text
stringlengths 174
850
| embeddings_A
sequence |
|---|---|
The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-transforming activity is controlled by GSK-3-dependent phosphorylation and that phosphorylation by GSK-3 can increase the oncogenic activity of a protein. Using microarray analysis, we identify a gene-expression subprogram regulated by GSK-3-mediated Maf phosphorylation involved in extracellular matrix remodeling and relevant to cancer progression. | [
-0.02921886,
-0.030307926,
0.006663892,
-0.040322024,
-0.018952414,
0.014861775,
-0.010027382,
0.0063783443,
-0.018514132,
-0.01706647,
0.04191578,
-0.0077629196,
0.01696022,
0.003841616,
-0.018514132,
-0.014941462,
0.024185246,
-0.009150815,
-0.030812616,
0.0073113553,
-0.03299075,
0.028182918,
-0.025393846,
-0.04823768,
-0.01348716,
0.033893876,
-0.0002288949,
-0.031848557,
-0.013301222,
-0.021263361,
0.011189495,
-0.016455531,
0.002523447,
0.006086156,
-0.003771889,
-0.018421162,
0.009994178,
-0.019935232,
-0.0035693492,
-0.0051099802,
0.008619564,
0.014503179,
-0.0050800974,
-0.019749293,
0.0016053771,
-0.0067601814,
0.03779858,
-0.020479765,
-0.032671995,
0.044997044,
0.0147289615,
-0.005740842,
-0.0049306825,
-0.007942217,
0.0077429977,
-0.018434444,
0.027000882,
0.03237981,
-0.009662146,
-0.003771889,
-0.004509001,
-0.003310364,
-0.0251415,
0.005179707,
0.014224272,
0.01563209,
0.008055109,
0.0048808777,
0.0044060713,
-0.0146625545,
0.057906467,
0.021794613,
-0.0120195765,
-0.006265453,
0.0063119377,
-0.015804747,
-0.02943136,
0.017929755,
-0.009881287,
0.0038084127,
0.024291497,
0.015539121,
-0.00062007067,
0.008048467,
0.005548263,
-0.0065543214,
0.0036955217,
0.016707875,
0.00991449,
0.0029783314,
0.02083836,
0.007351199,
0.020479765,
0.026642287,
-0.020386795,
0.0019971754,
-0.0030115347,
0.025354002,
0.024371184,
-0.013500441,
-0.013799271,
0.009004721,
0.0023059656,
-0.019616479,
-0.030095425,
-0.0026413184,
0.023082899,
-0.007337918,
0.0136000505,
0.00082219543,
-0.026496192,
0.04446579,
0.019443823,
-0.035620447,
0.017345378,
-0.011561371,
0.02034695,
-0.0012841356,
0.008347297,
0.0104590235,
-0.0026313574,
0.04361579,
0.018567257,
-0.0061359606,
0.018102411,
0.013420753,
-0.00030401725,
-0.005946702,
-0.019164916,
0.006979323,
0.04356266,
0.026443068,
0.024769625,
0.009429723,
-0.035142317,
0.00398439,
-0.017916473,
-0.019802418,
-0.016150061,
-0.04414704,
-0.001113139,
0.023414932,
-0.008911752,
-0.0067701424,
-0.0183946,
-0.00055241905,
0.02320243,
0.0011853559,
0.0015240292,
-0.0057972874,
0.01889929,
-0.018128974,
0.015393026,
0.005508419,
-0.005129902,
-0.0056379116,
-0.00051340525,
0.03065324,
-0.037347015,
-0.0048775575,
0.021648519,
0.021170393,
0.013825833,
0.012504344,
0.011900045,
0.026828226,
0.0049638855,
0.0010716348,
-0.0073312772,
-0.022817273,
0.010193397,
0.0074242465,
-0.049406435,
0.0072117457,
-0.01175395,
0.018248506,
-0.0023823332,
0.014210991,
-0.02943136,
0.003924624,
-0.0059998273,
0.005232832,
0.021728206,
-0.0028488387,
-0.008114874,
-0.013932084,
0.032300122,
-0.020718828,
-0.01042582,
-0.027864167,
0.011740669,
0.023919621,
0.011900045,
-0.0045920094,
-0.6319774,
-0.015977403,
0.020054763,
-0.029271984,
0.012079342,
0.023667276,
0.016641468,
-0.016335998,
-0.0077429977,
0.024291497,
-0.024477435,
0.01174731,
0.0027309672,
-0.029059485,
-0.019908668,
-0.04791893,
-0.008194562,
-0.037267327,
0.029856361,
0.012112546,
-0.030520426,
-0.0004914081,
0.0005117451,
0.03219387,
-0.013022315,
0.014503179,
0.034823567,
-0.025168063,
0.008772299,
0.03147668,
-0.029245421,
0.026788382,
-0.0002994518,
0.006673853,
0.038754832,
-0.02013445,
-0.012145748,
0.029298548,
0.008812143,
0.015990686,
-0.007842608,
-0.008134796,
0.023866495,
0.0012534227,
-0.022697741,
0.009848083,
0.0032373169,
0.018925851,
0.004220133,
-0.0041968906,
-0.016455531,
0.008978158,
-0.02289696,
-0.022923524,
0.0018461007,
0.03628451,
0.02828917,
-0.02553994,
0.007530497,
-0.0108309,
0.0076301065,
0.023667276,
0.0010459024,
-0.012066061,
0.008825423,
0.0061060777,
0.004283219,
0.01900554,
-0.0045853686,
0.018447725,
0.021714926,
0.00828089,
-0.0014601129,
0.0019689526,
0.0021001054,
0.024756342,
-0.009031284,
0.013009033,
-0.0009072788,
-0.00044077315,
0.019988356,
0.015977403,
-0.03729389,
-0.00009997291,
0.01870007,
-0.0036091933,
-0.024929,
0.010611759,
0.015459433,
-0.005405489,
0.014675836,
-0.011295745,
-0.01593756,
-0.04733455,
-0.014569586,
-0.0012584032,
0.006617408,
0.024397748,
0.032034494,
-0.038064204,
-0.0147289615,
-0.012809814,
0.0034763801,
-0.000981156,
0.020054763,
-0.010877385,
-0.03689545,
0.014436773,
0.029086046,
-0.01799616,
-0.014264116,
0.018434444,
0.012305124,
-0.029351672,
-0.00817464,
-0.018766476,
0.02892667,
0.0009728552,
0.0017381901,
-0.015512558,
0.0119531695,
0.016322717,
0.00015564023,
0.0021283282,
0.031609494,
0.019988356,
0.01636256,
-0.015100838,
-0.0013945365,
-0.017106313,
0.013194971,
-0.008513313,
0.021701643,
-0.02176805,
0.04106578,
0.009622302,
0.009443004,
0.024437591,
0.02860792,
-0.019935232,
-0.018354757,
-0.0045654466,
0.00058064185,
-0.0074043246,
0.00063086173,
-0.0087457355,
-0.006062913,
0.004180289,
0.014064896,
0.011999655,
0.016920377,
0.0006686304,
0.010160195,
-0.0060230694,
0.043403286,
-0.018221943,
-0.0011015178,
-0.010532071,
-0.015791465,
-0.01665475,
-0.0029102648,
0.009124253,
-0.015844591,
-0.018421162,
-0.0035427867,
-0.0063451407,
-0.0068996353,
0.014277397,
-0.0132813,
-0.033097,
-0.004479118,
-0.031343866,
-0.022206333,
0.008241046,
-0.008679329,
0.007165261,
0.013440675,
-0.0044591962,
-0.00888519,
-0.03251262,
0.005139863,
-0.008114874,
-0.022471959,
-0.006418188,
0.047254864,
0.022193052,
0.022671178,
-0.00021893393,
-0.003649037,
0.033203248,
-0.05190332,
0.009715271,
-0.011468402,
0.018248506,
0.0057707247,
-0.026217286,
0.01297583,
0.015565683,
-0.011973091,
0.023056336,
0.009469567,
-0.011654341,
0.008546516,
0.009110971,
0.015618809,
-0.026350098,
0.0025300875,
-0.018832883,
-0.0031410274,
0.0013405812,
-0.0058138887,
0.016535219,
-0.01593756,
-0.009429723,
-0.0021631918,
0.010644962,
-0.011315667,
0.0069062756,
-0.019988356,
-0.0062488513,
0.0017282291,
0.011993013,
0.017332096,
-0.0077828416,
-0.0051365425,
0.024982125,
0.009164097,
0.033097,
0.0028654404,
-0.004240055,
-0.0053091994,
0.018341474,
0.003821694,
0.013294581,
0.009031284,
-0.002491904,
-0.0041670077,
-0.019018821,
0.051372066,
-0.014968025,
-0.0004474138,
0.009735193,
0.0047049006,
-0.00024777924,
-0.00080393365,
-0.015539121,
0.025659472,
-0.009635583,
-0.0019556715,
0.014954744,
-0.019682886,
0.028209481,
0.010186757,
0.014476617,
0.0054088095,
-0.014649274,
-0.0019440502,
0.01605709,
0.035301693,
0.018660227,
-0.012351609,
-0.0015647031,
-0.00069851335,
-0.0026396583,
0.00684651,
0.00889183,
0.014503179,
-0.0037851704,
-0.0065775635,
-0.0059898663,
-0.02430478,
0.00296173,
0.017119596,
-0.035779823,
0.014277397,
0.013294581,
0.0009321812,
0.026482912,
0.015685216,
0.017943036,
-0.008433625,
-0.04098609,
0.013533644,
0.01460943,
-0.012145748,
-0.007756279,
-0.017929755,
0.0031924925,
0.00062173087,
0.033654813,
0.0056445524,
0.008705892,
-0.018036004,
0.003595912,
-0.01889929,
-0.017212564,
0.017079752,
-0.0026629006,
0.01185356,
-0.012358249,
-0.007643388,
0.0025931739,
-0.017119596,
-0.0024653412,
0.03362825,
0.006292016,
0.009741833,
-0.0043595866,
-0.0068929945,
-0.04709549,
-0.0010840861,
-0.0076367473,
0.0090711275,
-0.016668031,
0.0008549837,
0.0019805739,
0.017013345,
-0.0016742739,
0.018195381,
0.004313102,
-0.010073866,
-0.02442431,
0.009748474,
0.019324291,
0.0121059045,
0.015990686,
-0.0064945556,
-0.011667621,
-0.009987538,
0.014782087,
-0.0016086975,
-0.009462926,
0.0075703408,
-0.009648864,
-0.008300812,
0.007550419,
0.00040590973,
-0.004130484,
-0.0073910435,
0.022445396,
-0.0044392743,
-0.023627432,
-0.013307862,
-0.009157456,
0.01348716,
-0.0031825313,
0.056259584,
0.035593882,
0.011561371,
0.011116448,
-0.013115283,
0.029882925,
-0.0034099738,
-0.029245421,
-0.009376598,
0.015592245,
0.0024354584,
0.02207352,
0.011514887,
-0.022963367,
0.0063683833,
0.006959401,
-0.0011164593,
0.019961793,
-0.0032223754,
0.014954744,
0.0045023607,
-0.008413703,
-0.012969189,
-0.01850085,
-0.008307453,
0.009316832,
0.0057175993,
-0.003595912,
0.009735193,
-0.020506326,
-0.023414932,
-0.01777038,
0.011647699,
-0.008420344,
0.0037785298,
-0.014171147,
-0.014503179,
-0.015565683,
-0.023308681,
-0.0058504124,
0.0022428795,
-0.00037561177,
0.0048808777,
-0.021555549,
-0.008639486,
-0.04016265,
0.003861538,
-0.022671178,
0.026536036,
-0.046617363,
-0.022325864,
-0.0041636876,
0.019643042,
0.027651666,
0.015233651,
-0.019058665,
-0.00664397,
0.018819602,
-0.011189495,
-0.01031957,
-0.0034531378,
-0.041225154,
0.0054420126,
-0.0069062756,
0.007205105,
-0.026788382,
-0.004283219,
-0.013639895,
-0.009031284,
-0.012205514,
0.01389224,
0.0037851704,
-0.014875055,
0.010585196,
0.0051763863,
0.015339901,
0.019882105,
0.0056877164,
0.013945364,
-0.01072465,
-0.036417324,
-0.022126645,
-0.013679739,
0.013095361,
0.019377416,
0.00007263211,
-0.024411028,
-0.01603053,
-0.001869343,
0.007344559,
0.00275919,
0.0016161682,
0.017943036,
0.0070590107,
0.015844591,
-0.0065742433,
-0.0078094043,
-0.009363316,
-0.0061459215,
-0.0029003038,
0.033150125,
0.015406308,
-0.025845408,
0.015114119,
0.0006889674,
0.0010782755,
-0.020094607,
-0.0102199605,
-0.018341474,
0.03535482,
-0.0038947412,
0.0038349752,
-0.0018311592,
-0.006398266,
-0.014264116,
-0.001257573,
0.0066572516,
-0.0012069381,
-0.0110434005,
0.0037420061,
0.015658652,
-0.006826588,
-0.00018666452,
-0.029989175,
0.000572341,
0.013878958,
-0.011129729,
-0.014914899,
-0.015485995,
-0.0114551205,
-0.017026626,
-0.015260213,
-0.038993895,
-0.027651666,
0.004319743,
0.0024620208,
0.030467302,
0.038064204,
0.04159703,
0.0077629196,
0.017093033,
0.034770444,
0.0032439574,
-0.010844181,
-0.00480451,
0.011913326,
-0.021024298,
0.026084473,
0.017119596,
0.0040009916,
0.032246996,
-0.02022742,
0.012916064,
0.02871417,
-0.015804747,
-0.034398567,
0.011481684,
-0.015499277,
-0.03206106,
0.020586014,
-0.03819702,
0.010824259,
-0.04191578,
-0.0059301,
0.037878267,
0.016150061,
-0.0047414238,
0.005568185,
0.0124312965,
0.0026712015,
0.0103062885,
-0.0046252124,
-0.00011527753,
-0.026323536,
0.0024802827,
0.0067601814,
0.0037851704,
0.0078094043,
-0.011050042,
0.021396173,
-0.0029268665,
-0.011939889,
0.008227766,
0.012510984,
-0.025818847,
-0.008626204,
-0.008267609,
-0.02546025,
-0.019762574,
-0.008858627,
-0.017053189,
-0.05509083,
0.0019241283,
0.019895388,
-0.02595166,
0.020466482,
0.015100838,
0.0017498112,
0.05498458,
-0.0037552875,
0.020439921,
-0.014516461,
0.016003966,
0.019656323,
0.0020253982,
0.0006939479,
-0.02380009,
-0.011501606,
0.015485995,
0.0011762251,
0.031078242,
-0.02279071,
-0.017690692,
0.00960238,
-0.0022926843,
-0.014396929,
-0.023136023,
0.02298993,
-0.009848083,
0.014768805,
-0.005591427,
0.0017099674,
-0.020984454,
0.008798861,
0.0054121297,
0.005734201,
-0.0027940534,
-0.025154782,
-0.02013445,
0.01746491,
0.009841443,
0.0054220906,
0.013520363,
-0.036151696,
-0.008573079,
-0.009237144,
0.016973501,
0.009469567,
-0.02993605,
0.033468876,
0.028581357,
0.011355511,
0.011767232,
-0.0027857525,
-0.0077894824,
-0.011607856,
-0.00078235153,
0.036390763,
-0.00644143,
0.013314503,
-0.0022943446,
0.009376598,
-0.017039908,
0.0126902815,
-0.0035726696,
-0.020187575,
-0.040853277,
0.0053390823,
0.022551646,
0.019762574,
-0.033203248,
0.008851986,
-0.02433134,
0.0037088029,
-0.006570923,
-0.02494228,
0.009549255,
-0.042659536,
-0.01441021,
-0.014131303,
0.019058665,
0.014516461,
0.032857936,
-0.0071586207,
-0.0030580193,
0.035407946,
-0.0020718828,
0.009462926,
0.0019407299,
-0.0028488387,
-0.022777429,
0.03251262,
-0.014702398,
-0.03588607,
0.009662146,
-0.008672689,
-0.014330522,
-0.0007723906,
-0.0076500284,
0.028767295,
0.023162587,
-0.032459497,
0.015552402,
-0.0044392743,
0.02953761,
-0.0048576356,
0.0061160387,
0.0024138761,
-0.020439921,
0.015273495,
0.02442431,
-0.0029932729,
-0.013334425,
0.010213319,
-0.009535973,
0.0018344795,
-0.020506326,
-0.019961793,
-0.005375606,
0.008214484,
-0.0013223194,
0.01225864,
-0.007855888,
0.00013011524,
-0.016482092,
0.026854789,
0.009529333,
-0.008353937,
-0.026443068,
-0.0036357557,
-0.019576635,
0.007205105,
-0.031104803,
0.0009479528,
-0.00048144712,
-0.047679868,
-0.03466419,
0.01174731,
-0.043907978,
0.031928245,
-0.0051763863,
-0.030679801,
-0.03198137,
-0.021794613,
-0.04791893,
-0.003486341,
-0.0076101846,
0.01287622,
0.0014235893,
0.0066904547,
-0.012119186,
-0.015207089,
0.015990686,
0.0018643624,
0.004618572,
0.0061392807,
-0.016282873,
-0.0017747136,
0.0045222826,
-0.020918047,
-0.02411884,
-0.019430542,
0.029059485,
-0.02105086,
-0.009077769,
0.028767295,
-0.023547744,
0.009184019,
-0.015233651,
0.013513722,
-0.0004465837,
0.021409456,
0.047573615,
-0.030015737,
-0.010093788,
0.024238372,
0.011249261,
0.008739095,
-0.0028040144,
0.007344559,
-0.007019167,
-0.0010923869,
0.01114301,
-0.016468812,
0.0036224744,
0.011249261,
0.03115793,
0.028793858,
0.021196954,
0.011315667,
0.02349462,
0.0034531378,
-0.02697432,
-0.017199283,
-0.014569586,
-0.013055517,
0.010439102,
0.0014061576,
-0.016734438,
0.0019374096,
-0.008446907,
-0.019908668,
0.0033053835,
0.0132547375,
-0.026137598,
-0.032007933,
-0.0008607942,
-0.0034199348,
-0.011574653,
-0.0129293455,
0.002156551,
-0.016296154,
-0.017438347,
0.017956316,
-0.010943791,
-0.00079231255,
-0.024397748,
0.0066472907,
-0.0056877164,
0.0001174565,
-0.01205942,
-0.0036755996,
-0.008812143,
0.030095425,
0.17913817,
-0.02034695,
-0.015060994,
0.006614087,
0.0024802827,
-0.013785989,
0.006275414,
-0.003911343,
-0.00086411455,
-0.0007881621,
0.027306352,
0.014357085,
-0.0016510315,
-0.0027143657,
0.00888519,
-0.007942217,
-0.0055050985,
0.0073910435,
-0.0010043983,
-0.01460943,
0.0202407,
-0.00991449,
0.00022225425,
0.016668031,
0.014476617,
0.013274659,
-0.032671995,
0.01778366,
0.021900862,
-0.004445915,
-0.02033367,
0.014622711,
-0.012736767,
-0.0047746273,
-0.012730125,
0.016774282,
-0.014450054,
-0.007490653,
-0.014954744,
-0.0077961227,
-0.02268446,
0.008241046,
-0.016694594,
-0.0014858454,
0.008964878,
-0.028368857,
-0.0070590107,
-0.012577391,
-0.018646944,
0.028767295,
-0.040853277,
-0.005119941,
0.015446152,
0.024782905,
0.00056445523,
-0.00054702355,
0.015818028,
-0.00224952,
-0.014357085,
0.0069328384,
-0.0014667535,
0.00064829347,
-0.036443885,
0.01298247,
-0.02573916,
0.027067289,
0.005694357,
0.007696513,
0.023228994,
-0.022697741,
-0.018620383,
0.016070373,
0.00059184793,
0.0042334143,
0.018939134,
-0.03147668,
0.02708057,
0.012311765,
0.034186065,
0.026721975,
-0.0019125071,
0.004362907,
-0.018354757,
-0.0012310104,
-0.010903947,
-0.020572733,
0.022498522,
0.023255555,
-0.017557878,
-0.02402587,
0.005395528,
-0.023388369,
0.0005158955,
-0.006604126,
-0.009436363,
-0.000090945774,
-0.0027425883,
0.0037054827,
-0.0000031046984,
-0.023986027,
-0.031928245,
0.05599396,
0.012351609,
0.006985964,
-0.0038283346,
-0.017053189,
-0.0068929945,
0.019961793,
0.006607447,
-0.024185246,
0.0037918112,
-0.029298548,
0.0044392743,
-0.0077496385,
0.012384812,
0.00043454752,
0.000898978,
-0.014795368,
0.03463763,
-0.012391453,
0.0026944436,
-0.035381384,
0.009834803,
0.022219615,
-0.009150815,
0.013307862,
-0.027545415,
-0.005405489,
-0.016003966,
-0.028554793,
0.008732455,
-0.007337918,
-0.0054586143,
0.018328194,
-0.01665475,
-0.017225845,
0.017225845,
-0.0070058857,
-0.0028886828,
0.016309436,
-0.0070523703,
-0.0072715115,
0.011255901,
0.009489489,
-0.0200282,
-0.004751385,
0.017717253,
0.0070457296,
-0.005873655,
-0.0037021623,
-0.011063322,
-0.0028770615,
0.011056682,
-0.017451627,
0.034690756,
-0.024982125,
-0.0033452273,
-0.042978287,
0.01685397,
-0.0014684137,
-0.02749229,
0.014118021,
0.017664129,
-0.028262606,
-0.00012098434,
-0.00480119,
-0.16713187,
-0.002840538,
0.012995752,
-0.0147289615,
0.042792346,
0.0111098075,
0.01543287,
-0.009489489,
-0.012285202,
0.003036437,
0.016747719,
-0.008832064,
-0.04077359,
-0.020559452,
0.0027724714,
-0.015990686,
-0.03206106,
0.027545415,
0.001175395,
0.012039498,
0.009735193,
-0.0109570725,
0.026389942,
0.00074333773,
-0.018978978,
0.0026961039,
0.010472305,
-0.0108309,
-0.013141846,
-0.021595392,
-0.013234816,
0.010691446,
0.012683641,
0.005598068,
0.038967334,
0.01686725,
-0.0026828225,
-0.0021432696,
-0.01992195,
-0.007397684,
0.013168409,
0.009834803,
-0.004638494,
-0.009535973,
-0.011202776,
0.029643862,
0.012637157,
-0.00173653,
0.021329768,
0.0001273137,
0.022139927,
-0.017212564,
0.0045289234,
0.030228239,
0.03976421,
0.0136664575,
0.017518034,
0.002626377,
0.0020287186,
-0.0074574496,
-0.002931847,
-0.0032937622,
0.03065324,
-0.017199283,
-0.009974256,
-0.03277825,
-0.0072715115,
0.019696167,
-0.034797005,
0.0059931865,
-0.0030281364,
0.030175112,
0.016123498,
-0.018341474,
0.01624303,
0.01604381,
-0.016800843,
0.014529742,
0.010884025,
-0.0043761884,
-0.013706301,
0.03187512,
-0.030440738,
-0.026549319,
0.013971928,
0.0026147559,
0.0068797134,
0.0038914208,
-0.0062787347,
-0.0070523703,
0.0074640904,
-0.011999655,
-0.010107069,
0.010405898,
0.032034494,
0.008367219,
-0.009848083,
-0.021077422,
-0.00818128,
-0.018421162,
0.025978222,
-0.0018925852,
-0.030732928,
-0.003811733,
0.044625167,
0.016389124,
-0.00009307286,
0.017039908,
0.049512684,
-0.00664397,
-0.0059998273,
-0.005292598,
0.00079023733,
0.007995343,
-0.00899144,
0.035514195,
0.025619628,
0.0024869235,
-0.0066572516,
-0.018421162,
0.069965884,
0.015897715,
0.0032422973,
0.029271984,
-0.030493865,
-0.0011870161,
-0.11836294,
0.009775037,
-0.003748647,
0.0021930747,
-0.0065244385,
-0.003106164,
-0.0075836224,
0.018195381,
-0.008387141,
0.02259149,
-0.03588607,
-0.027757917,
0.0035029429,
-0.01215239,
0.0076566692,
-0.00500705,
0.034982942,
-0.0041437657,
-0.026111035,
0.032671995,
0.003024816,
0.016694594,
-0.0013040577,
-0.016827406,
0.013626614,
0.0034099738,
-0.030679801,
0.009263706,
-0.007517216,
0.01603053,
0.031131366,
-0.022299303,
0.026164161,
0.0066871345,
-0.016694594,
-0.006069554,
-0.006683814,
-0.039206397,
0.038276706,
0.00088984706,
-0.003321985,
0.0018842844,
0.0068398695,
-0.008254328,
0.0037918112,
-0.0101336315,
-0.021701643,
0.021741487,
0.028767295,
-0.02892667,
-0.023016492,
-0.017969599,
-0.034478255,
-0.026894633,
0.0055549038,
-0.019935232,
-0.0047347834,
0.031821992,
-0.00048767272,
0.008214484,
-0.0067601814,
-0.0051133004,
0.0015796446,
0.0089183925,
0.010638321,
0.0074176057,
-0.0029351672,
-0.024185246,
0.03692201,
-0.014210991,
-0.008646126,
-0.0017199283,
-0.017823504,
-0.020758672,
-0.016455531,
-0.01430396,
-0.022259459,
-0.022445396,
0.010492227,
-0.023003211,
-0.01226528,
-0.0056412322,
0.01399849,
-0.020200856,
0.026708694,
-0.006119359,
0.014224272,
-0.004993769,
0.013414113,
-0.0027973738,
0.003911343,
0.04712205,
-0.0026081153,
-0.026642287,
-0.016389124,
-0.0018427804,
0.010810978,
0.012750047,
-0.0043828287,
0.04281891,
-0.025513377,
-0.015193807,
-0.062475234,
0.0075637,
0.0070855734,
0.003698842,
0.012796532,
-0.02207352,
0.0067601814,
-0.004422673,
0.005598068,
0.0030796013,
-0.003977749,
0.003967788,
-0.011667621,
-0.012803173,
-0.005508419,
-0.007909014,
0.034876693,
0.006673853,
0.037054826,
0.022923524,
-0.02085164,
0.0020004958,
0.00960238,
0.014795368,
-0.010890665,
-0.008081671,
-0.023667276,
0.04651111,
-0.0068332287,
0.011607856,
0.0046650567,
-0.049831435,
-0.013400831,
-0.007909014,
-0.011076604,
-0.036204822,
-0.0049273623,
0.012032857,
0.021900862,
0.029325109,
-0.005531661,
-0.017889911,
0.012723485,
-0.011614497,
0.022963367,
-0.0062189684,
-0.00991449,
-0.014157865,
0.0014468316,
-0.032937624,
0.038356394,
-0.0035095834,
0.0049439636,
-0.03790483,
-0.030626677,
0.0028687608,
0.025566502,
-0.02034695,
0.006431469,
-0.013971928,
0.020878203,
0.035168882,
0.008971518,
-0.00080891413,
-0.0024337983,
-0.008699251,
-0.031928245,
-0.0047746273,
0.0005059345,
-0.04605955,
-0.01563209,
-0.0048908386,
0.021940706,
-0.0038482565,
0.023428213,
0.013639895,
-0.021422736,
0.0043496257,
-0.005528341,
0.031556368,
0.016216466,
-0.009575817,
0.0016775941,
0.019085228,
0.021011015,
-0.013241456,
-0.028740732,
0.002955089,
0.0032588989,
0.0025782322,
-0.008353937,
0.002410556,
0.0041968906,
-0.014171147,
0.012484422,
0.0046119313,
-0.0034664192,
0.017810224,
-0.0016941958,
0.044173602,
-0.002125008,
-0.015711777,
-0.0044027506,
-0.0056179897,
-0.024929,
0.039631397,
-0.030732928,
-0.041756406,
-0.019961793,
-0.003758608,
0.029165734,
0.01604381,
-0.011647699,
0.003937905,
-0.0052992385,
0.015273495,
0.010160195,
-0.001656012,
-0.014835211,
0.027943855,
0.010452383,
0.0075703408,
0.0041869297,
-0.019297728,
0.017597722,
0.013799271,
0.022737585,
-0.011534809,
0.01134223,
-0.03014855,
0.011388714,
0.0031410274,
-0.020413358,
-0.00095708366,
-0.025088375,
-0.025088375,
0.0029600696,
0.028953234,
-0.0102199605,
0.08675345,
0.0014958064,
-0.025632909,
0.0015148983,
-0.0113687925,
0.0063318596,
0.016681312,
0.012989111,
-0.01603053,
-0.02799698,
-0.0070523703,
-0.017504754,
0.00037561177,
-0.047972053,
0.0021515705,
0.03269856,
-0.0089183925,
0.013427394,
-0.016189905,
-0.01665475,
0.0075969035,
0.009768396,
-0.01287622,
0.030121988,
-0.029086046,
-0.001787995,
0.03413294,
0.022936804,
-0.0033352664,
-0.005169746,
0.0028488387,
-0.01103676,
-0.035115756,
0.0034697396,
0.012789892,
-0.011654341,
0.0034564582,
-0.033176687,
0.019563355,
0.03556732,
-0.0064845947,
-0.014556305,
-0.006222289,
-0.010100428,
0.020360233,
-0.009436363,
-0.005435372,
-0.017225845,
-0.008094952
] |
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neutrophils isolated from patients with various autoimmune diseases display enhanced neutrophil extracellular trap (NET) formation, a phenomenon that exposes autoantigens in the context of immunostimulatory molecules. We investigated whether aberrant NETosis occurs in RA, determined its triggers, and examined its deleterious inflammatory consequences. Enhanced NETosis was observed in circulating and RA synovial fluid neutrophils compared | [
-0.015475966,
-0.0048096483,
0.020288939,
-0.024344066,
-0.004683341,
0.024477022,
-0.009340092,
-0.0029316584,
-0.018613705,
-0.0062821256,
0.0041681402,
0.0004258716,
0.007525255,
0.00455371,
0.0068338886,
-0.002946616,
0.03510013,
0.0009730647,
-0.013202435,
-0.0005139543,
-0.038051732,
0.0105366865,
0.0075917323,
-0.0130761275,
0.014704827,
0.01386721,
0.012265102,
-0.04674699,
-0.015329716,
-0.0069269575,
0.007099799,
0.012178681,
-0.0109355515,
0.0042911237,
-0.004606892,
0.012304989,
0.023785656,
-0.010257481,
0.013302151,
0.016127445,
0.007039969,
0.004018566,
0.005165303,
0.012730445,
0.002654115,
0.00663778,
0.0031493723,
0.008768384,
-0.0074787205,
0.022469401,
0.029356472,
-0.0038955826,
-0.016978359,
-0.0038756393,
-0.012770331,
-0.018427568,
-0.01135436,
0.027840784,
0.0034834219,
-0.01930507,
0.00584005,
0.023280427,
-0.019890074,
-0.0016494734,
0.012557603,
-0.0031510342,
0.0057170666,
0.03879628,
-0.013488288,
0.009645888,
0.030526476,
0.023280427,
-0.0026458052,
-0.01901257,
0.005627322,
-0.013368629,
-0.0049027167,
-0.014771304,
-0.014412326,
0.008642077,
0.008422702,
-0.0075717894,
-0.0034701263,
0.0138406195,
0.010882369,
-0.009632592,
-0.00955282,
0.009745604,
0.01703154,
-0.004783057,
0.011646861,
0.012557603,
0.027388737,
0.0042246464,
-0.008083666,
0.022522584,
0.0011625256,
0.0058799363,
-0.004746495,
-0.032121938,
-0.009320148,
0.002868505,
-0.013641187,
-0.020382008,
-0.008136848,
0.011866237,
0.0042645326,
-0.00018135898,
-0.0016428257,
-0.0038457243,
-0.0046168636,
0.013355333,
0.0057669245,
-0.043742206,
0.021897694,
-0.011646861,
0.028372604,
0.005989624,
-0.0017300774,
-0.014837782,
0.0082432125,
0.034036487,
0.01688529,
0.00032594756,
0.021458942,
0.0024330772,
-0.020169279,
0.0003255321,
-0.01717779,
-0.013760846,
-0.01992996,
0.0159679,
0.025381116,
0.0012663967,
-0.00072169653,
0.013508231,
-0.03172307,
-0.016898585,
-0.021884399,
-0.02113985,
0.0060128914,
0.023519745,
-0.02333361,
-0.016845403,
0.02179133,
0.027362145,
0.027681239,
0.020953713,
0.017324042,
-0.0040052705,
-0.0073191747,
-0.02616555,
0.002600933,
-0.021419056,
-0.01797552,
0.0053979745,
-0.0010337254,
0.036004223,
-0.046135396,
-0.011746577,
0.0057436577,
-0.00073416106,
0.014199598,
-0.014199598,
-0.007817756,
0.016805517,
-0.0015713624,
0.009233727,
-0.0023466563,
-0.016340174,
-0.010955495,
-0.008868101,
-0.013973574,
-0.003672883,
0.0012688896,
0.014173007,
-0.0019644105,
-0.0024746256,
-0.025620434,
-0.026817031,
0.0074853683,
0.020142687,
0.026750553,
-0.025474185,
0.016965063,
-0.005165303,
0.043343343,
-0.019344958,
-0.0061890567,
0.0017417109,
-0.0094663985,
0.017550064,
-0.015343011,
-0.04039174,
-0.6390351,
-0.010177708,
0.047225628,
-0.002944954,
0.02060803,
0.018228136,
0.008163439,
-0.0063087163,
-0.022123719,
0.016606083,
-0.025354525,
0.012364818,
0.01717779,
-0.004842887,
0.0015082087,
-0.031616706,
-0.010463561,
-0.01306948,
0.03560536,
0.006322012,
-0.0050389958,
-0.009998218,
-0.0098652635,
-0.004251237,
0.0064616147,
-0.006139199,
-0.004041833,
-0.018254727,
-0.003932145,
0.03228148,
-0.02773442,
0.0015015609,
-0.0070266738,
-0.008741793,
0.0544052,
-0.0060693976,
-0.0035498994,
0.028718287,
0.011427485,
0.019225297,
0.0007395624,
-0.013042889,
0.004766438,
-0.010131174,
-0.0075319028,
0.010948847,
-0.009486342,
0.0118529415,
0.0068139457,
-0.008110257,
0.0002542765,
0.009871911,
-0.011892828,
0.0028286183,
0.02980852,
0.0022535878,
-0.0034601549,
-0.0162604,
-0.0083362805,
0.0097589,
0.0006793171,
0.0021006896,
-0.01969064,
-0.0343024,
-0.020169279,
0.00925367,
-0.015515853,
0.006631132,
-0.0028618572,
0.00219542,
0.0051819226,
0.021193033,
-0.016286992,
0.014319257,
0.024596682,
0.03900901,
-0.018533932,
0.0065380638,
-0.0343024,
-0.017071426,
-0.007917472,
0.0013220717,
-0.0150638055,
0.0058566695,
0.02667078,
0.011786464,
-0.028851243,
0.017882451,
0.008003893,
-0.026032595,
-0.0123116365,
0.019291775,
-0.03669559,
-0.026391575,
-0.023719179,
0.020023027,
-0.011540497,
0.0014857725,
0.0009182207,
0.003317228,
-0.01096879,
0.0026175522,
0.0033271997,
-0.009532876,
0.024357362,
0.014013461,
-0.02877147,
-0.004626835,
0.04174788,
-0.029941473,
-0.0076715057,
0.0041216062,
-0.011872885,
-0.03616377,
0.003134415,
-0.014226189,
-0.002516174,
0.02587305,
-0.0064682625,
-0.02901079,
0.0046966365,
0.0077911653,
0.009094125,
-0.010117878,
-0.01333539,
0.0110884495,
0.00088830583,
-0.03563195,
-0.0140533475,
-0.03512672,
-0.009134011,
-0.005098826,
0.0042711804,
-0.0045470623,
0.034036487,
0.0145452805,
0.014877669,
-0.004131578,
-0.0064749103,
-0.040232193,
-0.021153146,
-0.006631132,
0.0074654254,
-0.010277424,
-0.006933605,
-0.0071928673,
0.0030214032,
-0.010470209,
0.00792412,
0.03834423,
0.018720068,
0.007631619,
-0.018228136,
0.009672479,
0.007970654,
-0.000615748,
-0.015037214,
-0.028984198,
-0.0070732078,
-0.022761902,
-0.0022685453,
-0.0061524943,
0.00498249,
0.005836726,
-0.007811108,
-0.0048595066,
0.0064350236,
0.006504825,
0.0032224976,
-0.014917555,
-0.00530823,
-0.021445647,
-0.015023919,
0.013248969,
-0.0066876383,
0.03166989,
-0.018148363,
-0.021857807,
0.01608756,
-0.002356628,
0.006238915,
-0.010835836,
0.008216621,
-0.011693396,
0.03148375,
0.0028468997,
0.028053513,
0.013022945,
-0.004181436,
0.042917885,
-0.038158096,
0.006528092,
-0.04118947,
0.0171512,
0.0022835028,
-0.03063284,
0.0028053513,
0.026418166,
0.02466316,
0.026271915,
-0.021392465,
0.0034668024,
0.03432899,
-0.0019045809,
0.011128336,
0.0031959068,
-0.005095502,
-0.024862591,
0.02708294,
-0.014013461,
-0.020435188,
0.010031457,
0.0008463419,
0.0020973657,
-0.014305961,
0.014890964,
0.004424079,
0.004849535,
0.003295623,
-0.016207218,
-0.0027521693,
0.0064749103,
0.012963116,
-0.010490152,
-0.008874749,
0.009001056,
0.025434298,
0.020328825,
0.005115445,
-0.016871994,
-0.013747551,
0.012550956,
0.014771304,
0.019650754,
0.0067341723,
0.014119824,
-0.009346739,
0.008934578,
0.017098017,
0.0057203905,
-0.002303446,
-0.002763803,
-0.014571872,
0.010609812,
0.011015325,
-0.008369519,
0.012025783,
0.022296559,
0.0040817196,
0.015662104,
-0.0060893404,
0.023878723,
-0.033584442,
0.018560523,
-0.01135436,
0.008449293,
-0.0036762068,
0.007518607,
0.051347233,
0.013202435,
0.040551286,
-0.0147580085,
-0.00567718,
-0.022269968,
0.0147846,
-0.0010777668,
0.022549175,
-0.022363037,
0.02048837,
0.003692826,
-0.028026922,
-0.008322985,
0.001283847,
-0.03536604,
0.004570329,
0.010629755,
0.012830161,
0.03299944,
0.016100856,
0.016393356,
-0.016007787,
-0.03379717,
0.016845403,
0.017137904,
-0.007684801,
-0.010955495,
-0.015382897,
-0.010523391,
-0.006780707,
0.025859755,
0.02297463,
0.013720959,
0.010736119,
0.016340174,
-0.006139199,
0.0023134176,
0.033238757,
-0.030473294,
0.013328742,
-0.009732309,
0.010882369,
-0.024503613,
-0.0058566695,
-0.0026391575,
0.023400087,
0.0028635191,
-0.0047331993,
-0.011002029,
-0.011813055,
-0.041907426,
0.0104768565,
-0.011640213,
0.0037593036,
0.008834862,
-0.018440863,
-0.008156791,
0.0151568735,
-0.009499637,
0.018174954,
-0.0074720727,
-0.013760846,
-0.034701265,
0.0046135397,
-0.0033604384,
0.025593843,
0.019145524,
-0.008628782,
0.030712614,
-0.0049126884,
0.007339118,
0.012916582,
-0.04305084,
0.030792385,
-0.0027205923,
-0.012457887,
-0.0043708966,
0.030872159,
0.011274587,
0.021964172,
0.04039174,
0.022682128,
-0.024317475,
0.0062954207,
0.013428459,
0.0072460496,
-0.013162549,
0.012644024,
0.0260193,
0.030659432,
-0.020475075,
0.009306853,
0.0024280914,
0.023639405,
-0.030340338,
-0.0005143698,
0.011992544,
-0.0064749103,
-0.011061859,
-0.0066809906,
-0.027867375,
0.009692422,
0.032095347,
0.015888127,
0.0029665593,
-0.00048528588,
0.0022918123,
0.015502557,
-0.0070732078,
-0.010084639,
0.0054744235,
0.03512672,
0.012039078,
0.0048661544,
-0.03408967,
0.014598463,
-0.014186302,
0.0077978126,
-0.005953062,
0.016592788,
-0.0059563858,
0.019823596,
-0.008462588,
-0.009918446,
-0.016340174,
-0.005620674,
0.011234701,
0.0016627689,
-0.011347712,
-0.021844512,
-0.027920557,
-0.01061646,
-0.009153954,
-0.02125951,
-0.0023416704,
-0.012019135,
-0.031111479,
-0.013574709,
0.01910564,
0.010490152,
0.016699152,
0.024370657,
0.011241348,
0.0033803817,
0.036801953,
-0.011859589,
0.0010121202,
0.009114068,
-0.03536604,
0.024078157,
0.012092261,
0.011420838,
-0.022363037,
-0.007857642,
0.022150308,
0.012517717,
-0.021099964,
0.038663324,
0.02261565,
0.0027355498,
-0.009931741,
0.0018547227,
0.010942199,
-0.009439807,
-0.009632592,
-0.020834055,
-0.040498104,
-0.0145452805,
-0.01957098,
-0.013720959,
-0.019863483,
-0.007744631,
-0.013042889,
0.0020408598,
-0.019079048,
0.00391885,
-0.0019926636,
-0.025394412,
-0.020514961,
-0.00706656,
0.022230081,
-0.021831216,
0.009346739,
0.0036130531,
0.0061458466,
0.001203243,
-0.0056904755,
0.011228053,
-0.008296394,
0.004131578,
0.014013461,
-0.013116014,
-0.023519745,
-0.016858699,
-0.01739052,
-0.01490426,
0.035312857,
0.0060461303,
-0.02123292,
-0.037121046,
-0.0073657087,
-0.013202435,
0.008741793,
0.001631192,
-0.024809409,
-0.0051486837,
-0.0030878808,
-0.013295503,
0.007093151,
0.026630893,
-0.030739203,
0.0007416398,
0.012145442,
-0.037147637,
-0.0056572366,
-0.013195788,
0.0011741591,
-0.017603246,
-0.0022585737,
-0.03326535,
-0.007172924,
0.0075319028,
-0.013720959,
0.04964541,
0.01505051,
0.028478969,
-0.017603246,
0.023439972,
0.026617598,
0.010855778,
0.016845403,
-0.016419947,
0.021219624,
-0.01386721,
0.028665105,
0.010377141,
-0.0057702484,
0.016340174,
-0.029383063,
-0.0051785987,
0.0107826535,
-0.007093151,
-0.02930329,
-0.0037061216,
-0.045311075,
0.0058666407,
0.031005114,
-0.003347143,
0.02179133,
-0.038902644,
0.016100856,
0.023599518,
0.025101911,
0.0078443475,
-0.008170087,
0.033185575,
-0.013581357,
0.017603246,
-0.03230807,
0.009054238,
0.004706608,
0.0060328348,
0.0049160123,
0.007950711,
0.01939814,
0.0010844145,
0.008788328,
0.008442645,
0.0024480345,
-0.011407542,
-0.01339522,
-0.017204382,
-0.03940787,
-0.032893077,
-0.009825377,
0.006704258,
0.00070341525,
-0.013960279,
-0.035206493,
0.019677345,
-0.003749332,
-0.0012256792,
0.012238511,
-0.021924285,
-0.016606083,
0.031217841,
-0.0123116365,
0.005650589,
-0.03480763,
-0.005966357,
0.01942473,
0.0029499398,
-0.022017354,
0.009499637,
-0.012856752,
0.0025959471,
0.028904425,
0.026178846,
-0.015130283,
-0.012830161,
-0.0027770982,
0.0068405364,
-0.022456106,
-0.036057405,
0.045842897,
0.003212526,
0.025793277,
-0.014691532,
-0.02776101,
-0.003925497,
0.004071748,
-0.019491209,
-0.003106162,
0.0017583304,
0.00492266,
-0.03355785,
0.009685774,
-0.029117152,
0.04568335,
-0.017244268,
-0.020249052,
-0.009652535,
-0.015928013,
0.016247105,
0.00863543,
0.008349576,
0.027109532,
0.007970654,
0.017124608,
0.008768384,
0.0155823305,
0.0025743418,
-0.012790274,
-0.002278517,
0.042864703,
-0.0024463725,
-0.006398461,
0.023094289,
0.013096071,
-0.00049650396,
-0.012963116,
-0.00019912094,
0.000989684,
-0.028585333,
-0.0025377793,
0.023985088,
0.009719013,
-0.03597763,
0.008183382,
-0.019797005,
0.00176664,
-0.012943173,
0.0043675727,
0.010004866,
-0.03980674,
-0.03613718,
0.014438917,
-0.0069003664,
0.012491126,
-0.0036595874,
0.00804378,
-0.017071426,
0.0026158902,
-0.026910098,
0.013375277,
0.0028801383,
0.00937333,
0.0096192965,
0.0013569723,
-0.020355416,
-0.0038124856,
0.031510342,
0.0017084721,
-0.028106695,
-0.0090077035,
0.0061724377,
0.011520553,
0.020754281,
-0.014345848,
0.04932632,
0.00045952585,
0.00067848613,
0.012424648,
0.019916665,
0.021073373,
0.0018098505,
0.016632674,
0.031856027,
0.0033587764,
-0.00020514546,
0.020036323,
0.010330606,
0.017164495,
-0.0064350236,
-0.02362611,
-0.023439972,
0.017576655,
-0.015449375,
-0.030579658,
0.020541552,
0.011420838,
-0.014970737,
0.0033371714,
0.027255783,
-0.01082254,
0.0054245656,
0.0056140264,
-0.015874831,
-0.001311269,
0.0038457243,
-0.003051318,
0.010696232,
-0.0039786794,
-0.008103609,
0.013614596,
-0.022456106,
0.03196239,
0.01584824,
-0.027229192,
-0.009978276,
-0.0010536687,
-0.037094455,
-0.0006585429,
-0.03249421,
-0.01756336,
0.017111313,
-0.004181436,
0.014625054,
-0.00094813557,
-0.012677263,
-0.0045038518,
-0.018720068,
-0.011832998,
-0.006554683,
-0.020501666,
0.015542444,
0.0042944476,
-0.03036693,
-0.0026640864,
0.02770783,
-0.017044835,
-0.004317715,
0.014279371,
0.0147580085,
-0.009393273,
-0.015981195,
0.009599353,
-0.01572858,
0.0019644105,
0.015542444,
-0.03249421,
0.0021505477,
0.024796113,
0.0023067698,
-0.025966119,
0.012358171,
0.030021247,
0.012418,
-0.021831216,
-0.016871994,
-0.027920557,
0.0029133772,
-0.0036595874,
0.030021247,
0.044327207,
-0.026763849,
0.011660157,
-0.0064948536,
-0.009572762,
-0.015954604,
-0.009991571,
0.01188618,
-0.005195218,
0.00013087761,
-0.004061776,
-0.0015547429,
0.0061990283,
0.027867375,
-0.029196925,
-0.004231294,
-0.0058799363,
0.01886632,
-0.031217841,
-0.012776979,
-0.0008725174,
0.010443618,
0.025088616,
-0.021658376,
-0.027388737,
0.0008023005,
-0.013800733,
-0.005168627,
-0.021472238,
-0.018853024,
0.0023150796,
-0.008023837,
-0.008628782,
-0.0077778697,
-0.028744878,
-0.023426678,
0.022110423,
0.17645793,
-0.014824486,
-0.0051220926,
0.0004628497,
-0.0319358,
-0.0120656695,
-0.002943292,
-0.014492099,
-0.008755089,
0.014678236,
0.04669381,
0.017536769,
-0.015037214,
0.0034734502,
-0.016366765,
-0.012757036,
-0.024982251,
0.008342928,
-0.013195788,
-0.023253836,
0.018786546,
0.006531416,
0.030659432,
0.020834055,
0.03914196,
-0.009326796,
0.005384679,
-0.013494936,
0.0165529,
-0.003320552,
-0.035525586,
0.008502474,
-0.00071130943,
-0.00093567104,
-0.0035565472,
0.007930768,
-0.0060128914,
0.01747029,
0.008269804,
0.020209165,
0.011247996,
-0.004769762,
0.006953548,
-0.005461128,
-0.014266076,
0.0024812734,
-0.0015597288,
-0.044726074,
-0.003426916,
0.016725743,
-0.04065765,
-0.013388572,
0.007119742,
-0.017629838,
0.023665996,
-0.013893801,
0.013162549,
0.020528257,
-0.010091287,
0.023187358,
0.00014895119,
0.019118935,
-0.053022467,
0.038158096,
-0.02084735,
0.005088854,
0.00305298,
-0.0004190161,
0.009459751,
-0.015529148,
0.020275643,
-0.015595625,
-0.0051520076,
-0.0023798952,
-0.0125243645,
-0.015821649,
0.010948847,
0.010124526,
0.012770331,
0.011015325,
0.026657484,
0.033158984,
-0.038264457,
0.0056904755,
-0.019464618,
-0.042678565,
-0.0013943659,
0.012172033,
-0.024503613,
-0.020009732,
-0.0006107622,
-0.023812247,
-0.022522584,
-0.0073657087,
0.028186467,
-0.002652453,
0.017789384,
-0.012278398,
-0.014851077,
0.027548283,
-0.022110423,
0.09264307,
-0.0031842731,
0.023386791,
-0.030127611,
0.006803974,
-0.0022203492,
0.012663967,
0.015888127,
0.0026142283,
0.0032607222,
-0.020182574,
-0.0046135397,
-0.01188618,
-0.0036861782,
0.0209936,
-0.004570329,
-0.010563278,
0.025553958,
-0.0037094455,
0.00025157587,
-0.023971792,
0.005524282,
0.014119824,
-0.00786429,
0.016712448,
-0.008681964,
0.0067840307,
-0.0048694783,
-0.02546089,
-0.0028718289,
-0.0017300774,
-0.0038224573,
-0.007418891,
-0.0139336875,
0.0066078654,
0.0011093436,
-0.025407707,
0.018108476,
0.008329633,
-0.02090053,
-0.008715202,
0.02930329,
0.003510013,
-0.0015838268,
0.010623108,
0.008801623,
0.0015946295,
-0.029702155,
0.009765548,
0.0017300774,
0.0034335637,
-0.0013428458,
-0.014093233,
0.006169114,
-0.030765794,
-0.02507532,
-0.0070067304,
-0.010343902,
0.00984532,
-0.042066973,
-0.001553912,
0.017882451,
-0.0135946525,
0.0016012772,
-0.0141464155,
-0.1667788,
0.014319257,
0.0129232295,
-0.023134176,
0.024118043,
0.027282374,
0.016685857,
0.010024809,
-0.021432351,
-0.0072526974,
0.057862032,
0.0057669245,
-0.017137904,
-0.021924285,
0.0036795307,
0.0046201875,
-0.0021555335,
0.03432899,
0.026564416,
0.008974465,
0.028691696,
-0.050416548,
0.025168387,
-0.027441919,
-0.0072925836,
0.032919668,
0.017204382,
-0.004786381,
-0.0052916105,
-0.011713339,
0.0027388737,
-0.0036064053,
0.036509454,
0.011221405,
0.0020707746,
0.016300287,
-0.010682937,
0.003244103,
-0.012391409,
0.016300287,
0.035525586,
-0.0021788005,
0.006704258,
0.009679127,
-0.014359144,
0.044779256,
0.0062788017,
0.0022685453,
0.02770783,
-0.012863399,
-0.00013908344,
-0.011899476,
0.015183465,
0.0021538716,
-0.005733686,
0.02285497,
0.0065413876,
0.013288856,
0.0095262285,
-0.014226189,
0.0051852465,
-0.023985088,
0.052597012,
0.0057203905,
0.0075717894,
-0.019876778,
0.00015134022,
0.023280427,
-0.00035295406,
0.0005052291,
-0.011261292,
0.0021638433,
-0.0040850434,
-0.030047838,
0.020302234,
0.014199598,
-0.027335554,
0.016539607,
0.007764574,
0.0028585333,
-0.01398687,
0.00786429,
-0.017815975,
-0.018640297,
-0.0011450752,
-0.0070000826,
0.005431213,
0.019797005,
0.0019461294,
-0.011919419,
-0.0015347997,
-0.045257892,
0.005105473,
-0.009792138,
0.0019378196,
0.023985088,
-0.008681964,
0.018135067,
-0.021445647,
-0.013946983,
0.0051885704,
-0.027654648,
-0.014944145,
0.011507258,
0.009280262,
0.0026059188,
0.010144469,
-0.010490152,
0.02797374,
-0.030207384,
-0.0036529396,
0.0108424835,
0.0012182005,
0.03169648,
-0.021365874,
0.021219624,
0.029675564,
-0.0015979534,
0.008615486,
-0.048927452,
0.07376345,
0.01386721,
-0.0044839084,
0.020062914,
-0.015941309,
-0.033983305,
-0.13029593,
-0.024649864,
-0.00039408702,
0.0017483587,
-0.031829435,
0.002303446,
-0.008974465,
0.030978523,
-0.033664215,
0.01274374,
-0.010523391,
0.010463561,
0.014997328,
-0.009858616,
0.011965953,
0.008801623,
0.0034900696,
-0.019238593,
-0.02548748,
0.022296559,
0.011593679,
0.004201379,
0.010855778,
-0.00085755996,
-0.0077978126,
-0.0072593447,
-0.0119460095,
0.020940417,
-0.00898776,
-0.00020431449,
-0.0089146355,
0.0089146355,
0.013116014,
-0.020661213,
0.0000021748017,
-0.014837782,
-0.0064117564,
-0.016592788,
0.027654648,
-0.016313583,
-0.008389463,
0.006853832,
0.018853024,
-0.008542361,
-0.00076116755,
-0.0120058395,
-0.010676289,
-0.0113942465,
0.015595625,
-0.013641187,
-0.00023931907,
-0.0078044604,
-0.03491399,
-0.010490152,
0.02164508,
0.0083961105,
-0.0039687078,
0.0393281,
-0.011214757,
-0.011341064,
-0.00056630536,
-0.010343902,
-0.00076739985,
0.012032431,
0.02879806,
-0.008788328,
0.0053447923,
-0.009140658,
0.0049060406,
-0.005673856,
0.013973574,
-0.02696328,
-0.008296394,
-0.009087477,
-0.01120811,
0.010257481,
-0.030712614,
-0.008269804,
0.013694368,
-0.012138795,
-0.024064861,
-0.012098908,
0.013375277,
-0.0062588584,
0.02466316,
0.01635347,
0.020355416,
0.0042213225,
-0.011626918,
-0.0103239585,
-0.0059032035,
0.03353126,
0.0087949755,
0.00018603318,
-0.005311554,
0.015941309,
-0.015303125,
-0.028213058,
0.015236647,
0.014106529,
-0.016207218,
-0.01768302,
-0.04807654,
0.007857642,
-0.0025793277,
-0.009034295,
0.0062954207,
-0.023852134,
0.018839728,
-0.030872159,
0.0052384282,
0.020009732,
-0.035073537,
0.025035433,
0.0048295916,
0.009499637,
-0.010423675,
-0.0018281317,
0.03143057,
0.010776006,
0.029728746,
0.0026989873,
-0.012657319,
0.0050722347,
0.0022535878,
0.025022138,
0.013800733,
-0.0052351044,
-0.028585333,
0.0031460484,
0.0076183234,
-0.0018248078,
0.0076515623,
-0.04302425,
-0.0029781929,
-0.004816296,
-0.026896803,
-0.021086669,
-0.023892019,
0.026630893,
-0.0104968,
0.03249421,
-0.021060077,
-0.03539263,
0.022894857,
-0.0034102967,
-0.012145442,
-0.016313583,
-0.03270694,
0.008435997,
-0.0021871103,
-0.01780268,
0.024995547,
0.0083362805,
-0.0047298754,
-0.044726074,
-0.035791494,
0.01886632,
0.0024181197,
-0.013893801,
-0.015741875,
-0.019544391,
0.027335554,
0.015010623,
0.018613705,
0.018799841,
-0.0074321865,
0.017736202,
-0.023160767,
0.008489179,
0.00674082,
-0.0036462918,
-0.025740094,
0.0012713826,
-0.0031045,
0.018400976,
0.035871267,
0.0030114315,
-0.016672561,
0.0031460484,
0.00477641,
0.0005251724,
0.0089478735,
-0.0040584523,
-0.019876778,
0.0050090807,
0.03454172,
-0.006099312,
-0.009825377,
0.0110884495,
-0.017510178,
0.0063918135,
-0.013667777,
0.017111313,
0.0063552507,
0.008489179,
-0.015489262,
0.014704827,
0.004497204,
0.012717149,
0.014066643,
0.044752665,
0.007492016,
0.0053614117,
-0.00018935706,
-0.034435354,
0.0005284963,
0.010284072,
-0.042306293,
-0.024649864,
-0.0155823305,
-0.0023283751,
0.017284155,
-0.00028336042,
-0.011008677,
-0.00048528588,
-0.0066876383,
0.020368712,
-0.009300205,
-0.004812972,
-0.0031626679,
-0.004812972,
0.024676455,
0.01785586,
-0.020395303,
-0.008382815,
0.00016411637,
0.006803974,
0.022549175,
-0.016446538,
0.02374577,
-0.0007524424,
0.024064861,
-0.022775197,
-0.03698809,
0.0105366865,
-0.03143057,
-0.020182574,
0.034169443,
0.02901079,
-0.036323316,
0.08083666,
0.019544391,
-0.0037858947,
0.02102019,
-0.00251285,
0.002115647,
0.014425621,
0.0057602767,
0.013308799,
-0.022668833,
0.024091452,
0.005281639,
0.040046055,
-0.027628057,
-0.0201028,
0.015808353,
-0.0067275246,
0.005969681,
0.0015929675,
-0.00978549,
0.0162604,
0.015037214,
-0.0075385505,
0.008382815,
-0.01638006,
0.018494045,
0.016207218,
-0.01664597,
-0.0018264698,
-0.024251,
-0.02244281,
-0.009200488,
-0.055787932,
0.00027006492,
0.015303125,
-0.01638006,
-0.012145442,
-0.03757309,
0.0072460496,
-0.013342038,
-0.009659183,
0.042731747,
-0.015941309,
-0.021179738,
0.0011832998,
-0.005201866,
-0.012491126,
-0.010317311,
-0.0150638055
] |
The emergence of immuno-oncology as the first broadly successful strategy for metastatic cancer will require clinicians to integrate this new pillar of medicine with chemotherapy, radiation, and targeted small-molecule compounds. Of equal importance is gaining an understanding of the limitations and toxicities of immunotherapy. Immunotherapy was initially perceived to be a relatively less toxic approach to cancer treatment than other available therapies—and surely it is, when compared to those. However, as the use of immunotherapy becomes more common, especially as first- and second-line treatments, immunotoxicity and autoimmunity are emerging as the Achilles' heel of immunotherapy. In this Perspective | [
-0.008710338,
-0.010653913,
-0.002990116,
-0.026677035,
0.00087022124,
0.017888693,
-0.022867886,
-0.01982577,
-0.011141432,
-0.006805764,
0.02627402,
-0.0023579665,
0.0030031165,
0.00013183324,
-0.008209818,
-0.0023839674,
0.05075397,
-0.010920423,
-0.008911845,
0.00257735,
-0.04154961,
0.0071567777,
-0.0013683031,
0.010738417,
0.008034311,
0.012551987,
0.009568371,
-0.061102368,
-0.011290938,
-0.009353863,
0.0063572465,
0.0010879796,
-0.011349441,
-0.0005196139,
-0.027457064,
-0.008931346,
0.023673918,
-0.011661452,
0.008554332,
-0.001961451,
-0.002658603,
-0.003818898,
-0.0009409115,
-0.010010389,
-0.014677569,
0.011017927,
0.01107643,
-0.023907928,
-0.019552758,
0.01469057,
0.015366596,
0.0058664777,
-0.015275592,
-0.0078068026,
-0.0019955775,
-0.013845537,
-0.012662491,
0.032449257,
0.027795078,
0.00035060736,
-0.019838769,
0.00013955228,
-0.006464501,
0.028653111,
-0.0073647858,
0.008723338,
-0.013975542,
0.008196818,
-0.009704877,
-0.0024668456,
0.027197056,
0.032839272,
-0.016978659,
0.016172627,
0.016809652,
-0.027717074,
-0.018434715,
0.0017420675,
0.009717877,
0.0024570953,
-0.0042479145,
-0.00954887,
-0.0015600605,
0.014495562,
0.02191885,
0.017719688,
0.016874654,
0.001600687,
0.02706705,
-0.0038969012,
0.022737881,
0.0077743013,
0.013533525,
0.011472945,
-0.009678875,
0.019136742,
0.0045599267,
0.020943813,
0.0005253016,
-0.035413373,
0.0028471104,
0.006987771,
-0.016393635,
-0.018655723,
-0.024024932,
0.0132995155,
0.0006926831,
0.012486984,
0.018720726,
0.0057234718,
-0.00085234555,
0.040067554,
-0.016198628,
-0.026209017,
0.02787308,
0.0023855926,
0.033385295,
0.0153795965,
-0.01982577,
-0.01341652,
-0.005648719,
0.007839304,
0.010140393,
-0.021970851,
0.027613072,
-0.022217862,
-0.03684343,
-0.012590989,
-0.00066465075,
0.005515464,
0.00619474,
0.015405597,
0.0044819238,
-0.0008295947,
0.004234914,
0.009152355,
-0.015015583,
-0.010088392,
-0.009243359,
-0.016328633,
-0.0005955856,
0.025597993,
0.004618429,
0.001597437,
-0.015288593,
0.013507524,
0.029303137,
0.014144548,
0.001148107,
0.000735341,
-0.020176783,
-0.027691074,
-0.010679915,
-0.012909501,
-0.011726455,
-0.0010432905,
0.0039619035,
0.018655723,
-0.0068707666,
0.010692915,
0.0049499418,
-0.016809652,
0.0075142914,
0.008196818,
0.015639607,
0.018408714,
0.027639072,
0.015340595,
-0.014391558,
-0.0027999836,
-0.0031591225,
0.028757116,
-0.004722433,
0.027379062,
-0.035361372,
0.010907423,
-0.00054602115,
0.035985395,
-0.03042118,
-0.018226707,
0.0132410135,
0.0007438726,
0.00929536,
-0.0089833485,
-0.024037933,
0.010803419,
0.00953587,
-0.0044071707,
0.0065100025,
-0.023101896,
0.012850998,
0.036219403,
0.006402748,
-0.011199934,
-0.6344246,
-0.026755037,
0.011693954,
-0.022308866,
0.0056259683,
0.014001543,
0.027431063,
-0.014547564,
-0.008931346,
0.016926656,
-0.01628963,
0.028289096,
0.010920423,
-0.039599534,
-0.0022734632,
-0.026404023,
-0.009321362,
-0.034685344,
0.0008003435,
-0.0154185975,
0.016315633,
0.011505446,
-0.016510641,
-0.0056617195,
-0.0074232877,
-0.013962542,
0.012909501,
-0.015639607,
0.0008564082,
0.038793504,
-0.033021282,
0.01058891,
-0.0005484588,
-0.020735804,
0.046775814,
0.0031331214,
0.009262859,
0.013091507,
0.0095943725,
0.029329138,
-0.008183817,
-0.013163011,
0.024817962,
-0.010959425,
-0.020969814,
0.02117782,
0.027509067,
-0.012766495,
0.008281321,
-0.007852305,
0.014625567,
0.016328633,
-0.026586032,
0.0044266717,
0.016393635,
0.009321362,
0.020930812,
-0.021554835,
0.010803419,
-0.021320827,
0.0027284808,
-0.0048654387,
-0.016120626,
-0.032345254,
-0.011368941,
0.022802884,
-0.027561069,
0.000074803684,
0.006727761,
0.008885845,
0.0150935855,
0.033905316,
-0.0036433912,
-0.019643761,
0.026534028,
0.029953161,
5.348108e-7,
-0.006633507,
0.0086778365,
0.012090469,
0.012239975,
-0.010270398,
-0.031877235,
0.0206188,
0.025754,
-0.02347891,
-0.008222819,
-0.00015295905,
0.018512718,
-0.0041959127,
0.012733994,
0.0030096166,
-0.0024310942,
-0.040613577,
0.0037116439,
0.009308361,
0.011674453,
0.022204861,
0.013455522,
-0.02089181,
-0.025077973,
-0.020696802,
-0.0007048711,
0.0038351486,
-0.00489144,
-0.011778457,
-0.019435754,
-0.0020427043,
0.048621885,
-0.00954887,
0.007527292,
0.0035946395,
0.0036531417,
-0.00024944718,
0.020956812,
-0.008463328,
0.0064612506,
0.020722803,
-0.0037083938,
-0.010939924,
0.026131013,
-0.006243492,
0.006061485,
0.0056357183,
0.0059672315,
-0.007462289,
-0.00079709344,
-0.012473984,
-0.003994405,
-0.017342672,
0.0003910308,
-0.044747736,
-0.0010644163,
-0.011680953,
0.016380636,
0.00025350982,
0.0059737316,
-0.0042186636,
-0.014573565,
-0.007871806,
-0.00062808685,
-0.016120626,
0.00670176,
0.025324982,
-0.01833071,
-0.017927695,
-0.026027009,
-0.008866344,
-0.00037112378,
0.012512986,
0.012194473,
0.007455789,
0.0023287153,
0.030525183,
0.023582915,
-0.0007329034,
0.007956308,
-0.021203822,
-0.009093853,
-0.018720726,
-0.025845002,
0.01833071,
-0.006597756,
0.013325517,
-0.013494523,
-0.020475794,
-0.02368692,
0.030369177,
0.01186296,
-0.039417528,
-0.024323944,
-0.033359293,
-0.025155976,
0.016614644,
0.016302632,
0.0029527396,
-0.015691608,
-0.014508563,
-0.013039506,
0.004975943,
-0.014625567,
-0.029303137,
0.014586566,
0.008859844,
0.011316939,
-0.0138325365,
0.036817428,
0.000322575,
-0.0005764911,
0.033489298,
-0.01856472,
0.01879873,
-0.00748179,
0.030811194,
0.0025139726,
-0.028003085,
-0.009262859,
0.019045739,
0.01341652,
0.016861655,
0.028939122,
-0.0025675995,
0.013072007,
0.0027528568,
0.0062109907,
-0.0123439785,
-0.0080473125,
-0.011706954,
0.016042622,
-0.005707221,
0.011472945,
-0.0059997328,
-0.011940963,
-0.0006305245,
0.017212668,
0.010257398,
-0.0040886584,
-0.019643761,
-0.0150935855,
0.0014268053,
-0.015158588,
0.0047874358,
0.009750378,
-0.027041048,
-0.007267282,
0.012096969,
0.018070702,
-0.0061784894,
0.009626874,
-0.014534564,
-0.010894422,
0.007910807,
0.017394675,
0.0060484847,
0.03580339,
0.029121129,
0.0007434663,
-0.018421715,
0.054082096,
0.0041114097,
-0.0071827783,
0.017108664,
0.011199934,
0.02345291,
0.0071567777,
0.014508563,
0.024895966,
0.021216823,
-0.0075987945,
0.010933424,
-0.016042622,
-0.007975809,
-0.016640645,
-0.002549724,
0.0051156986,
-0.014092547,
0.0009368488,
0.005547965,
0.060218334,
0.026859041,
0.01469057,
-0.025480988,
0.012226975,
-0.012707992,
0.0078003025,
0.009067852,
0.0063832477,
0.006162239,
0.013364518,
0.01956576,
-0.034243327,
-0.011388442,
0.03458134,
-0.010920423,
-0.002887737,
0.015184589,
-0.01599062,
0.008885845,
0.016315633,
0.029823156,
-0.037727464,
-0.030343177,
0.012772995,
0.0067667626,
0.0095748715,
-0.024687957,
-0.027041048,
-0.00033882563,
0.017602682,
0.021268824,
0.030135168,
0.0036206404,
-0.0034353833,
-0.0033671306,
-0.0063637467,
-0.002427844,
0.02087881,
-0.0144435605,
-0.00044567353,
-0.00042048507,
0.018460715,
-0.027977085,
-0.00062768057,
-0.002604976,
0.026911044,
0.016367635,
-0.011888961,
-0.033879314,
-0.028211094,
-0.011258436,
-0.014378558,
-0.026391024,
-0.002427844,
-0.038897507,
0.023829924,
-0.0015681859,
0.007007272,
0.021008816,
-0.008755839,
-0.014534564,
-0.004569677,
-0.010653913,
0.009587872,
-0.006006233,
0.05642219,
-0.008411326,
0.008846843,
0.030837195,
0.013988542,
0.004039907,
-0.0034971356,
-0.023127897,
0.023647917,
-0.01596462,
-0.002504222,
0.016107624,
0.0029267385,
0.0129355015,
0.00003971248,
0.029459143,
-0.013637529,
-0.018941734,
-0.000412766,
-0.010660414,
0.0057722237,
-0.018408714,
0.036713425,
-0.009802381,
0.018044699,
-0.006129738,
0.01882473,
0.008560832,
0.006493752,
-0.004020406,
0.0080668125,
0.014079546,
0.0017339422,
0.011693954,
-0.020319788,
-0.02265988,
0.00747529,
0.024856964,
0.007761301,
-0.017147666,
0.026430026,
0.011011427,
0.015938617,
0.008599834,
-0.0077157994,
-0.015119586,
-0.003298878,
0.018603722,
-0.009048351,
-0.014495562,
0.010939924,
0.0020540797,
-0.027795078,
-0.050103944,
0.0077353,
0.02038479,
-0.005281455,
-0.010237897,
-0.017576681,
0.024843963,
-0.000476956,
-0.020722803,
-0.0105694095,
-0.009698376,
-0.030395178,
-0.01264299,
-0.029979162,
0.008170817,
-0.0077027986,
-0.01392354,
0.017485678,
-0.007501291,
-0.00122611,
0.011251937,
0.015457599,
0.0036108901,
0.017082663,
-0.013312517,
-0.0026326021,
0.036765426,
0.008957348,
0.018343711,
-0.017368674,
-0.04849188,
0.0004119535,
0.002653728,
-0.0040366566,
-0.024089934,
-0.02421994,
0.032709267,
-0.009906384,
0.005976982,
-0.0040334063,
0.01625063,
-0.00003516738,
0.001326864,
-0.020813808,
0.016055623,
0.006266243,
-0.029095128,
-0.023543913,
0.011128431,
-0.014001543,
-0.030811194,
-0.0027203555,
-0.024037933,
0.0063279956,
0.018876731,
0.005434211,
-0.014612567,
0.013741533,
-0.025636993,
-0.0077938023,
-0.022906888,
-0.015691608,
-0.006035484,
-0.0147685725,
0.020488795,
-0.009607373,
0.002162959,
-0.004277166,
-0.0031233712,
0.018447716,
0.0046346798,
-0.011895461,
-0.019500757,
-0.0069552697,
0.0033200039,
-0.021931851,
-0.014092547,
0.0022279613,
0.038897507,
0.018993737,
-0.014638567,
-0.011193434,
0.011557449,
-0.007813303,
-0.0024440947,
0.007780802,
-0.029745154,
0.0039586537,
0.013520524,
-0.0014869326,
-0.027405063,
0.02628702,
-0.02862711,
-0.014885577,
0.01727767,
-0.003734395,
0.0057917247,
0.0074362885,
-0.0036726424,
-0.03140922,
0.024440948,
-0.029485144,
-0.008970348,
0.0013081757,
-0.0046834317,
0.05829426,
0.05517414,
0.025910005,
-0.03590739,
0.003484135,
0.0075987945,
0.0070982752,
0.009555371,
-0.004173162,
0.019201744,
-0.0063279956,
0.020397792,
0.0012984254,
-0.014859577,
0.014430559,
-0.008840343,
0.009516369,
0.0048166867,
-0.0064059985,
-0.0103094,
-0.016510641,
-0.025103973,
-0.04230364,
0.025142975,
-0.0055024633,
0.019890772,
-0.012506485,
0.008521831,
0.013754534,
0.02940714,
0.030993203,
0.0028032337,
0.0036531417,
0.00437467,
-0.014287554,
-0.019240746,
-0.00056674075,
-0.019032737,
-0.0010944799,
-0.01673165,
-0.018694725,
0.0012553611,
0.0096138725,
-0.0014511812,
0.02992716,
-0.0039034013,
0.011173934,
0.0030274924,
-0.03452934,
-0.007897806,
-0.010289899,
-0.038351487,
-0.010686414,
0.014014544,
0.0010920423,
-0.03484135,
-0.0044559226,
0.005986732,
-0.021554835,
0.012200973,
-0.019435754,
-0.016341634,
0.022360867,
-0.008073313,
0.0030616187,
-0.01959176,
0.019526757,
0.01417055,
0.008398326,
-0.014092547,
-0.016510641,
-0.00011842647,
0.0023612166,
0.028835118,
0.026651034,
0.01186296,
-0.00826182,
-0.00008826124,
0.0010116018,
-0.019890772,
-0.041393604,
0.009555371,
0.010718916,
-0.007299783,
-0.04617779,
-0.03151322,
-0.032371257,
0.02011178,
0.011492446,
0.007533792,
-0.000046593603,
-0.022802884,
-0.033957317,
0.02217886,
-0.009925885,
0.014742572,
0.0003688893,
0.0008222819,
-0.02295889,
-0.027379062,
0.005824226,
-0.0060582347,
-0.00800181,
0.024232939,
0.0053757085,
0.01626363,
0.015743611,
-0.0016949407,
0.014612567,
-0.008294322,
-0.009054851,
0.040275563,
-0.0060712355,
0.017654685,
0.020553797,
-0.016380636,
-0.0075467927,
-0.0013333642,
-0.00047776854,
-0.011193434,
-0.020813808,
-0.00091572304,
0.026001008,
0.01855172,
-0.0050636963,
0.003040493,
-0.008417826,
-0.011206435,
-0.0006061485,
-0.0072542815,
0.0046541807,
-0.014339556,
0.0015819989,
-0.008996349,
0.012493485,
0.015769612,
0.0051872013,
-0.010660414,
-0.010705915,
0.021255825,
-0.012025466,
0.011745956,
0.023998931,
0.018577721,
-0.0009002849,
0.00927586,
-0.012356979,
-0.02808109,
-0.0023628417,
0.00128705,
-0.054706123,
-0.013254014,
0.007956308,
-0.020449793,
0.011817458,
-0.0024197188,
0.023296904,
0.003792897,
0.016185628,
-0.01985177,
-0.03411332,
0.027665073,
-0.021164821,
0.0073062833,
0.03972954,
-0.016419636,
-0.0011180433,
0.0051644505,
0.009152355,
-0.01316951,
0.001626688,
-0.032319255,
-0.029589148,
-0.008820842,
0.009698376,
-0.008463328,
-0.0009945385,
-0.008612834,
-0.004793936,
0.009152355,
0.010179395,
-0.008833842,
-0.00028621423,
0.0047549345,
0.0105109075,
-0.0015324345,
-0.033645306,
-0.009990888,
-0.023920927,
-0.0147685725,
-0.042459648,
-0.006653008,
0.0002329934,
0.04225164,
0.007553293,
0.0038091477,
-0.03897551,
-0.00696177,
-0.035283368,
-0.015782611,
0.018941734,
0.023881925,
0.011810958,
0.020800807,
-0.005362708,
0.028809117,
0.0060972366,
-0.016809652,
0.00044851738,
-0.014781573,
0.021788845,
-0.01418355,
0.031097205,
0.011570449,
-0.022295864,
-0.008794841,
0.027431063,
-0.0011562323,
0.0036108901,
0.034347333,
-0.011420943,
0.010614912,
-0.015925618,
0.0017128164,
-0.011193434,
0.026911044,
0.023348905,
-0.0013033005,
-0.009061351,
0.030187171,
-0.016133625,
0.012317978,
0.0123439785,
-0.008021311,
0.019396752,
0.018239707,
0.0040041553,
-0.014521563,
-0.010686414,
-0.00978288,
0.015678609,
0.022750882,
-0.00028621423,
-0.0032647515,
-0.024349945,
-0.00954237,
-0.014846575,
-0.010257398,
-0.008924847,
-0.013910539,
-0.0028178592,
-0.011648452,
-0.01056291,
0.0048816893,
0.0038839006,
-0.010582411,
-0.0004712683,
0.00037173316,
0.0034191327,
0.00037904596,
0.018720726,
-0.0000338978,
-0.009659375,
-0.021190822,
-0.009496869,
-0.015015583,
-0.025649995,
-0.025871003,
0.0032127495,
-0.019630762,
0.00019795299,
-0.030109167,
-0.012408981,
0.012402481,
-0.011706954,
-0.006571755,
-0.03426933,
0.006220741,
0.2090481,
-0.035413373,
-0.011544447,
0.0068512657,
0.005209952,
-0.01859072,
0.029771155,
-0.019760767,
-0.0016721898,
0.0059997328,
0.028731113,
-0.016588643,
-0.009470867,
-0.0016835653,
0.0017859442,
-0.00014087265,
-0.0361154,
-0.006353996,
-0.026521029,
-0.008060313,
-0.0029023625,
0.0019452005,
0.02294589,
-0.006857766,
0.008216319,
0.016887655,
0.00244897,
0.018681724,
0.018395713,
-0.008417826,
-0.018603722,
0.00097178767,
0.00824882,
0.0021710843,
0.0038643999,
0.0015559979,
-0.021723842,
-0.0129355015,
0.002427844,
0.0040431567,
-0.0035133862,
0.013234513,
-0.017758688,
-0.014417559,
0.02141183,
0.007189279,
-0.0028259845,
-0.0132410135,
0.006025734,
0.00027829205,
-0.030499183,
0.0072542815,
0.024024932,
0.028523106,
0.0075467927,
0.03068119,
0.031279214,
-0.0015982495,
0.0138325365,
0.018486718,
-0.028731113,
-0.014742572,
-0.019578759,
0.021086818,
-0.003945653,
0.01856472,
-0.024167938,
0.001609625,
0.016796652,
-0.0061264876,
-0.012350479,
0.002832485,
-0.033567302,
0.0047549345,
0.011453444,
-0.022061856,
0.020527797,
0.01083592,
-0.0016884404,
0.016562643,
0.0009262859,
0.010627912,
-0.016861655,
0.012324478,
-0.022906888,
-0.02633902,
0.021450832,
0.0005882728,
-0.022594877,
0.02787308,
-0.0071567777,
0.007195779,
-0.014833575,
0.009977887,
0.019175744,
0.015249591,
0.013338517,
0.027093051,
-0.01186946,
-0.020852808,
-0.037727464,
0.075870946,
0.011654952,
0.025597993,
-0.011147932,
0.015184589,
-0.010861921,
-0.008989848,
-0.005811225,
-0.0033248789,
0.017147666,
-0.02860111,
0.00928236,
-0.016029622,
0.00009161293,
0.02476596,
-0.024232939,
0.00030754317,
0.016354633,
-0.0073257843,
0.008268321,
-0.038819507,
-0.0012204223,
0.031331215,
-0.01705666,
0.0050116945,
-0.037519455,
0.008567332,
0.014352556,
-0.011401442,
-0.019487755,
0.0101663945,
-0.00078490545,
0.009080852,
0.003064869,
-0.01729067,
0.0056682196,
-0.0090223495,
-0.0386635,
0.017043661,
-0.011056929,
-0.014859577,
0.00042089133,
0.03140922,
0.018941734,
-0.014521563,
0.0025074722,
-0.0008750964,
-0.015249591,
-0.011875961,
-0.015327594,
-0.009048351,
-0.022139858,
-0.0068707666,
0.017966697,
-0.022815885,
0.004251165,
-0.01755068,
-0.004082158,
0.029745154,
-0.01677065,
0.019747766,
-0.001883448,
-0.017745689,
-0.012701493,
0.007377786,
-0.16131026,
-0.008970348,
0.030083166,
-0.03538737,
0.023699919,
-0.018460715,
0.0062792436,
-0.020735804,
-0.009438366,
-0.0011960464,
0.027275058,
-0.0048361877,
-0.03411332,
-0.023634916,
0.01495058,
0.019149743,
-0.0077483007,
0.03710344,
0.037311446,
0.017342672,
0.012246475,
-0.023647917,
0.028549107,
-0.027561069,
-0.013728532,
0.017511679,
0.0005439898,
-0.02808109,
0.0018265708,
-0.0072087795,
-0.022230862,
-0.011141432,
0.011531447,
-0.007676798,
0.01959176,
0.024856964,
0.015834615,
-0.0010465406,
-0.024167938,
0.022841886,
0.035491377,
0.026105013,
0.016315633,
0.004325918,
-0.022854887,
0.0038253984,
0.0076702973,
-0.00012441889,
0.019266747,
0.0057884743,
0.026508028,
-0.0016063747,
-0.024817962,
0.0039066514,
0.026456026,
-0.008255321,
0.024401946,
-0.00063986855,
0.020462794,
0.0056194677,
-0.015912617,
-0.015158588,
0.02291989,
-0.0036141402,
-0.01597762,
-0.031591225,
0.00037092064,
0.012291976,
-0.014001543,
0.014846575,
-0.028159091,
0.02525998,
0.015743611,
-0.024440948,
0.027379062,
-0.006464501,
0.014599566,
0.013780534,
0.0031363717,
0.02860111,
0.002138583,
-0.018876731,
-0.009964886,
0.0043096673,
0.0027739825,
0.007579294,
0.017862692,
0.005622718,
-0.02247787,
-0.0031867486,
-0.010874921,
-0.029563146,
-0.010874921,
-0.03226725,
-0.0123049775,
0.028549107,
0.009152355,
0.009659375,
0.010101392,
-0.012818497,
0.013338517,
0.00619149,
-0.02009878,
-0.0075987945,
0.011947463,
-0.0076442966,
0.009243359,
-0.01859072,
0.023699919,
0.007767801,
-0.02447995,
0.011297438,
-0.0059899823,
0.0035751387,
-0.015873615,
0.015405597,
0.024310943,
-0.0024115935,
-0.0067342613,
-0.021034816,
0.07207479,
-0.012987504,
-0.012077468,
0.025090974,
-0.003991155,
-0.018122703,
-0.13094108,
-0.015665608,
0.020579798,
-0.013637529,
-0.0010757918,
0.029017126,
-0.0017160665,
0.0055804662,
-0.025975008,
0.02525998,
0.0037246444,
-0.017602682,
-0.025051972,
-0.0026358522,
0.015717609,
0.0002496503,
-0.007631296,
-0.025623994,
-0.023803923,
0.03125321,
0.002658603,
-0.0015169963,
-0.0017306921,
-0.0044429223,
-0.0043519186,
0.019630762,
0.0012171722,
0.030395178,
0.0031672479,
0.018915733,
0.01779769,
0.004660681,
0.008021311,
-0.016887655,
0.0058924784,
0.021528834,
-0.025155976,
-0.017901694,
0.03764946,
-0.0033671306,
-0.018642724,
0.02345291,
-0.0092693595,
-0.004361669,
0.009626874,
-0.027457064,
-0.034503337,
-0.009886883,
0.038507495,
-0.008495829,
-0.019305749,
-0.0144435605,
-0.03897551,
-0.003506886,
0.0061719893,
-0.0049304413,
-0.01341652,
0.0039586537,
-0.010764417,
0.006799264,
-0.0072542815,
-0.0231929,
-0.010341901,
0.0066107563,
0.009074352,
-0.009386364,
0.0031396218,
-0.0154185975,
0.018811729,
-0.019578759,
-0.014534564,
-0.025858004,
-0.03634941,
0.0058762277,
-0.009431866,
-0.010848921,
-0.008599834,
-0.018252708,
0.0046834317,
-0.011570449,
-0.014378558,
-0.007039773,
0.005281455,
-0.0180837,
0.046255793,
0.008385325,
0.0064840014,
-0.005336707,
0.013572526,
-0.014287554,
-0.0012082343,
0.040041555,
-0.0066562584,
-0.027405063,
0.019955775,
-0.00033577863,
0.008222819,
-0.027431063,
0.026989046,
0.045527767,
-0.015028583,
-0.00012259069,
-0.042069633,
0.00748179,
-0.008710338,
-0.0048296875,
0.023335906,
-0.014079546,
0.010445905,
-0.015145588,
0.04537176,
0.026937045,
-0.004221914,
0.02476596,
-0.01521059,
0.008801341,
-0.010042889,
-0.008281321,
0.0062012407,
0.0046996824,
-0.0021743344,
0.009886883,
-0.00055211515,
-0.024817962,
0.036739424,
0.023010893,
0.016679646,
0.015899617,
0.004589178,
0.02706705,
-0.0066400077,
0.0022637127,
0.008417826,
-0.01132994,
-0.027925083,
0.015041583,
-0.0011537947,
-0.009496869,
0.0009425366,
0.027197056,
-0.015834615,
0.051950015,
-0.025754,
-0.038351487,
0.02578,
-0.008632335,
-0.01703066,
-0.029797155,
-0.030395178,
0.030057166,
-0.0037311446,
-0.009113354,
0.032449257,
0.01289,
-0.006006233,
-0.031045204,
-0.0205928,
0.006994271,
-0.0072152796,
-0.015288593,
-0.03759746,
-0.033177286,
0.016562643,
-0.005135199,
-0.020189783,
-0.010972425,
0.01108943,
-0.019409753,
-0.036479414,
-0.005307456,
0.035231367,
0.005830726,
-0.025727998,
0.03580339,
-0.006786263,
-0.009704877,
0.004855688,
-0.010777418,
-0.030265173,
0.025858004,
0.013306016,
0.016913656,
-0.00054033345,
0.013897539,
-0.014495562,
0.018226707,
0.014885577,
0.014066545,
-0.027405063,
0.03299528,
0.0017388174,
-0.009119853,
0.015353596,
0.01470357,
0.0024635955,
0.01831771,
0.01934475,
0.015366596,
0.003789647,
0.013189011,
0.0064417496,
0.03785747,
0.01366353,
-0.011823959,
0.029745154,
0.0012537361,
-0.014378558,
-0.008729839,
-0.020605799,
-0.029615149,
-0.019435754,
0.029121129,
0.0111024305,
0.0103159,
0.019175744,
-0.003893651,
-0.0309412,
0.010751417,
0.011212935,
-0.0141965505,
-0.015509602,
0.027379062,
0.026859041,
-0.0025919755,
-0.0061719893,
-0.009457867,
0.009945386,
0.0037051437,
-0.0015405597,
-0.03151322,
0.026508028,
0.01340352,
0.020943813,
-0.0062337415,
-0.030239172,
-0.0070527736,
-0.007943308,
-0.032397255,
0.014885577,
-0.0073387846,
0.009405864,
0.04690582,
0.0071112756,
-0.012577988,
0.017212668,
-0.020306788,
0.028237095,
0.008365825,
0.019942774,
-0.039313525,
-0.033099283,
0.03320329,
0.0071567777,
0.016185628,
-0.028965123,
-0.018109702,
0.035257366,
-0.018733727,
-0.00038473366,
0.013364518,
-0.008307322,
0.022035854,
-0.0045046746,
-0.007761301,
0.0031054954,
-0.02037179,
-0.00076459214,
0.020969814,
0.0053237067,
0.00021430518,
-0.040379565,
0.0020833309,
-0.00929536,
-0.0438897,
-0.029095128,
0.01493758,
0.0058989786,
-0.0023043393,
-0.029823156,
-0.0034581341,
0.0117134545,
-0.0012399231,
0.0386375,
-0.023699919,
-0.026911044,
-0.011414442,
0.0035556378,
-0.030733192,
-0.017745689,
0.0061752396
] |
Pluripotent human embryonic stem (hES) cells can differentiate into various cell types derived from the three embryonic germ layers and extraembryonic tissues such as trophoblasts. The mechanisms governing lineage choices of hES cells are largely unknown. Here, we report that we established two independent hES cell clones lacking a group of cell surface molecules, glycosyl-phosphatidyl-inositol-anchored proteins (GPI-APs). The GPI-AP deficiency in these two hES clones is due to the deficiency in the gene expression of PIG-A (phosphatidyl-in | [
-0.022896841,
-0.0010511123,
-0.00982154,
-0.03834886,
-0.02000461,
0.00592506,
-0.0020486647,
0.020031389,
-0.03138608,
-0.0063803187,
0.018598663,
-0.010524513,
-0.017032037,
0.010029084,
-0.02017868,
0.0060455697,
0.017942555,
-0.00007092497,
-0.0041977544,
0.048685916,
-0.020968687,
-0.008797208,
-0.005305774,
-0.017822044,
0.00589828,
0.012707078,
0.010959687,
-0.024048379,
-0.016817797,
-0.009265857,
0.020366138,
0.005041322,
-0.020834787,
0.0048136925,
-0.009600606,
-0.010377224,
0.0051986543,
0.0039533875,
0.015304731,
0.022655822,
0.018799512,
0.010450868,
-0.0060489173,
0.0025457672,
-0.0024252576,
0.0024034989,
-0.015880499,
-0.0104642585,
-0.018518323,
0.03454611,
0.017848825,
-0.010624938,
-0.0068355775,
-0.009439926,
-0.024490248,
-0.00010303997,
-0.0053660288,
0.012512923,
0.0048706,
-0.018652223,
0.002073771,
-0.0035483409,
-0.017902384,
-0.003916565,
0.00980815,
0.023003962,
-0.0073243114,
0.0013055217,
0.0032035494,
-0.014072854,
0.026605863,
-0.0039466927,
-0.013148947,
-0.015224392,
0.014407603,
-0.023298541,
-0.028815206,
-0.010109425,
-0.016710678,
0.016764237,
0.0054798434,
-0.037411563,
-0.012901233,
0.017835435,
0.0020905084,
0.007471601,
0.014420994,
0.029109785,
0.017326616,
0.005797855,
0.045043845,
0.03537629,
0.004224534,
0.0032470666,
-0.017969334,
0.009968829,
-0.0066983304,
0.018103234,
-0.0013063585,
-0.022454973,
-0.015023542,
0.026538912,
-0.0013967408,
-0.020808008,
-0.03186812,
0.011763085,
0.017888995,
-0.0093261115,
0.02319142,
-0.008000504,
-0.008502629,
0.019013751,
0.008569579,
-0.041589234,
0.018759342,
-0.0009247445,
0.016911527,
0.01602779,
-0.018893242,
0.0046028006,
0.005074797,
0.0068623577,
0.015157442,
-0.021423945,
0.02728875,
0.028654527,
-0.016429488,
-0.0028621051,
-0.019027142,
-0.00040588333,
0.021316826,
0.0023516128,
-0.0035483409,
0.012044274,
-0.024557197,
-0.018357644,
-0.025025846,
-0.008730258,
-0.0014034358,
-0.021196317,
-0.0058078975,
0.017125767,
0.008629833,
0.024182279,
-0.015585921,
0.00093227637,
0.020406308,
-0.0012494512,
0.009667556,
0.022709383,
0.01594745,
0.00967425,
0.024329567,
-0.014206754,
-0.0062263343,
0.022414804,
0.0072372765,
0.02356634,
-0.024168888,
-0.004529156,
-0.018812902,
-0.026405012,
0.0090783965,
0.02297718,
0.02333871,
0.03119862,
-0.014916422,
0.025615005,
0.018478153,
0.0046965308,
-0.025708735,
0.00956713,
-0.02017868,
0.0031349258,
-0.013992514,
0.015170831,
0.0007820577,
0.02359312,
-0.035911888,
-0.037893604,
-0.0019214601,
0.022990571,
0.017098986,
0.0012034231,
-0.009259162,
-0.002132352,
0.019013751,
0.0039533875,
0.011408251,
-0.0125196185,
-0.013061912,
-0.0009607301,
0.00998222,
-0.003416115,
-0.6354342,
-0.042178392,
0.021035636,
-0.008582968,
0.02355295,
0.0272218,
0.00795364,
-0.0019264814,
-0.03532273,
-0.0043216115,
-0.018451372,
0.008562883,
0.005483191,
0.0024185625,
-0.0068824426,
-0.02763689,
-0.0010486017,
-0.029538264,
0.016657118,
0.0034010513,
-0.01996444,
0.0033859876,
-0.018973581,
0.024918726,
0.017326616,
0.021932764,
0.022468362,
-0.0066313804,
-0.0396343,
0.04035736,
-0.0003983515,
0.03492103,
-0.02734231,
-0.0064740484,
0.044695705,
0.028520627,
-0.030047083,
0.029109785,
0.011100282,
0.054550722,
-0.0071971067,
0.0012343875,
0.003849615,
0.0071703265,
-0.00058832165,
0.020299189,
-0.005623786,
0.0062296814,
0.0037692755,
0.00971442,
0.010618243,
0.0023583078,
-0.02774401,
0.012271903,
-0.008629833,
-0.0090783965,
0.008850767,
0.0042011016,
0.019161042,
0.0010778923,
0.013938954,
0.029859625,
-0.021758694,
-0.013102082,
-0.005359334,
0.02747621,
-0.010390613,
0.004107372,
-0.0051718745,
-0.03561731,
0.012184869,
0.018357644,
-0.01971003,
0.004398604,
-0.009694335,
0.026311284,
0.009071702,
-0.001336486,
-0.0019164389,
-0.010671803,
0.009192212,
0.0038194878,
-0.020700887,
0.026217554,
0.013751495,
-0.000684562,
-0.021156145,
0.011414946,
-0.00074481685,
0.010116119,
0.015331511,
0.017554246,
0.016001008,
-0.045204524,
-0.024128718,
0.010256714,
-0.010571378,
0.0046898355,
-0.0036454182,
-0.025440935,
-0.020071559,
0.0037826654,
0.00950018,
0.022307683,
0.031493198,
0.010892738,
-0.03939328,
0.00581794,
0.040062778,
-0.03446577,
-0.0073243114,
-0.01176978,
0.009975525,
-0.010718668,
0.0053526387,
-0.022776332,
0.015371681,
0.0072305817,
-0.0072372765,
-0.032376938,
0.008395509,
-0.011160537,
-0.020111728,
0.018116623,
0.013430136,
0.022816502,
-0.0076724505,
-0.021986324,
0.0099956095,
0.005530056,
-0.00089294335,
-0.003849615,
0.0029006014,
-0.028788427,
0.03143964,
0.020995466,
0.0053861137,
-0.0060254848,
0.022508532,
-0.010839177,
-0.022053273,
-0.008288389,
0.010424089,
-0.01922799,
-0.018679002,
-0.02297718,
-0.0014452795,
-0.016429488,
0.026485352,
-0.002785113,
0.012928012,
0.0044655534,
0.003772623,
0.016509827,
0.020888347,
-0.009774675,
-0.013831835,
-0.021825645,
0.012432584,
-0.0064606587,
-0.016804406,
0.018679002,
-0.0071703265,
0.0016293915,
-0.007043122,
-0.017380176,
-0.0142603135,
-0.005489886,
-0.012412499,
-0.021959543,
0.007545246,
0.00030169266,
-0.0036889357,
0.015371681,
-0.008221439,
0.019067312,
0.0141933635,
0.0072841416,
-0.01938867,
-0.0037157156,
-0.014675403,
-0.015452021,
-0.0068623577,
-0.0009331133,
0.03138608,
0.0076858406,
0.022080055,
0.019937659,
0.005463106,
0.020419698,
0.0038395727,
0.0024788175,
-0.0053626816,
0.026378233,
-0.0064606587,
-0.011890289,
0.009239077,
0.014434383,
-0.0012419194,
0.03518883,
0.037893604,
-0.017701535,
0.0021608057,
-0.007103377,
0.026230942,
-0.04274077,
-0.013450221,
-0.009580521,
-0.018585272,
0.018022895,
-0.006002052,
0.01152876,
-0.008107624,
0.0011565583,
-0.0056639556,
-0.025655175,
-0.003685588,
-0.0059987046,
-0.005653913,
-0.006336801,
0.008228134,
0.009051617,
0.016268808,
0.0072171916,
-0.002534051,
0.008569579,
0.017500686,
0.029404365,
-0.012981572,
-0.008931107,
0.012874452,
0.012486143,
0.009962135,
0.016831188,
0.01981715,
0.02774401,
0.020419698,
-0.0073912614,
0.03655461,
-0.010899432,
0.005556836,
0.021008857,
0.0018109928,
0.002738248,
-0.0003387243,
-0.012961487,
0.020982077,
0.0014101308,
-0.024758046,
0.02340566,
-0.024891946,
0.017982725,
-0.01992427,
0.021477506,
0.006279894,
-0.014300483,
0.0031232096,
0.026311284,
0.014581673,
0.007612196,
0.010223239,
-0.020352747,
-0.0062564616,
-0.0054597585,
-0.0019833888,
0.0026746457,
0.0029893098,
-0.009895185,
-0.026632642,
-0.01194385,
-0.018571883,
0.007143547,
-0.0064539635,
-0.019147651,
-0.008455764,
-0.0058681527,
0.018156793,
-0.01585372,
0.017634585,
0.0016168384,
-0.010651718,
-0.029565046,
0.013845225,
0.034331873,
-0.011515371,
0.0038931326,
-0.033180337,
-0.020714277,
-0.012325464,
0.004542546,
-0.0013389966,
0.0038127927,
0.027101291,
0.0069426973,
-0.020968687,
-0.030663023,
-0.0038529627,
0.0020754447,
0.038375642,
0.0025658521,
0.018625442,
-0.010410698,
-0.0156127,
-0.004134152,
0.052997485,
0.0310915,
-0.0069226124,
-0.0038663526,
0.0071837166,
-0.03958074,
-0.0045492407,
-0.028359948,
0.002778418,
0.00003454716,
0.00073937717,
0.0025240085,
0.003508171,
0.010973077,
0.030047083,
-0.006279894,
-0.022776332,
-0.03170744,
-0.008536103,
-0.004666403,
0.027020952,
0.037116986,
-0.010176374,
0.016724067,
0.009004752,
0.00016611927,
-0.009446621,
-0.014662012,
0.012559788,
-0.009399756,
-0.007451516,
0.0042513143,
0.0056505655,
-0.028413508,
0.011314522,
0.021504285,
-0.012847672,
-0.018571883,
0.0057878126,
0.00047701754,
0.008147794,
-0.0063501913,
-0.0010645023,
0.028975885,
0.01570643,
0.00032324216,
0.009560436,
-0.0068154926,
-0.010116119,
0.004746743,
-0.03213592,
0.0014260313,
-0.012573178,
-0.0065376507,
-0.00403038,
-0.04303535,
0.0027968292,
0.0016126541,
0.007049817,
0.020513428,
0.0018126667,
0.024744658,
-0.0034060725,
-0.0059284074,
-0.00971442,
-0.0040370747,
-0.013965734,
0.0016009378,
-0.010524513,
-0.033233896,
0.012613348,
-0.025467714,
-0.0046563605,
-0.016469657,
0.015277951,
-0.007069902,
-0.013818445,
-0.0063167163,
0.0015917321,
-0.026940612,
-0.009071702,
-0.010410698,
0.010879347,
0.0021239833,
-0.0010159636,
-0.026016703,
0.009841625,
-0.017299837,
-0.037545465,
-0.0035382984,
0.020031389,
-0.021022247,
-0.033046436,
-0.004398604,
-0.0039132177,
0.025708735,
-0.000023746268,
-0.008348644,
0.0048940326,
0.021986324,
0.013738105,
-0.02774401,
0.005623786,
-0.01571982,
0.006373624,
0.010946297,
-0.00246208,
-0.016710678,
-0.012251819,
-0.013195812,
0.010986467,
-0.024985677,
-0.00963408,
-0.005714168,
-0.030475562,
0.008763732,
0.030127423,
-0.008890937,
-0.0041810167,
0.0005682367,
-0.021049026,
-0.03446577,
-0.014568283,
-0.029431146,
0.002040296,
0.006614643,
-0.012459363,
0.005074797,
-0.022133613,
-0.0031215358,
0.020540208,
-0.0072640567,
0.021999715,
0.0017925816,
0.028279608,
0.014313874,
-0.0058279824,
0.01972342,
-0.0019315026,
-0.011006552,
-0.012834283,
-0.020500038,
0.03628681,
0.005633828,
-0.021839034,
0.0071301567,
0.016603557,
-0.016804406,
-0.026686203,
-0.020165289,
-0.017032037,
0.030663023,
0.0016938307,
-0.00799381,
-0.005673998,
-0.0025876109,
-0.024744658,
0.007491686,
0.0051953066,
-0.017058816,
0.014862862,
0.008911022,
0.014126414,
-0.005396156,
0.021932764,
-0.041937374,
-0.0061593843,
0.02782435,
-0.011301131,
0.0053359014,
-0.0011607427,
0.013885395,
-0.0056137433,
-0.011408251,
-0.020647328,
-0.012439278,
-0.00781974,
-0.020017998,
0.033528473,
0.04691844,
0.025775684,
0.008696782,
0.03411763,
0.021664964,
0.020125119,
0.014956592,
-0.00998222,
0.01148859,
-0.024704488,
0.0321627,
-0.012680298,
-0.009352891,
0.02744943,
-0.010377224,
0.009473401,
0.021557845,
-0.013095386,
-0.015746599,
0.016898137,
-0.04300857,
-0.053211726,
0.016175078,
-0.007103377,
0.011649271,
-0.03526917,
-0.010591463,
-0.014702182,
-0.0051953066,
-0.013751495,
-0.015130661,
0.037973944,
-0.008234829,
0.032430496,
-0.0051584844,
0.014822693,
-0.0068757473,
-0.009292636,
-0.005714168,
-0.002401825,
-0.0043383488,
0.0060522645,
0.012305379,
-0.0076322807,
-0.012974877,
0.0042847893,
0.029136566,
-0.027583329,
-0.0036956307,
-0.014340653,
-0.033742715,
-0.0043216115,
-0.014461163,
-0.018598663,
-0.020754447,
0.010778923,
0.008830682,
-0.021825645,
0.014220144,
-0.022682602,
-0.020325968,
0.020473259,
-0.0069226124,
0.033823054,
-0.002679667,
0.01584033,
0.044294007,
0.01593406,
-0.045097407,
-0.01148859,
0.0034546112,
0.01582694,
0.024583977,
-0.003555036,
0.01570643,
-0.040785838,
-0.009707726,
0.033207115,
-0.022816502,
-0.0318949,
0.011086891,
-0.017714925,
-0.011194011,
0.0029658775,
-0.005918365,
-0.024758046,
-0.0009540351,
-0.00070255477,
0.024771437,
-0.0032537617,
-0.017848825,
-0.01922799,
0.03877734,
0.0043952563,
0.020888347,
0.010424089,
0.015130661,
-0.012499534,
-0.041026857,
-0.007029732,
0.017647974,
0.010350443,
0.0196163,
-0.024999067,
-0.0012620043,
0.0072305817,
-0.006149342,
0.009192212,
0.005285689,
0.01938867,
0.03877734,
-0.010450868,
-0.01972342,
0.02356634,
0.0062564616,
0.02724858,
-0.024677707,
-0.010497733,
-0.009225686,
-0.037438344,
-0.010906127,
0.0384292,
0.0069025275,
0.005151789,
-0.016134908,
-0.022026494,
-0.0068188403,
-0.048177097,
-0.033153556,
0.0029441188,
-0.02324498,
-0.0032420454,
0.006035527,
0.009105177,
0.007719315,
-0.011374776,
0.0043885615,
-0.0042144917,
0.0316271,
-0.001428542,
0.017594416,
0.009855015,
-0.0034981286,
-0.033582035,
-0.001750738,
0.001441095,
-0.020848177,
0.000232023,
-0.018906632,
-0.021156145,
-0.0033207114,
0.0062062494,
0.018772732,
0.018304083,
-0.007578721,
-0.0052287816,
-0.0021574583,
0.041133974,
0.008315169,
-0.014849472,
0.008261609,
-0.022923622,
-0.0058815423,
-0.0024754698,
-0.013704631,
-0.011495286,
-0.012934707,
-0.014662012,
0.006812145,
-0.016549997,
-0.017045427,
-0.012486143,
-0.01341005,
-0.020513428,
0.004612843,
-0.017005257,
-0.0134569155,
-0.01008934,
0.0026143908,
0.0010368855,
-0.02406177,
-0.035644088,
-0.003081366,
0.008027284,
0.016563388,
-0.0051250095,
-0.0127874175,
-0.008562883,
-0.008428983,
-0.02384753,
0.010772227,
-0.0056773457,
0.05133713,
0.030154204,
-0.012928012,
-0.01610813,
0.006457311,
-0.04266043,
-0.014996761,
0.00035880925,
0.008502629,
0.0065276083,
0.018612053,
0.004753438,
-0.01593406,
0.004800303,
-0.008736953,
-0.0060857395,
-0.03982176,
0.0198841,
-0.015224392,
-0.0010327011,
0.018451372,
-0.03518883,
-0.012211649,
0.0389648,
-0.0038697002,
-0.00796703,
0.020955296,
-0.002244493,
0.041482113,
0.0044220365,
0.024383128,
0.018237134,
0.027114682,
0.010082644,
-0.01917443,
-0.009828235,
0.008355339,
-0.011481896,
-0.028734867,
-0.0029575087,
0.0022311031,
-0.008435679,
0.008194659,
-0.003956735,
-0.009372976,
-0.0024403213,
0.004291484,
0.016041178,
-0.0030328273,
-0.0025307036,
0.0073443963,
0.028520627,
0.01198402,
-0.0066280332,
0.007190412,
-0.009031532,
0.014528113,
-0.005971925,
-0.013336406,
0.00047241474,
-0.014702182,
0.0027683754,
-0.028895546,
-0.0072774463,
0.003508171,
-0.0051651793,
-0.0013507128,
0.025615005,
-0.016791018,
-0.014929812,
-0.020633938,
0.009399756,
0.000533088,
-0.033448134,
0.0020570336,
0.0034914336,
-0.018973581,
-0.0019867362,
-0.014903032,
0.00072975317,
-0.022642432,
0.009647471,
-0.004488986,
-0.01567965,
-0.00023055848,
0.19292262,
-0.0069293072,
0.02363329,
-0.018504933,
0.00806076,
-0.0156127,
-0.00067912234,
0.0115354555,
0.014621843,
0.0010653392,
0.007063207,
-0.005379419,
-0.009533656,
-0.0004606985,
0.021785475,
-0.01575999,
-0.026137214,
0.0035115185,
-0.0123857185,
-0.0053526387,
0.006530956,
-0.021705134,
0.034251533,
-0.010557988,
0.016857967,
-0.006142647,
-0.024758046,
0.0077795703,
0.009239077,
0.014889642,
-0.024276009,
-0.0038697002,
-0.005570226,
0.007973725,
0.034064073,
-0.00030336643,
-0.0039466927,
-0.008248219,
0.010919517,
0.0008912696,
0.0061392994,
0.011743,
0.013182421,
0.010350443,
-0.0032872367,
0.008964582,
0.004509071,
-0.014581673,
0.012620043,
-0.0006205412,
-0.036929525,
0.009131957,
0.005744295,
0.0051986543,
0.000585811,
0.0053526387,
0.008067454,
0.022816502,
-0.0067485427,
0.027931469,
-0.0022629043,
0.015371681,
-0.025775684,
0.010122814,
-0.009921965,
0.01972342,
-0.010959687,
-0.01992427,
0.007331006,
-0.013222591,
0.007719315,
-0.00044856386,
-0.01567965,
0.004686488,
-0.013872005,
-0.021022247,
0.04249975,
0.013102082,
0.010176374,
0.010852567,
0.010966382,
0.016670508,
-0.036527827,
-0.002277968,
-0.007980419,
-0.04370485,
0.05042661,
0.02355295,
-0.026672812,
-0.011354691,
0.0096608605,
0.0011071828,
-0.0021541107,
0.0026813408,
0.008455764,
-0.0043082214,
0.000023275526,
0.0038596576,
-0.0012260188,
-0.020700887,
0.000015665213,
0.050239153,
0.0080741495,
0.019294942,
-0.021624794,
0.03119862,
0.0010502754,
-0.002863779,
-0.007538551,
-0.0014854494,
-0.016576778,
-0.011749695,
-0.004345044,
-0.0012678624,
0.0058279824,
0.03127896,
0.016911527,
-0.010678498,
0.04432079,
-0.004733353,
0.0018511628,
-0.015960839,
0.018344253,
0.036501046,
0.004622886,
0.013282846,
-0.013148947,
0.009881794,
-0.006497481,
-0.03146642,
-0.016255418,
-0.005325859,
0.0121179195,
0.009721115,
0.005024585,
-0.0028788426,
0.0059417975,
0.009654165,
-0.022655822,
0.01973681,
-0.020392919,
-0.0051450944,
-0.009232381,
0.006303326,
0.009828235,
-0.011890289,
0.024824997,
0.020272408,
-0.018585272,
-0.016228639,
-0.018424593,
-0.028815206,
-0.008415594,
-0.012318769,
0.030314883,
-0.030127423,
-0.018170184,
-0.014675403,
0.007364481,
0.007505076,
-0.025815854,
0.026900442,
0.00051635056,
-0.0192146,
-0.0038362253,
-0.014836082,
-0.16903493,
-0.0017473906,
0.015036931,
-0.021356996,
0.022401413,
0.0049342024,
0.0020754447,
-0.01979037,
-0.0053995037,
-0.0021340258,
0.04266043,
-0.0034780437,
-0.040598378,
-0.03267152,
0.015010152,
0.017098986,
-0.016777627,
0.036152907,
0.004686488,
0.0037291055,
0.030100644,
-0.023124471,
0.029591825,
0.011053417,
0.0057878126,
0.01194385,
0.0076925354,
-0.010136204,
-0.013885395,
-0.021464115,
-0.0017658018,
0.0040973295,
0.037973944,
0.021115975,
-0.0001607842,
-0.01606796,
-0.0040035998,
-0.011642575,
0.0047969553,
0.018826293,
0.028868767,
0.0071301567,
-0.010705277,
-0.004013642,
-0.00068832794,
0.0145950625,
-0.0096073,
-0.00048036504,
0.03465323,
-0.008208049,
0.0142603135,
-0.016549997,
-0.00336925,
0.024731267,
0.010745448,
0.012807502,
0.017433736,
0.019013751,
0.0073912614,
-0.014139804,
-0.003220287,
-0.008542798,
0.025266865,
-0.0141933635,
0.003041196,
-0.028681306,
0.017795265,
-0.0006916754,
-0.033876613,
0.008114319,
-0.017125767,
-0.021517675,
0.012586568,
-0.045338426,
0.0465703,
0.008931107,
-0.007786265,
0.008114319,
0.0018310779,
-0.009620691,
-0.023392271,
0.014046074,
-0.024222448,
-0.022843283,
-0.016683897,
0.0022093444,
-0.009065007,
0.011160537,
-0.0042814417,
-0.0073109213,
0.013992514,
-0.02008495,
-0.0019331763,
-0.015492191,
0.010544598,
0.028440287,
-0.017902384,
-0.023352101,
-0.0080071995,
-0.00043601077,
0.033073217,
-0.0039333026,
-0.018759342,
0.024235839,
0.0396343,
-0.0073443963,
-0.024650928,
0.0063434965,
0.06711051,
-0.0069226124,
-0.025240086,
-0.0032286556,
0.008335254,
0.03224304,
-0.002000126,
0.045177747,
-0.0111337565,
0.0072908364,
0.016965088,
-0.037116986,
0.0627186,
0.0049978048,
-0.008549493,
0.04646318,
0.001277068,
-0.01580016,
-0.12854367,
-0.021290045,
0.01602779,
0.015371681,
-0.01175639,
0.024128718,
0.008355339,
0.003665503,
-0.01586711,
0.033582035,
-0.02013851,
-0.02769045,
0.0099956095,
-0.026646033,
0.033287454,
-0.004753438,
-0.00037010704,
-0.0063769715,
-0.025132965,
0.02328515,
0.010337054,
0.0033207114,
-0.021624794,
-0.021664964,
0.020687498,
0.007511771,
-0.026846882,
0.036688507,
0.033019654,
0.022816502,
0.0069159176,
-0.011937154,
0.00769923,
0.013128862,
-0.008904328,
-0.017527465,
-0.004211144,
-0.013296236,
0.028306387,
-0.0043751714,
0.0030847134,
0.0122049535,
0.008194659,
-0.016670508,
-0.009560436,
-0.00982154,
-0.021410555,
-0.011461811,
0.009948744,
-0.029484704,
-0.052729685,
-0.03548341,
-0.019080702,
0.0029642037,
0.02340566,
-0.01554575,
0.008663308,
0.0312254,
0.00032784496,
-0.002376719,
-0.00038537994,
-0.0197502,
-0.010236629,
-0.007980419,
0.030555902,
0.0007121788,
-0.038911242,
-0.03984854,
0.030154204,
-0.024530418,
-0.0073778713,
0.027985029,
-0.012526313,
0.0019967787,
-0.03186812,
-0.0014143152,
0.0025641785,
-0.0052823415,
0.0044655534,
0.00018923788,
0.0021641531,
-0.026364842,
0.029511485,
0.009004752,
0.02752977,
0.008870852,
0.030073863,
-0.0065409984,
0.0137916645,
-0.012599958,
-0.0016335759,
0.03438543,
0.0035115185,
-0.026271112,
-0.0034144414,
0.0036387232,
0.00791347,
-0.0009398082,
0.025708735,
0.020312577,
-0.026659422,
-0.013075301,
-0.061700962,
0.01569304,
-0.013041827,
-0.0025357248,
-0.00029081333,
-0.019977828,
0.0010921191,
-0.010859262,
-0.003665503,
0.0063434965,
-0.0122049535,
-0.00022449114,
-0.021276657,
-0.0026579082,
-0.021209706,
-0.011562236,
0.03510849,
0.001770823,
0.010792312,
0.03275186,
-0.022682602,
-0.01926816,
-0.012894537,
-0.003146642,
-0.011736305,
0.0051919594,
-0.012653518,
0.018585272,
0.00496433,
-0.021356996,
0.0076389755,
-0.04351739,
-0.014220144,
-0.0038395727,
-0.0041174144,
-0.016429488,
0.012479449,
0.018558493,
0.037518684,
0.02755655,
-0.014300483,
-0.02769045,
0.018317474,
0.0017892342,
0.00015063712,
-0.0072707515,
-0.014608453,
0.008830682,
0.0021942807,
-0.028493848,
0.04399943,
0.011763085,
0.0017490643,
-0.009419841,
-0.0057242103,
-0.021892594,
0.0058212876,
-0.0066782455,
-0.011287741,
-0.014742352,
0.043919086,
0.021598015,
0.025280256,
-0.014983372,
-0.00978137,
-0.008368729,
-0.02333871,
-0.0072372765,
-0.020700887,
-0.028975885,
-0.018277304,
-0.00037722045,
0.0050647547,
0.03545663,
0.020687498,
0.003752538,
-0.001362429,
0.018424593,
-0.0062765465,
0.00021340259,
-0.00388309,
0.00071050506,
-0.026485352,
0.013463611,
0.0238877,
-0.00036027376,
-0.003081366,
0.020259019,
-0.012914622,
0.003054586,
-0.001941545,
0.028600967,
-0.0035182135,
0.0033926826,
0.012158089,
-0.0032939317,
-0.001369124,
0.010270104,
0.009165431,
0.025789075,
-0.008107624,
0.015117272,
0.024824997,
-0.025360595,
-0.018424593,
0.014153194,
-0.03178778,
-0.038241744,
-0.011930459,
-0.019080702,
0.0054028514,
0.018799512,
-0.003245393,
-0.00012124196,
-0.021490896,
-0.0010159636,
0.020325968,
-0.013764885,
-0.010618243,
0.02406177,
0.013316321,
0.021303436,
-0.006601253,
-0.01586711,
0.017232886,
0.0004514929,
0.030395223,
-0.011676051,
0.026887052,
-0.023486,
0.012887842,
0.00058999535,
-0.015103881,
-0.02383414,
-0.0016243702,
-0.012392414,
-0.008094234,
0.008388814,
-0.017165937,
0.08976633,
-0.010316969,
-0.013751495,
0.009426536,
-0.008208049,
0.024356348,
-0.00034751146,
0.014514723,
-0.025320426,
-0.026364842,
0.024450079,
-0.025976533,
0.022722771,
-0.021464115,
-0.008723563,
-0.0044588586,
-0.012171479,
0.0017013625,
-0.017768485,
-0.0006259809,
0.009192212,
-0.020821396,
0.021236487,
0.024503637,
-0.016884748,
0.0058882376,
0.027717229,
0.004596106,
0.021531066,
-0.01586711,
0.017259667,
0.008509323,
-0.06357556,
-0.0050781444,
-0.010517818,
0.010470954,
0.002441995,
-0.029431146,
0.030100644,
0.007960334,
-0.0025976533,
0.01194385,
-0.009111872,
-0.015425241,
-0.0011473527,
-0.0089913625,
-0.033715934,
0.008944497,
0.0010519492
] |
Horizontal gene transfer (HGT) in bacteria and archaea occurs through phage transduction, transformation, or conjugation, and the latter is particularly important for the spread of antibiotic resistance. Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci confer sequence-directed immunity against phages. A clinical isolate of Staphylococcus epidermidis harbors a CRISPR spacer that matches the nickase gene present in nearly all staphylococcal conjugative plasmids. Here we show that CRISPR interference prevents conjugation and plasmid transformation in S. ep | [
-0.0144225685,
-0.003528997,
0.010137119,
-0.0042121364,
-0.0038922273,
0.029218365,
0.018821318,
0.0073312502,
-0.010483688,
-0.022460284,
0.0055417586,
-0.006871381,
-0.0043354346,
0.02199375,
0.0066481107,
0.012369818,
0.029831523,
0.003000814,
-0.012596421,
-0.010183773,
-0.038815636,
0.00016609863,
0.0028825141,
-0.0013479503,
-0.008650875,
0.021180648,
0.02609925,
-0.03724275,
-0.02525949,
0.0027842089,
-0.00026971503,
0.012896336,
-0.018074865,
0.010457029,
-0.021500558,
-0.03782925,
0.02871184,
-0.015035727,
0.006424841,
-0.011903284,
0.01378275,
0.0016453657,
-0.0041621504,
-0.008104363,
0.0151556935,
0.0153822955,
0.007851102,
-0.019834364,
-0.0015087379,
0.004941929,
0.023539977,
0.017834932,
-0.022660227,
0.0034790114,
-0.010243756,
-0.0073978975,
0.012989642,
0.006208236,
0.00659146,
-0.013902716,
-0.0094573125,
0.0051085483,
-0.03172432,
0.009450648,
-0.016182069,
0.0070713237,
0.01040371,
-0.0024526364,
0.0042121364,
0.0057317046,
0.031297773,
0.024366409,
0.027778773,
0.00093473436,
0.020700784,
-0.021020694,
0.0005048565,
-0.0032574076,
-0.010450364,
0.011270131,
0.01232983,
-0.0065781306,
0.012396477,
0.005261838,
0.007597841,
-0.008744182,
0.010703625,
0.01638201,
-0.0075245285,
-0.0021543878,
0.005738369,
0.027432205,
-0.0070513296,
0.027352227,
-0.017115137,
0.009137403,
0.00659146,
0.009150733,
0.016062103,
-0.018248148,
-0.0053184885,
0.005475111,
-0.011676682,
-0.019487796,
-0.03758932,
0.016955182,
0.0111501645,
-0.017621659,
0.0046353494,
-0.029564932,
-0.015475602,
0.031457726,
-0.0058083492,
-0.053211547,
0.021807136,
-0.004648679,
0.030791251,
-0.01302963,
-0.012689727,
-0.028098682,
0.021927102,
0.010523676,
-0.0042587896,
-0.030444682,
0.03409698,
0.034203615,
-0.017061818,
0.004741986,
-0.0055317613,
-0.015662216,
0.015115704,
0.0034623495,
0.014449228,
0.00036614595,
-0.013269562,
0.0005815014,
-0.025299478,
-0.030711273,
-0.014809125,
-0.040388525,
-0.0014637507,
0.022646898,
-0.009264034,
0.007324585,
0.00793108,
0.01039038,
0.023073444,
0.015182353,
0.011496733,
0.015582238,
0.014089329,
0.004908605,
0.019541115,
0.011610034,
0.0058516706,
0.011450079,
-0.01704849,
-0.004392085,
-0.019114569,
-0.022073727,
-0.019967658,
-0.014115988,
0.00911741,
0.01582217,
0.009024102,
0.024446387,
-0.015502261,
0.005408463,
0.009344012,
-0.026352512,
-0.0033573792,
0.006468162,
-0.036736228,
0.017501693,
-0.0013646123,
0.023286715,
-0.0028775157,
0.0024159802,
-0.011676682,
-0.03193759,
-0.00911741,
0.0033607117,
0.04609357,
0.016555296,
-0.007271267,
-0.010437034,
0.014875772,
-0.0046853353,
-0.012909665,
-0.024153136,
-0.004815298,
0.0071712956,
0.014609182,
-0.016222056,
-0.62232983,
-0.021513887,
-0.012223193,
-0.018874636,
0.02371326,
0.019021261,
0.017128466,
0.010856915,
-0.025406113,
0.039775364,
-0.0070846532,
0.01934117,
-0.0041621504,
-0.014036012,
-0.028205318,
-0.03721609,
0.014315932,
-0.016941853,
0.03956209,
0.02347333,
-0.004338767,
-0.007018006,
-0.010443699,
0.012696392,
-0.0015712202,
0.012989642,
0.013822739,
0.0015845497,
-0.0012912997,
0.009783886,
-0.016888535,
0.0009164063,
-0.023006795,
-0.023393352,
0.055024363,
0.018128183,
0.0093306815,
0.03052466,
0.019807704,
0.028152,
-0.01039038,
-0.015089045,
0.029431637,
0.030737933,
0.0045653693,
0.019154556,
-0.0029008423,
-0.008630881,
-0.012449795,
-0.0076111704,
0.004978585,
0.017168455,
-0.01844809,
0.011643358,
0.0077511305,
0.009204051,
0.023233397,
-0.017341739,
0.022127045,
0.012136552,
0.0040721763,
0.03425693,
-0.0018178168,
-0.033617113,
-0.0007868597,
-0.015662216,
-0.019967658,
0.00068272266,
0.01115683,
-0.014995739,
0.019141227,
0.02699233,
0.005415128,
0.0040688436,
-0.012049909,
0.0357765,
-0.0070246705,
-0.010370387,
-0.013876057,
0.031617682,
0.0000880479,
-0.018768,
-0.03958875,
0.008970784,
0.041428227,
0.011250136,
-0.014582523,
0.01336287,
-0.020020977,
-0.028418591,
0.011876625,
0.027178943,
-0.032977294,
-0.030657955,
-0.029431637,
0.0010113793,
-0.022726875,
-0.024446387,
-0.0065248124,
-0.011823307,
-0.02525949,
-0.015235671,
0.0002311843,
0.0107836025,
0.02937832,
0.0019544447,
-0.019021261,
0.021553876,
0.026952341,
-0.013676113,
-0.023353364,
-0.00032844834,
-0.010930227,
0.016328692,
-0.00995717,
-0.021900443,
0.030044796,
0.025379455,
-0.0045487075,
-0.042094704,
0.026885694,
-0.002492625,
-0.0075711817,
-0.0024293098,
0.029778205,
0.020674124,
-0.0045053866,
-0.03646964,
-0.0027875411,
-0.0026059262,
0.005715043,
-0.030444682,
0.010450364,
-0.012962983,
0.0057050455,
0.015448944,
0.019741056,
0.006184909,
0.020194262,
-0.015795512,
-0.013609466,
-0.007911085,
0.021887114,
0.013542818,
-0.02937832,
-0.018021546,
-0.012136552,
-0.009064091,
-0.000019655872,
-0.02759216,
0.031830955,
0.0039788694,
-0.013462841,
0.004675338,
0.009757227,
-0.008284313,
-0.040255226,
-0.03337718,
-0.018674694,
-0.02493958,
0.0056883837,
0.014929091,
-0.00006248224,
-0.0087375175,
-0.015728863,
-0.012443131,
0.026419159,
0.009670585,
-0.0010055476,
-0.038335774,
0.012369818,
-0.025139524,
-0.019714398,
0.019247863,
-0.010716954,
0.030124772,
-0.020727443,
0.024593012,
0.005408463,
0.00907742,
-0.0059849657,
-0.016608614,
-0.013636125,
0.004871949,
-0.0027708793,
-0.007857767,
0.02199375,
-0.0034990057,
0.032737363,
0.04721325,
-0.013996023,
0.012976313,
-0.008470926,
0.0058849943,
-0.005588412,
-0.009250704,
0.017061818,
0.012516444,
-0.00543179,
0.01758167,
0.029644908,
-0.0126030855,
-0.00077561295,
-0.051851932,
0.025126193,
-0.034176953,
-0.0046120225,
-0.0053418153,
0.028258637,
-0.003528997,
0.0008147685,
0.013262898,
-0.019207874,
0.0012971314,
-0.0073312502,
0.00039134713,
-0.024766296,
0.017994886,
-0.0078644315,
-0.0010213765,
-0.019621091,
0.02078076,
0.026459148,
0.00035323296,
-0.023233397,
0.026205886,
0.009430653,
-0.008404278,
-0.01262308,
-0.010616983,
0.014036012,
0.008324301,
0.0063348664,
0.0013829403,
0.018421432,
0.029245023,
0.010923563,
-0.004205472,
0.018314796,
-0.002259358,
0.0044887243,
0.006191574,
0.009557284,
-0.017381728,
0.027538842,
0.034230273,
0.014142647,
0.0039622076,
-0.011723335,
0.0018178168,
-0.016795227,
-0.0025542742,
-0.017928239,
-0.007097983,
0.024139807,
-0.00911741,
0.009803881,
0.008264318,
0.041188296,
0.01379608,
-0.011563381,
-0.0050219065,
0.00172451,
-0.025019556,
0.004672006,
0.011563381,
0.013342875,
-0.0053751394,
-0.025699364,
0.01991434,
-0.020300899,
-0.0073112557,
0.0075845113,
-0.008197671,
-0.00601829,
0.010343728,
-0.0014004353,
0.013742762,
-0.022380307,
-0.0059183184,
-0.0013496164,
-0.039242182,
0.03308393,
0.017555011,
-0.007057994,
-0.03020475,
-0.026019273,
-0.004432074,
-0.029165046,
0.016022114,
-0.0001865095,
0.025206171,
0.030364705,
0.019767717,
0.0014812457,
-0.017208444,
0.003380706,
-0.021180648,
0.028205318,
0.017208444,
-0.0053718067,
0.00878417,
-0.017714966,
-0.023206739,
0.04017525,
-2.5546126e-7,
-0.006554804,
-0.0122365225,
-0.004322105,
-0.020767432,
0.010730284,
0.010237091,
-0.017674977,
-0.02699233,
-0.017275091,
0.022540262,
-0.02549942,
-0.0071912897,
0.0062049036,
-0.007604506,
-0.03316391,
-0.027405545,
-0.021607194,
-0.0115033975,
0.043294363,
0.020367546,
-0.011330114,
0.03519,
0.0075711817,
0.022500273,
0.005738369,
-0.02373992,
-0.0010480356,
-0.024872933,
-0.0019011265,
-0.0030241406,
0.03457684,
0.0024842941,
0.0019544447,
0.026752397,
0.011456745,
-0.020660795,
-0.0136894435,
0.017661648,
0.03633634,
-0.0263925,
0.005974969,
0.021300614,
0.026579114,
-0.022646898,
0.031297773,
-0.010916898,
0.014835784,
-0.016435329,
-0.013809409,
-0.0077577955,
0.010930227,
0.00212273,
0.003682287,
-0.02407316,
-0.00065939594,
0.012503114,
0.0069713523,
-0.018288136,
0.03345716,
0.025366126,
0.020300899,
0.0103037385,
-0.007677818,
0.00088224927,
0.00008107071,
0.023993181,
-0.04257457,
-0.033057272,
0.008990779,
-0.013049625,
-0.022513602,
-0.013109608,
0.018927954,
-0.012956318,
0.00358898,
-0.009030767,
-0.016661933,
-0.023353364,
-0.025965955,
-0.0322575,
0.016488647,
-0.010590324,
-0.012556432,
-0.00039030577,
-0.00593498,
-0.022073727,
-0.035376612,
0.00051610335,
-0.024499705,
-0.039775364,
-0.01129679,
0.0043420997,
0.016275374,
-0.008410944,
0.023340033,
-0.013536153,
-0.013256233,
0.014382579,
-0.016928522,
-0.013376199,
0.0037855909,
-0.05550423,
0.033910364,
0.002251027,
0.016875204,
-0.00981721,
-0.027405545,
0.020447522,
0.007737801,
-0.0037555995,
0.020314228,
0.00793108,
-0.024406398,
0.018381443,
0.02084741,
0.010197102,
-0.0049285996,
-0.0035156675,
-0.013062955,
-0.047079954,
-0.004672006,
-0.02318008,
0.01758167,
-0.024006512,
-0.0044254092,
0.011183489,
-0.02371326,
-0.0025326137,
0.012263182,
-0.022860171,
0.012143216,
0.017701637,
0.02605926,
0.03519,
0.012543103,
-0.008064375,
0.010170443,
-0.002069412,
0.0036522956,
0.0003424027,
-0.00059316476,
0.021313943,
-0.009110744,
0.018501408,
-0.007911085,
-0.015502261,
-0.017155126,
0.011769989,
-0.021793807,
0.03255075,
0.025606057,
-0.01039038,
-0.012409807,
-0.00512521,
0.008990779,
0.013649454,
0.004235463,
-0.029778205,
-0.020860739,
-0.0058516706,
0.018714681,
-0.008324301,
-0.008990779,
-0.025726022,
-0.0070846532,
0.014022682,
-0.0018911293,
0.005078557,
0.007277932,
-0.008131023,
-0.01586216,
-0.0051885257,
-0.016501978,
-0.022460284,
0.010450364,
-0.008250989,
0.04188143,
0.025952626,
0.03140441,
-0.014155977,
0.02640583,
0.039428797,
0.012163211,
0.0035756505,
-0.007977733,
0.0061082644,
-0.02669908,
0.011889955,
0.02699233,
-0.004628685,
-0.005415128,
-0.012389813,
0.012563096,
0.016621944,
-0.017061818,
-0.027805433,
0.006141588,
-0.040095273,
-0.03841575,
0.000616908,
-0.0035823153,
-0.0041354913,
-0.027485523,
0.0004188393,
0.021020694,
-0.009410659,
0.016395342,
-0.015942136,
0.032657385,
0.0061015994,
0.033110593,
0.011530057,
0.034363568,
-0.02433975,
-0.002449304,
-0.011383432,
0.0035223323,
0.02696567,
-0.0058916593,
0.010157114,
0.008604222,
-0.015129034,
0.0016661932,
0.0029608253,
-0.019127898,
-0.01232983,
-0.00020004732,
-0.017221773,
0.0033840383,
0.00374227,
0.005665057,
-0.04337434,
-0.013549483,
0.000200568,
-0.012729716,
0.025899308,
-0.011749994,
-0.009770557,
0.035056707,
0.017115137,
0.049959138,
-0.017928239,
0.027325569,
0.01851474,
0.0069713523,
-0.021300614,
0.0009147401,
0.004512051,
-0.0040021962,
0.025885977,
0.016675262,
-0.00005178216,
-0.011876625,
-0.0029708224,
0.004148821,
-0.022660227,
-0.039615408,
0.017261762,
0.004338767,
-0.021927102,
-0.014995739,
-0.010870244,
-0.020834079,
0.015742194,
0.000046393066,
0.03465682,
0.0016920192,
-0.009284029,
-0.017941568,
0.006514815,
0.022660227,
0.025712693,
0.008077704,
0.0034390227,
-0.022660227,
-0.029564932,
-0.0008547571,
0.0062248977,
0.0010013821,
0.016595284,
0.011543387,
-0.0064315055,
0.019941,
0.021953762,
-0.010457029,
-0.021487227,
0.00029762374,
0.03233748,
-0.009124074,
-0.0064048464,
0.0067180907,
0.024646329,
0.023300046,
-0.0052285143,
0.005191858,
0.015488932,
-0.013422852,
-0.01851474,
0.0048519545,
0.02788541,
-0.0010880241,
-0.035403274,
-0.012396477,
0.009743898,
-0.011943273,
-0.009384,
0.03774927,
-0.037429363,
0.008497586,
-0.0064981533,
-0.0011271797,
0.004408747,
-0.00028616868,
0.024473045,
-0.0029808197,
0.033857044,
-0.032710705,
0.009024102,
0.013862727,
0.004815298,
-0.01906125,
0.018941285,
0.0068380567,
-0.02084741,
0.019181216,
-0.008131023,
-0.012863011,
-0.0023193408,
-0.016288705,
0.016861875,
0.015195682,
-0.01616874,
-0.013389529,
-0.012569762,
0.027325569,
0.00043570952,
0.004228798,
0.010730284,
-0.008177676,
0.017088477,
0.033590455,
-0.021233967,
0.023340033,
-0.032923978,
-0.0020727443,
0.0078777615,
-0.006708094,
-0.030284727,
-0.0021293948,
0.010537006,
0.0007114645,
-0.017141795,
0.03105784,
-0.0153956255,
-0.0275655,
0.008037716,
0.00089307956,
-0.0038655682,
-0.0072046192,
0.007297926,
0.016008785,
0.011363437,
-0.008197671,
0.021273954,
0.014622511,
-0.01819483,
-0.0439875,
0.006831392,
-0.0070846532,
0.014622511,
0.0036023096,
-0.025699364,
-0.011849966,
-0.007897756,
-0.035989773,
-0.014915762,
0.007557852,
-0.0075778468,
0.008857483,
0.020167602,
-0.0019960995,
-0.015355636,
-0.0029641576,
0.0357765,
0.012269847,
0.014542534,
0.0044220765,
-0.007011341,
0.0008339297,
0.016222056,
-0.055131,
0.0044953893,
0.024579681,
0.0073779034,
-0.0013996023,
0.027298909,
-0.0004373757,
0.031750977,
0.0018178168,
-0.015288989,
0.018461421,
0.03105784,
0.023046784,
-0.0136894435,
-0.01702183,
0.03377707,
0.012982978,
-0.019687738,
0.00018265643,
-0.005718375,
0.0011738332,
0.019927671,
-0.011116841,
-0.031137818,
0.0027442202,
-0.0058150142,
-0.0058949916,
0.013482835,
0.0022743538,
0.001224652,
-0.0054217926,
-0.016008785,
0.005005244,
-0.0104303695,
0.0032674049,
-0.020340886,
-0.0008143519,
0.0049485937,
0.009317352,
-0.011316784,
0.012216529,
-0.00594831,
0.0023759915,
0.0012396477,
-0.013162926,
-0.011803312,
0.020887397,
0.020127613,
0.009057426,
-0.013969364,
0.0028758494,
-0.026165897,
-0.009050761,
-0.016088761,
0.008270983,
0.008144353,
0.03052466,
0.010157114,
-0.016395342,
-0.0013421186,
-0.009883858,
-0.015169023,
-0.014915762,
0.016461989,
0.19695736,
-0.022073727,
0.00835096,
-0.0023493324,
-0.011610034,
-0.010776938,
0.0076245,
0.0004407081,
-0.004345432,
0.0062982105,
0.020647466,
0.0056317328,
-0.010870244,
0.0011763324,
0.012209863,
-0.037615977,
-0.0404685,
0.003708946,
-0.0043054433,
-0.0043620938,
0.01938116,
-0.0020494177,
-0.008810829,
-0.016008785,
0.020687455,
-0.0001873426,
-0.03132443,
0.019714398,
0.012769705,
-0.0014704155,
-0.023486659,
-0.008097699,
0.0042387955,
-0.006771409,
0.008770841,
0.016875204,
0.007057994,
0.0038155825,
0.007297926,
-0.0012796364,
0.002595929,
0.02172716,
-0.002647581,
-0.017728295,
-0.007564517,
-0.009384,
-0.0023076776,
0.007824443,
-0.017928239,
-0.011130171,
-0.02492625,
-0.017115137,
-0.028152,
0.028658522,
0.004458733,
-0.003562321,
0.016515307,
0.0025642712,
-0.006554804,
0.0006518981,
-0.003354047,
0.018088194,
-0.048332933,
0.010750279,
-0.0048752814,
0.030418023,
-0.01791491,
0.017475035,
0.013982694,
-0.017261762,
-0.011610034,
-0.017141795,
-0.0039355485,
0.008470926,
-0.014622511,
-0.007097983,
0.02577934,
0.010357057,
0.031457726,
0.0037989204,
0.009757227,
-0.00505523,
-0.02844525,
-0.010603653,
0.0030158097,
-0.026165897,
0.022500273,
0.011909949,
-0.042547908,
0.025406113,
0.00734458,
-0.006011625,
-0.008024386,
-0.022713546,
0.011383432,
0.0045687016,
0.0038922273,
0.002630919,
-0.011036864,
-0.022766864,
-0.029218365,
0.044147454,
-0.0063615255,
-0.003778926,
-0.017555011,
0.030364705,
0.011603369,
0.009437318,
-0.0015278992,
-0.009477307,
0.007157966,
0.0031174475,
0.009064091,
0.002915838,
0.017648319,
0.02905841,
0.026512466,
-0.029858181,
0.05345148,
0.0066681053,
-0.01350283,
-0.006068276,
-0.0033440497,
0.029431637,
-0.0076378295,
-0.008917466,
-0.008844153,
0.012103227,
-0.033590455,
-0.03545659,
0.023353364,
-0.005598409,
0.006011625,
-0.0012129886,
-0.012703056,
0.0044020824,
0.0011021867,
-0.021753818,
-0.01099021,
-0.00030491335,
-0.011490068,
0.005838341,
-0.006754747,
0.010876909,
0.00029137553,
-0.03519,
0.014342591,
0.013529489,
-0.018114852,
-0.004045517,
-0.011223477,
-0.014249284,
-0.03193759,
0.0076444945,
0.0077577955,
-0.02788541,
-0.020607477,
-0.038175818,
0.009197386,
0.007564517,
-0.007771125,
-0.0043054433,
0.0050152414,
-0.006658108,
0.010077137,
-0.014235955,
-0.16741909,
0.015342307,
0.016355352,
-0.01934117,
0.030098114,
0.02669908,
0.015555579,
0.023340033,
0.018408103,
0.0069047045,
0.027538842,
0.008297642,
-0.030098114,
-0.03553657,
0.013256233,
0.01931451,
-0.018927954,
0.03313725,
0.020060966,
0.00878417,
0.028765159,
-0.031777635,
0.017941568,
-0.008824159,
0.0041021677,
-0.008037716,
-0.010037147,
-0.008250989,
-0.02084741,
-0.027752114,
-0.016288705,
0.019874353,
0.008011057,
-0.022620238,
0.012383148,
0.00021129413,
0.020394204,
0.021580534,
0.00005482817,
0.0075711817,
0.040708434,
-0.000018145885,
-0.005105216,
-0.0074045626,
-0.032923978,
0.01496908,
0.0035356618,
-0.017834932,
0.025486091,
0.02050084,
-0.0039388807,
0.006468162,
0.00019088326,
0.013636125,
0.012876341,
0.0006956357,
-0.004155486,
0.010377051,
-0.001569554,
0.0035556562,
-0.008664205,
-0.03814916,
0.02227367,
-0.008510915,
-0.019167887,
-0.038495727,
-0.014249284,
-0.009950506,
-0.008877478,
0.018128183,
-0.014395909,
0.0047986363,
-0.0035423266,
-0.017155126,
0.012169875,
0.015768852,
-0.011536722,
0.01406267,
-0.009877193,
-0.040041953,
-0.010943557,
0.018434761,
-0.0252195,
-0.021833796,
-0.018141512,
0.0089641195,
-0.009197386,
0.007897756,
-0.012449795,
0.007104648,
0.026165897,
-0.014155977,
-0.0009372337,
-0.008577563,
0.024139807,
-0.002302679,
0.013942705,
-0.001846142,
0.0028175327,
0.010290409,
0.0069646877,
0.0033107258,
-0.012163211,
0.013109608,
0.023886546,
-0.0021427243,
-0.01760833,
0.0028775157,
0.05257173,
0.0048752814,
-0.018994601,
-0.0076711536,
0.010676966,
0.038922273,
0.0070779887,
0.026805716,
-0.022646898,
-0.031804297,
0.017741624,
-0.02343334,
0.047399864,
0.003915554,
-0.0061182613,
0.010463693,
-0.015022398,
-0.029751545,
-0.12721719,
-0.011563381,
0.0016570291,
0.029751545,
-0.014102659,
-0.0014262614,
-0.0081176935,
0.0028625198,
-0.027152285,
0.034710135,
-0.014742478,
-0.038602363,
-0.021847125,
-0.007337915,
0.0099705,
0.019101238,
-0.0033090597,
-0.00910408,
-0.018501408,
0.020567488,
0.0049885823,
-0.024086488,
0.0038489064,
-0.008064375,
0.010903568,
-0.0096839145,
-0.022087056,
0.016875204,
0.008997443,
0.016262045,
0.0030041463,
-0.022127045,
0.0099705,
-0.01334954,
-0.027938727,
-0.01644866,
-0.0018977941,
-0.01189662,
0.0037589318,
-0.010183773,
-0.011456745,
0.00925737,
0.013916045,
0.005658392,
0.013916045,
-0.004572034,
0.024832943,
-0.0005681719,
-0.013929375,
-0.013496165,
-0.047346547,
-0.029858181,
-0.046840023,
-0.0041254945,
0.010377051,
-0.019287853,
0.013836068,
0.011043528,
-0.0077311364,
-0.018887967,
0.002570936,
0.010443699,
-0.012549767,
-0.0009255703,
-0.0064581647,
-0.012936324,
-0.021327272,
-0.04014859,
0.002294348,
-0.029804863,
-0.0057017133,
0.008177676,
-0.014155977,
0.009370671,
-0.03718943,
0.02699233,
-0.03665625,
-0.02168717,
0.02785875,
-0.021207307,
-0.00036135566,
-0.015355636,
0.03633634,
-0.04931932,
0.046760045,
0.014489216,
0.0035556562,
0.00066856004,
0.014502546,
-0.008430937,
-0.030018136,
0.010903568,
-0.023113431,
-0.014222625,
-0.011836637,
0.009370671,
-0.02315342,
0.006951358,
0.015049057,
0.015022398,
-0.008157682,
0.0063415314,
-0.05875664,
0.006664773,
-0.013616131,
0.008430937,
0.006071608,
-0.018688023,
0.007597841,
0.008131023,
-0.00036927007,
0.03204423,
-0.026765727,
0.01582217,
-0.011909949,
-0.020727443,
-0.01071029,
-0.020420864,
0.037695955,
0.013582807,
0.023486659,
0.026219215,
-0.026952341,
0.0055817473,
0.011376767,
0.020647466,
-0.015902149,
0.029191704,
-0.006588128,
0.02844525,
-0.011243472,
-0.008184341,
0.01879466,
-0.03345716,
-0.02465966,
-0.0038855625,
-0.011483404,
-0.014702489,
0.008884142,
0.02523283,
0.013456176,
0.02903175,
-0.028525228,
-0.024326421,
0.025126193,
0.025126193,
0.005848338,
0.018141512,
-0.027072307,
0.021153988,
-0.0027475525,
0.0044987216,
0.036176387,
0.009350676,
-0.0032190853,
-0.02023425,
-0.020327557,
0.005768361,
0.007737801,
0.000004432334,
0.009010773,
-0.015115704,
0.034763455,
0.025472762,
0.036043093,
0.0018261478,
0.0056617246,
-0.025179511,
-0.020460851,
-0.0001269431,
-0.0010172109,
-0.055610865,
-0.019794375,
0.01379608,
0.0029374985,
0.012563096,
-0.0070046764,
0.0088508185,
-0.0053518126,
0.0050652274,
0.0016570291,
0.0004415412,
-0.010976881,
-0.0070913183,
-0.0005760863,
0.015222341,
0.010230426,
0.0011630028,
0.005521764,
0.0025842655,
-0.011190154,
0.003918886,
0.0170085,
0.033110593,
0.01784826,
0.0072845966,
0.011210148,
0.035403274,
-0.011256801,
0.0025892642,
-0.00579502,
0.0439875,
-0.014982409,
0.022713546,
-0.00025596892,
-0.028898455,
0.013122938,
0.030498,
0.001984436,
-0.036442976,
0.0004319606,
0.0063881846,
0.009024102,
0.014115988,
0.0015312316,
-0.0058883266,
-0.016461989,
-0.008690864,
-0.004865284,
-0.022766864,
-0.0025742685,
0.013049625,
0.03345716,
0.022620238,
-0.0112767955,
-0.011096846,
0.033243887,
0.020447522,
0.031431068,
-0.00032261666,
0.009150733,
-0.0054284576,
0.007957739,
0.018688023,
-0.013316216,
-0.02291349,
0.010950222,
-0.0081176935,
0.02461967,
-0.0031174475,
-0.028951773,
0.07704477,
0.02347333,
-0.027752114,
0.024366409,
-0.034230273,
0.029644908,
0.012683063,
0.0070846532,
0.0007885259,
-0.034843434,
0.00865754,
0.008097699,
0.0049952473,
-0.026045932,
-0.00045945277,
0.005768361,
-0.014142647,
0.003079125,
-0.02260691,
-0.023899876,
0.010630312,
-0.020100955,
0.020100955,
-0.001682022,
-0.025566068,
-0.0017961563,
0.016661933,
-0.026979,
0.016861875,
-0.016075432,
-0.011196818,
-0.019767717,
-0.033670433,
-0.023300046,
-0.0059616393,
0.0037256079,
-0.012263182,
-0.014342591,
0.044174112,
-0.0066947644,
0.0069780173,
-0.01903459,
-0.024979569,
-0.045080524,
0.007631165,
0.016861875,
-0.018221488,
-0.012922995,
-0.0070513296
] |
Leukemia in donor cells (donor cell leukemia; DCL) has been reported as a rare but severe complication of allogeneic stem cell transplantation (SCT). However, the incidence, potential pathogenetic factors, therapeutic options and outcome of patients suffering from DCL and the leukemia risk of their donors are not well defined. A questionnaire survey was carried out within European Blood and Marrow Transplantation Group (EBMT) centers. Ninety-one EBMT centers participated in this survey, covering 10489 allogeneic SCT between 12/1982 and 09/2003. Fourteen cases of | [
-0.00075440813,
-0.018837942,
0.030763362,
-0.05115794,
-0.020355003,
0.040208716,
-0.011648391,
0.015368489,
-0.030314839,
0.016080847,
-0.009207902,
0.012631183,
-0.0005301469,
0.031000813,
-0.0074270037,
0.010210481,
0.030816128,
-0.010164309,
-0.014933158,
0.0077567995,
-0.027861157,
-0.0067212405,
0.0039773383,
0.009418971,
0.012868635,
0.014682514,
0.032346383,
-0.03010377,
0.010269844,
0.007156571,
0.006180375,
-0.004109257,
-0.019049011,
-0.013218219,
-0.023178056,
-0.008706612,
0.0260143,
-0.009867493,
0.015962122,
0.0011015183,
0.012156277,
0.02852075,
0.001614351,
-0.009122155,
0.0023679344,
0.00786893,
0.014207607,
-0.015276146,
0.010137926,
0.021423541,
0.03218808,
0.002090906,
-0.016938318,
0.015513599,
-0.01581701,
-0.0024635752,
-0.0055735507,
-0.0045379917,
0.007163167,
-0.01153626,
0.00076388975,
0.004396179,
-0.0051052403,
-0.002085959,
-0.0006752571,
0.006813583,
-0.00020663773,
0.008218514,
0.007981061,
0.013158856,
0.02234697,
0.018719215,
0.029206725,
-0.012697142,
0.0002370408,
-0.00058827345,
-0.0086406525,
-0.001649804,
-0.007631477,
-0.0013513387,
0.017162578,
-0.023006562,
-0.025024913,
0.029655246,
0.022966987,
0.0018320162,
-0.007149975,
-0.008884701,
-0.022795493,
-0.0025592162,
0.0025493223,
0.012512457,
0.0033111507,
0.016212767,
-0.016502986,
0.011819885,
0.013930579,
0.031291034,
0.013086301,
-0.03643585,
0.0017083427,
0.015777435,
-0.014642938,
-0.019946055,
-0.048255734,
0.0015483918,
0.020170316,
-0.0014766611,
0.0010339101,
0.001488204,
-0.024827035,
0.046435263,
0.015157419,
-0.034905598,
0.03501113,
-0.017874938,
0.013693126,
0.002001861,
-0.01602808,
-0.009036408,
0.02530194,
-0.0037135019,
0.017980471,
-0.038045254,
0.013376522,
0.026621124,
-0.02918034,
0.0044852244,
-0.017571526,
-0.00069628155,
-0.0068993303,
0.00050582446,
-0.011839673,
0.0064705955,
-0.01746599,
-0.0049700243,
-0.017505566,
0.0008389183,
-0.016898742,
-0.018297076,
-0.013297371,
0.022294203,
0.0067047505,
0.005886857,
-0.00909577,
0.01192542,
0.023969566,
-0.0011559346,
0.009564081,
-0.007657861,
0.0077765873,
-0.011701158,
0.013956962,
-0.017861746,
-0.005243755,
0.012472881,
0.022030367,
0.023534235,
-0.0091419425,
-0.0061638854,
-0.025447052,
-0.02241293,
0.01911497,
-0.0024718202,
0.006615706,
0.030499524,
-0.005840685,
0.009907069,
-0.0117473295,
-0.014603362,
-0.0009324979,
0.036277547,
-0.0059033465,
0.009254073,
0.0011031673,
0.001493151,
-0.018481761,
0.01919412,
-0.05044558,
-0.025684504,
-0.026344096,
0.032821286,
0.0109624155,
0.012228832,
-0.008765975,
-0.012710334,
0.0074401954,
-0.012209044,
0.0024305957,
-0.0049535343,
0.0014667673,
0.012400325,
-0.0023926692,
-0.035749875,
-0.6361631,
-0.029233107,
-0.007809567,
0.017215345,
0.011272424,
0.004155428,
0.02206994,
-0.0054284404,
-0.050551116,
0.008667036,
0.007948081,
0.004917257,
0.018310267,
-0.01221564,
0.012024358,
-0.024813844,
-0.010724963,
-0.004432457,
0.021885255,
-0.0015525141,
0.008165746,
-0.0024569794,
-0.018930284,
0.017268114,
-0.009636636,
-0.0035024325,
0.021766528,
-0.0021403753,
-0.010619428,
0.007248914,
-0.012941191,
0.008264685,
-0.009874089,
0.010223673,
0.04770168,
0.020869484,
-0.0058340896,
0.014392293,
0.01444506,
0.022465697,
0.02457639,
-0.01139115,
0.013356734,
0.008686824,
-0.018785175,
0.019563492,
0.017901322,
0.006971885,
-0.0005577673,
0.019787753,
0.010804114,
0.014695705,
-0.02801946,
0.018086007,
0.004907363,
-0.0017132896,
0.032531068,
-0.009557485,
0.0028065632,
0.0030918366,
-0.011259232,
0.004650122,
-0.0163183,
-0.01045453,
0.016437028,
-0.0115296645,
-0.029523328,
0.0051580076,
0.013416097,
-0.0025856,
0.020249467,
0.011938611,
0.006496979,
0.0072621056,
0.017400032,
0.012195853,
-0.0013793713,
-0.01207053,
-0.014497828,
-0.004749061,
-0.017663868,
-0.012083721,
0.009577272,
0.007796375,
0.038098022,
0.004181812,
0.008601077,
0.02767647,
0.0012169469,
0.0066387914,
-0.0016522774,
0.010593045,
-0.012400325,
-0.03886315,
-0.00866044,
0.019774562,
-0.012552031,
-0.013759085,
0.014484636,
-0.026871769,
-0.025394283,
-0.008205322,
0.020513305,
-0.0042180894,
0.023098905,
0.007182955,
-0.047121238,
-0.016476603,
0.040129565,
-0.053136714,
0.0011344979,
-0.0063947425,
-0.0125982035,
-0.009254073,
0.024391705,
-0.012011167,
-0.0024701713,
0.0026119836,
0.0014939754,
-0.035881795,
0.011443918,
0.008390008,
0.020275852,
-0.009557485,
-0.00084592646,
-0.0002287959,
0.022228243,
-0.017043851,
0.009353012,
-0.0059890933,
-0.008845126,
-0.014458252,
0.03369195,
-0.031053582,
0.020091167,
-0.024563199,
0.020829909,
-0.012921403,
0.0024718202,
-0.0041125547,
-0.026185794,
-0.002168408,
0.0169647,
0.00216511,
-0.012519052,
0.0072555095,
-0.013877811,
-0.025170023,
-0.00091271015,
-0.022874644,
-0.00815915,
-0.011885844,
-0.015368489,
0.007717224,
-0.014919966,
-0.007143379,
-0.01688555,
-0.036462232,
0.008205322,
-0.03799249,
-0.005850579,
0.020988211,
0.0050293873,
0.023521043,
0.0044588405,
-0.006668473,
-0.0039179754,
-0.014036113,
-0.015579558,
-0.031211883,
0.014524211,
-0.02392999,
0.007835951,
0.020790333,
0.003680522,
0.0032517875,
-0.0030753468,
-0.008000849,
0.0027801795,
0.0040202118,
-0.013257795,
-0.01997244,
0.0029104487,
-0.011589028,
0.0023596897,
0.013825044,
0.031238267,
0.019088587,
0.006905926,
0.014247183,
-0.009827917,
0.010553469,
-0.024879802,
-0.0009349714,
-0.0072159343,
0.015183803,
-0.011760522,
0.017043851,
0.017927704,
0.032240845,
0.033375345,
0.0036475426,
0.04870426,
0.003838824,
0.022162285,
-0.012802676,
-0.0015978611,
-0.012802676,
0.027544552,
0.03543327,
-0.0007164816,
-0.009010023,
0.014524211,
-0.0007964571,
0.007565518,
-0.0011419182,
-0.008587885,
-0.0012309632,
-0.0024157548,
-0.009056196,
-0.0221359,
-0.0022986773,
0.014656129,
-0.0044390527,
0.014075689,
0.0064442116,
0.0065464485,
-0.001281257,
0.0051580076,
-0.0073346607,
-0.019088587,
0.013435884,
0.024761075,
0.0040202118,
-0.0093266275,
0.013996538,
0.025776846,
0.008409795,
0.033823866,
-0.008970449,
-0.016423836,
0.019484341,
0.0088583175,
0.022465697,
0.0005194285,
-0.007908505,
0.02336274,
0.0021453223,
-0.02134439,
0.01659533,
-0.0007737836,
0.021027787,
-0.019748177,
0.0028263507,
-0.002006808,
-0.02184568,
-0.0014403836,
0.039074216,
0.017294496,
-0.0029879508,
0.014735281,
-0.0030638038,
-0.0043038363,
-0.012749909,
-0.005527379,
0.0062364405,
0.010006008,
-0.019840522,
-0.014286758,
0.00675422,
-0.026964113,
-0.015513599,
0.020922251,
-0.04923193,
0.0063980403,
0.027386252,
0.023982758,
0.012525648,
0.01924689,
0.008172343,
-0.0015096407,
-0.027570937,
0.01703066,
0.039338056,
-0.02013074,
-0.00772382,
-0.017452799,
0.000045836478,
0.010553469,
0.02063203,
0.00963004,
0.017808978,
0.009385991,
0.014906774,
0.0032831181,
-0.020486921,
0.017294496,
-0.006892734,
0.020895869,
-0.015948929,
0.0011287264,
-0.011622007,
-0.035908177,
-0.01968222,
0.05799131,
0.007697436,
0.009992816,
-0.022821875,
0.0020002122,
-0.018283885,
-0.020051591,
-0.035670724,
-0.01059964,
-0.005563657,
-0.010071967,
0.012195853,
0.019589877,
0.037227362,
0.015909353,
-0.020500112,
-0.016911933,
-0.021515884,
0.0013323755,
-0.020341812,
0.041580666,
0.024035525,
-0.018363036,
0.013732701,
-0.016845975,
0.003289714,
0.010210481,
-0.025592161,
0.029127574,
-0.0030703999,
0.005065665,
0.0042807506,
0.006035265,
0.020856293,
0.0093596075,
0.038995065,
-0.01817835,
-0.0057450444,
-0.013284178,
-0.006483787,
-0.0035519018,
-0.02336274,
0.026924537,
0.048176583,
0.008383412,
-0.0063056974,
0.0057813223,
0.014431869,
0.0023877223,
0.015276146,
-0.018600488,
0.026357288,
0.012611395,
0.024088291,
0.0064639994,
-0.007888718,
0.00015912652,
-0.0021453223,
0.0014915019,
0.0039278693,
0.035749875,
0.005382269,
0.013983346,
0.0023003265,
0.014075689,
-0.028072227,
0.008970449,
0.012631183,
-0.006658579,
-0.011371362,
0.04857234,
-0.018508146,
-0.016793206,
-0.012769697,
0.0010817306,
0.021225663,
-0.0078029707,
-0.00466991,
0.005718661,
0.010513893,
0.012842252,
-0.018112391,
0.017426414,
0.01103497,
-0.02528875,
0.0004926326,
-0.027412634,
-0.009062791,
-0.008996832,
-0.01703066,
-0.0047853384,
0.018112391,
-0.03155487,
-0.0082910685,
0.006892734,
-0.016911933,
0.035776258,
-0.008587885,
0.010546872,
0.018376227,
-0.01997244,
0.0076710526,
0.013666742,
-0.028626284,
-0.00018664387,
0.01480124,
0.010645811,
-0.009181518,
-0.028916504,
0.01081071,
-0.008957257,
0.00018788059,
-0.022267818,
0.0063056974,
0.01106795,
0.004422563,
0.023230823,
0.009992816,
-0.021581843,
-0.009201306,
-0.0034265793,
-0.039206136,
-0.037543964,
0.015500407,
-0.021779722,
-0.01911497,
-0.00303742,
0.007934889,
0.0146693215,
-0.013891003,
0.0266607,
-0.02939141,
-0.0013026937,
0.0025130447,
0.023995949,
0.016542561,
0.0034991344,
-0.0053723752,
0.027702855,
0.0055108895,
0.004003722,
-0.030525908,
0.022399737,
0.012723526,
-0.010507297,
0.001772653,
0.018363036,
-0.024444472,
-0.019946055,
-0.025552586,
0.018917093,
0.027834773,
-0.013297371,
0.0042708567,
-0.030367605,
-0.0020249467,
0.020856293,
0.023626577,
-0.002255804,
-0.02435213,
-0.006401338,
0.028705435,
-0.0018369631,
-0.022940602,
0.0026004405,
-0.03989211,
-0.008462562,
0.016278725,
0.00060847343,
-0.009471738,
-0.0058901547,
0.012888423,
-0.0021519181,
-0.0064442116,
0.0029483752,
-0.028863737,
-0.0014618203,
-0.0266607,
0.05260904,
0.020869484,
0.034747295,
-0.005273436,
0.046118658,
0.012914808,
-0.005197583,
0.008363624,
-0.012657566,
0.017703444,
-0.0045544812,
0.013891003,
-0.013224815,
0.0104941055,
0.0093596075,
-0.012248619,
0.020671606,
0.01918093,
-0.008383412,
-0.014273566,
0.0058901547,
-0.036910757,
-0.03168679,
0.000762653,
0.0024388407,
0.0141680315,
-0.02960248,
0.017782595,
0.017057044,
-0.00034195711,
-0.014827623,
0.0037365875,
0.029839933,
0.00045346934,
0.01602808,
0.004874383,
0.0017940897,
-0.008310856,
-0.023217632,
-0.011813289,
-0.018059622,
-0.009062791,
0.00008796275,
0.0038454202,
0.015645517,
-0.027359867,
-0.012637779,
0.016450219,
-0.031211883,
-0.028494366,
0.0051283264,
-0.02551301,
0.004102661,
-0.00998622,
-0.016173191,
-0.029470561,
-0.017927704,
0.009049599,
-0.009300244,
0.009827917,
-0.0015203591,
-0.008897893,
0.012604799,
-0.000764302,
-0.006421126,
-0.029233107,
0.015777435,
0.017993664,
-0.0260143,
-0.021674186,
0.0072884895,
0.00024466732,
0.007710628,
0.016489794,
0.031396568,
-0.025420668,
-0.006991673,
0.014405484,
0.02436532,
-0.0163183,
-0.0072818934,
0.013891003,
0.012063934,
0.0046798037,
-0.021476308,
-0.025460243,
-0.007921698,
0.0031000813,
0.005860473,
0.009201306,
0.009992816,
0.0039905305,
-0.008587885,
0.028204145,
-0.033955786,
-0.0043664975,
-0.005857175,
-0.00008708673,
-0.019352423,
-0.034404308,
-0.0505775,
0.007961273,
-0.00740062,
0.033876635,
-0.0049634282,
-0.007651265,
0.0047655506,
0.006031967,
0.0010602938,
-0.017716635,
-0.0123475585,
0.04031425,
0.0067937956,
0.014788048,
0.022584423,
0.0038454202,
-0.010513893,
-0.005052473,
0.0023662855,
-0.0054218443,
-0.04456202,
-0.028969271,
0.03363918,
0.035195816,
0.0038157385,
0.03688437,
-0.034536228,
-0.018455379,
0.00069999177,
-0.033665564,
0.0033441305,
-0.039338056,
0.0029335346,
0.011635199,
0.019985631,
0.013970154,
-0.014022921,
0.013251199,
0.015685093,
0.0221359,
0.0002848612,
0.014049305,
0.014774856,
0.009036408,
-0.027544552,
-0.00016479488,
-0.0030918366,
-0.029734397,
0.0009481632,
0.0026762937,
-0.003944359,
-0.022003982,
-0.016041271,
-0.00014943877,
-0.0076644565,
-0.020829909,
0.01459017,
0.00079398364,
0.0336128,
0.00801404,
-0.0041686203,
0.023098905,
-0.039206136,
-0.0006439265,
-0.0014436815,
-0.00057178363,
0.0034199834,
-0.001439559,
0.009273861,
-0.022083133,
-0.019932864,
-0.010533681,
0.0002141612,
0.018389419,
-0.013356734,
0.0127828885,
-0.0253679,
-0.0071038036,
-0.008719804,
0.013534823,
0.0017957387,
0.0011147101,
0.0034100895,
-0.010665599,
-0.0026070366,
0.030816128,
-0.0032781712,
0.01394377,
-0.004788636,
-0.019880097,
-0.020671606,
0.010006008,
-0.0057813223,
0.021252047,
-0.0007585306,
0.013811852,
-0.023903606,
-0.0021453223,
-0.061685026,
-0.014181224,
0.013930579,
0.013026938,
0.031924244,
0.025987916,
0.00011821122,
0.017954089,
-0.010071967,
0.0428207,
-0.0072093382,
-0.004584163,
0.03369195,
0.0015211835,
0.023877222,
0.0053064157,
-0.04809743,
-0.018389419,
0.011951803,
0.00963004,
0.0053492896,
0.013046726,
-0.0057351505,
0.017268114,
0.00056724896,
0.0029219915,
-0.015394872,
0.0067608156,
-0.024945762,
-0.027597321,
0.009887281,
0.0055207834,
0.0040301057,
-0.011404342,
0.007466579,
0.0000149309935,
-0.0013397958,
0.0019391999,
-0.01077773,
-0.027597321,
0.007064228,
-0.022623999,
-0.008765975,
0.004890873,
0.0043203263,
0.023718921,
0.004676506,
0.018415803,
0.0038718039,
0.0025740569,
0.011549452,
-0.03060506,
-0.00815915,
-0.0030918366,
-0.0024355426,
-0.0072093382,
-0.0044786283,
-0.020856293,
0.009511313,
-0.005385567,
-0.017400032,
-0.029628864,
0.028758202,
-0.0034793466,
-0.029919084,
-0.0008995183,
0.011615411,
-0.04086831,
-0.014379101,
-0.0069520976,
0.018626872,
-0.025816422,
-0.012980767,
-0.026607933,
-0.012268407,
-0.02435213,
0.005563657,
-0.023296783,
-0.015408064,
-0.0015104652,
0.17930344,
-0.020289043,
-0.014880391,
0.008165746,
-0.0023432,
-0.017571526,
0.023613386,
0.0063914442,
-0.019589877,
0.012829061,
0.028309679,
0.0055570607,
0.011668179,
0.0036277547,
0.020420961,
0.026357288,
-0.02530194,
-0.036172014,
-0.008475754,
-0.01774302,
-0.023600195,
0.012162873,
-0.00093084894,
-0.011958399,
0.028969271,
0.004406073,
-0.00001457028,
0.020777142,
0.02939141,
0.008475754,
-0.011879249,
0.008455967,
-0.0040004244,
-0.012162873,
0.020460537,
-0.008119575,
-0.0022772406,
-0.03564434,
-0.011219656,
0.012901615,
-0.016714055,
-0.004165322,
-0.020209892,
0.0019161141,
0.0013818447,
0.026898153,
0.005032685,
0.0026631018,
-0.0020546285,
-0.031950627,
-0.033797484,
-0.0025559182,
0.0049271504,
0.023125289,
0.007624881,
-0.0019490938,
0.03564434,
0.014682514,
-0.008488947,
0.0107117705,
-0.00386191,
0.0130994925,
-0.003703608,
0.025631737,
-0.015315722,
0.020236276,
-0.015671901,
-0.011674775,
0.02047373,
-0.01509146,
0.008416391,
-0.021067362,
-0.0045709712,
-0.004343412,
0.0036079672,
-0.023415508,
0.010329207,
0.012829061,
0.0030621549,
-0.0066387914,
0.004079575,
-0.022017173,
-0.016991084,
-0.0013208325,
-0.0013101142,
-0.026845386,
0.027043262,
0.015605941,
-0.020948635,
-0.002902204,
0.0058208974,
0.0141680315,
-0.014062497,
0.013158856,
0.010157714,
0.009854301,
0.019154545,
0.014524211,
0.0039938283,
-0.017334072,
-0.024259785,
0.09213178,
-0.0053987587,
0.024193827,
-0.02722795,
0.02586919,
-0.0071763587,
0.0053393957,
0.0036838201,
0.0002848612,
0.026383672,
-0.027359867,
0.0059956894,
-0.0011213061,
0.0016349631,
0.033164274,
0.015342105,
-0.0350639,
0.021463117,
-0.027439019,
-0.002244261,
-0.03276852,
0.012710334,
0.02889012,
-0.00028238774,
0.0004897469,
-0.012723526,
-0.008231706,
-0.01394377,
-0.0017710039,
-0.013640358,
-0.02155546,
-0.006820179,
0.008244897,
0.0031000813,
0.011628604,
0.0076710526,
-0.024391705,
-0.019273272,
-0.00038544895,
0.0005532326,
-0.013627166,
0.007941485,
-0.01817835,
0.006025371,
-0.018297076,
0.013640358,
-0.0080734035,
-0.031027198,
-0.026330905,
-0.020091167,
-0.010724963,
-0.029734397,
-0.009174922,
0.008211918,
-0.023521043,
-0.009702595,
-0.023824455,
-0.0015376734,
0.019853713,
-0.019154545,
0.027175182,
0.009385991,
-0.015065077,
0.0070774197,
-0.015619134,
-0.1654784,
0.0035914774,
0.0037497794,
-0.004996408,
0.026541974,
0.0003658673,
-0.0067146444,
-0.006243036,
-0.019589877,
-0.0038849956,
0.025486628,
0.013059918,
-0.045802053,
-0.012617991,
-0.0056559998,
-0.020368194,
-0.0078227585,
0.019853713,
0.030314839,
0.0061539914,
0.02069799,
-0.0071697626,
0.014656129,
-0.027861157,
0.019352423,
-0.0056494037,
0.010203885,
-0.011377959,
-0.018653255,
-0.01171435,
-0.008812146,
0.008330644,
-0.0003289714,
-0.013270987,
-0.021568652,
-0.005382269,
0.0021090447,
-0.005197583,
-0.00029413673,
0.016714055,
0.018059622,
0.01961626,
0.0028956078,
0.014022921,
-0.009075983,
0.06332081,
0.0141680315,
-0.026924537,
0.017808978,
0.0033622691,
0.017360456,
0.009959836,
0.013468864,
0.02257123,
-0.009564081,
0.02334955,
0.015790628,
-0.0063848486,
0.0019474447,
0.010217077,
0.0052767345,
-0.04260963,
-0.0033968978,
-0.0059099426,
-0.0049271504,
-0.03400855,
-0.008732995,
0.012406922,
-0.016054465,
0.0085417135,
-0.029496945,
0.00887151,
0.00040729792,
-0.018864324,
0.03255745,
0.021542268,
-0.0096432315,
0.026779426,
-0.0020529795,
-0.020091167,
-0.009748766,
0.03276852,
-0.0061243097,
-0.01924689,
-0.02069799,
0.023217632,
0.011114121,
0.024391705,
-0.0005585918,
-0.031370185,
0.024985338,
-0.026462823,
0.021436732,
-0.010837093,
-0.013613975,
0.026502399,
-0.011793501,
-0.01581701,
-0.014840815,
-0.02751817,
0.03369195,
-0.029312259,
-0.020223085,
-0.005075559,
0.01214968,
0.0041257464,
0.000021642856,
-0.0077567995,
0.028256912,
-0.0034199834,
-0.0070840158,
-0.0022145794,
0.017162578,
-0.0049436404,
-0.0055570607,
0.002889012,
-0.0014189469,
-0.017347263,
-0.0096432315,
-0.01509146,
0.046092276,
-0.0026202283,
-0.014563787,
0.012993958,
0.0044588405,
0.01315226,
-0.11334425,
0.013218219,
-0.000402351,
0.0036541384,
0.013224815,
0.0015574611,
-0.010335803,
0.0326366,
-0.0040696813,
0.033243425,
-0.03485283,
-0.020869484,
-0.005563657,
0.023587001,
0.0403934,
-0.0012614693,
-0.005075559,
-0.030156536,
-0.02722795,
0.04477309,
0.0074138115,
0.010190693,
-0.015685093,
-0.020381385,
0.02414106,
-0.0031528487,
-0.023692537,
0.02097502,
0.022650382,
0.03807164,
0.009280456,
-0.011133909,
0.012479477,
-0.008528522,
-0.016938318,
0.00786893,
-0.03400855,
-0.036330316,
0.02608026,
-0.024589581,
0.0022755917,
0.030024618,
-0.009102367,
-0.010586448,
0.00012903265,
-0.021806104,
-0.024444472,
0.008686824,
0.012921403,
-0.017281305,
-0.01059964,
-0.0339294,
-0.01709662,
0.0067410283,
0.022399737,
-0.011338383,
-0.0041884077,
0.0273071,
-0.042979002,
-0.0053360974,
-0.0038652078,
-0.0045247995,
-0.004900767,
-0.002907151,
0.036224782,
-0.0466991,
-0.010837093,
-0.014352717,
0.027570937,
-0.023666153,
-0.009023216,
-0.003776163,
-0.031871475,
-0.020223085,
-0.00052767346,
-0.019352423,
-0.0007956326,
-0.003052261,
0.00063650607,
-0.0035947752,
-0.0201967,
-0.009491526,
0.019998822,
-0.006750922,
0.043058153,
0.013013746,
-0.020961827,
-0.015078268,
0.0025146937,
-0.013561207,
-0.0031940732,
0.015355296,
-0.01386462,
-0.0038948895,
0.01013133,
-0.0019029223,
-0.00020756529,
-0.034720913,
0.033586413,
0.021357583,
-0.0046534203,
-0.0076908404,
-0.06036584,
0.0071763587,
-0.00801404,
-0.010151118,
0.0027752325,
-0.014972733,
0.0004650122,
-0.003759673,
0.020737566,
0.018626872,
-0.012110105,
0.01400973,
-0.042293027,
0.013613975,
-0.01045453,
-0.007677648,
0.0007733714,
-0.005319608,
0.024088291,
0.03255745,
-0.0035486037,
-0.03210893,
0.013416097,
0.030578675,
0.023481468,
0.013838235,
-0.00091848156,
0.03757035,
-0.011958399,
0.0046929955,
0.017914513,
-0.037543964,
-0.019946055,
-0.010447934,
-0.008897893,
-0.03772865,
0.01609404,
0.037834186,
0.027412634,
0.040155947,
-0.006186971,
-0.02105417,
0.018877517,
0.014827623,
-0.001166653,
0.014893583,
-0.023164863,
0.008000849,
0.0071103997,
-0.00400702,
0.03461538,
0.00045800404,
0.020236276,
-0.017954089,
-0.019009436,
0.005794514,
0.0187456,
-0.012868635,
-0.0011831428,
0.0014659427,
0.02379807,
0.0038058446,
0.012024358,
0.013125877,
-0.0048479997,
-0.0076842443,
-0.022017173,
0.002898906,
0.0013496897,
-0.01436591,
-0.01045453,
0.010652407,
-0.0041290447,
0.0053987587,
0.006744326,
0.0057483423,
-0.015355296,
0.009788342,
-0.014708897,
0.0023102202,
0.0014708897,
-0.010916244,
0.0039575505,
0.0050986446,
0.023507852,
0.008620865,
-0.021964407,
0.03313789,
-0.009010023,
0.010408359,
-0.016542561,
0.019629452,
-0.0050887507,
0.021146514,
0.01048751,
0.05403376,
-0.013825044,
-0.011859461,
0.0040762774,
0.0163183,
-0.019523917,
0.0019969142,
0.0027125713,
-0.036778837,
-0.031660404,
0.018046431,
-0.05060388,
-0.0416862,
-0.02184568,
0.011325191,
0.015408064,
-0.003914677,
0.010190693,
0.012077126,
-0.017492374,
-0.012116701,
-0.0059033465,
0.008726399,
-0.0048545958,
0.026185794,
0.009874089,
0.013310562,
0.017769402,
0.010428146,
0.025486628,
-0.015500407,
0.0020232978,
-0.019299656,
0.009148538,
0.011734138,
0.014616554,
0.0026350692,
-0.024602775,
-0.006820179,
0.011806693,
-0.022465697,
0.02451043,
-0.0051909876,
-0.0063947425,
0.05535294,
0.00386191,
-0.012235427,
0.012433305,
-0.024813844,
0.020513305,
0.029655246,
0.025935149,
0.019537108,
-0.017439608,
0.022584423,
-0.014220799,
0.018270692,
-0.046540797,
-0.037596732,
0.008831934,
0.009966432,
-0.0019820733,
-0.0017907917,
-0.0058934526,
0.0029269385,
-0.01092284,
0.0012326122,
0.019603068,
0.008258089,
-0.000047485457,
-0.003446367,
-0.0112790195,
-0.0144186765,
-0.025381092,
0.010691983,
-0.006351869,
-0.027359867,
-0.019866904,
0.0029483752,
0.0030126856,
-0.021502692,
-0.06274037,
0.01832346,
-0.0062958035,
-0.02184568,
0.028151378,
-0.018138774,
-0.016423836,
-0.023745304,
-0.041079376,
-0.042662397,
-0.026133027,
-0.0067608156
] |
BACKGROUND Since 2004, several reported transfusion transmissions of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom have reawakened concerns about the possible risk of similar transmissions of nonvariant or classic forms of CJD. STUDY DESIGN AND METHODS Patients with a CJD diagnosis and a history of donating blood were reported to the study coordinator. Through review of blood distribution and hospital records, the recipients of blood components from these donors were identified. We then determined each recipient's vital status and, if deceased, the cause(s) of death identified by matching the recipient's personal identifiers with the Centers for | [
-0.017818034,
-0.017389154,
0.022938607,
-0.026018748,
-0.006771113,
0.02989167,
-0.01209313,
0.006007576,
-0.03755953,
-0.007771834,
-0.006985553,
0.01061804,
-0.0025472902,
0.00016560228,
-0.018428864,
0.014581936,
0.018649802,
0.014088074,
0.016882295,
-0.01061804,
-0.021184096,
0.022340773,
-0.01485486,
-0.0073819426,
0.012866414,
0.024784092,
0.00047477393,
-0.0049776128,
0.006361727,
0.007804325,
-0.01155378,
0.008766057,
-0.029111886,
0.004548732,
-0.008831039,
-0.016986266,
-0.0018146193,
0.0030931379,
0.018389875,
-0.00014763074,
0.0122685805,
0.02235377,
-0.010631037,
-0.01787002,
0.0046657,
0.012034646,
-0.0018568574,
-0.017155219,
-0.012242588,
0.011469304,
0.038989134,
0.020625252,
-0.022288788,
0.0066249035,
0.008766057,
-0.029969648,
0.0061635324,
0.016037531,
0.0071675023,
-0.032101054,
-0.0076158773,
-0.008577609,
-0.019611534,
-0.0057314024,
-0.0111249,
0.009773276,
0.0008853782,
0.015101791,
-0.013295295,
0.0099552255,
0.033140764,
0.016882295,
0.00081633497,
0.0064104632,
0.02490106,
0.002027435,
0.006150536,
-0.005507215,
-0.008603602,
0.005286277,
0.021859908,
-0.012599988,
-0.011189882,
0.026252683,
0.0027617302,
-0.018948719,
0.0052667824,
0.024862071,
0.014789878,
-0.01058555,
-0.0007225174,
0.017480128,
-0.013646197,
0.030307554,
-0.0024514417,
0.01575161,
0.019390596,
0.040054835,
-0.006849091,
-0.015218758,
-0.006537178,
-0.0052147964,
-0.02540792,
-0.022912614,
-0.021340052,
0.0034635346,
0.010748005,
-0.010559557,
0.0047631725,
-0.0007627249,
-0.02325052,
0.043095987,
0.0012866415,
-0.030255567,
0.018779766,
-0.0010990062,
-0.008291689,
-0.00843465,
-0.0042010793,
-0.018077962,
0.020612255,
0.008064252,
0.0133732725,
-0.01298988,
0.027682286,
0.027110444,
-0.035324156,
0.006641149,
0.005263533,
-0.01840287,
0.0037299604,
-0.01672634,
0.018337889,
0.0074729174,
