670032,
-0.0187755,
-0.014563049,
0.0018437837,
0.025849747,
0.023028072,
0.0056132595,
-0.008150761,
0.016488742,
0.0147235235,
-0.009601716,
-0.0010213525,
-0.01160096,
0.008812717,
0.007803066,
-0.008558633,
-0.0016197881,
-0.015499149,
-0.0003437244,
0.02502063,
0.0069070845,
-0.028002778,
-0.01731786,
0.008578693,
0.013185644,
0.038460355,
0.029901724,
-0.0032913962,
-0.0328705,
0.009347632,
-0.008806031,
-0.010858766,
-0.0129115,
-0.011353562,
0.017237622,
-0.0052388194,
-0.010009589,
0.01643525,
0.00654936,
0.0044832528,
-0.021837886,
-0.037657984,
-0.0019624678,
-0.00016977268,
0.006505898,
-0.007849871,
-0.041108184,
0.028564438,
-0.012115815,
-0.008110642,
-0.012129188,
0.024525832,
-0.014910744,
-0.012570492,
0.0006431512,
0.014161863,
-0.014135118,
-0.026224187,
0.0059642973,
-0.004379613,
0.009213903,
0.013406296,
-0.0105043845,
-0.019083077,
0.023041444,
-0.00318107,
0.0140548805,
0.015285184,
-0.02256002,
-0.008144074,
0.02451246,
0.015820099,
0.0075891004,
-0.028350472,
0.0106448,
0.006094683,
0.0118483575,
-0.022453038,
0.019056331,
0.0033783198,
0.008057151,
-0.017933011,
0.020995397,
0.015418912,
-0.002064436,
0.020554092,
0.03573229,
-0.0020694507,
-0.005078345,
-0.012196052,
-0.03829988,
-0.03305772,
-0.007147796,
-0.0169033,
-0.045227025,
0.003334858,
0.0044030156,
0.019885449,
0.029848233,
0.0053290864,
-0.0002285924,
-0.018574908,
-0.0063989153,
0.00835804,
-0.026598627,
-0.0035939573,
0.0014568064,
0.0031242354,
0.018574908,
0.022011735,
-0.01225623,
0.021837886,
0.015044472,
0.043862995,
-0.019551128,
0.021022143,
0.005185328,
0.013687126,
-0.018481297,
0.0015320288,
-0.00006085698,
-0.021958243,
-0.012122502,
0.012831263,
0.013560085,
-0.0047440236,
0.06349436,
0.01045758,
-0.0010949032,
0.005743645,
-0.0064524068,
0.033539142,
0.0027782125,
0.014763642,
0.017331231,
-0.024378732,
0.024672935,
-0.014161863,
0.0214367,
-0.014950862,
-0.02334902,
0.014990981,
-0.0020326753,
0.023683343,
-0.0014952534,
-0.031827416,
0.026812593,
-0.0075556682,
0.022747241,
-0.00569684,
-0.0065694195,
0.006960576,
0.023803698,
-0.008037091,
-0.0066663725,
-0.0176923,
-0.0132926265,
0.0123230945,
-0.016662588,
-0.0108855115,
0.029099353,
-0.016301522,
-0.014362456,
-0.0076693376,
0.014924116,
-0.009153726,
0.001748502,
0.008558633,
-0.0116544515,
-0.024351986,
-0.037283543,
-0.015793353,
-0.011741375,
0.000049155722,
-0.028510947
] |
Ectopic expression of the four transcription factors Oct4, Sox2, c-Myc, and Klf4 is sufficient to confer a pluripotent state upon the fibroblast genome, generating induced pluripotent stem (iPS) cells. It remains unknown if nuclear reprogramming induced by these four factors globally resets epigenetic differences between differentiated and pluripotent cells. Here, using novel selection approaches, we have generated iPS cells from fibroblasts to characterize their epigenetic state. Female iPS cells showed reactivation of a somatically silenced X chromosome and underwent random X inactivation upon differentiation. Genome-wide | [
-0.03142066,
-0.007933848,
-0.02313274,
-0.03509252,
-0.044613138,
-0.00007714601,
-0.033413954,
0.015434939,
-0.018333089,
-0.018070813,
0.0074158525,
-0.004494754,
-0.006586405,
0.0018129825,
-0.034069646,
0.006865073,
0.027801251,
-0.0009286208,
-0.0060946373,
0.02866676,
-0.023958908,
0.007874835,
0.0066716443,
-0.008805915,
-0.022818008,
0.011723735,
-0.00085895375,
-0.030187963,
-0.010209091,
-0.016011946,
0.007658458,
0.012549904,
-0.020746028,
0.002721113,
-0.013441643,
-0.008517412,
-0.020260816,
-0.02801107,
0.008851813,
0.00021432863,
0.021165669,
0.009953372,
-0.011926998,
0.009448491,
0.0020162463,
-0.0042423136,
-0.007579775,
0.00063970743,
-0.0034620424,
0.02175579,
0.021808244,
0.0023735974,
-0.0035636744,
0.018949438,
-0.019657582,
-0.024194956,
0.010681188,
0.010628733,
0.015212005,
-0.0041308464,
-0.0062913443,
0.002145745,
-0.013041671,
0.01101559,
-0.0062323324,
0.014608771,
-0.0066421386,
0.014346494,
0.01723153,
-0.00018492504,
0.038449652,
0.009592743,
-0.019618241,
-0.012890863,
0.0028604472,
-0.008871484,
-0.011900771,
-0.00036780103,
-0.004996357,
0.005871703,
0.01674632,
-0.025571905,
-0.014346494,
0.024444118,
0.0058618677,
0.00792729,
0.0020703408,
0.03042401,
0.02137549,
-0.00068724493,
0.026122684,
0.036666177,
0.033859827,
0.011920442,
-0.019421535,
0.014910388,
0.0029604398,
0.016916798,
-0.003875127,
-0.026240708,
-0.0051012672,
0.027224243,
-0.00023072088,
-0.016431589,
-0.03663995,
0.025611246,
0.013428529,
0.00035653138,
0.022149203,
-0.0066224677,
-0.023316331,
0.018700276,
0.009959929,
-0.06247413,
0.038423426,
-0.01657584,
-0.002839137,
0.00479965,
-0.02334256,
-0.0013654742,
0.008327262,
0.02048375,
0.005471732,
-0.015907036,
0.01727087,
0.010248433,
-0.009540288,
-0.007979746,
-0.032076348,
0.004166909,
0.027958617,
-0.01598572,
0.01139589,
0.030896107,
-0.029715866,
-0.013330176,
-0.0049898,
-0.0038784056,
-0.018883869,
-0.027276698,
-0.010248433,
0.010622176,
-0.0057372865,
-0.0064093685,
-0.01205158,
-0.002640791,
0.0074158525,
-0.02465394,
0.028797898,
-0.0027620937,
-0.0126351435,
0.0009097697,
0.02524406,
0.008569866,
-0.0056258193,
0.0105697205,
0.032128803,
0.018477341,
-0.01515955,
0.00006239299,
-0.00951406,
-0.011002476,
0.008733789,
0.02344747,
-0.0074224095,
0.018044585,
0.006930642,
0.009677983,
0.012222059,
-0.002340813,
-0.015697215,
0.01723153,
-0.047183443,
0.018385544,
0.008760016,
0.007651901,
-0.020575548,
0.002678493,
-0.022306569,
-0.017716741,
-0.019500216,
0.031158382,
0.01830686,
-0.0096451985,
-0.013874398,
0.0006864253,
0.020313272,
-0.028220892,
-0.003283367,
-0.02355238,
0.0061897123,
0.010976248,
0.0065273927,
-0.00372104,
-0.6370158,
-0.03084365,
0.039341394,
-0.024299867,
0.025257174,
0.047052305,
-0.004442299,
-0.026306277,
-0.015343143,
0.02634562,
-0.026516099,
-0.0010310723,
0.010858225,
-0.019447763,
-0.0055241873,
-0.031918984,
-0.015880808,
-0.0021719728,
0.006924085,
0.011579483,
-0.013599008,
-0.011218853,
-0.023421243,
0.03378114,
-0.0016187343,
0.024050705,
0.02924377,
-0.023880225,
-0.024155615,
0.034043416,
-0.020431297,
0.031053472,
-0.00913376,
-0.014989071,
0.048809554,
0.008405944,
-0.017585602,
0.032889403,
0.032443535,
0.04831123,
-0.01329739,
0.0083534885,
0.015946377,
0.0064880513,
-0.008602651,
0.02448346,
-0.0035702314,
0.013585894,
0.0111270575,
0.015408712,
0.011658166,
0.002998142,
-0.03325659,
0.00564549,
0.017690513,
0.013979308,
0.0048848893,
0.007946962,
0.026804602,
-0.013979308,
0.0014867767,
0.023631062,
-0.02748652,
-0.010032055,
0.006071688,
0.022188546,
0.012359754,
-0.011035261,
0.009048521,
-0.023749087,
0.014385836,
0.037898876,
-0.011520471,
0.006271674,
0.0064454316,
0.025388312,
-0.0046455627,
0.005953664,
0.01262203,
0.0006712625,
0.012504006,
-0.022280341,
-0.011520471,
0.0087075615,
0.018634707,
0.002881757,
-0.007783039,
0.03128952,
-0.0103926845,
0.002786682,
0.018241292,
-0.0015859499,
0.003625965,
-0.041308463,
-0.031551797,
0.0029751929,
0.0017211859,
0.01091068,
-0.00932391,
-0.019696923,
-0.02082471,
-0.0039210254,
0.014176015,
0.016772548,
0.018739616,
0.0032161588,
-0.023119625,
-0.006091359,
0.027538974,
-0.03545971,
0.0028866746,
-0.010123852,
0.0006901136,
-0.018057698,
-0.00790762,
-0.024142502,
0.013081013,
0.008471513,
-0.020221476,
-0.009841905,
0.016825002,
-0.021650879,
0.0019228106,
0.028037298,
0.0027981566,
0.01896255,
-0.009743552,
-0.0035210545,
-0.004579994,
-0.005389771,
-0.009900917,
-0.020208362,
0.017257757,
-0.02530963,
0.018123267,
-0.013979308,
0.016877457,
0.002683411,
0.022188546,
-0.03097479,
-0.027565202,
-0.0018572416,
0.0068322886,
-0.022018066,
-0.004976686,
-0.011363106,
-0.010969692,
0.0024178564,
0.012877749,
0.0023080283,
0.012281071,
-0.0020621447,
-0.0027407836,
0.006845402,
0.020024769,
-0.020942735,
-0.005488124,
-0.040390495,
-0.00040837185,
-0.009605857,
-0.020588662,
0.029951913,
0.0042160857,
-0.009487833,
0.009035407,
-0.009264898,
-0.018700276,
0.004399679,
-0.011782747,
-0.026306277,
0.0009163266,
0.008419058,
-0.022175431,
0.0017785588,
-0.011022147,
0.0053209234,
0.0135203255,
-0.0029538828,
-0.0052291267,
-0.013690804,
-0.012864635,
-0.027302926,
-0.0107402,
-0.0051176595,
0.03698091,
0.012694156,
0.018516682,
0.0045242603,
0.0066093537,
0.0076977992,
-0.017533148,
0.0025866965,
-0.0038423426,
0.031578023,
0.02372286,
-0.0133695165,
0.011415561,
0.009782893,
0.0017490528,
0.014516974,
0.013290834,
-0.02289669,
0.010845111,
-0.023014715,
0.023408128,
-0.028535623,
0.013428529,
-0.030030597,
0.00017365537,
0.012248287,
0.0029161808,
0.011513914,
-0.008655107,
-0.0016547974,
0.00055364816,
-0.018634707,
-0.004537374,
-0.017690513,
0.0010154997,
-0.0035505607,
-0.0075142058,
0.0014621884,
0.0211001,
0.019880516,
0.0014507138,
0.00953373,
0.000970421,
0.011658166,
0.021519741,
-0.007127349,
0.005334037,
0.012648257,
0.011041817,
-0.004779979,
0.024771964,
0.00877313,
0.013376073,
-0.016549611,
0.036718633,
-0.013979308,
0.010805769,
0.020746028,
0.006655252,
0.010838553,
-0.01585458,
-0.007920734,
0.033676233,
-0.005484846,
-0.01148113,
0.0057536787,
-0.03629899,
0.020759141,
-0.021703335,
0.011068045,
0.021572197,
-0.012615473,
-0.004973408,
0.0195789,
0.00811744,
0.026463643,
-0.004530817,
-0.02209675,
0.0058258045,
-0.008956724,
-0.0015023494,
0.009887803,
0.006983097,
-0.0051406086,
-0.027565202,
-0.0081764525,
-0.03246976,
0.008878041,
0.013690804,
-0.0049439017,
0.009487833,
-0.0049340664,
0.0030456795,
0.016693864,
0.015487395,
-0.0054684537,
-0.010261547,
-0.022686869,
0.022319684,
0.019998541,
0.007258487,
0.017467579,
-0.025165377,
-0.024732621,
0.01412356,
0.0058913734,
0.008609208,
-0.0139137395,
-0.0012466303,
0.0004848007,
-0.0040029865,
-0.0111401705,
0.013533439,
-0.013133468,
0.023919566,
-0.02010345,
0.018293748,
-0.030555148,
-0.003332544,
-0.0036161297,
0.033125453,
0.0056651607,
-0.008733789,
-0.011382776,
-0.011513914,
-0.023250762,
-0.0045996644,
-0.013494098,
-0.0040816693,
0.002750619,
-0.009763222,
-0.010235319,
0.0071535767,
-0.00042701804,
0.039787263,
-0.0070945644,
-0.006170042,
-0.03393851,
-0.00697654,
-0.003363689,
0.02247705,
0.03241731,
-0.01308757,
0.006996211,
-0.008058429,
0.0010277939,
-0.005589756,
-0.004055442,
0.0030997738,
-0.025322743,
0.015789011,
0.008497741,
0.0015564439,
-0.016064402,
-0.0013482623,
0.011074602,
-0.018726503,
-0.027381608,
-0.026804602,
-0.015369371,
-0.0064814943,
0.018674048,
0.014490746,
0.032600902,
0.005304531,
-0.008805915,
0.0089108255,
0.02693574,
-0.025703043,
-0.01357278,
-0.018398657,
0.017179074,
0.009927144,
0.0003464911,
0.010628733,
-0.03981349,
0.012104035,
0.0060946373,
-0.0118745435,
0.021886928,
-0.003180096,
0.02313274,
0.0129892165,
-0.0131662525,
0.008327262,
0.0021178783,
-0.011527028,
0.0012441715,
-0.001418749,
-0.021218125,
0.011166398,
-0.02801107,
-0.030817425,
-0.008222351,
0.002006411,
-0.010635289,
0.01016975,
-0.024116274,
0.0026162027,
-0.0026735754,
-0.0059077656,
-0.01553985,
0.01139589,
-0.0013097405,
-0.012018795,
-0.024286753,
0.0066716443,
-0.016300451,
-0.021362375,
-0.007815823,
0.016929913,
-0.03753169,
-0.035407253,
0.01902812,
0.018031472,
0.038239833,
0.008327262,
-0.0074879783,
-0.0061962693,
0.013625235,
-0.0056422115,
-0.026883285,
-0.0010163193,
-0.031132156,
0.007914177,
0.0050258627,
-0.00513733,
-0.00820268,
-0.00047373594,
0.0033161514,
0.041911695,
-0.015369371,
-0.009330467,
0.0013957998,
-0.007887949,
0.025126036,
0.030083051,
0.009697653,
0.0063208505,
-0.010891009,
-0.0018539631,
-0.03509252,
-0.009304239,
-0.038633246,
-0.021126328,
0.0034095873,
-0.0019687088,
-0.0024342486,
-0.037715282,
-0.021388603,
0.019710038,
0.0068913004,
0.017795423,
-0.007946962,
0.026988195,
0.03097479,
-0.02120501,
0.022752438,
0.0030456795,
-0.016038174,
0.00005706551,
-0.02589975,
0.027355382,
0.0135465525,
-0.0133564025,
0.00809777,
0.014516974,
-0.01101559,
-0.025152264,
0.00084665953,
-0.0218607,
0.036141627,
-0.009651755,
-0.009002622,
-0.010858225,
0.008084656,
-0.009015736,
0.022726212,
0.02137549,
-0.009297682,
0.0030571541,
0.007887949,
-0.0015916872,
-0.017808536,
0.009684539,
-0.039079115,
-0.0040456066,
0.017874107,
0.020955848,
-0.0033210693,
-0.0049111173,
0.019434648,
-0.006376584,
-0.014923502,
-0.014962843,
-0.035433482,
-0.009684539,
-0.039236482,
0.05649424,
0.033754915,
0.027879933,
0.026253823,
0.01327772,
0.011245081,
-0.004068556,
-0.0034194228,
0.0074945353,
0.024706393,
-0.03448929,
0.018595364,
-0.0013072817,
0.008746902,
0.025860408,
-0.030555148,
0.0031260015,
0.04209529,
-0.032522216,
-0.013041671,
0.01477925,
-0.02382777,
-0.03501384,
-0.0034620424,
0.012169604,
0.009225557,
-0.027984845,
0.015461167,
-0.005507795,
-0.0073043853,
-0.0045570447,
0.0068388456,
0.035276115,
-0.018765844,
0.026083343,
-0.0012695795,
-0.0021982002,
-0.037977558,
-0.001583491,
-0.00272767,
-0.0010827079,
0.022988487,
0.0011466377,
0.027827479,
0.0020555877,
0.000042747906,
-0.0038488996,
0.022568846,
-0.010628733,
-0.017152848,
-0.014267812,
-0.021362375,
-0.0038193935,
-0.012464665,
-0.013717032,
-0.022804894,
-0.014425177,
0.0076781283,
-0.03947253,
0.026044002,
-0.0013244936,
-0.015448053,
0.022844234,
-0.01395308,
0.028876582,
-0.008622322,
0.019054348,
0.03401719,
0.003188292,
-0.023814656,
-0.025847295,
-0.01374326,
0.009238671,
0.056389328,
0.016156198,
-0.0002919869,
-0.03042401,
0.0042259214,
0.006058574,
-0.01892321,
-0.016838117,
-0.015408712,
-0.013494098,
-0.008320704,
0.0072191455,
0.027171789,
-0.02725047,
0.0035735099,
-0.015736558,
0.014530088,
-0.0065470636,
0.0015252986,
-0.030502694,
0.01384817,
-0.008071543,
0.010864781,
0.021152556,
-0.007868279,
-0.019854289,
-0.023303218,
-0.0041406816,
0.020129679,
-0.005868424,
0.03225994,
-0.0226213,
0.0028440547,
0.0120646935,
-0.002648987,
-0.008019087,
0.013244935,
0.013415415,
0.036587495,
0.0065929615,
0.0040751128,
-0.00405872,
0.018333089,
0.01471368,
-0.018241292,
-0.0042783762,
-0.0021916435,
-0.014989071,
0.0048324345,
0.032076348,
0.005596313,
0.009487833,
-0.0010081232,
-0.020785369,
-0.005868424,
-0.03936762,
-0.028404485,
0.007579775,
-0.02911263,
0.0028932316,
0.0013064621,
0.040495407,
0.022765553,
0.020287044,
0.017795423,
0.003888241,
0.017074164,
-0.014044877,
0.010451697,
0.01027466,
0.008301034,
-0.019119916,
0.012163047,
-0.0109631345,
-0.02866676,
0.0019064184,
-0.02437855,
-0.024680167,
0.0007290452,
0.0050094705,
0.03173539,
0.00811744,
-0.011664723,
0.013756374,
0.007435523,
0.0071535767,
-0.0139006255,
-0.015867695,
-0.019369079,
-0.010156636,
-0.001469565,
0.010779542,
-0.007763368,
-0.014031763,
-0.010556607,
-0.0048160423,
0.020601775,
-0.014923502,
-0.009566516,
0.004380008,
-0.0063733053,
-0.021690222,
0.0008040397,
0.0033800814,
-0.0073961816,
-0.01564476,
-0.002086733,
0.0018424885,
-0.0028260234,
-0.029506044,
0.020405069,
0.0005614344,
0.012359754,
-0.011258195,
0.0013187563,
-0.024601484,
-0.032758266,
-0.022345912,
0.021532856,
-0.0072781574,
0.04776045,
0.028168436,
-0.007750254,
-0.020916507,
-0.014254698,
-0.049229197,
-0.037007138,
-0.008255135,
0.012340084,
0.004475083,
-0.0046094996,
-0.0109631345,
-0.025912864,
-0.01158604,
0.006058574,
-0.004261984,
-0.03273204,
0.016602067,
0.011723735,
0.0111139435,
0.00659624,
-0.02634562,
-0.01609063,
0.024863759,
-0.013081013,
-0.0011802418,
0.017047936,
-0.009927144,
0.038318515,
-0.008904268,
0.030948563,
0.014490746,
0.017900333,
0.044849187,
-0.036587495,
0.0017670842,
0.021808244,
0.010241875,
-0.007573218,
0.008137112,
0.0062224967,
0.0060356255,
-0.00034403228,
0.0068913004,
-0.018333089,
-0.0012351557,
-0.019696923,
0.03218126,
-0.009068191,
0.006071688,
0.013225265,
0.0131662525,
-0.0045177033,
-0.013310504,
0.0063962545,
-0.007638787,
0.0022359025,
0.03446306,
-0.013330176,
-0.010097624,
0.004681626,
-0.019500216,
-0.01799213,
-0.008104327,
0.0027096383,
-0.023972021,
-0.02427364,
0.012163047,
0.0018916653,
-0.017900333,
-0.020588662,
-0.008982951,
-0.010432025,
-0.021126328,
-0.019762492,
-0.009192772,
-0.0030161734,
0.000025087822,
0.0037046478,
-0.010195977,
0.0018539631,
0.0014171097,
0.0011154924,
-0.0063962545,
0.022490162,
0.1869503,
-0.01008451,
0.0043603377,
0.009035407,
0.0036554711,
-0.012648257,
0.010353343,
-0.01647093,
-0.013231821,
0.004268541,
0.016261108,
0.006930642,
0.007815823,
-0.0047176885,
0.021257466,
-0.01346787,
-0.006691315,
0.003524333,
-0.022975374,
-0.0096451985,
0.026686577,
-0.01329739,
0.022922918,
0.012307299,
0.022004953,
0.0037177615,
-0.029401135,
0.019801835,
0.015500508,
0.016811889,
-0.022568846,
0.013402301,
0.008189566,
0.0037898875,
0.012956432,
0.0094681615,
0.011349992,
-0.017585602,
0.012031909,
-0.027302926,
0.008760016,
0.0011064766,
-0.0071011214,
0.0019015006,
-0.003399752,
0.0036882556,
0.0010704137,
-0.0070224386,
0.004983243,
-0.002078537,
-0.020077223,
0.0064224824,
-0.0020982076,
0.018516682,
0.0032407471,
-0.007835494,
0.00790762,
0.019867403,
-0.008255135,
0.0071994746,
0.0023113068,
0.010904122,
-0.033099223,
0.016615182,
-0.018569138,
0.0120646935,
-0.0040029865,
-0.0021178783,
0.030083051,
-0.014530088,
-0.0028342195,
0.01788722,
-0.0129761025,
0.015670989,
0.009317353,
-0.043590263,
0.04374763,
0.009671425,
0.030030597,
0.023395015,
0.022424594,
-0.0014433373,
-0.03795133,
0.021454172,
0.0120646935,
-0.044455774,
0.038449652,
0.0016318482,
-0.034935158,
-0.008609208,
0.007324056,
-0.023644177,
-0.012871192,
-0.010235319,
0.0062192185,
-0.005275025,
-0.010373014,
0.0067208214,
-0.019211713,
-0.0036390787,
-0.034856472,
0.06609354,
0.009638641,
0.013638349,
0.004484919,
0.016444702,
0.015343143,
-0.015933264,
-0.005061926,
-0.005068483,
0.023880225,
-0.007048666,
0.01651027,
-0.017179074,
-0.0013343289,
0.029689638,
-0.0055569718,
-0.038475882,
0.032128803,
0.0135203255,
-0.01727087,
-0.021113213,
0.006563456,
0.011572926,
-0.019001892,
0.0011761438,
0.004773422,
0.017559376,
-0.022293456,
-0.018149495,
-0.007704356,
-0.00405872,
0.018057698,
0.009396036,
0.012163047,
0.00015234544,
-0.00087288715,
-0.007651901,
-0.03477779,
0.021624653,
-0.0044029574,
-0.0010638568,
0.0073306127,
0.007120792,
-0.009146874,
-0.012438437,
0.029033948,
0.029794548,
0.0011884379,
-0.015513622,
-0.025821067,
-0.010884452,
0.008123998,
0.00517995,
0.02814221,
-0.0124449935,
0.0037898875,
-0.011428675,
-0.0070945644,
0.019146144,
-0.027434064,
0.016143085,
-0.014294039,
-0.006166763,
-0.0077895955,
-0.016221767,
-0.16387,
-0.008130554,
0.023040943,
-0.03173539,
0.029715866,
0.0061765984,
0.0014359609,
-0.016247995,
-0.00026248084,
-0.0076125595,
0.018726503,
0.010536936,
-0.04141337,
-0.015579191,
0.0088977115,
0.019657582,
-0.00940915,
0.05004225,
0.013599008,
0.009573072,
0.010451697,
-0.013533439,
0.008445285,
-0.0032571394,
0.014044877,
-0.010307445,
0.023709746,
-0.021309922,
-0.016169311,
-0.035066295,
-0.0024309703,
-0.005553693,
0.023604836,
-0.0061143083,
0.014766136,
-0.012208945,
-0.0051209377,
-0.0009228835,
0.010871338,
0.025427653,
0.025493221,
-0.009973043,
-0.0068257316,
0.0062847873,
-0.0018277356,
0.03380737,
-0.012549904,
0.003078464,
0.015972605,
0.005852032,
0.0011318846,
0.00084747915,
-0.00970421,
0.009356694,
0.015684102,
0.0033800814,
0.019644469,
0.0059930054,
-0.01055005,
-0.0048193205,
-0.0039243037,
-0.00247359,
0.035171203,
-0.007940404,
-0.0028784785,
-0.021008303,
0.006550342,
0.013677691,
-0.034095872,
0.0027030816,
-0.013821943,
-0.015238233,
-0.002276883,
-0.014516974,
0.023906453,
0.0012540069,
-0.013599008,
0.006632303,
-0.010602505,
-0.016969254,
-0.044901643,
0.031997666,
-0.016156198,
-0.02600466,
-0.01934285,
0.012569575,
0.0207198,
0.023670405,
-0.02659478,
-0.012405653,
0.016667636,
-0.016943026,
-0.0011892575,
0.007828937,
0.026201367,
0.010373014,
-0.014556315,
-0.0036882556,
-0.0142809255,
0.0061765984,
0.024680167,
-0.000034321267,
-0.0045504877,
0.00725193,
0.05943173,
-0.0103599,
-0.020667344,
0.018031472,
0.06756228,
-0.012543348,
-0.0066257464,
0.010104181,
-0.0034456502,
0.01695614,
0.0035538392,
0.042908344,
0.002793239,
0.0153955985,
0.009258341,
-0.028614307,
0.08120064,
0.014923502,
0.003232551,
0.050855305,
-0.005261911,
-0.007894506,
-0.13449511,
-0.010943464,
-0.0000024812482,
0.026529212,
-0.0049570156,
0.019133031,
-0.00078027096,
0.022831121,
-0.0050324197,
0.020129679,
-0.0015982441,
-0.031446885,
0.012300742,
-0.009094419,
0.0062782303,
-0.0021572197,
0.00030796934,
0.0051111025,
-0.027329154,
0.04033804,
0.0079863025,
0.009212443,
-0.02044441,
-0.013599008,
0.010799212,
0.027381608,
-0.03784642,
0.030214189,
0.021073872,
0.024063818,
0.008543639,
-0.024850646,
0.023054056,
0.017415123,
-0.01357278,
-0.0006171681,
-0.00025571906,
-0.023670405,
0.032758266,
-0.02475885,
-0.0029637183,
-0.017493805,
0.006697872,
-0.011376219,
0.0016916798,
-0.010327116,
-0.031237066,
0.0051537226,
0.020352613,
-0.018241292,
-0.052402735,
-0.037190728,
-0.026673464,
0.00034321265,
0.010838553,
-0.010477924,
0.003963645,
0.019473989,
-0.0027063598,
-0.004452134,
0.0036456357,
-0.012982659,
-0.018503569,
-0.016733205,
0.004865219,
-0.014897274,
-0.028771672,
-0.037767738,
0.031237066,
-0.02285735,
-0.006383141,
0.0035767884,
-0.00606841,
0.011559812,
-0.022214772,
0.008714118,
-0.00017119653,
-0.0188183,
0.00016853279,
-0.037426777,
-0.013703918,
-0.017624944,
0.0042128074,
-0.00008723749,
0.01598572,
0.009625527,
0.010432025,
-0.02099519,
-0.009179658,
0.01091068,
-0.019618241,
0.03732187,
-0.003589902,
-0.02068046,
-0.011697507,
-0.0017326605,
-0.0037439892,
0.0032358295,
0.019710038,
0.018293748,
-0.009664869,
-0.02617514,
-0.050199617,
0.0153955985,
0.007238816,
-0.017572489,
-0.017690513,
-0.0072781574,
-0.0049799643,
-0.0035112193,
0.0016187343,
0.0036587494,
-0.02182136,
0.0070945644,
-0.029532272,
-0.0038488996,
-0.027014423,
-0.013507212,
0.03632522,
-0.0007765827,
0.011953226,
0.02441789,
-0.002181808,
-0.0037636599,
0.007835494,
-0.0002464984,
-0.0071076783,
-0.0030046988,
-0.02835203,
0.03241731,
-0.017979017,
-0.022831121,
0.00034772055,
-0.046134338,
-0.028325802,
0.007238816,
-0.011546698,
-0.0040226574,
0.0037308754,
0.03097479,
0.020641116,
0.02431298,
-0.0043964004,
-0.027040651,
0.016051289,
0.010241875,
-0.004865219,
0.011356548,
-0.021178782,
0.006648695,
0.004537374,
-0.0124449935,
0.028299576,
0.0017785588,
0.004347224,
0.0010671353,
-0.009035407,
-0.018503569,
-0.008825585,
-0.008078099,
0.0056094266,
-0.01357278,
0.016116858,
0.02010345,
0.0017851157,
0.0017261036,
-0.023473697,
-0.019762492,
-0.02645053,
-0.0055045164,
0.0087206755,
-0.031604253,
-0.026044002,
0.031446885,
0.021677107,
0.0051897853,
0.011835203,
-0.008025644,
-0.018870754,
0.0061831553,
-0.012687599,
0.019369079,
0.0049242307,
0.005458618,
-0.009081305,
-0.0027752074,
0.038213607,
-0.0046881824,
-0.025296515,
0.02659478,
-0.0063929763,
0.0006368388,
-0.008504298,
-0.0052422406,
-0.0051012672,
0.0043275533,
0.0199592,
0.0010032055,
-0.008825585,
0.027198017,
0.0040816693,
0.023027828,
-0.0030587933,
-0.0054159984,
0.019710038,
-0.003989873,
-0.023958908,
0.0150284115,
-0.024234297,
-0.038659476,
-0.018018357,
-0.003963645,
-0.007455194,
0.022595072,
-0.0128252935,
-0.0015384124,
-0.026398074,
0.011802418,
-0.0026030887,
-0.0111139435,
-0.001780198,
0.039551213,
0.014923502,
0.00847807,
0.0129761025,
-0.004494754,
0.0044685267,
-0.0020326385,
0.022359025,
-0.0000564508,
0.023906453,
-0.006150371,
0.03249599,
0.037269413,
-0.017716741,
-0.016877457,
-0.008537082,
-0.009927144,
0.0037702168,
0.023840884,
-0.009048521,
0.07842051,
-0.0016564366,
-0.026791489,
0.00579302,
-0.013113798,
0.028325802,
0.0026653793,
0.019355966,
-0.026673464,
-0.022332797,
0.033545095,
-0.037190728,
0.024142502,
-0.025650587,
0.0057176156,
0.015225119,
-0.011540142,
0.0107402,
-0.016838117,
-0.0008032201,
-0.003976759,
-0.026424302,
0.016208654,
0.019998541,
-0.044350863,
-0.0012040106,
0.04820632,
-0.008464957,
0.0032653355,
-0.005550415,
0.003566953,
-0.0070224386,
-0.034935158,
-0.0035538392,
0.013048229,
0.0004794732,
-0.013264606,
-0.016143085,
0.041623194,
0.013730146,
-0.01574967,
-0.007468308,
0.0022195103,
-0.004347224,
0.0064388746,
-0.012543348,
0.0019506774,
-0.0044914754,
-0.014674339
] |
This review summarizes our current understanding of exocrine pancreas development, including the formation of acinar, ductal and centroacinar cells. We discuss the transcription factors associated with various stages of exocrine differentiation, from multipotent progenitor cells to fully differentiated acinar and ductal cells. Within the branching epithelial tree of the embryonic pancreas, this involves the progressive restriction of multipotent pancreatic progenitor cells to either a central "trunk" domain giving rise to the islet and ductal lineages, or a peripheral "tip" domain giving rise to acinar cells. This review also discusses the soluble morphogens and other | [
-0.003977482,
-0.008290256,
0.016869783,
-0.033055834,
-0.008612399,
0.002590294,
-0.016330687,
0.010821381,
-0.010012736,
-0.014187449,
0.018618561,
0.012557009,
-0.011202693,
0.008060154,
-0.018263545,
0.0104466425,
0.030583879,
-0.0055849105,
-0.024272501,
0.013977069,
-0.023207458,
-0.015660103,
0.00058840436,
-0.029821254,
-0.0052923523,
0.0024703122,
0.00030652908,
-0.03279286,
-0.005663803,
-0.010525535,
0.007179191,
0.024430286,
0.011551133,
0.0014948429,
-0.003431811,
0.011643175,
-0.008684717,
-0.011445944,
0.011866703,
0.0013493855,
0.0057131103,
0.0019394334,
-0.010827955,
-0.0021974766,
-0.020222701,
0.0051115574,
-0.010847678,
-0.010420346,
-0.0031113115,
0.02753338,
-0.013214445,
0.013299911,
-0.012879153,
-0.01639643,
-0.027349299,
0.0020692768,
0.0011455806,
0.029216414,
-0.0052792034,
0.0029321604,
0.0035731595,
-0.0026593248,
-0.005999095,
-0.0015129223,
-0.009434193,
0.033844758,
-0.018145207,
-0.0018112336,
0.009066029,
-0.00037247804,
0.036211524,
0.0062949406,
-0.00023441669,
-0.006975386,
0.015738996,
0.0055947723,
-0.002738217,
-0.03308213,
-0.0072580827,
0.025469033,
0.009171219,
-0.023220606,
-0.013385378,
0.033634376,
0.013451121,
-0.016133456,
-0.0033660675,
0.0003291284,
-0.018079463,
0.007369847,
0.010518961,
0.0227867,
0.041733976,
0.015568062,
0.0057328334,
-0.010012736,
0.004523153,
0.03389735,
-0.000769199,
-0.023720257,
-0.021511275,
0.02053827,
0.00042856546,
-0.017763894,
-0.027875246,
0.02691539,
0.021248301,
0.0010025884,
0.020498825,
-0.014174299,
-0.019091913,
0.022510575,
-0.0029025758,
-0.028033031,
0.044994853,
-0.02611332,
0.03663228,
-0.0031228166,
-0.003579734,
-0.009020009,
0.014910627,
0.022997078,
0.022944484,
-0.037894554,
0.019381186,
-0.006153592,
0.004674363,
-0.0042305947,
-0.0008061797,
0.0013617123,
0.010512386,
-0.020880137,
0.017566664,
0.033871055,
-0.011570857,
-0.015094709,
-0.02339154,
0.0016707068,
-0.0047006607,
-0.043206632,
0.011012037,
0.018539669,
-0.0016205774,
-0.0009171219,
-0.020985326,
0.0072252112,
0.03055758,
0.0022434972,
0.0138455825,
0.019854538,
0.019946579,
-0.01761926,
0.009256685,
-0.01943378,
0.018079463,
0.02479845,
-0.0013230881,
0.013043512,
-0.013582608,
0.010933145,
0.007764308,
-0.013503715,
-0.0035501493,
0.020064918,
0.028401194,
0.036474496,
0.025035126,
0.009355301,
0.010111351,
0.0037243695,
-0.00260673,
0.0026889094,
-0.032240614,
0.00016374241,
0.008822778,
0.00475983,
0.006692689,
0.012727942,
-0.03865718,
-0.008342851,
-0.0093027055,
0.004575748,
-0.015397129,
0.0035304262,
-0.018539669,
-0.008224512,
0.01032173,
-0.002187615,
0.0007819368,
-0.013635203,
-0.0030981626,
0.012596455,
0.016422728,
-0.009677444,
-0.637449,
-0.015817888,
0.0048288605,
-0.022168709,
-0.000928627,
0.03834161,
0.0046414915,
-0.016738296,
-0.031793557,
-0.019657308,
-0.006041828,
0.008605825,
0.020709204,
-0.017343137,
-0.011774662,
-0.033345107,
-0.014897478,
-0.027954139,
0.0136089055,
-0.002511402,
-0.014095407,
-0.003272383,
-0.023299498,
0.014424125,
-0.005325224,
0.010466366,
0.028348599,
-0.00435222,
0.0033216905,
0.0077248616,
-0.025863495,
-0.014055962,
-0.011419646,
-0.012011338,
0.039814267,
0.01955212,
-0.010755638,
0.011906149,
-0.0054435623,
0.05527714,
0.0104466425,
0.002207338,
0.007784031,
0.0050556753,
-0.020367337,
0.0115248365,
0.02236594,
0.00050745765,
0.0038854412,
-0.019867687,
-0.0024374404,
-0.0041911486,
-0.033423997,
-0.008881947,
0.0029140809,
-0.012136251,
0.021406084,
-0.014871181,
-0.006002382,
-0.0009541026,
0.02399638,
0.026652416,
-0.03673747,
0.006623658,
-0.0019492949,
0.0110843545,
-0.0019345026,
-0.009887823,
-0.0049241884,
-0.0040991073,
0.007152893,
0.004394953,
-0.008684717,
0.011255288,
0.016580513,
0.037316013,
0.0043456457,
-0.0127673885,
-0.012063934,
0.009927269,
0.028979737,
0.009263259,
-0.0035337133,
0.014647652,
0.02074865,
-0.0038591437,
-0.001100382,
0.0059925206,
-0.00870444,
0.008960839,
-0.0018145207,
0.021235151,
0.0005958005,
-0.042996254,
-0.0064264275,
0.01993343,
-0.004371943,
0.014687099,
-0.012142825,
-0.035448898,
0.004260179,
0.0018030156,
-0.0014447136,
-0.0047894143,
0.026665565,
0.009933843,
-0.03726342,
0.010374325,
0.046362318,
-0.028033031,
-0.010249413,
-0.015988821,
-0.025574224,
-0.009230388,
0.008014133,
-0.01831614,
-0.0028762782,
0.0048321476,
-0.01508156,
-0.019486375,
0.0010436781,
-0.010288859,
0.0075933747,
-0.008007559,
-0.009184368,
0.0032181446,
0.011215842,
-0.020459378,
0.012221717,
0.007961539,
0.0010502525,
-0.020774947,
-0.003152401,
-0.019578416,
0.017040716,
0.015462873,
0.010604427,
-0.0052824905,
-0.0048157116,
-0.03986686,
-0.017934827,
-0.0072580827,
0.009309281,
0.0007018119,
-0.021406084,
-0.0015671608,
-0.0013395239,
0.011603729,
0.010854253,
0.0044902815,
0.0056243567,
0.0012433741,
-0.0048288605,
-0.00041397862,
0.044600394,
0.0068570473,
0.022050371,
-0.026139617,
0.01174179,
-0.01139335,
-0.0121625485,
0.018894684,
-0.011544559,
0.010249413,
-0.012169123,
-0.0070740012,
-0.0067387093,
0.0038755797,
0.032529887,
-0.030978339,
0.0010477871,
0.0027299991,
0.0048485836,
0.00941447,
-0.010735914,
-0.015107857,
0.012057358,
-0.016028266,
-0.008211364,
0.003351275,
0.011761513,
-0.007336975,
0.0010699756,
0.008408594,
0.04391666,
-0.0049603474,
0.04018243,
0.012714794,
-0.005252906,
0.028374897,
-0.0121625485,
0.017093312,
-0.0012696715,
0.038999047,
-0.0077708825,
-0.02700743,
0.0034679698,
0.0333977,
-0.011465667,
0.03794715,
0.019907134,
0.00900686,
0.012280887,
-0.0013625341,
0.01831614,
-0.022812996,
-0.00665653,
-0.010486089,
0.0066335197,
-0.0035534364,
-0.0035731595,
-0.016264943,
-0.006521756,
-0.0022533587,
0.0013230881,
0.0027727324,
0.013530013,
-0.017027568,
-0.013740392,
-0.012675348,
-0.005377819,
-0.0039840564,
0.004914327,
0.009789208,
-0.020012323,
0.013516865,
0.007014832,
-0.0021530997,
-0.012958045,
-0.037237123,
0.006771581,
0.003104737,
-0.00073427276,
-0.01863171,
0.0062522073,
0.031819858,
0.002374984,
-0.0031228166,
0.008119322,
-0.0006007313,
0.0071923393,
0.008244235,
-0.011353903,
0.008316553,
-0.007895795,
-0.012662199,
0.020275297,
0.009605126,
-0.008342851,
-0.0003324156,
-0.007481611,
0.018750047,
-0.0043226355,
0.0107819345,
0.014161151,
-0.00738957,
-0.00070140103,
-0.0007470106,
0.020012323,
0.016619958,
-0.004220733,
-0.022089817,
0.010696468,
-0.016751446,
0.005709823,
0.016435876,
-0.00038911938,
-0.023785999,
-0.004243743,
-0.007330401,
-0.0056177825,
-0.0040793843,
0.034134027,
-0.027244108,
0.0075802263,
0.017119609,
0.0044902815,
-0.0107819345,
0.01006533,
0.012182271,
-0.0019345026,
-0.020801244,
0.02570571,
0.03352919,
-0.00637712,
-0.008947691,
-0.00239142,
-0.019986026,
-0.0087307375,
0.018040018,
0.016514769,
0.0054632854,
0.016264943,
0.00012409086,
-0.0036126056,
-0.01842133,
0.0069096424,
-0.011150098,
0.014161151,
-0.014226895,
0.011156673,
-0.007652544,
-0.006031967,
-0.0016197556,
0.041655086,
0.020604014,
-0.014831735,
-0.010025884,
-0.014187449,
-0.015239344,
-0.043443307,
-0.022839293,
-0.010703042,
-0.004237169,
0.020354189,
0.0045067174,
0.018447628,
0.004128692,
0.05375189,
0.017145906,
-0.032424696,
-0.018579114,
0.0014907339,
0.005716398,
0.018000571,
0.02905863,
-0.011058058,
0.026678715,
-0.02237909,
-0.008954265,
-0.021222003,
-0.014555612,
0.030136822,
-0.0056407927,
0.0012852856,
0.008139046,
0.010190243,
0.0007400253,
0.0104137715,
0.013556311,
-0.02358877,
-0.03055758,
-0.01993343,
-0.0022056946,
-0.013161849,
0.0072186366,
0.03878867,
0.020078067,
0.019538969,
0.0014496443,
0.013293337,
0.029716063,
-0.0021152974,
0.003347988,
0.0034088008,
0.0017422029,
0.005529029,
-0.0069885347,
-0.002467025,
-0.016054563,
0.026981134,
0.0110186115,
0.005519167,
0.009545957,
0.016067712,
0.01640958,
0.023010226,
-0.006018818,
-0.015094709,
-0.010611001,
0.0047729784,
0.007665693,
0.004089246,
-0.005982659,
0.0067452835,
-0.02437769,
0.013885028,
-0.022944484,
0.01219542,
0.0028319014,
0.018053167,
-0.015489169,
0.0021777535,
-0.024048975,
-0.0037210824,
-0.008185066,
0.00056580506,
0.0038229849,
0.0026133044,
-0.010538684,
-0.019815093,
-0.015462873,
-0.0113210315,
-0.01750092,
0.007849774,
-0.015857333,
-0.02945309,
0.0015285364,
0.01230061,
0.04241771,
0.0056736646,
-0.019065617,
0.018197803,
0.02824341,
0.020866988,
-0.02247113,
0.0072580827,
-0.013556311,
-0.0093027055,
0.01863171,
-0.009361875,
-0.018184653,
0.012155974,
-0.000100823825,
-0.009486788,
-0.013648352,
-0.004710522,
0.011064632,
-0.01872375,
0.006025392,
0.05475119,
0.0123663535,
0.008664994,
-0.0103808995,
-0.021853141,
-0.025521629,
-0.0035961696,
-0.03421292,
0.0031408959,
-0.010657022,
-0.006035254,
0.00875046,
-0.02015696,
-0.032240614,
0.018184653,
-0.0013099393,
0.016383281,
-0.0101245,
0.023338944,
0.03613263,
-0.023338944,
0.008053579,
-0.008520358,
-0.0049997936,
-0.002187615,
-0.014831735,
0.041181732,
-0.0046250555,
-0.031030934,
0.02287874,
-0.012517563,
-0.011117226,
-0.011866703,
-0.008303405,
0.0058807563,
0.044679284,
0.0118929995,
-0.023720257,
-0.009098901,
-0.0027924553,
-0.015502319,
0.015462873,
-0.009624849,
-0.023049673,
0.004013641,
-0.0060648383,
0.019867687,
-0.022234453,
0.025692562,
-0.03910424,
-0.020367337,
0.022313345,
0.009184368,
-0.00521346,
-0.0019147795,
0.00814562,
-0.012622753,
-0.004598758,
-0.031556882,
-0.026981134,
0.000112688474,
-0.020380486,
0.016974973,
0.03905164,
0.014332084,
0.0035698724,
0.019999174,
0.03905164,
-0.00080700155,
0.03492295,
-0.0062916535,
0.02277355,
-0.024666963,
0.012944896,
-0.0048091374,
-0.0007704317,
0.03147799,
-0.031977642,
0.03928832,
0.026363146,
-0.0057722796,
-0.019183954,
0.010939719,
-0.029689766,
-0.02945309,
0.005890618,
-0.0050556753,
-0.0060714125,
-0.030215714,
0.0041549895,
0.0130369365,
0.015633805,
-0.0022648638,
-0.021024773,
0.035396304,
-0.019341739,
0.035790764,
0.010545258,
-0.0012770676,
-0.016356984,
-0.01964416,
-0.013142127,
-0.026481483,
-0.01109093,
-0.010571555,
0.017921679,
0.016882932,
-0.020459378,
-0.0025623532,
0.01331306,
-0.01508156,
-0.007613098,
-0.0014973084,
-0.017579813,
-0.01508156,
-0.011215842,
-0.0012861073,
-0.042864766,
0.0037868258,
-0.010571555,
-0.0008949335,
-0.0020511975,
-0.016659403,
-0.029794956,
0.002853268,
-0.008737312,
0.03350289,
-0.003048855,
0.016186051,
0.054277837,
-0.0051904498,
-0.019105062,
-0.020078067,
-0.0080996,
-0.0020199693,
0.03999835,
0.02824341,
0.0031918471,
0.008717589,
-0.0051510036,
0.021484977,
-0.006771581,
-0.010972591,
0.007054278,
0.014003366,
-0.013207871,
0.003714508,
0.007488185,
-0.00670255,
-0.0044935686,
-0.013490567,
0.015239344,
-0.019302294,
-0.011630026,
-0.03936721,
0.045152638,
-0.018395033,
0.010703042,
0.018381884,
-0.012635902,
-0.02499568,
-0.03145169,
-0.029742362,
-0.010262561,
-0.0093355775,
0.01801372,
-0.012399225,
0.0062916535,
0.027954139,
0.011768088,
-0.017264245,
-0.0013534944,
0.0039643333,
0.041865464,
0.008684717,
-0.01437153,
0.0046086195,
-0.012208569,
0.011143524,
-0.009098901,
-0.02845379,
-0.016790891,
-0.035264816,
-0.014713396,
0.015344534,
0.023207458,
-0.0035961696,
-0.0074355905,
-0.007205488,
0.0029716063,
-0.03492295,
-0.040340215,
-0.011840405,
-0.030689068,
-0.010512386,
0.0073764212,
0.019354887,
0.020288445,
-0.0025048275,
-0.0052989265,
-0.0065874993,
0.017080162,
0.0103808995,
0.014568761,
0.010564981,
-0.010933145,
-0.022865592,
0.009026583,
-0.019368036,
-0.0095722545,
0.007639395,
-0.03878867,
-0.015397129,
0.020025471,
-0.004763117,
0.0028565552,
-0.004296338,
0.0016074287,
-0.031635776,
0.0030225576,
0.015265642,
0.009131772,
-0.025561074,
0.0035337133,
-0.024890492,
-0.01750092,
0.011610303,
0.0024982532,
-0.023970082,
0.00080494705,
-0.0018260259,
-0.00012152276,
-0.018092612,
0.008993711,
-0.02298393,
0.007902369,
-0.025679413,
0.014923776,
0.0024259354,
-0.0003001602,
-0.019815093,
0.017869085,
0.0029732499,
-0.017080162,
-0.032556184,
0.020709204,
0.008678143,
0.020485677,
0.005838023,
-0.015186749,
0.0064264275,
-0.021445531,
-0.03108353,
0.0021580306,
-0.034765165,
0.043075144,
0.025653116,
-0.009631423,
-0.014437273,
0.0023108842,
-0.04512634,
-0.017224798,
-0.0115577085,
0.02763857,
-0.0023108842,
0.019723052,
-0.022300197,
0.025837198,
-0.0019788796,
0.008934543,
-0.015436575,
-0.014950073,
0.0130698085,
-0.0075802263,
0.010959442,
-0.016107159,
-0.02792784,
-0.02884825,
0.026468335,
-0.0011225704,
-0.005174014,
0.009026583,
-0.031215016,
0.032240614,
-0.028190814,
0.032293208,
0.027796354,
0.021300895,
0.028637871,
-0.025679413,
-0.016159754,
0.013950772,
-0.008217938,
0.009914121,
-0.0067978785,
-0.017685004,
0.0033529187,
-0.0031343217,
0.0101770945,
-0.008047005,
0.018934129,
0.000012769905,
-0.0047959886,
-0.009611701,
0.018763196,
0.002702058,
0.011649749,
-0.0026379582,
-0.01007848,
-0.018986724,
-0.04202325,
0.012077082,
0.0023684097,
-0.007501334,
-0.013181573,
-0.02398323,
-0.012109954,
-0.040024646,
-0.0077314363,
0.015489169,
-0.0009343796,
-0.014121705,
0.018776344,
0.0052594803,
-0.013345932,
-0.024154164,
0.018289844,
-0.024719559,
-0.021682208,
-0.018040018,
0.015094709,
-0.0103808995,
0.0022812996,
-0.040866163,
-0.024916789,
0.0036882106,
-0.0060944227,
-0.026244806,
-0.026376294,
0.0004659571,
0.16378021,
-0.04210214,
0.0032888188,
-0.0062029,
-0.006870196,
-0.010637299,
0.00021551542,
0.03168837,
-0.0130369365,
0.0064330017,
0.0009146565,
-0.007146319,
-0.02014381,
0.0055027315,
0.035264816,
-0.032372102,
-0.022944484,
-0.0064461506,
0.00084316044,
0.0064625866,
0.0031310343,
-0.024417138,
0.01952582,
-0.00062908314,
0.037210822,
-0.0127673885,
-0.016961824,
0.012011338,
0.022405386,
0.024929937,
-0.021406084,
0.002475243,
0.0078234775,
0.019407483,
-0.008178492,
-0.01426634,
0.013924474,
-0.009388172,
0.025876643,
0.010873975,
0.024627516,
-0.000027042153,
0.015186749,
-0.00325266,
-0.0018819078,
0.019854538,
-0.00855323,
-0.005861033,
-0.0009836872,
-0.007876072,
-0.015660103,
0.031740963,
0.03523852,
0.00318856,
0.009289557,
-0.0004881455,
-0.0055783363,
0.007836626,
0.01650162,
0.022865592,
-0.034896653,
0.011689195,
-0.037500095,
0.031030934,
-0.010749063,
0.0104466425,
-0.0036158927,
-0.018763196,
0.019828241,
-0.023260051,
0.0035435748,
-0.010505812,
-0.019670457,
-0.0016575581,
-0.0013543162,
-0.0062423456,
0.034659974,
0.016554214,
0.004408102,
-0.0019936718,
0.026008131,
0.006791304,
-0.038420506,
-0.017185353,
-0.011150098,
-0.049149845,
0.017132757,
-0.00035480948,
-0.017185353,
-0.024640666,
-0.014621356,
-0.008020707,
-0.0033825033,
-0.011347329,
0.010052182,
-0.0022089817,
0.011840405,
0.018855236,
0.0027809502,
-0.0155943595,
-0.013418249,
0.080101885,
0.019749349,
-0.0006364793,
-0.0032871752,
-0.0022303483,
-0.017474623,
0.0031277472,
0.013339357,
-0.01001931,
-0.0010896986,
0.0136089055,
0.0060122437,
-0.026126469,
0.00052266085,
0.018842088,
0.020249,
-0.01426634,
0.0025442736,
-0.0046973736,
-0.004861732,
-0.032740265,
0.0054139774,
-0.0057131103,
0.00045568467,
0.011012037,
-0.009618275,
0.015213047,
0.014240043,
0.007277806,
-0.0027053452,
-0.024114717,
-0.004523153,
0.023523025,
0.0022500714,
-0.0142137455,
0.013188147,
0.007810328,
-0.008849076,
0.029374197,
-0.015712697,
0.011505113,
0.02297078,
0.0066137966,
0.0051477165,
-0.005647367,
0.031399097,
-0.0021251587,
-0.013687798,
-0.020840691,
-0.01669885,
-0.009467064,
-0.013148701,
-0.009368449,
0.031662073,
-0.027954139,
-0.018487073,
-0.02398323,
0.009960141,
-0.01178781,
-0.0027299991,
0.01952582,
0.0071397447,
0.008257384,
-0.0022402098,
-0.0038196975,
-0.16346465,
0.02215556,
0.026297402,
0.009072604,
0.026862796,
0.0034679698,
0.0014143072,
0.017579813,
0.024048975,
0.004858445,
0.028690465,
-0.007021406,
-0.046283428,
0.0017339849,
0.012504415,
-0.009059455,
0.007665693,
0.049360223,
0.021577017,
0.00069647026,
0.007034555,
-0.021905735,
0.030215714,
0.0072515085,
-0.0039478973,
0.025442736,
0.008546656,
-0.010959442,
-0.025074573,
-0.0035008416,
0.008139046,
0.0009261616,
0.032161724,
-0.01903932,
0.0119258715,
-0.0005871717,
-0.009670869,
-0.026534079,
0.007915518,
0.020498825,
0.027296703,
0.020590866,
0.0118272565,
0.0036816362,
-0.017934827,
0.019815093,
-0.028059328,
0.009914121,
0.031136123,
0.0075276312,
0.023825446,
-0.011630026,
-0.0017586388,
0.019105062,
0.014095407,
0.016580513,
0.0013337714,
0.01923655,
0.005887331,
-0.0030422807,
0.014240043,
-0.00092205266,
0.022037223,
0.007922092,
0.009730038,
-0.021484977,
0.0121494,
0.030610176,
-0.039130535,
0.002587007,
-0.020840691,
-0.014621356,
0.007961539,
-0.028506383,
0.00024407275,
0.0129711935,
-0.010006161,
-0.011518262,
0.0053580957,
0.00407281,
-0.02247113,
-0.0057755667,
-0.03176726,
-0.0122282915,
-0.03392365,
0.007652544,
-0.00072564394,
0.030452391,
0.003504129,
0.004855158,
0.016462173,
-0.02428565,
-0.018750047,
-0.00056005246,
0.02479845,
0.038104936,
-0.029794956,
-0.018329289,
0.004749968,
0.0038196975,
0.026060725,
-0.010709617,
-0.026389442,
0.0182241,
0.02691539,
0.012287461,
-0.03145169,
-0.0072843805,
0.054488216,
-0.02298393,
-0.004523153,
0.016383281,
0.0075276312,
-0.010131074,
-0.012622753,
0.03452849,
-0.008770184,
-0.0009023296,
0.036290415,
-0.0068964935,
0.05706536,
-0.0071397447,
0.01640958,
0.03976167,
0.011807533,
-0.014805437,
-0.14190078,
-0.026783904,
0.0061042844,
0.037000444,
-0.020919584,
0.014055962,
-0.007948389,
0.035606682,
-0.026468335,
0.0242988,
-0.0046809376,
-0.019381186,
0.0062357713,
-0.024364542,
0.02853268,
0.007126596,
0.010229689,
-0.010131074,
-0.035974845,
0.02691539,
0.00068126706,
0.013595757,
-0.0051838756,
-0.005706536,
0.005252906,
0.020604014,
-0.032372102,
0.005726259,
0.021682208,
0.010190243,
0.022050371,
-0.017737597,
0.03513333,
-0.003924887,
-0.004536302,
-0.005381106,
-0.0046053324,
-0.030662771,
0.04160249,
-0.010229689,
-0.0005653941,
-0.0059497873,
0.007001683,
-0.024640666,
-0.0017619259,
-0.0051411423,
-0.02357562,
-0.011117226,
0.014305786,
-0.023102267,
-0.02763857,
-0.025626818,
-0.011728642,
-0.013779839,
0.019683605,
-0.013674649,
0.010939719,
0.007488185,
0.0022171997,
-0.0030784395,
0.0008784976,
-0.00683075,
0.0010264205,
-0.02368081,
0.026783904,
0.0036487645,
-0.019289143,
-0.012616179,
0.017487772,
-0.03592225,
0.0033759288,
-0.006002382,
-0.02003862,
-0.0015531903,
-0.04504745,
-0.010611001,
-0.026862796,
0.018986724,
-0.0092698345,
-0.031556882,
0.008664994,
-0.027217811,
0.01609401,
0.00422402,
0.023956934,
0.004930763,
0.034949247,
-0.03563298,
0.015568062,
-0.022260752,
-0.0075539285,
0.026902242,
0.010058756,
-0.0046283426,
-0.027507082,
-0.0066039353,
0.05120104,
-0.011169821,
0.019512672,
0.011419646,
-0.0038196975,
-0.0077445847,
-0.04646751,
-0.0057295463,
-0.011051483,
-0.0095722545,
0.009217239,
-0.010032459,
-0.00538768,
-0.014042812,
0.009828654,
0.027454488,
-0.004069523,
0.0145161655,
-0.009197516,
-0.0063508227,
-0.02955828,
-0.022642063,
0.015015816,
-0.010906847,
-0.011630026,
0.012912025,
0.014739694,
-0.005522454,
0.015173601,
-0.013595757,
-0.04809795,
0.00042075844,
-0.01239265,
0.0064428635,
0.0028006732,
-0.03392365,
-0.0006340139,
-0.0364482,
-0.0066269455,
0.010361176,
-0.019354887,
-0.0000759132,
0.006824176,
0.023141714,
0.030189417,
0.04917614,
0.020354189,
-0.04331182,
-0.003961046,
-0.008211364,
-0.02541644,
-0.000109195855,
-0.031819858,
0.009670869,
-0.0153576825,
0.0035238517,
0.042969953,
0.0028877833,
-0.00035419312,
-0.016817188,
-0.0021514562,
0.01872375,
0.02520606,
-0.013819285,
0.003068578,
-0.016422728,
0.035790764,
0.0052463314,
-0.00034720788,
0.0062522073,
-0.007126596,
-0.0010691538,
-0.038578287,
-0.0066466685,
-0.010348028,
0.0036849235,
0.010315156,
-0.0041878615,
-0.0024029252,
0.011985041,
0.016172903,
-0.0066302326,
-0.02691539,
0.024154164,
-0.01911821,
0.04068208,
0.013063234,
0.015857333,
-0.012780537,
0.021616464,
0.0485976,
0.0077248616,
-0.0059530744,
0.005670377,
-0.011597155,
0.018197803,
-0.00093766674,
0.029295305,
-0.014660802,
0.017698152,
-0.0073764212,
0.00011546203,
-0.012155974,
0.0010050539,
-0.00435222,
0.025350695,
-0.020104364,
0.017632408,
0.024022676,
-0.009473639,
-0.023141714,
0.0047565424,
-0.020972177,
-0.051989965,
-0.020406784,
-0.005404116,
-0.003093232,
-0.013477419,
-0.0045856093,
-0.004431112,
-0.030320905,
0.020170107,
0.0027069887,
-0.004033364,
-0.012326907,
0.024009528,
-0.013543162,
0.00040596613,
-0.0030669344,
-0.008434892,
-0.007336975,
0.01639643,
0.038183827,
-0.0139113255,
0.034896653,
0.0074224416,
0.01245182,
-0.0080996,
-0.011833831,
-0.01396392,
-0.0065874993,
0.009559105,
-0.015817888,
0.011570857,
-0.025876643,
0.08662364,
0.019946579,
-0.03815753,
-0.0039478973,
0.0021300896,
0.033765864,
0.0011546203,
-0.000056498324,
0.003938036,
0.0033989393,
0.012109954,
-0.003941323,
0.009664295,
-0.015725845,
0.0016279735,
0.018145207,
-0.0035304262,
-0.0027891682,
-0.0011587293,
-0.017987423,
0.0078432,
-0.01290545,
0.011248713,
0.015568062,
-0.051358826,
-0.0057821414,
0.020511974,
0.017172204,
0.009355301,
-0.02105107,
-0.008586102,
0.0013255534,
-0.048834275,
0.01346427,
-0.0050030807,
0.008829352,
-0.031925045,
-0.024890492,
0.023943784,
0.03886756,
-0.0028220399,
0.019854538,
-0.020709204,
-0.0068899193,
-0.027270406,
-0.022523725,
0.0026001555,
-0.023299498,
-0.015068411
] |
Simian immunodeficiency virus (SIV) naturally infects non-human primates in Africa. To date, 40 SIVs have been described both in natural hosts and in heterologous species. These viruses are highly diverse and the majority cluster in 6 relatively equidistant phylogenetic lineages. At least 8 SIVs are currently considered as recombinant viruses, based on different clustering patterns in different genomic regions. Only three types of genomes are known, based on the number of accessory genes: vpr-containing genomes, vpr-vpx containing genomes and vpr-vpu-containing genomes. vpx resulted | [
-0.014762603,
-0.019861925,
-0.012487316,
-0.016194696,
-0.008492177,
0.031639885,
-0.00091680716,
0.00029549465,
-0.026112275,
0.012654616,
0.0050457856,
-0.0051026675,
0.006541453,
-0.013645035,
-0.004440157,
0.007220693,
0.027410528,
-0.006397574,
0.016756825,
0.003172019,
-0.020812193,
0.009870734,
0.008465409,
-0.048289638,
0.0050558234,
0.016890667,
-0.0069864723,
-0.020316983,
-0.011911801,
-0.000083075196,
-0.001621979,
0.0012129291,
-0.0036772666,
-0.004724568,
-0.00863271,
-0.004302971,
0.009174764,
0.000991256,
-0.0024827407,
-0.015993936,
0.024104668,
0.031559583,
-0.009944347,
0.020879112,
0.006006091,
0.020223293,
-0.0038445673,
-0.0063206158,
-0.017426029,
0.01445477,
0.021494778,
0.012928989,
-0.012594388,
0.021615235,
-0.019728085,
-0.0062168897,
-0.0061901216,
-0.006026167,
0.017519716,
-0.030247945,
-0.0016696597,
-0.0019774928,
-0.028829236,
0.023274856,
-0.021561699,
0.01197203,
0.009315296,
-0.0056079156,
0.008224497,
-0.006872708,
0.0432037,
0.011296135,
-0.020263446,
0.002288672,
0.020263446,
-0.00582206,
-0.027838817,
0.008646094,
-0.008057196,
0.01227317,
0.016556066,
-0.025456456,
-0.012212942,
0.008117424,
0.021053106,
0.0004730424,
0.026272884,
0.02173569,
0.013624959,
0.0060362048,
-0.00016175874,
0.002636657,
0.0038144533,
0.02632642,
-0.02722315,
0.02702239,
0.0026048701,
0.009382216,
-0.0033443386,
-0.04422089,
-0.01025218,
0.004302971,
-0.0034028937,
-0.018603824,
-0.025228927,
0.017452797,
-0.0038880655,
-0.013484427,
0.012433779,
0.00012516175,
-0.02619258,
0.029953497,
-0.004149054,
-0.042213283,
0.037555635,
-0.0047914884,
0.03787685,
-0.020919265,
-0.011028454,
-0.008398489,
0.014160321,
-0.007240769,
0.027892353,
-0.014066633,
0.038358677,
0.008987387,
-0.0041323244,
-0.011931878,
-0.015605798,
-0.016315153,
0.03969708,
0.0067622894,
0.002906011,
0.0015843365,
-0.02275288,
0.008746474,
-0.02583121,
-0.0124605475,
0.018175535,
-0.007923355,
0.017051276,
0.019165954,
-0.00401856,
0.015819943,
0.0030599276,
0.01809523,
0.0060094367,
-0.023167783,
-0.0018854776,
-0.0064444183,
0.01051986,
-0.0039683697,
0.027116077,
-0.005172934,
0.018817969,
0.0073879934,
-0.013812336,
0.023328392,
-0.024613261,
-0.00013770928,
-0.011168987,
0.009536133,
-0.008284724,
0.014816139,
0.006681985,
0.026339803,
0.01164412,
-0.004276203,
-0.017626788,
-0.007327765,
-0.008806703,
0.017385876,
-0.021508163,
0.025376152,
0.0057183336,
0.02140109,
0.017921237,
0.016703289,
-0.01994223,
-0.0070533925,
-0.008057196,
0.03450407,
0.023502385,
0.017666942,
-0.027397143,
-0.0037776472,
0.007849744,
-0.014213857,
0.02209706,
0.0027152884,
-0.00916138,
-0.014856291,
0.022083677,
-0.023248088,
-0.6475737,
-0.028052961,
0.0074616056,
0.0046978,
0.03230909,
0.02322132,
0.022471813,
0.0039851,
-0.035681866,
0.039750617,
-0.023007175,
0.0051060137,
0.03996476,
-0.027089309,
-0.01104853,
-0.0413567,
0.008124116,
-0.017613405,
0.012955757,
-0.01339743,
-0.01733234,
0.0056380294,
-0.0038044152,
0.037903618,
0.0061600073,
-0.005681528,
0.0125007,
-0.022685958,
0.0041958983,
-0.00080848,
-0.014294161,
0.028668627,
-0.004901907,
-0.021936452,
0.048503783,
-0.014869675,
0.000018350782,
0.030542394,
0.02344885,
0.03870666,
-0.0010606857,
0.0076222145,
-0.00082060933,
-0.003131867,
-0.02077204,
0.009000771,
0.012299938,
0.0070065483,
0.018590441,
-0.021120025,
0.016622985,
0.008873623,
-0.01567272,
-0.004406697,
0.013370662,
-0.014160321,
0.019928845,
-0.02020991,
0.02738376,
0.0027604597,
0.0040988643,
-0.0007624724,
0.006487916,
-0.011282751,
-0.0053603104,
0.022070292,
-0.024760487,
0.0126278475,
0.008224497,
-0.024171587,
0.02153493,
0.023248088,
-0.0025781018,
-0.018550288,
-0.016341921,
0.023502385,
0.0061800834,
-0.017988158,
-0.01935333,
-0.0052097403,
-0.012741612,
-0.013879256,
-0.026687788,
0.0041657845,
-0.002273615,
-0.015525494,
-0.012581004,
0.012306631,
-0.015860096,
0.017640173,
0.019072266,
0.009971115,
-0.0061934674,
-0.03297829,
-0.008612634,
0.010084879,
0.0018988616,
-0.00456396,
-0.03664552,
-0.016810361,
-0.0064711864,
-0.004671032,
0.008880314,
0.0010288985,
0.029525205,
-0.0042193206,
-0.036270764,
-0.004339777,
0.047566902,
-0.018684128,
-0.01832276,
-0.0004893542,
0.023301624,
0.0130159855,
0.0076422906,
-0.029926728,
0.023917291,
0.00022585578,
0.0041791685,
-0.018991962,
0.017760629,
0.002307075,
-0.0028206878,
-0.004286241,
0.02302056,
0.0060027447,
0.010734005,
-0.048717927,
-0.01984854,
-0.007481682,
0.0014463135,
0.000984564,
0.007943432,
0.0028323987,
0.013517886,
0.011269367,
0.018684128,
0.011021762,
-0.024573108,
-0.014240625,
-0.014133553,
-0.013062829,
-0.0006344874,
0.019393483,
-0.0032673804,
-0.016395457,
-0.014093401,
-0.0013626632,
0.004908599,
-0.023167783,
0.028829236,
-0.018858122,
0.00747499,
0.0062536956,
0.007896587,
-0.009569593,
-0.0008373394,
-0.049761884,
0.0010473016,
0.011992105,
0.01276838,
0.013457659,
0.020022534,
0.009576285,
0.015164125,
-0.011081991,
-0.0038546054,
0.003446392,
-0.0038111072,
-0.050672,
-0.0018018272,
-0.018215688,
-0.015913632,
0.028427714,
0.0042059366,
0.009830582,
0.007742671,
-0.002867532,
-0.020571278,
0.0128353005,
-0.0012790129,
-0.015592414,
-0.019554092,
0.0071470807,
0.024787255,
0.0053067743,
0.03677936,
0.0057049496,
0.026835013,
0.028615091,
0.016930819,
0.00233217,
-0.0032974945,
0.021093257,
-0.00088334706,
-0.0039884457,
0.0016253252,
0.032496464,
0.011088682,
0.028133266,
0.013959561,
0.0076222145,
0.0006717118,
-0.017439412,
0.031639885,
-0.032496464,
0.0039047955,
-0.028989844,
0.011590584,
0.01270146,
0.022404894,
0.0012313323,
0.0008975676,
-0.013069522,
-0.0026851743,
0.012975832,
-0.010245487,
0.00231544,
-0.01551211,
-0.002573083,
-0.024974631,
0.0025781018,
0.0029628933,
-0.011864957,
-0.025108472,
0.017720478,
-0.009134612,
0.010513169,
0.00391818,
-0.025121855,
-0.024010979,
-0.0154184215,
0.011925185,
-0.0022418278,
0.024064515,
0.016622985,
-0.0018904966,
-0.021120025,
0.009562901,
0.0073612253,
-0.017158348,
0.0076690586,
0.008873623,
0.0011920166,
0.026072122,
0.007849744,
0.0184566,
0.009415677,
-0.02067835,
0.032897986,
-0.014909827,
0.002300383,
-0.01025218,
0.016475761,
0.015860096,
-0.014039865,
0.009736894,
-0.000075023854,
0.033620723,
0.0154318055,
-0.0018620554,
-0.018135382,
0.014601994,
0.006062973,
0.018603824,
-0.0018486714,
-0.015003516,
-0.0103191,
0.015083821,
0.014080017,
-0.007515142,
-0.014842907,
0.012681384,
-0.0050725536,
0.026968854,
0.002280307,
-0.010834386,
-0.017238652,
-0.0014329294,
-0.00021435387,
-0.0206382,
-0.021320786,
0.0009435753,
0.008124116,
-0.008779935,
0.005959247,
-0.01699774,
-0.017412644,
0.0058789426,
0.0053168125,
-0.006959704,
0.015873479,
0.00093521026,
0.010352559,
0.0018838046,
-0.022311205,
0.024439268,
0.0038177993,
0.0053268503,
-0.0023304971,
-0.0010707238,
0.002020991,
0.00083022914,
-0.013129749,
0.040767804,
-0.0043899673,
-0.008552406,
-0.006899476,
-0.017626788,
0.004406697,
0.0070199324,
-0.0076690586,
-0.017372493,
-0.020330366,
-0.016154544,
0.022404894,
-0.027303455,
0.017626788,
0.02232459,
-0.01667652,
0.0011092029,
-0.03747533,
-0.00747499,
-0.01908565,
0.012179482,
-0.0022568847,
-0.009870734,
0.017292188,
0.012895528,
0.0098640425,
-0.024947863,
-0.030087337,
0.030917147,
-0.023877138,
-0.0033376466,
-0.007722595,
0.017506333,
0.013102981,
0.046924468,
0.015605798,
-0.010345868,
-0.028561555,
-0.02007607,
0.0041791685,
0.013618267,
-0.021882916,
0.0021648696,
0.02765144,
0.0019022076,
-0.016275,
0.02209706,
0.023261473,
-0.002303729,
-0.03407578,
-0.0075954464,
0.006136585,
-0.005986015,
0.023328392,
0.008264649,
-0.031398974,
-0.012012182,
0.018309375,
0.0068794,
0.013584807,
0.022351358,
0.018282607,
-0.0021063143,
0.0074616056,
0.010332484,
0.005233162,
-0.01445477,
-0.004885177,
-0.0036203845,
-0.02679486,
0.031291902,
0.0016738423,
0.000041406893,
-0.011148911,
0.010125031,
0.006113163,
-0.004433465,
-0.0019022076,
-0.029792886,
-0.028133266,
-0.018925041,
-0.01852352,
0.004908599,
-0.018215688,
-0.027678208,
-0.015083821,
-0.0006796586,
-0.0010949823,
-0.013578115,
-0.032523233,
0.021575082,
-0.028186802,
0.010934765,
-0.00087079953,
0.006106471,
-0.0009260087,
0.007936739,
-0.00863271,
0.016743442,
0.016248232,
-0.016448993,
-0.014601994,
-0.0011485185,
-0.01101507,
0.0039416016,
0.023114247,
0.0019457057,
-0.0061700456,
-0.010533244,
-0.008278033,
0.005166242,
-0.012828608,
0.0037642631,
0.019781621,
0.012654616,
0.016756825,
0.041142557,
0.023703147,
-0.0065581826,
-0.01980839,
0.012132638,
-0.030756539,
0.004011868,
-0.023248088,
0.006718791,
-0.0022050217,
-0.00070768147,
0.001706466,
-0.048289638,
-0.036431376,
0.031827264,
-0.026219347,
0.01432093,
0.008492177,
0.031987872,
0.01733234,
0.02245843,
-0.00048182567,
0.010171875,
-0.035039432,
-0.0062202355,
0.0060228207,
0.010814309,
0.017707093,
-0.025148623,
-0.0024793947,
0.020397287,
-0.005564417,
-0.012393627,
0.004333085,
0.008900391,
0.045425452,
0.022284437,
-0.000991256,
-0.023796834,
0.011590584,
0.0051762797,
0.0059559005,
0.0037843392,
-0.009582977,
0.0058588665,
-0.001154374,
0.01339743,
-0.012440471,
-0.026339803,
-0.025095087,
-0.0044635795,
0.02434558,
-0.0052933902,
-0.010392712,
-0.017613405,
0.0041189403,
0.004905253,
-0.0013082905,
-0.02931106,
-0.022846567,
-0.016034087,
0.011369747,
0.029953497,
0.02666102,
0.00750845,
-0.025630448,
0.024947863,
0.0240779,
0.01915257,
-0.0027035773,
-0.015592414,
0.0068292096,
-0.026072122,
0.010379327,
0.0025948319,
0.0021916376,
-0.0059425165,
0.0010238795,
0.022672575,
0.014013097,
-0.020009149,
-0.038064227,
0.0075820624,
-0.032496464,
0.0055945315,
0.0098506585,
0.0008967311,
0.023770066,
-0.037823316,
0.008846855,
0.016863897,
-0.004891869,
0.004995595,
0.010111647,
0.025630448,
0.011664196,
-0.0053402344,
-0.0010749062,
0.012052334,
-0.027731745,
0.009803814,
-0.017626788,
0.009054307,
0.013852488,
-0.025898129,
0.015860096,
0.034878824,
-0.0091145355,
0.003121829,
0.03520004,
0.003453084,
-0.022685958,
0.008304801,
-0.006066319,
-0.006414304,
-0.016569449,
-0.014146937,
-0.029150452,
-0.0115772,
-0.00522647,
-0.0048216027,
0.011128834,
-0.007274229,
-0.020785425,
0.014695683,
0.014722451,
0.04058043,
-0.009402293,
0.03308536,
0.030435322,
-0.010653701,
-0.032737378,
0.0070199324,
0.0035735404,
0.008291417,
0.021320786,
0.023917291,
0.0139461765,
-0.037154112,
0.032683842,
0.0068024416,
-0.02513524,
-0.057979688,
0.025724137,
-0.00027981022,
-0.004229359,
-0.021360938,
-0.006939628,
-0.004570652,
0.026259499,
-0.0059425165,
0.019366715,
0.0005387079,
-0.0055610714,
-0.024814023,
0.009643205,
0.008994079,
0.0022635767,
0.0021565044,
-0.016796978,
-0.01998238,
-0.018536905,
-0.0034012208,
-0.0050892835,
-0.005768524,
0.03370103,
0.018817969,
-0.020745272,
-0.0017666941,
0.00003573436,
0.004962135,
0.016863897,
-0.004236051,
0.036431376,
-0.011938569,
-0.0027955926,
-0.018536905,
0.018336143,
0.0061666993,
0.035842475,
0.010707237,
-0.0016579487,
-0.013009293,
-0.006420996,
0.028748931,
0.041758224,
0.011389824,
0.00013310852,
-0.0122664785,
0.003128521,
-0.048610855,
-0.045987584,
0.00401856,
-0.02239151,
0.025898129,
-0.010533244,
0.0067087533,
0.009770354,
0.0244125,
0.0024977976,
0.004888523,
0.01746618,
-0.01137644,
0.005681528,
0.01964778,
0.01098161,
-0.050216943,
-0.012112562,
-0.013671803,
-0.007983584,
0.00691286,
-0.0050892835,
-0.032523233,
-0.0024526266,
0.00060981064,
0.0050324015,
-0.0070734685,
-0.019995766,
0.028133266,
-0.011731117,
0.0019055536,
-0.0039416016,
-0.0045137694,
0.014829523,
-0.008947235,
-0.015632566,
0.0016320172,
-0.016341921,
0.0075753704,
-0.0085457135,
0.006337346,
0.010078187,
-0.022806415,
-0.03308536,
-0.013283666,
-0.019313179,
0.015324733,
-0.008960619,
-0.025804441,
-0.012085794,
-0.013430891,
-0.0044769635,
-0.007160465,
-0.020022534,
-0.016863897,
0.039322328,
-0.0021966565,
-0.019259643,
0.002613235,
-0.006732175,
0.019393483,
-0.031532813,
-0.025777673,
-0.0023639572,
-0.034718215,
0.043096628,
0.020879112,
0.007756055,
-0.016489144,
-0.018831354,
-0.050190173,
0.0038512594,
0.00024300409,
0.011938569,
0.0046476102,
0.02371653,
0.004339777,
0.0076690586,
0.005423885,
0.020022534,
-0.0014396214,
-0.018403064,
0.010044727,
0.00916138,
0.0024425886,
0.006611719,
-0.009910886,
0.004995595,
0.025483225,
-0.014026481,
0.006163353,
0.00856579,
-0.009047615,
0.023315009,
-0.0010933093,
0.029712582,
0.012614463,
0.0038345293,
0.012212942,
-0.012320015,
-0.035253577,
0.020129606,
-0.011931878,
-0.013879256,
-0.015164125,
-0.026821628,
0.011818113,
0.013276974,
-0.0113362875,
-0.03228232,
0.008371721,
-0.011818113,
0.011128834,
-0.0074281455,
0.0091011515,
0.012668,
-0.008472102,
-0.019259643,
-0.0046543023,
0.011061914,
-0.00041971533,
0.023435466,
0.02807973,
0.006404266,
-0.0013844123,
0.0056413757,
0.01045294,
-0.010412788,
0.019687932,
0.006668601,
-0.013370662,
-0.024974631,
0.020183142,
0.021923067,
-0.010365943,
-0.00029988628,
0.0030749845,
-0.009067691,
-0.01432093,
0.0053000823,
-0.0073813014,
0.003223882,
0.020852344,
-0.021213714,
-0.011242599,
-0.019754853,
-0.009047615,
-0.000041119347,
-0.030676235,
0.008713014,
0.17666942,
0.0044368114,
0.02569737,
0.017359108,
-0.017024508,
-0.007909971,
0.018951809,
0.0013760473,
-0.003463122,
0.006066319,
0.016783593,
0.012400319,
0.0017901162,
0.0048383325,
0.0083516445,
-0.008010352,
-0.021160178,
-0.019313179,
-0.007923355,
0.014039865,
0.019861925,
-0.0037642631,
0.008050504,
-0.021521546,
0.00992427,
0.012065718,
-0.042614803,
-0.0007055902,
-0.0056112614,
0.0107942335,
-0.02027683,
-0.00016970553,
0.0070533925,
0.0067020613,
-0.01256762,
0.009803814,
-0.012353475,
0.012079102,
0.009870734,
0.018630592,
-0.007950123,
0.026286267,
0.0067221373,
-0.025523376,
-0.027142845,
0.017720478,
0.005213086,
-0.014187089,
-0.017680325,
0.0053235046,
-0.02259227,
0.0035400803,
-0.0073478413,
0.006243658,
-0.010727313,
-0.012085794,
0.032790914,
0.00019385955,
-0.009375525,
0.02517539,
-0.0071403887,
0.009582977,
-0.014601994,
0.021949835,
-0.0005730045,
0.027437296,
-0.015097205,
-0.0146689145,
0.026152426,
-0.0222309,
-0.01445477,
-0.017586637,
-0.014963364,
-0.01984854,
-0.0036705746,
-0.016556066,
0.028802468,
0.010613549,
0.030970683,
-0.0006064646,
0.0076222145,
-0.019433634,
-0.024225123,
0.020852344,
-0.0038378753,
-0.033486884,
0.03857282,
-0.007200617,
-0.027490832,
0.021307401,
0.00020797554,
-0.006635141,
-0.010138415,
-0.024666797,
-0.009549517,
0.018925041,
-0.0024425886,
-0.013772184,
0.009134612,
-0.03774301,
-0.0055744555,
0.06997179,
0.0016780248,
0.0038044152,
0.00009682521,
0.0073478413,
0.014936596,
0.0018955156,
0.004604112,
-0.013919408,
-0.009342064,
-0.016756825,
0.004620842,
-0.012299938,
0.027116077,
0.020598046,
-0.008331569,
-0.046870932,
0.023462234,
0.017024508,
-0.015873479,
-0.02947167,
-0.027169613,
0.0059090564,
-0.0068057873,
-0.035066202,
-0.023596074,
0.041758224,
-0.012942373,
-0.0003398293,
0.0071002366,
-0.016663138,
-0.0075753704,
0.011249291,
0.01432093,
0.004868447,
0.016957587,
-0.011242599,
0.019313179,
-0.011523664,
0.0026851743,
-0.0056380294,
0.025081703,
-0.015324733,
0.011108759,
-0.012808532,
0.04183853,
0.021427859,
-0.00003063692,
0.0093956,
-0.017680325,
-0.018376296,
0.0044736173,
-0.0029779503,
0.016783593,
-0.027410528,
-0.023167783,
-0.020169757,
-0.0035701944,
0.0021381015,
-0.033593956,
0.012346783,
0.017974773,
-0.018925041,
-0.024118051,
-0.0021565044,
-0.16906728,
0.0032707264,
0.019527324,
-0.009984499,
0.028668627,
0.0067422134,
0.030943915,
0.0032991674,
-0.004962135,
0.0065447986,
0.031050988,
0.013102981,
-0.028427714,
-0.019112417,
0.008191036,
-0.0056647975,
-0.027102694,
0.024439268,
0.037528865,
-0.0061533153,
0.008298108,
-0.019955613,
-0.0059826686,
-0.032068174,
0.004379929,
0.0038546054,
-0.007889896,
-0.021949835,
-0.00069806166,
-0.026072122,
0.014347698,
-0.0044602333,
0.036725823,
-0.024519572,
0.013444275,
-0.004048674,
-0.0033393195,
0.009663281,
-0.0068425937,
0.0022050217,
0.024452653,
0.00010226248,
0.016034087,
-0.025857978,
-0.0013124731,
-0.0014705721,
0.0055476874,
-0.022779647,
0.0017006104,
-0.005119398,
0.007294305,
0.008331569,
0.006765635,
0.010647009,
0.01760002,
-0.0077159028,
0.010580089,
0.010372636,
0.0130293695,
0.0078229755,
-0.027812049,
-0.031773727,
0.03870666,
-0.026513796,
0.0052164323,
-0.032496464,
-0.014936596,
0.006377498,
-0.032068174,
0.03172019,
-0.013056138,
0.015137357,
-0.01733234,
-0.03335304,
0.0076623666,
0.023743298,
-0.016034087,
0.012962448,
-0.019754853,
-0.026607484,
-0.0076222145,
0.02447942,
-0.01739926,
-0.0135446545,
-0.012159406,
0.0041858605,
0.018469984,
-0.004891869,
0.011570508,
-0.010325791,
-0.0041858605,
-0.029525205,
-0.007200617,
-0.03201464,
0.013852488,
0.03172019,
0.012955757,
-0.0070333164,
0.005494151,
-0.0069797803,
0.009964422,
-0.013584807,
-0.026754709,
0.0042661647,
0.016368689,
-0.0300338,
-0.0049788654,
0.015699487,
0.05519581,
-0.0017014468,
-0.012286554,
0.010580089,
-0.00410221,
0.021454627,
-0.014173705,
0.019915462,
-0.026701173,
-0.0037174188,
0.030542394,
-0.021789227,
0.048209336,
-0.0070400084,
-0.0075753704,
0.019607628,
-0.012219634,
-0.00999119,
-0.13384046,
-0.0131966695,
-0.0027922466,
0.0275176,
-0.029123684,
0.030355018,
0.00859925,
0.006839248,
-0.03230909,
0.0013643362,
-0.0091145355,
-0.02973935,
0.002569737,
0.0047981804,
0.01104853,
0.011603968,
-0.006059627,
-0.009168072,
-0.016328536,
0.0102254115,
0.022685958,
-0.006019475,
0.014508306,
-0.002889281,
0.005694912,
0.0040988643,
-0.012795148,
0.0025463148,
0.006906168,
0.01382572,
0.015338117,
-0.020049302,
-0.0067823655,
-0.009636513,
-0.018055078,
0.03161312,
-0.0038177993,
-0.013350586,
0.0375021,
-0.01445477,
0.004115594,
0.00575514,
0.0062336195,
0.01339743,
-0.0035333883,
-0.018724281,
-0.0016244886,
0.01683713,
-0.0047714124,
-0.037234418,
-0.02067835,
-0.0037910312,
-0.051608883,
-0.0053101205,
0.009449136,
-0.03185403,
0.012728228,
0.025456456,
0.0076556746,
-0.015726255,
0.0025279117,
0.010821002,
-0.012159406,
-0.017546484,
0.010432865,
-0.01600732,
-0.004908599,
-0.005701604,
0.025054935,
-0.032469697,
0.0049454053,
-0.011938569,
-0.021454627,
-0.0017984812,
-0.01438785,
0.00045840358,
-0.0070868526,
-0.016970972,
0.00466434,
-0.0047948346,
-0.0065247226,
-0.004292933,
0.022632422,
-0.021989988,
0.023662994,
0.028936308,
0.011175679,
-0.011122143,
-0.018938426,
-0.020718504,
-0.011456744,
0.0044970396,
-0.021762459,
-0.025911514,
0.0044435035,
0.0033393195,
-0.012969141,
-0.030810075,
0.017024508,
0.030622698,
-0.040205676,
-0.000101582824,
-0.05474075,
0.006481224,
0.013156517,
-0.025443071,
-0.0041122483,
-0.0002373577,
0.00631727,
-0.018068463,
-0.0053335424,
-0.00053117936,
-0.029953497,
0.013410814,
-0.04547899,
0.03680613,
-0.020986184,
-0.00005881661,
0.02546984,
0.0005010652,
-0.001422055,
0.02821357,
0.009502673,
-0.00985735,
0.01333051,
0.024265276,
0.0071136206,
0.010740697,
-0.015231045,
0.03324597,
-0.017760629,
0.009449136,
0.0011175679,
-0.013551347,
-0.014829523,
-0.000493955,
0.00750845,
-0.0146822985,
0.031934336,
0.021588467,
0.021454627,
0.057926152,
-0.030007033,
-0.032175247,
-0.003141905,
-0.00200928,
-0.0013860853,
0.014213857,
0.0039215256,
0.014775987,
0.008813394,
-0.020116221,
0.022726111,
0.013718648,
-0.030007033,
-0.018724281,
-0.023676379,
0.0062168897,
0.0115772,
0.00041762408,
-0.010131723,
-0.01703789,
0.020598046,
0.004323047,
0.030863611,
0.013865872,
-0.016288385,
-0.022311205,
-0.031131292,
0.014749219,
0.002623273,
-0.0057183336,
-0.023328392,
0.018577056,
0.00286084,
0.010091571,
-0.015592414,
0.004433465,
0.0024091282,
0.021120025,
-0.00078924047,
-0.020651583,
-0.0010439556,
-0.011684272,
0.00091680716,
0.010861154,
0.037823316,
0.008298108,
0.008552406,
0.042480964,
-0.012192866,
-0.0013367316,
-0.00056171167,
0.018068463,
-0.002598178,
0.00800366,
0.0060362048,
0.016890667,
-0.0133773545,
0.010305716,
0.01928641,
0.015833328,
-0.0074013774,
0.01326359,
0.01600732,
-0.036458142,
-0.02014299,
0.007863128,
-0.02421174,
-0.030943915,
-0.030703003,
-0.004008522,
0.019554092,
-0.00079467776,
0.009388909,
-0.002034375,
-0.0159404,
0.024586493,
-0.0020628162,
0.010660393,
-0.031398974,
0.012949064,
0.012132638,
0.029926728,
-0.010446249,
-0.011055223,
-0.0053569647,
0.02864186,
0.015311349,
-0.02864186,
-0.00076958264,
-0.011523664,
-0.0023840333,
-0.010693853,
-0.010720621,
-0.0113362875,
-0.034825288,
-0.0009778719,
0.010513169,
0.018282607,
-0.0055276114,
0.061941367,
-0.007167157,
-0.0025262388,
0.0092952205,
-0.0287757,
0.025670601,
0.006866016,
0.012614463,
-0.011931878,
-0.016194696,
0.010580089,
-0.030863611,
0.030247945,
-0.015003516,
-0.029659046,
0.013276974,
-0.020290215,
-0.00022648316,
-0.013343894,
-0.005186318,
0.03450407,
-0.008505561,
0.050216943,
0.008237881,
-0.009422368,
0.00052323256,
0.028748931,
-0.0126412315,
-0.019005345,
-0.050029565,
0.009060999,
0.015552262,
-0.038144533,
-0.024318812,
-0.010546628,
-0.00694632,
-0.008391797,
-0.004256127,
0.029070148,
-0.00403529,
-0.008177652,
-0.008090656,
-0.006263734,
-0.014575226,
0.030060569,
-0.012708152,
-0.036110155,
-0.008291417,
0.006474532
] |
OBJECTIVE Chronic physical comorbidity is common in dementia. However, there is an absence of evidence to support good practice guidelines for attention to these problems. We aimed to study the extent of this comorbidity and its impact on cognitive function and disability in population-based studies in low and middle income countries, where chronic diseases and impairments are likely to be both common and undertreated. METHODS A multicentre cross-sectional survey of all over 65 year old residents (n = 15 022) in 11 catchment areas in China, India, Cuba, Dominican Republic, Venezuela, Mexico and Peru. We estimated the prevalence of pain | [
0.008039604,
0.015272602,
0.037685644,
-0.039748438,
-0.016978374,
0.026895648,
-0.010902391,
0.0030578263,
-0.021685774,
-0.0037057549,
-0.0060197855,
0.024581617,
0.023973359,
0.037077382,
-0.016502345,
0.020297354,
0.047946718,
-0.0070544877,
0.015021365,
-0.0060726777,
-0.033295598,
0.028323736,
-0.0026892342,
-0.004892522,
-0.008449518,
0.01757341,
0.021421313,
-0.03951042,
-0.013937077,
-0.028720427,
0.009837937,
-0.012323867,
-0.020760162,
-0.028958442,
0.0004179718,
-0.011669327,
-0.007067711,
-0.02376179,
0.016687468,
-0.03755341,
0.015470948,
-0.0016842837,
-0.014452775,
0.00603962,
-0.0027570024,
0.027451016,
-0.0032842706,
-0.006796639,
-0.014505667,
0.010347023,
0.017375065,
0.05323593,
-0.024303934,
0.0039041003,
0.020019671,
-0.024303934,
-0.00046321936,
0.025560122,
-0.0030991482,
-0.018300677,
-0.008899101,
0.0055073933,
-0.009639591,
0.009857771,
-0.045355003,
-0.004446245,
0.00850241,
0.0006375981,
0.032978244,
0.0009619756,
0.05328882,
0.024674179,
-0.0051040906,
-0.009527195,
0.042974856,
0.006122264,
-0.013831292,
-0.0031520403,
0.006036314,
0.0027305563,
0.0070082075,
-0.03279312,
-0.0020561817,
0.024912193,
0.015206488,
-0.0010173471,
0.0059801163,
0.025123762,
0.0063999477,
-0.00029772485,
-0.01451889,
-0.0002671466,
0.014717235,
0.0038115392,
0.005348717,
0.014333767,
0.005001612,
0.012284197,
-0.012747004,
-0.020588262,
-0.024317157,
0.0045355,
-0.04556657,
-0.011781722,
-0.015418056,
-0.020760162,
-0.0027983242,
0.0032991467,
0.012614773,
-0.002690887,
-0.0023289067,
0.037288953,
-0.0007380105,
-0.028588196,
-0.008621417,
-0.015418056,
-0.012277585,
-0.0103338,
0.010049505,
-0.025956813,
0.016370114,
-0.01151065,
0.024806408,
-0.012442874,
-0.009487526,
-0.00204957,
-0.026353505,
0.007616467,
-0.010142066,
-0.0093420725,
-0.032819565,
0.016594905,
0.0040363306,
0.0032859235,
-0.020945285,
0.0018363487,
-0.018935382,
0.0010842887,
-0.04474674,
-0.024277488,
-0.003497492,
0.017057711,
-0.025150208,
-0.029196456,
0.0051602884,
0.057969775,
0.032608,
0.0026611353,
0.0030396446,
-0.0040264134,
0.0055933427,
-0.008112331,
-0.014558559,
0.020482477,
-0.0072065527,
0.007431344,
0.012396593,
0.025586568,
-0.008958604,
-0.023404768,
-0.014598228,
-0.022955185,
-0.016290776,
0.014413105,
-0.0033206341,
0.007828035,
0.001263626,
-0.022651054,
0.011629657,
0.0013305676,
0.00028367538,
0.04858142,
-0.015470948,
0.01800977,
0.0072396104,
-0.009203231,
0.005315659,
0.0068296962,
-0.030201407,
-0.03382452,
-0.024978308,
0.009361907,
0.019675873,
0.015008142,
-0.0057222676,
0.0068363077,
0.040303804,
0.00086362934,
-0.0065982933,
-0.020165125,
0.0046809535,
0.033295598,
-0.00976521,
-0.020112233,
-0.645284,
-0.0017421346,
-0.0063503613,
-0.025401445,
0.0013421378,
0.010624707,
0.011801557,
-0.0016710607,
-0.029196456,
0.033163365,
0.016674245,
0.013632947,
-0.002952042,
-0.013725508,
-0.013090802,
-0.0053751627,
-0.0116098225,
-0.00279006,
0.012826341,
0.014373437,
0.004115669,
0.002211552,
-0.006697466,
0.024251042,
-0.0027123746,
-0.0051999576,
0.0112461895,
-0.019913888,
0.007874316,
0.04993017,
-0.007570186,
0.014928804,
0.022439485,
0.028376628,
0.033956748,
-0.01757341,
0.0033305513,
0.018975051,
0.020548593,
0.014135422,
-0.014161868,
0.0025619625,
0.027160108,
0.0006020612,
-0.007861093,
-0.002773531,
0.0025801442,
0.0068693655,
-0.0020627931,
-0.015589955,
-0.0027156803,
0.007418121,
-0.022611385,
-0.01761308,
0.007993323,
-0.027398124,
0.0054842527,
-0.02136842,
0.012026348,
0.0015049464,
0.008985051,
0.017123828,
-0.018869268,
-0.012330478,
-0.032052632,
0.02742457,
-0.020310579,
0.01063793,
0.025467562,
-0.0072396104,
-0.002294196,
0.026459288,
0.0017074241,
-0.00012789152,
0.055060707,
-0.00928918,
0.028693981,
0.016713914,
-0.041573215,
-0.004006579,
0.0022512213,
0.0045057484,
-0.0026446064,
-0.0060230913,
0.014875912,
0.010604872,
-0.014413105,
0.008879267,
-0.009309015,
-0.013672615,
0.014664344,
0.010657764,
-0.007636301,
-0.023867574,
-0.004399964,
0.032766674,
-0.029566702,
0.0077619203,
0.04503765,
0.0068958113,
-0.029936945,
-0.004264428,
-0.0023421296,
-0.00008109438,
0.012588327,
0.013242867,
-0.032766674,
0.024475833,
0.050194632,
-0.007180107,
0.0020247768,
-0.0031603049,
0.0060230913,
-0.00019090754,
0.02795349,
-0.026776642,
0.017546965,
0.00082685275,
-0.0059106955,
-0.009513972,
-0.0021933706,
0.007656136,
0.016171768,
-0.014836242,
0.02093206,
0.000051549167,
-0.01194701,
-0.0070743226,
-0.025665905,
-0.0014123851,
0.00837018,
-0.0034016252,
0.019860994,
0.0061420985,
0.023272537,
0.0052561555,
0.0064991205,
-0.024449388,
0.005828052,
-0.033798072,
-0.008872655,
0.0015694087,
0.023127085,
-0.01871059,
-0.0028627866,
-0.0047867377,
0.0004285089,
-0.014056084,
-0.023404768,
-0.0017702335,
0.011768499,
-0.03160305,
-0.015563509,
0.0001546475,
-0.021130405,
-0.009837937,
0.004485914,
-0.005394997,
-0.011907341,
-0.014135422,
0.015946977,
-0.005973505,
-0.021593213,
0.0076891934,
-0.0050511984,
-0.027583245,
-0.016290776,
0.02795349,
-0.023470882,
-0.02567913,
-0.0058115227,
-0.013699062,
-0.00053264026,
0.014426328,
-0.0024016332,
0.0012066017,
0.0038743485,
-0.016581682,
0.0037784816,
-0.009785044,
0.011418088,
0.013765177,
-0.013712285,
-0.0073916754,
0.03631045,
-0.021778334,
0.025758468,
-0.00593053,
0.0011570153,
0.0066941604,
0.012350312,
0.036733586,
-0.023986582,
0.014942027,
-0.012429651,
0.0053883856,
-0.000046332265,
0.0025619625,
0.0065685413,
0.014069307,
0.039272405,
-0.008654475,
0.005097479,
-0.015576732,
0.029672485,
-0.00033305513,
-0.0007433824,
-0.011411477,
0.009937109,
-0.010181735,
-0.006558624,
-0.009044554,
0.0077619203,
-0.008958604,
-0.025282439,
0.03771209,
0.005709044,
0.0054445835,
-0.022056019,
-0.0066379625,
0.008026381,
-0.0017140356,
0.014942027,
0.012356924,
0.007947043,
0.017229611,
0.012198248,
0.017652748,
0.017454403,
-0.0072528333,
-0.018419685,
0.0066908547,
0.0059007783,
0.025890699,
-0.006753664,
0.011927175,
0.0010570162,
-0.02368245,
0.031761725,
0.023179976,
0.012522212,
0.04474674,
0.0064032534,
-0.0055007813,
-0.005837969,
-0.015325495,
0.02106429,
0.02516343,
0.011933787,
0.03305758,
-0.0057916883,
-0.009269346,
-0.021897342,
-0.016343668,
-0.006614822,
0.012594938,
0.001489244,
-0.005348717,
0.036045987,
0.03197329,
0.03596665,
-0.000022688348,
0.0067305234,
0.009599921,
0.0017454403,
-0.005328882,
-0.0031536932,
-0.0031569991,
0.004138809,
-0.0049850834,
-0.03252866,
-0.017665971,
-0.009309015,
-0.043107085,
0.0035173267,
0.020733716,
-0.017057711,
-0.010320577,
0.031682387,
0.017639525,
-0.02228081,
-0.030941896,
0.004697482,
0.0055702026,
-0.0009388353,
-0.015576732,
-0.012661054,
0.0114643695,
0.005699127,
-0.0035834417,
-0.019199843,
0.031206356,
-0.0034743517,
-0.011180074,
0.0010338759,
0.022532048,
0.038214564,
0.0014057737,
-0.00399005,
0.0043272376,
0.00078718364,
-0.009745375,
-0.017771756,
-0.026049374,
-0.008747036,
0.020019671,
-0.032819565,
-0.0071536605,
-0.0109552825,
0.0021966763,
0.008138777,
-0.021051068,
-0.0013545344,
-0.0080329925,
0.011041232,
0.015629625,
-0.005742102,
0.010968505,
0.019715542,
-0.014783351,
-0.001427261,
-0.025348553,
0.0045057484,
-0.016899036,
0.055272277,
-0.008951993,
-0.016224662,
-0.00067561434,
0.017282503,
-0.009335461,
-0.0125552695,
-0.030095622,
0.030598097,
0.029249348,
-0.007616467,
-0.026446065,
0.01827423,
0.011398254,
0.01643623,
0.0230213,
0.00070577936,
-0.013804846,
0.003224767,
-0.00134627,
-0.0015751937,
0.0012487501,
0.022836177,
0.04046248,
0.025784913,
-0.023946911,
-0.0054842527,
0.025824582,
0.017533742,
0.0049255798,
-0.013414767,
0.015034588,
-0.00667102,
0.036601353,
-0.017996548,
0.022267587,
0.022862623,
0.012145355,
0.017586634,
-0.0006107388,
0.03057165,
-0.0032925352,
0.018856045,
0.013884184,
0.02734523,
0.00009762317,
0.005401609,
0.019993225,
0.000309295,
0.0024165092,
0.036574908,
-0.0008297453,
0.019133728,
-0.031814616,
0.029751824,
-0.01151065,
-0.0019090753,
-0.00858836,
0.0009851159,
-0.01674036,
-0.003718978,
-0.008661087,
-0.0006677631,
-0.0072197756,
-0.021804782,
-0.027067548,
-0.029646039,
-0.009732152,
0.0005954497,
0.0025255992,
-0.011781722,
-0.0018561832,
-0.018512245,
0.0037123663,
-0.009216454,
-0.00050288846,
0.040647604,
-0.00806605,
0.0043074028,
0.0032082382,
0.00014793267,
0.00036859204,
-0.006013174,
-0.019821325,
0.0083238995,
0.016661022,
-0.006261106,
-0.021130405,
-0.011742053,
0.026340282,
0.001748746,
-0.008376791,
0.017097382,
0.006961927,
0.0048462413,
-0.00582144,
0.02040314,
0.020165125,
-0.02433038,
-0.02362956,
0.023179976,
-0.023563445,
-0.0035966649,
-0.029884053,
-0.004095834,
-0.013857738,
-0.031074127,
0.00066611025,
0.00377187,
-0.042102136,
0.019874219,
-0.031841062,
0.001271064,
-0.0060759834,
0.00013966828,
0.0029503892,
-0.013857738,
0.025573345,
0.029011333,
-0.009917274,
-0.0087602595,
0.004631367,
0.025255993,
0.0108825555,
-0.032819565,
0.00064214354,
-0.0041586435,
-0.024859302,
-0.055695415,
-0.017150274,
0.0055140047,
0.025004754,
0.0028231174,
-0.031576604,
-0.015589955,
0.01670069,
-0.003785093,
0.0014776739,
-0.016343668,
0.0019090753,
-0.0016859367,
-0.00005914208,
-0.010796607,
-0.013408155,
0.04974505,
-0.034459222,
-0.01586764,
-0.0022727088,
-0.018075885,
0.02489897,
0.0017851094,
0.013381709,
-0.010459418,
0.003649557,
-0.02232048,
-0.020641154,
-0.013335428,
0.006330527,
0.022941962,
0.008185057,
0.030227853,
0.010915614,
-0.00601648,
0.019384965,
0.0035768303,
0.0035900534,
0.0036198052,
0.0035503842,
-0.014717235,
0.01006934,
0.008991662,
0.008522244,
-0.0063635847,
-0.020456031,
0.019913888,
0.0031189828,
-0.00998339,
-0.03509393,
-0.02729234,
-0.02577169,
-0.02315353,
-0.01225114,
-0.0027570024,
0.003841291,
-0.04072694,
0.010922225,
0.014479221,
0.025216322,
0.013685838,
-0.015973423,
0.009011497,
0.0035735245,
0.031497262,
-0.0011661062,
-0.00473054,
-0.03382452,
-0.010056117,
-0.013897407,
-0.0021983292,
0.011266024,
-0.015603178,
0.01918662,
0.00311733,
0.0047239284,
0.00033574106,
0.013937077,
-0.031206356,
0.0051073963,
-0.020429585,
-0.024409719,
-0.0065685413,
0.0024561782,
-0.0148230195,
-0.017097382,
-0.0024578313,
0.016766805,
-0.020826276,
0.028667534,
-0.0149684725,
-0.014770128,
-0.015047811,
-0.008244561,
0.022743616,
-0.029751824,
0.018512245,
0.009176784,
-0.016885813,
-0.031708833,
0.01120652,
0.017216388,
0.010062728,
0.03125925,
0.026882425,
-0.025626237,
-0.011999902,
0.0037553413,
0.013170141,
-0.005067727,
-0.028984888,
0.015299048,
0.026181605,
-0.0139502995,
0.0023206421,
-0.0013900714,
-0.0123370895,
0.002363617,
-0.022915516,
-0.021632882,
0.001468583,
-0.030280745,
-0.0017503989,
0.006710689,
-0.032158416,
0.017533742,
0.0022578328,
0.010796607,
-0.010604872,
-0.00046652512,
0.006340444,
0.023060968,
0.006548707,
0.010730491,
-0.024700625,
0.0058247456,
-0.0017008126,
0.00967926,
-0.00183139,
-0.0013107331,
-0.026882425,
0.0373154,
-0.007570186,
-0.020852722,
0.028350182,
-0.014981695,
0.0034941863,
-0.00021032886,
-0.0084693525,
-0.015285825,
-0.009606533,
-0.005765242,
0.012257751,
0.011960233,
-0.013672615,
0.009771821,
-0.013897407,
-0.011543707,
-0.009229677,
-0.007735474,
-0.0048561585,
-0.0033470802,
-0.0044197985,
0.007854481,
0.009844548,
0.021289082,
0.0030842724,
-0.0018941994,
0.019913888,
0.005044587,
-0.02406592,
0.013831292,
0.017150274,
0.0066776313,
-0.007682582,
0.017044488,
-0.028138613,
-0.03723606,
0.00020774624,
-0.011219743,
-0.0342741,
-0.014637897,
0.002352047,
0.017599856,
-0.0054611126,
-0.0030512149,
0.01565607,
0.008733813,
0.002211552,
-0.017361842,
-0.02429071,
0.015365164,
-0.019821325,
0.015682517,
0.023523776,
-0.008813151,
0.033507165,
-0.0063338326,
0.0042677335,
0.015047811,
-0.014280875,
-0.020151902,
-0.036204662,
0.025322108,
-0.028508859,
-0.0069553154,
-0.02123619,
-0.0159602,
-0.0014388312,
0.023656005,
0.0069487034,
0.0031569991,
-0.0055834255,
0.0013429642,
0.001993372,
0.0068958113,
0.010472642,
-0.020337025,
-0.0074247327,
-0.010849498,
-0.03366584,
0.0033586503,
-0.029751824,
0.014135422,
0.00867431,
0.027027879,
-0.028059276,
-0.025494007,
-0.033771627,
-0.013672615,
0.008780094,
0.0124098165,
0.014373437,
0.008052827,
0.013513939,
0.025745245,
0.020879168,
0.01586764,
-0.025427891,
-0.021831227,
0.0017454403,
-0.018128777,
0.017216388,
-0.002938819,
-0.015166818,
-0.017361842,
0.026181605,
0.007365229,
-0.004442939,
0.019239513,
0.017057711,
-0.01569574,
-0.007669359,
-0.00028140267,
-0.01700482,
-0.02694854,
0.0038115392,
-0.02254527,
-0.005206569,
-0.01364617,
-0.009685871,
0.019874219,
-0.0039305463,
0.023563445,
-0.01408253,
0.006981761,
-0.02009901,
-0.028588196,
0.00028718775,
-0.032211307,
0.0044925255,
-0.0013214768,
0.0055933427,
0.021778334,
0.017150274,
-0.0062148254,
-0.019133728,
0.0028892327,
0.007120603,
-0.017454403,
0.0051073963,
-0.019887442,
-0.0070214304,
-0.0125552695,
-0.020958507,
-0.016991597,
-0.019080836,
-0.058022667,
-0.012198248,
-0.018327123,
0.013388321,
0.0060330085,
-0.0104461955,
0.00806605,
-0.0053222706,
-0.016780028,
-0.011841225,
-0.02332543,
-0.00031528668,
-0.038664147,
0.0023437825,
0.0044297157,
-0.013394932,
0.0019652732,
-0.0047371513,
-0.00049049186,
-0.0041090576,
0.019980002,
0.18427618,
-0.007913985,
-0.008211503,
0.001566103,
-0.009044554,
0.022188248,
0.035781525,
-0.018022994,
-0.01787754,
0.038479026,
0.011358585,
-0.016594905,
-0.013500717,
0.01172883,
-0.011252801,
-0.014254429,
-0.028482413,
-0.019702319,
-0.004446245,
-0.015880862,
0.0031470817,
-0.005193346,
0.014016415,
-0.001216519,
0.035358388,
0.009335461,
0.003198321,
-0.011351974,
0.04376824,
0.007894151,
-0.0012537087,
0.0006752011,
-0.010194958,
0.009368518,
-0.01949075,
0.00052065693,
-0.0010305701,
-0.029619593,
0.014360214,
0.005504087,
0.0061850734,
0.0069487034,
-0.002515682,
0.009487526,
0.02829729,
0.028720427,
0.0155502865,
-0.017798202,
-0.0012735433,
0.00045950038,
-0.032634445,
-0.013104025,
-0.0002824357,
0.037923656,
-0.010776771,
0.0026974985,
0.010142066,
0.009540418,
-0.018102331,
0.012072628,
0.0050511984,
0.0012842871,
0.0021272553,
0.020945285,
-0.00989744,
0.0102280155,
-0.023880797,
-0.009441245,
-0.0137784,
-0.017361842,
0.017031265,
-0.034247655,
-0.0069487034,
-0.0016429618,
-0.00058759854,
0.0022793203,
0.044931866,
0.006042926,
0.008290841,
0.020032894,
-0.014928804,
-0.016687468,
-0.001216519,
0.010327188,
-0.01129247,
-0.037103828,
0.020297354,
0.007332172,
-0.023563445,
0.0040826113,
-0.004128892,
-0.0031123713,
-0.01129247,
-0.012462708,
0.019437857,
0.012264363,
-0.010485865,
-0.006796639,
0.0066908547,
-0.0007499939,
-0.029222902,
0.093777746,
-0.009309015,
-0.00087024085,
-0.008039604,
-0.002925596,
-0.004076,
-0.005794994,
0.0073189484,
0.011213131,
-0.01098834,
-0.023140308,
0.007094157,
-0.020588262,
-0.0007570186,
0.028350182,
0.017242834,
-0.006680937,
0.024092365,
-0.008304064,
-0.0020842806,
-0.049507033,
-0.0084693525,
0.009685871,
-0.013401544,
-0.013216421,
0.0027867542,
-0.014227983,
0.0025090703,
-0.03858481,
0.0022297339,
-0.016370114,
0.011755276,
-0.008310676,
-0.019583311,
0.025375,
0.0111007355,
-0.005828052,
-0.0074577904,
0.02140809,
0.0019751906,
-0.048634313,
0.020879168,
-0.005933836,
0.012654442,
-0.00505781,
-0.011113958,
0.007067711,
-0.008667698,
-0.012085852,
-0.03654846,
-0.0116098225,
0.0070875455,
0.011794945,
0.02232048,
-0.03509393,
-0.006109041,
-0.020006448,
-0.007160272,
-0.0036330281,
-0.020601485,
0.009699094,
0.020879168,
0.020654377,
-0.006902423,
0.024846079,
-0.16692756,
0.02232048,
-0.0014206496,
-0.025546899,
0.018472577,
-0.008403237,
0.00268097,
-0.022069242,
-0.002733862,
-0.019001497,
0.01207924,
0.013348651,
-0.033903856,
-0.0063106925,
0.0032280728,
0.0100098355,
-0.037447628,
0.018353568,
0.01726928,
0.020945285,
0.0186577,
-0.026141936,
-0.009738764,
-0.015180041,
-0.0030793138,
0.005709044,
-0.0074048983,
0.014452775,
-0.0061586276,
-0.018419685,
0.0038181506,
-0.018961828,
0.052283872,
-0.008773482,
-0.01451889,
0.007147049,
-0.030122068,
-0.017996548,
0.00082726596,
0.0030743552,
0.017388288,
0.036601353,
0.006287552,
0.0058313576,
0.0050478927,
0.034485668,
0.029064225,
-0.031470817,
0.016727136,
-0.0018760178,
0.017639525,
-0.0019189926,
0.04429716,
-0.0038115392,
-0.0004706573,
0.011689161,
0.012727169,
0.008912324,
-0.002745432,
0.0043305433,
-0.00801977,
-0.02550723,
-0.008654475,
0.017956879,
0.018684145,
-0.027636139,
0.009388353,
0.0023289067,
-0.007649524,
0.025454339,
-0.027054325,
-0.006961927,
-0.0057619363,
-0.007067711,
0.025123762,
0.032052632,
-0.009117281,
0.002419815,
-0.011550319,
-0.00538508,
-0.016224662,
-0.0062809405,
-0.034512114,
-0.009143727,
-0.0132230325,
-0.0023669228,
0.025996482,
-0.0028462578,
0.009804878,
-0.026221273,
0.015801525,
-0.042498827,
0.048158284,
0.0036198052,
-0.0029718766,
0.053341713,
0.0018908937,
-0.0023983275,
0.010399915,
-0.0132825365,
0.010267685,
0.0032760063,
-0.0042743455,
-0.0045156656,
0.0068693655,
0.018644476,
-0.012978407,
-0.019543642,
0.0072925026,
-0.00872059,
-0.0006710689,
0.018300677,
0.014003191,
0.022796508,
0.013302371,
0.0032578246,
-0.0033983195,
0.0039834385,
-0.007616467,
-0.00032355107,
0.062254038,
-0.009150338,
-0.014003191,
-0.003999967,
-0.0039933557,
0.00046735155,
-0.12355602,
0.0055073933,
0.001148751,
0.019027945,
0.014029638,
0.010181735,
-0.015285825,
0.015894085,
-0.008337122,
0.029857608,
-0.0005078471,
-0.018935382,
-0.0063338326,
-0.010532145,
0.02909067,
-0.03266089,
-0.017970102,
-0.02524277,
-0.013388321,
0.03366584,
0.019133728,
-0.009408188,
0.03422121,
-0.036389787,
-0.019213066,
-0.0061685448,
-0.0013140389,
0.017454403,
0.0059966454,
0.0053090476,
-0.015603178,
-0.0049123564,
0.002309072,
0.016304,
-0.005001612,
0.0024264264,
0.0074577904,
-0.013791623,
0.037341844,
-0.019451082,
0.0092825685,
0.010360246,
0.004456162,
0.008350345,
0.014452775,
-0.013606501,
-0.0029338603,
0.007147049,
0.015153595,
0.012350312,
-0.005236321,
-0.016766805,
-0.021619659,
-0.017811425,
0.010611484,
-0.026829533,
-0.004604921,
0.018168448,
-0.0012016431,
-0.0077751433,
0.0008900754,
-0.0077949776,
-0.015775077,
0.0463864,
0.03453856,
-0.020337025,
-0.01770564,
-0.030254299,
-0.014413105,
-0.011351974,
-0.013580054,
0.011305693,
-0.008244561,
0.002461137,
-0.027398124,
0.030412976,
0.0042743455,
-0.013897407,
-0.0033669146,
0.004575169,
-0.030412976,
-0.0053123534,
0.016647799,
-0.018432908,
0.014346991,
0.008753648,
-0.008899101,
-0.00019245711,
0.008475964,
-0.029672485,
0.009018108,
0.025903922,
0.019570088,
-0.009322238,
0.02013868,
0.0025041117,
-0.014558559,
-0.013057745,
0.017599856,
0.028270844,
-0.011563542,
-0.007947043,
-0.03771209,
0.0299105,
0.011894118,
-0.0008652822,
0.00889249,
0.00981149,
0.021910565,
-0.015074257,
-0.011563542,
0.012125521,
-0.029513808,
0.012515601,
0.0015214751,
0.009798267,
-0.03334849,
-0.021778334,
0.034512114,
0.014836242,
0.035437725,
0.033612948,
0.009170173,
0.023219645,
0.028984888,
0.058710266,
-0.012363535,
-0.0057454077,
-0.016793251,
0.025110539,
-0.01800977,
0.00732556,
0.0014908969,
-0.014637897,
0.010538757,
0.013520551,
0.013447824,
-0.011385031,
0.015206488,
0.017110605,
0.008958604,
0.04921613,
-0.011689161,
-0.015682517,
0.0012470973,
-0.034379885,
-0.0106643755,
0.0020346942,
-0.03422121,
0.023642782,
0.0074577904,
-0.012998241,
0.03165594,
-0.001675193,
0.0003611541,
-0.01569574,
-0.016158545,
-0.0006293337,
0.0002047504,
0.017494071,
0.0043503777,
-0.009844548,
0.014307321,
0.003497492,
0.010651153,
-0.00017458535,
0.005728879,
-0.021527097,
-0.008581748,
-0.0068032504,
-0.0066412683,
-0.01822134,
-0.021037845,
-0.005454501,
0.0031801392,
-0.0038710427,
0.007120603,
-0.0077288626,
-0.0065387897,
0.0077553084,
0.00060578017,
0.01871059,
0.018869268,
0.021196522,
-0.0183139,
0.025613014,
0.019913888,
0.008099107,
-0.020707268,
0.025427891,
-0.010604872,
-0.011001563,
0.012066017,
0.008218115,
-0.0038908774,
0.015589955,
0.00012789152,
0.012978407,
-0.0040793056,
0.0005103264,
0.0228494,
0.005219792,
-0.0012016431,
0.012561881,
-0.032369982,
-0.047576472,
-0.0063867248,
-0.009335461,
-0.032740228,
-0.016674245,
-0.01151065,
0.031629495,
0.02402625,
0.02734523,
0.0019189926,
-0.0055602854,
-0.0032727006,
0.0050611156,
-0.007636301,
0.008462741,
-0.0039007945,
0.016885813,
0.0017454403,
0.018776705,
0.010512311,
0.015775077,
0.015312272,
-0.0067073833,
-0.0032429488,
-0.015708962,
0.02288907,
0.00023512205,
0.018022994,
-0.012270974,
-0.012317255,
-0.0007929687,
-0.012918903,
-0.05759953,
0.012508988,
0.011927175,
-0.0044528563,
0.065110214,
-0.013467658,
-0.012151967,
0.0051735113,
-0.0091238925,
-0.021170076,
-0.011986679,
0.0016256066,
-0.0059007783,
-0.013791623,
-0.0008293321,
-0.0049421084,
0.019834548,
-0.024713848,
-0.008628028,
0.018908937,
-0.0037222838,
0.021818005,
0.007041265,
-0.016290776,
0.015761854,
-0.013831292,
0.006823085,
-0.0025751856,
-0.013804846,
-0.00377187,
0.02882621,
-0.024846079,
-0.027715476,
-0.027636139,
0.019120505,
-0.013408155,
-0.021170076,
-0.022294033,
0.02655185,
-0.02332543,
-0.0010041241,
-0.019768434,
0.005864415,
0.006862754,
-0.0060958182,
0.024013028,
-0.026141936,
-0.008945381,
-0.014690789,
-0.026591519,
0.007180107,
-0.015788302,
-0.022161802
] |
BACKGROUND Recent studies show that COPD patients exhibit low-grade systemic inflammation, and that plasma fibrinogen and high neutrophil counts are related to faster declines in lung function. We examined correlations between serum biomarkers and the decline of lung function in COPD patients. METHOD Baseline levels of 9 serum biomarkers (TIMP-1, alpha1-antitrypsin, MMP-9, TNF-alpha, TGF-beta, IL-6, IL-8, neutrophil elastase and CRP), fibrinogen and white blood cell counts (WCC) were measured in 96 COPD patients. | [
-0.021565486,
-0.005006506,
0.00455641,
-0.041330583,
-0.004129145,
0.017638559,
-0.03264177,
0.017899483,
-0.03624254,
-0.017234124,
-0.0043281005,
0.013776862,
0.0127527295,
0.028206037,
-0.019191064,
-0.0074037584,
0.033450637,
0.012674452,
-0.022778789,
-0.010847974,
-0.017390678,
0.012113462,
-0.0012369496,
-0.012478758,
-0.025648968,
0.01009129,
0.024566127,
-0.039582387,
-0.010234799,
-0.011187177,
0.018734444,
-0.006112178,
-0.020613108,
0.01693406,
0.009575963,
-0.0020645724,
0.004781458,
0.00878014,
0.014311759,
-0.017090615,
0.006901477,
-0.0013698584,
0.00064823654,
0.016346976,
-0.0052054618,
-0.01317021,
0.03551195,
-0.0019667253,
-0.026927503,
0.0069536623,
0.015733803,
-0.012641836,
-0.015838172,
-0.018982323,
0.0058414675,
-0.018617028,
0.0069667087,
0.036268633,
-0.011552473,
-0.023300638,
-0.019047555,
0.002488576,
-0.012726637,
0.009308514,
-0.008036503,
0.0020482645,
-0.007932132,
0.03668611,
0.0009752087,
0.025688106,
0.032589585,
0.031389326,
-0.004647734,
-0.0037377565,
0.022713557,
0.013620307,
-0.01720803,
0.0068101534,
-0.015159766,
0.017260216,
0.030345626,
-0.022217799,
-0.008232197,
0.019843377,
0.0064970427,
-0.0058251596,
0.00012312418,
0.0051956773,
-0.0005083968,
-0.0019341096,
0.0033528914,
0.009915166,
0.01619042,
0.015368506,
-0.0034279076,
-0.0046151183,
-0.006193717,
0.012159124,
0.014898841,
-0.032693952,
0.005919745,
-0.010163045,
-0.011572042,
-0.0031066432,
-0.015851218,
-0.0012328726,
-0.0063633183,
-0.025166256,
0.016086051,
-0.008245243,
0.003551847,
0.02914537,
0.009497685,
-0.035720687,
0.01836915,
-0.00559685,
0.0039791125,
0.012707068,
0.0040312978,
-0.01930848,
0.021291513,
0.020613108,
0.048532125,
-0.025179302,
0.004879305,
0.0062719947,
-0.013307196,
-0.0122700175,
-0.015003211,
0.0010070091,
0.0011358409,
0.011245885,
0.025949033,
0.008649677,
-0.028780073,
0.0078016696,
-0.014011694,
-0.021982966,
-0.036007706,
-0.007879947,
-0.0038192957,
0.031650253,
-0.0013837201,
-0.028832259,
-0.015825126,
0.0064872582,
0.037938554,
-0.004047605,
0.029849866,
-0.012667929,
-0.013385474,
0.014911887,
-0.002904426,
0.00060828234,
-0.007482036,
-0.018799676,
0.00967381,
0.033920303,
-0.022452632,
-0.008701863,
-0.010300031,
-0.0016911228,
0.019752054,
0.000317799,
0.020469598,
0.015785987,
0.0036399094,
-0.011435056,
0.0034050767,
0.017964715,
0.0043248385,
0.0395302,
-0.014416129,
0.0293802,
0.011793829,
0.0014889056,
-0.0060926084,
0.00016766496,
-0.021474162,
-0.060221586,
-0.01776902,
0.042843953,
0.036842667,
-0.028884443,
-0.014885794,
0.007227634,
0.056307703,
-0.0072993883,
0.005257647,
-0.03378984,
-0.0057436205,
0.014350898,
0.011500288,
-0.033659376,
-0.6416678,
-0.029588941,
0.01427262,
0.00247553,
0.019412851,
0.0075994525,
0.011056715,
-0.017012337,
-0.022400446,
0.042087268,
0.024318248,
0.006386149,
-0.016907966,
-0.002248851,
0.014637915,
-0.03131105,
-0.03759935,
-0.013881232,
0.00790604,
-0.0035029235,
-0.018460473,
0.008173488,
0.019543312,
0.009947781,
-0.0015565831,
0.023796398,
0.015942542,
-0.0058642984,
0.003197967,
0.05030642,
-0.012328725,
0.01934762,
0.012863623,
0.02109582,
0.052211173,
-0.02105668,
-0.012387434,
0.020887079,
0.024970561,
0.02721452,
0.006894954,
-0.002692424,
0.023939906,
-0.02084794,
-0.024226924,
0.04620989,
-0.014533546,
0.01664704,
0.009497685,
0.0056066345,
-0.002866918,
0.025140163,
0.001591645,
0.017886437,
0.0078212395,
0.010939298,
0.0015174444,
-0.037729815,
-0.01406388,
-0.0041226214,
0.0074037584,
0.0021689425,
-0.009432454,
-0.009517254,
-0.013698584,
0.010893635,
-0.01493798,
-0.0032909217,
0.013998648,
-0.0061154393,
0.021761179,
0.04644472,
0.0059393146,
0.0047325348,
0.03819948,
0.008799709,
0.015994728,
0.0106392335,
-0.019034509,
-0.0018754014,
0.012550512,
0.018290872,
-0.008943219,
0.018056039,
0.024318248,
0.01273316,
-0.027866835,
0.0067253523,
-0.008408321,
0.011219793,
0.0053000473,
-0.0026353467,
-0.022896204,
-0.01296147,
-0.02742326,
0.021735087,
-0.00692757,
0.000121493395,
0.010737081,
-0.014207388,
-0.022139521,
-0.0120678,
0.011702505,
-0.0021982966,
0.043391895,
-0.016764458,
-0.022087336,
0.007990841,
0.028806165,
-0.02049569,
0.014990165,
-0.018473519,
-0.013222395,
-0.03551195,
0.017364586,
-0.015120627,
0.019386757,
-0.00137312,
-0.003636648,
-0.027057964,
-0.000010198769,
0.008460507,
0.021082774,
0.009589009,
0.008375705,
0.028101666,
-0.00846703,
-0.021695947,
-0.0049217055,
-0.029067092,
-0.0025081455,
-0.0014407975,
0.031963363,
-0.0049217055,
0.014729239,
-0.021630717,
0.021904688,
-0.000640898,
-0.0030658736,
-0.03480745,
-0.026496975,
-0.0028603948,
0.012687498,
-0.00499346,
-0.010430493,
-0.0052054618,
-0.012694022,
0.020978402,
0.012550512,
0.02452699,
-0.011624227,
-0.013581168,
0.009719471,
0.027579816,
0.00724068,
-0.007442897,
0.01406388,
-0.017899483,
0.010391355,
-0.013026701,
-0.004125883,
-0.0041748066,
0.006894954,
-0.01185906,
-0.0012434727,
-0.013789908,
-0.010065198,
0.01756028,
0.011506811,
-0.024918377,
-0.0104109235,
-0.012439619,
-0.013202826,
0.0021510038,
0.0024706374,
0.0057958057,
-0.020456553,
-0.01260922,
0.0013356119,
-0.012791868,
0.015981682,
-0.014207388,
0.0020694647,
0.004677088,
0.026079495,
0.01762551,
0.016346976,
0.023000576,
-0.008858418,
0.038069017,
-0.021134958,
-0.014037787,
-0.018577889,
0.01934762,
0.012720114,
-0.01360726,
-0.0036855715,
-0.02434434,
-0.022648325,
-0.0027315628,
-0.007044986,
-0.028466962,
0.008604015,
-0.026536115,
0.0074559436,
-0.003930189,
0.00037059563,
-0.011950384,
0.01658181,
0.009282421,
-0.0015631063,
0.015485923,
-0.0047618886,
-0.00034470693,
-0.024083415,
-0.0013910586,
0.009210667,
-0.012250448,
0.00802998,
-0.025022747,
-0.0016421993,
-0.00028681412,
0.017221076,
0.0031947056,
-0.023874676,
-0.0068166764,
0.0095303,
0.028101666,
0.014233481,
-0.012361341,
-0.015981682,
-0.0065198736,
0.018525705,
-0.008453983,
-0.009191098,
0.01262879,
0.006829723,
-0.011552473,
0.036868762,
0.009504208,
-0.012217833,
0.017312402,
0.009960827,
-0.002043372,
0.0011423641,
-0.02234826,
0.031571973,
0.021108866,
0.0068753846,
0.01196343,
0.013463751,
0.0036464327,
-0.0055414033,
0.001225534,
-0.0050521684,
-0.021708993,
0.016829688,
-0.00844746,
0.03337236,
0.025179302,
0.062152434,
-0.007762531,
0.0023695289,
-0.028727887,
0.035172746,
-0.0026532852,
0.0027919018,
-0.010795789,
-0.023796398,
0.0046183798,
-0.018760538,
0.009367222,
0.017925575,
-0.03911272,
0.022543956,
-0.004377024,
0.027605908,
0.008643154,
0.014637915,
0.019360665,
-0.006007808,
-0.025727246,
0.036581744,
0.026614392,
-0.020456553,
-0.023444148,
-0.023600703,
0.004902136,
-0.015799034,
0.028023388,
-0.007410282,
0.011591611,
0.007671207,
0.0037834186,
0.013437659,
0.008649677,
0.012256972,
-0.006480735,
0.014442221,
-0.00703194,
-0.012224356,
-0.0018835553,
-0.004262869,
-0.01619042,
0.023887722,
0.0134507045,
-0.018473519,
0.00069145235,
-0.011382871,
-0.011154561,
0.019256296,
-0.020195628,
0.009621625,
0.0065361816,
0.009641194,
0.011689458,
0.011330686,
-0.022570048,
0.038069017,
-0.0010657172,
-0.0057207895,
-0.021043634,
0.0026842703,
0.0039497586,
0.0021020803,
0.027188428,
0.017325448,
0.008206104,
0.004377024,
-0.0010347323,
0.0016348608,
-0.030528273,
0.02217866,
0.00033410682,
0.0054207253,
-0.014429175,
0.03872133,
0.0045922874,
0.0024347603,
0.009073681,
0.0034800926,
-0.026144726,
0.00016593226,
0.0056392504,
-0.020208674,
0.008088687,
0.012661406,
0.031989455,
0.023391964,
0.0078408085,
0.0125048505,
0.0046053333,
0.0056751277,
-0.014898841,
-0.027736371,
0.011617704,
-0.013000608,
0.012583128,
-0.0095303,
-0.01966073,
0.020756617,
-0.0063926727,
0.025309766,
-0.00062377483,
-0.0024738992,
0.0070710788,
0.008877987,
0.024200832,
0.0012345033,
-0.00395302,
-0.0073254807,
0.0075537907,
0.008525738,
-0.027919019,
0.024018183,
-0.009125866,
0.0057827593,
-0.023952954,
0.009262852,
-0.0071558794,
0.02854524,
0.0035551088,
0.009086727,
-0.0049673673,
-0.02084794,
-0.018395241,
0.011617704,
-0.0018900784,
-0.0103196,
-0.029771589,
-0.0074624666,
-0.016568763,
0.00189334,
0.00011497026,
0.0067318757,
-0.016490486,
-0.0023776828,
0.01658181,
-0.002361375,
0.008858418,
0.008284382,
-0.018721398,
0.0072993883,
-0.0065198736,
0.00019579598,
-0.0077364384,
0.03350282,
-0.03305925,
-0.00411936,
-0.019178018,
-0.013698584,
-0.0104044005,
-0.018290872,
0.00809521,
0.0019618329,
0.0031327356,
-0.0015785987,
0.018303918,
0.008577923,
0.011063238,
0.026718762,
0.010489201,
-0.0030577197,
-0.011395917,
0.015459831,
-0.042139456,
-0.01664704,
-0.021813365,
-0.015120627,
-0.00092057744,
0.0018248471,
0.0037279718,
0.002964765,
-0.00395302,
0.017964715,
-0.009491161,
-0.0034931388,
0.02637956,
0.008473553,
0.003395292,
-0.029902052,
0.0034507385,
0.027344983,
-0.020769663,
-0.010032582,
0.014442221,
0.029014906,
0.021630717,
-0.024305202,
-0.005870822,
-0.005032599,
-0.011265455,
-0.03900835,
0.0034833543,
-0.036999222,
0.025505459,
0.0153293675,
-0.04456606,
-0.041956805,
0.013268057,
-0.012452665,
-0.010593572,
-0.014703147,
-0.015903404,
-0.01724717,
-0.0006029823,
0.009106297,
0.0072602495,
0.03512056,
-0.022361308,
-0.010750127,
0.028258221,
-0.018251732,
-0.0016234453,
-0.016764458,
0.008434414,
-0.024748776,
-0.0041748066,
-0.01868226,
-0.02263528,
-0.00911282,
-0.0062589482,
0.017181939,
0.033007063,
0.015394599,
0.0060534696,
0.024892284,
0.0040769596,
-0.0024119292,
0.022661371,
0.0006184748,
0.01602082,
-0.002428237,
0.0025472844,
0.0293802,
-0.016360024,
0.0021526346,
-0.033241898,
0.004233515,
-0.007612499,
-0.016438302,
-0.012354818,
-0.0065687974,
-0.032250382,
-0.023274546,
-0.0011325794,
-0.013248487,
-0.0068231993,
-0.05236773,
-0.011369824,
-0.008199581,
-0.01142201,
0.009484638,
-0.02043046,
0.014533546,
-0.020195628,
0.02525758,
-0.0052609085,
0.006007808,
-0.0052315546,
-0.023117991,
-0.0063013486,
-0.0041748066,
0.004941275,
-0.018499611,
0.0059230067,
-0.01009129,
-0.0018411549,
-0.0082974285,
-0.0104044005,
-0.024683544,
-0.024879238,
-0.003998682,
-0.018930139,
0.00395302,
-0.016921014,
0.0049869367,
-0.020156488,
-0.0010225015,
0.004924967,
-0.016542671,
0.012054754,
-0.011219793,
-0.01161118,
0.03759935,
-0.013633353,
0.017234124,
-0.028884443,
0.03561632,
0.009145436,
-0.021148004,
-0.030893568,
-0.0014660746,
0.0014603669,
0.004008467,
0.031885084,
0.03942583,
-0.034129042,
-0.011311117,
0.00888451,
0.00008485172,
-0.0061447932,
-0.017286308,
0.025583737,
-0.001048594,
0.009328083,
-0.02105668,
-0.0059230067,
-0.027866835,
0.009021496,
-0.0070188935,
-0.019386757,
-0.012080846,
-0.021213235,
0.0020629414,
-0.006849292,
-0.013724676,
0.02039132,
0.00020160565,
-0.016881874,
-0.015055397,
0.0017009075,
0.001610399,
0.0064611654,
0.0038747424,
0.027397169,
0.021604624,
0.007964748,
-0.0005760744,
-0.0036268632,
-0.00075342215,
0.013300673,
-0.016568763,
0.04096529,
0.009569439,
0.0008847002,
0.023913814,
-0.020026024,
0.006379626,
-0.018982323,
-0.004820597,
-0.023065805,
-0.014103019,
0.002482053,
0.020313043,
0.02494447,
-0.031780716,
0.028179944,
-0.026418697,
0.006474212,
-0.02178727,
-0.011500288,
-0.0035551088,
-0.05802981,
-0.0061447932,
-0.00016419955,
0.024018183,
0.024213878,
0.023013622,
-0.01795167,
-0.0077299154,
0.008127826,
-0.04180025,
0.021591578,
-0.0030691351,
-0.007201541,
-0.0006364134,
-0.009928212,
-0.032850508,
-0.024266062,
0.0010192399,
-0.01980424,
-0.01385514,
0.007684253,
0.0019732483,
0.0077821002,
0.008936696,
-0.016673135,
0.024553081,
0.019752054,
0.0019161709,
0.0022292815,
0.008864941,
0.018956231,
-0.0077299154,
0.011121945,
0.032093827,
-0.008799709,
-0.0005247047,
0.011709028,
0.0068819076,
0.015003211,
0.010065198,
-0.024422618,
-0.011493764,
0.025753338,
-0.014768378,
0.0006131747,
-0.021382837,
-0.008460507,
-0.015681617,
0.016033867,
0.011852536,
-0.0021216497,
-0.014637915,
0.0023776828,
0.00018050738,
0.008975835,
-0.03525102,
-0.016281746,
0.0054207253,
-0.0069601852,
-0.01591645,
0.005482695,
-0.0141421575,
0.012687498,
0.006764491,
-0.008799709,
-0.03780809,
0.0042139455,
-0.036790483,
-0.012654883,
-0.013235441,
0.023809444,
0.012035185,
0.001576968,
-0.018969277,
0.03154588,
-0.0040019434,
0.009393315,
-0.01776902,
-0.036712207,
0.007273296,
-0.011558996,
0.012315679,
-0.008330043,
-0.011917768,
-0.015629431,
0.03420732,
0.005919745,
-0.027057964,
0.024461757,
-0.015094535,
-0.0118133975,
-0.02490533,
0.011389394,
-0.013985602,
-0.003613817,
-0.015838172,
-0.0057697133,
-0.00757336,
0.001818324,
-0.004262869,
0.009680333,
0.03624254,
0.02752763,
-0.007436374,
-0.025935985,
-0.015799034,
-0.03861696,
0.009960827,
-0.0072993883,
0.02515321,
0.031754624,
-0.016320884,
0.028884443,
0.014468314,
0.012648359,
-0.017795114,
0.0011741644,
0.024435665,
-0.015407645,
0.018395241,
-0.032172102,
-0.03480745,
0.016607903,
-0.013346335,
-0.0025896847,
-0.01710366,
-0.026640484,
-0.016764458,
0.0056620813,
0.0011562257,
0.012061277,
0.0139073245,
0.01033917,
-0.03642519,
-0.010502248,
-0.009595532,
-0.005339186,
-0.017286308,
-0.0069145234,
-0.0007729915,
-0.010750127,
-0.013163687,
0.019856423,
-0.0009858088,
-0.018825768,
0.009523777,
0.023731166,
0.19663338,
-0.014024741,
-0.010932774,
0.0155511545,
0.0028946414,
0.0110958535,
0.008643154,
-0.0120417075,
-0.0052152467,
0.0064448575,
0.031102309,
-0.0043868083,
-0.021382837,
0.0031196894,
-0.013163687,
-0.00088796177,
-0.023117991,
-0.0041748066,
-0.0094781155,
-0.0027707017,
-0.018290872,
0.012889715,
0.025857707,
0.016386116,
0.029458478,
-0.009073681,
-0.0065133506,
-0.0090019265,
0.034676988,
0.008512692,
0.00455641,
0.023013622,
-0.016451348,
0.0127396835,
0.00027580632,
0.0043509314,
0.0029093183,
0.0062785177,
-0.013829047,
0.006056731,
-0.017234124,
-0.0015353829,
-0.02885835,
0.0034083382,
0.01504235,
0.024448711,
-0.006705783,
0.0038453883,
-0.0077821002,
0.005694697,
-0.03418123,
-0.009517254,
0.006004546,
0.024957515,
0.01185906,
-0.014781425,
0.010782743,
0.0046575186,
-0.01318978,
0.011826444,
-0.0056098965,
0.008395275,
-0.01283753,
0.03368547,
-0.03326799,
0.03193727,
-0.022465678,
-0.0025228225,
-0.012472235,
-0.010841451,
0.011643796,
-0.01997384,
0.00013484544,
0.0014562899,
-0.013881232,
-0.009739041,
0.018551797,
0.0143769905,
0.013489843,
0.023196269,
-0.0067123063,
0.02581857,
-0.055681482,
0.01924325,
-0.020626154,
-0.036894854,
0.0030348888,
0.005688174,
-0.032198194,
-0.016960151,
-0.0011586719,
-0.010697942,
-0.020691385,
0.026470883,
0.028049482,
-0.00977818,
-0.013091932,
-0.0020662032,
-0.0036170785,
-0.005228293,
-0.021643763,
0.084331095,
-0.019686822,
0.0043411464,
-0.020339135,
0.010450062,
-0.019817285,
0.008512692,
0.012204786,
-0.0038714807,
-0.0073059113,
-0.03861696,
0.0010233169,
-0.032067735,
0.0021395884,
0.035068374,
0.022139521,
-0.0062883026,
0.022922298,
-0.026744854,
0.008590969,
-0.02123933,
0.015094535,
0.0006743291,
-0.014324805,
0.009315037,
-0.016803596,
-0.0011660104,
-0.008264813,
-0.029093184,
0.003936712,
-0.020339135,
0.0014122588,
-0.01720803,
-0.001470967,
-0.00081172265,
-0.0055283573,
-0.012263495,
0.004797766,
0.011898199,
0.0012956577,
-0.012811437,
-0.0108740665,
-0.0113437325,
0.007853854,
0.010795789,
0.013489843,
0.017416772,
-0.007338527,
-0.007377666,
-0.03193727,
-0.012185217,
0.010169568,
-0.02105668,
0.026849225,
-0.027658094,
-0.0034115997,
-0.015172813,
0.0048499512,
-0.00888451,
-0.017925575,
0.0038714807,
0.015094535,
-0.008336567,
0.004050867,
0.010013012,
-0.16313057,
0.026679624,
0.025583737,
-0.017416772,
0.016868828,
-0.0080756415,
0.0031115355,
-0.0073515736,
0.006692737,
-0.0054370333,
0.021708993,
-0.0032517829,
-0.020169534,
-0.0046509956,
0.00549248,
0.00724068,
0.0036823098,
0.038538683,
0.014598777,
0.017742928,
0.015838172,
-0.024670498,
0.008421368,
-0.011976477,
0.0012948423,
-0.012720114,
0.0009474854,
0.0073254807,
0.010293507,
-0.00040728826,
-0.028675703,
-0.010619665,
0.043470174,
-0.0034409538,
-0.010130429,
0.010906682,
-0.010084767,
-0.039686754,
0.003861696,
0.00767773,
0.040573902,
0.027866835,
0.009256329,
0.011454626,
-0.027449353,
0.030058607,
0.01955636,
0.012935378,
0.013659446,
-0.001610399,
0.018577889,
-0.015785987,
0.01577294,
0.014990165,
-0.025766384,
0.002398883,
-0.009510731,
0.00018173047,
0.008949742,
-0.018069085,
-0.0013103348,
-0.017925575,
-0.003447477,
0.0108871125,
0.022061244,
-0.020234765,
-0.00790604,
0.019582452,
-0.005779498,
-0.000102076876,
0.00077829155,
-0.0293802,
0.012139555,
-0.012439619,
0.02721452,
0.0029598726,
-0.025962079,
-0.0022472201,
-0.00041360754,
0.0073972354,
-0.0054076794,
0.01766465,
-0.020443507,
0.01161118,
-0.0030821813,
0.01924325,
0.012054754,
0.009523777,
-0.027814649,
-0.023874676,
0.025322812,
-0.023731166,
0.0050586914,
0.0072993883,
-0.0063111335,
0.02521844,
-0.00318329,
-0.008082164,
-0.008858418,
-0.0041487142,
0.011898199,
-0.0069080004,
-0.032302566,
0.0001508475,
0.05184588,
0.005290263,
-0.021461114,
-0.001421228,
0.036007706,
-0.018590936,
0.00012230879,
0.016620949,
0.0059164837,
0.03438997,
-0.007899517,
0.019634638,
0.005531619,
-0.010463109,
0.000052541815,
-0.038538683,
0.07629459,
-0.02270051,
-0.0075929295,
0.023979045,
-0.034285598,
-0.016112145,
-0.13317633,
-0.00592953,
0.0039954204,
0.036477372,
-0.0012459188,
0.016164329,
-0.020299997,
0.0038910501,
0.00015706486,
0.017860344,
-0.00036346095,
0.002436391,
-0.017964715,
0.0075994525,
0.038147297,
-0.0036986177,
-0.005968669,
-0.023744212,
-0.009510731,
0.02700578,
0.010169568,
-0.015668571,
0.022165613,
-0.008695339,
0.0122895865,
-0.019595498,
-0.019699868,
0.023352824,
0.014598777,
0.01833001,
0.012563558,
-0.008864941,
0.009823842,
-0.007181972,
-0.021448068,
-0.028388685,
-0.009288944,
-0.031258862,
0.02224389,
-0.0024771607,
0.0017645081,
0.014194342,
0.0054631256,
-0.028623518,
0.009047588,
0.019686822,
-0.03154588,
0.0036464327,
0.008473553,
-0.027397169,
0.009171528,
-0.03480745,
-0.029954238,
-0.022557002,
0.013424613,
0.005313094,
0.0049901986,
0.0402347,
-0.0071493564,
-0.0049901986,
-0.029693311,
0.010136953,
-0.015785987,
0.033711564,
-0.0066503366,
-0.037234057,
-0.005877345,
-0.030867476,
0.0019129094,
-0.016633995,
-0.011532903,
-0.0075016054,
-0.01647744,
-0.024161693,
-0.012028662,
0.009432454,
-0.012302633,
-0.018525705,
0.009060635,
-0.017155847,
-0.0020710954,
-0.008695339,
0.010502248,
-0.013385474,
0.021669855,
0.035042282,
0.004957583,
-0.008864941,
0.00565882,
-0.00065109046,
-0.004999983,
0.043965932,
0.021839457,
-0.007971271,
0.002904426,
0.005521834,
-0.021669855,
-0.027266705,
0.019191064,
0.013385474,
-0.022374354,
-0.015290229,
-0.047201406,
0.014703147,
-0.00051125075,
0.011695982,
0.0047879815,
-0.018251732,
-0.0048336433,
-0.010306554,
0.026614392,
0.02987596,
-0.023000576,
0.028780073,
-0.0021265422,
-0.004862997,
-0.0056392504,
-0.0019178018,
0.05330706,
0.03266786,
0.0265883,
0.019843377,
-0.010437016,
0.019960795,
-0.00790604,
0.02423997,
-0.008245243,
-0.0300847,
0.0008365921,
0.0104044005,
-0.0054272483,
-0.0062426403,
-0.0041650217,
-0.02581857,
-0.00703194,
-0.014129111,
0.00482712,
-0.045192283,
-0.007847331,
0.02263528,
0.008682293,
0.018303918,
0.005975192,
-0.016960151,
0.013268057,
-0.0019471559,
0.008571399,
0.0059719305,
-0.022674419,
0.019960795,
0.0136855375,
-0.0036496941,
0.017612465,
-0.007566837,
0.020208674,
-0.043287527,
-0.020352183,
0.014650961,
0.009067158,
-0.005482695,
0.020704431,
-0.018969277,
0.02644479,
0.035668503,
-0.010273938,
0.0015565831,
0.019282388,
0.0022977744,
-0.0044944403,
0.019086694,
0.011598134,
-0.0051891543,
-0.012680975,
-0.03590334,
0.0005825975,
0.0017645081,
0.026875317,
0.0047945045,
-0.005061953,
-0.0057142666,
0.019543312,
0.023887722,
0.026627438,
0.013933417,
-0.024644405,
0.008395275,
0.02823213,
0.016542671,
-0.02067834,
0.010724034,
0.004716227,
0.010286984,
-0.028493054,
0.0032110133,
0.0018868169,
-0.0014326436,
0.019999932,
0.011852536,
0.009184575,
0.022413492,
0.0060175923,
0.036999222,
-0.02193078,
0.0010844712,
-0.016125191,
-0.023313686,
-0.007997364,
-0.011793829,
-0.02284402,
-0.03162416,
-0.01997384,
0.0021020803,
0.0034115997,
0.0017530926,
-0.025348904,
-0.008460507,
-0.006894954,
0.008453983,
-0.021630717,
-0.00006991986,
-0.008708386,
0.024370434,
0.0030153194,
0.0054892185,
-0.012015616,
0.013724676,
-0.0061578397,
-0.0017808159,
-0.002240697,
-0.0020107564,
0.007651638,
0.0026304543,
0.010998006,
0.015120627,
-0.032093827,
0.003757326,
0.010789266,
-0.010932774,
0.015368506,
0.011676412,
0.009908643,
0.08725346,
0.009889073,
-0.023378916,
0.022087336,
-0.019034509,
0.002488576,
0.0008569769,
-0.010032582,
-0.009843411,
-0.008936696,
0.005635989,
-0.015785987,
-0.0017270001,
-0.048349477,
-0.021134958,
0.0014326436,
0.0020710954,
0.0022716818,
0.0062361173,
-0.02049569,
0.015238044,
-0.012446142,
0.0008912234,
-0.011682935,
-0.020352183,
0.00746899,
0.02998033,
-0.009686856,
0.0022276507,
-0.02823213,
0.00669926,
0.009412884,
-0.010065198,
-0.014011694,
0.024957515,
-0.0120482305,
-0.017064521,
-0.01591645,
0.007266773,
0.018356103,
-0.016255653,
0.01703843,
-0.03159807,
-0.0077690543,
-0.009823842,
-0.016947106,
-0.0056066345,
-0.0048238584,
-0.0021395884
] |
The phosphatidylinositol-3-kinase-like kinase ATM (ataxia-telangiectasia mutated) has a central role in coordinating DNA damage responses, including cell-cycle checkpoint control, DNA repair and apoptosis. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer predisposition. However, the mechanism by which DNA damage activates ATM is poorly understood. Here we show that Cdk5 (cyclin-dependent kinase 5), activated by DNA damage, directly phosphorylates ATM at Ser 794 in post-mitotic neurons. Phosphorylation at Ser 794 precedes, and is required | [
-0.034582783,
-0.016346794,
-0.0132440515,
-0.025464788,
-0.05620358,
0.034740217,
-0.033953052,
0.02656682,
-0.0041719745,
0.01237161,
0.028547851,
0.007996284,
-0.00337497,
0.027026,
-0.0025943648,
0.0042178924,
0.03062072,
-0.00674994,
-0.014247687,
0.005582312,
-0.027891882,
0.027183432,
0.0022368606,
-0.017278273,
0.011230221,
0.021122262,
-0.012535603,
-0.035920963,
-0.0072747166,
-0.013375246,
-0.003689836,
0.00021790533,
-0.004700031,
-0.000495668,
0.0020236701,
0.0069008134,
0.009892041,
-0.012745514,
0.008193076,
-0.022001263,
-0.008061882,
0.0021794632,
0.0041096574,
-0.010370899,
-0.0025582863,
0.007084485,
0.012909506,
-0.018747646,
-0.014588792,
0.006241563,
-0.0017891605,
0.010554571,
-0.033165887,
-0.014050895,
-0.02274907,
-0.015822018,
0.005362562,
0.01193867,
-0.00004161315,
-0.002633723,
-0.01733075,
-0.005339603,
-0.014496956,
0.027078478,
0.0011512289,
0.015166046,
0.00899992,
0.023601832,
0.001011015,
0.012437208,
0.04360894,
0.03132917,
-0.0074387095,
-0.012961984,
0.013985299,
-0.03125045,
-0.0193905,
-0.016150003,
-0.027078478,
0.030069703,
0.027104715,
-0.005067375,
0.022617875,
0.01868205,
0.008435785,
-0.0006485912,
-0.015454673,
0.0130538205,
0.034582783,
0.010101952,
0.013644194,
0.004870584,
0.020072708,
0.014260806,
-0.01889196,
0.014824942,
0.0060513313,
0.0224998,
-0.025582863,
-0.026186356,
-0.028154269,
0.003535683,
0.010456176,
-0.010515213,
-0.029649884,
0.0067433803,
0.014864299,
-0.0030961824,
0.014077134,
-0.007156642,
-0.0077994936,
0.023155771,
-0.009531257,
-0.033192124,
0.00854074,
-0.009505018,
-0.0017514422,
0.0063137193,
-0.02860033,
-0.0024828496,
0.023575593,
0.051847935,
0.012929185,
-0.012306013,
0.009505018,
0.0076420605,
-0.014995494,
0.00812092,
-0.010220026,
-0.0007326375,
0.004099818,
0.018616453,
0.020453172,
-0.014247687,
-0.03442535,
0.0047361096,
-0.020151425,
-0.0024254522,
-0.027288388,
-0.050116174,
0.0061300476,
0.018839482,
-0.024428355,
0.010921915,
-0.008048763,
0.008665375,
0.012981663,
0.016110644,
0.0006014433,
0.0073993513,
0.017002765,
0.008481703,
0.011859953,
-0.022460442,
-0.012811111,
0.0065662684,
-0.010869437,
0.010285623,
-0.0036996757,
-0.036550697,
0.009196712,
-0.0030912627,
-0.0064088353,
-0.0019269144,
0.039804313,
0.024257801,
-0.0005887338,
0.012889828,
0.004411404,
-0.023063935,
-0.0041424558,
0.028390419,
-0.024218444,
0.016123764,
-0.02251292,
0.012955424,
0.0023762544,
0.023864219,
-0.025595983,
-0.007497747,
0.0020597484,
0.02833794,
0.02452019,
0.007005769,
-0.009058958,
0.0007092685,
0.020610604,
-0.009570614,
0.0062546823,
-0.023693668,
0.002545167,
0.008206195,
-0.022644114,
-0.017461944,
-0.6255338,
-0.013230932,
-0.005765984,
-0.0057102265,
0.009373823,
0.052320234,
0.014365762,
0.0071238433,
-0.008396427,
-0.0012110862,
-0.004637714,
-0.0021991422,
0.006412115,
-0.01645175,
-0.04140488,
-0.030673197,
0.0050772144,
-0.019338021,
0.027026,
0.008252113,
-0.013486761,
0.010561131,
-0.010823519,
0.0012725835,
-0.017514423,
0.014562553,
0.025477909,
-0.019954633,
-0.014523195,
0.024835058,
-0.02428404,
0.007340314,
-0.006999209,
0.026842328,
0.038413655,
-0.001979392,
0.006887694,
0.02005959,
-0.0127192745,
0.042664345,
-0.012975103,
-0.011433572,
0.019534811,
0.00061087287,
0.0013357206,
0.007943807,
0.010692325,
-0.01643863,
0.00050919736,
-0.0035652015,
0.016071286,
-0.01011507,
-0.010928474,
0.012837349,
-0.0023073775,
0.028731523,
0.015362837,
-0.01014787,
0.021292813,
0.022184934,
-0.016150003,
0.026514342,
-0.005306804,
-0.011341736,
-0.008455465,
0.006881134,
-0.008252113,
0.013421164,
0.0053494424,
-0.015494032,
0.051349398,
0.016018808,
-0.0072747166,
0.005064095,
-0.012765192,
0.016163122,
0.0045852363,
0.023313204,
0.0012438848,
0.015572748,
-0.0097870855,
-0.02522864,
-0.015297241,
0.0072287987,
0.01667478,
0.015257882,
-0.010751362,
0.013604836,
-0.013749149,
0.009078637,
0.0128635885,
-0.028521612,
-0.010561131,
-0.028784001,
-0.01714708,
0.005985734,
-0.006185805,
-0.0029977867,
-0.009157353,
-0.027104715,
-0.014064015,
0.013217812,
-0.02137153,
-0.0024598907,
0.019246185,
0.0055724722,
-0.035186276,
0.0009659171,
0.054052,
-0.024126608,
-0.016359914,
0.0003419248,
0.01777681,
0.0033257722,
0.013086619,
-0.021660158,
0.031145496,
0.0073993513,
0.0070320074,
-0.012738954,
-0.0147462245,
-0.0060906895,
0.017304512,
-0.028023075,
0.03392681,
0.0075108665,
0.012699596,
-0.01799984,
0.017212676,
0.00025295877,
-0.0050083376,
-0.0057233456,
0.017435705,
-0.021542083,
0.016858451,
-0.01283079,
-0.003312653,
-0.003443847,
0.008134038,
-0.027944358,
-0.032536153,
-0.014785583,
-0.0033618507,
0.0010708724,
-0.015047971,
-0.0041293367,
-0.014142732,
-0.0029846674,
0.0059988536,
0.017304512,
0.012857029,
0.005021457,
-0.0018137594,
0.01781617,
0.018393423,
-0.008691614,
0.004450762,
-0.024493951,
-0.005313364,
-0.018865721,
-0.0023680548,
0.013335887,
-0.017055241,
-0.002614044,
-0.0048115463,
-0.016084405,
0.0008158638,
0.012633999,
-0.019311782,
-0.030043466,
-0.020007111,
-0.02187007,
-0.02230301,
0.001238965,
0.007858531,
0.042952973,
0.015677704,
-0.018931318,
-0.012804551,
0.008179957,
0.0014685547,
-0.018747646,
-0.006664664,
-0.02294586,
0.011715639,
0.034950126,
0.026028924,
0.008416106,
-0.001193047,
0.039463207,
-0.015467793,
0.0069795297,
0.004886983,
0.00832427,
0.019298663,
-0.007045127,
0.0121617,
-0.010246265,
-0.020912351,
0.04502584,
0.008842487,
-0.018183513,
0.015047971,
0.0036635972,
0.0034372872,
-0.016622301,
-0.005421599,
-0.024152847,
0.008468584,
0.008409547,
-0.015782658,
0.0001081327,
-0.008652256,
-0.008291472,
0.005510155,
0.0031683391,
0.0016546865,
-0.014496956,
-0.0011438492,
-0.013093178,
-0.0018268789,
-0.0023696946,
0.014208329,
-0.0135785965,
0.015861375,
0.020846754,
0.0081078,
0.04011918,
0.0006162026,
-0.0018399983,
-0.013827866,
0.011984588,
-0.015034852,
0.016359914,
0.0028551132,
0.011735318,
-0.0034569665,
-0.0044048443,
0.039227057,
0.0012397849,
0.0017858807,
0.002095827,
-0.012942305,
-0.023693668,
-0.003991583,
-0.013985299,
0.04570805,
0.033454515,
-0.0022073418,
-0.0035455225,
-0.012627439,
0.012948865,
-0.014090254,
-0.0010610329,
-0.008048763,
-0.005421599,
0.012502804,
0.017540662,
0.024848176,
0.018747646,
0.024021653,
-0.010482415,
0.015480912,
0.008678494,
0.017619377,
0.0064875516,
0.021528963,
0.0061366074,
-0.030279614,
-0.004519639,
-0.001327521,
-0.0034241679,
0.008967122,
-0.03720667,
0.017658735,
0.011446691,
-0.0041522956,
0.008186516,
0.0042178924,
-0.008527621,
0.00050591753,
-0.046678886,
0.029728599,
0.03762649,
-0.0072353585,
0.0012570041,
-0.018209752,
-0.014457597,
0.00004440615,
0.01643863,
-0.012082983,
0.029282538,
-0.006999209,
-0.0008076641,
-0.02046629,
-0.04413372,
0.026947282,
-0.02860033,
0.023575593,
-0.0038538289,
0.0051657706,
0.013408044,
-0.008914644,
-0.0099051595,
0.03439911,
0.0147462245,
0.018577095,
-0.007740456,
-0.0058643795,
-0.03306093,
0.009839563,
-0.02070244,
0.0062284432,
-0.015021733,
-0.009623093,
-0.010357779,
0.028180508,
-0.003219177,
0.030673197,
0.019915275,
-0.029335016,
-0.011518848,
-0.006143167,
-0.017029004,
0.031853944,
0.029203823,
-0.003781672,
0.011413893,
-0.011682841,
0.008685054,
-0.010875997,
-0.015900733,
0.037416577,
-0.01848526,
-0.0054379986,
-0.013158775,
0.007222239,
0.004096538,
0.02159456,
0.02568782,
0.006366197,
0.00068097975,
-0.004775468,
-0.008612897,
-0.0034077687,
-0.004978819,
0.031197974,
0.039332014,
0.033323318,
0.0026894805,
0.0016809254,
0.027340865,
0.017842406,
-0.022342367,
-0.008763771,
0.01373603,
0.005720066,
0.017671855,
-0.00078019535,
-0.021227216,
-0.0051788897,
0.026750492,
0.010928474,
0.011584445,
0.027078478,
-0.011171184,
0.0023975736,
0.009203271,
0.0075699035,
-0.026225714,
0.025923967,
0.013355566,
-0.015900733,
-0.0033716902,
0.008822808,
-0.015717061,
-0.03447783,
-0.03151284,
0.01056769,
0.0010971113,
0.0006371117,
-0.015284121,
-0.0059496555,
0.0026025644,
-0.0071238433,
-0.014116493,
-0.00033249523,
-0.0050148973,
-0.003712795,
0.0021319052,
-0.0030765033,
-0.019889036,
-0.028075553,
-0.018878842,
-0.0025566465,
-0.02270971,
-0.03712795,
-0.0063793166,
0.044973362,
0.017763691,
0.010902235,
-0.013421164,
-0.014615031,
0.04164103,
-0.025740296,
-0.021896306,
-0.013007903,
-0.019679125,
-0.011787796,
0.020518769,
0.013099738,
-0.01418209,
0.005808622,
0.034267917,
0.017291391,
-0.009990436,
0.022486681,
-0.00901304,
-0.0075961426,
0.022591636,
0.022434203,
0.041378643,
0.0018039199,
0.009295107,
0.0003240906,
-0.026540581,
-0.0073075155,
-0.029754838,
-0.009432861,
-0.031381644,
0.006841776,
0.012489685,
0.012430647,
-0.01643863,
-0.017356988,
0.0061562867,
-0.000540766,
-0.013473641,
0.016464869,
0.025923967,
0.02138465,
0.012627439,
-0.020715559,
0.013617955,
-0.011446691,
-0.02093859,
0.01485118,
0.015100449,
-0.00047229903,
0.017055241,
0.033690665,
-0.02497937,
-0.013152216,
-0.0032634551,
0.0066515445,
0.014142732,
-0.0015128328,
-0.04484217,
0.0064416337,
-0.004224452,
-0.0051395316,
-0.0061792457,
0.016569823,
0.00050509756,
-0.0049689794,
0.00337497,
0.00058504404,
-0.011630363,
0.008134038,
-0.034110483,
-0.013486761,
0.0243234,
-0.0062612416,
0.019547932,
-0.0069008134,
0.0033503713,
-0.024008533,
-0.0023549353,
-0.025491027,
-0.03376938,
0.0154153155,
0.003417608,
0.023090174,
0.023601832,
0.023575593,
0.0055232747,
0.015953211,
0.014077134,
0.0065662684,
-0.027708208,
-0.010226586,
0.00092655886,
-0.008855606,
0.021017306,
-0.012312573,
-0.012883267,
0.022932742,
-0.016123764,
0.014995494,
0.019010035,
0.003535683,
-0.02431028,
0.014037777,
-0.03870228,
-0.013198134,
0.015139807,
-0.03130293,
-0.020413812,
-0.02495313,
0.017514423,
0.022224292,
0.009951078,
0.012916066,
-0.0076814187,
0.018931318,
-0.0112892585,
0.010974392,
-0.004542598,
0.040906344,
-0.008435785,
-0.025727177,
0.0054970356,
0.009150794,
0.023903579,
0.01798672,
0.01645175,
-0.004611475,
0.0049820985,
-0.021109141,
0.023890458,
-0.020649962,
-0.013591716,
-0.027288388,
-0.03597344,
-0.015389076,
-0.011682841,
-0.013447403,
-0.028888956,
0.010915355,
0.00540848,
-0.029125106,
0.016897809,
0.0073206346,
-0.0070516868,
0.027157193,
0.0026206037,
0.010967833,
-0.020689322,
0.018380303,
0.0044442024,
0.017619377,
-0.007956927,
-0.012063304,
-0.019967753,
0.011918991,
0.03285102,
0.008914644,
-0.017645616,
-0.024966251,
-0.0018186792,
-0.011177744,
-0.02025638,
-0.024926893,
0.004253971,
-0.014549433,
0.0069795297,
0.0051887296,
-0.0035980002,
-0.012365051,
0.015061091,
-0.0005916037,
0.01531036,
0.0007900349,
-0.010324981,
-0.015546509,
0.0014275566,
-0.0001306817,
0.025504148,
-0.0036832765,
-0.022854025,
0.012424088,
-0.0006465413,
0.007038567,
0.00292727,
-0.003196218,
0.020754918,
-0.023431279,
0.0043294076,
0.0033684103,
-0.0007711757,
0.0037718324,
0.0036799966,
0.0084292255,
0.03854485,
-0.0064514736,
-0.0074452693,
0.011413893,
-0.004067019,
-0.0064645926,
0.018983796,
0.004522919,
-0.015284121,
-0.037678964,
-0.005601991,
0.008763771,
-0.0065892274,
0.012515924,
-0.0014841341,
-0.027130954,
-0.0018727968,
-0.008291472,
-0.007091045,
0.023798622,
-0.053894565,
-0.016517347,
-0.005132972,
-0.0013750789,
0.0044901203,
0.03400553,
0.021856949,
-0.0036767167,
0.029781077,
0.0062907604,
-0.0012578241,
0.019180588,
-0.022237413,
-0.0121617,
0.015730182,
-0.0059266966,
-0.011505729,
0.004929621,
-0.00066704035,
-0.03219505,
-0.00046204947,
-0.0046803523,
0.018052317,
0.019193707,
-0.025700938,
0.025412312,
-0.0030141862,
0.008744092,
0.015231643,
-0.020164544,
0.01102031,
-0.05064095,
-0.006189085,
0.042664345,
-0.0047361096,
-0.031801466,
-0.013513,
-0.01440512,
0.004076859,
-0.0004481101,
-0.020872993,
-0.020676201,
0.0012274855,
-0.0034110486,
0.002969908,
-0.001214366,
-0.0035947203,
-0.020794276,
0.015428434,
0.01440512,
-0.0033684103,
-0.0057331854,
0.024900654,
0.012397849,
0.022263652,
-0.022932742,
0.0052313674,
-0.0066974624,
-0.03649822,
-0.04077515,
-0.0044638817,
-0.034740217,
0.014864299,
0.018590214,
0.0120764235,
-0.015992569,
-0.010423377,
-0.04431739,
-0.018275348,
-0.01617624,
-0.010397138,
0.013945941,
0.018091677,
-0.012640558,
-0.005136252,
0.0014619951,
0.02545167,
-0.001260284,
0.0027419582,
0.025084326,
-0.019141229,
0.021187859,
-0.016045047,
-0.009485339,
-0.013801627,
0.00040916182,
-0.005359282,
-0.018131034,
0.018616453,
-0.004388445,
0.007917568,
0.00021298554,
0.006999209,
0.00025787854,
0.01956105,
0.012214177,
-0.023772383,
-0.010423377,
0.0037423137,
0.014444478,
-0.008376748,
0.011781236,
0.008750651,
-0.0028009955,
0.009137674,
-0.025556624,
-0.035238754,
0.0007268977,
-0.021266576,
0.022079978,
0.02116162,
0.010521772,
0.013375246,
-0.009793645,
-0.018603334,
-0.0070648063,
-0.026081402,
-0.03382186,
-0.0065269102,
-0.0039522243,
0.017002765,
-0.0011397493,
-0.0024664504,
-0.0014095174,
-0.019193707,
-0.0100494735,
0.011807475,
-0.007622381,
-0.030909346,
0.01889196,
-0.0052740057,
-0.011138385,
0.0036406382,
0.0066974624,
-0.01597945,
-0.03563234,
-0.0018596774,
0.003466806,
-0.009413182,
-0.020886112,
0.008278352,
-0.00269932,
0.009163913,
0.009144234,
-0.02295898,
-0.014378881,
0.019442976,
0.20130433,
-0.0003349551,
-0.013972179,
0.0063793166,
0.005946376,
0.009511577,
0.014562553,
-0.005759424,
-0.040014222,
-0.0062546823,
0.012023946,
0.010259384,
0.008376748,
-0.0034241679,
0.019141229,
0.0045852363,
0.009537816,
-0.004818106,
-0.009439421,
-0.012542163,
0.031853944,
-0.023785504,
0.0062546823,
0.021909427,
0.024179086,
0.0015152927,
-0.011984588,
-0.001217646,
0.033139646,
-0.01012819,
-0.043477748,
0.016359914,
0.01237161,
-0.016937168,
0.0138409855,
-0.012778312,
-0.033559468,
-0.032536153,
0.012312573,
-0.01868205,
-0.003109302,
-0.0015480912,
-0.008901524,
-0.0067237015,
-0.03492389,
0.0043130084,
0.008868726,
-0.027629493,
-0.0105020935,
0.009255749,
-0.054104477,
-0.0138409855,
-0.003935825,
0.008061882,
-0.019915275,
-0.0084292255,
0.018039199,
-0.007071366,
-0.013375246,
0.03329708,
0.0059758946,
-0.004257251,
-0.020098947,
0.00924263,
-0.029151345,
0.012981663,
-0.029571166,
0.014916778,
0.043084167,
-0.037469056,
-0.002143385,
-0.004345807,
-0.00203023,
-0.017356988,
-0.013027581,
-0.013355566,
0.027078478,
0.0057233456,
0.01845902,
0.008744092,
0.009131114,
0.006684343,
-0.015612107,
0.0107644815,
0.014969255,
-0.020282619,
0.028784001,
0.007110724,
-0.0037488735,
-0.013191574,
-0.00015251322,
-0.010712004,
-0.013722911,
0.005221528,
-0.005969335,
-0.0049853786,
0.012115782,
0.000720338,
-0.014575672,
-0.004657393,
-0.020518769,
0.0634455,
-0.022093099,
-0.011230221,
-0.010180668,
0.0077076578,
-0.015467793,
0.02089923,
-0.006710582,
-0.04318912,
0.0022860584,
-0.012240416,
0.017304512,
0.0030519045,
-0.0126012005,
0.008803129,
-0.0056151105,
-0.0059037376,
0.025254877,
-0.023247607,
0.0041588554,
-0.048594322,
-0.013526119,
0.04384509,
0.009747727,
-0.008376748,
-0.05767296,
-0.0018153994,
0.0010684126,
-0.03151284,
0.012358491,
0.01102031,
0.010895676,
0.019036274,
-0.018537736,
0.00016337774,
0.01532348,
-0.030778153,
-0.0037226346,
0.01872141,
-0.0019662727,
-0.0054740766,
0.010410258,
0.00085194217,
0.0016095885,
-0.01958729,
0.007694538,
0.020072708,
-0.037337862,
-0.021542083,
-0.019495454,
-0.0058250213,
0.0023729745,
0.016084405,
0.004388445,
-0.025477909,
0.0033028133,
-0.023024578,
0.0010962914,
0.018196631,
-0.006349798,
0.014273926,
0.00879001,
0.004929621,
-0.011367975,
0.011774677,
-0.16352041,
0.0052084085,
-0.0021778233,
-0.028390419,
0.03893843,
0.03442535,
0.03308717,
0.008855606,
-0.0022024221,
0.016123764,
0.02204062,
0.005923417,
-0.03397929,
-0.014221448,
0.020440051,
0.008639136,
0.008973681,
0.031014303,
0.007071366,
-0.00016255777,
0.0118140355,
-0.0044638817,
0.021988142,
0.0069664107,
0.0028321543,
0.027445821,
-0.017737452,
-0.01643863,
-0.017225794,
-0.005510155,
-0.010974392,
0.0057036667,
0.032693587,
-0.002607484,
0.016858451,
0.010141309,
0.0044310833,
-0.010508653,
-0.006553149,
0.006707302,
0.029282538,
0.036576934,
0.008245554,
-0.005431439,
0.001307022,
0.04208709,
0.0045097996,
-0.011846834,
0.018170392,
-0.029230062,
0.0467576,
-0.02070244,
0.007156642,
0.022591636,
0.019705364,
0.012128901,
-0.023142653,
-0.009846123,
0.011099027,
-0.0067827385,
0.0012988223,
0.008462024,
0.024244683,
-0.010705444,
-0.004099818,
-0.035947204,
-0.010593929,
0.006015253,
-0.037705205,
0.019941514,
-0.020649962,
-0.0049427403,
0.031748988,
-0.02273595,
-0.0018662371,
0.0008035643,
-0.013513,
0.010915355,
-0.0026845608,
-0.010357779,
-0.017881766,
0.031906422,
-0.030017227,
-0.027734447,
-0.013289969,
-0.0002092957,
0.0042736502,
0.015192285,
-0.0046278746,
-0.0072353585,
0.0054970356,
-0.018209752,
0.0023713347,
-0.01822287,
0.029466212,
0.028442897,
-0.017593138,
0.00045016,
0.0113614155,
0.018511498,
0.0035422426,
0.0017612817,
-0.013814746,
0.011453251,
0.023011457,
0.0036307988,
0.006868015,
0.0046705124,
0.030200899,
0.0138409855,
-0.012870148,
-0.021909427,
0.011190862,
0.029282538,
0.016254958,
0.0023254168,
-0.009400062,
0.0037160749,
-0.020177664,
-0.010154429,
0.06622682,
0.0005469157,
-0.019784082,
0.019167468,
0.0049165017,
-0.027865643,
-0.13024957,
-0.012673357,
-0.0010667726,
0.02568782,
0.008704733,
-0.0073731123,
0.006730261,
0.04484217,
-0.013473641,
0.042401955,
-0.053658415,
-0.025438549,
-0.0005153471,
0.004598356,
-0.013709791,
-0.015179166,
0.024139728,
-0.014496956,
-0.0046705124,
0.023024578,
-0.0045786765,
-0.00080233434,
-0.0026484823,
-0.012837349,
-0.023037696,
-0.0006334219,
-0.04116873,
0.025149923,
0.021515844,
0.019875918,
0.00073755725,
-0.012515924,
0.010954713,
-0.008252113,
-0.0373641,
0.0041358965,
-0.019836558,
-0.030725675,
0.049197815,
0.009019599,
-0.008888405,
0.0007519066,
0.03224753,
-0.001170908,
0.030200899,
-0.0026501222,
-0.019915275,
0.0065367497,
-0.0013824586,
-0.010377459,
-0.02542543,
0.0040899785,
-0.026973521,
0.006149727,
0.007359993,
-0.030463286,
0.005290405,
0.010482415,
0.0066220257,
-0.0152710015,
0.011630363,
-0.012194498,
0.015192285,
-0.003735754,
0.038859714,
-0.025333595,
-0.0148905385,
-0.035527382,
0.042900495,
-0.0021237056,
0.000540356,
0.005805342,
-0.016569823,
-0.010003556,
-0.016963406,
-0.00810124,
-0.0057725436,
-0.0075305454,
-0.006280921,
0.00006805698,
-0.020072708,
-0.012706156,
0.018065438,
-0.008081561,
0.022079978,
-0.009308226,
0.00047393894,
-0.014431359,
0.01170252,
-0.015139807,
0.0010306942,
0.031460363,
-0.018839482,
0.0013562198,
-0.01869517,
0.01960041,
0.00224834,
-0.02096483,
-0.0005706946,
0.02364119,
-0.019993993,
-0.0022188213,
-0.055311464,
0.009065517,
0.018131034,
-0.0027960758,
-0.011781236,
-0.010449615,
0.012246976,
-0.01103343,
0.019613529,
0.019666007,
-0.010875997,
0.0063629174,
-0.013427723,
-0.0074387095,
-0.028731523,
-0.006661384,
0.035842247,
-0.019141229,
0.014234568,
0.029859794,
-0.019482335,
-0.021542083,
0.013270291,
0.0042408514,
0.024507072,
-0.0034536866,
-0.02116162,
0.002996147,
-0.010790721,
0.010810399,
0.013801627,
-0.04507832,
-0.009498458,
0.0016825652,
0.0038374295,
-0.022801546,
-0.039620638,
0.006887694,
0.014929897,
0.017094601,
-0.01935114,
-0.021279695,
0.013827866,
-0.0043589263,
-0.017711213,
0.0006227623,
-0.026251953,
-0.00023225468,
0.009537816,
-0.029230062,
0.04326784,
0.012640558,
0.005339603,
-0.011505729,
-0.011282699,
-0.014864299,
0.00788477,
-0.013565477,
-0.004706591,
-0.02495313,
-0.0010946514,
0.006553149,
0.028154269,
0.0075764633,
0.005087054,
0.001959713,
-0.034740217,
-0.0011069508,
-0.012850469,
-0.045839243,
0.00025193382,
0.030253377,
0.0121617,
-0.0057299053,
-0.017973602,
-0.021109141,
-0.011322057,
-0.013814746,
-0.0030322252,
-0.006166126,
0.011125266,
0.027760686,
-0.021279695,
0.0139590595,
0.023536235,
-0.022014381,
-0.008763771,
0.024257801,
0.012647118,
0.020440051,
-0.011059669,
0.012568401,
0.010921915,
0.0056315097,
0.005041136,
0.03287726,
-0.01777681,
-0.008796569,
0.0011504089,
0.039961744,
0.018275348,
-0.007747016,
-0.002540247,
-0.0037390338,
0.0010052753,
0.039909266,
-0.038413655,
-0.04227076,
-0.008252113,
-0.008750651,
0.018629571,
0.019849679,
0.029833555,
0.0059890137,
-0.00097001693,
0.0077994936,
0.011433572,
0.02096483,
-0.0010495534,
0.01125646,
0.006346518,
0.005969335,
0.0037062354,
0.005611831,
0.02812803,
0.0019219946,
0.020308858,
-0.018590214,
0.025477909,
-0.013211253,
0.049696352,
0.016031928,
-0.03896467,
-0.008468584,
-0.00315358,
-0.018616453,
0.0046869116,
0.03668189,
-0.009609973,
0.089946724,
0.0011151504,
-0.0116238035,
-0.0154153155,
-0.021305934,
0.0077601355,
-0.0040866984,
-0.00630716,
-0.02857409,
-0.028757762,
0.016464869,
-0.014273926,
0.032536153,
-0.021922546,
-0.0059955735,
0.02046629,
-0.01485118,
0.000653511,
0.021751994,
-0.040801387,
0.019915275,
-0.01802608,
0.0035717613,
0.027052239,
-0.00922295,
-0.00007338674,
0.019495454,
0.0024598907,
0.01645175,
-0.056465972,
0.011407333,
-0.0329035,
-0.027419582,
0.0063596372,
0.01081696,
-0.015507151,
0.006953291,
-0.025491027,
0.024257801,
0.023733025,
-0.007996284,
-0.0040112617,
-0.0022794986,
-0.036996756,
0.014077134,
-0.006631865,
0.005713506,
-0.013086619,
-0.0067630596
] |
1. Nitric oxide (NO) has been suggested as a gastrointestinal neurotransmitter, mediating the gastric receptive relaxation and the relaxation in the peristaltic reflex. The aim of the present study was to measure nerve-induced NO formation in vivo in the gastrointestinal tract. 2. Formation of the nitric oxide oxidation products nitrite and nitrate during vagal nerve stimulation were measured in the anaesthetized rabbit. Microdialysis probes were inserted into the wall of the stomach and proximal colon, and nitrite and nitrate in dialysate measured by capillary electrophoresis. 3. During bilateral vag | [
-0.0300788,
0.005142938,
0.019497508,
-0.010520866,
-0.0098494645,
0.008721509,
-0.018960387,
-0.031824443,
-0.015509382,
-0.01271635,
0.003021308,
0.01261564,
-0.018772393,
-0.0055088517,
-0.013777165,
-0.015187109,
0.04216403,
0.00004752266,
0.010930421,
0.0065092403,
0.0061668255,
0.026386091,
-0.003357009,
0.0001461348,
0.010655146,
0.015952507,
0.008332096,
-0.028897133,
-0.009728612,
0.0018245344,
-0.0039008444,
0.005653203,
-0.01585851,
-0.017631011,
0.010937136,
-0.017134175,
-0.003954557,
-0.0039142724,
0.0073317075,
0.02249196,
0.007043005,
0.008244814,
-0.008607371,
0.02584897,
-0.020048058,
0.006270893,
-0.0107558565,
-0.028789708,
-0.0054517826,
0.016892469,
0.021444574,
-0.0025009718,
0.0018346054,
0.016865613,
-0.010641718,
-0.0004385093,
0.017053606,
0.0061970386,
-0.0019588147,
-0.052396197,
-0.024694158,
0.0063178907,
-0.030374218,
0.014139722,
-0.01729531,
-0.0015165288,
-0.015925651,
-0.00090555317,
0.00045109808,
0.00093744474,
0.019363228,
0.02297537,
-0.013495176,
-0.003743065,
0.041250926,
-0.011198982,
-0.026815787,
-0.01853069,
-0.016019646,
-0.0061970386,
0.017899573,
-0.03015937,
-0.020101769,
0.03724937,
0.030669633,
0.0039109155,
-0.017402735,
0.018758966,
-0.01990035,
-0.0054819956,
0.029729672,
0.04643415,
0.023499062,
0.011386975,
0.015898794,
0.024868723,
-0.028816566,
0.01886639,
-0.0039277007,
-0.01784586,
-0.013052051,
-0.021323722,
-0.0029927734,
-0.021202868,
-0.012595498,
-0.00171711,
-0.005737128,
-0.035772286,
0.020732887,
-0.0036121416,
-0.021417717,
0.025634121,
-0.017067034,
-0.014005441,
0.0031656595,
0.0065025263,
0.051429376,
0.013193046,
-0.002991095,
-0.020880597,
-0.00024485184,
0.000025282474,
0.03507403,
-0.026654651,
0.021498285,
0.020356903,
-0.0035416444,
0.010708858,
-0.01695961,
-0.0007977093,
-0.006660306,
0.011225838,
0.00817096,
0.014381426,
-0.020558324,
0.029085126,
-0.002811495,
0.007989681,
0.0046024593,
-0.031958725,
0.0072578536,
0.02598325,
-0.023391638,
-0.0076472666,
-0.01415315,
0.025674405,
0.02556698,
0.017631011,
0.01818156,
-0.0072645675,
-0.0035450014,
-0.029487967,
0.0015425456,
-0.011527969,
-0.0042902576,
0.02768861,
0.00033633033,
0.033516377,
-0.011715962,
-0.008835647,
0.0016684334,
-0.03432206,
0.017939856,
-0.012246368,
0.0038404183,
0.017523587,
0.010809569,
-0.004122407,
-0.015885366,
-0.022679953,
-0.016999893,
0.046031307,
-0.01627478,
0.019403512,
-0.009439909,
0.022666525,
-0.0017959998,
0.005962048,
0.005253719,
-0.0026537157,
-0.0265338,
0.010151595,
0.012333651,
-0.0046192445,
0.00022512942,
0.008976642,
0.040364675,
-0.013542174,
-0.010588006,
-0.03303297,
-0.015925651,
0.004968373,
-0.01029259,
-0.02981024,
-0.6320845,
-0.0038941305,
0.012467931,
-0.023029082,
0.024398742,
0.009782325,
0.0050422275,
-0.0061735394,
0.006321248,
0.01558995,
-0.020491183,
0.023767624,
0.019376656,
-0.025620693,
-0.015012545,
-0.027258912,
-0.020531466,
0.015710803,
0.019134952,
-0.0190141,
-0.027500618,
-0.018087564,
0.0073585636,
0.012454503,
0.020813456,
0.025795257,
-0.0009458373,
-0.01134669,
-0.017913,
0.008802078,
0.001277342,
0.001277342,
0.008023252,
0.019551221,
0.03741051,
-0.023713911,
-0.011601823,
0.02030319,
-0.02421075,
0.0073317075,
0.00004665718,
-0.0020309906,
0.023015654,
-0.023445351,
-0.005579349,
0.00902364,
0.025029859,
-0.006680448,
0.0020477755,
-0.022572529,
0.0046259584,
-0.0030028445,
-0.014743984,
0.033408955,
0.033838652,
0.013978586,
0.022277111,
-0.0053779283,
-0.014099438,
0.019027527,
0.0038471322,
-0.0014384784,
-0.023364782,
-0.02235768,
0.005250362,
0.028494293,
-0.026466658,
-0.019578077,
0.022787377,
0.008842362,
0.0076338383,
0.027097777,
0.007190713,
-0.017631011,
0.033194106,
0.04232517,
-0.012521643,
0.03636312,
-0.012971483,
0.0148245515,
-0.013495176,
0.018006995,
-0.035772286,
0.015563094,
0.027849747,
-0.009627902,
-0.01784586,
0.004914661,
0.021874271,
-0.007378706,
-0.004575603,
0.02474787,
-0.034563765,
-0.0009122672,
-0.025378987,
0.032012437,
0.00074315787,
0.00044270555,
0.018745538,
-0.0046226014,
-0.021310292,
0.0057673412,
0.00039759575,
-0.013790593,
-0.009601045,
0.01682533,
-0.042352024,
0.005354429,
0.019698929,
-0.019954061,
-0.0070900028,
-0.00018526493,
-0.007439132,
0.0018446764,
-0.029568534,
-0.028628573,
0.026345806,
0.009265345,
-0.017617583,
-0.01353546,
0.002412011,
-0.012091947,
0.0048307357,
0.0043506837,
0.0054752817,
0.003417435,
-0.0018967101,
-0.0118301,
-0.01343475,
-0.014475423,
-0.009728612,
0.027930316,
0.041680623,
-0.008157532,
-0.0028484222,
0.0148245515,
0.046595287,
-0.007962826,
-0.012253082,
-0.0451182,
-0.032898687,
-0.0050959396,
-0.006301106,
-0.0141800055,
0.010279162,
-0.0020024558,
0.0030599136,
0.017872715,
-0.0030380932,
0.019108094,
0.006811371,
-0.009815894,
-0.01709389,
0.01859783,
0.024774726,
-0.0042701154,
-0.011353404,
-0.03459062,
-0.010688717,
0.007781547,
0.010232164,
0.018852962,
-0.0092720585,
-0.002069596,
-0.05586063,
-0.02919255,
0.012870773,
0.020907452,
0.0068516554,
-0.03426835,
0.008802078,
0.00096178305,
-0.010735715,
0.007841973,
-0.0025949678,
0.0050623696,
-0.013166189,
-0.0029827026,
-0.0065092403,
0.009339199,
-0.006784515,
-0.016892469,
-0.011695819,
0.0011917382,
0.04648786,
-0.0016340241,
0.012461217,
0.03083077,
-0.011198982,
0.027957171,
-0.0021065231,
0.013871161,
-0.03187816,
0.015066257,
-0.034107212,
-0.028789708,
0.019108094,
-0.025378987,
0.0057203434,
0.036551114,
0.026224954,
0.0065058833,
0.012588784,
0.009540619,
0.021511713,
0.0012152373,
-0.0062272516,
-0.007016149,
0.0036255696,
0.005267147,
0.012239655,
0.002801424,
-0.025217852,
-0.022371108,
0.005136224,
0.018973814,
-0.023203647,
0.0042634015,
0.019054383,
-0.040982366,
0.007022863,
-0.013924873,
0.018356126,
0.028897133,
-0.042432595,
0.029380543,
0.00069657934,
-0.00044648218,
-0.016059931,
-0.03348952,
-0.0155362375,
0.021981696,
0.002645323,
-0.015321389,
0.02152514,
0.019551221,
0.0028786352,
0.0015727587,
0.011131842,
0.03241528,
0.004014983,
0.0035047175,
0.025956394,
-0.0123067945,
0.025472984,
-0.0068818685,
0.016261352,
-0.0046192445,
-0.016368777,
0.01654334,
-0.002422082,
0.01784586,
-0.025647549,
-0.016838757,
0.006062758,
-0.001600454,
0.032039292,
0.007170571,
0.020477755,
0.02194141,
0.03287183,
0.008157532,
0.0112728365,
-0.033113535,
-0.00878865,
0.028977701,
0.004572246,
0.0218877,
-0.012226227,
-0.022679953,
-0.013817449,
0.0018144634,
0.01022545,
-0.010453726,
0.02892399,
-0.00068524946,
0.01268278,
0.022008551,
0.012494788,
0.012978197,
-0.022465104,
-0.016167356,
0.031421605,
0.019645216,
0.01069543,
-0.0057908404,
-0.010064313,
-0.004122407,
-0.0069960067,
0.011326549,
-0.0033889005,
0.02351249,
0.0026167885,
-0.014555991,
-0.0093996255,
-0.01627478,
0.012978197,
-0.014851408,
0.018826107,
-0.007157143,
0.007009435,
0.00820453,
-0.038511608,
-0.00627425,
0.025714688,
0.0073854197,
-0.015818227,
-0.018141277,
0.009372769,
0.006717375,
0.026654651,
0.024277888,
-0.005945263,
-0.03357009,
-0.014851408,
0.023687055,
-0.013387752,
0.0028433867,
0.030938195,
-0.016973037,
-0.027178345,
-0.033113535,
0.00803668,
-0.014381426,
0.026627796,
-0.0026470015,
0.0035517155,
0.02421075,
-0.002422082,
-0.014663415,
-0.009137779,
-0.020424042,
0.018651541,
-0.0054182126,
0.0032764408,
0.01428743,
0.014878264,
0.00018369133,
0.019766068,
-0.0027174987,
-0.0018933531,
-0.028118307,
-0.0072779953,
0.0013159475,
0.00261511,
0.021243153,
0.003370437,
0.022572529,
0.009453338,
-0.009466765,
0.02324393,
0.032039292,
0.02658751,
-0.018906675,
0.014999116,
0.016489629,
-0.0024959361,
0.00015106541,
-0.043130852,
-0.025244707,
-0.0038504894,
0.030857626,
0.0049717305,
0.0042029754,
0.005962048,
0.029299974,
-0.018423265,
-0.002019241,
0.0033116895,
-0.027433477,
-0.007103431,
-0.0025630763,
-0.014099438,
-0.008902788,
0.017281882,
-0.00082036905,
0.015979363,
-0.017241599,
0.023633344,
0.01206509,
0.00096178305,
0.0090773525,
-0.012461217,
-0.021995123,
-0.0036188557,
-0.011031131,
0.037168805,
-0.0107558565,
0.004434609,
-0.035450015,
-0.022384536,
-0.009426481,
-0.019188663,
0.021511713,
0.01131312,
-0.01669105,
-0.030481642,
0.01565709,
0.030589066,
0.0066099507,
0.006720732,
-0.006247394,
-0.012024806,
0.039558996,
-0.014032298,
-0.02037033,
0.0002633154,
-0.008231386,
0.020343475,
-0.0041459063,
0.0064051733,
0.014421711,
0.0012093625,
-0.03630941,
0.0118569555,
-0.0272052,
0.014999116,
-0.025929537,
0.009956889,
-0.0012303438,
0.010326159,
0.016194211,
0.007130287,
-0.0013621064,
-0.011487685,
-0.018369554,
-0.007828545,
-0.018006995,
-0.005958691,
-0.010816283,
-0.0103060175,
0.00634139,
0.018020425,
-0.014126293,
0.023029082,
-0.004609173,
0.0039914837,
0.010668575,
0.028870277,
0.036658537,
-0.016006218,
0.0490929,
-0.009198205,
-0.006982579,
-0.008607371,
0.03171702,
0.03171702,
-0.0066737337,
-0.01196438,
0.020880597,
0.0077748327,
0.0050724405,
-0.0043271845,
0.025660977,
0.0076674083,
0.013092335,
-0.013871161,
-0.0548401,
-0.027527474,
-0.014193434,
0.0012135587,
0.026077246,
-0.015495953,
-0.020061485,
-0.017913,
-0.0022995512,
0.0034241492,
0.009298915,
0.049227178,
-0.02666808,
-0.012018092,
-0.01271635,
-0.050381992,
0.007828545,
-0.013938301,
-0.0025194352,
-0.033731226,
0.00035143687,
-0.012333651,
-0.033194106,
-0.014623132,
-0.033059824,
-0.004092194,
0.018678399,
0.04095551,
0.0023515848,
0.0020209195,
0.008815506,
0.0021770203,
0.019296087,
-0.027742323,
0.016422488,
-0.03233471,
0.028521148,
-0.000713784,
-0.01975264,
0.01069543,
-0.01886639,
0.007888971,
0.011642107,
0.0031320893,
0.0042969715,
-0.009325771,
-0.028521148,
0.0057002013,
0.020437472,
-0.017496731,
0.01818156,
-0.02529842,
-0.013716739,
0.03663168,
0.010520866,
0.006244037,
-0.012770062,
0.004129121,
-0.029407399,
0.025754973,
-0.0022810877,
0.0096614715,
-0.01094385,
-0.019081239,
0.007499558,
-0.008264956,
-0.012373935,
0.0070631467,
0.018960387,
0.00425333,
-0.011695819,
-0.025593836,
-0.0031035547,
-0.012998339,
0.002395226,
-0.014274002,
-0.012407505,
-0.018423265,
0.015509382,
-0.0014728877,
-0.037652213,
-0.009493621,
0.008634227,
-0.003048164,
0.02180713,
-0.042137176,
-0.012326937,
0.0011581681,
-0.018033853,
0.024371885,
-0.012051662,
0.023955615,
0.004464822,
-0.013139334,
-0.015495953,
-0.0048005227,
-0.007700979,
-0.014757412,
0.014757412,
-0.0074122758,
-0.0016482914,
-0.031797588,
-0.0029474539,
0.028145164,
-0.006371603,
-0.011836814,
0.026856072,
0.022545673,
0.0010188522,
-0.02611753,
-0.0013125906,
-0.013387752,
0.025969822,
0.019430367,
-0.027715467,
-0.012387363,
0.00964133,
-0.015898794,
0.017913,
0.00011508246,
0.0268695,
0.009198205,
0.01203152,
-0.005680059,
-0.0043305415,
-0.043936532,
0.012273225,
-0.0066133076,
0.030427929,
-0.021914555,
0.018920103,
-0.01667762,
0.034886036,
0.00820453,
0.004196261,
-0.011373547,
0.03918301,
0.0034610762,
-0.015912222,
0.024761299,
-0.021431146,
0.03732994,
-0.034671187,
-0.0065898085,
-0.024291318,
-0.021323722,
-0.0024640446,
0.022988798,
0.008580515,
-0.026856072,
0.0007234354,
-0.01213223,
-0.025956394,
-0.037840206,
-0.0060795434,
0.024358457,
-0.023552775,
-0.015375101,
-0.016395632,
0.0035718575,
-0.0056968443,
-0.013078907,
0.0042130463,
-0.007197427,
0.021458002,
-0.0006323766,
0.002113237,
-0.014072582,
0.0103060175,
-0.010212021,
0.011924096,
-0.000045267167,
-0.011977808,
0.03397293,
-0.0035550725,
-0.039371002,
-0.020598607,
0.004793809,
0.006690519,
0.0022693381,
-0.0040888367,
-0.0026520372,
0.019940633,
0.00042067518,
0.009332485,
0.00018883175,
0.008580515,
-0.0049885153,
0.0012093625,
0.005646489,
-0.015160252,
0.005616276,
-0.0145022785,
-0.012454503,
0.018221844,
-0.005619633,
-0.022250256,
-0.035611153,
0.0032025867,
-0.021122301,
-0.005267147,
-0.000918142,
0.0068583693,
-0.02645323,
0.024103325,
0.0031623025,
-0.0076808366,
-0.0125015015,
0.008164246,
0.004135835,
-0.00850666,
-0.00047669528,
-0.0029054913,
0.002361656,
-0.02447931,
-0.038592175,
-0.008016538,
-0.01709389,
0.013119191,
0.0030834128,
-0.012635781,
-0.008828933,
0.005643132,
-0.038645886,
-0.001084314,
-0.009621188,
0.013347467,
0.02488215,
0.027634898,
-0.018544117,
-0.015898794,
-0.017939856,
0.0090773525,
-0.008614085,
0.015509382,
0.034134068,
-0.0046930984,
0.019242376,
0.0054920665,
-0.03002509,
-0.01428743,
0.013542174,
-0.01593908,
-0.0059016217,
0.011319835,
-0.00041731817,
0.0072645675,
-0.0070900028,
-0.0054551396,
0.025822112,
0.017201314,
0.02658751,
-0.026198098,
-0.012582069,
0.004484964,
-0.014139722,
-0.014475423,
-0.006361532,
0.004468179,
0.015845083,
0.009963603,
-0.026842644,
-0.020195765,
0.03246899,
-0.010097883,
0.001028084,
0.027742323,
-0.012904342,
0.021551998,
-0.00058286067,
0.00037073967,
-0.028950846,
0.00016585723,
-0.026775504,
0.03109933,
0.023754196,
-0.0086879395,
-0.0175773,
0.009332485,
-0.0020377045,
-0.024304746,
0.022008551,
-0.014260574,
-0.00016155606,
-0.016919326,
0.012588784,
0.044124525,
0.0110781295,
-0.0020158838,
0.011125128,
0.00041354154,
-0.0095943315,
-0.028709142,
-0.00850666,
-0.010091169,
-0.010930421,
0.019672073,
-0.010272448,
0.010977419,
0.0018295699,
-0.017738435,
-0.016919326,
-0.004639386,
0.16994523,
0.0015450633,
-0.0033939362,
0.009681614,
0.0010641719,
-0.0017305381,
0.013844305,
0.00087450084,
0.0050422275,
0.0131460475,
0.015670517,
0.010104597,
-0.010541008,
-0.004484964,
-0.0013587493,
-0.017899573,
-0.025056714,
-0.027876602,
0.0063749603,
-0.0014166578,
0.002621824,
-0.014435139,
0.01134669,
-0.0072914236,
0.021202868,
0.0014997438,
0.0013478391,
0.0057706987,
0.041761193,
0.030239938,
-0.012441075,
0.01042687,
0.010782713,
0.015683945,
0.0021770203,
0.011299692,
0.0049213753,
-0.0013276971,
0.0072511393,
0.0000120249115,
0.009621188,
-0.006059401,
-0.042352024,
0.0095943315,
-0.018060708,
0.025217852,
-0.0064689564,
0.0035718575,
-0.017604155,
0.013240043,
-0.046998125,
0.011682391,
0.033113535,
0.010789427,
0.006710661,
-0.015133397,
0.01695961,
0.00022366073,
0.0024707585,
0.02105516,
-0.021766847,
0.014515707,
-0.024707586,
0.028655428,
-0.013790593,
0.027634898,
-0.00970847,
-0.027218629,
-0.012474646,
-0.008258242,
0.009903177,
-0.009789038,
-0.016516484,
0.017805576,
-0.039290432,
0.004142549,
0.016785044,
0.019497508,
-0.00915792,
0.020961164,
-0.011749531,
0.0034644334,
-0.024855295,
-0.011205696,
-0.019309515,
-0.024371885,
0.00018127849,
0.030320505,
-0.025822112,
-0.015818227,
-0.005169794,
-0.017483303,
-0.020518038,
-0.01579137,
0.001866497,
-0.015401958,
0.0035718575,
-0.0047770236,
-0.008694653,
-0.0014166578,
-0.021431146,
0.07261882,
-0.0021484857,
0.008795364,
-0.017510159,
0.007989681,
-0.023901904,
0.025352132,
-0.006381674,
0.0114004025,
-0.0042600445,
0.014596275,
0.012118802,
-0.01261564,
-0.0075062723,
0.016570196,
0.0072175693,
-0.011823386,
0.013689883,
-0.02660094,
-0.0050321566,
-0.0016986466,
-0.0034224708,
0.012414219,
-0.026748648,
-0.002558041,
-0.013139334,
0.012085232,
0.012864059,
-0.027715467,
-0.007432418,
-0.015240821,
-0.0042466163,
-0.00012913994,
0.0012185943,
0.0076405522,
0.00046704386,
0.0024271174,
0.01203152,
0.0076472666,
-0.0021820557,
0.0021703064,
0.008654369,
-0.0008220476,
0.026063818,
-0.015643662,
0.025043286,
0.004112336,
-0.024868723,
0.0011522933,
-0.0012622353,
-0.02481501,
0.0037665642,
0.007137001,
0.022706809,
-0.017738435,
-0.0340535,
-0.052691612,
0.0027023922,
0.00315391,
-0.025190996,
-0.018409837,
0.031233612,
-0.027984027,
-0.010245591,
-0.001620596,
-0.16876356,
0.026238382,
0.016838757,
-0.012622354,
0.022250256,
0.007398848,
0.009903177,
0.009789038,
0.00019355255,
0.015240821,
0.025553552,
-0.0014116223,
-0.025969822,
-0.039075583,
0.0046125306,
0.040310964,
-0.016180784,
-0.0031052334,
0.006096328,
0.013710025,
0.013052051,
-0.014300859,
0.02556698,
-0.037356798,
-0.015321389,
0.019927206,
-0.021122301,
0.016999893,
-0.00228948,
-0.008694653,
-0.021498285,
0.018745538,
0.025956394,
-0.008318668,
0.023445351,
-0.00083253824,
-0.0030565567,
-0.02857486,
-0.0066401637,
0.011621965,
0.019188663,
0.021780275,
-0.011574967,
-0.0072108554,
-0.028789708,
0.0047367397,
0.004035125,
-0.010715573,
0.02570126,
-0.007110145,
0.013025195,
-0.0082381,
-0.007888971,
0.0064857416,
0.0018916746,
0.0068952963,
-0.0152139645,
0.014596275,
0.016046504,
-0.011259408,
0.018450122,
-0.010675289,
0.01722817,
0.035584297,
-0.014112866,
-0.0114004025,
-0.009124351,
-0.029299974,
-0.018799251,
-0.002262624,
-0.028279444,
0.0008044233,
0.0009643008,
-0.01687904,
0.024586733,
0.007083289,
0.00016124133,
0.002432153,
-0.009580904,
0.045735892,
0.011286264,
0.009413053,
-0.02426446,
-0.018020425,
-0.008540231,
0.0032814762,
0.00048592704,
0.007472702,
0.0015526167,
0.008741652,
0.032173574,
-0.030723346,
0.004370826,
-0.029219406,
0.0071839993,
-0.004061981,
0.01620764,
0.005643132,
0.00909078,
-0.025378987,
0.022599384,
-0.015549665,
-0.016288208,
0.026238382,
0.017523587,
0.027930316,
-0.012199371,
0.012944627,
0.024049612,
-0.0018581045,
0.009990458,
-0.008828933,
0.000003268494,
0.041385207,
-0.033999786,
0.024036184,
0.015321389,
-0.013374324,
0.023754196,
0.0002152682,
0.034778614,
0.0072511393,
0.003806848,
0.0017943213,
0.0065025263,
-0.055914342,
-0.13159475,
-0.054168697,
0.005908336,
0.010769285,
0.0027930315,
0.009446624,
0.007009435,
0.0046897414,
0.014784267,
0.027822891,
-0.000610556,
0.00329994,
0.009762182,
0.0021199512,
0.012098661,
0.006297749,
0.01701332,
-0.0027443548,
-0.027044065,
0.03808191,
-0.015133397,
-0.014112866,
-0.00025681118,
0.0043473267,
-0.013454892,
0.010916993,
0.008345525,
0.0111452695,
-0.0025194352,
-0.014072582,
0.03246899,
-0.009513764,
0.019309515,
-0.028386869,
-0.027097777,
0.0003291967,
0.014488851,
-0.019470653,
0.032844976,
-0.010353016,
0.010896851,
-0.004122407,
0.027796034,
0.0093996255,
-0.010003887,
-0.024009328,
-0.03684653,
-0.00091478496,
-0.023069365,
-0.010896851,
-0.008097106,
-0.010285876,
-0.020826884,
-0.0017557157,
0.046461005,
0.0052167918,
0.019134952,
0.019000672,
-0.02194141,
-0.005327573,
-0.0043506837,
-0.0039646276,
-0.027634898,
0.009292201,
0.016113643,
0.0034375773,
-0.01859783,
-0.027232056,
0.010198593,
-0.02570126,
-0.008567087,
0.0021014877,
0.007056433,
0.0011615251,
-0.03821619,
0.013488462,
-0.013360896,
-0.013387752,
0.01319976,
-0.0016860578,
-0.020101769,
-0.032012437,
0.011756245,
-0.00024653034,
0.014743984,
0.015845083,
-0.0019218876,
0.010849853,
0.0050053005,
-0.026372662,
-0.02857486,
0.022653097,
-0.0027695324,
-0.013817449,
-0.012333651,
0.01059472,
0.016999893,
-0.0058646947,
0.0207866,
-0.025660977,
0.0073854197,
-0.04033782,
-0.04997915,
-0.008412665,
0.0012890914,
-0.023566203,
0.0028299587,
0.0038102053,
0.033274673,
0.005468568,
0.018141277,
-0.00024002614,
-0.040257253,
0.031797588,
-0.008909502,
0.0025932894,
-0.031126188,
-0.033892363,
0.030938195,
-0.009426481,
0.013125905,
0.023364782,
0.00683487,
0.0039981976,
-0.017872715,
0.0190141,
-0.013481748,
0.0049784444,
-0.035664864,
0.0029491324,
-0.015348245,
-0.012387363,
-0.0056632743,
-0.03719566,
-0.0024237605,
-0.015066257,
-0.021350577,
-0.001317626,
-0.009251917,
0.03741051,
0.008486519,
0.028145164,
-0.025795257,
-0.014958832,
-0.0054551396,
-0.000828342,
0.014623132,
-0.010191879,
-0.0053947135,
0.013710025,
-0.0017573942,
-0.020746315,
0.027957171,
0.0008098784,
0.006385031,
-0.007828545,
-0.029702816,
0.0023398353,
0.0033200819,
0.014206862,
-0.013508604,
-0.0075935544,
0.044285662,
0.0023969044,
0.013804021,
0.020195765,
0.0015945793,
-0.006009046,
-0.010118025,
-0.020249479,
0.027822891,
0.0043003284,
-0.03357009,
-0.024868723,
0.000786799,
0.011299692,
0.01742959,
-0.005653203,
-0.012978197,
-0.01148097,
-0.0063783173,
0.019497508,
0.020732887,
-0.011118414,
-0.013804021,
0.025472984,
0.03786706,
0.025956394,
-0.0054014274,
0.018168133,
0.0079762535,
0.010836425,
-0.012333651,
-0.009560762,
0.007982967,
-0.00079057564,
0.0050187283,
0.024318174,
0.0033049753,
0.007432418,
0.016261352,
0.025325276,
0.016033076,
0.022814233,
-0.0065864515,
-0.019806353,
0.003343581,
0.012427648,
-0.0369271,
-0.034375772,
-0.038431037,
0.013884589,
0.012890914,
0.0069020106,
-0.004142549,
0.0024371885,
-0.007996395,
0.014851408,
-0.028145164,
-0.021632565,
-0.00027716305,
0.031502172,
0.0068583693,
0.010970705,
0.011628679,
-0.009037068,
0.007855401,
-0.02515071,
0.052825894,
-0.0043070423,
0.01552281,
-0.026292095,
0.0107558565,
-0.006096328,
-0.027232056,
-0.014381426,
0.00024023595,
-0.023311071,
-0.0027443548,
0.023149934,
-0.020289762,
0.07734549,
0.0054752817,
0.017402735,
0.010400014,
0.016637336,
0.02249196,
-0.0117898155,
0.010406728,
0.0035483586,
-0.024989575,
0.039048728,
-0.0021652707,
0.03198558,
-0.031609595,
-0.018973814,
0.0076271244,
0.00312034,
0.010003887,
0.0068650832,
-0.02946111,
0.008063535,
-0.017886143,
-0.005267147,
0.017416162,
-0.018382981,
0.0063783173,
0.03402664,
-0.016704477,
0.004864306,
-0.02598325,
0.004834093,
0.017416162,
-0.04305028,
0.009345913,
0.0025110426,
-0.007989681,
0.0013629457,
-0.014931976,
0.004518534,
0.029434254,
0.001024727,
0.025526697,
-0.01722817,
0.0012681101,
-0.021820558,
-0.014435139,
-0.030642778,
0.0068818685,
-0.021296864
] |
BACKGROUND Patients considered for arterial surgery, have been shown to have a high incidence of coexistent cardiac, vascular and other diseases, affecting operative risk and survival. We developed a systematic workup strategy for detecting these coexistent diseases in our vascular surgical patients, mainly based on non-invasive diagnostic techniques. METHODS We evaluated 200 consecutive patients, admitted to the department of vascular surgery in an academic teaching hospital, in order to establish the total incidence of relevant concomitant disorders, the extent to which this screening yielded previously unknown diagnostic information, and the impact on short-term (one year) survival. RESULTS Coronary artery disease was present in 46 | [
-0.021029506,
0.002783024,
0.038447883,
-0.024799947,
-0.03188944,
0.024255622,
-0.018400816,
0.023936994,
-0.033933975,
0.015586262,
-0.01727234,
0.013023955,
-0.009592056,
0.025224784,
-0.011882202,
0.00015724002,
0.04758191,
-0.003594532,
0.015891615,
-0.03388087,
-0.024760118,
0.027348978,
-0.011683058,
0.013508536,
-0.0067310347,
0.022290744,
0.023060765,
-0.033163954,
0.0011824118,
-0.02489288,
0.01363466,
-0.00863617,
-0.015002109,
-0.014736585,
0.00015298749,
0.004002775,
0.0017093112,
0.0028228527,
0.0070961304,
-0.00583821,
0.012718602,
-0.021932287,
-0.005635748,
-0.017803388,
-0.024906157,
0.004633395,
-0.0071027684,
-0.037810627,
-0.021560553,
0.032393936,
0.044873565,
0.006744311,
-0.016104033,
-0.002321676,
0.013701041,
-0.00007680491,
-0.007003197,
0.040784497,
-0.009293342,
-0.03244704,
-0.0028029382,
-0.0047495617,
-0.017152853,
0.02052501,
-0.040386207,
-0.0057817865,
-0.0054598385,
0.02234385,
0.0128181735,
0.026857758,
0.046652578,
0.02506547,
-0.005964334,
0.0046566282,
0.025609795,
-0.010149657,
-0.016210243,
-0.029765246,
-0.013428879,
0.001569911,
0.0028045978,
-0.035288148,
0.010853296,
0.017949427,
0.033960525,
-0.016077481,
-0.0017607564,
0.022542993,
-0.007660369,
-0.007454588,
0.037279576,
0.022463335,
-0.0039463514,
-0.0025938381,
-0.0058548055,
0.0051511666,
-0.006465511,
0.022888174,
0.018122017,
-0.023034211,
0.00293736,
0.0027465145,
-0.021972116,
-0.01832116,
-0.004855771,
0.0034816843,
-0.005572686,
0.0016918861,
0.016621806,
-0.0037073796,
0.008822037,
0.050077837,
-0.000950908,
-0.0024710333,
0.028331418,
-0.018228227,
0.008377284,
0.012612392,
-0.002192233,
-0.013030593,
0.030933553,
-0.004387785,
0.019290322,
-0.020856915,
0.011988411,
-0.0050184047,
-0.012453078,
0.008516684,
0.0054432433,
-0.012625669,
-0.005589281,
0.012924383,
0.005844848,
0.013966565,
-0.0041654087,
-0.0098243905,
-0.016581977,
0.026021358,
-0.023724575,
-0.051458564,
-0.015387119,
0.0013458751,
-0.022569545,
-0.04314766,
0.001835435,
0.029499723,
0.027242769,
0.028278312,
-0.0023233355,
-0.008138312,
-0.017750284,
-0.004573652,
-0.009658437,
-0.018161846,
0.0020080258,
-0.01731217,
0.009791199,
0.013886908,
0.008523323,
0.0027465145,
-0.01125822,
0.015851786,
-0.0057651913,
-0.009777923,
0.0065152966,
-0.004185323,
-0.004849133,
0.0042848946,
-0.017086472,
-0.010939592,
-0.0262205,
0.031252183,
-0.021879183,
0.008795484,
0.022768687,
0.011716249,
-0.016289901,
0.003972904,
-0.04991852,
-0.0490954,
-0.018812379,
0.0014736585,
0.029207647,
0.023631642,
-0.028596941,
0.018706169,
0.019967409,
-0.00072106376,
0.008450303,
-0.013979842,
0.011271496,
0.030269742,
-0.0038866084,
-0.0035049175,
-0.63980675,
-0.017259063,
-0.003943032,
-0.010753725,
0.026140843,
0.013873632,
0.012599116,
0.013727593,
-0.015440224,
0.0015616134,
-0.014524166,
0.013833803,
0.01401967,
-0.017843217,
-0.010375353,
-0.02010017,
0.008755656,
-0.0035679794,
0.010939592,
-0.00092352583,
0.0053469907,
0.027534844,
-0.0072488068,
0.012917745,
0.008822037,
0.019131009,
0.022317298,
-0.013588194,
-0.0002422907,
0.013269565,
0.003796994,
0.021414515,
0.009372999,
0.021308305,
0.04192625,
-0.015612815,
-0.014059499,
0.022715583,
0.016489044,
0.014909176,
-0.008198055,
0.001863647,
0.025742557,
0.001601442,
-0.0075475215,
0.016369559,
0.017989255,
-0.014391404,
-0.0019366661,
-0.006349344,
0.007421397,
-0.020910019,
-0.023830784,
-0.010381991,
0.019077903,
-0.028543836,
0.013156717,
-0.033376373,
-0.0027730667,
0.011364429,
-0.0020113448,
0.017949427,
0.009923962,
-0.024348555,
-0.010800191,
0.04535151,
-0.009061009,
0.0050715096,
0.004138856,
-0.004796028,
0.028331418,
0.018347712,
0.01506849,
-0.013243012,
0.03377466,
0.020445352,
0.017683903,
0.04086415,
-0.02880936,
-0.008961437,
-0.007832959,
0.006794097,
-0.006007482,
0.01115201,
0.020047067,
0.0049188333,
-0.030986657,
0.009080923,
0.013335946,
-0.01999396,
0.0066181873,
0.005831572,
-0.027216217,
-0.027986236,
0.0010164593,
0.013209822,
-0.021002952,
0.0017176088,
0.020817086,
-0.019170837,
-0.026233777,
0.0040260083,
5.4453176e-7,
0.01010319,
-0.00051196356,
0.010222676,
-0.02793313,
-0.008689275,
0.022330573,
-0.027853474,
0.006744311,
-0.019861199,
0.01167642,
-0.007832959,
0.009718181,
-0.021202097,
-0.012486269,
-0.0035414272,
-0.010554581,
-0.01936998,
-0.0018287969,
-0.014271918,
0.0013259607,
-0.017219234,
0.028995227,
-0.0029307217,
-0.0033240293,
-0.025782386,
-0.00033833573,
-0.020020515,
0.0044043805,
-0.03013698,
0.019038076,
-0.006060587,
0.008483494,
-0.02422907,
-0.006080501,
0.004002775,
-0.016874054,
-0.012931022,
-0.00157323,
0.009585419,
0.013050508,
0.018931866,
-0.01528091,
0.0032642863,
-0.008178141,
0.0016927158,
-0.0023017616,
0.0039762226,
-0.01605093,
-0.022423506,
-0.010262505,
0.009200408,
0.006541849,
0.0055992384,
0.012320316,
0.00075715844,
0.004039285,
-0.0010571176,
0.013621384,
-0.003209522,
-0.015586262,
0.0009733116,
0.0023034213,
-0.023485603,
-0.020750705,
-0.0041620894,
-0.029393513,
-0.016966987,
0.022503164,
-0.024932709,
0.008822037,
0.010999334,
-0.0051909955,
0.010388629,
-0.029818352,
-0.012386697,
-0.0052739717,
-0.0016055908,
-0.0030402504,
-0.00478939,
-0.012147726,
0.011543659,
0.02926075,
0.019887751,
0.01887876,
0.0007862001,
-0.011888839,
-0.000709862,
0.006359301,
0.014935728,
-0.03873996,
-0.0005555261,
-0.010767001,
0.009359723,
0.0047329664,
0.0046665855,
-0.0009948855,
0.029446619,
0.05597247,
-0.012453078,
0.024202518,
0.014285194,
0.014192261,
-0.0021822758,
0.010654152,
0.004892281,
0.029101437,
-0.0044773994,
-0.009691628,
-0.01594472,
0.00038376523,
-0.016608529,
0.00008048698,
0.030668028,
0.012380059,
-0.014524166,
-0.0038700132,
0.0011143712,
-0.0031282052,
-0.017856494,
0.025198232,
-0.003168034,
-0.009970428,
0.007175788,
0.014630375,
0.019847924,
0.0039695846,
-0.014218813,
-0.017869769,
0.026087739,
0.0104284575,
0.020538285,
0.0003070122,
0.027110007,
0.0056523434,
-0.0065219346,
0.014922452,
0.033217058,
0.010401905,
0.012645584,
0.023445774,
0.00020640346,
0.005439924,
-0.00056631304,
0.03300464,
0.02129503,
-0.017245788,
0.007076216,
0.009738095,
-0.0077533023,
0.011855649,
0.014749861,
-0.017073197,
-0.015599539,
0.02803934,
0.0047628377,
0.03377466,
0.013754146,
0.03985516,
0.026034635,
-0.009817752,
0.0025822215,
0.0004157111,
-0.014909176,
0.0011649868,
-0.021002952,
0.00017829526,
-0.000580419,
-0.0034451745,
-0.02045863,
0.006541849,
-0.04073139,
0.017750284,
0.012931022,
-0.013282841,
-0.00199309,
0.030216638,
-0.0076736454,
-0.0023714618,
-0.03895238,
0.0016985242,
0.02542393,
0.0006156839,
0.0010264164,
0.02450787,
-0.009406189,
0.003153098,
0.0320222,
0.0013774061,
-0.007945808,
-0.006555125,
-0.0062464536,
0.0019433042,
-0.008569789,
0.034279156,
0.009691628,
0.016940435,
-0.02202522,
-0.015241081,
0.004168728,
-0.009738095,
-0.016196968,
0.020856915,
0.013833803,
-0.010143019,
-0.0014587227,
0.0030153575,
-0.0037472083,
0.0058017005,
-0.0024444808,
-0.0040923897,
-0.0035049175,
0.011324601,
0.034730546,
-0.023220079,
-0.0026983882,
0.013807251,
0.006757587,
0.004961981,
-0.011809182,
0.0008853568,
-0.02936696,
0.037359234,
0.0026104334,
0.00050325104,
0.01836099,
-0.010893124,
-0.010561219,
-0.02422907,
-0.024574252,
0.036775082,
0.018440645,
0.025291167,
0.005901272,
0.030774238,
0.005589281,
0.015413672,
0.030694582,
-0.0023897165,
0.0057817865,
0.015201252,
-0.010886487,
-0.0007264572,
0.00905437,
0.04304145,
0.045006327,
0.023764404,
-0.020737428,
0.013847079,
0.008483494,
-0.0017873088,
0.014178985,
-0.03688129,
0.021839354,
-0.0048126234,
0.03666887,
-0.014325023,
-0.0031630553,
0.0033124126,
-0.000027408098,
-0.000965014,
0.0017391825,
0.0364299,
0.018281331,
0.0052175475,
0.012313678,
0.005088105,
-0.014670204,
0.0030950147,
-0.0013060465,
0.020896744,
-0.010747086,
0.036350243,
0.0034949605,
-0.0023764402,
-0.03852754,
0.020617943,
-0.011085629,
0.011371068,
0.0037870368,
-0.035022624,
-0.0036609129,
-0.0036476366,
-0.01269205,
0.009910685,
-0.0063924915,
-0.01440468,
-0.00555941,
-0.045510825,
-0.016608529,
-0.011795906,
0.0009359723,
0.0092999805,
0.0008351561,
-0.003972904,
0.0051412093,
0.013481984,
-0.0028610218,
0.01643594,
-0.006794097,
0.011291411,
0.011351153,
-0.010050085,
0.0081449505,
0.016369559,
-0.008901694,
0.019250493,
-0.0010562879,
-0.025623072,
-0.01594472,
0.006568401,
0.024109583,
0.009273428,
-0.008616256,
0.013475345,
-0.009611971,
0.017139578,
0.020020515,
0.007766579,
0.010640876,
-0.024348555,
-0.024295451,
0.0038866084,
-0.028065892,
-0.0013085357,
-0.011231667,
-0.013103612,
-0.015493329,
-0.022144707,
-0.015825234,
0.008012189,
-0.013316032,
0.02230402,
-0.00398618,
-0.0024909475,
-0.0070430255,
0.022277469,
0.02045863,
-0.008456941,
0.029712142,
0.027853474,
-0.0018271374,
0.006870435,
0.019808095,
0.023936994,
-0.0024112903,
-0.038660303,
0.02590187,
0.014696756,
-0.019396532,
-0.04601532,
0.00060655654,
-0.0025175,
0.03356224,
-0.009087561,
-0.015161424,
-0.02636654,
-0.012074706,
0.0116100395,
-0.0004489016,
-0.041129675,
-0.0049254713,
-0.0055328575,
0.019330151,
-0.008257798,
-0.0122273825,
0.046280842,
-0.028065892,
-0.0011724547,
-0.004497314,
-0.034226052,
-0.0049719377,
-0.0062962393,
0.01349526,
-0.00065509765,
-0.00092767464,
-0.038554095,
-0.04787399,
-0.014325023,
-0.00720234,
0.01101261,
0.04115623,
0.019569123,
-0.0023863974,
0.02688431,
0.01451089,
-0.00028232674,
0.0071027684,
-0.01915756,
0.0058647627,
0.005512943,
0.04460804,
0.0055195815,
-0.004391104,
0.0051578046,
-0.019940857,
0.042563505,
0.0087357415,
0.0027913216,
-0.018998247,
-0.008994628,
-0.03287188,
0.012260573,
-0.033084296,
0.000286683,
0.020923296,
-0.026140843,
0.007912617,
0.02328646,
-0.004311447,
-0.00394967,
-0.027242769,
0.020777257,
0.0067907777,
0.024029927,
0.012884554,
0.017949427,
0.0055560907,
-0.007607264,
-0.018692894,
0.018507026,
-0.0003642658,
0.0071492353,
0.008908332,
0.006611549,
-0.023751127,
-0.041474856,
0.01909118,
-0.03706716,
-0.007905979,
0.019104457,
-0.017046645,
0.00061900297,
-0.0072222543,
-0.007408121,
-0.012758431,
0.011855649,
-0.0036874653,
-0.015705748,
0.011809182,
-0.028570388,
0.007793131,
-0.020047067,
-0.012931022,
-0.0052573765,
-0.016316453,
0.048856426,
0.0042284704,
-0.0116100395,
-0.021480896,
-0.0032227982,
0.007016473,
0.007189064,
0.012386697,
0.008297627,
-0.0074479496,
-0.012406612,
-0.0008737401,
0.03597851,
-0.03411984,
-0.046413604,
0.03852754,
0.0026884312,
0.005964334,
-0.010939592,
-0.03345603,
-0.03223462,
0.012499545,
-0.008125036,
0.0021673401,
0.014776413,
-0.029712142,
0.010056724,
0.0036111271,
-0.04274937,
0.015002109,
-0.00027402912,
-0.021772973,
-0.0104948385,
0.0024776713,
0.00042359385,
0.007607264,
0.027906578,
0.006810692,
-0.0065816776,
0.009399552,
-0.0008870163,
0.013236375,
-0.007255445,
0.0019516018,
-0.019980686,
0.041873142,
-0.0017391825,
0.00069285184,
0.008649446,
-0.0046566282,
-0.013276203,
0.008237883,
-0.01192203,
-0.03982861,
-0.027800368,
-0.0035015985,
0.030375952,
0.022317298,
-0.0031829695,
-0.0006911923,
-0.017816665,
-0.029101437,
-0.008503408,
-0.009200408,
0.0040857513,
-0.014723309,
-0.03457123,
-0.010707257,
-0.015041938,
0.009426104,
-0.003275903,
0.005101381,
-0.01101261,
0.014802966,
-0.00068870303,
0.018095464,
0.01401967,
0.012472993,
-0.009386275,
0.038500987,
-0.022914726,
-0.014922452,
0.009007904,
0.01244644,
-0.033057746,
-0.017803388,
0.01244644,
0.0016711421,
-0.019144284,
-0.0019350066,
0.035288148,
-0.005947739,
0.0027880026,
-0.0027465145,
-0.009067646,
0.018613236,
-0.026937416,
-0.0036609129,
0.024640633,
-0.02495926,
0.005745277,
0.011357792,
0.020710876,
-0.0065849964,
-0.009253513,
-0.03796994,
-0.02290145,
0.04028,
0.004049242,
-0.009432742,
-0.031623915,
-0.0019665374,
-0.011450725,
-0.0004991022,
-0.011278134,
-0.020498456,
0.005237462,
-0.019077903,
-0.014776413,
0.0016918861,
-0.018653065,
0.013428879,
0.010448372,
0.003926437,
-0.009605332,
0.0104948385,
-0.0375451,
0.0011600083,
0.013714317,
0.014178985,
-0.017843217,
-0.010395267,
-0.050396465,
-0.00968499,
-0.014364852,
0.029871456,
0.01247963,
0.01688733,
0.017644074,
0.016754568,
-0.011729525,
0.009572142,
-0.01905135,
-0.018480474,
0.023060765,
0.002125852,
0.024428213,
-0.01528091,
-0.039085142,
-0.034465022,
-0.013780698,
-0.0048590903,
0.007534245,
0.0033124126,
-0.007421397,
0.011689696,
-0.005964334,
0.009399552,
-0.0052806097,
0.0043479563,
-0.023857336,
-0.021441067,
-0.00082187995,
0.006658016,
0.0026668573,
-0.012433164,
0.0021972116,
0.0047993474,
-0.00020173605,
0.0033787936,
-0.0055229003,
-0.021520725,
-0.0003509896,
-0.0206976,
-0.005844848,
-0.0052606952,
0.011483915,
0.0027149834,
0.016834226,
0.016343005,
-0.015652644,
0.0056689386,
0.010435095,
-0.0016553765,
0.013594831,
-0.0024395022,
-0.0098243905,
-0.009386275,
-0.0018653065,
-0.0050150855,
-0.0008467728,
-0.017418379,
-0.012492907,
-0.01755114,
0.031756677,
-0.0077333883,
0.013953289,
0.000007506759,
0.016024377,
-0.027906578,
0.005775148,
-0.022808516,
0.002185595,
-0.009286704,
-0.010866572,
-0.00202794,
-0.0039563086,
0.004593566,
-0.0013815549,
-0.025729282,
-0.023127146,
0.007600626,
0.17811354,
0.0024328642,
0.0012106238,
0.024295451,
0.0012247297,
-0.0072156163,
0.03478365,
0.011902116,
-0.02653913,
0.05042302,
0.0045072706,
-0.024494594,
0.0047694757,
0.0027299193,
0.027720712,
-0.0028560432,
-0.0027249407,
-0.03666887,
0.011410897,
0.0040193703,
0.0012338571,
-0.012798259,
0.037784074,
-0.011065715,
0.028092446,
0.011483915,
0.016568702,
0.0020959806,
0.04405044,
-0.012313678,
0.006419044,
-0.012592479,
-0.002356526,
0.0036210844,
0.0063991295,
-0.00734174,
0.0059344624,
0.0035015985,
0.0012595798,
-0.024839776,
-0.037465446,
-0.0023399307,
-0.019662056,
-0.003528151,
-0.009923962,
0.026074462,
0.0006953411,
-0.020259485,
-0.025344271,
-0.0035613414,
-0.035951957,
-0.005970972,
0.016143862,
-0.0031248862,
-0.012486269,
-0.0016080801,
0.028437626,
0.009831028,
0.0023714618,
0.016515596,
0.016196968,
-0.003411984,
-0.008397198,
0.036801632,
-0.014431233,
0.028543836,
-0.019144284,
-0.011835734,
-0.003793675,
-0.0027896622,
0.011769353,
-0.048803322,
-0.018613236,
0.0067111207,
0.01101261,
-0.022065049,
0.020445352,
0.009731457,
-0.012333592,
0.0018022446,
0.013475345,
-0.014086051,
-0.00849677,
0.014524166,
-0.023512155,
-0.025782386,
0.0029904647,
0.024839776,
-0.008271074,
-0.022888174,
-0.01401967,
-0.007919255,
-0.029420065,
-0.01678112,
0.013966565,
0.015665919,
0.016581977,
-0.0065783584,
0.01059441,
0.0050316807,
0.004978576,
0.08756983,
0.004132218,
-0.0044176565,
-0.020763982,
0.0056523434,
-0.033296715,
0.019423084,
0.010607686,
0.0036277224,
-0.004052561,
-0.0032958174,
-0.01699354,
-0.009446018,
0.00044309327,
0.048298825,
0.027880026,
-0.027773816,
-0.003411984,
-0.0066314633,
-0.0009915663,
-0.031199077,
0.015334014,
0.036137823,
-0.001290281,
-0.023857336,
-0.012718602,
-0.0015823575,
-0.010003619,
-0.024255622,
0.0029771884,
-0.0047030947,
-0.012864641,
0.011855649,
0.005957696,
0.0016512277,
-0.021494173,
-0.012758431,
-0.016621806,
0.015015385,
0.009446018,
-0.02653913,
0.0077001974,
0.0044110185,
0.023644917,
-0.0030219958,
0.011231667,
-0.0015367204,
-0.006136925,
-0.0008027954,
-0.0007223084,
-0.0007322656,
-0.0063028773,
-0.007998913,
0.03775752,
-0.028862465,
0.004855771,
-0.0253841,
-0.0030153575,
-0.009346447,
-0.010328886,
0.016263349,
0.033402927,
-0.013243012,
-0.0061933487,
0.0019433042,
-0.16643047,
0.009220323,
0.0072355303,
-0.018029083,
0.029154541,
0.00065094884,
0.027348978,
0.008456941,
-0.016940435,
-0.022317298,
0.03510228,
0.007919255,
-0.0034451745,
-0.016608529,
0.0063692583,
0.007846236,
-0.028304864,
0.01789632,
0.018268054,
0.0040757945,
0.0157323,
0.00097082235,
-0.001391512,
-0.035580225,
0.0021208734,
-0.032367382,
-0.018998247,
0.024096308,
-0.009087561,
-0.007879427,
-0.013900184,
0.010461648,
0.026193948,
-0.009366361,
-0.021520725,
-0.0013218119,
-0.011205115,
-0.016728016,
0.005041638,
0.0033522411,
0.017564416,
0.020644495,
0.020286039,
-0.0072819972,
-0.016661635,
0.0061302865,
0.024733566,
-0.0122141065,
0.025915148,
-0.005831572,
0.010747086,
-0.007122683,
-0.0006650548,
-0.0010156295,
0.0012570905,
0.01909118,
-0.015373843,
0.00075674354,
0.013661212,
-0.0065650824,
0.0071027684,
-0.005094743,
-0.00076296675,
0.035606775,
-0.011550296,
-0.036987502,
0.009173856,
-0.0064621917,
-0.0066181873,
0.02412286,
-0.022330573,
0.008430389,
0.0042284704,
-0.027348978,
0.041766934,
0.005101381,
-0.026180672,
0.0028228527,
-0.0070297495,
-0.019675333,
-0.0016752909,
0.004185323,
-0.020432075,
-0.019462913,
0.0075010546,
0.026393091,
0.01810874,
-0.023140421,
0.017856494,
-0.010760362,
0.030057322,
-0.053688966,
-0.00018690404,
0.0104948385,
0.0016213562,
0.028889017,
0.022184534,
-0.018135292,
-0.001898497,
-0.017006816,
0.014391404,
-0.0035181937,
-0.002653581,
-0.003591213,
0.0059875674,
0.01789632,
0.013674489,
0.005821615,
0.031703573,
-0.0029572742,
-0.02031259,
0.0015533157,
0.0060572675,
0.007998913,
-0.00065219344,
0.019608952,
0.00050781475,
-0.0010056724,
-0.0009923961,
-0.012326954,
0.048644006,
0.00842375,
0.006541849,
0.027747264,
0.021772973,
0.0067609064,
-0.1290447,
-0.004205237,
0.014285194,
0.023525432,
-0.0016545468,
0.00877557,
-0.008642808,
0.0057353196,
-0.023366116,
0.03289843,
-0.012419888,
-0.034279156,
0.0026900906,
-0.01650232,
0.032632906,
0.0003126131,
-0.012977488,
-0.027800368,
-0.025145128,
0.022503164,
-0.013043869,
-0.02489288,
0.0242689,
-0.040147237,
-0.03279222,
-0.0005812488,
-0.015161424,
0.0075740735,
0.005386819,
0.008483494,
-0.0017225873,
0.024348555,
-0.0012114535,
0.011842373,
-0.012034878,
-0.0007986466,
0.005496348,
-0.026393091,
0.03510228,
-0.016303178,
0.008450303,
0.01915756,
0.008430389,
0.012718602,
0.010946229,
-0.007142597,
-0.039164796,
-0.0010703938,
-0.0048259,
-0.025410652,
0.0029522956,
-0.02300766,
0.0065650824,
0.004520547,
0.012492907,
-0.014218813,
-0.0059975246,
0.011384344,
-0.020485181,
-0.0071027684,
-0.002125852,
0.0035082365,
-0.014178985,
0.022038497,
0.024640633,
-0.031544257,
-0.0028577026,
-0.019914305,
0.014285194,
-0.005632429,
-0.019582398,
0.0058050198,
-0.021042781,
-0.00032837858,
-0.03863375,
0.0030535266,
-0.015825234,
0.006750949,
0.015320738,
-0.025078747,
-0.004387785,
-0.014006394,
0.03743889,
-0.0030734409,
-0.0072819972,
0.02245006,
-0.02230402,
-0.013223098,
-0.019316874,
-0.018745998,
0.02146762,
0.008928247,
0.005363586,
-0.004862409,
0.011497191,
0.009983704,
0.015865061,
-0.026910864,
-0.0013973203,
0.040386207,
-0.011915392,
-0.009399552,
-0.039669294,
0.015705748,
0.0063924915,
0.0040260083,
-0.009983704,
0.005356948,
0.021427792,
0.004321404,
0.019914305,
-0.0070828544,
-0.041023467,
0.004898919,
-0.016303178,
0.00555941,
-0.011464001,
-0.0046499902,
0.0218128,
0.0087091895,
0.034066737,
0.019184113,
0.0057485956,
0.026300158,
0.0026203906,
0.026167396,
0.020830363,
0.0033854316,
-0.019635504,
0.03454468,
-0.01727234,
0.0038766512,
0.004128899,
-0.0253841,
-0.020445352,
0.010269143,
0.0020959806,
-0.022396954,
0.005230824,
0.018241502,
0.015028661,
0.03510228,
-0.028304864,
-0.016289901,
0.00071898935,
-0.026632063,
-0.01755114,
0.015134871,
-0.018228227,
0.037120264,
-0.019954132,
-0.023047488,
-0.003202884,
0.0012637286,
-0.00042214175,
-0.040811047,
-0.029552827,
0.014338299,
0.02318025,
-0.00615352,
-0.0032310958,
-0.04227143,
0.03167702,
0.004586928,
0.015466777,
0.0024378428,
0.022768687,
-0.030641476,
-0.0053835004,
-0.02031259,
0.013123526,
-0.013979842,
-0.019223941,
-0.019715162,
-0.02202522,
0.01615714,
0.010853296,
0.0028792764,
-0.008516684,
0.037491996,
-0.01720596,
0.029659037,
0.027428634,
0.010123105,
-0.0044906754,
0.02506547,
0.021029506,
-0.0038866084,
-0.025450481,
0.041209333,
-0.013754146,
0.012977488,
-0.020631218,
0.012698688,
-0.011975135,
-0.006000844,
-0.0040160515,
0.022622649,
-0.010375353,
-0.0028411073,
0.021626934,
0.011517106,
-0.017418379,
0.0023548664,
-0.02758795,
-0.021587105,
-0.017418379,
-0.0033987078,
-0.010342162,
-0.032632906,
-0.02045863,
0.011809182,
0.023220079,
0.026021358,
0.004450847,
0.007056302,
0.014922452,
0.009983704,
-0.02384406,
0.008025465,
-0.021626934,
-0.0011948582,
0.0015425289,
0.011510468,
0.024680462,
0.0032842006,
0.001793947,
0.0098376665,
0.0038202275,
-0.017763559,
0.015081766,
-0.010089914,
0.011729525,
0.009791199,
-0.009625247,
-0.0056623006,
0.00038169083,
-0.045218747,
0.017604245,
0.013727593,
-0.012466354,
0.060220856,
-0.0017723731,
-0.0193036,
-0.0034949605,
-0.032712564,
0.008058655,
0.003793675,
-0.013090336,
-0.017750284,
-0.026406368,
-0.002950636,
-0.008729103,
0.021095887,
-0.04028,
-0.01894514,
0.034836758,
0.0012537714,
0.0040226895,
0.010016895,
-0.029951114,
-0.017511312,
-0.017577693,
0.016382834,
0.0006360131,
-0.019595675,
-0.021759696,
0.009034456,
-0.01583851,
-0.021826077,
-0.037571654,
-0.001111882,
-0.0022187855,
-0.02947317,
-0.013754146,
-0.00199309,
0.013608108,
-0.012526098,
-0.027561396,
-0.0036841463,
0.00622322,
-0.013588194,
0.031915992,
-0.02902178,
-0.028596941,
-0.029632485,
-0.039483428,
-0.018958418,
-0.007534245,
-0.007607264
] |
OBJECTIVE To assess if family care givers of patients with lung cancer experience the patterns of social, psychological, and spiritual wellbeing and distress typical of the patient, from diagnosis to death. DESIGN Secondary analysis of serial qualitative interviews carried out every three months for up to a year or to bereavement. SETTING South east Scotland. PARTICIPANTS 19 patients with lung cancer and their 19 family carers, totalling 88 interviews (42 with patients and 46 with carers). RESULTS Carers followed clear patterns of social, psychological, and spiritual wellbeing and distress that mirrored the experiences of those for whom they were caring, with | [
-0.006469026,
-0.001200778,
0.033252314,
-0.044705886,
-0.0055156616,
0.026021253,
-0.0041004587,
0.012621364,
-0.031114664,
-0.01601917,
-0.04518092,
0.027261619,
0.009810751,
0.026878953,
-0.0018671438,
0.02480728,
0.036999796,
-0.020782696,
-0.0013112891,
-0.023171056,
-0.020729914,
0.0054298914,
-0.021046603,
0.008075561,
-0.0038332527,
0.0031388467,
0.009823947,
-0.026364334,
0.0004193651,
-0.026681023,
0.00085110083,
-0.010035072,
-0.014528094,
-0.010529899,
-0.014660047,
-0.010087854,
-0.003803563,
-0.008623169,
0.041750126,
-0.026364334,
0.00041194272,
-0.0109389555,
-0.0077192867,
0.0038926317,
-0.0138287395,
0.016507398,
-0.0010919162,
-0.025453854,
-0.012126538,
0.00093192246,
-0.0039849994,
0.008722134,
-0.015742067,
-0.00901903,
0.023804434,
-0.011156678,
-0.006478923,
0.02298632,
0.0233294,
-0.002025488,
-0.020611156,
-0.002927721,
-0.018077645,
0.022577265,
-0.013723177,
0.0010234653,
0.0037870689,
0.028370028,
0.009606224,
0.004502917,
0.04478506,
0.025097579,
-0.029346485,
0.02677339,
0.01840753,
0.003909126,
-0.013512051,
0.00021050726,
-0.0123970425,
0.025519831,
-0.006927565,
0.00030534892,
-0.015623309,
0.0135780275,
0.002708348,
0.016942846,
-0.022801585,
0.009949303,
0.009408293,
0.0046084803,
0.0049746516,
0.004140045,
0.016296271,
0.009982292,
-0.0046612616,
0.02295993,
0.0030481287,
0.011941803,
0.0033153347,
-0.053810686,
-0.019990973,
-0.0015083948,
-0.025440658,
-0.001852299,
-0.015253838,
-0.020004168,
-0.00022782617,
0.0067263357,
0.019529136,
0.0019001322,
-0.0324342,
0.02330301,
-0.012878673,
0.0035693455,
0.030797975,
-0.02586291,
-0.011103897,
-0.008860686,
-0.017510245,
-0.015267034,
0.01587402,
-0.025044797,
0.027683869,
-0.021350095,
0.015201057,
-0.021046603,
-0.0378443,
-0.00981735,
-0.015478159,
-0.0087023415,
-0.01766859,
0.011684493,
0.039454132,
0.009896521,
-0.020558374,
0.0034769778,
-0.002088166,
-0.0053309263,
-0.026707413,
-0.029452048,
0.0035660467,
0.02990069,
-0.0005863689,
-0.018908953,
-0.016520593,
0.013802349,
0.03436072,
0.007303633,
-0.015359402,
-0.0067758183,
0.009639212,
-0.014580875,
-0.004387458,
-0.009942706,
0.00415324,
-0.003109157,
0.004219217,
0.011394195,
-0.038213767,
-0.0041268496,
-0.00901903,
0.00500764,
-0.0028815372,
0.016652547,
0.0007109001,
0.01530662,
0.02438503,
-0.012304675,
-0.019252034,
-0.00009102738,
-0.008662756,
0.027525526,
-0.018090842,
-0.002523613,
-0.008082159,
0.0042752973,
-0.0072244606,
0.00973158,
-0.030138208,
-0.02045281,
-0.041143138,
0.034677412,
0.02771026,
0.022709219,
-0.030956319,
-0.03969165,
0.0078116544,
0.001550455,
0.0026968021,
-0.0066735544,
0.008002987,
0.026641436,
0.0074355863,
-0.035178836,
-0.6456227,
-0.011585528,
0.030164598,
-0.004773422,
0.01493715,
0.019845825,
0.015860826,
-0.003249358,
-0.051593866,
0.02623238,
0.014158623,
0.029821519,
0.017853325,
-0.008220711,
-0.0146336565,
-0.025242727,
-0.026496287,
0.0033582198,
0.03462463,
-0.019819435,
-0.00765331,
0.039929166,
0.005195674,
0.016005974,
-0.014369749,
0.042541847,
0.01550455,
-0.02426627,
0.023751652,
0.022893954,
-0.02074311,
0.0196347,
0.0013195362,
0.022141818,
0.044125292,
-0.016494203,
-0.020584764,
0.026337942,
0.008504411,
0.03348983,
-0.0064921184,
-0.0031784328,
0.026628241,
-0.0031470938,
-0.036630325,
0.009889924,
0.002747934,
0.011743872,
0.019476354,
0.0039849994,
0.011156678,
0.013327315,
-0.017563026,
-0.00022452734,
0.028607545,
-0.00884749,
0.032882843,
-0.042172376,
0.008814502,
0.022009864,
0.005225363,
0.012350859,
-0.012159526,
-0.026786584,
0.0112028625,
0.039902776,
0.0012337663,
0.0031075077,
0.003316984,
0.001852299,
0.024714913,
0.042832144,
0.009408293,
0.0023405273,
0.038160987,
0.012924857,
0.016045561,
0.013894716,
-0.0047899163,
0.0054562823,
-0.003312036,
-0.011882423,
-0.032249466,
0.010879576,
0.03462463,
-0.009045421,
0.001852299,
-0.0011174822,
0.0040575736,
0.017022017,
-0.009447879,
0.010622267,
-0.023606503,
0.003132249,
-0.0075147585,
0.03747483,
-0.012476215,
-0.009315926,
0.018895758,
-0.03966526,
-0.010998335,
-0.0013145879,
0.0146336565,
-0.0077390797,
0.0037771724,
0.0029128762,
-0.028871452,
-0.0031289503,
0.022498092,
-0.025810128,
0.006581187,
0.023144664,
0.028660327,
-0.022933539,
0.014053061,
-0.026496287,
0.013426281,
0.0030002955,
0.0028600947,
-0.03887354,
0.008557192,
0.009949303,
0.021020211,
-0.0018621954,
0.022234185,
0.031061882,
-0.022643242,
-0.019964583,
0.0018325059,
-0.0019727065,
0.011222656,
-0.021943888,
0.008794709,
-0.0012733524,
0.013498856,
-0.004555699,
0.012001182,
-0.0028551465,
-0.0063238773,
-0.028211685,
-0.012370652,
0.008887077,
0.014726024,
0.0013187116,
-0.00082512246,
-0.004984548,
-0.016995626,
-0.015372597,
-0.0044600326,
0.0023438262,
-0.0056344196,
-0.0039058272,
0.008893674,
0.016032364,
0.009830545,
0.0015685987,
0.004783319,
-0.014119037,
0.003316984,
-0.006119349,
0.025401073,
0.00514949,
-0.016995626,
-0.02654907,
-0.0041202516,
-0.01826238,
-0.0030563758,
0.013070006,
0.013472465,
-0.03969165,
-0.029372877,
-0.016533788,
-0.015253838,
0.021917496,
0.011070909,
0.0022399127,
0.0043082857,
-0.0010770714,
0.027763043,
-0.005419995,
0.008986042,
0.008484618,
0.0012890219,
0.0011397494,
0.009698591,
0.016573375,
0.030085426,
0.0151482755,
0.011037921,
0.014607266,
-0.016599765,
0.032091122,
-0.0026968021,
0.038134597,
0.0015900411,
0.027578307,
-0.025849715,
-0.012469617,
-0.007877631,
0.004595285,
0.004304987,
-0.006125947,
0.035258006,
0.019054104,
0.015530941,
-0.0030481287,
0.00048657897,
-0.0018143622,
0.024741303,
-0.021442464,
0.01257518,
-0.002037034,
-0.0133141205,
-0.00012504667,
-0.012502606,
0.03098271,
0.012251894,
-0.0013962343,
-0.015926803,
-0.004555699,
-0.0023537227,
0.000028297867,
0.027551915,
0.0017038512,
-0.010562887,
0.009032225,
-0.0284492,
0.0060137864,
0.009005834,
-0.0024873258,
-0.003952011,
0.013775958,
0.0065844855,
0.032091122,
0.0068615885,
0.012891869,
0.008062366,
-0.03137857,
0.03934857,
0.0063865553,
-0.010318773,
0.017022017,
0.0010828445,
0.004720641,
-0.0049680537,
0.0053474205,
0.02042642,
-0.0038167585,
0.00017308604,
-0.0041202516,
0.0036716096,
0.014132232,
-0.026126817,
0.002990399,
0.02224738,
-0.00554865,
0.0068351976,
0.007178277,
0.034413505,
0.006986944,
0.015689285,
0.0044633313,
0.018935345,
-0.005024134,
0.0010160429,
-0.00039771647,
-0.01912008,
0.0035495523,
-0.019568723,
-0.008504411,
0.0058653383,
-0.011526149,
0.0018061151,
-0.046711583,
0.029821519,
0.02202306,
0.0014160273,
-0.006620773,
0.0055321557,
0.013762763,
-0.019647894,
-0.005914821,
0.029742345,
0.026443506,
-0.010991736,
-0.022352943,
-0.0038827353,
0.033014797,
-0.0024081536,
0.005934614,
0.020136122,
0.01038475,
0.009117995,
0.004123551,
0.013340511,
0.01914647,
0.0056377184,
-0.008141538,
0.010905967,
0.0046414686,
0.003234513,
-0.017681785,
-0.0135780275,
-0.02426627,
0.012159526,
0.01718036,
-0.044626713,
-0.03317314,
-0.03707897,
-0.02771026,
-0.012410238,
-0.01806445,
-0.00975797,
-0.02170637,
0.015860826,
-0.016678937,
0.014171819,
0.016494203,
0.032117512,
-0.017087994,
-0.02534829,
-0.028554764,
-0.0115921255,
0.0088276975,
0.08128343,
0.0067956117,
0.011776861,
0.010226405,
0.031193836,
0.0024658833,
-0.00013906675,
-0.0238968,
0.00057111174,
-0.00847802,
0.0011240799,
-0.0062743947,
0.01402667,
0.011889021,
0.021244533,
0.03354261,
0.0049152724,
-0.02623238,
-0.006703244,
-0.004842698,
-0.006228211,
-0.02802695,
0.029399266,
0.027604697,
-0.003579242,
-0.007165082,
0.034492675,
0.021468854,
0.00077110395,
-0.0101340385,
-0.0024229984,
0.03391208,
-0.005090111,
0.03676228,
-0.013201959,
0.0013574729,
0.055578865,
0.013789154,
0.022775196,
-0.0073762075,
0.004493021,
-0.013386695,
0.016269881,
-0.0019957984,
0.03177443,
-0.018737415,
0.0016527191,
0.032962013,
0.0075213565,
-0.0016939546,
0.028581154,
-0.027525526,
0.0028271063,
-0.027393572,
0.029742345,
-0.0014300473,
0.0010209911,
-0.005423294,
0.0037936666,
-0.0057267873,
-0.010338566,
-0.02441142,
-0.0065086125,
-0.007178277,
-0.019555526,
-0.027921386,
-0.024002364,
-0.0041070567,
-0.0059313155,
-0.022484897,
0.012410238,
-0.014185014,
0.00089810934,
0.031668868,
0.013644004,
-0.0046975487,
0.024107926,
-0.010371555,
0.011070909,
-0.0077390797,
-0.013413086,
0.008629767,
-0.00037833577,
-0.019212447,
-0.014475312,
0.0026737102,
0.008609974,
-0.016573375,
-0.00554865,
0.002606084,
-0.010378152,
0.013670395,
-0.01587402,
-0.002107959,
0.0019199252,
0.045682345,
-0.0022151715,
0.02094104,
-0.016335858,
-0.01892215,
0.019700676,
-0.023553722,
-0.016296271,
-0.025308704,
0.0059280163,
-0.004763526,
-0.01402667,
0.00028411264,
0.0035528513,
-0.017008822,
0.034096815,
-0.03319953,
0.009302731,
0.0014853029,
0.0038860342,
-0.001989201,
-0.016903259,
0.02950483,
0.017945692,
-0.011598723,
-0.01029898,
-0.016942846,
0.016177515,
0.0008354314,
-0.027288008,
-0.015082299,
-0.015333011,
-0.0060665677,
0.0032114212,
-0.0061688316,
0.0072772424,
0.015583723,
0.009414891,
-0.03393847,
0.0013195362,
0.002526912,
-0.005053824,
0.009513856,
0.0024823775,
-0.008959651,
-0.023778042,
0.0006725511,
0.0051824786,
-0.009830545,
0.039401352,
-0.027419962,
-0.021574417,
0.0038167585,
0.00415324,
0.006452532,
-0.040351417,
-0.009652407,
-0.017391488,
0.018856172,
-0.003061324,
-0.025335096,
-0.008088757,
0.0013178868,
0.0035264606,
0.0026440206,
0.030956319,
0.0025450555,
0.0014292226,
0.00008819244,
-0.0022580563,
0.002088166,
0.0050307317,
0.0030563758,
0.0014226249,
0.022273771,
0.013644004,
-0.004591986,
0.010582681,
-0.017167166,
0.015280229,
0.02005695,
-0.018473508,
-0.031193836,
-0.008946455,
-0.042040423,
-0.038081814,
-0.0015570527,
-0.025625393,
0.0021359993,
-0.032618936,
0.006469026,
0.019608308,
-0.002147545,
-0.017391488,
0.00204858,
0.010965345,
-0.026997712,
0.0050142375,
0.0058422466,
-0.0050505246,
-0.021178557,
-0.017193558,
-0.02387041,
-0.02113897,
-0.0133735,
0.007831448,
0.016744915,
0.01840753,
-0.012251894,
0.008801307,
0.0035891384,
-0.02606084,
-0.004341274,
0.002253108,
-0.03454546,
-0.006769221,
-0.020281272,
-0.0015026218,
-0.026403919,
-0.012990834,
0.011460172,
0.010430934,
0.027525526,
-0.00355615,
-0.024015559,
-0.005047226,
0.009889924,
0.0324342,
0.00041709715,
0.023804434,
0.005647615,
-0.04127509,
-0.020861868,
-0.0031734845,
0.023316205,
-0.014910759,
0.015953192,
0.023632893,
-0.018684633,
0.02113897,
0.011321621,
0.028686717,
-0.0443892,
-0.014950345,
0.0025021706,
-0.0036782073,
-0.0020898154,
-0.014660047,
-0.01806445,
-0.007824849,
0.03174804,
-0.009164179,
-0.01493715,
-0.018856172,
-0.03024377,
-0.0041037574,
0.0042489064,
-0.01966109,
0.01656018,
0.0081613315,
-0.01055629,
-0.010279187,
0.00054265925,
-0.017853325,
0.0021046603,
-0.0001128822,
0.022234185,
-0.0043115844,
0.0028518476,
0.0041631367,
-0.0009847039,
-0.014699633,
0.008669353,
-0.02298632,
0.040588934,
-0.008339468,
-0.014145428,
0.025546221,
0.00046183768,
0.006723037,
0.012608169,
0.008794709,
-0.0088276975,
-0.039190225,
-0.0025384577,
0.018842977,
0.023830824,
0.0013154127,
0.008755122,
-0.017048407,
-0.0040806658,
0.032909233,
-0.02241892,
0.0016411731,
-0.0031371973,
-0.01263456,
-0.017259534,
0.011367804,
0.025559416,
-0.0006111102,
-0.016626157,
-0.0074355863,
0.028132511,
-0.022141818,
0.020848673,
0.006947358,
0.0067956117,
-0.014039866,
0.016626157,
-0.006188625,
-0.019806238,
0.01917286,
-0.01047052,
-0.024596155,
-0.038767975,
0.011882423,
0.008887077,
-0.010061463,
-0.024596155,
0.0007764646,
0.0196347,
-0.0018242588,
-0.013010627,
-0.028475592,
0.024253076,
-0.018499898,
0.018447116,
0.01661296,
-0.001778075,
0.01047052,
-0.0040212865,
0.033014797,
0.00992951,
-0.020835476,
-0.014673242,
-0.014660047,
0.0005294639,
-0.023171056,
0.02241892,
-0.02347455,
0.00014659223,
-0.026377529,
0.033357874,
0.0045523997,
-0.0036386212,
0.011618516,
-0.009348914,
0.017325511,
-0.004654664,
-0.026008058,
0.005271547,
-0.014607266,
-0.019291619,
-0.023857215,
-0.012251894,
-0.012779708,
0.04119592,
0.019001322,
-0.0040047923,
-0.03681506,
-0.008062366,
-0.046790753,
-0.0006832723,
-0.0013137632,
0.03491493,
-0.005980798,
0.0017335407,
0.0031207032,
0.014343359,
0.0031338986,
0.01766859,
0.0033565701,
-0.039401352,
0.021376487,
-0.015161471,
0.004486423,
-0.008431836,
-0.016810892,
-0.002253108,
0.0050769155,
0.0047239396,
-0.03787069,
0.0016716875,
-0.009645809,
-0.026760194,
-0.013155776,
0.0068549905,
-0.034466285,
0.0055288565,
-0.011473367,
-0.00765331,
-0.0020667235,
0.0040905625,
-0.0003570995,
0.012482813,
-0.007468575,
0.032645326,
0.010734427,
-0.0012939702,
-0.012007779,
-0.023171056,
0.0014638605,
-0.0054463856,
0.018565875,
0.013960693,
0.001556228,
0.017523441,
0.014673242,
0.00486579,
-0.006967151,
-0.011697688,
0.0012238699,
-0.020875063,
0.01948955,
-0.021152165,
0.0000096323565,
-0.0020337352,
-0.021864714,
-0.015623309,
0.00048039365,
-0.02660185,
-0.013208558,
-0.018697828,
0.013907911,
0.019753456,
-0.013815545,
-0.0069077723,
-0.021864714,
-0.024002364,
-0.03533718,
-0.019608308,
0.0014119038,
-0.038609628,
0.01985902,
-0.0075807357,
0.0012032521,
0.017932497,
-0.009896521,
-0.016071951,
0.004196125,
0.016810892,
0.19930275,
-0.019304814,
-0.022009864,
0.00668675,
-0.018803392,
-0.016942846,
0.028317247,
0.009243351,
-0.027182447,
0.02606084,
-0.003021738,
-0.014185014,
-0.0075807357,
0.012806099,
0.0037111957,
-0.013723177,
-0.009480868,
0.00006674998,
-0.021627199,
-0.008689146,
-0.0051758806,
-0.0057894653,
0.011856033,
0.0019017815,
0.029821519,
0.016731719,
-0.026351139,
-0.0076005287,
0.02409473,
0.0028287556,
-0.009533649,
0.00037771725,
-0.01855268,
0.004648066,
0.006561394,
-0.010912565,
0.023712065,
-0.017747762,
0.013221753,
0.0072706444,
-0.0030464793,
0.012799501,
-0.018117232,
-0.007673103,
0.019040907,
0.031536914,
-0.011697688,
-0.0025879403,
-0.010853185,
-0.009969096,
-0.023197446,
-0.008867283,
0.010444129,
0.010569485,
-0.022366138,
0.005977499,
0.028475592,
0.0065218075,
-0.025783738,
0.009500661,
0.0072244606,
-0.000708426,
-0.019924996,
0.021165362,
-0.0076862983,
0.004420446,
-0.002935968,
-0.0067197382,
0.005558546,
-0.016890064,
0.019449964,
-0.021957083,
-0.014673242,
0.013604418,
-0.004347872,
-0.012766513,
0.009995487,
0.0027231928,
0.022089036,
0.03792347,
-0.0005339998,
-0.0029326691,
-0.026892148,
0.013419683,
-0.011631711,
-0.021152165,
0.0034868745,
0.01897493,
-0.004855893,
-0.0041004587,
0.0017203453,
0.016164318,
-0.0028980314,
0.009507258,
0.027683869,
0.01823599,
0.019951388,
0.0002643196,
-0.011611919,
-0.0074157934,
-0.00577627,
0.046130985,
-0.015649699,
0.021798737,
-0.0023487743,
0.005255053,
-0.0052682483,
0.009593029,
0.0073762075,
0.0022498092,
0.014923954,
-0.037237313,
0.019001322,
-0.0040839645,
0.005650914,
0.020835476,
-0.021376487,
-0.026628241,
0.013353706,
-0.022643242,
0.0033285301,
-0.0117306765,
0.022669632,
0.017391488,
-0.0109389555,
-0.004512814,
-0.024107926,
-0.03644559,
-0.008379055,
-0.008075561,
0.010483715,
-0.043914165,
0.004367665,
0.00061688316,
0.0029656577,
-0.008616571,
0.0027347389,
-0.015187861,
0.00049688783,
-0.01283249,
0.016507398,
-0.020677133,
-0.019700676,
-0.00044451875,
-0.0123838475,
-0.020663938,
0.022115426,
0.00007963607,
-0.024028754,
-0.023171056,
-0.024490591,
0.0067197382,
-0.013089799,
-0.009117995,
0.025546221,
-0.030270161,
-0.010582681,
-0.004839399,
0.003206473,
0.0054562823,
-0.0036386212,
0.000249681,
0.030085426,
0.008379055,
0.004964755,
0.026694218,
-0.16647269,
0.024569765,
0.01838114,
-0.023936387,
0.023685675,
-0.0023438262,
0.014053061,
0.0036122303,
-0.010279187,
0.019727066,
0.018315163,
-0.011400793,
-0.030296551,
-0.00075832097,
0.0013319069,
0.0033846104,
-0.021772347,
0.051145222,
0.022075841,
0.013644004,
0.00090553175,
-0.009626017,
0.0001797868,
0.014857978,
0.007508161,
-0.0022910447,
-0.017035212,
0.00011700575,
-0.023725262,
0.007158484,
-0.021429269,
0.011110495,
0.030877147,
-0.009823947,
0.0011991286,
0.037791517,
-0.014699633,
-0.02497882,
-0.010391348,
0.0030695712,
0.02022849,
0.038530458,
0.0008758422,
0.01698243,
-0.0035627477,
0.016441422,
0.0022547576,
-0.00060739904,
-0.004364366,
-0.015174666,
-0.006079763,
-0.015412183,
0.01786652,
-0.003081117,
-0.0070595187,
-0.016283076,
0.011242448,
0.0047437325,
0.022089036,
-0.009177375,
-0.02040003,
-0.037817907,
-0.006769221,
0.017233143,
0.014343359,
-0.04122231,
-0.0052385586,
-0.009117995,
-0.006561394,
-0.0025615497,
-0.013248144,
-0.0029425658,
0.014792001,
-0.0008774916,
0.024147512,
0.020162513,
-0.0101340385,
-0.0037804712,
0.005357317,
-0.0008725433,
0.012265089,
-0.0015545785,
-0.030402115,
-0.016837282,
-0.0055123623,
0.011301828,
0.008002987,
0.009903119,
-0.0021640393,
-0.012298077,
0.016309468,
-0.028897842,
-0.0005909048,
-0.023791239,
0.023857215,
0.023382181,
0.008761721,
-0.012436628,
0.013168971,
-0.017813738,
0.01656018,
-0.015491355,
-0.017576221,
0.0015422079,
0.011169874,
-0.012779708,
-0.010787209,
0.009395097,
0.039902776,
-0.0233294,
-0.023434963,
0.003411001,
0.005106605,
0.012707134,
0.0017087994,
0.02842281,
-0.008524204,
-0.0066075777,
-0.006769221,
-0.017008822,
0.051039662,
0.006535003,
0.004344573,
-0.009573235,
0.0009937757,
-0.0010317124,
-0.123825274,
-0.002523613,
0.022260576,
0.029399266,
0.007805057,
0.006696646,
-0.019265229,
-0.00432478,
-0.013182167,
0.009804154,
0.004595285,
-0.021020211,
-0.021376487,
0.0119484,
0.028765889,
-0.03319953,
0.012872076,
-0.035653867,
0.005561845,
0.020004168,
0.013327315,
-0.0016601415,
0.005070318,
-0.015359402,
0.005611328,
-0.040245853,
-0.028581154,
0.010252796,
0.008115147,
0.01946316,
-0.0064459345,
-0.0039421143,
0.0043148836,
-0.02879228,
-0.016375445,
-0.021798737,
-0.008068964,
-0.042964097,
0.055314958,
-0.020004168,
0.015768457,
0.0019776549,
0.007534552,
0.004034482,
0.0067461287,
-0.006142441,
-0.03494132,
0.015636504,
0.033780128,
-0.006739531,
-0.02003056,
-0.0219043,
0.0092169605,
-0.0053210296,
0.038583238,
-0.04087923,
0.03454546,
-0.0020205397,
-0.0064657275,
-0.004839399,
-0.0004486423,
0.0020502293,
-0.008781513,
0.020795891,
0.011308425,
-0.014989931,
0.009540247,
-0.013056811,
0.01283249,
0.005251754,
-0.024451006,
-0.020888258,
-0.017510245,
-0.0075147585,
-0.030481286,
-0.024398224,
-0.006416245,
-0.011954998,
0.015451769,
-0.025071189,
-0.004440239,
-0.00204858,
0.032856453,
-0.028501982,
0.03235503,
-0.004113654,
0.0007570839,
-0.00847802,
-0.0006511086,
0.0043808604,
0.007877631,
0.036894232,
-0.0067362324,
-0.027393572,
0.0037309886,
-0.015755262,
-0.018526288,
-0.0036353222,
0.010483715,
0.0025071187,
-0.023540527,
0.00094759197,
-0.045497607,
0.0088211,
0.014316968,
-0.0052385586,
0.0050670193,
0.0018605461,
0.03061324,
-0.009447879,
-0.005357317,
0.015966387,
0.0016518944,
0.04702827,
-0.0012585076,
0.0021376486,
-0.0026357735,
-0.035231616,
0.005294639,
0.03354261,
0.002700101,
0.04227794,
-0.006597681,
0.015979584,
0.005977499,
0.0076928963,
-0.029372877,
-0.00486579,
-0.009533649,
0.023685675,
-0.013479062,
-0.0071320934,
0.0049350653,
-0.006083062,
0.007699494,
0.009863533,
-0.008200917,
-0.03934857,
0.014079452,
0.014514898,
0.034492675,
0.03895271,
-0.0018391036,
-0.016428227,
-0.0010622266,
0.010153831,
-0.0031569903,
0.01769498,
-0.018882563,
0.03713175,
0.0069077723,
0.015201057,
0.01838114,
-0.0045227106,
0.0090916045,
-0.022577265,
-0.022089036,
0.0057795686,
0.0057069943,
-0.004186229,
-0.022973126,
-0.015042713,
0.034492675,
0.0067890137,
-0.0036386212,
0.02677339,
0.0074751726,
-0.019449964,
0.00012803625,
-0.019423572,
0.0055090636,
-0.016916454,
-0.017404683,
-0.004918571,
0.0004762701,
0.030639632,
0.0015867422,
-0.0026209287,
-0.008240503,
0.009764568,
-0.0057630744,
0.018288773,
0.037976254,
0.012311273,
-0.017444268,
0.0075609423,
0.033753738,
0.02495243,
-0.024424614,
0.016599765,
0.02603445,
0.004222516,
0.008418641,
0.015095494,
0.019964583,
-0.012271686,
0.00927634,
0.006993542,
-0.0003919435,
0.0018127129,
0.002711647,
0.0050208354,
-0.00080697885,
0.01587402,
-0.008629767,
-0.032275856,
-0.015201057,
-0.01322835,
-0.02062435,
-0.034096815,
-0.014514898,
0.0030992606,
0.017351901,
-0.0027957673,
-0.024912843,
0.0020518787,
-0.014264187,
-0.0036122303,
0.00063750095,
-0.0022597057,
-0.014303773,
0.035205226,
-0.009738177,
0.023883605,
0.003988298,
-0.0043940553,
-0.0018819885,
0.019872215,
0.017879715,
0.0016972534,
0.004077367,
-0.009170776,
0.021811934,
-0.023975972,
-0.04560317,
-0.009593029,
0.0063667623,
-0.022141818,
0.016269881,
0.007976596,
-0.009414891,
0.0469491,
-0.018592265,
-0.009804154,
0.006267797,
-0.010859783,
0.01209355,
0.016428227,
0.009995487,
-0.0028749395,
-0.0273144,
-0.00055915344,
-0.033859298,
0.0033846104,
-0.028607545,
-0.032302245,
0.012990834,
0.0025912393,
0.032275856,
0.019186057,
-0.004845997,
0.010094452,
0.0053903055,
0.0011108846,
0.007956804,
-0.0060764644,
-0.011394195,
0.011691091,
0.002071672,
-0.008240503,
-0.01656018,
0.0070595187,
0.00429509,
-0.042093206,
-0.027261619,
0.025796933,
-0.01086638,
0.0026093828,
-0.035864994,
0.0022630047,
0.03393847,
-0.009982292,
0.01163831,
-0.019924996,
-0.007303633,
0.0051198006,
-0.019278424,
0.015135081,
-0.0031487432,
-0.009434684
] |
HER-2/neu amplification or overexpression can make cancer cells resistant to apoptosis and promotes their growth. p53 is crucial in regulating cell growth and apoptosis, and is often mutated or deleted in many types of tumour. Moreover, many tumours with a wild-type gene for p53 do not have normal p53 function, suggesting that some oncogenic signals suppress the function of p53. In this study, we show that HER-2/neu-mediated resistance to DNA-damaging agents requires the activation of Akt, which enhances MDM2-mediated ubiquitination and degradation of p53. Akt physically associates with MDM2 | [
-0.026076706,
-0.0038500587,
-0.02678079,
-0.029622728,
-0.022466676,
0.01770451,
-0.008877858,
0.028444989,
-0.022185043,
-0.008903461,
0.020098394,
-0.007328873,
0.013748838,
0.0032259843,
-0.013787242,
-0.01788373,
0.042501062,
0.0015721873,
-0.019496722,
0.010868494,
-0.019215088,
0.009818769,
-0.0089930715,
-0.028957048,
-0.0076105064,
0.03039082,
0.0061223293,
-0.039275076,
0.00090890826,
-0.018357387,
0.003827656,
0.0054214457,
-0.0061671347,
0.006291949,
-0.008244182,
0.011431761,
0.022351462,
-0.0074184835,
0.012039834,
0.016193928,
-0.0049669915,
0.004432528,
-0.008449006,
0.014542532,
-0.01267991,
-0.006599186,
0.016424356,
-0.014068875,
-0.011975827,
0.0069576288,
-0.005859898,
0.00864743,
-0.031850193,
0.0011145327,
-0.019803958,
-0.0167956,
-0.006906423,
0.041374527,
-0.0045349402,
-0.016898012,
-0.008865056,
-0.013928059,
-0.021199325,
0.020123996,
-0.00060127163,
0.015848288,
0.022492278,
0.010823689,
0.026473554,
0.002216264,
0.04122091,
0.033872835,
-0.009511533,
0.011956624,
-0.0029987572,
-0.023324378,
-0.034103263,
0.018114157,
-0.011886216,
-0.00604552,
0.027907323,
-0.03878862,
0.0010097203,
-0.0034564117,
0.024463713,
-0.0018018147,
-0.03392404,
0.009255502,
0.030954087,
-0.008301789,
0.009607544,
0.010484449,
0.009754762,
0.011566178,
0.0035876273,
0.027190438,
0.007712919,
0.011662189,
0.0034180072,
-0.017922135,
-0.0003476414,
0.015912294,
-0.0023650816,
-0.00831459,
-0.007674514,
0.004861379,
-0.0060647223,
-0.012577498,
0.005418245,
-0.003728444,
-0.009165891,
0.02921308,
-0.025603049,
-0.036893994,
0.031261325,
-0.011982227,
0.021186523,
0.017768517,
-0.010452445,
0.007028037,
-0.001965034,
0.01502899,
0.031286925,
-0.015464242,
0.02425889,
0.0026659176,
0.00663119,
0.0035140186,
-0.009453926,
0.0007608906,
0.036407538,
0.016078714,
0.028419385,
-0.0009073081,
-0.016219532,
0.011118124,
-0.017525287,
-0.018062951,
-0.013544013,
-0.02998117,
0.0176277,
0.030442026,
-0.014836967,
0.007239262,
-0.027164835,
0.01486257,
0.027292851,
0.015105799,
-0.0018530207,
0.018882249,
0.0017234052,
-0.0142737,
0.0055558616,
-0.022517882,
-0.0017602097,
-0.0090314755,
-0.026179118,
0.0044709323,
-0.024988577,
-0.020700065,
0.015451441,
0.010260422,
0.0035396216,
0.015886692,
0.020879287,
0.027574483,
0.004944589,
0.019266294,
-0.0013721634,
-0.0072520636,
0.012475085,
0.037918117,
-0.030288408,
0.014926578,
-0.03141494,
0.008493812,
0.0028499395,
0.026345538,
-0.026806392,
-0.0072264606,
-0.012974345,
0.027804911,
0.017269257,
0.012494288,
-0.02326037,
0.02637114,
0.021941813,
-0.020956095,
-0.0065127756,
-0.014388913,
-0.0016898012,
0.01578428,
-0.0023026743,
-0.01729486,
-0.6304495,
-0.0107276775,
0.00461815,
0.007079243,
-0.012859131,
0.041092895,
0.019176684,
0.0027683298,
-0.033155948,
0.022607492,
-0.021800997,
0.023490798,
-0.014478524,
-0.0123214675,
-0.017077234,
-0.03650995,
-0.015131402,
-0.03215743,
0.03156856,
-0.002585908,
-0.016437158,
-0.0021634577,
-0.016245134,
0.006256745,
-0.0022786714,
0.0235036,
0.008903461,
-0.011956624,
0.0201496,
0.04078566,
-0.027753705,
0.03005798,
-0.011265342,
0.0010233219,
0.04634152,
-0.004752566,
0.008551419,
0.023695622,
0.0176277,
0.035152987,
0.002174659,
0.007405682,
0.020712867,
0.0012329469,
-0.016667586,
0.011719796,
-0.007597705,
-0.0012401477,
0.014734555,
0.008071361,
-0.00015471842,
0.009978789,
-0.014785761,
-0.010004392,
0.007162453,
0.015694669,
0.019867966,
-0.02839378,
0.0008601024,
-0.0107084755,
0.019163882,
0.03246467,
-0.015861088,
-0.020303218,
-0.009754762,
0.016513966,
-0.0002988356,
0.009793166,
-0.013454403,
0.008276186,
0.034231275,
0.01696202,
0.0016769997,
0.025705462,
0.017614897,
0.04357639,
0.009383517,
0.016680386,
0.0020850482,
0.02921308,
0.01787093,
-0.018613417,
-0.046879184,
0.014990585,
0.022287454,
-0.0061863367,
-0.02418208,
0.03668917,
0.005357438,
0.008442606,
0.00028483392,
0.0045573427,
-0.022697104,
-0.02888024,
-0.005517457,
0.016667586,
-0.008705037,
0.0243485,
0.011758201,
-0.032285444,
-0.022146638,
-0.013134364,
0.0042597074,
0.0015633862,
0.020674461,
0.0003954471,
-0.029545918,
0.006573583,
0.041195307,
-0.013083158,
0.008551419,
0.0030835674,
0.019867966,
-0.013236777,
-0.002241867,
-0.027804911,
0.023375584,
0.030237202,
-0.0041957,
-0.024207683,
0.023401188,
-0.008160972,
-0.0074184835,
-0.03264389,
0.02880343,
0.013492807,
-0.010599663,
-0.008103365,
0.013480006,
-0.029161872,
0.0018546209,
-0.015899494,
0.00042685083,
-0.024284493,
0.013774441,
-0.002536302,
0.01939431,
0.006083925,
0.015105799,
-0.009204296,
-0.015003387,
0.0033059937,
0.016347546,
0.00028203358,
-0.003475614,
-0.014478524,
-0.020802477,
-0.0106316665,
0.013531212,
-0.006103127,
-0.0016882011,
0.0062535447,
0.00915309,
0.019803958,
0.025935888,
-0.013223975,
0.005171816,
0.0012033433,
-0.005485453,
-0.03289992,
0.012603101,
0.011796605,
-0.00043205146,
-0.0021026505,
-0.024284493,
-0.0075016934,
0.013659227,
0.013787242,
0.0017090036,
-0.02442531,
-0.018741433,
0.0014665746,
-0.023964453,
-0.0016898012,
0.017026028,
0.008346594,
-0.008436205,
-0.01191822,
0.0024482915,
0.008359396,
0.01972715,
-0.02980195,
-0.010932502,
-0.0036324325,
0.030416423,
0.043550786,
0.021301737,
-0.009773964,
-0.007949747,
0.027753705,
-0.02081528,
0.016731592,
-0.009274704,
0.035639446,
0.0025090987,
-0.03845578,
0.02619192,
0.011322948,
0.01611712,
0.035485826,
-0.020021584,
-0.023874843,
-0.009377117,
0.005744684,
0.017486883,
0.0062759477,
-0.0021042507,
-0.012641505,
-0.000629675,
0.0033956044,
-0.008103365,
0.017192448,
-0.024386905,
0.002376283,
-0.008660232,
0.005255026,
0.00064967736,
-0.005767087,
-0.016552372,
-0.020047188,
-0.0021282535,
-0.0062023387,
-0.0076425103,
-0.009197895,
0.017154044,
0.007239262,
0.026601568,
0.010087602,
-0.0028067343,
-0.00982517,
-0.008295388,
0.014350509,
-0.0038660604,
0.017576493,
0.0035492226,
0.0091082845,
0.0014665746,
-0.012814326,
0.027062424,
-0.0014129683,
-0.00085850223,
0.0044005243,
-0.014132883,
0.009652349,
0.020853683,
-0.011642987,
0.04188659,
0.013076757,
-0.022889126,
-0.0026307134,
0.0035428219,
0.0059719114,
-0.005223022,
0.005843896,
-0.00032403858,
-0.022185043,
0.005984713,
0.0018690226,
0.048543382,
0.01746128,
0.024194881,
-0.025974294,
0.00528703,
-0.010785284,
-0.0008617026,
0.009754762,
0.036049094,
-0.009249101,
0.0049829935,
0.007866537,
-0.011258941,
-0.00090490776,
0.010970906,
-0.029648332,
0.0123662725,
0.019688744,
-0.015912294,
0.019125478,
0.0040772855,
0.008967468,
-0.016769998,
-0.033949643,
0.042885106,
0.047314435,
-0.010362835,
-0.01552825,
-0.023298776,
-0.005667875,
0.0056806765,
0.0033956044,
-0.0031171713,
0.021391347,
-0.017077234,
-0.0014897775,
-0.01897186,
-0.014145684,
0.0139664635,
-0.001864222,
0.021288935,
0.0017506084,
0.015745874,
-0.0090058725,
-0.023542004,
0.0046469537,
0.021416951,
0.009421922,
0.010426842,
-0.0065863845,
-0.007463289,
-0.033104744,
-0.019663142,
-0.0027843316,
0.0059655104,
-0.023081148,
0.0019346304,
0.0029491512,
0.03225984,
0.0012001429,
0.0125967,
0.024374103,
-0.002661117,
-0.022722706,
-0.01385125,
-0.007764125,
0.028521797,
0.039607916,
-0.0028099346,
0.007565701,
-0.0072328616,
0.008096964,
-0.006365558,
-0.012071838,
0.02384924,
-0.03179899,
-0.011995029,
0.0019234291,
0.00052766287,
0.0069640293,
0.021544967,
0.0041284915,
0.017090036,
-0.017384471,
-0.019125478,
-0.018613417,
-0.0029283487,
-0.010337231,
0.034640927,
0.022965936,
0.040657643,
0.0089866705,
0.023529202,
0.014030471,
0.017077234,
-0.01040764,
-0.013646426,
0.0090442775,
0.0010121205,
0.020610455,
-0.005703079,
-0.028624209,
0.018421395,
0.0063623576,
0.0050598024,
-0.011137326,
0.008967468,
0.021685783,
0.012935941,
0.0022770711,
-0.000023052746,
-0.013377593,
-0.003030761,
0.012833528,
-0.0022098632,
-0.027267247,
0.011226937,
-0.006375159,
-0.042654682,
-0.0040004766,
0.020328822,
-0.0047749686,
-0.0051398124,
-0.007271266,
-0.016437158,
0.004896583,
0.013313586,
-0.0003292392,
0.016424356,
-0.012660708,
0.009370716,
-0.0015737874,
-0.007834533,
-0.0046341517,
-0.027088026,
-0.019778356,
0.008090564,
-0.035946682,
-0.017525287,
0.007911342,
0.020021584,
0.02217224,
0.0016241934,
0.0016545971,
-0.016859608,
0.015387433,
-0.015758676,
-0.015413036,
-0.0142737,
-0.05089886,
0.00020252413,
-0.018011745,
-0.0045797452,
-0.027164835,
-0.0051494134,
0.020252012,
0.0044517303,
-0.017512485,
0.028240163,
0.008634629,
-0.005559062,
0.010215617,
0.007098445,
0.014683349,
0.017320463,
0.032055017,
0.0032227838,
-0.02913627,
-0.047980115,
-0.030288408,
-0.022812316,
-0.02880343,
0.0019874368,
0.011265342,
-0.008199377,
-0.0072072586,
0.0035300204,
0.0064551686,
-0.009300307,
-0.0020354425,
0.014683349,
0.015323425,
0.0122510595,
0.008794648,
-0.010529254,
-0.00023282773,
-0.019368706,
-0.012948742,
0.020866485,
-0.0054054437,
-0.0038660604,
0.006154333,
-0.0090890825,
-0.012494288,
-0.016385952,
-0.0067144,
-0.007098445,
0.03425688,
0.024374103,
-0.006599186,
-0.0027763306,
-0.012955143,
-0.00822498,
-0.0017570093,
-0.0019890368,
-0.008320991,
-0.018267775,
0.015310624,
0.008282586,
-0.02795853,
0.026345538,
-0.03292552,
-0.024079667,
0.0394543,
0.011636586,
-0.01225746,
-0.0027027219,
-0.006541579,
-0.026755186,
-0.01865182,
-0.02451492,
-0.035639446,
0.014811364,
0.01419689,
0.033053536,
0.053356756,
0.021941813,
0.008000953,
0.023145156,
0.026934408,
0.005984713,
0.0010705275,
-0.01301915,
0.02226185,
-0.014657746,
0.03325836,
-0.002611511,
-0.0021970617,
0.033309568,
0.0218394,
0.013953662,
-0.00020092393,
0.00848101,
-0.005559062,
0.006442367,
-0.03264389,
-0.0243485,
0.015835486,
-0.019035866,
-0.0003712442,
-0.049081046,
0.0076361094,
0.0067208004,
0.01419689,
-0.0013361592,
0.0041764975,
-0.007540098,
-0.020367226,
0.025385423,
0.0018274176,
-0.0037316445,
-0.008666632,
-0.012609501,
0.016245134,
0.0022706704,
0.010894097,
0.0090634795,
0.02039283,
-0.0068360143,
-0.016936418,
-0.01100291,
-0.000096261465,
-0.021263333,
-0.03064685,
-0.022210645,
-0.0218394,
-0.030416423,
0.006288749,
0.000310637,
-0.021212127,
0.0057158805,
0.010106804,
-0.028112149,
0.012123044,
0.0046661557,
-0.00948593,
0.02611511,
-0.013620823,
0.029904362,
-0.0062343427,
0.015669066,
0.0077769263,
0.011732597,
-0.016731592,
-0.017320463,
-0.02383644,
0.018421395,
0.036561154,
0.013838449,
0.0022738709,
0.009377117,
0.00302276,
-0.0028179355,
-0.0028035338,
-0.00932591,
0.034231275,
-0.008493812,
0.0070856437,
-0.0034980166,
-0.023964453,
-0.030109186,
-0.007245663,
-0.008762644,
0.017653303,
0.006522377,
-0.016014708,
-0.024412507,
0.0072840676,
-0.002787532,
0.021058507,
-0.0030083582,
-0.018331783,
-0.015080196,
-0.017755715,
0.006848816,
-0.0037220432,
-0.019586332,
0.020175204,
0.0044709323,
-0.0056390716,
0.021199325,
-0.0260383,
0.0016721991,
0.001913828,
-0.011207735,
0.033027932,
-0.0123726735,
-0.00562627,
0.010286025,
-0.016411554,
0.004179698,
0.007271266,
-0.0019010265,
-0.022517882,
-0.029033858,
-0.0012225456,
0.0045381407,
0.01100291,
-0.01100291,
-0.0022642696,
-0.025846278,
-0.018062951,
-0.022069829,
-0.008929064,
0.008589823,
-0.03650995,
-0.026908806,
-0.023516402,
-0.00026663175,
0.028521797,
0.004240505,
-0.017486883,
-0.0066375905,
0.052255824,
-0.025462233,
-0.004122091,
0.012935941,
-0.015541051,
-0.011649388,
0.01687241,
-0.009556338,
-0.024194881,
-0.0015689869,
-0.022901928,
-0.027753705,
-0.021865005,
-0.018677425,
0.01536183,
0.017333264,
-0.012974345,
0.020930493,
0.011732597,
0.018843845,
-0.009729159,
-0.00604232,
0.001864222,
-0.0012193453,
0.00864743,
0.013211173,
-0.008916262,
-0.043013122,
-0.004307713,
-0.0037828505,
0.0016545971,
0.0003878462,
-0.014132883,
-0.013876853,
-0.005162215,
0.002987556,
0.004339717,
-0.0056038676,
0.0032675893,
-0.0193175,
0.017064432,
0.024604531,
0.015400235,
-0.014491326,
-0.009626746,
-0.01200143,
0.010612464,
-0.029904362,
-0.0062279417,
-0.018882249,
-0.02569266,
-0.037252437,
-0.010036395,
-0.015208212,
0.01469615,
0.016859608,
-0.017422875,
-0.012750318,
-0.015387433,
-0.031927,
-0.020994501,
-0.006291949,
0.00352682,
0.008007354,
0.024834957,
-0.024847759,
-0.011374155,
0.02208263,
0.028573003,
0.0037060415,
-0.013287983,
0.0058726994,
-0.015323425,
0.021263333,
-0.007604106,
-0.016142722,
-0.008474609,
0.024476515,
-0.02241547,
-0.035485826,
0.026908806,
-0.029289888,
0.012980746,
-0.0061991382,
0.0011121324,
0.014068875,
0.03323276,
0.026627172,
-0.013505609,
-0.0038052532,
0.01612992,
0.021647379,
-0.0028483393,
0.0027843316,
0.014849769,
0.01209104,
-0.001368963,
0.0037540472,
-0.033949643,
-0.003878862,
-0.0069832318,
0.028419385,
0.034717735,
-0.007047239,
0.0155794555,
-0.00007650911,
-0.0013273581,
-0.018754235,
0.002576307,
-0.013063956,
-0.007520896,
0.009946785,
-0.002542703,
-0.034205675,
-0.0074248845,
0.012660708,
-0.018831043,
-0.020930493,
0.0054310467,
-0.007514495,
-0.038225353,
0.0054214457,
-0.0052422243,
0.006656793,
-0.0070344377,
-0.010164411,
-0.014683349,
-0.010247621,
-0.009332311,
-0.000030028576,
0.011771002,
-0.012878334,
-0.0063463557,
0.0045829457,
-0.00062887487,
-0.012539093,
-0.025974294,
-0.014222494,
0.016898012,
0.19960137,
-0.011060517,
-0.0019842363,
0.015374631,
0.008711438,
-0.000023977856,
0.017781317,
-0.012526291,
0.011975827,
-0.012667108,
-0.0044357283,
0.023618814,
-0.011745399,
-0.0053030318,
0.018421395,
-0.011047715,
-0.038583796,
0.010554857,
-0.009287506,
-0.000110013105,
0.03384723,
-0.014401715,
0.011239738,
0.0013033552,
0.042526666,
-0.005239024,
-0.036433138,
0.009652349,
0.014875372,
-0.01486257,
-0.03763648,
0.0004896583,
0.020892087,
0.0030627649,
-0.0042693084,
0.010017193,
-0.029545918,
-0.020520844,
0.0018562211,
-0.018626219,
0.0016850007,
0.019074272,
-0.004230904,
0.038404573,
-0.009927582,
0.012948742,
-0.0053286348,
-0.0049509895,
0.0067208004,
-0.013300784,
-0.042219426,
-0.008192976,
0.0076169074,
0.028854636,
-0.019240692,
0.0071432507,
0.021532165,
-0.008967468,
-0.025295813,
0.028316973,
-0.019931974,
-0.009978789,
-0.041656163,
0.03341198,
-0.019343104,
0.01729486,
-0.03256708,
0.010881296,
0.020917691,
-0.01628354,
-0.009985189,
0.0052166213,
-0.018677425,
0.0010401239,
-0.009940384,
-0.010804486,
0.024105271,
0.008570621,
0.035332207,
0.01385125,
0.013121563,
0.020277616,
-0.00881385,
0.0030531636,
-0.0060583213,
-0.032541476,
0.021096913,
0.017512485,
0.007565701,
-0.01670599,
-0.0003996476,
-0.0017330064,
-0.0069192243,
0.0067464034,
-0.006365558,
0.016821204,
-0.012219056,
0.007732121,
-0.017090036,
-0.027804911,
-0.03333517,
0.07143251,
-0.013159967,
0.0031427743,
-0.0037124422,
-0.012039834,
0.0067528044,
0.027804911,
0.00020102394,
-0.011162929,
0.00805856,
-0.029673934,
-0.0012113443,
-0.010196415,
0.012411078,
0.013454403,
0.0069832318,
-0.0031091704,
0.017947737,
-0.025039783,
-0.006759205,
-0.032976728,
-0.011822208,
0.043858025,
-0.011047715,
0.013134364,
-0.036279522,
-0.0045989477,
0.009869976,
-0.028624209,
0.02502698,
0.011681391,
-0.006842415,
0.014760158,
0.024706943,
-0.0026947209,
0.014952181,
-0.011489368,
-0.004986194,
0.03407766,
-0.011310147,
0.0036644365,
-0.004138093,
0.01906147,
-0.00045325398,
-0.029443506,
0.013300784,
0.020123996,
0.0013377593,
-0.014734555,
-0.0069960332,
-0.015285021,
-0.0123534715,
0.0014241696,
0.011694193,
-0.040990483,
-0.02795853,
-0.01661638,
0.005869499,
0.013633624,
-0.008449006,
0.0017858127,
0.020840881,
-0.02442531,
-0.0067144,
0.005901503,
-0.15812443,
0.008583423,
0.01292954,
-0.04088807,
0.028905842,
0.01628354,
-0.011899017,
-0.012481486,
-0.002753928,
0.020687263,
0.017474081,
-0.01183501,
-0.035460223,
-0.009748361,
0.0060967263,
0.008103365,
0.014913776,
0.027804911,
0.013031952,
0.00201464,
0.017973341,
-0.014542532,
0.02736966,
0.0123342695,
-0.0064935735,
0.005002196,
-0.0142737,
-0.019240692,
-0.021506561,
0.0037092417,
-0.017435677,
0.0044613313,
0.03179899,
-0.010932502,
0.015041792,
0.0033604002,
-0.013390395,
-0.0074184835,
-0.011649388,
0.008429804,
0.017486883,
0.014465723,
-0.0020706465,
0.0054534497,
0.0013225576,
0.03484575,
0.0139152575,
0.0013905657,
0.0030499632,
-0.00008976069,
0.03492256,
0.0020530445,
0.002779531,
0.011988628,
0.0019858365,
0.0021890607,
0.010497251,
-0.000024540423,
-0.013723235,
-0.0030339614,
0.0037924517,
-0.0065607815,
0.03458972,
0.011559777,
-0.024118073,
-0.05632671,
-0.02200582,
0.021327341,
-0.0411441,
0.004355719,
-0.003536421,
-0.0051238104,
0.023413988,
-0.035281003,
0.02678079,
0.010202815,
-0.0006588785,
0.014184089,
0.0026659176,
0.006932026,
-0.0034308087,
0.00097291585,
-0.034871355,
-0.011694193,
-0.014452921,
-0.01133575,
0.008513014,
0.025295813,
0.0020882487,
-0.0051686154,
0.010126006,
-0.00044885345,
-0.0073416745,
-0.034666527,
0.024630133,
0.006733602,
-0.00293795,
-0.0031027696,
-0.016513966,
0.003224384,
0.0124174785,
-0.010868494,
-0.021455355,
0.0014553734,
0.04552222,
-0.006541579,
-0.015797082,
0.003718843,
0.062317822,
-0.020008784,
-0.00037464462,
0.0065799835,
-0.005418245,
0.024566125,
0.00654798,
0.019023066,
0.025513439,
0.0006692797,
-0.010548457,
-0.015643463,
0.08085443,
0.015003387,
0.0035556236,
0.009780365,
-0.0053030318,
-0.031261325,
-0.1369251,
-0.03223424,
0.028496195,
0.02167298,
-0.024233285,
0.01897186,
-0.0012665509,
0.016424356,
-0.011450964,
0.043627597,
-0.0106764715,
-0.014811364,
0.0046149497,
-0.000008801048,
0.011847811,
-0.009914781,
0.014555333,
0.006355957,
-0.011406158,
0.03208062,
-0.01310236,
0.0029523517,
0.01612992,
-0.0243485,
0.0075593004,
-0.006740003,
-0.042014603,
0.02158337,
0.00030283607,
0.0053382358,
0.007597705,
-0.02292753,
0.032387856,
-0.002905946,
-0.024694141,
-0.022236248,
-0.005245425,
-0.029776346,
0.029289888,
-0.0011625384,
-0.011495769,
0.02226185,
0.025667056,
0.0033059937,
-0.010804486,
-0.02703682,
0.0019122277,
0.010868494,
0.010791685,
-0.018715829,
-0.033898436,
-0.011559777,
-0.029033858,
0.015720272,
0.004570144,
-0.0090506775,
0.031133307,
0.023221966,
-0.008717839,
-0.006733602,
0.0033475987,
0.000020914991,
-0.021903409,
0.005891902,
0.01880544,
0.0010481249,
-0.028240163,
-0.0310565,
0.027420865,
-0.010068399,
0.006154333,
0.0056902776,
-0.0134288,
-0.008583423,
-0.029315492,
0.019330302,
-0.0106828725,
-0.02040563,
0.024553325,
-0.015771478,
-0.02477095,
-0.011041315,
0.014785761,
-0.02259469,
0.048901822,
-0.023977255,
-0.004835776,
-0.00831459,
0.018421395,
-0.003914066,
-0.00091290876,
0.043627597,
-0.0046501537,
-0.020636057,
-0.008653831,
0.011137326,
-0.006423165,
-0.013108761,
0.004877381,
0.027984133,
-0.025539042,
-0.025423829,
-0.043371566,
0.0089930715,
-0.0066375905,
0.006371959,
0.027907323,
-0.002862741,
0.01040764,
-0.0064263656,
0.006359157,
0.011028513,
-0.0012753519,
0.0027251246,
-0.0023570808,
-0.016027508,
-0.026883202,
-0.013377593,
0.02384924,
-0.019343104,
-0.008769045,
0.039684728,
-0.0052102203,
-0.008384999,
0.008084163,
-0.0037252437,
0.0035620243,
-0.021544967,
-0.009101884,
0.012827128,
-0.013044754,
0.004454931,
0.018843845,
-0.056070678,
-0.015553853,
-0.005786289,
-0.0007252864,
-0.022377064,
-0.01771731,
0.018587815,
0.019023066,
0.02486056,
-0.0052262223,
-0.035716254,
-0.0035588238,
-0.010740479,
0.0053414362,
-0.0017810122,
-0.038814224,
0.0005260627,
0.00579269,
0.006000715,
0.033975247,
0.006480772,
-0.010388438,
-0.028163355,
-0.011194933,
0.0022146637,
-0.016577974,
-0.024233285,
-0.03484575,
-0.013672029,
0.000604472,
0.013134364,
0.017947737,
0.009850773,
-0.0030339614,
-0.0015017788,
-0.029571522,
0.0030771664,
0.0062759477,
-0.016565172,
-0.007380079,
-0.010343632,
0.012705513,
-0.005802291,
0.0156050585,
-0.0013705633,
-0.019586332,
-0.005194219,
-0.008532216,
0.01368483,
0.0066439915,
0.0013401596,
-0.019496722,
0.012737517,
0.019842364,
-0.0025699062,
-0.016680386,
-0.010254021,
0.020098394,
-0.004464532,
0.0050085965,
0.0369708,
0.01083649,
0.010138808,
0.015221013,
0.025257409,
-0.018114157,
-0.0062119397,
0.0037988524,
0.023862042,
-0.00823138,
0.000084010004,
-0.004374921,
-0.010766082,
-0.010548457,
0.018370189,
-0.02375963,
-0.038737413,
-0.0048677796,
0.0090122735,
-0.0019362306,
0.012494288,
0.012494288,
-0.0020498442,
-0.0039492706,
0.016552372,
0.019202286,
-0.007290468,
-0.014593738,
0.037482865,
0.021186523,
-0.0027187238,
-0.006499974,
-0.001184141,
0.028957048,
0.006240743,
0.008660232,
-0.015694669,
0.026550362,
-0.018690227,
0.029571522,
-0.01486257,
-0.051359717,
-0.028086545,
-0.006900022,
-0.016552372,
0.0047813696,
0.022133837,
-0.02007279,
0.08418283,
0.011623784,
-0.01536183,
-0.01419689,
-0.0107212765,
0.012686311,
0.0011185332,
0.0037796502,
-0.024194881,
-0.035306606,
0.007597705,
-0.016001906,
0.025014179,
-0.037098818,
-0.02209543,
0.023542004,
-0.009293907,
-0.0014209693,
0.004355719,
0.0077897278,
0.006893621,
-0.010804486,
-0.020533646,
0.019138278,
-0.033309568,
0.0066887964,
0.035152987,
0.027830515,
0.007597705,
-0.014222494,
0.003325196,
-0.019432714,
-0.026153514,
-0.012731116,
0.01703883,
-0.017768517,
-0.007482491,
-0.03005798,
0.016488364,
0.034103263,
-0.002107451,
0.007828132,
-0.007674514,
-0.041784175,
0.012923139,
0.000780893,
0.004742965,
-0.011156529,
0.00090490776
] |
T cell memory induced by prior infection or vaccination provides enhanced protection against subsequent microbial infections. The processes involved in generating and maintaining T cell memory are becoming better understood due to recent technological advances in identifying memory T cells and monitoring their behavior and function in vivo. Memory T cells develop in response to a progressive set of cues-starting with signals from antigen-loaded, activated antigen-presenting cells (APCs) and inflammatory mediators induced by the innate immune response, to the poorly defined subsequent signals triggered as the immune response wanes toward homeostasis. The persistence of the resting memory T cells that eventually develop is regulated by cytokines. This chapter discusses | [
-0.018891905,
-0.0016293944,
-0.0047424124,
-0.017388845,
-0.03241944,
0.009316378,
0.0063880035,
-0.030501744,
-0.02061524,
-0.014097663,
0.01245855,
0.0029445714,
-0.011409,
-0.009938334,
-0.011020278,
0.011370128,
0.05107811,
0.013695983,
-0.009186804,
-0.0012592983,
-0.033844758,
0.023608401,
0.005014518,
-0.007936414,
0.011681106,
0.006880385,
-0.007897542,
-0.05530223,
-0.013605281,
-0.006365328,
-0.010178046,
-0.01341092,
-0.020174688,
-0.009899462,
-0.008448232,
-0.029465152,
0.0024505702,
-0.023297423,
0.03768015,
0.016922379,
0.012147572,
0.0242174,
-0.0014933415,
0.009854111,
0.016274508,
-0.0021039594,
0.0003152295,
-0.013138814,
0.008545413,
0.008778646,
0.018503182,
0.003987643,
-0.010152131,
0.013022197,
-0.022105342,
-0.019202882,
-0.023906423,
0.034103904,
0.011136894,
-0.050948538,
-0.006433354,
0.0103659285,
0.00010203961,
-0.0037965213,
0.016080147,
0.015458191,
0.005108459,
0.02346587,
-0.0020553693,
0.016287465,
0.013890344,
0.03166791,
-0.006073786,
0.010016078,
0.017077867,
-0.019954411,
-0.016196763,
-0.009128496,
-0.013488664,
0.010800001,
0.008143732,
-0.03713594,
0.013566409,
0.038353935,
0.012866708,
0.015950572,
0.009439474,
0.00051222264,
0.011985605,
-0.008351051,
0.0242174,
0.030190766,
0.011752372,
0.023128977,
0.0147455335,
0.026847754,
0.0034239958,
0.025590885,
-0.009484825,
-0.024761612,
-0.012179966,
0.01376077,
-0.021820279,
-0.013229516,
-0.036099344,
0.00069970015,
0.0026740856,
0.0018820639,
0.028817281,
-0.009925377,
-0.0046193167,
0.023388127,
-0.018127417,
-0.054421123,
0.0018820639,
0.031486508,
-0.011681106,
-0.01596353,
-0.013385005,
-0.018295864,
0.008713858,
0.018334735,
0.028506303,
0.00330252,
0.007968808,
0.005464788,
-0.008117817,
-0.0018788246,
-0.0025056393,
0.0034693466,
0.0043342537,
0.03762832,
-0.019073308,
0.0048331143,
-0.021094665,
0.013333175,
-0.0072691073,
0.0033138578,
-0.009582005,
-0.0008102431,
0.0006199311,
0.031020042,
0.001315987,
0.008875826,
0.01856797,
0.019721178,
0.022558851,
0.020006241,
-0.014680746,
0.023841636,
-0.018749373,
-0.03768015,
-0.0096338345,
-0.00870738,
-0.0008446612,
0.004868747,
-0.017609121,
0.011052671,
-0.015937615,
-0.025487227,
0.015652552,
-0.014369768,
0.0241267,
0.009167368,
0.0021331138,
0.033456035,
0.009076666,
0.016248593,
-0.00195171,
-0.0046808645,
-0.0057368935,
0.03703228,
-0.02042088,
0.027314221,
-0.032445356,
0.023128977,
0.000009085372,
0.008344572,
-0.020096943,
-0.022286747,
-0.011136894,
0.01626155,
0.013093463,
-0.014123578,
-0.030786807,
-0.00059280155,
0.02816941,
-0.015043554,
-0.013223037,
-0.0016285846,
-0.009750451,
-0.009860589,
-0.007625436,
-0.03241944,
-0.6256874,
-0.020174688,
0.026795926,
-0.0007414068,
0.0061126584,
0.017129697,
0.005257469,
-0.026536778,
-0.045325022,
0.025007803,
0.008111339,
0.012490944,
0.016598443,
-0.017246313,
-0.015341574,
-0.032263953,
-0.0022983206,
-0.0022594484,
0.019306542,
-0.0066406727,
0.0006592083,
0.003608639,
-0.010048471,
0.01981188,
-0.02956881,
-0.0063523706,
0.019669348,
-0.0038256755,
-0.013527537,
0.052062877,
-0.0050307144,
0.016637316,
0.011583925,
-0.011091543,
0.03962376,
0.008849911,
-0.01785531,
0.006569407,
-0.0058599887,
0.020083986,
0.0033397726,
-0.017557291,
0.004292142,
0.010288184,
-0.01030762,
0.03451854,
-0.023180807,
0.0003958084,
0.015017639,
-0.030242596,
0.01896965,
0.008493583,
-0.036462154,
-0.01641704,
0.018218119,
0.003266887,
0.003867787,
0.0030854833,
0.0144604705,
0.001135393,
0.009147932,
0.011635754,
-0.0050922623,
-0.024424719,
-0.023841636,
0.016987165,
-0.0034239958,
-0.010968448,
0.016870549,
-0.025642715,
0.01150618,
0.033741098,
-0.0065110987,
-0.0061320947,
0.0041787648,
0.030138938,
-0.00085599895,
-0.02157409,
0.00780684,
0.011797722,
-0.009860589,
-0.015497063,
-0.022377448,
-0.0023128977,
-0.012976847,
-0.011868988,
-0.023750933,
0.0038353936,
0.00815669,
0.020654112,
0.019785967,
-0.0075995214,
0.0022351532,
-0.069710866,
-0.036358494,
0.033844758,
-0.01795897,
-0.006158009,
-0.008668507,
0.0031502703,
-0.008752731,
0.00012765074,
0.028402643,
0.012037435,
0.032963652,
-0.011013799,
-0.01830882,
0.00053651776,
0.059863236,
-0.014525257,
0.0242174,
0.006413918,
0.008882305,
0.0010001501,
-0.0018982607,
-0.009588484,
0.021029877,
0.02666635,
0.006034914,
-0.014019919,
0.036539897,
0.0019338935,
0.01486215,
0.0064527905,
0.0014811939,
0.029465152,
-0.008189083,
-0.0035082188,
-0.0028085187,
-0.0043990407,
0.014784405,
-0.006209839,
0.020783687,
-0.0053319745,
0.004778045,
0.0028295745,
0.022545895,
0.0059474516,
0.010605641,
-0.030087108,
-0.030994127,
-0.0073468518,
-0.0059539303,
-0.009445952,
-0.023789806,
0.00280204,
0.0105991615,
0.0073338943,
-0.012678826,
-0.015510021,
0.023828678,
-0.012776007,
0.00030247454,
-0.003062808,
0.0430186,
-0.0025250753,
0.0028376728,
-0.024800483,
-0.01045663,
-0.0092710275,
-0.011570968,
0.028247155,
0.001416407,
0.0115904035,
-0.0014390824,
-0.017233357,
-0.0018107981,
0.012568688,
0.011998562,
-0.052114706,
0.016196763,
-0.03293774,
-0.024152612,
0.016235635,
0.0092710275,
0.0047974815,
-0.018827118,
-0.01335909,
0.007975286,
-0.019760052,
0.006530535,
-0.0016520699,
0.023634316,
-0.011020278,
0.032911822,
-0.003108159,
0.0121087,
-0.009892983,
0.018827118,
0.043666475,
-0.0005514998,
0.01916401,
-0.024839357,
0.0056526703,
-0.012963889,
-0.021638876,
0.0046452316,
0.01811446,
0.027029159,
0.022934617,
-0.027236477,
-0.0076578297,
0.00021663171,
-0.019980326,
0.017129697,
-0.036747217,
0.0006211459,
-0.029646555,
0.030475829,
0.0004628225,
-0.0065726466,
-0.01841248,
0.0037965213,
-0.0059506907,
0.011901381,
0.014978766,
0.0045545297,
0.012879666,
-0.019345414,
-0.027417881,
-0.0062681474,
0.010152131,
0.007742053,
-0.027080989,
-0.025241036,
0.009348772,
0.020874389,
-0.0008236054,
-0.027547454,
-0.014641874,
-0.015380446,
0.004078345,
0.014097663,
0.0032701264,
0.020200603,
0.023310382,
-0.00007070899,
-0.0063588494,
0.026459033,
0.014149493,
-0.0008568088,
0.023336297,
-0.008636114,
0.0016455911,
-0.015639594,
0.0059215366,
0.024282187,
0.011182245,
-0.0016383026,
0.001976005,
-0.018334735,
-0.021107621,
-0.018529097,
-0.010547332,
-0.028817281,
-0.014758491,
0.018347694,
-0.010314099,
0.05239977,
0.017635036,
0.014732576,
-0.0003937838,
0.018347694,
-0.012626996,
-0.0007871627,
-0.006997002,
0.009329336,
-0.033481948,
-0.008966528,
-0.003657229,
-0.031408764,
-0.008169647,
0.017492505,
-0.021289026,
0.0010973307,
0.024243316,
0.013968089,
0.004794242,
-0.0031389326,
0.0048298747,
-0.013268389,
-0.028920941,
0.012989804,
0.025150334,
0.0002482154,
-0.003417517,
-0.032911822,
-0.028869111,
-0.0030838638,
-0.005315778,
-0.006161249,
0.0283249,
-0.015393403,
-0.023310382,
-0.007871627,
-0.0039908825,
0.043510985,
0.0023031798,
0.02767703,
0.0012034195,
-0.0006681165,
-0.0010033895,
-0.037861552,
0.0005628375,
0.0049464917,
-0.00028708763,
0.009582005,
-0.016766889,
-0.022377448,
-0.002811758,
-0.0016682666,
-0.007826276,
0.0069840443,
-0.025500184,
0.027988007,
0.014654831,
0.0017994604,
0.020654112,
0.021276068,
-0.0065175775,
-0.0036118783,
-0.026588606,
0.0023258552,
0.0012220457,
0.030916382,
0.023271509,
-0.01891782,
0.009050751,
-0.021923939,
0.0180108,
-0.0010495503,
-0.0020440314,
0.0325231,
-0.0013378527,
-0.027547454,
0.008351051,
0.018256992,
-0.0040621483,
0.01335909,
0.017505461,
0.01195969,
0.011797722,
-0.0059766057,
-0.0012617279,
0.020628197,
0.004512418,
0.016326338,
0.030734979,
0.028195325,
-0.02446359,
0.00740516,
0.021353813,
-0.0018043194,
-0.04089359,
0.010929576,
-0.005079305,
-0.00012846058,
-0.0044346736,
0.0040297545,
0.0147973625,
-0.005435634,
0.022092385,
0.0060673077,
-0.0038839837,
0.030734979,
0.031434678,
0.008260349,
-0.0077679674,
0.0064074397,
0.0065467316,
0.023478828,
0.0042435518,
0.016870549,
0.00026542446,
0.017427716,
-0.0034142777,
-0.016559571,
-0.024437677,
-0.009329336,
0.007210799,
-0.0029283748,
0.009562569,
-0.011849551,
0.012251232,
-0.018438395,
-0.027417881,
0.011674627,
-0.016274508,
-0.02677001,
-0.018723458,
0.0071136183,
0.008817518,
-0.015976487,
-0.023491785,
0.0053028204,
-0.014382726,
-0.024852313,
0.011143373,
-0.0053514107,
0.025979608,
0.013644153,
0.0014415119,
-0.016598443,
0.036513984,
0.0060511106,
-0.00820852,
-0.0037706064,
-0.026394244,
0.01701308,
0.0073922025,
0.010961969,
-0.029646555,
-0.013449792,
0.0014342234,
-0.0048039597,
-0.017142653,
0.008985965,
0.0066471514,
-0.0037187769,
0.023776848,
0.026692266,
0.010942534,
-0.00400384,
-0.019267669,
-0.020200603,
-0.028661791,
-0.00665363,
-0.00040066743,
0.0004927865,
-0.01580804,
-0.0069127786,
0.011843073,
-0.00004006168,
-0.026264671,
-0.0068933424,
-0.02507259,
0.004564248,
-0.00021399974,
0.010702821,
0.043899707,
0.016404081,
0.007184884,
0.011914339,
-0.012730656,
-0.01620972,
-0.026484948,
0.012296583,
0.010100301,
-0.016728017,
-0.013333175,
-0.0030449915,
0.0044249557,
-0.0084093595,
-0.018749373,
-0.014888065,
0.024955973,
-0.0013678167,
0.007366288,
-0.0022205762,
-0.01781644,
0.026329458,
0.01836065,
-0.0053643677,
-0.026199885,
-0.012387284,
0.01025579,
0.0023728258,
-0.007975286,
0.047761016,
-0.03998657,
0.00023910472,
0.0064819446,
0.018295864,
0.0084871035,
0.0050825444,
0.006339413,
-0.026135096,
0.016831676,
-0.014253152,
-0.050896708,
-0.0033009003,
0.0063685672,
0.039001804,
0.02201464,
0.0084352745,
-0.018101502,
0.00670546,
0.0073986812,
0.0059474516,
0.0054907026,
-0.01516017,
0.034596287,
-0.018269949,
-0.010553811,
-0.0065175775,
-0.014032875,
-0.0007486954,
-0.021936895,
0.025694545,
0.016054232,
-0.0010714158,
-0.012665869,
-0.0038191967,
-0.008098382,
-0.027962092,
0.021949854,
0.0045318543,
0.0145900445,
-0.019604562,
0.0094524305,
0.009646792,
0.026264671,
0.011279426,
0.011681106,
0.02316785,
-0.010404801,
0.016818719,
-0.024346974,
-0.011674627,
-0.017984886,
-0.017738694,
-0.01100732,
0.0008159119,
0.02772886,
-0.0066471514,
-0.004224116,
0.016002402,
0.00850654,
0.0038839837,
-0.0017573488,
-0.015522977,
-0.04078993,
-0.0180108,
-0.011318298,
-0.04693174,
-0.009083144,
-0.0126853045,
-0.0065726466,
-0.0073533305,
0.0073792455,
-0.007625436,
0.0097051,
-0.020433836,
-0.020991005,
0.015950572,
-0.024852313,
0.030009363,
-0.027210562,
0.015950572,
0.0069063,
0.011402521,
-0.0029348535,
-0.010916619,
0.0024246555,
0.017427716,
0.027236477,
0.03016485,
-0.0042500305,
-0.034699947,
0.022273788,
0.015626637,
0.015250872,
-0.019436115,
0.03021668,
0.0053254957,
0.0036475111,
-0.031305104,
-0.026303543,
-0.023478828,
0.01680576,
-0.009543133,
0.0044994606,
0.017803483,
-0.0044217166,
-0.024683867,
0.0067832046,
-0.006945172,
-0.00395201,
-0.018503182,
-0.027314221,
-0.0065434924,
-0.035321902,
0.003922856,
0.007320937,
-0.01236137,
0.012341933,
0.000023675113,
-0.009569048,
0.024489505,
-0.020058071,
0.003958489,
0.023491785,
0.0013192263,
0.035062753,
-0.0042403126,
-0.0021703662,
-0.019176967,
0.00016885126,
0.0025607082,
-0.021263111,
0.0029348535,
-0.004509179,
-0.0051732464,
0.0050307144,
0.013955131,
-0.0053611286,
-0.013683026,
-0.009432995,
-0.022947574,
-0.0021736056,
-0.011551531,
-0.017492505,
0.0044865035,
-0.029594725,
-0.0073727667,
0.0076837447,
0.001085993,
0.012154051,
0.0003431689,
0.010832395,
-0.0147714475,
0.020874389,
-0.028895026,
0.017077867,
0.0121087,
0.012471507,
-0.005014518,
0.0059474516,
-0.00895357,
-0.026057353,
0.016170848,
-0.02026539,
-0.051855557,
-0.013041634,
-0.0065272953,
0.024580209,
-0.019241754,
-0.011480265,
0.024994845,
0.015458191,
0.0094265165,
0.0096079195,
-0.025953693,
0.022027599,
-0.017129697,
-0.022351533,
0.0276252,
-0.044469833,
0.0038613083,
0.010644513,
0.010281705,
0.019773008,
-0.025344694,
-0.032497186,
-0.018023757,
-0.00011843883,
-0.029361492,
-0.008610199,
0.000820366,
-0.006264908,
0.0024602883,
-0.0031211162,
0.011331256,
-0.013618238,
-0.014071748,
0.009225676,
0.024774568,
0.019643435,
-0.01596353,
0.008085424,
0.0037090587,
-0.013333175,
-0.0147196185,
-0.0042500305,
-0.036850877,
0.027495624,
-0.006073786,
0.010242833,
-0.020343134,
0.001896641,
-0.06608279,
-0.0039358134,
0.029465152,
0.0065078596,
0.03988291,
0.01741476,
-0.019228797,
0.015535935,
0.0014901023,
0.023893464,
-0.0007681315,
-0.01946203,
0.020226518,
-0.0075282557,
0.027858432,
0.011920818,
-0.010780565,
-0.019695263,
0.025577929,
-0.019073308,
0.010800001,
0.014875107,
-0.018386565,
0.0116422335,
-0.031305104,
0.024748653,
-0.018606842,
0.00745699,
0.024955973,
-0.014006961,
-0.0018334736,
0.018205162,
-0.016442955,
0.00485255,
-0.009860589,
0.0083575295,
0.023932338,
0.008687944,
-0.0070747463,
-0.037861552,
0.024787527,
-0.044443917,
0.0221183,
0.01251038,
-0.014836235,
-0.01025579,
-0.0052769054,
-0.018788245,
-0.020680027,
0.01725927,
-0.01666323,
0.0007531495,
-0.015173128,
-0.0019322739,
-0.018036716,
0.021263111,
0.0057012606,
-0.021392684,
-0.010612119,
0.0050307144,
0.0041787648,
-0.041671034,
-0.000835753,
0.0149269365,
-0.012912059,
0.009594963,
0.009199762,
-0.014266109,
-0.02967247,
-0.0011953211,
-0.017194483,
0.0061320947,
0.0010876126,
0.012892623,
0.00920624,
0.008849911,
-0.023686146,
-0.001135393,
-0.0016172468,
0.01300924,
0.16647682,
-0.014253152,
-0.027184647,
0.007152491,
-0.0036151176,
0.0019841036,
-0.004324536,
0.0014779547,
0.00590534,
-0.005979845,
0.017272228,
0.008610199,
0.011570968,
0.005869707,
0.0012447212,
-0.017686866,
-0.02556497,
-0.008746252,
-0.016883506,
-0.01806263,
0.009245113,
-0.005170007,