-0.022262795,
0.014932838,
-0.025394922,
0.0004621837,
-0.010397103,
-0.028592031,
-0.0077913287,
0.023341496,
-0.009591327,
0.024394201,
-0.013197822,
0.019728502,
0.03529816,
0.009617319,
-0.004538985,
0.005809381,
0.010890964,
0.0035025238,
0.041770358,
-0.03498625,
-0.0016383559,
0.0013589337,
-0.0021509004,
0.010358113,
-0.018597817,
-0.006875084,
-0.023328498,
0.0025667846,
0.0005661547,
-0.001155053,
0.020430306,
0.018857744,
-0.02213283,
-0.0127169555,
0.027422357,
-0.01862381,
-0.017207203,
0.023874346,
-0.034466393,
0.01607652,
0.0047989124,
0.016713342,
0.00069165096,
0.020781208,
-0.045071438,
-0.011098906,
-0.01259349,
0.028566038,
0.036441844,
0.023848353,
-0.011904682,
-0.0007505408,
0.033426683,
-0.010754502,
-0.0005263533,
-0.011898184,
0.014490961,
0.008623097,
0.016349444,
-0.03651982,
-0.6450362,
-0.02390034,
0.004194581,
0.0105075715,
0.0012638977,
0.013724175,
0.006179778,
0.009968222,
-0.024719112,
0.035662062,
0.006527431,
0.030125603,
0.011462805,
-0.005052342,
-0.018480849,
-0.021573987,
-0.0200924,
0.004714436,
0.015790598,
0.014425979,
-0.0108194845,
0.013776161,
-0.016141502,
0.0141660515,
-0.0044415123,
0.023016585,
0.020768212,
-0.0165054,
0.0065859146,
-0.015933558,
-0.0112678595,
0.012346559,
0.01546569,
-0.001980323,
0.054376844,
-0.0051400675,
0.0013499988,
0.008473638,
-0.008616598,
-0.0012305946,
0.0016464787,
-0.008213711,
0.03197109,
0.0006555048,
-0.015647639,
0.034440402,
-0.002971297,
0.0049451217,
0.010650531,
0.0031743653,
0.020807201,
0.01711623,
-0.021976875,
0.0048281546,
-0.00832418,
-0.0025862793,
0.02644763,
-0.016622366,
0.024264237,
-0.0068685855,
-0.024251241,
-0.002977795,
0.0077523394,
-0.0078498125,
0.009084468,
-0.00588411,
-0.010462084,
0.012742949,
0.0085061295,
-0.030333545,
0.018779766,
0.022769654,
0.0051725586,
-0.003785195,
0.020976154,
0.008857031,
0.008512627,
-0.0006664705,
0.0016570382,
-0.00523754,
-0.033426683,
-0.009396381,
-0.027214415,
0.022418752,
0.00889602,
-0.001959204,
-0.003941152,
0.01768807,
0.0142700225,
0.008889522,
-0.008584107,
-0.00028774794,
-0.002253247,
-0.032854844,
-0.018610813,
0.032490946,
0.008330679,
-0.0019137167,
-0.0052700313,
-0.0004678696,
-0.01270396,
-0.012418039,
0.028254125,
-0.033374697,
0.0051725586,
0.009396381,
-0.049828112,
-0.010592048,
0.05294724,
-0.03888516,
-0.016193487,
-0.008356671,
0.012431036,
-0.00263664,
0.00048614576,
-0.03269889,
0.007901798,
0.026434632,
0.013867135,
-0.028747987,
0.038755197,
0.010098185,
0.0017935002,
0.0059458427,
0.0017626338,
0.014789878,
0.0043375413,
-0.03836531,
-0.027604306,
-0.014971827,
0.016570382,
-0.010631037,
0.03425845,
-0.009428872,
0.0031776144,
-0.03293282,
0.009103963,
-0.0026967484,
-0.02540792,
-0.018714784,
0.0012663346,
-0.003538264,
-0.0125090135,
0.012794934,
-0.006881582,
-0.0035480112,
-0.009591327,
0.009051977,
-0.0108519755,
-0.03433643,
0.010650531,
0.0034862785,
-0.017857023,
0.013880132,
-0.0074144336,
-0.010514069,
-0.005939345,
-0.007921292,
0.013074356,
-0.0049808617,
0.022314781,
0.02382236,
-0.011105405,
0.023094563,
-0.0022045106,
-0.030437516,
0.018415868,
-0.006101799,
-0.016570382,
-0.032101054,
0.00810974,
-0.014893849,
-0.013048363,
0.015439697,
-0.0037559532,
0.019104676,
-0.004685194,
-0.012138617,
-0.000442283,
0.013223815,
-0.0186628,
-0.012801432,
-0.00008386725,
0.00091868144,
0.020573266,
0.016193487,
-0.0064429543,
0.016336447,
0.00028429576,
0.02744835,
0.00059864565,
-0.0015888072,
-0.014893849,
0.017610092,
0.0016716591,
-0.0003773011,
0.016960273,
0.0064592,
0.00072657876,
0.01284692,
0.02375738,
-0.015829587,
0.03813137,
0.012203598,
0.027084451,
-0.015101791,
0.014620925,
-0.0051498148,
0.029683728,
0.011677246,
0.001006407,
-0.008675083,
0.013321287,
0.0024563153,
0.0026821275,
0.03197109,
-0.016440418,
0.002971297,
-0.015868578,
-0.01779204,
-0.0027276147,
0.010773997,
0.016531393,
0.017168215,
0.007745841,
0.01532273,
0.014231034,
-0.016687348,
0.0004236007,
-0.015127784,
-0.012950891,
0.010773997,
0.00047071255,
-0.008668584,
-0.0015132658,
0.009968222,
0.00997472,
-0.016323451,
0.004087361,
0.014075077,
-0.0056566736,
-0.011235368,
0.0019364603,
0.016011538,
0.03347867,
0.019065686,
0.026772538,
-0.006400716,
-0.02744835,
0.020183375,
-0.00530902,
-0.003677975,
-0.016414424,
-0.009844757,
-0.008675083,
0.0056274314,
0.009604324,
-0.009786272,
0.017753052,
0.008733566,
0.024277234,
-0.008980497,
-0.007934289,
-0.009201435,
0.021846911,
0.010644034,
-0.01851984,
-0.026330661,
-0.015426701,
0.033322714,
-0.02443319,
-0.03470033,
-0.009753781,
-0.0094028795,
0.012346559,
0.014529951,
0.004928876,
-0.0049451217,
0.016557386,
-0.0037721987,
-0.0204563,
-0.024719112,
-0.0060953014,
0.043095987,
-0.011462805,
-0.024264237,
0.0044869995,
0.0062350123,
-0.011241867,
0.033348706,
0.004678696,
-0.0063064923,
-0.012684464,
0.0058418717,
0.028280118,
-0.013321287,
0.02989167,
-0.0200924,
-0.012690963,
-0.006053063,
-0.013750168,
-0.007057033,
-0.019182654,
-0.010462084,
0.016817313,
0.020859186,
0.0020647994,
0.0032523435,
0.0038924152,
-0.01636244,
-0.0005779327,
0.01101443,
-0.016401429,
-0.019390596,
-0.0043505374,
0.031009357,
-0.017376157,
0.02791622,
0.017181212,
-0.016323451,
-0.006940066,
-0.022990592,
-0.013464248,
-0.022938607,
0.052479375,
0.029787699,
-0.023666404,
0.010767499,
0.0028965678,
-0.002912813,
-0.0058321245,
-0.0037786968,
0.0247581,
0.017610092,
0.012528508,
-0.003713715,
0.020820197,
0.025251962,
0.017844027,
0.0106115425,
-0.02382236,
-0.0068425927,
-0.005120573,
0.006426709,
0.034596357,
-0.0247581,
0.022912614,
0.036935706,
0.018129947,
-0.0024416945,
0.011644755,
0.03142524,
-0.001994944,
0.002698373,
-0.007661365,
0.030021632,
-0.020573266,
0.03246495,
-0.008311183,
0.005224544,
0.0044512595,
-0.004964616,
0.016921284,
0.019637527,
0.018168936,
0.013048363,
0.007700354,
0.012255584,
0.037273612,
-0.012197101,
0.00591985,
-0.02070323,
-0.007154506,
-0.02302958,
0.041536424,
0.001056768,
-0.016453415,
-0.010877968,
0.014425979,
-0.0067971055,
0.011209376,
-0.012457028,
-0.00030561796,
0.0073689464,
-0.015530672,
-0.03347867,
0.0036357366,
0.007466419,
-0.01252201,
-0.0012590241,
-0.03197109,
0.0020290595,
-0.021664962,
-0.028306112,
-0.012398545,
0.012944392,
-0.007875805,
0.017207203,
0.011079412,
0.0050718365,
0.014581936,
-0.03688372,
0.021392038,
-0.00046380825,
-0.04800862,
0.008259198,
-0.003401802,
-0.016258469,
-0.007531401,
0.0028608276,
-0.004058119,
-0.015699625,
-0.010994935,
0.03178914,
0.01015667,
0.0151667725,
0.012762443,
0.016570382,
0.006940066,
-0.016245473,
0.0119241765,
0.018961715,
-0.025758822,
-0.011833202,
0.006192774,
-0.020391317,
0.00007701369,
-0.0127169555,
0.0074469247,
-0.008135732,
-0.028436074,
0.0041198516,
0.009376886,
0.001155053,
0.026070734,
-0.018610813,
0.040132813,
0.02135305,
0.026174705,
0.008844035,
0.011436813,
-0.0031889863,
0.023081567,
-0.0037754478,
0.0058678645,
-0.00818122,
0.022899618,
-0.0056826663,
-0.012080133,
0.03345268,
0.022431748,
-0.032049067,
-0.015543668,
-0.012197101,
-0.0022971097,
0.05289526,
0.0043147975,
0.010637536,
-0.029631741,
-0.0076483684,
0.012294574,
0.008246202,
0.0035610076,
-0.008369667,
-0.023653409,
0.0065924125,
-0.0043050502,
-0.004964616,
0.010442589,
-0.044577576,
-0.015660636,
0.009857752,
-0.02263969,
0.0046689487,
-0.020300342,
-0.02174294,
-0.009311905,
-0.0048216563,
-0.0068880804,
-0.03215304,
0.0032588418,
-0.0077523394,
0.047098875,
0.0033433181,
0.035142206,
0.0069270693,
-0.0057963845,
0.010072193,
0.005851619,
0.010410098,
-0.004584472,
0.026031746,
-0.0049711145,
0.010689521,
-0.0068166,
-0.0071675023,
-0.005296024,
0.0002063175,
0.01675233,
0.010202156,
-0.007388441,
-0.019923447,
-0.002012814,
-0.050711866,
-0.013594211,
-0.0077133505,
0.0025083008,
0.0069010765,
-0.061342902,
0.00023799617,
0.014945835,
-0.0077588377,
-0.012528508,
-0.0147119,
-0.0046364577,
-0.012658472,
-0.0013426883,
-0.0062902467,
0.0032750873,
0.016336447,
0.0021102868,
-0.003645484,
-0.0090584755,
0.018935723,
0.0042140754,
0.00073023397,
0.02838409,
-0.011293853,
-0.0141660515,
0.009396381,
-0.037195634,
-0.0011867317,
0.005435735,
-0.011072914,
-0.037195634,
-0.019377599,
-0.009389883,
-0.008668584,
-0.01571262,
0.00792779,
-0.009929232,
0.019689513,
-0.021755936,
-0.039015125,
0.014205041,
-0.012320566,
0.033062786,
-0.0057736407,
0.02023536,
0.031347264,
-0.009981218,
-0.031373255,
0.0014832116,
0.022652688,
-0.0018519838,
0.0027536075,
0.026746545,
-0.032231018,
-0.023484455,
0.025758822,
0.03269889,
-0.02999564,
-0.02557687,
0.04348588,
0.0072129895,
-0.01395811,
-0.009370388,
-0.018753773,
-0.012210097,
0.00036917836,
-0.00907797,
-0.005403244,
0.0070960224,
-0.005851619,
-0.0072129895,
0.025784813,
-0.019962436,
0.01607652,
0.005575446,
-0.018610813,
-0.013425258,
-0.027760264,
-0.017194208,
0.015049806,
-0.01191118,
0.010013709,
-0.015829587,
-0.022184817,
0.009558836,
-0.007011546,
-0.005120573,
-0.008571112,
-0.024251241,
0.035818018,
-0.0014539697,
0.0010916957,
0.018038973,
0.016908288,
-0.005114075,
-0.013607208,
0.003677975,
-0.010676525,
-0.026954487,
-0.018636806,
0.01697327,
0.029839683,
-0.0065306798,
0.0071869968,
-0.0112678595,
-0.008246202,
-0.025005031,
-0.031295277,
0.008356671,
-0.02429023,
-0.016882295,
0.0015961176,
0.018428864,
-0.023315502,
-0.008278693,
-0.012697461,
0.0012752695,
0.034180474,
-0.014945835,
0.02669456,
0.016947277,
0.017012259,
-0.036701772,
-0.011495296,
0.0087140715,
-0.0077848304,
0.030255567,
0.012041144,
-0.014620925,
-0.019780487,
0.0043862774,
0.008597104,
0.007882304,
-0.018129947,
0.027552322,
-0.014010095,
0.012197101,
0.005068587,
-0.030879393,
0.017428143,
-0.017103232,
-0.0040418734,
0.010709016,
-0.014789878,
0.00836317,
0.006907575,
0.006007576,
0.0037234623,
-0.012099627,
-0.03093138,
-0.015270744,
0.023237525,
-0.019234639,
0.0102996295,
0.004620212,
-0.030437516,
-0.007914794,
0.008233205,
0.02551189,
0.011748726,
-0.012216595,
-0.025901781,
-0.004639707,
0.017960994,
0.020963157,
0.010936452,
0.0114043215,
-0.018948719,
-0.017090237,
0.0049711145,
-0.023445467,
0.02019637,
0.0011266235,
0.0070310403,
-0.031763148,
-0.007251979,
-0.04065267,
0.018675795,
0.007563892,
0.028072177,
0.032386974,
0.038755197,
0.01768807,
0.023237525,
-0.007862808,
0.025745824,
0.004168588,
-0.007869307,
0.04195231,
0.01320432,
0.010208655,
0.007674361,
-0.032334987,
0.00036166483,
0.014296016,
0.01079999,
0.006179778,
0.006455951,
0.0038339314,
-0.0011729231,
0.004285556,
-0.006875084,
-0.023809364,
0.01672634,
-0.004506494,
-0.016882295,
-0.010221651,
0.009019487,
-0.0018649802,
-0.0044772523,
-0.0015449445,
0.003440791,
0.022223806,
0.0011298726,
-0.016193487,
-0.024303226,
0.023224527,
-0.016206482,
-0.0015522549,
0.022938607,
0.00082567614,
0.0051075765,
-0.001315071,
0.0051400675,
0.011742228,
-0.0074534225,
-0.006979055,
-0.028280118,
-0.0050490927,
0.00064210227,
0.009513348,
0.013223815,
0.010169665,
-0.016934281,
0.0073494515,
-0.01560865,
-0.026278676,
-0.01787002,
0.014283019,
-0.0073104626,
-0.019611534,
0.0041555916,
0.016271465,
-0.022756658,
-0.0061635324,
-0.014724896,
-0.02159998,
-0.009688799,
-0.010988438,
-0.0056859152,
-0.008519126,
-0.009207934,
-0.0029258095,
-0.036415853,
-0.0016879046,
-0.0046267104,
0.17539911,
-0.020274349,
-0.005468226,
0.022002868,
-0.013158833,
-0.024082288,
0.008278693,
-0.01195017,
-0.0026626328,
0.026265679,
0.041458447,
-0.00022154763,
-0.004707938,
0.000047492624,
-0.0022792397,
-0.0014474716,
-0.03576603,
-0.03888516,
-0.004262812,
-0.018077962,
0.009994214,
0.008207212,
0.007466419,
-0.014153056,
0.03680574,
0.011930675,
-0.0029696724,
0.01499782,
0.016492404,
0.0071675023,
-0.032308996,
0.00635198,
0.0032994554,
-0.0008366418,
-0.011397824,
0.011241867,
-0.011618762,
-0.02773427,
0.002407579,
0.009448367,
-0.01779204,
0.014490961,
-0.029683728,
-0.0093314,
-0.0058548683,
0.0312173,
0.011982661,
-0.037403576,
-0.011670748,
-0.01815594,
-0.04242018,
-0.015946556,
-0.036545813,
0.0052830274,
0.024420194,
-0.003918408,
0.028644016,
0.035064228,
-0.004503245,
-0.024511168,
-0.018389875,
-0.008986996,
-0.022171821,
0.03358264,
-0.007804325,
0.03103535,
-0.009409377,
-0.0120606385,
0.02390034,
-0.0013954861,
-0.006056312,
-0.022366766,
-0.0014490961,
0.0011201253,
0.013262804,
-0.027994199,
0.023484455,
0.033608634,
0.0240433,
0.003609744,
0.005260284,
0.002267868,
0.0015075798,
0.0046689487,
-0.0075768884,
-0.036181916,
0.021418031,
0.0020485541,
-0.017324172,
0.011898184,
0.014231034,
0.00839566,
-0.013919121,
-0.007420932,
0.0066801384,
0.01764908,
0.0071285134,
-0.019923447,
0.01438699,
-0.03225701,
-0.026200699,
0.062954456,
0.00037181826,
0.0026447629,
-0.020365324,
0.01660937,
-0.0049126307,
0.015361719,
0.011813708,
-0.015647639,
-0.01277544,
-0.010702517,
-0.0056469264,
-0.0015904318,
0.011521289,
0.049984068,
-0.00900649,
-0.030333545,
0.013054862,
-0.00488014,
0.016284462,
-0.04405772,
0.0055559515,
0.02647362,
0.016557386,
0.0003951711,
0.020768212,
-0.013139338,
-0.017220201,
-0.01725919,
0.004561729,
-0.023887342,
-0.0018438611,
-0.02820214,
0.00331895,
0.015023813,
-0.013880132,
-0.010221651,
0.0082527,
0.012424537,
-0.012729952,
-0.003785195,
0.018779766,
-0.013048363,
-0.0005275717,
-0.020612255,
0.026902502,
-0.0071350113,
-0.015660636,
0.012385548,
-0.015634643,
-0.0035350148,
-0.02555088,
-0.0023279763,
0.009552338,
-0.017285183,
-0.014309012,
-0.037429567,
0.009357392,
-0.0099552255,
-0.03963895,
0.031295277,
0.024719112,
-0.016999261,
0.0045324867,
0.0040158806,
-0.16261068,
0.021041136,
-0.006472196,
0.012885909,
0.037507545,
-0.024394201,
0.006261005,
0.010052699,
0.0014694029,
-0.0052440385,
0.034310438,
-0.008278693,
-0.0100591965,
0.007940787,
-0.005445482,
-0.025446909,
-0.02479709,
0.03199708,
0.0071090185,
-0.0027974704,
0.036649786,
0.0072714733,
0.011846199,
-0.033920545,
0.007225986,
0.0024790592,
-0.018233918,
-0.008986996,
-0.0035317657,
-0.024992034,
-0.006985553,
-0.008584107,
0.010722011,
-0.02095016,
-0.017337168,
-0.0023019835,
-0.008876526,
-0.011592769,
-0.0064494526,
-0.011651252,
0.015231755,
0.033868562,
-0.030541489,
-0.005617684,
-0.002722741,
0.03555809,
0.01022815,
-0.025706835,
0.00649494,
-0.0029469286,
0.01176822,
-0.0058061318,
0.018168936,
0.015335726,
0.0064527015,
-0.0025001783,
-0.0011509918,
-0.008993493,
0.009701796,
0.014490961,
-0.020170378,
-0.034128487,
0.00059417816,
0.0060725575,
-0.014776882,
-0.01607652,
0.00059174135,
-0.008772555,
-0.0011347462,
0.015660636,
-0.027032467,
0.003710466,
0.004103606,
-0.008155227,
0.04166639,
0.03269889,
-0.022184817,
0.01840287,
-0.0128209265,
-0.050036054,
-0.00818122,
0.016583377,
-0.02687651,
-0.01736316,
-0.030385531,
0.0082981875,
0.024446188,
-0.00007604912,
0.009064973,
-0.027656293,
-0.019988429,
-0.012983382,
0.009779775,
-0.013516233,
-0.010929954,
0.021937886,
-0.00674512,
-0.009513348,
0.00022479672,
0.01725919,
0.013386269,
-0.013087353,
-0.029761706,
0.004171837,
0.012788435,
-0.021690955,
-0.0013784283,
0.023016585,
0.03649383,
-0.019546552,
0.011495296,
0.024277234,
0.018350886,
0.0017577601,
-0.021366045,
0.03064546,
-0.011865693,
-0.011800711,
0.01862381,
0.007018044,
0.056664206,
0.0135812145,
0.007148008,
0.00882454,
-0.03449239,
-0.0025245463,
-0.10641434,
0.009935731,
0.0030444015,
0.009636814,
-0.0039021624,
0.01966352,
-0.006056312,
0.010884467,
-0.0025083008,
0.019364603,
-0.020794205,
-0.020274349,
-0.0011266235,
0.004230321,
0.031087335,
0.0069205714,
0.014646918,
-0.015660636,
-0.025992755,
0.023068571,
0.0011136271,
0.0009771652,
-0.0222498,
-0.016193487,
-0.02070323,
-0.0077588377,
-0.024966042,
0.01514078,
0.0077913287,
0.011046921,
0.015634643,
-0.0017967492,
-0.0075119063,
-0.02400431,
-0.03649383,
0.00025403858,
-0.014620925,
-0.021703951,
0.028644016,
-0.017947998,
-0.0039086607,
0.0021086624,
0.027578315,
0.0064851926,
0.020508284,
0.0050360966,
-0.029501777,
0.011703238,
-0.014945835,
-0.020157382,
-0.024615139,
-0.004240068,
-0.01202165,
-0.010221651,
0.028644016,
-0.021664962,
-0.001442598,
0.010754502,
-0.04800862,
-0.005585193,
-0.013386269,
0.014322008,
-0.021262074,
-0.0041425955,
0.0073494515,
-0.032854844,
-0.020807201,
-0.020183375,
0.035142206,
-0.0455653,
-0.0023555935,
-0.012872912,
-0.017311174,
-0.010241146,
-0.02263969,
0.0053869984,
-0.000757039,
0.021301063,
0.0060595614,
-0.030359538,
-0.020365324,
0.0048281546,
0.014633922,
-0.014789878,
0.035662062,
0.025173984,
-0.012203598,
-0.01672634,
0.013301793,
-0.013100349,
-0.015543668,
0.019455578,
-0.013724175,
0.010293132,
0.0003856269,
0.0080577545,
0.020170378,
-0.015413704,
0.0036844732,
0.032958813,
-0.028046183,
-0.0070635313,
-0.054844715,
0.017064244,
0.012996377,
-0.01485486,
0.0023312252,
-0.0052115475,
0.012729952,
-0.0035545093,
-0.0013069483,
0.016440418,
-0.020495288,
0.015426701,
-0.026265679,
0.02019637,
-0.00900649,
-0.014828867,
0.032672893,
0.014412983,
0.027032467,
0.040236786,
0.01094295,
-0.0019965686,
0.022587705,
0.02867001,
0.01764908,
0.018324893,
-0.0026626328,
0.038937148,
0.013412262,
-0.004512992,
0.006537178,
-0.01980648,
0.0076548667,
0.0019104675,
0.0029339322,
-0.018987708,
-0.016713342,
0.038651228,
0.025212973,
0.039664946,
-0.013646197,
-0.027994199,
0.0050978293,
-0.015842585,
-0.01245053,
0.012145115,
-0.03584401,
0.027292393,
-0.0069205714,
-0.01105342,
0.0078498125,
0.0064527015,
-0.008330679,
-0.02999564,
-0.022483734,
0.040704656,
0.021898897,
-0.018727781,
0.015010816,
-0.012359556,
0.032023076,
-0.024082288,
-0.01334728,
0.0049093817,
0.031477228,
-0.024264237,
-0.029293835,
0.016999261,
0.025251962,
-0.017999982,
-0.014646918,
-0.0028039685,
-0.00037831644,
-0.007388441,
-0.006121294,
-0.0065306798,
-0.017064244,
0.014594932,
-0.00635198,
0.022769654,
-0.0012240963,
0.0031662425,
-0.030983364,
0.00728447,
0.028592031,
0.001341876,
-0.008798548,
0.025953766,
-0.014542947,
0.0126129845,
0.0024027054,
0.02418626,
0.007973278,
0.01941659,
-0.00083582953,
0.023848353,
-0.029189864,
-0.008993493,
0.013776161,
0.024511168,
-0.023562433,
0.016583377,
-0.0018617312,
-0.048424505,
-0.014724896,
-0.0068230983,
-0.04187433,
-0.04330393,
-0.018974712,
0.0038404297,
0.031841125,
0.0042140754,
-0.00017829405,
0.0013305042,
-0.014672911,
-0.019702509,
-0.0022646189,
0.0103711095,
-0.012158112,
0.0312173,
0.005572197,
-0.0003143499,
0.002228879,
0.019468574,
0.01675233,
-0.0015944932,
0.0118202055,
-0.015816592,
0.013659193,
-0.0016221104,
0.0036942204,
0.012950891,
-0.01868879,
-0.0029453041,
0.0043602847,
-0.041354474,
0.013015873,
0.0013581215,
0.00051173236,
0.06685337,
-0.002695124,
-0.004181585,
-0.0008796923,
-0.02095016,
0.0099552255,
0.012937894,
0.0182989,
0.026018748,
-0.029475786,
-0.013763164,
-0.0071025207,
0.023510447,
-0.045435335,
-0.036259893,
0.015816592,
-0.0050718365,
0.0045779743,
0.00050401577,
0.020378321,
0.011430315,
-0.0059458427,
0.022652688,
0.009630316,
-0.013555222,
-0.0012224718,
0.021677958,
-0.025615862,
-0.011365333,
0.007251979,
0.010013709,
0.0024725609,
-0.023406476,
-0.010436092,
0.015725616,
-0.021509005,
-0.01779204,
-0.014322008,
-0.004399274,
-0.024459183,
-0.0033563145,
0.020937165,
-0.019247636,
-0.01599854,
-0.015985545,
-0.051283706,
-0.011339339,
-0.026486618,
0.010143673
] |
Altered DNA methylation occurs ubiquitously in human cancer from the earliest measurable stages. A cogent approach to understanding the mechanism and timing of altered DNA methylation is to analyze it in the context of carcinogenesis by a defined agent. Epstein-Barr virus (EBV) is a human oncogenic herpesvirus associated with lymphoma and nasopharyngeal carcinoma, but also used commonly in the laboratory to immortalize human B-cells in culture. Here we have performed whole-genome bisulfite sequencing of normal B-cells, activated B-cells, and EBV-immortalized B-cells from the same three | [
-0.02577779,
-0.01524662,
-0.0048791803,
-0.030859997,
-0.04618521,
-0.004744921,
-0.00046049312,
-0.008134151,
-0.027559184,
0.013281849,
-0.020263335,
-0.0010446031,
0.0026704508,
0.0019025529,
-0.0077477456,
0.005900861,
0.032065056,
-0.010766943,
-0.0029340575,
0.021049242,
-0.05600906,
0.02407499,
0.019202359,
-0.025266951,
-0.013753395,
0.022778241,
0.00804901,
-0.045373105,
-0.011258136,
-0.0011125514,
0.017106604,
0.010059626,
-0.0041489406,
-0.0041194693,
-0.0077739423,
-0.0047252732,
0.009895895,
-0.00958808,
0.030047892,
-0.015875347,
0.008252037,
0.017028011,
-0.0010978156,
-0.00015503269,
-0.0065263133,
0.005877939,
0.013635508,
-0.023564149,
0.0026639015,
0.014211841,
0.02252937,
0.0049217506,
-0.00051493366,
-0.004207884,
-0.011683836,
-0.0021219524,
0.008107954,
0.021154031,
0.00013016605,
-0.013380088,
-0.008533654,
-0.011199193,
-0.03347969,
0.0077411965,
-0.0033794055,
0.0072434545,
0.011336726,
0.023275983,
0.008009715,
0.016726747,
0.033505887,
0.006483743,
-0.023839217,
0.0025623883,
0.00977146,
0.004833336,
-0.042465243,
-0.019346442,
0.010066175,
0.004728548,
0.021533886,
-0.0013303135,
-0.0041849613,
0.009358858,
0.0011166446,
0.009620827,
0.00036982715,
-0.007210708,
0.021953037,
-0.012810305,
0.009529138,
0.016163513,
0.021350507,
0.01182137,
-0.014093955,
0.033453494,
0.019935872,
0.036937688,
0.02706144,
-0.029497756,
-0.0053998446,
-0.00054645183,
-0.0019156514,
-0.0018386978,
-0.015102537,
0.00338268,
0.014434515,
-0.008206192,
0.008946256,
0.008782525,
-0.011539753,
0.020970652,
-0.0052983314,
-0.047442663,
0.05071728,
0.017250687,
0.018534336,
-0.0033090012,
-0.0048038643,
0.0026426164,
-0.011290882,
0.029576348,
0.007361341,
-0.018626025,
0.02603976,
-0.0057797004,
-0.03203886,
-0.012063691,
0.004122744,
-0.0027539534,
0.019058276,
0.008009715,
-0.019713199,
0.0016176612,
-0.02304021,
-0.0025263675,
0.004188236,
-0.030388452,
-0.014486909,
-0.019346442,
0.0064444477,
0.022555567,
-0.014984651,
0.0018648948,
-0.014080856,
0.018953487,
-0.01687083,
0.013157414,
0.009299914,
-0.0014203654,
-0.01620281,
-0.024297664,
0.043801285,
-0.015574082,
-0.0018747187,
0.017224489,
-0.008644991,
0.030886194,
-0.025424132,
-0.014486909,
-0.00007603253,
0.004748196,
0.014513106,
0.015102537,
0.0064280746,
0.03177689,
0.002968441,
-0.010112019,
-0.012319112,
-0.026419615,
-0.015181128,
0.033558283,
-0.047075905,
0.0038673235,
-0.029078605,
0.014028463,
-0.009260619,
0.020708682,
-0.014722682,
-0.013831985,
-0.014775075,
0.031017179,
0.026799472,
-0.0007539807,
-0.030990982,
-0.0009913906,
0.00509858,
-0.026773274,
-0.0012394428,
-0.021101637,
-0.0043224953,
0.016661255,
0.016477877,
-0.008206192,
-0.6375288,
-0.040238503,
-0.0096011795,
0.010780042,
0.00096764957,
0.017198293,
0.020328827,
-0.011303981,
-0.012188127,
0.019569116,
-0.031069573,
0.016556468,
0.021442197,
-0.014211841,
-0.0065557845,
-0.040238503,
-0.012862698,
-0.016831536,
0.028423682,
-0.002677,
-0.023420066,
-0.0038182042,
-0.0022136415,
0.0094636455,
-0.0142904315,
0.016635058,
0.014447614,
0.007040428,
0.025109768,
0.03819514,
-0.036963884,
0.033532087,
0.0013065725,
-0.021389803,
0.044770572,
-0.0016225731,
0.014395219,
0.026524404,
0.0006753899,
0.016307596,
0.026904259,
-0.018036595,
-0.0072369054,
0.00069994957,
-0.030047892,
0.02269965,
-0.0039819353,
0.006287266,
0.021298114,
-0.000099313016,
-0.0051935436,
0.0055210055,
-0.014919158,
-0.021232622,
0.03214365,
0.02294852,
0.0051542483,
-0.01960841,
0.017119702,
-0.0070993714,
0.014447614,
0.022778241,
0.0038149296,
-0.021861348,
0.001267277,
0.004374889,
-0.008933157,
0.018023496,
0.00044616667,
-0.0060711415,
0.021206424,
0.0282665,
0.0037330643,
-0.01405466,
0.016346892,
0.035313476,
-0.0009864786,
0.004001583,
-0.015403802,
-0.016399285,
0.0026704508,
-0.002406844,
-0.02973353,
0.003864049,
0.019857282,
0.0005268041,
-0.014447614,
0.01867842,
-0.01609802,
-0.00012402615,
-0.004489501,
0.017800823,
-0.010321595,
-0.033715464,
-0.01679224,
0.0015153293,
0.010734197,
0.013294948,
-0.002084294,
-0.01979179,
-0.027454395,
-0.021206424,
-0.000106834406,
0.02192684,
0.014788174,
0.0008174265,
-0.025004981,
0.00066720333,
0.04694492,
-0.01575746,
0.01875701,
-0.0072172573,
-0.0011330177,
0.016975619,
-0.017329277,
-0.017551951,
0.001516148,
-0.0039197174,
-0.012567983,
-0.022555567,
-0.01002688,
-0.00033667163,
-0.0015718165,
-0.021822052,
0.022044726,
0.013753395,
-0.0020630092,
-0.0004207884,
-0.006022022,
-0.02217571,
0.005979452,
-0.02158628,
0.012116086,
-0.018534336,
0.035785023,
-0.003037208,
0.020944456,
0.00066351943,
-0.019752495,
-0.008887312,
-0.015547885,
-0.0043814387,
0.010642508,
0.0044534802,
-0.009470195,
0.014041561,
-0.017866313,
-0.002603321,
0.0011665826,
0.01773533,
0.033348706,
-0.00046376773,
-0.024363156,
0.025214557,
0.011775525,
-0.0029700783,
0.0017994024,
-0.02116713,
0.0027375803,
-0.012155381,
0.0038182042,
0.011847567,
0.008016264,
-0.0040801736,
0.017041111,
0.010969969,
0.0016414021,
0.0070076818,
0.0017502832,
-0.0368591,
0.023996398,
0.006673671,
-0.013635508,
0.003955738,
-0.015037045,
0.006621277,
-0.020355023,
-0.005707659,
-0.014486909,
-0.005206642,
0.0009087064,
-0.008664639,
-0.00012607279,
0.0010871731,
0.041181594,
-0.00083993946,
0.014264235,
-0.013818887,
0.012489392,
0.032353222,
-0.0053998446,
0.030650422,
-0.0043912623,
0.008317529,
0.03298195,
-0.025450328,
-0.00263443,
-0.004031054,
0.016058726,
0.04120779,
-0.014329727,
-0.009443997,
0.009267168,
-0.007086273,
0.026930457,
-0.039426398,
-0.00950949,
-0.02947156,
0.010393636,
0.0007457942,
0.002125227,
0.024127383,
-0.023092605,
0.005491534,
-0.018770108,
0.000670478,
-0.026432713,
0.0054456894,
0.0064051524,
-0.003356483,
-0.0046892525,
0.016936323,
0.018626025,
-0.021376705,
0.02098375,
0.012790657,
0.005295057,
0.013268751,
0.007649507,
-0.0025787614,
0.010059626,
0.02364274,
0.008618793,
-0.0074726776,
0.008212741,
0.008592597,
0.01019716,
-0.0090379445,
0.03125295,
-0.003418701,
-0.003631551,
0.017106604,
-0.0040670754,
0.0007441569,
0.02928818,
0.005344176,
0.01609802,
0.0077215484,
-0.014775075,
0.0049741445,
-0.0113891205,
0.0064248,
-0.0046728794,
0.001760107,
-0.005180445,
-0.026000464,
-0.020145448,
0.018455746,
0.044246636,
0.0049741445,
0.0131901605,
-0.014696484,
-0.0039524636,
-0.010229906,
0.013144315,
-0.0038509504,
-0.000114713956,
-0.008245488,
-0.012351858,
0.006598355,
-0.016897028,
-0.019765593,
0.007826337,
-0.033532087,
0.026825668,
0.017355474,
0.0044698534,
0.02535864,
0.021127833,
0.022581764,
-0.0071321176,
-0.024520338,
0.021717265,
0.024612026,
-0.007675704,
-0.00074661284,
-0.0034121517,
-0.02330218,
-0.0009979397,
-0.011081306,
0.027742561,
0.011258136,
0.006683495,
-0.004967595,
-0.0072827497,
0.0050854813,
0.0040114066,
-0.013556917,
0.0010118568,
-0.002650803,
-0.0055963215,
-0.016687453,
-0.014185644,
0.0046728794,
0.016163513,
0.0013106657,
-0.0035103902,
0.005645441,
-0.012436998,
-0.030624226,
-0.010694901,
-0.016504074,
-0.016766043,
-0.02047291,
-0.0054784357,
0.011402219,
0.014761977,
-0.000871867,
-0.004024505,
0.0072369054,
-0.016111119,
-0.037068672,
-0.02218881,
-0.020525305,
0.033086736,
0.0044240085,
-0.021730363,
0.02920959,
0.006811205,
0.016464777,
0.0012312563,
-0.043460727,
0.026275532,
-0.020355023,
0.001566086,
0.016045626,
0.0023348024,
-0.0026491657,
0.016674353,
0.028371288,
0.0038935205,
-0.030021695,
-0.013687902,
-0.011585598,
-0.017591247,
-0.002814534,
0.02928818,
0.041338775,
0.018770108,
-0.007813238,
0.00018921151,
0.023092605,
-0.010039978,
-0.019320244,
-0.01601943,
0.013923675,
0.012607278,
0.028816637,
0.012417351,
-0.02758538,
0.0052033677,
0.016320694,
0.011886862,
-0.009286816,
0.012698968,
0.02073488,
0.0073875375,
0.010911026,
0.0043093967,
-0.0034416232,
-0.0011444789,
-0.0059172343,
0.013439031,
-0.009404702,
0.014539302,
-0.030545633,
-0.022372188,
-0.01662196,
0.00014398085,
0.016045626,
0.0027539534,
-0.01739477,
-0.034448978,
0.011913059,
0.003079778,
0.009142732,
0.023118801,
-0.0013565104,
0.0026196942,
-0.009077241,
-0.008775976,
-0.006683495,
-0.015312113,
-0.013818887,
0.0005751047,
-0.02365584,
-0.035732627,
0.009096888,
0.021861348,
0.006654023,
0.009836951,
-0.0068635987,
-0.011972003,
0.022725847,
-0.018049693,
-0.0030912391,
-0.0024101187,
-0.03400363,
-0.019372638,
-0.006408427,
0.013504524,
-0.007859083,
-0.034815736,
0.013740296,
-0.0044600293,
-0.0017093505,
0.006107162,
-0.0080752075,
-0.011507006,
0.028659454,
-0.006241421,
0.019713199,
0.004777667,
-0.002603321,
-0.005173896,
-0.018665321,
-0.023891611,
-0.014591697,
-0.009319562,
-0.028502272,
-0.016517172,
0.0036904942,
-0.024101187,
-0.016556468,
-0.006811205,
-0.025489625,
0.0038967952,
-0.004771118,
0.031829283,
0.027480591,
-0.0029864514,
0.0071845115,
0.00064878364,
-0.0071910606,
0.020407418,
-0.019673903,
0.040055126,
0.0010372351,
-0.0063069137,
-0.009745263,
0.012037495,
0.00039315879,
0.011055109,
-0.0064640953,
-0.0066016293,
0.017840117,
0.0013769767,
-0.01620281,
-0.02440245,
-0.003562784,
0.028502272,
0.013740296,
0.013078824,
-0.031383935,
0.008644991,
0.0039819353,
0.0071976096,
-0.0022693102,
0.02150769,
-0.030545633,
0.0038083803,
0.04812378,
-0.012057142,
-0.013039527,
-0.012567983,
0.001208334,
-0.008933157,
0.0011935981,
-0.00479404,
-0.0015153293,
0.003546411,
0.0026278808,
0.05320599,
0.023773724,
0.03332251,
-0.02269965,
0.009784558,
0.01979179,
0.0124959415,
-0.010956871,
-0.01594084,
0.019123768,
-0.02065629,
0.0068243034,
0.0072172573,
0.009751812,
0.018233072,
-0.01772223,
0.010747296,
0.026707781,
-0.008920059,
-0.015207325,
-0.0020957554,
-0.030833801,
-0.029864514,
0.010891379,
-0.011434965,
0.03520869,
-0.039426398,
-0.014382121,
0.041181594,
-0.00891351,
0.013347342,
-0.018599829,
0.0030830526,
-0.025542019,
0.01036744,
-0.01662196,
-0.0054456894,
0.0007891829,
-0.013439031,
-0.0055832234,
-0.0124239,
0.008527105,
0.014329727,
0.025463428,
0.0026851865,
-0.02355105,
0.024913292,
0.026878063,
-0.008959354,
-0.01660886,
-0.005969628,
-0.03161971,
-0.02124572,
-0.02176966,
-0.011782074,
-0.031724498,
0.0060252966,
-0.0036381003,
0.0071517653,
0.01894039,
-0.0062086754,
-0.009005199,
0.010917575,
-0.011637991,
0.029392969,
-0.046735343,
0.049983766,
0.0051607974,
-0.010969969,
-0.031855483,
-0.012581081,
-0.0035922558,
0.0046237605,
0.011880313,
0.02166487,
0.00209903,
-0.001177225,
0.020970652,
0.005046186,
-0.016438581,
-0.015338309,
0.017800823,
-0.013923675,
-0.0027965235,
-0.00020282164,
-0.024716815,
-0.012993683,
0.018599829,
-0.013216357,
0.025031177,
-0.0011706759,
-0.03245801,
-0.012404252,
0.019713199,
-0.013779592,
0.023000915,
0.006585256,
-0.015783658,
-0.016490975,
-0.020970652,
-0.012528688,
-0.008697385,
-0.02005376,
0.029261984,
0.009915543,
0.0019271126,
0.004230806,
-0.008035912,
0.0074661286,
0.0055537517,
-0.016176611,
0.041941304,
-0.015770558,
0.0065492354,
-0.0051542483,
0.006568883,
0.018652223,
0.020564599,
-0.008114503,
-0.028161712,
-0.036623325,
0.006889796,
0.01010547,
0.019582214,
-0.012456646,
0.010943772,
-0.019817986,
0.0072500035,
-0.025594411,
-0.01764364,
0.013131217,
-0.049093068,
0.00030249282,
-0.0049479473,
0.006817754,
0.039871745,
0.031907875,
0.017761527,
-0.0124959415,
0.036623325,
-0.007813238,
-0.0076691546,
0.021088539,
0.012194676,
-0.011552852,
-0.00089724525,
-0.015993234,
-0.0034710949,
-0.007171413,
0.00646737,
-0.026851865,
-0.040579062,
0.0014129976,
0.029104803,
0.01824617,
-0.029445363,
0.03607319,
-0.008933157,
0.02390471,
-0.0052459375,
-0.032746177,
-0.003302452,
-0.022411484,
0.013661705,
0.0032287731,
-0.02158628,
-0.01293474,
-0.0029880886,
-0.021442197,
-0.005114953,
-0.022712748,
-0.022974718,
-0.021219524,
-0.000026606269,
0.012450096,
0.013144315,
0.0065132147,
-0.0018059517,
-0.02183515,
0.00050879375,
0.0007985974,
0.016490975,
-0.01362241,
0.008952805,
0.004443656,
0.0076626055,
-0.024114285,
0.008455063,
-0.022031628,
-0.027271016,
-0.035523053,
0.0042177076,
-0.024743011,
0.02106234,
0.023917807,
-0.0010454217,
-0.032484207,
-0.03237942,
-0.04901448,
-0.0058189956,
0.013858182,
0.0009815666,
0.00522629,
0.00950949,
0.0066278265,
-0.008625343,
0.0061628306,
0.017185194,
0.007682253,
-0.0048038643,
0.015718166,
0.0016561379,
0.019215457,
0.03581122,
-0.009457096,
-0.001359785,
0.00008616338,
-0.0022234654,
-0.013543819,
0.016752943,
-0.009214775,
0.012371506,
-0.003174742,
0.012469744,
-0.0045222472,
0.011729681,
0.015914641,
-0.015168029,
-0.011186094,
0.015862249,
-0.00053744664,
-0.047442663,
-0.0059074103,
-0.0013745208,
0.01960841,
0.025450328,
-0.006981485,
-0.017879413,
0.015233521,
-0.013910576,
0.02039432,
0.01660886,
0.0029438813,
0.011867215,
-0.01319671,
-0.011467711,
-0.017709132,
-0.016582664,
-0.045268316,
-0.01053772,
0.013380088,
-0.002809622,
-0.0025623883,
-0.003991759,
0.0027948862,
-0.015285916,
0.002629518,
-0.0022152788,
-0.011572499,
-0.030859997,
0.028580863,
-0.011814821,
-0.01139567,
-0.005877939,
0.0004572185,
-0.018298564,
-0.0026524405,
-0.006116986,
0.0037723596,
-0.0038771473,
-0.0032467835,
0.0034317994,
0.003487468,
-0.0072762007,
0.0022578489,
-0.014460712,
-0.017604345,
-0.0050494606,
0.18044454,
-0.010570466,
-0.01045258,
0.012476293,
-0.024873996,
-0.018979684,
0.01036089,
0.009666672,
0.01096342,
-0.0094178,
0.02724482,
0.010491875,
-0.0022431132,
0.009653573,
0.03298195,
-0.014251136,
-0.024638224,
-0.0060416698,
-0.0071976096,
-0.03193407,
0.0188356,
-0.011539753,
0.000869411,
-0.016726747,
0.022922324,
-0.0070076818,
-0.043355938,
0.022476977,
0.029157197,
-0.008487809,
-0.029235788,
0.014892962,
-0.0031845658,
-0.0035660588,
-0.013845084,
0.0072958483,
0.013740296,
-0.027899744,
-0.02132431,
0.003117436,
0.02415358,
0.012417351,
-0.02235909,
-0.016176611,
-0.009895895,
-0.0033695817,
0.0038280282,
-0.019058276,
0.016779142,
-0.015809854,
-0.035077706,
-0.0064280746,
-0.025384836,
0.019804887,
0.0023790097,
-0.005442415,
0.031043377,
0.0054096687,
-0.0091885775,
0.032536604,
-0.013609312,
0.019713199,
-0.020944456,
0.016936323,
-0.007505424,
0.023197392,
-0.020525305,
-0.0009430899,
0.015953938,
-0.036439948,
0.015482393,
-0.017866313,
-0.020355023,
0.019752495,
-0.0082192905,
-0.018639125,
0.032012664,
0.021271916,
0.0132753,
0.024101187,
0.016294498,
0.008579498,
-0.03984555,
0.020603895,
-0.005953255,
-0.042019896,
0.042832,
0.015495491,
-0.015325211,
-0.0086318925,
0.015416901,
-0.0053409017,
-0.013137766,
0.0102822995,
0.019844184,
0.012155381,
-0.008795624,
-0.00009849436,
0.00068398577,
0.011932707,
-0.041941304,
0.077019006,
-0.0037592612,
0.003079778,
-0.012207774,
0.016713649,
-0.01567887,
0.0063953283,
0.0057731513,
-0.0021612477,
0.01275791,
-0.015744362,
0.019647706,
0.0045680916,
0.008383022,
0.0059990995,
0.001587371,
-0.028214106,
0.024703717,
0.003079778,
-0.0059663537,
-0.014028463,
0.02175656,
0.02005376,
-0.01499775,
-0.00079491345,
-0.03271998,
0.010190611,
-0.021625575,
-0.02381302,
-0.0042340807,
0.0032877163,
0.004345418,
0.007498875,
0.0070797238,
-0.012482842,
0.020381222,
-0.021455295,
-0.023773724,
0.017434064,
-0.009109987,
-0.00271957,
0.0076036626,
0.005150974,
-0.008468161,
-0.016923225,
0.015560984,
0.0014277333,
-0.009915543,
-0.018927291,
-0.03657093,
-0.013072274,
-0.009352309,
0.0035660588,
0.03135774,
-0.028790439,
-0.012443547,
-0.029392969,
-0.0046466826,
0.01139567,
-0.038326126,
-0.0044240085,
0.021795856,
-0.023747528,
0.0009095251,
0.0013737022,
-0.16336413,
-0.0100072315,
0.0032189493,
-0.025240753,
0.031960268,
0.023459362,
0.027768759,
-0.016229006,
-0.01635999,
0.033034343,
0.022581764,
0.0057109334,
-0.05857636,
-0.0064280746,
0.015403802,
-0.0020597347,
-0.018770108,
0.034029827,
0.024101187,
-0.016373089,
0.017604345,
-0.019817986,
0.032169845,
-0.009751812,
0.0029749903,
0.01731618,
0.017028011,
0.009647024,
-0.018887995,
-0.02243768,
-0.008723581,
0.001205878,
0.015233521,
0.00090706913,
0.0019205633,
-0.003058493,
0.008723581,
-0.0027588655,
0.0067457124,
-0.009378505,
0.0299955,
0.02304021,
-0.00085467525,
0.0061006127,
-0.016883928,
0.037042476,
0.017198293,
-0.015744362,
0.0098762475,
0.011159897,
0.02758538,
0.003494017,
-0.0012435361,
0.007891829,
0.019294048,
-0.0072762007,
0.011873764,
0.0007625766,
0.006804656,
-0.0055472027,
-0.0058877626,
-0.011212291,
0.04508494,
0.0024363156,
-0.00993519,
-0.04233426,
-0.025411034,
0.025332443,
-0.036046993,
-0.00075111544,
0.0014572049,
0.0030142856,
0.008350275,
-0.024821602,
0.018154481,
0.0055144564,
-0.0040507023,
0.015953938,
-0.0068308525,
-0.0039262665,
-0.020525305,
0.010243004,
-0.025686102,
-0.01824617,
-0.015390703,
0.0007236905,
-0.0041423915,
0.011415318,
-0.008507457,
-0.011415318,
0.0002621741,
-0.026642289,
0.007839435,
-0.018364057,
0.024520338,
0.015325211,
0.014251136,
-0.0032975401,
-0.0064804684,
-0.014788174,
0.0025034454,
-0.010478777,
-0.015901543,
0.028580863,
0.03219604,
-0.014473811,
-0.002380647,
0.0043028477,
0.04482297,
-0.00582227,
-0.027192425,
0.0021858073,
-0.014879863,
0.015325211,
0.001876356,
0.010727648,
-0.02192684,
0.020289531,
-0.010039978,
-0.0029668037,
0.07219877,
-0.00077240047,
-0.007171413,
0.017918708,
-0.0064640953,
-0.02450724,
-0.14062518,
-0.011028913,
-0.012921642,
-0.0076888027,
-0.00531143,
0.023380771,
-0.0017306355,
0.02106234,
-0.03214365,
0.03400363,
-0.013144315,
-0.0188487,
-0.0068832464,
-0.018442648,
0.01490606,
0.002650803,
0.004162039,
0.0047973148,
-0.042701013,
0.03675431,
0.0016978893,
0.01139567,
-0.014526204,
-0.034213208,
0.02279134,
0.00064428104,
-0.045766056,
0.025293147,
0.011231938,
0.005877939,
-0.0074923253,
-0.023564149,
-0.000579198,
-0.0046663303,
-0.02766397,
0.012070241,
-0.0036970435,
-0.023944005,
0.030283665,
-0.021625575,
-0.0076888027,
0.011710033,
0.012155381,
-0.0061006127,
0.018219974,
-0.025528919,
-0.020079955,
0.0188487,
0.009214775,
-0.0059401565,
-0.019045176,
-0.0131901605,
-0.019516721,
-0.006097338,
0.002613145,
-0.025673004,
-0.001049515,
0.014853666,
-0.014172546,
0.0058026225,
-0.009863148,
-0.015744362,
-0.01156595,
0.0031927524,
0.013570016,
-0.028423682,
0.009345759,
0.0039819353,
0.021651773,
-0.022634158,
-0.005576674,
-0.015521688,
-0.012430449,
0.007918025,
-0.022267401,
-0.0010200434,
-0.0016135679,
0.0007633953,
0.005740405,
-0.0053245286,
-0.009457096,
-0.0077084503,
0.016464777,
0.002369186,
0.035732627,
0.006785008,
-0.013661705,
0.0084943585,
-0.011428416,
-0.0047089,
-0.0017863039,
0.035627842,
-0.008055559,
-0.03177689,
-0.021271916,
-0.0001203422,
0.0058550164,
-0.017669838,
0.020171646,
0.028056925,
0.0070469775,
-0.011264685,
-0.061458025,
0.010799689,
-0.0011674012,
0.0027997983,
0.016215907,
-0.0101447655,
0.016425483,
-0.0016635058,
-0.00087923487,
0.04084103,
-0.013386637,
0.022463877,
-0.024284566,
-0.004633584,
-0.035680234,
-0.008428866,
0.03127915,
0.0037887327,
0.0026835492,
0.028659454,
0.0037559865,
0.005370373,
0.0006311826,
-0.0038967952,
-0.0068832464,
-0.014539302,
0.006837402,
0.015718166,
-0.022070924,
-0.020852765,
0.020355023,
-0.0376712,
-0.0051116785,
0.0041096453,
-0.012607278,
-0.0033286489,
0.0012607279,
0.023682036,
0.02818791,
0.053913306,
-0.020970652,
-0.02724482,
0.010373989,
0.025397936,
-0.001653682,
-0.004053977,
-0.03989794,
0.024598928,
0.0046892525,
-0.004748196,
0.031069573,
0.012685869,
0.0032959029,
-0.01917616,
-0.00013814794,
0.00064591836,
0.0006631101,
0.004951222,
-0.008540203,
-0.002888213,
0.017918708,
0.02535864,
0.0034317994,
0.0065328623,
-0.031148164,
-0.0001515534,
-0.029864514,
-0.014984651,
-0.004024505,
-0.024363156,
-0.009751812,
0.011362923,
-0.0017208116,
0.01979179,
-0.014657189,
-0.00012914273,
-0.00042815626,
0.008284783,
-0.023760626,
0.010668704,
0.0045156977,
-0.019896578,
0.0037199657,
0.005884488,
0.043224953,
-0.004685978,
-0.002316792,
0.0017781174,
0.008206192,
0.010387087,
0.00147849,
0.017486459,
0.03279857,
0.02962874,
0.003186203,
0.02116713,
-0.0002850964,
0.020420516,
0.0067784586,
0.03735684,
0.016975619,
0.0037920072,
0.023053309,
-0.027768759,
-0.01293474,
0.02818791,
-0.019464327,
-0.039609775,
-0.0076364083,
0.022110218,
0.03725205,
0.013294948,
-0.001871444,
0.003562784,
-0.0064542717,
0.01601943,
-0.0030241094,
0.0046073874,
-0.02039432,
0.038640488,
0.014709583,
0.015731264,
0.012581081,
0.013936773,
0.026825668,
0.0040572514,
0.0064280746,
-0.00024989428,
0.014539302,
-0.01670055,
0.0062676184,
-0.018979684,
-0.0091885775,
-0.023066407,
-0.011493908,
-0.009149282,
0.018259268,
0.017656738,
-0.007374439,
0.07424213,
0.021232622,
-0.0091820285,
0.0032402342,
-0.05076967,
0.022922324,
0.04042188,
0.0018829051,
-0.0023871963,
-0.013753395,
0.028973818,
-0.027821152,
0.021350507,
-0.041260183,
-0.037487824,
0.04249144,
0.0091754785,
0.02158628,
-0.005576674,
-0.0029815394,
0.0066278265,
-0.014041561,
0.00950949,
0.007308947,
-0.020603895,
0.005943431,
0.017866313,
-0.021913743,
-0.008540203,
-0.0239833,
0.0003452675,
-0.009620827,
-0.017080406,
0.009902444,
0.023184294,
-0.025384836,
-0.0028702025,
-0.039714564,
0.020747978,
0.012129184,
-0.0075250715,
0.0071124695,
0.0072434545,
-0.032012664,
0.006310188,
-0.013858182,
-0.025607511,
-0.01653027,
0.0123584075
] |
Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or "niche" influences stem cell fate decisions, few signals that emanate from the niche to specify stem cell self-renewal have been identified. Here we demonstrate that the apical hub cells in the Drosophila testis act as a cellular niche that supports stem cell self-renewal. Hub cells express the ligand Unpaired (Upd), which activates | [
0.0011006754,
0.0033011993,
-0.011848593,
-0.022982698,
-0.013694353,
0.011266418,
-0.012907093,
0.033580936,
-0.018563457,
-0.027018232,
0.016089212,
0.00070001633,
-0.0074756616,
0.005610054,
-0.013985441,
-0.00020136323,
0.03141101,
0.006202153,
0.001393417,
0.0062815407,
-0.030643597,
0.012013984,
-0.0054115853,
-0.020018896,
0.0007397101,
0.024610143,
0.008534162,
-0.023234092,
0.0056199776,
-0.02688592,
0.010677626,
0.0076807463,
-0.013198182,
-0.016525844,
-0.011372267,
0.018709002,
-0.007938756,
-0.011583968,
0.015414418,
0.006939796,
0.014025135,
0.009043566,
-0.0061591514,
-0.0092883445,
-0.011213493,
0.007925524,
-0.01501748,
-0.0018920702,
-0.01348927,
0.026700683,
0.016631693,
-0.016049517,
-0.040196568,
-0.00096918974,
-0.033025224,
-0.009116338,
0.009691898,
0.0036981371,
0.0004651615,
0.0017878739,
-0.0044754734,
0.0041513075,
-0.00955297,
0.012404306,
-0.00940081,
0.007991681,
-0.007905678,
0.0132908,
0.0136149665,
0.0017283333,
0.028394284,
-0.003486437,
0.00604007,
-0.0059408355,
-0.0061227656,
-0.024292592,
-0.018867776,
0.0002807508,
0.0013256068,
0.0128277065,
0.020534916,
-0.03456005,
-0.018245908,
0.021566954,
0.023882424,
0.00078684645,
0.005199885,
0.010227764,
0.013985441,
-0.0020409217,
0.011147336,
0.016009824,
0.018669307,
0.006152536,
-0.000074425836,
0.0071250335,
0.010843017,
0.019264715,
-0.007667515,
-0.034904063,
-0.02656837,
0.020362908,
0.0021186555,
-0.022744535,
-0.03088176,
0.019820428,
0.02038937,
-0.019516109,
0.02603912,
0.009036951,
-0.027229933,
0.020349678,
-0.0021600032,
-0.05493619,
0.024821844,
-0.0039594546,
0.004111614,
0.015718736,
-0.02603912,
0.0025189011,
0.034163114,
0.024305824,
0.025364324,
-0.027970882,
0.012371228,
0.03948208,
-0.006036762,
-0.00007096297,
-0.025351094,
-0.0008265402,
-0.0021666188,
-0.011961059,
-0.007998296,
0.031860873,
-0.018722232,
-0.01881485,
-0.017769583,
-0.0014604003,
-0.0075484337,
-0.035962563,
-0.0095926635,
0.04077874,
-0.02300916,
0.008904638,
0.0126953935,
-0.0071581113,
0.04472166,
-0.00855401,
0.016896319,
0.016049517,
0.013429728,
-0.020852465,
0.024504293,
-0.014951323,
0.00013562042,
0.017571112,
0.0049617225,
0.024133818,
-0.020971546,
0.0046937894,
0.009605895,
-0.009301576,
0.025721569,
-0.01176259,
0.010962099,
0.021196477,
0.0072904243,
0.030722985,
0.0018259138,
-0.010836402,
0.0031242312,
0.018761925,
-0.028870609,
0.004022303,
-0.028394284,
0.01712125,
-0.005345429,
0.011497965,
-0.02320763,
-0.03141101,
0.005163499,
0.008163687,
0.0078858305,
0.035009913,
-0.014130985,
-0.0052461945,
0.009427273,
-0.015798124,
-0.01354881,
0.005180038,
-0.020561378,
0.006450239,
0.00056770374,
-0.006506472,
-0.63637066,
-0.012179375,
0.020839235,
-0.011841977,
0.031384546,
0.025152626,
-0.00048335447,
0.0032929298,
-0.024715994,
-0.010373307,
-0.005848217,
-0.005768829,
-0.004217464,
0.0028910302,
-0.016618462,
-0.022956235,
-0.00661563,
-0.011597199,
0.004187694,
-0.008335694,
0.0011056372,
0.0052858884,
-0.02363103,
0.017213868,
0.003913145,
0.021262635,
0.030193735,
0.002074,
-0.018351758,
0.0027008308,
-0.02720347,
0.007449199,
-0.01563935,
0.0070919553,
0.04882335,
0.022916542,
-0.014448536,
0.010088836,
-0.0075748963,
0.044404108,
-0.011888287,
-0.00066321687,
0.0065924753,
-0.013317263,
-0.016843393,
-0.0031540014,
-0.019674882,
0.0046937894,
-0.0015240757,
0.004971646,
0.010088836,
-0.0019896508,
-0.03143747,
0.0017845661,
0.010254227,
0.00059085846,
0.013026175,
-0.002178196,
-0.0039958404,
0.016869856,
-0.00682733,
0.031702098,
-0.017835738,
-0.002236083,
0.0024709378,
0.03979963,
-0.029399859,
-0.00032127154,
0.011841977,
-0.026912382,
-0.00336074,
0.029135235,
-0.024729224,
0.001232988,
0.013601735,
0.02490123,
0.0029406475,
0.0026330207,
-0.006046686,
0.0064932406,
0.012066909,
-0.016764006,
-0.010723936,
0.006595783,
0.023908887,
-0.0094603505,
-0.011603815,
0.013211412,
-0.021474335,
0.018325295,
0.017518187,
0.02225498,
0.0006239366,
-0.055782992,
-0.010121914,
0.020984778,
-0.016195063,
0.005788676,
-0.008236459,
-0.043345608,
-0.005467818,
0.0064270846,
0.015414418,
0.0061988453,
0.011802284,
-0.001840799,
-0.020098284,
0.012278609,
0.028209046,
-0.027494557,
0.010565161,
-0.0013892823,
-0.018669307,
0.0023154705,
-0.013906054,
-0.018364988,
0.012219069,
0.011570737,
0.009367731,
-0.022188822,
0.004915413,
0.004700405,
0.006860408,
-0.008593704,
0.02478215,
0.0050477255,
0.0041711545,
-0.006595783,
-0.012404306,
-0.010637932,
-0.008732632,
-0.018047439,
0.028764758,
-0.023181166,
0.03321046,
0.0020227288,
0.0015215948,
0.0030283045,
0.031569786,
-0.03035251,
-0.030378973,
-0.008699553,
0.012265378,
-0.025271706,
-0.017901894,
-0.011266418,
-0.02826197,
-0.012682162,
0.013032791,
-0.028553057,
-0.009261882,
0.0040355343,
-0.027706258,
0.006238539,
0.008388619,
-0.003253236,
0.0012635853,
-0.007058877,
0.009096491,
-0.011703049,
-0.013681122,
0.022744535,
-0.015189487,
0.0050278786,
-0.0355127,
-0.00077154784,
-0.018312063,
0.0018391451,
0.008997257,
-0.03781494,
0.007859368,
-0.01250354,
-0.0033756252,
0.014276529,
-0.016406761,
-0.01071732,
-0.023723649,
0.017385876,
-0.018709002,
-0.0019879967,
-0.020495221,
-0.033951413,
-0.00014347647,
-0.017266793,
0.04252527,
0.0111208735,
0.048982125,
0.020852465,
0.010452695,
0.022546066,
-0.010512236,
0.011147336,
-0.004627633,
0.014263298,
0.0025139393,
-0.025827419,
0.018629614,
0.023922117,
-0.010135145,
0.015679043,
-0.0022112743,
-0.03244305,
0.00008512455,
-0.02961156,
0.010452695,
-0.012463846,
-0.003790756,
-0.0023088548,
0.021103859,
0.015943669,
0.019529339,
0.015692273,
-0.024557218,
0.0027438325,
0.013191566,
0.011107642,
0.002378319,
-0.0012205837,
0.004220772,
0.009380963,
-0.008190149,
-0.009321422,
-0.00014233941,
-0.004220772,
0.0035625168,
0.017041862,
-0.0025040158,
0.0077799805,
0.0016911203,
-0.01566581,
0.015930437,
0.016419994,
0.0040950747,
0.0028132966,
0.01333711,
0.024543988,
0.00027847665,
-0.008580472,
0.022678379,
-0.01365466,
0.0017762966,
0.012490309,
0.008527547,
-0.009103106,
0.010829786,
-0.02300916,
0.041731395,
-0.005447971,
-0.024491062,
0.011233339,
-0.01911917,
0.004277005,
-0.005024571,
-0.012013984,
0.0143559165,
-0.013892823,
0.01203383,
-0.00057101157,
0.02773272,
0.0056398246,
0.0114251925,
-0.012179375,
0.00076038396,
-0.0321255,
-0.0018490686,
-0.00086251274,
0.015943669,
-0.016102443,
-0.02459691,
-0.005474434,
-0.011048102,
0.00357244,
0.014977786,
-0.02697854,
0.0059044496,
0.013628198,
0.009863904,
0.0014248412,
0.003717984,
0.0103799235,
0.0039362996,
-0.008408465,
0.039085142,
0.018775158,
0.00015371002,
-0.012417537,
-0.009619126,
-0.008223228,
0.0026230973,
0.0041744625,
0.0056001307,
0.006556089,
0.012682162,
0.010803323,
-0.011531043,
-0.022691611,
-0.00059623364,
-0.018828083,
0.020045359,
-0.013813435,
0.0017018708,
-0.0003055594,
-0.010201301,
-0.0003861874,
0.014832242,
-0.0042141564,
0.0026049044,
-0.015877511,
-0.006165767,
-0.027229933,
-0.026277281,
-0.033369236,
-0.012490309,
-0.013052638,
0.011054717,
-0.011372267,
0.01460731,
-0.00604007,
0.012807859,
-0.0031159616,
-0.02971741,
-0.007025799,
-0.009056797,
-0.0023154705,
0.04075228,
0.029532172,
-0.0019416873,
0.031358086,
-0.009070029,
-0.01276155,
0.009268497,
0.0068736393,
0.012622622,
-0.026436057,
0.0032085804,
-0.012391075,
0.00050526875,
-0.005001416,
0.025999425,
0.024927692,
-0.029982034,
-0.011980905,
-0.016764006,
-0.0043530846,
0.018444376,
0.004257158,
0.0011883326,
0.033263385,
0.032204885,
0.01034023,
0.0035658246,
0.00703903,
-0.0039164526,
0.0067082485,
-0.013985441,
0.012086756,
0.0012776435,
0.037047528,
0.010730552,
-0.037656166,
-0.0051171896,
0.004650788,
-0.005454587,
-0.0011759282,
0.019886583,
-0.0042935438,
0.013171719,
-0.0032218117,
-0.003397126,
-0.00091957254,
0.022453448,
-0.007197805,
-0.016221525,
-0.0350893,
0.027005002,
-0.032839987,
-0.010207917,
-0.014064829,
0.015851049,
0.014633773,
0.0077799805,
-0.017412338,
-0.0106842425,
-0.014501461,
-0.009665435,
-0.014461767,
0.014064829,
0.000024395134,
-0.014236836,
-0.0013917631,
-0.000048997008,
-0.010280689,
-0.033104613,
-0.018947164,
0.021461103,
-0.014236836,
-0.045118596,
0.0014711507,
-0.011861824,
0.028500134,
0.013773741,
-0.0028463746,
-0.018536994,
0.0312787,
0.0155334985,
-0.030855298,
-0.006635477,
-0.024649836,
0.014951323,
0.02028352,
-0.00797845,
-0.012225684,
-0.017372644,
-0.015321799,
0.016618462,
0.0029274162,
-0.009473582,
0.00012580033,
-0.016353836,
0.01858992,
0.045753695,
0.0038469888,
-0.01203383,
-0.0024064353,
-0.010631317,
-0.04181078,
-0.028658908,
0.0012007368,
-0.009837441,
-0.014461767,
-0.010068988,
0.011332574,
-0.013528963,
-0.012688778,
0.023789804,
-0.003362394,
0.0018424529,
-0.006648708,
0.008229843,
-0.0024411674,
-0.008845097,
-0.0023088548,
-0.005682826,
0.0100292945,
-0.004521783,
-0.035671476,
0.016300911,
0.006162459,
-0.025695106,
-0.00021500797,
0.0008224055,
-0.014223604,
-0.022400523,
0.0020425757,
0.010677626,
0.031649172,
-0.01512333,
-0.036968138,
-0.004627633,
-0.022823922,
-0.0093743475,
-0.00029873702,
0.0033359313,
-0.027573945,
-0.010776861,
0.011220108,
0.0018920702,
-0.023750111,
0.02720347,
-0.03432189,
0.000009245085,
0.02921462,
0.0170154,
-0.005361968,
-0.017160945,
0.0025519792,
-0.00041988576,
-0.012371228,
-0.001413264,
-0.017954819,
0.018536994,
-0.02541725,
0.034983452,
0.02553633,
0.034851138,
0.013720816,
0.0255231,
0.021527259,
0.00714488,
0.0038370653,
-0.0005486838,
0.025774494,
-0.017835738,
0.018153287,
-0.010783477,
0.006377467,
0.019238252,
-0.0018242599,
-0.0013462807,
0.043001592,
-0.003091153,
-0.0013859745,
0.012457231,
-0.043848395,
-0.030405434,
0.022731304,
-0.037973717,
0.0015257297,
-0.022281442,
-0.00085010845,
-0.0023717033,
0.0040487656,
-0.017703425,
-0.0047070207,
0.02195066,
-0.010095451,
0.033157535,
-0.007832905,
0.004601171,
-0.025695106,
-0.004452319,
-0.0026925614,
-0.026740376,
0.013462807,
-0.007277193,
-0.0027636793,
0.016777238,
-0.023366405,
0.009685282,
0.01460731,
-0.019397026,
-0.03268121,
-0.001733295,
-0.028500134,
-0.010618086,
-0.019158864,
-0.028553057,
-0.010942251,
-0.013052638,
-0.0075153555,
-0.00443578,
0.03056421,
-0.010637932,
-0.007945372,
0.034268964,
-0.009003872,
0.020733384,
-0.029055847,
0.012053678,
0.039005753,
-0.00031734348,
-0.015215948,
-0.012926941,
-0.026277281,
-0.0035327463,
0.04138738,
0.021778654,
0.001535653,
-0.02331348,
0.017557882,
0.009936676,
0.0030415358,
-0.035803787,
0.010009448,
-0.009566201,
-0.0034070495,
-0.00682733,
0.0052825804,
-0.015864281,
0.0033359313,
0.0037444464,
0.005348737,
0.0004345642,
-0.0043365452,
-0.016737543,
0.023273787,
-0.0030150732,
0.018933933,
0.0077336715,
-0.003893298,
-0.0153614925,
-0.015731968,
-0.019727807,
0.006546166,
-0.0030464975,
0.019132402,
-0.017372644,
0.0019582263,
0.022559298,
-0.001250354,
-0.011325958,
0.0054578944,
0.00086416665,
0.039190993,
-0.014554386,
-0.0062980796,
0.007879215,
0.008044606,
-0.0005718385,
-0.020296752,
-0.007872599,
0.022440216,
-0.034057263,
-0.020773077,
0.03307815,
0.008461391,
0.011438424,
-0.012404306,
-0.032945838,
-0.013720816,
-0.03088176,
-0.016737543,
0.01065778,
-0.041096292,
-0.0027223318,
0.0122124525,
0.034983452,
0.0047434065,
0.008057837,
-0.0077998275,
-0.012735087,
0.028235508,
-0.014991017,
0.020984778,
0.008494468,
0.0045714,
-0.025827419,
0.012814475,
0.019555802,
-0.03056421,
0.00682733,
-0.033157535,
-0.010704089,
0.018603152,
0.006880255,
0.020534916,
-0.0058515244,
-0.006754558,
-0.012073524,
0.02300916,
0.016234756,
-0.005269349,
-0.017425569,
0.006215384,
-0.021143554,
-0.012199221,
0.012457231,
-0.024332287,
-0.008547394,
0.0055868994,
0.011220108,
0.018576689,
-0.025496637,
-0.007852753,
-0.016115675,
-0.010518852,
0.010591623,
0.00018658144,
-0.015004248,
-0.00961251,
-0.023366405,
0.022096204,
-0.01606275,
0.0013264337,
-0.0016563883,
0.008031375,
0.028553057,
0.0131320255,
0.000019213752,
0.017438801,
0.0010973676,
-0.03067006,
-0.03342216,
0.02299593,
-0.010796708,
0.039085142,
0.013237875,
-0.01344296,
-0.019304408,
0.00940081,
-0.03855589,
-0.041122757,
0.030061422,
0.004925336,
-0.009784517,
0.007323502,
-0.007521971,
-0.021791885,
0.003751062,
0.0129137095,
-0.008130609,
-0.017676963,
0.035353925,
0.015387955,
-0.0033193922,
0.013601735,
-0.020217365,
-0.016300911,
0.018073902,
-0.013747279,
-0.0064733936,
0.017425569,
-0.014011904,
0.03342216,
0.0029456092,
0.041546155,
0.020878928,
0.04488043,
0.009103106,
-0.008329078,
-0.00019123305,
0.0050510336,
-0.012834322,
-0.015824586,
-0.0051006507,
-0.010783477,
0.011438424,
0.009731592,
-0.011464886,
-0.008633397,
0.0076542837,
0.0038866824,
0.039958403,
-0.006344389,
0.015837818,
0.011061333,
0.015864281,
-0.005292504,
-0.008666475,
0.0066222455,
-0.025073238,
-0.009466967,
-0.008712784,
-0.016314143,
-0.0064039296,
-0.016380299,
-0.007859368,
-0.031146385,
0.009665435,
0.0010113644,
-0.018775158,
-0.029002922,
0.034718826,
-0.006489933,
-0.0065494734,
0.0023865884,
0.009910214,
-0.0022294673,
-0.024715994,
0.0053355056,
0.0057059806,
-0.016049517,
0.01660523,
-0.013535579,
-0.0029571864,
-0.008296,
0.008600319,
-0.0028529903,
-0.011325958,
0.007958603,
0.20471404,
-0.01660523,
0.010115298,
-0.0029621483,
0.024319055,
-0.0077799805,
0.0017961435,
-0.015811356,
0.0058151386,
-0.014302991,
0.0056596715,
0.019383796,
-0.0006115323,
0.0020111515,
0.034004338,
-0.02826197,
-0.009903598,
-0.010062373,
-0.014170679,
-0.0152291795,
0.010313767,
-0.012582928,
0.012371228,
0.0004200925,
0.05091389,
-0.009169263,
-0.037550315,
-0.023763342,
0.021566954,
0.006222,
-0.028817683,
0.00089972565,
-0.0057820603,
0.005643132,
0.03990548,
0.0017068326,
-0.0013380111,
0.017729888,
0.019767502,
0.003450051,
0.028870609,
-0.0021732345,
0.0076741306,
0.009228803,
0.011617046,
0.042207718,
-0.00013117553,
-0.012099987,
0.0028347974,
-0.013006329,
-0.04231357,
0.0055306666,
0.01575843,
0.0026743684,
-0.016962474,
0.0102476105,
0.011239955,
0.0091560315,
0.0035360542,
0.028447209,
-0.018457606,
0.020878928,
-0.028605983,
0.019370563,
-0.019397026,
0.0040156874,
-0.024570448,
0.014633773,
0.030273123,
-0.006913333,
0.0062980796,
-0.009857289,
-0.021289097,
-0.0021947352,
0.0015108444,
-0.030696522,
0.01297325,
-0.009275113,
0.0052230395,
0.010704089,
0.035248075,
0.0056001307,
-0.026753606,
0.0029555326,
0.001609252,
-0.026422825,
0.009619126,
0.012946787,
-0.02950571,
-0.022969468,
0.009076644,
-0.009202342,
0.0079321405,
0.0019069553,
0.0030795757,
-0.013562041,
0.00965882,
0.012874016,
0.0035426698,
-0.027706258,
-0.03201965,
0.055941764,
0.020124746,
0.025126163,
0.008884791,
0.018947164,
0.007323502,
0.027468095,
-0.020574609,
-0.020243827,
0.01911917,
-0.03350155,
0.007899062,
-0.004776485,
-0.0024742456,
0.008567241,
0.009208957,
-0.02396181,
0.049299672,
-0.013853129,
-0.0076939776,
-0.010227764,
0.0033557783,
0.03937623,
-0.0070853396,
-0.0014661889,
-0.011478118,
0.0026363286,
-0.008593704,
-0.02950571,
0.0028447208,
-0.013495885,
-0.01171628,
0.0028298358,
0.023683954,
-0.018947164,
-0.0016572153,
-0.023776574,
-0.023260554,
0.007257346,
-0.0036253652,
-0.007806443,
0.023511948,
0.017941589,
-0.003555901,
-0.014091291,
0.031172847,
0.022082973,
0.0012710278,
-0.020071821,
0.0016671388,
-0.02394858,
-0.01931764,
0.0030613828,
0.0047103283,
-0.0118221305,
-0.015983362,
-0.013773741,
0.0045647845,
-0.0033491626,
-0.022043278,
0.0061756903,
-0.01333711,
-0.00929496,
0.00046061323,
-0.016221525,
-0.16576122,
0.008798787,
0.03961439,
-0.026330207,
0.023075316,
0.022387292,
-0.0028662216,
-0.0020028818,
-0.0017481801,
0.022757767,
0.035777327,
0.002646252,
-0.032919373,
-0.014329454,
0.041546155,
0.017769583,
0.018351758,
0.04450996,
0.022069741,
0.013985441,
0.02142141,
-0.015043942,
0.016843393,
0.007237499,
0.01034023,
-0.018761925,
0.002910877,
-0.0074624303,
-0.0061558434,
-0.025695106,
0.0018126826,
0.009003872,
0.02868537,
-0.015626118,
0.013667891,
0.0016514265,
-0.00022245056,
-0.0020971547,
0.015996592,
0.032839987,
0.0052660415,
0.010618086,
-0.0032102345,
0.00971836,
0.0057622134,
0.0350893,
-0.023406098,
-0.00082984805,
0.015837818,
-0.023339942,
0.029373396,
-0.00060160883,
-0.0026214432,
0.01533503,
0.023908887,
0.010849633,
0.00070745894,
0.029743873,
0.0027124083,
-0.005150268,
0.016142137,
0.002482515,
0.023723649,
0.00908326,
-0.0035062837,
-0.013800204,
0.01229184,
0.02132879,
-0.021924198,
0.018312063,
-0.008911253,
-0.0039396076,
0.01712125,
-0.0071713426,
0.025827419,
0.011669971,
0.0056166695,
-0.0073367334,
-0.01034023,
0.012688778,
-0.020826003,
0.029638022,
-0.014924861,
-0.029585097,
-0.01607598,
0.016102443,
-0.0022741228,
0.018761925,
-0.005414893,
-0.013423113,
0.020124746,
-0.03331631,
-0.024768919,
-0.0036319809,
0.015242411,
0.02196389,
-0.011392115,
-0.020839235,
0.0021037704,
0.0065031643,
0.0048029474,
0.004167847,
-0.013118794,
0.008064453,
0.031119922,
0.012860784,
-0.019132402,
0.005848217,
0.057847068,
-0.012926941,
0.014951323,
-0.00703903,
0.0050146473,
0.009566201,
0.0014083022,
0.038185414,
0.00096670893,
-0.000983248,
0.004247234,
-0.041043367,
0.06642092,
0.007058877,
-0.008858329,
0.033977874,
0.024808612,
-0.025232011,
-0.1456497,
-0.01407806,
0.0024527449,
0.014316223,
-0.017491726,
0.024543988,
-0.011888287,
0.017690195,
-0.012166143,
0.014580849,
-0.023260554,
-0.029982034,
-0.007647668,
-0.027335782,
-0.0023518563,
-0.018245908,
0.011703049,
-0.008858329,
-0.020111514,
0.024610143,
0.014991017,
-0.008150456,
-0.025999425,
-0.0031209234,
0.006400622,
0.026647758,
-0.039561465,
0.030167272,
0.03707399,
0.005229655,
-0.011755974,
-0.0094603505,
0.021077396,
0.001626618,
-0.0130791,
-0.007561665,
0.008044606,
-0.028870609,
0.034956988,
-0.02971741,
-0.0042273873,
0.019039782,
0.03201965,
-0.011015024,
-0.006076456,
-0.007647668,
0.0024775534,
0.004640864,
0.005004724,
-0.017915126,
-0.05398354,
0.0029009536,
-0.027044695,
-0.0114715025,
0.018629614,
-0.007078724,
0.01921179,
-0.005004724,
0.019251483,
-0.016247988,
-0.0057952916,
0.021514028,
-0.029055847,
-0.011378883,
0.020852465,
-0.021686034,
-0.049352597,
-0.031569786,
0.030484822,
-0.028817683,
0.00386022,
-0.020759847,
-0.0006950546,
0.015295336,
-0.012616006,
0.0041248454,
-0.004270389,
-0.0046044784,
-0.013958979,
-0.009533122,
-0.011259802,
-0.017504957,
-0.0003055594,
-0.019383796,
0.020521684,
-0.008229843,
0.022215284,
-0.0052461945,
0.013277569,
-0.009989601,
-0.0030828835,
0.029929109,
-0.0098109795,
-0.030934686,
-0.0061955373,
0.0073698116,
0.0064733936,
-0.0016390223,
0.021566954,
0.012754934,
-0.027150545,
-0.0059739137,
-0.047103286,
0.01460731,
-0.008580472,
0.016353836,
-0.0055141277,
-0.03948208,
0.007846137,
-0.01881485,
-0.008421697,
0.015215948,
-0.00080545293,
0.008137224,
-0.010968714,
-0.004591247,
-0.021461103,
-0.030696522,
0.011987521,
-0.020601071,
0.0028099888,
0.029770335,
0.002178196,
-0.017174175,
-0.00063882174,
-0.0073168864,
-0.010320382,
0.0026875995,
-0.0033822407,
0.025972962,
0.0075947433,
-0.013839898,
0.015890744,
-0.04927321,
-0.019793965,
0.0033640477,
-0.0076212054,
-0.0018937241,
-0.0129137095,
0.015189487,
0.01837822,
0.017041862,
-0.015255642,
-0.039984867,
0.010763629,
-0.0028116426,
-0.024001505,
0.021408178,
-0.032548897,
0.004640864,
0.008421697,
-0.018404683,
0.05117851,
0.006112842,
0.006919949,
-0.035539165,
-0.0049220286,
-0.020098284,
-0.0030266508,
0.0036253652,
-0.011160567,
0.0072904243,
0.001447996,
0.035565626,
0.022598991,
0.014038366,
-0.009466967,
-0.015321799,
-0.028870609,
-0.004472166,
-0.0055008964,
-0.01397221,
-0.025324631,
-0.005576976,
0.014302991,
0.0043597003,
0.030484822,
-0.0005784541,
-0.009857289,
0.0025767877,
-0.04040827,
0.028897071,
-0.00014264951,
0.012926941,
-0.0023568182,
0.01671108,
0.023551643,
0.011755974,
-0.01197429,
0.022043278,
0.002037614,
-0.024438137,
-0.013906054,
0.015943669,
0.011630277,
0.006972874,
0.009208957,
0.018563457,
-0.021805115,
0.013065869,
-0.008580472,
0.017504957,
0.003519515,
0.009877135,
0.028923534,
-0.01775635,
0.012324918,
0.025430482,
-0.019026551,
-0.023075316,
-0.008342309,
0.0021070782,
0.0022096203,
0.011610431,
-0.0057655214,
0.002378319,
-0.016922781,
0.014329454,
-0.0130460225,
-0.009109722,
-0.001519114,
0.014832242,
0.017968051,
0.013853129,
-0.0020706921,
-0.003989225,
0.014144217,
0.0008509354,
0.009361116,
-0.015679043,
0.04075228,
-0.009089875,
0.028288433,
0.012113218,
-0.034163114,
-0.01480578,
-0.007991681,
-0.018457606,
0.002826528,
0.029955572,
-0.027362244,
0.08266891,
0.014779317,
-0.036703516,
0.0058184466,
-0.013429728,
0.016009824,
0.0128674,
-0.0028480287,
-0.024239669,
-0.028658908,
0.017174175,
-0.0144882295,
0.03194026,
-0.025800956,
0.010757014,
0.022612223,
-0.021910965,
-0.00084845454,
0.014302991,
-0.0016142137,
0.015586424,
-0.027494557,
0.016195063,
0.022678379,
-0.041996017,
0.011583968,
0.010578392,
-0.018245908,
-0.0007909812,
-0.01763727,
0.023048854,
0.0022575837,
-0.043345608,
0.008428313,
-0.007925524,
0.025324631,
-0.008335694,
-0.016631693,
0.0053917384,
0.01712125,
-0.019926278,
0.003790756,
-0.011835362,
-0.009453735,
0.008481237,
-0.015745198,
-0.009744823,
-0.0024196666,
0.0036749823
] |
OBJECTIVE To evaluate the effects of dietary and lifestyle interventions in pregnancy on maternal and fetal weight and to quantify the effects of these interventions on obstetric outcomes. DESIGN Systematic review and meta-analysis. DATA SOURCES Major databases from inception to January 2012 without language restrictions. STUDY SELECTION Randomised controlled trials that evaluated any dietary or lifestyle interventions with potential to influence maternal weight during pregnancy and outcomes of pregnancy. DATA SYNTHESIS Results summarised as relative risks for dichotomous data and mean differences for continuous data. RESULTS We identified 44 relevant randomised controlled trials (7278 women) evaluating three categories of interventions: diet | [
-0.010423838,
-0.008570567,
0.0030839085,
-0.027909616,
-0.0052867,
0.0100076655,
-0.0004885158,
-0.00039768114,
-0.02868994,
-0.034490354,
-0.0041552293,
0.0029587315,
-0.008642097,
0.026387982,
-0.024424165,
0.010827006,
0.058212228,
-0.0075886585,
-0.011743887,
-0.0051696515,
-0.029548297,
-0.01386377,
-0.011984488,
-0.0046721944,
-0.009643514,
0.013024921,
0.021628002,
-0.033033747,
-0.006730301,
-0.01799949,
0.009532968,
-0.0069448906,
0.00042958505,
-0.02015839,
-0.013089948,
-0.011750391,
-0.0020174647,
0.018844843,
0.0031294273,
-0.01703709,
0.010586406,
0.019820249,
-0.008694119,
0.016529879,
-0.0060442653,
0.004620173,
0.011971482,
-0.015346387,
-0.005029843,
0.014475024,
0.012641261,
0.022876522,
-0.008486032,
0.023214662,
-0.028299779,
0.02630995,
-0.015580485,
0.015411414,
0.01244618,
-0.02902808,
-0.00994914,
0.020990737,
-0.032643586,
-0.0011721128,
-0.0009859728,
0.00011694711,
0.002422258,
0.036363132,
0.012407164,
0.027363388,
0.019091945,
0.028481854,
0.0020337214,
0.010599411,
0.011886947,
-0.02191412,
-0.01862375,
-0.00076528726,
0.018246595,
0.0070684417,
0.010228757,
0.013434592,
0.011555309,
0.029990481,
-0.003111545,
0.0018987902,
-0.009773567,
0.008609584,
0.0061580627,
-0.028793983,
-0.025074435,
-0.0048185056,
0.020548552,
0.016855014,
-0.014956225,
0.01862375,
-0.011938969,
0.025009409,
-0.009194827,
-0.0002040224,
-0.01172438,
0.014123878,
-0.023253677,
-0.004955062,
-0.017310204,
-0.009734551,
-0.026270933,
0.0046786973,
0.007679696,
-0.026374977,
-0.02775355,
0.026413994,
-0.008251934,
-0.030952882,
-0.01720616,
0.0055338033,
0.0051664,
-0.0095719835,
-0.026843172,
0.0031326788,
0.0150082465,
0.010807498,
0.048015982,
0.007107458,
0.020899698,
-0.0020532296,
-0.028611908,
-0.006115795,
-0.02160199,
0.006658771,
-0.0110676065,
0.0070294254,
0.020314455,
-0.0032139625,
-0.039146293,
0.026440004,
-0.0084990375,
-0.0095589785,
-0.021654012,
-0.024020998,
0.007777237,
0.027961638,
-0.02318865,
-0.016789988,
-0.028898027,
0.025126457,
0.024125041,
0.020821666,
-0.015658516,
-0.013798743,
-0.0023816163,
-0.0077837394,
0.01593163,
0.024775311,
0.009780071,
0.008752643,
0.03183725,
0.029262178,
-0.025048425,
-0.017297199,
-0.008076361,
-0.008551059,
-0.019612161,
0.036311112,
0.0062295925,
0.0040284265,
0.0039178804,
-0.022382315,
-0.000018301562,
-0.0041584806,
-0.010384822,
0.021185817,
-0.019235006,
0.002609211,
-0.020314455,
0.00069944735,
-0.006710793,
0.013746722,
0.0033553964,
-0.014670106,
-0.026296945,
0.019169979,
0.022720456,
0.009962146,
-0.01749228,
0.0037130453,
0.017778398,
-0.008401496,
0.0046819486,
-0.023097614,
0.009721546,
0.021614997,
-0.033215825,
-0.008069859,
-0.648814,
0.0002972956,
0.0055403057,
-0.010391325,
0.02390395,
0.01612671,
-0.008720129,
0.015255349,
0.011249682,
0.032981727,
-0.011600828,
0.019521125,
0.008778653,
-0.012511207,
-0.0028709448,
-0.026583064,
-0.006349893,
-0.013285029,
-0.0023052094,
-0.031004904,
-0.01234864,
0.037117448,
0.003137556,
0.018155556,
0.012530715,
0.020236421,
0.0017297199,
0.003839848,
0.0029099612,
0.026101863,
-0.002875822,
0.01006619,
-0.015047262,
0.013128964,
0.047391724,
-0.027831582,
-0.014956225,
0.040030662,
-0.014540051,
0.029418243,
-0.03467243,
-0.028299779,
0.019104952,
0.00992313,
-0.0020451013,
0.026895193,
0.013180986,
-0.0006287304,
0.008973734,
0.002914838,
0.0041389726,
0.01545043,
-0.024905365,
-0.026999237,
0.017895447,
-0.0069643985,
0.038287934,
0.0003123331,
0.0046364297,
0.017336216,
0.0124396775,
-0.009786573,
-0.01845468,
-0.031421077,
-0.015268355,
0.038860172,
0.0047014565,
0.036285102,
-0.004568151,
0.014813165,
0.007523631,
0.03818389,
0.02049653,
-0.011145638,
0.035374723,
-0.0016646928,
0.033267844,
0.027701529,
-0.013902786,
0.0076276744,
0.0028205488,
-0.012771315,
0.0010217377,
0.011431757,
0.021901116,
0.00037736018,
-0.009721546,
0.0029375977,
-0.0034561884,
-0.017947469,
0.0057386383,
0.012075526,
-0.02069161,
-0.019169979,
-0.005829676,
0.010748974,
-0.002267819,
0.0065189633,
0.029600319,
-0.005283449,
-0.029964471,
0.009910124,
-0.0113797365,
0.0060735275,
0.007413085,
0.01967719,
-0.03053671,
0.0353227,
0.027545463,
-0.013772732,
0.021732045,
-0.009877611,
-0.015476441,
-0.007419588,
0.01040433,
-0.030354634,
-0.025152469,
-0.008264939,
-0.034308277,
-0.015502452,
0.055871252,
-0.00016724148,
0.016711956,
0.007777237,
-0.016711956,
0.031577144,
-0.014865187,
0.0020142132,
0.0005702061,
-0.025308533,
0.0056183385,
0.0242681,
0.013278526,
-0.01213405,
0.0033293855,
0.004490119,
0.0044218404,
-0.002111754,
-0.011691866,
-0.017778398,
-0.015853599,
-0.02407302,
-0.0038951212,
-0.03441232,
0.0059272167,
-0.033762053,
0.022668434,
0.015073273,
0.017128129,
0.0019394321,
-0.024658263,
-0.017154139,
-0.024229083,
0.014852181,
0.005992244,
-0.011750391,
-0.027519453,
-0.04981073,
-0.011483779,
-0.018480692,
0.017258182,
0.013408581,
-0.023799906,
0.014488029,
0.0055370545,
-0.03282566,
-0.022473354,
-0.007946307,
-0.010358811,
-0.021888109,
0.021888109,
-0.018077524,
-0.008687615,
0.042969882,
-0.038886186,
0.02633596,
-0.0060800305,
0.001322488,
-0.021536963,
0.01905293,
0.009624005,
-0.015918626,
-0.026036836,
0.0030952883,
0.028976059,
0.013525629,
0.0012143804,
0.024281105,
-0.031343043,
0.014084862,
-0.006717296,
0.021992153,
0.0039276346,
0.009845098,
0.0025506865,
-0.016698949,
-0.042397644,
-0.015710538,
-0.0106189195,
-0.0017849929,
0.04640331,
-0.014370981,
0.004438097,
-0.013525629,
0.019664183,
0.0074781124,
0.020184401,
-0.009604497,
0.011672358,
-0.004649435,
0.00027108158,
0.012907872,
-0.017752388,
-0.007491118,
-0.002970111,
0.011139136,
-0.009045265,
0.0009339512,
-0.011171649,
0.015359392,
0.011470774,
-0.0331638,
0.040186726,
-0.0028075434,
-0.0150212515,
0.02469728,
-0.0063141277,
0.008694119,
-0.0008412876,
-0.03365801,
-0.0014305954,
0.0040576886,
-0.0034139208,
-0.008811167,
0.014683111,
-0.015567479,
0.005543557,
-0.044660587,
0.020600574,
0.015255349,
0.015580485,
0.0034724453,
0.037013404,
-0.0024645256,
0.0054330113,
-0.025048425,
0.008466524,
0.026036836,
-0.008401496,
-0.013616667,
-0.0017671104,
0.011646347,
-0.032877684,
-0.0047729863,
0.0021475188,
0.0014110872,
-0.007133469,
-0.015697533,
0.0228245,
0.025789734,
0.010547389,
0.02840382,
-0.0098516,
0.0141759,
0.0050656083,
-0.0047079595,
-0.005475279,
0.005348476,
0.00020696895,
-0.018506702,
-0.027883604,
-0.015892614,
0.019495113,
-0.008440513,
0.010892034,
0.016178733,
0.01686802,
0.021588985,
0.021875104,
0.008577069,
-0.01933905,
0.006041014,
0.025698695,
0.029080102,
-0.0012598993,
0.010690449,
-0.0110806115,
-0.0020954972,
0.0023491026,
-0.003291995,
0.030978894,
0.0035049587,
0.0119909905,
-0.016907036,
-0.017297199,
-0.005312711,
0.012225088,
-0.032331455,
0.020795655,
-0.021810077,
0.011691866,
-0.013122462,
-0.013967813,
-0.008342972,
0.034230247,
0.002916464,
0.009955644,
-0.018935882,
0.011574817,
-0.011789407,
0.0126022445,
-0.013434592,
0.004464108,
0.008531551,
-0.0021897864,
0.0050688596,
0.0015565853,
-0.00083478494,
0.017674357,
-0.0038626075,
-0.018753804,
-0.026453009,
-0.013629672,
0.00809587,
0.04689752,
0.019742217,
0.0048542703,
0.023136629,
0.026192902,
0.004464108,
-0.006213336,
-0.0047892435,
-0.0018565226,
0.008401496,
-0.0018061267,
-0.0016029171,
0.0044998727,
-0.0020532296,
0.00057548954,
0.002950603,
0.02265543,
-0.031655174,
-0.014357976,
0.0041552293,
0.010683946,
0.01292738,
0.046247248,
0.018636756,
0.0153203765,
-0.009597994,
0.027597485,
0.03784575,
-0.0073025394,
-0.0027652758,
-0.01275831,
0.019859266,
-0.0034269262,
0.038652085,
-0.0038268426,
0.0005263128,
0.016881026,
-0.0302766,
0.026895193,
0.00014194188,
0.024619246,
0.00788128,
-0.006528717,
0.01400683,
0.019274022,
-0.0053517274,
0.0020028336,
0.052125692,
-0.0059239655,
-0.027051259,
0.014305954,
0.016178733,
0.012062521,
-0.03558281,
0.015372397,
-0.009376902,
-0.00579066,
-0.0019670688,
-0.0018971646,
-0.028924039,
0.002025593,
-0.011548807,
0.0074065826,
-0.012940385,
-0.011288698,
-0.015879609,
-0.029886438,
-0.0012737176,
-0.025555637,
0.019039923,
-0.00732855,
-0.01227711,
-0.005442765,
0.029236168,
-0.0034399317,
0.009233843,
0.023422748,
-0.015112289,
0.013980819,
0.035842918,
-0.027649507,
0.0017687362,
-0.003462691,
-0.026205907,
-0.0074976203,
-0.0052964543,
-0.012894867,
-0.029106114,
-0.024788316,
0.0028937042,
-0.019287027,
0.0011940595,
0.0025962056,
-0.0011347223,
-0.0077382205,
-0.0007400893,
-0.0134996185,
-0.003664275,
0.006873361,
-0.02194013,
0.008486032,
-0.010449849,
0.00031050423,
-0.009025756,
-0.012953391,
-0.014735132,
-0.013473608,
-0.01316798,
-0.0035374723,
0.004594162,
0.034204237,
-0.01064493,
-0.0028481854,
0.013434592,
0.00968253,
0.04944658,
-0.001703709,
0.035036582,
0.029886438,
-0.018753804,
-0.002217423,
-0.0064766956,
0.012868856,
0.013824753,
-0.02633596,
0.0020824918,
-0.009324881,
-0.01612671,
-0.042319614,
0.0011363479,
0.027649507,
0.026023831,
-0.01237465,
-0.026400987,
-0.015814582,
0.00732855,
-0.020184401,
0.011561812,
-0.03311178,
-0.017193155,
-0.0020743634,
-0.0140978675,
-0.0070359283,
-0.037611652,
0.04505075,
-0.035478767,
0.005322465,
-0.0006258855,
-0.020444509,
0.04471261,
0.014123878,
-0.0045063756,
-0.016087696,
-0.005836179,
-0.00802434,
-0.029236168,
-0.0050656083,
-0.0022873268,
0.04882232,
0.004486867,
0.017336216,
-0.0010030424,
0.029262178,
0.004356813,
-0.0012143804,
-0.013577651,
0.0018971646,
0.007387074,
-0.010677444,
0.017427253,
0.0077122096,
-0.012283612,
-0.0011574817,
0.008980238,
0.003976405,
0.013850764,
-0.037325535,
-0.036649253,
-0.015047262,
0.0018337632,
0.002232054,
0.002472654,
-0.0012021879,
0.02392996,
-0.03118698,
-0.0046006646,
-0.0016468103,
0.023214662,
0.014240927,
0.007107458,
0.012966396,
-0.02993846,
0.024866348,
-0.020054346,
-0.008440513,
-0.010540887,
-0.014449013,
-0.0046819486,
-0.013941802,
-0.005845933,
-0.0038040832,
0.036805317,
-0.0002672206,
-0.011431757,
-0.02035347,
0.01023526,
-0.013024921,
0.0008599829,
-0.00036882536,
-0.019222,
-0.0141759,
0.0019882026,
-0.02049653,
-0.01604868,
-0.011139136,
0.022070186,
-0.017362226,
0.027597485,
-0.01037832,
-0.01434497,
-0.02458023,
-0.023058597,
0.027051259,
-0.01797348,
0.02316264,
0.018311622,
-0.0070294254,
-0.03053671,
0.0058199223,
-0.021341883,
0.0034009153,
0.028065681,
0.007335053,
0.004041432,
-0.02191412,
-0.010950558,
0.012673775,
-0.025672685,
-0.033579975,
0.010059686,
0.019300032,
0.0027571474,
-0.003236722,
0.012121045,
-0.017362226,
0.034308277,
-0.020535547,
0.0041844915,
0.009624005,
-0.013629672,
0.020730628,
0.043750208,
-0.015658516,
0.019378064,
-0.0077577285,
-0.0033846586,
0.022239255,
-0.041435245,
-0.027363388,
0.01254372,
-0.0031993315,
0.022109201,
0.015229338,
-0.0003818308,
0.01746627,
-0.00829095,
0.009597994,
-0.016477859,
-0.013395575,
0.03188927,
0.014982236,
-0.01234864,
0.0110806115,
0.0025555636,
0.016373815,
-0.015918626,
-0.011093617,
-0.018870853,
-0.0069058742,
-0.007868275,
0.015996657,
-0.0012086906,
-0.01684201,
0.004272278,
-0.022876522,
-0.0062003303,
-0.0058491845,
-0.021797072,
0.01871479,
-0.018636756,
-0.0141759,
0.0060897847,
-0.021380898,
-0.0007770734,
0.008850183,
-0.02069161,
0.00015108632,
-0.0056963707,
-0.027025247,
0.027649507,
0.0025701947,
0.0030920368,
-0.015840592,
0.015437425,
-0.047443744,
-0.023097614,
0.0060605225,
0.008811167,
-0.039198313,
-0.016894031,
0.020184401,
0.0012493324,
-0.007575653,
-0.0151383,
0.02554263,
0.015554474,
0.00829095,
-0.003137556,
-0.0125892395,
0.0063011223,
-0.013057434,
0.0032806154,
0.033527955,
-0.008525048,
0.01590562,
-0.012478693,
-0.0009063147,
0.009266357,
-0.027961638,
0.013915791,
-0.024983399,
0.04354212,
-0.009454935,
0.019195989,
-0.00025340234,
-0.0031554382,
-0.017518291,
0.012257601,
-0.0017150888,
-0.021732045,
0.021003742,
-0.0036675264,
0.020145385,
0.0004913607,
-0.018818833,
-0.015775565,
-0.015632506,
-0.000530377,
-0.024359139,
-0.0024970393,
-0.007100955,
0.026257928,
0.028507864,
-0.024307117,
0.003947143,
0.012719294,
-0.03186326,
-0.020418499,
0.004363316,
-0.0035699857,
-0.0060052495,
-0.005644349,
0.027961638,
0.009480946,
-0.004945308,
-0.0011656102,
-0.030354634,
-0.010287281,
-0.0036350128,
-0.02775355,
0.03246151,
-0.014462019,
-0.023006575,
-0.005289952,
0.014383987,
-0.01783042,
0.00677582,
-0.0023799904,
0.013590656,
0.01859774,
-0.023149634,
0.010527882,
-0.004509627,
-0.0106189195,
0.027233334,
-0.007022923,
0.007100955,
0.0030237585,
0.0036740291,
-0.0017427253,
-0.02614088,
-0.004951811,
-0.0040999562,
0.014865187,
-0.034204237,
-0.00037227993,
0.0046331785,
-0.01842867,
-0.008518545,
-0.00019904377,
0.007491118,
-0.011373233,
0.0060897847,
-0.008830675,
0.0007368379,
0.010176735,
-0.018532714,
0.0012330757,
0.015827587,
0.008824172,
-0.029470265,
0.008414502,
0.016894031,
-0.004899789,
0.025802739,
0.008934719,
-0.016542885,
-0.0033716531,
0.022889527,
-0.008590075,
0.008583573,
-0.019378064,
-0.013447597,
-0.00715948,
0.012660769,
-0.009149307,
-0.0029684855,
-0.022772478,
-0.0153333815,
0.014253932,
-0.020535547,
0.03742958,
-0.0041194647,
-0.019013913,
-0.017310204,
0.024255095,
0.19195989,
0.0011517919,
-0.011087114,
0.028559886,
0.002297081,
0.014266938,
0.04390627,
0.016907036,
-0.026322955,
-0.002498665,
0.008947724,
0.01355164,
-0.006970901,
0.0074000796,
0.026413994,
0.0020174647,
-0.024320122,
-0.00398941,
0.014566062,
0.0015720293,
0.008167399,
-0.0065157115,
0.008596578,
-0.010970065,
0.028299779,
0.0021198823,
-0.02381291,
0.020925708,
0.020145385,
-0.004217005,
-0.005163149,
-0.012043012,
0.0030091275,
0.018545719,
0.02965234,
0.0057744035,
0.005732136,
-0.0060540196,
-0.0020776147,
-0.028273767,
0.0038886184,
-0.0000040864174,
-0.0018630254,
-0.017024085,
-0.016855014,
0.008570567,
-0.0053257165,
-0.006483198,
0.0033456425,
-0.0036967886,
-0.018168561,
0.012023504,
0.024957387,
0.0030286354,
-0.024476187,
0.017245177,
0.03498456,
-0.0081999125,
0.0047307187,
0.008238929,
-0.012322629,
-0.004590911,
-0.0010940804,
0.016165728,
-0.011022087,
-0.000013488036,
-0.00732855,
-0.0081999125,
-0.032305446,
-0.0027278853,
0.00028083564,
-0.0197032,
-0.019039923,
0.013076942,
-0.017583318,
-0.021549968,
0.026218912,
0.00567036,
0.012953391,
0.020340465,
-0.0130509315,
-0.04263174,
-0.003947143,
-0.0036902858,
-0.0041324697,
-0.014058851,
0.01141225,
0.021224834,
0.0033050005,
0.00014692052,
-0.0058979546,
0.00057589595,
-0.0059142113,
-0.0041032075,
0.021328878,
-0.029808406,
-0.021250844,
-0.0049290513,
-0.011847931,
-0.022720456,
-0.018818833,
0.08510742,
-0.0061353035,
-0.00487703,
0.004145475,
-0.00027006553,
-0.0025474352,
0.025893776,
0.009324881,
0.0077382205,
0.0028985813,
-0.014683111,
0.0013298035,
-0.011308206,
-0.0035829912,
0.009071276,
0.03056272,
-0.040134702,
0.013642678,
-0.01953413,
-0.005348476,
0.003901624,
0.017310204,
0.020457514,
-0.011132633,
-0.007309042,
-0.00040824804,
0.011184655,
-0.023968976,
0.0023393487,
-0.006951393,
-0.01718015,
-0.017154139,
0.004363316,
-0.011522796,
-0.011665856,
0.014188905,
0.0053094598,
0.008635594,
0.01619174,
-0.015801577,
0.0022222998,
-0.014331965,
0.0004328364,
0.0022694445,
-0.02265543,
0.0029424746,
0.0037780723,
-0.017544301,
0.0045779054,
0.0054915356,
0.005208668,
0.0047859917,
-0.0034204235,
0.03649319,
-0.004750227,
-0.010898536,
-0.03727351,
0.00715948,
0.0023994986,
-0.0119779855,
-0.0026303448,
0.015463436,
-0.025607657,
0.0025360554,
0.0022661933,
-0.16293181,
0.034256257,
0.02568569,
-0.020379482,
0.030718785,
0.00019884057,
0.033788063,
0.01664693,
-0.026023831,
-0.011659352,
0.015151306,
0.014878192,
-0.037689686,
-0.017115124,
0.0048120026,
0.003137556,
-0.015619501,
0.021979148,
0.01672496,
0.021732045,
0.006951393,
0.0034952047,
-0.012725797,
0.0050428486,
0.016347803,
0.04346409,
-0.012888364,
0.008355978,
-0.007354561,
-0.0023799904,
-0.012335634,
0.014071857,
0.021810077,
0.01590562,
-0.0072115012,
0.0015175691,
0.009006248,
-0.0017719875,
-0.00066368247,
0.020535547,
0.0077577285,
0.027441422,
-0.0019443092,
0.010254768,
-0.0021605243,
0.02392996,
-0.01593163,
-0.021719038,
0.014045846,
-0.024827333,
0.00487703,
-0.02993846,
0.009311875,
-0.017284194,
0.00030400153,
0.005423257,
0.00036374514,
0.00027717787,
-0.005446017,
-0.01763534,
-0.001994705,
-0.030328622,
0.015970647,
0.0074260905,
0.021732045,
-0.010274276,
-0.010657935,
0.0037227995,
-0.015203328,
-0.020912703,
-0.0302766,
0.0018483943,
-0.010508373,
0.016959058,
0.019326042,
0.013525629,
-0.024216078,
0.01420191,
0.021198822,
-0.017076107,
-0.013642678,
-0.012218585,
-0.035426743,
0.0041682348,
-0.0049680676,
0.01213405,
0.03683133,
0.022499364,
-0.0080503505,
0.0017573563,
0.040810984,
-0.03342391,
0.01842867,
-0.038235914,
0.0005925591,
0.0035764885,
-0.0025555636,
0.023344716,
0.009214335,
-0.020028336,
0.018129546,
-0.024489192,
-0.03719548,
0.019195989,
0.009123297,
-0.022083191,
-0.010456352,
0.012569731,
0.042007484,
-0.01701108,
-0.0077642314,
-0.0025263014,
-0.0197032,
0.02991245,
0.0007852018,
0.03204534,
0.006041014,
-0.017323209,
0.0068603554,
-0.011451266,
0.04257972,
-0.012400661,
0.0103328,
0.020925708,
0.0035764885,
-0.01890987,
-0.11361528,
-0.030666763,
-0.008843681,
0.00006660194,
0.00598249,
0.038079847,
-0.023032585,
-0.013668689,
-0.008167399,
0.019404076,
-0.019235006,
-0.01268678,
-0.022434337,
-0.015944635,
0.031239001,
-0.00043405566,
0.0046624406,
-0.027857594,
-0.009819087,
0.044998728,
0.02222625,
-0.013330548,
0.0049030404,
-0.010911541,
-0.00040276136,
-0.004916046,
-0.0054850327,
-0.004558397,
-0.006691285,
-0.0069578956,
0.008947724,
0.009467941,
0.005442765,
-0.018805826,
-0.021667017,
-0.010605914,
-0.0005706125,
-0.01811654,
0.018129546,
-0.018766811,
0.0112171685,
0.013395575,
0.011321212,
-0.003914629,
0.0025913285,
-0.014084862,
-0.017427253,
0.001281846,
0.014357976,
-0.022876522,
-0.028715951,
-0.02285051,
-0.00499733,
0.007621172,
0.01619174,
-0.009890616,
0.0061580627,
0.0026254677,
0.018103534,
0.00634339,
-0.002724634,
0.027961638,
-0.03469844,
0.012972899,
0.01638682,
-0.02554263,
-0.02676514,
-0.026661096,
-0.008739637,
-0.0242681,
-0.023682857,
-0.0019589402,
-0.0012322628,
0.019039923,
-0.004922549,
0.009591492,
-0.035374723,
-0.02863792,
0.016347803,
-0.03597297,
-0.0008278758,
-0.027155302,
0.01528136,
-0.003986159,
0.015671521,
0.0075886585,
-0.010774984,
-0.011171649,
-0.016035674,
-0.0069188797,
-0.018181566,
0.0353227,
0.043282013,
-0.037091438,
-0.0002635628,
0.010189741,
0.0023458514,
-0.012296618,
0.030042503,
-0.013115958,
-0.02772754,
-0.000040387902,
-0.051137283,
0.016347803,
0.0024791567,
-0.014279943,
-0.01664693,
0.01684201,
0.014449013,
0.008128383,
0.016100701,
0.00850554,
-0.035166636,
0.024840338,
-0.027077269,
0.0018061267,
-0.023591818,
-0.040784974,
0.015307371,
0.020574562,
0.02239532,
0.032981727,
0.0044250917,
-0.008004831,
0.02032746,
0.0187408,
-0.0013940177,
0.018766811,
-0.013655683,
-0.009077778,
-0.011347222,
-0.00449337,
-0.005348476,
-0.010735968,
-0.01451404,
0.009780071,
-0.0153333815,
-0.024762306,
-0.00559883,
0.010352309,
0.03152512,
0.025802739,
0.014605079,
0.010267774,
0.001608607,
-0.020223416,
0.009773567,
0.022044174,
-0.01355164,
-0.004844516,
0.008921714,
-0.0039731534,
0.022291277,
0.020821666,
0.018350637,
-0.016959058,
0.0067628147,
0.012075526,
0.01621775,
0.028143713,
-0.036623243,
-0.006268609,
0.008427507,
-0.028741961,
-0.008512042,
0.010859519,
0.01323951,
-0.03155113,
0.0038170887,
0.0004074352,
0.0033212572,
-0.029990481,
0.0026466015,
-0.006401914,
-0.0056638573,
-0.0040056673,
-0.0044250917,
0.01234864,
-0.0062653576,
0.020015331,
0.011425255,
0.025581647,
-0.0076341773,
0.01746627,
-0.029730374,
0.017856432,
0.02424209,
0.0065417225,
-0.024216078,
0.0017199658,
-0.00684735,
0.009279362,
0.0032237167,
0.0026612326,
0.0002887608,
-0.004408835,
-0.00002165452,
0.00091119175,
0.007575653,
-0.009702038,
0.004204,
0.012881861,
0.009838595,
0.009318378,
-0.008115377,
-0.022278272,
-0.025100447,
-0.021042759,
0.0040544374,
-0.047339704,
-0.013187489,
0.0077902423,
0.002734388,
0.028585898,
-0.010755477,
-0.0044218404,
0.005218422,
0.02157598,
-0.008381989,
-0.00023165891,
-0.024112035,
0.0063856575,
-0.0014232799,
0.011568314,
0.005673611,
-0.010612417,
0.020678606,
0.017258182,
0.036363132,
-0.014605079,
0.045232825,
0.0069904095,
0.020704618,
0.005091619,
-0.010495368,
-0.0021150052,
0.020860681,
-0.022616412,
0.017765393,
0.0014671731,
0.007289534,
0.065079086,
-0.012186072,
-0.0076341773,
-0.0017557307,
0.012394158,
0.03657122,
0.024710285,
0.014501035,
-0.0054915356,
0.0110676065,
-0.0013753223,
-0.007796745,
-0.0004966442,
-0.023877937,
-0.010833508,
0.007367566,
0.00095589785,
0.0060052495,
-0.007614669,
-0.0040544374,
0.013642678,
-0.0014631089,
0.0018191321,
0.022733461,
-0.018935882,
-0.014579068,
0.007126966,
0.0017817415,
-0.0125892395,
-0.02650503,
-0.02112079,
0.025399571,
-0.022148218,
-0.009728049,
0.040576886,
-0.02900207,
-0.017414248,
-0.0024092528,
0.018363643,
-0.011054601,
0.018272605,
-0.019742217,
-0.017024085,
-0.009415919,
-0.02327969,
-0.031993315,
-0.007959313,
-0.016542885,
-0.03602499
] |
Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the RNA binding protein Musashi 2, which plays a key role in AML. We generated Tspan3 knockout mice that were born without overt defects. However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly improved survival in mouse models of AML. Additionally, T | [
-0.020092862,
0.0014321903,
-0.004732895,
-0.02970719,
-0.0110254185,
0.01959324,
-0.026344875,
0.0053574215,
-0.027708706,
-0.0054451926,
0.011545294,
0.0048240423,
0.0042872876,
0.003963209,
-0.016744051,
0.0019343431,
0.027951764,
-0.012362242,
-0.012922627,
0.001271839,
-0.04777456,
0.009756111,
0.007298516,
-0.01574481,
0.002565621,
0.0075010653,
0.008284255,
-0.040806875,
-0.009688594,
-0.012801098,
0.026695961,
-0.010431275,
-0.00892566,
-0.012146189,
-0.018296927,
0.0039328267,
0.03086847,
-0.014853595,
0.022604471,
-0.006842781,
0.013253457,
0.023765752,
-0.0046012383,
-0.008608333,
-0.017945843,
-0.015069647,
-0.008236993,
-0.004071235,
-0.02607481,
0.008527313,
0.023212118,
0.0051008593,
-0.01781081,
0.0072174966,
-0.012888869,
-0.014651045,
0.010431275,
0.020322418,
-0.001197571,
-0.0005844383,
0.022698993,
0.008318013,
-0.020781528,
0.0001861974,
-0.000021006548,
0.015137163,
-0.009654837,
0.012382496,
0.01987681,
0.0025217352,
0.032002743,
0.021996824,
0.0020980702,
-0.012801098,
-0.0015208055,
-0.015758313,
-0.019863307,
-0.000057863614,
-0.025629202,
-0.00077010825,
0.02814081,
-0.012105679,
-0.016055385,
0.00048738357,
0.009141712,
-0.0006321217,
0.007912915,
0.007453804,
0.014880601,
0.013280463,
0.0070284507,
0.006559212,
0.014272954,
0.017176157,
-0.033974223,
-0.0069946926,
0.0021436438,
0.008729863,
-0.010485288,
-0.038619347,
-0.010174712,
0.0048611765,
-0.0030838088,
-0.008264,
-0.03653984,
0.0021993448,
-0.001936031,
0.016122902,
0.022631478,
0.00004203947,
-0.0151101565,
0.028302848,
0.016068889,
-0.048422717,
0.00925649,
-0.018418457,
0.012078673,
0.0012583358,
-0.010167961,
0.0053776763,
0.029194064,
0.043858614,
-0.009283497,
-0.011828862,
0.017648771,
0.02124064,
-0.016338954,
-0.014326967,
-0.035027478,
0.00066883373,
0.015204679,
0.020889556,
0.009276745,
0.018702026,
-0.021645738,
0.01251753,
-0.00921598,
-0.03165166,
-0.027344117,
-0.041806117,
-0.017257176,
0.022158863,
-0.0018904575,
-0.010053183,
0.0121259345,
-0.008189732,
0.018891072,
-0.014029895,
0.0052899052,
0.0037133987,
0.008574575,
-0.014259451,
0.022698993,
-0.0036357548,
-0.010681084,
0.014434993,
-0.019890314,
0.022010326,
-0.008689353,
-0.035891686,
0.007541575,
0.000978987,
0.028005777,
0.021348666,
0.016068889,
0.036647867,
-0.013077915,
0.0073255226,
-0.02045745,
-0.012497274,
-0.0032137777,
0.014651045,
-0.009654837,
0.013199444,
-0.021051595,
-0.0012321732,
-0.009087699,
0.027573673,
-0.026601437,
-0.013165686,
-0.0060629672,
0.010586562,
0.008912156,
0.004294039,
-0.021078601,
-0.0004996209,
0.026885007,
-0.015231686,
0.0014634166,
-0.013327725,
0.012416255,
0.019147635,
0.0043818103,
-0.007399791,
-0.62741584,
-0.023954798,
0.009344261,
0.012861863,
0.02962617,
0.008432791,
0.012720078,
-0.014583529,
-0.02529162,
0.014016392,
-0.012362242,
0.01247702,
0.0036290032,
-0.017000614,
-0.006123732,
-0.021659242,
-0.015339713,
-0.031300575,
0.02368473,
-0.002786737,
-0.02186179,
-0.0013688938,
-0.00081357185,
0.01132249,
-0.001714071,
0.006653735,
0.009128209,
-0.02417085,
0.0010574746,
0.035054483,
-0.02627736,
0.04015872,
0.0030686175,
0.007507817,
0.040644836,
-0.010728346,
-0.0035446077,
0.02970719,
0.011727588,
0.020835541,
0.004169134,
0.021605229,
0.008068202,
0.0014558211,
-0.00818298,
0.008054699,
0.008405784,
0.0066638626,
-0.0040104706,
-0.015542261,
0.004388562,
-0.0007912071,
-0.023779254,
-0.01037051,
0.0056578694,
0.013921869,
0.034514353,
-0.020227894,
0.014907608,
-0.007912915,
-0.01875604,
0.0014642606,
-0.02061949,
-0.019188143,
-0.008297758,
-0.009411777,
-0.016325451,
0.019687764,
0.014205438,
-0.0069946926,
0.019687764,
0.0055802255,
-0.01644698,
0.009769614,
0.0029842223,
0.03810622,
-0.01508315,
0.012504026,
-0.0006747414,
-0.011538542,
0.0039362027,
-0.009060693,
-0.01590685,
-0.010728346,
0.05860418,
0.0018516356,
-0.027141567,
0.015974365,
0.015731307,
0.0046620034,
0.0037235261,
0.0010372198,
-0.0032897335,
-0.038727373,
-0.016109398,
0.008743366,
-0.0022617974,
0.005198758,
0.016109398,
-0.021078601,
-0.022753006,
-0.0039767125,
0.015407229,
-0.009769614,
-0.0013967443,
0.0056578694,
-0.030922484,
0.0052595227,
0.025548182,
-0.01586634,
0.004631621,
0.004965827,
0.0032610393,
-0.028734954,
0.020687006,
-0.009351013,
0.0042872876,
0.022780012,
0.0023731992,
-0.030436365,
0.006211503,
0.014583529,
0.021551216,
0.00080302247,
0.009513052,
0.0095873205,
0.032218795,
-0.0073255226,
-0.0018499477,
-0.022131857,
0.00342983,
-0.009978915,
0.023468679,
-0.035837673,
0.051717516,
-0.016757555,
0.014434993,
0.009681843,
0.02462996,
-0.020957071,
-0.029842222,
-0.019066613,
-0.0010583187,
-0.006015706,
-0.00937802,
-0.0073862877,
-0.009783117,
-0.013158934,
0.015366719,
-0.017162653,
-0.0019444706,
0.008743366,
-0.014097411,
0.01504264,
0.015596274,
-0.022131857,
-0.0033589378,
-0.023455177,
-0.0020558725,
-0.037944183,
-0.022658484,
-0.0013722696,
0.009803372,
0.017959347,
0.009060693,
-0.018999098,
-0.013003646,
0.003929451,
-0.015137163,
-0.019026104,
-0.0035311044,
-0.006214879,
-0.028329855,
-0.004520219,
-0.018783046,
0.028356861,
-0.0033032368,
0.0012313293,
-0.0049151895,
-0.0004371683,
0.0011832238,
-0.005087356,
0.010971405,
-0.0021892174,
0.02661494,
0.029977255,
0.033218037,
0.013327725,
0.01929617,
0.015447739,
-0.031084523,
0.01371932,
-0.03913247,
0.025089072,
0.008331516,
-0.016379464,
0.005067101,
0.017783804,
-0.004186013,
0.032380834,
-0.004628245,
-0.012375745,
0.0033791927,
-0.003002789,
0.015474745,
-0.029815216,
-0.009816876,
-0.020349424,
0.009209229,
0.017918836,
-0.011153699,
-0.004189389,
-0.018566994,
-0.0031260066,
0.012544536,
0.0059245587,
0.009357764,
-0.008324765,
0.011579053,
-0.018229412,
-0.012193451,
0.010093693,
0.00063380966,
-0.021618731,
0.00078276754,
0.017446222,
0.028437883,
0.022266889,
-0.0026111945,
-0.009344261,
-0.010694588,
0.008014189,
0.020146875,
0.018526483,
0.018445464,
0.002066,
0.031624652,
-0.001364674,
0.033731163,
-0.013989385,
-0.007595588,
-0.0003852651,
0.005620735,
0.0010262483,
0.018256418,
-0.012801098,
0.031840704,
0.021969816,
0.009769614,
0.03686392,
-0.027465647,
0.020470954,
-0.026398888,
0.0055599706,
-0.0025740603,
-0.017257176,
-0.0067077484,
0.026493412,
0.015798824,
0.020308916,
0.040833883,
0.015285699,
-0.0010667582,
-0.006471441,
0.011815359,
-0.0071634836,
0.014840092,
-0.010228725,
0.010971405,
0.010181464,
-0.0355406,
-0.0016094208,
0.009121457,
-0.04831469,
-0.007629346,
0.01346951,
0.0056544933,
0.009870889,
0.018823555,
0.0027512908,
-0.0058705457,
-0.058334116,
0.04302141,
0.024346393,
-0.030922484,
-0.024886522,
-0.006690869,
-0.00051903183,
-0.017513739,
0.014637542,
0.011254974,
0.01293613,
-0.008628588,
0.005067101,
-0.02954515,
0.0004295727,
0.03103051,
-0.007041954,
0.010235477,
-0.004901686,
0.010498791,
-0.011403509,
-0.006127108,
-0.005016464,
0.020308916,
-0.0053810524,
-0.001143558,
-0.013523523,
-0.022293895,
-0.020754522,
-0.004719392,
-0.023563202,
-0.005063725,
-0.023414666,
0.008662346,
-0.008372026,
0.01839145,
0.0077373725,
0.010059934,
-0.025170092,
-0.019309673,
-0.032488864,
0.01644698,
0.017824313,
0.036377802,
0.029086038,
-0.007939922,
-0.00021710723,
0.004719392,
-0.0037910424,
0.008824386,
-0.0057760226,
0.022496443,
-0.008817634,
-0.02681749,
0.028680941,
0.006987941,
0.0052662743,
-0.0004293617,
0.042292234,
-0.008972921,
-0.024643464,
-0.0101409545,
-0.0050941077,
0.026128823,
-0.0026517042,
0.03111153,
0.027222589,
0.015177673,
-0.0036290032,
-0.027924757,
-0.0023208742,
0.0077913855,
-0.01003968,
-0.005792902,
-0.004256905,
-0.011444019,
0.020957071,
-0.013935372,
-0.026425894,
0.014799582,
0.023644222,
0.006059591,
-0.007744124,
0.019768784,
0.020389935,
-0.0020862548,
0.01375983,
-0.021605229,
-0.0108026145,
-0.006211503,
0.00008977563,
0.00049329124,
-0.02711456,
0.023077084,
-0.013152183,
-0.03618876,
-0.0099721635,
0.025588693,
0.015339713,
-0.012747085,
-0.016865581,
0.0052493955,
-0.009533307,
0.008500307,
-0.02838387,
0.0032255931,
0.006258765,
0.0063296566,
-0.03251587,
0.004945572,
0.018053869,
-0.02938311,
-0.0032407842,
0.01731119,
-0.010944398,
-0.03545958,
0.0040273494,
0.018323934,
0.030787451,
0.021011084,
-0.023873778,
-0.0145565225,
0.042589307,
-0.0062418855,
-0.009344261,
-0.0019039607,
-0.035054483,
0.016838575,
-0.007980431,
0.02248294,
-0.024846012,
-0.020389935,
0.012395999,
0.00265508,
-0.014597032,
0.018999098,
0.004499964,
-0.0046822582,
0.010492039,
0.024116836,
0.026371881,
-0.0120179085,
0.00793317,
-0.015366719,
-0.04053681,
-0.037404053,
-0.014705058,
-0.028518902,
-0.008257248,
0.007960176,
0.0009680155,
-0.02350919,
-0.017797306,
-0.00460799,
0.008547569,
0.0031428856,
0.005063725,
0.013665307,
-0.00063338765,
-0.002450843,
0.018364444,
0.01768928,
0.0034770914,
-0.017459726,
-0.018742535,
0.015569268,
0.01512366,
-0.010924144,
0.01628494,
0.017297685,
-0.004732895,
0.00035910253,
-0.025818247,
0.016460484,
0.0355406,
-0.011916634,
-0.024305882,
-0.016082391,
-0.0014245948,
0.0012127622,
0.002764794,
0.012942882,
-0.014597032,
-0.01789183,
0.009060693,
-0.0037944182,
-0.015380222,
0.020241398,
-0.029032025,
-0.020497961,
0.01313868,
0.0006131327,
0.0035479837,
-0.022280391,
0.011092935,
-0.020497961,
-0.016582012,
-0.024400406,
-0.015677294,
0.008412536,
-0.019390693,
0.043696575,
0.029761203,
0.04747749,
0.0016828447,
0.010492039,
-0.0027344117,
-0.006292523,
0.008088457,
-0.022145359,
0.023725241,
0.0058772974,
0.020052353,
0.010674333,
-0.005583601,
0.017999856,
-0.01835094,
0.02711456,
0.038484313,
-0.017540745,
-0.013158934,
0.018823555,
-0.04661328,
-0.029329097,
0.03351511,
-0.01578532,
0.00072115887,
-0.03726902,
-0.00043041667,
0.03459537,
0.008588078,
0.01380034,
0.01933668,
0.030409358,
-0.009222732,
0.013131928,
-0.010768856,
0.020065855,
-0.004412193,
-0.0035142254,
-0.0041421275,
-0.011680326,
0.017540745,
0.004412193,
0.0020778154,
0.02677698,
-0.015326208,
-0.0064444346,
0.0075010653,
-0.030976497,
-0.023333646,
-0.02103809,
-0.030382352,
-0.016352458,
-0.00789266,
-0.0077711307,
-0.03462238,
-0.00014600408,
-0.0049725785,
-0.008230242,
0.008419287,
-0.009553562,
0.0006941524,
0.044938873,
0.0012279534,
0.020308916,
-0.01913413,
0.0064815683,
0.015731307,
-0.005347294,
-0.019849803,
-0.029410116,
-0.0075685815,
0.007926418,
0.027209084,
0.033218037,
-0.045884103,
0.011086183,
0.0059549413,
0.013550529,
-0.014407987,
-0.035432573,
0.021213634,
-0.013172437,
0.0018904575,
-0.016555006,
-0.014637542,
-0.033947214,
0.019188143,
-0.004577608,
-0.0039226995,
0.019107124,
-0.014934614,
-0.010728346,
0.038322274,
0.013685562,
0.00892566,
-0.004736271,
-0.02978821,
0.012200203,
-0.01223396,
-0.020416941,
0.0046755066,
-0.0120719215,
0.04893584,
-0.002157147,
0.013827346,
0.019458208,
0.0065625883,
-0.0039767125,
0.0025470539,
-0.006802271,
0.040185723,
-0.00789266,
0.006825902,
0.028815974,
-0.0002804038,
0.0035243528,
-0.0021318283,
-0.0011452459,
0.007298516,
-0.050961334,
-0.0003669091,
0.037782144,
-0.004867928,
-0.010154458,
-0.0028103676,
-0.023077084,
-0.02322562,
-0.02252345,
-0.02805979,
-0.006967686,
-0.047261436,
-0.036836915,
0.007467307,
0.009729104,
0.0151641695,
-0.005195382,
-0.010336751,
-0.004476333,
0.029761203,
-0.010269235,
0.0043277973,
-0.00018894025,
-0.0005996295,
-0.020903058,
0.0034703398,
0.0003428564,
-0.028896993,
0.005347294,
-0.027074052,
-0.021794274,
-0.005296657,
0.008034444,
0.018323934,
0.00497933,
-0.022671986,
0.0042298986,
-0.019539228,
0.005131242,
0.010546052,
-0.0020153627,
0.02846489,
-0.032488864,
0.014110914,
-0.008898653,
0.0028947631,
-0.003355562,
0.0024052695,
-0.019404195,
-0.016028378,
0.0009004992,
-0.014610535,
0.00052282965,
-0.012423006,
-0.01789183,
-0.0032931094,
0.0012228896,
-0.004813915,
-0.01574481,
-0.0126053,
0.00979662,
0.0005198758,
0.009276745,
0.010255732,
0.009020183,
0.0016052009,
-0.037620105,
0.016555006,
0.0051008593,
-0.013611294,
-0.028545909,
-0.005735513,
-0.022145359,
0.016149908,
-0.000239472,
-0.00752132,
-0.008777124,
0.01582583,
-0.05665971,
-0.019660758,
0.015177673,
0.015623281,
0.015461242,
0.03367715,
-0.009209229,
0.010600065,
0.0010363758,
-0.009188973,
0.0075145685,
-0.0049151895,
0.009297,
-0.012213706,
0.003504098,
0.0029048906,
-0.036836915,
-0.009101203,
0.023617215,
-0.0110254185,
-0.027155071,
0.041374013,
-0.016555006,
0.0012127622,
-0.016541503,
0.004962451,
-0.012963137,
0.0077036144,
0.017756797,
-0.020241398,
0.0017351699,
0.008304509,
0.008655595,
-0.021713255,
0.009681843,
0.0055802255,
0.011808608,
-0.0023090588,
-0.012780843,
-0.021578223,
-0.002876196,
-0.009276745,
0.02846489,
0.018688522,
0.020592483,
0.022509947,
-0.005738889,
0.010107196,
0.0007612467,
-0.01095115,
-0.022293895,
-0.024575947,
0.01280785,
-0.0066841175,
-0.022671986,
0.0033656894,
-0.021227136,
0.0030196682,
-0.012139438,
0.013631549,
-0.03437932,
-0.031624652,
0.018648013,
-0.01062032,
-0.014137921,
-0.004186013,
0.0056882515,
-0.023860274,
-0.021605229,
0.0010254044,
0.018296927,
-0.008574575,
-0.00917547,
-0.004925317,
0.0008452202,
-0.004165758,
0.022861032,
-0.004179261,
-0.009195725,
0.013645052,
0.20924664,
-0.030436365,
0.0030162924,
-0.0070284507,
0.016514497,
-0.01987681,
0.03256988,
0.0038956928,
-0.01062032,
0.006322905,
0.020997582,
-0.010984908,
-0.0013942124,
0.0005418186,
0.003831552,
-0.00067094364,
-0.024562445,
0.0026230097,
-0.038160235,
-0.031705674,
-0.007372784,
0.0062553887,
0.027587175,
-0.0013663619,
0.005239268,
0.021159621,
-0.01893158,
0.0067617614,
0.0029234574,
-0.005009712,
-0.034487344,
0.0113562485,
-0.020511463,
-0.0016068888,
0.009634581,
-0.013867856,
-0.00069795013,
-0.0039024444,
0.001087013,
0.021254143,
-0.010735098,
0.0061473628,
0.0028660686,
0.006306026,
0.0056342385,
0.01636596,
-0.016055385,
0.0015579396,
-0.0001023822,
0.0065322057,
-0.038160235,
0.011639817,
0.021510705,
0.015393726,
0.0027749215,
0.019687764,
0.019282667,
0.014016392,
-0.005914431,
0.018972091,
-0.00049708906,
-0.012132686,
-0.017864823,
0.01664953,
0.00041438153,
0.037404053,
0.0002877884,
0.021105608,
0.027573673,
-0.013030654,
-0.0043379245,
-0.017905332,
0.0015056144,
0.001346107,
-0.015771817,
-0.018404953,
0.02276651,
0.001493799,
0.01839145,
-0.006967686,
0.00937802,
-0.0075348234,
-0.03143561,
0.018918078,
0.01276734,
-0.024454419,
0.010674333,
0.007156732,
0.0007080776,
-0.017324692,
0.017405713,
-0.025683215,
-0.0050434703,
0.014934614,
0.013206196,
0.009161967,
0.0006245261,
0.007285013,
-0.010167961,
-0.021470197,
-0.041563056,
0.059846483,
-0.0041387514,
0.025237607,
-0.0089796735,
0.0061203563,
-0.01251753,
0.00033652675,
-0.012450013,
-0.006025833,
-0.00031226306,
-0.018891072,
0.0053202873,
-0.0063532875,
-0.0064241798,
0.0037471568,
0.02338766,
-0.007433549,
0.045803085,
-0.0067516337,
-0.021848287,
-0.023009568,
0.008236993,
0.030571397,
-0.005016464,
-0.003578366,
-0.020349424,
-0.025170092,
-0.02446792,
-0.0002268127,
-0.0021081977,
0.025480667,
0.010654078,
-0.0008777124,
-0.017648771,
-0.020416941,
0.002194281,
0.006336408,
-0.020916563,
0.020416941,
-0.0030162924,
-0.0081492225,
0.008345019,
0.013658555,
-0.004975954,
-0.018621007,
0.012922627,
0.029086038,
-0.019741777,
-0.01781081,
-0.01991732,
0.0033454346,
-0.022698993,
-0.004402065,
0.020605987,
-0.012065169,
-0.009850634,
-0.027641188,
-0.000096896496,
0.01967426,
-0.025561687,
0.030031268,
0.0019512222,
-0.0010414395,
0.0007093435,
-0.0030888724,
-0.17132947,
0.00052620546,
0.006292523,
-0.016325451,
0.024819005,
0.0022398545,
0.011680326,
-0.026101816,
0.0010946087,
0.007467307,
0.043858614,
-0.007676608,
-0.039645594,
-0.038862403,
-0.0071702353,
-0.0044830847,
0.0037775391,
0.02946413,
0.043642562,
0.017905332,
0.0007038578,
-0.0070689605,
0.01714915,
-0.00019083916,
-0.01913413,
-0.0011081119,
0.008608333,
-0.02938311,
-0.018458966,
0.0048375456,
-0.018067373,
0.001475232,
0.0127335815,
-0.0040273494,
0.024846012,
0.011997653,
-0.025845254,
-0.0114642745,
-0.004699137,
0.014016392,
0.0077711307,
0.014597032,
0.008939163,
0.0034028236,
-0.013753078,
0.041752104,
-0.00047261437,
-0.0054654474,
0.018067373,
-0.013280463,
0.023455177,
-0.018458966,
0.013449254,
0.013975882,
0.004459454,
0.0017486732,
-0.0041522547,
0.010066686,
0.028491896,
0.00057473284,
-0.030220313,
-0.00023799509,
0.03375817,
-0.007575333,
-0.0015992933,
-0.017648771,
-0.008297758,
0.023819765,
-0.02760068,
0.011977399,
-0.022401921,
-0.0011697205,
-0.0014482255,
-0.014934614,
0.022550456,
0.017864823,
-0.0030854966,
0.023239125,
0.021618731,
0.0035547353,
-0.017662274,
0.021348666,
-0.013044157,
-0.01070134,
-0.0071162223,
0.014110914,
0.009553562,
0.012524281,
-0.0052628987,
-0.021848287,
0.0029842223,
-0.027371123,
-0.00880413,
-0.013125177,
0.036296785,
0.039726615,
-0.025143085,
0.0034078872,
-0.00004293617,
-0.0054485686,
0.03202975,
-0.008243745,
-0.019228654,
0.013550529,
0.029518144,
-0.0010735098,
-0.008682601,
0.000940165,
0.038916416,
-0.012227209,
0.0061203563,
0.00785215,
0.013577536,
0.022820523,
0.012173196,
0.023981804,
0.002415397,
-0.009978915,
0.008966169,
-0.015447739,
0.071189225,
0.011828862,
0.008763621,
0.044101674,
-0.0014144673,
-0.012834856,
-0.115804024,
-0.031678665,
0.00087264867,
0.02334715,
-0.022631478,
0.019768784,
0.009789869,
0.017054627,
0.0015444362,
0.030598404,
-0.03921349,
-0.018134888,
-0.0039935913,
-0.025683215,
0.022509947,
-0.0020744395,
0.0031985866,
-0.025764234,
-0.031759687,
0.03251587,
0.0019090244,
-0.00752132,
-0.005830036,
-0.01710864,
0.028302848,
0.0074943136,
-0.037566092,
0.018850561,
0.0074943136,
0.00017016227,
0.01578532,
-0.01967426,
0.02256396,
0.0077171177,
-0.027789725,
-0.0027681699,
0.001937719,
-0.015920352,
0.027411634,
-0.021740261,
0.0033336193,
0.02202383,
0.0096413335,
-0.031084523,
0.022145359,
-0.0138408495,
-0.016352458,
0.0355406,
0.035108496,
-0.015542261,
-0.025386143,
-0.022942051,
-0.029599164,
0.0075483266,
0.019944327,
0.0026618317,
-0.00027280822,
0.026682457,
-0.028032783,
-0.004310918,
-0.0064815683,
-0.012375745,
0.014934614,
-0.0014819836,
0.013570784,
-0.010512294,
-0.024535438,
-0.04607315,
0.026493412,
-0.019903816,
-0.015447739,
-0.008439543,
-0.033812184,
-0.012969889,
-0.013665307,
0.0008245433,
-0.030382352,
-0.030031268,
0.020646496,
0.0025352386,
-0.022050837,
-0.021915803,
0.0039733364,
-0.000060817452,
0.03392021,
0.013651804,
-0.00615749,
-0.009749359,
0.0014701682,
-0.017365202,
0.015474745,
0.038754378,
-0.004773405,
-0.002747915,
-0.019512221,
0.021510705,
-0.00165837,
-0.027276602,
0.015245189,
0.020632993,
-0.008507059,
-0.010741849,
-0.07070311,
0.008054699,
0.021308156,
-0.008918908,
0.009965411,
-0.016460484,
0.003412951,
-0.0036458822,
0.004921941,
0.007339026,
0.012699823,
-0.007764379,
-0.0027901127,
-0.006346536,
-0.0041961404,
-0.005532964,
0.04129299,
0.0028053038,
0.02210485,
0.015596274,
-0.006106853,
0.00065153267,
0.0057456405,
0.011234718,
0.015447739,
-0.020714013,
0.0056477417,
0.016690038,
-0.008871647,
0.00394633,
0.007899412,
-0.04809864,
-0.0009275057,
0.0046485,
-0.009648085,
-0.026493412,
-0.0015140539,
0.017392209,
0.01070134,
0.03054439,
0.013476261,
-0.027006535,
0.01723017,
0.0070689605,
-0.0057625193,
0.009074196,
-0.014732065,
0.012085425,
0.0045978627,
-0.0010465032,
0.033569124,
0.0049489476,
0.0030297956,
-0.023050077,
-0.037566092,
-0.0038011698,
0.0034737156,
-0.0022010326,
0.00021119954,
0.0016921283,
0.031597648,
0.042751346,
-0.0058772974,
-0.016230928,
-0.010984908,
-0.004206268,
-0.020781528,
-0.023725241,
-0.008459797,
-0.027182078,
-0.005438441,
0.0109106405,
0.0037404052,
0.0077238693,
0.013314222,
0.0034399575,
0.001144402,
0.008561072,
-0.024602953,
0.025305124,
0.009026934,
-0.0055059576,
-0.016001372,
0.004425696,
0.017675778,
-0.0068630357,
-0.007379536,
0.03913247,
-0.016987111,
-0.01826992,
-0.007676608,
0.0139488755,
0.017378706,
0.019890314,
0.017014118,
0.012044915,
0.0034804672,
0.0047599017,
0.034919452,
0.033001985,
0.0004388562,
-0.036350798,
0.0013748015,
-0.03243485,
-0.007399791,
0.014272954,
-0.035486586,
-0.03732303,
0.00450334,
-0.009897895,
0.041995164,
0.0026111945,
-0.010566307,
0.009533307,
-0.016190417,
0.0041522547,
-0.0028002402,
0.0011688767,
-0.008864895,
0.03751208,
0.027128065,
0.008351771,
-0.0024305882,
-0.018067373,
0.0046721306,
-0.0008279191,
0.015960863,
-0.017419215,
0.025116079,
-0.015852837,
0.009749359,
0.009600824,
-0.047423474,
0.0026989656,
-0.008986425,
0.0004114277,
0.004864552,
0.014286458,
-0.00008977563,
0.08426039,
0.00880413,
-0.030139294,
-0.0058874246,
-0.023617215,
0.018418457,
0.019782288,
0.0019613497,
0.0070149475,
-0.025426652,
0.0110794315,
-0.031462613,
0.003023044,
-0.03054439,
-0.024927033,
0.014070405,
-0.0066706142,
0.024305882,
-0.019552732,
-0.009492797,
0.016095895,
0.0053202873,
0.002228039,
0.020781528,
-0.0318137,
0.0042197714,
0.027843738,
0.0043075425,
0.03656685,
-0.012861863,
-0.004077987,
-0.02661494,
-0.035135504,
-0.024764992,
0.0053000324,
-0.017513739,
0.008905405,
-0.035675634,
0.035432573,
0.03508149,
-0.017932339,
0.02252345,
-0.00085112784,
-0.021173123,
0.00091737823,
-0.006491696,
-0.010343503,
-0.026682457,
-0.009351013
] |
Naive and primed pluripotency is characterized by distinct signaling requirements, transcriptomes, and developmental properties, but both cellular states share key transcriptional regulators: Oct4, Sox2, and Nanog. Here, we demonstrate that transition between these two pluripotent states is associated with widespread Oct4 relocalization, mirrored by global rearrangement of enhancer chromatin landscapes. Our genomic and biochemical analyses identified candidate mediators of primed state-specific Oct4 binding, including Otx2 and Zic2/3. Even when differentiation cues are blocked, premature Otx2 overexpression is sufficient to exit the naive state, | [
-0.013826095,
-0.010460091,
-0.003915829,
-0.017446896,
-0.023615668,
0.0050423,
-0.026901208,
0.015167132,
-0.034276914,
-0.017111637,
0.012713034,
-0.0013091877,
-0.016964123,
0.010030959,
-0.006209003,
-0.011747487,
0.011418933,
-0.021657752,
-0.0026435198,
0.019686427,
-0.047204513,
0.0059542055,
-0.007892004,
-0.03886326,
-0.017084815,
-0.0052233404,
0.0016343893,
-0.037200376,
-0.017232329,
-0.023427922,
0.019512093,
0.029476,
-0.021885728,
-0.0045729373,
-0.014040661,
-0.0124045955,
0.0006877007,
-0.0329627,
0.007375705,
0.0044555967,
0.013866326,
0.035161998,
-0.008689921,
0.0022579716,
0.0020417294,
0.005401028,
-0.013443899,
0.008575934,
-0.013618234,
0.023293817,
0.013061703,
-0.0027474503,
0.00844183,
0.010426565,
-0.032909054,
-0.014778231,
-0.00511941,
0.010527143,
0.0016846781,
0.00341294,
-0.009863329,
0.008119981,
-0.011485985,
0.018036952,
-0.0082742,
0.014349099,
-0.018291749,
0.015220773,
0.019337758,
0.0028681436,
0.025439478,
0.025989303,
-0.0157706,
-0.00592068,
0.0082742,
-0.0063095805,
-0.012304017,
0.0033609748,
-0.015314646,
0.011211072,
0.011110494,
-0.037575867,
-0.016682504,
0.021684574,
0.0073488844,
0.0014617307,
0.012102862,
0.02298538,
0.028322708,
-0.018238107,
0.042162213,
0.04028476,
0.06522805,
-0.0021573938,
0.0019797063,
0.00673536,
0.008528997,
0.0244337,
-0.015529213,
-0.027182827,
-0.024929883,
0.011512806,
-0.015757188,
-0.01310864,
-0.031568017,
0.009588417,
0.007979172,
0.010439975,
0.015556033,
0.0034213215,
-0.019284116,
0.012263786,
-0.01909637,
-0.062653266,
0.02049105,
-0.017916258,
-0.016870249,
0.011995579,
-0.02192596,
-0.018895216,
0.024715317,
0.021993011,
-0.0037079682,
-0.0248226,
0.0019210359,
0.01581083,
-0.0040666955,
-0.0075366297,
-0.039292395,
-0.004616521,
0.017822387,
0.005900564,
-0.0029938659,
0.023803413,
-0.012485057,
0.006091662,
-0.009119053,
-0.018841574,
-0.012297312,
-0.033204082,
-0.0007664866,
0.0072684223,
-0.010942864,
-0.005183109,
0.01724574,
-0.0008465298,
0.017057994,
0.000853235,
0.038648695,
0.012163209,
0.0010460091,
-0.014416151,
0.036368933,
0.0010929455,
0.010507028,
0.03880962,
0.01543534,
0.019619375,
-0.023106072,
-0.00880391,
-0.0019445041,
-0.0031128828,
0.004804266,
0.01795649,
-0.0075500403,
0.022113705,
-0.0023535206,
0.0100644855,
0.0049953638,
-0.02258307,
-0.018613597,
0.0032419576,
-0.046614457,
0.016239962,
0.0050724735,
-0.0070203305,
-0.0011901706,
0.012062631,
-0.01905614,
-0.022100294,
-0.0041773315,
0.0073220637,
0.0052032247,
0.011304945,
-0.016923891,
-0.010621016,
0.020303305,
-0.029476,
-0.017044583,
-0.0072550117,
-0.0022043302,
0.00566253,
0.0032335762,
0.015569443,
-0.6286783,
-0.017473716,
0.0148050515,
-0.032855414,
0.0031581428,
0.052407738,
-0.003932592,
-0.0050724735,
-0.018774522,
0.032748133,
-0.04202811,
-0.0069666887,
-0.0029301664,
-0.019364579,
-0.010507028,
-0.027947217,
-0.011237892,
-0.01114402,
0.0438251,
-0.002361902,
-0.01869406,
-0.013879736,
-0.008857551,
0.03773679,
-0.012250376,
0.016414296,
0.023092663,
-0.011553036,
0.0024155434,
0.039346036,
-0.01834539,
0.009246453,
0.004160568,
-0.005977674,
0.046775382,
0.006430274,
-0.02942236,
0.03738812,
0.011284829,
0.029690566,
-0.014107713,
0.010232115,
0.02842999,
0.019015908,
-0.009729226,
0.015542623,
0.0071007926,
0.008267495,
-0.0027759473,
0.0031112065,
0.02553335,
0.009098938,
-0.013350027,
0.009642058,
0.012666098,
0.0074226414,
0.019954635,
0.000791212,
0.018828165,
-0.022046654,
-0.0065576723,
0.00038806268,
-0.015140311,
-0.026297743,
-0.0019562382,
0.008528997,
-0.00430473,
0.0031011489,
-0.007000215,
-0.0057161716,
0.01114402,
0.041491695,
-0.0010091306,
0.00421421,
0.013557888,
0.042564522,
-0.010030959,
0.011036737,
0.0116938455,
0.032506745,
0.00773108,
-0.020812899,
-0.015998576,
0.004663457,
0.026807336,
-0.010285757,
-0.025640633,
0.019887583,
-0.0070605613,
-0.006628077,
0.014349099,
-0.00029565682,
-0.027129184,
-0.043342326,
-0.02476896,
0.018466083,
-0.0030726518,
0.0179699,
0.00063154474,
-0.017473716,
-0.016079037,
0.0012915866,
0.027920397,
0.017004354,
0.020651974,
0.01471118,
-0.017071405,
0.00090687646,
0.051710397,
-0.013162281,
0.010144947,
0.00087418867,
-0.014442972,
-0.017728513,
-0.0009328591,
-0.016602041,
0.01061431,
0.021295672,
-0.018144235,
-0.014469793,
0.015193953,
-0.027156005,
-0.0049853064,
0.010352808,
0.0010141594,
0.011036737,
0.009011771,
-0.013879736,
0.0071142027,
0.007436052,
0.0021221915,
-0.01547557,
0.024406878,
-0.015167132,
0.0155158015,
-0.007436052,
0.0070404457,
0.007791427,
0.022019833,
-0.0072818324,
-0.041491695,
-0.0028580858,
-0.0043214927,
-0.034732867,
-0.018291749,
-0.017728513,
-0.013685286,
0.011110494,
-0.0048746704,
-0.013021472,
0.0113384705,
-0.00014028508,
-0.01909637,
0.0020987233,
0.007375705,
0.001994793,
-0.0073421793,
-0.031728942,
0.00053012883,
-0.0042745564,
-0.01149269,
0.032426283,
-0.00052300456,
-0.00012938914,
-0.0031212643,
-0.013209217,
-0.0023484917,
0.01727256,
-0.0036945578,
-0.03349911,
-0.004096869,
-0.0056021833,
-0.025734507,
-0.0032453104,
-0.0125386985,
0.01076853,
-0.0066582505,
-0.006571083,
0.008032814,
-0.009816393,
-0.0047673876,
-0.010728299,
-0.02444711,
-0.01622655,
0.03639575,
-0.0019830589,
0.019002499,
0.009259863,
0.010372924,
0.02476896,
-0.00136702,
0.021282261,
-0.0129678305,
0.032935876,
0.009313504,
-0.029046869,
0.006926458,
0.005689351,
-0.013370142,
0.01401384,
0.004747272,
-0.0007132642,
-0.0058636856,
-0.025613813,
0.00014175184,
-0.023414511,
0.0061855344,
-0.011921822,
-0.016280193,
0.017299382,
0.0024557747,
-0.014858694,
0.0024926532,
-0.022703761,
0.00027742708,
0.0034732867,
-0.01076853,
0.0011893325,
0.0014944185,
-0.013638349,
0.0004215886,
-0.014603896,
0.005893859,
0.0077646063,
-0.0079322355,
0.0058670384,
0.0068862266,
-0.0008096513,
0.0057295817,
-0.0017869322,
-0.012485057,
0.015314646,
0.0056424146,
-0.01833198,
0.021993011,
0.01619973,
0.006899637,
-0.021657752,
0.017943079,
-0.008857551,
-0.008301021,
0.018425852,
0.011184251,
0.0136785805,
-0.01830516,
-0.005696056,
0.0474459,
0.0020132323,
-0.022891507,
0.0026183755,
-0.018104004,
0.00091944874,
-0.01762123,
0.002542942,
0.012672802,
-0.008515587,
0.0010560668,
-0.00070991163,
0.022153936,
0.035457026,
0.020987233,
-0.01904273,
-0.0019042729,
-0.012176619,
0.0054613743,
-0.023092663,
0.008482061,
0.007141024,
-0.022569658,
-0.01866724,
-0.0114122275,
0.025372425,
0.022945149,
-0.011137315,
-0.015046438,
0.008099865,
-0.004385192,
-0.0056256517,
0.0058838013,
-0.00096387055,
-0.00350346,
-0.008126686,
0.028885944,
0.03591298,
-0.011392112,
-0.0063028755,
-0.021496829,
-0.013443899,
-0.012827022,
-0.000361661,
0.0040264647,
-0.006899637,
-0.016762966,
0.0042410307,
-0.007375705,
-0.021765037,
0.011150725,
-0.008126686,
0.014349099,
-0.037575867,
0.023106072,
-0.014442972,
-0.015274415,
-0.0008599402,
0.02912733,
0.0027424213,
-0.00234011,
-0.013048293,
-0.002547971,
-0.019230476,
-0.005256866,
-0.009132464,
0.003929239,
-0.018895216,
-0.0006302875,
0.0035671592,
0.0025747917,
0.016213141,
0.03164848,
-0.0013284651,
-0.0060782516,
-0.016253373,
-0.0027474503,
0.014335689,
0.029234614,
0.023132894,
-0.0022361798,
0.026391614,
-0.022153936,
0.00575305,
-0.01546216,
-0.0035571014,
0.015046438,
-0.011371996,
-0.0071812547,
0.013698696,
0.009722521,
-0.0022847923,
0.018613597,
0.023199946,
-0.0022395323,
-0.037629507,
-0.019082962,
-0.004073401,
0.0070538563,
-0.016695915,
-0.0018824812,
0.027544906,
0.002142307,
-0.0050724735,
0.018439263,
0.021966191,
-0.0026435198,
-0.0050154794,
-0.013879736,
0.031004783,
-0.00068351,
-0.0059542055,
0.012974536,
-0.04092846,
0.01652158,
0.033606395,
-0.009306799,
0.018586777,
0.012726444,
0.008562523,
0.009870035,
-0.02556017,
0.0041203373,
0.014080891,
-0.004401955,
0.0033710327,
-0.014657537,
-0.023065843,
0.010051074,
-0.017862616,
-0.020316714,
-0.0016821637,
-0.001299968,
0.008817321,
0.015167132,
-0.019297527,
0.0007396659,
-0.01402725,
-0.004234325,
-0.031138886,
0.02373636,
-0.020745847,
0.002345139,
-0.0359398,
-0.013826095,
-0.0052970974,
-0.010124831,
-0.009139169,
0.0065409094,
-0.008797205,
-0.050449822,
0.0061721243,
0.016776377,
0.034089167,
0.012257081,
0.0012404595,
0.002876525,
0.029771028,
0.0063598696,
-0.019847352,
0.006584493,
-0.011298239,
0.015247595,
-0.019284116,
0.013014767,
-0.01022541,
-0.004807619,
0.0015136958,
0.017554179,
-0.021751625,
0.02045082,
0.0064570946,
0.0017039556,
0.02153706,
0.027759472,
0.027209647,
-0.0056658825,
0.00031556285,
-0.0061453036,
-0.031568017,
-0.0030156577,
-0.021657752,
-0.004368429,
-0.013537772,
0.004740567,
0.0026720169,
-0.041920826,
-0.021040875,
0.02122862,
-0.02297197,
0.002542942,
0.0022697058,
0.024245955,
0.018922037,
0.01472459,
0.043261863,
-0.0077646063,
-0.009266567,
0.0010912691,
-0.011237892,
0.01685684,
0.020236254,
-0.022167347,
0.0074762832,
-0.00030215248,
-0.006832585,
-0.02765219,
0.007918825,
0.0048679654,
0.01909637,
-0.0037046156,
-0.011848065,
0.0016125974,
0.022153936,
-0.000108749744,
0.006708539,
0.0017215566,
-0.01727256,
-0.0027156007,
0.0023216708,
-0.0015329733,
-0.034786507,
0.011150725,
-0.029154152,
-0.0047942083,
0.010828876,
0.018492905,
0.007650618,
-0.010694773,
0.010862403,
-0.022100294,
-0.012686213,
-0.011834654,
-0.036181185,
0.008046224,
-0.03449148,
0.03266767,
0.011452459,
0.03376732,
0.011459163,
0.016266782,
0.034840148,
0.0022177405,
-0.00771767,
0.0007254174,
0.02334746,
-0.023816822,
0.008770384,
-0.0127599705,
0.009367146,
0.016695915,
-0.014791641,
0.011365292,
0.038648695,
-0.015663316,
-0.020625154,
0.017446896,
-0.03703945,
-0.02985149,
0.014992797,
-0.010453386,
-0.00005814654,
-0.029395537,
0.014791641,
0.014429562,
0.016320424,
0.014939155,
-0.0023082604,
0.01760782,
-0.0060246103,
0.014362509,
0.0029452532,
-0.0031933452,
-0.020263074,
0.0033995295,
-0.013484131,
-0.022542838,
0.00045134287,
-0.00007433328,
0.023025611,
0.0047606826,
-0.0012505173,
-0.015703548,
0.019150013,
-0.02767901,
-0.032184895,
-0.026659822,
-0.018533135,
-0.011546331,
-0.008649691,
-0.02153706,
-0.029610103,
-0.006775591,
-0.014349099,
-0.03661032,
0.015529213,
-0.019793712,
-0.03996291,
0.020008277,
0.0006453742,
0.021765037,
-0.0004176074,
0.01721892,
0.013759043,
-0.009628648,
-0.01650817,
-0.021107927,
-0.021456597,
-0.005380912,
0.056269925,
0.002774271,
-0.0052769817,
-0.002774271,
0.016843429,
0.0007040446,
-0.0049886587,
-0.02411185,
-0.012304017,
0.007214781,
-0.018157646,
0.0011457488,
0.009702405,
-0.023629077,
0.024701908,
-0.014992797,
0.003915829,
-0.00700692,
-0.005907269,
-0.021335904,
0.02444711,
-0.004656752,
0.012176619,
0.021349315,
0.008247379,
0.007878594,
-0.014121123,
0.015033028,
0.0034162926,
-0.0009404024,
0.019579144,
-0.032131255,
0.0069465735,
0.022167347,
0.028081322,
-0.024527572,
0.008207148,
0.026834156,
0.040794354,
-0.0051428783,
-0.005340681,
0.0074159363,
0.023924105,
0.021174978,
-0.0024540983,
0.0016327129,
-0.019699838,
-0.037790433,
0.010473502,
0.010332692,
0.0049853064,
0.01400043,
-0.020035097,
-0.017849207,
-0.0060078474,
-0.016213141,
-0.031433914,
-0.0019931167,
-0.03698581,
-0.004753977,
0.007523219,
0.027759472,
0.010580785,
-0.0009228013,
-0.0052233404,
-0.00051378494,
0.023883875,
-0.013222628,
0.019874172,
0.016333835,
0.0052769817,
-0.037924536,
0.011774308,
-0.009300094,
-0.023253586,
0.009400671,
-0.03765633,
-0.022127116,
0.015958345,
0.0077713113,
0.024527572,
0.011499395,
0.012733149,
0.003282189,
-0.0022579716,
0.005629004,
-0.0060313153,
-0.0125386985,
0.014349099,
-0.01689707,
-0.012371069,
0.010875813,
-0.007288538,
-0.0004526001,
-0.0077713113,
-0.01295442,
0.034276914,
-0.033525933,
0.0095012495,
-0.011291535,
0.004948428,
-0.0047673876,
-0.010037664,
0.0072013703,
-0.00987674,
-0.0071745496,
0.0007136833,
-0.013973609,
-0.0011206043,
-0.0359398,
0.0027156007,
0.016038807,
0.004821029,
-0.010902633,
-0.010124831,
-0.0032972754,
-0.029931953,
-0.036315292,
0.02014238,
-0.027786294,
0.030200161,
0.0143893305,
-0.021134747,
-0.022516016,
-0.018506315,
-0.041572157,
-0.016119268,
-0.0051328205,
0.016038807,
0.0077109644,
0.00067429035,
0.0013904881,
-0.01622655,
-0.0018204581,
0.014107713,
-0.013477425,
-0.0061687715,
0.01114402,
-0.009172695,
0.012337543,
0.0041337474,
-0.024862831,
-0.0169373,
0.029261434,
-0.009675584,
-0.0020903419,
0.022784224,
-0.018881805,
0.034303736,
-0.013021472,
0.031192528,
0.01327627,
0.020021686,
0.043664176,
-0.03486697,
-0.0026066413,
0.015059849,
0.010607605,
-0.0035671592,
0.012592341,
-0.011244598,
0.01238448,
0.009387261,
-0.012203439,
-0.011593267,
0.008575934,
-0.010379629,
0.013148871,
0.0051730513,
0.02368272,
0.019619375,
-0.00024411069,
0.003102825,
-0.0127599705,
-0.011599973,
-0.02232827,
-0.008730153,
0.030629292,
-0.013839505,
-0.014456382,
0.0061587137,
-0.023924105,
-0.024742138,
-0.00655432,
0.02008874,
-0.0014189851,
-0.015180542,
0.019351168,
-0.00095297466,
-0.023079252,
0.00539097,
-0.008461946,
-0.0023065843,
-0.011331765,
-0.0027558317,
-0.012277196,
-0.0009730902,
0.0033408592,
-0.018600188,
-0.010144947,
0.009668879,
-0.0075433347,
-0.0063095805,
-0.0064403317,
0.019471861,
0.18871076,
-0.018238107,
0.004566232,
-0.006933163,
0.01975348,
-0.011117199,
0.005256866,
-0.013537772,
-0.010077896,
-0.006789001,
0.008924603,
0.021174978,
-0.011941938,
-0.003939297,
0.003915829,
-0.019579144,
-0.020370357,
-0.0183588,
-0.01872088,
-0.0009144198,
0.02049105,
-0.029556463,
0.027518086,
-0.008844141,
0.038648695,
0.008026108,
-0.020772668,
0.005994437,
-0.0012169913,
0.02008874,
-0.027920397,
0.029744208,
0.002266353,
0.028993227,
0.021174978,
0.011345176,
0.0028044442,
-0.005860333,
0.018224698,
-0.008267495,
0.011331765,
0.014684359,
-0.0112647135,
0.004147158,
-0.009286683,
0.03661032,
-0.005193167,
-0.010580785,
0.005622299,
-0.011734077,
-0.023548616,
0.03776361,
0.011646909,
0.009957202,
0.0039527076,
0.009045296,
-0.0006034668,
0.03698581,
0.000666747,
0.013772453,
-0.00091944874,
0.0033391828,
-0.025586993,
0.006141951,
-0.010151653,
0.010486912,
-0.008857551,
-0.0013879737,
0.01872088,
-0.025761327,
0.013732222,
0.021134747,
-0.017567588,
0.011284829,
-0.0169373,
-0.036932167,
0.04774093,
0.008582639,
0.022757404,
0.004871318,
0.024755549,
0.010848992,
-0.025372425,
-0.01547557,
0.001587453,
-0.032184895,
0.030334264,
-0.01402725,
-0.02047764,
-0.024406878,
0.015623084,
-0.03443784,
-0.023052432,
-0.011211072,
-0.009031886,
-0.009756046,
-0.007576861,
0.014282048,
-0.016830018,
-0.0031631717,
-0.03808546,
0.06372609,
0.016025396,
0.032184895,
0.0037683148,
0.012203439,
0.01904273,
0.0116938455,
0.0011482632,
0.001259737,
0.012029105,
0.008254085,
0.010728299,
-0.01622655,
0.007845068,
0.023977747,
-0.0050624157,
-0.030334264,
0.052756406,
-0.0021624228,
-0.0002661121,
-0.033472292,
-0.0043483134,
0.02581497,
-0.012485057,
0.0037213785,
0.00539097,
0.01583765,
-0.0102119995,
-0.021858908,
-0.011948642,
-0.0059441477,
0.025265142,
0.023092663,
0.011573152,
-0.032506745,
0.008964835,
-0.010674657,
-0.008555818,
0.010500322,
-0.011445753,
-0.0060279625,
0.002035024,
-0.008153507,
0.0034732867,
-0.020182611,
0.024540983,
0.01902932,
-0.01170055,
-0.0031464088,
-0.0019445041,
-0.013403668,
0.017004354,
0.01061431,
0.025265142,
-0.009548185,
-0.0049584853,
-0.032801773,
-0.0027273346,
0.033847783,
-0.026646411,
0.026337972,
-0.002723982,
0.0028899354,
-0.011003211,
-0.010305872,
-0.16875614,
-0.011848065,
0.02910051,
-0.020799488,
0.027088953,
0.02192596,
0.0071343184,
-0.010339398,
0.0047170985,
-0.006638135,
0.026780516,
0.009259863,
-0.033552755,
-0.0107014775,
-0.0007656485,
0.004371782,
-0.006125188,
0.037575867,
0.024916474,
0.009380556,
0.0046936306,
-0.009052002,
0.02121521,
-0.01937799,
0.0133232055,
-0.0015908055,
0.015274415,
-0.0072080754,
-0.0074896934,
-0.030092876,
-0.0083613675,
-0.01080876,
0.01547557,
-0.014268637,
0.018801343,
0.002836294,
0.003751552,
-0.012471647,
-0.0019093018,
0.040097017,
0.010366218,
0.003949355,
-0.0035738645,
0.009762752,
-0.019418221,
0.022207579,
-0.02372295,
-0.002011556,
0.011284829,
-0.003922534,
0.019579144,
-0.014898924,
-0.007261717,
-0.0014717885,
0.029234614,
0.0152341835,
0.0100846,
0.009487839,
-0.005538484,
-0.015006208,
-0.002650225,
0.00386554,
0.055572588,
0.003248663,
-0.0034498186,
-0.015569443,
0.0052803345,
0.03425009,
-0.03371368,
0.0025664102,
0.00067848107,
-0.029931953,
0.022046654,
-0.026633002,
0.020330125,
0.015703548,
-0.010500322,
0.024527572,
-0.0004261984,
0.014858694,
-0.030119698,
0.015261005,
-0.018264929,
-0.010929454,
-0.014282048,
0.0075969766,
0.009943792,
0.03054883,
-0.015958345,
-0.013510951,
-0.003203403,
-0.01022541,
-0.0010091306,
-0.01223026,
0.036851704,
0.026700053,
-0.002480919,
-0.011258008,
-0.00045343823,
-0.010956275,
0.027464444,
-0.012545404,
-0.003577217,
-0.0048411447,
0.03781725,
0.002452422,
-0.018559957,
0.007999288,
0.060132112,
-0.011781013,
0.007583566,
0.00040231118,
-0.017513948,
0.0005724553,
-0.0041806838,
0.047150873,
-0.010433271,
0.008756974,
0.019391399,
-0.035430204,
0.08287611,
0.0010778587,
-0.004351666,
0.023132894,
-0.0067387125,
-0.017312791,
-0.1317435,
-0.021027464,
0.010721593,
0.0050490056,
-0.020182611,
0.013296385,
-0.005974321,
0.04275227,
-0.014845283,
0.032882236,
-0.012920895,
-0.027839934,
0.025345605,
-0.013115345,
0.02046423,
0.009286683,
0.0072348965,
-0.011935232,
-0.015569443,
0.04133077,
-0.020705616,
-0.016830018,
-0.0052937446,
-0.0009412406,
0.029154152,
0.017849207,
-0.034893792,
0.016454527,
0.018184466,
0.010010843,
0.009313504,
-0.027893577,
0.027839934,
-0.008777089,
-0.010661246,
0.011626793,
-0.0030642704,
-0.027625369,
0.027974037,
-0.017808976,
-0.011063558,
-0.010567374,
0.016736146,
-0.013759043,
0.009870035,
-0.00628276,
-0.005541837,
0.010929454,
0.0034095873,
-0.025667455,
-0.05535802,
-0.02191255,
-0.010775235,
-0.0026301094,
0.012176619,
0.004210857,
0.006768886,
0.029020047,
-0.0057664607,
0.0075969766,
0.0036174483,
-0.007000215,
-0.021148158,
-0.005260219,
0.0024339827,
-0.016079037,
-0.022516016,
-0.029261434,
0.021094518,
-0.021966191,
-0.015556033,
0.02837635,
0.021094518,
0.022422144,
-0.022596478,
-0.00898495,
-0.0013879737,
-0.022797635,
-0.006668308,
-0.032989517,
-0.0064403317,
-0.024608035,
-0.0031329985,
0.016427707,
0.027571727,
-0.0039124764,
0.0029687213,
-0.014858694,
-0.0039929384,
0.000069252004,
-0.009615238,
0.04530024,
-0.018801343,
-0.029797848,
-0.013631645,
0.0047875033,
-0.0037381416,
-0.0036208008,
0.027893577,
0.030602472,
0.0007245792,
-0.02303902,
-0.04953792,
0.016588632,
0.014402741,
-0.006799059,
0.008301021,
-0.006044726,
0.0005841894,
-0.030387906,
-0.021081107,
0.0019126545,
-0.028081322,
0.00044338047,
-0.035457026,
0.0000875865,
-0.014617307,
-0.01544875,
0.018492905,
-0.013987019,
0.00071829313,
0.007047151,
0.011331765,
-0.016038807,
0.02227463,
-0.0012538699,
-0.0054915478,
0.0018372211,
-0.01149269,
0.01909637,
-0.0017886085,
0.0028949643,
0.01168714,
-0.04674856,
-0.009635353,
0.013866326,
-0.024876243,
-0.020772668,
0.0022579716,
0.03561795,
0.006135246,
0.03306998,
-0.009655469,
-0.029744208,
0.022864686,
-0.009648764,
-0.012371069,
0.009414082,
-0.026458666,
0.0011164135,
0.018586777,
-0.013484131,
0.045836654,
0.0073891156,
0.009380556,
-0.02842999,
-0.019820532,
-0.019337758,
-0.022234399,
0.009776162,
-0.00048025898,
-0.012961126,
0.030307444,
0.030602472,
0.010580785,
0.003091091,
0.00166121,
-0.016722735,
-0.023977747,
0.0013552859,
0.013517656,
-0.023173125,
-0.009447608,
0.0032922465,
0.010426565,
0.013698696,
0.014094302,
-0.018881805,
-0.010842287,
0.010513732,
-0.037790433,
0.032050792,
0.008582639,
0.002774271,
-0.011392112,
0.013396963,
0.040499326,
-0.014684359,
-0.03805864,
0.012344249,
-0.020544691,
-0.0020266427,
-0.013759043,
-0.0018288397,
0.0049115494,
-0.0076237973,
-0.00072667457,
0.017688282,
-0.0074963984,
0.030092876,
0.0010325988,
0.010902633,
-0.004418718,
0.017795565,
0.024004567,
-0.04135759,
-0.015421929,
0.02232827,
-0.037790433,
-0.033686858,
0.004522648,
-0.0050657685,
0.011713961,
0.00009602037,
-0.0021942724,
0.002051787,
-0.03492061,
0.0050054216,
-0.020719027,
-0.029207792,
-0.014858694,
0.034840148,
0.022100294,
0.013128756,
-0.0069532786,
-0.009253157,
0.015891293,
-0.021081107,
0.03918511,
-0.0031916688,
0.019874172,
0.0048176767,
0.025251733,
0.017339613,
-0.0025161214,
-0.014456382,
-0.018546546,
-0.0007606196,
0.0011315002,
0.027544906,
-0.00068183366,
0.08571911,
0.016307013,
-0.03191669,
-0.01976689,
-0.005447964,
0.03980199,
-0.0013158929,
0.021738214,
-0.01830516,
-0.008522292,
0.03559113,
-0.032882236,
0.021604111,
-0.015944934,
-0.0057832235,
0.0183588,
-0.025788147,
0.0077847214,
-0.0152341835,
-0.003677795,
0.0059475005,
-0.018130824,
-0.005340681,
0.012531994,
-0.051227625,
-0.0069800992,
0.026820747,
-0.011023327,
-0.00234011,
-0.010091306,
0.008307726,
-0.008126686,
-0.046507172,
-0.0064336266,
0.0038957135,
-0.0029251375,
-0.019726658,
-0.009930382,
0.039265573,
0.019579144,
-0.006356517,
-0.0055787154,
-0.0083613675,
-0.0017601114,
0.027974037,
-0.015582854,
0.0032788361,
-0.010775235,
-0.015341467
] |
The effects of topoisomerases I and II on the replication of SV40 DNA were examined using an in vitro replication system of purified proteins that constitutes the monopolymerase system. In the presence of the two topoisomerases, two distinct nascent DNAs were formed. One product arising from the replication of the leading template strand was approximately half the size of the template DNA, whereas the other product derived from the lagging template strand consisted of short DNAs. These products were synthesized from both SV40 naked DNA and SV40 chromosomes. For the replication of SV40 naked DNA, either topoisomerase I or II maintained replication | [
-0.031773597,
-0.013269993,
-0.020496095,
-0.023059767,
-0.037671372,
0.02522494,
-0.009231877,
-0.0034005188,
-0.018822402,
-0.027230715,
0.008587638,
0.012506205,
0.0020738514,
0.0049446994,
-0.0024109145,
0.021279808,
0.013250068,
-0.0070334948,
-0.013920873,
-0.00019841894,
-0.029993638,
0.016962744,
-0.007684375,
-0.023458265,
-0.00006558617,
0.0035101057,
0.021718156,
-0.029090375,
-0.020217147,
0.006920587,
0.00067288097,
-0.017148709,
-0.010845795,
-0.00044498974,
0.0005587278,
-0.009065836,
0.009019344,
-0.0056055426,
0.008069591,
-0.02765578,
-0.00275628,
0.020522662,
-0.012765229,
0.000023414368,
-0.02858561,
0.02238232,
0.014252955,
-0.008169215,
-0.0010286237,
0.019274034,
0.013641925,
0.019579548,
-0.023006635,
0.015966497,
-0.01475772,
-0.014970252,
0.014359222,
0.01192174,
0.0059509077,
-0.011622867,
-0.008939645,
-0.0021137013,
-0.010261331,
0.013788041,
-0.02858561,
0.015196068,
0.013123876,
-0.0033158378,
0.013655208,
-0.0017733173,
0.04014206,
0.022807386,
-0.018344205,
0.0047985837,
0.013801324,
-0.028532477,
-0.022528436,
-0.019074785,
0.012140915,
0.015581283,
0.011377126,
-0.0063759726,
0.0019011688,
-0.004167628,
0.004639184,
0.0003729695,
0.0042274026,
0.01987178,
0.0016770136,
-0.012605829,
0.02412243,
0.03158763,
0.02169159,
0.014306088,
-0.04091249,
0.02473346,
0.0050343615,
0.04216112,
-0.04367541,
-0.025264792,
-0.019818649,
-0.023046484,
-0.0008318652,
-0.013323126,
-0.0045628054,
0.017201843,
0.02566329,
-0.033234756,
-0.0006936361,
-0.021744723,
-0.03751197,
0.01552815,
0.011895174,
-0.021279808,
0.019513132,
-0.012552696,
0.023351999,
-0.014970252,
-0.0015358787,
0.003211232,
0.005671959,
0.02019058,
0.035147548,
-0.036874376,
0.04269245,
-0.0028824708,
-0.015421883,
-0.011224369,
-0.004911491,
0.016670512,
0.034084886,
0.025052259,
0.019486567,
-0.0038255835,
0.007046778,
0.008003174,
0.0026002014,
-0.034403685,
-0.008866587,
-0.03004677,
0.016763495,
0.015979782,
-0.0031116074,
-0.010812587,
0.008806812,
-0.0035632388,
0.007903549,
0.010600055,
0.013814608,
-0.0038289044,
0.0036362968,
-0.03190643,
0.01880912,
-0.022860518,
0.016006349,
0.040221762,
-0.0035300306,
0.02230262,
-0.038946565,
-0.010938778,
-0.0015848608,
-0.0019692457,
0.012665604,
0.004313744,
-0.00579815,
0.022926934,
-0.0021934009,
0.011217726,
0.014213106,
-0.023830198,
-0.0119881565,
-0.009982382,
-0.053265937,
0.026632968,
-0.01706901,
0.0017085614,
0.004679034,
0.0027230717,
0.0025570306,
-0.03615708,
-0.009265085,
-0.010892287,
0.01690961,
0.010267972,
-0.0309766,
-0.0027961296,
-0.009763208,
-0.009072478,
0.0041875527,
0.005539126,
-0.01536875,
-0.0024424624,
0.004333669,
0.0098561905,
-0.63759726,
-0.028266812,
-0.016404847,
-0.04014206,
0.006913945,
0.020496095,
0.006369331,
0.022010388,
-0.010573488,
0.041868888,
-0.01115131,
-0.010341031,
0.026154771,
-0.032783125,
-0.041178156,
-0.033659823,
0.015049952,
0.0033540272,
0.011450184,
0.0019974727,
-0.037166607,
0.0053465185,
0.010812587,
0.023099618,
0.002238232,
-0.010892287,
0.04322378,
-0.027310416,
-0.002578616,
0.035944544,
-0.022475304,
0.028851276,
-0.018105105,
-0.008620846,
0.03397862,
-0.007943399,
0.010626621,
0.016444696,
0.029781105,
0.029967071,
-0.011184518,
-0.0018696211,
0.003239459,
-0.00012172877,
-0.0034935016,
0.0087470375,
0.000070048525,
0.01617903,
0.00880017,
0.0076644504,
0.0057317335,
-0.0042672525,
-0.010679754,
0.006023966,
0.01845047,
0.018941952,
0.009311576,
-0.016617378,
0.015740681,
0.011629508,
0.0030219452,
0.02388333,
-0.022727685,
-0.0072792354,
-0.017666757,
0.00903927,
-0.013269993,
0.0048284708,
-0.0004885755,
-0.0016404846,
0.014332655,
0.029116942,
0.009032628,
-0.019725665,
-0.018131671,
0.04516314,
0.0018945272,
0.0231129,
0.0066349963,
0.0022365716,
0.01738781,
-0.016843194,
-0.029276341,
-0.0041709486,
0.022873802,
-0.021226676,
-0.042320516,
0.00932486,
-0.01779959,
-0.025371058,
0.00078952475,
0.015926648,
-0.020934444,
-0.030232737,
-0.027735481,
0.034642786,
0.008321973,
0.0029538686,
-0.010075365,
-0.027310416,
0.012997686,
-0.010553563,
-0.0011747397,
-0.005485993,
-0.0042738942,
0.010626621,
-0.029409174,
0.0009505844,
0.04917469,
-0.011463467,
0.0016288618,
-0.009716717,
-0.009723358,
-0.001334139,
-0.016032914,
-0.019154483,
0.008707187,
-0.001917773,
-0.0092584435,
-0.025331208,
0.0023860084,
-0.016205598,
-0.009431126,
0.009836266,
0.0069670784,