0.018606842,
-0.005043672,
0.034803603,
-0.0074829045,
-0.013644153,
0.013235995,
0.011065628,
-0.012918538,
-0.03822436,
0.012387284,
0.008882305,
-0.00038811495,
-0.0036799046,
0.019656392,
-0.00077137083,
-0.016170848,
0.008500061,
-0.011169288,
0.0004032994,
0.004282424,
-0.017635036,
-0.003858069,
0.001741152,
0.036799047,
-0.0007936414,
-0.01725927,
-0.0022659271,
-0.013708941,
-0.02822124,
-0.016922379,
0.012976847,
-0.015898742,
0.015639594,
0.0048395926,
0.0046873433,
0.009283985,
-0.013566409,
0.016611401,
-0.027236477,
-0.009109059,
-0.033196885,
0.044806726,
-0.0030692867,
0.021353813,
-0.003388363,
0.009737494,
-0.004198201,
-0.018075587,
-0.0042176372,
0.007774446,
-0.019734137,
0.0019015,
-0.024955973,
-0.0046225563,
0.024450634,
0.011946732,
-0.004159329,
-0.00005491715,
0.014084705,
0.022183087,
-0.01741476,
-0.00053975714,
-0.000357746,
-0.012847273,
0.020757772,
-0.0035762454,
-0.047761016,
0.015704382,
-0.0028911221,
-0.007858669,
-0.007618957,
-0.006200121,
0.0066406727,
-0.0011953211,
0.01491398,
-0.0035017403,
0.009497782,
-0.018036716,
-0.021794364,
0.06535718,
0.033430118,
-0.012484465,
-0.013067548,
0.0145900445,
-0.007165448,
-0.004308339,
-0.004324536,
-0.0125039015,
0.0040621483,
-0.027055074,
0.027754772,
-0.0072691073,
-0.027702944,
0.01961752,
0.004917337,
-0.018256992,
0.026238756,
0.008376966,
0.004732694,
-0.033430118,
0.013294303,
0.012782485,
0.016131977,
-0.005934494,
-0.034492627,
0.021535216,
0.014356811,
-0.035451476,
0.026640436,
-0.0147455335,
-0.017272228,
0.03197889,
0.0059474516,
-0.009173847,
0.0048331143,
-0.008545413,
-0.014706661,
0.016533656,
-0.0022529697,
-0.024709782,
0.021327898,
0.004013558,
0.011182245,
-0.001516017,
0.018723458,
0.04218933,
-0.013851472,
-0.0127371345,
0.004632274,
-0.028998684,
-0.00025651624,
-0.0066341944,
0.025357652,
-0.023647275,
-0.011396043,
-0.0067637684,
0.00028830237,
-0.0066406727,
-0.011532095,
0.00054866535,
-0.0027712663,
-0.0071719266,
-0.011020278,
0.004298621,
-0.15880603,
0.002842532,
0.01666323,
-0.024994845,
0.025824118,
0.0035762454,
-0.003919617,
0.005095502,
-0.020822559,
0.01891782,
0.037446916,
0.00810486,
-0.02206647,
-0.0036928619,
0.0023355733,
0.011104501,
-0.0056170374,
0.024800483,
0.022494065,
0.011337734,
0.042759456,
-0.024904143,
0.0073079797,
-0.019151052,
0.0083057005,
0.02051158,
-0.002236773,
-0.016455911,
-0.027340136,
-0.021768449,
-0.031331018,
-0.0015370728,
0.036306664,
-0.0037446916,
0.018127417,
-0.010476067,
0.0031211162,
-0.014240194,
0.0037446916,
0.042500306,
0.04418477,
0.006044632,
0.011726457,
0.0056267553,
-0.011998562,
0.0042565092,
-0.009970727,
-0.028247155,
0.018736416,
0.0010843733,
0.016106062,
-0.011110979,
0.0104177585,
0.011376606,
0.013229516,
-0.007735574,
0.007301501,
0.004528615,
0.0077290954,
-0.0047359336,
0.017026037,
-0.002981824,
0.029516982,
-0.003922856,
0.0043990407,
-0.02386755,
0.010722257,
0.01886599,
-0.0035438517,
0.022247873,
-0.03547739,
-0.0021784646,
0.0004458159,
-0.013132336,
0.011972647,
0.016546613,
-0.016533656,
-0.0006426066,
-0.023051234,
0.013527537,
-0.014408641,
0.013397963,
-0.014317939,
-0.0040589087,
-0.02772886,
0.0024019799,
0.0065110987,
0.016896464,
-0.0075671277,
-0.0103918435,
-0.012827836,
-0.013786685,
-0.0017832636,
-0.008364009,
0.018775288,
0.044055197,
-0.010631556,
0.0058664675,
-0.011253511,
0.006686024,
0.0138126,
-0.0057401326,
-0.02241632,
0.0011734555,
-0.02356953,
0.0077679674,
-0.006498141,
-0.013916259,
0.022882788,
-0.005999281,
-0.0049626883,
0.023984168,
0.0115126595,
-0.0028506303,
-0.013294303,
0.0145123,
-0.01795897,
-0.0041658073,
-0.013683026,
-0.011804201,
0.06711939,
-0.0009118778,
-0.0072885435,
0.019202882,
-0.015535935,
-0.0379393,
-0.15600722,
-0.03451854,
0.02306419,
0.005059869,
-0.0050566294,
0.012834315,
-0.008662029,
-0.0094783455,
-0.009283985,
0.007126576,
-0.0055457717,
-0.005963648,
0.0028911221,
-0.030475829,
-0.004933534,
0.0018820639,
0.002636833,
-0.015458191,
-0.04182652,
0.041645117,
0.0022157172,
-0.0072431923,
-0.01341092,
-0.015730297,
0.010184525,
0.0036475111,
-0.021742536,
0.022247873,
0.01946203,
0.020796644,
0.003082244,
0.020550452,
0.034337137,
-0.016715059,
-0.0014317939,
0.019151052,
-0.03262676,
-0.01330726,
0.023763891,
0.000066153654,
-0.016844634,
-0.00034499104,
0.00585351,
-0.0055878833,
0.0066665877,
-0.02157409,
-0.025940737,
0.016170848,
0.026212841,
-0.027210562,
-0.0036313143,
-0.017933056,
-0.05294398,
-0.011039713,
0.00575309,
-0.014486385,
0.012704741,
0.03371518,
-0.004667907,
0.006410679,
0.0031065391,
-0.009718058,
-0.016676188,
-0.0021784646,
0.051518664,
-0.001230954,
0.002732394,
-0.021898024,
0.027262392,
-0.050818965,
0.012484465,
-0.03166791,
-0.018827118,
0.0038256755,
-0.003278225,
0.019539775,
0.0018772049,
-0.026640436,
-0.0058275955,
-0.017660951,
-0.010793523,
-0.017155612,
0.026795926,
-0.011797722,
0.05063756,
0.020796644,
0.011013799,
-0.0007976906,
0.007975286,
0.011091543,
-0.0256168,
0.034544457,
-0.008985965,
-0.010113259,
-0.0016350632,
0.014369768,
-0.005344932,
-0.010281705,
0.032186206,
0.04892718,
0.02131494,
-0.009951292,
-0.03547739,
0.013618238,
-0.009912419,
0.0018593884,
0.012400242,
-0.009996642,
0.014292024,
-0.04923816,
-0.003388363,
0.012173487,
-0.030579489,
0.0026611283,
-0.0026902824,
0.015406361,
-0.039338697,
-0.0013135575,
0.0064463117,
0.018166289,
0.015432276,
0.013929216,
0.006932215,
-0.0019630478,
-0.000022561584,
0.020187646,
0.013462749,
0.017479546,
-0.00039236658,
0.030786807,
-0.015652552,
0.016533656,
0.012879666,
-0.0107093,
-0.018399524,
0.024100784,
-0.016844634,
0.011110979,
0.017220398,
0.028739536,
0.020161731,
0.038353935,
-0.021833237,
-0.03698045,
0.010910139,
-0.023699103,
-0.0029186567,
-0.03542556,
-0.03156425,
0.012290104,
-0.0053254957,
-0.023154892,
0.039546017,
0.0128084,
-0.0096079195,
-0.04182652,
-0.012270668,
0.022766171,
0.019293584,
-0.014188364,
-0.018282907,
-0.033248715,
0.011493223,
0.015872829,
0.01795897,
0.022856873,
0.0059539303,
-0.04939365,
-0.034259394,
0.023193765,
0.021833237,
-0.0037220162,
-0.0050177574,
0.013002762,
0.011875466,
-0.0043504504,
0.0044573494,
0.0024943014,
0.00045027002,
0.006034914,
-0.01631338,
0.015510021,
0.013054591,
0.0045156577,
-0.014201322,
0.021807322,
0.054006487,
0.008823996,
-0.0075088195,
0.025331737,
-0.012115179,
-0.0072431923,
0.014836235,
0.012957411,
0.010003121,
0.010825916,
0.010540853,
0.017803483,
0.017207442,
0.02671818,
0.015212,
0.02517625,
0.023634316,
-0.008830476,
0.009439474,
-0.025189206,
0.004356929,
0.0048655076,
-0.046802167,
-0.033689268,
-0.021340854,
0.029542895,
0.012866708,
0.022377448,
0.0031405524,
-0.010787045,
-0.047683273,
0.030501744,
0.00075072,
0.010242833,
-0.019215839,
0.030553574,
0.011421957,
0.012199402,
-6.9595467e-7,
-0.01306107,
-0.0059280153,
0.010534375,
0.022183087,
-0.022092385,
0.008888784,
0.012788964,
0.006990523,
0.0125816455,
-0.028739536,
-0.008163169,
-0.03594386,
-0.027055074,
0.029439237,
0.017116738,
-0.010890704,
0.06058885,
0.0057045,
-0.020252433,
0.0053643677,
-0.012646433,
0.00600576,
0.016533656,
0.02596665,
-0.0036928619,
-0.008843433,
0.038353935,
0.013268389,
0.029879788,
-0.027288307,
-0.01626155,
0.02456725,
-0.008292743,
0.007081225,
0.008130775,
-0.009815238,
0.0019079787,
-0.02042088,
0.013320218,
-0.0057466114,
-0.024489505,
0.0028797844,
0.029413322,
-0.015885785,
-0.003156749,
-0.03661764,
0.017647993,
0.004758609,
-0.034388967,
-0.011098022,
-0.0033494907,
-0.027106903,
-0.02967247,
-0.043899707,
-0.010378886,
0.014551172,
0.012167009,
0.010022557,
-0.023180807,
-0.022196043,
-0.019073308,
-0.0042791846,
-0.032393526,
-0.020628197,
-0.003981164
] |
Objectives: To study the change in outcome for patients admitted to an intensive care unit following the establishment of a team of resident medical staff and a change from an "open" to a "closed" organisational format. Design: Database review of prospectively collected data. Setting: Intensive care unit of a postgraduate teaching hospital. Subjects: 1134 admissions to the intensive care unit over a 3-year period, of whom 476 (42%) followed elective surgery. Main outcome measure: Hospital mortality corrected for illness severity by using the APACHE II scoring system. Results: Crude hospital mortality fell from 28% before the | [
0.009825918,
-0.010486426,
0.007817154,
-0.03513634,
0.011160553,
0.029144093,
0.017799687,
0.039249197,
-0.022348344,
-0.00015161482,
-0.010357048,
0.030969003,
0.020727715,
0.005661989,
-0.014817184,
-0.0076945852,
0.036307547,
0.0034234095,
-0.009771443,
-0.009737396,
-0.04025698,
0.014231578,
-0.027591558,
0.009179028,
-0.00904284,
-0.015171271,
0.0025994761,
-0.027809458,
-0.0005885847,
-0.012079818,
0.018099299,
-0.003122095,
-0.013332741,
-0.004490778,
-0.022525389,
-0.011889156,
-0.0012878217,
0.0033399947,
0.02346508,
-0.0065199696,
0.028245257,
0.0018844925,
-0.003047192,
0.0066118957,
0.00425245,
0.0114125,
0.021476746,
-0.019216035,
-0.026611008,
0.023396987,
0.016819138,
0.019828878,
-0.0047086775,
0.01012553,
0.005828819,
-0.014817184,
0.005454303,
-0.0006371015,
0.002304971,
-0.0060773604,
0.012726708,
-0.0071566454,
-0.014149866,
0.015988395,
-0.010084674,
0.0038711254,
-0.007783107,
0.012937798,
0.025671316,
0.02001954,
0.054502178,
0.030070167,
0.005736892,
0.0020785595,
0.02045534,
-0.0017636262,
-0.014694615,
-0.009008793,
0.01323741,
0.018140156,
0.0037826037,
-0.015702402,
-0.007953341,
0.0096488735,
0.015620689,
-0.01205939,
-0.0034829916,
0.029988455,
0.010527282,
0.018317198,
-0.003993694,
0.022784144,
0.02669272,
0.017976731,
-0.014680997,
0.010670279,
-0.017895019,
0.020114873,
0.029253043,
-0.014953371,
-0.009076887,
-0.013380407,
-0.025371704,
-0.017840544,
-0.0013261243,
0.015321077,
0.0033808511,
-0.015906682,
0.019992303,
-0.0078103445,
-0.018970897,
0.042054653,
-0.008416378,
-0.010323001,
0.026093496,
-0.013257839,
-0.0007234953,
0.0011167363,
-0.0067480835,
-0.024718005,
0.022702431,
0.010942654,
0.031486515,
-0.022280252,
0.008191669,
-0.00036770586,
-0.0119640585,
-0.016315244,
0.0037077006,
-0.014898896,
-0.011146935,
0.007115789,
0.036879536,
0.027618796,
0.0055087786,
0.02865382,
-0.0031084763,
0.0032531754,
-0.021694645,
-0.04436984,
-0.000838829,
-0.0032429614,
0.0074766856,
-0.025467034,
-0.011344407,
0.0019100276,
0.030478729,
0.017500075,
0.0014146462,
0.007333689,
0.0085049,
-0.0476111,
-0.020537052,
0.01152145,
0.024745243,
0.002733961,
0.007987388,
0.028054595,
-0.027795838,
-0.028762769,
-0.018467005,
-0.007912485,
-0.011187791,
0.010942654,
0.016110964,
0.004650798,
0.018426148,
0.0055087786,
0.012958227,
0.011752969,
-0.0088385595,
0.013067177,
-0.021408651,
0.01735027,
0.026869765,
0.013693638,
-0.0018878971,
0.031704415,
-0.032603253,
-0.031268615,
-0.043906804,
0.016669331,
0.017867781,
0.02466353,
-0.019542886,
-0.005910531,
0.027360039,
0.0340196,
0.014258816,
0.002723747,
0.024336679,
0.011569115,
-0.019692691,
0.010969891,
-0.6550067,
-0.019461172,
0.0115078315,
-0.012284099,
0.019406697,
0.024254967,
0.014286053,
-0.009063268,
-0.015375552,
0.004844865,
0.0045384434,
0.016546763,
0.03502739,
-0.011895965,
-0.009001984,
-0.022266632,
0.010139149,
0.00087159907,
0.0075175418,
-0.033311427,
0.0028769579,
0.02767327,
0.00325658,
0.0030063358,
-0.011923202,
0.022470914,
0.037860084,
-0.024690768,
-0.004511206,
-0.0078852475,
-0.015225746,
0.018262723,
0.02056429,
-0.011752969,
0.044887353,
-0.0063054743,
-0.006870652,
0.00022087886,
-0.0028395064,
0.016233532,
-0.0045963232,
-0.007939722,
0.009390118,
-0.007762679,
-0.019025372,
-0.0033059479,
-0.004364805,
-0.012508809,
0.009962105,
-0.013230601,
0.004276283,
-0.0074971137,
-0.0053147115,
0.0041400953,
0.005372591,
-0.0062918556,
0.0234787,
-0.014953371,
0.014490334,
0.010949463,
-0.0053147115,
-0.020319153,
-0.03960328,
-0.024731623,
0.001418902,
0.003789413,
0.016628476,
-0.0076060635,
0.007905676,
-0.006829796,
0.0024956332,
0.0057028453,
0.0003574918,
0.01485804,
0.030206354,
0.018453386,
0.01378216,
0.016492289,
0.00091585994,
-0.0009975723,
0.013904729,
0.00045495087,
-0.007599254,
0.0029671818,
0.005083193,
0.016928088,
-0.011208219,
-0.009213074,
-0.004078811,
-0.01713237,
-0.0100982925,
0.01937946,
0.0035238478,
-0.009022412,
3.2916375e-7,
0.032576013,
-0.0073268795,
0.0014538,
0.03088729,
-0.033747226,
-0.028735531,
-0.0051751193,
0.0056687985,
0.006169287,
0.009832727,
0.011773396,
0.0035238478,
-0.006016076,
0.06444386,
-0.017758831,
-0.009553542,
-0.015811352,
0.0012324955,
-0.009914439,
0.021122659,
-0.033338662,
0.011249076,
0.020618765,
-0.020809427,
-0.021926163,
0.03369275,
0.00028301435,
0.022348344,
-0.00393241,
0.019406697,
0.014517572,
0.0003047192,
-0.017091513,
-0.027319184,
-0.013073985,
0.028463157,
-0.011446547,
0.03543595,
-0.010241289,
0.024323061,
0.005287474,
0.005515588,
-0.019624598,
0.0025603222,
-0.02153122,
-0.021286083,
-0.02335613,
0.01756817,
-0.010888179,
-0.0076401103,
-0.027332801,
0.0030591085,
0.0051512867,
0.014544809,
-0.0012044068,
-0.0030812388,
-0.017404744,
-0.003520443,
-0.0058083907,
0.00489934,
-0.014122629,
-0.01699618,
-0.019243272,
-0.018221868,
-0.027482608,
0.012801611,
0.027360039,
-0.03154099,
-0.005028718,
-0.013312314,
-0.013530213,
-0.017037038,
0.00710898,
-0.009941677,
-0.03524529,
0.015225746,
-0.0027714127,
-0.0010511961,
0.00046686726,
-0.014163485,
-0.003952838,
-0.028027358,
-0.017867781,
0.003111881,
-0.0075311605,
0.01464014,
0.018003969,
-0.0032787104,
0.004330758,
0.011970868,
0.0004953815,
0.00001054654,
0.0065403976,
-0.010649851,
0.01916156,
0.012801611,
0.0021381415,
0.011793825,
0.023546793,
-0.005610919,
0.011984487,
0.0004770813,
-0.008647897,
-0.0034591588,
-0.0032276402,
0.035681088,
0.0077013946,
0.04112858,
-0.0068332003,
0.012794802,
0.0015653034,
0.031159665,
-0.0073677357,
0.025889216,
-0.013094414,
-0.004381828,
0.00022236841,
0.0174456,
-0.010077864,
-0.013680019,
0.030832816,
0.0070136487,
0.007851201,
-0.017077895,
0.014572047,
0.0031289044,
0.0016946814,
0.024391156,
0.014408622,
-0.01830358,
-0.024391156,
0.021898925,
0.006319093,
0.018058443,
0.0066050864,
-0.011998106,
0.006751488,
0.024432011,
0.003500015,
0.032848388,
0.022048732,
-0.00162829,
-0.00613524,
0.0335838,
0.0058969124,
0.0042149983,
0.022579864,
0.010084674,
-0.015634308,
-0.00008463831,
-0.013530213,
0.019760786,
0.022647956,
-0.028490394,
0.00032621127,
0.0027254494,
-0.0013976227,
-0.0096965395,
0.0038064364,
0.0067140367,
0.0044499217,
0.007354117,
-0.00016044572,
0.030805578,
0.02014211,
-0.00034451144,
0.005341949,
0.004262664,
0.0017602216,
-0.01604287,
0.015157652,
-0.008913462,
-0.0015108284,
0.0046882494,
-0.020400865,
-0.020646002,
-0.0002521594,
0.0035817274,
0.008212097,
0.014667378,
0.0096965395,
-0.0025637269,
0.005382805,
0.012965036,
0.011705303,
0.014898896,
-0.006955769,
0.017622644,
0.017159607,
-0.0020496196,
-0.004589514,
0.0066902037,
0.014354147,
-0.0055189924,
0.026175208,
-0.02218492,
-0.016655713,
-0.006850224,
0.00069923693,
0.0058526513,
0.0021109038,
0.01699618,
-0.034046836,
0.0043001156,
-0.016070107,
-0.017881399,
-0.011970868,
-0.015893064,
-0.03410131,
0.016778281,
0.00007277512,
-0.007674157,
-0.014095391,
-0.032957338,
-0.012747136,
-0.018780235,
-0.008552566,
-0.022702431,
0.0045180153,
0.009601208,
-0.020060398,
-0.030533204,
0.0023985996,
0.038813394,
-0.0032446636,
-0.007687776,
-0.00516831,
0.009533115,
-0.009996152,
0.064661756,
0.03015188,
0.0143813845,
0.024309441,
-0.0007341349,
-0.01335317,
-0.027591558,
-0.017704356,
-0.0035306572,
0.016751043,
-0.012570092,
0.017472837,
0.021326939,
0.005338544,
0.014735471,
0.016764663,
0.012447524,
-0.014572047,
0.001692979,
-0.005621133,
0.0034114933,
0.007258786,
0.014354147,
0.02810907,
0.013605117,
-0.017935874,
0.018807473,
0.015688783,
-0.006805963,
-0.021040946,
-0.011807444,
0.024050687,
-0.0065710396,
0.013087604,
-0.0023764693,
0.0037315334,
0.022021495,
-0.008525328,
0.03219469,
-0.000040483817,
-0.007980579,
0.016192676,
-0.0028990882,
-0.018916423,
0.018930042,
-0.006298665,
0.015416408,
0.029225806,
-0.0029552656,
-0.02542618,
0.018603193,
0.0004545253,
-0.02745537,
-0.018276343,
0.024200492,
0.0148852775,
0.0007703097,
-0.011603163,
-0.0026352252,
0.005590491,
-0.02832697,
-0.026284158,
0.020918377,
-0.011548688,
-0.032848388,
-0.024282204,
-0.03015188,
0.007708204,
-0.0348912,
-0.011378453,
0.023996212,
-0.03377446,
-0.03388341,
0.019365842,
0.00059411733,
-0.0032208308,
0.024146017,
-0.013039939,
0.010064245,
0.0060092667,
-0.022361964,
0.010636232,
-0.00023875345,
-0.016723806,
0.004643989,
-0.0040754066,
-0.0134757385,
-0.023437843,
-0.021040946,
0.026120733,
-0.007449448,
-0.00025875596,
-0.0018283152,
0.02057791,
-0.007871629,
0.0045043966,
0.0019236463,
-0.010888179,
-0.015416408,
-0.03459159,
0.016655713,
-0.02142227,
-0.0077967257,
-0.011787015,
0.01000977,
-0.0011635507,
-0.024432011,
0.014231578,
0.016233532,
-0.024186874,
0.03230364,
-0.020169348,
-0.0005383656,
-0.009948486,
0.015784115,
0.006339521,
-0.0029195163,
0.02488143,
0.03186784,
-0.013788969,
0.009859964,
0.016832756,
0.009614827,
0.0045963232,
-0.016383339,
0.0085049,
-0.0057777483,
-0.025112947,
-0.050906833,
-0.023396987,
-0.023328893,
0.013394026,
0.017908636,
-0.02800012,
-0.023778312,
-0.007926104,
0.0018981112,
0.01873938,
-0.008028245,
-0.014408622,
-0.010329811,
-0.008661516,
-0.007408592,
-0.012570092,
0.014435859,
-0.028572107,
-0.0076196822,
0.0027220447,
0.011426119,
0.008246144,
-0.011501022,
-0.0145311905,
-0.016723806,
-0.0023185897,
-0.020373628,
-0.046004087,
-0.017268557,
-0.0011184387,
0.02658377,
0.021326939,
0.024636293,
-0.010561329,
0.0236966,
0.005004885,
-0.0011780206,
0.00968973,
0.008695562,
-0.007034077,
0.0024854192,
0.029552655,
0.013448501,
0.00064901786,
0.007238358,
0.0042184032,
0.0111537445,
0.016819138,
0.0044703498,
-0.03459159,
-0.013802588,
-0.04336205,
-0.022961188,
-0.0011235457,
-0.0065948726,
-0.008130385,
-0.048564408,
-0.0048210323,
0.018793855,
0.0008524477,
0.0038404833,
0.0025620246,
0.015893064,
-0.008055482,
-0.017935874,
-0.019665454,
-0.00040558295,
-0.022920331,
-0.0019083252,
-0.027210234,
-0.016928088,
0.0138774915,
0.0039221956,
0.019774403,
0.019828878,
-0.013203364,
-0.008123576,
0.017690737,
-0.011310359,
0.0011924905,
0.002276031,
-0.009437784,
-0.0027918408,
-0.013482548,
0.0034387307,
-0.003479587,
-0.002434349,
0.0234787,
0.007163455,
0.021667408,
-0.014095391,
0.00861385,
0.0012673936,
-0.030124642,
0.02832697,
0.0052772597,
0.02025106,
0.030124642,
-0.0041400953,
-0.0063667586,
0.007238358,
0.005209166,
0.009185837,
0.019461172,
0.028681057,
-0.015307458,
0.0032327473,
-0.003724724,
0.024173254,
-0.014871659,
-0.015443645,
0.006438257,
0.017840544,
-0.014544809,
-0.032276403,
-0.0063054743,
-0.03015188,
0.0172277,
0.00656423,
-0.027074046,
0.025548747,
-0.02636587,
-0.0043954467,
0.013863873,
-0.023737455,
0.030179117,
0.021217989,
0.00043622512,
0.00732007,
-0.034210265,
-0.021122659,
0.02208959,
-0.023219943,
0.013768542,
-0.017214082,
-0.006053528,
0.021490363,
0.021572076,
0.0027220447,
-0.0008354243,
-0.04360719,
0.030560441,
-0.0022334727,
-0.011330788,
0.016369719,
0.0032395567,
-0.009492259,
-0.042681117,
-0.0045929183,
-0.012610949,
-0.006036504,
0.005447494,
-0.0053862096,
0.025276372,
-0.015811352,
-0.009567161,
-0.0114125,
-0.0006243339,
0.017200463,
-0.018262723,
-0.0012682447,
-0.014844421,
-0.015811352,
0.0068229865,
-0.012134293,
-0.010643042,
-0.010057436,
-0.01571602,
-0.0067651067,
0.01863043,
-0.037614945,
0.010282145,
0.0058526513,
-0.009417355,
-0.025480654,
0.018426148,
-0.022811381,
0.0019304557,
0.04273559,
-0.004929982,
-0.015157652,
0.0009771442,
0.0051819286,
0.028054595,
-0.017949494,
-0.00017544761,
0.0036906772,
0.020972852,
-0.006247595,
0.008899843,
-0.01260414,
0.027087664,
-0.023560412,
0.0074154013,
0.016465051,
-0.018358056,
0.014190722,
-0.004044764,
0.03230364,
-0.007728632,
-0.03668887,
-0.0061863107,
-0.0141771035,
0.016315244,
-0.035626613,
0.00045239736,
-0.014844421,
-0.012631377,
-0.017717974,
0.019120704,
0.021367796,
-0.0013337849,
-0.015007846,
-0.026515678,
-0.015212127,
0.014544809,
0.0053759958,
-0.01184149,
0.012481571,
0.0022147468,
-0.027577939,
-0.0031799746,
-0.035735562,
0.033638276,
0.015103177,
-0.022784144,
-0.018807473,
-0.0067276554,
-0.05363058,
0.010649851,
-0.013938775,
0.03164994,
0.020169348,
0.00018981112,
0.010663469,
0.0131216515,
0.0049572196,
0.0043784236,
-0.03693401,
-0.014572047,
0.011446547,
-0.008920272,
0.020319153,
-0.014122629,
-0.044451553,
0.011473784,
0.010411523,
0.015988395,
-0.0024190277,
0.023437843,
0.019665454,
-0.014272435,
0.011167363,
-0.0013193149,
-0.020319153,
0.0027543893,
-0.0025671315,
-0.031159665,
-0.004426089,
0.02229387,
-0.007558398,
0.01034343,
0.007115789,
0.009642065,
0.027305564,
0.015552595,
-0.004024336,
-0.005995648,
0.015157652,
-0.017840544,
0.018712142,
0.0020649408,
0.0061080027,
0.018072061,
0.019202417,
-0.009839537,
-0.012004915,
0.01270628,
-0.02012849,
-0.018548718,
0.00710898,
-0.004865293,
-0.019461172,
-0.0010563032,
0.012999083,
-0.019393079,
-0.01841253,
-0.0056347516,
0.0007073231,
0.0091926465,
-0.0012010022,
-0.0065165646,
-0.023533175,
0.010929035,
-0.00635314,
-0.015293839,
-0.0041400953,
-0.02251177,
0.006189715,
-0.011330788,
-0.010622613,
-0.012638186,
-0.014585665,
0.01917518,
0.013823017,
-0.0067242505,
-0.0060671465,
0.01098351,
0.19687244,
-0.014463097,
-0.02185807,
0.012787992,
-0.032358114,
-0.0061420496,
0.006502946,
0.0029705865,
-0.01271309,
0.027251089,
0.0012418585,
0.005774344,
-0.004531634,
0.0009379904,
0.01808568,
-0.0019100276,
-0.02196702,
-0.021994257,
-0.005716464,
0.02142227,
0.011684875,
-0.0012929287,
0.013693638,
0.01582497,
0.020278297,
0.007354117,
-0.0032889245,
0.015402789,
0.033229712,
0.016342482,
-0.0011958951,
-0.014449478,
-0.0003547255,
0.02023744,
0.003986885,
-0.013564261,
-0.0051819286,
-0.01690085,
0.012256862,
-0.010833704,
-0.010513663,
0.0020530242,
0.012563284,
-0.010486426,
0.010384286,
0.027387276,
-0.002653951,
-0.0014410324,
-0.009049649,
0.0004834651,
-0.020046778,
-0.004831246,
0.012508809,
-0.011126507,
0.0015610475,
0.0070068394,
0.025480654,
0.0096488735,
0.0026931048,
-0.021395033,
0.006771916,
-0.0031527372,
-0.01571602,
0.009887202,
-0.004385233,
0.01916156,
-0.03175889,
0.0067991535,
-0.013148889,
-0.016301626,
0.006965983,
-0.02541256,
-0.018031206,
-0.0051649055,
-0.017186845,
-0.03211298,
0.022334727,
0.033556562,
0.010309382,
0.022048732,
-0.012324955,
-0.02023744,
-0.017758831,
0.004249045,
-0.01324422,
-0.038786158,
0.027591558,
0.013795779,
-0.015511739,
-0.0030625132,
-0.00046346258,
-0.014463097,
-0.016328864,
-0.008123576,
0.015157652,
0.01593392,
0.01152145,
0.00452142,
-0.009390118,
-0.0063054743,
-0.010220861,
0.07054505,
0.010037008,
-0.010377476,
-0.006094384,
0.00018151221,
-0.017500075,
0.033202477,
0.024200492,
-0.012079818,
0.014558428,
-0.0004575044,
-0.0005996499,
-0.008743228,
0.01464014,
0.03480949,
0.0107519915,
-0.008695562,
0.014013679,
-0.018426148,
0.003370637,
-0.002022382,
0.0063088792,
0.0143813845,
-0.0075515886,
-0.0030454895,
-0.020196585,
-0.0010511961,
-0.015920302,
-0.02001954,
0.004112858,
-0.022661576,
0.0012452631,
0.0019049206,
-0.006356545,
0.016587619,
0.011746159,
-0.023764692,
-0.0013942181,
0.031704415,
-0.005284069,
-0.0051070256,
0.0016895743,
-0.010329811,
0.020046778,
-0.01432691,
0.02444563,
0.01023448,
-0.019542886,
-0.0058015813,
0.0033774464,
-0.010152767,
0.00872961,
-0.012570092,
0.032167453,
-0.02594369,
0.0038132458,
-0.015007846,
0.014994227,
0.0012035557,
-0.019297747,
-0.000686895,
0.016587619,
-0.0105545195,
-0.009539924,
-0.0036021555,
-0.1743198,
0.018916423,
0.02184445,
0.007946532,
0.058506086,
-0.0018964089,
0.013605117,
0.017949494,
-0.0062203575,
-0.012999083,
-0.0077899164,
0.011541878,
-0.04047488,
-0.013203364,
0.010295764,
0.024949523,
-0.021381414,
0.029988455,
0.014953371,
0.013312314,
0.026175208,
0.002778222,
0.00088436663,
-0.009499067,
0.017908636,
0.0141771035,
-0.0014274137,
0.020768572,
-0.0076605384,
-0.010282145,
-0.02682891,
-0.011112888,
0.033638276,
-0.003619179,
-0.022879476,
-0.001607862,
0.00019417338,
0.015661545,
-0.014136247,
0.019869735,
0.010595376,
0.024622673,
-0.013496167,
0.000061922685,
-0.023723837,
0.008743228,
0.0344554,
0.021912545,
0.028054595,
-0.0036804632,
-0.0065335883,
-0.019202417,
0.005740297,
-0.0006954067,
-0.0055938954,
-0.0032684964,
-0.00753797,
0.009744205,
-0.0065914677,
0.0029790984,
-0.00732007,
-0.030097404,
0.00325658,
0.028245257,
-0.008157622,
-0.049599435,
0.017854162,
-0.0009541626,
-0.012209197,
0.015893064,
-0.044751164,
0.015620689,
0.012835658,
0.0025058473,
0.026093496,
0.019978685,
-0.022307489,
0.0067038224,
0.011010747,
-0.0110039385,
0.0029910146,
0.022035114,
-0.029879505,
-0.011793825,
-0.0014427347,
-0.00010730074,
0.002325399,
0.0045418483,
-0.0029552656,
-0.008750037,
0.009716967,
-0.036089648,
-0.003952838,
-0.012202387,
0.0030744295,
0.031268615,
-0.025112947,
-0.015784115,
0.013434882,
-0.031813364,
0.014762709,
0.0140272975,
-0.016642094,
0.001509126,
0.005719869,
0.009635255,
-0.017173225,
-0.00904284,
0.048755072,
-0.004364805,
-0.012924179,
0.015593451,
0.01044557,
0.006979602,
-0.009076887,
0.020918377,
0.0008532989,
-0.015647927,
-0.0174456,
-0.03110519,
0.044996303,
-0.0046371794,
-0.020400865,
0.0014257113,
-0.00007479665,
-0.032385353,
-0.12790716,
-0.009832727,
0.020959234,
0.014926134,
-0.0046473932,
0.015375552,
-0.01572964,
-0.003479587,
-0.02001954,
0.02185807,
-0.010854132,
-0.028299732,
-0.030914528,
-0.0009848048,
0.033502087,
0.0025807503,
0.00095331145,
-0.030179117,
0.019147942,
0.028626582,
0.013945585,
-0.0028803626,
0.022947568,
-0.008858987,
0.014095391,
-0.016560381,
-0.02637949,
0.030614916,
0.008205288,
0.022607101,
0.019679073,
-0.0066833943,
-0.0068536284,
-0.014122629,
-0.01830358,
-0.019883353,
-0.010711135,
-0.004831246,
0.039439857,
-0.04003908,
0.0040754066,
-0.013618736,
0.008927081,
-0.0123658115,
0.013033129,
0.0062714275,
-0.03143204,
0.0051512867,
-0.011473784,
-0.025848359,
-0.008457234,
-0.02488143,
-0.0052772597,
-0.010268526,
0.015661545,
-0.021136276,
0.039548807,
0.009172218,
-0.018780235,
0.007333689,
-0.013857063,
0.026910622,
-0.032548778,
0.035327,
0.019542886,
-0.01850786,
-0.019502029,
-0.009131362,
-0.006656157,
-0.009492259,
-0.011112888,
0.021122659,
-0.02313823,
-0.010329811,
-0.034509875,
-0.026107116,
-0.032766677,
-0.009219884,
-0.00019481176,
-0.0155389765,
-0.011691684,
-0.015293839,
0.022443676,
-0.020414485,
-0.00065114576,
0.016015632,
0.0031101787,
-0.020305535,
0.009737396,
0.0140272975,
0.02358765,
0.01755455,
-0.011494213,
-0.018112918,
0.018984517,
0.004878912,
0.0052568316,
-0.04101963,
-0.028190782,
0.004987862,
-0.018153774,
-0.0018878971,
-0.053031355,
0.01507594,
-0.0080350535,
-0.026243303,
0.0022096399,
0.0010435355,
0.011712112,
0.01087456,
0.007388164,
0.01927051,
-0.044778403,
0.017295795,
-0.019965066,
0.0072315484,
-0.023546793,
-0.011569115,
0.013196554,
0.030342542,
0.011664446,
0.017595407,
-0.019188797,
-0.019433934,
0.005621133,
0.007074933,
0.004661012,
-0.009539924,
0.0217355,
0.017105132,
-0.0046133464,
-0.018807473,
0.012420286,
-0.0007703097,
-0.003215724,
0.018562336,
0.016519526,
-0.020904759,
0.0038268645,
0.02346508,
0.014871659,
0.010207242,
-0.022607101,
-0.034210265,
0.0044124704,
-0.018426148,
-0.009396927,
0.0072928327,
-0.029198568,
0.024636293,
-0.028980669,
-0.016315244,
0.021163514,
0.012849277,
-0.023056518,
-0.018439768,
-0.0013669805,
0.0038881488,
0.0038404833,
0.020046778,
-0.013053558,
-0.009185837,
0.021381414,
-0.028735531,
0.0030795366,
0.004844865,
0.03366551,
-0.008409569,
-0.019134322,
0.004276283,
0.000060539533,
-0.015430027,
-0.015784115,
-0.014095391,
-0.0054304707,
0.02519466,
-0.0043205437,
-0.00023364642,
0.00070689747,
0.029743318,
0.00057837064,
0.025276372,
0.007953341,
-0.0013133568,
-0.018044824,
-0.00022534751,
0.03824141,
0.016628476,
0.0014759304,
0.028081832,
-0.008007816,
0.0064008054,
-0.0012852681,
0.014286053,
-0.022743288,
0.010472807,
-0.0020189774,
0.010309382,
0.014544809,
-0.011044795,
0.022266632,
0.015021465,
0.0018998135,
0.018140156,
-0.0143813845,
-0.032712203,
-0.02669272,
-0.018562336,
-0.0048618885,
-0.061938006,
-0.018317198,
0.022756906,
0.003076132,
0.0067582973,
0.019556504,
0.014449478,
-0.024472868,
-0.0041707377,
0.003854102,
-0.007224739,
-0.012188768,
0.0065301834,
-0.013230601,
0.012168339,
-0.004153714,
0.0046780356,
0.013325932,
-0.00022683706,
0.029525418,
-0.028953431,
0.025889216,
-0.005665394,
-0.0012469655,
0.0153891705,
-0.018153774,
-0.03167718,
0.015334696,
-0.013652782,
0.0065369927,
-0.003768985,
0.011323978,
0.06722207,
0.009083697,
-0.019937828,
-0.0035306572,
-0.012025343,
0.0010367262,
0.006053528,
0.01421796,
0.010037008,
-0.022253014,
0.0062544043,
-0.009894012,
-0.0024564795,
-0.032766677,
0.0018589573,
-0.010043818,
-0.00077243766,
0.024949523,
0.026338633,
-0.008409569,
-0.022825,
0.006159073,
0.0044873734,
0.006904699,
-0.036961246,
-0.008981556,
0.003864316,
-0.00007309431,
-0.014040916,
-0.023710217,
0.0010784336,
0.012052581,
-0.035926223,
-0.016301626,
0.0075720167,
0.0029348375,
-0.018535098,
-0.03821417,
0.022647956,
-0.0024581817,
-0.007898866,
0.014898896,
-0.038922343,
-0.031486515,
-0.036225837,
-0.027087664,
0.0077013946,
-0.0170098,
-0.03175889
] |
Tafamidis is a transthyretin (TTR) stabilizer able to prevent TTR tetramer dissociation. There have been a few encouraging studies on Tafamidis efficacy in early-onset inherited transthyretin amyloidosis (ATTR) due to Val30Met mutation. However, less is known about its efficacy in later disease stages and in non-Val30Met mutations. We performed a multi-center observational study on symptomatic ATTR patients prescribed to receive Tafamidis. We followed up patients according to a standardized protocol including general medical, cardiological and neurological assessments at baseline and every 6 | [
-0.034871113,
-0.014145577,
0.025986837,
-0.029756328,
-0.011601505,
0.038041215,
-0.03511087,
-0.0055310274,
-0.012260833,
0.008664499,
0.012667085,
0.0067997337,
0.037481785,
-0.009110711,
-0.00067223125,
-0.0012587167,
0.024415107,
0.013013398,
-0.016676331,
-0.013719345,
0.003955967,
0.013639427,
-0.023522682,
-0.0049949074,
-0.0055177077,
0.021178408,
0.015930424,
-0.045526914,
-0.023469405,
-0.018407898,
0.0005406987,
-0.0038627284,
-0.018154822,
-0.031594455,
0.0062902533,
-0.017328998,
0.013745985,
-0.0011912854,
0.023509363,
-0.019686595,
0.020858733,
0.025747081,
0.004891679,
0.012480608,
-0.015530832,
-0.0035064248,
0.0051880437,
-0.010402727,
-0.015730629,
0.035164148,
-0.0047251824,
0.020805454,
-0.03495103,
-0.02317637,
0.008251587,
-0.00809175,
0.010282849,
0.03497767,
-0.007492361,
-0.027158976,
-0.016916087,
-0.009230589,
-0.023269609,
0.013079997,
0.01887409,
-0.0040125754,
0.010915537,
-0.0033848821,
-0.0013769295,
0.017462196,
0.033698976,
0.029170258,
-0.008777717,
-0.023948915,
0.03447152,
-0.011155293,
-0.0021145109,
0.004688553,
-0.020539058,
0.010802319,
0.01831466,
-0.007052809,
-0.017022643,
0.005111455,
0.024095433,
0.014598449,
0.00069137843,
0.02480138,
-0.0032433597,
0.017315678,
0.023043172,
0.031994045,
-0.0062902533,
0.018767532,
0.00806511,
0.006892972,
-0.006300243,
0.015557471,
-0.01672961,
-0.0066565466,
-0.008378125,
-0.0034431561,
-0.000754231,
-0.002650631,
-0.02314973,
0.0024708142,
-0.002590692,
-0.005501058,
0.0005964752,
-0.037614983,
-0.027265534,
0.045020763,
-0.0023659212,
-0.01345295,
0.0038926976,
0.012740344,
0.031594455,
0.0005061506,
0.0103694275,
-0.00806511,
0.016489854,
0.016023662,
0.011228551,
-0.009197289,
-0.009397086,
0.00088576355,
-0.033112906,
-0.008877615,
-0.004645264,
0.0000028372765,
0.014665048,
0.016649691,
0.03172765,
0.00038252666,
-0.039053515,
0.0019047246,
-0.026639506,
0.0050681657,
-0.005031537,
-0.022816736,
0.004485427,
0.020206064,
-0.012800283,
-0.01668965,
-0.014158897,
0.030182559,
0.010715741,
0.023029853,
0.01567735,
0.001560076,
0.007039489,
-0.0072392854,
-0.025267571,
-0.008531301,
0.00013756807,
-0.0057508033,
-0.014225496,
0.0063202227,
-0.042276897,
-0.0041158036,
0.0029003762,
-0.00645342,
0.0097101,
0.00915733,
0.017075922,
0.020525739,
0.008358145,
-0.015477553,
0.0033099586,
-0.012740344,
-0.009916556,
0.019167123,
-0.019699914,
0.0033782222,
-0.02421531,
-0.0023009873,
-0.0005073993,
0.0024375147,
-0.03228708,
0.0032117253,
-0.014411973,
0.024122072,
0.03231372,
0.005820732,
-0.02261694,
0.010715741,
0.0023925605,
0.031514537,
0.008118389,
-0.03231372,
0.004045875,
0.015970383,
0.018807491,
-0.014265455,
-0.6436105,
-0.006250294,
0.016969364,
-0.019113844,
0.006353522,
0.013033378,
0.026652826,
0.009536943,
-0.025027815,
0.027625168,
0.0037728199,
0.030875187,
-0.00017846387,
-0.01887409,
-0.0066099274,
-0.030528873,
-0.020778814,
-0.027305493,
0.019633316,
0.005164734,
-0.010562564,
0.041078117,
-0.0013977416,
0.0066498867,
0.031088304,
-0.00269392,
0.005963919,
-0.010649142,
-0.019540077,
0.03178093,
-0.013652747,
0.017328998,
0.006626577,
-0.0063368725,
0.04909661,
-0.024028834,
0.0045020767,
0.024654862,
0.015171198,
0.022976574,
0.010962157,
0.0062902533,
0.022417143,
-0.0065999376,
-0.0037994594,
0.01995299,
-0.0015018021,
0.008198308,
0.012127635,
-0.0038660583,
-0.012467288,
-0.005431129,
-0.031541176,
-0.019580036,
0.02534749,
0.0031934108,
0.02687926,
-0.015850505,
0.01570399,
0.0139591005,
-0.013359712,
0.017622033,
-0.0049782577,
0.008837656,
-0.017542114,
-0.02257698,
0.007106088,
0.024534985,
-0.00035526277,
-0.010016454,
0.0182747,
0.036176447,
-0.0150912795,
0.009303847,
0.03231372,
0.032606754,
0.005178054,
0.013606127,
0.013366372,
0.021990912,
0.0069595706,
0.014212176,
-0.004242341,
-0.004219032,
0.018461177,
0.016862808,
-0.020912012,
0.022510381,
-0.0034265064,
0.00322671,
0.021338243,
0.006773094,
0.0036329625,
-0.03716211,
-0.008950874,
0.027012458,
0.00092905277,
0.013139936,
0.022004232,
-0.009623521,
-0.014958083,
0.0010813974,
0.016063621,
-0.013033378,
0.005547677,
-0.02048578,
-0.043875266,
0.015157878,
0.036283005,
-0.011461647,
-0.009110711,
-0.008711118,
-0.012780303,
-0.028797306,
0.011161953,
-0.030582152,
0.0042723105,
0.0015425938,
-0.0029037062,
-0.03218052,
0.017435556,
0.0021411502,
0.027172295,
0.02578704,
-0.0041957223,
0.016476534,
0.011002116,
-0.012094336,
-0.02257698,
-0.0034265064,
0.007598919,
0.025573926,
0.017515475,
-0.011694743,
0.011961138,
0.0047984407,
0.013606127,
0.0098299775,
-0.0023259618,
-0.025547286,
-0.0161835,
-0.008744418,
0.016636372,
0.0041724127,
-0.015557471,
-0.02964977,
0.005487738,
-0.002312642,
-0.021791115,
0.011148633,
-0.00913069,
0.019433519,
0.0026156665,
0.021458121,
0.025161013,
-0.027252214,
-0.016423255,
-0.03777482,
-0.0020662267,
-0.022270627,
0.014798245,
0.01290018,
-0.01617018,
-0.00021124295,
-0.028371073,
-0.027678447,
0.0058074123,
0.0013910817,
-0.01293348,
-0.025667163,
-0.010362768,
-0.03785474,
-0.029223537,
0.025986837,
-0.0066965055,
0.0172624,
0.00032924765,
-0.0066665364,
-0.0054078195,
-0.011095354,
-0.012493928,
-0.010402727,
-0.014585129,
-0.007705477,
0.032739952,
-0.0039126775,
0.00969678,
0.020206064,
0.012061036,
0.041184675,
0.014238816,
0.007379143,
-0.009243908,
0.0182747,
-0.009803338,
-0.024974536,
0.025533967,
0.025973517,
-0.007905274,
0.012547207,
0.03015592,
-0.011568205,
0.053145815,
-0.013499569,
0.0018064915,
-0.012114315,
0.00862454,
-0.004219032,
0.018740892,
0.017129201,
-0.01129515,
0.0026273213,
-0.019500118,
-0.014878164,
-0.01993967,
0.026706105,
0.0152111575,
-0.011161953,
-0.009350467,
-0.019673275,
0.005824062,
0.013825904,
-0.00862454,
0.0064001414,
-0.0130000785,
0.0038161092,
0.029330095,
0.005121445,
0.01505132,
-0.021404842,
-0.011055395,
-0.009084071,
0.0046619135,
0.0345248,
0.017608713,
0.00080501253,
0.0066931755,
-0.014265455,
0.030901827,
0.017901748,
0.013306433,
0.017701952,
0.00018845369,
-0.0152111575,
-0.005764123,
0.023336207,
0.027385412,
0.036229726,
0.00700619,
0.010695761,
-0.022736818,
0.03279323,
0.003293309,
-0.012120975,
-0.011255191,
-0.0086378595,
0.0014485231,
0.0125205675,
0.03436496,
0.025001176,
0.0365494,
0.021644598,
-0.015024681,
0.008984174,
0.008291546,
-0.00080168265,
0.005058176,
-0.020086188,
0.005717504,
-0.020285983,
-0.020112827,
-0.006236974,
-0.007878634,
-0.023562642,
0.008384785,
-0.0045586852,
-0.0019679936,
0.019633316,
0.015264437,
-0.0035197446,
-0.017555434,
-0.06761107,
0.024162032,
0.014332054,
-0.0024391797,
-0.004628614,
-0.011255191,
0.013319753,
-0.014718327,
0.025454048,
-0.015104599,
0.0022493734,
0.012107655,
0.01883413,
-0.003389877,
-0.019540077,
0.039506387,
-0.01130181,
0.023296248,
-0.019886391,
-0.007099428,
0.008138369,
-0.01238071,
-0.014212176,
0.009210609,
0.01074904,
-0.034871113,
0.0143720135,
-0.009803338,
-0.0071260678,
0.014771606,
-0.022217348,
-0.0020862063,
-0.020765495,
-0.00036171454,
0.0124606285,
-0.02426859,
0.00029553202,
0.01678289,
-0.01992635,
0.00965682,
-0.03289979,
-0.019087207,
0.020232704,
0.02216407,
0.015757268,
-0.0008420581,
-0.0050914753,
0.018940689,
0.026279872,
0.01563739,
-0.03508423,
0.019300321,
-0.001293681,
-0.019060567,
-0.03015592,
0.01453185,
-0.0031484566,
0.004408838,
0.020112827,
-0.0015001372,
-0.016876128,
0.00020406277,
-0.0017881768,
0.016063621,
-0.010083053,
0.02794484,
0.01615686,
0.022883335,
-0.01932696,
0.0053145816,
0.036895715,
0.01780851,
-0.018194782,
-0.0002982376,
-0.017608713,
-0.014904804,
0.03012928,
0.013226515,
-0.03279323,
-0.005494398,
-0.0012337421,
0.0039892658,
0.009403746,
0.014145577,
0.017994987,
0.01342631,
0.018647654,
0.0008832661,
-0.0044388077,
0.0076122386,
-0.0108489385,
0.013093317,
-0.018700933,
0.015957063,
0.004908329,
-0.020805454,
-0.0148515245,
0.0058773407,
-0.0004853385,
0.00091323553,
-0.008424744,
0.0049815876,
-0.008844316,
-0.0037927995,
-0.033992007,
-0.015504193,
-0.0027055747,
0.027172295,
-0.028637469,
-0.00062561216,
-0.0020961962,
0.030528873,
-0.0010955497,
0.009849957,
-0.014438612,
-0.0069662305,
0.0040658545,
0.007099428,
0.000103019964,
-0.013706026,
-0.013406331,
0.0036462822,
0.035244066,
0.002204419,
0.009750059,
-0.005294602,
-0.005497728,
-0.002907036,
-0.008384785,
0.01723576,
-0.019233722,
-0.009630181,
0.04310272,
0.009070751,
-0.004152433,
0.023096452,
-0.018154822,
-0.0215114,
0.0012961784,
0.021844395,
0.017355638,
-0.015903784,
0.0049316385,
0.013319753,
0.00017492581,
-0.002910366,
-0.036442842,
-0.009437045,
-0.0038693883,
0.0002303901,
-0.000888261,
0.018487817,
-0.030555513,
-0.016503174,
0.0150912795,
-0.0006976221,
0.0023376166,
0.006623247,
0.002910366,
-0.0194202,
0.0043455693,
-0.00538451,
0.006729805,
-0.015544152,
0.003726201,
0.041610908,
-0.029729689,
-0.0058407118,
0.019553397,
0.027358772,
-0.013945781,
-0.011375069,
0.004961608,
0.009044112,
0.049363002,
-0.00031030862,
-0.025134373,
-0.023123091,
-0.007805375,
-0.016290057,
-0.010322808,
-0.01180796,
0.002374246,
0.002146145,
0.00537452,
-0.02754525,
-0.000042014453,
-0.0040492048,
-0.024841338,
-0.011694743,
0.0020778815,
0.0019729885,
0.035776857,
-0.010662462,
-0.00020499932,
-0.0443015,
-0.00969012,
-0.006506699,
-0.019087207,
0.020152787,
-0.01566403,
0.01995299,
0.025147693,
0.012806943,
-0.010442686,
-0.0052679623,
0.006023858,
0.022497062,
0.014478571,
-0.005570987,
-0.0027888233,
-0.0150912795,
0.01290684,
0.002860417,
0.0039060174,
0.02147144,
-0.0335125,
0.022763457,
0.026546268,
-0.02208415,
-0.01824806,
-0.0009998139,
-0.031487897,
-0.0117480215,
-0.0010539255,
0.008251587,
0.008424744,
-0.017062603,
0.0001797126,
0.010882238,
0.022470422,
0.022363866,
0.03138134,
0.03287315,
-0.016423255,
0.0017548774,
0.020312622,
0.021351563,
-0.0012012752,
-0.03076863,
-0.012773643,
-0.02959649,
0.03385881,
-0.016529813,
-0.010802319,
0.013219855,
-0.012966779,
-0.014878164,
0.0016807863,
-0.025174333,
0.012687065,
-0.019753193,
0.0074124425,
-0.011361749,
-0.02685262,
-0.012314111,
-0.04803103,
0.011994437,
0.024921257,
-0.010449346,
0.008478022,
-0.0071460474,
-0.0044554574,
0.008671159,
-0.00019542575,
0.03990598,
-0.0006830536,
-0.0023659212,
0.01786179,
-0.0062636137,
-0.017622033,
-0.013852543,
0.008351485,
0.006853013,
0.03228708,
0.0322338,
-0.0053145816,
0.0068796524,
0.027238894,
0.009650161,
-0.046992086,
-0.037028912,
0.013093317,
0.0006331045,
0.020658936,
0.0049749278,
0.006846353,
-0.014345374,
0.02480138,
-0.0172624,
0.006579958,
-0.0013819244,
-0.012780303,
-0.022870015,
0.016063621,
-0.0046086344,
0.024867978,
0.00092405785,
-0.03116822,
-0.004888349,
-0.025893599,
-0.0030302438,
-0.00083331706,
0.008791037,
0.01826138,
0.001723243,
-0.0121609345,
0.0073525035,
-0.0015967054,
0.0062902533,
-0.0225903,
-0.031088304,
0.035457183,
-0.006716485,
-0.0004066687,
0.027358772,
0.0048084306,
-0.024468387,
-0.016036982,
-0.0015667359,
-0.015410954,
-0.027332133,
-0.014065659,
0.017715272,
-0.0058606914,
-0.0128802005,
0.0029386703,
-0.008344825,
-0.007492361,
0.0061437357,
-0.024481706,
0.026506308,
-0.036203086,
-0.0008233272,
-0.014651728,
0.019526757,
0.011768001,
-0.008404764,
0.008877615,
0.0011097019,
0.03170101,
-0.019020608,
-0.00016618473,
0.012653765,
0.02156468,
0.0026622855,
-0.004751822,
-0.02421531,
-0.017475516,
0.004701873,
0.006899632,
-0.019007288,
-0.029756328,
0.0014626754,
0.020872053,
0.011668104,
-0.038067855,
0.02152472,
0.00030177564,
0.01451853,
0.005754133,
-0.028291155,
0.003882708,
-0.012513908,
-0.0033432578,
-0.004022565,
0.0027188945,
-0.0048051006,
0.012973439,
-0.031914126,
0.005644245,
-0.033112906,
0.009650161,
0.0014868174,
0.0070195096,
-0.04094492,
-0.00376949,
0.011068715,
0.0016300047,
-0.015730629,
0.0043222597,
-0.0011405038,
-0.01617018,
-0.02794484,
0.002747199,
0.0005215516,
0.010469326,
-0.005814072,
0.010542585,
0.017675312,
-0.0073058843,
-0.029356735,
-0.024348509,
-0.016902767,
0.031461257,
0.0025923569,
-0.013692706,
-0.011568205,
0.005980569,
-0.06409465,
0.0009090731,
-0.017648673,
0.008784377,
-0.00968346,
0.00051738915,
0.0013236505,
0.041211314,
0.0112085715,
-0.00011353008,
0.0048117605,
-0.0129135,
0.009723419,
-0.012493928,
0.02000627,
-0.021404842,
-0.053572044,
-0.002377576,
0.041211314,
-0.013852543,
-0.020232704,
0.0039925957,
-0.01401238,
-0.0030435636,
-0.028770667,
0.029942805,
-0.013512889,
-0.022790097,
0.01569067,
-0.009929876,
-0.0008125049,
-0.00646674,
-0.00028908026,
-0.009636841,
-0.009909896,
0.0012478944,
0.01782183,
0.00090740813,
-0.017688632,
-0.015797228,
-0.017622033,
-0.041184675,
0.011534906,
0.02209747,
-0.00913069,
-0.017981667,
0.020618977,
-0.01724908,
-0.033619057,
0.009190629,
0.023322888,
-0.001295346,
0.0058606914,
-0.0009856618,
-0.0007313377,
0.021458121,
-0.011594845,
0.019287001,
-0.017049283,
0.011728043,
-0.04853718,
-0.030662071,
-0.01127517,
-0.0050748256,
-0.015410954,
-0.00029698887,
0.0023859008,
-0.0015459238,
-0.00376283,
-0.018674294,
0.017302359,
-0.007758756,
-0.02369584,
0.008904255,
-0.02099193,
0.019806473,
0.003939317,
-0.012826922,
-0.008498002,
0.011887879,
0.17901748,
-0.01786179,
-0.0035097548,
0.0018730903,
-0.015930424,
-0.00032945577,
0.02478806,
0.0055310274,
-0.025720442,
0.012587166,
0.02754525,
-0.015144559,
-0.008464702,
0.0027039098,
-0.01671629,
-0.016569773,
-0.03281987,
0.00092405785,
-0.02364256,
-0.012547207,
0.011901199,
-0.012653765,
0.0024325198,
-0.010822299,
0.019726554,
0.00966348,
0.005174724,
-0.027332133,
0.008471362,
0.009969835,
-0.030182559,
-0.02148476,
-0.004435478,
-0.0022310587,
-0.02105853,
-0.0053978297,
-0.0269059,
-0.00061978475,
0.0028770666,
0.0033565776,
-0.021857714,
0.011721383,
-0.040412128,
-0.013932461,
-0.011561546,
0.00969012,
-0.0056342552,
-0.024042154,
-0.0030102641,
-0.014598449,
-0.033992007,
-0.0128802005,
0.016330017,
-0.012480608,
-0.010402727,
-0.01024289,
0.012513908,
0.020179426,
-0.012207554,
0.024921257,
-0.006370172,
-0.0075123403,
-0.0070794486,
0.033352662,
-0.04158427,
0.04083836,
0.0019080546,
-0.00022497895,
0.01778187,
0.0033582426,
-0.0021411502,
0.0006468405,
-0.01561075,
-0.0017115882,
0.008198308,
-0.022004232,
0.029489933,
0.018354619,
0.009237248,
0.026746063,
-0.0038893677,
-0.016849488,
-0.025187653,
0.007965212,
-0.010322808,
-0.029250177,
0.009077411,
-0.008764397,
-0.014172217,
0.0033216134,
0.003826099,
0.008344825,
-0.012480608,
-0.00032321212,
0.024468387,
0.004155763,
0.006190355,
-0.015224477,
0.014305415,
-0.01130847,
-0.01559743,
0.05919298,
-0.016423255,
0.0112085715,
-0.011534906,
0.001881415,
-0.008231607,
-0.0038660583,
-0.010316148,
-0.008384785,
-0.003722871,
-0.057434775,
0.0063435324,
-0.019300321,
0.0043921885,
0.026679466,
0.002146145,
-0.015890464,
0.024881298,
-0.0152111575,
0.023829037,
-0.015544152,
0.009536943,
-0.008837656,
-0.011408368,
0.00700619,
-0.011055395,
-0.011887879,
-0.00059605896,
-0.01996631,
-0.004362219,
0.005121445,
-0.0019513437,
-0.003975946,
-0.026040116,
-0.02255034,
0.0148515245,
-0.0049749278,
-0.022417143,
0.029250177,
0.0033032987,
-0.009010812,
0.008571261,
0.0002982376,
-0.011395048,
-0.021910993,
0.023882316,
-0.001987973,
-0.013706026,
-0.011987777,
-0.0077454364,
-0.011062055,
0.0000654541,
-0.007652198,
-0.0010431032,
0.024361828,
-0.004895009,
-0.027079057,
-0.003612983,
0.009723419,
-0.03015592,
-0.0018614355,
0.026492989,
-0.012274153,
-0.005051516,
0.01932696,
-0.16825512,
0.019833112,
0.0015659034,
-0.016942725,
0.036416203,
-0.02101857,
0.026026797,
0.004778461,
-0.008784377,
-0.022044191,
0.034764554,
-0.011774661,
-0.026080076,
-0.010416047,
-0.016383296,
-0.0018581055,
-0.029410014,
0.007598919,
-0.0020146125,
0.0070261694,
0.0070195096,
-0.04209042,
0.019473478,
-0.013506229,
0.010162971,
0.01671629,
0.004025895,
-0.0035164147,
0.012553867,
0.029303456,
0.0030968424,
-0.01129515,
0.059086423,
-0.00008236394,
0.0055210376,
-0.0010339458,
0.002156135,
-0.010109692,
0.009796678,
0.016929405,
0.014198856,
0.034604717,
0.008870956,
-0.004641934,
-0.038094494,
0.0152111575,
0.0204325,
-0.013033378,
0.0058873305,
-0.01237405,
0.006853013,
-0.012274153,
0.008571261,
0.016236778,
0.008444724,
-0.011035415,
0.0063468623,
0.0017632023,
0.0172624,
-0.02212411,
-0.019526757,
0.020059548,
0.022417143,
0.00040354687,
0.020219384,
-0.04158427,
0.0019013947,
-0.046006426,
-0.008651179,
0.024321869,
-0.01786179,
-0.0019063896,
0.00031467917,
-0.021764476,
0.0007700482,
0.026146675,
-0.028770667,
0.013799264,
-0.0023276268,
-0.0064800596,
-0.015424274,
0.016836168,
-0.032073963,
-0.0032766592,
0.0043255896,
-0.0073658233,
-0.000632272,
0.0027721736,
-0.019633316,
0.002642306,
0.01344629,
-0.0247481,
0.016036982,
-0.01020959,
0.0247481,
0.018168142,
-0.008964194,
0.024881298,
0.018008307,
-0.018967329,
0.020832093,
-0.021844395,
-0.01614354,
0.010862258,
0.03340594,
0.0048783594,
-0.00084538804,
0.0029819596,
0.016862808,
-0.012054376,
-0.00040000884,
0.015144559,
0.005174724,
-0.0029253508,
-0.0031118272,
0.013692706,
0.0067431247,
-0.018434538,
0.0063335425,
-0.001726573,
0.067930736,
0.0062169945,
0.005294602,
0.009383766,
-0.009297187,
-0.02694586,
-0.118812196,
-0.024641542,
0.012294131,
0.014438612,
-0.0028620819,
0.0024691492,
0.004422158,
0.014451932,
-0.0059572593,
0.010802319,
-0.029196898,
-0.027198935,
-0.00064059685,
-0.0074790413,
0.005660895,
0.015464233,
0.016583093,
-0.010336128,
-0.039186712,
0.041131396,
-0.014345374,
0.0058440417,
0.017049283,
-0.008165008,
-0.010888898,
-0.021657918,
-0.019500118,
0.015197838,
0.007439082,
0.03564366,
0.010629163,
-0.013666066,
0.02751861,
0.0061170966,
-0.014039019,
-0.0019047246,
-0.004898339,
-0.010056414,
0.029889526,
0.0065000392,
-0.015837185,
-0.006256954,
-0.017875109,
-0.00075381476,
0.028744027,
-0.011015436,
-0.022936614,
-0.003656272,
0.012081016,
-0.001669964,
0.0046719033,
-0.034871113,
-0.0071327277,
-0.024082113,
0.036309645,
-0.0023609262,
0.0040025855,
0.020499099,
-0.011661444,
-0.007931912,
-0.0077520963,
-0.0014726651,
0.010396067,
0.008284886,
0.03068871,
0.0048117605,
0.012294131,
-0.03657604,
0.018527776,
0.0045919847,
0.00753898,
0.0017915068,
-0.014265455,
-0.008344825,
-0.023402806,
0.009303847,
-0.034897752,
-0.022750137,
0.011248531,
-0.030635431,
-0.016290057,
-0.016916087,
0.0023559313,
-0.0075056804,
0.01558411,
0.026293192,
0.0061304164,
-0.01181462,
0.026959179,
-0.029276816,
-0.0016866137,
0.019779833,
-0.0010830624,
0.0025657173,
-0.016836168,
0.01507796,
-0.002044582,
-0.029143618,
0.020845413,
0.016676331,
-0.020299302,
-0.024867978,
-0.055356894,
0.012866881,
0.012327431,
0.0027804985,
0.0033732273,
-0.009457025,
0.022417143,
0.0026206614,
0.013706026,
-0.030289117,
-0.026719425,
0.017155841,
0.009976495,
0.007392463,
-0.025161013,
0.020206064,
0.03297971,
0.019433519,
0.046139624,
0.03982606,
-0.0036895715,
0.0062236544,
-0.020032909,
0.035137508,
-0.002645636,
-0.0030785277,
-0.008011831,
0.0070328293,
-0.01397242,
-0.004948288,
0.016876128,
-0.00590398,
-0.013532869,
0.012094336,
0.008804357,
-0.005504388,
0.0029852896,
0.011135314,
0.0152111575,
0.021205047,
-0.020912012,
-0.03276659,
0.04574003,
-0.023109771,
0.0036196427,
0.002257698,
-0.019659955,
-0.0142521355,
0.02425527,
-0.0077321166,
-0.015171198,
0.017648673,
0.0121009955,
-0.017382277,
-0.030448955,
0.032473557,
0.015850505,
-0.016916087,
-0.011435008,
-0.02901042,
0.0082182875,
-0.0024558294,
-0.02362924,
0.008384785,
-0.00003218073,
-0.000045344394,
-0.009004153,
0.0051980335,
0.033139545,
-0.027705086,
-0.008291546,
0.0022310587,
0.01347293,
-0.008857636,
0.011201912,
0.008165008,
-0.040145736,
0.0012470619,
0.007845335,
0.005427799,
-0.0033432578,
-0.02537413,
-0.0451806,
0.02643971,
-0.004738502,
-0.011741362,
-0.007705477,
0.0064767296,
-0.012607146,
0.0050381967,
-0.009323827,
0.034151845,
-0.022310587,
0.009969835,
-0.004212372,
0.027918201,
0.02686594,
-0.014571809,
0.026000157,
0.024042154,
0.009183969,
-0.007865314,
-0.004631944,
0.0075656194,
-0.015823867,
-0.0025757072,
-0.02743869,
-0.024042154,
-0.007312544,
0.026173314,
0.016822848,
0.0057241637,
-0.004239011,
0.0022343886,
0.0053378907,
0.002532418,
0.022883335,
0.003879378,
-0.017515475,
0.016330017,
0.017009323,
-0.005014887,
0.019526757,
0.013932461,
0.0011738032,
0.0127603235,
0.025587246,
-0.023469405,
0.006200345,
0.004239011,
0.023402806,
-0.0027888233,
-0.024921257,
-0.0058906605,
-0.012587166,
-0.016902767,
-0.002907036,
0.014172217,
-0.008145029,
0.08423412,
0.011761341,
0.0047052028,
0.008857636,
0.015490873,
0.012587166,
-0.0033182835,
0.030502234,
-0.043422394,
-0.001613355,
-0.0008824336,
-0.025693802,
0.00035692775,
-0.025227612,
-0.047711354,
0.018367939,
0.0028987112,
0.02318969,
-0.017608713,
-0.027838282,
0.029809607,
-0.0060038785,
0.0032450247,
-0.0040092454,
-0.0037994594,
-0.0053944997,
0.035403904,
0.015131239,
-0.019087207,
-0.01932696,
-0.0215114,
0.00067889114,
-0.007838675,
-0.002848762,
-0.00013205287,
-0.042196978,
-0.0072059864,
-0.008491342,
0.016796209,
0.009869937,
0.013359712,
0.03876048,
-0.009203949,
-0.022470422,
0.0004224859,
-0.014025699,
0.013566168,
-0.009250568,
-0.026186634
] |
Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its regulation. Whereas most RNP enzymes are stable in composition and harbor preformed active sites, the spliceosome, which removes noncoding introns from precursor messenger RNAs (pre-mRNAs), follows fundamentally different strategies. In order to provide both accuracy to the recognition of reactive splice sites in the pre-mRNA and flexibility to the choice of splice sites during alternative splicing, the spliceosome exhibits exceptional compositional and structural dynamics that are exploited during substrate-dependent complex assembly, catalytic activation, and active site remodeling. | [
-0.031338714,
-0.00069274165,
-0.0006210933,
-0.014868932,
-0.016252719,
0.00661369,
0.008424823,
0.0031423506,
-0.017405875,
-0.012786468,
0.016334118,
-0.008506223,
-0.010771835,
-0.0028930653,
0.010425889,
0.010181691,
0.025912099,
0.0054910583,
0.012135273,
-0.002021415,
-0.025640767,
0.0007817721,
-0.022506896,
-0.040726762,
0.020458348,
0.019983519,
0.00841804,
-0.030334791,
-0.0066102985,
-0.035815675,
-0.0066916975,
-0.012684719,
-0.028245544,
-0.0096051125,
0.00019788076,
0.007821112,
0.013491928,
-0.03139298,
-0.021421572,
-0.0076515307,
0.036792465,
0.01598139,
-0.020078484,
0.0043243356,
0.015832156,
-0.0012803426,
-0.02280536,
0.004554967,
-0.021367306,
0.01903386,
0.010670086,
-0.008648671,
-0.032749638,
-0.008153493,
-0.007997477,
0.0002588242,
-0.0257086,
0.007312367,
0.0021299473,
-0.017012445,
-0.0023114,
-0.0059658876,
-0.028245544,
0.013376612,
-0.008390907,
0.014217738,
0.020187017,
0.0029235901,
0.0025182897,
0.00034043545,
0.030253392,
-0.0049483967,
-0.018938895,
0.015085996,
0.02100101,
-0.046207648,
-0.0075769145,
0.0031881377,
-0.015886422,
0.008675804,
0.017812872,
-0.008696155,
0.010269874,
0.014665433,
0.01432627,
-0.009998542,
0.018586164,
0.009801827,
0.01507243,
-0.011443379,
0.028625406,
0.05087454,
0.020024218,
0.02245263,
-0.028733939,
-0.012413387,
0.0041242293,
0.01762294,
-0.010480155,
-0.009686512,
-0.024392646,
0.028761072,
-0.015669357,
-0.0071156523,
-0.02707882,
0.010276657,
-0.018070636,
-0.025613634,
0.027567217,
0.017243076,
0.00841804,
0.023700751,
-0.019088127,
-0.027770715,
0.024189148,
-0.006678131,
0.031935643,
-0.023144523,
0.0027421375,
-0.01507243,
0.01950869,
0.014991031,
0.019183092,
-0.036358338,
0.051797062,
0.00012930612,
0.0076990137,
0.0027421375,
0.00055580435,
-0.007346283,
0.0061049447,
0.018070636,
-0.0012837342,
0.029846396,
-0.008920003,
-0.0076447474,
0.0006855344,
-0.0097000785,
-0.009733995,
-0.0401027,
0.0220592,
0.033780694,
-0.03744366,
-0.008858953,
0.005158678,
-0.00037583566,
0.033590764,
0.0051281536,
0.013105281,
-0.00037202006,
0.012664368,
-0.0024453695,
0.011043167,
-0.019942818,
0.0059930207,
0.025817132,
-0.003298366,
0.020200584,
0.012101357,
0.00841804,
0.010466589,
-0.002375841,
0.013573327,
0.01393284,
0.0064135836,
0.02174717,
-0.00588788,
0.0007622702,
0.011640094,
-0.0033695903,
0.0007508234,
-0.00341029,
-0.03481175,
0.030524723,
-0.0031033468,
-0.00010757845,
0.01181646,
0.013057798,
-0.029547932,
-0.011999608,
0.022439063,
-0.009449097,
0.023958515,
0.0023351414,
-0.0077193636,
-0.007970344,
0.02610203,
0.011226315,
0.015913555,
-0.007434466,
-0.021950668,
0.0010471676,
0.01244052,
-0.01212849,
-0.6346972,
-0.030877454,
0.027689315,
-0.037199464,
0.01872183,
0.015411594,
0.0067595304,
-0.0083162915,
-0.0008920003,
0.02755365,
-0.016144186,
0.012067441,
0.029737864,
-0.022832492,
-0.037470795,
-0.03348223,
0.006020154,
-0.010025675,
0.03820339,
-0.018898195,
-0.022547595,
-0.0025471186,
-0.007963561,
0.017989237,
0.021909967,
-0.011280581,
0.03524588,
0.00072538614,
-0.010317356,
0.012732201,
-0.0076718805,
0.016496917,
-0.035110217,
0.023266623,
0.04965355,
0.022628995,
-0.015479426,
0.021014577,
0.025165938,
0.041974887,
-0.019183092,
0.00106243,
0.023280188,
0.0033305865,
-0.003727408,
-0.0068307547,
0.0051756366,
0.008736854,
-0.0019027077,
-0.033319432,
-0.0021519929,
0.0016381601,
-0.010317356,
0.023768585,
-0.018029936,
0.009455881,
0.025518669,
-0.018681131,
0.029575065,
-0.0069392873,
-0.0065255077,
0.009679729,
-0.008492656,
-0.025206639,
-0.02182857,
-0.0071020857,
-0.010873585,
-0.00045702295,
-0.0017840005,
0.010507288,
0.002896457,
0.023578653,
0.0013363046,
-0.012515136,
-0.018871062,
0.020824645,
-0.013532627,
0.014584035,
-0.000838158,
0.032044176,
-0.005450359,
-0.0044294763,
-0.030280525,
-0.007760063,
0.02794708,
-0.0017382134,
-0.019128827,
0.017053146,
0.028679673,
-0.0103444895,
0.0046804575,
-0.003652792,
-0.0061219027,
-0.040292636,
-0.049409352,
0.0016322248,
0.0028201453,
0.00266413,
0.013668293,
-0.017690772,
-0.020824645,
0.0018569207,
0.010249523,
-0.0109549835,
0.02123164,
-0.0046567162,
-0.02610203,
0.00043624916,
0.02610203,
-0.027105954,
-0.000003481064,
-0.01864043,
-0.010134208,
-0.01140268,
-0.019006727,
-0.026386928,
0.024691109,
0.0041513625,
-0.0013591981,
-0.03882745,
-0.00341029,
-0.0035103431,
-0.008899652,
-0.02280536,
-0.002112989,
0.016334118,
0.008716504,
-0.018165601,
-0.002542031,
-0.0021265557,
0.0072038346,
-0.008451956,
0.017840005,
-0.02170647,
0.014597601,
0.033265166,
0.0072920173,
0.0028150578,
0.002021415,
-0.03700953,
-0.0055826325,
-0.0059217964,
-0.026916023,
-0.031013118,
-0.016496917,
-0.018979594,
-0.043033075,
0.019440858,
0.015058863,
0.009815394,
0.009014968,
0.012671152,
-0.01613062,
0.015153829,
0.0041513625,
-0.012610102,
-0.020729678,
-0.021909967,
-0.015533692,
-0.00068341463,
0.0063016596,
0.011178832,
-0.006684914,
0.0137225585,
-0.018057069,
-0.028598273,
0.008987836,
-0.0038155904,
0.010046026,
-0.03603274,
0.010663304,
0.013905707,
-0.016754681,
-0.0002560685,
0.010079942,
0.017555108,
-0.009639029,
0.013803958,
0.026522594,
-0.0070274696,
-0.015642224,
-0.004449826,
-0.019101694,
-0.014054939,
0.007922862,
0.027689315,
0.038149122,
-0.008207759,
0.022737527,
0.012989965,
-0.0018331792,
0.024826774,
-0.008797904,
0.033916358,
-0.004677066,
-0.022818927,
0.021557238,
0.014000673,
-0.020309117,
0.0054130508,
0.022235565,
0.0015075821,
-0.007902511,
-0.03557148,
0.00069825305,
-0.02241193,
0.010812535,
-0.0044769594,
-0.0019874987,
0.0046228,
-0.021136675,
-0.0145569015,
-0.013254513,
-0.023619352,
-0.0055487165,
0.025369437,
-0.014475502,
0.011524779,
-0.0043921685,
-0.012393038,
0.009489797,
-0.024107749,
0.032125574,
-0.008221325,
-0.010256307,
0.02597993,
-0.012006391,
0.010032459,
-0.006885021,
-0.021516537,
0.013037449,
0.022466196,
-0.0037952405,
0.0014745137,
0.015438727,
0.017975671,
0.006352534,
-0.016225586,
0.03901738,
0.0005596199,
-0.023972083,
-0.003166092,
0.0067018727,
-0.010724353,
0.014760399,
-0.011504429,
0.030958852,
0.0128543,
-0.009639029,
0.02865254,
-0.014936765,
0.007882162,
-0.015289495,
0.002375841,
0.013959973,
-0.0073530665,
0.014977464,
0.010059592,
0.058933064,
0.015235228,
0.004799165,
-0.0120810075,
0.007305584,
-0.010079942,
-0.015153829,
-0.02154367,
0.013552977,
-0.015832156,
-0.008282375,
-0.008431607,
-0.030877454,
-0.016361251,
0.0009920535,
-0.010737919,
0.009706862,
0.02029555,
0.0051078037,
0.03340083,
0.013308779,
-0.006501766,
-0.01727021,
-0.020512614,
0.037307996,
0.016510483,
-0.027702883,
-0.023497254,
-0.053018052,
0.022601862,
-0.0046567162,
0.016225586,
-0.0004349773,
0.017582241,
-0.019101694,
0.02775715,
0.0023351414,
-0.0072988006,
0.037335128,
-0.023741452,
0.024840342,
-0.022032067,
0.0075497814,
-0.0049483967,
-0.009109934,
-0.021448705,
0.05790201,
-0.0047211573,
-0.01208779,
0.00009761552,
0.0058539636,
-0.011572261,
-0.0074005495,
-0.010127425,
0.01950869,
-0.026671825,
-0.014801099,
-0.019603655,
-0.018355533,
0.007142785,
0.021679336,
0.0050738873,
-0.009971409,
-0.016252719,
0.025966365,
0.015560825,
0.011612961,
0.032288373,
0.0024148447,
0.00959833,
-0.024555445,
-0.012067441,
-0.011511212,
-0.0021163807,
0.0061219027,
-0.023822851,
-0.0026183429,
0.009469448,
0.0012532094,
0.008234892,
-0.0039749974,
0.014692566,
0.014407669,
-0.029059537,
-0.007488732,
-0.018708264,
0.01778574,
0.0059862374,
0.016062787,
0.023063125,
0.012250589,
0.011002467,
0.0009462664,
0.019983519,
0.010453022,
-0.033699293,
0.009544063,
0.004256503,
-0.014950331,
-0.006091378,
-0.008858953,
-0.023307322,
0.03709093,
0.010364839,
0.010486938,
0.0084790895,
0.024067048,
0.011938558,
0.019440858,
0.0050908453,
-0.00013110792,
0.00081568846,
-0.0042429366,
0.008295941,
-0.012644019,
-0.011504429,
0.014272004,
0.002981248,
-0.0069155456,
-0.010520855,
0.002813362,
-0.011782543,
-0.005599591,
-0.011707927,
0.015262362,
-0.021448705,
0.0043718186,
-0.011165265,
0.00528756,
-0.003010077,
0.012426954,
-0.017120978,
-0.00095728924,
0.006325401,
-0.0067866636,
-0.0027031337,
0.017338043,
-0.039153043,
-0.028191278,
-0.014109205,
0.0219371,
0.026074897,
0.012752551,
-0.022642562,
0.011389113,
0.018748963,
-0.012365905,
-0.014679,
0.018192735,
-0.038610384,
-0.0021435139,
-0.013824308,
-0.008139926,
-0.011796109,
-0.014489069,
-0.031610046,
0.015167396,
-0.0056606405,
0.011667227,
0.006305051,
-0.0019705405,
0.039831374,
0.017297342,
0.056382556,
0.0102156075,
-0.0073530665,
-0.008709721,
-0.01507243,
-0.018545466,
-0.048025563,
0.0029778564,
0.0031491339,
0.0068477127,
0.011185615,
0.0022520463,
-0.018694697,
0.021218074,
-0.002981248,
-0.00033979953,
0.032234106,
0.0032949743,
0.029737864,
-0.014638301,
0.035028815,
0.012705068,
0.0031779627,
-0.023972083,
-0.0059387544,
0.022791794,
-0.0036222672,
-0.030524723,
0.012630452,
-0.019060994,
-0.028761072,
-0.008750421,
0.0070071197,
-0.007827896,
0.0551887,
0.010737919,
-0.04148649,
0.012956049,
-0.01950869,
-0.0018399624,
0.00311013,
-0.006725614,
0.009537281,
-0.0122098895,
0.012406604,
-0.027811414,
0.005195986,
0.0019366241,
-0.030470457,
0.0074683824,
0.007868595,
0.0008996314,
0.009279516,
-0.004843256,
-0.005999804,
-0.04007557,
-0.011891075,
-0.002190997,
-0.029140936,
-0.0073395,
-0.018735398,
0.048758157,
0.021909967,
0.018735398,
0.0011565478,
0.0008313747,
0.005664032,
0.02083821,
-0.019305192,
0.019440858,
-0.0047482904,
-0.014489069,
0.019793587,
0.032234106,
0.009883227,
0.0038698565,
-0.0135597605,
-0.0013108673,
0.0077532795,
-0.0059760623,
-0.02684819,
0.013376612,
-0.031175917,
-0.029330866,
0.0076515307,
-0.006729006,
-0.012603319,
-0.036494,
-0.0024080614,
-0.0054367925,
-0.0042598946,
0.019562956,
-0.0057793474,
0.033102367,
0.008818253,
0.017555108,
-0.014733266,
0.005419834,
-0.014394103,
-0.0035035599,
-0.014231305,
0.0035510429,
-0.0010480155,
-0.012671152,
0.026129164,
0.01104995,
-0.015031731,
0.015018164,
-0.0037138413,
-0.034594685,
-0.0026217345,
0.021408007,
-0.0036934915,
-0.012779684,
-0.01585929,
0.010554771,
-0.03179998,
-0.00067111995,
0.013064582,
-0.00024440975,
-0.00348321,
-0.02473181,
-0.020661846,
0.035001684,
-0.009279516,
0.021638637,
-0.0057623894,
0.014733266,
0.024908174,
-0.017338043,
-0.009109934,
-0.023361588,
-0.011490863,
-0.0070681693,
0.034676086,
0.017772172,
-0.0019111868,
-0.015533692,
-0.011368764,
-0.018450499,
-0.011287364,
-0.036955263,
0.010887152,
-0.035381544,
0.0000624273,
-0.010758269,
0.030850321,
-0.0010420801,
0.020892477,
-0.02500314,
0.0054062675,
0.0018128294,
-0.0019976737,
-0.015669357,
0.0076922304,
0.003176267,
0.007977128,
-0.015140262,
-0.029113803,
0.0023995824,
-0.018450499,
0.019874986,
0.013057798,
0.003930906,
0.03909878,
0.00020869159,
0.0030168602,
0.009191333,
0.0063389675,
0.00014753616,
-0.0115993945,
-0.0010319052,
0.040482566,
-0.0046228,
-0.0017127761,
0.02829981,
0.017677207,
-0.00014912599,
0.0035510429,
0.010710786,
-0.005311302,
-0.022235565,
-0.0020977268,
0.013647943,
0.012142057,
-0.029059537,
-0.015791457,
0.0050603207,
0.0042225868,
-0.018369101,
-0.017107412,
0.014244871,
-0.03508308,
-0.022357663,
0.005955713,
0.032532573,
0.029737864,
0.008214542,
0.0040292633,
-0.014448369,
0.021787869,
-0.015208095,
0.018301267,
-0.0026030806,
-0.013763258,
-0.0153301945,
0.005131545,
-0.021408007,
-0.026522594,
0.017120978,
-0.02684819,
-0.024474045,
0.02351082,
-0.0018670956,
0.016035654,
0.022886759,
-0.021597937,
0.020946743,
-0.010622604,
0.0014779053,
0.001713624,
-0.01397354,
0.0010938026,
-0.025559368,
-0.003839332,
0.00079364283,
0.011945342,
-0.023022424,
0.0014575556,
-0.027716449,
0.0039173393,
0.00013937504,
-0.01683608,
-0.02280536,
-0.004514267,
-0.01731091,
-0.015085996,
0.017514408,
-0.013125631,
-0.016537616,
0.009523714,
0.02971073,
-0.008356991,
-0.005511408,
-0.007658314,
0.019617222,
0.013586894,
-0.02908667,
-0.0028727157,
0.009564414,
-0.02488104,
-0.02013275,
0.008228108,
-0.007305584,
0.046370447,
0.00806531,
-0.00078134815,
-0.00951693,
-0.007210618,
-0.027607916,
-0.036114138,
0.005023013,
0.026400493,
0.015153829,
0.012365905,
0.019413725,
-0.0023181832,
0.0062813098,
0.010066375,
0.009116718,
-0.03245117,
0.016619015,
0.012698285,
0.025030272,
0.0068612793,
-0.03014486,
-0.008268808,
0.05307232,
-0.011667227,
-0.0072445343,
0.02241193,
-0.020010652,
0.0052197278,
-0.008370558,
-0.014977464,
0.02170647,
0.02052618,
0.047482904,
-0.035517212,
-0.021638637,
0.006244002,
0.013030665,
-0.025993498,
0.0063457508,
-0.0005519887,
0.02044478,
0.0095711965,
0.006725614,
-0.017351609,
0.0076515307,
-0.03258684,
0.021163808,
0.01279325,
-0.012379471,
0.017012445,
0.011111,
-0.024460478,
-0.022249132,
-0.032668237,
-0.016931046,
-0.0053859176,
0.017365176,
0.0045414004,
-0.014353403,
-0.0009242208,
-0.007956778,
-0.016062787,
-0.0005532606,
0.006176169,
-0.003288191,
-0.021584371,
-0.018898195,
0.0030982594,
-0.0027811415,
0.013064582,
-0.012901783,
0.0061456445,
0.009890011,
0.011131349,
-0.00060498307,
-0.004276853,
0.02543727,
-0.005738648,
-0.018138468,
-0.015913555,
-0.0016084834,
-0.002068898,
-0.022520462,
0.023795718,
0.17929544,
-0.0125626195,
-0.008295941,
0.007617614,
0.002170647,
-0.018938895,
0.0048568225,
-0.010120641,
-0.009326999,
0.004761857,
0.025016706,
0.01864043,
-0.016754681,
-0.0049857046,
0.013220597,
-0.017636506,
-0.030687522,
-0.00038685848,
-0.030361924,
0.013064582,
-0.0076447474,
-0.0038054155,
-0.0034611644,
-0.0022944417,
0.022208432,
0.018124903,
-0.028679673,
0.004853431,
-0.0100867255,
0.014638301,
-0.0109889,
0.014407669,
-0.014489069,
0.013152764,
0.029575065,
0.006661173,
0.003055864,
0.00031415027,
-0.008526573,
-0.01660545,
-0.005803089,
0.034296222,
-0.004107271,
-0.00460245,
0.013091715,
0.0013897228,
-0.016713982,
-0.019847853,
-0.022208432,
0.011843593,
-0.053859178,
0.044254065,
-0.016768249,
0.024351945,
0.0039444724,
-0.0011802893,
-0.01581859,
0.018192735,
0.011897859,
0.02676679,
-0.011646878,
0.013071365,
-0.031338714,
-0.010907501,
-0.00021505091,
0.050141945,
0.0049890964,
-0.021991367,
0.036711067,
-0.025545802,
0.021842135,
-0.003437423,
-0.001332913,
0.005904838,
-0.013071365,
-0.0065356824,
0.02846261,
0.015235228,
0.017487274,
0.030063462,
-0.0015491297,
0.011077083,
-0.042571813,
0.003437423,
0.016713982,
-0.025423702,
0.017175244,
-0.009978193,
-0.0110838665,
-0.017840005,
0.024663975,
-0.02916807,
-0.018464066,
-0.009008185,
0.0004994184,
0.008485873,
-0.010134208,
0.018179169,
-0.015316628,
-0.024718242,
-0.03728086,
0.077546366,
0.0015864377,
0.010527638,
-0.0011319584,
0.0034238563,
0.00064865034,
0.014014239,
0.0069732033,
-0.0012998445,
0.010459805,
-0.013858224,
0.011687578,
-0.018070636,
0.011789327,
0.010385189,
0.020770378,
-0.048405427,
0.037118062,
-0.02083821,
-0.011714711,
-0.0047245487,
-0.021923535,
0.024067048,
-0.012474437,
0.014991031,
-0.014570468,
0.008587622,
-0.0026166472,
-0.027146654,
-0.0007444641,
0.012413387,
0.0064949826,
0.0012540574,
0.012684719,
-0.017595807,
0.004297203,
0.0032034002,
-0.0037138413,
-0.001677164,
0.0005803937,
-0.0033594153,
-0.0055215834,
0.026997421,
-0.00029125673,
0.0029201985,
0.020688979,
0.016958179,
-0.006213477,
0.0075497814,
-0.021204507,
-0.0013023881,
0.008275592,
-0.024284113,
0.021299474,
-0.026834624,
-0.024134882,
-0.033509362,
-0.0010607342,
-0.011606178,
-0.045149457,
0.005952321,
0.0066747395,
-0.010527638,
-0.011178832,
0.008485873,
-0.17137258,
0.009740778,
0.0010013805,
-0.039885636,
0.019929253,
0.033916358,
0.0032746245,
-0.0062066936,
0.019766454,
-0.0040190886,
0.017365176,
-0.0059421463,
-0.03619554,
-0.04965355,
0.004331119,
0.015208095,
0.007855029,
0.028978137,
0.029412266,
0.008960702,
0.016266286,
-0.019128827,
-0.0004582948,
-0.012454087,
-0.0065187244,
-0.00995106,
-0.00047482902,
-0.0105683375,
-0.0037952405,
-0.007983911,
-0.016931046,
0.01793497,
0.0020638104,
-0.005375743,
0.023185223,
0.005989629,
-0.0016144187,
-0.011843593,
-0.0021960842,
0.018138468,
0.019250926,
0.025383003,
-0.003961431,
0.0075769145,
-0.0011039774,
0.008526573,
0.029303735,
-0.011002467,
0.00804496,
-0.005077279,
-0.003252579,
-0.00078134815,
0.014068506,
0.013159547,
0.035978474,
-0.008112793,
-0.018979594,
0.04289741,
-0.008255241,
0.012013175,
-0.0066713477,
-0.020702546,
0.030823188,
0.0059455377,
-0.0038155904,
-0.011558695,
-0.008682588,
0.011477296,
-0.035978474,
0.0060235453,
-0.0104733715,
0.0036256588,
0.0055860244,
-0.004378602,
0.011490863,
0.019807154,
-0.0035917424,
0.022696827,
-0.010242741,
-0.014801099,
0.0051247617,
0.0066272565,
0.009306649,
-0.0332109,
0.012922132,
-0.010907501,
0.024311246,
0.014543335,
-0.009042101,
-0.0012973007,
0.019969951,
-0.014339836,
0.0097000785,
-0.006389842,
0.026698958,
0.025423702,
0.010161341,
-0.01181646,
-0.009503364,
-0.013552977,
0.013179897,
-0.016252719,
-0.013586894,
0.009299866,
0.029982062,
0.0091235,
0.011151698,
0.00804496,
0.044796728,
-0.017487274,
0.022656128,
0.002280875,
0.017148111,
0.04455253,
-0.006501766,
0.025898531,
-0.013064582,
-0.011728277,
-0.008743637,
-0.013919273,
0.067452855,
0.005070496,
-0.017433008,
0.013729342,
0.0038698565,
0.0033322822,
-0.14347976,
-0.019617222,
0.017812872,
0.022466196,
-0.005935363,
0.021109542,
0.005338435,
0.052448258,
-0.0003402235,
0.017989237,
-0.021462273,
-0.003082997,
0.0019417115,
-0.0023249665,
-0.029330866,
-0.017853571,
-0.0057827393,
-0.018708264,
-0.021190941,
0.03014486,
0.0053621763,
-0.005467317,
0.0015796544,
-0.0035442596,
0.010358056,
0.011850376,
-0.01903386,
-0.0031915293,
0.0039512557,
0.002357187,
-0.006352534,
-0.021095976,
0.02170647,
0.0015669358,
-0.026074897,
0.00553515,
-0.014217738,
0.0009623767,
0.022276266,
0.017663639,
0.00010047721,
-0.01067687,
-0.0020604187,
-0.004378602,
0.010866801,
-0.010921068,
-0.02276466,
0.019128827,
0.0013337608,
0.0037036664,
-0.009157417,
-0.013112064,
-0.024989573,
-0.026332662,
0.033645026,
-0.015967822,
0.004117446,
0.028923871,
-0.011389113,
-0.020458348,
-0.008750421,
-0.005691165,
-0.000009949682,
0.0063220095,
0.010351273,
-0.008865736,
-0.016700415,
-0.032641105,
0.024745375,
-0.031338714,
0.008302725,
0.010975334,
-0.015411594,
-0.0010700611,
-0.009808611,
-0.0025471186,
-0.024514744,
-0.019210225,
-0.003632442,
-0.0183284,
-0.003791849,
-0.026658257,
0.012684719,
-0.025220204,
0.0054367925,
0.019630788,
0.008370558,
0.0017119282,
0.013763258,
-0.0135936765,
0.0009632246,
0.029819263,
0.0007961865,
-0.006484808,
-0.0025539019,
0.01428557,
-0.0368196,
-0.005708123,
0.003568001,
0.01142303,
-0.024039915,
0.0045685335,
-0.051281534,
0.007882162,
-0.003744366,
-0.01687678,
0.007590481,
-0.02154367,
-0.0012354034,
-0.01903386,
-0.0010971943,
0.023198789,
-0.03505595,
-0.009483014,
-0.0013481752,
-0.0015101259,
-0.027350152,
-0.0014210955,
0.022832492,
-0.012847517,
0.026169863,
0.033075232,
-0.028923871,
-0.009001401,
0.0154251605,
-0.006352534,
-0.011314497,
-0.019060994,
-0.015045297,
0.0052502523,
0.0066747395,
-0.020404082,
-0.010371623,
-0.03991277,
-0.012345554,
0.010364839,
-0.022737527,
-0.02064828,
-0.00010969822,
0.02865254,
0.014963898,
0.0405097,
-0.010893934,
-0.05415764,
-0.021299474,
0.00082967896,
-0.015845723,
0.000023410237,
-0.031284448,
0.0015610005,
0.0011624832,
-0.017731473,
0.039532907,
0.014733266,
0.0025742517,
-0.016632583,
-0.02579,
0.0061422526,
0.0040021306,
-0.012698285,
-0.0053791343,
-0.010405539,
0.024379078,
0.013057798,
-0.0076922304,
-0.0027285712,
-0.002423324,
-0.013132414,
-0.006528899,
-0.009042101,
0.008221325,
-0.015723623,
-0.021652203,
0.036114138,
0.009462664,
-0.0011421334,
0.007909295,
0.0076922304,
-0.008112793,
-0.005131545,
-0.008038177,
0.013959973,
0.010866801,
-0.00082035194,
0.0018755747,
0.03234264,
-0.00006343419,
0.006549249,
-0.007814329,
0.022506896,
-0.009713645,
0.017772172,
0.008723288,
0.010425889,
0.008940352,
0.018260568,
0.012711851,
0.0013057798,
-0.003408594,
0.011646878,
0.0044667847,
0.009856094,
-0.005996412,
-0.0037952405,
-0.007013903,
-0.020200584,
-0.0077329297,
0.018898195,
-0.024826774,
-0.017867139,
0.006064245,
0.0033984191,
0.0036256588,
0.0049958797,
0.0015906772,
-0.004928047,
-0.023185223,
0.0062914845,
-0.0030796053,
-0.019142393,
-0.0067968383,
0.01250157,
0.03269537,
0.01954939,
0.018423365,
-0.008038177,
0.017243076,
0.008377341,
0.010961767,
-0.04227335,
0.013708992,
-0.011857159,
0.016103487,
-0.018938895,
-0.04710304,
-0.00657299,
-0.020661846,
0.006440717,
-0.000050530074,
0.02237123,
-0.005355393,
0.07613544,
0.02056688,
-0.0024351946,
0.008289158,
-0.025328737,
0.032749638,
-0.0010658216,
0.0040665716,
-0.00885217,
-0.028164145,
0.016808948,
-0.01585929,
0.023456555,
0.0018484415,
-0.009374482,
0.023348022,
-0.0047279405,
0.03568001,
-0.02747225,
-0.02402635,
0.022235565,
-0.022194866,
0.010453022,
-0.0034357272,
-0.046370447,
0.0106972195,
0.03700953,
-0.012895,
0.013627593,
-0.013491928,
0.010120641,
-0.0031559172,
-0.033943493,
0.010453022,
0.012942483,
0.008268808,
-0.013661509,
-0.0118232425,
0.0017178636,
0.021014577,
0.021299474,
-0.012576186,
-0.010276657,
-0.032071307,
0.0057657813,
0.002190997,
0.00020180234,
0.0053689596,
-0.004599058
] |
T cell-specific deletion of Blimp-1 causes abnormal T cell homeostasis and function, leading to spontaneous, fatal colitis in mice. Herein we explore the role of Blimp-1 in Th1/Th2 differentiation. Blimp-1 mRNA and protein are more highly expressed in Th2 cells compared with Th1 cells, and Blimp-1 attenuates IFN-gamma production in CD4 cells activated under nonpolarizing conditions. Although Blimp-1-deficient T cells differentiate normally to Th2 cytokines in vitro, Blimp-1 is required in vivo for normal Th2 humoral responses to | [
-0.035191685,
-0.004441765,
-0.009792297,
-0.014316378,
-0.01191934,
0.012037875,
-0.025814261,
0.021823587,
-0.0050311466,
-0.016950486,
0.02262699,
-0.007342577,
0.015185635,
0.005544798,
-0.015251487,
0.012577867,
0.027315702,
0.013368099,
-0.019070944,
0.01920265,
-0.0404599,
0.01704268,
-0.012512014,
-0.01995337,
-0.017398285,
-0.005650162,
0.027263021,
-0.046834446,
-0.023153812,
0.0033979996,
0.023022106,
-0.017925106,
-0.016436836,
0.008185492,
0.0048961486,
-0.030318586,
0.0021797246,
-0.014685154,
0.023891361,
-0.018096324,
0.010279608,
0.01896558,
-0.009555228,
0.021889439,
0.0034012923,
0.008442317,
0.012676646,
0.0069474606,
0.004668957,
-0.013960774,
0.01925533,
0.016502688,
-0.019505572,
0.00071738294,
-0.030213222,
-0.0045570075,
-0.007757449,
-0.0018586926,
-0.011353007,
-0.010378387,
-0.0013623278,
-0.0048731,
-0.0127029875,
0.0021418594,
0.007566476,
0.002808618,
0.0014586374,
-0.0036712885,
0.001570587,
-0.0075401347,
0.0530246,
0.036956538,
-0.015857331,
0.005281387,
0.014395402,
0.0013549194,
-0.02630157,
0.009298402,
-0.029238602,
0.0062494217,
0.029976152,
-0.010898623,
-0.006690635,
0.01652903,
0.022245044,
-0.0032712333,
-0.0036350694,
0.023061618,
0.005831257,
0.014540277,
0.02382551,
0.025221586,
0.0345595,
0.037377995,
-0.005989304,
-0.0019261916,
-0.008205247,
0.037167266,
-0.0016553724,
-0.028817145,
0.0041684764,
-0.0065622223,
-0.015488557,
-0.016621223,
-0.035876554,
0.001051997,
-0.0012544941,
-0.019571424,
0.02042751,
0.0005050079,
-0.008593778,
0.01652903,
-0.009812053,
-0.05763429,
0.014724665,
0.017622184,
-0.0025633166,
0.020519704,
-0.015027587,
-0.011636173,
0.013565658,
0.0074545266,
0.010450824,
-0.021942122,
0.02140213,
0.0062889336,
-0.011076425,
-0.020585556,
-0.01705585,
-0.0077969604,
0.015975866,
0.045859825,
0.021349447,
-0.0061440575,
0.00316093,
-0.0029353844,
-0.020124586,
-0.006756488,
-0.0045438367,
-0.0014528753,
-0.011227886,
0.037114587,
0.0010808075,
-0.0006095491,
0.005640284,
0.012176165,
0.01727975,
-0.0009145295,
-0.012452747,
0.020480191,
-0.022929912,
-0.02215285,
-0.0037898233,
-0.01191934,
0.026169866,
0.02844837,
-0.020559216,
0.038457982,
-0.010654968,
-0.011076425,
0.0041585984,
-0.01920265,
0.018425588,
0.014527107,
0.028790804,
0.025853772,
-0.017187556,
0.020796284,
-0.014237355,
-0.009074503,
0.025616704,
0.026630834,
-0.013723704,
0.024167944,
-0.009581569,
0.020901648,
-0.017793402,
0.015449045,
-0.008659631,
-0.029528353,
-0.024167944,
0.043173034,
0.01967679,
0.008001104,
-0.022007974,
0.004234329,
0.022969425,
-0.0073623327,
-0.008152565,
-0.010082049,
0.012933471,
0.013960774,
-0.0010445885,
-0.0163183,
-0.6199637,
-0.03158296,
0.035428755,
0.012512014,
-0.018702168,
0.041803297,
0.009864735,
-0.006111131,
-0.024879152,
0.025616704,
-0.009568398,
0.009897661,
0.0039676256,
-0.0123473825,
-0.02308796,
-0.025708897,
0.005976133,
-0.012472503,
0.0015467155,
-0.021599688,
-0.0048961486,
-0.011965437,
-0.0006284818,
0.029607376,
-0.016476348,
0.0097462,
0.013210053,
-0.020243121,
-0.014751006,
0.033374153,
-0.016331472,
0.045412026,
-0.0051365113,
-0.012116898,
0.044885203,
0.013973944,
-0.022113338,
0.018175347,
0.016094401,
0.020954331,
0.010852526,
-0.0032975744,
0.026788881,
-0.0017022925,
-0.015857331,
0.012716157,
-0.010892037,
0.017358774,
0.024036238,
-0.01326932,
0.0004815479,
0.010687894,
-0.00029139823,
0.010859111,
0.029317625,
0.0132759055,
0.03018688,
-0.0012569636,
0.020387998,
-0.006364664,
-0.018715339,
0.015975866,
-0.025129393,
-0.009976685,
-0.011227886,
0.015290999,
-0.014777347,
-0.006927705,
0.019360695,
0.006302104,
0.0050048055,
0.022771865,
-0.0042244513,
0.014790518,
0.0116888555,
0.051944613,
-0.0055777244,
0.007105507,
-0.0053933365,
-0.0012882436,
-0.001103856,
-0.00179284,
-0.012274944,
-0.009186452,
0.02871178,
0.011412274,
0.0032860502,
0.032267828,
-0.024009896,
0.01727975,
0.024865981,
0.011458371,
0.0046294453,
-0.033979997,
-0.045912508,
0.012716157,
-0.0056830887,
0.0010808075,
-0.007889154,
-0.012202507,
-0.01580465,
0.007948422,
0.028632756,
0.009015235,
0.014026627,
0.022692842,
-0.014303208,
-0.0057917456,
0.02506354,
-0.008192076,
0.0009770895,
-0.0006873376,
0.002471123,
-0.004254085,
0.011879828,
-0.017740719,
0.027842524,
0.015541239,
-0.0050969995,
-0.0062593,
0.019571424,
-0.009871321,
0.016463177,
-0.012874204,
0.0004659079,
0.028527392,
0.019426549,
-0.004415424,
0.007849643,
-0.01253177,
0.0026670345,
0.005008098,
0.017358774,
-0.019228991,
0.027394727,
-0.00089312735,
0.019110456,
0.005245168,
-0.00419811,
-0.025853772,
-0.033374153,
-0.028053254,
0.010299363,
-0.023048447,
-0.0126173785,
0.0132759055,
0.011379348,
-0.0133944405,
0.022521626,
0.009041577,
0.016989999,
0.0015886965,
-0.00407299,
-0.0056929663,
0.03890578,
-0.0035823872,
-0.017332433,
-0.013420782,
-0.000059267437,
-0.016410494,
-0.00058444275,
0.01849144,
0.03182003,
0.02262699,
-0.0065227104,
-0.014540277,
-0.003747019,
0.0007536019,
-0.010753747,
-0.044384725,
-0.00289258,
-0.004270548,
-0.009416937,
0.019584594,
0.0045372513,
0.001404309,
-0.011399103,
-0.0119259255,
-0.011346421,
-0.002492525,
0.0020858846,
-0.0072635533,
0.0017434504,
-0.009667178,
0.026933758,
-0.00032823457,
0.022547966,
0.0047348095,
0.010562774,
0.036192648,
-0.009219379,
0.014184673,
-0.023496246,
0.023246005,
0.0013211699,
-0.030055175,
0.020322146,
0.0049982206,
-0.0011771171,
0.03187271,
-0.01275567,
-0.009199623,
-0.0020348486,
-0.013150785,
0.024220625,
-0.0330844,
-0.012841278,
-0.020572385,
-0.010674723,
-0.00024530134,
-0.009568398,
0.0011623002,
0.00029654297,
0.006012352,
0.019821664,
-0.010589115,
-0.02994981,
-0.014711495,
0.004754565,
-0.024997687,
-0.016107572,
0.01044424,
0.0075928173,
-0.0060880827,
-0.007375503,
0.014303208,
0.015027587,
0.007224042,
-0.014013456,
-0.008165736,
0.0019903982,
0.001410071,
0.014922223,
0.0025830725,
0.0008429146,
-0.016226107,
0.013552487,
-0.010990817,
0.03387463,
0.0043923757,
-0.01020717,
0.01996654,
0.0008297441,
0.007322821,
-0.01776706,
-0.022758696,
0.017437797,
0.008613534,
-0.009752786,
0.012130069,
-0.032662943,
-0.0031741005,
-0.0015763491,
-0.020374827,
-0.010602286,
-0.012801766,
-0.00962108,
0.0035823872,
0.046333965,
0.020216782,
0.011524224,
-0.025537679,
0.018135834,
-0.0066939276,
0.00079475984,
-0.0059991814,
-0.012492258,
-0.00511017,
-0.027052293,
-0.008705728,
-0.032979034,
-0.00015917834,
0.022271385,
-0.039748695,
0.026459618,
0.025537679,
0.010246681,
0.021336276,
0.0128873745,
0.011017158,
-0.008699142,
-0.035191685,
0.01947923,
0.026354253,
-0.018017301,
-0.013552487,
-0.029133238,
-0.01584416,
0.009311573,
0.010167658,
-0.014513937,
0.014263696,
0.015119782,
0.005735771,
0.014250525,
-0.013210053,
0.02672303,
-0.018333394,
0.018820703,
0.011451785,
0.014329549,
-0.01436906,
-0.01874168,
0.00331733,
0.012222262,
0.0063053966,
-0.005103585,
-0.0216392,
-0.02166554,
-0.013539316,
-0.006670879,
-0.026314741,
0.00559748,
-0.0074808677,
0.0065622223,
-0.0004856637,
0.03550778,
0.00331733,
0.0063712494,
0.008047201,
-0.032083437,
-0.020585556,
-0.0037568968,
0.0032201973,
0.0038359202,
0.027842524,
0.0030868456,
0.019887518,
-0.010602286,
-0.0034737303,
-0.0034539744,
-0.021230912,
0.024773788,
-0.018056812,
-0.016937315,
-0.011813976,
-0.004349571,
-0.013565658,
-0.00705941,
0.0028497758,
-0.0058115013,
-0.01845193,
0.03168832,
0.0022620405,
0.0041223792,
0.0138158975,
0.01204446,
0.025616704,
0.01729292,
-0.014487595,
0.010391557,
0.01924216,
0.0058279647,
-0.005696259,
-0.009673763,
0.00608479,
0.0015384839,
-0.009008651,
-0.012426406,
-0.026222548,
-0.0057390635,
0.02382551,
-0.004152013,
-0.009067917,
-0.004171769,
0.012637135,
-0.0021007014,
-0.016015379,
-0.03458584,
-0.013802728,
-0.013098103,
0.027447408,
-0.007033069,
-0.020308975,
0.03505998,
-0.018688997,
-0.0016290314,
-0.01775389,
-0.0011762939,
0.00913377,
0.010622041,
0.006789414,
0.0062362514,
-0.016858293,
-0.008909871,
-0.03843164,
0.0028152033,
0.00028954612,
0.0010281254,
-0.020743603,
-0.006002474,
-0.00231143,
-0.01751682,
-0.023338199,
0.008001104,
-0.020796284,
-0.021191401,
0.00085443887,
0.010022782,
0.024905493,
0.009041577,
-0.011227886,
-0.004721639,
0.008554267,
0.0007852935,
-0.027447408,
0.008969138,
-0.020374827,
0.013908092,
0.0072437976,
0.00016031018,
-0.03113516,
-0.028184958,
0.00056098273,
0.004234329,
-0.006394298,
0.011451785,
-0.00020846498,
-0.001715463,
0.016463177,
0.021823587,
0.037272632,
0.008080127,
-0.0128544485,
-0.010503506,
-0.0072174566,
-0.039748695,
0.0047051758,
-0.013894921,
-0.015883673,
0.02020361,
0.0056830887,
-0.0011573613,
-0.015304169,
-0.008942798,
-0.009877906,
-0.0051365113,
-0.019650448,
0.023456734,
0.03424341,
-0.005669918,
0.022508455,
0.029581036,
-0.024286479,
-0.010292778,
-0.033716585,
-0.0015195512,
0.019149967,
-0.01240665,
0.00814598,
-0.013440537,
-0.02482647,
-0.01920265,
0.00054657744,
-0.013368099,
0.0034737303,
0.01925533,
-0.0038293349,
-0.031319547,
0.0150671,
0.019545084,
0.017253408,
-0.009041577,
-0.033979997,
-0.008626704,
0.024536718,
0.004668957,
0.0024217332,
0.015607092,
-0.031767346,
-0.0037503117,
0.0058279647,
0.025168905,
0.015264657,
0.010661554,
0.009614496,
-0.01289396,
-0.0022110047,
-0.0016989998,
-0.027868865,
0.003918236,
-0.0049060266,
0.026933758,
0.041697934,
0.0056336992,
-0.0012651951,
0.057528924,
0.013842239,
0.01191934,
0.012729328,
-0.010826185,
0.00693429,
-0.012689817,
0.029739082,
-0.0056468695,
-0.014513937,
0.029396648,
-0.022047486,
0.0037042147,
0.023548927,
-0.026011819,
-0.006555637,
0.026341083,
-0.022231873,
-0.025353292,
0.007395259,
-0.007790375,
0.0041651838,
-0.03471755,
-0.013829068,
0.02115189,
0.016252449,
0.006094668,
0.0301342,
0.007395259,
-0.021323107,
0.035639483,
0.0011310203,
0.005199071,
0.0022356994,
-0.009364255,
0.011208131,
0.0017138167,
0.0060452786,
-0.007105507,
-0.013591998,
-0.019808494,
-0.003855676,
0.01460613,
-0.0016051597,
-0.024273308,
-0.001275073,
-0.01033229,
-0.0027427652,
-0.031978074,
-0.024892323,
-0.0073359916,
-0.032768305,
-0.0042639626,
-0.009897661,
-0.023996726,
0.012986153,
-0.00717136,
-0.0301342,
0.010266437,
-0.02285089,
0.017121704,
-0.013591998,
0.023008935,
0.03329513,
-0.0106088715,
-0.01579148,
-0.018781193,
-0.011076425,
0.0011771171,
0.024931835,
0.02921226,
-0.009627665,
-0.00985815,
0.011728367,
0.0010182475,
-0.0015088501,
-0.01436906,
-0.0045438367,
-0.0043034744,
-0.008073542,
-0.022258215,
-0.025195245,
-0.023443563,
0.013302247,
-0.0028168496,
0.019070944,
-0.008890116,
-0.011708612,
0.0015919892,
-0.009706689,
-0.004096038,
-0.008343538,
-0.0036054356,
-0.014553448,
0.010602286,
-0.03598192,
-0.016845122,
-0.006348201,
0.024602572,
0.026933758,
0.024405014,
0.022692842,
-0.0019772276,
0.01925533,
0.0015104965,
0.0072306274,
-0.021612858,
0.045069594,
-0.0039248215,
-0.0025682556,
-0.013987115,
-0.0006235428,
0.01204446,
-0.029054213,
-0.0003477846,
-0.009779127,
-0.018860215,
-0.0044812765,
0.035692167,
0.013512976,
-0.01023351,
0.014961735,
-0.03229417,
-0.017121704,
-0.01921582,
-0.029976152,
-0.01130691,
-0.033479515,
0.012650305,
0.00067910604,
-0.0012882436,
-0.003845798,
0.014909053,
0.010365216,
0.0033008668,
0.039564308,
-0.01533051,
0.010240096,
0.005064073,
0.0118073905,
-0.018188518,
0.009397182,
-0.013236394,
-0.01157032,
-0.0037634822,
-0.02285089,
-0.04788809,
-0.013750046,
-0.008356708,
0.03334781,
0.0167661,
-0.0037634822,
0.011860073,
0.018188518,
0.00705941,
-0.006032108,
-0.012393479,
0.0075269644,
-0.025629874,
-0.017398285,
-0.0069935573,
0.018069983,
-0.0032448922,
0.011372763,
-0.0034473892,
-0.0068289256,
0.000668405,
-0.032715626,
-0.009963514,
-0.011820561,
0.013591998,
-0.00449774,
-0.007375503,
0.0062263734,
-0.011649344,
0.010536433,
0.000515709,
-0.007322821,
-0.0214153,
-0.0044812765,
-0.021849928,
0.022916742,
-0.00048731003,
-0.018096324,
-0.004445058,
-0.029264944,
-0.005906988,
-0.0049159047,
-0.021797245,
0.023338199,
-0.03018688,
0.007289895,
-0.0037437263,
-0.008514755,
-0.028764462,
-0.009660592,
0.002026617,
-0.00028975192,
0.0057555265,
0.029976152,
-0.013723704,
0.004096038,
-0.009449864,
0.010661554,
0.007928666,
-0.032741968,
-0.004119087,
0.00064617966,
0.019755812,
0.0045998115,
-0.013052006,
-0.044015948,
0.029027874,
-0.0014586374,
0.0061275945,
0.040802337,
-0.038695052,
0.018847045,
-0.022271385,
0.0007959946,
0.0017187557,
0.021086037,
-0.0031691615,
-0.020493362,
-0.00814598,
-0.0001049013,
-0.007612573,
-0.0017895473,
-0.006437102,
0.0034704376,
0.00046385,
-0.013315417,
-0.007033069,
-0.03458584,
-0.023785997,
-0.023153812,
0.013453708,
0.0194924,
-0.017371943,
0.013460293,
-0.004741395,
-0.013117859,
-0.029317625,
-0.0030242857,
-0.006012352,
0.015462215,
-0.010009611,
0.0036811663,
-0.024549888,
0.017661696,
-0.0025056954,
-0.020058734,
-0.0060255225,
-0.033927314,
0.028105935,
-0.04359449,
0.015870502,
-0.0059036952,
-0.014645642,
-0.0058082086,
-0.004152013,
-0.009660592,
-0.015962696,
0.00485993,
-0.0066379528,
-0.005857598,
0.0023970385,
0.0070725805,
0.0041651838,
-0.010911793,
-0.002099055,
-0.014158332,
-0.006647831,
0.0079747625,
0.19492401,
-0.0364824,
0.015053929,
0.014711495,
0.0030983698,
-0.015225146,
-0.01130691,
-0.003819457,
-0.0011869951,
-0.009094259,
0.01205763,
0.001668543,
0.016094401,
0.0017664989,
0.026064502,
-0.02942299,
-0.03916919,
-0.022468943,
-0.014711495,
-0.02627523,
-0.004754565,
-0.012083972,
0.025708897,
0.0023410637,
0.03234685,
0.021560175,
-0.011003987,
0.01483003,
0.014382231,
-0.0055415053,
-0.054842133,
-0.0006577039,
-0.005008098,
-0.008047201,
0.0021204571,
0.019387037,
-0.049995374,
-0.014066138,
-0.0021632614,
-0.0038787245,
-0.031187842,
0.016673906,
-0.0065490515,
0.018346565,
-0.011576906,
0.017819742,
0.0058180867,
0.00924572,
0.0024381964,
0.00056098273,
-0.032320507,
0.007467697,
0.008942798,
0.021428471,
0.0030028834,
-0.009924003,
0.022034315,
-0.013908092,
0.0064766137,
0.05033781,
-0.016568542,
0.024642082,
-0.02065141,
0.04356815,
-0.0064140535,
0.01970313,
-0.023996726,
-0.015080269,
0.0089888945,
-0.03574485,
0.025024028,
-0.015396363,
-0.02844837,
-0.015383192,
-0.00036898095,
-0.015607092,
0.0054756524,
0.018583633,
0.00035869147,
0.02115189,
0.008929627,
0.01070765,
-0.03843164,
-0.009054747,
0.006647831,
-0.023022106,
0.037641406,
-0.003908358,
-0.029739082,
-0.009495961,
-0.008073542,
-0.0037601895,
0.00028934033,
0.010213755,
0.005748941,
-0.00792208,
-0.00950913,
0.02530061,
-0.009686933,
-0.009673763,
-0.018280711,
0.07897057,
0.020216782,
-0.0065161255,
-0.009917418,
0.019571424,
0.0033387323,
-0.0004379205,
-0.023061618,
-0.019597765,
0.010918379,
-0.03037127,
0.010951305,
0.009278647,
-0.004280426,
0.023983555,
0.0083632935,
-0.0018932653,
0.03358488,
0.004231036,
-0.0034638525,
-0.027447408,
0.012024704,
0.03379561,
-0.018096324,
0.00426067,
-0.045412026,
0.020019222,
-0.009146941,
-0.028422028,
0.005373581,
-0.010371801,
0.0041059162,
0.024655253,
0.011135693,
0.0020825919,
0.0019624108,
-0.041460864,
-0.021942122,
-0.0022422846,
-0.019228991,
0.0016043365,
-0.0022422846,
-0.015607092,
0.015475386,
0.0017006461,
0.049073435,
0.009489375,
-0.00864646,
-0.014961735,
-0.011504468,
-0.017701207,
-0.03113516,
-0.031530276,
0.023680633,
-0.030608337,
0.005933329,
-0.036798492,
0.0012322688,
0.0030572119,
-0.015343681,
0.03650874,
0.0025172196,
0.00031135982,
-0.0020496654,
-0.020862138,
-0.16373616,
0.0150671,
0.007981348,
0.00092111476,
0.024945006,
0.00778379,
-0.015343681,
-0.01265689,
-0.018754851,
0.0125844525,
0.036561422,
0.004876393,
-0.024181115,
-0.020295804,
-0.0029041043,
-0.0036910442,
-0.04206671,
0.031951733,
0.02262699,
0.010319119,
0.028105935,
-0.03137223,
0.0030917847,
-0.023325028,
-0.0017220483,
0.014013456,
0.016687077,
0.009212794,
-0.011063254,
-0.026341083,
-0.01729292,
-0.0063086892,
0.0428306,
0.009726445,
0.03042395,
-0.0046623717,
-0.014131991,
-0.035244368,
0.011056669,
0.035455097,
0.045385685,
0.017846083,
0.0020578972,
-0.004333108,
-0.038853098,
0.03627167,
0.0029320917,
0.011155449,
0.043094013,
-0.023996726,
0.026051331,
-0.008356708,
0.0231143,
0.02871178,
0.023246005,
-0.0004601458,
0.00325477,
0.01533051,
-0.010977646,
0.0028744705,
-0.02627523,
-0.014316378,
0.0150671,
0.008277685,
0.0036712885,
-0.026933758,
-0.0010618749,
0.013789557,
-0.010562774,
0.0051233405,
-0.0045273737,
-0.014790518,
0.023338199,
0.0031214182,
0.013262735,
0.01133325,
-0.018715339,
0.0015047344,
0.00069762714,
0.0006293049,
-0.015435874,
0.00084703043,
-0.031214183,
-0.009239134,
-0.0071120923,
0.025708897,
-0.001787901,
0.025247928,
0.00013242567,
-0.010687894,
0.014237355,
-0.030634679,
-0.0061539356,
-0.01584416,
0.010615456,
0.04130282,
-0.004777614,
-0.01850461,
-0.004461521,
0.0044253017,
0.015975866,
-0.019373866,
0.007250383,
-0.00426067,
0.036851175,
0.0014067785,
-0.02044068,
0.010299363,
0.03624533,
-0.008732069,
0.009996441,
0.0045306664,
0.015699286,
0.010628627,
0.0039511626,
-0.013420782,
-0.010147902,
-0.011563735,
0.019571424,
-0.04312035,
0.07765351,
-0.0075796465,
-0.01204446,
0.022060657,
-0.01457979,
-0.022574307,
-0.12970349,
-0.03816823,
0.0245894,
0.012946642,
-0.009179867,
-0.010984232,
-0.0029370307,
0.028184958,
-0.018162176,
0.023325028,
-0.02456306,
-0.006463443,
-0.007441356,
-0.018860215,
0.00717136,
0.023166982,
0.014487595,
-0.004576763,
-0.014895882,
0.012024704,
-0.005083829,
-0.020743603,
0.0071647745,
-0.019979712,
0.0027855695,
-0.014211014,
-0.037509702,
0.026183037,
0.0056863814,
0.0037272633,
0.007329406,
0.0040137223,
0.02992347,
0.014066138,
0.0012133361,
0.012867619,
0.0045109103,
-0.019808494,
0.028158618,
-0.008574022,
-0.015396363,
0.0065786853,
-0.0057818675,
-0.016752928,
-0.0067334394,
-0.011629588,
0.008126224,
0.0045570075,
0.028790804,
-0.021454811,
-0.02162603,
-0.039537966,
-0.04936319,
-0.008587193,
0.005357118,
0.008896701,
0.03187271,
0.02602499,
-0.012940057,
0.0077772047,
0.011906169,
0.0016504334,
-0.019281672,
0.010575945,
0.027552772,
-0.021533836,
-0.0026077672,
-0.04593885,
0.02944933,
-0.040486243,
-0.012149825,
0.004958709,
-0.0070001427,
-0.009588154,
-0.0051891934,
0.010780088,
-0.0025155733,
0.0073886737,
0.007803546,
-0.0076059876,
-0.018412417,
-0.013552487,
0.039248213,
-0.00073713873,
0.037615065,
0.011122522,
0.015383192,
0.008132809,
0.015053929,
-0.005913573,
0.008225003,
0.04672908,
0.019176308,
-0.017819742,
-0.0077508637,
0.00322349,
-0.0027905086,
0.0018356442,
0.035139006,
0.007349162,
0.001191934,
-0.019373866,
-0.056264553,
0.019518742,
-0.017477307,
0.0004938953,
0.016370984,
-0.02336454,
0.007303065,
-0.032926355,
0.000979559,
0.027025951,
-0.0016594882,
0.02797423,
-0.015198804,
0.0010248327,
-0.012861034,
-0.0041026236,
0.029343966,
0.0065885633,
0.007803546,
0.029343966,
0.0032317215,
-0.0027197169,
0.0042507923,
0.0054098,
0.008876945,
-0.010648383,
-0.0015039112,
0.020387998,
0.003720678,
0.009239134,
0.016186595,
-0.025616704,
-0.022482114,
0.010714236,
-0.038299933,
-0.008310611,
0.0068947785,
0.022231873,
0.03089809,
0.029633718,
0.005870769,
-0.02747375,
0.036719467,
-0.009502546,
-0.009779127,
-0.014685154,
-0.04717688,
0.007790375,
0.016687077,
-0.022534797,
0.060531806,
0.0014092479,
0.018530952,
-0.029765423,
-0.005906988,
-0.0035000714,
0.0025155733,
-0.019992882,
-0.0033815366,
0.0024908786,
0.020625068,
0.021428471,
0.019334355,
0.007981348,
-0.014527107,
-0.014276867,
-0.017925106,
-0.0022175899,
-0.02162603,
-0.025379634,
-0.019834835,
0.013710533,
0.012913716,
-0.008811092,
0.036824834,
0.005752234,
-0.02627523,
0.00682234,
-0.017398285,
0.037377995,
0.015435874,
-0.0014578142,
-0.024181115,
0.013111274,
0.041671593,
-0.0051793153,
-0.0064239316,
0.0073359916,
-0.0015672945,
0.0072174566,
-0.016489517,
0.0060485713,
0.018320223,
0.009285232,
0.024418185,
0.023891361,
0.010990817,
0.018623145,
-0.01901826,
0.043094013,
-0.00792208,
-0.002663742,
-0.016041718,
-0.0080932975,
-0.008764995,
0.020822626,
-0.027157657,
-0.056106508,
-0.006167106,
-0.0025353292,
-0.009640836,
0.0016973536,
-0.0020644823,
0.009851565,
-0.037272632,
0.011827146,
0.0032070267,
0.016739758,
0.003921529,
0.018596804,
0.015317339,
-0.009311573,
-0.00729648,
-0.02190261,
-0.015778309,
0.0034243409,
0.02728936,
-0.018122666,
0.009891077,
-0.0167661,
0.030740043,
-0.0018274126,
-0.04277792,
-0.0043396936,
0.004336401,
-0.007467697,
0.03113516,
0.02677571,
-0.001285774,
0.074071124,
-0.011517638,
-0.0013886689,
-0.010543019,
-0.027947888,
0.010740576,
0.00864646,
0.006186862,
0.009838395,
-0.015989037,
0.02508988,
0.0016364398,
0.032083437,
-0.028632756,
-0.018662658,
0.016700247,
-0.010990817,
-0.0074545266,
-0.002103994,
-0.010213755,
0.015488557,
-0.022534797,
0.0017648526,
0.009054747,
-0.04380522,
-0.009956929,
0.019110456,
0.0092588905,
-0.01070765,
-0.019360695,
0.020269463,
-0.010892037,
-0.04883637,
-0.01925533,
0.02844837,
-0.011036914,
-0.004540544,
-0.014751006,
0.019992882,
0.004994928,
-0.0051891934,
0.028817145,
-0.026933758,
0.00008051522,
0.00016422018,
-0.0148432,
0.0011260813,
-0.014039797,
-0.014961735
] |
Allergic asthma is a T helper type 2 (T(H)2)-dominated disease of the lung. In people with asthma, a fraction of CD4(+) T cells express the CX3CL1 receptor, CX3CR1, and CX3CL1 expression is increased in airway smooth muscle, lung endothelium and epithelium upon allergen challenge. Here we found that untreated CX3CR1-deficient mice or wild-type (WT) mice treated with CX3CR1-blocking reagents show reduced lung disease upon allergen sensitization and challenge. Transfer of WT CD4(+) T cells into CX | [
-0.023995947,
0.025187885,
-0.015377316,
-0.017525423,
-0.0095879,
0.0052392897,
-0.017001495,
-0.003467755,
-0.013818626,
-0.016805021,
-0.00582871,
-0.020551113,
0.0002041481,
0.007976819,
-0.014106788,
0.0012959056,
0.036858402,
0.0010028328,
-0.014172278,
-0.01438185,
-0.028789897,
0.0066178776,
-0.014879582,
-0.015757164,
-0.006896215,
-0.006987903,
0.02544985,
-0.045398444,
-0.014355654,
-0.017931469,
0.004417376,
0.008042309,
-0.021140534,
0.007695207,
-0.0018533987,
-0.01718487,
0.008029211,
0.0031108283,
0.018154139,
0.001984381,
0.021494186,
0.008454904,
0.0066342507,
0.02516169,
0.012718376,
0.00365113,
0.025122395,
-0.03570576,
-0.002991307,
-0.005429214,
0.019071015,
0.0090901675,
-0.019149603,
-0.01334709,
-0.035103243,
-0.0154952,
0.0014350743,
0.009011579,
0.0073284563,
-0.02721811,
-0.018560184,
0.018429201,
-0.024244813,
0.0062445784,
-0.002855413,
0.023773277,
-0.008677574,
0.032509793,
0.005059189,
-0.01740754,
0.031095184,
0.0059498684,
-0.008736515,
-0.010491678,
0.024454385,
0.0055732946,
-0.009705784,
0.0035758151,
-0.025567735,
-0.0009127825,
0.017734995,
-0.018245826,
-0.02389116,
0.053100202,
0.017106282,
0.013170265,
0.0037362685,
0.006084125,
-0.015364217,
-0.005635511,
0.00723022,
-0.015429708,
0.0050690128,
0.024821134,
0.011225178,
0.005622413,
0.0027391661,
0.015207038,
-0.007544577,
-0.031068988,
0.003516873,
-0.00586473,
-0.02678587,
-0.012790416,
-0.03649165,
0.0047382824,
-0.0035823644,
0.012351626,
0.015521396,
-0.014185376,
-0.0014760061,
0.020826176,
0.007950623,
-0.05485536,
0.031147577,
-0.0032074277,
0.008271528,
0.0037297194,
-0.0116443215,
-0.013857922,
0.0037493666,
0.031619113,
0.012476059,
-0.003906545,
0.022581339,
0.015888145,
-0.027165717,
-0.017656406,
-0.0107143475,
-0.0038967216,
0.027768236,
0.021625169,
0.02396975,
0.019385371,
-0.003562717,
0.02634053,
-0.029392416,
0.017957665,
-0.018533988,
-0.009201502,
-0.007125434,
0.031199971,
0.003998233,
0.004764479,
0.003998233,
0.0294972,
0.048122875,
-0.0055798437,
0.0040211547,
0.0184423,
-0.0025394182,
-0.013491171,
0.0016683863,
-0.008232234,
0.015508298,
0.022594437,
-0.01571787,
0.021965722,
-0.034395937,
-0.005812337,
-0.0065785833,
-0.02573801,
0.026982343,
-0.018573282,
0.030571256,
0.0184423,
0.008382863,
0.014277064,
-0.0030436998,
0.0037821122,
-0.00685692,
0.012751121,
0.00047071744,
0.02831836,
0.010124927,
0.007531479,
-0.0029078058,
0.007511832,
-0.009869512,
-0.008788909,
-0.009594449,
0.018468495,
0.01747303,
-0.0339244,
-0.008251881,
0.007092688,
0.016543057,
-0.0012770769,
0.0019532726,
-0.03009972,
-0.009456918,
0.035417598,
-0.0031321128,
-0.033950597,
-0.6375168,
-0.02567252,
0.017224165,
0.002131736,
0.01393651,
0.035758153,
-0.0018403005,
-0.00010765103,
-0.026130958,
0.013091675,
0.0014465351,
0.0014882857,
0.012882103,
-0.0176957,
-0.004957678,
-0.019725926,
0.010242811,
-0.004803774,
0.019804515,
0.00047931314,
0.012462961,
-0.0046662423,
-0.0082780775,
0.017093183,
0.007393948,
-0.002002391,
0.0021464715,
-0.042674016,
-0.0041488623,
0.021507284,
-0.0023986122,
0.0287637,
0.0102559095,
0.0049773254,
0.05962312,
-0.0039720363,
-0.012508804,
0.018848345,
0.035417598,
0.031854883,
-0.01320301,
0.0042831195,
0.022397963,
0.0033596945,
-0.020197462,
0.02685136,
-0.0018615851,
0.029863952,
0.02603927,
0.00046744288,
-0.005134504,
-0.0066113286,
-0.03717276,
0.012849358,
0.013726939,
-0.0026409295,
0.02161207,
-0.012849358,
-0.0024690153,
-0.010668504,
-0.018638773,
0.028947076,
-0.03148813,
-0.019581845,
0.014945074,
0.0048659905,
-0.008756163,
0.008494198,
-0.0010593189,
0.017486129,
-0.009679588,
0.027401485,
-0.007014099,
0.02293499,
-0.0012115857,
0.029418612,
-0.0048659905,
-0.020970257,
-0.023838768,
-0.0030862691,
0.0055896672,
0.006581858,
-0.0008018569,
0.0010200242,
0.03444833,
-0.01231888,
-0.013857922,
0.0199224,
-0.030597452,
0.01076674,
0.014263966,
0.008330471,
-0.019293685,
-0.023445822,
-0.036203492,
0.015613084,
0.0051508765,
0.008094703,
-0.002401887,
-0.0052425642,
-0.010210066,
-0.00003865511,
0.012253389,
-0.001204218,
0.01482719,
0.010210066,
-0.042674016,
-0.0040473514,
0.037513316,
-0.0332171,
-0.00988261,
-0.006555661,
-0.009915356,
-0.03450072,
0.030571256,
-0.002843952,
0.013379836,
0.01673953,
0.007046845,
-0.046813052,
0.022005016,
-0.011251375,
0.007944073,
-0.005082111,
-0.0011444574,
-0.005782866,
-0.011323415,
-0.02110124,
0.004987149,
-0.010085633,
0.01533802,
-0.017499227,
0.009044324,
-0.009640293,
0.03408158,
-0.02544985,
0.031278558,
0.005304781,
0.011303768,
-0.01998789,
-0.025096199,
-0.007348104,
0.0129213985,
0.01224684,
-0.012011072,
0.005288408,
-0.0026180076,
-0.0016209052,
0.0070402957,
-0.0076755593,
-0.0074463403,
-0.01076674,
-0.003821407,
0.032850347,
0.01880905,
0.003344959,
0.01799696,
-0.0199224,
-0.0028930702,
-0.0063100695,
-0.007714854,
0.007636265,
0.021769248,
-0.011303768,
-0.0054979795,
0.014447342,
-0.009849865,
0.019332979,
-0.0015914342,
-0.06297626,
-0.00023801929,
-0.031723898,
-0.021258418,
0.036308277,
0.0075052823,
0.019529453,
-0.032300223,
-0.028056396,
-0.008749614,
0.0010838781,
-0.009620646,
0.016844317,
0.014342556,
-0.0075576752,
0.0037231701,
-0.00951586,
0.020996453,
-0.011690165,
0.0061627147,
0.03693699,
-0.02863272,
0.013622154,
-0.028056396,
0.030414077,
0.007989917,
-0.018455397,
0.025607029,
0.020249855,
-0.0056486093,
0.0162287,
-0.013065479,
-0.0057271984,
0.022948088,
-0.022031214,
0.017499227,
-0.03667503,
-0.012155152,
0.00013845232,
0.022633731,
-0.006771782,
0.0053604483,
-0.010635758,
0.00053211534,
0.0034055384,
0.010190419,
0.007020648,
-0.0029290905,
-0.001666749,
-0.00044861418,
-0.01807555,
-0.011487143,
0.011978326,
0.01799696,
0.0011780215,
-0.011303768,
0.012135505,
0.0110614505,
0.014552128,
0.0051607005,
-0.02831836,
-0.010046338,
-0.029968737,
0.016765727,
-0.0082846265,
-0.009253896,
0.0162287,
0.018232727,
0.0001164514,
0.023668492,
0.0028455893,
-0.004653144,
0.008310824,
0.004417376,
0.004345336,
-0.032562185,
-0.015036762,
0.018756658,
0.006824175,
0.00981057,
0.008657927,
-0.0035234224,
-0.0088609485,
-0.008350118,
-0.00171423,
-0.003991684,
-0.011775304,
0.01571787,
0.008369765,
0.048882574,
0.0324574,
0.02094406,
-0.0009168757,
0.021926427,
-0.02205741,
0.0040800967,
0.019909302,
-0.021769248,
0.0011649233,
0.00031517603,
-0.0021841289,
-0.024244813,
0.016058423,
0.008310824,
-0.03651785,
0.014866484,
0.020734489,
-0.006447601,
-0.016372781,
0.014119886,
0.01091737,
-0.031095184,
-0.03450072,
0.011107294,
0.021481087,
-0.014984368,
-0.019896202,
-0.011519888,
0.011965228,
-0.004440298,
0.030466469,
-0.009011579,
0.012410567,
0.016490664,
-0.0077345013,
0.007112336,
0.006234755,
0.029759165,
0.002254532,
0.023956653,
-0.015036762,
-0.010229713,
-0.0035299715,
0.00048545294,
-0.0028832466,
0.036413062,
0.011519888,
-0.013543564,
-0.0054979795,
-0.023799473,
-0.012895202,
0.0004989605,
-0.025109297,
-0.007989917,
-0.009044324,
0.022096705,
-0.0023020129,
0.002077706,
0.0026196449,
0.03997578,
-0.020734489,
-0.00590075,
-0.033767223,
0.0051901713,
0.0019630964,
0.015835753,
0.008808556,
-0.016909808,
0.013491171,
-0.0014473537,
0.0025590656,
-0.013340541,
-0.01931988,
0.010498227,
-0.0013212834,
-0.021350106,
-0.0028374027,
0.037460923,
0.010570267,
0.013275051,
0.027558664,
-0.018887639,
-0.007426693,
-0.003696974,
0.007105787,
0.0022954638,
0.020708293,
0.03570576,
0.018416103,
0.031068988,
-0.0019188898,
-0.015023664,
0.007904778,
0.009050873,
-0.016909808,
-0.0063035204,
0.020747587,
-0.0060022613,
0.020328443,
0.006581858,
-0.021114338,
-0.013333992,
0.01600603,
-0.006889666,
-0.018861443,
0.0060743014,
0.015220136,
-0.00054644153,
0.009594449,
-0.013988904,
-0.01852089,
0.016150111,
0.01356976,
-0.0009938278,
-0.025882091,
0.014814092,
-0.01364835,
0.0020989904,
-0.016569253,
0.0081667425,
0.009666489,
-0.012855907,
-0.02146799,
0.0034775785,
-0.019490158,
-0.005789415,
-0.011264473,
-0.0017387893,
0.0018010058,
-0.021520382,
-0.022895696,
0.0064083063,
0.003696974,
-0.019044818,
-0.02057731,
-0.0014743689,
-0.010144575,
-0.007642814,
0.024310304,
0.020393936,
0.010092182,
0.020459427,
-0.00531133,
0.0032041532,
0.03916369,
-0.023812572,
-0.005930221,
0.010747093,
-0.020996453,
0.018193433,
-0.008736515,
0.0028226674,
-0.024284108,
-0.009470016,
0.024100732,
0.0027539018,
-0.029418612,
0.0050428165,
0.002485388,
0.01231888,
0.006483621,
0.040080566,
0.028213575,
-0.030597452,
-0.022673026,
-0.03649165,
-0.0039622127,
-0.013052381,
0.0032483595,
0.0057206494,
-0.0104851285,
0.022620633,
0.002685136,
-0.007963721,
-0.01667404,
0.001301636,
-0.018167237,
-0.0021186378,
-0.0034350094,
0.031907275,
0.020027185,
-0.009686137,
0.0058974754,
0.028056396,
-0.014224672,
0.002279091,
-0.025148591,
0.012155152,
0.013478072,
-0.023432724,
0.007217122,
-0.012371273,
-0.009528958,
-0.019961694,
-0.006129969,
-0.018913835,
0.0027866473,
0.015246333,
-0.007590421,
-0.03738233,
0.002308562,
-0.018900737,
0.0154952,
0.003286017,
-0.006811077,
-0.026589395,
0.01807555,
-0.023118366,
-0.007400497,
0.0162287,
-0.03570576,
-0.015979834,
0.029759165,
-0.024349598,
0.0036773265,
0.0013523917,
0.0060513797,
-0.017892174,
-0.010838781,
-0.024677055,
-0.031854883,
0.0039491146,
-0.01984381,
0.018389907,
0.032195434,
0.02994254,
-0.007688658,
0.04508409,
0.007105787,
-0.0094438195,
0.017237263,
-0.01379243,
0.03672742,
0.0008661201,
0.01150679,
0.015914343,
-0.009011579,
0.012070014,
-0.020551113,
0.005612589,
-0.011290669,
-0.019791417,
-0.008206038,
0.011035254,
-0.03819442,
-0.019057916,
0.02309217,
-0.0071516302,
0.006758684,
-0.0361511,
0.007570774,
0.021965722,
-0.0052916827,
-0.00884785,
0.005111582,
0.025921386,
-0.011906286,
0.017590916,
-0.0054095667,
0.00020230617,
0.007059943,
-0.026667984,
0.0030633472,
0.005622413,
0.008160193,
0.012004523,
-0.010183869,
0.011860442,
-0.0006160259,
0.012404018,
-0.006503268,
-0.0126921795,
-0.016922906,
-0.028868487,
-0.02183474,
-0.019411568,
-0.036753617,
-0.011094196,
-0.029182844,
0.007662461,
-0.0010208428,
-0.014447342,
0.023472019,
-0.019739024,
-0.004698988,
0.016582351,
-0.015482101,
0.030702237,
-0.041416585,
-0.0024280832,
0.01711938,
-0.010308303,
-0.014408046,
-0.025318868,
-0.003379342,
-0.00056977273,
0.034291152,
0.012102759,
-0.017643308,
-0.0045057894,
-0.0025181337,
0.020524917,
0.0019270763,
-0.01629419,
0.0034906769,
0.010098731,
0.008075056,
-0.017944567,
-0.0353914,
-0.01791837,
0.0287637,
-0.025999974,
0.012960693,
-0.017459933,
-0.015979834,
-0.023733983,
0.012351626,
-0.012351626,
0.004735008,
0.008081605,
0.01216825,
-0.016307289,
-0.024873529,
-0.022620633,
-0.012233742,
0.018337514,
0.019215096,
-0.012207545,
0.022987384,
0.023720885,
0.0145390285,
-0.0135042695,
0.004957678,
-0.0033531454,
0.048253857,
-0.0009193316,
-0.013216108,
0.006689918,
0.0052392897,
0.009614097,
-0.015901245,
-0.0044271997,
-0.01415918,
-0.011637772,
-0.026720377,
0.03947805,
0.01423777,
-0.017289655,
0.0068045277,
-0.01379243,
-0.014211574,
-0.014054394,
-0.0029356396,
-0.004911834,
-0.03379342,
-0.0006283054,
0.015822655,
-0.017604014,
0.023642294,
0.015482101,
0.018730462,
-0.003608561,
0.022358669,
-0.029549593,
0.00825843,
0.013635252,
0.0132685015,
-0.015809556,
0.008061957,
-0.01659545,
-0.029732969,
0.00789168,
-0.017328952,
-0.0287637,
-0.031514328,
0.012934497,
-0.010092182,
0.00044615826,
-0.008736515,
0.020538015,
0.006018634,
0.024297206,
0.011257924,
0.00082068564,
0.037460923,
-0.025659421,
-0.017224165,
0.031592917,
-0.0027931964,
-0.004780852,
0.02529267,
0.005000247,
0.013301247,
-0.012102759,
-0.027087128,
-0.018285122,
0.0065196413,
-0.011474044,
-0.0139627075,
-0.026222644,
0.0037886614,
-0.011552634,
0.014263966,
0.0076755593,
-0.013412582,
0.0023593176,
0.00010867433,
-0.0067455857,
0.01504986,
-0.03748712,
0.0067521348,
0.020158168,
-0.014263966,
-0.027270503,
-0.009869512,
-0.008356667,
0.026681082,
0.006843822,
-0.012043817,
-0.0059433193,
0.016398977,
-0.040761676,
0.002884884,
-0.016477566,
0.009614097,
-0.012810064,
0.01003324,
-0.012449862,
-0.003621659,
-0.017001495,
0.01446044,
-0.022555143,
-0.023603,
0.011238276,
-0.02493902,
0.010347597,
0.008382863,
-0.022738518,
-0.018101746,
0.033138506,
-0.009987396,
-0.008291176,
0.019188898,
-0.022594437,
0.011126942,
-0.0206559,
0.02441509,
-0.017080085,
-0.00037370872,
-0.004600751,
-0.0026114585,
0.006234755,
0.01858638,
-0.015927441,
0.01931988,
-0.008893695,
0.007197474,
-0.0046236734,
-0.015704772,
-0.0014989281,
-0.0368846,
-0.015547592,
-0.026288137,
0.009037775,
0.012593943,
-0.015010565,
0.008710319,
-0.00707959,
-0.0054488615,
-0.016438272,
-0.0064606993,
0.022555143,
-0.00825843,
-0.0051148566,
-0.017525423,
-0.020341542,
0.019673534,
0.0031010045,
-0.028606521,
0.009162208,
-0.022397963,
0.0020449602,
-0.022306276,
0.009843316,
0.010675053,
-0.017983861,
-0.001086334,
0.0022741791,
-0.027008539,
-0.01711938,
0.0045549073,
0.012620139,
-0.0035954625,
-0.01681812,
-0.007321907,
-0.029759165,
-0.002814481,
-0.010092182,
-0.024978314,
-0.006270775,
-0.000112255875,
0.19636858,
-0.016647844,
-0.010864977,
-0.0013482985,
0.010878075,
-0.01216825,
-0.002703146,
-0.009653391,
-0.020891668,
0.0063755605,
0.027637253,
0.007610068,
-0.013910314,
0.00449924,
-0.005118131,
-0.025685618,
-0.040447317,
-0.0015938901,
-0.016438272,
-0.023144562,
0.018376809,
0.017132478,
0.030125916,
0.0016454645,
0.047022626,
-0.007276064,
-0.014630716,
-0.017132478,
0.019450864,
0.006329717,
-0.03583674,
0.03953044,
-0.0016045325,
0.01681812,
-0.007145081,
-0.0012410567,
-0.009306288,
0.0031763194,
0.018180335,
0.004905285,
-0.023131464,
0.0020334993,
-0.010747093,
0.009869512,
-0.012724925,
0.037513316,
0.00855969,
-0.0024117106,
-0.01165742,
-0.011316866,
-0.019739024,
-0.0021988645,
0.0016724796,
0.035941526,
0.010426187,
-0.014499734,
0.032719363,
0.010720897,
-0.00044984213,
0.027087128,
-0.015744066,
0.006012085,
-0.022122901,
0.040918853,
0.0065982305,
0.021821642,
-0.029340023,
-0.0020334993,
0.011532987,
-0.0022397963,
0.0029962189,
-0.006208558,
-0.012973791,
-0.00020455742,
-0.0153511185,
0.000504691,
0.010884624,
0.021900231,
0.007164729,
0.011860442,
0.006948608,
0.0067030163,
-0.02153348,
-0.004345336,
-0.017551621,
-0.041128423,
-0.002573801,
0.021520382,
-0.03738233,
-0.01452593,
-0.0054848813,
-0.024677055,
-0.019228194,
-0.008343569,
0.046446305,
0.0017993685,
0.006850371,
-0.008638279,
-0.0075642243,
-0.008173292,
-0.0074463403,
0.06308105,
-0.025999974,
0.0191758,
0.009496213,
0.026667984,
0.004145588,
-0.00015543908,
-0.014879582,
0.006224931,
0.0040244292,
-0.02774204,
-0.0058680046,
-0.024519876,
-0.012718376,
0.025345065,
-0.012128956,
-0.0042241774,
0.016097717,
-0.005340801,
0.013556662,
-0.0129083,
-0.0075052823,
0.037303742,
-0.0014096964,
-0.008520395,
-0.01689671,
0.011153138,
0.0022152371,
-0.049982823,
-0.0055569215,
-0.00061397924,
0.01460452,
0.023524411,
0.0043780813,
-0.003952389,
0.009063971,
-0.040080566,
-0.019961694,
0.014447342,
0.0016127189,
-0.021598972,
0.025253376,
-0.001895968,
0.0045319856,
0.004987149,
0.0058319843,
0.012934497,
-0.014945074,
-0.007367751,
0.012790416,
-0.032038257,
-0.00766901,
-0.01821963,
0.028554128,
-0.015246333,
0.0004633497,
0.008369765,
0.013582858,
0.0094438195,
-0.008952636,
0.0287637,
-0.005923672,
0.007197474,
-0.00685692,
-0.01747303,
-0.16367541,
0.02368159,
0.013726939,
-0.00013169856,
0.0028750603,
0.0154952,
-0.00825843,
0.008160193,
0.000700755,
0.014447342,
0.052576274,
-0.012770768,
-0.011087647,
-0.005701002,
0.015521396,
-0.0059924377,
-0.007479086,
0.024454385,
0.024794938,
0.0004082962,
0.041364193,
-0.019581845,
0.006090674,
-0.008153644,
0.0006066115,
0.009063971,
0.014473538,
-0.0019942047,
-0.01371384,
-0.040028173,
-0.0101380255,
-0.0005427577,
0.047048822,
0.006896215,
0.010589914,
0.0045483583,
-0.0126921795,
-0.032693166,
-0.0081667425,
0.021415597,
0.044219606,
0.01062266,
0.00937178,
0.014617618,
-0.044350587,
0.009470016,
0.0060022613,
0.017551621,
0.02516169,
-0.011218629,
0.026052369,
-0.00055258133,
0.019725926,
0.03148813,
0.008179841,
0.022319375,
0.012587394,
0.027191913,
-0.0057042767,
-0.010884624,
0.007262965,
-0.025462948,
0.028423147,
0.0063166185,
0.019870006,
0.0018091922,
0.018258926,
0.032562185,
-0.006529465,
0.014041296,
-0.024952117,
0.010563718,
0.011886639,
-0.006025183,
0.010465481,
0.021874035,
-0.0032254378,
0.01629419,
0.014277064,
-0.010229713,
-0.024349598,
-0.007125434,
-0.028737504,
0.0057632187,
-0.017171772,
0.022515848,
-0.007721403,
0.0047153607,
-0.0031910548,
-0.006928961,
0.017014593,
-0.021887133,
-0.026877556,
-0.018232727,
-0.00811435,
0.02368159,
0.0026900477,
-0.0057501206,
0.002048235,
0.017525423,
0.023930456,
-0.019372273,
-0.02315766,
-0.01423777,
0.005848357,
-0.0026016347,
-0.015586887,
0.003415362,
0.04026394,
-0.0162287,
-0.004381356,
0.02382567,
0.012187898,
0.02228008,
0.010478579,
0.007760698,
-0.019267488,
-0.016254896,
0.030047327,
-0.035155635,
0.046603482,
0.0083959615,
0.016477566,
0.022096705,
-0.009653391,
-0.0063035204,
-0.12490467,
-0.035731956,
0.022083607,
-0.010583365,
-0.032483596,
0.007767247,
-0.019634238,
0.011696714,
-0.01791837,
0.025934484,
-0.013556662,
-0.0006066115,
0.004751381,
-0.015324922,
0.016241798,
0.0032401732,
0.015744066,
-0.014866484,
-0.024768742,
0.031278558,
-0.010537522,
-0.01387102,
0.0017617112,
-0.0015840665,
0.002161207,
0.000065439956,
-0.018507792,
0.023341035,
0.01062266,
0.009476565,
0.014630716,
-0.003385891,
0.00759697,
-0.0086317295,
-0.005006796,
-0.010426187,
0.00140151,
-0.01711938,
0.04642011,
-0.012600492,
-0.0026049095,
0.015796458,
-0.0017240538,
-0.006536014,
0.006513092,
0.00073800306,
-0.018717362,
0.0049183834,
0.020184364,
-0.025620127,
-0.03444833,
-0.0435123,
-0.027558664,
-0.00088167423,
0.010511325,
0.0074987332,
-0.0106947,
0.031068988,
-0.015665477,
-0.01143475,
0.020826176,
-0.01594054,
-0.0025099472,
0.011271022,
0.033505257,
-0.011015607,
0.00033441404,
-0.02758486,
0.023039777,
-0.027611056,
-0.01584885,
-0.00431259,
-0.029287629,
-0.013451876,
0.0015906156,
0.0039720363,
-0.018547086,
-0.0032336242,
0.021441793,
-0.01763021,
-0.023105267,
-0.0014792808,
0.02072139,
-0.017551621,
0.02787302,
0.009804021,
-0.000877581,
-0.017459933,
0.0067521348,
-0.02713952,
-0.021061944,
0.041285604,
0.0041914317,
0.00981057,
-0.002018764,
0.0054030176,
-0.0022758164,
-0.008729966,
0.034841277,
0.028554128,
-0.00013681504,
-0.029313825,
-0.057003472,
0.00943727,
-0.00685692,
0.027270503,
0.013884118,
-0.026589395,
0.026222644,
-0.01673953,
0.014735502,
0.015324922,
-0.0032663697,
0.017014593,
-0.0040146057,
0.009280092,
0.0036020116,
0.009993945,
0.020747587,
-0.00878236,
0.009424172,
0.030623648,
-0.0028046572,
-0.009109815,
0.00567808,
0.019280586,
-0.01594054,
-0.0053506247,
0.0007249049,
0.026366726,
-0.0011984875,
0.014211574,
0.020014087,
-0.038482584,
-0.0016127189,
0.0153511185,
-0.017905273,
-0.018756658,
0.0025295946,
0.025345065,
0.0000030139347,
0.012462961,
-0.0004870902,
-0.04979945,
0.017748093,
-0.004220903,
0.001507933,
-0.015167744,
-0.041023638,
0.037277546,
0.026877556,
0.00034157714,
0.036858402,
-0.010642307,
0.006129969,
-0.040080566,
-0.013766234,
0.010812584,
0.024650859,
-0.011054901,
0.0071516302,
-0.019647336,
0.02242416,
0.040447317,
0.020420132,
0.007046845,
0.00016485344,
-0.01651686,
-0.011939031,
0.010871526,
0.0002390426,
-0.004698988,
-0.0011460946,
-0.011670518,
-0.0054161157,
0.003785387,
0.018691165,
0.016189406,
-0.0048004994,
0.016726432,
-0.012443313,
0.017604014,
0.011192433,
-0.003002768,
-0.032562185,
0.0026654887,
0.0126921795,
0.0074987332,
-0.015691673,
0.009299739,
-0.0051083076,
-0.011192433,
-0.002927453,
0.010458932,
0.008638279,
0.011474044,
0.04120701,
0.021075044,
0.015023664,
-0.0059924377,
0.020171266,
0.048856378,
-0.0054095667,
0.0044533964,
0.0041652354,
-0.03156672,
-0.0057795914,
0.008225685,
-0.037722886,
-0.029994933,
-0.029104255,
0.00040747758,
0.017813586,
0.0049544033,
0.010851879,
-0.006797978,
-0.032640774,
0.004122666,
-0.021926427,
0.018455397,
-0.016569253,
0.014591422,
-0.028554128,
-0.015102252,
-0.0118800895,
-0.008120899,
-0.0048266957,
0.0029471004,
0.022555143,
-0.0331909,
0.022895696,
0.006084125,
0.020524917,
0.009155659,
-0.038168225,
-0.0002990079,
0.004921658,
0.0002889796,
-0.003015866,
0.017132478,
-0.016713334,
0.07937524,
0.027663449,
-0.008756163,
0.006896215,
0.0014997467,
0.015010565,
-0.003281105,
0.017839782,
0.016425174,
-0.023733983,
0.003863976,
-0.013163716,
0.019293685,
-0.025489144,
-0.016529959,
0.006968255,
-0.022397963,
-0.048280057,
0.015298726,
-0.019123407,
0.0045057894,
0.0074463403,
-0.011277571,
-0.002320023,
-0.053440753,
-0.009463467,
0.024952117,
0.0023216603,
-0.0062511275,
-0.022266982,
-0.0017125928,
-0.005959692,
-0.044298194,
-0.020014087,
0.0037067975,
-0.026602494,
-0.019267488,
-0.019293685,
-0.0024231714,
0.0140151,
-0.01055062,
0.017106282,
-0.019791417,
-0.0125742955,
0.009594449,
-0.028423147,
-0.0051901713,
-0.007649363,
-0.01998789
] |
Progressive kidney failure is a genetically and clinically heterogeneous group of disorders. Podocyte foot processes and the interposed glomerular slit diaphragm are essential components of the permeability barrier in the kidney. Mutations in genes encoding structural proteins of the podocyte lead to the development of proteinuria, resulting in progressive kidney failure and focal segmental glomerulosclerosis. Here, we show that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm. We identified five families with autosomal dominant focal segmental glomerulosclerosis in | [
-0.004992182,
0.012010761,
0.0027108085,
-0.02756436,
-0.004737205,
0.04374869,
-0.021887764,
0.006602563,
-0.033254374,
-0.0005527298,
0.024799872,
0.020411583,
0.012607943,
0.010017914,
-0.012701882,
-0.019458773,
0.020277385,
-0.016667446,
-0.0011012659,
0.0024323466,
-0.024383856,
0.01114518,
-0.01113847,
-0.020022407,
-0.014412913,
0.0075486624,
0.008857097,
-0.040125333,
-0.02577952,
-0.022478238,
-0.0077432496,
0.0015181198,
-0.010487608,
-0.012104699,
0.014855767,
-0.0050022467,
-0.0054551666,
0.014157935,
0.0055960747,
-0.010105142,
0.025470864,
0.009279822,
-0.023739703,
0.0015072162,
-0.006538819,
0.014855767,
0.008883936,
0.010507737,
-0.023753123,
0.0006823152,
0.014896027,
0.002821522,
0.010373539,
-0.029067382,
0.012010761,
-0.021954864,
0.021257032,
0.014869187,
0.0007427045,
-0.022639276,
0.0049452125,
0.004129957,
-0.01713714,
0.010125272,
-0.020733658,
0.027752237,
-0.0007397689,
0.01549992,
0.0043480294,
-0.0073071048,
0.06538148,
0.01967349,
-0.022075644,
-0.0154194,
0.02663839,
-0.031026678,
0.008937616,
-0.0075218226,
-0.03250286,
0.023296848,
0.014882606,
-0.026061337,
-0.011433707,
0.029765213,
0.00555917,
-0.008025067,
-0.00235686,
0.01281595,
-0.01205773,
0.0008525794,
-0.008273333,
0.03014097,
-0.00472714,
-0.002283051,
-0.0034086404,
-0.004116537,
0.008353853,
0.018183889,
0.0003973532,
-0.015741477,
-0.016492989,
0.015151003,
-0.01380902,
-0.020559201,
-0.021391232,
0.0042339605,
0.003083209,
0.002049881,
0.0112592485,
-0.010440638,
-0.010091723,
0.018559644,
0.014694729,
-0.020049246,
0.0151912635,
-0.005082766,
0.04229935,
-0.0153925605,
-0.011601455,
-0.02743016,
0.017070042,
-0.0077767996,
0.014949706,
-0.0055088457,
0.025323246,
0.0046701054,
-0.024679093,
0.0016380597,
0.0033834781,
-0.0022964708,
0.00012402871,
0.014466591,
0.011903401,
-0.008320303,
-0.017486056,
-0.006381136,
-0.024410697,
-0.013319195,
-0.03099984,
-0.031482954,
-0.007139357,
0.023551825,
-0.022048803,
-0.012373096,
0.023256589,
0.03875651,
0.006777021,
0.010641936,
0.0044084187,
0.00064163626,
0.0096689975,
0.011574616,
-0.01026618,
-0.04482228,
0.0038582052,
0.009877005,
-0.001517281,
0.02404836,
-0.01376876,
-0.007119227,
-0.014480012,
0.010038043,
-0.0028366195,
0.005418262,
0.009232853,
0.023645764,
-0.0018301312,
0.008689349,
0.0073205247,
0.006733407,
-0.00020937053,
-0.002418927,
-0.016009873,
0.016627187,
0.01971375,
0.0035864532,
-0.02403494,
-0.009964234,
-0.036663014,
-0.029845733,
-0.027779076,
0.019083017,
0.013453393,
0.011004272,
0.007058838,
-0.0022964708,
0.050995406,
-0.002876879,
-0.019592972,
-0.027282542,
0.010178952,
0.015083904,
0.011648424,
-0.020210285,
-0.63255775,
-0.03344225,
0.021874346,
-0.015244942,
-0.0065891435,
0.046969455,
0.004908308,
-0.003693812,
-0.015540179,
0.010950592,
-0.013419844,
0.03360329,
-0.0017814842,
0.004629846,
-0.013822439,
-0.022599017,
-0.0059684757,
-0.007045418,
0.027014146,
-0.0030865641,
-0.005243804,
-0.006122804,
0.0001629253,
0.022853995,
0.0038816899,
0.01885488,
0.009514669,
-0.012259027,
-0.010131982,
0.006441525,
-0.045010157,
0.015768316,
-0.03094616,
-0.008769868,
0.05163956,
-0.014963126,
0.008219655,
0.016130652,
0.020183446,
0.043319255,
-0.010172241,
0.011353188,
0.04066213,
-0.0020616236,
-0.011252539,
0.021163093,
0.014842347,
0.001246368,
0.008286754,
0.0024709287,
0.0058342773,
0.01115189,
-0.032824937,
0.025618482,
0.011883272,
-0.0011700427,
0.023712864,
-0.015701218,
0.0057134987,
-0.014989966,
-0.007796929,
0.011286088,
-0.0043312544,
-0.008977875,
0.014466591,
-0.035589427,
-0.035321027,
-0.0058611166,
0.01033328,
0.01643931,
-0.008494761,
0.038407594,
0.0036770373,
0.0025531254,
0.01207786,
0.030624084,
-0.00948112,
0.011822882,
-0.002534673,
0.02316265,
-0.008964456,
0.007796929,
0.0021907894,
0.015634118,
0.015996454,
0.010460768,
-0.013943218,
0.027993795,
0.014010317,
0.0037508463,
0.008481341,
-0.012420066,
-0.0052840635,
-0.039078586,
-0.023337109,
0.0173116,
-0.017539736,
0.017512897,
0.0026068047,
-0.017673934,
-0.008233074,
-0.024558315,
-0.013231966,
-0.028289031,
0.029228419,
0.022988193,
-0.038300235,
0.0038481401,
0.035830982,
-0.03889071,
0.004401709,
-0.02572584,
-0.010105142,
-0.03344225,
-0.008004936,
-0.01882804,
0.018707262,
0.006196613,
0.009675708,
-0.009387181,
0.0073607843,
0.008226364,
0.018264407,
-0.02234404,
-0.008353853,
-0.0076627308,
-0.0038984646,
-0.0074278833,
-0.005233739,
0.0026923562,
-0.009977654,
-0.029469976,
0.03014097,
-0.016627187,
0.010232631,
-0.0075889216,
0.013681531,
0.026101597,
0.0015290234,
-0.032476023,
-0.0037407815,
-0.019311156,
0.0071729063,
0.020331064,
0.0018183888,
-0.004401709,
-0.015768316,
-0.0028131348,
0.014896027,
-0.022733215,
0.009695837,
-0.012708592,
0.003864915,
0.027255703,
0.01117873,
-0.01380902,
-0.0007078968,
-0.028960023,
-0.03003361,
-0.00857528,
0.014453172,
0.003302959,
-0.016855324,
0.016707705,
-0.020035828,
-0.03180503,
0.008072036,
0.009118784,
-0.004804304,
-0.017848393,
-0.0058879564,
-0.010131982,
-0.033093333,
0.017284758,
-0.016895583,
0.0096018985,
0.0124804545,
-0.010802974,
-0.008447791,
-0.00029439782,
-0.007924418,
-0.0464595,
-0.009863585,
-0.014869187,
0.028584268,
0.015660958,
0.04031321,
0.044070765,
0.011755783,
0.055450793,
-0.010547997,
0.018250987,
-0.029979931,
0.011567906,
-0.019324575,
-0.01205102,
0.03014097,
0.007864028,
-0.014265294,
0.033898525,
0.012379806,
-0.035347868,
0.002925526,
-0.041789394,
0.032717578,
-0.031053519,
-0.0034304475,
-0.013211836,
0.008025067,
0.008716188,
0.0034220603,
0.032314982,
-0.0036334228,
-0.023833642,
-0.019123277,
0.027805917,
-0.003945434,
-0.007219876,
-0.008447791,
-0.02995309,
-0.018331507,
0.010440638,
0.01803627,
0.016841903,
-0.0325297,
0.009769646,
0.0081458455,
0.035857823,
0.034784235,
-0.02761804,
-0.010776134,
0.021283872,
0.02836955,
0.013466814,
-0.022424558,
0.0012388193,
0.021149674,
0.004381579,
0.036528815,
-0.00026336443,
0.0060724793,
-0.0059013763,
0.00016439309,
0.0034656746,
-0.0021035606,
-0.020263964,
0.0153254615,
-0.0009486152,
-0.014761828,
0.009232853,
-0.0017378698,
0.015218103,
-0.008273333,
-0.015956195,
0.010588257,
-0.0133259045,
0.006112739,
0.0033818006,
0.03430112,
0.010621807,
0.0021320777,
-0.0028500394,
0.010943882,
-0.024410697,
0.010252761,
0.016063552,
0.0058678268,
0.005059281,
0.0004183217,
0.012621363,
-0.038863868,
-0.014882606,
0.011910112,
-0.018599903,
-0.01702978,
0.023417627,
-0.0010316505,
0.02157911,
0.01882804,
0.0055088457,
-0.015956195,
-0.02136439,
0.014681309,
0.013138027,
-0.022746636,
-0.021270452,
-0.028503748,
0.0037139417,
-0.021283872,
0.020760499,
-0.005317613,
0.009937394,
0.00773654,
0.008789998,
0.0047606896,
-0.014909446,
0.0030395945,
-0.00689109,
0.0070923874,
0.005475296,
-0.0065019145,
0.00073893013,
-0.013359454,
-0.009749517,
0.0326639,
0.014211615,
-0.019364834,
-0.0039991136,
-0.019606391,
-0.010460768,
0.010058173,
-0.024504635,
-0.008904066,
-0.008917486,
-0.0088235475,
-0.019915048,
0.002538028,
0.013996897,
0.030785121,
0.0030731442,
-0.021901185,
-0.02159253,
-0.009870295,
-0.024732772,
0.021619368,
0.04286298,
0.014077416,
0.028611107,
-0.0018737457,
0.01113847,
-0.004190346,
-0.025967399,
0.036099378,
0.0008706124,
-0.0026504193,
-0.000079732745,
0.0065992083,
0.0016716092,
0.004968697,
0.039185945,
0.008420952,
-0.023860482,
0.0015567018,
0.024343597,
0.0015046999,
-0.019472193,
0.039910614,
0.0172445,
-0.014815507,
-0.010849943,
0.008494761,
0.0067703114,
0.018774362,
0.00344219,
-0.022505078,
0.0045090676,
-0.010930463,
-0.015285202,
-0.0012354644,
-0.01462763,
0.016144073,
-0.009206013,
0.014493431,
0.018680422,
0.009581769,
0.0045996513,
0.01702978,
0.0042373156,
0.009991074,
-0.013332615,
-0.0062435823,
-0.009494539,
-0.0061395788,
-0.008984585,
0.009179173,
-0.01027289,
-0.007213166,
-0.0124469055,
0.009783066,
0.0025631902,
0.01200405,
-0.008930906,
0.0087564485,
-0.02577952,
-0.028745305,
-0.029979931,
-0.01800943,
-0.015057065,
-0.011661844,
0.0011457192,
-0.0056195594,
0.0039018197,
-0.024638833,
-0.003438835,
0.014828928,
-0.023310268,
-0.030597243,
-0.0063173915,
0.007139357,
0.00002445452,
0.015365721,
-0.0038883998,
0.014198195,
-0.00472714,
0.0014568918,
-0.025578223,
0.005851052,
-0.021941444,
-0.0015634118,
0.004542617,
-0.012614653,
-0.0033264437,
-0.01638563,
0.0055491053,
0.0062234527,
-0.03864915,
0.0015994776,
0.01208457,
0.00557259,
-0.0040259534,
0.033683807,
0.026866527,
-0.018465705,
-0.0074614333,
0.011071371,
-0.022773474,
-0.02140465,
-0.028691625,
-0.0073540746,
-0.013513783,
0.0019945244,
-0.0032694095,
0.007045418,
-0.03419376,
0.0042238957,
-0.0075151124,
0.015083904,
-0.020076087,
0.019512452,
0.024357017,
-0.017231079,
-0.0015374109,
-0.012701882,
-0.019485613,
0.002663839,
-0.0041366667,
0.05936939,
0.004197056,
-0.013507073,
0.018653583,
0.02312239,
-0.033039656,
-0.025309825,
-0.027993795,
-0.009729386,
0.047747806,
0.018559644,
-0.03341541,
-0.007038708,
0.008454502,
-0.015553599,
0.020022407,
-0.012567684,
0.00474056,
-0.021914605,
0.0066830823,
0.010722456,
-0.0008697736,
0.0153254615,
-0.03524051,
-0.001853616,
-0.0122791575,
0.012171798,
0.004019243,
-0.0023686024,
0.008018357,
-0.0123462565,
-0.0025430603,
-0.0172445,
-0.036501974,
-0.0016539957,
-0.020357903,
0.018546224,
0.045224875,
0.0090248445,
0.0083471425,
0.020331064,
0.043560814,
0.0068239905,
0.017996011,
0.00859541,
0.014855767,
-0.021203354,
0.01637221,
0.013023959,
-0.00032039877,
0.025497703,
-0.02584662,
0.02490723,
0.0111250505,
-0.013359454,
-0.0061160936,
0.0037877508,
-0.034784235,
-0.018613324,
0.01808995,
0.008165975,
-0.00045711343,
-0.035696786,
-0.009252982,
-0.009843456,
-0.02061288,
-0.007857319,
-0.015754897,
0.035428386,
-0.0028114573,
0.023659185,
-0.009299952,
0.020196864,
0.00851489,
-0.025376925,
-0.0056967237,
-0.0067401165,
0.008186105,
-0.019431934,
0.021740148,
-0.009199303,
0.009259692,
-0.01196379,
0.0007397689,
-0.026463931,
-0.027671717,
0.010984142,
-0.016184332,
-0.0037609113,
-0.006381136,
-0.030355686,
-0.047882,
0.0058644717,
0.0110579515,
-0.017915491,
0.023806803,
-0.0032358598,
-0.02663839,
0.01634537,
0.0007355752,
0.02312239,
-0.010366829,
0.02917474,
0.02663839,
-0.019405095,
-0.030463045,
-0.012742141,
0.0189354,
-0.0008924196,
0.049546063,
0.025189048,
-0.019445354,
-0.0117356535,
0.00602551,
0.0003956757,
-0.0139029585,
-0.034086403,
0.029067382,
0.018371766,
0.0024306693,
0.0017747744,
-0.0070789675,
-0.003232505,
0.010058173,
-0.01966007,
-0.010802974,
-0.0189354,
-0.009246272,
-0.028611107,
0.0057906625,
-0.02054578,
-0.0060590594,
-0.00007160745,
-0.026490772,
-0.0069917385,
-0.019445354,
0.013399714,
0.012332836,
-0.007313815,
0.015593858,
-0.005700079,
0.0011809462,
0.009219432,
0.007159487,
0.011366608,
-0.027148344,
-0.021740148,
0.050056018,
0.0075151124,
-0.029228419,
0.029121062,
0.0065421737,
-0.0013361132,
-0.028745305,
-0.007240006,
-0.018653583,
-0.018425446,
-0.00428764,
0.03341541,
-0.0041400217,
-0.013540623,
0.008696059,
-0.010903623,
-0.013688241,
-0.027094664,
-0.015432821,
0.030248327,
-0.04726469,
-0.029013703,
-0.0034170276,
0.009380471,
0.013849279,
-0.010802974,
0.0033297988,
0.011822882,
0.02826219,
-0.016130652,
0.01878778,
-0.0069246395,
-0.0052001895,
-0.029845733,
0.00860212,
-0.03255654,
-0.040930524,
0.0154194,
-0.016238011,
-0.029738374,
-0.010574837,
-0.030248327,
0.009689127,
-0.0072064563,
-0.0056229145,
-0.00047934006,
-0.001052619,
0.023296848,
-0.013849279,
0.00851489,
0.029094221,
-0.01114518,
0.020841017,
0.0037575562,
-0.0058611166,
0.0024843486,
0.019123277,
-0.01637221,
0.011856432,
-0.015338882,
0.0019995568,
-0.003529419,
-0.005995315,
-0.00095113146,
-0.014117676,
0.0045191324,
-0.011695394,
-0.020237124,
0.012238897,
0.014506851,
-0.007817059,
-0.036716692,
0.00071460666,
-0.00053008384,
0.00944757,
-0.01713714,
-0.0033784457,
-0.0057168533,
-0.014815507,
-0.034837913,
0.002663839,
-0.014305553,
0.058671556,
0.007964677,
-0.0023904096,
0.0006126997,
0.012681752,
-0.03091932,
-0.012936729,
-0.004210476,
0.00514651,
0.008306883,
0.007944548,
0.0018586484,
-0.0009964234,
-0.013701661,
0.017888652,
-0.013332615,
-0.019686911,
0.02836955,
-0.011742364,
0.035535745,
-0.009514669,
-0.03354961,
-0.017432377,
0.05008286,
0.006085899,
0.021699887,
0.026786009,
-0.00090332323,
0.028154831,
-0.0017127076,
0.010561417,
-0.0068307007,
-0.0041702166,
0.009930684,
-0.03540155,
-0.00075402745,
0.013285645,
0.003386833,
-0.003125146,
0.022760056,
0.015835416,
0.008105585,
-0.005824212,
-0.0020867856,
-0.012728722,
0.0026772588,
0.010742585,
0.028933182,
0.014963126,
-0.0047003003,
0.017445797,
0.027175184,
-0.007186326,
-0.028020633,
-0.0044788728,
-0.0048479186,
-0.0064582997,
-0.0032341823,
0.013996897,
-0.005830922,
-0.0073339446,
0.006085899,
-0.03540155,
-0.023565246,
-0.01890856,
-0.017593415,
-0.011782623,
0.019136697,
0.0074211736,
0.001885488,
-0.0005200189,
-0.0075218226,
-0.022437979,
-0.0049485676,
-0.009320081,
0.02411546,
-0.025336664,
0.003051337,
-0.007998227,
-0.022250101,
0.014117676,
-0.005337743,
-0.026745748,
-0.022585597,
0.029926252,
0.19045442,
-0.011742364,
0.010943882,
-0.005307548,
0.0056094946,
-0.0110244015,
0.00687767,
-0.0110915005,
-0.013138027,
0.013835859,
0.007991517,
0.0007997388,
-0.022263521,
0.0019928468,
0.0076157614,
-0.02152543,
-0.035965182,
-0.0020029116,
-0.011849722,
-0.018573064,
-0.007481563,
-0.016466148,
0.014144516,
0.013131317,
0.0291479,
0.014144516,
0.008327013,
0.007226586,
0.04184307,
0.022719795,
-0.014426332,
-0.0019190377,
0.007038708,
-0.0013218547,
0.011071371,
0.008327013,
-0.020760499,
-0.009977654,
0.0066294027,
0.0034723845,
-0.0075956318,
0.012654913,
-0.007240006,
-0.010024623,
-0.016801644,
0.01023934,
-0.0006856701,
-0.020102926,
-0.000942744,
-0.004985472,
-0.031590313,
0.014453172,
0.017633675,
0.027940115,
-0.032314982,
-0.013822439,
-0.020290803,
0.015889095,
-0.0045325523,
0.01286963,
-0.007541952,
0.024773031,
-0.03765608,
0.04731837,
0.0081458455,
0.034864753,
-0.018492544,
-0.011843012,
-0.0020448486,
-0.03593834,
-0.0022746634,
-0.018573064,
-0.021941444,
0.007454723,
-0.0007213166,
-0.018170469,
0.019982148,
0.013460103,
0.023444466,
0.019472193,
-0.00022939546,
-0.0017965815,
-0.022021964,
0.00558601,
-0.008259914,
-0.037199806,
0.03513315,
0.0027980374,
-0.016560087,
0.005944991,
-0.010125272,
-0.0018989079,
-0.010574837,
-0.012104699,
-0.010427219,
-0.010393669,
-0.0007066387,
0.0051867696,
-0.0017529671,
-0.024611993,
-0.015526759,
0.07719094,
0.014922867,
0.02392758,
-0.016412469,
0.00016900616,
-0.010789555,
0.011084791,
0.008749738,
-0.021189934,
0.0034052853,
0.0011943661,
0.010937173,
-0.005344453,
0.0067669563,
0.009487829,
0.010085013,
-0.012520715,
0.010125272,
-0.006703212,
-0.0019576198,
-0.0047606896,
0.0090583945,
-0.0016128975,
-0.032207627,
-0.014144516,
0.006760246,
0.015312042,
-0.00474056,
-0.041869912,
0.008508181,
-0.038004998,
-0.013507073,
-0.0008353853,
-0.0035629685,
-0.0003717716,
0.0048344987,
0.006176483,
0.001607865,
0.017942332,
-0.010735875,
-0.0015751541,
0.0057638227,
0.031160878,
0.0058812466,
0.003452255,
0.024142299,
0.0090583945,
-0.021310711,
-0.014278714,
-0.009340211,
-0.020331064,
-0.019458773,
0.00041916044,
0.015862256,
-0.0326639,
-0.01803627,
-0.006461655,
0.0069380593,
0.00258332,
-0.019915048,
0.028879505,
0.012534134,
-0.019512452,
-0.007058838,
-0.009192593,
-0.1691974,
0.013835859,
0.007796929,
0.008266624,
0.02058604,
0.0054417467,
0.00015202166,
0.014708149,
-0.00040364373,
0.003620003,
0.03687773,
-0.011621585,
0.0015894128,
-0.020854438,
0.009132204,
0.013446683,
-0.024276497,
0.03803184,
0.008387403,
0.0026487417,
0.027108084,
-0.022599017,
0.0032375373,
-0.01465447,
-0.008333723,
0.016412469,
0.0025262856,
-0.022156162,
-0.01800943,
-0.0054820064,
-0.012071149,
0.0096018985,
0.030409366,
0.0019626522,
0.00045250036,
-0.020210285,
-0.012218768,
-0.0050425064,
-0.003606583,
0.023914162,
0.027993795,
0.041655194,
0.029550496,
-0.0032694095,
-0.026410252,
0.025269566,
-0.0032408922,
-0.00023925066,
0.023471307,
0.017284758,
0.02318949,
0.012976989,
-0.0011910112,
0.024893811,
0.023672605,
-0.0066461777,
-0.01882804,
0.015043645,
0.0011281056,
0.013030669,
-0.014305553,
-0.007441303,
0.026074756,
-0.0056967237,
0.01115189,
-0.0137352105,
0.007474853,
-0.004666751,
-0.026235795,
0.01375534,
-0.0086558,
-0.013097768,
0.007401044,
-0.004119892,
0.025953978,
0.02404836,
-0.01966007,
0.018747522,
-0.0019978792,
-0.016855324,
-0.012856211,
0.00009315259,
-0.016560087,
-0.029711533,
-0.010735875,
-0.00010531432,
-0.0056296242,
0.009367051,
-0.015821995,
-0.016989522,
-0.006605918,
-0.017633675,
0.025162207,
-0.0047170753,
0.006609273,
0.035857823,
-0.009548219,
-0.009152333,
-0.010910333,
-0.006807216,
0.022183001,
0.0009964234,
-0.018801201,
0.013822439,
0.025403764,
0.012829371,
0.023592085,
0.010152112,
0.03881019,
-0.0016741256,
-0.0018234212,
-0.01709688,
0.001759677,
0.01725792,
-0.00774996,
-0.009165754,
0.033066496,
-0.004381579,
0.008857097,
-0.029872572,
0.07654679,
-0.008776578,
0.0038481401,
0.015030225,
0.0068340553,
-0.01896224,
-0.12550238,
-0.02227694,
0.011628294,
0.03349593,
0.013399714,
-0.0017160625,
-0.0022746634,
0.017687354,
-0.015915934,
0.018626744,
-0.02223668,
-0.013627851,
-0.01032657,
-0.01465447,
0.0029423009,
-0.009367051,
0.016788224,
-0.006102674,
-0.026947046,
0.029335778,
-0.022719795,
0.0009645513,
0.0059651206,
-0.008984585,
-0.021780407,
-0.009843456,
-0.020384742,
0.02305529,
-0.004613071,
0.012386516,
0.012111409,
-0.00048059816,
0.021136254,
-0.0073540746,
-0.00772983,
-0.016895583,
0.0077700894,
-0.016224591,
0.058242124,
-0.009977654,
-0.0057369834,
0.0066629522,
0.01888172,
0.00008266833,
-0.0034556098,
-0.0066461777,
-0.03006045,
0.010487608,
0.03011413,
-0.025242725,
-0.022075644,
-0.035428386,
-0.031187717,
-0.020854438,
0.00013577107,
-0.020921536,
-0.027886435,
0.019311156,
-0.0146142095,
0.008159265,
-0.009266403,
0.009910555,
0.011051241,
0.015714638,
0.002286406,
-0.014063996,
-0.022867413,
-0.03701193,
0.017056622,
-0.029228419,
0.0061731283,
-0.004542617,
-0.01207786,
0.018734101,
-0.015875675,
0.0038414302,
-0.0077633797,
-0.010386959,
-0.009353631,
-0.03518683,
-0.008749738,
-0.0032761195,
0.027644878,
-0.034462158,
0.023873903,
0.029067382,
0.026987307,
-0.004015888,
0.013413134,
-0.010085013,
-0.010051463,
0.010534577,
0.000055723805,
0.0005502136,
-0.007850609,
0.014063996,
0.0066294027,
-0.015607279,
0.009407311,
0.014480012,
-0.015996454,
-0.011648424,
-0.046003226,
0.02159253,
-0.019364834,
0.004898243,
0.013050798,
-0.011373318,
-0.005515556,
0.0036300677,
0.0025615126,
0.016291691,
-0.034596357,
0.007850609,
0.008186105,
-0.012171798,
-0.038944386,
-0.013500363,
0.037468202,
0.011473967,
0.015620698,
0.033469092,
-0.017539736,
0.021189934,
-0.0049720523,
0.045895867,
-0.0040662126,
-0.0075084027,
-0.029416298,
0.017915491,
-0.004039373,
0.0025044784,
-0.0052672885,
-0.019203797,
-0.011507516,
-0.0006835733,
0.019861368,
-0.008488052,
0.009293241,
0.01207786,
0.024410697,
0.019311156,
-0.0052840635,
-0.032717578,
0.030328847,
-0.010199081,
-0.020559201,
-0.013668111,
-0.041762553,
-0.009112074,
0.0021270453,
-0.010709035,
0.029469976,
-0.00036464233,
-0.014842347,
0.011782623,
-0.03164399,
0.011286088,
-0.008749738,
0.00031809224,
0.0016128975,
-0.021015475,
0.02047868,
0.0069246395,
0.007850609,
-0.0027426805,
0.021122834,
-0.006377781,
-0.025269566,
0.0049586324,
0.018532805,
-0.010776134,
-0.016909003,
0.027779076,
0.024705932,
0.046137422,
0.00343548,
0.0004772432,
-0.015567019,
-0.02324317,
0.0014644405,
0.028637948,
0.037360843,
0.033737488,
-0.013822439,
0.025376925,
0.031053519,
-0.01633195,
0.017378697,
0.020196864,
-0.0014183098,
0.018344926,
-0.02235746,
0.028745305,
-0.00939389,
0.04066213,
0.026450513,
0.019190377,
0.0004097246,
0.0014459882,
0.007910998,
0.020008987,
-0.009367051,
-0.017700775,
-0.0077700894,
0.0039018197,
-0.0038078807,
0.010668776,
-0.024450956,
-0.029013703,
-0.01199063,
0.007313815,
-0.0027644879,
0.015567019,
0.0057638227,
-0.0020112991,
0.0057906625,
0.014734988,
0.010286311,
-0.00685754,
0.0003424157,
0.017472636,
0.023082132,
0.014989966,
-0.019176956,
0.0025749325,
-0.0067669563,
0.017123722,
0.03601886,
-0.016815064,
0.01123241,
0.001843551,
0.009132204,
-0.01971375,
-0.023390789,
-0.0034757396,
0.004227251,
-0.022169583,
0.0012061085,
0.025095107,
-0.0151912635,
0.08363247,
0.013849279,
-0.0062570022,
-0.0019223926,
0.00042608005,
0.021283872,
-0.0064281053,
0.020988636,
-0.006676372,
-0.035804145,
0.015365721,
-0.007656021,
0.007642601,
-0.006293907,
0.008984585,
0.018586483,
0.017660514,
-0.0116685545,
0.006525399,
-0.0068374104,
0.025712421,
-0.023390789,
0.0055122008,
0.022706376,
-0.018707262,
-0.02327001,
0.03803184,
0.00041601516,
0.0076895705,
-0.028289031,
-0.00022478239,
-0.007031998,
-0.03440848,
-0.020210285,
0.012373096,
-0.021954864,
-0.0020163315,
-0.014131095,
-0.013211836,
-0.00471372,
0.008642379,
0.02497433,
-0.021324132,
-0.02140465,
0.0038883998,
0.0064750747,
-0.021807246,
0.0012908212,
-0.014453172
] |
Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator. A previous study suggested that fibrinogen is an important factor associated with atherosclerosis progression. The present study was performed to examine the levels of plasma HMGB1 protein in atherosclerosis patients. We studied 24 patients with peripheral artery disease (PAD) with atherosclerosis, and 10 healthy controls. We found that the concentrations of HMGB1 were increased in the plasma of the patients | [
-0.026690096,
-0.008665867,
-0.008568789,
-0.032592464,
-0.014264056,
0.005704975,
-0.032126486,
0.021875005,
-0.028217463,
-0.025123896,
-0.00044534728,
-0.012710801,
0.0062680305,
0.0026372971,
-0.019338023,
-0.00963018,
0.037278116,
0.014393494,
-0.008115756,
-0.006018862,
-0.02076184,
0.019105034,
-0.0008190992,
-0.012950262,
-0.017034028,
0.0147818085,
0.015869087,
-0.04362057,
-0.023635361,
-0.025175672,
0.028295126,
0.007792162,
-0.02059357,
0.024502594,
0.003507767,
-0.0066854674,
-0.0036728005,
0.014484101,
0.003999631,
-0.0006532569,
0.02230215,
-0.0054460997,
0.011254625,
0.007578589,
-0.01379808,
-0.020049931,
0.0144452695,
-0.017991869,
-0.024230774,
0.032463025,
0.01621857,
-0.0026890724,
0.019325078,
-0.020282919,
-0.008970046,
0.013137947,
0.011312872,
0.020541795,
-0.009280697,
-0.02288462,
-0.015053628,
-0.0069313995,
-0.013196194,
-0.009753146,
-0.010575077,
0.00541374,
-0.017124634,
0.024049561,
0.009293641,
0.008148116,
0.015726704,
0.032566577,
-0.017396454,
-0.0034851155,
0.009500742,
-0.002216624,
-0.026250007,
-0.013487429,
-0.023881292,
0.0061741876,
0.01417345,
-0.015441941,
0.01482064,
0.021059547,
0.014044012,
-0.0068084337,
-0.0062000756,
0.010329144,
0.02353181,
-0.008646452,
0.009041238,
0.0067954897,
0.010717458,
-0.00085833506,
-0.0008672339,
-0.005061022,
-0.0053975605,
0.021642016,
0.004339406,
0.0005391897,
-0.00491864,
-0.012251297,
-0.015972637,
-0.014341719,
-0.032074712,
-0.005423448,
-0.008529957,
-0.005051314,
-0.00481509,
-0.012438982,
-0.019907549,
0.0354401,
-0.002648623,
-0.04041051,
0.019130921,
-0.024127224,
0.021603186,
-0.0029382403,
0.008957103,
-0.021020714,
0.003507767,
0.02305289,
0.023376485,
-0.007863352,
0.0012644465,
0.0048215617,
-0.023169383,
-0.0026372971,
-0.019972268,
-0.004879809,
0.0074556232,
-0.001975546,
-0.004009339,
-0.016270343,
-0.031194534,
-0.00007513465,
-0.030728558,
-0.012393679,
-0.018470788,
-0.026457107,
-0.011416423,
0.02984838,
-0.012484285,
-0.006038278,
-0.008374632,
0.015454886,
0.040980037,
0.018897934,
0.019338023,
-0.0028751392,
-0.020580625,
-0.0054525714,
0.019273303,
-0.013137947,
-0.009177147,
0.0034559919,
-0.027130185,
0.02271635,
-0.027363172,
-0.010257954,
0.0044494276,
0.009487798,
0.017021084,
0.007902184,
0.01598558,
0.01632212,
-0.02619823,
-0.0053198976,
0.009093013,
-0.011364647,
-0.032281812,
0.02845045,
-0.016555108,
0.008296969,
0.023130553,
0.0039090244,
-0.0045303265,
0.020399412,
-0.02653477,
-0.042429745,
-0.024813246,
0.01652922,
0.051956374,
-0.027518498,
-0.006510726,
0.015416054,
0.058454156,
-0.015933806,
0.016542163,
-0.0327219,
0.0007333466,
0.02482619,
0.0005739762,
-0.04385356,
-0.6494676,
-0.009125372,
0.02780326,
-0.01147467,
0.017034028,
0.01598558,
0.023078777,
-0.008458767,
-0.022832846,
0.01792715,
-0.016296232,
0.056434926,
0.005798818,
-0.009190091,
-0.016801039,
-0.03383507,
-0.012374263,
-0.019596899,
-0.002022467,
0.011073412,
0.004701832,
-0.014639426,
0.010795121,
-0.0013437272,
0.017034028,
0.023104666,
0.0097725615,
-0.02984838,
-0.010355032,
0.043180484,
-0.008141644,
0.0162574,
0.0039154966,
0.022496307,
0.044319537,
-0.019868718,
-0.00016058389,
0.03880548,
0.025123896,
0.01957101,
-0.0010719076,
-0.013823967,
0.004125833,
0.001545165,
-0.00092143606,
0.03722634,
0.0061418284,
0.016477445,
0.0096431235,
0.00092952594,
-0.022962283,
0.0030482626,
-0.011830624,
-0.0141863935,
0.0019399505,
-0.0004971224,
0.028062137,
-0.013448598,
-0.011668826,
0.0019383326,
0.008614092,
0.013668642,
-0.015001853,
-0.017538836,
-0.013448598,
0.0007515488,
-0.02080067,
0.0018218384,
0.008478182,
-0.002153523,
0.0118500395,
0.028295126,
0.017344678,
0.013357991,
0.03142752,
0.03603551,
0.009811393,
0.033627965,
-0.013953405,
0.012853184,
0.012523117,
0.023389429,
-0.0028168922,
0.002341208,
0.01594675,
0.028528113,
-0.030081367,
0.019583954,
-0.0050772014,
-0.019066203,
0.0057146833,
-0.011468198,
-0.021499636,
-0.023777742,
-0.024334325,
0.035155334,
0.011675298,
0.0182378,
0.009546045,
-0.009882583,
-0.020049931,
-0.0027877688,
-0.000013588451,
0.020049931,
0.010309729,
-0.0014270529,
-0.054571018,
-0.004682416,
0.014251113,
-0.029356515,
0.006400704,
0.005096617,
-0.0004026732,
-0.029434178,
-0.013526261,
-0.021253703,
0.025732255,
-0.004993067,
-0.0014230079,
-0.032488912,
0.007598005,
-0.0045885737,
0.0146523705,
0.0060220985,
0.03613906,
0.027130185,
-0.00051330216,
-0.019040314,
-0.00871117,
-0.025822861,
0.0013849855,
0.0054687513,
0.030107256,
-0.011429367,
0.04142013,
-0.0057082116,
0.017098747,
0.02311761,
0.011138131,
-0.04320637,
-0.0023460619,
-0.014717089,
0.011261097,
-0.019143865,
-0.008232251,
-0.01759061,
0.0098243365,
0.011947118,
0.023829518,
0.010445639,
0.0095654605,
-0.0093842475,
-0.00031247118,
0.020334695,
0.0052648867,
-0.0011730309,
0.0071902755,
-0.0010856604,
0.008258138,
0.009151259,
-0.011248154,
-0.007837465,
-0.006711355,
0.01390163,
0.004012575,
-0.01748706,
0.00022975227,
0.014458213,
-0.022004442,
-0.0044688433,
0.006588389,
-0.014264056,
-0.023143496,
0.019985212,
0.020619458,
0.02694897,
-0.0016220186,
0.0037536991,
-0.009584877,
-0.0042229113,
-0.0039122603,
-0.022496307,
0.007759802,
-0.0074426793,
0.047659036,
0.0072485222,
0.009403664,
0.01096339,
0.009811393,
0.01984283,
-0.008646452,
0.014393494,
-0.03274779,
-0.0028816112,
-0.012917902,
-0.026767757,
0.002292669,
-0.005837649,
0.0034851155,
0.016723376,
0.022133881,
-0.041704893,
-0.00061159406,
-0.008484654,
0.019687505,
-0.020917164,
0.0036566206,
-0.00874353,
0.016542163,
-0.0019480404,
0.008044565,
0.005704975,
0.0030676783,
-0.01786243,
-0.0030531164,
-0.015183066,
0.010943974,
-0.004743899,
0.009714315,
-0.013979293,
-0.0074556232,
0.0103420885,
0.023700079,
-0.002768353,
-0.009241866,
0.0030272289,
0.0283469,
0.032799564,
0.005666144,
-0.012781993,
-0.009927887,
0.009028293,
0.018173082,
-0.011358175,
0.009209506,
-0.0151442345,
0.011746489,
0.00029669594,
0.0228199,
0.011649411,
0.009571932,
-0.0064880745,
0.019312134,
-0.010549189,
0.003326554,
-0.018561395,
0.012536061,
0.018289575,
0.00031024645,
0.029926043,
-0.0015265582,
0.002651859,
0.0025127132,
-0.02309172,
-0.005125741,
-0.008652924,
0.010665683,
0.0021794105,
0.025421603,
0.0021438152,
0.038572494,
0.016024413,
-0.024036618,
-0.015480773,
0.0034236324,
0.009164203,
-0.00618066,
-0.0050869095,
-0.016839871,
0.0061450643,
-0.028269237,
0.008555845,
0.004701832,
-0.056849126,
0.009157731,
0.014600595,
0.03391273,
0.021577299,
0.02305289,
0.027932698,
-0.013099115,
-0.03678625,
0.009345416,
0.02130548,
-0.010905143,
-0.020774784,
-0.016296232,
-0.010050853,
-0.011319344,
0.022030331,
0.0055625937,
0.010490942,
0.011765905,
-0.015221897,
-0.003889609,
0.01144231,
0.025072122,
-0.00392844,
0.022107994,
-0.013668642,
-0.01270433,
-0.0057664583,
0.0029301504,
-0.0023217923,
0.040565837,
0.020425301,
0.012963206,
0.021577299,
0.011176962,
-0.00122966,
0.020269975,
-0.0158432,
0.0128078805,
0.0052745943,
0.0069896467,
0.03487057,
-0.00084053737,
-0.0016349625,
0.04514794,
0.0013146037,
-0.005164572,
-0.028217463,
-0.005491403,
-0.01940274,
0.019609842,
0.009203034,
-0.0008445823,
0.004067586,
0.0031016557,
0.005442864,
-0.018807327,
-0.040798824,
0.029460065,
0.011908287,
0.031997047,
-0.0008364924,
0.0029269145,
0.0013445362,
-0.009241866,
0.018949708,
0.010063796,
-0.020011099,
0.002761881,
-0.017732993,
-0.01519601,
0.0042487993,
0.010600964,
0.027181959,
0.033731516,
-0.0010120426,
-0.0061224126,
0.0148335835,
-0.002645387,
-0.020399412,
-0.015920863,
0.020930108,
0.00090444734,
-0.0018768496,
-0.0076821395,
-0.024916796,
-0.01321561,
-0.0029689819,
0.0019933437,
0.00689904,
0.0051516285,
0.017668273,
0.017034028,
0.024088394,
0.006578681,
-0.005847357,
0.0071902755,
-0.008529957,
0.019713392,
-0.011299929,
0.017991869,
-0.009584877,
0.007209691,
-0.030987434,
0.004255271,
-0.03370563,
0.0180307,
-0.014341719,
-0.00071959384,
-0.0002956847,
-0.021085434,
-0.010950446,
0.0147818085,
-0.018600225,
0.00026919038,
-0.021693792,
-0.03650149,
-0.03134986,
0.003517475,
0.019441573,
0.02309172,
-0.02257397,
-0.026923083,
-0.006083581,
0.025382772,
0.0072614662,
0.007863352,
-0.010458582,
-0.0078762965,
0.015597267,
-0.0099019995,
-0.015377223,
0.008174003,
-0.017046971,
-0.019506292,
-0.0043620574,
-0.0009675483,
-0.02096894,
0.012380735,
0.007267938,
0.0020435008,
0.0008110093,
0.006834321,
-0.002786151,
-0.008186948,
-0.018380182,
0.016555108,
-0.006769602,
-0.0055787736,
0.004549742,
-0.012995565,
-0.031065095,
-0.003692216,
-0.02486502,
-0.009371304,
0.006086817,
0.009313057,
-0.022276262,
0.0038054741,
-0.0074362075,
-0.004378237,
0.005999447,
-0.019816943,
0.0014666932,
0.015519604,
0.0041355407,
0.011513501,
0.010387392,
0.0028314542,
-0.008174003,
0.0070284777,
0.009940831,
0.028476339,
-0.008620564,
-0.0050933813,
0.016839871,
0.017940093,
-0.014380551,
-0.028424563,
-0.01400518,
-0.012659026,
0.020748895,
-0.005556122,
-0.025835805,
-0.037019238,
-0.009054181,
0.00408053,
-0.0053198976,
0.00041501026,
-0.00017605576,
-0.017409397,
-0.002656713,
-0.0063780523,
-0.008885912,
0.02920119,
-0.026819533,
-0.008044565,
0.0076821395,
-0.027622048,
-0.0005056168,
0.002892937,
-0.011487613,
-0.019816943,
-0.017137578,
-0.022936396,
-0.026560657,
-0.009546045,
-0.0005052123,
0.025266279,
0.038132407,
0.053742617,
0.0021082198,
0.012277185,
0.01621857,
0.010115572,
0.009021821,
-0.021473747,
-0.0022910507,
-0.012076556,
0.016904589,
0.012076556,
-0.0076562515,
0.011772377,
-0.030573232,
0.010219122,
0.012484285,
-0.011778849,
-0.0009772561,
0.005798818,
-0.03828773,
0.0008195037,
-0.010639795,
-0.031039208,
0.013966349,
-0.0566938,
-0.017409397,
0.005290774,
-0.0071579157,
0.021020714,
-0.013629811,
0.017681217,
-0.012076556,
0.029019978,
-0.0017182882,
-0.0036113174,
0.0036792723,
-0.0076109483,
-0.0022473654,
0.016658658,
0.029278852,
0.0074232635,
-0.0015047155,
-0.006691939,
0.000023271014,
-0.009759618,
-0.004944528,
-0.040358737,
-0.006937871,
-0.008542902,
-0.011002221,
-0.012743161,
-0.018897934,
-0.0067372425,
-0.031039208,
0.008762945,
0.0035789579,
-0.014484101,
0.0004983359,
-0.0121089155,
-0.006886096,
0.034792908,
0.00066984113,
0.021849118,
-0.030728558,
0.031220421,
0.008245194,
-0.009319529,
-0.026508883,
0.0049542356,
0.012348375,
-0.0066207484,
0.035414208,
-0.006264794,
-0.016736321,
-0.018095419,
-0.009843753,
0.0098502245,
-0.00751387,
-0.03443048,
0.039219685,
0.0007551892,
-0.0019674562,
0.012458398,
0.0024835898,
-0.03142752,
-0.0029447123,
0.00019061753,
0.009759618,
0.010102628,
-0.005931492,
-0.0009999077,
0.010743346,
-0.008303441,
0.019959325,
-0.0030434085,
-0.041860215,
-0.01786243,
-0.018742608,
0.017059915,
0.0048215617,
0.02130548,
0.025382772,
0.003692216,
-0.011992421,
-0.0006819759,
0.012542533,
0.007714499,
0.008225778,
-0.005624077,
0.037614655,
-0.010497414,
-0.011629995,
0.041316576,
0.007837465,
-0.008225778,
-0.009073596,
-0.009759618,
-0.028579889,
-0.021421973,
0.006151536,
0.007966903,
0.021797342,
-0.0124713415,
0.017344678,
-0.015325448,
-0.007882768,
-0.034197494,
0.0027327577,
0.0061903675,
-0.04781436,
-0.032877225,
-0.0039381483,
0.0059541436,
0.012529588,
0.0003571677,
0.0036760364,
-0.018975597,
0.028631663,
-0.030806221,
0.026211174,
0.0055625937,
0.009144788,
-0.010646267,
-0.00751387,
-0.019855773,
-0.029330628,
0.011028109,
0.0073714885,
-0.022897564,
-0.0054622795,
-0.012510173,
0.021214873,
0.015001853,
-0.019765167,
0.035465986,
-0.011448782,
-0.0006403131,
0.014587651,
0.008970046,
0.020502964,
-0.020826558,
0.0018800854,
0.009843753,
-0.010329144,
-0.008238723,
0.025551042,
-0.010575077,
0.0143676065,
0.0019464224,
-0.017849486,
-0.012827296,
0.029304741,
-0.02113721,
-0.0043296977,
-0.016542163,
-0.008885912,
-0.009889056,
0.005478459,
0.001661659,
-0.0052843024,
-0.007449151,
0.0146782575,
-0.011875927,
0.010413279,
-0.032488912,
0.020347638,
0.011183434,
-0.012322488,
-0.024942683,
0.01652922,
-0.023298822,
0.016736321,
-0.00033734753,
-0.028295126,
-0.0148335835,
0.009293641,
-0.06347635,
-0.020192312,
-0.016063243,
0.017745936,
0.0019011191,
0.017344678,
-0.010439167,
0.0316864,
0.007630364,
0.008193419,
0.01571376,
-0.010283841,
0.00028476337,
-0.017901262,
0.022457475,
0.00026292074,
-0.03378329,
-0.02609468,
0.01611502,
-0.0020726244,
-0.021965612,
0.029408291,
-0.0012005365,
0.012503701,
-0.02619823,
0.01898854,
0.012814352,
0.0046435846,
0.0024852077,
-0.021745566,
-0.0032310935,
0.00033269584,
0.003511003,
-0.021434916,
-0.004145249,
0.007818049,
-0.0042779227,
0.0038993168,
-0.010096156,
-0.017953036,
0.027233735,
-0.0040190467,
0.013914574,
0.009138316,
-0.016127963,
0.017991869,
0.021849118,
0.0048571574,
-0.006365109,
0.0063359854,
-0.004122597,
-0.004187316,
0.002769971,
-0.026560657,
-0.03323965,
-0.0007143354,
0.008284026,
-0.01342271,
-0.00069815567,
-0.010730402,
-0.020166425,
-0.029356515,
0.020645345,
-0.0071773315,
0.010012021,
-0.004012575,
-0.016801039,
-0.031997047,
-0.007714499,
-0.0026227355,
-0.011882399,
0.0027020162,
-0.018664945,
0.017616497,
-0.00051492016,
-0.0069249277,
0.00751387,
-0.029149415,
-0.0069119837,
0.00751387,
0.18473376,
-0.018160136,
-0.0062356708,
-0.0035271829,
0.006219491,
-0.0019901078,
0.0097207865,
-0.014613539,
0.0011916377,
0.005410504,
0.03039202,
0.009203034,
-0.007941015,
-0.0022392757,
-0.00027161735,
-0.006536614,
-0.027673824,
0.0043976526,
0.0049218764,
-0.02694897,
0.0015241313,
-0.011591163,
0.011422895,
0.005507583,
0.02503329,
-0.008652924,
-0.008102813,
-0.0019836358,
0.030883882,
0.0070737815,
-0.015545492,
0.017901262,
0.0025531626,
0.009791977,
0.0020451187,
0.020101706,
-0.02130548,
-0.0050221905,
0.0009424697,
-0.0055690655,
-0.011164019,
-0.020399412,
-0.031531073,
-0.0018428721,
-0.0047180112,
-0.008070453,
-0.00044939222,
0.011015166,
-0.052370574,
0.017189354,
-0.022146825,
-0.010523302,
-0.012736689,
0.024062505,
-0.010296785,
-0.020710064,
0.013131475,
0.007947487,
-0.011332288,
-0.00027040386,
-0.0020693885,
0.006102997,
-0.029304741,
0.022690464,
-0.019273303,
0.03699335,
-0.028088024,
-0.008652924,
-0.0147818085,
-0.0075721173,
0.027466722,
0.008788833,
-0.010122044,
-0.00344952,
-0.008827665,
-0.009914943,
0.024463763,
0.012516645,
0.003815182,
0.009287169,
-0.011681771,
0.0034786435,
-0.03743344,
-0.0034171606,
-0.013306216,
-0.03484468,
-0.013002037,
0.01744823,
-0.031738173,
-0.00826461,
0.0064330637,
-0.005659672,
-0.01642567,
0.010607436,
0.00604475,
-0.010788649,
-0.006293918,
0.0061741876,
-0.005601425,
-0.0061483,
-0.022133881,
0.078076944,
-0.0043976526,
-0.008801777,
-0.003266689,
0.004261743,
-0.027466722,
0.014509989,
-0.010523302,
-0.0006662007,
-0.0031016557,
-0.0316864,
-0.011151075,
-0.020606514,
0.0063359854,
0.02599113,
0.013849855,
0.009093013,
0.020373525,
-0.0068602087,
0.005164572,
-0.018276632,
0.030210806,
0.029537728,
-0.010866311,
-0.00034745986,
-0.014328776,
0.013099115,
-0.027958587,
-0.038417168,
-0.014859471,
-0.009177147,
-0.005721155,
-0.012723746,
0.0017166701,
0.024541426,
-0.018289575,
-0.0010071887,
-0.011688243,
0.02165496,
-0.010355032,
-0.018108362,
0.010943974,
0.0070414217,
0.013409766,
-0.008445823,
-0.010905143,
0.010490942,
-0.023402372,
0.00874353,
-0.02801036,
-0.007999262,
-0.009086541,
-0.020477075,
0.01571376,
-0.022496307,
0.006397468,
-0.017940093,
0.008769418,
0.0036825081,
-0.027052522,
0.0314793,
0.024916796,
-0.026664207,
0.019596899,
0.005853829,
-0.16164204,
0.014471157,
0.0044073607,
-0.024166055,
0.026819533,
0.00700259,
0.009067125,
-0.00086642493,
-0.0098243365,
-0.007164388,
0.031582847,
-0.006112705,
-0.019519236,
-0.02247042,
0.010885728,
-0.00703495,
0.0057567507,
0.044190098,
0.021564353,
0.00871117,
-0.0010678627,
-0.02271635,
0.0146264825,
-0.02588758,
0.017344678,
-0.0065689734,
0.010581548,
0.018173082,
-0.010122044,
-0.0067501864,
-0.014898302,
0.010361504,
0.025939355,
0.012070084,
0.010057325,
-0.001290334,
0.010400335,
-0.015584324,
0.0023201744,
-0.0011325816,
0.030443793,
0.020399412,
-0.0013332104,
-0.0028524876,
-0.01882027,
0.013927518,
0.004698596,
-0.0029382403,
0.028994089,
0.01096339,
0.023557698,
-0.00040631366,
0.023065833,
0.03176406,
0.02811391,
0.022043275,
0.0064880745,
0.019726336,
0.007585061,
-0.007196747,
-0.004540034,
-0.006963759,
0.020127593,
0.004074058,
0.027181959,
-0.01161058,
0.00392844,
0.0011479524,
-0.013144419,
0.010122044,
-0.02801036,
-0.019765167,
0.009002406,
-0.017370567,
0.029019978,
0.014341719,
-0.025551042,
0.016697489,
-0.007643308,
0.005355493,
0.0032958125,
0.0038540135,
-0.026133511,
-0.007979847,
-0.0013315924,
0.0040837657,
-0.007973375,
0.0055011106,
-0.0110993,
-0.007902184,
0.018173082,
-0.02311761,
0.009442495,
-0.001975546,
0.02096894,
0.029615391,
-0.017914206,
-0.014121675,
-0.015765537,
0.012451926,
0.0124972295,
-0.004368529,
-0.018522564,
-0.009209506,
0.035491873,
-0.0012604016,
-0.0040967097,
-0.0075397575,
0.051619835,
-0.013979293,
-0.0143676065,
-0.01048447,
0.016645715,
0.02342826,
-0.011571748,
0.005539942,
0.03155696,
-0.018677888,
-0.003815182,
-0.037511103,
0.0723299,
0.0028977909,
0.0063165696,
0.031194534,
-0.0022732532,
-0.00805751,
-0.11960062,
0.007086725,
-0.001982018,
0.001109121,
0.0006552794,
0.0034106886,
-0.010432695,
0.020049931,
-0.00519046,
0.018975597,
-0.031168647,
0.003206824,
-0.007397376,
-0.014975965,
0.025330996,
0.011785321,
-0.0062033115,
0.004983359,
-0.009759618,
0.024606144,
-0.018664945,
-0.02476147,
0.0039252043,
-0.006481603,
0.0049121683,
0.00010708964,
-0.008193419,
0.003394509,
0.011811208,
0.008102813,
0.01652922,
0.01082748,
0.008212835,
-0.0008340655,
-0.0018881754,
-0.02640533,
0.034197494,
-0.021939725,
0.050351344,
0.0069961185,
0.009940831,
0.01632212,
0.01926036,
-0.018652001,
0.011629995,
0.0049574715,
-0.052034035,
0.012393679,
0.011662355,
-0.013170307,
-0.018444901,
-0.034741133,
-0.030340243,
-0.020619458,
0.011034581,
0.0060253344,
-0.009455439,
0.025589872,
-0.014471157,
-0.0036825081,
-0.006407176,
-0.0042876303,
-0.009086541,
0.0148335835,
0.016736321,
-0.04310282,
0.0003051903,
-0.0364756,
0.023933068,
-0.004384709,
0.006225963,
-0.00005202797,
-0.021357253,
-0.025123896,
-0.023078777,
0.011934174,
-0.025771085,
-0.0066142767,
0.0049509997,
-0.011274041,
-0.016244456,
-0.01786243,
0.010879256,
-0.002038647,
0.005704975,
0.02749261,
0.0028104205,
-0.014717089,
0.010432695,
-0.013170307,
-0.00035494298,
0.06326924,
0.012147747,
-0.016231513,
-0.0004862011,
0.029123528,
-0.0060156262,
-0.006297154,
0.0124713415,
0.00442354,
-0.021434916,
-0.008225778,
-0.049289953,
0.018677888,
0.000049171234,
0.0141863935,
-0.0012968059,
-0.008277554,
-0.0029819256,
-0.0054493356,
0.008976518,
0.022340981,
-0.0029414762,
0.015467829,
-0.0039187325,
0.007830993,
-0.0038022383,
0.002274871,
0.06663463,
0.011526445,
0.02080067,
0.015726704,
0.002472264,
0.022392757,
0.009740202,
0.03326554,
0.005818234,
0.0033492057,
-0.008510542,
0.029926043,
-0.017629443,
0.010277369,
-0.011008694,
-0.04545859,
-0.010743346,
-0.01581731,
0.0040319907,
-0.010096156,
-0.018639058,
0.012335432,
0.011642939,
0.031194534,
0.0020839502,
-0.017331734,
0.0077986335,
-0.007947487,
0.006963759,
0.0024107809,
-0.027207846,
0.0224057,
0.015532548,
-0.038831368,
0.03026258,
0.018173082,
0.00009985932,
-0.06430475,
-0.028709326,
0.018017756,
0.012561948,
0.00618066,
0.011558805,
-0.037821755,
0.0124713415,
0.014587651,
-0.011222266,
-0.0076368363,
0.010167347,
0.00076004316,
0.0012604016,
0.011144604,
0.020477075,
-0.035750747,
-0.024101337,
-0.016412726,
-0.008471711,
-0.00007285938,
-0.00066134677,
0.020839501,
-0.011921231,
0.0005759987,
-0.00009540989,
0.019350966,
0.010594492,
-0.010672155,
-0.0047212476,
0.010950446,
0.03624261,
0.008575261,
-0.008083397,
0.03582841,
-0.00052058307,
0.023570642,
-0.014406438,
0.020334695,
0.013092644,
0.0071126125,
0.02267752,
0.022910507,
0.0036889801,
0.0075462298,
0.0006597288,
0.043568797,
-0.009921415,
-0.0060220985,
-0.020917164,
-0.00983728,
-0.0121865785,
0.012892015,
-0.006691939,
-0.03303255,
-0.011552333,
-0.0073714885,
0.019803999,
0.0057017393,
-0.0081287,
-0.0005351448,
-0.008051038,
0.0024706458,
0.0013210756,
0.014328776,
-0.010432695,
0.025214503,
0.021357253,
0.0038701931,
-0.018859101,
0.007267938,
0.0019577483,
0.02271635,
0.03323965,
-0.0053231334,
0.018962651,
-0.022095049,
0.007578589,
-0.0001666513,
-0.018173082,
0.005242235,
0.008484654,
-0.026664207,
0.0048442134,
0.023570642,
-0.01909209,
0.08553256,
-0.0038281258,
-0.009669011,
0.006892568,
0.0021421972,
0.004420304,
0.016140906,
0.008122228,
-0.007986318,
-0.031867612,
-0.0064427713,
-0.024800302,
-0.013163835,
-0.04116125,
-0.018483732,
0.036941577,
-0.004624169,
0.0028185102,
0.0016511423,
-0.004915404,
0.011843568,
-0.025162729,
0.010562133,
0.003452756,
-0.024088394,
0.00094651466,
0.03383507,
-0.021525523,
-0.01072393,
-0.02076184,
-0.0063715805,
-0.0052098753,
-0.037096903,
-0.004307046,
0.021292534,
-0.03383507,
-0.021370197,
-0.027622048,
0.006099761,
0.0074362075,
-0.030340243,
0.042921606,
-0.005128977,
-0.016516276,
-0.0028589596,
-0.0120895,
-0.02759616,
0.0022473654,
-0.012542533
] |
Proteins of the Argonaute family are small RNA carriers that guide regulatory complexes to their targets. The family comprises two major subclades. Members of the Ago subclade, which are present in most eukaryotic phyla, bind different classes of small RNAs and regulate gene expression at both transcriptional and post-transcriptional levels. Piwi subclade members appear to have been lost in plants and fungi and were mostly studied in metazoa, where they bind piRNAs and have essential roles in sexual reproduction. Their presence in ciliates, unicellular organisms harbouring both germline micronucle | [
-0.016124506,
-0.014989167,
0.0003887942,
-0.0029245096,
0.013441593,
0.0312218,
-0.0007619606,
0.011056031,
-0.0065417103,
-0.03527658,
0.01763829,
-0.019679194,
0.009021884,
0.0143809505,
0.0057510287,
0.000973147,
0.007893303,
-0.013279402,
0.0094206035,
0.021084853,
-0.016976008,
0.02295005,
-0.013171274,
-0.019976545,
0.0025562004,
0.013103695,
-0.00428455,
-0.028437518,
0.021801196,
-0.040169347,
0.021328138,
-0.015773091,
-0.014245791,
-0.004244002,
-0.024707122,
-0.032627456,
0.008183896,
-0.0059064617,
0.010089642,
0.0140836,
0.045089144,
0.00050473557,
-0.0033232295,
-0.0003932291,
-0.007203991,
-0.002165928,
-0.0027673868,
0.0024936893,
-0.007379698,
0.020341476,
-0.012150821,
0.0053556873,
-0.018908788,
-0.008616406,
-0.005271213,
-0.010839776,
-0.010718133,
0.014624237,
-0.011738586,
-0.008001431,
-0.00015965693,
0.004494047,
-0.016962493,
0.00408519,
0.007427004,
0.029843176,
0.020773986,
0.002633917,
-0.010582974,
-0.015732544,
0.033303253,
0.02803204,
-0.008758323,
-0.005129296,
0.006264634,
-0.055361252,
-0.033600602,
0.011772376,
-0.025693784,
0.0031069745,
0.0075013414,
0.003922999,
0.015489257,
0.024693605,
0.0056192484,
-0.00900161,
0.016354276,
0.018773628,
-0.01880066,
-0.0020763848,
0.025950586,
0.02859971,
0.012110274,
0.010637037,
-0.02520721,
0.017030073,
0.0020713164,
0.02750492,
-0.011366898,
-0.015583868,
-0.016056925,
0.022571605,
-0.0342764,
-0.009630101,
-0.017827513,
0.007244539,
-0.011603426,
-0.008683985,
0.031302895,
0.0007269037,
-0.027085925,
0.04065592,
0.0155568365,
-0.0434402,
0.0110087255,
-0.0071499273,
0.047467947,
0.0147729125,
-0.008609648,
-0.011083064,
0.021530878,
0.021747133,
0.000037036818,
-0.031924628,
0.021706585,
0.0034245988,
-0.0019513625,
-0.00627815,
-0.008819145,
-0.0071161375,
0.01321858,
0.012258949,
-0.008582616,
0.020044126,
0.011339866,
-0.0067410707,
-0.019800838,
-0.013894376,
0.01953052,
-0.01481346,
0.011022242,
0.0281672,
-0.03281668,
0.0080487365,
-0.007994673,
0.01285365,
0.0318165,
0.0017486236,
0.015435193,
0.016516468,
0.0171382,
-0.008805629,
0.03424937,
-0.024004294,
0.015732544,
0.03135696,
-0.007751386,
0.027518434,
-0.014218759,
0.006649838,
-0.008420425,
0.021666037,
0.013732186,
0.013015841,
0.021611974,
0.019800838,
-0.0055854586,
0.006041621,
-0.0027014967,
0.012211643,
0.009690923,
0.0035513109,
-0.022463476,
0.009325992,
-0.013948441,
0.020341476,
-0.010792471,
0.031735405,
-0.02135517,
-0.0009841287,
0.015759576,
-0.009920693,
-0.0018297192,
-0.0036560593,
-0.015502772,
-0.02946473,
0.010731649,
0.015435193,
0.011569637,
0.0029633678,
-0.014070084,
0.0028282085,
0.0030647372,
0.0013769354,
-0.63492435,
-0.03689849,
0.024071872,
-0.03441156,
0.021476815,
0.024463834,
0.00064454094,
0.009853113,
0.0019919104,
0.030464908,
-0.027815785,
0.012894198,
0.0068998826,
-0.026288485,
-0.027099442,
-0.039439484,
0.0047947764,
-0.028086103,
0.038304146,
-0.0014630995,
-0.03992606,
0.01238735,
0.015597384,
0.027491404,
0.01946294,
-0.0033992566,
0.027085925,
-0.025977619,
-0.018192442,
0.022747312,
-0.010589732,
0.015637932,
-0.028086103,
0.004909662,
0.05038739,
0.005622627,
-0.007413488,
0.029248474,
0.007575679,
0.024896344,
-0.028491583,
-0.009826082,
0.017165232,
-0.0026727754,
0.00034022133,
0.0116169425,
0.004075053,
0.00833933,
0.011339866,
-0.004075053,
-0.004064916,
0.022328317,
-0.017786965,
0.00018235946,
-0.0016700622,
0.0007818121,
0.02766711,
-0.009123254,
0.011684522,
0.008555585,
-0.011765618,
0.004105464,
-0.008683985,
-0.021206494,
0.0063457293,
0.0074810674,
-0.010677585,
0.028491583,
0.0042102123,
0.0067376914,
0.025004473,
0.014272823,
-0.0027065652,
-0.0016024825,
0.004230486,
0.035952374,
-0.0067039016,
-0.00036746438,
-0.008765081,
0.022003936,
0.0052982448,
-0.005058337,
-0.013495657,
0.029005187,
0.026896702,
-0.004706923,
-0.020679373,
0.030870385,
0.00684244,
0.007163443,
0.0051732226,
0.026788576,
-0.015435193,
-0.016746238,
-0.018570889,
-0.00740673,
-0.02169307,
-0.010474847,
0.005490847,
-0.041142493,
-0.012941504,
-0.013779491,
0.005531395,
-0.013495657,
-0.0007480223,
-0.0067647235,
-0.013495657,
0.020233348,
0.029680984,
-0.020179285,
-0.0039905785,
0.0066903858,
-0.0105627,
-0.0195981,
-0.013110453,
-0.037844606,
0.0021929597,
0.026964283,
0.006781618,
-0.036817394,
0.007237781,
-0.025801912,
-0.0045278366,
-0.007913577,
-0.0012899266,
0.021841744,
-0.014340403,
-0.043764584,
-0.010434299,
-0.020868598,
0.014245791,
-0.008035221,
-0.002998847,
-0.003208344,
0.028113136,
0.030302716,
0.020976724,
0.013657848,
0.019841386,
-0.008596132,
-0.024044842,
-0.0100085465,
0.00026187114,
-0.012508994,
-0.0036391644,
-0.035952374,
-0.02859971,
-0.014462046,
0.014651269,
-0.0025730953,
0.00926517,
0.008562342,
-0.02561269,
0.02434219,
0.024693605,
0.004064916,
-0.050198168,
-0.02408539,
-0.002943094,
0.0016354276,
-0.0010018684,
0.0005541532,
-0.017246328,
-0.010177496,
-0.00733915,
-0.004700165,
0.0031711753,
0.0047407127,
-0.0021693069,
-0.033600602,
0.020436088,
-0.005288108,
-0.020706406,
0.023071693,
0.0119886305,
0.02563972,
-0.0067005227,
0.041169524,
-0.0036256483,
-0.019503487,
-0.010738407,
-0.019030431,
-0.020638825,
0.00448391,
0.0028873407,
0.020665858,
0.036547076,
0.010454573,
0.012502236,
0.03035678,
-0.01627318,
0.020773986,
-0.013691638,
0.029059252,
-0.00777166,
-0.030546004,
0.031465087,
0.022017451,
-0.008528552,
0.030464908,
0.032735582,
-0.018989883,
0.004831945,
-0.021044305,
0.0065450897,
-0.014367434,
-0.0009157043,
-0.011948083,
0.010191012,
0.014137664,
0.011028999,
-0.016881397,
-0.021801196,
-0.0156109,
0.027221084,
0.010664069,
-0.005109022,
0.017678838,
-0.019854901,
-0.007413488,
0.008927273,
0.006082169,
0.018341118,
-0.021206494,
-0.02620739,
0.0075080995,
-0.009015126,
0.004635964,
0.007244539,
-0.017516647,
-0.0041460115,
-0.005886188,
-0.0011885571,
0.016327245,
0.0038452824,
-0.0008109558,
-0.001172507,
-0.026896702,
0.025815427,
-0.01488104,
-0.031248832,
-0.00969768,
0.007886546,
-0.0014774601,
0.008102801,
-0.0075486475,
0.025518076,
0.017030073,
-0.012198128,
0.018408697,
-0.013394288,
0.021733617,
-0.02730218,
0.007413488,
-0.0058152294,
-0.02069289,
0.011245254,
0.014462046,
0.030951481,
0.008035221,
0.009042158,
-0.025369402,
-0.005065095,
-0.00016197999,
-0.0045819003,
0.0024649678,
0.024693605,
-0.0033097134,
-0.0121846115,
0.004632585,
-0.01627318,
0.006474131,
0.016259665,
-0.019544035,
0.02561269,
0.00016989947,
-0.0078324815,
0.014651269,
-0.00091654906,
0.011441235,
-0.027640078,
-0.02978911,
0.03865556,
0.011961599,
-0.013495657,
-0.03208682,
-0.042331897,
0.024288127,
-0.028302358,
0.006420067,
0.0032809922,
0.0061632646,
-0.0061260955,
0.009684164,
0.009778776,
0.0012502236,
0.015935283,
-0.028924093,
0.024490867,
-0.017165232,
0.005717239,
-0.029518792,
-0.010907356,
0.014529626,
0.050035976,
0.01830057,
0.010346445,
0.0025866113,
-0.015043231,
-0.00471706,
-0.009859871,
-0.0033924987,
0.026180359,
-0.015218938,
-0.019206138,
-0.008231202,
0.008298782,
0.0044636363,
0.012894198,
0.0069944942,
-0.02454493,
-0.033897955,
0.008292023,
-0.000488263,
0.037547257,
0.018341118,
-0.0047542285,
0.02434219,
0.013103695,
0.017165232,
-0.02322037,
0.0139889885,
0.014745881,
-0.010887083,
0.00062257756,
0.020476636,
0.016557015,
-0.013907893,
0.017043589,
0.03511439,
-0.010407266,
-0.02736976,
-0.009521973,
0.005622627,
0.009947725,
0.017354455,
0.009744986,
0.027653594,
0.0034803522,
-0.0023331875,
0.010805987,
0.031708375,
0.0026846018,
-0.0067005227,
0.031600244,
0.015029715,
-0.0006888901,
0.013360498,
-0.0051698433,
-0.029383633,
0.0035276578,
0.011779133,
-0.003473594,
-0.00074379856,
0.021544393,
0.014705333,
0.004301445,
-0.016557015,
-0.009386814,
-0.000059290585,
-0.004686649,
0.017624773,
-0.027896881,
-0.012062968,
0.01996303,
-0.015800122,
0.019273717,
-0.016151538,
0.02381507,
-0.003875693,
-0.01242114,
0.0027555604,
0.012691459,
-0.03211385,
-0.014191727,
-0.0018229611,
0.007859514,
-0.0147729125,
-0.0030309474,
-0.03422234,
-0.008454215,
-0.0027977976,
-0.036493015,
-0.01119119,
0.021625489,
-0.031708375,
-0.023423107,
-0.015827155,
0.014489078,
0.045981195,
0.002939715,
-0.015286517,
0.008954304,
0.032032754,
0.00445012,
-0.01657053,
0.0036729542,
-0.02627497,
0.009650375,
-0.010474847,
-0.004470394,
0.004091948,
-0.008474489,
-0.026977798,
-0.0049299356,
0.0077243545,
0.026180359,
0.0071296534,
-0.011995388,
0.01684085,
0.017813997,
0.044413347,
-0.02155791,
-0.009021884,
-0.0061869174,
-0.034465622,
-0.0201928,
-0.035682056,
-0.0041223587,
0.010055852,
-0.0040074736,
-0.010569458,
-0.015529805,
-0.016002862,
-0.0069269147,
-0.018354634,
-0.0053759613,
0.0072850864,
0.0048251874,
0.0038689352,
0.008413667,
0.010589732,
-0.009305718,
-0.0076838066,
-0.030924449,
-0.00042828606,
0.019611616,
0.009407088,
-0.026545288,
0.026896702,
-0.018408697,
-0.007595953,
-0.021368686,
-0.0065180575,
-0.005605732,
0.0281672,
0.0024632784,
-0.010745165,
0.005426646,
-0.009521973,
-0.0007792779,
-0.0017874818,
-0.0059470097,
-0.0024125937,
-0.017922124,
-0.0053387927,
0.008954304,
0.0049637253,
-0.016529983,
-0.032140885,
0.009231381,
0.019314265,
-0.0009503389,
0.021747133,
-0.0065890164,
-0.017665321,
-0.01677327,
-0.029870206,
-0.005291487,
-0.019800838,
-0.011312834,
-0.015124327,
0.042494085,
0.0044737733,
0.031005545,
-0.012272465,
-0.0059267357,
0.019990062,
0.028951123,
-0.0013245612,
0.016989525,
0.008629922,
-0.019881934,
0.0019631889,
0.010880324,
0.007845998,
0.016935462,
-0.035222515,
-0.0049806205,
0.0033823617,
-0.021017272,
-0.027275149,
0.005484089,
-0.039385423,
-0.03946652,
0.012536026,
-0.016800301,
0.00867047,
-0.020354992,
-0.008744807,
0.028572677,
-0.0015762955,
0.00016229677,
-0.017030073,
0.025545109,
-0.0034769732,
0.026585836,
0.0082244435,
0.023125758,
-0.025896523,
0.0029684363,
0.004308203,
0.001179265,
0.02295005,
0.0031458328,
0.022314802,
-0.0050313054,
-0.01292123,
-0.010853292,
0.0031593489,
-0.01916559,
-0.007656775,
0.012677943,
-0.023842102,
-0.0017199022,
-0.003524279,
-0.021976903,
-0.05403669,
-0.003689849,
0.0021304486,
-0.012495478,
0.014597205,
0.0003357864,
-0.04241299,
0.023598814,
0.0012071416,
0.034952197,
-0.00033071794,
0.010366719,
0.020882113,
-0.0045886585,
-0.0011370276,
-0.015286517,
0.005862535,
0.0085691,
0.0211254,
0.025126114,
0.0015365924,
-0.015448709,
-0.0046697543,
0.012732007,
-0.0059740413,
-0.04473773,
0.026910217,
-0.020111704,
0.017516647,
0.0028214506,
0.0069032614,
-0.0023889407,
0.015570352,
0.0036053746,
-0.006028105,
-0.015218938,
-0.002235197,
-0.015205422,
0.011927809,
0.014529626,
0.010359961,
0.010109916,
-0.002410904,
0.0076973224,
-0.020882113,
0.013421319,
0.00034613453,
-0.019435909,
0.028221263,
0.008731292,
0.0009782155,
0.0036425432,
0.013151,
-0.0042575183,
-0.007927094,
-0.0043994356,
0.042061575,
-0.028275328,
0.00085446023,
0.001753692,
0.021098368,
0.015827155,
0.0033857406,
-0.005119159,
-0.008400151,
-0.017557194,
-0.01690843,
0.030870385,
0.005473952,
-0.003132317,
-0.011731828,
-0.0211254,
0.01292123,
-0.008001431,
-0.035087354,
0.027518434,
-0.030113494,
-0.015732544,
0.007089106,
0.023828587,
0.0039905785,
0.02278786,
0.001258671,
-0.019003399,
0.009305718,
-0.020733438,
0.010778955,
-0.012833376,
-0.023193337,
-0.01328616,
0.0051428117,
-0.00896782,
-0.035844248,
0.033059966,
-0.03195166,
-0.019692712,
0.0013667985,
-0.0017587605,
0.03819602,
0.021909324,
-0.013921409,
0.0061767804,
0.00591322,
0.00017560151,
-0.016462404,
-0.0009951104,
0.012427898,
-0.011197949,
0.01331995,
0.0042372444,
0.015489257,
0.012982052,
0.020044126,
-0.0034448728,
0.007014768,
-0.0171382,
-0.02155791,
-0.007967642,
-0.00156109,
-0.018516826,
-0.024788218,
-0.000061560844,
-0.027194053,
-0.0014174832,
-0.011765618,
0.010569458,
-0.011549363,
-0.0045582475,
0.0031559698,
0.017192263,
-0.007940609,
-0.03311403,
-0.0057645445,
-0.0051901173,
-0.0036425432,
-0.051576793,
0.0009004989,
-0.014070084,
0.037817575,
0.007068832,
-0.038250085,
-0.0055077416,
-0.0038114926,
-0.026315518,
-0.014908072,
-0.0024818627,
0.009569279,
0.009650375,
0.016746238,
0.0010145395,
-0.005261076,
-0.013259128,
0.014475562,
0.006082169,
-0.003483731,
0.0016793543,
-0.002699807,
0.00031276708,
-0.011089821,
-0.053225737,
-0.026612869,
0.046954345,
-0.02032796,
-0.035817217,
0.018489793,
-0.034790006,
0.029140346,
-0.037249904,
-0.003012363,
-0.0049738623,
0.028491583,
0.02322037,
-0.018381666,
-0.01368488,
0.011921051,
-0.00052036333,
-0.018854724,
-0.007616227,
0.0019750153,
-0.0042372444,
0.025666753,
-0.013238854,
-0.018881755,
0.0038182505,
-0.0067985132,
0.023544751,
0.023828587,
0.0065755,
0.024936892,
0.015570352,
-0.0060956846,
-0.02613981,
-0.0102045275,
0.004335235,
0.0053320345,
0.0067478283,
0.0061294744,
-0.0010736717,
-0.014029536,
-0.011806166,
-0.0318165,
-0.0013279401,
0.02026038,
0.0012299496,
-0.026842639,
0.0030630478,
0.017705869,
0.004838703,
0.022301286,
-0.00024392031,
0.006457236,
-0.011508815,
0.006014589,
0.0050482,
-0.011339866,
0.026518255,
0.003939894,
-0.008758323,
-0.0012248813,
0.00332154,
-0.002328119,
-0.017327424,
0.010218044,
0.18057284,
-0.00484884,
-0.001215589,
0.016367791,
-0.010076126,
-0.020449603,
0.012650911,
0.0015729164,
-0.008183896,
-0.0009520284,
-0.0016920256,
0.024504382,
-0.008400151,
0.0030529108,
0.017057104,
-0.0318165,
-0.024517898,
-0.009130011,
-0.0348711,
0.008041979,
0.010751923,
-0.005223907,
0.033005904,
0.0044636363,
0.0312218,
-0.0057713026,
-0.038682595,
0.0020071156,
0.007535131,
0.012035936,
-0.013806523,
-0.0019716364,
0.004706923,
-0.00018996219,
0.034600783,
0.017381487,
-0.0065721213,
0.01757071,
0.010718133,
-0.00176045,
-0.011333108,
0.023233885,
0.024423286,
-0.008751566,
0.017516647,
0.010914114,
-0.0065146787,
0.0025832322,
-0.013367255,
-0.0022166127,
-0.045278367,
0.019679194,
0.016557015,
0.027356245,
-0.013488899,
0.0005372582,
0.008183896,
0.0149486195,
-0.018841207,
0.023761006,
-0.027869849,
-0.0028451034,
-0.016881397,
0.018341118,
-0.025910039,
0.03687146,
-0.009576037,
0.005862535,
0.04138578,
-0.013867345,
0.014908072,
-0.0051157796,
-0.009947725,
-0.000566402,
-0.006051758,
-0.02178768,
0.025058536,
0.029167378,
0.025531594,
0.012610364,
0.0033401244,
0.0018212716,
-0.03281668,
0.021030787,
-0.0018719564,
-0.03819602,
0.036709268,
-0.001849993,
-0.022044484,
-0.017057104,
0.0069742203,
-0.032438233,
-0.0059470097,
0.010880324,
0.013063147,
0.0045244577,
-0.031465087,
0.008859692,
-0.0012679632,
-0.03746616,
-0.031032577,
0.05154976,
0.01780048,
0.041629065,
-0.022463476,
0.008305539,
-0.015529805,
0.02693725,
0.0069404305,
-0.027261632,
-0.00581185,
-0.015854187,
0.015800122,
-0.008177138,
0.000025183981,
0.0035411739,
0.020949693,
-0.01212379,
0.035411738,
-0.011819681,
-0.008812387,
-0.029167378,
0.010258592,
0.025004473,
-0.018679017,
-0.0007851911,
-0.040709984,
0.009008368,
0.00235853,
-0.021247042,
0.024963925,
-0.017813997,
-0.000762383,
0.0029126832,
0.007420246,
-0.013198307,
0.018016735,
-0.01052891,
-0.0028586194,
-0.0025849217,
-0.014205243,
0.00744052,
0.0048150504,
0.011968357,
0.008021705,
0.003025879,
0.03908807,
0.022017451,
-0.0035749637,
-0.0026846018,
-0.008177138,
-0.019043947,
-0.009089463,
-0.005294866,
0.004098706,
-0.002816382,
-0.001564469,
-0.028924093,
0.006893125,
-0.001218968,
-0.014070084,
0.01597583,
0.03078929,
-0.0059537673,
-0.014070084,
-0.020746954,
-0.17159826,
0.023869134,
0.003242134,
-0.028086103,
0.032357138,
0.0006935362,
0.007203991,
0.0000055700416,
0.019638648,
0.00041139114,
0.022395898,
-0.015151358,
-0.020706406,
-0.036952555,
0.013401045,
0.019571068,
-0.00372026,
0.023355529,
0.034087177,
0.012177854,
0.022598635,
-0.012150821,
-0.0074675516,
-0.015327065,
0.004281171,
0.0063862773,
0.011522331,
-0.03378983,
-0.012867166,
-0.007359424,
-0.0050042733,
0.023598814,
0.032573394,
-0.004706923,
0.0145566575,
0.013678122,
-0.0075689214,
0.007379698,
-0.0038452824,
0.0272346,
0.032411203,
0.027018346,
0.006099064,
-0.00445012,
0.009157043,
0.017611258,
0.0040209894,
-0.0201928,
0.014597205,
-0.011684522,
-0.0073053604,
0.00017486235,
0.0217201,
0.0052475603,
0.034546718,
0.01205621,
0.016165053,
0.034952197,
0.0026001271,
-0.010278866,
0.0021760648,
-0.014989167,
0.030383812,
-0.015583868,
0.027275149,
-0.006264634,
-0.01517839,
0.013502415,
-0.018273538,
0.009630101,
-0.004115601,
-0.004159528,
0.018854724,
-0.020382024,
0.021098368,
0.010049094,
-0.012238676,
0.025680268,
-0.009549005,
0.02238238,
-0.0027454235,
0.0003604952,
-0.0060754106,
-0.02308521,
0.012130548,
-0.017192263,
-0.0045582475,
0.01331995,
-0.019260202,
-0.0026896703,
0.02126056,
-0.0061598853,
-0.0036864702,
-0.0047778813,
0.027248116,
0.029005187,
0.0024970681,
-0.016381308,
-0.009542247,
-0.0306271,
0.017030073,
-0.010914114,
-0.004858977,
0.0019919104,
0.03689849,
0.0022825028,
0.010441056,
0.021044305,
0.03587128,
-0.0052374233,
0.013975472,
0.0080487365,
0.00966389,
0.018449245,
-0.03441156,
0.026720995,
-0.007028284,
-0.024855796,
-0.0272346,
-0.044413347,
0.050765835,
0.012069726,
0.01946294,
-0.005017789,
0.0012071416,
-0.02278786,
-0.11623701,
-0.015597384,
0.011049273,
0.01281986,
-0.037195843,
-0.008021705,
-0.006862714,
0.045927133,
-0.018138379,
0.020638825,
-0.01611099,
-0.022166127,
-0.015448709,
-0.0040412634,
-0.021409234,
-0.009927451,
-0.0038047344,
-0.024382738,
-0.013644332,
0.014759396,
-0.0012637395,
-0.00833933,
-0.0034871101,
0.028707838,
0.00004852008,
-0.0014842182,
-0.0047812606,
0.009109737,
0.023936713,
0.016921945,
-0.011454752,
-0.00054274907,
0.02932957,
-0.007812208,
-0.032357138,
-0.017165232,
-0.007399972,
-0.0361416,
0.033897955,
-0.00780545,
0.0117926495,
-0.013488899,
-0.0039871996,
-0.01889527,
0.012677943,
0.006055137,
0.0065991534,
-0.004375783,
-0.0043859193,
0.002248713,
-0.03378983,
-0.04195345,
-0.035465803,
-0.017705869,
0.026315518,
-0.024639541,
0.012698217,
0.026680447,
0.0019783943,
-0.017354455,
-0.01378625,
0.003895967,
0.007616227,
0.016624594,
0.018854724,
-0.015394645,
-0.021666037,
-0.032032754,
0.03162728,
-0.01375246,
-0.004831945,
0.013069905,
0.002245334,
-0.0055685635,
-0.015191906,
0.00034085487,
-0.012975293,
-0.012671185,
-0.004477152,
-0.026410129,
-0.015016199,
-0.02759953,
0.013529447,
-0.023301465,
0.03254636,
0.0090354,
0.021868777,
-0.014299855,
0.003338435,
-0.016557015,
-0.021814711,
0.028518613,
-0.014597205,
-0.017908609,
-0.000113090326,
0.00095709687,
-0.0014968893,
-0.0013608853,
-0.003304645,
0.005484089,
-0.023166304,
-0.020773986,
-0.06493053,
0.026477708,
-0.0017080758,
-0.007210749,
0.013144243,
-0.01820596,
-0.013759217,
-0.011779133,
-0.00667687,
0.008386635,
-0.024950407,
0.004169665,
-0.020219833,
-0.014043052,
-0.012502236,
-0.029897239,
0.030302716,
-0.0171382,
0.034384526,
0.004886009,
-0.008981336,
0.024017809,
0.01524597,
0.025099084,
-0.019246686,
-0.019287232,
-0.026220907,
0.0016007931,
-0.00089205144,
0.017476099,
0.0067140386,
-0.020206317,
-0.023598814,
0.0036188904,
0.00024560982,
-0.017489614,
-0.010278866,
0.033519506,
0.012468446,
0.023342011,
0.006031484,
-0.046684023,
0.0022267497,
0.000010895899,
0.016097473,
0.009143528,
-0.035519864,
-0.005058337,
0.01863847,
-0.025734331,
0.02730218,
0.0108127445,
0.0053692036,
-0.02365288,
-0.019192621,
-0.016219117,
0.003139075,
-0.01016398,
-0.0024835523,
-0.009407088,
0.022733796,
0.02584246,
-0.0071499273,
-0.014529626,
-0.0023027768,
-0.0075080995,
-0.027761722,
-0.016097473,
0.0020020471,
-0.019841386,
-0.02716702,
0.013502415,
0.011306076,
0.00092246226,
0.026585836,
-0.008508278,
-0.025747849,
0.00061244064,
-0.014705333,
0.022990597,
-0.004652859,
0.010434299,
-0.0032691658,
0.016948977,
0.02062531,
-0.014651269,
0.00780545,
-0.00012829575,
-0.013123969,
0.002149033,
-0.01444853,
0.016421856,
-0.013536205,
0.01488104,
0.0001913349,
0.015151358,
0.0067005227,
-0.004058158,
-0.013907893,
0.00041286944,
0.0022943292,
-0.0037675656,
-0.0025291685,
-0.017651806,
-0.0020730058,
0.013144243,
-0.033870924,
-0.036222693,
0.010731649,
-0.011468267,
0.011785892,
-0.0061497483,
0.02192284,
0.005044821,
-0.014759396,
-0.004497426,
-0.023193337,
-0.029816143,
-0.0071769594,
0.020436088,
0.022166127,
0.024396256,
0.0031897596,
-0.011218223,
0.010170738,
0.011583152,
0.023842102,
-0.028734868,
0.018935818,
-0.02527479,
0.024031324,
-0.04314285,
-0.03222198,
-0.0055381525,
0.015408161,
0.013745702,
-0.012252191,
0.00644372,
-0.05025223,
0.09358431,
0.010285623,
-0.016746238,
0.014489078,
-0.0077378703,
0.03760132,
0.0021591699,
0.013414561,
-0.009062432,
-0.01886824,
-0.008609648,
-0.02766711,
0.022085031,
-0.0102248015,
0.00896782,
-0.00083165214,
-0.009184075,
0.016435372,
-0.02586949,
-0.044818826,
0.008629922,
-0.008251476,
0.004179802,
0.021368686,
-0.019544035,
0.01106279,
0.012340045,
-0.011529089,
0.011603426,
-0.034546718,
0.009346266,
-0.013123969,
-0.041791257,
-0.0061429907,
0.014651269,
-0.01488104,
-0.0066633536,
-0.010332929,
0.025193695,
0.02859971,
0.004902904,
-0.01581364,
-0.016151538,
-0.0011573016,
0.020044126,
-0.0041966964,
-0.005244181,
-0.009542247,
-0.014367434
] |
A series of 33 patients with combined (injurious) sleepwalking, sleep terrors, and rapid eye movement (REM) sleep behavior disorder (viz. "parasomnia overlap disorder") was gathered over an 8-year period. Patients underwent clinical and polysomnographic evaluations. Mean age was 34 +/- 14 (SD) years; mean age of parasomnia onset was 15 +/- 16 years (range 1-66); 70% (n = 23) were males. An idiopathic subgroup (n = 22) had a significantly earlier mean age of parasomnia onset (9 +/- | [
0.008484416,
-0.0028367348,
0.032029316,
-0.022861503,
-0.028883118,
0.008387709,
-0.00044807515,
-0.013590539,
-0.025775604,
0.0035169064,
-0.015576253,
0.021559184,
0.011185762,
-0.0073626162,
-0.0013788788,
0.014660762,
0.023570688,
0.0038199213,
0.015679408,
0.013487385,
-0.009225835,
-0.001885784,
-0.018980335,
-0.0049836272,
-0.007543136,
0.01914796,
0.017136456,
-0.020901578,
0.020166606,
-0.01262347,
-0.0014457677,
-0.03623284,
-0.012810437,
-0.00070636306,
-0.026587943,
-0.026510576,
0.009129128,
-0.0038392628,
0.018129315,
-0.016066235,
0.014132097,
-0.010308952,
-0.01769091,
0.0027222983,
0.01060552,
0.010940771,
-0.008329685,
-0.026046384,
-0.017316977,
0.022062061,
0.010753804,
0.021778386,
-0.029398888,
0.0075882655,
0.011740214,
-0.0139773665,
0.025169574,
0.029579408,
0.014699444,
-0.034298703,
0.005244736,
-0.006466466,
-0.017110668,
0.0070531545,
-0.0028464056,
0.0042970087,
-0.013538961,
-0.0076462897,
0.002902818,
-0.0005919266,
0.059829317,
0.020656588,
-0.0012072241,
-0.008239426,
0.0064019947,
-0.008800325,
0.006011944,
-0.00990923,
-0.0044388454,
-0.004993298,
0.0019744318,
-0.019831356,
-0.037393324,
0.012423609,
0.004077806,
-0.012752413,
-0.018954547,
0.022500465,
-0.013848424,
0.011134184,
0.012520316,
0.019328479,
-0.012726624,
-0.0028093345,
-0.011327598,
0.009638451,
-0.015666513,
0.012649259,
-0.013693693,
-0.006157004,
0.00055243797,
0.003932746,
-0.029166792,
-0.008626252,
-0.011237338,
-0.0130167445,
-0.0050835577,
0.01735566,
0.0059700375,
-0.014622078,
-0.019625047,
0.030430429,
0.0019099606,
-0.015344157,
-0.012791095,
0.019547682,
0.013126345,
0.018567719,
-0.009032422,
-0.025956124,
0.028986271,
-0.004522658,
0.0076205013,
-0.022139426,
-0.00012430862,
-0.0012588011,
-0.011308257,
-0.011527459,
0.007768785,
-0.021004733,
-0.018503247,
0.007807468,
0.035484973,
-0.0046322593,
-0.015279685,
0.032699816,
-0.0010549107,
-0.013158581,
-0.042499445,
-0.008271661,
0.01878692,
0.016582005,
-0.027593693,
-0.020927366,
-0.004326021,
0.019844249,
0.02749054,
0.0061312155,
-0.004168066,
-0.004948168,
-0.004512987,
0.0022887292,
-0.0026288151,
0.020437386,
0.016478851,
0.015950186,
0.014944435,
0.033189796,
-0.027954733,
0.011740214,
-0.019973192,
0.010824722,
-0.0006414889,
0.008316791,
-0.0213013,
0.016427273,
0.001980879,
-0.0029189356,
0.017136456,
-0.004242208,
-0.010837616,
0.024924584,
-0.036103897,
0.012649259,
0.011778897,
0.019947404,
-0.005789518,
-0.0045710113,
-0.051293325,
-0.027129501,
-0.026716884,
0.002238764,
0.014699444,
0.0054478203,
-0.00035519627,
0.0058668833,
0.012185065,
-0.014157886,
-0.0083038965,
-0.004564564,
0.0060280617,
0.016607793,
0.009180705,
-0.009258071,
-0.6494576,
-0.01802616,
-0.009238729,
-0.003910181,
0.015176531,
0.011192208,
0.014119203,
0.009109787,
-0.016865678,
0.02029555,
-0.0146478675,
0.022655196,
0.011785344,
-0.029424677,
-0.0130167445,
-0.0034975652,
-0.03280297,
0.009748053,
0.020463174,
0.00553808,
-0.010579731,
0.008735854,
-0.01511206,
0.022268368,
0.004774096,
-0.0074335346,
0.012314008,
-0.018864287,
0.015292579,
0.007143414,
0.007768785,
0.018993229,
0.008735854,
0.015073378,
0.049384974,
-0.032364566,
0.001377267,
0.049049724,
0.0367744,
0.04876605,
-0.015460205,
-0.0012322067,
0.035974957,
-0.007846151,
-0.014918647,
0.0021791281,
-0.0022919527,
-0.021339983,
0.01665937,
-0.019650836,
0.006179569,
0.005812083,
0.0105926255,
-0.007723655,
0.024808535,
-0.0040165586,
0.0020018322,
-0.018477459,
0.007846151,
-0.019547682,
-0.009748053,
0.00961911,
0.0046354826,
0.0052576303,
-0.023493322,
0.023377273,
0.009348331,
-0.010489472,
0.014983118,
-0.013100557,
0.009535298,
0.04041058,
-0.031487755,
0.0076849726,
0.004048794,
0.0030430427,
0.025221152,
0.019805567,
-0.030146755,
-0.007336828,
-0.004074583,
0.019895827,
-0.020192394,
0.0007929963,
0.028702598,
-0.017665122,
-0.0046000234,
0.022526253,
-0.010960111,
-0.012739519,
0.021533396,
0.0070080245,
0.008149166,
-0.01417078,
-0.017484602,
0.018232469,
0.0023386944,
-0.00013821023,
-0.0041938545,
-0.017703803,
-0.01598887,
-0.010528155,
0.0016448227,
-0.008013776,
0.029063638,
0.008548887,
-0.0019905497,
-0.025440354,
0.04141633,
-0.017703803,
0.007098284,
-0.004699954,
0.009838312,
-0.024911689,
-0.019805567,
-0.019586364,
0.0002268582,
0.012185065,
-0.00166497,
-0.004454963,
-0.0019325257,
-0.012945826,
0.018051948,
-0.008890585,
0.0012588011,
0.006460019,
-0.00427122,
0.00014798166,
-0.0075302417,
-0.029244157,
-0.0024273423,
-0.008735854,
-0.005824977,
-0.0141449915,
-0.012462292,
-0.0050545456,
0.014583396,
-0.018890075,
0.024615122,
-0.013107005,
-0.015679408,
0.0022403758,
0.005592881,
0.00000999808,
-0.018400094,
-0.044871986,
-0.0008880914,
-0.013010298,
-0.004935274,
0.00304949,
0.011334045,
-0.007717208,
-0.0070080245,
-0.0044098333,
-0.0030913963,
-0.005612222,
-0.014789704,
-0.032080892,
-0.020050557,
0.013461596,
0.0068532936,
0.004242208,
-0.013693693,
-0.00025425848,
0.0018986783,
-0.01787143,
-0.012288219,
0.019521894,
-0.017845642,
-0.015150743,
-0.0006064327,
0.0015182978,
0.009702923,
-0.000015878562,
-0.007291698,
0.031384602,
-0.007607607,
-0.025117997,
-0.012649259,
-0.0043872683,
0.0052705244,
0.023248332,
-0.0031284671,
-0.004052018,
0.022036271,
0.008555334,
0.034969203,
-0.007349722,
0.013900001,
0.032596663,
-0.000059333695,
0.05271169,
-0.009445038,
0.01309411,
0.008845455,
0.010586179,
0.023248332,
0.010399212,
0.026691096,
0.029605197,
0.0136421155,
0.007807468,
-0.0031768207,
-0.0038038036,
0.016788313,
-0.024202505,
0.019186642,
-0.01769091,
0.039353248,
0.011005241,
-0.006157004,
0.0059378017,
0.0050480985,
-0.018039055,
-0.0005242318,
0.018774027,
-0.006692115,
0.014570502,
-0.021352876,
-0.011901392,
-0.0022290933,
-0.011488776,
0.008561782,
0.017678015,
-0.011920733,
0.01605334,
0.027774213,
0.0047321892,
0.035407607,
0.0034524351,
-0.021494713,
0.0067888224,
0.0098641,
0.047528204,
-0.0023403063,
0.0063471943,
0.014119203,
-0.011276021,
0.0105926255,
0.01589861,
-0.0111406315,
0.025814287,
0.041828945,
-0.029063638,
-0.0224231,
0.0021049862,
0.008961503,
0.010850511,
-0.0033944112,
-0.00096948637,
0.0077301026,
-0.0070724958,
-0.03213247,
0.010553943,
-0.030120967,
0.0020759741,
-0.006982236,
-0.0029431123,
0.023377273,
0.019083489,
0.017652227,
-0.0066985623,
0.009651345,
-0.0020082793,
0.015047588,
-0.0042454316,
-0.0099672545,
0.009335437,
0.021494713,
-0.025724027,
-0.0153957335,
0.0056766933,
0.008516652,
-0.023196755,
0.00905821,
-0.0048740264,
0.0015593983,
0.0020340679,
0.018554825,
0.019560575,
-0.030997775,
-0.031229872,
-0.006002273,
-0.003558813,
0.0024547428,
-0.0025740145,
-0.0069886832,
0.008606912,
-0.004322797,
0.009677134,
-0.0016504639,
0.007240121,
-0.024911689,
-0.006044179,
0.02224258,
0.007755891,
0.037805937,
-0.026845828,
0.006427783,
-0.008046011,
-0.0002798455,
0.012056123,
-0.008993739,
-0.014583396,
-0.0034427645,
-0.00021759045,
-0.029811503,
-0.009283859,
-0.016981727,
0.017587757,
0.009728711,
-0.007124073,
-0.0139773665,
0.023441745,
-0.022925975,
-0.00066324795,
-0.0123913735,
-0.02215232,
0.00257885,
-0.0077365497,
-0.004042347,
-0.025234045,
-0.020862896,
0.007904175,
0.034969203,
0.04100371,
0.008658488,
0.02988887,
0.018051948,
-0.0024644134,
-0.032364566,
-0.030662525,
0.03179722,
0.011759555,
-0.006540608,
-0.011005241,
0.04894657,
0.0039810995,
0.0029286065,
0.006295617,
0.00858757,
-0.012455844,
-0.013796846,
0.009677134,
-0.012281773,
-0.011011689,
0.017794063,
0.07220779,
0.026059277,
-0.032235622,
0.017652227,
0.02369963,
-0.008142718,
-0.011417857,
-0.023390168,
-0.0033782932,
0.002246823,
0.048972357,
0.003955311,
0.0034524351,
0.010927876,
-0.008220084,
0.009000186,
-0.012649259,
0.02800631,
0.013693693,
0.008980844,
-0.00072812213,
0.022655196,
-0.0077816793,
-0.001083117,
0.007543136,
-0.002143669,
0.004957839,
0.007349722,
0.020501856,
-0.021339983,
-0.022268368,
0.00558321,
0.0021710692,
0.0037747915,
-0.018902969,
-0.012449398,
-0.009748053,
0.008065353,
-0.031126717,
0.019264009,
-0.0039230753,
-0.020140817,
-0.037522264,
0.0088841375,
-0.0023064588,
-0.015602042,
-0.020140817,
-0.00849731,
-0.009116234,
-0.02072106,
0.0021839635,
0.011172867,
0.016001763,
0.0017890771,
-0.012049676,
0.009296753,
0.018464565,
-0.0093870135,
-0.002151728,
0.0020937037,
0.023570688,
0.024163824,
0.009477274,
0.009503062,
-0.014196568,
-0.008690724,
0.02284861,
0.0063407472,
-0.005457491,
0.0070209187,
-0.0028705823,
0.005422032,
-0.00811693,
0.0023080707,
0.03690334,
-0.011295362,
-0.015782561,
0.022990447,
-0.027903154,
-0.01562783,
-0.0044807517,
0.0014401264,
0.010431448,
-0.009277413,
-0.010869852,
-0.024434602,
-0.018322729,
0.004661271,
-0.006089309,
0.0018213127,
0.012803989,
0.024898795,
0.013487385,
-0.025646662,
0.027052134,
0.020076346,
-0.0057476116,
-0.0101800095,
0.020140817,
0.019947404,
0.009109787,
-0.017097775,
0.023042023,
0.016272543,
-0.008980844,
-0.035433397,
-0.012565446,
-0.014248146,
0.038502228,
-0.0015585924,
-0.034608167,
-0.047192954,
-0.009735158,
-0.013197264,
0.011695084,
-0.0050384277,
0.0009066269,
0.0009557862,
0.021365771,
-0.022487571,
-0.015550464,
0.037548054,
-0.02157208,
-0.008755195,
-0.022835715,
-0.022474676,
0.023918832,
-0.008452181,
0.028960483,
0.009361225,
0.007942857,
0.0059378017,
-0.01650464,
-0.014132097,
-0.0053349957,
0.05704416,
0.0059023425,
0.01872245,
0.0017665122,
0.0023773771,
0.030765679,
-0.00034250348,
-0.0019131842,
-0.0055219624,
0.0115983775,
-0.014273934,
0.021958906,
-0.0002113448,
0.03708386,
-0.00047628133,
-0.020192394,
0.049488127,
0.023325697,
-0.01607913,
-0.01699462,
-0.018232469,
-0.033241376,
0.01027027,
-0.008174954,
-0.0010371811,
0.011579036,
-0.039198518,
-0.00050932285,
0.020656588,
0.015318368,
-0.007336828,
-0.020231077,
0.02336438,
-0.023557793,
0.008213636,
-0.028986271,
0.012745965,
0.00044686632,
-0.014802598,
-0.009799629,
0.0065309373,
0.011456541,
-0.0039972174,
-0.006260158,
0.021468924,
0.012094806,
-0.012281773,
-0.0037651209,
-0.013758164,
-0.005422032,
0.0004079821,
-0.0021372219,
0.0014497972,
0.0026546034,
-0.013500279,
-0.008484416,
-0.007311039,
0.0148928575,
-0.022603618,
0.028547868,
-0.033447683,
-0.003542695,
-0.00665988,
-0.0034298704,
0.013371336,
0.0026997335,
0.02800631,
0.011282468,
-0.0131392395,
-0.009129128,
0.028728386,
0.02576271,
0.0032009974,
0.026820038,
0.015795454,
-0.012945826,
0.00030825313,
-0.013564751,
-0.0053059836,
-0.046445087,
-0.05175752,
0.017987479,
0.011192208,
-0.018284045,
-0.007143414,
0.007149861,
-0.017729593,
0.033292953,
-0.01896744,
0.006476137,
0.01607913,
-0.0017358883,
-0.019805567,
0.02318386,
-0.029837294,
-0.013371336,
0.00003467848,
0.015589147,
-0.0040552416,
-0.014389982,
-0.017097775,
0.016633581,
0.0025385553,
0.014041837,
-0.016130706,
-0.007143414,
-0.013538961,
0.021198146,
-0.009322542,
-0.0023048471,
-0.041725792,
0.032931913,
0.0024853665,
0.007936411,
0.0049384977,
0.0011911063,
-0.0035620364,
0.0009066269,
-0.013397125,
-0.021120781,
0.0005750029,
-0.0092193885,
0.024834324,
0.017587757,
-0.0009670687,
-0.013358442,
-0.034118183,
-0.010908535,
-0.00943859,
-0.033937663,
0.002327412,
-0.034633953,
0.011082607,
-0.017368553,
0.018000372,
0.04229314,
0.0036200604,
0.0055348566,
0.0034653295,
0.024924584,
-0.005186712,
-0.0042679966,
-0.010747356,
0.023854362,
-0.008845455,
-0.006924212,
-0.0070724958,
-0.029940447,
0.02051475,
0.014854175,
-0.028496291,
-0.021713916,
0.0070660487,
0.0046322593,
-0.011901392,
-0.02033423,
0.021262618,
0.00074343407,
-0.011482329,
-0.0009920513,
-0.03089462,
0.005509068,
0.0002687645,
0.0029769598,
-0.0003433094,
-0.019844249,
0.02630427,
-0.010276716,
0.007891281,
-0.0038457098,
-0.029347312,
-0.0050190864,
-0.030636735,
0.02378989,
-0.03535603,
-0.017923007,
-0.009135576,
-0.018412989,
-0.01863219,
0.015034694,
-0.0039520874,
-0.032751393,
-0.01878692,
0.015086272,
-0.0005923296,
0.015885714,
0.020256866,
0.011907839,
0.019599259,
-0.017071987,
-0.032880336,
-0.022139426,
-0.020282654,
0.038192768,
0.023648053,
-0.033731356,
0.0037747915,
-0.025943229,
-0.020231077,
0.012797542,
0.004973957,
0.030585159,
0.02318386,
0.011604824,
0.0022355404,
0.017213823,
0.010708674,
0.011475882,
-0.034582376,
-0.003113961,
0.020978944,
0.0039424165,
0.0009001798,
-0.00901308,
-0.032055102,
0.0197282,
0.030585159,
-0.014570502,
-0.025466142,
-0.006295617,
-0.0070015774,
-0.008432839,
-0.00957398,
0.0010734462,
-0.02345464,
-0.02919258,
-0.012481634,
-0.037315957,
-0.0019776556,
-0.009625557,
-0.0023806007,
-0.019031912,
-0.021533396,
0.024434602,
-0.019186642,
-0.0038553805,
-0.02029555,
-0.014506031,
-0.0011999711,
-0.030249909,
0.016530428,
0.022203898,
0.0077301026,
0.029863082,
-0.0050996756,
0.015434416,
-0.012236643,
0.018438777,
0.013165029,
-0.013874212,
0.011791791,
-0.012765307,
0.008084694,
-0.0008123377,
0.01036053,
-0.0025595084,
0.009748053,
-0.02591744,
-0.0042615496,
-0.025105104,
0.02816104,
0.024021987,
-0.035407607,
0.005950696,
0.011566142,
-0.011153526,
0.0031752088,
-0.007330381,
-0.0052608536,
-0.012159277,
0.0059442488,
-0.0061505567,
-0.005228618,
0.02676846,
0.00332994,
-0.0125138685,
-0.015189426,
0.010437895,
0.18371727,
0.0025385553,
-0.0048869206,
0.009361225,
0.023312803,
-0.016491745,
0.03894063,
0.006679221,
-0.0183872,
0.022474676,
0.008581123,
-0.02148182,
0.005786294,
0.010869852,
-0.003903734,
-0.020862896,
-0.03723859,
-0.018167997,
-0.02020529,
-0.014789704,
0.016607793,
-0.026665308,
-0.026239797,
-0.007491559,
0.012694389,
0.018284045,
-0.011159972,
-0.005828201,
0.019367162,
0.035846014,
-0.0019131842,
-0.0038199213,
-0.0071820966,
0.002348365,
-0.040771615,
-0.0028786412,
0.0032719157,
-0.013667904,
-0.010760251,
0.020978944,
-0.012010993,
0.005789518,
0.013132793,
-0.004161619,
-0.00036184487,
0.00910334,
-0.015124954,
-0.018000372,
-0.0028738058,
-0.0094321435,
-0.042525236,
-0.002480531,
0.009135576,
0.014441559,
0.00021335953,
0.0005508262,
0.021430243,
0.0206308,
-0.002156563,
0.014093414,
0.01215283,
0.0066405386,
-0.051628575,
0.018335622,
-0.00008597845,
0.044949353,
0.0005548557,
0.024021987,
-0.009167811,
-0.029656773,
-0.008329685,
-0.008703618,
-0.039533768,
0.010753804,
-0.006930659,
-0.034427647,
0.052918,
0.011250232,
-0.010676438,
0.027516328,
-0.020411596,
-0.0029560067,
-0.01417078,
-0.0028496291,
-0.046857703,
-0.02867681,
0.019637942,
0.0071756495,
-0.0023580359,
-0.026201114,
0.002548226,
-0.018490354,
0.009748053,
0.016182283,
0.0019873262,
-0.0022774467,
0.022474676,
0.022732561,
-0.00038239508,
-0.019921616,
-0.004699954,
0.03419555,
0.031668276,
0.004964286,
-0.027954733,
-0.004306679,
-0.00045170166,
0.01338423,
0.02482143,
-0.022178108,
0.002923771,
-0.009638451,
0.027413175,
-0.008484416,
0.009045316,
0.035149723,
0.01257834,
-0.007240121,
-0.0042067487,
-0.019895827,
-0.015163637,
-0.037470687,
0.016685158,
0.014041837,
-0.0055058445,
-0.017304083,
0.00047466956,
-0.0053511136,
-0.005373678,
-0.025620874,
0.0031316907,
-0.025388777,
0.002372542,
-0.009664239,
0.000758746,
-0.022771245,
0.0016472404,
0.017007515,
0.018051948,
-0.004396939,
0.0004980404,
-0.00260625,
0.012475186,
0.014493136,
-0.00995436,
-0.011662848,
-0.014132097,
0.021546291,
-0.0069564474,
-0.000089101275,
-0.022294156,
-0.014828387,
0.013461596,
0.005737941,
0.02172681,
-0.023854362,
-0.016582005,
-0.027877366,
-0.022294156,
0.00478699,
-0.025040632,
-0.0016303166,
0.013680798,
-0.012307561,
0.0013667904,
-0.005979708,
-0.16122968,
0.0030430427,
0.011443647,
-0.029295735,
0.015872821,
0.0036039427,
0.033267163,
-0.0002746072,
-0.020953154,
-0.01665937,
0.026897404,
0.012139936,
-0.030095177,
-0.0021049862,
0.01829694,
0.016865678,
-0.0018712779,
0.0412616,
0.03435028,
0.016169388,
0.044072542,
-0.023338592,
-0.000045205423,
-0.0038940632,
0.004748307,
0.010792486,
0.014879963,
0.024511967,
0.0014272322,
-0.03435028,
-0.05462004,
0.006495478,
0.0033976347,
-0.010296058,
-0.008684277,
-0.009748053,
-0.005148029,
-0.006318182,
-0.013152135,
0.018619295,
0.012462292,
0.012842672,
0.01948321,
0.016917255,
0.008703618,
0.0065696198,
0.016685158,
-0.0025014842,
-0.007504453,
-0.014235252,
-0.024254084,
-0.016710946,
0.029347312,
-0.0022484348,
-0.00066808326,
0.0029253827,
0.015666513,
-0.015859926,
0.003926299,
-0.012146383,
-0.0014562443,
-0.029914659,
0.037470687,
-0.0052125,
0.0026642743,
-0.008110483,
-0.004087477,
0.000015714866,
0.003549142,
0.014389982,
-0.009741605,
0.0033105984,
-0.020617904,
-0.025440354,
0.012604129,
0.008232978,
-0.0044420687,
0.015047588,
0.0061441096,
-0.010869852,
-0.012210854,
0.033086643,
-0.022384416,
0.029115215,
-0.00007948096,
0.00029515743,
-0.0044291746,
0.01253321,
-0.004103595,
-0.022900186,
-0.009580427,
-0.0053801257,
0.027258443,
-0.00269651,
0.006692115,
0.007833256,
-0.009986596,
-0.008664936,
0.0017423354,
-0.00455167,
0.006872635,
-0.0041487245,
-0.002593356,
0.0179359,
0.018993229,
-0.021043414,
0.0049965214,
-0.005044875,
0.016285436,
-0.017484602,
-0.011089054,
-0.0065663964,
-0.0038134742,
0.004522658,
-0.011746661,
0.015614936,
-0.001980879,
-0.008149166,
0.018064843,
-0.0028738058,
0.059004083,
-0.011269574,
0.012675047,
0.0065728435,
-0.019341374,
-0.0068532936,
-0.11501671,
0.008361921,
-0.0016174224,
0.030146755,
-0.005360784,
0.010018832,
0.002038903,
0.014273934,
0.015241003,
0.026046384,
-0.0043195733,
-0.022126531,
0.009947914,
-0.0014546325,
0.01760065,
-0.0042679966,
0.02275835,
-0.030456217,
-0.03055937,
0.064161785,
0.0008872855,
0.00952885,
0.009090446,
-0.024576439,
-0.02697477,
-0.012526763,
-0.034814473,
-0.0023918832,
0.0023548123,
0.035149723,
-0.010676438,
-0.0033976347,
0.00015664498,
0.012243089,
-0.008613358,
-0.011172867,
-0.025388777,
0.0049159327,
0.020566327,
-0.025143785,
0.02033423,
0.014106309,
-0.0039746524,
0.022435993,
0.0036909787,
0.0058507654,
-0.031126717,
0.014467347,
0.008194296,
-0.017806958,
0.0048192255,
-0.0006390712,
-0.012159277,
-0.02172681,
0.0019502552,
0.005641234,
0.006827505,
0.012655705,
-0.00562834,
0.022951763,
-0.008349027,
0.01887718,
-0.01036053,
0.014183674,
0.00047386365,
-0.0049449448,
-0.027464751,
-0.021946013,
0.0072143325,
-0.006266605,
-0.023738313,
0.0021936342,
-0.0017520061,
-0.0006314153,
-0.034994993,
0.013397125,
-0.0022049167,
-0.017278293,
-0.000077315126,
-0.009651345,
0.004326021,
0.0004279279,
0.000029515742,
0.010205798,
0.024679594,
0.014918647,
0.0073626162,
-0.022680985,
0.0039456403,
0.0028496291,
0.003152644,
0.021971801,
-0.009993043,
-0.011172867,
0.0114307515,
0.011791791,
-0.020927366,
-0.018464565,
0.0032783628,
0.031229872,
-0.00455167,
-0.01262347,
-0.046316143,
0.028393136,
0.023158072,
0.0016004987,
0.0010283163,
0.0061505567,
0.032570872,
-0.00003309188,
-0.00021698604,
-0.007878386,
-0.004013335,
0.0059926026,
-0.04788924,
0.0076978668,
-0.03997217,
-0.004545223,
0.0072014383,
0.021842858,
0.04365993,
-0.0082587665,
-0.015137848,
0.026587943,
0.0026320387,
0.048508167,
0.0061634514,
-0.021933118,
-0.0014328734,
0.014905752,
-0.015344157,
0.006866188,
0.012771754,
-0.023776995,
-0.01878692,
0.016027551,
-0.016620688,
-0.03195195,
0.0066985623,
0.01520232,
0.0041970783,
0.023106495,
-0.024189612,
-0.039869018,
0.02455065,
-0.03435028,
0.0056089982,
0.009915678,
-0.010412106,
0.006885529,
0.0021130452,
-0.012604129,
0.019960297,
0.010960111,
-0.027464751,
-0.012907144,
-0.032777183,
0.014854175,
-0.0038457098,
-0.0017858535,
0.011991652,
-0.027000558,
0.015150743,
-0.013397125,
0.0021178804,
-0.02524694,
0.013758164,
-0.021804176,
-0.0132295,
0.0094321435,
-0.0067565865,
-0.0080911415,
0.0039843232,
0.006221475,
0.024744064,
0.018400094,
-0.0018180892,
-0.00628917,
-0.043427832,
0.018645084,
-0.0112631265,
0.017368553,
0.032029316,
-0.0006265799,
-0.04329889,
0.0053188778,
0.012004546,
0.010289611,
-0.024860112,
0.047167163,
-0.017574862,
0.0011459764,
-0.019418739,
-0.009838312,
0.0030091954,
-0.009690029,
-0.0061763455,
0.032003526,
-0.010489472,
-0.0010927876,
0.051551208,
0.018309833,
-0.012546104,
-0.0039939936,
-0.02078553,
-0.050854918,
0.0024289542,
-0.012984509,
-0.024950372,
-0.017910112,
0.006231146,
0.0012136712,
0.017381448,
0.027851578,
-0.03383451,
0.020656588,
0.01708488,
-0.012384926,
-0.002682004,
-0.011662848,
-0.020037664,
0.023441745,
0.0065889615,
0.03486605,
0.011443647,
-0.014828387,
-0.0044066096,
0.0007345693,
0.0141449915,
-0.011856263,
0.02069527,
-0.006227922,
0.0032525745,
-0.011346939,
-0.032570872,
0.0029656773,
0.0004396133,
-0.043892026,
0.021623656,
0.01872245,
0.017188035,
0.06885529,
0.00081636716,
-0.018374305,
0.014235252,
-0.021920223,
0.0077881264,
0.0028657469,
0.00474186,
-0.016285436,
-0.028702598,
0.00708539,
-0.018245362,
0.023145176,
-0.017136456,
-0.004351809,
-0.006518043,
-0.006076415,
0.016723841,
0.012655705,
-0.012127042,
0.053846385,
-0.026948981,
0.021675233,
0.019122172,
-0.0027819343,
-0.012726624,
0.045490913,
0.01589861,
-0.02439592,
-0.02412514,
-0.0041777366,
-0.0009678746,
-0.017110668,
-0.0041841837,
0.0071563083,
-0.008387709,
-0.0029963013,
-0.025479037,
0.0046870597,
-0.0030978434,
-0.028805753,
0.018954547,
-0.016375696,
0.010837616,
0.00816206,
-0.004425951,
0.0052253944,
-0.01751039,
-0.031694066
] |
BACKGROUND Patient experience is increasingly used to assess organizational performance, for example in public reporting or pay-for-performance schemes. Conventional approaches using 95% confidence intervals are commonly used to determine required survey samples or to report performance but these may result in unreliable organizational comparisons. METHODS We analyzed data from 2.2 million patients who responded to the English 2009 General Practice Patient Survey, which included 45 patient experience questions nested within 6 different care domains (access, continuity of care, communication, anticipatory care planning, out-of-hours care, and overall care satisfaction). For each question, unadjusted and case-mix adjusted (for age | [
0.016028896,
0.0048599667,
0.025515659,
-0.045754973,
-0.008027772,
0.025302473,
0.007068437,
0.0013948671,
-0.042717077,
-0.017481225,
-0.0204525,
0.018520504,
-0.014216819,
-0.002006943,
-0.011019033,
0.0006070795,
0.038266826,
-0.004097162,
-0.0061490736,
-0.017134797,
-0.032830592,
0.010486069,
-0.036481395,
0.015415988,
-0.007974476,
0.006442204,
0.019013496,
-0.029366324,
-0.01782765,
-0.013337428,
-0.0040904996,
0.007168368,
-0.035415467,
-0.003720756,
-0.01688164,
0.009833189,
0.012124934,
0.0015789063,
0.026981309,
-0.007981138,
0.008300916,
0.0028646823,
0.0014231808,
0.018613772,
0.012537981,
0.0107458895,
0.0037873765,
-0.013204186,
-0.010885793,
0.017321335,
0.00065121555,
0.01029287,
-0.02428984,
-0.0073815533,
0.030458901,
-0.012184893,
0.010579338,
0.008134365,
-0.0007594739,
-0.018054161,
-0.00001290122,
0.011338812,
-0.020372555,
-0.0012957691,
-0.039439347,
-0.007061775,
0.006142412,
-0.00041741919,
0.025982002,
0.0065088244,
0.03418965,
0.0349358,
-0.013464007,
0.005266352,
0.04010555,
-0.0060358187,
-0.012064976,
-0.011998355,
0.002061905,
0.026035298,
-0.005136442,
-0.014363384,
-0.004227072,
0.019453192,
-0.0049965386,
0.0112855155,
0.0023433766,
0.014230142,
0.0010584334,
-0.011019033,
0.024529675,
0.012164907,
0.00474005,
0.013190863,
0.0021251945,
0.0036341492,
0.017228065,
0.020412527,
0.0030928575,
-0.024569647,
-0.010665945,
0.03240422,
-0.03432289,
-0.013657207,
-0.018786985,
-0.0067753065,
-0.026501643,
0.0045268643,
0.0050964695,
0.009679961,
-0.030245716,
0.029739399,
-0.018227374,
0.009007094,
0.0038806451,
-0.011925072,
-0.013910364,
0.0017870954,
-0.016775046,
-0.008021111,
0.009899809,
0.0044102785,
0.041517906,
-0.0035641978,
0.012591278,
0.011352137,
-0.008027772,
-0.0012999328,
0.01159197,
0.009206955,
-0.014922996,
0.00958003,
0.02718117,
0.016375324,
-0.023716904,
0.012331458,
0.00070118095,
0.006308963,
-0.024876101,
-0.029925937,
-0.015882332,
0.014056929,
0.0033093742,
-0.0017654437,
0.00006672461,
0.030192418,
0.040984944,
0.003460936,
0.0033793258,
-0.010279546,
0.022224605,
-0.014922996,
-0.019013496,
0.029606158,
0.014216819,
-0.012937705,
0.0046900846,
0.042583834,
-0.016335351,
-0.024889426,
-0.020372555,
0.017920919,
0.0017437921,
-0.006305632,
-0.014589894,
0.010699255,
0.0046501122,
0.0035408805,
0.0030045854,
-0.006199039,
-0.032644052,
0.029126491,
-0.01828067,
0.026967986,
0.0068818997,
0.020639036,
-0.028513582,
0.027394356,
-0.023223912,
-0.02600865,
-0.028113859,
0.016615158,
0.024236545,
0.010939089,
-0.028726768,
-0.023610312,
0.019346599,
-0.0005621106,
0.013777123,
0.0063389423,
0.015655821,
0.023303857,
0.015336043,
-0.012624588,
-0.6502163,
-0.023650283,
0.024956046,
-0.0022251252,
0.029126491,
0.02191815,
0.014789755,
-0.0049066013,
-0.024862777,
0.02217131,
0.0071617058,
0.017974216,
0.045275304,
-0.022624329,
-0.028620174,
-0.011685239,
0.005043173,
-0.002051912,
0.018373938,
-0.027061254,
-0.0046967464,
0.035761893,
-0.000027220727,
-0.007981138,
-0.008780585,
0.023796849,
0.019533135,
-0.020305933,
0.010832496,
0.009146997,
-0.015602525,
-0.0006470518,
-0.00097349234,
0.013763799,
0.044848934,
-0.0049499045,
0.002360032,
0.0014131877,
0.012204879,
0.029446268,
-0.0136372205,
-0.0067486586,
0.024423081,
0.002656493,
-0.027221143,
-0.0024682903,
0.0075680907,
-0.00042054203,
0.0037540663,
-0.0033876533,
-0.004500216,
-0.009699947,
-0.016521888,
0.017321335,
0.009753244,
0.0011300505,
0.027234469,
-0.011065668,
-0.0019103433,
-0.016628481,
-0.0011808487,
-0.00039306105,
0.003600839,
-0.028593527,
-0.0057660057,
0.041997574,
0.025515659,
0.0010342835,
0.008107717,
-0.001244971,
-0.011631942,
0.025075963,
-0.0066354037,
-0.018653745,
0.03032566,
-0.00027897343,
-0.008101055,
-0.003389319,
-0.029552862,
-0.005359621,
-0.004863298,
0.011032358,
-0.015509256,
0.008274268,
0.027580895,
0.023796849,
-0.020092748,
0.008414172,
0.0073215947,
-0.015029589,
0.020092748,
0.024409758,
0.008207648,
-0.030059177,
-0.012171568,
0.0092269415,
-0.0037074317,
-0.020252638,
0.022357846,
-0.028939953,
-0.02795397,
-0.005629434,
0.005302993,
0.0128044635,
0.0032244332,
0.008460806,
-0.0057426887,
0.012244851,
0.029606158,
-0.0200661,
0.0056993854,
0.009959768,
0.006162398,
-0.018080808,
0.014563246,
-0.030059177,
0.020172693,
0.012398078,
-0.033363555,
-0.026141891,
0.012931042,
-0.0143234115,
0.03370998,
0.0020952153,
0.026435021,
0.011958383,
0.00037203394,
-0.012098286,
0.017134797,
-0.010979061,
0.0012399744,
-0.013290794,
0.0032777295,
-0.0057893232,
0.0016088855,
-0.0010109664,
0.011638604,
-0.018600449,
0.006432211,
-0.043143447,
-0.008407509,
-0.011412094,
0.007714656,
-0.020559091,
-0.013910364,
-0.030698735,
-0.0036607974,
0.0022934114,
0.020865547,
-0.0067453273,
0.0037873765,
-0.040825054,
0.0039206175,
0.01947984,
0.001196671,
-0.0013240828,
0.019266654,
-0.021145353,
-0.026648207,
-0.00977323,
0.010619311,
0.023223912,
-0.027287764,
-0.017641114,
0.014549921,
-0.019986155,
-0.02532912,
0.0117252115,
-0.0098398505,
-0.031418238,
0.017654438,
-0.013230835,
0.0014914669,
0.02273092,
-0.011265529,
0.012937705,
-0.01516283,
-0.019226681,
0.0115053635,
-0.019826267,
0.008121042,
0.016668454,
-0.021078732,
-0.0007744635,
0.024862777,
-0.0011633608,
0.0077612903,
0.029472917,
-0.00054420636,
-0.0032843915,
0.005769337,
0.0068818997,
-0.026035298,
0.030378956,
-0.027421005,
0.0046134708,
-0.012104948,
-0.004763367,
-0.010019726,
0.0075281183,
0.022970755,
0.016921612,
0.012751167,
-0.003337688,
0.026874717,
-0.0064821765,
0.005179745,
-0.015336043,
0.010939089,
0.010905779,
0.009320211,
-0.028886657,
-0.015802387,
-0.009533396,
-0.023796849,
0.016415296,
0.0061224257,
0.02503599,
0.00047883496,
0.0006853586,
-0.0052996622,
-0.00047300567,
0.025302473,
0.0068885614,
0.007055113,
-0.007954489,
-0.0044102785,
0.014803079,
0.025888734,
-0.0026148553,
-0.008740612,
0.01925333,
0.020572416,
0.011118964,
0.0334435,
0.021065408,
0.038879734,
-0.017334659,
0.035628654,
0.012491347,
0.0013698844,
0.006055805,
0.0033809913,
-0.011691901,
0.000642888,
-0.013817095,
0.018493855,
0.025808789,
-0.02393009,
-0.0094801,
-0.0060957773,
0.0083209025,
-0.0029446268,
0.022397818,
-0.006432211,
-0.009346859,
0.0096200025,
0.004490223,
0.041544557,
0.014829727,
0.019146737,
0.004463575,
0.030858625,
-0.0009901475,
0.010725903,
-0.008187662,
-0.02071898,
-0.028993249,
0.012524657,
-0.005406255,
0.01123222,
-0.028033914,
0.017481225,
-0.01931995,
0.0016954922,
0.01613549,
-0.0011200574,
-0.01983959,
0.0040505277,
-0.0057526818,
-0.026395049,
-0.023130644,
0.033097073,
0.020332582,
-0.0012841105,
-0.007854559,
0.0011133954,
0.00970661,
-0.03376328,
0.023103995,
-0.005669406,
0.005885923,
-0.0013174207,
-0.03821353,
0.019146737,
0.02275757,
0.012178231,
0.010039712,
-0.000298335,
0.012005017,
0.003490915,
-0.008893839,
-0.012224865,
-0.03496245,
0.03243087,
-0.0029629476,
-0.032297626,
-0.036348153,
-0.030698735,
-0.008334227,
0.00935352,
-0.007608063,
-0.021318566,
-0.011192247,
0.01367053,
-0.010685931,
-0.022850838,
0.0052630208,
0.044076134,
0.0016888301,
-0.006811948,
-0.012537981,
-0.0022817526,
0.007954489,
0.053589545,
0.01129884,
0.0077812765,
0.018906903,
-0.008141028,
-0.01584236,
-0.027127875,
-0.014749783,
-0.0063489354,
0.010659283,
-0.010539366,
0.014310087,
0.042344,
0.010219587,
0.024836129,
0.022944106,
0.011398771,
-0.015749091,
-0.012224865,
0.024849454,
0.0071350574,
-0.0032027813,
0.028780064,
0.04165115,
0.030831976,
-0.016122166,
0.036774527,
0.013610572,
0.002834703,
-0.028353693,
-0.021211972,
0.024809482,
-0.013657207,
0.008267607,
-0.03107181,
0.025449038,
0.018880256,
-0.0072616367,
0.018387264,
-0.017148122,
-0.0007307438,
-0.0013399052,
0.005156428,
-0.0237702,
0.005273014,
-0.025155907,
0.0077346424,
0.014083577,
0.00772798,
-0.0043369955,
-0.004150458,
-0.011878438,
0.0005308823,
-0.026488317,
-0.0010617645,
-0.008287593,
-0.01223819,
-0.01331078,
-0.035255577,
-0.012258176,
-0.009533396,
-0.020252638,
-0.0130243115,
-0.022118011,
-0.031924553,
-0.029126491,
-0.024183247,
-0.007448174,
-0.010139643,
0.004780022,
-0.014043605,
-0.01841391,
-0.014576569,
0.029419621,
0.027767433,
0.0012807795,
0.0129510285,
-0.005379607,
0.023956738,
0.013110918,
-0.0029596165,
0.017920919,
0.0044269334,
-0.005559482,
-0.010399463,
0.00248328,
-0.0041970927,
-0.019599756,
-0.007115071,
-0.0030861956,
-0.0053762756,
-0.011965045,
-0.0076014013,
0.000033648565,
0.0092869,
0.022477763,
0.00655879,
0.015695794,
0.0071217334,
-0.031551477,
-0.0045135403,
-0.026488317,
-0.00844082,
-0.014776431,
0.019426543,
0.009633327,
-0.020225989,
-0.003740742,
0.014509949,
-0.053109877,
0.017721057,
-0.013250821,
-0.00010003487,
-0.01178517,
0.011305502,
0.01055269,
0.009273577,
0.034269594,
0.026221836,
-0.008061083,
-0.0026431691,
0.010652621,
0.016188785,
-0.0008985442,
-0.016055545,
0.006055805,
-0.015056237,
-0.005636096,
-0.04530195,
-0.034136355,
0.005516179,
0.021172,
-0.010232911,
-0.01947984,
-0.025022667,
-0.013464007,
-0.006055805,
0.015136181,
0.0032627399,
-0.0063489354,
-0.022957431,
-0.005273014,
0.00568273,
-0.0007636377,
0.036934417,
-0.025728844,
-0.014776431,
0.0130243115,
-0.026101919,
0.028140508,
0.008827219,
0.0021934805,
-0.0053496277,
0.0022317874,
-0.014816403,
-0.02750095,
0.0017621127,
0.0010101337,
0.03464267,
0.026714828,
0.01798754,
-0.0033759947,
0.0013748809,
0.019799618,
-0.0058326265,
-0.0053562894,
-0.009633327,
-0.007947828,
0.0017171438,
0.004710071,
-0.0036974389,
0.0065154866,
0.0096200025,
-0.013010987,
0.020825574,
0.012324796,
-0.0047267256,
-0.024716211,
-0.03285724,
-0.014310087,
0.01211161,
0.001152535,
-0.02766084,
0.01581571,
-0.0460481,
0.003077868,
0.002444973,
0.004626795,
0.0040305415,
-0.03698771,
0.03437619,
-0.022984078,
0.019506488,
-0.011378785,
0.00821431,
-0.025995325,
-0.031444885,
-0.029472917,
0.013976985,
0.013883716,
0.007608063,
0.03997231,
0.0076480354,
0.0025149246,
-0.00993312,
0.008887177,
-0.03581519,
-0.0022934114,
0.001490634,
-0.02467624,
0.000516309,
-0.0039139553,
-0.0024882765,
-0.0072416505,
-0.0018886917,
0.027447654,
0.0028113858,
0.02139851,
-0.045728322,
-0.012757829,
-0.0131975245,
-0.009040404,
0.021651668,
-0.0016888301,
0.022237929,
-0.0007632213,
-0.0136372205,
-0.008547412,
0.012997663,
0.006685369,
0.0023567008,
0.03879979,
0.017547844,
-0.011445405,
-0.010053036,
-0.0059558745,
0.013657207,
-0.01289107,
-0.03402976,
0.022331197,
0.0065254797,
-0.007454836,
-0.013250821,
-0.0047067394,
-0.028113859,
0.04399619,
0.004510209,
-0.002814717,
0.010559352,
-0.011052344,
-0.0023350492,
0.014763107,
-0.008900501,
0.02259768,
-0.020492472,
-0.0128777465,
-0.0134906545,
0.0041970927,
-0.021225298,
0.013843744,
-0.015109533,
0.006565452,
0.0068685752,
0.0038806451,
0.010705917,
0.00590924,
0.008580723,
0.0061157634,
-0.016828343,
0.034083057,
0.014216819,
-0.02704793,
0.043356635,
-0.027221143,
0.0014406687,
-0.014256791,
-0.023836821,
-0.017454576,
-0.026181864,
0.0009110356,
0.0018270677,
-0.0028580201,
-0.0035475425,
-0.00847413,
-0.009759906,
-0.011212233,
-0.00078195834,
-0.017214742,
0.013710503,
-0.017054852,
0.001473979,
0.00038973003,
-0.022491086,
0.01986624,
0.0026115242,
-0.0017854299,
-0.0021901496,
0.000070732254,
-0.019626405,
0.02386347,
0.014829727,
0.010985724,
-0.04159785,
-0.007827911,
-0.025955353,
0.0050798147,
0.019812942,
-0.015149506,
-0.020532444,
-0.01776103,
0.011019033,
0.018267347,
-0.0075481045,
-0.0049732216,
0.0047000777,
0.03879979,
-0.0045601744,
0.008334227,
-0.006442204,
0.018054161,
-0.014283439,
0.001857047,
0.020772278,
-0.029552862,
0.014216819,
-0.021891503,
0.030112473,
0.019653052,
-0.02399671,
-0.009673299,
-0.017201418,
0.020199342,
-0.040185496,
-0.0026481657,
-0.03386987,
0.0014856375,
-0.018920228,
0.05382938,
0.0068685752,
-0.004600147,
-0.0075281183,
-0.018293994,
0.001986957,
0.0067653134,
-0.027021281,
0.0045135403,
-0.019373247,
-0.019586433,
0.0016155476,
0.00525969,
-0.004733388,
0.035895135,
0.026261808,
-0.036268212,
-0.032191034,
-0.0319512,
-0.04530195,
-0.006442204,
-0.0008569064,
0.036001727,
0.0026798104,
0.0215584,
-0.00412381,
0.013110918,
0.008434158,
0.029419621,
-0.057187054,
-0.021611696,
0.01308427,
-0.040611867,
0.024649592,
-0.00805442,
-0.04786018,
-0.004896608,
0.017387955,
-0.006555459,
-0.0032244332,
0.021238621,
-0.0016480251,
-0.010179616,
0.0026681519,
0.008527426,
-0.0031827954,
0.004340327,
0.00068952236,
-0.028646823,
0.02542239,
-0.009127011,
-0.00070867577,
0.0045401882,
0.0037007697,
0.022690948,
-0.0061024395,
-0.008141028,
-0.016735075,
-0.021158677,
0.008480792,
-0.015669147,
-0.009386831,
0.0054995236,
0.0035275565,
0.020958815,
-0.01798754,
0.0018753676,
-0.005659413,
0.014763107,
0.013557276,
-0.017587816,
0.013164215,
-0.0104261115,
-0.0033693328,
-0.0007344912,
-0.013697178,
0.0028063892,
0.004476899,
-0.0053529586,
-0.004873291,
-0.021198649,
-0.007821249,
0.022504412,
-0.014070254,
0.025342446,
-0.007814587,
-0.005392931,
0.005246366,
-0.008747274,
0.011278854,
-0.021838205,
0.0053363037,
0.017587816,
-0.011412094,
0.015509256,
0.010879131,
0.01107233,
-0.0036541354,
0.029632807,
0.20455164,
-0.007448174,
-0.013597248,
0.02646167,
0.0059125707,
-0.0019819604,
0.018387264,
0.018840283,
-0.01782765,
0.025568955,
0.01613549,
-0.011711887,
0.0017487886,
0.009146997,
0.013404048,
-0.02734106,
-0.025089286,
-0.0015880666,
-0.016388647,
0.0006861913,
0.003276064,
-0.0068685752,
0.00029937594,
0.008807233,
0.045328602,
0.012997663,
0.0009201959,
-0.0044502504,
0.03091192,
0.020412527,
0.0009759906,
-0.018760338,
0.0072216643,
0.0009318545,
-0.012764491,
-0.0008852201,
0.0116785765,
-0.009526734,
0.010805848,
-0.00021880676,
-0.0042337338,
-0.007341581,
-0.007201678,
0.006085784,
0.017601142,
0.017947568,
0.014669838,
-0.01812078,
-0.0008115212,
0.015775738,
-0.023903443,
-0.010312856,
0.010046374,
0.007228326,
-0.017481225,
-0.002035257,
0.026808096,
0.000023694523,
-0.017387955,
0.006285646,
0.009027081,
0.0036208252,
-0.010885793,
0.029019898,
-0.019439867,
0.025022667,
-0.015096209,
-0.006045812,
-0.017414603,
-0.020412527,
-0.0060991086,
0.009493424,
-0.0043203407,
0.020052776,
-0.011078992,
-0.006522149,
0.03762727,
0.02766084,
0.02688804,
0.021291917,
-0.004247058,
-0.00040471964,
-0.023463747,
-0.002947958,
-0.029526213,
-0.03757397,
0.018973524,
-0.0013324104,
-0.0087605985,
-0.013723827,
-0.0134906545,
0.0059858537,
-0.009679961,
-0.015948951,
0.025595604,
0.013317442,
0.0154026635,
0.0070018163,
-0.022611003,
-0.017721057,
-0.014056929,
0.06512822,
-0.025302473,
0.0039072935,
-0.0077612903,
-0.031604774,
-0.026368402,
0.015096209,
-0.011392108,
-0.009833189,
0.01841391,
-0.036214914,
0.015669147,
-0.014336736,
0.012937705,
0.0174679,
-0.006702024,
-0.014310087,
0.0024882765,
-0.020012803,
-0.0004780022,
-0.010672607,
-0.0027264447,
0.017214742,
-0.0089071635,
0.0030628783,
-0.006811948,
-0.015242775,
-0.004483561,
-0.018600449,
0.010645959,
-0.035602003,
0.012451375,
-0.0026081933,
-0.0059691984,
-0.008813894,
-0.010159629,
-0.0066187484,
-0.020026127,
-0.015136181,
0.026035298,
-0.010892455,
-0.0088605285,
0.01344402,
-0.012178231,
0.0025349108,
0.012971015,
0.028966602,
-0.010692593,
-0.0045368574,
-0.022424467,
-0.014776431,
-0.0037041008,
-0.0051764143,
0.049725555,
-0.004363644,
-0.013350752,
-0.01610884,
-0.004843312,
0.012451375,
-0.019146737,
-0.016641805,
0.037653916,
0.015309395,
0.021744937,
0.02691469,
-0.16916282,
0.01870704,
0.009560044,
-0.019786295,
0.018360615,
0.0051630903,
0.025515659,
0.014030281,
0.0055661444,
-0.0178543,
0.00010019101,
-0.0030279025,
-0.021891503,
-0.016775046,
0.010532704,
0.007588077,
-0.0483132,
0.029286379,
0.024942722,
0.02311732,
0.013550613,
0.01938657,
0.011325488,
0.0062423428,
0.014976293,
-0.009266914,
-0.03312372,
0.008407509,
-0.0031611435,
-0.01561585,
-0.005436234,
0.013077607,
0.014603217,
-0.0032494157,
-0.02103876,
-0.004217079,
0.0053762756,
-0.022557708,
-0.003970583,
-0.013217511,
0.030299012,
0.033949815,
-0.003737411,
0.014403356,
-0.007308271,
-0.0036508043,
0.027474301,
-0.012231527,
-0.0011583642,
-0.0052330415,
-0.021198649,
-0.012251513,
0.01828067,
-0.016122166,
-0.016548537,
-0.0025948691,
0.0023633628,
0.016388647,
0.01081251,
0.0066420655,
0.009400155,
-0.037254192,
0.0122648375,
0.009613341,
-0.007201678,
-0.014256791,
-0.0000058162836,
-0.0038839763,
-0.0050664903,
0.00672201,
-0.019879563,
-0.015415988,
0.012344782,
-0.007308271,
0.045648377,
0.022477763,
0.004976553,
0.005019856,
0.017587816,
-0.0044602435,
0.0036474734,
0.012444713,
-0.023690255,
0.00013365742,
-0.041198127,
0.012378092,
0.0000030398865,
0.019826267,
-0.007195016,
-0.014403356,
0.030405605,
-0.03906627,
0.0012399744,
-0.0065821074,
0.016028896,
0.027714135,
-0.017454576,
-0.018520504,
0.012631251,
-0.0092269415,
0.0013707172,
0.012844436,
-0.0058459505,
0.011085655,
0.00087356154,
-0.007994462,
-0.0047367187,
-0.017347982,
0.045701675,
-0.012244851,
-0.022784216,
-0.00043511525,
0.0011766849,
-0.009047067,
-0.0019786295,
0.042423945,
-0.003597508,
-0.0015905648,
0.0071283956,
-0.006302301,
0.037680566,
-0.023037376,
-0.002828041,
-0.00088438735,
0.0051897382,
0.007081761,
-0.114800476,
-0.012318133,
0.01970635,
0.009833189,
0.016468592,
0.023663608,
-0.00899377,
-0.0021701634,
-0.023517042,
0.061184283,
-0.0017104818,
-0.01740128,
-0.003211109,
-0.018760338,
0.028406989,
-0.010346167,
0.008940473,
-0.035575356,
-0.0085407505,
0.024542999,
-0.0031344953,
-0.026115242,
0.013543951,
-0.0035042393,
-0.010339504,
-0.019133413,
-0.0072616367,
0.0044036163,
0.0005075651,
0.022824189,
-0.0019003503,
-0.018453883,
-0.006921872,
-0.023890117,
-0.011452067,
-0.010472746,
-0.02071898,
0.008420833,
0.023290534,
-0.013790447,
0.009040404,
-0.0036441423,
-0.0074348496,
-0.017201418,
0.016388647,
-0.001224152,
-0.008121042,
0.029952586,
0.0015122858,
-0.0027614206,
-0.024716211,
-0.008167676,
-0.016481915,
0.0058659366,
-0.00056585803,
-0.0012341451,
0.024702888,
-0.022770893,
0.010019726,
0.0017837643,
-0.017387955,
0.0058759297,
-0.020852223,
0.032910537,
0.021531751,
0.0022284563,
-0.0051730834,
0.007101747,
-0.01331078,
-0.015309395,
-0.020225989,
0.020012803,
-0.013250821,
0.016415296,
-0.021545075,
-0.0215584,
-0.0044402573,
-0.012764491,
-0.0103794765,
-0.008314241,
0.0054828688,
-0.005492862,
0.010053036,
0.001511453,
0.025982002,
0.01223819,
0.005139773,
-0.024756184,
0.009000432,
-0.023530368,
0.004750043,
0.017068177,
-0.007834573,
-0.016668454,
0.010306194,
0.0029229752,
0.004120479,
-0.0076546976,
-0.019679701,
0.0024416419,
-0.006562121,
0.00050215214,
-0.04356982,
0.0013623897,
0.0057260334,
-0.016681777,
0.0063722525,
0.007328257,
0.04948572,
0.001980295,
-0.00951341,
-0.00080652465,
-0.026501643,
0.035308875,
-0.01870704,
-0.0057460195,
-0.03328361,
-0.009853175,
0.016068868,
0.022451114,
0.013790447,
0.0230507,
-0.016188785,
0.008900501,
0.010112994,
0.0027414344,
0.00199695,
0.005919233,
-0.01782765,
0.026448345,
-0.01931995,
-0.025595604,
0.012904394,
-0.0013865395,
-0.007854559,
0.021291917,
-0.0022750907,
-0.03834677,
0.011711887,
0.018360615,
0.03522893,
-0.003399312,
-0.032937184,
-0.029739399,
-0.00024941057,
-0.03645475,
-0.033683334,
0.012631251,
-0.038293473,
0.03328361,
-0.018520504,
0.011865114,
0.01103902,
0.010499394,
0.002896327,
-0.018853607,
-0.0045335265,
-0.007448174,
-0.013257483,
0.01311758,
0.015149506,
-0.012684546,
0.046021454,
-0.00033289441,
0.0027064586,
0.004107155,
0.0066720448,
-0.004843312,
-0.019759646,
-0.0020968807,
-0.016322026,
-0.01999948,
-0.0051930696,
-0.0036108322,
-0.02519588,
0.023450423,
0.013976985,
-0.008074407,
-0.010852482,
0.009833189,
-0.004003893,
0.043010205,
0.02678145,
0.012737843,
-0.0155492285,
0.028646823,
0.020012803,
0.008673991,
-0.02428984,
0.001873702,
0.0012074969,
0.014283439,
0.0023517043,
0.0031061817,
-0.014869699,
0.013230835,
0.00303623,
0.022690948,
0.0032344263,
0.017148122,
-0.0046034777,
0.03221768,
0.0072349883,
0.009533396,
-0.015908979,
-0.03464267,
-0.005815971,
-0.006568783,
-0.02370358,
-0.03315037,
0.0017154784,
0.019732997,
-0.00603915,
0.016601833,
-0.010279546,
-0.0029762716,
-0.011551998,
-0.013950337,
0.0010409456,
-0.007688008,
-0.020852223,
-0.004396954,
-0.00069035514,
0.013643882,
0.020305933,
-0.0057160403,
0.017214742,
0.00970661,
0.0049698907,
0.006698693,
-0.0028730098,
0.006612086,
-0.008747274,
0.0029179787,
-0.006848589,
-0.016575186,
0.0072882846,
-0.058679353,
-0.012544643,
0.009600016,
0.0037074317,
0.06486174,
0.009360183,
-0.0063389423,
0.02058574,
-0.0068419273,
0.01412355,
0.0027231136,
0.0029962577,
-0.00590924,
-0.037707213,
0.039306104,
-0.0066420655,
0.014296764,
-0.020692334,
0.0048266565,
0.0130243115,
-0.00316614,
0.0036174941,
0.006308963,
-0.0105260415,
0.013550613,
-0.013337428,
0.009613341,
-0.013050959,
-0.020225989,
-0.025155907,
0.0033726636,
0.0111389505,
-0.022637652,
-0.0012799466,
0.013450682,
0.00020600314,
-0.023983387,
0.007907855,
-0.0018220711,
-0.011212233,
-0.007494808,
-0.012744505,
-0.01941322,
0.0004132554,
-0.008007786,
0.009466776,
-0.012897733,
-0.010439435,
-0.032004498,
-0.015495933,
0.009340197,
-0.003990569,
-0.04714068
] |
Mouse embryos undergo genome-wide methylation reprogramming by demethylation in early preimplantation development, followed by remethylation thereafter. Here we show that genome-wide reprogramming is conserved in several mammalian species and ask whether it also occurs in embryos cloned with the use of highly methylated somatic donor nuclei. Normal bovine, rat, and pig zygotes showed a demethylated paternal genome, suggesting active demethylation. In bovine embryos methylation was further reduced during cleavage up to the eight-cell stage, and this reduction in methylation was followed by de novo methylation by the 16-cell stage | [
-0.023023967,
-0.030663973,
-0.003956432,
-0.028169278,
-0.03430207,
0.030560028,
-0.019905597,
-0.0022591942,
-0.05457148,
-0.009329124,
-0.0049699023,
0.004482657,
0.019203963,
-0.018840153,
-0.01151848,
0.013097155,
0.026662065,
-0.012629399,
-0.0044631674,
0.010673922,
-0.02822125,
0.012889263,
0.012012222,
-0.011278105,
-0.005570838,
0.0112261325,
0.009666948,
-0.026467167,
-0.022816075,
-0.0068084416,
-0.000027813589,
0.016852193,
-0.011161166,
-0.011726371,
-0.021841584,
-0.012746338,
0.012843787,
-0.007665993,
-0.00042390343,
-0.011908276,
0.0033522479,
0.020828115,
-0.015176068,
0.0017833179,
-0.015513891,
-0.0069383737,
-0.0039824187,
-0.003975922,
-0.0054279133,
-0.0013553541,
0.023621654,
0.016670287,
-0.0034529453,
0.020503284,
-0.033028737,
0.0071137818,
-0.015838722,
0.021321855,
0.009082253,
-0.0060873185,
0.006512846,
0.0006918884,
-0.030248191,
0.018125527,
-0.004300752,
-0.00016809964,
-0.00075360615,
-0.010946779,
0.016202532,
-0.009653954,
0.048516642,
0.011765351,
0.005856689,
-0.02437526,
0.024583152,
0.00091196084,
-0.03263894,
-0.0018158009,
0.0075945305,
0.0134089915,
0.038200036,
-0.016566342,
-0.009894329,
0.042747658,
-0.0074645984,
0.019632738,
0.011797834,
-0.0012432877,
0.013246576,
0.002298174,
0.017501853,
0.03489976,
0.015838722,
0.018203486,
-0.011031235,
-0.0018937602,
0.0073151765,
0.01708607,
0.008478069,
-0.012999706,
-0.015150081,
0.00466781,
0.006048339,
-0.013383006,
-0.046021946,
0.0031199944,
0.02397247,
-0.0006265163,
0.013746815,
-0.006301706,
-0.002481703,
0.024557166,
0.009322627,
-0.05101134,
0.026415193,
0.005996366,
0.018203486,
0.00033376305,
-0.0105894655,
0.010888309,
0.0181775,
0.017501853,
0.018320424,
-0.04412494,
0.026012404,
0.031469554,
-0.02299798,
0.0066102953,
-0.0027756742,
-0.0016631307,
0.025999412,
-0.01566981,
0.010180179,
0.029520571,
-0.03344452,
0.0133180395,
0.0012554688,
-0.0033717377,
-0.013980693,
-0.030534042,
0.0028016607,
0.021854578,
-0.016943144,
0.00947205,
-0.01668328,
0.014916204,
-0.004622334,
-0.00034533514,
0.0216207,
-0.010914296,
-0.014279537,
-0.006587557,
0.03133962,
-0.006265975,
0.012291576,
0.032223158,
0.0065160943,
0.0195158,
-0.03591323,
0.0001053668,
0.0025288032,
0.0029998072,
-0.00008643529,
0.01643641,
0.0174109,
0.024440227,
0.013447971,
-0.003729051,
0.00044867175,
-0.039915137,
-0.021282876,
0.0065225908,
-0.034717854,
0.016332464,
-0.019268928,
0.020815121,
-0.011336575,
0.0049146814,
-0.020919066,
-0.017021105,
-0.021282876,
0.019216957,
0.018320424,
0.015474912,
-0.016930152,
0.004278014,
0.002074041,
-0.03700466,
0.004544375,
-0.017397907,
0.004213048,
0.004563865,
-0.0004243095,
0.0015502522,
-0.6452947,
-0.02049029,
0.024596145,
-0.0019733435,
0.0075815376,
0.0250639,
0.009485043,
-0.0068539176,
-0.016228518,
0.009166709,
-0.010875316,
0.009634464,
0.026740024,
-0.028091317,
-0.01253195,
-0.021919543,
-0.0044339327,
-0.0014373737,
0.019619746,
0.0020610478,
-0.027363699,
-0.020022536,
-0.0061652777,
0.0075815376,
0.018528316,
0.00505111,
-0.00049902045,
0.0068409247,
-0.001482038,
0.04085065,
-0.029052814,
0.009329124,
-0.028403156,
0.007555551,
0.04404698,
0.011304092,
0.011122187,
0.029052814,
0.00041903098,
0.0411365,
-0.00025499173,
0.011849807,
0.021010019,
0.01502015,
-0.0152280405,
0.019242942,
0.004622334,
-0.0019928333,
-0.001299321,
0.008822389,
-0.013993686,
0.020087501,
-0.0285071,
0.010823343,
-0.010160689,
0.013681849,
0.027337711,
-0.009920315,
0.029988326,
0.0058534406,
-0.006691503,
0.0076270136,
0.008945825,
-0.009783886,
-0.004050633,
0.0010353964,
-0.002298174,
0.0012059322,
-0.01142103,
-0.011505486,
0.006769462,
0.014305523,
0.0035406495,
-0.004144834,
-0.00287962,
0.032379076,
-0.0070553124,
-0.00023245663,
-0.0038752246,
0.015968654,
-0.015604844,
-0.002923472,
-0.0060905665,
0.0043169935,
0.03113173,
-0.009835859,
0.0033067716,
0.0141366115,
-0.01157695,
-0.009712424,
0.006509598,
0.0029413376,
-0.008750927,
-0.02822125,
-0.01858029,
0.014240557,
-0.0021633692,
0.017670764,
0.0031102493,
-0.013577904,
-0.033626426,
-0.00045922873,
0.010316608,
0.0115899425,
0.026999889,
-0.006564819,
-0.063095026,
0.010479023,
0.039577316,
-0.008971811,
-0.0056585427,
0.0056195627,
0.011323581,
-0.0066785095,
-0.0047002933,
-0.026895942,
-0.010160689,
0.008783409,
-0.0071722516,
-0.027935399,
0.011148173,
-0.018645255,
0.0006139291,
0.0031005044,
0.014786272,
0.009277151,
-0.010901302,
-0.0005282551,
0.015254027,
-0.0109532755,
-0.010290622,
0.007821912,
0.008198715,
-0.02251723,
0.014266543,
0.011219636,
0.0030647733,
-0.0022072215,
0.0051518073,
0.008536538,
-0.01907403,
0.0029153512,
-0.0012692742,
-0.011050724,
0.007276197,
-0.020347366,
-0.023062946,
0.008237694,
0.008932831,
-0.010634942,
0.021139951,
0.016332464,
0.010154193,
0.0023582675,
0.021854578,
0.0049049365,
-0.015734777,
-0.026363222,
0.0072177276,
-0.017332941,
0.0009574371,
0.025934445,
-0.017943623,
-0.0045833546,
0.0016517617,
-0.0134089915,
-0.01502015,
-0.0057852264,
-0.03284683,
-0.020386346,
0.014708312,
0.00015997888,
-0.0044306843,
0.0073021837,
-0.0024703338,
0.017696751,
-0.0060970634,
-0.020906074,
-0.031443566,
0.006996843,
0.010738887,
-0.015825728,
-0.002588897,
-0.0029575792,
0.046619635,
-0.00038309666,
0.012629399,
-0.005119324,
0.0032970267,
0.029494584,
0.0025271792,
0.028481115,
0.00032868757,
0.000102270766,
0.015526885,
-0.038641803,
0.005197284,
0.009744907,
0.010050247,
0.025882473,
0.02433628,
-0.01752784,
-0.016592328,
-0.012525453,
0.025687573,
-0.031547513,
-0.0018547806,
-0.033912275,
-0.02052927,
0.00097286655,
-0.0037258028,
0.0071527613,
-0.0020772894,
-0.0049504125,
0.0010906175,
-0.018723214,
-0.02234832,
-0.009101743,
-0.003189833,
0.014071645,
-0.0034854284,
-0.0018255459,
0.013837768,
-0.005512369,
0.001127973,
0.028481115,
-0.016917158,
0.0064089005,
0.012479978,
-0.0058436957,
-0.005934648,
0.02996234,
-0.019320901,
-0.010024261,
0.016631307,
0.025271792,
0.014942191,
-0.013733822,
0.028792951,
0.019061038,
-0.0054798857,
0.02279009,
0.018151512,
-0.0135908965,
0.005288236,
0.0044306843,
0.017787702,
0.029546557,
-0.00419031,
0.008569022,
-0.010024261,
0.011304092,
-0.018801173,
0.008120756,
0.009114736,
-0.015046136,
-0.019905597,
-0.0058371993,
0.019320901,
0.024635125,
-0.0038070101,
0.00436247,
-0.024635125,
-0.025856486,
0.0153189935,
-0.0070423195,
0.016462395,
-0.004118847,
0.0055058724,
-0.011434024,
-0.031157715,
0.010453037,
-0.0042390344,
-0.004511892,
0.014877224,
0.0029218479,
-0.008107763,
0.011745861,
0.033184655,
0.019827638,
-0.0149551835,
-0.018736208,
0.030612001,
0.026272269,
-0.015578858,
0.0048724534,
-0.022413285,
-0.034561936,
-0.0069578635,
-0.0005176982,
0.009920315,
0.02020444,
-0.0055188653,
0.007555551,
-0.025154853,
-0.033184655,
0.0067304824,
-0.0014276288,
0.009010791,
-0.0035796291,
0.012921747,
0.0015973527,
-0.015033143,
-0.0019246191,
0.02615533,
-0.0013878371,
0.008614497,
-0.023712607,
-0.00083806197,
-0.0034561935,
-0.017358927,
-0.021178931,
0.0046710586,
-0.014201578,
-0.036121123,
-0.010518002,
-0.007256707,
0.016176546,
0.015422939,
-0.0006265163,
-0.039057586,
-0.020802127,
-0.015656818,
-0.0018239217,
0.027389685,
0.051297188,
-0.010556982,
0.02202349,
0.023556689,
0.002912103,
-0.010017764,
-0.026610091,
0.025089886,
-0.0145004215,
-0.01752784,
0.003933694,
0.012973719,
-0.011550963,
0.016579336,
0.020503284,
0.0035601393,
-0.023751587,
-0.019177977,
0.0040019085,
-0.0059249033,
-0.006691503,
0.031495538,
0.025258798,
0.026467167,
-0.0067239855,
0.036043163,
0.019489814,
0.0020610478,
-0.025167845,
-0.016306477,
0.018853147,
0.0044566705,
0.023920497,
0.020750156,
-0.015812736,
0.0036348503,
0.0026457421,
0.0145004215,
-0.002437851,
0.019580767,
0.025037915,
0.003094008,
0.0074970815,
0.013090658,
-0.009563002,
-0.0039142044,
-0.006441383,
-0.010401064,
-0.031157715,
0.016514368,
-0.022322332,
-0.0137728015,
-0.0077049728,
0.0049763992,
0.036329012,
-0.009095246,
-0.025986418,
-0.008348137,
-0.01538396,
-0.0060191043,
-0.0108623225,
-0.009056266,
-0.0094070835,
-0.02712982,
-0.009082253,
-0.00010790454,
-0.002536924,
-0.033938263,
-0.0051063313,
0.0064186454,
-0.019268928,
-0.04506045,
-0.024349274,
0.020464305,
0.026272269,
-0.0059768762,
-0.019294916,
0.0047132866,
0.031885333,
0.0045313817,
-0.020672195,
0.01079086,
-0.021763625,
-0.001375656,
-0.0009200816,
-0.0033652412,
-0.01643641,
-0.029858394,
-0.010011268,
0.017358927,
-0.005408423,
0.010297118,
-0.0059606344,
-0.0032759127,
0.0075295647,
0.015189061,
0.02542771,
-0.0040376396,
-0.0068604145,
0.009400587,
-0.012941237,
-0.02247825,
-0.029078802,
-0.027883427,
-0.0146823265,
-0.007029326,
-0.0064446316,
-0.03126166,
0.00087541743,
-0.0051745456,
-0.02299798,
0.0062919613,
0.01680022,
0.047555145,
0.017982602,
-0.00024098343,
0.019294916,
0.014877224,
0.020789135,
0.025687573,
-0.027753495,
0.034509964,
0.019229949,
-0.017540833,
0.008692456,
-0.002299798,