0.0006986173,
-0.0024474435,
-0.017666757,
0.00042444217,
-0.011038402,
-0.0023976313,
0.009025986,
0.027018184,
-0.017241692,
0.0037757712,
-0.0050708908,
0.007684375,
0.010978628,
-0.00042963095,
-0.039477896,
-0.022515154,
0.0012519488,
-0.006312877,
0.008700546,
-0.0020506058,
-0.02988737,
-0.011815474,
-0.0026466928,
0.014292805,
0.010287898,
0.0044498974,
-0.0014744437,
-0.010374239,
0.0028592253,
0.0066881296,
0.007305802,
-0.00017247503,
-0.04253305,
-0.012658962,
-0.010812587,
0.006538693,
0.02003118,
-0.016311863,
0.0061567985,
-0.007372218,
-0.011888532,
0.0119615905,
-0.01451862,
-0.007046778,
-0.03751197,
-0.00038791317,
-0.0011249274,
-0.0016147483,
-0.0129844025,
0.0018829044,
0.022236204,
0.01475772,
0.006681488,
0.013362976,
0.013881024,
-0.002469029,
-0.002379367,
-0.011881891,
-0.008016457,
0.03634304,
0.004918133,
0.06349406,
-0.03307536,
0.005655355,
0.03721974,
0.010048798,
0.008607563,
0.0037326005,
-0.012134273,
0.019792082,
0.0021917406,
0.0009887739,
0.021479057,
0.01078602,
0.005864566,
0.009437768,
-0.008933003,
-0.008401672,
-0.0192209,
0.011456826,
-0.015979782,
0.009006062,
-0.015063236,
0.00863413,
0.0087470375,
0.0050177574,
-0.005246894,
-0.0026085034,
-0.01726826,
-0.0022797422,
0.022036955,
0.0045295972,
0.013562225,
-0.01030118,
0.02169159,
-0.0310563,
-0.0021137013,
0.017254977,
-0.0234317,
-0.0014038762,
0.004957983,
-0.0038986416,
0.0058944537,
-0.0049779075,
0.012599187,
-0.012685529,
-0.0104805045,
0.02088131,
-0.0077839997,
0.018795835,
0.041496955,
0.010221481,
0.0067811124,
0.037777636,
-0.012539413,
-0.008727113,
0.0034602934,
-0.0051273447,
-0.014784287,
0.03668841,
0.019778797,
0.023298867,
0.017666757,
-0.008939645,
0.013841174,
-0.005485993,
0.0025038975,
-0.025742989,
0.007139761,
0.014425638,
0.005539126,
0.01876927,
0.013236784,
0.030631235,
0.018795835,
0.0076777334,
-0.011184518,
0.012014723,
-0.013814608,
-0.011695924,
0.005207044,
0.0025653327,
-0.003981662,
-0.0054461434,
-0.0051240236,
0.0064855595,
0.014744436,
0.01764019,
-0.005818075,
0.0112775015,
0.0057715834,
0.0007065043,
0.011496675,
0.012745303,
0.02023043,
-0.027071318,
-0.045960136,
0.032809693,
-0.0059575494,
0.012698812,
-0.01001559,
-0.007983249,
-0.014186539,
0.011496675,
0.017135426,
0.00021315507,
0.0028940937,
0.011144669,
0.01892867,
-0.022940218,
-0.024839727,
0.026579836,
-0.03158763,
0.019552983,
-0.033234756,
-0.0006093703,
0.023338716,
-0.0060604946,
0.0029953788,
0.04322378,
-0.0051074196,
0.0035632388,
0.007916832,
0.009351427,
-0.020655494,
0.028373078,
-0.00011041723,
-0.015753966,
-0.000036814392,
-0.012911344,
-0.008527863,
-0.0072925184,
-0.017095577,
0.005266819,
-0.015142934,
-0.013323126,
-0.02258157,
0.00049231143,
-0.007883624,
0.013469242,
0.025317924,
0.003925208,
0.0017102218,
0.012413221,
-0.002322913,
0.009138894,
-0.01483742,
0.025490606,
-0.03020617,
0.012519488,
-0.023936464,
0.018875536,
0.010819228,
0.0039783414,
0.018835686,
0.0056619965,
-0.031561065,
0.0050742114,
0.0015533131,
-0.008328614,
0.024786593,
0.026300887,
0.03977013,
0.0030601348,
0.005525843,
0.021439208,
0.02416228,
0.0038255835,
-0.02522494,
-0.021797856,
0.011390409,
0.0012544394,
0.032065827,
-0.00022519304,
-0.033766087,
-0.0057549793,
0.018304355,
0.0056254673,
0.0021950614,
-0.0010385861,
-0.0015748984,
0.011171235,
-0.0018878856,
0.01459832,
-0.004406727,
0.0016894666,
0.0058379997,
-0.017281542,
-0.00089745136,
0.01009529,
-0.01078602,
-0.014013857,
-0.007505051,
0.0012834965,
0.0014287824,
-0.008833379,
-0.026579836,
-0.021226676,
0.012625754,
-0.009172102,
-0.022687836,
0.013157085,
-0.0013615359,
0.010101931,
-0.020854743,
-0.013157085,
-0.017733173,
-0.0026832218,
-0.017334675,
0.004383481,
-0.023179317,
-0.04046086,
-0.0089462865,
0.029329473,
0.024175562,
-0.0017301467,
-0.008913078,
-0.02230262,
0.0126722455,
-0.0071331193,
-0.026818935,
-0.008142648,
-0.03198613,
-0.02299335,
0.028532477,
0.0030385493,
-0.010194914,
-0.010832512,
-0.013455959,
0.004679034,
-0.0009920946,
0.020124163,
-0.009563959,
0.005778225,
0.019858498,
0.018144956,
0.041709486,
0.0037558463,
-0.013641925,
-0.0046657505,
-0.048351124,
-0.009006062,
-0.028877843,
-0.019858498,
-0.0060106823,
-0.0192209,
0.014279522,
-0.022980068,
-0.020389829,
0.0071264775,
-0.019260751,
-0.0044698226,
0.0017052406,
0.026447004,
0.031959563,
0.000977151,
0.011602942,
-0.013548941,
-0.0030186246,
0.00046283915,
-0.011031761,
0.032809693,
-0.0079500405,
-0.015249201,
0.00851458,
0.034403685,
-0.040753093,
-0.0058678873,
0.006296273,
-0.010553563,
0.0023627628,
0.0051970817,
-0.00903927,
-0.007923475,
-0.007843775,
0.0052834232,
-0.0055656927,
0.019951481,
-0.016630663,
0.0050376826,
0.0015616152,
0.0008708848,
-0.00013802154,
-0.004934737,
-0.019367017,
0.012207331,
0.032278363,
-0.014106839,
-0.0046192594,
-0.0019808686,
-0.0017716569,
-0.03437712,
0.0092584435,
-0.021359509,
-0.056321092,
-0.015740681,
-0.002072191,
0.016285297,
0.022873802,
0.032623727,
0.009982382,
-0.0025454077,
0.022767534,
0.010228123,
-0.004350273,
-0.0022598174,
0.01706901,
-0.009444409,
0.017812874,
0.029409174,
0.004124457,
0.023298867,
-0.0059575494,
0.024706895,
0.019566266,
-0.0018679607,
-0.013881024,
0.017852724,
-0.026035221,
-0.0022498548,
-0.010593412,
-0.004463181,
-0.0012029667,
-0.024587344,
-0.0048683207,
0.010035515,
0.0051871194,
0.023976313,
-0.012738662,
0.03174703,
0.015342184,
0.016484546,
-0.020124163,
-0.003709355,
-0.016072765,
0.014983536,
-0.022820668,
-0.0029737935,
0.01317701,
-0.011563092,
-0.0030883618,
0.010042157,
-0.023259016,
-0.0063361228,
0.016019631,
-0.02205024,
-0.032012697,
-0.013090668,
0.0056254673,
0.0134626,
0.002575295,
-0.010812587,
-0.01987178,
-0.0025537098,
-0.0056619965,
-0.013469242,
0.007870341,
-0.017135426,
-0.013416109,
0.034483384,
-0.015169501,
0.035785146,
-0.012492921,
0.030790634,
0.012492921,
-0.007996532,
-0.026447004,
-0.014093556,
0.0051837987,
0.019167768,
0.012393297,
0.025517173,
0.014478771,
-0.028319946,
-0.0121874055,
-0.027416682,
-0.01192174,
-0.03150793,
0.005117382,
-0.014345938,
0.0030070017,
-0.007923475,
0.011423618,
-0.0022598174,
0.040434293,
-0.021970538,
0.021479057,
0.0052037234,
-0.01285157,
-0.011802191,
0.0018015443,
-0.008355181,
0.034297418,
-0.03004677,
-0.0054527847,
-0.024481079,
-0.037883904,
0.018357487,
0.0066947713,
-0.018344205,
0.038255837,
-0.02497256,
-0.017414374,
-0.019592833,
0.0003640448,
-0.0014154991,
-0.0033905562,
-0.0072460272,
0.03759167,
-0.02250187,
0.0025454077,
-0.00072352344,
0.010135139,
0.008780246,
0.0069338703,
0.0010892287,
-0.033420723,
-0.017401092,
0.022289338,
0.011968232,
0.044259876,
0.003388896,
-0.040407725,
-0.006674846,
0.0054361806,
-0.024640476,
-0.019752232,
0.01902165,
-0.06418479,
-0.015023385,
-0.0031431552,
0.03328789,
0.02453421,
0.008488013,
0.016139181,
0.00034536517,
0.031082867,
-0.008355181,
0.014744436,
0.009630376,
-0.0138943065,
-0.016683795,
-0.0005209535,
-0.0035034642,
-0.0047853,
0.020748477,
-0.004526276,
-0.023006635,
-0.014385788,
-0.0035300306,
-0.0007239386,
0.010267972,
-0.01880912,
0.03615708,
-0.01880912,
0.013376259,
-0.004330348,
-0.0030136432,
0.015860232,
-0.0027911484,
-0.0017401092,
0.0015840307,
-0.026911918,
-0.036077376,
-0.004127778,
0.0007882794,
0.011576375,
-0.007916832,
0.008295406,
-0.0156477,
-0.01277187,
0.0058379997,
0.00086424313,
-0.00086258276,
0.0008023929,
0.0027596005,
-0.005575655,
0.01475772,
-0.0053166314,
-0.03575858,
0.001982529,
0.01698931,
-0.001476104,
-0.011775624,
-0.012811719,
0.0012444769,
-0.013529017,
-0.022116655,
-0.016457979,
0.0075515425,
0.023750497,
0.005250215,
0.00884002,
-0.01625873,
-0.035041284,
-0.030684369,
-0.023059767,
0.005064249,
0.0038753957,
0.016869761,
0.029621705,
-0.015435167,
0.0060604946,
0.0013067423,
0.017042443,
-0.0046889964,
-0.01374819,
0.007186252,
0.0012710434,
0.033420723,
0.0087736035,
-0.02967484,
0.00973,
0.0032128925,
0.0014520282,
-0.023378566,
0.009623733,
0.0038056585,
0.028240245,
0.0025703139,
0.019008368,
0.025198374,
0.034881882,
0.009178744,
-0.036263343,
-0.015010102,
0.0034204435,
0.010991911,
-0.022276053,
0.022183072,
-0.028001146,
0.022023672,
0.006130232,
-0.021997105,
-0.021983823,
0.01390759,
-0.00023307999,
0.037405707,
0.011184518,
0.027469816,
0.008687262,
0.0072061773,
-0.013276635,
0.0136684915,
-0.0018513566,
-0.03219866,
0.0025321245,
0.020270279,
0.018755985,
-0.023179317,
0.021837706,
0.0012901382,
-0.034935016,
0.01946,
0.013681774,
-0.013934157,
-0.026526703,
0.016763495,
0.022129938,
0.011330634,
-0.0035433138,
-0.008175856,
-0.017042443,
-0.007066703,
0.00851458,
-0.0025968805,
0.014027139,
0.00012276653,
-0.014000573,
-0.0144920545,
-0.00031194944,
-0.024786593,
0.003393877,
-0.018277789,
0.0038853583,
0.19329824,
0.004576089,
0.0011830418,
0.03634304,
-0.010128498,
-0.013303201,
0.010739529,
-0.0029754539,
0.009218594,
0.0062697064,
0.017347958,
-0.006867454,
-0.009975741,
-0.005871208,
0.023896614,
-0.0016736928,
0.00025881635,
-0.0066383174,
0.0019692457,
0.011536526,
0.028957542,
-0.025995372,
0.013289918,
-0.011483393,
0.017401092,
0.0037890545,
-0.04513657,
-0.0121608395,
-0.0034669351,
0.017401092,
-0.02728385,
0.012652321,
0.021372791,
0.0005375576,
-0.0028642064,
0.004479785,
-0.013323126,
-0.012539413,
-0.009397917,
-0.015900081,
-0.0053465185,
-0.010633263,
-0.025131958,
-0.0071331193,
-0.022661269,
0.021957256,
-0.0105668465,
-0.0193803,
-0.015700832,
0.014903836,
-0.036927506,
0.010726245,
-0.006276348,
0.021439208,
0.0009937551,
0.0052767815,
0.03668841,
-0.013801324,
0.015196068,
0.030099904,
-0.020256996,
0.0022797422,
-0.044658374,
-0.020256996,
-0.02469361,
0.010513713,
-0.008654054,
0.0070002866,
0.029010676,
-0.03235806,
0.013170368,
-0.0101683475,
-0.005781546,
0.02696505,
-0.016484546,
-0.005834679,
0.032650292,
0.03222523,
0.032384627,
0.008209065,
0.012293672,
-0.006807679,
-0.012898061,
0.004333669,
0.003065116,
-0.009291652,
0.01987178,
0.02084146,
0.0037525254,
0.013329768,
-0.0055690133,
-0.005296706,
-0.016205598,
-0.0015317277,
-0.017972272,
-0.0026981654,
-0.032331493,
-0.0010634923,
0.003138174,
-0.016683795,
-0.022687836,
0.05172508,
0.021930689,
-0.01544845,
0.0055822968,
0.0038388667,
0.033739522,
0.012944553,
-0.008521222,
-0.020775044,
0.02404273,
-0.017587058,
0.031162566,
-0.003256063,
0.010008949,
0.014956969,
-0.0047255256,
-0.040646825,
0.008600921,
-0.001962604,
0.012585904,
-0.016550962,
-0.014013857,
0.0123600885,
-0.012267105,
0.0026450322,
-0.020256996,
0.02522494,
-0.011290785,
-0.010155065,
0.0024291791,
0.017653475,
0.019114634,
0.020775044,
0.01726826,
-0.013588792,
0.03559918,
-0.0057383752,
-0.016245447,
-0.005087495,
0.012061215,
-0.022674553,
0.005104099,
0.0098097,
-0.015103085,
-0.013854457,
0.014239672,
0.017161993,
-0.014744436,
-0.005665317,
-0.016139181,
0.004111174,
0.0018646399,
-0.00026691082,
-0.024401378,
-0.011848683,
-0.017613623,
-0.041868888,
0.0017782986,
0.022249488,
-0.05023735,
0.016856477,
0.0050675697,
-0.005080853,
-0.027549515,
0.00029576046,
-0.16683795,
0.0014238012,
0.0071131946,
-0.017507358,
0.028851276,
0.035997678,
0.031534497,
0.0057184505,
0.006913945,
0.018795835,
0.007226102,
0.02712445,
-0.031481363,
-0.028107412,
-0.018516887,
-0.009318219,
-0.004566126,
-0.017095577,
0.03267686,
-0.004788621,
0.024720177,
-0.014106839,
0.01706901,
-0.028027713,
0.0053797266,
0.03174703,
-0.010274614,
-0.0031796843,
0.030498402,
-0.012220614,
-0.012552696,
0.009125611,
0.025317924,
-0.044259876,
0.036316477,
-0.00011010591,
0.0068209623,
0.005280102,
-0.006017324,
0.003109947,
0.019207617,
0.003725959,
-0.009225235,
-0.023936464,
0.008647413,
0.023936464,
0.00697372,
0.01536875,
0.008016457,
-0.00490485,
0.0231129,
-0.021970538,
0.01918105,
0.006419143,
0.023444982,
-0.016869761,
-0.0067113754,
0.02108056,
0.0016263712,
0.01698931,
-0.007026853,
-0.0034470102,
0.0383621,
0.0015873516,
-0.007524976,
-0.05276117,
-0.008727113,
-0.0050011533,
-0.03621021,
0.024507644,
-0.023989597,
0.017401092,
0.001349913,
-0.023365283,
0.016869761,
0.026566552,
-0.014226389,
0.0036362968,
-0.020283563,
-0.008142648,
-0.018211372,
0.045907002,
-0.016019631,
0.0021884197,
-0.0043203854,
0.013734908,
-0.017852724,
0.012028007,
0.0021552115,
0.0063228393,
0.0028210357,
-0.021983823,
0.0021834385,
-0.01698931,
-0.0034602934,
0.02384348,
0.017055726,
-0.0050742114,
-0.0054461434,
-0.013515733,
0.0069471532,
-0.014000573,
-0.009789774,
0.009025986,
0.026367303,
0.013761474,
0.008833379,
0.016311863,
0.043090947,
-0.0012270426,
-0.0035632388,
-0.0015815401,
-0.011416975,
0.0122737475,
0.008454805,
0.039504465,
-0.013641925,
0.008408314,
-0.0060837404,
-0.011828758,
0.07959339,
0.005907737,
-0.029595139,
0.0028127336,
0.005233611,
-0.0138943065,
-0.1235876,
-0.017175276,
-0.00030800595,
0.043276913,
-0.005456106,
0.030020203,
-0.015328901,
0.03581171,
-0.003981662,
0.024999125,
-0.02611492,
-0.015554717,
-0.00895957,
-0.008302048,
-0.014452204,
-0.0029140187,
-0.008933003,
-0.012067856,
-0.025742989,
0.024879577,
0.001196325,
0.008766962,
-0.0118752485,
-0.016032914,
0.012147556,
-0.01710886,
-0.021133693,
0.009524109,
0.0077375085,
0.009311576,
0.0043369895,
-0.003349046,
0.007617959,
0.008494655,
-0.029940505,
0.014465488,
-0.02481316,
-0.022036955,
0.039052833,
-0.012346805,
-0.01163615,
-0.0041543446,
0.01775974,
-0.0070534195,
0.0053664437,
-0.016404847,
0.0033357628,
0.004911491,
-0.032703426,
0.008215706,
-0.014996819,
0.008414956,
-0.033128493,
-0.0073257266,
0.009789774,
-0.007797283,
0.014970252,
0.028266812,
-0.0040314742,
0.0012909684,
-0.004532918,
0.001325837,
-0.023006635,
-0.005080853,
0.0072393855,
-0.009417843,
-0.0037691295,
-0.016245447,
0.018370772,
-0.020562511,
-0.010208198,
-0.0023528002,
-0.022116655,
0.0023079691,
-0.020004613,
-0.008375105,
-0.022435453,
-0.017321393,
0.015023385,
-0.020256996,
-0.00049521716,
-0.01690961,
0.01710886,
-0.018676287,
0.010367597,
-0.007724225,
0.009192027,
0.0038289044,
0.01009529,
-0.0022415528,
-0.0036927508,
0.043861378,
-0.026938483,
-0.025038976,
-0.0070799864,
0.022395603,
-0.015740681,
0.0032710067,
0.02157204,
-0.016776778,
-0.038229268,
-0.024959275,
-0.053797267,
0.009238519,
0.011589658,
-0.024135713,
0.0015059914,
0.00038708298,
0.014956969,
-0.026287604,
0.0031182491,
-0.01451862,
-0.04824486,
0.0024059333,
-0.02323245,
-0.009955815,
-0.026101638,
-0.030153036,
0.02161189,
-0.005525843,
-0.0005578976,
0.004888246,
-0.0009754906,
-0.011569734,
0.01625873,
0.023511399,
0.011058328,
0.0065420135,
0.0030700972,
0.015421883,
-0.007943399,
-0.007505051,
0.008673979,
-0.033394158,
-0.019420149,
-0.000163239,
0.009371351,
0.0077507915,
-0.011855324,
0.033181623,
0.021213392,
0.032783125,
-0.04322378,
-0.053159673,
0.01200144,
0.010367597,
-0.029010676,
-0.00086424313,
-0.028532477,
0.006658242,
0.0009829624,
-0.02627432,
0.03634304,
0.008182498,
-0.010427372,
-0.015421883,
-0.0075913924,
0.00458273,
-0.0034005188,
-0.0018397338,
-0.004317065,
-0.013223502,
0.019818649,
0.0072460272,
-0.0026848821,
0.0018712815,
0.023577815,
0.0035665596,
-0.026991617,
-0.022103371,
-0.004718884,
-0.0035067848,
-0.01593993,
0.032251794,
0.007265952,
-0.01050043,
-0.007923475,
0.0056819213,
-0.01633843,
0.0023345358,
-0.0031979487,
-0.014863986,
0.0025371057,
-0.0072792354,
-0.02728385,
0.017826157,
0.03838867,
0.010546921,
0.0016936177,
0.03676811,
-0.0060206447,
-0.0052269693,
0.016869761,
0.011503317,
-0.000279779,
-0.008926362,
0.0035632388,
0.028213678,
-0.011888532,
0.018397337,
0.011662716,
-0.014133406,
0.0008592619,
-0.00007819491,
0.013734908,
-0.013734908,
-0.008488013,
0.039398197,
-0.034403685,
-0.03666184,
-0.008693905,
0.0024325,
0.024613911,
-0.0003737997,
0.01293127,
0.015660983,
0.010360955,
0.011755699,
-0.00523029,
-0.011483393,
-0.0010170009,
0.02161189,
0.008986136,
0.025131958,
-0.00060480414,
0.0036196928,
0.021957256,
0.007153044,
0.022036955,
-0.013369617,
0.0008592619,
0.004815188,
0.030710934,
0.010872361,
-0.005177157,
-0.00547271,
0.0099690985,
0.00616344,
0.006425785,
0.018835686,
-0.016630663,
0.08511923,
0.025490606,
-0.012818362,
-0.0075847507,
-0.036741544,
0.011483393,
0.013389543,
0.008793529,
-0.020801611,
-0.048058894,
0.021784574,
-0.004712242,
0.032384627,
-0.025171809,
-0.012732021,
0.029488873,
-0.010792661,
0.01042073,
-0.027443249,
-0.015727399,
0.015807098,
-0.017215125,
0.005100778,
-0.002952208,
-0.004512993,
0.005592259,
0.0060638157,
-0.013323126,
-0.009889399,
-0.019074785,
0.01536875,
-0.010872361,
-0.037697937,
-0.0026981654,
0.015169501,
0.004566126,
-0.009172102,
-0.000008386365,
0.03536008,
-0.0026865427,
0.010879003,
-0.004848396,
-0.0027097883,
-0.020655494,
-0.0032510818,
-0.012725378,
0.016697079,
0.009344785,
0.006425785
] |
Trypanosoma brucei, the causative agent of African sleeping sickness, is transmitted to its mammalian host by the tsetse. In the fly, the parasite's surface is covered with invariant procyclin, while in the mammal it resides extracellularly in its bloodstream form (BF) and is densely covered with highly immunogenic Variant Surface Glycoprotein (VSG). In the BF, the parasite varies this highly immunogenic surface VSG using a repertoire of ~2500 distinct VSG genes. Recent reports in mammalian systems point to a role for histone acetyl-lysine recognizing bromodomain | [
-0.015295288,
0.0018783687,
0.0015068877,
-0.02844387,
0.0064535383,
0.030536909,
-0.018099423,
-0.0076543526,
-0.024754217,
-0.0039781164,
0.012893659,
0.0049709687,
0.03166393,
-0.014034098,
0.003355907,
0.009962062,
0.027907193,
-0.0006993569,
-0.0033106247,
-0.022325754,
-0.02237942,
0.00042829322,
0.005457332,
-0.0003509363,
0.015147702,
0.019347198,
-0.0057491497,
-0.024150455,
-0.024861552,
0.018099423,
-0.007828772,
-0.024338292,
-0.026297161,
0.009230841,
0.00019800437,
-0.024459044,
0.009968771,
-0.00052577554,
0.013356543,
0.00607451,
0.00084694306,
0.035850007,
-0.016771149,
0.010881121,
-0.009257674,
-0.000019129591,
0.00056015636,
0.0024301396,
-0.014959865,
0.0043001226,
0.009760809,
0.005105138,
-0.018971523,
0.0012435807,
-0.01702607,
-0.016972402,
0.0061784913,
0.0020158922,
0.03614518,
-0.036816027,
-0.010331028,
-0.012316732,
-0.030080734,
-0.005470749,
0.0013249208,
0.0283902,
-0.0023144186,
0.01032432,
-0.008989336,
0.0027035093,
0.05208448,
0.02408337,
0.00042431007,
-0.0073055127,
0.024190705,
-0.02134632,
-0.0319591,
0.008392283,
0.0010272329,
0.01049874,
0.033032455,
-0.003914386,
-0.028470702,
0.024512712,
0.01716024,
0.009378427,
-0.009250966,
0.023278356,
0.009653473,
-0.0032334775,
0.006436767,
0.01750908,
-0.011766639,
0.020138796,
-0.013564506,
-0.0050279903,
0.008076985,
0.02621666,
-0.0043739155,
-0.01873002,
-0.0032569573,
0.0000490032,
-0.016730899,
-0.0176835,
-0.0140877655,
0.018676352,
-0.019226445,
-0.003488399,
-0.00015639096,
-0.021104814,
-0.02221842,
0.035608504,
0.0032888222,
-0.06279118,
0.024727382,
-0.002336221,
0.025505563,
-0.013537671,
0.003750029,
-0.004058618,
0.019696038,
0.019709455,
0.021359736,
-0.0027538226,
0.016529644,
0.0060778647,
-0.015738046,
-0.017455412,
0.00050774653,
-0.016274722,
0.012444193,
0.014101182,
0.0004062811,
-0.011941059,
-0.00350517,
0.0005287105,
-0.034293644,
-0.0037567373,
-0.0040485556,
-0.009740683,
0.01092808,
0.028712207,
-0.021748826,
0.0026213306,
-0.0006968412,
0.023238104,
0.006466955,
0.015536793,
0.004763006,
0.007191469,
0.027383933,
-0.012028269,
0.029624557,
-0.0010071076,
0.0036091513,
0.024163872,
-0.017039487,
0.034937657,
-0.024579797,
-0.003329073,
-0.0032133523,
0.010190151,
0.025438478,
0.013604756,
0.014745194,
0.019306947,
0.0066615003,
0.0067654816,
-0.0030523492,
-0.011786764,
-0.022620926,
0.020943811,
-0.026847256,
0.033998474,
-0.020031461,
0.013094913,
0.017562747,
-0.0010632909,
-0.012068519,
-0.014611025,
-0.009110088,
0.02012538,
0.031771265,
0.005195702,
-0.0087813735,
0.011437924,
0.014839113,
-0.040062923,
0.036574524,
-0.021118231,
0.00042577754,
0.0037735086,
0.010129774,
-0.029517222,
-0.6431534,
-0.03426681,
-0.001167272,
-0.008204446,
0.0013148581,
-0.00088048534,
0.016865067,
-0.018609267,
-0.045563858,
0.031234588,
-0.008264822,
0.0022875848,
0.016006384,
-0.03845289,
0.00095847115,
-0.018783687,
-0.014879364,
-0.0016133846,
0.027585186,
0.0004138281,
-0.010874413,
-0.008486201,
-0.01093479,
0.033300795,
0.004233038,
0.006433413,
0.027504684,
-0.036547687,
0.0055713756,
0.02565315,
-0.02517014,
0.049723104,
-0.014315853,
0.0044410005,
0.04642254,
-0.02121215,
-0.0008360418,
0.018542182,
0.037084363,
0.026887506,
-0.015402623,
-0.00568542,
0.02142682,
0.009640057,
-0.017039487,
0.021145064,
0.003152976,
-0.0010674837,
-0.0017827732,
-0.014382938,
0.0038841981,
-0.0012502891,
-0.015603878,
0.019159362,
0.0006943256,
-0.001443996,
0.00078908255,
-0.027209513,
0.020621805,
-0.008942377,
-0.013732217,
0.016999237,
0.021534156,
-0.024593214,
-0.0044242293,
-0.002976879,
-0.009324759,
0.0075939763,
0.008593537,
-0.012014851,
0.023989452,
0.02739735,
-0.035420667,
0.025975157,
-0.001532883,
0.030671077,
0.00063101447,
0.0012435807,
-0.019722871,
-0.0010222015,
-0.009485762,
-0.0050883666,
-0.029383054,
0.0022137917,
0.016180804,
-0.020313216,
-0.024566378,
0.0012360337,
-0.004585232,
-0.0012746074,
0.021332901,
0.034132645,
-0.015134285,
-0.021748826,
-0.027826691,
0.027249763,
0.028846378,
-0.002042726,
-0.0053097457,
-0.017482245,
-0.008258114,
-0.011719679,
0.0016385412,
-0.023721114,
0.015791714,
-0.01084087,
-0.047066554,
0.0015605554,
0.039043237,
-0.02103773,
-0.014959865,
-0.011270212,
0.0079294,
-0.01489278,
0.000039385995,
-0.018984942,
0.027558353,
0.0149866985,
0.0054774573,
-0.053801846,
-0.0053030374,
0.026323996,
-0.0074195564,
-0.008747831,
0.017737167,
0.016489394,
0.008130653,
-0.036547687,
-0.01859585,
-0.006071156,
-0.004578524,
-0.0016771149,
0.02887321,
-0.018689768,
0.009371718,
0.0043806243,
0.03397164,
0.015295288,
0.0055814385,
-0.011598927,
-0.0095058875,
-0.012786324,
0.0006054385,
0.01995096,
-0.010894539,
-0.017522497,
-0.009968771,
-0.007238428,
0.010518865,
-0.0035387124,
0.02547873,
-0.0131888315,
0.000036398636,
-0.001927005,
0.030241735,
-0.016556479,
-0.005732379,
-0.011753221,
-0.002948368,
0.015791714,
0.011840431,
0.01563071,
-0.00919059,
0.009854727,
-0.013953596,
-0.021010896,
0.019186195,
0.0105792405,
0.0069231302,
-0.031985935,
0.026055658,
-0.014315853,
-0.011350714,
0.033327628,
0.026578918,
0.019172778,
0.010270651,
-0.012403942,
-0.029544057,
-0.005343288,
-0.0064602466,
0.0075537255,
0.0041659535,
-0.009204007,
0.042021792,
0.00590009,
0.030590575,
0.0026297162,
0.017348077,
0.029892895,
-0.009284508,
0.021923246,
-0.03287145,
-0.00642335,
0.0045718155,
-0.024391958,
0.027290015,
0.027155844,
-0.006641375,
0.009532721,
0.007808647,
-0.0026162993,
-0.0058799647,
-0.027477851,
0.023238104,
-0.036789194,
0.0005085851,
-0.010471906,
0.0054506236,
0.013094913,
0.009479053,
0.003998242,
0.0036661732,
0.0014901166,
0.020702306,
-0.012249648,
0.012866826,
0.0011328912,
-0.0024821302,
-0.01580513,
-0.022540424,
0.005514354,
0.015925882,
-0.0069365473,
0.0025341206,
0.024834719,
-0.00770802,
0.026592335,
0.012464318,
-0.013886511,
-0.015952718,
0.0017408453,
-0.002552569,
0.017844502,
0.018126259,
-0.01597955,
0.0061851996,
0.0037299036,
0.023586944,
-0.011082375,
0.0062824725,
0.009814477,
0.0076811863,
-0.0009970448,
0.012296607,
0.025747068,
0.007137801,
0.0014154849,
-0.0119611835,
0.0027035093,
-0.019508202,
0.0026079137,
-0.02256726,
0.0095058875,
-0.0029802332,
0.004186079,
-0.008325199,
0.014865947,
0.037379537,
0.01842143,
0.0057122535,
-0.010860996,
-0.0039445744,
-0.020608388,
0.01615397,
0.016771149,
-0.02321127,
-0.015778298,
0.0027370516,
0.01646256,
-0.025384812,
-0.008063569,
0.00367959,
-0.031556595,
0.021238983,
-0.0023664092,
-0.0065340395,
-0.004816674,
0.0016838234,
0.006624604,
-0.033408128,
-0.017267575,
-0.00945222,
0.022661177,
-0.010176733,
-0.020313216,
-0.008036735,
0.0121154785,
0.010706701,
0.032898284,
0.029973397,
0.011404381,
-0.0127729075,
-0.008432534,
0.0063596196,
-0.00659777,
0.028551204,
0.0038439473,
0.011672719,
-0.012464318,
-0.009693724,
0.013094913,
-0.015147702,
-0.005853131,
0.036520854,
0.0026632585,
-0.02068889,
0.0030858915,
-0.00042535827,
0.0010859319,
-0.0002769336,
-0.020715723,
-0.018984942,
-0.040009253,
-0.0029617848,
0.032012768,
-0.019347198,
0.00020209234,
0.010424946,
-0.018260427,
-0.04481251,
-0.032039605,
-0.011290338,
-0.024982303,
0.03061741,
0.037647877,
-0.025317727,
0.020608388,
0.01589905,
0.012645447,
-0.022446506,
-0.023117352,
0.022607509,
0.0060912813,
-0.01964237,
-0.006976798,
0.008828333,
-0.0002693866,
0.026069075,
0.014946448,
-0.014637859,
-0.018273843,
-0.00062766025,
0.025747068,
0.015147702,
-0.013148581,
0.006701751,
0.034239978,
0.019964376,
-0.003921095,
-0.011894099,
0.010156608,
-0.007278679,
-0.03222744,
-0.015281871,
-0.026364246,
0.013537671,
0.028685374,
0.0079294,
-0.018475099,
-0.016704064,
0.016449142,
-0.0010171701,
-0.015912466,
0.019521618,
0.024459044,
0.0045651067,
0.021842744,
0.015483125,
-0.007104259,
-0.0022607509,
-0.02152074,
-0.010055981,
-0.0149866985,
0.028980546,
0.0013710414,
-0.01568438,
-0.007949525,
0.009982188,
-0.00084694306,
-0.0021399986,
0.005769275,
-0.0036527563,
-0.010968331,
0.009089963,
-0.01572463,
0.001013816,
-0.006450184,
-0.0061080526,
-0.0010758692,
0.007674478,
-0.018233594,
-0.044007495,
-0.015134285,
0.020192463,
-0.055116706,
-0.017294409,
-0.02186958,
0.017455412,
0.012310023,
0.0024838073,
-0.025371395,
0.005256078,
0.012806449,
-0.034213144,
-0.0082983645,
0.0141951,
-0.028819542,
0.006171783,
0.0019420991,
0.031073585,
-0.03118092,
-0.0013844584,
0.004934072,
0.00997548,
0.011652594,
-0.0030255152,
-0.00067084597,
0.009177173,
0.008090402,
0.01380601,
0.028470702,
-0.009465637,
-0.011216545,
0.022473339,
-0.019588701,
-0.0004670765,
-0.011431215,
0.024861552,
-0.0024485877,
0.002671644,
-0.01398043,
-0.03222744,
-0.011156169,
0.008908834,
-0.024485879,
-0.0031999352,
0.000074002695,
0.033300795,
-0.0049407803,
-0.0066615003,
0.024633463,
-0.012699114,
-0.013423628,
0.0040921606,
-0.010532281,
0.021091398,
0.016717482,
-0.011820306,
0.023707697,
0.019266697,
-0.0025408291,
-0.0052627865,
0.00066287967,
0.0025777256,
0.0336228,
0.012041685,
-0.018327512,
-0.019763121,
-0.017925004,
-0.0067520645,
-0.008734414,
0.005604918,
-0.0006976798,
-0.011028708,
0.0060174884,
0.017294409,
-0.018059174,
0.0046757963,
-0.03440098,
-0.0052191815,
0.01572463,
-0.01607347,
-0.004974323,
-0.010190151,
-0.015134285,
-0.0101633165,
-0.017012654,
-0.021802494,
-0.037835713,
-0.018998358,
0.005893382,
0.03496449,
0.031690765,
0.022312338,
0.01977654,
0.02303685,
0.030456407,
0.0061415946,
0.0052024103,
0.0009442157,
0.005024636,
-0.021077981,
0.021158481,
0.016918736,
-0.00866733,
0.005688774,
-0.013269333,
0.037003864,
0.019722871,
-0.0072853873,
-0.02342594,
-0.0037835713,
-0.027987694,
-0.015845383,
0.019347198,
-0.0001044004,
0.010505448,
-0.04467834,
-0.0057021906,
0.03265678,
-0.010478614,
-0.0029232113,
-0.0090228785,
0.025317727,
-0.007909274,
0.0048636333,
-0.010545699,
-0.0008720998,
-0.015187953,
0.0048401537,
0.010807329,
-0.004420875,
0.023171019,
-0.009318051,
-0.0057156077,
0.020098545,
0.013396794,
-0.00006582676,
0.011840431,
-0.008647204,
-0.011585509,
-0.007191469,
0.0042967685,
-0.04094844,
-0.02600199,
-0.020326633,
-0.04116311,
-0.0019722872,
0.022607509,
-0.023050267,
0.020849893,
0.012786324,
-0.03206644,
0.016516227,
-0.007714729,
0.03990192,
-0.0067654816,
0.022191584,
0.021802494,
-0.0011060573,
-0.025814153,
-0.00034548566,
0.005957112,
-0.004404104,
0.016167387,
0.014839113,
-0.018314095,
-0.02142682,
0.0099218115,
0.017562747,
-0.026122741,
-0.028953712,
0.0062690554,
-0.026256911,
-0.013007703,
-0.009123505,
-0.019924125,
-0.008352032,
0.035393834,
-0.015120868,
0.001809607,
0.009532721,
-0.022647759,
-0.023157602,
0.009868144,
0.0052661407,
0.025264058,
-0.008888709,
-0.003968054,
-0.008975919,
-0.012041685,
-0.02203058,
0.00677219,
-0.0034682737,
0.037728377,
-0.0014507044,
-0.018998358,
0.0021936663,
0.01607347,
-0.0033005623,
0.003020484,
0.0017257512,
0.039579913,
-0.012028269,
0.002859481,
0.009740683,
0.01380601,
0.00057692756,
0.006520623,
0.0063227233,
0.009606514,
0.0035252955,
-0.015992967,
0.01603322,
0.025371395,
-0.0019001712,
-0.0051152003,
-0.018891022,
-0.012719239,
-0.020004626,
-0.025961738,
-0.00819103,
-0.041136276,
0.00559821,
-0.010210276,
0.0113037545,
0.014490273,
0.014637859,
0.0029533994,
-0.007540309,
0.036735523,
-0.010639617,
-0.0057390872,
0.026069075,
0.009136922,
-0.030697912,
-0.0044879597,
-0.015255038,
-0.022795346,
0.010203567,
-0.0051789307,
-0.017280992,
-0.028712207,
0.008097111,
0.02704851,
-0.0063696825,
-0.043873325,
0.025760485,
0.011914224,
0.026900923,
-0.018340928,
0.0022506882,
0.024324875,
-0.01454394,
-0.012316732,
0.019159362,
-0.018542182,
-0.018086007,
0.009519304,
-0.018153092,
0.007862315,
-0.015483125,
-0.0077683963,
0.01088783,
-0.0031110481,
0.013416919,
-0.018823938,
0.0028695436,
-0.016610146,
-0.010921372,
0.011900808,
-0.009163756,
-0.027585186,
-0.028068196,
-0.013832844,
-0.03279095,
-0.0060577393,
-0.017629832,
0.019508202,
0.008814916,
-0.049830437,
-0.04454417,
-0.008459368,
-0.02600199,
0.040062923,
-0.0021718638,
-0.0054070186,
-0.011317171,
0.0012637061,
-0.048757084,
0.017455412,
0.013383377,
0.021936662,
0.020018043,
0.0283097,
0.011136043,
0.000522002,
0.009633348,
0.024673715,
0.009767517,
-0.013577922,
0.028551204,
0.021332901,
0.012732657,
0.02237942,
-0.030805247,
0.012658863,
0.034105808,
0.015295288,
-0.011397673,
0.017455412,
-0.014181684,
0.013161998,
0.009559555,
0.008794791,
-0.025894655,
0.0050715953,
0.020702306,
-0.0069097136,
-0.005474103,
-0.0037701544,
-0.010176733,
-0.019065442,
-0.01524162,
0.014637859,
0.0010976717,
0.022285502,
-0.0158588,
-0.012524694,
0.0050279903,
-0.030107567,
0.011162877,
0.010210276,
0.013068079,
0.019857042,
-0.01041153,
-0.011894099,
0.00028049748,
0.012611904,
-0.03531333,
-0.006842629,
-0.011780055,
-0.00057273475,
0.0028259386,
0.012524694,
0.005688774,
-0.01698582,
0.015268454,
-0.01206181,
-0.033595964,
-0.036172014,
0.013953596,
0.007754979,
-0.014181684,
-0.011639178,
-0.006916422,
-0.0030322238,
-0.007573851,
0.0017760647,
0.0036494022,
0.01080062,
0.014959865,
-0.0038003423,
-0.011022,
-0.018153092,
-0.019588701,
0.0014163236,
-0.013088205,
-0.0074061393,
0.17356128,
-0.011793472,
0.006607833,
0.02185616,
-0.015255038,
-0.013691966,
0.015885632,
-0.011853849,
0.009720558,
0.011297046,
0.018850772,
-0.007439682,
-0.013765759,
0.0024838073,
-0.006916422,
-0.0014104537,
-0.030402739,
0.011880682,
-0.013665132,
-0.024539545,
0.00953943,
-0.0070841336,
-0.0018884314,
-0.0049575516,
0.028417036,
0.005467395,
-0.024968887,
-0.0061851996,
-0.0025039327,
0.0027169262,
-0.0051353257,
0.018059174,
-0.011317171,
0.009834602,
-0.0052896203,
0.005806172,
-0.0022087602,
-0.009613222,
0.008466076,
0.026726503,
0.0010582595,
0.024391958,
-0.013403502,
-0.0072317193,
-0.018300679,
0.009183881,
0.0051722224,
-0.0045315647,
-0.012450901,
0.020554721,
-0.038077217,
0.006258993,
-0.011827014,
0.01667723,
0.013738926,
-0.004977677,
0.025639733,
0.013685258,
-0.008720998,
0.019883875,
-0.012625321,
0.018233594,
-0.031100418,
0.047308058,
0.015335538,
0.04628837,
-0.018367762,
0.015966134,
0.033112958,
-0.02150732,
-0.028658539,
-0.009613222,
-0.010894539,
0.0007027112,
0.0046791504,
-0.009546138,
0.02499572,
0.0051453887,
0.025277477,
0.012397233,
-0.0239492,
-0.009968771,
-0.01214902,
0.0033911264,
0.0056250435,
-0.044222165,
0.018636102,
-0.000040381783,
-0.006128178,
-0.005108492,
0.014839113,
-0.0018515348,
-0.0010414884,
-0.012444193,
0.013208957,
-0.012779616,
0.013094913,
0.013497421,
0.0048367996,
-0.023667445,
-0.030912582,
0.043148812,
0.005544542,
0.005380185,
-0.008989336,
0.016086886,
-0.016650397,
0.00066916883,
0.0023865346,
-0.012779616,
-0.0070237573,
-0.013383377,
0.0072518447,
-0.025062805,
0.0036426936,
0.018917857,
0.0126186125,
-0.012276481,
0.028980546,
-0.008949085,
0.009492471,
-0.033461798,
0.014490273,
0.02704851,
-0.011726388,
-0.016891902,
-0.011068959,
0.0127729075,
-0.010270651,
-0.039526243,
0.001642734,
-0.0029584307,
-0.01572463,
-0.009257674,
0.0043403734,
0.005239307,
-0.0012653832,
-0.0026012051,
-0.01981679,
0.009519304,
0.0016762763,
-0.007815355,
0.007547017,
0.003137882,
-0.015053784,
-0.0283902,
0.01824701,
0.0035621922,
-0.015885632,
0.010807329,
-0.029463556,
-0.024485879,
0.008244697,
-0.005292975,
0.03131509,
-0.031288255,
-0.0019454533,
-0.035850007,
0.009110088,
0.0028712207,
-0.041968122,
-0.001839795,
0.009606514,
-0.027665688,
0.012316732,
0.0041525364,
-0.17034121,
-0.0016603437,
0.0048971754,
-0.017696917,
0.023962619,
0.028014528,
0.02852437,
0.0027102176,
-0.01720049,
0.016006384,
0.023533277,
0.0028343243,
-0.044275835,
-0.025988573,
0.0028360013,
-0.01241065,
-0.022956349,
0.034427814,
0.02233917,
-0.0023127415,
0.021359736,
-0.031127254,
0.0007748271,
-0.020957228,
-0.0022255315,
0.012457609,
0.008962502,
-0.010639617,
-0.002158447,
-0.016475977,
-0.026364246,
0.0018515348,
0.013584631,
-0.024190705,
0.019400865,
-0.013383377,
-0.023654029,
0.0051152003,
-0.010143191,
0.01572463,
0.010337736,
0.012732657,
-0.011001874,
0.0043839784,
-0.007801939,
0.010304194,
-0.005279558,
0.0038070509,
0.036118347,
0.0010163316,
0.019615537,
0.012263064,
0.008284948,
0.023144186,
0.0185556,
-0.023506442,
0.0135175465,
0.0017727105,
0.019521618,
-0.0014834082,
-0.02635083,
-0.01737491,
0.029409887,
-0.0021081334,
0.0065306854,
-0.011813598,
-0.015120868,
0.008727706,
-0.0095058875,
0.00624893,
0.000019968149,
0.0026649355,
-0.004846862,
-0.03523283,
0.0002945433,
0.026578918,
-0.012491152,
0.010284069,
-0.003488399,
-0.0074061393,
-0.033461798,
0.018045757,
-0.015791714,
-0.00997548,
-0.015845383,
-0.0009635025,
0.0095058875,
0.0037600917,
-0.00849291,
0.0047797775,
0.006654792,
-0.0176835,
0.01568438,
-0.030053899,
0.030000232,
0.020111961,
-0.0016754378,
-0.020420551,
0.01580513,
0.035205998,
0.0212524,
-0.011894099,
-0.04478568,
0.014839113,
0.01559046,
-0.0076946034,
-0.0012729302,
0.0023999515,
0.051842976,
-0.009371718,
-0.010082815,
-0.00045575597,
0.013510838,
0.014825696,
0.010606075,
0.036386684,
0.017079739,
-0.01080062,
0.008882001,
-0.019910708,
0.071270674,
0.008204446,
0.0042397464,
0.025747068,
-0.020420551,
-0.009559555,
-0.123006314,
0.0053030374,
-0.013463879,
0.011142751,
-0.0035387124,
0.0058330055,
0.005688774,
0.0012293252,
-0.0037600917,
-0.0008611985,
-0.019964376,
-0.01789817,
0.013296167,
-0.01580513,
0.015509958,
0.02103773,
0.011022,
0.0047194012,
-0.01080062,
0.029624557,
0.0046020034,
0.0037164867,
-0.02303685,
-0.0027471143,
0.012182563,
0.0046321913,
-0.027102178,
0.0026615814,
0.013349835,
0.013738926,
0.007312221,
-0.03440098,
0.01559046,
0.0015831965,
-0.031771265,
-0.0038271763,
-0.019843623,
-0.020769391,
0.032629948,
-0.01058595,
-0.024016285,
0.011048833,
0.033542298,
0.0067185224,
0.005631752,
0.009546138,
-0.019937541,
0.020849893,
0.024526129,
-0.029812396,
-0.009029587,
-0.03461565,
-0.042155962,
-0.036869694,
0.03984825,
-0.045993198,
-0.024163872,
0.036896527,
-0.02604224,
0.015442874,
-0.008499619,
0.01820676,
0.019736288,
-0.0066346666,
0.015563627,
0.0040686806,
-0.013242499,
-0.0239492,
0.029946564,
-0.024137039,
0.009599806,
0.012222813,
-0.022647759,
-0.022996599,
-0.034991324,
-0.0015110805,
-0.012390525,
-0.010445071,
-0.0056283977,
-0.028604873,
0.0008846781,
0.0009693724,
0.031905435,
-0.010471906,
0.023667445,
0.020916978,
0.008707581,
-0.0024183998,
-0.004491314,
-0.010055981,
0.005775984,
0.009425386,
-0.006738648,
-0.030214902,
-0.00075554027,
-0.0020947165,
-0.011739804,
-0.024137039,
0.0082111545,
0.020621805,
-0.032978788,
-0.016905319,
-0.060698144,
0.0044141663,
0.01118971,
-0.0016117074,
0.0040485556,
-0.0012016528,
0.013779176,
-0.009217423,
-0.010317611,
0.003750029,
0.001159725,
0.0021047792,
-0.027504684,
0.010653034,
-0.017978672,
-0.02195008,
0.038694397,
-0.0024435564,
0.006963381,
0.03335446,
-0.011793472,
-0.0050112195,
0.0013844584,
0.027558353,
-0.006799024,
0.0031731015,
0.003823822,
0.023291772,
-0.03136876,
-0.00001086194,
0.002596174,
-0.037299037,
-0.0057961093,
0.014248769,
-0.00038804248,
-0.017911587,
-0.011578801,
0.007889149,
0.027236346,
0.033810638,
-0.015295288,
-0.0044577713,
0.0060778647,
-0.0074799326,
0.005950404,
-0.0031596846,
-0.018220177,
0.018179925,
0.00073038356,
-0.003062412,
0.013088205,
0.0044846055,
-0.014262185,
-0.015429458,
-0.017670082,
-0.011068959,
-0.00006509302,
-0.0020192463,
-0.010310902,
-0.017938422,
0.03279095,
0.017737167,
0.0090228785,
0.0035689005,
0.0011018645,
0.005212473,
-0.024834719,
-0.008258114,
0.003867427,
-0.025626317,
-0.023721114,
0.004628837,
0.010136482,
0.022245253,
-0.025908072,
0.019937541,
-0.00581288,
0.0018280552,
-0.013437045,
0.026538666,
0.014731778,
0.0033659698,
-0.0230771,
0.010780495,
0.029892895,
-0.0004314378,
-0.017361494,
0.024687132,
0.0026297162,
0.00274376,
-0.0026313933,
0.01310833,
0.03440098,
0.02243309,
0.026619168,
0.0128601175,
0.00041236062,
0.019306947,
0.01733466,
0.03139559,
-0.026780171,
0.020541303,
0.012142312,
-0.029195217,
-0.005826297,
0.030912582,
-0.020608388,
-0.03558167,
-0.000926606,
0.003897615,
0.02168174,
0.012571653,
0.016435726,
0.0024586504,
-0.0062422217,
0.014302436,
0.0021433528,
-0.011464758,
-0.015469708,
0.021976914,
0.0033810637,
0.022983182,
-0.008674039,
-0.009774226,
-0.008546578,
-0.012390525,
0.035850007,
-0.0221245,
0.0056652944,
-0.029302552,
-0.0015186275,
0.00042200403,
-0.023238104,
-0.0068560457,
-0.0076141017,
-0.03440098,
0.025747068,
0.0027521455,
-0.012162438,
0.0811992,
0.013765759,
0.011645886,
0.008593537,
-0.023815032,
0.0087813735,
0.010022439,
0.016060052,
-0.022969766,
-0.032817785,
0.02978556,
-0.043229315,
0.022419672,
-0.033193458,
-0.017106572,
0.028604873,
-0.012450901,
-0.009586389,
-0.013886511,
-0.0149866985,
0.028900044,
-0.006520623,
0.022674594,
0.019172778,
-0.013484004,
0.006701751,
0.037862547,
-0.009271091,
0.00091822044,
-0.018448263,
-0.013222374,
0.000080501515,
-0.028551204,
-0.01628814,
0.00022620088,
-0.008137361,
-0.011344005,
-0.020568138,
-0.00037210988,
0.013557797,
-0.0034313772,
-0.003035578,
-0.012397233,
-0.02086331,
0.006124824,
0.010981749,
-0.017173657,
-0.010109649,
-0.013054662
] |
The insulin/IGF-1 (where IGF-1 is insulin-like growth factor-1) signaling pathway influences longevity, reproduction, and diapause in many organisms. Because of the fundamental importance of this system in animal physiology, we asked when during the animal's life it is required to regulate these different processes. We find that in Caenorhabditis elegans, the pathway acts during adulthood, to relatively advanced ages, to influence aging. In contrast, it regulates diapause during development. In addition, the pathway controls longevity and reproduction independently of one another. Together our findings show that life-span regulation can be dissoci | [
-0.0076563824,
-0.007744935,
0.012594885,
-0.027492134,
-0.0011324498,
0.009114092,
-0.021266215,
0.00019860445,
-0.010067734,
-0.019113708,
0.023841048,
-0.0025969713,
0.0098565705,
0.015816832,
-0.005837651,
-0.0037736974,
0.043922022,
0.0012312199,
0.006893469,
0.025039913,
-0.001215042,
0.002002648,
0.02573471,
-0.022560444,
-0.0051735076,
0.014536228,
0.0020588448,
-0.04596554,
0.0074588424,
-0.01166849,
0.0033769142,
-0.024576714,
-0.019249944,
-0.0028490052,
0.008242191,
-0.022424208,
0.012199805,
-0.01107587,
0.012567638,
-0.018282678,
0.031088727,
0.016756851,
-0.016334524,
-0.0031180684,
0.006331501,
0.021906517,
-0.0040189195,
-0.013786938,
-0.012315605,
0.014590722,
-0.003981455,
0.008943799,
-0.028282296,
-0.011443703,
-0.00350804,
-0.005936421,
0.0014193938,
0.008269438,
0.02681096,
-0.0116412435,
-0.008180886,
-0.011804725,
-0.026429504,
0.0035420987,
0.0067061465,
-0.0031197714,
0.017887598,
0.009032352,
0.01553074,
0.008984669,
0.055856172,
0.035775196,
-0.01923632,
0.007186373,
0.005231407,
-0.025870943,
-0.020162715,
0.0047034984,
0.019004721,
0.015721468,
0.03196063,
-0.024072647,
0.007349855,
0.023227993,
-0.0027195825,
0.00089233636,
-0.0070092683,
0.01734266,
-0.010708037,
0.0005585617,
-0.0051769135,
0.0004302032,
0.034930542,
0.043213602,
-0.0039235554,
-0.016893085,
0.0000048892775,
0.024277,
-0.020571418,
-0.014495357,
-0.022928277,
0.006413242,
0.02806432,
-0.012935472,
-0.012710685,
-0.016252784,
-0.0068321633,
0.0032474913,
0.024454104,
-0.016007561,
-0.02061229,
0.051523913,
-0.016606994,
-0.04615627,
-0.0010881736,
-0.0049964027,
0.02633414,
0.007840299,
-0.008071898,
-0.016484382,
0.021116357,
0.022642184,
0.024018154,
-0.022042751,
0.0105173085,
0.030462049,
-0.0011963097,
0.009441055,
-0.027342277,
-0.011940959,
-0.010885142,
0.00033888346,
0.0051428545,
0.018827617,
-0.014399993,
0.0045468286,
-0.002406243,
-0.01111674,
0.01509479,
-0.033922404,
0.008071898,
0.01296953,
-0.045693073,
-0.005858086,
-0.010347015,
0.024181634,
0.023786554,
0.01096007,
0.004110878,
0.015449,
0.0014858082,
-0.007901604,
0.022437833,
-0.02002648,
0.029181443,
0.043268096,
0.016770475,
0.034658074,
0.00942062,
0.0041551543,
0.015380882,
0.0044446527,
-0.004775021,
-0.0019157985,
0.004584293,
0.010748907,
0.0045979163,
-0.002300661,
0.015939444,
-0.00070331094,
-0.010319768,
0.02747851,
-0.010462814,
0.034194876,
-0.027601123,
0.033677183,
-0.007186373,
0.0055924286,
-0.020857511,
-0.0072204317,
0.0012371801,
0.004563858,
0.013643892,
0.01403216,
-0.021811154,
0.00047298937,
0.010748907,
-0.00033398755,
0.015394505,
-0.02416801,
-0.009379749,
0.009686277,
-0.0027876997,
-0.008269438,
-0.6251532,
-0.026756467,
0.019440671,
-0.0196314,
0.02104824,
0.022914654,
0.0020469243,
0.006212296,
-0.0015411535,
0.020721277,
0.0032474913,
0.029181443,
0.008065086,
-0.022723924,
-0.01817369,
-0.037709728,
-0.00090510835,
-0.028173307,
0.0049453145,
0.009727147,
-0.013051271,
0.00085614907,
0.0029358547,
0.026579363,
0.012043135,
0.034739815,
0.028881727,
-0.018623265,
0.02546224,
0.042777654,
-0.011743419,
0.020080974,
-0.0016952688,
0.005796781,
0.034194876,
-0.0043526944,
-0.011695737,
0.008759882,
0.01663424,
0.05416686,
-0.047246147,
-0.003082307,
0.023323357,
-0.005088361,
-0.0275875,
-0.00019189915,
-0.0001414498,
0.0031231772,
0.022492327,
-0.008412484,
0.018051079,
0.035884183,
-0.028963467,
-0.0057661277,
0.02920869,
0.0071795615,
0.018391665,
-0.03582969,
0.012526768,
0.014795073,
0.005425541,
0.029453913,
-0.023636697,
-0.006018162,
-0.017179178,
0.018296301,
0.004335665,
0.0031861858,
0.0021422885,
0.005561776,
0.03027132,
0.020121844,
-0.011007752,
0.015162907,
0.012349663,
0.019563284,
0.0043969704,
0.041851256,
-0.00737029,
0.011654867,
0.00049683044,
-0.0058240276,
-0.007935664,
0.0013878896,
0.005534529,
-0.00335137,
-0.008882494,
0.010135852,
-0.012955907,
0.00032781443,
0.02219261,
-0.0060079442,
-0.012567638,
-0.028609257,
-0.012186182,
0.02207,
-0.0051530725,
0.0046660337,
-0.0067265816,
-0.03716479,
0.0023653726,
0.009195833,
-0.018664135,
0.007738123,
0.029317677,
0.024685703,
-0.036238395,
0.021307085,
0.0450119,
-0.018596018,
0.00506452,
0.010006429,
-0.022247104,
-0.009713524,
-0.0043186354,
-0.017587882,
0.009311632,
-0.0042505185,
0.030216826,
-0.0174244,
0.004577481,
-0.0032083238,
-0.0039780494,
0.00091106864,
0.018500654,
0.032941516,
-0.0120158885,
-0.011109929,
-0.01959053,
0.00092554354,
-0.011280222,
-0.003780509,
0.013051271,
-0.017615128,
0.0097680185,
0.026157036,
0.022178987,
-0.0053233653,
0.021198098,
-0.014154771,
-0.023977283,
-0.026592987,
0.002680415,
-0.009740771,
-0.009550042,
-0.013964043,
-0.02192014,
0.019685894,
0.014318253,
0.005330177,
0.002052033,
-0.009727147,
-0.028663753,
0.028037073,
-0.009672654,
-0.019045591,
-0.009543231,
-0.022832913,
-0.019318061,
-0.004148342,
-0.0034637637,
0.019617777,
-0.039916728,
-0.01052412,
-0.02566659,
-0.02175666,
0.019835752,
0.011123552,
-0.002808135,
-0.021375204,
-0.0014645215,
-0.010646731,
-0.005793375,
0.030870752,
0.0027178796,
0.010020052,
0.009897441,
0.01253358,
-0.0035795632,
-0.006794699,
-0.0005879373,
-0.01363708,
-0.02719242,
-0.016824968,
0.03909932,
-0.0042913887,
0.020557795,
0.021552308,
0.009182209,
0.047709342,
-0.012724308,
0.027955333,
-0.013752879,
0.0056911986,
-0.005987509,
-0.043894775,
0.0097475825,
0.004952126,
-0.004052978,
0.003356479,
0.018745875,
-0.058308393,
0.008787129,
-0.023473214,
0.010054111,
-0.011648055,
0.014795073,
-0.020666784,
0.028691,
0.012663002,
-0.00055387866,
0.021824777,
-0.007193185,
-0.008466978,
0.017329037,
0.017655998,
-0.0238138,
0.010653542,
-0.02396366,
0.008766694,
-0.007642759,
-0.01509479,
0.011280222,
-0.027560253,
-0.0032968763,
0.033322975,
0.005783157,
0.01998561,
-0.006835569,
-0.0049010385,
-0.013194317,
-0.0030516542,
-0.007540583,
0.018786747,
-0.0040393546,
0.01769687,
0.0050474904,
-0.014481734,
0.03689232,
-0.008364802,
0.018854864,
-0.0077040642,
0.036401875,
-0.0040768194,
-0.004560452,
0.009216269,
0.025761956,
0.0053165536,
-0.03828191,
0.008698577,
-0.007240867,
0.015353635,
-0.001151182,
-0.010312957,
0.00867133,
0.011968207,
0.008460166,
-0.003279847,
0.031034233,
0.03256006,
0.01288779,
0.013276058,
-0.008174074,
-0.01482232,
0.015789585,
0.0016688734,
0.008385237,
0.0066516525,
-0.017070191,
-0.007036515,
-0.011436892,
0.009011916,
0.013964043,
-0.0027434235,
0.04119733,
0.008235379,
0.024072647,
-0.021988258,
0.011307469,
0.0044310293,
0.01399129,
-0.02983537,
0.018732252,
0.011579937,
-0.0064302715,
-0.024808314,
-0.012826484,
-0.011239352,
0.018582394,
-0.0010771045,
-0.009727147,
0.0036374629,
0.011545879,
0.0053029303,
-0.006539259,
0.007091009,
0.014127524,
-0.027260536,
0.008678142,
0.006345125,
0.020707654,
0.022001881,
-0.002683821,
0.002074171,
0.038009442,
-0.010667166,
-0.0016893086,
-0.02329611,
-0.0026940384,
-0.0058240276,
-0.010101792,
-0.015980314,
0.0007092712,
-0.03345921,
0.016525252,
0.00006641435,
-0.011239352,
-0.010088169,
0.012315605,
0.009059599,
-0.030380307,
-0.028037073,
-0.011205292,
-0.03228759,
0.04394927,
0.023432344,
0.016320901,
0.019399801,
-0.01269025,
-0.0043663178,
0.002731503,
-0.01178429,
0.03378617,
-0.02077577,
-0.00030525058,
0.0037498563,
0.01241778,
-0.011872842,
0.010319768,
0.017288165,
-0.00044276234,
-0.03716479,
-0.008480601,
-0.0066312174,
0.009080034,
-0.010469626,
0.0068764393,
0.037573494,
0.025639344,
-0.012513145,
-0.0073839133,
0.02175666,
-0.0196314,
-0.008875682,
-0.005333583,
0.0058853333,
0.011975018,
0.04008021,
-0.026184283,
-0.025925437,
0.008698577,
0.030898,
0.024208881,
0.012846919,
0.02912695,
0.004465088,
0.011402833,
-0.011443703,
0.004104066,
-0.032696296,
-0.011934147,
0.030816257,
-0.014999425,
-0.00008504017,
0.033322975,
-0.00776537,
-0.017914845,
-0.032151356,
0.02546224,
-0.0018800369,
0.009733959,
-0.0023159876,
0.003783915,
-0.0074384073,
-0.0074997125,
-0.02408627,
0.033132244,
-0.010653542,
0.014795073,
0.0044718995,
0.0031691566,
-0.013786938,
-0.011212104,
0.009175397,
0.012186182,
-0.036047664,
-0.016593369,
0.005718446,
0.006781075,
0.029317677,
0.012472274,
-0.00811958,
-0.012649379,
-0.0053744535,
0.007887981,
-0.0339769,
-0.005326771,
-0.028527517,
-0.004301606,
0.016266407,
0.030571036,
-0.01880037,
-0.024890054,
-0.009441055,
0.014713333,
0.004281171,
0.022764795,
-0.021198098,
-0.017329037,
0.0020503302,
0.02435874,
0.041497048,
0.013098953,
-0.018732252,
-0.000023069408,
-0.008460166,
-0.039508022,
-0.018023832,
-0.013643892,
-0.00957729,
0.0032594118,
0.01068079,
-0.022955524,
-0.027056184,
0.012485897,
-0.0044446527,
0.0058683036,
0.009836135,
0.025680214,
0.019522414,
-0.0054459767,
-0.0032474913,
-0.0015300844,
-0.003654492,
-0.023582203,
-0.009332067,
0.03212411,
0.017097438,
-0.02999885,
0.012840107,
-0.01399129,
0.021606801,
-0.0273559,
0.016157418,
-0.0033394496,
0.046646714,
-0.004182401,
-0.03760074,
-0.037736975,
0.016021185,
-0.016770475,
0.004185807,
-0.0023670755,
-0.027246913,
-0.0045434227,
-0.024290623,
0.022832913,
-0.023895543,
0.050352294,
-0.03899033,
0.0040427605,
0.011035,
0.01734266,
0.0062463544,
-0.013214752,
-0.006171426,
-0.0039780494,
0.012036324,
-0.020353444,
-0.039862234,
0.010183534,
-0.00425733,
0.026143413,
0.022710301,
0.027137924,
-0.0040393546,
-0.00997237,
0.027328653,
0.014577098,
0.0060454085,
-0.0018664135,
0.0032236504,
-0.017996585,
0.022369714,
0.007240867,
0.012996777,
0.008862059,
-0.018309925,
0.023718437,
0.0075201476,
-0.018160067,
-0.03945353,
-0.015585233,
-0.04533886,
-0.017792234,
0.018813994,
-0.007785805,
-0.0007531217,
-0.016756851,
-0.013398669,
0.024018154,
0.013133012,
0.002128665,
-0.016811345,
0.012492709,
-0.039644256,
0.02266943,
0.00096300803,
0.011028187,
-0.020585041,
-0.02117085,
-0.0018255431,
-0.0021082298,
0.005388077,
-0.019454295,
-0.0022274351,
-0.0024845777,
-0.011934147,
-0.0008680696,
-0.0063042543,
-0.02104824,
-0.011940959,
-0.0140866535,
-0.021729413,
0.008698577,
-0.008453354,
-0.04332259,
-0.04122458,
-0.0012167449,
-0.004029137,
-0.026865456,
0.02841853,
-0.0014926199,
-0.015626105,
0.0043458827,
-0.008378426,
0.0118387835,
-0.009631784,
0.046891935,
0.03582969,
0.015299141,
-0.012165747,
-0.02475382,
0.0031163655,
0.007853922,
0.018010208,
0.02112998,
0.019181827,
-0.03114322,
-0.0013052974,
0.005909174,
-0.0047205277,
-0.030843506,
0.016348148,
0.0047000926,
0.01383462,
-0.006689117,
-0.023187123,
0.0056298934,
0.0008114471,
-0.015149283,
0.008071898,
-0.0017455054,
0.0013189209,
0.010442379,
-0.00055515586,
0.0049044443,
0.022710301,
0.010190345,
-0.0029971604,
-0.009999617,
-0.017669622,
0.004012108,
-0.018364418,
-0.007070574,
0.011654867,
0.003753262,
0.018732252,
-0.013017212,
0.0131262,
0.0083579905,
0.00260208,
-0.0037226095,
0.039235555,
-0.014795073,
-0.0068117282,
0.0051428545,
-0.010176722,
0.0008191103,
-0.0132488115,
-0.0067470167,
0.003230462,
-0.02668835,
-0.006838975,
0.021429697,
0.027206043,
-0.01359621,
0.0069547743,
-0.022560444,
-0.00000745698,
-0.020898381,
-0.018664135,
0.0026514651,
-0.022683054,
0.0065801293,
-0.018391665,
0.02798258,
0.010612672,
0.00681854,
0.0015011346,
-0.01375969,
0.027246913,
-0.0238138,
0.025516734,
0.0031368008,
-0.012949095,
-0.0087122,
0.01403216,
-0.019835752,
-0.012581262,
0.018909357,
0.010496873,
-0.037301023,
0.016620617,
0.008235379,
0.040352676,
0.01557161,
-0.008085521,
-0.009536419,
0.020666784,
0.019358931,
-0.0022121088,
-0.016171042,
-0.0062770075,
-0.012867355,
0.008242191,
0.016770475,
-0.021075487,
0.0074384073,
-0.003811162,
0.00014847438,
0.01052412,
0.0009383155,
-0.02593906,
-0.022437833,
0.0012218538,
-0.0048465445,
-0.011123552,
-0.012717497,
-0.025748333,
-0.03114322,
0.0260208,
-0.026238777,
-0.016484382,
-0.016974827,
-0.003157236,
0.014263758,
0.019454295,
0.0005806998,
0.0060283793,
-0.0053029303,
-0.023881918,
-0.034385603,
-0.016198289,
-0.022342468,
0.02929043,
0.024263376,
0.0063996185,
-0.03228759,
-0.004877197,
-0.02187927,
-0.037900455,
0.00093746406,
0.0016237457,
-0.006072656,
0.0036204334,
0.010217592,
0.025366876,
-0.00044616818,
0.021184474,
0.013657515,
-0.028663753,
-0.015653351,
0.01162762,
0.017873975,
0.008017404,
-0.0022223264,
-0.009311632,
0.0018987692,
-0.034630824,
-0.015898574,
-0.000577294,
-0.018609641,
0.023895543,
-0.007506524,
0.0034245963,
0.0037702916,
0.011995453,
0.0007722797,
-0.022574067,
-0.0032764412,
0.0146588385,
-0.036129408,
-0.018064704,
-0.01990387,
-0.02739677,
-0.00043105468,
-0.0005096024,
-0.0109805055,
-0.017683245,
-0.0016569529,
-0.007956099,
0.016157418,
0.022396961,
0.02286016,
0.0050713317,
0.0015445594,
-0.016211912,
-0.03345921,
-0.0012780505,
-0.018555148,
0.0140866535,
0.00070203375,
0.0018715223,
-0.0031129597,
-0.013902737,
0.013453163,
-0.029235937,
-0.0039439905,
-0.01482232,
0.011007752,
-0.040434416,
0.030053344,
0.005384671,
0.005578805,
-0.012628944,
0.0009740771,
0.0018664135,
-0.03179715,
-0.00013932113,
-0.015993938,
-0.00660397,
0.0029017963,
0.019767635,
-0.018119197,
0.0119273355,
-0.03697406,
0.013950419,
-0.015789585,
0.009877006,
0.1800476,
-0.020871134,
0.018963851,
0.0015718063,
-0.0023892135,
0.0105173085,
0.03934454,
0.0049180677,
-0.008943799,
-0.007165938,
-0.023718437,
0.0051394487,
-0.016266407,
0.00019498571,
0.0034688725,
-0.035775196,
-0.008739447,
0.016865838,
0.0065324474,
-0.015680598,
0.0074043483,
-0.026892703,
-0.00072417187,
-0.0015207183,
0.041251827,
-0.0018238402,
-0.028908974,
-0.0059806975,
0.006130555,
0.012438215,
-0.009427432,
0.0083579905,
0.003204918,
0.026306894,
0.004887415,
-0.0004333962,
-0.022396961,
-0.010449191,
0.015421753,
-0.0020997152,
0.0071999966,
-0.001203973,
0.008031027,
-0.007990157,
0.013242,
0.014018537,
-0.018718628,
-0.03054379,
-0.0026003772,
0.01170936,
-0.053076986,
0.0017744552,
0.018786747,
0.045066394,
0.013691573,
0.0012942284,
0.0041142837,
-0.012084005,
0.006368966,
0.015980314,
-0.028445777,
-0.0018510871,
-0.018078327,
0.013807373,
-0.011600373,
0.03027132,
-0.02448135,
0.018650511,
0.009890629,
-0.018241808,
-0.017369907,
-0.008112768,
-0.01884124,
-0.00721362,
-0.022138117,
-0.010299332,
0.024890054,
0.018514277,
0.02612979,
0.006382589,
-0.0141956415,
0.017669622,
-0.022478703,
-0.00022734143,
-0.012908225,
-0.027955333,
0.03536649,
0.00012665556,
-0.043486074,
0.005190537,
0.022710301,
-0.010551367,
-0.014277382,
-0.009161774,
0.009032352,
-0.03468532,
-0.013582585,
0.006270196,
0.018786747,
-0.0109192,
-0.01698845,
0.07454755,
0.012792425,
0.025843697,
-0.007186373,
0.0022359497,
-0.0070297034,
0.016116548,
0.012451839,
-0.030898,
0.0045536403,
-0.027805474,
0.012465462,
-0.017792234,
-0.008466978,
-0.017329037,
0.023636697,
-0.01994474,
0.01923632,
-0.009740771,
-0.03607491,
-0.010026864,
-0.01012904,
0.02814606,
-0.0062736017,
-0.02254682,
-0.033840664,
-0.0038418146,
-0.015639728,
-0.015939444,
0.0046421927,
-0.008793941,
-0.020707654,
0.003634057,
0.0007931406,
-0.019699518,
0.014100277,
-0.01478145,
0.001902175,
0.015735092,
-0.011109929,
-0.0024726572,
0.0037736974,
-0.016198289,
0.02991711,
-0.016606994,
0.0037226095,
0.017015697,
-0.012765178,
-0.006583535,
-0.0148359435,
-0.0051735076,
0.0020128656,
0.0101426635,
0.03689232,
-0.01269025,
-0.02483556,
-0.036483616,
0.0043492885,
0.004788645,
-0.024549467,
0.004335665,
0.017969338,
-0.004502552,
-0.0016816454,
-0.0075950767,
-0.17241846,
0.008208132,
0.01446811,
-0.01442724,
0.026320517,
-0.0037668857,
0.009693089,
-0.028554764,
0.00010920052,
0.009338879,
0.020503301,
0.0054527884,
-0.050079826,
-0.016307278,
0.0034501404,
0.024426857,
-0.017710494,
0.037001308,
0.0005687793,
0.0015471138,
0.018160067,
-0.045611333,
0.02716517,
-0.0022206234,
-0.01233604,
0.019931117,
0.017942091,
-0.027410394,
-0.00041189668,
-0.027301406,
-0.03335022,
0.020353444,
0.020462431,
-0.00055898743,
0.008814376,
-0.021961011,
-0.017819481,
-0.019849375,
-0.02207,
0.02558485,
0.03582969,
0.014182018,
-0.00068159855,
0.014522605,
-0.011348339,
0.025911814,
-0.009134527,
0.0109192,
0.02456309,
-0.018064704,
0.03008059,
0.009904252,
-0.0064541125,
0.013671138,
0.019522414,
0.0013614942,
0.0074997125,
0.019658647,
-0.007308984,
-0.003950802,
0.0003050377,
0.018119197,
0.041088343,
0.018677758,
0.026865456,
-0.023391474,
-0.0154081285,
0.027737357,
-0.004410594,
0.010885142,
-0.011934147,
-0.022206234,
0.01478145,
-0.023119004,
0.033486456,
0.0062770075,
0.01328287,
-0.0071999966,
-0.00581381,
0.006392807,
-0.010387885,
0.024385987,
-0.028391283,
-0.034930542,
-0.011334715,
-0.010469626,
0.02542137,
0.020803018,
0.005841057,
-0.0028421935,
0.0130717065,
-0.023241617,
-0.0072817374,
-0.016838592,
0.014904061,
0.001777861,
-0.012935472,
-0.014359123,
0.008827999,
0.002607189,
0.022301598,
-0.014372746,
0.0141956415,
0.0025390717,
-0.0011222322,
0.0013870382,
-0.022642184,
-0.004161966,
0.033949655,
0.0064336774,
-0.0016050134,
0.017860351,
-0.01277199,
0.018541524,
-0.012424592,
0.026143413,
-0.019168204,
-0.003429705,
0.0063519366,
-0.017220048,
0.06304935,
0.0130717065,
0.008296684,
0.02700169,
-0.03070727,
-0.029154196,
-0.13623457,
-0.019522414,
0.007390725,
0.028718246,
0.0023466402,
-0.001828949,
0.0060488144,
0.030734517,
-0.012683438,
0.028963467,
-0.026497623,
-0.018459784,
-0.0146588385,
-0.009502361,
0.010374262,
-0.02452222,
0.00023926195,
-0.036320135,
-0.007840299,
0.03245107,
-0.0057286634,
-0.024099894,
-0.0016033105,
-0.00023223735,
-0.023895543,
-0.00616802,
-0.020121844,
0.0018919575,
0.0029137167,
0.014250135,
-0.0059023625,
0.015816832,
0.022655807,
-0.013378234,
-0.010442379,
-0.036592603,
0.0015368961,
-0.008896117,
0.033568196,
-0.016062055,
0.010381074,
0.00003898118,
0.011375586,
0.0010779559,
0.01474058,
-0.009209456,
0.01880037,
0.0027962143,
-0.0003235571,
-0.036728837,
-0.034303863,
-0.017070191,
-0.034630824,
-0.015340012,
0.024331493,
-0.0076155122,
0.011450515,
0.015312765,
0.018732252,
0.011532255,
0.0030993363,
0.028309543,
-0.026579363,
-0.015258271,
0.018228184,
-0.016961202,
-0.031388443,
-0.023677567,
0.00886887,
-0.019140955,
-0.004618352,
0.011695737,
-0.010660354,
-0.00008344367,
-0.03468532,
0.008044651,
0.017942091,
-0.010673978,
-0.015844079,
-0.017506141,
0.002052033,
-0.02597993,
0.009556854,
-0.028309543,
0.0077926167,
-0.0031368008,
0.023432344,
-0.0038384087,
0.011777478,
-0.0048261094,
-0.011613997,
0.017315412,
0.01273112,
-0.017560635,
-0.0026667914,
0.014890438,
0.0070773857,
-0.012778802,
0.012989965,
0.018078327,
-0.02858201,
0.001012393,
-0.038227417,
0.013419105,
0.008126392,
0.0101222275,
0.002581645,
-0.025394123,
0.004730745,
-0.010149475,
0.00867133,
0.0073771016,
-0.014399993,
0.026511246,
0.00636556,
-0.004584293,
-0.013773315,
-0.027369523,
0.03245107,
-0.03035306,
0.012554015,
0.026620233,
0.00091702887,
0.012983154,
0.013459975,
0.0021218534,
0.0005032164,
-0.0048261094,
-0.013024024,
-0.000564522,
-0.010238027,
0.003458655,
0.017996585,
-0.04800906,
-0.017751364,
0.0047852388,
-0.021824777,
-0.008167262,
-0.00626679,
0.03558447,
0.020203585,
0.02885448,
0.0017191098,
-0.017083814,
0.009120904,
-0.033758923,
0.008521472,
-0.008289873,
-0.029780876,
0.010748907,
0.0039644255,
-0.0066312174,
0.016824968,
0.011396021,
-0.0075950767,
-0.0029971604,
0.0040700077,
-0.0010771045,
-0.0011307469,
0.008398861,
-0.0131262,
-0.015639728,
0.012949095,
-0.006130555,
0.0062054843,
-0.016647864,
0.01967227,
-0.029426666,
-0.044058256,
-0.0032628179,
-0.0064779534,
-0.0146588385,
-0.02787359,
0.0066005643,
0.019835752,
0.011831972,
0.0024164605,
0.009073222,
-0.020680407,
-0.0057695336,
-0.01769687,
0.022287974,
0.02117085,
0.004734151,
-0.02641588,
0.02258769,
0.022533197,
0.010782965,
-0.0013725632,
0.013616645,
-0.002254682,
-0.01198183,
-0.0070228917,
0.0028728463,
-0.0018698194,
0.0071999966,
0.035066776,
0.027178796,
-0.014004913,
0.0068764393,
-0.020407937,
0.0068457867,
0.005030461,
0.0031589388,
0.007908416,
-0.02573471,
-0.01107587,
0.006638029,
-0.001827246,
-0.051387675,
-0.011109929,
0.0076768175,
-0.0035659396,
-0.0068287575,
0.005463006,
-0.010871518,
0.003967832,
0.020952875,
-0.01809195,
-0.010619484,
-0.025407746,
0.03212411,
0.024208881,
0.0037157976,
-0.019917494,
-0.0029869429,
0.005483441,
0.008521472,
0.024426857,
-0.0050815493,
0.00630766,
-0.0050202436,
0.02156593,
-0.023827424,
-0.012383722,
-0.01813282,
0.0026770092,
-0.031824395,
-0.0006977764,
0.01513566,
-0.03185164,
0.08773506,
0.011736607,
-0.027342277,
0.01403216,
-0.028473023,
0.02641588,
-0.024277,
0.014713333,
-0.062613405,
-0.008650894,
0.017928468,
-0.02841853,
0.018963851,
-0.039399035,
-0.01178429,
0.02731503,
-0.016920332,
0.006607376,
0.0063212835,
-0.018187314,
0.013391857,
-0.017438024,
0.008705389,
0.014972178,
-0.016007561,
-0.0037498563,
0.03166091,
0.0034245963,
0.010251651,
-0.02637501,
-0.0025492893,
-0.0003578286,
-0.017015697,
0.009052787,
0.020625914,
0.005306336,
-0.012158935,
0.007349855,
0.018936604,
0.023037264,
-0.029889863,
-0.009822512,
-0.018146444,
-0.010203969,
-0.002552695,
0.011021376,
-0.004560452,
0.0049010385,
-0.021184474
] |
OBJECTIVES Non-celiac wheat sensitivity (NCWS) is defined as a reaction to ingested wheat after exclusion of celiac disease and wheat allergy. As its pathogenesis is incompletely understood, we evaluated the inflammatory response in the rectal mucosa of patients with well-defined NCWS. METHODS The prospective study included 22 patients with irritable bowel syndrome (IBS)-like clinical presentation, diagnosed with NCWS by double-blind placebo-controlled challenge. Eight IBS patients not improving on wheat-free diet were used as controls. Two weeks after oral challenge was performed with 80 grams of wheat daily, cells were isolated from rectal biops | [
-0.01982707,
0.008572939,
0.03184431,
0.012732224,
-0.03877416,
-0.03176181,
-0.026633171,
-0.03877416,
-0.0017805863,
-0.0036917948,
0.0042795944,
-0.010724767,
-0.019029588,
0.012677224,
-0.005898622,
0.027485654,
0.04190909,
0.0041524097,
-0.011034136,
-0.004808958,
-0.034346756,
-0.002218858,
-0.0071635945,
-0.0161284,
-0.0043827174,
-0.004014913,
-0.0055067553,
-0.038829155,
-0.0094597945,
-0.011817869,
0.010085406,
-0.005702689,
0.0042211586,
0.019167084,
-0.0069160997,
-0.02124329,
0.017915862,
-0.007644834,
0.0109928865,
0.0015244981,
0.007871704,
0.009322298,
0.003726169,
0.032394297,
-0.036904197,
0.0121409865,
-0.008029826,
-0.015083423,
-0.006919537,
0.0034082073,
0.03459425,
0.0048845815,
-0.03412676,
0.012072238,
-0.008380443,
-0.004520214,
0.017310875,
0.02586319,
0.012931595,
-0.045786507,
0.0047470843,
0.021628281,
-0.012450355,
0.005558317,
0.0047642714,
0.010016657,
-0.004341468,
0.0013019248,
-0.0079267025,
-0.009150426,
0.018685844,
0.03599672,
-0.016747136,
0.0009014648,
0.052358862,
0.004458341,
-0.016692137,
-0.018177105,
0.008153573,
-0.0057576876,
0.015812157,
-0.015289668,
-0.007899203,
0.03731669,
0.011515375,
0.003397895,
-0.0025110391,
0.01792961,
-0.0206933,
-0.01403157,
-0.015592162,
0.021614531,
0.011116634,
-0.009177926,
-0.0065276707,
0.02815939,
-0.0026983789,
0.022178268,
-0.013749702,
-0.023346994,
-0.01666464,
0.015275918,
-0.012024114,
-0.026921915,
-0.006400486,
0.00008271305,
-0.014560934,
-0.020775799,
0.033824265,
-0.010167904,
-0.013660328,
0.008187947,
-0.011212882,
-0.020335808,
0.010181654,
-0.0022154206,
0.042541575,
-0.0038499164,
0.0064520473,
-0.03775668,
-0.0021483907,
-0.0136740785,
0.03921415,
-0.029149367,
0.018025858,
0.0028857186,
-0.04729897,
-0.0016465267,
-0.008882307,
-0.03269679,
-0.0077204574,
0.023085749,
0.044384036,
-0.011714745,
0.0036402335,
0.006537983,
-0.042184085,
-0.0037296065,
-0.018232103,
-0.008229196,
0.018287104,
0.034319256,
-0.010002908,
0.00014490896,
-0.012512228,
-0.00060111977,
0.021353286,
0.038664162,
-0.00021677263,
-0.0032930535,
-0.0069951606,
-0.008524815,
-0.011240381,
-0.024130726,
0.014230941,
0.05348634,
0.026591923,
0.012044739,
-0.011364128,
-0.02399323,
0.00065783726,
-0.041634098,
-0.0021999523,
-0.011020386,
-0.006586107,
0.025560696,
-0.0022876065,
-0.013880324,
-0.0038842906,
0.0031968057,
-0.00049885636,
0.02950686,
-0.016829634,
0.025148204,
0.009961659,
-0.009088553,
-0.004217721,
0.027251909,
-0.0069367243,
-0.00829107,
-0.046831485,
0.015825907,
0.014175942,
-0.015798407,
-0.018644596,
-0.022068271,
0.014244691,
-0.003990851,
0.009755413,
0.0025144767,
-0.001429969,
0.04287157,
-0.008462941,
-0.026784418,
-0.6278664,
-0.020404557,
0.041716594,
-0.0027379093,
0.032889284,
0.02259076,
0.011893492,
0.0059708077,
-0.012464104,
0.014134693,
-0.0020452682,
0.0007515071,
0.010271027,
0.0006763134,
0.003062746,
-0.016059652,
-0.0029544672,
0.015427165,
0.02583569,
0.015509663,
-0.00028831404,
0.015427165,
-0.009927285,
0.021518283,
0.017888362,
-0.009012929,
-0.004131785,
-0.0367942,
-0.00208308,
-0.0026880666,
-0.024089478,
0.03134932,
-0.002392448,
0.020803299,
0.05348634,
-0.008394193,
-0.027843146,
-0.01475343,
0.02444697,
0.019469578,
-0.036161713,
-0.027031913,
0.025574446,
-0.0075348364,
-0.030249344,
0.047023978,
0.0020023002,
0.027856896,
0.0092123,
-0.020583304,
0.0052558235,
0.0019524576,
-0.0024319785,
0.0060567437,
0.04006663,
-0.01564716,
0.013509082,
-0.018589597,
0.0085041905,
0.012051613,
-0.0150009245,
0.028819375,
-0.02945186,
-0.033191778,
-0.01656839,
-0.0030249343,
-0.035226736,
0.0025076019,
0.019538326,
0.017860861,
0.012917845,
0.022879504,
0.007328591,
0.013185964,
0.01082789,
0.028516881,
-0.0013156745,
0.02627568,
-0.006850789,
-0.0033480523,
-0.012299108,
-0.004571776,
-0.00507364,
0.0045442763,
0.030139346,
-0.02803564,
-0.009232924,
0.0059983074,
-0.009611041,
-0.023580737,
0.0060704933,
0.020913295,
-0.012780348,
-0.024666965,
-0.012828471,
0.020473305,
-0.009569792,
0.017599618,
0.02810439,
-0.0013637985,
-0.02484571,
0.0017840238,
0.003504455,
-0.020610802,
-0.005785187,
-0.0054414445,
-0.041166607,
0.0083185695,
0.03041434,
-0.026028184,
0.023236996,
-0.02067955,
-0.034374252,
-0.036271714,
-0.0063557997,
-0.016458392,
0.011817869,
0.0060739308,
-0.031981807,
-0.016705887,
0.018754592,
-0.0053073848,
0.012622226,
-0.0074110893,
-0.03869166,
-0.016719637,
-0.009370422,
-0.0184246,
0.0028032204,
-0.0146159325,
-0.006850789,
-0.007562336,
0.02125704,
-0.0034649249,
0.0067373537,
-0.0144371865,
0.028406883,
0.0016336364,
-0.028544381,
-0.05934371,
-0.031954307,
0.0050530154,
0.0033171156,
0.0020074565,
0.018988337,
0.020514555,
-0.002435416,
0.022645758,
-0.003504455,
0.010140405,
0.022755755,
-0.008978555,
-0.014670932,
0.026468175,
0.0035439855,
0.0073904647,
0.0015545756,
-0.031679314,
-0.015262169,
-0.0064829844,
-0.012017239,
0.009721039,
0.014464686,
-0.007232343,
-0.0013371585,
-0.009494169,
0.011020386,
0.015743408,
-0.0042486577,
-0.02718316,
0.007521087,
0.005042703,
-0.014134693,
0.04375155,
0.001133491,
0.0103604,
-0.021064542,
-0.006180491,
-0.0096454155,
0.018314602,
-0.018053358,
0.0033910202,
-0.00063033786,
-0.0047539594,
0.0059123714,
0.0183971,
0.0069057876,
0.004203971,
-0.018575847,
0.017695867,
0.0017092598,
-0.0073560905,
-0.021903275,
0.01267035,
-0.016279647,
-0.006187366,
-0.0036058591,
0.0003572774,
0.0132890865,
0.02165578,
0.016705887,
-0.012065363,
0.013949072,
-0.0061220545,
0.036161713,
-0.0321468,
0.0055067553,
-0.01522092,
0.028626878,
0.007940453,
0.0028255638,
0.0062526767,
-0.00038026518,
0.0024629154,
0.0049223932,
0.011102884,
-0.018039608,
-0.017173378,
0.0041352226,
0.0028839998,
-0.010291652,
-0.0040733493,
0.014684681,
0.0040217876,
-0.028379384,
0.048068956,
0.0023907293,
0.012807847,
0.008187947,
-0.017847113,
-0.006754541,
0.011357253,
-0.0009684946,
-0.0048330203,
-0.012608476,
-0.007514212,
0.015454665,
-0.009762288,
0.02023956,
0.015702158,
0.0079267025,
0.00989291,
-0.004520214,
0.006926412,
-0.0045683384,
-0.007555461,
0.020459555,
0.0127115995,
-0.012470979,
-0.0042383457,
0.00599487,
0.021820776,
-0.049526423,
-0.010965387,
-0.011577249,
-0.009617916,
0.023841983,
-0.002859938,
0.033411775,
0.024103226,
0.018754592,
-0.0020847984,
0.0037399188,
-0.0014531716,
0.004169597,
-0.014368438,
0.016637139,
-0.0015855124,
-0.009996033,
0.012037864,
-0.020583304,
-0.026014436,
-0.0069126626,
-0.0052248864,
0.0016138712,
0.01221661,
0.02857188,
0.009810412,
0.02157328,
0.00963854,
-0.018809592,
0.006716729,
0.020212062,
0.030001849,
-0.0155784115,
0.004234908,
-0.020487055,
0.000097805496,
-0.003660858,
0.0016697294,
-0.0161284,
0.025588194,
-0.00072271866,
0.0014583278,
0.006287051,
0.01200349,
0.019992067,
-0.018685844,
-0.0019473014,
-0.010387899,
0.014464686,
-0.03352177,
0.018727094,
-0.019483328,
0.022907002,
0.018080857,
-0.004413654,
-0.03041434,
-0.0161284,
0.002966498,
0.0038155422,
-0.008304819,
-0.0060876803,
0.003530236,
0.0036780452,
0.01517967,
0.0028272823,
-0.008614188,
0.036271714,
-0.028819375,
-0.002375261,
-0.06286363,
-0.012161611,
0.0013955947,
0.029094368,
0.0075692106,
-0.015495914,
0.014698431,
0.030139346,
-0.013550331,
-0.023745734,
-0.034759246,
0.016788386,
-0.022315765,
-0.010112906,
0.011639122,
0.027265659,
0.010367275,
-0.006187366,
0.011226632,
-0.008710436,
-0.048536446,
-0.017682116,
0.006338612,
0.010250403,
0.009446045,
0.023168247,
0.03585922,
0.0069057876,
-0.011852243,
-0.020954546,
0.017255876,
0.006991723,
-0.013914698,
0.010023532,
0.021435784,
-0.009336047,
0.007974827,
-0.00424522,
0.0071635945,
0.037564185,
0.013344086,
-0.006204553,
-0.03349427,
0.011955366,
0.0015365292,
0.019332081,
0.0056992513,
-0.019538326,
-0.011577249,
-0.0003660858,
0.03811417,
-0.015770908,
-0.016925883,
0.016760886,
-0.022412013,
-0.0030593085,
-0.03594172,
0.015124672,
-0.009205425,
-0.0052008247,
0.0034889868,
0.009521668,
-0.009205425,
-0.00969354,
-0.0016190273,
-0.0062733013,
0.008222321,
-0.04333906,
-0.014684681,
-0.01754462,
-0.0206933,
-0.011371003,
0.00016735964,
-0.011233506,
-0.0051492634,
-0.00015253575,
0.03129432,
0.022618258,
-0.00020860875,
0.013825325,
-0.008937306,
-0.0049636425,
0.017819613,
-0.0134747075,
-0.012436605,
0.011020386,
0.01286972,
0.027843146,
0.009927285,
0.007452338,
0.0014660619,
-0.023924481,
0.0060154945,
-0.02303075,
-0.018122107,
-0.00044428723,
0.0028083764,
-0.004881144,
-0.0106010195,
0.0014454373,
0.01289722,
-0.02586319,
-0.026646921,
-0.005383008,
-0.0005156138,
-0.017173378,
-0.009631666,
-0.0010423992,
-0.014107194,
0.0019163647,
-0.00027993534,
0.0006479547,
0.0060395566,
0.03497924,
-0.0009650572,
-0.00036651548,
-0.012842221,
-0.0008228337,
0.040176626,
-0.015495914,
0.034786746,
0.018479599,
0.011075385,
0.014368438,
-0.0067304787,
0.020225812,
-0.016348395,
-0.0017444934,
0.01315159,
-0.011529124,
0.00805045,
-0.017654616,
-0.01797086,
-0.023498239,
0.010656019,
0.009391046,
-0.00990666,
-0.020335808,
-0.0048227077,
0.0121341115,
0.034044262,
-0.013639704,
-0.034016762,
-0.0008524815,
-0.012938469,
-0.005427695,
-0.0052798856,
0.025533196,
-0.03178931,
-0.0012821597,
0.015303418,
-0.034759246,
0.0050392654,
0.01084164,
0.015798407,
-0.004970517,
-0.00077299104,
0.0052661356,
-0.024680715,
-0.007431714,
-0.009418545,
0.038884155,
0.02624818,
0.028461883,
0.012017239,
0.021229539,
-0.0013182526,
0.002823845,
0.0028874374,
-0.021312037,
-0.0019490202,
-0.015042174,
0.0055651916,
0.008380443,
-0.012615351,
-0.006232052,
-0.0123334825,
0.0014505935,
0.029754354,
-0.014643432,
-0.018232103,
-0.027265659,
-0.046666488,
0.0077204574,
-0.0067820405,
0.015427165,
0.03456675,
-0.018493349,
-0.004936143,
0.016719637,
0.009666041,
0.015729658,
-0.007768581,
0.034016762,
-0.01979957,
0.021848276,
-0.019950816,
0.017613368,
-0.0026399428,
-0.01152225,
0.010470398,
-0.01934583,
0.007974827,
0.014189692,
0.009349797,
-0.010009782,
0.0015966841,
-0.024529468,
0.0048295828,
-0.026385678,
-0.014327189,
-0.004313969,
-0.0073148413,
0.0011145852,
0.010277902,
-0.018149607,
-0.021807026,
0.009865411,
-0.0025557259,
-0.027004413,
0.023800733,
-0.029974349,
-0.016348395,
0.013598455,
-0.024213225,
0.023168247,
-0.016747136,
0.041606598,
0.021889525,
-0.009150426,
-0.037151694,
0.017558368,
-0.011838493,
-0.017737115,
0.039901633,
0.026921915,
0.009611041,
-0.01473968,
-0.022412013,
-0.004087099,
-0.00853169,
-0.024625715,
0.030001849,
0.012986593,
0.007747957,
-0.034456752,
-0.018809592,
-0.03035934,
0.03640921,
-0.008621063,
-0.0085110655,
-0.005778312,
0.007521087,
-0.013007218,
0.037069194,
-0.031074325,
0.02446072,
-0.005190512,
0.007335466,
-0.019112086,
-0.01710463,
-0.027774397,
0.007802956,
0.018273354,
0.02355324,
-0.022975752,
0.008875432,
0.021037044,
0.0183971,
-0.00088685576,
0.027128162,
-0.0039324146,
0.039901633,
0.006084243,
-0.013357835,
0.0057164384,
-0.0003699529,
0.024790712,
-0.0053383214,
-0.0058367485,
-0.03269679,
-0.021958273,
-0.014368438,
0.026619421,
0.013880324,
-0.006366112,
-0.00045374015,
-0.02213702,
0.012099737,
-0.03365927,
-0.0023288557,
0.002254951,
-0.017118378,
-0.015908405,
0.001381845,
-0.010140405,
0.008524815,
0.004977392,
0.0108072655,
0.005083952,
0.015812157,
-0.019662073,
-0.012257859,
0.0036780452,
0.0071567195,
-0.0072529675,
0.01710463,
-0.007397339,
-0.038939156,
0.033219278,
-0.0067992276,
-0.039984133,
-0.019428328,
0.0052076993,
0.00029604827,
0.018273354,
-0.011797244,
-0.000061981074,
0.049828917,
0.011164757,
-0.0052386364,
-0.007954203,
0.00505989,
-0.018273354,
-0.005077077,
0.007431714,
0.0027705648,
-0.008779184,
0.01129538,
0.0094597945,
0.0011369284,
-0.0060258065,
-0.01927708,
-0.008669186,
0.026440676,
0.0053108223,
0.015138421,
-0.019730821,
-0.010161029,
-0.006562045,
-0.012794097,
0.022659509,
-0.040314123,
-0.0146159325,
-0.012388481,
-0.013069091,
0.014670932,
-0.014217191,
-0.019758321,
-0.031239321,
-0.0065998565,
-0.028379384,
0.0033480523,
-0.024818212,
0.04652899,
0.017805863,
0.0066170436,
-0.04053412,
-0.0020143313,
-0.028186888,
-0.011302255,
-0.013261587,
0.010085406,
0.015605912,
0.007459213,
-0.0036883575,
0.0184246,
-0.040699117,
0.018630845,
-0.025381949,
-0.0051664505,
0.010862264,
-0.007589835,
0.03726169,
0.008731061,
-0.023085749,
0.005042703,
0.010642269,
-0.0006470953,
-0.01058727,
0.0066307937,
0.022247016,
0.0037433563,
-0.013392209,
-0.008957931,
-0.00449959,
-0.010937887,
0.009143552,
-0.003446019,
0.01614215,
0.015069673,
-0.0067820405,
0.013639704,
0.0073423404,
0.02446072,
0.0009951347,
-0.000571472,
-0.019332081,
-0.03635421,
-0.0044549033,
-0.025423199,
0.0038258545,
0.015055923,
-0.0013010656,
0.022027021,
-0.006001745,
-0.010202278,
-0.025643194,
-0.015853405,
-0.016045902,
0.016238397,
0.01564716,
-0.02674317,
-0.021078292,
0.009329173,
-0.000671587,
0.00212261,
0.0092123,
-0.03310928,
0.017352123,
-0.019579574,
0.020913295,
0.02212327,
-0.009473545,
-0.031981807,
0.00474021,
0.002638224,
0.0011266161,
-0.020047065,
0.0035199237,
-0.014244691,
-0.028296886,
0.015468414,
-0.0041111605,
-0.0042486577,
0.00943917,
-0.01313784,
-0.014010946,
-0.004437716,
0.1751162,
0.0049120807,
0.014478436,
0.014354688,
0.0078098304,
-0.010429149,
0.025808189,
0.010078531,
-0.023649486,
0.039791636,
0.033411775,
-0.008105449,
-0.0052730106,
0.005778312,
0.0043655303,
-0.012395356,
-0.03396176,
-0.029121868,
-0.001926677,
-0.025368199,
0.02210952,
-0.007768581,
-0.012360982,
-0.016362146,
0.02716941,
-0.013722202,
-0.0044652154,
0.008731061,
0.04641899,
0.022645758,
-0.01264285,
0.038031675,
0.011047885,
0.008043575,
-0.0008920119,
0.005932996,
0.018658346,
-0.0024818212,
-0.003279304,
0.008593563,
-0.020899545,
-0.02169703,
-0.0123334825,
0.012835346,
-0.014877177,
-0.005032391,
0.00034288317,
-0.006861101,
0.005658002,
0.014093444,
-0.020542054,
-0.006610169,
-0.007046722,
0.025656942,
0.013557206,
-0.0115634985,
0.0096454155,
0.007679208,
-0.006118617,
0.028269386,
-0.008105449,
0.014024695,
-0.020390807,
0.051176388,
-0.00898543,
0.03968164,
0.004654274,
-0.015069673,
-0.0092123,
0.01753087,
0.002034956,
-0.015894655,
-0.0150009245,
0.005276448,
-0.024584467,
0.006001745,
0.028434383,
0.019717071,
-0.017187126,
0.026564423,
-0.0019455828,
0.0073010917,
-0.009301673,
0.02171078,
-0.02576694,
-0.036161713,
0.003079933,
0.00037253098,
-0.024199475,
-0.024034478,
0.00094357325,
0.011336629,
-0.010711017,
-0.032531794,
0.0057886243,
-0.018314602,
0.0034082073,
-0.017035881,
0.0096591655,
-0.007988577,
-0.02803564,
0.09861286,
-0.027815646,
0.019717071,
-0.022742007,
0.020803299,
-0.010463523,
-0.0038499164,
0.004571776,
0.020954546,
0.001582075,
-0.018974587,
-0.012457229,
-0.025395699,
-0.014684681,
0.028929371,
-0.008820433,
-0.023209495,
-0.0138596995,
-0.013646578,
0.00271041,
-0.008160448,
0.0077617066,
0.021738278,
-0.015784657,
0.0047230227,
-0.010236653,
-0.0003985265,
0.012587852,
-0.041551597,
-0.0230445,
-0.024611965,
0.0009581823,
0.0030885267,
0.008538565,
0.0015004362,
0.0070673465,
-0.014313439,
-0.008421692,
0.02399323,
-0.0022102646,
-0.009150426,
-0.014244691,
-0.005108014,
0.025203204,
-0.003636796,
-0.006857664,
0.028489381,
-0.01473968,
-0.006998598,
-0.0067682904,
-0.030689334,
0.006053306,
0.013234087,
0.011034136,
-0.023388242,
-0.024144476,
-0.027911894,
0.014340939,
0.01666464,
-0.025010707,
0.018080857,
0.025656942,
0.0047642714,
0.008394193,
0.013405959,
-0.17456621,
0.038004175,
0.0039702263,
-0.016499642,
0.02484571,
0.002009175,
-0.012374732,
0.018204605,
-0.0013362991,
0.0063317376,
0.021559533,
-0.010099156,
-0.03726169,
0.0059089344,
0.0047711465,
0.01264285,
-0.018273354,
0.016637139,
-0.015908405,
0.014519685,
0.012807847,
-0.006850789,
0.0061942404,
-0.00875856,
-0.015289668,
0.034456752,
0.016472142,
0.025134454,
-0.016884634,
-0.0066514183,
0.00056073,
-0.008181073,
0.036216713,
0.007830455,
0.018232103,
-0.010092281,
-0.034704246,
-0.024116976,
0.0071223453,
0.021738278,
0.021944523,
0.0072048437,
0.033466775,
0.0063283,
-0.023896981,
0.008084824,
0.010167904,
0.013110341,
0.012725349,
-0.0081123235,
0.0071979687,
0.007321716,
0.026495675,
0.015042174,
0.0035199237,
0.012959094,
0.017475871,
0.0076654586,
-0.0020590178,
-0.017159628,
0.019180834,
-0.0029888414,
0.015977154,
-0.0029166555,
-0.010683518,
0.0021638593,
0.018342102,
0.007431714,
0.007424839,
-0.004575213,
0.0048227077,
-0.008428567,
0.0036883575,
-0.025010707,
0.024598217,
0.003086808,
-0.0066686054,
0.012085987,
0.0067992276,
-0.002859938,
-0.016389644,
-0.018713344,
-0.023910731,
-0.008896057,
0.002992279,
0.00072357804,
0.008380443,
0.030056847,
0.01568841,
-0.0006647121,
0.008167323,
-0.020555804,
-0.004671461,
-0.018218355,
0.0021294851,
0.012113487,
0.0005095983,
0.030276842,
0.0027241595,
-0.022205768,
0.013784076,
-0.022329515,
-0.033439275,
0.015550912,
0.0007549446,
0.011109759,
-0.020624552,
-0.017627118,
0.011116634,
-0.004936143,
-0.014780929,
0.01473968,
0.022783255,
0.028186888,
0.00853169,
0.014093444,
-0.009899785,
-0.005001454,
-0.0020246436,
-0.031651814,
0.038911656,
0.020404557,
0.0051423884,
-0.013605329,
0.01706338,
0.002266982,
-0.11725745,
-0.038389165,
-0.0070673465,
0.0016456674,
-0.010271027,
0.01177662,
-0.010222903,
0.01795711,
-0.01608715,
0.011102884,
-0.011611623,
-0.0012770036,
0.013612204,
-0.0153859155,
0.01564716,
0.0034133634,
0.00311087,
-0.0125259785,
-0.0038258545,
0.020858297,
-0.00460615,
-0.012697849,
-0.017833363,
-0.008861682,
-0.0098516615,
0.012677224,
-0.012532853,
0.01979957,
0.009666041,
0.014519685,
-0.01935958,
0.012972844,
0.019510826,
-0.007782331,
-0.0034408628,
0.021985773,
-0.015812157,
-0.029616857,
0.032366797,
-0.008132949,
0.02395198,
0.01472593,
-0.00013599315,
0.008792934,
-0.006345487,
0.006132367,
-0.007988577,
0.0029458737,
0.029396862,
-0.019043336,
0.0010063063,
-0.040314123,
-0.0322018,
0.006152991,
0.020418307,
0.01797086,
0.010642269,
0.034951743,
-0.01564716,
-0.015908405,
0.017255876,
0.0025144767,
-0.04248658,
0.027251909,
0.015894655,
0.023346994,
-0.009473545,
0.00042237365,
0.004420529,
-0.010367275,
-0.013117216,
-0.019964566,
-0.015028424,
0.011116634,
-0.0022343264,
0.0009822443,
-0.0016576984,
-0.013900949,
-0.0016259023,
-0.032779288,
-0.016733387,
-0.02117454,
0.00919855,
-0.024158226,
0.01982707,
0.0064314227,
-0.001193646,
0.009191675,
0.002351199,
-0.024048228,
-0.0022515135,
0.024378221,
0.04553901,
-0.008978555,
-0.00134833,
0.0017591025,
-0.027128162,
-0.018685844,
0.045759007,
-0.007431714,
-0.007184219,
-0.014464686,
-0.0553013,
0.002859938,
0.014698431,
-0.026124433,
0.006885163,
-0.017709615,
0.015042174,
-0.0001550064,
0.0073835896,
0.043669052,
-0.035336733,
0.027251909,
-0.0107935155,
-0.0014136411,
-0.021050792,
-0.015317167,
0.04707898,
0.006249239,
0.0132822115,
0.0067407913,
0.015427165,
-0.020115813,
0.015413416,
0.005317697,
-0.002524789,
0.021092042,
-0.034401752,
0.026206931,
-0.0048261452,
-0.023800733,
0.018658346,
-0.024226975,
0.0007386168,
0.020858297,
-0.0127115995,
-0.010202278,
-0.002471509,
0.035804223,
0.024584467,
0.011343503,
-0.024776962,
-0.035171736,
0.008964805,
0.029149367,
-0.0136740785,
-0.004705835,
-0.02759565,
0.036106717,
0.017214626,
0.0107935155,
0.031431817,
0.007459213,
0.028186888,
-0.025093205,
-0.01519342,
-0.007087971,
-0.0028015017,
-0.012780348,
-0.011151008,
-0.000071971095,
0.030166846,
0.004915518,
0.019620825,
0.013392209,
-0.01754462,
-0.011893492,
-0.020184562,
-0.026633171,
0.0040630368,
-0.022425763,
-0.01473968,
-0.0017565243,
0.015413416,
0.000013883976,
0.0252857,
0.0023821357,
-0.024694463,
-0.005747375,
-0.010752266,
0.02626193,
-0.009136677,
0.0030661835,
-0.034951743,
0.01709088,
0.0032397734,
0.0104153985,
-0.01799836,
-0.0051183263,
-0.00391179,
-0.005977683,
0.017338373,
-0.0002522211,
0.016224647,
-0.0098516615,
0.01754462,
0.02344324,
0.010092281,
0.0028324386,
0.03550173,
0.01313784,
0.0049498924,
0.009253549,
-0.017200876,
-0.03968164,
-0.009810412,
0.010064782,
-0.03874666,
-0.023388242,
-0.009384171,
0.0016173086,
0.011350378,
-0.011219757,
-0.0074454634,
0.003822417,
-0.025986936,
0.010071657,
-0.005472381,
0.021463284,
-0.01665089,
0.014340939,
-0.0053692586,
0.0026175994,
-0.007706708,
-0.0059604957,
-0.017379623,
-0.009102303,
0.024666965,
-0.029259365,
0.026041934,
-0.000079221914,
0.012684099,
-0.013949072,
-0.028214388,
-0.005365821,
-0.0053005097,
-0.011652872,
0.008091699,
0.0038189795,
-0.018342102,
0.07765831,
0.023113249,
0.011783495,
0.007864829,
0.008167323,
0.0067992276,
0.0060945554,
-0.014698431,
0.041606598,
-0.010057907,
-0.0014282502,
-0.008689811,
0.03409926,
-0.040699117,
-0.02576694,
0.013405959,
-0.005011766,
0.011618498,
0.0041420977,
-0.034841742,
0.01887834,
-0.011467251,
0.01985457,
0.010298527,
-0.0018579285,
-0.0058058114,
-0.004386155,
-0.029259365,
-0.008937306,
-0.03632671,
0.0036780452,
0.03376927,
-0.032119304,
-0.007851079,
0.004791771,
-0.020665802,
-0.0022222956,
0.0076585836,
0.02070705,
0.015537162,
0.0072529675,
0.045786507,
-0.024213225,
0.012099737,
-0.021463284,
-0.04097411,
-0.01894709,
-0.017338373,
-0.009975408
] |
We propose a concept for the folding and self-assembly of the pore-forming TatA complex from the Twin-arginine translocase and of other membrane proteins based on electrostatic "charge zippers. " Each subunit of TatA consists of a transmembrane segment, an amphiphilic helix (APH), and a C-terminal densely charged region (DCR). The sequence of charges in the DCR is complementary to the charge pattern on the APH, suggesting that the protein can be "zipped up" by a ladder of seven salt bridges. The length of the resulting hairpin matches the lipid bilayer | [
-0.01624475,
0.0007673658,
-0.014668767,
-0.016002292,
-0.0041218023,
0.041002505,
-0.023949558,
0.008964247,
-0.011146378,
-0.010688399,
0.024178546,
0.009105681,
0.017659094,
0.03257032,
0.011846814,
-0.020784121,
0.009220175,
0.0033556994,
-0.022373574,
-0.01181314,
-0.021538438,
-0.0048794867,
-0.00116515,
-0.016729668,
-0.026993765,
0.015423084,
0.024636524,
-0.030011032,
-0.015153686,
-0.026872534,
-0.00021762376,
-0.0070919245,
-0.02311442,
-0.014264669,
-0.0013773016,
-0.00027276634,
0.0060850466,
-0.012055598,
0.02605087,
-0.010270831,
0.023693629,
0.005007451,
0.0043844664,
0.011570681,
-0.015072865,
-0.016837427,
-0.0048929565,
-0.018898329,
-0.01613699,
0.031358026,
0.015059396,
0.0254986,
-0.012277853,
0.0061119865,
-0.007778892,
-0.017618684,
0.0013200544,
0.0154769635,
0.0075903125,
-0.022656443,
0.008055026,
0.0058223824,
-0.014237729,
0.009125886,
-0.0030879844,
0.010614315,
-0.0022107542,
0.019975925,
0.0058863647,
0.018036254,
0.04366955,
0.03510267,
0.009583864,
-0.013335243,
0.033782616,
-0.010674929,
-0.0254986,
-0.008270545,
-0.022198465,
0.025956579,
-0.0021636095,
-0.013288098,
0.010957798,
0.009900408,
0.019504476,
-0.007873181,
0.01284359,
0.015894532,
-0.015274915,
-0.0009866733,
0.014924697,
0.04000573,
-0.0012990076,
0.028448518,
-0.017012537,
-0.0031250266,
0.00700437,
0.018063193,
-0.009354875,
-0.031169446,
-0.022009887,
0.004216092,
-0.015773302,
-0.02108046,
-0.012917675,
-0.0030357882,
0.020339614,
-0.014278139,
0.014170379,
-0.013207278,
-0.0071660094,
0.043831192,
0.006081679,
-0.033567097,
0.024636524,
0.014641827,
0.008822813,
-0.0006318245,
-0.0013368918,
-0.0027310308,
0.008081965,
0.028771797,
0.012069069,
-0.0023707098,
0.03351322,
0.019895105,
-0.0003245414,
-0.0016189187,
0.006175969,
-0.010876979,
0.030711468,
0.0324895,
0.0014867448,
0.0034095792,
-0.027667262,
0.015328795,
-0.03240868,
-0.011105968,
-0.0073882635,
-0.014399368,
0.007778892,
0.023774449,
-0.024218956,
0.007152539,
0.011213727,
0.027775021,
0.034725513,
0.024852043,
0.0074084685,
0.015463494,
0.013166869,
0.009678153,
-0.010621049,
-0.008836282,
-0.00705825,
0.023868738,
-0.011112702,
0.025054093,
-0.018144011,
-0.010796159,
-0.011308016,
0.020433903,
0.012136418,
-0.006152396,
0.024461415,
0.024905924,
0.020151034,
0.010957798,
0.010668194,
-0.005101741,
-0.0041083326,
-0.016837427,
-0.02105352,
0.005596761,
0.0039399583,
-0.001656803,
-0.0044888584,
0.006559862,
-0.04183764,
-0.02121516,
0.0015860858,
0.012048864,
0.019895105,
0.029903272,
-0.027114995,
-0.026630076,
0.027613383,
0.0034853476,
0.010883713,
-0.022184996,
-0.006997635,
-0.0026603136,
-0.00032896124,
-0.0068966104,
-0.6370744,
-0.020177973,
0.017120296,
-0.031492725,
0.00042009383,
0.012244178,
-0.00044029875,
0.00096141716,
-0.008371569,
0.022238875,
-0.021969477,
0.0008347155,
-0.016958658,
-0.01399527,
-0.01858852,
-0.028475458,
0.012574191,
-0.0059469794,
0.031519666,
0.013240953,
-0.028529339,
0.0006234058,
-0.0207033,
0.0062163784,
0.015638603,
-0.0051892954,
0.022804612,
-0.02601046,
-0.029283654,
0.011530271,
-0.018925268,
0.012991759,
-0.0033220246,
-0.018251771,
0.046067204,
0.0019346204,
0.003141864,
0.026697425,
0.017915023,
0.041137204,
-0.0029886435,
-0.020164505,
0.009314465,
0.031331085,
-0.0062029087,
0.007900122,
0.00407129,
0.009617539,
-0.009886938,
-0.003239521,
-0.0017948698,
0.00037126528,
-0.002690621,
0.007772157,
0.004953571,
0.017416636,
0.015908003,
-0.013793221,
0.016298631,
0.009011392,
-0.0066945613,
0.0037951563,
-0.0038726085,
-0.022723792,
-0.011233932,
-0.0064588375,
-0.027775021,
0.015652074,
0.008391774,
0.013294833,
-0.0043137493,
0.031842943,
-0.0033826393,
0.007933796,
-0.017416636,
0.037931357,
-0.0025239305,
0.0071862144,
0.002985276,
0.025848819,
0.012776241,
0.006761911,
-0.003436519,
-0.010324711,
0.0419454,
0.0071592745,
-0.025175322,
0.029714692,
0.025081033,
0.009698358,
0.007522963,
-0.009597334,
-0.0055428813,
-0.027775021,
-0.024340186,
0.011671705,
-0.007967471,
-0.017712975,
0.012641541,
-0.0126954205,
0.0033169733,
-0.021915596,
0.0015338897,
-0.02332994,
0.026549257,
0.0011819875,
-0.028610157,
0.0077856267,
0.03984409,
-0.0033422294,
-0.03467163,
-0.016864369,
-0.014884287,
-0.026993765,
0.0062130108,
-0.019464066,
0.019208137,
0.026764775,
0.019652646,
-0.02817912,
0.007455613,
0.0073747933,
-0.007832771,
-0.014965106,
0.000634771,
0.033243816,
0.015059396,
-0.021780897,
-0.02338382,
0.0028623627,
0.012621336,
0.008735257,
0.0064150603,
-0.021242099,
0.006442,
0.031627424,
0.010533495,
0.0114292465,
0.0016062906,
-0.026899476,
-0.043615673,
-0.018292181,
0.0040342477,
-0.019262018,
-0.0071188645,
-0.041002505,
-0.015436554,
-0.014534068,
-0.0032125812,
-0.0151132755,
0.0062904633,
0.005007451,
-0.021848246,
0.0014648562,
0.005047861,
-0.0053105247,
-0.013469943,
-0.008028085,
0.003325392,
-0.00919997,
0.0011045353,
0.025134912,
-0.02331647,
0.0049906136,
-0.015301854,
0.0013242638,
0.025431251,
-0.00041020184,
-0.011624561,
-0.042888295,
0.019140787,
-0.03294748,
-0.0126752155,
0.013833631,
-0.018373001,
0.026562726,
0.010674929,
0.002434692,
-0.0047616246,
-0.016972128,
-0.014251199,
-0.005654008,
-0.0005952031,
-0.008654438,
0.016931718,
0.0125607215,
0.028690977,
0.01390098,
0.0048155044,
0.02812524,
-0.009913878,
0.005475532,
0.010708604,
0.026872534,
-0.01291094,
-0.0027141934,
0.048114635,
0.017079886,
0.006229848,
0.020433903,
-0.0048794867,
-0.03203152,
0.0050916383,
-0.03219316,
0.014372429,
-0.008890162,
0.0012611233,
-0.007671132,
0.026886005,
-0.0026552624,
-0.019383248,
-0.013847101,
-0.010297771,
-0.0041083326,
-0.018063193,
0.03313606,
-0.009314465,
0.0052398075,
-0.0046909074,
-0.0046774377,
0.010223687,
0.0040544528,
0.0058863647,
0.009381815,
-0.013698932,
-0.003849036,
0.016514149,
0.004576413,
-0.004007308,
-0.014466718,
0.0116515,
-0.009516514,
-0.001799921,
0.02098617,
0.022723792,
-0.00700437,
-0.011631295,
0.010654724,
0.026845595,
-0.006273626,
0.01650068,
0.0071660094,
-0.00820993,
-0.012614601,
0.007502758,
-0.0032630935,
0.023760978,
0.012217238,
0.0035425948,
-0.0111800525,
0.005755033,
0.028825676,
-0.018898329,
-0.0065430244,
-0.01400874,
-0.009806118,
-0.0006537131,
0.009597334,
0.041729882,
0.0059133046,
0.00522297,
0.015652074,
0.0060109617,
-0.00830422,
0.00008302957,
-0.0012030342,
-0.011079027,
-0.017308876,
-0.012149888,
0.0005872053,
-0.00063561293,
0.0019885004,
0.020164505,
-0.029041195,
0.0012148204,
0.010964533,
-0.009469369,
0.028502397,
0.0018824245,
-0.0011567313,
-0.010802894,
-0.032220103,
0.015247975,
0.015827183,
-0.0056068636,
-0.010243891,
-0.020945761,
0.0037816863,
-0.0065295547,
0.031762123,
-0.019086909,
0.008432184,
0.024919393,
0.006027799,
-0.028583217,
-0.02332994,
0.016110051,
-0.025983518,
0.016770078,
-0.0148438765,
-0.011099232,
0.00010223476,
-0.0071862144,
0.006132191,
0.05188622,
0.021875186,
0.0029246612,
0.0018992618,
0.015571253,
-0.02118822,
0.013375653,
0.012958084,
0.002200652,
-0.009718563,
-0.0015953463,
-0.024057318,
-0.010250626,
0.0043912013,
0.020716771,
0.0058897324,
-0.020137563,
-0.015611663,
-0.01643333,
0.0021972843,
0.026401088,
0.049838785,
-0.005984022,
0.013139929,
0.0036301494,
0.0033826393,
-0.002023859,
-0.038604856,
0.011873755,
0.0047178473,
0.0036503545,
-0.00819646,
-0.019329367,
0.0071121296,
0.021982946,
0.03337852,
-0.008681378,
-0.007745217,
0.014561008,
-0.0009891989,
0.009913878,
-0.021915596,
0.01265501,
0.029687753,
0.01049982,
-0.01040553,
0.018426882,
0.027182344,
0.008768933,
-0.023895677,
0.010250626,
-0.004091495,
0.0186424,
0.00527685,
-0.000042067262,
-0.024340186,
-0.00800788,
0.0058863647,
0.010385325,
0.0041655796,
-0.009146091,
0.022669913,
0.008883427,
-0.009139356,
0.009947552,
-0.022885432,
0.014682237,
0.001964928,
-0.0071053947,
-0.0044686534,
0.019006088,
-0.012446227,
-0.002683886,
-0.025512071,
-0.022535214,
-0.010129397,
-0.006074944,
-0.021956006,
0.0025357166,
-0.010971268,
-0.017780324,
-0.0007084348,
-0.002454897,
-0.002212438,
0.0012257647,
-0.020824531,
-0.005199398,
-0.012203768,
-0.023895677,
-0.026616607,
0.012452962,
-0.041810703,
-0.02828688,
0.00031507039,
0.01300523,
0.019221608,
0.00049922976,
-0.0025020419,
0.021956006,
0.027694201,
-0.015625134,
-0.0077384817,
-0.007482553,
-0.034563873,
-0.0007968313,
0.009072006,
0.01291094,
-0.019194668,
-0.007913591,
0.011927634,
0.009698358,
-0.0062904633,
0.0332977,
-0.0018857919,
-0.01169191,
0.023734039,
0.029687753,
0.033243816,
-0.019410187,
0.005963817,
-0.0037917888,
-0.04676764,
0.00070885575,
-0.008822813,
0.022131115,
-0.0094559,
0.016675789,
0.0027343982,
-0.004970409,
-0.013335243,
0.0004301963,
-0.010257361,
-0.038658734,
0.0050714333,
0.008809342,
0.017295405,
-0.026158629,
-0.0043575265,
-0.035991687,
-0.011375367,
0.0011314752,
-0.021269038,
0.01643333,
0.008068495,
-0.0100081675,
0.009408755,
0.009698358,
-0.014803466,
-0.010163072,
-0.00463366,
-0.01639292,
0.0019329367,
0.0031300779,
-0.017739914,
-0.0062096436,
-0.01609658,
-0.03437529,
0.0017527762,
0.00012585978,
-0.010257361,
-0.013584437,
0.017214587,
-0.012607866,
-0.0011213727,
-0.014358958,
-0.031277206,
-0.0067181336,
0.008782403,
-0.0011769362,
0.018494232,
0.015247975,
0.00579881,
-0.031007808,
-0.026791716,
-0.00095552404,
-0.03962857,
-0.004445081,
-0.0067720134,
0.037850536,
0.034348354,
0.034698572,
0.009031597,
0.014789997,
0.044801027,
0.0032748797,
0.0066878265,
0.013746076,
0.014547538,
-0.013476677,
0.017079886,
0.009745504,
-0.016190872,
-0.0007997778,
-0.025013683,
0.013173603,
-0.0031250266,
0.002076055,
-0.017160706,
0.017160706,
-0.024919393,
-0.025336962,
-0.0033590668,
-0.011840079,
-0.01641986,
-0.031492725,
0.0074084685,
0.013786486,
-0.008964247,
0.013887511,
-0.014251199,
0.041298844,
0.005367772,
0.039386112,
0.0007501074,
0.029148955,
-0.008640968,
-0.0129446145,
-0.015719423,
-0.006246686,
0.03962857,
-0.021565378,
-0.00065455504,
0.0073680584,
0.008014616,
-0.0023723936,
-0.0032361536,
-0.0060075945,
-0.024394065,
0.0001485903,
-0.0041218023,
-0.00937508,
-0.039008953,
-0.011186787,
-0.06417081,
0.0034819802,
-0.007852976,
-0.004078025,
0.004333954,
-0.0036739267,
-0.0030660955,
0.031573545,
-0.015126745,
0.018305652,
-0.0075903125,
0.0163121,
0.02315483,
0.0095097795,
-0.02101311,
-0.024084257,
-0.019706525,
0.00829075,
0.012466432,
0.0326242,
-0.009806118,
-0.017591745,
-0.017349286,
-0.006152396,
-0.028852617,
-0.041810703,
0.0011314752,
-0.00046260832,
0.028960377,
-0.005458694,
0.00018247563,
-0.008270545,
0.015396144,
-0.020622483,
0.004973776,
-0.01419732,
-0.003764849,
-0.030900048,
0.012567456,
0.012345202,
0.033324637,
-0.0062231133,
-0.0052802176,
0.00076989137,
-0.024596116,
0.010196746,
-0.004916529,
0.0076239873,
0.018224832,
0.010365121,
0.008708318,
0.014655298,
0.03483327,
-0.008930571,
-0.006519452,
0.00052869524,
0.039386112,
-0.026630076,
0.013665257,
0.0039904704,
0.01854811,
-0.008405244,
0.007051515,
0.005283585,
-0.016797017,
-0.042672776,
-0.015517374,
0.022737263,
-0.0080887005,
0.000026440024,
-0.023208711,
-0.013476677,
0.027303573,
-0.02140374,
-0.0077384817,
0.010991473,
-0.054714907,
-0.024151606,
0.0055092066,
-0.0021652933,
0.0186424,
0.008970981,
0.005721358,
-0.030926988,
0.050566163,
-0.027748082,
0.019396717,
0.017968902,
0.01270889,
-0.026374146,
0.003926488,
-0.011153112,
-0.02592964,
0.02087841,
-0.011267607,
-0.011941104,
0.006957225,
-0.0107759535,
0.02362628,
0.010573905,
-0.008297484,
0.0041891523,
-0.017645625,
0.012244178,
0.0038254636,
-0.0009925663,
0.009752238,
-0.03006491,
0.019517947,
0.020272262,
-0.007179479,
-0.022602564,
0.010075517,
-0.028421579,
0.016877837,
-0.011132907,
-0.011321487,
-0.012372142,
-0.007307444,
-0.010668194,
-0.010708604,
0.017079886,
-0.0048357095,
-0.006825893,
0.011422511,
0.008411979,
-0.016770078,
-0.019746935,
0.00175446,
0.0024447946,
0.0026300063,
-0.012452962,
-0.010183277,
0.021457618,
-0.0120623335,
-0.03981715,
0.002362291,
-0.022629503,
0.02334341,
0.011435981,
-0.0414066,
0.009880203,
0.005499104,
-0.065787196,
0.0044114063,
-0.0066474164,
0.015813712,
0.012008454,
-0.008445654,
-0.0056910506,
-0.00065034564,
0.010695134,
0.0057954425,
0.016177401,
0.0040342477,
0.016729668,
-0.0135777015,
0.011301282,
0.010722074,
-0.050135124,
-0.015867593,
0.027451742,
0.007718277,
-0.012351938,
0.019194668,
-0.007698072,
0.017739914,
0.0047649923,
-0.005805545,
-0.016621908,
0.013348713,
0.014237729,
-0.0092403805,
0.002140037,
-0.008081965,
0.0053374646,
-0.015247975,
0.015423084,
0.00049670413,
0.008910367,
-0.015153686,
-0.018144011,
-0.03246256,
0.008849752,
-0.004472021,
0.03512961,
0.013261158,
-0.0092403805,
0.012001718,
0.024394065,
-0.0036840292,
-0.011941104,
0.0024128035,
-0.024892453,
-0.03054983,
-0.0002893933,
-0.012156623,
0.017079886,
-0.0019413554,
0.020420432,
-0.018157482,
-0.00089911866,
-0.01399527,
-0.011092498,
-0.017160706,
0.008310954,
0.008445654,
-0.0115235355,
0.0032327862,
-0.009058536,
-0.030792288,
0.0013200544,
0.0050377585,
-0.015975352,
-0.009913878,
-0.00014816936,
-0.009880203,
-0.024070786,
0.010311241,
-0.008553414,
-0.0052667474,
-0.0036671918,
-0.0008460808,
0.2072216,
-0.01179967,
-0.0092605855,
0.018090133,
-0.010183277,
-0.0060345344,
-0.0060345344,
-0.011112702,
0.005118578,
0.0045191655,
-0.010183277,
0.013261158,
-0.00022541107,
-0.010533495,
0.014372429,
-0.001499373,
-0.031223327,
-0.005202765,
-0.017820735,
0.005623701,
-0.0054654293,
-0.007576843,
0.018197892,
0.010371855,
0.040221248,
-0.012304792,
-0.015274915,
-0.030226551,
-0.008822813,
0.015072865,
-0.0324895,
-0.0017165758,
0.012405817,
0.014426309,
0.007522963,
0.018238302,
0.0053441995,
0.015315324,
0.014897756,
-0.0032681448,
-0.011934369,
0.026118219,
-0.011355162,
-0.025808409,
-0.011099232,
-0.0070649846,
0.01390098,
-0.010466145,
0.0039130184,
0.009503044,
-0.026293328,
0.0022949413,
0.017349286,
0.020676361,
-0.027249694,
-0.019262018,
-0.007933796,
0.01166497,
-0.004293544,
0.031411905,
-0.013806691,
0.024649994,
-0.038631793,
0.027236223,
-0.00412517,
0.017403165,
0.0068966104,
0.03044207,
0.033432398,
-0.031331085,
-0.0022949413,
-0.0050849034,
-0.0062668906,
0.014358958,
-0.011348426,
-0.0048424443,
0.024380596,
0.010203482,
0.019625707,
0.021969477,
0.015571253,
-0.01879057,
-0.0072872387,
-0.005805545,
0.0036436194,
-0.019639175,
0.01869628,
0.017039478,
-0.009779179,
-0.017430106,
0.0014539119,
-0.036072508,
-0.0038591386,
-0.004562943,
0.009152826,
-0.0035897396,
0.0051354156,
0.006276993,
0.0010405531,
-0.0052095004,
-0.011765995,
0.02559289,
0.026751306,
0.008789137,
-0.014911226,
0.013847101,
-0.011860284,
0.027222754,
0.026522316,
-0.04272666,
0.007509493,
-0.010001432,
0.012378877,
-0.010560435,
0.009752238,
0.024878984,
0.0020609011,
-0.013139929,
0.05121272,
-0.0021636095,
0.0016214444,
-0.05091638,
-0.004320484,
0.0062096436,
-0.0003365381,
-0.0024060684,
-0.019773876,
0.010715339,
0.0022578991,
-0.047764417,
0.02820606,
0.014561008,
-0.009792648,
-0.010284301,
-0.0066373143,
-0.0102775665,
-0.011341692,
-0.038443215,
-0.014426309,
0.00825034,
-0.01150333,
-0.0008873325,
0.015328795,
0.017537866,
-0.008162785,
-0.02579494,
0.032058463,
0.005616966,
-0.023787918,
-0.023020132,
0.00929426,
-0.009745504,
0.00032517282,
-0.006250053,
-0.0055900263,
-0.034105893,
-0.026064338,
-0.027492153,
0.008081965,
-0.0049198964,
-0.023612808,
0.0011516801,
0.009765708,
-0.028448518,
-0.009711828,
-0.0052364403,
-0.17101438,
0.022279285,
0.015315324,
-0.008964247,
0.022993192,
0.023208711,
0.009610804,
0.013200544,
0.00070001604,
-0.0125809265,
0.022319695,
0.0008010406,
-0.02575453,
-0.017645625,
-0.00707172,
0.010796159,
-0.026697425,
0.005081536,
0.026926415,
-0.0031401804,
0.033163,
-0.03811994,
0.021969477,
-0.008903632,
0.029714692,
0.012008454,
0.0012274485,
-0.0048087696,
0.010176541,
-0.012089273,
0.0131938085,
-0.000045881992,
0.059483267,
-0.005007451,
0.03313606,
0.008513004,
0.007778892,
0.02105352,
0.00064361066,
0.026872534,
0.027074585,
0.020649422,
0.009893673,
-0.026522316,
-0.012345202,
0.021336388,
-0.008903632,
-0.007024575,
0.014736117,
-0.011860284,
0.016904777,
-0.014520598,
0.015194095,
0.034105893,
0.03760808,
0.008688113,
-0.009536719,
0.014305078,
-0.010897184,
-0.004522533,
-0.013476677,
0.0036739267,
0.03992491,
-0.007826037,
0.011334957,
-0.03585699,
-0.0127493,
0.0034651426,
-0.029768573,
0.019733466,
-0.013847101,
0.00019584033,
-0.004923264,
-0.040598407,
0.004401304,
0.015450024,
-0.013725871,
-0.0069033457,
0.016850898,
-0.010762484,
-0.028556278,
0.03246256,
-0.025242671,
-0.014372429,
-0.010627785,
-0.003724439,
-0.033459336,
-0.012291322,
-0.0059604496,
0.008438919,
0.013335243,
-0.028556278,
0.00941549,
-0.012621336,
0.02108046,
0.015679013,
-0.0011331589,
-0.00412517,
-0.004721215,
-0.017901553,
0.013698932,
-0.004131905,
-0.016945187,
0.012264382,
0.016662318,
0.034860212,
0.0048222393,
0.0059099374,
0.030953927,
-0.0014362326,
0.0048424443,
-0.024407536,
0.028771797,
0.041191082,
-0.022360105,
0.021498028,
0.0064184275,
0.0037008666,
-0.000438615,
-0.015786773,
0.06271605,
0.0037345416,
0.0051219454,
0.003436519,
0.0060850466,
-0.006051372,
-0.13513047,
0.004327219,
0.015234505,
0.025996989,
-0.012372142,
-0.013112989,
-0.0063477103,
0.015854122,
-0.018413411,
0.03943999,
-0.021484558,
-0.014695707,
-0.0081089055,
-0.005408182,
-0.0066743563,
0.01040553,
0.0046168226,
-0.0004958623,
-0.030900048,
0.029768573,
0.00472795,
-0.0061692335,
0.021861717,
-0.0013570967,
0.0064622047,
-0.0107759535,
-0.03246256,
0.029445294,
0.009590599,
0.024542235,
-0.0068393634,
0.0021333022,
0.010082252,
-0.00590657,
-0.016406389,
0.0007210629,
-0.0073343837,
-0.004148742,
0.03313606,
0.008411979,
-0.011314752,
-0.0071592745,
-0.008890162,
-0.00040409827,
0.0031654364,
-0.016446799,
0.001806656,
-0.004128537,
-0.0023690262,
-0.0023925984,
-0.004377731,
-0.00020878411,
-0.023895677,
-0.026912944,
0.005569821,
-0.023680158,
-0.00052995805,
0.024340186,
-0.003313606,
-0.02322218,
-0.010634519,
0.009341405,
0.0029684387,
-0.0020945761,
0.04663294,
-0.003613312,
0.0025946477,
-0.025040623,
0.03203152,
-0.0018723219,
-0.0063140355,
0.0149785755,
-0.003980368,
-0.0003613733,
-0.032597262,
-0.005000716,
-0.039224472,
-0.01040553,
0.021376798,
-0.012439492,
-0.011206992,
-0.015126745,
0.0065935366,
-0.015153686,
0.019895105,
-0.0006309826,
0.0123115275,
-0.013847101,
0.026225979,
-0.027613383,
-0.0037311742,
0.041218024,
-0.009994697,
-0.012978289,
-0.008546678,
-0.010809629,
-0.009004656,
-0.00709866,
-0.0033220246,
0.025996989,
-0.035910867,
-0.028987316,
-0.062446654,
0.020299204,
-0.0042194594,
-0.009051802,
0.024057318,
-0.011045353,
-0.0029061402,
0.005569821,
-0.00350892,
0.01635251,
-0.0116515,
0.006004227,
-0.012553986,
-0.034563873,
-0.025013683,
-0.031088628,
0.028556278,
-0.0076239873,
0.031358026,
0.04375037,
-0.008944042,
-0.0054957364,
0.007711542,
0.024272837,
-0.015881062,
0.0016079744,
-0.0009243748,
0.029256715,
0.0008780719,
0.01652762,
0.0026401088,
-0.015126745,
-0.008566883,
0.0033725367,
-0.021915596,
-0.009880203,
-0.021578848,
0.013065844,
0.024690405,
0.0037547464,
-0.023693629,
-0.04226868,
0.010095722,
0.0040679225,
-0.008284015,
-0.004926631,
-0.013698932,
0.0015978719,
0.00089154183,
-0.028556278,
0.027492153,
0.02772114,
-0.006051372,
-0.026266389,
-0.0029768574,
-0.0003293822,
0.008411979,
-0.02557942,
0.007455613,
-0.02579494,
0.024730815,
0.021524968,
0.028933436,
-0.007852976,
0.011914164,
0.014641827,
-0.04175682,
-0.012271117,
0.008836282,
-0.02793666,
-0.0066878265,
0.006128824,
0.0016046069,
0.0054890015,
0.023168301,
-0.010062047,
-0.02351852,
0.00941549,
-0.014439778,
0.004845812,
-0.02366669,
0.004721215,
-0.026374146,
0.014749587,
0.0211074,
-0.0056338036,
-0.0057617677,
0.014264669,
-0.014601418,
0.00707172,
0.0057853404,
0.022871962,
-0.017457046,
0.0016930033,
-0.0040376154,
0.022225404,
0.0042868094,
-0.008634233,
0.006297198,
0.017362757,
-0.011287812,
0.01881751,
-0.012850325,
-0.011341692,
-0.0017847674,
0.0051926626,
-0.014278139,
-0.059914302,
-0.009785913,
-0.0030475745,
-0.00004327745,
-0.0186424,
0.017093357,
0.006310668,
-0.010749014,
0.009994697,
0.0003758956,
-0.009300996,
0.008438919,
-0.0017258364,
0.009907142,
0.014332019,
0.016258221,
-0.0035594322,
0.022737263,
0.010035107,
0.024232427,
0.0034095792,
0.01875016,
-0.0092605855,
0.013335243,
0.018036254,
-0.0042834417,
-0.01899262,
-0.00027929083,
0.018251771,
0.0016180768,
0.027209284,
-0.02592964,
0.10377244,
0.023949558,
-0.011779465,
0.009038331,
-0.0009226911,
0.01639292,
0.01910038,
0.011260872,
-0.0021568746,
-0.02587576,
0.019895105,
-0.0051152105,
-0.0051859277,
-0.019383248,
-0.009927347,
0.015490434,
-0.012958084,
0.021376798,
-0.025269613,
-0.033809554,
0.0043608937,
-0.015840651,
-0.0029802248,
0.010917388,
-0.03246256,
0.0053206272,
0.0154769635,
0.011833345,
0.010190011,
-0.036234144,
-0.0023303,
-0.024003437,
-0.046713762,
-0.010870243,
-0.01060758,
-0.0071053947,
-0.0115235355,
-0.01070187,
0.0010001432,
0.021673137,
-0.0030138995,
0.022656443,
-0.019073438,
-0.02560636,
-0.0033068708,
0.014870817,
0.013773016,
0.0054384894,
-0.026603136
] |
The 137 ribosomal protein genes (RPGs) of Saccharomyces provide a model for gene coregulation. We examined the positional and functional organization of their regulators (Rap1 [repressor activator protein 1], Fhl1, Ifh1, Sfp1, and Hmo1), the transcription machinery (TFIIB, TFIID, and RNA polymerase II), and chromatin at near-base-pair resolution using ChIP-exo, as RPGs are coordinately reprogrammed. Where Hmo1 is enriched, Fhl1, Ifh1, Sfp1, | [
-0.013624844,
-0.034498107,
-0.023707228,
-0.033108372,
-0.041719273,
0.015859319,
-0.006969108,
0.020069394,
-0.02697719,
-0.021241132,
0.022399243,
-0.013597595,
0.00854959,
0.010845376,
-0.0049458183,
-0.012500795,
0.018107418,
-0.021554504,
-0.011185997,
0.015614071,
-0.011056561,
0.006492238,
0.0023996755,
-0.021827,
-0.008488278,
0.03062865,
0.014510459,
-0.026255075,
-0.027590308,
-0.0152462,
0.012166985,
-0.011294995,
-0.0021901936,
0.011478931,
-0.0098167,
-0.018066542,
0.008093157,
-0.0031200892,
0.0048674755,
0.0043497314,
0.027345061,
0.012977663,
-0.0071394183,
0.0052046906,
0.021936,
-0.008651776,
0.0061754608,
-0.0067068296,
-0.017031055,
0.023312109,
0.00058671983,
0.008910648,
-0.012752854,
0.0058859326,
-0.005000318,
0.008188531,
0.0035322409,
0.0045166356,
-0.010954374,
-0.016213564,
-0.011512993,
-0.0060358057,
-0.036460083,
0.025928078,
0.0094420165,
0.018325415,
0.0066250805,
-0.010893063,
0.0018427601,
-0.004768695,
0.038721807,
0.027672058,
-0.020750638,
0.011492556,
0.023639103,
-0.035915088,
-0.028666671,
0.0019432433,
-0.007922847,
-0.005776934,
0.021609003,
-0.007950096,
0.009918886,
-0.0023588012,
-0.0018768222,
-0.008025033,
0.0126166055,
0.0080999695,
0.0034436793,
-0.00338918,
0.049948677,
0.03839481,
0.03727757,
0.018230041,
-0.023216734,
-0.00953739,
0.006471801,
0.015845694,
0.0045745415,
-0.018897658,
0.0013190552,
0.010457068,
-0.017862171,
-0.00782066,
-0.02214037,
-0.003927361,
0.020437267,
-0.011226871,
0.0175488,
-0.026268698,
-0.020137519,
0.040574785,
-0.01487833,
-0.035588093,
-0.006080087,
-0.004952631,
0.032944873,
-0.0071326056,
0.00066634,
-0.01049113,
0.033462618,
0.024565594,
0.009149083,
-0.016785808,
0.03850381,
0.0015379043,
-0.0005190214,
-0.0040499847,
-0.008924273,
-0.008134032,
0.0143742105,
0.0031541514,
0.026091576,
0.00261597,
-0.010872626,
-0.006556956,
-0.016050067,
-0.025396708,
-0.01282779,
-0.036405582,
0.023911601,
0.026513947,
-0.03507035,
0.0062980843,
0.0064479574,
0.0013386409,
0.01088625,
0.011308621,
0.009237644,
0.0027590308,
0.014496834,
-0.015477823,
-0.006134586,
0.010191383,
0.0196879,
0.0048981314,
-0.002937857,
0.02972941,
-0.0020863041,
-0.022099497,
0.009905262,
0.0026415167,
-0.0029123104,
0.017616924,
-0.0038490184,
0.026486697,
0.007888785,
-0.016526936,
0.0093466425,
0.008726712,
0.00371277,
0.0026534384,
-0.025355835,
-0.005732653,
-0.00445873,
0.015545947,
-0.027127065,
-0.0042066704,
-0.02972941,
-0.027317813,
0.010893063,
-0.015259826,
0.040302288,
0.0035731152,
0.011826364,
-0.0048129763,
0.018448038,
-0.0112745585,
-0.013147974,
-0.019265529,
-0.0051399725,
0.015900193,
0.01260298,
-0.0035186158,
-0.6352447,
-0.0261597,
0.036078587,
-0.03839481,
0.0052966583,
0.012929977,
0.022385618,
-0.0058620893,
0.0070304195,
0.029947408,
-0.0012645558,
0.02885742,
0.02962041,
-0.027072566,
-0.031963885,
-0.035533592,
0.015028203,
-0.025832703,
0.03215463,
0.017344426,
-0.023407482,
0.00071317545,
0.025532957,
-0.0005969385,
0.023107735,
0.017712297,
0.03062865,
-0.015287075,
0.005405657,
0.013979089,
-0.017766796,
0.024906214,
-0.016104566,
-0.0026244856,
0.03654183,
-0.0021373974,
-0.01181274,
0.0140335895,
0.046079222,
0.039539296,
-0.013665719,
0.008215781,
0.02301236,
-0.00038660495,
-0.018039294,
0.043763,
0.0005066739,
0.017398925,
0.01664956,
0.013863279,
-0.009673639,
-0.0033483054,
-0.006866921,
0.0013054303,
0.015477823,
-0.0014629676,
0.027099814,
-0.027099814,
0.013291035,
-0.01046388,
-0.0058041834,
0.012023925,
-0.029920157,
-0.0028833577,
-0.0010959484,
-0.011294995,
0.0023281453,
0.0020266955,
0.017303552,
-0.005490812,
0.00046196737,
0.01912928,
-0.0052489713,
0.012337296,
-0.002181678,
0.02573733,
0.0025444396,
0.02491984,
0.0028782482,
0.013086663,
-0.005848464,
0.010770439,
-0.019306405,
-0.024592843,
0.0035458656,
-0.00040257158,
-0.023720853,
0.020628015,
-0.009769013,
-0.016240815,
-0.00038362452,
-0.0029174197,
-0.0022702396,
-0.014687582,
-0.02697719,
0.018134667,
0.006216335,
0.013386409,
0.011438057,
-0.040493038,
-0.013979089,
-0.01066144,
0.009993823,
-0.0065263,
0.014278837,
-0.0038183625,
-0.023734478,
0.01479658,
0.030301653,
-0.010341257,
-0.0010695503,
-0.027276937,
-0.024906214,
-0.0049492246,
0.005228534,
-0.021254757,
0.035533592,
0.012057987,
-0.01580482,
-0.03389861,
0.010136884,
0.00060460245,
0.0040022978,
0.0011606663,
0.012732416,
0.015750319,
0.0026926098,
-0.025968952,
0.003293806,
0.001726949,
0.030737648,
-0.0029429663,
0.016772183,
-0.043490503,
0.0050139427,
0.011002062,
0.020696137,
0.015396073,
0.017276302,
-0.030056406,
-0.02489259,
-0.00874715,
-0.0062674284,
-0.0240751,
-0.0031779949,
-0.029402412,
-0.028911918,
-0.009660014,
0.03681433,
0.004196452,
0.026541196,
0.0240751,
-0.027862806,
0.004615416,
0.0008992397,
-0.0115402425,
-0.04722371,
-0.03321737,
-0.019510776,
-0.0068226405,
0.018597912,
-0.006420708,
-0.007350603,
-0.0033840707,
-0.005858683,
-0.022848863,
0.00445873,
0.014306086,
-0.015518697,
-0.007166668,
0.0062844595,
-0.013113912,
-0.013502221,
0.023530105,
0.0023826447,
0.019701524,
0.0052012843,
0.028939169,
-0.0087607745,
-0.02739956,
-0.018148292,
-0.010293569,
-0.011063374,
-0.0097622005,
0.028094428,
-0.0010184571,
0.02301236,
0.01580482,
0.019265529,
0.023203108,
-0.029102666,
0.014496834,
-0.004714196,
0.022889737,
0.0066863922,
0.010865813,
0.02269899,
-0.002694313,
-0.015668571,
0.021895124,
0.013481783,
-0.023312109,
-0.007105356,
-0.032835875,
0.014483209,
-0.039103303,
0.00050965435,
-0.014224337,
-0.002971919,
0.0013488595,
0.0015115062,
0.0041930457,
-0.0150554525,
0.015327949,
0.005228534,
-0.0061311796,
0.004823195,
0.017140053,
0.0018069949,
0.0062503973,
0.0045575104,
0.000738722,
0.03596959,
-0.000108200424,
-0.003906924,
-0.00029655325,
-0.023897976,
0.018638786,
0.012344109,
-0.0049798805,
-0.02877567,
0.006212929,
-0.0061788666,
0.03302662,
0.01392459,
-0.0029514818,
0.02312136,
-0.024061475,
0.04725096,
-0.0041930457,
-0.008256655,
-0.0007770419,
0.013004914,
-0.01656781,
0.003470929,
0.0006842226,
0.014605832,
0.0044008247,
-0.0068635154,
0.037877068,
-0.014265211,
0.024701843,
-0.002678985,
0.009694076,
0.01395184,
0.013481783,
0.012534857,
0.015232575,
0.017031055,
0.019701524,
-0.009653202,
0.008461028,
-0.00019862468,
-0.029320665,
0.0005909776,
0.007970533,
0.0049390057,
-0.014060839,
-0.033626113,
0.00119558,
-0.024974339,
0.035615344,
-0.01873416,
-0.008236218,
0.019769648,
0.0076980367,
0.0061379923,
0.0029123104,
0.01622719,
0.0011794006,
0.011151935,
-0.021554504,
0.031364392,
0.006410489,
-0.0024167066,
-0.010722753,
-0.04637897,
0.0028475923,
-0.012528044,
0.0007757646,
0.017085554,
0.019878648,
-0.009987011,
0.029293414,
0.006390052,
0.0046426654,
0.022876114,
-0.027276937,
0.01842079,
0.0126166055,
-0.0046460717,
0.012528044,
-0.009183145,
-0.030437902,
0.061475296,
0.007057669,
-0.018230041,
0.0027845774,
-0.006437739,
-0.010722753,
0.024524719,
0.002987247,
0.012071611,
-0.00239116,
0.010784064,
0.0054805935,
-0.0065126754,
-0.005800777,
0.016704058,
0.0038456123,
-0.018379914,
-0.040002543,
0.012766479,
0.008665401,
0.01569582,
0.018121043,
-0.0060324,
-0.0021101476,
-0.009632764,
0.013256974,
-0.003019606,
-0.017126428,
0.017521549,
-0.030192655,
0.00832478,
0.0033312743,
0.02045089,
-0.02106401,
-0.008556402,
0.003842206,
0.0059642754,
-0.030683149,
0.003746832,
0.01440146,
-0.009912074,
0.005068442,
-0.019483527,
0.029838407,
0.010429818,
-0.0025853142,
0.019960396,
0.031773135,
-0.013836029,
-0.01921103,
0.012868665,
0.013427284,
-0.00545675,
0.0018223228,
-0.002130585,
-0.029293414,
0.012044362,
0.0024439564,
-0.0016928868,
0.022044998,
0.021609003,
0.012330484,
0.016744934,
0.01307985,
-0.009285331,
0.002518893,
-0.026282324,
0.005477187,
-0.0035288346,
-0.032835875,
0.009578265,
-0.006165242,
-0.007936472,
-0.011608367,
0.013168411,
-0.023203108,
-0.009694076,
-0.011294995,
0.004577948,
-0.028203428,
-0.0197424,
-0.017739547,
0.014973704,
-0.010075572,
-0.018379914,
-0.004983287,
0.008631338,
-0.013038976,
-0.018352665,
-0.0014765925,
0.0058995574,
-0.04357225,
-0.03583334,
0.001549826,
0.008134032,
0.004816382,
0.009019647,
-0.011356307,
0.0051263478,
-0.007888785,
-0.02354373,
-0.029538661,
0.004792539,
-0.025587456,
-0.024143223,
0.0015685601,
0.015709445,
-0.0054295002,
0.002065867,
-0.010293569,
0.011410807,
-0.014810205,
0.021254757,
-0.0050752545,
-0.0041283276,
0.028666671,
0.03128264,
0.025069714,
-0.0019023689,
-0.011349495,
-0.003920549,
-0.02095501,
-0.017589673,
-0.037304822,
0.013461346,
-0.016363438,
0.010872626,
0.0009835435,
-0.014687582,
-0.008243031,
0.0030553713,
0.005763309,
0.0037400196,
0.016499685,
0.024388472,
0.022399243,
0.007813848,
0.019442651,
-0.0058144024,
-0.016635934,
0.003293806,
-0.009830325,
0.03580609,
-0.0021425067,
-0.05760584,
0.0059336196,
-0.0062197414,
-0.032645125,
-0.0030400434,
-0.006311709,
-0.004577948,
0.054172378,
0.011574305,
-0.00984395,
-0.017712297,
-0.011342683,
-0.013706593,
-0.0070440443,
-0.02264449,
-0.01220786,
-0.016417937,
-0.009224019,
0.010784064,
-0.005712216,
-0.011744616,
-0.02883017,
-0.0033721488,
0.008869774,
0.024211347,
0.016009191,
0.004990099,
0.008842524,
-0.016908431,
0.0012270875,
-0.011567493,
-0.026473071,
-0.0045575104,
-0.016799433,
0.025778204,
0.014823831,
0.033871364,
0.0010346366,
0.00854959,
0.021731626,
0.028339675,
0.014210712,
0.0062878653,
-0.008372467,
-0.031909384,
0.010702315,
-0.00078428007,
0.011349495,
0.00085666205,
-0.02016477,
0.019102031,
0.02880292,
-0.020232894,
-0.013876904,
0.0060324,
-0.032100134,
-0.03599684,
-0.005776934,
-0.0070644817,
-0.016131815,
-0.034334607,
-0.0020556482,
0.010831751,
-0.031228142,
0.018693285,
-0.0036412396,
0.025573833,
-0.006199304,
0.022549117,
0.014333336,
0.031636886,
-0.007875159,
-0.01243267,
-0.010109634,
-0.005919995,
0.026091576,
0.012419045,
0.031119144,
-0.020914136,
-0.010811314,
0.00869265,
0.0030877304,
-0.008147657,
-0.015995568,
0.0016988477,
-0.018393539,
-0.005579374,
-0.01659506,
-0.014742081,
-0.05147466,
0.002081195,
0.012950414,
-0.018161917,
0.014251587,
0.0010584801,
-0.022440119,
0.044008248,
0.013945028,
0.04106528,
0.0065433313,
0.010538816,
0.013229723,
0.0056134355,
-0.02106401,
-0.0137883425,
0.0017022539,
-0.007841098,
0.038067814,
0.01001426,
-0.0027811714,
-0.02092776,
0.0047550704,
-0.010307195,
-0.013849654,
-0.046842214,
0.0021833812,
-0.00007536242,
-0.012384983,
0.0029140136,
0.0049458183,
-0.014782956,
-0.0012585949,
0.0031541514,
0.0063151154,
-0.0077934107,
-0.0017431285,
-0.015327949,
0.0087607745,
0.014074463,
0.0043327003,
0.011799115,
-0.02126838,
0.009939324,
-0.026118826,
-0.0068328595,
-0.002355395,
-0.006281053,
0.05057542,
0.015368824,
0.0018104011,
-0.013733842,
0.016976556,
-0.0019228061,
-0.01392459,
-0.016799433,
0.030056406,
-0.017031055,
0.009115021,
0.0074800393,
0.013025351,
0.00070040213,
-0.004118109,
0.003600365,
0.0307104,
-0.022262994,
-0.0028969825,
0.028039929,
-0.00015987903,
-0.011165559,
0.009380705,
-0.02267174,
-0.0036582707,
-0.005926807,
-0.01960615,
-0.0044178558,
-0.050493672,
0.0063866456,
0.00075617887,
0.041882772,
0.025423959,
0.001267962,
-0.0044008247,
-0.0029974657,
0.012970852,
-0.026268698,
0.02222212,
0.00468354,
-0.017208178,
-0.0197424,
0.0038626431,
-0.027672058,
-0.046133723,
0.008208969,
-0.016581435,
-0.012889102,
0.022835238,
-0.0061482107,
0.0038558308,
0.008188531,
-0.024579218,
-0.0029889501,
0.00894471,
0.016213564,
-0.0002846315,
0.0046562906,
0.00067868753,
-0.013216099,
0.0077865985,
0.025301335,
-0.007997784,
0.011131497,
0.004990099,
-0.007507289,
0.011172372,
0.0045643225,
-0.014455959,
-0.0040567974,
0.0060119624,
-0.015164452,
0.0037536444,
0.013590782,
-0.005507843,
-0.008597276,
0.009006022,
0.0069350456,
-0.018884033,
-0.02447022,
0.020764261,
-0.003859237,
-0.0023451762,
-0.014864705,
0.0120648,
0.011621992,
-0.0024439564,
-0.03302662,
0.020941386,
-0.022617241,
0.049921427,
-0.005085473,
-0.022685366,
-0.021145757,
-0.0012296422,
-0.038967054,
-0.022331119,
-0.0047210082,
0.004680134,
0.008638151,
0.0015046938,
-0.008651776,
-0.007732099,
-0.014973704,
0.01572307,
0.010566067,
-0.020491766,
-0.008733525,
0.005627061,
-0.0026057514,
0.009946136,
-0.035152096,
-0.015178076,
0.031091893,
0.004857257,
-0.0056611225,
0.03408936,
-0.013856466,
0.033816863,
-0.018216416,
0.004877694,
0.006676174,
0.0120648,
0.030328903,
-0.019469902,
-0.015736695,
0.014483209,
0.017807672,
-0.006342365,
0.015218951,
0.0025921266,
0.0010048322,
0.016813057,
-0.0089310855,
-0.025805455,
0.012221485,
-0.01173099,
0.017358052,
0.010770439,
-0.009878011,
0.0021425067,
0.0102731325,
-0.008910648,
-0.008610901,
-0.0061482107,
-0.016254438,
-0.018911283,
0.006829453,
-0.0054976246,
-0.019715149,
-0.00048197884,
-0.007766161,
0.001679262,
-0.017616924,
-0.00015785659,
-0.020846011,
-0.01260298,
0.006056243,
-0.012902727,
-0.015464198,
-0.008304343,
-0.025478458,
0.010259507,
-0.019933147,
0.005323908,
-0.008352029,
0.0058348393,
0.003968236,
0.0030877304,
-0.019388152,
-0.011717366,
-0.0076639745,
-0.003421539,
-0.030083656,
0.02367998,
0.18715085,
-0.010416193,
-0.0064786132,
0.0026432197,
-0.007970533,
-0.01688118,
0.01395184,
-0.013420471,
-0.016785808,
0.012609793,
0.0046460717,
0.021104883,
-0.014455959,
-0.00010484743,
-0.0023962695,
-0.011254122,
-0.02520596,
0.0030144968,
-0.038830806,
0.008399717,
0.010170946,
-0.016704058,
-0.00033913087,
-0.004983287,
0.033844113,
-0.000018068886,
-0.038694557,
0.006407083,
0.00478232,
0.01775317,
-0.022371994,
0.0068056094,
0.007970533,
-0.007636725,
0.008903836,
0.009612327,
0.0047891326,
0.004942412,
-0.011008874,
-0.00013071335,
-0.0037536444,
0.017058305,
0.0061754608,
-0.008570027,
0.004956037,
-0.006761329,
-0.02090051,
0.0013812185,
-0.024565594,
-0.0006373872,
-0.044852987,
0.008924273,
0.00029165682,
0.028639423,
0.028557673,
-0.025750956,
0.022930613,
0.0152462,
-0.015314325,
0.02705894,
-0.0021050384,
0.014142588,
-0.04267301,
-0.0056304666,
-0.022385618,
0.028339675,
-0.03667808,
0.0070644817,
0.01268473,
-0.034498107,
-0.0022804583,
0.0008651776,
-0.0034590072,
-0.0060937116,
-0.0152462,
-0.007813848,
0.02705894,
-0.008631338,
0.01440146,
0.027576685,
-0.0069963573,
0.011076998,
-0.025614707,
0.010225445,
0.011724179,
-0.018611537,
0.030383402,
-0.0014220931,
-0.02106401,
0.004267982,
0.015314325,
0.0011070186,
-0.011894489,
0.004373575,
-0.004455324,
-0.022167621,
-0.01704468,
0.020314643,
0.0010831751,
-0.024960713,
-0.024620093,
0.066216744,
-0.0051535973,
0.0066148615,
-0.016036442,
0.015000953,
0.026459446,
0.019388152,
-0.012521232,
-0.00015253438,
0.0058620893,
-0.042564012,
-0.003082621,
-0.008243031,
0.022903362,
0.003923955,
0.02227662,
-0.037086826,
0.017180929,
-0.00942158,
-0.006955483,
-0.013386409,
-0.005971088,
0.01395184,
-0.025301335,
-0.0037229885,
-0.007827473,
0.011656054,
-0.018488914,
-0.036405582,
0.011458494,
-0.008978772,
0.007071294,
0.0132978475,
0.009264894,
-0.008195343,
-0.0022498025,
0.0008379279,
0.007827473,
-0.0028935762,
-0.022426493,
0.00739829,
0.0024473625,
0.017058305,
-0.015232575,
-0.02143188,
0.0052217213,
0.023134986,
-0.016663184,
0.008426966,
-0.007602663,
-0.009939324,
0.000079087964,
-0.014837455,
0.015518697,
-0.032590628,
-0.0029344507,
-0.047632456,
-0.0051535973,
0.013624844,
-0.042945508,
0.010000636,
0.020014895,
-0.0071871052,
-0.008283905,
0.005919995,
-0.17352602,
0.014660332,
0.0098712,
-0.06529025,
0.021104883,
0.014769331,
0.01290954,
-0.013645281,
0.009823512,
0.0035765215,
0.0038762682,
0.00742554,
-0.03463435,
-0.038040563,
0.0041385465,
0.011315433,
-0.024674593,
0.029293414,
0.021173008,
0.005490812,
0.017644173,
-0.014605832,
0.0011402292,
-0.0020760857,
0.0018546819,
0.0078070355,
0.0017695266,
0.0046937587,
-0.0019500558,
-0.0059676818,
-0.02967491,
0.024429346,
0.028475923,
-0.01527345,
0.012623418,
-0.016486062,
-0.000015673893,
0.008570027,
0.007493664,
0.019020282,
0.01907478,
0.004053391,
0.01375428,
-0.0057735275,
0.0049321936,
0.03681433,
0.009714514,
-0.01063419,
0.017453425,
-0.003951205,
0.007234792,
-0.00046963134,
0.011179185,
0.020382766,
0.029456913,
-0.008713088,
-0.006509269,
0.021282006,
-0.0013607813,
-0.029647661,
-0.009264894,
-0.023066862,
0.03738657,
-0.008352029,
0.013577157,
-0.031691387,
-0.018052919,
0.020873262,
-0.035233848,
0.016118191,
-0.0065842057,
0.0034521949,
-0.0040738285,
-0.0070644817,
-0.000887318,
0.00008850826,
0.0001494475,
0.01198305,
0.003981861,
0.011329058,
0.007977346,
0.018802285,
0.0030076844,
-0.0022157403,
0.0116901165,
0.011649242,
-0.004731227,
0.021336505,
-0.016213564,
-0.007970533,
0.036323834,
-0.008535964,
0.00041832527,
0.0015481228,
0.027263314,
0.008195343,
-0.016022816,
-0.025573833,
-0.0024269253,
-0.0066421116,
0.011390369,
-0.012098862,
-0.024402095,
-0.002484831,
0.042564012,
-0.020287393,
-0.01881591,
0.018039294,
0.05853233,
-0.013113912,
-0.000027702075,
-0.008971959,
0.0039648297,
0.040874533,
0.0013343832,
0.032944873,
0.008392904,
-0.021622628,
0.0044178558,
-0.009837138,
0.06594425,
0.01704468,
0.0023860508,
0.026813693,
-0.0067068296,
-0.014619458,
-0.1135767,
0.0071462304,
-0.013945028,
0.0065160817,
-0.027440436,
0.0111996215,
-0.0029889501,
0.028039929,
-0.014592208,
0.008215781,
-0.02669107,
-0.021173008,
-0.011751428,
0.0017644173,
-0.018448038,
0.010034697,
-0.015000953,
-0.006914608,
0.015818443,
0.014115338,
-0.009087771,
0.00042875682,
0.0005237049,
-0.00045983848,
0.01873416,
0.0008664549,
-0.020001272,
0.0065944246,
0.008127219,
0.023448357,
-0.007350603,
-0.029511413,
0.018189168,
0.008290717,
-0.009905262,
-0.02269899,
0.0014084682,
-0.02126838,
0.043817498,
0.004077235,
0.011254122,
0.0011163857,
-0.004424668,
0.0037332072,
0.008488278,
-0.009162707,
-0.005923401,
0.01330466,
0.015164452,
-0.004339513,
-0.018039294,
-0.037195824,
-0.031718638,
-0.03564259,
0.0077865985,
-0.02053264,
0.024061475,
0.04528898,
0.0047857263,
0.01063419,
0.009837138,
0.0015787788,
-0.0059676818,
-0.0045098234,
0.007534539,
-0.03229088,
-0.0028390768,
-0.03945755,
0.0391578,
-0.02359823,
-0.006669361,
0.0007046599,
-0.020914136,
-0.02354373,
-0.02359823,
0.005627061,
-0.040738285,
-0.03389861,
0.001016754,
-0.0304924,
0.0005317947,
-0.032726876,
0.016908431,
-0.04300001,
0.032563377,
0.019810524,
0.015450573,
-0.0009886527,
0.0000702531,
-0.012514419,
0.0009954652,
0.028693922,
0.009087771,
-0.016908431,
-0.0125416685,
0.032917622,
-0.021949623,
0.0051127225,
0.0078342855,
0.022467367,
-0.032372627,
-0.00844059,
-0.066543736,
0.015477823,
0.0053613763,
0.0050650355,
-0.0020846012,
-0.03141889,
-0.000077597746,
0.0091763325,
-0.004860663,
0.0076162876,
-0.011267746,
-0.0016571217,
-0.0009733248,
0.0149600785,
-0.026077952,
-0.01527345,
0.0479322,
-0.004499605,
0.03234538,
0.02061439,
-0.0074664145,
0.020832386,
0.009373893,
0.03667808,
-0.0038285812,
-0.003242713,
-0.03242713,
0.017984794,
-0.0065160817,
0.015682196,
-0.012085237,
-0.033980362,
-0.014864705,
-0.00049304904,
-0.006866921,
-0.013250161,
-0.0035322409,
0.01181274,
0.022549117,
0.023693604,
-0.004114703,
-0.018161917,
0.0017388707,
-0.005214909,
0.005262596,
0.018557038,
-0.045125484,
0.0078342855,
0.009966574,
-0.026255075,
0.0115402425,
0.013413659,
-0.006509269,
-0.017303552,
-0.025219586,
-0.0023145203,
-0.0092512695,
-0.006826047,
0.0038864866,
-0.015164452,
0.0239661,
0.012255548,
0.008134032,
-0.019715149,
0.0008251546,
-0.00622996,
0.0071871052,
0.019878648,
0.009094584,
-0.03125539,
-0.06185679,
0.01656781,
0.010961187,
0.0132024735,
-0.008208969,
0.015150826,
-0.0126915425,
0.0011223465,
-0.008869774,
0.010702315,
0.027072566,
-0.022181246,
-0.00055989594,
0.028148927,
0.022426493,
-0.009510141,
-0.00030081102,
0.024756342,
-0.005957463,
0.008624527,
-0.009748576,
0.023216734,
0.016377062,
-0.00067826174,
0.023748104,
0.028530423,
-0.0025716892,
0.018911283,
0.007602663,
0.024551969,
-0.01355672,
-0.011853614,
-0.007541351,
-0.020355517,
-0.014360585,
0.0128618525,
-0.017739547,
-0.043899246,
-0.0078002233,
-0.021963248,
-0.002968513,
0.00936708,
0.011874052,
0.0035935526,
0.015791195,
-0.024483845,
-0.025614707,
-0.023925226,
-0.0015447167,
0.0062231473,
0.026786443,
0.022985112,
-0.013325097,
0.0020386174,
0.020723388,
0.01825729,
0.027767433,
-0.027304187,
0.0047005713,
-0.02011027,
0.011969426,
0.0036446457,
-0.029184416,
-0.015763944,
-0.0109339375,
0.0004234346,
0.01026632,
0.031691387,
-0.009823512,
0.09422942,
0.02275349,
-0.015109952,
0.013536283,
-0.0038456123,
0.02179975,
-0.0054805935,
0.014074463,
-0.021091258,
-0.049921427,
0.02227662,
-0.02534221,
0.015968317,
-0.024647342,
-0.008059096,
0.017194552,
-0.0084950905,
0.01797117,
-0.004165796,
-0.023271233,
-0.00032337714,
-0.026118826,
0.005116129,
0.0029140136,
-0.004990099,
0.0027794682,
0.038858056,
-0.0014859595,
-0.00056159904,
-0.024729092,
0.0072552296,
-0.022208495,
-0.038939804,
-0.0131071,
0.017562425,
0.0052864393,
-0.008610901,
0.012814166,
0.029048167,
0.02235837,
0.007296104,
-0.012337296,
-0.008529153,
-0.0025563613,
0.012303234,
0.015082702,
-0.001970493,
0.0028799514,
0.0012415639
] |
Adipose tissue is an important metabolic organ, the dysfunction of which is associated with the development of obesity, diabetes mellitus, and cardiovascular disease. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is considered the master regulator of adipocyte differentiation and function. Although its cell-autonomous role in adipogenesis has been clearly demonstrated in cell culture, previous fat-specific knockouts of the murine PPARγ gene did not demonstrate a dramatic phenotype in vivo. Here, using Adipoq-Cre mice to drive adipose-specific recombination, we report a unique fat-specific PPARγ knockout (PP | [
-0.022300182,
-0.02480684,
-0.011312439,
-0.024897756,
-0.03080724,
0.014533432,
-0.009974688,
0.012026772,
-0.028339542,
-0.018234976,
0.026443314,
-0.00011506445,
0.012143663,
-0.012000796,
-0.023547018,
-0.0033995763,
0.03184627,
-0.003935326,
0.003432046,
0.0035132202,
-0.014611359,
0.014715262,
-0.0194948,
-0.013267114,
-0.0038022003,
0.014507456,
-0.0012444007,
-0.049042214,
-0.018663576,
-0.037924595,
0.011344909,
-0.0077667492,
-0.0074160765,
0.0120072905,
0.028365519,
0.00023418762,
-0.013624281,
-0.00070378045,
0.013961965,
-0.033352863,
0.0106045995,
-0.0032193696,
0.004763303,
0.01576728,
0.00892267,
-0.0015707212,
-0.022962563,
-0.022559939,
-0.00055117294,
0.031222852,
-0.0065783584,
0.018468758,
-0.010286397,
-0.024066532,
-0.018832419,
0.007864159,
-0.016156916,
0.015637401,
-0.004227553,
-0.031820294,
-0.009344776,
-0.015468559,
-0.023365187,
0.0018020676,
0.00022099681,
0.018754492,
-0.0027209597,
0.04400292,
0.010104567,
0.016897226,
0.032677494,
0.022092376,
-0.013351535,
0.006620569,
0.0001309949,
-0.014585383,
-0.02627447,
0.022702806,
-0.014091844,
0.0076433644,
0.020819563,
-0.03135273,
0.014689286,
0.039457165,
0.0033102846,
-0.017611558,
-0.0018231729,
0.014429529,
-0.005990657,
-0.0068056462,
0.015754292,
0.028053809,
0.032911275,
0.011552715,
-0.0099617,
0.010890333,
0.019131139,
0.02059877,
-0.015026971,
-0.015897159,
0.005727653,
0.039145455,
-0.00433795,
-0.012598239,
-0.029794184,
0.0045197806,
-0.02041694,
0.0110332,
0.025248429,
-0.0001781774,
-0.0109682605,
0.06166643,
-0.007948579,
-0.046600495,
0.019027237,
-0.008455106,
0.011344909,
0.0076303766,
-0.028183687,
-0.017585583,
0.012773575,
0.042184617,
0.032547615,
-0.01111762,
0.013650256,
-0.002647903,
-0.0006295061,
0.014416541,
-0.025079586,
0.005919224,
0.0012987875,
-0.0039125974,
0.016182892,
0.015247765,
-0.0020455902,
-0.0048249955,
-0.028469421,
0.007253728,
-0.019767545,
-0.03532702,
0.0007086509,
0.02878113,
-0.021936521,
-0.00035412252,
-0.0058770133,
0.022482011,
0.041093636,
0.004730833,
0.01827394,
0.02096243,
-0.009916242,
-0.005373733,
0.02541727,
-0.0040100063,
0.013728184,
-0.00555881,
-0.00834471,
0.021118285,
-0.012721623,
-0.0040911804,
0.021442981,
-0.013806111,
-0.005315288,
0.018014183,
0.00859148,
0.018481746,
0.014208735,
-0.0024384735,
0.014390565,
-0.005295806,
0.010468227,
0.02065072,
-0.002342688,
0.029248694,
-0.0116436295,
0.025936786,
-0.0047210925,
0.019689618,
-0.010831888,
-0.0019579222,
-0.0060718316,
0.0016478366,
0.018923333,
-0.0024287326,
-0.0021429993,
0.0020764365,
0.014819165,
-0.004357432,
0.011721557,
-0.024235375,
0.0091045005,
0.0071952827,
-0.0164946,
-0.029326621,
-0.62965214,
0.0136112925,
0.013085284,
0.0037859655,
-0.0050100726,
0.047509644,
0.010766949,
-0.0050263074,
-0.012377445,
0.0046106954,
-0.010124048,
0.008208337,
0.026352398,
-0.019235043,
-0.007903121,
-0.028755154,
-0.013987941,
-0.006510172,
0.016520577,
0.0003261174,
-0.0029985756,
-0.014845141,
-0.015689353,
0.0110332,
0.009065537,
0.027014779,
0.02091048,
-0.0001435769,
0.007364125,
0.02872918,
-0.012065736,
0.01955974,
-0.0046399185,
0.003435293,
0.052652843,
-0.0063543175,
-0.013364523,
0.033508718,
0.04454841,
0.04717196,
-0.0071043675,
0.0071173552,
0.02168975,
0.002537506,
-0.012812538,
0.0076044006,
-0.0033995763,
0.0016567658,
0.021728715,
-0.0007942897,
-0.0067082373,
0.003425552,
-0.008045988,
-0.017105032,
0.024962695,
-0.012494336,
0.005909483,
-0.007344643,
0.014819165,
0.008136904,
0.026066665,
0.030547481,
-0.0063965283,
-0.035223115,
-0.03646995,
0.028079785,
-0.01850772,
0.011624148,
0.00036609572,
-0.006000398,
0.014000929,
0.028625276,
-0.0076238825,
0.01203976,
-0.0051399516,
0.01326062,
0.018650588,
0.0338464,
-0.0060685845,
0.03654788,
0.0093123065,
0.009682461,
-0.024832817,
0.016728383,
0.0153256925,
-0.00300994,
-0.015351668,
0.011351403,
0.027897956,
-0.010461733,
0.019598704,
-0.0153776435,
-0.02279372,
-0.021170236,
-0.016793322,
0.013598305,
-0.013637269,
0.010714997,
-0.0013101519,
-0.018183025,
-0.02719661,
-0.003535949,
-0.011676099,
0.012799551,
0.033197008,
0.009377246,
-0.036573857,
-0.0016194256,
0.036625806,
-0.02407952,
0.0059646815,
-0.019390898,
0.0090005975,
0.009370752,
0.0027436886,
-0.018299915,
0.013728184,
-0.0063543175,
0.006425751,
-0.0120592415,
0.027014779,
-0.008974621,
-0.000041880823,
-0.008260288,
0.01888437,
0.021235175,
-0.0028281098,
-0.018468758,
-0.0035327019,
-0.012708635,
0.016169904,
-0.002698231,
0.0066757677,
-0.016936189,
0.010468227,
0.013481414,
0.018962298,
0.0049061696,
0.015624413,
-0.029664306,
-0.028988937,
-0.030755287,
0.00047081045,
-0.016169904,
0.005068518,
-0.0050133197,
0.0060036452,
0.010052615,
0.013124247,
0.010072097,
-0.031508584,
-0.0031593007,
-0.011935857,
0.017572595,
0.017767413,
-0.0022598903,
-0.018403819,
-0.0029774704,
-0.0015731563,
0.021533897,
-0.012117688,
0.0073316554,
-0.019624678,
0.022858659,
-0.023819763,
-0.017520644,
-0.01668942,
0.007052416,
-0.025040623,
-0.012819032,
-0.0026933604,
-0.003019681,
-0.019455837,
0.011286464,
-0.006747201,
0.013702208,
-0.00041967072,
-0.036080316,
0.0033898354,
-0.007032934,
0.0072082705,
-0.0064030224,
-0.029404549,
0.007760255,
0.02119621,
0.00094405614,
0.008805779,
0.032495663,
-0.009227885,
0.010740972,
-0.022092376,
0.025001658,
-0.02041694,
0.02450812,
0.008727852,
-0.051250152,
0.016040025,
0.0027501825,
-0.0041366383,
0.043067794,
0.007448546,
-0.046236835,
0.022482011,
-0.040314365,
0.023754822,
-0.013832087,
0.01662448,
-0.011091645,
0.0033865883,
-0.010273409,
0.0020326024,
0.026677094,
0.008292758,
-0.008370685,
-0.0056107617,
0.017832352,
-0.007162813,
-0.004191837,
0.0036885564,
-0.04504195,
-0.008974621,
-0.0048412303,
0.0061530056,
-0.010552648,
-0.01100073,
0.014572396,
0.019196078,
-0.0030521506,
0.004363926,
-0.02346909,
-0.004993838,
-0.007149825,
-0.00011536886,
-0.002134882,
-0.01791028,
-0.024014581,
0.0014270428,
-0.021468958,
0.018975286,
0.0037275201,
0.016962165,
-0.0020455902,
0.03153456,
-0.00085963495,
-0.025170501,
-0.033534694,
0.012695648,
0.02119621,
-0.028365519,
-0.0013840204,
-0.020455902,
0.0065653706,
-0.011916375,
0.032495663,
0.014871117,
0.0062146983,
0.004753562,
-0.012416408,
0.03753496,
0.018001195,
0.01942986,
-0.0048379833,
-0.029144792,
-0.015780268,
0.0264563,
0.0041593667,
0.022962563,
-0.015286729,
-0.0032908027,
0.005932212,
-0.021222187,
0.002789146,
-0.005182162,
-0.029404549,
0.002745312,
0.013312572,
0.018559674,
0.0012728118,
0.0019644161,
-0.00016924825,
0.010773442,
-0.034885433,
0.03732715,
0.01411782,
-0.008468094,
-0.011091645,
-0.037171297,
-0.028209664,
-0.0121111935,
0.000046041,
0.0052146316,
0.00016224697,
0.011468293,
-0.0004971921,
-0.016910212,
-0.009624016,
0.020196145,
-0.024547083,
0.0345997,
-0.008552516,
0.018481746,
-0.010098073,
-0.012968393,
-0.0028784378,
0.040989734,
0.02426135,
-0.00059013657,