0.0032742887,
-0.021763625,
0.0100437505,
0.006321196,
0.035289556,
-0.003946687,
-0.026103357,
-0.007484088,
-0.005856689,
0.02052927,
0.020269407,
0.0031232426,
0.0041123508,
0.0047587627,
0.01643641,
0.0053759404,
-0.021373829,
0.021763625,
-0.042357862,
0.0107778665,
0.024128389,
0.0005428725,
0.0001310487,
0.013616883,
-0.006970857,
-0.010634942,
-0.02198451,
-0.011856304,
-0.02822125,
0.0072372174,
-0.018424371,
0.04550222,
0.032119215,
0.041318405,
0.0045053954,
0.014734299,
0.019320901,
0.013863754,
-0.008458579,
-0.007880381,
0.025934445,
-0.02169866,
0.014422462,
-0.0028308954,
0.0006159593,
0.0028552576,
-0.0035536427,
0.019126004,
0.01773573,
-0.018931106,
-0.017280968,
0.013383006,
-0.03292479,
-0.031365607,
-0.0015177692,
0.00084374653,
0.0095954845,
-0.03567935,
-0.017566819,
0.016163552,
-0.004450174,
0.010453037,
0.005129069,
0.014877224,
-0.013538924,
0.022361312,
-0.007880381,
0.015604844,
-0.002460589,
-0.011330078,
-0.013811781,
0.0014162598,
0.0038329966,
-0.0020659203,
0.026259275,
0.013447971,
-0.00834164,
0.00832215,
0.026714038,
-0.036458943,
-0.003621857,
-0.0030566524,
-0.01429253,
-0.02473907,
-0.024726076,
-0.0027886676,
-0.023348797,
-0.007854395,
0.0066979993,
-0.0132270865,
0.010784363,
-0.006970857,
-0.023023967,
-0.0028130298,
-0.012005725,
0.034198128,
-0.017657772,
0.014578381,
0.028377168,
-0.0074970815,
-0.036043163,
-0.014396476,
0.0014333134,
0.018762194,
0.050517596,
0.007945348,
0.006892897,
-0.02923472,
0.007906368,
-0.0009988529,
-0.023062946,
-0.040954594,
0.0018417874,
-0.021789612,
-0.021113964,
0.0022494493,
-0.0059249033,
-0.017579813,
0.005119324,
-0.035653364,
0.01980165,
-0.0077569457,
-0.021711653,
-0.024427233,
0.014994163,
0.0052362634,
0.011700384,
-0.0013188107,
-0.00071868685,
0.010505009,
-0.009004294,
-0.015643824,
0.02056825,
-0.002804909,
0.035445474,
-0.017566819,
-0.011979738,
-0.0034789317,
0.0033619928,
-0.015189061,
-0.018060561,
0.0021130205,
0.037992142,
-0.019853624,
0.003621857,
0.017904641,
0.01976267,
0.013486951,
0.020750156,
-0.0082311975,
-0.024648117,
-0.0142275635,
-0.0030355384,
0.020659203,
0.012505963,
-0.00021296681,
-0.005310974,
-0.021776618,
0.026571112,
-0.03866779,
-0.033756357,
-0.0007438612,
-0.03887568,
0.018957091,
0.021971516,
0.027389685,
0.010193173,
0.011524976,
0.017384913,
-0.0017963111,
0.03113173,
0.0029754448,
0.028039346,
0.008893851,
-0.003537401,
-0.03474384,
-0.0029267203,
-0.026142336,
-0.025271792,
-0.015643824,
-0.022959,
-0.035003707,
0.013551917,
0.012921747,
0.016605321,
-0.0008729812,
-0.01498117,
0.0051420624,
0.023478728,
0.020230426,
-0.016670287,
-0.003858983,
0.0015867957,
-0.019866617,
-0.005502624,
0.017826682,
-0.0042195446,
-0.022075461,
-0.014643347,
-0.021997502,
0.025180839,
-0.03323663,
-0.005642301,
0.007802422,
0.010206166,
0.009296641,
-0.000644382,
-0.017021105,
-0.017501853,
-0.015604844,
0.0064024036,
-0.0041253436,
-0.0139547065,
-0.015396953,
0.022179408,
-0.0052492563,
0.006931877,
-0.0119537525,
-0.009926812,
-0.0030777664,
-0.038174048,
-0.0533761,
0.0060710767,
-0.03716058,
0.027987372,
0.032690912,
-0.0047230315,
-0.014942191,
0.010543989,
-0.032301117,
-0.026947916,
0.012194127,
-0.0008238507,
0.013097155,
0.00088028994,
0.016189538,
-0.016826205,
-0.004287759,
0.026714038,
0.0038849695,
-0.00971892,
0.010842833,
0.008978307,
0.021880563,
0.017982602,
-0.012798311,
-0.0062204986,
0.004417691,
-0.010219159,
-0.0033587446,
0.009621471,
-0.0076270136,
0.025492676,
-0.005362947,
0.021087978,
0.020412331,
0.020282399,
0.037628334,
-0.01142103,
-0.00908875,
0.018931106,
-0.014474435,
-0.029442612,
-0.006899394,
0.0035536427,
-0.015280014,
0.00086973293,
-0.040149014,
0.011628922,
0.013759809,
0.0013017572,
0.022452265,
0.00019357851,
-0.006821435,
-0.005408423,
0.0015786749,
-0.012869773,
-0.023920497,
-0.01388974,
-0.011018241,
0.00625623,
-0.0032856576,
-0.0074191224,
0.0064966045,
-0.0017508349,
0.0048951916,
-0.023946485,
-0.00093226274,
-0.008809396,
-0.0017345934,
-0.02020444,
0.0181775,
-0.0051842905,
0.0036283536,
-0.0037777754,
-0.010595962,
-0.007938851,
-0.006353679,
0.011583446,
-0.022049475,
-0.00085592765,
0.0056780325,
0.01287627,
-0.011369058,
-0.0041155987,
0.000935511,
-0.013006202,
-0.0058729304,
0.02655812,
0.19396262,
-0.015487906,
-0.010751881,
0.02996234,
-0.009705927,
-0.032690912,
0.028091317,
0.004684052,
-0.012492971,
-0.024427233,
0.021074984,
0.008270178,
-0.025284784,
0.002408616,
0.03700466,
-0.016878178,
-0.018840153,
-0.00054409064,
-0.01044654,
-0.016267497,
0.017332941,
-0.031755403,
-0.0030793906,
0.0028016607,
0.014526407,
0.0052817394,
-0.042097997,
0.026869956,
0.0049081845,
0.008757423,
-0.027571589,
0.009926812,
0.010388071,
-0.008536538,
0.0072956868,
-0.011960248,
0.00017287058,
-0.018151512,
-0.011752358,
-0.0074451086,
-0.014812258,
0.019022059,
0.010985758,
-0.0013878371,
-0.0030907595,
0.029026829,
0.0026392455,
-0.004092861,
0.002847137,
-0.011908276,
-0.021646686,
0.017969608,
-0.0062952098,
0.021023013,
-0.005103083,
-0.021113964,
0.010206166,
-0.009251165,
0.0028714992,
0.039161533,
-0.024063423,
0.006353679,
-0.019268928,
0.0107713705,
-0.021425802,
0.013331032,
-0.009121233,
0.006577812,
0.015124096,
-0.018476343,
-0.005596825,
-0.0096799405,
-0.01352593,
-0.008880858,
0.0026944666,
-0.027155807,
0.03729051,
0.027597576,
0.02777948,
0.019164983,
-0.0022153421,
-0.015280014,
-0.020659203,
0.002428106,
-0.002043182,
-0.023478728,
0.0600806,
0.008523545,
-0.012505963,
0.005138814,
0.0049828957,
-0.025856486,
-0.0174109,
-0.0003589374,
0.013473958,
-0.022465259,
-0.00081085745,
0.024206348,
-0.008750927,
-0.0035763807,
-0.03412017,
0.05332413,
0.0017199761,
0.017228995,
0.005187539,
0.01153797,
0.0027350704,
0.018047567,
-0.0113170855,
0.0046450724,
-0.0001753068,
-0.011330078,
0.017099064,
0.006912387,
-0.0065388326,
0.032976765,
0.005954138,
-0.04607392,
0.027103834,
0.0011044227,
-0.0036803265,
-0.025310772,
0.014695319,
0.010186676,
-0.01871022,
-0.008146742,
-0.025076894,
0.015254027,
-0.017203009,
-0.0142275635,
-0.0072697005,
-0.0029380894,
0.0113170855,
0.004031143,
-0.014461442,
-0.028766965,
0.007821912,
0.0016680032,
-0.020685188,
0.005447403,
-0.008952321,
0.011291099,
-0.00071178423,
-0.005788475,
-0.0077114697,
-0.034587923,
0.013681849,
0.024881994,
-0.029832408,
-0.007542558,
-0.027363699,
-0.0070877955,
0.015396953,
-0.017540833,
0.027311726,
-0.020737162,
-0.008328647,
-0.04584004,
-0.023595668,
0.013993686,
-0.034613907,
0.0007763442,
-0.002150376,
-0.02158172,
-0.0105894655,
-0.0045053954,
-0.16225919,
-0.021958522,
0.021854578,
-0.026181316,
0.021503761,
0.011745861,
0.007458102,
-0.011524976,
-0.011265112,
-0.004216296,
0.024323286,
0.007094292,
-0.03570534,
-0.0078608915,
0.013344025,
0.022088455,
-0.017501853,
0.034717854,
0.010576472,
0.004398201,
0.016657295,
-0.028299209,
0.017943623,
0.0034269588,
0.013460965,
0.022010496,
0.021282876,
-0.009647458,
0.0033587446,
-0.039343435,
-0.019905597,
0.0028666267,
0.009465553,
0.0036705816,
0.016475389,
-0.0032872818,
0.0032385574,
-0.0017508349,
-0.0008997797,
0.014734299,
0.009926812,
0.012239603,
-0.0099527985,
-0.006623288,
0.004953661,
0.019814644,
-0.0064738663,
-0.021802604,
0.037056632,
0.0041935584,
0.0055286107,
0.010569976,
0.0033457514,
0.0015096485,
0.035237584,
0.0077634426,
0.022465259,
0.0062789684,
-0.010323104,
-0.01081035,
0.0070358226,
-0.011745861,
0.033860303,
0.017203009,
0.014331509,
-0.028117305,
-0.0013918976,
0.018684234,
-0.036666837,
-0.025622608,
-0.005928152,
-0.0074516055,
0.0010776243,
-0.025297778,
0.020113487,
0.006769462,
0.0024459716,
0.012557937,
0.01809954,
-0.0070098364,
-0.037550375,
0.0285071,
-0.021633692,
-0.012122664,
-0.015072122,
0.014305523,
0.007867388,
0.008218205,
-0.0033457514,
0.013668856,
0.015877701,
-0.019190969,
0.014539401,
-0.004200055,
0.030612001,
0.014396476,
-0.020087501,
-0.028481115,
0.0016533858,
-0.013486951,
0.0011182281,
-0.012642392,
-0.016540356,
0.011297596,
0.03352248,
-0.0035081664,
-0.009744907,
0.015046136,
0.03432806,
-0.015461919,
-0.013759809,
0.0070033395,
-0.014604367,
0.019229949,
0.0057007703,
0.03583527,
0.0018434115,
0.013051678,
-0.003267792,
-0.0033051476,
0.06506999,
-0.002299798,
0.011271609,
0.020217434,
-0.010037254,
0.001257905,
-0.13637672,
-0.022049475,
-0.019087024,
0.017878655,
-0.0074191224,
0.022127435,
0.0063471827,
0.037602346,
-0.01364287,
0.017501853,
-0.024804035,
-0.025765533,
-0.006545329,
-0.0045151403,
0.009614974,
0.0050251237,
-0.016813213,
0.011245622,
-0.006996843,
0.049244262,
0.0059411447,
0.00040888003,
0.009270655,
-0.018190492,
0.011239125,
0.013331032,
-0.028533086,
0.019697705,
0.009621471,
0.008646981,
0.007932354,
-0.022868048,
0.007737456,
-0.010842833,
-0.036121123,
-0.0023939987,
-0.011914773,
-0.02822125,
0.025375737,
0.0058534406,
-0.010634942,
-0.0020285647,
-0.009913819,
-0.013863754,
0.008582015,
-0.0022429528,
-0.017060084,
0.00208541,
-0.02648016,
-0.014110625,
-0.031001797,
0.0043884562,
0.0037777754,
-0.00042633968,
0.011667902,
-0.015890695,
0.017073076,
-0.010323104,
-0.028091317,
0.011037731,
0.014695319,
-0.003962929,
-0.0041123508,
0.0014958432,
0.016111579,
-0.023413762,
-0.025089886,
-0.026467167,
0.021789612,
-0.015578858,
-0.0075945305,
0.020386346,
0.0007012272,
-0.02648016,
-0.030508054,
-0.0061425394,
-0.008913341,
0.0041415854,
0.010803853,
-0.024933968,
-0.003472435,
-0.009309635,
0.031963293,
0.001871022,
0.020906074,
0.027155807,
0.010816846,
-0.001922995,
-0.00466781,
-0.008146742,
-0.022114443,
0.035653364,
-0.023699613,
-0.042955548,
-0.007360653,
-0.00056155026,
-0.022725122,
0.011323581,
0.028039346,
0.012220114,
-0.009783886,
-0.016124573,
-0.046593647,
0.010699907,
-0.007425619,
-0.018034574,
0.0085885115,
-0.012817801,
0.016579336,
0.006425142,
0.00013876341,
0.026493153,
-0.020737162,
0.0113170855,
-0.035159625,
-0.022231381,
-0.032976765,
0.008880858,
0.02967649,
-0.0054181684,
0.014149604,
0.0285071,
-0.007198238,
-0.009511029,
0.012668379,
0.0069578635,
0.0005416544,
-0.009900825,
-0.01821648,
0.0048854467,
-0.0015137088,
-0.00061311707,
0.0071137818,
-0.03170343,
0.00019307097,
0.0153189935,
0.0008973435,
-0.00073208613,
0.0030534042,
0.005265498,
0.04048684,
0.029754449,
-0.013720829,
-0.010316608,
0.0017151036,
-0.003943439,
0.021243896,
0.008737933,
-0.012622902,
-0.0022299595,
-0.006136043,
-0.018125527,
0.033262614,
0.010803853,
0.0015064002,
-0.008491062,
-0.026337234,
-0.011836814,
-0.011395045,
0.016293485,
-0.019372875,
-0.0033457514,
0.015877701,
0.012882766,
0.019307908,
-0.010556982,
-0.0019278674,
0.0038005137,
-0.024933968,
0.0034659386,
-0.009030281,
-0.019957568,
-0.034068193,
0.008536538,
0.015968654,
0.0055513484,
-0.024804035,
-0.008958817,
-0.020438317,
0.01465634,
-0.020074507,
0.025284784,
0.0033181407,
-0.011511983,
-0.01813852,
0.014734299,
0.037264522,
-0.0030972562,
-0.009965791,
-0.00036035854,
-0.014188584,
0.018398384,
-0.0001525687,
0.02242628,
0.026402202,
0.017241988,
-0.011836814,
0.010537492,
0.015046136,
0.008828886,
0.019489814,
0.019424848,
0.005470141,
0.019593759,
0.030715946,
-0.026999889,
-0.01737192,
0.036355,
-0.021126958,
-0.028195264,
-0.0013098778,
0.017060084,
0.014864231,
0.010115213,
-0.014851238,
0.004255276,
-0.0017021104,
0.026973901,
-0.003612112,
-0.03502969,
-0.025323763,
0.042279903,
0.0067499722,
0.004989392,
0.0014089511,
-0.0111351805,
0.020451311,
-0.006178271,
0.028766965,
-0.027259752,
-0.00009643397,
-0.0020155716,
0.02822125,
-0.0004929299,
-0.01834641,
-0.006652523,
-0.00011582228,
-0.024596145,
-0.0012830794,
0.003943439,
0.004771756,
0.08289667,
-0.0033295099,
-0.010920792,
0.0076140203,
-0.0016062855,
0.037264522,
0.0265971,
0.021815598,
0.006762965,
0.0037582857,
0.027519617,
-0.056754336,
0.02437526,
-0.0056910254,
-0.009030281,
0.013090658,
-0.030741932,
0.003116746,
-0.018125527,
-0.018918112,
0.024881994,
-0.022257367,
0.010654432,
0.02996234,
-0.018957091,
0.009575995,
0.025739547,
-0.022569204,
0.008731437,
0.031599484,
0.014279537,
-0.0012246099,
-0.03708262,
-0.00032746946,
-0.00016393776,
-0.0042975037,
0.014799265,
-0.02510288,
0.016176546,
0.000010271487,
-0.0050121304,
-0.021399815,
-0.007919361,
-0.016085593,
0.019463828,
-0.0054961275,
-0.0044371807,
-0.007640007,
-0.0016030371
] |
Vitamins are compounds that are essential for the normal growth, reproduction and functioning of the human body. Of the 13 known vitamins, vitamins A, D, E and K are lipophilic compounds and are therefore called fat-soluble vitamins. Because of their lipophilicity, fat-soluble vitamins are solubilized and transported by intracellular carrier proteins to exert their actions and to be metabolized properly. Vitamin A and its derivatives, collectively called retinoids, are solubilized by intracellular retinoid-binding proteins such as cellular retinol-binding protein (CRBP), cellular retinoic acid | [
-0.003333862,
-0.0029857862,
-0.010640256,
-0.021983052,
-0.018432042,
0.023145432,
-0.00020996305,
-0.019377274,
-0.011444982,
-0.01626056,
0.033721823,
0.01168129,
-0.029557688,
0.018227667,
-0.033849556,
-0.003452016,
0.034743696,
-0.00869231,
0.0031215039,
-0.009190474,
-0.012977792,
0.006290908,
0.009113833,
-0.0014002859,
0.000055734014,
-0.007057313,
0.019786023,
-0.054823507,
0.005716104,
-0.030732842,
-0.000052540658,
-0.016630989,
-0.016835364,
-0.011834571,
0.013744197,
0.01940282,
-0.010863791,
-0.04414493,
-0.010787151,
-0.0011799444,
0.033926196,
0.0056107235,
0.013539822,
-0.0057001375,
-0.013616463,
0.012556269,
-0.007408582,
-0.012160293,
-0.028382532,
0.03397729,
0.021088911,
0.013348221,
0.012383828,
-0.021025045,
0.005454249,
0.001634199,
-0.01521314,
0.012556269,
-0.011355568,
-0.026185505,
-0.011036232,
0.0005185209,
-0.006904032,
-0.0021922376,
-0.015864585,
0.013169393,
0.006967899,
0.013616463,
-0.0064633493,
0.03607213,
0.024831522,
0.02638988,
-0.0097333435,
0.020833444,
0.012549883,
-0.013488729,
-0.034105025,
0.0008550206,
0.0036659706,
0.0055628233,
0.024588829,
-0.0043685087,
-0.0203736,
0.0066038566,
-0.0023439222,
-0.003515883,
0.016324427,
0.025802303,
-0.007855652,
-0.033236433,
-0.0191729,
0.008200534,
0.0076832105,
0.006048213,
-0.012051719,
0.022034144,
0.015481382,
0.036276504,
-0.010608323,
0.0031087303,
0.00067619275,
-0.005923672,
-0.019900983,
-0.009580063,
-0.018815244,
0.020526882,
-0.018738603,
0.00024089866,
0.013603689,
-0.0056618173,
-0.012652069,
0.03867791,
0.019096259,
-0.052422103,
0.02478043,
0.00756825,
0.029583234,
-0.016043412,
-0.006904032,
0.0012390214,
-0.0011807428,
0.03114159,
0.022941057,
0.0046654907,
0.028203705,
-0.0011839361,
0.008775338,
-0.01954333,
-0.014255133,
-0.0025323299,
0.018112706,
0.0015735254,
-0.027181832,
0.0036723574,
-0.018853564,
0.008570963,
-0.0282548,
0.025725663,
0.012428535,
0.0023231653,
0.010851018,
0.0021794643,
-0.021446567,
0.008794498,
0.0017914717,
0.01569853,
0.009018033,
0.041104857,
-0.020143678,
-0.0025083798,
0.026338786,
0.005795938,
0.043199696,
-0.020475788,
-0.0013731424,
0.011668516,
-0.0075235427,
0.002798975,
-0.013961345,
-0.015353647,
0.018738603,
-0.021663716,
0.00053448766,
0.007957839,
0.020731255,
0.020577975,
0.020245867,
0.00019579254,
-0.0020804703,
0.008277174,
0.013169393,
0.004981633,
-0.029046752,
0.0071275667,
-0.013961345,
0.025393553,
0.005425509,
0.0044579227,
-0.026977457,
0.0043206085,
0.002937886,
0.0079769995,
0.03098831,
-0.0010122933,
0.0046463306,
0.008251628,
0.03783486,
-0.0042599346,
0.019875437,
-0.01884079,
0.0014417995,
0.0028165386,
0.006840165,
-0.027973784,
-0.6515465,
-0.006003506,
0.012613749,
-0.018930204,
0.015826264,
0.029736515,
0.0109212715,
0.0076576634,
0.00063907006,
0.017371848,
-0.0013515872,
-0.003784125,
-0.013897478,
-0.023656368,
0.0067379777,
-0.03502471,
-0.027284019,
-0.03180581,
0.0038671521,
-0.0068018446,
-0.023260392,
-0.016209466,
-0.0150470855,
0.012575429,
0.022200199,
0.02250676,
0.028024878,
-0.005409542,
0.011017072,
0.03867791,
-0.027565034,
0.038958922,
0.0062845214,
0.02235348,
0.043071963,
-0.0015623486,
-0.0034360492,
-0.0031215039,
0.027539488,
0.02456328,
-0.013693104,
-0.005278615,
0.022021372,
0.011464142,
-0.007472449,
0.012345508,
0.015928451,
0.018853564,
-0.0026632575,
0.016541576,
0.010748831,
-0.0058470317,
-0.03809033,
-0.019645516,
0.006048213,
0.0060258596,
0.0024748496,
-0.023771329,
0.008258014,
0.01315662,
-0.010410335,
0.00704454,
-0.020718483,
-0.012575429,
-0.018355401,
0.033389714,
-0.028382532,
0.03535682,
-0.0043748952,
0.0011384308,
-0.0015479785,
0.023618048,
0.025546834,
-0.018687509,
0.022366254,
-0.0053935754,
0.028356986,
0.012434921,
-0.0037553846,
0.027130738,
0.008737017,
-0.0064346087,
-0.0063420017,
-0.018623643,
0.028024878,
0.011949532,
-0.026645347,
0.011246994,
0.011777091,
-0.011866504,
0.014753297,
-0.009196861,
0.010263441,
-0.05206445,
-0.024231173,
0.010736058,
-0.0111192595,
0.0018760957,
-0.01872583,
0.006833778,
-0.017205793,
-0.006661337,
-0.0053137415,
0.017946651,
0.016758723,
-0.011815411,
-0.02425672,
0.009912171,
0.02646652,
-0.055641007,
0.007370262,
-0.02613441,
0.00059196807,
0.018253213,
0.00046982226,
-0.0121092,
0.01323326,
0.004215228,
0.0010953206,
-0.028127065,
0.035561193,
-0.0013523855,
0.007491609,
0.016120052,
0.0050423066,
0.004486663,
-0.017103605,
-0.004125814,
-0.01585181,
-0.026517615,
0.016630989,
0.039265484,
-0.00006212072,
-0.009484262,
0.011694063,
0.011853731,
0.020999499,
-0.0007931494,
-0.0071084066,
-0.028229252,
-0.007925905,
-0.024346134,
-0.00060713646,
-0.0087561775,
0.0028149418,
-0.016567122,
-0.002216188,
0.004090687,
-0.011336408,
0.0068273917,
-0.033951744,
0.011943145,
-0.035305724,
0.03203573,
0.017588995,
-0.005435089,
-0.009311821,
-0.008851978,
0.010410335,
0.010659417,
-0.004371702,
-0.0046974244,
-0.0066932705,
-0.005933252,
-0.0035573966,
-0.013360995,
-0.009241567,
0.012486015,
0.004352542,
-0.05277976,
0.01719302,
-0.017065285,
-0.029506594,
0.008903072,
-0.013463181,
0.027207378,
0.0021251773,
0.01969661,
0.014561696,
-0.005173234,
0.008341041,
-0.03568893,
-0.0322912,
0.018828018,
0.02295383,
0.016860912,
0.01589013,
0.0148554845,
-0.021101685,
0.022634495,
0.011029846,
0.0065719234,
0.014472282,
0.0070637,
-0.018074386,
0.0016956711,
0.003452016,
0.011112873,
0.009695023,
0.007740691,
0.020181999,
-0.012537109,
-0.00038380126,
-0.030937217,
0.03195909,
-0.0066932705,
-0.01760177,
-0.01767841,
0.007191434,
-0.0026440974,
-0.00033709846,
0.005840645,
-0.024231173,
0.018342627,
-0.012364668,
0.024652695,
0.0072169807,
0.0044036354,
-0.008309108,
-0.045882113,
0.009107446,
-0.038550172,
0.03913775,
-0.009656703,
-0.012632909,
0.011745157,
0.019057939,
0.0021922376,
-0.019121805,
-0.0026233406,
-0.012007012,
-0.009688637,
-0.0031374707,
0.0005261051,
0.01319494,
-0.005109367,
0.0015615503,
-0.036966268,
0.030962763,
0.013514276,
0.015098179,
0.010812698,
0.019466687,
-0.0042790947,
0.0025946004,
-0.006776298,
0.011476915,
0.013143847,
0.005894932,
0.006172754,
0.0148554845,
0.01921122,
-0.021472115,
-0.005786358,
-0.026262145,
-0.016835364,
0.020092586,
0.03213792,
0.022251293,
0.025406327,
0.026364334,
-0.0028261186,
-0.020922858,
-0.010403948,
0.0024508995,
0.0351269,
-0.005668204,
-0.00007863635,
-0.03277659,
-0.0034200824,
-0.041104857,
-0.014370094,
0.01760177,
-0.010212347,
0.03195909,
0.016388295,
0.008238854,
0.0015088599,
0.0018473555,
0.017052513,
-0.005147687,
-0.016324427,
-0.00089413923,
0.038218066,
0.0047389376,
0.0013172587,
-0.048947737,
-0.005783165,
0.020769576,
0.009318208,
-0.009497035,
0.009497035,
0.014893805,
-0.009490649,
-0.024116213,
0.004020433,
0.028459173,
-0.0028756156,
0.013258807,
-0.0063547753,
-0.000012424144,
-0.017065285,
0.0025179598,
0.013067205,
0.029404407,
0.012741484,
-0.015672984,
0.005642657,
0.015353647,
-0.0077023706,
-0.012319961,
-0.00655915,
-0.0034807562,
-0.0383458,
-0.0042950613,
0.009484262,
-0.01895575,
0.017205793,
0.008194148,
-0.006345195,
0.01067219,
-0.0355101,
0.0025610703,
-0.017499581,
0.02638988,
-0.008238854,
-0.0032604148,
0.029583234,
0.011936759,
0.010193187,
-0.009062739,
-0.005208361,
0.0067826845,
-0.00038739378,
0.026108865,
-0.025725663,
-0.015685756,
-0.008698697,
0.011425822,
-0.0024524962,
-0.0068210047,
-0.007402195,
-0.017499581,
-0.013629236,
0.009669477,
0.004668684,
0.015724076,
0.02776941,
0.0012326348,
-0.0024381261,
0.0065719234,
0.028586907,
-0.013795291,
-0.031243779,
0.010027133,
-0.0033019283,
-0.011745157,
0.020194773,
-0.0048059984,
-0.02687527,
-0.0013467972,
0.032342292,
0.008717857,
0.013258807,
0.005246681,
0.016937552,
-0.0025035897,
-0.022902736,
0.0054606358,
0.00081909535,
0.012275254,
-0.01057639,
-0.003927826,
0.0046112034,
0.011987852,
0.0059460257,
0.0079642255,
-0.023835197,
-0.022072464,
-0.013360995,
0.020501334,
-0.011796251,
-0.021663716,
-0.02960878,
0.025035897,
-0.009528969,
-0.0020357633,
-0.008238854,
-0.013003339,
-0.004090687,
-0.007779011,
-0.0013036869,
-0.0033370552,
0.017627316,
0.018265987,
-0.023234846,
-0.0055117295,
-0.01876415,
0.00050455,
-0.012051719,
0.0097333435,
-0.029021204,
0.004288675,
0.019390047,
-0.02470379,
0.0040332065,
0.009905785,
-0.020156452,
-0.022481214,
0.0042407745,
0.011457755,
-0.01827876,
-0.0017531515,
-0.0049880194,
0.0023024085,
0.0043589287,
0.012236934,
-0.026287694,
-0.0042695147,
-0.0019080292,
0.018738603,
0.020986725,
0.013143847,
-0.01779337,
-0.004920959,
-0.0046910373,
0.016899232,
-0.026070544,
0.011438595,
-0.003244448,
-0.009995199,
0.020795124,
0.0019894599,
-0.020437468,
-0.007363875,
0.00013192545,
-0.0023726623,
-0.012594589,
-0.017256886,
0.030221906,
0.018061612,
0.027590582,
0.00455053,
-0.017039739,
-0.0023934192,
-0.027743863,
0.015596342,
-0.0203736,
-0.033926196,
0.009726957,
0.0028372954,
-0.026211051,
-0.0022561047,
-0.010934046,
0.031192685,
0.014510602,
-0.02466547,
-0.025444647,
-0.012070879,
0.0043844753,
0.0010250667,
0.0064122556,
-0.0066230167,
-0.004662297,
0.025470193,
0.0068529383,
0.016937552,
-0.014395641,
-0.005668204,
-0.02833144,
-0.0033657954,
0.020667389,
0.003477563,
0.028152611,
0.0008797691,
-0.0093437545,
-0.026773082,
-0.003164614,
-0.023273166,
-0.01375697,
-0.012607363,
-0.011330022,
0.015532475,
0.024691015,
0.02695191,
-0.0018760957,
0.006211074,
-0.0022145913,
0.015685756,
0.005288195,
-0.010001586,
-0.0072169807,
-0.03816697,
0.011080939,
0.021612622,
-0.019709382,
0.027411753,
-0.022251293,
0.01783169,
0.028970111,
0.0045569167,
-0.028152611,
-0.016094506,
0.004266321,
-0.01884079,
0.010103773,
0.0016637376,
0.006884872,
-0.000079484584,
-0.027232926,
-0.010180414,
0.010838244,
0.01420404,
-0.037017364,
0.028867923,
-0.016273333,
0.021497661,
-0.0006123257,
0.0024333359,
-0.029200032,
-0.003748998,
-0.0028516655,
-0.0115088485,
0.014229586,
0.0032604148,
0.012913925,
0.027897144,
-0.012818124,
-0.011757931,
-0.0029698196,
-0.0001431022,
-0.03285323,
0.01327158,
-0.00036484073,
-0.032240104,
0.008245241,
-0.013642009,
-0.028740188,
-0.00799616,
-0.0017723116,
-0.03574002,
0.016043412,
-0.018713057,
-0.0043142214,
-0.018368173,
-0.024550509,
0.0128883775,
-0.049663045,
0.04557555,
0.025240272,
0.020271413,
-0.016554348,
-0.0020341666,
-0.004199261,
-0.00089493755,
0.018099932,
0.014012439,
-0.022327933,
-0.026900817,
-0.009452329,
0.00086859235,
-0.0119048245,
-0.048947737,
0.0012845268,
-0.006527216,
0.0033913422,
0.0012557866,
0.023822423,
-0.027232926,
0.00758741,
-0.0020645035,
-0.013884705,
-0.0049880194,
-0.011783478,
-0.027462848,
0.03648088,
-0.0064218356,
0.00562669,
0.0073255547,
0.00035047063,
-0.0069806725,
-0.033057604,
-0.014152946,
0.01368033,
-0.011796251,
0.01764009,
0.010039906,
0.016337201,
0.023107111,
0.029251125,
0.030221906,
-0.0006718019,
-0.007389422,
0.031167138,
0.0051349136,
-0.010819084,
0.031422608,
-0.0030544435,
0.0083538145,
0.0008406505,
0.0026313239,
-0.01771673,
-0.038141426,
-0.008858365,
0.008788111,
0.01760177,
-0.019415595,
-0.013808064,
-0.017486809,
-0.010282601,
-0.02313266,
-0.021472115,
0.020360827,
-0.036889628,
-0.015200366,
0.006769911,
-0.0056809774,
-0.003940599,
-0.0051444937,
0.00043629203,
-0.013475955,
0.01958165,
-0.0161456,
0.021318834,
0.0070509263,
0.026006678,
-0.024601601,
-0.013910252,
-0.022711135,
-0.03155034,
0.03001753,
-0.004205648,
-0.05610085,
0.010059066,
0.0005265043,
0.009726957,
-0.0016094506,
-0.00865399,
0.013258807,
-0.025738435,
0.018738603,
0.010065453,
-0.007172274,
0.007868425,
-0.017244114,
0.012473242,
0.0050518867,
-0.004445149,
0.0010705721,
-0.0007197022,
0.0009771665,
-0.008411296,
-0.0065336027,
-0.0049465057,
-0.007312781,
0.022366254,
0.0011017072,
-0.0019415594,
0.001711638,
-0.0075299293,
-0.010007973,
0.01327158,
0.009995199,
-0.036864083,
-0.009669477,
-0.0076129567,
0.0078109447,
-0.0044132154,
-0.015110953,
-0.012530723,
-0.01969661,
-0.0065463763,
-0.011611036,
0.02751394,
-0.017959425,
0.023107111,
0.0033849555,
-0.018074386,
-0.015123726,
0.0003484748,
-0.029762061,
-0.021689262,
0.0070892465,
0.008456002,
-0.012083652,
-0.0022002212,
-0.01371865,
0.012907539,
-0.0027622515,
0.0015894921,
-0.0073319413,
-0.0103336945,
0.01891743,
0.005118947,
0.032546666,
0.0026393074,
-0.020846216,
-0.014370094,
0.014970445,
-0.013092753,
-0.0023375354,
0.011106486,
0.010078226,
0.022098012,
-0.014472282,
0.043736182,
0.010978752,
0.019760476,
0.027794955,
-0.008411296,
0.011023459,
-0.002072487,
-0.010991526,
-0.03139706,
0.006884872,
-0.004470696,
0.030707294,
0.02078235,
-0.0022321546,
-0.02268559,
-0.0036244572,
-0.023056017,
0.019390047,
-0.007172274,
0.004761291,
-0.0006274941,
0.0095481295,
-0.0037266444,
0.0028309086,
0.007095633,
-0.029276673,
-0.001372344,
-0.009069126,
0.033057604,
0.0050327266,
-0.0091521535,
0.0083665885,
-0.02231516,
0.0045313695,
0.017129153,
-0.018585322,
0.0024748496,
0.026670896,
-0.007472449,
0.024537735,
-0.00091968605,
-0.0018489521,
-0.0032125143,
0.0018010518,
-0.013616463,
-0.006029053,
-0.0057703913,
-0.00023091944,
0.01719302,
-0.0074277422,
-0.002992173,
0.0007408582,
-0.012996952,
-0.010269827,
0.014433961,
0.18148471,
0.0011184723,
0.0071595004,
0.032418933,
0.020309733,
0.018138252,
-0.006884872,
-0.013986892,
0.009375689,
-0.005208361,
0.019556101,
0.014510602,
-0.014344548,
0.001473733,
-0.0072169807,
0.004959279,
-0.040517278,
-0.011847344,
-0.0027814116,
0.005272228,
-0.00202778,
0.0037809315,
-0.007223367,
-0.0068529383,
0.04996961,
0.021254966,
-0.020156452,
0.00454095,
-0.009573677,
-0.01921122,
0.00803448,
-0.012824511,
-0.007351102,
0.0213827,
-0.007542703,
-0.009132993,
-0.00861567,
-0.015264234,
0.014638336,
0.025176406,
0.021625396,
0.021880863,
-0.054619133,
-0.03178026,
0.01521314,
0.028127065,
-0.0101420935,
-0.043046415,
-0.024946485,
0.0074149687,
-0.021625396,
0.0000974971,
0.010895725,
0.037400566,
-0.014510602,
0.0049145725,
-0.0017946651,
0.030196358,
-0.011694063,
0.046597425,
-0.01424236,
0.0171547,
-0.0037010976,
0.024499414,
-0.012901152,
0.0262366,
-0.02101227,
-0.020194773,
0.020041492,
-0.0053329016,
-0.00704454,
-0.0026536775,
-0.016235013,
0.038703453,
0.025265818,
-0.0070509263,
-0.0076448903,
0.012639296,
-0.009631157,
-0.0005704129,
-0.018700283,
-0.01156633,
-0.03798814,
0.01480439,
-0.022034144,
-0.004742131,
0.029046752,
0.01581349,
0.000091160284,
0.01521314,
-0.0032699949,
-0.01827876,
0.0029650296,
0.012313575,
0.036634162,
0.001325242,
-0.018968524,
0.009611997,
0.004751711,
-0.010544456,
0.0008646007,
0.0686188,
0.01779337,
0.024243945,
-0.0028708256,
-0.0017052512,
-0.018138252,
-0.0010577986,
0.0011991046,
-0.0014545729,
0.0015743236,
-0.026696442,
0.0037362245,
-0.015200366,
-0.0026967877,
-0.003515883,
0.022442894,
-0.023107111,
0.014970445,
0.006479316,
0.0031869677,
-0.014995992,
0.02478043,
0.017435715,
-0.017103605,
-0.0015767186,
-0.03913775,
0.021727582,
0.024716562,
-0.03913775,
0.0113172475,
-0.00801532,
-0.007862038,
0.01610728,
-0.0066804974,
-0.011630196,
0.0051540737,
-0.006163174,
-0.008296334,
0.031754714,
-0.0076832105,
-0.000063517815,
0.022046918,
0.0048475116,
0.016005091,
-0.009822758,
0.014587242,
0.011457755,
-0.0077215307,
0.0015958789,
-0.016605442,
-0.017039739,
0.01517482,
-0.010154867,
0.013501502,
-0.0030336867,
-0.024014024,
-0.022174653,
0.021433795,
-0.003927826,
-0.00873063,
-0.00068178115,
0.02291551,
-0.038524628,
-0.030962763,
0.015328101,
-0.15839037,
0.014625562,
0.015966771,
-0.018751377,
0.011170354,
0.013143847,
0.0062781344,
0.0069295787,
-0.0038064783,
-0.008443229,
0.020552428,
-0.0009819565,
-0.023196526,
-0.034590416,
0.0054829894,
-0.009228794,
-0.011349182,
0.024026798,
0.03165253,
0.0142679075,
0.043812823,
-0.01071051,
0.013923025,
-0.03923994,
0.013616463,
0.012530723,
0.008487936,
-0.016579896,
0.03162698,
-0.013808064,
0.023081565,
-0.0075299293,
0.021842543,
0.002121984,
-0.0081558265,
-0.01484271,
-0.007172274,
0.009254341,
-0.0072872345,
0.011892051,
0.017371848,
-0.0005460636,
0.009829145,
0.000012274456,
-0.014216813,
0.01730798,
0.010621096,
-0.013207713,
0.026977457,
-0.03471815,
0.025457421,
-0.016554348,
0.0058534183,
0.02470379,
0.040057436,
0.0029346927,
0.0001859131,
0.026645347,
0.001829792,
-0.0018473555,
-0.027948236,
-0.007919518,
0.025265818,
-0.020181999,
0.028280346,
-0.042407744,
-0.022442894,
-0.023234846,
-0.026926363,
0.012952245,
-0.03832025,
-0.021459341,
-0.0111192595,
-0.016286107,
0.0044483426,
0.02287719,
-0.025623474,
-0.0063164546,
-0.007695984,
0.0018281953,
-0.029353313,
0.012415761,
-0.015430288,
-0.017180245,
-0.040082984,
0.0034903362,
0.016286107,
0.0012070879,
0.009005259,
-0.012530723,
0.014076306,
-0.033466354,
-0.021050591,
0.0013260404,
0.03221456,
0.022749456,
0.013654783,
-0.00203257,
0.005949219,
-0.005805518,
0.03849908,
-0.012141133,
-0.024767656,
0.0042311945,
0.019109033,
-0.0066741104,
-0.0031438572,
0.0013523855,
0.04600985,
-0.009912171,
0.0004430779,
-0.014421188,
0.010122933,
0.007255301,
-0.013475955,
0.0016541575,
-0.018891884,
-0.004317415,
0.03946986,
-0.027258473,
0.047414925,
0.010288987,
-0.015264234,
0.0040874933,
0.009324594,
-0.011598263,
-0.1298801,
-0.016797043,
-0.0006394692,
0.010046293,
0.016043412,
0.014995992,
0.015417514,
0.00355101,
0.018304307,
0.01226248,
-0.014561696,
-0.009758891,
0.00021734768,
-0.011687676,
0.0052402946,
0.010844631,
-0.012939472,
-0.00710202,
-0.049765233,
0.017882785,
0.0011839361,
-0.007172274,
0.0031773876,
-0.013475955,
-0.0026425007,
0.0024636728,
-0.022902736,
0.01767841,
0.01521314,
0.008341041,
-0.0062845214,
-0.021727582,
0.025610702,
-0.013028885,
0.0010905305,
0.010959592,
-0.0065399897,
-0.0002754268,
0.014574469,
-0.012894765,
0.0061983005,
0.010237894,
0.020207547,
-0.008404909,
0.013437635,
-0.011061779,
-0.019900983,
-0.013437635,
0.0004642339,
0.013169393,
-0.015762396,
-0.0040619466,
-0.06325396,
-0.007459676,
0.0131183,
-0.031345967,
0.009918558,
0.010435882,
-0.006310068,
-0.01958165,
-0.037885956,
0.021650942,
-0.004984826,
-0.012434921,
-0.000392583,
-0.010621096,
0.004288675,
-0.013974118,
0.030605108,
-0.023183752,
0.0057480377,
0.012965019,
0.0090819,
0.0024269493,
-0.020194773,
0.020539654,
-0.0019814763,
0.0004406829,
0.0010593953,
-0.017537901,
-0.0043142214,
-0.023017697,
0.026185505,
0.009209634,
-0.00563627,
0.01603064,
0.0058470317,
-0.0014298244,
-0.0070892465,
-0.05027617,
-0.0068018446,
0.010946819,
0.04197345,
-0.008781725,
-0.0054478627,
-0.0020996304,
0.031167138,
-0.012441308,
0.0407472,
0.012058106,
-0.024691015,
-0.01872583,
-0.038115878,
0.018087158,
0.019722156,
-0.003209321,
0.005048693,
-0.004652717,
-0.019530555,
-0.005706524,
0.007153114,
0.020565202,
-0.013386541,
0.016771497,
0.0015463819,
0.0013188553,
-0.02687527,
-0.019900983,
0.007945065,
0.013463181,
0.017588995,
0.022059692,
-0.0059907325,
0.016758723,
0.029838704,
0.005217941,
-0.02631324,
0.022238519,
-0.017984971,
-0.004208841,
-0.0057480377,
-0.007472449,
0.01610728,
-0.027871596,
-0.0087561775,
0.00253712,
-0.0016573509,
0.007421355,
-0.010225121,
0.017921105,
0.008807271,
0.016950324,
-0.013948572,
-0.017806144,
0.0065910835,
-0.012607363,
-0.004860285,
-0.022481214,
-0.020156452,
0.00078317017,
0.0016493675,
-0.017244114,
-0.0056011435,
0.03648088,
0.004406829,
-0.038524628,
-0.0053935754,
-0.008194148,
-0.0020900504,
-0.025431873,
-0.008698697,
-0.01965829,
0.013897478,
0.020028718,
0.022442894,
-0.00814944,
0.0006965504,
-0.025099766,
-0.008251628,
-0.0020006364,
0.026338786,
-0.0351269,
-0.04235665,
0.016605442,
0.00863483,
-0.008002546,
0.018393721,
-0.004751711,
-0.001060992,
-0.0030001565,
-0.00859651,
0.0011432208,
-0.012971405,
-0.0016397875,
-0.011955919,
0.02986425,
0.025253046,
-0.0050454997,
-0.0046303635,
0.041436967,
-0.013744197,
0.012735097,
-0.013948572,
0.0054829894,
-0.019964851,
0.006479316,
0.013667556,
-0.018087158,
-0.008877525,
0.010486975,
0.009228794,
0.0062430077,
-0.010486975,
-0.004553723,
-0.010812698,
-0.010295374,
-0.0063068746,
-0.014600016,
-0.009809985,
-0.033747368,
-0.031601433,
-0.008264401,
0.0081686005,
0.00871147,
0.03428385,
-0.0012438114,
-0.020833444,
0.014306228,
0.018061612,
0.02276223,
0.0034296624,
-0.0078109447,
0.012779804,
0.03775822,
0.018942978,
0.0014513795,
0.0056298836,
-0.0017180246,
0.0051349136,
0.0010841438,
0.036736347,
0.00033769722,
-0.026032224,
-0.020233093,
-0.020590749,
-0.0023087952,
-0.009113833,
-0.011049006,
0.022557855,
0.014600016,
-0.0011967096,
0.06723927,
-0.016924778,
-0.011955919,
0.0029953662,
-0.0005225126,
0.03443713,
0.023413673,
0.0055596298,
-0.030221906,
0.01069135,
-0.0056905574,
-0.008628443,
0.02384797,
-0.015711304,
-0.027462848,
0.030630654,
-0.01113842,
-0.003605297,
0.005901319,
0.014893805,
0.019160125,
-0.03221456,
0.00657831,
0.01573685,
-0.025776755,
-0.010851018,
0.045882113,
0.0069359657,
0.008040866,
-0.042586572,
-0.0091521535,
0.02388629,
-0.027897144,
-0.00037801333,
0.009765278,
-0.024269493,
-0.017244114,
-0.0076832105,
0.0066230167,
0.020565202,
0.0050039864,
0.007402195,
-0.007076473,
-0.021293286,
-0.029966436,
0.0005456644,
-0.02687527,
-0.022557855,
-0.006345195
] |
Targeting of αVβ3 and αVβ5 integrins by cilengitide may reduce growth of solid tumors including head and neck squamous cell carcinoma (HNSCC). Preclinical investigations suggest increased activity of cilengitide in combination with other treatment modalities. The only published trial in HNSCC (ADVANTAGE) investigated cisplatin, 5-fluorouracil, and cetuximab (PFE) without or with once (PFE+CIL1W) or twice weekly cilengitide (PFE+CIL2W) in recurrent/metastatic HNSCC | [
-0.015088795,
0.011761805,
0.009345941,
-0.009339039,
0.01507499,
0.021784188,
-0.030453688,
-0.013542642,
-0.033490773,
-0.024296688,
0.029625392,
0.015461528,
0.009725577,
0.035174977,
-0.01079546,
-0.002738554,
0.035395857,
-0.0056427675,
-0.020376084,
0.0059706345,
-0.030619347,
0.0037376864,
0.011699683,
-0.010850679,
-0.020624574,
0.006840346,
-0.0037825524,
-0.03716289,
0.0027592615,
-0.017877392,
0.009180282,
0.010622898,
-0.009125062,
0.011644463,
-0.003644503,
0.02494552,
0.01700768,
-0.028382948,
0.0054667545,
-0.0037204302,
0.02802402,
-0.0078066913,
0.01613797,
-0.006136294,
-0.048620984,
-0.0026971393,
0.0010258793,
-0.011209608,
0.0008930068,
0.018139686,
-0.006550442,
0.007951643,
0.005535779,
-0.0017402847,
-0.016220799,
-0.02134243,
0.013107787,
0.031530473,
-0.008800646,
-0.0036790154,
-0.009497796,
-0.00016059024,
-0.010457239,
0.008855866,
-0.004824825,
-0.011575439,
-0.0074684704,
-0.016317435,
0.0029991223,
0.0053183516,
0.0316133,
0.024683226,
-0.018622858,
-0.018595248,
0.020348476,
-0.014274304,
-0.04108349,
0.0056427675,
0.000040201485,
0.005401181,
0.004621202,
-0.021466674,
0.01725617,
0.026187964,
0.013832546,
0.021701358,
-0.014881721,
-0.009318331,
-0.016690167,
0.0007169939,
0.021604724,
0.010802362,
-0.0015832536,
0.02128721,
-0.008786841,
0.01583426,
0.0010543519,
0.002391705,
0.006298502,
-0.02159092,
0.017490854,
0.010174238,
-0.004969777,
-0.011741098,
-0.019340714,
-0.01079546,
-0.005839488,
0.0009620315,
0.015240649,
0.0049042036,
-0.012314003,
0.026684942,
-0.0040517487,
-0.03934407,
0.020776428,
-0.006429649,
0.0257324,
0.025511522,
-0.02696104,
-0.012790273,
0.01728378,
0.008621182,
0.03199984,
-0.02368927,
0.03716289,
0.0042312127,
-0.0015547809,
-0.0068196384,
-0.0012674656,
-0.02455898,
0.028659048,
0.0038688332,
0.008020667,
-0.010222555,
0.0040103337,
-0.0049076546,
-0.008814451,
-0.022640094,
-0.021742774,
-0.017559879,
0.0059257685,
0.02690582,
-0.01686963,
0.017946417,
-0.031143935,
0.0017825624,
0.010954216,
0.000067299065,
0.0032717697,
-0.008186327,
-0.0048765936,
-0.042353544,
0.014074132,
0.008634987,
-0.009311429,
0.012244978,
-0.015723823,
0.03641742,
-0.00024288059,
-0.0014538323,
-0.006167355,
-0.027927386,
0.020610768,
0.008386498,
0.021135356,
0.018001636,
0.008393401,
0.0056462185,
-0.020514134,
-0.027195724,
0.00858667,
0.044783212,
-0.04108349,
0.008952501,
-0.017960222,
-0.005339059,
0.017932612,
0.021093942,
-0.02791358,
-0.019340714,
-0.0050664116,
0.014129352,
0.017960222,
-0.0019982646,
-0.01012592,
0.011872245,
0.018816128,
-0.0014754025,
-0.013466715,
-0.035699565,
-0.0077169593,
0.016634949,
0.0003056499,
-0.039371677,
-0.6206699,
-0.06002386,
0.022253556,
-0.010464141,
0.014881721,
0.030646957,
0.027402798,
-0.02156331,
-0.017021487,
-0.0005629825,
0.0037514912,
0.015475333,
0.0020431306,
0.008931793,
-0.028879926,
-0.028824706,
-0.010533166,
-0.013011152,
-0.0036306982,
-0.0049766796,
-0.002995671,
0.009359746,
0.005911964,
0.0045556286,
0.030757397,
-0.0032320805,
0.036279373,
-0.015447723,
-0.008593572,
0.023868734,
-0.024600396,
0.03498171,
-0.027292358,
-0.006871407,
0.05809117,
-0.018885152,
-0.00794474,
0.005708341,
0.015199235,
0.035340637,
0.00040120594,
-0.0032545137,
0.009573723,
0.01177561,
-0.021977458,
-0.00909055,
0.019644424,
0.001022428,
0.0035754784,
-0.0022985218,
0.022446826,
0.0039482117,
-0.023040438,
0.002495242,
0.008310571,
-0.01345291,
0.038350113,
-0.011175095,
-0.006032757,
0.002693688,
-0.0067195524,
0.011699683,
0.0042588226,
-0.05798073,
-0.00031255238,
0.023965368,
-0.020748818,
0.011002534,
0.01809827,
0.0015539181,
0.026339818,
0.022253556,
0.00008795254,
0.010726435,
0.03481605,
0.050029088,
0.000551766,
0.011996489,
0.00084900355,
0.0057324995,
0.009332136,
-0.010374409,
-0.014025815,
0.03155808,
0.016842023,
0.010912802,
-0.046964392,
0.0077238614,
0.013577155,
0.000103590944,
0.015875677,
0.002847268,
-0.01350813,
-0.042077444,
-0.0069369804,
0.028824706,
0.017532269,
-0.0027092188,
-0.007240689,
-0.021107746,
-0.015323479,
-0.00967726,
-0.004924911,
-0.007710057,
0.015571968,
0.0037411377,
-0.037880745,
-0.009249307,
0.018567638,
-0.037466597,
-0.010063798,
-0.0008425325,
-0.01289381,
-0.018401979,
-0.009111257,
-0.020514134,
0.0023278573,
0.0028731523,
-0.00075582025,
-0.037853133,
0.0042450177,
-0.0010370958,
-0.006050013,
0.00620877,
0.018967982,
-0.0075996174,
-0.00255909,
-0.009332136,
0.002419315,
-0.023937758,
-0.0055806455,
-0.016717777,
0.010947314,
-0.018567638,
0.013804936,
0.016469289,
0.0076617394,
-0.004458994,
-0.01588948,
-0.012962835,
-0.026022304,
-0.0033511482,
0.01935452,
0.020182816,
-0.005618609,
-0.0054184375,
-0.026256988,
0.017905002,
-0.0037411377,
-0.005518523,
0.01946496,
-0.009359746,
0.0020172463,
0.020458914,
0.019892912,
-0.0073097134,
0.025801426,
-0.035671953,
0.0029801405,
-0.03857099,
0.0043002376,
0.015737627,
-0.0005590999,
-0.036859177,
-0.011320047,
-0.011375267,
0.005680731,
0.0022622838,
0.017794563,
-0.042187884,
-0.009960261,
-0.015696213,
-0.008676402,
0.03699723,
-0.0037929062,
0.006339917,
-0.010581483,
-0.001721303,
-0.008158717,
0.019865302,
-0.006108684,
-0.03407058,
0.0023175036,
0.014315719,
0.018995592,
0.0023779003,
0.020955892,
0.020320866,
0.009939554,
0.02148048,
-0.024793664,
0.006415844,
-0.007344226,
0.013038762,
-0.0027713408,
-0.011685878,
0.01583426,
0.010898997,
-0.021867018,
0.013867058,
0.014481378,
-0.0025556388,
0.009518503,
-0.010512459,
0.03815684,
-0.0073787384,
-0.0020741916,
-0.006132843,
0.022722924,
-0.009580625,
0.010636703,
0.015351089,
-0.02131482,
0.007213079,
-0.018001636,
0.002729926,
-0.008041375,
-0.041690905,
0.0036203444,
0.0010733338,
-0.011603049,
0.009684162,
0.0017144005,
-0.019064616,
-0.008766134,
0.025028348,
0.012458955,
0.010381312,
-0.0025521875,
-0.014163864,
-0.013280348,
0.014495183,
0.018829932,
0.008379596,
0.008572865,
0.02483508,
0.018167296,
-0.011948172,
0.028741876,
-0.015364894,
0.025318252,
0.018415784,
-0.018650468,
0.012804078,
-0.0012545235,
0.02360644,
0.04147003,
0.005000838,
-0.0025401083,
0.027306164,
0.008572865,
0.02050033,
-0.014854111,
0.0065538934,
0.01586187,
-0.009483991,
0.0038998944,
0.033021405,
0.059747763,
0.020403694,
0.023192292,
-0.018222515,
0.0013563349,
0.0060258545,
-0.00007193666,
0.023399366,
0.018443394,
-0.005518523,
-0.020817842,
-0.010332994,
0.0031889402,
-0.009642747,
0.03227594,
-0.041773736,
-0.0052286196,
0.007330421,
-0.0023175036,
0.006943883,
0.010312287,
0.0062639895,
0.013756619,
-0.058643367,
0.01932691,
0.0017946416,
-0.012880005,
-0.010747142,
-0.011713488,
0.024793664,
0.010705728,
0.02148048,
-0.00791713,
0.0037687474,
0.0011811848,
0.031585693,
-0.002698865,
-0.018760908,
0.016220799,
-0.010843777,
0.013936083,
-0.008269156,
0.0015418387,
-0.0063054045,
0.0001377258,
-0.025166398,
0.052734856,
0.009615138,
-0.02273673,
-0.04097305,
-0.023537416,
-0.01172039,
-0.002757536,
-0.019423544,
-0.010326092,
-0.012845493,
0.0027143955,
0.0015668602,
0.01837437,
0.004327847,
0.035174977,
-0.014785086,
-0.029929101,
-0.015627187,
0.007289006,
-0.024117222,
0.01289381,
0.006046562,
0.009442576,
0.006050013,
0.0036065395,
-0.0071440544,
-0.009442576,
-0.023068048,
-0.003986175,
-0.038460553,
-0.005432242,
-0.012597004,
-0.0014408901,
0.004693678,
0.018760908,
0.022474436,
-0.0068955654,
-0.030564127,
-0.01605514,
0.012017197,
0.013135397,
-0.012590102,
0.046163704,
0.018567638,
0.037190497,
0.0037273327,
0.028824706,
0.015599578,
0.006978395,
-0.0034443315,
0.0020051668,
0.00073856406,
-0.000950815,
0.031199155,
-0.01599992,
-0.054805595,
-0.007820496,
0.01515782,
0.0048144716,
-0.002031051,
0.007164762,
0.010326092,
0.014978356,
-0.005691085,
-0.0019585753,
-0.024420932,
0.0014555579,
0.014453768,
-0.0012562491,
-0.013901571,
0.002590151,
-0.011665171,
0.009787699,
-0.02595328,
0.004769605,
0.004762703,
-0.007834301,
-0.017711733,
-0.008607377,
-0.03644503,
-0.0023226805,
-0.019175056,
-0.007654837,
-0.027458018,
-0.023109462,
-0.011941269,
-0.012728151,
-0.008814451,
-0.011540926,
-0.008276059,
0.0077031543,
-0.012997347,
-0.0223778,
0.015558163,
0.029432124,
0.011340755,
0.022018872,
0.0057152435,
-0.018691882,
0.04158047,
0.0050526066,
0.0077031543,
0.0037963574,
-0.04293335,
-0.006609113,
0.0075582024,
-0.0018170747,
-0.008938696,
-0.0067782234,
0.010084505,
0.0075029824,
-0.00040961834,
0.014881721,
-0.023357952,
-0.014439963,
0.00676787,
0.015599578,
0.0029335488,
-0.002374449,
0.0044658966,
0.003280398,
-0.024517566,
-0.0009810133,
-0.016276019,
-0.00084296387,
0.004179444,
0.02270912,
0.013045664,
-0.018222515,
-0.006301953,
0.0002622938,
-0.015668603,
-0.0016721229,
-0.00450386,
0.016013725,
0.027789336,
-0.0056703775,
0.01029158,
-0.008938696,
-0.0013994754,
-0.012286393,
0.0057186945,
0.005031899,
-0.011423584,
-0.014412353,
0.010194945,
0.005546133,
-0.00855906,
-0.029349294,
0.019313104,
-0.001486619,
0.033545993,
0.013280348,
-0.0044762506,
-0.0038619307,
-0.00802757,
-0.023910148,
-0.018678078,
-0.02785836,
-0.03890231,
0.0019741058,
0.0058222315,
0.01071263,
-0.0056393165,
-0.0033304407,
-0.02379971,
-0.008987013,
0.0067920284,
-0.007937838,
-0.0030129272,
-0.009097452,
-0.0067609674,
0.00039991175,
-0.014370938,
-0.022391606,
-0.018401979,
-0.017766953,
0.002676432,
0.041331977,
0.044120576,
0.017753147,
0.005608255,
-0.00030715982,
0.026533086,
0.00397237,
0.012189758,
-0.020969698,
0.028631438,
-0.030536518,
0.024393322,
0.0034132705,
0.003059519,
0.023496,
0.018567638,
0.00909055,
0.003927504,
-0.011761805,
-0.023206098,
-0.0041518346,
-0.03647264,
-0.03710767,
0.003937858,
-0.0039792727,
-0.0027696153,
-0.035561513,
-0.018595248,
0.00808279,
0.012479662,
-0.006036208,
0.006046562,
0.022101702,
0.014536598,
0.010112115,
-0.0038515772,
0.00909055,
-0.008262254,
-0.013804936,
0.013666887,
-0.033325113,
0.026602112,
0.016179385,
-0.010339897,
0.008379596,
-0.00911816,
-0.012541784,
0.026864406,
-0.017187145,
-0.01812588,
-0.004383067,
-0.028741876,
-0.0015737627,
-0.010415824,
-0.012824785,
-0.017697928,
0.0016298452,
0.0025832485,
-0.02788597,
0.018705688,
-0.008731622,
-0.0047765076,
0.022833364,
-0.016013725,
0.016855827,
-0.0282449,
0.031033495,
0.022529656,
0.0007290732,
-0.0341258,
-0.010754045,
-0.014647037,
-0.0037929062,
0.03257965,
0.03448473,
0.005991342,
-0.0015064636,
0.0030474395,
0.020141402,
-0.03492649,
-0.03597566,
0.014232889,
0.008883476,
0.015571968,
-0.03476083,
-0.043402717,
-0.02701626,
0.028203484,
0.0019516728,
-0.006360624,
-0.008158717,
-0.0044935066,
-0.010471044,
0.031061105,
-0.017863587,
0.024489956,
0.012120734,
-0.0014978355,
-0.010381312,
-0.033932533,
-0.012769566,
0.021770384,
-0.007316616,
0.010774752,
-0.0037652962,
-0.018567638,
0.010132823,
-0.02156331,
0.03230355,
-0.009270014,
0.008759232,
0.03928885,
-0.011706586,
-0.007002554,
0.023910148,
-0.010954216,
0.026546892,
-0.011230315,
0.0071302494,
-0.0062915995,
-0.04519736,
-0.014246694,
0.022336386,
0.03006715,
-0.0035340635,
0.0037204302,
-0.015295869,
-0.0034167217,
-0.019906718,
0.0067368085,
0.025884254,
-0.054695155,
-0.023785904,
0.0040793587,
0.0058049755,
0.0388747,
0.0054667545,
0.003040537,
0.019975742,
0.032910965,
-0.031806573,
0.005811878,
0.027665092,
0.016248409,
-0.018926566,
0.0007303674,
0.012169051,
-0.039564945,
0.0023313086,
-0.021356236,
-0.000588004,
-0.013694496,
-0.0073097134,
0.0052596806,
0.02595328,
-0.019368324,
0.0038412234,
0.009870529,
0.033407945,
-0.012493467,
-0.01132695,
-0.006771321,
-0.01804305,
-0.002427943,
0.033214677,
-0.0072613964,
-0.0043312986,
-0.01907842,
0.008248449,
0.011347657,
-0.010194945,
-0.01801544,
-0.022129312,
-0.01722856,
-0.010332994,
-0.0066436254,
-0.013577155,
-0.013873961,
-0.019975742,
0.009946456,
0.00093701005,
-0.021936042,
-0.008579767,
-0.014867916,
-0.012355418,
0.008345083,
-0.03235877,
0.0064123925,
-0.016814413,
-0.025911864,
-0.037521817,
-0.0038412234,
-0.0054184375,
0.019699644,
0.02019662,
-0.017394219,
-0.024876494,
-0.03465039,
-0.042712472,
-0.0000014880076,
0.01689724,
0.015848067,
-0.00018388606,
0.013673789,
-0.011175095,
0.017573683,
-0.0060085985,
-0.013666887,
0.013107787,
-0.003023281,
0.013045664,
-0.029846271,
0.011016339,
0.011209608,
-0.039923873,
-0.004445189,
0.01345291,
0.014219084,
-0.011119876,
0.02044511,
-0.005414986,
0.021604724,
-0.018112076,
0.004162188,
0.01815349,
0.0037100764,
0.0011993038,
-0.0075443974,
-0.0074132504,
0.018526224,
-0.012051709,
0.009028428,
0.00038092994,
-0.0075513,
0.0001784935,
-0.0004568571,
-0.011057754,
-0.032966185,
0.009877431,
-0.019892912,
-0.016151775,
0.00045599428,
0.00514579,
0.006132843,
0.010443434,
0.012610809,
-0.0028351888,
0.020030962,
-0.018857542,
-0.021273406,
0.02145287,
-0.004662617,
-0.00453147,
-0.00055219745,
0.008655694,
-0.017780757,
-0.0036341494,
0.00013999068,
-0.002950805,
-0.0020396793,
0.022529656,
-0.015254454,
-0.006978395,
-0.024572786,
-0.00043011003,
-0.012072416,
-0.011892952,
-0.019658228,
0.016552119,
-0.025635766,
-0.0015823907,
0.020113792,
-0.00397237,
0.0009663455,
-0.0006000833,
0.010774752,
-0.020845452,
0.00051509665,
0.20994547,
0.022032678,
0.0009939554,
0.020886868,
-0.0060258545,
0.0044797016,
0.016220799,
-0.003045714,
0.021176772,
0.009836017,
0.021577114,
-0.010995631,
-0.00025927395,
-0.008621182,
0.010402019,
0.0013269995,
-0.022198336,
-0.023730684,
-0.012997347,
-0.033352725,
0.0014408901,
0.020514134,
0.01700768,
0.002022423,
0.0050974726,
-0.0021829056,
-0.003848126,
0.00967726,
0.015654797,
-0.000052900945,
-0.023109462,
0.030895445,
0.014578012,
-0.009187185,
0.0045073116,
-0.008814451,
-0.015737627,
-0.0034961,
-0.0009982694,
0.0035892832,
-0.0050111916,
-0.023344146,
-0.024048198,
-0.018471004,
-0.00030025735,
0.025456302,
0.016966267,
0.00074805494,
0.017049097,
0.011347657,
-0.044092964,
0.012265686,
0.029708222,
0.0226539,
0.012721248,
0.007061225,
0.030674567,
-0.00033994653,
0.002229497,
0.02788597,
-0.0020327768,
-0.0014590091,
-0.0044900556,
0.011948172,
-0.0034408802,
0.009387356,
-0.028231094,
0.017697928,
0.0055081695,
-0.0014840306,
0.019961936,
-0.018843736,
-0.020859258,
0.02469703,
-0.020265646,
-0.031806573,
0.03172374,
0.006091428,
0.0316133,
0.024766054,
0.013632374,
0.006267441,
-0.0032493367,
0.014508988,
-0.011409779,
-0.023482196,
0.0052631316,
0.0020759173,
-0.009656552,
0.0026332915,
-0.0015832536,
0.008628085,
0.0008744564,
-0.0072337864,
0.031447645,
0.0070577734,
-0.01180322,
0.014232889,
0.012403735,
0.002553913,
-0.04147003,
0.070239514,
0.008669499,
-0.003221727,
0.012631516,
0.008945598,
-0.006295051,
-0.0012821334,
-0.007433958,
-0.0016842021,
-0.010139725,
-0.019754862,
-0.0011941269,
-0.013307958,
0.00861428,
0.024117222,
-0.011644463,
-0.04108349,
0.022584874,
-0.005073314,
0.020914478,
-0.015696213,
0.009780797,
0.046356976,
-0.005590999,
0.014398548,
-0.01586187,
-0.0009646199,
0.0069714924,
-0.029432124,
-0.01065741,
-0.0065090274,
0.00018302325,
-0.006664333,
0.015723823,
0.004648812,
0.022999022,
-0.013052567,
-0.020030962,
0.023675464,
-0.009980968,
-0.01132695,
0.007420153,
0.013080177,
0.010747142,
-0.013232031,
0.011361462,
-0.006370978,
-0.018415784,
-0.040144753,
-0.010961119,
-0.03390492,
0.006108684,
0.0070439684,
0.037604645,
-0.015848067,
0.0015556437,
-0.020721208,
0.017159535,
0.030950665,
-0.026049914,
-0.002716121,
0.027319968,
-0.016096555,
-0.0073994454,
0.0027005905,
-0.17570922,
0.0026816088,
0.020804038,
-0.0453078,
0.020596964,
0.013694496,
-0.012341613,
-0.019147446,
-0.0008528862,
0.0034132705,
0.02464181,
0.0011811848,
-0.028175874,
-0.007123347,
0.02262629,
0.007068127,
-0.010229457,
0.020873062,
0.006457259,
0.014101742,
0.024821274,
-0.01916125,
0.013473617,
-0.0018377821,
0.009339039,
0.007185469,
-0.012569394,
-0.031972233,
-0.026574502,
0.0038998944,
0.012244978,
0.0068334434,
0.03661069,
-0.0007515062,
0.007827398,
-0.00067514763,
-0.010940412,
0.025829036,
-0.0036686617,
0.022888584,
0.059858203,
0.012341613,
0.017670318,
-0.007050871,
-0.013018055,
0.019713448,
0.001829154,
-0.014343329,
0.022722924,
0.004058651,
0.03445712,
-0.010933509,
0.0058912565,
0.009967163,
0.031502865,
0.009525406,
0.037300937,
-0.0062777945,
0.012583199,
-0.0038377722,
0.011817025,
-0.0033977397,
0.013860156,
-0.008490035,
-0.016206995,
-0.035202585,
-0.0014495183,
0.016510703,
-0.017504659,
0.019478764,
-0.028990366,
0.005328705,
0.0058049755,
-0.008462425,
0.033242285,
0.012983542,
-0.012314003,
0.012583199,
-0.016538313,
0.01720095,
0.0023036986,
0.00077005656,
-0.02494552,
-0.023565026,
-0.010512459,
0.010885192,
0.022943804,
0.012873103,
0.005767012,
0.0038274184,
0.005207912,
-0.022101702,
0.003540966,
-0.024089614,
0.008144912,
0.01913364,
0.005960281,
0.010194945,
-0.006843797,
-0.00079852925,
0.020596964,
-0.031420033,
-0.011437389,
-0.00017881706,
0.01082307,
0.010974924,
-0.011506414,
-0.0020431306,
0.02027945,
0.0076479344,
-0.01940974,
0.012010294,
0.0034391547,
0.001527171,
-0.019754862,
0.027747922,
-0.022239752,
0.0029490795,
-0.01709051,
-0.021867018,
0.06029996,
0.01599992,
0.006802382,
0.004410677,
0.0078066913,
-0.013024957,
-0.13219607,
-0.013314861,
0.0192993,
0.007930935,
-0.017615099,
0.03476083,
0.0008869671,
0.013494325,
-0.014647037,
0.02363405,
0.001680751,
-0.014081035,
-0.018471004,
0.016372655,
0.026049914,
-0.010954216,
0.031033495,
-0.01236232,
-0.010312287,
0.03407058,
-0.009601333,
0.015061185,
-0.008842061,
-0.03862621,
-0.0074270554,
0.008924891,
-0.030978275,
0.0069680414,
0.025387278,
0.016842023,
-0.00009043312,
-0.004735093,
0.031061105,
0.019920522,
-0.018001636,
-0.012583199,
-0.018415784,
-0.02368927,
0.012583199,
-0.048869472,
0.0010086232,
0.0075858124,
-0.004969777,
-0.0034771182,
-0.00074891775,
-0.013418398,
-0.009518503,
-0.0020189718,
0.028769486,
-0.012652224,
-0.02243302,
-0.026436452,
-0.021383846,
0.008282961,
0.007834301,
-0.007875716,
0.0032942027,
0.01720095,
-0.016676363,
-0.022722924,
-0.03423624,
-0.014219084,
-0.022805754,
0.0018981787,
0.016414069,
0.011471902,
-0.0035150817,
-0.031033495,
0.0057601095,
0.001703184,
-0.009366649,
0.0043727136,
-0.028327728,
0.00853145,
-0.019092226,
-0.005045704,
0.011458097,
-0.019851498,
-0.0016643576,
-0.01591709,
-0.028231094,
-0.023482196,
0.030453688,
-0.010312287,
0.020762624,
-0.003339069,
0.0021794543,
-0.014702257,
0.018443394,
-0.004117322,
-0.0016531411,
0.03233116,
0.004679873,
-0.025207812,
0.0004182464,
0.00481102,
-0.005811878,
-0.0062191235,
0.025318252,
0.043927304,
-0.026339818,
0.0036306982,
-0.076700225,
0.003099208,
0.0041276757,
0.002914567,
0.012424442,
-0.008013765,
0.00864189,
-0.0001573547,
0.006578052,
0.0053804736,
-0.013356276,
0.037632257,
-0.016179385,
0.008441718,
-0.023109462,
-0.013570252,
0.034042973,
0.0038274184,
-0.00015066793,
0.0246142,
-0.003744589,
-0.032496817,
0.008993915,
0.002757536,
-0.003599637,
0.018277735,
-0.0033770325,
0.024710836,
-0.0015030124,
-0.008062082,
0.032552037,
-0.033435553,
-0.012534882,
-0.0049214596,
-0.012631516,
-0.020748818,
-0.002757536,
0.029514953,
0.0011829104,
0.010995631,
-0.008911086,
-0.02581523,
0.026201768,
0.011506414,
-0.0038239672,
0.012686736,
-0.020665988,
0.031199155,
0.0055668405,
0.018940372,
0.0063675265,
0.008752329,
0.001135456,
-0.026339818,
-0.006723004,
-0.005190656,
-0.006667784,
-0.029432124,
-0.033269897,
-0.021604724,
0.02273673,
0.021963652,
-0.0029973967,
0.011251023,
0.03614132,
0.0005892982,
-0.03211028,
0.013169909,
-0.019230276,
-0.018995592,
-0.028741876,
-0.014177669,
-0.005235522,
0.0026557245,
0.0035288867,
-0.014619427,
-0.024904104,
-0.00906294,
-0.00087747624,
0.030646957,
0.017780757,
-0.013314861,
-0.012562492,
0.013597862,
0.00506296,
0.007565105,
-0.016759193,
0.008400303,
0.011637561,
-0.0009171654,
0.022170726,
0.009663455,
-0.0050249966,
-0.0011613403,
0.009180282,
0.03017759,
-0.007392543,
-0.0013753168,
-0.0049973866,
0.018940372,
0.0016936931,
0.00478341,
0.013729009,
0.0037963574,
-0.015268259,
0.021273406,
-0.018567638,
-0.017463244,
-0.010374409,
0.008690207,
0.04274008,
-0.00011356717,
0.02058316,
-0.009083648,
-0.006899017,
-0.0049076546,
0.017656513,
0.011119876,
-0.02254346,
0.04320945,
0.0041828956,
0.006664333,
0.020265646,
-0.0041725417,
0.022363996,
-0.023137072,
0.018194905,
0.003487472,
0.031116325,
-0.013590959,
0.0020741916,
-0.008096595,
-0.017766953,
0.004690227,
0.0020931733,
-0.028410558,
-0.000488781,
-0.0031440742,
-0.024158638,
0.09194087,
0.0011570262,
-0.04135959,
-0.00562206,
-0.041608077,
0.010567678,
0.00045426868,
0.014716062,
-0.03630698,
-0.035064537,
-0.0053666686,
-0.014716062,
0.0063226605,
-0.03661069,
-0.02137004,
0.0061293915,
-0.021204382,
0.025856644,
0.021038722,
-0.0014357134,
0.018816128,
-0.02363405,
-0.0055840965,
-0.01135456,
-0.037356157,
-0.009760089,
0.0009939554,
0.00967726,
-0.010270872,
-0.042049836,
0.0007471921,
0.0018153491,
-0.01837437,
-0.013991303,
0.011865342,
0.012652224,
-0.0051837536,
-0.0223778,
0.009877431,
0.03023281,
0.00003275976,
0.021867018,
-0.022695314,
-0.049946256,
-0.00037014484,
-0.013991303,
-0.017131925,
-0.008600475,
0.0057152435
] |
Despite over a century of research, tuberculosis remains a leading cause of infectious death worldwide. Faced with increasing rates of drug resistance, the identification of genes that are required for the growth of this organism should provide new targets for the design of antimycobacterial agents. Here, we describe the use of transposon site hybridization (TraSH) to comprehensively identify the genes required by the causative agent, Mycobacterium tuberculosis, for optimal growth. These genes include those that can be assigned to essential pathways as well as many of unknown function. The genes important for the growth of M. tuberculosis are largely conserved in the | [
-0.030644892,
-0.028018188,
-0.0026432879,
-0.050703365,
-0.0031706188,
0.01820121,
-0.014831597,
-0.012191626,
-0.041868087,
-0.0003693804,
0.008841914,
-0.0022718345,
0.01572043,
0.01756443,
-0.0052202446,
0.0193819,
0.034385957,
-0.001473376,
0.002104349,
-0.009186834,
-0.007508662,
0.0024210792,
-0.014009094,
0.007926547,
-0.012868201,
0.033006273,
0.026771165,
-0.039957754,
-0.03847194,
-0.0015305863,
0.0014344065,
0.00034139704,
-0.027991654,
-0.020721784,
-0.027991654,
-0.032794014,
0.016980719,
-0.019992145,
0.016277611,
-0.009836878,
0.008649554,
0.019143108,
-0.005545266,
0.0064738994,
0.012848302,
0.0058570215,
-0.0067723887,
-0.020443194,
-0.027089555,
-0.003754331,
0.0017859604,
0.029504,
-0.03183885,
-0.0021623885,
-0.0065369136,
-0.009730748,
0.0038173452,
0.032024577,
-0.000552205,
-0.015348978,
-0.00589682,
-0.012881468,
-0.044521324,
0.019740086,
-0.009631252,
0.008351065,
-0.006404252,
0.019700287,
0.013120259,
0.015481641,
0.03955977,
0.01648987,
0.02435672,
0.037251454,
0.01648987,
-0.019289035,
-0.0057542087,
0.0066430434,
-0.0004228597,
0.025961928,
0.016596,
-0.009067439,
0.003256849,
0.0038372446,
0.008550057,
0.0027245432,
0.025351683,
0.013518245,
0.0033745863,
-0.0047990433,
0.0022917339,
0.02313623,
0.0052301944,
0.021968806,
-0.030087713,
0.015375511,
0.010314461,
0.03149393,
-0.010500187,
-0.03934751,
-0.0068917843,
-0.009153669,
0.0072566043,
-0.020403396,
-0.014208087,
0.026983425,
-0.0009535072,
-0.004732712,
-0.0016408615,
-0.020642187,
-0.013060561,
0.04367229,
-0.018121611,
-0.04592754,
0.011992633,
-0.0106262155,
0.017856289,
-0.00709741,
0.010632849,
-0.014725468,
0.027912058,
0.0004547815,
-0.001564581,
-0.02195554,
0.018917583,
0.0035586546,
-0.01972682,
-0.0021955539,
-0.0066629425,
-0.009956273,
0.00070352247,
0.01593269,
0.017139914,
0.004868691,
-0.027023222,
0.007953079,
-0.026850762,
-0.024237324,
-0.021929007,
-0.034810476,
-0.00009488433,
0.041629296,
-0.013332518,
-0.018625727,
0.015455108,
0.02682423,
0.01282177,
0.031361267,
0.010579784,
0.03210417,
0.011753841,
-0.0042783455,
0.0128615685,
-0.01889105,
0.00636777,
-0.005415921,
-0.012689108,
0.009021007,
0.005057734,
-0.010069036,
0.006792288,
-0.0016665647,
0.007734187,
0.000867277,
0.032449093,
0.036243223,
-0.003167302,
-0.0064639496,
0.016927654,
0.0013946079,
0.007442331,
0.009803712,
-0.013385583,
0.024277123,
0.0047592446,
0.013047295,
-0.003747698,
0.009213367,
-0.010752245,
0.0034657915,
-0.0052799424,
0.041629296,
0.025391482,
0.016383741,
-0.014247885,
0.0022900756,
0.014831597,
0.004931705,
0.0136376405,
-0.041841555,
-0.004228597,
-0.0020131439,
0.024144461,
-0.0055286833,
-0.626164,
0.003621669,
-0.00949859,
-0.03295321,
-0.01586636,
0.003936741,
0.019182907,
-0.004828892,
-0.014460144,
0.031228604,
-0.0055850646,
0.023295425,
0.03520846,
-0.024170993,
-0.018214475,
-0.026890561,
-0.007309669,
-0.017577698,
0.030538762,
0.017192978,
0.002177313,
0.002377964,
-0.012145194,
0.02000541,
0.0017959101,
0.024091396,
0.028018188,
-0.026625238,
0.009007741,
0.033112403,
-0.022340259,
0.032926675,
-0.0066098776,
-0.001159133,
0.048527714,
0.0056679784,
0.0046497984,
0.04271712,
0.020071741,
0.026572173,
-0.0099430075,
-0.0060792305,
0.03932098,
-0.0022784676,
-0.012085496,
0.03953324,
0.018678792,
0.008828647,
0.0052268775,
-0.027275281,
0.0014476727,
0.022658648,
-0.016781727,
-0.0063710865,
0.004434223,
0.0024177625,
0.011408921,
-0.020071741,
0.047625612,
-0.00488859,
-0.018241007,
0.03016731,
0.022035137,
0.003208759,
-0.03534112,
-0.009525122,
-0.022088202,
0.018784922,
0.017126648,
0.006586662,
0.0142213525,
0.022340259,
-0.010811943,
0.030565295,
0.015746964,
0.05229531,
-0.026466044,
-0.014765266,
0.0061488776,
0.020867713,
0.016927654,
-0.007163741,
-0.03173272,
-0.0066861585,
0.03512886,
-0.0070708776,
-0.017166447,
-0.004699547,
0.0057210433,
0.00024376619,
0.0040229713,
0.0079995105,
-0.022128,
-0.044574387,
-0.010685913,
0.0071106763,
0.008669454,
-0.010022604,
0.012556446,
-0.0077209207,
-0.03531459,
-0.017524634,
0.015375511,
0.012012532,
0.0056679784,
-0.0008382572,
-0.022632115,
0.010884906,
0.030140776,
-0.023321956,
-0.01899718,
-0.01621128,
0.00092946226,
-0.005488885,
0.006812187,
-0.030883683,
0.017683828,
0.0035254892,
0.0074025323,
-0.049217556,
0.010825208,
0.022605583,
-0.010301194,
-0.033138935,
0.0022486188,
0.017060317,
0.014818331,
-0.029212143,
0.010666015,
-0.01614495,
0.0013514928,
-0.02474144,
0.020390129,
-0.028681496,
0.021305496,
-0.0040495037,
0.0097506475,
0.002334849,
-0.013690705,
-0.031706188,
-0.018386936,
-0.020934043,
0.010539985,
0.020058475,
-0.018771654,
-0.01704705,
-0.010400691,
-0.011773741,
0.0062384247,
-0.026174188,
0.0100889355,
-0.00061356113,
-0.0015438525,
-0.0032618237,
0.03165312,
-0.008841914,
-0.033775713,
-0.018957382,
-0.009783813,
-0.0006496286,
-0.00062558363,
0.005475619,
-0.008676087,
0.013690705,
-0.018877784,
-0.019328834,
0.014128489,
0.009611352,
0.0007843633,
-0.024622044,
0.015441841,
-0.02984892,
-0.007163741,
0.0040893024,
-0.002480777,
-0.015441841,
-0.012682475,
-0.009127136,
0.0038007626,
-0.0025388165,
-0.014433611,
-0.0022834425,
-0.0064009354,
-0.0036017697,
0.015800029,
0.011554849,
-0.0017295792,
-0.024383252,
0.014340748,
0.04481318,
-0.010838475,
-0.00060651347,
-0.024303654,
0.014765266,
0.0031042877,
0.0012868202,
0.037065726,
0.036508545,
-0.005422554,
0.020708518,
-0.004755928,
-0.024011798,
0.016927654,
-0.043300834,
0.015746964,
-0.027540604,
0.006762439,
-0.016290877,
-0.0025421332,
0.002590223,
0.0018290755,
-0.020045208,
0.0014277734,
0.003906892,
0.013219755,
0.018851252,
0.0029517266,
-0.0010281295,
-0.020827914,
-0.01520305,
-0.017524634,
0.017869554,
0.026558906,
-0.010831842,
-0.020403396,
0.011422187,
0.0076479567,
0.014486676,
-0.010221597,
0.0016773435,
0.003900259,
0.0100425035,
0.00986341,
0.0010770486,
0.021531021,
-0.016012289,
-0.008052575,
-0.00024314433,
0.05667315,
-0.012165094,
-0.0019965612,
0.019023713,
0.0022884172,
-0.010579784,
0.009014375,
0.027301813,
0.022592317,
0.00636777,
-0.010115468,
0.01756443,
-0.002202187,
0.0020463094,
-0.016781727,
-0.02476797,
0.0044309064,
-0.023892403,
0.010294561,
0.015627569,
0.047201093,
0.022048403,
0.009286331,
-0.008490359,
-0.00075078325,
-0.019050244,
0.0114022875,
0.018386936,
0.0004676331,
-0.005611597,
0.009239899,
0.012808504,
-0.009438892,
0.015176518,
0.019713555,
-0.0139294965,
0.00080136064,
0.0067226402,
0.0015795054,
0.009976173,
-0.009054173,
-0.009710849,
-0.0033729281,
-0.021875942,
0.030034648,
0.03329813,
-0.018174676,
-0.02129223,
-0.0055220504,
-0.014181554,
-0.012642676,
0.025272086,
0.008357698,
0.0047658775,
0.02292397,
0.022446388,
0.009710849,
-0.016688863,
0.028336575,
-0.0072632376,
0.0022718345,
0.0030064497,
-0.0016707104,
-0.008868446,
-0.009385827,
-0.024953699,
0.0146591365,
0.0060692807,
-0.009996072,
-0.0076943883,
-0.008032676,
-0.02369341,
0.0056447624,
0.0044972375,
0.001983295,
-0.02647931,
-0.009856777,
0.016542936,
-0.0077938847,
0.025590476,
0.026240518,
-0.022539252,
0.0025205757,
-0.04324777,
-0.01160128,
0.017033784,
0.05041151,
0.009147036,
-0.027805928,
0.010997669,
0.0075219283,
0.01927577,
0.013332518,
-0.021239165,
0.023481151,
-0.034385957,
0.00013432014,
-0.0041821655,
0.0249139,
-0.008649554,
-0.0012727248,
0.015945956,
0.002754392,
-0.016781727,
-0.028973352,
-0.0023215828,
0.00883528,
-0.014977525,
0.01631741,
0.008477094,
0.04391108,
-0.020244202,
0.011335957,
0.00037394065,
0.024263857,
-0.014990792,
-0.013823367,
-0.003233633,
-0.017246043,
0.018108346,
0.0008482068,
0.00067864836,
0.007979612,
0.02598846,
-0.020801382,
0.013995827,
0.018280806,
0.0034525252,
0.018466532,
0.018174676,
0.014725468,
-0.013412115,
-0.002953385,
0.014128489,
-0.020575857,
-0.019129843,
0.027129352,
-0.014274417,
-0.025510877,
-0.015402043,
0.027646733,
-0.013226389,
-0.011541583,
0.007017813,
-0.00977718,
-0.0032767481,
0.012231424,
-0.04332737,
0.016609266,
0.00197832,
0.00022801259,
0.0111568635,
-0.0032253417,
0.004112518,
-0.0358983,
-0.003585187,
-0.00030781698,
-0.027076287,
-0.010553252,
0.011806906,
0.032342963,
0.002135856,
-0.0036017697,
-0.014950993,
0.0026051474,
0.022101467,
-0.017803224,
-0.022446388,
0.0069183167,
-0.040037353,
0.012058964,
-0.0070642447,
0.015601036,
-0.0040461873,
-0.01951456,
0.038498476,
0.017299108,
-0.0071372087,
0.006533597,
0.0041291006,
0.0014667428,
0.0286019,
0.01721951,
0.014009094,
0.003790813,
-0.01833387,
-0.008881712,
-0.019143108,
-0.0069979136,
-0.027434476,
-0.005840439,
-0.025272086,
-0.008888345,
0.005452403,
-0.010858374,
-0.021172835,
0.008808748,
-0.008948043,
-0.002377964,
0.001055491,
0.025723137,
0.0175379,
0.0014667428,
0.018068546,
-0.014128489,
0.015601036,
-0.00041415376,
-0.0006517014,
0.022101467,
0.018678792,
-0.021385094,
-0.0010389083,
0.0059100864,
-0.03051223,
-0.020443194,
-0.013067194,
-0.010221597,
0.037861697,
0.02504656,
-0.018400202,
-0.029716259,
-0.003916842,
0.004719446,
0.0067491727,
-0.0035089066,
-0.01767056,
-0.03226337,
-0.0044375397,
0.0025106259,
-0.022711713,
0.020655453,
-0.034677815,
-0.0019269136,
0.029981583,
0.010015971,
0.0026134388,
-0.0059200358,
0.0019219388,
-0.017511368,
0.00784695,
-0.037198387,
-0.02564354,
-0.0024542445,
-0.0248741,
0.043513093,
0.027328346,
0.020350331,
-0.012171727,
0.02334849,
0.03144086,
0.013213122,
0.014619338,
0.006022849,
0.01144872,
-0.004954921,
0.015547971,
0.02519249,
0.017378705,
0.001771036,
-0.005071,
0.016397007,
0.013518245,
-0.014778532,
0.0027262014,
-0.009717482,
-0.034943137,
-0.03664121,
0.018214475,
-0.00793318,
0.0009742356,
-0.046192862,
0.004805676,
0.03934751,
-0.0035520217,
0.01252328,
0.012039064,
0.020456461,
-0.008357698,
0.033457324,
-0.0041224677,
0.010135367,
-0.019355368,
-0.024462849,
-0.017803224,
-0.009704215,
0.007369367,
-0.016728662,
0.0013432015,
-0.0014020702,
-0.01721951,
-0.009080705,
0.015402043,
-0.024688374,
-0.011236461,
-0.0066762087,
-0.0034094101,
-0.016808258,
-0.010022604,
-0.026213985,
-0.022990303,
0.01614495,
0.019474763,
-0.015640834,
0.012138561,
-0.02094731,
-0.0039102086,
0.021703482,
-0.0013738795,
0.034492087,
-0.0026515792,
0.021584086,
-0.00064879947,
-0.0068320865,
-0.022234129,
-0.0032120754,
-0.0036482015,
-0.000463902,
0.031122474,
0.024834301,
-0.019594159,
-0.0156939,
0.006702741,
0.005064367,
-0.00451382,
-0.015149985,
0.023852604,
-0.028469237,
-0.005863655,
-0.008430662,
-0.012390619,
-0.018665526,
0.001606867,
-0.012828403,
0.020708518,
0.00081918703,
-0.019925812,
-0.011024201,
0.00063967897,
0.001437723,
0.0014435269,
0.0017478202,
-0.020536058,
-0.028097784,
-0.019249238,
-0.0042982446,
-0.019740086,
-0.0042451797,
0.029450936,
0.0020645503,
0.006188676,
0.017763425,
0.0068519856,
-0.010984403,
-0.009525122,
-0.014698936,
0.03799436,
-0.022128,
-0.010778777,
-0.014844864,
0.011913036,
0.0046531153,
0.0021938956,
-0.0008996133,
-0.008443928,
0.00094770326,
-0.012921266,
0.006898417,
0.0051671797,
-0.009186834,
-0.01391623,
-0.0033132301,
-0.016410273,
-0.012397252,
-0.018386936,
0.020655453,
-0.024608778,
0.0018854568,
0.00097506476,
0.02984892,
0.023932202,
-0.019501295,
-0.0038670935,
-0.024038332,
0.045211166,
-0.022937238,
0.022910705,
0.00663641,
-0.015070388,
-0.010161899,
0.0175379,
-0.006006266,
-0.04303551,
0.0009244874,
-0.014128489,
-0.014208087,
-0.019925812,
-0.009478691,
0.0035918201,
0.015110187,
-0.032687884,
0.006958115,
0.0039997553,
0.021133035,
-0.009730748,
-0.0042186477,
0.031998042,
-0.015906159,
0.022884173,
0.0023282159,
-0.010035871,
-0.0046630646,
-0.0050610504,
0.012848302,
0.010652748,
-0.010022604,
-0.027673267,
-0.022804575,
0.026519109,
0.0047094966,
0.014990792,
0.012748806,
0.0019849532,
-0.0015148327,
0.011488518,
0.0027162519,
0.005402655,
-0.03666774,
-0.006440734,
-0.0136376405,
-0.014380547,
-0.011415554,
0.013233022,
0.019315569,
-0.020681987,
-0.054444432,
-0.0008548399,
-0.0067989207,
0.037384115,
-0.0008581565,
-0.022300461,
-0.007959712,
0.0003592235,
-0.063836895,
-0.01237072,
0.0033331295,
0.010646115,
0.004749295,
-0.000049437276,
-0.011236461,
0.005993,
-0.0003550778,
0.024144461,
0.018493066,
0.0035752375,
0.011249727,
0.008934777,
0.015800029,
0.01704705,
-0.049350217,
0.0026548957,
0.04322124,
0.009100605,
-0.031998042,
0.01826754,
-0.010792043,
0.020177871,
-0.0007640495,
-0.0062516904,
-0.01337895,
0.011913036,
0.039374042,
-0.016131684,
-0.023321956,
0.03512886,
0.0077938847,
0.001752795,
-0.000667455,
0.014128489,
0.026691569,
0.02268518,
-0.0038007626,
-0.016741928,
-0.0004547815,
-0.003578554,
0.025842533,
0.018015482,
0.010798676,
0.003906892,
-0.009233266,
-0.021756547,
-0.0027742914,
-0.007959712,
-0.011588015,
-0.018187942,
-0.0099430075,
-0.007024446,
-0.0008498651,
-0.011627813,
0.0057940073,
-0.0011574748,
-0.0018207842,
0.009259799,
-0.0396659,
-0.010639482,
0.0039632735,
0.019753352,
-0.01172731,
-0.014141755,
0.002560374,
-0.026744634,
-0.014009094,
-0.0016035504,
0.0027709748,
-0.009153669,
0.03197151,
-0.030459166,
-0.0010463705,
-0.0034193597,
-0.018081812,
-0.0021590719,
-0.020164605,
-0.003469108,
0.20164604,
-0.023547482,
0.008636287,
0.00008441648,
0.0029965,
-0.0077673527,
0.02693036,
-0.018042015,
-0.006052698,
0.022950504,
0.005024568,
-0.018493066,
0.0007283966,
0.0032352915,
-0.024887366,
-0.013624374,
-0.036455482,
0.013325885,
-0.034147166,
-0.003512223,
0.017179713,
-0.008967943,
-0.02828351,
-0.0033878526,
0.034492087,
0.0076479567,
-0.008185238,
0.012463583,
0.0026466043,
-0.017365439,
-0.034067567,
-0.012616144,
0.0023978634,
-0.0008291367,
0.010268029,
0.0020131439,
-0.015455108,
-0.024953699,
0.017073583,
-0.007117309,
-0.008324533,
0.0359779,
0.004032921,
-0.00066869875,
0.008536791,
0.0033895108,
-0.004626583,
0.005598331,
-0.030353036,
-0.008079108,
-0.025550677,
-0.0060460647,
-0.011913036,
0.003717849,
-0.010307827,
0.0027527339,
0.012582978,
-0.00046556024,
-0.0057707913,
0.021756547,
-0.008397496,
0.00036067446,
-0.047864404,
0.025073094,
-0.006513698,
0.03924138,
-0.035792172,
0.021517755,
0.013286087,
-0.015561237,
-0.005422554,
-0.01089154,
0.0007739991,
0.004003072,
0.006477216,
0.0034890072,
0.009193468,
-0.0009021007,
0.020323798,
0.016582733,
0.016781727,
-0.0136376405,
-0.025404748,
-0.006132295,
-0.018081812,
-0.03263482,
0.006689475,
-0.004563568,
-0.020323798,
0.015601036,
-0.0026366548,
0.0018340504,
-0.0017876187,
-0.015176518,
0.002633338,
0.01597249,
0.016649066,
0.0054689855,
0.004464072,
-0.01899718,
-0.023918936,
0.062457208,
0.0051970286,
-0.0051970286,
-0.0037709137,
0.0086296545,
-0.00029392896,
0.0031474028,
0.012762072,
-0.018174676,
0.024688374,
-0.009870043,
-0.011461985,
-0.008178605,
0.014486676,
0.019647224,
0.017657295,
-0.01582656,
0.02553741,
-0.0100889355,
0.0075749927,
-0.021889208,
-0.002165705,
0.022326993,
-0.0134452805,
-0.005014619,
-0.0026615288,
-0.0031258452,
-0.027434476,
-0.044998907,
0.0016748562,
-0.007442331,
-0.02369341,
0.0047094966,
-0.009916475,
0.011946201,
0.00027858993,
-0.011773741,
-0.04481318,
0.010692547,
-0.008278101,
-0.0016823184,
-0.0041291006,
0.03619016,
-0.00027734623,
-0.03833928,
0.0010795359,
-0.012529913,
0.01252328,
-0.013902964,
-0.009472057,
-0.01603882,
-0.005525367,
0.004301561,
0.019129843,
-0.030538762,
-0.02174328,
-0.04001082,
0.011554849,
0.016781727,
-0.030459166,
0.0074754963,
0.020284,
-0.00010519672,
0.0018655575,
-0.008967943,
-0.16651718,
0.009007741,
0.025776202,
-0.0054391366,
0.03016731,
0.011740576,
0.00988331,
0.02275151,
0.015362245,
0.008118906,
0.02984892,
0.0030644892,
-0.030432634,
-0.016927654,
-0.0041456833,
0.0026582123,
-0.011568115,
0.036933064,
0.019302303,
-0.004941655,
0.022499453,
-0.003233633,
0.016675597,
-0.026068058,
-0.002092741,
0.0023000252,
-0.0045105037,
-0.007077511,
0.005283259,
-0.0014974208,
-0.042080346,
0.0054822518,
0.020098273,
-0.017896086,
0.006278223,
0.009571554,
0.008264835,
-0.012980964,
-0.017750159,
0.0047526117,
0.020018676,
0.01798895,
0.021730015,
-0.00030139118,
-0.008815382,
0.013624374,
0.009292964,
-0.002366356,
0.01989928,
-0.00063760614,
0.012344187,
0.0108650075,
-0.0075617265,
0.027248748,
0.04001082,
-0.018254273,
0.005203662,
0.00791328,
0.0009783813,
-0.0078535825,
-0.026174188,
-0.01826754,
0.030326504,
-0.020310532,
-0.0076943883,
-0.04226607,
-0.028761094,
-0.02317603,
-0.019023713,
0.011276259,
-0.025749668,
0.0023149496,
0.00047094963,
-0.011408921,
0.011422187,
0.01299423,
-0.011335957,
0.00014572077,
-0.00442759,
-0.00004928181,
-0.01282177,
0.012344187,
-0.03520846,
0.00032792357,
0.0038803597,
-0.0034558417,
0.009120503,
0.024834301,
-0.0076081585,
0.0028555468,
0.00793318,
0.009405727,
-0.017100114,
-0.015999021,
0.0024011799,
0.007953079,
0.009273064,
-0.016794993,
0.02056259,
0.017630763,
0.015083655,
-0.015614302,
-0.020310532,
0.025869064,
0.03016731,
-0.008808748,
-0.012171727,
-0.015282648,
0.04205381,
-0.004931705,
-0.013584576,
0.005684561,
0.018771654,
0.040700663,
0.0014941043,
0.032236833,
0.0058371224,
-0.01134259,
0.006321338,
-0.0029998166,
0.058583483,
-0.0066496762,
-0.030804086,
0.03374918,
-0.01603882,
-0.024728173,
-0.12661248,
0.0050411513,
0.012874834,
0.0013150108,
-0.020854445,
0.020549323,
-0.011833439,
0.0041722157,
-0.0040992517,
0.0019053561,
-0.02358728,
-0.03512886,
-0.010845108,
-0.028363109,
0.0018058597,
0.0014941043,
-0.0011566457,
0.007316302,
-0.0075550936,
0.026797699,
0.0074688634,
0.004895223,
-0.0006890126,
-0.015375511,
0.014115223,
-0.0059100864,
-0.028363109,
0.011229827,
-0.0031109208,
-0.00015753598,
0.008695985,
-0.008443928,
0.0071239425,
-0.010599683,
-0.019434964,
-0.008152072,
0.0017677194,
-0.019368634,
0.021438159,
0.0011931277,
-0.010327727,
0.02828351,
-0.00009187871,
0.024263857,
0.01944823,
-0.02519249,
0.008775583,
0.011926302,
0.008284734,
-0.02703649,
-0.008722518,
-0.015959224,
-0.029901985,
-0.03857807,
0.00580064,
-0.018081812,
0.011468619,
-0.0021822879,
-0.010148633,
0.0036979497,
-0.0014236277,
-0.009598087,
-0.01061295,
0.004069403,
0.0063710865,
-0.0125697125,
-0.010128734,
-0.04491931,
0.026412979,
-0.045317296,
-0.0041622664,
0.0010588076,
-0.016436806,
-0.010831842,
-0.05922026,
0.01820121,
-0.0313878,
-0.016649066,
0.02553741,
-0.041337438,
-0.0046564317,
-0.011906403,
0.034916606,
-0.047307223,
0.042504862,
0.012967698,
0.004951604,
-0.0049582375,
-0.013538144,
-0.009432259,
-0.007090777,
0.017617496,
-0.03263482,
-0.0013092068,
-0.006659626,
0.027169151,
-0.012297755,
-0.006052698,
-0.0012412176,
0.016980719,
-0.015601036,
-0.010937971,
-0.047837872,
0.014950993,
0.0096047195,
-0.0072566043,
0.01134259,
-0.016848058,
0.011946201,
0.015242849,
0.0013697338,
0.029689727,
-0.019050244,
-0.013286087,
-0.001116018,
-0.012470216,
-0.015415309,
-0.0072632376,
0.024091396,
0.0041158344,
0.023706676,
0.018174676,
-0.008722518,
0.004384475,
0.022419857,
0.021584086,
-0.010493554,
0.010175166,
-0.0059299855,
0.03587177,
-0.017551165,
-0.022711713,
0.009744015,
-0.022565784,
0.010347626,
-0.00061729224,
0.00059532013,
-0.001364759,
-0.00451382,
0.0050842664,
0.014990792,
0.046856172,
-0.012304389,
-0.0396659,
0.020867713,
-0.015362245,
0.010732345,
0.005233511,
-0.031706188,
0.021371827,
-0.005943252,
0.013597841,
0.0048620575,
0.012430417,
-0.011568115,
-0.025975194,
-0.018148145,
0.010957871,
0.01224469,
-0.011209928,
0.011090532,
-0.024277123,
0.037224922,
0.024184259,
-0.007236705,
0.012238057,
0.00030346404,
-0.029106015,
-0.023733208,
-0.010367525,
0.020257467,
-0.050358444,
-0.021066705,
0.009962906,
0.005757525,
0.022419857,
0.021093238,
0.005233511,
-0.0010820234,
0.010195064,
-0.002517259,
0.007024446,
-0.008802115,
0.0024343454,
-0.022353524,
0.01966049,
0.029132547,
0.005137331,
-0.010281295,
0.025431281,
-0.0070310794,
-0.005677928,
-0.005362856,
0.029212143,
0.009326129,
0.017551165,
0.00442759,
0.038631137,
-0.005532,
-0.007117309,
0.0063379207,
0.030459166,
-0.008556691,
0.006792288,
-0.002565349,
-0.029716259,
-0.0062384247,
0.030883683,
-0.017962417,
-0.018108346,
-0.0058503887,
0.010493554,
0.0027975072,
0.023083165,
0.0031573526,
-0.0045834677,
-0.01732564,
0.008881712,
-0.008815382,
-0.014977525,
-0.006944849,
0.05128708,
0.021265699,
0.029318273,
-0.025311885,
-0.007455597,
0.031042878,
0.008364331,
0.018174676,
-0.032581754,
0.029238677,
-0.013757036,
0.01625108,
0.012642676,
-0.028469237,
-0.009491957,
0.0101884315,
-0.008795482,
0.034147166,
0.0062948056,
-0.0059830504,
0.07471517,
0.01050682,
-0.006042748,
0.0055518993,
0.008377597,
0.016542936,
0.021862676,
0.005266676,
0.0005750063,
-0.03016731,
-0.0039102086,
-0.0051837624,
0.018227741,
-0.013677439,
-0.026598705,
0.017272575,
-0.008642921,
-0.0027759497,
-0.00958482,
-0.0072168056,
0.013047295,
-0.002008169,
0.02139836,
0.0010869981,
-0.02292397,
-0.009982806,
0.043062042,
0.007714288,
0.0133457845,
-0.012556446,
-0.00534959,
-0.021000374,
-0.02111977,
-0.000515723,
-0.005767475,
-0.013849899,
-0.019395165,
-0.01513672,
0.023295425,
-0.0034193597,
0.018983914,
-0.0040561366,
-0.0074157985,
-0.03913525,
-0.008092375,
0.034677815,
0.012662576,
-0.01430095,
-0.010155266
] |
Cardiovascular disease is a leading cause of death worldwide. The limited capability of heart tissue to regenerate has prompted methodological developments for creating de novo cardiomyocytes, both in vitro and in vivo. Beyond uses in cell replacement therapy, patient-specific cardiomyocytes may find applications in drug testing, drug discovery, and disease modeling. Recently, approaches for generating cardiomyocytes have expanded to encompass three major sources of starting cells: human pluripotent stem cells (hPSCs), adult heart-derived cardiac progenitor cells (CPCs), and reprogrammed fibroblasts. We discuss state-of-the-art methods for generating de | [
-0.021365216,
0.020050434,
-0.008953669,
-0.027610434,
-0.022811478,
0.01928786,
-0.02340313,
0.013805217,
-0.03681391,
0.0035729217,
0.008749878,
0.0091969045,
-0.011688417,
-0.003120965,
-0.00053864997,
0.020155616,
0.034026574,
-0.0012638348,
0.01881454,
0.008736731,
-0.03010852,
0.022850921,
-0.009124591,
0.0055549564,
-0.0073364866,
0.028136346,
0.009321809,
-0.014554643,
0.0013443652,
-0.01686866,
-0.0062156348,
-0.0033477652,
-0.01372633,
-0.028530782,
-0.005055339,
0.0007005326,
-0.0054464866,
-0.008730156,
0.008217391,
0.010761496,
0.004746365,
0.017026434,
0.00076586084,
-0.009966052,
-0.010051513,
-0.0054004695,
-0.021128556,
-0.011773878,
-0.0026640783,
0.01994525,
0.03513099,
0.0044998433,
0.012358956,
0.018051965,
-0.00074285216,
-0.026953043,
-0.022956103,
0.02654546,
0.021194296,
-0.027925981,
-0.010169843,
-0.006968348,
-0.017789008,
0.016553113,
-0.010459095,
0.008223965,
-0.009321809,
0.019511374,
0.012799408,
-0.014094469,
0.021378364,
-0.00031801304,
-0.002670652,
0.01112306,
0.007014365,
-0.024454955,
-0.023587199,
-0.010044939,
-0.008230539,
0.011681844,
-0.0057620346,
-0.031475894,
-0.0055582435,
0.046964034,
0.006021704,
-0.01675033,
-0.027163409,
-0.009288939,
0.026098434,
-0.009722817,
0.024468103,
0.03218588,
-0.005199965,
0.006508174,
-0.030923687,
-0.0068171476,
-0.000055005163,
0.030292591,
-0.008348869,
-0.023271652,
-0.015277773,
0.0011035956,
-0.011583234,
-0.022509078,
-0.028294122,
0.014765008,
-0.006721826,
-0.012944034,
0.034263235,
-0.0035663478,
-0.016132383,
0.036735024,
-0.0035301913,
-0.01342393,
0.031581078,
-0.019918956,
0.0250992,
0.010945565,
-0.0035367652,
0.0044998433,
0.021943722,
0.0017404434,
0.035157286,
-0.040442713,
0.0190512,
0.001429826,
-0.018301774,
0.014778156,
0.015067408,
0.010531409,
0.0029533303,
-0.0059822607,
-0.013739478,
0.03131812,
-0.022048904,
0.0073364866,
-0.011399165,
0.0043585044,
-0.022417042,
-0.045675546,
-0.013345043,
0.0096307825,
-0.005058626,
-0.011287408,
-0.03229106,
0.025743444,
0.021194296,
0.0081648,
0.015987756,
0.017512904,
-0.00021200869,
-0.022877216,
0.03210699,
-0.020655233,
0.00088336953,
0.018249182,
-0.011090191,
0.012766539,
0.004746365,
0.0038851826,
0.0051079304,
-0.01266793,
0.005196678,
0.005867217,
0.016553113,
0.004141565,
0.0040561045,
0.014765008,
0.015251478,
0.0014396869,
-0.0070669563,
0.037103165,
-0.01807826,
0.033763617,
-0.010945565,
0.0016122521,
0.0065509044,
0.0214704,
-0.040311232,
-0.010800939,
-0.0077506434,
0.011096765,
0.011714713,
0.023981635,
-0.0019146521,
0.008605252,
0.029845564,
-0.018472696,
0.012345809,
-0.02703193,
-0.020352835,
0.010584,
-0.012339234,
-0.005186817,
-0.6386688,
-0.022693148,
-0.0020773564,
-0.0160272,
0.010978434,
0.023153322,
0.02879374,
-0.0145152,
-0.019498225,
0.011800174,
-0.007165565,
-0.0063898433,
0.016000904,
-0.0092823645,
-0.011885635,
-0.015382956,
0.004167861,
-0.011353147,
-0.005735739,
0.004910713,
-0.017249947,
-0.0053248694,
-0.038312763,
0.022272417,
-0.012582469,
0.016710887,
0.011787026,
0.003845739,
-0.0007732565,
0.026440278,
0.017670678,
0.024520695,
-0.011550365,
-0.023376834,
0.044834085,
0.014791304,
0.0027068087,
0.022272417,
-0.00041436194,
0.023297947,
-0.017710121,
0.022351304,
0.017946782,
-0.0011931652,
-0.021601878,
0.020905042,
0.017210504,
-0.0021414522,
-0.01710532,
0.015198886,
0.016671443,
-0.0055352347,
-0.020944487,
0.010307895,
0.0048679826,
-0.00066232175,
0.02992445,
-0.008855061,
0.012635061,
-0.0011849478,
-0.005591113,
0.016579408,
-0.0042697564,
-0.028294122,
-0.008421183,
0.029530017,
-0.013831513,
0.0032886,
-0.00066355435,
-0.02745266,
0.0057160174,
0.011898782,
-0.0039542085,
-0.025191234,
0.007993878,
0.025296416,
0.015041113,
-0.013686887,
-0.0017437304,
0.003120965,
0.012845426,
-0.0034578783,
-0.007717774,
0.011655548,
0.017499756,
0.008256835,
-0.02461273,
0.030213704,
-0.0009565043,
0.031765148,
0.010662886,
-0.0006232891,
0.016894955,
-0.051802434,
-0.0020954348,
0.022206677,
-0.0065114605,
-0.0069026086,
0.006094017,
-0.0043552173,
-0.009729391,
0.0008710435,
0.010952139,
0.028820034,
0.00072806084,
0.00077161303,
-0.043624487,
-0.007717774,
0.04964619,
-0.05785043,
-0.0044801217,
-0.024034226,
-0.0005222152,
0.0038654609,
-0.0059888344,
-0.020418573,
0.007776939,
-0.0061236,
0.0065246085,
-0.035709493,
0.015816834,
-0.02521753,
0.0038227304,
-0.0096307825,
0.020997077,
0.006238643,
-0.0073364866,
0.003934487,
0.014909634,
-0.017263096,
0.00024302934,
-0.030949982,
0.020852452,
-0.023574052,
0.016526816,
-0.010222434,
0.007540278,
0.008237113,
0.00004291019,
-0.008348869,
-0.012326087,
-0.02049746,
0.008033321,
0.019182678,
-0.014672973,
0.0073364866,
-0.0077374955,
-0.015343512,
-0.0030782346,
-0.0062222085,
-0.005272278,
-0.00858553,
0.008486922,
0.013660591,
0.020208208,
-0.004812104,
-0.003540052,
-0.018577877,
-0.012003965,
-0.015067408,
0.004519565,
0.0076060174,
-0.00994633,
0.021246886,
-0.00940727,
-0.0160272,
-0.021930574,
0.0018472695,
-0.0051802434,
-0.020826155,
0.0008866565,
-0.013318747,
0.015014817,
0.009611061,
-0.007329913,
-0.0019310869,
-0.009893739,
-0.0024701478,
-0.026571756,
-0.006120313,
0.008855061,
-0.05280167,
-0.00015510326,
-0.000045555164,
-0.001429826,
0.01145833,
0.02454699,
0.014160208,
0.0046609044,
0.041389354,
0.005587826,
0.010044939,
-0.029950747,
0.008986539,
0.0156064695,
-0.0077111996,
-0.016671443,
0.0038293041,
0.008316,
0.015593321,
0.024218295,
-0.014646678,
0.016776625,
-0.027215999,
0.013003199,
-0.025072904,
-0.001118387,
-0.0018028956,
0.0066232174,
0.019156381,
-0.0055681043,
0.0071918606,
-0.018012522,
-0.01372633,
0.008460626,
0.027768208,
0.008033321,
-0.02763673,
-0.001092913,
-0.000034076493,
0.00021467934,
-0.008480348,
0.013213565,
-0.012727096,
-0.0018571304,
0.009657078,
-0.016724035,
0.029819269,
0.0041875825,
-0.025191234,
-0.012852,
0.008217391,
0.023442574,
0.0016434782,
-0.011425461,
0.01873565,
0.006698817,
-0.013338469,
0.027242295,
0.016461078,
0.016369043,
0.002478365,
0.007020939,
-0.00023850978,
-0.017210504,
0.009788556,
0.019853218,
0.0015325435,
-0.017802157,
0.023705529,
-0.0374713,
0.008835339,
-0.004680626,
-0.008276557,
-0.007007791,
-0.019432487,
-0.0049271476,
0.01698699,
0.03397398,
-0.00016691575,
0.016106086,
-0.0039805043,
0.0019376609,
-0.019182678,
0.007402226,
-0.0015111782,
0.019366747,
-0.00925607,
-0.019577112,
-0.0011734434,
-0.0131544,
0.01947193,
0.00009208614,
-0.05516828,
0.007553426,
0.004900852,
0.03194922,
-0.00865127,
0.014646678,
-0.0052328347,
-0.009762261,
-0.021799095,
0.0024750782,
0.024034226,
-0.0052459827,
-0.007967582,
-0.014015582,
-0.0033822781,
-0.014870191,
0.034421008,
-0.0030157825,
-0.0053774607,
0.014870191,
-0.012155165,
-0.007776939,
-0.0111887995,
-0.00035889455,
0.0018669913,
0.02291666,
-0.0030009912,
0.0101501215,
-0.0033214695,
-0.008138504,
-0.026926747,
0.03260661,
0.011833043,
0.001429826,
0.016960695,
0.008171374,
-0.0063306782,
-0.009085148,
-0.018406956,
-0.0013944913,
-0.021667616,
0.006340539,
0.007717774,
0.0016500521,
0.011280835,
0.0124312695,
0.015396104,
0.003213,
-0.018459547,
0.0014552999,
-0.037418712,
0.045465183,
0.011208521,
-0.018801391,
0.008841913,
-0.019669147,
0.007612591,
0.0069749216,
-0.0244944,
0.04178379,
-0.010938991,
0.010505113,
-0.017867895,
0.007901844,
-0.027137112,
0.004131704,
0.024192,
-0.024454955,
0.007389078,
-0.029714087,
-0.009459861,
-0.0015111782,
-0.011859339,
0.029766677,
0.024415512,
0.028977808,
0.00084803475,
0.018683061,
0.027005633,
-0.0080990605,
0.023666086,
-0.010090956,
0.016474226,
-0.008191096,
0.015290922,
-0.008677565,
0.0086183995,
0.008598678,
0.02805746,
0.022535373,
0.031397007,
0.012102573,
0.023048138,
-0.010952139,
0.00005942201,
0.018288625,
-0.019537669,
-0.011747582,
0.0007449065,
0.011931652,
-0.043203756,
0.029293356,
-0.019524522,
-0.030055929,
-0.034289528,
0.025572522,
-0.011517495,
-0.020458017,
-0.009124591,
-0.0031439739,
0.021983165,
-0.0003845739,
-0.044097807,
0.003858887,
0.003168626,
0.0066067823,
-0.010991583,
-0.018183444,
0.0034085738,
-0.037339825,
-0.004992887,
0.006238643,
-0.006264939,
-0.012687651,
0.027715616,
-0.012188034,
0.011024452,
0.02365294,
-0.023376834,
0.005633843,
0.028530782,
0.010386783,
-0.0035860694,
-0.030450365,
-0.013949843,
-0.0023008694,
-0.0026591478,
-0.010781217,
-0.02365294,
0.015514434,
0.023587199,
0.022403896,
-0.014659826,
-0.007698052,
0.0029270346,
-0.010018643,
0.013765774,
0.033001043,
0.00055755,
-0.00024118043,
-0.005006035,
-0.0022400608,
-0.023205912,
-0.01512,
-0.029530017,
0.0007633956,
-0.012260348,
-0.0031965652,
0.009216626,
0.0076586083,
-0.012858573,
0.011701565,
-0.00061055215,
0.038365357,
0.008158226,
0.016960695,
0.021023374,
0.008447478,
0.022772035,
0.008697287,
-0.016198121,
0.0122866435,
-0.002828426,
0.04099492,
-0.0150279645,
-0.013193843,
0.0011907,
0.0036583825,
-0.02158873,
-0.04280932,
0.00940727,
-0.012076278,
0.02135207,
-0.010051513,
-0.02061579,
-0.02037913,
-0.026795268,
0.01115593,
0.022101495,
0.0024290609,
-0.007744069,
-0.0063701216,
0.004434104,
0.009683373,
-0.0011060608,
0.05611492,
-0.043256346,
-0.0075797215,
0.016960695,
0.0020954348,
-0.004079113,
-0.036182817,
0.0048811305,
-0.011057321,
0.0029188173,
-0.02763673,
-0.021299478,
-0.007020939,
-0.033842504,
0.030292591,
0.041100103,
0.034315825,
0.0057817562,
0.0073496345,
-0.0019113652,
0.01463353,
0.002006687,
-0.016894955,
0.007822956,
-0.027321182,
0.02582233,
0.0012367173,
-0.007369356,
-0.0033264,
-0.039101634,
0.0110441735,
0.012654782,
-0.017499756,
-0.031607375,
-0.0005189282,
-0.020865599,
-0.031659964,
0.0020116174,
-0.014738712,
0.003484174,
-0.037813146,
0.0031965652,
0.030187408,
-0.0042730435,
-0.000058908423,
0.0041119824,
0.013515965,
-0.0058573564,
0.005351165,
0.008348869,
0.014738712,
-0.0055319476,
-0.030949982,
-0.012280069,
-0.002295939,
0.0029993476,
0.0018061826,
0.008868208,
0.026374537,
-0.023613496,
-0.011195374,
0.02726859,
-0.036971685,
-0.019379895,
0.004434104,
-0.04270414,
0.007165565,
-0.020550052,
-0.018222887,
-0.02377127,
-0.018485842,
0.016487373,
-0.032580312,
0.023205912,
-0.021115407,
-0.0040889736,
0.021181148,
-0.018406956,
-0.007612591,
-0.007533704,
0.018130852,
0.029056694,
-0.008710435,
-0.025493635,
-0.015632765,
-0.0034019998,
0.0007128587,
0.027189704,
0.0022022608,
-0.002756113,
-0.0193536,
0.0062353564,
0.01795993,
-0.040784556,
-0.019669147,
0.016684592,
0.007310191,
-0.00020173696,
-0.0062287822,
-0.005719304,
-0.042230815,
-0.016316451,
-0.007310191,
-0.0036550956,
0.012135443,
-0.02407367,
-0.0100054955,
0.00979513,
-0.0033346172,
-0.0023452435,
0.011787026,
-0.020865599,
-0.02575659,
-0.009400696,
-0.018406956,
0.015185739,
0.008059617,
0.0060052695,
0.006560765,
-0.0019573825,
0.026571756,
0.0021184434,
0.018157147,
0.021194296,
-0.0016147173,
0.044150397,
-0.0009901957,
0.014962225,
0.015356661,
-0.0053774607,
0.008309426,
-0.017328834,
-0.01838066,
-0.011017878,
-0.03289586,
-0.023692382,
0.033001043,
0.010557704,
0.013134678,
-0.0021693911,
-0.011182226,
-0.027137112,
-0.03131812,
-0.01342393,
0.016921252,
-0.0163296,
-0.0108864,
-0.015751095,
0.016960695,
0.008874782,
-0.0027166696,
0.006968348,
0.0153172165,
0.031028869,
-0.009183756,
0.017999373,
0.00085543044,
0.002368252,
-0.023087582,
0.014291687,
-0.019103792,
-0.018669913,
-0.008598678,
-0.008795896,
-0.039811615,
-0.027189704,
-0.021628173,
0.018406956,
-0.015619617,
0.00798073,
0.009709669,
0.010268452,
-0.0015350087,
0.00008505,
-0.008638121,
0.015185739,
-0.021851687,
-0.010058086,
0.0060512866,
-0.017999373,
-0.019103792,
-0.019366747,
-0.01055113,
0.010932417,
-0.019248417,
-0.036787618,
-0.01565906,
0.021549286,
-0.017815303,
0.0000732375,
-0.027242295,
-0.012884869,
-0.016224418,
-0.0035367652,
0.030687025,
-0.010143547,
-0.0016771695,
0.019340452,
-0.00037964346,
0.0101501215,
-0.0131806955,
0.033763617,
-0.014436313,
-0.024704764,
-0.012418121,
0.004506417,
-0.020418573,
0.030502956,
0.01281913,
0.004766087,
-0.023587199,
0.009058852,
-0.053616833,
-0.017881043,
0.009288939,
0.023626642,
0.0075008348,
0.01584313,
0.0038621738,
0.018130852,
-0.012976904,
0.019011756,
0.01122167,
-0.026440278,
0.0399168,
-0.005706156,
0.006110452,
0.008368591,
-0.033369184,
-0.004798956,
0.03331659,
-0.00903913,
-0.00677113,
-0.007895269,
0.01182647,
0.025677703,
-0.013870956,
0.017473461,
-0.0062452173,
0.014528347,
0.024586434,
-0.03010852,
-0.014357425,
0.025861774,
-0.0056897216,
0.0017552348,
-0.0079544345,
-0.0027363913,
-0.0036288,
-0.010708904,
-0.01831492,
-0.0338688,
0.000032689808,
-0.0015670565,
0.0009934825,
-0.0026246347,
-0.006133461,
0.035209876,
0.012036835,
0.0041054087,
-0.008092486,
0.014265391,
0.0076651825,
-0.015501287,
-0.00048934564,
-0.006531182,
-0.0029582607,
-0.0046444694,
0.0141339125,
-0.030134816,
-0.013673739,
-0.008894504,
-0.008795896,
-0.005268991,
0.033264,
-0.008151652,
-0.014502052,
-0.008855061,
0.012470713,
-0.016684592,
-0.0094861565,
-0.017762713,
0.0040561045,
0.007343061,
-0.013036069,
0.017604938,
-0.0050323303,
-0.027741913,
0.0102816,
-0.0057620346,
0.004243461,
0.010840382,
0.18943387,
-0.006130174,
-0.0019984695,
0.0069814953,
0.011846191,
0.0083291475,
0.002969765,
-0.009768834,
0.0068368693,
0.011254539,
0.012930887,
-0.0076388866,
-0.0018390521,
-0.010445948,
0.01577739,
-0.025848625,
-0.019077495,
-0.011925078,
0.0036550956,
-0.014594086,
-0.028635964,
-0.017157912,
0.010537982,
-0.0022466348,
0.017526051,
-0.006567339,
-0.013594852,
0.0066823824,
0.028925216,
0.0050158957,
-0.022850921,
-0.0080136,
0.0021710347,
0.010610295,
0.023495164,
-0.0033691304,
0.00085871737,
-0.012036835,
0.017526051,
-0.0038030087,
0.02310073,
0.0063701216,
-0.0034578783,
-0.005420191,
-0.007533704,
0.052380938,
-0.01233266,
-0.0017240087,
0.0017716695,
-0.0199584,
-0.055799372,
0.013206991,
0.013634295,
0.009519026,
0.007836104,
0.0045261392,
0.0044834088,
0.022035755,
0.014265391,
0.020668382,
-0.0023485303,
-0.016277008,
-0.0044078087,
0.03946977,
-0.016710887,
0.014528347,
-0.0039673564,
-0.008125356,
0.020891896,
-0.0096768,
-0.011642399,
-0.0036025043,
-0.020168765,
-0.007343061,
-0.011504347,
-0.02466532,
0.02068153,
0.006790852,
0.00858553,
0.017460313,
0.0049402956,
-0.0065837735,
-0.013818365,
0.003786574,
-0.013805217,
-0.051592067,
0.016763479,
0.013660591,
-0.042414885,
-0.018722504,
-0.004595165,
0.014068173,
-0.022969251,
0.010307895,
0.040074572,
0.008421183,
0.015488138,
0.009952904,
0.028162643,
-0.0076520345,
-0.012128869,
0.08703861,
0.005061913,
-0.007987305,
0.011438608,
0.010537982,
-0.021904279,
0.012003965,
-0.011103339,
-0.0027922695,
0.0021365217,
-0.01977433,
-0.0053281565,
-0.009183756,
-0.002368252,
0.03973273,
0.035656903,
-0.01826233,
0.026887303,
-0.01735513,
0.004046243,
-0.0029664782,
-0.010202712,
0.044544835,
0.008151652,
-0.012352382,
-0.00092609995,
0.0032047825,
-0.011714713,
-0.018604174,
-0.018564729,
-0.0022762173,
0.0043585044,
0.00979513,
0.024389217,
0.028741147,
0.018709356,
0.006340539,
-0.016658295,
0.017946782,
-0.0050816345,
-0.018577877,
0.0089931125,
0.011833043,
0.026006399,
-0.009210052,
0.010340765,
0.015882574,
0.007165565,
-0.029135581,
-0.0022663565,
-0.0014133913,
-0.0058705043,
-0.0065246085,
0.010715478,
0.0060512866,
-0.0023123738,
-0.02321906,
0.00037122064,
-0.00782953,
-0.027426364,
0.022574816,
-0.00021550109,
-0.00089816086,
-0.02345572,
-0.018446399,
-0.16471596,
0.007369356,
0.022377599,
-0.03544654,
0.028425599,
0.00066314347,
0.0056930087,
-0.0025046607,
0.00026069675,
0.015212035,
0.047936972,
-0.013857808,
0.0039443476,
-0.025993252,
0.0077243475,
-0.013450226,
-0.0060151303,
0.055851962,
0.010695756,
0.007895269,
0.03289586,
-0.00013959293,
0.0020592783,
-0.035367653,
0.0169344,
-0.038365357,
0.011524069,
-0.005817913,
-0.007172139,
-0.030765912,
-0.024218295,
-0.005768609,
0.026400834,
0.0066067823,
-0.023468869,
0.0019672434,
0.007625739,
-0.0263088,
0.0030355044,
0.02061579,
0.003684678,
0.0142785385,
0.0018784956,
-0.031765148,
-0.022035755,
0.017131617,
-0.014699269,
-0.028294122,
0.018840834,
-0.015093704,
0.021483548,
0.010932417,
-0.0011800174,
0.031239234,
0.021417808,
0.01740772,
0.025414746,
0.0031094607,
-0.00843433,
-0.0034545911,
-0.015330365,
0.015882574,
0.010676035,
0.016198121,
0.026926747,
-0.0429408,
-0.002825139,
0.00018109076,
-0.037103165,
0.021641321,
-0.023744972,
-0.014620382,
0.009019408,
-0.013003199,
0.0387072,
0.010432799,
-0.009709669,
-0.008368591,
0.0006680739,
0.011241391,
-0.016553113,
0.020352835,
-0.013443652,
-0.011931652,
-0.013739478,
0.0021020086,
0.0035301913,
0.001042787,
0.0042500347,
-0.0032705218,
0.0050158957,
-0.037287235,
9.4692595e-8,
-0.0056962953,
0.0009540391,
0.021628173,
-0.010794365,
-0.01728939,
-0.002790626,
0.014225948,
0.015737947,
0.006856591,
-0.010051513,
0.0062320693,
0.042730432,
-0.0055187996,
-0.020550052,
0.012608765,
0.037523896,
-0.011931652,
0.0013460086,
-0.0012720522,
0.0075928695,
0.033395477,
-0.0070340866,
0.02629565,
-0.0125758955,
-0.0124312695,
0.00077941956,
-0.029004104,
0.06873684,
0.0059428173,
-0.012444417,
0.050487652,
0.0031784868,
0.0046346085,
-0.11570086,
-0.0053380174,
0.0050356174,
0.035209876,
-0.008486922,
0.02992445,
-0.011596383,
0.024415512,
-0.008230539,
0.030949982,
-0.009118017,
-0.02824153,
0.020050434,
0.0041021216,
0.029740382,
-0.01505426,
-0.022232974,
0.007573148,
-0.033816207,
0.025598817,
-0.008578956,
-0.015330365,
-0.013220139,
-0.030818503,
-0.007251026,
0.034973215,
-0.029792974,
0.035656903,
0.01024873,
0.021562435,
0.012523304,
0.013594852,
0.024994018,
0.00034759563,
-0.018709356,
-0.0052394085,
0.015567026,
-0.047621425,
0.034473598,
-0.02400793,
0.016881809,
0.027373774,
0.012220904,
0.0060512866,
0.0068500172,
-0.008881357,
-0.01656626,
0.007875548,
-0.010998156,
-0.024086816,
-0.024284035,
-0.030082226,
-0.027321182,
0.011971096,
0.011872486,
-0.040626783,
0.028977808,
-0.002236774,
-0.005831061,
-0.025651408,
-0.007546852,
-0.010077808,
-0.021062817,
-0.0060545737,
0.012792834,
-0.023179617,
-0.04443965,
-0.03108146,
0.015277773,
-0.021838538,
0.0058474955,
-0.018275477,
-0.02123374,
-0.007842678,
-0.029819269,
0.0062485044,
0.0017618086,
-0.0026197042,
0.002453713,
-0.015343512,
-0.014317982,
-0.011372869,
0.0193536,
-0.0020461304,
0.0054563475,
0.014502052,
0.020786712,
-0.011925078,
-0.0049238605,
-0.030213704,
-0.00006866657,
0.041389354,
-0.02200946,
-0.016632,
0.010656313,
-0.0009893739,
-0.0041974434,
0.002649287,
0.006636365,
0.010064661,
0.005055339,
-0.025677703,
-0.05406386,
0.016224418,
0.012411548,
0.004618174,
0.004726643,
-0.023547756,
0.017591791,
0.009058852,
0.025138643,
-0.008223965,
-0.017473461,
-0.010071235,
-0.008789321,
0.008263408,
-0.031581078,
0.00039772174,
0.041994154,
0.0080136,
-0.0029286782,
0.019038051,
0.010176417,
-0.0063898433,
-0.004207304,
0.016855512,
0.021693913,
-0.014041878,
-0.0020707825,
0.013778921,
0.004443965,
-0.029424833,
0.01115593,
-0.039811615,
-0.0033724173,
-0.0057850434,
-0.0072181565,
0.0022137652,
-0.017460313,
0.01001207,
0.009854295,
0.034131754,
0.0035860694,
-0.032501426,
-0.0044275303,
0.007619165,
-0.010452521,
0.009440139,
-0.03681391,
0.014344278,
0.012858573,
-0.010597148,
0.012930887,
0.0141339125,
-0.0205632,
-0.03768167,
-0.019511374,
0.007244452,
0.013686887,
-0.004871269,
0.006935478,
-0.021273183,
0.006928904,
0.007310191,
0.009473008,
0.014672973,
0.0010263522,
-0.013621148,
-0.005525374,
0.015185739,
0.009328382,
-0.017604938,
-0.011530643,
0.025125494,
-0.0016738826,
-0.0010436086,
-0.007316765,
-0.014778156,
-0.019616555,
0.027189704,
-0.011234817,
0.014488904,
0.007901844,
0.010623443,
-0.032764383,
0.029004104,
0.0070669563,
-0.0026279218,
-0.0044012344,
0.036288,
-0.0054826434,
-0.005729165,
-0.0027232433,
0.016763479,
-0.00020245598,
0.019235268,
0.0034513043,
0.026466573,
-0.019866364,
-0.0013131391,
0.0056206957,
0.010919269,
-0.008085913,
0.015856277,
-0.00053371955,
-0.019800626,
-0.019642852,
0.013594852,
-0.0138446605,
-0.020628938,
-0.025467338,
0.023823861,
0.007776939,
0.031659964,
0.0023057999,
0.0029368955,
-0.014554643,
0.0008784391,
0.01523833,
-0.010636591,
-0.017092174,
0.045491476,
-0.0035006085,
-0.0015613043,
-0.0042105913,
0.0178416,
0.005706156,
0.041257877,
0.013673739,
-0.007849252,
0.027347477,
0.0028777304,
0.025809182,
-0.00930866,
-0.02256167,
-0.0047069215,
0.014252243,
-0.037813146,
-0.0053741736,
0.0066034957,
-0.006642939,
0.072576,
0.013778921,
-0.0119119305,
-0.0057883305,
-0.0033642,
0.004897565,
0.0069223302,
0.029845564,
-0.046096276,
-0.023929043,
0.022377599,
-0.022890365,
0.02303499,
-0.033053633,
-0.0126613565,
0.02528327,
-0.0054629217,
0.024060521,
0.0055286605,
0.009131165,
0.010314469,
-0.00964393,
0.008401461,
0.008526365,
-0.021207443,
-0.0069946432,
0.030266294,
-0.020944487,
0.00092363474,
0.0058705043,
0.0069091823,
0.0095124515,
-0.02243019,
0.0061137388,
0.007020939,
0.020576347,
-0.009131165,
-0.02256167,
-0.013739478,
0.0010353912,
-0.011517495,
0.026874157,
-0.024349773,
-0.026979338,
-0.016198121,
-0.012096,
-0.004397948,
-0.008026748,
-0.009183756
] |
Expression of the receptor-type tyrosine phosphatase LAR was studied in cells of the murine hemopoietic system. The gene is expressed in all cells of the T cell lineage but not in cells of any other hemopoietic lineage and the level of expression in T cells is developmentally regulated. The CD4(-)8(-)44(+) early thymic immigrants and mature (CD4(+)8(-)/CD4(-)8(+)) thymocytes and T cells express low levels, whereas immature (CD4(-)8(-)44(-) and CD4(+)8(+)) | [
-0.028577115,
-0.0152654415,
-0.01895155,
-0.03454262,
-0.016672155,
0.00087105494,
-0.007977887,
0.004314571,
-0.03540228,
-0.008134188,
0.013702427,
-0.009560439,
-0.012178488,
0.006255314,
-0.022351108,
0.00016301752,
0.021843128,
-0.008726831,
-0.0038424106,
0.01317491,
-0.012165463,
-0.0009671152,
-0.019850284,
-0.030973738,
-0.0030381095,
0.014158307,
0.010595936,
-0.034490522,
-0.0044090035,
-0.019016678,
0.011253704,
0.0071833543,
-0.0006655023,
-0.0118268095,
-0.013363774,
-0.022559509,
0.009573464,
-0.012419453,
0.029879628,
0.009150147,
0.014223432,
0.017414587,
0.012556217,
0.010328921,
-0.004448079,
-0.0072680176,
0.018573822,
-0.012907895,
-0.018078867,
0.023406142,
0.019798184,
0.0026913157,
-0.016033923,
-0.015538969,
-0.021595651,
0.002499195,
0.013376799,
0.027613256,
-0.006121807,
-0.030426683,
-0.009645103,
-0.0075350325,
-0.030296432,
0.02143935,
0.02634982,
0.022351108,
-0.0030153154,
0.033761114,
0.013806628,
-0.0034646823,
0.030765336,
-0.00022366575,
0.0019423711,
-0.00019995596,
0.029462824,
0.0014474166,
0.0041094255,
0.0038489231,
-0.0023559188,
-0.004845345,
0.018704074,
-0.0068056257,
-0.030973738,
0.018691048,
0.015057039,
-0.0054933447,
0.041237533,
0.017974667,
0.01325306,
0.00096060266,
0.015174266,
0.0216738,
0.009143635,
0.03232835,
0.0003288843,
-0.0050146715,
0.008238389,
0.0432434,
-0.011077865,
-0.038398057,
-0.022025479,
0.002567577,
-0.007202892,
-0.015838547,
-0.025802765,
0.007202892,
-0.007567595,
-0.0022224113,
0.018586848,
-0.014158307,
-0.024786806,
0.040299725,
0.01932928,
-0.03529808,
0.044493813,
0.0038879986,
-0.005053747,
-0.00049169833,
-0.0022663712,
0.012139413,
0.021908253,
0.02378387,
0.004005225,
-0.0039303303,
0.03980477,
0.027873758,
-0.0025317578,
-0.010074931,
-0.046994638,
0.0022859087,
0.009404138,
0.006564661,
-0.009990267,
0.024982182,
-0.0029225114,
-0.005737566,
-0.030114079,
0.010700136,
-0.01210685,
-0.022325058,
-0.007378731,
0.023835972,
-0.013279111,
0.0021165821,
0.007144279,
0.021426324,
0.035949335,
0.003845667,
0.0022386927,
0.00915666,
0.003982431,
-0.009983756,
0.024018323,
-0.019303229,
0.004702069,
0.0018137482,
-0.013142347,
0.03516783,
-0.023927147,
0.005294712,
0.011976599,
-0.011129966,
0.009417162,
0.023953198,
0.028577115,
0.021270022,
0.02907207,
0.023158666,
-0.008954771,
-0.0026668934,
-0.005587777,
0.002474773,
0.0010786428,
0.003507014,
-0.014744437,
0.014366709,
0.008954771,
-0.010661062,
-0.033656914,
-0.008590068,
0.00022549741,
0.016502827,
0.02210363,
0.0076066707,
0.005148179,
0.0014579995,
0.015682247,
-0.0058287415,
-0.02627167,
-0.009202248,
-0.004930008,
0.011677021,
-0.0020840194,
-0.017297361,
-0.64354515,
-0.03110399,
0.012491091,
0.020097762,
0.0016322104,
0.033604812,
-0.010016318,
-0.024630504,
-0.042644247,
0.015356618,
-0.020931369,
-0.0006948088,
0.0034646823,
-0.027326703,
-0.027404854,
-0.033787165,
-0.018651973,
-0.013376799,
0.032953557,
0.011051815,
-0.01775324,
-0.016724255,
-0.006017606,
0.023028415,
0.010706649,
0.017154085,
0.026167467,
-0.02306749,
-0.014444859,
0.010706649,
0.00013076,
0.01986331,
-0.009879555,
-0.002103557,
0.043816507,
0.0034190943,
0.0005079797,
0.030244332,
0.02311959,
0.042826597,
-0.005763616,
0.007131254,
0.021426324,
0.005669184,
-0.03868461,
0.008127675,
-0.008179776,
0.007463394,
0.009632077,
0.0017339692,
-0.00969069,
-0.008804982,
-0.021908253,
-0.00859658,
0.0068968018,
-0.0025431549,
0.011286267,
-0.0034093254,
-0.008414228,
0.0036405213,
-0.009163173,
0.024122523,
0.0020693662,
0.00323023,
-0.0012072659,
0.0020514566,
0.0077238968,
-0.004695556,
-0.002381969,
0.019850284,
-0.0004741958,
0.031468693,
-0.0069489023,
0.02912417,
-0.0085184295,
0.030009879,
0.010127031,
-0.0061901887,
0.011051815,
0.007215917,
-0.002463376,
0.0046401992,
-0.0051416666,
0.013324698,
0.027769558,
0.0006423013,
-0.017388536,
0.028394764,
0.0021312353,
0.020553641,
0.013441925,
0.005239355,
-0.018586848,
-0.019120878,
-0.027248554,
0.014197382,
-0.0013741503,
-0.0010029343,
-0.003220461,
-0.026532171,
-0.022090605,
0.007938812,
0.030530883,
-0.009065485,
0.01447091,
0.006112038,
-0.05170973,
-0.0047574253,
0.028420813,
-0.039700568,
-0.0017763008,
0.00075708516,
-0.0032286018,
-0.016971733,
-0.009514851,
-0.013181423,
0.013780578,
0.013624277,
0.0065255854,
-0.03639219,
0.002149145,
-0.006620018,
0.026050242,
-0.006134832,
0.007261505,
0.026779648,
-0.004278752,
-0.0049104705,
0.011891935,
0.0010916679,
0.010068418,
0.002881808,
0.019524656,
-0.01988936,
0.0376426,
-0.0016281401,
0.03334431,
0.0073852437,
0.021934304,
-0.031885497,
-0.017388536,
0.0010525925,
-0.006125063,
-0.0026782905,
0.000050217946,
-0.015630145,
0.019368354,
0.0028427327,
0.0023770847,
0.0032399988,
-0.0037479785,
0.0060110935,
-0.0008865223,
0.015213341,
0.010713162,
-0.0017958386,
-0.034151867,
-0.0032693055,
0.0067926007,
-0.007118229,
-0.015747372,
-0.0004672762,
-0.007463394,
0.003949868,
0.009573464,
0.004962571,
-0.0059394552,
0.03357876,
0.0018218888,
-0.037382096,
-0.001719316,
-0.008349103,
-0.008863594,
0.0119049605,
-0.0070010023,
0.009032922,
0.012758106,
-0.01655493,
0.0068121385,
-0.016763331,
-0.002381969,
-0.0030136874,
0.004519717,
-0.0028785518,
0.011423031,
0.021361198,
0.025125459,
0.00963859,
0.010849926,
0.029931728,
-0.025242684,
0.011019252,
-0.027613256,
0.021608675,
0.01559107,
-0.033995565,
0.021100696,
0.02792586,
-0.00248617,
0.031755246,
-0.020762043,
-0.022325058,
0.009599514,
-0.012543191,
-0.008212339,
-0.021556575,
-0.010543835,
-0.016059974,
0.01162492,
0.017154085,
0.0127971815,
-0.0025757176,
-0.002813426,
-0.004203858,
0.0013505422,
0.012185001,
0.010517785,
0.0019407431,
0.007873686,
-0.01932928,
-0.003241627,
0.022494383,
0.016646104,
-0.010328921,
-0.0012837885,
0.010140057,
0.018456597,
0.005483576,
-0.016437702,
0.0059134047,
-0.0214654,
-0.023862021,
0.012119875,
0.018678024,
-0.005102591,
0.008453304,
0.007170329,
-0.005008159,
0.009137122,
0.0162293,
0.013213986,
0.012914407,
-0.0038619484,
0.0065125604,
-0.02248136,
-0.020241039,
-0.007111716,
0.010420097,
-0.015734347,
0.012289202,
0.0072940676,
0.017245261,
-0.0040019685,
0.016216276,
-0.01615115,
0.0137154525,
0.012679955,
0.013858729,
0.035245977,
0.011787735,
0.008140701,
0.0111169405,
0.011006228,
0.0012520398,
-0.0040149936,
0.02266371,
-0.022194806,
-0.01833937,
-0.0011128337,
-0.008297002,
-0.015903672,
0.0030218281,
0.030791385,
-0.0323544,
0.00362424,
0.007828098,
0.008550992,
-0.008629142,
0.016620055,
-0.0015377783,
-0.020488515,
-0.04636943,
0.02423975,
0.02899392,
-0.019394405,
-0.008980821,
-0.013428899,
0.0007131254,
0.0020026125,
0.0023884815,
0.008056037,
-0.006131576,
0.03555858,
0.013415875,
-0.018625923,
-0.016502827,
0.026636373,
0.0013399593,
0.017414587,
-0.0011283011,
-0.0069293645,
0.0048355763,
-0.0019407431,
-0.0025936272,
0.03881486,
-0.0046662497,
-0.00043593452,
-0.016867531,
-0.005122129,
-0.03003593,
0.009671153,
-0.018326346,
-0.002254974,
-0.022598585,
0.00070905505,
-0.009677665,
0.00043512046,
0.024200674,
0.018547771,
0.0006313113,
-0.013233523,
-0.019485582,
-0.008961284,
-0.011188579,
0.009019896,
0.013949905,
-0.0152393915,
0.007215917,
-0.02301539,
-0.0062781083,
-0.0127190305,
-0.011533745,
0.030921638,
0.0119049605,
0.0016558185,
0.025398986,
0.008427253,
-0.011449081,
0.014431834,
0.022181781,
-0.0036274963,
-0.0017974667,
0.02434395,
0.010367996,
0.022194806,
-0.005239355,
0.0068968018,
0.01975911,
0.022285981,
-0.004887677,
0.02800401,
0.011188579,
0.012790669,
-0.013702427,
0.0041647824,
0.017557863,
0.006694912,
0.0051123598,
0.0035721394,
-0.024630504,
-0.0014254367,
0.0053924,
-0.00073022087,
-0.0050570033,
0.016984757,
0.015630145,
0.024838906,
0.0040149936,
-0.0002997813,
0.004112682,
0.005398913,
0.0118007595,
0.0017583914,
-0.0040377877,
0.02113977,
-0.01042661,
-0.0026913157,
-0.018000716,
0.0013578689,
0.02573764,
-0.01665913,
-0.008642168,
-0.0001532487,
-0.004887677,
0.0006170651,
-0.0153696425,
-0.0014864919,
-0.0126929805,
-0.00941065,
0.008134188,
0.0071963794,
-0.017297361,
-0.020644818,
-0.019042727,
0.006333465,
-0.035115726,
-0.010153082,
0.021699851,
0.015799472,
0.018873401,
0.013481,
0.010348459,
0.006252058,
0.030687185,
-0.01833937,
-0.0028883205,
-0.015825521,
-0.017141059,
0.0046760184,
-0.007378731,
0.011917986,
-0.019824235,
-0.012139413,
0.008082087,
0.02248136,
-0.014132257,
0.02487798,
-0.006528842,
-0.020644818,
0.0026668934,
0.030713236,
0.0154217435,
-0.014249482,
0.0061543696,
-0.029202322,
-0.013598226,
-0.033995565,
0.0048225513,
-0.020254062,
-0.016099049,
0.0060143494,
0.021725902,
-0.018078867,
-0.011677021,
0.0152393915,
-0.00443831,
-0.010739212,
0.017740214,
0.02487798,
0.028863668,
0.0060990127,
-0.00054054253,
0.025802765,
-0.0110127395,
-0.015356618,
-0.020345239,
0.027613256,
0.014106206,
-0.01447091,
0.008759394,
-0.0010680599,
-0.007469907,
-0.0069489023,
-0.013871754,
-0.014093181,
0.0067339875,
0.005848279,
-0.0056984904,
-0.022911187,
-0.002963215,
-0.017961642,
-0.008857083,
0.015799472,
-0.015786447,
-0.013376799,
0.025242684,
0.0012870447,
-0.0032839586,
0.010947614,
-0.031468693,
-0.016489804,
0.017675089,
-0.010856438,
0.0067209625,
-0.004451335,
0.019225078,
-0.01831332,
0.006343234,
-0.020280113,
-0.041315682,
0.012647392,
-0.017180135,
0.02581579,
0.024330925,
0.02698805,
-0.018938527,
0.03675689,
0.026675448,
-0.0035819083,
0.013494025,
0.0009866529,
0.018990627,
-0.0063009025,
0.021348173,
0.018625923,
-0.00485837,
0.018469622,
-0.009983756,
0.0065907114,
0.017115008,
-0.011787735,
0.0077564595,
0.031807344,
-0.024435127,
-0.04733329,
0.01449696,
-0.005555214,
0.0023998786,
-0.0269099,
-0.011488156,
0.026427971,
-0.012634368,
0.0057929223,
-0.015356618,
0.022025479,
-0.014509985,
0.017336436,
0.00027169587,
0.00581246,
-0.0086226305,
-0.020097762,
0.0012357583,
-0.0102247195,
0.0015508034,
-0.0047476566,
-0.0017730446,
-0.002404763,
-0.012706006,
0.0009899092,
-0.007144279,
-0.0049202396,
0.0072680176,
-0.037877053,
0.00022732906,
-0.012217564,
-0.027639307,
-0.022468334,
-0.034751024,
-0.0018805019,
0.034803122,
-0.016580978,
0.014366709,
-0.0014913763,
-0.007235455,
0.023510342,
-0.013272598,
0.034594722,
-0.021804053,
0.009508339,
0.02324984,
0.0071898666,
-0.035089675,
-0.021322124,
0.010283333,
-0.009091535,
0.028681315,
0.006020862,
-0.0076652835,
-0.0010892258,
0.0119570615,
0.034047667,
-0.017310387,
-0.019654907,
-0.002915999,
-0.031051889,
0.006392078,
-0.008844057,
-0.007463394,
-0.03756445,
0.0031911547,
-0.015578045,
0.014210407,
0.0031699887,
0.0058710733,
-0.014900738,
0.029801477,
-0.010765263,
0.002264743,
0.0061901887,
-0.020384314,
-0.008414228,
-0.02477378,
-0.013122809,
-0.01836542,
0.0023070746,
0.020188937,
-0.0016655873,
0.020032637,
0.0042233956,
-0.0033604812,
0.0012495975,
-0.012504116,
-0.01788349,
0.040429976,
-0.025607388,
-0.0052588927,
-0.0027157378,
0.019016678,
-0.010127031,
-0.0029583306,
-0.014718386,
-0.0093845995,
-0.03566278,
-0.014314608,
0.03735605,
0.004382953,
-0.028707366,
0.015760396,
-0.039414015,
-0.011383955,
-0.026584271,
-0.026805699,
0.010967152,
-0.050954275,
0.0021410042,
0.009475775,
-0.0059329425,
0.024083449,
0.016802406,
0.012888357,
-0.013103272,
0.040898878,
-0.0053533246,
0.02520361,
0.0023754565,
0.014861663,
-0.03321406,
0.020840194,
-0.008883133,
-0.026962,
0.007567595,
-0.028472915,
-0.021178847,
-0.033005655,
0.010140057,
0.0012121503,
0.012582267,
-0.0060827313,
0.018560797,
-0.0027255067,
0.028472915,
0.021895228,
0.032562803,
0.0031325417,
-0.037538398,
-0.011611896,
-0.012334789,
-0.0063855657,
-0.0012699493,
0.0069749523,
-0.015604095,
0.014809563,
-0.005109104,
0.0017697883,
-0.018300295,
0.009931655,
-0.034620773,
-0.009039434,
-0.028134262,
0.004207114,
-0.0073852437,
0.017948616,
0.0038554359,
-0.021178847,
0.002393366,
0.0041517573,
-0.0102247195,
0.011149503,
0.0031195164,
0.017740214,
0.02149145,
-0.01895155,
-0.026636373,
-0.0035949333,
-0.036157735,
0.035845134,
0.0045848424,
-0.0107327,
-0.0075024697,
0.0036926218,
-0.034985475,
-0.016424678,
-0.012419453,
0.0055487016,
-0.017023833,
-0.001847939,
-0.015122166,
-0.0041940887,
0.0026099086,
0.029540975,
0.0012658789,
-0.04626523,
0.007261505,
0.003891255,
0.021595651,
0.0021784515,
-0.031051889,
-0.04407701,
0.03021828,
-0.00836864,
0.006922852,
0.020827169,
-0.059134047,
0.023588493,
-0.019199029,
0.024044374,
-0.007391756,
0.009267374,
0.019225078,
-0.024669578,
0.011605383,
0.0056301085,
-0.005626852,
-0.008772419,
0.0033735062,
0.0003286808,
0.01813097,
-0.0085184295,
-0.007821585,
-0.031729195,
0.008401203,
-0.00020880897,
0.022806987,
0.016385602,
-0.023106564,
0.008485867,
0.010074931,
0.0048909327,
-0.0032106924,
-0.020579692,
-0.013415875,
0.02459143,
-0.017245261,
0.008791957,
-0.00005820601,
0.004190833,
-0.008915695,
-0.023718745,
0.010745725,
-0.0032253456,
-0.010667574,
-0.026701499,
0.016073,
0.0008393062,
-0.024526304,
-0.011781222,
-0.014171331,
-0.011507695,
-0.022416234,
0.007925786,
0.003995456,
-0.021960353,
-0.022312032,
-0.02464353,
-0.0076066707,
-0.0070856656,
-0.008127675,
-0.031624995,
-0.0017209441,
0.008108138,
0.1931886,
-0.017505763,
0.0050602597,
-0.0031341698,
0.009247836,
-0.005994812,
-0.002298934,
-0.0011624921,
-0.014457884,
0.0064116158,
0.008590068,
0.009293424,
-0.0064441785,
-0.0005726983,
0.0044285413,
-0.02266371,
-0.012784156,
0.0024796573,
-0.00918271,
-0.016945682,
0.028186362,
-0.007587133,
-0.0022354363,
-0.011234167,
0.056737427,
0.0035493455,
-0.019615833,
-0.0067470125,
0.014783512,
-0.0052491236,
-0.037408147,
0.0049397773,
0.006017606,
-0.0075936457,
0.012354327,
0.0062097264,
-0.014028056,
0.0058287415,
0.002720622,
0.008967795,
0.0017714164,
-0.0064995354,
0.009091535,
-0.020280113,
0.0030006622,
0.0072224294,
0.010270308,
-0.008016962,
-0.012751593,
-0.011383955,
-0.04316525,
0.01788349,
0.012686468,
0.0042201392,
-0.0037642599,
-0.012334789,
0.0118268095,
0.009820941,
-0.015226366,
0.02314564,
-0.006636299,
0.0042820084,
-0.03420397,
0.007958349,
-0.00097607,
0.03649639,
0.0065125604,
-0.002775979,
0.017453661,
-0.038137555,
-0.012569242,
0.0077759973,
-0.002508964,
-0.0052686613,
-0.011156016,
-0.008844057,
0.016763331,
0.025412012,
0.025438061,
0.03321406,
0.024122523,
-0.013415875,
-0.0374863,
0.023562444,
-0.01396293,
-0.019720033,
0.0004982109,
0.017453661,
-0.016502827,
-0.008980821,
0.009482288,
-0.028863668,
-0.0084402785,
0.0024536073,
0.018925501,
-0.006681887,
0.020332213,
0.0014579995,
-0.010270308,
-0.01823517,
-0.0030364813,
0.063302085,
0.008003937,
0.0043731844,
-0.014627211,
0.019107852,
0.0013114669,
0.010127031,
-0.0034093254,
-0.016346527,
0.01398898,
-0.03863251,
0.004786732,
-0.002495939,
0.0029436774,
0.022338083,
0.011527232,
-0.007495957,
0.014483934,
0.0053858873,
-0.009469263,
-0.012979533,
-0.0127711315,
0.025268735,
0.010127031,
0.0073136054,
-0.025581338,
-0.009820941,
-0.0068968018,
-0.043556005,
-0.011221142,
-0.008720319,
0.009404138,
0.045353472,
-0.009000358,
-0.017128034,
0.012341302,
-0.01452301,
-0.03665269,
0.015877623,
0.00039767323,
-0.0126408795,
0.0067209625,
-0.010674086,
-0.0153696425,
-0.011891935,
0.0188213,
0.022911187,
-0.01994146,
0.00071516057,
-0.0050830534,
-0.028603166,
-0.0037023907,
-0.014418809,
0.020267088,
-0.022168756,
-0.021647751,
-0.0064116158,
0.009645103,
0.003858692,
-0.01345495,
-0.00052792445,
0.00016362808,
-0.008720319,
-0.011390468,
-0.015460819,
-0.16328292,
-0.0005193767,
-0.0031162603,
-0.011996136,
0.014236458,
0.02085322,
0.0033865315,
0.003728441,
-0.010335433,
0.020814143,
0.04522322,
0.0038847423,
-0.03550648,
-0.0031651044,
-0.007749947,
-0.0059752744,
-0.02098347,
0.040429976,
0.004702069,
0.019081803,
0.031677093,
-0.009593002,
0.023327991,
0.011846348,
0.0058157165,
0.02650612,
0.024200674,
-0.003731697,
-0.002893205,
-0.028316613,
-0.0035428328,
0.010973664,
0.032771204,
0.000091888156,
0.029671226,
0.0063855657,
0.0030364813,
-0.01266693,
0.0037447223,
0.009612539,
0.035115726,
0.018717099,
-0.00059671333,
0.00058735156,
-0.007860661,
0.026636373,
0.0015214969,
0.0056496463,
0.015356618,
-0.03886696,
0.020254062,
-0.022859087,
0.010120519,
0.023132615,
0.040351823,
0.031859446,
0.001789326,
0.0135331005,
-0.0039531244,
0.0059687616,
-0.018456597,
0.003995456,
0.021908253,
-0.0034484009,
0.008056037,
-0.034177918,
-0.008205826,
-0.006310671,
-0.023666644,
0.002196361,
-0.01927718,
-0.01350705,
0.015226366,
-0.022064555,
0.027587207,
0.021895228,
-0.007815072,
0.010771775,
0.023262866,
-0.015734347,
-0.005109104,
0.009938167,
-0.03191155,
-0.010328921,
-0.020722967,
0.012041724,
0.021022545,
0.029983828,
0.0050146715,
-0.019472556,
0.0111690415,
-0.021830102,
0.0006659093,
-0.016854506,
0.007495957,
0.030973738,
-0.020019611,
-0.0214654,
-0.0053761187,
0.0044708727,
0.04514507,
-0.03446447,
-0.0012471554,
-0.009404138,
0.021113722,
-0.010635011,
-0.038215704,
0.017675089,
0.03344851,
-0.010296358,
-0.022064555,
-0.0050635156,
0.0024731448,
0.019446505,
0.008577042,
0.014926788,
-0.004073607,
-0.018026767,
0.008752882,
-0.026362846,
0.061061766,
-0.0027450442,
0.0027596976,
0.024708655,
0.006287877,
-0.028577115,
-0.122019336,
-0.024044374,
0.023028415,
-0.0023494062,
-0.034829173,
0.02108767,
-0.0053598373,
0.025242684,
0.0001352374,
0.014991914,
-0.035819083,
-0.013910829,
-0.001289487,
-0.01317491,
0.003995456,
0.008642168,
0.023770846,
-0.006532098,
-0.037095543,
0.04188879,
0.0021084414,
-0.0137936035,
0.00918271,
-0.0017486225,
-0.0043113152,
-0.016971733,
-0.038163606,
0.0126408795,
0.0063139275,
0.017349461,
-0.00075464294,
-0.0012691353,
0.020540616,
0.00457833,
-0.013116296,
0.0062813647,
-0.0073070927,
0.012158951,
0.043738358,
-0.015174266,
0.0010241001,
0.011182066,
-0.002999034,
-0.008837544,
-0.019602807,
-0.015460819,
-0.016515853,
0.0038163604,
0.023640595,
-0.012100337,
-0.03542833,
-0.03113004,
-0.022950264,
-0.006981465,
0.0111169405,
-0.02589394,
0.0005006531,
0.024057398,
-0.015630145,
-0.009742791,
0.013871754,
-0.0077759973,
0.015096115,
-0.0003313265,
0.041237533,
0.0010908538,
0.005183998,
-0.031364493,
0.04649968,
-0.011650971,
-0.021165822,
0.0135331005,
-0.008472841,
-0.0093064485,
-0.013741503,
-0.0009003615,
-0.018300295,
-0.0023103307,
0.01513519,
-0.017206185,
-0.01945953,
-0.008277465,
0.023354042,
-0.016411653,
0.030609034,
0.018664999,
0.022924213,
-0.014288558,
0.014197382,
-0.012217564,
-0.024539327,
0.04636943,
0.000685447,
-0.0036795966,
0.00010949242,
0.0068381885,
-0.0018381702,
-0.005343556,
0.017922567,
0.01314886,
-0.03540228,
-0.018157018,
-0.057414733,
0.024930082,
-0.012119875,
0.005845023,
0.010602448,
-0.024083449,
0.01788349,
-0.020996494,
0.008668218,
-0.010420097,
-0.0038847423,
-0.000042051808,
-0.029254422,
0.0033539687,
-0.0065614046,
-0.002811798,
0.027483005,
-0.01828727,
0.023992272,
0.030114079,
0.0017453663,
-0.0075154947,
0.017466687,
0.001220291,
-0.0026522402,
-0.0110648405,
-0.02037129,
0.01561712,
-0.002660381,
0.0046564806,
-0.005030953,
-0.06043656,
-0.010973664,
0.0075220075,
-0.014692336,
-0.030582985,
0.0030429938,
0.022207832,
0.030114079,
0.01284277,
-0.02650612,
-0.03899721,
0.014002005,
-0.007945323,
0.0062227515,
-0.012504116,
-0.03527203,
-0.006030631,
0.018560797,
0.014392759,
0.037877053,
0.0002521582,
0.014861663,
-0.02627167,
-0.019016678,
-0.0085444795,
0.0039205616,
-0.005929686,
-0.011149503,
-0.01988936,
0.009599514,
0.0152393915,
0.009729765,
-0.0018137482,
0.009912117,
-0.024252776,
-0.02199943,
0.0010794569,
0.007352681,
-0.02439605,
-0.024851931,
0.0068121385,
0.010087956,
0.0152654415,
0.014197382,
0.0017111753,
-0.024148574,
0.008231876,
-0.03201575,
-0.008668218,
0.0068251635,
0.0047606817,
-0.01447091,
0.0045750737,
0.037877053,
-0.005206792,
-0.0111690415,
0.022429258,
-0.009189223,
0.002147517,
-0.011162529,
0.015174266,
-0.0011600498,
0.01813097,
-0.005626852,
0.017727189,
0.004535998,
-0.0019456275,
0.006903314,
0.05845674,
0.00036755262,
0.0069423895,
-0.009143635,
-0.027040152,
-0.010602448,
0.043738358,
-0.041654337,
-0.04642153,
-0.016919632,
-0.012491091,
0.0032253456,
0.0073722186,
-0.0051318975,
-0.0059687616,
-0.013129322,
-0.012484578,
-0.0026636373,
-0.0050244406,
-0.012452016,
0.030452732,
0.0018023511,
0.010804337,
-0.0016305824,
-0.009990267,
0.008687756,
-0.007736922,
0.025594363,
-0.0137936035,
0.011305805,
-0.028733417,
0.007945323,
-0.0028378482,
-0.023718745,
-0.0077238968,
-0.0059329425,
0.0038945111,
0.014275532,
0.026962,
-0.026024193,
0.09206156,
-0.0006899244,
-0.02042339,
-0.014223432,
-0.0046434556,
0.0432434,
-0.002056341,
-0.0024536073,
-0.024044374,
-0.030973738,
0.0028866925,
-0.031651042,
0.031755246,
-0.04181064,
-0.020514566,
0.012230589,
-0.0135331005,
-0.007678309,
0.00309021,
-0.01449696,
-0.003555858,
-0.009345524,
-0.0064767413,
0.02520361,
-0.03118214,
0.0011356277,
0.037981253,
0.014002005,
-0.0021898486,
-0.03339641,
0.0023835972,
-0.019876335,
-0.041211482,
0.0051807417,
0.0017811853,
-0.027717458,
-0.012601805,
-0.043035,
0.013741503,
0.018704074,
-0.00042494456,
0.01050476,
-0.02683175,
-0.021113722,
0.02199943,
-0.00024584917,
-0.008818007,
-0.0014856779,
0.0024112756
] |
All organisms must trade off resource allocation between different life processes that determine their survival and reproduction. Malaria parasites replicate asexually in the host but must produce sexual stages to transmit between hosts. Because different specialized stages are required for these functions, the division of resources between these life-history components is a key problem for natural selection to solve. Despite the medical and economic importance of these parasites, their reproductive strategies remain poorly understood and often seem counterintuitive. Here, we tested recent theory predicting that in-host competition shapes how parasites trade off investment in in-host replication relative to between-host transmission. We demonstrate, across several genotypes, that Plas | [
-0.00031508846,
-0.016089337,
0.019058846,
-0.013450524,
0.0005804039,
0.030666923,
-0.0077274707,
0.0049975477,
-0.01498252,
-0.037199844,
0.014280636,
0.012532676,
0.008631821,
-0.015050009,
0.0003254227,
0.0013143449,
0.035067197,
-0.019274808,
-0.0055610794,
-0.0046601035,
-0.010427024,
0.007194309,
-0.0011658695,
-0.012350456,
-0.0016492582,
0.01698019,
0.009097494,
-0.024903378,
0.008483346,
-0.0026860554,
0.005024543,
-0.016062342,
-0.021704407,
-0.027251989,
-0.031935714,
-0.030127013,
0.014753058,
-0.011729558,
0.0064249365,
0.0070323357,
-0.025186831,
0.012546173,
-0.0030977372,
0.0019352421,
0.005328243,
0.029803067,
-0.019463778,
0.009367449,
-0.027670419,
0.007018838,
0.016156826,
0.00046103305,
-0.024053019,
0.011851038,
-0.007835453,
-0.017533598,
0.005341741,
0.0035499125,
0.025726741,
-0.03352845,
-0.014226645,
-0.0076734796,
-0.03714585,
-0.00067952817,
-0.010298795,
0.025348803,
0.013916196,
-0.0056083216,
0.030882888,
0.009745386,
0.04586541,
0.011344872,
-0.0036207756,
0.006839993,
-0.0013801465,
-0.039170515,
-0.03474325,
0.008726305,
-0.00030601965,
0.016102834,
0.02030064,
-0.0010384844,
-0.021150999,
0.015454941,
0.005399106,
-0.014348125,
0.01600835,
0.026307145,
0.008672315,
0.016777722,
0.0016661305,
0.011979267,
0.015873373,
0.023634588,
-0.018100504,
0.008537337,
-0.010838706,
0.034878228,
0.005999757,
-0.015400951,
0.00025455942,
0.021299474,
-0.013369537,
-0.0077612153,
-0.010352787,
0.025524275,
0.0020837176,
-0.0057365503,
0.011466352,
-0.024727907,
-0.024795396,
0.033933382,
-0.0065767863,
-0.05412604,
0.011392114,
-0.009461934,
0.011452855,
-0.01486104,
-0.031179838,
-0.0036983879,
0.014712565,
-0.028129343,
0.00033217156,
0.006971596,
0.032880556,
0.0010764468,
-0.016440278,
0.006843367,
-0.011729558,
-0.005429476,
-0.005861405,
0.027548939,
0.001872815,
0.027548939,
-0.028480286,
-0.0060976157,
-0.022419788,
-0.020165661,
-0.012073752,
-0.0009971474,
0.007943435,
0.016345793,
-0.025092347,
-0.011365118,
-0.0017294012,
0.030936878,
0.032043695,
0.009549669,
-0.0042248005,
0.025807727,
0.015265973,
-0.001024143,
0.025213826,
-0.009434938,
0.006964847,
0.029398134,
-0.014712565,
0.012026509,
-0.004525126,
-0.007133569,
0.01129763,
0.018464943,
-0.0073900265,
0.019463778,
0.00003424531,
0.028183335,
0.005483467,
0.02996504,
0.027967371,
-0.013740726,
-0.006046999,
0.015211982,
-0.028669255,
0.03660594,
-0.0015665845,
0.019976692,
-0.027157504,
0.014901534,
-0.014415613,
0.0074575157,
0.01062949,
0.011392114,
0.012343707,
0.0070930757,
-0.01262716,
0.020408621,
0.011432608,
-0.0099681,
0.012161487,
0.009347202,
0.0017310885,
0.0062730866,
0.001842445,
0.008220139,
-0.6383903,
0.0064823017,
0.013065837,
-0.026509611,
0.005453097,
-0.0024161001,
0.026388131,
-0.0009102556,
-0.016953195,
0.026307145,
-0.0033997498,
0.00074068987,
0.004633108,
-0.03606603,
-0.002392479,
-0.04162711,
0.006931103,
-0.022500776,
0.00501442,
0.006735385,
0.0014586023,
-0.0049266843,
0.010575499,
0.027009029,
-0.013477519,
0.0049570543,
0.054207027,
-0.0086048255,
-0.0059221447,
0.026833558,
-0.0044306414,
0.032205667,
-0.032529615,
0.00718756,
0.046675272,
-0.006910856,
0.009981598,
0.027144007,
0.02289221,
0.027036024,
-0.02012517,
-0.012633909,
0.016521266,
-0.010278548,
0.010514759,
-0.0025493905,
0.0020735941,
0.0052607544,
-0.010406777,
-0.0022709991,
0.0070660803,
0.0035026702,
-0.0124044465,
0.024228489,
0.0205436,
0.011068168,
0.0042754174,
-0.038630605,
0.0058141625,
0.011965769,
-0.015265973,
-0.013396532,
0.006475553,
-0.018613419,
-0.029884053,
0.0022693118,
-0.01353151,
0.0052405074,
-0.005716304,
-0.018437948,
0.014901534,
0.020219654,
-0.029344143,
-0.008712808,
0.0047208434,
0.025092347,
0.0026303772,
-0.006428311,
-0.02821033,
0.013086083,
-0.0022743735,
-0.0019099339,
-0.012370702,
-0.009043503,
0.023189161,
-0.029128179,
0.004066202,
0.0069918428,
0.009036754,
0.020165661,
0.038441636,
0.026199164,
-0.00066223415,
-0.011986016,
-0.014645075,
0.015684403,
-0.02591571,
-0.021920372,
0.0023857302,
-0.027130509,
0.009097494,
-0.0107037285,
0.0076937266,
-0.0055239606,
-0.00089169614,
0.0289932,
-0.026307145,
0.006536293,
0.033366475,
-0.032853562,
-0.009306709,
-0.014901534,
-0.009988346,
-0.0124044465,
0.017898038,
-0.020152165,
0.025240822,
0.007653233,
0.019922702,
-0.02440396,
0.037928723,
0.008773548,
0.0121142445,
-0.026185665,
0.005537458,
0.022527771,
-0.007997426,
-0.019895706,
-0.004204554,
0.00013065415,
0.0042990386,
-0.016399786,
0.02864226,
-0.0043665273,
0.033015534,
-0.0036039033,
0.0235536,
0.008361866,
0.024795396,
-0.03366343,
-0.005719678,
-0.030100018,
0.0010907882,
-0.00033575692,
-0.010055835,
-0.016939696,
0.002249065,
-0.0026101305,
-0.00042876496,
-0.007302291,
0.004059453,
0.0032225915,
-0.0066881427,
0.013943192,
0.0022389418,
-0.009347202,
0.0013135013,
-0.031206835,
-0.042194016,
-0.0021849507,
0.015873373,
-0.011905029,
-0.019126333,
0.017776558,
-0.005993008,
-0.009488929,
0.0067725037,
-0.0017344629,
0.0071470668,
-0.02379656,
0.02332414,
-0.010953437,
-0.03333948,
0.007099825,
-0.008064915,
0.0007567185,
0.02089454,
0.002232193,
-0.016237812,
0.002394166,
-0.008348368,
-0.008658817,
-0.01799252,
-0.009144736,
0.018964361,
0.014591085,
0.038738586,
0.02428248,
0.028615262,
0.042571954,
0.031503785,
0.03463527,
-0.02301369,
0.00045850224,
0.00247684,
-0.010575499,
-0.010055835,
0.047917068,
0.0008950706,
0.027670419,
0.01171606,
-0.018073509,
-0.028237326,
-0.026050687,
0.027090015,
-0.017803553,
-0.00014931904,
-0.017088171,
0.032178674,
0.024376964,
0.020408621,
-0.025470283,
0.004572368,
-0.013295299,
0.022284811,
0.014780053,
0.0023992278,
0.018221984,
-0.0035330402,
0.021474944,
-0.015576421,
-0.0013700232,
0.02676607,
-0.010771217,
-0.008571081,
0.004440765,
0.003057244,
0.0156034175,
-0.007936686,
-0.008908525,
-0.009475431,
-0.0036106524,
-0.0016610688,
-0.0012063629,
0.04524451,
0.013794716,
0.001288193,
0.0050346665,
0.035364147,
-0.0077274707,
0.004815328,
-0.010069333,
0.0054395995,
0.0148745375,
0.01637279,
-0.0020398498,
0.026253155,
0.013315545,
-0.024943871,
0.011486598,
-0.019072343,
0.014213148,
-0.013194066,
-0.013315545,
0.0052168863,
-0.013706981,
0.00044078642,
0.0065329187,
0.022581762,
0.015117497,
-0.0019622378,
-0.0145640895,
-0.011371868,
-0.017385121,
-0.0011920214,
-0.011608078,
0.006148232,
-0.045109533,
-0.0016998749,
0.006232593,
-0.015954359,
-0.0027197998,
0.0076464843,
-0.016899202,
-0.016467273,
0.012863371,
-0.007848951,
-0.017857544,
-0.01154059,
-0.014550592,
-0.032043695,
-0.018383957,
0.023513108,
0.03279957,
-0.0024059766,
-0.05733851,
-0.011689065,
0.022298308,
-0.011088414,
-0.0005778731,
-0.0042551705,
-0.0057365503,
-0.0069513493,
0.0006845898,
-0.009360701,
-0.00743052,
0.029263156,
-0.010076082,
0.007707224,
-0.0047208434,
0.00030791777,
0.010312293,
-0.028102348,
-0.008206641,
0.013383035,
0.015913866,
-0.015279471,
-0.02144795,
-0.011007428,
-0.022095842,
0.009569916,
-0.042814914,
-0.013281802,
-0.0038434889,
-0.0014122038,
-0.0035971545,
-0.030477954,
0.021218488,
0.0129646035,
0.0019504272,
-0.024822392,
-0.011392114,
-0.009779131,
-0.022865215,
0.060415998,
0.023040686,
-0.016642746,
0.034770243,
0.00972514,
0.00863857,
0.018397454,
0.0021377087,
0.034095354,
-0.014915031,
-0.00507516,
-0.005571203,
0.02549728,
0.010825208,
0.017560594,
0.010906194,
-0.022257816,
-0.00894227,
-0.019153329,
0.037226837,
0.018613419,
-0.028966205,
0.010723975,
0.036497958,
0.018586423,
0.018073509,
-0.016629247,
-0.0041336906,
-0.0005761859,
-0.00250721,
-0.014415613,
-0.012046756,
0.0024582807,
0.032880556,
-0.0010190813,
0.0006917605,
0.007045834,
-0.0004804361,
0.0031736621,
0.012573169,
0.031206835,
0.022514272,
0.005442974,
0.0026118176,
0.00064662733,
-0.012242474,
-0.022095842,
0.0093741985,
-0.00900301,
-0.01274864,
0.028669255,
0.0006462055,
-0.029803067,
-0.0055914493,
0.038252667,
0.006985094,
0.006900733,
0.010116575,
-0.012802631,
-0.010777966,
-0.019666245,
-0.030046027,
0.036821906,
-0.006812997,
0.008091911,
0.017290637,
-0.0126946485,
-0.0065126717,
-0.03414935,
-0.026023692,
-0.0006605469,
-0.051615454,
-0.007106574,
-0.004180933,
-0.007221305,
0.016318798,
0.009090745,
-0.028129343,
-0.0022186951,
0.0102245575,
-0.013180568,
-0.021569429,
-0.008773548,
-0.043354824,
-0.0055914493,
-0.007659982,
0.009529423,
0.0003730867,
-0.021785393,
-0.0029239536,
-0.001283975,
-0.0008647006,
0.0018019517,
-0.014105165,
-0.02320266,
0.012998348,
0.014685569,
0.03328549,
-0.004089823,
0.0014408865,
-0.010400028,
-0.018788889,
-0.014712565,
-0.032043695,
-0.0062798355,
-0.0025291438,
-0.011986016,
0.007950184,
-0.036039036,
-0.032475624,
0.018896872,
-0.013902699,
0.019423285,
0.009677898,
0.032313652,
0.023283646,
0.0086048255,
0.015616915,
0.00637432,
0.0025746988,
0.0027046148,
-0.002959385,
0.015238977,
0.025281316,
-0.02024665,
0.011365118,
0.010609244,
-0.037469797,
-0.014010681,
-0.0037017623,
0.019193823,
0.04662128,
0.007376529,
-0.030693918,
-0.0074102734,
-0.0016619124,
-0.00718756,
0.008388861,
-0.004403646,
0.0019672993,
0.014186151,
0.005841158,
-0.0068602394,
-0.015090502,
0.029398134,
-0.037469797,
-0.009475431,
0.011581083,
-0.009252719,
0.016480772,
-0.012633909,
-0.022055348,
-0.011986016,
0.014091668,
-0.009407943,
-0.031665757,
-0.003150041,
-0.02374257,
0.032610603,
0.02343212,
0.015468439,
-0.017857544,
0.01226272,
0.001941991,
0.012559671,
-0.01781705,
0.007882695,
0.0021124003,
-0.008557583,
0.01612983,
0.026010195,
0.016237812,
-0.012458438,
0.010919692,
0.019490773,
0.046378322,
-0.029020196,
-0.021623421,
-0.022919206,
-0.016210817,
0.0047984556,
0.0016787846,
-0.006492425,
0.005021169,
-0.04119518,
0.00643506,
0.014402116,
0.006381069,
0.018046513,
-0.0066071562,
0.010582249,
-0.009036754,
0.016480772,
0.0032664593,
0.018451445,
-0.02011167,
-0.0009718391,
-0.004903063,
-0.012512429,
-0.009178481,
0.013032093,
-0.0006196318,
0.0151039995,
-0.004531875,
0.010258302,
0.022325305,
-0.019477276,
-0.015090502,
0.0026607472,
-0.008085161,
-0.021596424,
0.008321373,
-0.020759564,
-0.033987373,
-0.012303214,
0.011709312,
-0.0049806754,
0.010413527,
-0.007423771,
-0.01117615,
0.026361136,
-0.005712929,
0.016683238,
-0.012033258,
0.033447463,
0.017844046,
-0.017736064,
-0.01685871,
-0.018343464,
0.0032664593,
0.0078084576,
0.027778402,
0.009050252,
-0.018100504,
-0.025578266,
0.017182656,
0.014631578,
0.0049266843,
-0.02144795,
0.0020668453,
-0.0021765146,
0.008186395,
-0.00013624308,
-0.0050346665,
-0.02024665,
0.014037676,
-0.024565933,
-0.011756554,
0.01026505,
-0.016318798,
-0.011574334,
0.005345115,
0.019180326,
0.02379656,
0.004029083,
-0.008766799,
-0.004373276,
-0.02464692,
-0.01178355,
0.0017715817,
0.010852204,
0.009509176,
-0.007862449,
0.0002518177,
0.0023351135,
0.011493348,
-0.026172167,
-0.014456107,
-0.018167993,
0.038009707,
0.0039852154,
0.008510341,
-0.006583535,
0.034770243,
-0.0032917676,
0.014213148,
0.0022237569,
0.0022203824,
0.008449601,
-0.0047512134,
0.04022334,
0.029344143,
0.00027332976,
-0.03347446,
-0.01703418,
0.015846377,
-0.018140998,
-0.015954359,
0.011810545,
-0.012573169,
0.005864779,
-0.0066611473,
-0.004700597,
0.03225966,
0.0043395315,
-0.008422606,
-0.018707903,
0.029155174,
-0.013180568,
0.02024665,
0.014766555,
0.0023570473,
-0.01444261,
0.015913866,
-0.0015429633,
-0.017182656,
0.01069023,
-0.012431442,
-0.023418624,
0.004342906,
-0.022203825,
0.01612983,
-0.018532433,
-0.006759006,
0.007666731,
0.00022714208,
0.016035346,
-0.020084675,
-0.0025139588,
0.027332975,
0.01612983,
-0.01328855,
0.032529615,
-0.012606913,
0.0016163575,
-0.018910369,
0.006931103,
0.009549669,
-0.024093512,
-0.016089337,
-0.021677412,
0.010069333,
0.0030100017,
-0.014145658,
0.0050920323,
-0.027413962,
-0.017614584,
-0.006296708,
-0.0014543843,
-0.018694405,
-0.009887113,
-0.01733113,
0.014226645,
-0.0045926147,
-0.010217808,
0.01322781,
0.003485798,
-0.03509419,
-0.040142354,
-0.01461808,
-0.015562924,
0.040088363,
-0.008753301,
-0.008442853,
-0.009320207,
-0.0024549062,
-0.03962944,
-0.0068939836,
0.0048119533,
-0.006175228,
0.020435616,
0.0223523,
0.011459603,
0.024012525,
0.025848221,
0.0072415513,
0.006232593,
-0.009657651,
0.02301369,
0.0018863127,
0.01625131,
-0.0036207756,
-0.032934546,
-0.016021848,
0.028507281,
-0.029641094,
0.014955524,
0.020557096,
-0.014888035,
-0.0020938409,
-0.00978588,
0.029506115,
0.0037321323,
0.014901534,
0.013281802,
-0.03593105,
-0.03544513,
0.01673723,
0.005962638,
-0.016723732,
-0.0037422555,
-0.01359225,
-0.008071664,
0.016629247,
-0.031260826,
-0.027602931,
0.019625751,
-0.017479606,
0.03396038,
0.0024346595,
0.02953311,
0.018383957,
0.012539424,
-0.007423771,
-0.0011743056,
0.010588997,
-0.01757409,
-0.0018103878,
0.007929937,
0.01111541,
-0.0051156534,
0.0039615943,
0.0016703485,
-0.0132143125,
0.010541755,
-0.002591571,
-0.031206835,
-0.033015534,
0.020462614,
0.000898445,
-0.006701641,
0.01437512,
-0.0032310276,
-0.0091244895,
-0.01178355,
-0.008220139,
0.0031635389,
0.01195902,
0.027251989,
-0.007605991,
-0.021758398,
0.006239342,
-0.007592493,
-0.0054159784,
-0.031935714,
0.009549669,
0.1781705,
-0.0048659444,
0.009428189,
0.025024857,
-0.00092459697,
-0.018788889,
0.020341134,
-0.008253884,
-0.0017648329,
0.022041852,
0.0025561394,
-0.011749805,
0.0061111134,
0.0036443968,
-0.0014661947,
-0.017007185,
-0.032232665,
0.007484511,
-0.013585501,
0.010069333,
0.0032394638,
-0.012640658,
-0.005453097,
-0.015481937,
0.031044861,
0.0056083216,
-0.030423963,
-0.014928529,
-0.005972761,
0.0011034424,
-0.010858952,
-0.0017462735,
-0.0070930757,
0.007983929,
0.008294377,
-0.004228175,
-0.0005960107,
-0.011945522,
0.016872207,
-0.013383035,
0.008989512,
0.032826565,
0.018572925,
-0.0075722467,
0.0030100017,
0.031125847,
-0.010663235,
-0.011763303,
-0.0032613976,
0.0038873565,
-0.055394832,
-0.008125655,
-0.014037676,
0.022784228,
-0.0101840645,
0.018977858,
0.017830549,
-0.01673723,
-0.010190813,
0.028237326,
-0.011999514,
0.00882079,
-0.024147503,
0.00029210007,
0.009036754,
0.04537949,
-0.03836065,
0.025537772,
-0.005709555,
-0.0022372548,
-0.0077612153,
-0.019315302,
-0.010831957,
-0.004849072,
0.0063102054,
-0.012910613,
0.033177506,
0.013578752,
0.030747911,
0.0019656122,
-0.01793853,
0.006087492,
-0.021569429,
0.018842882,
0.0026405004,
-0.03944047,
0.04100621,
0.009387696,
-0.03498621,
-0.007842202,
0.008341619,
-0.020503106,
-0.02942513,
-0.013956689,
0.011412361,
0.0010300482,
0.020192657,
-0.0020044183,
-0.0013961751,
-0.037037868,
-0.015144493,
0.0706743,
0.018019518,
0.0082741305,
0.006289959,
0.0072483,
0.0011827417,
0.023162166,
0.032367643,
-0.028048357,
0.017290637,
-0.013356039,
0.006023378,
-0.0017682073,
0.021542434,
0.011567585,
0.017682074,
-0.019274808,
0.022703242,
0.013126577,
-0.022433287,
-0.031881724,
0.0072820447,
0.006664522,
-0.012937608,
-0.03147679,
-0.017979024,
0.0148340445,
-0.012579918,
-0.0052270098,
-0.002728236,
-0.01722315,
-0.028534276,
0.010022091,
-0.0073225377,
-0.0051797675,
0.013160322,
-0.010663235,
-0.01274864,
0.021690909,
-0.010143571,
0.0019689866,
-0.0028007864,
0.01727714,
0.00070230564,
-0.033636432,
0.0040392065,
0.013200815,
-0.01328855,
-0.0052911243,
-0.0096644005,
-0.014078169,
-0.0088545345,
-0.008031171,
0.0005344272,
-0.001682159,
-0.014010681,
-0.036524955,
0.04494756,
-0.015238977,
-0.022122838,
0.009995095,
0.00869931,
-0.008422606,
0.013497766,
-0.0153739555,
-0.17115167,
0.008240386,
0.003249587,
-0.005665687,
0.018100504,
0.0057534226,
0.007923189,
0.0036612689,
-0.017965525,
0.006637526,
0.011689065,
0.021420954,
-0.014523596,
-0.01734463,
0.0023840428,
0.0016914387,
-0.012620411,
0.02918217,
0.010872451,
0.005800665,
0.03420334,
-0.010987181,
-0.0018610044,
-0.00839561,
0.008706058,
0.018950863,
-0.0011456228,
0.008969265,
-0.0073562823,
-0.037793744,
-0.015805883,
0.01183754,
0.01437512,
0.011587832,
-0.003301891,
-0.0026624342,
-0.0140646715,
-0.012168236,
-0.011486598,
0.010656486,
-0.00032099374,
-0.018815886,
0.006151607,
-0.010865701,
0.0023806684,
0.028183335,
-0.021839384,
0.0040459554,
0.01008958,
-0.0049098125,
0.015441444,
0.016710233,
-0.021474944,
-0.00613136,
0.0137339765,
-0.011641823,
0.0024937121,
0.008625072,
0.014213148,
-0.0077544665,
-0.00048549776,
-0.01432113,
0.029830063,
-0.014969022,
0.00033638964,
-0.015023014,
-0.01746611,
0.026469119,
-0.021785393,
0.008071664,
-0.01135837,
0.017682074,
0.015900368,
0.000055520108,
0.015994852,
0.018950863,
-0.019031849,
0.024053019,
-0.014226645,
-0.009927606,
-0.012397698,
0.021070013,
0.0012350456,
-0.012006262,
0.009549669,
-0.014807049,
0.0025477032,
0.0027569185,
-0.002782227,
-0.0008469848,
0.016102834,
-0.024376964,
-0.021663914,
-0.030100018,
0.0050279177,
0.024781898,
0.00027227524,
-0.023945035,
0.014226645,
0.018248979,
0.008307875,
-0.013956689,
-0.029155174,
0.01311308,
0.032880556,
-0.020989025,
-0.0022153207,
-0.022244317,
0.051858414,
-0.000978588,
-0.005628568,
-0.003668018,
0.002232193,
0.028966205,
-0.0034992958,
0.04124917,
0.03593105,
-0.0265771,
0.007336036,
-0.01419965,
0.06198174,
-0.007194309,
-0.022500776,
0.009954602,
0.004717469,
-0.00010434406,
-0.12374751,
-0.0043833996,
-0.01280938,
0.0205436,
-0.0009237533,
0.03514818,
0.003057244,
0.017722566,
0.0008537337,
0.009860118,
-0.030100018,
-0.0075250044,
-0.03709186,
-0.0026050687,
0.008888279,
-0.006519421,
-0.008112157,
-0.0054395995,
-0.001647571,
0.030774906,
0.014915031,
-0.01419965,
-0.0030454334,
-0.019612253,
0.0051156534,
0.026010195,
-0.0033153887,
0.0055543305,
0.0077274707,
0.008429355,
0.0072685466,
0.00008067024,
0.009488929,
-0.028318312,
0.007315789,
0.0016079213,
-0.027238492,
-0.025848221,
0.027508447,
-0.02652311,
-0.0068872347,
0.016426781,
0.026658088,
-0.0045082537,
0.038522623,
-0.010136822,
-0.007774713,
0.018572925,
0.0026337516,
-0.018613419,
-0.04573043,
-0.0074642645,
-0.048915904,
-0.030693918,
0.01250568,
-0.017803553,
-0.01745261,
0.0344463,
-0.000601916,
-0.025173333,
-0.012890366,
0.010588997,
-0.01444261,
-0.0067758784,
0.004676976,
-0.032664593,
-0.025699746,
-0.0046668523,
0.018559428,
-0.04573043,
-0.020084675,
0.012235724,
-0.011324625,
-0.00060908665,
-0.018087005,
0.02138046,
-0.014483103,
-0.014267138,
0.0020128542,
-0.023688579,
0.005793916,
-0.015090502,
-0.0045217513,
-0.03617401,
0.031665757,
0.006033501,
0.004791707,
0.019207321,
0.003072429,
-0.007079578,
-0.041357152,
0.019463778,
-0.0017462735,
-0.039305493,
-0.0046803504,
0.014145658,
-0.012397698,
-0.020408621,
0.008503593,
0.001326999,
-0.035067197,
-0.011041172,
-0.042275,
0.007977179,
-0.01056875,
-0.0062562143,
-0.005787167,
0.02622616,
0.016953195,
0.008868032,
0.0074440176,
0.004663478,
-0.02332414,
0.0052405074,
-0.018842882,
-0.00374563,
-0.0040628277,
0.002957698,
-0.0039548455,
0.011270634,
0.000039623323,
0.016035346,
-0.021798892,
0.012539424,
0.0283993,
0.020449115,
0.01262716,
-0.005544207,
0.0055779517,
0.0032613976,
-0.025942706,
0.0076937266,
0.0073292865,
-0.021717904,
-0.015427946,
-0.003553287,
-0.0032242788,
-0.005081909,
-0.005274252,
0.016291803,
0.020692075,
0.056312677,
-0.028588267,
-0.019976692,
0.0041539376,
-0.042140026,
-0.01371373,
0.007477762,
-0.015994852,
0.0071538156,
0.003981841,
0.0009718391,
0.049644783,
0.0072145555,
-0.0052067633,
-0.013335792,
-0.020395124,
-0.0013598999,
0.0061718533,
-0.012579918,
0.0041876817,
-0.034230333,
0.024970867,
0.018437948,
-0.0076802284,
-0.019261312,
-0.02977607,
-0.035499122,
-0.0024970865,
0.003522917,
-0.005854656,
-0.019423285,
-0.017074674,
0.010285297,
-0.00044458266,
0.009171732,
0.0015505558,
0.025267817,
-0.0008195675,
0.008490095,
-0.009981598,
0.009293212,
-0.0020685326,
-0.00011905451,
-0.036093026,
0.032448627,
0.021339968,
-0.011905029,
0.00072887936,
0.046189353,
0.001143092,
0.019841716,
-0.0069176047,
0.024781898,
0.01160133,
0.0004943557,
0.0011523718,
0.019477276,
-0.006964847,
0.010521509,
0.0083146235,
0.021272479,
0.016696736,
-0.0015902055,
0.026968535,
-0.052695278,
-0.0034301197,
0.016750727,
-0.011520343,
-0.044002715,
-0.008051417,
0.018572925,
-0.00042939768,
0.010501262,
-0.0061954744,
-0.019031849,
-0.004548747,
0.02555127,
-0.01715566,
0.0024717783,
-0.02367508,
0.015063507,
0.003570159,
0.038630605,
-0.024795396,
-0.022068847,
0.023648085,
0.017911535,
0.015508933,
-0.037442803,
0.016305301,
-0.023175664,
0.0181275,
0.0102245575,
-0.02440396,
-0.01957176,
-0.0061954744,
-0.046000384,
0.032610603,
0.009137987,
-0.027400464,
0.07245601,
-0.004616236,
0.00094821805,
0.012485433,
-0.0038232422,
0.016683238,
0.014699067,
0.0042619193,
-0.016561758,
-0.03328549,
0.006205598,
0.002193387,
0.022122838,
-0.014037676,
-0.0026168793,
0.030207999,
-0.04016935,
0.025659252,
-0.0410872,
-0.005527335,
0.02942513,
-0.0008566863,
0.014348125,
0.013929694,
-0.013383035,
-0.0036882644,
0.018815886,
-0.0030234994,
0.0034014368,
-0.0115945805,
-0.0075250044,
-0.022014856,
-0.028426295,
-0.023715574,
0.0013472458,
0.011331374,
-0.008773548,
0.004288915,
0.02972208,
0.023162166,
-0.00652617,
-0.00033491332,
-0.013038842,
-0.030747911,
-0.0061111134,
0.0012207042,
-0.0115945805,
-0.015819382,
-0.019504271
] |
Chronic obstructive pulmonary disease (COPD) is a chronic airway disorder characterized by obstructive airflow limitation which is not completely reversible with treatment. Inflammatory changes in the peripheral airways, especially those with the diameter less than 2mm (so-called small airway disease) have been speculated to be initial steps of COPD. And so it must be quite clear that neutrophils and macrophages play an essential role in the pathogenesis of these lesions. Studies with bronchoalveolar lavage demonstrated an increase in neutrophil numbers and the neutrophil chemoattractant interleukin-8 | [
-0.021084804,
0.008280555,
-0.00292397,
-0.026678206,
-0.026549326,
0.017501935,
-0.017733919,
0.018468536,
-0.0252863,
0.005609512,
-0.008035682,
0.006250691,
0.012817139,
0.031008583,
-0.0065986677,
-0.003924403,
0.038870275,
-0.012623819,
-0.020672388,
-0.009878669,
-0.03923114,
0.032503594,
-0.013152227,
-0.03031263,
0.009988218,
0.0157105,
0.027039072,
-0.03722061,
-0.022399383,
-0.018996945,
0.0048297863,
0.009414701,
-0.006901536,
0.0011977806,
0.0008489985,
-0.0011526726,
0.021471446,
-0.0077521456,
0.0054999636,
-0.0123273935,
0.011637884,
-0.004559138,
0.000028821847,
0.02032441,
0.0021764648,
0.00095371366,
0.026678206,
-0.01629046,
-0.008718748,
-0.0020556396,
0.027606145,
0.0017978791,
0.0025969367,
-0.012759143,
0.004684796,
-0.013519536,
-0.0048458967,
0.020169755,
-0.010490851,
-0.03500387,
-0.014022169,
0.002398783,
-0.024397027,
0.010935487,
-0.01910005,
0.01733439,
-0.008460986,
0.028791843,
0.005119767,
0.021175021,
0.05147476,
0.03273558,
0.0080227945,
0.012166293,
0.007932578,
-0.00065245613,
-0.0049651107,
0.0019670345,
-0.018339656,
0.012604486,
0.025621388,
-0.025698718,
-0.007475053,
0.024860995,
0.018829402,
-0.016535332,
-0.001423321,
0.0032413376,
-0.0060638147,
0.009434032,
0.015349635,
0.0035764263,
0.039256915,
0.013339103,
-0.009511361,
0.026832864,
0.000054371347,
0.029874437,
0.019512467,
-0.023778401,
-0.012314506,
-0.0058608283,
-0.036086462,
-0.007436389,
-0.0271164,
0.0019444805,
-0.005577292,
-0.0025260525,
0.021368342,
-0.0059607103,
0.008918512,
0.037272163,
0.001725384,
-0.037710354,
0.044876095,
-0.006965976,
0.0018381543,
0.012024526,
-0.0070819682,
-0.0130620105,
0.009202048,
0.026652431,
0.012469162,
-0.023430426,
0.0060670367,
-0.014924331,
-0.026600879,
-0.0038438528,
-0.0013186058,
-0.0006339296,
-0.0023794512,
0.026471999,
0.038096994,
0.0031768975,
-0.017811248,
0.0035989804,
-0.025196085,
-0.0013145783,
-0.04033951,
-0.009446921,
-0.002885306,
0.026227126,
-0.007346173,
-0.022592703,
0.015555844,
0.026317341,
0.02886917,
-0.01485989,
0.008009906,
0.0035538722,
0.007243069,
-0.016251797,
0.0003276377,
-0.021729207,
0.010948375,
0.008680083,
0.0004828981,
0.040494166,
-0.011644328,
-0.021394117,
0.008435211,
-0.019383587,
0.023597969,
-0.0046590203,
0.03095703,
0.01257871,
0.013970616,
0.009015172,
0.0015513957,
0.021265237,
-0.000723743,
0.013841736,
-0.012817139,
0.037658803,
0.01688331,
0.008428766,
-0.012797806,
0.009266488,
-0.014821226,
-0.021278126,
-0.015813604,
0.007313953,
0.010471518,
-0.027863905,
-0.024229482,
-0.00062869384,
0.031833418,
-0.0044624778,
-0.008409435,
-0.021020364,
0.0059510446,
0.03193652,
-0.0071335207,
-0.039592005,
-0.63800865,
-0.017824136,
-0.002340787,
0.00095613016,
-0.0020024765,
0.008531871,
0.009021616,
-0.0224896,
-0.007417057,
0.013725744,
0.003937291,
0.010516627,
0.0036827524,
0.015414075,
0.014434585,
-0.017643703,
-0.023533529,
-0.011006371,
0.011921421,
-0.015259419,
0.0024922213,
-0.010490851,
-0.007371949,
0.01733439,
-0.0050811027,
0.024616124,
0.022760248,
-0.0081903385,
0.009530692,
0.03781346,
-0.00038684206,
0.009762677,
-0.000045233937,
-0.0002050001,
0.051655196,
0.0033412199,
-0.0115605565,
0.014821226,
0.01681887,
0.008222559,
0.0019332034,
-0.011914977,
0.01105148,
-0.031266343,
-0.0100591015,
0.021265237,
0.007294621,
0.024319699,
-0.00348621,
-0.015091875,
-0.008119455,
0.0080227945,
0.007384837,
0.011412344,
0.024680564,
-0.012649594,
0.00811301,
-0.030725045,
0.004501142,
-0.005058549,
-0.0029948542,
0.016857533,
-0.01733439,
-0.029101156,
0.0007736841,
0.006862872,
-0.03446257,
-0.0114059,
-0.002819255,
0.014537689,
0.0071013006,
0.027735025,
0.0049167806,
-0.0024503353,
0.017321503,
0.02032441,
-0.014550578,
0.0049457788,
-0.022012742,
0.005677174,
-0.0025324963,
0.013235999,
-0.0155300675,
0.026227126,
0.03407593,
0.017295726,
-0.022579815,
0.0076361536,
-0.01400928,
-0.008982952,
0.004423814,
0.015156315,
-0.01636779,
-0.028688738,
-0.020247083,
0.026910191,
-0.01759215,
-0.005122989,
0.0004845091,
-0.0105939545,
-0.010941931,
0.0025099425,
-0.012456274,
0.013609752,
0.042736683,
0.014640794,
-0.018520089,
-0.009446921,
0.019448027,
-0.02223184,
0.02801856,
-0.003934069,
-0.011798984,
-0.03376662,
0.019989323,
-0.011289908,
0.013190892,
0.0024648344,
0.0004005356,
-0.023430426,
0.011264131,
-0.011992305,
0.0013250498,
-0.016767317,
-0.00006987725,
0.0085898675,
0.0059413784,
-0.02332732,
-0.012179181,
-0.027142176,
0.0026114355,
-0.014834114,
0.012830026,
-0.008100122,
0.02223184,
0.014370145,
0.03513275,
-0.008950732,
-0.0048845606,
-0.04830431,
-0.009086056,
0.0011800596,
0.020917261,
0.006405347,
0.0037181946,
0.0013902955,
-0.013712856,
-0.005348529,
-0.010677727,
0.017257063,
-0.016664213,
-0.008931399,
-0.009040948,
0.041731417,
0.019370697,
0.011476784,
-0.002382673,
-0.014602129,
-0.010484407,
-0.011779653,
0.0025502176,
-0.007417057,
0.0070304163,
-0.0037794127,
-0.010439298,
0.0031495106,
0.007533049,
0.014808338,
0.00020379186,
-0.031240568,
0.006933756,
-0.011380124,
-0.013074899,
-0.0060090404,
0.016135804,
-0.009672461,
-0.016470892,
-0.023481978,
0.0017849911,
-0.008808963,
0.022128735,
-0.015555844,
0.012784919,
0.0013234388,
-0.0020572506,
0.011431676,
0.018661857,
0.00804857,
-0.004633244,
0.05116545,
-0.008473875,
0.018468536,
-0.0054580774,
0.010271754,
0.01000755,
-0.0109226,
0.021922527,
0.008886292,
0.0059800423,
0.030725045,
-0.007520161,
-0.018146336,
0.019796003,
-0.032374714,
0.023739738,
-0.029848661,
-0.0065793353,
-0.0029916323,
0.027271057,
-0.0006693717,
-0.010883935,
0.013803072,
0.014847002,
0.0032461707,
-0.02027286,
0.038741395,
0.013442207,
-0.014769674,
0.0043883715,
-0.018210776,
-0.0107614985,
-0.004733126,
0.026111133,
-0.005190651,
-0.030647717,
0.0051616533,
0.014975882,
0.02025997,
-0.014408809,
-0.012056746,
-0.01134146,
-0.004575248,
0.018172111,
-0.0108581595,
-0.02223184,
0.022515375,
0.0055515156,
-0.0074943854,
0.028534083,
-0.001701219,
-0.00017680756,
0.028121665,
0.01166366,
-0.010278198,
-0.025260525,
-0.019074274,
0.023559306,
0.015916709,
-0.00013381393,
0.006753324,
0.017875688,
-0.0110257035,
-0.0059349346,
-0.0121598495,
-0.022283392,
-0.011238356,
0.021677654,
0.008448099,
0.047994997,
0.01630335,
0.021922527,
-0.032091178,
0.0018510423,
-0.037504144,
0.026575103,
0.014318593,
0.011605664,
-0.03188497,
-0.005316309,
-0.0060799248,
-0.02072394,
0.018056119,
0.018726297,
-0.03500387,
0.026549326,
-0.0054999636,
0.0018188222,
0.001704441,
0.025389405,
0.019125825,
-0.011779653,
-0.01349376,
0.030106422,
0.02886917,
-0.027528817,
-0.004990887,
-0.02515742,
0.0054580774,
-0.0155300675,
0.03222006,
-0.00093679817,
0.015555844,
0.0020169755,
0.020698164,
-0.0124949375,
-0.0037536365,
0.020814156,
-0.0048523406,
0.019138714,
0.017308615,
0.00044463677,
0.0009222991,
-0.01169588,
0.004394816,
0.0059188246,
0.014576353,
-0.009756234,
-0.0044302577,
-0.025015652,
-0.010400634,
-0.0018848733,
-0.025208972,
0.00013532424,
-0.0049071144,
-0.002883695,
0.0038309647,
0.007346173,
0.0017882132,
0.038045444,
-0.018610304,
0.006953088,
-0.036112238,
0.00072575675,
-0.0141639365,
0.025183197,
-0.0013508259,
-0.009620909,
0.02274736,
-0.0070626363,
-0.0032300607,
0.017553486,
-0.014615018,
0.041525207,
0.006337685,
0.007487941,
0.0047202385,
0.040700376,
0.024345474,
0.03433369,
0.017811248,
0.0031575656,
-0.015169202,
-0.011721657,
0.0025163863,
-0.0009778787,
0.012101853,
0.027606145,
0.039128035,
0.0345399,
0.012443386,
-0.0013153838,
0.0037439705,
0.0028981941,
-0.014988771,
-0.03564827,
0.021522997,
-0.005706172,
0.011798984,
-0.013919065,
-0.010742167,
0.011586333,
-0.0071399645,
0.0030206302,
0.016612662,
-0.0006613167,
0.0035603163,
0.0025131644,
0.020556396,
0.022760248,
0.005267979,
0.008074346,
0.024435692,
0.021600327,
-0.012050301,
0.023881506,
-0.013190892,
-0.0059574884,
-0.017476158,
0.020827044,
-0.013777296,
0.016470892,
0.0018011011,
-0.01617447,
-0.02013109,
-0.024989875,
-0.02874029,
-0.00076321256,
-0.0077328137,
-0.020943036,
-0.030286852,
-0.010129985,
-0.0035055422,
-0.021561662,
0.0076039336,
0.0027016518,
-0.03492654,
-0.015426963,
0.008448099,
0.014176825,
0.019112937,
0.036112238,
0.0008022794,
0.0047556804,
0.008912068,
-0.006273245,
-0.005609512,
0.0067791,
-0.024616124,
0.020582173,
-0.010142874,
-0.0047234604,
-0.005915602,
-0.025466733,
0.016264684,
0.021252349,
-0.017733919,
-0.001707663,
0.009330928,
-0.01400928,
0.00337344,
0.018790737,
0.02567294,
-0.0051455433,
-0.03368929,
-0.012011637,
-0.021368342,
-0.02268292,
0.0002517192,
-0.014357258,
-0.03057039,
0.0065471153,
0.0010584289,
-0.0035635382,
0.00080469594,
0.025634278,
-0.025788933,
-0.0024809444,
0.00025030956,
-0.011811873,
0.021742094,
-0.02170343,
0.025724493,
0.024371251,
-0.01479545,
0.012262953,
0.006901536,
0.022541152,
0.012430497,
-0.022798913,
0.008564091,
-0.016844645,
-0.021419894,
-0.040107526,
-0.0048813387,
-0.0037343046,
0.012810694,
0.0009319651,
-0.04974777,
-0.041834522,
0.017218398,
0.0041080574,
0.0015167592,
-0.03474611,
-0.019319145,
-0.009221381,
-0.014035056,
-0.013803072,
0.005035995,
0.06547116,
-0.030235302,
-0.0012146961,
0.014615018,
-0.01993777,
0.0030093533,
-0.026317341,
0.004684796,
0.0027902569,
0.00073421455,
-0.026020918,
-0.013235999,
0.0071915165,
-0.028946498,
0.026111133,
0.021587437,
0.015233642,
-0.013081343,
0.040880807,
0.0064923414,
-0.017849911,
0.0010624564,
-0.008138786,
0.005232537,
-0.015865156,
0.004604246,
0.018455649,
0.0025598835,
-0.0064536775,
-0.030518837,
0.012333837,
0.003985621,
-0.010961263,
-0.001424932,
-0.01349376,
-0.022115847,
-0.029075379,
0.011521893,
-0.014047945,
-0.009034504,
-0.033354204,
-0.0037471927,
0.014305705,
-0.0045784703,
0.0076103774,
-0.018030344,
0.007861693,
-0.0047685686,
0.02215451,
-0.008100122,
0.0025389404,
-0.007997018,
-0.005023107,
0.001163144,
0.006753324,
-0.0019364255,
-0.003937291,
0.0011985861,
-0.02163899,
-0.016251797,
-0.0006504424,
-0.005725504,
-0.011167471,
-0.03273558,
-0.02444858,
-0.040184855,
-0.0060638147,
0.0007998629,
0.0059703765,
-0.048381638,
0.005673952,
-0.0031575656,
0.00142171,
0.01871341,
-0.018365432,
-0.01375152,
0.03363774,
-0.018429872,
-0.0032832238,
-0.052892447,
0.030725045,
0.018545864,
-0.010175094,
-0.038818724,
-0.00026017695,
-0.0104586305,
0.0014821226,
0.031395223,
0.01270759,
-0.028276322,
0.01616158,
-0.015568731,
0.00824189,
0.016316237,
-0.020479068,
0.024319699,
-0.01169588,
0.009504917,
-0.016251797,
-0.010780831,
-0.029230036,
0.001135757,
-0.020736828,
0.0012066411,
-0.023958834,
-0.02287624,
-0.014576353,
-0.010349082,
-0.022399383,
0.014834114,
0.008009906,
-0.006189473,
-0.018275216,
-0.016251797,
-0.01400928,
0.024345474,
-0.008596311,
0.025698718,
0.017605038,
0.0042917114,
0.0061669187,
0.026652431,
0.0025856595,
-0.00088846806,
-0.023237105,
0.039901316,
0.016728653,
-0.0066824397,
0.012340282,
0.0059349346,
0.0075266054,
-0.019009834,
-0.015865156,
-0.037065953,
-0.0072559565,
-0.0025856595,
0.02451302,
0.0113285715,
-0.025660053,
0.00075958786,
-0.013326216,
0.004359374,
-0.016573997,
-0.0063763494,
0.008989396,
-0.021213686,
-0.024719227,
-0.0012066411,
0.0078230295,
0.016844645,
-0.0061314767,
-0.007326841,
-0.014511913,
0.01169588,
-0.026884414,
0.02209007,
0.0015111207,
0.012411166,
0.003985621,
-0.001720551,
-0.029204259,
-0.03082815,
-0.010813051,
0.00058076653,
-0.014176825,
0.0029739111,
-0.013132895,
0.0036473104,
-0.0027983119,
-0.005570848,
0.013274663,
0.007429945,
0.01299757,
-0.015104762,
0.0063602393,
0.038045444,
-0.013113563,
0.0033154439,
0.037839234,
-0.0035667603,
-0.0038180768,
0.029874437,
0.0076941494,
0.029101156,
-0.010909711,
-0.034050155,
-0.023288656,
0.008531871,
-0.022309167,
-0.018945394,
-0.027271057,
-0.0022086848,
-0.0004804816,
-0.0021361897,
-0.0033444418,
0.017566375,
-0.003395994,
-0.010961263,
-0.01590382,
-0.010084878,
-0.02163899,
-0.0061991387,
0.008254779,
0.00032622807,
-0.031266343,
-0.0030737934,
-0.028637186,
0.031163238,
0.002861141,
-0.0041596093,
-0.01039419,
0.012011637,
-0.032168504,
-0.011219024,
-0.011173916,
0.005802832,
0.0020701387,
-0.012817139,
-0.019177377,
0.020762604,
-0.000046744255,
0.008538315,
-0.02515742,
-0.025118755,
0.0049876645,
-0.0076812613,
0.013313327,
-0.0030029092,
-0.008815408,
-0.00038462694,
0.027322607,
0.0041402774,
-0.0083578825,
0.015852267,
-0.0071141883,
-0.02607247,
-0.01169588,
-0.010316862,
0.00079623814,
0.0118956445,
-0.0071399645,
0.010052658,
-0.0066179996,
0.022463823,
0.0053034215,
-0.0011865036,
0.0047556804,
0.021097694,
0.0031446775,
-0.007397725,
-0.0051455433,
-0.031343672,
-0.0018268772,
-0.018146336,
0.012076077,
0.036241118,
-0.025312077,
0.022631368,
-0.0023762293,
-0.01163144,
-0.033328425,
-0.001715718,
0.0083578825,
-0.013764408,
0.006817764,
-0.008544759,
-0.023713961,
0.015027435,
0.009794897,
-0.026961744,
-0.0029465242,
-0.031395223,
0.018648969,
-0.017308615,
0.009730457,
0.0060412604,
0.014138161,
0.009988218,
-0.016045589,
-0.029874437,
-0.012088966,
-0.0012428886,
0.0037536365,
-0.03590603,
0.0097240135,
-0.0043303757,
-0.010735723,
0.0053130873,
-0.0012879968,
-0.02599514,
0.00011951627,
0.028430978,
0.19342345,
-0.019757338,
-0.02013109,
0.009098944,
-0.014847002,
0.006282911,
-0.010587511,
-0.009131164,
-0.0151305385,
0.023481978,
0.047427922,
-0.010149318,
-0.002809589,
0.010207314,
0.012030969,
-0.015916709,
-0.028508306,
-0.0252863,
-0.018558752,
-0.011940753,
-0.010374858,
0.0005497547,
0.027735025,
0.011734544,
0.032091178,
0.0010149318,
-0.0065020076,
0.013738632,
0.02822477,
0.00070239726,
-0.009717569,
0.017733919,
0.003969511,
-0.009685349,
0.0152980825,
0.0048845606,
-0.000015455558,
-0.006315131,
-0.0077199256,
0.0054065255,
0.012076077,
0.0057126163,
-0.00012263759,
0.0025921036,
0.02027286,
0.025956478,
0.005003775,
-0.0060412604,
-0.019924883,
-0.007487941,
-0.024203707,
-0.00684354,
0.008383659,
0.035674047,
0.0018429873,
-0.021999855,
0.0042723794,
0.02861141,
-0.0071141883,
0.0038921828,
-0.021368342,
0.003305778,
-0.020388851,
0.016986413,
-0.0020862487,
0.034436796,
-0.025956478,
-0.0016359733,
-0.029487796,
-0.0059446003,
0.02151011,
-0.020105315,
-0.0037278605,
-0.018597417,
0.0020073096,
-0.013467983,
0.020917261,
0.010407078,
0.010117098,
0.021355454,
-0.015233642,
0.0060799248,
-0.05603712,
-0.014847002,
-0.0110837,
-0.04381928,
-0.0012694702,
0.0030464064,
-0.03905071,
-0.010123542,
-0.007977686,
-0.020350188,
-0.016896198,
0.023469089,
0.052222267,
-0.0017447161,
0.00058882154,
-0.01232095,
-0.008274111,
0.006286133,
-0.014176825,
0.08506095,
0.00042006897,
-0.006096035,
-0.009711125,
0.017179735,
0.0087574115,
0.011682993,
-0.0029481351,
0.001707663,
0.013609752,
-0.025324965,
-0.0061991387,
-0.028302098,
0.010961263,
0.04263358,
0.00824189,
-0.020247083,
0.009337372,
-0.0048104543,
-0.014937218,
-0.012533602,
-0.0010495683,
-0.0010793719,
-0.012475606,
-0.015942484,
-0.023662409,
0.018197889,
-0.010020438,
-0.015517179,
-0.01993777,
-0.012230733,
-0.009608021,
-0.0040758373,
0.007816586,
0.02183231,
0.0038792947,
-0.033869725,
-0.0030302964,
0.0032284497,
-0.015182091,
-0.0012138906,
0.018378321,
0.015762052,
0.028920723,
0.0060412604,
-0.0006258746,
-0.0060412604,
-0.0058253864,
-0.012424054,
-0.022953568,
-0.020285748,
0.015994037,
-0.017540598,
0.006837096,
-0.032503594,
0.0035152081,
-0.0065374495,
-0.0012493327,
0.005696506,
-0.017862799,
0.00016542985,
0.014344369,
0.0044141477,
0.005773834,
-0.02032441,
-0.15960526,
0.013712856,
0.013532423,
0.009466252,
0.0032638917,
0.023108225,
-0.017037965,
0.002228017,
-0.0029223592,
-0.009620909,
0.03446257,
0.011283464,
-0.020221308,
0.005164875,
0.01023309,
-0.00082966645,
0.009981774,
0.02457746,
0.01739883,
0.008531871,
0.038483635,
-0.035570942,
0.004910337,
-0.013210223,
-0.014151049,
-0.0012251677,
0.0050649927,
0.020620836,
-0.016599772,
-0.01617447,
-0.028714515,
-0.0036150904,
0.04613912,
0.014241265,
-0.003347664,
0.013919065,
0.009202048,
-0.028044337,
0.0014700401,
0.0138804,
0.03222006,
0.026575103,
0.007352617,
0.0014861501,
-0.022566928,
0.008937844,
0.01675443,
0.006772656,
0.033611964,
0.016406452,
0.017927239,
-0.01036197,
0.002801534,
0.017901463,
-0.0112448,
0.024139266,
-0.0055354056,
0.027606145,
-0.010484407,
-0.018133448,
-0.013661304,
-0.020633724,
-0.005593402,
0.023752626,
0.011863424,
-0.023933059,
0.00072213204,
0.036266897,
-0.011670104,
0.002788646,
-0.007533049,
-0.013107119,
0.025788933,
-0.007500829,
0.025428068,
0.0021088028,
-0.025208972,
0.025763158,
-0.0018832623,
0.017862799,
-0.0009955998,
0.0065020076,
-0.030261077,
0.0071399645,
0.0035925363,
0.014808338,
0.012630262,
0.008538315,
-0.0025373294,
-0.015955372,
-0.0018607082,
-0.038354754,
-0.00044262302,
0.0053678616,
-0.00095613016,
0.03095703,
0.004961889,
-0.018197889,
-0.023933059,
-0.012855803,
0.01641934,
-0.023933059,
-0.01935781,
0.02451302,
0.037761908,
0.005248647,
-0.011734544,
0.0043335976,
0.04366462,
-0.019796003,
-0.012630262,
0.016702877,
0.020182643,
0.022373607,
-0.016857533,
-0.010349082,
0.026317341,
-0.0020185865,
0.0085254265,
-0.042788234,
0.053820383,
-0.009846449,
-0.004069393,
0.017927239,
0.0064568995,
-0.021033254,
-0.13434474,
-0.0228118,
-0.0066051115,
0.019009834,
-0.042040728,
0.00575128,
-0.013764408,
0.0014523191,
-0.0049071144,
0.009885114,
-0.004478588,
0.007616821,
0.0032703357,
-0.005789944,
0.021935415,
-0.014692346,
-0.0011542835,
-0.008705859,
-0.020298636,
0.006263579,
-0.0069917524,
-0.009620909,
0.023494866,
-0.019963548,
0.005164875,
-0.015800716,
-0.022399383,
0.027657697,
0.0056159557,
0.002268292,
0.015169202,
-0.012063189,
0.0052099833,
-0.00343788,
0.0030077423,
-0.024397027,
0.02221895,
-0.027477264,
0.05077881,
-0.008660751,
0.0018784293,
0.018648969,
0.0034733221,
-0.014924331,
0.0056803958,
-0.011902089,
-0.026935967,
0.015929596,
-0.0042788237,
0.0042949338,
-0.012179181,
-0.013854625,
-0.027812352,
0.00088605157,
0.008183895,
-0.0036827524,
-0.0020475846,
0.03222006,
-0.02013109,
0.0020733606,
-0.0037407486,
0.015478515,
-0.018313881,
0.035699822,
0.013519536,
-0.033921275,
0.010465074,
-0.024203707,
0.019241817,
-0.035338957,
-0.00064762315,
-0.013841736,
-0.020285748,
-0.0027080958,
-0.014047945,
-0.0036956405,
-0.022077182,
0.0021136357,
0.0134293195,
-0.01739883,
-0.014279929,
-0.0041434993,
0.026832864,
-0.021522997,
0.036833968,
0.040313736,
0.008982952,
0.0036601985,
0.016793093,
-0.011289908,
-0.016612662,
0.034771886,
0.0012694702,
-0.019976435,
-0.0025647164,
0.0025308854,
-0.014975882,
-0.017579263,
0.0065245614,
0.02835365,
-0.012185626,
-0.02025997,
-0.04327798,
0.01630335,
-0.0077263694,
0.020285748,
-0.0030109643,
-0.019435138,
0.021187909,
-0.0047556804,
0.02027286,
0.035622496,
-0.02788968,
0.026678206,
0.014589242,
0.008712303,
-0.021922527,
0.0013371323,
0.02221895,
0.020814156,
0.0005215622,
-0.012714034,
0.0041434993,
0.004053283,
0.019602682,
0.017218398,
-0.008544759,
-0.016573997,
-0.004633244,
0.030544614,
-0.0019815334,
-0.0067146597,
-0.0018542643,
-0.03461723,
0.015014546,
-0.0062957993,
0.007964798,
-0.029951764,
-0.017360166,
0.0206595,
-0.007487941,
0.044231694,
0.016316237,
-0.049309574,
0.008989396,
-0.002244127,
0.014086609,
0.0013242443,
-0.02477078,
0.016393565,
0.013841736,
-0.016857533,
0.03474611,
-0.0033605518,
-0.012913799,
-0.052557357,
-0.016921973,
0.010645507,
0.029565124,
-0.0123273935,
-0.007945466,
-0.024461467,
0.027683472,
0.042530473,
0.013074899,
0.0065664477,
-0.003888961,
0.00041604147,
0.0032832238,
0.009343816,
0.0027419268,
-0.015504291,
0.008286999,
-0.025080092,
-0.008183895,
-0.0027080958,
0.029281588,
-0.00808079,
-0.0058962703,
-0.0020894706,
0.0055225175,
0.0121276295,
0.006154031,
0.008828295,
-0.0200151,
0.0139963925,
0.032039624,
-0.0007229375,
-0.031137463,
0.030080644,
-0.017373055,
-0.008602755,
-0.020917261,
0.02027286,
0.019074274,
0.017514823,
0.015259419,
0.0021651878,
0.017682368,
-0.0067791,
0.0025067204,
0.04111279,
-0.008261222,
-0.0059446003,
-0.02196119,
-0.02698752,
-0.005770612,
-0.0008554425,
-0.038174324,
-0.019886218,
-0.020968813,
0.03154988,
0.026575103,
0.0118956445,
-0.0031575656,
0.004443146,
-0.0088927355,
0.032116953,
-0.019731563,
-0.023804178,
-0.003402438,
0.0009593522,
-0.0035119862,
0.020375963,
-0.019963548,
-0.009582245,
-0.0005839885,
-0.007487941,
0.030106422,
-0.009872225,
0.018636081,
0.017669478,
0.011257688,
-0.010091322,
-0.061037675,
-0.0077714776,
0.004017841,
-0.0048072324,
0.03577715,
0.015439851,
-0.017437495,
0.06536805,
0.013165115,
-0.030931255,
0.025260525,
-0.010619731,
0.01283647,
0.008815408,
-0.0016408063,
0.038741395,
-0.02274736,
0.0070819682,
-0.006273245,
0.002298901,
-0.02332732,
-0.011109475,
-0.008093678,
-0.010432854,
0.006882204,
0.012140517,
-0.004062949,
0.017643703,
0.0041563874,
-0.0076748175,
0.009852894,
-0.026910191,
0.0016383899,
0.02763192,
-0.013377767,
0.009762677,
-0.026471999,
0.005667508,
0.022515375,
-0.03492654,
-0.026046693,
0.004974777,
0.0036634204,
-0.004568804,
-0.013197335,
-0.0006274856,
0.021071916,
-0.0059510446,
0.031240568,
-0.029255811,
-0.025595613,
-0.0065374495,
-0.018210776,
0.004910337,
-0.013931952,
-0.012372502
] |
Trefoil factor family 1 (TFF1) is a member of the TFF-domain peptide family involved in epithelial restitution and cell motility. Recently, we screened Piezo1 as a candidate TFF1-binding protein. We aimed to confirm Piezo1 as a novel TFF1 binding protein and to assess the role of this interaction in mediating gastric cancer cell mobility. This interaction was confirmed by co-immunoprecipitation and co-localisation of TFF1 and Piezo1 in GES-1 cells. We used stable RNA interference to knockdown Piezo1 protein expression and restored the expression of T | [
-0.020692514,
-0.01037361,
-0.0021130163,
-0.017205013,
0.015987806,
0.005125261,
-0.025657078,
0.004749158,
-0.017847806,
-0.03353473,
0.030963551,
0.006742505,
0.02891208,
0.009156404,
-0.02393384,
-0.023687664,
0.0054193055,
-0.012650744,
-0.006325372,
-0.0001992706,
-0.0065134238,
0.009621404,
-0.031674728,
-0.0383215,
-0.027585462,
0.020610455,
0.006981843,
-0.02669649,
-0.015003099,
-0.015085158,
0.017122954,
-0.003531951,
-0.012972142,
0.0065954826,
-0.019242808,
-0.0173281,
-0.003473826,
-0.0046910327,
0.028118843,
-0.011864346,
0.041603852,
-0.00062398944,
-0.0042191944,
0.009416257,
-0.018545307,
0.006797211,
0.016548542,
0.007316917,
-0.015481776,
0.01783413,
-0.0017984572,
-0.0077682408,
-0.007747726,
-0.0136217745,
-0.0018634205,
-0.009457286,
0.021089133,
0.00944361,
-0.006975005,
-0.017423837,
-0.013430304,
0.0074741966,
-0.02184134,
-0.010483022,
0.007959711,
0.01538604,
0.006352725,
0.01884619,
0.01962575,
-0.003928569,
0.021950752,
0.034601495,
-0.014852658,
-0.020842956,
0.04302621,
-0.032960318,
-0.021690898,
0.006998939,
-0.0068792696,
0.014907364,
0.0068074684,
0.0019095786,
-0.011091625,
0.018750455,
0.0028361601,
-0.011105302,
-0.011789126,
0.023879135,
-0.008075962,
0.017396484,
0.02230634,
0.027421344,
-0.0036789733,
0.010941184,
-0.00835633,
0.005809085,
-0.019297514,
0.007255373,
0.014893687,
-0.036133263,
-0.006369821,
0.0045405915,
0.0031558478,
-0.0067835343,
-0.018586338,
-0.013751701,
0.018928248,
0.002731877,
-0.0011727582,
-0.017150307,
-0.045022976,
0.025821196,
-0.006154416,
-0.029978845,
0.017902512,
-0.004178165,
0.02047369,
0.0254109,
-0.021485751,
-0.010701846,
0.024768107,
0.014360305,
0.0081375055,
-0.032112375,
0.044749442,
0.008629859,
0.0010342839,
-0.0021728508,
0.0030293404,
-0.0020343764,
0.0033507377,
0.0161656,
0.03131914,
0.01620663,
-0.02245678,
-0.015249276,
-0.026340902,
-0.015810011,
-0.014209863,
-0.011987435,
0.012835377,
0.018312808,
-0.011419862,
-0.016056187,
0.0080075795,
0.016726336,
0.023017516,
0.0044072457,
0.014838981,
0.013279863,
0.00012992657,
-0.007898168,
-0.0101547865,
0.0155364815,
0.0037200027,
0.014168833,
-0.008034932,
0.013088392,
-0.016097218,
-0.034191202,
-0.035066497,
0.013437142,
0.011324126,
0.006725409,
0.025096342,
0.038376205,
0.009730816,
0.010578758,
-0.0040516574,
-0.00983339,
-0.0063458867,
-0.008130668,
-0.029076198,
-0.00036199935,
-0.0053611803,
-0.013231995,
-0.004020885,
0.019475307,
-0.00707074,
-0.0024857004,
-0.02300384,
0.025780166,
0.004803864,
-0.000847087,
-0.005771475,
-0.02304487,
0.013512363,
0.0042499662,
-0.021458399,
-0.035996497,
-0.006889527,
-0.0005714205,
0.025985314,
0.00010284072,
-0.62014633,
-0.021540457,
0.027079431,
-0.0071801525,
-0.0060450044,
0.029595904,
-0.0061065485,
-0.018941926,
-0.028857375,
0.01185067,
-0.016548542,
0.025698107,
-0.01861369,
-0.00094795105,
-0.021882368,
-0.019420601,
-0.024043253,
-0.030416492,
0.012274642,
0.027448697,
-0.010804419,
0.016288688,
-0.00637324,
0.042150915,
0.02669649,
0.024467224,
0.018709425,
-0.028447079,
-0.022388399,
0.018340161,
-0.018490601,
0.0072143436,
-0.014538099,
-0.0005705657,
0.04037297,
-0.0064416225,
-0.0026241748,
0.014715893,
0.011118978,
0.035887085,
-0.027722226,
0.011891699,
0.008000741,
-0.004841474,
-0.028830022,
0.007009196,
0.00034896395,
0.0073237554,
0.0052757026,
-0.0040619145,
-0.0065407767,
0.0042260326,
-0.033890318,
0.011324126,
0.033261202,
0.013320892,
0.04329974,
-0.03555885,
0.0037918042,
-0.0024668952,
-0.0019181264,
0.004386731,
0.006715152,
0.0073852995,
0.016452806,
0.0002436123,
0.0046226503,
0.028228255,
0.013300377,
0.012671259,
0.013457657,
0.013977363,
0.005087651,
0.0016873358,
0.021225898,
0.06263828,
-0.011980597,
0.030498551,
0.002436123,
0.0034327966,
0.008212727,
0.011932729,
-0.006913461,
0.0011941277,
0.002948991,
0.013991039,
-0.016288688,
0.045952976,
0.017929865,
-0.009594051,
0.013081553,
0.003427668,
-0.0075836084,
-0.034875024,
-0.020145455,
0.008424712,
-0.015139864,
0.0025318584,
0.028966786,
-0.030060904,
-0.0007722938,
-0.040044736,
0.03427326,
-0.0101547865,
-0.0014394496,
-0.0042739003,
-0.014442364,
0.01332773,
0.031291787,
-0.027612815,
-0.0066296738,
0.003135333,
-0.006253571,
-0.025780166,
-0.00040559313,
-0.029103551,
0.034683555,
0.023113253,
0.005915078,
-0.026614431,
0.0072895642,
-0.014510746,
0.03271414,
0.008110153,
0.02467237,
0.02891208,
0.0028224837,
-0.0006372385,
-0.0040037897,
-0.018039279,
0.0027865828,
0.010551405,
0.021786634,
-0.014127804,
0.0074741966,
0.0128969215,
0.0119395675,
0.014004716,
0.008294785,
-0.021636192,
-0.018353837,
-0.014305599,
0.005067136,
-0.031674728,
-0.0256434,
-0.010777066,
-0.00804177,
-0.0041952603,
0.03408179,
-0.014934717,
0.039771207,
0.0015377493,
-0.00019691995,
0.01131045,
0.029431786,
-0.0045679444,
-0.027530756,
-0.019242808,
0.00796655,
-0.03085414,
0.0019608655,
-0.005692835,
-0.032550022,
-0.02638193,
0.004239709,
-0.011919052,
0.013245671,
-0.033753555,
0.0007107496,
-0.038868558,
0.009867581,
-0.01589207,
-0.017423837,
0.03131914,
-0.015399717,
0.034984436,
0.0071596378,
0.0081375055,
-0.007870815,
-0.024973253,
-0.022019133,
-0.024768107,
-0.013122583,
0.008985448,
0.03629738,
0.013437142,
0.023537222,
0.020063397,
-0.014852658,
0.04931739,
-0.02899414,
-0.0050842315,
-0.024262076,
0.015085158,
-0.016001482,
-0.019748839,
0.024863841,
-0.0064347843,
-0.015030452,
0.02638193,
0.013218318,
-0.013478171,
0.012616553,
-0.018586338,
0.013136259,
-0.01224045,
-0.017806778,
-0.026450314,
0.0062125414,
0.03353473,
0.002036086,
-0.0052962173,
-0.028009431,
0.0017052862,
-0.014784276,
0.0084725795,
0.017205013,
0.0002786583,
-0.01741016,
-0.018873543,
-0.018600013,
0.010394125,
0.016657954,
0.016849425,
-0.019735161,
0.0055970997,
0.0041713268,
0.0065305196,
-0.0004359378,
-0.020268545,
-0.004752577,
0.024412518,
0.018189719,
0.0235509,
0.0050739744,
0.014606481,
0.03175679,
-0.004205518,
0.036817085,
0.010120596,
-0.0007975098,
0.012712289,
-0.007939197,
0.0017146887,
-0.0023301304,
0.0008060576,
0.01962575,
-0.011529273,
-0.0018223911,
0.02891208,
0.002005314,
0.030443845,
-0.028419726,
-0.0028686419,
0.00707074,
-0.008677727,
-0.0072964025,
0.012739642,
0.023865458,
0.0062467325,
0.017218689,
-0.00893758,
-0.0061407397,
-0.008287948,
-0.012144715,
-0.0001711697,
0.012131038,
-0.011919052,
-0.018654719,
-0.004838055,
-0.032002963,
0.0066228355,
0.017081924,
-0.016972512,
0.0049679815,
0.013970525,
0.0011607913,
0.011932729,
0.00021989216,
0.0051081656,
-0.015454423,
-0.043245032,
0.02249781,
0.011754935,
-0.0063561443,
-0.021130163,
-0.015905747,
0.029212963,
0.01196692,
0.0123019945,
0.025848549,
0.025274135,
0.023263693,
0.0065681296,
-0.006749343,
0.007549417,
0.0138816275,
-0.022019133,
0.0053953715,
0.0003555885,
-0.00083982135,
-0.014209863,
-0.023605606,
-0.005586842,
0.043463856,
0.0008231532,
-0.008315301,
-0.0026703328,
0.0018394866,
-0.019488985,
0.007747726,
-0.0020959207,
0.012958465,
-0.00392515,
0.0030823369,
-0.0037507748,
0.0060142325,
-0.003668716,
0.038950615,
-0.009190595,
-0.020692514,
-0.031346492,
0.002024119,
0.008452065,
0.016794719,
0.05377592,
0.0061065485,
0.0022275567,
-0.0006214251,
0.03602385,
-0.011207876,
-0.031127669,
0.008294785,
-0.013396112,
0.00005454565,
-0.0024395422,
0.006578387,
-0.0016420324,
-0.0065920637,
0.020295897,
-0.0032379068,
-0.035969142,
0.014168833,
0.0054842685,
-0.0010368482,
0.003949084,
0.027681196,
0.016042512,
0.0031678148,
-0.015550158,
0.0044619516,
0.0549521,
-0.0022395237,
-0.01608354,
-0.0030395978,
0.005699673,
0.0016702402,
-0.0008949547,
-0.038294144,
-0.031975612,
0.014524423,
-0.005809085,
-0.0004500417,
0.00983339,
-0.024193695,
0.012384053,
-0.006462137,
-0.007433167,
0.007542579,
-0.0032430354,
0.00022138802,
0.00013847437,
-0.012185744,
-0.003272098,
0.0011360027,
-0.020733545,
0.016151924,
-0.013573907,
0.0071117696,
-0.0101547865,
-0.010353096,
-0.018326484,
-0.0038909586,
-0.025123695,
-0.01492104,
-0.028200902,
-0.008650374,
-0.015673246,
0.02965061,
-0.025246782,
0.0067083137,
-0.039470322,
-0.009771845,
-0.010674493,
0.018271778,
-0.03711797,
-0.03676238,
-0.014442364,
-0.007433167,
0.0034020245,
0.004376474,
-0.0096897865,
0.007364785,
0.0024822813,
0.010277875,
-0.018777808,
-0.01519457,
-0.025233107,
-0.014059422,
0.0044277604,
-0.003232778,
-0.012766995,
0.011611332,
-0.0126644205,
0.024193695,
-0.004017466,
0.022347368,
-0.023728693,
-0.014401334,
0.007508388,
0.014415011,
0.0133619215,
-0.01916075,
0.027640168,
-0.006034747,
-0.035449438,
0.023195311,
-0.025848549,
-0.0074400054,
0.011091625,
0.025479283,
0.015604864,
-0.012732803,
0.007166476,
-0.00067442143,
0.014674864,
0.0034840833,
0.013991039,
0.016110893,
0.0093273595,
-0.010824935,
0.006520262,
-0.02040531,
-0.0077887555,
-0.0059732026,
0.016452806,
0.03566826,
-0.0073237554,
-0.0077955937,
0.011583979,
0.001678788,
-0.021348987,
-0.010770229,
-0.00051115843,
-0.008841844,
0.037747085,
0.013779054,
-0.006687799,
-0.015509129,
-0.015098834,
-0.02032325,
0.004677356,
-0.0049748197,
-0.015563834,
-0.027106784,
0.0040892675,
0.017587954,
-0.007569932,
-0.00036755542,
-0.0256434,
-0.0016659662,
0.0012026755,
0.0017249461,
0.017437512,
-0.018805161,
0.014866334,
-0.008144344,
-0.011077949,
-0.02452193,
-0.025424577,
-0.025684431,
-0.024316782,
0.026395608,
0.019393248,
0.042697974,
0.028693257,
-0.002366031,
0.008089638,
0.0044277604,
0.003415701,
-0.008923903,
0.011898538,
-0.0044072457,
0.04275268,
0.018435895,
-0.017040895,
0.03410914,
-0.0072690495,
0.018435895,
0.02296281,
-0.016028835,
-0.005470592,
0.0108522875,
-0.026217813,
-0.018928248,
0.0013821793,
-0.012466112,
0.012418244,
-0.016233983,
0.00088213297,
-0.016548542,
0.012479789,
-0.0020070234,
0.015905747,
0.018723102,
-0.0010924089,
0.033671495,
-0.010134272,
0.017095601,
-0.012924274,
-0.028447079,
0.005778313,
-0.017943542,
0.013943172,
-0.012555009,
0.016507512,
0.000018658246,
-0.01907869,
-0.0121994205,
0.0074400054,
-0.0047730915,
-0.017273394,
-0.009129051,
-0.0059458497,
-0.03834885,
-0.030662669,
-0.0081375055,
-0.049098566,
-0.004260224,
-0.0044858856,
-0.031428553,
0.011583979,
0.023851782,
-0.005798828,
0.031674728,
0.0076725055,
0.043463856,
0.008397359,
0.023099575,
0.014291923,
-0.0076793437,
-0.0073852995,
0.008301624,
0.009217948,
-0.0036379439,
0.026026342,
0.025287813,
0.002066858,
-0.024097959,
0.0019523175,
0.0010736038,
-0.024166342,
-0.029513845,
0.018982954,
-0.0018736778,
0.005549232,
-0.0050773933,
-0.0036174292,
-0.009101698,
0.018189719,
-0.0031678148,
-0.0028122263,
-0.010722361,
-0.0043149297,
-0.026737519,
0.010558243,
-0.0063971737,
0.0072690495,
-0.0150714815,
0.0035490466,
0.011768611,
-0.034875024,
-0.0043388633,
0.0095872125,
-0.007310079,
0.021950752,
-0.004133716,
0.028118843,
0.008616183,
0.0010035117,
-0.0053919526,
-0.019680455,
-0.002988311,
0.042807385,
-0.020692514,
0.0044311797,
0.0005444949,
-0.007932358,
0.004841474,
-0.035066497,
-0.010134272,
-0.0048859227,
-0.029705316,
-0.01884619,
0.0323312,
0.0006543341,
-0.021499427,
0.00025493815,
-0.019639427,
-0.008609344,
-0.033589438,
-0.017970895,
0.0050261067,
-0.04800445,
-0.010674493,
0.002179689,
0.05276386,
0.024426194,
0.009115375,
-0.012937951,
-0.015864717,
0.035066497,
-0.034027085,
0.0012924274,
0.004403827,
-0.0074673584,
-0.031373847,
-0.0020925016,
-0.010592435,
-0.014852658,
0.0108796405,
-0.03435532,
0.0032567119,
-0.008971771,
-0.0101547865,
0.03906003,
0.017013542,
-0.020350603,
0.015345011,
0.024412518,
0.009156404,
0.004232871,
0.005915078,
0.011481405,
-0.00435254,
0.003586657,
0.019707808,
-0.010736037,
-0.0009958188,
0.0068348213,
-0.015577511,
0.000115822695,
0.0032361972,
-0.028665904,
-0.022443105,
-0.028228255,
-0.037172675,
-0.019010307,
-0.008205888,
-0.001523218,
-0.004632908,
0.007392138,
-0.015823688,
-0.022155898,
-0.021007074,
0.0143192755,
0.017765747,
-0.0030413074,
-0.030471198,
-0.030197669,
0.006092872,
-0.025383547,
-0.009717139,
-0.011782288,
-0.019119719,
0.022142222,
-0.005699673,
-0.027024725,
0.0042739003,
0.010086404,
-0.029295022,
-0.026682813,
-0.020952368,
0.0066946372,
-0.0016292108,
0.002805388,
-0.030826787,
0.012048979,
-0.00951883,
0.01270545,
-0.002420737,
-0.020842956,
0.010975376,
-0.011426699,
0.0012394311,
-0.031291787,
-0.039388265,
-0.030142963,
0.031428553,
-0.00032652597,
0.0015839074,
0.019256484,
-0.016630601,
0.010701846,
-0.00796655,
0.009744492,
0.0038294145,
0.01741016,
0.024125312,
-0.010537729,
-0.017027218,
-0.0017198174,
0.013170451,
-0.015331334,
-0.004438018,
0.007316917,
0.0036174292,
0.010161625,
0.002490829,
-0.02623149,
0.02781796,
-0.018394867,
0.037282087,
0.00843155,
-0.0011411314,
0.0005962091,
0.026204137,
0.0093273595,
-0.03304238,
-0.013006333,
-0.021663545,
0.013013171,
0.028747963,
-0.008787138,
-0.01395001,
-0.010038537,
0.006571549,
-0.016808394,
0.008739271,
-0.010435155,
-0.0141141275,
-0.034519438,
0.013437142,
0.022798693,
0.0029695057,
-0.030142963,
-0.004321768,
-0.011830156,
-0.03282355,
-0.008944418,
-0.011679715,
-0.01994031,
-0.026272519,
-0.0008915356,
-0.014373981,
0.0028925757,
-0.0045850403,
0.0050910697,
0.006270666,
0.018080307,
0.20000485,
-0.020542074,
-0.0063287914,
0.006270666,
-0.0070433873,
0.00060646643,
0.009183757,
-0.011693391,
-0.0006376659,
0.0012257546,
0.012739642,
0.0019266742,
0.002957539,
-0.0027506822,
-0.0049303714,
-0.012931112,
-0.035722967,
-0.0002737433,
-0.034191202,
0.014442364,
0.0029848919,
-0.027188843,
0.02817355,
0.013649127,
0.028802669,
-0.0022976487,
-0.021116486,
-0.019406926,
0.024549283,
0.008062285,
-0.020911338,
-0.0034618592,
0.0003348601,
0.020719867,
-0.010243684,
0.020706192,
-0.004403827,
-0.00068553357,
0.012883245,
-0.01496207,
-0.02684693,
-0.012288318,
-0.02728458,
-0.008034932,
-0.002051472,
-0.0058466955,
-0.010941184,
0.015413393,
0.012076332,
0.006174931,
-0.045487974,
0.0028703513,
0.020418985,
0.00843155,
-0.00015257824,
-0.018517954,
0.03684444,
0.015905747,
-0.015345011,
0.007781917,
0.011207876,
0.011905376,
-0.040783264,
0.024371488,
-0.013505525,
0.014880011,
-0.0045679444,
0.011399346,
0.012083171,
-0.016781041,
0.0029900204,
0.0038088998,
-0.010715523,
0.01907869,
-0.030197669,
-0.025547666,
0.028802669,
-0.010777066,
0.021663545,
0.051368862,
0.0076793437,
-0.0062501514,
-0.02872061,
0.0052962173,
-0.010626625,
-0.020678839,
0.026149431,
-0.0011240357,
-0.018080307,
-0.020460015,
0.010790743,
0.00012458418,
-0.008445227,
-0.0034926313,
0.011371993,
-0.010011184,
-0.02199178,
0.0065578725,
-0.0014232087,
-0.0036345248,
-0.03482032,
0.043080915,
0.0028002593,
0.014715893,
-0.021225898,
0.0032498736,
-0.006349306,
0.010695008,
0.027270902,
-0.018668396,
-0.010968537,
-0.009915449,
0.021307956,
-0.0058398573,
0.0060791955,
0.0024309943,
-0.002762649,
-0.0008992286,
0.035340026,
-0.029513845,
0.01286273,
-0.019830897,
0.02965061,
0.015509129,
-0.03271414,
0.010633464,
-0.017191336,
-0.012773833,
0.010551405,
-0.042424444,
-0.00095137017,
0.0044551133,
0.005497945,
0.009532507,
0.010380449,
-0.0029900204,
0.014155157,
0.02382443,
-0.017095601,
0.0123567,
-0.004448275,
-0.0032618407,
-0.01006589,
0.028009431,
-0.038184732,
-0.0065065855,
0.034027085,
-0.0008244353,
-0.016069865,
-0.026258843,
-0.010640302,
-0.0126917735,
-0.0054295626,
-0.0064416225,
0.020159133,
-0.021964427,
-0.018818837,
-0.03271414,
0.030416492,
0.00361401,
-0.031975612,
0.0014240636,
0.0127943475,
-0.018052954,
-0.010811258,
-0.010859125,
-0.17352718,
0.021868693,
0.013963686,
-0.011768611,
0.052326214,
0.010701846,
0.0061920267,
-0.0051697097,
0.008370006,
0.0045918785,
0.028036784,
0.001142841,
-0.0024839907,
-0.025287813,
0.0148116285,
0.011050596,
-0.03399973,
0.0068519167,
0.015796335,
0.024166342,
0.01177545,
-0.008260595,
0.019270161,
0.015591187,
0.005532136,
0.023140606,
0.008554638,
-0.01981722,
-0.00009172858,
0.0054227244,
0.0048277974,
-0.004181584,
0.04275268,
0.0011556626,
0.021116486,
-0.014784276,
0.015960453,
-0.01931119,
0.012233612,
0.033288553,
0.03845826,
0.028474431,
0.010175302,
-0.0040516574,
-0.020911338,
0.014004716,
-0.0090948595,
-0.023195311,
0.037856497,
0.0040037897,
0.008547801,
-0.025711784,
0.018463248,
0.01515354,
0.014291923,
-0.0042568045,
-0.000018364415,
0.0035422083,
0.0054534967,
-0.023113253,
-0.008445227,
-0.0017967477,
0.048059154,
-0.020309573,
-0.0030908845,
-0.022607222,
-0.0074194907,
0.001741187,
-0.025233107,
0.0043696356,
-0.021608839,
-0.0024378328,
0.02405693,
-0.005682578,
0.01783413,
0.015686924,
-0.010954861,
0.00085862656,
0.0020617296,
0.011495082,
0.010729199,
-0.010045375,
0.0012616554,
-0.022060163,
0.02342781,
-0.013375598,
-0.008971771,
0.016972512,
-0.013061039,
-0.0096897865,
0.02428943,
-0.013943172,
0.011125817,
-0.01224045,
0.025793843,
0.029431786,
-0.0026087887,
0.0027028145,
-0.027790608,
-0.008246918,
0.017259719,
-0.008110153,
-0.0031028516,
0.021362662,
0.041713264,
0.017984571,
-0.026149431,
0.008028094,
0.04209621,
-0.012678097,
-0.015823688,
-0.012117362,
0.022743987,
0.0143192755,
-0.018080307,
0.04866092,
0.020760898,
0.012315671,
0.009826551,
-0.02304487,
0.07035182,
0.0006534793,
0.023291046,
0.014524423,
-0.022073839,
-0.015180893,
-0.10777067,
0.006769858,
0.022607222,
0.007316917,
-0.01745119,
0.0057407026,
-0.00008510404,
0.008773462,
-0.013669643,
0.038294144,
0.0020258287,
-0.016726336,
-0.0018480344,
-0.025602372,
0.0025506637,
0.010483022,
0.01367648,
-0.007665667,
-0.032932963,
0.02735296,
-0.014360305,
0.010736037,
0.01173442,
-0.00014573999,
0.009204271,
-0.002661785,
-0.019516338,
0.01565957,
0.008575154,
0.0054774303,
0.013293539,
-0.0040892675,
0.032112375,
-0.007091255,
-0.017314425,
-0.01620663,
0.012336185,
-0.02817355,
0.022402074,
-0.008028094,
-0.014373981,
0.0012060946,
-0.0048790844,
-0.0044961427,
-0.01810766,
-0.015030452,
-0.014866334,
0.0235509,
0.042315032,
-0.024070606,
-0.021431046,
-0.040318266,
-0.035340026,
-0.017492218,
0.03788385,
-0.01888722,
0.000744086,
0.018162366,
-0.009888096,
-0.0069271373,
-0.029787375,
0.00065091497,
0.0006457863,
0.011830156,
0.024904871,
0.0247134,
0.00835633,
-0.02665546,
0.023564575,
-0.012377215,
-0.0072416966,
-0.00008473007,
-0.02164987,
-0.0024668952,
-0.034191202,
-0.009313683,
-0.020692514,
-0.0016651115,
0.02945914,
-0.03438267,
-0.015686924,
-0.031291787,
0.015098834,
-0.013204642,
0.04737533,
0.009888096,
0.038950615,
0.0008778591,
0.009231624,
-0.015604864,
-0.028228255,
0.040509734,
0.019885603,
0.009703463,
-0.029103551,
0.016958836,
-0.007747726,
0.006636512,
0.013690157,
0.01472957,
-0.03807532,
-0.019953985,
-0.077080645,
0.01966678,
-0.020309573,
-0.012021626,
0.020760898,
0.013307216,
0.023099575,
0.021198545,
-0.0018258102,
0.010783905,
-0.007836623,
0.013662804,
0.0025985313,
-0.015481776,
-0.017943542,
-0.0013650837,
0.046527386,
-0.00074707775,
0.025561342,
0.024973253,
-0.0048448932,
0.0254109,
0.011891699,
0.011002729,
-0.008869197,
-0.017109277,
-0.022237957,
0.010954861,
-0.004410665,
0.020200161,
-0.005774894,
-0.026669137,
-0.010052213,
-0.011871185,
-0.0065920637,
-0.0139842015,
-0.012459273,
0.014346628,
0.013409789,
0.011125817,
-0.0042260326,
-0.026942667,
0.005727026,
-0.007166476,
0.013587584,
-0.0039969515,
-0.019092366,
-0.008923903,
0.009511992,
0.0046636797,
0.016151924,
0.0050910697,
0.016179277,
0.0041952603,
-0.005241511,
-0.006964748,
0.02766752,
-0.020952368,
-0.0052449303,
-0.012883245,
0.024508253,
0.038950615,
-0.0016967384,
-0.0005346649,
0.0020155713,
0.009628242,
-0.032577377,
-0.020692514,
0.013943172,
-0.035340026,
-0.036981203,
0.0031387522,
0.0011522435,
0.021896046,
0.03011561,
0.00804177,
-0.029787375,
-0.0025711784,
-0.0068416595,
0.03244061,
0.0029250572,
-0.021116486,
-0.0043730545,
0.0034789548,
0.02716149,
-0.0026344322,
-0.010592435,
0.019393248,
0.00893758,
0.008643536,
-0.010804419,
0.0121242,
0.004208937,
-0.0020566008,
0.0045303344,
-0.0017052862,
0.008171697,
0.024043253,
0.015180893,
0.021677222,
-0.010127434,
-0.010742876,
-0.00757677,
-0.005398791,
-0.015262952,
0.0013685029,
-0.024562959,
-0.025616048,
-0.01515354,
-0.011638685,
0.013108906,
0.014018392,
-0.0064245267,
-0.0009257268,
-0.0073032407,
-0.0068621743,
-0.014825305,
0.0074058142,
-0.0060757766,
0.04554268,
0.009614565,
0.007508388,
0.0070570637,
-0.011925891,
0.027503403,
0.011077949,
0.028310314,
0.0009496606,
0.030662669,
-0.022278987,
0.022361046,
0.0006547615,
-0.0091974335,
-0.024973253,
0.0053304085,
-0.002817355,
-0.024686048,
0.011891699,
-0.025096342,
0.098415956,
0.008445227,
-0.008458903,
-0.017970895,
-0.001414661,
0.0055629085,
-0.0010291551,
0.010551405,
-0.008746109,
-0.054487098,
0.0011744677,
-0.02513737,
-0.013553392,
-0.0038191571,
-0.013416627,
0.008376844,
-0.006715152,
-0.010113757,
-0.017040895,
-0.008759785,
0.0025438254,
-0.020186486,
-0.013382436,
0.016644277,
-0.024822813,
0.009361551,
0.025506636,
0.020159133,
-0.004581621,
-0.026682813,
0.0025438254,
-0.010592435,
-0.026559725,
-0.012308832,
0.028146196,
-0.0127943475,
-0.022046486,
-0.004687614,
0.025356194,
0.03845826,
-0.021964427,
0.01608354,
-0.00858883,
0.005039783,
0.0043696356,
-0.00002778035,
0.019803545,
-0.006636512,
-0.03205767
] |
Glycosyl phosphatidylinositols (GPIs) anchor many proteins to the surface of eukaryotic cells and may also serve as sorting signals on proteins and participate in signal transduction. We have isolated a Saccharomyces cerevisiae GPI anchoring mutant, gpi1, using a colony screen for cells blocked in [3H]inositol incorporation into protein. The gpi1 mutant is defective in vitro in the synthesis of N-acetylglucosaminyl phosphatidylinositol, the first intermediate in GPI synthesis, and is also temperature-sensitive for growth. Completion of the first | [
-0.028033981,
-0.02282614,
0.0048631057,
-0.024968183,
-0.026373899,
0.012591193,
-0.02037618,
0.019037403,
0.0021654712,
-0.022250466,
0.04201081,
0.010121151,
-0.012725071,
0.026628267,
-0.005435433,
-0.003922615,
0.022277242,
0.0024700428,
-0.023334876,
0.020295853,
-0.034004927,
0.0045953505,
-0.0051609837,
-0.027096838,
0.017926218,
0.011178784,
0.006566699,
-0.025329653,
-0.021380262,
-0.01653389,
0.0058839233,
-0.01498091,
-0.01593144,
0.010696825,
-0.0017755524,
-0.027873328,
0.015074625,
0.00584376,
-0.0013638786,
0.004799514,
0.0070486586,
0.008059435,
-0.0054521677,
0.012832173,
-0.011031519,
0.01977373,
-0.021340098,
0.0053952695,
-0.009953803,
0.02044312,
0.004909963,
-0.0044982894,
-0.011406376,
-0.014485562,
-0.018006545,
-0.025825,
-0.002460002,
-0.010736988,
-0.0057333107,
-0.018555444,
-0.0072896383,
-0.0098333135,
-0.02300018,
0.014579277,
0.00633576,
0.01756475,
0.008548088,
-0.006389311,
-0.016373238,
-0.008768987,
0.039681338,
0.032666147,
-0.008876089,
-0.0036448191,
0.015717236,
-0.022344181,
-0.039520685,
-0.018207362,
-0.020081649,
0.025423367,
0.018461728,
-0.006811026,
-0.0034573905,
0.021634629,
0.0022842875,
0.017537974,
0.018113647,
0.014646215,
0.009659273,
0.0059675965,
0.037994478,
0.042465992,
0.013628745,
0.013039684,
-0.025195776,
0.010455845,
-0.016453564,
0.012095846,
-0.00082209246,
-0.02025569,
0.0053484123,
0.013193643,
0.008387435,
-0.018207362,
-0.019211443,
0.007544006,
0.009284415,
-0.024405897,
0.019680016,
0.0007472047,
-0.008347272,
0.038797744,
0.016520502,
-0.02732443,
0.022879692,
-0.009337966,
0.025771448,
0.015971605,
-0.0072762505,
-0.0008785721,
0.021741731,
0.02223708,
0.027578797,
-0.0051208204,
0.01701585,
0.019505974,
-0.010944499,
-0.00031126555,
-0.010716907,
-0.0046555954,
0.020523446,
0.024954796,
-0.006064658,
0.016159033,
-0.00045518402,
-0.016694544,
-0.022960018,
0.0013546746,
-0.0040765745,
-0.046830405,
0.006496413,
0.02061716,
-0.02127316,
0.004802861,
-0.00034264312,
0.0001694389,
0.021366874,
0.019854056,
0.008748905,
0.0075908634,
0.01558336,
0.012611276,
0.024405897,
-0.0049902895,
0.0030825331,
0.042867627,
-0.023642795,
0.024312183,
-0.0026373898,
-0.01360197,
-0.011787928,
-0.012142704,
-0.010556254,
-0.0010885927,
0.00036481663,
0.034353007,
-0.0084275985,
0.017591525,
-0.008514619,
-0.00039640337,
-0.0021504099,
0.013936664,
-0.02851594,
0.031568352,
-0.01839479,
0.009384824,
0.0035209823,
0.012832173,
-0.014418623,
-0.014579277,
-0.0021386957,
0.0072628628,
0.0066035152,
0.000828368,
-0.013816174,
-0.009719518,
0.02996182,
0.004970208,
0.01201552,
-0.022076426,
-0.012002132,
0.0067976383,
-0.00079364347,
-0.008467762,
-0.6400423,
-0.018434953,
0.03363007,
-0.022103202,
0.028783696,
0.038663868,
0.019305158,
-0.00063508213,
-0.0043075136,
0.028435614,
-0.011178784,
-0.00082460267,
-0.000039117378,
-0.010107763,
-0.026414061,
-0.02846239,
0.015288829,
-0.023629406,
0.03239839,
0.003146125,
-0.02660149,
0.0026825736,
0.008789068,
0.028810471,
0.0302028,
0.012778622,
0.024914632,
-0.038610317,
-0.039279703,
0.039895542,
-0.015355768,
0.022665488,
-0.030015372,
0.004799514,
0.04972216,
0.004230534,
-0.012805398,
0.01953275,
0.025450142,
0.050230898,
-0.015382543,
-0.017511198,
0.012022214,
0.00743021,
-0.016466951,
0.019198056,
-0.00018240832,
0.002627349,
0.0044280034,
-0.023227774,
-0.0044949423,
-0.00706874,
-0.03199676,
0.017872667,
-0.003594615,
0.005666372,
0.010716907,
-0.00292188,
0.03810158,
0.013588582,
0.006155025,
0.0132070305,
-0.015529809,
-0.022063037,
-0.0031729005,
0.0017127973,
-0.018167198,
0.01351495,
0.004096656,
-0.012269887,
0.03494207,
0.005150943,
-0.016400013,
0.018622382,
-0.021728344,
0.023441978,
0.0018040014,
0.018863361,
-0.013200337,
0.0051275142,
0.005696494,
-0.006392658,
-0.020643935,
0.0032883699,
0.017966382,
0.013950052,
-0.011038213,
0.020001322,
0.0063759233,
-0.014820256,
0.008722129,
-0.00194792,
0.0006873781,
-0.021875609,
-0.019238219,
0.013320827,
-0.017511198,
-0.01437846,
0.032987453,
-0.016025156,
-0.014432011,
0.0037318396,
-0.022732425,
-0.0006509801,
0.021581078,
-0.0033887783,
-0.023749897,
0.016654382,
0.03678958,
-0.034353007,
-0.0011931846,
-0.027070062,
0.002858288,
0.00023595938,
0.01162058,
-0.01929177,
0.050498653,
0.014338297,
-0.0069951075,
-0.016801646,
-0.0041535543,
-0.0039728195,
0.0034222477,
0.0019880831,
0.006794291,
0.010020743,
0.013153479,
-0.019184668,
-0.0027394716,
0.0068813115,
-0.008266945,
-0.0051743714,
0.009799845,
-0.0046522487,
0.0060512703,
0.026146306,
-0.006757475,
0.002520247,
0.013976827,
-0.03973489,
-0.033897825,
-0.013160174,
-0.000093295996,
-0.01120556,
-0.011600499,
-0.015007686,
-0.021433813,
-0.028141083,
0.019626465,
0.016507115,
0.016279522,
0.019572914,
0.0016810014,
0.012691602,
-0.006238699,
-0.02875692,
-0.016306298,
-0.015569972,
0.0017537973,
0.010643274,
-0.011560336,
0.006268821,
0.012403765,
-0.023495529,
-0.021594467,
-0.017993158,
0.013789399,
-0.006954944,
-0.016493727,
-0.022210304,
0.007778292,
-0.014097317,
-0.012992826,
0.005278127,
0.009083599,
0.046348445,
0.011513478,
0.017604912,
-0.010703519,
0.0004957657,
0.0046422076,
-0.03146125,
-0.021915773,
0.006111515,
0.02846239,
0.0062955967,
0.020041486,
0.021634629,
0.0036849824,
0.009752987,
-0.008012578,
0.0025905326,
-0.0013940011,
0.007818455,
-0.010556254,
-0.011392988,
0.0040163295,
-0.0108173145,
-0.01498091,
0.02540998,
0.038797744,
-0.02241112,
0.005201147,
-0.028649818,
0.021728344,
-0.021527527,
-0.0028984512,
-0.032184187,
-0.010496008,
0.00004539289,
0.02480753,
0.009398212,
0.0008300415,
0.006807679,
0.010147926,
-0.00917062,
-0.004183677,
0.0030808595,
-0.0064930664,
-0.0070486586,
-0.008608334,
0.0083405785,
0.017671851,
-0.003959432,
-0.0055793514,
0.00839413,
-0.007905476,
0.02923888,
-0.005987678,
-0.009967191,
-0.015891278,
0.004685718,
-0.00779168,
0.026588103,
0.01087756,
0.024312183,
0.027284266,
0.002769594,
0.06736724,
0.0036113497,
0.009163925,
0.031969983,
0.0047727386,
-0.0070553524,
0.0013287357,
-0.002339512,
0.03494207,
0.012209643,
-0.026306959,
0.0276859,
0.0059240866,
0.01905079,
-0.02606598,
0.0033569823,
0.009451763,
-0.0056764125,
0.02282614,
0.020992016,
0.015904665,
0.02277259,
-0.004176983,
-0.009056823,
-0.014083929,
-0.012751847,
0.009438375,
0.02444606,
0.00913715,
-0.0058671883,
-0.014458787,
0.024164917,
-0.012022214,
0.011607192,
-0.009619109,
-0.002627349,
0.0011630622,
0.0038188603,
0.013153479,
0.0049835956,
0.035263374,
-0.0033804108,
-0.019452423,
-0.029560186,
0.00645625,
0.022196915,
-0.016426789,
-0.022210304,
-0.022089813,
-0.006800985,
-0.012062377,
-0.008889477,
-0.018662546,
0.018140422,
0.009063518,
-0.018997239,
-0.0024499611,
-0.026266797,
0.014458787,
-0.020858139,
0.011259111,
-0.0003756942,
-0.0017688585,
0.005258045,
-0.007610945,
-0.010977968,
0.051569674,
0.0013772664,
-0.010141233,
0.00811968,
0.0038623705,
-0.03464754,
0.00937813,
-0.0031277167,
0.0021386957,
-0.027297655,
0.0022775936,
0.0073967404,
-0.0008505415,
-0.011607192,
0.021862222,
0.01099805,
-0.02037618,
-0.018796423,
-0.0063123317,
-0.0055726576,
0.023455366,
0.025503693,
0.00061541883,
0.018823199,
-0.0040732278,
0.010750376,
-0.0013362664,
-0.030604433,
0.009813232,
-0.019479198,
-0.006345801,
-0.002346206,
0.0075373123,
-0.016828422,
0.013340909,
0.019037403,
-0.008521313,
-0.028676594,
0.02594549,
-0.0043209014,
0.02589194,
-0.016627604,
0.0047024526,
0.032371618,
0.013749235,
-0.015864503,
0.018234137,
0.024593325,
-0.00039954114,
-0.020068262,
-0.014552501,
-0.008601639,
0.0052747796,
-0.0024499611,
-0.035852436,
-0.035691783,
0.01832785,
0.029185329,
-0.010034131,
0.020563608,
-0.0015295523,
0.005248004,
-0.003355309,
0.008220088,
-0.017952994,
-0.019398872,
-0.0117678465,
0.012852255,
-0.0028599615,
-0.02127316,
0.042198237,
-0.01701585,
0.01018809,
-0.02846239,
0.010911029,
-0.010991355,
0.00033092883,
-0.008789068,
0.0030942473,
-0.018729484,
-0.011660744,
-0.015275441,
-0.00043844932,
-0.0036146967,
-0.004638861,
-0.006867924,
-0.0024432673,
-0.028408838,
-0.038985174,
-0.00013283174,
0.019439036,
-0.03205031,
-0.01611887,
-0.033201657,
0.013668909,
0.029694064,
0.00706874,
-0.0011521846,
0.01030858,
0.028649818,
-0.006268821,
-0.03239839,
-0.01534238,
-0.02565096,
0.002722737,
0.021567691,
0.02534304,
-0.016038543,
-0.005840413,
-0.018408177,
0.005321637,
-0.0039661257,
-0.029908268,
-0.0164134,
-0.0069817198,
0.014485562,
0.026159694,
-0.016600829,
-0.0033084515,
-0.01150009,
-0.005485637,
-0.011694213,
-0.017658463,
-0.04195726,
-0.009960498,
-0.008728824,
-0.007236087,
-0.0066637606,
-0.0071557607,
0.008347272,
0.0034373088,
-0.0043142075,
-0.00014653328,
0.008347272,
0.005204494,
0.0339246,
0.020416344,
0.025517082,
-0.0038456358,
-0.023696346,
-0.015489645,
-0.015837727,
0.021058956,
-0.01437846,
-0.02306712,
0.026882634,
-0.00023888795,
-0.012069071,
-0.0045986976,
-0.017136341,
-0.02827496,
0.017886056,
0.007035271,
-0.014552501,
-0.008956416,
0.0031862883,
-0.011279193,
-0.01941226,
0.0139634395,
-0.0015496339,
-0.009545477,
-0.00048990856,
0.03810158,
0.004089962,
-0.019505974,
-0.037351865,
-0.009605722,
0.0123636015,
-0.0049902895,
0.007242781,
0.0052212286,
0.017658463,
-0.0059240866,
0.00025938795,
-0.023776673,
-0.028783696,
-0.018595606,
0.009532089,
0.038396113,
0.022893079,
0.017484423,
0.0071022096,
0.020456506,
0.029586961,
0.017752178,
0.00718923,
-0.009036742,
-0.018595606,
-0.038315784,
0.01875626,
-0.013548419,
-0.016266135,
0.016466951,
-0.0037887378,
0.0104491515,
0.00022319915,
-0.024379121,
0.00017540065,
0.00054011267,
-0.03116672,
-0.035745334,
0.029453084,
-0.005422045,
-0.018783035,
-0.037967704,
-0.02096524,
-0.012745153,
0.0045049833,
0.014097317,
-0.016212584,
0.04332281,
-0.03194321,
0.04385832,
0.0021704915,
0.02480753,
0.0031896352,
-0.018823199,
-0.0034908599,
0.0062186173,
0.01255103,
-0.0025219205,
0.004973555,
-0.02354908,
0.005488984,
-0.0012040621,
0.016681157,
-0.013026296,
-0.010147926,
-0.0051241675,
-0.024298795,
0.0020248995,
-0.022759201,
-0.024887856,
-0.048463713,
0.017243443,
-0.010797233,
-0.022585161,
0.013816174,
0.0030591046,
-0.028890798,
0.036468275,
0.011091764,
0.044902567,
-0.006004413,
0.03288035,
0.023227774,
-0.0019713484,
-0.04085946,
-0.00025666857,
0.0076979655,
0.016881973,
0.018421566,
-0.002548696,
-0.014338297,
-0.034968846,
-0.009886865,
0.018060096,
-0.007912169,
-0.035986315,
0.0076845777,
-0.00007399878,
-0.0018893485,
-0.0058638416,
-0.0057969023,
-0.0157574,
0.010763763,
0.01953275,
0.0028917573,
0.0051241675,
-0.0064328215,
-0.008608334,
0.02198271,
0.013976827,
0.055800207,
-0.0052513513,
-0.0035745334,
0.009491926,
-0.043537013,
0.004351024,
0.0060813925,
-0.0010367151,
0.023495529,
-0.0027679205,
0.003114329,
-0.020724261,
0.026896022,
0.022129977,
-0.01141307,
-0.0031344106,
0.03625407,
0.0012818786,
-0.017363932,
0.018595606,
-0.0019596342,
0.0032097169,
0.00043635748,
0.0020717566,
0.002115267,
-0.022544997,
-0.0025637571,
0.028435614,
0.007088822,
0.0011998785,
-0.0016232666,
-0.017993158,
0.006975026,
-0.033308763,
-0.026199857,
0.005211188,
-0.03253227,
-0.0010065926,
-0.007818455,
0.0011638989,
0.008561476,
-0.0033937986,
0.009592334,
-0.005987678,
0.027953655,
-0.009177313,
-0.005529147,
0.01360197,
-0.0028716756,
-0.027137002,
0.0035879212,
-0.0017655116,
-0.01180801,
0.02456655,
-0.011486703,
-0.0013212052,
0.006392658,
0.020282466,
0.011392988,
0.021942548,
-0.017872667,
-0.004782779,
0.0066537196,
0.004521718,
0.015235278,
-0.004150207,
-0.009431681,
-0.0339246,
0.012992826,
0.0068511893,
-0.024138141,
-0.006975026,
0.0051241675,
-0.028837247,
-0.0017621646,
-0.010000661,
-0.02168818,
-0.021634629,
-0.019131117,
-0.012062377,
-0.0061416375,
0.011761152,
-0.016346462,
-0.023870386,
0.022022875,
0.0008543068,
-0.015971605,
-0.031059617,
-0.014204419,
0.017658463,
0.0021035527,
-0.015181727,
-0.011399683,
0.002655798,
-0.014833644,
-0.009096987,
0.006673801,
-0.015021074,
0.04819596,
0.015837727,
-0.020510057,
-0.02001471,
0.0006254597,
-0.04187693,
-0.013414541,
0.0031444514,
-0.0051308614,
0.0017454299,
0.025677735,
-0.009532089,
-0.00706874,
-0.0094986195,
0.013869725,
-0.021915773,
-0.022076426,
0.021460589,
-0.0024683692,
-0.009076905,
0.020590384,
-0.031675454,
-0.017845891,
0.028328512,
0.0067909444,
-0.0060445764,
0.02151414,
0.0061951885,
0.00641274,
-0.007604251,
0.004364412,
0.021139283,
0.014217807,
0.026199857,
-0.012149397,
0.0010333682,
-0.007363271,
-0.0010986335,
-0.025396591,
-0.0017337156,
-0.004729228,
-0.0023261243,
0.0037452276,
0.004401228,
-0.031702228,
0.003999595,
-0.008635109,
0.010683437,
-0.00043259218,
-0.0073766587,
0.0026156348,
0.013548419,
-0.007945639,
-0.017069401,
-0.0057600862,
-0.024272019,
0.0010417355,
0.00039452073,
-0.0029520025,
-0.0014316542,
-0.0022725733,
0.008876089,
-0.012932582,
0.0006873781,
0.004197065,
0.013950052,
-0.013561807,
0.020081649,
0.01030858,
-0.017752178,
-0.016614217,
-0.00035038294,
0.002125308,
-0.030898964,
-0.0022073078,
-0.018916912,
-0.01935871,
-0.0027244103,
0.0034440027,
-0.0026106143,
-0.006800985,
-0.0062119234,
-0.00074887817,
-0.014606052,
-0.0038724113,
0.18732162,
0.0009722865,
0.029586961,
0.006804332,
-0.014191031,
-0.0025821654,
0.007470373,
-0.0066704545,
0.01303299,
0.0031310637,
0.013227113,
0.009438375,
-0.0017922871,
-0.0002964135,
0.005248004,
-0.0037017171,
-0.028007206,
-0.010676743,
-0.030872189,
0.0024399203,
0.007483761,
-0.016252747,
0.022397732,
-0.0032883699,
0.020898303,
-0.000055852084,
-0.017671851,
-0.008461068,
0.0025269408,
0.0377535,
-0.0145257255,
0.0043711057,
-0.00029202065,
0.006519842,
0.021822058,
0.012263194,
0.0064863726,
-0.006285556,
0.00991364,
0.015891278,
0.009163925,
-0.007925557,
0.0044748606,
-0.005954209,
-0.023816835,
-0.0044748606,
-0.002140369,
-0.021607853,
-0.006811026,
0.015984992,
-0.043938648,
0.0029653902,
0.011319356,
-0.0076444144,
0.013990215,
-0.0061282497,
0.0022407772,
0.0069817198,
-0.0043711057,
0.03180933,
-0.004980249,
0.0110114375,
-0.024539774,
-0.0018023279,
-0.01018809,
0.03357652,
-0.020884914,
-0.0036749416,
0.009204089,
-0.019934382,
0.00031147472,
0.014994298,
-0.0043543708,
-0.009846701,
-0.010208172,
-0.004156901,
0.039386805,
0.020108424,
0.033148106,
0.0068277605,
-0.024272019,
0.01677487,
-0.043296035,
-0.0010902662,
-0.012745153,
-0.019505974,
0.016159033,
0.011419764,
-0.010295192,
-0.009304497,
0.021313323,
0.0008668578,
0.001855879,
0.0032833496,
-0.0058772294,
-0.011674132,
0.0068880054,
0.0021487365,
0.008434293,
-0.01486042,
0.0065968214,
0.062279887,
-0.0013814501,
-0.003591268,
-0.028489165,
0.0039259624,
-0.012330133,
0.0041435133,
-0.019559525,
-0.025276102,
-0.022692263,
-0.027070062,
0.012330133,
-0.0068444954,
-0.009244252,
0.012711683,
0.029265655,
-0.010977968,
0.030765086,
-0.0024583284,
-0.0008919599,
-0.02408459,
0.010596417,
0.031836107,
-0.00543878,
0.009023354,
-0.029506635,
0.023522304,
-0.0022123284,
-0.028087532,
0.00019610985,
-0.006342454,
0.0035577987,
-0.005719923,
-0.03242517,
-0.0026809,
-0.0014659604,
0.009599028,
-0.026079368,
0.0007392557,
-0.013173562,
-0.0031611861,
0.0030808595,
0.0067306994,
-0.008735517,
-0.0037552684,
0.017725402,
0.029158553,
-0.0071022096,
0.0039560846,
0.017283605,
-0.020095037,
0.0092710275,
-0.00917062,
0.016520502,
-0.024258632,
-0.015730625,
-0.050230898,
0.01815381,
0.023134058,
-0.030095698,
0.008220088,
0.009009967,
-0.019077566,
-0.0052245758,
0.005211188,
-0.16922136,
0.020242302,
-0.0012383683,
-0.02923888,
0.016922137,
-0.0011371233,
0.017203279,
0.001473491,
0.005378535,
0.0053584534,
0.024887856,
-0.0027311041,
-0.032746475,
-0.045330975,
-0.0026173082,
0.025369816,
-0.025302878,
0.030229576,
0.01648034,
-0.0012894092,
-0.0038523297,
-0.038797744,
-0.0040832683,
-0.012323438,
0.00093714363,
0.028301736,
0.0067675156,
-0.008367354,
-0.0045417994,
-0.0050572287,
-0.0030992678,
0.016185809,
0.049052775,
0.0037485745,
0.026280183,
-0.015302217,
-0.013280664,
-0.008032659,
0.0135952765,
0.0038155133,
0.02020214,
0.017243443,
-0.011433152,
-0.006389311,
-0.0054956777,
0.010924417,
0.014365072,
0.0043275952,
0.02241112,
-0.0017203279,
0.012028907,
-0.03146125,
-0.0054053105,
0.023093896,
0.016011767,
0.015770787,
0.0033653497,
0.012745153,
0.009471844,
-0.012845561,
-0.0066570668,
-0.027926879,
0.042225014,
-0.01569046,
0.021915773,
-0.018193973,
-0.0049166568,
-0.0008308782,
-0.025155611,
0.014298134,
-0.013019602,
-0.009572253,
0.013675603,
-0.024941407,
0.011667438,
0.021714956,
-0.01563691,
0.006268821,
-0.028596267,
0.02391055,
-0.017430872,
0.011647357,
-0.010020743,
-0.03464754,
-0.022022875,
-0.010094375,
0.012832173,
0.014766705,
-0.0004593677,
-0.0022775936,
0.022893079,
-0.02073765,
0.0013630419,
-0.00718923,
0.026266797,
0.02486108,
-0.020925079,
-0.007082128,
0.0059977192,
0.0034440027,
0.017363932,
-0.0020165322,
-0.02570451,
0.008046047,
0.018287688,
0.007938945,
0.0088493135,
0.00029704106,
0.051810652,
0.008728824,
-0.017725402,
-0.012510867,
0.0060412292,
0.04873147,
-0.0037920848,
0.026494388,
-0.0006844495,
0.008735517,
0.02020214,
-0.027230715,
0.049534734,
0.0029235533,
-0.004521718,
0.019813893,
-0.0052145347,
-0.019398872,
-0.12745152,
-0.014070542,
0.0043275952,
0.02241112,
-0.006975026,
0.0058002495,
0.021862222,
0.0056898003,
-0.017524585,
0.025476918,
-0.031568352,
-0.021340098,
0.016547278,
-0.007604251,
0.0024650223,
0.015891278,
-0.0031210228,
-0.010094375,
-0.015864503,
0.010342049,
-0.0044213096,
-0.0067909444,
-0.023441978,
0.010234947,
0.015288829,
-0.008822538,
-0.028596267,
0.03518305,
0.00008351665,
0.015275441,
0.0028348593,
-0.0115737235,
0.023428591,
-0.0018374708,
-0.031782556,
-0.019880831,
0.004802861,
-0.019626465,
0.024700427,
0.008702048,
0.008293721,
0.008179924,
0.017471034,
0.012758541,
-0.004046452,
0.012370296,
0.00074553123,
0.018890137,
0.0020817977,
-0.0034406558,
-0.028944349,
-0.024379121,
-0.0328268,
-0.022116588,
0.03116672,
-0.025999041,
-0.0017889402,
0.035959538,
0.00025374,
-0.004682371,
-0.01222303,
-0.0054186983,
0.007477067,
-0.000045183708,
0.030818637,
-0.008320496,
-0.016761484,
-0.039279703,
0.044688363,
-0.022317406,
0.001327899,
0.017765565,
-0.013869725,
-0.002978778,
-0.023200998,
-0.004230534,
-0.016212584,
-0.006503107,
0.010248335,
-0.011794622,
-0.014686379,
-0.026882634,
0.03547758,
-0.021607853,
0.020697486,
0.010977968,
0.025142225,
0.008501232,
0.02504851,
-0.027190553,
0.00086016394,
0.020402955,
0.019706791,
-0.009009967,
-0.008440986,
0.02415153,
-0.00730972,
-0.026494388,
0.008159843,
0.013334215,
-0.034486886,
-0.0014785114,
-0.06083401,
0.013541725,
0.008996579,
0.00020991599,
0.018301075,
-0.007938945,
-0.0035678395,
0.0024499611,
-0.0052145347,
0.01917128,
-0.028167859,
-0.014485562,
0.002791349,
0.00038719928,
-0.010589723,
-0.03242517,
0.05960233,
0.0032113902,
0.0074569853,
0.025972266,
-0.011078376,
0.00022842875,
0.004679024,
0.012410459,
-0.00025143896,
0.0048195957,
-0.021085732,
0.017578136,
-0.00543878,
-0.0068746177,
0.0052881674,
-0.03068476,
0.0037954317,
-0.007490455,
-0.0064160866,
-0.02678892,
-0.023281325,
0.033603292,
0.030256351,
0.031434473,
-0.024459448,
-0.021741731,
0.016855197,
0.022143364,
-0.008829231,
-0.0026189818,
-0.021942548,
0.0045986976,
0.004960167,
-0.030095698,
0.034834966,
0.011265805,
-0.016694544,
-0.0018441647,
-0.014284746,
-0.0006438679,
0.006968332,
-0.003999595,
-0.018180586,
-0.029265655,
0.03756607,
0.007778292,
0.03044378,
-0.0038054725,
-0.0026976347,
-0.0043175546,
-0.043697666,
-0.000033757042,
-0.00555927,
-0.04230534,
-0.03716444,
0.008320496,
0.0023512263,
0.018903526,
0.026293572,
0.002520247,
-0.0029302472,
-0.022518221,
0.0003664901,
0.021299936,
0.034058478,
0.015596747,
-0.032639373,
0.014485562,
0.023227774,
-0.015610135,
0.01587789,
0.03869064,
-0.007624333,
-0.0071557607,
0.0004593677,
0.02487447,
0.00905013,
-0.012162785,
0.036575377,
0.02366957,
-0.00681772,
0.013883113,
0.020697486,
0.01099805,
-0.0068880054,
-0.006496413,
0.006914781,
-0.021299936,
0.0018575524,
0.032023534,
-0.025450142,
-0.052881673,
-0.01587789,
-0.022250466,
0.0004815412,
0.016868586,
0.0012785316,
0.005207841,
0.0020583689,
0.0011220621,
0.029319206,
0.00034013292,
-0.012718378,
-0.002993839,
0.00531829,
0.027297655,
-0.029078227,
-0.020871527,
0.039413583,
-0.01617242,
0.021714956,
-0.022598548,
0.020684099,
-0.029560186,
-0.0019680015,
-0.009304497,
0.000310638,
-0.026561327,
0.009317885,
-0.0018793077,
0.008293721,
-0.00024579102,
-0.006064658,
0.08059435,
0.00042924524,
0.0015362462,
0.009264334,
-0.027016511,
0.012035602,
-0.011058294,
0.010000661,
-0.02044312,
-0.03354974,
0.02972084,
-0.010355437,
0.02306712,
-0.017337156,
-0.007135679,
0.0027880021,
0.0006777556,
0.022183528,
-0.024298795,
-0.016748095,
0.010154621,
-0.01732377,
0.0022140017,
0.009364742,
-0.0051609837,
0.0019211444,
0.01863577,
-0.013166867,
0.012577806,
-0.047017835,
0.022812752,
-0.013427929,
-0.042251788,
-0.014070542,
-0.01204899,
-0.00905013,
0.0060981275,
-0.020992016,
0.01599838,
0.027471695,
0.011834785,
-0.0077448227,
-0.024057815,
-0.03277325,
-0.0057600862,
0.01022156,
-0.0068813115,
-0.0029771044,
-0.01546287
] |
Pattern recognition by the innate immune system enables the detection of microorganisms, but how the level of microbial threat is evaluated — a process that is crucial for eliciting measured antimicrobial responses with minimal inflammatory tissue damage — is less well understood. New evidence has shown that features of microbial viability can be detected by the immune system and thereby induce robust responses that are not warranted for dead microorganisms. Here, we propose five immune checkpoints that, as defined here, collectively determine the gravity of microbial encounters. | [
-0.011831812,
-0.01183844,
-0.0070062885,
-0.0036357136,
-0.020694071,
0.020031225,
-0.006605266,
-0.024392756,
-0.022748895,
-0.005147004,
0.023584083,
-0.0073310835,
-0.008179527,
-0.018268052,
-0.012567571,
0.0060948743,
0.05141038,
0.0149670765,
-0.010559146,
0.0044874717,
-0.037490603,
0.012070437,
-0.011400961,
-0.007622736,
0.0038942238,
0.021555772,
0.013933036,
-0.053001214,
-0.010492861,
-0.007901131,
0.0060683605,
-0.017751032,
-0.031445444,
0.011884839,
-0.013296703,
-0.009604647,
0.031100763,
-0.0154840965,
0.014980333,
0.013528699,
0.0071918857,
0.020044481,
0.011500388,
-0.018387364,
-0.0015427754,
0.0044576433,
0.0058065364,
-0.004013536,
-0.013628126,
0.012355461,
0.026261982,
-0.026500607,
-0.021966737,
0.007211771,
-0.015444326,
-0.009505221,
0.0022387644,
0.011613073,
-0.0039737653,
-0.03300976,
-0.031604525,
-0.0080734715,
-0.01564318,
0.017698005,
0.005789965,
-0.0029480103,
0.0045007286,
0.021118293,
0.0008989857,
0.01684956,
0.026606662,
0.03369912,
0.0038378818,
0.022046277,
0.03828602,
-0.024644636,
-0.015948089,
0.0018161996,
-0.013694411,
0.0116661005,
0.00916054,
-0.012494658,
-0.0045139855,
0.020945953,
0.0045703272,
-0.007549823,
0.013528699,
-0.002402819,
0.027813043,
-0.012256034,
-0.0020829954,
0.016690478,
0.024657894,
0.035051327,
-0.027110426,
0.034759674,
0.0017880287,
0.02285495,
0.016756762,
-0.013601612,
-0.027547905,
0.011792041,
-0.007980673,
-0.018201768,
-0.018811587,
0.00052903447,
0.005730309,
-0.014914049,
0.023902249,
0.008411523,
-0.027813043,
0.01633254,
-0.018771816,
-0.037649687,
0.0054717986,
0.033168845,
0.018864615,
0.0023713338,
-0.0188381,
0.0034965158,
0.027733501,
0.023093576,
0.018387364,
-0.037835285,
0.02929782,
0.017074928,
-0.008703176,
-0.0062639005,
-0.015351527,
-0.007874617,
-0.0007200171,
0.016663963,
0.021224348,
-0.0027806414,
-0.017618462,
0.01680979,
-0.021423202,
0.0008940144,
-0.0020133965,
0.0008824145,
0.020389162,
0.029615985,
-0.025559366,
-0.006485954,
0.015059874,
0.0051967176,
0.028104696,
0.021529257,
-0.011884839,
0.013071335,
-0.020283107,
-0.028794056,
-0.021542514,
-0.0038710241,
-0.0014590911,
0.023398485,
0.007781819,
0.023478027,
-0.012733283,
-0.019752828,
-0.0019123125,
-0.023584083,
0.0042952457,
0.0010199551,
0.0014044063,
0.02424693,
0.0130249355,
0.030543972,
0.0069201184,
0.008762832,
-0.007921017,
0.012408488,
-0.0045272424,
0.018917643,
-0.007065945,
-0.0046167267,
0.01240186,
0.022377701,
-0.01629277,
-0.031843152,
-0.013893264,
0.011951124,
0.021118293,
-0.009153912,
-0.028502403,
-0.00959139,
0.022152333,
0.009213568,
0.009690817,
-0.014569368,
0.0071256007,
0.010645316,
-0.0010149839,
0.011334677,
-0.6431203,
-0.021356918,
0.025440052,
-0.0009901271,
0.008027072,
0.01818851,
0.011135823,
-0.020588016,
0.0016330883,
0.032346915,
-0.010976739,
-0.005190089,
-0.014635653,
-0.031604525,
-0.010313893,
-0.01663745,
-0.01123525,
-0.02985461,
0.0141584035,
0.0013555213,
-0.023014033,
0.0027822985,
-0.007178629,
0.006485954,
-0.046611372,
0.0011864954,
0.017896859,
-0.0032032062,
-0.0056408243,
0.023146603,
-0.029218279,
0.012786311,
-0.00029931666,
0.012799568,
0.047990095,
0.004182562,
-0.010784514,
0.017353324,
0.006784235,
0.02497606,
-0.011434104,
-0.0071256007,
0.019328607,
0.008583863,
-0.0042952457,
0.04199796,
0.0081066135,
0.009697446,
-0.012017408,
-0.010850799,
0.012594085,
0.02497606,
-0.0026165869,
0.0053425436,
0.02243073,
0.0028833826,
0.026049871,
-0.017141214,
0.00566071,
0.002646415,
-0.0031385787,
-0.011129194,
0.015789006,
-0.04173282,
-0.045683388,
0.042024475,
-0.025426796,
-0.0022934491,
0.0048619797,
-0.0089418,
0.015590152,
0.022152333,
-0.007152115,
-0.013614869,
0.0058164787,
0.030570485,
0.0045338706,
-0.0024989317,
0.018983927,
0.030040208,
-0.011089424,
-0.01037355,
-0.02700437,
-0.0034037172,
0.020124022,
-0.009352765,
0.0006479325,
0.0076293643,
-0.013707668,
-0.007556451,
0.008504322,
0.0075166803,
-0.01845365,
-0.044834945,
-0.017857088,
0.00864352,
-0.03836556,
-0.010062011,
0.013336473,
-0.010777886,
-0.026699461,
-0.018877871,
0.0023000776,
0.0051105474,
0.036085367,
0.0012270948,
-0.022921236,
-0.0027441848,
0.049421843,
-0.017870344,
0.01629277,
0.014503083,
-0.008245812,
-0.0028800685,
0.012633856,
-0.020269848,
0.02306706,
0.022881465,
-0.010055383,
-0.013104477,
0.023106832,
0.0038146821,
0.009704074,
-0.004378102,
0.016186714,
0.0014773194,
-0.0058297357,
-0.011255135,
0.010101782,
-0.018215025,
-0.0039505656,
0.0023000776,
0.003642342,
0.0033059474,
0.016491624,
0.0140921185,
0.014224688,
-0.012176492,
-0.014556112,
-0.023610596,
-0.019474434,
-0.026845288,
-0.008928544,
-0.009743845,
-0.022934493,
-0.003073951,
-0.013919778,
0.008789346,
0.012203006,
0.0053458577,
0.002303392,
-0.0009975841,
0.0029165251,
0.0017896858,
0.007523309,
-0.004268732,
-0.001933855,
-0.021873938,
0.0019587118,
0.006002076,
-0.02402156,
0.018877871,
0.001579232,
0.0033341183,
-0.011917982,
-0.010559146,
-0.0016761733,
-0.005093976,
0.0031104076,
-0.040301073,
-0.0018311137,
-0.017074928,
-0.018983927,
0.023782937,
0.015059874,
0.017008644,
-0.021356918,
-0.007841475,
-0.0027839558,
-0.00674115,
0.003798111,
-0.03457408,
0.010095154,
-0.008292211,
0.019209294,
0.010618802,
0.02627524,
-0.020574758,
0.026063127,
0.044622835,
0.025479823,
0.011195479,
-0.017485892,
0.035926286,
-0.0064130407,
-0.016770018,
-0.010419949,
-0.0024823605,
-0.008477808,
0.022589812,
0.009438936,
-0.024644636,
0.00295961,
-0.024591608,
-0.013614869,
-0.010393435,
-0.00009005392,
-0.021184577,
0.01365464,
0.008888773,
-0.007761934,
0.005717052,
0.008325353,
-0.021595541,
0.019911911,
0.01633254,
-0.0016297741,
-0.007311198,
-0.013462414,
-0.019766085,
0.008623634,
-0.0045868983,
0.0357672,
-0.018095711,
-0.01154016,
0.015537124,
-0.004878551,
0.0051702033,
-0.016624192,
-0.028714515,
0.002404476,
-0.00782159,
0.030517457,
0.013309959,
0.015099646,
0.0070460592,
-0.0012826081,
0.0018957413,
0.025082115,
0.012070437,
-0.008484436,
0.0017283725,
-0.0053856284,
-0.0016562879,
0.013720925,
0.00037761542,
0.022059536,
0.024313213,
-0.007669135,
0.008278954,
0.0011135823,
-0.027388822,
-0.026898315,
-0.008716432,
-0.0068803476,
-0.019235808,
0.0058131646,
-0.0032744622,
0.021078521,
0.02532074,
0.025864275,
0.0016944016,
-0.009312995,
-0.016823046,
0.026898315,
0.0045139855,
-0.000797073,
-0.0056143105,
-0.010704973,
0.00091638544,
-0.021211091,
-0.004106335,
0.008557349,
-0.01201078,
0.0012146664,
0.02095921,
0.038392074,
0.012673627,
0.001558518,
0.0074835382,
-0.001592489,
-0.015417811,
0.018917643,
0.034149855,
-0.0071322294,
-0.013986063,
-0.036827758,
-0.013031564,
-0.0067776064,
-0.0020415676,
0.0059225345,
0.012541058,
-0.010970111,
-0.00011454818,
-0.011639587,
0.0012718369,
0.03409683,
-0.03465362,
0.0058562495,
0.010618802,
-0.000789616,
-0.0024790464,
-0.011911353,
-0.025227942,
0.014569368,
-0.003113722,
-0.0075166803,
-0.02168834,
-0.021423202,
-0.012653742,
0.003060694,
0.01067183,
0.00009740738,
-0.016465109,
0.021873938,
0.024419269,
-0.008776089,
0.017737774,
0.0323204,
-0.0044178725,
-0.0003262448,
-0.027335795,
0.02453858,
-0.01084417,
0.031233331,
-0.0037285122,
0.013488928,
0.039770797,
0.0011972666,
-0.0016538022,
-0.00941905,
-0.03300976,
0.020601273,
-0.025121886,
-0.014290973,
-0.009014714,
0.026739232,
-0.002648072,
0.011129194,
0.011288278,
0.020667557,
-0.006356699,
-0.020110765,
0.004265418,
0.013343102,
-0.0039505656,
0.033460498,
0.024406012,
0.008146385,
-0.012222892,
0.021860681,
0.010797771,
-0.01041332,
-0.024525324,
-0.006966518,
0.025002575,
-0.00068190345,
0.013237047,
-0.015735978,
-0.016465109,
0.010002355,
0.01464891,
0.012879109,
0.00021749653,
0.012435002,
0.01918278,
0.004818895,
0.0037815399,
0.0030789224,
0.010698345,
0.011089424,
0.01612043,
0.00083021534,
-0.005564597,
0.021622056,
-0.0008824145,
-0.023650367,
-0.037994366,
-0.007284684,
0.008418152,
0.00030221662,
0.0015187473,
0.0022122506,
-0.027203225,
-0.0021310518,
-0.03369912,
0.01058566,
0.004225647,
-0.021012237,
0.0006611895,
-0.013442529,
-0.008411523,
-0.03539601,
0.0102409795,
-0.009014714,
-0.026633177,
-0.020481959,
0.003983708,
0.008563978,
0.0059623052,
0.008272326,
-0.02264284,
0.01067183,
0.010168067,
-0.0073178266,
-0.0037384548,
0.012753168,
-0.029695528,
0.03582023,
0.009604647,
0.0119577525,
-0.023133347,
-0.017061671,
-0.0003989508,
0.00062804716,
0.018082455,
0.009571505,
0.030199291,
-0.00223545,
0.0161602,
-0.010055383,
0.03102122,
-0.027415335,
-0.039876852,
0.0023879048,
-0.042050987,
-0.006814063,
-0.020601273,
-0.02510863,
-0.038816296,
-0.01240186,
0.00847118,
-0.0034103456,
-0.012792939,
0.02985461,
-0.0074437675,
0.030411402,
0.020070994,
0.008676662,
0.016557908,
0.0069864034,
0.02073384,
0.016823046,
-0.015046618,
-0.021356918,
-0.001414349,
0.022178847,
0.030517457,
-0.00260333,
0.008272326,
-0.012176492,
0.014768222,
-0.035210412,
-0.020760356,
-0.02095921,
0.0065489244,
0.015881805,
-0.042501725,
-0.004961407,
-0.014582626,
-0.0013107791,
0.013641383,
-0.018055942,
-0.023729907,
-0.006476011,
-0.018347593,
-0.010923712,
-0.0044742147,
0.038445104,
-0.032559026,
-0.0013439215,
0.016186714,
-0.03979731,
0.022523528,
-0.011937867,
0.014914049,
-0.024193902,
0.007622736,
-0.0268718,
-0.043906957,
-0.0024823605,
0.0017714575,
0.059125915,
0.01983237,
0.013084592,
-0.009458821,
0.031869665,
0.02243073,
-0.00046357833,
-0.0054883696,
-0.0030988078,
0.010996625,
0.013986063,
-0.0015974604,
0.0070460592,
-0.007841475,
-0.021807654,
-0.013276817,
0.020839898,
-0.00095781335,
-0.0042720465,
-0.011613073,
-0.022523528,
-0.018042684,
-0.01313762,
0.008159641,
-0.0034932017,
0.017406352,
-0.035236925,
-0.006386527,
0.023345457,
-0.00036622275,
0.016173458,
0.0024293328,
0.029271306,
-0.013495557,
0.02315986,
-0.023053804,
0.012952022,
-0.0045206137,
-0.0028137837,
-0.004944836,
-0.009876414,
0.02017705,
0.02308032,
-0.0025851016,
0.004437758,
-0.008868887,
-0.017605206,
-0.0055546546,
-0.017896859,
-0.023332201,
-0.010280751,
-0.018917643,
-0.013813723,
0.017578691,
-0.018268052,
-0.00682732,
-0.010393435,
-0.00197694,
-0.014609139,
0.014251201,
-0.044622835,
-0.012779683,
0.036880784,
0.015020104,
0.0122494055,
-0.02860846,
0.02860846,
0.0022089363,
0.0027474992,
-0.0078812465,
-0.011221993,
-0.014436799,
0.00083062967,
0.020455446,
0.004938207,
0.0013894922,
-0.034892246,
0.026765745,
0.004977978,
-0.009326251,
-0.044622835,
0.02583776,
0.010724858,
0.0053127157,
-0.017446123,
-0.026500607,
-0.020362647,
0.032877192,
-0.018268052,
0.0011541817,
-0.0062771575,
-0.010406692,
-0.007980673,
0.0027822985,
-0.0058197933,
0.010207837,
0.0005103919,
-0.01084417,
0.0059391055,
-0.017393095,
0.01897067,
0.009796873,
0.016465109,
0.014198174,
0.011188851,
0.026341524,
0.016491624,
-0.0047758096,
0.0046598115,
0.015961345,
-0.0025983588,
0.036695186,
-0.0041759335,
-0.016610935,
0.0016811447,
0.0030640084,
0.0038511388,
-0.03343398,
0.00055596256,
-0.004726096,
-0.010360292,
0.000052794698,
0.016955616,
0.011009882,
-0.015271986,
-0.005650767,
-0.030172776,
-0.0031965778,
-0.02423367,
-0.010287379,
-0.0044907858,
-0.021184577,
-0.012600713,
0.01956723,
-0.003987022,
0.015828777,
0.005090662,
-0.0049978634,
-0.018440392,
0.017751032,
-0.03210829,
0.03409683,
0.0058264215,
-0.0034070315,
-0.020044481,
-0.013681154,
-0.015828777,
-0.030199291,
0.0188381,
-0.010559146,
-0.036880784,
-0.00050376344,
0.0061943014,
0.011566673,
-0.0046995822,
-0.014330744,
-0.0065257247,
0.013203904,
0.023955276,
-0.00708583,
-0.005279573,
0.029828098,
-0.016730249,
-0.007768562,
0.0386307,
-0.039505657,
0.0154840965,
0.013230418,
0.0030176092,
0.00503432,
-0.01918278,
-0.036244452,
-0.01430423,
0.020906182,
-0.01749915,
-0.025612393,
0.011301534,
-0.0050873477,
-0.01962026,
0.0005369057,
0.005448599,
-0.016054144,
-0.0022089363,
-0.0029612673,
0.011129194,
-0.0028999539,
-0.007927645,
-0.005080719,
0.01240186,
-0.01127502,
-0.0025387025,
0.001202238,
-0.039479144,
0.047937065,
0.008583863,
0.019434663,
-0.021940222,
0.010419949,
-0.024604866,
-0.023968533,
0.007284684,
0.012521172,
0.00018176496,
0.018135482,
0.003231377,
0.009266595,
-0.011487132,
0.018069198,
-0.006356699,
-0.020985723,
-0.0066317804,
-0.011361191,
0.027070655,
0.009644418,
-0.01931535,
-0.010081897,
0.036111884,
0.0007303741,
-0.004225647,
0.016862817,
-0.011831812,
0.007695649,
0.0039406233,
0.011739014,
0.011586559,
0.028873598,
0.025572622,
0.001778086,
-0.011334677,
0.00069764606,
-0.012905623,
-0.0005215774,
0.010731487,
0.0097239595,
0.028369835,
0.021211091,
-0.021887194,
-0.034759674,
0.018519934,
-0.027786529,
0.020906182,
0.015735978,
-0.0140921185,
0.0014831192,
-0.0068604625,
-0.018586218,
-0.02298752,
-0.012567571,
-0.01948769,
0.021648569,
0.001819514,
-0.012905623,
-0.017870344,
0.006340128,
0.014609139,
-0.02052173,
0.015444326,
-0.016040888,
0.0032247487,
-0.00040847922,
0.0072515416,
0.0207471,
0.025638906,
0.0035462293,
0.011434104,
0.004136163,
-0.03266508,
-0.0050409483,
-0.013747439,
0.0036688559,
0.025068859,
0.012256034,
0.002048196,
0.0020266534,
-0.0068869763,
-0.008126499,
-0.021701599,
0.02528097,
0.19196038,
-0.019713057,
0.0024459038,
0.017525664,
0.000010344032,
-0.0015162616,
0.003456745,
-0.009001457,
-0.0042886175,
-0.013064707,
0.03285068,
0.011818555,
-0.010075268,
0.004152734,
0.011845069,
-0.021622056,
-0.0043018744,
-0.006959889,
-0.011884839,
-0.011785412,
0.0042322758,
-0.024883261,
0.009478706,
0.009770359,
0.040592726,
0.0053591146,
0.011944496,
0.027680473,
0.0073575974,
-0.011347934,
-0.006363327,
-0.0041991333,
0.012541058,
0.004338331,
-0.0006682322,
-0.00021521801,
-0.0134359,
0.008451294,
0.024604866,
-0.013959549,
0.0083319815,
-0.0038345675,
-0.0065389816,
-0.013237047,
0.014184917,
0.003342404,
-0.023398485,
-0.017379837,
0.0036787987,
-0.010479605,
-0.0207471,
-0.008040329,
-0.017830573,
-0.0019089982,
0.010777886,
-0.0024657894,
-0.014370514,
-0.01110268,
0.0052530593,
0.002232136,
-0.01745938,
-0.0025552737,
-0.028104696,
0.02644758,
-0.022841694,
0.056845725,
-0.014423542,
0.010572404,
-0.0023431627,
-0.01840062,
0.001130982,
0.004265418,
-0.013416016,
0.008550721,
-0.017313553,
-0.014476569,
0.024140874,
0.0065787523,
0.024883261,
0.014609139,
0.009770359,
0.00937928,
-0.026765745,
-0.005876135,
-0.019288836,
-0.008245812,
0.0340438,
0.0014831192,
-0.03340747,
0.014834506,
-0.010797771,
-0.01011504,
-0.01011504,
-0.022231875,
0.0053259726,
0.0052364883,
0.013601612,
-0.0006313614,
0.0019139695,
-0.012958651,
-0.03409683,
0.06533016,
0.0022669353,
0.0010439834,
-0.010877313,
0.027070655,
-0.019713057,
0.012945394,
-0.0014856049,
-0.009876414,
0.025360512,
-0.015245472,
0.00924671,
-0.020773612,
-0.009491963,
0.03067654,
-0.011546788,
-0.0068206913,
0.028714515,
-0.0042455327,
0.011778784,
-0.0060683605,
0.0016024316,
0.030490944,
-0.006499211,
-0.005879449,
-0.025506336,
0.017737774,
-0.0006408898,
-0.025851017,
-0.006472697,
0.00162066,
0.0075034234,
0.0050011775,
0.00081654417,
-0.020362647,
0.01417166,
-0.029191764,
-0.043085027,
0.0069930316,
-0.0140921185,
-0.0043847305,
-0.004696268,
0.011758898,
0.0063500702,
0.0035893144,
0.026500607,
0.013561841,
-0.021224348,
-0.009412422,
0.011619701,
-0.02044219,
-0.009286481,
-0.008921916,
0.004252161,
-0.024737434,
-0.01547084,
-0.0011334677,
0.008736318,
-0.008365124,
-0.028581945,
0.008537464,
0.00933288,
-0.011944496,
-0.01870553,
0.015139416,
-0.16534045,
0.009511849,
0.018944155,
-0.026527122,
0.035846744,
0.0050707767,
-0.014861021,
0.012819453,
-0.014251201,
-0.0083319815,
0.03555509,
-0.00046772114,
-0.014450056,
-0.038179964,
-0.0031816636,
-0.002802184,
0.0027972127,
0.028025154,
0.00088738586,
0.00022101791,
0.006698065,
-0.019726316,
0.01642534,
-0.017923372,
0.0056275674,
0.002005111,
-0.007867989,
0.02597033,
-0.004848723,
-0.020945953,
-0.021250863,
-0.017949887,
0.010247609,
0.0044178725,
0.023610596,
-0.005249745,
0.008636891,
-0.0161602,
-0.0073377118,
0.01694236,
0.03629748,
0.015709464,
0.015364784,
0.0053690574,
0.011685985,
0.014807993,
-0.00691349,
0.00087495754,
0.043350168,
-0.028900111,
0.007311198,
-0.0027143569,
-0.030623512,
0.017512407,
0.017273782,
0.013528699,
-0.014344,
0.016345797,
0.024048075,
-0.01179867,
0.012083693,
-0.02168834,
0.023438256,
0.0047294106,
0.0067212647,
-0.0094654495,
0.012912252,
0.034070317,
-0.003186635,
-0.007039431,
-0.021794396,
-0.021953478,
0.011268392,
-0.022603069,
0.024193902,
0.015245472,
-0.00916054,
-0.01568295,
-0.011076166,
0.0011624672,
-0.0043880446,
0.0021641941,
-0.031843152,
-0.0023017349,
-0.011679357,
0.0040533068,
0.019686544,
0.013071335,
-0.015934832,
-0.003755026,
0.007596222,
-0.017777545,
-0.0083319815,
-0.01905021,
0.00117241,
0.031896178,
-0.005508255,
0.01205718,
-0.017074928,
0.0038909095,
-0.0029248106,
-0.0006529039,
-0.009485335,
0.030888652,
-0.032293886,
0.002472418,
-0.00241939,
-0.017790802,
0.03616491,
0.0014474912,
-0.027256252,
0.0009122426,
0.010022241,
0.027203225,
-0.0130249355,
0.038869325,
-0.0064494973,
-0.0098499,
-0.023146603,
-0.043535765,
0.05233837,
-0.0037417691,
-0.011208736,
0.025227942,
-0.013561841,
-0.037092894,
-0.16417384,
0.0025851016,
0.0012163235,
-0.010161438,
-0.0107911425,
0.0060385326,
-0.010983368,
-0.009518477,
-0.01992517,
0.020561501,
-0.0058363643,
-0.01270677,
-0.010943597,
-0.033089302,
-0.010811028,
-0.024445783,
-0.008630263,
-0.010983368,
-0.009259967,
0.027044142,
-0.008199412,
-0.02044219,
0.015218958,
0.009153912,
0.019553974,
-0.0005659053,
-0.008994828,
0.010950225,
-0.016491624,
0.007874617,
0.016491624,
0.0026977856,
0.012547686,
-0.024498811,
-0.008610377,
0.018122226,
-0.015417811,
-0.012110207,
0.012806197,
0.014078862,
-0.0013480643,
0.0070195454,
0.038869325,
0.009697446,
0.019103238,
0.020985723,
-0.02484349,
0.008570607,
0.007722163,
-0.022192104,
-0.01810897,
-0.03224086,
-0.040963918,
-0.007523309,
0.005892706,
-0.019514203,
0.006234072,
0.02730928,
-0.00981013,
0.0029678957,
-0.0049150074,
-0.0018874557,
-0.032983247,
0.018002914,
0.017843831,
-0.030093236,
-0.013853494,
-0.023782937,
0.016597679,
-0.012613971,
0.01680979,
-0.013356359,
0.006118074,
0.0018741988,
-0.013442529,
0.033036273,
-0.002134366,
-0.015126159,
-0.010234351,
-0.000011884632,
-0.003983708,
-0.015073132,
0.009876414,
-0.015046618,
0.030146264,
0.006270529,
-0.0130912205,
0.0019437977,
0.003586,
0.014794736,
-0.013959549,
0.029350847,
0.019527461,
0.016915845,
0.003486573,
0.023332201,
0.011944496,
-0.014688681,
0.015245472,
0.021436458,
-0.00070137455,
0.0011674386,
-0.03266508,
0.023517797,
-0.045736417,
-0.006247329,
0.0044907858,
-0.0092400815,
0.0037019982,
-0.017180983,
0.024909776,
0.044569805,
-0.035793718,
0.0054253996,
0.0002402819,
0.013429272,
-0.029456902,
-0.030597,
0.016929103,
0.032346915,
0.00842478,
0.015033361,
0.001294208,
-0.016133687,
0.0058264215,
0.023318943,
-0.0065224105,
0.018175254,
-0.020839898,
0.014847764,
-0.0046266695,
-0.0022669353,
0.019964939,
-0.02073384,
-0.0037351407,
0.01179867,
-0.012680256,
-0.01956723,
0.002886697,
0.017857088,
0.00015701179,
0.020588016,
-0.014039091,
-0.026460836,
-0.005306087,
-0.019739572,
-0.016226485,
-0.01814874,
-0.03733152,
0.011381076,
-0.0025635592,
-0.024074588,
0.043959986,
0.0049912347,
-0.02398179,
-0.042634293,
-0.01564318,
0.014609139,
0.015311756,
-0.006966518,
0.0017598578,
-0.043747876,
0.016054144,
0.017247269,
0.011208736,
0.010466347,
0.0251484,
-0.0061711017,
-0.016385568,
0.0068074344,
-0.0021525943,
-0.018572962,
-0.027919099,
-0.016902588,
-0.010526004,
-0.0031402358,
0.021065265,
-0.0100487545,
-0.015431069,
0.0026563578,
-0.018612733,
0.031418927,
0.011858325,
0.02264284,
-0.0196998,
-0.00011724099,
0.041600253,
-0.0038213106,
-0.01365464,
0.03945263,
-0.006529039,
-0.015974604,
0.000519506,
-0.0040864493,
0.0040301075,
-0.006101503,
0.012395231,
0.009962585,
-0.0034169743,
0.02367688,
0.017764289,
0.012739912,
0.020190308,
-0.0023995047,
0.004195819,
-0.03046443,
-0.0005940763,
0.012077065,
-0.029907638,
-0.017061671,
-0.01918278,
0.016266255,
0.014039091,
0.028316807,
0.005418771,
-0.00790776,
-0.018082455,
0.020919438,
-0.007099087,
0.015523868,
-0.03711941,
0.038047396,
0.028661488,
0.002261964,
-0.004238904,
-0.019209294,
0.0075166803,
0.000047253714,
0.03751712,
-0.020760356,
0.02497606,
0.01818851,
0.01832108,
-0.016902588,
-0.025042344,
-0.0078481035,
-0.009995727,
-0.018679017,
0.02268261,
0.035024814,
-0.0031485213,
0.06225455,
0.014383771,
-0.015165931,
0.03237343,
-0.021701599,
0.013250303,
0.027600933,
0.0133165885,
-0.007755305,
-0.0049746637,
0.050084688,
0.006088246,
0.023888992,
-0.026832031,
-0.01015481,
0.014715195,
-0.02415413,
0.0047426675,
-0.0047592386,
-0.02199325,
0.01248803,
-0.009843272,
0.02371665,
0.01365464,
-0.024299957,
-0.01581552,
0.019991454,
-0.0058297357,
0.015842034,
-0.031074248,
0.029483417,
0.008027072,
-0.038179964,
-0.016465109,
-0.009346137,
0.0062672147,
-0.00872969,
-0.005561283,
0.00007110066,
0.013919778,
0.014397028,
0.012514544,
-0.035661146,
-0.014847764,
-0.023226146,
-0.0033473754,
-0.031869665,
-0.0058429926,
0.0045703272
] |
Tumor-associated macrophages and high levels of cyclooxygenase-2 (COX-2) are associated with poor prognosis in breast cancer patients, but their potential interdependence has not been evaluated. The objective of this study was to determine whether macrophages regulate COX-2 expression in breast cancer cells. For this purpose, THP-1 cells were cocultured with HCC1954 breast cancer cells. Coculture led to increased COX-2 expression in the HCC1954 cells and elevated prostaglandin E(2) levels in conditioned media. Similar results were observed when THP-1 | [
-0.03229752,
-0.022574378,
0.0020805052,
-0.042437747,
-0.0036950556,
0.0031834827,
0.0033822467,
0.027527187,
-0.012975055,
-0.025037749,
0.015523144,
-0.0060704486,
0.020580223,
-0.00086592685,
-0.015666515,
0.023108762,
0.04272449,
-0.0043141567,
-0.011710785,
-0.02085393,
-0.021127637,
0.03310561,
-0.011665167,
-0.010772358,
0.014675953,
0.006927415,
0.019667862,
-0.03404404,
-0.0063734823,
-0.0314373,
0.015158201,
0.002253202,
-0.011358875,
0.021714155,
0.00395573,
-0.0103357285,
0.033235952,
0.0003003862,
0.02180539,
-0.00001990695,
-0.0013970503,
-0.026458424,
0.0065820217,
0.011834605,
0.005698988,
-0.0058032577,
0.03214112,
-0.007064269,
-0.00089036505,
0.010980898,
0.013607189,
-0.003704831,
-0.002636067,
-0.0049397745,
-0.016852582,
0.018794604,
-0.021049436,
0.027631456,
0.0002523244,
-0.020801796,
-0.006308314,
-0.005161348,
-0.036311906,
0.0080613475,
0.013528987,
0.013268312,
0.008660898,
0.022026964,
0.01582292,
0.0026588761,
0.03474786,
0.023382468,
-0.017960448,
-0.014415279,
0.009293033,
-0.02623685,
-0.036129434,
0.01733483,
0.0049137073,
0.002781067,
0.029299771,
-0.018273257,
-0.0018198312,
0.0068883137,
0.0041968534,
-0.008823819,
-0.009097527,
0.01261011,
0.029977525,
-0.029039098,
0.03526921,
0.008771684,
0.004395617,
0.024490334,
0.008230786,
0.027370783,
-0.01002292,
0.034070108,
-0.005438314,
-0.023890784,
-0.012981571,
-0.0035744938,
-0.02194876,
-0.023682244,
-0.035608087,
0.008628313,
0.014754156,
0.0065298867,
0.021297075,
-0.004056741,
-0.021166738,
0.03696359,
-0.008230786,
-0.039231457,
0.031306963,
-0.0061225835,
-0.004170786,
-0.0013489886,
0.011502245,
-0.0074748304,
0.004353258,
0.020801796,
0.015301571,
0.0065266285,
0.019889435,
0.0048908982,
-0.007390111,
0.008595729,
-0.027057974,
0.01049865,
0.01607056,
0.018234154,
0.033001345,
0.025102917,
-0.011326291,
0.01199101,
-0.036702916,
-0.013489886,
-0.033965837,
-0.028934827,
-0.019785166,
0.04131685,
0.003476741,
0.0076116845,
-0.02131011,
0.005193932,
0.03190651,
0.014845391,
-0.008947639,
0.009964269,
-0.013620223,
-0.035112806,
-0.008491459,
0.003835168,
0.017217526,
-0.00036616568,
0.0099316845,
0.029899321,
-0.0068883137,
-0.01551011,
0.025337525,
-0.0116977515,
0.019928537,
0.014936627,
0.024646739,
0.019328985,
0.01776494,
0.027084041,
-0.005203707,
-0.011489212,
-0.008921572,
0.024555502,
-0.020971233,
0.020384716,
0.013946066,
0.004395617,
-0.019667862,
0.023656176,
-0.0056957295,
-0.055262912,
-0.018090785,
0.013411684,
0.019719997,
-0.008582695,
-0.010642021,
0.00017147469,
0.027057974,
0.004437977,
-0.009293033,
-0.026223816,
0.0071946057,
0.028882693,
-0.0021896625,
-0.021323143,
-0.63270825,
-0.035503816,
0.001619438,
-0.00061054766,
-0.0143631445,
0.034799997,
0.011378425,
-0.025350558,
-0.04634786,
0.021414379,
-0.014923593,
0.026523592,
0.005141797,
-0.01857303,
0.004115393,
-0.02638022,
-0.0030238198,
-0.015236403,
0.0019289885,
-0.0089280885,
-0.024255726,
-0.016474605,
0.015953256,
0.038214825,
-0.010615953,
0.023903817,
0.038866512,
-0.009612358,
0.002727303,
0.044106063,
-0.013411684,
0.027970333,
0.0010744662,
-0.017738873,
0.042828757,
0.0104791,
-0.012773032,
0.0041903364,
0.02528539,
0.024633704,
-0.0037113477,
-0.026510559,
0.0047475277,
-0.010707189,
-0.035112806,
0.03336629,
0.009201797,
-0.007038201,
-0.006278988,
0.0042001116,
-0.02381258,
0.010003369,
-0.018142918,
-0.00291955,
0.011717302,
-0.008002696,
0.028048536,
-0.01547101,
-0.015835952,
0.010159774,
0.008041796,
0.03203685,
-0.0035321345,
-0.020893032,
-0.0025611233,
0.02114067,
-0.008230786,
-0.000015642992,
-0.0061291005,
0.031802244,
0.010205392,
0.018351458,
-0.0065820217,
0.0018116852,
0.02151865,
0.047807634,
0.006829662,
0.0016846065,
-0.003102022,
0.008146066,
0.0010475841,
-0.0065364037,
-0.050075497,
0.011515279,
0.024412131,
-0.015783818,
-0.03172404,
0.026601793,
-0.00793101,
0.0017530335,
0.02387775,
0.009064943,
-0.01909438,
-0.021036401,
-0.0022548311,
0.031072356,
-0.0053535947,
0.0007364044,
0.015992356,
-0.039648533,
-0.020488987,
0.009455954,
0.028856626,
0.01178247,