0.0030553977,
-0.0019985093,
-0.018364854,
0.014936056,
-0.012150157,
0.014988008,
-0.007844676,
-0.0108124055,
0.0010503944,
-0.002707972,
0.015234777,
0.0154295955,
0.014377577,
-0.018598637,
-0.019261017,
-0.002178716,
-0.009565569,
0.029612355,
0.029508451,
0.008364191,
-0.008409649,
-0.014702274,
0.0147542255,
-0.022507988,
-0.0090005975,
0.019416872,
0.00028390682,
0.01207223,
0.005893248,
0.0013580447,
-0.00913697,
0.0057438877,
0.0074225706,
-0.017650522,
-0.0131502235,
-0.011085151,
-0.025469223,
0.006204957,
-0.008026507,
0.012922935,
0.026248494,
0.03701544,
-0.011786496,
0.020287061,
0.021157248,
-0.0059451996,
-0.029586378,
-0.012461866,
0.010338348,
-0.014182759,
0.0072991857,
-0.0028281098,
-0.031118948,
0.020455902,
0.0048866877,
0.0058672726,
0.004276258,
0.0054062027,
0.0079096155,
0.025144525,
-0.011292957,
0.019572727,
-0.0046204366,
-0.010909814,
0.021624811,
0.013390499,
-0.017338812,
0.02223524,
-0.017403752,
-0.018364854,
-0.007468028,
0.010630576,
-0.00562375,
0.021326091,
-0.014520444,
-0.0006696873,
-0.0072342465,
-0.0075264736,
-0.008000531,
0.0052341134,
-0.025949774,
-0.0017436222,
-0.011961833,
0.0036723216,
-0.016221855,
-0.01218912,
-0.0004306292,
0.025170501,
-0.03049553,
-0.006182228,
0.018001195,
0.012033266,
0.004961368,
0.0067861644,
-0.022339145,
0.011234512,
0.030651385,
-0.0007679081,
-0.016117953,
-0.004587967,
-0.020442914,
0.002480684,
-0.0021218942,
0.021585848,
-0.045379635,
-0.0055912803,
-0.0036560867,
0.0077277855,
-0.016053014,
0.008747334,
0.007468028,
-0.011585184,
-0.003938573,
0.010903321,
0.021053346,
0.0041756015,
-0.007838182,
-0.026469288,
-0.006104301,
-0.01265019,
-0.033119082,
0.004126897,
-0.016897226,
-0.0037892126,
0.004273011,
-0.02145597,
-0.013767147,
-0.009098006,
0.010299385,
0.0071043675,
-0.0110721635,
0.019235043,
0.021287126,
0.0014806177,
0.03646995,
-0.005578292,
-0.013598305,
-0.022261217,
-0.022975551,
0.023456102,
0.03483348,
-0.020092241,
0.010091579,
-0.032651518,
-0.012020278,
-0.023378175,
0.0099811815,
-0.01329309,
0.020196145,
-0.016053014,
-0.015936123,
-0.034859456,
0.0148061775,
-0.024235375,
0.001306905,
-0.008565503,
-0.004273011,
-0.015130874,
0.015546486,
0.021105297,
-0.019364921,
0.04535366,
-0.035794582,
-0.017377777,
-0.012468359,
0.004971109,
0.032599565,
-0.0073965946,
0.014702274,
-0.016299782,
-0.013767147,
-0.001243589,
-0.02683295,
-0.019533765,
-0.016585516,
0.033586644,
0.039587043,
0.032599565,
0.021287126,
0.0037112853,
0.0047210925,
-0.0030034462,
0.010078591,
0.006032868,
0.018014183,
-0.016286794,
0.017624546,
-0.00081093045,
-0.00214787,
0.022585914,
-0.027482344,
0.0019011002,
0.0051107286,
-0.021702738,
-0.033119082,
-0.0026657614,
-0.0037664836,
-0.029716257,
0.0072732097,
-0.012091711,
-0.008994103,
-0.03244371,
-0.018676564,
0.02310543,
0.010513685,
0.017754424,
-0.009078524,
0.0041204034,
-0.029482476,
0.0277421,
0.019897424,
0.0047210925,
-0.010805911,
-0.02402757,
0.015793256,
-0.016416674,
-0.013072296,
-0.0000824933,
0.026988804,
-0.013533366,
0.0046204366,
0.007987543,
0.0026056925,
-0.018728515,
-0.008026507,
0.01139686,
-0.024858793,
-0.01533868,
0.0007175801,
-0.016338747,
-0.03361262,
-0.0070264405,
0.023547018,
-0.03646995,
0.017001128,
0.00014154754,
-0.023391163,
0.0059451996,
-0.005890001,
0.024780866,
-0.0056919362,
0.04039229,
0.017027104,
0.0029612354,
-0.012877478,
-0.013390499,
-0.0011299452,
-0.006516666,
0.037820693,
-0.02004029,
0.0048639593,
-0.024105495,
-0.016754359,
0.0052503482,
-0.020183157,
-0.008039494,
0.011182561,
-0.011844941,
0.0039320793,
0.0058477907,
0.0094162095,
-0.02652124,
-0.014260687,
-0.016351735,
0.009740906,
-0.014312638,
-0.023560004,
-0.023949642,
0.02976821,
0.0053347694,
-0.0045002988,
-0.012883971,
-0.017936256,
0.024235375,
-0.027040755,
-0.0023816514,
0.0017517396,
0.0050230604,
0.019468823,
-0.014884105,
-0.005802333,
0.017079055,
0.01552051,
0.008695383,
-0.006617322,
-0.02145597,
0.03795057,
0.010676033,
-0.026365386,
0.03140468,
0.010922803,
0.015000995,
0.009857797,
-0.016676432,
-0.018234976,
-0.0061562527,
-0.00015879706,
0.0028800613,
0.023676896,
-0.027534295,
0.0016884237,
-0.015247765,
-0.022520974,
-0.031950172,
-0.019222055,
0.00540945,
-0.027820028,
0.002956365,
0.0030618915,
-0.006532901,
0.0063673058,
-0.0025780932,
0.0037112853,
-0.010942285,
0.022975551,
-0.024599034,
0.031742364,
0.0011729675,
0.019131139,
-0.02053383,
0.017001128,
-0.030469554,
-0.020936454,
0.022170302,
-0.00075573195,
-0.049483802,
-0.020209134,
-0.013546353,
0.019845473,
0.010117554,
0.011780002,
0.030365651,
0.0016932942,
0.01411782,
0.010546154,
-0.007591413,
-0.008981115,
-0.027638197,
0.010987742,
0.016481614,
-0.0049094167,
-0.011741038,
-0.00218521,
-0.029794184,
0.03270347,
0.008390167,
-0.011422836,
-0.0216378,
0.024183422,
-0.032651518,
0.02518349,
-0.009572064,
-0.019897424,
-0.020689685,
0.02084554,
0.018364854,
-0.0044321124,
-0.033456765,
0.0023004774,
-0.00892267,
0.01753363,
-0.020702673,
0.011468293,
-0.009916242,
-0.016286794,
-0.028053809,
-0.008766815,
-0.03646995,
0.01766351,
0.0045100395,
-0.038885698,
-0.023287259,
0.0128385145,
-0.006312107,
-0.030625409,
-0.006640051,
0.023196345,
-0.010143531,
0.022053411,
0.016221855,
-0.012000796,
0.01942986,
-0.0001961372,
-0.027014779,
-0.035119213,
0.015026971,
-0.02365092,
0.031690415,
-0.019325959,
-0.023819763,
-0.022520974,
0.036703736,
-0.02737844,
-0.0015382514,
0.01674137,
-0.022339145,
0.042132664,
-0.032106027,
0.034417868,
0.026209531,
0.010656551,
0.048782457,
-0.023014514,
0.023949642,
0.02114426,
-0.00007295533,
-0.0055685514,
-0.007286198,
-0.00026686024,
0.012208602,
0.0138190985,
-0.007968062,
-0.018053146,
0.0051107286,
0.0013466802,
0.0077342796,
0.00030805616,
-0.011818966,
0.007162813,
0.0020504608,
-0.023027502,
-0.023936654,
-0.023923665,
-0.020313036,
0.020975418,
0.009520113,
0.031092972,
0.00011770261,
-0.008500564,
0.008610961,
-0.038184352,
-0.006454974,
-0.00892267,
-0.009078524,
-0.016130941,
0.027846003,
-0.0146503225,
-0.017105032,
-0.0068121403,
0.0038444109,
0.011741038,
0.0016543305,
-0.015091911,
0.0038086942,
0.013832087,
-0.01436459,
-0.00036812507,
-0.004954874,
-0.006217945,
0.004834736,
-0.033716522,
-0.014572396,
0.025287392,
0.19024639,
-0.01289696,
0.013020344,
-0.0029011664,
0.0013621034,
0.016715394,
-0.011208536,
-0.00023601404,
-0.0142347105,
0.008604467,
0.02114426,
0.0098772785,
-0.016403686,
-0.0026511499,
0.009474655,
-0.021170236,
-0.03324896,
0.000029476389,
-0.011831954,
-0.021352066,
0.008948646,
0.007825195,
0.009110995,
-0.008610961,
0.034859456,
0.0076108947,
-0.015780268,
-0.004464582,
0.015468559,
0.02462501,
-0.024417205,
0.0012744352,
-0.0040359823,
-0.00032530568,
0.022624878,
0.019235043,
-0.03000199,
0.0018653835,
0.015143862,
-0.009331788,
0.017819364,
0.01822199,
-0.0050133197,
0.00580558,
-0.008383674,
0.009052549,
-0.0008210772,
0.016884238,
-0.031248827,
-0.005620503,
-0.038937647,
-0.010344842,
0.0057568755,
0.011942351,
-0.004756809,
-0.00052722654,
0.0042437883,
0.014078856,
0.0071693067,
0.0294565,
-0.02402757,
0.0061659934,
-0.015455571,
0.019962363,
-0.0057990863,
0.030781263,
-0.00788364,
-0.02591081,
0.017027104,
-0.03306713,
0.014702274,
-0.0013604799,
-0.008136904,
0.0074095824,
-0.015039959,
-0.0078576645,
0.038885698,
0.018689552,
-0.009182427,
0.0055685514,
0.008903189,
-0.017286861,
-0.037249226,
0.005825062,
-0.019053211,
-0.027222585,
0.0110332,
0.012104699,
-0.017988207,
-0.011098139,
0.0061302767,
-0.005273077,
-0.017988207,
0.0027712877,
-0.008812273,
-0.035171166,
-0.009494136,
0.0026105628,
-0.0067536947,
-0.016014049,
-0.028209664,
0.088681206,
0.0034515278,
0.019637667,
-0.0076173884,
0.002500166,
0.0038768807,
0.023728848,
-0.0036853096,
0.0025715993,
-0.0057698633,
-0.037716787,
-0.0000016108008,
-0.0051983967,
-0.022209266,
0.020079255,
0.037508983,
-0.0030765028,
0.007955073,
-0.007143331,
-0.012228084,
-0.0063835406,
0.013351535,
0.010663046,
-0.018611625,
0.0029612354,
-0.011059175,
-0.011409848,
0.0041983305,
-0.023053478,
-0.015689353,
-0.020209134,
-0.0034417869,
0.0145464195,
0.012870984,
-0.004373667,
0.009604533,
0.014429529,
-0.0049905907,
0.05309443,
-0.019780533,
0.0070848856,
0.029794184,
0.009513618,
0.020611757,
-0.014247699,
0.019767545,
0.025754957,
-0.0037405079,
0.014039893,
-0.044704266,
-0.017027104,
-0.042028762,
-0.010598105,
0.023598969,
-0.0033378839,
-0.011805979,
-0.042652182,
0.0095331,
-0.004786032,
-0.016897226,
0.0063802935,
0.009578558,
-0.0101889875,
-0.008682394,
-0.011812472,
-0.16198477,
0.019040225,
0.032417737,
-0.028079785,
0.019079188,
0.0019351933,
0.011663112,
0.011137103,
-0.0053445105,
0.00087668153,
0.027326489,
0.005503612,
-0.019261017,
-0.007162813,
0.004087934,
-0.0028362272,
-0.004273011,
0.04223657,
0.0077083036,
0.02457306,
0.018351868,
-0.0041853427,
0.006747201,
-0.010598105,
-0.0010682527,
0.0067926585,
-0.002393016,
-0.013572329,
-0.006831622,
-0.01515685,
-0.014741238,
-0.0038216822,
0.016299782,
0.027508318,
0.0062569086,
-0.008825261,
0.009578558,
-0.014455505,
0.0076368703,
0.017585583,
0.0303137,
0.028469421,
-0.016663443,
-0.013884038,
-0.0109163085,
0.03436592,
0.002071566,
0.013455438,
0.02561209,
0.0028362272,
0.017988207,
0.016273808,
0.0010544531,
0.0152217895,
0.037560932,
0.015741304,
0.0099811815,
0.021442981,
-0.005812074,
-0.00286545,
-0.006312107,
0.0015820855,
0.028755154,
-0.0019059706,
0.013481414,
-0.01985846,
-0.005601021,
0.000017553924,
-0.004523027,
0.00018487428,
-0.021378042,
-0.019248031,
0.010870852,
-0.025936786,
0.015286729,
0.013897026,
-0.01411782,
0.008844743,
0.019105164,
0.0071238494,
-0.001000878,
-0.016481614,
-0.016936189,
-0.009468161,
-0.0048737,
0.014923068,
0.016169904,
0.02683295,
-0.016962165,
0.0037827184,
0.016053014,
-0.025248429,
0.001583709,
-0.017650522,
0.021819629,
0.021715727,
-0.01668942,
-0.009922736,
0.003633358,
0.012559275,
0.026806973,
-0.006740707,
0.004143132,
-0.003057021,
0.020287061,
-0.017949242,
-0.047951233,
-0.0064809495,
0.04761355,
-0.010955272,
0.011922869,
-0.011305945,
0.00081945374,
0.023819763,
0.001265506,
0.010078591,
0.016897226,
-0.02841747,
0.022819696,
-0.025027635,
0.081615806,
0.0057601226,
0.01588417,
0.03569068,
-0.014208735,
-0.018923333,
-0.108059116,
-0.032729443,
0.0058607785,
0.03228786,
-0.0025569878,
0.009474655,
0.007052416,
0.017273873,
-0.010922803,
0.02787198,
-0.017429728,
-0.012325494,
-0.004237294,
-0.0050068256,
-0.019546751,
-0.009474655,
0.022079388,
-0.021092309,
-0.027612222,
0.032469686,
-0.012565769,
-0.029014912,
0.008331722,
-0.020585781,
-0.009117488,
0.016247831,
-0.028625276,
0.009455173,
0.0038736337,
-0.00437042,
0.010598105,
-0.001813432,
0.027975881,
-0.011598173,
-0.024845805,
-0.018209001,
0.011098139,
0.0011737791,
0.01261772,
0.0067926585,
0.014533432,
-0.010689021,
0.0027160894,
0.0032534627,
-0.018196013,
0.0094162095,
-0.009578558,
0.0038638928,
0.012124181,
-0.008156385,
-0.034885433,
-0.017014116,
-0.014780202,
0.0150139835,
0.026365386,
-0.040132534,
0.025573125,
0.010546154,
0.011111127,
0.0081174215,
0.022027435,
0.022897623,
-0.0028281098,
-0.005373733,
0.0285993,
-0.02610563,
-0.0090005975,
-0.044080846,
0.030027967,
-0.026508253,
0.004971109,
0.0074160765,
0.0070004645,
-0.0067082373,
-0.016949177,
0.015312704,
-0.0194948,
-0.02530038,
-0.008734345,
-0.03644398,
-0.013663244,
-0.023417138,
0.012260553,
0.0018345374,
-0.0093123065,
-0.008260288,
0.017988207,
-0.0016462131,
-0.006325095,
-0.012604732,
-0.018053146,
0.03098907,
0.024287326,
-0.01668942,
-0.0149620315,
0.0150139835,
0.010065603,
0.009468161,
0.023300247,
0.019209066,
-0.018806443,
-0.025053611,
-0.050392956,
0.009059043,
0.004065205,
0.018845405,
-0.017689485,
-0.028391493,
-0.0024027568,
0.0014854881,
0.006305613,
-0.021040358,
-0.014416541,
-0.00394182,
-0.0012094958,
-0.01748168,
-0.025703004,
-0.021040358,
0.018403819,
0.008390167,
0.010734479,
0.024300314,
-0.0030765028,
0.033586644,
0.01766351,
-0.0033703535,
0.0024108742,
-0.008812273,
-0.021546884,
0.01218912,
-0.009117488,
-0.012046254,
0.000604342,
-0.03821033,
-0.015559474,
0.0010796171,
-0.0026462795,
0.0009391857,
-0.001007372,
0.0194948,
0.023131406,
0.01955974,
0.00412365,
-0.014182759,
0.019040225,
-0.015819231,
-0.01791028,
-0.009292824,
-0.029118815,
-0.015546486,
-0.00070824503,
-0.0048639593,
0.03361262,
0.02046889,
-0.002657644,
-0.020157183,
-0.011429329,
-0.00053412636,
0.013897026,
-0.0109163085,
-0.029690282,
-0.024897756,
0.038496062,
0.016702406,
0.026858926,
-0.009942218,
0.0149100805,
-0.027456367,
-0.006331589,
0.005928965,
0.0019514282,
-0.02787198,
-0.026988804,
0.018247964,
0.02518349,
0.009526606,
0.007877146,
-0.0084810825,
-0.03911948,
-0.0056334906,
-0.010370818,
0.020949442,
0.01687125,
0.0016981646,
-0.018014183,
0.021378042,
0.029248694,
-0.012052747,
-0.026261482,
0.0004505169,
0.00007493395,
0.017559607,
-0.0063737994,
0.029040888,
-0.0115916785,
0.012721623,
0.0004602578,
0.017650522,
0.018196013,
0.0022582668,
-0.003315155,
0.027794052,
0.016338747,
0.007565437,
-0.0031560536,
-0.01265019,
-0.011150091,
-0.0022809955,
-0.017975219,
-0.027092706,
-0.025339345,
-0.02188457,
0.012507323,
-0.002373534,
0.013481414,
0.0041788486,
-0.0058185677,
0.00766934,
-0.0022907364,
-0.012143663,
-0.015234777,
0.018053146,
0.031950172,
0.0013775264,
-0.005893248,
0.0028102514,
-0.007597907,
0.015975086,
0.020131206,
-0.038496062,
0.02639136,
-0.010494203,
0.025261417,
-0.021092309,
-0.020585781,
-0.015130874,
-0.006948513,
-0.01032536,
0.022014448,
0.028703203,
-0.015351668,
0.08249898,
0.014325626,
-0.01718296,
-0.008610961,
0.00663031,
0.025754957,
0.0012379069,
-0.00383467,
-0.027846003,
-0.011241006,
0.011474787,
-0.019092176,
0.024040556,
-0.034236036,
-0.03231383,
0.024001593,
-0.01111762,
0.0063867876,
0.0018507722,
-0.018079123,
0.017040092,
-0.026469288,
-0.0038444109,
0.0028410975,
-0.03961302,
-0.02119621,
0.052419063,
0.009598039,
0.008864225,
-0.026508253,
0.0077407733,
-0.014780202,
-0.035093237,
0.011189054,
0.016715394,
-0.037171297,
0.0019319464,
-0.017014116,
0.010137036,
0.026495265,
0.014000929,
0.019286994,
-0.023170369,
-0.02670307,
-0.003422305,
0.013559341,
-0.012559275,
-0.020546818,
-0.023066465
] |
PURPOSE OF REVIEW Owing to the high mortality, risk of neurodevelopmental impairment and end-organ involvement with fungal infections in the neonate, prevention of invasive Candida infections in extremely preterm infants should be a priority for each neonatal ICU. RECENT FINDINGS Even with prompt or empiric treatment, mortality and neurodevelopmental impairment is high (57%) in infants <1000 g. Multiple studies have been performed with fluconazole prophylaxis, including a recent multicenter randomized controlled trial. All of the studies have demonstrated efficacy and safety with no increase or emergence of fungal resistance. Analysis of these studies demonstrates that flu | [
0.016850833,
-0.025551502,
0.018623192,
-0.03539346,
-0.013037576,
0.012319234,
-0.01699853,
-0.00031175718,
-0.0047262893,
-0.008029321,
0.016045215,
0.015615553,
-0.005458059,
0.018945439,
-0.02718959,
0.0051123146,
0.055909853,
0.007458675,
-0.022060493,
0.007921905,
-0.028465152,
0.012789178,
-0.027082175,
-0.025430659,
-0.022906391,
0.005686317,
-0.00613612,
-0.034856383,
-0.0015801851,
-0.0023732148,
-0.0048538456,
-0.00058113557,
0.012883167,
-0.005854154,
-0.0061529037,
-0.016931394,
0.023953693,
0.00005507151,
-0.0130174365,
-0.004568523,
0.01638089,
0.0070222993,
-0.011177943,
0.0073445463,
0.013883475,
0.004326837,
-0.01752218,
-0.003086522,
-0.00889536,
0.0031419082,
0.012943588,
0.013715638,
0.007183423,
0.013789486,
-0.01991218,
-0.015991507,
0.010835555,
0.011701594,
-0.001560884,
-0.03270807,
-0.002301045,
0.009660697,
-0.029431893,
0.031848744,
0.0159378,
0.0186769,
-0.0053271456,
0.009224321,
0.0019217334,
-0.0014736087,
0.023940267,
0.046054468,
0.012614627,
-0.012057409,
0.023819424,
0.011171229,
-0.022597572,
-0.0018898444,
0.0076265126,
0.017924989,
0.024195379,
-0.007606372,
-0.03853537,
0.019603359,
-0.0024621685,
0.005679603,
0.0032006511,
0.021697965,
-0.004101936,
-0.013299402,
-0.00812331,
0.0014417197,
0.031284813,
0.015575272,
0.0101977745,
0.009439152,
-0.009788252,
0.028814252,
0.013232267,
-0.0067638303,
0.0075728046,
-0.0012654908,
-0.009063197,
-0.026558524,
-0.0023765715,
0.002410139,
-0.01518589,
0.0019166983,
0.018542629,
-0.018529203,
-0.0020073303,
0.03380908,
-0.0033517045,
-0.024557907,
0.0038199697,
0.009694264,
0.020932628,
0.016971676,
-0.0049814014,
-0.017669877,
0.01752218,
-0.00038539566,
0.025538076,
-0.022785548,
0.023362909,
0.0009675802,
-0.033916496,
-0.016085496,
-0.013829767,
-0.029512454,
0.0039508827,
-0.0045953766,
0.040898517,
0.00044854434,
0.0031268029,
0.01536044,
-0.026451107,
-0.007747355,
-0.021509988,
-0.022718413,
0.022745268,
0.037944585,
-0.007539237,
-0.0061562606,
-0.013030863,
0.021926222,
0.013601509,
0.028357737,
0.0002668608,
-0.010076933,
0.011372634,
-0.029029084,
0.0041321465,
0.00966741,
0.0044241827,
0.0073714,
0.003190581,
0.034265596,
-0.022073919,
-0.0010372326,
-0.023067515,
-0.023644874,
-0.015024766,
0.01624662,
-0.00037931156,
0.021456279,
0.012473645,
-0.0018008908,
0.027404422,
0.00017969047,
0.0051123146,
0.028679984,
-0.011728448,
0.02564549,
-0.0038535371,
0.008687242,
0.0033600964,
0.0159378,
-0.004605447,
-0.022409594,
-0.005951499,
0.004769927,
0.023752289,
0.021926222,
-0.007237131,
0.00876109,
0.037622336,
-0.0129167335,
0.013218841,
-0.012258813,
-0.00537414,
0.023134649,
-0.024759311,
-0.00643487,
-0.6285965,
-0.043718178,
0.012440077,
-0.006340881,
0.0034289095,
0.024625042,
0.0052633677,
0.007049153,
0.018905157,
0.029861556,
0.009781539,
0.018945439,
-0.0024890224,
-0.021375718,
-0.013675357,
0.004175784,
-0.00007374337,
-0.01244679,
-0.0024537765,
-0.029861556,
-0.003907245,
0.03730009,
-0.02921706,
0.0017387911,
-0.00082953426,
0.039931774,
0.03010324,
-0.021550268,
-0.0052902214,
0.0048504886,
-0.034453575,
0.03045234,
-0.017844427,
0.0022657993,
0.051962327,
-0.017710159,
-0.02159055,
0.01642117,
0.010419319,
0.039126158,
-0.03826683,
-0.016944822,
0.027954927,
-0.014232576,
-0.009680837,
0.034748968,
0.016542012,
0.005488269,
0.0068511055,
-0.0026249704,
0.009331736,
0.007310979,
0.0033802367,
-0.009063197,
0.0069551645,
-0.02612886,
0.015951227,
-0.023336053,
0.013776059,
-0.009116905,
0.0022020212,
-0.01028505,
-0.004665868,
-0.037649192,
-0.020596955,
0.01194328,
-0.006421443,
-0.014353419,
0.0119701335,
-0.02803549,
0.018300945,
0.0141654415,
-0.005595685,
0.005048536,
0.035688855,
0.022047065,
0.0155349905,
-0.012567633,
-0.012520638,
0.008150164,
0.008975922,
-0.009546568,
-0.043476492,
-0.000010588154,
0.018529203,
-0.008445557,
-0.0023144719,
0.0010926188,
-0.009123618,
-0.0146890925,
0.0015348692,
0.024020828,
-0.004783354,
-0.04277829,
0.0006209968,
0.015078474,
0.00581723,
-0.005390924,
0.027377568,
-0.00040050098,
-0.014313138,
-0.019442236,
-0.005766879,
-0.019227404,
0.010144067,
0.009909095,
-0.0006562426,
0.022154482,
0.04366447,
-0.037944585,
-0.0036185654,
-0.010714713,
-0.012762324,
0.0041590002,
0.043100536,
-0.022409594,
-0.019267686,
-0.00078337913,
-0.009781539,
-0.035957396,
0.015561845,
0.018784314,
-0.015239598,
0.011533758,
-0.008036034,
0.00031406494,
0.010694573,
-0.013574655,
0.0151053285,
-0.021201167,
0.006535572,
-0.014890497,
0.02900223,
-0.01717308,
0.030747734,
0.02149656,
0.028894814,
-0.0035984248,
-0.026169142,
-0.015722968,
-0.02728358,
-0.004316767,
0.0023362907,
0.013708925,
0.008096456,
-0.022490155,
0.018260663,
-0.00036336706,
-0.007545951,
0.007646653,
-0.0074721025,
0.0033936638,
0.0027978425,
-0.0015130504,
-0.00042378838,
-0.034238745,
0.009593562,
-0.041704133,
-0.0011673062,
-0.010620724,
0.023873132,
0.021416,
-0.0014971058,
0.0017186507,
-0.02008673,
-0.009815106,
0.014071452,
-0.011184656,
0.023389762,
-0.02975414,
-0.02180538,
-0.026612232,
0.010580443,
0.015441002,
0.01381634,
0.010969825,
-0.010580443,
-0.018905157,
-0.005337216,
0.018032406,
0.004598733,
0.001488714,
0.00009613912,
0.017065665,
0.019603359,
-0.0016036823,
0.0092511745,
-0.013252408,
-0.0012537423,
0.03488324,
-0.005931359,
-0.0011782156,
-0.0098822415,
0.025323244,
-0.008338141,
-0.013614936,
-0.009110191,
0.0034641554,
-0.044684917,
0.040280875,
0.02851886,
-0.02101319,
0.016098924,
-0.018045831,
0.010177635,
-0.00800918,
0.005541977,
-0.02163083,
0.020341842,
-0.0052767945,
0.002196986,
-0.0031939377,
-0.014447407,
-0.0075526643,
0.0005416939,
0.000039861283,
-0.0045718793,
-0.010318617,
-0.028330883,
-0.002881761,
-0.008331427,
-0.028223466,
0.025846895,
0.003920672,
0.0040146606,
0.022396166,
-0.0112450775,
-0.0029069365,
-0.0046289437,
-0.03311088,
-0.0026350406,
0.01638089,
0.00024902812,
0.013467239,
0.0017060629,
0.027444704,
0.020986335,
-0.00904977,
0.027578972,
0.009774826,
0.014420553,
0.01549471,
0.02379257,
0.022503583,
0.013527661,
0.009600275,
0.023470324,
0.029458746,
-0.011231651,
0.0065422854,
0.004642371,
0.005877651,
-0.013252408,
-0.015011339,
0.016394315,
-0.0051123146,
0.0008337302,
0.013185273,
0.014004318,
0.028948523,
0.0045819497,
-0.008646961,
0.009385444,
-0.01286974,
-0.0008719131,
-0.007438535,
0.022637852,
-0.01425943,
-0.0055856146,
-0.0016036823,
-0.042724583,
-0.0019771196,
0.025417233,
0.0038602506,
0.0065792096,
0.0021483134,
-0.016877687,
0.014353419,
0.026155716,
0.004665868,
0.00015325614,
-0.034185037,
0.035876833,
0.013883475,
-0.005787019,
-0.025981164,
0.0057803057,
0.0035514305,
-0.0004623909,
0.0032006511,
0.0018478852,
-0.0003277017,
0.00062938867,
0.010211202,
0.00087359146,
-0.026813636,
0.024933862,
-0.014621958,
-0.0141654415,
-0.008116596,
0.005612469,
-0.005451345,
-0.035205483,
-0.014769654,
0.014366846,
-0.00033986988,
-0.031043127,
-0.021416,
-0.020811785,
0.012299094,
0.010258196,
0.002019079,
-0.0008228208,
-0.011647887,
0.00044728557,
0.01491735,
-0.008391849,
-0.006689982,
0.0012210141,
-0.010567016,
-0.011278645,
-0.031231105,
0.011822437,
-0.018556057,
0.03998548,
0.016233193,
0.008908787,
0.02838459,
0.019039428,
-0.0025091628,
-0.0026988187,
-0.009224321,
0.0062166816,
-0.013393391,
0.012124543,
-0.01256092,
0.009895668,
-0.0072639845,
0.004702792,
0.027444704,
-0.00042861368,
-0.0011236686,
-0.0016766915,
0.0021130675,
-0.0014576642,
0.013158419,
0.038857616,
0.01399089,
0.017226787,
-0.027578972,
0.025094986,
0.023013806,
-0.0031066625,
0.0069685914,
-0.008955781,
0.005750095,
-0.014058026,
0.03367481,
-0.01198356,
-0.011795583,
0.019576505,
-0.0059749964,
0.011862718,
0.027740097,
0.040979076,
0.019831618,
-0.0016137526,
-0.002050968,
0.0024453849,
-0.0026618945,
0.001334304,
0.02193965,
-0.005531907,
-0.045141432,
0.043234807,
0.013091285,
-0.019066282,
-0.01562898,
0.018730607,
0.007310979,
0.0053271456,
0.007156569,
0.013138278,
0.0001281855,
-0.0049344073,
-0.028357737,
-0.019885326,
0.0018663473,
-0.03372852,
-0.008875219,
-0.034990653,
0.020127011,
-0.010097072,
-0.014098306,
0.011157802,
-0.0135410875,
-0.029995825,
0.012299094,
0.0039508827,
0.023685155,
0.014286283,
-0.03378223,
0.030183803,
0.019455662,
-0.00902963,
0.0062334654,
0.0068746028,
-0.020758078,
0.035151776,
-0.0024118174,
0.0015734717,
-0.027028468,
-0.0325738,
0.023591166,
0.0028280532,
0.012151398,
-0.0141654415,
0.026719647,
-0.005182806,
0.011473336,
0.0017673234,
0.020892348,
-0.014017745,
-0.056876596,
-0.01242665,
-0.021402571,
0.0050552497,
-0.02961987,
-0.012064122,
-0.01682398,
-0.016515158,
-0.00079680607,
0.010365612,
-0.01761617,
0.014944205,
0.0057534515,
0.011688167,
0.006243536,
0.027525265,
0.04546368,
-0.012554206,
0.023362909,
0.019871898,
-0.024383357,
0.016636001,
0.021228021,
0.017159652,
0.018193528,
-0.01734763,
0.011882858,
0.01136592,
-0.01646145,
-0.020690942,
0.009385444,
-0.009036343,
0.036011104,
0.019683922,
-0.02988841,
-0.02238274,
-0.012990582,
-0.0055486904,
0.0018797742,
-0.011043673,
-0.033486836,
0.008593254,
-0.028572567,
-0.019791337,
-0.017602742,
0.04071054,
-0.037273236,
0.0036588463,
0.008989349,
-0.0063240975,
0.023430042,
-0.027498411,
0.0006100874,
-0.027444704,
-0.00014045858,
-0.01337325,
-0.020596955,
0.010654291,
0.0012906664,
0.031419083,
-0.018864876,
0.034265596,
-0.013131565,
-0.0014761263,
0.006847749,
0.0034708688,
0.01198356,
0.0012646517,
0.013675357,
-0.012245386,
0.008781231,
-0.0053976374,
0.010204488,
0.00314023,
-0.0011547185,
0.025229255,
0.009022916,
-0.018891731,
-0.035312902,
-0.014890497,
-0.011627746,
-0.024302796,
0.015696114,
-0.0004002912,
0.0011127592,
-0.0318756,
0.0008169465,
0.010936257,
0.0147428,
0.0013259122,
-0.003917315,
0.008653674,
-0.016622575,
-0.007310979,
-0.0052096597,
0.030183803,
-0.00076449744,
-0.0030613465,
0.007888338,
-0.035688855,
-0.00043679573,
0.0014333278,
0.012278954,
0.007169996,
0.0010850661,
-0.007243844,
0.011560611,
0.0055117663,
-0.020059876,
-0.005595685,
-0.03611852,
-0.017763866,
0.0056561064,
0.0015373868,
-0.029458746,
0.0077943495,
-0.008787944,
-0.011896285,
0.023322627,
-0.01624662,
-0.0011832507,
-0.012225246,
-0.009291455,
-0.00028595226,
-0.023591166,
0.029512454,
-0.0006285495,
-0.01885145,
-0.035312902,
-0.019482516,
-0.0017169723,
-0.013138278,
0.020556673,
0.03668245,
0.0013485701,
-0.012500498,
0.01348738,
0.018703753,
-0.013896902,
-0.037998293,
0.014178868,
0.019254258,
-0.019858472,
-0.011117522,
-0.027484983,
-0.001779072,
0.017199934,
0.00051232235,
0.0037226242,
-0.0014954275,
-0.030559758,
0.01505162,
0.014756227,
-0.03160706,
0.02657195,
0.027041893,
0.019160269,
0.00968755,
-0.008076316,
-0.029673578,
0.0081031695,
-0.03434616,
0.02776695,
0.016917968,
0.017280495,
0.0151053285,
-0.008996062,
-0.0115538975,
0.012003701,
-0.026303412,
0.034856383,
0.020019595,
-0.0022641208,
0.012842886,
0.008908787,
-0.010493168,
-0.034936946,
-0.010479741,
-0.003390307,
-0.029995825,
-0.002309437,
0.017951844,
-0.0014635385,
0.0030428844,
-0.00460209,
-0.020422405,
0.011748589,
0.0038333966,
-0.030882005,
0.0014820006,
-0.02193965,
-0.008465697,
-0.0023228638,
0.0005119028,
-0.0038736775,
-0.008680529,
-0.016474878,
0.0025746194,
-0.007606372,
-0.002428601,
0.025806613,
0.01275561,
0.002695462,
-0.021093752,
-0.00051567913,
-0.021375718,
-0.037971437,
0.0085261185,
-0.006871246,
-0.03990492,
0.011621033,
-0.028357737,
0.019106561,
-0.013648503,
-0.02776695,
0.0049310504,
0.02427594,
-0.008062889,
-0.016676283,
-0.020489538,
0.01717308,
-0.008559686,
-0.018287517,
0.0325738,
-0.023080941,
-0.014286283,
-0.0043872586,
0.02406111,
0.00613612,
-0.049276937,
0.012983869,
-0.02886796,
0.021268303,
-0.0069685914,
-0.020288134,
0.013037576,
-0.01744162,
-0.022181336,
0.009909095,
-0.003893818,
-0.018220382,
-0.008727523,
-0.018502349,
-0.013708925,
0.006377805,
-0.020247852,
-0.021738246,
0.005236514,
-0.03050605,
-0.024880154,
0.008465697,
-0.02035527,
0.04997514,
0.0062871734,
-0.008539545,
0.0034910091,
-0.0074519617,
-0.034534138,
0.0349638,
-0.008707383,
0.016434597,
0.013500807,
0.0035950681,
0.0023732148,
0.019160269,
-0.006364378,
0.030613465,
-0.0063912324,
0.008096456,
0.008982635,
0.0065053613,
0.060313895,
-0.03311088,
-0.04119391,
0.0034507283,
0.017777292,
0.021335436,
-0.008324714,
0.029109646,
-0.0074049677,
-0.010318617,
-0.028142905,
-0.01518589,
0.007666793,
0.013218841,
0.009781539,
-0.029593017,
-0.008438843,
0.006723549,
0.011446482,
-0.013547801,
-0.014514542,
0.0061965412,
-0.000024349474,
0.019670494,
-0.021603975,
-0.01395061,
0.016327182,
-0.023698581,
-0.011359206,
0.011547185,
0.006861176,
-0.005938072,
0.013870048,
-0.009553281,
0.0067101223,
-0.0020576813,
-0.016058642,
-0.0057735923,
0.0028196613,
0.0016456416,
-0.033164587,
0.0048034946,
0.011567324,
-0.011386061,
-0.014957632,
0.0012008736,
-0.006213325,
-0.013923756,
0.026759928,
0.0039508827,
-0.004112006,
-0.015091902,
-0.0030529546,
0.0051895194,
-0.007693647,
-0.021429425,
0.01933482,
-0.011251791,
0.0050888173,
-0.005273438,
-0.021563696,
0.012943588,
-0.015279879,
0.0008169465,
-0.0038837476,
-0.0046625114,
0.17562461,
0.0035245765,
0.0048404187,
0.005400994,
-0.03133852,
-0.0022641208,
0.032466386,
-0.004722933,
-0.018045831,
0.0074519617,
0.013306116,
-0.00017486516,
-0.0007091112,
0.0016531942,
0.018206956,
-0.0029606444,
-0.022704987,
-0.031016273,
-0.016837405,
-0.02388656,
-0.017374484,
-0.016260047,
0.012198391,
0.0130174365,
0.02334948,
-0.0009549924,
-0.010097072,
0.036548182,
0.017737012,
0.006820895,
0.0026568593,
-0.008183731,
-0.0065959934,
-0.0038871046,
-0.0061831144,
-0.022275323,
0.011896285,
-0.023752289,
-0.016488304,
-0.007955473,
-0.004038158,
0.031419083,
-0.011224938,
-0.005578901,
-0.010701286,
0.042939413,
0.0026266486,
-0.037219528,
-0.032144137,
0.008022607,
-0.024383357,
0.0042597027,
0.0007615603,
-0.024557907,
0.016300328,
0.000039494138,
0.032681216,
-0.011835864,
-0.0046826517,
0.023054088,
0.013608222,
0.00690817,
-0.009439152,
0.014756227,
0.0071431417,
0.054620866,
-0.0043637613,
0.0063509513,
0.008197158,
0.0046591545,
0.009090051,
0.00091219397,
-0.038884472,
0.028841106,
0.0026887485,
-0.013856621,
0.015978081,
0.0037662617,
0.0019099849,
-0.0011421307,
-0.004652441,
-0.0046255873,
-0.018784314,
0.00690817,
-0.009627129,
-0.041516155,
0.014474262,
0.008378422,
-0.01460853,
0.014339992,
0.0103991795,
0.028142905,
-0.012701903,
-0.0020643948,
0.01132564,
-0.003997877,
0.0015054977,
0.008714096,
0.018864876,
-0.0018159961,
-0.026464535,
0.07067951,
0.010989966,
-0.008566399,
-0.016058642,
-0.0068511055,
-0.0045718793,
0.035205483,
-0.009788252,
-0.01920055,
0.018650046,
0.0023144719,
-0.010426033,
-0.017052237,
0.00023539136,
0.0058440836,
-0.0038199697,
-0.0016808873,
0.016877687,
-0.0042227786,
0.018502349,
-0.038911324,
-0.0010363933,
0.031902455,
-0.017589316,
-0.020919202,
-0.03367481,
0.017213361,
-0.011171229,
-0.021697965,
-0.0053640697,
-0.022369312,
0.0106140105,
0.010358898,
-0.008821512,
0.0035950681,
0.027740097,
-0.0046088034,
-0.012312521,
0.024799593,
-0.020328416,
0.011104095,
0.0186769,
0.009419011,
-0.028679984,
-0.022530437,
0.03386279,
0.00997623,
-0.003934099,
-0.01734763,
-0.0049310504,
-0.03748807,
0.014017745,
-0.015065047,
0.023738863,
-0.017132798,
-0.017213361,
-0.04202638,
-0.0017740369,
0.002609865,
-0.03633335,
-0.004618874,
0.016891114,
-0.013077858,
-0.0019351604,
-0.0068678893,
-0.16896485,
0.0057031005,
0.012896594,
0.0110369595,
0.04640357,
0.009868815,
0.02105347,
-0.0006679912,
-0.026491389,
0.00966741,
0.026115434,
0.0010397501,
-0.028921667,
-0.03359425,
-0.009325023,
-0.003363453,
-0.01995246,
0.033755373,
0.01871718,
0.012500498,
0.012225246,
-0.03324515,
0.0036319923,
-0.015441002,
0.006653058,
0.02489358,
-0.022329032,
0.027404422,
-0.0016288579,
-0.010808702,
-0.039367843,
0.0012587773,
0.026289985,
-0.009143759,
0.023685155,
-0.0057165273,
0.008150164,
0.02410139,
-0.00721699,
0.020852067,
0.0025158764,
0.03209043,
0.017589316,
-0.0055117663,
-0.015024766,
0.0049814014,
0.010499882,
-0.011285358,
0.012493785,
0.0030193874,
0.014595103,
0.0002830151,
-0.012775751,
0.00063820014,
-0.021979932,
-0.0069283107,
0.0089423545,
-0.0069148834,
0.010217915,
0.0005442114,
0.011909712,
-0.03646762,
0.016797125,
0.0015382259,
0.013883475,
-0.034614697,
-0.002155027,
0.015467856,
-0.009056483,
-0.0023027235,
-0.021603975,
0.003276178,
0.008479124,
-0.012534066,
0.033755373,
0.020328416,
-0.015172463,
0.014339992,
-0.0067705438,
0.015884092,
-0.0043637613,
-0.0032627508,
-0.042456042,
-0.0037024838,
0.0045181713,
0.023577739,
0.008646961,
0.018932011,
-0.004820278,
-0.00268707,
0.015400722,
-0.01911999,
-0.00781449,
-0.012023841,
0.004256346,
0.029082792,
0.021120606,
0.017898135,
0.00768022,
0.0042362055,
0.0024839872,
-0.015347013,
-0.028975377,
-0.00014496919,
0.03716582,
-0.020543246,
-0.015709542,
0.01013064,
0.06068985,
-0.01601836,
-0.0006629561,
0.02255729,
0.003944169,
0.009103478,
-0.0071431417,
0.011936566,
-0.008915501,
-0.0123863695,
-0.0076399394,
-0.01399089,
0.04339593,
-0.013212127,
-0.03619908,
0.016488304,
-0.017011955,
0.003145265,
-0.11976847,
-0.020664088,
-0.005354,
0.006827608,
-0.015454429,
0.015884092,
0.0001224161,
0.0022087346,
0.00043301942,
0.018838022,
-0.010963111,
-0.036548182,
-0.019026,
0.010137354,
0.02635712,
-0.0027172808,
0.011023533,
-0.014581677,
-0.019093135,
0.035688855,
0.00050812645,
0.006189828,
-0.0049545476,
-0.01317856,
-0.019495944,
-0.00064701156,
0.009170612,
-0.0012990582,
0.008398563,
0.006394589,
0.021509988,
-0.00039147976,
0.018260663,
0.0060790554,
-0.027686387,
0.009311596,
-0.023295773,
-0.03276178,
0.010808702,
-0.043825593,
-0.006810825,
-0.004142217,
0.014783082,
0.03166077,
0.012158111,
0.0037662617,
-0.020637235,
-0.0042227786,
0.011815723,
-0.018421788,
-0.0047330027,
-0.03995863,
-0.008358282,
-0.004152287,
0.040092897,
-0.018864876,
0.009244461,
0.011117522,
-0.010103786,
0.018180102,
0.015776675,
-0.0036252788,
-0.03010324,
0.027713243,
0.00074267865,
-0.014178868,
-0.0016364106,
-0.056232102,
-0.01690454,
-0.05470143,
-0.017656451,
-0.0047330027,
-0.016260047,
-0.003336599,
-0.050727047,
0.00080435874,
-0.005736668,
-0.021697965,
0.0029925334,
-0.0130174365,
-0.027068747,
-0.017320776,
0.018918585,
-0.0011186334,
0.027498411,
0.03579627,
0.011715021,
-0.02798178,
0.002500771,
0.00149291,
0.023846278,
0.018018978,
-0.0010909403,
-0.020422405,
-0.03491009,
0.003920672,
-0.007760782,
-0.017401338,
0.019898752,
0.03147279,
-0.0037461214,
-0.008183731,
-0.056124687,
0.022610998,
-0.0012730435,
-0.020341842,
-0.0066664848,
-0.015414149,
0.0020828568,
0.023161503,
0.004048228,
0.031043127,
-0.055157945,
0.018878303,
-0.024208806,
0.020852067,
-0.03641391,
-0.007733928,
0.0315265,
0.008646961,
0.025041277,
0.012742183,
0.005092174,
-0.004192568,
0.009888954,
0.019536225,
-0.018556057,
-0.0025393735,
0.023228638,
0.0076735066,
0.013413532,
-0.005427848,
0.018180102,
-0.026477963,
0.021402571,
-0.001706902,
-0.04108649,
-0.02427594,
0.015065047,
0.007874911,
0.008848365,
0.028921667,
-0.0037931157,
-0.008828226,
0.009700977,
-0.02900223,
-0.026867343,
0.010224629,
-0.035420317,
0.015454429,
-0.008291147,
-0.0031553353,
0.024625042,
-0.0039005314,
-0.0028599421,
-0.024625042,
-0.017924989,
0.020489538,
0.004420826,
0.011641173,
-0.018609764,
-0.0038837476,
0.016058642,
-0.010848982,
-0.0013259122,
0.0149039235,
0.028679984,
-0.010929544,
-0.004175784,
0.026048299,
0.012030555,
-0.038025144,
-0.03085515,
-0.013467239,
0.0040650116,
-0.003353383,
-0.0003457442,
-0.0019586575,
0.01300401,
0.03023751,
-0.021375718,
0.024531053,
0.023832852,
0.0064550103,
-0.015306733,
0.020180719,
0.019751055,
0.0060891258,
0.017495327,
0.04154301,
-0.00920418,
-0.0037998292,
-0.031365376,
0.022543862,
0.023362909,
0.018999146,
0.014997913,
0.022463301,
0.018958865,
0.010989966,
0.016622575,
0.013131565,
0.010942971,
0.012728756,
0.016756844,
-0.017293923,
0.003177154,
-0.0051223845,
-0.030210657,
-0.019576505,
-0.03125796,
0.015333586,
-0.0033802367,
0.04038829,
0.0028632989,
-0.013279262,
-0.023255492,
-0.0028985445,
0.001792499,
0.005954856,
-0.009727831,
0.02790122,
-0.007928619,
0.024732457,
0.009318309,
-0.032251555,
0.026048299,
0.013534374,
0.019791337,
-0.020341842,
0.043583907,
-0.0056158253,
0.021456279,
0.004793424,
-0.037864022,
-0.02697476,
0.010640864,
-0.023295773,
0.01101682,
-0.017508755,
0.011352493,
0.07433164,
0.0046121604,
-0.0435302,
-0.0055352636,
-0.004655798,
-0.009036343,
-0.0052096597,
-0.014702519,
0.02608858,
-0.011708308,
0.02070437,
-0.013393391,
0.0012856312,
-0.0022523722,
-0.026988186,
-0.015615553,
0.020919202,
0.022100773,
0.000889536,
-0.005800446,
0.019536225,
-0.009063197,
0.026330266,
0.0046826517,
-0.02900223,
-0.010714713,
0.010936257,
0.0016750131,
0.001711098,
-0.03525919,
-0.0055386205,
0.0027021754,
-0.004635657,
-0.022476729,
0.0049948287,
0.00044602677,
-0.012856313,
-0.008210585,
-0.0017102588,
0.0064785075,
-0.009311596,
0.030935712,
-0.0236583,
-0.0054312046,
-0.009922522,
-0.011506903,
-0.0111376615,
-0.03072088,
-0.016367462
] |
Fumarase deficiency is a rare autosomal recessive inborn error of metabolism of the Krebs Tricarboxylic Acid cycle. A heavy neurological disease burden is imparted by fumarase deficiency, commonly manifesting as microcephaly, dystonia, global developmental delay, seizures, and lethality in the infantile period. Heterozygous carriers also carry an increased risk of developing hereditary leiomyomatosis and renal cell carcinoma. We describe a non-consanguineous family in whom a dichorionic diamniotic twin pregnancy resulted in twin boys with fumarase deficiency proven at the biochemical, enzym | [
-0.0079286685,
0.00013534668,
0.011282849,
-0.044011112,
-0.035502296,
0.024312805,
-0.031661328,
0.007942005,
-0.016950946,
0.002393938,
-0.0010769386,
-0.0016737559,
0.024992978,
0.009575752,
-0.0071284664,
-0.0048012123,
0.03400859,
-0.0062082345,
0.0012394796,
-0.008502147,
-0.0048445566,
0.0080286935,
-0.028033745,
-0.012476483,
-0.0031374588,
0.030461024,
0.01952493,
-0.025606466,
-0.02097863,
-0.025459763,
0.010242586,
-0.009128972,
0.023979388,
-0.02583319,
0.013116646,
-0.0013511745,
-0.0028590553,
-0.0046545085,
0.0077419546,
-0.025019651,
0.01301662,
0.016230766,
-0.008335438,
0.027660318,
-0.012643192,
-0.0031191208,
0.006605001,
-0.023392573,
-0.015257185,
-0.008642182,
0.009882496,
0.02093862,
-0.012403131,
-0.0013536752,
-0.013463399,
0.0047245263,
-0.01799121,
-0.02509967,
-0.011629603,
-0.0055147256,
-0.002205557,
0.00440778,
-0.02619328,
0.0076352614,
0.0036875978,
0.016164081,
0.00048303863,
0.020911947,
-0.016830916,
0.013330032,
0.014830411,
0.0026923465,
-0.0042510736,
-0.00426441,
0.030994494,
-0.008888911,
-0.021071987,
-0.018538015,
-0.01423026,
-0.0028823945,
0.021405404,
-0.013856832,
-0.036035765,
0.016310785,
0.017150998,
0.0084087895,
0.00828876,
0.014363627,
0.01685759,
-0.012323111,
0.012689871,
0.03176802,
-0.0071884817,
0.001902147,
-0.013923516,
0.0051046223,
0.0038142963,
0.016910937,
-0.00084271276,
-0.010756049,
-0.0005384693,
0.010689366,
-0.022045566,
-0.009249002,
-0.014563677,
0.010409295,
-0.012416469,
0.0071884817,
0.0002565231,
-0.026873453,
0.011516241,
0.04651841,
-0.0033625157,
-0.019298207,
0.004374438,
-0.0036609243,
0.036809295,
0.0020488508,
-0.0026656731,
-0.019231522,
0.009989189,
0.008395453,
-0.00020505178,
-0.02037848,
0.01932488,
0.0010210911,
-0.027980398,
-0.0028590553,
-0.022565698,
-0.020965293,
0.022232281,
0.010656024,
0.045424804,
0.0020821923,
-0.0066450112,
0.02227229,
-0.024926294,
-0.022499014,
-0.02105865,
-0.03366183,
0.013550088,
0.017897852,
-0.050252687,
0.005801465,
-0.010936094,
0.019098155,
0.02489962,
0.02004506,
0.00978247,
-0.0108360695,
0.029260721,
-0.027580297,
0.001998838,
-0.026179943,
0.030727759,
0.023992725,
0.003787623,
0.012483152,
-0.011189492,
-0.010702702,
-0.003824299,
-0.019631624,
-0.017297702,
0.011262844,
-0.005498055,
0.0244195,
0.020485172,
-0.0007118464,
0.006778378,
-0.029180702,
0.00027277722,
0.025379742,
-0.016070725,
0.022965798,
-0.018711392,
0.011242839,
-0.00063099264,
0.013910179,
-0.02579318,
-0.05137297,
-0.00933569,
0.055107247,
0.028353825,
-0.008308765,
-0.013710128,
0.013396716,
0.017817833,
0.014963779,
0.012963274,
-0.010342612,
-0.017524425,
0.0023489264,
0.008062036,
-0.022098914,
-0.6324797,
-0.01289659,
-0.02631331,
-0.010555998,
-0.01103612,
0.031394593,
0.016257439,
0.00444779,
0.006414953,
-0.0077352864,
-0.015897347,
0.0039309924,
0.02332589,
-0.016604193,
-0.0072551654,
-0.01815125,
-0.018297954,
-0.02093862,
0.016470825,
-0.0012811568,
-0.010749381,
0.026046576,
-0.029020661,
-0.011102803,
0.0035342257,
0.025659813,
0.02525971,
-0.028913967,
0.0148837585,
0.024366152,
-0.00487123,
0.011296186,
-0.016510835,
-0.0038176307,
0.05638757,
-0.007575246,
-0.01713766,
0.030834453,
0.0020121748,
0.027793685,
-0.008675524,
0.00860884,
0.04651841,
-0.01827128,
-0.014123566,
0.033821873,
0.01657752,
-0.012943268,
0.035875726,
-0.010489315,
0.0037209396,
-0.008882243,
0.0074418793,
0.008342107,
0.015083808,
-0.0006022354,
0.014096892,
-0.013356706,
0.013556756,
0.010362617,
-0.0063482695,
0.04054357,
0.0017204344,
-0.0112161655,
-0.021938873,
-0.0031007829,
-0.009682445,
0.0056680976,
-0.0055580703,
-0.006661682,
0.012836575,
0.013830159,
-0.0007989517,
0.01552392,
0.010936094,
0.023472594,
0.008355443,
0.008342107,
-0.015203839,
0.015550593,
0.013750139,
0.0063449354,
-0.043477643,
-0.009128972,
0.028353825,
-0.0072551654,
-0.03366183,
0.007175145,
-0.018911442,
0.015617277,
0.021925537,
-0.00942238,
-0.0024806263,
-0.023285879,
-0.009495731,
0.006815054,
-0.008835564,
0.017391058,
-0.0019671633,
0.0014178581,
-0.010589341,
-0.014296943,
-0.011476231,
-0.009442384,
0.016470825,
0.028273806,
-0.04595827,
-0.023032483,
0.03427532,
-0.020511845,
-0.008102045,
-0.021965547,
0.0041977265,
-0.012183076,
-0.0015995705,
-0.026420005,
-0.01103612,
-0.01819126,
-0.013396716,
-0.01709765,
-0.010335943,
0.0013845162,
-0.0069350842,
0.0057447837,
-0.006638343,
0.008695529,
0.008382116,
-0.020511845,
0.0074885576,
-0.015670624,
0.002282243,
-0.0015887344,
0.021218691,
-0.010442637,
0.016990958,
-0.026793431,
0.02846052,
0.0040243496,
-0.002018843,
-0.022058902,
-0.0074085374,
-0.005388027,
-0.004891235,
0.03598242,
-0.0015570598,
-0.017711138,
0.0024806263,
-0.0066116694,
-0.008848901,
0.00517464,
-0.022552362,
0.005084617,
-0.014803738,
0.03683597,
0.01673756,
-0.010209245,
-0.025593128,
-0.017764486,
0.01403021,
-0.009102298,
0.027446931,
0.0013453397,
0.005844809,
0.0039043191,
-0.02947411,
-0.007868653,
0.017577771,
-0.0075885826,
0.005351351,
-0.023659308,
-0.035022177,
-0.0062349075,
0.007135135,
-0.0010060874,
0.015297196,
0.035075523,
0.011402879,
-0.008668856,
-0.003690932,
-0.0008827229,
0.006221571,
0.003480879,
-0.016804243,
-0.007962011,
0.023059156,
0.011943015,
0.033981916,
-0.0042244,
0.012656529,
0.03982339,
-0.0006855898,
0.019511594,
0.016550846,
0.006825057,
0.017751148,
-0.002322253,
0.02069856,
-0.0073685274,
-0.021685475,
0.04345097,
-0.0005984845,
-0.03723607,
0.033181712,
-0.0066083353,
0.027660318,
-0.02752695,
0.017471079,
0.000913564,
0.018911442,
-0.0005384693,
-0.0048245518,
0.017150998,
0.00056847685,
-0.00014368212,
-0.003860975,
0.019378226,
-0.005017934,
-0.013310027,
-0.0025706491,
-0.014977115,
0.009309017,
-0.020565193,
0.023872694,
0.014617024,
0.02567315,
0.023299217,
-0.022752412,
0.021485426,
0.017871179,
0.0032224804,
0.0064582974,
0.014590351,
-0.0009894165,
0.0034308664,
-0.009282344,
0.026099924,
0.0012228087,
-0.016817579,
0.037129376,
0.005578075,
-0.0020455164,
0.0016312452,
0.012969942,
0.01721768,
0.016097398,
-0.012469815,
0.030967819,
0.00023172518,
-0.00088939123,
0.012016367,
-0.008122051,
0.02720687,
-0.0070884563,
-0.0067083607,
0.0042677443,
-0.00958242,
-0.0022405658,
0.023539277,
0.03294165,
0.017804496,
0.006334933,
-0.005468047,
0.0030924475,
-0.0148837585,
-0.016457489,
0.0027540287,
-0.0055480674,
-0.017297702,
0.013750139,
-0.019871684,
-0.014496994,
0.0040576914,
-0.024512855,
-0.019138165,
0.023899367,
0.0056781005,
0.010502652,
0.009849153,
0.024486182,
0.022819094,
0.006241576,
-0.031181207,
0.05644092,
0.011209497,
-0.014723718,
-0.016910937,
-0.011943015,
0.0019204849,
0.013910179,
0.017764486,
-0.0017004294,
-0.005021268,
0.010402626,
0.014950441,
-0.022765748,
-0.0008735539,
0.029554129,
-0.013470068,
0.025379742,
-0.011129477,
-0.011642939,
-0.00624491,
-0.020205101,
0.0148570845,
0.046438392,
0.025379742,
-0.022085577,
0.0116962865,
0.010162566,
-0.0080553675,
0.010622682,
-0.017804496,
-0.013323364,
-0.002488962,
-0.01641748,
-0.019738317,
-0.0015545592,
0.004907906,
0.033315077,
-0.027633645,
0.0042877495,
-0.025019651,
0.00547805,
-0.004257742,
0.01358343,
0.03371518,
-0.03246153,
-0.0027840363,
0.021298712,
0.012383127,
-0.0005313842,
-0.025593128,
0.018297954,
-0.008342107,
-0.0042310683,
-0.021618793,
0.018791411,
0.021192018,
0.01435029,
0.020605203,
-0.0040143467,
-0.022178933,
-0.011542914,
0.018818084,
-0.005251326,
-0.009155645,
0.02199222,
0.027473604,
0.0138968425,
0.019218186,
0.00483122,
0.026206616,
0.007555241,
0.0072951755,
-0.008468805,
-0.004637838,
-0.0009494064,
0.03222147,
0.010689366,
-0.019231522,
0.0017287699,
-0.0041210405,
-0.008222076,
0.030861126,
0.022178933,
0.007268502,
0.016350795,
0.0050012628,
0.026980145,
-0.009128972,
-0.034888808,
0.007942005,
0.0308878,
-0.013556756,
0.039636675,
-0.008908916,
-0.0039676684,
-0.0043877745,
0.024499519,
-0.015990704,
0.015097145,
-0.018364636,
-0.0025523112,
-0.0026790097,
0.003500884,
-0.015163829,
-0.011622935,
0.01228977,
0.0045211418,
0.012376458,
-0.015083808,
-0.013976863,
-0.016390806,
-0.027980398,
0.016190754,
-0.0103559485,
-0.030941145,
0.000011578444,
0.026593382,
0.011016115,
-0.0063616065,
-0.02477959,
0.017044304,
0.01103612,
-0.028887294,
-0.034488708,
-0.014897095,
-0.004531144,
0.024192775,
-0.0042143976,
0.012549835,
-0.021818843,
-0.03230149,
0.016750896,
0.021592118,
-0.020338468,
0.0038509723,
0.003424198,
-0.01604405,
-0.0037342762,
0.021725485,
0.024166102,
-0.016337458,
-0.024726244,
0.0023522605,
-0.023512604,
-0.015150492,
-0.030727759,
-0.035475623,
-0.03440869,
-0.003884314,
0.004697853,
-0.00089689315,
-0.01916484,
0.01244981,
0.0039676684,
0.005004597,
0.004281081,
0.029980903,
0.018377975,
-0.022298964,
0.019951705,
-0.012083051,
-0.015323869,
0.031714674,
-0.00723516,
0.034675423,
0.023499267,
-0.005938166,
0.003580904,
0.014096892,
-0.04611831,
-0.0004863728,
0.036489215,
0.010816065,
0.034622077,
-0.0027456933,
-0.031821366,
-0.027340237,
-0.022565698,
-0.0072018183,
0.0067983833,
-0.002700682,
-0.00032820788,
-0.020485172,
0.010729376,
-0.017004294,
-0.028807273,
0.0123031065,
-0.032594897,
0.0064182873,
-0.014603687,
-0.020165091,
0.0015737307,
-0.030300984,
0.012309775,
-0.036062438,
-0.03371518,
-0.012929931,
-0.025966557,
0.018377975,
-0.011662945,
0.014657035,
0.019778328,
0.023472594,
-0.00036113284,
0.014096892,
-0.009875827,
-0.0018721394,
0.010976105,
0.022405658,
0.008148724,
-0.010909421,
0.018884769,
0.024446173,
0.010636019,
0.017817833,
-0.030007577,
0.035315584,
0.030274311,
-0.016484162,
-0.008555493,
0.018084567,
-0.022939125,
-0.0109561,
0.029340742,
-0.006474968,
0.005991513,
-0.0333951,
-0.005057944,
0.027873704,
0.00044011112,
-0.00958242,
-0.001657085,
0.017857842,
-0.024432836,
0.021418741,
-0.01669755,
0.020178428,
0.0021438748,
-0.03051437,
0.017724475,
-0.013803486,
-0.010375953,
0.0027356907,
0.016764233,
-0.0038509723,
-0.022645717,
0.008102045,
0.014430311,
0.026526699,
0.0025623136,
0.008615509,
-0.013576762,
-0.02211225,
-0.005494721,
0.02931407,
-0.03427532,
0.010882748,
0.0012803233,
-0.010929426,
0.023605961,
-0.018658044,
-0.015617277,
-0.008862237,
-0.014416974,
0.019258196,
-0.015043799,
0.032034755,
0.001958828,
-0.006661682,
-0.03675595,
-0.006828391,
0.035502296,
-0.0022105582,
0.040810306,
0.02505966,
0.018217932,
-0.0055680727,
0.0075218994,
-0.016297448,
-0.03795625,
-0.03144794,
0.007308512,
0.0032658246,
0.009115635,
-0.015417227,
0.009569082,
-0.006605001,
0.020191764,
-0.039343268,
0.020471836,
-0.027446931,
-0.02752695,
-0.02179217,
0.019818338,
-0.010982773,
0.0067617074,
0.022539025,
0.017150998,
-0.0063616065,
-0.031421266,
-0.011509573,
0.015750643,
0.0027757008,
0.035342257,
0.00016889682,
0.00055805757,
-0.012616519,
0.01002253,
-0.03480879,
-0.00982248,
-0.017204344,
0.034542054,
-0.0056680976,
-0.0026023237,
0.010802728,
0.0069350842,
0.0024439504,
0.007455216,
0.005554736,
-0.039076533,
-0.036355846,
0.0043811062,
0.024179438,
0.0055880775,
0.0028357161,
0.006848396,
-0.013470068,
-0.018391311,
-0.012669866,
-0.034568727,
0.0095224045,
-0.03646254,
-0.01791119,
-0.011869663,
0.020605203,
0.021538772,
-0.0014737054,
-0.0121764075,
-0.012889922,
0.024019398,
-0.008182066,
0.016457489,
-0.009182318,
0.009148977,
0.0011686285,
0.006901743,
-0.008735539,
-0.028833948,
0.008542157,
-0.015563929,
-0.028833948,
-0.0223123,
-0.010576004,
0.0066083353,
0.009655772,
-0.022085577,
0.004474463,
-0.007668603,
0.014843748,
-0.007608588,
-0.016457489,
0.032968324,
-0.012516494,
0.02575317,
0.0016195757,
-0.01403021,
-0.023179187,
0.0002923655,
-0.019258196,
-0.008888911,
-0.008022025,
-0.013470068,
-0.018164586,
0.0023622632,
-0.0016345794,
0.012523162,
-0.006681687,
-0.022445668,
-0.019911695,
0.017084314,
0.012843243,
-0.0014545339,
-0.014563677,
-0.008642182,
-0.02477959,
0.008862237,
-0.017711138,
-0.011229502,
0.023552613,
0.0037176053,
-0.024392826,
0.0015353877,
-0.016924273,
0.04782541,
0.013603435,
0.0015178833,
-0.011576257,
-0.0019088153,
-0.028673908,
-0.0002596489,
-0.018724728,
0.003500884,
0.01220975,
0.00860884,
0.0059715076,
0.0148837585,
-0.020338468,
0.011869663,
-0.03726274,
-0.007815307,
0.0040977015,
-0.013883506,
0.02267239,
-0.025566455,
-0.014123566,
-0.0050279363,
0.003670927,
0.013843495,
-0.019151503,
0.013129982,
-0.014323616,
0.008402121,
-0.0030224298,
-0.0056714322,
0.0076219244,
0.016964283,
0.012196413,
-0.0027240212,
-0.010422632,
-0.020445162,
0.010789391,
-0.010495984,
0.0044277846,
0.006168224,
0.01916484,
0.010616014,
0.00091606466,
-0.0092423335,
0.004851225,
-0.016057387,
0.012496489,
0.023579286,
-0.0018738065,
0.0012336448,
0.013283354,
-0.02235231,
-0.0026990147,
-0.008788886,
-0.0029657488,
0.008308765,
-0.0061315484,
0.009842485,
-0.022218945,
-0.013976863,
-0.0029190704,
-0.020671885,
-0.0032574893,
-0.01018924,
-0.021858852,
-0.02461955,
0.04115706,
-0.0026289972,
-0.009829149,
-0.017564435,
0.0032658246,
-0.018244607,
0.01455034,
0.006368275,
0.038463045,
-0.017297702,
-0.009028946,
-0.012236423,
-0.027873704,
-0.004741197,
0.012089719,
-0.03787623,
-0.01232978,
0.013683455,
0.16377468,
-0.0017221015,
0.0026023237,
0.01807123,
-0.007455216,
0.009869158,
0.024446173,
-0.00016420813,
-0.016524171,
0.008808891,
0.022619044,
0.0019321545,
-0.009442384,
0.0022755745,
0.031181207,
0.0106093455,
-0.01988502,
-0.018137913,
-0.058894873,
-0.022872442,
0.0030391007,
-0.016590856,
0.005458045,
-0.0054713814,
0.034542054,
-0.009755797,
-0.005441374,
0.0048445566,
0.025339732,
0.0016020712,
-0.025313059,
0.006738368,
-0.01552392,
-0.011729629,
-0.0248196,
0.0013094973,
0.0029840868,
-0.015790654,
-0.005801465,
0.0141502395,
-0.009869158,
0.02583319,
-0.022245618,
0.0016979288,
-0.0417172,
0.023712654,
0.02069856,
-0.031554636,
-0.02822046,
-0.019151503,
-0.038036272,
-0.0036775952,
-0.0021572113,
0.026299974,
-0.019805001,
-0.010169234,
0.0118229855,
0.017524425,
-0.0066483454,
0.016817579,
-0.007308512,
0.017311038,
-0.016390806,
0.023712654,
-0.033581812,
0.019751653,
-0.022245618,
-0.018364636,
0.024632886,
-0.017551098,
-0.0046545085,
-0.04155716,
-0.018524677,
0.01018924,
0.008308765,
-0.007055115,
0.009115635,
-0.0019654962,
-0.010375953,
0.009569082,
0.0076619345,
-0.017444404,
-0.026913462,
0.0019838342,
-0.009455721,
-0.045211416,
0.011229502,
0.018057892,
-0.0078086383,
-0.03200808,
0.0071884817,
-0.0066916896,
-0.013223339,
0.0063916137,
-0.006981763,
0.0032641576,
0.006471634,
0.007535236,
0.0060581965,
0.0040510227,
-0.022765748,
0.06572326,
-0.011149482,
-0.0019855013,
0.0013611771,
0.012216418,
-0.0051412983,
0.021872189,
0.016630866,
0.0042043948,
-0.000012184066,
-0.014977115,
-0.012776559,
-0.016137408,
0.0052613285,
0.0068817376,
-0.0029274058,
-0.02113867,
0.021818843,
-0.018337963,
0.02320586,
-0.016150745,
-0.0015653953,
0.021925537,
-0.024192775,
-0.0015745643,
-0.037049353,
0.006411619,
-0.008188735,
-0.029394088,
0.0022939125,
-0.0059248293,
0.017777823,
-0.010696034,
0.005961505,
-0.014056883,
0.0007085122,
0.0000037183868,
-0.0019204849,
0.018377975,
-0.00096190954,
0.013516746,
0.016924273,
0.0049245767,
-0.038383026,
-0.020751907,
0.037449457,
0.0084488,
-0.015550593,
0.0029590805,
-0.030647738,
-0.0089756,
-0.009475726,
-0.010175902,
0.013790148,
-0.026753422,
-0.011709623,
-0.003674261,
0.0028707248,
-0.007121798,
-0.04649174,
0.02708684,
0.015030462,
-0.00072476635,
-0.0022355644,
0.0010419297,
-0.16782904,
0.0051079565,
-0.0056647635,
-0.016564183,
0.020351805,
0.0056247534,
0.031527963,
-0.0034542056,
-0.0023055822,
0.011056125,
0.033635158,
0.0038676432,
-0.020285122,
-0.007535236,
-0.0020205101,
-0.003199141,
-0.02947411,
0.02251235,
0.03315504,
-0.010202576,
0.039183225,
-0.020605203,
0.008402121,
-0.021125333,
0.009449053,
0.014950441,
0.009342359,
-0.017977873,
-0.015697297,
-0.0054080323,
-0.032488205,
-0.024752917,
0.03451538,
0.008122051,
0.016217427,
-0.0057747914,
-0.0036042435,
0.014977115,
-0.0057747914,
-0.0018604698,
-0.010589341,
0.040916998,
0.016990958,
-0.011329527,
-0.013210002,
0.01427027,
0.0031841374,
-0.0005101288,
0.008682192,
0.023939379,
0.015870674,
0.012643192,
0.010455973,
0.015163829,
0.01811124,
0.009969184,
0.0027606972,
0.0004301086,
-0.01988502,
-0.032061428,
-0.016684214,
-0.019618288,
0.008768881,
0.0047512,
0.017697802,
-0.030220965,
0.0031357917,
-0.015403889,
-0.015790654,
0.015950695,
-0.03011427,
-0.0050279363,
0.024086082,
-0.020458499,
0.020471836,
-0.0113428645,
-0.0036209142,
0.019084819,
-0.016350795,
-0.025779843,
-0.03640919,
0.028993988,
-0.027260216,
-0.009249002,
0.009795806,
0.04377105,
0.009102298,
0.0133367,
-0.008575499,
-0.005648093,
-0.008862237,
-0.021192018,
0.008655519,
-0.0036775952,
0.015497247,
0.02235231,
0.013109977,
0.0018054559,
-0.0076819398,
-0.021152008,
-0.012889922,
-0.011983026,
-0.044731293,
-0.012196413,
0.048892345,
0.0015937358,
-0.020311795,
0.016564183,
0.042677443,
-0.009602425,
0.005951503,
0.007021773,
0.011569588,
0.034888808,
-0.01657752,
0.011829654,
-0.01936489,
-0.008908916,
0.00800202,
-0.022952462,
0.061508864,
-0.00414438,
-0.008655519,
-0.0018904774,
0.024392826,
0.000685173,
-0.121097244,
-0.015697297,
-0.010069209,
0.032328162,
-0.00719515,
0.0005438873,
-0.008982268,
0.02708684,
-0.006781712,
0.016297448,
-0.013923516,
-0.014496994,
-0.010335943,
0.009495731,
0.0062082345,
-0.013450063,
0.01455034,
0.0021405404,
-0.0442245,
0.024312805,
-0.025393078,
0.0033241727,
0.0049179085,
-0.011242839,
-0.0037042687,
-0.023459258,
-0.013450063,
-0.010275928,
0.009148977,
0.0026690073,
0.019298207,
0.002148876,
0.025339732,
-0.00711513,
-0.008728871,
0.00094357156,
0.025139682,
-0.028167112,
0.040916998,
-0.035235565,
-0.008855569,
-0.013296691,
0.020271786,
0.017604446,
0.022832433,
0.0028040414,
-0.033208385,
0.0039443295,
0.01423026,
-0.008995605,
-0.029767517,
-0.0208586,
-0.029607477,
-0.03726274,
0.03464875,
-0.038036272,
0.0023072492,
0.04014347,
-0.02894064,
-0.0065749935,
0.023752663,
-0.009282344,
-0.0058614803,
0.022432331,
-0.0040443544,
-0.031154534,
-0.00228391,
-0.057507854,
0.011529578,
-0.028273806,
0.0031674665,
0.016390806,
0.007535236,
-0.025619803,
-0.02870058,
0.015977368,
-0.022459004,
0.00677171,
0.003367517,
-0.023445921,
-0.0065783276,
-0.006888406,
0.027900377,
-0.021925537,
-0.010622682,
0.03371518,
0.020151755,
-0.0045211418,
0.0107360445,
-0.025233038,
0.0004363602,
0.01334337,
0.0018137913,
-0.02004506,
-0.036649253,
0.017271027,
-0.0061548874,
0.017964536,
0.040196817,
0.015964031,
-0.022378985,
-0.046358373,
-0.04939914,
0.012156403,
0.004907906,
-0.026860116,
0.010095882,
-0.00013545087,
0.013236675,
0.0068350593,
0.012916595,
0.016404143,
-0.006568325,
0.00982248,
0.0026389996,
-0.015150492,
-0.016524171,
-0.008835564,
0.017337712,
0.005468047,
0.020965293,
0.022245618,
0.006291589,
0.002095529,
-0.016844254,
0.021512099,
-0.015763981,
-0.0036509219,
-0.010936094,
0.03198141,
0.01054933,
-0.012189745,
0.006511644,
-0.027580297,
-0.010215913,
-0.0015270523,
0.011309522,
0.0041777217,
-0.000456782,
0.009155645,
0.01600404,
0.036329173,
-0.009842485,
-0.027500277,
0.0025573124,
0.013910179,
-0.011042789,
-0.008135388,
-0.032061428,
0.007975347,
0.005237989,
0.008162061,
0.006855064,
0.0005534731,
-0.00881556,
-0.019818338,
-0.022819094,
-0.002298914,
0.0033758525,
-0.008328769,
-0.010656024,
-0.0320881,
0.037582822,
-0.00013190831,
0.022779085,
0.015950695,
0.017297702,
-0.014430311,
-0.020871937,
0.0103559485,
0.019898357,
-0.033208385,
-0.025646476,
0.012296438,
-0.004397777,
0.008575499,
0.002395605,
-0.0025706491,
0.0032641576,
0.020058397,
0.006868401,
0.023432583,
0.02037848,
-0.011016115,
-0.029127354,
0.015537256,
0.021205354,
-0.011582925,
-0.0031124526,
0.0057447837,
0.00094357156,
0.02316585,
-0.0048112147,
0.020258449,
0.0033175044,
0.017711138,
-0.0121764075,
0.031127859,
0.01184299,
-0.019218186,
-0.0019554938,
0.031154534,
-0.00856883,
0.009282344,
-0.013483404,
-0.011809649,
0.004167719,
0.018457994,
-0.026019903,
-0.013103308,
-0.025032988,
0.009355696,
0.028513866,
0.020271786,
0.0034675421,
-0.0030591057,
-0.018964788,
-0.0029290728,
0.0061748927,
-0.008235413,
0.0029290728,
0.029447436,
0.00053471833,
-0.0022905783,
0.017737811,
-0.0048812325,
0.022619044,
0.013250012,
0.0337952,
-0.033208385,
0.020391816,
-0.01244981,
0.038169637,
0.020645212,
-0.03864976,
-0.008622177,
0.014790401,
-0.013936852,
0.023259206,
0.013003283,
-0.0032041424,
0.083807826,
0.016910937,
-0.013750139,
-0.020831928,
0.0038743117,
0.004774539,
-0.0056981053,
0.009022278,
0.012003031,
-0.006358272,
0.036649253,
-0.018417984,
0.034382015,
-0.016710887,
-0.038916495,
-0.0021988885,
0.016084062,
0.0009844152,
-0.008735539,
-0.01026926,
0.017697802,
0.012709876,
0.011056125,
0.01677757,
-0.029207375,
0.0012919928,
0.048492245,
0.0008260419,
0.006261581,
-0.0036675928,
0.000084292114,
-0.015830664,
-0.026393332,
0.0015687294,
0.034488708,
-0.021925537,
0.006698358,
0.0007785299,
0.030007577,
0.019911695,
-0.007015105,
0.0073952004,
-0.01807123,
-0.015590603,
-0.0064983075,
-0.013603435,
0.0027073503,
-0.018698055,
-0.023419246
] |
INTRODUCTION Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mechanisms underlying this are not known. Nitric oxide (NO) inhibits WPB exocytosis, and bioavailability of endothelial NO is decreased in sepsis. We hypothesized that endothelial NO bioavailability would be inversely correlated with ang-2 concentrations in sepsis. METHODS Plasma ang-2, vascular endothelial growth factor (VEGF | [
-0.023713369,
-0.014865692,
-0.0049884426,
-0.018359594,
-0.0050980425,
0.019050404,
-0.036798898,
-0.0031335524,
-0.028960867,
-0.010169515,
0.005386987,
0.01165077,
0.0010760688,
0.026078064,
-0.01156442,
0.00047368617,
0.03536414,
0.025732659,
-0.014759414,
0.0016946425,
-0.0068615996,
0.02606478,
0.0061575053,
-0.009398997,
-0.005934985,
0.008827751,
0.009638123,
-0.054467686,
-0.010740762,
-0.036931746,
0.0004861407,
-0.0035271146,
-0.020644581,
0.024497174,
0.015649496,
-0.0006746188,
0.00025905363,
-0.00010876931,
0.019874062,
0.00838271,
0.025520103,
0.013258231,
0.0059947665,
-0.0073730643,
-0.022185618,
-0.018359594,
0.0025008637,
-0.013397722,
-0.013264874,
0.021096263,
0.005938306,
-0.03291974,
-0.004530117,
-0.0039821193,
-0.016884983,
-0.012029387,
-0.005768925,
0.017097538,
0.004098361,
-0.023514098,
-0.008987168,
0.00014571765,
-0.025719374,
0.014613281,
-0.021547947,
-0.012222017,
-0.005476659,
0.024364324,
-0.0017984299,
0.00021234924,
0.039960682,
0.03071446,
-0.024085345,
-0.018558867,
0.01645987,
-0.013331298,
-0.028243486,
-0.020113189,
-0.03456705,
-0.0031318918,
0.02056487,
-0.025028564,
-0.014918831,
0.024829293,
0.018585436,
-0.020206181,
-0.009007095,
0.021787073,
-0.0013293104,
0.0097244745,
0.039615277,
0.010368787,
0.019621652,
0.010860325,
-0.0045832563,
0.020538302,
-0.010773974,
0.014387439,
0.016087893,
-0.032468054,
-0.006781891,
-0.024935571,
-0.0014895583,
-0.02258416,
-0.015583072,
-0.0034141939,
-0.0003265155,
-0.00011042991,
0.029571967,
0.024072058,
-0.026436754,
0.03796796,
0.008880889,
-0.029040575,
0.029545397,
0.004364057,
0.025081703,
0.014453864,
-0.007652045,
-0.016884983,
0.006602546,
0.021122834,
0.027738664,
-0.028429475,
0.021866782,
0.006054548,
0.0014978613,
-0.0048356676,
-0.024111914,
-0.018054044,
0.0031318918,
0.017456228,
0.019276246,
-0.01707097,
-0.02069772,
0.0220262,
-0.03658634,
-0.0073265675,
-0.018970696,
-0.046523374,
0.011219014,
0.020883707,
-0.018572152,
-0.006934666,
-0.008734756,
0.03756942,
0.035496987,
0.012328295,
0.034992166,
0.015157958,
-0.014281161,
-0.015516647,
0.00090253615,
-0.024935571,
-0.009259506,
0.009943673,
-0.009226294,
0.039960682,
-0.018333025,
-0.011584346,
-0.022823287,
-0.016101178,
0.022610731,
-0.017403089,
0.021627655,
0.007120653,
-0.017748494,
0.0019429021,
-0.012613919,
-0.006961236,
-0.01364349,
0.015224382,
-0.019781068,
0.027140848,
0.0149321165,
0.020272607,
0.01436087,
0.012354865,
0.008004093,
-0.03528443,
-0.0037197443,
0.024948856,
0.015556502,
0.015755774,
-0.019555228,
-0.016911551,
0.04264421,
-0.022902997,
0.015503363,
-0.013424291,
-0.0149321165,
0.018306457,
-0.018133754,
-0.028137209,
-0.6410714,
-0.027167417,
0.01103967,
-0.0065759765,
0.012686985,
-0.00633685,
0.0063966317,
0.005503229,
-0.017775064,
0.038207088,
-0.016366875,
0.030528473,
-0.017031115,
-0.0037263867,
-0.0024277973,
-0.025785798,
-0.036214367,
-0.022544308,
0.02207934,
-0.009671335,
-0.011923109,
0.003351091,
0.0014206434,
0.014533572,
0.0016597698,
0.0112987235,
0.027526107,
-0.017775064,
-0.020325745,
0.021189258,
-0.0015999882,
0.034248218,
0.007200362,
0.0097244745,
0.049260043,
-0.0037961318,
0.016831843,
0.008077159,
-0.01645987,
0.027871512,
-0.01181683,
-0.0048223827,
0.009551772,
-0.013118741,
-0.009996813,
0.019767784,
0.01638016,
0.010906821,
-0.014241306,
-0.0008568697,
0.014135028,
0.010030025,
-0.0045367596,
0.016220743,
0.0062438566,
0.006389989,
0.012686985,
-0.023979066,
-0.0062903534,
0.01742966,
0.007034302,
0.026357045,
-0.0059980876,
-0.029545397,
0.01530409,
0.014945401,
-0.012959323,
0.0049186978,
0.008767969,
0.0055962224,
0.0319898,
0.019980341,
0.019741215,
-0.0055165137,
0.036347214,
0.023274971,
0.0021073015,
0.01867843,
-0.022531023,
-0.00838271,
-0.01676542,
0.011624201,
-0.017283525,
0.036612913,
0.02302256,
0.012547495,
-0.02105641,
0.009903819,
0.001922975,
-0.009790898,
0.016260596,
0.0020608047,
-0.043627284,
-0.026210912,
-0.020790713,
0.04253793,
-0.0002667339,
0.015078249,
0.01734995,
-0.018505728,
-0.011803546,
-0.00204752,
-0.00040477127,
-0.01806733,
0.015529932,
0.016087893,
-0.04686878,
-0.011730479,
0.03605495,
-0.027765233,
0.020843852,
-0.006549407,
0.0028877836,
-0.022743579,
-0.004460372,
-0.02110955,
0.010328933,
-0.0013234983,
-0.0038060956,
-0.02233175,
-0.02133539,
-0.006947951,
0.00046994982,
-0.0027167418,
0.028801449,
0.009139943,
-0.027605817,
-0.009903819,
-0.031033294,
-0.032972876,
-0.000014400516,
-0.007950953,
0.018399449,
-0.00046081652,
0.024630021,
-0.0035802538,
0.027233843,
0.010940034,
0.00059407967,
-0.029704815,
-0.007266786,
-0.00093657844,
0.012799906,
-0.011052954,
-0.0053305263,
0.00130025,
0.0014189827,
0.0125342095,
0.02271701,
-0.0047858497,
0.0051545026,
-0.0045400807,
-0.008143583,
-0.00020062125,
0.01770864,
-0.0023862824,
0.0036865321,
-0.011703909,
-0.009551772,
-0.005240854,
0.0026503177,
0.004061828,
-0.014732844,
-0.009638123,
-0.019674791,
-0.014347585,
0.0014131707,
0.0075922636,
0.0100233825,
-0.030581612,
0.009571699,
-0.006333529,
-0.012142308,
0.020099904,
-0.0032929701,
0.019528657,
-0.013258231,
-0.0141084585,
-0.0071073687,
0.0019163325,
0.0062903534,
-0.029811094,
0.00097145105,
0.021840213,
0.03735686,
0.012753409,
0.008794538,
0.02565295,
0.0032780247,
0.023235116,
-0.005669289,
-0.004144858,
-0.008628478,
0.020923562,
-0.008176795,
-0.032255497,
0.012069242,
0.0057124645,
0.0045434018,
0.03865877,
0.03201637,
-0.00024597638,
0.0014580069,
0.001087693,
-0.0009050271,
-0.019369239,
-0.019196536,
-0.016127748,
0.027871512,
0.010866967,
0.00785796,
0.010123018,
-0.007632118,
0.009751044,
-0.00044213477,
-0.02532083,
0.000012486935,
-0.012075884,
0.009757686,
-0.011471425,
-0.015171243,
-0.01831974,
-0.0041016825,
-0.00030347466,
-0.028429475,
0.014759414,
0.037170872,
0.024191622,
-0.0064364863,
-0.022291895,
-0.013749769,
0.0012603955,
0.03339799,
-0.016698996,
0.001663091,
0.0067154667,
0.012686985,
0.0011134323,
0.032335207,
0.023195263,
0.013789623,
-0.0036068235,
0.014746129,
-0.0038094167,
0.024975426,
-0.009704547,
0.023793079,
0.019183252,
-0.029199993,
0.008429206,
0.024895716,
0.016101178,
-0.018744854,
-0.0044171964,
-0.008349498,
0.0050116912,
0.006748679,
-0.0014123404,
0.01804076,
0.015782343,
0.03738343,
0.0006663158,
-7.8002796e-7,
-0.009153228,
0.0041282517,
-0.00082614855,
0.019262962,
-0.025148127,
-0.01865186,
0.003749635,
-0.012275156,
0.007811463,
0.011889896,
-0.016924836,
0.0071472228,
-0.00047327104,
0.010242581,
-0.0022899676,
0.016499722,
0.028509183,
0.010667695,
-0.022145763,
0.02670245,
0.034912456,
-0.004496905,
-0.008528843,
-0.006928024,
-0.009046949,
-0.0068682423,
0.023952495,
0.007944311,
0.012620561,
0.0057290704,
-0.005675931,
-0.011165875,
-0.0063600983,
0.016433299,
-0.028828017,
0.025799083,
0.0006522007,
0.0035271146,
0.0024012278,
-0.0136567755,
-0.011451499,
0.010289079,
0.010275793,
0.0011258869,
-0.01070755,
-0.015862051,
-0.008542127,
0.0014023768,
-0.0012446198,
0.003782847,
-0.018545583,
-0.0001570305,
0.007087441,
-0.0027233842,
0.0037031383,
0.013078886,
-0.0031617826,
-0.003550363,
-0.019382525,
0.0159949,
-0.007818106,
0.016260596,
0.009292718,
0.018080615,
0.023514098,
0.008847677,
0.008555411,
-0.022477884,
-0.0062671048,
0.006213966,
-0.011903182,
0.0011200748,
-0.00057747366,
0.01798762,
-0.014055319,
0.021401815,
0.019236391,
0.0010644447,
-0.039535567,
-0.0052707447,
0.0015642853,
-0.012281799,
-0.0040551857,
0.015529932,
0.021481523,
0.022265326,
0.0024726335,
-0.0015651156,
0.018811278,
-0.0071272957,
-0.006768606,
-0.00617079,
0.01671228,
-0.003309576,
-0.008050589,
-0.016805273,
-0.038951036,
-0.013616921,
0.014467148,
0.032228928,
0.00749927,
0.006672291,
0.039827835,
-0.0059117363,
-0.0078048203,
-0.021215826,
-0.021136118,
0.011936394,
0.004035258,
-0.008568697,
-0.03196323,
0.016752133,
-0.0036267505,
-0.015875338,
-0.036187798,
0.013949041,
0.0040883976,
0.0035071874,
0.0071671503,
-0.02509499,
-0.002396246,
-0.012793263,
-0.02235832,
0.016420014,
-0.012886257,
-0.009412281,
-0.010362145,
-0.020883707,
-0.00088343926,
-0.011610916,
-0.0034706541,
0.006522837,
-0.015848767,
-0.041103173,
0.0067353942,
0.0014015465,
0.014626565,
-0.00116242,
-0.0012927771,
-0.011830115,
0.0014364191,
-0.014772698,
-0.016234027,
0.0024593489,
-0.029518828,
0.009558414,
0.0009988509,
-0.011610916,
-0.0097244745,
0.0049353037,
-0.01824003,
0.01898398,
-0.0065826187,
0.031750675,
-0.014254591,
0.03735686,
0.009232936,
0.017442944,
-0.00094156025,
-0.008070516,
0.0041149673,
0.009990171,
-0.051040206,
-0.0059217,
-0.01270027,
0.0014771038,
0.009737759,
0.000032433596,
-0.005722428,
-0.00024016429,
0.012514282,
-0.011889896,
-0.005473338,
0.00152194,
-0.008110371,
-0.0007447791,
0.017575791,
0.0071073687,
0.0029209957,
0.021162689,
-0.0024344397,
-0.01865186,
0.014613281,
0.022836573,
-0.0058585973,
-0.009226294,
0.00045002264,
0.0031501583,
-0.011444856,
-0.010076522,
0.002163762,
-0.011776976,
0.008004093,
0.0045566866,
-0.005768925,
-0.02672902,
-0.014507002,
-0.018412733,
-0.004799134,
0.017496083,
-0.018054044,
-0.017110823,
-0.02000691,
-0.007911099,
0.011232299,
0.03818052,
-0.027605817,
-0.015104819,
0.007950953,
-0.023766508,
-0.010946676,
-0.025121558,
-0.0033378063,
-0.012999178,
0.0024078703,
-0.031192712,
-0.051970143,
-0.032282066,
-0.01367006,
0.02366023,
0.027008,
0.03273375,
0.0012936075,
0.01732338,
0.02741983,
-0.000611516,
0.037542846,
-0.011929751,
0.0039621918,
-0.0151181035,
0.042431653,
0.0064065955,
0.0017901269,
0.016513007,
-0.014639851,
0.03539071,
0.0058951303,
-0.020657865,
-0.02703457,
-0.0055364408,
-0.03323857,
-0.0037297078,
0.027844943,
-0.02601164,
-0.0110728815,
-0.034939025,
-0.0036035022,
0.0025191305,
-0.016340306,
0.00018712887,
-0.0010594629,
0.018027475,
-0.011365147,
0.035842393,
0.0008792878,
0.014095174,
0.0011615898,
-0.010408642,
0.0131320255,
-0.005347132,
0.030315915,
-0.00009548451,
0.004912055,
-0.0026835299,
-0.015888622,
-0.009844038,
0.01220209,
-0.013763053,
-0.017217102,
0.002363034,
-0.0037928107,
-0.006350135,
-0.00982411,
-0.019116828,
-0.03730372,
0.00091166946,
-0.005377023,
-0.018452588,
0.013596994,
-0.020950131,
-0.013776339,
0.026822014,
-0.018160323,
0.014746129,
-0.0024394216,
0.037675694,
0.0013176862,
-0.013112099,
-0.022504453,
0.004364057,
-0.015702635,
0.023314826,
0.017283525,
0.016938122,
-0.020458594,
-0.011989533,
-0.008894174,
0.02056487,
-0.0020757501,
-0.021787073,
0.04253793,
-0.01939581,
0.015742488,
-0.017057685,
-0.028163778,
-0.024444034,
0.0061807535,
0.004035258,
-0.0097244745,
0.01270027,
-0.0046197893,
-0.0018831205,
0.0028794806,
-0.0018681751,
0.018412733,
0.015091534,
0.0019943807,
-0.016845128,
0.009618196,
-0.0058320276,
-0.00041099853,
-0.0230757,
0.012361507,
-0.015157958,
0.016087893,
0.010335575,
0.009458778,
0.012467786,
0.011836758,
0.0033361455,
0.04131573,
-0.005157824,
-0.00025199607,
0.03748971,
-0.02567952,
0.015742488,
-0.011385075,
-0.0072601438,
-0.03066132,
-0.012746766,
0.009571699,
0.024364324,
0.02177379,
0.00068541267,
0.0017901269,
-0.035018735,
-0.010966603,
-0.022956137,
-0.02102984,
0.004061828,
-0.041581426,
-0.0045168325,
-0.016552862,
-0.010548132,
0.009359142,
0.0029243168,
0.0022866463,
-0.0032149218,
0.01663257,
-0.016446583,
0.0024410821,
0.00204752,
0.004905413,
-0.0153838,
-0.012560779,
-0.012414646,
0.0093525,
0.000802485,
0.0027582569,
-0.023181977,
0.020870423,
-0.007652045,
0.016552862,
0.010734119,
-0.011637486,
0.021255681,
-0.0015020128,
0.007379707,
-0.021574516,
0.010767331,
0.0253474,
-0.009591626,
0.014839123,
0.028216917,
-0.013975611,
-0.023553953,
0.022703724,
0.017442944,
-0.01248107,
0.016977975,
-0.03685204,
-0.023872787,
-0.005323884,
-0.010973246,
-0.021627655,
-0.009246222,
-0.026383614,
-0.017509367,
0.023102269,
0.008103728,
-0.023899358,
-0.009412281,
0.013039032,
-0.011982891,
0.009525202,
-0.0054633743,
-0.010528205,
0.00401201,
-0.013225019,
-0.00752584,
0.005941627,
-0.01505168,
0.013842762,
0.00058037974,
-0.0085620545,
-0.023341395,
0.005639398,
-0.055796165,
-0.00296085,
0.0034341211,
0.016752133,
0.015888622,
0.008588624,
-0.0029259773,
0.014812553,
0.0065925824,
0.02728698,
-0.031803813,
-0.02003348,
0.017828204,
-0.02271701,
0.02332811,
0.0028828017,
-0.038472783,
-0.023859503,
0.030289346,
0.013603636,
-0.013517285,
0.0259585,
0.0028097355,
0.0043706996,
-0.012846403,
0.0035304357,
0.023195263,
0.010773974,
0.029412549,
-0.043892983,
-0.0035769327,
0.0091997245,
0.011272154,
0.0014704614,
0.0016506366,
0.024165053,
0.0038891255,
-0.0025274334,
-0.009073519,
-0.026024925,
0.017907912,
0.013251589,
0.01768207,
0.03544385,
-0.014825838,
0.032414913,
0.014746129,
0.00954513,
-0.010242581,
0.010800543,
-0.010601271,
0.006250499,
0.0148922615,
0.005822064,
-0.02741983,
0.0025191305,
0.008216649,
-0.03555013,
0.0013600315,
0.0045367596,
0.0075856214,
-0.0036499992,
-0.002437761,
0.02631719,
0.006798497,
-0.005074794,
-0.013935756,
-0.006981163,
-0.021986345,
-0.0112588685,
-0.012985893,
0.022982705,
-0.023753224,
0.0030621467,
-0.007871244,
-0.007984165,
0.008442491,
-0.008548769,
0.002749954,
0.023221832,
0.18343653,
-0.0130589595,
0.0006546916,
0.018718284,
-0.0059117363,
-0.018080615,
0.007226932,
-0.00583867,
0.008376067,
0.008781253,
0.013949041,
0.0006629946,
-0.01604804,
-0.004606505,
0.004643038,
-0.024802724,
-0.030129928,
-0.0017851451,
0.00064763403,
-0.0024394216,
0.0039057315,
-0.019714644,
0.027658956,
-0.007220289,
0.038393073,
-0.006506231,
-0.014613281,
0.0020857137,
0.033610545,
0.00459322,
0.008920744,
0.010906821,
0.0011989533,
0.02437761,
-0.00766533,
-0.009604911,
-0.0068948115,
-0.0010802203,
0.021654226,
0.011790261,
-0.0093857115,
-0.0012180501,
-0.016393444,
-0.007937669,
-0.0077317543,
0.019714644,
-0.020378884,
-0.011086166,
-0.016114464,
0.01353057,
-0.037649125,
-0.0064099166,
0.012999178,
0.015463509,
0.0072601438,
-0.0018100542,
0.023766508,
0.019143399,
-0.0148922615,
-0.0055165137,
-0.013709915,
0.010534847,
-0.032282066,
0.00915987,
-0.010860325,
0.016924836,
-0.019621652,
-0.0034540482,
-0.0214151,
-0.009565056,
0.0098373955,
-0.018333025,
-0.006821745,
0.006516195,
-0.026755588,
-0.00785796,
0.013829478,
0.01964822,
0.010461781,
-0.005808779,
0.012620561,
-0.003301273,
-0.025121558,
-0.008973883,
-0.013802908,
-0.041634567,
0.008734756,
0.008774611,
-0.03666605,
-0.009292718,
0.00091166946,
-0.036294077,
-0.025440393,
0.008322928,
0.012142308,
-0.028562322,
-0.0053803446,
0.006469698,
-0.011112736,
-0.0041382154,
-0.02728698,
0.09692591,
0.019847492,
0.0070077325,
-0.0052840295,
0.010946676,
-0.013324656,
0.033716824,
-0.005024976,
0.007067514,
-0.026024925,
-0.009538487,
0.009784256,
-0.005941627,
-0.007094084,
0.012447858,
0.020086618,
-0.0062837107,
0.024802724,
-0.024390895,
-0.019050404,
-0.03345113,
0.008847677,
0.028243486,
-0.0015825519,
0.020551587,
-0.029598536,
0.018306457,
-0.017004546,
-0.037224013,
-0.010920106,
0.00296085,
-0.013417649,
0.012348223,
0.030927017,
0.015583072,
-0.00459322,
0.012932754,
0.007877887,
0.037542846,
-0.0032813458,
-0.0061940383,
0.004078434,
0.014254591,
0.016566146,
0.00048074374,
0.046842206,
0.00078131235,
-0.016539577,
-0.01798762,
-0.025838938,
-0.0209767,
0.003613466,
0.0021421742,
0.012547495,
-0.030448765,
-0.026543032,
-0.031484976,
0.010873609,
-0.0042876694,
-0.0058453125,
-0.0013218377,
0.013344582,
-0.035496987,
-0.0015518308,
-0.01604804,
-0.16760105,
0.006954593,
0.022092624,
-0.0049651945,
0.037330292,
-0.0031983159,
-0.010760689,
0.021454953,
0.005327205,
0.00012423364,
0.04152829,
-0.019103544,
-0.006635758,
-0.017721925,
-0.0004956891,
0.026197627,
0.022544308,
0.023793079,
0.005024976,
0.010508277,
0.029146854,
-0.008316285,
0.032946307,
-0.01831974,
-0.003193334,
0.002221883,
0.0036433567,
0.005775567,
0.006137578,
0.0021488166,
-0.015955046,
-0.0018366238,
0.04142201,
0.017947767,
-0.0052541387,
-0.0034606906,
0.0032896488,
0.006453092,
-0.002598839,
0.029173423,
0.039801262,
0.007818106,
-0.0074461307,
0.0018964054,
-0.034806177,
0.028854588,
-0.0017087575,
-0.0038725194,
0.021627655,
-0.021800358,
0.020139758,
-0.0013965647,
-0.019515373,
0.025001995,
-0.009279434,
0.015370514,
-0.012155592,
0.009658051,
0.005191036,
-0.00093242695,
-0.012886257,
0.0046862136,
-0.001463819,
0.010933391,
-0.00017353271,
-0.032388344,
0.007047587,
0.007917741,
-0.01734995,
-0.00004826119,
-0.025254406,
-0.031617828,
0.00050274667,
-0.023142124,
0.03746314,
0.01995377,
-0.023500813,
0.0009863965,
0.01533066,
0.030342486,
-0.0017884664,
0.013158595,
-0.016791988,
-0.02266387,
-0.0090868035,
0.029412549,
0.0015933458,
0.010315648,
-0.0074461307,
-0.01665914,
-0.00558958,
-0.02470973,
0.018930841,
-0.03446077,
0.015211097,
0.012168878,
0.012859687,
0.006639079,
-0.0017087575,
0.007838032,
0.047214184,
0.0068283877,
-0.015875338,
0.012926111,
0.0065992246,
0.0070143747,
-0.013922472,
0.0028678563,
0.04524803,
-0.008402636,
-0.015317376,
-0.006688897,
-0.0009465421,
0.0013691648,
-0.003613466,
0.033796534,
-0.0016647516,
-0.0022368284,
-0.0049552307,
-0.035204723,
0.061854035,
0.011776976,
0.0055530467,
0.016433299,
-0.022836573,
-0.05547733,
-0.1284906,
-0.039880972,
0.01635359,
0.02736669,
-0.013749769,
-0.0035403995,
-0.0130589595,
0.023846218,
0.0061408994,
0.013158595,
-0.0099104615,
-0.004330845,
-0.0052773873,
-0.0032913093,
0.057018366,
0.0039057315,
0.0051013636,
-0.013497358,
-0.0061442205,
0.03791482,
-0.015197813,
-0.0081502255,
0.013510643,
0.0041282517,
-0.011132663,
0.0039754766,
-0.007917741,
0.02025932,
-0.014400724,
0.009717832,
0.01742966,
-0.0026021604,
0.028907727,
-0.0025822332,
-0.027924651,
-0.03183038,
-0.0037529562,
-0.032255497,
0.014321015,
-0.020139758,
-0.008004093,
0.01742966,
0.02207934,
-0.0096115535,
-0.023062414,
0.006848315,
-0.029518828,
0.0019844172,
0.013869332,
-0.031059865,
-0.01665914,
-0.018851133,
-0.03528443,
0.006071154,
0.020764144,
0.0021239074,
0.015264236,
0.022849858,
-0.01834631,
0.0026353723,
-0.0036433567,
0.01364349,
-0.024869148,
-0.003965513,
0.0017004545,
-0.015370514,
-0.009106731,
-0.02736669,
0.01250764,
-0.019595081,
-0.010162872,
0.0059814816,
0.0111459475,
-0.002897747,
-0.027260412,
-0.012653773,
0.0015775701,
-0.016433299,
0.014148313,
0.0023514098,
-0.026436754,
-0.019156683,
0.021946492,
-0.01369663,
0.0127201965,
0.007970881,
0.019382525,
-0.0010561417,
0.014201452,
-0.015490077,
-0.0153439455,
0.023567237,
0.009226294,
-0.007366422,
0.00032838367,
-0.0063600983,
-0.009332573,
-0.025971785,
0.018824562,
0.006237214,
0.0019810959,
-0.011438213,
-0.062332287,
0.010621198,
-0.0035071874,
-0.0075856214,
0.012474428,
-0.022145763,
0.006101045,
0.005350454,
0.010235939,
-0.0028545717,
-0.033876244,
0.028270056,
-0.023832932,
-0.006795176,
-0.0236868,
-0.017522652,
0.032414913,
0.017243672,
0.013935756,
0.008063874,
-0.001665582,
-0.015875338,
0.0044171964,
0.009956959,
0.012427932,
-0.001698794,
-0.018532297,
-0.00564604,
0.005124612,
0.0009556754,
0.016513007,
-0.044610362,
0.0012421289,
-0.01103967,
-0.011478068,
0.00039605313,
-0.025865508,
0.03196323,
0.009027022,
0.006499589,
-0.027167417,
-0.016366875,
0.012182162,
-0.014387439,
0.009458778,
-0.0029674924,
-0.0148922615,
0.01117916,
-0.0058519547,
-0.008276431,
0.02736669,
0.020272607,
-0.014121743,
-0.027951222,
-0.012560779,
0.013271516,
-0.01627388,
0.007047587,
0.009624838,
-0.007658688,
0.04325531,
-0.0077516814,
0.015250951,
0.00057290704,
0.016194172,
0.0067121456,
-0.015091534,
0.004327524,
0.017947767,
-0.025227837,
-0.018120468,
-0.039774694,
-0.014121743,
0.019741215,
0.00985068,
-0.0010602932,
-0.000075142154,
0.0069413083,
-0.0068615996,
0.011949679,
0.02235832,
-0.00040186523,
-0.012514282,
0.024085345,
0.032175787,
0.0013741466,
0.0021903315,
0.03151155,
-0.0045600077,
-0.0049651945,
-0.02338125,
0.000794182,
-0.0004012425,
0.01129208,
0.017150678,
0.016034754,
-0.008236577,
0.019940486,
0.014799268,
0.03140527,
-0.010926749,
0.010740762,
0.0014779341,
-0.01663257,
0.005496586,
0.017668786,
-0.021986345,
-0.037224013,
-0.023181977,
-0.009053592,
0.006549407,
0.0064132377,
-0.004310918,
-0.00035744417,
-0.02258416,
0.008947314,
-0.021122834,
0.0019345991,
-0.021229113,
0.035311002,
0.006615831,
-0.009040307,
-0.015370514,
-0.004908734,
0.022863142,
0.0003954304,
0.02667588,
-0.00406847,
0.026715735,
-0.014573427,
0.0020558229,
-0.0036267505,
-0.035231292,
-0.0020558229,
0.015676064,
-0.003666605,
-0.0028064142,
0.026171058,
0.0027150812,
0.09426895,
0.013198449,
-0.013523927,
-0.004729389,
-0.00835614,
-0.002678548,
-0.009239579,
0.039455857,
-0.008734756,
-0.033052586,
0.0065593706,
-0.010780616,
0.034885887,
-0.031617828,
-0.023726655,
-0.00785796,
-0.0065792976,
-0.0019893989,
0.0010959961,
-0.003032256,
0.010202727,
-0.014188168,
0.009458778,
0.023646945,
-0.040996894,
0.0032730429,
0.038924467,
-0.015144673,
0.00918644,
-0.055743024,
-0.014254591,
0.013537212,
-0.027313551,
-0.0130589595,
0.016087893,
-0.014241306,
-0.016194172,
-0.03738343,
0.017721925,
0.024311185,
0.0010918445,
0.022531023,
-0.030209638,
-0.021375244,
0.008469061,
-0.019847492,
-0.040332656,
-0.0071937195,
-0.014812553
] |
A number of authors have attempted to defend ecologic (aggregate) studies by claiming that the goal of those studies is estimation of ecologic (contextual or group-level) effects rather than individual-level effects. Critics of these attempts point out that ecologic effect estimates are inevitably used as estimates of individual effects, despite disclaimers. A more subtle problem is that ecologic variation in the distribution of individual effects can bias ecologic estimates of contextual effects. The conditions leading to this bias are plausible and perhaps even common in studies of ecosocial factors and health outcomes because social context is not randomized across typical analysis units (administrative regions). By | [
-0.014253806,
0.010667491,
0.028821168,
-0.016566293,
-0.008936391,
0.025019284,
-0.007649499,
-0.0031061799,
-0.016997434,
-0.033184845,
-0.023921832,
0.0043048845,
0.0069178645,
0.010674023,
-0.006258087,
0.0038443469,
0.055395175,
0.0080283815,
-0.01618741,
0.015455777,
-0.03519684,
0.02756694,
-0.026704656,
-0.016226606,
-0.0030604529,
-0.00092352513,
0.023634404,
-0.03242708,
0.0091258325,
0.0015245106,
0.00943939,
-0.0057224263,
-0.024731856,
-0.033498403,
-0.03527523,
-0.02207968,
-0.011719216,
0.0009047443,
0.0023582145,
-0.011033308,
0.03271451,
0.001517978,
-0.012294071,
-0.020093815,
0.004892805,
0.0123789925,
0.0150377,
-0.016592423,
-0.0315648,
0.0076429667,
0.032975808,
0.02359521,
-0.0327929,
0.0061764317,
-0.012646823,
-0.019950103,
0.0011382794,
-0.0052161613,
0.023634404,
-0.040213764,
-0.005921666,
0.025176063,
-0.023712793,
-0.002410474,
-0.019963168,
-0.014946246,
-0.0007826692,
0.018865716,
-0.0039325347,
0.009746416,
0.013077965,
0.02098223,
-0.0047360263,
-0.013848794,
0.01431913,
0.0052945507,
-0.01690598,
0.004170969,
0.01631806,
0.0077801477,
-0.0026097137,
-0.012274474,
-0.021125942,
0.028167924,
-0.0017572291,
0.0003821483,
-0.0035307892,
0.00847912,
-0.019780258,
0.0075711096,
-0.016553229,
-0.012065435,
0.0038247495,
0.0011987046,
0.0032204979,
0.019492831,
-0.0030098264,
0.028298574,
0.0067022936,
-0.020603348,
-0.0053990697,
0.0017621284,
-0.015690945,
-0.011059438,
-0.029944751,
-0.0009390397,
-0.0015081794,
0.016017567,
0.0060033216,
-0.019832518,
-0.010203687,
0.017441642,
-0.0027844568,
-0.0055558486,
0.037182704,
-0.014854792,
0.025136868,
-0.0024513018,
-0.0054023364,
-0.009615767,
0.019479766,
-0.0102951415,
0.016487904,
-0.023895701,
0.0122418115,
-0.010308206,
-0.013104095,
-0.009151963,
-0.010981048,
-0.009106236,
-0.011555904,
0.014698013,
0.008740418,
-0.0043800077,
-0.02991862,
0.02036818,
0.013404587,
0.015181414,
-0.0084856525,
-0.030232178,
0.013417652,
-0.0067545534,
-0.005637504,
-0.026325773,
0.0009357735,
0.03396874,
0.019427506,
0.04609297,
0.00754498,
-0.008185159,
0.008995184,
0.003909671,
0.014293001,
0.009864,
-0.007884667,
-0.0037855548,
0.005905335,
0.02234098,
-0.028376963,
-0.025620269,
0.0056538354,
-0.004076249,
-0.0027632264,
-0.00043930727,
0.023294717,
0.02997088,
0.012019708,
-0.010576037,
0.005036519,
-0.012202617,
-0.014867856,
0.029160857,
-0.014946246,
0.020172205,
-0.014214612,
0.012326733,
-0.011889059,
0.033472273,
-0.0049581295,
-0.031590927,
0.0006475291,
0.014854792,
0.009661494,
-0.009955454,
0.0057256925,
-0.008257017,
0.01690598,
-0.00024047581,
0.00036908343,
-0.0024072079,
0.00062017445,
0.012176487,
-0.0039358013,
-0.010301674,
-0.64843714,
-0.006898267,
0.0050887787,
-0.012620693,
-0.004719695,
-0.0048503443,
0.02431378,
0.023712793,
-0.006313613,
0.040762488,
-0.018055692,
0.022236459,
0.009027846,
-0.014123157,
-0.010739348,
-0.018434573,
0.0010549907,
-0.019414442,
0.03135576,
-0.009850934,
-0.028429223,
0.028977947,
-0.0076690963,
-0.0063626063,
0.007473123,
0.034465205,
-0.0010574403,
-0.016801462,
0.016357254,
0.0043179495,
-0.0023435163,
0.019074755,
-0.0013122059,
-0.003442601,
0.045309074,
-0.0020381245,
0.00090637745,
0.021844514,
0.0040958463,
0.026495617,
-0.038097247,
-0.008361536,
0.0063201454,
-0.008172095,
-0.005706095,
0.036189772,
0.012999576,
0.004765422,
-0.010556439,
-0.0055231866,
-0.002802421,
0.0076299016,
-0.0073947334,
-0.004396339,
0.025946891,
-0.0001682106,
0.0017735602,
-0.0043767416,
0.009681091,
0.024339909,
-0.013535236,
-0.022471627,
-0.021753058,
0.013071433,
-0.0007238771,
0.039874073,
-0.014214612,
0.016161282,
0.01301264,
-0.038358547,
0.011549371,
0.016736137,
0.008792678,
-0.022145005,
0.018708937,
-0.0024496687,
0.018003432,
-0.022301784,
-0.03493554,
0.01103984,
0.0072771492,
-0.010301674,
0.0047948183,
0.0014020271,
-0.0049679284,
-0.019205403,
-0.0023206528,
0.021870643,
-0.0019515695,
0.016762266,
-0.0028040542,
0.022706795,
-0.010863464,
-0.021674668,
-0.018303925,
0.02234098,
0.002090384,
0.012032773,
0.019166209,
-0.02098223,
-0.03166932,
0.002034858,
0.011987045,
-0.0037626913,
-0.00019107416,
0.021165138,
0.010445387,
-0.00877308,
0.04429001,
-0.011372996,
0.02205355,
0.0066271704,
0.004716429,
0.003583049,
0.0056146407,
-0.030885424,
-0.012065435,
0.013848794,
-0.006254821,
-0.024170065,
0.030963814,
0.014162351,
0.009112768,
-0.0045759813,
0.0061633666,
0.0022030687,
-0.01303877,
-0.015573361,
-0.010125297,
-0.0063822037,
0.0066108396,
-0.0027697587,
0.0074404604,
-0.014946246,
0.023046484,
0.010909191,
0.021348046,
0.0123789925,
0.011196619,
-0.012117695,
-0.028037276,
-0.022040486,
0.006284217,
-0.029500544,
-0.0053990697,
-0.026887564,
-0.027645329,
-0.0087142885,
-0.018094886,
-0.010778543,
-0.007845473,
-0.02213194,
-0.0055362512,
0.028220184,
-0.010987581,
-0.011444853,
0.004295086,
-0.023791183,
-0.012640291,
-0.025620269,
0.023712793,
0.024392169,
0.0018976767,
-0.02200129,
-0.017637614,
-0.016736137,
-0.038436934,
0.008047978,
0.017794393,
-0.033393886,
0.011085568,
-0.036268163,
0.006130704,
0.028376963,
-0.010569504,
0.0023990422,
-0.015325128,
0.00879921,
-0.01708889,
-0.023033418,
0.016226606,
-0.011372996,
-0.0014975641,
0.0073816683,
0.035980735,
-0.0027779243,
0.018081822,
-0.012045838,
-0.0135483015,
0.03399487,
0.0217008,
0.017284863,
-0.027906626,
0.015873853,
0.013874924,
0.0020381245,
0.011359931,
0.0036483733,
0.023137938,
0.05092698,
0.029265376,
0.023425365,
0.009178093,
-0.027148861,
0.028899558,
-0.011621228,
0.0076233693,
-0.005137772,
0.0021230462,
0.0059902566,
0.020538023,
-0.023961026,
-0.02863826,
-0.025999151,
-0.008544445,
0.041154437,
-0.009210754,
0.02997088,
0.0041742357,
-0.0022945232,
0.013300068,
-0.016514033,
0.028324703,
0.0037398275,
-0.021557085,
-0.0053892713,
0.008831873,
0.009981584,
0.0050691813,
0.0011635927,
-0.015246739,
0.015442712,
0.01506383,
0.0060621137,
-0.002176939,
0.00510511,
-0.001074588,
-0.0011897224,
0.019976232,
0.017310992,
-0.011307671,
0.014436714,
0.025189128,
-0.00079450925,
0.022249525,
-0.0070746434,
0.026391098,
-0.0016951708,
0.0075711096,
-0.020629477,
0.017075824,
-0.00046339567,
-0.014253806,
-0.021165138,
-0.0036222434,
-0.015338193,
0.016239671,
0.0022340978,
0.027619198,
0.021112878,
0.0032760238,
-0.01836925,
0.0037104315,
-0.010576037,
-0.0044192025,
-0.020355115,
-0.012934251,
-0.007375136,
-0.033472273,
-0.02028979,
-0.011764943,
-0.0012060535,
-0.0075841746,
-0.009380599,
0.028977947,
0.0013334363,
0.010994113,
0.01613515,
0.022811316,
0.00016392367,
-0.0123789925,
0.0037038992,
0.017585356,
0.015272868,
0.007799745,
-0.014698013,
0.009733351,
-0.017585356,
-0.024039416,
-0.012509642,
0.014488974,
0.009530844,
0.0007446993,
-0.016932111,
0.0024349708,
0.0023925097,
0.008740418,
0.0008112486,
0.009491649,
-0.01277094,
0.01964961,
-0.009243417,
-0.002903674,
0.0054643946,
0.028507613,
0.0063103465,
0.0005340278,
-0.03132963,
-0.0059151333,
-0.0055035893,
-0.009681091,
-0.0026913695,
0.013718145,
-0.00021944949,
0.0045955786,
0.015207544,
-0.009158495,
-0.013051835,
0.029944751,
0.00047319435,
0.019427506,
-0.038985662,
0.000044987144,
-0.022354044,
0.06401801,
0.016370319,
-0.02636497,
0.030153789,
0.003336449,
0.012444317,
-0.014083962,
-0.004543319,
0.008093705,
-0.008982119,
-0.031590927,
0.007603772,
0.024522817,
-0.013202081,
0.013267406,
0.04337547,
-0.0026946357,
-0.024588142,
-0.027331771,
-0.00020832391,
0.00054137676,
-0.023072613,
0.034282297,
0.03801886,
-0.0027354634,
0.007819342,
0.019388312,
0.008544445,
-0.01439752,
-0.0120785,
-0.0182386,
0.016736137,
-0.0076886937,
0.017637614,
-0.018774262,
0.02149176,
0.0030882158,
0.012228746,
0.019910907,
0.0030539203,
0.026652396,
0.016644683,
0.007904264,
-0.014593493,
0.0024333377,
-0.01365282,
0.01631806,
0.034883283,
0.018565223,
-0.0024513018,
0.012339798,
-0.015508036,
-0.0064213984,
-0.0097006885,
-0.0054545957,
-0.022641473,
0.009746416,
0.0034817958,
-0.013953313,
-0.011150892,
-0.013365393,
-0.0022847245,
0.001357933,
-0.0044257347,
-0.016775332,
-0.02346456,
-0.025816243,
-0.0068068127,
-0.0037332952,
-0.000108295775,
-0.009752948,
-0.040004723,
-0.0073816683,
-0.012731745,
0.014541234,
-0.016631618,
0.015873853,
-0.01431913,
-0.007767083,
0.018134082,
-0.022066616,
-0.015181414,
-0.02636497,
-0.031068332,
0.014410584,
0.019074755,
-0.04183381,
-0.011242347,
-0.020995295,
0.012725213,
0.011523242,
0.019937037,
-0.01442365,
-0.00047482745,
0.002436604,
0.0023631137,
0.01762455,
0.020694802,
0.010576037,
-0.03164319,
-0.011242347,
-0.010197154,
-0.012751343,
-0.018016497,
0.009674558,
0.0042656898,
-0.0300754,
0.009916259,
0.013482977,
-0.0069113323,
0.018578287,
-0.051449575,
0.011804137,
-0.013352328,
0.011791072,
0.020106882,
0.012411655,
0.010360465,
0.022040486,
-0.012646823,
-0.021844514,
-0.0046543707,
0.012300603,
-0.0077736154,
-0.039090183,
0.007884667,
-0.012294071,
-0.012829732,
-0.035902344,
0.011869461,
-0.0059379973,
0.008034914,
0.0007312261,
0.017441642,
-0.025803177,
0.012614161,
0.0026913695,
0.02869052,
-0.0367385,
-0.026417227,
-0.0057844846,
0.0069570593,
-0.038672104,
0.0036451072,
0.033550665,
-0.037835952,
-0.016644683,
0.019741064,
0.008387666,
0.023738923,
-0.008459522,
-0.0012574967,
-0.009752948,
-0.004778487,
-0.008178627,
-0.020655608,
0.00909317,
-0.009961986,
0.027723718,
0.022798251,
0.039090183,
-0.012117695,
-0.0021965364,
0.0064377296,
0.0025901163,
0.01437139,
0.003991327,
-0.0023418833,
-0.0068133455,
0.016056763,
0.0037920873,
-0.0033772767,
-0.007904264,
-0.0105237765,
0.02215807,
0.025136868,
-0.0070223836,
-0.026443359,
-0.008243952,
-0.014214612,
0.0065095862,
0.014933181,
-0.020616412,
0.006313613,
-0.008949457,
-0.003916204,
0.008047978,
0.025450425,
0.009779078,
-0.018604418,
0.019910907,
-0.0073947334,
-0.009289144,
-0.02072093,
-0.0050169216,
-0.029578933,
-0.030728646,
-0.026456423,
-0.005794283,
0.008355004,
0.0018470503,
0.018499898,
-0.005167168,
0.0029265375,
-0.004079515,
0.0015351258,
0.0020789523,
0.008688158,
0.0025345907,
-0.01746777,
0.008126368,
0.0015718708,
-0.012274474,
-0.019989297,
0.018630547,
-0.000033989152,
-0.0007099957,
0.004964662,
-0.020328984,
-0.020773191,
-0.0039978595,
-0.003367478,
0.019257663,
-0.016409514,
0.019610414,
0.0024921296,
-0.014567363,
-0.004229761,
0.028194055,
-0.0023843443,
-0.003831282,
0.025319776,
-0.021766124,
-0.015129155,
-0.005317414,
0.005415401,
-0.00055485,
-0.0055525824,
-0.028063405,
0.01621354,
0.012522707,
-0.012548837,
-0.018565223,
-0.01378347,
-0.006578177,
0.00023782201,
0.009530844,
0.003860678,
0.028220184,
-0.0020250594,
0.0047850194,
0.033263236,
0.00877308,
0.037234966,
0.0037496262,
-0.01501157,
-0.015612556,
-0.03263612,
-0.011033308,
0.012300603,
0.0030000277,
0.015468841,
0.010589101,
-0.015586426,
0.018604418,
-0.01567788,
0.009001716,
0.0021442766,
-0.047399458,
0.03383809,
-0.016618554,
-0.0031127124,
0.01690598,
0.013443782,
0.02221033,
-0.023294717,
-0.008224354,
-0.03658172,
-0.017820524,
-0.011856397,
0.018473769,
0.0044616633,
0.02085158,
-0.0030098264,
-0.0032351958,
-0.011431787,
-0.0010427423,
-0.047974315,
0.0141884815,
0.005203096,
0.021125942,
-0.006431197,
0.008596704,
0.0404228,
0.006561846,
0.011085568,
-0.00012421863,
-0.0020087285,
-0.016357254,
0.028324703,
-0.00142979,
-0.01629193,
-0.009034378,
0.01754616,
-0.015886918,
-0.018121017,
-0.0051345057,
-0.018852651,
-0.049411453,
-0.046458784,
-0.006614106,
0.028403092,
-0.004344079,
-0.007636434,
-0.00006971349,
-0.0028530476,
0.009929324,
-0.032871287,
-0.029605063,
0.010007713,
-0.009361001,
0.012810134,
0.036032993,
-0.016997434,
0.020590283,
-0.03804499,
0.01682759,
-0.0056146407,
-0.022915835,
0.014293001,
-0.018094886,
0.039769556,
0.011568969,
-0.015050765,
-0.028194055,
-0.027775977,
-0.010543374,
0.010602166,
0.0054088687,
-0.0023108541,
-0.012248344,
-0.012836264,
-0.008204757,
0.017023565,
0.010027311,
-0.0124247195,
-0.0030833164,
-0.0042003654,
-0.04703364,
-0.02351682,
-0.01431913,
0.032113526,
0.026574006,
-0.009132365,
-0.0104323225,
-0.0070811757,
-0.04922854,
-0.02607754,
0.009132365,
0.006339743,
0.021504825,
0.021596279,
-0.011235814,
0.011242347,
0.00056995626,
-0.0014265238,
-0.021217398,
-0.03010153,
0.0036483733,
0.007257552,
0.014593493,
0.011680021,
-0.035693306,
-0.001072955,
0.03511845,
-0.012137292,
-0.023582144,
0.01181067,
0.01583466,
0.010053441,
-0.014240741,
0.011190087,
0.011124763,
-0.00554605,
-0.015991438,
-0.015481907,
0.004605377,
0.018591352,
-0.009988116,
-0.015076894,
0.006026185,
-0.011150892,
-0.031930614,
0.014332196,
-0.03671237,
-0.018852651,
0.003658172,
-0.008544445,
0.011470982,
0.026195124,
0.025698658,
0.021583214,
0.0014183582,
0.009583104,
-0.01900943,
0.0033642116,
0.0014052934,
0.016095957,
0.0061339703,
-0.013887988,
-0.0011031675,
-0.0066533005,
0.0024202727,
-0.012679486,
-0.0030865825,
-0.0036451072,
0.0051867655,
-0.008034914,
0.017820524,
0.030310567,
-0.016448708,
0.007479655,
-0.009321806,
-0.01575627,
-0.012672953,
-0.032244172,
0.0048568766,
-0.03545814,
0.0150377,
-0.0055983094,
-0.013267406,
-0.010027311,
-0.005490524,
0.008844937,
-0.033341624,
0.018199407,
0.15646525,
-0.017350188,
-0.01613515,
0.026887564,
0.0052488237,
0.0025917494,
0.012006643,
-0.00082431355,
-0.022471627,
0.0078912,
0.018382315,
0.013613625,
0.012881991,
0.013280471,
0.032191914,
-0.03786208,
-0.011157424,
-0.0039260024,
0.0037202302,
0.0126076285,
0.025162997,
0.000044731973,
0.0016853721,
-0.015769335,
0.062607,
0.01213076,
-0.014410584,
0.011634293,
0.0273579,
0.0054643946,
-0.00055852445,
0.0062156264,
0.020446569,
0.015547231,
-0.00877308,
-0.0126533555,
0.010118765,
-0.0036483733,
0.008276614,
0.010758945,
0.009354468,
-0.004644572,
-0.015586426,
-0.015847724,
0.03255773,
0.032740638,
-0.009589637,
-0.00057322247,
-0.005359875,
0.0048405454,
-0.040893137,
-0.0055591147,
-0.0042003654,
0.018891845,
-0.005095311,
-0.0018960437,
0.034883283,
-0.014763337,
-0.007551512,
0.0028220185,
-0.008635899,
0.015560295,
0.00954391,
0.0035373217,
-0.028925689,
0.017049694,
-0.0077017588,
0.0027240317,
0.0027566939,
0.0011921722,
0.022811316,
-0.023908768,
-0.030362828,
0.018852651,
-0.0061209057,
-0.019728,
0.025646398,
0.023098743,
0.024287648,
0.025280582,
-0.024548948,
0.003383809,
-0.03409939,
0.005007123,
-0.007388201,
-0.052756067,
0.018094886,
0.0017490635,
-0.023503754,
0.0053435443,
-0.0023908766,
0.006035984,
-0.010758945,
-0.024967024,
0.0391947,
0.017833589,
-0.009060509,
-0.007982654,
-0.033733573,
-0.024444427,
-0.020093815,
0.08225661,
0.024078611,
0.026456423,
0.017938107,
0.013326198,
-0.036189772,
0.03258386,
0.004820948,
0.014828661,
0.0025149933,
-0.034308426,
0.021047553,
-0.019858647,
0.0022814581,
0.014763337,
0.0019646343,
-0.018173276,
0.009315274,
-0.011640826,
0.012098097,
-0.031852227,
0.034412947,
0.026913693,
0.026704656,
-0.0036222434,
-0.023751989,
0.018173276,
-0.0070354487,
0.00423956,
-0.0076168366,
-0.006512853,
-0.0016755734,
0.0017213005,
-0.0005148387,
0.0036516394,
-0.020472698,
-0.03389035,
-0.0029951283,
0.00882534,
-0.0068133455,
0.00017800926,
0.01836925,
-0.00719876,
0.008675094,
0.000109724744,
0.014907051,
0.020459633,
-0.029526673,
-0.007721356,
0.024940895,
0.010334336,
-0.0012803602,
-0.011823734,
0.0045857797,
-0.01634419,
0.005356609,
-0.010687089,
0.009014781,
0.009040911,
-0.03140802,
0.023738923,
0.04321869,
-0.023647469,
-0.020028492,
0.0084399255,
-0.16284092,
0.014410584,
0.015442712,
0.013639756,
0.027645329,
0.009138898,
0.020106882,
0.005588511,
-0.031956747,
-0.018813455,
0.013378457,
0.0138226645,
-0.045439724,
-0.008034914,
0.00890373,
-0.0021687734,
-0.0135483015,
0.012568434,
0.0038378143,
0.025999151,
0.029213116,
-0.01639645,
0.012137292,
-0.018630547,
0.03268838,
0.033132587,
-0.004278755,
0.015560295,
0.0002110798,
-0.0217008,
-0.013260873,
0.011301138,
0.0103408685,
-0.017232602,
-0.03480489,
0.015390452,
-0.02215807,
0.003860678,
-0.017310992,
-0.0032351958,
0.021217398,
0.01944057,
-0.028925689,
0.03308033,
-0.007865069,
0.019166209,
0.014880921,
-0.015285933,
0.0062025613,
0.0015498238,
-0.004050119,
-0.0031012807,
-0.0045269877,
-0.015298998,
-0.019806389,
0.01900943,
0.020577218,
0.029134726,
-0.0050005903,
-0.031068332,
-0.009798675,
-0.036059123,
0.019179273,
-0.0076821614,
-0.0030245243,
-0.017232602,
-0.021844514,
0.0063528074,
-0.015873853,
0.0008173728,
-0.022968095,
-0.007930394,
0.012267941,
-0.0021785721,
0.012568434,
0.014240741,
-0.027148861,
-0.00638547,
0.0027517946,
-0.0007091791,
0.006022919,
0.017128084,
-0.022314848,
0.0020822184,
-0.032035135,
-0.013953313,
0.010288609,
0.0076560313,
0.0026995349,
-0.001153794,
0.04050119,
-0.027958887,
-0.00455965,
-0.021295788,
-0.0065847095,
0.0043506115,
0.012470447,
0.009792143,
-0.009922791,
-0.0038704767,
-0.008113303,
-0.012320201,
-0.030519607,
-0.0070746434,
0.0086685615,
-0.016814526,
0.0010411092,
-0.0066533005,
0.040370543,
-0.0036908342,
-0.019100884,
-0.0060915095,
-0.0014363225,
0.0022406303,
-0.011366463,
0.016788397,
-0.00137998,
-0.00060710957,
0.0048438115,
-0.01964961,
0.04721655,
-0.004399605,
-0.00285958,
-0.01631806,
0.013796534,
-0.027540809,
-0.13232131,
0.0123332655,
0.015560295,
0.009380599,
0.022027422,
-0.00551992,
-0.023830378,
0.02228872,
-0.025581075,
0.033498403,
-0.010321271,
0.005163902,
0.0074143307,
-0.023216328,
0.024980089,
0.010360465,
0.012574966,
-0.03794047,
-0.011353398,
0.029814102,
0.003952132,
-0.02359521,
0.0074012657,
0.0067153587,
-0.002918372,
0.025502685,
0.010033843,
0.03830629,
0.014907051,
0.002728931,
0.029108597,
-0.015690945,
0.0063658725,
-0.031617057,
0.010582569,
-0.02023753,
-0.0096549615,
-0.042173497,
0.025855437,
-0.02746242,
-0.0062123598,
0.004311417,
0.024091676,
0.015076894,
0.0078912,
-0.02351682,
-0.016945176,
0.02423539,
-0.0048568766,
0.006950527,
-0.029134726,
-0.023307782,
-0.004112177,
0.0025296912,
0.0018927774,
0.033263236,
-0.0030751508,
-0.003194368,
-0.016435644,
0.02351682,
0.0058694063,
0.0033446143,
-0.013443782,
0.021112878,
0.010693621,
-0.031982876,
-0.025581075,
-0.0036483733,
0.0051769665,
-0.047477845,
-0.00017800926,
0.024575077,
-0.015455777,
0.02620819,
-0.019140078,
0.014580429,
-0.021334982,
-0.00093740656,
0.009648428,
-0.025489619,
0.002599915,
-0.013202081,
0.021099813,
-0.02136111,
0.008779612,
-0.0024137404,
0.0016175979,
-0.008648964,
-0.005098577,
-0.017637614,
-0.023634404,
0.013848794,
0.028063405,
-0.021099813,
-0.0261298,
-0.0067610857,
-0.018591352,
-0.02008075,
0.023647469,
-0.023895701,
-0.015534166,
0.0008112486,
-0.014005573,
0.02743629,
-0.033210974,
-0.014410584,
-0.010896127,
0.01629193,
0.029552804,
-0.017911978,
-0.029683452,
0.014293001,
0.0036451072,
0.034726504,
-0.0103865955,
0.0029673653,
-0.025176063,
-0.011764943,
0.016644683,
0.014841726,
0.01613515,
-0.002741996,
-0.012019708,
0.00011176614,
0.02746242,
0.019427506,
-0.01716728,
-0.013901054,
-0.0037528926,
-0.0049156686,
-0.029317636,
-0.025633333,
0.008257017,
-0.010144895,
-0.010380063,
0.007303279,
0.001422441,
-0.0038084183,
0.028246313,
0.039638907,
0.018839587,
0.03527523,
-0.028167924,
-0.0021442766,
0.000029319473,
-0.02487557,
-0.009001716,
0.011405658,
-0.040788617,
0.009648428,
0.005163902,
-0.0008590172,
0.050561164,
0.008988651,
0.003687568,
-0.0066533005,
0.0057844846,
-0.030310567,
0.014580429,
0.030937683,
-0.015795464,
-0.0023255523,
0.015899984,
0.013247808,
0.0157824,
0.007982654,
-0.0047098966,
-0.001313839,
-0.015325128,
0.017925043,
0.0033576794,
0.004883006,
-0.02997088,
-0.01844764,
-0.022393238,
-0.0013113894,
0.008622834,
-0.010491115,
0.002191637,
0.01959735,
0.0065912423,
0.027828237,
-0.0009186258,
-0.006865605,
0.0072967466,
0.0001829086,
0.019610414,
0.02397409,
-0.011562437,
0.018343119,
0.016357254,
0.010393128,
-0.023987157,
0.011693086,
-0.012810134,
0.025123803,
-0.007845473,
0.019989297,
-0.009347936,
0.010014246,
0.013228212,
0.04580554,
0.0058726724,
0.012966913,
-0.0061013084,
-0.028586002,
-0.01375734,
0.00042420096,
-0.03368131,
-0.034831025,
-0.0055819787,
0.02738403,
-0.017859718,
-0.010497647,
0.008564042,
-0.011712682,
-0.029082468,
0.019832518,
0.015364323,
-0.009204222,
-0.006173165,
-0.018042628,
-0.01370508,
0.007100773,
0.027932756,
0.00751885,
0.0070354487,
-0.00023843443,
0.031982876,
-0.017363252,
0.024731856,
0.007551512,
0.018774262,
-0.0050691813,
0.016109021,
0.010053441,
-0.0064671254,
-0.005108376,
-0.0044388,
0.00077001256,
-0.02162241,
0.037208837,
0.0067022936,
0.002351682,
0.007897732,
-0.04060571,
0.033237107,
0.0047523575,
0.022301784,
0.01826473,
-0.011052906,
0.018173276,
0.01045192,
0.020812385,
-0.027331771,
-0.022994224,
0.015926113,
-0.0049287337,
0.024000222,
0.014619623,
0.0047523575,
0.046066836,
-0.0007385751,
0.029265376,
0.030807035,
-0.036268163,
-0.019963168,
-0.0011864562,
-0.0026815708,
-0.0054807253,
-0.027828237,
-0.0031143455,
0.011457917,
-0.024535881,
0.011418723,
0.012548837,
0.011209684,
-0.008727353,
-0.027619198,
0.01882652,
-0.011987045,
0.0023271854,
0.0087600155,
-0.023921832,
-0.018617483,
-0.0017278331,
-0.0042722225,
-0.02085158,
-0.008309277,
-0.04839239
] |
Although vertebrates seem to be essentially bilaterally symmetrical on the exterior, there are numerous interior left–right asymmetries in the disposition and placement of internal organs. These asymmetries are established during embryogenesis by complex epigenetic and genetic cascades. Recent studies in a range of model organisms have made important progress in understanding how this laterality information is generated and conveyed to large regions of the embryo. Both commonalities and divergences are emerging in the mechanisms that different vertebrates use in left–right axis specification. Recent evidence also provides intriguing links between the establishment of left–right asymmetries and the sym | [
-0.009061365,
0.00685,
0.007851003,
-0.020909837,
-0.02821127,
0.019653676,
-0.015204775,
-0.0107231615,
-0.012751337,
-0.025397994,
0.017193696,
0.0031534862,
0.0015383059,
0.008505253,
-0.004036724,
0.025214804,
0.043965615,
0.022859503,
0.0087865805,
-0.0024370821,
-0.007307975,
0.010278271,
0.00075729465,
-0.007438825,
0.0023487583,
0.019025596,
0.014498185,
-0.023291308,
-0.002546669,
-0.020556541,
0.003150215,
0.011887726,
-0.034596752,
-0.03389016,
0.0050638965,
0.018240497,
0.011011031,
-0.0028296323,
0.0070004775,
-0.0062088347,
0.018201241,
0.03103763,
-0.020909837,
-0.0030978748,
-0.015819771,
-0.00006297159,
-0.035826743,
-0.03375931,
-0.012967239,
0.009754871,
0.008721155,
-0.0033366762,
-0.026680324,
0.003166571,
-0.0070201047,
-0.016487105,
0.009264183,
0.021708023,
0.0113839535,
-0.038103532,
0.005629823,
-0.010245559,
-0.011540974,
0.010147421,
-0.027530849,
0.0068107448,
-0.013052292,
0.0039941976,
0.019143362,
-0.0006199021,
0.050665136,
0.008465998,
0.008243552,
0.00046574438,
0.022048233,
-0.008956686,
-0.02580363,
-0.0098202955,
-0.02988615,
-0.008361318,
-0.0040694363,
-0.02951977,
0.0023716572,
0.019889208,
0.006202292,
-0.021079943,
0.008812751,
0.014498185,
-0.01485148,
0.00716404,
-0.002839446,
0.008047278,
-0.0054466333,
-0.0020134551,
-0.004075979,
-0.020046227,
0.0053910217,
0.052183,
-0.0055578556,
-0.053046606,
-0.01438042,
0.0034053724,
-0.008727698,
-0.010016571,
-0.02729532,
0.0060387296,
0.01333362,
0.012770965,
0.02855148,
-0.0075762174,
-0.01215597,
0.005551313,
0.006617741,
-0.028420629,
0.011920439,
-0.004857808,
0.018253582,
0.023225883,
-0.017010506,
0.00739957,
0.0336808,
0.006189207,
-0.0023700215,
-0.022519292,
0.033392932,
0.013464469,
-0.02894403,
0.019248042,
-0.01602913,
-0.003964756,
0.0018793338,
-0.00031383566,
0.005786843,
0.013569149,
-0.011213849,
0.0012823305,
-0.013163514,
0.012561604,
0.009983858,
-0.035329513,
0.01304575,
0.022022063,
-0.034649093,
0.007124785,
-0.0013273101,
0.0021197707,
-0.004825095,
0.019418146,
-0.0032990568,
0.00758276,
0.0042166426,
-0.0051522204,
0.03101146,
-0.007203295,
0.0014483464,
0.022610888,
-0.014027125,
0.023736198,
0.00083048886,
-0.023539923,
-0.020464947,
0.00186952,
0.011527889,
0.005786843,
0.020046227,
0.019352721,
0.0014884192,
0.017560076,
0.00075320556,
-0.011357784,
-0.020556541,
0.003542765,
-0.036899712,
0.013817765,
-0.01804422,
0.012587775,
0.0023307665,
0.015859025,
-0.045378797,
-0.0092053,
0.00091922155,
-0.0048381803,
0.013032665,
0.0022882402,
-0.0004992747,
-0.009709073,
-0.00186952,
-0.01566275,
0.020020057,
-0.026850428,
-0.0010140878,
0.032293793,
0.0007806023,
0.017991882,
-0.63143,
-0.0050998805,
0.035931423,
-0.02996466,
0.03231996,
0.02954594,
-0.022414614,
-0.020687392,
0.0005491613,
0.0076023876,
-0.026235433,
0.0064672637,
0.017677842,
-0.029624451,
-0.017350717,
-0.008596848,
-0.00014894415,
-0.019876122,
0.01634317,
-0.00086524594,
0.007831375,
-0.0006517968,
-0.03035721,
0.02797574,
0.004583023,
0.015989875,
0.03357612,
0.00025801992,
0.013713085,
0.038967144,
-0.011711079,
0.0036147325,
-0.0289702,
-0.008793123,
0.038496085,
-0.0005037727,
-0.024050238,
0.037030563,
0.0070789875,
0.041950524,
-0.01516552,
0.0034053724,
0.016068386,
0.0036768862,
-0.03430888,
-0.0024338108,
0.030828271,
-0.002428904,
0.01783486,
-0.01678806,
-0.0032156399,
0.0028754298,
0.004638634,
-0.0081127025,
0.0066210125,
-0.0030946035,
0.0276617,
-0.0308021,
0.00034266355,
0.001511318,
-0.0126466565,
0.0010770594,
0.01589828,
-0.03014785,
0.008413658,
0.028420629,
-0.010317526,
0.008524881,
0.0014483464,
-0.017560076,
0.02585597,
0.043259025,
-0.013058835,
0.008348233,
0.007890258,
0.02860382,
0.026758835,
0.009238013,
-0.0043834765,
0.029938491,
0.008197756,
0.008923973,
-0.022074403,
-0.0037750239,
0.021236962,
-0.02904871,
0.011024117,
0.007203295,
0.02920573,
0.0018220869,
0.019993886,
-0.0063102436,
0.0013788324,
-0.044358164,
-0.025672778,
0.045876026,
-0.010651194,
0.017350717,
-0.019169532,
-0.012640114,
-0.0010999582,
-0.023487583,
0.008812751,
0.000012241635,
0.014341165,
0.014733715,
-0.03004317,
0.0006387118,
0.021171538,
-0.009264183,
0.003323591,
-0.030514231,
-0.0031518505,
0.015440306,
0.00886509,
-0.025293313,
0.0061793933,
0.007334145,
-0.0011686544,
-0.035172492,
0.011711079,
-0.0058293696,
0.0065981136,
-0.0070789875,
0.025110124,
0.038731612,
-0.0128756445,
-0.025751289,
0.0048381803,
-0.006346227,
-0.0056461794,
-0.0011539338,
0.0155580705,
-0.007916428,
0.016251575,
0.02849914,
0.037109073,
-0.002345487,
-0.023618434,
-0.019836867,
-0.011024117,
-0.03375931,
-0.011128796,
-0.020478033,
-0.031194651,
-0.017717097,
-0.016421681,
0.025018528,
-0.00080759014,
0.015832856,
-0.0014090914,
-0.008832378,
-0.02970296,
0.008223926,
0.011815759,
0.0050966092,
-0.014262655,
0.0071705827,
0.011246561,
-0.001982378,
-0.0048087393,
0.004936318,
-0.039333522,
0.003106053,
-0.024325022,
-0.021930467,
-0.006346227,
-0.03108997,
0.0044881566,
-0.030566571,
-0.0020690663,
-0.00415776,
0.0018646132,
0.009087536,
-0.0034151862,
-0.00094293815,
0.015649665,
-0.010690449,
-0.006424737,
-0.00024881953,
0.00766127,
-0.0014712452,
0.0014074558,
-0.031613372,
0.01600296,
0.015178605,
0.023827793,
0.035198662,
0.007994938,
0.034649093,
-0.00013463243,
0.013503725,
-0.01623849,
0.014053294,
0.003954943,
0.0034936962,
0.01532254,
0.021263132,
0.005940592,
0.03072359,
0.0289702,
-0.005070439,
-0.0025188634,
-0.012672827,
0.00980721,
-0.018947087,
0.00698085,
-0.006447636,
-0.019863037,
0.021132283,
0.00092331064,
-0.003088061,
0.022257593,
-0.01587211,
0.011351242,
-0.0103502385,
-0.008223926,
0.0043573063,
-0.005852268,
0.016199235,
-0.015126266,
-0.023919389,
0.008989398,
0.01506084,
-0.0055709407,
0.024115663,
-0.008145415,
0.013948615,
0.001494144,
-0.03302655,
-0.0028165472,
0.033994842,
-0.0051783905,
0.007622015,
0.017991882,
0.03559121,
-0.014629035,
-0.0043082377,
0.005341953,
0.0015137715,
0.019889208,
0.021014517,
-0.0052438155,
-0.0010320797,
0.032921873,
-0.008694986,
0.038914803,
0.0107951285,
-0.010291356,
-0.014681375,
-0.005338682,
0.0012847838,
-0.0165787,
-0.004991929,
-0.0031338586,
-0.019234957,
0.010284813,
0.004272254,
0.03496313,
0.014995415,
0.0066995225,
-0.017167525,
-0.018371345,
0.020543458,
0.017259121,
0.009166046,
-0.023238968,
0.0066111987,
-0.0035394938,
-0.0030389924,
-0.03040955,
-0.00860339,
-0.0081127025,
-0.012345701,
0.006656996,
0.002088694,
-0.011495177,
-0.0038993314,
-0.0013567514,
0.019339636,
0.0067649474,
-0.03679503,
0.02703362,
0.015728176,
-0.020307926,
-0.010566141,
-0.0017975525,
0.008825836,
0.0042166426,
0.0142103145,
0.02954594,
0.0010950513,
-0.0044718003,
-0.011246561,
-0.0038110076,
-0.0072752624,
0.008668816,
-0.0075762174,
0.0012193589,
-0.008937058,
0.012129799,
0.018083476,
-0.0046320916,
0.006526146,
0.018227411,
0.016081471,
-0.032189112,
-0.024848424,
-0.0026840616,
-0.0129149,
-0.02886552,
-0.03386399,
-0.008452913,
-0.02643171,
0.0018776981,
-0.0012921442,
-0.0025761102,
0.025306398,
0.024639063,
0.015832856,
-0.039935432,
-0.03004317,
-0.01869847,
-0.0025384908,
0.041976694,
0.030252531,
-0.02703362,
0.030017,
-0.016303916,
-0.01458978,
0.0005757402,
-0.011697994,
0.03619312,
-0.0047727553,
-0.007124785,
-0.017887201,
0.010167048,
0.003958214,
0.009486629,
0.014995415,
-0.015204775,
-0.03208443,
0.0009527519,
-0.01589828,
-0.009624021,
-0.0037292263,
0.022676313,
0.039045654,
0.011776504,
0.0038633475,
0.0047596702,
0.012476551,
-0.0028836078,
-0.006503247,
-0.015126266,
0.020674307,
-0.008825836,
0.020334097,
0.0016519818,
-0.0040694363,
0.0005221735,
0.018279752,
0.00044652578,
0.021393983,
0.021629512,
0.032869533,
0.0021917382,
-0.0068172873,
0.0071574976,
-0.01482531,
-0.0013902817,
-0.0014377149,
0.0065981136,
-0.010265186,
0.0019562081,
-0.023356734,
0.03108997,
-0.02910105,
0.025384909,
-0.005040998,
-0.0128756445,
-0.0057475884,
-0.017259121,
-0.000030693536,
0.020006971,
-0.020792073,
0.00630043,
-0.011429751,
0.0065981136,
-0.002774021,
-0.023212798,
0.008465998,
-0.037553962,
0.0011580229,
-0.013582234,
-0.01629083,
-0.021459408,
-0.03744928,
0.010487631,
0.010788586,
0.0026071873,
-0.01660487,
0.010775501,
0.011475549,
0.018646132,
-0.0026268146,
-0.012012034,
-0.023016524,
0.00721638,
0.01592445,
0.01398787,
-0.006235005,
0.009244556,
0.010559599,
0.05281108,
-0.005040998,
0.0039255014,
0.0063854824,
-0.008145415,
0.035826743,
0.022205252,
0.0258298,
-0.0020592525,
-0.014184145,
-0.0038110076,
-0.012797134,
-0.013974785,
-0.024861509,
-0.018161986,
-0.020896751,
-0.0011130432,
0.011181137,
-0.00870807,
-0.0039484003,
-0.005678892,
-0.018803151,
0.022336103,
0.0018139087,
0.008950143,
0.0025057783,
-0.013052292,
0.023775453,
0.01589828,
0.0023438514,
0.007464995,
-0.01401404,
0.025123209,
0.008328605,
-0.005521872,
0.018489111,
0.0036507163,
0.0070331898,
-0.03127316,
0.013948615,
0.03182273,
0.024429703,
0.004115234,
-0.0063265995,
-0.012123257,
0.016408596,
0.009368863,
0.010991404,
-0.021891212,
-0.019823782,
0.008459455,
0.021590257,
-0.012692454,
-0.02805425,
0.011213849,
-0.041793503,
0.0013796502,
0.021590257,
-0.0073014325,
0.02645788,
-0.009192215,
0.00360819,
0.005783572,
-0.0026938752,
0.00405308,
-0.05341299,
-0.009198758,
-0.008119245,
0.033523783,
0.020831328,
0.0008325334,
-0.004939589,
0.010068911,
0.026654154,
0.0053877505,
-0.007805205,
-0.0065425024,
-0.0041381326,
-0.01783486,
0.02925807,
0.011848471,
0.01597679,
-0.019051766,
0.0062938873,
0.037763324,
0.03504164,
-0.0031207735,
-0.01589828,
-0.01377851,
-0.026300859,
-0.017219866,
-0.0012185411,
0.005328868,
0.001882605,
-0.02946743,
-0.0019856493,
0.0071117,
-0.006022373,
-0.0040170965,
-0.021236962,
0.031613372,
-0.012018576,
0.036062274,
-0.018397516,
0.01440659,
-0.021616427,
-0.007883715,
-0.0046648043,
-0.024455873,
0.004481614,
-0.022728654,
0.012129799,
0.03014785,
-0.018083476,
0.019562082,
-0.0056200093,
-0.011102626,
0.013529895,
-0.018881662,
-0.011737249,
-0.00870807,
-0.0024010984,
-0.011691451,
-0.026876599,
-0.011508262,
-0.0108670965,
-0.02617001,
0.025031613,
-0.0064934334,
-0.035198662,
0.015204775,
-0.01584594,
0.03069742,
-0.0151131805,
0.013412129,
0.0137654245,
0.00067469553,
-0.020674307,
-0.021367813,
-0.017141355,
0.00622192,
0.024141833,
-0.0032990568,
0.0018482569,
-0.0276617,
0.025594268,
0.0075762174,
-0.027242979,
-0.041872013,
0.00026538025,
-0.001594735,
-0.0075107925,
-0.0037684813,
0.0017762893,
-0.010140878,
0.0040727076,
-0.036559504,
0.007883715,
-0.020595796,
-0.02972913,
0.0072883475,
0.009859551,
-0.002860709,
0.03245081,
0.0017141356,
0.010710076,
0.006758405,
0.010768958,
-0.024704488,
0.004782569,
0.023723112,
0.0052176453,
-0.012463467,
0.01521786,
0.011298901,
0.014707545,
-0.006503247,
-0.016709551,
-0.022780992,
0.0373446,
-0.033523783,
-0.00813233,
-0.00060518144,
0.0029523042,
0.0107951285,
-0.010219389,
-0.003043899,
-0.01932655,
-0.026248518,
0.008498711,
0.02784489,
0.025371823,
0.0145112695,
-0.015021585,
-0.016356256,
-0.01545339,
-0.03300038,
-0.021315472,
-0.008524881,
-0.009388491,
0.014916905,
0.0104222065,
0.00013902817,
0.0021950095,
0.0077070678,
-0.032895703,
-0.021851957,
0.02868233,
-0.003568935,
0.014393505,
0.018554537,
0.005050812,
-0.04922579,
-0.0064934334,
-0.010330611,
-0.01723295,
0.021668768,
-0.015073925,
-0.011737249,
0.0006767401,
0.004455444,
0.00873424,
-0.0027887416,
0.0044063753,
-0.016513275,
-0.006447636,
0.01568892,
-0.015571156,
-0.038234383,
0.016133811,
0.00773978,
-0.03074976,
0.0048774355,
-0.022218337,
0.009983858,
-0.025306398,
-0.003964756,
-0.0008816022,
-0.012489636,
-0.013896274,
-0.0064967046,
0.03072359,
-0.0077332375,
-0.01508701,
-0.020517288,
-0.020281756,
-0.026850428,
-0.00086115685,
-0.0033890163,
-0.025620438,
0.0076285577,
0.008616475,
0.019784527,
-0.0062971585,
0.012790591,
-0.01652636,
0.010239016,
-0.009041738,
-0.045352627,
-0.0035133236,
-0.016827315,
0.026641069,
0.031142311,
-0.010834384,
0.009702531,
-0.0026219077,
-0.02551576,
-0.012921442,
0.018332092,
0.020307926,
0.025921393,
0.025869055,
0.015440306,
0.0013125895,
-0.0048087393,
0.0042918813,
0.016735721,
-0.018855492,
0.014184145,
-0.0028737942,
0.016460937,
0.01571509,
-0.02802808,
-0.03190124,
0.017612416,
-0.017062847,
-0.010880182,
0.000101153215,
-0.00007068969,
0.023958644,
-0.011743791,
0.021485578,
0.01260086,
0.017847946,
0.016931996,
-0.011410124,
-0.0021377625,
-0.0042918813,
-0.0046059215,
-0.024141833,
-0.0040072827,
0.005943863,
0.015047755,
0.011835387,
-0.0318489,
0.004897063,
0.004334408,
-0.010016571,
0.020438777,
0.021485578,
0.011606399,
0.011828844,
0.014445845,
0.0036245463,
-0.0067976597,
-0.017638586,
-0.01571509,
0.021053772,
-0.015440306,
-0.004556853,
0.014184145,
-0.0025090496,
-0.0053354106,
-0.02938892,
0.0043082377,
-0.024560554,
0.0071771247,
-0.017507736,
0.05851614,
-0.0019938275,
-0.0031485793,
0.011122254,
-0.0036768862,
-0.026641069,
-0.023160458,
-0.022938013,
0.0065621296,
0.01712827,
0.0031911056,
-0.012077459,
-0.020831328,
-0.019679846,
0.006993935,
-0.0014916905,
-0.03436122,
0.009264183,
0.16947697,
-0.027164469,
0.011979322,
-0.018188156,
-0.0038862464,
-0.040589683,
0.019941546,
-0.0020690663,
0.004690974,
-0.010651194,
-0.009767956,
0.00726872,
-0.01678806,
0.006565401,
0.044122636,
-0.02828978,
-0.043285195,
0.011933524,
0.0034282713,
0.0014221764,
-0.022231422,
-0.028132759,
-0.006804202,
-0.023736198,
0.037553962,
0.0042101,
-0.046504106,
0.008328605,
-0.004923233,
0.013791595,
-0.0037423114,
0.0014573424,
0.019405061,
0.002599009,
-0.014288825,
-0.010153963,
-0.0062186485,
0.012640114,
0.020778988,
-0.004481614,
0.0034871537,
0.019902293,
0.048205156,
-0.021079943,
-0.0011433023,
0.020582711,
0.01445893,
-0.011292359,
0.0037423114,
0.010808214,
-0.03294804,
0.020661222,
0.040249474,
0.028132759,
-0.018057305,
0.0020150908,
0.023068862,
-0.007150955,
0.01634317,
0.03320974,
-0.0113839535,
0.0038600764,
-0.034675263,
0.021433238,
0.002677519,
0.03247698,
0.0046942453,
0.00745191,
0.015832856,
-0.034544412,
0.016225405,
-0.02695511,
-0.037737153,
0.0047236867,
-0.015728176,
-0.01595062,
0.03061891,
0.010782043,
0.010140878,
0.015675835,
-0.0013812858,
0.008544508,
-0.035146322,
-0.000104475585,
-0.009067908,
-0.024678318,
0.021040687,
0.017167525,
0.00444563,
0.010945606,
-0.006264446,
-0.03231996,
-0.0016765161,
-0.012659742,
0.03305272,
-0.021407068,
0.0051882043,
0.005979847,
-0.02836829,
-0.00097401504,
-0.019261127,
0.039385863,
0.03318357,
-0.0033170485,
-0.0060256445,
0.021040687,
0.010468003,
0.03234613,
0.008884718,
-0.009741786,
-0.0012226301,
-0.008073448,
0.0016928725,
0.00415776,
0.020582711,
0.019928461,
0.01385702,
-0.022113658,
0.025882138,
0.005482617,
-0.012901815,
-0.0104941735,
0.016709551,
0.03030487,
0.011331614,
-0.040223304,
-0.042238396,
0.010448376,
0.0023880133,
-0.035905253,
-0.0021966451,
0.0025875596,
0.0015996417,
0.013235482,
-0.0075762174,
-0.019091021,
0.014157975,
-0.015544985,
-0.03137784,
0.00048332734,
-0.014838395,
0.014576695,
0.015793601,
-0.005518601,
0.03067125,
-0.021014517,
0.004200286,
0.012633571,
-0.013104632,
-0.009480086,
-0.043991785,
-0.0061957496,
-0.0005761491,
-0.0054793456,
0.015859025,
-0.024403533,
-0.024482043,
-0.046294745,
0.0024550739,
0.015466475,
-0.02648405,
0.022179082,
0.023081947,
-0.025358738,
0.004543768,
0.00050908845,
-0.16298681,
-0.00826318,
0.02695511,
-0.03200592,
0.017625501,
0.012594317,
0.013372875,
-0.00036760684,
0.005963491,
0.011442836,
0.040249474,
0.014576695,
-0.031194651,
-0.03140401,
0.0015268564,
0.010369866,
-0.010821299,
0.03072359,
0.0040040114,
0.013595319,
0.032634,
-0.03438739,
0.038391404,
0.0014213587,
0.011809217,
0.0281851,
-0.0027004178,
0.0011171323,
0.007203295,
-0.03004317,
0.0021148638,
0.0023716572,
0.03197975,
0.0055807545,
0.01469446,
-0.0002809187,
-0.0052896133,
-0.0064018383,
-0.01443276,
0.01490382,
0.0010042741,
0.03069742,
0.000021544256,
-0.011711079,
0.004560124,
0.011586771,
-0.01718061,
-0.022126742,
0.021917382,
-0.018476026,
0.0024403534,
-0.006555587,
-0.008511796,
-0.0152571155,
0.022689398,
0.010736247,
0.008596848,
0.02679809,
-0.0020903295,
-0.028132759,
0.012332616,
-0.021838872,
0.03433505,
-0.0017795606,
0.013340162,
-0.012555062,
-0.0186723,
-0.0026987821,
-0.038836293,
-0.013425214,
0.003027543,
-0.013156972,
-0.0010067276,
-0.027818719,
0.049513657,
-0.014786055,
-0.010513801,
0.0055284146,
0.005999475,
-0.0062709884,
-0.008145415,
-0.0042428127,
-0.03491079,
0.0032254537,
-0.0067649474,
-0.0129149,
-0.025712034,
0.0024877866,
0.01838443,
0.0021312202,
0.037318435,
-0.042133715,
-0.020163992,
-0.015911365,
0.0024403534,
0.024874594,
0.0046288203,
-0.018554537,
0.011920439,
0.008308978,
0.00376521,
-0.0069088824,
-0.019391976,
0.037894174,
0.016931996,
0.008544508,
-0.020255586,
0.0019382163,
0.050586626,
0.0014295367,
-0.008937058,
0.007988395,
-0.012332616,
0.01715444,
-0.0108670965,
0.022676313,
0.002926134,
-0.0023814708,
0.0018106375,
-0.03129933,
0.049618337,
0.0051685767,
-0.0016994149,
0.017075932,
0.014027125,
-0.026824258,
-0.1232084,
-0.03493696,
0.0067649474,
0.027792549,
-0.011462464,
0.021629512,
-0.019418146,
0.012941069,
0.002949033,
0.036611844,
-0.036559504,
-0.034727603,
-0.021668768,
-0.03506781,
-0.004883978,
0.010127793,
-0.0082566375,
-0.015230945,
-0.0018417144,
0.015623495,
0.0005434366,
-0.03137784,
-0.007785578,
-0.017586246,
-0.01469446,
-0.000983011,
-0.024338108,
0.02522789,
0.016696466,
-0.021014517,
0.01930038,
-0.013196227,
-0.009879178,
-0.012810219,
-0.004390019,
-0.0047760266,
-0.0001614158,
-0.026287774,
0.0096763605,
-0.013412129,
-0.010664279,
0.004324594,
0.03040955,
-0.013556065,
-0.0029719316,
-0.011874641,
-0.0297553,
0.0063167857,
0.01540105,
-0.012823304,
-0.005273257,
-0.03035721,
-0.019692931,
-0.004324594,
0.021433238,
-0.0073014325,
-0.004255898,
0.03797268,
-0.0020281756,
0.010827841,
0.005286342,
0.008178128,
-0.00025086408,
0.026353199,
0.0032074617,
-0.012038204,
-0.024992358,
-0.014236485,
0.020386437,
-0.053700857,
0.0043573063,
0.025999904,
0.01615998,
0.0048283665,
-0.03386399,
0.009669818,
-0.005718147,
0.023945559,
0.005430277,
-0.02999083,
-0.005754131,
-0.0150085,
0.026104584,
-0.026850428,
0.02954594,
0.022702483,
0.017690927,
-0.0068630846,
0.00792297,
0.0000093473445,
-0.016460937,
0.037527792,
0.01532254,
-0.051816616,
-0.01338596,
-0.009080993,
0.01307192,
-0.021446323,
0.0015399414,
0.00792297,
-0.015728176,
0.0061532236,
-0.038810123,
0.013883189,
-0.0045797518,
-0.01199895,
0.008210841,
0.012960697,
0.026824258,
-0.010984861,
0.007464995,
0.026824258,
-0.023906304,
0.017285291,
-0.0065882998,
-0.024534384,
-0.026510218,
-0.0239979,
0.019666761,
0.03328825,
0.02800191,
0.025934478,
0.0132485675,
-0.00058718957,
0.019836867,
0.013078462,
-0.029624451,
-0.011063371,
-0.01898634,
-0.007641643,
-0.018371345,
-0.0032925142,
0.008649188,
-0.02494002,
0.0018809694,
0.025463419,
0.00057982927,
0.0011408488,
0.003997469,
0.02805425,
0.019483572,
0.040170964,
-0.007988395,
-0.03046189,
0.031587202,
-0.008668816,
0.002957211,
0.019849952,
-0.010657736,
0.0077463225,
-0.0030308142,
-0.01349064,
0.009741786,
0.0118419295,
0.0016315365,
-0.0308021,
-0.010343696,
-0.009532426,
0.002917956,
0.001035351,
0.0008313067,
-0.022440782,
0.033942502,
0.0184106,
0.008361318,
-0.03383782,
-0.011848471,
-0.010186676,
-0.01320277,
-0.00713787,
0.00084970746,
-0.038286723,
-0.03250315,
0.012528892,
0.017376887,
0.014040209,
-0.0019529369,
0.0020739732,
-0.008328605,
0.037030563,
-0.02802808,
0.021865042,
0.0067322347,
0.021616427,
-0.009512798,
0.008014565,
0.041165423,
-0.01477297,
-0.025725119,
0.022375358,
-0.020229418,
0.004334408,
-0.00698085,
0.014197229,
0.0029588467,
0.019535912,
-0.0029375835,
0.008250095,
-0.012842932,
0.01576743,
-0.011423209,
0.012496179,
0.011855014,
0.016068386,
0.021498661,
-0.020451862,
-0.0048316377,
-0.0040956065,
-0.023553008,
-0.035172492,
0.0032418098,
-0.008995941,
-0.0030406278,
0.008609933,
-0.000042398482,
-0.0036278174,
-0.004740043,
0.014184145,
-0.00001098297,
-0.023723112,
-0.004154489,
0.008073448,
0.0258298,
0.02912722,
-0.010598853,
-0.010755873,
0.013634575,
-0.0011735613,
0.048911747,
-0.00760893,
0.011455921,
0.010945606,
0.019836867,
0.010042741,
-0.006264446,
-0.015911365,
-0.006656996,
-0.01561041,
-0.0060943407,
0.0017239493,
-0.0118419295,
0.06249398,
-0.014288825,
0.00873424,
0.03616695,
-0.02708596,
0.034073353,
0.008590305,
0.025306398,
0.0022833333,
-0.03101146,
0.01681423,
-0.0071051572,
0.01615998,
-0.0128756445,
-0.012941069,
0.01385702,
-0.03608844,
-0.0000591892,
0.0022686126,
-0.012103629,
0.0071051572,
-0.021223877,
0.026248518,
0.00753042,
-0.029938491,
0.0047302293,
0.008969771,
0.008230468,
-0.0092053,
0.023173543,
0.008335148,
0.0056985193,
-0.0663148,
-0.0052536293,
-0.0031436724,
0.011534431,
0.005705062,
-0.034701433,
0.0050966092,
0.015885195,
0.0024730659,
0.0018629775,
-0.0043965615,
-0.020765902,
-0.01503467,
-0.01838443,
-0.0075565903,
-0.0017599331,
-0.050717477
] |
Epidemiological studies suggest a positive association between obesity and type 2 diabetes mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance, hyperinsulinemia, increased levels of IGF, elevated levels of steroid and peptide hormones, and inflammatory markers appear to play a role in the connection between these different diseases. Medications, such as metformin and exogenous insulin, used to treat T2D may affect the risk of cancer and cancer-related mortality. Newer therapies targeting the insulin and IGF1 systems are being developed for use in cancer therapy. | [
-0.016395606,
-0.038341675,
0.008121069,
-0.022623891,
-0.008536714,
-0.0010391132,
-0.022304164,
-0.0011022593,
-0.0044985604,
-0.009828411,
0.020206753,
0.007347329,
0.007360118,
0.0106085455,
-0.014067993,
0.016792068,
0.067372896,
-0.0069508674,
0.011158477,
-0.009093039,
-0.03547692,
0.0060428423,
0.0010942661,
-0.0014331768,
-0.005895768,
0.01914526,
-0.004776723,
-0.04082276,
-0.002724075,
-0.018595329,
0.017610569,
-0.0033795156,
-0.019720769,
-0.00103112,
-0.006269849,
-0.0006154747,
0.0022173075,
0.00095918134,
0.011554938,
-0.030233396,
0.0074816146,
-0.0017233292,
-0.0052179466,
0.00031513104,
-0.0080635175,
0.017700093,
0.031333257,
-0.017815195,
-0.0053522317,
0.011548543,
-0.002105403,
0.025450278,
-0.030796116,
-0.020475324,
0.0016657782,
0.00893957,
-0.0064169234,
0.023327291,
0.0091889575,
-0.021818178,
0.00220292,
-0.0087669175,
-0.022841305,
-0.0008584673,
-0.006733453,
0.0042427788,
0.004597676,
0.016510708,
0.008479163,
0.021715866,
0.016664177,
0.04749866,
0.00051356165,
0.0011110518,
0.0149248615,
-0.020142809,
-0.020833418,
0.010096982,
0.023186611,
-0.0024555041,
0.017891929,
-0.028187143,
-0.007027602,
0.031895977,
0.013978469,
0.006391345,
-0.015436425,
0.013607586,
0.005173185,
-0.014042415,
-0.009822017,
0.0055728434,
0.0035169981,
0.027112858,
0.01717574,
0.01856975,
-0.0053202594,
0.025821162,
0.0038942762,
-0.0064009367,
-0.004108493,
0.03309815,
-0.00047279647,
-0.019899815,
-0.004942981,
0.011203238,
0.00171054,
0.006199509,
0.0101929,
-0.017508257,
-0.0016481932,
0.059136726,
-0.0030821695,
-0.021894913,
-0.0028327822,
0.005045294,
0.01676649,
0.010857933,
-0.010244057,
-0.011222422,
0.006886922,
0.014310986,
0.021383349,
-0.0099051455,
-0.007360118,
-0.008223381,
-0.020500902,
-0.0067526367,
-0.010429499,
-0.013492485,
0.021958858,
0.0031557067,
0.0061259717,
-0.011913032,
-0.020999677,
0.016856013,
-0.029261425,
-0.020513691,
-0.011222422,
-0.032279648,
-0.008997121,
0.02291804,
-0.004754342,
0.011510176,
-0.022125116,
0.023774909,
0.027573267,
0.0054385583,
-0.00041564525,
-0.0055504628,
-0.003408291,
-0.019950971,
0.01236065,
-0.012929765,
0.030079927,
-0.00881168,
-0.002570606,
0.023007562,
-0.020014917,
-0.019464986,
0.009694126,
-0.011753169,
-0.018045397,
0.023634229,
0.010435893,
0.0065608,
-0.003106149,
-0.015743364,
-0.016868802,
0.00042523706,
0.0067654257,
0.0298753,
-0.01341575,
0.028161565,
-0.0011789937,
0.021460084,
-0.026575718,
0.022048382,
-0.008664605,
-0.026089732,
-0.017700093,
0.036679093,
0.022406476,
0.010985823,
-0.033712026,
-0.00009616792,
0.005486517,
-0.00349142,
-0.0010982626,
-0.038878817,
0.0125908535,
0.016983904,
0.0042587654,
-0.024746878,
-0.6441606,
-0.0240179,
0.022189062,
-0.0072322274,
0.0022205047,
0.024056269,
0.008332089,
0.020168386,
-0.020091651,
0.005205157,
-0.0024251302,
0.023698173,
-0.006688691,
-0.018505806,
0.005134817,
-0.03309815,
-0.005467334,
-0.03440264,
-0.002140573,
-0.016331661,
-0.0081338575,
0.016459553,
-0.0044506015,
0.00057430984,
0.002386763,
0.022086749,
0.0041372688,
-0.019042946,
0.020999677,
0.046654582,
-0.022521578,
0.021587975,
0.013530851,
-0.0069188946,
0.044915266,
-0.0064105284,
0.0076158997,
0.011574121,
0.0113822855,
0.030386865,
-0.013159968,
0.004645635,
0.022866882,
0.02137056,
-0.019925393,
0.019401042,
0.020347433,
0.01997655,
0.027726736,
0.0019311517,
0.01368432,
0.031051897,
-0.039748475,
-0.034146857,
0.032075025,
-0.014221462,
0.027266327,
-0.03826494,
0.0030054348,
0.007724607,
0.0084855575,
0.028596394,
-0.019221993,
-0.0053042728,
-0.012533302,
0.018518595,
-0.017687304,
0.015052753,
-0.0006270648,
0.01550037,
0.0268315,
0.036141954,
0.0013300648,
0.02877544,
0.040055413,
0.0318704,
0.022380898,
0.033405088,
-0.016894381,
0.005211552,
0.0039230515,
0.0020558452,
-0.019030157,
-0.004006181,
0.0019966958,
0.0038591062,
0.011708407,
0.010218479,
-0.0074624307,
-0.0060204617,
0.01997655,
-0.0054193744,
-0.030642647,
-0.026396671,
-0.014605135,
0.027291907,
-0.01607588,
0.010781198,
0.023097087,
-0.00908025,
-0.019669613,
-0.010672491,
-0.021664709,
0.003048598,
0.014976018,
-0.0068485546,
-0.02514334,
0.012578065,
0.029849723,
-0.008127463,
0.014349353,
0.0024267288,
0.00090562704,
0.0017249278,
0.024401573,
-0.009176169,
0.004543322,
0.0045593088,
0.0052147494,
-0.0149248615,
0.0061195767,
0.010813171,
-0.0035074065,
-0.009163379,
-0.0011414258,
0.022866882,
-0.0019359477,
-0.0053138644,
-0.0061899167,
-0.04289459,
0.008607054,
0.0070339963,
0.008312905,
-0.0016114246,
0.0078524975,
-0.013313437,
-0.0020830221,
0.002417137,
0.000055003056,
-0.031998288,
-0.022086749,
-0.003149312,
0.010934668,
-0.0067526367,
0.010371948,
-0.008747734,
-0.004022167,
-0.0011678033,
0.02193328,
-0.0019807094,
-0.006074815,
-0.015103909,
-0.015628261,
0.014170306,
0.019669613,
-0.009476712,
0.013940102,
-0.011970583,
0.000056751564,
0.0101865055,
0.011644461,
0.005467334,
-0.005502504,
-0.021958858,
-0.025463067,
-0.04650111,
-0.003101353,
0.020500902,
-0.019541722,
-0.020731106,
-0.006388148,
-0.040873915,
0.0060428423,
0.017994242,
0.009029094,
0.028187143,
-0.0073409346,
-0.008421612,
-0.01535969,
-0.0034754337,
0.010992218,
0.007679845,
-0.028110407,
0.008882019,
0.04161568,
-0.014553978,
0.013940102,
-0.0035585628,
-0.0059725023,
0.04340615,
-0.056476597,
0.04274112,
0.008216986,
0.017521046,
0.012769901,
-0.015334113,
-0.00040185702,
0.00022001223,
-0.010589362,
-0.00027856225,
0.022981985,
-0.036704674,
-0.00045521147,
-0.023685385,
0.021613553,
-0.015986355,
0.0030869653,
-0.0085558975,
0.020897364,
0.010423104,
-0.0039038681,
0.012405412,
-0.0069508674,
0.0044825743,
-0.003246829,
0.010787593,
0.0050165183,
-0.020577637,
-0.0052882866,
-0.014157517,
-0.018352337,
-0.002829585,
0.024759667,
-0.031026319,
-0.000978365,
0.0121688135,
0.024759667,
0.0038175418,
-0.02724075,
-0.024682933,
-0.012456568,
0.0034882228,
0.011260789,
0.003830331,
0.012578065,
0.008191409,
0.0067782146,
-0.019477775,
0.030131083,
0.015615473,
0.01748268,
-0.007449642,
0.01984866,
0.003929446,
-0.0018720023,
-0.011088137,
0.039185755,
0.021920491,
-0.012335072,
0.006439304,
0.002912714,
-0.00544815,
0.0014579557,
-0.009246508,
-0.007820525,
-0.006352978,
0.01082596,
0.0016785674,
0.040285617,
0.009649364,
0.014170306,
-0.015807308,
-0.0022332938,
0.021319404,
-0.0036289028,
0.012347861,
0.019337095,
-0.003289992,
0.008434401,
0.010953851,
-0.0405414,
0.0059629106,
0.014259829,
-0.0153469015,
0.010461471,
0.019912604,
0.0052978783,
-0.01179793,
0.027164016,
0.010288819,
0.014605135,
-0.025309598,
0.02652456,
0.010033037,
-0.0042044115,
-0.021217091,
-0.021626342,
0.007328145,
0.015692206,
0.026498983,
0.021076411,
0.032586586,
0.013441328,
0.0067526367,
-0.0038718954,
0.00872855,
-0.00037168278,
-0.007360118,
0.02765,
0.013978469,
0.019401042,
0.019759135,
0.0031285298,
0.0111009255,
0.024324838,
-0.0028855372,
0.011612489,
-0.0030406048,
-0.023084298,
-0.024005111,
0.0019023763,
-0.016536286,
-0.00838964,
0.00558883,
0.022393687,
0.014720236,
0.00046120636,
0.0012589255,
-0.0021725458,
-0.013198336,
-0.016408395,
-0.014272618,
-0.004578492,
-0.0036864537,
0.034070123,
0.018493015,
0.0037344126,
0.004022167,
0.013633164,
0.020539269,
-0.0027576464,
-0.030949585,
0.013940102,
0.011279972,
0.005381007,
0.011612489,
0.019324306,
-0.0028151972,
0.002767238,
-0.010806777,
-0.012597248,
-0.036551204,
0.0008480762,
0.000036368958,
0.001061494,
-0.009527868,
0.034811888,
0.035809435,
0.058829788,
-0.031998288,
-0.00022141103,
0.03788127,
-0.020449746,
-0.007206649,
-0.0023851644,
0.016011935,
-0.0041180854,
0.046322063,
-0.016127035,
-0.023071509,
0.018927844,
0.010384737,
0.022828516,
-0.0070339963,
0.008082702,
0.019030157,
0.021843756,
0.007398485,
-0.009917935,
-0.0136459535,
-0.014195884,
0.022687836,
0.0021869335,
-0.0013292654,
0.015525948,
0.001577054,
-0.0072194384,
-0.03744644,
-0.00078213244,
-0.00035989285,
0.0005275497,
-0.0262432,
-0.024772456,
0.0106788855,
0.015014385,
-0.0025738033,
0.018787164,
-0.018799955,
-0.01172759,
0.020475324,
-0.012578065,
-0.016523497,
-0.001491527,
0.0030981558,
0.05320259,
-0.025923474,
0.008760523,
0.013051261,
-0.001305286,
0.0074112746,
0.0019215599,
-0.0057614828,
0.0004883832,
0.012156025,
-0.0036480865,
0.018927844,
0.0014779386,
-0.0326889,
0.00893957,
-0.00719386,
-0.019797502,
-0.01479697,
-0.020577637,
0.0101161655,
-0.01243099,
-0.019401042,
0.016293293,
-0.012744322,
0.000019445903,
-0.010864328,
-0.0023036338,
0.009892357,
0.0053490344,
-0.0131216,
-0.00335074,
-0.017853562,
-0.028263876,
-0.0188639,
-0.0040125754,
-0.015704995,
0.01061494,
0.002394756,
0.008408823,
-0.018825533,
0.011235211,
-0.018262813,
0.016702544,
0.0013492485,
0.020974098,
0.03130768,
-0.008159436,
0.0007117925,
0.00028995253,
-0.0052627083,
-0.029645098,
0.0035809437,
-0.00008512734,
-0.020577637,
-0.018620906,
-0.009348821,
-0.004786315,
-0.0166386,
-0.030642647,
-0.00094958954,
0.0021565594,
0.035860594,
-0.0150655415,
-0.024081847,
-0.03309815,
-0.0021070016,
-0.0079931775,
-0.010934668,
-0.011164871,
-0.013582008,
-0.033046994,
-0.0041564526,
0.017290842,
-0.041641258,
0.042024933,
-0.031230945,
-0.009732493,
0.014733026,
0.009323243,
0.01507833,
0.006062026,
0.0038143445,
-0.03759991,
0.01179793,
-0.015167854,
-0.004293935,
0.0015322922,
0.00046440362,
0.03381434,
0.057908975,
0.016114246,
0.0130128935,
0.032765634,
-0.0009072257,
0.013466906,
0.023467971,
-0.006164339,
0.0048886277,
-0.010512628,
0.009809228,
-0.012891397,
0.000565917,
0.011254394,
0.0049461783,
0.012424596,
-0.012718745,
-0.013159968,
-0.018902266,
-0.021306615,
-0.032944683,
-0.02486198,
0.0044506015,
-0.0026745172,
0.0040637315,
-0.029287003,
-0.021549607,
0.010391131,
0.012821057,
0.009214535,
-0.0039198543,
0.008856441,
-0.015820097,
0.037062768,
0.0074432474,
-0.021549607,
-0.019682402,
-0.0128018735,
0.00013478496,
-0.021524029,
0.020705529,
-0.00860066,
-0.0009391984,
-0.012104869,
-0.011855481,
0.0020558452,
0.015704995,
-0.033405088,
0.007916443,
0.0023579875,
-0.025936263,
0.0016114246,
-0.017278053,
-0.024363207,
-0.015449214,
-0.0146435015,
0.010058615,
-0.026064154,
0.009719704,
0.000048883277,
-0.0153469015,
-0.00080051675,
-0.012648405,
-0.005205157,
-0.00971331,
0.01327507,
0.016613021,
0.000735772,
0.001287701,
-0.00093839905,
0.006995629,
-0.008945964,
0.023698173,
0.010499839,
0.018787164,
-0.014004048,
0.012092079,
0.009515079,
-0.0067398474,
-0.030386865,
0.01368432,
-0.0071618874,
-0.0031477134,
-0.01493765,
-0.021076411,
-0.03726739,
-0.004303527,
-0.010237662,
0.00213258,
-0.013952891,
-0.013582008,
-0.012181603,
0.033686448,
-0.015449214,
0.008990726,
0.00419482,
-0.01998934,
-0.0030517953,
-0.03982521,
-0.010026642,
-0.006899711,
0.011772352,
0.019158049,
-0.00037488004,
0.0044633904,
0.024005111,
-0.0133645935,
0.0018799955,
0.016613021,
-0.021127567,
0.0340957,
0.012859425,
0.010851538,
0.00338591,
-0.03348182,
-0.00096477655,
0.0078524975,
-0.0045529143,
0.0014755406,
-0.041411057,
-0.008549503,
0.017214108,
0.022457633,
-0.014490033,
0.012584459,
-0.033993386,
-0.0075455597,
-0.01899179,
-0.02025791,
0.0039582215,
-0.025885107,
-0.013236702,
-0.021690287,
-0.012335072,
0.016587442,
0.010033037,
0.015308534,
0.005790258,
0.03043802,
-0.027010547,
0.019068524,
0.0108195655,
0.01278269,
0.015577105,
-0.0006790205,
-0.03422359,
-0.027215172,
0.0010878715,
0.016983904,
-0.031051897,
-0.022265796,
0.007430458,
-0.011490992,
0.011650856,
-0.0061035906,
0.027215172,
0.0217926,
0.018672064,
-0.015129487,
-0.036423314,
0.031768087,
-0.021357771,
0.0016689756,
0.017533835,
0.0076734507,
-0.0038431198,
-0.005045294,
0.0020030905,
-0.0072705946,
0.013914524,
-0.014055204,
-0.033200465,
0.028289454,
-0.008786101,
0.0233145,
-0.0023627833,
0.006273046,
-0.012060107,
0.022841305,
0.004997335,
0.010851538,
-0.029696254,
0.0018000636,
-0.0067526367,
0.021076411,
-0.023544705,
-0.036397733,
-0.02359586,
-0.0025338375,
-0.032842368,
0.003974208,
-0.018531384,
0.012948948,
0.0037120318,
-0.005205157,
-0.030361287,
-0.0023404025,
-0.011746774,
-0.0013948096,
0.00024379192,
0.020373011,
0.0020062877,
0.007858892,
-0.024209738,
0.034300324,
0.016932748,
0.007468825,
-0.02571885,
-0.00950229,
-0.001597037,
-0.004703186,
0.023902798,
-0.0019007777,
-0.021997225,
-0.02431205,
0.037088346,
-0.026396671,
0.010704463,
0.0016881592,
-0.011017797,
0.01250133,
-0.018237235,
0.00048958213,
0.0052786944,
0.0017920705,
0.004293935,
-0.014016837,
-0.008472769,
0.01758499,
-0.0036001273,
0.01607588,
-0.030463599,
-0.006247468,
-0.0029494825,
0.011184054,
-0.0015642649,
-0.020462535,
-0.0021453688,
-0.01158691,
0.0012397419,
0.0006934082,
0.021997225,
-0.016561864,
-0.009214535,
-0.0039326437,
-0.013185546,
0.0010990619,
0.0017377168,
-0.007360118,
0.0054289666,
0.0066759023,
-0.034939777,
0.006234679,
0.021127567,
-0.011414258,
0.008332089,
0.0022956408,
-0.025514223,
-0.023813276,
0.012673982,
-0.010582968,
-0.025194496,
-0.028289454,
0.01193861,
-0.0076670563,
-0.008843652,
-0.014221462,
0.010666097,
-0.00698284,
-0.022828516,
-0.012130447,
-0.0023579875,
0.02695939,
-0.030693803,
-0.022470422,
-0.03478631,
0.012929765,
0.18590213,
-0.020219542,
-0.0052659055,
0.019349884,
-0.00422999,
0.014144727,
0.020769473,
-0.0017409142,
-0.0019311517,
0.002943088,
0.012277521,
-0.009764466,
-0.010838749,
-0.000087775086,
0.005592027,
0.0114526255,
-0.031921554,
0.0041724388,
0.015692206,
-0.010704463,
-0.006861344,
-0.0071810707,
0.0035457737,
-0.008786101,
0.021639131,
0.015679417,
-0.011561332,
-0.004041351,
0.032791212,
-0.003584141,
-0.020718317,
0.001697751,
0.004038153,
0.023647018,
0.00684216,
0.0028839386,
-0.0072130435,
-0.019439409,
0.011478203,
-0.023097087,
0.005988489,
-0.0061131823,
-0.031026319,
-0.022406476,
0.007660662,
-0.009604602,
-0.01983587,
0.0053362455,
0.00860066,
-0.011267183,
-0.02977299,
-0.029798567,
0.033865497,
0.003158904,
0.022559945,
0.011196843,
0.030770537,
-0.019477775,
-0.0016258124,
0.004092507,
0.004636043,
0.0020462535,
-0.0130128935,
0.025757216,
-0.03716508,
0.030233396,
-0.031921554,
0.0061835223,
0.0014787379,
0.0013676328,
0.0054769255,
-0.01075562,
-0.018186077,
-0.0029207072,
0.0029095167,
0.00394863,
0.014055204,
-0.00016775682,
0.0027704355,
0.008543109,
-0.0069061057,
0.019656822,
-0.00024359209,
-0.0038111473,
-0.011702012,
-0.034837466,
0.025322387,
-0.014515611,
-0.012488541,
0.0046168594,
-0.006618351,
0.017853562,
-0.016178193,
0.0004472183,
0.0061227744,
-0.017469889,
-0.024005111,
0.0005387402,
-0.006106788,
-0.031333257,
-0.03496536,
0.08589149,
0.003048598,
0.0002817595,
-0.016996693,
-0.0010998612,
-0.02415858,
-0.0020478521,
0.02486198,
0.0036736645,
0.0068101874,
-0.030847272,
0.0035106037,
-0.025066605,
-0.00090562704,
0.008997121,
0.011535754,
-0.014912073,
-0.016024724,
-0.02403069,
0.008594265,
-0.0357327,
0.0069061057,
0.024695722,
-0.012840241,
0.01998934,
-0.004706383,
-0.0067654257,
-0.00090083113,
-0.035502497,
0.0074944035,
-0.031895977,
-0.008504741,
0.013658742,
0.015129487,
-0.021012466,
0.01969519,
-0.016523497,
0.014899284,
0.024849191,
-0.014835338,
-0.01313439,
-0.009534262,
-0.0122391535,
0.01480976,
-0.032381963,
0.0037535962,
-0.01186827,
0.0023611847,
-0.0041308743,
-0.027291907,
-0.009937119,
-0.0036832565,
-0.0070467857,
0.03629542,
-0.012987316,
-0.0071427035,
-0.05698816,
-0.0083193,
0.019119682,
-0.016037513,
0.010717253,
0.01690717,
-0.011580516,
-0.0005139613,
0.012469358,
-0.15848233,
0.028980065,
0.02515613,
-0.024785247,
0.02808483,
-0.01814771,
0.0014931256,
-0.012904187,
0.030565912,
0.020756684,
0.035144404,
-0.01592241,
-0.033686448,
0.014285407,
0.017700093,
-0.0032084617,
0.011446231,
0.031947132,
0.02780347,
0.006995629,
0.00356176,
-0.025450278,
0.021191513,
-0.021268247,
-0.015270167,
0.02277736,
0.003644889,
0.021703076,
-0.011970583,
0.010736437,
-0.01674091,
0.018390704,
0.035042092,
-0.008370455,
0.012028134,
-0.002610572,
0.00007433655,
-0.0122391535,
-0.0022828516,
0.011542149,
0.060927197,
0.032867946,
0.0072705946,
0.012002556,
-0.020590426,
0.0203858,
0.011407863,
0.008913992,
0.015155065,
0.012578065,
0.046066284,
0.015385268,
0.004562506,
0.0044537988,
-0.0054801228,
-0.0046072677,
-0.0018672063,
-0.000006594372,
0.005847809,
-0.0067270584,
-0.015999144,
-0.044173498,
0.025309598,
0.010582968,
-0.0025210483,
-0.025041027,
-0.010435893,
-0.0028503672,
-0.01983587,
0.009304059,
-0.024069058,
0.00537781,
0.012347861,
0.009406372,
0.034249168,
0.0054449528,
0.0032931892,
0.0043450915,
-0.0131216,
-0.00018803951,
0.0055280817,
-0.012961737,
-0.013096022,
-0.026371092,
-0.0114526255,
0.0034274748,
0.029721832,
0.014566767,
-0.012584459,
-0.0024155383,
0.01983587,
-0.04036235,
0.016293293,
-0.022329742,
-0.013051261,
0.024682933,
0.02348076,
0.005918149,
0.035937328,
-0.00048638487,
0.01068528,
-0.011350312,
0.0040477454,
0.01117766,
0.014835338,
-0.001868805,
-0.022508789,
-0.03087285,
0.021728655,
-0.000013950593,
-0.007136309,
0.005240327,
0.0003263215,
0.009252903,
0.003513801,
0.032279648,
0.0031301284,
-0.01179793,
0.028289454,
-0.013530851,
0.054430343,
0.006944473,
0.004719172,
0.020168386,
-0.0069188946,
-0.02348076,
-0.124309905,
-0.043917716,
0.02263668,
-0.010934668,
0.0042267926,
0.031230945,
-0.0041212826,
-0.013594797,
-0.019477775,
0.023685385,
-0.019810291,
-0.003096557,
-0.012565276,
0.0024810825,
0.02977299,
-0.0067270584,
0.0063849506,
-0.021447295,
-0.017073428,
0.027675578,
-0.007014813,
-0.024465518,
-0.006861344,
-0.017648937,
0.0039262488,
0.009956302,
-0.021408927,
0.00036868532,
-0.0012781092,
0.018480226,
0.009105829,
0.016856013,
0.003118938,
-0.00048718418,
-0.0073217507,
0.0099754855,
-0.017265264,
-0.027675578,
0.023161031,
-0.021549607,
-0.0045177443,
0.023135453,
0.014592346,
0.012354256,
-0.01844186,
-0.0039806026,
-0.023288922,
-0.017700093,
0.020961309,
-0.0181605,
-0.009233719,
-0.030744959,
-0.024977082,
-0.015756153,
0.005930938,
-0.012699561,
0.0068933167,
0.029363738,
0.017290842,
-0.0018256418,
0.017226897,
0.012104869,
-0.024069058,
0.026345514,
0.019324306,
-0.018224446,
0.010160928,
-0.008562292,
-0.005396994,
-0.019887026,
0.00097037177,
-0.003299584,
-0.023864431,
-0.01341575,
-0.011548543,
0.0053682183,
0.00026037777,
-0.030770537,
0.024529465,
-0.03798358,
-0.0055856328,
-0.0135052735,
0.027547687,
-0.011126503,
0.040746022,
-0.0037759773,
0.004895022,
0.0018943831,
0.008479163,
0.0070467857,
-0.0021821375,
0.028980065,
0.016190981,
-0.025322387,
0.0076031107,
0.010013853,
-0.0064361067,
-0.01096664,
0.026371092,
0.010103377,
-0.011682829,
0.004038153,
-0.040285617,
0.012213576,
0.00019583285,
0.0131216,
0.0018624105,
-0.017252475,
-0.0026201636,
-0.015960777,
0.014733026,
0.006957262,
-0.02041138,
0.035604812,
0.00046360432,
-0.004508152,
-0.016523497,
-0.020475324,
0.00016725724,
0.0014507618,
0.015884044,
0.021268247,
0.0020590427,
0.009272086,
0.016894381,
0.023659807,
0.0014028028,
0.016280504,
-0.002965469,
0.026473405,
-0.02765,
-0.009284875,
0.024478307,
-0.011267183,
-0.01466908,
0.0009216134,
-0.021472873,
-0.023352869,
-0.007814131,
0.034172434,
0.023352869,
0.03813705,
0.018134922,
-0.025322387,
-0.0003195273,
-0.014067993,
0.00047279647,
-0.025168918,
-0.025782794,
0.028059252,
-0.006899711,
-0.0063114134,
0.00038387236,
0.0125205135,
-0.005697537,
-0.03813705,
-0.00733454,
-0.00039386383,
0.013556429,
-0.0075327707,
-0.048163693,
-0.016958326,
0.0059629106,
0.016676966,
-0.005000532,
0.0015930403,
0.029798567,
-0.032356385,
-0.0391346,
-0.006193114,
0.006925289,
-0.020475324,
-0.010148139,
0.008639026,
0.0015706595,
0.01167004,
0.0029191086,
0.0028759453,
-0.0014707447,
0.022738993,
0.014272618,
0.041308742,
-0.00037248209,
0.0137866335,
-0.042869013,
0.01717574,
0.04038793,
-0.0033571348,
-0.016101457,
0.014835338,
0.019183626,
0.007948416,
-0.001644996,
0.02670361,
-0.00565917,
0.021754233,
0.016510708,
0.021076411,
-0.0102568455,
0.0076222946,
0.01082596,
0.017521046,
0.0035457737,
-0.016421184,
-0.0188639,
-0.010007459,
-0.01229031,
-0.0035201956,
-0.009355215,
-0.033993386,
-0.025808373,
0.025603747,
0.012322283,
0.016804857,
0.0050197155,
-0.0035585628,
-0.022854093,
0.012335072,
-0.009176169,
0.008901203,
-0.004114888,
0.011401469,
0.014860916,
0.011829903,
-0.007750185,
0.001401204,
0.024567831,
0.021703076,
-0.0066759023,
-0.019209204,
0.015525948,
-0.0024139397,
0.025335176,
-0.009240113,
-0.037011612,
-0.016152613,
-0.02403069,
-0.046756893,
0.0127315335,
-0.010563783,
-0.0032084617,
0.0601087,
0.005521687,
-0.007820525,
-0.000108407476,
-0.023826065,
0.021217091,
0.007417669,
0.0055152928,
-0.03169135,
0.00747522,
0.0159352,
-0.02069274,
-0.0035106037,
-0.044915266,
-0.022137905,
0.035528075,
0.014285407,
-0.0038655007,
0.00019373465,
-0.013198336,
-0.0030773734,
0.0024443138,
0.0011230415,
-0.0016250131,
-0.03015666,
-0.00810828,
0.027880205,
0.017099006,
0.0006534423,
-0.0524864,
-0.022687836,
-0.004636043,
-0.013876157,
-0.003971011,
0.04079718,
-0.0077310014,
-0.012187998,
-0.035707124,
0.008639026,
0.012514119,
-0.009246508,
0.0036289028,
-0.03675583,
-0.025092185,
-0.039083444,
-0.0014691461,
-0.0133645935,
-0.028135985,
-0.020935731
] |
A significant fraction of the human genome is transcribed as non-coding RNAs (ncRNAs). This non-coding transcriptome has challenged the notion of the central dogma and its involvement in transcriptional and post-transcriptional regulation of gene expression is well established. Interestingly, several ncRNAs are dysregulated in cancer and current non-coding transcriptome research aims to use our increasing knowledge of these ncRNAs for the development of cancer biomarkers and anti-cancer drugs. In endocrine-related cancers, for which survival rates can be relatively low, there is a need for such advancements. In this review, we aimed to | [
-0.03375528,
-0.016956324,
0.0038161564,
-0.016130146,
0.019513542,
-0.009678087,
-0.019080782,
0.017900528,
-0.025506614,
0.0024096863,
0.0072979075,
-0.0006593853,
-0.016995667,
-0.003319466,
0.0105895065,
0.0080060605,
0.026844235,
-0.0036161689,
0.0064586154,
-0.012346774,
-0.024064079,
0.013651611,
-0.015067917,
-0.0023293635,
-0.02968996,
0.022490406,
0.014923664,
-0.03685017,
-0.0042751445,
-0.031316087,
0.009278112,
0.0067995777,
-0.011573052,
-0.012471356,
-0.006747122,
-0.004799702,
-0.0075208447,
-0.012202521,
0.023893598,
-0.013428674,
0.03152591,
0.015841639,
-0.013690953,
-0.0063307546,
0.011841888,
0.003170295,
0.017848073,
-0.0051144366,
-0.000041467712,
0.026057398,
0.0016474387,
0.004593157,
-0.019880733,
-0.019618453,
-0.016261285,
0.0131598385,
0.00018257063,
0.032627482,
0.012084495,
-0.005078373,
0.0043505495,
-0.007029072,
-0.014084372,
0.008333908,
-0.00042251474,
0.02150686,
0.019579113,
-0.0030801366,
0.009842012,
0.004022701,
0.0090223905,
0.009763328,
-0.022542862,
0.024155878,
0.02190028,
-0.035066675,
0.00069667806,
-0.0018228376,
-0.0017064514,
0.012438572,
0.008051959,
0.007166768,
0.0017523502,
-0.005442285,
0.009940366,
0.014228624,
-0.0048259296,
0.01594655,
0.014805638,
-0.016798956,
0.02369689,
0.015330195,
0.016366197,
0.023919826,
-0.009396138,
-0.021021646,
0.0023883763,
0.03598465,
-0.007415933,
-0.042121977,
-0.0150023475,
0.03441098,
-0.010609177,
-0.0060586403,
-0.022778913,
-0.0057373485,
0.026450817,
-0.0031194785,
0.028457249,
-0.007992947,
-0.025309904,
0.02066757,
-0.020090556,
-0.020811822,
0.044456255,
-0.002622788,
0.0318931,
0.0035735485,
-0.019552885,
-0.029637504,
0.024746004,
0.011455026,
0.020457746,
-0.031080037,
0.013927004,
0.023421496,
0.004150562,
0.013704067,
-0.003603055,
-0.004212853,
0.002283465,
-0.0151466,
0.013507358,
0.015238398,
-0.03637807,
-0.010130518,
-0.008314238,
-0.013704067,
-0.0060324124,
-0.03732227,
-0.00049996894,
0.041230228,
-0.031106265,
0.007592971,
-0.0044587394,
0.014936778,
0.025493499,
0.0034358522,
0.022241242,
-0.0021638002,
-0.00014199938,
-0.011671406,
0.018097237,
-0.02226747,
-0.016248172,
0.019434858,
0.008825681,
0.012713965,
0.00022273207,
-0.008819125,
0.009979708,
-0.0017867743,
0.02426079,
0.011028823,
0.016969439,
0.017598907,
-0.0151466,
0.0013335238,
-0.008773225,
-0.021742912,
0.0003503881,
0.022516634,
-0.033833966,
0.012950015,
-0.015697386,
0.021729799,
-0.023277244,
0.02300185,
-0.037715692,
-0.018713592,
0.008012617,
0.0063307546,
0.026136082,
0.012923787,
-0.019684024,
-0.00085486495,
0.017834958,
0.0052062343,
-0.009691201,
-0.016497336,
-0.018870959,
0.0036555107,
0.028667072,
-0.00012314809,
-0.6294691,
-0.024811573,
0.02479846,
-0.026411476,
0.01860868,
0.0013031978,
-0.0042489166,
-0.025742663,
-0.016851412,
0.041177772,
-0.019421745,
0.009330568,
0.040233567,
-0.009205986,
-0.03467326,
-0.04710527,
-0.007009401,
-0.008910922,
0.03079153,
0.0056127664,
-0.022988737,
0.017415313,
0.016589133,
0.015474449,
-0.0056947283,
0.009074846,
0.011127178,
0.0064455015,
-0.0019867618,
0.010766544,
-0.027749097,
0.011855002,
-0.02183471,
-0.00042251474,
0.04789211,
0.0075142877,
-0.0043341573,
0.023880484,
0.0151466,
0.015513791,
-0.0005794722,
-0.007920819,
0.009317454,
0.016051462,
-0.022516634,
0.0076585407,
-0.0036882956,
-0.009848569,
0.021231469,
-0.022464179,
-0.012950015,
0.011579609,
-0.0048619932,
-0.014084372,
-0.009337125,
0.0048652715,
0.03650921,
-0.026713096,
0.028404795,
-0.0044915243,
-0.011343558,
0.014858094,
-0.015631815,
-0.017126806,
0.0008835517,
-0.0035669915,
-0.008209326,
0.010622291,
-0.00612421,
0.012891003,
0.015461335,
0.028011376,
0.010956697,
-0.0091469735,
0.0043767774,
0.04141382,
0.012477914,
-0.0063766534,
0.009264998,
0.018516883,
0.0065012355,
0.006740565,
-0.03758455,
0.008038845,
0.015330195,
-0.012340218,
-0.0092977835,
0.022778913,
0.019710252,
0.010969811,
-0.0014843341,
0.012851661,
-0.0071011987,
-0.04033848,
-0.014936778,
0.011861559,
0.009579733,
0.022739572,
0.021231469,
-0.024352586,
-0.0026867185,
-0.0022818255,
-0.005671779,
-0.00936991,
-0.0051537785,
-0.01131733,
-0.016103918,
0.011435356,
0.019513542,
-0.036797713,
-0.005806197,
-0.017048122,
-0.024444385,
-0.000033886216,
-0.012523812,
-0.018110352,
0.025650866,
-0.0021260974,
-0.0043013724,
-0.024693549,
-0.009940366,
0.0003932133,
-0.010215759,
-0.0094485935,
0.012851661,
-0.005504576,
-0.0044161193,
-0.01927749,
-0.0054652346,
-0.016667817,
-0.0054390067,
-0.02919163,
0.020549543,
-0.018149693,
-0.00007166563,
-0.002845725,
0.020457746,
0.021559317,
-0.010819,
-0.025703322,
-0.0052160695,
0.0038259919,
0.010137076,
0.007199553,
-0.004973462,
-0.009474821,
-0.027617957,
0.004252195,
0.020720026,
0.016431767,
-0.017166147,
-0.008779783,
-0.016995667,
0.008458491,
0.0057307915,
-0.010071506,
-0.017100578,
-0.029611276,
-0.012818877,
-0.014294194,
-0.01348113,
0.02356575,
-0.017153034,
0.010996039,
-0.0012974604,
-0.0021113444,
-0.018071009,
0.03685017,
-0.008969935,
-0.021113442,
0.006629097,
-0.016248172,
-0.014176169,
0.016982552,
0.0016720273,
0.013304092,
-0.026647525,
0.0037473084,
-0.0021113444,
-0.026044285,
-0.028876895,
-0.022818256,
-0.027486818,
-0.011697634,
0.009101074,
0.043354686,
0.038895946,
-0.012654952,
0.004514474,
0.030135835,
-0.026581956,
0.0025096803,
-0.028247427,
0.040469617,
0.013743409,
-0.035197813,
0.011586166,
0.0015933437,
0.0048652715,
0.010143632,
0.019133238,
-0.014805638,
-0.007802794,
0.0039899163,
-0.004970183,
-0.02133638,
0.010766544,
-0.0011023906,
0.0039866376,
-0.01428108,
-0.004173511,
0.017061235,
0.010445253,
-0.00021494567,
-0.012818877,
0.008281453,
-0.023919826,
-0.0014523688,
-0.0009433841,
0.0014318783,
-0.010176417,
-0.0064848433,
0.0029555543,
0.00009451257,
-0.00913386,
0.01923815,
0.008851909,
0.007061857,
-0.000039136914,
-0.008019174,
-0.0014466315,
0.02486403,
-0.01131733,
-0.018621795,
0.01527774,
0.003326023,
0.002116262,
-0.02393294,
0.02609674,
0.00073929835,
-0.015684271,
-0.004625942,
0.0038489413,
-0.016864527,
0.002778516,
0.0034096243,
0.033309408,
0.012412344,
-0.014608929,
-0.006160273,
-0.009730543,
0.016523564,
-0.014635157,
0.022044532,
0.013625383,
-0.03066039,
-0.008910922,
0.01144847,
0.05701941,
0.022542862,
0.007429047,
-0.0022490406,
0.008760111,
-0.022542862,
-0.018385744,
-0.01527774,
0.026136082,
-0.0064028814,
-0.013120497,
0.016772728,
-0.03105381,
-0.02795892,
0.021677343,
-0.020313492,
0.0112911025,
0.012536926,
-0.009756771,
0.012792649,
0.027906464,
0.007822465,
-0.0063799317,
-0.0018605402,
0.044718534,
0.037768148,
-0.011658292,
-0.025585297,
-0.03881726,
0.011651736,
-0.016471108,
0.008314238,
0.010976368,
0.0064192736,
0.005098044,
0.007127426,
0.0021703572,
0.003901397,
0.0184382,
-0.016221944,
0.00822244,
-0.013690953,
0.020156126,
-0.013953232,
0.006186501,
-0.00714054,
0.015854754,
0.015880981,
-0.014923664,
0.002042496,
-0.01737597,
-0.016825184,
-0.017218603,
0.007822465,
0.024195218,
-0.034935534,
0.003291599,
0.010392797,
0.018962758,
0.00698973,
0.0051865634,
0.028011376,
-0.01927749,
-0.02430013,
-0.009553505,
0.009730543,
0.045925017,
0.011907457,
-0.029165402,
0.022621546,
0.008740441,
-0.0022359267,
-0.032129154,
-0.008799453,
0.015474449,
-0.03325695,
-0.013100826,
0.0026047563,
0.007383148,
0.008668315,
0.0097371,
0.016182601,
-0.0021260974,
-0.038764805,
-0.024759118,
-0.0052488544,
0.012891003,
0.02226747,
0.015828526,
0.043984156,
0.029139174,
-0.017192375,
0.004022701,
0.0078683635,
0.0092191,
-0.017612021,
-0.00060774916,
0.026686868,
-0.01146814,
0.017021894,
-0.0027981868,
0.011461583,
0.03936805,
0.016641589,
0.016720273,
0.004589879,
0.027119627,
0.014897436,
0.03165705,
-0.002953915,
-0.0026621297,
-0.018831618,
-0.0031620988,
0.016156374,
0.0019670909,
-0.013218852,
0.0034424092,
-0.017362857,
-0.007494617,
-0.011573052,
0.02426079,
-0.02559841,
0.00573407,
-0.0021310153,
0.004081714,
-0.005383272,
-0.0054783486,
-0.007035629,
0.004957069,
0.0051603355,
-0.007914263,
-0.009343682,
-0.009481379,
-0.01008462,
-0.00011310773,
0.0011269792,
0.009487935,
-0.03315204,
-0.01800544,
0.01927749,
0.018792275,
0.0032735672,
0.0053636013,
-0.035512548,
0.0065340204,
0.011376343,
-0.009940366,
-0.022975622,
0.01986762,
-0.025572183,
0.0071011987,
-0.015461335,
-0.0056455513,
-0.011861559,
-0.014766296,
0.008274896,
0.0015031854,
-0.010596063,
0.017651362,
-0.00021822416,
-0.0007556908,
0.028378567,
0.013094269,
0.02113967,
0.027749097,
-0.01016986,
-0.005022639,
-0.008051959,
-0.023447724,
-0.03338809,
0.0010974729,
-0.022293698,
0.0036620677,
0.028299883,
-0.00067782676,
-0.024942713,
0.03721736,
-0.00551769,
0.000028994102,
0.020785594,
0.0073110214,
0.0094354795,
-0.017887414,
0.0265295,
-0.005412779,
-0.007579857,
-0.017087463,
0.007802794,
0.015474449,
-0.0000058365995,
-0.003271928,
0.015920322,
0.0026277057,
-0.0075077307,
-0.025506614,
-0.00013052468,
-0.0014335176,
0.03957787,
0.014018802,
-0.03918445,
0.004022701,
-0.020090556,
0.011068165,
0.0046947906,
-0.002237566,
0.0020179076,
-0.02213633,
0.009632189,
0.0036292828,
-0.01737597,
0.005052145,
-0.038266476,
-0.006983173,
0.027145855,
0.007947047,
0.004799702,
-0.0016080969,
0.0040522073,
-0.0162744,
-0.03427984,
-0.0024014902,
-0.014228624,
0.007383148,
-0.010773102,
0.05048867,
0.013304092,
0.031184949,
0.0021654393,
-0.014949892,
0.032679938,
0.01793987,
-0.0005405402,
0.006645489,
0.021480633,
-0.01146814,
0.0009442037,
0.011625508,
-0.003488308,
0.0057504624,
-0.018490655,
0.0077241105,
0.008327352,
-0.02319856,
-0.021860939,
0.0024293573,
-0.02047086,
-0.06441567,
0.012202521,
-0.014320422,
0.014163055,
-0.0168383,
0.0028506427,
0.03365037,
0.0010802608,
0.0302932,
-0.021624887,
0.010766544,
0.007802794,
0.0030440732,
-0.0011417324,
0.018503768,
-0.023146104,
-0.013402446,
-0.023342812,
-0.00020931078,
0.017848073,
-0.009422366,
0.03650921,
0.01477941,
-0.017415313,
0.0064815646,
0.0018851289,
-0.046921678,
-0.016182601,
-0.008589631,
-0.02226747,
0.0020933126,
-0.0063241976,
-0.015736727,
-0.046239752,
0.0013228686,
0.009468265,
-0.0062914127,
0.022752685,
-0.007061857,
-0.03498799,
0.014399106,
-0.005543918,
0.023591978,
-0.012851661,
0.017756274,
0.014569587,
-0.02016924,
-0.03918445,
-0.017100578,
-0.00009953276,
-0.0200381,
0.03488308,
0.008209326,
-0.007888035,
-0.008891251,
0.01813658,
0.007907705,
-0.0031047252,
-0.02832611,
0.0077962372,
0.0018162807,
-0.011651736,
-0.0021506862,
-0.0078814775,
-0.0064717294,
0.009055176,
-0.019461086,
0.015841639,
-0.020011872,
0.00047210185,
-0.01248447,
0.005429171,
-0.0061274883,
0.015618702,
-0.001757268,
-0.0064323875,
-0.019854505,
0.00077905,
-0.0069372742,
0.0004169823,
-0.0025785284,
0.033073355,
0.0055406396,
-0.0072782366,
0.042594075,
-0.016300628,
0.005678336,
0.006779907,
0.0008860106,
0.042489164,
-0.020418404,
-0.0055603106,
0.036430527,
0.0075208447,
0.009251884,
0.016169488,
-0.004557094,
-0.009881354,
-0.04254162,
-0.0011417324,
0.020575771,
0.015579361,
-0.0077831233,
-0.02207076,
-0.001865458,
-0.006714337,
-0.038266476,
-0.02732945,
0.008261782,
-0.029034263,
-0.024234561,
0.0063799317,
0.040390935,
0.02843102,
0.0061012604,
-0.010471481,
-0.018241491,
0.028535932,
-0.0044030054,
0.01737597,
-0.0024375536,
-0.0135860415,
-0.014163055,
0.0194742,
-0.009101074,
-0.03105381,
0.022083875,
-0.0341487,
-0.024313245,
0.018110352,
-0.009402695,
0.030371884,
0.023106761,
-0.025611525,
0.016785843,
0.019080782,
0.003557156,
0.007586414,
-0.033493,
0.013389332,
-0.01687764,
-0.0026719652,
0.004183347,
0.028168743,
-0.004271866,
-0.01906767,
-0.007960161,
0.013087712,
0.0019556163,
-0.0030063707,
-0.0132844215,
0.005137386,
-0.0076847686,
0.020615114,
0.012858218,
-0.013166396,
-0.012792649,
0.037715692,
0.013068041,
0.011612394,
-0.0049242843,
-0.0061963364,
0.01421551,
0.010805886,
-0.008314238,
-0.0003270289,
-0.012602496,
-0.014818752,
-0.051170595,
0.00850439,
-0.0021621608,
0.029506365,
0.00072003726,
-0.0115927225,
-0.02289694,
-0.002893263,
-0.04453494,
-0.03005715,
0.016418653,
0.040286023,
0.01990696,
0.031342316,
0.0035866625,
0.0039243465,
-0.012169736,
0.011828774,
0.013717181,
-0.008661757,
0.008714213,
0.0105763925,
-0.008458491,
0.009986266,
-0.034227382,
0.0037637008,
0.05269181,
-0.009166644,
-0.030214518,
0.0107272025,
-0.017048122,
0.031237405,
-0.029480137,
-0.007068414,
-0.0054652346,
0.01754645,
0.039525416,
-0.026136082,
-0.013664725,
0.017257946,
-0.003339137,
-0.016484223,
0.014674499,
-0.018857846,
0.014582701,
-0.0008671593,
-0.0064684507,
-0.03511913,
0.020064328,
-0.0064094383,
-0.0056324373,
0.034620803,
-0.010582949,
0.024090307,
0.012202521,
-0.016156374,
-0.026057398,
-0.034542117,
-0.03152591,
-0.0034194598,
0.014556473,
-0.0044161193,
-0.009599404,
0.0013867992,
-0.004576765,
-0.024352586,
-0.011205861,
-0.005002968,
-0.0128844455,
-0.0032538963,
-0.010412469,
-0.012071381,
-0.018543111,
0.0061537162,
0.00080404844,
-0.01800544,
-0.012779535,
-0.004160397,
-0.017389085,
-0.004514474,
0.022910053,
-0.00112534,
0.0069372742,
-0.019316833,
-0.016785843,
-0.007120869,
-0.02683112,
0.0058717667,
0.1894702,
-0.023224788,
-0.020051215,
0.002090034,
0.0015597392,
-0.0157105,
0.022241242,
-0.01967091,
-0.015054803,
0.009160087,
0.013094269,
0.0033899534,
-0.027749097,
0.004144005,
0.012707408,
-0.006638932,
-0.039604098,
-0.021716684,
-0.0018146414,
0.009763328,
-0.0052160695,
-0.0033293015,
-0.022254355,
-0.014608929,
0.026214765,
0.00357027,
-0.02649016,
0.008996163,
0.009337125,
-0.0005975039,
-0.054449078,
-0.0023670662,
0.01986762,
0.0060684755,
0.009514163,
0.021992078,
0.014517131,
0.011094393,
-0.005819311,
-0.030476796,
0.0023490344,
0.0076650977,
0.011959913,
-0.0047636386,
0.04010243,
0.0076913256,
-0.011704192,
-0.0008950264,
-0.018857846,
-0.010123962,
-0.04542669,
0.020864278,
-0.0001663831,
0.029086718,
0.0077700093,
0.011055051,
0.00009763738,
0.016221944,
-0.003068662,
0.03572237,
-0.006517628,
-0.0012892642,
-0.007448718,
0.014858094,
-0.01967091,
0.030319428,
-0.010582949,
0.006563527,
0.033204496,
-0.010320671,
-0.0040456504,
-0.015579361,
-0.022424838,
0.0003624775,
-0.004455461,
-0.010563279,
0.034909308,
0.011835331,
0.0044226763,
0.02955882,
0.014097486,
-0.018228376,
-0.036561664,
-0.026503272,
0.022464179,
-0.052141026,
0.014058144,
-0.0038391058,
-0.012818877,
-0.020090556,
0.009796113,
-0.009914138,
-0.024195218,
0.004570208,
-0.00044095624,
-0.00063766533,
-0.014674499,
-0.009330568,
0.001737597,
-0.025768891,
-0.038633667,
0.084873416,
-0.011192747,
0.026188537,
-0.0024555852,
0.009894468,
0.00014599503,
-0.0060651973,
0.0011237008,
-0.009251884,
-0.00017539895,
-0.00837325,
0.031027582,
-0.01927749,
0.0027883514,
0.023539523,
0.024746004,
-0.027513046,
0.024208333,
-0.015828526,
-0.0138614345,
-0.028614616,
-0.012405787,
0.017743161,
-0.019447973,
0.01744154,
0.008943707,
-0.005717678,
-0.009324011,
-0.025532842,
0.005996349,
-0.013494244,
0.0012646755,
-0.010897684,
-0.0032752065,
-0.0384763,
0.036482982,
-0.0008044582,
-0.0023228065,
0.01860868,
-0.006084868,
-0.009461707,
-0.00057742314,
0.0005934058,
0.0060651973,
-0.014123714,
0.019552885,
-0.012641838,
0.009855126,
-0.003150624,
-0.01620883,
-0.011264875,
0.0036686247,
0.02016924,
0.016825184,
-0.008150314,
-0.009474821,
-0.03921068,
-0.0038784477,
0.0016744862,
-0.036797713,
0.0094354795,
0.03427984,
-0.001540888,
0.00677335,
-0.0026326235,
-0.1631374,
0.0053701582,
0.004035815,
-0.024313245,
0.025795119,
0.019421745,
0.0022162558,
0.010143632,
0.023749346,
0.0056619435,
0.0042882585,
-0.01348113,
-0.03661412,
-0.03601088,
0.0150023475,
0.013251636,
-0.003258814,
0.03178819,
0.022923166,
0.0045111952,
0.024221446,
-0.021152785,
0.016038349,
-0.031604595,
-0.012477914,
0.004534145,
-0.009042062,
-0.025965601,
-0.011061608,
-0.002053971,
-0.021546204,
0.006697945,
0.010392797,
-0.0046620057,
0.012392673,
0.025768891,
0.0030194847,
-0.0135991555,
-0.016195716,
0.0022555976,
0.026149197,
0.020759366,
0.008753555,
-0.0036719032,
-0.012812319,
0.024024738,
0.008930593,
-0.015854754,
0.0043144864,
0.013520472,
0.020654455,
0.000015854548,
0.0016080969,
0.0034456877,
0.01326475,
0.006760236,
0.00034116735,
0.03375528,
0.012825433,
-0.0020572494,
-0.015526905,
-0.022647774,
-0.0017326793,
0.0065471344,
0.011133735,
-0.017533338,
-0.0077896803,
0.000525787,
-0.009245328,
0.0015072834,
-0.033283178,
-0.011756647,
0.00012950016,
0.00021719963,
0.015435107,
0.0030407947,
-0.022280583,
0.024037851,
-0.0115927225,
0.0044095623,
0.00378665,
-0.008333908,
-0.038056653,
-0.0114419125,
0.027172083,
-0.024352586,
0.016680932,
0.011127178,
-0.0014351568,
-0.00095649797,
0.022778913,
-0.007048743,
0.02133638,
-0.0117173055,
0.024693549,
0.010897684,
0.015789183,
-0.015920322,
0.001737597,
-0.028404795,
0.026778664,
0.000007504657,
-0.014582701,
0.010123962,
0.04303995,
0.01737597,
-0.023028078,
-0.0068389196,
0.0464758,
-0.008458491,
-0.009697759,
0.015920322,
0.0168383,
0.024746004,
0.008176542,
0.04096795,
-0.016733387,
-0.002711307,
-0.007947047,
-0.016012121,
0.07438227,
0.004180068,
0.006760236,
0.019198809,
0.0013753244,
-0.024273902,
-0.13795865,
-0.024405042,
0.020365948,
-0.00030285004,
-0.023473952,
0.030948898,
-0.02176914,
0.042462938,
-0.025808234,
0.028850667,
-0.028404795,
0.01166485,
-0.016982552,
0.007579857,
0.00007151195,
-0.01577607,
-0.0034129028,
-0.012943459,
-0.0063635395,
0.022083875,
0.011330444,
0.0049373982,
0.014438448,
-0.02536236,
0.00993381,
0.013277864,
-0.0233297,
-0.012104167,
0.014202397,
0.00123353,
-0.0056619435,
-0.008884694,
0.011697634,
-0.009599404,
-0.013559814,
-0.003488308,
-0.0052357404,
-0.017100578,
0.026568843,
-0.0070815277,
-0.005816032,
0.017743161,
0.0009974791,
0.0030588266,
-0.008340466,
-0.021165898,
-0.018385744,
-0.00056758773,
-0.004212853,
-0.02696226,
-0.020916734,
-0.02906049,
-0.021572432,
-0.030398112,
0.0368764,
-0.013572928,
0.016248172,
0.02843102,
-0.0021638002,
-0.024339473,
-0.0053570443,
0.019933188,
-0.011173077,
0.013343434,
0.0014269606,
-0.015828526,
-0.021782255,
-0.012976243,
0.02079871,
-0.030739075,
0.00417679,
0.0056258803,
-0.012379559,
-0.0072257807,
-0.026673753,
0.022870712,
-0.021795368,
-0.019028326,
0.016628476,
-0.018648023,
-0.010963254,
-0.018792275,
0.030240746,
-0.025572183,
0.016825184,
0.0008425706,
0.0049242843,
-0.016169488,
0.000571276,
-0.0027670413,
-0.0066422108,
0.030817758,
-0.02479846,
-0.007002844,
0.00493412,
0.004514474,
-0.014608929,
-0.01767759,
0.0064422227,
0.019985644,
-0.0021670787,
-0.007383148,
-0.040626984,
-0.0100124935,
0.007022515,
-0.0194742,
0.011953356,
-0.036561664,
-0.0042161318,
0.013441788,
-0.006537299,
0.009940366,
-0.017035007,
0.006740565,
-0.017362857,
0.003367004,
-0.025073852,
-0.002908016,
0.031945556,
-0.0092977835,
0.024641093,
0.041649874,
0.005970121,
-0.00026391805,
0.013074598,
0.008563403,
-0.0032473393,
-0.009186314,
-0.008622415,
0.014569587,
-0.004606271,
-0.030765302,
0.012654952,
-0.0072585656,
-0.010989482,
-0.0049046134,
-0.0038030425,
-0.0061897794,
0.003691574,
0.03858121,
0.021008532,
0.05429171,
-0.009671531,
-0.048416667,
0.0081568705,
0.010497709,
0.0038423843,
0.017402198,
-0.045295548,
0.009717429,
0.018241491,
-0.0055471966,
0.028955579,
0.019526657,
0.0042489166,
-0.010838672,
-0.0016630115,
-0.003393232,
0.007002844,
-0.024903372,
0.004957069,
-0.015408879,
0.019434858,
0.022162559,
-0.014176169,
0.0053308164,
-0.0038915616,
0.0032440608,
-0.033571687,
-0.017848073,
0.012300876,
-0.015133486,
-0.011074722,
0.013343434,
0.017716933,
-0.01936929,
0.0034555232,
-0.007861807,
-0.042856354,
0.0012195964,
0.003340776,
0.035565004,
0.007494617,
0.012451686,
0.0039735236,
0.029637504,
0.0138745485,
0.015959665,
-0.004550537,
-0.0013810617,
0.0009876436,
0.01196647,
-0.00043644832,
0.015736727,
0.013730295,
0.025126308,
0.0028850667,
0.012412344,
-0.024234561,
0.030712847,
-0.0029489973,
0.021113442,
0.012851661,
0.0026145917,
0.012169736,
-0.020392176,
-0.024155878,
0.03215538,
-0.015500677,
-0.013153282,
-0.001858901,
0.0075601866,
0.0008253586,
-0.005927501,
-0.005760298,
-0.0118812295,
-0.027014716,
0.0018785719,
-0.0042358027,
-0.007802794,
-0.034096245,
0.026555728,
0.014294194,
0.018425085,
0.006429109,
0.010333785,
0.005901273,
0.028457249,
0.018818503,
-0.018097237,
0.0061471593,
-0.015985893,
0.006661881,
-0.013625383,
-0.043118633,
-0.0030916114,
-0.009487935,
-0.005347209,
-0.0013056566,
0.0048783855,
-0.01927749,
0.057543967,
0.0249296,
-0.010091176,
0.023277244,
-0.021519976,
0.037269816,
0.00067577773,
0.008386364,
-0.020641342,
-0.010714089,
0.011769761,
-0.033440545,
0.02053643,
-0.056127664,
0.0043079294,
0.038082883,
0.000532344,
0.042095747,
-0.0135860415,
-0.013953232,
0.002090034,
-0.021874052,
0.0057439054,
0.0019900403,
-0.024142763,
0.0005360323,
0.037741918,
-0.0047013476,
-0.00029219498,
-0.018018553,
0.010215759,
-0.013940118,
-0.018923415,
0.023028078,
0.01817592,
0.0033506115,
-0.004098106,
-0.009042062,
0.037427183,
0.021874052,
0.040364705,
-0.008261782,
-0.0100124935,
-0.012825433,
-0.00906829,
-0.0033997889,
-0.021060988,
-0.011133735,
-0.014871208
] |
Nonspecific protein-DNA interactions are inherently dynamic and involve both diffusion of the protein along the DNA and hopping of the protein from one DNA molecule or segment to another. Understanding how gene regulatory proteins interact nonspecifically with DNA in terms of both structure and dynamics is challenging because the experimental observables are an ensemble average of many rapidly exchanging states. By using a variety of NMR spectroscopic techniques, including relaxation analysis, paramagnetic relaxation enhancement, and residual dipolar couplings, we have characterized structural and kinetic aspects of the interaction of the HoxD9 homeodomain with a nonspecific, 24-bp DNA duplex in a | [
-0.036378868,
0.0023053042,
-0.00074901583,
-0.018402487,
-0.013515575,
0.025273459,
-0.005559362,
0.0063882726,
-0.04628585,
-0.014407735,
0.0063516544,
-0.0054262034,
0.014634104,
0.008295766,
-0.0029194972,
-0.013728628,
0.030147055,
-0.015965689,
0.0057491125,
0.006195193,
-0.016924428,
0.0011043822,
-0.020399863,
-0.009028138,
-0.019161489,
0.028176311,
0.008408951,
-0.029055156,
-0.005705836,
-0.015366476,
0.008888321,
0.0064248913,
-0.021425182,
-0.012816493,
0.019627543,
-0.008262477,
-0.0039514746,
0.014913737,
0.020479757,
-0.02210429,
0.016112162,
-0.011891042,
-0.02277008,
-0.023009766,
-0.01026651,
-0.0023752125,
0.013315837,
-0.005799047,
-0.00078230543,
0.004427516,
0.0061619035,
0.011125382,
-0.0011501554,
-0.006997472,
0.012956309,
-0.0026631674,
0.030253582,
0.011598094,
0.007090683,
-0.02203771,
-0.010612722,
0.019840596,
-0.009733877,
0.00399808,
-0.023941875,
0.011990911,
0.013156047,
-0.00700413,
0.013555522,
0.007423579,
0.028362732,
0.013981629,
-0.033848856,
0.016138794,
0.023529084,
-0.01733722,
-0.02801652,
-0.0004390065,
-0.031878114,
0.0011684647,
0.0042777127,
-0.022530396,
-0.012596781,
0.016285269,
0.0011052145,
0.011604751,
-0.023835348,
0.005456164,
-0.0062417984,
-0.018495698,
0.038109925,
0.033049908,
0.017896485,
-0.014128103,
-0.023742137,
-0.009381007,
0.018149486,
0.021758078,
-0.013002914,
-0.01209078,
-0.01701764,
0.012556834,
-0.024261454,
-0.013488943,
-0.030306844,
-0.018202748,
0.010859065,
-0.012643388,
0.011058803,
-0.00946756,
-0.012709966,
0.021039022,
-0.0064149043,
-0.029960632,
0.02655178,
-0.008622005,
0.015206685,
-0.008129318,
-0.00783637,
-0.0042777127,
0.015379791,
0.028415997,
0.028176311,
-0.026698252,
0.03243738,
0.022636922,
-0.015313213,
0.013954997,
-0.0067478004,
0.01145162,
-0.0022270738,
0.012543518,
0.0018625527,
0.016085532,
-0.041412253,
0.028549153,
0.007097341,
-0.006601326,
-0.010432959,
-0.027776835,
0.013861787,
0.028708944,
-0.029001893,
0.0028995236,
0.010566116,
0.015100159,
0.013076152,
0.005456164,
0.016604848,
0.0085887145,
0.004504082,
0.0033972028,
0.0065647075,
0.013928365,
-0.03659192,
0.011278514,
0.0041944887,
0.01519337,
-0.026445253,
-0.016618164,
0.019494385,
0.008808427,
0.01292302,
0.0020672837,
0.0067145107,
0.016804585,
-0.014660737,
-0.0027031149,
-0.0059022447,
-0.008921611,
-0.01724401,
0.007090683,
-0.039201822,
0.008721873,
-0.0032407418,
-0.0051665446,
0.009740534,
0.010346405,
-0.025499828,
-0.00072529697,
0.015126791,
0.014714,
0.027803468,
0.020706126,
-0.0120175425,
0.0016844533,
0.020719443,
-0.006185206,
-0.008841716,
0.00886169,
0.004966807,
0.007922923,
0.0019174805,
0.0037251054,
-0.6408646,
-0.012576808,
0.028469259,
-0.03898877,
0.012670019,
0.02050639,
0.0075167897,
0.01829596,
-0.013109442,
0.050360493,
-0.0248873,
0.004340963,
0.016937744,
-0.019188121,
-0.040986147,
-0.031425375,
0.002488397,
-0.018349223,
0.03267706,
0.0065647075,
0.0096073765,
-0.0012225603,
0.005695849,
0.0038982113,
0.009680614,
0.0037417503,
0.00084763626,
0.02091918,
0.011990911,
0.021824656,
-0.039814353,
0.012903046,
-0.018722067,
0.0054328614,
0.05025397,
-0.0068310243,
0.015086844,
0.025007142,
0.02376877,
0.027457256,
-0.006101982,
-0.023808716,
0.016391795,
0.026045777,
-0.01832259,
0.019973755,
-0.009227875,
-0.012883072,
-0.008768478,
-0.011884385,
0.0002925323,
0.024208192,
-0.021052338,
-0.013122757,
0.008735189,
-0.0000548238,
0.008921611,
-0.021105602,
0.027137676,
0.004257739,
0.00902148,
-0.014580841,
-0.023848664,
-0.021837972,
-0.0042810417,
-0.009101374,
-0.0055926517,
0.034061912,
-0.0130428625,
0.012949651,
0.014634104,
0.036405496,
0.014460999,
-0.017856536,
-0.0050367154,
0.01727064,
0.017949749,
0.030919373,
0.009434271,
0.027563782,
-0.009926956,
0.0022287383,
-0.032916747,
0.0007881311,
0.034354858,
0.006554721,
-0.03243738,
0.043516155,
0.005862297,
-0.020359915,
-0.0021155535,
-0.0030759582,
-0.023688873,
-0.027510518,
-0.025087036,
0.0353136,
0.0064115752,
0.025206879,
0.013375758,
-0.019947123,
-0.016018951,
-0.003585289,
0.023422558,
-0.009574086,
0.010899013,
-0.0033755647,
-0.010179957,
0.013808523,
0.042291097,
0.0007939568,
0.0046838457,
-0.02258366,
-0.0051132813,
-0.005050031,
-0.0050200704,
-0.022224132,
0.021198813,
0.00072238414,
0.0017035949,
-0.016551586,
0.010552801,
-0.016285269,
0.005289716,
-0.011944306,
0.006371628,
0.012916362,
-0.0014489295,
0.0007074038,
-0.0006978331,
-0.021265391,
0.008821742,
0.0179098,
0.014953685,
-0.018335907,
-0.0021305338,
0.005775744,
0.028788839,
0.017829906,
0.015140107,
-0.037018027,
-0.020013703,
-0.006594668,
0.0022304028,
-0.0046905037,
0.000874684,
-0.020999074,
-0.056991782,
-0.005476138,
0.01272994,
0.0030276885,
0.016644796,
0.011711279,
-0.0034521308,
0.0130295465,
-0.0063849436,
-0.006691208,
-0.018269328,
-0.019560965,
-0.021158865,
-0.011651358,
0.017963065,
-0.0020606257,
-0.022530396,
0.003189143,
-0.012903046,
-0.029694317,
0.010765854,
0.002210429,
-0.018495698,
-0.027004518,
0.0052730716,
-0.005722481,
-0.029268209,
0.012357096,
-0.006128614,
0.018162802,
-0.0077365013,
-0.003275696,
-0.009780482,
-0.021478444,
-0.010679301,
-0.025766144,
-0.019161489,
-0.012756572,
0.039974142,
0.016591532,
0.040160563,
0.018881857,
0.0075633954,
0.014234629,
-0.017403798,
-0.0007261292,
-0.015952373,
0.030440003,
0.0014572518,
-0.041731834,
0.008069397,
0.017204061,
-0.004014725,
0.027483888,
0.023782084,
-0.012962967,
-0.011251882,
-0.017257325,
0.010353063,
-0.030067159,
-0.0025666275,
-0.015779266,
0.0045806477,
-0.01317602,
-0.016298585,
-0.00537294,
0.013362442,
-0.022570344,
0.0071173147,
0.02632541,
-0.024314718,
0.013928365,
0.0030443333,
0.0034820912,
0.012177333,
-0.0043576076,
0.031585164,
0.015086844,
-0.0064814836,
0.001829263,
0.0029877408,
0.01327589,
0.02069281,
-0.021385234,
-0.012956309,
0.004021383,
-0.00077065406,
-0.0066146418,
-0.00018767007,
-0.0046738586,
0.0049401755,
-0.019747386,
0.030999267,
0.0050333864,
0.0026465226,
0.0003776288,
-0.0018558948,
-0.003924843,
0.0118311215,
-0.008755162,
0.010386352,
-0.0028029836,
0.0047737276,
0.0016852856,
-0.0063150357,
0.0033822225,
-0.023076346,
0.02139855,
0.005962166,
-0.028708944,
0.0052630845,
0.021252075,
0.045593426,
0.022730134,
-0.012150701,
0.011112066,
0.021505076,
-0.008888321,
0.012703309,
-0.013888418,
0.002033994,
0.011598094,
-0.028522523,
0.006125285,
-0.022463817,
-0.0055726776,
0.0046205954,
-0.01391505,
0.018415803,
0.0068376823,
0.0034887493,
0.029774211,
0.02258366,
0.0071506044,
-0.031052532,
-0.02530009,
0.027750203,
0.021891236,
-0.0011160335,
-0.015126791,
-0.030200318,
0.00006876382,
-0.014088156,
0.02181134,
0.003060978,
0.0008451395,
0.0050233994,
0.013002914,
-0.016738007,
0.010046799,
0.036405496,
-0.017536957,
0.010472906,
-0.025499828,
0.00876182,
-0.022969818,
-0.0064215623,
-0.009813772,
0.04247752,
0.026112355,
0.0031541889,
-0.004970136,
-0.003512052,
-0.012523545,
-0.0073836315,
0.02712436,
0.0034221702,
-0.01615211,
-0.012403702,
0.018149486,
-0.007350342,
0.013941681,
0.0018625527,
0.0033522618,
-0.024687562,
-0.035286967,
-0.012323807,
0.005313019,
0.040639933,
0.005556033,
0.010985565,
0.008235845,
-0.005715823,
-0.0011809483,
-0.016604848,
-0.009314428,
0.0396013,
-0.0013648733,
-0.0067444714,
-0.00495682,
-0.0047537535,
0.0138484705,
0.0008484685,
0.019747386,
0.0046672006,
-0.03768382,
-0.03326296,
0.0038516058,
-0.023249451,
-0.0033672422,
0.005229795,
0.024461193,
0.009341059,
-0.012483597,
0.013069494,
0.022410553,
0.019973755,
-0.03454128,
0.010725907,
0.029960632,
0.023076346,
0.016405111,
-0.03166506,
-0.033209696,
0.02210429,
0.0021288695,
0.014221313,
-0.00546948,
0.0091945855,
0.0009038124,
0.008821742,
0.009727219,
0.008415609,
-0.0032640444,
-0.003658526,
0.030040529,
-0.017204061,
-0.0077298433,
-0.008109345,
-0.024740824,
0.0074568684,
-0.023595663,
0.012603439,
-0.015153422,
0.0067211688,
-0.017776642,
0.0019208095,
-0.02958779,
-0.024767457,
-0.0050899787,
0.013162705,
-0.012077464,
-0.0089549,
-0.02894863,
-0.033848856,
-0.025513144,
-0.014101471,
-0.031878114,
0.01852233,
-0.033982016,
-0.03454128,
-0.0045839767,
0.038855612,
0.018202748,
0.015552898,
-0.011950963,
0.0029527869,
0.008282451,
-0.017057586,
-0.0071972096,
0.013488943,
-0.030093791,
-0.0026531804,
0.009520823,
-0.011744568,
0.0076566064,
-0.010326431,
-0.0029028524,
-0.0031691692,
-0.009933614,
0.01733722,
0.0073237102,
0.0010369708,
0.021292023,
0.011651358,
0.04647227,
0.01487379,
0.0020972444,
-0.0033855515,
-0.035659812,
-0.026618358,
-0.025499828,
-0.00044649665,
-0.017989695,
-0.0055094273,
-0.0077231852,
-0.018642172,
-0.010685959,
0.015100159,
-0.0130362045,
-0.022876607,
-0.0073703155,
0.0130295465,
0.01733722,
-0.011697963,
0.018788645,
-0.016644796,
-0.0046905037,
-0.008562083,
-0.016032267,
0.026618358,
0.007756475,
-0.019041646,
0.020093597,
0.010199931,
-0.031718325,
-0.0030426688,
-0.008894979,
-0.010166641,
0.033928752,
0.0034121831,
-0.025433248,
-0.014527578,
-0.00029211616,
-0.005732468,
-0.004111265,
0.013662049,
-0.011717936,
-0.0056658885,
0.008841716,
0.020493073,
-0.022876607,
0.0053929137,
-0.031691693,
-0.007170578,
-0.007863002,
-0.026924621,
0.01772338,
-0.0054262034,
-0.014141419,
0.008002818,
-0.0077831065,
-0.015366476,
-0.046818484,
0.0079828445,
-0.014034892,
0.045140687,
0.038855612,
0.046738587,
0.005229795,
-0.0076898956,
0.028575785,
0.020852601,
-0.0038948823,
0.0112185925,
0.0003901124,
-0.01644506,
0.006321694,
-0.0007540093,
-0.0036085919,
0.00047479282,
-0.01173791,
-0.010765854,
0.020879231,
0.0019457766,
-0.027483888,
0.0011351751,
-0.042051412,
-0.008329056,
-0.0022953174,
-0.02657841,
0.004164528,
-0.030040529,
0.002040652,
0.014767263,
-0.0075500794,
0.019347912,
-0.011345093,
0.03914856,
0.013715312,
0.019174805,
0.002370219,
0.011285172,
-0.0075500794,
-0.0074568684,
-0.0052597555,
0.0056758756,
0.03038674,
-0.0069908146,
0.038376242,
-0.0010918987,
0.004913544,
0.002440127,
-0.014967001,
-0.02098576,
-0.014620789,
-0.011950963,
-0.010639354,
-0.0036052628,
-0.008941584,
-0.013608785,
-0.03307654,
-0.010859065,
0.013515575,
-0.009361033,
0.028202942,
-0.0010361385,
-0.003938159,
0.03685824,
-0.0072171837,
0.008848374,
-0.018375855,
0.021505076,
0.015126791,
-0.0011393363,
-0.023622295,
-0.02012023,
0.008721873,
-0.019760702,
0.03560655,
-0.008615347,
-0.015433055,
-0.020066965,
-0.013821838,
-0.021438498,
-0.01877533,
-0.028549153,
-0.009094717,
-0.029188314,
0.01647169,
-0.0014971994,
0.022250764,
-0.009926956,
-0.0058989157,
-0.008269135,
0.025899302,
-0.010958934,
-0.0070773675,
-0.030626426,
-0.007809738,
0.0034587886,
0.020572968,
0.001919145,
-0.0100068515,
0.011411672,
0.006378286,
0.0014897092,
-0.00204731,
0.008675268,
0.03267706,
0.0063882726,
0.00767658,
0.013994944,
0.021904552,
0.0073836315,
-0.0043609366,
0.0058290074,
0.041651938,
-0.00537294,
-0.018375855,
0.020146862,
0.020080281,
0.012656703,
-0.006631287,
-0.018815277,
-0.011724594,
-0.03834961,
0.010033483,
0.018216064,
0.024328034,
0.0044541475,
-0.007809738,
-0.021185497,
0.0118977,
-0.021278707,
-0.025499828,
0.024780773,
-0.026365357,
-0.011072119,
-0.008402293,
0.030786214,
0.011857753,
0.019933809,
0.0034754334,
0.0005397075,
0.024021769,
-0.019774018,
0.02894863,
0.013136073,
-0.0056026382,
-0.015712688,
0.01772338,
-0.031744957,
-0.038136557,
0.008009476,
-0.0026681607,
-0.022090973,
-0.000992862,
-0.0093943225,
0.01727064,
0.011504883,
-0.021265391,
0.0047138063,
0.0038050003,
0.017736694,
0.016884482,
-0.014394419,
0.008455557,
-0.015979005,
0.0075567374,
0.0050034258,
0.00095041783,
-0.0029993923,
0.00457399,
-0.021771394,
0.009454244,
-0.0019208095,
-0.0038149874,
-0.01829596,
-0.0102998,
0.0067311553,
0.011538173,
-0.010060115,
0.0010902341,
-0.022423869,
0.025220195,
-0.010626038,
-0.0004976794,
-0.0068976036,
-0.0025882658,
-0.013741944,
-0.00010652669,
-0.014993632,
0.014434367,
0.02251708,
-0.039867617,
-0.042823732,
0.020612916,
-0.0060653635,
0.037763715,
0.020932496,
-0.026019145,
-0.018602224,
0.018469065,
-0.039334983,
-0.017630167,
0.00975385,
0.0069308933,
0.007496816,
0.023848664,
-0.0071439464,
0.0024018441,
-0.014594157,
0.014767263,
0.013455654,
-0.029321473,
0.010446274,
-0.013189336,
0.014048208,
0.01644506,
-0.02568625,
-0.0033722357,
0.03198464,
-0.012330465,
-0.011178645,
0.025885986,
0.013795207,
0.044395,
-0.013688681,
-0.009234533,
-0.029214947,
0.024927247,
0.023196189,
-0.029987264,
-0.0013582153,
0.0073303683,
0.004111265,
-0.036352236,
0.014407735,
0.0052664136,
0.016178742,
0.0032440708,
-0.018575592,
-0.03182485,
0.0031758272,
-0.014434367,
0.011944306,
0.002127205,
0.006764445,
0.02376877,
0.011970937,
-0.010432959,
-0.020612916,
-0.03070632,
-0.009827088,
-0.018788645,
0.0077098696,
-0.010026826,
-0.004557345,
0.0019091581,
-0.009081401,
-0.01909491,
0.00040176377,
-0.004384239,
-0.016804585,
-0.014753947,
0.00978714,
0.0027480558,
-0.013981629,
0.01327589,
0.0015770944,
-0.01244365,
0.002530009,
0.0026298778,
0.00115182,
-0.03323633,
-0.0096073765,
0.009061427,
0.008768478,
0.019587597,
-0.0058057047,
-0.02459435,
-0.025206879,
0.01633853,
0.17289282,
-0.020586284,
-0.0029894053,
0.008109345,
-0.009680614,
-0.011464936,
-0.013688681,
-0.013768575,
-0.007257131,
0.00089382555,
0.03629897,
0.009747192,
-0.024447877,
-0.0037650529,
0.0117712,
-0.0030360108,
-0.022051025,
-0.017856536,
-0.012337123,
0.0062151668,
0.0050300574,
-0.0010328096,
-0.009700587,
-0.012450308,
0.033768963,
0.0030942676,
-0.01842912,
0.00081268215,
-0.03297001,
0.008448899,
-0.024447877,
-0.0065613785,
0.00786966,
0.009514165,
0.007863002,
0.01644506,
-0.0007061555,
-0.004154541,
-0.0034488018,
-0.01822938,
0.013302521,
0.012656703,
-0.006764445,
-0.009640666,
0.016205374,
0.010486222,
-0.000060233357,
-0.024953878,
-0.011584778,
0.014927053,
-0.02641862,
-0.0014148076,
-0.0061186273,
0.04026709,
0.004064659,
0.003179156,
-0.0021405208,
0.014327841,
-0.013575496,
0.027324097,
-0.024194876,
0.007929581,
-0.024407929,
0.018482381,
-0.01804296,
0.010432959,
-0.0067944056,
0.016045583,
0.013222626,
-0.012683335,
-0.0008863354,
0.013688681,
-0.008415609,
-0.0015571207,
-0.0030759582,
-0.022943188,
0.036245707,
0.0205996,
0.035686444,
0.013249258,
0.012650045,
0.0038582638,
-0.04356942,
0.012510229,
-0.006441536,
-0.019015014,
0.026112355,
-0.006138601,
-0.026298778,
-0.0014622454,
0.013076152,
-0.007257131,
-0.010879039,
-0.0015396436,
-0.00028358572,
-0.02149176,
-0.03201127,
-0.0023086332,
-0.015952373,
-0.0041778437,
-0.030759582,
0.08447567,
-0.0043675946,
0.033129804,
-0.00767658,
0.008109345,
0.009966904,
0.009128006,
-0.00021367757,
-0.005286387,
0.022889923,
0.007183894,
0.013575496,
-0.00053679466,
-0.009321086,
0.015313213,
0.0047970302,
-0.029001893,
0.03707129,
-0.000978714,
0.0056092963,
-0.01653827,
-0.014980316,
0.023462504,
0.010672643,
0.011684647,
0.00077065406,
0.00039760256,
0.0031258927,
-0.037630554,
0.0013141066,
0.011484909,
0.0010835762,
0.014381104,
0.008708557,
-0.023222819,
0.0029527869,
-0.014500947,
-0.0112119345,
0.013409047,
0.0045340424,
-0.007849686,
0.011911016,
0.02053302,
-0.0003064723,
-0.019334596,
0.020053651,
0.03403528,
0.005652573,
-0.007350342,
-0.013156047,
0.011105408,
0.024407929,
-0.0018159472,
0.014620789,
-0.015206685,
-0.015273265,
-0.021957815,
-0.0037617239,
-0.007343684,
-0.023928558,
0.013821838,
0.019494385,
0.0038982113,
-0.0036252367,
0.007536764,
-0.16724691,
0.004817004,
0.011697963,
-0.022863291,
0.025646301,
0.024780773,
0.02910842,
0.017883169,
-0.0027963258,
-0.007909607,
-0.018535646,
0.017563589,
-0.030786214,
-0.046845116,
0.008042766,
0.015419739,
-0.016831217,
0.018575592,
0.01842912,
0.008875005,
-0.0001672802,
-0.01039301,
0.034754336,
-0.012703309,
0.015033579,
0.02331603,
0.017004324,
0.00010553841,
-0.02210429,
-0.007423579,
0.00071863906,
0.00045232233,
0.01592574,
-0.0069774985,
0.021039022,
-0.0013682023,
0.015220001,
0.011957621,
0.008369003,
0.019494385,
0.015899109,
0.031292215,
0.005599309,
0.0003206204,
-0.012942993,
0.021531709,
0.00044774503,
-0.0027963258,
0.019387858,
-0.012463624,
0.015646107,
-0.023009766,
0.02306303,
0.018242696,
0.019774018,
-0.02037323,
-0.013861787,
0.031798217,
-0.016112162,
-0.0088017685,
-0.0039914222,
-0.015086844,
0.03259717,
0.0021821328,
-0.02258366,
-0.023236135,
-0.020586284,
0.01093896,
-0.027803468,
-0.004470792,
0.002248712,
-0.004783714,
-0.017323904,
0.016365163,
0.02625883,
0.0055926517,
-0.0062983907,
-0.0034521308,
0.003751737,
-0.013342469,
-0.009454244,
0.0013615444,
-0.033209696,
-0.03336949,
-0.0033223012,
-0.01292302,
-0.01241036,
0.025606355,
-0.015939057,
0.012610097,
0.020586284,
-0.027430624,
0.038243085,
-0.010426301,
0.033049908,
0.02197113,
0.017510325,
-0.0065780235,
-0.008135976,
0.011891042,
0.008142634,
-0.027696941,
-0.0132426,
0.019281331,
0.02801652,
0.010213247,
0.0071639204,
0.00831574,
0.038429506,
-0.021425182,
-0.023182873,
-0.0077098696,
0.014314525,
0.03864256,
-0.0063350094,
0.027257519,
0.011458278,
-0.002082264,
-0.0033589199,
-0.015006948,
0.074408896,
0.017763326,
-0.0062417984,
-0.0026781477,
-0.016405111,
-0.018096222,
-0.14221314,
-0.014207998,
0.009460902,
0.024261454,
-0.008755162,
0.011671331,
-0.008455557,
0.019880544,
-0.022423869,
0.03342275,
-0.03563318,
-0.011358409,
0.0018242697,
-0.018349223,
-0.009780482,
-0.003522039,
0.01407484,
-0.018122854,
-0.028389364,
0.029161682,
-0.0021754748,
0.002012356,
-0.0023003109,
-0.00331065,
0.004377581,
0.011118724,
-0.03297001,
0.03323633,
0.012137385,
-0.008162608,
0.0017427101,
-0.023502452,
-0.0061752195,
-0.0099935355,
-0.022650238,
-0.0045440295,
0.005133255,
-0.029454632,
0.05262419,
0.0070773675,
-0.0030043856,
0.005785731,
0.016964376,
0.007536764,
0.00019214336,
-0.016658112,
-0.003234084,
0.011225251,
-0.008016134,
-0.0006279249,
-0.029454632,
-0.0070773675,
-0.033183064,
-0.01487379,
0.027803468,
0.0013781891,
-0.0003564067,
0.015140107,
-0.020639548,
0.010253195,
-0.020186808,
-0.003515381,
-0.02203771,
-0.00038511897,
0.018056275,
-0.01980065,
-0.02347582,
-0.02290324,
0.052757345,
-0.026658306,
0.008255819,
-0.0072238417,
-0.0058556395,
0.007090683,
-0.028575785,
0.018402487,
-0.03629897,
-0.019694123,
0.019374542,
-0.014474315,
-0.013156047,
-0.020812653,
0.018895173,
-0.03483423,
0.043303102,
0.015686056,
-0.009687271,
0.0059355344,
0.020706126,
-0.0023968506,
-0.021505076,
0.051958397,
-0.009647324,
-0.025193563,
0.01599232,
0.013349126,
0.0015163409,
-0.0076100007,
0.022849975,
0.029428,
-0.022836661,
-0.008994848,
-0.03712455,
0.007916265,
0.023422558,
-0.0060320743,
0.016738007,
-0.01852233,
0.013429021,
0.016325217,
0.007450211,
0.0008788452,
-0.036884867,
0.008502162,
-0.012317149,
-0.011598094,
-0.00985372,
-0.024541087,
0.024035085,
-0.0029727605,
0.0176568,
0.018562276,
-0.006634616,
-0.007443553,
0.021917868,
0.008528793,
-0.0009487534,
-0.0083956355,
-0.025566407,
0.0011726259,
0.005366282,
0.0022437186,
-0.004424187,
-0.033183064,
-0.0051032943,
0.0024800745,
-0.016884482,
-0.032197695,
-0.009880351,
0.022157552,
0.026285462,
0.022410553,
-0.03246401,
-0.035073914,
-0.01218399,
-0.014261262,
-0.00025965882,
0.0053596245,
-0.050200704,
-0.008335714,
0.0010844085,
-0.030280214,
0.025672933,
0.011724594,
-0.0031009256,
-0.03249064,
-0.03502065,
0.0022470474,
-0.011358409,
-0.029294841,
0.0065613785,
-0.02030665,
0.014460999,
0.008841716,
0.021678183,
-0.011598094,
0.0012824816,
0.009094717,
-0.015220001,
-0.0056825336,
-0.0010918987,
-0.010945618,
-0.020479757,
0.016684745,
0.025033774,
-0.019534333,
0.0038283032,
-0.023622295,
-0.023489136,
-0.0042743837,
-0.00014345734,
0.007190552,
0.024913931,
-0.01010672,
0.010892355,
0.033795595,
0.028069785,
-0.004427516,
-0.01551295,
0.0029477933,
0.014034892,
-0.014434367,
-0.006378286,
0.01228386,
0.0033289592,
0.023968507,
-0.0064215623,
0.016365163,
-0.013222626,
-0.0008696906,
0.0005680037,
0.03137211,
0.004107936,
-0.002664832,
0.0026082397,
-0.01902833,
-0.0063117067,
0.03070632,
-0.028043153,
-0.034461387,
0.006371628,
-0.015859162,
-0.0059754816,
-0.014887106,
-0.028735576,
0.008968216,
-0.0065680365,
0.026858043,
-0.0032707024,
-0.028495891,
-0.015899109,
0.030120423,
0.015286581,
-0.01241036,
-0.006441536,
-0.006528089,
0.02530009,
0.011311803,
0.024381297,
-0.019667491,
0.025606355,
-0.010506195,
0.018881857,
0.00077689585,
-0.026218884,
-0.01621869,
-0.0047604116,
-0.009241191,
0.007430237,
0.014114787,
-0.010146667,
0.08266471,
0.013781891,
-0.002648187,
0.017590221,
-0.026471883,
0.03504728,
-0.002929484,
0.00866861,
-0.00085179746,
-0.033875488,
0.014221313,
-0.036778342,
0.02555309,
-0.0396013,
0.0049368464,
0.031744957,
-0.020799337,
0.010559458,
0.0008443073,
-0.019134857,
0.013475627,
-0.006454852,
-0.0098004555,
0.016405111,
-0.014780579,
0.0060653635,
0.018828593,
0.0018725395,
0.0064382073,
-0.0031508598,
-0.009673956,
-0.0022170867,
-0.0310259,
0.00505336,
0.023995139,
0.0051232683,
-0.011078776,
0.004840307,
0.002523351,
0.011797831,
0.010739222,
0.014434367,
0.006727827,
-0.002644858,
0.0023752125,
0.006265101,
-0.018415803,
-0.010672643,
0.010133352
] |
Background Current criteria for the selection of unrelated donors for hematopoietic cell transplantation (HCT) include matching for the alleles of each human leukocyte antigen (HLA) locus within the major histocompatibility complex (MHC). Graft-versus-host disease (GVHD), however, remains a significant and potentially life-threatening complication even after HLA-identical unrelated HCT. The MHC harbors more than 400 genes, but the total number of transplantation antigens is unknown. Genes that influence transplantation outcome could be identified by using linkage disequilibrium (LD)-mapping approaches, if the extended MHC hap | [
-0.013593472,
-0.0015201885,
0.020346096,
-0.035262946,
0.0037665386,
0.015636226,
-0.0025975544,
0.012127575,
-0.039172,
-0.006145227,
-0.0074652117,
-0.009141491,
0.001762808,
0.0065184874,
0.0010349498,
0.0059144837,
0.03480146,
-0.005928057,
-0.008883602,
-0.008944681,
-0.03214113,
0.0055683693,
-0.012779085,
-0.0066542183,
-0.005833045,
0.03925344,
0.038846247,
-0.043271083,
-0.0068985345,
-0.020359669,
0.008496768,
-0.0044621606,
-0.02455376,
0.0025313855,
-0.0046420046,
-0.011611798,
0.025856778,
-0.015229032,
0.029453654,
0.013417021,
0.015283325,
0.019830316,
0.0024567333,
-0.008503554,
0.0110553,
0.008836096,
-0.020698996,
-0.028449243,
-0.019260246,
0.0249881,
0.021689834,
0.0011554111,
-0.0049236463,
0.015459775,
-0.009012546,
-0.0062164855,
0.019871036,
0.012290454,
0.0081778,
-0.019029504,
0.003332199,
-0.0059110904,
-0.01578553,
0.009983024,
-0.025965365,
0.0070715914,
-0.014753973,
-0.00088564557,
0.0053003,
0.007634876,
0.03143533,
0.0020546298,
0.004343396,
0.0032473672,
0.023087865,
-0.016260589,
-0.0035425823,
-0.013152346,
-0.0071123107,
0.0029199158,
0.021431943,
-0.02555817,
0.005768573,
0.027770588,
0.014034598,
0.015514067,
0.017740058,
-0.005072951,
0.009589404,
-0.011150312,
0.00389209,
0.0074041327,
0.015229032,
0.013118413,
0.009949091,
-0.00391245,
0.029372215,
0.024865942,
0.031272452,
-0.024933808,
-0.021160481,
0.017943654,
-0.013036975,
-0.017360011,
-0.03672884,
0.00043412752,
0.016464185,
-0.001983371,
0.00348829,
0.0011350515,
-0.014238195,
0.024689492,
-0.0098201465,
-0.03091955,
0.0068612085,
-0.019138088,
0.011313189,
0.00552765,
-0.01367491,
-0.0037156395,
0.04033929,
0.022164892,
-0.008571421,
-0.0188802,
0.0377604,
0.020332523,
-0.01708855,
0.0033305024,
-0.022205612,
-0.0020376635,
0.016233442,
0.002105529,
0.004353576,
0.017875789,
-0.029372215,
0.010973861,
-0.03385134,
-0.0053308397,
-0.011435347,
-0.036973156,
-0.0037868982,
0.0366474,
-0.0024635198,
-0.002575498,
-0.011184244,
0.0060366415,
0.029317923,
0.008686792,
0.012439758,
0.0027621284,
-0.0022819794,
0.0035120428,
0.017332865,
-0.019640293,
0.011808608,
0.008795377,
0.0030318939,
0.019178808,
-0.0038038648,
-0.012378679,
-0.017169988,
-0.024865942,
0.019165235,
0.006386149,
0.003167625,
0.011971485,
-0.014251768,
0.013654551,
0.006297924,
-0.022097027,
-0.0028520501,
0.030648088,
-0.019165235,
0.0042755306,
0.0026348804,
0.006019675,
0.016939243,
0.007858832,
-0.058635846,
-0.030810965,
-0.013668124,
0.017672192,
0.030295186,
0.0156498,
-0.016464185,
0.007356627,
0.008476408,
-0.009888012,
-0.0070580184,
-0.028937876,
-0.013457741,
0.00041037457,
0.003759752,
-0.016301308,
-0.6306611,
-0.0039463826,
0.011795035,
0.003464537,
0.014835412,
0.02302,
0.029019315,
0.0019188988,
-0.019070223,
0.02333218,
-0.015758384,
0.028069196,
0.024228005,
-0.02825922,
-0.0029131293,
-0.036430232,
-0.0025212057,
-0.024377309,
0.033226978,
0.0123515325,
0.0020529332,
-0.0024550366,
-0.01744145,
0.010105182,
-0.01927382,
0.012880883,
0.021988442,
0.0067322636,
-0.020563265,
0.0076552355,
-0.0023702048,
0.0029385788,
-0.037868984,
0.003342379,
0.058201507,
0.014781119,
-0.007831686,
0.026766177,
-0.0050593778,
0.0015278234,
0.00039680145,
-0.023820812,
0.02189343,
0.0077638202,
-0.012141149,
0.026263973,
0.005127243,
-0.0060705743,
0.008089575,
-0.015066154,
0.0019664047,
0.0221106,
-0.015704092,
0.007723101,
0.0033288058,
-0.024730211,
0.039932095,
-0.015690519,
0.023359327,
0.0017831676,
-0.0033966713,
0.011292829,
-0.0064981277,
-0.020875446,
0.011693236,
-0.016382746,
-0.011442133,
0.006528667,
0.016613489,
-0.00021886644,
-0.004770949,
0.034720022,
-0.014726827,
-0.0011503212,
0.012908029,
0.011822181,
-0.004794702,
-0.007831686,
-0.013036975,
0.03995924,
-0.009718348,
-0.0032253107,
0.00072191993,
0.0054462114,
0.04156087,
-0.017645046,
-0.030322332,
0.022368489,
0.0167085,
0.02268067,
0.0046759374,
0.0145232305,
-0.01203935,
-0.04837457,
-0.0076077296,
0.014767546,
-0.0266033,
-0.0010459779,
0.01208007,
-0.026576154,
0.0021174054,
-0.01556836,
0.0049236463,
0.016952816,
0.021839138,
0.009480819,
-0.03474717,
0.00042840134,
0.03672884,
-0.02459448,
-0.012134362,
-0.005602302,
-0.008584994,
0.010315565,
0.033742756,
-0.013206638,
-0.0023854745,
-0.00087546575,
0.005049198,
-0.033335563,
0.04337967,
0.011577865,
-0.0119171925,
-0.026019657,
0.01653205,
0.00800135,
-0.00042606847,
-0.027295528,
0.016735647,
0.0039226296,
0.015188312,
-0.013640977,
0.024662346,
-0.024132993,
0.03214113,
-0.011347122,
0.018866627,
0.0071462435,
0.0042551705,
-0.021309786,
-0.022015588,
-0.009284009,
0.021350505,
-0.0061588,
-0.017115695,
-0.0043637557,
-0.011462493,
-0.023182876,
0.0040176413,
-0.0366474,
-0.00085595436,
-0.0068035224,
-0.03501863,
-0.0011588045,
-0.008014923,
-0.003060737,
-0.0035290092,
-0.01927382,
0.005843225,
-0.031109573,
-0.006878175,
0.017251426,
-0.00613844,
0.016247015,
-0.012046137,
-0.015839823,
-0.009575831,
0.016287735,
-0.0017797743,
-0.022816401,
0.010254486,
-0.025341,
-0.0075873695,
0.018785188,
-0.0070240856,
-0.008707152,
-0.0016618579,
-0.005639628,
0.009643696,
0.0015490315,
-0.0039192364,
-0.019423123,
-0.008184587,
-0.02289784,
0.0054122787,
0.0201425,
0.007444852,
0.007750247,
0.0040549673,
0.02538172,
-0.018893773,
0.007139457,
-0.030648088,
0.009019333,
0.0018187971,
0.018635884,
0.014197475,
0.011476066,
0.008062429,
0.025096685,
0.0204954,
-0.01375635,
0.018242262,
-0.0031710183,
0.021486236,
-0.030892404,
-0.006409902,
0.00097556744,
0.00016584646,
-0.0048761405,
-0.010580241,
-0.010573454,
0.004696297,
-0.010824557,
0.004954186,
0.007648449,
-0.030403772,
0.0039735287,
-0.008313531,
-0.007281975,
0.004489307,
0.02790632,
0.014794692,
-0.006321677,
0.0077163144,
-0.010770265,
0.007594156,
-0.005147603,
-0.008761444,
-0.024228005,
-0.0116321575,
-0.0021852711,
-0.00009999566,
-0.007051232,
0.009365448,
-0.0011689843,
0.0008907355,
-0.007940271,
0.024838796,
0.0028791965,
-0.0052901204,
0.013288077,
0.005402099,
0.011387841,
-0.004112653,
-0.024580907,
0.0095351115,
-0.021621969,
-0.022694243,
0.026155388,
0.005035625,
0.0016135037,
-0.013525606,
-0.024390882,
0.004085507,
-0.0275127,
0.009446886,
0.012378679,
0.02782488,
0.01103494,
0.018242262,
-0.0018340668,
-0.025395293,
-0.025883924,
-0.0040346077,
0.005690527,
0.0026722064,
-0.018690176,
-0.006274171,
0.012229375,
-0.0095351115,
-0.01395316,
0.011204604,
-0.031462476,
0.009148277,
0.03947061,
0.019314539,
-0.0018544265,
0.0142246215,
-0.009799787,
-0.011367481,
-0.021621969,
0.03501863,
0.042320963,
-0.021567676,
-0.0028266006,
-0.012046137,
-0.005805899,
-0.00553783,
0.027580565,
0.009942304,
-0.005225648,
0.020970458,
-0.008333891,
0.015337617,
-0.026440423,
0.03178823,
0.013199852,
0.0023719014,
-0.020074634,
-0.0043603624,
-0.0005234131,
-0.04270101,
-0.028286366,
0.025585316,
0.02991514,
-0.016043419,
-0.020821154,
0.013980306,
-0.019586,
-0.017468596,
0.0011562594,
0.015799103,
-0.010091609,
-0.002612824,
0.017902935,
-0.0029487587,
0.043271083,
0.010349498,
-0.0026840828,
0.000028683804,
-0.031733938,
-0.010369858,
-0.0048659607,
0.03056665,
0.008347464,
-0.017210707,
0.028720705,
-0.009433313,
-0.0010018654,
0.0050016916,
-0.023793666,
0.024363736,
0.004085507,
-0.014292487,
-0.007770607,
0.015283325,
0.015514067,
0.009406167,
0.03550726,
0.01966744,
-0.01814725,
-0.02272139,
0.011007794,
-0.005391919,
-0.030458065,
0.01984389,
0.03070238,
0.016694928,
0.0057482133,
0.004944006,
0.006311497,
-0.006443835,
-0.0015838125,
-0.029779408,
0.010627747,
0.0019053257,
0.015120447,
-0.0075737964,
-0.005347806,
0.0073634135,
0.013165919,
0.017685765,
0.0064166887,
0.02847639,
0.019748878,
0.003233794,
0.01369527,
0.015052581,
-0.0152426055,
-0.0065320604,
-0.0020461467,
-0.0052561876,
-0.015771957,
0.03531724,
-0.029426508,
-0.0018171004,
-0.006396329,
0.018106531,
-0.004682724,
-0.0183237,
0.008435689,
0.008428902,
0.00051280914,
-0.007723101,
-0.037706107,
0.011530359,
0.0005955203,
-0.019205954,
-0.0042653508,
-0.025883924,
-0.02158125,
-0.021947723,
-0.017984373,
-0.0066168923,
0.008951467,
-0.011537146,
-0.0059484164,
0.007078378,
-0.012521196,
0.028965022,
-0.003243974,
0.010349498,
0.023698654,
-0.027566992,
-0.00064854027,
0.008456049,
-0.02197487,
0.027987758,
-0.001927382,
0.007662022,
0.015052581,
-0.020766862,
0.026711885,
-0.017278573,
-0.011306402,
-0.0021275852,
0.02682047,
0.003929416,
0.012093643,
0.022097027,
0.008557848,
-0.03257547,
-0.025544597,
-0.0041092597,
-0.0435154,
-0.033688463,
-0.010736331,
0.0074652117,
-0.023644362,
-0.0008746174,
-0.014238195,
0.009867652,
-0.021431943,
0.03624021,
-0.031625353,
0.01286731,
-0.0044078683,
0.02477093,
0.019002357,
0.012310813,
0.0024991492,
0.0017882575,
-0.022097027,
-0.0034390874,
-0.027159797,
0.02934507,
0.010397004,
-0.016613489,
0.0027061393,
0.008299958,
-0.023033572,
-0.001983371,
-0.018758042,
0.0007588218,
0.041968063,
0.019613147,
0.004051574,
-0.016206296,
-0.019599574,
0.019938901,
0.037841838,
0.0042755306,
-0.007831686,
-0.0005289272,
0.0122022275,
0.005541223,
-0.021621969,
0.00060951756,
-0.03493719,
-0.025748193,
0.022762109,
0.015486921,
-0.01229724,
0.0021377653,
0.00880895,
-0.015473348,
-0.017943654,
-0.013776709,
-0.028204927,
0.0070987376,
-0.019070223,
0.055921223,
0.025626035,
0.025341,
-0.011890046,
0.016247015,
0.025218843,
0.014726827,
0.009657269,
-0.017305719,
0.020766862,
0.00030221383,
-0.0006595684,
0.014781119,
0.018432286,
-0.009195783,
-0.006409902,
0.02882929,
0.015758384,
-0.008401756,
-0.034910046,
-0.0025704082,
-0.049786177,
-0.01205971,
0.014604669,
-0.0027926678,
-0.0030115342,
-0.03637594,
0.003987102,
0.0023277889,
-0.014455365,
-0.009664056,
-0.014686108,
0.03651167,
-0.011374268,
0.00552765,
-0.0021360687,
0.0035188294,
0.0028418703,
-0.0045503858,
-0.0086325,
-0.008320318,
0.010736331,
0.0076688086,
0.014021025,
0.03550726,
-0.031191012,
0.009460459,
0.0028927696,
-0.050356247,
-0.0122022275,
-0.023400046,
-0.02721409,
0.007356627,
0.004248384,
-0.019871036,
-0.019898182,
-0.0019307752,
0.0038106514,
-0.008700365,
0.022409208,
0.0035324025,
-0.032168277,
0.012066497,
0.005700707,
0.018690176,
-0.037787545,
0.03602304,
0.013098054,
-0.012534769,
-0.035968747,
-0.008971827,
0.01613843,
0.02010178,
0.011116379,
0.015894115,
-0.0055683693,
-0.0061146873,
0.025286708,
0.0030895798,
-0.017997947,
-0.038357615,
-0.0009908372,
0.018473005,
0.0038411908,
0.0012809625,
-0.0212012,
-0.01513402,
-0.00035756666,
0.022422781,
0.010078036,
-0.00032914797,
-0.008347464,
0.004530026,
0.011516786,
-0.024309443,
-0.0127112195,
0.008266025,
-0.003661347,
-0.0022989458,
-0.033797048,
-0.021377651,
0.010654893,
0.010458083,
0.023074292,
0.0063386434,
-0.00077960565,
0.0018510332,
0.0023210023,
0.021174055,
-0.028096342,
-0.0074652117,
0.040882215,
-0.015310471,
-0.003243974,
0.014441791,
0.013165919,
0.0061927326,
0.0016745827,
-0.006016282,
0.0087410845,
-0.027553419,
-0.018676603,
0.013640977,
0.014713254,
-0.004567352,
0.013702056,
-0.021649115,
-0.024309443,
-0.04012212,
-0.039877802,
0.038086154,
-0.03510007,
0.013600258,
0.010492016,
0.012555129,
0.010376644,
0.0044825203,
-0.0012818108,
-0.0150933005,
0.029182192,
-0.020033915,
0.036403086,
0.02477093,
0.017916508,
-0.0294808,
0.0011749226,
-0.014034598,
-0.026698312,
0.020251084,
-0.0062504183,
-0.017509315,
0.00102477,
0.006467588,
0.0016847625,
-0.0021377653,
-0.016586343,
0.0012029171,
-0.0000020545237,
0.03572443,
0.0025788913,
-0.006623679,
0.028123489,
-0.026589727,
-0.012337959,
0.003817438,
0.00089921866,
0.01980317,
-0.010363071,
-0.0040481808,
-0.02102475,
-0.026155388,
-0.016056992,
-0.0054088854,
0.020685423,
0.0005119608,
0.012453331,
-0.03026804,
-0.032113984,
-0.021811992,
0.0077434606,
0.005768573,
-0.015690519,
0.023630789,
-0.0010807591,
-0.016952816,
0.046202876,
-0.015894115,
0.025463158,
0.0005823714,
-0.012012204,
-0.046800092,
0.018907346,
-0.0071937493,
0.043596838,
-0.002429587,
-0.00019829469,
-0.011733956,
0.006515094,
-0.052175045,
-0.013898867,
0.028150635,
0.009012546,
0.002673903,
0.023467911,
0.00057388813,
0.011306402,
-0.010865277,
0.020997604,
0.0068883547,
-0.0021072256,
0.014862558,
0.008958254,
0.031733938,
0.022924986,
-0.056898486,
-0.021811992,
0.015405483,
0.008836096,
-0.0022361702,
0.023956543,
-0.0013827608,
0.048537448,
-0.015459775,
0.0077163144,
-0.027458407,
-0.0031761082,
-0.022246331,
-0.014821839,
-0.0035833016,
0.0043841153,
-0.008998973,
-0.0019681014,
-0.007634876,
-0.00031112117,
0.012575489,
0.0045843185,
-0.008171014,
-0.026413277,
0.022259904,
-0.021038324,
-0.01395316,
0.0031099394,
-0.019002357,
0.019531708,
0.008048856,
0.010261273,
-0.0004797247,
0.002833387,
0.007003726,
-0.013070907,
-0.011333548,
0.008293171,
0.009148277,
-0.0041669453,
0.0026705097,
-0.024200859,
0.0021174054,
0.008014923,
-0.027879173,
-0.020156072,
0.01674922,
0.0028775,
-0.005286727,
0.014821839,
0.0020088207,
-0.019165235,
-0.0246352,
-0.0019409551,
-0.0013581596,
-0.020821154,
0.0012122486,
-0.01631488,
-0.015025435,
-0.027444834,
-0.001104512,
-0.029535092,
-0.023006426,
0.004879534,
0.19621292,
-0.026345411,
0.004136406,
-0.011543932,
0.0025415653,
-0.017387157,
0.038791955,
-0.0019426517,
0.0032643336,
0.015554787,
0.015500494,
-0.0038106514,
-0.0068442416,
-0.0026280938,
0.009555471,
-0.020644704,
-0.04465554,
-0.009772641,
-0.021730553,
-0.0023006424,
-0.013131986,
0.020780435,
-0.008903962,
-0.03349844,
0.032656908,
0.007600943,
0.012127575,
0.01596198,
0.0068747816,
-0.0032592437,
-0.018785188,
-0.010763478,
-0.010844917,
0.0071326704,
0.007987777,
0.005137423,
-0.013328796,
-0.0020665063,
0.0062436317,
0.014658961,
-0.0062639914,
0.012941962,
-0.0042653508,
0.011360695,
0.016912097,
0.03070238,
0.012310813,
-0.012928389,
-0.008313531,
-0.021784846,
-0.03257547,
0.0043128566,
0.001722937,
0.026236827,
-0.0127112195,
0.0036647404,
0.036620256,
0.002896163,
-0.012819804,
0.009060052,
0.004177125,
0.0044723405,
-0.031082427,
0.037950423,
-0.00095690443,
0.037651815,
-0.026440423,
-0.011523573,
0.01005089,
-0.01883948,
0.0033661318,
-0.011835754,
-0.00055692176,
-0.0028588367,
0.0035697285,
-0.009365448,
0.014550377,
0.02359007,
-0.0015278234,
0.0030183208,
-0.0019765845,
-0.013926013,
-0.01678994,
0.0055615827,
-0.008171014,
-0.013084481,
0.0320054,
0.02197487,
-0.020658277,
-0.00081947667,
0.011150312,
0.0008355947,
-0.0047132634,
-0.0019765845,
-0.008313531,
0.0085171275,
0.023250742,
0.0025279922,
-0.008937894,
-0.019287392,
-0.029589385,
0.06629108,
-0.006270778,
0.015948407,
-0.025083112,
0.021649115,
0.009888012,
0.011279256,
0.007634876,
-0.0010722759,
0.016830659,
-0.017943654,
-0.0030098376,
0.0020563265,
0.014075317,
0.030783819,
0.0058534048,
-0.04308106,
0.031543914,
-0.0016457399,
-0.00095351116,
-0.017875789,
0.008903962,
0.043406814,
0.016423466,
0.008055642,
0.006661005,
0.0023990476,
-0.019748878,
-0.035860162,
-0.0053749527,
-0.017685765,
-0.008659646,
0.010145902,
0.014781119,
-0.009548685,
-0.010525948,
-0.02717337,
-0.037570376,
0.008666432,
-0.00046827237,
-0.01330165,
0.022341343,
-0.005551403,
0.013926013,
-0.022816401,
0.008062429,
-0.0014938907,
-0.014333206,
-0.031978253,
-0.012242948,
-0.018608738,
-0.0067695896,
-0.01125211,
0.008130294,
-0.023997262,
-0.0013131986,
-0.025653182,
0.031163866,
0.023060719,
-0.00490668,
0.021784846,
0.02315573,
-0.001372581,
0.0085307015,
-0.03227686,
-0.17167272,
0.0041296193,
0.01148964,
-0.0029012528,
0.0240787,
-0.01367491,
0.0011358998,
0.02045468,
-0.0001491982,
0.0035561554,
0.046990115,
-0.012283667,
-0.01909737,
-0.025083112,
-0.013457741,
-0.005833045,
-0.033335563,
0.03819474,
0.036620256,
-0.00032384598,
0.0021411586,
0.0009730225,
0.01574481,
-0.016043419,
0.013640977,
-0.019382404,
0.017074976,
0.0069969394,
-0.011801821,
-0.02197487,
-0.019558854,
0.012521196,
0.012365106,
-0.005137423,
-0.010322352,
-0.0156498,
0.0048388145,
0.0025398687,
0.010933142,
0.00055268017,
0.021730553,
0.00037071563,
-0.00033360164,
0.009304369,
-0.016613489,
0.06031891,
0.0024686097,
-0.021350505,
0.018717322,
0.008720725,
0.020468254,
0.024065128,
0.005782146,
0.03070238,
0.0028079376,
0.010817771,
0.011258896,
-0.00532066,
-0.0025822846,
0.0066813645,
0.002721409,
-0.023657935,
0.010899209,
-0.014319633,
-0.00024728515,
-0.0377604,
-0.016070565,
0.005357986,
-0.015934834,
-0.009270436,
-0.03602304,
0.004014248,
0.012487263,
0.0014786209,
0.028313512,
0.03480146,
-0.020875446,
0.01862231,
-0.0012512713,
-0.0044384077,
-0.0291279,
0.015201886,
-0.012120789,
-0.030756673,
-0.017889362,
0.010335925,
-0.0026925663,
0.0069833663,
-0.0003087883,
-0.009046479,
0.011537146,
-0.0204954,
-0.0051442096,
-0.02215132,
0.0072751883,
0.018608738,
-0.003844584,
-0.030729527,
-0.0051679625,
-0.0011096019,
0.01866303,
-0.011102806,
-0.013335583,
-0.015812676,
0.017251426,
-0.014550377,
-0.018079385,
0.0001322318,
0.04918896,
0.0068985345,
-0.004126226,
0.007017299,
0.019884609,
0.021079043,
0.0044112615,
0.0062266653,
-0.015771957,
-0.02459448,
0.0033101428,
-0.017645046,
0.05874443,
0.019287392,
-0.008340677,
0.023807239,
0.0007304031,
0.010159475,
-0.13725132,
-0.009718348,
0.012806231,
-0.020169646,
-0.0012648444,
0.011089233,
-0.013450954,
0.014930423,
-0.008286385,
0.0337699,
-0.034638584,
-0.0233729,
-0.003759752,
0.0037936848,
0.03501863,
-0.006002709,
0.00088479725,
-0.0143739255,
-0.022178466,
0.019776024,
0.0027417687,
-0.013226998,
-0.019586,
-0.022422781,
-0.001353918,
0.0032660302,
-0.035344385,
0.0201425,
0.017455023,
0.028965022,
-0.000007774053,
-0.0078249,
0.020346096,
-0.016382746,
-0.0123515325,
-0.012555129,
-0.023467911,
-0.03336271,
0.023793666,
-0.0007800298,
-0.0069358605,
0.025951792,
0.007818113,
-0.01007125,
0.019382404,
-0.01582625,
-0.01412961,
0.004024428,
0.00122667,
-0.013362729,
-0.027729869,
-0.03615877,
-0.030675234,
-0.0069833663,
0.004173732,
-0.0077570337,
-0.012378679,
0.015011862,
-0.029290777,
-0.0042178445,
0.0033033562,
0.008143867,
-0.017292146,
-0.0031693217,
0.020766862,
-0.025096685,
-0.006701724,
-0.021621969,
0.027186943,
-0.037516084,
-0.008456049,
0.0110553,
-0.017631473,
-0.030756673,
-0.0035697285,
0.016260589,
-0.02141837,
-0.012582275,
0.0070715914,
-0.010939929,
-0.024404455,
-0.0039362027,
0.021309786,
-0.025341,
0.03933488,
0.013030188,
-0.0100441035,
0.0052935136,
0.0079470575,
-0.012066497,
-0.007383773,
0.0362945,
-0.004991512,
0.008211733,
-0.0030997596,
0.0073702,
-0.003008141,
0.00083729136,
0.018269408,
0.03510007,
-0.009168637,
0.00034399357,
-0.054509617,
0.014401072,
-0.001271631,
0.0143739255,
-0.000767305,
-0.018988784,
0.005602302,
-0.008666432,
0.0031693217,
0.020794008,
-0.008143867,
-0.0028656232,
-0.030023724,
0.022843547,
-0.00050008437,
-0.004024428,
0.007634876,
0.009412954,
0.012419398,
0.03026804,
0.0009925339,
-0.028802143,
-0.0025975544,
0.03349844,
0.01814725,
0.015188312,
-0.016152004,
0.037054595,
-0.0027977577,
0.0025008458,
0.0416966,
-0.023277888,
-0.017115695,
-0.0072548287,
-0.006040035,
-0.020617558,
0.012663714,
0.0069833663,
0.026521862,
0.028747851,
-0.020305376,
-0.030593796,
-0.012914816,
-0.0025330822,
-0.026141815,
0.024852369,
-0.03545297,
0.022314196,
-0.00039446857,
-0.002556835,
0.0424024,
-0.00050856755,
0.013783496,
-0.024010835,
-0.023983689,
0.008252452,
-0.0058635846,
-0.019993193,
0.0025076326,
-0.02149981,
0.040800776,
0.010899209,
0.002819814,
-0.009385807,
-0.005982349,
-0.022531366,
-0.009704775,
0.0045232396,
0.003040377,
-0.009046479,
-0.025856778,
0.015066154,
-0.0017594147,
0.010546308,
0.018377993,
0.012555129,
0.011211391,
0.01692567,
-0.013240571,
-0.0006782315,
0.017414303,
0.00078681635,
0.0066915443,
0.01107566,
0.023047145,
-0.0024601265,
-0.01535119,
0.031625353,
0.006369183,
0.011028154,
-0.0034424807,
0.012989469,
0.001412452,
0.011028154,
0.022395635,
0.034991484,
-0.01657277,
-0.016084138,
-0.0035324025,
0.036403086,
-0.026874762,
0.0069833663,
0.00016266527,
-0.02390225,
-0.01310484,
0.030403772,
-0.0395249,
-0.042320963,
0.008245666,
-0.00389209,
0.015310471,
0.011951125,
-0.004489307,
-0.0037292126,
-0.02429587,
-0.00998981,
-0.01369527,
-0.014007452,
-0.0074244924,
0.037298914,
0.02315573,
0.01596198,
-0.012290454,
-0.0035290092,
0.037054595,
0.005768573,
0.012616208,
-0.02538172,
0.04033929,
-0.004038001,
0.009623337,
0.0008966737,
-0.021377651,
-0.013260931,
0.002641667,
-0.021377651,
0.01007125,
0.021567676,
-0.006470981,
0.071068816,
0.0074244924,
0.0015337617,
0.0006871388,
-0.021513384,
0.010485229,
0.01351882,
0.011292829,
0.0062538115,
-0.009860866,
0.014943996,
-0.0127858715,
0.027729869,
-0.044329785,
-0.01639632,
0.016450612,
-0.011143525,
-0.001861213,
-0.0007808781,
-0.004658971,
0.007105524,
-0.013892081,
0.010383431,
-0.0037902915,
-0.008747871,
-0.006135047,
0.004879534,
-0.013966733,
-0.0016559197,
-0.013776709,
0.023128584,
0.0050559845,
-0.02991514,
-0.011245323,
-0.012100429,
0.008523915,
-0.015704092,
-0.023047145,
0.010458083,
-0.011618584,
0.0073362673,
0.012616208,
-0.0015329134,
-0.020726142,
-0.01107566,
-0.028774997,
-0.048483156,
-0.002012214,
-0.0008428054
] |
The SIR genes are determinants of life span in yeast mother cells. Here we show that life span regulation by the Sir proteins is independent of their role in nonhomologous end joining. The short life span of a sir3 or sir4 mutant is due to the simultaneous expression of a and alpha mating-type information, which indirectly causes an increase in rDNA recombination and likely increases the production of extrachromosomal rDNA circles. The short life span of a sir2 mutant also reveals a direct failure to repress recombination generated by the Fob1p-mediated replication block in the rDNA. Sir2p is a | [
-0.01154342,
-0.026980022,
-0.0297842,
-0.046527606,
-0.023563279,
0.009692117,
-0.004158626,
0.025224006,
-0.017777955,
-0.015041838,
-0.011305201,
0.012632421,
0.010890019,
0.030873204,
0.007432438,
-0.005792129,
0.012516716,
-0.009678504,
0.018131882,
0.010502062,
-0.010413581,
-0.007629819,
-0.013319854,
-0.020813549,
0.004655483,
0.0117884455,
0.00072018756,
-0.037216637,
-0.01019578,
-0.00086907455,
0.009515154,
-0.004584017,
-0.022025064,
-0.007650238,
-0.024094166,
-0.0048188334,
0.0074868877,
0.0053905593,
0.009440285,
-0.022732913,
0.01995596,
0.012557553,
-0.004692917,
0.017138166,
-0.00632642,
-0.012360171,
0.0037366378,
-0.011876927,
0.0051319213,
0.014415662,
0.0047677862,
0.012523522,
-0.03699884,
0.0046384674,
-0.030002002,
-0.006088201,
-0.009283741,
0.014647075,
0.0041926573,
-0.00045857189,
0.004886896,
-0.006190295,
-0.039449092,
0.01580414,
-0.008984266,
0.02308684,
0.006425111,
-0.009835049,
0.0018376907,
0.0054824436,
0.036862712,
0.014007286,
-0.005673019,
0.007309925,
-0.0020520878,
-0.0283685,
-0.026789445,
0.019697322,
0.0029352005,
0.009474317,
0.034330785,
-0.0067518116,
-0.0144701125,
0.00577171,
0.016675342,
-0.008759659,
-0.00015537419,
0.01564079,
0.0005993764,
-0.00291308,
0.032533932,
0.042552747,
0.026966408,
0.011618288,
-0.023944428,
0.0022920086,
0.008841334,
-0.000432623,
0.0028824518,
-0.022120351,
-0.012925091,
-0.0072418624,
0.0067279898,
-0.010733475,
-0.034058534,
-0.0063808705,
0.0012702186,
-0.042471074,
0.010855988,
-0.009889498,
-0.011407294,
0.03604596,
-0.0030372944,
-0.02621772,
0.026517196,
-0.010536093,
0.013347079,
-0.0059146415,
-0.024448091,
-0.000050488637,
0.033840735,
0.0019670096,
0.023590503,
-0.015518277,
0.023114065,
0.024788406,
-0.008936621,
-0.008984266,
-0.018063819,
-0.0075005004,
0.016430316,
-0.0013535953,
-0.008208351,
0.017464867,
-0.028341273,
0.0060950075,
-0.016539216,
-0.011836089,
-0.0048426553,
-0.040538095,
0.010059655,
0.026340233,
-0.036345437,
-0.008337671,
0.011107819,
0.0036277375,
-0.009222484,
-0.008623534,
0.0051999837,
-0.00055896427,
0.01418425,
-0.013074828,
0.03495696,
-0.010998919,
0.020269047,
0.030927652,
-0.01613084,
0.004328782,
-0.016974816,
-0.025469031,
-0.0005457771,
0.013204148,
0.020405173,
-0.010393161,
-0.008650758,
0.046037555,
-0.0036175281,
-0.0017202826,
-0.007384794,
-0.0027463266,
-0.007718301,
0.01170677,
-0.009447091,
0.007697882,
0.0014922728,
0.015518277,
-0.0089570405,
-0.0225015,
-0.009304159,
-0.020922448,
-0.019234495,
-0.0023651759,
0.028912999,
0.02325019,
-0.00946751,
0.009590022,
0.004992393,
0.014306762,
0.00078867556,
0.00559815,
-0.0023941025,
-0.004134804,
0.011094207,
-0.012605197,
-0.62639385,
-0.03566481,
0.0027905672,
-0.028559074,
0.0077727507,
0.018785283,
0.014579012,
0.011876927,
-0.009474317,
0.02594547,
-0.01580414,
0.014361212,
0.011230332,
0.0019159627,
-0.022746526,
-0.033895183,
0.0062039075,
-0.0045159548,
0.02405333,
0.02190255,
-0.026911959,
0.0051353243,
0.017968532,
0.027429234,
0.0012727709,
0.021113023,
0.030655403,
-0.032207232,
0.010420387,
0.007697882,
-0.009304159,
0.030219803,
-0.010229811,
-0.0044615045,
0.045955878,
-0.0057104537,
0.015994715,
0.012087921,
0.035909835,
0.04159987,
-0.023821916,
-0.004522761,
0.020187372,
0.0022698883,
-0.01165232,
-0.0038421347,
-0.016062777,
0.021153862,
0.004577211,
-0.016117228,
0.015273252,
0.0032721104,
-0.026313007,
-0.0010030728,
0.0069253715,
0.019506745,
0.026626095,
-0.01822717,
0.02459783,
-0.0037944908,
-0.0068505025,
0.032288905,
-0.012904672,
0.0048188334,
0.0038557472,
0.006867518,
-0.014715138,
0.014783201,
0.02476118,
0.0078680385,
0.008616727,
0.008181127,
-0.0041688355,
0.02001041,
-0.015205189,
0.031009328,
-0.0059997197,
0.002720803,
-0.004808624,
0.011488969,
0.008432958,
0.0006976418,
-0.029811427,
-0.01898947,
0.02853185,
-0.034548584,
-0.018649157,
0.026285782,
-0.021426111,
-0.0017415523,
0.001820675,
-0.0145381745,
0.00047048283,
-0.009998399,
-0.012768547,
0.030328702,
-0.009549185,
-0.009678504,
0.0074052126,
-0.029266926,
-0.0006261761,
0.006323017,
-0.0033452776,
-0.00828322,
0.020691035,
0.01964287,
-0.008589502,
0.010556512,
0.014660687,
-0.01775073,
0.01726068,
0.011482163,
0.0064591425,
0.017247068,
-0.0057683066,
-0.025278457,
0.04995796,
0.019629259,
-0.006976418,
-0.007024062,
0.029566402,
-0.006605477,
-0.0003792364,
-0.021181086,
0.0027922688,
0.039803017,
0.0024604637,
0.0017372983,
-0.008194739,
-0.011223526,
-0.0058125476,
-0.0033810104,
0.010849182,
-0.03171718,
0.017723506,
0.00005290805,
0.01580414,
0.008058614,
0.033813506,
-0.019874284,
-0.042334948,
0.0029556192,
0.0058465786,
-0.0014225087,
-0.0128774475,
-0.028940225,
-0.018703608,
-0.01580414,
0.02146695,
-0.018268006,
0.0144701125,
0.023876365,
-0.007976939,
0.004971974,
-0.008330864,
-0.016375866,
-0.014075349,
-0.018431356,
-0.03699884,
-0.0031189695,
0.022093125,
0.013415142,
-0.0022920086,
-0.02470673,
-0.009943948,
-0.015341314,
0.013074828,
-0.007085318,
-0.026830284,
-0.009365416,
0.0012778756,
-0.011747608,
-0.02643552,
-0.0030168756,
-0.008752853,
0.037461665,
-0.00031606577,
0.017247068,
-0.013592104,
-0.014647075,
-0.013721423,
-0.032615606,
-0.014497337,
-0.010481643,
0.036318213,
0.014647075,
0.034385234,
0.003406534,
0.017002042,
0.013701005,
0.003723025,
0.017682668,
-0.0069253715,
0.03166273,
0.018635545,
-0.012006246,
0.018689994,
-0.005700244,
-0.0043730233,
0.012938703,
0.008092646,
-0.019602034,
0.025469031,
-0.039721344,
0.010828762,
-0.013333467,
0.024802018,
-0.010910437,
0.010781119,
0.003129179,
-0.0013110562,
0.023454377,
-0.023930816,
-0.009869079,
0.016389478,
0.0025438403,
-0.011005725,
0.011727189,
0.0065408177,
0.007976939,
-0.036726587,
-0.009229291,
0.0032584977,
-0.017614605,
-0.0019329783,
0.0057683066,
0.0030100693,
0.0029300957,
-0.0011596169,
-0.015940266,
-0.021153862,
-0.0030253832,
0.008997878,
0.024502542,
-0.0059418664,
0.022378989,
0.03550146,
-0.009964367,
0.04094647,
-0.0072214436,
-0.0036073187,
0.015300476,
0.0061018136,
-0.010059655,
0.008888978,
-0.004233495,
0.030737078,
0.0067654243,
-0.016389478,
0.010590543,
-0.0111963,
0.033405133,
-0.005591344,
0.008589502,
0.0021473756,
0.00019419115,
-0.00459763,
-0.0016122332,
0.013476398,
0.0031547023,
0.0095355725,
0.010481643,
0.021861713,
-0.024243904,
0.0066939583,
0.0012030067,
0.010413581,
-0.0110601755,
0.008167514,
-0.015055451,
-0.015831364,
0.024570605,
0.014456499,
-0.01747848,
0.010277455,
0.002145674,
0.00029734857,
0.03144493,
0.0097533725,
-0.006819874,
-0.007255475,
-0.030410377,
0.038169514,
0.011325619,
-0.008895784,
-0.0290219,
-0.014374824,
-0.010760699,
0.0019465908,
0.010719862,
0.01645754,
0.010073267,
0.00041156614,
0.015463826,
-0.0034984185,
-0.019125596,
0.021820875,
-0.031962205,
0.022787364,
0.0122172395,
0.010726668,
0.020187372,
0.013299435,
-0.015831364,
0.06762701,
-0.0073984065,
0.005591344,
0.006261761,
-0.013360691,
-0.024107778,
-0.008276414,
-0.0043560076,
-0.006738199,
-0.00935861,
0.007915682,
0.002940305,
-0.009208872,
-0.02583657,
0.0068743243,
-0.015599952,
-0.021317212,
-0.015790528,
-0.004230092,
-0.015831364,
0.023767466,
0.04257997,
-0.015531889,
0.013095248,
-0.00074486027,
0.013564879,
0.009208872,
-0.017315129,
0.012414621,
-0.023563279,
-0.00795652,
-0.016035553,
0.013823518,
-0.00008821553,
0.0033656964,
0.008548665,
0.024938142,
-0.03904072,
-0.023386315,
0.008412539,
0.02028266,
-0.015109901,
0.019901508,
0.050094087,
0.024461705,
-0.012121952,
0.012646034,
0.04105537,
-0.006918565,
-0.032724507,
0.009202066,
0.015014613,
0.0023005165,
0.03275173,
0.008310446,
-0.025319293,
0.013088441,
0.01931617,
-0.018866958,
0.007731913,
0.0046350644,
0.0034303558,
0.023331866,
0.010910437,
0.009528766,
-0.017219841,
-0.013353885,
0.00689134,
-0.0045397766,
-0.028749648,
0.032452255,
-0.017995756,
-0.019547584,
-0.019615646,
-0.005363334,
-0.02703447,
-0.008936621,
-0.012176402,
-0.00431517,
-0.013224566,
-0.00570705,
-0.009379028,
0.040919244,
0.0011323917,
0.0014114485,
-0.0074188253,
-0.00043389917,
-0.019915123,
-0.016103616,
-0.013721423,
0.012666453,
-0.0290219,
-0.01607639,
0.01372823,
0.00828322,
0.018417744,
-0.014225087,
-0.023536053,
-0.010910437,
0.011407294,
-0.017410418,
-0.0035869,
-0.012625615,
-0.03226168,
-0.0033622934,
0.008038195,
0.021004124,
-0.035828162,
-0.029947551,
-0.0043832324,
0.003981663,
0.012169596,
0.013864355,
-0.0074052126,
-0.009658085,
0.011189494,
0.020745486,
0.019806221,
-0.0055437,
0.0035052248,
-0.020799935,
-0.02638107,
-0.0438051,
-0.025482643,
-0.0011740802,
-0.010297874,
0.0035834967,
0.0044853264,
-0.017451255,
-0.00050408876,
0.010318292,
0.007840813,
0.0049005086,
0.0032448852,
0.020813549,
0.049903512,
-0.005795532,
0.023263803,
-0.007078512,
-0.014551788,
-0.006523802,
-0.03139048,
0.021085799,
0.005907835,
-0.04159987,
0.021072187,
-0.0005585388,
-0.024556993,
-0.016144453,
0.016498378,
-0.013319854,
0.03155383,
-0.0073711816,
-0.027116146,
-0.021943389,
-0.0041722385,
-0.0048766863,
0.003539256,
0.0016819974,
0.005359931,
-0.04407735,
-0.010223005,
0.0019278736,
-0.022555951,
0.0020997317,
-0.03247948,
0.0030372944,
0.02767426,
0.020309884,
-0.0006172429,
0.0037128157,
0.014592625,
-0.010992113,
-0.013476398,
-0.014102574,
-0.04241662,
0.015831364,
-0.02541458,
0.03716219,
0.021957,
0.02120831,
-0.0022307523,
0.016743403,
0.025931858,
0.025210394,
0.0012106638,
-0.0071669933,
0.0044546984,
-0.012298915,
0.020827161,
0.026258558,
-0.009617248,
0.01048845,
-0.028259598,
0.02395804,
0.028177923,
-0.019057533,
-0.011366457,
0.020922448,
-0.04840613,
-0.01984706,
0.005700244,
-0.019370621,
-0.007309925,
-0.0069832243,
0.0039952756,
-0.0052067903,
0.012394203,
-0.0076910756,
-0.0012446952,
0.00873924,
-0.022841815,
0.051618688,
-0.024897305,
0.02416223,
-0.02438003,
0.010372743,
-0.0051353243,
0.00080016116,
0.0033384713,
-0.00039008388,
0.008800496,
-0.009453897,
-0.017546542,
0.017709892,
0.0068573086,
-0.0077795573,
-0.037352763,
0.016893141,
-0.0038897786,
0.010883212,
-0.021235537,
-0.03231613,
-0.036644913,
-0.0016003223,
-0.005519878,
-0.015668014,
0.034630258,
-0.015341314,
-0.021643912,
0.028096247,
0.0061460542,
0.019915123,
-0.0027514312,
0.033105657,
0.011482163,
0.0071125436,
-0.029321374,
-0.0036719781,
0.02438003,
-0.00012963802,
0.026517196,
0.03226168,
-0.010896825,
-0.02071826,
0.0037536533,
-0.0014633463,
-0.0067790365,
-0.046636503,
0.0020367738,
-0.027578972,
0.028831324,
-0.006319614,
0.010093686,
-0.015109901,
-0.005952076,
0.0025914842,
0.009562798,
-0.0050876806,
0.0035664812,
0.005673019,
-0.015041838,
-0.006370661,
0.0024910918,
0.0035494654,
-0.025264842,
-0.012332946,
-0.032452255,
-0.005169356,
-0.010039236,
-0.011107819,
0.03264283,
0.000618519,
0.0034984185,
-0.016743403,
0.019547584,
-0.01693398,
-0.020827161,
-0.0014948252,
0.03825119,
0.008031389,
-0.017954918,
-0.0073235375,
0.0027259078,
-0.0012455459,
0.0038795692,
0.0089570405,
0.015844977,
-0.02659887,
-0.0050332304,
0.039258517,
0.0155591145,
-0.009317772,
-0.014293149,
-0.022120351,
-0.012979541,
-0.015627177,
-0.022419825,
-0.0060950075,
-0.031172678,
-0.005281659,
-0.006275373,
0.021535013,
0.030546503,
0.0059282538,
-0.003457581,
-0.019983184,
0.03354126,
-0.025373744,
0.010998919,
-0.010461224,
-0.011271169,
-0.027851222,
0.030110901,
-0.009079553,
-0.026612483,
0.0055505065,
0.004413861,
-0.019588422,
-0.0071329623,
0.0062549543,
0.026952796,
0.021766424,
-0.006397886,
0.013490011,
0.0029539175,
0.010998919,
-0.012019858,
-0.010971694,
0.0122921085,
-0.01931617,
0.004584017,
0.008487408,
-0.014061737,
0.000006999017,
-0.002212035,
0.003974857,
0.0151235135,
0.015722465,
-0.019411458,
-0.0014658986,
-0.006806262,
0.019928735,
-0.0035222403,
-0.0015084378,
-0.031199904,
-0.025809344,
0.02550987,
-0.0027174,
-0.007670657,
-0.012121952,
-0.006789246,
0.00056321814,
0.010610962,
-0.005067262,
0.0067620208,
0.007936101,
-0.01580414,
-0.023263803,
-0.006190295,
-0.0065408177,
0.030301478,
0.010331905,
-0.008929815,
-0.018758057,
-0.0055471035,
-0.038550667,
-0.019561196,
-0.0014131501,
0.013156503,
-0.00085758895,
0.019833447,
-0.0051625497,
0.015953878,
-0.009617248,
0.026775833,
-0.012897866,
-0.025319293,
0.01849942,
0.01640309,
-0.00096648914,
0.015014613,
-0.03144493,
-0.008895784,
0.030274251,
0.0011306902,
-0.015450214,
0.02222925,
-0.013796292,
0.013918805,
-0.008194739,
0.010964887,
0.012931897,
-0.0006972164,
0.013898387,
-0.0214125,
-0.015926652,
-0.0011672738,
-0.003542659,
-0.014769588,
0.006442127,
-0.015232414,
0.023549665,
-0.00025885063,
0.0055437,
-0.037053287,
-0.006340033,
-0.010862794,
0.022964327,
0.013680586,
0.020269047,
0.016974816,
0.010781119,
-0.022555951,
-0.0071329623,
-0.007092125,
0.000667439,
0.004863074,
0.003033891,
0.0055437,
-0.02405333,
0.0032857228,
-0.023644954,
-0.013367498,
0.000034669396,
-0.002810986,
-0.024311967,
-0.025319293,
0.011305201,
-0.007514113,
0.016348641,
-0.022256475,
0.0025914842,
-0.022909876,
-0.023495216,
0.01192457,
-0.025360132,
0.0040088883,
0.011890539,
-0.01125075,
-0.009590022,
-0.011291588,
-0.0065884613,
-0.0059929136,
-0.007861232,
0.022256475,
0.19471353,
-0.0104067745,
0.017737119,
0.023753854,
0.008936621,
-0.012918285,
0.019220883,
-0.015436602,
-0.0015271549,
0.013932418,
-0.002654442,
0.012843416,
0.0048766863,
0.0014386736,
0.03144493,
-0.0032874243,
-0.014987389,
0.001327221,
-0.03522921,
0.008432958,
0.009127197,
-0.016498378,
-0.007201025,
-0.016688954,
0.030927652,
-0.000786974,
-0.056246947,
-0.0138847735,
0.010794731,
0.0055607157,
-0.028885774,
-0.01327221,
-0.020854386,
-0.0065135923,
-0.0071329623,
-0.00024949203,
0.00344567,
0.0015535292,
-0.0006244745,
0.0016743403,
-0.00048962544,
0.020622972,
0.009692117,
-0.017029267,
-0.003038996,
-0.0052408213,
-0.006741602,
-0.0095355725,
-0.015708853,
0.011325619,
-0.05140089,
0.009276935,
0.010379549,
0.035991512,
0.016144453,
-0.006452336,
0.024448091,
0.004505745,
-0.003644753,
-0.0020180566,
-0.023781078,
0.0073711816,
-0.038223967,
-0.031036554,
-0.024665892,
0.053388316,
-0.02896745,
-0.001710924,
0.008943428,
-0.012598391,
-0.0063298233,
-0.014701526,
-0.0071669933,
0.0015203487,
-0.014415662,
-0.0059418664,
0.02745646,
0.006346839,
0.024461705,
0.01283661,
0.01769628,
-0.009943948,
-0.018853344,
0.02459783,
-0.0054654283,
-0.037379988,
0.024393642,
0.004893702,
-0.024693117,
-0.009106779,
0.01909837,
-0.01709733,
0.011359651,
-0.019506745,
0.001444629,
-0.02659887,
-0.01035913,
0.018948633,
-0.007548144,
-0.027932897,
-0.024461705,
0.05012131,
0.0045704045,
0.00019621177,
-0.013809905,
-0.0035562718,
0.011182688,
0.021194698,
-0.007929295,
-0.031227129,
0.0066633304,
-0.028096247,
0.021671137,
-0.0024587621,
-0.0074800816,
0.0050060055,
0.027796773,
-0.015885815,
0.04298835,
-0.011073788,
-0.0093926415,
-0.027020859,
-0.012373784,
0.031526603,
-0.026639707,
-0.0058329664,
-0.019248107,
0.0039680507,
-0.015055451,
-0.029403051,
0.012598391,
0.0015143933,
0.0014471813,
0.0008516335,
0.017764343,
-0.0138847735,
0.0055743284,
-0.012782159,
-0.021276373,
0.0074868877,
-0.009208872,
0.0053020776,
0.0006091604,
0.017315129,
-0.03830564,
-0.022909876,
0.017355967,
0.011312007,
-0.0037774753,
0.026326621,
0.0073711816,
-0.016688954,
0.007051287,
-0.0014990792,
-0.0004273056,
-0.024175841,
-0.025550706,
-0.045220803,
-0.016852304,
0.013632942,
-0.026040757,
0.008031389,
0.010148136,
-0.00038263953,
-0.0036515594,
0.019928735,
-0.1727157,
-0.001742403,
0.007180606,
-0.024448091,
0.021358049,
0.0036073187,
0.025346518,
0.019915123,
0.0038829723,
-0.000117088974,
0.00828322,
0.02432558,
-0.03275173,
-0.04968571,
-0.012244465,
0.029729752,
-0.014483725,
0.02567322,
0.029484726,
-0.008324058,
0.011992633,
-0.019969571,
0.013279016,
-0.012135564,
0.00040093134,
0.00040114406,
-0.00023417795,
-0.006275373,
-0.002509809,
-0.016539216,
-0.03533811,
0.020323498,
0.028477399,
-0.03424911,
0.015627177,
-0.0038625535,
-0.02687112,
0.015341314,
0.0029198863,
0.0023277416,
0.03452136,
0.0143203745,
0.019738158,
0.010638187,
-0.008324058,
0.030247027,
0.0021201505,
0.015531889,
0.0022460665,
-0.004971974,
0.010610962,
-0.0067552147,
0.0016283981,
0.021181086,
0.009617248,
-0.015981102,
-0.017110942,
0.012264883,
0.00023481603,
0.014769588,
-0.027361171,
-0.0027837611,
0.054531768,
-0.0075821755,
0.013864355,
-0.025428193,
-0.012264883,
0.024039716,
-0.017192617,
0.021031348,
-0.009072747,
0.02190255,
0.004029307,
-0.0053259,
0.00811987,
0.018608319,
-0.011570645,
-0.0034439685,
-0.012339752,
0.0025710654,
-0.02179365,
0.032370582,
0.005798935,
-0.022977939,
-0.00014282514,
0.0043730233,
0.014197862,
0.019602034,
-0.0011893943,
-0.020691035,
0.032860633,
-0.017805181,
0.009549185,
-0.01121672,
0.026993634,
-0.0014710033,
-0.016171677,
-0.009365416,
0.0039136005,
-0.0028518236,
-0.010018817,
-0.014061737,
-0.02454338,
-0.0039374223,
0.03539256,
-0.011441326,
-0.010570125,
-0.0012404412,
0.038931817,
-0.009943948,
0.018268006,
-0.0050876806,
-0.0057104537,
0.022719301,
-0.002681667,
0.025877407,
-0.01602194,
-0.009766986,
0.022651238,
-0.01915282,
0.072309725,
0.0029420066,
0.013694199,
-0.014592625,
-0.001170677,
-0.01720623,
-0.13383833,
-0.018036593,
-0.006190295,
0.033078432,
-0.018444968,
-0.00080569123,
0.009161228,
0.018921407,
-0.009542379,
0.019874284,
-0.011080594,
-0.019071145,
-0.00277185,
0.0037638627,
0.007187412,
-0.01070625,
0.01238059,
-0.014592625,
-0.014429275,
0.0290219,
0.0054960563,
0.0058908197,
0.009344997,
0.009385834,
0.005359931,
-0.0075073065,
-0.022447051,
0.012121952,
-0.0033810104,
0.025714057,
-0.010760699,
-0.021221925,
0.0022852023,
0.016198903,
-0.021970613,
-0.011352845,
-0.0018530048,
-0.031009328,
0.024938142,
-0.018581094,
0.014306762,
0.009106779,
0.023318252,
0.00026331726,
0.013592104,
-0.004573808,
0.016335027,
0.037679464,
0.010665412,
-0.020813549,
-0.04644593,
-0.0063842735,
-0.043914,
-0.016825078,
0.025564319,
-0.022964327,
0.030791529,
0.011958602,
0.0004241152,
0.00946751,
0.012319334,
0.0056628096,
-0.021507787,
-0.0056832284,
0.0044308766,
-0.03204388,
0.00023077481,
-0.04968571,
0.034140207,
-0.021916162,
-0.010331905,
0.002353265,
-0.008269608,
0.005462025,
-0.014592625,
-0.0058908197,
-0.024066942,
-0.033323456,
-0.0038285223,
-0.009433479,
0.008868559,
-0.016852304,
0.02314129,
-0.03441246,
0.037516113,
-0.00015016315,
0.0073779877,
-0.0007384794,
0.0064897705,
-0.0029334987,
0.009440285,
0.034494136,
0.01289106,
-0.0091748405,
-0.023454377,
0.010318292,
-0.007650238,
-0.004145013,
0.02610882,
0.0013799695,
-0.03841454,
-0.010835568,
-0.05551187,
0.023604115,
0.012047083,
-0.005822757,
0.011808864,
-0.018118268,
0.026367458,
0.0073439563,
-0.014279537,
0.020990511,
-0.014687913,
0.0048460583,
-0.013551267,
-0.009140809,
-0.0073235375,
-0.01361933,
0.025795732,
0.004063338,
0.03985747,
0.027687872,
0.019193659,
-0.013993674,
0.014851263,
0.011958602,
0.0035800936,
0.011046562,
-0.011516195,
0.009862273,
-0.004601033,
-0.008290026,
-0.006323017,
-0.035256434,
-0.0052033872,
0.0014344197,
-0.015831364,
-0.013510429,
0.0148921,
0.035746485,
0.023277415,
0.0051897746,
-0.012972735,
-0.03188053,
0.0043083634,
0.0064012893,
0.004294751,
0.015518277,
-0.039966367,
0.018785283,
0.020731874,
-0.0032278695,
0.018077431,
0.0021235535,
-0.02412139,
-0.012788965,
-0.0055539096,
-0.008616727,
-0.00014814254,
-0.0013578492,
-0.011917764,
-0.031227129,
0.012714096,
-0.00041028997,
0.021276373,
0.017873242,
0.0053803497,
-0.026122432,
-0.012577971,
0.0061222324,
-0.011577451,
-0.04023862,
-0.022773752,
0.008364895,
0.006615686,
0.011243944,
0.010420387,
0.016198903,
-0.016375866,
-0.010161749,
-0.018063819,
0.016961204,
0.007752332,
-0.0077727507,
-0.026244946,
0.012196821,
0.020350723,
0.006911759,
0.010148136,
0.019329783,
0.018376907,
0.011182688,
0.000008926571,
0.014211474,
0.0223926,
-0.011972214,
0.010216199,
0.014660687,
-0.028123474,
0.00090438203,
-0.000747838,
0.004971974,
-0.0050910837,
-0.009596829,
-0.0021269568,
-0.013244986,
-0.022052288,
0.045248028,
-0.02395804,
-0.032180004,
-0.014647075,
-0.011727189,
0.003723025,
0.0043015573,
-0.0032857228,
0.015885815,
0.0037128157,
0.010352324,
-0.0014233595,
-0.008290026,
-0.0046452736,
0.0051353243,
0.012087921,
-0.006353645,
-0.0025778715,
-0.013279016,
0.03291508,
0.012258077,
0.030737078,
-0.026966408,
0.0007244415,
-0.013939224,
0.037298314,
-0.017655443,
-0.02497898,
-0.019343395,
0.00863034,
-0.0023158304,
0.017886857,
0.032778956,
-0.025196781,
0.09479761,
0.020813549,
-0.023903592,
0.012959123,
-0.024448091,
0.023672178,
0.00026289184,
-0.00055471034,
-0.03533811,
-0.052408215,
0.02578212,
-0.04211715,
0.035365336,
-0.01238059,
-0.0063366294,
0.022215638,
-0.0038387317,
0.023767466,
-0.004604436,
-0.031336028,
0.0040190974,
-0.01564079,
0.0012064099,
0.02071826,
-0.0023073228,
0.007881651,
0.05232654,
-0.0011910958,
0.02962085,
-0.03637266,
0.004675902,
0.01048845,
-0.023127677,
-0.0008933218,
0.018594706,
-0.0031138647,
0.0016539216,
-0.0024570604,
0.03160828,
0.010944469,
0.0010566721,
-0.027061697,
-0.0026527406,
-0.011747608,
0.017301517,
0.01952036,
-0.00076570443,
0.0022409617,
-0.016811466
] |
Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P < 5.0 × 10(-8)), including seven previously identified loci (FTO, SEC16B, MC4R, GIP | [
-0.024125956,
-0.0016586595,
0.023395658,
-0.04293116,
-0.024986666,
0.0036286742,
-0.01935293,
0.003599332,
-0.0152580375,
-0.01714899,
-0.0029195668,
-0.023330452,
0.015362366,
-0.0027777452,
-0.008809234,
0.01640565,
0.022652317,
-0.008965727,
0.0018078166,
0.0025022528,
-0.049164787,
0.0044730827,
-0.005822832,
-0.011110981,
-0.009761231,
0.021556867,
0.025090994,
-0.015844885,
-0.015636228,
-0.025260529,
0.01493201,
-0.003736263,
-0.037323505,
0.005487025,
-0.019339887,
-0.000006342233,
-0.005509847,
-0.016327403,
0.000045363522,
-0.036462795,
-0.0012030376,
0.019261641,
0.00043320764,
0.016001377,
0.0007893915,
0.00333036,
0.0246476,
-0.013823521,
-0.00047029313,
0.007426882,
-0.023930341,
0.035315182,
-0.030933388,
0.0009136891,
-0.025234446,
0.008170223,
0.008026771,
-0.0018779123,
-0.0015853036,
-0.028012192,
0.0023115275,
-0.0077724704,
-0.03367201,
0.007068253,
-0.020435337,
-0.016718635,
-0.008913563,
0.011880403,
0.009591698,
0.008561454,
0.03221141,
0.021491664,
-0.00060844683,
0.0071204174,
0.03748,
-0.025638718,
-0.0019333367,
0.020317968,
-0.013797439,
0.007361677,
0.027203646,
-0.022600152,
0.014279958,
0.01875304,
0.012134704,
-0.019783285,
-0.00049026223,
-0.00065449806,
0.004489384,
0.0029065257,
-0.018022742,
0.002021364,
0.0060217083,
0.0016741457,
-0.016470855,
0.0041144537,
0.0018811725,
0.017957537,
-0.00009913241,
-0.0067878705,
-0.0047045616,
0.01023723,
-0.023121795,
-0.006709624,
-0.030985553,
0.009311315,
-0.0049653826,
-0.016314363,
-0.0020816787,
-0.00044787882,
-0.011437007,
0.023486944,
-0.0028282793,
-0.017840166,
-0.0060217083,
-0.01837485,
0.004786068,
-0.0032961273,
-0.0144234095,
0.0016676253,
0.03046391,
0.031246373,
0.03288955,
0.006194502,
-0.0032847163,
-0.00034008632,
-0.025130117,
-0.0033613325,
-0.018322686,
-0.016066583,
0.018792164,
0.0020197337,
0.0031380043,
0.0128324,
-0.041496646,
0.001874652,
0.0022137195,
-0.01146961,
-0.026864579,
-0.022534948,
0.014097383,
0.027438385,
-0.032498315,
0.0039253584,
0.0035699895,
0.035236936,
0.016692553,
0.008548413,
0.019770242,
-0.023721684,
-0.010921885,
0.009735149,
0.019652873,
0.026421182,
0.02353911,
0.005473984,
0.018453097,
0.048669226,
-0.033828504,
-0.032967795,
-0.011326158,
-0.010543695,
-0.0013652357,
0.017422853,
-0.00042750215,
0.0120042935,
-0.0013497494,
-0.043113735,
0.0021028705,
-0.011652185,
-0.013249714,
0.028299095,
-0.039644815,
0.021074349,
-0.008548413,
0.00912222,
0.00010881132,
0.00017931453,
-0.0018762822,
-0.02353911,
-0.02073528,
0.034715295,
0.042722505,
0.0010416545,
-0.009885121,
0.011691308,
0.024451982,
-0.017553262,
0.015584064,
-0.05732849,
0.0180097,
0.0029211969,
-0.009070056,
-0.010387202,
-0.6460018,
-0.008639701,
-0.0027663342,
-0.013347522,
-0.006119516,
0.030829059,
0.018609589,
0.025338775,
-0.002983142,
0.022508865,
-0.017435893,
0.0134322895,
0.019939777,
-0.032654807,
-0.017618468,
-0.037062686,
-0.000079570826,
-0.013367084,
0.03635847,
-0.017240278,
-0.03974914,
0.020891774,
0.009637342,
0.024712805,
0.011854321,
0.009591698,
0.015323242,
-0.017070744,
-0.008535372,
0.029055476,
-0.008111537,
0.02466064,
0.012343361,
0.031246373,
0.046660904,
-0.026056033,
-0.02158295,
0.037323505,
0.0047534653,
0.019457258,
-0.01504938,
-0.031481113,
0.037662573,
0.0034460993,
0.000684248,
0.03343727,
0.0059793247,
0.021556867,
0.026421182,
-0.027021071,
0.016353486,
0.0071725817,
-0.012486813,
-0.017553262,
0.007042171,
0.0031738672,
0.03661929,
-0.012682429,
0.00937652,
0.007537731,
-0.008007209,
0.0031249635,
0.0006769124,
-0.028142601,
-0.0030043337,
0.019678956,
-0.013230152,
0.022900097,
0.008952686,
-0.0086723035,
0.004303549,
0.0399578,
-0.0092265485,
0.021856813,
0.029185887,
0.026316853,
0.01739677,
0.030620404,
-0.026864579,
0.00407533,
-0.009448246,
0.0024582394,
0.00012959552,
-0.0061716805,
0.01184128,
0.0051773,
-0.0038634134,
0.011319638,
-0.011815198,
-0.006448803,
0.020317968,
-0.014540779,
-0.0019952818,
-0.009643862,
-0.014566861,
0.005998886,
-0.016679512,
0.003912317,
0.012721552,
-0.018309645,
-0.038079888,
-0.008600578,
-0.007263869,
-0.013575741,
0.014788559,
0.008326715,
-0.016588226,
0.020617912,
0.025312692,
-0.025873458,
0.008098497,
-0.009076576,
-0.0021175416,
-0.0012062978,
0.0057185036,
-0.022756645,
-0.0043133297,
-0.017292442,
-0.024569353,
-0.006709624,
0.020670077,
0.014019136,
0.012147745,
-0.01602746,
0.008359318,
0.032759137,
-0.012317278,
-0.010771913,
0.00014752697,
-0.018322686,
-0.011078378,
0.006650939,
0.0044600414,
-0.00616842,
-0.0028184985,
-0.008809234,
0.0078376755,
-0.003785167,
0.003157566,
-0.044704746,
-0.017579345,
-0.029029394,
0.009891642,
-0.018061865,
-0.012147745,
-0.022521906,
0.0049979854,
-0.008131099,
0.021791607,
-0.013927849,
0.015505818,
-0.016444774,
-0.0144234095,
0.00021375107,
0.005757627,
-0.0040133856,
-0.0015037969,
-0.020187557,
-0.004401357,
0.0028266492,
0.007961566,
-0.009845998,
-0.0008158812,
-0.012467251,
0.0062792692,
-0.029785775,
-0.019574627,
0.022039387,
-0.031298537,
-0.017605428,
0.026786331,
-0.028168684,
-0.00580001,
0.0039905636,
-0.023695601,
0.013706151,
-0.004759986,
-0.017331565,
-0.0020148433,
-0.029290214,
0.007824634,
-0.012943249,
-0.04180963,
-0.00046214246,
0.055450577,
0.0068400344,
0.021035226,
0.0009210247,
0.017240278,
0.0029440187,
-0.019939777,
0.009148302,
-0.014136506,
0.019052984,
0.022221962,
0.012017335,
-0.013008455,
-0.00815066,
-0.004535028,
0.0022707742,
0.019770242,
-0.010191587,
-0.0073095127,
-0.030307418,
0.027803535,
-0.023526067,
0.01751414,
-0.014084342,
-0.016457815,
0.010439366,
0.014853764,
0.012845442,
-0.008581016,
0.0022772946,
0.0003225624,
-0.009578656,
0.0065042274,
-0.008698385,
0.015571022,
-0.006455323,
0.0152971605,
0.004238344,
0.02356519,
-0.0048382324,
-0.026395101,
0.00888096,
0.0053826966,
0.026355976,
0.010648023,
-0.0153362835,
-0.0096243005,
0.006253187,
0.0066020354,
0.010739311,
-0.0057869693,
-0.019822408,
0.009030933,
-0.020696158,
0.019261641,
0.015923131,
-0.0049001775,
-0.005698942,
0.012962811,
-0.017070744,
0.0019545285,
-0.013001935,
0.015584064,
0.0037949476,
-0.016627349,
0.0212178,
-0.0020735282,
-0.013106262,
0.0019594189,
0.007909401,
0.033254698,
-0.017657591,
0.016418692,
0.016079623,
0.02403467,
0.027177563,
0.02146558,
-0.00013102188,
-0.019274684,
0.0003476257,
0.008724468,
0.0006561282,
0.013927849,
-0.0050957934,
0.0025201843,
-0.0035276061,
-0.04525247,
-0.0063933786,
0.01060238,
-0.03701052,
0.012486813,
0.005379436,
0.010752352,
0.0120434165,
0.017305484,
0.012604182,
-0.013308399,
-0.014332122,
0.020031065,
0.012532456,
-0.0062368857,
0.00088271656,
-0.002886964,
-0.00788984,
-0.021478621,
0.008483208,
0.007746388,
0.020422297,
-0.01714899,
-0.01591009,
-0.0148016,
0.007844196,
0.01630132,
-0.020604871,
0.02540398,
0.002575609,
0.0049393005,
0.0026424443,
-0.02614732,
-0.022808809,
0.027907863,
-0.009552575,
0.0011940718,
-0.0083527975,
0.015870966,
-0.004332891,
0.0055326684,
-0.03638455,
-0.012891085,
0.022404537,
-0.010335038,
0.013745274,
-0.0097025465,
0.022521906,
0.02097002,
-0.0060249683,
-0.003971002,
-0.04895613,
-0.023904258,
0.016822964,
0.042096533,
0.011260953,
-0.016575184,
0.0032765656,
0.006709624,
0.024099873,
-0.013640946,
-0.013138865,
0.017722797,
0.004857794,
-0.005193601,
-0.0008138435,
0.006621597,
-0.0058195717,
0.007948524,
-0.0065661725,
0.020578789,
-0.04217478,
-0.026668962,
-0.0045056855,
-0.021165635,
-0.0046686986,
0.028351258,
0.051225275,
0.021361252,
-0.020813528,
0.0050599305,
0.045461126,
-0.0101785455,
-0.028325176,
-0.0154145295,
-0.006879158,
-0.0055261482,
0.03946224,
-0.0007192958,
-0.00998945,
0.026708085,
-0.026434224,
-0.0051773,
-0.009559095,
0.031376783,
0.0020164736,
0.017735839,
0.036228057,
0.0064781453,
-0.003974262,
0.009774272,
0.0367497,
0.015453653,
-0.0027581837,
0.0071204174,
-0.0077072647,
0.013823521,
-0.01812707,
0.010315476,
-0.012252074,
-0.012375964,
-0.010824078,
0.0046458766,
-0.03635847,
-0.002639184,
-0.014214752,
0.023408698,
0.0001977554,
-0.018674795,
-0.012219471,
-0.017527182,
-0.032706972,
-0.0296032,
-0.0064096795,
-0.003563469,
-0.019066026,
-0.012017335,
-0.01640565,
0.015010257,
0.013380125,
0.010289394,
-0.010419805,
0.019431176,
0.02762096,
-0.019339887,
0.010165504,
0.0028804436,
-0.03242007,
0.011124022,
0.004782808,
0.019131232,
-0.00086967554,
-0.0271254,
-0.0028592518,
-0.003935139,
-0.0058749965,
0.013393166,
-0.004799109,
-0.0007364122,
0.010335038,
0.017227236,
-0.0034330583,
0.0039547007,
-0.018335726,
0.010511092,
-0.012252074,
-0.01049153,
-0.018922575,
0.015571022,
-0.003664537,
0.0025707185,
-0.020852651,
-0.0041992203,
-0.006204283,
0.0057511064,
-0.016783841,
0.007537731,
-0.0005505771,
0.019561587,
0.03565425,
0.023134835,
0.024152039,
0.0076290187,
-0.01824444,
-0.010119861,
-0.013784397,
0.0044078776,
-0.008730988,
-0.015649268,
0.007922443,
-0.013008455,
0.011691308,
-0.020200597,
0.0016016049,
-0.010713229,
0.022274125,
-0.0001503797,
-0.010947968,
-0.009350439,
0.006484666,
-0.00813762,
0.017188113,
-0.024152039,
-0.0039873035,
-0.007126938,
0.012147745,
0.011691308,
-0.02244366,
0.016457815,
-0.026916742,
0.0005709538,
0.0026799373,
-0.023604315,
0.012975852,
0.011821719,
0.0034689212,
-0.010980571,
-0.025469186,
0.0005289779,
-0.015636228,
-0.014579902,
-0.0018338987,
0.04006213,
0.008600578,
0.0076159774,
0.025951704,
0.04572195,
0.023747766,
0.013367084,
-0.003912317,
-0.020344049,
0.0038145094,
-0.01961375,
-0.0032162508,
0.020943938,
0.012154265,
-0.006742227,
0.012010814,
-0.013667028,
0.031768017,
-0.012975852,
-0.017814085,
-0.007237787,
-0.03784515,
-0.017931454,
-0.007792032,
-0.0017784742,
0.033489436,
-0.04449609,
-0.007955045,
0.022300208,
0.020539666,
0.007042171,
-0.001540475,
0.030307418,
-0.036332387,
0.05179908,
-0.0047045616,
-0.011450049,
-0.011815198,
-0.036410633,
-0.005412039,
0.014266917,
0.024321573,
-0.019287724,
0.023721684,
0.004205741,
-0.015466694,
0.0032781959,
0.00518382,
-0.04353105,
0.000011041599,
-0.026408141,
-0.009272192,
0.017461976,
-0.013836562,
-0.011189227,
-0.018961698,
0.0010701817,
0.011378323,
-0.018596549,
0.026342936,
0.0031412647,
-0.009845998,
0.0058815167,
0.02552135,
0.01973112,
-0.011632623,
0.046321835,
-0.004209001,
0.013099742,
-0.039175335,
0.010302436,
0.0012780236,
0.011932568,
0.02428245,
0.012930209,
-0.0061488585,
-0.019170355,
0.00788332,
-0.014632067,
-0.042226944,
-0.04081851,
0.012467251,
-0.025038831,
0.0036123728,
-0.0087896725,
0.0049295197,
-0.023160918,
0.0072508277,
-0.0112087885,
0.0020816787,
0.001874652,
-0.013536617,
0.008581016,
0.012467251,
0.009467808,
-0.00027589986,
0.0029815116,
-0.015492776,
0.0030287856,
-0.004535028,
-0.0130345365,
0.004746945,
0.030046597,
0.027803535,
-0.008131099,
0.00009439484,
0.0065400903,
0.020200597,
0.0038568927,
-0.015623187,
-0.0006561282,
0.036958355,
-0.008281072,
-0.022495825,
-0.021348212,
-0.0076485802,
0.025482226,
0.0328113,
-0.010778434,
-0.020787446,
0.0009242849,
-0.002847841,
0.016979456,
-0.00050126563,
-0.0003341771,
0.004834972,
-0.030646484,
-0.008496249,
-0.021987222,
-0.027568795,
0.0037590847,
-0.036045484,
0.010719749,
-0.009422164,
0.0015755227,
0.027047154,
0.048330158,
0.00715302,
-0.02822085,
0.008411482,
-0.032472234,
0.050390646,
0.00088271656,
-0.008724468,
-0.015688391,
0.022991383,
-0.026734168,
-0.037532162,
0.00095362734,
0.008483208,
0.0022153496,
-0.032837383,
0.017214196,
0.00082362426,
0.016809924,
0.0077268267,
0.01381048,
0.0040166457,
0.024386777,
-0.022026345,
-0.01109794,
0.013419248,
-0.010797995,
0.0067552677,
0.02725581,
0.005757627,
0.0021012404,
-0.009682985,
0.009220027,
-0.0026587455,
0.0039873035,
-0.014292999,
-0.020004982,
0.037271343,
0.006644419,
0.028872902,
-0.014319081,
-0.016809924,
-0.01751414,
0.027777452,
0.0024109655,
-0.016262198,
-0.0079159215,
0.024112916,
0.022913137,
0.02232629,
-0.0224567,
-0.02232629,
-0.0040166457,
-0.008867919,
-0.04217478,
0.0042253025,
-0.0022088292,
0.02404771,
0.026395101,
-0.02021364,
-0.012552017,
0.00052367995,
-0.04191396,
-0.022547988,
0.009050494,
0.018700877,
0.0026994988,
0.031637605,
0.016496938,
-0.0008313674,
-0.0019528983,
0.005509847,
-0.044965565,
-0.017553262,
0.019261641,
-0.025443103,
0.0296032,
0.019887613,
-0.008105017,
-0.006611816,
0.02676025,
-0.00592064,
-0.013217112,
0.02455631,
0.0049034376,
0.020748323,
-0.018309645,
0.020187557,
0.019222518,
0.0005118615,
0.037219178,
-0.004254645,
-0.0015119476,
-0.0014654888,
0.0049001775,
0.009533013,
-0.014527738,
-0.013823521,
0.008489728,
0.028194766,
-0.02651247,
-0.025990827,
0.01714899,
-0.012636784,
-0.0033971954,
-0.00074782316,
0.0041535767,
0.015492776,
-0.01047849,
-0.002896745,
-0.02330437,
-0.016366526,
-0.011580459,
0.010811036,
-0.0038210298,
-0.001628502,
-0.0017148991,
0.009174384,
-0.001923556,
-0.008574495,
0.0010758872,
0.0012747634,
-0.018466137,
-0.0063477345,
0.02209155,
0.02183073,
-0.010145943,
-0.013784397,
0.0011133803,
-0.03635847,
0.012871523,
-0.012421607,
-0.026916742,
-0.02403467,
-0.0035439073,
0.002686458,
-0.007955045,
-0.016796881,
-0.017357647,
-0.053833485,
-0.010726269,
0.030124843,
0.18904316,
-0.024217244,
-0.019587668,
0.02676025,
0.019405093,
-0.00081343594,
0.01862263,
0.022248045,
-0.00036066675,
0.005291409,
-0.002701129,
0.005389217,
-0.014632067,
0.0046426165,
0.024804091,
-0.008418002,
-0.045435045,
-0.012545497,
0.009448246,
0.004685,
0.004476343,
-0.019405093,
-0.02404771,
-0.0046719587,
0.016627349,
0.00875707,
-0.035002198,
0.0037297425,
-0.00055709766,
0.007720306,
-0.0037199617,
0.022182839,
-0.010328517,
0.011058817,
-0.016744718,
0.01630132,
-0.000009959089,
-0.011958649,
0.013171468,
0.01714899,
-0.001196517,
0.008339756,
-0.006696583,
-0.028038273,
-0.017918414,
0.006514008,
0.00035557259,
0.0032733055,
-0.024360696,
-0.015884008,
-0.02996835,
0.017944494,
0.013771357,
0.023030508,
-0.0033841543,
0.013914809,
0.01787929,
-0.012493333,
0.0014883106,
-0.0025984307,
0.008254989,
0.0075507723,
-0.017579345,
0.009943807,
-0.0111305425,
0.02330437,
-0.009324356,
0.009363479,
0.010908845,
-0.021230841,
0.012343361,
-0.025482226,
-0.01369311,
-0.009057014,
-0.009337397,
-0.013393166,
0.03946224,
0.006683542,
0.0064814053,
0.024491105,
0.0092656715,
-0.016366526,
-0.020135393,
0.011808678,
-0.019809367,
-0.03787123,
0.013132345,
0.005711983,
-0.017618468,
-0.006328173,
-0.007387759,
0.0025087735,
0.007296472,
-0.016496938,
-0.000023993509,
-0.013980013,
-0.014853764,
0.00044787882,
-0.017944494,
-0.026199484,
-0.0062368857,
0.06583126,
-0.011684787,
0.006510748,
-0.0041535767,
-0.009441726,
-0.010061176,
0.000529793,
0.027334057,
0.011743472,
0.008620139,
-0.050260235,
0.0014630436,
-0.011254433,
0.0030988813,
0.0066770213,
0.03221141,
-0.024491105,
0.01789233,
-0.025077954,
-0.0074203615,
-0.005832613,
0.03095947,
0.021739442,
-0.01134572,
0.019405093,
0.010758872,
-0.0074920873,
-0.0056532985,
-0.023904258,
0.009057014,
-0.014997216,
-0.0015021669,
-0.0053598746,
-0.004649137,
-0.022169797,
0.004378535,
0.0044828635,
-0.011645664,
0.02947279,
-0.0012005924,
-0.019209478,
-0.014032178,
-0.010432846,
0.026603756,
-0.012525936,
0.022534948,
0.030594321,
-0.012910646,
0.0029701008,
-0.0060445303,
-0.0037721258,
-0.009141781,
0.012969332,
0.023382615,
0.00010101726,
-0.01862263,
-0.043739706,
-0.00444048,
0.022469742,
-0.009474328,
0.0046556573,
0.025560472,
-0.023995545,
-0.006321653,
0.010674106,
-0.16410866,
0.019665916,
0.023865135,
-0.03886235,
0.007074774,
0.013927849,
0.0033971954,
-0.011645664,
0.022626234,
-0.0017034882,
0.024165079,
0.0035862909,
-0.009141781,
-0.008913563,
-0.0021599252,
-0.022782728,
-0.025312692,
0.0360194,
0.017722797,
0.010315476,
0.014123465,
-0.0042155217,
0.011547856,
-0.009480849,
0.007785511,
0.029368462,
0.0017605427,
0.02565176,
-0.009187425,
-0.020813528,
-0.009917724,
-0.00036209312,
0.018792164,
-0.008437565,
-0.0043133297,
0.0046393564,
-0.006132557,
-0.012486813,
0.0020327747,
-0.008157182,
0.039410077,
0.038314626,
0.008867919,
-0.00019551397,
-0.0059402017,
0.012291197,
0.022391496,
-0.015388448,
0.017605428,
-0.0026571155,
-0.011189227,
-0.0008162887,
0.029159805,
0.011932568,
0.016705595,
0.00053223816,
-0.0016904471,
0.011678267,
-0.0009503671,
-0.021256924,
0.0029521694,
-0.023069631,
0.038314626,
-0.005760887,
0.009167863,
-0.00887444,
-0.021256924,
0.0048088897,
-0.011241391,
-0.0102959145,
-0.024230285,
0.009135261,
0.016666472,
0.00032908292,
0.01630132,
0.02614732,
0.004365494,
0.011893445,
0.0115674175,
-0.0014369615,
-0.0064651044,
0.0023245686,
-0.012023855,
-0.00629231,
0.012675907,
0.012089061,
0.016496938,
0.01987457,
0.0007991723,
-0.0016553992,
0.017722797,
-0.026421182,
0.01776192,
-0.011039255,
0.014371245,
-0.0048023695,
0.004264426,
0.008907042,
0.023591273,
0.005773928,
-0.011293556,
-0.013797439,
-0.025743047,
0.018270522,
0.039383993,
-0.023291329,
-0.00406881,
0.011919526,
0.0027125399,
-0.0018616109,
-0.00033275073,
-0.007994168,
-0.008359318,
0.020670077,
-0.0073421155,
0.022743605,
-0.02552135,
-0.025938664,
0.016718635,
-0.0047176024,
0.045982767,
-0.0058912975,
-0.0004429884,
0.016001377,
-0.0070878146,
-0.010954488,
-0.10651936,
-0.014071301,
0.004658918,
0.0119651705,
0.012134704,
0.037062686,
-0.014775518,
0.01664039,
-0.013106262,
0.049764674,
-0.02159599,
-0.031898428,
-0.0016937073,
0.007622498,
0.0022055688,
-0.001319592,
0.010895804,
-0.012486813,
-0.008894001,
0.036671452,
0.02156991,
-0.020018023,
-0.005079492,
-0.019079067,
0.0024973624,
-0.010947968,
-0.034506638,
0.0039057967,
0.003095621,
0.0035732498,
0.015818803,
-0.005773928,
0.006807432,
-0.011997772,
-0.017931454,
-0.0075442516,
-0.012349881,
-0.005451162,
0.008196305,
0.035184775,
0.0012845441,
0.0135627,
-0.0004552144,
-0.007752909,
-0.012858483,
-0.003713441,
-0.010041614,
-0.008809234,
0.010804516,
-0.022026345,
0.0029293476,
-0.017853208,
-0.03860153,
-0.013888726,
-0.017501099,
-0.021426458,
0.004365494,
0.015466694,
0.012910646,
0.0020555968,
0.027803535,
0.00554897,
-0.012480292,
0.0051707793,
0.009572136,
-0.021361252,
0.00579675,
-0.03648888,
-0.013797439,
-0.029211968,
-0.02553439,
0.03158544,
-0.0005379436,
0.0037884272,
-0.012669387,
-0.007824634,
-0.041600972,
-0.026708085,
0.020070188,
-0.048173666,
-0.010393723,
-0.022052428,
0.021609033,
-0.024165079,
0.0012788387,
0.00084929884,
-0.0010824078,
0.00715302,
-0.009291753,
-0.022130674,
-0.017605428,
0.03168977,
0.012089061,
-0.015544941,
-0.011873883,
0.020891774,
-0.0036580167,
-0.013014975,
0.009722108,
-0.017422853,
-0.021256924,
0.013151906,
-0.052112065,
0.005711983,
0.00899833,
-0.019470299,
-0.0044470006,
-0.024373736,
0.011234871,
-0.0052229436,
-0.011554377,
0.01147613,
-0.0067161447,
0.01664039,
-0.018231397,
-0.02232629,
-0.013217112,
-0.01639261,
0.021935059,
0.0087505495,
0.03182018,
0.021974182,
0.013177988,
0.01789233,
0.014853764,
0.017305484,
-0.0074464437,
0.0012283046,
-0.02651247,
0.034558803,
-0.028377341,
-0.022508865,
0.014866806,
-0.024725845,
-0.026395101,
0.011163145,
-0.03153328,
-0.021478621,
0.010902324,
-0.0024028148,
0.040896755,
0.02072224,
-0.011632623,
-0.0010343188,
-0.020070188,
-0.000102596445,
-0.0033580724,
0.015584064,
-0.0077724704,
-0.003144525,
0.012819359,
-0.012675907,
0.03268089,
0.014840723,
0.013021496,
-0.032628726,
-0.016549101,
0.0005721764,
0.013667028,
0.019235559,
0.007968086,
-0.02996835,
0.026616799,
0.010406764,
0.03171585,
-0.013627905,
0.0046393564,
-0.007863757,
-0.0026571155,
0.016170911,
0.00021252848,
-0.04183571,
-0.005871736,
0.010022053,
0.008548413,
0.012565059,
0.0021061308,
-0.009154823,
0.006155379,
0.007537731,
0.0046067536,
0.032628726,
-0.008887481,
0.013008455,
-0.009787314,
0.016105706,
0.022521906,
-0.022208922,
-0.028794656,
0.0004723308,
0.010413284,
0.027177563,
-0.012265114,
0.013367084,
0.007289951,
0.005698942,
0.023265246,
0.030568238,
-0.017122908,
-0.0031640865,
0.01664039,
0.007609457,
-0.0067617884,
-0.0013587151,
-0.011124022,
-0.01885737,
-0.014866806,
0.004476343,
-0.016562143,
-0.029133722,
-0.003974262,
0.00023596163,
0.014879847,
0.04488732,
-0.032002755,
-0.010517613,
-0.012134704,
0.008183263,
-0.001874652,
-0.012278155,
-0.009826437,
0.009650382,
0.013706151,
0.013393166,
-0.020278845,
0.0102959145,
0.018192274,
0.0013546399,
0.009096137,
-0.011430487,
0.028559916,
-0.022117633,
0.01109794,
0.012904126,
-0.004922999,
0.0056532985,
-0.009220027,
-0.010621942,
0.007198664,
0.00046581027,
0.0067748292,
0.07099552,
0.0011899965,
0.015740557,
0.015544941,
-0.0017148991,
0.035341267,
0.017201155,
0.0014231054,
-0.020996103,
-0.016588226,
-0.0055880933,
-0.044600416,
-0.0029537994,
-0.0251562,
0.0006866932,
0.032341823,
0.019183395,
0.014436451,
-0.0068269935,
-0.024582393,
-0.0053989976,
-0.01307366,
0.03870586,
0.01060238,
-0.016822964,
-0.0058489144,
0.040479444,
0.02601691,
-0.0051349164,
-0.03797556,
-0.0020637473,
-0.004303549,
-0.025560472,
0.0053272718,
0.012904126,
-0.021922018,
0.011632623,
-0.016562143,
0.0153362835,
0.001936597,
0.01630132,
-0.03095947,
-0.00937652,
0.0027484028,
0.025390938,
-0.0005876626,
-0.012610703,
-0.014292999,
-0.028898982
] |
Nucleosomes, the fundamental units of chromatin structure, are regulators and barriers to transcription, replication and repair. Post-translational modifications (PTMs) of the histone proteins within nucleosomes regulate these DNA processes. Histone H3(T118) is a site of phosphorylation [H3(T118ph)] and is implicated in regulation of transcription and DNA repair. We prepared H3(T118ph) by expressed protein ligation and determined its influence on nucleosome dynamics. We find H3(T118ph) reduces DNA-histone binding by 2 kcal/mol, increases nucleosome mobility by 28-fold and | [
-0.02583732,
0.0038906503,
-0.0023232647,
-0.013743256,
-0.020222219,
0.027722111,
-0.01602071,
0.010425242,
-0.003946278,
-0.00020747817,
0.0023216286,
0.003242754,
-0.0018733366,
0.00593905,
0.007931822,
-0.00812161,
0.022499673,
-0.033638254,
-0.02409651,
-0.010994605,
-0.025680255,
0.00090149214,
-0.0030709633,
-0.01811492,
-0.007866378,
0.022368785,
0.019122759,
-0.028298019,
0.0043520313,
-0.014764183,
-0.0037761233,
0.0114919795,
-0.009509024,
0.006020855,
-0.0075391578,
0.0053696865,
0.00933887,
-0.010732829,
0.013075726,
-0.002248004,
0.009705356,
0.0041229767,
0.0057623507,
-0.0007685589,
-0.006439697,
-0.010451419,
0.042172164,
0.000114118106,
-0.014109743,
0.021727433,
-0.0038775615,
0.02638705,
0.0009808431,
-0.007872922,
-0.016426463,
-0.018154187,
0.018023299,
0.027434157,
0.00022414596,
-0.008403019,
0.0035830631,
-0.0153531805,
-0.016819127,
0.015117582,
0.0050195605,
-0.008795684,
0.008939661,
0.0038644727,
-0.003661596,
0.0022185543,
0.028036242,
0.022813804,
-0.02041855,
-0.017486658,
0.020444728,
-0.03146551,
-0.020641062,
-0.0063349865,
0.005183171,
0.017525924,
0.02926659,
-0.012434375,
-0.0020925743,
0.0077813007,
0.0216489,
0.0058866944,
0.012545629,
-0.011112404,
0.020457817,
-0.005651096,
0.02816713,
0.04274807,
0.036831927,
0.007990722,
-0.022839982,
0.023494422,
-0.012408197,
0.02386091,
0.010922616,
-0.019306002,
-0.028638327,
0.018821716,
-0.036517795,
-0.0154186245,
-0.04450197,
-0.009764256,
0.025431568,
-0.019018048,
-0.0006564859,
-0.017761523,
-0.022408051,
0.023887089,
-0.014711828,
-0.035392158,
0.0435334,
-0.008232865,
-0.00044747387,
-0.013533835,
0.0024705138,
-0.008664795,
0.022774538,
0.047905065,
0.010700107,
-0.027381802,
0.010124198,
0.015104493,
-0.0077093123,
-0.0070417826,
-0.0068781725,
0.008173965,
-0.003291837,
0.0075522466,
0.00084668276,
0.0020304024,
-0.028873926,
0.0071726707,
-0.0029269862,
-0.022696005,
-0.043611933,
-0.050653715,
0.018402874,
0.030523118,
-0.016426463,
-0.0018357063,
0.024161953,
0.022172453,
0.007336281,
0.011197481,
-0.0018651561,
0.0031249546,
0.014188276,
0.01232312,
0.019515423,
0.038716715,
0.002923714,
0.012715784,
-0.007225026,
0.021360947,
-0.011145126,
-0.027774466,
-0.0066229403,
-0.0077485787,
0.014476229,
0.0112171145,
0.02730327,
0.023612222,
0.002907353,
0.00227909,
-0.017931677,
0.0017702623,
-0.0033736422,
0.0016410102,
-0.014751094,
0.009142538,
-0.012611073,
0.013494569,
-0.00051782624,
0.027355624,
-0.02442373,
-0.02009133,
-0.023350446,
0.006312081,
0.032093775,
0.009757712,
-0.005844156,
0.009397769,
0.01039252,
-0.027905354,
0.007048327,
-0.015601868,
0.0004560634,
-0.0021940127,
-0.006721107,
-0.01878245,
-0.62868196,
-0.026334696,
0.014567851,
-0.025981298,
0.006112477,
0.022107009,
0.02341589,
0.0016884572,
-0.033167057,
0.0042800424,
0.010929161,
0.0133571355,
0.012866305,
-0.016112331,
-0.036543973,
-0.03701517,
-0.008298309,
-0.012656884,
0.033873852,
-0.0041066157,
-0.024462996,
-0.014973604,
0.0020287663,
0.0033540088,
0.021753611,
0.00091294484,
0.028952459,
0.011825744,
-0.016963104,
0.018834805,
-0.028978636,
0.011158215,
-0.004819956,
0.015287736,
0.038166985,
0.0017244514,
-0.0047152457,
0.017316502,
0.026805893,
0.021858322,
0.0036354184,
-0.024698595,
0.017591368,
0.020850483,
0.002890992,
0.004767601,
-0.019279825,
-0.0017882594,
0.0056118295,
-0.015366269,
0.006361164,
-0.004669435,
-0.009738078,
0.021020638,
-0.011950089,
0.0142668085,
0.015981443,
-0.014646384,
0.0017162709,
0.006485508,
0.007814023,
0.0057787118,
-0.008579718,
-0.018690828,
-0.027093848,
-0.00054604904,
-0.0037074068,
0.027669756,
0.00011186847,
0.0015322095,
-0.00036198754,
0.031989064,
0.0057394453,
-0.011256381,
-0.008298309,
0.025654078,
0.011550879,
0.0061844653,
-0.015758933,
0.025274502,
-0.005618374,
-0.0074606244,
-0.02607292,
-0.01425372,
0.01910967,
0.0043323976,
-0.019253647,
0.029973386,
0.0028451812,
0.0053860475,
-0.0010062027,
-0.004689068,
0.010340164,
-0.024777127,
-0.03094196,
0.018075654,
0.01747357,
-0.00475124,
0.0063382587,
-0.005461308,
-0.017133258,
0.004512369,
-0.005559474,
0.0023985254,
0.02518288,
-0.00452873,
-0.019816466,
0.030915782,
0.048795104,
0.0020287663,
0.011334914,
0.0027535595,
-0.020510172,
-0.0065738573,
-0.005392592,
-0.023442067,
0.03400474,
0.009914777,
-0.022080831,
-0.01121057,
0.02133477,
0.014188276,
0.0022201904,
-0.0047643287,
0.02341589,
0.022944693,
0.024148865,
0.0022758178,
-0.011609779,
0.003309834,
0.016361019,
0.009404314,
0.025549367,
-0.036753394,
0.0237562,
0.022107009,
0.022264075,
-0.010143831,
0.029947208,
-0.025038904,
-0.030339874,
-0.0038415673,
0.0127092395,
0.014436963,
-0.017957855,
-0.043926064,
-0.024188131,
0.00023825734,
0.010261631,
0.009234159,
0.002760104,
0.012525996,
-0.0076307794,
0.0005730447,
0.0012131695,
0.009823156,
-0.0067800065,
-0.03248644,
-0.006194282,
-0.0127092395,
-0.016622795,
0.014070476,
-0.010752462,
0.004977022,
-0.0041197045,
-0.03691046,
0.0044371085,
0.010516863,
-0.011891189,
-0.025667166,
0.009823156,
-0.0011739031,
-0.039187912,
-0.007061416,
-0.01049723,
0.03646544,
0.011923911,
0.002810823,
-0.0055627464,
0.0015714759,
-0.016033798,
-0.009653001,
-0.027093848,
-0.008088888,
0.025104348,
0.027565045,
0.023154113,
0.00668184,
0.020457817,
0.016478818,
0.0048592226,
-0.0025899494,
0.0029727973,
0.007984177,
0.008638618,
-0.0313608,
0.025130525,
0.004787234,
-0.014790361,
0.017591368,
0.00828522,
0.0064953244,
-0.00022925877,
-0.0393188,
0.009391225,
-0.029554544,
-0.00712686,
-0.01801021,
-0.011851923,
0.0037761233,
-0.0068650837,
-0.008560085,
-0.017237969,
-0.011145126,
-0.021635812,
0.020169863,
-0.029790143,
0.0042996756,
-0.013664723,
-0.010732829,
0.025549367,
-0.0105364965,
0.0355754,
-0.0014692195,
-0.010026032,
0.0060732104,
0.023010137,
0.008533907,
-0.001365327,
0.011459257,
-0.021622723,
0.014175187,
-0.010071843,
0.0036845014,
0.010484141,
0.01153779,
0.025222147,
-0.008036532,
0.04062768,
0.0026292158,
0.0027241097,
-0.003952822,
-0.019463068,
-0.04133448,
0.010582307,
-0.0062237317,
0.029397478,
0.0053238757,
0.00040861644,
0.009155626,
-0.00004034014,
-0.0002151474,
-0.0011518158,
0.008586262,
0.014463141,
-0.009188348,
0.010130743,
0.018913338,
0.029999563,
0.0049541164,
0.015628045,
-0.006701473,
0.001621377,
-0.0023739839,
0.0018029843,
-0.022447318,
0.011544335,
-0.000980025,
-0.0054842136,
-0.008861128,
-0.020942105,
0.018795539,
0.017185614,
-0.028428907,
-0.0014741278,
0.000594314,
0.011799566,
0.015562601,
0.010222364,
0.015209204,
-0.028769216,
-0.031439334,
0.027591223,
0.025667166,
-0.015104493,
-0.009849333,
-0.027015315,
-0.01780079,
-0.0127092395,
0.01823272,
-0.007689679,
0.003497986,
0.0004846952,
-0.013900322,
-0.031832,
-0.006668751,
0.020065153,
-0.010039121,
0.01502596,
-0.0041327933,
-0.0036517794,
0.013494569,
-0.012611073,
-0.011138582,
0.011223659,
0.02264365,
0.010772095,
-0.015641134,
-0.013029915,
-0.00745408,
0.012552174,
0.002967889,
0.019908087,
-0.025248324,
-0.0017277236,
-0.003645235,
0.008992016,
0.00917526,
0.024240486,
-0.005215893,
-0.024004888,
0.0005395046,
-0.0034652639,
0.017421214,
0.022460407,
0.0257457,
0.0019469613,
0.015916,
-0.0047087013,
0.007159582,
-0.015667312,
-0.023716934,
0.022486584,
-0.01547098,
0.008802229,
0.0154186245,
-0.010111109,
0.009266881,
-0.0026832072,
0.006806184,
0.0034390863,
-0.017133258,
-0.012355842,
0.0060306718,
0.008409563,
-0.01088335,
0.016622795,
0.032329373,
0.024737861,
-0.013900322,
0.012984104,
0.023350446,
0.010549585,
-0.026360873,
0.00044052044,
-0.0056118295,
0.010098021,
0.007277381,
-0.014620206,
-0.02981632,
0.010785184,
0.022054654,
0.01679295,
-0.006083027,
-0.0075391578,
0.023612222,
0.024253575,
0.022368785,
-0.00001492943,
0.0022660012,
0.030758716,
0.018429052,
-0.02409651,
0.01021582,
0.011033871,
-0.02088975,
-0.021779789,
-0.028978636,
0.0047774175,
-0.024070332,
0.004993383,
-0.027826821,
-0.0007260202,
-0.015379358,
-0.011799566,
-0.02795771,
0.016073065,
-0.002424703,
-0.025614811,
-0.0031511323,
0.0030235164,
-0.021701256,
-0.015588779,
-0.00828522,
0.015523335,
-0.032067597,
-0.04725062,
-0.007964544,
0.0355754,
0.029135702,
0.016112331,
-0.022355696,
-0.0059030554,
0.0276174,
-0.015562601,
-0.011204026,
-0.012820494,
-0.014345341,
0.0015207567,
-0.0084422855,
0.010418697,
-0.012179143,
-0.014868894,
-0.006047033,
0.005441675,
-0.021635812,
0.025169792,
0.0005255977,
-0.03424034,
0.021491835,
0.019384535,
0.034894783,
0.005801617,
0.0051733544,
-0.028010065,
-0.024541529,
-0.020575618,
-0.02706767,
0.012460552,
-0.0050653713,
0.0067341956,
0.021347858,
-0.009064005,
-0.012728873,
0.024908016,
-0.006871628,
-0.004080438,
0.022224808,
0.010418697,
0.0063186255,
-0.019162025,
0.007277381,
-0.027565045,
-0.006047033,
-0.008239409,
-0.01336368,
0.025038904,
-0.011930455,
-0.01811492,
0.0061517432,
0.004211326,
-0.008154332,
0.0068781725,
-0.015039049,
-0.01667515,
0.0393188,
-0.011073138,
-0.020261485,
0.0015485705,
-0.033376478,
-0.012859761,
-0.009849333,
0.012257676,
-0.0055463854,
-0.005736173,
-0.019044226,
-0.0053827753,
-0.015536424,
-0.015156848,
-0.030156631,
-0.010935705,
0.019397624,
0.00018498176,
0.014070476,
-0.004963933,
0.0018209814,
-0.02276145,
-0.021020638,
-0.0153531805,
-0.042512473,
0.0059815887,
0.0002472559,
0.033481188,
0.015850555,
0.040156484,
0.013468391,
0.0010626481,
0.027879177,
0.024554618,
-0.006079755,
-0.013160803,
0.026151452,
-0.0153531805,
0.011289103,
0.009299603,
-0.015549513,
0.014960515,
-0.008651706,
0.021753611,
0.01700237,
-0.007015605,
-0.020379284,
0.02740798,
-0.03455447,
-0.03369061,
0.008756418,
-0.019751022,
-0.019803377,
-0.02475095,
-0.0010520135,
0.006069938,
-0.003965911,
0.03225084,
-0.010798273,
0.02475095,
-0.005984861,
0.009096727,
-0.014986693,
0.009070549,
-0.0020860299,
-0.001332605,
0.0008589535,
0.015274648,
0.036543973,
-0.0019404169,
0.027669756,
-0.01645264,
-0.0030627828,
-0.015431713,
0.012120243,
-0.023586044,
-0.016282486,
-0.027800644,
-0.018075654,
-0.0071857595,
-0.013638546,
0.00065362273,
-0.05403063,
0.0034161808,
-0.0046988847,
0.0023150842,
0.010431786,
0.0033540088,
0.012597985,
0.042015098,
0.00018804947,
0.013560013,
-0.014567851,
0.00806271,
0.015497157,
0.017054725,
-0.026256163,
-0.033481188,
-0.029973386,
0.020457817,
0.029423656,
0.008049621,
-0.020863572,
-0.01027472,
-0.0070548714,
0.015758933,
0.0010536496,
-0.037826676,
-0.015510246,
-0.018389786,
-0.001798076,
0.0035568855,
0.010405608,
-0.016976193,
-0.0015951993,
-0.0019502335,
0.03248644,
-0.0031920348,
-0.0001059376,
-0.011426535,
0.019122759,
0.006262998,
0.011118948,
-0.0045483634,
-0.0081674205,
0.014672562,
-0.017303413,
0.0058866944,
0.009103271,
-0.013010282,
0.029318945,
-0.015667312,
-0.007866378,
0.01700237,
0.006701473,
0.000610266,
-0.0014814903,
-0.0020696688,
0.0395544,
-0.024240486,
0.009247248,
0.02066724,
0.02219863,
-0.013638546,
-0.008357208,
0.004525458,
-0.013344047,
-0.028847748,
0.0070090606,
0.013232792,
0.010562674,
-0.022146275,
-0.025575545,
-0.015091404,
0.01232312,
-0.03413563,
-0.0005566837,
0.003995361,
-0.044161662,
-0.04243394,
0.022604384,
0.028140953,
0.033167057,
0.01159669,
-0.002743743,
-0.012054799,
0.037931386,
-0.0052224374,
-0.006328442,
0.010209275,
-0.005454764,
-0.004947572,
0.010019488,
-0.021727433,
-0.022264075,
0.017133258,
-0.019620134,
-0.02507817,
0.00256868,
0.0034259974,
0.040575325,
0.025248324,
-0.0040509882,
0.014463141,
0.0050391937,
0.02595512,
0.012558718,
-0.0089134835,
0.012846672,
-0.043376334,
0.015641134,
0.013291691,
-0.016400285,
-0.031439334,
0.003193671,
-0.04073239,
0.030261341,
-0.00674074,
0.006262998,
-0.0030627828,
0.0084422855,
-0.009489391,
-0.0008385022,
0.010379431,
-0.033742964,
-0.008147787,
-0.0017473568,
-0.023232646,
0.016046887,
-0.02307558,
0.008075799,
0.020261485,
-0.004208054,