0.032610334,
-0.0032160669,
-0.02619775,
-0.0010361796,
0.020645391,
-0.020879997,
0.0070251673,
0.019837301,
0.020723592,
-0.037302468,
0.0016088481,
-0.012981571,
0.026275951,
0.0036689884,
-0.013659324,
-0.008556628,
0.032167185,
0.00083741563,
0.016904717,
0.003392022,
0.039935276,
0.013001122,
0.002062584,
-0.025063816,
0.000039024748,
-0.015431908,
0.012505841,
-0.006347415,
0.008765168,
-0.02437303,
0.022066064,
0.00092946616,
0.015575279,
-0.011626066,
0.0053992127,
-0.030968085,
-0.008778201,
-0.011274156,
0.01772584,
-0.004043707,
-0.00014948031,
0.0074292123,
-0.010772358,
-0.00070707855,
0.005607752,
0.005884718,
0.0017856178,
-0.017843144,
0.0111438185,
-0.0060541565,
0.032479994,
0.0053210105,
0.00519719,
0.018820671,
-0.0072923587,
-0.014141571,
-0.010765841,
0.002284157,
0.007631235,
-0.006738426,
-0.009390785,
0.0012764885,
-0.008087414,
0.012473256,
-0.0023069659,
-0.038866512,
-0.019407189,
-0.011984493,
-0.011241571,
0.010264044,
0.0051450557,
-0.013027189,
-0.005154831,
-0.020436851,
0.00026780192,
-0.009964269,
0.022079099,
-0.0038188759,
0.006500561,
0.0076051676,
0.03310561,
0.008484943,
0.024307862,
-0.016448537,
0.02025438,
0.01913348,
-0.028674154,
0.018951008,
0.011150336,
0.022900222,
0.023343368,
-0.039361794,
0.0038677524,
0.016200896,
0.013229212,
0.019915503,
0.015575279,
-0.01199101,
0.020645391,
-0.0073835943,
0.0013489886,
-0.0017090447,
-0.0021668538,
0.0037667411,
0.033705164,
0.002735449,
0.0056435945,
-0.007057752,
-0.0026442131,
-0.003721123,
0.0048322463,
0.0035353927,
0.01737393,
-0.016005391,
0.013476852,
-0.017986514,
-0.0059173023,
0.0060411226,
0.016083593,
-0.0056598866,
-0.008458875,
-0.005200449,
0.023434604,
0.02739685,
-0.008484943,
0.0076898867,
-0.0013587639,
0.0030531457,
0.0045943814,
0.009579774,
0.02880449,
-0.0045748306,
0.00022646064,
-0.011000448,
0.023903817,
0.009371235,
0.001008483,
0.03779775,
-0.0012202808,
0.009970785,
-0.017673705,
0.0032437637,
0.015066965,
-0.0052460665,
0.0017693256,
0.0025024717,
0.006699325,
-0.0027175278,
0.009488538,
0.002412865,
-0.009703594,
-0.0018149436,
0.0018361233,
0.019967638,
0.051039994,
0.0032307298,
0.014284942,
-0.0093191,
0.003688539,
-0.017621571,
-0.004851797,
0.008126516,
0.02166202,
-0.0075986506,
-0.017204491,
-0.016083593,
-0.039831005,
0.00019723663,
0.025845839,
-0.03594696,
0.0057576397,
0.010218426,
0.017243594,
0.0018947751,
0.007813707,
0.015549212,
-0.030915951,
-0.01455865,
0.03899685,
0.023760445,
-0.0030645502,
-0.0023069659,
-0.015249436,
0.00095064595,
0.004424943,
0.012792583,
0.025298424,
0.008595729,
0.010583369,
-0.006611347,
-0.0279964,
-0.002222247,
0.008445841,
-0.0026018536,
0.020267412,
-0.013528987,
-0.0037830332,
-0.012512358,
-0.0070838192,
-0.011104718,
0.019954603,
0.0011013482,
-0.006194269,
-0.026223816,
-0.025337525,
-0.030316401,
0.007852808,
-0.014623818,
0.008328538,
0.011971459,
0.017191458,
0.001749775,
0.0071685384,
0.0020528086,
0.031150557,
0.0148714585,
0.0029146625,
-0.021088537,
0.01607056,
-0.035582017,
0.016617976,
0.0209582,
-0.002018595,
-0.005953145,
0.003079213,
-0.011026516,
-0.020006739,
-0.027553255,
0.021049436,
-0.00068264036,
-0.0049658422,
-0.0048843813,
0.0017383705,
0.0011469661,
0.0020886513,
0.022574378,
-0.0017448874,
-0.012408088,
-0.0070251673,
-0.008191684,
0.0004158567,
-0.004033932,
0.03988314,
0.008093932,
0.03284494,
-0.0020902806,
0.023134828,
0.029430108,
0.007761572,
-0.016448537,
-0.02391685,
0.029299771,
0.00008889395,
-0.0122516835,
-0.016044492,
-0.028439546,
-0.005799999,
-0.009384268,
0.009097527,
0.012323369,
0.00813955,
0.025897974,
0.025298424,
0.008954156,
-0.0012056178,
0.006621123,
0.0102314595,
0.017595503,
0.01304674,
-0.02261348,
0.03756314,
-0.011358875,
-0.00018420293,
-0.011717302,
-0.0056892126,
-0.039857075,
-0.0027175278,
-0.010746291,
0.01014674,
0.003323595,
-0.0064288755,
-0.022339772,
0.011795504,
-0.00768337,
0.0042098872,
-0.0011510391,
-0.009638426,
-0.03949213,
-0.0130597735,
-0.0150799975,
0.019615728,
-0.036207635,
-0.021740222,
0.021257974,
0.014115504,
0.021479547,
0.0011127527,
0.00038266147,
-0.0033855052,
0.025832806,
-0.008836852,
-0.0053307856,
-0.0047084265,
-0.040847633,
0.009293033,
-0.023095727,
-0.0046302243,
-0.010857077,
-0.013515953,
0.00530146,
0.016539773,
-0.014245841,
0.0021880334,
0.0054578646,
-0.0024780333,
0.009644942,
0.011893257,
-0.009866515,
-0.018872807,
-0.000113535796,
-0.008693482,
-0.02518112,
-0.027631456,
0.0014491852,
-0.011925841,
-0.0056826957,
0.000115165014,
0.008393707,
-0.024399098,
-0.011606515,
0.030759547,
-0.013346515,
-0.009820897,
0.0016398032,
0.01259056,
0.02489438,
-0.018403593,
0.012062695,
0.016253032,
-0.009625392,
0.00065535103,
0.0067775273,
0.01656584,
-0.0046725837,
-0.023199996,
-0.018025616,
-0.026406288,
-0.014232807,
-0.0071750553,
-0.004421685,
-0.019263817,
-0.0059792125,
0.005431797,
-0.01687865,
-0.020632356,
-0.013620223,
-0.0045357295,
-0.004073033,
0.00064191,
-0.026249884,
-0.016370336,
0.007794156,
-0.0145716835,
-0.028283142,
0.022639547,
-0.034382917,
-0.007748538,
0.008947639,
-0.003942696,
0.009032358,
-0.0022874153,
-0.0007380336,
-0.0056207855,
0.00047532297,
-0.038527634,
-0.05422022,
-0.0016145504,
-0.005203707,
0.030968085,
0.020528087,
0.024985615,
0.0020267414,
0.037198197,
0.016226964,
0.0035647186,
-0.0049788756,
-0.00791146,
0.031567637,
-0.00722719,
0.02739685,
0.023056626,
0.007142471,
0.016266065,
-0.00967101,
-0.0027370784,
0.01899011,
-0.023473704,
0.00046432577,
0.0154840425,
-0.01095483,
-0.039935276,
0.0070316843,
-0.030316401,
0.013196628,
-0.024386063,
-0.006578763,
0.025076851,
0.026054379,
0.010550785,
0.011195954,
0.022548312,
-0.011072134,
-0.0016992694,
-0.024633704,
-0.015158201,
-0.011033032,
-0.029586513,
0.008706516,
0.008537077,
0.013828762,
-0.0036331455,
0.0035028085,
-0.005066853,
-0.028074604,
0.003261685,
0.010948313,
-0.013815728,
-0.011443594,
-0.014636852,
-0.028856626,
-0.023890784,
-0.012134381,
-0.010407414,
-0.017673705,
-0.003025449,
-0.00038795642,
-0.020436851,
0.0064060665,
0.0008757021,
-0.013594155,
0.0478337,
0.0034506738,
0.026458424,
-0.033157747,
0.026666963,
0.017295728,
-0.005874943,
0.0033659546,
-0.00052175554,
0.0106355045,
-0.015145167,
0.03112449,
0.036051232,
-0.0039231456,
-0.0016137357,
-0.023304267,
-0.0016894941,
-0.010133706,
-0.005027752,
0.00349955,
-0.0037243816,
-0.005233033,
-0.015027863,
-0.014884492,
-0.03717213,
-0.012844717,
-0.017256627,
0.0037504488,
0.008237302,
-0.021257974,
-0.00077713473,
0.0033496625,
0.002772921,
0.003048258,
0.01257101,
-0.0327146,
-0.026640896,
-0.015575279,
0.01536674,
-0.004828988,
-0.020084942,
0.03294921,
0.009455954,
0.015236403,
0.012701347,
-0.01857303,
-0.011248088,
0.0008675561,
-0.010179324,
0.04110831,
0.008426291,
0.008413257,
0.0074683134,
0.014584717,
0.005105954,
-0.027944265,
0.0021065727,
-0.004842022,
-0.018937975,
0.0010467696,
0.026171682,
0.012460223,
-0.033157747,
0.006992583,
-0.01849483,
-0.0037634827,
-0.023447637,
-0.022887187,
-0.016761346,
-0.01969393,
-0.009240897,
-0.010303144,
0.002047921,
0.020984266,
0.00042074433,
0.0023819099,
-0.021297075,
0.030446738,
-0.023838649,
0.029299771,
0.0037928084,
0.013183594,
-0.01695685,
0.0014622189,
-0.019224716,
-0.02810067,
-0.014089436,
-0.021414379,
-0.024216626,
-0.035503816,
-0.004828988,
-0.00291955,
0.002955393,
-0.008237302,
0.01723056,
0.02025438,
0.007944044,
-0.00084393244,
0.009970785,
0.011274156,
-0.017582469,
-0.00979483,
0.014480447,
-0.001424747,
-0.02292629,
-0.00710337,
0.0031948872,
-0.0064158416,
-0.011169886,
-0.00026047046,
-0.028335277,
0.02145348,
-0.032766737,
0.026875501,
-0.016331233,
-0.008126516,
0.0005848876,
0.024138425,
0.010993931,
-0.010029437,
-0.0067775273,
0.02190966,
-0.019824266,
-0.017308762,
-0.037015725,
0.005552359,
0.00013868678,
-0.025676401,
-0.007266291,
-0.0068101115,
-0.039127186,
0.021831458,
-0.009677527,
-0.016617976,
-0.028022468,
0.0037243816,
-0.054741565,
-0.031046288,
-0.007305392,
-0.0041284263,
-0.01097438,
0.0073835943,
-0.013346515,
0.007142471,
0.0013465447,
0.0020202245,
0.005995505,
-0.04712988,
-0.009234381,
-0.026275951,
0.020137075,
0.018455727,
-0.032193255,
-0.02352584,
0.03829303,
0.0010508426,
-0.012492808,
0.01702202,
-0.033157747,
0.009077976,
-0.008537077,
-0.012890335,
-0.0053079766,
0.017660672,
0.014728088,
-0.0115934815,
0.015327638,
0.026184715,
0.02321303,
-0.0042261793,
-0.013385616,
0.0030189322,
-0.0023493255,
-0.0019697188,
-0.0022548311,
-0.018364491,
0.017738873,
-0.018142918,
-0.0061128084,
0.033235952,
-0.007448763,
0.03336629,
0.023851682,
-0.02381258,
-0.014715054,
-0.0036038198,
-0.006096516,
0.0029896062,
-0.0009864887,
0.011313257,
-0.03417438,
0.0056826957,
0.009325617,
-0.030603142,
-0.002947247,
-0.0064288755,
-0.0022059549,
-0.022795953,
0.019498425,
0.021675054,
-0.032401793,
-0.015679548,
-0.012636178,
-0.024881344,
-0.015835952,
-0.0052753924,
0.0013033706,
-0.016474605,
-0.015640447,
-0.00687528,
0.002574157,
0.0016332862,
-0.008256853,
-0.006744943,
-0.009638426,
0.029247636,
0.20228311,
-0.025402693,
-0.021049436,
0.010062021,
0.014715054,
-0.011254605,
-0.00087733136,
0.006096516,
-0.0033366287,
0.017947413,
0.018703368,
-0.0053731455,
-0.0024096065,
-0.00043744376,
0.012896853,
-0.014297975,
-0.013933032,
-0.011450111,
-0.017321795,
-0.027031906,
-0.005532808,
0.006386516,
0.018911907,
0.004076292,
0.03000359,
-0.01271438,
-0.017399998,
0.00909101,
0.01776494,
-0.024099322,
-0.027266514,
0.03464359,
-0.0017937638,
-0.007272808,
0.007005617,
0.026979772,
-0.014219773,
-0.020762693,
0.00097589876,
-0.037250333,
-0.0016283987,
0.010733257,
-0.020006739,
0.026458424,
0.015523144,
0.004819213,
-0.0093191,
0.007663819,
-0.02497258,
-0.004076292,
-0.046165388,
0.0075921337,
0.012088763,
0.020879997,
-0.0046953927,
-0.026041346,
0.021114605,
0.016995953,
-0.013568088,
0.030915951,
-0.009749212,
0.01049865,
-0.02638022,
0.026640896,
-0.013789661,
0.01768674,
-0.010596403,
-0.014884492,
-0.0124015715,
0.010003369,
0.009234381,
0.0012471627,
0.011619549,
-0.013841796,
0.003675505,
-0.011619549,
0.024255726,
-0.004499887,
0.008113482,
0.04480988,
0.006966516,
-0.015027863,
-0.03464359,
-0.014715054,
-0.019537525,
-0.0279182,
0.015106065,
0.0067775273,
-0.0061519095,
-0.0010760954,
0.008308988,
-0.008106966,
-0.0045650555,
-0.0091822455,
0.012199549,
0.016239997,
-0.012883819,
-0.0039068535,
-0.00896719,
0.0049299994,
-0.037667412,
0.0675146,
-0.0010932022,
-0.01702202,
-0.009416853,
0.0032372468,
0.0028022467,
0.012173481,
0.005294943,
0.017399998,
0.0034343814,
-0.018507862,
-0.009710111,
-0.012134381,
0.00051320216,
0.028778423,
0.009195279,
-0.015796851,
0.0150799975,
-0.019407189,
-0.011384943,
-0.01884674,
0.0030417412,
0.016096627,
-0.014376177,
0.0154840425,
-0.030498872,
0.0017302245,
-0.012968537,
-0.02961258,
0.001559157,
-0.000809719,
-0.009117077,
0.02739685,
0.016396401,
0.016396401,
0.0152755035,
-0.027344715,
-0.016800446,
0.023160895,
-0.014675953,
-0.012492808,
-0.0073835943,
0.0057511227,
0.010759325,
-0.010198875,
0.006533145,
-0.0065885386,
-0.029143367,
-0.0054187635,
-0.011684718,
-0.009521122,
-0.008497977,
-0.0141676385,
0.015392807,
-0.027266514,
-0.014819324,
-0.012056178,
0.008413257,
0.012564492,
-0.026262918,
0.014715054,
0.023721345,
0.012056178,
0.0056435945,
0.0010638762,
-0.16193077,
0.0010915729,
0.018481795,
-0.02433393,
0.020137075,
0.03341842,
-0.018716402,
0.00093924144,
-0.004897415,
0.0026099996,
0.03102022,
0.01793438,
-0.03313168,
0.0036689884,
0.019759098,
0.01002292,
0.002147303,
0.024177525,
0.0148714585,
0.007370561,
0.024138425,
-0.008667415,
-0.010140223,
0.004125168,
-0.0017628088,
0.016213931,
0.014988762,
0.00075554766,
-0.005835842,
-0.0027028648,
-0.013001122,
0.024451233,
0.023186963,
0.016500672,
0.011560897,
0.008426291,
-0.003835168,
0.004903932,
0.00034132018,
0.0027289323,
0.0148714585,
0.0046693254,
0.008113482,
-0.00054945215,
-0.024490334,
0.016513705,
0.007676853,
0.0020576965,
0.029899321,
0.011958425,
0.03013393,
-0.01294247,
0.011938875,
0.019420221,
0.0005685954,
0.019850334,
0.017960448,
0.021271009,
-0.0010182583,
0.006249662,
0.0041675274,
-0.037302468,
0.0021880334,
0.012225617,
-0.0042620217,
-0.04441887,
-0.01969393,
0.009449437,
-0.018090785,
0.005089662,
-0.025937075,
0.010583369,
0.03193258,
-0.019498425,
0.012557976,
0.020984266,
0.0016308425,
0.011860672,
0.0020430335,
0.014428313,
0.002261348,
0.0061160666,
-0.03313168,
-0.011671684,
0.0052428083,
0.005154831,
0.024764042,
0.007044718,
-0.011430561,
-0.0063995495,
0.02054112,
-0.013698425,
-0.015875055,
-0.0076573025,
0.040222015,
0.029795052,
-0.004382584,
-0.0029374715,
-0.013646291,
-0.0067319092,
0.015848987,
-0.016370336,
-0.03302741,
0.017817076,
0.028283142,
-0.013776627,
-0.0315155,
0.0027452244,
0.059902914,
-0.021362245,
-0.010557302,
-0.009703594,
0.026275951,
0.006213819,
0.00851101,
0.025128985,
0.01670921,
0.0020886513,
-0.008165617,
-0.0163573,
0.053646736,
0.011326291,
0.0021293818,
0.012662246,
-0.0001044733,
-0.008048314,
-0.12929437,
-0.020801796,
-0.003698314,
-0.006598314,
-0.0372764,
0.01165865,
-0.026575727,
0.010589886,
-0.03526921,
0.019719997,
0.007448763,
-0.0044575273,
-0.017256627,
-0.018390559,
0.03857977,
-0.019433256,
-0.0019550559,
-0.00016546698,
-0.012095279,
0.021466514,
0.003247022,
-0.0061551677,
0.011938875,
-0.015288537,
0.020097975,
0.004170786,
-0.022704717,
0.02770966,
0.006663482,
0.009416853,
-0.018872807,
0.012727414,
0.031880446,
-0.0032095502,
-0.018299323,
-0.012069212,
0.015132133,
-0.029299771,
0.040951904,
-0.025128985,
0.0015420504,
0.0209582,
0.012297302,
0.00079139037,
-0.0067905607,
-0.019120447,
-0.052160893,
-0.00594337,
0.023643143,
-0.019420221,
-0.011150336,
-0.015848987,
0.0027598874,
0.0008040167,
0.0025334265,
-0.016239997,
0.012069212,
0.040065613,
-0.0074357293,
0.011554381,
-0.0014809548,
0.008256853,
-0.0145716835,
0.019876402,
0.023604041,
-0.021675054,
0.010765841,
-0.0361555,
0.020215278,
-0.005174381,
-0.0024845502,
-0.0061095497,
-0.019993706,
-0.028491681,
-0.02549393,
-0.0028136512,
-0.00048550556,
0.00027879913,
0.021818424,
-0.032584265,
-0.023955952,
-0.0049137073,
0.019420221,
-0.031880446,
0.011665167,
0.006907864,
0.019928537,
-0.007944044,
0.012017077,
-0.015940223,
0.00058325834,
0.049423814,
-0.0028169097,
-0.026288984,
-0.0032958984,
0.0046237074,
0.0030205613,
0.018911907,
0.00635719,
0.012160447,
-0.01315101,
-0.01642247,
-0.05468943,
0.030029658,
-0.002575786,
0.01176292,
0.00838719,
-0.016800446,
0.017139323,
-0.00021790728,
0.0044803363,
0.029586513,
-0.011215504,
0.022535278,
-0.011430561,
0.006119325,
-0.0026230332,
0.013053257,
0.016200896,
-0.0037178646,
0.0061323587,
0.026106514,
-0.0008390448,
-0.00733146,
-0.0001841011,
-0.00065535103,
-0.0034930331,
0.017921345,
-0.0011738482,
0.034904264,
-0.017777976,
0.01614876,
0.004799662,
-0.03555595,
-0.013698425,
-0.002077247,
-0.02810067,
-0.01410247,
-0.008550111,
0.031880446,
0.015171234,
0.01990247,
-0.010198875,
-0.03506067,
0.0019664604,
-0.0032502804,
0.0018898874,
0.0061682016,
-0.028048536,
0.009723145,
-0.0062757293,
-0.010687639,
0.017947413,
0.005057078,
0.016292132,
-0.043297973,
-0.01049865,
-0.0087195495,
-0.005500224,
-0.015536178,
-0.017895278,
-0.02932584,
-0.0076898867,
0.035321344,
0.002246685,
0.01938112,
0.02025438,
-0.005063595,
-0.004776853,
0.00004029757,
-0.003721123,
-0.032062918,
-0.011189437,
-0.017048087,
-0.010791909,
-0.009104043,
-0.014754156,
0.0045259544,
-0.025415726,
0.03334022,
0.0021668538,
0.026262918,
0.00074414315,
-0.0068817968,
-0.02170112,
0.01948539,
0.026275951,
0.012023594,
-0.009025841,
0.009742695,
-0.0037341567,
0.00552955,
-0.0048778644,
0.020319548,
0.028022468,
0.00081827235,
0.020384716,
0.015692582,
-0.009403819,
0.0046399995,
-0.02039775,
0.047260217,
0.0029081458,
0.0063148304,
-0.008048314,
-0.020580223,
-0.017738873,
0.00967101,
-0.053855274,
-0.025155053,
-0.019615728,
0.031802244,
0.008660898,
0.025819771,
0.017751908,
-0.01596629,
-0.022066064,
0.00635719,
-0.008589212,
-0.004424943,
-0.010048987,
0.023695277,
0.0057478645,
0.0064582014,
0.018951008,
0.0042326963,
0.0036070782,
0.0049560666,
0.035920896,
-0.035894826,
0.015210335,
-0.011391459,
0.02602831,
0.012668762,
-0.04131685,
-0.007409662,
-0.0012862639,
-0.025441794,
0.008713032,
0.026875501,
-0.012903369,
0.06860943,
-0.0044803363,
-0.04061303,
0.013385616,
-0.017139323,
0.017543368,
0.009820897,
0.012316852,
0.0012357583,
-0.036624715,
0.00793101,
-0.020971233,
0.011332807,
-0.055262912,
-0.012629661,
0.021779323,
-0.0011901403,
-0.0030596624,
0.013698425,
-0.011261122,
0.0025171344,
-0.011573931,
-0.0009376122,
0.03341842,
-0.05309932,
0.010492133,
0.0419164,
0.005503482,
-0.018129885,
-0.040013477,
0.00074088475,
0.0056044934,
-0.022822019,
-0.012988088,
0.01410247,
-0.011925841,
-0.025259322,
-0.0131053915,
0.008087414,
0.012199549,
-0.012036627,
0.0061779767,
-0.035790555,
-0.009644942,
0.009807864,
-0.01385483,
-0.010915729,
-0.012720897,
-0.0039003366
] |
Induced pluripotent stem cells (iPSCs) hold great promise as a cell source for regenerative medicine yet its culture, maintenance of pluripotency and induction of differentiation remain challenging. Conversely, graphene (G) and graphene oxide (GO) have captured tremendous interests in the fields of materials science, physics, chemistry and nanotechnology. Here we report on that G and GO can support the mouse iPSCs culture and allow for spontaneous differentiation. Intriguingly, G and GO surfaces led to distinct cell proliferation and differentiation characteristics. In comparison with the glass surface, iPSCs cultured on the G surface exhibited similar | [
-0.0017257765,
0.006403674,
0.0056476844,
-0.022043416,
-0.011288527,
-0.002974356,
-0.024082193,
0.0077240895,
-0.02308333,
-0.025423132,
0.013402561,
0.009502888,
-0.013956726,
0.00504563,
-0.007826713,
0.021783438,
0.015352397,
-0.006441302,
-0.010871194,
0.033797167,
-0.038367312,
0.017678518,
0.014654562,
-0.021140333,
-0.006838111,
0.003814154,
0.011144856,
-0.008367194,
-0.0062839473,
0.00058452337,
0.0049156407,
0.0035986458,
-0.021756072,
0.01049491,
-0.01174691,
-0.0063421,
0.0023791427,
-0.012314757,
0.0064207776,
-0.0107069975,
0.0055621653,
0.010919085,
-0.0046419795,
0.00906503,
0.011575872,
0.0106385825,
-0.020237252,
0.0006944155,
0.006533663,
0.017322758,
0.017856399,
0.01657019,
-0.0031847332,
-0.004706974,
-0.01960783,
-0.013169949,
0.01022809,
0.004535936,
0.0015932218,
-0.0066328654,
0.013908834,
0.004313586,
-0.011014867,
0.016419677,
-0.010323872,
0.012451588,
-0.017746935,
-0.0023192794,
-0.0025707057,
-0.012670517,
0.025382083,
0.014613512,
-0.008066166,
-0.0176922,
-0.007744614,
-0.015831305,
-0.035849627,
-0.01755537,
0.0063968324,
0.020415131,
0.012978386,
-0.035220206,
0.007265707,
0.008654538,
0.0023586182,
0.0262578,
-0.0030256675,
0.010084418,
0.004224646,
-0.012273708,
0.028296577,
0.039379857,
0.03760106,
0.0059726574,
-0.016132332,
0.004864329,
-0.0102486145,
0.023616968,
-0.0019806235,
-0.024711613,
-0.0004021538,
0.02371275,
0.004518832,
-0.025669428,
-0.03604119,
-0.010426494,
0.030130107,
-0.020018322,
0.014476682,
0.0140935555,
-0.008880309,
0.023603285,
0.008285095,
-0.004775389,
0.017035415,
0.00092104124,
0.009051347,
0.012198452,
-0.013813053,
-0.021687657,
0.01152114,
-0.002888837,
0.025628379,
-0.026216751,
-0.009687609,
0.012841555,
-0.03730003,
0.005086679,
-0.0066431277,
-0.010823304,
0.031471048,
-0.0067731165,
0.0011126042,
0.03647905,
-0.012232659,
-0.0050832583,
-0.020237252,
-0.012047938,
-0.010748046,
-0.03023957,
-0.016282845,
0.017979546,
0.008497182,
0.0045393566,
-0.015803939,
0.010303347,
0.02710615,
-0.0012451588,
0.020250935,
0.022987548,
0.013204156,
0.0034361593,
0.023124378,
0.017473273,
-0.007744614,
0.02353487,
0.0017839294,
0.021509776,
-0.013087851,
0.008401401,
0.0150650535,
-0.03620539,
0.00051097694,
0.006109488,
-0.003309591,
0.027927134,
-0.00014891021,
0.010111785,
0.0008607502,
-0.015968136,
-0.01348466,
0.042280667,
-0.034180295,
0.017076464,
0.00504563,
0.022481274,
-0.008483499,
0.02826921,
-0.00786092,
-0.02389063,
0.0023551974,
0.020086737,
0.011863217,
0.013505184,
-0.0062497393,
-0.011370626,
0.032593057,
0.021496093,
-0.00073204393,
-0.023001231,
-0.0106933145,
0.0021602137,
-0.00513457,
-0.013436769,
-0.63182914,
-0.046823446,
0.011103806,
-0.012218976,
0.039544053,
0.031279486,
0.02523157,
-0.0049566897,
-0.014832442,
0.017350124,
-0.008120898,
0.0028614707,
0.0030650063,
-0.0041459682,
-0.0044914656,
-0.021728706,
0.0121095115,
-0.013361512,
0.02112665,
0.0017873502,
-0.03371507,
-0.01714488,
-0.005651105,
0.0140661895,
0.0052577173,
0.022795985,
0.014681928,
-0.0037765256,
-0.025532598,
0.036725342,
-0.03171734,
0.017117513,
0.0047924933,
0.012868921,
0.048739072,
0.005746887,
-0.03710847,
0.027352445,
0.0048301215,
0.05270716,
-0.025108423,
0.0066704936,
0.008339828,
0.0022799405,
-0.016720705,
0.018075328,
-0.0021585033,
0.0030000117,
-0.0050353673,
0.00325999,
0.0014606671,
0.005828985,
-0.017035415,
0.019717295,
0.021728706,
-0.009304483,
0.0071699256,
-0.00308211,
0.02509474,
0.008141423,
0.015106102,
0.015749207,
-0.03371507,
-0.046522416,
-0.01397725,
0.038339946,
-0.030868992,
-0.005873455,
0.026216751,
-0.008490341,
-0.0009355795,
0.03130685,
-0.028050281,
-0.00038504996,
-0.011596397,
0.033414043,
0.016652288,
0.007614625,
0.0047411816,
0.006649969,
0.006903106,
-0.00647551,
-0.011637446,
0.009448156,
0.034809716,
-0.006239477,
-0.017651152,
0.0060684388,
-0.008161948,
-0.0013956726,
0.016173381,
0.021208748,
0.0037115312,
-0.043430045,
-0.010392287,
0.017404858,
-0.016091283,
0.0005344947,
0.0056442637,
-0.010337555,
-0.022344444,
0.014216703,
0.0021550825,
0.017514322,
0.01710383,
0.009803915,
-0.03667061,
-0.0106796315,
0.030704794,
-0.036561146,
0.0029914598,
0.0010347817,
0.01161008,
-0.019265754,
0.00020663564,
-0.022180246,
0.012930496,
-0.012143719,
-0.011329577,
-0.035603333,
0.00428622,
-0.008319302,
-0.006372887,
0.016488092,
0.01165797,
0.009564462,
-0.006502876,
-0.013436769,
-0.018608967,
0.010022844,
-0.009188177,
-0.014586146,
0.0052816626,
-0.033222478,
0.028789166,
0.019703612,
0.0008359497,
-0.0051516737,
0.005309029,
-0.025915723,
-0.035083376,
-0.00030273778,
0.004587247,
-0.006974942,
-0.009831281,
0.0056168977,
-0.021099284,
-0.01205478,
0.004033083,
-0.0071836086,
0.014654562,
-0.0027571374,
-0.0004626586,
0.007792505,
0.01960783,
-0.0022902028,
-0.011527982,
-0.011623763,
-0.0026904324,
-0.003858624,
-0.032073103,
0.022317078,
-0.006003444,
-0.016501775,
0.01880053,
-0.0337698,
-0.022207612,
0.030184839,
-0.0024013778,
-0.024930542,
-0.0026989845,
-0.021304531,
0.009714975,
0.0141072385,
0.0007842106,
-0.0052542966,
-0.0014897436,
0.0046932907,
0.0010373472,
-0.015311348,
-0.0042656953,
-0.017993229,
0.00656445,
-0.009010297,
0.021359263,
0.0045530396,
0.03743686,
0.029856445,
-0.001857476,
0.026627243,
0.0014726397,
0.030513233,
-0.016091283,
-0.0010245194,
-0.006865477,
-0.026380947,
-0.019717295,
-0.0022645472,
0.004395684,
0.015708158,
0.030321669,
0.008469816,
0.030567965,
-0.03470025,
0.037464228,
-0.023644334,
0.005185881,
-0.003992034,
0.002392826,
0.01907419,
0.0002512125,
0.020647744,
-0.028460773,
-0.026120968,
0.0044640996,
-0.0074025374,
-0.013293097,
-0.014298801,
0.0005315015,
-0.009578145,
-0.009386581,
0.012362648,
0.017514322,
-0.008989773,
-0.011459566,
0.032757256,
0.008387718,
0.024930542,
0.00786092,
-0.016063917,
-0.0039407224,
0.004925903,
0.00092959317,
-0.012909971,
0.0220571,
0.032839354,
0.022549689,
-0.027366128,
0.044278394,
-0.0031642085,
0.00014442047,
0.0049669524,
0.017664835,
0.0046419795,
-0.007019412,
-0.008134581,
0.029008096,
-0.0005935029,
-0.039379857,
0.022111831,
-0.033660337,
0.0131220585,
-0.0279545,
0.015147151,
0.029500686,
-0.009817598,
0.011425358,
0.007819871,
0.01286208,
0.011356943,
-0.0061573787,
-0.017924814,
0.0121095115,
-0.026421996,
-0.023233842,
-0.00058922695,
0.013819895,
-0.0005456122,
-0.024971591,
-0.009906538,
-0.015776573,
-0.003697848,
0.028488139,
-0.01804796,
-0.0064378814,
-0.0013768583,
0.014517731,
-0.006177903,
-0.0003918915,
0.009810757,
-0.0016676234,
-0.020127786,
0.0032976184,
0.013813053,
0.00020898742,
-0.0063249962,
-0.031553145,
-0.014572463,
-0.015516594,
-0.011117489,
0.0018318202,
-0.0027930555,
0.010063893,
0.0031659189,
-0.017268026,
-0.028187111,
-0.00017777293,
-0.0033745856,
0.02148241,
0.022289712,
0.018157426,
0.0039133565,
-0.026736706,
-0.0061607994,
0.025792575,
-0.0032719627,
-0.0015581589,
-0.0040570283,
0.0029897494,
-0.026230434,
-0.006177903,
-0.009673926,
0.009277117,
-0.005305608,
0.0072451825,
-0.0054561216,
0.0029914598,
-0.010344396,
0.041952275,
-0.0055074333,
-0.013156266,
-0.027092466,
-0.0021944214,
-0.014298801,
0.030923724,
0.021017186,
-0.009188177,
0.01044702,
0.01290313,
0.0011570741,
0.0010356369,
-0.02487581,
0.0039646677,
-0.021181382,
0.0015384895,
0.0069646793,
0.00616422,
-0.021331897,
0.008825576,
0.025176838,
-0.024574783,
-0.026421996,
-0.009981795,
-0.0014333009,
0.0118769,
0.0008128595,
-0.0065405047,
0.017322758,
0.033797167,
0.006441302,
0.012896287,
0.017391175,
-0.018691065,
-0.009126604,
-0.023329623,
-0.00084663957,
0.011206429,
-0.014148288,
-0.016022868,
-0.038695704,
0.032483593,
0.016488092,
0.0013939622,
0.017486956,
0.0060171275,
0.0088461,
0.008469816,
-0.014599829,
-0.0026339898,
-0.012992069,
-0.017268026,
-0.0107206805,
-0.021386629,
-0.017541688,
0.019703612,
-0.017418541,
-0.002049039,
0.0006140275,
0.0072725485,
0.0064549856,
-0.009851806,
-0.010043369,
0.004296482,
-0.022782302,
0.00888715,
-0.028789166,
-0.0030410609,
-0.0019754923,
-0.017651152,
-0.045236208,
0.018691065,
-0.035658065,
-0.016939633,
0.004395684,
0.032839354,
-0.018006912,
-0.03582226,
0.006099226,
0.004207542,
0.013368353,
0.010604374,
-0.015448179,
-0.018075328,
0.027708204,
0.01031703,
-0.033304576,
-0.0005498881,
-0.007854079,
0.023781165,
0.021509776,
0.002777662,
0.009543937,
-0.008059325,
-0.0069681,
0.021386629,
-0.01058385,
-0.024355853,
0.013402561,
-0.004033083,
0.014695611,
0.020291984,
0.006725226,
0.002442427,
-0.01165797,
0.0022782302,
-0.011322736,
-0.024164291,
-0.02933649,
-0.010118626,
0.01420302,
0.00049515587,
-0.0017232109,
-0.026052553,
-0.0065576085,
0.021071918,
-0.010823304,
0.021933952,
-0.0082508875,
0.0068073245,
0.005873455,
-0.011548506,
0.017185928,
-0.0063934117,
-0.023945361,
-0.012766299,
-0.0017582737,
0.028925996,
0.005305608,
-0.017295392,
0.0025467603,
0.003143684,
-0.006301051,
-0.023945361,
-0.007977226,
-0.009386581,
0.032127835,
-0.009099238,
-0.019498367,
0.013867785,
-0.00080559036,
-0.011911107,
-0.0026220172,
-0.011062757,
-0.009803915,
-0.0072451825,
0.008770844,
0.029856445,
-0.015366081,
0.013190473,
-0.040036645,
-0.013163107,
0.008073008,
0.013854102,
-0.010960134,
-0.014722977,
-0.006126592,
-0.026148336,
-0.021112967,
-0.023411723,
-0.020428814,
-0.009010297,
-0.02982908,
0.046194024,
0.02452005,
0.036232755,
0.002957252,
0.01621443,
0.00821668,
-0.005637422,
-0.0018694486,
-0.0035165474,
-0.002461241,
-0.028105013,
0.013833578,
-0.002988039,
-0.001987465,
0.012362648,
-0.019936224,
-0.013053643,
0.005623739,
-0.014476682,
-0.0032428862,
0.007498319,
-0.04997055,
-0.045619335,
0.019908858,
-0.0056340015,
-0.0053295535,
-0.027721887,
0.0047924933,
0.021195065,
0.007163084,
0.013402561,
-0.0029008095,
0.0211677,
-0.004618034,
0.02840604,
-0.000703395,
0.01192479,
-0.022837033,
-0.00862033,
-0.017473273,
-0.011356943,
0.004939586,
-0.0018831317,
0.026408313,
0.014586146,
0.0106385825,
0.0001302029,
0.021372946,
-0.027680838,
-0.0025826783,
0.00460093,
-0.053035557,
-0.008675062,
-0.024807395,
-0.005439018,
-0.0245611,
-0.016871218,
0.013929359,
-0.02406851,
0.018499503,
-0.020962454,
-0.0237538,
0.039051466,
0.008586123,
0.014271435,
-0.013642015,
0.011637446,
0.028652336,
0.0021191644,
-0.013375195,
-0.0150240045,
0.0061197504,
-0.0031009244,
0.026681975,
0.0071699256,
-0.0017437355,
-0.035740163,
-0.020209886,
0.01986781,
-0.01745959,
-0.022234978,
0.0067354883,
-0.0038073126,
-0.00196523,
-0.02594309,
-0.0040159794,
-0.028953364,
0.027147198,
0.009441314,
0.0106796315,
-0.011822167,
-0.014285118,
-0.025888357,
0.025258936,
0.007730931,
0.026791438,
0.004484624,
0.026764072,
-0.01759642,
-0.026011504,
0.011103806,
0.017705884,
0.008969248,
0.002580968,
-0.017076464,
0.00034891814,
0.00047719685,
0.0014581014,
0.013949884,
0.003783367,
0.017473273,
0.040392406,
-0.007019412,
-0.0016453884,
0.025135789,
-0.008114057,
0.020565646,
-0.031936273,
-0.0054150727,
0.013169949,
-0.031033188,
-0.0035233889,
0.02081194,
0.013628332,
-0.008948724,
-0.0019908857,
-0.0055792695,
-0.023138061,
-0.041897543,
-0.034125563,
0.009386581,
-0.018472137,
-0.006123171,
0.005278242,
0.004009138,
0.0014863228,
-0.0064686686,
0.0039988756,
0.0048301215,
0.03117002,
-0.011021708,
0.025860991,
0.032401495,
0.0016051944,
-0.019772027,
0.01951205,
0.006974942,
-0.03992718,
0.0015624348,
-0.016378628,
-0.036369585,
-0.029144926,
-0.011350102,
-0.0029983013,
0.0035165474,
0.0087503195,
0.009092396,
0.01996359,
0.02322016,
-0.0082508875,
-0.01986781,
-0.0010467544,
-0.010960134,
0.005076417,
0.013402561,
-0.018663699,
-0.020729842,
0.0030650063,
-0.0023124379,
0.00062856573,
-0.029801713,
-0.008408243,
-0.014640878,
-0.0082372045,
-0.012088987,
0.005610056,
0.008962407,
-0.0017873502,
-0.0141072385,
-0.01335467,
0.022713887,
0.005387706,
-0.026285166,
0.0066704936,
0.01657019,
0.016228113,
-0.024054827,
0.014476682,
-0.013778846,
-0.027612424,
-0.032647792,
0.014750343,
0.0047411816,
0.044661522,
0.020510912,
-0.0047446024,
-0.04178808,
-0.006136854,
-0.04537304,
-0.02296018,
0.007922494,
0.021509776,
0.001688148,
0.003465236,
-0.0024150608,
-0.0042178044,
0.0015119786,
0.008346669,
-0.011459566,
-0.017377492,
0.026011504,
-0.016460726,
0.01678912,
0.014161971,
-0.04113129,
-0.021947635,
0.032401495,
-0.0018557656,
0.0049190614,
0.012362648,
0.02799555,
0.032456227,
-0.019813076,
0.012882604,
0.020155152,
0.018376354,
0.016200747,
-0.021892902,
-0.00060761353,
-0.0043820012,
-0.015940769,
0.003858624,
0.008558757,
-0.023876946,
-0.0037457386,
0.0097081335,
-0.0012939047,
-0.015215567,
0.00051012175,
0.014805075,
-0.0005652816,
-0.01907419,
0.023685383,
0.018636333,
0.006013707,
0.008421926,
-0.017623786,
0.0051243072,
-0.004077553,
-0.018390037,
0.009058189,
-0.02509474,
-0.02657251,
0.011452724,
-0.0047001326,
-0.034235027,
-0.0101665165,
-0.0097081335,
-0.0048335423,
-0.009790232,
0.027981866,
0.0018831317,
-0.011363785,
-0.015393447,
-0.008716112,
-0.000562716,
-0.029281756,
-0.0006559319,
-0.016419677,
-0.02067511,
0.002353487,
-0.006851794,
-0.0106796315,
0.005059313,
0.012417381,
0.016447043,
-0.0024937384,
0.0021875799,
0.19824024,
-0.0039988756,
0.034180295,
0.025299985,
0.00312658,
-0.024013776,
0.021988684,
-0.019019458,
0.011288527,
0.017432224,
0.018513186,
-0.0052440343,
-0.027133515,
-0.014038824,
0.018362671,
-0.008777685,
-0.020962454,
-0.0055313786,
-0.026941953,
0.0035678588,
0.017746935,
-0.026298849,
0.019211022,
-0.004898537,
-0.004193859,
-0.002835815,
-0.015680792,
0.000034074037,
0.019252071,
0.026230434,
-0.004299903,
0.013169949,
-0.0102486145,
0.011897424,
0.030896358,
0.012444747,
0.01362149,
-0.01558501,
0.009769708,
0.0121095115,
0.015461862,
0.028597603,
-0.019416267,
0.00799091,
0.0059418706,
0.039516687,
-0.000785921,
0.01871843,
0.018034277,
0.006578133,
-0.035876993,
0.024191657,
0.02103087,
0.019525733,
-0.00023389487,
0.0067628543,
-0.0060171275,
-0.0069065266,
0.0006349797,
0.017185928,
-0.013252048,
0.017185928,
-0.012978386,
0.041240755,
-0.0033215638,
0.00012774424,
-0.0211677,
0.008558757,
-0.015708158,
-0.013915676,
-0.022234978,
-0.0017454459,
-0.0143809,
0.0050661545,
-0.003295908,
-0.03442659,
0.03251096,
0.0027605582,
0.005161936,
0.017090147,
-0.00033715923,
0.011534823,
-0.039106198,
0.0019053667,
-0.026148336,
-0.02840604,
0.029363856,
-0.004327269,
-0.034837082,
-0.010843828,
0.013737796,
0.0040022964,
-0.013443611,
-0.0014179075,
-0.0053124498,
-0.016241796,
-0.010412811,
-0.001835241,
-0.001625719,
-0.0059589744,
-0.038203113,
0.06649969,
0.01455878,
0.018567918,
0.010419653,
0.016707022,
0.0017719568,
-0.004621455,
-0.011897424,
0.01303996,
0.0044162087,
-0.021112967,
0.004782231,
-0.009454997,
-0.010645424,
0.023343308,
0.021947635,
-0.019101556,
0.04389527,
-0.008510866,
-0.0023603286,
-0.016405994,
-0.013847261,
0.014818758,
-0.0080388,
-0.0039133565,
0.0012879184,
0.022891765,
-0.029500686,
-0.031553145,
-0.00687916,
-0.025518915,
0.014709294,
-0.010912243,
-0.0026288587,
0.013409402,
0.022809668,
-0.00844245,
-0.009434473,
0.0013298228,
-0.025819942,
-0.012841555,
0.004604351,
0.00076967233,
0.006930472,
-0.00021871523,
0.009591828,
0.011616921,
0.010289664,
-0.017486956,
-0.01974466,
-0.027393494,
-0.0047890726,
-0.0010655686,
0.03242886,
0.00059735123,
-0.006136854,
-0.024602149,
0.006711543,
0.02759874,
-0.02728403,
0.021071918,
0.0053808647,
-0.007176767,
-0.003684165,
-0.013149424,
-0.17361072,
0.021154016,
0.027037734,
-0.01996359,
0.016351262,
0.025997821,
0.011856375,
-0.022481274,
0.021154016,
0.004590668,
0.034016095,
0.017226977,
-0.049997915,
-0.01009126,
0.015242933,
0.007142559,
-0.020387765,
0.048328582,
0.020497229,
0.009085555,
0.005144832,
-0.017213294,
0.0038552033,
-0.008052483,
0.0029931702,
-0.015530278,
0.0059213457,
-0.013518867,
-0.025765209,
-0.042034373,
-0.00057853706,
-0.01290313,
0.021386629,
0.010016003,
0.013395719,
-0.0021995525,
-0.015242933,
-0.007320439,
-0.0027605582,
0.02692827,
0.01893736,
0.018006912,
-0.018567918,
-0.003714952,
-0.017528005,
-0.00047805204,
-0.010857511,
-0.0008120043,
0.019580465,
0.004135706,
0.025409449,
-0.01826689,
-0.004234908,
0.017445907,
0.01919734,
0.009208702,
0.028050281,
0.01228055,
-0.0044948864,
-0.0034669463,
0.0030119845,
-0.007087827,
0.026531462,
-0.0026630664,
-0.00034699394,
-0.020962454,
0.002625438,
0.015297665,
-0.018745797,
0.004686449,
-0.016912267,
0.0037560011,
0.010358079,
-0.026476728,
0.0337698,
0.0069065266,
0.0053192913,
0.002514263,
0.0005763991,
0.0018147164,
-0.022919131,
0.018513186,
-0.012971545,
-0.022412859,
-0.0076488326,
0.022618104,
0.0037765256,
0.027215615,
-0.015475545,
0.0045290943,
0.02179712,
-0.025505232,
-0.008914516,
-0.0013135741,
0.03987245,
0.026586194,
-0.016871218,
-0.028597603,
0.009263434,
-0.0072588655,
0.021071918,
-0.0060821217,
-0.019033141,
-0.0005815302,
0.043129016,
0.0049669524,
0.0033694545,
-0.002161924,
0.067047015,
-0.0058802967,
-0.028105013,
-0.0077856635,
0.0049943184,
0.041596513,
-0.020045688,
0.034536052,
-0.013156266,
0.014038824,
0.0027879244,
-0.034399223,
0.052761894,
0.0150376875,
-0.0039680884,
0.008551915,
-0.0037731049,
0.00046821733,
-0.13934833,
-0.02246759,
0.015311348,
0.018773163,
-0.01388831,
0.010980659,
-0.004864329,
0.01295102,
-0.002519394,
0.036424316,
0.0024030881,
-0.020114103,
0.019840444,
-0.013956726,
0.012711566,
0.004163072,
-0.004535936,
-0.019662563,
-0.021961318,
0.028679702,
0.017199611,
-0.0012528555,
-0.009277117,
-0.0101665165,
-0.003920198,
0.034891814,
-0.03831258,
0.03907883,
0.017226977,
0.016091283,
0.014764026,
-0.0176922,
0.019320486,
-0.009605511,
-0.012000047,
-0.00920186,
0.003157367,
-0.029637516,
0.025436815,
-0.008941882,
-0.0020268038,
0.005363761,
0.019019458,
-0.0037731049,
-0.006502876,
0.0057981983,
-0.012068463,
0.016323896,
0.0028118696,
-0.025833625,
-0.04318375,
-0.013217839,
0.0016898584,
-0.01724066,
0.030732162,
-0.025122106,
0.011719544,
0.018431088,
0.009769708,
-0.0022525743,
0.0036431157,
-0.014627195,
-0.012691041,
0.0020627219,
0.017569054,
-0.0010108363,
-0.03872307,
-0.03144368,
0.009933905,
0.0015042819,
-0.0060342313,
-0.002197842,
-0.00002856874,
0.005873455,
-0.014805075,
0.0020387764,
0.007778822,
-0.009106079,
-0.023822214,
-0.003326695,
0.0036225913,
-0.0356307,
0.010700156,
-0.020155152,
0.023835897,
0.00857244,
0.035876993,
0.009940746,
0.013635173,
-0.021646608,
-0.01951205,
0.034399223,
0.011377468,
-0.03158051,
0.01228055,
0.010960134,
-0.006256581,
-0.004631717,
0.022987548,
0.006591816,
-0.0075256852,
-0.015201884,
-0.049012735,
0.003920198,
0.0074777943,
0.0087366365,
-0.025217887,
-0.029062828,
0.0013588993,
-0.013765162,
0.007204133,
-0.008018276,
-0.014462998,
0.005213247,
-0.00812774,
0.0013375195,
-0.03171734,
-0.036424316,
0.030349035,
0.0004224646,
-0.0006503731,
0.017418541,
0.0076830406,
0.0011681915,
0.010645424,
-0.013703588,
-0.015420813,
0.032647792,
-0.013518867,
0.031991005,
-0.02268652,
-0.02961015,
0.015803939,
-0.027708204,
-0.010823304,
0.0036739027,
-0.0018814213,
-0.021673974,
0.0107069975,
0.026449362,
0.024957908,
0.034016095,
-0.007231499,
-0.028433407,
0.032894086,
0.009352374,
0.0005297911,
0.011760593,
-0.025792575,
0.012198452,
0.011117489,
-0.009037664,
0.033523507,
0.00040707114,
0.004908799,
-0.01295102,
0.003988613,
-0.02554628,
0.008989773,
0.028022915,
0.0048027555,
0.0121368775,
0.021427678,
0.01907419,
0.019361535,
-0.0068860017,
0.013012594,
-0.016378628,
-0.04397737,
-0.017062781,
-0.012800506,
-0.02410956,
-0.027585058,
0.004973794,
0.033742435,
0.02031935,
0.008401401,
0.00052594277,
-0.0030752686,
-0.008161948,
-0.0097081335,
0.020278301,
0.0061300127,
0.0030085638,
-0.03448132,
0.01880053,
0.017651152,
-0.005291925,
-0.021756072,
0.020852989,
0.003398531,
0.0024766345,
0.005551903,
0.010077576,
0.009181336,
-0.0021465307,
0.032921452,
0.0031248697,
-0.0131220585,
0.01986781,
0.0041288645,
0.032264665,
0.017541688,
0.016296528,
0.024054827,
-0.015913403,
-0.015598693,
0.024807395,
-0.032921452,
-0.033414043,
-0.00888715,
0.012533686,
0.0027041156,
0.0072246576,
-0.019033141,
0.0024509788,
-0.018882629,
0.007730931,
-0.015913403,
-0.021468727,
-0.008353511,
0.03590436,
0.025395766,
0.013115217,
-0.0026032028,
-0.007580417,
0.009838123,
-0.0126842,
0.038914632,
-0.030376403,
0.02250864,
-0.002031935,
0.018362671,
0.003206968,
-0.013272572,
-0.026298849,
-0.017979546,
-0.02491686,
-0.017199611,
0.043867905,
-0.018089011,
0.07394328,
0.02183817,
-0.023028597,
0.0066431277,
-0.022850716,
0.008599806,
-0.0021585033,
0.00067389087,
-0.035439134,
-0.036451682,
0.027147198,
-0.035001278,
0.0060308105,
-0.016624922,
-0.0015196753,
0.0111790635,
-0.0052269306,
0.027626107,
-0.024738979,
-0.0068757394,
0.017117513,
-0.004635138,
0.010200724,
0.012875763,
-0.015612376,
-0.0076351496,
0.021427678,
-0.026873538,
0.012779982,
-0.004576985,
0.008031959,
0.011103806,
-0.05131149,
-0.00879821,
-0.01371043,
0.01067279,
0.010358079,
-0.045044646,
0.0037560011,
0.020784574,
-0.013156266,
0.005411652,
-0.0026459624,
-0.017391175,
-0.017842716,
-0.008880309,
-0.02554628,
-0.004809597,
-0.0033557715
] |
Our purpose was to determine the aerobic capacities (VO2max) of a group of black female adolescents (age = 11.4-15.8 years) randomly chosen from a single urban school. Of 91 girls selected, 64 performed an incremental treadmill running test to volitional exhaustion and achieved VO2max as determined from expired gas measures. Other measures included height (m), weight (kg), and calf and triceps skinfolds (for % fat estimates). Girls were also asked whether they had achieved menarche. VO2max averaged 37.3 +/- 6.2 ml.kg-1 x min | [
-0.015953783,
-0.025489073,
0.00079653354,
-0.031458534,
-0.012625676,
0.022794891,
-0.018885687,
-0.048653755,
-0.01887248,
-0.03716386,
0.00783822,
0.029979376,
0.0179348,
-0.017578216,
-0.019955436,
0.00814858,
0.02799836,
-0.0037210085,
0.0032340088,
-0.02017995,
0.007765583,
0.021434594,
-0.021645902,
0.01612547,
-0.013933146,
-0.007045814,
0.0173537,
-0.012870002,
0.038088337,
-0.030349167,
0.021804383,
-0.0057251365,
-0.014593485,
-0.012453988,
-0.02591169,
-0.0037738357,
-0.01973092,
-0.029081317,
0.007930668,
0.00091704534,
-0.0048105675,
-0.005500621,
-0.019929022,
0.0135897705,
0.002499382,
-0.00011999592,
-0.013087913,
-0.021461008,
-0.008874952,
0.01518779,
-0.009462654,
-0.00035390028,
0.018291382,
0.022517549,
-0.0017069755,
-0.014527451,
-0.0014197282,
0.026162619,
0.0012975655,
0.0040676864,
-0.016534882,
0.0075476714,
-0.019744126,
0.012599262,
-0.010334301,
-0.005299218,
-0.016244331,
0.013642597,
0.012434178,
0.008353285,
0.026268274,
0.008432525,
0.0056591025,
0.019572439,
0.025726795,
0.007111848,
-0.0050020656,
-0.010717297,
0.0034304594,
-0.0029880325,
0.008386302,
-0.015214204,
-0.02624186,
0.024894768,
0.008386302,
-0.008458938,
-0.0011118453,
0.00538176,
-0.014263316,
0.017010326,
-0.00059471757,
0.010955019,
0.024670254,
0.013616184,
-0.016138678,
-0.006098228,
-0.021130838,
0.020061089,
0.0020602567,
-0.00276847,
-0.017036738,
0.000990508,
-0.00898721,
-0.015280237,
-0.035843186,
-0.010862571,
-0.027443675,
-0.008822125,
0.016917877,
-0.005814282,
0.0031101953,
0.027073886,
0.009310775,
-0.017432941,
-0.020787463,
-0.0043978556,
-0.025515487,
0.0019314907,
-0.010340904,
0.0026099887,
0.019598853,
0.009251345,
0.029160557,
0.021289319,
0.0077193594,
-0.0037606289,
0.0032290563,
-0.015016102,
0.00017096581,
-0.0029583173,
-0.0018027247,
-0.009918287,
0.031088745,
-0.005989272,
-0.015346271,
0.033016935,
-0.01674619,
0.004846886,
-0.029662414,
-0.007871238,
-0.01854231,
0.021210078,
-0.017895179,
-0.006250106,
-0.02103839,
0.021711936,
0.027073886,
-0.0057614553,
-0.0076467223,
-0.0041403235,
-0.012790761,
0.0004168388,
0.00941643,
0.0124870045,
0.029530346,
0.005956255,
0.0057053263,
0.018370623,
-0.043212563,
0.012183249,
-0.002575321,
0.0032075953,
0.0059265397,
-0.011437066,
0.011681392,
0.0026760225,
0.013933146,
-0.01846307,
0.02640034,
-0.0154123055,
-0.01347091,
0.004886506,
-0.037982684,
0.013186964,
0.020695014,
0.026994646,
0.00869666,
-0.0036912933,
-0.004312012,
-0.027417263,
-0.017076358,
0.05657782,
0.021381767,
-0.004193151,
0.0027932327,
0.007508051,
0.014950068,
-0.0042690895,
0.011417256,
-0.033756513,
-0.0049921605,
0.028975662,
0.00430871,
-0.00006923239,
-0.65378815,
-0.0014205537,
-0.01600661,
-0.014302936,
0.0031712765,
0.017710283,
0.029503932,
-0.00017075946,
0.0003303757,
0.030032204,
-0.0029104429,
0.012414368,
-0.027707811,
-0.030032204,
0.0064680176,
-0.022028899,
-0.015280237,
0.014633105,
0.006322743,
-0.013721838,
-0.03716386,
-0.0078580305,
0.001981016,
0.013523736,
-0.0004444905,
0.038220406,
0.007375983,
-0.014950068,
0.00006102974,
-0.0005889396,
0.00783822,
0.038458124,
0.00049401587,
0.00937681,
0.05182338,
-0.058109805,
-0.017076358,
0.03359803,
-0.0067684716,
0.028315322,
-0.017023532,
-0.004813869,
0.012216266,
0.002499382,
-0.0016549738,
0.022411896,
-0.0013099469,
-0.00014341732,
0.022979787,
-0.029873723,
0.0034799848,
-0.005629387,
0.013035086,
-0.0064482074,
0.00037680578,
-0.025436247,
0.008577799,
0.02148742,
-0.009000417,
0.0028312022,
0.0117606325,
0.020655394,
0.0050284793,
-0.019915815,
-0.023521265,
0.028183255,
-0.016178299,
0.022345861,
-0.0063722683,
-0.039488252,
0.008320267,
0.015570787,
0.0009839047,
0.0064383023,
0.034231957,
0.0022022296,
0.0054576993,
0.00087494875,
-0.01965168,
0.010241853,
0.012724726,
0.025357006,
0.007494844,
0.0041238153,
0.012407764,
-0.01887248,
-0.009673961,
0.014910447,
-0.020787463,
0.022821305,
0.03135288,
0.015650027,
0.007891048,
-0.0311944,
-0.018806446,
0.009106071,
-0.0061345464,
-0.012117215,
0.009680565,
-0.024934389,
-0.015808508,
-0.003113497,
0.021315733,
-0.0002065622,
0.031590603,
0.016719775,
-0.022372276,
-0.0017251348,
0.038775086,
-0.024128776,
-0.0010094928,
-0.00030272402,
0.014857621,
-0.005226581,
-0.0138274925,
-0.024855148,
0.0013619486,
0.0019215856,
0.0036153544,
-0.029028488,
0.008095752,
0.0048633944,
0.032911282,
-0.006217089,
-0.021091217,
0.004047876,
-0.0055237333,
-0.007250519,
-0.031801913,
0.000146719,
-0.011945527,
0.018000834,
0.022094933,
-0.013028483,
0.040307075,
0.004833679,
0.009634341,
-0.0064944313,
0.023745779,
-0.020325225,
-0.025277765,
0.005427984,
-0.014316143,
-0.014065214,
-0.023468437,
-0.02157987,
-0.007468431,
-0.00023875371,
-0.00021316558,
0.010208836,
-0.007012797,
-0.0012521673,
-0.02014033,
-0.011978544,
0.001335535,
-0.025370212,
-0.009588118,
-0.036688417,
-0.011945527,
0.020457292,
-0.0032521682,
-0.0007779615,
0.027338022,
-0.01320017,
0.0027156428,
-0.013352049,
-0.03209246,
0.021896832,
-0.010895588,
-0.022438308,
0.0002453571,
-0.018476278,
0.0031646732,
0.0049360315,
0.0075740847,
-0.00021564185,
-0.005484113,
-0.008894762,
-0.018304588,
-0.01608585,
0.026968231,
0.011384239,
-0.031801913,
0.026030552,
0.02665127,
0.020932736,
0.0010202233,
0.016891465,
-0.00004225136,
0.023428816,
-0.024551393,
0.009839047,
-0.00933719,
0.006761868,
0.0022699144,
-0.0118728895,
0.029054902,
-0.004493605,
0.008379698,
0.023560885,
0.024855148,
-0.03394141,
0.020404465,
0.006299631,
0.022623204,
0.016099058,
-0.0039257137,
-0.015980197,
0.036001667,
-0.003674785,
0.005764757,
-0.0040214625,
-0.009594721,
-0.0140388,
-0.03370369,
0.01310112,
0.028315322,
0.0056260857,
-0.019295096,
-0.018410243,
0.0077061527,
-0.016151885,
0.029134143,
0.009211725,
-0.019030962,
0.0118927,
-0.0046058623,
0.011430463,
0.021064805,
-0.003965334,
0.0036087509,
0.000049138485,
0.030085031,
0.013761458,
0.027971948,
0.007283536,
0.03164343,
0.0006104006,
0.021804383,
0.0021956263,
0.0016690061,
0.028500218,
0.033756513,
-0.031907566,
0.00072142005,
-0.028711526,
0.016680155,
-0.012434178,
-0.009231535,
0.008868349,
0.009152294,
0.009238139,
-0.0033330596,
-0.010189026,
-0.0070392103,
0.0049393335,
0.011905907,
0.003351219,
-0.0105390055,
0.040914584,
0.02051012,
0.027126713,
0.017155599,
-0.011674788,
-0.0056690075,
0.003499795,
-0.002218738,
0.010103182,
-0.012196456,
-0.021751557,
-0.024089156,
0.0009393318,
0.010770124,
0.006444906,
0.025990931,
0.014065214,
0.0029781274,
-0.01600661,
0.016838636,
0.0239835,
-0.007283536,
-0.016997118,
0.020681808,
0.023428816,
-0.006481224,
-0.014474624,
0.006507638,
-0.0019199348,
-0.011866286,
0.008505163,
-0.008485353,
0.0065010344,
-0.015768887,
0.00006959351,
-0.016561294,
0.018476278,
0.011410653,
-0.013933146,
0.018634759,
-0.012500212,
-0.009383413,
-0.011120103,
-0.0045827506,
-0.024947597,
0.03045482,
-0.0029797785,
-0.022398688,
-0.010380524,
0.023692952,
-0.0060354955,
0.006880729,
-0.0052761063,
0.0016458943,
0.02177797,
-0.009693772,
0.014025594,
-0.020932736,
-0.022398688,
0.021394974,
-0.0067585665,
-0.001212547,
-0.01883286,
-0.00984565,
-0.016640535,
0.052298825,
0.013193567,
-0.0026578633,
0.006689231,
-0.020021468,
0.0030193988,
-0.012183249,
-0.00452332,
0.013893526,
0.028526632,
0.002875775,
-0.024868356,
0.021685522,
-0.020338431,
0.0040346696,
0.017749904,
0.0011432114,
-0.030164272,
-0.017340494,
0.009977718,
-0.008174993,
-0.0035295102,
0.010756917,
0.047306664,
0.026796544,
0.008141976,
0.003070575,
0.017736698,
-0.0024036327,
-0.0110276565,
-0.0059727635,
0.00859761,
-0.0076004984,
0.018647965,
-0.0010557165,
0.00734957,
0.0023640126,
-0.004559639,
0.031669844,
-0.0013380112,
0.017881973,
0.020285605,
-0.008155183,
0.014619899,
0.00025691302,
-0.019268682,
-0.009964511,
0.025290972,
0.020074297,
-0.023534471,
0.04915561,
0.014461418,
-0.027971948,
-0.0044539846,
-0.020193158,
0.009568308,
-0.005094513,
-0.0019149822,
-0.0034931917,
-0.014197282,
-0.009773012,
-0.013814285,
0.01875362,
-0.00088567927,
0.0017581518,
-0.0023838228,
-0.016772604,
0.0066066887,
-0.014897241,
-0.0029880325,
-0.03721669,
-0.020615773,
-0.013814285,
0.016772604,
0.013840699,
0.022028899,
0.039144877,
-0.027258782,
-0.008373095,
0.008353285,
-0.02214776,
0.0005080481,
0.012288903,
-0.0054147774,
0.0056392923,
0.0089607965,
-0.008234424,
0.0043813474,
-0.000012187892,
-0.011384239,
0.0013330587,
-0.014685933,
0.011608754,
-0.013919939,
0.020496912,
-0.004037971,
0.022081725,
0.029715242,
0.016231125,
-0.0019083788,
0.0042624865,
-0.024987217,
0.020774255,
-0.023389196,
0.0028675208,
0.0052959165,
-0.023811813,
0.0052827094,
-0.0067684716,
-0.029900135,
0.0065307496,
0.009205122,
0.01977054,
0.00571193,
0.017010326,
0.013933146,
0.000888981,
0.018608345,
0.021078011,
-0.014025594,
-0.001982667,
-0.013787872,
0.046170883,
0.022543963,
-0.021672316,
0.02501363,
-0.0077589797,
-0.022240207,
-0.020708222,
0.028420977,
0.023323163,
-0.002961619,
-0.004318615,
-0.017683871,
-0.019546025,
-0.015121756,
-0.0024647142,
0.014950068,
0.009092864,
-0.01236154,
-0.0019133313,
0.015742475,
-0.012744537,
-0.02762857,
0.04442759,
-0.01518779,
-0.021830797,
-0.016627328,
-0.028711526,
0.019387543,
-0.016033024,
0.025951311,
-0.0041106082,
0.008940986,
-0.011886097,
0.000969047,
-0.020444086,
0.008749488,
0.016693363,
0.016917877,
0.014791586,
-0.0014964925,
0.014342557,
0.021711936,
-0.0070722275,
0.0061741667,
0.005437889,
0.0069599696,
-0.003661578,
0.0036912933,
0.020206364,
0.005213374,
-0.00017808509,
-0.026809752,
-0.002575321,
0.03370369,
-0.014474624,
0.008775901,
-0.011417256,
-0.024128776,
-0.00023772194,
-0.0081023555,
0.0034304594,
-0.006461414,
-0.041205134,
-0.027892707,
0.055521276,
0.0053586485,
0.00391911,
-0.0035063985,
0.00090879115,
-0.018291382,
0.000351424,
0.0025175412,
0.0037342154,
0.008901366,
-0.032277357,
-0.01867438,
0.010618246,
0.016178299,
-0.027602157,
-0.00010936859,
0.013484116,
-0.00027961217,
0.0020949244,
-0.0041502286,
-0.0008980606,
-0.0066066887,
0.0163764,
-0.019664885,
0.0005757328,
0.0051737535,
-0.0027404055,
-0.02754933,
-0.0017498975,
0.005216676,
-0.008023115,
0.033254657,
-0.03132647,
0.009739996,
0.021421388,
0.0027420565,
0.020483706,
0.0003547257,
0.050502703,
-0.011602151,
0.01916303,
-0.029081317,
-0.0024548091,
0.0135897705,
0.008980607,
0.027179541,
0.008122166,
-0.03631863,
0.0012645486,
0.01797442,
0.008630627,
-0.035763945,
-0.015253824,
0.015570787,
-0.007943874,
0.0068014883,
-0.009548497,
0.010017338,
-0.031854738,
0.042869188,
-0.029319039,
0.0059826686,
0.011311602,
-0.0029632698,
-0.015848128,
0.04817831,
-0.0031068935,
-0.015504752,
0.020536533,
0.0023029312,
-0.002552209,
-0.01023525,
-0.010776727,
0.0074156034,
0.0093239825,
0.026373928,
-0.0016764349,
0.009700376,
0.0017383416,
-0.009475861,
0.0002550558,
0.017842352,
-0.0043549337,
0.028183255,
0.010089975,
-0.004351632,
-0.00618077,
0.0019182839,
0.0023970294,
0.012097405,
-0.009165501,
-0.042420156,
-0.0033792832,
-0.0126719,
0.017155599,
0.008835332,
-0.023508057,
-0.0026859276,
-0.025515487,
-0.011800253,
-0.02873794,
-0.028420977,
0.014052007,
-0.030032204,
-0.012744537,
-0.011661582,
-0.00042880743,
0.025290972,
-0.003909205,
-0.02747009,
0.01103426,
0.032884866,
-0.0321717,
0.010136199,
-0.004688405,
-0.010023941,
-0.018397037,
0.017802732,
-0.02530418,
-0.0033231545,
0.013008673,
-0.00010488035,
-0.032779213,
-0.030190686,
-0.0011910859,
0.007283536,
-0.020642187,
-0.0078052036,
0.008485353,
0.01625754,
0.0074090003,
-0.031432122,
-0.014685933,
0.007732566,
0.009495671,
0.009390016,
0.020536533,
-0.012308713,
0.031432122,
0.0008023115,
0.019519612,
0.0075212577,
-0.011219154,
-0.0020288907,
-0.0034106493,
0.023706159,
0.0031976902,
0.00043541082,
-0.028156841,
-0.008729678,
-0.010968226,
0.015359478,
0.012803967,
-0.014263316,
-0.01616509,
0.0066430075,
-0.02152704,
-0.0013594723,
-0.0045068115,
0.013655804,
0.030639715,
0.009673961,
-0.017670663,
-0.018978134,
0.008822125,
0.043846488,
0.027205953,
-0.02665127,
-0.01981016,
-0.011172931,
-0.028764354,
-0.016508467,
-0.019823367,
0.039858043,
-0.0144350035,
0.009726789,
-0.0051968656,
0.011351222,
-0.011787046,
0.0118728895,
-0.04696329,
-0.025541902,
0.024907976,
0.013933146,
-0.004404459,
-0.01739332,
-0.028922835,
-0.011318205,
0.023243923,
0.0033941409,
-0.00816839,
0.018819652,
0.008141976,
0.009819237,
-0.018476278,
0.0115097035,
0.019915815,
0.005474208,
0.0025390023,
-0.04265788,
-0.0032571207,
-0.0041733407,
-0.024089156,
0.028843595,
-0.015478339,
0.0048832046,
-0.006444906,
0.00089971145,
-0.012110611,
-0.01682543,
0.00071399123,
-0.023574091,
0.020404465,
0.020272398,
-0.023732573,
0.023957089,
0.0286587,
-0.0047775507,
0.0013330587,
0.009053243,
-0.014646312,
0.015570787,
0.0076665324,
-0.034865882,
-0.006207184,
-0.0135897705,
0.020113917,
-0.023045821,
-0.011661582,
0.004222866,
-0.019638473,
-0.0110276565,
0.008980607,
0.0082212165,
0.0006322743,
0.0054345876,
0.007375983,
-0.0038860932,
0.0077853934,
-0.008690057,
-0.008194803,
0.0027057377,
-0.012249283,
-0.006702438,
-0.03594884,
0.019347923,
-0.00777879,
-0.010671074,
-0.015663235,
0.020153537,
0.1928189,
0.023323163,
-0.005923238,
0.0384053,
-0.010248456,
-0.008650437,
0.010855968,
-0.006193977,
0.0017994229,
0.026387135,
-0.0070260037,
0.01070409,
0.001702023,
0.0026694192,
0.02054974,
0.0077193594,
-0.037560064,
-0.013946353,
-0.009548497,
0.005728438,
-0.014567072,
0.0014469671,
-0.008881556,
-0.0027750733,
0.029107729,
0.0066958345,
0.014104835,
-0.009931494,
-0.00984565,
0.010261663,
0.015927369,
-0.01432935,
-0.0010012386,
0.009931494,
-0.0005014447,
-0.015729267,
0.03708462,
-0.023309955,
0.0009773013,
0.013292618,
0.0011630215,
0.028051188,
-0.024128776,
-0.018846067,
-0.016059438,
0.03478664,
-0.012870002,
-0.0032455646,
-0.03967315,
-0.004179944,
-0.022359068,
-0.0012067689,
0.015887748,
0.017129187,
0.0057152314,
-0.0032472156,
0.031854738,
0.010882381,
-0.0036978966,
0.027787052,
-0.01440859,
0.0051308316,
-0.017961213,
0.03962032,
-0.0056062755,
0.009654151,
-0.024260843,
-0.013008673,
-0.034575336,
0.0067948853,
-0.008122166,
-0.008234424,
-0.0038068525,
0.016468847,
-0.0022534057,
-0.013305825,
0.021434594,
0.026083378,
-0.008557989,
0.016640535,
-0.005748248,
-0.013774665,
-0.0022121347,
0.008980607,
-0.045589782,
-0.034813058,
-0.013867113,
0.02513249,
-0.0126058655,
-0.0059067295,
-0.006497733,
-0.035077192,
-0.0027800258,
-0.01678581,
-0.014633105,
0.022227,
-0.003167975,
-0.008247631,
0.0016797365,
-0.006926953,
-0.009726789,
0.02636072,
0.008115563,
0.005494018,
0.010446558,
-0.011318205,
-0.0117540285,
0.017168807,
-0.0015220807,
-0.031590603,
-0.0004894761,
-0.02403633,
0.007765583,
-0.002811392,
0.0033759815,
0.01809328,
0.0014618248,
-0.015821716,
0.0049030147,
-0.024511773,
-0.007983495,
-0.024128776,
0.003770534,
0.0046190694,
0.00054560485,
-0.036371455,
-0.02628148,
0.0066595157,
-0.0073363627,
-0.015095343,
0.00633595,
-0.014963275,
-0.0056591025,
0.0050912113,
0.007580688,
0.004146927,
-0.015755681,
-0.0111465175,
-0.012553039,
-0.0057680584,
-0.0006037972,
-0.026373928,
0.01395956,
0.009158898,
0.007422207,
-0.026056966,
-0.0017152297,
-0.003189436,
-0.005114323,
-0.017868765,
-0.03954108,
-0.035103604,
-0.0024201414,
-0.0056591025,
0.037956268,
-0.003423856,
-0.042261675,
-0.015768887,
-0.022227,
-0.0018340907,
-0.021276113,
0.016217919,
0.012077595,
0.0022583583,
-0.019083789,
0.020404465,
-0.16735624,
0.010558816,
0.023217509,
-0.02509287,
0.018555518,
-0.023283543,
0.019374337,
-0.006012384,
-0.02505325,
-0.0056624045,
0.037269518,
0.0150425155,
-0.0066331024,
0.003093687,
-0.011245568,
-0.0077986,
-0.0054676044,
0.008359888,
0.036952555,
0.0035955443,
0.028764354,
0.0069731767,
0.020642187,
-0.013259601,
-0.030824611,
-0.01555758,
-0.00939662,
0.01932151,
0.012269093,
-0.014725553,
-0.022306241,
0.011522911,
0.0066529126,
-0.013378462,
-0.013081309,
0.0030953377,
-0.009997528,
-0.01191251,
-0.000125258,
-0.007323156,
0.021434594,
0.0321717,
-0.004037971,
-0.009469257,
0.018529104,
0.01805366,
0.0015443672,
0.006217089,
0.0023144872,
-0.014091628,
0.021170458,
-0.021461008,
0.02587207,
-0.002801487,
0.009172104,
-0.007970288,
-0.0016458943,
0.0072439155,
0.024168396,
-0.024841942,
0.013695424,
-0.011285189,
0.020787463,
0.0054444927,
-0.015610407,
-0.02337599,
-0.023626918,
-0.02132894,
-0.024023121,
0.018119695,
-0.0068543158,
-0.03705821,
-0.0057812654,
0.0015815112,
0.021910038,
-0.005470906,
0.007442017,
-0.021130838,
-0.0017251348,
0.014976482,
-0.0071778814,
0.043133322,
-0.030877437,
0.018595139,
-0.0082278205,
0.019110203,
0.005447794,
0.011331412,
-0.024023121,
0.00044696676,
0.0010763521,
-0.027073886,
-0.035552636,
-0.0151745835,
0.018595139,
0.007679739,
0.021672316,
-0.011899304,
0.0057911705,
-0.018291382,
0.010321094,
-0.013153947,
-0.0138274925,
-0.0038860932,
0.048732996,
-0.0112719815,
0.009462654,
0.015570787,
0.029424692,
-0.0133388415,
-0.006527448,
-0.010565419,
0.007937271,
0.005124228,
-0.0046256725,
0.037903443,
0.0181329,
-0.04109948,
0.022477929,
0.016112264,
0.055732585,
0.004695008,
-0.03127364,
0.016680155,
0.028262496,
-0.028922835,
-0.116430916,
-0.014421797,
0.0013165503,
0.032937694,
0.022121346,
0.023085441,
-0.0115031,
0.026096586,
0.00083986827,
0.03370369,
0.0067684716,
-0.011905907,
-0.0008229471,
-0.0067387563,
0.01399918,
-0.012229472,
0.017842352,
-0.014118041,
-0.048680168,
0.03066613,
-0.000910442,
-0.0019479991,
-0.0126124695,
-0.003889395,
-0.00657037,
-0.014078421,
-0.042393744,
0.04720101,
0.015491546,
0.010558816,
0.020245984,
-0.011238964,
0.009284362,
-0.007045814,
0.0011762283,
-0.010605039,
-0.018608345,
-0.019334717,
0.019876195,
-0.015531166,
-0.002045399,
0.017868765,
0.024855148,
-0.000008267131,
-0.0021461009,
-0.008095752,
-0.017749904,
-0.011120103,
-0.021645902,
-0.01625754,
-0.0031960392,
-0.0031514664,
-0.012434178,
0.008690057,
-0.010340904,
-0.036662005,
0.03819399,
-0.0027305004,
-0.004199754,
0.0034601747,
0.0012315316,
0.010426748,
-0.02021957,
0.019717714,
0.016799016,
-0.02386464,
-0.027602157,
0.009693772,
0.0052595977,
-0.008141976,
0.01920265,
0.012249283,
0.0006042099,
0.013761458,
-0.01875362,
0.013305825,
-0.036635593,
-0.0033033444,
-0.0023854736,
-0.0034502696,
-0.025211731,
-0.022570377,
0.00030127954,
0.0031465138,
-0.017987626,
0.003694595,
0.0018126298,
-0.016112264,
0.0067057395,
-0.014910447,
0.009277759,
0.028685113,
0.028104015,
-0.0337301,
-0.031775497,
0.0063854754,
0.0034403645,
-0.0060553057,
-0.0093239825,
-0.0118794935,
-0.026347514,
-0.009218329,
-0.049868777,
0.018317796,
0.03623939,
-0.01142386,
-0.019400751,
-0.0066859294,
0.019070582,
0.009119278,
0.0022121347,
0.0039917473,
-0.0046487846,
0.0037969474,
-0.029028488,
-0.0012389604,
-0.008141976,
-0.017551802,
0.01019563,
0.007970288,
0.029160557,
0.0021807686,
0.007963684,
0.027813466,
0.012335127,
0.016231125,
-0.0077061527,
-0.0068543158,
-0.013385066,
0.02214776,
-0.0037276119,
-0.015214204,
-0.0018984737,
-0.025938105,
-0.0073165526,
-0.0018472975,
-0.02132894,
-0.010922002,
-0.0049030147,
0.023838228,
-0.0026743717,
0.005632689,
0.00017075946,
-0.01936113,
-0.009964511,
-0.012658693,
0.0011019402,
0.008789108,
0.0035922425,
0.008736281,
-0.019625265,
0.011106897,
0.021566661,
-0.0029880325,
0.003308297,
-0.039567493,
-0.003318202,
0.007151468,
-0.007395793,
-0.008267441,
0.0011101945,
-0.025489073,
0.037718546,
-0.012889812,
0.019070582,
-0.0016112265,
0.014910447,
-0.016983911,
0.0068212985,
0.0029104429,
0.011397446,
-0.023389196,
-0.012097405,
-0.011344619,
0.029134143,
-0.005870411,
-0.001497318,
0.004080893,
0.005675611,
0.031458534,
0.01805366,
0.03631863,
0.008075942,
-0.005949652,
-0.04310691,
0.02513249,
0.015451926,
0.016534882,
-0.023111854,
0.023481645,
-0.020642187,
-0.008307061,
-0.0076467223,
0.007983495,
-0.0039059033,
-0.03336031,
0.015095343,
0.018264968,
0.011437066,
-0.010690884,
0.016349986,
0.021593075,
-0.0031167986,
-0.0016450688,
-0.014765173,
-0.031590603,
-0.0122426795,
-0.012625676,
0.0021444499,
-0.016838636,
-0.041654166,
0.023389196,
0.008868349,
0.032435838,
-0.009456051,
0.010228646,
-0.00026331007,
0.0077721863,
-0.026796544,
0.000009150592,
-0.010770124,
0.004866696,
0.0064878277,
0.014989688,
0.018568724,
-0.0073099495,
-0.004331822,
0.024089156,
0.02206852,
-0.009158898,
0.0073165526,
-0.004586052,
0.010023941,
0.00006133928,
-0.023877848,
-0.018951721,
-0.005005367,
-0.0025043346,
0.021064805,
0.0076929457,
-0.0054576993,
0.06819978,
0.022253415,
0.0005687167,
-0.012057785,
0.016217919,
0.035763945,
0.017512182,
0.0056954212,
-0.0327528,
-0.03148495,
0.0043054083,
-0.020113917,
0.012764347,
-0.02836815,
-0.028473804,
0.029900135,
0.016719775,
0.020747842,
0.020628981,
-0.016561294,
0.0110276565,
-0.04178623,
0.023851434,
0.0040544798,
-0.007917461,
-0.015451926,
0.020655394,
0.015953783,
-0.005262899,
-0.016138678,
0.016772604,
0.013002069,
-0.030877437,
-0.0071910885,
0.0028080903,
-0.035182845,
-0.0013132485,
0.0045926557,
0.0050548925,
0.0135897705,
0.011582341,
-0.02039126,
-0.030428408,
-0.00573174,
-0.0368469,
-0.023930674,
-0.0074156034,
-0.014936862,
-0.015914163
] |
Post-translational modifications of Notch3 and their functional role with respect to Notch3 overexpression in T-cell leukemia are still poorly understood. We identify here a specific novel property of Notch3 that is acetylated and deacetylated at lysines 1692 and 1731 by p300 and HDAC1, respectively, a balance impaired by HDAC inhibitors (HDACi) that favor hyperacetylation. By using HDACi and a non-acetylatable Notch3 mutant carrying K/R1692−1731 mutations in the intracellular domain, we show that Notch3 acety | [
-0.021996502,
0.0030211862,
0.021969838,
-0.027595611,
-0.025209323,
0.03407458,
-0.02967528,
0.017463889,
-0.017717183,
0.01594413,
0.034154568,
-0.006638944,
0.019756857,
0.0014822643,
0.003776066,
-0.008905251,
0.020383425,
-0.01374448,
-0.0052824933,
-0.0159308,
-0.044686224,
0.028315496,
-0.008185364,
-0.020969998,
-0.0090318965,
0.019623546,
0.013471191,
-0.026702419,
0.00017820082,
-0.000595322,
0.016090773,
0.025102673,
0.0025146,
-0.0062723355,
-0.011138229,
0.0024046176,
-0.0052524977,
-0.034901116,
0.017543877,
0.0054924595,
0.019916832,
0.016250748,
-0.015410882,
0.0013822801,
0.0047525773,
0.009411836,
-0.006149022,
0.0012672985,
-0.0039493716,
0.024609419,
-0.0012897948,
0.010011741,
-0.003522773,
0.010185047,
-0.031514987,
-0.016464047,
0.010111725,
0.035887625,
-0.009865098,
-0.01483764,
0.021863189,
-0.028608782,
-0.015984124,
0.011538165,
-0.010884935,
0.042579893,
-0.0022996343,
-0.008718614,
0.00867862,
0.014824308,
0.03714076,
0.011658146,
-0.016997296,
-0.0019163619,
0.008605298,
-0.0052058385,
-0.0040560216,
-0.014264397,
-0.014344385,
0.01714394,
0.023062998,
-0.022249794,
-0.009838435,
0.033541333,
0.021316608,
-0.004822566,
0.0034927777,
0.019530227,
0.008112043,
0.01043834,
0.009025231,
0.0053024897,
0.034341205,
0.016424054,
-0.040286925,
0.006552291,
0.0011764795,
0.01682399,
0.009685126,
-0.02254308,
-0.034794465,
0.0016072444,
-0.004169337,
-0.011584824,
-0.022129813,
-0.024929369,
0.0029578628,
0.014024436,
0.013284554,
0.012078078,
-0.009338515,
0.027075693,
-0.0142244045,
-0.026075853,
0.03628756,
-0.039780337,
0.013557844,
0.011064907,
-0.00027933056,
-0.0049258834,
0.023982853,
0.044446263,
0.006652275,
-0.033461343,
0.013171238,
0.012724643,
0.0159308,
0.0004168087,
-0.01462434,
0.00697889,
0.022676393,
0.009205203,
-0.004645928,
-0.006752259,
-0.021449922,
0.011891441,
-0.0006294832,
0.008478652,
0.0023129655,
-0.03266147,
-0.004016028,
0.016570698,
-0.0103050275,
-0.010551655,
0.008278683,
0.0045426106,
0.012584665,
0.0050058705,
-0.0061390237,
0.0053624804,
0.001929693,
0.009311852,
0.03575431,
-0.01071163,
-0.018823672,
0.028048871,
-0.016970634,
0.0056091077,
-0.022343112,
-0.01790382,
-0.014144417,
0.003912711,
0.028875407,
0.034794465,
0.04098015,
0.016677348,
0.007532135,
0.0057090917,
-0.023036337,
0.0076054567,
0.012004757,
0.019183615,
-0.0041860007,
0.008605298,
-0.021796534,
-0.016610691,
0.01945024,
0.010651639,
-0.037514035,
-0.023396278,
-0.009298521,
0.021316608,
0.025689248,
0.02143659,
-0.027728923,
0.0036160916,
0.0062590046,
-0.020143462,
0.0006240674,
-0.018637035,
0.0067955856,
0.01770385,
-0.009591808,
-0.020916672,
-0.6160087,
-0.012917945,
0.013704487,
-0.004772574,
0.010431674,
0.052818265,
0.021623228,
-0.0032178215,
-0.03295476,
0.01934359,
-0.011124897,
0.015784156,
0.01049833,
-0.028208846,
-0.030421827,
-0.038393892,
0.0009948418,
-0.02208982,
0.0224231,
-0.0017880489,
-0.024716068,
-0.0073588295,
-0.017197264,
0.014677665,
0.0014531022,
0.020276776,
0.05175177,
-0.0010723295,
-0.03362132,
0.0129512735,
-0.021729877,
0.0058823978,
-0.012931276,
0.0017930481,
0.045246135,
-0.002709569,
0.0045659402,
0.009151878,
0.011611487,
0.023462934,
0.010864939,
-0.005339151,
0.03924709,
0.022823036,
-0.02274305,
0.0041093463,
-0.006612282,
0.0015214246,
-0.01737057,
-0.02738231,
0.007345498,
-0.011744798,
-0.027995547,
0.008485317,
0.01160482,
-0.009751782,
0.01801047,
-0.017023958,
0.01626408,
0.014690996,
0.0054424675,
0.014357716,
-0.01747722,
-0.015357557,
-0.022103151,
0.012071413,
0.0027578946,
0.002008014,
0.013597837,
0.014384379,
0.0019513563,
0.024596088,
-0.0073388326,
0.008991903,
-0.009611804,
0.028742095,
-0.00019715614,
-0.0029928572,
0.007225517,
0.0031128381,
-0.007012218,
-0.015784156,
-0.018890329,
0.010298362,
0.01923694,
0.02868877,
-0.00678892,
0.042259946,
0.0039893654,
-0.005555783,
0.002712902,
0.012171397,
-0.0030478486,
-0.020850018,
-0.018730354,
0.018557047,
0.00078445853,
0.023369616,
0.0055124564,
-0.02868877,
-0.026515782,
-0.013011264,
0.0023379615,
-0.015597519,
0.0076121227,
-0.0018097122,
-0.028262172,
-0.016970634,
0.028982056,
-0.03439453,
0.0047292477,
-0.0052958243,
-0.009525152,
-0.017770506,
-0.0007940404,
-0.025036018,
0.008172033,
0.010511661,
-0.0027312322,
-0.039727014,
0.0076121227,
0.008758606,
0.0075987913,
-0.012717977,
0.020356761,
0.018730354,
0.006049038,
0.0133378785,
0.0017022293,
0.00127813,
0.004675923,
0.0008436158,
0.026009196,
-0.025449285,
0.031834938,
0.00022663061,
0.029941903,
0.0019330259,
0.014277729,
-0.031381674,
-0.024862712,
0.0013489521,
0.0072588455,
0.0037294067,
-0.019743526,
-0.019610215,
-0.01581082,
-0.018730354,
0.018090457,
0.0013589505,
0.0033627984,
-0.0025329303,
-0.032261536,
-0.0022563078,
0.013591171,
-0.012871286,
0.0056857625,
-0.011411518,
-0.01605078,
-0.034447853,
-0.001148984,
0.019810183,
-0.02298301,
0.0069922213,
-0.004435961,
-0.021503245,
0.005062528,
0.005652434,
-0.019596882,
-0.013691155,
-0.0047659087,
-0.0033261376,
-0.031275027,
-0.017877156,
0.00006712474,
0.012351369,
-0.0044126315,
-0.016757334,
-0.0069188992,
0.0007244681,
0.017103946,
-0.023796216,
0.0014830974,
-0.015184252,
0.034767803,
0.014597678,
0.029755266,
0.01603745,
0.0010589982,
0.037300732,
-0.000639065,
-0.0004093099,
-0.03298142,
0.014637671,
-0.002174654,
-0.036927458,
0.036847472,
0.012131404,
-0.009958416,
0.03658085,
-0.006552291,
0.011838117,
0.006925565,
-0.027435636,
0.020516736,
-0.014384379,
-0.0075454665,
-0.025702579,
-0.012038086,
-0.01213807,
-0.011558161,
0.020476744,
-0.017277252,
0.0050358656,
-0.010278365,
0.0014989283,
-0.010751623,
-0.016237417,
-0.0073255016,
-0.035301052,
0.015664175,
-0.023782883,
0.016437385,
0.0053258194,
0.008218693,
-0.015250907,
0.010764955,
0.010038403,
-0.0031295023,
-0.022623068,
-0.037087433,
0.009791776,
-0.0020446747,
0.012584665,
0.023036337,
0.012518009,
0.020276776,
-0.015050939,
0.0349811,
-0.010351687,
0.0073788264,
0.00475591,
-0.0012223056,
-0.0088319285,
-0.01494429,
-0.021289947,
0.029168693,
0.027195673,
-0.0092318645,
-0.011618152,
0.0056590997,
0.040580213,
-0.008911916,
-0.004929216,
0.026515782,
-0.017010627,
-0.0031878264,
0.023049667,
0.04681922,
0.015690837,
-0.0029428652,
-0.00016289076,
0.010784951,
0.0054091397,
0.0065122973,
0.02506268,
-0.017397232,
-0.015637513,
0.0071122022,
-0.016210755,
-0.033061408,
-0.00668227,
0.008551973,
-0.029861916,
-0.01694397,
0.00036869134,
0.024089502,
-0.008538642,
0.018650366,
0.011751465,
-0.00060657016,
-0.025569266,
0.049405474,
0.023249635,
-0.022929685,
-0.0015697504,
-0.024022846,
-0.014664334,
-0.012044751,
0.011371525,
-0.0046159322,
0.020810023,
0.0090119,
0.00019892669,
-0.014357716,
-0.024609419,
0.0043959673,
-0.021823196,
-0.0070055523,
-0.003932708,
0.0026729081,
-0.01033169,
-0.015584188,
0.009671795,
0.0120647475,
0.005995713,
-0.019730195,
-0.018597042,
-0.027782248,
-0.005049197,
0.02252975,
-0.0070522116,
0.0049058865,
-0.017730514,
-0.0037294067,
0.0064489744,
0.0065256287,
0.012831292,
0.015624181,
0.006585619,
-0.031275027,
-0.015024276,
-0.033781294,
-0.010724961,
0.018290425,
0.016610691,
-0.010065066,
0.030101879,
0.0013156241,
0.0059023947,
-0.020570062,
0.0013106249,
0.025889216,
-0.004455958,
-0.0041093463,
0.012704646,
0.0015122595,
0.0102916965,
0.00023142152,
0.027222337,
-0.002244643,
-0.013504518,
-0.01231804,
-0.008771938,
0.010644973,
0.0014347718,
0.035007764,
0.019170284,
0.027648935,
0.0041260105,
0.00731217,
0.018890329,
0.01071163,
-0.0020280108,
0.021969838,
-0.018410405,
0.0090119,
0.0077987597,
-0.0008427826,
-0.01825043,
-0.0023712895,
0.016370729,
0.009571811,
0.0020013484,
0.009411836,
0.0059390552,
0.012717977,
0.0027645603,
-0.046792556,
-0.0017797169,
0.013377872,
0.015544194,
-0.02351626,
-0.032154884,
0.024036177,
-0.026302483,
-0.013651162,
0.019050304,
0.0054991255,
0.004725915,
0.0038160598,
-0.0222098,
0.008451989,
-0.030608464,
-0.005862401,
-0.01647738,
0.003859386,
-0.005535786,
-0.0008956909,
-0.023582915,
0.0062223435,
-0.018823672,
-0.033488005,
-0.009745116,
0.02748896,
-0.0018913659,
-0.026089184,
-0.013017929,
0.027209006,
0.018703692,
0.014850971,
-0.020636717,
-0.0043259785,
0.03295476,
-0.016224086,
-0.010538324,
-0.01605078,
-0.016797328,
0.018303756,
-0.005215837,
0.012624659,
-0.033008084,
-0.00022913022,
0.015024276,
0.019370252,
-0.004269321,
-0.0029611955,
0.0033644647,
-0.015117595,
0.0054824613,
0.022796374,
0.014770984,
0.006662274,
0.0005436635,
0.006069035,
0.005892396,
-0.0079654,
-0.043193128,
-0.017983805,
-0.030981738,
0.0006778088,
0.021383265,
-0.01374448,
0.007832088,
0.02583589,
0.011738133,
0.000007290507,
-0.0031195038,
0.016117437,
0.030741777,
0.0053124884,
0.024849381,
0.0066689393,
-0.013144576,
-0.012438022,
-0.012524675,
0.031248363,
-0.01121155,
-0.016250748,
0.027728923,
0.009378509,
-0.018397074,
-0.008185364,
0.0061390237,
-0.010451671,
0.011498171,
-0.01582415,
-0.008038721,
-0.027435636,
-0.027568948,
0.0042959834,
0.0022746383,
-0.0024246143,
-0.010311693,
-0.0086319605,
0.0175972,
-0.018263761,
-0.017863825,
-0.0033994592,
-0.03524773,
-0.016184092,
0.020263443,
0.010125056,
0.002974527,
-0.014557685,
-0.014704328,
-0.015197583,
-0.025569266,
-0.020410087,
-0.03162164,
0.0015672507,
0.008265352,
0.029701943,
0.04564607,
0.043913014,
-0.0072721764,
0.018530386,
0.00055074575,
-0.00017070201,
-0.0013497852,
-0.019370252,
0.019836845,
-0.0175972,
0.026329145,
0.012791298,
-0.012631324,
0.028742095,
-0.0115781585,
0.027075693,
0.028395483,
0.007185524,
-0.023822878,
0.0038193925,
-0.03914044,
-0.024262808,
0.024062838,
-0.014824308,
-0.0036394212,
-0.03220821,
-0.013931117,
0.026662426,
0.016104106,
0.00846532,
-0.0069322307,
0.0045159482,
-0.013771143,
0.034767803,
-0.0062090126,
-0.016397392,
0.003916044,
-0.0022079821,
0.013177904,
0.018290425,
0.010451671,
0.00088485924,
0.024929369,
0.0028845412,
-0.028928732,
0.007618788,
0.020090139,
-0.026742414,
0.006045705,
-0.0040560216,
-0.026195833,
-0.029755266,
-0.022796374,
0.0027229001,
-0.042606555,
0.012784633,
0.012597996,
-0.024676075,
-0.009078556,
-0.001418941,
0.010851608,
0.0068855714,
-0.003896047,
0.02911537,
-0.022396438,
0.009565145,
0.016677348,
0.0100917285,
-0.038713843,
-0.02911537,
-0.02055673,
0.0175972,
0.033781294,
0.024156157,
-0.011204884,
0.015757494,
-0.0020763364,
0.007185524,
-0.021129973,
-0.0245161,
-0.01011839,
-0.03012854,
0.00823869,
-0.019730195,
-0.00934518,
-0.010185047,
0.013197901,
0.019703534,
-0.002481272,
0.002439612,
-0.003656085,
-0.023529591,
0.021916514,
0.0070855394,
0.022916354,
0.023356285,
0.019770188,
0.0034327873,
-0.031115051,
-0.008785269,
0.014357716,
-0.006502299,
0.03671416,
0.007185524,
-0.008751941,
0.020850018,
0.003826058,
-0.0024996025,
-0.0040560216,
-0.0037860645,
0.04385969,
-0.004455958,
-0.003294476,
0.034127906,
-0.003756069,
0.024476107,
0.008745275,
0.0067255967,
-0.018037131,
-0.039167102,
0.012398028,
0.042953167,
0.0010914931,
-0.016224086,
0.0028395483,
-0.01291128,
-0.0042359927,
-0.021836527,
-0.042686544,
-0.0035427697,
-0.040606875,
-0.015544194,
-0.004079351,
0.010758289,
0.015530863,
-0.0066256127,
-0.022343112,
0.015890805,
0.020156793,
-0.026395801,
0.00089735724,
0.017890487,
-0.0010914931,
-0.013451193,
0.008625295,
-0.013264556,
0.00025391794,
0.011531499,
-0.0312217,
-0.03372797,
-0.008185364,
0.011084903,
0.030421827,
0.014011105,
-0.010318358,
-0.0030728446,
0.009471826,
0.018477062,
-0.02738231,
-0.014970952,
0.016730672,
-0.014064429,
-0.006229009,
0.017263921,
0.0023446272,
0.008905251,
-0.0051525137,
-0.027622273,
0.014717659,
-0.01671734,
-0.009238531,
0.0049025537,
-0.006945562,
-0.01878368,
0.0016622356,
0.006298998,
-0.03650086,
-0.026582438,
-0.0070722084,
-0.0030278517,
0.00580241,
-0.013197901,
0.005675764,
-0.011171556,
-0.016317405,
-0.00714553,
-0.012251385,
0.0025379297,
-0.043886352,
-0.039753675,
0.010484999,
-0.019530227,
0.023289628,
0.020476744,
-0.010211709,
-0.020356761,
0.0014531022,
-0.058070764,
-0.004229327,
-0.015504201,
0.007472145,
0.015224245,
0.011771461,
-0.010325024,
-0.014064429,
-0.016330736,
0.018197106,
-0.008778604,
-0.021183297,
0.009551814,
-0.014211073,
0.014571016,
0.0067255967,
-0.023356285,
0.005189175,
0.024969362,
0.010738292,
0.006422312,
0.014797647,
-0.02152991,
-0.000979011,
-0.035381038,
0.0069722245,
-0.010678302,
0.027462298,
0.01790382,
-0.02802221,
0.022116482,
0.0074454825,
0.0005465797,
-0.025102673,
0.01857038,
0.020570062,
0.005239167,
0.002422948,
0.0048892223,
-0.030795101,
-0.01043834,
-0.0072055208,
0.013564509,
0.016290743,
-0.012298044,
0.012231388,
0.01538422,
-0.013257891,
0.011331531,
0.01506427,
-0.003952705,
0.011744798,
0.0074788104,
-0.0030278517,
0.01801047,
0.0044459593,
-0.012884617,
-0.018543717,
-0.0201168,
-0.012178062,
-0.0004320146,
-0.03946039,
-0.0119780945,
-0.0031061727,
-0.036074262,
0.00907189,
0.012424691,
-0.011944767,
-0.003004522,
-0.01627741,
0.0018063793,
-0.008105378,
-0.0022913022,
-0.004972542,
0.00014383129,
-0.019356921,
0.022116482,
-0.038500544,
-0.0022313118,
0.015530863,
0.19388916,
-0.014184411,
-0.015237576,
-0.0023129655,
0.030528478,
-0.0041893334,
0.006095697,
0.01439771,
-0.02286303,
-0.0013331213,
0.03991365,
0.012797965,
-0.007472145,
-0.002979526,
0.017797168,
-0.005032533,
-0.02572924,
-0.0037027444,
-0.0360476,
-0.0033011416,
0.001838041,
-0.0073055048,
0.008898584,
-0.0015180919,
0.039860327,
-0.0067855874,
-0.02363624,
0.016557366,
0.013277888,
0.0033094736,
-0.032714795,
0.0030178532,
0.0063623213,
-0.009778445,
-0.013664493,
0.004982541,
-0.003756069,
0.000037598187,
0.008958575,
0.00521917,
0.010198378,
-0.011164891,
-0.01033169,
-0.011398187,
0.009651798,
-0.003896047,
0.003916044,
-0.0037827317,
-0.012464684,
0.00645564,
-0.024209483,
0.0035094419,
0.027075693,
0.021863189,
0.010951592,
0.009298521,
0.0004163921,
0.0090185655,
-0.009938419,
0.03748737,
-0.019983487,
0.0070855394,
-0.013484522,
-0.008198696,
-0.011198219,
0.021236623,
-0.015677506,
-0.0054491335,
0.018503724,
-0.022516418,
0.016450716,
-0.01801047,
-0.01049833,
-0.008805266,
0.0026862393,
-0.013491187,
0.07070875,
0.015544194,
0.017130608,
0.01923694,
0.025209323,
-0.0123646995,
-0.027622273,
0.0005903228,
-0.003979367,
-0.023316292,
0.02847547,
-0.01083161,
-0.015917469,
-0.014077761,
0.0091318805,
-0.0040260265,
-0.019423578,
0.0060823658,
-0.0020480077,
-0.008058718,
0.017677188,
0.0061923484,
0.003099507,
-0.010751623,
-0.0131512415,
0.07406822,
-0.024102833,
0.033488005,
-0.023342954,
-0.0069922213,
0.0054824613,
0.016144099,
-0.0051358496,
-0.016330736,
0.01923694,
-0.043939676,
0.011098235,
-0.015517532,
0.0101917125,
0.031914923,
-0.0017747177,
-0.016330736,
0.038073942,
-0.0132378945,
0.008871922,
-0.01083161,
-0.00557578,
0.033248045,
-0.010871604,
-0.004685921,
-0.028342158,
0.0048892223,
-0.010851608,
-0.030715114,
0.014744322,
-0.0020546732,
0.016464047,
0.012131404,
-0.0010148386,
-0.025369298,
-0.007705441,
-0.015397551,
0.0020930003,
0.037167422,
-0.011371525,
0.003759402,
-0.008691951,
0.016224086,
-0.017437227,
-0.014717659,
0.014690996,
-0.009758448,
-0.021036655,
-0.016730672,
-0.015077602,
-0.015490869,
-0.013117913,
-0.0075454665,
0.023662902,
-0.01837041,
0.002439612,
-0.021023322,
-0.032581486,
0.03791397,
-0.026022527,
0.012411359,
0.026342476,
-0.02340961,
-0.010311693,
-0.01336454,
-0.16680014,
0.0051058545,
0.0035461027,
-0.018490393,
0.03679415,
0.0446329,
0.045432772,
-0.020783361,
-0.0008219526,
0.013111248,
0.008332008,
0.009978413,
-0.022156475,
-0.043726377,
0.009045228,
0.022289788,
-0.01198476,
0.045886036,
0.0010831611,
0.01473099,
0.013397869,
-0.016437385,
0.027542286,
-0.020730035,
-0.00247294,
0.020690043,
-0.0014531022,
-0.025129337,
-0.0024462775,
0.010385015,
-0.017543877,
0.0026695754,
0.025622591,
0.025675915,
0.035594337,
0.0031861598,
-0.0059190583,
0.0010723295,
-0.003966036,
0.01615743,
0.018317087,
0.018663699,
0.007245514,
-0.002876209,
-0.030688452,
0.037460707,
0.022156475,
0.014051098,
0.022556413,
-0.011244878,
0.0013831133,
-0.01269798,
0.017543877,
0.015544194,
0.014770984,
0.014344385,
0.0014672666,
0.015704168,
-0.00808538,
-0.01725059,
-0.009945084,
0.0015439211,
0.03298142,
-0.0040893494,
-0.0064123133,
-0.032128222,
0.009431833,
-0.012737974,
-0.03495444,
0.014077761,
-0.0074254856,
-0.015050939,
-0.012244719,
-0.021476584,
-0.0037727333,
0.021703215,
-0.007078874,
0.009125215,
0.015584188,
0.013771143,
-0.014051098,
0.014144417,
-0.030875089,
-0.02780891,
-0.020090139,
-0.010125056,
0.0013222897,
0.0071122022,
0.0012173064,
0.00023017172,
0.011724802,
-0.024222814,
0.025076011,
-0.014917627,
0.025489278,
0.02504935,
-0.020796692,
-0.01286462,
-0.024809387,
-0.009378509,
0.0249427,
-0.032821447,
-0.0016089107,
0.011118231,
0.016570698,
0.01999682,
-0.027182342,
0.022063157,
0.046046007,
-0.027942222,
-0.0021929846,
-0.001838041,
0.019730195,
0.0009215201,
-0.0011431515,
0.021276616,
-0.00999841,
0.0114781745,
-0.008651957,
-0.013417866,
0.07822756,
0.006958893,
-0.0152109135,
-0.0013714485,
-0.007045546,
-0.01605078,
-0.13288553,
-0.02738231,
0.0006040706,
0.028742095,
-0.0025995865,
0.015850812,
0.016237417,
0.00802539,
-0.01946357,
0.02659577,
-0.024329463,
0.011304868,
0.0053224866,
-0.016570698,
0.000060302908,
0.013497853,
0.027249,
-0.013984443,
0.0010240038,
0.05012536,
-0.0024712735,
-0.0025479281,
0.011018247,
-0.015304232,
0.01681066,
0.011971429,
-0.037860643,
0.013271223,
0.0087986,
0.013104582,
-0.0048192334,
-0.0131379105,
0.025302641,
0.005265829,
-0.029488644,
-0.015904136,
0.024222814,
-0.021023322,
0.041273434,
-0.023782883,
-0.00055366196,
0.016557366,
-0.012977935,
-0.012824627,
-0.0027112353,
-0.0073255016,
-0.004082684,
0.025475947,
0.022903023,
0.000107066306,
-0.04034025,
-0.013797806,
-0.019090297,
-0.016664015,
0.041193448,
-0.014770984,
0.014384379,
0.030181866,
-0.034927778,
-0.02243643,
-0.0038660518,
0.0021846525,
-0.008138705,
-0.0020230114,
0.048525617,
-0.0017247257,
-0.01725059,
-0.024582757,
0.03231486,
-0.0043926346,
-0.004049356,
0.021703215,
-0.021516578,
0.022343112,
-0.0134112,
0.0043826364,
-0.016237417,
-0.024156157,
0.0018180441,
-0.0013706153,
-0.020596724,
-0.01253134,
0.02911537,
-0.0044592908,
0.017717183,
-0.0051758434,
0.0027845572,
0.0016589029,
0.0057457527,
-0.013384538,
-0.004825899,
0.041486733,
-0.0042759865,
-0.0054424675,
-0.016010787,
0.009591808,
0.01318457,
-0.0029861918,
0.007412154,
0.03132835,
-0.017530546,
-0.021823196,
-0.053724788,
0.01658403,
-0.01247135,
0.00015164254,
0.018197106,
-0.008998569,
-0.015104264,
-0.0056657656,
-0.0034994434,
0.00295453,
-0.003726074,
-0.003979367,
-0.018157111,
0.00018830338,
-0.023156317,
0.0054924595,
0.045806047,
-0.012051417,
0.012737974,
0.030341841,
0.0043659722,
-0.03471448,
-0.005415805,
0.012498012,
0.0041393414,
-0.024796056,
-0.008352005,
0.009705123,
0.0048558945,
-0.013477856,
0.007012218,
-0.037007447,
0.0036527524,
0.022156475,
-0.019423578,
-0.020583393,
-0.030688452,
0.024582757,
0.019116959,
0.012504677,
-0.008558638,
-0.048738915,
0.0056491015,
0.013511185,
-0.00016643186,
0.013611169,
-0.031941585,
-0.012737974,
-0.008365336,
-0.014597678,
0.036340885,
0.02858212,
-0.0040226933,
0.0004195166,
-0.015557526,
0.0020063475,
-0.001253134,
-0.0054991255,
-0.017463889,
-0.014264397,
-0.0013206233,
0.019503564,
0.017010627,
-0.0028545458,
0.005602442,
-0.0014472698,
-0.019756857,
-0.020930003,
-0.0029528637,
-0.005329152,
-0.0056324373,
-0.0016114104,
0.004625931,
-0.005419138,
0.011204884,
0.012398028,
-0.019103628,
-0.0019813515,
-0.014930958,
0.017997138,
0.021316608,
-0.027542286,
-0.035221063,
0.00074363174,
0.015304232,
-0.024542762,
-0.01659736,
0.012511344,
-0.0002947448,
-0.0025179328,
0.006958893,
0.02847547,
-0.00042555731,
0.008751941,
0.0010981587,
0.0072788424,
-0.0016405723,
0.005539119,
-0.013544512,
0.04143341,
-0.013631165,
-0.004385969,
-0.0040960154,
-0.015624181,
-0.0047659087,
0.03439453,
-0.023662902,
-0.055777796,
0.01148484,
0.004202665,
0.026942382,
-0.009971747,
-0.0038827157,
0.0038727173,
-0.003232819,
-0.00035452694,
0.0022896358,
-0.011224881,
-0.01527757,
0.03364798,
0.0015330894,
-0.016224086,
0.008198696,
0.0013472857,
0.017117277,
-0.019090297,
0.040073626,
-0.02274305,
0.017890487,
-0.012298044,
0.005949054,
0.007532135,
-0.023756221,
-0.0222098,
-0.014571016,
-0.018037131,
-0.004825899,
0.022996342,
0.0029411989,
0.105263256,
0.00829868,
-0.0037727333,
-0.016890647,
-0.026529113,
0.039193764,
0.024009515,
0.00074946415,
-0.0065989504,
-0.013177904,
0.023023004,
-0.016997296,
0.0228497,
-0.031914923,
-0.026289152,
0.008758606,
-0.0049192174,
0.0058823978,
-0.0029345332,
-0.019596882,
0.023716228,
-0.0039027126,
-0.0175972,
-0.012344703,
-0.03364798,
0.0041060136,
0.026915718,
-0.005822407,
-0.001049833,
-0.022463094,
0.008185364,
0.024542762,
-0.04724582,
-0.014331054,
0.006658941,
0.0009015233,
-0.0058357385,
-0.011291537,
0.0099050915,
0.024529431,
0.004882557,
0.00042659882,
-0.013084586,
-0.008538642,
0.005399141,
0.005555783,
0.007452148,
0.0033927937,
-0.030395165
] |
OBJECTIVE To determine the frequency of moderate and severe hypoglycemia and to identify clinical predictors associated with its occurrence in a large population-based sample of children and adolescents with IDDM. RESEARCH DESIGN AND METHODS A total of 657 patients (age: 12.1 +/- 4.4 years, mean +/- SD) were included in the study, yielding 1,449 patient-years of data. A prospective assessment of severe hypoglycemia (an event resulting in a seizure or coma) and moderate hypoglycemia (an event requiring assistance of another, excluding severe episodes) was made over a 3 | [
0.0028745239,
-0.011130576,
0.033155467,
-0.04559861,
0.0036489388,
0.0075603914,
0.005860616,
-0.0026218544,
-0.00704849,
-0.01307974,
0.006733474,
0.013414444,
-0.002211677,
-0.0077244625,
-0.010080522,
-0.0016366082,
0.038379487,
0.000030635132,
-0.008426687,
-0.009023905,
-0.007527577,
0.006149381,
-0.0015767223,
0.0007473434,
-0.0033027492,
-0.0061067226,
0.00022088058,
-0.031895403,
0.009286419,
-0.007422572,
0.021854257,
-0.031344123,
-0.02105359,
0.0080854185,
0.0028466317,
-0.01418886,
0.0028105362,
-0.0017949367,
0.006533307,
-0.03202666,
0.021289852,
0.009247041,
0.003219073,
0.015606433,
-0.006831916,
0.006890982,
0.0067006596,
-0.021250475,
-0.010605549,
0.00529293,
0.0030008585,
0.03462554,
-0.002669435,
0.0031206303,
0.014241362,
0.0002791258,
0.0055685695,
0.0042625642,
-0.002516849,
-0.03147538,
-0.015383297,
0.003931141,
-0.015619558,
0.0021903478,
0.0010361084,
-0.009306107,
-0.008262616,
0.016695864,
0.0053651216,
-0.015527679,
0.03318172,
0.043944776,
0.0042625642,
-0.019005984,
0.028797742,
-0.010625238,
0.0236656,
-0.026015097,
0.014175734,
0.00020242258,
0.020882957,
-0.007954162,
-0.024531895,
0.04425979,
0.00030865855,
-0.0030254691,
-0.0067859762,
0.0055751326,
-0.026960146,
0.005877023,
-0.009404549,
0.00070058316,
0.014293865,
0.014753263,
-0.0041706846,
0.014083854,
-0.009457052,
0.033129215,
0.0098902,
0.016393974,
-0.008046041,
0.009667063,
-0.005548881,
-0.018428454,
-0.013755713,
-0.0008654745,
-0.017732793,
0.0026612314,
-0.0013109272,
-0.0034914308,
-0.0039114524,
0.06725598,
-0.008899211,
-0.008800768,
-0.034914307,
0.015973952,
-0.0020935459,
-0.007895096,
-0.0069894246,
-0.00931267,
0.017260268,
0.0022067549,
0.022996191,
-0.0250963,
0.0019360378,
0.01259409,
-0.027642682,
-0.025266932,
-0.005023854,
-0.024321884,
-0.016827121,
0.0015578541,
0.04194967,
-0.0058113947,
-0.006559558,
0.026225109,
-0.036988165,
-0.00922079,
-0.023560595,
-0.016840247,
-0.00864326,
0.022615546,
-0.013913221,
-0.003891764,
-0.011242145,
0.02648762,
0.03438928,
0.010992757,
-0.021001088,
-0.0031091454,
-0.011294647,
0.01192468,
-0.012154379,
0.033732995,
0.0357806,
0.020935459,
0.018402202,
0.02636949,
-0.029480277,
-0.0046858676,
-0.019675395,
-0.013270062,
-0.022536792,
0.0031780552,
-0.012259385,
0.000007684419,
0.0014216752,
-0.027327664,
0.015028903,
0.014411996,
-0.02117172,
0.038379487,
-0.014950149,
-0.0029549187,
0.0021017494,
0.01777217,
0.020620443,
0.0031075047,
-0.032210417,
-0.027826441,
-0.027642682,
0.029847795,
0.009785194,
0.008210112,
-0.02086983,
0.0013486636,
0.024440015,
0.0029795293,
0.0014791,
-0.018887853,
0.027826441,
0.025647579,
-0.0083807465,
0.0066087795,
-0.64851356,
-0.0039180154,
0.026054474,
0.0021296416,
0.0047088377,
0.03050408,
0.0072388123,
0.026041348,
0.004679305,
0.024689402,
0.01231845,
0.029611534,
-0.011911554,
-0.02858773,
0.005368403,
-0.021644246,
-0.023652475,
-0.0053421515,
0.013224122,
-0.035754353,
-0.008203549,
0.008137922,
-0.02077795,
0.017903427,
-0.00009008523,
0.010546484,
0.011754046,
-0.03202666,
0.012443144,
0.010415227,
0.016078958,
0.0034290839,
0.014687636,
0.023928113,
0.044469804,
-0.029112758,
0.008151047,
0.019911656,
-0.0033929881,
0.028745238,
-0.027170157,
-0.010933691,
0.032499183,
0.0202923,
-0.011124014,
0.030005304,
-0.008013227,
0.0058573345,
0.030005304,
-0.0058212387,
0.015042028,
-0.0003061975,
-0.008676074,
0.0029844514,
0.017549034,
-0.03050408,
0.005539037,
0.0017965774,
-0.005624354,
-0.0063889246,
-0.022969939,
0.012377515,
-0.012640029,
0.0005886047,
-0.016997755,
0.024860037,
-0.0013388193,
0.008144484,
0.023691852,
-0.0035767476,
0.025122551,
0.019071613,
0.0008687559,
0.019832902,
0.035071816,
-0.0076653967,
0.01999041,
0.03242043,
-0.016052706,
-0.0011189642,
0.004259283,
0.014727012,
-0.014241362,
0.0018097031,
0.014215111,
0.021421108,
-0.01661711,
0.015199537,
-0.0033634554,
-0.008984528,
0.0049352557,
0.0029680443,
0.0076850853,
-0.018179066,
-0.028062703,
0.019964159,
-0.02135548,
-0.0035340893,
0.037775706,
-0.005502941,
-0.007416009,
-0.016866498,
0.00038966862,
-0.012167505,
0.0048597828,
0.02919151,
-0.02065982,
-0.00640205,
0.022011764,
-0.027485173,
-0.0152126625,
0.004954944,
-0.010631801,
0.0047154003,
0.012213445,
-0.028115205,
-0.002879446,
0.00873514,
-0.0077638393,
-0.02403312,
0.0012559635,
-0.0008400435,
0.027143905,
0.009975516,
-0.009667063,
-0.009470178,
0.006805665,
-0.00501401,
0.0054274686,
-0.03129162,
0.008459501,
-0.0041608405,
0.025936343,
-0.011032133,
0.024006868,
-0.020502312,
0.02591009,
-0.03341798,
-0.0072650635,
-0.019951032,
-0.0025529447,
0.0014594115,
0.0010902517,
-0.0015176567,
-0.029532779,
0.0005299493,
-0.013270062,
-0.008229801,
0.019531012,
-0.004508671,
0.011294647,
-0.0015233991,
0.003760507,
0.012797537,
-0.014372619,
-0.028115205,
-0.008754828,
-0.027301414,
0.02020042,
0.016656488,
0.006664564,
0.01324381,
-0.006618624,
-0.0030024992,
-0.020462934,
-0.028220212,
-0.004649772,
0.011038696,
-0.026080726,
-0.012029685,
-0.015908323,
-0.023219327,
0.001629225,
0.015672062,
0.011852489,
0.030372823,
-0.010664615,
-0.010881188,
-0.008544818,
-0.006831916,
0.008321681,
0.012745035,
-0.030687839,
0.009818008,
0.016275844,
-0.0097195655,
0.006628468,
0.0035111194,
-0.00063126313,
0.016210215,
-0.016787745,
0.03609562,
-0.017614663,
0.017627787,
-0.01701088,
0.002364263,
0.012475958,
-0.013060051,
-0.025621327,
0.027196407,
0.061690696,
-0.029690288,
0.006805665,
-0.0045742993,
0.03840574,
-0.023468716,
0.016341472,
-0.008571069,
0.013099428,
-0.009844259,
0.007698211,
-0.008636697,
0.0135719525,
-0.0027088122,
-0.015619558,
0.002953278,
-0.007632583,
0.003461898,
-0.015304542,
-0.00056768564,
0.03307671,
-0.009699877,
0.03654189,
0.009187976,
-0.0014380823,
0.010093648,
0.02503067,
-0.004525078,
0.0075341403,
-0.0013683521,
-0.004840094,
0.011550598,
0.01816594,
0.02190676,
0.0043708514,
0.027091403,
0.0017768889,
-0.02102734,
0.022287404,
0.028167708,
-0.02403312,
0.019281624,
0.026671382,
-0.0029631222,
-0.009168287,
-0.016236465,
0.022379283,
-0.00653987,
-0.016630236,
0.030267818,
0.009397986,
0.0024971606,
0.011019008,
-0.0049811956,
-0.012495647,
0.0027580333,
-0.0077638393,
-0.00062387995,
0.0060673454,
0.026001971,
0.0109074395,
0.018284071,
0.0033552519,
-0.0010418508,
0.015960826,
-0.006533307,
0.006159225,
0.005955777,
0.018179066,
-0.014713887,
-0.026474496,
-0.008144484,
-0.00090813293,
-0.010526795,
0.0056145093,
0.003540652,
0.0071469327,
-0.021788629,
0.029821545,
0.02591009,
-0.0021247193,
-0.020502312,
0.017102761,
0.013296314,
-0.009404549,
-0.005066512,
-0.00633314,
-0.005181362,
0.006267512,
0.008715452,
-0.006080471,
0.018126564,
0.011320898,
-0.021696748,
0.015435799,
0.0021345636,
0.028062703,
-0.00425272,
-0.021119218,
-0.0067400364,
0.004672742,
0.005135422,
-0.020134792,
-0.0068516047,
0.01728652,
-0.0038031656,
-0.013237248,
-0.015987078,
-0.018966608,
0.017601537,
0.0076653967,
-0.010297095,
-0.0024758314,
0.02706515,
0.016525231,
-0.0126859695,
-0.03032032,
0.011248708,
0.024597524,
-0.0054373126,
-0.0035931547,
-0.02017417,
-0.0033191561,
-0.010060834,
0.029217763,
0.036069367,
0.0040656794,
0.025424441,
0.009502992,
0.020502312,
-0.016787745,
0.00006132154,
0.035596844,
0.014359494,
0.0028023326,
0.0135719525,
0.022366159,
0.0057687364,
0.015567056,
0.020672945,
0.005256835,
-0.012994423,
0.0030796125,
0.030845348,
-0.020804202,
-0.0075997687,
0.020121668,
0.031160364,
0.01130121,
-0.027773937,
0.019937906,
0.027878944,
-0.025778836,
0.00829543,
-0.022576168,
0.013768838,
0.0036555019,
0.027511425,
-0.017850924,
0.00026148814,
0.016328346,
-0.019819776,
0.029322768,
-0.005299493,
0.031816646,
0.0068975445,
0.0068975445,
0.015987078,
0.01317162,
-0.008341369,
-0.008866397,
0.04113588,
-0.009345484,
-0.004587425,
0.035071816,
0.0023609817,
-0.0009237197,
-0.014031352,
-0.0068581677,
-0.0043085045,
0.0046005505,
-0.042028427,
-0.010684303,
-0.019097865,
-0.007422572,
-0.014989526,
0.01962289,
0.0035045564,
-0.033496734,
-0.008459501,
-0.008669511,
-0.023993742,
-0.027511425,
-0.02035793,
-0.004095212,
0.002109953,
-0.028062703,
0.01987228,
-0.001102557,
0.0022248027,
0.010336473,
-0.0135850785,
0.021578617,
-0.004131308,
-0.018520335,
-0.006113285,
0.017942805,
-0.0033273597,
0.013716335,
0.01125527,
0.019583514,
-0.0055160667,
-0.014057603,
0.00762602,
-0.019662268,
-0.006726911,
0.012863166,
0.0013068254,
-0.0048433756,
-0.026054474,
0.01576394,
0.008846708,
-0.029637784,
-0.030136561,
0.0010155995,
-0.029086506,
-0.035413083,
-0.017325897,
0.0063987686,
0.0042330315,
-0.026238233,
-0.010428352,
0.011635915,
-0.025385065,
0.003711286,
0.009988642,
0.015593307,
0.003937704,
0.051321406,
-0.0011673651,
-0.016905876,
0.011596538,
0.0016005125,
-0.0030960196,
0.0063889246,
0.0024823942,
0.020791076,
0.0069106705,
-0.034835555,
0.021263601,
0.001100096,
-0.03625313,
-0.04229094,
-0.0207517,
-0.0036522204,
0.040820863,
0.00048729085,
0.004961507,
-0.026842015,
-0.0017342304,
0.0013724539,
0.012554713,
0.005634198,
-0.025621327,
-0.0003699801,
-0.007855719,
-0.0059590586,
-0.02278618,
0.02086983,
-0.027537676,
-0.009732692,
-0.005243709,
-0.009463615,
0.02579196,
-0.017273394,
0.018402202,
-0.019150367,
-0.0073831948,
-0.011918117,
-0.030005304,
0.008964839,
0.019609766,
0.036830656,
0.024466267,
0.033155467,
0.018690968,
0.010257718,
0.015291417,
0.012587527,
0.020489186,
0.019452257,
0.00017719668,
-0.00021001087,
0.011839363,
-0.009115784,
0.0021690186,
0.0069434843,
-0.030477827,
0.03307671,
0.015383297,
-0.019544138,
-0.022405535,
-0.006119848,
-0.053815287,
0.018310323,
0.0043183486,
0.019832902,
0.0041870917,
-0.046884928,
-0.023429338,
0.007849157,
-0.008722014,
-0.00083963334,
-0.019150367,
0.013808215,
-0.031659137,
0.019557262,
-0.00062429014,
0.020528562,
0.009227353,
-0.025437567,
-0.0016505542,
-0.009338921,
0.001388861,
0.019951032,
0.006480804,
-0.0049188486,
-0.017732793,
-0.012325013,
0.014845144,
-0.02363935,
0.010388975,
-0.0066612824,
-0.016761493,
0.0073110037,
-0.006500493,
-0.018848475,
-0.002278946,
0.0025890402,
0.013184745,
-0.017430903,
0.02008229,
-0.043524753,
0.004689149,
-0.016695864,
-0.020882957,
0.012285636,
-0.004150996,
0.038143225,
0.021158595,
-0.0054274686,
-0.0128369145,
0.019399755,
0.028928997,
-0.0037539443,
0.023442464,
0.0037933213,
0.0016128179,
-0.022825558,
0.010933691,
-0.0002953278,
-0.012449707,
-0.037959464,
0.01266628,
0.010441478,
-0.01670899,
-0.011806549,
-0.030136561,
-0.017719667,
0.039928317,
0.005860616,
0.013178183,
-0.0032617315,
-0.010369287,
0.004374133,
0.025647579,
-0.030241566,
0.0025250525,
0.009502992,
0.01361133,
0.010566172,
-0.019793525,
-0.038143225,
0.004246157,
-0.018520335,
0.0047875918,
-0.012416893,
0.01324381,
-0.0008736781,
-0.0027186563,
0.013742587,
0.008662948,
-0.03438928,
0.029506527,
-0.0007489841,
-0.013453822,
0.008512003,
-0.0052010505,
-0.018375952,
0.0020213546,
-0.011918117,
-0.014556379,
-0.02001666,
0.0061986023,
0.012462833,
0.016879624,
-0.018402202,
0.008190424,
-0.030582834,
-0.008170736,
-0.016078958,
-0.029244015,
0.012777849,
-0.026684506,
0.016919002,
-0.018231569,
-0.0024397357,
0.000995911,
0.015055154,
-0.0016472728,
0.008932025,
0.020607317,
-0.027327664,
0.0016087161,
0.028640233,
-0.0014610522,
-0.010257718,
0.0078032166,
-0.020252924,
-0.030215314,
0.021775503,
0.028351467,
-0.03163289,
-0.006733474,
0.011320898,
0.012626904,
-0.016118335,
-0.00089746836,
0.0040361467,
0.014110106,
0.015987078,
-0.0026710758,
-0.024387512,
0.035964362,
-0.040374592,
0.013342253,
0.018389078,
-0.005781862,
0.01689275,
-0.0019901812,
0.0045546107,
-0.008892648,
-0.029480277,
-0.0054044984,
-0.027458921,
0.05000884,
-0.02193301,
0.013900095,
-0.02743267,
-0.002946715,
-0.020830454,
0.021381732,
0.00700255,
-0.005023854,
-0.031134112,
-0.0146220075,
-0.007422572,
0.010264281,
-0.0028023326,
-0.009949265,
0.014057603,
-0.013676958,
-0.038510744,
-0.0051780804,
-0.018021557,
0.035203073,
0.00048236872,
-0.010546484,
-0.017535908,
-0.0155145535,
-0.021801753,
0.023888737,
-0.017457154,
0.019150367,
0.0018638466,
0.013926346,
0.006890982,
0.038904514,
-0.013637581,
0.019767273,
-0.041424643,
-0.009857385,
0.006697378,
0.0062773563,
0.03517682,
-0.022956813,
-0.013952597,
-0.007895096,
0.01525204,
-0.004452887,
-0.004472575,
0.03131787,
-0.005611228,
0.009640812,
-0.01546205,
-0.00039643655,
-0.000023559569,
-0.023048693,
-0.027642682,
-0.015973952,
-0.01307974,
-0.014451373,
-0.01871722,
-0.00022518744,
-0.038668253,
0.009076407,
-0.020974835,
-0.0095817465,
-0.02992655,
-0.002720297,
-0.010415227,
-0.011524347,
-0.0023183231,
-0.0004409408,
0.017680291,
0.0028187397,
0.0041772476,
0.0134341335,
-0.01670899,
0.017549034,
-0.006759725,
-0.0011402934,
0.012436582,
-0.013322565,
-0.020095415,
0.00023810803,
0.018113438,
-0.018730344,
0.0055751326,
-0.017732793,
-0.01962289,
-0.035859358,
0.008210112,
0.009430801,
-0.034599293,
-0.016840247,
0.011681855,
-0.0114980955,
-0.014254488,
-0.008026353,
-0.0051058894,
-0.022379283,
-0.003013984,
-0.007074741,
-0.00836762,
0.013480073,
0.008807331,
0.0059689027,
-0.023993742,
0.006142818,
0.17924428,
-0.019321,
0.0083873095,
0.014595755,
-0.0048105614,
0.008177298,
0.032604188,
0.014556379,
-0.0033257192,
0.008131359,
0.02251054,
-0.010126462,
-0.0009581746,
-0.0039606737,
0.015173285,
-0.002070576,
-0.026382616,
-0.02743267,
-0.011918117,
-0.034284275,
0.0012912387,
-0.0009327436,
0.014123231,
0.009627686,
0.027091403,
-0.0048072804,
0.0016333268,
0.020791076,
0.031396627,
0.037145674,
-0.00018170863,
0.013808215,
-0.0006669486,
0.014254488,
-0.025818212,
-0.006487367,
0.009187976,
-0.02451877,
-0.0135850785,
0.022576168,
-0.012928794,
-0.012147817,
-0.020620443,
-0.0050205723,
-0.001991822,
0.008433249,
-0.0009056719,
-0.024873164,
-0.026421994,
-0.008630134,
-0.018585963,
-0.0155145535,
-0.007986976,
0.011412779,
0.0017227455,
-0.01241033,
0.002851554,
0.0140182255,
-0.008196987,
0.0036128433,
0.0069894246,
-0.00372113,
-0.0207517,
0.053027745,
-0.004141152,
0.018756596,
-0.011911554,
-0.0022165992,
-0.028456474,
-0.010349599,
0.0037178488,
-0.01871722,
-0.037513193,
-0.0018769722,
-0.0073044407,
-0.017811548,
0.031422876,
0.04189717,
-0.0058048316,
0.015094532,
-0.023206202,
-0.005424187,
0.014031352,
0.00086219306,
-0.030399075,
-0.028666485,
0.025647579,
0.009391423,
-0.029060254,
-0.012850041,
0.0140051,
0.007960725,
0.00015340638,
0.009260167,
-0.028115205,
-0.005240428,
-0.005867179,
-0.0032847014,
0.0014520283,
-0.02558195,
0.0010574376,
0.067571,
0.0030500798,
0.020725448,
-0.005243709,
-0.014490751,
-0.015028903,
-0.0073766317,
0.013965723,
-0.011465281,
0.020489186,
-0.02518818,
0.020554814,
-0.017115885,
0.015265166,
0.013991974,
-0.00008218931,
-0.035675596,
-0.0086826375,
-0.029217763,
-0.0053585586,
-0.014595755,
0.012403768,
0.03032032,
-0.011760609,
-0.01689275,
-0.004383977,
-0.006549714,
-0.009214227,
-0.018651592,
0.0060312496,
-0.040978372,
0.03089785,
-0.0004885214,
0.01236439,
-0.0039344225,
-0.0031255526,
0.003279779,
-0.0005886047,
0.0042494386,
0.011727795,
-0.017706541,
0.0012920591,
0.008013227,
0.014595755,
-0.011452155,
0.028351467,
0.014451373,
-0.008728577,
0.00029286672,
-0.016026454,
-0.015790192,
0.0019212713,
-0.019176617,
0.027485173,
-0.0028023326,
-0.008052604,
-0.027878944,
0.009227353,
-0.009457052,
-0.014937024,
0.020817328,
0.0051616733,
0.016656488,
-0.0042494386,
0.004705556,
-0.16485853,
0.018874727,
0.01649898,
-0.030005304,
0.015567056,
-0.014950149,
0.019426005,
-0.013926346,
-0.007934473,
-0.019491633,
0.034993064,
-0.012357827,
-0.02287806,
0.0053749657,
-0.0036095618,
0.005040261,
-0.017798422,
0.05738547,
0.025555698,
0.007973851,
0.020462934,
-0.0042166244,
-0.0019163492,
-0.002833506,
0.010224905,
0.01892723,
-0.024715655,
0.039534546,
-0.019885404,
-0.017759044,
-0.030766593,
0.0023183231,
0.041372143,
0.008426687,
-0.009115784,
-0.016958378,
-0.014923898,
0.025595075,
-0.01592145,
0.012909106,
0.019636016,
0.011471844,
0.022641797,
0.009227353,
-0.005929526,
0.008951713,
0.028430222,
-0.0010664614,
0.015422674,
-0.0088270195,
0.0197804,
-0.025371939,
0.027327664,
0.010093648,
-0.0050074467,
0.01307974,
-0.0064775227,
-0.0018769722,
0.00011905401,
-0.021407984,
0.005765455,
-0.038642,
0.01037585,
-0.0057851435,
-0.010382413,
-0.023980618,
-0.002465987,
-0.0073110037,
-0.004846657,
0.0022428506,
-0.02591009,
-0.0052305833,
0.017142138,
0.00372113,
0.042080928,
0.025870714,
0.0012436581,
-0.0023773888,
0.0009352047,
-0.01631522,
0.007074741,
0.0077638393,
-0.039298285,
0.0049746325,
-0.00640205,
0.012751598,
0.018874727,
0.015987078,
0.00044914434,
-0.007836031,
-0.0014126513,
-0.025700081,
0.00074611284,
-0.009365172,
-0.002738345,
0.0131322425,
0.005712952,
-0.00046021913,
0.031002855,
0.006438146,
-0.0055226297,
-0.0042625642,
-0.010933691,
0.0070353644,
0.0031682109,
-0.018795973,
-0.009443927,
0.014897646,
0.025463818,
-0.0035275265,
-0.018454706,
0.012521898,
0.008334806,
-0.0022641798,
0.011918117,
0.024860037,
-0.023508092,
-0.010277407,
0.0045283595,
0.015107657,
0.04851251,
-0.010218342,
-0.020279175,
0.00061854767,
-0.026120102,
0.005844209,
-0.120651245,
-0.016603984,
0.013900095,
0.00058081135,
0.03202666,
0.026605753,
-0.0077572768,
-0.008840146,
-0.01731277,
0.041240886,
-0.04229094,
-0.016341472,
-0.0083807465,
-0.011616226,
0.04071586,
-0.0017900146,
0.0065365885,
-0.01920287,
-0.01361133,
0.038563248,
0.000042350825,
-0.004226469,
-0.0147663895,
-0.011937805,
-0.013860717,
-0.011484969,
-0.014228237,
0.0147663895,
0.0019147085,
0.036568142,
0.0036850346,
-0.0029893736,
0.014937024,
0.0049221297,
-0.019846028,
-0.0012854963,
-0.022129895,
-0.02475503,
0.02357372,
-0.033680495,
0.019911656,
0.030582834,
0.012699095,
-0.0055291927,
0.021670498,
0.0197804,
-0.011544035,
-0.020922333,
0.028981501,
-0.019255372,
-0.0067859762,
-0.012259385,
-0.017549034,
-0.008032916,
0.0026940457,
-0.01804781,
0.025148802,
0.001770326,
0.0019048642,
0.009680188,
-0.0006944305,
0.015055154,
-0.02287806,
0.009791757,
0.019517886,
-0.011767171,
-0.029270265,
-0.028403971,
0.013342253,
-0.011412779,
-0.015343919,
0.012561276,
-0.009056719,
-0.0023577001,
-0.031055357,
-0.009693314,
-0.009975516,
-0.0017293083,
-0.0050008837,
-0.014346368,
-0.014700761,
-0.026106976,
0.01002802,
-0.0002879446,
-0.0014077291,
0.0086892,
0.027878944,
-0.00894515,
0.0040197396,
-0.0103167845,
0.019268498,
0.03131787,
0.018914104,
0.0036489388,
0.008301992,
0.018244695,
-0.0014684354,
-0.012272511,
0.014372619,
0.014333243,
0.0095817465,
-0.0025873997,
-0.04402353,
0.028561478,
0.016813995,
-0.011511221,
0.016774619,
-0.018507209,
0.0037178488,
-0.01777217,
-0.0012600652,
0.00487619,
-0.018782847,
-0.0001428443,
-0.035071816,
0.008026353,
-0.03129162,
-0.02743267,
0.0063036075,
-0.015383297,
0.033129215,
0.024203753,
-0.009909888,
0.009929577,
0.002646465,
0.042737212,
0.014477625,
0.0026940457,
-0.0044758567,
0.022825558,
0.0031878995,
-0.010703992,
0.028561478,
-0.024492519,
0.004141152,
0.004797436,
-0.019347252,
-0.04310473,
0.0143201165,
0.018848475,
0.025962595,
0.02047606,
-0.015908323,
-0.015173285,
-0.020620443,
-0.022458037,
-0.006297045,
0.0017883738,
-0.0280102,
0.016065832,
-0.0003935653,
-0.016026454,
0.029427774,
0.0065923724,
0.01901911,
-0.018966608,
-0.03570185,
0.028272714,
-0.01051367,
0.018310323,
-0.009286419,
-0.008754828,
0.018087186,
-0.038694505,
0.019701645,
-0.013729461,
0.025870714,
-0.0173784,
-0.00061116443,
0.013329128,
-0.00092043827,
-0.005598102,
-0.011662167,
0.0019819776,
0.0035504964,
0.024558147,
0.0140051,
0.0064840857,
-0.016380848,
0.03732943,
-0.0063036075,
0.025371939,
0.03861575,
-0.0017194641,
-0.027091403,
0.02533256,
0.026093852,
-0.005765455,
0.006602217,
0.02916526,
-0.018244695,
-0.015317668,
-0.021814879,
-0.005867179,
-0.009653937,
0.004971351,
0.007120681,
0.033838004,
-0.0016743445,
-0.024650026,
0.034651794,
0.0058737416,
-0.011517784,
-0.0020246361,
0.0023199639,
-0.0260676,
-0.009929577,
-0.006713785,
-0.015724564,
-0.023980618,
0.0098902,
-0.00025225917,
-0.0012797537,
0.02424313,
-0.024873164,
0.0098705115,
-0.011189641,
-0.004305223,
-0.020581065,
0.026146354,
-0.018599087,
0.016945252,
-0.0077178995,
-0.0055685695,
0.015580182,
-0.029244015,
0.01603958,
0.010270844,
0.00054389535,
-0.011681855,
0.023901863,
0.011931242,
0.016407099,
-0.018690968,
-0.02348184,
-0.019465383,
0.009614561,
-0.05168893,
-0.008026353,
0.017444028,
0.005703108,
0.07518389,
-0.0080919815,
-0.016407099,
-0.016866498,
-0.005660449,
0.010894314,
-0.013020674,
0.001391322,
-0.0033240784,
-0.010362724,
0.020279175,
-0.014162608,
0.009109221,
-0.045467354,
-0.030399075,
-0.010776183,
0.009338921,
-0.007291315,
-0.007986976,
-0.0022641798,
0.010192091,
-0.0221824,
0.017601537,
-0.016879624,
-0.002817099,
-0.0033798625,
0.029559031,
-0.011097762,
-0.011570287,
-0.026933895,
0.009411112,
0.0070288014,
-0.031501632,
-0.026986398,
0.014871395,
-0.014530127,
0.0026333395,
-0.034100514,
-0.00019965389,
-0.0019278342,
-0.004400384,
0.023035567,
-0.03625313,
0.010067396,
-0.020279175,
-0.030136561,
-0.0024216878,
-0.008964839,
-0.006316733
] |
RATIONALE The outcome of fully intermittent thrice-weekly antituberculosis treatment of various durations in HIV-associated tuberculosis is unclear. OBJECTIVES To compare the efficacy of an intermittent 6-month regimen (Reg6M: 2EHRZ(3)/4HR(3) [ethambutol, 1,200 mg; isoniazid, 600 mg; rifampicin, 450 or 600 mg depending on body weight <60 or > or =60 kg; and pyrazinamide, 1,500 mg for 2 mo; followed by 4 mo of isoniazid | [
-0.019188114,
-0.025114438,
0.0077108038,
-0.03655882,
-0.0039179577,
0.019570032,
-0.008046629,
-0.03400392,
-0.021729847,
0.014565583,
-0.008020289,
0.015764017,
0.017765798,
0.0002245006,
-0.018266242,
0.005610252,
0.032660622,
0.02099235,
-0.0030783953,
-0.0030257166,
-0.013722728,
0.005623421,
-0.025601711,
-0.020386549,
-0.014736788,
0.0052908887,
0.025786087,
-0.019583203,
-0.02402136,
0.0035623782,
0.0058473046,
-0.0085207345,
0.008191494,
-0.014262682,
-0.011016374,
-0.0036743197,
0.016435668,
0.0111875795,
0.023876494,
0.00416818,
0.010107672,
0.0066704047,
-0.008026875,
0.028867774,
-0.0059296144,
0.009146291,
0.023771137,
-0.021216234,
-0.03503115,
0.012497955,
0.0034899453,
-0.00030660487,
-0.009370174,
0.0049879877,
-0.008395623,
-0.0047970284,
-0.026260192,
0.023073148,
-0.0033747114,
-0.015224064,
-0.0072366977,
-0.012491371,
-0.041563272,
0.018055528,
-0.013986121,
0.0047213035,
-0.01602741,
0.0064037205,
0.007131341,
0.036637843,
0.048516825,
0.027234742,
-0.01697562,
0.011720949,
0.04140524,
-0.012879874,
-0.02003097,
0.011240258,
0.029394558,
0.0027178773,
0.020083647,
0.004800321,
-0.008817051,
0.0076647103,
0.029131167,
-0.0023079733,
0.004266952,
0.011464141,
0.00024157994,
0.01367005,
-0.018450616,
0.0012132499,
0.02894679,
0.029842325,
-0.0041385484,
0.024864214,
-0.009620396,
0.032792315,
0.00392125,
-0.0055937897,
-0.0162908,
-0.010878094,
0.0020873824,
-0.0030010238,
-0.017792135,
0.0006127982,
-0.014065138,
0.0032956935,
0.009923297,
-0.010022069,
-0.017607762,
0.052810118,
0.0010231137,
-0.031159285,
0.013880763,
0.010594947,
0.009883788,
-0.0090475185,
0.010990036,
-0.028604383,
-0.017370708,
0.02162449,
0.014381208,
0.0056925616,
0.035531595,
-0.00080334593,
-0.021466456,
-0.027893223,
0.001264282,
-0.000026827925,
0.0058143805,
0.015434777,
0.013235453,
-0.0073947334,
-0.025549034,
0.02236199,
-0.024442786,
-0.023771137,
-0.034767758,
-0.02100552,
0.020241683,
0.02029436,
0.013419827,
-0.020926502,
-0.028420007,
0.023086317,
0.01117441,
0.023441898,
-0.022217123,
0.0037105363,
0.01017352,
-0.01032497,
-0.00898167,
-0.011016374,
0.0048464146,
0.0046982565,
-0.010529099,
0.0077173887,
-0.030500805,
0.007888594,
-0.023204844,
-0.020096818,
0.01667272,
0.00750009,
0.027919563,
0.0070523233,
0.016738568,
-0.017476065,
-0.0017713119,
0.011306106,
-0.0082573425,
0.006999645,
0.0055345264,
0.030263752,
0.003806016,
0.014420717,
-0.0061995913,
0.0025532572,
-0.0118855685,
-0.006219346,
-0.02369212,
0.022085428,
0.010785907,
0.020360209,
-0.023138996,
0.002312912,
-0.012912798,
0.01830575,
0.02334971,
-0.02167717,
-0.0050834673,
0.0011342323,
-0.0143417,
-0.015118706,
-0.6506838,
0.0022701106,
-0.007263037,
-0.003027363,
0.02029436,
-0.0022108473,
0.013321055,
0.0011103624,
-0.024113547,
0.021440117,
0.014828975,
0.031238303,
0.03634811,
-0.021848375,
0.0035261617,
-0.017713118,
-0.012399183,
-0.016936112,
0.010897848,
-0.014855314,
0.0024248536,
0.022901943,
0.0022421253,
0.01116124,
0.01565866,
0.014407548,
0.027550813,
-0.02200641,
-0.0068218554,
0.028235633,
-0.006867949,
0.026470905,
0.017581422,
0.016830755,
0.047858346,
-0.047805667,
-0.013070833,
0.017686779,
0.007921518,
0.020794807,
-0.022098597,
0.010305216,
0.02934188,
-0.016764907,
0.00044941276,
0.030448128,
-0.0050176196,
0.0069272122,
0.025430508,
-0.019701729,
-0.0008276274,
0.016817585,
-0.0034076353,
0.003595302,
0.036479805,
-0.007473751,
-0.0066506504,
0.0060514333,
0.0058407197,
-0.0114509715,
-0.014447057,
-0.006802101,
0.002207555,
0.0018914845,
-0.015777187,
0.000738321,
0.0067230836,
0.016264463,
0.033793207,
0.003700659,
0.017871154,
0.013347395,
-0.016896604,
0.01264282,
0.037796766,
0.007025984,
-0.015118706,
-0.010265707,
-0.013525184,
0.004905678,
-0.019438338,
0.005893398,
-0.017054638,
0.007309131,
0.029473577,
-0.00899484,
-0.02432426,
0.0019507477,
-0.014447057,
0.023125825,
-0.0004187523,
-0.0029401144,
0.019201284,
-0.031185625,
-0.004234028,
0.02138744,
0.019161776,
0.00006404749,
-0.0123201655,
-0.02399502,
-0.0243506,
-0.013004985,
0.018200394,
-0.004052946,
0.010713474,
-0.011720949,
-0.033134725,
-0.012972061,
0.033240084,
-0.016382989,
-0.009205554,
-0.0050933445,
-0.006219346,
0.01663321,
0.01798968,
-0.032528926,
0.025298811,
0.002953284,
-0.0015120353,
-0.039587833,
0.023152165,
0.017423388,
0.024258412,
-0.015645491,
-0.006739545,
0.027076708,
0.00700623,
-0.0073223,
-0.004635701,
-0.013143266,
-0.012497955,
0.012445277,
0.02631287,
-0.005771579,
0.04727888,
0.0048859236,
0.035478916,
-0.010963696,
-0.0021532304,
-0.026971351,
-0.021874715,
0.0014708802,
0.0102261985,
0.004069408,
0.0340566,
-0.03497847,
-0.002798541,
-0.0051163915,
-0.009126537,
-0.008909238,
0.006736253,
-0.0114509715,
-0.0077964063,
0.018858874,
-0.0038883258,
-0.03608472,
-0.0072498675,
-0.035531595,
-0.01734437,
-0.0025795964,
0.01317619,
0.0029944389,
0.010311801,
0.003305571,
-0.016962452,
-0.016646381,
0.014144156,
0.01730486,
-0.00019003329,
-0.025891444,
0.011128317,
-0.020939672,
-0.015579643,
0.020070478,
-0.007025984,
0.015829865,
-0.0038290627,
-0.0050044497,
0.00025557264,
-0.0015145045,
-0.00492214,
0.012853535,
0.0058308425,
0.012925968,
0.024548143,
0.0030076085,
0.019609543,
-0.017146826,
-0.0027919563,
0.034478027,
-0.0023425436,
-0.017844815,
0.0027524475,
0.0067494228,
0.015197724,
0.0044118175,
0.0067889313,
0.011075638,
0.00043665472,
0.030869555,
0.0173312,
-0.025614882,
0.022072257,
-0.020465566,
-0.01116124,
-0.023560423,
0.02496957,
-0.003134366,
0.042827554,
0.012972061,
-0.0079939505,
-0.014605092,
-0.01866133,
0.00031565898,
-0.02366578,
0.0203207,
-0.0013161374,
0.0043031685,
-0.029974021,
-0.003208445,
-0.0075461837,
0.0057979184,
0.01901691,
0.00064695685,
-0.010061578,
-0.002559842,
0.013512014,
0.0055246493,
0.0075264294,
-0.015447946,
0.0049616485,
0.0066671125,
0.018714009,
-0.0025236255,
0.022743909,
-0.0044184024,
-0.014710449,
-0.030553484,
0.029763307,
0.00084697024,
0.00089635624,
-0.003020778,
0.016040578,
0.0067889313,
0.008474641,
0.018239902,
0.02266489,
0.029183844,
-0.0027129387,
0.02566756,
-0.0029252984,
0.014842145,
-0.028103936,
-0.032660622,
0.009343835,
-0.01117441,
-0.010068163,
0.022862434,
0.030369109,
0.03471508,
0.0048958007,
0.022414668,
0.022546364,
-0.018845705,
0.011167825,
-0.013656881,
-0.009146291,
-0.0064992,
0.003957466,
0.0038685715,
-0.013090587,
-0.007190604,
0.017581422,
-0.0046982565,
0.013828085,
0.007914932,
0.0062786094,
-0.007947857,
0.016356649,
-0.0028907282,
-0.024851045,
-0.012530879,
0.021611322,
0.0040101446,
-0.007467166,
0.007565938,
0.009613812,
0.003799431,
0.004546806,
0.016699059,
0.00902118,
-0.0028084184,
0.0230073,
0.027471796,
-0.006344457,
-0.017146826,
0.016501514,
0.013380319,
-0.010647626,
0.005817673,
0.0046653324,
-0.01431536,
0.008566828,
-0.010193274,
-0.0038685715,
-0.007875424,
-0.007190604,
-0.04799004,
-0.014407548,
0.007565938,
0.026655281,
-0.011701194,
0.009258232,
0.017884323,
0.003947589,
0.02431109,
-0.022059089,
0.009620396,
0.02199324,
-0.056892693,
0.0014585338,
-0.035215523,
-0.015092367,
-0.023073148,
0.02664211,
-0.005340275,
0.0074803354,
0.026444567,
-0.009113367,
0.015197724,
0.0203207,
-0.028762417,
0.013057663,
0.00659468,
0.009758677,
0.0076515405,
0.0043097534,
0.014394378,
0.005903275,
0.0064531066,
0.008975086,
-0.025825595,
0.0048266603,
0.011859229,
0.009633566,
0.0030882724,
0.009903543,
0.016804416,
0.014539244,
-0.0068086856,
0.012234563,
-0.0032759393,
0.020821145,
-0.03634811,
-0.0012453508,
-0.00028623315,
-0.009264817,
0.015526964,
-0.007434242,
-0.040825777,
0.012418938,
-0.0114048775,
0.023138996,
-0.011062468,
0.005481848,
0.017831646,
-0.012616482,
0.017739458,
0.008244173,
-0.019161776,
-0.016119596,
0.036242753,
-0.011543158,
-0.023441898,
0.027629832,
0.016382989,
-0.0030619332,
-0.01668589,
0.0024874092,
-0.007137926,
-0.030474465,
0.0019803795,
-0.045882903,
-0.021453286,
-0.0031458894,
-0.040430687,
0.026260192,
0.0061567905,
-0.027050368,
-0.0047410578,
-0.020281192,
0.01183289,
-0.0153425895,
0.00984428,
-0.013347395,
-0.014130986,
-0.019109096,
0.027208405,
0.0050670053,
0.02303364,
0.0043360926,
-0.0011770334,
-0.0096994145,
0.010496175,
-0.014749957,
0.005481848,
0.000081435486,
-0.0203207,
0.00018921019,
0.012893043,
0.012794271,
0.0058407197,
-0.027234742,
0.0054028304,
0.0025318565,
0.0024347308,
0.032765977,
-0.007737143,
-0.00029549302,
0.0015531903,
0.013228868,
0.003519577,
-0.0063378722,
-0.020505074,
-0.010219613,
-0.016066918,
0.0015498978,
-0.015579643,
0.0015243818,
0.0061008194,
-0.015843036,
-0.010588363,
-0.013202529,
-0.023797477,
0.011786796,
-0.006597972,
-0.015790356,
0.0058275503,
0.022730738,
0.019306641,
-0.0074869203,
0.0059724157,
-0.0006531301,
0.0053929533,
-0.008810466,
-0.009896958,
0.013512014,
0.02269123,
-0.025851935,
0.004359139,
0.0016988791,
-0.023046808,
-0.020715788,
-0.001190203,
-0.0030257166,
0.027024029,
0.011240258,
-0.028578043,
-0.021874715,
-0.010930772,
-0.021189895,
0.0045402213,
-0.0038685715,
-0.019227624,
0.023099488,
-0.012359674,
-0.031449016,
0.006357627,
-0.00014064726,
-0.01201068,
0.0058604744,
0.0065420014,
-0.019991461,
0.007901763,
0.0055444036,
-0.0065683406,
-0.023389218,
0.019543694,
-0.031475358,
-0.019122267,
0.005323813,
-0.006176545,
0.008454886,
0.026102157,
0.017133657,
-0.021611322,
-0.017462896,
0.019833425,
0.022045918,
0.0042142738,
0.016593702,
0.012425522,
-0.010779322,
0.023968682,
0.043196306,
0.00043377385,
-0.01766044,
-0.01233992,
0.011042714,
0.014223173,
-0.016251292,
0.0019128851,
-0.007888594,
-0.015922053,
0.000985251,
0.010871509,
-0.00040105561,
-0.0153425895,
-0.031975802,
-0.024903722,
0.042406127,
0.0030800414,
0.020175835,
0.030105717,
0.012405768,
-0.023494575,
0.016066918,
-0.012794271,
0.004941894,
-0.01631714,
0.010311801,
-0.011029544,
-0.02566756,
-0.0043328,
0.0058637667,
0.023165336,
0.0051460234,
-0.008481226,
0.008593167,
0.017370708,
-0.026088987,
-0.020913333,
-0.016567362,
-0.011115147,
-0.024376938,
0.007559353,
-0.014486565,
-0.016211784,
0.00035372734,
0.021729847,
0.011740703,
0.003503115,
-0.010028654,
0.0032545386,
0.017423388,
-0.024508635,
0.0472262,
-0.010878094,
0.0129984,
0.025219794,
0.005053836,
-0.0077898214,
-0.03529454,
-0.010858339,
0.0056958543,
0.0230073,
0.027155725,
-0.0036973667,
0.0070984173,
0.029631611,
-0.0026849532,
-0.0044612037,
-0.03597936,
0.02332337,
-0.0067823464,
-0.012037019,
-0.017489236,
-0.003931127,
-0.022862434,
0.030553484,
-0.010087918,
0.03134366,
0.0018684377,
-0.0027310469,
-0.020518245,
0.026852824,
-0.0007572523,
0.0046982565,
-0.004658748,
-0.01665955,
-0.009758677,
-0.00981794,
-0.035162844,
-0.0011523404,
-0.015553303,
0.042564165,
0.010792491,
0.010673964,
-0.0073486394,
-0.015724508,
-0.030421788,
0.014183665,
-0.019148605,
0.029183844,
-0.030922232,
-0.023441898,
0.014631432,
-0.003356603,
-0.0046817944,
-0.009521624,
-0.0114048775,
0.006462984,
-0.029104827,
0.0121489605,
0.009554548,
0.019899273,
-0.0019128851,
-0.014065138,
-0.0064135976,
-0.012083112,
0.010917602,
-0.033240084,
0.019056419,
-0.050861016,
-0.010601532,
-0.0197149,
0.019872934,
0.025483185,
-0.0103974035,
0.002247064,
-0.011483896,
0.002117014,
-0.040773097,
0.015922053,
0.022164445,
0.0009383343,
-0.007473751,
-0.0034043428,
-0.0236131,
-0.05170387,
-0.008915823,
-0.008125646,
-0.0366115,
-0.019899273,
-0.010752982,
0.00052390335,
-0.027919563,
-0.047252543,
0.030237412,
0.008454886,
0.014302191,
-0.010568608,
-0.021519134,
0.01432853,
-0.009587472,
0.010357894,
-0.0015515441,
-0.0012585204,
0.0072827917,
0.00007238139,
0.03334544,
0.0149870105,
-0.026905503,
0.013801746,
-0.009034349,
0.021229403,
-0.02533832,
0.002207555,
0.0062621473,
-0.0019655635,
-0.0073223,
0.010752982,
-0.008151986,
-0.0030076085,
-0.019622711,
-0.016462006,
-0.0025861813,
-0.0038422323,
-0.019425167,
-0.0017071101,
0.022770246,
0.006146913,
-0.030632501,
-0.014117816,
-0.010186689,
0.04535612,
0.003684197,
-0.011859229,
0.0006951082,
-0.01636982,
-0.05043959,
-0.0045237592,
-0.023718458,
0.0059757084,
0.0041220863,
0.0058308425,
0.012761347,
0.036400788,
-0.00023684712,
0.0045566834,
-0.017884323,
-0.014776297,
0.009561134,
-0.01995195,
0.023810646,
-0.0066177263,
-0.0666382,
0.021400608,
0.023481406,
-0.012155545,
-0.012827195,
0.017265351,
0.009778432,
-0.012932552,
0.004536929,
-0.0045797303,
-0.020399718,
-0.006624311,
-0.0005325459,
-0.0045566834,
-0.0130642485,
0.015263572,
0.022401499,
-0.0068481946,
-0.023020469,
0.018832535,
0.012794271,
0.0046719173,
-0.012300411,
-0.008283681,
0.004217566,
-0.044934694,
0.013465921,
0.027208405,
0.017713118,
-0.0073749786,
-0.011134901,
-0.0111875795,
-0.0026520293,
0.032607943,
-0.02398185,
-0.00899484,
0.02528564,
0.013538354,
-0.0041155014,
0.013604202,
0.0045402213,
0.020123156,
-0.008566828,
0.015856205,
-0.010766152,
-0.0020758589,
0.0035985946,
0.035531595,
0.0011004851,
-0.0074869203,
-0.015526964,
-0.0029993774,
0.004178057,
-0.020544583,
0.0052480875,
-0.032502584,
0.0039739283,
-0.03160705,
-0.015540134,
0.009040934,
-0.005267842,
-0.012221393,
0.00096631976,
0.027050368,
0.17857984,
-0.002018242,
0.004052946,
-0.0019754407,
-0.0025911198,
0.018766686,
0.02664211,
0.0021449993,
-0.0072301133,
0.03302937,
0.00416818,
-0.008533904,
0.00060333253,
-0.00021647538,
0.003447144,
-0.020439226,
-0.01698879,
-0.004734473,
-0.020913333,
0.0024808242,
0.00033685382,
-0.0012346505,
0.000668769,
-0.009238478,
0.024943233,
-0.000089769375,
-0.027366439,
0.009416267,
-0.0011474019,
-0.011872399,
-0.009528209,
-0.021466456,
-0.0048958007,
-0.006756007,
-0.014591922,
-0.013268377,
-0.0154216075,
-0.018911554,
-0.009139705,
0.010390818,
-0.007954441,
0.009975975,
-0.04237979,
-0.021282082,
-0.0008321544,
0.008217834,
-0.013538354,
-0.0092187235,
-0.00782933,
-0.025825595,
-0.029183844,
-0.027498135,
0.020254852,
0.027392779,
0.008151986,
-0.03263428,
0.016527854,
0.004349262,
-0.023218013,
0.024390109,
-0.0039014954,
-0.00059304375,
-0.022388328,
0.017397048,
0.0012074881,
0.046831116,
-0.024126716,
0.009910128,
-0.015935222,
-0.0026141666,
-0.0060777725,
-0.0051098065,
-0.018608652,
0.002716231,
-0.011562913,
-0.007368394,
0.02104503,
0.033477135,
0.009159461,
0.021914223,
-0.0066835745,
-0.017107317,
0.003937712,
0.024442786,
-0.029789647,
-0.020254852,
0.005080175,
0.0135910325,
-0.0052645495,
0.033292763,
0.0027211697,
-0.01367005,
0.011641931,
-0.0025022249,
0.015790356,
-0.0015992839,
-0.018081868,
0.0004292468,
0.00516907,
-0.0064300597,
-0.012794271,
0.08402208,
-0.005669515,
-0.0027557397,
-0.0025170408,
-0.015764017,
0.0029187137,
-0.0018009435,
-0.006933797,
-0.017620932,
0.02066311,
-0.047252543,
-0.000861786,
-0.014104647,
0.02931554,
0.0018700839,
0.013617371,
-0.034504365,
0.019174945,
-0.000016191927,
0.024508635,
-0.020544583,
-0.010594947,
0.013788576,
-0.041773986,
-0.017792135,
-0.0061403285,
0.011154655,
-0.007934687,
-0.006295071,
-0.0053962455,
-0.019188114,
-0.0101801045,
-0.011674855,
0.0033434334,
0.010562023,
-0.011207334,
-0.023283862,
-0.011859229,
0.0055279415,
0.018266242,
0.014368039,
-0.00010576839,
0.0022108473,
0.009113367,
-0.0325816,
0.029420897,
-0.0010560377,
-0.017107317,
-0.001985318,
-0.009330665,
-0.020491906,
-0.0039673434,
-0.016725399,
0.02568073,
-0.017199503,
-0.012135791,
-0.029078487,
-0.012899628,
0.016896604,
-0.02870974,
-0.00850098,
0.03874498,
0.0064959074,
-0.021347929,
0.03268696,
-0.16635846,
0.027366439,
0.03302937,
-0.0018190517,
0.039535154,
-0.0017120487,
0.014697279,
0.005504895,
-0.020281192,
-0.0058802287,
0.013880763,
0.006163375,
-0.032265533,
-0.008342945,
0.0014453641,
0.0045007123,
-0.032133836,
0.026892334,
0.037902124,
-0.0037730918,
0.025878273,
-0.035874005,
0.025917783,
-0.026299702,
0.004790444,
0.0114048775,
-0.0102261985,
-0.0031771671,
-0.005317228,
0.00068646565,
-0.014368039,
0.0134988455,
0.036795877,
-0.008606337,
0.008026875,
-0.006146913,
-0.0061106966,
0.005755117,
-0.0020692742,
0.01435487,
0.028235633,
-0.002749155,
0.0104434965,
-0.0015721216,
-0.032844994,
0.02894679,
0.0015630674,
-0.009040934,
-0.0114509715,
0.00028335227,
0.005119684,
-0.009396513,
0.004866169,
-0.0014132633,
0.00088730216,
-0.0059855855,
-0.002176277,
0.0069733057,
0.017054638,
-0.005267842,
-0.015869373,
-0.009363589,
0.040378008,
-0.020807976,
0.01098345,
-0.03932444,
-0.008606337,
-0.01605375,
0.018490124,
0.026773807,
-0.0186745,
0.011892153,
-0.020149495,
-0.013090587,
0.012063358,
0.025404168,
-0.0124123525,
0.0038126006,
0.0038455247,
0.01997829,
-0.002559842,
0.017541913,
-0.021150386,
0.013801746,
0.005521357,
0.026510416,
0.0040167295,
0.013656881,
-0.0058110883,
-0.016606871,
0.0068416097,
-0.010700304,
0.0033417873,
-0.0103974035,
0.01903008,
0.009297741,
-0.008928992,
-0.00474435,
0.005903275,
-0.026299702,
0.011944831,
-0.009258232,
-0.022164445,
0.018608652,
0.044802997,
-0.008540489,
-0.0038422323,
-0.010074748,
0.029183844,
-0.002312912,
-0.0052908887,
0.014407548,
0.0037138285,
0.025470017,
0.0197149,
0.006235808,
-0.00933725,
-0.015816696,
0.014420717,
-0.011977755,
0.039482474,
-0.013959781,
-0.051387798,
0.005883521,
-0.026800146,
-0.040219974,
-0.12000144,
0.003964051,
0.017410217,
0.004135256,
0.009416267,
0.03429365,
0.004118794,
0.0036084717,
-0.00091940304,
0.001960625,
-0.022822926,
-0.01731803,
-0.023889663,
-0.00062473316,
0.021084538,
-0.006268732,
0.021980071,
0.006209469,
-0.01698879,
0.025496354,
-0.01772629,
-0.01232675,
0.021756187,
0.0071115866,
0.025456846,
-0.009126537,
-0.017581422,
0.017634101,
0.011971171,
0.01665955,
0.0023622978,
-0.020584093,
0.0015005119,
-0.0016750091,
-0.011213918,
-0.003536039,
-0.000828862,
-0.0077108038,
0.036137395,
-0.021861544,
-0.0008214541,
0.013432997,
-0.007961026,
0.005383076,
0.04767397,
-0.007467166,
-0.021163555,
0.00717085,
0.017041469,
-0.0015120353,
-0.016462006,
-0.026576262,
-0.026194343,
-0.015092367,
0.0073815635,
-0.0130642485,
0.015566473,
0.0036710275,
0.0102722915,
0.017410217,
0.0033286177,
-0.02467984,
-0.0065354165,
0.04000926,
0.011292936,
-0.02602314,
0.013228868,
-0.018068697,
0.0072432826,
-0.009284572,
-0.008777542,
-0.022296142,
-0.022875603,
0.0042537823,
-0.0487012,
0.009659905,
-0.014275852,
-0.034925792,
0.005350152,
0.0075264294,
-0.0041879346,
-0.0042768293,
0.005570743,
0.0018832535,
0.01833209,
0.003519577,
0.00028438115,
0.0076186163,
0.0040331916,
-0.00898167,
0.0071445107,
0.03194946,
-0.014736788,
-0.017871154,
0.011332445,
0.018266242,
-0.013123511,
-0.029789647,
0.004925432,
0.017041469,
-0.031106606,
-0.027445456,
-0.060896255,
0.010897848,
0.01266916,
-0.009100197,
0.01665955,
0.00037430486,
0.011865814,
-0.0009712584,
0.007612032,
0.0034800682,
-0.018174054,
0.0075461837,
-0.03574231,
-0.0059296144,
0.0023573593,
0.011582668,
0.010410572,
-0.010081332,
0.020057308,
0.012702084,
0.005636591,
0.020847484,
-0.015856205,
0.025483185,
-0.014631432,
0.000054376065,
-0.017686779,
0.016066918,
-0.023850154,
0.01468411,
0.014868484,
-0.012287241,
0.005728778,
0.008079553,
-0.00053954223,
-0.0012749824,
0.0055016023,
0.022520024,
0.007954441,
0.013274962,
0.0067230836,
-0.008573413,
0.027708849,
-0.015540134,
0.0072301133,
0.010292047,
-0.01663321,
0.020728959,
-0.013235453,
-0.003183752,
-0.0028347576,
-0.003200214,
-0.0145524135,
-0.0203207,
-0.028182955,
-0.007058908,
0.00015165623,
-0.024074038,
-0.008777542,
-0.017212674,
0.013577863,
0.00750009,
-0.014117816,
0.009594057,
-0.012754763,
-0.022441007,
0.0058045033,
-0.0008025228,
-0.008382454,
0.0039113727,
-0.0071050017,
-0.009870619,
-0.0014272559,
0.016909773,
-0.0010041824,
0.026115326,
0.013268377,
0.03703293,
-0.0053929533,
0.0076647103,
0.006966721,
-0.0186745,
-0.01798968,
0.008968501,
0.00534686,
0.018832535,
-0.008547073,
0.018924722,
-0.019543694,
-0.01901691,
-0.014394378,
0.016857095,
-0.009462361,
0.0062753167,
0.009547964,
0.030869555,
0.01796334,
-0.008560243,
-0.008217834,
0.04970209,
0.004217566,
-0.0015655368,
-0.0101801045,
-0.0074935053,
-0.007835915,
0.009752093,
-0.03632177,
-0.023455067,
-0.01432853,
0.012879874,
-0.0014675879,
0.027366439,
0.012649406,
0.0030323016,
-0.0071050017,
-0.0035096998,
-0.012399183,
-0.028182955,
-0.016593702,
0.045882903,
0.0012601665,
0.0446713,
0.0047476427,
-0.011543158,
0.021242572,
-0.014868484,
0.0065848026,
-0.021374268,
0.036585163,
0.005613544,
-0.0016387927,
0.022059089,
-0.025127606,
-0.01767361,
-0.016606871,
-0.02398185,
0.01565866,
0.0029022517,
0.00025310335,
0.077226564,
0.0011103624,
-0.02669479,
0.029104827,
0.017094146,
0.015303081,
0.012188469,
-0.0045336364,
-0.012544049,
-0.031053929,
-0.00733547,
-0.02267806,
0.020873824,
-0.024916893,
-0.028578043,
0.043143626,
0.013972951,
0.021545473,
0.015289911,
-0.004833245,
0.025325151,
-0.0068481946,
-0.003806016,
-0.0083034355,
-0.025799256,
-0.0061139893,
0.019583203,
0.010792491,
-0.00025351488,
-0.047515936,
-0.012603312,
-0.004036484,
-0.014407548,
-0.02894679,
0.01864816,
-0.027182065,
-0.031080268,
0.0092187235,
0.0059361993,
-0.01934615,
-0.019056419,
0.028103936,
-0.019925613,
-0.017805306,
0.0034998225,
-0.031396337,
0.00049715256,
0.021374268,
-0.030421788
] |
Mouse pluripotent stem cells (PSCs) are the best studied pluripotent system and are regarded as the "gold standard" to which human PSCs are compared. However, while the genomic integrity of human PSCs has recently drawn much attention, mouse PSCs have not been systematically evaluated in this regard. The genomic stability of PSCs is a matter of profound significance, as it affects their pluripotency, differentiation, and tumorigenicity. We thus performed a thorough analysis of the genomic integrity of 325 samples of mouse PSCs, including 127 induced pluripotent stem cell ( | [
-0.00635139,
-0.0062170904,
0.0046316995,
-0.022274086,
-0.017753758,
-0.0013782091,
-0.016089752,
0.009204439,
-0.029690046,
-0.015460836,
0.014596078,
0.0019342423,
-0.00045653686,
0.0070032347,
-0.007999017,
0.023034025,
0.027646072,
-0.005866601,
0.0017786513,
0.009643369,
-0.023518814,
-0.0021062114,
-0.009256848,
-0.013272734,
0.0118511235,
0.023020923,
0.017439298,
-0.02666339,
-0.005149245,
-0.021736888,
0.0057159234,
0.008962044,
-0.01324653,
-0.0022961963,
-0.025248332,
-0.014831921,
0.01749171,
-0.01717725,
0.010095402,
-0.01390165,
-0.00025099292,
0.020898333,
-0.014216107,
0.0045891167,
0.0152643,
0.001485485,
-0.017137943,
0.0020865577,
-0.0017458952,
0.008523113,
0.011975597,
-0.0033345616,
-0.008549319,
0.014111289,
-0.021540351,
-0.01842198,
-0.008300372,
0.013940957,
-0.0030070017,
-0.009794046,
0.017688245,
0.0052540638,
-0.027384024,
0.021186586,
0.006878762,
0.0055685216,
-0.0083593335,
-0.0072194245,
0.014727102,
-0.0068329033,
0.040381607,
0.015172583,
-0.012787946,
-0.010200221,
0.013560988,
0.008863776,
-0.027226795,
0.003940548,
0.0029038202,
0.01897228,
0.011241863,
-0.019365352,
0.016495926,
0.0045006755,
-0.00618761,
0.030659623,
0.0064693117,
-0.008699995,
0.005581624,
-0.0020734554,
0.018448183,
0.03914998,
0.006302256,
0.00618761,
-0.017321378,
-0.0034459322,
0.00034455227,
0.015644269,
-0.002748229,
-0.029585227,
-0.009178233,
0.020400442,
-0.010953609,
-0.02371535,
-0.027436433,
-0.0006211358,
0.019797731,
-0.0125914095,
0.015133276,
0.0032690496,
-0.0057585062,
0.03804938,
-0.014347131,
-0.030292757,
0.038835526,
0.013547885,
0.008595177,
0.011543217,
-0.012807599,
0.0008201286,
0.04046022,
0.00085493183,
0.028982516,
-0.015290505,
0.0123883225,
0.027384024,
-0.020400442,
0.017819269,
-0.0065970602,
0.013266183,
0.013560988,
-0.019260533,
0.0017000368,
0.0025893624,
-0.018015806,
-0.01303034,
-0.010010236,
0.0024812676,
-0.016115956,
-0.043631002,
-0.0058141914,
0.02556279,
0.0068066986,
0.0007492937,
0.00556197,
0.009479589,
0.015853908,
0.0070621953,
0.0034524833,
0.022942308,
0.030214142,
0.0046349755,
0.035455104,
0.007933505,
-0.0118511235,
-0.00216681,
0.018880563,
0.016928306,
-0.024435982,
-0.022064447,
-0.009473038,
-0.009335463,
0.0055455924,
0.012637268,
0.011589075,
0.03220571,
0.018801948,
0.0017033125,
0.0042124228,
-0.0136002945,
-0.001976825,
0.031524383,
-0.015827704,
0.02714818,
-0.0040355404,
0.015146378,
-0.009564755,
0.012447284,
-0.0239905,
-0.022260984,
-0.014438849,
0.017793063,
0.023793966,
0.02426565,
-0.021409327,
-0.0044351635,
0.02023011,
-0.01264382,
-0.000020881955,
-0.002921836,
-0.005008394,
-0.014530566,
0.005227859,
-0.015880113,
-0.638978,
-0.032991853,
-0.0032985301,
-0.0067084306,
0.036817756,
0.033568356,
0.017308274,
-0.020361135,
-0.027200589,
0.017229661,
-0.011209106,
-0.00023973304,
0.024449084,
-0.014085083,
-0.024134627,
-0.019758424,
0.005073906,
-0.021265201,
0.039071366,
-0.002306023,
-0.030685829,
0.022771977,
0.003028293,
0.027279204,
0.010259182,
-0.005276993,
0.028982516,
0.0068984153,
-0.012781395,
0.028379805,
-0.026296524,
0.011137043,
-0.02796053,
-0.023951193,
0.033463538,
0.010730868,
-0.026375137,
0.033882815,
0.012846907,
0.05117799,
-0.0041632885,
0.01014126,
0.014085083,
0.01521189,
-0.020518364,
0.028484626,
-0.008582074,
-0.0030233797,
-0.0075535355,
0.023007821,
0.015185686,
-0.008077632,
0.0024321335,
-0.0021799123,
0.014687794,
-0.01985014,
0.030214142,
-0.0093682185,
0.015028457,
-0.01281415,
0.01619457,
0.020845924,
-0.01629939,
-0.018867461,
-0.010042992,
0.0332539,
-0.016941408,
-0.005997625,
0.011510462,
-0.03220571,
0.016443517,
0.023138845,
-0.031157516,
0.0026253941,
-0.0067084306,
0.023296073,
0.0136658065,
-0.013181018,
0.011385988,
0.007311141,
0.013927855,
-0.008601728,
-0.0017884781,
0.0111763505,
0.032913238,
0.009774393,
-0.007527331,
0.012611063,
-0.0046153218,
0.019312942,
0.011117389,
0.005083733,
0.017531015,
-0.04491504,
-0.017426196,
-0.0009875937,
-0.01531671,
-0.01771445,
0.0025304016,
-0.023623634,
-0.03899275,
0.011982148,
0.0018949352,
0.007926954,
0.025326947,
0.0042091473,
-0.028746674,
0.018461287,
0.017688245,
-0.03839004,
0.02573312,
0.005260615,
0.020531466,
-0.016312493,
0.0070884004,
-0.022260984,
-0.003488515,
0.012178684,
-0.029218359,
-0.013207222,
0.01814683,
-0.011169799,
-0.004441715,
-0.0018769193,
0.0054276707,
0.011058428,
0.002314212,
-0.0066298163,
0.0007108054,
-0.0028055522,
0.006616714,
-0.014635385,
0.011366335,
-0.042504195,
0.01902469,
-0.002060353,
-0.00498874,
-0.013705114,
0.019614298,
-0.0058698766,
-0.02775089,
-0.010986365,
-0.0011177988,
0.0047234166,
-0.03265119,
-0.032179505,
-0.007311141,
-0.024409778,
0.021265201,
0.008968595,
-0.004539983,
-0.0256283,
0.0044449903,
0.013796831,
0.016600745,
-0.0054931827,
-0.01967981,
-0.02050526,
0.025261434,
-0.0100823,
-0.02245752,
0.03390902,
-0.010770176,
0.00681325,
0.003920894,
-0.013403758,
-0.021933423,
0.0022044794,
-0.019116407,
-0.03134095,
-0.0053719855,
0.000042378088,
-0.00045981247,
0.022378905,
-0.011222209,
-0.0023371412,
-0.021723785,
-0.0158146,
-0.01357409,
-0.01455677,
-0.0012725709,
-0.020361135,
-0.00010149245,
-0.007533882,
0.025982067,
0.02081972,
0.025654506,
0.004726692,
-0.010364001,
0.030712035,
0.0063317367,
0.008621382,
-0.005516112,
0.01341031,
0.0117856115,
-0.029349383,
-0.0023125743,
0.005073906,
0.008608279,
0.028353602,
0.02497318,
-0.012689678,
-0.0018245097,
-0.039045162,
0.028641853,
-0.046854194,
0.0016951235,
-0.016613849,
-0.0075797406,
0.03320149,
-0.0076780086,
0.023833271,
-0.028012939,
-0.012407976,
0.012106621,
-0.0017262417,
-0.010416411,
-0.023741554,
-0.00035519796,
-0.020033576,
-0.011169799,
0.01455677,
0.010383654,
-0.014923638,
0.010855341,
0.018932972,
0.009407526,
0.018081317,
0.002437047,
0.0059877983,
-0.013770626,
0.010829137,
0.011202555,
0.0018015804,
0.035612334,
0.0094992425,
0.024580108,
-0.011634935,
0.023296073,
0.0077107647,
0.011091185,
0.0042484542,
0.00045121403,
0.005299922,
-0.020688696,
-0.027121976,
0.034249682,
0.0013036891,
-0.010868444,
0.000049210787,
-0.037525285,
-0.0037210826,
-0.013534782,
0.017622733,
0.0046742824,
-0.019260533,
-0.0071670148,
0.009237194,
0.026401343,
0.01025263,
-0.009381321,
-0.011281169,
0.012159031,
-0.022339597,
0.022378905,
-0.0011890432,
0.004982189,
-0.0042550056,
-0.002682717,
-0.0026712525,
-0.023623634,
0.02043975,
0.013122058,
-0.017137943,
-0.0016869345,
0.0015026819,
0.031288538,
0.010881546,
0.005647136,
-0.0036522949,
-0.0072718337,
-0.043526184,
0.008208656,
0.028379805,
-0.00072104164,
-0.002764607,
-0.038887933,
-0.026571674,
-0.015578758,
-0.0034754125,
0.0025451418,
0.005211481,
0.0023436924,
0.002741678,
0.00095893216,
-0.023558121,
0.00009386644,
-0.016417312,
0.012480039,
0.0032018998,
0.013967162,
-0.021409327,
-0.012217991,
-0.021514146,
0.0147402035,
0.015369119,
-0.011399091,
-0.020675592,
0.0054506,
-0.012368669,
-0.0018818327,
-0.039097574,
-0.011405642,
-0.0032182778,
-0.012244196,
0.0075469846,
0.010770176,
-0.01286656,
0.06110961,
0.004726692,
-0.016482824,
-0.039123777,
-0.019889448,
-0.010416411,
0.030083118,
0.018382672,
0.0023518815,
-0.006426729,
0.014438849,
-0.01029849,
-0.0036588463,
-0.029008722,
0.02043975,
-0.00036236335,
-0.0050771814,
-0.006852557,
-0.008110388,
-0.008274168,
0.02551038,
0.027462637,
-0.008948942,
-0.008503459,
-0.028851492,
-0.006767391,
0.0043074153,
-0.0037571143,
0.042006306,
0.039831307,
0.01646972,
-0.0035605782,
0.027410228,
0.009086517,
-0.022313394,
-0.0009073414,
-0.0239905,
0.008962044,
-0.009853007,
0.0004160013,
-0.0047299676,
-0.0114515005,
0.015198788,
0.010809483,
-0.012362118,
0.0153429145,
0.025392458,
0.013416861,
0.0013339885,
0.007540433,
0.0007894198,
0.0016549974,
-0.01521189,
0.010285387,
0.0047856527,
-0.022287188,
0.02927077,
-0.030266551,
-0.007697662,
-0.0030708758,
0.010160914,
0.0060009006,
-0.014871228,
-0.013429964,
-0.017910985,
-0.0207149,
-0.0142685175,
-0.020334931,
-0.0066920524,
0.0032952544,
-0.008968595,
-0.025680711,
0.019037792,
-0.018526798,
-0.04677558,
-0.00241248,
0.025772428,
-0.007763174,
-0.036398478,
-0.00523441,
0.010730868,
0.02911354,
0.017006919,
-0.016849691,
-0.011385988,
0.036922574,
0.012021455,
-0.03183884,
0.015500143,
-0.0143340295,
0.011032224,
0.016666258,
0.008444499,
0.0034983417,
-0.017439298,
0.012938623,
0.023728453,
-0.006721533,
-0.030738238,
0.0042320765,
-0.021238996,
0.012781395,
0.0004045367,
0.0027351268,
-0.010698113,
-0.0124538345,
0.0021733611,
-0.027593661,
-0.034092452,
-0.016744873,
-0.010534332,
-0.010154363,
-0.014530566,
0.0055685216,
-0.02005978,
-0.022274086,
0.010612947,
-0.026912337,
0.011333579,
-0.00823486,
0.014753306,
0.018238546,
-0.013652705,
0.012624166,
0.0033443884,
-0.024881463,
-0.013547885,
-0.01237522,
0.034092452,
0.010108504,
-0.025995169,
-0.011281169,
-0.018736437,
0.0009818614,
-0.02628342,
-0.018592311,
0.0022667157,
0.035638537,
-0.018015806,
-0.0016148712,
-0.0045661875,
-0.01717725,
0.0036588463,
0.017897883,
-0.006089342,
-0.00297097,
-0.0070949513,
0.008261065,
-0.004972362,
-0.0207149,
0.009152029,
-0.034852393,
-0.019142611,
0.029244564,
0.017793063,
0.00539819,
-0.001230807,
0.010789829,
-0.003956926,
-0.010534332,
0.0027138353,
-0.017478606,
-0.006950825,
-0.03118372,
0.044128895,
0.041770462,
0.02649306,
-0.0057978136,
-0.003259223,
0.033777997,
0.0013896737,
0.002797363,
-0.0065217214,
0.020400442,
-0.007867993,
0.033149082,
0.003504893,
0.0014388077,
-0.0008078451,
-0.008699995,
0.007992466,
0.024409778,
-0.01455677,
-0.010947058,
-0.004055194,
-0.037918355,
-0.03233673,
-0.014150595,
0.0044155098,
-0.006561029,
-0.037315644,
-0.003897965,
-0.0046153218,
-0.013534782,
-0.008811367,
0.027121976,
0.035245467,
-0.019548787,
0.0013020514,
-0.019692913,
0.02261475,
-0.0056307577,
-0.0013249805,
-0.009938173,
-0.0058502234,
-0.003986406,
-0.005424395,
0.043578595,
0.018107522,
-0.0008008844,
0.0022208574,
0.0064136265,
-0.028668059,
-0.012827253,
0.0024010155,
-0.041770462,
-0.009787495,
-0.010730868,
-0.008726201,
-0.008817918,
-0.0028645128,
-0.0033329239,
-0.008745855,
0.011562871,
-0.014530566,
-0.003504893,
0.0075535355,
-0.005178725,
0.017216558,
-0.010914302,
0.02895631,
0.047194857,
-0.0039995085,
-0.031026492,
-0.016967613,
-0.0076387012,
0.0025435041,
0.03637227,
0.016338697,
-0.013416861,
-0.03521926,
0.0021537077,
-0.0007255456,
-0.020531466,
-0.033542152,
0.00016285878,
0.004160013,
-0.0020800065,
-0.018002702,
-0.0032608607,
-0.019247431,
0.009898866,
-0.011831471,
0.024304958,
0.006341563,
-0.0045268806,
0.0017409818,
0.032520164,
-0.011104287,
0.0041239816,
-0.007920403,
-0.0019031242,
-0.008510011,
-0.015775293,
-0.011438399,
-0.0003040167,
0.002011219,
0.022876797,
-0.020701798,
-0.0045563607,
-0.00037976497,
-0.011019121,
-0.0033705933,
0.006459485,
0.0068329033,
0.039385825,
-0.010881546,
-0.0024829055,
0.014831921,
0.0061253738,
-0.009256848,
-0.017504811,
-0.014032674,
-0.0146746915,
-0.027462637,
-0.017373787,
0.020295624,
0.009715432,
0.015421529,
0.0012987758,
-0.016220776,
-0.021016255,
-0.024815952,
-0.03173402,
0.010940507,
-0.028432215,
0.0021209517,
0.019837039,
0.012597961,
0.009682676,
-0.010770176,
-0.00035089874,
0.0068263523,
0.041770462,
-0.0034459322,
0.018173033,
0.0023355035,
0.0017229661,
-0.02644065,
0.0051426934,
-0.008975146,
-0.024160832,
-0.016692461,
-0.021841707,
-0.03173402,
0.00004212218,
-0.0077435207,
0.01929984,
0.0023780863,
-0.007396307,
-0.0100364415,
0.022981616,
0.030397575,
-0.005571797,
0.0045367074,
-0.0071277074,
-0.027986733,
-0.011484257,
0.0063481145,
-0.003160955,
0.0012029645,
-0.022339597,
-0.0033509396,
0.0023436924,
-0.013940957,
-0.0040486427,
-0.0084969085,
0.008889981,
-0.0019031242,
0.0061679566,
-0.022706466,
-0.017662039,
-0.015722884,
0.0016214225,
0.0068263523,
-0.015552553,
-0.033306308,
0.010599844,
0.013678909,
0.005932113,
-0.027410228,
0.003472137,
-0.012060762,
-0.026034476,
-0.033332516,
0.00795971,
-0.030449986,
0.029899685,
0.018290956,
0.0064791385,
-0.033306308,
0.018435081,
-0.05707407,
-0.0534316,
0.002042337,
0.013521681,
0.0059779715,
0.015644269,
-0.00021885108,
-0.010979814,
0.0046349755,
0.0061646807,
-0.010881546,
-0.014635385,
0.018762643,
-0.02338779,
0.017924087,
0.020033576,
-0.022143062,
-0.016378004,
0.028170167,
0.0015174221,
-0.011300823,
0.021579659,
0.004343447,
0.066927075,
-0.022929206,
0.03854727,
0.030004503,
0.0067935963,
0.020334931,
-0.01760963,
-0.02218237,
0.0070621953,
-0.025484174,
0.0015313434,
-0.007979364,
0.00043565492,
-0.011562871,
0.002379724,
-0.0019293289,
0.0017000368,
0.013416861,
0.01662695,
0.0023273143,
-0.009204439,
-0.0038357286,
0.017295172,
-0.008542767,
-0.0020865577,
-0.0121852355,
0.017950293,
0.009735086,
0.0057323016,
-0.0010768538,
0.004605495,
-0.010514678,
-0.008660689,
-0.0048151333,
-0.026519265,
-0.013482373,
-0.017255865,
-0.012178684,
-0.023872579,
0.04203251,
0.0039831307,
0.000008112231,
-0.0033607665,
-0.021304509,
-0.0060467594,
-0.03147197,
0.008483807,
-0.01717725,
-0.01831716,
-0.0025729844,
0.010350899,
0.00022642591,
-0.012886214,
0.008955493,
0.012001801,
0.0062301927,
0.006095893,
0.17651558,
0.00471359,
0.017216558,
0.043080702,
0.022012038,
-0.010010236,
0.024986284,
0.0005711829,
-0.0049690865,
0.022640953,
0.01831716,
0.006747738,
-0.0074552675,
0.0018097694,
0.029375589,
-0.007664906,
-0.005021496,
-0.025864145,
-0.008988249,
-0.016456619,
0.018173033,
-0.03309667,
0.014412643,
-0.0022667157,
0.0007517504,
0.003357491,
-0.008785161,
-0.00029521354,
0.018225443,
0.018304057,
-0.016050445,
0.018408878,
0.0065544774,
0.0035671294,
-0.0019326045,
-0.012565205,
0.0028694263,
-0.005951767,
0.017268967,
-0.027436433,
-0.008523113,
0.0011235311,
0.0077828276,
0.011569423,
0.002618843,
0.025444867,
-0.0018539901,
0.02197273,
0.022378905,
0.0117200995,
-0.02666339,
0.027881915,
-0.0006268681,
0.010783278,
-0.0102395285,
-0.0009556566,
0.0107112145,
-0.010999468,
0.0010776727,
0.014923638,
-0.015631167,
0.009807149,
-0.008582074,
0.028143963,
-0.021959629,
0.02420014,
-0.008686894,
-0.018290956,
-0.0018736437,
-0.018068215,
-0.020544568,
-0.004464644,
-0.016443517,
0.009551652,
-0.005424395,
-0.019823937,
0.050522868,
0.022798182,
0.029349383,
-0.0041665644,
0.0032952544,
0.0010850428,
-0.031288538,
-0.0073242434,
0.0038684846,
-0.027226795,
0.041953895,
0.0035081685,
-0.032231912,
-0.020898333,
0.0006981124,
0.020243213,
0.0028153788,
-0.02252303,
-0.016653154,
0.0014838472,
0.016115956,
0.0158146,
-0.010160914,
-0.014163698,
-0.03768251,
0.07211563,
0.0059452155,
-0.0004950252,
-0.004703763,
0.029061131,
-0.0016156902,
0.010639152,
-0.039805103,
0.012709332,
0.006787045,
-0.026859928,
-0.006341563,
-0.010350899,
-0.0070949513,
0.03700119,
0.023374688,
-0.0196274,
0.042818654,
0.014281619,
0.0019211399,
-0.017465504,
0.008739303,
0.014648487,
0.0012496418,
-0.026558572,
-0.0058502234,
0.017858576,
-0.009715432,
-0.013482373,
-0.030161733,
-0.015840806,
-0.0012488228,
0.0087655075,
-0.012650371,
-0.008470704,
0.0094337305,
-0.0012398149,
-0.024776645,
-0.0030708758,
-0.0036064365,
-0.013796831,
-0.0035769562,
-0.01058019,
0.015303607,
-0.0023617083,
0.024776645,
0.032022275,
0.005958318,
-0.031000286,
0.0018769193,
-0.028589444,
-0.0016590918,
-0.0063251853,
0.019404659,
0.001970274,
-0.0019997542,
-0.02861565,
-0.01738689,
0.023531917,
-0.022326495,
0.038809318,
0.0007951521,
0.005080457,
-0.0142030055,
-0.015146378,
-0.16372764,
0.0052540638,
0.035402693,
-0.005463702,
0.02442288,
0.016168365,
0.001485485,
-0.025523482,
0.0063317367,
-0.0078090327,
0.030974083,
0.008975146,
-0.050365638,
-0.023728453,
0.017779961,
0.013115506,
-0.01814683,
0.031445768,
0.008713098,
0.0009212627,
0.038023174,
-0.009263399,
-0.010855341,
-0.011241863,
0.01662695,
-0.015395324,
-0.006420178,
-0.0113794375,
0.0024075666,
-0.037079804,
-0.011202555,
0.0015706506,
0.024187038,
0.016063547,
0.0011251689,
-0.0028972689,
0.0042975885,
-0.021291405,
0.0077042133,
0.014753306,
0.03875691,
0.03466896,
0.002921836,
-0.011333579,
0.025274536,
0.01329894,
-0.0076845596,
-0.026794415,
0.030318962,
-0.012263849,
0.027279204,
0.018173033,
-0.01177251,
0.009990582,
0.025484174,
-0.0012037833,
0.021356918,
-0.0049363305,
-0.00012170905,
0.008477255,
-0.011464603,
-0.011739753,
0.015683576,
-0.019706015,
0.012034558,
-0.029349383,
0.008385538,
0.0117856115,
-0.016784178,
0.0069311713,
-0.007363551,
0.0051230397,
0.006335012,
-0.019719116,
0.035769563,
0.013862343,
0.0007787741,
0.012892765,
-0.0027056462,
0.010219875,
-0.034380708,
0.018998485,
-0.036162633,
-0.013456169,
0.0014044138,
0.0007312779,
0.01885436,
-0.0084969085,
-0.006636367,
0.0032346558,
0.008431396,
-0.017478606,
0.0063710436,
-0.015002252,
0.03280842,
0.012041109,
-0.02093764,
-0.014386439,
-0.009086517,
-0.019483274,
0.011543217,
-0.0099709295,
-0.018186135,
-0.0057519553,
0.034380708,
-0.009040658,
-0.015552553,
0.003455759,
0.04394546,
-0.017963395,
0.00536871,
0.0035409245,
0.0110453265,
0.037027393,
-0.007592843,
0.033935227,
0.0028333948,
0.009191336,
0.018068215,
-0.044469558,
0.055082504,
-0.0051230397,
-0.0076845596,
0.03466896,
0.023374688,
0.0076387012,
-0.12735537,
-0.010042992,
-0.0003676862,
0.028982516,
-0.007926954,
0.015801499,
0.0035507514,
0.019810835,
-0.0036195389,
0.031419564,
0.015709782,
-0.040198173,
0.016653154,
-0.01106498,
0.0046906606,
-0.016443517,
0.012349015,
-0.012034558,
-0.014687794,
0.025588995,
0.017426196,
0.002617205,
-0.0037047046,
-0.014727102,
0.018500594,
0.01978463,
-0.037865944,
0.022169266,
0.01493674,
0.030974083,
0.008844122,
-0.014006469,
0.013253081,
-0.006950825,
-0.028537035,
0.014871228,
-0.015093969,
-0.041456003,
0.037210826,
0.012014904,
-0.0036457437,
-0.0036457437,
0.0033132702,
0.0040682964,
-0.0033935225,
-0.01771445,
-0.006639643,
-0.009060312,
0.0009826802,
-0.03296565,
-0.035009623,
-0.017360685,
0.0008688531,
0.0047856527,
0.0026810793,
-0.008916185,
0.014163698,
-0.0042812102,
0.0035671294,
-0.008044876,
-0.010187118,
-0.0072849365,
-0.028982516,
0.004530156,
0.018251648,
-0.015041559,
-0.027515048,
-0.037106007,
0.019365352,
-0.024003603,
-0.0010113418,
0.018893667,
-0.01624698,
-0.00020032347,
-0.015107071,
0.009171682,
-0.015185686,
-0.004638251,
0.0019850142,
-0.011137043,
0.008516562,
-0.011936289,
0.02628342,
-0.011982148,
0.017910985,
-0.0053457804,
0.016391106,
0.0013094215,
-0.0065217214,
0.005290095,
0.0014027761,
0.035350285,
0.0017393441,
-0.028537035,
-0.0061352006,
0.0045923926,
0.011523563,
-0.020308726,
0.03173402,
0.019719116,
-0.0020832822,
-0.0137313185,
-0.054558408,
0.018985383,
0.0057519553,
0.0075142286,
-0.009676125,
-0.00888343,
0.016220776,
-0.021383122,
-0.000029838677,
-0.01155632,
-0.024134627,
-0.0045989435,
-0.018684028,
0.008791713,
-0.036765344,
-0.012768292,
0.01995496,
0.011530115,
-0.0013651067,
0.014923638,
-0.00061581295,
-0.0073045897,
0.0133972075,
0.009558204,
-0.014045777,
0.005178725,
-0.027567457,
0.026414445,
-0.007900749,
-0.009099619,
-0.008942391,
-0.026807517,
-0.023898784,
0.0076190475,
-0.0136002945,
-0.024907669,
0.034852393,
0.023020923,
0.026794415,
0.026466856,
-0.006426729,
-0.02693854,
0.011412193,
0.012296606,
-0.002035786,
0.015618065,
-0.03839004,
0.009269951,
0.006452934,
0.0011399091,
0.034433115,
0.013443066,
0.019915653,
-0.016155263,
0.00033943413,
-0.008130041,
-0.004572739,
0.010789829,
0.0012619252,
-0.028432215,
0.013482373,
0.017124841,
0.007900749,
-0.0028088277,
-0.008863776,
-0.016495926,
-0.025261434,
0.0050509768,
-0.005958318,
-0.022418212,
-0.02000737,
0.00932236,
0.025038693,
0.014517463,
0.019116407,
-0.020898333,
0.0007181755,
0.0015059575,
-0.022994718,
0.022103755,
0.0048544407,
0.009761291,
-0.0047561727,
0.0147402035,
0.042451788,
-0.003177333,
-0.01569668,
0.038337633,
0.0015534537,
0.0163518,
0.0076387012,
0.025418663,
0.01821234,
0.0034590345,
0.006017279,
0.01199525,
-0.0078090327,
0.010023339,
0.015500143,
0.024842156,
-0.009944724,
-0.005270442,
0.018828154,
-0.05146624,
-0.019090202,
0.002987348,
-0.04344757,
-0.03118372,
0.0031200098,
0.006190886,
0.0065020677,
0.023689145,
-0.0035507514,
0.0023518815,
-0.0019964788,
0.0062170904,
0.023885682,
-0.013069647,
-0.008516562,
0.028930107,
0.0051099374,
0.01597183,
0.0112484135,
0.01079638,
-0.0061679566,
-0.003406625,
0.018526798,
-0.040905703,
0.02932318,
-0.0018736437,
0.03139336,
0.0063710436,
-0.024501495,
-0.012519347,
-0.006181059,
-0.032153297,
-0.011680793,
0.029952094,
-0.01978463,
0.080448754,
0.032834623,
-0.0066855014,
-0.0035081685,
-0.022365803,
0.011975597,
0.02066249,
0.016220776,
-0.022287188,
-0.0017753757,
0.024593212,
-0.03123613,
0.018736437,
-0.027777096,
-0.018002702,
0.021252098,
-0.03058101,
0.005227859,
-0.022811284,
-0.02621791,
0.03996233,
-0.018566106,
0.01574909,
0.020950744,
-0.014858126,
-0.013416861,
0.018631618,
-0.019837039,
0.019417763,
0.010678459,
0.021789297,
0.00959751,
-0.05607829,
0.007730418,
0.0045989435,
0.005499734,
0.0033476641,
-0.039595462,
0.014451951,
0.013036892,
-0.012126274,
-0.0058272937,
-0.013940957,
-0.002150432,
-0.0035573025,
-0.016535234,
-0.031812634,
-0.0042746593,
-0.006852557
] |
Ex-FABP, an extracellular fatty acid binding lipocalin, is physiologically expressed by differentiating chicken chondrocytes and myoblasts. Its expression is enhanced after cell treatment with inflammatory stimuli and repressed by anti-inflammatory agents, behaving as an acute phase protein. Chicken liver fragments in culture show enhanced protein expression after bacterial endotoxin treatment. To investigate the biological role of Ex-FABP, we stably transfected proliferating chondrocytes with an expression vector carrying antisense oriented Ex-FABP cDNA. We observed a dramatic loss of cell viability and a strong inhibition of cell | [
-0.030370776,
-0.0035746135,
-0.016824873,
-0.036740575,
-0.03268218,
-0.016690489,
-0.03510109,
0.0075322213,
-0.0065344204,
-0.0019216907,
0.0125649,
0.0068603014,
0.0016520829,
0.02765622,
-0.008654327,
0.00078824593,
0.02707837,
0.0063832384,
-0.021192351,
0.013505588,
-0.01122778,
0.0140834395,
0.00029543476,
-0.026769286,
-0.011321849,
-0.0070954734,
0.0020392768,
-0.047303155,
-0.015803555,
-0.032037135,
0.0020762323,
-0.008083195,
-0.021823956,
0.03058579,
0.0052577727,
-0.014741921,
-0.0100183245,
-0.021837395,
0.0253045,
0.0160992,
0.03754688,
-0.0006777991,
0.00093564834,
0.019969458,
0.010535703,
-0.020869829,
0.0053585605,
-0.0013346007,
-0.008943253,
0.013962494,
0.031526476,
0.0040483167,
-0.010132551,
-0.020910146,
-0.019257221,
-0.0017940259,
0.0036418054,
0.0076733246,
-0.0025280984,
-0.009823468,
-0.003678761,
0.011906419,
-0.02421599,
-0.0022425323,
0.017617738,
0.027602466,
-0.009648768,
0.026030174,
0.007592694,
-0.0026171277,
0.020990776,
0.014822551,
-0.014190947,
-0.009823468,
0.029295703,
-0.013814672,
-0.02480728,
0.0007172744,
-0.0022996457,
0.008902937,
0.026500518,
-0.02154175,
0.0045724143,
0.03074705,
0.01952599,
-0.008419155,
0.0024407487,
0.022804959,
0.01366685,
0.0003470886,
0.027306821,
0.03168774,
0.012699285,
0.017967137,
-0.03410665,
-0.002338281,
0.011442794,
0.022025531,
-0.0067830305,
-0.028811922,
-0.009729399,
0.00603384,
-0.014379084,
-0.018047767,
-0.021514872,
0.0037593914,
0.010717121,
-0.020574184,
0.017940259,
-0.008869342,
-0.02471321,
0.054022353,
0.0066587254,
-0.0430835,
0.020453239,
-0.022670574,
0.0042095776,
-0.025412008,
-0.0062958887,
-0.0056441263,
0.0036082095,
0.04534115,
0.01282023,
0.003994563,
-0.0017369128,
-0.0048814975,
-0.0059128944,
-0.007948811,
-0.022186792,
0.00536528,
0.012753038,
0.01869281,
0.008580416,
0.004098711,
-0.026043613,
0.0030992301,
-0.041067738,
-0.014903181,
-0.026594587,
-0.032064013,
0.008157107,
0.029026937,
-0.0022946063,
0.019337852,
-0.011247938,
0.027508397,
0.023705332,
0.022159915,
-0.0035040618,
0.0013026845,
0.012007208,
-0.02773685,
0.01416407,
0.0083586825,
-0.007895058,
-0.0048982953,
-0.009144829,
0.015158511,
-0.009440473,
-0.031445846,
-0.00796225,
-0.011671247,
0.016945818,
0.00779427,
0.028892552,
0.02236149,
0.003394875,
-0.010932135,
0.008734957,
-0.00821086,
0.0020896706,
0.007592694,
-0.023396248,
0.008761834,
-0.0036014903,
0.01960662,
-0.0026423247,
0.0015949697,
-0.006685602,
-0.029806362,
-0.012013926,
0.016784556,
0.029403212,
-0.010361004,
0.001960326,
-0.0075322213,
0.037842523,
-0.043137252,
-0.004374198,
-0.018880947,
-0.005288009,
0.013626534,
0.0095614195,
-0.023450002,
-0.6398827,
-0.023987537,
0.023785962,
-0.00838556,
0.011174027,
0.030773928,
0.0050797137,
-0.018988455,
-0.02480728,
0.018195588,
-0.012128153,
0.008674485,
0.011288253,
-0.006796469,
-0.0005413154,
-0.023369372,
-0.0080966335,
-0.018249342,
0.02195834,
0.012430517,
-0.007935373,
-0.014217824,
-0.013243539,
0.03343473,
0.008446032,
0.033461608,
0.01659642,
-0.015763238,
-0.0003981125,
0.017147394,
-0.019176591,
0.05579622,
0.0062622926,
0.0012489309,
0.061977886,
0.0088290265,
-0.00678975,
0.002865738,
0.0131293135,
0.0150644425,
0.006279091,
-0.006695681,
0.00068577816,
-0.001935129,
-0.035692383,
0.033058453,
0.018249342,
0.024780404,
-0.0044850647,
0.000720634,
0.010885101,
0.008587135,
-0.035181724,
-0.005922973,
0.00087601546,
0.0010843106,
0.013330889,
-0.025035733,
0.0029110927,
0.008432594,
0.028462524,
0.028758168,
-0.017832752,
-0.01927066,
-0.013545903,
0.00980331,
-0.010105674,
-0.0047907885,
0.01147639,
-0.004851261,
0.022939343,
0.028623784,
-0.001315283,
0.010320689,
0.011113554,
0.016314214,
-0.0035880518,
0.005892737,
-0.013566061,
0.014002809,
0.013371204,
0.0077741123,
-0.024578827,
0.0112076225,
0.004575774,
0.0112210605,
-0.035719257,
0.0159245,
-0.0029598067,
-0.021823956,
0.0058221854,
0.004182701,
-0.022885589,
-0.03383788,
-0.030639544,
0.008708081,
-0.009769714,
-0.0039038542,
0.00019464677,
-0.006588174,
-0.016220145,
0.011194184,
0.018786877,
-0.005388797,
0.01886751,
-0.009601735,
-0.018034328,
0.0159245,
0.029241951,
-0.039831407,
0.008889499,
-0.009359843,
-0.002724635,
-0.033380978,
-0.005146906,
-0.0222943,
0.01499725,
0.00091297104,
-0.006678883,
-0.035961147,
0.011698124,
-0.00821086,
0.008533382,
0.008150388,
0.011422637,
0.027548712,
-0.016367966,
-0.011778754,
-0.012558182,
-0.0000013943649,
0.017953698,
-0.006252214,
0.033327222,
-0.025358254,
0.03536986,
0.026245188,
0.027185876,
0.025949543,
0.01215503,
-0.04617433,
-0.01970069,
-0.0022240547,
0.018746562,
-0.0016546026,
-0.00779427,
-0.003510781,
0.0074515906,
0.0172549,
0.017631177,
0.039428256,
0.0012287734,
0.008284772,
0.0018897745,
0.0008205821,
0.026608026,
-0.008472909,
0.009695803,
-0.014311892,
-0.0054089543,
-0.009655488,
-0.008372121,
-0.0039744056,
0.009910817,
-0.0037224358,
0.0020224787,
-0.0041659027,
0.020171033,
0.006840144,
0.00065890135,
-0.015225703,
-0.003493983,
-0.022563068,
-0.013760918,
0.005805387,
-0.0046564043,
0.008889499,
0.009984729,
-0.000060472783,
0.010414757,
-0.013095717,
0.0206145,
-0.008157107,
0.00091213116,
0.003897135,
0.04894264,
0.014795674,
0.0056206095,
0.0063429233,
-0.014930058,
0.021272982,
-0.011153869,
0.004300287,
-0.013209944,
0.026473641,
0.011106835,
-0.013606376,
0.002052715,
0.0155079095,
0.028973183,
0.010300531,
-0.00026624821,
-0.01651579,
0.009816749,
-0.013801233,
0.011812351,
-0.030128885,
-0.018383726,
-0.01390874,
0.014594099,
-0.009151548,
-0.0048882165,
0.023933783,
-0.010233339,
0.0047571925,
-0.014446276,
-0.012383482,
0.015978253,
-0.028086249,
0.0070618773,
0.010844786,
-0.0010288772,
-0.0012119754,
0.00854682,
-0.004387636,
-0.016824873,
0.008802149,
-0.0076397285,
0.024457881,
-0.016569544,
-0.010885101,
0.0030639544,
0.014889743,
0.015682608,
0.009185144,
0.0076397285,
-0.016273897,
0.0042465334,
-0.012625373,
0.052221607,
0.0063227657,
0.0025801721,
0.023167795,
0.018719686,
0.005455989,
-0.015158511,
-0.023880031,
-0.0061379876,
0.01558854,
0.0051133097,
-0.011832508,
-0.010757436,
0.019714128,
-0.01869281,
0.0017570703,
-0.009332966,
0.00829149,
-0.010952293,
0.0059095346,
0.043137252,
0.0010666727,
0.01617983,
0.024766965,
-0.0064504305,
-0.0023584387,
0.025492638,
0.018222466,
-0.0066587254,
-0.03109645,
-0.03217152,
0.008647608,
-0.012672408,
0.0049654874,
0.0085938545,
-0.03886384,
-0.0030488363,
0.005973367,
0.029698856,
0.0140834395,
0.021743326,
-0.004474986,
-0.010327408,
-0.040745217,
0.012719442,
0.017550545,
-0.007075316,
0.00060388795,
-0.041632153,
0.003947529,
-0.005214098,
-0.0009994807,
-0.0019519271,
-0.00009496117,
0.02144768,
0.0072903302,
-0.016703926,
0.013552623,
0.012343167,
-0.022468999,
0.031875875,
-0.02690367,
-0.0054996638,
-0.01869281,
-0.0038870561,
-0.012941176,
0.031822123,
0.01617983,
0.006084234,
0.010683525,
0.009366563,
-0.020090403,
0.0039508888,
-0.005237615,
-0.0017058364,
-0.005882658,
0.020171033,
0.0052241767,
-0.015118196,
0.002311404,
0.03133834,
-0.014889743,
-0.01366685,
-0.026796162,
-0.0016688808,
-0.011664528,
0.0159245,
0.008412437,
-0.0016193268,
-0.000107612155,
-0.0030488363,
0.011160588,
-0.007310488,
-0.021272982,
0.009601735,
-0.0058625005,
-0.008446032,
-0.016945818,
0.0019687251,
-0.0040483167,
-0.0102669345,
0.008493067,
-0.006830065,
-0.03252092,
-0.011167307,
0.0019317694,
0.0044212323,
-0.0018914543,
0.013841548,
0.029806362,
0.020842953,
0.0030555553,
-0.005288009,
0.03838006,
-0.0047538327,
-0.019552866,
0.0075725364,
0.003033718,
0.0024189113,
0.0053988756,
0.022643698,
-0.026943985,
-0.001567253,
0.009138109,
0.004817665,
0.037654385,
0.0034402295,
0.020251663,
0.019620059,
-0.0046362467,
-0.00095832563,
-0.008036161,
-0.003134506,
-0.00063328445,
0.0041625435,
-0.021246105,
0.040261436,
-0.006987966,
-0.013122594,
-0.01332417,
0.0020409564,
-0.029188197,
-0.0077203587,
0.0035880518,
0.0060204016,
-0.010461791,
-0.004256612,
-0.018477796,
0.0027867875,
-0.0029967623,
-0.00427341,
-0.010300531,
-0.017362408,
-0.017671492,
0.0033243233,
-0.012128153,
0.0019922422,
-0.02757559,
-0.004817665,
0.000038845366,
0.0048982953,
0.014311892,
0.013653411,
-0.0054660677,
-0.0070081237,
0.024686335,
-0.008143668,
-0.0020325575,
-0.016247021,
-0.05071651,
-0.0055534174,
0.0077270777,
0.018827192,
-0.030451406,
-0.015709486,
-0.016475474,
0.02707837,
-0.012383482,
0.019727565,
-0.002195498,
-0.016986134,
-0.00019055227,
0.024417566,
0.008607293,
0.023826277,
0.00042204963,
-0.007256734,
-0.024014415,
-0.0038097855,
-0.021944901,
-0.0060976725,
0.019821635,
0.0072365766,
-0.0048915762,
-0.017187709,
-0.013183067,
0.0069610896,
0.004616089,
-0.018410603,
0.0004113409,
0.0013052042,
0.04418545,
0.0038937754,
0.012840387,
0.01658298,
-0.0016394843,
-0.008143668,
-0.017133955,
0.0083586825,
-0.019149715,
-0.020318855,
0.0035678942,
-0.0070618773,
-0.02564046,
-0.021528311,
-0.004817665,
-0.016314214,
0.025882352,
-0.011422637,
-0.024457881,
-0.058000118,
0.0037929874,
-0.0029816441,
0.0068569416,
-0.000010387198,
-0.011530144,
-0.027279945,
-0.010421476,
0.014903181,
-0.01677112,
0.024377251,
-0.032547794,
-0.00048714186,
0.006947651,
-0.0005669324,
0.0048714187,
0.007075316,
0.000996961,
-0.018921262,
0.006006963,
-0.03026327,
-0.020910146,
0.014782236,
-0.0033545597,
0.033300348,
0.011422637,
0.03227903,
0.010038482,
0.016394844,
0.015548225,
-0.004710158,
0.017456478,
0.0031042695,
-0.00034960828,
0.00012923958,
0.024081606,
0.027521836,
-0.003796347,
0.01894814,
-0.020789199,
-0.010623053,
0.032574672,
-0.016448596,
-0.021004213,
0.006235416,
0.0037862682,
-0.042142812,
0.008110072,
-0.0035443772,
0.019579744,
-0.041309632,
-0.01382811,
0.002363478,
0.0066654445,
0.007048439,
-0.023920346,
0.035719257,
-0.03502046,
0.030155761,
-0.0028203835,
-0.022012094,
-0.0038165045,
-0.015790116,
0.016112637,
-0.015400402,
0.019324414,
-0.009749557,
0.011993769,
0.0008121831,
-0.00971596,
-0.018571863,
-0.012410359,
-0.0053854375,
-0.009339686,
-0.024619142,
-0.003218496,
-0.02221367,
-0.0206145,
-0.0066923215,
-0.042169686,
-0.0014194306,
0.015857307,
-0.01677112,
0.033891637,
0.014096878,
-0.00762629,
0.039750777,
-0.020036649,
0.02832814,
-0.026245188,
0.03244029,
0.021608941,
0.007182823,
-0.01970069,
-0.009957852,
0.0041625435,
0.015279457,
0.05179158,
0.01861218,
0.0000061844185,
-0.018383726,
-0.013041964,
0.041659027,
-0.007968969,
-0.013371204,
0.031015819,
-0.017805874,
-0.0014538665,
-0.009151548,
-0.007921935,
-0.017416162,
-0.0049923644,
-0.007465029,
-0.0018410604,
0.011301692,
-0.013048683,
-0.028086249,
0.014298454,
-0.0013077239,
0.018061204,
-0.001483263,
-0.004458188,
-0.017859628,
-0.020439802,
0.016959256,
0.006195101,
0.0037694701,
0.012269256,
0.008519943,
0.016220145,
0.03117708,
0.014594099,
0.0013455194,
-0.0037593914,
0.012618654,
0.029564472,
0.002119907,
0.000059527898,
0.0043103658,
0.014311892,
0.025102925,
-0.018061204,
-0.00854682,
-0.024538511,
-0.018988455,
0.0023567588,
0.031741492,
0.008056318,
-0.049560808,
0.00209471,
-0.027709974,
0.0074717486,
-0.018007452,
-0.020090403,
0.0026137682,
-0.03781565,
-0.01659642,
-0.0073642414,
0.007848023,
-0.002781748,
0.010112394,
0.0045220205,
-0.007942093,
0.019593181,
-0.025519514,
0.037143726,
-0.016542666,
0.0076061324,
-0.036444932,
0.015951376,
-0.02506261,
0.0019032129,
-0.009413596,
-0.023369372,
0.007525502,
-0.01282023,
0.0034049537,
0.02546576,
0.024820719,
-0.0005396356,
0.03426791,
-0.018961577,
0.01148311,
0.004515301,
0.0072029806,
-0.0019233705,
-0.0012405319,
0.0015051004,
0.006269012,
0.00032945068,
-0.010992608,
-0.0068199863,
-0.015696047,
0.017644614,
0.008056318,
-0.013566061,
-0.003796347,
0.022186792,
-0.03201026,
-0.013384643,
-0.021178912,
-0.006722558,
-0.00854682,
0.019297536,
0.014338769,
-0.0021753404,
-0.0028153441,
-0.0055030235,
-0.0021165474,
0.007431433,
-0.017617738,
-0.008318367,
-0.021676134,
-0.02723963,
0.011180745,
0.024041291,
-0.034052897,
0.04023456,
-0.010401319,
-0.0299945,
-0.018114958,
0.01709364,
-0.034993585,
0.0012682487,
-0.026003297,
-0.0013539185,
-0.02221367,
-0.0040348787,
-0.0081235105,
0.00862745,
-0.004387636,
0.018289657,
0.015131635,
-0.004115509,
0.010589456,
-0.020856392,
0.023974098,
0.008036161,
-0.022818398,
-0.036471806,
0.030075131,
0.017107079,
-0.0025196993,
0.023140918,
-0.018168712,
0.012208783,
-0.02228086,
0.02757559,
0.00234668,
0.017994013,
0.024847595,
-0.03988516,
0.009863783,
0.012497708,
0.0017671491,
0.00004850421,
0.0051099504,
0.0095479805,
0.001777228,
0.00044472693,
-0.0021333455,
-0.02682304,
0.0026372853,
0.004659764,
0.022482438,
-0.0038333025,
-0.0012749679,
0.0051166695,
0.021313297,
-0.03351536,
-0.017711807,
-0.0112210605,
-0.023087164,
-0.008009284,
0.0017856269,
0.011126992,
-0.014365646,
-0.0009003726,
0.00004986905,
-0.020668253,
-0.0044380305,
-0.017725244,
0.0036518842,
0.004139026,
0.01215503,
-0.0063059675,
-0.02027854,
-0.0333541,
0.0051133097,
-0.0047202366,
-0.013062121,
-0.0075322213,
0.004884857,
-0.012013926,
-0.008842465,
0.019673813,
-0.011449514,
-0.008116791,
-0.0100183245,
-0.020506993,
0.02781748,
0.036633067,
0.18018202,
-0.011100115,
0.006594893,
-0.014446276,
-0.014930058,
0.012202064,
-0.021057967,
0.008419155,
-0.0097831525,
0.012753038,
0.032144643,
0.0019317694,
-0.003779549,
-0.0012464112,
-0.0066822427,
0.009581577,
-0.0160992,
0.0102534965,
-0.011032923,
-0.030693298,
0.01139576,
-0.01382811,
0.020412924,
0.0072903302,
0.028946307,
0.005681082,
-0.021111721,
-0.013055402,
0.00095244637,
0.012558182,
-0.005288009,
-0.003577973,
-0.009991447,
0.0028052651,
0.008808869,
0.021501435,
-0.0061312686,
0.00045648552,
0.012128153,
0.0059968843,
0.022684013,
-0.0067024003,
0.01148311,
-0.014661291,
-0.0007029961,
-0.018303096,
0.0036384459,
-0.015548225,
-0.0057012397,
0.013162909,
-0.05254413,
-0.011449514,
0.008506505,
0.021125158,
0.012914299,
-0.00343687,
0.0064907456,
0.025183555,
-0.008607293,
0.013471993,
0.00095244637,
0.008869342,
-0.032305904,
0.0070417197,
-0.038084414,
0.014849428,
0.005382078,
-0.030102007,
0.0116914045,
-0.01616639,
0.029510718,
0.00611783,
-0.0098100295,
-0.006484026,
-0.006746075,
-0.026876792,
0.010858225,
0.0062589333,
0.017416162,
0.03980453,
0.011866104,
0.0050662756,
-0.04526052,
0.015454155,
-0.031150203,
-0.02253619,
0.015266018,
-0.00048210248,
-0.026876792,
-0.031983383,
0.024256306,
-0.023167795,
-0.017859628,
-0.00064000365,
0.0222943,
-0.01927066,
-0.0015059403,
-0.005170423,
-0.02488791,
-0.017886506,
-0.031230833,
0.06772952,
0.0002538597,
0.017214585,
-0.012531305,
-0.01600513,
-0.019310975,
0.012215503,
-0.0075187827,
-0.009910817,
0.009736118,
-0.01642172,
-0.011194184,
-0.036176164,
0.0067427154,
0.017039886,
0.03018264,
0.008244456,
0.043029744,
-0.005855781,
-0.018464357,
-0.009151548,
0.03225215,
0.008990287,
-0.0008482988,
0.01952599,
-0.010172866,
-0.0061547854,
-0.0037157165,
-0.052866653,
-0.012813511,
-0.01491662,
-0.0060237614,
0.0049218126,
-0.0025499358,
-0.0003888736,
0.005523181,
-0.003981125,
-0.02269745,
0.02269745,
-0.014849428,
-0.005899456,
0.027011177,
-0.009877222,
0.004313725,
0.0051334673,
0.016797995,
0.0060371994,
-0.013364485,
-0.013639973,
-0.020520432,
-0.0062051797,
-0.009427035,
-0.012867264,
0.026070489,
-0.0073037683,
-0.014513468,
-0.012040803,
0.001709196,
-0.021487996,
-0.02832814,
-0.028973183,
0.012860545,
-0.00946735,
-0.0063395635,
-0.009359843,
-0.16964632,
0.011281534,
0.012437236,
-0.0088559035,
0.020453239,
-0.009131391,
0.0009658847,
0.004223016,
-0.026366133,
0.001886415,
0.02789811,
0.005204019,
-0.02824751,
-0.04472298,
-0.00056945207,
-0.0077203587,
-0.013700445,
0.039777655,
0.0131561905,
0.009917537,
0.02781748,
-0.02279152,
0.02178364,
-0.02254963,
0.0012380122,
0.021420805,
0.018585302,
-0.008405717,
0.0044481093,
-0.014634414,
0.0066251294,
-0.002707837,
0.029403212,
0.004290208,
0.0044010747,
0.00048378226,
-0.0035813327,
-0.0038433813,
-0.018625617,
0.03026327,
0.0071357884,
0.03996579,
-0.028301263,
0.007155946,
-0.008728239,
0.02245556,
-0.005335043,
-0.011960173,
0.037681263,
-0.009742837,
0.014809113,
-0.022899028,
0.017456478,
0.039670147,
0.02178364,
0.008419155,
0.01147639,
0.020856392,
0.0077472357,
-0.0056038112,
-0.015454155,
-0.0010599535,
0.021044528,
-0.015292895,
0.012128153,
-0.042304073,
0.003418392,
0.016032007,
-0.01877344,
-0.00032147163,
-0.010240058,
-0.011032923,
0.0014505069,
-0.007075316,
0.0070350007,
0.019310975,
-0.01970069,
-0.000494281,
0.0067729517,
-0.0017906664,
-0.029134443,
-0.0038601793,
-0.02498198,
-0.02213304,
-0.014701606,
-0.001700797,
0.018961577,
0.035208598,
-0.013256978,
-0.0069678086,
0.023019973,
-0.020722007,
0.002388675,
-0.00013270417,
0.015198826,
0.03459043,
-0.012114714,
0.0046564043,
-0.015601979,
0.022079285,
0.041551523,
-0.0110598,
0.0016050484,
0.0035074214,
0.021528311,
0.0054761465,
-0.023396248,
-0.0072432957,
0.052866653,
-0.036606193,
-0.011946734,
-0.008251175,
0.004700079,
0.028596908,
0.012511147,
0.015601979,
0.016058885,
-0.0026171277,
0.017913383,
-0.026177997,
0.0771364,
0.015628856,
0.00015506649,
0.032574672,
-0.007196261,
-0.011765316,
-0.14749984,
-0.02413536,
-0.0012354925,
0.013485431,
-0.0066486467,
0.012040803,
0.0021501435,
0.026540833,
0.004290208,
0.041175246,
-0.0027515118,
-0.012464113,
0.005805387,
-0.008768554,
0.023759086,
0.022253985,
0.013673568,
0.005217457,
-0.013774356,
0.043970432,
0.01685175,
0.0029262109,
0.004431311,
-0.008493067,
0.008795431,
-0.011859384,
-0.029080689,
0.02295278,
-0.002531458,
0.0012548103,
0.008822307,
-0.015830431,
0.029161321,
0.006947651,
-0.009776433,
-0.029886995,
-0.001977124,
-0.0015722924,
0.021971779,
0.0022358133,
0.00030047414,
-0.011892981,
0.0046295277,
-0.023288742,
0.008614012,
-0.0049957237,
-0.004972207,
0.0033713577,
0.018733125,
-0.00804288,
-0.029456966,
-0.024041291,
-0.03536986,
-0.007048439,
0.040798973,
-0.017456478,
0.00779427,
0.031849,
-0.021084843,
-0.009332966,
-0.019001892,
-0.0038232238,
-0.026016735,
-0.013922179,
0.0026591227,
-0.009978009,
-0.015494471,
-0.015870746,
0.024672896,
-0.013203224,
-0.0127396,
0.00209471,
-0.002949728,
-0.00010645729,
-0.019673813,
-0.0056206095,
0.008647608,
-0.000863417,
-0.0002891355,
-0.01717427,
-0.009413596,
-0.0150644425,
0.025156679,
-0.011832508,
0.020251663,
0.0159245,
0.020681692,
-0.0022274142,
-0.012793354,
-0.0041860603,
-0.020453239,
0.027508397,
0.021084843,
-0.031956505,
-0.026742408,
0.0072768917,
-0.0110598,
-0.000015000085,
0.002722955,
0.011886261,
-0.0015378565,
-0.01693238,
-0.059290204,
0.015239142,
0.004233095,
0.024699772,
0.00034309906,
-0.023853153,
0.002229094,
-0.013008367,
-0.0050998717,
0.0015748121,
-0.03260155,
0.021125158,
0.010838067,
-0.015937937,
-0.010945573,
-0.00754566,
0.051737826,
0.008190703,
0.024914786,
0.022509314,
-0.0095547,
0.0065646567,
0.015454155,
-0.004737035,
-0.028140003,
0.005103231,
-0.020829514,
0.017066764,
-0.01374748,
-0.01491662,
-0.0038501006,
-0.037761893,
-0.019714128,
0.013055402,
-0.012329728,
-0.013949055,
-0.010448353,
0.013169629,
-0.004894936,
0.0022694091,
-0.014311892,
-0.02295278,
0.03426791,
-0.0070618773,
0.01699957,
-0.0062723714,
-0.01651579,
-0.0009986408,
0.00036577636,
-0.023167795,
0.016959256,
0.019082522,
0.010844786,
-0.026513956,
-0.0049822857,
0.027790604,
-0.008721519,
-0.018531548,
0.0048646997,
0.0011750198,
0.0021568625,
0.008284772,
0.021165475,
-0.00058667,
-0.007525502,
0.0064235535,
-0.01843748,
-0.009319528,
0.034482926,
-0.040073298,
-0.033300348,
-0.0005123389,
-0.004380917,
-0.011657809,
0.023248427,
-0.009843625,
-0.003001802,
0.018975016,
-0.01902877,
0.016072322,
0.0125649,
0.0062152585,
-0.023396248,
0.012759757,
0.034644186,
-0.000010951506,
-0.01919003,
-0.0031865798,
0.008237737,
0.019875389,
-0.010952293,
0.015198826,
-0.0040248,
0.014862866,
0.011583897,
0.0014387483,
-0.025868913,
0.014204385,
0.008566977,
0.026245188,
-0.006134628,
0.0044145132,
0.006712479,
-0.0024861034,
-0.009984729,
0.026796162,
-0.011160588,
-0.027118685,
-0.0061447066,
-0.0006072475,
0.0048378226,
0.006987966,
0.00019086723,
0.008157107,
-0.009030602,
0.023248427,
0.0024676255,
0.009225459,
-0.009070918,
0.02521043,
0.007216419,
0.010327408,
-0.01651579,
-0.009507665,
0.020668253,
0.019176591,
0.02967198,
-0.015158511,
-0.0005606331,
-0.02187771,
0.007317207,
-0.008103353,
-0.03897135,
-0.011987049,
0.018343411,
0.013801233,
0.0155079095,
0.020990776,
-0.01751023,
0.089392215,
-0.013109156,
-0.014661291,
0.009144829,
-0.011261377,
0.0041759815,
-0.010381161,
0.024068167,
-0.0015479353,
-0.022186792,
0.007498625,
-0.009507665,
0.015225703,
-0.05028648,
-0.03058579,
0.024955101,
-0.0051065907,
0.00062488543,
-0.007317207,
0.004323804,
-0.0065814545,
-0.0042129373,
0.00084241945,
0.006628489,
-0.053941723,
0.013418239,
0.04190092,
-0.0059028156,
-0.0045287395,
-0.017658053,
0.0018712967,
0.0020678332,
-0.039105732,
-0.011073238,
0.034993585,
-0.020533869,
-0.018343411,
-0.027454644,
0.0025096205,
0.029430088,
-0.005338403,
0.0033125647,
-0.010636491,
-0.005808747,
0.010004886,
0.012618654,
-0.0059364117,
0.0037056378,
-0.0253045
] |
Located in the Kassena-Nankana districts of northern Ghana, the Navrongo health and demographic surveillance system (NHDSS) was established in 1992 by the Navrongo health research centre (NHRC). The NHRC is one of three research centres of the Ghana health service. The activities and potential of the NHDSS for collaborative research are described. The NHDSS monitors health and demographic dynamics of the two Kassena-Nankana districts of northern Ghana and facilitates evaluation of the morbidity and mortality impact of health and social interventions. The total population currently under surveillance is 152 000 residing in | [
-0.005545393,
0.020288855,
0.016067684,
-0.046841383,
0.014610698,
0.024033442,
-0.011104403,
0.0063215443,
-0.009075518,
-0.0080746915,
0.008735101,
-0.005456885,
0.007543641,
-0.023597708,
-0.016871067,
0.010763986,
0.014256665,
-0.028703963,
0.00077912945,
-0.028322697,
-0.020806288,
-0.008755526,
0.017197868,
-0.0012510326,
-0.007693425,
0.014188581,
0.016367251,
-0.020438638,
0.0008859353,
-0.0014067733,
-0.010498461,
-0.019376537,
-0.006243248,
-0.023829192,
-0.013793698,
-0.0016978299,
-0.014528998,
-0.00576326,
0.018219119,
0.009082326,
-0.001901229,
-0.014733248,
0.0037718206,
0.007543641,
0.015087282,
0.017442968,
0.01103632,
-0.009919752,
-0.022127107,
0.0342051,
-0.001141248,
0.034395736,
-0.024169609,
0.009783586,
0.005633902,
0.010723136,
0.01046442,
0.0060492107,
-0.009831243,
-0.033143003,
-0.002658657,
-0.017306801,
-0.04131301,
0.006420265,
-0.026988262,
-0.005797302,
-0.018123802,
0.005215189,
0.010546119,
0.018028485,
0.02851333,
0.011574179,
-0.0048134965,
-0.0066755777,
0.014351982,
0.0039896877,
0.0017148508,
0.003140347,
-0.013385197,
-0.0041326624,
0.012500113,
-0.026797628,
-0.0023029211,
0.016163,
0.028213764,
0.015373233,
0.0035675704,
0.024673427,
0.00055828394,
-0.008088308,
0.0018518686,
0.02834993,
0.012976697,
-0.004939451,
-0.009858477,
-0.010661861,
-0.004398188,
0.027110811,
0.004919026,
-0.0006093465,
-0.030610299,
0.01316733,
-0.0038705415,
-0.0062058023,
-0.0067368527,
0.0062466525,
-0.020465871,
0.014651549,
0.013902632,
0.0012289054,
0.007495983,
0.0307737,
-0.008558084,
-0.015441316,
0.022957724,
-0.03668334,
0.01595875,
-0.013323923,
0.0045854175,
-0.025367877,
0.014964732,
0.0060662315,
0.008067884,
-0.001678256,
0.0064066486,
0.028649496,
-0.0067504696,
0.007039824,
0.0043369127,
-0.0029275864,
-0.021813923,
-0.004074792,
0.02506831,
0.0051471055,
-0.026838478,
0.0045139296,
-0.016435334,
-0.0021956898,
-0.024809593,
-0.021092238,
0.015863433,
0.031563465,
-0.017810619,
-0.017048085,
0.013677956,
0.035920803,
0.0019182499,
0.016353633,
0.013793698,
0.0050109387,
0.022590073,
-0.02875843,
0.0309371,
-0.015414082,
-0.0081632,
0.008381067,
0.02588531,
0.019213136,
-0.012738405,
0.00036956524,
-0.029466497,
-0.007291733,
-0.006978549,
-0.012037146,
0.004119046,
0.02732868,
-0.01838252,
-0.022535607,
0.00030126906,
-0.008013417,
0.008251709,
0.040877275,
-0.0167349,
-0.004415209,
-0.0008178519,
-0.0028033343,
0.01111802,
0.02572191,
-0.030011164,
0.0032118347,
-0.010117194,
0.017633602,
0.019471854,
0.019921204,
-0.021718606,
-0.010968236,
0.019267604,
0.0103691025,
0.01879102,
-0.00173868,
0.014556232,
0.0048305173,
-0.0023386648,
-0.018069336,
-0.6400929,
-0.004003304,
0.034014467,
-0.015332383,
0.0030960927,
-0.01595875,
0.034831468,
0.0095657185,
-0.0155911,
0.032788966,
0.007734275,
0.006004956,
0.014215815,
-0.009286576,
-0.03287067,
-0.023638558,
-0.0011727366,
0.0068559987,
0.050272785,
-0.02252199,
-0.016911918,
0.013283072,
-0.0013454983,
0.017470201,
0.0007178544,
0.002777803,
0.00053488027,
0.0038909665,
-0.020847138,
0.01895442,
-0.018614003,
0.014215815,
0.011860129,
0.030800933,
0.037037373,
-0.02843163,
-0.023202823,
0.03831734,
0.004905409,
0.023761109,
-0.038753074,
-0.0070738657,
0.024646193,
0.0043301047,
-0.0025139798,
0.016503418,
-0.0072508827,
-0.027355911,
0.019798653,
-0.015890667,
-0.012724788,
-0.022998573,
0.0048066885,
0.029520964,
0.0065121776,
-0.02215434,
0.0167349,
-0.014174965,
0.018232735,
0.01653065,
-0.0057258145,
0.012152888,
-0.02802313,
-0.011186103,
-0.016612351,
0.026647845,
-0.008912117,
0.005262847,
-0.014910266,
-0.0034109785,
0.019594403,
0.02867673,
0.0048713675,
0.010260169,
0.03728247,
0.008006608,
0.013834548,
0.0034467224,
-0.010852494,
0.012193738,
-0.011104403,
0.011029512,
-0.013582639,
0.010144427,
-0.0057428353,
-0.034477435,
-0.000055370958,
0.018491453,
-0.0046092463,
-0.0068525947,
0.016789367,
0.01563195,
0.014433682,
-0.01817827,
-0.0039522415,
0.049374085,
0.0077478914,
0.021051388,
0.012220971,
-0.0058653853,
-0.006198994,
-0.009061901,
-0.000026289237,
-0.02502746,
0.0006455158,
0.012282246,
-0.04226618,
0.011996296,
0.05476629,
-0.02248114,
-0.028703963,
0.010886536,
-0.016353633,
-0.0062909066,
0.0156728,
-0.030637532,
0.020683737,
0.009872094,
-0.012248204,
-0.0058347476,
0.014787716,
-0.0029956698,
0.031236665,
-0.044662714,
0.021473506,
0.010988661,
0.014460915,
-0.02826823,
-0.018682087,
-0.0141477315,
-0.021065006,
0.005919852,
0.01895442,
-0.00037594806,
0.04400911,
0.00005366887,
0.022426674,
0.0029463093,
-0.010566545,
-0.04057771,
0.008980201,
-0.006518986,
0.01817827,
-0.017892318,
-0.007060249,
-0.030664766,
-0.01948547,
-0.0047079674,
-0.01132227,
-0.0035267205,
0.009123176,
-0.017919552,
-0.011785237,
0.011186103,
-0.008272134,
-0.008721484,
0.012227779,
-0.013725614,
-0.0032867263,
-0.009824435,
0.020806288,
-0.00049232814,
-0.036138672,
-0.011533328,
0.0027743988,
-0.026865711,
-0.00085614884,
0.02437386,
-0.012418413,
-0.025667444,
-0.007318966,
-0.008149584,
-0.010689095,
0.02215434,
0.031154966,
0.02195009,
-0.009463593,
-0.0061717606,
0.017974019,
-0.014910266,
-0.012554579,
-0.00095146557,
-0.017606368,
-0.021487122,
0.016762134,
0.008796376,
0.024714276,
-0.0006046657,
0.009300193,
0.007502791,
-0.0053547597,
-0.01066867,
-0.03336087,
0.0159996,
-0.006280694,
-0.021977322,
-0.010947811,
0.012037146,
0.01087292,
0.024060676,
0.035730172,
0.020411404,
0.008612551,
-0.021105856,
0.015713649,
-0.004861155,
0.0072236494,
0.005657731,
-0.0046330756,
0.00039658582,
0.01936292,
-0.02633466,
0.0060117645,
0.001359115,
-0.0053139096,
0.006641536,
-0.014624315,
-0.010076344,
-0.0038126707,
0.0033888514,
0.0076525747,
-0.0052696555,
0.024292158,
0.006239844,
-0.027914196,
-0.010804837,
0.010001452,
0.040005807,
0.02900353,
-0.007101099,
-0.0059300647,
0.019839505,
-0.025286177,
0.022630924,
0.015087282,
0.010471228,
-0.009341043,
-0.009225301,
-0.005616881,
0.0050926385,
0.015822584,
-0.010784411,
0.016544268,
-0.005082426,
-0.0001410603,
-0.034531903,
0.01620385,
-0.0031641761,
-0.024864059,
0.014910266,
-0.011826088,
0.016435334,
-0.014692399,
0.00576326,
0.0049326424,
-0.009150409,
0.00047062655,
0.0056849644,
0.029711599,
0.033088535,
0.014542615,
0.00404075,
-0.0047964756,
-0.0023931316,
-0.011792046,
-0.026470827,
0.0155911,
-0.005957298,
-0.0017888915,
-0.020915221,
0.011723963,
0.0063045234,
-0.0023693026,
-0.021909239,
0.0023710045,
0.0070125908,
0.01895442,
-0.023706641,
0.013405622,
0.0054943305,
-0.005262847,
0.015536633,
0.007986183,
0.0029956698,
0.0069683366,
-0.029684365,
-0.020642888,
0.022957724,
-0.022290507,
0.02453726,
0.0047488175,
0.0051368927,
0.011533328,
-0.020193538,
-0.021895623,
-0.022549223,
0.00555901,
-0.010546119,
0.0041088336,
-0.017429352,
0.0164081,
0.0007387049,
-0.0059470856,
-0.03605697,
0.011846513,
-0.012016721,
0.000008530372,
0.0062296316,
-0.014678782,
-0.012220971,
0.007155566,
0.011104403,
0.000820405,
0.00964061,
-0.016775751,
0.010920578,
-0.025041075,
0.010614202,
0.018314436,
-0.0023080274,
-0.020384172,
-0.027641863,
-0.009484018,
-0.0067674904,
0.083061755,
-0.005824535,
0.0033445973,
0.007598108,
0.0012876274,
-0.0011531627,
0.0002810568,
-0.042810846,
0.01960802,
0.02075182,
-0.0036458664,
-0.030800933,
0.024836825,
0.0068832324,
0.012227779,
0.004193938,
-0.0040373458,
-0.009293385,
-0.0164081,
0.023720259,
-0.0009974219,
-0.024360241,
0.042484045,
0.04607885,
0.00081104354,
-0.008265325,
-0.0034075745,
0.01140397,
0.0013871994,
0.0008370004,
-0.0027250382,
0.023638558,
-0.00029807765,
0.014801332,
-0.03758204,
0.0065462193,
0.008932543,
-0.01251373,
0.011220145,
-0.0081904335,
0.012241396,
-0.00484073,
0.0047488175,
0.0035913996,
0.041530877,
-0.0032135367,
0.008524043,
0.021078622,
-0.011356312,
0.011267804,
0.01628555,
-0.03532167,
-0.014842182,
-0.009919752,
-0.0068832324,
-0.026688695,
0.027001878,
0.0008859353,
-0.013848164,
-0.032925133,
-0.035948038,
-0.013398814,
0.020111838,
0.0027522717,
-0.020179922,
-0.012282246,
-0.009116367,
-0.0031931116,
-0.013814122,
-0.010682286,
0.015237066,
-0.025245326,
-0.017538285,
0.015141749,
0.02117394,
-0.0052083805,
0.017252335,
0.0082449,
-0.0031846012,
0.014883032,
0.010811645,
-0.0051709344,
-0.0023676003,
-0.00039041578,
-0.026429977,
-0.0039352207,
0.014297515,
-0.013473705,
-0.00078125705,
0.0054636933,
0.006760682,
-0.007053441,
0.015618333,
0.0017020851,
-0.038616907,
0.016435334,
0.043709546,
0.02547681,
-0.021051388,
-0.016312784,
-0.004033942,
-0.013773273,
-0.009987836,
0.0047692424,
0.04065941,
0.0054943305,
-0.016557883,
0.021446273,
-0.033605967,
-0.030909866,
0.03605697,
-0.037963305,
-0.006181973,
-0.005661135,
0.007175991,
0.012282246,
0.023230057,
0.017851468,
-0.018736552,
0.0023607921,
-0.0001151035,
0.0060117645,
0.020397788,
0.004534355,
-0.02284879,
0.024006208,
0.004857751,
-0.0000072205644,
-0.034395736,
-0.006461115,
-0.001879102,
0.041040678,
-0.029711599,
-0.038181175,
-0.010348678,
-0.0042654253,
-0.024850443,
-0.006696003,
-0.00020935647,
-0.02933033,
-0.019757804,
-0.014311132,
0.002639934,
-0.021854773,
0.02030247,
-0.023202823,
0.0086534005,
-0.021841155,
0.0006935997,
0.008374259,
-0.0069308905,
0.000839128,
-0.00076721486,
-0.004047558,
-0.007291733,
0.0037139498,
-0.008312983,
0.01099547,
0.038616907,
0.020084605,
0.02268539,
0.00019042077,
0.0035982078,
0.004258617,
0.005998148,
-0.02892183,
-0.0064849444,
0.006341969,
-0.007502791,
0.026457211,
0.029684365,
-0.011145254,
-0.02350239,
0.002437386,
-0.0036628873,
-0.009286576,
0.01226863,
-0.026470827,
-0.00787725,
-0.043137643,
0.0003459488,
-0.026021477,
-0.0068457862,
0.0061138896,
-0.05394929,
-0.020152688,
0.041421942,
-0.0053888015,
0.016557883,
-0.0052492307,
0.017306801,
0.014447299,
-0.010920578,
0.025000226,
0.0077547,
-0.028050363,
0.0013259243,
-0.00568156,
0.0031965158,
0.032298766,
-0.0048849843,
0.0066891946,
0.030120099,
-0.0059913397,
0.0041462793,
0.04098621,
-0.016149383,
-0.017538285,
-0.009953794,
-0.024441943,
-0.008231283,
-0.005562414,
-0.011226953,
-0.031209433,
0.00020010138,
0.017619984,
-0.0010152938,
0.02674316,
-0.02457811,
0.008088308,
-0.0031641761,
0.0014527297,
0.012663513,
-0.0079998,
0.015863433,
0.022304123,
-0.011601412,
-0.024959376,
0.023039425,
0.011819279,
-0.031536233,
0.033197466,
0.014515382,
-0.035920803,
-0.0071079074,
0.01883187,
0.019771421,
0.008135967,
-0.052206356,
0.018981652,
0.015863433,
-0.013514556,
-0.009824435,
0.009545294,
-0.01879102,
0.033170234,
-0.00056764536,
-0.018409753,
-0.002216115,
0.008707867,
-0.017974019,
0.0043232962,
-0.038616907,
0.0160813,
-0.00053573126,
-0.023761109,
0.0075844913,
-0.012554579,
-0.016966384,
0.0043301047,
0.01140397,
0.009415935,
-0.0014484745,
-0.002199094,
0.035621237,
0.017865086,
0.010818453,
0.019349303,
-0.013548598,
0.026770394,
-0.0016884684,
-0.02826823,
0.026402744,
0.0175519,
0.020656506,
0.0044901003,
-0.004299467,
-0.01932207,
-0.004997322,
-0.02900353,
0.008013417,
0.0028458864,
-0.014991966,
-0.023393458,
-0.020207154,
-0.021051388,
-0.02092884,
-0.017415734,
0.022916874,
-0.023570474,
-0.03523997,
-0.002978649,
-0.0060117645,
0.03499487,
-0.014202198,
0.013582639,
0.0017548498,
0.01275883,
-0.0164898,
0.024523642,
0.031209433,
0.027206128,
-0.0006059423,
0.0016552778,
-0.0042143627,
-0.031209433,
0.00972231,
-0.023693025,
-0.022508373,
-0.015985982,
-0.000110741916,
0.025422344,
0.01936292,
0.013643914,
0.018273586,
-0.014447299,
0.0076866164,
-0.019539937,
-0.0337149,
0.045643114,
-0.007659383,
-0.011540137,
0.011022703,
-0.029711599,
0.026606994,
-0.025081927,
-0.0010731646,
0.028077597,
-0.027846113,
-0.014338365,
0.004507121,
0.015100899,
-0.025367877,
0.005855173,
-0.03581187,
0.012357138,
-0.017088935,
0.011247379,
-0.0061547398,
-0.030637532,
0.0032560888,
-0.012867764,
-0.005719006,
-0.01644895,
0.0043913797,
0.0010808241,
0.011608221,
-0.015740883,
-0.021568822,
0.010975045,
-0.006134315,
0.036411006,
0.024646193,
-0.00984486,
0.0032509826,
-0.01924037,
-0.036656104,
-0.0051300847,
0.0024152587,
0.035730172,
0.008217667,
0.027614629,
0.008394684,
0.012241396,
-0.01579535,
0.011887362,
-0.02117394,
-0.010879728,
0.0152915325,
-0.021963706,
0.019812271,
-0.00463648,
-0.043219347,
0.019471854,
0.036928438,
0.0031369429,
-0.0024850443,
0.013711997,
-0.007039824,
-0.018722937,
0.0008659358,
-0.012166505,
-0.019539937,
-0.015032816,
0.008299367,
-0.025817227,
-0.0017020851,
-0.0020101625,
0.008435533,
0.0002291432,
-0.016367251,
-0.0031556657,
0.0037956499,
0.0056066685,
-0.022821557,
0.0059675104,
0.028785663,
-0.019049736,
-0.0043709544,
0.013997948,
-0.005337739,
0.039433908,
0.014978349,
0.0039045832,
-0.013432856,
-0.006297715,
-0.042184476,
-0.0063317567,
-0.0035982078,
-0.029983932,
-0.0075912997,
-0.01251373,
0.008871268,
-0.02092884,
0.0042484044,
-0.022453906,
-0.03886201,
-0.039624542,
0.021568822,
-0.021350956,
-0.024441943,
-0.0037718206,
0.011226953,
-0.00996741,
-0.007495983,
-0.0013523066,
0.019008886,
-0.012404797,
0.00012340117,
0.017797003,
0.01538685,
-0.016231084,
0.019253986,
-0.02851333,
-0.02199094,
0.024441943,
0.17854191,
0.004742009,
-0.0014723036,
0.0062670773,
-0.022167956,
0.0037173538,
0.008415109,
0.012561388,
0.017960401,
0.023025807,
-0.0020493104,
-0.004193938,
-0.02649806,
0.010600586,
-0.003378639,
-0.04065941,
-0.016680434,
-0.0010918876,
0.0024510026,
0.011009087,
-0.0053888015,
-0.007707041,
-0.003157368,
-0.013323923,
0.014011565,
-0.0032339618,
-0.014311132,
0.0099061355,
0.01989397,
0.017769769,
-0.012690746,
-0.01842337,
0.0075504496,
-0.0028731197,
-0.005021151,
-0.0052832724,
0.006478136,
0.01267713,
-0.0031965158,
0.021636905,
-0.014692399,
-0.011792046,
-0.011914596,
0.008605742,
0.007952142,
-0.00001075771,
0.013650723,
0.0166532,
-0.026184877,
0.008503617,
-0.049864285,
-0.013010738,
-0.020588422,
0.02329814,
-0.025313409,
0.010675478,
0.0029360969,
-0.005426247,
-0.0072849244,
0.012350329,
-0.009742735,
0.028104829,
-0.008687442,
0.023842808,
-0.011138445,
0.031427298,
0.0041496833,
-0.010164852,
0.0052832724,
-0.007339391,
0.03635654,
-0.020275237,
-0.002621211,
-0.0058279396,
-0.021718606,
-0.023733875,
0.01960802,
0.009129984,
0.026239345,
0.019880354,
-0.0018705915,
-0.0007433857,
-0.020629272,
0.0015071963,
-0.019431004,
-0.02629381,
0.012786063,
-0.002823759,
-0.025612976,
-0.0065121776,
-0.00812235,
0.019008886,
-0.036247604,
-0.015904283,
-0.0128813805,
0.018532302,
0.023978975,
0.0124320295,
0.006015169,
-0.011717154,
-0.004374359,
0.07440154,
0.002558234,
-0.0054773097,
-0.010028685,
0.0012501815,
-0.013623489,
0.019213136,
-0.0152915325,
-0.011009087,
0.010600586,
-0.032761734,
-0.004701159,
-0.015114516,
0.024305776,
0.040141974,
0.010450803,
-0.02519086,
-0.009647419,
-0.01919952,
0.013385197,
-0.025898928,
-0.009872094,
0.035267204,
-0.024441943,
0.00095827394,
0.0026926987,
-0.016966384,
-0.0012535857,
-0.017946785,
-0.006134315,
-0.012493305,
0.008381067,
-0.009817627,
0.0016680434,
0.00035488475,
0.007305349,
0.010573353,
-0.03556677,
0.0019914396,
0.0055487975,
-0.0166532,
0.017892318,
-0.010852494,
0.023257291,
-0.0338783,
0.0067470656,
0.011179295,
0.0021769668,
0.0014467724,
-0.010505269,
0.00324077,
0.017034467,
-0.0035165078,
0.022113489,
-0.0057564517,
-0.011124828,
-0.02506831,
0.018886337,
0.011873745,
-0.016217466,
0.015305149,
0.04008751,
-0.013698381,
-0.008292559,
0.03589357,
-0.17385778,
0.027546545,
0.018736552,
-0.029466497,
0.009061901,
-0.0034450202,
0.0055692224,
0.023938125,
-0.0030365197,
-0.022426674,
0.017238718,
-0.00012020976,
-0.031536233,
-0.025504043,
0.002297815,
-0.0047522215,
-0.016612351,
0.008156392,
0.027233362,
0.007720658,
0.024074292,
-0.011179295,
-0.005443268,
-0.010920578,
0.011594604,
-0.00551816,
-0.027451228,
0.022208806,
-0.019880354,
-0.00931381,
-0.011295036,
-0.009810818,
0.016871067,
0.0030960927,
-0.010314636,
0.0123162875,
-0.0012510326,
-0.010920578,
-0.008918926,
0.0028067383,
0.031971965,
0.017020851,
0.026933795,
-0.015141749,
0.023652175,
0.032680035,
0.015209832,
-0.023556858,
0.017701685,
-0.022099873,
0.0066483445,
-0.013323923,
0.026035095,
0.010430378,
0.019825887,
0.00039594754,
-0.0042347875,
0.015032816,
0.0049905134,
-0.004524142,
-0.025245326,
-0.008496809,
0.0049292385,
-0.009095943,
0.008292559,
-0.02412876,
-0.03684674,
-0.0058313436,
-0.015985982,
0.014460915,
-0.030256266,
0.012071188,
-0.012166505,
-0.017987635,
0.031073267,
0.01107717,
-0.025544893,
-0.006696003,
0.010512077,
0.0031607721,
0.026157644,
0.008088308,
-0.013507747,
-0.0072508827,
0.008809992,
-0.022140723,
0.0056679435,
0.015128133,
0.010103577,
0.011601412,
0.012969889,
-0.0351038,
0.04373678,
-0.010117194,
0.010661861,
0.0064679235,
-0.003458637,
-0.00065147306,
0.0068423823,
0.0055658184,
0.0031114116,
-0.004966684,
-0.020070987,
0.008578509,
0.0079998,
-0.00025850418,
-0.012207354,
0.016571501,
0.034123402,
-0.0013991139,
-0.01960802,
0.004779455,
0.017497435,
0.0103622945,
0.011948638,
0.043518912,
0.014256665,
-0.022862406,
0.0038671375,
-0.022835175,
0.042892545,
-0.0021718605,
-0.041122377,
-0.0008182774,
0.010920578,
-0.022304123,
-0.108443245,
0.013255839,
0.018205503,
-0.005576031,
0.0057121976,
0.03327917,
-0.0065428154,
-0.006124102,
-0.01390944,
0.0025156818,
-0.04365508,
-0.01620385,
0.0110567445,
0.003839904,
0.050926387,
0.014774099,
0.009075518,
-0.021228405,
0.02781888,
0.020874372,
-0.013412431,
-0.008639784,
-0.0061853775,
-0.013725614,
-0.0013940077,
0.004357338,
-0.018654853,
0.0075504496,
0.009164026,
0.025081927,
0.009695076,
-0.022004556,
0.0324894,
-0.019757804,
-0.041421942,
-0.027601013,
-0.020166304,
-0.0075368327,
0.010859303,
-0.013882206,
0.0013216691,
0.009381893,
0.014460915,
-0.009838052,
0.00096678437,
-0.0024680234,
-0.010634628,
0.008850843,
0.010028685,
-0.0026450402,
-0.011826088,
-0.018300818,
-0.004224575,
-0.014093265,
0.014106882,
-0.01218693,
0.013650723,
0.0054943305,
-0.0150600495,
-0.004561588,
-0.02649806,
0.0086534005,
-0.02350239,
0.010321444,
0.012826913,
0.010083152,
-0.041830443,
0.010900153,
0.019499088,
-0.0049088136,
0.004445846,
0.014883032,
-0.031073267,
-0.013330731,
-0.01985312,
0.0037377789,
-0.030310731,
-0.014093265,
-0.0018927186,
-0.01985312,
-0.010226128,
-0.010124003,
-0.0056100725,
-0.005960702,
-0.0015565568,
0.010641436,
-0.0034484244,
0.0164898,
0.01883187,
-0.025449576,
0.02293049,
0.023978975,
-0.0155911,
-0.004844134,
0.031509,
0.03532167,
0.009463593,
-0.0046875426,
-0.018899953,
-0.0168983,
-0.024264926,
-0.009586143,
-0.07717935,
-0.0009369979,
0.0168983,
-0.0111724865,
-0.019621637,
-0.0139162475,
-0.0029173738,
-0.0019216541,
0.00034999126,
0.0045445673,
-0.031944733,
0.010484844,
-0.015713649,
0.01296308,
-0.049837053,
-0.0076457663,
0.02608956,
0.015482166,
0.040414307,
0.013460089,
-0.01079122,
0.010416761,
0.008816801,
0.012112037,
0.0034926787,
-0.0019080375,
0.01595875,
0.0070125908,
0.0018059124,
-0.007598108,
0.021813923,
-0.0150600495,
-0.007965758,
-0.0026127007,
-0.0025292984,
-0.028540563,
-0.007618533,
0.008939351,
0.017374884,
0.046460114,
-0.02580361,
-0.039107107,
-0.027669096,
-0.009238918,
-0.007114716,
0.0038262873,
-0.0021480315,
0.012860955,
0.000037020352,
-0.012261821,
0.014869415,
0.011376737,
-0.00463648,
-0.013174139,
-0.017987635,
-0.0042347875,
0.007911292,
0.013861781,
0.011894171,
-0.043382745,
0.029057996,
0.023475157,
0.034150634,
0.01817827,
0.02777803,
-0.025544893,
0.0016118746,
-0.0011855023,
0.01156737,
-0.013153714,
-0.029384797,
-0.009232109,
0.020602038,
0.017197868,
-0.0037752248,
-0.0064509027,
-0.01834167,
-0.0029837552,
-0.013494131,
0.0056407102,
-0.0149511155,
0.010947811,
-0.020847138,
0.049428552,
0.019294837,
0.0008182774,
-0.038943708,
0.02900353,
0.009729118,
0.009661035,
-0.032543868,
0.017334035,
-0.0049326424,
-0.013705189,
-0.015849816,
0.007924908,
0.017048085,
-0.0069104657,
0.030664766,
0.048502617,
-0.002459513,
0.023516009,
-0.019866737,
-0.030120099,
-0.015945133,
0.015100899,
0.009361468,
-0.013929864,
0.012534155,
-0.0047215843,
0.011737579,
0.016367251,
-0.008231283,
0.015713649,
-0.023910891,
-0.0024697254,
-0.0097972015,
0.006896849,
-0.01875017,
0.0067096194,
0.009606568,
0.019785037,
0.015659183,
0.010736753,
0.006638132,
0.014651549,
0.022494758,
-0.010103577,
-0.003157368,
0.007203224,
-0.0099129435,
0.002621211,
-0.022467524,
-0.01144482,
-0.024414709,
-0.023352608,
0.011710346,
0.00035318267,
-0.015904283,
0.072277345,
0.0056509227,
-0.019185903,
0.0077683167,
-0.020697355,
-0.004919026,
0.0038705415,
0.0066279196,
-0.021704989,
-0.013146905,
0.025109159,
-0.020561188,
0.013943481,
-0.023516009,
-0.012009912,
0.019621637,
-0.014093265,
0.037881605,
-0.006501965,
0.009381893,
0.009095943,
-0.027492078,
0.01140397,
-0.0014910266,
-0.008932543,
0.009892519,
0.031536233,
0.0064509027,
-0.015781732,
0.0012016721,
-0.012969889,
0.01271798,
-0.029439265,
0.0058177267,
-0.026797628,
0.006253461,
0.0019148458,
0.0027029112,
0.02329814,
0.024441943,
0.010151235,
0.014433682,
-0.0059675104,
0.0028509926,
0.014733248,
-0.025858076,
-0.013698381,
-0.018123802,
0.007441516
] |
Information on the prevalence of COPD was obtained from vital statistics, health interview surveys, hospital charge records, national publications, and the World Health Organization (WHO). These data indicate that COPD is a common disease with implications for global health. In the United States, morbidity caused by COPD is 4%, making COPD the fourth leading cause of death, exceeded only by heart attacks, cancer, and stroke. Internationally, there is substantial variation in death rates possibly reflecting smoking behavior, type and processing of tobacco, pollution, climate, respiratory management, and genetic factors. The Global Obstructive Lung Disease Initiative, initiated by the | [
0.002117638,
0.0031624432,
0.0040141693,
-0.049477987,
-0.0027560433,
0.010793725,
-0.036896728,
0.030095372,
-0.025760442,
0.016330725,
-0.021948693,
0.02188641,
-0.0027062166,
0.024726536,
0.0025582935,
0.020478804,
0.0364732,
-0.017302347,
0.020877419,
-0.012494064,
-0.023904394,
0.023655262,
-0.022696096,
0.010027639,
-0.0067079295,
0.019581921,
0.028276695,
-0.018174317,
-0.005677138,
-0.030543812,
-0.0018093347,
-0.010594418,
-0.03360816,
-0.018298883,
-0.0114913,
0.013403403,
-0.012905135,
-0.009516913,
0.003662268,
-0.040434428,
0.0108684655,
0.005907587,
0.009006189,
0.0034037915,
-0.02125112,
0.027504379,
-0.0002411538,
-0.025473937,
-0.005409319,
0.00093269494,
0.008501694,
0.050997704,
-0.010918292,
-0.02640819,
0.027753513,
-0.016841449,
-0.023455953,
0.014001324,
0.020566002,
-0.019943167,
-0.011690607,
-0.020030363,
-0.035127874,
0.002460197,
-0.023804741,
0.011927284,
-0.028201954,
0.024352835,
0.013116898,
0.033807468,
0.042851027,
0.03074312,
0.011927284,
0.035028223,
0.008277473,
0.005963642,
-0.01401378,
0.0037650357,
-0.024078788,
0.012263615,
0.01732726,
-0.02581027,
-0.0014862393,
0.03874032,
0.020478804,
-0.0061567207,
0.0100525515,
0.014898205,
-0.018734867,
0.0064027403,
-0.00087508274,
0.0076795514,
-0.00010296236,
0.012226244,
-0.007150142,
-0.0025925494,
0.0044065556,
0.04026003,
0.005101016,
-0.053015687,
-0.0116220955,
-0.012338355,
-0.025150064,
-0.0052909805,
-0.020590914,
0.00032173304,
-0.0015025886,
0.0005815719,
0.010027639,
-0.011609638,
-0.008034567,
0.039014366,
-0.0059231576,
-0.011310678,
0.025685702,
-0.014773639,
-0.011086457,
0.0054684887,
-0.010650473,
-0.020939702,
0.01574526,
0.009548056,
0.031091906,
-0.023754915,
-0.01706567,
-0.016828993,
-0.050873138,
0.0066020475,
0.01819923,
-0.004612091,
-0.007349449,
0.00085406203,
0.01831134,
-0.0022172914,
-0.011161197,
0.021599907,
0.004347386,
0.011952197,
-0.029397797,
-0.012313441,
-0.0033041378,
0.0139016695,
0.003624898,
-0.019519638,
-0.001849819,
0.052118804,
0.032487057,
-0.0072684805,
0.0066145044,
0.0024804391,
0.016928647,
-0.0054653743,
0.010382654,
-0.0053283507,
0.0148483785,
0.0010339055,
0.014076063,
0.04870567,
0.01035774,
-0.02979641,
-0.0070255753,
-0.012537662,
-0.008015882,
0.014113434,
0.009180583,
0.017426914,
0.012400638,
-0.0273549,
-0.0056273113,
0.018410994,
-0.006100666,
0.029098837,
-0.014723811,
0.026208883,
0.027529292,
0.0020553544,
-0.027604032,
0.025835183,
-0.021986064,
-0.0036498113,
-0.023617892,
0.02957219,
0.008233874,
-0.000039316437,
-0.025075324,
-0.0017750788,
0.024664253,
-0.009647709,
0.009952898,
-0.02075285,
0.0010533691,
0.019631749,
0.012238702,
-0.020864962,
-0.64854527,
-0.015060143,
-0.005032504,
-0.010750126,
0.0012659115,
0.009572969,
0.016604772,
0.0070380317,
-0.009068473,
0.017887812,
0.007330764,
0.010426252,
0.011453929,
-0.0063186577,
-0.0037058664,
-0.0104387095,
-0.028550742,
0.003160886,
-0.030518899,
-0.007841488,
0.00025283196,
0.017825529,
-0.011727977,
0.008943906,
-0.01529682,
0.03455487,
0.009211725,
-0.024689166,
0.020167386,
0.031066993,
0.019768773,
0.018386079,
0.0071937405,
0.021238662,
0.03861575,
-0.022247655,
-0.011921056,
0.014960489,
0.020229671,
0.008134221,
-0.011316906,
0.009473315,
0.023854569,
-0.011684379,
-0.0006349021,
0.017476741,
0.013527969,
0.0070691737,
0.016492663,
-0.009161898,
0.0056802523,
-0.0014675542,
-0.0017377087,
-0.0018747323,
0.008875394,
0.014275371,
0.009759819,
-0.021413056,
0.011354276,
-0.015047686,
-0.00855152,
0.01812449,
-0.00937989,
-0.00787263,
-0.013390945,
0.018959088,
-0.01920822,
0.022123087,
-0.0063715987,
-0.010326599,
-0.007237339,
0.03178948,
-0.0075362995,
-0.0044470397,
0.033433765,
0.0089127645,
0.019058742,
0.006913465,
-0.014449764,
-0.000096490716,
0.0040920237,
0.0053906343,
-0.028750049,
-0.0011779361,
0.013802016,
0.005266067,
-0.017962553,
-0.004459496,
0.00058468606,
0.014462221,
0.016305812,
-0.007143914,
-0.002673518,
0.005786134,
-0.0016427265,
0.021562537,
-0.0178629,
-0.020229671,
0.00086651876,
0.007592355,
-0.03236249,
0.0046027484,
-0.0023294017,
0.02603449,
0.040359687,
0.022696096,
-0.024327923,
0.0013749076,
0.019295419,
-0.0042259335,
-0.00021857604,
-0.0075425277,
0.016530033,
-0.0052286973,
0.023779828,
-0.0073369923,
0.032113355,
-0.0082463315,
0.0071190004,
-0.032113355,
0.006720386,
-0.0015173809,
0.004640118,
-0.029148662,
-0.008975048,
0.004854996,
0.011534899,
-0.01940753,
0.00094203744,
-0.021450426,
0.011821402,
-0.018448364,
0.010993032,
-0.005639768,
0.023817198,
-0.011179882,
0.008732142,
-0.0066331895,
-0.0074304175,
-0.013540426,
-0.013590253,
0.0012923819,
0.019893339,
-0.0029646931,
0.00689478,
-0.013552883,
0.005549457,
-0.019083655,
-0.008321071,
-0.0122885285,
0.0050729886,
-0.02155008,
0.0042664176,
0.02957219,
0.014773639,
0.006128693,
0.015309276,
-0.0059698704,
-0.012705827,
-0.002067811,
0.014561875,
-0.0071999687,
-0.003053447,
-0.011167426,
0.0054373466,
-0.0139016695,
-0.018548017,
0.019594379,
-0.0073058507,
-0.022870488,
0.003285453,
-0.018846978,
0.010650473,
0.008713457,
0.02121375,
-0.0032574253,
0.0000132474015,
-0.025934836,
-0.00028494687,
-0.021749387,
0.0030347619,
-0.000780879,
-0.0011654794,
-0.021363229,
-0.00086106895,
-0.002872825,
0.014449764,
-0.0058421893,
0.0031733427,
0.021637276,
-0.0030051772,
0.029173575,
-0.008738371,
0.019133482,
0.020852504,
0.026134143,
0.009510686,
-0.0024835533,
-0.0017657363,
0.025498852,
0.022770835,
0.0038055198,
0.025860095,
-0.011061544,
0.015732804,
-0.009716221,
-0.006162949,
-0.014536961,
0.0122823,
-0.0007462338,
0.0050729886,
0.014437308,
0.014885749,
0.006664331,
-0.006309315,
0.041630268,
-0.001832691,
-0.02350578,
0.0017081241,
-0.016704425,
-0.006589591,
0.003235626,
0.026458018,
-0.016168788,
-0.0127182845,
0.0070193466,
-0.0030721321,
0.011211025,
0.0032169411,
-0.0037152087,
-0.018435907,
-0.012051851,
0.023966677,
0.0019525867,
-0.022733465,
0.013316206,
-0.02369263,
-0.02162482,
0.04207871,
0.010986804,
-0.00708163,
0.008557748,
0.02279575,
-0.0134283155,
-0.02132586,
-0.0114726145,
0.023119623,
0.0053968625,
-0.011024173,
-0.0010307914,
-0.010725213,
-0.005549457,
0.010015181,
0.0020335552,
-0.005421776,
-0.019121025,
0.018822065,
0.008408268,
0.039911248,
0.016206158,
0.020466348,
-0.024053875,
0.02376737,
-0.005315894,
0.009429717,
-0.015570867,
-0.03639846,
0.005527658,
0.007847717,
-0.016679512,
-0.01382693,
0.0045030946,
0.015695434,
-0.04118183,
0.032088444,
0.005063646,
-0.015496126,
-0.017763246,
-0.004185449,
0.020428978,
0.00245864,
-0.011983339,
0.007673323,
0.025449025,
-0.02026704,
-0.0128054805,
0.020105103,
0.010943205,
-0.026657324,
0.034031685,
-0.017626222,
0.02523726,
-0.0034536184,
0.0073681343,
0.010226945,
0.011005489,
0.011883685,
-0.007162599,
0.00708163,
0.014038693,
-0.004054654,
-0.010949434,
-0.00060414965,
0.01378956,
0.019569466,
0.022160457,
-0.014399937,
0.021413056,
-0.015359103,
0.0047677993,
-0.013316206,
-0.026308537,
-0.022135545,
-0.0014449764,
0.0021441083,
0.012002024,
0.014487134,
-0.0029678072,
0.0070318035,
-0.02912375,
0.01842345,
-0.012070536,
-0.007810347,
-0.02825178,
0.06208416,
-0.0005967535,
-0.009554284,
0.011036631,
-0.006720386,
0.00531278,
0.009734906,
-0.011559811,
0.022907859,
0.016716883,
0.015583323,
-0.017813072,
0.029397797,
0.014586788,
0.02519989,
0.009778504,
-0.021911323,
-0.019145938,
-0.010507221,
-0.010202032,
-0.012114135,
-0.0036498113,
0.020491261,
0.039985985,
0.010743898,
-0.008613803,
0.016268441,
0.02610923,
0.0075487564,
0.0111923395,
-0.0154463,
0.023107167,
-0.011958426,
0.03582545,
-0.019432442,
0.027753513,
0.03756939,
-0.016866364,
-0.0025972207,
0.02309471,
0.005661567,
-0.01393904,
-0.0069383783,
0.022995057,
0.020653198,
-0.0020210985,
0.0006991319,
0.033732727,
0.022446962,
-0.011615867,
0.022696096,
-0.009554284,
-0.01883452,
-0.034853827,
0.008009654,
-0.017676048,
0.02184904,
-0.003970571,
0.00018227646,
-0.022272568,
-0.02091479,
-0.026582584,
-0.011547355,
0.0029039667,
-0.014238001,
-0.013216551,
-0.018087119,
-0.007822803,
-0.006739071,
-0.017489199,
0.01842345,
-0.02478882,
-0.004543579,
0.00082525593,
-0.001103196,
-0.004487524,
0.022446962,
-0.018224142,
0.016903734,
-0.009822103,
0.0010697185,
0.005898244,
-0.012736969,
-0.022459418,
-0.0078165755,
0.011167426,
-0.0057145082,
-0.01766359,
-0.024128616,
0.032163184,
0.003341508,
-0.025324458,
-0.00009765853,
-0.006732843,
0.0059231576,
0.014188174,
0.039388064,
0.026981197,
-0.01766359,
-0.02463934,
0.013303748,
0.0029055239,
-0.01728989,
-0.027031025,
0.013017245,
-0.019606836,
0.007654638,
0.003951886,
0.007162599,
-0.020864962,
0.030693293,
-0.031814396,
0.013926583,
0.0023465296,
0.011254623,
0.014350111,
-0.011360505,
0.023829654,
0.015570867,
-0.020740395,
0.003699638,
-0.012892677,
0.02067811,
0.011727977,
-0.022434505,
-0.016567402,
-0.006489937,
-0.013353575,
-0.060639184,
-0.019046284,
0.00090856006,
0.0071252286,
0.01002141,
-0.033134803,
-0.014026237,
0.010725213,
0.0022920317,
-0.0139016695,
-0.03231266,
-0.02272101,
-0.0054373466,
-0.014262914,
-0.020242127,
0.0026174628,
0.050773483,
-0.032088444,
-0.00042313832,
-0.011815174,
0.006408969,
0.0067452993,
-0.0016069135,
-0.001203628,
-0.007405504,
-0.0069383783,
-0.006483709,
-0.029098837,
-0.022745922,
-0.0139888665,
0.015359103,
0.025324458,
0.002729573,
0.0071376855,
0.017040757,
-0.005817276,
0.00420102,
0.007941142,
-0.0060695237,
-0.01058819,
0.00059869984,
-0.0039082877,
0.010856008,
0.0134283155,
-0.0005675581,
-0.0039612288,
0.002804313,
-0.019731402,
-0.004883024,
-0.013067071,
-0.014898205,
-0.018734867,
-0.021525167,
-0.0036030987,
-0.00862626,
0.008333528,
-0.05465997,
-0.012070536,
0.024464946,
-0.018298883,
-0.01058819,
-0.020229671,
-0.012381953,
-0.011584725,
0.029073922,
0.007343221,
0.011316906,
-0.016131418,
-0.012058079,
-0.011453929,
0.005016933,
-0.010936977,
-0.012269843,
0.02000545,
0.001275254,
-0.0032761104,
0.007779205,
0.021139009,
-0.030643467,
0.009560512,
0.01017089,
-0.021674646,
-0.0037681498,
-0.0066207326,
0.011771576,
-0.03809257,
-0.0036747246,
0.015346646,
-0.0010845109,
0.032237925,
-0.019581921,
-0.029223403,
-0.003288567,
-0.018523103,
0.0026797461,
-0.0041729924,
0.029223403,
-0.002676632,
-0.02184904,
-0.027429638,
0.017775701,
0.010413796,
0.0002518588,
0.025424112,
0.010781269,
-0.02757912,
0.008240103,
0.003375764,
0.020291954,
-0.009510686,
-0.022534158,
0.01548367,
0.010195804,
-0.005150843,
0.006626961,
0.010089922,
-0.01842345,
0.008345985,
-0.005798591,
-0.0051882127,
-0.017763246,
-0.052467592,
0.0057207365,
0.007654638,
-0.03029468,
-0.0019821713,
0.004325587,
-0.019843513,
-0.008345985,
-0.016853906,
-0.0039114016,
0.021537622,
-0.010532134,
0.0047335434,
0.0050729886,
-0.0024570827,
0.019033827,
0.015807545,
-0.0134283155,
0.028600568,
-0.036099497,
0.029896064,
0.008501694,
-0.016442835,
-0.009317607,
-0.006088209,
0.015770175,
-0.011572268,
-0.02071548,
-0.017426914,
0.0012075207,
-0.006751528,
0.011696835,
0.0018264627,
-0.0068324963,
0.0037837205,
-0.017152866,
-0.03263654,
-0.019606836,
-0.009535599,
0.011179882,
-0.007592355,
-0.009741134,
-0.020640742,
0.0073369923,
0.013577796,
0.009548056,
-0.0060103545,
-0.004668146,
0.030045545,
-0.0400109,
0.01890926,
0.018435907,
0.0152345365,
-0.0075176144,
0.020503718,
-0.020553544,
-0.0396372,
0.0037712639,
0.008869166,
-0.02196115,
-0.019768773,
-0.008638717,
0.0010993032,
0.0014582117,
0.00499202,
0.019320332,
0.017314805,
-0.0045373505,
-0.03345868,
-0.0076982365,
0.049976256,
-0.032611623,
0.014188174,
0.029323056,
0.0059293862,
0.011254623,
0.01175289,
0.0043598427,
0.017887812,
-0.0186103,
-0.036348633,
-0.03296041,
0.02648293,
-0.020765308,
0.0037681498,
-0.026009576,
0.00582039,
-0.009373662,
0.011628323,
0.008458095,
0.02158745,
0.003718323,
-0.0014955818,
-0.015633151,
-0.011503756,
-0.010687843,
-0.022708552,
-0.0048861383,
-0.0010105493,
-0.03846627,
-0.0035812994,
-0.014026237,
0.020105103,
0.010102378,
-0.00040990306,
-0.047783878,
-0.0017750788,
-0.03243723,
0.007112772,
-0.013914127,
0.025461482,
-0.010320371,
0.009896843,
-0.015346646,
0.012892677,
-0.008539064,
0.003248083,
-0.03771887,
-0.03714586,
0.033433765,
-0.014561875,
-0.006757756,
-0.007741835,
-0.0034941025,
-0.008221418,
0.010444937,
-0.012151505,
-0.008657402,
0.018597843,
0.009261551,
-0.01732726,
-0.0003579353,
-0.0035065592,
-0.012220017,
0.006539764,
-0.0042944453,
-0.024502316,
0.002494453,
0.012456694,
0.022708552,
-0.0038117482,
0.0069570635,
0.019980537,
0.0018840749,
-0.007567441,
0.00023550936,
-0.034978397,
-0.008065709,
-0.00029292694,
0.010949434,
0.025934836,
-0.0104823075,
0.026433103,
0.0056117405,
0.0065086223,
-0.007878859,
0.002639262,
-0.00010442213,
-0.020105103,
0.0007018568,
-0.026084317,
-0.022297481,
-0.013440772,
-0.015421387,
-0.012120362,
-0.012226244,
-0.039363153,
-0.0129549615,
-0.004166764,
0.03824205,
0.0037681498,
0.0082463315,
0.01827397,
0.0021986065,
-0.03288567,
-0.009678851,
-0.020628285,
0.0055401144,
-0.038217135,
-0.01084978,
-0.007978512,
-0.0051975553,
0.0073619056,
0.011211025,
-0.01397641,
-0.011995796,
0.038042743,
0.18874381,
-0.014474678,
-0.010650473,
0.016903734,
-0.00090388884,
0.0077916617,
0.0006395734,
-0.021761844,
-0.007853946,
0.007953599,
-0.0005188991,
-0.024203356,
-0.005533886,
0.020428978,
0.0073058507,
-0.0072996225,
-0.04878041,
-0.014150804,
-0.011659465,
0.016853906,
-0.010295457,
-0.0040920237,
-0.0049453075,
0.0033197089,
0.01687882,
0.012369497,
-0.015645606,
-0.0011102029,
0.045043405,
-0.015969481,
-0.000467126,
-0.0054030907,
-0.013851843,
-0.004060882,
-0.00002994959,
-0.0022281911,
0.011572268,
-0.026906459,
0.02075285,
0.015620694,
0.006085095,
0.028177042,
-0.011173654,
-0.024925843,
0.025411654,
0.020466348,
0.009130756,
-0.0071376855,
-0.0055370005,
-0.01894663,
-0.0340566,
-0.019918254,
0.008140449,
0.025835183,
-0.008582662,
-0.010339055,
0.009572969,
0.008595118,
-0.02610923,
-0.00048425395,
0.005048075,
0.0051072445,
-0.0086760875,
-0.0029693644,
-0.022060804,
0.021375686,
-0.020541087,
-0.005278524,
-0.0016411694,
-0.031814396,
0.021313403,
-0.020590914,
-0.028575655,
-0.0036062128,
-0.008800654,
-0.0035252443,
0.0022531045,
0.016417922,
0.005770563,
0.027529292,
-0.005717622,
-0.0017501655,
-0.036273893,
-0.0033041378,
-0.019594379,
-0.04235276,
0.011323134,
0.020790221,
-0.022247655,
-0.00058507535,
-0.0154463,
0.006234575,
-0.017950095,
0.024801277,
0.04332438,
0.011497528,
-0.0020880532,
0.005297209,
-0.0044844095,
-0.015421387,
-0.0035159017,
0.072298646,
-0.011921056,
-0.006919693,
0.021363229,
0.012425552,
-0.019581921,
0.012662229,
0.014786095,
0.0054529174,
0.005010705,
-0.029024096,
-0.0017517225,
-0.01397641,
-0.007181284,
0.02678189,
0.0078041186,
-0.006427654,
-0.0035221302,
-0.013627622,
0.011559811,
-0.03413134,
0.005101016,
0.0014278485,
0.011279536,
-0.00067577563,
0.0020242126,
-0.0047989413,
-0.008613803,
-0.04235276,
-0.00042391685,
-0.0054902877,
-0.0077667483,
-0.004528008,
-0.0050418465,
0.01790027,
-0.004054654,
-0.030493986,
-0.020615827,
0.0036404687,
-0.017426914,
-0.01096189,
0.016031764,
0.008707229,
0.03552649,
-0.004465725,
-0.00028922886,
-0.014873292,
0.01691619,
-0.0029911636,
-0.043050334,
0.005801705,
0.01397641,
0.0032979096,
0.020628285,
-0.0182366,
0.00923041,
-0.0073681343,
-0.007990969,
0.0024165986,
-0.02071548,
0.014748725,
0.027778426,
0.008040796,
0.0069259214,
0.013490599,
-0.1531675,
0.03323446,
-0.009442174,
-0.0044470397,
0.002910195,
0.01084978,
-0.0045902915,
-0.0053501497,
0.023817198,
-0.012942504,
0.012724512,
0.0065335357,
-0.012481607,
-0.0032075986,
0.01819923,
-0.0116220955,
-0.004188563,
0.028351434,
0.018211685,
-0.003578185,
0.032387402,
-0.010413796,
0.012300985,
-0.036099497,
0.0050885594,
-0.009753591,
-0.0042259335,
0.030693293,
-0.019519638,
-0.021051813,
-0.040857956,
0.002299817,
0.034754176,
0.000119311764,
-0.025050411,
-0.002084939,
-0.006181634,
-0.04192923,
-0.00097629335,
0.004250847,
0.031341042,
0.041156914,
0.017215151,
-0.0012698042,
-0.018822065,
-0.00029292694,
0.00582039,
-0.0010377982,
0.028226867,
0.021861497,
0.028276695,
0.0037214372,
0.014948032,
0.013415859,
-0.023817198,
-0.0053283507,
0.0044750674,
0.011173654,
-0.01160341,
-0.027006112,
-0.026956284,
-0.029920978,
-0.011248394,
0.020316867,
0.0052006696,
-0.032412317,
-0.028301608,
0.015271906,
-0.020055277,
0.025037954,
0.0027778426,
-0.018448364,
0.0031920278,
-0.010681614,
0.016280899,
0.01020826,
-0.004310016,
0.007847717,
-0.0061567207,
-0.013777103,
-0.012724512,
-0.0139888665,
-0.020179844,
0.012749426,
-0.0027249018,
0.0012986104,
0.01857293,
0.01533419,
-0.0028619254,
-0.03074312,
0.016891276,
-0.025561135,
0.022770835,
-0.0046619177,
-0.010401339,
0.016280899,
0.012232473,
-0.010532134,
-0.002316945,
-0.0035096733,
0.0039051734,
0.009062245,
-0.010426252,
0.0044844095,
0.042178363,
-0.00066604384,
-0.025212348,
-0.011435244,
0.020503718,
-0.0041574216,
-0.016368095,
0.030095372,
0.0077854334,
0.0049141655,
-0.013341119,
0.0062314607,
-0.0048861383,
-0.0077293785,
-0.008146677,
-0.008059481,
0.056702867,
-0.020291954,
-0.008844253,
0.008906536,
-0.005907587,
-0.019532096,
-0.111313015,
0.005266067,
0.028052473,
0.025137607,
-0.0005862431,
0.026009576,
-0.026059402,
0.008707229,
0.007866402,
0.020491261,
0.019855969,
-0.031839307,
-0.000046371988,
0.012207559,
0.057350617,
-0.022459418,
-0.014823466,
-0.043224726,
-0.01578263,
0.02162482,
-0.0049484214,
-0.009946669,
0.015134882,
-0.029223403,
-0.027778426,
-0.039163843,
-0.022123087,
0.024153529,
0.0054311184,
-0.0013608937,
0.013054615,
-0.0005566585,
-0.009124528,
0.005639768,
-0.021350773,
0.00546226,
0.014188174,
-0.021276033,
0.04569115,
-0.028077386,
0.013478142,
0.013390945,
0.01514734,
-0.008271244,
0.013465686,
-0.020989528,
-0.010974347,
0.022098174,
0.0064338823,
0.0139888665,
0.0066082757,
-0.027554207,
-0.0010424695,
-0.018660126,
-0.012624859,
-0.022583986,
0.0073619056,
0.009672622,
-0.0016069135,
0.030344505,
0.0089127645,
-0.0010486979,
-0.02979641,
0.037096035,
0.01816186,
-0.042477325,
-0.0063684843,
-0.025174977,
0.022285026,
-0.030219939,
-0.02030441,
-0.006147378,
-0.008426953,
-0.0077169216,
-0.015533497,
0.010251859,
0.0011452372,
0.0139888665,
0.004437697,
-0.022957686,
-0.007511386,
0.0046432326,
0.0032262837,
-0.011927284,
0.010799954,
0.040857956,
-0.010314142,
0.00064190896,
-0.009473315,
-0.030643467,
0.0020880532,
0.035775624,
-0.0038304334,
-0.002908638,
0.016704425,
0.02305734,
-0.013378489,
-0.006408969,
0.009990268,
0.019345244,
-0.019158395,
-0.017713418,
-0.04863093,
0.019519638,
0.0019728288,
0.012599945,
-0.001831134,
-0.020827591,
0.027927907,
0.0057799057,
0.027604032,
0.02181167,
-0.026159056,
0.023007512,
0.0078601735,
0.0026626182,
-0.012238702,
-0.004705516,
0.030618552,
0.039612286,
0.017190237,
0.014088521,
0.0033321655,
0.0060041263,
0.024153529,
0.02350578,
-0.012942504,
-0.008015882,
-0.019656662,
0.022808205,
-0.00998404,
0.004833197,
0.0010307914,
-0.0141383475,
0.014350111,
0.010108607,
0.008022111,
-0.009828331,
-0.009946669,
0.0059823273,
0.013602709,
0.043897387,
0.023580521,
-0.04053408,
0.0034785317,
-0.014873292,
-0.014873292,
-0.010899607,
-0.029073922,
0.028376348,
0.034828916,
-0.008159135,
0.03228775,
0.0008174705,
-0.03278602,
-0.037619215,
-0.01883452,
-0.0019852854,
0.028152127,
0.0061722915,
0.0025396084,
-0.040932696,
0.02919849,
0.022247655,
0.0057051657,
0.011958426,
0.024813734,
-0.010152205,
-0.019320332,
-0.0029646931,
0.011497528,
-0.016330725,
0.008757056,
-0.01846082,
-0.008813111,
0.0068885516,
0.009292694,
0.0022001634,
-0.015159796,
0.028924443,
-0.0061162366,
0.02640819,
0.020578457,
0.024689166,
-0.03213827,
0.027753513,
0.034380473,
0.013627622,
-0.033284284,
0.02000545,
0.0019479154,
0.005294095,
-0.030444158,
0.023331387,
-0.02158745,
0.01582,
0.015408929,
0.014325198,
-0.0027015454,
-0.020852504,
0.0060975514,
0.017875355,
-0.00517887,
0.0026486046,
-0.046363812,
-0.024253182,
-0.025424112,
-0.008757056,
-0.01081241,
-0.048008095,
-0.032686364,
0.025860095,
0.02166219,
0.025174977,
0.002534937,
0.0038709175,
-0.008794426,
0.006751528,
-0.006396512,
-0.0017875355,
0.0013243023,
0.041231655,
-0.014661528,
0.014300284,
-0.0069944332,
-0.008196505,
0.0079224575,
0.00040289617,
0.0015672077,
0.0074677877,
0.020927245,
-0.00893145,
0.0047335434,
-0.004580949,
-0.037768696,
0.0008384912,
0.009977812,
-0.006521079,
0.033807468,
0.007667095,
0.003786835,
0.047609482,
0.014188174,
-0.012375725,
0.034828916,
0.0011732648,
0.008620032,
0.008277473,
0.0020070847,
-0.0020164272,
-0.029148662,
0.004328701,
-0.02222274,
-0.008769512,
-0.021986064,
-0.0060103545,
0.0140511505,
0.011304449,
0.005568142,
0.018410994,
0.008813111,
0.018373623,
-0.010339055,
0.0016396123,
-0.019868426,
-0.012232473,
-0.007934914,
0.0333092,
0.006570906,
-0.0104387095,
-0.010899607,
-0.0054684887,
0.003073689,
-0.01827397,
0.004166764,
0.009442174,
0.012269843,
-0.001938573,
-0.020740395,
0.024365293,
0.0093425205,
0.004646347,
0.019195765,
-0.025610961,
-0.019220678,
-0.012182646,
0.008582662,
0.017875355,
-0.0198186,
-0.02475145
] |
Leprosy enables investigation of mechanisms by which the innate immune system contributes to host defense against infection, because in one form, the disease progresses, and in the other, the infection is limited. We report that Toll-like receptor (TLR) activation of human monocytes induces rapid differentiation into two distinct subsets: DC-SIGN+ CD16+ macrophages and CD1b+ DC-SIGN− dendritic cells. DC-SIGN+ phagocytic macrophages were expanded by TLR-mediated upregulation of interleukin (IL)-15 and IL-15 receptor. CD1b+ dendritic cells were | [
-0.011899828,
-0.0009141112,
-0.01098244,
-0.041780453,
-0.0048785363,
0.030142736,
-0.01036648,
0.012515788,
-0.028727338,
-0.017967692,
0.0074636033,
-0.004134797,
-0.0032518115,
-0.0000020685375,
-0.0057729892,
0.011342842,
0.038923446,
0.01365597,
0.00009844511,
-0.008151644,
-0.04191151,
0.01261408,
0.0056648683,
-0.023970028,
0.001883921,
-0.0010328802,
0.006421713,
-0.04754689,
-0.023812762,
0.010884149,
0.0003317339,
-0.01438988,
-0.0026391277,
-0.006021994,
-0.018701602,
-0.02170277,
0.031610556,
-0.005746778,
0.019435512,
-0.004842496,
-0.0060482053,
0.0018102024,
-0.0056058937,
-0.017456576,
0.004760586,
0.0026456804,
0.0057336725,
-0.014350563,
-0.022371152,
-0.0016218103,
0.023013324,
-0.023917606,
-0.005576406,
0.017076515,
-0.02463841,
-0.010445113,
0.009213192,
0.022449786,
0.009186981,
-0.047730368,
-0.011205235,
0.0027980322,
-0.020195633,
0.011316631,
0.0035450477,
0.0156218,
-0.0054944963,
0.025778592,
-0.0009992972,
0.014665096,
0.0473372,
0.024861204,
0.0015865891,
0.0044460534,
0.015045157,
-0.01914719,
-0.007135965,
0.011434581,
0.0062120245,
0.0023589968,
0.010045394,
-0.014285035,
-0.025621325,
0.00016300012,
0.012594421,
-0.009534278,
-0.009652228,
0.004416566,
0.00615305,
-0.028753549,
0.0074177342,
-0.00037432692,
0.031427078,
0.030142736,
-0.0027669065,
0.02425835,
0.0016504786,
0.02123097,
-0.0070114625,
-0.02733815,
-0.030116525,
-0.0009100157,
-0.014494725,
-0.01594944,
-0.014101558,
0.007791242,
-0.0019985945,
0.0016242675,
0.02137513,
-0.011559084,
-0.025804803,
0.028124483,
0.009599806,
-0.04998452,
0.03362881,
-0.0029765952,
-0.0041282442,
0.007168729,
0.0009567042,
0.00041343874,
0.032396886,
0.021008177,
-0.011683586,
-0.00317154,
0.02980199,
0.012502682,
-0.018727813,
-0.001747951,
-0.027233306,
-0.0030159117,
0.0050652903,
0.01195225,
-0.0005217642,
0.007024568,
0.0036793796,
0.0066445074,
-0.0070442264,
0.006290658,
-0.02473015,
-0.00634308,
0.009272167,
0.025647536,
0.007306337,
-0.013400412,
0.037848793,
0.02608002,
0.029670937,
0.012319205,
-0.013131748,
0.016198443,
-0.001645564,
-0.03001168,
0.006762457,
-0.033104587,
0.0043510385,
0.015503851,
-0.009226298,
0.039735988,
0.0010443475,
-0.01891129,
-0.00859068,
-0.030142736,
0.0043575913,
0.0063365274,
0.021113021,
0.029172925,
0.02399624,
0.032292046,
0.009973314,
0.0041741137,
-0.01017645,
0.032816265,
-0.009626017,
0.02622418,
-0.010163344,
0.004606596,
0.0002395856,
0.00018890403,
-0.008492388,
-0.019094767,
0.0074439454,
0.016814405,
0.010104369,
0.0019969563,
-0.007601212,
-0.012522341,
0.029120503,
0.0028750272,
-0.0013695286,
-0.014311247,
0.002608002,
0.022502208,
-0.0076601864,
-0.021925563,
-0.6336789,
-0.021912457,
0.0096391225,
0.012207808,
-0.011821195,
0.011244551,
0.01905545,
-0.024559777,
-0.012227466,
0.01512379,
-0.005992507,
-0.007968167,
0.012528894,
-0.030824224,
-0.015779067,
-0.022043513,
-0.013800131,
-0.0069262763,
0.022672579,
-0.011185576,
-0.018360857,
-0.013249698,
0.0038595807,
-0.00015409246,
-0.01758763,
-0.0017299309,
0.019566568,
-0.011015204,
-0.0049211294,
0.04799248,
-0.012522341,
0.004321551,
0.012266783,
-0.0138525525,
0.053260904,
-0.0014055689,
-0.010510641,
0.048411854,
0.005501049,
0.030378636,
-0.024834992,
-0.0027685447,
-0.0027488864,
-0.0028848564,
-0.03250173,
0.022331836,
-0.0055305366,
0.03635476,
0.0055534714,
-0.010300952,
0.013721498,
0.010556511,
-0.01275824,
0.0058155823,
0.047651734,
0.0013162874,
0.022711895,
-0.008951082,
0.0018822828,
-0.0038497515,
-0.016919248,
-0.0013441367,
0.0034500328,
-0.026892563,
-0.022279413,
0.009468751,
-0.023537545,
-0.015150001,
0.011316631,
-0.0007343196,
0.022764318,
0.031060124,
0.00024695747,
0.020090789,
-0.0097308615,
0.032580364,
-0.018452596,
0.007935403,
-0.0042134305,
0.0068083266,
-0.0018609863,
-0.013564231,
-0.015844595,
0.005071843,
0.021833826,
-0.009626017,
0.00797472,
0.009226298,
-0.016224654,
0.007057332,
0.002974957,
0.010006078,
-0.025739275,
-0.04416566,
-0.021558609,
0.031138757,
-0.011755667,
-0.009802942,
-0.02452046,
0.0029307257,
-0.00870863,
-0.008145091,
0.012810662,
0.006248065,
0.044768516,
-0.012011225,
-0.0321872,
-0.008610338,
0.05090191,
-0.0331308,
-0.005022697,
-0.00032579547,
-0.0018429662,
-0.002567047,
-0.0040102946,
-0.011113496,
0.012633738,
0.0021886248,
0.007882981,
-0.021270286,
0.027442995,
0.011296974,
0.010798963,
-0.017128937,
0.00031248515,
0.009304931,
-0.0022820018,
0.0003137138,
0.0048556016,
-0.031977512,
0.0044460534,
-0.000010341088,
0.0010984079,
-0.028072061,
0.025097104,
0.02478257,
0.02927777,
-0.009318037,
-0.0058942153,
-0.038373012,
-0.036721714,
-0.021453764,
0.01843949,
-0.018138064,
-0.007850217,
-0.0063529094,
-0.002684997,
-0.006493794,
-0.0059728487,
-0.0096391225,
0.014887891,
-0.003915279,
-0.012365075,
0.0009116539,
0.016893037,
-0.00676901,
0.004432948,
-0.0077191615,
0.0017102726,
-0.016866826,
-0.018373962,
0.009121454,
-0.0004636084,
0.014153981,
-0.009114902,
-0.02096886,
0.012437155,
0.007496367,
0.015202424,
-0.048909865,
0.010549958,
-0.012764793,
-0.016735772,
0.010287846,
0.0026997407,
0.009580147,
-0.012541999,
-0.008806921,
-0.0042265356,
0.0044722646,
0.008426861,
-0.012227466,
0.014783046,
-0.004144626,
0.02293469,
-0.0020854187,
0.015032051,
-0.0006077693,
0.026014492,
0.047389623,
-0.014363669,
0.010890702,
-0.0020411874,
0.0139442915,
0.009023163,
-0.012830321,
0.019632095,
0.027652683,
0.0107465405,
0.011886722,
-0.023000218,
-0.02252842,
0.012705819,
-0.02877976,
0.00214767,
-0.023065746,
0.004239641,
-0.033786073,
0.03074559,
0.00951462,
0.0053568883,
-0.002812776,
-0.0027325046,
0.008800368,
0.0023426148,
0.04437535,
0.011867064,
0.0021787956,
-0.019985944,
-0.02537232,
0.003954596,
0.007830558,
0.01547764,
-0.02137513,
-0.011336289,
0.00545518,
0.018098747,
0.01152632,
-0.016290182,
-0.009829153,
-0.002295107,
-0.020785382,
0.019396195,
0.019369984,
0.0016013328,
0.011971909,
-0.015412112,
0.010458219,
0.013878764,
0.0016717751,
0.0016267248,
0.022187674,
0.004314998,
0.0028684745,
-0.019579673,
0.0060907984,
-0.007535684,
0.003076525,
-0.019802466,
0.020392217,
-0.0030634194,
-0.006556045,
-0.02252842,
-0.0014285035,
-0.00005539137,
-0.0061268387,
0.0064577535,
0.009318037,
0.03653824,
0.01098244,
0.02061501,
-0.009298379,
0.008983846,
-0.039604932,
0.018937502,
0.0036957616,
-0.00078633224,
-0.016919248,
0.00062456075,
-0.0062775523,
-0.030824224,
0.009842259,
0.008937976,
-0.030693168,
-0.018216697,
0.016014967,
0.013747709,
-0.0083482275,
0.021126127,
0.007987825,
-0.0062447884,
-0.028832182,
0.029303981,
0.02182072,
-0.0026964643,
-0.031138757,
-0.033497754,
-0.00022811825,
0.0052880845,
0.0001827608,
0.020287372,
0.0131448535,
0.02255463,
0.011414923,
-0.0034041633,
-0.010700671,
0.023314752,
-0.018596757,
0.010903807,
-0.001269599,
0.0148354685,
0.0036629976,
-0.022056619,
-0.026315918,
0.038451646,
-0.0024966048,
-0.0046164254,
-0.0088724485,
-0.025490269,
-0.03459862,
0.0017364837,
0.0055960645,
0.0082827,
-0.027023617,
0.02449425,
0.016185338,
0.0010885787,
0.011506662,
0.016630927,
0.007830558,
-0.01794148,
-0.05050874,
0.010641696,
-0.00429534,
0.018308435,
0.03394334,
0.0047966265,
0.026171759,
-0.010373033,
0.0012802471,
-0.0059794015,
-0.023301646,
0.036721714,
-0.009979866,
-0.013216934,
0.011467345,
-0.0072801257,
0.023537545,
0.020130105,
0.024350088,
0.01668335,
0.0021771574,
-0.00033685326,
0.00014866593,
-0.0054944963,
0.007876428,
0.030378636,
0.021624137,
0.024363194,
-0.013053115,
0.0058450694,
0.0073128897,
-0.0080402475,
-0.020366006,
-0.0040201237,
0.006860749,
-0.00299953,
0.013406965,
-0.016014967,
-0.015897017,
-0.009953655,
0.006251341,
0.014232613,
-0.004590214,
0.020366006,
0.01843949,
0.006657613,
-0.00061800797,
0.0048228377,
0.0076929503,
0.0024228862,
0.020981966,
0.012011225,
-0.01453404,
0.042252254,
-0.02220078,
-0.01202433,
-0.021781404,
0.00081704836,
-0.011506662,
-0.004223259,
-0.007941956,
-0.008177855,
0.008741394,
-0.011794983,
-0.020444639,
0.022226991,
-0.010418902,
-0.02241047,
-0.015307267,
-0.0058942153,
0.0036761032,
-0.035542216,
0.010045394,
0.0020313582,
-0.014285035,
-0.014101558,
0.0107465405,
0.0024556501,
0.010373033,
0.015176212,
0.011369053,
0.032790054,
0.033235643,
-0.0034991784,
-0.015136896,
0.009285273,
-0.03507042,
0.046996456,
0.013085879,
0.016722666,
0.004970275,
-0.021191653,
-0.0056746975,
0.008669313,
-0.0023655496,
0.010110922,
0.0058155823,
-0.013577336,
0.02525437,
0.020208739,
0.012443707,
-0.023091957,
-0.020693643,
-0.0069721458,
-0.029985469,
-0.012974482,
0.00970465,
-0.01273203,
-0.03391713,
0.0009018248,
0.011500109,
-0.016408132,
-0.010241977,
0.031427078,
-0.02754784,
-0.0029307257,
-0.0052192803,
0.013747709,
0.030352425,
0.0068476433,
0.0010066691,
0.025804803,
-0.036197495,
-0.027495418,
-0.015608694,
0.029566092,
0.0024605647,
-0.033864707,
0.0004808094,
-0.0035188368,
-0.0029290875,
-0.003794053,
-0.0243763,
-0.019605884,
0.00665106,
0.009010057,
-0.013603548,
-0.011532873,
0.012365075,
0.0035745353,
-0.00014303465,
-0.014547146,
-0.01843949,
-0.0027816503,
-0.0005225833,
0.0046098726,
-0.010183003,
0.033314276,
-0.030326214,
-0.013361095,
0.02179451,
-0.0019052175,
0.0148354685,
-0.022882268,
0.012083305,
-0.016840616,
0.0048785363,
-0.014992734,
-0.01720757,
0.008741394,
-0.019894205,
0.054938413,
0.0074111815,
0.012358522,
-0.014900995,
0.03504421,
0.010622038,
-0.0034500328,
-0.008826579,
-0.006349633,
0.0041544554,
-0.016263971,
0.0077453726,
2.8636367e-7,
-0.0042330883,
0.006592085,
-0.010766199,
0.00502925,
0.00479335,
-0.018622968,
-0.019278245,
-0.014022925,
-0.031296022,
-0.03074559,
0.0068345377,
-0.008105774,
-0.00029036956,
-0.038504068,
0.0069786985,
0.045476213,
-0.008426861,
0.005795924,
0.014402986,
0.024559777,
-0.016958565,
0.03805848,
-0.013210381,
0.013105537,
0.010812068,
0.00023835695,
-0.0054322453,
0.0104385605,
-0.0018806446,
0.004606596,
-0.015936334,
0.032108568,
-0.005157029,
0.010418902,
-0.0017725239,
-0.009508068,
-0.03779637,
-0.024035556,
-0.028753549,
-0.016277077,
-0.013459386,
-0.005615723,
-0.021650348,
-0.00027316855,
-0.006356186,
-0.0058450694,
0.014586463,
-0.018138064,
-0.018334646,
0.038923446,
-0.0060809692,
0.010261635,
-0.027521629,
0.012148833,
0.006192366,
0.009488409,
-0.025411637,
0.014402986,
-0.0008911765,
-0.0062611704,
0.034939364,
0.025385426,
-0.034310296,
-0.0010664631,
0.0118343,
-0.001321202,
-0.001202433,
-0.022515314,
0.022030408,
0.008715183,
-0.008249936,
-0.01311209,
-0.015897017,
-0.022226991,
-0.005966296,
-0.019841783,
0.0066182963,
-0.0038399224,
0.0018396898,
-0.003096183,
0.018780235,
-0.011624612,
-0.0008551363,
-0.0058974917,
-0.013721498,
-0.009128007,
-0.037219726,
0.012456813,
-0.006038376,
-0.021152338,
0.026971195,
0.0077781365,
0.015726645,
0.016552294,
0.015320373,
0.015307267,
0.008695524,
-0.007765031,
0.04392976,
-0.005736949,
0.005347059,
0.009167323,
0.013642864,
-0.008079563,
-0.01594944,
-0.007306337,
0.001406388,
-0.024769465,
-0.013983608,
0.017928375,
-0.0154514285,
-0.014285035,
0.026381446,
-0.027207095,
-0.008387544,
-0.0053601647,
-0.019199612,
0.024323877,
-0.023327855,
0.011578742,
0.004003742,
0.003384505,
0.035149053,
0.026787719,
0.015765961,
-0.0066772713,
0.024114188,
-0.02625039,
0.007699503,
-0.0022361323,
0.007332548,
-0.0071490705,
-0.0043936316,
0.015883911,
-0.042986162,
0.023773445,
-0.009868469,
-0.026669769,
-0.024310771,
-0.0015915037,
-0.014206402,
0.008839685,
-0.015254845,
0.027023617,
-0.013996714,
0.026499396,
0.000028335606,
-0.0014334181,
0.033523966,
-0.008715183,
-0.010458219,
0.02551648,
-0.002404866,
-0.014730624,
0.018937502,
0.0039513195,
-0.00494734,
-0.02182072,
-0.027574051,
-0.026001386,
-0.007083543,
-0.02317059,
-0.009291826,
-0.008924871,
-0.00073718646,
-0.013262804,
0.00533723,
-0.0053568883,
-0.020064577,
0.00359747,
-0.008131986,
-0.0048719835,
0.010766199,
-0.01001263,
0.008505493,
0.01815117,
-0.014442302,
-0.027180884,
-0.012030883,
-0.03797985,
0.035516005,
-0.028098272,
0.0065953615,
0.0038825155,
0.022095935,
-0.046183914,
-0.019448617,
-0.009606359,
0.009973314,
0.0010246892,
0.0063103163,
-0.0057926476,
0.0039185556,
0.0004767139,
0.014311247,
-0.017142043,
-0.02513642,
0.0019887653,
-0.0030486756,
0.020405322,
0.00920664,
-0.021335814,
-0.008951082,
0.037245937,
-0.009521172,
-0.0050259735,
0.022030408,
-0.012954824,
-0.005543642,
-0.0020592075,
0.008688971,
-0.008066459,
0.01292206,
0.025385426,
0.0029094294,
0.012974482,
0.014730624,
0.014350563,
-0.022253202,
-0.016028073,
0.00058524415,
0.018701602,
0.0039939126,
-0.0070769903,
-0.033995762,
0.014101558,
-0.016421238,
0.018478807,
0.004527963,
-0.011310078,
0.015084473,
-0.012961376,
-0.023734128,
-0.023118168,
0.0007859227,
-0.033261854,
-0.0038595807,
0.0011262571,
-0.0041216915,
-0.019212717,
-0.008466177,
0.01024853,
-0.025896542,
0.0077191615,
-0.015320373,
0.011480451,
-0.041413497,
0.019723834,
0.016539188,
-0.033523966,
-0.012646844,
-0.0059859543,
-0.027888583,
-0.032108568,
-0.004550898,
0.019841783,
-0.01304001,
-0.010956229,
0.0019543632,
0.0009878299,
-0.006326698,
-0.011663928,
-0.014796152,
-0.009848812,
0.011487003,
0.18892942,
-0.045240313,
0.001774162,
0.007529131,
-0.0025539417,
0.016408132,
0.0077846893,
-0.008125433,
-0.01377392,
0.0049047475,
0.03166298,
-0.007837111,
0.00688696,
0.0047114408,
0.012659949,
-0.013459386,
-0.008839685,
-0.005720567,
-0.005124265,
-0.017168254,
0.022030408,
-0.015399006,
0.00039111837,
-0.02317059,
0.033078376,
0.008924871,
-0.019252034,
0.0033533794,
0.01803322,
-0.0010255083,
-0.039080713,
0.008367886,
-0.007332548,
0.0050652903,
-0.0032534497,
0.0014162171,
-0.009304931,
-0.016080495,
0.010333716,
0.0017266546,
0.025057787,
-0.011355948,
-0.035568427,
0.008000931,
-0.018505018,
0.02669598,
0.004714717,
-0.010307505,
-0.005635381,
0.013983608,
-0.020995071,
-0.0063627386,
-0.0018560718,
0.0050161444,
-0.0070180153,
-0.009691545,
0.018688496,
0.01900303,
-0.00975052,
0.03396955,
-0.008413755,
0.016041178,
-0.02402245,
0.023812762,
-0.018950608,
0.031060124,
-0.009272167,
0.010117475,
0.00014518478,
-0.02170277,
-0.0021706047,
-0.016224654,
-0.01334799,
-0.002275449,
-0.011808089,
-0.02208283,
0.01864918,
-0.014848574,
0.034546196,
0.021453764,
0.025306793,
0.0072801257,
-0.032370675,
-0.001602971,
-0.0059302556,
-0.034231663,
0.036197495,
0.009154217,
-0.021768298,
0.000639714,
0.007260468,
-0.0027849267,
-0.017495893,
-0.021768298,
0.009481857,
-0.0017020816,
-0.00157676,
-0.0033353593,
0.010949676,
-0.03024758,
-0.026499396,
0.09247267,
0.0047409283,
-0.023825867,
-0.022659473,
0.03897587,
0.0033910577,
0.006723141,
0.015281056,
-0.013007246,
0.023039535,
-0.015110685,
0.01032061,
0.0003341912,
-0.0020493784,
0.03150571,
0.011722903,
0.003104374,
0.0029176201,
-0.0055731297,
0.0047507575,
-0.01427193,
-0.013334884,
0.02376034,
-0.010104369,
0.0054977727,
-0.015032051,
0.025333004,
0.0030535902,
-0.017050304,
-0.018740918,
-0.0100585,
-0.008905212,
0.02399624,
0.0106548015,
0.01353802,
0.0093311425,
-0.026512502,
-0.03735078,
0.0045541744,
-0.018098747,
-0.008079563,
0.009291826,
0.004210154,
0.010687565,
0.003384505,
0.014219508,
0.0191734,
-0.0104385605,
0.0034238216,
-0.0036236811,
-0.020483954,
-0.0009837344,
0.00030060826,
0.013177617,
-0.016775088,
-0.017613841,
-0.00003365973,
0.01697167,
0.008944529,
-0.011382159,
0.006264447,
-0.0043248273,
-0.022043513,
-0.0008928147,
0.010228871,
-0.16345227,
0.014547146,
0.0138525525,
-0.013433176,
0.029094292,
0.021663453,
-0.00927872,
-0.009036268,
0.00006153459,
0.005297913,
0.03711488,
0.006991804,
-0.017076515,
0.0057828184,
0.0043772496,
-0.014022925,
0.004858878,
0.037219726,
0.034231663,
0.006965593,
0.028753549,
-0.038687546,
-0.021807615,
-0.017312415,
0.009875022,
0.022423575,
0.014206402,
0.009193534,
0.0005561662,
-0.028884605,
0.003931661,
0.0046688477,
0.032265835,
-0.0061727082,
0.02137513,
0.013177617,
0.009226298,
0.008276147,
0.00039930933,
0.023105063,
0.039316613,
0.0039087264,
0.019920416,
-0.006736246,
-0.018400174,
0.013118642,
-0.00082401064,
-0.01048443,
0.004541069,
-0.017168254,
0.02707604,
-0.023039535,
0.0040725456,
0.029461248,
0.01864918,
0.015648011,
0.0036204048,
0.01391808,
-0.012332311,
0.009606359,
0.008217172,
-0.015490745,
0.027626473,
0.014704413,
0.028648704,
-0.028412804,
0.0061956425,
0.012483024,
-0.016381921,
0.016735772,
-0.022161463,
-0.020575693,
0.0014727347,
-0.034782097,
0.018858869,
0.03483452,
-0.008721735,
-0.0055534714,
-0.0050751194,
0.009449093,
-0.0014285035,
0.00031084695,
-0.015805278,
0.004219983,
-0.024585988,
-0.008217172,
-0.012699266,
0.0069786985,
0.0147437295,
-0.01644745,
0.011559084,
-0.036380973,
0.0070769903,
-0.015582484,
0.017364837,
0.049932096,
-0.013498703,
-0.002498243,
-0.026289707,
0.0026211075,
-0.009671886,
-0.02293469,
-0.014665096,
0.011421476,
-0.0022983835,
-0.02428456,
-0.015661117,
-0.021479975,
0.025699958,
-0.006860749,
-0.0025850672,
0.00097390526,
0.009920891,
0.023917606,
-0.010949676,
0.014796152,
0.0043510385,
-0.00018982551,
-0.005117712,
-0.02052327,
0.07307648,
-0.009966761,
-0.026892563,
0.027128462,
-0.0060056127,
-0.02972336,
-0.13933808,
-0.000082012,
0.005294637,
-0.007083543,
-0.03543737,
0.017784214,
-0.004737652,
-0.00084694533,
-0.012017778,
0.010739988,
-0.0074504977,
-0.010189556,
-0.0012515788,
-0.015726645,
0.00332553,
-0.0037285252,
-0.004007018,
-0.00994055,
-0.030929068,
0.036800347,
-0.011120048,
-0.013269356,
0.011578742,
-0.00007842845,
0.007188387,
-0.0038464752,
-0.02625039,
0.033288065,
-0.010143686,
0.022803634,
0.01330212,
-0.0033484648,
0.012332311,
0.0064315423,
-0.021925563,
0.010065053,
-0.0040102946,
-0.0093311425,
0.021755192,
-0.0062382356,
0.0011319908,
0.012961376,
0.0032583643,
0.005795924,
0.0019068556,
-0.008616891,
-0.01377392,
0.0025703234,
0.026735296,
-0.029880624,
-0.017338626,
-0.02608002,
-0.034913152,
-0.009901233,
0.012443707,
-0.0037383544,
-0.013066221,
0.033445332,
-0.023616178,
-0.013616653,
0.007339101,
0.003554877,
-0.0030421228,
0.010137133,
0.036040228,
-0.031348445,
0.008964187,
-0.011559084,
0.010202661,
-0.015765961,
0.011722903,
-0.0319513,
-0.009835706,
0.00077158853,
-0.0025424743,
0.015818384,
-0.014822363,
-0.024979154,
-0.009573595,
-0.021938669,
-0.029592304,
-0.007273573,
0.020654326,
-0.01670956,
0.045764536,
-0.0050259735,
0.0014022925,
0.001499765,
0.010536852,
-0.0051635816,
-0.009475304,
0.04859533,
0.005094778,
0.0046655713,
-0.003554877,
0.02731194,
-0.017613841,
-0.0021263734,
0.01914719,
0.019330667,
-0.0062284064,
-0.006998357,
-0.04340554,
0.01900303,
-0.016028073,
0.00014016782,
0.0194093,
-0.016552294,
-0.0062972107,
-0.021571714,
0.02073296,
0.039080713,
-0.025975175,
0.015634906,
-0.010995545,
0.032658998,
-0.02906808,
-0.043274485,
0.019645201,
0.010445113,
0.007955061,
0.027941005,
0.0075750006,
-0.010857938,
0.0036072992,
0.025267476,
-0.020562587,
0.004416566,
0.000490229,
0.015726645,
0.0009329504,
-0.010353374,
-0.0035778116,
-0.03879239,
-0.013695287,
0.0067034825,
-0.019068556,
-0.036957614,
-0.0109300185,
0.04295995,
0.008643102,
0.036249917,
-0.005039079,
-0.041570764,
-0.006169432,
-0.011061073,
0.0000512191,
-0.013878764,
-0.021388236,
0.02731194,
-0.00695904,
-0.02660424,
0.024323877,
0.016119812,
-0.019343773,
-0.023314752,
-0.01594944,
0.015372795,
0.01841328,
-0.014298141,
0.014429197,
-0.031531923,
0.020221844,
0.032423098,
0.020392217,
0.023603072,
-0.0011139706,
-0.023354067,
-0.01841328,
0.02731194,
-0.01729931,
-0.009363906,
-0.015569379,
-0.00007929874,
-0.0018626244,
-0.0052291094,
0.023891395,
0.008249936,
-0.01753521,
-0.004980104,
-0.02974957,
0.021204758,
-0.006556045,
-0.00070606085,
-0.024887415,
0.0024654793,
0.029906835,
0.016146023,
-0.014363669,
0.029670937,
-0.0065396633,
0.0072866785,
0.005471562,
0.017574526,
0.020090789,
0.002131288,
0.035149053,
0.027705105,
0.0054355217,
0.0034926257,
0.011224893,
0.023773445,
0.018845763,
-0.012981035,
0.000266411,
-0.02596207,
0.008505493,
0.0153596895,
-0.05105917,
-0.0397622,
-0.012902401,
0.013524914,
0.018858869,
0.010169897,
-0.011755667,
-0.0022443233,
-0.03098149,
0.0059204265,
0.0070376736,
-0.0019052175,
-0.024428722,
0.030142736,
0.012791004,
0.010340269,
0.001798735,
-0.004524687,
-0.006477412,
0.0010238701,
0.027626473,
-0.02399624,
0.031767823,
0.014927207,
0.013197276,
0.010327163,
-0.034729674,
-0.013616653,
-0.013865658,
-0.0116704805,
0.028098272,
0.039473876,
-0.016906142,
0.08492388,
0.010903807,
-0.029225348,
0.013190723,
-0.039080713,
0.016893037,
0.016866826,
0.010871043,
0.009567042,
-0.02402245,
0.032344464,
-0.0067493515,
0.027914794,
-0.026682874,
-0.04707509,
0.009226298,
-0.018714707,
-0.0034303744,
0.004835943,
-0.015412112,
0.019448617,
0.00634308,
0.0060482053,
0.018400174,
-0.032292046,
0.0015906846,
0.026748402,
-0.00083343027,
-0.007640528,
-0.023524439,
0.013865658,
0.00622513,
-0.0314795,
-0.010065053,
0.0010353375,
-0.008263041,
-0.02085091,
-0.03486073,
-0.009888127,
0.000712204,
-0.009678439,
0.028910816,
-0.027626473,
-0.017037198,
0.0118539585,
-0.002336062,
-0.007358759,
-0.013616653,
-0.008276147
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.