-0.019449979,
-0.0011354547,
0.007787845,
-0.04429255,
-0.040994167,
0.0053206035,
-0.0195416,
0.017277235,
0.011262925,
-0.015405536,
-0.0119631775,
-0.01348148,
-0.06680531,
-0.021230059,
-0.009410858,
-0.010641207,
0.0074148136,
0.012669973,
-0.010202731,
-0.01275505,
-0.0006466693,
0.016203953,
0.0061746486,
-0.032172307,
0.0092865145,
-0.024227398,
0.013239336,
0.018494496,
-0.01921438,
0.010595396,
0.032119952,
-0.00089003943,
-0.011092771,
0.018612295,
-0.010641207,
0.022826893,
-0.022735272,
0.011694856,
-0.0057754396,
0.030078098,
0.025431568,
-0.024345197,
-0.012277309,
-0.010104565,
0.00010788047,
-0.042381585,
0.012094066,
-0.0138610555,
0.0015338456,
-0.002841909,
-0.0077289455,
-0.026884427,
0.016701328,
-0.019567778,
0.02408342,
0.010804817,
0.0072970144,
0.007179215,
0.012617618,
-0.012198776,
-0.011132037,
-0.0074802577,
-0.01425372,
-0.01855994,
-0.002614491,
-0.025012726,
-0.016308663,
0.006505141,
0.0011501797,
-0.01425372,
-0.008677884,
0.017813878,
-0.022656739,
-0.042512473,
0.007866378,
-0.0010691925,
-0.016884571,
0.0037695789,
-0.030994315,
-0.026256163,
-0.0035274357,
0.012048255,
-0.022120098,
-0.014816538,
0.01677986,
0.0015992896,
-0.0017882594,
0.011145126,
0.012807406,
-0.0041066157,
-0.010412153,
0.01746048,
0.19287679,
-0.006387342,
-0.028585972,
-0.00085649936,
0.026099097,
0.0005472761,
0.007997266,
0.0027731927,
-0.019188203,
-0.0033163785,
0.026033653,
0.0115247015,
-0.034790073,
0.0037237678,
0.022159364,
-0.016950015,
-0.024986548,
-0.0078402,
-0.039240267,
0.024135776,
0.014489318,
-0.0030840521,
-0.0009006741,
0.010039121,
0.02528759,
-0.017735345,
-0.012964471,
-0.00042906773,
-0.01712017,
0.01623013,
-0.032879103,
0.0060110386,
0.0077616675,
-0.020366196,
0.010294354,
0.0023478062,
-0.0139264995,
0.00035421606,
-0.010045665,
-0.0047577843,
0.0016451004,
-0.0075391578,
-0.013874144,
-0.02031384,
0.012951382,
-0.0039037392,
0.0022038294,
0.01943689,
-0.03324559,
0.004011722,
-0.03201524,
-0.0045974464,
0.017604457,
0.031544045,
-0.012689606,
-0.0108768055,
-0.0040542604,
0.008756418,
-0.0045843576,
0.029240413,
-0.01734268,
0.0005399136,
-0.014476229,
0.003164221,
-0.00078778306,
0.028376551,
-0.017840056,
-0.00017281326,
0.021570368,
-0.03146551,
0.02519597,
0.029502189,
-0.017918589,
-0.013599279,
0.0012565262,
-0.013756345,
0.05492067,
0.0066458457,
0.032512616,
0.012048255,
0.0041197045,
-0.013429124,
-0.010241997,
0.00375649,
0.020837395,
-0.029318945,
0.029999563,
0.000046194313,
-0.00314786,
-0.0255101,
0.015065227,
0.0012835219,
-0.029214235,
0.006995972,
0.004325853,
-0.0040673492,
0.00007137495,
0.010045665,
-0.021936854,
0.002648849,
-0.0331147,
0.075496286,
-0.0016017437,
0.028245663,
0.004607263,
0.0022987232,
0.012408197,
0.0016598253,
-0.0006024945,
-0.023468245,
0.017146347,
-0.015772022,
0.029790143,
0.010968427,
0.007990722,
0.010320531,
-0.0057885284,
-0.021609634,
0.043009847,
-0.0077158567,
0.0028353645,
-0.019018048,
0.011891189,
0.030025743,
-0.0078271115,
-0.007872922,
-0.02420122,
0.0040837103,
-0.015392447,
-0.03798374,
-0.00006769371,
0.0022660012,
0.004077166,
0.007336281,
-0.02629543,
-0.031779643,
0.0058245226,
0.0027044765,
-0.022120098,
0.04287896,
-0.012080977,
-0.014999782,
0.0005697725,
0.00314786,
-0.005170082,
-0.011865011,
-0.019162025,
0.009397769,
-0.010425242,
-0.012296942,
-0.0053336923,
0.00017434711,
0.0021727434,
0.02827184,
0.008697518,
-0.014057388,
-0.017185614,
-0.045679964,
-0.031177558,
0.026439406,
-0.027041493,
0.014698739,
0.0038415673,
-0.003048058,
-0.0023887088,
0.020078242,
-0.16282485,
0.01655735,
0.02221172,
-0.021675078,
0.0257457,
0.025313769,
0.034371227,
-0.013717079,
-0.0023330813,
-0.001204171,
-0.0019616862,
0.0015682037,
-0.042695716,
-0.04717209,
0.009522113,
0.0043160366,
0.009299603,
0.01689766,
0.018599207,
0.0020042248,
-0.009535202,
-0.0005971772,
0.025483923,
-0.0057721674,
-0.0023249008,
0.034161806,
-0.010935705,
-0.0016737322,
0.0026046743,
-0.010484141,
0.000048316135,
0.0021351129,
0.0063807974,
-0.0011992627,
0.024777127,
0.015405536,
0.009214526,
-0.017172525,
0.011158215,
0.023900177,
0.0196594,
0.012617618,
0.010313987,
-0.012067888,
-0.0013735075,
0.028847748,
0.008232865,
0.00044256556,
0.027983887,
-0.0016835489,
0.022185542,
0.0009121268,
0.018808628,
0.035523046,
0.02916188,
0.015916,
-0.024017977,
0.013834878,
-0.008180509,
-0.0042996756,
-0.01590291,
0.00091294484,
0.039187912,
-0.008259042,
-0.01297756,
-0.037303124,
-0.013383313,
0.0031429518,
-0.03743401,
-0.00018273212,
-0.0040706214,
-0.01336368,
0.0013064274,
-0.014502407,
0.0069239833,
0.016138509,
-0.0052257096,
0.0061550154,
0.006616396,
0.02583732,
-0.008900395,
0.005510391,
-0.025418479,
-0.03039223,
-0.009168715,
-0.010071843,
-0.01314117,
0.022146275,
-0.00922107,
0.005425314,
0.0092865145,
-0.008579718,
0.02518288,
-0.008344119,
0.043009847,
0.015706578,
-0.010340164,
-0.002905717,
-0.018271986,
-0.012584896,
0.012493274,
-0.020353107,
-0.008900395,
0.01458094,
0.040051773,
0.023900177,
-0.017159436,
0.017185614,
0.04785271,
-0.006069938,
-0.019567778,
-0.0038121175,
0.013874144,
0.033402655,
0.0037008624,
0.02066724,
0.016858393,
-0.00039798178,
-0.008298309,
0.0021302046,
0.061726853,
-0.0019191476,
-0.011158215,
0.011145126,
0.0013072455,
-0.04211981,
-0.12868923,
-0.005294426,
-0.014973604,
0.023965621,
-0.0007558791,
0.012395108,
0.0020025887,
0.0149474265,
0.0070090606,
0.036858104,
-0.035994243,
0.015209204,
0.010745917,
0.0026717545,
-0.0015665676,
0.017970944,
0.004816684,
-0.025876587,
-0.011629412,
0.038193163,
0.0034914415,
0.0024181586,
-0.0059946775,
-0.025680255,
0.028926281,
-0.017198702,
-0.027852999,
0.017525924,
0.022709094,
0.013651635,
-0.013507658,
-0.016217042,
0.0036386906,
-0.012480185,
-0.009005105,
-0.0021776517,
0.00433567,
-0.0032394817,
0.0415439,
0.010490686,
-0.015994532,
0.00030799618,
0.019515423,
-0.00039143738,
0.02730327,
-0.016910749,
-0.025811143,
0.0019289642,
0.015654223,
0.008802229,
-0.024070332,
0.0041655153,
-0.024672417,
-0.0255101,
0.022630561,
-0.007866378,
0.008265587,
0.029449834,
-0.023546778,
0.0036714126,
-0.002985886,
0.015366269,
-0.012781228,
0.0073166476,
0.030549295,
-0.01220532,
-0.0028517256,
-0.026269251,
0.0276174,
-0.013226247,
-0.0022169182,
0.011334914,
-0.025130525,
0.0069763386,
-0.01890025,
0.008029988,
-0.055548932,
-0.02109917,
0.0037663067,
-0.006361164,
-0.0055758352,
-0.016269397,
0.006884717,
-0.025902765,
0.0139264995,
0.017080903,
0.019751022,
-0.006308809,
0.012840128,
-0.0030578745,
0.0047610565,
0.044004597,
-0.0028386367,
-0.006567313,
-0.003082416,
0.027722111,
-0.024606973,
-0.0153531805,
0.006851995,
0.027774466,
-0.017421214,
-0.006017583,
-0.057800207,
-0.0021891044,
0.0009333961,
-0.00046138073,
0.010130743,
-0.01624322,
0.0066262125,
0.007984177,
-0.01204171,
0.0018651561,
-0.016190864,
0.0026423046,
-0.024358286,
-0.028350374,
-0.02871686,
0.0033343756,
0.040392082,
-0.010111109,
0.01710708,
0.024044154,
-0.0047806897,
-0.020719595,
-0.002072941,
0.022604384,
-0.0036321462,
-0.0027895537,
0.0027093848,
0.0006196736,
-0.0071072266,
0.011393813,
0.014109743,
-0.03612513,
-0.0135861905,
0.003645235,
0.00031740376,
-0.02827184,
-0.032434084,
0.022931604,
0.0035928797,
0.017512836,
-0.027774466,
-0.041386835,
-0.026413228,
0.0014577667,
-0.016766772,
0.004240776,
-0.043481044,
-0.0011452714,
0.011086226,
-0.03400474,
0.049894564,
0.029135702,
0.001942053,
-0.01746048,
-0.023847822,
0.008337575,
-0.015431713,
0.0042833146,
0.005009744,
-0.0333503,
-0.000345422,
0.04041826,
-0.008141243,
-0.0021334768,
0.008972383,
0.0064298804,
-0.014489318,
-0.020850483,
-0.0056445515,
-0.031072848,
-0.009299603,
0.010870261,
0.026884427,
-0.007958,
-0.010529952,
-0.0008385022,
-0.010058754,
-0.005058827,
-0.012048255,
0.007944911,
0.014070476,
-0.00337037,
-0.012107154,
0.032329373,
0.04018266,
-0.020457817,
-0.0065967627,
0.023481334,
0.0006147653,
0.014149009,
-0.0057885284,
0.023913266,
0.017395036,
0.011282559,
0.00706796,
0.003067691,
-0.0007358368,
0.0018766089,
0.014633295,
0.026766626,
-0.0217667,
0.0019796833,
0.00016268989,
-0.022107009,
-0.009921322,
0.042695716,
-0.022879248,
-0.029947208,
0.02683207,
-0.002697932,
0.0135861905,
-0.011197481,
0.020274574,
0.0065444075,
-0.02166199,
0.0012238042,
0.0038808337,
0.0017735345,
-0.012859761,
0.040156484,
0.006079755,
0.017290324,
0.000075567455,
-0.00010603986,
0.027643578,
-0.013560013,
0.019240558,
-0.03005192,
0.01094225,
0.008690974,
0.011262925,
0.004669435,
-0.0435334,
-0.015942177,
-0.018206542,
0.001060194,
-0.018023299,
0.029737787,
0.014711828,
0.080993585,
0.017277235,
-0.027852999,
0.017630635,
-0.026046742,
0.020261485,
0.0025294134,
-0.008998561,
-0.024292842,
-0.014646384,
0.0054482194,
-0.03005192,
0.0023788922,
-0.020052064,
-0.009103271,
0.027277092,
-0.0030840521,
0.011858467,
-0.0039888164,
-0.013455302,
0.021949943,
-0.010909528,
-0.017879322,
0.005461308,
-0.0076962234,
0.012224954,
0.0035110747,
-0.008304853,
0.002923714,
-0.022552028,
0.0066425735,
-0.010372886,
-0.048768926,
-0.009083638,
-0.011675223,
0.0059455945,
-0.018690828,
-0.011262925,
0.030627828,
0.018952604,
0.012388564,
-0.001492125,
0.013278603,
0.0012867942,
0.013121537,
0.013455302,
0.018821716,
-0.0023085398,
-0.0064462414
] |
Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation. However, the molecular mechanisms underlying this process remain poorly understood. Here we identify yes-associated protein (YAP) (homolog of drosophila Yki) and transcriptional coactivator with PDZ-binding motif (TAZ) (also known as Wwtr1), transcriptional effectors of the Hippo pathway, as key matrix stiffness-regulated coordinators of fibroblast activation and matrix synthesis. YAP and TAZ are prominently expressed in fibrotic but | [
-0.03544955,
-0.010765719,
0.009477005,
-0.031537145,
-0.03611043,
0.018914357,
-0.022033706,
0.023064679,
0.009906577,
-0.0072300164,
0.028999371,
-0.025655324,
0.03457719,
0.0233819,
-0.013957765,
-0.01605936,
0.026461596,
0.011142421,
-0.00022717717,
0.0064171352,
-0.022681369,
0.022800326,
-0.013759501,
-0.023897385,
-0.017896604,
0.040340055,
0.011862778,
-0.031907238,
-0.009747965,
-0.023857733,
0.026395507,
-0.0007802503,
-0.007686023,
0.02725465,
0.0057000816,
-0.01513413,
0.0046856324,
-0.020579772,
0.0038165764,
-0.010501368,
0.0032416116,
-0.008155247,
0.001555544,
0.012378264,
-0.009602572,
-0.0185707,
0.01862357,
-0.022456668,
-0.008855779,
0.026818471,
0.018240262,
-0.0079768095,
-0.006096609,
-0.0024931661,
-0.007963592,
-0.0136008905,
0.01299949,
0.031775065,
0.014737602,
-0.010256843,
-0.0072234077,
-0.00063279166,
-0.0185707,
0.0008938389,
0.007930548,
0.0070053176,
-0.0075736735,
0.022483105,
0.0027856051,
0.0012515397,
0.050279677,
0.029475205,
-0.008175073,
-0.0221791,
0.020143593,
0.000961579,
-0.022060141,
-0.008617862,
-0.035105895,
0.030955574,
0.012860706,
-0.0034002226,
-0.0008273379,
0.026144374,
0.021253869,
-0.021967618,
-0.0019942024,
0.015980056,
0.009437352,
-0.009404308,
0.0058619967,
0.031484276,
0.005095377,
0.029369464,
-0.019297667,
-0.0033820483,
0.009371265,
0.006261829,
0.016561627,
-0.029395899,
-0.018821834,
0.024875486,
-0.012444352,
-0.02453183,
-0.02392382,
-0.0025708193,
0.002365947,
-0.0032862208,
0.016707022,
-0.0062552197,
-0.036031123,
0.0209763,
-0.007527412,
-0.046340838,
0.0040247533,
-0.016997809,
0.0318015,
0.0022453365,
-0.012754965,
0.00045435433,
0.034048487,
0.022271624,
0.021253869,
-0.0057397345,
0.025655324,
0.00044733248,
-0.01452612,
0.008948302,
-0.02092343,
0.0033192649,
0.025086967,
0.014724385,
0.021002736,
0.008406381,
-0.046658058,
0.0098008355,
-0.015742138,
-0.021597527,
-0.022773892,
-0.044834033,
0.0128144445,
0.022192318,
-0.03650696,
-0.009199436,
0.007335757,
0.0048111994,
0.018663224,
0.014975519,
0.0012027998,
0.0033374391,
-0.009622399,
-0.009787618,
-0.017288595,
0.004332062,
-0.012100695,
0.020209681,
0.021980837,
0.016759891,
-0.011565383,
-0.020936647,
-0.0038430116,
-0.0012788009,
0.013356365,
0.014975519,
0.008280814,
0.009721531,
-0.0022122925,
-0.021280304,
0.007877678,
-0.0021478569,
-0.013019317,
0.008664124,
-0.030611916,
0.008750038,
0.0035423115,
-0.014248552,
-0.017367901,
0.010574064,
-0.038278114,
-0.026395507,
-0.018028779,
0.000025467076,
0.009576137,
-0.0048905048,
0.0004080928,
-0.030823397,
0.026078286,
-0.020474032,
-0.00049483316,
-0.028972937,
0.0019694194,
0.02812701,
-0.0005237466,
-0.026197243,
-0.6251387,
-0.026025416,
0.026739165,
-0.02157109,
0.002256902,
0.01912584,
0.0035059631,
-0.009774401,
-0.01163808,
0.011115985,
-0.019482713,
0.033837005,
0.0011408424,
-0.009873533,
-0.013944548,
-0.033228997,
-0.0015894141,
-0.03970561,
0.014341075,
0.024214607,
-0.016693804,
0.0154249165,
-0.0049962453,
0.031114183,
0.0023428162,
0.023236506,
0.04113311,
-0.013138275,
0.012094086,
0.05152213,
-0.029184418,
0.041476768,
-0.0016001533,
-0.0001571653,
0.05583106,
0.012715313,
-0.014116376,
0.030241825,
0.016138665,
0.023329029,
-0.015160564,
0.0029706513,
0.02026255,
0.008102377,
-0.025972545,
0.004817808,
0.012206435,
-0.0053729466,
-0.005756256,
-0.017500076,
-0.012827662,
0.00600739,
-0.025404189,
0.015173783,
0.0028715194,
0.020447597,
0.031272795,
-0.009199436,
-0.0016571542,
-0.008294032,
0.021650396,
0.02015681,
-0.023672687,
-0.020685513,
-0.0057893004,
0.016958155,
-0.0021643788,
0.019892458,
0.0072961044,
0.010534411,
0.010256843,
0.017658688,
-0.0027988227,
0.007897505,
0.009728139,
0.040075704,
-0.009701704,
0.014764037,
-0.00035728773,
0.0138123715,
0.008664124,
0.030321129,
-0.021491786,
0.0093778735,
0.012285741,
0.02671273,
-0.023170419,
0.034180664,
0.015861096,
-0.008578209,
0.011188682,
-0.019575236,
-0.024822615,
-0.0491694,
-0.010739284,
0.017737992,
0.0033143084,
0.01354802,
0.01087146,
-0.018041996,
-0.016350146,
-0.020011418,
-0.011400163,
-0.013072187,
0.02343477,
-0.0019743762,
-0.037855152,
0.004057797,
0.02868215,
-0.018227043,
0.0112217255,
-0.012774792,
-0.005068942,
-0.025681758,
0.0044212807,
-0.031669322,
0.04184686,
-0.0045204125,
0.00046137616,
-0.023262942,
0.016892068,
-0.019680977,
0.029871732,
-0.0023015111,
0.030744093,
0.019694194,
0.0038628378,
-0.039309084,
-0.017724775,
0.006668269,
-0.0038198808,
-0.020130375,
0.017328247,
-0.02387095,
0.012160174,
-0.012602963,
0.0046063266,
0.018279914,
0.0066352254,
-0.033202562,
-0.021809008,
-0.017658688,
0.0068136626,
-0.008525339,
-0.019562019,
-0.0267656,
-0.0099924905,
0.0035026588,
0.030030342,
0.012754965,
-0.008227943,
-0.017248942,
-0.004976419,
0.016997809,
0.010745893,
-0.013336538,
0.0072234077,
-0.018398872,
-0.0054456433,
-0.007335757,
0.0106269345,
0.004120581,
-0.007719067,
-0.0050755506,
-0.0008905345,
-0.0062585245,
0.00906726,
-0.010137884,
-0.005237466,
-0.012444352,
-0.0040511885,
-0.007025144,
-0.043961674,
0.0034927456,
0.010256843,
0.013561238,
0.028602844,
-0.01617832,
-0.005614167,
-0.009701704,
0.00282691,
-0.013706631,
0.003018565,
0.0070449705,
0.028708585,
0.020421162,
0.025364537,
-0.0044939774,
-0.0070647965,
0.033625524,
-0.03206585,
0.03959987,
-0.03780228,
0.018478177,
-0.013177928,
-0.018808616,
0.014037071,
0.017777646,
0.0016769805,
0.025496712,
0.011433207,
-0.02015681,
0.032700293,
-0.004358497,
0.0097611835,
-0.021901531,
-0.0028070835,
-0.039203342,
0.019535584,
0.0068004453,
-0.015583527,
0.013865242,
0.010693023,
0.006846707,
0.011314249,
0.012186609,
0.0019198535,
-0.0071176672,
-0.016257623,
0.020170027,
0.0028616062,
-0.010012317,
0.0036183125,
-0.0020421161,
0.002427078,
0.01579501,
0.011175464,
0.05138995,
0.006959056,
-0.012193218,
-0.0018058519,
0.005878519,
0.019905675,
0.013891677,
-0.0014060201,
-0.00028211274,
-0.006030521,
0.0015125868,
0.04237556,
-0.0048211124,
0.009906577,
-0.005667038,
0.008320467,
0.0058355615,
-0.013455497,
-0.011129202,
0.035634596,
0.0051779873,
-0.019680977,
0.0025394277,
-0.0058355615,
0.030294694,
-0.003780228,
-0.00037153793,
-0.0062023494,
-0.0032564814,
0.015147347,
0.023831297,
0.044173155,
0.018782182,
0.006341134,
-0.01644267,
0.004774851,
-0.004573283,
0.0029326507,
-0.016350146,
-0.0010491455,
-0.009007781,
-0.006288264,
-0.008915258,
-0.02109526,
0.008406381,
0.01305236,
-0.025800716,
0.008624471,
0.0047484157,
0.03299108,
0.01687885,
-0.015213435,
0.012424526,
0.0037108357,
-0.05583106,
0.018835053,
0.0042031906,
-0.007315931,
0.014037071,
-0.018121302,
0.015398481,
0.0055315574,
0.01939019,
0.0062089586,
0.00808916,
0.014949083,
-0.007890896,
0.011175464,
0.01490943,
0.018213825,
-0.028100576,
0.031775065,
-0.035713904,
0.0023461205,
0.008201509,
-0.012629398,
-0.007084623,
0.042772092,
0.011578601,
-0.00014921409,
-0.0069061858,
-0.0120081715,
-0.026263332,
0.012384873,
-0.0097810095,
0.008003245,
-0.010025535,
-0.001530761,
-0.007560456,
-0.0024022951,
-0.0022849892,
0.042084776,
-0.015001954,
-0.0015150652,
-0.03309682,
-0.008921866,
0.01966776,
0.03124636,
0.021214217,
-0.009298568,
0.003135871,
0.004692241,
0.02430713,
-0.0046096314,
-0.015861096,
0.011677733,
-0.0050623333,
0.007904113,
-0.017222507,
0.026752383,
0.0077521107,
0.0023196854,
0.01092433,
-0.008221335,
-0.015543874,
0.0009962751,
-0.01628406,
-0.017605817,
0.0061032176,
0.034445014,
0.017050678,
0.023738774,
0.0016612846,
-0.0066914,
0.038145937,
0.008274205,
-0.020117158,
-0.016839197,
0.0313521,
-0.0015547179,
0.008122203,
-0.0026369074,
-0.0054192077,
0.01872931,
-0.006932621,
0.0015695876,
0.014777255,
-0.0025906458,
0.022113012,
0.017116766,
-0.0075472384,
0.0012275828,
0.00237586,
0.008036288,
-0.017817298,
0.0036249214,
-0.017328247,
0.01485656,
-0.026065068,
-0.0067277486,
-0.03211872,
0.009417526,
-0.029580945,
0.009245697,
-0.020896995,
0.014274986,
-0.026633425,
0.0022800327,
0.005158161,
-0.0031903936,
-0.007401845,
0.022958938,
-0.012940011,
-0.025034098,
-0.018768964,
-0.011571991,
0.0027244738,
-0.015385264,
-0.0062519154,
-0.021174563,
0.0042263214,
-0.006033825,
0.015781792,
0.009252306,
-0.0037240533,
-0.009384482,
0.012477396,
-0.0011433207,
-0.021927966,
-0.019443061,
-0.02026255,
0.00022098143,
-0.008353511,
0.008571601,
-0.021491786,
0.006747575,
-0.0027525611,
0.020236116,
-0.0061527835,
0.011922258,
-0.006476614,
0.008617862,
0.0011185377,
0.0267656,
0.020183245,
0.0042626695,
-0.0004568326,
-0.005296945,
-0.020077504,
-0.01070624,
-0.0012184957,
0.003378744,
-0.008776474,
-0.0024898618,
0.00983388,
-0.012305567,
-0.0070053176,
0.0008657515,
0.0118165165,
-0.014697949,
0.009681878,
0.022258405,
0.014565773,
-0.011842952,
-0.0023725557,
-0.0016108926,
0.010355975,
0.005201118,
-0.014037071,
0.036824178,
0.0070647965,
-0.018266696,
0.008564992,
0.0017364597,
-0.004702154,
-0.021399263,
-0.011386946,
-0.01557031,
0.047001716,
0.020249333,
-0.016535193,
-0.0337577,
0.018425306,
-0.01862357,
0.003763706,
-0.0010772328,
-0.010858242,
-0.014605426,
0.020130375,
0.005121812,
-0.017909821,
0.0062420024,
-0.037088532,
-0.017539728,
0.025827153,
0.004764938,
0.0058752145,
0.007917331,
0.008188291,
-0.0024568178,
-0.03222446,
-0.027519003,
-0.035978254,
0.0058586923,
-0.018755747,
0.029422333,
0.04026075,
0.02884076,
0.019839589,
0.019641325,
0.02857641,
0.002793866,
-0.009007781,
-0.017883386,
0.011082941,
-0.014486468,
0.038040195,
0.00083931634,
0.012629398,
0.045812134,
-0.03325543,
0.036586262,
0.017962692,
-0.011770255,
-0.02496801,
0.018755747,
-0.025430625,
-0.02130674,
0.015173783,
-0.0003227981,
0.0030648264,
-0.044781163,
0.020526903,
-0.00311274,
0.013376191,
0.0081486385,
-0.010118058,
0.027651178,
-0.008175073,
0.03248881,
-0.0097810095,
0.027519003,
-0.0037570973,
-0.014037071,
0.00319535,
0.0034530929,
0.021994054,
-0.013065578,
0.016138665,
-0.01665415,
-0.0066120946,
-0.009139957,
-0.0057496475,
-0.019244798,
-0.026514467,
-0.0032217852,
-0.017843733,
-0.0073886276,
-0.021174563,
-0.02469044,
-0.037590798,
-0.0009020999,
0.01846496,
-0.021663614,
0.015226653,
0.0064832233,
-0.016971374,
0.03042687,
-0.006681487,
0.019363755,
-0.011862778,
0.017790863,
0.024782963,
-0.010673196,
-0.0026484726,
-0.0026484726,
-0.011981737,
0.011842952,
0.039573435,
0.0065096584,
-0.022668151,
-0.026316203,
0.013799154,
0.012662442,
-0.015768573,
-0.03359909,
0.004933462,
-0.0036976181,
0.0041635376,
0.012199827,
0.009952838,
-0.014539339,
0.0035026588,
-0.01590075,
0.0136405425,
0.002935955,
-0.0068202713,
-0.0106071085,
0.018028779,
-0.009272133,
0.017500076,
0.001320932,
-0.023844516,
-0.027333956,
-0.008531949,
0.01485656,
0.00070714054,
0.0076728053,
0.025880022,
0.0074481065,
0.016984591,
0.01447325,
0.013296885,
0.014988736,
-0.003839707,
0.003271351,
0.04189973,
0.0029888253,
-0.00058446487,
-0.005277119,
0.00042544087,
-0.0027922138,
-0.009404308,
-0.0011243204,
-0.02610472,
-0.032462377,
-0.0026055155,
0.018861488,
0.0061428705,
-0.0058917366,
0.01579501,
-0.014565773,
-0.016217971,
-0.00018122542,
-0.013733066,
0.008789691,
-0.047398243,
-0.01229235,
-0.00059685635,
0.028153446,
0.0117768645,
0.0026831687,
-0.013838806,
-0.019258015,
0.024346784,
-0.004728589,
0.022020489,
-0.008855779,
0.0036183125,
-0.025628889,
0.017447205,
-0.027571872,
-0.0385689,
0.012953228,
0.0036612698,
-0.030083213,
0.023527293,
0.021809008,
0.03227733,
0.005713299,
-0.013402627,
0.035105895,
-0.0039586653,
-0.0027393436,
-0.013250625,
0.0076661967,
-0.0018256783,
0.0061759143,
0.025417408,
0.0033192649,
-0.014539339,
-0.0010813633,
0.009245697,
-0.013151493,
0.009106913,
-0.006655052,
-0.007177146,
-0.01825348,
-0.0030846528,
-0.010831807,
-0.034127794,
-0.007963592,
-0.013733066,
-0.032911774,
0.017936256,
0.00445102,
-0.012186609,
-0.006413831,
0.021597527,
-0.018174173,
0.018372437,
-0.009311785,
-0.028312057,
0.0027211693,
-0.026527684,
-0.028338492,
-0.0066451384,
-0.03893899,
0.038859688,
0.00029491726,
-0.024333565,
-0.031404972,
-0.0054720785,
-0.056888465,
-0.05408634,
-0.019033317,
-0.0077322847,
-0.010897895,
0.011320857,
-0.011723993,
0.0032878732,
0.011142421,
0.005961129,
-0.0022535974,
-0.032383073,
0.0055183396,
-0.0089945635,
0.022099795,
-0.0016835893,
-0.035370246,
-0.027307522,
0.03201298,
-0.018094867,
-0.011935475,
0.01895401,
-0.020659078,
0.00010904504,
-0.017645469,
0.023408335,
-0.01529274,
0.006261829,
0.029580945,
-0.044648986,
0.015504221,
0.0057166037,
0.013210972,
-0.009120131,
0.0036579655,
0.0097611835,
0.015649615,
0.00439815,
0.014142811,
-0.03587251,
-0.008161856,
-0.015200217,
0.031061314,
-0.0006253568,
-0.0040016226,
0.028920066,
0.032964647,
-0.00483433,
-0.015081259,
-0.0009838836,
-0.0071441024,
-0.00005720734,
0.01572892,
-0.0106071085,
-0.011618253,
-0.0130457515,
0.01436751,
-0.026316203,
-0.007124276,
0.0005402686,
-0.008102377,
-0.012827662,
0.011823125,
0.004517108,
0.0050259847,
-0.028417798,
-0.024333565,
-0.019866023,
-0.01190904,
-0.005528253,
-0.005237466,
-0.0006926838,
-0.0053663375,
0.011400163,
-0.02223197,
-0.0014646731,
-0.0008640993,
-0.004021449,
-0.018980445,
0.022522757,
0.1808165,
-0.007930548,
0.007243234,
-0.019588454,
0.026527684,
0.008439425,
0.019086186,
0.0027343868,
-0.018597135,
-0.010289886,
0.022205535,
0.009721531,
0.027122475,
-0.009358047,
0.002223858,
-0.025985762,
-0.024981227,
0.0163898,
-0.02714891,
-0.008875606,
0.015953619,
-0.018967228,
0.023514075,
0.015768573,
0.041767552,
-0.0076001086,
-0.03560816,
-0.012265915,
0.028999371,
0.009873533,
-0.01475082,
0.0081486385,
-0.008327075,
-0.0006013999,
-0.0066880956,
-0.011466251,
-0.0009830575,
-0.008294032,
0.014327857,
-0.011763646,
-0.012318785,
0.0020949864,
-0.014962301,
0.011122594,
0.0026385596,
-0.020804472,
0.0061825234,
-0.026620207,
-0.008750038,
0.02184866,
-0.04118598,
-0.004626153,
0.03359909,
0.039573435,
0.002015681,
-0.017777646,
0.0016406322,
0.024782963,
-0.006655052,
0.024003126,
-0.0113935545,
0.009510049,
-0.023395117,
0.022668151,
-0.028972937,
-0.0002569167,
0.0045369347,
0.01016432,
0.014341075,
-0.021240652,
0.006347743,
-0.01682598,
-0.0008963172,
0.0036612698,
-0.026131157,
-0.018689658,
0.038542464,
0.008961519,
0.011723993,
0.025853587,
-0.0066980086,
-0.0033176127,
-0.020910213,
-0.005151552,
-0.014882996,
-0.035713904,
0.021399263,
0.0066120946,
-0.016997809,
-0.030638352,
-0.0037042268,
-0.012655833,
-0.01742077,
-0.008353511,
0.00066831394,
-0.009020998,
-0.018068433,
-0.008181682,
-0.021214217,
-0.006985491,
-0.02857641,
0.06529485,
0.01136051,
0.020989517,
-0.017632252,
-0.006767401,
0.0013779327,
0.006499745,
0.005729821,
-0.016204754,
-0.000028268067,
-0.020288985,
0.014010635,
-0.015583527,
-0.011459642,
0.02414852,
0.01332993,
-0.005168074,
0.048217732,
-0.0038925775,
-0.007857852,
-0.03325543,
0.008346902,
0.008075941,
-0.008260988,
0.0062320894,
-0.0033820483,
0.00055679056,
-0.002427078,
-0.03513233,
0.011598427,
0.013468714,
-0.0146582965,
-0.014208899,
0.009933012,
-0.025139838,
0.00013785523,
-0.020236116,
0.004004927,
0.035370246,
-0.012199827,
0.012206435,
0.013627325,
0.030744093,
0.0002936781,
0.008816126,
0.03513233,
0.0005642255,
-0.013799154,
-0.014512903,
-0.019376973,
-0.0063675693,
0.007890896,
-0.014711167,
0.0221791,
-0.012351829,
-0.007560456,
-0.009602572,
-0.006397309,
0.01436751,
-0.03867464,
0.024465742,
0.009258915,
-0.036136866,
-0.0048211124,
-0.017367901,
-0.16537836,
0.013680195,
0.007937157,
-0.01900688,
0.026395507,
0.009510049,
0.01343567,
-0.0057859956,
-0.001179669,
0.0108185895,
0.02884076,
0.008214726,
-0.021491786,
-0.016323712,
-0.0028929978,
0.019799935,
-0.017777646,
0.021888314,
0.0146582965,
0.009814054,
-0.011578601,
-0.011195291,
0.021769354,
-0.018597135,
-0.0038264894,
0.0067541837,
0.024055997,
-0.020103939,
0.00007946038,
-0.0083799455,
-0.0021462047,
-0.014816907,
0.0433801,
-0.009695095,
0.025959328,
0.0030383912,
-0.018782182,
-0.0065757465,
-0.012305567,
0.044490375,
0.025721412,
0.01808165,
0.007930548,
0.011168855,
-0.028153446,
0.043327227,
0.003823185,
0.00148863,
0.013105231,
-0.030241825,
0.020487249,
-0.00061172614,
0.019588454,
0.0289465,
0.020130375,
0.014949083,
0.0163898,
-0.0022453365,
-0.004708763,
-0.017196072,
0.0017166332,
0.005878519,
0.023236506,
-0.0036844006,
-0.008036288,
-0.020315422,
0.0020569859,
0.017407553,
-0.033281866,
0.014552556,
-0.012246088,
-0.0031573495,
0.015689269,
-0.039890658,
0.022192318,
0.0033803962,
-0.009212653,
-0.0066451384,
-0.006275046,
0.012153565,
-0.030717656,
0.0075736735,
-0.0048607653,
-0.040075704,
0.0009607529,
-0.0032498725,
0.010144493,
0.0046096314,
-0.0069788825,
-0.0065460065,
0.0076067173,
-0.0004609631,
0.00065798766,
-0.016680587,
-0.00067285745,
0.011340684,
0.0031474363,
0.017381119,
-0.007771937,
0.0036976181,
0.028523538,
-0.013746284,
-0.011889214,
0.026699513,
0.018597135,
0.016839197,
-0.014949083,
0.01628406,
0.038330983,
-0.020619426,
-0.018240262,
0.009001172,
0.011320857,
0.025020879,
0.0016753284,
0.037379317,
0.019562019,
0.0040941457,
0.029528074,
-0.03402205,
0.07354262,
0.025668541,
-0.0067211394,
0.029157983,
-0.005293641,
-0.017473642,
-0.12160174,
-0.01808165,
0.0056736465,
-0.0015497613,
0.0032151765,
-0.0032350027,
-0.0031226533,
0.03595182,
-0.01672024,
0.02392382,
-0.0064600925,
-0.031669322,
-0.0026567336,
-0.024941575,
-0.00808916,
-0.009966056,
0.005855388,
-0.011631471,
-0.030559046,
0.037590798,
0.008584819,
-0.0077322847,
0.007844634,
-0.010197363,
-0.0051052906,
0.010805372,
-0.02550993,
0.020698732,
0.0010854938,
0.0027806484,
-0.0030450001,
-0.011915648,
0.024095649,
-0.008677342,
-0.005220944,
-0.006020608,
0.0108185895,
-0.024346784,
0.052843887,
-0.017830515,
-0.0053035542,
-0.01349515,
0.0351852,
-0.021888314,
0.009258915,
-0.017936256,
-0.016363364,
0.044067413,
0.024703657,
-0.020632643,
-0.020381508,
-0.008981346,
-0.015609963,
-0.006456788,
0.021319957,
-0.028179882,
0.0045798915,
0.028153446,
-0.008835953,
0.011783473,
-0.007923939,
-0.0076133264,
0.010389018,
0.004441107,
0.033969183,
-0.015081259,
-0.0090143895,
-0.049486622,
0.031563584,
-0.012146956,
0.002567515,
0.008095768,
-0.017500076,
-0.01780408,
-0.0185707,
-0.0031325666,
-0.0058157356,
-0.014116376,
0.00032424377,
-0.0279684,
-0.008683951,
-0.022694586,
0.012669051,
-0.016151883,
0.00595452,
0.0002585689,
0.0040379707,
-0.01682598,
0.02343477,
-0.0073225396,
-0.030030342,
0.034656495,
0.007719067,
-0.0059280847,
-0.016574847,
-0.019046534,
-0.0047550243,
0.0013440627,
-0.003294482,
0.015953619,
-0.045468476,
-0.0152530875,
-0.051363517,
0.007342366,
0.02174292,
-0.0033407435,
0.014129593,
-0.012080869,
0.011109376,
0.0019314189,
0.010580673,
-0.013323321,
-0.031484276,
-0.00015034998,
-0.009946229,
-0.02725465,
-0.0017248943,
-0.018861488,
0.056624115,
-0.011763646,
0.012682268,
0.020183245,
0.013151493,
0.022364145,
0.001663763,
0.004474151,
0.0016084143,
-0.020672295,
-0.039652742,
0.011367119,
-0.0035786598,
-0.004348584,
-0.0047054584,
-0.044093847,
-0.021875095,
-0.001396933,
-0.0048607653,
-0.017539728,
-0.0061098267,
0.023355465,
0.013455497,
0.02272102,
-0.02441287,
-0.014341075,
-0.013772719,
-0.005310163,
0.004441107,
-0.0034101356,
-0.03534381,
0.0012358438,
0.00439815,
-0.010765719,
0.028444232,
-0.0011722342,
0.0065129627,
-0.0061263484,
-0.029898167,
0.00565382,
0.014103158,
-0.034312837,
-0.0065030497,
-0.027492568,
0.0039586653,
0.0061825234,
0.014737602,
0.0014795429,
-0.008056115,
-0.008042898,
-0.011862778,
0.0038628378,
0.010521194,
-0.012332003,
-0.031775065,
0.005032594,
0.0070449705,
0.00808916,
0.017288595,
0.024756528,
-0.031431407,
0.007652979,
-0.016310494,
0.008644298,
0.021769354,
-0.015755355,
-0.031219926,
0.015649615,
0.019826371,
-0.014724385,
-0.027624743,
0.0128540965,
0.0024469045,
0.0055579925,
-0.010256843,
0.0035390072,
-0.002783953,
0.022694586,
0.0030796963,
0.012906968,
-0.0073820185,
0.0037934456,
-0.018108085,
0.030770527,
-0.0017281986,
-0.007183755,
-0.011142421,
-0.009655442,
-0.026725948,
0.023699122,
-0.035793208,
-0.014631862,
0.0065691373,
-0.010197363,
0.015477787,
-0.01048815,
0.010349366,
-0.0118165165,
-0.0038826643,
0.017328247,
-0.01130764,
0.0003002869,
0.0055084266,
0.015583527,
0.01710355,
-0.007937157,
0.009966056,
-0.016455887,
0.016403018,
0.020222899,
0.010051969,
-0.015821444,
0.025602452,
-0.032594554,
0.022245187,
0.0016009795,
-0.03370483,
-0.0061098267,
-0.0015489352,
-0.012477396,
-0.0053960774,
0.023196854,
-0.03862177,
0.09109557,
0.010858242,
-0.0069656647,
0.0077322847,
-0.02054012,
0.003839707,
0.010263451,
0.017936256,
-0.01731503,
-0.049195834,
0.009688486,
-0.008346902,
0.012550092,
-0.019350538,
0.0017116767,
0.012576528,
0.01562318,
0.017989127,
0.014037071,
-0.01354802,
0.012094086,
0.007838025,
-0.0029706513,
0.01070624,
-0.017460424,
0.007970201,
0.05292319,
0.012702094,
0.00565382,
-0.026144374,
-0.014142811,
-0.004599718,
-0.036031123,
-0.005247379,
0.017936256,
-0.00824777,
-0.02430713,
-0.013138275,
0.009106913,
0.020183245,
-0.006565833,
0.015649615,
0.00042461476,
-0.03047974,
0.0031540452,
-0.010930939,
0.01797591,
-0.0034563972,
-0.036850613
] |
LXR alpha is a nuclear receptor that has previously been shown to regulate the metabolic conversion of cholesterol to bile acids. Here we define a role for this transcription factor in the control of cellular cholesterol efflux. We demonstrate that retroviral expression of LXR alpha in NIH 3T3 fibroblasts or RAW264.7 macrophages and/or treatment of these cells with oxysterol ligands of LXR results in 7- to 30-fold induction of the mRNA encoding the putative cholesterol/phospholipid transporter ATP-binding cassette (ABC)A1. In contrast, induction of ABCA1 mRNA in | [
-0.00078395044,
-0.009400676,
-0.006631615,
-0.03450728,
-0.03176177,
0.020685526,
-0.032138605,
0.029097011,
-0.007644358,
-0.011728976,
0.020914318,
0.004104805,
-0.00048281928,
0.02495183,
-0.0050065164,
-0.009696761,
0.026082335,
-0.010524451,
0.01003322,
0.017966934,
-0.0092930095,
0.012442269,
-0.010457159,
-0.016621096,
-0.024359662,
-0.0043436913,
0.013734274,
-0.028181842,
0.004279764,
-0.032246273,
0.02347141,
0.009555448,
-0.0029070096,
0.009057487,
0.012435541,
-0.0061975825,
0.0026765347,
-0.029339261,
0.023000367,
-0.0073078987,
0.03940613,
0.013296876,
0.0061673014,
0.025718959,
0.0071194815,
-0.011580934,
0.012751812,
-0.027589673,
-0.012657603,
0.022744657,
0.008774862,
0.0055515803,
-0.0016789326,
-0.027387798,
-0.0082970895,
0.008310548,
0.006850314,
0.0077654836,
-0.002728686,
-0.0032771148,
-0.011991414,
-0.005837571,
-0.025382498,
-0.00011881223,
-0.0025722324,
0.034049693,
0.007785671,
0.016957555,
0.0048954845,
0.01948773,
0.033188358,
0.007038731,
-0.009212259,
0.019057062,
0.02462883,
0.0041418155,
-0.044816397,
0.00878832,
0.00049291307,
0.002247549,
0.020698983,
0.013438189,
-0.00067754515,
0.020402899,
0.031815603,
-0.01185683,
-0.011957768,
0.01260377,
0.0074021076,
-0.013364169,
0.017590098,
0.0073617324,
0.04164022,
0.022650449,
-0.0025402687,
0.006648438,
0.01915127,
0.004542202,
-0.017442057,
-0.041317217,
-0.005689529,
-0.0078058587,
-0.02414433,
-0.015827052,
-0.025476707,
-0.012240394,
-0.011291578,
0.0034453445,
0.02869326,
0.0025133519,
-0.033188358,
0.02761659,
0.014561964,
-0.041936304,
0.041774802,
-0.018949395,
0.020591317,
0.002333346,
-0.0048214635,
-0.011237745,
0.007819317,
0.032865357,
0.011977956,
-0.0024309193,
0.0124961035,
0.006476844,
-0.004609494,
-0.0049863285,
-0.022179406,
0.0035227302,
0.01781889,
-0.00812213,
0.004451358,
0.014871507,
-0.02628421,
0.004905578,
-0.0153694665,
0.0024191432,
-0.01882827,
-0.029716097,
-0.00063885236,
0.016526887,
-0.0141312955,
0.007112752,
-0.000778483,
0.021358445,
0.034480363,
-0.002644571,
-0.00944778,
0.0010514357,
-0.0030617807,
-0.018276475,
0.02454808,
-0.0018757613,
0.00576355,
0.03741429,
0.008532611,
0.02181603,
0.010430242,
-0.008095214,
0.015557884,
-0.004585942,
0.006574417,
0.01633847,
0.02901626,
0.022125572,
0.017401682,
-0.0053564343,
-0.007664546,
-0.019326229,
0.008774862,
0.015207966,
-0.028020341,
0.034453444,
0.0042932224,
0.012455728,
-0.016217344,
0.009905365,
-0.017845808,
-0.0061067385,
-0.017980391,
0.01966269,
0.03905621,
-0.0077251084,
-0.007536691,
-0.0036640433,
0.016728763,
-0.024373122,
0.008990196,
-0.029716097,
0.00381545,
0.028020341,
0.00039618099,
-0.036041535,
-0.63308203,
-0.011291578,
0.0074357535,
-0.007146398,
0.012341332,
0.018666768,
0.00010593215,
-0.027212838,
-0.0058342065,
0.019958774,
-0.00729444,
0.005316059,
0.028020341,
-0.025543999,
-0.0023030648,
-0.03351136,
-0.010901285,
-0.002661394,
0.04694282,
-0.008990196,
-0.007032002,
-0.0154233,
-0.019070521,
0.013384356,
0.009541989,
0.028343342,
0.023955911,
-0.024265453,
0.009602552,
0.0068065743,
-0.005083902,
0.04104805,
0.0066046985,
0.0012827516,
0.050576583,
-0.0067291884,
-0.003418428,
0.009743865,
0.03940613,
0.034103528,
-0.02271774,
-0.0028245768,
0.02430583,
0.012644146,
-0.030200599,
0.00978424,
0.020847026,
0.04220547,
0.0046902443,
-0.00023783476,
-0.0032973024,
-0.0009092816,
-0.017953476,
-0.008027922,
0.0031374842,
0.0041249925,
0.019891482,
-0.026324585,
0.0033477712,
0.014790757,
-0.0100197615,
0.019124353,
-0.030335182,
-0.008882529,
-0.019030144,
0.01633847,
0.00056525186,
0.021762196,
-0.0001527736,
0.0018875374,
0.005423726,
0.023175325,
0.007698192,
0.012617229,
0.0018555737,
0.0038625542,
0.0077251084,
0.02405012,
-0.007637629,
0.028854761,
-0.010060137,
0.011601121,
-0.0053429757,
-0.0053530694,
0.03442653,
0.009232447,
-0.025086414,
-0.0016116407,
0.019339688,
-0.00042120516,
0.011459808,
-0.0024578362,
-0.010908015,
-0.037764207,
-0.019205105,
0.034103528,
-0.018478353,
0.011237745,
0.010833994,
-0.02454808,
-0.011850101,
-0.009582365,
0.0153694665,
-0.007556879,
0.02711863,
-0.003953398,
-0.031331103,
-0.010840722,
0.029743014,
-0.046377566,
-0.010073596,
-0.0017462245,
-0.018626394,
-0.01078016,
-0.006924335,
-0.017038306,
0.014494672,
0.0014795803,
-0.0039668567,
-0.04993058,
0.041747887,
-0.0058173835,
0.027078254,
-0.004727255,
0.007953901,
0.01608276,
-0.0020052982,
-0.020389441,
-0.008424944,
0.0008554481,
0.007247336,
0.014400464,
0.019555021,
-0.023727119,
0.02637842,
0.012630687,
0.021869862,
0.005127642,
-0.018478353,
-0.02861251,
-0.025772791,
-0.0052117566,
0.007974088,
-0.013074813,
-0.011069515,
-0.013996712,
0.013438189,
0.0152483415,
-0.01567901,
0.010107242,
-0.026243836,
-0.0027236391,
-0.013808295,
0.03380744,
0.014225504,
-0.007529962,
-0.0023939088,
-0.0050435266,
-0.0077318377,
0.010968577,
0.0012549936,
0.016648013,
0.0048450157,
0.0073751905,
0.0017966933,
-0.0059586964,
0.02695713,
0.029877597,
-0.035610866,
-0.037602704,
0.0075097745,
-0.005696258,
-0.034776445,
-0.012314415,
0.0017563183,
0.019043604,
0.0038692835,
-0.0066450736,
0.014804215,
-0.021210402,
0.012213477,
0.014212046,
-0.01384867,
-0.0150060905,
0.0135862315,
0.012879667,
0.023108033,
0.018518727,
0.014104379,
0.013915962,
-0.022004446,
0.023565618,
0.002563821,
0.013633336,
0.008263444,
-0.01781889,
0.012967146,
0.0014964032,
0.027374338,
0.008088484,
0.019581938,
-0.021129653,
0.02255624,
-0.019770356,
0.017603558,
-0.0042494824,
0.0028144831,
0.007745296,
0.0017714589,
-0.00035538527,
0.0010430242,
-0.0039197523,
0.002316523,
-0.005877946,
0.003956763,
0.012004873,
0.0068267616,
0.00588804,
0.01865331,
-0.053456675,
-0.007422295,
-0.0061639366,
0.013290147,
0.008270172,
-0.0013298559,
-0.006833491,
0.00862682,
0.01210581,
-0.015759759,
-0.0032030938,
-0.009171884,
-0.017199805,
0.006046176,
0.009541989,
0.007752025,
0.0008672242,
0.006285062,
-0.010854181,
0.011890477,
-0.009198801,
0.0108070765,
-0.003973586,
0.008290361,
0.025772791,
0.0003074398,
-0.004279764,
0.018666768,
0.015705926,
-0.0052050273,
-0.005420361,
0.010847452,
0.028020341,
-0.010477346,
0.008505695,
-0.0028985979,
0.0152483415,
0.011251203,
0.0153694665,
0.0310081,
-0.0015275258,
0.017522806,
0.012771999,
-0.017953476,
-0.00060436525,
-0.0051545585,
0.008330735,
-0.015705926,
0.0012583582,
-0.009676573,
0.0031744947,
-0.02869326,
-0.008027922,
0.01227404,
-0.028208759,
0.022529323,
0.007025273,
0.007025273,
-0.007913526,
0.03383436,
-0.00267317,
-0.007220419,
-0.026997505,
0.035503197,
0.0068301265,
-0.01900323,
-0.027132088,
-0.014427381,
0.0022509135,
-0.0037178767,
0.010187992,
0.011116619,
-0.009965928,
0.021183485,
-0.001602388,
-0.027751174,
-0.016944097,
0.035045613,
-0.03989063,
0.016217344,
-0.024897998,
0.019057062,
-0.00019924706,
0.010087053,
-0.0069041476,
0.04462798,
-0.0045489315,
0.0009160108,
-0.0057601854,
0.01418513,
-0.01592126,
-0.00026159722,
-0.004942589,
-0.0012549936,
-0.027751174,
0.013741003,
0.00094124523,
-0.02295999,
0.007146398,
0.022744657,
-0.014575423,
-0.021990988,
-0.028074175,
0.001986793,
0.009851532,
0.009945741,
0.00064474036,
0.0055583096,
0.019676147,
-0.0068200324,
0.0063086143,
-0.012267311,
-0.020793192,
0.012334603,
0.0082970895,
0.014548506,
0.007745296,
-0.0039029294,
0.005151194,
0.0026395242,
0.012119269,
-0.009669844,
-0.04460106,
0.011453079,
-0.012805645,
0.0082365265,
-0.005827477,
0.025113331,
0.03531478,
0.007388649,
-0.008431673,
0.0021634342,
0.02064515,
0.010746514,
-0.023673285,
-0.0016225756,
0.0054270905,
0.007839505,
0.005854394,
0.008963279,
-0.019043604,
-0.002223997,
0.004104805,
-0.011042599,
0.0019346417,
-0.0042091073,
0.01916473,
0.019043604,
-0.005383351,
0.010127429,
-0.0074088364,
-0.013915962,
0.0055414867,
0.008855612,
-0.01260377,
0.0062177703,
-0.018599477,
-0.019851105,
-0.012758542,
-0.031546436,
-0.010504263,
0.013061355,
0.0027959778,
0.013236314,
-0.021829488,
-0.008357652,
-0.015625175,
0.0067796577,
-0.0057029873,
0.02355216,
-0.0027959778,
-0.0031391664,
-0.0358262,
-0.002134835,
0.016782597,
0.007180044,
-0.028154925,
-0.0038356374,
0.013162293,
0.0070118145,
0.018209184,
0.009158426,
-0.024063578,
0.025678584,
0.031061934,
-0.022610074,
0.0020709077,
0.0019312771,
-0.022865783,
0.0061067385,
-0.0014635985,
0.018559102,
-0.03657987,
0.0030331817,
0.006322073,
0.005093996,
-0.011883747,
0.024238538,
-0.011796268,
-0.012980605,
0.0033965579,
0.020268315,
0.023457952,
0.013875587,
-0.013693899,
-0.0097169485,
-0.013747732,
0.0014392053,
-0.013169022,
-0.00970349,
-0.016405761,
0.01458888,
0.01078016,
-0.028101092,
-0.010490805,
0.007852963,
0.007879879,
-0.009266092,
-0.0129335,
-0.0011019047,
0.034884114,
-0.008283631,
0.03714512,
-0.000057250676,
-0.010685951,
0.009434322,
-0.011338683,
0.016634554,
0.0057097166,
-0.015746301,
0.014979173,
-0.011459808,
0.005824113,
-0.015625175,
0.008034651,
0.007603983,
0.011183911,
-0.012738354,
-0.038033374,
-0.03558395,
0.0067931158,
-0.017697766,
-0.005215121,
0.009441052,
-0.020806652,
-0.013794837,
0.027293589,
0.002247549,
-0.0076712747,
0.009629468,
-0.02613617,
-0.010120699,
0.007819317,
-0.004585942,
-0.005329517,
0.0017765057,
-0.0074693994,
-0.018949395,
-0.03092735,
-0.01849181,
-0.031438768,
-0.006103374,
-0.013458377,
0.026472628,
0.019891482,
0.03267694,
0.0013727545,
0.0021953979,
0.017132513,
-0.0011330271,
0.010093783,
0.01119737,
0.029581513,
-0.027535839,
-0.002372039,
0.012812375,
-0.008667195,
0.020752817,
-0.031223435,
0.02917776,
0.024494246,
-0.015329092,
-0.003216552,
0.012401895,
0.004303316,
-0.035476282,
-0.007738567,
-0.010396596,
-0.0073953783,
-0.018357227,
-0.025409415,
0.0356647,
0.0030903798,
0.014790757,
0.0029255147,
0.019864565,
-0.02985068,
0.022125572,
0.0015510779,
-0.00853934,
0.0045489315,
-0.016944097,
0.00928628,
-0.004612859,
-0.0048551094,
-0.011836642,
0.014696548,
0.024911456,
-0.017899642,
0.022690823,
-0.0005274002,
-0.00026348978,
-0.0032451511,
-0.011432892,
0.0039197523,
-0.005349705,
-0.022636991,
0.009185342,
-0.055663846,
-0.01458888,
0.02944693,
-0.0014265879,
0.034291945,
-0.0054304553,
-0.008936362,
0.024521163,
-0.0020759546,
0.031142684,
-0.042609222,
0.030146765,
0.020833567,
0.0025587738,
-0.034372695,
-0.017845808,
0.008068297,
-0.010066866,
0.036041535,
0.019178187,
-0.007166586,
0.008754674,
-0.007859692,
0.013808295,
-0.02960843,
-0.029420013,
-0.008068297,
-0.012630687,
-0.009723677,
-0.00038650777,
-0.020160649,
-0.031196518,
0.009333384,
-0.014212046,
0.006833491,
-0.0022357728,
0.0063725417,
-0.005255496,
0.025826626,
0.009555448,
-0.013633336,
0.0014148119,
-0.019676147,
0.014117838,
-0.021035444,
-0.008162506,
0.0061269263,
-0.011399246,
0.01757664,
0.010510992,
0.016190428,
0.010060137,
0.035422448,
0.0068435846,
-0.019797273,
-0.008007734,
0.042555388,
-0.013471835,
0.001981746,
0.024426954,
0.018464893,
0.0053026006,
-0.008821966,
-0.010908015,
-0.020604776,
-0.032650024,
0.020847026,
0.019528106,
0.002893551,
-0.035287865,
0.0037548873,
-0.019783814,
0.00729444,
-0.03830254,
-0.012825834,
0.008768133,
-0.04645832,
-0.015948176,
-0.011574204,
0.0071396693,
0.016486512,
0.0027707433,
0.0034890843,
-0.01857256,
0.021937154,
-0.04470873,
0.02480379,
0.00059174804,
0.012489374,
-0.02363291,
0.013175751,
-0.014615797,
-0.024400037,
0.02032215,
-0.026230376,
-0.036418367,
-0.04303989,
-0.025745876,
0.0017361307,
0.023202242,
0.008680653,
0.015396384,
-0.010376409,
0.015934719,
-0.00068175094,
0.0038289083,
0.00870757,
-0.01824956,
0.027831923,
0.017267099,
0.008835425,
0.00048618388,
-0.013471835,
-0.009844803,
0.00464314,
0.0043975245,
0.0028111185,
0.000118286516,
0.024521163,
-0.018155351,
-0.0011254568,
0.00037704484,
-0.0021196944,
-0.012125998,
0.0106253885,
0.016553804,
-0.0069377935,
-0.025113331,
0.0055448515,
0.01625772,
0.0018522091,
-0.016715305,
0.0073617324,
0.00032951994,
-0.0129335,
-0.008552799,
0.0072136903,
-0.022381281,
0.028827844,
-0.007280982,
-0.03125035,
-0.014871507,
-0.015719384,
-0.029823763,
-0.026270753,
-0.012597041,
0.022529323,
-0.03563778,
-0.0011885429,
0.0047979113,
0.0023451222,
0.0030735568,
0.0027084984,
0.0024982113,
-0.026661046,
0.020241398,
-0.027091714,
0.02917776,
0.0072675236,
-0.03905621,
-0.026216919,
0.03351136,
-0.0042763995,
-0.014319713,
0.028504843,
-0.026486086,
0.013956337,
-0.0073953783,
0.018289935,
0.0035126365,
-0.0031122498,
0.028720176,
-0.04368589,
0.012442269,
0.031465687,
0.0015939765,
0.0017361307,
0.0019733345,
-0.00018421153,
0.018478353,
-0.004760901,
0.0005757662,
-0.022085197,
0.017226722,
-0.0005669341,
0.011015682,
0.022623532,
0.01301425,
0.004377337,
0.016365387,
-0.015557884,
0.017886182,
-0.014198588,
-0.016674928,
-0.005437184,
0.01102914,
0.011641496,
-0.007637629,
-0.015853968,
-0.021129653,
-0.02596121,
0.041021135,
-0.00017716692,
-0.016526887,
-0.019797273,
0.015813593,
-0.0008281108,
-0.009999574,
-0.019353146,
-0.0015435077,
-0.010295658,
-0.013902503,
0.0062312284,
0.009003654,
-0.026714878,
-0.0031660832,
0.004649869,
-0.015140674,
-0.022785032,
0.008404757,
-0.026836004,
0.001783235,
0.015342549,
0.18120359,
-0.027172463,
-0.010847452,
0.01161458,
-0.016432678,
0.0004971188,
0.0012020014,
0.016405761,
-0.01484459,
0.036364533,
0.020806652,
0.025395958,
-0.02430583,
-0.0030752392,
-0.00006366443,
0.012946959,
-0.029339261,
-0.0052117566,
-0.00081381126,
-0.006052905,
0.006675355,
0.0019598762,
0.015880885,
-0.024278913,
0.048853908,
0.010161075,
-0.040375132,
0.0115001835,
0.014615797,
-0.008761403,
-0.012967146,
-0.010309117,
-0.0021735278,
0.004966141,
0.012758542,
0.005090631,
-0.013384356,
0.0018606207,
0.001636034,
-0.012146185,
0.0026580296,
-0.0074761286,
-0.027966507,
-0.031223435,
0.0001447827,
-0.0001293266,
-0.013821754,
-0.013707357,
-0.0056155077,
0.008411486,
-0.04586615,
0.003509272,
0.00030828096,
0.02613617,
-0.008357652,
-0.029150845,
0.008344194,
0.026163084,
0.025934292,
0.045704648,
0.011049327,
0.012967146,
-0.025059499,
0.025288291,
-0.010786889,
0.03962146,
0.0026866286,
-0.017966934,
0.020833567,
-0.022583157,
0.0057097166,
0.014898423,
-0.029904515,
-0.012004873,
-0.0035395531,
-0.021627612,
0.020026065,
0.026714878,
0.024911456,
0.02678217,
0.0060327174,
-0.015329092,
-0.03714512,
0.011836642,
-0.0048080054,
-0.027428173,
0.015598259,
0.021129653,
-0.01874752,
-0.010181262,
0.012819104,
-0.021344986,
-0.020281775,
-0.0022223145,
0.009138238,
-0.01767085,
-0.003839002,
-0.012745083,
-0.021842945,
-0.0088421535,
-0.040025212,
0.08042726,
-0.0037010538,
0.015625175,
0.0016671565,
0.0012348061,
-0.020026065,
0.0023955912,
-0.0043268683,
-0.0057770084,
0.009918824,
-0.019420438,
0.0022845594,
-0.011601121,
-0.014387005,
0.007220419,
0.016957555,
-0.037602704,
0.033861276,
0.0034436623,
-0.018814811,
-0.008492236,
0.011264661,
-0.002876728,
0.00037178767,
-0.026593752,
-0.024507705,
-0.027993424,
-0.013243043,
-0.031815603,
-0.019783814,
0.003805356,
-0.005894769,
0.013377626,
-0.009743865,
-0.019137813,
0.023094576,
-0.0066450736,
-0.013794837,
0.025005665,
-0.012146185,
0.0019884752,
0.028397176,
-0.013969796,
0.009912095,
-0.024400037,
0.0036640433,
0.0052857776,
-0.025907377,
0.0085999025,
-0.021681445,
0.0016007057,
-0.008546069,
0.010975307,
0.018532185,
-0.011345412,
-0.015073382,
-0.028101092,
0.02604196,
0.0055280286,
-0.00837784,
0.0060226237,
0.02952768,
-0.03765654,
-0.007738567,
-0.0031492603,
-0.17032921,
0.000058985544,
0.002984395,
-0.015975093,
0.006120197,
0.019447355,
0.0018522091,
-0.0026984047,
-0.027966507,
0.003674137,
0.020214483,
0.003748158,
-0.04212472,
-0.02993143,
0.004626317,
-0.014064004,
-0.015113758,
0.016284637,
0.004760901,
0.0015527603,
0.039998297,
-0.016594179,
0.007826046,
-0.012839292,
0.012152915,
0.021923697,
0.00936703,
-0.0014047181,
-0.014777298,
-0.01741514,
-0.0023198877,
0.017791975,
0.02869326,
-0.007280982,
0.03962146,
0.017038306,
-0.009764053,
-0.0097169485,
-0.0057770084,
0.024669206,
0.010585014,
0.039379213,
-0.01890902,
0.0069445227,
-0.029393096,
0.022125572,
-0.008350923,
-0.011782809,
0.02123732,
0.0054304553,
0.0019834284,
-0.022838866,
0.009844803,
0.019689607,
0.035207115,
0.024736498,
0.0018606207,
0.038840875,
-0.0106253885,
-0.0015031325,
-0.02371366,
-0.005225215,
0.033242192,
-0.0115271,
0.02122386,
-0.02189678,
-0.008990196,
-0.010739785,
-0.024776872,
0.0074828574,
-0.026432253,
-0.018155351,
-0.003906294,
-0.0057971957,
0.033888195,
0.015046465,
-0.029204678,
0.0058914046,
0.02297345,
0.005272319,
-0.009245905,
0.0076510874,
-0.027428173,
-0.0088421535,
-0.018801352,
0.012327873,
0.013317064,
0.011486725,
-0.005790467,
-0.0030819683,
0.03308069,
-0.023457952,
-0.0061403844,
-0.008808508,
0.0065340423,
0.018505268,
0.0047709947,
-0.0008722711,
-0.009905365,
-0.0035193656,
0.041828636,
-0.017024847,
-0.0021163297,
-0.011446349,
0.022758115,
-0.011479995,
-0.037333537,
0.011311766,
0.06320054,
-0.026930213,
-0.0043235035,
-0.01392942,
0.0016528569,
0.027670423,
0.0057097166,
-0.0067190947,
0.007166586,
-0.01857256,
0.0068805953,
-0.021035444,
0.048369408,
0.007590525,
0.019945314,
0.02057786,
0.0042023784,
-0.022704283,
-0.1214484,
-0.03526095,
-0.004609494,
0.0134651065,
-0.0130411675,
0.035772365,
-0.0054775593,
0.010376409,
-0.008855612,
0.028827844,
-0.010733056,
0.0033393598,
-0.007603983,
-0.0063456246,
0.01767085,
0.007832776,
0.020806652,
0.004905578,
-0.020093357,
0.036875952,
0.002627748,
-0.026499545,
0.0026126076,
0.013034438,
0.015813593,
-0.011897205,
-0.01384867,
0.011728976,
0.008189422,
0.0022963355,
0.0099591995,
-0.0057601854,
0.016769137,
-0.016069302,
-0.011298307,
-0.04371281,
0.019972231,
0.004205743,
0.02022794,
-0.014306255,
0.021412278,
-0.0015956588,
-0.00439416,
-0.017724684,
-0.008734487,
-0.007146398,
-0.022825407,
0.0046801507,
0.0018168809,
-0.00015203761,
-0.028639426,
-0.026755253,
-0.03423811,
-0.014656173,
0.024642289,
-0.026889838,
0.016150052,
0.02901626,
-0.03558395,
-0.018155351,
0.016930638,
0.0045893067,
-0.015719384,
-0.0030163587,
0.0012028425,
-0.019312771,
0.0012306004,
-0.028854761,
0.012987334,
-0.016742222,
-0.008189422,
0.009003654,
-0.012832562,
0.017886182,
-0.023404118,
0.022515865,
-0.021089276,
-0.006675355,
0.01161458,
-0.027387798,
-0.0097169485,
-0.025422875,
0.00039849413,
-0.011325224,
0.008593174,
0.013256501,
0.002242502,
-0.001336585,
0.009737136,
-0.025557458,
-0.022704283,
0.04742732,
0.006493667,
-0.015450217,
-0.004757536,
-0.013243043,
0.007846233,
-0.009642927,
0.016190428,
-0.0043066805,
-0.011412703,
-0.015100299,
-0.063900374,
0.014440838,
0.010154345,
-0.02297345,
0.00878832,
-0.023767494,
0.01119737,
-0.020510567,
-0.00017958521,
-0.0053126942,
-0.020524025,
0.015800135,
0.0016713622,
-0.0011162042,
-0.0013391086,
-0.020672068,
0.051087998,
-0.011823184,
0.01956848,
0.028800927,
0.033888195,
0.016822971,
0.006931064,
-0.013081542,
-0.019393522,
-0.0076578166,
0.0016276225,
0.015705926,
-0.021735279,
-0.008512423,
-0.0140101705,
-0.033376776,
-0.008357652,
0.00995247,
-0.01649997,
-0.0043335976,
-0.008680653,
0.012428811,
0.01956848,
0.021748737,
0.0027825194,
-0.03439961,
0.0009092816,
0.0152618,
0.001732766,
-0.01715943,
-0.04212472,
0.007994276,
0.00944778,
-0.0055684033,
0.017240182,
0.01924548,
-0.007826046,
-0.019137813,
-0.0069445227,
-0.0031997291,
0.0020406265,
-0.034588028,
-0.006668626,
-0.02985068,
0.006005801,
0.04360514,
0.0060394467,
-0.0113184955,
0.003916388,
-0.024696123,
-0.015867427,
0.00244606,
0.028451009,
-0.047534987,
-0.035718534,
0.012745083,
-0.005733269,
0.005225215,
-0.0035866576,
0.00075619254,
-0.022704283,
-0.01301425,
-0.01326996,
0.016594179,
0.0040274193,
-0.016580721,
-0.01351894,
-0.0014400464,
0.013155564,
0.0031088851,
-0.0072338777,
0.0052958713,
0.0067729284,
0.018101517,
-0.011567475,
0.013243043,
0.006369177,
0.008525882,
-0.0028885042,
-0.0086604655,
0.016540345,
0.0066551673,
-0.014521589,
0.031384934,
0.0001841064,
0.0026630764,
-0.0030886976,
-0.030577432,
-0.008680653,
0.013505481,
-0.022085197,
-0.043147556,
-0.013478565,
-0.027145546,
0.003980315,
0.0056861644,
-0.0046465048,
0.010275471,
-0.020079898,
0.00033246397,
-0.00070824707,
0.0062480518,
0.009999574,
0.012509561,
0.017899642,
0.024830706,
0.0081759645,
0.011560746,
0.006375906,
0.009306468,
0.044816397,
-0.018047683,
0.020268315,
-0.017778516,
0.008290361,
0.009340114,
-0.040913466,
-0.028128007,
0.002123059,
0.003391511,
0.007106023,
0.0008764768,
-0.04320139,
0.085972115,
0.01865331,
-0.031896353,
0.0018017403,
0.010827265,
0.049876746,
0.005168017,
0.010632118,
-0.016567262,
-0.013155564,
0.032300103,
-0.021035444,
0.013310335,
-0.04818099,
-0.024063578,
0.01924548,
-0.0018135163,
0.0076309,
-0.0004300372,
-0.02379441,
-0.011540558,
-0.0031559893,
0.005696258,
-0.0049392246,
-0.033780526,
0.005231944,
0.04196322,
0.0018252924,
-0.0008647007,
-0.0071867732,
-0.005332882,
0.0015477134,
-0.028235676,
-0.004908943,
0.010006303,
-0.022650449,
-0.020537483,
0.0042023784,
0.027562756,
0.027831923,
0.007516504,
0.019729981,
0.005877946,
-0.033484444,
0.013249773,
-0.02653992,
-0.01707868,
0.012152915,
-0.041344136
] |
Synchronous oscillations of thousands of cellular clocks in the suprachiasmatic nucleus (SCN), the circadian centre, are coordinated by precisely timed cell-cell communication, the principle of which is largely unknown. Here we show that the amount of RGS16 (regulator of G protein signalling 16), a protein known to inactivate Gαi, increases at a selective circadian time to allow time-dependent activation of intracellular cyclic AMP signalling in the SCN. Gene ablation of Rgs16 leads to the loss of circadian production of cAMP and as a result lengthens circadian period of behavioural rhythm. The tempor | [
-0.0117382,
0.010975625,
0.016150238,
-0.0145297665,
-0.01902351,
0.015156168,
-0.017362187,
0.0011013073,
-0.017661769,
0.006611248,
0.011608834,
-0.005920165,
-0.0027881628,
0.011145842,
0.0007642766,
0.010233477,
0.031347256,
0.0019779275,
0.002798376,
0.021828694,
-0.011724582,
0.009634311,
-0.0035915894,
-0.021610815,
0.017634533,
0.008007032,
0.0041090506,
-0.01943203,
-0.011554365,
-0.012589287,
0.00513376,
-0.0026128388,
-0.009130468,
0.006812105,
0.020072049,
-0.024375148,
0.0038537243,
-0.018383492,
0.012432687,
-0.008422363,
0.021883164,
0.012262469,
-0.015728097,
0.00489886,
-0.014802115,
0.019690761,
0.026594784,
-0.017838795,
0.004432464,
0.025764123,
-0.008095545,
0.0067780614,
-0.033280928,
-0.018111143,
-0.00943005,
-0.006400178,
0.023027025,
0.02169252,
0.0062401737,
-0.020739302,
0.011077755,
-0.013311009,
-0.034016266,
0.01713069,
0.018465195,
0.00039937283,
-0.01508808,
-0.010233477,
-0.012745887,
-0.0070265788,
0.053570855,
0.023367459,
-0.024919843,
0.014951906,
0.009518563,
-0.027275654,
-0.028623777,
0.0166677,
-0.00048043893,
0.0020392057,
0.006192513,
-0.01954097,
-0.0074214833,
0.022441477,
0.006781466,
0.009184937,
-0.0139714535,
0.023639807,
-0.011064138,
0.018506048,
0.045345943,
0.02049419,
0.009716015,
0.003761807,
-0.027602471,
-0.0014221673,
0.01016539,
0.013385905,
-0.031102143,
-0.010199433,
-0.002168571,
0.006086978,
-0.007836814,
-0.01451615,
-0.024252592,
-0.014339123,
0.016245559,
-0.011261591,
0.0049056686,
-0.018315405,
-0.025845828,
0.03867342,
0.004286077,
-0.02761609,
-0.0029890195,
-0.007850432,
0.020358015,
0.025532627,
-0.008681093,
-0.02609094,
0.01393741,
0.008013841,
0.01723963,
-0.023081494,
0.020630362,
0.012105869,
-0.0041567115,
0.00024575152,
-0.02084824,
-0.019813318,
-0.021733372,
-0.0008055544,
-0.01042412,
0.028460369,
-0.02049419,
0.008252145,
0.0015302554,
0.0050895037,
-0.020426102,
-0.004200968,
0.003703933,
0.024756435,
-0.027997376,
0.014570619,
0.015183402,
0.033253692,
0.015442133,
0.024388764,
-0.0009796018,
0.012664183,
0.046271928,
0.0041873506,
-0.00033362632,
-0.013903366,
0.0090623805,
0.016259177,
-0.009763677,
0.045128066,
-0.0013966346,
-0.026622018,
0.01011092,
-0.013372287,
0.020031197,
0.008667476,
0.033417102,
0.016858343,
0.005726117,
0.0054095127,
0.0014732325,
0.012058209,
-0.016041297,
0.012875252,
-0.024143651,
0.036794215,
-0.010036024,
0.040933907,
-0.0027183737,
0.008973867,
-0.009886233,
-0.0091440845,
-0.04164201,
-0.000142238,
0.010151773,
0.0166677,
-0.015537455,
-0.013998688,
0.022618502,
0.008388319,
0.014856584,
-0.005416321,
-0.0060767652,
-0.009668355,
-0.00979772,
-0.014693175,
-0.62618256,
-0.017062603,
-0.01860137,
-0.011799478,
0.02231892,
0.024810905,
0.010076877,
0.014339123,
-0.015197019,
0.018900953,
-0.027779497,
0.0031183849,
0.010832642,
-0.024007477,
-0.027411828,
-0.04322163,
0.00037639347,
0.0009217278,
0.02268659,
0.0045141685,
-0.014379975,
-0.0020970798,
0.005620582,
0.024252592,
0.017539212,
0.011363721,
0.022441477,
-0.024252592,
-0.018451579,
0.034615435,
-0.026662871,
0.009014719,
-0.014271036,
-0.0038026592,
0.05558623,
-0.014134862,
-0.027234802,
0.029685933,
-0.007680214,
0.03823766,
-0.029522525,
-0.014570619,
0.027738646,
-0.000001896662,
-0.030829795,
0.011452234,
0.001642599,
-0.017825177,
0.007918519,
-0.0457,
0.016463438,
-0.0050486512,
-0.016245559,
0.010396886,
0.02090271,
-0.009913468,
0.01162926,
-0.004517573,
-0.002013673,
0.006846148,
0.003431585,
0.019867787,
-0.013719532,
-0.016613228,
-0.0021804862,
0.023980243,
-0.013596974,
0.007142327,
0.0071219006,
0.0127118435,
0.016245559,
0.02645861,
-0.0068495525,
0.020085666,
-0.0064886915,
0.0154829845,
0.00557973,
0.017348569,
-0.015128932,
0.02237339,
0.0010340713,
-0.014162097,
-0.017185159,
-0.004861412,
0.018614987,
-0.0026570954,
-0.005773778,
0.0066725262,
-0.0024273016,
-0.020140136,
-0.0027966737,
-0.003285198,
0.011193504,
-0.011193504,
-0.015128932,
0.03976281,
0.0023472994,
0.0116769215,
0.011908417,
-0.021556346,
-0.016599612,
0.0027473106,
-0.00838151,
-0.015019993,
0.020480571,
-0.00838151,
-0.032246005,
-0.009518563,
0.0370938,
-0.018628605,
0.011670113,
-0.00013628039,
0.0077823447,
-0.007142327,
-0.016749403,
-0.02001758,
0.03840107,
0.02782035,
0.018628605,
-0.021978484,
-0.009396006,
-0.01639535,
-0.00040426658,
-0.010710086,
0.026131792,
0.0172941,
-0.0028307172,
-0.019758848,
-0.00974325,
-0.0050486512,
0.0027881628,
-0.031674076,
0.017729856,
-0.016272794,
0.019350326,
0.014189332,
0.04338504,
-0.010812216,
0.013876132,
-0.03698486,
-0.03159237,
0.01566001,
0.009021528,
-0.004888647,
0.009913468,
-0.00260603,
-0.037584025,
0.004939712,
0.00505546,
0.00044511879,
0.022931702,
-0.0138148535,
0.0005663988,
0.010131346,
0.010873495,
-0.012126296,
-0.028378664,
-0.013719532,
-0.017784325,
0.0025311343,
0.025369218,
0.003160939,
-0.0057976083,
-0.01676302,
-0.033716686,
-0.007659788,
-0.019186918,
-0.00045831065,
-0.008299806,
-0.023966625,
-0.019241387,
-0.005862291,
-0.0074214833,
0.029468056,
0.0109688165,
0.0070742397,
-0.017171543,
0.0034758416,
0.0018468599,
-0.011969695,
-0.0050146077,
-0.0019387774,
-0.03426138,
-0.014842967,
0.02818802,
0.021175059,
0.02132485,
0.0060903826,
0.0025038996,
0.010308373,
-0.02053504,
0.016436202,
-0.027725028,
0.01770262,
-0.00069746625,
-0.036058877,
0.016912812,
0.0039150026,
0.01801582,
0.027670559,
0.026322436,
-0.035704825,
0.012977383,
-0.02152911,
0.0104922075,
-0.013018236,
0.00838151,
-0.0038843637,
0.0024290038,
0.016735785,
-0.005831652,
0.028841656,
0.010070068,
-0.012807165,
0.0037107416,
0.010247095,
-0.014965524,
0.013787618,
0.0022077211,
-0.0102539025,
-0.00526653,
-0.0070606223,
0.019731613,
-0.0073942486,
-0.011370529,
0.03415244,
0.013174836,
0.023803217,
0.0015574902,
0.0045618294,
-0.029822107,
0.016381733,
-0.026867133,
0.022536797,
0.015387663,
0.028106315,
-0.021896781,
-0.015551072,
0.037039332,
0.016327264,
0.008824076,
-0.0018774992,
0.033144753,
-0.013542505,
-0.008258954,
-0.005845269,
0.016899195,
0.002857952,
-0.024334295,
0.019935874,
-0.025341982,
0.016068533,
-0.045972344,
0.00900791,
0.016517907,
0.002032397,
0.0137399575,
0.007884475,
0.018070292,
0.020752918,
-0.012371409,
0.02489261,
0.009293876,
-0.025587097,
-0.034751605,
0.020521423,
0.027357358,
-0.010281137,
-0.019323092,
-0.0058350563,
-0.00055490906,
0.022781912,
-0.00083661906,
-0.041996066,
0.033226456,
-0.01058072,
0.012970574,
0.002994126,
0.021624433,
0.011213929,
-0.008265763,
-0.010955199,
0.0028443346,
0.007162753,
-0.0056716474,
-0.011656495,
-0.028977828,
0.0050520557,
-0.0028307172,
0.0044767205,
-0.020657597,
0.010315181,
-0.020712066,
-0.010185815,
0.00083534245,
-0.009178128,
0.034751605,
0.0007885326,
0.0030673195,
-0.0066214614,
-0.00505546,
0.025723271,
0.011465851,
-0.01409401,
0.039272584,
0.0056307954,
-0.00071789237,
-0.004657151,
0.012282896,
-0.018369874,
0.016340882,
-0.0135016525,
0.003031574,
-0.033144753,
-0.00006590609,
0.013038661,
0.0061210217,
-0.0012817378,
0.020630362,
0.00044256554,
-0.020126518,
-0.021855928,
-0.0076461704,
-0.034370318,
0.020712066,
0.018437961,
-0.011486278,
0.017988587,
-0.002731991,
-0.008211292,
-0.02592753,
-0.026485845,
0.018506048,
-0.0069244485,
-0.016463438,
-0.010410503,
-0.008041075,
0.005307382,
-0.0008498109,
0.016844725,
-0.0033192413,
-0.0062946435,
-0.0013166325,
0.020167371,
0.016422585,
0.013522079,
0.007298927,
0.048423477,
0.0075372313,
-0.022986172,
0.013644636,
0.008681093,
0.0070810486,
-0.033825625,
-0.021365702,
0.008790032,
-0.006999344,
0.007339779,
0.012480347,
-0.034533728,
0.011220738,
0.006648696,
-0.010226668,
0.011465851,
0.02614541,
0.0169809,
0.015959594,
-0.01860137,
-0.0013234412,
-0.021665284,
-0.014175714,
0.02163805,
-0.019867787,
0.0070265788,
0.021365702,
-0.0115816,
0.012180765,
-0.008497258,
0.01650429,
-0.008653859,
-0.0008106609,
0.0036596765,
-0.004064794,
-0.012092252,
-0.015019993,
-0.015374046,
0.01105052,
-0.0071287095,
-0.012480347,
0.004003516,
0.01939118,
-0.034669902,
-0.026962453,
0.00014042945,
0.008721945,
-0.03856448,
-0.018151995,
0.0017770708,
0.027793115,
0.026254348,
0.025968384,
0.0009634311,
-0.010124537,
0.016531525,
-0.022863615,
-0.023612574,
-0.006502309,
-0.017062603,
-0.0068699787,
0.01372634,
0.043357804,
0.00036703152,
-0.00027873117,
-0.0016102577,
0.019445648,
0.008681093,
0.051283132,
-0.01309994,
-0.0023200647,
0.0043439507,
0.020480571,
0.0044528903,
0.004919286,
0.002263893,
0.0039762813,
-0.0047116205,
-0.018696692,
-0.009879424,
-0.00009484307,
0.0028358237,
0.018111143,
0.008265763,
-0.022087425,
-0.0012842912,
0.014979141,
-0.029331882,
-0.0006234216,
0.008898972,
-0.010042833,
0.0073874397,
-0.00037639347,
0.03148343,
0.0029192304,
-0.012623331,
-0.010076877,
-0.0015796185,
0.005518452,
-0.009355155,
-0.026431374,
0.008735563,
0.0023404907,
0.004432464,
-0.02436153,
-0.009709206,
-0.019445648,
0.04254076,
-0.014393592,
-0.04651704,
-0.0063150697,
-0.007687023,
-0.008252145,
0.01707622,
-0.020739302,
-0.0023575125,
-0.010723704,
0.0025328365,
-0.0017140904,
-0.0033277522,
0.0154829845,
-0.03777467,
-0.00020787814,
-0.031156613,
0.0047116205,
0.0093823895,
0.006485287,
-0.005103121,
-0.01639535,
-0.01545575,
0.0020494189,
-0.047660902,
-0.0067235916,
-0.020044815,
0.032137066,
0.028651012,
0.02393939,
-0.01100286,
-0.0132633485,
0.034125205,
0.014951906,
-0.0033192413,
-0.016749403,
0.009110041,
-0.043357804,
0.011166269,
-0.008483641,
-0.0046877903,
0.011765434,
0.0039218115,
0.007149135,
0.01619109,
0.015442133,
-0.022291685,
-0.000011143928,
-0.025682418,
-0.028106315,
0.024770051,
-0.016041297,
-0.014216566,
-0.028324194,
-0.026431374,
0.034642667,
0.007571275,
0.0046707685,
-0.03132002,
0.03221877,
-0.034370318,
0.027071392,
-0.017947733,
0.031183848,
-0.020480571,
-0.022073807,
-0.010825833,
0.010294755,
0.019609056,
0.0022128276,
0.006066552,
-0.00544696,
-0.019186918,
0.0044596987,
-0.013842088,
-0.014202949,
-0.0121535305,
-0.011057329,
-0.017117074,
-0.01954097,
-0.012262469,
-0.01939118,
-0.034179676,
0.008013841,
0.021011649,
-0.026009236,
0.024878992,
-0.010301564,
-0.014025923,
0.033716686,
-0.0057771825,
0.029876577,
-0.011036904,
0.017797943,
0.0150063755,
0.0030281695,
-0.008395128,
-0.022877233,
-0.0023353843,
0.00013894004,
0.02393939,
0.0027779497,
-0.01429827,
-0.017525595,
-0.0031354066,
0.02651308,
-0.019609056,
-0.03551418,
0.008980676,
0.014148479,
0.00035000977,
-0.015687246,
-0.01954097,
-0.0039933026,
0.003237537,
-0.006308261,
-0.012528009,
-0.010757747,
0.0034571176,
-0.022182746,
0.012187574,
-0.008585772,
0.01639535,
0.010485399,
-0.001962608,
-0.0044971467,
-0.0010289649,
-0.0071899877,
0.0051303557,
-0.011860756,
0.026880749,
-0.0013549314,
-0.016885577,
0.0019915449,
0.00017691983,
0.014230184,
-0.015700864,
-0.013699105,
0.039354287,
-0.020426102,
-0.03194642,
0.017661769,
0.014734028,
-0.0005553346,
-0.001896223,
-0.009675163,
0.006720187,
-0.019472884,
-0.000874918,
0.020358015,
0.014557001,
-0.0031932804,
-0.010437738,
-0.016422585,
-0.018192848,
-0.0383466,
0.0029737,
0.018002205,
-0.04997586,
0.012909296,
-0.0043439507,
0.01939118,
0.026349671,
0.009402815,
-0.01440721,
0.012214809,
0.017770708,
-0.025001548,
0.010444546,
0.011574791,
-0.0019609057,
-0.008190867,
0.0051643993,
-0.0040579853,
-0.050683964,
0.026050087,
-0.024742818,
-0.03398903,
0.005647817,
0.0034741394,
0.019813318,
0.006144852,
-0.012725461,
0.0069040223,
0.0194865,
0.00969559,
0.018397108,
-0.024470469,
-0.01304547,
-0.0038775548,
0.0023660234,
0.016545141,
-0.02163805,
0.009818146,
0.0015489793,
-0.010185815,
0.010369651,
-0.010682851,
0.0013072705,
-0.0055524954,
0.013562932,
-0.011969695,
-0.0061857044,
-0.008864928,
-0.010281137,
-0.027044158,
0.029141238,
-0.00050512044,
-0.014815732,
-0.03510566,
-0.021283997,
-0.0025141127,
0.028678246,
-0.013276965,
0.018574135,
0.015918741,
-0.035160128,
-0.035350773,
-0.0022434667,
-0.020385249,
0.025369218,
0.02053504,
-0.025151338,
-0.013365479,
-0.012541627,
-0.02818802,
-0.019445648,
0.010641999,
0.009763677,
-0.00075278693,
0.021569964,
0.007993414,
0.007727875,
-0.006308261,
0.023176815,
0.0020851644,
-0.0005276743,
0.0051235473,
0.0017336654,
0.009184937,
-0.0010059855,
-0.021297615,
0.020657597,
0.04207777,
-0.012991,
-0.016899195,
0.00911685,
0.0026043279,
0.020684833,
-0.0084359795,
-0.0040852204,
-0.0176073,
0.0182337,
0.013923792,
-0.018723926,
0.010226668,
0.0044052294,
0.0057125,
-0.025178574,
0.02200572,
-0.005239295,
0.0069584916,
0.011745009,
-0.02090271,
-0.029794874,
0.026308818,
-0.0049805646,
0.03254559,
0.020671215,
0.0025600714,
-0.004551616,
0.016436202,
-0.01860137,
-0.02393939,
-0.0017872838,
-0.0084291715,
0.006781466,
-0.0040171333,
-0.0077074487,
0.0026128388,
0.0037788288,
0.024960695,
-0.02152911,
0.008367892,
-0.007047005,
-0.00060257,
-0.030993205,
0.02949529,
0.021774223,
-0.020072049,
-0.0063491133,
-0.016953664,
-0.015305959,
-0.01801582,
-0.001740474,
-0.007367014,
-0.023353843,
-0.005852078,
0.013018236,
0.0055048345,
0.005239295,
-0.023204051,
0.008286188,
-0.0185469,
0.0023285756,
0.18247317,
0.015128932,
-0.0029583804,
0.010390077,
0.005957613,
-0.0005234188,
0.012289704,
0.003577972,
-0.007516805,
0.019214153,
-0.0024749625,
0.010151773,
-0.0054844082,
-0.0008153419,
-0.0049907775,
-0.02112059,
-0.014815732,
0.000083247,
-0.0132633485,
-0.013637827,
0.031510666,
-0.021106971,
-0.014557001,
-0.008619815,
0.025151338,
-0.0079525625,
-0.02178784,
-0.019472884,
0.014693175,
0.030884266,
-0.02944082,
0.023803217,
-0.0040307506,
0.00025468794,
-0.005082695,
0.019895023,
-0.0051678037,
-0.012160339,
0.0026366692,
0.0077551096,
-0.0037652114,
-0.0022894256,
-0.003353285,
0.000039309605,
0.023367459,
0.009804528,
0.0021055907,
-0.017539212,
-0.011636069,
0.003897981,
-0.056702856,
0.013481227,
0.035623122,
0.036603574,
0.0075099966,
-0.01928224,
0.020562274,
0.028514838,
-0.014870201,
0.021678902,
-0.029086769,
0.007584892,
-0.023067877,
0.018519666,
0.00013457822,
0.04082497,
-0.01911883,
0.022359772,
0.032191537,
-0.010866686,
-0.0045379987,
0.00070512603,
-0.018002205,
-0.009355155,
-0.0050077992,
-0.008892163,
0.023694277,
0.0247292,
0.013052279,
0.035541415,
-0.010117729,
0.016218325,
-0.04254076,
-0.0011047117,
-0.0025192192,
-0.013365479,
0.034397554,
0.012636948,
-0.026962453,
-0.0063729435,
0.007898092,
0.0064886915,
-0.017321333,
-0.0029124217,
-0.002022184,
-0.040525384,
0.006124426,
-0.0057499474,
0.008075119,
-0.026472228,
-0.0037515939,
0.063729435,
0.0032886022,
0.020140136,
-0.008000223,
-0.014761263,
0.0021209102,
0.016599612,
0.003829894,
-0.015265106,
0.005276743,
-0.015169784,
0.021569964,
0.00015957892,
0.00565803,
0.023558103,
0.029250177,
-0.019581823,
0.044692308,
-0.020262692,
-0.01053306,
-0.012779931,
-0.00529036,
0.029005064,
-0.01608215,
-0.009327919,
-0.0071763704,
-0.0022145298,
0.000054682376,
-0.028950594,
0.019418413,
-0.0012579074,
0.014080392,
0.00029766787,
0.02436153,
-0.033444338,
0.016163854,
-0.0059031434,
0.008388319,
0.0042145858,
-0.0004646938,
0.0051780166,
0.014747645,
0.022114659,
0.009668355,
-0.01738942,
0.010900729,
0.023054259,
-0.037584025,
-0.0008893865,
0.0043030987,
-0.026907984,
0.029195707,
-0.01100286,
0.01964991,
-0.023027025,
-0.04431102,
-0.05150101,
0.014230184,
0.015687246,
-0.014897437,
-0.012793548,
0.021447407,
-0.008327041,
-0.0008106609,
0.018751161,
-0.17288652,
0.0042247986,
0.026172644,
-0.035350773,
-0.003227324,
0.009504946,
0.0012076932,
0.0106488075,
-0.01639535,
0.014393592,
0.02724842,
0.008728754,
-0.039381523,
-0.018792013,
0.008292997,
0.0012127998,
-0.040361974,
0.014502532,
0.0054775993,
0.018533282,
0.012316939,
-0.024524938,
0.020671215,
-0.003390733,
0.0019353731,
0.009259833,
0.015510219,
-0.009927086,
-0.014175714,
-0.02195125,
-0.026172644,
0.023844069,
0.01047859,
0.0033175393,
0.02530113,
-0.02058951,
-0.028923359,
-0.00995432,
-0.007530423,
0.009287068,
0.016354498,
0.01954097,
-0.0015574902,
0.032055363,
-0.027738646,
0.022427859,
0.0024851756,
-0.017212395,
0.0017566447,
-0.021134205,
0.014284654,
0.000257454,
0.011949269,
0.012997809,
0.0066997614,
0.040144097,
0.004619703,
0.005327808,
-0.0038775548,
-0.009212172,
0.008544919,
-0.0135016525,
0.026472228,
-0.0069244485,
0.004245225,
-0.005395895,
-0.0066827396,
-0.0012502476,
-0.011595217,
0.026608402,
-0.008837693,
-0.0130250435,
-0.00069661514,
-0.048423477,
0.028732715,
0.0020766535,
0.0057090954,
0.006485287,
0.0031268958,
0.010914347,
0.005035034,
0.010962008,
-0.026390523,
-0.015864272,
-0.003996707,
-0.026336053,
0.012528009,
0.038591713,
0.0064410307,
-0.00061703846,
0.027057776,
-0.002451132,
0.015605541,
-0.012255661,
0.03725721,
-0.003547333,
-0.00030745537,
-0.0072785006,
0.0048103468,
-0.017566446,
0.01608215,
-0.00604953,
-0.0049805646,
0.029359115,
0.016177472,
-0.0025498583,
-0.0050758864,
-0.016245559,
0.03368945,
-0.013903366,
-0.00911685,
-0.014557001,
0.00071831787,
0.031156613,
-0.014475297,
0.030693622,
0.009450477,
-0.015197019,
0.011193504,
-0.028896125,
0.06552693,
0.021052502,
-0.014202949,
0.009239406,
-0.0061210217,
-0.02609094,
-0.12876615,
-0.023775982,
0.014202949,
0.03540524,
-0.010853069,
0.01707622,
-0.0035303112,
0.0065465653,
-0.0150063755,
0.0377202,
-0.009307493,
-0.018315405,
0.007115092,
0.004892051,
0.009048763,
-0.0032562609,
0.01472041,
-0.043248866,
0.0013438673,
0.037529558,
0.010458164,
0.0032681762,
-0.009150893,
-0.0005957613,
-0.005753352,
-0.006406987,
-0.03137449,
0.015891507,
0.02116144,
0.010962008,
-0.002206019,
-0.010655616,
0.007475953,
0.001914947,
-0.038727887,
-0.018900953,
-0.02022184,
-0.04333057,
0.036766984,
-0.019404797,
0.0033686045,
0.0149246715,
0.027479915,
0.011070947,
-0.0037277634,
0.00056937756,
-0.0005774629,
0.012085443,
0.019009892,
-0.015918741,
-0.009416433,
-0.008980676,
-0.019323092,
-0.020262692,
0.033907328,
-0.009375581,
-0.0051371646,
0.03107491,
-0.006590822,
-0.0059269737,
0.006189109,
0.0075985095,
-0.015687246,
-0.002457941,
0.0021089949,
-0.025083253,
-0.031891953,
-0.027847584,
0.031265553,
0.0005966124,
-0.010941582,
0.02530113,
-0.025600713,
-0.005269934,
-0.03992622,
0.015374046,
-0.0063354955,
-0.012813974,
-0.0041873506,
0.015945977,
-0.01713069,
-0.022414241,
0.035759296,
-0.008776415,
-0.0047797076,
-0.007155944,
0.017062603,
0.0022962342,
-0.011813095,
-0.009021528,
-0.0144480625,
0.01933671,
-0.002663904,
-0.00880365,
-0.011261591,
0.016204707,
-0.019377561,
0.003314135,
-0.0030673195,
0.009600268,
-0.028514838,
-0.020712066,
-0.0587727,
0.011506704,
0.012180765,
-0.0018553708,
0.002897102,
-0.021869546,
0.009511755,
-0.010410503,
0.009784102,
-0.0035847807,
-0.0136582535,
-0.014979141,
-0.015292341,
-0.016681315,
-0.022713825,
-0.032082595,
0.030012751,
-0.017430274,
0.029195707,
0.018696692,
-0.015442133,
0.008184058,
0.008980676,
0.02509687,
0.004783112,
0.0023949603,
-0.0038469157,
0.018247318,
-0.013787618,
0.0018996274,
0.017811561,
-0.040144097,
-0.017212395,
-0.0022672971,
-0.0038945766,
-0.037584025,
0.0042145858,
0.04537318,
0.019363943,
0.01911883,
-0.016163854,
-0.010444546,
0.013957836,
-0.000943005,
0.015197019,
0.0078095794,
-0.048450712,
-0.0115203215,
0.006447839,
-0.022700207,
0.005463982,
0.019976728,
-0.00032213665,
-0.015374046,
0.003761807,
-0.01608215,
-0.012221618,
-0.018097525,
-0.0053822775,
-0.014761263,
0.017021751,
0.033934563,
0.015251489,
-0.007428292,
0.010376459,
-0.009600268,
-0.048123896,
-0.0072853095,
0.009525372,
-0.018301787,
-0.044855718,
0.012841209,
0.044501666,
0.008844502,
-0.009722824,
-0.0044869334,
-0.0004125647,
-0.011928843,
-0.021719754,
0.016531525,
0.016940046,
0.009647928,
-0.011288825,
0.0125212,
0.005198443,
0.002536241,
-0.0054980256,
0.019255005,
0.009613885,
0.007884475,
0.0050520557,
0.011595217,
0.02215551,
-0.012139913,
0.022237215,
0.035269067,
-0.020943562,
0.0025821996,
0.0011991824,
0.023135964,
0.0013915282,
0.011670113,
-0.0018213274,
-0.02294532,
0.011404573,
0.04049815,
-0.024238974,
-0.036086112,
-0.021828694,
-0.017103456,
-0.0077414922,
0.0062878346,
0.028732715,
0.008395128,
-0.008054692,
0.0028936977,
0.0024936865,
0.0024170887,
-0.02027631,
0.0077210665,
0.0033396676,
-0.0067474223,
-0.0013115259,
-0.003246048,
-0.012228426,
-0.014488914,
0.02095718,
-0.035160128,
0.028705481,
-0.016204707,
0.025750505,
-0.0052324864,
-0.031156613,
-0.017048987,
-0.014393592,
-0.022073807,
-0.001351527,
0.015442133,
-0.043793563,
0.08976591,
0.009634311,
-0.002110697,
0.023612574,
-0.027602471,
0.019445648,
-0.015619159,
0.028514838,
-0.049730748,
-0.034806076,
0.0030162544,
-0.012296513,
0.0241028,
-0.025110487,
-0.013154409,
0.029876577,
0.015646394,
0.022182746,
0.0063933698,
-0.018138377,
0.031510666,
-0.016300028,
-0.004503955,
0.0052631255,
-0.006366135,
-0.02116144,
0.033090282,
0.005065673,
0.0075099966,
-0.039790045,
0.012657374,
-0.013862514,
-0.038155958,
0.008824076,
-0.008109163,
0.0029992326,
-0.00989985,
-0.032872405,
0.012861636,
0.030829795,
-0.02289085,
0.009559415,
-0.015959594,
0.008252145,
0.005705691,
-0.0037515939,
-0.022972556,
0.004987373,
-0.018873718
] |
Human TopBP1 is a major player in the control of the DNA replication checkpoint. In this study, we identified MDC1, a key checkpoint protein involved in the cellular response to DNA double-strand breaks, as a TopBP1-associated protein. The specific TopBP1-MDC1 interaction is mediated by the fifth BRCT domain of TopBP1 and the Ser-Asp-Thr (SDT) repeats of MDC1. In addition, we demonstrated that TopBP1 accumulation at stalled replication forks is promoted by the H2AX/MDC1 signaling cascade. Moreover, MDC1 is important for ATR-dependent | [
-0.031662602,
0.0021491598,
-0.01763828,
-0.045066614,
-0.017975403,
0.030691685,
-0.015291903,
0.03864779,
-0.0043724864,
0.007153752,
0.014792961,
0.017112369,
0.016492061,
0.016842669,
-0.0008280586,
0.0009768142,
0.018096767,
-0.013997351,
-0.030772595,
-0.0005221194,
-0.028776826,
0.008616867,
-0.013343331,
-0.017624795,
0.0139434105,
0.0011141918,
-0.006061473,
-0.039295066,
-0.011192487,
-0.012567949,
0.017422521,
-0.008090954,
0.008333683,
-0.0072211768,
0.010814909,
-0.0073560257,
0.0026666436,
-0.010053011,
0.027280001,
-0.025203323,
0.0115970345,
0.019620564,
0.002643045,
-0.0004374172,
-0.00966869,
-0.009007929,
0.029208343,
-0.018433891,
-0.011974612,
-0.00048461443,
-0.014819931,
-0.005110786,
-0.011435215,
-0.0021339892,
-0.01947223,
-0.017004488,
0.015170539,
0.026336055,
0.0015709936,
-0.018204646,
0.00025431722,
-0.017948434,
-0.01856874,
0.009028156,
0.0046287,
0.012082491,
0.01837995,
0.0003270094,
0.0069919326,
0.02114436,
0.040913258,
0.019081166,
0.0004816646,
-0.0022233268,
0.017193278,
-0.04037386,
-0.032201998,
0.0017698962,
-0.009163005,
0.026754089,
0.018865408,
0.016181909,
0.016667366,
0.011785823,
0.015332358,
-0.0077336035,
-0.013619773,
-0.017840553,
0.0042376374,
-0.005589501,
0.020146476,
0.02180512,
0.021481482,
0.011792566,
-0.033253822,
0.0024188582,
0.005582758,
0.017071914,
-0.01514357,
-0.021980425,
-0.019175561,
-0.0077875433,
-0.00026632723,
-0.012304992,
-0.02651136,
0.002300865,
0.009540583,
-0.01607403,
0.008192091,
0.006004162,
-0.025108928,
0.01057218,
-0.025769688,
-0.027671063,
0.0076122396,
-0.010484528,
0.0048849136,
-0.0019401434,
-0.0066649234,
0.009527098,
0.027077727,
0.057014257,
0.0145772025,
-0.011226199,
0.022614216,
0.0021457884,
-0.0080504995,
-0.004149985,
0.030988354,
0.021575877,
0.018771013,
0.030395018,
-0.0000052807172,
0.001205215,
-0.01405129,
0.016087513,
-0.01689661,
-0.031311993,
-0.037946574,
-0.029531982,
0.0117655955,
0.030556837,
-0.0023699752,
-0.014374929,
0.0056973803,
0.013026436,
0.0032616658,
0.011347563,
-0.009682175,
0.0073088286,
-0.023558162,
0.00081541645,
0.013457954,
-0.010882333,
-0.017422521,
0.022465883,
-0.00972263,
0.005333287,
-0.007241404,
-0.027778942,
0.026268631,
0.008900049,
0.030421987,
-0.019741928,
0.009581038,
0.03743415,
-0.020456629,
0.01010695,
0.0047399504,
-0.01668085,
-0.0044904794,
0.00920346,
-0.04414964,
0.009614751,
-0.03573505,
0.011664459,
-0.00503999,
0.015440238,
-0.017368581,
-0.012965754,
-0.004278092,
0.0057580625,
0.026174236,
0.009702402,
-0.02026784,
-0.008583154,
0.018878892,
-0.021441028,
-0.0046792687,
-0.020604962,
0.00977657,
0.018838437,
0.0016856154,
-0.0013392215,
-0.61275494,
-0.017206762,
-0.011893703,
-0.015399783,
0.015386297,
0.027199091,
0.039780524,
0.019162076,
-0.01670782,
0.011071122,
0.0024829116,
0.005677153,
-0.0079493625,
-0.02834531,
-0.04563298,
-0.03344261,
-0.023558162,
-0.0011302051,
0.021508453,
-0.0065604155,
-0.051296648,
0.0036780129,
-0.013761365,
0.026915908,
-0.010403618,
-0.022492852,
0.03711051,
-0.009014672,
0.0078010284,
0.02579666,
-0.018649649,
-0.0028790312,
0.00753133,
-0.014199625,
0.048249055,
-0.004959081,
0.0026666436,
0.0238818,
0.019350866,
0.026443936,
0.009608008,
0.0066480674,
0.030934414,
-0.0049085123,
-0.0010231686,
0.019647533,
-0.008266258,
0.004075818,
-0.009985586,
-0.0012136431,
0.006088443,
0.008367395,
-0.022290578,
-0.006031132,
0.0046657836,
0.027617123,
0.022465883,
-0.03708354,
0.023436798,
0.0019957686,
-0.002015996,
0.028857736,
-0.0029464557,
-0.026079843,
-0.0075380723,
-0.003116703,
-0.009493386,
0.010208087,
0.0221827,
-0.016465092,
0.018420406,
-0.005316431,
0.019189047,
-0.009270885,
0.009115809,
0.020577993,
-0.0022334405,
0.015224479,
0.008090954,
0.04058962,
0.015655996,
-0.013289392,
-0.020025112,
-0.018096767,
0.020645417,
0.014091745,
-0.03155472,
0.025607869,
-0.00062494195,
-0.012689313,
0.009567553,
-0.020753298,
0.007430193,
-0.008347168,
-0.009216946,
0.018784499,
-0.014172655,
-0.015763875,
0.0017901236,
-0.015467207,
0.009843994,
-0.007052615,
-0.012399388,
-0.0058153733,
0.034224737,
-0.0028722887,
-0.011219457,
0.0054141968,
0.032768365,
-0.009817025,
-0.01109135,
0.012878102,
-0.0015111542,
0.011610519,
0.008960731,
-0.015588571,
0.015237964,
0.018137222,
-0.011307108,
-0.007369511,
0.009136036,
-0.010086723,
-0.0020935345,
-0.02456953,
0.015332358,
0.023490736,
0.01944526,
-0.014347958,
-0.0027357538,
-0.016047059,
-0.010936273,
-0.005070331,
0.029639862,
-0.025351657,
0.032013208,
0.0030964755,
0.0053231735,
0.0015280104,
0.0057209786,
-0.03711051,
-0.03028714,
-0.010990213,
0.005474879,
0.0069110235,
-0.016316757,
-0.033065032,
-0.02643045,
0.00027601953,
0.00966869,
0.009479901,
0.026120298,
-0.001980598,
0.020456629,
0.0026464162,
0.007173979,
-0.013215225,
0.0052186656,
-0.026039388,
-0.0106598325,
-0.020591479,
-0.011104834,
0.0062131784,
-0.012473554,
-0.031258054,
0.010916046,
-0.009601265,
0.018137222,
0.006412081,
-0.010673317,
-0.027576668,
0.002823406,
-0.028749857,
-0.039942343,
0.0024913396,
0.0018794612,
0.023261493,
0.004429797,
0.008778685,
-0.009823767,
-0.004348888,
-0.0092574,
0.0015389669,
0.004726466,
-0.033011094,
0.03743415,
0.018245101,
0.038971428,
-0.01678873,
0.013741137,
0.025378626,
-0.018555256,
0.024448166,
-0.0048242314,
0.0141322,
0.013060149,
0.009533841,
0.009351795,
0.02273558,
-0.004247751,
0.019714959,
0.02454256,
-0.0017151138,
0.009479901,
-0.024124527,
0.0026228176,
-0.030907445,
-0.012588176,
-0.025729233,
0.0024154868,
-0.022344518,
-0.011981355,
-0.011880218,
-0.0041129016,
-0.0028992586,
0.0034689966,
0.01415917,
-0.004959081,
-0.00030446428,
-0.029316224,
-0.012048779,
0.002393574,
0.017813584,
0.011185744,
-0.02231755,
-0.0020530797,
-0.0028250916,
0.01585827,
0.04231569,
-0.0009869279,
0.015103115,
-0.0018019229,
0.0019822838,
0.0077875433,
-0.008825882,
-0.0008841053,
0.022641188,
0.008461789,
0.011340821,
0.03503383,
-0.007072842,
-0.0049388534,
-0.0025368512,
-0.0145772025,
-0.020281324,
0.010147405,
-0.0077403462,
0.012224083,
-0.0012894958,
-0.0041129016,
0.017854039,
-0.006924508,
-0.0015221108,
-0.021778151,
-0.0012515695,
0.008401107,
-0.01580433,
-0.004045477,
0.022290578,
0.027536213,
0.0068705687,
0.007167237,
-0.007578527,
0.021508453,
-0.019903747,
0.015925694,
-0.012945526,
0.004072447,
0.003940969,
-0.016613426,
-0.0131478,
0.0073425407,
0.020200415,
0.01657297,
-0.03503383,
0.011947642,
0.0020227386,
-0.018245101,
0.022344518,
-0.0017125853,
-0.008252773,
-0.013464696,
-0.04913906,
0.014226594,
0.032633513,
-0.01402432,
-0.0035735047,
-0.023558162,
-0.0034369698,
-0.01668085,
0.0024879684,
-0.013060149,
0.013498409,
-0.013525378,
0.011185744,
-0.015210994,
-0.015278419,
0.00843482,
-0.016195394,
0.010605892,
-0.0050737024,
0.011057638,
0.016883124,
0.0001922655,
-0.012190371,
0.035708077,
0.0011622319,
-0.0054007117,
-0.010875591,
-0.018609194,
-0.03740718,
0.012089234,
-0.0019131735,
-0.010100207,
-0.0055153337,
0.008832625,
0.01506266,
0.0026919278,
-0.0033189768,
0.020834208,
0.009742857,
-0.034872014,
-0.016532516,
-0.006894167,
-0.014064775,
0.029882591,
0.034386557,
-0.024893168,
0.011219457,
-0.0063446565,
0.030664716,
-0.0058288584,
-0.026443936,
0.03716445,
-0.026066357,
-0.007605497,
-0.008643836,
-0.014320989,
0.007929135,
0.0048242314,
0.03212109,
0.013849016,
-0.03190533,
0.0049118833,
-0.00319087,
-0.0045882454,
-0.013107345,
0.029370163,
0.039996285,
0.03230988,
-0.0062671183,
-0.011462185,
0.029046526,
0.01142173,
-0.019714959,
0.010288997,
0.015305388,
-0.001832264,
0.030341078,
0.004335403,
-0.024218922,
0.0138085615,
0.013619773,
0.019404804,
0.027266515,
0.008724745,
-0.012723025,
0.012210598,
0.009169748,
0.010154148,
0.003913999,
0.024218922,
0.009796797,
-0.009075354,
-0.024461651,
0.018339496,
-0.016006604,
-0.021238755,
-0.017881008,
-0.011549837,
-0.02555393,
0.0221827,
-0.022668157,
-0.010538468,
-0.016006604,
-0.027617123,
-0.026336055,
-0.0012397702,
0.0048141177,
-0.00397131,
-0.00041908614,
-0.01224431,
-0.043394484,
0.00006463282,
-0.0062704897,
-0.017813584,
-0.019539654,
-0.026133781,
0.012122946,
0.018177677,
0.023234524,
0.02223664,
-0.008805655,
-0.010524983,
0.02831834,
-0.024191953,
-0.011704913,
0.011812793,
-0.023221038,
-0.009540583,
0.024690894,
0.024272863,
-0.017759643,
-0.029046526,
0.023868315,
-0.0077605736,
-0.0012085863,
0.028911676,
-0.013383786,
-0.0037724073,
0.02709121,
0.01361303,
0.039834466,
0.0074436776,
0.012675828,
-0.005444538,
-0.033928066,
-0.020497084,
-0.024299832,
0.019863293,
-0.0066514383,
-0.0055557885,
0.0023210924,
-0.017921463,
-0.010484528,
0.01840692,
-0.011320594,
-0.0019789126,
-0.007362768,
0.017516915,
0.032013208,
0.00016919365,
0.029154405,
-0.023207553,
-0.021494968,
-0.014685081,
-0.01846086,
0.024043618,
0.010390134,
0.006890796,
0.010713772,
0.013329847,
-0.030421987,
-0.002489654,
-0.007854968,
-0.012621889,
0.011057638,
0.0042275237,
-0.013154543,
-0.019741928,
0.003212783,
-0.00786171,
0.012723025,
0.0017142709,
-0.009520356,
-0.027064241,
0.0034100001,
0.009473159,
-0.006641325,
-0.004935482,
-0.022519823,
-0.007962847,
0.02744182,
-0.0041061593,
0.0049455957,
0.009095581,
0.0036544143,
-0.022627702,
0.00025305303,
-0.02473135,
-0.05442515,
-0.0030408502,
-0.010936273,
0.02796773,
0.019148592,
0.025095442,
0.0020969056,
0.0033762876,
0.024286347,
0.025216807,
-0.008070727,
-0.017759643,
-0.0185148,
-0.006088443,
0.0096552055,
-0.012311735,
-0.013275907,
0.02374695,
-0.010369906,
0.008643836,
0.01941829,
-0.0008824197,
-0.033874128,
0.020025112,
-0.019917233,
-0.007565042,
-0.009877707,
-0.013862502,
-0.016694335,
-0.05520728,
-0.009432704,
0.01232522,
0.018609194,
0.016802214,
0.006442422,
0.03163563,
-0.025769688,
0.02026784,
-0.020497084,
0.015952665,
-0.018245101,
-0.001928344,
-0.009028156,
0.0052456353,
0.040292952,
0.010504755,
0.011165516,
-0.00063842686,
-0.0059940484,
-0.00074588484,
0.0008149951,
-0.013033179,
-0.02037572,
-0.010403618,
-0.0006152496,
0.0029835394,
-0.010066495,
-0.020052081,
-0.03497989,
0.01944526,
-0.0039072568,
-0.016478576,
0.017894493,
0.025014533,
-0.017044943,
0.0565288,
0.0126690855,
0.020793753,
-0.008522471,
0.046846624,
0.0024626842,
0.012203855,
-0.002744182,
-0.018878892,
-0.0052051805,
0.022384973,
0.04050871,
0.03889052,
-0.0019165447,
-0.011347563,
-0.018744044,
-0.0036105884,
-0.01013392,
-0.023544677,
0.00023851458,
0.0035667622,
0.0119409,
0.0075987545,
0.0017597825,
0.011334078,
-0.0063682552,
-0.013687197,
0.016087513,
0.0056400695,
-0.022277094,
-0.023288462,
-0.00046396564,
-0.0139434105,
0.0082190605,
-0.018824954,
-0.010713772,
0.005653554,
-0.012028552,
0.03711051,
0.0075111026,
-0.02117133,
0.021872547,
0.016330242,
0.009412477,
0.009965358,
0.014334474,
-0.010949758,
-0.011023925,
0.020524053,
0.045498133,
-0.0009093895,
0.00019426718,
-0.015197509,
0.004497222,
0.011158775,
-0.003445398,
-0.004702867,
-0.018582225,
-0.032768365,
0.0030627633,
0.0056130993,
-0.0054007117,
-0.013525378,
-0.014617657,
-0.01867662,
-0.010093465,
-0.024394227,
-0.010639605,
0.024326801,
-0.05803911,
-0.019040711,
0.0013316362,
0.0036409295,
0.0105586955,
0.021764666,
0.0015524519,
-0.0087517155,
0.025189837,
-0.0101608895,
0.010275512,
-0.007625724,
0.000044800498,
-0.030475928,
0.016384182,
-0.010248542,
-0.010423846,
0.015898725,
0.010315967,
-0.0033004351,
-0.0061120414,
-0.011273396,
0.008913535,
0.021427544,
-0.012237568,
0.020079052,
-0.013464696,
0.015588571,
0.005269234,
-0.013188255,
0.006894167,
-0.019687988,
0.0010366535,
0.027495759,
0.00977657,
-0.017152824,
-0.011920673,
-0.014604172,
-0.002919486,
-0.022250123,
0.008778685,
-0.00933831,
-0.0019468858,
-0.012069006,
-0.0040252497,
-0.009540583,
-0.009237173,
-0.016330242,
0.010309224,
0.0015718364,
-0.011259912,
-0.00138979,
-0.0026750716,
0.00007922392,
-0.009432704,
-0.013747879,
0.003607217,
-0.004817489,
-0.015831301,
-0.019714959,
0.0053467723,
-0.024191953,
0.01328265,
-0.0068267426,
-0.00933831,
-0.01289833,
-0.0075582997,
-0.046738744,
-0.006223292,
-0.005168097,
0.012851132,
-0.007956105,
0.013363559,
0.00016023882,
-0.007173979,
0.030179258,
0.011873475,
0.0058221156,
-0.007416708,
0.013430984,
-0.010605892,
0.028749857,
0.004598359,
-0.03303806,
-0.01372091,
0.013370302,
-0.0019367721,
-0.009864221,
0.028075611,
0.0073425407,
0.02106345,
-0.003637558,
-0.008664063,
-0.0064019673,
0.015157054,
0.005154612,
-0.01059915,
-0.017112369,
0.01659994,
0.018069798,
-0.024609985,
-0.002371661,
0.008684291,
0.008171864,
-0.012251053,
-0.03330776,
-0.037380207,
0.0146446265,
-0.027414849,
0.0010720515,
0.0156155415,
0.022600733,
0.036085654,
0.016289787,
-0.010403618,
-0.010673317,
-0.0022604102,
-0.014833416,
-0.024690894,
0.0026801284,
-0.011907187,
-0.0202139,
-0.006931251,
-0.0010636233,
-0.02738788,
0.014860386,
-0.0075111026,
-0.022627702,
-0.032714423,
0.03028714,
0.009189975,
-0.01109135,
-0.010073238,
-0.0074369353,
-0.012298251,
-0.022668157,
0.02015996,
-0.014873871,
-0.035762016,
0.0012195428,
-0.002722269,
-0.032255936,
0.0078482255,
0.00000886265,
0.019229501,
0.0060479883,
0.026187722,
0.20755994,
0.006192951,
0.014900841,
0.026713634,
0.0064626494,
0.013559091,
0.009264142,
0.0023817746,
0.0012431414,
-0.00275261,
0.0070661,
0.008198833,
-0.008225803,
-0.00057395204,
0.026039388,
-0.00082679436,
-0.0075582997,
-0.0016316758,
-0.017678734,
-0.011388018,
0.010194602,
-0.018272072,
0.00016287259,
0.0026497876,
0.0070458725,
-0.0144423535,
-0.022465883,
-0.02281649,
0.0066345823,
0.005343401,
-0.03705657,
0.0110643795,
-0.0058895405,
0.006004162,
0.012453327,
0.009520356,
-0.02831834,
-0.0105586955,
-0.012028552,
-0.005302946,
-0.0141322,
0.006128898,
-0.02223664,
-0.0023480623,
-0.012648858,
-0.020577993,
0.00923043,
-0.022358004,
0.013201741,
0.023328917,
-0.040913258,
0.017260702,
0.003883658,
0.022209669,
-0.013275907,
-0.009634978,
0.007268374,
-0.0021238755,
-0.024596501,
0.021791637,
-0.0023784034,
0.008691033,
-0.040077195,
0.020996027,
-0.026700148,
0.012662343,
-0.017220248,
0.019957688,
0.04770966,
-0.045066614,
0.012304992,
-0.0037420662,
-0.022425428,
-0.0011293624,
-0.0078145135,
-0.019795869,
0.03177048,
0.028561069,
0.040104162,
0.043664183,
0.0039072568,
0.004247751,
-0.016721305,
0.0011125061,
0.010740741,
-0.020780267,
0.008097697,
0.006044617,
-0.027913792,
-0.023099674,
0.018069798,
-0.016478576,
-0.004031992,
-0.0065907566,
-0.015076145,
-0.018811468,
-0.021818606,
0.007376253,
-0.016856154,
-0.015494177,
-0.037488088,
0.07120039,
0.00397131,
0.011603776,
-0.015952665,
-0.0062974594,
0.0025301087,
0.0065334453,
0.0155481165,
-0.012203855,
0.016303273,
-0.017867524,
0.014833416,
0.007329056,
-0.0046758973,
0.012756738,
-0.0051276423,
-0.024771804,
0.012959012,
-0.0236121,
0.012891587,
-0.05291484,
0.004787148,
0.032660484,
-0.009304597,
0.0027340683,
-0.00081415224,
-0.010086723,
0.0076864064,
-0.030098349,
-0.0068874247,
-0.0003053071,
0.013262423,
-0.017786615,
0.009196718,
0.0027340683,
0.021441028,
-0.030610776,
-0.018083282,
0.022681642,
-0.0027863223,
0.008414593,
0.017260702,
0.0106598325,
-0.018824954,
-0.006031132,
0.016343728,
0.004608473,
-0.029720772,
-0.012365675,
-0.017907979,
0.008030272,
-0.011111577,
0.0071065547,
0.01514357,
-0.027805913,
-0.0011293624,
-0.026875453,
-0.0051647257,
0.015736906,
-0.038971428,
0.017422521,
0.01366697,
0.007592012,
-0.0120015815,
0.0007003732,
-0.16969427,
0.021751182,
0.03303806,
-0.023045734,
0.02722606,
0.041398715,
0.002331206,
0.010990213,
-0.0078482255,
0.013970381,
0.018110253,
0.025864083,
-0.024906654,
-0.029208343,
-0.010342936,
-0.008488759,
0.003812862,
0.026632724,
0.023099674,
-0.006378369,
0.015210994,
-0.028803797,
0.018959802,
-0.015237964,
-0.00021913,
0.015467207,
0.015534632,
0.016438121,
-0.00010266452,
-0.016937064,
0.00056215277,
-0.008704518,
0.026322572,
-0.0032178399,
0.025081959,
0.003458883,
-0.0078145135,
-0.017894493,
-0.008664063,
0.02297831,
0.029612891,
0.013619773,
0.011023925,
-0.025378626,
0.009601265,
0.050190885,
-0.0031925556,
-0.009594523,
0.010592408,
0.0008394365,
0.037380207,
-0.021414058,
0.01325568,
0.015184024,
0.022668157,
-0.00094478746,
-0.014213109,
0.02667318,
-0.01098347,
0.005872684,
-0.013141058,
0.0045916163,
0.045390252,
-0.008030272,
-0.0034116856,
-0.04768269,
-0.0063109444,
0.022964824,
-0.04590268,
0.026012417,
-0.014037806,
-0.008610124,
-0.0017580969,
-0.006728977,
-0.0000872306,
0.020753298,
0.0110643795,
0.02210179,
-0.0021457884,
-0.0024491993,
-0.0069514783,
0.023517707,
-0.041587505,
-0.021737697,
-0.010342936,
-0.008340425,
-0.009136036,
0.004173584,
0.017206762,
-0.0073964805,
-0.0023733466,
-0.017678734,
0.009250658,
-0.021616332,
0.023423312,
0.0070998124,
-0.02730697,
0.0031756994,
-0.008212319,
0.005528819,
-0.016667366,
-0.0051815817,
-0.00465567,
0.0067424616,
0.02475832,
0.030718656,
-0.004274721,
-0.0065469304,
0.024947109,
-0.016357211,
-0.009884449,
-0.031015323,
0.007167237,
0.026241662,
0.011239684,
0.027751973,
-0.0051276423,
0.011711656,
-0.019836323,
-0.011752111,
0.08090954,
0.01232522,
-0.013390529,
0.005420939,
-0.0072481465,
-0.008279743,
-0.11834369,
-0.007517845,
0.014091745,
0.03179745,
-0.00275261,
0.0059165102,
-0.0009093895,
0.02815652,
-0.023949225,
0.024218922,
-0.027859852,
-0.020106021,
0.019768897,
-0.015076145,
-0.010949758,
-0.021036481,
0.024218922,
-0.022209669,
0.000890005,
0.028884707,
0.012554464,
-0.007989817,
-0.002717212,
-0.025351657,
0.015669482,
-0.017382067,
-0.023099674,
0.021764666,
0.008697776,
0.0017395552,
-0.02990956,
-0.017233733,
0.019027228,
0.015399783,
-0.014765991,
-0.009365279,
-0.023531191,
-0.045336314,
0.030691685,
0.008306713,
-0.011563322,
0.022250123,
0.018784499,
-0.006074958,
0.009446189,
-0.016276302,
0.0076729213,
0.0028453188,
0.015763875,
0.016168423,
-0.02303225,
0.011145289,
-0.03338867,
-0.013822047,
-0.003853317,
-0.034818072,
0.021656787,
0.024960594,
-0.0068537123,
-0.007173979,
-0.0050804447,
-0.018690104,
-0.020618448,
-0.00065949705,
0.03015229,
-0.009324824,
-0.007180722,
-0.021791637,
0.04417661,
-0.01665388,
0.001415917,
-0.007618982,
-0.026187722,
0.006469392,
-0.036193535,
0.00039738385,
-0.0099923285,
-0.003927484,
-0.010882333,
-0.01862268,
-0.028803797,
-0.019971171,
0.01665388,
-0.035788987,
0.026861968,
-0.018919347,
-0.005107415,
0.01068006,
0.016532516,
-0.018352982,
-0.002489654,
0.062354285,
-0.00035461134,
-0.021333149,
-0.004989422,
0.02528423,
0.013700683,
0.0013493352,
-0.013424241,
0.017597824,
-0.0058322293,
-0.006732348,
-0.07384344,
0.016613426,
0.00356002,
0.0020176817,
0.008879822,
-0.013916441,
0.00956081,
-0.002467741,
-0.010868848,
0.027158637,
-0.023544677,
0.004399456,
-0.0049253684,
-0.023086188,
-0.029612891,
-0.0037319525,
0.021103906,
-0.0050804447,
0.034791104,
0.026255146,
-0.011482412,
-0.027576668,
0.029235315,
0.01068006,
0.0057614334,
0.013889471,
-0.0055153337,
0.013168028,
-0.016640395,
0.0076594367,
0.0068503413,
-0.036436263,
-0.0299635,
-0.0028368908,
-0.00031626358,
0.0018002373,
-0.021845575,
0.018811468,
0.010410361,
0.01402432,
-0.0228974,
-0.030098349,
0.009068611,
-0.0031976125,
-0.014064775,
0.010127177,
-0.055557884,
0.0072076917,
0.019822838,
-0.027482275,
0.04077841,
0.006931251,
0.017274188,
-0.02544605,
-0.029612891,
0.0066379537,
-0.023504222,
-0.0051883245,
-0.0055321897,
-0.046765715,
0.016721305,
0.022115275,
0.025864083,
0.0051175286,
0.009648463,
0.021373603,
-0.02199391,
-0.009223687,
-0.010046268,
-0.023652555,
-0.02034875,
0.016141454,
0.014873871,
0.016451607,
0.007389738,
-0.009877707,
-0.026686663,
0.0013055091,
-0.018164191,
0.013221968,
-0.010046268,
-0.0051613543,
-0.023288462,
0.0021575878,
0.0262956,
-0.01585827,
-0.01591221,
0.019580109,
0.003954454,
0.0047365795,
0.019189047,
0.0124331,
0.041992053,
0.00838088,
0.011617262,
0.01856874,
-0.014563718,
0.00956081,
0.009608008,
0.026605753,
-0.0054681366,
-0.013410756,
-0.012015067,
-0.0065064756,
0.0010383391,
0.038162332,
-0.022344518,
-0.034305647,
-0.0054715076,
-0.01846086,
0.0098574795,
0.01875753,
0.013168028,
0.02390877,
0.0020328523,
0.016195394,
0.0076998915,
0.012884844,
0.00421741,
0.008535957,
0.011313851,
0.0039814236,
-0.0026143896,
-0.00042625002,
0.041911144,
0.02571575,
0.023450281,
-0.015440238,
0.012183628,
-0.0022368117,
0.02990956,
0.004568018,
-0.028776826,
-0.007018903,
-0.0012852817,
0.011192487,
-0.020389205,
0.039915375,
-0.021373603,
0.096605994,
0.02634954,
-0.019512685,
-0.013788334,
-0.029882591,
0.011745368,
0.022533307,
0.024717866,
-0.014091745,
-0.027644094,
0.026808027,
-0.019310411,
0.0058356007,
-0.035708077,
-0.0026902421,
0.03743415,
-0.003330776,
-0.013545605,
0.008165121,
-0.027576668,
-0.0066345823,
-0.01686964,
-0.013127573,
0.024299832,
-0.021521937,
0.005100672,
0.0032279536,
0.00029097937,
-0.010848621,
-0.020618448,
0.031231083,
-0.031096233,
-0.032984123,
-0.007214434,
0.03187836,
0.008482017,
-0.013498409,
-0.0027408106,
0.037622936,
0.026039388,
0.0055321897,
-0.006074958,
-0.0078077707,
-0.015750391,
0.027374394,
-0.00835391,
0.01848783,
-0.012136431,
-0.012183628
] |
DNA polymerase β (Pol β) is an error-prone enzyme which has been found to be overexpressed in several human tumors. By using a couple of recombinant CHO cells differing only from the exogenous expression of Pol β, we showed here that cells overexpressing Pol β are much more sensitive to IR treatments by increasing apoptosis. We also found that the surviving cells displayed an hypermutator phenotype which could be explained by different pathways involving Pol β, such as (i) an increased capacity to incorporate into DNA the mutagenic dGTP analog, 8-oxo-dGTP, one of the most | [
-0.043880932,
-0.025564147,
-0.03192543,
-0.02368618,
-0.04620855,
0.009396444,
-0.0071151117,
0.035073005,
-0.0045825024,
0.02192724,
-0.003286441,
-0.004106398,
-0.01551306,
0.022271093,
-0.019692196,
-0.0076375036,
0.021543711,
0.0060405713,
-0.019216092,
0.009422895,
-0.035945863,
0.01352268,
0.011968729,
-0.011373599,
0.000036394897,
0.0055743856,
0.009184842,
-0.049990933,
-0.004827167,
-0.017933255,
0.020128625,
-0.006119922,
-0.014349249,
-0.018938364,
-0.003369098,
-0.009872548,
0.00619266,
0.0047048344,
0.026846983,
-0.017258774,
0.013978946,
0.013403654,
0.009912224,
0.009198068,
-0.009740297,
0.0004194841,
0.0115852,
-0.014018621,
0.0016448736,
0.003630294,
0.015275007,
0.013304465,
-0.019268991,
0.0014357516,
-0.012894487,
-0.003997291,
-0.0011307473,
0.010666055,
-0.014785678,
0.000011623636,
0.0013663197,
-0.010996683,
-0.025326096,
0.026846983,
0.0044767014,
0.014349249,
0.016042065,
0.012828361,
0.0059413826,
-0.008523586,
0.02528642,
0.017576177,
-0.02655603,
-0.0022681071,
0.012854812,
-0.010487516,
-0.027018908,
0.014177323,
0.012312582,
0.018581286,
0.036739368,
-0.016875247,
0.006830772,
0.024069708,
0.014362475,
-0.0008141711,
-0.028407546,
0.010467678,
-0.0013208584,
-0.014600527,
0.050149634,
0.020075724,
0.02414906,
0.017748104,
-0.016425593,
0.014759228,
-0.011942279,
0.034120794,
-0.011757127,
-0.029386206,
0.0011009908,
-0.0021275904,
-0.0018680474,
-0.01445505,
-0.026899884,
0.0005265249,
0.025061592,
-0.018991265,
0.005157795,
-0.009561758,
-0.011261186,
0.046816908,
-0.0022466164,
-0.025299644,
0.02076343,
0.0013018473,
0.03721547,
-0.00049470196,
-0.024030033,
-0.027508238,
0.02358038,
0.035363957,
0.024651613,
-0.026437005,
0.009502245,
-0.0006215804,
-0.018343234,
0.014931154,
0.002919444,
0.022006592,
0.027799191,
0.0035807,
0.034041446,
0.019295443,
-0.0288043,
-0.0061033904,
-0.025617046,
-0.018978039,
-0.01608174,
-0.041050754,
0.0064108744,
0.015460159,
-0.0174307,
0.019414468,
0.01786713,
0.012629985,
0.015698211,
0.030364864,
0.013767344,
0.022218192,
0.0075978283,
-0.01497083,
0.01892514,
-0.008219409,
0.006086859,
0.016028838,
-0.00014888587,
0.008391336,
-0.015155981,
-0.016782671,
0.019401243,
-0.0033046256,
0.004684997,
0.005590917,
0.008649225,
0.03010036,
-0.013284627,
0.017695203,
0.019335117,
-0.03351244,
-0.0021689187,
0.021504037,
-0.021490812,
0.02019475,
-0.0059380764,
0.013608643,
-0.008331822,
0.01039494,
-0.0027028827,
-0.00985271,
-0.01833001,
0.006420793,
0.008854214,
-0.003109555,
-0.0075383154,
0.00016820693,
-0.0075779906,
-0.009872548,
-0.006100084,
-0.0037427074,
-0.004721366,
-0.0068770596,
0.025696399,
-0.01559241,
-0.6377679,
-0.027217286,
-0.028381096,
0.004688303,
-0.010553641,
0.034226596,
0.02068408,
-0.01553951,
-0.023038149,
0.01740425,
-0.015526284,
-0.0076705664,
0.031237721,
-0.03192543,
-0.020075724,
-0.040706903,
0.018634187,
-0.013529292,
0.00917823,
0.008259084,
-0.027190836,
-0.015314682,
-0.019665746,
0.011810027,
0.0045262957,
0.016068514,
0.03382984,
-0.01895159,
0.0045097643,
0.036474865,
-0.021080833,
0.024611939,
0.00095303485,
-0.014574076,
0.049250327,
0.0058157444,
0.010289139,
0.010996683,
0.0289101,
0.028989451,
-0.008536812,
0.0051677134,
0.03263958,
-0.0020399739,
-0.0049197427,
0.020657629,
0.0073399385,
0.0071349493,
0.02249592,
0.020842781,
0.011631489,
0.011757127,
-0.017443927,
0.003630294,
0.012947387,
0.018052282,
0.00417583,
-0.038934737,
0.018052282,
-0.008926952,
-0.0033261164,
0.02265462,
-0.016306566,
-0.025458345,
-0.025378995,
0.0072209127,
-0.028486896,
0.005290046,
-0.0009100532,
0.0020895682,
0.017391026,
0.006764646,
-0.009244355,
-0.0028764624,
0.0020697305,
0.020366676,
0.0033195037,
0.013608643,
0.0033294226,
0.013568968,
0.0026565949,
-0.01127441,
-0.036607116,
0.019136742,
0.02127921,
0.0017143055,
-0.02604025,
0.013020125,
-0.0083714975,
-0.0023276203,
0.026807308,
-0.0041692173,
-0.010540416,
-0.010970233,
-0.0084243985,
-0.0036997257,
0.023527479,
-0.0031541898,
0.0077300793,
-0.013489617,
-0.019718645,
-0.014825353,
0.0050784443,
0.013469779,
0.009356769,
0.009766747,
-0.019070616,
-0.009965124,
0.022681072,
-0.011122322,
0.011558751,
0.017338125,
0.005838888,
-0.0010596623,
0.023540704,
-0.026132826,
0.011876153,
0.01073218,
0.0016027186,
-0.036395516,
0.0102957515,
-0.018898688,
-0.009568371,
-0.0011076033,
0.022363668,
0.0046221777,
-0.0011365333,
-0.023329102,
0.023157176,
-0.003119474,
0.005263596,
-0.011644714,
0.027005684,
-0.028248845,
-0.009171617,
-0.007895393,
0.02014185,
-0.0034021607,
0.012782074,
-0.013251564,
-0.018753212,
0.013337528,
-0.0037923018,
0.014216999,
-0.011479399,
-0.014838579,
-0.03343309,
0.0015357664,
0.019692196,
0.023262978,
0.014150873,
0.021556936,
0.0024830152,
0.02652958,
0.016610743,
0.00065588305,
-0.002621879,
-0.017364576,
-0.014216999,
-0.0070291483,
0.00047858382,
0.0075978283,
0.007816043,
0.0071481746,
0.007194462,
-0.0072738132,
0.0027094954,
-0.0030996362,
-0.01840936,
-0.03213703,
0.002147428,
-0.0070291483,
-0.010996683,
-0.01825066,
0.011221509,
0.039728243,
-0.0065794946,
0.005128038,
-0.006146372,
-0.01241177,
-0.0074788025,
0.0019077228,
-0.018726762,
-0.0070291483,
0.030523565,
0.014071522,
0.031846076,
0.0019325198,
0.0071018864,
0.022218192,
0.00023247272,
0.025511246,
-0.007095274,
-0.0027475175,
0.007690404,
-0.008523586,
0.015433709,
0.021094058,
0.013793794,
0.025590597,
0.00002996315,
-0.010037862,
0.025669947,
-0.033036336,
0.01613464,
-0.03131707,
0.0071481746,
-0.018277109,
0.013701219,
-0.0038055268,
-0.01352268,
0.015856912,
-0.016888471,
-0.0149840545,
0.004665159,
0.000005902224,
-0.028195944,
0.0043146936,
0.0059479955,
-0.023487804,
-0.010037862,
0.012821749,
0.0078094304,
-0.020049274,
-0.019586395,
0.0103486525,
0.013046576,
0.0071415617,
0.014825353,
0.001803575,
-0.007320101,
0.0063414425,
0.0054785036,
0.010824757,
0.001233242,
0.009574983,
0.015155981,
-0.013992172,
0.042108767,
0.016385917,
-0.012557247,
-0.0051082005,
-0.0035873123,
0.010494129,
0.010798306,
-0.010771856,
0.040759802,
0.014309574,
-0.005528098,
0.00443372,
-0.036765818,
0.009898999,
-0.006738196,
0.034200147,
0.0032335406,
-0.008305372,
0.031766724,
0.020247651,
0.04940903,
0.020446027,
0.013542517,
-0.007796205,
0.0025094654,
0.0017357963,
0.0017589403,
-0.01179019,
0.0054785036,
-0.03578716,
-0.0029359756,
0.01895159,
-0.0023028231,
0.006394343,
0.026516356,
-0.027190836,
0.0067415023,
0.007875556,
-0.0017655528,
0.02994166,
0.012054692,
0.008014419,
-0.019943474,
-0.043140326,
0.024043258,
0.024387112,
-0.0018168001,
-0.017708428,
-0.0287514,
-0.00959482,
-0.0049528056,
0.010877657,
-0.008960015,
0.02991521,
0.002883075,
0.023950683,
-0.016028838,
-0.012510958,
0.022403345,
-0.036633566,
0.032533783,
-0.0060471836,
0.02068408,
-0.005061913,
-0.0060703275,
-0.0008352487,
0.029306855,
0.0286456,
0.010487516,
0.013013513,
-0.008060708,
-0.016544618,
-0.016491719,
-0.006916735,
-0.0028103369,
0.0035013491,
-0.014164098,
-0.0058421944,
0.02003605,
-0.0035542496,
0.008113608,
-0.005663655,
-0.012021629,
-0.005164407,
-0.00959482,
-0.0018961509,
0.014798903,
0.0402308,
-0.014164098,
0.010414778,
0.022601722,
0.00056496036,
-0.029597806,
-0.02766694,
0.016663644,
-0.029862309,
0.005726475,
0.0074060643,
0.017642302,
-0.014613751,
-0.0031277395,
0.01825066,
0.008543424,
-0.022667846,
-0.007558153,
0.0032186622,
0.0038551209,
0.0073267138,
0.019202866,
0.024942566,
0.017959706,
0.004889986,
-0.0041824426,
0.016769445,
0.012491121,
-0.01556596,
-0.014574076,
0.026780857,
0.0089666275,
0.005495035,
0.002681392,
-0.020459253,
0.0019523576,
0.009244355,
-0.020776656,
-0.0022052878,
0.017100073,
0.01204808,
0.009403056,
0.010196564,
0.014666652,
-0.028143045,
-0.014613751,
0.01954672,
-0.019837672,
-0.009727072,
0.015737886,
-0.016888471,
-0.05290046,
-0.0106462175,
-0.01298045,
-0.005799213,
0.01383347,
-0.009733684,
-0.014124422,
-0.0066852956,
0.010269302,
-0.0143757,
0.008391336,
-0.007849106,
0.015870137,
-0.010527192,
0.0067315833,
-0.018290333,
-0.0100577,
-0.024479687,
0.009059204,
-0.0403366,
-0.012021629,
-0.010533804,
0.013873145,
0.013106089,
0.006060409,
-0.008854214,
-0.0008538465,
0.034094345,
-0.016333017,
-0.0035509432,
0.0029458944,
-0.03213703,
-0.0053693964,
0.000599263,
0.002881422,
-0.029095253,
-0.018872239,
0.008530199,
-0.0037460136,
-0.009184842,
-0.0018449035,
-0.0013043269,
-0.0035443308,
0.022178518,
0.02019475,
0.06115293,
0.01631979,
-0.015446934,
-0.011538913,
-0.022165293,
-0.04396028,
-0.033935644,
-0.016227216,
-0.019493818,
-0.0014622017,
-0.0036269878,
-0.0020961806,
-0.014388924,
0.0013026738,
-0.013443329,
0.0014555892,
0.001684549,
0.017047172,
0.032745384,
-0.004519683,
0.016015613,
-0.013483005,
0.0011538912,
0.006857222,
-0.038723137,
0.02122631,
-0.01491793,
-0.009330318,
-0.0039476966,
-0.0003312478,
-0.028169494,
0.022800097,
-0.024003584,
-0.00053231086,
0.024387112,
0.009032753,
-0.017126523,
-0.016346242,
-0.01073218,
-0.010533804,
0.0026979235,
0.01218033,
-0.01145295,
-0.023289427,
-0.003144271,
0.003299666,
0.004066723,
0.00695641,
-0.030893868,
0.008100383,
0.040019196,
0.016610743,
-0.014798903,
0.003726176,
0.0042088926,
-0.030708717,
-0.0014324452,
-0.030761616,
-0.030840967,
0.013026738,
-0.00041597118,
0.0229059,
0.037665125,
0.0345969,
0.005326415,
0.0030087135,
0.037797377,
0.0023739082,
0.00022689337,
0.0006554698,
0.010811531,
-0.019824447,
0.013535905,
0.0055743856,
-0.010196564,
0.020088948,
-0.04726656,
0.011254572,
0.016623968,
-0.011181834,
0.0052834335,
0.011571975,
-0.020459253,
-0.0402837,
-0.0076441164,
-0.009680784,
0.0037691577,
-0.02696601,
0.0061364532,
-0.0003649305,
0.017007498,
0.017602628,
-0.0117835775,
0.0051544886,
-0.0036104564,
0.027058585,
-0.008060708,
0.0057496186,
-0.0023672956,
-0.0075449278,
0.0074788025,
0.020340227,
0.019903798,
0.011221509,
-0.0071151117,
-0.017721653,
-0.012153881,
0.007697017,
0.00545536,
-0.021504037,
-0.035972312,
0.0016754568,
-0.012689497,
-0.0171662,
-0.008245859,
0.00238548,
-0.031528674,
-0.0038121394,
0.01553951,
-0.012517571,
0.013456554,
0.010580092,
-0.032718934,
0.016068514,
0.012160493,
0.03668647,
-0.016121415,
0.022376895,
0.015671762,
-0.0039774533,
-0.032851186,
-0.016557844,
0.012279519,
0.0073068757,
0.01959962,
0.019414468,
0.0058157444,
-0.028936552,
-0.006090165,
0.00094807544,
-0.009898999,
-0.02425486,
0.014521176,
-0.020922132,
0.00837811,
-0.008239247,
0.004565971,
-0.027296636,
0.022614947,
-0.019943474,
0.016663644,
0.0021871033,
-0.014719552,
-0.03467625,
0.0064604688,
0.0037724639,
0.008490523,
-0.014415375,
-0.029068802,
-0.0012968878,
-0.038114782,
0.0026532887,
0.0006141413,
-0.001707693,
0.0288043,
-0.013820245,
0.0073134885,
0.0039476966,
-0.009641109,
-0.009522082,
0.002266454,
-0.0008472339,
0.035284605,
-0.019070616,
-0.00015425857,
0.003131046,
0.005161101,
-0.0017374494,
-0.009753522,
0.0054421346,
-0.029280404,
-0.02190079,
0.003178987,
0.025299644,
0.037400626,
-0.013231727,
-0.0050519938,
-0.023104275,
0.006632395,
-0.032666035,
-0.026503129,
0.0050387685,
-0.03226928,
-0.01179019,
-0.020181525,
0.013483005,
0.02030055,
0.013582192,
0.0032930535,
-0.01833001,
0.030364864,
-0.018369684,
0.0006649753,
0.004222118,
0.016954597,
-0.00083318225,
0.008192958,
0.009389832,
-0.012299357,
-0.0080739325,
-0.016346242,
-0.033909194,
-0.024347436,
-0.027904993,
0.02231077,
0.023950683,
-0.016557844,
0.014812129,
0.005260289,
0.018422585,
-0.0027045358,
-0.011558751,
0.01843581,
-0.01445505,
0.027481789,
-0.0004818901,
-0.009971737,
-0.04869487,
-0.0052834335,
-0.01572466,
-0.02141146,
-0.008688901,
-0.039728243,
-0.010983458,
-0.013740894,
0.004804023,
-0.0067679523,
-0.0018184533,
-0.005600836,
-0.024638388,
0.01616109,
0.019335117,
0.008060708,
-0.035258155,
0.023858108,
0.0002425982,
0.007617666,
-0.027428888,
-0.0019374792,
-0.015698211,
-0.023249751,
0.0014258326,
0.00049759494,
-0.014097972,
0.040944956,
0.02428131,
-0.02198014,
-0.028248845,
-0.013740894,
-0.033168588,
-0.015433709,
-0.005061913,
0.008199571,
0.010070925,
0.026886659,
-0.019070616,
0.008318597,
-0.008814539,
0.028354647,
-0.023924233,
-0.022509145,
0.009105491,
-0.02019475,
0.009727072,
0.012015017,
-0.021755314,
-0.006053796,
0.026198952,
0.010004799,
-0.027243737,
0.042214565,
-0.01954672,
0.019877348,
-0.003931165,
0.013873145,
0.009032753,
0.025405446,
0.04155331,
-0.030550014,
0.0008149977,
0.020604728,
-0.0011786884,
-0.01238532,
0.011366986,
0.0055743856,
-0.0017490215,
-0.009489019,
-0.0010836328,
-0.037744477,
-0.013483005,
0.00094807544,
0.0069365725,
0.0047775726,
0.018343234,
0.0005500821,
-0.012577084,
-0.011935666,
-0.014560851,
-0.015063406,
-0.011208285,
-0.017258774,
0.021834664,
-0.0033740574,
-0.011882765,
-0.016584294,
0.008933565,
-0.008252472,
0.00010714409,
-0.0066753766,
-0.023540704,
-0.029201053,
0.011009908,
-0.0036831945,
-0.0011919135,
-0.018964814,
0.01892514,
0.0008092117,
-0.011406661,
-0.0030913705,
-0.004139461,
0.004559358,
0.0014795597,
-0.016253665,
-0.017748104,
-0.0045262957,
-0.015155981,
-0.006427406,
-0.018184533,
0.012629985,
0.19149967,
-0.020657629,
0.020525377,
0.014336024,
0.013621869,
0.006321605,
-0.008047482,
-0.011360373,
-0.028672049,
-0.0014836926,
0.019242542,
-0.0052404515,
-0.014097972,
-0.00026057608,
0.016531393,
0.014269899,
-0.02663538,
-0.012034854,
-0.033776943,
0.006298461,
0.012524184,
-0.012510958,
0.019335117,
-0.0046122586,
0.016227216,
0.0050090123,
-0.03343309,
0.0019705421,
0.02428131,
0.012517571,
-0.04509764,
-0.008854214,
0.0014787331,
-0.007763142,
0.010117212,
0.015486609,
-0.0038352832,
-0.02198014,
-0.017020723,
-0.014640202,
-0.02030055,
0.019797998,
-0.0014555892,
-0.009237743,
-0.004972643,
-0.0024482994,
0.014560851,
-0.0066357013,
-0.00059595675,
0.014164098,
-0.036131013,
-0.0066059446,
-0.0035079618,
0.02577575,
0.030311963,
0.00038414824,
0.0050751376,
-0.004308081,
-0.0012448139,
0.031846076,
-0.0011431458,
0.0047775726,
-0.03705677,
0.01859451,
-0.03010036,
0.032956988,
-0.011056196,
0.0057463124,
-0.0017457152,
-0.031687375,
0.010388328,
0.01799938,
-0.010090763,
0.011962117,
-0.00545536,
-0.0069696354,
0.019308668,
0.029253954,
0.030999668,
0.014600527,
0.02477064,
0.0075118653,
-0.018872239,
-0.0076771793,
-0.012292744,
-0.0058686445,
0.01851516,
0.0017341431,
-0.011849702,
0.00602404,
0.015275007,
-0.009079041,
-0.00011561643,
0.019996373,
-0.018753212,
-0.011571975,
-0.012504346,
0.006976248,
-0.022218192,
-0.0129209375,
-0.036236815,
0.06570237,
0.009832873,
0.008550037,
-0.0034550612,
-0.016280117,
0.0017308369,
0.026159277,
0.0011514116,
-0.01499728,
-0.0021755314,
-0.029571356,
0.009416281,
-0.005468585,
0.01564531,
0.023818431,
0.008298759,
-0.01616109,
0.016280117,
0.01210098,
0.015618861,
-0.044171885,
-0.023368778,
0.015195657,
-0.010004799,
0.008431011,
-0.023963908,
0.0034682862,
-0.021186633,
-0.008702125,
-0.0037658515,
-0.0027078423,
0.02122631,
-0.0051544886,
0.0059876707,
-0.015433709,
0.0070423735,
-0.022152066,
-0.00015973458,
0.026913108,
-0.0055115665,
-0.010044474,
0.00033000793,
-0.0015465119,
-0.013324303,
0.0025127719,
0.01616109,
0.023196852,
0.00091087975,
-0.005802519,
-0.02487644,
-0.0034219983,
-0.0073267138,
0.0046916096,
0.01378057,
-0.026079927,
-0.030973218,
-0.015737886,
-0.013687993,
0.020578278,
-0.035284605,
0.017047172,
0.019097066,
0.006486919,
-0.016015613,
0.008854214,
-0.16610745,
0.010580092,
0.0038716523,
-0.016544618,
0.03250733,
0.009786584,
0.011677776,
-0.01895159,
0.010474291,
0.005848807,
0.0065894136,
0.0060571027,
-0.05681509,
-0.012993676,
0.0051082005,
-0.013033351,
0.0018581286,
0.036236815,
0.021623062,
0.0026846982,
0.008100383,
-0.018726762,
0.025749298,
0.0046552406,
-0.012114205,
0.02192724,
0.0033294226,
0.0056140614,
0.0025904693,
-0.016544618,
-0.0077300793,
0.026979234,
0.020181525,
-0.002646676,
0.011479399,
-0.004023741,
-0.005432216,
-0.023858108,
-0.0038749585,
-0.0064373245,
0.028592698,
0.046446603,
-0.0072804256,
-0.0062091914,
0.001607678,
0.022046266,
0.014296349,
-0.020049274,
-0.001863088,
0.022165293,
0.028063694,
-0.025088042,
0.005501648,
0.010262689,
0.01729845,
-0.0025259969,
0.010183338,
0.018687086,
-0.018726762,
0.01616109,
-0.005359478,
-0.01605529,
0.032057676,
-0.00049718167,
-0.003617069,
-0.024043258,
-0.0004475875,
0.009707234,
-0.037797377,
0.005564467,
-0.0066522327,
0.023818431,
0.007234138,
-0.018012606,
0.011333923,
-0.0097006215,
-0.005372703,
0.017483601,
-0.00010115146,
-0.021120507,
-0.0058653383,
0.020432802,
-0.023355553,
-0.023130726,
-0.011234735,
0.029544907,
-0.0022829855,
0.028592698,
-0.010527192,
-0.008272309,
-0.0016994273,
-0.026172502,
-0.003643519,
-0.019308668,
0.0063050734,
0.018607736,
0.0068109343,
0.0006955584,
0.0011646367,
-0.01292755,
0.01613464,
0.00028929938,
-0.008199571,
0.012451446,
0.040151447,
0.008001194,
-0.013568968,
-0.006596026,
0.06580817,
0.013727669,
-0.0288043,
-0.001696121,
-0.013767344,
0.018091956,
-0.00616621,
0.034120794,
-0.0028037243,
0.018316783,
0.0036534378,
-0.03144932,
0.07025181,
0.006119922,
-0.00083855493,
0.0027590895,
0.006857222,
-0.011426499,
-0.13225114,
-0.015764337,
-0.007961519,
0.027058585,
-0.0077763675,
0.0010927251,
-0.0023177015,
0.034358848,
-0.015790787,
0.028248845,
-0.0025838567,
-0.0058124377,
0.013443329,
0.0016357814,
-0.011314086,
0.025233518,
0.0017886967,
0.0039476966,
-0.019321892,
0.024056483,
-0.0011026439,
0.009323706,
-0.0007463924,
-0.00866245,
0.014243448,
-0.02368618,
-0.032375082,
0.0018217595,
-0.0034914303,
0.018792888,
-0.017457152,
-0.008708738,
0.006311686,
0.008933565,
-0.00912533,
0.009264193,
-0.01911029,
-0.024638388,
0.032375082,
0.003251725,
-0.003676582,
-0.005243758,
-0.0032781754,
0.018766439,
0.019533494,
0.0008257431,
0.004767654,
0.00034426627,
-0.0024185427,
-0.013846695,
-0.037347723,
0.004232037,
-0.029148152,
-0.014336024,
0.012147268,
-0.023540704,
0.03785028,
0.035549108,
-0.018753212,
-0.0018184533,
0.017113298,
0.0010671015,
-0.02539222,
0.0019292136,
0.02068408,
-0.012424995,
-0.00593477,
-0.029624257,
0.023421679,
-0.017695203,
-0.017562952,
-0.00076085737,
-0.011909216,
-0.0073465514,
-0.020419577,
-0.02078988,
-0.01848871,
-0.001707693,
0.007234138,
0.0042816307,
-0.007121724,
-0.008490523,
0.025273195,
-0.010256076,
0.0052404515,
0.012286131,
0.01616109,
-0.005762844,
0.011076033,
-0.005395847,
-0.015327908,
0.04483314,
-0.00027979384,
-0.034887854,
-0.010884269,
0.025220294,
-0.013092863,
-0.01843581,
0.026304753,
0.011909216,
-0.026780857,
-0.034887854,
-0.058507908,
0.013423491,
-0.016465267,
-0.011115709,
0.0036236814,
-0.0100510875,
0.006146372,
0.0032351937,
0.006328217,
-0.009905611,
-0.021160183,
-0.0001851516,
-0.026437005,
-0.016187541,
-0.029756509,
0.004222118,
0.009217905,
-0.01773488,
0.0100510875,
0.0151427565,
0.0014779066,
-0.0020317081,
0.016994273,
-0.01846226,
-0.012319194,
-0.027931442,
-0.007849106,
0.024585487,
-0.013192052,
-0.009733684,
-0.016333017,
-0.039516643,
-0.010262689,
0.007928456,
-0.0033029723,
-0.029439105,
0.0012241497,
0.03599876,
0.017179424,
0.020604728,
-0.016742995,
-0.044330586,
0.0080739325,
0.0071018864,
0.0040501915,
-0.00979981,
-0.032771833,
-0.0058455006,
0.012940775,
-0.0012291091,
0.054487474,
0.017695203,
-0.004863536,
-0.031528674,
-0.02492934,
-0.0068506096,
-0.016452042,
0.0046783844,
0.003993985,
0.0029574663,
0.019388018,
0.006195966,
0.008470686,
0.026648605,
0.004923049,
-0.01181664,
-0.017933255,
-0.027799191,
-0.0061860476,
-0.051128294,
-0.028222395,
0.031978328,
0.013568968,
0.004126236,
-0.0016299954,
-0.00020571252,
-0.032877635,
0.010798306,
-0.010718956,
0.019956699,
0.020102175,
0.00545536,
-0.034755602,
0.00912533,
0.034147248,
-0.005898401,
0.004506458,
0.018475486,
0.020882456,
0.019731872,
0.00959482,
0.027534688,
0.010282527,
0.0070093106,
-0.028513348,
-0.0009290643,
-0.021080833,
-0.0019903798,
-0.00897324,
0.014507951,
0.0036236814,
-0.014600527,
0.0009703928,
-0.026807308,
-0.018052282,
0.011380211,
-0.033750493,
-0.013767344,
0.009131942,
-0.0011952197,
0.0050850566,
0.00894679,
-0.0011489318,
0.021570163,
-0.003213703,
0.009727072,
0.009495633,
0.0050453814,
-0.010269302,
0.034279495,
0.0065695755,
0.010097375,
0.013674769,
-0.002349111,
0.019414468,
0.01892514,
0.021556936,
-0.028566247,
0.0015093163,
-0.018779663,
0.019507045,
-0.008953403,
-0.028592698,
-0.0074920272,
0.009290643,
-0.0047775726,
0.0043477565,
0.027428888,
-0.017668754,
0.09040689,
0.0067778714,
-0.022125617,
-0.012458058,
-0.02003605,
0.00798797,
0.0062786234,
0.024003584,
-0.0011109096,
-0.033195037,
0.0048833736,
-0.022350444,
0.038987637,
-0.029412655,
-0.028777849,
0.037136123,
0.0029822635,
-0.00090426725,
-0.022588495,
-0.016174315,
0.022813322,
-0.018263884,
0.00065009703,
0.0068109343,
-0.022046266,
0.016954597,
0.031528674,
0.007201075,
-0.010580092,
-0.024559038,
0.021940466,
-0.024492912,
-0.039939847,
-0.006331524,
0.014362475,
-0.019969923,
-0.004093173,
-0.0146534275,
0.034120794,
0.023725856,
-0.009072429,
-0.0017225712,
0.011181834,
-0.032718934,
0.017443927,
0.013648318,
-0.007736692,
0.018541612,
-0.013701219
] |
BACKGROUND HOX genes are a family of developmental genes that are expressed neither in the developing forebrain nor in the normal brain. Aberrant expression of a HOX-gene dominated stem-cell signature in glioblastoma has been linked with increased resistance to chemo-radiotherapy and sustained proliferation of glioma initiating cells. Here we describe the epigenetic and genetic alterations and their interactions associated with the expression of this signature in glioblastoma. RESULTS We observe prominent hypermethylation of the HOXA locus 7p15.2 in glioblastoma in contrast to non-tumoral brain. Hypermethylation is associated | [
-0.025546549,
0.0108261295,
-0.007840506,
-0.036087096,
-0.045667052,
0.00043364553,
-0.0034496929,
0.011293444,
-0.008950379,
-0.015148792,
-0.0013386626,
-0.018303169,
-0.0009751954,
0.008723212,
-0.027986972,
0.0015090378,
0.037800584,
-0.004095496,
-0.009846066,
0.017576234,
-0.022262365,
0.011137673,
0.0021564637,
-0.023651328,
-0.027234076,
0.012630484,
0.011053296,
-0.048808448,
-0.004825676,
-0.032062996,
0.013344438,
0.021340715,
-0.019523378,
0.0062373565,
-0.008190992,
-0.0139156,
0.0014530574,
-0.0116114775,
0.014305029,
0.002562119,
0.015200716,
0.0045011514,
-0.0034789,
-0.0146035915,
-0.0208734,
-0.010014819,
0.010955939,
-0.020146467,
-0.01231245,
0.014305029,
-0.0020785779,
0.016511794,
0.00401761,
-0.0018432977,
0.00049855036,
-0.006996743,
0.025793187,
0.019536361,
-0.007522472,
0.00063971843,
0.018484902,
-0.0027795502,
-0.022677755,
0.015979575,
-0.006970781,
0.0067371237,
-0.0066787093,
0.017018052,
0.018965198,
-0.0076068486,
0.033101473,
0.020445028,
-0.02180803,
-0.020899363,
0.018705579,
-0.011598497,
-0.027104266,
-0.02206765,
-0.008891964,
0.00051153137,
0.015006002,
-0.0065164473,
0.006363921,
0.009391732,
0.026143674,
0.007184967,
-0.0023414425,
0.010521077,
0.023521518,
-0.01845894,
0.009080188,
0.009742218,
0.0053449147,
0.013435304,
-0.0050950306,
0.010767715,
0.0011050052,
0.034062065,
0.013448285,
-0.03930638,
-0.01699209,
0.010916996,
-0.01551226,
-0.0052215955,
-0.019873865,
0.016641604,
0.022690736,
0.00481594,
0.0073926626,
0.007236891,
-0.022431117,
0.015018983,
-0.012675918,
-0.028350439,
0.041694876,
-0.009080188,
0.028532173,
0.013694923,
-0.0031073198,
0.0027957766,
0.005435781,
0.013487228,
-0.0062276204,
-0.0043129274,
0.008729703,
0.012046341,
-0.019406551,
-0.0017459405,
-0.010391267,
-0.0074640578,
0.015603126,
-0.011170125,
0.003491881,
-0.0115271015,
-0.025390778,
0.0069772718,
0.011079258,
-0.020120503,
-0.010280929,
-0.034944773,
0.008541479,
0.024845578,
-0.019159913,
0.010929977,
-0.0025929487,
-0.0021694447,
-0.0011666648,
0.009794142,
0.013039385,
-0.0022814055,
0.005228086,
-0.01899116,
0.029259106,
-0.0003196564,
0.002768192,
0.006717652,
0.0066787093,
0.040318895,
-0.021457544,
-0.0050950306,
-0.001953636,
-0.004854883,
0.013260061,
0.030712975,
0.0044881706,
0.021444563,
-0.0068474617,
0.009703276,
-0.00019745273,
-0.025494626,
-0.01444782,
0.02047099,
-0.051923882,
-0.003582748,
-0.0045530754,
0.018484902,
0.0062827896,
0.01966617,
-0.019289723,
-0.028194668,
-0.01552524,
0.021587353,
-0.0025897035,
-0.025053272,
-0.015862746,
-0.0030115852,
0.025481645,
-0.024547014,
0.002317103,
-0.0307649,
-0.0056240056,
0.017446425,
0.01271486,
0.011520611,
-0.63388675,
-0.034477457,
0.011656911,
-0.01191653,
0.0021580863,
0.040344857,
0.007652282,
-0.015291583,
-0.0278312,
0.030609127,
-0.040760245,
0.024131624,
0.024637882,
-0.0069642905,
-0.0085025355,
-0.0492498,
-0.004403794,
-0.021418601,
0.043564137,
0.007970315,
0.005526648,
-0.01176725,
-0.022236401,
0.0035178429,
0.0005995586,
0.025637416,
0.043278556,
-0.009813613,
-0.0015341884,
0.02606579,
-0.025507607,
0.025196064,
-0.01858875,
0.006058868,
0.058985528,
-0.005672684,
0.0054552527,
0.037021726,
0.0100278,
0.038579445,
0.008684269,
0.0019228063,
0.019198855,
0.019497417,
-0.030219698,
0.022599868,
0.016252175,
0.0028785302,
0.021003209,
-0.0098525565,
-0.019289723,
0.004825676,
-0.029804308,
-0.016771413,
0.0052410667,
-0.0045952634,
0.024196528,
-0.013591076,
0.014136276,
-0.015161773,
0.00021844539,
0.036476526,
-0.008625855,
-0.012429279,
0.009132112,
0.024923462,
-0.009411204,
-0.0071914573,
0.008547969,
0.012734332,
0.003217658,
0.022496022,
-0.0052345763,
0.024819614,
0.024572976,
0.043693945,
-0.0025767225,
0.01618727,
0.021833992,
0.029726421,
0.006970781,
-0.008496045,
-0.036164984,
0.008229936,
0.024105662,
-0.029544689,
-0.027857162,
0.02382008,
-0.014123295,
-0.007918392,
0.016291117,
0.016317079,
-0.017498348,
-0.051300794,
-0.01618727,
0.012980971,
0.0017021297,
0.033257246,
0.007009724,
-0.022807565,
-0.022911413,
-0.018147396,
0.008509026,
0.006010189,
0.0031592436,
0.00843114,
-0.014525706,
0.0017848834,
0.021379659,
-0.019030102,
-0.014772344,
0.014837249,
-0.011312916,
-0.009904481,
-0.02741581,
-0.02139264,
-0.004841902,
-0.014954078,
-0.021743124,
-0.04252566,
0.020587819,
-0.016524775,
0.0045693014,
-0.0065651257,
0.046316102,
-0.008651816,
-0.0059972084,
-0.010676848,
0.005247557,
-0.018887311,
0.011325897,
-0.021444563,
-0.0029109826,
-0.030271623,
0.019419532,
-0.009820104,
0.0046471874,
-0.0027503432,
0.022924393,
-0.013260061,
-0.0313101,
0.004910052,
0.011669892,
0.0014944342,
-0.008840041,
-0.021353696,
-0.01258505,
-0.010527567,
0.012565579,
-0.0000015766682,
0.022392174,
-0.0018514108,
-0.0098006325,
0.01858875,
0.026273483,
-0.011728306,
-0.0000049692776,
-0.004871109,
0.0131497225,
-0.029622573,
-0.00049327686,
0.02581915,
-0.0003005906,
-0.005607779,
-0.035801515,
-0.024547014,
-0.0043843226,
0.014473782,
-0.0012323809,
-0.026844647,
0.0028477004,
-0.018264225,
-0.013396361,
0.011799702,
0.00037482553,
0.0047834874,
0.006234111,
-0.0018124679,
0.0024923463,
-0.016888242,
-0.0054098195,
-0.005419555,
-0.017809892,
-0.0115271015,
0.033828408,
0.008995812,
0.032088958,
0.0037255385,
0.007853487,
0.0068409713,
-0.014071371,
0.031777415,
-0.026740799,
0.03304955,
-0.005555855,
-0.031907223,
0.017952682,
0.006451542,
0.012662937,
0.02957065,
0.022496022,
-0.02767543,
-0.016563717,
0.001156929,
0.030661052,
-0.03214088,
-0.002609175,
-0.02863602,
-0.03546401,
-0.010598962,
0.008671288,
0.00023041222,
-0.012539618,
-0.006571616,
-0.004053308,
-0.011001373,
-0.006260073,
0.0062373565,
-0.012916066,
-0.02448211,
0.007184967,
0.026273483,
0.022846507,
0.0017719024,
0.009106151,
-0.002472875,
0.010579491,
-0.0016826583,
-0.00067785004,
-0.008281859,
0.0067306333,
0.032348577,
0.004108477,
-0.0066527473,
0.010365305,
0.0043680966,
0.0011658533,
-0.017706044,
0.023184013,
-0.00037137745,
-0.002437177,
0.0142790675,
-0.00026022788,
0.01431801,
0.0026318918,
-0.021288792,
0.037670776,
-0.012656446,
-0.010358814,
0.011617969,
-0.015213697,
-0.0019698623,
-0.0001533377,
-0.009839576,
0.028817754,
-0.03105048,
-0.0002067828,
0.02996008,
0.037800584,
0.00012139235,
0.0082623875,
-0.010456172,
-0.0077691106,
-0.005124238,
-0.0034237308,
-0.008937398,
-0.005821965,
0.008677779,
-0.013006932,
-0.010534057,
-0.037021726,
-0.008768645,
0.0077691106,
-0.047069,
0.017368538,
0.005565591,
-0.011468687,
0.018549807,
0.02515712,
0.027623504,
-0.0034496929,
-0.023923928,
0.022755641,
0.03452938,
-0.0072953054,
-0.008632345,
-0.015603126,
-0.020029638,
0.007821035,
0.006386637,
0.016745452,
0.0031170554,
0.0041506654,
0.0037547457,
0.007775601,
-0.00494575,
0.002055861,
0.0041409293,
0.015732937,
-0.018368073,
-0.0073407385,
-0.0058252104,
-0.0083986875,
0.0002902464,
0.016122365,
0.02448211,
-0.0059972084,
-0.009859047,
-0.008268878,
-0.023716234,
0.013604057,
-0.016044479,
0.009385241,
-0.021353696,
-0.0059874724,
-0.0014173597,
0.025676358,
0.0074316054,
0.0023674045,
0.014058391,
-0.00909966,
-0.039955426,
-0.022405155,
0.0015520373,
0.013630019,
0.020432048,
-0.023482576,
0.019406551,
0.020652724,
0.004228551,
-0.016537756,
0.0036476527,
-0.0021694447,
-0.01565505,
0.008333783,
0.019757036,
-0.007236891,
0.007074629,
0.004189608,
0.027909087,
0.01377281,
-0.031803377,
-0.011410273,
0.002627024,
-0.026818685,
0.008762155,
0.006217885,
0.044862233,
0.011429745,
-0.006191923,
0.019328665,
0.036424603,
-0.006058868,
-0.0051988787,
-0.0139545435,
0.023456613,
0.00047177714,
0.0068409713,
0.015317545,
-0.019821942,
0.009794142,
-0.0012072303,
0.009768181,
-0.009794142,
0.016888242,
0.01966617,
0.0070876097,
0.0043421346,
-0.013058856,
-0.004773752,
-0.0067630857,
0.01457763,
-0.020016655,
-0.018692598,
-0.011760759,
-0.026455218,
0.0056661936,
-0.0142271435,
0.022158517,
-0.018069511,
0.00842465,
-0.00870374,
0.003855348,
-0.0018368074,
-0.0030229434,
-0.021769088,
0.0005792758,
0.0017118654,
-0.018225282,
-0.015070907,
-0.008476574,
-0.010339343,
-0.01818634,
-0.01926376,
0.027909087,
-0.00909966,
-0.04561513,
0.003641162,
0.049717117,
0.026507141,
-0.0005387103,
-0.011222049,
0.0051729167,
0.015096868,
-0.005958265,
-0.024949426,
0.009255432,
-0.01470744,
0.0238071,
-0.008807588,
-0.011559554,
-0.0055071767,
-0.004705602,
0.013837715,
0.003439957,
-0.016966129,
0.013422323,
0.013565114,
0.0028298516,
0.015018983,
0.014590611,
0.016485833,
0.0021402375,
0.0044102846,
-0.009443656,
-0.026546083,
-0.03598325,
-0.013539152,
-0.010469153,
-0.026662912,
0.010916996,
0.0115271015,
-0.013357419,
-0.013052366,
0.008100125,
-0.009125622,
-0.0018595239,
-0.00093706377,
0.004523868,
0.022002745,
0.0022165007,
0.01844596,
0.0014141145,
0.003384788,
0.017212767,
-0.034451496,
0.005980982,
0.010423719,
-0.02863602,
0.007905411,
0.016667565,
-0.013552133,
-0.018640673,
-0.0094761085,
-0.0116114775,
0.03922849,
-0.0021110303,
0.011845135,
-0.007840506,
0.001141514,
0.0060815844,
0.0050074095,
0.016511794,
-0.010521077,
0.0048581283,
0.012630484,
0.020665705,
-0.03211492,
-0.0032533556,
-0.034010142,
-0.004403794,
0.013058856,
0.0139026195,
-0.03214088,
0.0036087097,
0.0240797,
-0.0051729167,
-0.01966617,
-0.012896594,
-0.029882194,
0.00949558,
-0.00856095,
0.02796101,
0.020587819,
0.03600921,
0.01149465,
0.023742195,
0.03868329,
-0.0020331445,
0.009683804,
-0.009586447,
0.015096868,
-0.029726421,
0.012818708,
-0.011546573,
0.01913395,
0.02702638,
-0.00015810416,
0.0063087516,
0.021782069,
-0.0021872935,
0.00010699159,
0.030738939,
-0.039617922,
-0.036995765,
0.010891034,
-0.0065878425,
0.02915526,
-0.055143163,
0.011728306,
0.04039678,
0.013006932,
-0.0061594704,
-0.0030570186,
0.021976782,
-0.017031033,
0.026130693,
0.014863211,
-0.008593403,
-0.009910971,
-0.017225748,
0.011832154,
-0.01753729,
0.016122365,
-0.014759364,
0.0336986,
-0.0051858975,
-0.030193737,
0.009787652,
0.0108780535,
-0.02915526,
-0.012091774,
-0.026312428,
0.0020883137,
-0.007386172,
-0.002566987,
0.0012388714,
-0.021029172,
0.0005817097,
0.0110143535,
-0.023794118,
0.026662912,
-0.003761236,
-0.011929512,
0.014655516,
-0.007282324,
0.033283208,
-0.020535896,
0.025351835,
0.00722391,
0.005942039,
-0.018978179,
-0.004111722,
0.0024988367,
0.0039429697,
0.032997627,
0.013655981,
-0.0018627692,
-0.0025231761,
0.0018968442,
0.014642535,
-0.0015163396,
-0.020133484,
0.017147861,
-0.012987461,
0.004559566,
0.0029515482,
-0.017095938,
-0.030141814,
0.010547038,
0.00044906043,
0.024014795,
-0.008742684,
-0.048886333,
-0.011708835,
0.015849765,
-0.0139545435,
0.0016266778,
0.00735372,
0.0053449147,
-0.0017426952,
-0.0036703693,
-0.005056088,
0.0047283187,
-0.0059323036,
0.04452473,
-0.0318553,
0.011754269,
0.020886382,
-0.018017586,
-0.015239659,
-0.013565114,
0.007652282,
0.03691788,
-0.02606579,
-0.026740799,
0.011481668,
-0.00290936,
0.014006467,
-0.00033446282,
0.0025604963,
-0.029544689,
-0.023106128,
-0.010819639,
0.022560926,
0.018757502,
0.018939236,
0.008593403,
-0.031543758,
-0.002300877,
-0.034451496,
-0.031491835,
0.014019448,
-0.042110268,
-0.005458498,
-0.0013897751,
0.036424603,
0.01578486,
0.017991625,
-0.006178942,
-0.014486763,
0.01886135,
-0.00950856,
0.008976341,
0.006247092,
0.001023874,
-0.033231284,
0.011455706,
0.0009646484,
-0.030816823,
0.0112025775,
-0.026156655,
-0.023222955,
-0.012241055,
-0.00049530517,
0.010092705,
0.0062049036,
-0.017939702,
-0.00007748017,
0.001726469,
0.025650397,
-0.0012461732,
-0.013032895,
0.033231284,
-0.026520122,
0.007282324,
0.0027357396,
-0.0041571558,
-0.021029172,
0.0024566487,
0.004845147,
0.002115898,
-0.023923928,
-0.001212098,
-0.009651352,
-0.0017053749,
-0.0020915589,
0.007918392,
-0.017744986,
-0.037696738,
-0.020717628,
0.0065391636,
-0.0028168706,
-0.008184502,
-0.017056994,
0.012351394,
-0.01592765,
-0.0010847223,
-0.030557204,
-0.0006105113,
-0.010806657,
-0.029596612,
-0.064697154,
0.009164565,
-0.012481203,
0.025105197,
0.024404224,
-0.020432048,
-0.015434374,
-0.017290652,
-0.04322663,
-0.016628623,
0.028999487,
0.012903084,
0.0033750522,
0.009969385,
-0.010527567,
-0.0024615165,
0.0049522403,
0.018303169,
0.010079724,
0.0012761917,
0.00026854384,
-0.008197483,
0.021769088,
0.0017621667,
-0.011540082,
-0.015135812,
0.023430651,
-0.0005650779,
-0.023599405,
0.021068115,
-0.027104266,
0.055766247,
-0.019432513,
0.023846043,
0.00870374,
0.016420927,
0.03546401,
-0.024092682,
0.0009476108,
-0.0065229377,
0.010099195,
-0.007262853,
0.008982832,
-0.00017554733,
0.012033359,
0.016122365,
-0.011579026,
-0.012831689,
0.012163169,
-0.0031608662,
0.022262365,
0.006029661,
0.024261434,
0.014136276,
0.01457763,
0.009515051,
-0.010929977,
-0.027285999,
-0.0055201575,
0.00534816,
-0.000632011,
-0.031725492,
-0.017420461,
-0.014811287,
-0.0025686095,
-0.026844647,
0.003097584,
-0.0047445446,
-0.009651352,
-0.024702787,
0.012870632,
-0.0020445029,
-0.016732471,
-0.010547038,
0.0008689137,
-0.00021905388,
-0.0103133805,
0.0009265168,
-0.0051566903,
-0.024508072,
-0.001086345,
-0.019185875,
-0.0020331445,
-0.0012283244,
-0.0014092466,
-0.024521053,
-0.00856095,
0.0016274891,
0.17041418,
-0.02528693,
-0.009197017,
-0.01163095,
0.015758898,
-0.007814544,
0.025222026,
0.0065326733,
-0.00749651,
0.00018355904,
-0.0032841854,
0.0071135717,
-0.009781161,
0.004001384,
0.034036104,
-0.029804308,
-0.03639864,
-0.015343507,
-0.03159568,
-0.02221044,
0.019341646,
-0.013889638,
-0.008651816,
-0.017368538,
0.028999487,
-0.0012916066,
-0.03837175,
0.00073342485,
0.014486763,
-0.017939702,
-0.02822063,
0.0051566903,
-0.0021872935,
0.0040046293,
0.01431801,
0.012267017,
0.0051826523,
-0.007983297,
-0.01886135,
-0.01097541,
-0.00461798,
0.0203282,
0.00037786792,
0.015719956,
0.010709301,
0.019821942,
0.020042619,
0.001945523,
0.0002691523,
-0.009450146,
-0.036476526,
0.022950355,
0.0044070394,
0.04309682,
-0.013837715,
-0.009248941,
0.01594063,
-0.007639301,
-0.028064858,
0.023508538,
-0.008320802,
0.016330061,
-0.026662912,
0.02139264,
-0.010112176,
0.029674498,
-0.017589215,
-0.000787377,
-0.007022705,
-0.0045043966,
0.00454334,
-0.003123546,
-0.014941097,
0.005984227,
0.0038066695,
-0.022963336,
0.02382008,
0.00828835,
0.010008328,
0.029648537,
0.030609127,
-0.001159363,
-0.026468199,
0.012838179,
-0.010508096,
-0.039955426,
0.023794118,
0.039903503,
-0.018342111,
-0.013733867,
0.015161773,
-0.014149258,
0.005059333,
-0.0076457914,
-0.009080188,
-0.009125622,
-0.005646722,
0.021003209,
-0.019757036,
0.017095938,
-0.03689192,
0.056545105,
-0.022911413,
0.0095799565,
0.007425115,
-0.00014867267,
-0.0016842809,
0.010443191,
-0.000002723912,
0.0076977154,
0.006406109,
-0.019523378,
-0.0062081493,
-0.0070291953,
0.0049782023,
0.024196528,
0.021444563,
-0.01871856,
0.01927674,
-0.0022181233,
-0.0027406074,
-0.0307649,
0.005672684,
0.044732425,
-0.0065196925,
-0.002258689,
-0.02529991,
0.007846996,
0.00033689674,
-0.031517796,
0.0059030964,
-0.0071784765,
0.017173823,
0.01752431,
0.0027535884,
-0.022119574,
0.0112025775,
0.00031052914,
-0.040215045,
0.026403293,
-0.030583166,
-0.013422323,
0.006286035,
0.023884986,
0.000398962,
-0.033750523,
0.025884055,
0.008301331,
-0.016161308,
-0.017238729,
-0.007866468,
-0.010404248,
-0.008911436,
0.0011561177,
0.038190015,
-0.032738008,
-0.012091774,
-0.018965198,
0.015823802,
0.014746382,
-0.01726469,
0.020172428,
0.007146024,
-0.0155771645,
-0.010287419,
-0.008489555,
-0.16127558,
-0.020393105,
0.0064028637,
-0.039072722,
0.006594333,
0.029596612,
0.012279998,
-0.017031033,
0.0025101951,
0.020276276,
0.017693063,
-0.01551226,
-0.032062996,
-0.01137133,
0.013552133,
0.0040111197,
0.008943888,
0.051326755,
0.026169635,
0.016356023,
-0.00250695,
0.002317103,
0.028142743,
0.014006467,
-0.0005780588,
0.0024014795,
0.015953612,
-0.0013881525,
-0.01191004,
0.0014214163,
-0.017147861,
0.0013337947,
0.019886846,
0.009313846,
0.017913738,
-0.005951775,
-0.0008279425,
0.021288792,
-0.013331456,
0.011085749,
0.012273507,
0.010001837,
0.003800179,
-0.00448168,
0.0101770805,
0.022794584,
0.010676848,
-0.008463592,
0.018887311,
0.007522472,
0.026662912,
-0.0070032333,
0.019497417,
0.014305029,
0.028947564,
0.0066787093,
0.014902154,
0.009787652,
-0.013552133,
-0.009722747,
0.009735728,
-0.019834923,
0.041539107,
-0.0025767225,
-0.00028395874,
-0.020445028,
0.0023252163,
0.0080417115,
-0.037099615,
-0.008320802,
-0.017744986,
-0.011222049,
0.0141882,
-0.014136276,
0.018575769,
0.0064223353,
-0.011819174,
0.006665728,
-0.010112176,
0.00588687,
-0.0018027322,
-0.0004875977,
-0.034321684,
-0.012864142,
-0.007730168,
0.0061367536,
0.00029004356,
0.016771413,
-0.005536384,
-0.009307356,
0.0065910877,
0.0007472171,
0.007736658,
0.0027146454,
0.025390778,
0.03182934,
0.0032825628,
-0.0073017958,
-0.00039612243,
0.01683632,
0.0141882,
-0.011488158,
-0.018004606,
-0.008216954,
0.045121852,
-0.0012753804,
-0.0058771344,
0.03276397,
0.06386638,
-0.0055493647,
-0.012507165,
0.0022213685,
0.002468007,
0.0042967014,
0.00331177,
0.010183571,
-0.015538221,
0.00029876514,
-0.0032533556,
-0.0057635508,
0.057064347,
-0.0062146396,
-0.0032695818,
0.013526171,
-0.018705579,
-0.026585028,
-0.12773275,
-0.024183547,
0.0014846985,
-0.0058803796,
-0.026325408,
0.026662912,
-0.010079724,
0.024443166,
-0.038345788,
0.038501557,
-0.021885917,
-0.002094804,
-0.010806657,
-0.021600334,
0.021872936,
-0.0005914455,
0.007146024,
0.01991281,
-0.0278312,
0.040552553,
-0.0009792519,
-0.0030067172,
-0.007814544,
-0.023910947,
-0.010715791,
-0.0005427668,
-0.037878472,
0.0041311937,
0.014434839,
0.012260526,
0.0108261295,
-0.018017586,
0.0139545435,
0.009443656,
-0.0071070814,
-0.011358349,
0.019523378,
-0.027130228,
0.024715768,
-0.015161773,
0.0021824257,
0.011364839,
0.011040315,
0.008145559,
0.0032793176,
-0.019237798,
-0.012916066,
0.0122280745,
0.022924393,
-0.016875261,
-0.037670776,
-0.026844647,
-0.0075354534,
-0.016654585,
0.0034139953,
-0.016732471,
0.008872493,
0.013720886,
-0.013733867,
0.004426511,
0.014421858,
0.011799702,
-0.034088027,
-0.00013011394,
0.005205369,
-0.012461731,
-0.0145516675,
-0.031206252,
0.023755176,
-0.030349508,
-0.0053351787,
0.024131624,
0.0007816978,
0.0030407922,
-0.03491881,
0.01271486,
-0.01485023,
-0.014785325,
0.022275345,
-0.019808961,
-0.007730168,
-0.012993951,
0.03214088,
-0.02809082,
0.021717163,
0.021885917,
-0.0008632345,
-0.014460801,
-0.005698646,
-0.014538687,
0.005176162,
0.058673985,
-0.0062406017,
-0.020652724,
-0.0110662775,
0.0072563626,
0.010605453,
0.0013565114,
0.02285949,
0.013305495,
-0.0009565352,
-0.015875727,
-0.053845067,
0.006529428,
-0.010852091,
-0.006552145,
0.013733867,
-0.015148792,
0.009404713,
0.004040327,
-0.01670651,
0.0051664263,
0.009456637,
0.0052929907,
-0.012773274,
-0.00025840243,
-0.014110315,
-0.014902154,
0.030816823,
-0.011020844,
0.005205369,
0.025481645,
0.021717163,
-0.015213697,
0.0096124085,
0.0030683768,
-0.009768181,
-0.015732937,
-0.01069632,
0.023599405,
-0.010508096,
0.0021272565,
0.008736193,
-0.046601683,
-0.0035924835,
0.0142271435,
0.0037125575,
-0.02328786,
0.0067241425,
0.009197017,
0.011332387,
0.024040757,
-0.04738054,
-0.022716697,
0.0113388775,
-0.006672219,
0.026974456,
0.015148792,
-0.038579445,
0.0064190896,
0.009761689,
-0.0053741215,
0.045407433,
0.02045801,
0.004361606,
-0.023196993,
-0.017809892,
-0.022664774,
-0.017147861,
-0.007976806,
0.012611013,
-0.015888708,
0.029103335,
0.014305029,
0.0012737577,
0.0025994394,
-0.017342577,
-0.008911436,
-0.0068020285,
-0.0010376663,
0.009404713,
-0.033828408,
-0.041928533,
-0.01499302,
0.010916996,
0.016693527,
0.017368538,
-0.0053741215,
-0.013993486,
0.0003151942,
-0.025403759,
0.024572976,
0.025910016,
-0.0007699338,
0.008203973,
0.027753314,
0.02767543,
-0.012390336,
-0.0203282,
-0.0043908134,
0.007885939,
-0.0025556285,
-0.01873154,
0.009774671,
0.008677779,
0.011170125,
0.0103004,
0.02285949,
-0.019198855,
0.016966129,
-0.019302703,
0.028350439,
-0.013409343,
0.008236426,
0.006931838,
-0.011248011,
-0.019419532,
0.04390164,
-0.01096892,
-0.020587819,
0.0052345763,
-0.0076263202,
0.019185875,
0.012202112,
0.0045952634,
-0.007885939,
-0.011929512,
0.0043810774,
0.014032429,
-0.010430209,
-0.0065359185,
0.054260455,
0.0113388775,
0.0027503432,
0.011209068,
-0.029856231,
0.025105197,
-0.017368538,
0.03156972,
-0.025611455,
0.007944354,
-0.013630019,
0.023456613,
0.0050495975,
-0.047302656,
-0.007100591,
0.008106616,
-0.008677779,
0.008522007,
0.035022657,
-0.006578107,
0.0884783,
-0.0005224841,
-0.021730144,
0.017939702,
-0.018082492,
0.037618853,
0.0085025355,
0.017965663,
-0.01404541,
-0.036087096,
0.03343898,
-0.040500626,
0.018510863,
-0.030297585,
-0.03276397,
0.0066040684,
-0.00775613,
0.007691225,
0.017822873,
-0.000690831,
0.010378285,
-0.0048354114,
0.0037287837,
0.020938305,
-0.03517843,
0.0069123665,
0.020704648,
0.0033653167,
-0.018796446,
-0.007197948,
0.00989799,
-0.0015293206,
-0.054364305,
-0.0022213685,
-0.001381662,
0.0053059715,
-0.005445517,
-0.02555953,
0.025105197,
-0.0081260875,
0.006260073,
0.000066476765,
0.0066170497,
-0.024144605,
0.021587353,
-0.01311078,
-0.016498813,
-0.009644861,
0.006607314
] |
The invertebrate's innate immune system was reported to show some form of adaptive features, termed trained immunity. However, the memory characteristics of innate immune system and the mechanisms behind such phenomena remain unclear. Using the invertebrate model Artemia, we verified the possibility or impossibility of trained immunity, examining the presence or absence of enduring memory against homologous and heterologous antigens (Vibrio spp.) during a transgenerational study. We also determined the mechanisms behind such phenomenon. Our results showed the occurrence of memory and partial discrimination in Artemia's immune system, as manifested by increased resistance, for three successive generations, | [
-0.007410334,
-0.00774534,
-0.0046364837,
-0.0033433605,
-0.008911161,
0.017514117,
-0.0052126944,
-0.017232712,
-0.017929524,
-0.02710869,
0.013581146,
0.00993628,
0.0048542377,
-0.017058508,
0.0039497213,
0.010753695,
0.04301478,
0.025085254,
0.000082914,
-0.00881736,
-0.01993956,
0.015839087,
0.015142274,
-0.0035309638,
-0.0043952796,
-0.0055041495,
0.0135878455,
-0.041835558,
-0.010653193,
0.00007542871,
0.031329766,
-0.0027269493,
-0.028837321,
-0.021225983,
-0.030793756,
-0.025138855,
0.024147237,
-0.026210874,
0.022887614,
0.02822091,
0.007879343,
0.011959717,
0.00024267001,
-0.00044639557,
-0.0063651153,
0.008669957,
-0.011262904,
0.0010200934,
-0.009199266,
0.0035711646,
0.035912648,
-0.0110686,
-0.0032160582,
0.014472262,
-0.0048843883,
-0.0069949264,
0.003651566,
0.010405288,
0.023664828,
-0.041781954,
-0.005035141,
0.010733594,
-0.009433771,
0.012669929,
-0.015128873,
0.0127369305,
-0.013534245,
-0.0007252881,
-0.014244458,
0.019778758,
0.034626227,
0.030070145,
-0.0023165669,
-0.0063416646,
0.040656336,
-0.010927898,
-0.01940355,
0.00830815,
-0.0134203425,
0.0004095449,
-0.0020803877,
-0.038565896,
-0.012824032,
0.0017889324,
0.02371843,
0.014525862,
0.02491105,
0.0061741616,
0.016870905,
-0.002708524,
0.005899457,
0.013748649,
0.009092065,
0.006361765,
-0.0075845374,
0.010271286,
-0.0071088285,
0.030150546,
-0.028301312,
-0.00828135,
-0.02875692,
-0.013179138,
-0.014418661,
-0.024509043,
-0.018586136,
0.009286368,
0.015504081,
0.021279585,
0.008904461,
-0.014110455,
-0.015798885,
0.028006507,
0.007350033,
-0.067108415,
0.00304018,
0.017004907,
0.0037386676,
-0.009561073,
-0.0070351274,
-0.015785486,
0.0063148644,
0.016401896,
-0.0017922824,
-0.006753722,
0.038753502,
0.038539097,
-0.012629729,
0.0067503722,
-0.004693435,
0.00044848936,
0.0045560827,
0.026050072,
0.0004166638,
-0.0030485552,
-0.03583225,
0.012971435,
-0.019631356,
0.0034505625,
0.010351688,
-0.01380225,
0.019068545,
0.014110455,
-0.01988596,
-0.0080803465,
0.00938017,
0.005008341,
0.021078581,
0.039396714,
-0.02162799,
0.01992616,
-0.015155674,
-0.036582664,
-0.022820612,
-0.016509099,
0.023490625,
0.024013234,
-0.013788849,
0.010813995,
-0.030123744,
-0.008267949,
0.0008961412,
-0.0038626199,
0.021936197,
-0.010599592,
-0.0012822357,
0.025661465,
-0.0053868974,
0.0035778647,
0.0016038415,
-0.010150684,
-0.009159066,
0.03264299,
-0.030177345,
0.026117073,
-0.015102074,
0.012006617,
0.009601274,
0.0063651153,
0.0013433743,
-0.025299657,
0.008991563,
-0.008133947,
0.0165627,
-0.024214238,
-0.00036557537,
-0.0038257693,
0.0039195707,
0.0005456411,
0.010291386,
-0.015906088,
0.0077051395,
0.020529171,
-0.008803959,
0.0037989686,
-0.64364046,
-0.0332326,
0.022257803,
-0.013192539,
0.03811029,
0.016803904,
0.0057152035,
-0.036663063,
-0.01709871,
0.005752054,
-0.019175747,
-0.0021892646,
-0.0062679634,
-0.026720084,
-0.023061818,
-0.017527517,
0.0059966086,
-0.008495754,
0.025098654,
0.0074974354,
0.008556055,
-0.008743658,
0.006693421,
0.021212583,
-0.007128929,
-0.0034120367,
-0.0034505625,
-0.018157328,
-0.016710103,
0.03652906,
-0.016334895,
0.032830592,
0.0059363074,
0.01608029,
0.036904268,
-0.005272995,
-0.006797273,
0.028569316,
-0.006351715,
0.023008216,
-0.015343278,
-0.0042813774,
0.012080318,
0.020756975,
0.008790559,
0.027390096,
0.007524236,
0.014525862,
0.018009925,
-0.029748539,
0.008582856,
0.008020045,
-0.021346586,
0.010110483,
0.014030054,
-0.023597827,
0.001689268,
-0.01774192,
-0.0060602594,
0.0039028206,
0.0014983146,
-0.0037989686,
0.014740267,
-0.03540344,
-0.03760108,
0.024160637,
-0.03529624,
0.01764812,
-0.0031892578,
-0.023329822,
0.0033299602,
0.026867487,
-0.013735249,
0.0051624435,
0.0010896072,
0.034331422,
-0.0035678146,
-0.006361765,
0.0048508877,
0.030686555,
-0.010753695,
-0.010465589,
-0.01436506,
-0.0034639626,
0.019805558,
-0.019095346,
-0.0014815642,
0.025661465,
-0.005182544,
-0.011812313,
0.020529171,
0.021373387,
-0.016495699,
-0.03154417,
-0.0221104,
0.03593945,
-0.018063527,
-0.014874269,
-0.0018140578,
-0.02705509,
-0.010860897,
-0.015624682,
0.029534135,
-0.0024539195,
0.009313169,
-0.0035008134,
-0.018411933,
0.0035142135,
0.05140333,
-0.008884361,
0.0166163,
0.01164481,
0.0005946358,
-0.000038499526,
-0.0020418619,
-0.019229349,
0.03191938,
0.023504024,
0.00049999653,
-0.029212529,
0.01941695,
0.0031105313,
0.005128943,
0.01327294,
0.008609655,
0.010921198,
-0.007872642,
-0.012522526,
-0.008100446,
-0.007450535,
0.02097138,
-0.0025276206,
-0.002050237,
-0.005145693,
0.028569316,
0.017822322,
0.016844105,
0.011142301,
0.020783776,
-0.0082545495,
0.0022830663,
0.0042981277,
-0.021641392,
-0.02048897,
-0.035912648,
0.0066532204,
-0.0010653193,
-0.00028978023,
-0.004482381,
0.0014882644,
0.015664883,
-0.000551085,
-0.016428698,
0.0012780481,
0.018050127,
-0.007678339,
-0.017889323,
-0.03095456,
0.002765475,
-0.000053417763,
-0.0060971105,
0.009983181,
-0.0050552413,
0.022338204,
-0.0031473818,
-0.008917862,
0.004576183,
0.00037185673,
-0.009159066,
-0.035751846,
0.011142301,
-0.020180766,
0.0012085343,
0.025674865,
0.0023383424,
0.018894343,
-0.025875868,
-0.0049513895,
-0.001245385,
-0.0063651153,
-0.0038994704,
-0.013775449,
0.0051657935,
-0.033366602,
0.040173925,
-0.003973172,
0.025527462,
0.02929293,
0.02371843,
0.05250215,
0.006033459,
0.006468967,
-0.006418716,
0.0068173734,
-0.010076982,
-0.020730175,
0.023678228,
0.0050485414,
0.011778813,
0.041245945,
-0.0016926181,
-0.02988254,
-0.00061934243,
-0.021038381,
0.010532591,
-0.0061038104,
0.008435452,
-0.0070083267,
0.023571026,
0.00025041704,
0.009192566,
-0.0040401733,
0.006736972,
-0.024629645,
0.019711757,
0.016495699,
-0.0043282784,
0.006921225,
0.0059530577,
-0.00151674,
-0.010907797,
-0.00066959334,
0.0139228515,
-0.0062445127,
-0.019738557,
0.011765413,
-0.0047202352,
0.0166163,
-0.010257886,
-0.023638027,
0.015839087,
0.0015720159,
0.0043550786,
0.007504136,
0.036957867,
0.01877374,
0.0100300815,
0.0023885933,
0.019202547,
0.021962997,
0.017460516,
0.0074371346,
-0.0064522168,
-0.0020803877,
0.030927759,
0.017822322,
0.029748539,
0.0031691573,
-0.020220965,
-0.001053594,
-0.015450479,
-0.0166029,
-0.028596118,
-0.0018174079,
-0.007892743,
-0.016227694,
0.0042780275,
-0.0016917806,
0.02043537,
0.02990934,
0.022713412,
0.0061038104,
0.0015360027,
0.0011247828,
0.018371733,
-0.010820696,
-0.015142274,
0.0010301436,
-0.012073618,
-0.0033852363,
-0.018076926,
-0.023785431,
-0.0027185741,
-0.017473916,
0.010773795,
0.0072093303,
-0.00017347033,
-0.0033567608,
-0.0036817165,
0.0018659837,
-0.032267783,
-0.033849012,
0.027215892,
0.024790449,
0.0070351274,
-0.024200838,
-0.025071854,
0.0016775428,
0.0043316283,
0.016442098,
0.0072562313,
0.017299714,
0.009460571,
0.010827396,
-0.02322262,
0.010143983,
0.036716666,
-0.025835667,
-0.0005263783,
-0.02048897,
-0.0010393563,
-0.0038559197,
-0.021909397,
0.0038927705,
0.002711874,
-0.01165151,
-0.008174147,
-0.015758686,
-0.00829475,
0.00053475343,
0.0043919296,
-0.014405261,
0.008388552,
-0.013721848,
0.016951306,
-0.00021628829,
-0.029748539,
0.01216742,
0.0166163,
0.007571137,
-0.013708448,
-0.031812176,
-0.012917833,
0.0017855823,
0.04872328,
0.005869306,
-0.017272912,
0.01993956,
-0.0165627,
-0.014619664,
-0.0019731857,
-0.011115501,
0.04481041,
-0.018331531,
-0.013909452,
-0.018639738,
0.01490107,
0.00828805,
0.0017520817,
0.018679937,
0.00331991,
-0.0221238,
-0.00330986,
-0.00771854,
0.0042746775,
-0.008087046,
0.02867652,
0.021654792,
0.016200893,
-0.001882734,
0.015919488,
0.0067068213,
0.001773857,
-0.007015027,
0.0006168299,
-0.006013359,
0.01992616,
0.012428725,
-0.0064790174,
-0.02929293,
-0.008904461,
0.015812285,
0.0035309638,
-0.0046096835,
0.0276313,
0.020689974,
0.00193466,
-0.0047369855,
0.0068877246,
-0.006184212,
0.019483952,
-0.0017604568,
0.0008400277,
-0.013621346,
0.028060108,
0.0022545909,
-0.000037583493,
-0.031222565,
0.0072495313,
-0.002872677,
-0.005319896,
0.0066465205,
0.007993245,
0.006760422,
0.00052260945,
-0.026344877,
0.021654792,
0.00045853955,
-0.031758573,
-0.0107067935,
-0.0070820283,
0.00993628,
-0.02824771,
-0.005631452,
-0.009835778,
-0.032750193,
-0.03208018,
-0.010974798,
-0.005638152,
0.015530881,
0.02988254,
-0.02647888,
0.0019815608,
0.016482297,
0.0061540613,
-0.019122146,
0.009668275,
-0.039959524,
0.03529624,
0.013554345,
-0.003983222,
-0.01494127,
-0.0027939505,
-0.00774534,
0.010257886,
0.015879286,
0.008174147,
0.01439186,
-0.003929621,
0.0013819,
0.01768832,
0.036797065,
-0.016401896,
-0.01595969,
0.0042746775,
-0.03551064,
-0.01709871,
-0.02657268,
-0.011484007,
-0.029185727,
-0.022834012,
0.01763472,
-0.0118056135,
-0.023584427,
0.0045058313,
0.00007610919,
0.017527517,
-0.021493988,
0.020730175,
-0.0032730093,
-0.015383478,
0.0077319397,
0.0044421805,
0.0036683164,
0.001546053,
-0.0032378335,
0.012844132,
0.014097055,
-0.020917779,
-0.0013601246,
-0.0005674165,
0.018746939,
-0.022445407,
-0.013045136,
0.005417048,
0.016214292,
-0.005138993,
-0.016281294,
-0.0012830732,
-0.026599482,
-0.0041842256,
0.0009564423,
-0.011182502,
-0.018961344,
0.008375151,
-0.020153964,
0.0026716734,
-0.01719251,
0.040039923,
-0.03529624,
0.00026591105,
0.007309832,
-0.0018894342,
0.007671639,
-0.00055694755,
-0.019229349,
-0.0030720055,
0.023785431,
-0.019189147,
-0.034519024,
-0.01275033,
0.002988254,
0.046820447,
0.01719251,
0.018103728,
-0.010224385,
0.0048977886,
0.013125538,
-0.0030703305,
0.0132461395,
0.0013643121,
0.00248407,
-0.00048910885,
0.0012738606,
0.011544309,
-0.0031323067,
-0.016964708,
-0.0042880774,
0.026184075,
0.017433716,
-0.018827341,
-0.015892688,
-0.019805558,
-0.00996308,
0.015718484,
0.0018994843,
0.005075342,
-0.0049915905,
-0.0045426823,
0.0003787662,
0.012830732,
-0.0036180655,
0.016535899,
-0.0033969614,
0.028596118,
-0.009025063,
0.03687747,
-0.023611227,
0.011309804,
-0.009902779,
-0.0009505797,
-0.010780495,
-0.017983126,
0.017313113,
-0.0089312615,
-0.008690057,
0.008562755,
-0.004221076,
-0.0038961205,
0.0028944523,
-0.00005370566,
-0.018465534,
-0.02097138,
0.002489095,
-0.033447005,
-0.016884305,
-0.014499063,
-0.015236076,
-0.009902779,
-0.0011783838,
-0.017031709,
0.014579464,
-0.030713355,
-0.025581064,
0.022244403,
-0.012100419,
0.033473805,
-0.014847469,
0.019162348,
0.034545824,
0.0073969336,
-0.015544281,
-0.014056854,
0.0051858937,
-0.0019380101,
0.032240983,
-0.00011924122,
-0.004190926,
-0.04813367,
0.025808867,
0.02432144,
0.003207683,
-0.035135437,
0.024482243,
0.004241177,
0.00553095,
-0.008911161,
-0.011939616,
-0.01987256,
0.030016543,
-0.02985574,
-0.004917889,
0.006948026,
0.017621318,
-0.024616245,
0.00940027,
0.003487413,
0.030686555,
0.0110351,
-0.0028592767,
-0.0013090362,
-0.013045136,
0.0016649801,
0.010847496,
0.023638027,
0.030311348,
-0.0017026683,
0.015879286,
0.021319786,
0.014271258,
0.0022880915,
0.006137311,
-0.021065181,
0.035081834,
-0.01817073,
-0.009333269,
0.007899443,
0.022807213,
-0.006860924,
-0.035751846,
-0.008683357,
-0.013460544,
-0.01491447,
0.006927925,
0.014673266,
0.024080236,
0.018197529,
-0.0146866655,
-0.025152255,
-0.009172466,
-0.027497297,
-0.014123855,
-0.024093635,
-0.035885848,
-0.01720591,
0.016870905,
0.007899443,
0.013674947,
-0.021319786,
-0.012676629,
0.0108809965,
0.040013123,
-0.036716666,
0.0107067935,
0.01766152,
0.0021691641,
-0.040066727,
-0.00072989444,
0.0017805572,
-0.017902724,
0.03655586,
-0.028033307,
-0.045507222,
-0.030230947,
0.0028040006,
0.022847414,
-0.01327964,
-0.000815321,
-0.0032244334,
-0.012308123,
0.02375863,
-0.00221774,
0.0010912822,
0.007792241,
-0.010083683,
0.0019949612,
0.022834012,
-0.036287855,
0.005745354,
0.0029916042,
0.005825755,
-0.0017989825,
-0.03936991,
-0.011691712,
-0.013788849,
0.00046063334,
-0.018894343,
-0.026974687,
0.01325954,
-0.032535788,
-0.0026063472,
-0.002876027,
-0.011993217,
-0.021319786,
0.00828805,
-0.0025929469,
0.0025125456,
-0.006231113,
0.000331656,
0.022378406,
0.0044957814,
-0.0016088666,
-0.040173925,
0.015999889,
-0.017085308,
0.037708282,
-0.0036314656,
0.021400187,
-0.0046800347,
0.019215947,
-0.038485497,
-0.010813995,
-0.0029899292,
0.010023382,
0.010941298,
0.009159066,
0.01940355,
0.002479045,
0.013105437,
-0.0034371621,
0.016669901,
-0.026425278,
0.00011065669,
-0.012194221,
0.017246112,
0.01823773,
-0.020663174,
-0.01709871,
0.021426987,
-0.029346531,
0.019591155,
-0.00012897734,
-0.029400133,
0.020019962,
-0.003152407,
0.023597827,
-0.0063148644,
0.0100300815,
0.02437504,
-0.015544281,
-0.026867487,
-0.00029480533,
-0.035108633,
-0.008937961,
0.0013182488,
0.014271258,
0.009674975,
0.023678228,
-0.05030451,
-0.02432144,
0.032803793,
-0.014820668,
0.02591607,
0.011095401,
0.003212708,
0.012891034,
-0.013045136,
-0.03390261,
-0.03985232,
0.005484049,
-0.018586136,
0.023276221,
-0.0034974632,
-0.0072495313,
0.007959744,
-0.013453843,
0.006301464,
-0.037413478,
0.0066967714,
-0.018519135,
0.018854141,
-0.010170784,
0.015169075,
0.0024070186,
0.008703457,
-0.010633092,
0.0020753625,
0.011973117,
-0.021842396,
-0.010117183,
-0.009902779,
0.019751957,
-0.0053801974,
0.027952906,
0.0007696764,
-0.017527517,
0.0033567608,
-0.010398588,
-0.011825714,
-0.011417006,
0.17945604,
-0.015557681,
-0.0040636235,
0.0276045,
-0.017286312,
0.00773864,
0.010941298,
0.0025091954,
0.010465589,
0.000592542,
0.03194618,
-0.0019229348,
0.00012206783,
0.006405316,
0.016107092,
-0.037440278,
-0.017018307,
-0.009165766,
-0.0021808895,
-0.0220702,
0.0012587853,
-0.006592919,
-0.011390206,
-0.01051249,
0.046338037,
0.0052897455,
-0.01437846,
0.010271286,
-0.023155618,
-0.02048897,
-0.024428641,
-0.009239467,
0.025835667,
-0.0067637726,
0.010478989,
0.002219415,
-0.004291428,
-0.00609376,
0.005175844,
-0.010519191,
0.009112165,
0.0007441322,
0.01437846,
-0.014123855,
-0.0055209,
0.043952797,
-0.013132238,
-0.010519191,
-0.0077118394,
-0.003654916,
-0.02544706,
-0.0027319745,
-0.0135878455,
-0.0045192316,
0.013735249,
0.0008969787,
-0.0020653124,
-0.013989853,
0.018746939,
0.026117073,
-0.017259512,
0.018103728,
-0.02038177,
0.033259403,
-0.004921239,
0.045721628,
-0.017004907,
-0.0025544213,
0.00048282748,
-0.016696703,
0.003370161,
-0.018438734,
-0.023142219,
0.0072227307,
-0.03162457,
-0.014472262,
0.018988144,
0.0046197334,
0.015919488,
-0.0017705071,
0.006261263,
0.013353341,
-0.0332326,
0.017071908,
-0.009360069,
-0.017447116,
0.0221506,
0.0033584358,
-0.0074907355,
0.008703457,
0.0014120506,
0.0040167226,
-0.011819013,
0.0004995778,
0.022807213,
0.0025694964,
0.017018307,
-0.0036817165,
0.0050686416,
-0.014592864,
-0.021493988,
0.058317855,
0.025004853,
-0.0047168853,
-0.011584509,
0.031731773,
-0.02706849,
0.028917722,
0.012113819,
-0.0017755321,
0.009460571,
-0.015517481,
0.0038291193,
-0.023088617,
-0.0063249143,
0.016093692,
0.0060971105,
-0.01713891,
0.031838976,
0.019282948,
0.015075273,
-0.01766152,
0.012428725,
0.028033307,
-0.0008098772,
-0.023530826,
-0.047195654,
0.02603667,
0.0031155564,
-0.03194618,
0.0050016404,
-0.01216072,
-0.0021792145,
-0.0035075136,
-0.007953044,
-0.0070418273,
0.008200948,
-0.0028324763,
-0.022472207,
0.0055041495,
0.0034907633,
-0.020743575,
0.016254494,
-0.00035866586,
0.0042344765,
-0.034009814,
0.028515715,
0.018880941,
0.0026046722,
-0.0030385049,
0.020220965,
0.0036281156,
-0.011544309,
0.020770377,
0.013721848,
-0.02379883,
-0.030552553,
-0.0110284,
-0.0012612978,
-0.011329905,
-0.037467077,
-0.0007018377,
0.018117128,
-0.007671639,
-0.019041745,
0.0010770445,
-0.16884306,
-0.0041105244,
0.005249545,
-0.029775338,
0.038860705,
0.00089949125,
0.023490625,
-0.002542696,
-0.013989853,
0.017594518,
0.02824771,
0.0062746634,
-0.01608029,
-0.04258597,
0.005541,
-0.0030736807,
-0.020113764,
0.024710046,
0.008408652,
0.0023014916,
0.02539346,
-0.031195763,
0.0045225816,
-0.023678228,
0.014016653,
0.017567718,
0.0037118671,
-0.0022746911,
0.00033102787,
-0.031812176,
-0.000884416,
-0.013487344,
0.017460516,
-0.0056113517,
0.01989936,
0.0055041495,
0.018706739,
0.0056147017,
-0.0032160582,
0.042746775,
0.013735249,
0.021922797,
0.012683329,
-0.014231058,
-0.01775532,
-0.0016951307,
-0.027979705,
-0.0071021286,
0.023329822,
-0.0277117,
0.025648065,
-0.004917889,
0.007973144,
0.004489081,
0.036716666,
-0.005869306,
0.011363406,
0.0087570585,
0.017916124,
-0.013427043,
0.016951306,
-0.010190885,
0.034117017,
0.0041373246,
0.028944524,
-0.012509126,
-0.010391888,
0.0046800347,
-0.01050579,
0.014793867,
-0.018599536,
-0.007242831,
-0.0067637726,
-0.009782177,
0.024830649,
0.018117128,
-0.013989853,
0.00165828,
-0.012120519,
0.018961344,
-0.017326513,
0.008964762,
-0.030043343,
-0.008093746,
-0.035108633,
0.006137311,
-0.00719593,
0.0005636477,
0.0013324866,
0.0037386676,
0.015611283,
-0.044193998,
-0.013869251,
-0.013065237,
0.0029564286,
0.034706626,
-0.0041339747,
-0.01049909,
0.026947888,
0.01161131,
-0.0025192455,
-0.009641474,
0.00018990655,
0.017473916,
-0.009051864,
-0.013313141,
0.005035141,
-0.019269548,
0.021922797,
-0.0031339817,
-0.0065460186,
0.011309804,
0.0025075204,
0.0042780275,
-0.010746994,
0.020167366,
-0.009326569,
-0.010103783,
-0.018612936,
-0.030043343,
0.07246851,
-0.008187548,
-0.007926243,
0.008810659,
0.007242831,
-0.029212529,
-0.14064895,
-0.007865942,
0.010901097,
0.010043481,
-0.019282948,
0.002932978,
-0.000109714485,
0.01322604,
-0.024683246,
0.0028492266,
-0.010988199,
-0.003378536,
-0.028328113,
-0.011437107,
0.00022131338,
0.008529254,
-0.0020837376,
-0.003762118,
-0.012368424,
0.028917722,
-0.005179194,
-0.027765302,
-0.0023366674,
-0.0022311404,
0.027001489,
0.004797287,
-0.0007139817,
0.03977192,
0.021802194,
0.011691712,
0.008743658,
-0.0016004915,
0.014525862,
-0.016750302,
-0.000059777645,
-0.0003800225,
-0.016844105,
0.008355051,
0.016897706,
-0.017540917,
0.0074170344,
0.0031674823,
0.017004907,
-0.004596283,
0.022298003,
-0.020689974,
-0.00883746,
0.0048240875,
0.0028927773,
-0.019041745,
-0.01492787,
-0.01767492,
-0.03974512,
0.002602997,
0.009648175,
-0.0028994775,
0.0084220525,
0.0277117,
-0.016549299,
0.00035761896,
-0.012428725,
-0.0011783838,
-0.014874269,
0.0064354665,
0.0388071,
-0.01987256,
-0.018023325,
-0.019510753,
0.025862468,
-0.017071908,
0.013453843,
-0.00047738364,
0.002102163,
-0.014123855,
-0.012006617,
0.0038458696,
-0.005078692,
-0.0066532204,
-0.026237674,
-0.00608371,
-0.011577809,
-0.0056482023,
-0.0062947636,
-0.026907686,
0.014847469,
0.01768832,
0.011886015,
-0.015611283,
0.0057219034,
0.008100446,
-0.04700805,
0.02603667,
-0.013695048,
-0.027135491,
0.00041477938,
0.023557626,
0.0023869183,
-0.017581118,
0.038405094,
0.013775449,
-0.0066096694,
-0.014083655,
-0.035778645,
0.025313057,
-0.010633092,
-0.012207621,
0.019215947,
0.022820612,
0.022834012,
-0.019108746,
-0.0022713412,
-0.0006603807,
-0.034492224,
0.011792214,
-0.024522444,
0.005082042,
-0.02048897,
-0.01598649,
0.014753667,
0.008107146,
0.008214349,
0.026117073,
0.012690029,
0.028837321,
0.005966458,
0.037413478,
-0.026425278,
-0.016361697,
-0.012294723,
-0.00071440043,
-0.015222675,
0.0151958745,
-0.0020535872,
-0.03248219,
-0.0019597854,
0.012261222,
-0.004311528,
0.00221439,
0.015745284,
0.020716775,
0.010117183,
0.025741866,
-0.022539208,
-0.022994816,
0.026720084,
-0.04301478,
-0.0071021286,
-0.0021808895,
-0.031731773,
0.0166163,
-0.0016448798,
-0.013400243,
0.021949597,
0.02097138,
-0.01602669,
-0.03829789,
-0.023463825,
0.007899443,
0.021359986,
-0.008515854,
0.0039530713,
-0.01764812,
0.0025711716,
0.00248407,
-0.008810659,
-0.00013944627,
-0.021708393,
-0.023932833,
-0.0132461395,
0.018318132,
-0.0016465548,
-0.028354913,
-0.0036783665,
-0.000089457084,
0.00058081676,
-0.0066264197,
-0.0061976123,
0.005296446,
0.013641447,
0.015048472,
-0.020395169,
0.020703375,
-0.001685918,
0.00828805,
-0.018599536,
0.014432061,
0.028113708,
0.008522554,
-0.01161801,
0.035751846,
-0.007879343,
-0.022003198,
-0.00048282748,
0.019979762,
0.0055007995,
-0.0070820283,
0.004241177,
0.028006507,
0.0049547395,
0.017018307,
0.012850832,
0.01385585,
0.027229292,
0.024160637,
0.0331254,
-0.028864123,
0.0065527186,
0.01877374,
-0.04365799,
-0.027497297,
-0.008783859,
0.015169075,
0.0020535872,
0.024522444,
-0.010478989,
-0.0012830732,
0.002100488,
0.030150546,
-0.014217657,
0.00058374804,
-0.031222565,
0.015919488,
0.027765302,
0.036234256,
-0.0096079735,
-0.013045136,
0.015879286,
0.003477363,
0.03650226,
-0.04025433,
0.021386787,
0.013963053,
0.011966417,
0.017514117,
-0.013829051,
-0.021426987,
-0.007477335,
-0.02373183,
0.023584427,
0.008006644,
-0.032428585,
0.06957406,
0.0141774565,
0.011778813,
0.01768832,
-0.025889268,
0.00067754975,
0.025152255,
0.011551009,
0.0018157328,
-0.012810632,
0.04636484,
-0.013869251,
0.018076926,
-0.025594464,
-0.0220836,
0.01818413,
-0.04143355,
0.0058324556,
-0.02651908,
-0.012341623,
0.019577755,
-0.016911106,
0.024308039,
0.0065359683,
-0.030579353,
0.013715148,
-0.0021859144,
-0.029132128,
-0.003212708,
-0.017567718,
0.018197529,
0.013118837,
-0.052823756,
-0.008542654,
-0.015798885,
0.00017713445,
-0.0110351,
-0.029989742,
0.0012864233,
0.004036823,
0.02267321,
0.020931179,
-0.037279475,
-0.019671556,
0.008696757,
0.011564409,
-0.03650226,
-0.013654847,
-0.0045493823
] |
Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component pathways, and the specificity of the phosphotransfer reactions within these systems is tightly controlled to prevent unwanted crosstalk. One of the best understood two-component signalling pathways is the chemotaxis pathway. Here, we present the 1.40 A crystal structure of the histidine-containing phosphotransfer domain of the chemotaxis HPK, CheA(3), in complex with its cognate RR | [
-0.010212038,
0.0031506647,
0.00927454,
-0.011296858,
-0.013145069,
0.029866025,
0.006184142,
-0.02241961,
-0.008290166,
-0.031982094,
0.0024307999,
-0.0034653964,
-0.01585712,
0.025700854,
0.0022165144,
-0.002979906,
0.027749958,
-0.0038705298,
-0.007473203,
0.010854894,
-0.022821393,
0.002000555,
0.01454462,
-0.029330311,
-0.0017109349,
0.019526755,
0.016874975,
-0.032544594,
-0.013339265,
-0.00579575,
-0.0033816912,
-0.0047109304,
-0.013212034,
0.002864393,
-0.003991065,
-0.012897301,
0.011249983,
0.0011886143,
0.021937467,
0.00037646428,
0.022124967,
0.012542391,
-0.013379443,
0.0036696373,
-0.01187275,
0.0031590352,
0.025660675,
-0.016084796,
-0.030080311,
0.031151738,
-0.013794621,
0.00828347,
-0.021803537,
-0.0020122738,
-0.00071902794,
-0.00068345317,
0.0142097995,
0.01501337,
0.010372752,
-0.010272305,
-0.00078850327,
0.008008916,
-0.031473167,
-0.0025881657,
-0.009488825,
-0.003632807,
0.01742408,
0.0049854834,
0.002189729,
0.0062310174,
0.03913387,
0.010613823,
-0.0027572503,
-0.0023772286,
0.024093714,
-0.018749971,
-0.030401738,
-0.0045502163,
-0.007091507,
0.011323643,
0.02549996,
-0.006180794,
0.012649534,
0.014343728,
0.020745505,
-0.021575859,
0.0063147224,
0.03187495,
-0.0103794485,
-0.009247754,
-0.0071919532,
0.03632137,
-0.0026802414,
0.0128638195,
-0.0054006614,
-0.003391736,
0.004583698,
0.03658923,
0.0004741901,
-0.038866013,
-0.013499979,
-0.006853784,
-0.00051646127,
-0.018374972,
-0.026919601,
0.02120086,
-0.0057522235,
-0.014986584,
0.011886142,
-0.018870506,
-0.028499957,
0.04513386,
-0.0054307953,
-0.040446367,
0.010359359,
0.012803552,
0.013238819,
0.005055796,
-0.003984369,
-0.026129425,
0.017745508,
0.033535663,
-0.0048950817,
-0.020933004,
0.04593743,
0.026892817,
-0.014464264,
0.0009776771,
-0.0047946353,
0.0060100355,
-0.011705339,
0.00076213613,
-0.0016121627,
0.010493288,
-0.019794613,
0.024415141,
-0.027508887,
-0.016205333,
-0.022124967,
-0.034151733,
0.023624964,
0.020437468,
-0.01680801,
0.005303563,
-0.005049099,
0.0011258353,
0.012053553,
0.030535668,
-0.0071115964,
-0.002881134,
0.022821393,
-0.011986589,
0.0016372743,
-0.000848771,
0.010888376,
0.02191068,
-0.0056417324,
0.021401754,
0.0011007237,
-0.02890174,
-0.0038705298,
0.011116054,
0.0130379265,
-0.0044263327,
0.033642806,
0.014772299,
0.015187477,
0.022366038,
0.0034001064,
-0.015267834,
-0.00029568872,
0.009622753,
-0.01897765,
-0.00062820775,
-0.007962042,
-0.004627225,
0.005481018,
0.013118284,
-0.016794616,
0.0004972091,
0.00051604275,
0.0026166255,
0.012522303,
0.018883899,
0.009488825,
-0.028124956,
0.01194641,
-0.0117589105,
0.012883909,
-0.019714255,
0.0018465373,
0.031071382,
0.0053203045,
-0.013111587,
-0.6231419,
-0.047249928,
0.0055915094,
-0.04098208,
0.027883885,
0.009368289,
0.01267632,
-0.0021847065,
-0.0125892665,
0.014062478,
-0.0155222975,
-0.007868292,
-0.003522316,
-0.03026781,
-0.04494636,
-0.03441959,
-0.0031807986,
-0.017959794,
0.033455305,
0.0068973107,
-0.01097543,
-0.019580327,
-0.018401757,
0.010995518,
0.00017274666,
0.0046540108,
0.029035669,
0.0082365945,
-0.010466502,
0.04457136,
-0.023812464,
-0.0062477584,
-0.004185261,
-0.0031657317,
0.045428503,
0.010499984,
-0.0049319123,
0.023156215,
0.03634816,
0.06326776,
-0.010426323,
-0.034821376,
0.024749963,
0.004868296,
-0.017745508,
0.0014966495,
0.005273429,
0.0069174003,
-0.008122755,
-0.010232127,
-0.0038136102,
-0.0016540153,
-0.02195086,
0.027080316,
0.020249968,
0.010707573,
0.023611572,
-0.005745527,
-0.028258884,
0.010714269,
-0.011417394,
0.009850431,
-0.0010496635,
-0.022004431,
-0.0017243277,
-0.0021010013,
-0.028714241,
-0.0047042337,
0.0012195852,
0.007078114,
0.024107106,
0.019808006,
0.0066528916,
-0.003937494,
-0.0053069117,
0.02643746,
0.008939719,
0.009060254,
0.0010521747,
0.016339261,
-0.00069098664,
0.014236585,
-0.03875887,
-0.000088413646,
0.035705302,
0.0055680717,
-0.009776771,
0.016660688,
0.0006872199,
-0.010359359,
0.0067332485,
-0.0233705,
-0.025660675,
-0.01746426,
-0.046151716,
0.030964239,
-0.0006424376,
0.00499218,
0.0019101533,
-0.033857092,
-0.02772317,
-0.025098177,
-0.013587032,
0.00018593024,
0.014504442,
0.0003287523,
-0.025098177,
0.0077410596,
0.038169585,
-0.0066930703,
0.006308026,
-0.010908466,
-0.009662932,
-0.009321414,
0.010292395,
-0.026732102,
0.035491016,
0.027200852,
0.014008907,
-0.021281218,
0.018629435,
0.0058392766,
0.011919624,
-0.028178528,
0.015080334,
0.03966958,
-0.002000555,
-0.012897301,
-0.019674078,
0.024709783,
0.0036997711,
-0.014839263,
0.02733478,
-0.022124967,
0.0031104863,
-0.0006198372,
0.01274998,
-0.0032862672,
0.0033431868,
-0.035276733,
-0.02718746,
-0.009562485,
0.014223193,
0.00063825236,
-0.0059765535,
-0.022540145,
-0.032598164,
0.008055791,
0.017035687,
-0.0057421788,
0.039107084,
0.001150947,
-0.007426328,
-0.009562485,
0.016084796,
-0.0038169585,
-0.010332573,
-0.0042153955,
-0.00067299005,
-0.020638362,
0.0016573635,
0.009823645,
-0.029892812,
-0.005648429,
-0.021066932,
-0.020906217,
0.02965174,
0.010613823,
0.015026763,
-0.024468713,
-0.0062243207,
-0.018763363,
-0.028312456,
0.025446389,
-0.00074958033,
0.022714252,
-0.0058091427,
-0.0043292344,
-0.0013367725,
-0.0074062385,
-0.0039307973,
-0.030241026,
-0.03144638,
-0.012428552,
0.017089259,
0.022834787,
0.02445532,
0.024535676,
0.017049082,
0.03857137,
-0.03058924,
0.012937481,
-0.0026467594,
0.024307998,
-0.011752214,
-0.025151746,
0.030964239,
0.004145083,
-0.01319864,
0.02568746,
0.021508895,
-0.018522292,
0.015482119,
-0.036241017,
0.00307533,
-0.018428544,
-0.02658478,
-0.02761603,
0.02120086,
0.022928536,
-0.009649538,
0.001809707,
-0.021455323,
-0.016861582,
0.00262667,
0.014249979,
-0.019017829,
0.024254426,
-0.03905351,
-0.0004997202,
-0.003860485,
-0.015026763,
0.010279002,
0.004148431,
0.008531237,
0.00798213,
0.002099327,
0.021107111,
-0.0016799639,
0.008698647,
-0.008993289,
0.014758906,
-0.011477661,
0.008504451,
0.007881684,
0.028339243,
0.0038136102,
0.0074196314,
0.049017783,
0.003937494,
0.0061908388,
0.010533466,
-0.013232122,
0.004647314,
-0.019620506,
0.012080339,
0.030535668,
0.020183004,
-0.024589248,
0.027040137,
0.0013409577,
0.018857114,
-0.01718301,
0.0029095937,
0.024950854,
0.0046874927,
0.015160691,
0.00962945,
0.046285644,
0.00476785,
-0.004305797,
0.009227664,
0.014343728,
-0.049178496,
-0.009656236,
0.019111577,
-0.010781233,
0.0015410132,
-0.029142812,
0.0062678475,
-0.0059799016,
-0.0064419545,
0.020517826,
0.0042723147,
0.014718727,
0.006964275,
-0.0031121604,
-0.011845964,
0.0031155087,
-0.0015577544,
-0.01069418,
-0.029116027,
0.037473157,
0.0073526674,
-0.004560261,
-0.0375803,
-0.017732115,
0.0069575785,
0.0013526765,
0.030187454,
0.004034592,
0.011263375,
-0.0015954217,
0.021575859,
-0.013794621,
0.00042752444,
0.024763355,
-0.023035679,
0.019540148,
0.0071316855,
-0.0049754386,
0.007024543,
-0.009616056,
-0.03516959,
0.030535668,
-0.0012898976,
-0.005092626,
-0.027883885,
-0.000044703822,
-0.016339261,
0.008470969,
0.014303549,
0.012575873,
-0.03262495,
-0.006803561,
0.006833695,
-0.016165154,
-0.0025898397,
0.03120531,
-0.0038002173,
-0.019767826,
-0.017665152,
0.00240234,
0.008363826,
0.03634816,
0.00054994336,
-0.0056551252,
0.025017818,
-0.022352645,
-0.017303545,
-0.025017818,
-0.028741028,
0.014852656,
-0.016366046,
-0.0036261105,
0.0031389461,
0.0007575323,
0.02965174,
0.010720965,
0.010848198,
0.010587038,
-0.030857095,
-0.011350429,
0.00764731,
0.012421856,
-0.009415164,
0.024200855,
0.024307998,
0.023812464,
0.0018549078,
0.0192589,
0.0053102598,
0.0117589105,
-0.03490173,
0.022808,
0.007064721,
0.0063281152,
-0.019151757,
-0.0035491018,
-0.030214239,
0.0046941894,
0.036803514,
-0.010660698,
0.020973181,
0.016848188,
0.008216505,
0.02030354,
0.009843735,
-0.015830332,
-0.008665165,
0.01714283,
0.013633908,
-0.030321382,
-0.016499974,
0.009421861,
0.005484367,
0.002400666,
-0.015683012,
-0.0033733207,
-0.017062474,
0.014062478,
-0.023156215,
-0.007921862,
-0.016633904,
-0.012662927,
-0.021080324,
0.02568746,
-0.009287932,
0.0040948596,
0.01770533,
-0.007332578,
-0.04079458,
-0.022767821,
0.0009174093,
-0.0077075777,
-0.0282321,
-0.006883918,
-0.0022700857,
0.021616038,
0.024964247,
-0.0011157907,
-0.012274534,
-0.030749952,
0.013526765,
-0.02152229,
-0.008129451,
-0.005203117,
-0.036562443,
-0.005872759,
0.008370522,
0.01097543,
-0.001441404,
-0.022031216,
0.001103235,
0.009421861,
-0.0056216433,
0.01572319,
-0.013379443,
-0.020290148,
0.022647286,
0.013238819,
0.024522284,
-0.00017546708,
0.009401771,
-0.026504423,
-0.02256693,
-0.016473189,
-0.021107111,
0.012783462,
-0.0090669505,
0.0051127155,
0.008658469,
-0.011022304,
-0.008638379,
0.0045368234,
-0.009328111,
-0.008912933,
0.008872754,
0.015374976,
0.018964257,
0.020290148,
-0.0006424376,
-0.010640609,
-0.000020690886,
-0.0075803455,
0.01052677,
0.024723176,
-0.005511152,
-0.02624996,
0.01187275,
-0.001633089,
-0.0091339145,
-0.04028565,
-0.016874975,
-0.018991042,
0.029544597,
0.010392841,
-0.022299074,
-0.021616038,
0.003746646,
-0.026450852,
0.006003339,
0.009435253,
-0.02195086,
-0.010305787,
0.00011436227,
0.020638362,
-0.005092626,
-0.01015177,
-0.028874956,
-0.033214234,
-0.0011936366,
-0.019111577,
0.013325873,
0.019084793,
0.00021679654,
-0.02233925,
-0.0073727565,
-0.020062469,
-0.06905346,
-0.0071383817,
-0.0031021158,
0.020531218,
0.011055786,
0.01585712,
-0.018964257,
-0.006137267,
0.03182138,
0.014357121,
-0.014330335,
-0.012187481,
0.006870525,
-0.047437426,
0.014959798,
0.0077745416,
-0.010841501,
0.007680792,
0.018026758,
0.033589233,
0.015428548,
0.008504451,
-0.02247318,
-0.0029095937,
-0.031044595,
-0.0136473,
0.0025329203,
-0.038785655,
-0.008517844,
-0.03634816,
-0.0024107106,
0.01534819,
-0.0036461998,
-0.0031422942,
-0.006080348,
0.027803529,
-0.0152142625,
0.018294616,
-0.027227636,
0.03763387,
-0.0046941894,
-0.0075133815,
-0.011564715,
-0.0009969292,
0.021897288,
0.019339256,
0.0013869957,
-0.012689712,
0.0047176266,
-0.009462039,
-0.01449105,
-0.02847317,
-0.015883904,
-0.027803529,
-0.00918079,
-0.0113437325,
-0.0062644994,
-0.005953116,
-0.054642774,
-0.009595968,
-0.019138364,
-0.008497755,
0.015991047,
-0.023825856,
-0.010674091,
0.046044573,
-0.0065122666,
0.026182996,
-0.014330335,
0.027200852,
0.04499993,
0.010660698,
-0.01936604,
-0.021267824,
-0.029249955,
0.00783481,
0.0480535,
0.030857095,
-0.02578121,
-0.020236576,
0.0008353782,
0.0032712002,
-0.011417394,
-0.03991065,
0.01983479,
0.006421865,
0.009977663,
-0.0024291258,
0.008383916,
-0.021174075,
0.01949997,
-0.005511152,
-0.0076607023,
0.003122205,
0.0016833121,
-0.017075866,
-0.0050022244,
-0.0018934123,
0.027830314,
0.0071986495,
-0.027348172,
-0.0036830301,
-0.008156237,
0.007031239,
0.017933007,
0.004339279,
0.017772295,
0.004212047,
0.025861567,
0.03026781,
0.0008822531,
0.0016171851,
-0.0124486415,
0.017839259,
0.043098148,
0.0030853748,
-0.01482587,
0.016111583,
0.03219638,
0.0064386064,
-0.008511147,
-0.00073995424,
-0.020209791,
-0.04023208,
0.014062478,
0.021348182,
0.02866067,
-0.013332569,
-0.020665146,
-0.014075872,
0.008511147,
-0.025700854,
-0.0017963143,
0.032035664,
-0.04593743,
-0.023156215,
-0.007680792,
-0.005511152,
0.032651737,
0.018723186,
0.014638371,
-0.0042622704,
0.035035662,
-0.040714223,
0.0130379265,
0.017624972,
0.022553537,
-0.022272287,
0.0064687403,
-0.006532356,
-0.022232108,
0.030053526,
-0.030669596,
-0.0119999815,
0.007466506,
-0.008055791,
0.024227642,
0.027937457,
0.0000047280373,
-0.00069349783,
0.008055791,
0.016941939,
-0.0028710894,
0.024669604,
0.02370532,
-0.005732134,
0.023437465,
0.016058011,
-0.016473189,
-0.0054307953,
-0.006977668,
-0.018991042,
-0.0061071333,
0.007265614,
-0.028151743,
-0.00880579,
-0.0030502186,
-0.01321873,
-0.003860485,
0.010312485,
-0.01804015,
-0.023785679,
0.011203107,
0.012462035,
-0.013888371,
-0.00198214,
-0.009073647,
-0.0016598747,
-0.0039140563,
-0.015334798,
0.0047511086,
0.019473184,
-0.02686603,
-0.022861572,
0.0034168474,
-0.0065122666,
0.051803492,
0.003934146,
-0.014999977,
-0.011116054,
-0.00970311,
-0.036107086,
-0.030080311,
-0.014705335,
-0.019473184,
-0.008229898,
0.0064118207,
-0.0014028996,
-0.007694185,
-0.021107111,
0.016017832,
0.015843725,
-0.006368294,
-0.000031232514,
-0.009863825,
0.0091607,
0.0077410596,
-0.039508868,
-0.0058392766,
0.036267802,
-0.038785655,
0.0048783408,
0.03782137,
-0.020477647,
-0.0008630009,
0.0034151734,
-0.0047912872,
0.017999973,
0.036267802,
0.011209805,
-0.013325873,
-0.015549083,
0.0032193032,
0.0030485445,
-0.0042020027,
0.0071517746,
0.011564715,
0.020598182,
0.011825874,
-0.00918079,
-0.021254431,
0.01779908,
-0.008162934,
0.010419627,
0.015415155,
0.009462039,
-0.005481018,
0.016767832,
-0.0016941938,
0.0018381668,
-0.021883896,
-0.021401754,
-0.0049754386,
-0.021642825,
0.0027589244,
0.007714274,
0.0025563578,
-0.0034553518,
-0.015991047,
-0.00069098664,
0.011665161,
-0.0037232086,
-0.023330322,
0.034741018,
0.01544194,
-0.014758906,
-0.023504429,
0.0013895067,
-0.030374954,
-0.002882808,
-0.014236585,
0.020249968,
0.00065122667,
0.0027790135,
-0.0003218466,
-0.019540148,
0.021214252,
-0.012790159,
-0.00272042,
-0.034178518,
0.008457576,
0.17989258,
-0.011537929,
0.010493288,
-0.0006696418,
0.0019168498,
-0.005330349,
0.008946415,
0.006659588,
0.0054307953,
-0.0032259994,
0.013941943,
0.029999955,
-0.020330327,
-0.0026300184,
0.0056919553,
-0.012837034,
-0.020504434,
-0.018830327,
-0.026892817,
0.014651763,
0.009763378,
0.00006795818,
0.0042220918,
-0.016540153,
0.041330293,
-0.014062478,
-0.025888354,
0.007540167,
0.021964252,
-0.006197535,
-0.02884817,
-0.0010647305,
0.012515605,
0.0042321365,
0.024749963,
0.008397308,
-0.014437478,
-0.0050959745,
0.02312943,
0.0066930703,
-0.003763387,
0.01680801,
0.013004445,
0.008946415,
-0.0084776655,
-0.01491962,
-0.0036629408,
-0.011524536,
0.0027823618,
-0.004111601,
-0.047223143,
0.009575878,
0.00036139734,
0.030080311,
-0.008122755,
-0.006766731,
0.008611594,
0.00094670616,
-0.014102657,
0.016084796,
-0.031767808,
0.0011116054,
-0.030133883,
0.020571398,
-0.012053553,
0.0373928,
-0.035330303,
0.0062778923,
0.010948644,
-0.017558008,
-0.0175714,
0.0013493283,
-0.009435253,
-0.006626106,
-0.016111583,
-0.009924092,
0.006133919,
0.017450865,
0.04826778,
0.02129461,
-0.014263371,
0.00095507666,
-0.03399102,
-0.0049854834,
0.0059765535,
-0.014745513,
0.043553505,
0.010908466,
-0.030535668,
0.024307998,
0.02549996,
-0.0029162902,
-0.029357098,
-0.012917391,
0.01284373,
-0.005059144,
-0.0139017645,
0.0069374894,
-0.011089269,
-0.00036746595,
-0.03318745,
0.06508919,
-0.016540153,
0.0066897217,
-0.014705335,
0.012917391,
-0.00092075753,
0.008183023,
0.0064888294,
-0.01949997,
0.0007491618,
-0.005936375,
0.014986584,
-0.000012019547,
0.001967073,
0.014035692,
0.0053437417,
0.014839263,
0.019928541,
-0.013158462,
0.008424094,
-0.017370509,
-0.014357121,
0.022741036,
-0.025446389,
0.013426319,
-0.01940622,
0.002286827,
0.0007972923,
-0.04084815,
0.0148660485,
0.010546858,
0.0035624946,
0.017919615,
-0.010299091,
-0.029330311,
0.020879433,
-0.016593724,
-0.035276733,
0.02166961,
0.018482115,
0.007540167,
0.005698652,
0.029517813,
0.007901774,
-0.023075858,
0.0093749855,
0.010037931,
-0.03498209,
-0.009381682,
0.011229893,
0.0010379448,
-0.011183019,
-0.0060535623,
0.011089269,
-0.023343714,
-0.020558003,
-0.02152229,
0.029062456,
0.0063950797,
-0.014691941,
0.00217801,
0.009823645,
0.0077410596,
-0.009743288,
0.010674091,
-0.16799974,
0.02252675,
0.019580327,
-0.01566962,
0.04529457,
0.0360803,
0.011156233,
0.011270072,
0.016044619,
0.0011894513,
0.03881244,
0.0034787892,
-0.008678558,
-0.059410624,
0.027227636,
-0.010513376,
-0.014986584,
0.040901724,
0.0056149466,
0.00105636,
0.020999968,
-0.007921862,
0.027535671,
0.0135535505,
-0.003281245,
0.021040147,
-0.0049017784,
-0.007232132,
-0.0060435175,
-0.024816927,
-0.016419617,
0.0047109304,
0.015924083,
0.0030652855,
0.013627212,
-0.0124486415,
0.01699551,
-0.00014564709,
0.0016992162,
0.024589248,
0.036267802,
0.012515605,
0.02105354,
0.010051324,
-0.022593716,
0.03101781,
-0.017785687,
0.02237943,
0.011892839,
-0.016941939,
0.010613823,
0.0056718662,
0.012522303,
0.01761158,
0.027830314,
0.0031489907,
-0.02421425,
0.019151757,
-0.0131048905,
0.009448647,
0.009462039,
-0.00035951397,
0.013084801,
-0.011926321,
-0.008243291,
-0.017062474,
-0.012903998,
0.0045401715,
-0.033562448,
0.003632807,
-0.0022031215,
-0.036535658,
0.0032410664,
-0.018575864,
0.019982113,
0.007185257,
-0.010982126,
-0.007245525,
-0.014062478,
0.0054341434,
0.0062042316,
0.01449105,
-0.023142822,
-0.021964252,
-0.0047276714,
-0.015334798,
-0.026598174,
0.011183019,
0.0091004325,
-0.011196411,
0.02464282,
-0.023450857,
0.005484367,
-0.0139687285,
0.009495521,
0.0053102598,
-0.008792398,
-0.0009575878,
-0.002194751,
0.0069240965,
0.03669637,
-0.0027103752,
-0.001808033,
0.0017979883,
0.002673545,
0.012241052,
-0.0068973107,
-0.00089815713,
0.046366,
0.012053553,
0.0029497722,
-0.0062176245,
0.0091004325,
0.027910672,
-0.025098177,
0.03002674,
0.011464268,
0.005276778,
0.0062477584,
-0.040258866,
0.04631243,
0.0142097995,
-0.020142825,
0.00908704,
-0.0066629364,
-0.029624954,
-0.13810693,
-0.0015795176,
0.011665161,
-0.00439285,
-0.015950868,
0.009803557,
0.0008115222,
0.011129447,
-0.004821421,
0.028633885,
-0.016325869,
-0.013540158,
-0.016151762,
-0.0077276668,
0.0075602564,
0.011819178,
0.026906209,
-0.02866067,
-0.00764731,
0.041624937,
-0.013546854,
-0.011008912,
0.009093736,
0.0054475362,
0.0024224294,
-0.0065524452,
-0.02241961,
0.010968734,
-0.0022181885,
0.006549097,
0.011785696,
-0.012113821,
0.012328106,
-0.011450876,
-0.0034151734,
-0.011825874,
-0.012046857,
-0.019178541,
0.025593711,
-0.0010387818,
0.0003902756,
0.0012940828,
0.03120531,
-0.01088168,
0.022714252,
-0.0011601545,
0.0051294565,
0.011075876,
0.0100312345,
-0.0082700765,
-0.031285666,
-0.042133864,
-0.033883877,
-0.009267843,
0.034124948,
-0.029973168,
-0.0073124887,
0.034741018,
-0.007874988,
0.005986598,
-0.011316947,
0.007285703,
-0.015200869,
0.022593716,
0.006806909,
-0.008645076,
-0.014236585,
-0.015415155,
0.02266068,
-0.02054461,
-0.017785687,
0.02015622,
-0.0026701968,
0.00396428,
-0.012930783,
0.016366046,
-0.04055351,
-0.019607114,
0.001150947,
-0.016741045,
-0.0012438596,
-0.026169602,
0.008390612,
-0.02847317,
0.009749985,
0.0009065276,
0.0015912364,
0.0036629408,
0.011377214,
-0.028312456,
-0.015683012,
0.02062497,
-0.0018850417,
0.009368289,
0.025848174,
0.0119330175,
-0.0034988786,
0.0013585358,
0.016553545,
0.020049077,
-0.03318745,
0.0025730988,
-0.06616061,
-0.0011568062,
0.018455328,
-0.021776753,
0.0237455,
-0.00025592872,
0.00089899416,
0.00079352554,
0.011002216,
0.018830327,
-0.019459791,
0.01964729,
-0.009462039,
-0.018683007,
-0.016352654,
-0.014705335,
0.020223184,
-0.019928541,
0.01609819,
0.008055791,
-0.01699551,
-0.02228568,
0.03881244,
0.022754429,
0.007245525,
0.009944181,
-0.01940622,
0.021348182,
-0.0013920179,
0.022165144,
0.026383888,
-0.035892803,
-0.0061071333,
-0.011417394,
-0.0048917336,
-0.032919593,
-0.019031221,
0.029035669,
0.0133124795,
0.029383883,
-0.020089256,
-0.031499952,
-0.010071413,
-0.022392822,
0.011571411,
-0.0013191944,
-0.043607075,
0.004821421,
-0.0020440817,
0.0003739531,
0.026892817,
0.012857123,
0.00018938308,
-0.030857095,
-0.010794627,
0.0029882768,
-0.0049252156,
-0.02162943,
0.013587032,
-0.037366014,
0.0024291258,
0.014973192,
0.022928536,
-0.011531232,
-0.008966504,
-0.01959372,
-0.035437446,
-0.009910699,
0.006783472,
-0.053946346,
-0.027080316,
0.012308016,
0.012187481,
0.0135535505,
0.00060267764,
0.014758906,
-0.0070044533,
-0.0055479826,
-0.015120513,
-0.0002833422,
-0.00012880142,
-0.019888362,
-0.0077276668,
0.008973201,
0.020959789,
0.009924092,
-0.0054307953,
0.011979892,
0.0022968715,
0.013627212,
0.010218734,
0.0084441835,
0.014665156,
-0.00064745994,
0.029116027,
0.0289821,
0.0037533424,
-0.009093736,
-0.0054508843,
0.02653121,
-0.01133034,
0.0028727634,
0.0008596527,
-0.034874946,
0.0049888315,
0.015830332,
-0.023075858,
-0.015883904,
-0.02342407,
-0.004396199,
0.0048917336,
0.0070714178,
0.004854903,
0.003957583,
-0.016165154,
-0.0022466483,
-0.024522284,
-0.0007328393,
-0.012870516,
0.037714228,
0.010640609,
0.0148660485,
-0.00798213,
-0.005069189,
0.025419604,
0.011444178,
0.019995505,
-0.0038939673,
0.016339261,
0.009214272,
-0.0040446366,
0.023839248,
-0.0097566815,
-0.010888376,
0.0058526695,
-0.009013379,
-0.0010764493,
0.017169617,
-0.019138364,
0.09026772,
0.010004449,
-0.014196407,
0.024629427,
-0.017624972,
0.013613818,
0.0040714224,
0.00019325444,
-0.026196389,
-0.03961601,
0.007734363,
-0.0013359354,
0.020531218,
-0.010131681,
0.01267632,
0.0037600389,
-0.020812469,
-0.0050859298,
0.013084801,
-0.02578121,
0.0025664023,
-0.000880579,
-0.0043191896,
0.034553517,
-0.01996872,
-0.018749971,
0.020758897,
-0.0011157907,
0.008758916,
-0.026370496,
0.017437473,
-0.0017561357,
-0.054696344,
-0.013560247,
-0.009977663,
0.0015343168,
-0.016031226,
0.007955345,
0.030535668,
0.024495497,
0.021160683,
-0.019781219,
-0.019165149,
-0.030107096,
-0.0050993226,
0.009294628,
-0.004017851,
0.00045493792,
0.012107125
] |
IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline and bupropion sustained-release (SR; combination therapy) compared with varenicline (monotherapy) in cigarette smokers. DESIGN, SETTING, AND PARTICIPANTS Randomized, blinded, placebo-controlled multicenter clinical trial with a 12-week treatment period and follow-up through week 52 conducted between October 2009 and April 2013 at 3 midwestern clinical research sites. Five hundred six adult (≥18 years) cigarette smokers were randomly assigned and | [
-0.021576745,
-0.0073505407,
0.024706913,
-0.016386556,
-0.03700017,
0.018138913,
0.010942206,
-0.0029980708,
-0.03526119,
-0.008661465,
-0.014286401,
0.019249186,
-0.008119705,
0.023743784,
0.009270108,
0.0015517065,
0.028947352,
-0.026325503,
-0.010514149,
-0.019770881,
-0.01213274,
0.015129138,
-0.012072544,
-0.02588407,
-0.00415349,
0.012065856,
0.004504631,
-0.029348655,
-0.011778255,
0.0049293432,
0.0005965208,
0.028010977,
-0.005019637,
-0.033789746,
-0.0208544,
-0.010259991,
-0.019222433,
0.00250313,
0.007444178,
-0.009002573,
0.011932088,
-0.0022372664,
-0.0033843254,
0.0323183,
-0.014888356,
-0.007531127,
-0.0030482337,
-0.025001202,
-0.020172184,
0.009811868,
0.004340765,
0.0028893845,
-0.03202401,
0.0048758364,
0.018714115,
-0.015717717,
-0.01649357,
0.03764226,
0.011704682,
-0.02314183,
-0.018473333,
-0.004805608,
-0.002486409,
0.013483794,
-0.022740526,
0.006430887,
-0.021429602,
0.0061432864,
-0.0021118592,
0.019797634,
0.037802782,
0.035047162,
0.011524096,
0.014594067,
0.02675356,
0.0046885614,
-0.014099126,
-0.0015057238,
-0.0017439977,
0.006056337,
0.015971875,
-0.011898646,
-0.0024111646,
0.014273024,
0.03140868,
0.015222776,
0.016587207,
-0.0045547937,
-0.011443836,
-0.016319672,
-0.014099126,
0.032425314,
-0.008380553,
0.025857316,
-0.0063405936,
0.01491511,
0.0114505235,
0.028599557,
-0.0074843084,
-0.014687705,
-0.0022222176,
-0.0027890587,
-0.0025198509,
-0.007136512,
-0.01927594,
0.0033040647,
-0.033843253,
-0.023797292,
0.025362374,
-0.006484394,
-0.0074843084,
0.048049394,
-0.03547522,
-0.023008062,
0.0014304795,
0.009952324,
-0.0026703398,
-0.004421026,
0.003036529,
-0.032131024,
-0.0011529112,
-0.01345704,
0.025991084,
-0.009423941,
0.036063798,
0.0018660608,
-0.018379696,
-0.015998628,
0.0063405936,
-0.0149819935,
-0.00019448584,
0.023944436,
0.005969388,
0.0028007634,
-0.013644315,
0.0021235638,
-0.0040264106,
-0.019168926,
-0.04120048,
-0.018299434,
-0.00028404756,
0.020881154,
-0.015262906,
-0.017924884,
-0.02991048,
0.016092267,
0.045668326,
0.02787721,
-0.004357486,
-0.013530613,
0.020346083,
-0.041815814,
-0.013095868,
0.00411336,
0.01129669,
-0.002775682,
-0.014460299,
0.024961071,
0.0021737267,
0.0014488725,
0.0051065856,
-0.023984566,
0.008761791,
0.02031933,
0.030820101,
0.025027955,
0.0121996235,
-0.019770881,
-0.0077919746,
0.007965872,
-0.016881496,
0.04291271,
-0.028117992,
0.027101357,
-0.015410051,
-0.004718659,
-0.0013962014,
-0.00631384,
0.00051207986,
-0.015463558,
-0.0066582924,
0.011089351,
0.031221405,
0.021335965,
-0.009383812,
-0.003258918,
0.0038190708,
-0.0010216516,
-0.0032472133,
-0.015985252,
-0.012594238,
0.022031557,
-0.0010776669,
-0.0216035,
-0.6245351,
-0.027302008,
-0.007698337,
-0.01927594,
0.028599557,
0.015236152,
0.052329965,
0.025616534,
-0.0014890028,
0.028974105,
0.018673984,
0.028947352,
0.025563026,
-0.0070428746,
-0.0028509262,
-0.004996227,
0.0022790688,
-0.003464586,
0.012647745,
-0.012065856,
-0.026432518,
0.036411595,
-0.01495524,
0.032746356,
0.024947695,
0.007276968,
0.018205797,
-0.01886126,
0.001406234,
0.010641228,
-0.007464243,
0.035876524,
0.03298714,
0.0015416739,
0.045213517,
-0.013684446,
-0.010199795,
-0.0029763335,
0.03178323,
0.028760077,
-0.0123868985,
0.0009581119,
0.009604528,
-0.0024813926,
-0.040852685,
-0.003101741,
0.019396331,
0.007276968,
0.009584463,
-0.007925742,
0.03127491,
0.0028158121,
-0.018406449,
-0.009992454,
0.023757162,
0.00473538,
0.009049391,
-0.0042571602,
-0.006758618,
-0.0118250735,
-0.0055714287,
-0.002521523,
-0.0026552908,
-0.015624079,
-0.01375133,
0.026312126,
-0.010407135,
0.018954897,
0.024573145,
-0.0116377985,
0.018633854,
0.009898817,
0.0057352944,
-0.01063454,
0.015891615,
0.017055394,
-0.0028158121,
0.012306638,
-0.019971533,
0.012467159,
0.011530784,
-0.013791461,
-0.031301666,
0.0009974062,
0.01848671,
-0.026967589,
-0.011617733,
0.003929429,
0.0002416181,
0.0017924885,
0.012032414,
-0.008915624,
-0.0064743613,
-0.013684446,
-0.030258276,
0.035716,
0.0054644146,
-0.0056450013,
0.0016252787,
-0.025522897,
-0.022901047,
0.003192034,
0.008500944,
0.005952667,
0.015249529,
-0.016038759,
-0.014072373,
-0.013463729,
0.029937234,
-0.01532979,
0.027328761,
-0.014647574,
-0.0011704683,
0.002126908,
-0.0027071259,
-0.032505576,
0.024439378,
-0.02501458,
-0.012728007,
-0.04593586,
0.0059894533,
0.0036919913,
0.012467159,
-0.011443836,
-0.014313155,
0.011570915,
0.01757709,
0.007096382,
-0.0066917343,
-0.022887671,
0.029937234,
0.0052436977,
0.010855257,
0.0041601784,
0.0121996235,
-0.0025516208,
0.015971875,
-0.0052403538,
-0.019396331,
-0.020546734,
-0.024693536,
0.022379354,
0.01412588,
0.010714801,
-0.00079508236,
-0.03301389,
0.017229293,
-0.008648088,
-0.035368208,
-0.020506604,
0.036812898,
-0.017670726,
-0.008674841,
0.0043942723,
0.015436804,
-0.014527183,
-0.0153565435,
-0.033923514,
-0.021737268,
0.007323787,
0.017443322,
0.0050296695,
-0.0041902764,
-0.021871036,
-0.008761791,
-0.02484068,
-0.0018760934,
0.025456013,
0.02825176,
-0.030686334,
0.0118250735,
-0.04462494,
0.0074040475,
0.021549992,
-0.0046952497,
-0.005895816,
-0.011985595,
0.0034160952,
0.017389813,
-0.0029261706,
-0.012748071,
0.022205455,
-0.005778769,
0.010025897,
0.0094506955,
-0.008393929,
0.018138913,
-0.00049953914,
0.008748414,
-0.0011395344,
-0.00880861,
0.03057932,
-0.0015517065,
0.0466047,
-0.008915624,
0.006996056,
0.016105643,
0.010614475,
0.005902504,
0.022660265,
0.018714115,
-0.0056450013,
0.022740526,
-0.02093466,
0.011724748,
-0.00905608,
-0.0046049566,
0.003464586,
0.016694222,
-0.008541074,
0.0057854573,
0.0053406795,
-0.028010977,
-0.008380553,
-0.015945122,
0.027061226,
0.005300549,
0.004618333,
-0.01200566,
0.011871892,
-0.00768496,
-0.024359116,
0.006263677,
-0.0017557024,
-0.017282799,
0.026084721,
0.006705111,
0.00822672,
0.024439378,
-0.0077050254,
0.0038558568,
0.015557195,
0.0038123822,
-0.023864176,
0.023703653,
-0.0151692685,
0.009517579,
-0.04368856,
0.02231247,
0.019182302,
0.0022372664,
0.045989368,
0.017122278,
0.010520837,
0.026700053,
0.0076381415,
0.009778426,
0.023703653,
0.006842223,
0.010534214,
-0.017496828,
0.033040646,
-0.012901904,
-0.011564226,
0.008801921,
-0.002434574,
-0.002143629,
0.0050965534,
0.033254676,
0.045347285,
0.004471189,
0.024479507,
-0.0049427203,
-0.0025934232,
0.013008919,
0.01823255,
-0.0251751,
-0.005504545,
0.0021152033,
-0.0046885614,
0.004952753,
-0.0049126223,
-0.0042805695,
-0.0130758025,
0.019115418,
0.010206483,
-0.010627852,
0.02468016,
0.011196365,
0.016935004,
-0.014326531,
-0.012647745,
0.033308182,
0.015878238,
-0.00095978397,
0.0035114049,
-0.009992454,
-0.0018961586,
-0.014781342,
0.017630596,
-0.0023894273,
0.010868634,
-0.013109244,
0.01923581,
0.0008088772,
-0.0067820274,
0.036491856,
-0.013316585,
-0.0057252618,
-0.01769748,
0.018754246,
0.01844658,
-0.009457383,
-0.012453782,
0.008166525,
-0.030124508,
-0.019008404,
-0.030311784,
0.0024329019,
0.004802264,
0.010708112,
-0.0023158551,
-0.0077250903,
-0.012019037,
0.019904649,
0.022740526,
-0.028546048,
0.0104205115,
0.026084721,
-0.021402849,
0.00021590959,
-0.011229807,
0.0066984226,
-0.009798491,
0.058643803,
0.00018131807,
0.003942806,
0.015878238,
-0.00797925,
0.012146116,
-0.0014313154,
-0.009898817,
0.0091697825,
0.0050564227,
0.0041936208,
-0.015436804,
0.0078923,
0.0072970334,
0.02056011,
0.011142857,
0.0022523154,
-0.03344195,
0.0072100842,
-0.03892643,
0.00010241597,
0.019262563,
0.022740526,
0.017496828,
0.0070562516,
0.019008404,
0.027114732,
0.025857316,
0.029642945,
-0.015878238,
-0.0034411766,
-0.0035548792,
-0.009785115,
0.034886643,
-0.0030933805,
-0.0193562,
0.017095525,
-0.008641399,
-0.012774825,
0.022232208,
0.027903963,
0.007618076,
0.009464072,
-0.008929,
0.0011788288,
-0.037802782,
0.021817528,
0.004748757,
0.0046885614,
-0.019703997,
0.008119705,
0.010527526,
0.007511062,
-0.018245928,
0.012500601,
0.00026858065,
-0.00679206,
-0.022151947,
-0.033094153,
-0.025054708,
-0.015624079,
-0.030873608,
0.010681359,
-0.014032242,
-0.03253233,
-0.020680502,
-0.020867776,
-0.024412623,
-0.003859201,
-0.011055909,
-0.00027485102,
-0.0035916655,
-0.0055948384,
0.022914425,
0.01454056,
-0.004497942,
0.020720633,
-0.008467502,
-0.0114505235,
0.027716689,
-0.006761962,
-0.009965701,
-0.0044277143,
-0.0063907565,
-0.015650833,
-0.006721832,
-0.003359244,
-0.021884412,
-0.0050831763,
0.021282457,
0.0042805695,
-0.013370092,
0.033629224,
-0.04462494,
-0.011015778,
-0.0043842397,
0.006755274,
0.011162923,
0.014152633,
-0.0102332365,
0.020800892,
0.0020148775,
0.012975477,
-0.03651861,
0.0004581547,
-0.0052938606,
-0.008708284,
-0.00079675444,
-0.02558978,
-0.009604528,
0.013844967,
-0.009691477,
-0.04253816,
0.025402505,
0.024225349,
0.01495524,
-0.02209844,
0.02513497,
0.002110187,
-0.015838107,
-0.003564912,
0.006989368,
0.027342139,
0.0021051709,
-0.033308182,
-0.0025633255,
0.0058188993,
-0.009236666,
-0.020145431,
0.016587207,
0.0032689506,
0.03825759,
0.0031669526,
-0.043019723,
-0.030499058,
-0.008360487,
-0.025429258,
0.006501115,
-0.01383159,
-0.02326222,
0.00042157757,
0.009825245,
-0.017510206,
-0.004454468,
0.008621335,
-0.01528966,
0.01076162,
0.025228607,
-0.019035159,
0.0009572758,
0.0008042789,
-0.009684789,
-0.026352257,
-0.005608215,
-0.012808267,
-0.035207685,
-0.012901904,
-0.012968788,
0.007878924,
0.020667125,
0.025496142,
0.00943063,
-0.009912194,
-0.010641228,
0.011577603,
-0.009872064,
-0.0013736282,
0.008280227,
-0.026352257,
0.036251076,
-0.007785286,
0.003016464,
0.012774825,
-0.012748071,
0.017924884,
0.013343338,
-0.012694565,
-0.0016771138,
-0.03301389,
0.0029980708,
-0.0008168196,
-0.01005265,
-0.0024312297,
-0.0013075803,
-0.03336169,
-0.0119521525,
0.002366018,
0.02043972,
0.0003055758,
0.0037187447,
0.015035501,
-0.033174414,
0.018031899,
0.0096714115,
-0.0017406535,
-0.007169954,
-0.00080720504,
-0.021135312,
-0.012540732,
0.008654777,
0.016306294,
0.008694907,
0.013089179,
-0.0034010464,
-0.025041332,
0.012982165,
-0.01848671,
0.0036652377,
-0.008735037,
0.00008031293,
-0.003942806,
-0.0025767023,
0.00483905,
-0.013156063,
-0.0023777226,
0.012520666,
0.0015684274,
0.038204085,
-0.015155892,
-0.0045748586,
-0.013102556,
-0.047835365,
0.0201053,
0.010855257,
0.015410051,
0.039943065,
-0.008942378,
-0.020332705,
-0.009270108,
-0.012039102,
0.0008017708,
0.008801921,
0.03675939,
-0.01690825,
0.020453097,
-0.0069693024,
-0.0018777655,
-0.03472612,
-0.04237764,
0.011303379,
0.0061432864,
-0.0047788545,
-0.011129481,
-0.015637456,
-0.02750266,
0.026151605,
-0.008046133,
0.0085143205,
0.021282457,
-0.021215573,
-0.013390156,
0.02114869,
-0.0001149567,
0.0023727063,
0.020078547,
-0.0030315127,
-0.019008404,
0.016506946,
0.0037321215,
-0.0144201685,
-0.009992454,
0.040611904,
0.00589916,
-0.02069388,
-0.012687876,
0.002934531,
-0.011845139,
-0.005698508,
-0.017135656,
0.0372142,
-0.016172526,
-0.00073864905,
0.008648088,
-0.034806382,
0.016640713,
0.0034344883,
-0.008949066,
-0.010447266,
-0.027154863,
-0.010413824,
0.011316756,
0.036812898,
-0.0104205115,
-0.0055814614,
0.012861774,
-0.02738227,
-0.01832619,
0.004832362,
0.012019037,
-0.058643803,
0.021697138,
-0.016935004,
-0.009564398,
0.04807615,
0.0032555738,
0.009551021,
0.0008694907,
0.014674327,
-0.037802782,
0.007096382,
0.01383159,
0.03344195,
-0.009517579,
0.019918025,
-0.02060024,
-0.05382816,
-0.0028208285,
-0.0027539446,
-0.052115936,
-0.022700395,
-0.016025383,
-0.009457383,
0.010460642,
-0.015731093,
0.03863214,
-0.019302694,
0.008708284,
-0.020734008,
-0.029963987,
0.023288975,
0.003036529,
0.016506946,
0.030392043,
-0.03935449,
-0.004805608,
-0.012105986,
0.017028641,
-0.00026314636,
-0.033682734,
0.02961619,
-0.030017495,
0.017991768,
-0.027275255,
0.0054109073,
0.018888013,
-0.0022656922,
-0.008554451,
0.03788304,
-0.01262768,
-0.038337853,
-0.008099641,
0.00018936505,
-0.011871892,
-0.00065253605,
-0.010875322,
-0.0014605771,
-0.017269423,
0.006384068,
-0.038311098,
-0.021991426,
-0.006019551,
0.023422742,
0.0057419827,
-0.0024563111,
-0.005688476,
-0.05176814,
-0.03635809,
0.020988168,
-0.0075846342,
0.02264689,
-0.006022895,
-0.014901733,
-0.017858,
0.008460813,
0.0027154863,
-0.013423598,
-0.013671069,
-0.01985114,
0.026312126,
-0.02604459,
0.03178323,
0.013804837,
-0.047995888,
0.009738296,
0.02363677,
-0.02961619,
-0.013951981,
0.012152805,
-0.0015826403,
-0.0008594581,
0.008460813,
-0.006032928,
-0.0059727323,
-0.012493912,
0.0027405678,
0.0077719092,
0.0014538887,
0.004497942,
-0.0031652807,
0.0017055394,
-0.007611388,
0.009390499,
0.014567314,
0.010587721,
-0.016480193,
-0.022526497,
-0.010353628,
-0.014018865,
-0.018138913,
0.025308868,
0.0064542964,
-0.00017598826,
-0.013604186,
-0.018272681,
-0.010507461,
0.02501458,
-0.018459957,
-0.012808267,
0.02259338,
-0.01623941,
-0.0005534643,
-0.0021335965,
-0.021924542,
0.03140868,
0.008099641,
-0.005658378,
-0.0058055227,
0.003568256,
0.015597326,
0.028305266,
-0.01528966,
-0.0039127083,
-0.013818214,
-0.02209844,
0.018553594,
-0.024292232,
0.014273024,
-0.018727493,
0.030338537,
-0.022031557,
-0.02284754,
0.0087015955,
0.02081427,
0.0033876696,
0.00672852,
0.019757504,
0.18352942,
-0.0023743785,
-0.000531309,
0.029321902,
0.026151605,
0.017055394,
0.032425314,
-0.00080720504,
0.0125139775,
0.021857658,
0.022740526,
0.0034277998,
-0.022834163,
-0.001440512,
0.024773797,
-0.006588064,
-0.039434746,
-0.03427131,
0.0010258318,
-0.0061098444,
0.009651347,
-0.012119363,
0.00042157757,
-0.018553594,
0.016480193,
-0.00006019551,
-0.03140868,
-0.01163111,
0.03245207,
0.012560796,
-0.025937576,
-0.008119705,
0.015102385,
0.010975648,
-0.005477791,
-0.013436976,
-0.0008469174,
-0.018312812,
-0.011537473,
0.019677244,
0.00071732985,
0.012393586,
-0.031970505,
-0.011597668,
-0.024733666,
0.0041233925,
-0.01021986,
-0.0024546392,
-0.0006412494,
-0.01720254,
-0.029268395,
0.00084064703,
0.018540217,
0.023984566,
-0.005748671,
0.0006044632,
0.031355172,
-0.008674841,
0.00055179215,
0.039060198,
-0.027716689,
0.01038707,
-0.010641228,
0.0091697825,
-0.013082491,
0.0025198509,
-0.0027990912,
0.006173384,
0.0033525554,
0.0019647146,
0.026164982,
-0.004919311,
-0.035127424,
0.029214887,
-0.0063372497,
-0.01795164,
0.013858344,
0.01046733,
0.02056011,
0.019864518,
-0.017630596,
-0.005434317,
-0.024747044,
0.00028864582,
-0.027716689,
-0.008621335,
0.021429602,
-0.00573195,
-0.028519295,
0.022660265,
-0.00641751,
0.0012122707,
-0.008246785,
-0.021616876,
0.032559082,
-0.020292575,
0.007169954,
0.016587207,
0.01499537,
0.01129669,
-0.021376094,
0.094440065,
0.0058757504,
0.006297119,
0.025950953,
-0.00943063,
-0.005935946,
0.0054142517,
-0.017068772,
-0.00077752536,
0.003103413,
-0.02787721,
0.0104205115,
-0.013028984,
0.006982679,
0.0073505407,
0.029402163,
-0.039060198,
0.017563712,
-0.03301389,
0.020372836,
-0.01720254,
0.0009338665,
0.027034473,
-0.00274224,
0.018005146,
0.00036347218,
-0.0028342053,
-0.0038525127,
-0.025308868,
0.027636427,
-0.014620821,
0.00415349,
-0.007069628,
0.01204579,
0.0023927714,
0.003972904,
-0.0095443325,
-0.020506604,
0.01736306,
0.0064241984,
0.008969131,
-0.003551535,
0.01495524,
0.0067151436,
-0.023703653,
0.010246613,
-0.010373693,
0.019222433,
0.026178358,
-0.013222947,
-0.008220031,
0.006915795,
-0.010407135,
0.027743442,
-0.006427543,
-0.020118678,
-0.029937234,
0.0013067442,
0.016306294,
-0.02205831,
-0.009336992,
0.017563712,
-0.03365598,
-0.006882353,
0.025977707,
-0.16865444,
0.024907565,
0.024318986,
-0.020011663,
0.019249186,
0.006430887,
0.02221883,
0.015236152,
-0.038899675,
0.001320957,
0.01092214,
0.019837765,
-0.022887671,
-0.018914767,
0.02152324,
-0.0094506955,
-0.0036418284,
0.014553936,
0.026325503,
0.002230578,
0.0021988081,
-0.007096382,
0.0053406795,
-0.008634712,
-0.0050831763,
-0.006982679,
-0.012473848,
0.0025783742,
-0.010266678,
0.005869062,
-0.026499402,
0.015196022,
0.015102385,
-0.014246271,
0.0009890457,
0.019396331,
-0.0043942723,
0.0045079747,
0.008380553,
0.027422398,
0.026325503,
0.02097479,
0.01262768,
0.00010032585,
-0.045454297,
0.014366662,
0.015811354,
0.006310496,
-0.007959184,
0.007651518,
-0.001973075,
-0.02870657,
0.013189505,
0.012112674,
0.028760077,
0.0005438497,
0.003956183,
-0.010741554,
-0.006397445,
0.00448791,
0.0027205027,
-0.008741726,
0.022526497,
0.003101741,
0.0018660608,
-0.037588753,
-0.014594067,
-0.023168582,
-0.02264689,
0.008233408,
-0.018553594,
-0.008240096,
0.006089779,
-0.025777055,
-0.006567999,
0.032933634,
0.006989368,
0.015089008,
0.018138913,
0.0068689766,
0.002658635,
0.010320186,
-0.00905608,
0.0070896936,
-0.005354056,
0.034565598,
0.008714972,
0.0046718405,
0.0032505575,
-0.018031899,
0.004952753,
-0.024974449,
-0.0033408508,
-0.025322245,
0.013778083,
0.0044277143,
0.002692077,
-0.004648431,
0.021496486,
-0.025241984,
0.003879266,
-0.012634369,
-0.011871892,
-0.0051065856,
0.05476454,
-0.019249186,
-0.008995884,
0.0024646716,
0.026887327,
-0.003412751,
-0.020961415,
0.010574345,
0.006741897,
0.02389093,
0.0047587897,
0.00045857273,
-0.0073037217,
-0.016761106,
-0.0025131626,
-0.015918368,
0.06672338,
0.012768136,
0.0011729765,
0.014433546,
-0.017670726,
-0.028171498,
-0.10958258,
-0.038739156,
0.022700395,
0.0038558568,
-0.011517407,
0.035207685,
-0.01238021,
0.021616876,
0.016814612,
0.017215915,
0.0011069286,
-0.02114869,
0.0033910137,
-0.02130921,
0.03817733,
0.009744984,
0.020011663,
-0.0026803722,
-0.029054366,
0.040852685,
-0.003601698,
0.00959784,
-0.00826685,
-0.029696452,
-0.01250729,
-0.007444178,
-0.009196537,
0.0012097625,
0.011269937,
0.011403705,
0.027743442,
-0.01870074,
0.025616534,
0.0106077865,
-0.01823255,
0.00013502187,
-0.029963987,
-0.038953185,
0.03140868,
-0.037829533,
-0.0017590466,
-0.019596983,
0.01761722,
-0.022580005,
-0.0055848057,
-0.015115761,
-0.01856697,
-0.003273967,
0.025348999,
0.01848671,
0.012527354,
-0.024987824,
0.015530442,
-0.021884412,
-0.0021118592,
-0.015196022,
0.016292918,
-0.01570434,
-0.017349683,
-0.018580347,
0.000377476,
0.0061031557,
-0.029642945,
0.025456013,
0.0069759907,
-0.024813928,
-0.0029813498,
-0.019423084,
0.020734008,
-0.007444178,
-0.04079918,
-0.01196553,
-0.0059727323,
0.016440062,
-0.03202401,
-0.002039959,
-0.03020477,
-0.04465169,
-0.0021653662,
-0.01757709,
-0.02193792,
-0.013316585,
0.018299434,
-0.0074040475,
-0.011483965,
0.008668154,
0.0017021953,
0.020827647,
-0.0066348827,
-0.018312812,
0.017496828,
0.01345704,
0.0059894533,
-0.022580005,
0.013022295,
-0.01698851,
-0.02596433,
0.0036752704,
0.014179387,
-0.00018999208,
-0.016292918,
-0.016961757,
-0.061372668,
0.008347111,
0.032639343,
-0.019168926,
0.008126394,
-0.0005041374,
0.03547522,
-0.00442437,
0.005160093,
0.0032338365,
-0.012580861,
0.016587207,
-0.0066348827,
-0.011524096,
-0.022941178,
0.0005543003,
0.027957471,
0.003735466,
0.049012523,
0.02231247,
-0.0022021525,
-0.019008404,
0.009611216,
0.014874979,
-0.020747386,
0.007992626,
-0.0021486452,
0.0033525554,
-0.011711371,
0.015851485,
0.0040531643,
-0.021242326,
-0.0011888613,
0.010915453,
-0.022580005,
0.011055909,
-0.0027138141,
0.024666782,
0.0165337,
0.010788373,
-0.0045581376,
-0.029883727,
0.015115761,
-0.008922312,
-0.010005832,
-0.0064877383,
-0.038444865,
0.020921284,
0.004340765,
-0.023168582,
-0.014848226,
0.0031335107,
0.010828503,
-0.048878755,
-0.03277311,
0.00049452286,
-0.014901733,
-0.012065856,
-0.02629875,
-0.036304582,
0.017429944,
0.007992626,
0.007497685,
0.021041675,
0.00091463735,
-0.010708112,
0.017309554,
-0.0013226292,
0.001989796,
0.0146074435,
0.004785543,
0.002730535,
0.00764483,
0.005688476,
-0.00069433847,
0.0029412196,
-0.002690405,
0.019369578,
-0.029054366,
-0.0019948124,
-0.0007461735,
-0.01200566,
-0.020586865,
0.007129824,
0.0043775514,
0.051152807,
-0.025322245,
0.017135656,
-0.009457383,
0.013276454,
-0.006915795,
-0.013651004,
-0.0018560282,
0.0062001375,
0.018005146,
0.04299297,
0.013329961,
-0.022031557,
-0.004922655,
-0.015503688,
-0.005160093,
0.03095387,
-0.020640371,
-0.02201818,
0.0007654026,
-0.013490482,
-0.010112845,
-0.033843253,
-0.030017495,
0.0068188137,
0.028867092,
0.025603157,
0.014339908,
0.0017958328,
-0.0056149033,
0.02031933,
-0.0049259993,
-0.0123267025,
-0.018179044,
0.021335965,
0.016373178,
0.028358774,
0.030392043,
-0.0071231355,
0.019918025,
0.01769748,
0.026980964,
-0.00031456334,
0.024359116,
0.00091463735,
0.0057754247,
-0.0046149893,
-0.01615915,
0.014928486,
-0.011149546,
-0.026138227,
-0.016506946,
0.023248844,
-0.01607889,
0.064155035,
0.015851485,
-0.03269285,
-0.013697823,
0.0034879954,
0.02114869,
-0.0114505235,
0.024747044,
-0.015062254,
-0.010059339,
0.020573488,
-0.008929,
0.034324817,
-0.045052994,
-0.029937234,
0.019396331,
0.013978736,
0.021068428,
0.00014892119,
0.0018660608,
0.023355858,
-0.022954555,
0.018620478,
-0.02625862,
-0.02446613,
-0.023957813,
0.033040646,
-0.012079232,
-0.023650147,
-0.024171842,
-0.0064409194,
-0.0007562061,
-0.018714115,
-0.014874979,
0.039648775,
-0.0019797634,
-0.0025231952,
-0.0012599254,
0.004334077,
0.0112632485,
0.00822672,
0.021830905,
-0.027689934,
-0.020359458,
-0.011162923,
-0.009089522,
-0.013557366,
-0.016199281,
-0.0043474534
] |
CCAAT/enhancer-binding proteins, C/EBPalpha and C/EBPbeta, are required for fat cell differentiation and maturation. Previous studies showed that replacement of C/EBPalpha with C/EBPbeta, generating the beta/beta alleles in the mouse genome, prevents lipid accumulation in white adipose tissue (WAT). In this study, beta/beta mice lived longer and had higher energy expenditure than their control littermates due to increased WAT energy oxidation. The WAT of beta/beta mice was enriched with metabolically active, thermogenic mitochondria known for energy burning. The beta/beta allele | [
-0.03904725,
-0.03699639,
-0.009282829,
-0.033812165,
-0.03567413,
0.01721641,
-0.027821502,
0.008507011,
-0.031518444,
-0.019645058,
-0.008237162,
0.007893103,
0.01727038,
0.030924775,
0.0032415693,
-0.00036429707,
0.02292373,
0.010949151,
-0.002659706,
0.015071105,
-0.03270578,
0.014949673,
-0.0017025828,
-0.011050344,
-0.0063650794,
-0.014760777,
0.00018193772,
-0.04622525,
-0.021115737,
-0.025554765,
0.024542829,
-0.00328542,
-0.018012466,
-0.0029919583,
-0.002970033,
-0.007636746,
-0.004685265,
-0.011178523,
0.046090327,
-0.010928912,
0.027713563,
0.03362327,
0.0021351855,
0.013937736,
-0.010638824,
-0.004405296,
-0.0042737443,
-0.010173333,
0.002148678,
0.008763368,
-0.00789985,
0.027227834,
-0.0067766,
-0.01689259,
-0.03313754,
0.007562537,
0.001408278,
0.014072661,
0.0027339146,
-0.0022464986,
-0.0053835013,
0.0011738461,
-0.014099646,
-0.0077379397,
-0.0057208133,
0.00228023,
0.009579664,
0.016096534,
0.004037626,
0.013040486,
0.023598354,
-0.0052013528,
-0.013843289,
0.0067057647,
0.023787249,
-0.00635496,
-0.028010398,
0.021223677,
-0.005676963,
0.0005270502,
0.043472786,
0.0027035566,
-0.0025146618,
0.029467586,
0.018228346,
-0.023207072,
-0.009809036,
0.0115967905,
-0.015597312,
-0.00069148984,
0.030600954,
0.010928912,
0.03437885,
0.014868718,
-0.016393369,
0.01165076,
0.015664775,
0.005801768,
-0.014275048,
-0.011981326,
-0.017742617,
0.013310336,
-0.017189424,
-0.01917282,
-0.017769601,
0.0077514322,
-0.023395967,
0.0012210698,
0.035377294,
0.00022030697,
-0.011684491,
0.04258228,
0.006968868,
-0.045901433,
0.008507011,
0.0020963948,
-0.004789832,
-0.0050259503,
-0.00763,
-0.000884601,
0.015475879,
0.03796785,
0.024556322,
-0.005822007,
0.00029472646,
0.019645058,
-0.009836021,
-0.011313448,
-0.0071510165,
-0.01743229,
0.019213298,
-0.024839664,
0.026661148,
0.013573439,
-0.03602493,
0.00344227,
-0.015003642,
-0.010949151,
-0.017175931,
-0.025514288,
-0.0134520065,
0.01960458,
-0.01322938,
-0.00019711677,
-0.016190981,
0.034513775,
0.0151655525,
0.018997418,
0.0046380414,
0.008264147,
-0.026121449,
-0.009606649,
0.037698,
-0.002620915,
0.0037441645,
0.017027516,
-0.009404262,
0.012521026,
-0.00974832,
-0.028388187,
0.013080964,
-0.008925279,
0.0014420092,
0.006381945,
0.02520396,
0.018376764,
-0.008662174,
-0.021426065,
0.02949457,
-0.006803585,
-0.0044120424,
0.012176967,
-0.02633733,
0.033866134,
-0.015421909,
0.017769601,
-0.025230946,
0.020211741,
-0.021587975,
-0.014409973,
-0.00044314377,
0.0098967375,
0.01552985,
-0.00025677885,
0.0038892087,
-0.02220863,
0.010820973,
-0.01824184,
0.005886096,
-0.015651282,
0.015664775,
0.012480548,
0.0018197988,
-0.025487302,
-0.6394358,
-0.0035788815,
0.019118851,
-0.013067471,
-0.011138046,
0.024880141,
0.00999793,
0.0009444739,
-0.014167109,
0.029899346,
0.0053430237,
-0.0015634416,
0.020899858,
-0.017985482,
-0.020441113,
-0.01906488,
-0.020845888,
-0.01526,
0.012399593,
0.003953298,
-0.019240282,
0.01032175,
-0.023153102,
0.015610804,
0.0038925817,
0.020414129,
0.014302033,
-0.00023274535,
0.009174889,
0.030789848,
-0.0027693324,
0.0470348,
0.0049955924,
0.010078886,
0.04687289,
0.012487294,
0.0032449425,
0.0129258,
0.018025959,
0.019766489,
-0.019199805,
-0.006260513,
0.018808523,
0.0124400705,
-0.017081484,
0.017931512,
-0.0018214853,
0.027268311,
-0.0129595315,
-0.0078121484,
-0.005019204,
0.0038015074,
-0.047547515,
-0.011111061,
-0.012615473,
0.0035046728,
0.018997418,
-0.013074217,
0.017715631,
0.011886879,
-0.009957453,
0.026553208,
-0.0054779486,
-0.025838107,
-0.013485738,
0.005272188,
-0.008770115,
0.012156729,
0.0117654465,
0.0068373163,
0.017675154,
0.012143236,
-0.011104315,
0.03132955,
0.035943978,
0.010989629,
0.0077042086,
-0.0011240926,
-0.0042602518,
-0.0023898564,
-0.006769854,
0.008999487,
-0.0119341025,
0.003116764,
0.030654924,
-0.0062132888,
-0.0003027376,
-0.0010186826,
0.005997409,
-0.0036868213,
0.017297365,
-0.0072049866,
-0.013688126,
-0.01868709,
-0.012952785,
0.0031117043,
0.004745981,
-0.006277378,
0.004847175,
-0.016973546,
-0.026755596,
0.0099642,
0.0075692837,
-0.018403748,
0.010099124,
0.009073695,
-0.016379876,
-0.0071172854,
0.037401166,
-0.01955061,
0.00042100766,
-0.002678258,
-0.009937215,
-0.009701096,
-0.006877794,
-0.015948117,
0.00958641,
0.0039060742,
-0.003983656,
-0.02628336,
0.021412572,
-0.0003267711,
0.014544898,
-0.021358602,
-0.0034254044,
0.033056587,
-0.0067327498,
-0.008905039,
-0.016582264,
-0.015138567,
0.022019735,
-0.008749876,
0.0076502385,
-0.0181339,
0.013344067,
0.011603536,
0.004705504,
0.0060345135,
0.018511688,
-0.02933266,
-0.009991185,
-0.010827718,
-0.0022228868,
-0.0025973031,
-0.009093935,
0.0086891595,
0.004317595,
-0.0066450485,
0.014261556,
-0.00518786,
-0.009242352,
0.014275048,
-0.014032183,
0.009836021,
0.037347198,
-0.011333686,
-0.003312405,
-0.018565658,
-0.0064527807,
-0.008844323,
-0.02933266,
0.007393881,
0.0034152851,
0.008641936,
-0.0009158024,
-0.011772192,
0.0052215913,
0.01836327,
-0.039613932,
-0.022397524,
0.016123518,
-0.0148147475,
-0.021061769,
0.014976658,
-0.008372086,
0.021034783,
0.002106514,
-0.01477427,
-0.0074545974,
-0.011826162,
0.0069553754,
-0.0022937222,
-0.007272449,
-0.014180601,
0.045415703,
0.017256888,
0.010686047,
0.01586716,
-0.0015836803,
0.01509809,
-0.028172307,
0.023476923,
-0.0009233919,
0.018714076,
0.027956428,
-0.024178531,
0.02308564,
0.017769601,
0.020886365,
0.012615473,
0.006321229,
-0.030708894,
0.023611847,
-0.035215385,
0.030708894,
-0.05154129,
0.0034911803,
-0.015691759,
0.010328497,
-0.0105916,
-0.010780495,
0.017877541,
-0.008216923,
0.008149461,
-0.0061525726,
-0.0020289323,
-0.016285429,
0.0014259869,
0.014922688,
-0.026526224,
-0.012318638,
0.008189938,
0.017283872,
-0.014099646,
-0.00630099,
0.0062132888,
0.025946047,
0.013755588,
0.0020744693,
-0.017864048,
0.0007500978,
-0.0021959017,
0.0025618854,
-0.011347179,
0.0025079155,
-0.025069036,
0.03062794,
-0.010031662,
0.021088753,
0.0014546585,
0.015192538,
0.006378572,
0.007906596,
-0.005862484,
-0.003568762,
-0.007994297,
0.0022346927,
0.04007268,
-0.0035788815,
0.00066534814,
0.007960565,
0.02303167,
-0.023099134,
0.017796587,
0.008331609,
0.0005696358,
0.018727569,
0.0054779486,
0.032624826,
0.016582264,
0.040855244,
-0.0035249116,
-0.014234571,
-0.012419832,
0.006277378,
0.00012417302,
0.008668921,
-0.019469654,
0.004246759,
-0.0060614985,
-0.0351884,
0.0016890904,
-0.00577141,
-0.035107445,
0.020899858,
0.0054442175,
0.01689259,
0.017985482,
0.025649212,
0.0037171794,
-0.0037272987,
-0.035970964,
0.032489903,
0.0043681916,
-0.016960053,
-0.013276604,
-0.034405835,
-0.0051676217,
-0.017405305,
0.017958496,
0.004101715,
0.010254288,
0.007603015,
0.006071618,
-0.004850548,
0.007272449,
0.019793475,
-0.03149146,
0.031302564,
0.00736015,
0.015354447,
0.0010827718,
-0.010301512,
-0.012075773,
0.03578207,
0.012804368,
-0.0005843932,
0.0046043103,
0.0060345135,
-0.027794518,
-0.0041152076,
-0.029143766,
0.0038723429,
-0.005356516,
-0.004256879,
-0.0071510165,
0.009741574,
0.015057612,
0.033704225,
0.009019726,
-0.006209916,
-0.026580194,
-0.0057241865,
-0.004830309,
0.012595234,
0.034567744,
0.0025045425,
0.009235606,
-0.011212254,
0.0018737687,
-0.014531406,
-0.013087709,
0.008837577,
0.0042164014,
0.005521799,
0.0020829022,
0.0030577343,
-0.015300477,
0.0007378702,
0.003288793,
-0.004573952,
-0.050003145,
-0.001474054,
-0.016163995,
0.006692272,
-0.0003080081,
0.02231657,
0.028685022,
0.038156744,
0.006101976,
0.0031943456,
0.033812165,
-0.005913081,
-0.018295808,
-0.00037673546,
-0.0023932294,
-0.0012160102,
0.010841211,
0.029062811,
-0.029710451,
0.0026107957,
0.012939292,
0.009384023,
-0.0048674135,
0.021223677,
0.016379876,
0.024799187,
0.00910068,
0.011003121,
-0.003438897,
0.007461344,
0.0081966845,
0.0067293765,
0.00090736954,
0.030169195,
-0.01445045,
-0.016555278,
-0.011138046,
0.0024994826,
-0.0059265736,
0.005852365,
-0.021871317,
0.024043607,
-0.011576551,
-0.02075144,
-0.01764817,
0.013398036,
0.0050529353,
-0.0041421927,
-0.009485217,
-0.000726486,
-0.030789848,
-0.015988594,
-0.007974058,
-0.00657084,
-0.019118851,
-0.02520396,
0.0008538213,
0.0002951481,
0.022411017,
0.011839655,
-0.028981857,
-0.012224191,
0.032408945,
-0.0068204505,
-0.00014135486,
0.011205508,
-0.04606334,
0.016433846,
-0.01233213,
0.015772713,
-0.04066635,
-0.0081831915,
-0.0040477454,
0.010605092,
-0.01944267,
0.029845376,
-0.015300477,
0.014679823,
0.00092929485,
0.00018510001,
0.02645876,
0.011320194,
-0.020333175,
0.0044525196,
-0.0036024933,
-0.0014394794,
-0.013337321,
-0.009276083,
-0.004702131,
0.010827718,
-0.015421909,
0.0011839655,
-0.012703174,
-0.007130778,
0.00010583167,
0.012075773,
-0.017283872,
0.009518947,
0.027443713,
0.0066416753,
0.020562546,
0.0036868213,
-0.0024640649,
-0.006081737,
-0.030304119,
0.0060884836,
0.0017725751,
-0.028091352,
0.011853147,
-0.013222635,
0.001600546,
-0.007495075,
0.011967833,
-0.025217453,
0.013202396,
-0.012197206,
-0.029656481,
-0.036132872,
-0.00021883124,
-0.015111582,
0.013910751,
-0.0044693854,
0.025716675,
-0.02237054,
0.012986516,
0.01208252,
-0.017796587,
0.014194094,
-0.033812165,
-0.009276083,
0.027227834,
0.01181267,
0.010679301,
0.0183093,
0.0025163484,
-0.019105358,
-0.021250663,
-0.015894147,
-0.03964092,
0.0031437487,
-0.014086153,
0.04708877,
0.032085128,
0.027713563,
0.019564101,
0.020265711,
0.029143766,
0.009053457,
0.007124032,
-0.014356003,
0.022586418,
-0.008075252,
0.0085339965,
0.013910751,
-0.004870787,
0.01667671,
-0.018646613,
0.018835507,
0.015125074,
-0.014679823,
-0.016649725,
-0.0026968103,
-0.027349265,
-0.033434376,
0.009869752,
0.0012767264,
0.0057208133,
-0.029413616,
-0.011556312,
0.023544384,
0.013350813,
0.010463421,
-0.007427613,
0.013924244,
-0.032354977,
0.03589001,
-0.004681892,
-0.018039452,
0.00296666,
-0.03046603,
0.018700583,
-0.009647126,
0.0055015604,
0.02102129,
-0.0023898564,
0.004415415,
-0.028361201,
0.0021132603,
-0.0012421518,
-0.022073705,
0.0024775574,
-0.0037576568,
-0.009390769,
-0.001095421,
-0.040909212,
-0.02927869,
-0.014544898,
-0.008156206,
0.000519039,
-0.036429707,
0.028550096,
0.0032027785,
-0.0299803,
0.013775826,
-0.0061188415,
0.044983942,
-0.014194094,
0.057046223,
0.03470267,
0.015246507,
-0.019564101,
-0.02177687,
-0.012399593,
0.015556835,
0.021061769,
0.011630521,
-0.010213811,
0.0009815783,
-0.021817347,
0.012622219,
-0.03807579,
-0.024799187,
0.03232799,
-0.043688662,
0.0076434924,
0.003818373,
0.013782573,
-0.03580905,
-0.009336799,
-0.021007799,
0.0031977186,
0.008001043,
-0.028685022,
-0.016852112,
0.017796587,
0.0026158553,
0.009073695,
-0.0049753534,
0.0042164014,
0.007879611,
-0.027686577,
-0.020360159,
-0.0093772765,
0.0122714145,
0.02601351,
-0.0099642,
-0.01080748,
0.0032280767,
0.013344067,
-0.012588488,
-0.009647126,
0.007333165,
0.040153634,
0.03046603,
0.00042627816,
0.014005199,
0.0009942275,
0.014436958,
0.011286463,
-0.015570327,
-0.030331105,
-0.016029071,
0.0025230946,
0.019267267,
0.0068912865,
-0.030762864,
-0.0021706035,
-0.016879098,
0.0041826703,
-0.041233033,
-0.021736393,
0.0045199823,
-0.05094762,
0.013532962,
0.013883767,
-0.0036632095,
0.017864048,
0.025595242,
0.024529336,
-0.010186826,
0.021466542,
-0.025055543,
0.028064366,
-0.014059168,
0.028307231,
-0.008149461,
0.0103892125,
-0.026890522,
-0.003327584,
-0.009242352,
0.0012404653,
-0.018889477,
-0.015826683,
-0.0023122744,
0.02743022,
0.01520603,
0.0052991733,
0.0148282405,
0.0060952296,
0.023099134,
-0.0109086735,
-0.0044120424,
0.006692272,
-0.018430734,
0.0065843323,
0.019699028,
0.015246507,
-0.0183093,
-0.02743022,
-0.017121963,
0.021763377,
-0.0080145355,
-0.0041489387,
-0.018228346,
0.029197736,
-0.007555791,
0.004543594,
0.008675667,
-0.02188481,
-0.009667365,
0.016474323,
0.003953298,
-0.00034532326,
-0.019860936,
0.0074545974,
-0.019779982,
0.018120406,
-0.039020263,
-0.009235606,
-0.019078372,
-0.016298922,
-0.052809585,
0.015691759,
-0.021709407,
0.017675154,
0.0022009616,
-0.009613395,
-0.018889477,
0.0029447346,
-0.03508046,
-0.026823059,
-0.0050461893,
0.023746772,
-0.004314222,
0.0019193059,
0.008142714,
0.021749884,
0.0032247037,
-0.004270371,
-0.025703182,
-0.011799177,
-0.005211472,
-0.021979257,
0.020441113,
0.007603015,
-0.013074217,
-0.023274535,
0.031464472,
-0.011610283,
-0.0042164014,
0.015570327,
-0.016325906,
0.013134933,
-0.015381432,
0.03812976,
0.008965756,
0.007022838,
0.030546984,
-0.026202405,
0.015826683,
0.023315012,
-0.008736383,
0.0063751987,
-0.006607944,
0.013721856,
0.015934624,
-0.0026377807,
-0.020225234,
-0.034999505,
-0.016123518,
0.015421909,
0.009943961,
0.018471211,
-0.008493518,
-0.0066450485,
0.02335549,
-0.021871317,
-0.02150702,
-0.011144792,
-0.0045233555,
-0.009667365,
-0.0076839696,
0.009809036,
-0.011637268,
0.004202909,
-0.0046043103,
-0.029116781,
-0.013472245,
-0.0051136515,
0.00089640694,
-0.0034135985,
0.0123861,
-0.0074208663,
-0.022761822,
-0.00947847,
0.007164509,
-0.0076502385,
-0.013047232,
0.0019429177,
-0.0058085145,
0.0052856808,
-0.0049719806,
0.0022464986,
-0.011785685,
-0.014382988,
-0.004287237,
-0.025932554,
0.011738461,
0.020211741,
0.18479307,
-0.020144278,
-0.010922166,
0.02330152,
-0.0081966845,
-0.019699028,
-0.003909447,
-0.0057545444,
0.0050563086,
0.010713032,
0.0007277509,
0.02313961,
-0.024961095,
0.007326419,
0.009620141,
0.005049562,
-0.027308788,
-0.0055015604,
-0.022991193,
-0.007441105,
0.008722891,
-0.008115729,
0.020117294,
-0.007906596,
0.037185285,
0.0023594983,
-0.022411017,
0.008500265,
0.018295808,
0.002686691,
-0.0319502,
0.013290097,
-0.020265711,
-0.000397185,
-0.00980229,
0.013951229,
-0.023112625,
0.0050057117,
0.016663218,
-0.0017590827,
-0.016474323,
0.021412572,
-0.022950716,
-0.0073668966,
-0.0050461893,
0.024866648,
-0.005592635,
-0.00746809,
-0.0018771419,
0.0026462134,
-0.01520603,
0.017513245,
0.028712006,
0.020292696,
-0.013168665,
-0.00094363064,
0.008621697,
0.004432281,
0.0015836803,
0.033704225,
-0.0247722,
-0.0073736426,
-0.03270578,
0.025757153,
-0.016339399,
0.031464472,
-0.0048370557,
0.00038010857,
0.015003642,
-0.015732236,
0.01640686,
-0.018983925,
-0.020238725,
0.018754553,
-0.0024202145,
-0.019321237,
0.018714076,
0.034621716,
-0.00076527684,
0.01520603,
0.02237054,
-0.021277647,
-0.028631052,
0.0076097613,
-0.0036159859,
-0.036942422,
0.026701625,
-0.01148885,
-0.01775611,
-0.026850043,
0.0071510165,
-0.008142714,
-0.010449929,
-0.0033798672,
0.025109513,
-0.02161496,
-0.0206435,
0.0010608466,
-0.023503907,
-0.003189286,
-0.028469142,
0.056992255,
0.010099124,
0.01890297,
-0.00006635561,
-0.0077446857,
-0.015273492,
0.002551766,
0.0021722899,
0.01656877,
-0.010618585,
-0.043499768,
-0.000011423812,
-0.008102236,
-0.021264154,
0.0122984,
0.017297365,
-0.023072148,
0.015759222,
-0.0034776877,
-0.014585376,
-0.047547515,
0.023207072,
0.021061769,
-0.009330053,
0.014585376,
-0.01148885,
-0.00011205087,
-0.032139096,
-0.04177273,
-0.013074217,
-0.013843289,
-0.013701618,
-0.004678519,
0.0012531144,
-0.0081831915,
0.005319412,
-0.0247722,
-0.02183084,
0.04800626,
-0.018471211,
-0.0048572943,
0.031356532,
-0.0013290097,
0.019523624,
-0.017837064,
0.018700583,
0.01818787,
-0.000102353144,
-0.013519469,
-0.04150288,
-0.00883083,
0.0035417771,
-0.016501307,
0.025433334,
-0.0076502385,
-0.0024556322,
-0.04414741,
-0.0132833505,
-0.0031302564,
-0.024313457,
-0.0032668677,
-0.0030341223,
-0.014733793,
0.0045570866,
-0.0042669983,
-0.17130058,
0.0072117327,
0.0055892617,
-0.014801255,
0.013856782,
0.023126118,
-0.013202396,
-0.017405305,
-0.006793466,
-0.0072454643,
0.007326419,
0.004621176,
-0.03958695,
0.004071357,
0.011367418,
0.0030577343,
-0.026067479,
0.03219307,
0.0040005217,
0.0005072331,
0.035107445,
-0.020360159,
0.029008841,
-0.010800733,
0.013580185,
0.03362327,
0.008034774,
-0.013215888,
-0.0030189434,
-0.0240571,
-0.0088713085,
0.0053160386,
0.024259487,
0.017148947,
0.0068710474,
-0.010962644,
-0.009080442,
-0.018592643,
0.0026040494,
0.018916463,
0.050596815,
0.023288028,
-0.021695914,
0.0032398829,
-0.0010136229,
0.034837592,
0.0067833466,
-0.0018063063,
0.035701115,
-0.009080442,
0.0017025828,
-0.010989629,
0.018511688,
0.024839664,
0.049679328,
-0.0071105394,
0.009809036,
0.022775313,
-0.011198762,
-0.008230415,
-0.0074073737,
-0.01504412,
0.03732021,
-0.013937736,
0.022060212,
-0.026782582,
-0.0135532,
0.014909195,
-0.008783607,
-0.01445045,
-0.024920618,
-0.011826162,
0.0063718255,
-0.02367931,
0.020805411,
0.030735878,
-0.009444739,
-0.0000071283534,
0.016379876,
-0.005160875,
-0.034891564,
0.0098832445,
-0.028388187,
-0.026553208,
-0.012406339,
0.017189424,
0.016541786,
0.017891034,
0.00657084,
-0.012973024,
0.0040882225,
-0.013134933,
-0.011340433,
-0.03062794,
0.0151520595,
0.013647648,
-0.009795544,
-0.0071105394,
0.0063954373,
0.017783094,
0.03551222,
-0.027268311,
-0.011563059,
-0.0060277674,
0.04242037,
0.00066787796,
-0.034999505,
0.0049955924,
0.049463447,
0.006709138,
0.010308258,
0.004793205,
-0.0025585124,
0.013121441,
0.0046481607,
-0.018093422,
-0.016906083,
-0.025608735,
0.0030054508,
-0.035863023,
0.054752503,
0.003646344,
0.00023443191,
0.019091865,
-0.0051946063,
-0.018214853,
-0.11959738,
-0.050326966,
-0.024637276,
0.012433324,
-0.004739235,
0.008817338,
-0.0005540351,
0.03834564,
-0.0037070601,
0.030250149,
-0.014895703,
-0.015448894,
0.003562016,
0.007225225,
0.013020247,
-0.0060581253,
0.03219307,
0.013377798,
-0.030493014,
0.039236143,
0.013026994,
-0.01820136,
0.0038082537,
-0.026472254,
0.016771158,
-0.014909195,
-0.025379363,
0.009249098,
0.010436436,
-0.0019159327,
0.0031521816,
-0.017175931,
0.009620141,
-0.0008057543,
-0.0159751,
-0.025865093,
-0.0117519535,
-0.01574573,
0.018822016,
-0.0023814235,
0.008378833,
0.0042838636,
0.00015569062,
0.00005813363,
-0.012467056,
0.007852626,
-0.009174889,
-0.018498195,
-0.01118527,
-0.012433324,
-0.01585367,
-0.025865093,
-0.013384544,
-0.0011485477,
0.02069747,
-0.025986524,
0.026566701,
0.024070593,
0.003933059,
-0.012149982,
0.016541786,
0.004762847,
-0.01955061,
-0.0018889478,
0.015948117,
-0.038642474,
-0.0030003912,
-0.02645876,
0.024380919,
-0.027686577,
-0.010335243,
0.032408945,
0.004341207,
-0.0021368722,
-0.020414129,
0.0063077365,
-0.012723412,
-0.005818634,
0.009147904,
-0.019564101,
-0.009977692,
-0.012581741,
0.0151520595,
-0.0117654465,
0.0015381431,
-0.001302868,
0.0059670513,
0.015192538,
0.00040287714,
-0.012878576,
-0.016852112,
0.035269354,
0.024542829,
-0.030061254,
-0.026310343,
0.013580185,
0.011529327,
-0.020265711,
0.024907125,
0.0026259748,
-0.010895181,
-0.011610283,
-0.046845905,
0.025028558,
-0.011009867,
-0.011050344,
0.0061964234,
-0.018322794,
0.003818373,
-0.010847957,
-0.00910068,
0.00736015,
-0.0073736426,
0.022424508,
-0.0001660208,
-0.03292166,
-0.0029868986,
-0.011913864,
0.010874942,
0.0041658045,
0.032759752,
0.017148947,
0.0057849027,
0.013209142,
0.027983412,
-0.021061769,
-0.016798142,
-0.006496631,
-0.026769089,
0.01488221,
-0.012069027,
0.002978466,
0.0014074348,
-0.027659593,
0.0087026525,
0.015570327,
-0.0094245,
0.0015482625,
-0.015813192,
0.018619629,
0.02340946,
0.000588188,
-0.004121954,
-0.025554765,
0.009336799,
0.006823824,
-0.0052856808,
-0.0026580193,
-0.030897789,
-0.0036598362,
0.01086145,
0.007906596,
0.023827728,
0.019321237,
0.02699846,
-0.028765976,
-0.0007825641,
0.0010557869,
-0.0062571396,
0.001988455,
-0.010611839,
-0.01818787,
0.018781537,
0.035836037,
0.021763377,
-0.0029970182,
0.001345032,
0.0015406731,
-0.004729116,
-0.0081966845,
0.0038723429,
-0.03872343,
-0.021952271,
0.021857824,
0.022464987,
0.006378572,
0.004533475,
-0.004297356,
-0.02465077,
-0.006297617,
-0.0015448894,
0.02400313,
0.0129460385,
-0.00038643318,
-0.026755596,
0.0021166333,
0.024084084,
-0.0029885853,
-0.00719824,
0.0025821242,
-0.013013501,
0.016636234,
0.008756623,
0.012467056,
0.0018636493,
0.01825533,
0.016150504,
0.026850043,
0.010976136,
0.010173333,
-0.00376103,
0.022991193,
-0.009073695,
0.0028637797,
-0.0075085675,
-0.012993262,
-0.01743229,
0.015381432,
-0.010814226,
-0.027794518,
-0.012075773,
-0.00487416,
0.017337842,
0.013431768,
-0.009316561,
0.0053632623,
-0.016595755,
0.02069747,
0.0011991445,
-0.005177741,
-0.011846401,
0.017175931,
0.022532448,
0.0034102253,
-0.010254288,
0.0017202918,
-0.0040140143,
-0.0041084616,
0.048680883,
-0.010240795,
0.013215888,
-0.009161397,
0.014841733,
-0.012237683,
-0.01324962,
-0.0048100706,
-0.00831137,
0.003592374,
0.013134933,
0.01754023,
-0.009255844,
0.09293623,
0.01743229,
-0.011907117,
-0.0023696176,
-0.012689682,
0.036213826,
0.018592643,
0.017094977,
-0.012372608,
-0.010874942,
-0.0047999513,
-0.048977718,
0.023922175,
-0.04660304,
-0.015948117,
0.02699846,
0.0076232534,
0.0175942,
0.008480026,
-0.032786738,
0.011124553,
-0.014234571,
0.011778939,
0.0001901597,
-0.049166612,
-0.0024168412,
0.045172837,
0.008884801,
0.0076839696,
-0.01028802,
-0.014909195,
-0.004661653,
-0.031032713,
0.003538404,
0.022532448,
-0.02699846,
0.0037711493,
-0.007906596,
0.032354977,
0.023922175,
0.023045164,
-0.025069036,
-0.0018754553,
-0.011873386,
0.02231657,
0.011954341,
-0.02150702,
-0.008756623,
-0.029629495
] |
The search for target genes involved in unbalanced acquired chromosomal abnormalities has been largely unsuccessful, because the breakpoints of these rearrangements are too variable. Here, we use the example of dicentric chromosomes in B cell precursor acute lymphoblastic leukemia to show that, despite this heterogeneity, single genes are targeted through a variety of mechanisms. FISH showed that, although they were heterogeneous, breakpoints on 9p resulted in the partial or complete deletion of PAX5. Molecular copy number counting further delineated the breakpoints and facilitated cloning with long-distance inverse PCR. This approach identified 5 fusion gene partners with PAX5: LOC392 | [
-0.035877954,
0.023428066,
0.029778969,
-0.03126394,
-0.03911307,
0.029009964,
-0.013497324,
-0.008611505,
-0.037309892,
0.005492403,
0.0046703657,
0.012018982,
0.0070469817,
0.013099563,
-0.0023782735,
0.018137857,
0.038184963,
-0.0041367044,
-0.009612534,
-0.015552417,
-0.048022896,
0.016135799,
0.007981718,
-0.004952112,
-0.013503953,
0.03444602,
0.030229762,
-0.031078316,
-0.02516495,
-0.013020012,
0.023268962,
0.025708556,
-0.0015305475,
-0.00036337037,
-0.027843202,
-0.017779874,
0.01691806,
-0.015101623,
0.020007329,
-0.025602488,
0.018177634,
0.01881405,
-0.020007329,
0.0027113976,
-0.0055852137,
-0.0075508114,
-0.0008187227,
-0.006974059,
-0.016175574,
0.013510582,
-0.0018131228,
0.0010118021,
-0.035294574,
0.019689122,
-0.009559499,
-0.010335132,
0.026795767,
0.021677922,
-0.019172033,
-0.0068215844,
-0.016096022,
-0.008571729,
-0.012509553,
0.020882402,
-0.026358232,
-0.0071530514,
0.009963889,
0.0016407601,
0.014717122,
-0.012582475,
0.039325207,
0.013828791,
0.016811991,
0.0060857283,
0.010355019,
-0.01791246,
-0.011753809,
-0.0031953389,
-0.0284531,
0.002161163,
0.02588092,
-0.007902166,
-0.0022241415,
0.014518241,
0.005760891,
-0.012496294,
0.002539035,
-0.002290435,
0.0045941286,
0.020033848,
0.011992465,
0.030786626,
0.019370914,
0.0018495842,
-0.027127234,
0.013364737,
0.005671395,
0.024594828,
0.0026600203,
-0.02516495,
-0.011561559,
-0.0075773285,
-0.018588653,
-0.016586592,
-0.026596887,
-0.015300502,
0.011826731,
-0.013218892,
0.0035798403,
0.0009314214,
-0.020577453,
0.013053158,
0.0006579614,
-0.018933378,
0.03444602,
-0.036169644,
-0.0067453473,
0.0015230895,
-0.021014988,
-0.00035984852,
0.031608663,
0.035877954,
-0.020670263,
-0.031476077,
0.010958289,
-0.017965496,
-0.03054797,
-0.002727971,
-0.023812568,
-0.015751297,
0.008333073,
0.012052129,
0.01124998,
-0.0017335708,
-0.037999343,
-0.010176027,
0.01592366,
-0.023428066,
-0.011296385,
-0.041287493,
0.005167566,
0.02855917,
-0.008750721,
-0.014982294,
0.0044847443,
0.019755416,
-0.00592331,
0.005744318,
-0.004265976,
-0.008227004,
-0.0021412747,
0.010706374,
0.023812568,
0.004159907,
0.012509553,
0.008644652,
-0.004511262,
0.017978754,
-0.03076011,
-0.027816685,
-0.0034870296,
0.011581446,
0.003742259,
0.026225645,
0.019583052,
0.028824344,
-0.008863419,
-0.003349471,
-0.0052007125,
-0.014717122,
0.0023650147,
0.0027942641,
-0.029275138,
0.0018661575,
-0.006894507,
-0.0072193444,
0.013006753,
0.0074778884,
-0.024250103,
0.006629334,
-0.003061095,
-0.004328955,
-0.008293296,
-0.009486577,
-0.022645805,
0.007875648,
0.010626822,
-0.023229185,
-0.0071596806,
-0.013590135,
-0.010726262,
0.011866508,
0.020617228,
-0.0043621017,
-0.6342947,
0.000006881818,
0.0061453925,
-0.0031439615,
0.0015504354,
0.050886765,
-0.003861587,
-0.00024238502,
-0.017832909,
0.013424401,
-0.020855885,
0.015989954,
0.009539612,
-0.007749691,
-0.031025283,
-0.033915672,
0.0096257925,
-0.013464177,
0.030919213,
0.017488183,
-0.0067122006,
0.0035002884,
-0.014279585,
0.018482583,
0.0037588323,
-0.00017153402,
0.033783086,
-0.0033759882,
0.017209752,
0.028240962,
-0.03412781,
0.008425883,
-0.034180846,
-0.00014822776,
0.05274298,
0.016904801,
-0.0023998187,
0.02369324,
0.019689122,
0.04070411,
0.0024860003,
0.0018429548,
0.03144956,
0.0018495842,
-0.01114391,
0.017527958,
0.0026600203,
0.007285638,
0.0024279936,
-0.005903422,
0.018495841,
-0.009566129,
-0.012562588,
-0.026291938,
-0.0071663097,
0.00042199853,
0.016785473,
-0.023229185,
0.022632545,
-0.006596187,
-0.0114621185,
0.01711694,
-0.014650828,
-0.0035566376,
0.011057729,
-0.0012877481,
-0.0016059561,
-0.008531952,
0.017952235,
0.014955777,
0.026093058,
0.037575066,
-0.01722301,
0.004368731,
0.020020587,
0.010799184,
-0.0054592565,
0.0025092028,
-0.0029732562,
0.010978177,
0.006834843,
-0.021452524,
-0.02686206,
0.00736519,
0.033570945,
0.010606934,
-0.025642263,
0.033995222,
-0.009267809,
-0.028426584,
-0.0037754057,
0.0007561584,
-0.0096257925,
-0.03911307,
-0.030521452,
0.023043564,
0.0063475873,
0.009513094,
0.014703862,
-0.052398253,
-0.019278103,
-0.028956931,
0.011879766,
-0.0023335256,
0.0058503873,
-0.005286894,
-0.0075706993,
-0.013987894,
0.0284531,
-0.02496607,
-0.0033328976,
-0.020219468,
-0.010195916,
0.0013987895,
0.008909824,
-0.014597793,
0.00040956854,
-0.0013449261,
-0.019463724,
-0.010288727,
0.019331137,
-0.003924566,
0.006009491,
-0.04857976,
0.009400396,
0.0071861977,
-0.011362678,
-0.011853249,
0.020471383,
-0.007511035,
-0.007212715,
-0.02040509,
0.0018164375,
-0.022579512,
0.023547394,
-0.011236721,
0.01722301,
0.0050250352,
0.0023600429,
-0.022632545,
-0.03341184,
-0.0058503873,
0.008439142,
0.01959631,
-0.00512779,
-0.010739521,
-0.023971671,
-0.007994977,
0.011210203,
-0.008001606,
0.012807873,
-0.007146422,
-0.025496418,
0.010620193,
-0.0007627877,
-0.015711522,
-0.0068149553,
-0.029301656,
-0.01084559,
-0.031396527,
0.008405996,
0.00056680804,
-0.0012836048,
-0.0022108827,
-0.007988348,
-0.008465659,
0.007855761,
0.020829367,
-0.010480977,
-0.0054294243,
0.0043256404,
-0.029116035,
-0.023268962,
0.015685003,
-0.0005489917,
0.0065332083,
-0.006128819,
-0.005267006,
0.012496294,
-0.0056780246,
0.0018562134,
-0.014372395,
-0.022460183,
-0.00081499375,
0.027896237,
0.019026188,
0.0075375526,
0.0026865376,
-0.0046902536,
0.03664696,
-0.014624311,
0.018920118,
-0.02139949,
0.020577453,
0.02378605,
-0.0035301202,
-0.005008462,
0.010328502,
-0.004309067,
0.036169644,
0.035055917,
-0.016175574,
-0.0035897843,
-0.0011377594,
0.009334102,
-0.05406885,
-0.0033610722,
-0.008896566,
-0.03802586,
0.0086380225,
-0.008014864,
-0.0049421685,
-0.0005514777,
-0.003543379,
0.009811414,
-0.007345302,
0.014253068,
0.0056780246,
0.012297414,
-0.0053962776,
-0.006854731,
0.01682525,
0.014253068,
0.007444742,
0.0011095847,
-0.002693167,
0.016851766,
0.010215803,
0.01034839,
-0.0066193896,
0.004597443,
0.027312856,
0.00463059,
0.017899202,
0.0045145764,
0.012290785,
0.013550359,
-0.0042162566,
0.03693865,
-0.007252491,
0.006834843,
0.016957836,
0.007994977,
0.004063782,
0.0033478136,
-0.004547723,
0.021651404,
0.02695487,
-0.010368278,
0.019278103,
-0.016082764,
-0.008565099,
-0.024316397,
0.0095329825,
0.025827885,
-0.008631392,
0.004607387,
0.0134376595,
0.058656346,
0.0036859096,
0.003732315,
-0.01263551,
-0.013563617,
-0.010122993,
-0.008531952,
0.017262785,
0.014955777,
0.006993947,
-0.01811134,
0.020842625,
-0.012834391,
-0.01650704,
0.012728321,
-0.032298114,
0.018973153,
0.0007341987,
-0.013053158,
0.020617228,
0.02219501,
0.0015346907,
-0.020749815,
-0.028824344,
0.04428395,
0.029248621,
-0.0048990776,
-0.012423372,
-0.023640204,
0.016931318,
-0.025562711,
-0.008445771,
0.019927777,
0.0013242094,
-0.00091733405,
0.013556988,
-0.014611051,
-0.016003212,
0.022035906,
0.003513547,
0.0066028163,
-0.0043057525,
0.00052081706,
0.0025224616,
-0.026689699,
-0.01294046,
0.02946076,
0.0015951835,
-0.02626542,
-0.012416743,
-0.002374959,
-0.031131351,
-0.0035168617,
-0.027087457,
0.0030743536,
-0.025005847,
-0.008876678,
-0.004146648,
-0.002161163,
0.026822284,
0.02259277,
0.005505662,
-0.023746274,
-0.04346191,
-0.007504406,
0.009665568,
0.03860924,
0.021333197,
-0.03354443,
0.023242444,
-0.021770732,
0.015287244,
-0.004746603,
-0.005167566,
0.02666318,
-0.024634605,
-0.012927201,
-0.0078822775,
0.013000124,
-0.004806267,
-0.0005813097,
0.03802586,
0.012827761,
-0.024846744,
-0.02536383,
0.014345879,
-0.0071994564,
-0.0039776005,
0.02816141,
0.040942766,
0.0003985887,
0.0063939923,
0.035771884,
0.0063840486,
0.002986515,
-0.0007288124,
-0.038953967,
0.012701804,
0.004647163,
0.033730052,
0.0047996375,
-0.01901293,
0.00875735,
-0.0074977768,
0.0012662028,
-0.0075574405,
0.028983448,
0.007126534,
0.015592193,
0.00796183,
-0.010699745,
0.003225171,
-0.0007661024,
-0.0062978673,
-0.009075558,
-0.02337503,
0.017262785,
-0.040836696,
-0.01442543,
-0.016785473,
0.014067447,
-0.0043521575,
-0.0076767686,
-0.015605452,
0.010799184,
-0.023626946,
0.016560076,
-0.02519147,
0.0021810508,
-0.009685457,
-0.0060757846,
-0.019649345,
0.004491374,
-0.017342336,
-0.03890093,
-0.021359714,
-0.011561559,
-0.033332292,
-0.03635527,
-0.00995063,
0.043780122,
0.0035698963,
0.024714157,
0.005054867,
-0.0018545561,
0.040041175,
-0.023971671,
-0.023534136,
0.008220374,
-0.03343836,
-0.008478918,
0.0022539736,
0.015393313,
-0.0074513713,
-0.017209752,
0.028320514,
-0.00826015,
-0.008803755,
0.013881825,
0.014597793,
-0.00557527,
0.02349436,
0.01333159,
0.03394219,
0.017435148,
-0.026557112,
0.009446801,
-0.02698139,
-0.01881405,
-0.033385325,
-0.021545336,
-0.011070987,
-0.006092358,
0.0010681514,
-0.013026641,
-0.0091087045,
0.00068199274,
-0.023905378,
-0.007232603,
0.022765132,
0.0092479205,
0.021730956,
0.009029153,
0.029407725,
0.024104258,
-0.017130198,
0.0017832908,
-0.015075105,
0.0132984435,
-0.00845903,
-0.0155126415,
0.019888002,
0.0052703205,
-0.016865026,
-0.009904224,
-0.0016415888,
-0.008419254,
0.034180846,
0.004110187,
0.0013300101,
-0.011044471,
0.014491724,
0.013278556,
0.023255704,
0.003095899,
-0.018071564,
-0.0027163695,
0.007013835,
0.00796183,
-0.031900354,
0.00093556475,
-0.033862635,
-0.013126081,
0.03542716,
0.00036005568,
0.00029749135,
-0.004060467,
0.019609569,
-0.015194433,
-0.024024706,
-0.028002307,
-0.021280162,
0.010911884,
-0.017859425,
0.042852014,
0.032112494,
0.03423388,
-0.002220827,
0.0040836697,
0.011276497,
-0.0048858193,
0.0050482377,
-0.018787533,
0.012005724,
-0.037840236,
0.017037388,
0.0043521575,
-0.009526352,
0.0038947337,
-0.047359962,
0.013881825,
0.029593347,
-0.0028705015,
-0.017872684,
0.01502207,
-0.042427737,
-0.023441324,
0.0029384522,
-0.014637569,
-0.0003327097,
-0.027657581,
0.013556988,
0.016241867,
0.0016987668,
0.009029153,
0.006059211,
0.03335881,
-0.004328955,
0.0066326484,
-0.012330561,
0.015247468,
-0.027418924,
-0.02597373,
-0.001285262,
-0.000492228,
0.0067221443,
0.011223462,
0.018151116,
-0.003987544,
-0.018151116,
-0.0017037388,
-0.0011054414,
-0.01890686,
-0.0085916165,
-0.025841143,
-0.015830848,
-0.011124022,
0.008127564,
-0.01662637,
-0.02179725,
0.017156716,
0.0069409125,
-0.024197068,
0.01800527,
0.006496747,
-0.011276497,
0.014292844,
0.015976695,
0.009228033,
-0.022420406,
0.030388866,
-0.004372046,
0.0051708804,
-0.033570945,
-0.01502207,
-0.009506465,
0.0061354483,
0.03484378,
0.016082764,
-0.011475377,
0.01671918,
-0.0014319362,
-0.00612219,
-0.02178399,
-0.028665239,
-0.010553899,
-0.017673803,
-0.0051775095,
0.007371819,
-0.024250103,
-0.013789014,
0.0042825495,
-0.0069276537,
0.036779545,
0.01303327,
-0.009095446,
-0.016838508,
0.016957836,
-0.010381537,
0.023746274,
-0.0033826176,
-0.01831022,
-0.011800215,
-0.007086758,
-0.017567735,
0.00915511,
-0.0025771535,
0.026875319,
0.0006919367,
0.008339702,
0.0383971,
0.0071861977,
-0.011017953,
-0.032908015,
-0.013556988,
0.042056493,
-0.023998188,
0.0019954294,
-0.019172033,
0.0017302561,
0.016387714,
0.01930462,
-0.011786955,
-0.00835959,
-0.045901507,
-0.0013084648,
0.023958413,
-0.002623559,
0.011687515,
-0.008425883,
-0.007815985,
-0.012171457,
-0.026875319,
-0.023467842,
0.031370007,
-0.05322029,
0.004146648,
0.0024926295,
0.023441324,
0.012721691,
0.0041532777,
-0.0051775095,
-0.0039345096,
0.026185868,
-0.031104835,
0.006049267,
0.0074381125,
-0.0060658404,
-0.04645837,
0.0042228857,
-0.01154167,
-0.019874742,
0.012549329,
-0.016096022,
-0.0067188297,
-0.0051808245,
0.0068613607,
0.016811991,
0.025947213,
-0.010739521,
-0.015764555,
-0.0011510181,
0.017130198,
-0.010500865,
-0.0063442723,
0.0031522482,
-0.024647864,
0.018774273,
0.023136375,
-0.011316272,
0.006947542,
-0.010487606,
-0.004070411,
0.009519723,
-0.0093937665,
0.0059431978,
-0.0031191015,
0.0064105657,
0.002419707,
0.020988472,
-0.019967554,
-0.015353537,
-0.018694721,
0.012105163,
0.018084822,
-0.008134193,
-0.012078647,
0.0095793875,
-0.01442543,
0.016891543,
-0.019225068,
0.00417648,
-0.0028025508,
-0.008372849,
-0.05504999,
-0.0027760335,
-0.0037787203,
0.035055917,
0.03065404,
-0.026040023,
-0.012197974,
-0.006281294,
-0.029725933,
-0.019490242,
0.018045047,
0.004498003,
0.011899654,
0.027631063,
-0.014876225,
0.020723298,
0.005267006,
0.025549453,
0.017289303,
-0.01742189,
0.018681463,
0.00457424,
0.02985852,
0.016294902,
-0.018800791,
-0.008843531,
0.018641686,
0.008883308,
-0.006261406,
0.013669686,
0.0028307256,
0.038688794,
-0.015459606,
-0.005204027,
0.0037986082,
0.01841629,
0.030972248,
-0.014916001,
-0.0010698087,
0.0110511,
0.0041731657,
-0.015539158,
0.026928354,
-0.01630816,
-0.005343243,
0.03126394,
-0.026159352,
-0.0221022,
0.011316272,
-0.020922178,
0.009864449,
0.01722301,
-0.003622931,
0.0214923,
-0.012423372,
0.009937371,
0.0039742854,
-0.014014412,
-0.008372849,
0.00507807,
0.006616075,
0.0017783188,
-0.014624311,
-0.008120934,
0.008618134,
-0.011269867,
0.0016001555,
-0.0062249443,
-0.012867537,
-0.031608663,
0.023799308,
-0.008578358,
0.0021628202,
-0.011137281,
0.01872124,
-0.02318941,
-0.021943094,
0.001096326,
0.007743062,
-0.031714734,
0.01213831,
-0.021147575,
-0.018562134,
-0.030362349,
0.013119452,
-0.0061553363,
-0.004057152,
0.0001629366,
0.19919822,
-0.018681463,
-0.008863419,
0.0030262908,
-0.0018363255,
-0.009685457,
0.010679857,
0.003483715,
0.0014319362,
0.018628428,
0.01910574,
-0.0017567734,
-0.0073320433,
-0.006596187,
0.024846744,
-0.016904801,
-0.0043753604,
0.004010747,
-0.019675862,
-0.013450919,
-0.000015149064,
0.0024230215,
0.016440747,
-0.01820415,
0.024037965,
0.002787635,
-0.026000248,
0.025032364,
0.015393313,
-0.0012164827,
-0.031078316,
0.010719633,
0.0032815202,
0.0018877028,
-0.008863419,
0.0077563208,
-0.004368731,
-0.0038450137,
0.006161966,
-0.011515153,
0.0067519764,
-0.0018711295,
0.010620193,
-0.008200486,
-0.006357531,
0.011667628,
0.0018843882,
-0.024528535,
0.0044714855,
-0.018562134,
-0.028691757,
0.030388866,
-0.0020849255,
0.022526477,
-0.016971095,
0.00006189105,
0.024395948,
0.012575846,
-0.0042361445,
0.016904801,
0.0048294696,
0.004438339,
-0.016573334,
0.02100173,
0.0017832908,
0.035161987,
-0.019052705,
-0.005644878,
0.032854978,
-0.01841629,
0.02428988,
-0.01941069,
0.0008659567,
0.0014012754,
0.0021313308,
-0.026742732,
0.050303385,
0.022460183,
0.027140493,
0.011329532,
0.008929713,
0.008445771,
-0.021717697,
-0.0016714208,
0.0013101221,
-0.026742732,
0.027498476,
0.0010159455,
-0.009745121,
-0.021319937,
0.009685457,
-0.015883883,
0.0070469817,
0.003682595,
0.010679857,
0.003279863,
-0.0021097856,
0.023812568,
-0.034392983,
-0.029991107,
-0.01990126,
0.05504999,
0.000530761,
0.012224492,
-0.0010648367,
0.01811134,
-0.0104279425,
0.003533435,
-0.01653356,
-0.0060757846,
0.021426007,
-0.014597793,
-0.0010134594,
-0.01074615,
0.008346331,
0.032695875,
0.02031228,
-0.038370583,
0.021770732,
-0.004693568,
-0.0015264042,
-0.01901293,
0.021571852,
0.023507617,
-0.0013590135,
-0.0046968833,
-0.018588653,
-0.0055686403,
-0.014160257,
-0.014080705,
-0.01253607,
0.0034969735,
0.00914848,
0.010832331,
-0.0017219695,
-0.0013416114,
0.007643622,
-0.011468748,
-0.042427737,
-0.0024992588,
0.0009438514,
-0.010295356,
0.015592193,
0.037946306,
0.015194433,
-0.014345879,
0.022049164,
0.00452452,
-0.03662044,
-0.0011178714,
-0.01829696,
-0.016944578,
-0.008127564,
0.0076966565,
0.010719633,
-0.020749815,
-0.009214774,
-0.036381785,
0.018031789,
0.0076767686,
0.0029898295,
0.0011965948,
0.02418381,
0.013616651,
-0.013669686,
-0.021611629,
-0.16652887,
-0.0018528989,
0.010388166,
-0.027790168,
0.016281644,
0.025788108,
0.011296385,
0.004952112,
-0.007643622,
0.000589182,
0.02805534,
0.009632422,
-0.03272239,
-0.032589804,
-0.01852236,
0.005939883,
-0.022712098,
0.05038294,
0.01563197,
-0.0031721361,
0.0027710616,
-0.008134193,
0.027140493,
0.008830273,
-0.000068986505,
0.005840443,
0.003692539,
-0.008207115,
-0.0114621185,
-0.022844685,
-0.023679981,
0.0044515976,
0.010122993,
-0.005293523,
0.008419254,
-0.0027959216,
-0.00826015,
0.004338899,
0.0028506136,
-0.0019042762,
0.03802586,
0.026809026,
0.020948695,
-0.0016946235,
-0.019158775,
0.0310518,
0.0016813648,
-0.023388289,
0.012522812,
0.0060890433,
0.011607964,
-0.025430124,
0.017687062,
0.021147575,
0.030998765,
-0.00090821873,
0.0066028163,
0.0048294696,
0.0054459977,
-0.0015661801,
-0.00835959,
-0.011548299,
0.03693865,
-0.016400972,
-0.015114881,
-0.03296105,
-0.018867085,
0.008293296,
-0.032059457,
-0.0049421685,
-0.006688998,
-0.006261406,
0.016135799,
0.0005473344,
0.004302438,
0.0047200858,
-0.01671918,
0.006609446,
0.0032218562,
-0.0038682164,
-0.012430001,
0.0264643,
-0.030627523,
-0.0045410935,
-0.013987894,
0.0010507494,
0.0054161656,
0.016599853,
-0.0020053736,
-0.010527383,
0.01930462,
-0.0036527629,
0.023308737,
0.0002637232,
0.026941612,
0.021969613,
-0.018893601,
-0.016639628,
-0.01881405,
-0.0043190112,
-0.0034041628,
-0.013842049,
-0.017647287,
0.009221403,
0.037681133,
-0.010288727,
0.00033623152,
0.007146422,
0.039219137,
-0.0038383843,
-0.01711694,
0.009121964,
-0.01890686,
0.027790168,
0.006685683,
0.025085399,
0.002350099,
0.005933254,
0.0087308325,
-0.021532075,
0.06714189,
-0.007922054,
0.0071199047,
0.027657581,
0.0025075455,
-0.0010905254,
-0.12654072,
0.0035798403,
0.008817014,
0.0026185869,
-0.020020587,
0.029089516,
-0.010169398,
0.03524154,
-0.024236845,
0.03672651,
-0.026411265,
-0.023772791,
-0.0128741665,
-0.015035329,
0.01263551,
0.0021561908,
0.007027094,
-0.00825352,
0.004322326,
0.03452557,
0.008445771,
0.0010988121,
0.016944578,
-0.034870297,
0.011999094,
-0.0039278804,
-0.03662044,
0.034870297,
0.013238779,
0.0044118217,
0.017673803,
-0.022261303,
0.020855885,
0.004372046,
-0.016652886,
-0.020418348,
-0.020484641,
-0.024448983,
0.03232463,
-0.00065257505,
-0.0010565501,
0.011011324,
-0.020391831,
-0.0076900274,
0.0034505683,
-0.013775756,
-0.00021358885,
0.015207692,
0.012469777,
0.0073983367,
-0.018853825,
-0.022619287,
-0.022049164,
-0.012754838,
0.0046736803,
-0.0146640865,
-0.0071663097,
0.0060558966,
-0.02138623,
-0.021638146,
0.003924566,
-0.0075773285,
0.0120720165,
0.013338219,
0.0143326195,
-0.008538582,
-0.02458157,
-0.036037058,
0.024024706,
-0.02389212,
-0.022712098,
0.009983777,
-0.01473038,
0.0022887776,
-0.03669999,
0.016798733,
-0.035692334,
-0.021240385,
0.027498476,
-0.022049164,
-0.01393486,
-0.023017047,
0.018628428,
-0.021823768,
0.039537348,
-0.0063674753,
0.0082137445,
-0.012058758,
-0.0044317096,
-0.012980236,
-0.0063409577,
0.029938072,
-0.0029997735,
-0.01294046,
-0.025708556,
0.005336614,
0.006188483,
-0.008127564,
0.015393313,
0.046909165,
-0.01872124,
0.0011916228,
-0.047651652,
0.016241867,
-0.0019738842,
0.009857819,
0.0069143954,
-0.012801244,
0.0074778884,
0.004398563,
-0.00085518404,
0.015618711,
-0.0141469985,
0.026490819,
-0.019065965,
-0.012224492,
-0.01581759,
-0.035771884,
0.020471383,
0.0048128963,
-0.009864449,
0.016268386,
0.022009388,
-0.008797126,
0.023825826,
0.022128716,
-0.004130075,
-0.012966977,
-0.02358717,
0.03664696,
-0.0052305446,
-0.01114391,
0.01164111,
-0.03412781,
-0.024846744,
-0.0017186548,
0.017925719,
-0.011800215,
-0.009970518,
0.0031456188,
0.011316272,
0.016865026,
-0.008313185,
-0.017541217,
0.025443383,
0.007491147,
-0.0036560777,
0.035639297,
-0.025708556,
0.008120934,
0.0008108504,
0.0026136148,
0.040598042,
0.010229062,
0.012317303,
-0.03126394,
-0.012158198,
0.0013772441,
0.0046040723,
-0.008797126,
-0.0047532325,
-0.010275467,
0.017899202,
0.0165203,
0.0062282593,
-0.0047731204,
-0.00049057073,
-0.003160535,
-0.015287244,
0.0025423495,
0.0010350047,
-0.035294574,
-0.017063905,
0.023123117,
0.008419254,
0.0059962324,
-0.00885679,
-0.0019655975,
-0.013278556,
0.0101428805,
0.0052404883,
0.009884337,
0.012715062,
0.021333197,
-0.013576875,
-0.0080281235,
0.038158447,
0.0019390802,
-0.027551511,
0.020365313,
-0.023202669,
-0.0008767294,
0.0069342833,
0.004289179,
0.014253068,
0.02169118,
-0.0086844275,
0.035639297,
-0.008976118,
0.0022340855,
-0.013828791,
0.032165527,
-0.01872124,
0.0023799308,
0.01492926,
-0.013669686,
-0.007013835,
0.036249198,
0.00032877352,
-0.0304419,
0.006317755,
0.0038847895,
0.0006815784,
0.030282797,
0.0006753634,
0.0049720006,
0.0015976694,
-0.0040936135,
-0.0016258442,
-0.023467842,
-0.018840566,
0.02747196,
0.020855885,
0.0007685884,
-0.004560982,
0.011873137,
0.018986411,
-0.006476859,
0.038688794,
-0.028240962,
0.018946636,
-0.022115458,
0.03773417,
-0.004259347,
-0.031979907,
0.0003097142,
0.0042361445,
-0.019384172,
0.036461335,
0.012834391,
-0.017329078,
0.07424854,
0.008744092,
-0.017435148,
-0.0056283046,
-0.046776578,
0.028214445,
0.01691806,
-0.0018661575,
-0.004716771,
-0.03383612,
0.034764227,
-0.017992012,
0.020908918,
-0.017872684,
-0.007895537,
0.018787533,
-0.014319361,
-0.009698715,
0.0030246335,
-0.013053158,
0.02169118,
-0.033730052,
0.016997611,
0.031502593,
-0.027737133,
-0.0046736803,
0.0056349337,
0.002454511,
0.00054692006,
-0.014717122,
0.010984806,
-0.019185292,
-0.042348184,
-0.013364737,
0.011806844,
-0.0062249443,
0.016692663,
-0.011289756,
0.037071235,
0.008067899,
0.016294902,
0.0028456415,
-0.0057774642,
-0.014253068,
0.01959631,
-0.0021644775,
0.006181854,
-0.007650251,
-0.008710945
] |
Hypoglycemia is among the most injurious metabolic disorders caused by endotoxemia. In experimental endotoxemia with lipopolysaccharide (LPS) in animals, a marked glucose consumption is observed in macrophage-rich organs. However, the direct effect of LPS on the uptake of glucose by macrophages has not been fully understood, and the present study was undertaken to shed light on this point. The consumption and uptake of glucose, as measured with 2-deoxy-D-[3H]glucose, by murine peritoneal exudate macrophages in culture were accelerated | [
-0.032336675,
-0.015444186,
0.0050361473,
-0.03549661,
-0.026451295,
-0.0035615107,
-0.016721327,
-0.0026184674,
-0.011026858,
-0.0065404084,
0.01930194,
0.013495559,
-0.0098287165,
0.010335622,
-0.0088346535,
0.005977545,
0.04718837,
-0.0059972946,
-0.00998013,
0.0052468097,
-0.0041079163,
0.020091925,
0.0053291,
-0.00032669125,
0.008169751,
-0.001940398,
-0.0031500608,
-0.038182557,
-0.011941924,
-0.012764824,
0.0062178317,
-0.023225527,
-0.025397982,
0.020842409,
0.010098628,
-0.026661957,
0.017774638,
-0.0009191792,
0.013851051,
-0.023462523,
0.0149701955,
0.036549922,
0.012172336,
0.01343631,
-0.0044535343,
-0.0030578962,
0.004466701,
-0.019288775,
-0.0063494956,
0.014680535,
0.024647499,
0.00072867784,
-0.002557573,
-0.011217771,
0.0014828657,
-0.0060302103,
0.008781988,
-0.0010409683,
0.013166399,
-0.036207594,
-0.009657553,
0.0013586078,
-0.026938451,
-0.0023798265,
-0.0009200021,
0.010375122,
-0.006267206,
0.025832474,
0.0013816489,
-0.004818902,
0.01747181,
0.040657837,
-0.0026201133,
0.006780695,
0.013482392,
-0.019802263,
-0.025384815,
0.0016351021,
0.0092823105,
0.0107503645,
0.021974718,
-0.014469872,
-0.027386108,
0.04313312,
0.010118377,
-0.022712037,
0.0027336734,
0.017708806,
-0.0075114304,
-0.026490794,
0.016405333,
0.020710744,
0.03944653,
0.023778515,
-0.012073588,
0.0072217695,
-0.007103272,
0.04942666,
0.0089070685,
-0.03304766,
-0.019064944,
0.0051184376,
-0.015773345,
-0.014641035,
-0.017247982,
-0.0113560185,
-0.0023008282,
0.0076825935,
0.021224234,
-0.0069979406,
-0.01129677,
0.053613573,
-0.0015997174,
-0.024792328,
0.0045062,
0.0099735465,
0.016497497,
-0.009216479,
-0.0053718905,
-0.017958967,
0.013943216,
0.017498143,
0.010493619,
-0.0060565434,
-0.0109807765,
0.0028422964,
-0.010315874,
-0.0010121668,
-0.026135301,
-0.005674718,
-0.0013725971,
0.022356546,
0.009571971,
-0.016879322,
-0.008610825,
0.032336675,
-0.041184496,
-0.008716156,
-0.010138127,
-0.022382878,
0.0098353,
0.021184735,
0.0006953504,
0.00868324,
0.015970841,
0.04452876,
0.037919227,
0.025147822,
-0.012567327,
0.011645679,
0.0080578355,
-0.025832474,
-0.00051760406,
-0.012001173,
0.025187321,
-0.004226414,
0.0037787564,
0.039235868,
-0.027228111,
-0.014285542,
0.0025131362,
-0.016905656,
-0.0029196488,
0.012442247,
0.008742489,
0.023159696,
0.0115995975,
0.017945802,
0.008307997,
-0.01835396,
-0.009657553,
0.020855576,
-0.0008870861,
0.026767287,
0.010770114,
0.029203072,
-0.0019914177,
0.02094774,
-0.012982069,
-0.02562181,
-0.0115995975,
0.024476334,
0.0022991823,
0.00055257726,
-0.014469872,
-0.0058853803,
0.0123500815,
-0.02936107,
0.008564742,
-0.0043185786,
-0.013409977,
0.027280778,
-0.0106779495,
-0.027070114,
-0.64589083,
-0.021039905,
0.015154525,
0.008992651,
-0.0099735465,
0.013021568,
0.0052599763,
-0.009097981,
-0.010954443,
0.025305819,
-0.009861632,
0.015417852,
0.0063527874,
-0.032836996,
0.020184088,
-0.017735139,
-0.014575203,
-0.0009850112,
0.003099041,
-0.016405333,
-0.012198668,
-0.0065206587,
-0.01740598,
-0.0016392166,
0.015115025,
0.01666866,
0.04186915,
-0.018788451,
-0.0005299475,
0.024686998,
-0.0055463454,
0.015970841,
0.0076825935,
-0.0053126416,
0.050716966,
-0.0121328365,
-0.011494266,
0.017392812,
0.015365187,
0.01864362,
-0.023423024,
-0.010875445,
0.015233523,
0.007491681,
0.0042790794,
0.026793621,
0.010019629,
0.01275824,
0.0051250206,
0.014101213,
0.016800325,
0.006846527,
-0.013205898,
-0.004127666,
0.032889664,
0.0071559376,
0.0068794433,
-0.020644912,
0.0067477794,
-0.00046411555,
0.002259683,
0.016681828,
-0.010467287,
-0.022672538,
-0.02730711,
0.014772699,
-0.023041198,
0.007439015,
0.005286309,
-0.004414035,
0.03726091,
0.026280131,
0.010026213,
0.018340793,
0.026609292,
0.018156463,
-0.00016869447,
0.020276254,
-0.02006559,
0.013627223,
-0.008393579,
0.008301415,
-0.023778515,
-0.0047728196,
0.017261147,
0.010934694,
-0.022619873,
0.0143513745,
-0.008577908,
-0.019947093,
0.010585784,
0.015470518,
-0.03341632,
-0.028097095,
-0.031652022,
0.026530294,
-0.016866157,
0.0040881666,
0.025964137,
0.00539164,
-0.035075285,
-0.0035746773,
0.0103619555,
0.00981555,
0.054087564,
0.020302586,
-0.027833767,
-0.007992004,
0.033284657,
-0.031046368,
0.0043679527,
0.0021922053,
0.0082882475,
-0.0145093715,
0.016221004,
-0.012929403,
0.012317166,
-0.001438429,
-0.005753716,
-0.037524235,
-0.004990065,
-0.010335622,
0.015088692,
0.007702343,
-0.009460057,
0.0016803616,
0.028860746,
-0.038366884,
-0.0017906302,
-0.020829242,
0.0031056243,
0.0026777163,
0.02975606,
-0.015852343,
0.025095155,
0.0048880256,
0.04558207,
0.008768821,
0.010256625,
-0.021237401,
-0.008235582,
0.0061157923,
0.0033080576,
-0.00637912,
-0.0015651556,
-0.0071822703,
-0.0058755055,
-0.01078328,
0.016207837,
0.012600243,
0.0003238111,
-0.0063494956,
-0.0017544226,
0.025950972,
0.000018373812,
-0.0004242049,
-0.01356139,
0.0012014338,
0.00506248,
0.01769564,
0.0021642267,
0.005845881,
-0.0047135707,
0.027517773,
-0.025674477,
-0.027254445,
0.021342732,
0.007169104,
-0.010513369,
-0.02376535,
-0.016576495,
-0.034996286,
0.00016530002,
0.004572032,
-0.000046545276,
0.026859453,
-0.0070901057,
0.00074925035,
-0.0009883028,
0.0025345318,
0.039314866,
0.0082158325,
-0.012712157,
0.026754122,
0.008900485,
0.005210602,
0.0062375814,
0.003329453,
-0.0041079163,
0.02226438,
-0.015088692,
0.027517773,
-0.020987239,
-0.015009695,
0.015654847,
-0.008268498,
-0.0046016565,
-0.006546992,
0.0017149234,
0.023317691,
0.021342732,
-0.026082635,
-0.0020539581,
-0.037497904,
0.029519066,
-0.018274961,
-0.0012549224,
-0.024502667,
0.012804323,
0.003798506,
0.008071003,
0.0132848965,
0.025569146,
-0.011448183,
0.009683887,
0.021000406,
0.007537763,
-0.019288775,
-0.017050486,
-0.018195963,
0.012073588,
-0.007597012,
0.032152344,
-0.016576495,
-0.018222295,
0.008604242,
0.018235462,
0.019104443,
-0.025187321,
-0.004749778,
-0.00662599,
0.0022201838,
0.01736648,
0.013304646,
0.009940631,
-0.0024752829,
-0.009473224,
-0.008261915,
0.023436189,
0.03249467,
0.0015174274,
0.0059512123,
0.037050247,
0.004430493,
-0.014838531,
0.00884782,
0.008386996,
0.005342266,
-0.025819307,
-0.00048592238,
0.007978838,
0.003485804,
-0.0059512123,
-0.0102895405,
-0.024976658,
-0.0019766055,
-0.0027254445,
0.008656907,
0.035733607,
0.0072744354,
-0.007932755,
-0.01915711,
0.0033179324,
-0.03812989,
0.01345606,
-0.017577142,
0.006230998,
-0.011856342,
0.0018893782,
0.0071230214,
-0.049558323,
0.014904363,
0.012646326,
-0.024647499,
0.011415267,
0.0042626215,
0.030756706,
-0.009394226,
0.034206305,
0.0003962263,
-0.001701757,
-0.016089339,
0.009104565,
0.018893782,
-0.0014746366,
-0.00401246,
-0.0262143,
-0.0047826944,
0.0072810184,
0.0091374805,
0.021408563,
0.008874153,
0.02051325,
-0.0004760476,
-0.012534412,
-0.009940631,
0.010862279,
-0.022343379,
0.030651376,
0.008143418,
0.0095258895,
0.022040552,
-0.021184735,
0.008913652,
0.034232635,
0.019683765,
-0.0040289178,
-0.007076939,
0.013811552,
-0.015286189,
-0.003940045,
0.0103619555,
-0.008689823,
-0.0005974253,
0.010809613,
0.025529647,
-0.038946208,
0.01615517,
0.023976011,
0.0041638734,
-0.009097981,
-0.034706626,
0.010585784,
-0.018222295,
0.0196706,
0.021342732,
0.0047629448,
0.0015931342,
0.007491681,
0.009262562,
0.015404686,
-0.025753476,
0.020539582,
0.0075575127,
-0.009045316,
0.012929403,
0.005148062,
-0.011329686,
0.019894429,
0.013383644,
-0.0018729202,
-0.028650083,
0.0019107736,
0.005148062,
0.031283364,
-0.01674766,
0.013120316,
0.018854283,
0.0026250507,
-0.0048616924,
-0.0062342896,
0.00096937607,
-0.019881262,
0.0012796094,
-0.020236755,
0.01901228,
-0.000060586004,
0.007998587,
-0.017748306,
-0.009354726,
0.0076825935,
0.0075838454,
0.018590955,
0.0138905505,
0.00007298093,
0.011711512,
0.011224355,
0.015088692,
0.011862925,
-0.0018268378,
-0.014417206,
0.030835705,
-0.012771406,
-0.009466641,
0.06735929,
-0.020934574,
-0.0063429126,
-0.017669307,
0.001899253,
-0.023488855,
0.020526415,
-0.004134249,
-0.017208483,
0.00981555,
-0.0012870155,
-0.023962846,
0.007399516,
-0.015259855,
-0.022106383,
0.008117084,
-0.0023419731,
-0.0040322095,
-0.022317046,
0.00475307,
0.01539152,
-0.028676417,
0.0012837239,
0.0028011512,
0.020987239,
0.010829363,
0.0023584312,
-0.0077418424,
0.019315107,
0.014114379,
-0.021329565,
0.0068136114,
0.0050789383,
-0.02720178,
0.030546045,
-0.005263268,
0.021685058,
-0.022764703,
-0.022343379,
-0.02862375,
-0.0053126416,
-0.0059808367,
-0.009729968,
0.023344025,
-0.0067477794,
-0.023120197,
-0.011540349,
0.0056187604,
-0.0064087445,
-0.008716156,
-0.007952505,
-0.020644912,
-0.04924233,
-0.008623991,
-0.0002750543,
-0.019617934,
-0.005401515,
-0.016142005,
-0.0031961433,
0.021922054,
0.012310582,
-0.00080438465,
0.004516075,
0.0125080785,
0.023962846,
0.02028942,
0.008176333,
0.014614702,
0.007590429,
-0.0017066944,
-0.022830535,
-0.012073588,
0.01897278,
-0.008953151,
-0.01604984,
0.0075114304,
-0.00786034,
-0.02687262,
-0.032547336,
-0.019617934,
-0.014088047,
0.009196729,
0.01784047,
0.008689823,
-0.025911473,
0.016260503,
-0.014114379,
-0.002580614,
-0.011270437,
-0.012389581,
-0.027465107,
-0.011013692,
-0.0102171255,
-0.029018743,
0.04152682,
-0.030388048,
-0.013693054,
0.0071493546,
-0.01520719,
0.014101213,
-0.017247982,
-0.012343499,
-0.047846694,
0.010645033,
-0.010394871,
-0.030730374,
-0.014483038,
-0.0033607231,
0.05253393,
0.025964137,
0.022843702,
-0.018959614,
0.022843702,
0.011527182,
0.0032948912,
0.019723265,
-0.00046329264,
-0.018261794,
-0.003403514,
0.009591721,
-0.0077813417,
-0.0034726376,
-0.0027386108,
-0.0053389748,
0.01816963,
0.020328918,
-0.01718215,
-0.011803676,
-0.001825192,
-0.015733846,
-0.013442893,
0.014838531,
-0.01985493,
0.009776051,
-0.03797189,
-0.05224427,
-0.002261329,
-0.0033426194,
0.009953797,
-0.017379645,
0.02471333,
-0.042343136,
0.008814904,
0.0052402266,
-0.0114811,
0.0070440234,
-0.020855576,
0.018880615,
0.00184165,
0.0025987178,
-0.005253393,
-0.0058755055,
-0.004934108,
-0.0026266966,
-0.0027731727,
-0.0077418424,
0.009018983,
-0.012093337,
-0.017577142,
-0.017155817,
-0.017669307,
0.008801738,
-0.011487682,
-0.03644459,
-0.01915711,
0.0063988697,
-0.026095802,
0.008531827,
-0.02917674,
-0.0097563015,
0.014206544,
0.00376559,
-0.0033179324,
-0.012534412,
0.026609292,
0.007471931,
-0.01323223,
-0.026885785,
0.0023979302,
0.008729322,
-0.013449476,
0.014272376,
-0.003943336,
-0.01722165,
-0.011665429,
-0.0039992933,
0.023686351,
-0.0011709866,
-0.0068860264,
0.017945802,
0.008117084,
-0.01897278,
-0.022396043,
-0.025345316,
-0.025898306,
0.0072546857,
-0.0066621974,
0.007432432,
-0.000571504,
-0.004874859,
-0.005398223,
0.034206305,
0.0076496773,
0.01125727,
-0.019591602,
0.0050690635,
0.0049604406,
-0.04747803,
-0.031862684,
0.023962846,
-0.017537642,
0.0143513745,
0.009091398,
0.019433605,
-0.0037425489,
-0.0041967896,
0.025239985,
0.006741196,
-0.015957676,
0.036207594,
0.010789864,
0.013864217,
0.02419984,
-0.0037227992,
0.018590955,
-0.015812844,
-0.002985481,
-0.015799679,
-0.0037359656,
-0.0039005456,
0.002383118,
0.017234815,
-0.015668014,
0.001216246,
-0.01901228,
0.0034100972,
-0.027833767,
-0.0360496,
0.013982715,
-0.011092691,
0.017932635,
-0.010269791,
-0.0048781508,
0.0018630454,
0.0033771812,
0.0051513533,
-0.015707513,
0.019736432,
-0.027386108,
0.03641826,
-0.002086874,
0.015352021,
-0.00258226,
0.002909774,
-0.023304526,
-0.01695832,
0.018301293,
0.01615517,
-0.04508175,
-0.014706867,
0.0014392519,
0.007886672,
0.015510017,
-0.0027764642,
0.047925692,
-0.028097095,
0.016694993,
-0.0045029083,
0.014799032,
0.042474803,
-0.014772699,
0.011830009,
0.024107676,
-0.01127702,
-0.0044370764,
0.0028241924,
-0.005167811,
-0.0020210422,
0.007761592,
-0.019868094,
-0.009776051,
0.022185382,
-0.020223588,
0.0030052306,
-0.021882555,
-0.016655494,
-0.014219711,
0.0064745764,
0.014522538,
-0.0007056367,
-0.029045075,
-0.0023781806,
-0.023172861,
0.0012993589,
0.0012754948,
0.0048551094,
0.0033327446,
-0.0005241872,
-0.0064120363,
-0.010743781,
-0.013469226,
0.025871973,
-0.024923991,
-0.020750243,
-0.01882795,
0.022277547,
-0.02485816,
0.0057833404,
-0.011922174,
0.000423382,
0.01440404,
-0.00030385578,
-0.02720178,
-0.0025328859,
-0.0011989651,
0.032415673,
-0.032468338,
-0.017037319,
0.010078878,
-0.016418498,
0.039104205,
-0.009914298,
-0.008867569,
-0.018261794,
0.02701745,
-0.000041890748,
-0.0033195782,
0.013324395,
0.0008525243,
0.005368599,
-0.02467383,
0.004809027,
0.0180248,
0.004111208,
-0.001693528,
-0.0061059175,
0.01012496,
0.023028031,
-0.01718215,
-0.003633926,
-0.02362052,
0.029334735,
-0.014219711,
0.0073271007,
0.0016128838,
-0.021408563,
0.008117084,
-0.003782048,
0.0053291,
0.0062375814,
0.0026546752,
-0.0013989299,
0.0088346535,
-0.021632392,
-0.00078381214,
0.00035240687,
-0.0128964875,
-0.004562157,
0.000021485403,
0.016102506,
-0.025200486,
0.011500849,
0.024265673,
-0.02215905,
0.015036027,
-0.006280372,
0.0012894842,
-0.015615349,
0.013146649,
0.011323103,
-0.019762764,
-0.014575203,
0.007662844,
0.0042659133,
0.014759533,
-0.0011742782,
0.005921588,
-0.0004258507,
-0.0114811,
0.0054936795,
0.014469872,
-0.0008459411,
-0.01747181,
-0.0014392519,
-0.023317691,
-0.0017297356,
0.17263782,
-0.03096737,
0.020197256,
0.02580614,
-0.015378353,
0.0064021614,
-0.03265267,
0.00112655,
-0.006958442,
0.017774638,
0.030888371,
-0.0055924277,
-0.0031418318,
-0.0058886716,
0.006833361,
0.015088692,
-0.02880808,
-0.014061714,
-0.0011940277,
-0.032836996,
0.000945512,
-0.0043054125,
0.029018743,
-0.006685239,
0.035338614,
0.003996002,
-0.0037919227,
0.019025445,
0.04207981,
0.021290066,
-0.0080578355,
0.014522538,
0.004891317,
0.005342266,
0.013640389,
0.017774638,
0.0120472545,
-0.02541115,
0.0058425893,
0.009223063,
0.005510138,
-0.018156463,
-0.0046411552,
0.0052007274,
-0.003656967,
0.004009168,
-0.008143418,
-0.010645033,
-0.014693701,
0.016405333,
-0.050348308,
-0.018248629,
-0.010888612,
0.010032795,
0.018116964,
-0.0044403677,
0.009038732,
0.019986592,
-0.003940045,
0.01740598,
-0.01849879,
0.007142771,
-0.013449476,
0.025924638,
-0.019367773,
0.02051325,
0.0040256265,
0.0009825425,
-0.02387068,
-0.014706867,
0.0035944267,
0.0070242737,
-0.016023507,
-0.0034397217,
0.00035693284,
-0.0006398047,
0.030256383,
0.02028942,
0.0067609455,
0.011349436,
-0.010487037,
-0.02094774,
-0.030651376,
-0.009381059,
-0.006570033,
-0.02230388,
0.01656333,
0.0025608644,
-0.042764463,
0.021448063,
0.018933281,
0.009288894,
-0.008031503,
-0.0041375407,
-0.0013775345,
-0.038077224,
0.024292005,
-0.010269791,
-0.0023139946,
-0.022488208,
-0.03446963,
0.072520524,
0.0027995054,
0.004364661,
-0.021500729,
-0.004226414,
-0.017458644,
0.015970841,
0.002261329,
0.0016556747,
0.004983482,
-0.017392812,
0.005730675,
-0.021487562,
-0.010210542,
0.038393218,
0.0378139,
-0.015115025,
0.011961673,
-0.013811552,
-0.018511957,
-0.005148062,
0.015286189,
0.006155291,
0.0011068004,
0.0068136114,
-0.02537165,
-0.0046576136,
-0.010250041,
-0.037155576,
-0.004743195,
-0.015602183,
-0.0061750407,
0.00932181,
-0.012488329,
0.010947861,
-0.011119024,
-0.001077176,
0.00047234455,
0.029018743,
-0.024252506,
-0.008558159,
0.020394752,
-0.014272376,
0.011099274,
-0.010138127,
0.015549516,
0.0030299174,
-0.013995881,
-0.008110502,
-0.022066884,
-0.009466641,
-0.0050690635,
0.0012680887,
0.014851698,
-0.021922054,
-0.010862279,
-0.032231342,
0.010974193,
0.007603595,
-0.028360423,
0.016444832,
0.02251454,
-0.01882795,
0.014153878,
0.00360101,
-0.16463265,
0.011968256,
-0.0002536589,
-0.00769576,
0.003016751,
0.0042527467,
-0.013640389,
0.0065831994,
-0.0196311,
0.0023995761,
0.056878842,
0.0016951738,
-0.0426328,
0.0019552102,
-0.00016077407,
-0.02146123,
0.0052402266,
0.0180643,
0.004545699,
0.00058590475,
0.014575203,
-0.025950972,
-0.0008977838,
-0.010243458,
0.008867569,
0.034153637,
0.008637157,
0.040052183,
-0.0012071942,
-0.010882028,
-0.031204365,
0.002894962,
0.021000406,
0.0006484451,
0.011856342,
-0.0055693868,
0.010487037,
0.0064087445,
-0.007076939,
0.0106582,
0.036260262,
0.013245397,
-0.0130874,
0.0026497378,
-0.005928171,
0.011632513,
0.014562037,
0.0095258895,
0.023962846,
0.004539116,
0.015997173,
-0.0111387735,
-0.0045062,
0.04171115,
-0.00662599,
0.014272376,
0.011217771,
0.017313814,
-0.008999233,
0.0037458404,
0.0012047255,
-0.041632153,
0.017590309,
0.0043350365,
0.009934047,
-0.035338614,
0.0032981827,
-0.0076891766,
-0.014272376,
-0.0026365712,
-0.030862039,
-0.0057668826,
0.0043613696,
-0.01160618,
0.024976658,
0.027280778,
-0.0035121369,
0.010190792,
-0.0016211128,
-0.0003203138,
-0.0018284835,
-0.01045412,
-0.028544752,
-0.024765996,
-0.029861392,
-0.0015404687,
0.026332797,
0.0054146815,
-0.0004291423,
-0.012995236,
0.008531827,
-0.025753476,
-0.00006120318,
-0.019328274,
0.0033524942,
0.024410503,
0.0067938617,
-0.005674718,
-0.010072295,
0.00999988,
0.003831422,
-0.015180858,
-0.016221004,
0.01487803,
0.011079525,
-0.016892489,
-0.027833767,
-0.005753716,
0.05761616,
-0.02481866,
-0.028123427,
-0.021803556,
-0.000020752506,
0.019644266,
0.015312522,
0.02928207,
0.016760826,
-0.013903717,
0.014338208,
-0.021513894,
0.062672056,
-0.008307997,
-0.027254445,
0.026569793,
0.0006056543,
-0.016497497,
-0.13987982,
-0.034311634,
-0.0040355013,
0.0057767574,
0.002901545,
0.023488855,
0.005167811,
0.006602949,
0.0066490313,
0.012093337,
0.006346204,
0.003864338,
-0.007261269,
-0.022093216,
0.027096448,
0.019512603,
0.027228111,
0.003650384,
-0.01860412,
0.028413087,
-0.002927878,
-0.023423024,
-0.0034890955,
0.007899839,
0.011882675,
-0.017247982,
-0.011421851,
0.019499436,
0.0035615107,
0.01860412,
0.027702102,
0.006593074,
0.01722165,
-0.0008607533,
0.0049933568,
-0.0023979302,
0.0075114304,
-0.027438775,
0.03041438,
-0.023304526,
-0.0018712744,
0.031151699,
0.025977304,
0.0129689025,
0.0019173567,
-0.010013046,
-0.025582312,
-0.0026102385,
0.009953797,
-0.019907594,
-0.03181002,
-0.025384815,
-0.03523328,
-0.0078076744,
0.03739257,
-0.0022185382,
0.009170396,
0.038735546,
-0.017300647,
0.0015297709,
0.019104443,
0.01047387,
-0.015338854,
-0.00563851,
0.019328274,
-0.02526632,
-0.014759533,
-0.04376511,
0.020671245,
-0.011435017,
0.009104565,
0.0041309576,
0.0116720125,
-0.014983362,
-0.03389031,
0.0022580374,
-0.0037260908,
-0.021645559,
-0.004581907,
-0.010585784,
0.009400808,
-0.013278313,
0.01619467,
-0.0108227795,
-0.0009998233,
0.018406626,
0.018340793,
0.010789864,
0.005806382,
0.00151249,
-0.0056845928,
0.01864362,
0.021829888,
-0.02028942,
-0.004769528,
0.019222941,
-0.016484331,
-0.0066325734,
0.02244871,
-0.0050855214,
0.0114811,
0.0010779989,
-0.041395158,
0.019473104,
0.00027073408,
0.0068662767,
0.008044669,
-0.017063653,
-0.017498143,
-0.020895075,
0.013666722,
0.009940631,
-0.034074638,
0.0042724963,
-0.022501376,
0.0043383283,
-0.027359776,
-0.03446963,
0.024489501,
0.009479807,
0.011362602,
0.024068177,
-0.0014112734,
-0.00020521066,
-0.025792975,
0.030256383,
-0.0032521004,
0.0078274235,
-0.017274315,
0.02160606,
-0.008327747,
-0.044686757,
0.009288894,
-0.035733607,
-0.0046905293,
-0.014285542,
-0.013047901,
-0.019736432,
-0.005279726,
0.03320566,
0.00985505,
0.03802456,
-0.026885785,
-0.022093216,
-0.018143296,
-0.01681349,
0.0070571895,
-0.0055924277,
-0.017669307,
0.015246689,
-0.0058886716,
-0.008558159,
0.042343136,
0.027517773,
-0.022093216,
-0.021790389,
-0.012962319,
0.0143513745,
0.0009298769,
-0.0013874093,
-0.027517773,
-0.022290712,
0.016931988,
-0.0059479205,
0.008051253,
-0.011336269,
0.023699516,
-0.029703395,
-0.01290307,
0.007011107,
-0.01292282,
-0.038709212,
-0.026135301,
0.005230352,
0.01047387,
0.0036207596,
0.013811552,
-0.0011866216,
-0.017050486,
0.01999976,
-0.0007451359,
0.012198668,
-0.0018844408,
-0.012251333,
-0.04321212,
0.013614056,
0.044186432,
-0.013693054,
0.01030929,
0.031309694,
-0.0031615815,
0.006691822,
-0.0071822703,
0.0070901057,
-0.0009183563,
-0.0081895,
0.017234815,
0.017932635,
0.00062869553,
0.000041787887,
0.0145093715,
0.00041247858,
0.016036673,
-0.004677363,
-0.009571971,
-0.034285303,
-0.016971488,
0.019683765,
-0.030467046,
-0.04892634,
0.0012812552,
0.016379,
0.005292892,
0.0013347437,
0.006082876,
0.00516452,
-0.029887725,
0.010045962,
-0.01356139,
0.013166399,
-0.007939339,
0.023291359,
0.0278601,
0.01553635,
-0.0074060992,
0.0008912006,
0.011402101,
0.0034627628,
0.03360065,
-0.025871973,
0.03341632,
0.007234936,
0.022132715,
-0.006257331,
-0.049031667,
-0.019933928,
0.010770114,
-0.019802263,
0.005671426,
0.02014459,
-0.009861632,
0.06362004,
-0.0013832947,
0.007432432,
-0.0065074926,
-0.010032795,
0.023449356,
0.004792569,
0.022435542,
0.0056780092,
-0.014311875,
0.02306753,
-0.015312522,
0.023278192,
-0.07557513,
-0.034627628,
0.007656261,
0.003393639,
0.0049768984,
-0.015826011,
-0.011230938,
0.027596772,
-0.010197376,
-0.016615994,
0.010559452,
-0.018143296,
0.017735139,
0.03784023,
0.006497618,
0.02061858,
-0.026411796,
0.004812319,
0.017195316,
-0.03528595,
-0.020236755,
0.003115499,
-0.0021477689,
-0.023923347,
-0.020855576,
0.00720202,
-0.018090632,
-0.019525768,
0.004117791,
-0.03030905,
-0.026056303,
-0.022185382,
-0.010039379,
-0.03370598,
-0.0074060992,
-0.014680535
] |
CONTEXT Certification by an American Board of Medical Specialties (ABMS) member board is emerging as a measure of physician quality. OBJECTIVE To identify demographic and educational factors associated with ABMS member board certification of US medical school graduates. DESIGN, SETTING, AND PARTICIPANTS Retrospective study of a national cohort of 1997-2000 US medical school graduates, grouped by specialty choice at graduation and followed up through March 2, 2009. In separate multivariable logistic regression models for each specialty category, factors associated with ABMS member board certification were identified. MAIN OUTCOME MEASURE ABMS member board certification. | [
-0.0022976683,
0.0033431156,
0.002367144,
-0.05843918,
-0.028822584,
0.018487213,
-0.0018957003,
-0.0024845914,
0.006434794,
-0.0062892255,
-0.013094558,
-0.019029787,
-0.0077019027,
0.015443506,
-0.0139745865,
-0.012604918,
0.04412052,
0.013855485,
0.012836505,
0.0049923416,
-0.030860545,
0.004128855,
-0.019625295,
0.012472583,
0.0071659456,
0.014239256,
0.001981718,
-0.034592394,
-0.0034539462,
-0.0065605124,
0.0069542094,
0.012869588,
-0.0156155415,
-0.006940976,
-0.033348445,
0.0029394934,
-0.013908419,
-0.015390572,
0.024574628,
0.008304028,
-0.00033580032,
0.0013299678,
-0.0043075075,
-0.014371592,
0.006616755,
-0.021742657,
0.013478329,
-0.02397912,
-0.028002108,
0.033586647,
0.025593609,
0.00450601,
-0.023171876,
-0.017706437,
0.007668819,
-0.0077085197,
-0.0050188084,
0.0118506085,
-0.00003703832,
-0.023515947,
-0.012505667,
-0.0013986166,
-0.0068351077,
0.00799304,
-0.010666209,
-0.009647229,
-0.024601094,
0.006090723,
0.016833024,
-0.0024697038,
0.0048103807,
-0.0054091974,
0.0049063237,
0.0045953365,
0.037874304,
-0.009878815,
-0.029722463,
-0.004826923,
-0.015575841,
-0.0075497176,
-0.0134915635,
-0.03303084,
-0.0019122422,
0.017018294,
0.009164206,
0.00597493,
-0.0059583876,
0.0030635574,
-0.00948181,
-0.0017997574,
0.009858965,
0.023383612,
0.003741775,
0.0040262956,
-0.0016616326,
0.034936465,
0.0026003846,
0.025765644,
0.014503927,
-0.018301943,
0.0027823455,
0.020763377,
-0.033427846,
-0.018646015,
-0.024005586,
-0.024879,
-0.01726973,
-0.020869246,
0.026096482,
-0.021583855,
-0.006669689,
0.046687823,
-0.0081716925,
-0.017997574,
-0.011222016,
-0.0014680926,
-0.006127115,
0.01824901,
0.010017767,
-0.0072784303,
0.02145152,
0.011083065,
0.02522307,
-0.015364105,
0.01425249,
0.010811778,
-0.042664837,
-0.013855485,
-0.007099778,
-0.003295144,
-0.00040300173,
-0.012102045,
-0.008674566,
0.021425053,
-0.002367144,
0.021927927,
-0.013094558,
0.010699293,
-0.032819103,
-0.035174668,
0.018275477,
0.011665339,
-0.0249584,
0.020048767,
-0.016806558,
0.025024567,
0.05089608,
0.026943427,
0.0078077707,
-0.0081716925,
-0.012849738,
-0.03811251,
-0.018341646,
0.029431326,
0.00035192867,
0.0099118985,
0.02661259,
0.027684502,
0.0074769333,
-0.022219064,
-0.0118506085,
-0.010229503,
0.0020445774,
-0.02405852,
0.0026003846,
0.016184583,
-0.0016161425,
-0.0225102,
-0.010143485,
-0.0046317284,
-0.028690249,
0.030410606,
-0.028002108,
0.0053562634,
-0.008601782,
0.0027145238,
-0.005716876,
0.020723676,
-0.020459006,
-0.024865765,
-0.011791057,
-0.02055164,
0.02593768,
0.001498695,
-0.013240127,
0.0375567,
0.029060788,
0.01617135,
0.004601953,
-0.0034407126,
-0.011327884,
0.0034010122,
0.01447746,
0.0022612761,
-0.6335146,
-0.013121025,
0.0055779247,
-0.01572141,
0.02805504,
0.0025127127,
0.009753097,
0.00041230654,
-0.0024217323,
0.0146494955,
-0.026017081,
0.014384826,
0.022047028,
0.0014308733,
-0.0012042494,
-0.011400669,
0.013412163,
-0.0031148375,
0.023582114,
-0.014490694,
-0.011453602,
0.020948647,
0.0008055899,
0.0066399137,
-0.015377339,
0.016369851,
-0.0027112153,
-0.005028734,
0.004089155,
0.014040754,
-0.02850498,
0.029272525,
0.015192069,
0.03205156,
0.04824938,
0.003013932,
-0.022682237,
0.00043008907,
-0.00854223,
0.016991828,
-0.002418424,
-0.030675275,
0.0151391355,
0.0047541386,
-0.021874992,
0.043114774,
-0.0010909375,
0.013577581,
0.009547978,
-0.004952641,
0.016197816,
0.014583328,
-0.00058847765,
0.0008395008,
0.011327884,
-0.012373332,
0.016343385,
-0.019559128,
-0.0051676854,
-0.022563135,
-0.0049824165,
0.00723873,
-0.00010054366,
-0.006398402,
-0.02077661,
0.032633837,
-0.0057896604,
0.018090209,
0.023687983,
-0.018831285,
-0.012545368,
0.021253018,
-0.013511414,
0.024032054,
0.029246056,
0.015734643,
0.01971793,
0.00091807474,
-0.010692676,
-0.006467878,
0.0174947,
-0.011413902,
0.014636262,
-0.00231421,
-0.0026897108,
-0.0055613825,
-0.023820318,
0.010871328,
-0.0075166337,
-0.0053165625,
0.013246743,
0.0023522563,
-0.0029659604,
-0.012869588,
0.013881952,
0.008820134,
-0.026625821,
0.005918687,
0.02450846,
-0.014345124,
-0.038853586,
0.016594822,
0.02047224,
0.024495227,
-0.01602578,
0.0059716213,
-0.012737254,
-0.010031001,
0.03959466,
-0.031681024,
0.011188933,
-0.009885432,
-0.019294458,
0.009435493,
0.0077680703,
-0.029325457,
0.0125189,
-0.008839984,
-0.015919913,
-0.0007170908,
0.0011231941,
-0.0030089694,
0.006451336,
-0.031125216,
-0.01398782,
0.01280342,
0.0019056255,
0.028107975,
-0.007589418,
-0.0077349865,
-0.02375415,
-0.023171876,
-0.0037318498,
-0.010242737,
0.019069487,
0.0051147514,
-0.004965875,
-0.0072519635,
-0.018288711,
-0.015880212,
-0.009362708,
-0.024680495,
0.002568955,
-0.012485817,
-0.024177622,
-0.014583328,
-0.007172562,
0.019585595,
-0.005531607,
0.022113195,
0.018646015,
-0.011023514,
0.002130595,
0.024071755,
-0.011493304,
-0.02522307,
-0.014887699,
-0.009640612,
-0.010070701,
0.007291664,
-0.020908946,
0.011327884,
-0.0022943597,
-0.009018637,
0.013630515,
-0.04287657,
-0.0199826,
-0.0010801853,
-0.020114936,
-0.017600568,
0.017507933,
0.00093378953,
0.020498706,
-0.001638474,
-0.008687799,
0.005531607,
-0.017018294,
-0.0014441068,
-0.014014287,
-0.0075100167,
0.0020296895,
0.0021851833,
-0.0016922351,
0.004681354,
0.024601094,
-0.0077879205,
0.011757974,
-0.0015822315,
-0.004678046,
0.013087941,
-0.0013250052,
0.047905307,
0.0028683632,
0.020419305,
0.0033877785,
0.008615015,
-0.015575841,
-0.020234037,
0.017600568,
0.013948119,
0.012472583,
0.009289924,
0.04422639,
-0.007662202,
0.010315521,
-0.0039899033,
0.0088466015,
-0.011559471,
-0.00032091263,
0.017587334,
0.00723873,
-0.005567999,
0.0018394579,
-0.008211393,
-0.015483207,
-0.0027806913,
-0.0077349865,
0.004433226,
-0.010573574,
0.010963963,
-0.008720883,
0.004433226,
0.03390425,
0.0037583169,
0.015192069,
0.01470243,
-0.00944211,
0.0011885347,
0.007913639,
0.009263457,
0.024587862,
0.011506537,
0.03411599,
0.011294801,
0.0107786935,
0.0060543306,
0.0014970409,
-0.029563662,
0.027075762,
0.0017732903,
-0.012896055,
0.03019887,
0.023436546,
0.00621975,
0.0059021455,
-0.019837031,
0.014080455,
0.007073311,
0.014755364,
0.0047905305,
-0.03909179,
-0.016952125,
-0.00048178248,
0.008350344,
0.03019887,
0.008701033,
-0.0066729975,
0.014331891,
0.024402592,
0.0057962774,
0.039568193,
0.02224553,
-0.0053661885,
0.0058161276,
0.028134443,
-0.00026177536,
0.0021868376,
-0.03252797,
0.010811778,
-0.022086728,
-0.031654555,
-0.014887699,
-0.010474323,
-0.003655757,
-0.002795579,
-0.016131649,
-0.0073247477,
0.014596562,
0.00089243485,
0.016316919,
-0.01425249,
-0.029695997,
0.005716876,
0.019625295,
-0.013001923,
0.008224626,
0.013544497,
-0.0060543306,
-0.013948119,
0.0109771965,
-0.0035962064,
-0.00072908367,
-0.020961879,
-0.023873253,
-0.0006281782,
0.021888226,
0.020353138,
-0.016197816,
-0.0057797353,
0.0020131478,
0.013564347,
-0.018672483,
-0.02296014,
-0.03607455,
0.025236303,
0.0106860595,
-0.022179363,
-0.0065572043,
-0.01151977,
0.0012431229,
0.017772604,
-0.027022827,
-0.03401012,
-0.008045974,
0.025143668,
0.02224553,
-0.0051246765,
-0.020167869,
0.029351925,
-0.012922523,
-0.01021627,
-0.008959087,
0.0033364987,
0.010573574,
0.07336658,
0.002200071,
-0.018328412,
0.025818577,
-0.015933147,
0.0010768769,
0.0037020743,
-0.025990613,
0.017587334,
0.028769651,
-0.0010735685,
0.023052774,
0.013326145,
0.004337283,
-0.0018957003,
0.011056597,
0.021954393,
0.0018626165,
-0.013246743,
-0.0061370404,
-0.025051035,
-0.0057367263,
0.049228657,
0.04814351,
0.037980173,
-0.015271471,
-0.010024384,
0.019267991,
0.012062345,
-0.031786893,
-0.03898592,
0.003804634,
-0.006249525,
0.034433592,
0.0010214616,
0.015840512,
0.015364105,
-0.003189276,
-0.020114936,
-0.00030747234,
0.050287336,
0.017097695,
0.009289924,
-0.018619549,
0.010606659,
-0.000049987517,
0.0099118985,
0.009852348,
0.028875519,
0.0025259461,
0.012247614,
-0.00064017106,
-0.015192069,
-0.023198344,
0.01474213,
-0.022099962,
-0.00033269872,
-0.0035134968,
0.0074372324,
-0.020710442,
-0.028610848,
-0.01957236,
0.016938893,
-0.021702956,
-0.038747717,
-0.022219064,
-0.06330911,
-0.008165075,
-0.031231083,
0.028557915,
0.019122422,
-0.0146494955,
-0.022364631,
0.01099043,
0.026030313,
-0.0060741813,
0.033374913,
-0.0094288755,
0.023343911,
0.035280537,
-0.017772604,
-0.0076489686,
0.005538224,
-0.009852348,
0.004006445,
0.025725944,
0.000455729,
-0.009554594,
-0.010044234,
0.017256496,
0.0066663804,
-0.015245004,
-0.013617282,
-0.011619022,
0.004171864,
-0.0036359068,
0.004135472,
0.010183186,
-0.024270257,
-0.02069721,
-0.0022381174,
-0.023635048,
0.0077614537,
-0.025699476,
0.0146494955,
-0.0023770693,
-0.02567301,
-0.007066694,
-0.01474213,
-0.014226023,
0.030225337,
-0.0249981,
0.013656982,
-0.007893789,
0.0047806054,
0.011400669,
0.017177096,
0.043458845,
0.007781304,
-0.0042314148,
0.034327723,
-0.011837374,
0.0150068,
0.004869932,
-0.035995148,
0.013934886,
-0.021358885,
0.0071130116,
-0.023066008,
-0.020789845,
-0.003708691,
0.026599355,
-0.0045126267,
-0.011049981,
-0.0105868075,
0.006411636,
0.0062991506,
0.027605101,
0.003592898,
-0.0004408413,
0.0032488266,
0.019770864,
0.006540662,
-0.016052248,
0.052087095,
-0.028187376,
-0.00597493,
0.004443151,
-0.025117202,
0.016422786,
-0.010057468,
0.021358885,
-0.012141746,
0.0033364987,
-0.0047905305,
-0.038535982,
-0.011016897,
-0.008390046,
0.057327565,
0.021160383,
0.00538273,
-0.018712183,
0.016488953,
0.010428006,
0.0035465807,
0.014861232,
-0.0022910514,
0.015059735,
-0.013617282,
0.008555464,
0.009673696,
-0.019704696,
-0.016131649,
-0.0019734472,
0.0048004556,
0.026136182,
0.015602308,
-0.02816091,
-0.015972847,
-0.016316919,
-0.0035465807,
-0.0073842984,
0.0067887907,
0.029246056,
-0.05171656,
-0.014993567,
0.004724363,
0.027843304,
-0.0149671,
-0.013961353,
0.011665339,
-0.022682237,
0.042664837,
-0.01451716,
0.0067954073,
-0.018566614,
-0.0014589945,
-0.008065824,
-0.00723873,
-0.0043273577,
0.0077548367,
0.017296197,
0.001358916,
-0.0127174035,
-0.006967443,
-0.0010677788,
-0.028187376,
-0.015628776,
0.008793667,
-0.007721753,
0.012102045,
-0.021319184,
-0.009878815,
0.00077085197,
0.00611719,
0.028690249,
-0.015747877,
0.014781831,
-0.012856355,
-0.0079731895,
0.026784625,
-0.02134565,
0.0041784807,
-0.0023869944,
0.010897796,
0.02797564,
-0.0009916861,
-0.014053987,
0.014331891,
0.026308218,
0.0012348519,
0.0500756,
0.021583855,
-0.006123807,
-0.0070600775,
0.018950386,
0.026361153,
-0.004304199,
-0.03279264,
0.035756946,
-0.0060609477,
-0.026480254,
0.018143142,
0.017177096,
-0.040785678,
0.02163679,
-0.020961879,
-0.008813517,
0.004932791,
-0.0299342,
0.0007476933,
0.015245004,
-0.029643063,
0.02650672,
0.010461089,
-0.019241523,
-0.0059650047,
-0.011817524,
-0.018354878,
0.015509673,
-0.014239256,
0.014636262,
-0.0058492115,
0.00074190367,
0.002795579,
0.024667263,
0.007847471,
0.015642008,
-0.024415826,
0.02974893,
-0.0053331046,
-0.03136342,
0.011764591,
-0.00660683,
-0.017481467,
0.012313781,
-0.013094558,
-0.021014813,
-0.010514024,
-0.008912769,
0.029854799,
0.019320924,
-0.013451863,
0.0223911,
-0.013193809,
-0.01771967,
0.0060245553,
-0.004453076,
-0.0073048975,
-0.028399112,
-0.015483207,
0.020803077,
-0.016647756,
0.0072850473,
0.0033414613,
0.010930879,
0.010414773,
-0.007926872,
-0.027763903,
0.013140875,
-0.011149232,
-0.005746652,
-0.03072821,
-0.019479727,
-0.015350872,
-0.043538246,
0.011400669,
0.0103022875,
-0.014120155,
-0.016144883,
0.00042347232,
-0.0027641493,
-0.0044464595,
-0.025514208,
0.006027864,
0.0023969195,
0.021107448,
-0.02473343,
-0.013372462,
0.0045357854,
0.0003868734,
0.0011446986,
-0.0010884561,
-0.00923699,
0.005567999,
-0.004284349,
0.0149406325,
-0.007265197,
-0.05010207,
-0.007020377,
-0.0059881634,
0.03393072,
-0.03271324,
-0.011360968,
-0.019135656,
-0.007046844,
-0.0063520847,
0.04131502,
-0.006414944,
-0.0070931613,
0.002181875,
-0.0146494955,
-0.00012406416,
0.027313964,
-0.021292718,
-0.019651763,
-0.024614329,
-0.014292191,
-0.013504797,
-0.005405889,
-0.009230373,
0.033110242,
0.015880212,
0.022047028,
-0.011380819,
0.02198086,
-0.061668158,
-0.0053033293,
-0.0032537892,
0.030569408,
-0.008839984,
0.012922523,
0.013392312,
-0.009640612,
0.013842251,
0.010692676,
-0.02073691,
-0.02216613,
0.029351925,
-0.015853744,
0.02805504,
0.009607528,
-0.02548774,
0.015311171,
0.006398402,
-0.009739864,
-0.0041321632,
0.022404332,
0.0059352294,
-0.013789318,
0.021888226,
-0.015536141,
-0.003847643,
0.010514024,
-0.00027604276,
-0.035280537,
0.0018692333,
-0.004899707,
0.01704476,
0.013345995,
-0.011294801,
0.0015235079,
0.01249905,
0.034248322,
-0.008204776,
-0.0058293613,
-0.010262587,
-0.008813517,
0.019188588,
0.01812991,
0.0044034505,
0.018593082,
-0.007933489,
0.00499565,
-0.0076158848,
0.005495215,
-0.0066663804,
-0.010732377,
-0.01076546,
-0.020538408,
-0.014503927,
-0.011757974,
-0.009210523,
-0.017547633,
0.0010404848,
-0.0141730895,
-0.006027864,
-0.018037274,
0.022576367,
0.0056474004,
-0.023661517,
-0.023105709,
0.0030916787,
-0.036392152,
-0.000049522274,
-0.020406073,
0.016727157,
-0.012942373,
-0.0011356006,
0.00070799276,
-0.0043968335,
0.020564875,
0.0199032,
0.017997574,
-0.00640171,
0.0038542598,
0.18653956,
-0.0044563846,
-0.0031677715,
0.025739176,
-0.0010834936,
0.010480939,
0.0045622527,
0.020392839,
-0.019810565,
0.012068961,
0.0054885983,
0.018976854,
-0.000028069515,
0.004294274,
0.025090735,
-0.033110242,
-0.007695286,
-0.012068961,
-0.02024727,
0.0099913,
0.019995833,
-0.013524647,
0.0010413118,
-0.0124792,
0.012532134,
0.024336426,
-0.0042744237,
0.023648283,
0.023171876,
0.014636262,
0.009647229,
-0.019784097,
-0.021147149,
-0.005792969,
-0.0030006983,
-0.012022643,
-0.021782357,
-0.028981388,
0.012571834,
0.02141182,
-0.019784097,
0.002777383,
-0.008442979,
-0.028849052,
0.019784097,
0.028716717,
-0.0029229515,
0.0035631226,
-0.021557387,
0.01474213,
-0.029987134,
0.0012141746,
0.012022643,
0.0013398929,
-0.008826751,
0.0016442636,
0.012214529,
-0.013372462,
0.01790494,
-0.0059650047,
0.017812304,
0.007953339,
-0.03125755,
0.03792724,
-0.003672299,
0.013465096,
-0.017216796,
-0.008330494,
-0.009495043,
-0.007814388,
-0.0058690617,
0.005574616,
-0.0024233866,
0.018090209,
-0.013167342,
-0.039938733,
0.031733956,
0.03223683,
0.010566957,
0.03295144,
-0.009839115,
-0.024826065,
-0.021425053,
0.007834238,
-0.028187376,
-0.021464754,
0.011559471,
0.026705222,
0.011658723,
-0.023555648,
0.0043339743,
0.0006050195,
-0.0035432724,
-0.0060179387,
0.0037517,
0.0061899745,
-0.006765632,
0.0024266948,
-0.028187376,
0.003215743,
-0.035545208,
0.104809396,
0.0027740744,
-0.0034374043,
0.0052173114,
-0.02047224,
-0.027419833,
0.0101037845,
0.026625821,
0.007933489,
0.01635662,
-0.05960373,
-0.0026400853,
-0.013524647,
0.0025226378,
0.030622343,
-0.005697026,
-0.023952654,
0.014874465,
-0.023992354,
0.009131121,
-0.015337638,
0.016528653,
0.024190856,
0.012393182,
-0.005654017,
0.007873938,
0.004611878,
-0.013815785,
-0.015377339,
-0.009170823,
-0.014239256,
-0.0038145592,
0.0103022875,
0.00854223,
0.009362708,
-0.0224705,
-0.02118685,
-0.0475877,
0.031522222,
-0.0016111798,
0.00079855963,
-0.003013932,
-0.0015218536,
0.01700506,
-0.023092475,
0.004969183,
0.01847398,
-0.010441239,
-0.011658723,
-0.013154109,
-0.0066002132,
0.0016409552,
-0.033295512,
0.019598829,
-0.01123525,
-0.016502187,
-0.035492275,
-0.012340248,
0.0033646198,
-0.01953266,
0.0043339743,
0.041712023,
-0.016700689,
-0.003348078,
-0.0010793582,
-0.16653049,
0.017441766,
0.031310484,
-0.02303954,
0.021425053,
-0.021941159,
0.015192069,
-0.008495914,
-0.023595348,
-0.021425053,
0.0399652,
0.011890309,
-0.040521007,
-0.010183186,
-0.005395964,
0.00646457,
-0.010904412,
0.022563135,
0.009263457,
0.022338165,
0.010480939,
-0.0124395,
0.005756577,
-0.007622502,
0.013319528,
-0.007920256,
0.0019916433,
0.038165443,
0.004006445,
-0.0013051549,
0.02130595,
-0.012776954,
0.014503927,
-0.0018510371,
-0.009058338,
0.016369851,
-0.009753097,
-0.024376126,
0.006229675,
0.007212263,
0.004314124,
0.0055812327,
-0.00059013185,
0.0031512296,
0.003137996,
0.017031528,
0.027419833,
-0.00640171,
0.0450204,
-0.028478513,
0.013240127,
-0.01025597,
-0.006934359,
-0.007556334,
0.018460747,
0.0062991506,
0.012446116,
-0.011870459,
-0.013802551,
0.013279827,
0.006292534,
-0.0151391355,
0.0069542094,
0.010083934,
-0.025950912,
-0.029378392,
-0.002287743,
0.016766857,
-0.03416892,
-0.01900332,
-0.011718273,
0.01794464,
0.018579848,
-0.018010806,
0.030701743,
0.0198635,
0.016502187,
0.033057306,
0.015946379,
0.003470488,
-0.0019932974,
0.010547107,
-0.011605788,
0.006914509,
-0.000033626555,
0.018076975,
-0.008290794,
0.007311514,
0.008707649,
-0.015774343,
0.026175883,
-0.037794903,
-0.0039138105,
0.0042876573,
0.010917646,
0.014186323,
-0.032633837,
-0.0024002278,
-0.0041487054,
-0.012128511,
0.023026308,
0.0015665167,
-0.026850792,
0.009488427,
-0.0043703667,
0.0036590656,
-0.0077879205,
0.00032484133,
0.035545208,
0.0011306381,
-0.004277732,
-0.0023075934,
0.011400669,
0.02560684,
0.020379605,
0.034142457,
0.013385695,
-0.015258237,
-0.0031942385,
-0.0132004265,
0.040415138,
-0.01196971,
-0.01967823,
0.019095955,
0.011016897,
-0.009064955,
-0.11359645,
-0.006940976,
0.01119555,
0.017362365,
0.006057639,
0.015165603,
-0.00450601,
0.017931405,
-0.02371445,
0.04396172,
-0.003496955,
-0.03231623,
0.0067490903,
-0.030331206,
0.011056597,
0.0055812327,
0.005802894,
-0.03448653,
-0.011162465,
0.033639584,
0.0031826592,
-0.017468233,
0.0040726126,
0.008350344,
0.018288711,
-0.021570621,
-0.010394922,
0.009144356,
0.0016161425,
0.020353138,
-0.010176569,
-0.005395964,
0.010831628,
-0.0032819104,
0.011777824,
0.0074901665,
-0.00028596786,
-0.016303685,
0.03943586,
0.0067490903,
0.004760755,
-0.01398782,
0.0044993935,
-0.034512993,
0.010983814,
-0.006765632,
-0.025408339,
-0.0028551298,
0.015866978,
-0.019519428,
-0.0054224306,
-0.0095281275,
-0.034407128,
-0.0071328618,
-0.0023886485,
0.00069641345,
0.009270074,
0.012247614,
-0.033507247,
0.0006881425,
-0.0033795077,
0.00801289,
-0.027922707,
0.009514893,
0.00821801,
-0.0019684846,
-0.016369851,
-0.016052248,
-0.0055349157,
-0.022774871,
-0.003303415,
0.023635048,
-0.02914019,
0.002813775,
-0.020035533,
0.021729423,
-0.03411599,
-0.006170124,
-0.010441239,
-0.02585828,
-0.012386565,
-0.00043091617,
0.022841038,
-0.010858095,
0.015284704,
0.0069542094,
-0.006057639,
0.00018506237,
0.008833368,
-0.020908946,
0.01103013,
0.049255125,
0.025315704,
-0.006275992,
0.0061370404,
0.016753623,
0.00854223,
-0.0071460954,
0.009495043,
-0.002128941,
-0.024879,
0.0039733616,
-0.06161522,
0.02216613,
-0.003612748,
-0.0044663097,
0.015469973,
-0.005783044,
0.016502187,
-0.020234037,
0.0035730477,
0.0076555857,
-0.002305939,
0.016039014,
-0.00012975044,
-0.01151977,
-0.024627563,
-0.035068803,
0.04803764,
0.02299984,
0.020048767,
0.008621632,
-0.019241523,
-0.015893446,
0.0069078924,
0.014953867,
-0.005706951,
0.012770337,
-0.0056043915,
0.0073313643,
-0.02824031,
-0.020604575,
0.008912769,
-0.017878473,
0.008734116,
0.017521167,
-0.023026308,
-0.0084562125,
0.01824901,
0.017018294,
0.008535614,
0.028557915,
-0.011354351,
-0.008026124,
0.022721937,
-0.03382485,
-0.0055845412,
-0.00095860235,
-0.03393072,
0.046317283,
0.0022927057,
-0.015840512,
0.005564691,
0.005395964,
-0.009124505,
-0.05179596,
-0.013749617,
0.010838245,
0.021239784,
0.014278958,
-0.011559471,
-0.036736224,
0.018500447,
-0.0016988518,
0.019929666,
0.0125189,
-0.007245347,
-0.01447746,
-0.0018295328,
0.014318658,
-0.005697026,
-0.0060179387,
-0.03268677,
0.0066729975,
-0.022457266,
0.011585938,
-0.0123336315,
-0.0068351077,
-0.005300021,
0.0060444055,
-0.01549644,
0.040970948,
-0.0067193145,
0.028531447,
-0.0068351077,
0.023211576,
0.01272402,
-0.015417039,
-0.016105182,
0.012161596,
0.003040399,
0.001069433,
-0.011857225,
0.018804818,
-0.009316391,
-0.008045974,
-0.0011008626,
0.014001054,
0.022669002,
-0.015694942,
0.024759898,
0.013630515,
-0.018659249,
-0.020075234,
0.017428532,
-0.02393942,
-0.021001581,
0.014080455,
-0.040044602,
-0.014980333,
-0.036868557,
0.020445773,
0.019651763,
0.01945326,
-0.002497825,
0.00401637,
-0.019956132,
0.020022301,
-0.02141182,
-0.0046945876,
-0.013081324,
0.03408952,
-0.0023158642,
0.004109005,
0.00972663,
-0.0006720142,
0.018844519,
0.011777824,
0.031151682,
-0.016568355,
0.0044563846,
0.0016045631,
-0.004625112,
-0.016502187,
-0.001349818,
-0.014120155,
0.009369325,
-0.038138974,
-0.008125375,
-0.00086017814,
0.009978066,
0.06039774,
0.016277216,
-0.0073247477,
0.002269547,
-0.0034638713,
0.028346179,
0.006940976,
0.014927399,
0.009488427,
-0.009468576,
0.037106764,
-0.018103441,
0.007053461,
-0.022007328,
-0.010712527,
0.016316919,
0.0030999498,
0.039277058,
0.025170136,
-0.033269044,
-0.0018973545,
-0.013154109,
0.0064182524,
0.014675963,
-0.017415298,
-0.0111756995,
-0.00748355,
-0.0040296037,
-0.007053461,
-0.031284016,
0.004671429,
0.010348605,
-0.061668158,
0.0052305446,
0.032448567,
-0.022033794,
-0.012379949,
-0.019598829,
0.019625295,
0.031416353,
0.0014523778,
-0.0030056608,
-0.018844519,
-0.022946905,
-0.020445773,
-0.026003847,
-0.025117202,
-0.013590815,
-0.020803077
] |
BACKGROUND Obesity is associated with diverse health risks, but the role of body weight as a risk factor for death remains controversial. METHODS We examined the association between body weight and the risk of death in a 12-year prospective cohort study of 1,213,829 Koreans between the ages of 30 and 95 years. We examined 82,372 deaths from any cause and 48,731 deaths from specific diseases (including 29,123 from cancer, 16,426 from atherosclerotic cardiovascular disease, and 3362 from respiratory disease) in relation to the body-mass index (BMI) (the weight in | [
0.005333918,
-0.020265704,
0.02263492,
-0.026061365,
-0.0040665157,
-0.0003208312,
-0.02720776,
0.015157881,
-0.009273057,
0.0058052135,
-0.008241301,
0.0026398913,
-0.0024981843,
0.017323293,
-0.025055086,
0.022074461,
0.048250467,
-0.0055122464,
0.0076999487,
-0.020749738,
-0.0282013,
0.003646171,
-0.020622361,
0.010381238,
-0.004865807,
0.0340097,
0.02308074,
-0.021870656,
0.012151781,
-0.03260855,
0.025322577,
-0.015425373,
-0.033933274,
-0.009897205,
-0.019437753,
0.01683926,
-0.007840063,
-0.016762832,
-0.00074754463,
-0.026443496,
-0.005060057,
0.012584862,
0.006216005,
0.013183535,
-0.00568739,
0.0017482514,
0.014189814,
-0.049142104,
0.0072604977,
0.0177309,
0.0034137077,
0.0355637,
-0.016992113,
-0.0073942435,
-0.0030267995,
-0.002383545,
-0.023972379,
0.01973072,
0.02324633,
-0.011565845,
0.008012023,
-0.017883752,
-0.020647837,
-0.013349125,
-0.01505598,
-0.01360388,
-0.013017945,
0.033525664,
0.014533733,
0.03632796,
0.025513643,
0.030468615,
-0.006260587,
0.02781917,
0.017985653,
-0.017934702,
-0.00886545,
0.012170887,
-0.007980178,
-0.0032704084,
0.020915328,
-0.013374601,
0.011024493,
0.01750162,
0.011578583,
-0.0153998975,
-0.01538716,
0.005617332,
0.02080069,
-0.0054549263,
-0.008113924,
0.0056109633,
0.0042862413,
0.012215469,
-0.0037385195,
0.002057141,
0.00024997766,
0.023781314,
-0.01064873,
-0.016928423,
-0.0106168855,
0.007056694,
-0.015922144,
-0.0026860656,
-0.027462514,
-0.00016101268,
-0.012030772,
-0.004540995,
0.0047989343,
-0.024036068,
0.002227508,
0.036761045,
-0.007368768,
-0.0107442625,
-0.01092259,
-0.013234486,
-0.0011806269,
0.013973273,
-0.005228832,
-0.021195559,
0.0073114485,
-0.0044422783,
0.038365997,
-0.0013860227,
-0.014635635,
-0.027895596,
-0.033474714,
-0.018851819,
0.0024488256,
-0.004662004,
0.009903573,
0.0017625813,
0.011113657,
-0.005101455,
-0.021322936,
0.033041634,
-0.0014433423,
-0.0050027375,
-0.014559208,
-0.024774855,
0.0056778365,
0.010731525,
-0.021450313,
-0.026023151,
-0.007852801,
0.03767816,
0.030570516,
0.01593488,
-0.007776375,
-0.0044741225,
-0.016049521,
-0.0012108791,
0.044250824,
-0.0049486025,
0.01248933,
-0.000048686932,
0.012565756,
0.031054549,
-0.019361326,
-0.018648015,
-0.003119148,
0.011814231,
0.0046428973,
0.013272699,
-0.0072222846,
0.005741525,
-0.005738341,
-0.017947441,
0.0051715123,
0.0062574027,
-0.009515073,
0.038722653,
-0.016202373,
0.02408702,
0.016584504,
0.000058414367,
-0.0062319273,
0.021590427,
-0.04091354,
-0.012565756,
-0.014520995,
0.03923216,
0.02927127,
0.026927529,
-0.013183535,
0.016966637,
0.015030504,
-0.012674026,
0.012750452,
-0.021373887,
0.021335673,
0.013514716,
-0.01026023,
0.004056962,
-0.66399163,
-0.019858098,
0.0037831014,
0.0072222846,
0.0053052586,
0.016100472,
0.017310554,
0.026163267,
-0.0072668665,
0.0244182,
-0.008960983,
0.0059580663,
0.008725335,
-0.0114384685,
-0.0050409506,
-0.0069102105,
-0.00549314,
-0.006693669,
-0.0074388254,
-0.007871908,
-0.015769292,
0.019819885,
-0.007954703,
0.030341238,
-0.020940803,
0.041474,
0.019870836,
-0.03133478,
0.005480402,
0.030086484,
0.0060567837,
0.028914614,
0.016457127,
0.03362757,
0.047740955,
-0.0325576,
-0.018966459,
0.02720776,
0.009190261,
0.021361148,
-0.021615902,
-0.025156988,
0.046136003,
-0.0028835002,
-0.0135019785,
0.0054772175,
0.017998392,
0.013463764,
0.020558672,
-0.028328678,
0.02034213,
0.017654473,
0.007827326,
-0.0177309,
-0.003728966,
-0.0122600505,
0.029678876,
-0.029857203,
-0.0072732354,
-0.0008781062,
-0.013973273,
0.00097045465,
-0.028354153,
-0.016253324,
-0.0401238,
0.031513106,
-0.005267045,
0.04264587,
-0.014712061,
-0.012215469,
0.008591589,
0.024672953,
-0.0073432927,
0.026214218,
0.037397932,
0.02268587,
0.035640128,
0.023399184,
-0.02029118,
-0.012349214,
0.0028707625,
0.012788666,
0.0021064996,
0.013183535,
-0.0010389199,
-0.0021335674,
-0.009667926,
-0.00199186,
-0.005012291,
-0.017030325,
0.018100293,
-0.0021351594,
-0.01510693,
-0.011495788,
0.007336924,
0.010858902,
-0.010820689,
-0.01934859,
0.020278443,
-0.0020189278,
-0.027717268,
-0.005072795,
-0.0025889406,
0.012215469,
0.008547007,
0.008438736,
-0.028914614,
-0.004021934,
0.036761045,
-0.019883573,
0.02257123,
0.004540995,
0.009566024,
-0.004330823,
0.013011576,
-0.018011129,
0.022316476,
-0.0065981364,
0.01003732,
-0.014839438,
0.021195559,
0.01164864,
0.010113746,
-0.017144965,
-0.0066745626,
0.034799438,
-0.013361863,
0.005681021,
-0.00869349,
-0.041907083,
0.009986369,
-0.0012514805,
0.0031350702,
0.010253861,
0.028914614,
-0.024571052,
-0.0041397572,
-0.010827058,
0.004611053,
-0.009610606,
-0.02190887,
-0.019157523,
0.015005029,
-0.008591589,
-0.0060313083,
-0.027589891,
0.0012156557,
-0.0011153462,
0.032379273,
-0.00094338704,
0.0037512572,
-0.034315404,
-0.010655099,
-0.01632975,
0.010706049,
-0.0014465267,
-0.011120025,
-0.0009075622,
0.0051651434,
0.0021845181,
0.013400076,
-0.012998838,
-0.02598494,
0.005926222,
-0.0010962397,
-0.038340524,
-0.019501442,
-0.0021877026,
-0.0071777026,
-0.017578047,
0.005072795,
-0.017068539,
0.017068539,
0.010858902,
-0.007171334,
0.0068337843,
-0.012311001,
-0.0064134398,
-0.007871908,
-0.017361505,
0.018546114,
-0.0002873947,
-0.033372812,
0.007776375,
0.04985542,
0.009406802,
0.004314901,
-0.00035466577,
-0.0048753605,
0.017323293,
-0.014138863,
0.024953185,
-0.021781493,
0.014368143,
0.02524615,
-0.0031064104,
-0.0135019785,
0.002865986,
0.021195559,
0.006770096,
0.014113388,
-0.023348233,
0.0144700445,
-0.019819885,
-0.00063569157,
0.008088449,
0.026188742,
-0.0040442245,
0.0043340074,
0.011221927,
0.012724977,
0.012718609,
-0.0013987604,
-0.007680842,
-0.0130816335,
-0.0067828335,
0.0018756286,
-0.022533018,
-0.00089960115,
-0.012005297,
0.010056426,
-0.017017588,
0.033780422,
-0.018482424,
0.0012307818,
0.015858455,
0.009508705,
0.023946904,
-0.0060567837,
-0.013438289,
-0.014699323,
0.0051205615,
0.0008860673,
0.0129542565,
-0.004716139,
-0.014903126,
-0.009897205,
-0.03372947,
0.013183535,
0.01883908,
-0.00429261,
-0.014189814,
0.0023628462,
-0.00769358,
0.0003200351,
-0.016686406,
0.02280051,
0.006098181,
-0.014648372,
-0.006878366,
-0.0008948245,
-0.008903663,
-0.00819672,
-0.0044836756,
0.0051141926,
-0.02336097,
0.0069484236,
-0.0026860656,
0.025857562,
0.021717804,
0.04180518,
0.0035697448,
-0.010508615,
0.005263861,
0.01956513,
0.0024934078,
-0.020138327,
-0.0005353821,
0.017399719,
-0.00892277,
-0.035767503,
-0.0057956604,
0.015603701,
-0.040607836,
0.006238296,
0.020112852,
0.028608909,
-0.007566203,
0.014126126,
0.011457575,
-0.001901104,
-0.0026351148,
0.00841963,
0.027589891,
-0.009674295,
-0.013947798,
-0.0048753605,
0.009139311,
0.002695619,
0.036022257,
0.010999017,
0.020202016,
-0.010094639,
-0.010565935,
-0.018800868,
0.005524984,
0.0063019847,
-0.029959107,
0.02385774,
-0.019717984,
0.006528079,
-0.00981441,
0.0066299806,
-0.0025762029,
0.026851103,
0.0162788,
0.0013852265,
0.0056842053,
0.00540716,
0.009744352,
-0.00869349,
-0.033780422,
-0.014622897,
0.01778185,
-0.0029455966,
0.02420166,
0.0014091097,
0.0009847846,
0.008266777,
-0.004553733,
0.00060504145,
-0.018240409,
-0.031793337,
-0.027513465,
0.06236385,
0.00063330325,
0.008311359,
0.005333918,
0.008668015,
0.0062351115,
0.0045696553,
-0.027666317,
0.017909227,
0.022150887,
0.0010675797,
-0.00069181714,
0.024316298,
-0.002464748,
0.00593896,
0.0031080025,
0.00880813,
-0.029576974,
-0.015489061,
-0.010686943,
-0.011979821,
0.0053721312,
0.035334423,
0.058899194,
0.021564951,
-0.005948513,
0.011565845,
0.04086259,
-0.008368678,
0.009585131,
-0.018431474,
0.018380523,
0.00092428044,
0.029143892,
-0.009279425,
0.014126126,
0.011750543,
-0.004620606,
-0.0034073389,
-0.0062191896,
0.017285079,
0.0059007467,
0.003662093,
0.003862712,
0.017769113,
-0.008890925,
-0.006846522,
0.057166867,
0.003585667,
-0.009546918,
0.03925764,
0.0086998595,
-0.014750274,
-0.050212074,
0.010776107,
-0.01883908,
-0.005267045,
-0.01393506,
-0.012075354,
-0.0012865092,
0.01588393,
-0.022418378,
0.023679413,
0.007770006,
-0.004566471,
-0.0010914629,
-0.04025118,
-0.014355405,
-0.021386623,
-0.005690574,
0.017208653,
-0.019042885,
0.014712061,
0.011916133,
0.0008741257,
0.021259246,
0.014737536,
-0.026239693,
0.0076681045,
-0.0068274154,
0.002748162,
0.032200944,
-0.016367964,
-0.028226776,
0.007018481,
0.010865271,
0.012126305,
-0.023335494,
-0.020622361,
0.0046428973,
-0.018405998,
0.008941876,
0.004760721,
0.0072350223,
0.0028994223,
-0.0073178173,
0.0091010975,
-0.0026494449,
-0.00085422304,
-0.0147247985,
0.014304454,
-0.011069074,
-0.020367606,
-0.019641556,
0.01967977,
-0.009050147,
0.0054453732,
-0.009279425,
0.024061544,
0.005496324,
0.013259961,
-0.025004135,
0.01226642,
-0.008375048,
0.013374601,
0.028761761,
0.025297102,
0.035894882,
0.011884288,
-0.0048753605,
-0.015234307,
-0.0016718251,
-0.009056515,
0.0136293555,
-0.012941519,
-0.0022784588,
-0.020252967,
-0.009712508,
-0.037474357,
-0.0081521375,
0.0065853987,
-0.001463245,
-0.004114282,
-0.01538716,
-0.02592125,
0.00292649,
0.0023787683,
0.0036047734,
-0.011616796,
-0.01750162,
-0.016508078,
0.004818041,
-0.0001908667,
-0.03958882,
0.03841695,
-0.03016291,
-0.008833606,
-0.008769917,
0.008183982,
0.014559208,
-0.005849796,
-0.0033691255,
-0.025500905,
-0.010400345,
0.0030650126,
-0.008438736,
-0.0091010975,
-0.0015380791,
0.061854344,
0.014584684,
0.020711524,
0.024672953,
0.057727326,
0.018979196,
0.011502157,
-0.01064873,
0.0030172463,
0.011247402,
-0.003305437,
0.017234128,
0.013552929,
0.017310554,
-0.029220318,
0.012323739,
-0.0010030951,
0.011680485,
-0.0010389199,
-0.015438111,
-0.021450313,
-0.023271805,
-0.0025443586,
-0.009948156,
0.001374081,
0.021488525,
-0.047205973,
-0.018686228,
0.015438111,
0.014126126,
-0.013718519,
-0.0006739047,
0.0026828812,
-0.03260855,
0.023284543,
-0.0077190553,
-0.020877115,
-0.0061905296,
-0.013374601,
0.010285705,
0.007158596,
-0.010298443,
-0.007941965,
0.015068717,
0.006009017,
-0.0031780598,
-0.007477039,
-0.0007758065,
-0.049244005,
-0.012833248,
0.0013287029,
-0.023653938,
-0.021042705,
-0.018367786,
-0.00014727983,
-0.018418737,
-0.01996,
0.013298174,
-0.021399362,
0.020354869,
-0.007241391,
-0.028328678,
-0.022864198,
-0.0010452888,
-0.0064038862,
-0.014775749,
0.047944758,
0.01192887,
-0.0125530185,
-0.0266473,
0.013451027,
0.014126126,
0.00752799,
0.013998749,
0.008260408,
-0.005480402,
-0.00079371885,
-0.007680842,
0.0081394,
-0.031538583,
-0.025679234,
0.018609801,
-0.027844645,
0.009916311,
0.016877472,
0.023182642,
-0.030137435,
0.010451295,
-0.011100919,
-0.013705782,
0.015310734,
-0.03762721,
0.019526917,
0.008324097,
-0.026672775,
-0.0013334795,
0.0100691635,
-0.022660395,
0.0036780152,
-0.019819885,
-0.026953004,
0.006623612,
0.020889852,
0.016036782,
-0.011903395,
0.008190351,
0.014686585,
0.018495163,
-0.002389914,
0.019883573,
-0.034213502,
0.029194843,
-0.00588164,
-0.014113388,
-0.009483229,
-0.0132090105,
0.007770006,
0.007884646,
-0.021004492,
-0.01834231,
-0.01204351,
-0.014062437,
0.016546292,
0.03082527,
-0.0033022526,
0.0043403762,
-0.038493376,
-0.025844824,
0.003824499,
-0.021666853,
-0.0007746123,
-0.015234307,
-0.013196273,
-0.016597243,
-0.017246867,
0.026672775,
0.009801672,
-0.014686585,
-0.00964245,
0.0008645724,
-0.020838901,
0.031054549,
0.011056337,
-0.001870852,
-0.0007312245,
0.036073208,
-0.02865986,
-0.021781493,
-0.004935865,
0.03372947,
-0.03663367,
-0.045295317,
-0.00696753,
0.024736643,
0.017348768,
0.000017054108,
0.016979374,
0.013387338,
-0.0062351115,
-0.01660998,
-0.036735572,
0.021271985,
-0.015540012,
0.021004492,
0.033805896,
-0.0035315314,
-0.003467843,
-0.015501799,
0.023552036,
-0.007763637,
-0.0036589087,
-0.016240587,
-0.03176786,
0.03472301,
0.0025188832,
0.012903306,
-0.012584862,
0.0029822176,
-0.025615545,
0.023208117,
-0.010897115,
-0.017934702,
0.004620606,
-0.021221034,
-0.016074996,
0.0027593076,
-0.007464301,
-0.029194843,
0.007999285,
0.0024185737,
-0.024494626,
-0.0072159157,
-0.01042582,
0.035359897,
0.02268587,
-0.011049968,
-0.031487633,
-0.0081712445,
-0.028226776,
0.009432278,
0.00048562538,
0.014533733,
-0.002389914,
0.019768935,
0.01571834,
0.019182999,
0.006295616,
0.007101276,
-0.04649266,
-0.025602808,
0.009769827,
-0.01315806,
0.009610606,
-0.007126752,
-0.009559656,
-0.0025602807,
0.022380166,
-0.007820957,
-0.012667658,
0.012572125,
0.007012112,
0.0047543524,
-0.019972738,
0.005738341,
0.00250933,
0.00493268,
0.0031589533,
-0.024774855,
0.0028978302,
0.003550638,
0.0020316655,
0.013884109,
-0.018877294,
0.0046906634,
0.010005475,
-0.000033660406,
-0.021386623,
-0.01660998,
0.0018230855,
-0.021361148,
0.024889495,
0.0076298914,
0.00892277,
0.019896312,
0.001975938,
0.007114014,
-0.0132090105,
-0.003986905,
-0.009884467,
-0.008464212,
-0.0070248498,
0.009718876,
-0.0092475815,
-0.018418737,
0.02413797,
-0.011183714,
0.010387607,
-0.010183803,
-0.033092584,
-0.011623165,
0.02720776,
0.0053785,
-0.021603165,
-0.008203088,
0.019463228,
-0.024672953,
-0.0006583806,
-0.022583969,
-0.010572303,
-0.0054326355,
-0.01248933,
0.0069038416,
0.007961072,
0.0023994672,
-0.005696943,
-0.0340097,
0.0039709825,
0.016902948,
0.17853181,
-0.017527096,
-0.0027147254,
0.02263492,
0.008406892,
0.020507721,
0.009585131,
-0.009336745,
-0.0064261775,
0.015603701,
-0.013170797,
-0.004611053,
-0.0026016783,
0.012635813,
0.01862254,
0.014419094,
-0.03658272,
-0.016266063,
0.0118588125,
-0.01209446,
-0.00880813,
-0.013037051,
-0.018100293,
0.0020364423,
0.023908691,
0.01855885,
-0.0063879644,
0.0010365315,
0.005467664,
-0.006222374,
-0.006566292,
-0.013667569,
0.0035538224,
0.02301705,
-0.019335851,
-0.0065089725,
-0.013591142,
-0.036098685,
0.022380166,
-0.01148305,
0.0033213592,
-0.015603701,
0.011387518,
-0.003763995,
0.0009831924,
0.019501442,
-0.0025013688,
-0.014673848,
-0.02263492,
-0.020928066,
-0.037831012,
-0.0074961456,
0.015960356,
0.013030683,
0.008725335,
0.012623075,
0.004760721,
-0.018482424,
-0.00032441368,
-0.008820868,
0.019526917,
0.008744441,
-0.023883216,
0.025742922,
-0.013552929,
0.01360388,
-0.01098628,
0.005174697,
-0.01131746,
-0.014164339,
-0.0031095948,
-0.015132406,
-0.028379628,
-0.008655277,
-0.010164697,
-0.020953542,
0.03138573,
-0.0022099935,
-0.0037225971,
0.0125530185,
-0.008738073,
-0.010011844,
-0.0010500654,
-0.00039646137,
-0.036710095,
-0.021539476,
-0.002748162,
0.023182642,
-0.013654831,
0.0024536024,
-0.0019488704,
0.003350019,
-0.0037767326,
0.0015667389,
0.011744173,
-0.006260587,
-0.0037735482,
-0.0014345852,
0.00021335673,
-0.016151423,
-0.017705424,
0.06776465,
-0.0023278175,
0.0005437412,
0.00791649,
-0.014559208,
-0.027768219,
0.00987173,
0.020138327,
-0.007655367,
0.0032640395,
-0.015565488,
0.004337192,
-0.015094193,
0.0027242787,
0.018405998,
0.011814231,
-0.011158238,
-0.0032290109,
-0.036251538,
-0.010190172,
-0.028328678,
0.031920712,
0.013107109,
0.016979374,
0.021514,
-0.007279604,
-0.011610427,
-0.014126126,
-0.017628998,
0.008375048,
-0.024991397,
-0.017208653,
-0.007852801,
0.0015046427,
-0.01639344,
-0.00043865506,
-0.00493268,
-0.011584952,
0.02603589,
-0.006407071,
-0.032990683,
-0.024099758,
-0.018125769,
0.020635098,
-0.02697848,
-0.00044303364,
0.007324186,
0.0026271536,
0.010094639,
-0.027997497,
0.009445015,
-0.023310019,
-0.0016137093,
0.025883038,
0.0057606315,
0.004604684,
-0.03997095,
-0.007566203,
0.011610427,
-0.008839974,
0.0030061007,
0.026774677,
-0.024634741,
0.0066045052,
0.0042766877,
-0.1593743,
0.033474714,
0.01599857,
-0.021883395,
0.016711881,
-0.020469509,
0.00914568,
-0.0053816848,
0.006738251,
-0.012400166,
0.0073178173,
-0.0101965405,
-0.015654651,
0.0004685091,
0.011699592,
-0.028634384,
-0.004216184,
0.03928311,
0.01967977,
0.013119847,
0.023348233,
0.0029965474,
0.0128077725,
-0.008101187,
-0.0011010163,
0.0053593935,
0.0049708933,
0.036862947,
-0.0013032275,
-0.002472709,
-0.034697536,
0.01282051,
0.015463586,
0.005391238,
-0.032761402,
0.008980089,
-0.009183893,
-0.01961608,
-0.006528079,
0.007910121,
0.031844288,
0.049473286,
0.004174786,
0.019093836,
-0.0192849,
0.029143892,
0.016877472,
-0.0058020293,
0.027080383,
-0.003445552,
0.0077190553,
-0.016176898,
0.012960625,
0.021106394,
-0.02570471,
-0.020151066,
0.012393797,
0.0084259985,
-0.007846433,
-0.0024551945,
-0.011693222,
-0.018966459,
0.012546649,
-0.0036429865,
-0.014699323,
0.0076999487,
-0.022227313,
0.0037098594,
-0.007419719,
-0.0018883663,
-0.019717984,
0.009317638,
-0.0039614295,
0.00437859,
0.01956513,
0.011393886,
0.003222642,
-0.008642539,
0.005814767,
0.0069484236,
0.0076617356,
-0.016941162,
-0.03495229,
-0.0038117613,
0.0035028716,
0.0072159157,
0.04109187,
0.013998749,
-0.015361684,
-0.01761626,
0.01505598,
-0.035869405,
0.012330108,
-0.011088181,
-0.005391238,
0.0122091,
-0.0019695691,
-0.0029981397,
0.016151423,
0.0039104787,
-0.0034200766,
-0.010540459,
-0.02927127,
0.0114384685,
0.039614294,
-0.027717268,
0.0029567422,
-0.006142763,
0.015005029,
-0.0061459476,
0.004700217,
-0.00273224,
0.004582393,
0.0126803955,
0.00248067,
0.023704888,
-0.00980804,
-0.034086127,
0.0051874346,
0.0053084427,
0.058491588,
-0.00613321,
-0.022775035,
0.024176184,
-0.010674206,
-0.02268587,
-0.10297169,
-0.0058752713,
0.011546738,
0.009394065,
0.008088449,
0.02106818,
-0.0074260877,
0.012463855,
-0.0034264454,
0.03189524,
-0.012368321,
-0.015234307,
-0.016750095,
0.0022147703,
0.031564057,
-0.012457485,
0.02263492,
-0.01432993,
0.013731257,
0.036378913,
0.00696753,
-0.023462871,
-0.0016168937,
-0.029475072,
-0.011572214,
-0.019437753,
-0.012979732,
0.004015565,
-0.013986011,
0.0023357784,
0.010508615,
0.012247313,
-0.016125947,
-0.0014027408,
-0.011476682,
-0.0021478971,
-0.0076617356,
-0.0061841607,
0.015119668,
-0.005228832,
0.014482782,
0.040047377,
0.006289247,
-0.00521291,
-0.015629176,
-0.0071394895,
-0.018966459,
-0.0077572684,
0.0032035355,
-0.006757358,
0.009273057,
-0.037423406,
-0.026265169,
0.0009895612,
0.0054485574,
-0.021437574,
0.02608684,
0.0067509892,
0.019195737,
0.012909674,
0.016877472,
0.022622183,
-0.022558494,
0.006922948,
0.018826343,
-0.030392189,
0.0035347159,
-0.024660217,
0.0061395788,
-0.017221391,
-0.011578583,
0.0030061007,
-0.008464212,
0.00316373,
-0.02085164,
-0.009413172,
-0.030723369,
-0.014546471,
0.008438736,
-0.03204809,
-0.0018612986,
-0.011833337,
0.013438289,
-0.010438558,
0.02045677,
-0.0011726659,
-0.0050919014,
0.009661557,
0.00055886724,
-0.021666853,
0.014342668,
0.037321504,
0.021093655,
-0.013871372,
0.026749201,
0.016801046,
0.012304633,
-0.00869349,
-0.00004099952,
0.0038181301,
-0.013412814,
0.009973631,
-0.035996784,
0.005693759,
0.007961072,
-0.011024493,
-0.017361505,
-0.009616975,
0.019144787,
-0.020877115,
0.009616975,
0.025959464,
0.010381238,
0.031029074,
-0.014444569,
-0.01606226,
-0.022112673,
-0.03181881,
0.014533733,
0.030417664,
0.04539722,
0.0106359925,
0.0033946012,
0.010820689,
0.012616707,
0.0032433406,
-0.0011018123,
0.0050441353,
-0.014533733,
0.016826522,
-0.020673312,
0.001343829,
0.021666853,
-0.024481889,
0.0025873485,
0.008368678,
-0.011502157,
-0.011489419,
-0.013743995,
0.02268587,
0.016406177,
0.020545935,
0.016011307,
-0.012559387,
-0.007101276,
-0.014954078,
-0.013438289,
0.0027545309,
-0.005384869,
0.016648194,
0.012107198,
-0.008285884,
0.004611053,
0.023679413,
-0.0038531588,
-0.03021386,
-0.0122791575,
0.01738698,
0.024876758,
0.007840063,
-0.013909585,
-0.026163267,
0.029704351,
-0.008738073,
0.0074324566,
0.00092826097,
0.03288878,
-0.0221891,
-0.0044422783,
0.0038977407,
-0.0034359987,
-0.03948692,
-0.006142763,
-0.0031430312,
-0.006333829,
-0.0037321504,
0.005591857,
0.00752799,
-0.0122600505,
0.019870836,
0.0016105248,
0.03278688,
0.0065981364,
0.01895372,
-0.03780554,
-0.0035697448,
0.026723726,
-0.0040505934,
-0.02575566,
0.008636171,
0.015782028,
0.011610427,
-0.038213145,
0.012470223,
-0.008820868,
-0.005362578,
0.01979441,
0.014431831,
-0.0061109187,
-0.010279336,
0.014304454,
0.014342668,
-0.0047543524,
-0.0008494464,
-0.046798367,
-0.016711881,
-0.009801672,
-0.00819672,
0.0034423675,
-0.028965564,
-0.01678831,
-0.004257581,
0.025933988,
0.033423763,
-0.028175825,
0.0074897767,
-0.007725424,
0.01660998,
0.010081901,
0.007776375,
-0.009769827,
0.02308074,
0.001136045,
0.0038977407,
-0.018151244,
-0.004305348,
0.018355047,
0.021526739,
-0.0012013258,
-0.0020045978,
0.027003957,
-0.020354869,
0.014444569,
-0.012712239,
-0.026570873,
0.0015540012,
0.0070885383,
-0.035716552,
0.03502872,
0.0061586853,
0.017259603,
0.054058865,
0.006142763,
0.009566024,
0.0010150367,
0.008833606,
0.017144965,
0.025730185,
-0.0062128208,
-0.0067828335,
-0.02313169,
-0.0022816432,
-0.02052046,
-0.006305169,
-0.038722653,
-0.0027290555,
0.037092227,
0.017679948,
0.028328678,
0.01348924,
-0.023144428,
0.004805303,
-0.012788666,
0.019335851,
0.006009017,
-0.016189637,
-0.015463586,
0.028914614,
0.01360388,
-0.0036652775,
-0.024010593,
-0.022482067,
0.014240766,
-0.02302979,
0.00858522,
0.032022614,
-0.016813785,
-0.0055504595,
-0.026570873,
0.008578851,
-0.0055504595,
0.0042798724,
-0.00006816668,
-0.015680127,
0.00036640835,
-0.03367852,
0.0061555007,
-0.016902948,
-0.042849675,
-0.02486402
] |
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. In this study, we describe a strategy for inducing aging-related features in human iPSC-derived lineages and apply it to the modeling of Parkinson's disease (PD). Our approach involves expression of progerin, a truncated form of lamin A associated with premature aging. We found that expression of progerin in iPSC-derived fibroblasts and neurons induces multiple aging-related markers and characteristics, including dopamine-specific phenotypes such as | [
-0.010033966,
0.0049197283,
0.008705941,
-0.022670323,
-0.018458204,
0.015050949,
-0.018713078,
0.019128924,
-0.029940924,
-0.00599288,
-0.0014420472,
0.013883896,
0.00767974,
0.02430688,
-0.022348378,
-0.00083127315,
0.029618979,
-0.005550205,
0.013119276,
0.027901936,
-0.031443335,
0.015949713,
0.022831297,
-0.033026233,
-0.014715589,
0.012770502,
-0.0037962731,
-0.028894601,
-0.0023978227,
0.00079689873,
0.009591291,
-0.016231416,
0.007632789,
-0.010791879,
-0.007968149,
-0.013441222,
-0.0012601145,
-0.024494682,
0.007243772,
-0.014380229,
0.006827926,
0.014715589,
-0.008705941,
-0.012106489,
0.0028991855,
0.0081760725,
-0.014299743,
-0.020295976,
-0.0024934001,
0.016607018,
0.02660074,
0.0045374185,
-0.015614353,
0.009457147,
-0.00077426195,
-0.020604506,
0.012146733,
0.024132492,
0.017358225,
-0.010791879,
-0.0018830453,
0.003688958,
-0.01813626,
0.016204586,
-0.011455892,
0.01557411,
-0.011241261,
0.0010354235,
0.0126967225,
-0.010583956,
0.061115973,
0.0008660667,
-0.006770915,
-0.0058687967,
0.005365757,
0.0016566775,
-0.014004626,
-0.005828554,
0.010054087,
0.012589407,
0.012415021,
-0.034126215,
0.0008996027,
0.022455692,
0.008216316,
0.010651028,
-0.020591093,
0.021543514,
0.023367872,
0.0037627371,
0.01896795,
0.027687306,
0.0050303973,
0.02272398,
-0.013515,
0.0036822509,
0.0027348592,
0.018391132,
-0.014447301,
-0.008907157,
-0.024159322,
0.013561951,
-0.009530926,
-0.019102095,
-0.02760682,
0.0021395956,
0.017049693,
-0.0007751004,
0.029404348,
0.000068067566,
-0.015708255,
0.02641294,
0.013555244,
-0.02980678,
0.01636556,
-0.016808234,
0.0116504,
0.017519196,
-0.011737593,
-0.016727747,
0.034743275,
0.018431375,
0.02000086,
-0.02495077,
0.008115708,
-0.006043184,
-0.016419217,
0.007565717,
-0.019745985,
0.0017807606,
-0.002419621,
0.0012852665,
-0.0061940956,
0.018404547,
-0.029484835,
-0.013313784,
0.0013959352,
-0.019652085,
-0.023220314,
-0.026775127,
-0.0056038625,
0.014581445,
-0.023099585,
-0.0011838202,
-0.014621688,
0.0072504794,
0.016633848,
0.004966679,
0.025312958,
0.020658165,
-0.003221131,
0.010671149,
0.017693583,
-0.020416705,
-0.007485231,
0.028411683,
0.024172736,
0.026010508,
-0.018619176,
0.007820591,
0.0010907578,
-0.01114736,
0.0039371243,
0.01844479,
-0.0044602854,
0.02165083,
-0.010181524,
0.015802154,
0.0066132955,
-0.0014445625,
-0.02076548,
0.02892143,
-0.04131633,
0.017398467,
-0.004098097,
0.008544968,
-0.0016223032,
0.010416276,
-0.030611644,
-0.041799247,
-0.0116504,
0.03141651,
0.011704057,
0.01768017,
0.007451695,
0.014098527,
0.027043415,
-0.020363048,
-0.008773013,
-0.021811802,
-0.006770915,
0.006583113,
-0.0021060596,
-0.012240633,
-0.6340178,
-0.05719897,
0.010114452,
-0.011838201,
0.023139827,
0.039465144,
0.014165599,
-0.0214362,
-0.02635928,
0.029001918,
0.006552931,
0.011241261,
0.0072035287,
-0.009108373,
-0.008135829,
-0.023528844,
0.001701951,
-0.027016588,
0.016083857,
0.013561951,
-0.022804467,
0.013226591,
-0.0029092464,
0.020403292,
0.01105346,
0.02098011,
0.02476297,
-0.021704488,
-0.009383367,
0.03138968,
-0.012482093,
0.023528844,
-0.013005254,
-0.013528415,
0.050464947,
0.0017958519,
-0.010194939,
0.023019098,
0.028572656,
0.05870138,
0.0015971512,
0.015761912,
0.012428435,
0.003246283,
-0.030933589,
0.012770502,
0.006083427,
0.0016114039,
0.014809489,
-0.006385251,
0.023542259,
0.021342298,
-0.021114254,
-0.003454206,
0.017532611,
0.0016373943,
0.014621688,
-0.012213805,
0.033750612,
-0.010409568,
0.014916805,
0.037077382,
-0.023166656,
0.011757715,
-0.008256558,
0.026305623,
0.0036420075,
-0.0070827994,
0.00029197262,
-0.0342067,
0.00696207,
0.03393841,
-0.025688563,
0.004601137,
-0.0015166647,
0.015158264,
-0.0064724446,
-0.003930417,
-0.013910725,
-0.005623984,
0.004074622,
-0.0060633053,
-0.024776382,
0.023783717,
0.015426552,
0.00544289,
-0.019061852,
0.019558184,
-0.025769047,
0.017613098,
0.027714135,
0.0024749555,
0.018525276,
-0.054838035,
-0.014755832,
0.00081198994,
-0.0037157869,
-0.0070492635,
-0.0061639133,
-0.02574222,
-0.0052617956,
0.0019098741,
0.017425297,
0.015641183,
0.037613958,
0.021624,
-0.037801757,
0.009597998,
0.039894402,
-0.02430688,
0.0061069024,
-0.014098527,
-0.00485601,
-0.01557411,
-0.025460517,
-0.019732572,
0.011294918,
-0.019142339,
-0.0051310053,
-0.012354655,
0.005171248,
-0.01490339,
-0.006693782,
0.03393841,
0.00062544603,
0.0022167284,
-0.004128279,
0.008887035,
-0.004212119,
0.0030165615,
-0.0011326778,
-0.022348378,
0.007867541,
-0.030611644,
0.024132492,
-0.008202901,
0.0072169434,
-0.014541201,
0.0163119,
-0.0057883104,
-0.035199367,
0.0011963962,
0.003212747,
-0.003162443,
-0.019437455,
-0.026023922,
-0.014487544,
-0.022589836,
0.016553361,
0.013240006,
-0.00350451,
-0.0080083925,
-0.014621688,
0.0062276316,
0.008404117,
-0.011965638,
-0.011509549,
-0.032838434,
0.0062477533,
-0.014943633,
-0.026466597,
0.042443138,
-0.02232155,
0.007317551,
0.004614551,
-0.015426552,
-0.009812628,
0.01847162,
-0.02571539,
-0.02128864,
-0.008088878,
-0.010999802,
-0.0058956253,
0.008524846,
0.014152184,
0.013816824,
0.011160775,
-0.010248596,
-0.0098394565,
-0.013213176,
-0.013461343,
-0.025728805,
0.004339556,
-0.007934613,
0.031738453,
0.01566801,
0.034126215,
0.011107117,
-0.01122114,
0.036996894,
0.008940693,
0.03750664,
0.01597654,
0.009101666,
0.008417531,
-0.010879072,
-0.00017218631,
0.0009247547,
0.0035917037,
0.01468876,
0.008162658,
-0.026144652,
0.011945517,
-0.016150929,
0.008410824,
-0.03554814,
-0.0016876983,
-0.026640983,
0.0050974693,
0.021422785,
-0.0053959396,
0.013950968,
-0.021355713,
-0.016969206,
0.001844479,
0.008028514,
-0.006318179,
-0.005623984,
-0.0052517345,
-0.009812628,
-0.013387564,
0.012435142,
0.002847205,
-0.018002115,
-0.0036420075,
0.033214036,
0.0017908214,
0.033723783,
0.02210692,
-0.013675973,
0.013501586,
0.020014273,
-0.0007273116,
0.023287386,
0.0038767594,
0.021811802,
0.008169365,
-0.005305392,
0.049364965,
0.004480407,
0.006549577,
0.013219884,
0.010604077,
0.010704685,
-0.0100071365,
-0.001313772,
0.04416018,
0.016231416,
-0.012542457,
0.029082403,
-0.033455495,
0.015426552,
-0.027378775,
0.002937752,
-0.0023039219,
-0.021583758,
0.006351715,
0.0029595504,
0.018417962,
0.0287068,
0.011509549,
-0.008712648,
-0.006016355,
-0.014957048,
0.002679525,
-0.0035145709,
0.007317551,
-0.0099065285,
-0.0073712086,
0.005271856,
-0.011543085,
0.0017740534,
0.0074584023,
-0.051833212,
0.0037426155,
-0.005271856,
0.018565519,
0.0031221998,
0.036809094,
-0.0021328884,
0.00468833,
-0.0268422,
0.019048437,
0.023072755,
-0.011281504,
-0.0050270436,
-0.027217802,
-0.022764225,
0.0023408115,
-0.016741162,
-0.004798999,
0.020135004,
0.0013841976,
0.0035011566,
-0.0012877816,
-0.011677229,
0.01713018,
-0.002520229,
0.010335789,
-0.009215687,
-0.0019886836,
0.013722924,
0.0055032545,
-0.021664243,
0.015842397,
0.025916606,
-0.0068648155,
-0.01746554,
-0.008035221,
-0.017157009,
-0.024494682,
-0.01875332,
0.003353598,
-0.00075959,
-0.009980308,
0.001919935,
0.012502214,
-0.005523376,
0.036299348,
-0.0016415863,
-0.0057044704,
-0.032328688,
-0.022643495,
-0.0016499703,
0.02574222,
0.024548339,
0.0076260823,
-0.000005780372,
0.009249223,
0.0052148453,
0.0035682283,
-0.030397013,
0.03136285,
-0.018927708,
0.007002313,
-0.008451067,
0.014621688,
-0.011623572,
0.0058050784,
0.026775127,
0.008793134,
-0.03820419,
-0.019169167,
-0.00523832,
0.00015667592,
-0.0007298268,
0.016835062,
0.052584417,
0.032865264,
-0.0035615212,
0.022978855,
0.013857068,
-0.012958303,
-0.012716844,
-0.02983361,
0.0035782892,
0.012113197,
0.011241261,
0.004765463,
-0.020778894,
0.023005683,
0.021369128,
0.00906813,
0.025487347,
0.017639926,
0.01844479,
0.005848675,
-0.008866914,
0.0024045298,
0.005999587,
-0.024266636,
-0.005566973,
-0.011281504,
-0.035816427,
0.023408115,
-0.022039847,
-0.02485687,
-0.014527787,
0.020725237,
0.0025437041,
0.006928534,
-0.024145907,
0.0013707832,
-0.014071697,
0.0015057656,
-0.03273112,
0.016607018,
0.000024745887,
0.007284015,
-0.022348378,
0.0052819173,
-0.0033569518,
-0.013937554,
-0.010362619,
0.012240633,
-0.019692328,
-0.031255536,
0.015185093,
-0.0040545003,
0.025916606,
0.014366815,
-0.01878015,
0.009202274,
0.017854556,
0.0018981366,
-0.022710567,
0.0060230624,
-0.013789996,
0.01731798,
0.01710335,
0.0031389678,
-0.015533866,
-0.01679482,
0.0115028415,
0.028358025,
-0.0073041366,
-0.0013087416,
-0.0015535543,
-0.02650684,
0.0005889757,
0.041665103,
0.016378973,
-0.021637416,
-0.008793134,
0.007941321,
-0.035762772,
-0.021060597,
-0.026292209,
-0.02660074,
-0.02892143,
-0.0101077445,
-0.008484603,
-0.018082602,
-0.021208154,
0.016754577,
-0.006150499,
0.022589836,
0.008726062,
0.017022865,
0.012804038,
-0.0033821038,
0.007827298,
0.0141924275,
-0.007351087,
-0.003321739,
-0.007907785,
0.054864865,
0.002770072,
-0.014514373,
-0.0096382415,
0.021302056,
-0.011214432,
-0.018216746,
-0.004064561,
-0.010972973,
0.04126267,
-0.013789996,
-0.0306653,
-0.029243376,
-0.013018668,
0.00044183654,
0.015480209,
0.011261382,
-0.023797132,
0.004128279,
0.0012944889,
0.002754981,
0.000669462,
0.033160377,
-0.038391992,
-0.007787055,
0.015708255,
0.026131237,
0.011247968,
-0.009691899,
0.020443534,
-0.0027315058,
-0.00818278,
-0.016258243,
-0.008940693,
0.02012159,
-0.016446045,
0.03801639,
0.03393841,
0.042496797,
0.010993095,
0.0030232687,
0.029699465,
0.009148615,
0.0045105894,
0.004031025,
0.014474129,
-0.010248596,
0.01676799,
0.001953471,
0.008699234,
0.02033622,
-0.034340844,
0.024937356,
0.013266834,
-0.0062544607,
-0.029270204,
0.006827926,
-0.043355316,
-0.050035685,
-0.00078096916,
-0.01633873,
-0.008625454,
-0.030262869,
0.018833807,
0.00046111975,
0.008860206,
-0.009886407,
0.013400978,
0.021972775,
-0.0030953712,
0.025017843,
0.0038767594,
0.010537005,
-0.0025839473,
-0.011791251,
-0.0070693847,
0.016137514,
0.015265578,
-0.01533265,
0.00350451,
0.0040880363,
-0.020363048,
-0.0009960186,
0.022173991,
-0.026493425,
-0.015654596,
-0.032355513,
-0.0320604,
-0.0042020585,
-0.027325118,
-0.020497192,
-0.022670323,
0.00010705314,
0.00844436,
-0.02385079,
0.012039417,
-0.010711392,
-0.016902134,
0.018283818,
-0.007880956,
0.0005608893,
-0.010664443,
0.02442761,
0.026989758,
0.007954734,
-0.026480012,
-0.014983877,
-0.000041107778,
0.018914293,
0.018149674,
0.0134211,
-0.020658165,
-0.038472477,
-0.008337045,
-0.0052517345,
-0.037882246,
-0.027070245,
0.010275424,
-0.0022016373,
-0.009826043,
0.004074622,
-0.0035917037,
-0.021476442,
-0.0015929592,
-0.015466794,
0.019544771,
0.012461971,
-0.003320062,
-0.014487544,
0.0057681887,
-0.00607672,
0.01055042,
0.020926453,
-0.018364303,
-0.010221767,
-0.021328885,
0.0040880363,
0.003328446,
-0.0037157869,
0.016110685,
-0.015963128,
0.009088251,
0.011033338,
0.013139398,
0.01700945,
0.01220039,
0.0024816627,
0.042389482,
-0.023220314,
-0.0013322169,
0.0036654829,
-0.007834005,
-0.0039203563,
-0.008236437,
-0.0048928997,
-0.007901077,
-0.022683738,
-0.020175247,
0.030316528,
-0.0016608695,
0.0006480828,
0.009423611,
-0.025393445,
0.013172934,
-0.017170422,
-0.035199367,
0.009014471,
-0.043248,
0.0050941156,
-0.011972345,
0.04421384,
0.017049693,
0.004339556,
0.0011569913,
0.01535948,
0.023327628,
-0.013749752,
0.026292209,
-0.00009484395,
0.006492566,
-0.009577876,
0.011911981,
-0.01533265,
0.00219493,
0.00061622367,
-0.019813057,
-0.031201877,
0.0015569079,
-0.0010622522,
0.028545827,
0.010630907,
-0.015386309,
0.0055703265,
0.007076092,
0.00839741,
0.002796901,
-0.036513977,
-0.012837574,
-0.006784329,
0.014930219,
-0.004983447,
-0.01700945,
0.004916375,
-0.025862949,
-0.0045240037,
0.018793564,
-0.022844711,
-0.015949713,
-0.002344165,
0.006894998,
-0.013883896,
-0.0005252573,
-0.01645946,
-0.015600938,
-0.022871539,
0.010617492,
-0.004882839,
-0.0076394966,
-0.04456261,
0.017277738,
0.017210666,
0.0032814958,
0.00485601,
0.00048836775,
-0.013058911,
-0.031872597,
-0.01844479,
-0.0054361825,
-0.024253221,
0.042389482,
0.043865062,
0.0018830453,
-0.022334963,
-0.014246085,
-0.061062314,
-0.027445847,
0.008591918,
0.0032697583,
0.0015694839,
-0.0019735924,
-0.018766735,
-0.0026074226,
0.011201018,
0.012126611,
0.004295959,
-0.02385079,
0.019397212,
-0.013320492,
0.004755402,
0.010329083,
-0.017049693,
-0.011643693,
0.016177757,
0.0035078637,
-0.008860206,
0.006418787,
-0.0044736997,
0.038096875,
-0.01600337,
0.023931276,
0.023314215,
-0.00027457584,
0.013333906,
-0.013789996,
-0.020389877,
0.014272913,
-0.0096382415,
-0.0027180912,
0.00031712462,
-0.0062913503,
-0.0060297693,
-0.009987015,
0.0010429691,
-0.024387365,
0.001978623,
-0.005399293,
0.018283818,
-0.014232671,
0.013286956,
0.018243574,
0.01636556,
0.0045072357,
-0.018082602,
0.007076092,
-0.0102083525,
-0.014272913,
0.010322375,
-0.0053691105,
0.0019652084,
0.0027851632,
0.0021245044,
-0.026345868,
-0.019477699,
-0.01270343,
-0.0142594995,
0.00032068783,
0.03141651,
-0.00074533717,
-0.013709509,
-0.008021806,
-0.0025017841,
-0.008793134,
-0.023260556,
0.00029574544,
-0.0054697185,
-0.033750612,
0.012649772,
-0.00502369,
-0.007994978,
-0.0030987246,
0.010496763,
-0.0049297893,
0.015185093,
0.011086996,
0.19767448,
-0.0065462235,
0.0063215327,
0.000098459546,
0.022509351,
0.016177757,
0.01908868,
-0.0070962138,
-0.014487544,
0.006861462,
0.014179013,
0.00016485031,
-0.0115699135,
-0.0019685621,
0.009926651,
-0.022160577,
-0.0050874082,
-0.0037426155,
-0.03163114,
-0.022455692,
0.020470364,
-0.034367673,
0.013018668,
0.0019551478,
0.018377718,
-0.010530299,
-0.01875332,
0.010543712,
0.025809292,
0.017197251,
-0.016969206,
0.00082456594,
0.0031825646,
-0.006566345,
-0.0049599716,
-0.022267891,
-0.006583113,
-0.018686248,
0.0073242583,
-0.007243772,
0.01997403,
-0.0037526763,
0.006318179,
-0.0028069615,
-0.005811786,
-0.0005055549,
-0.0053288676,
-0.0026258673,
0.023797132,
-0.009785799,
-0.04751378,
0.0030685423,
0.009584583,
0.01253575,
0.0063550686,
-0.0083772885,
-0.0063818973,
0.031872597,
0.0007126396,
0.017411882,
-0.011724179,
0.005117591,
-0.01581557,
-0.0009012795,
-0.019692328,
0.026547084,
-0.0051645413,
-0.0016449399,
0.011167482,
-0.016835062,
-0.014970462,
-0.0063282396,
-0.010838829,
0.0017589622,
-0.0025738867,
-0.03466279,
0.056823365,
0.016580189,
0.031818938,
0.027875109,
0.004024318,
0.018739907,
-0.03004824,
-0.007733397,
-0.012005881,
-0.046011366,
0.045796737,
0.008544968,
-0.04131633,
-0.024239808,
0.009524219,
-0.01401804,
-0.011107117,
-0.010899194,
-0.011449184,
0.0018578934,
0.014957048,
0.0064623835,
0.009658363,
-0.010610784,
-0.019745985,
0.06857438,
0.0031305838,
0.0035447532,
-0.015547281,
0.013689388,
0.00818278,
0.003521278,
-0.013991212,
-0.021570344,
-0.010241888,
-0.023139827,
0.016996035,
-0.023864204,
0.0014319865,
0.031040905,
0.007834005,
-0.025460517,
0.054918524,
-0.0059056864,
-0.0010496762,
-0.026815372,
-0.021449614,
0.025782462,
-0.0040679146,
-0.0028254064,
-0.0021748084,
-0.0031372912,
-0.032382343,
-0.01796187,
-0.0034173166,
-0.004916375,
0.001995391,
-0.002620837,
-0.0008702587,
-0.0155875245,
0.01181808,
-0.004738634,
0.0011787898,
0.011328454,
-0.014715589,
0.0009423611,
0.009128494,
-0.009410196,
0.0033016175,
-0.00042402057,
0.010845536,
0.017331395,
0.020161832,
-0.024508094,
-0.012294291,
-0.023180071,
0.0034407917,
0.005566973,
0.015265578,
-0.0073577943,
-0.01801553,
-0.0060465373,
-0.016043613,
0.012267462,
-0.040055376,
0.041182186,
-0.0031490286,
0.0031758575,
-0.009269346,
-0.013313784,
-0.1693433,
-0.007820591,
0.02538003,
-0.032489657,
0.019169167,
0.0055133156,
0.015118021,
-0.02760682,
-0.012401606,
0.012850988,
0.021825217,
0.0010421306,
-0.044294324,
-0.022147162,
0.01181808,
0.029753122,
-0.016821649,
0.050008856,
0.006656892,
0.0009088251,
0.022522764,
-0.0160302,
0.012904646,
-0.00024607027,
-0.018042358,
-0.01933014,
0.009074837,
-0.020497192,
-0.018874051,
-0.04284557,
-0.014313157,
-0.0050438116,
0.033670124,
-0.009336418,
-0.007941321,
-0.0045374185,
-0.007418159,
-0.021141082,
-0.0020238964,
0.016164344,
0.021087425,
0.037238352,
0.012804038,
0.010630907,
0.0071699927,
0.039438315,
-0.0018511862,
-0.013367442,
0.017894799,
-0.013729631,
0.021355713,
-0.01667409,
0.0054294756,
0.020537434,
0.009115079,
0.01844479,
0.022013018,
-0.0077937623,
-0.01114736,
-0.014179013,
-0.020108175,
0.015278993,
0.036755435,
0.003722494,
0.016016785,
-0.023582501,
0.0018310646,
-0.0012165178,
-0.021328885,
0.015989956,
-0.009651655,
-0.013112568,
-0.003705726,
-0.015064362,
0.03273112,
0.0003628174,
-0.010543712,
0.00822973,
-0.012978425,
-0.0030635118,
-0.023367872,
0.03246283,
-0.02913606,
-0.00342067,
-0.022187406,
0.011026631,
0.017089937,
0.020550849,
-0.016955793,
-0.013354028,
0.016150929,
-0.0142594995,
0.016607018,
0.010724807,
0.019920373,
0.013843653,
-0.009960187,
-0.010228475,
-0.003405579,
-0.004634673,
0.011690643,
-0.0012877816,
-0.01016811,
0.009826043,
0.057574574,
-0.0028237295,
-0.033053063,
0.011563206,
0.04424067,
-0.0063986653,
-0.012596115,
-0.0029612272,
0.0047084517,
0.015775325,
-0.004041086,
0.03399207,
-0.0040511466,
0.012495507,
-0.008893742,
-0.008652283,
0.06455006,
-0.0037191403,
0.0102083525,
0.039196856,
0.0012475385,
-0.004567601,
-0.13435856,
-0.017492369,
-0.00084384915,
0.011824787,
-0.007719983,
0.015989956,
0.010785172,
0.024722725,
-0.029779952,
0.012877817,
-0.006502627,
-0.029699465,
0.01186503,
-0.0128308665,
0.004654794,
-0.019195996,
0.0011326778,
0.010369325,
-0.03358964,
0.039170027,
-0.015091192,
0.0077736406,
0.0023055987,
-0.012267462,
-0.0023659635,
0.028250711,
-0.033723783,
0.03273112,
0.014769246,
0.04590405,
0.0043026665,
-0.00818278,
0.006995606,
0.021784974,
-0.0073242583,
-0.015600938,
0.003963953,
-0.022053262,
0.032596976,
-0.018096015,
0.0026644338,
0.00009122835,
-0.008632162,
0.011194311,
0.00409139,
-0.0094370255,
-0.0076596183,
0.0033603054,
0.011898566,
-0.014474129,
-0.04289923,
-0.029484835,
-0.004466993,
-0.012978425,
0.006043184,
-0.038365163,
0.013266834,
0.014849733,
-0.0101077445,
-0.007860834,
-0.013488172,
-0.01287111,
-0.022670323,
-0.023408115,
0.018525276,
-0.030531157,
-0.023528844,
-0.044026036,
0.02229472,
-0.0061940956,
-0.022334963,
-0.010355911,
-0.012347949,
0.0072907223,
-0.0077401046,
0.0054294756,
0.011999174,
-0.015319237,
-0.0025554418,
0.0048928997,
-0.008001685,
-0.021181326,
0.018874051,
-0.017626513,
0.01801553,
0.016204586,
0.010262011,
-0.008430946,
-0.0029981167,
-0.0071699927,
-0.0023022452,
0.028867774,
-0.016110685,
-0.0037593835,
-0.006817865,
-0.0006941948,
-0.008202901,
-0.019383797,
0.025125157,
0.023716645,
-0.02476297,
-0.0063651293,
-0.052450273,
0.014930219,
0.006928534,
-0.00139342,
-0.013937554,
-0.014648517,
-0.00025214866,
-0.017881386,
0.007002313,
-0.010496763,
-0.0021748084,
0.0072706006,
-0.013857068,
-0.006774268,
-0.023676403,
-0.023542259,
0.0375603,
-0.010194939,
0.014541201,
0.022764225,
0.007699861,
0.004500529,
0.003464267,
0.000673654,
-0.007210236,
-0.008551675,
-0.014608273,
0.032409173,
0.0036654829,
-0.010342496,
0.010724807,
-0.045152847,
-0.021154497,
-0.0032010095,
0.0005126813,
0.00063047645,
0.03361647,
0.025447102,
0.01765334,
0.03686275,
-0.001101657,
-0.04153096,
0.0140582835,
-0.0041383402,
-0.0080083925,
0.0070962138,
-0.026198309,
0.0012793978,
0.021489857,
-0.008296802,
0.03069213,
0.0047587557,
-0.012716844,
-0.009215687,
-0.0032093935,
-0.013655852,
0.010463227,
0.018605763,
0.0014110265,
0.000042260577,
0.006576406,
0.007713276,
0.014970462,
0.0030517743,
-0.028867774,
-0.016848477,
-0.04260411,
0.012300998,
-0.012140025,
-0.02045695,
-0.0081090005,
0.026640983,
0.022764225,
0.0036788972,
0.014621688,
-0.011201018,
-0.012448557,
0.0023626098,
-0.0072907223,
0.00667366,
0.012777209,
0.023233728,
-0.02873363,
0.016553361,
0.02935069,
0.012522335,
-0.013441222,
0.031255536,
0.0063818973,
-0.00015332231,
0.0013749752,
-0.0037258475,
-0.0017874679,
0.020483777,
0.00599288,
-0.0009063099,
-0.017143594,
0.019142339,
0.009490683,
0.013729631,
0.011657108,
0.00266108,
0.007143164,
-0.02061792,
-0.012502214,
0.012233926,
-0.024226394,
-0.022563009,
-0.0031473518,
-0.0039505386,
0.009061422,
0.0071699927,
-0.019209411,
0.008806549,
-0.014836318,
0.0074382806,
-0.0010153018,
-0.0057011168,
-0.009135202,
0.030262869,
0.017948458,
-0.0048023527,
0.01330037,
0.022536179,
-0.0022586484,
-0.0048526567,
0.016700918,
-0.025245886,
0.026627569,
-0.01287111,
0.039679773,
-0.0071029207,
-0.016446045,
-0.01557411,
-0.009195566,
-0.025809292,
-0.012461971,
0.02186546,
-0.025634903,
0.082203396,
0.009577876,
-0.013582072,
-0.0023324275,
-0.018820392,
0.01093273,
-0.00026053266,
0.014822904,
-0.047862552,
-0.03471645,
0.019477699,
-0.032087225,
0.017894799,
-0.022589836,
-0.011522964,
0.01578874,
-0.004822474,
0.017170422,
-0.024991013,
-0.021328885,
0.016660675,
-0.0016256567,
0.018739907,
0.013991212,
-0.01942404,
-0.013897311,
0.01896795,
-0.005982819,
0.0026325746,
-0.012817452,
0.012233926,
0.0099736005,
-0.029860439,
-0.007632789,
0.008759598,
0.004279191,
-0.002186546,
-0.021919118,
0.013441222,
0.012609529,
-0.014085112,
0.012233926,
-0.015319237,
0.003963953,
-0.0024732787,
-0.009255931,
0.004339556,
-0.01502412,
-0.0062645213
] |
Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as key components of protein complexes that drive membrane fusion. Despite considerable sequence divergence among SNARE proteins, their mechanism seems to be conserved and is adaptable for fusion reactions as diverse as those involved in cell growth, membrane repair, cytokinesis and synaptic transmission. A fascinating picture of these robust nanomachines is emerging. | [
-0.028099298,
-0.0090583265,
0.011857692,
-0.016981062,
-0.002451096,
0.008193428,
-0.0032730796,
0.012247227,
-0.016730174,
-0.02358334,
0.011454954,
0.03190221,
0.018829698,
0.009573304,
0.010583453,
0.0035190145,
0.021100882,
-0.0014104118,
-0.016611334,
-0.013970422,
-0.021576246,
-0.00993643,
-0.001616733,
-0.03253603,
0.0030882158,
0.02399268,
0.009877008,
-0.029631026,
-0.014366559,
-0.023662567,
-0.0015696917,
-0.0009870407,
-0.010259941,
0.0024989625,
-0.018644834,
-0.014234513,
0.0076388363,
-0.012194409,
-0.007110654,
-0.019265449,
0.018248698,
0.015158832,
-0.01700747,
0.00947427,
-0.015779447,
-0.008391496,
0.005030936,
0.0047470382,
-0.013197955,
0.009817588,
0.021246133,
0.0045291632,
-0.023636157,
0.0064306194,
-0.0032994887,
-0.02860107,
-0.012973477,
0.025115067,
0.018710857,
-0.03367162,
-0.016320832,
0.002995784,
-0.0056020333,
0.005836414,
0.004004282,
0.04236022,
0.00016691386,
-0.006133517,
-0.008167019,
0.006846563,
0.030660981,
0.023187203,
0.028416207,
-0.012035954,
0.023306044,
-0.016915038,
-0.00055913045,
-0.016056743,
-0.022276089,
0.026976911,
-0.007777484,
-0.015132423,
0.0056779594,
0.03427903,
-0.0044565382,
-0.023173997,
0.029446162,
0.0044598393,
-0.000833125,
0.01179167,
0.013409228,
0.051101636,
-0.009223383,
0.00168028,
-0.02074436,
0.023649363,
-0.0017743624,
0.015172036,
-0.007652041,
-0.011375726,
-0.018525993,
0.013468648,
-0.013019693,
-0.027623935,
-0.017377198,
-0.009236588,
0.015013582,
-0.02312118,
0.0062820683,
-0.0140628535,
-0.002819173,
0.015753036,
-0.018592017,
-0.022553384,
0.02283068,
-0.0020533088,
0.01923904,
-0.012742397,
-0.00394156,
-0.023913452,
0.027029729,
0.010893759,
0.018103449,
-0.035889987,
0.03755376,
0.0056086355,
0.0056515504,
-0.007889723,
-0.0008120803,
-0.028125707,
-0.0026953802,
0.023160793,
-0.0027250906,
0.00046133422,
-0.013957217,
0.010920169,
0.0015168735,
-0.008549951,
0.0064174146,
-0.024468044,
0.004644703,
0.035625897,
-0.030740209,
-0.00895269,
-0.0037996112,
0.02683166,
0.029763073,
0.01416849,
0.0026722723,
0.0104183955,
0.026976911,
0.0055492152,
-0.008464121,
-0.008840451,
0.020849995,
0.02474534,
-0.0061434205,
0.025115067,
-0.024692522,
-0.01669056,
-0.000013217453,
-0.0020896213,
0.011930318,
-0.012755603,
0.012920659,
0.015871879,
-0.0055327094,
-0.0031938523,
0.003079963,
-0.019027768,
0.0016406663,
0.010590055,
-0.021404587,
0.021827133,
-0.00130395,
-0.0074077565,
0.02129895,
0.006892779,
-0.029129254,
-0.03314344,
0.008681997,
-0.0017743624,
0.03280012,
0.0011355919,
-0.007922734,
-0.016268015,
0.04478986,
-0.0078237,
0.018935336,
-0.012346261,
-0.00008629385,
-0.007896326,
-0.017575266,
-0.011686034,
-0.6401569,
-0.02448125,
0.0039712708,
-0.013600694,
-0.013204557,
0.039455216,
0.015845468,
0.017680902,
0.004740436,
0.015079604,
-0.027544707,
0.012134988,
0.01700747,
-0.016373651,
-0.025735682,
-0.023966271,
-0.0093026105,
-0.011811476,
0.032245528,
0.006833358,
-0.034516715,
0.012570739,
-0.005776994,
0.030317664,
0.019674791,
-0.019780427,
0.011065419,
-0.010358975,
-0.013653512,
0.012881045,
-0.02341168,
0.0118774995,
-0.020123744,
0.000002638655,
0.03871576,
0.023160793,
0.0015779446,
0.050784726,
0.031189164,
0.028389798,
-0.0050573456,
-0.00805478,
-0.008213235,
0.015792651,
-0.011527578,
-0.007929336,
0.011831284,
-0.004070305,
-0.0011884101,
-0.033882894,
0.01717913,
0.010603259,
-0.012445295,
0.004525862,
-0.018961744,
0.009962838,
0.036576625,
-0.014604241,
0.024137931,
0.017522447,
-0.0063546933,
0.014538217,
-0.0037038783,
-0.010880555,
-0.0062028407,
0.00993643,
-0.028469026,
-0.004849374,
0.01938429,
0.011124839,
0.0031641421,
0.014326945,
0.0018535898,
0.000714284,
-0.0063844034,
0.04534445,
-0.0055327094,
0.012134988,
0.00032330534,
0.010524032,
0.0039448617,
0.0032004546,
-0.012947069,
-0.027029729,
0.014089263,
0.012009545,
-0.022064814,
0.03874217,
0.023900248,
-0.013534672,
-0.0030964687,
-0.011250283,
0.004624896,
-0.055036593,
-0.023596544,
0.016294423,
-0.012597147,
-0.015779447,
0.0057010674,
-0.0039943787,
0.0056053344,
-0.023662567,
0.008569757,
-0.030476118,
0.023649363,
0.011785068,
-0.035916395,
0.03393571,
0.050652683,
-0.015832264,
0.0011917113,
-0.009659134,
-0.007902928,
-0.019503132,
-0.027201388,
-0.02329284,
0.011870897,
0.020150155,
0.009863804,
-0.03153248,
0.004641402,
-0.013996831,
-0.01193692,
0.010972987,
-0.0013419131,
0.0018222289,
0.00828586,
-0.013514864,
-0.009830792,
-0.013666716,
0.013693126,
0.00518609,
0.00057522353,
-0.0056086355,
0.0041858447,
0.02952539,
0.003372114,
0.011606806,
-0.009527088,
-0.03731608,
-0.000021263979,
-0.0027102353,
-0.0024709029,
-0.014326945,
-0.006628688,
-0.015462536,
-0.012927261,
-0.010378782,
0.02132536,
-0.030053573,
0.021800725,
0.0030238435,
-0.0054699876,
-0.010306157,
0.015687015,
-0.0017430015,
-0.025445182,
-0.02207802,
-0.0074077565,
-0.013514864,
-0.011494567,
0.01141534,
-0.0431789,
0.019371085,
-0.0061500226,
-0.032720894,
0.021787519,
0.015264468,
0.00417264,
-0.04362786,
0.011600204,
-0.020995246,
-0.024230363,
0.0324568,
0.010999396,
0.030634573,
-0.008800837,
0.017826153,
0.025973365,
-0.014392967,
0.003835924,
-0.027148569,
-0.026092205,
-0.0024213856,
0.025035841,
0.013600694,
0.03876858,
-0.009976043,
0.01402324,
0.009091337,
-0.0159379,
0.0031129743,
0.009428054,
0.017311174,
-0.006060892,
-0.019291857,
0.00099942,
0.0022315702,
-0.012029352,
0.03734249,
0.00924319,
-0.016941447,
-0.013263978,
-0.01822229,
0.00976477,
-0.0054039652,
0.00081290555,
-0.013613898,
-0.0056284424,
0.00982419,
0.011725646,
-0.004885686,
0.018592017,
-0.020480268,
0.02187995,
0.022474157,
-0.0025748888,
0.0072096884,
-0.036735076,
-0.0072889156,
0.015726628,
-0.0045093563,
0.013653512,
0.00086159736,
-0.015383309,
0.019767223,
0.011072021,
0.030660981,
-0.0063745,
-0.022130838,
0.005757187,
0.0087678265,
0.023187203,
0.022526974,
-0.0015482344,
0.0019740814,
0.019252244,
-0.0023454595,
0.0405644,
0.004671112,
-0.00079805043,
0.008034973,
0.0012263732,
0.0010068475,
-0.004100015,
-0.0000051709253,
0.002413133,
0.0013947313,
0.0078237,
0.012484909,
-0.023622952,
0.006754131,
-0.010827737,
0.011237078,
-0.019555949,
-0.026501546,
0.006209443,
-0.002581491,
0.03404135,
0.0097383605,
-0.0046546063,
-0.009038519,
-0.004047197,
-0.009480872,
-0.0002793589,
0.001871746,
0.008312269,
-0.0041132197,
0.005054044,
-0.0027250906,
-0.029789481,
0.0130395,
0.002749849,
-0.01776013,
0.022698633,
0.014419377,
0.009540292,
0.012042556,
-0.003885441,
0.027201388,
-0.009282804,
-0.02382102,
0.02743907,
-0.0075728134,
-0.021774314,
-0.00060947286,
-0.04238663,
0.02106127,
-0.02297593,
0.00692579,
0.008886667,
0.020348223,
-0.011151249,
0.0057934993,
-0.010266543,
-0.013481853,
0.03607485,
-0.02717498,
0.0122142155,
-0.009989248,
-0.0043707085,
0.0061038067,
-0.020533087,
-0.0062622614,
0.024652908,
0.00091276504,
-0.007889723,
-0.011091828,
0.0059387498,
-0.016532106,
0.014221308,
-0.0009688844,
0.0036939748,
-0.015026786,
-0.006853165,
-0.0032846336,
-0.023543725,
-0.0033770655,
0.025669659,
0.017192334,
-0.0063183806,
-0.022011997,
0.022236474,
0.0013006489,
0.034965668,
0.03515053,
-0.00073532877,
0.026818456,
0.01654531,
-0.001689358,
-0.01150117,
-0.019186221,
0.014076058,
-0.01952954,
0.0016126066,
-0.029261298,
0.0061269146,
-0.0009466017,
-0.00039716833,
0.026012978,
0.002842281,
-0.0011999641,
0.004928601,
-0.01741681,
0.015515354,
0.01037218,
0.026858069,
0.028231343,
0.000011250953,
-0.010451407,
0.008411303,
0.04978118,
0.0006820979,
-0.025273522,
0.008681997,
0.016849015,
-0.0077114613,
0.0021985588,
-0.03253603,
-0.037184034,
0.016096355,
0.029023618,
0.012280238,
0.02981589,
-0.0086687915,
0.00020879706,
0.011052215,
-0.00466451,
0.0051530786,
-0.013145137,
0.02952539,
-0.002358664,
-0.012293443,
0.0010794726,
0.022011997,
-0.029366935,
0.011725646,
-0.013798762,
0.0010761714,
-0.019225836,
0.007559609,
0.0028109201,
0.009071531,
-0.03163812,
-0.0054171695,
-0.00081579405,
-0.0018932034,
-0.015594582,
-0.0073615406,
-0.0027085848,
-0.0060806987,
-0.015238059,
-0.019635176,
0.0072228927,
0.006707915,
-0.05342564,
-0.024507659,
-0.0049186978,
0.02981589,
0.025009431,
0.021114087,
0.003271429,
0.010121293,
0.031347618,
-0.010253339,
0.006559364,
-0.009111145,
-0.032932166,
-0.0062160455,
0.000232524,
-0.007579416,
-0.017694106,
-0.008695201,
-0.0070248246,
0.025498,
-0.019225836,
0.0312948,
0.010755111,
-0.025946954,
0.014049649,
0.017786538,
0.024071908,
-0.0041099186,
-0.027227797,
0.0042749755,
-0.029393345,
0.003964668,
-0.028838754,
-0.0017925187,
-0.015845468,
-0.009672338,
0.01987286,
-0.011204067,
-0.008001962,
0.016320832,
-0.00996944,
-0.003908549,
-0.01164642,
0.010913567,
0.03221912,
-0.020836791,
0.025880933,
-0.01610956,
-0.008160416,
-0.0070512337,
-0.0124584995,
0.018750472,
0.007203086,
-0.019159812,
0.00504084,
0.013462046,
-0.01865804,
-0.017337583,
0.00339027,
-0.012154795,
0.06063533,
0.0142081035,
-0.01909379,
-0.017020674,
-0.015832264,
-0.0064801364,
0.005885931,
-0.002573238,
-0.021681882,
-0.013944012,
0.012115181,
-0.0020929223,
-0.008946087,
-0.002332255,
-0.03243039,
-0.005975062,
0.007790689,
0.011884102,
0.010999396,
-0.003383668,
0.006872972,
-0.022579793,
-0.029419754,
-0.0065098465,
-0.027993662,
-0.016532106,
-0.0004017074,
0.047774088,
0.022619406,
0.01321116,
0.011785068,
0.022447748,
-0.0014937655,
0.007559609,
-0.007731268,
-0.012511318,
0.005658153,
-0.022672225,
0.032087073,
0.012729193,
-0.007064438,
0.0053610504,
-0.000025815942,
0.014987173,
-0.012960273,
0.0028356786,
-0.037791442,
0.011322908,
-0.05284464,
-0.00993643,
0.016941447,
0.0007930987,
-0.01356108,
-0.031189164,
-0.003383668,
-0.016360447,
0.011903908,
0.008450917,
0.0014764345,
0.03792349,
0.005691164,
0.019489927,
-0.019199425,
0.0033473552,
-0.013197955,
-0.012240625,
-0.024296386,
-0.00814061,
0.0042518675,
-0.014749491,
0.00029545196,
0.018090244,
-0.0022414736,
-0.015304082,
0.010735305,
-0.019621972,
-0.032720894,
-0.00006143214,
-0.023688976,
0.0015300781,
-0.008615973,
-0.031030709,
-0.04888327,
0.0054336754,
0.0011743803,
-0.014934354,
0.013508262,
-0.010603259,
-0.008569757,
0.04589904,
0.0062292498,
0.013983626,
0.003769901,
0.025867729,
0.017720517,
-0.0045093563,
-0.02717498,
-0.01179167,
0.00686637,
-0.0061665284,
0.043442994,
0.014340149,
0.000023340086,
-0.02610541,
-0.013679922,
0.0005933798,
-0.016492492,
-0.050335772,
0.01993888,
0.008807439,
-0.016650947,
-0.021668678,
-0.0005310708,
-0.011256885,
0.027491888,
-0.0123132495,
-0.007797291,
-0.00067219447,
-0.008015166,
-0.025392363,
0.00999585,
0.009725156,
0.027808798,
-0.0063546933,
-0.026409114,
-0.0015432826,
0.0073879496,
0.018182674,
-0.017284766,
-0.003349006,
0.02059911,
-0.0020566098,
0.010028861,
0.00967894,
0.018288312,
-0.003068409,
-0.03430544,
-0.0025435279,
0.040141854,
-0.0062919715,
0.0011842838,
0.0007472954,
-0.0010852496,
-0.0019740814,
-0.011461556,
0.0021358372,
-0.010788123,
-0.009652532,
-0.011131442,
0.02865389,
0.018182674,
0.0037038783,
-0.013131932,
0.0024378914,
0.0009664085,
-0.029287709,
-0.011309703,
0.004921999,
-0.034411076,
-0.016624538,
-0.0007052059,
0.010491021,
0.012451897,
-0.00588263,
0.018974949,
-0.014326945,
0.04508036,
-0.023834227,
0.021959178,
0.009467668,
0.0045588734,
-0.012154795,
0.007797291,
-0.034490302,
-0.027597524,
0.020506678,
-0.010590055,
-0.019159812,
0.029921526,
0.017575266,
0.028548254,
0.020414246,
-0.016703766,
0.027597524,
-0.019806836,
0.012656569,
-0.017522447,
0.006853165,
0.0056053344,
-0.028204935,
0.008992303,
0.021259338,
-0.05345205,
-0.027650343,
0.03132121,
-0.016598128,
-0.0038755375,
-0.026739229,
-0.02494341,
-0.03459594,
0.0047767484,
0.00046463535,
-0.0074209613,
0.010022259,
-0.0021638968,
-0.005786897,
-0.007975552,
0.009830792,
-0.032588847,
-0.013495058,
0.012610353,
0.024983022,
-0.0045060553,
-0.01845997,
-0.00660558,
0.010048668,
-0.017562062,
-0.020665132,
-0.00031959155,
-0.02164227,
0.044367313,
0.0061038067,
-0.005932147,
0.009414849,
-0.007658643,
-0.043575037,
-0.005975062,
-0.0035025089,
0.0123594655,
0.017165925,
0.0065098465,
-0.014234513,
-0.0027977156,
0.0045456686,
0.010312759,
-0.011421942,
-0.011402135,
0.028178526,
-0.00993643,
0.03309062,
0.009672338,
-0.022553384,
0.00350581,
0.04349581,
-0.004047197,
-0.001327058,
0.010893759,
0.009461065,
0.02772957,
-0.00014710701,
-0.0016563466,
-0.0043178904,
0.023517316,
0.01952954,
-0.014445785,
-0.014868331,
-0.0104183955,
-0.015885083,
-0.034965668,
0.0269505,
-0.0002673923,
0.0014846874,
0.017390402,
-0.0031789972,
-0.015119218,
0.01657172,
0.000053798256,
0.031189164,
0.006879574,
-0.0011372425,
0.01923904,
0.012187806,
-0.0257885,
-0.009797782,
-0.0010365577,
-0.002396627,
0.0045918846,
-0.0077114613,
0.0018866011,
-0.0027349938,
-0.0011281644,
0.01923904,
-0.022117633,
-0.009064929,
-0.0021242832,
0.0044466346,
-0.028521843,
0.009441258,
0.0014706575,
0.0073747453,
0.005635045,
0.007698257,
-0.038108353,
0.0003393984,
0.018143062,
0.0053478456,
-0.0027779087,
0.013759148,
-0.004826266,
-0.024811363,
-0.014511809,
-0.029631026,
0.014881536,
-0.003961367,
-0.022566589,
0.19320908,
-0.024732135,
0.00032433693,
0.025220705,
-0.0120227495,
-0.016466083,
0.005740681,
-0.009500679,
0.0032697786,
-0.004093413,
0.017548857,
0.032271937,
-0.02059911,
-0.008312269,
0.031796575,
0.0007477081,
-0.016096355,
0.0004378136,
-0.012729193,
0.0042914813,
0.0075530065,
-0.010292952,
0.013547876,
-0.00834528,
0.0304233,
0.0062886705,
-0.020018108,
-0.011785068,
-0.02129895,
0.020348223,
-0.0298423,
0.008840451,
-0.003839225,
0.01671697,
0.0109531805,
0.01576624,
0.0038458272,
0.003987776,
0.015475741,
0.013389421,
0.0018502886,
0.0008153814,
0.035652306,
-0.0042089527,
0.0060113748,
-0.009296008,
0.0022810872,
-0.02712216,
-0.0142081035,
0.01020052,
-0.043812722,
0.009751566,
0.006024579,
0.015330491,
-0.016466083,
-0.006704614,
-0.010761715,
0.028284162,
0.030502528,
0.023556931,
-0.024045499,
0.009395042,
-0.03636535,
0.016598128,
-0.011963329,
0.02489059,
-0.015568173,
0.008246246,
0.044631403,
-0.022909908,
0.0018222289,
-0.015462536,
-0.015858673,
-0.022936316,
-0.023306044,
0.0063745,
0.044604994,
-0.011408738,
0.024441635,
0.010675885,
0.0075530065,
-0.008338678,
-0.05456123,
0.0020219479,
-0.0046314984,
-0.007856712,
0.017231947,
-0.007836904,
-0.007539802,
-0.013970422,
0.004103316,
-0.00675083,
-0.009130951,
-0.01289425,
-0.0079425415,
0.016347243,
0.015541764,
0.016320832,
0.003928356,
-0.025365954,
-0.024837771,
0.05046782,
0.03486003,
0.020189768,
-0.01688863,
0.009084735,
-0.0044202255,
0.016452879,
0.013944012,
-0.030317664,
0.0194107,
-0.016703766,
0.008932883,
-0.022725044,
-0.00979118,
0.024335999,
0.0063348864,
-0.029446162,
0.05519505,
-0.02576209,
-0.0013196304,
-0.009223383,
0.0009045122,
-0.0021028258,
-0.01132951,
0.012148193,
-0.005955255,
0.021378178,
-0.004743737,
-0.04476345,
0.013534672,
0.020876406,
-0.0202822,
-0.011375726,
-0.004073606,
-0.03229835,
0.02045386,
-0.0038491285,
-0.013785558,
0.00324502,
-0.023081565,
-0.0016885328,
0.016215196,
0.047615632,
-0.0041759415,
0.012577341,
0.0104316,
0.018327925,
-0.00010414063,
0.0012717639,
0.019555949,
-0.00073078973,
0.014551423,
-0.03153248,
0.0129932845,
-0.042861994,
-0.035942804,
-0.03198144,
-0.009500679,
-0.005849619,
-0.049966045,
0.02222327,
0.018235493,
-0.021827133,
-0.0101411,
-0.004080208,
-0.16500415,
0.009903418,
-0.010088282,
-0.0013790509,
0.0137723535,
0.027544707,
0.008979099,
0.026607184,
0.0046546063,
-0.007057836,
0.015845468,
-0.0068597677,
-0.023504112,
-0.029155662,
-0.008246246,
0.009441258,
-0.0030849148,
0.023490908,
0.0059618577,
-0.005545914,
0.0012379272,
-0.038900625,
0.007731268,
-0.031030709,
0.00095815567,
0.00018909339,
0.013237569,
-0.013303592,
-0.0098373955,
-0.011421942,
0.004756942,
-0.0047074244,
0.018261902,
-0.015885083,
0.011580396,
0.00947427,
-0.0034926054,
0.015739832,
0.00011801573,
0.028838754,
0.019463517,
0.029287709,
0.026778841,
-0.0012841432,
0.019978495,
-0.016822606,
0.013112125,
-0.013904399,
0.014617445,
-0.014564627,
0.010675885,
-0.02210443,
-0.009190372,
0.048777636,
0.0312948,
0.014102467,
0.0013542924,
0.030634573,
-0.020229382,
0.014036444,
-0.0005001226,
-0.024798159,
0.042175356,
-0.0061533237,
0.0094940765,
-0.006899381,
-0.0073615406,
-0.00961952,
-0.022170452,
0.014472195,
0.007513393,
0.0071832794,
0.015568173,
-0.01819588,
-0.0033688126,
0.02802007,
-0.0056317435,
0.021272542,
-0.011322908,
-0.010378782,
-0.0071964837,
0.011653022,
-0.011375726,
-0.025656454,
0.002822474,
-0.016122764,
0.011177658,
0.010504225,
0.0005397363,
0.016360447,
0.0028703406,
-0.022751452,
0.020625519,
-0.009190372,
0.030608164,
0.007863314,
0.007018222,
-0.018790085,
0.014076058,
0.0018519391,
-0.00054138683,
0.0002995784,
0.007038029,
0.011593602,
0.02952539,
0.017403606,
0.0020268995,
0.0029792783,
0.01671697,
-0.015409718,
-0.0014483748,
-0.010259941,
0.0074935863,
0.03338112,
-0.01162001,
0.017918585,
0.012293443,
-0.0001799121,
0.0072096884,
-0.0020698144,
0.044314492,
-0.012841432,
-0.0007745298,
0.0010151004,
0.0043244925,
-0.023847431,
-0.14260922,
-0.016149174,
0.011507772,
0.030793028,
-0.018935336,
0.0049913228,
-0.0029363635,
0.024705727,
-0.012042556,
0.019661585,
-0.016083151,
-0.003961367,
0.015092809,
-0.0064966423,
-0.006991813,
0.000099704725,
-0.00068704964,
-0.015145627,
-0.05284464,
0.021497019,
0.020506678,
0.023570135,
-0.010649475,
-0.0010472864,
0.0073417337,
0.00075926207,
-0.016492492,
0.032958575,
0.020335019,
0.011065419,
0.008695201,
-0.005717573,
0.017720517,
-0.009797782,
-0.0040670037,
-0.009711952,
-0.009599713,
-0.031506073,
0.011283294,
-0.021695087,
0.0044631404,
-0.0011669528,
0.016928243,
-0.008219837,
-0.0074539725,
0.0010225279,
-0.008246246,
-0.004935203,
-0.0021143798,
-0.0046513053,
-0.024085112,
-0.012280238,
-0.032905757,
-0.034437485,
0.008899871,
-0.013811967,
-0.025498,
0.012451897,
-0.007685052,
-0.019595563,
-0.0036345543,
0.016096355,
-0.00611371,
-0.006985211,
0.016149174,
-0.01385158,
-0.008926281,
-0.029657437,
0.029419754,
-0.02071795,
0.0030964687,
0.0059387498,
0.0053379424,
-0.0007522471,
-0.025207499,
0.00055789255,
-0.01770731,
-0.020255791,
0.0123132495,
-0.021219723,
-0.012643363,
-0.016849015,
0.007038029,
-0.020044519,
0.017958198,
0.0038326227,
0.015449332,
0.0005616063,
0.033196256,
-0.0092035765,
0.011468158,
0.009883611,
0.000039691044,
0.018724062,
-0.007902928,
-0.0032895852,
-0.02833698,
0.013930808,
-0.011342715,
0.02324002,
-0.050309364,
-0.010781521,
-0.049147364,
0.011666226,
-0.0066253864,
-0.0099826455,
0.04212254,
-0.0065098465,
-0.009916622,
-0.00993643,
0.0032813326,
0.018209085,
-0.038029123,
0.0054567833,
0.009540292,
-0.013462046,
-0.03190221,
-0.002036803,
0.030000754,
-0.006678205,
0.01741681,
0.01700747,
-0.010187316,
-0.015000377,
0.007321927,
0.038927034,
-0.018525993,
0.00402739,
-0.012491511,
0.015779447,
0.0012569088,
0.021193314,
0.0060972045,
-0.02770316,
0.0060575907,
0.002558383,
-0.014894741,
-0.015013582,
-0.008404701,
-0.0037236852,
0.01141534,
0.030159209,
-0.018090244,
-0.05434996,
-0.0013724486,
0.012643363,
-0.000045313296,
-0.011719044,
-0.015739832,
0.012101977,
0.011903908,
-0.026567569,
0.029419754,
0.022751452,
-0.0074539725,
-0.02294952,
-0.02489059,
0.020202972,
0.0120227495,
0.0052917264,
-0.00402739,
-0.04267713,
0.026263865,
0.0115341805,
0.014643854,
-0.0024956614,
0.008206632,
0.0042485665,
-0.02862748,
0.011197465,
0.00080135156,
-0.008457519,
-0.013745944,
0.027029729,
0.0052158,
0.02207802,
-0.0033011392,
-0.0046777143,
-0.026211046,
-0.011672828,
-0.019714404,
0.0011520976,
-0.0061731306,
0.011177658,
-0.023160793,
-0.0041528335,
0.030977892,
0.0010514129,
-0.00010398589,
0.032245528,
-0.0015375057,
-0.008021768,
0.006163227,
0.009414849,
0.0009779625,
-0.006133517,
0.0018965045,
0.032615256,
-0.018988153,
-0.0041990494,
0.009170565,
-0.011897306,
-0.017733721,
0.017099902,
-0.0055789254,
-0.02506225,
0.0006140119,
0.030185618,
-0.017733721,
-0.034516715,
0.005836414,
-0.0033457046,
0.009956236,
-0.006559364,
0.0029693749,
-0.0026788746,
-0.014326945,
0.012643363,
0.0055492152,
-0.019437108,
-0.008688599,
-0.0071964837,
0.03607485,
0.011771862,
0.015673809,
-0.0028059685,
0.006655097,
0.022962725,
0.012947069,
-0.0062820683,
0.019595563,
-0.035124123,
0.020982042,
-0.025035841,
-0.010279748,
-0.0031756961,
0.004882385,
-0.008741417,
0.017258357,
0.02399268,
-0.027940843,
0.07542443,
0.012260431,
-0.0049253,
-0.0012437042,
-0.0017380499,
0.03126839,
0.015092809,
0.005189391,
-0.0073285294,
-0.0060773976,
0.008992303,
0.0026260563,
0.004842771,
-0.011204067,
0.030555345,
-0.0038524296,
-0.013798762,
0.0091573605,
-0.018063834,
-0.026858069,
0.01222742,
-0.02772957,
0.0121679995,
0.00675083,
-0.011289896,
-0.0052686185,
0.025326341,
-0.0030832642,
0.015607786,
-0.032694485,
-0.01066268,
-0.0135742845,
-0.05073191,
-0.014617445,
0.0026557667,
0.01793179,
-0.013640308,
-0.0121679995,
0.0064768353,
-0.008582963,
-0.010946578,
0.005542613,
0.00006132898,
-0.008688599,
-0.0021589452,
0.014366559,
-0.0020797178,
0.0014846874,
0.004070305
] |
The persistence of naive and memory T cells has long been of interest to immunologists, but the factors that influence the survival and homeostasis of these subsets have remained obscure. In recent years, it has become evident that the homeostasis of both naive and memory T-cell pools is highly dynamic and tightly regulated by internal stimuli, including cytokines and self-peptide–MHC ligands for the T-cell receptor. These homeostatic mechanisms might have a vital influence on the capacity of the T-cell pool to respond to both foreign and self-antigens. | [
-0.01668251,
0.006328877,
0.0002488535,
-0.018300368,
-0.011875347,
0.016404025,
-0.005645929,
0.005606145,
-0.023790479,
-0.026204005,
0.011888608,
-0.0046181907,
-0.001889712,
0.003333518,
0.0020554762,
-0.013791582,
0.040472988,
0.0059675113,
-0.015475746,
-0.0026522272,
-0.027092502,
0.015184001,
-0.008626369,
-0.013002544,
0.008148968,
-0.00863963,
0.015250307,
-0.037953373,
0.0027301365,
-0.019321475,
0.012153831,
0.00009971753,
-0.023286555,
-0.002633993,
-0.0063355076,
-0.015263568,
0.0012954472,
-0.017027298,
0.020992378,
0.0089910505,
0.02332634,
0.028750144,
-0.0027848387,
0.009912699,
0.014640294,
0.00840756,
-0.0017885957,
-0.009673999,
-0.011915131,
0.019308215,
0.03827164,
-0.0042999233,
-0.029386677,
0.005635983,
-0.02474528,
-0.016311197,
-0.0021731686,
0.019096036,
0.007214058,
-0.04484916,
0.0014413197,
0.008042879,
0.0045949835,
0.0075654783,
-0.00014235,
0.020952595,
-0.00081514544,
0.010104986,
0.005861422,
0.012757213,
0.009415407,
0.023167204,
-0.007950051,
0.009819872,
0.014083327,
-0.011132724,
-0.013619186,
0.009010942,
-0.009707152,
0.016722294,
0.0015374629,
-0.026111176,
-0.009395515,
0.03628247,
0.002638966,
0.007910267,
0.008672783,
-0.0016924525,
0.014295504,
-0.0012788709,
0.029678423,
0.0045121014,
0.026296834,
0.019984532,
0.0038026308,
-0.00056318386,
0.004601614,
0.012677646,
-0.017915795,
-0.015674664,
-0.033046752,
0.027503597,
-0.013433531,
-0.023644606,
-0.0354868,
-0.008009726,
0.0006386066,
-0.013009175,
0.028723622,
0.007976573,
-0.006723396,
0.025395075,
0.0007886232,
-0.047687046,
0.0020720526,
0.015091173,
0.0024383913,
-0.0038125766,
-0.016470332,
-0.002972152,
0.0061664283,
0.01879103,
0.014030282,
-0.020289538,
0.027264897,
0.009024203,
0.001259808,
-0.02018345,
-0.021310646,
-0.0046778657,
-0.00601061,
0.029731467,
-0.020899551,
0.008334624,
-0.01143773,
0.001379987,
-0.0019427565,
-0.005357499,
-0.0120477425,
0.0019626482,
0.013579403,
0.03630899,
-0.011179138,
0.0037031723,
0.013605925,
0.016297936,
0.013619186,
0.02684054,
-0.0140435435,
0.00793679,
-0.01832689,
-0.024546362,
-0.0073267776,
-0.0066703516,
0.005380706,
0.011537189,
-0.00035390657,
0.019745832,
-0.037290316,
-0.018512545,
0.012730691,
-0.0024964088,
0.025991827,
0.010071833,
0.0074063446,
0.020979118,
0.006663721,
0.025275726,
0.009130293,
0.004386121,
-0.002449995,
0.019387782,
0.0012473756,
0.012796996,
-0.019546915,
0.027158806,
0.0005345896,
0.0184595,
-0.022477625,
-0.023061115,
-0.0064382814,
0.01913582,
0.014215938,
0.005135375,
-0.013871148,
-0.010608909,
0.014215938,
-0.012273181,
-0.02113825,
0.014083327,
-0.0109802205,
-0.00034914084,
-0.0041838884,
-0.007797548,
-0.64247555,
-0.011683061,
0.035327666,
-0.011523928,
-0.007399714,
0.021071944,
0.011809042,
0.0068560075,
-0.026628362,
0.016510114,
-0.010701736,
0.016775338,
0.00053997687,
-0.01902973,
-0.03445243,
-0.038085982,
0.00080395635,
-0.024997242,
0.02032932,
-0.0068560075,
0.020793462,
0.0015565258,
-0.009349101,
0.032224562,
-0.01529009,
-0.012114048,
0.0051884195,
-0.017982101,
-0.008202013,
0.043602616,
-0.012617971,
0.003862306,
-0.010834348,
-0.008977789,
0.04331087,
0.02624379,
-0.015011606,
0.020727156,
-0.0119085,
0.026469227,
-0.016748816,
0.0002016107,
0.014852473,
0.0065874695,
-0.0048469454,
0.025872476,
-0.0084539745,
0.01529009,
0.01902973,
-0.018923642,
0.02975799,
0.003607029,
-0.015926624,
0.0022494202,
0.0097800875,
-0.0009738647,
0.017650573,
-0.026058132,
0.0047309105,
0.0079168985,
-0.00291745,
0.008944636,
-0.022212403,
-0.020727156,
-0.005861422,
0.009010942,
-0.0136457095,
0.004362914,
-0.007260472,
-0.006030502,
0.016377503,
0.012671015,
-0.017425133,
-0.002541165,
0.0022759426,
0.019281693,
0.0032390326,
-0.0037064876,
0.021390213,
0.0149453,
-0.0060271863,
-0.018419718,
0.002695326,
-0.0036136596,
0.013486575,
-0.01400376,
-0.004518732,
0.029837556,
-0.009494973,
0.022371536,
0.013201461,
0.019546915,
0.0077776564,
-0.04365566,
-0.027158806,
0.036229424,
-0.001652669,
-0.018565591,
0.013367225,
-0.028856233,
-0.00054702186,
-0.027556641,
0.028378831,
0.0020621067,
0.021668697,
0.005393967,
-0.027954474,
0.018857336,
0.049198814,
-0.01330092,
0.02019671,
0.009441929,
-0.0033799321,
-0.0047939005,
0.009488343,
-0.015250307,
0.036123335,
0.03466461,
0.008719197,
-0.021549346,
0.03837773,
0.012505251,
0.018830813,
-0.0065874695,
0.008513649,
0.019056253,
-0.0005913638,
-0.012001328,
0.01727926,
-0.019878443,
0.0056194062,
-0.0031229975,
0.01937452,
-0.019904966,
0.023366122,
0.0045784074,
0.029811034,
0.0092496425,
0.008314732,
-0.033683285,
-0.034956355,
-0.01739861,
-0.006358715,
-0.035911158,
-0.032277606,
-0.016523376,
-0.0144413775,
-0.015011606,
0.010807826,
-0.011537189,
0.021032162,
0.005486795,
-0.018181019,
0.011338271,
0.011000113,
-0.0068427464,
-0.009097139,
-0.0014181128,
0.0030848717,
-0.0008263345,
-0.0127107985,
0.0291745,
-0.00852028,
0.014918778,
-0.024015918,
-0.00087026204,
0.0021797991,
-0.0060968073,
0.019414304,
-0.06232734,
0.010814456,
-0.020965856,
-0.030049734,
0.0038026308,
0.0077312426,
0.0058183237,
-0.022371536,
-0.016390765,
-0.0041275285,
-0.01784949,
-0.000029319543,
-0.025302248,
-0.009415407,
-0.025129853,
0.042966083,
-0.018154494,
0.02930711,
0.0205415,
0.010370209,
0.04519395,
0.004518732,
0.01121229,
-0.03256935,
0.005974142,
-0.0035042553,
-0.035301145,
0.012240029,
-0.0057122344,
0.012419054,
0.029333632,
-0.002972152,
-0.011994697,
0.0046745506,
-0.02324677,
-0.00046413977,
-0.023525255,
-0.0097867185,
-0.0075787394,
0.012591449,
0.012942869,
0.0029008735,
-0.0076649366,
0.0067863865,
-0.0055729924,
0.0046347673,
0.012657754,
-0.0058249542,
-0.0010443145,
-0.0084539745,
-0.0058415304,
0.00910377,
-0.011152616,
0.0149718225,
-0.013937454,
0.0024516524,
-0.0016402368,
0.017610788,
0.014109849,
-0.009494973,
-0.01202122,
-0.015157479,
-0.018247323,
0.016470332,
0.0030268542,
0.016629465,
0.012783735,
0.010608909,
-0.02229197,
0.011126094,
-0.000044756336,
-0.0022444474,
0.00676981,
-0.008089293,
0.007883745,
-0.0013700412,
-0.007883745,
0.024678973,
0.00010930077,
-0.022252187,
0.003994917,
-0.014282243,
-0.00922975,
-0.007771026,
-0.007963312,
-0.015223784,
-0.011199029,
0.018751247,
-0.007883745,
0.041772578,
0.024692236,
0.014600511,
-0.0073267776,
0.0056094606,
-0.016297936,
0.007857223,
-0.010429883,
-0.006385237,
-0.021310646,
-0.017769922,
0.002398608,
-0.043523047,
-0.0032340595,
0.013353964,
-0.015104434,
0.016152063,
0.02520942,
0.017836228,
-0.009541388,
0.008679413,
0.00050185114,
-0.016669247,
-0.026482489,
0.014388333,
0.03092497,
-0.00671345,
-0.012127309,
-0.026760973,
-0.00026149303,
-0.012213507,
0.013294289,
0.0009158472,
-0.0014479503,
-0.009448559,
-0.019865181,
-0.009057356,
-0.0056823967,
0.021483041,
-0.010668584,
0.005858107,
-0.0064614885,
0.0060769157,
-0.0031843304,
-0.031428892,
0.008977789,
0.012226768,
0.010920546,
0.009620954,
-0.017146649,
-0.019188864,
-0.020209972,
0.006935574,
-0.023777217,
0.013857887,
-0.0078041786,
0.030739313,
0.005695658,
0.00022999782,
0.031561505,
0.012299703,
-0.018830813,
-0.00233396,
-0.0077312426,
-0.003389878,
-0.0020753678,
0.027848385,
0.0038821977,
-0.0063752914,
0.019666266,
-0.0059244125,
0.017093604,
-0.00829484,
-0.008924745,
0.028378831,
-0.011099571,
-0.019825399,
0.0033650133,
-0.009959113,
0.0075787394,
0.012823518,
0.013698754,
0.0073267776,
-0.009886177,
-0.007333408,
0.007963312,
0.011152616,
0.0041010063,
0.032648917,
0.017199693,
0.019546915,
0.009826502,
0.00723395,
0.008579955,
-0.0074859113,
-0.018366674,
0.004177258,
0.018260585,
-0.00089015375,
0.006013925,
-0.017915795,
-0.022756109,
-0.002667146,
0.018976687,
0.0063918675,
-0.007061555,
0.03827164,
0.009315948,
0.006398498,
-0.0148392115,
-0.0048867287,
-0.0011462595,
0.035778545,
0.031216715,
-0.010714998,
-0.00852691,
0.027158806,
-0.033311974,
-0.0011039895,
-0.012094156,
-0.0009456848,
0.006352084,
0.012545035,
-0.006395183,
0.0048469454,
-0.008951267,
-0.00069662405,
-0.020621067,
0.021217817,
0.0001694939,
-0.01668251,
-0.021841092,
-0.0052713016,
0.0046181907,
-0.020753678,
-0.031375848,
0.012690907,
-0.033205885,
-0.015489007,
0.0060537085,
0.003666704,
0.014149632,
0.018419718,
0.0070085106,
-0.014322027,
0.017690355,
-0.0052613555,
-0.0033103111,
-0.005662505,
-0.03317936,
-0.0011015031,
0.011583602,
0.0009150184,
-0.008115815,
0.010350317,
0.0023671128,
-0.009289426,
-0.0014114822,
-0.0044789487,
0.019241909,
-0.016655987,
0.014215938,
0.03126976,
0.028750144,
-0.008533541,
-0.002426788,
-0.008076032,
-0.030155823,
-0.033444587,
-0.0003319428,
-0.027503597,
-0.009727043,
-0.003278816,
-0.0054934258,
-0.0029837557,
-0.016364243,
0.013387117,
-0.020448672,
-0.007737873,
-0.005519948,
0.010376839,
0.016854905,
0.0036932265,
0.015223784,
-0.0033583827,
-0.015966408,
-0.023803739,
-0.046970945,
0.020130405,
0.0057122344,
-0.013579403,
-0.007432867,
0.0121472,
-0.008241796,
-0.016788598,
-0.010807826,
-0.009528127,
0.029094933,
0.014560727,
-0.012458838,
-0.0017388664,
-0.01458725,
0.0021847722,
0.021748263,
0.004923197,
-0.020475194,
-0.010403361,
0.011921762,
-0.0036335513,
-0.013174939,
0.025169637,
-0.027848385,
-0.0053840214,
0.012266551,
0.006836116,
0.017438393,
-0.0056392984,
0.008434082,
-0.012856672,
0.005533209,
-0.025262464,
-0.036865957,
0.005277932,
-0.006875899,
0.04832358,
0.028299265,
0.018167756,
-0.0072538415,
0.022318492,
0.013062219,
0.011543819,
0.0040413314,
-0.007134491,
0.037396405,
-0.008599847,
-0.008082663,
0.0066869278,
-0.013910932,
0.009853024,
-0.023299817,
0.015316612,
0.016085759,
-0.006935574,
-0.027317941,
-0.0028743513,
-0.030633224,
-0.019334737,
0.039703842,
-0.018432979,
0.01832689,
-0.01458725,
-0.0015573547,
-0.0018731355,
0.016112281,
-0.00086611795,
-0.004631452,
0.029731467,
-0.02414853,
-0.0005478507,
-0.015077911,
0.003477733,
-0.0015134271,
0.00094319833,
-0.012525143,
-0.0055033714,
0.020926073,
0.0025428229,
-0.016404025,
0.013831365,
0.019812137,
0.012525143,
0.003978341,
-0.022119574,
-0.023153944,
-0.024811586,
-0.00886507,
-0.032410216,
0.008513649,
-0.04071169,
0.008613108,
-0.010370209,
0.0070217717,
-0.012538404,
0.0038125766,
-0.02462593,
-0.027636208,
0.039889496,
-0.0116698,
0.019427564,
-0.019878443,
0.009753565,
0.011974806,
-0.018618636,
-0.014388333,
-0.018035145,
0.0073267776,
0.012916347,
0.047421824,
0.0076781977,
0.002620732,
-0.040472988,
0.0060172407,
0.007459389,
0.0032937347,
-0.02323351,
0.011596863,
0.0019062883,
0.0044391654,
-0.020634327,
-0.01810145,
-0.019109298,
0.017915795,
-0.01295613,
0.013440161,
-0.0019858552,
0.00020585842,
-0.0075455867,
0.024586147,
-0.0058813137,
-0.0109868515,
-0.012352748,
-0.012922977,
-0.00991933,
-0.027344463,
0.00049480615,
0.0020687373,
-0.0033418064,
0.019626481,
-0.0058382154,
-0.002574318,
0.02414853,
0.0021847722,
0.0025511112,
-0.001657642,
-0.004740856,
0.04028733,
-0.02428114,
0.008878331,
0.015449224,
-0.0018250638,
-0.0072538415,
-0.0291745,
-0.004004863,
-0.0101845525,
-0.004459057,
-0.0005868053,
0.017809706,
0.004034701,
-0.023790479,
-0.0012191957,
-0.017292522,
-0.006153167,
-0.034585044,
-0.012823518,
0.012286442,
-0.028670575,
0.0057155495,
-0.011179138,
0.013340703,
0.022955026,
0.005649244,
0.0052348333,
-0.016072497,
0.03827164,
-0.029784512,
0.02019671,
0.020833245,
0.0078041786,
-0.016178586,
0.0066206222,
-0.018234063,
-0.022451103,
0.0113846855,
-0.0046380823,
-0.032489784,
0.0009224778,
0.014083327,
0.029201021,
0.0027914692,
-0.008321363,
0.0064482274,
0.020209972,
0.018366674,
-0.003283789,
-0.021416735,
0.030474091,
-0.024758542,
-0.015833797,
0.010071833,
-0.026946628,
0.0028196492,
0.0054536425,
-0.0054569575,
0.0040413314,
-0.012094156,
0.002375401,
-0.026933368,
0.018393196,
-0.021907397,
-0.010058572,
-0.0048966743,
-0.0008043708,
-0.0043098694,
0.007306886,
0.010569125,
-0.019666266,
-0.01540944,
0.013347333,
0.020011054,
0.002922423,
-0.02392309,
0.0121472,
0.0032340595,
-0.022676542,
-0.017212955,
-0.001018621,
-0.011954914,
0.041268654,
0.0048071616,
0.004412643,
-0.0037628473,
0.02323351,
-0.04365566,
-0.017345566,
0.024758542,
0.014985084,
0.00437286,
0.025169637,
-0.015024867,
0.0074196057,
0.0018698202,
0.008162229,
0.005042547,
-0.021350428,
0.020342583,
-0.008599847,
0.023896568,
0.0132412445,
-0.021496302,
-0.02800752,
0.016019452,
-0.014149632,
-0.0010716656,
0.013552881,
-0.016960993,
0.00875235,
-0.012763844,
0.024453536,
-0.0060669696,
0.0129826525,
0.00852691,
-0.01506465,
0.010966959,
0.0075389557,
-0.019878443,
-0.0021134936,
-0.0035440386,
0.005460273,
0.018804291,
0.010211075,
-0.011000113,
-0.027556641,
0.015250307,
-0.01844624,
0.03190629,
0.024997242,
-0.014719861,
0.006567578,
-0.004286662,
-0.007903637,
-0.010237597,
0.002648912,
-0.012863302,
0.013440161,
-0.0022030063,
0.0036832807,
-0.005267986,
0.012326226,
0.010303902,
-0.03172064,
0.0061465367,
-0.0026223897,
-0.005675766,
-0.040897343,
0.008255057,
0.014772906,
-0.022013485,
0.012750583,
-0.011358163,
-0.008314732,
-0.018578852,
0.0065344246,
-0.036123335,
-0.00011261606,
-0.0060238712,
0.0030533767,
0.006640514,
0.005324346,
-0.014905517,
-0.0046181907,
-0.022543931,
0.006995249,
0.18512546,
-0.034585044,
-0.00250967,
0.009415407,
0.007923529,
0.004518732,
0.002320699,
-0.011537189,
0.0019162341,
-0.00034831202,
0.02064759,
-0.0018598743,
-0.003454526,
-0.0028909277,
0.011888608,
-0.012326226,
-0.035672456,
-0.0075124335,
-0.006255941,
-0.012684276,
-0.0040678536,
-0.008009726,
0.02975799,
0.006259256,
0.050816674,
-0.0013360594,
-0.008666152,
-0.0113846855,
-0.0065874695,
-0.0005449498,
-0.032993708,
0.01551553,
0.006779756,
0.0013708699,
-0.010648692,
0.0136457095,
-0.019626481,
-0.021337168,
0.029970167,
-0.0029671793,
-0.0101845525,
0.0034744176,
-0.00039949172,
0.009448559,
0.0037661626,
0.026522271,
-0.002935684,
-0.0036799652,
-0.0040811147,
0.0009937563,
-0.030314958,
-0.013347333,
0.0141761545,
0.005350868,
0.0018383249,
0.019931488,
0.01658968,
0.01551553,
-0.0062161577,
0.02416179,
-0.014600511,
-0.00874572,
-0.04129518,
0.033868942,
-0.0025759756,
0.022371536,
-0.029015366,
0.017226215,
0.005791801,
-0.017212955,
0.004909936,
0.0006431651,
-0.018777769,
-0.020263016,
-0.024785064,
-0.007306886,
0.02123108,
-0.0056227217,
-0.00624268,
0.0043496527,
0.008281579,
0.010675214,
-0.04272738,
0.0034280038,
0.016072497,
-0.008951267,
0.02474528,
-0.0062725176,
-0.040950388,
0.0022063216,
0.0129760215,
-0.0010219363,
-0.012942869,
-0.0037296945,
0.006627253,
-0.011470883,
0.003418058,
-0.0021764839,
-0.01680186,
-0.025991827,
-0.026416183,
0.068533555,
0.047315735,
0.01621837,
-0.006875899,
0.010032049,
-0.0024947512,
0.0059376736,
0.01178915,
-0.015130957,
0.01621837,
-0.032118473,
0.023419166,
-0.02146978,
-0.025156375,
0.013765059,
-0.016165325,
-0.020833245,
0.044265673,
-0.00980661,
-0.006968727,
-0.036865957,
-0.007797548,
0.026177483,
0.0144413775,
0.0036932265,
-0.03034148,
0.01621837,
0.0043927515,
-0.044159584,
0.029625379,
-0.017544484,
-0.009004312,
0.033868942,
0.011696322,
-0.017319044,
-0.00043803192,
-0.02031606,
-0.013108633,
0.026482489,
-0.0026555425,
-0.01786275,
0.01389767,
0.004038016,
0.016655987,
-0.005616091,
0.023167204,
0.032224562,
-0.009004312,
-0.011165877,
0.02064759,
-0.031667594,
-0.025235942,
-0.014507683,
0.017836228,
-0.019878443,
-0.010894023,
-0.016364243,
-0.007724612,
0.0077643953,
-0.0350094,
0.022928504,
0.0149718225,
-0.0077643953,
-0.0016617861,
-0.005267986,
-0.16571115,
0.017822968,
0.0067598643,
-0.024891153,
0.03546028,
-0.013712015,
0.008327994,
0.0044259042,
-0.027636208,
0.017902534,
0.030394524,
0.012989283,
-0.027344463,
-0.028617531,
0.004038016,
-0.0033451216,
-0.007737873,
0.021164773,
0.013095372,
0.018247323,
0.025143115,
-0.018870596,
0.01763731,
-0.006749918,
0.0182208,
0.010774673,
0.002837883,
-0.0084539745,
-0.0063620303,
-0.009992266,
-0.00025092557,
-0.008692674,
0.03707814,
0.009992266,
0.017266,
0.011338271,
0.004047962,
-0.011424469,
0.008327994,
0.042886514,
0.046042666,
-0.0017803075,
0.0059343586,
0.020117143,
-0.014322027,
0.029147977,
-0.011981436,
-0.008361147,
0.010927176,
-0.015117696,
0.01705382,
-0.0053873365,
0.020236494,
-0.0032025643,
0.008042879,
-0.01902973,
0.007167644,
0.012803627,
0.015687924,
0.0037197487,
0.0010658638,
-0.0019394412,
0.031481937,
-0.00092413544,
-0.012299703,
-0.018074928,
0.0019178918,
0.017173171,
-0.008593217,
0.013121895,
-0.02137695,
0.0084473435,
0.028458398,
0.0116698,
0.020263016,
0.020501716,
0.0061100684,
-0.013393748,
-0.005463588,
0.011252074,
-0.012312965,
0.013513098,
-0.038695995,
-0.006895791,
-0.008109185,
0.016284674,
0.026349878,
0.021350428,
-0.012677646,
0.0018449556,
-0.0036766499,
-0.03256935,
0.006398498,
-0.0038490447,
0.00618632,
0.027980996,
0.00043554543,
-0.014958561,
-0.008566694,
-0.00076458737,
-0.003994917,
-0.012319596,
-0.0121869845,
0.0026638308,
0.00029775396,
-0.0027533434,
-0.011941653,
-0.0054238047,
0.016496854,
-0.016669247,
0.004306554,
0.02697315,
0.007983204,
0.004502156,
-0.0057155495,
0.01973257,
-0.009415407,
-0.011901869,
0.0081887515,
-0.028060565,
0.07739199,
-0.002894243,
-0.011285227,
0.014481161,
-0.0032937347,
-0.023525255,
-0.1584971,
-0.03580507,
0.022172619,
-0.0036335513,
-0.017836228,
0.022384798,
-0.017557744,
-0.007134491,
-0.024639191,
0.009746935,
-0.021403473,
0.0045651463,
0.0054204892,
-0.035513323,
-0.005407228,
0.013015805,
0.017571006,
-0.010794565,
-0.022079792,
0.009415407,
0.014892256,
-0.022305232,
-0.029572334,
-0.010516081,
0.020382367,
-0.0029738098,
-0.019692788,
0.02790143,
0.019812137,
0.013725276,
-0.0048237382,
0.012153831,
0.028882755,
-0.025700081,
0.005536524,
0.010257489,
-0.0298906,
-0.009872916,
0.027370986,
-0.005732126,
-0.015542052,
0.017690355,
0.021045422,
-0.018804291,
0.0105890175,
-0.023883305,
-0.028803188,
0.0088518085,
0.02520942,
-0.02019671,
-0.009972374,
-0.027715774,
-0.038669474,
-0.020382367,
0.0034876787,
0.0057586483,
0.007598631,
0.034346342,
0.0054138587,
0.005337607,
0.020912811,
0.012876563,
-0.008878331,
-0.004820423,
0.050975807,
0.0051287445,
-0.015157479,
-0.03140237,
0.021668697,
-0.035168532,
0.0023389328,
-0.014693338,
-0.013360594,
-0.0034445801,
-0.010827717,
0.012743952,
-0.007989834,
-0.02649575,
-0.004939773,
-0.018234063,
-0.015210523,
-0.0060802307,
-0.011066418,
-0.011497405,
0.034028076,
0.0021284122,
0.0059210975,
-0.0014645268,
0.010814456,
0.0108476095,
-0.025235942,
0.0413217,
-0.0022096368,
-0.016536636,
0.017650573,
0.009136923,
0.0009730359,
-0.0020687373,
0.028458398,
0.021390213,
0.00022606093,
-0.0033302028,
-0.033232406,
0.01576749,
-0.028431876,
-0.00070076814,
0.012896455,
-0.012220137,
0.009939222,
-0.06232734,
0.017902534,
0.006057024,
-0.01995801,
0.0036103444,
-0.012564926,
0.007048294,
-0.03431982,
-0.01214057,
0.008951267,
-0.007824071,
0.0034047966,
0.033868942,
0.005287878,
-0.008918114,
0.004717649,
0.01109294,
-0.00875235,
0.009349101,
-0.008076032,
0.035301145,
-0.0014844184,
0.028962322,
0.019759092,
-0.036255945,
-0.004754117,
-0.00077370444,
-0.029147977,
-0.00026895243,
0.010171291,
0.021668697,
0.017252738,
0.043151736,
-0.042541724,
-0.030978015,
0.003547354,
-0.026628362,
-0.029625379,
0.0012680962,
-0.054264568,
0.0182208,
0.009435298,
-0.022557193,
0.05018014,
0.018486023,
0.019162342,
-0.036919,
-0.02251741,
0.028856233,
0.017226215,
-0.012518512,
-0.030182347,
-0.027636208,
-0.0048270538,
0.0015739311,
0.001310366,
0.0049662953,
0.019321475,
-0.017385349,
-0.03758206,
0.020992378,
0.0053541837,
0.00043098693,
-0.010191184,
0.028299265,
0.0044656876,
-0.0070681856,
0.027132284,
-0.003320257,
-0.017212955,
0.0055298936,
-0.018605374,
0.014932039,
0.0063885525,
-0.0020703948,
-0.011252074,
0.0041142674,
0.06243343,
0.017796444,
-0.015502268,
0.031932816,
0.0112454435,
-0.021735001,
-0.00723395,
0.010907285,
0.004233618,
0.011331641,
0.02288872,
0.016549898,
-0.011828934,
0.021761524,
-0.0014139686,
0.04795227,
-0.0017438394,
-0.0071543828,
0.0074262363,
-0.027012935,
-0.004432535,
0.014295504,
-0.03898774,
-0.034585044,
-0.009050725,
0.010350317,
-0.005334292,
0.0026041556,
0.0062758327,
-0.001199304,
-0.030261913,
0.011039896,
-0.0148392115,
0.020607805,
-0.011059787,
0.024678973,
0.025633777,
0.005533209,
-0.01949387,
-0.010237597,
0.0072206887,
-0.0076384144,
0.011517297,
-0.017212955,
0.021642175,
0.009143554,
0.032118473,
-0.0006518677,
-0.030235391,
-0.015661402,
-0.008606478,
-0.027052717,
0.010264119,
0.030845402,
-0.028909277,
0.06142558,
0.006139906,
-0.018897118,
0.00922975,
-0.016536636,
0.018711463,
0.0053972825,
0.015979668,
-0.007035033,
-0.0038589905,
0.045618307,
-0.0020422149,
0.027821863,
-0.048641846,
0.011450991,
0.02556747,
-0.019944748,
0.016138803,
0.011974806,
-0.0061465367,
0.002643939,
-0.0073798224,
0.0024466796,
-0.0012092498,
-0.025965305,
-0.0058547915,
0.022265447,
-0.027530119,
0.0046911268,
-0.035592888,
-0.005297824,
0.0018863967,
-0.055484593,
-0.0049563497,
0.0072538415,
-0.007903637,
-0.022013485,
-0.014017021,
-0.009892807,
0.017226215,
-0.008725828,
0.03628247,
-0.017027298,
-0.030208869,
-0.0032158254,
-0.015740968,
-0.023034593,
-0.009594432,
-0.011192399
] |
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here we show that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns. Moreover, we demonstrate that cellular origin influences the in vitro differentiation potentials of iPSCs into embryoid bodies and different hematopoietic cell types. Notably, continuous passaging of iPSCs largely attenuates these differences | [
-0.021976983,
-0.008689181,
0.0036541459,
-0.03327162,
-0.021364704,
-0.0015176756,
-0.011509582,
0.010200343,
-0.019202178,
-0.02094783,
-0.0029376466,
-0.0006912589,
-0.0017879911,
0.003722539,
-0.022836784,
0.01924126,
0.030614056,
-0.00083944394,
-0.009034404,
0.034808833,
-0.024921145,
0.024608491,
-0.0010299676,
-0.00624657,
-0.027148806,
0.024009237,
0.0029197342,
-0.015906282,
-0.010037502,
-0.025806999,
0.008324418,
0.0004986997,
-0.013496239,
0.00057971297,
-0.022458993,
-0.0076274597,
-0.013001204,
-0.026080571,
0.015828118,
0.00654294,
0.014460256,
0.008272309,
-0.026445333,
0.010740974,
-0.0009265637,
-0.0027568934,
-0.01511162,
-0.006458263,
-0.0025859107,
0.03327162,
0.03400114,
-0.01971024,
-0.00025281022,
0.011809209,
-0.021143239,
-0.016896354,
0.003790932,
0.00866964,
0.0063703293,
-0.0041589523,
-0.00018899702,
0.008871563,
-0.015880227,
0.0015657136,
-0.014186684,
0.0073799416,
-0.0012766713,
-0.0056440593,
0.014290902,
-0.0059436862,
0.035460196,
-0.005969741,
-0.012740659,
-0.011503069,
0.02204212,
-0.005513787,
-0.028764185,
-0.023826854,
-0.0028725103,
0.0085784495,
-0.0035857528,
-0.026757987,
0.0010926613,
0.029988747,
0.004494404,
0.015267946,
0.00947733,
0.023839882,
0.021898821,
0.008448177,
0.027956495,
0.039081775,
0.009301462,
-0.0028578546,
-0.0018417286,
-0.008708722,
0.0017081992,
0.018186051,
0.00426317,
-0.03264631,
-0.007842409,
0.028555749,
-0.00043600603,
-0.025481317,
-0.042807568,
0.007425537,
0.025507372,
-0.005093658,
0.022198448,
-0.011424906,
-0.01952786,
0.007959655,
0.009509899,
-0.03368849,
0.024478218,
0.007236642,
0.0018580126,
0.01663581,
-0.03358427,
-0.0011423277,
0.023071274,
0.032932907,
0.011209955,
-0.025142608,
0.019775378,
0.016661864,
-0.020439768,
-0.0022732564,
0.0038723524,
-0.0000708866,
0.01511162,
-0.03131753,
-0.006728579,
0.02541618,
-0.025846079,
-0.008343958,
-0.008493772,
-0.0029930125,
-0.014095493,
-0.025194718,
-0.018459624,
0.006585279,
-0.004930817,
0.0011472129,
-0.0061846906,
0.015463355,
0.028633913,
-0.005832955,
0.02803466,
0.009601089,
0.01130766,
-0.004517202,
0.027904386,
0.0002922991,
-0.010662811,
0.010395752,
0.022302665,
0.018993743,
-0.014564474,
0.0105911605,
-0.0053639733,
-0.015528492,
0.0062335427,
0.016687917,
-0.0012245623,
0.023123384,
0.009868148,
0.010675838,
0.0155936275,
-0.013613485,
-0.023032192,
0.015945364,
-0.028347313,
0.00748416,
0.0008508428,
0.0021136727,
-0.005227187,
0.00755581,
-0.042963896,
-0.024048317,
-0.00624657,
0.024387026,
0.024452163,
0.000118466625,
-0.0051197126,
0.0011610544,
0.020583067,
-0.02489509,
-0.0039081774,
-0.018498706,
-0.018368434,
-0.0017586799,
0.00057645614,
-0.013352939,
-0.64073265,
-0.042963896,
0.02493417,
-0.025728835,
0.028529694,
0.032880798,
0.006774174,
-0.01705268,
-0.0143560385,
0.022680456,
-0.012245622,
0.014772911,
0.017808262,
-0.020075005,
-0.013743757,
-0.025207745,
-0.008754318,
-0.019501805,
0.011301146,
0.008050845,
-0.01904585,
-0.011594259,
-0.00902789,
0.023983182,
-0.0008370013,
0.0143560385,
0.02094783,
-0.007738191,
-0.02489509,
0.04257308,
-0.017222036,
0.014798965,
-0.00016019456,
-0.01496832,
0.044214513,
0.012538736,
-0.0099332845,
0.032099165,
0.020374632,
0.037752993,
-0.0058362116,
0.0002458895,
0.017182954,
0.016857272,
-0.012382409,
0.021065077,
-0.0035434142,
0.00037005555,
0.0058590095,
0.00079384854,
0.0045074313,
0.011398851,
-0.03069222,
0.0024002723,
0.01021337,
-0.0036574027,
0.0045041745,
-0.0051685646,
0.012408463,
0.000114293834,
0.0162971,
0.018642006,
-0.029806366,
-0.011437932,
0.014147602,
0.02604149,
0.0038495548,
-0.03035351,
0.002486578,
-0.03178651,
0.0082006585,
0.042025935,
-0.017938534,
0.002175552,
-0.0010625357,
0.022563212,
0.0040873024,
-0.0035173597,
-0.0023139666,
-0.0048200856,
0.0035075892,
0.0022325462,
-0.0019964273,
0.015932336,
0.01676608,
0.012434518,
-0.022823757,
0.017508635,
-0.014343011,
0.0120437,
0.006865365,
0.0021983497,
0.024569409,
-0.06544895,
-0.033896927,
0.008487258,
-0.017143872,
0.0119264545,
-0.0013979876,
-0.028008604,
-0.0068783923,
-0.004741922,
0.017235063,
0.006937015,
0.018902551,
0.009060458,
-0.019788405,
-0.003846298,
0.027904386,
-0.044214513,
0.02227661,
-0.010988492,
0.0065755085,
-0.01263644,
-0.0011561691,
-0.022146339,
0.0013817035,
-0.009718334,
-0.014825019,
-0.017756153,
0.009874661,
-0.010232911,
-0.010148234,
0.016205909,
0.016427372,
0.000050327963,
-0.017691016,
-0.009978879,
-0.0054193395,
0.001555129,
-0.004217575,
-0.0055854367,
0.008298364,
-0.036658704,
0.017886424,
-0.0048265993,
0.012512681,
-0.003595523,
0.015411247,
-0.01875925,
-0.025898188,
-0.005145767,
0.0056961686,
-0.018472651,
-0.016258018,
-0.010838679,
-0.012186999,
-0.011867832,
0.017365335,
-0.00829185,
-0.0085784495,
-0.0011928083,
0.0043641315,
-0.002810631,
0.015645737,
-0.008109468,
-0.006321477,
-0.02798255,
0.009021376,
-0.016544618,
-0.032516036,
0.037284013,
-0.00048770796,
0.014525393,
0.010324102,
-0.011105738,
-0.04137457,
-0.00022329534,
-0.0063670725,
-0.016844245,
0.011203442,
0.0024605233,
-0.004510688,
0.0066504152,
-0.01895466,
-0.004259913,
-0.004145925,
0.019254288,
-0.01681819,
-0.011535637,
-0.011535637,
-0.039889462,
0.0035857528,
-0.016192881,
0.036606595,
0.020322522,
0.028686022,
0.011346742,
0.008233227,
0.027617786,
0.0019801431,
0.017469553,
-0.010806111,
0.022029093,
0.016948463,
-0.015945364,
0.005090401,
0.0160105,
-0.0072887507,
0.021481948,
0.017378362,
-0.013209639,
-0.0007698295,
-0.02769595,
0.024621518,
-0.036893193,
-0.007458105,
-0.023188518,
-0.0033936007,
0.021416811,
0.013326885,
0.014929238,
-0.015762983,
-0.00705426,
-0.0059111184,
-0.014733829,
-0.0069891238,
-0.021911848,
0.00007414342,
0.001291327,
-0.006937015,
0.009321003,
0.0029848705,
0.007979196,
-0.011392337,
0.009588062,
0.0105911605,
0.014798965,
0.004676786,
-0.009835579,
0.0063442746,
0.010447861,
0.012506167,
-0.011099224,
0.021012967,
0.023449065,
0.011978564,
-0.024947198,
0.042025935,
-0.004947101,
0.011073169,
0.016648836,
0.00573525,
0.011249037,
-0.012147918,
-0.014212739,
0.029467657,
-0.013098908,
-0.015515464,
0.018928606,
-0.030092966,
0.009379625,
-0.018355407,
-0.00104788,
0.024530327,
-0.0074125095,
0.0017749639,
0.017730098,
0.006865365,
0.01577601,
-0.009783471,
-0.018120917,
0.0031558531,
-0.01624499,
-0.0009868147,
0.003370803,
0.005598464,
-0.01396522,
-0.03163018,
-0.0018938376,
-0.03368849,
0.0062367995,
0.023396956,
-0.009848607,
0.007777273,
0.0026298778,
0.016414344,
0.005761305,
0.021716438,
0.0052239303,
-0.010278506,
-0.02498628,
0.012642954,
0.015424273,
0.0014159001,
0.0057873596,
-0.026445333,
-0.028972622,
-0.0033642894,
-0.00044496226,
0.013164044,
-0.0018124173,
0.010864733,
-0.007490673,
-0.011711505,
-0.0095359525,
0.005686398,
-0.011001519,
0.034704614,
0.0076470003,
0.0035857528,
-0.027435405,
-0.018029725,
-0.0019182637,
0.034391962,
0.0123042455,
-0.0026119652,
-0.011998105,
-0.0013572774,
-0.018303297,
0.00059681124,
-0.018225133,
-0.0074320505,
0.011001519,
-0.0059371726,
-0.008213686,
0.005321635,
0.0022423167,
0.053620193,
-0.010864733,
-0.008806426,
-0.03426169,
-0.012076268,
-0.0114705,
0.015619682,
0.025833052,
-0.007301778,
0.00084107235,
0.008506799,
-0.0120046185,
0.0024181847,
-0.016271045,
0.015320055,
-0.022498075,
0.008702208,
0.0052369577,
0.008793399,
-0.020700313,
-0.009268894,
0.02665377,
-0.02370961,
-0.016414344,
-0.017117817,
-0.009353572,
-0.003203077,
0.007516728,
0.024269782,
0.02665377,
0.016492508,
0.0065071154,
0.019449696,
0.020973885,
-0.018251188,
-0.00075476675,
-0.028477585,
0.0059306594,
0.010669325,
0.0059827683,
-0.0064159245,
-0.033766653,
0.011600773,
0.0074320505,
-0.0042957384,
0.011060142,
0.01782129,
0.016609754,
0.012786253,
-0.015228865,
-0.0031884215,
0.0032535577,
-0.005390028,
-0.0074711326,
0.0054844758,
-0.011776641,
0.006917474,
-0.027904386,
-0.02042674,
-0.007321319,
-0.00056587154,
0.00874129,
0.0011903656,
-0.011099224,
0.0057450207,
-0.006301936,
-0.0011008033,
-0.02617176,
0.0023416495,
-0.00033931935,
-0.017508635,
-0.021872766,
0.0017570514,
-0.016505536,
-0.020504903,
0.008024791,
0.010395752,
-0.01277974,
-0.01705268,
0.0062595974,
0.0038886366,
0.030666165,
0.024321891,
-0.0119459955,
-0.010245939,
0.026354143,
0.005158794,
-0.032385763,
-0.0047158673,
-0.015684819,
-0.005093658,
0.015280973,
-0.00088015414,
-0.010526025,
0.003582496,
-0.00091027963,
0.02622387,
-0.013222666,
-0.015906282,
0.002810631,
-0.0052890666,
0.021625249,
0.034183525,
-0.0044520656,
-0.002634763,
-0.011405365,
-0.006813256,
-0.036841087,
-0.032750525,
-0.013151017,
-0.0027780628,
-0.0059795114,
-0.016609754,
0.00022146339,
-0.025833052,
-0.012642954,
0.0235142,
-0.013255235,
0.026249925,
0.0027796912,
0.0022976827,
0.022771647,
-0.014199711,
0.012812308,
0.01909796,
-0.01733928,
-0.0040221657,
-0.015150701,
0.0337406,
0.0015779266,
-0.040071845,
0.0023970155,
0.0032698417,
0.00075598806,
-0.032333653,
-0.007764246,
-0.010864733,
0.038300138,
-0.0059502,
-0.002835057,
-0.00926238,
-0.000091496135,
0.009093026,
0.018798333,
0.016166827,
-0.0139391655,
0.012245622,
0.011275092,
0.0072431555,
-0.010838679,
0.009229812,
-0.042833623,
-0.005390028,
0.026588634,
0.027279079,
0.0013637911,
0.0026738446,
0.030614056,
0.00039692427,
-0.015515464,
-0.013665593,
-0.025403153,
-0.004123127,
-0.028659968,
0.047054455,
0.051223177,
0.012721118,
0.013496239,
0.0311612,
0.01234984,
0.0028480843,
0.007809841,
0.0052955803,
0.019723268,
-0.017925506,
0.019853542,
-0.010024475,
-0.00029637013,
0.018186051,
-0.02062215,
0.004947101,
0.038847283,
-0.024504272,
-0.020166196,
0.02227661,
-0.03710163,
-0.04460533,
-0.0025875391,
0.0033805734,
0.013457158,
-0.029285276,
0.006334504,
-0.009412194,
-0.019671159,
-0.009412194,
0.0020257386,
0.032568146,
-0.011275092,
0.021221403,
-0.010688866,
0.0047777467,
-0.011196928,
0.0050154943,
-0.01049997,
-0.008689181,
0.009959338,
-0.009685766,
0.012512681,
0.01358743,
-0.021494975,
0.011724533,
0.025064444,
-0.028920513,
-0.0070347195,
-0.016479481,
-0.02793044,
-0.008624045,
-0.014877128,
-0.025820024,
-0.001791248,
-0.0066471584,
0.013365966,
-0.031343583,
0.0129425805,
-0.010493456,
-0.019436669,
0.020205276,
-0.02071334,
0.02042674,
-0.014603556,
0.018355407,
0.03900361,
0.0009770443,
-0.028190985,
-0.029519767,
-0.0027275821,
0.010030989,
0.039967626,
0.008070386,
-0.00017342537,
-0.0331674,
0.00866964,
0.00016619932,
-0.016140772,
-0.014343011,
-0.0075948914,
-0.021560112,
-0.012310759,
-0.0012856275,
0.01035667,
-0.02555948,
0.008702208,
-0.0040873024,
0.02651047,
0.00032649565,
0.0063312473,
-0.02627598,
0.031109093,
0.0073408596,
0.009926771,
0.01976235,
0.005575666,
-0.01710479,
-0.030848546,
-0.016544618,
0.009887689,
-0.006588536,
0.016375262,
-0.024686653,
0.0013214524,
0.018902551,
0.005044806,
0.0054453937,
0.0078033274,
0.009281921,
0.04090559,
-0.0029637013,
0.0032095907,
0.0040612477,
0.010467402,
0.012460573,
-0.017704044,
-0.008115982,
0.003406628,
-0.013756785,
-0.0034261688,
0.03900361,
-0.0005622076,
0.019071905,
0.0014207853,
-0.02722697,
-0.012499654,
-0.023501173,
-0.04158301,
0.004230602,
-0.02023133,
-0.0005430738,
0.016805163,
0.039602865,
0.021963958,
-0.0018091605,
0.010858219,
0.0076600276,
0.015762983,
-0.013144503,
0.038300138,
0.010193829,
0.01857687,
-0.027279079,
0.013092394,
-0.017886424,
-0.03040562,
-0.009040917,
-0.02428281,
-0.021872766,
-0.006360559,
0.0023888734,
0.025103526,
-0.0054714484,
-0.0039440026,
0.0047614626,
0.010337129,
0.01957997,
-0.005761305,
-0.016896354,
-0.011060142,
-0.017977616,
-0.0153330825,
-0.0052206735,
-0.010942897,
0.004670272,
-0.014811993,
-0.0046279333,
0.00045676823,
-0.014043384,
-0.018199079,
0.0047810036,
-0.0025289163,
-0.015880227,
-0.0058069,
-0.0032665848,
-0.013561375,
-0.008448177,
-0.012844876,
0.0122847045,
-0.016453426,
-0.033401888,
0.031239364,
0.007757732,
0.018459624,
-0.00931449,
0.00079466274,
-0.020700313,
-0.029780312,
-0.016205909,
0.03168229,
-0.011724533,
0.050571814,
0.013847975,
0.0132617485,
-0.038821228,
0.011802696,
-0.06597003,
-0.032620255,
0.017508635,
0.023188518,
0.009737875,
-0.002747123,
0.0020843612,
-0.012740659,
-0.008089927,
0.009177703,
-0.0015233749,
-0.037831157,
0.020452796,
-0.00023978297,
0.01035667,
0.006793715,
-0.026966425,
-0.034027196,
0.01843357,
-0.0014175285,
0.007073801,
0.018159997,
0.0011366282,
0.04979018,
-0.0070347195,
0.025390126,
0.02223753,
0.009145135,
0.024842981,
-0.027279079,
-0.01563271,
-0.00023571195,
-0.012760199,
-0.004217575,
0.011835264,
0.008298364,
0.0055854367,
-0.009490358,
-0.0036346049,
-0.024022264,
0.0012921412,
-0.010271993,
0.016844245,
-0.0046898127,
0.0016438771,
0.020270413,
0.022537157,
-0.0079205725,
-0.010096125,
0.012323786,
0.005227187,
-0.011652882,
0.0030614056,
-0.012414977,
-0.0019198922,
-0.005845982,
-0.017599825,
-0.019658132,
-0.010793083,
-0.010389239,
-0.026588634,
-0.0066764695,
0.016336182,
-0.015046483,
-0.021012967,
-0.013405048,
-0.009822552,
-0.008500285,
-0.037648775,
-0.0095554935,
-0.003934232,
-0.021833684,
0.005575666,
-0.0076470003,
-0.004953615,
-0.0038690956,
-0.0041003292,
0.0019964273,
0.01035667,
0.016231963,
0.18498707,
-0.013365966,
0.023032192,
0.01049997,
-0.00009933284,
-0.02688826,
0.0014248564,
0.007894518,
-0.011978564,
0.0085979905,
0.014473284,
0.0009786728,
-0.0017358821,
-0.0016039811,
0.03149991,
-0.028399423,
-0.0051197126,
0.0022406883,
-0.018029725,
-0.0077056233,
0.010271993,
-0.030040856,
0.029806366,
0.0018335866,
0.021976983,
0.010806111,
-0.022498075,
0.011183901,
0.027565679,
0.008897617,
-0.0120046185,
0.013913112,
-0.009418707,
0.008500285,
0.023032192,
-0.004881965,
0.0032779837,
-0.011581232,
0.0039537726,
-0.015749956,
-0.0021560113,
-0.0048265993,
-0.0017456525,
0.0085979905,
0.0016373635,
0.01520281,
-0.0021120443,
0.0075753503,
0.022341747,
-0.012890472,
-0.03710163,
0.0041328976,
-0.0020224818,
0.015606655,
0.007256183,
-0.009522925,
0.018329352,
0.02850364,
0.0026054515,
0.028321259,
-0.006956556,
0.008650099,
-0.016218936,
0.0248039,
-0.019540887,
0.0153330825,
0.0034457098,
-0.016218936,
0.011548664,
-0.01728717,
-0.01563271,
0.0055593825,
-0.011353255,
0.0051718215,
0.0006326362,
-0.028321259,
0.046767857,
0.0047288947,
0.011939482,
0.026132679,
0.017756153,
0.010656297,
-0.033037126,
0.02033555,
0.0062302863,
-0.03548625,
0.040775318,
0.012649467,
-0.029571876,
-0.021312594,
0.0079336,
-0.0044097267,
-0.006376843,
-0.015984446,
0.0106302425,
-0.009568521,
0.007809841,
0.0025614847,
-0.0063800993,
-0.011255551,
-0.029806366,
0.0894191,
0.011301146,
0.010460888,
-0.012538736,
0.02983242,
0.02019225,
-0.0047288947,
-0.0136395395,
0.011691964,
0.014408147,
-0.018668061,
0.005113199,
-0.014447229,
0.007692596,
0.028764185,
-0.0019785147,
-0.03621578,
0.05286461,
0.0041133566,
-0.009601089,
-0.0154373,
-0.0012905127,
0.0143169565,
0.0020729625,
-0.0011708247,
0.00800525,
0.016049583,
-0.022771647,
-0.009099539,
-0.012584331,
-0.008024791,
0.015854172,
0.01049997,
0.003650889,
-0.007673055,
0.0078033274,
-0.00610327,
-0.023084302,
0.010799597,
-0.018563842,
-0.008044331,
0.022745593,
0.012154432,
-0.0016243362,
-0.0054747052,
0.030275347,
0.023097329,
-0.0039505158,
-0.02593727,
-0.009744389,
-0.026210843,
-0.0064908313,
-0.0073082917,
0.025194718,
-0.006373586,
-0.00016029633,
-0.017599825,
-0.022393856,
0.0010788197,
-0.02774806,
0.027852278,
-0.02281073,
-0.010232911,
-0.00771865,
-0.014121547,
-0.16205908,
0.0021087874,
0.031239364,
-0.011867832,
0.025494345,
-0.0019166353,
0.009334031,
-0.024504272,
-0.0036834572,
-0.0049243034,
0.048252963,
0.008063872,
-0.043068115,
-0.015554546,
0.005718966,
0.013164044,
-0.01344413,
0.052994885,
0.0122651635,
0.0055593825,
0.035043325,
-0.009829066,
0.016687917,
0.004865681,
0.007992223,
-0.0034945619,
0.01705268,
-0.020739395,
-0.012799281,
-0.036815032,
-0.00999842,
-0.0027080413,
0.033427943,
0.0008052474,
0.0062563405,
0.0018238161,
-0.0067611467,
-0.014421174,
0.0011529123,
0.010193829,
0.02503839,
0.0027487513,
-0.010975465,
0.0026901287,
0.009685766,
0.024478218,
-0.025715807,
-0.00062327285,
0.016114717,
-0.0068588513,
0.011718019,
0.001611309,
-0.016075635,
0.0146165835,
0.018602924,
0.003738823,
0.031760454,
0.013190099,
0.008930185,
-0.003983084,
-0.0119264545,
-0.0010780056,
0.032359708,
-0.010258965,
0.009672739,
-0.022458993,
0.016753053,
0.011841778,
-0.026106624,
0.003110258,
-0.030822493,
0.0013165673,
0.0029099637,
-0.03022324,
0.03410536,
0.013196613,
-0.0059599704,
0.0006733464,
-0.011216469,
-0.009066972,
-0.03876912,
0.021820657,
-0.022354774,
-0.022003038,
-0.023175491,
0.018329352,
0.02199001,
0.011939482,
-0.016401317,
-0.011118765,
0.027044587,
-0.01938456,
-0.004474863,
-0.002455638,
0.011203442,
0.020361604,
-0.01999684,
-0.022445966,
-0.008832481,
0.0055398415,
0.03915994,
-0.011190414,
-0.007673055,
0.0073408596,
0.042885732,
-0.0047810036,
-0.026705878,
0.010063557,
0.06143655,
-0.017795235,
-0.021859739,
0.0027373526,
0.0015453584,
0.020908749,
0.0028252865,
0.04747133,
-0.0064615197,
0.0030809464,
0.009887689,
-0.04147879,
0.071754135,
-0.008174605,
0.012649467,
0.04418846,
-0.009978879,
-0.007093342,
-0.13381599,
-0.0133203715,
0.0013173815,
0.0047354084,
-0.0050317785,
0.02105205,
-0.0014598671,
0.022511102,
-0.00587855,
0.016231963,
-0.003274727,
-0.032620255,
0.013274776,
-0.010897301,
0.021442866,
-0.013365966,
-0.0009941426,
0.0011463987,
-0.022901919,
0.042260423,
0.01491621,
0.018746223,
-0.030822493,
-0.004686556,
0.017834317,
0.03282869,
-0.046324927,
0.022003038,
0.022393856,
0.033297673,
0.0058036433,
-0.015502437,
0.024191618,
0.001859641,
-0.0154373,
0.004911276,
0.0066243606,
-0.030145075,
0.03801354,
-0.011086197,
-0.0035010756,
0.006428952,
0.0049047624,
-0.0046409606,
0.00012996726,
-0.011463987,
-0.017404417,
-0.006520143,
0.014369066,
-0.01663581,
-0.03824803,
-0.032047056,
-0.014004302,
-0.00829185,
0.017495608,
-0.008897617,
0.0038039593,
0.010271993,
-0.0109103285,
-0.00067741744,
-0.011190414,
-0.01862898,
-0.018733196,
-0.020413714,
0.018355407,
-0.01872017,
-0.025194718,
-0.031812564,
0.019592997,
-0.021690384,
-0.026862206,
0.0034619938,
-0.017195981,
0.0015290744,
-0.01881136,
0.00023652615,
0.0043836725,
-0.004722381,
-0.01358743,
-0.016466454,
-0.0019524603,
-0.016713971,
0.009920257,
-0.02333182,
0.01862898,
0.019553915,
0.019306397,
-0.0057319934,
0.008102954,
-0.0042794542,
-0.010154747,
0.026549552,
0.00260708,
-0.025663698,
-0.00057971297,
-0.0054291096,
0.0029995262,
0.0035727255,
0.021025995,
0.02565067,
-0.0085979905,
-0.012291218,
-0.042911787,
0.019775378,
-0.0036964845,
-0.0059599704,
-0.005227187,
-0.024738763,
0.006448493,
-0.015359137,
-0.0004734594,
-0.0050350353,
-0.01786037,
0.0026543038,
-0.024321891,
0.0058036433,
-0.025533425,
-0.01123601,
0.031109093,
0.00565383,
0.011841778,
0.019228233,
0.0036052936,
-0.0063051926,
0.017326253,
-0.008493772,
-0.013509266,
-0.0018645263,
-0.023175491,
0.025051417,
-0.015359137,
-0.021976983,
-0.0025044903,
-0.04314628,
-0.02099994,
0.002326994,
-0.012375895,
-0.012688549,
0.016974516,
0.03600734,
0.028842349,
0.039915517,
-0.0055203005,
-0.022980083,
0.017378362,
0.00440647,
-0.0041882633,
0.010988492,
-0.030822493,
0.01638829,
-0.0012375895,
-0.0054160827,
0.041348517,
0.009112567,
0.0051490236,
-0.021898821,
0.0045921085,
-0.010832165,
0.0071519646,
0.013092394,
0.004054734,
-0.01014172,
0.0161538,
0.015841145,
0.008852022,
-0.007725164,
-0.025338016,
-0.010955924,
-0.029102894,
0.007008665,
0.0029425318,
-0.025025362,
-0.028555749,
0.02028344,
0.019931704,
0.008115982,
0.01786037,
-0.006689497,
-0.000791813,
0.021651303,
-0.008376527,
0.008519826,
0.0068523376,
0.0157239,
-0.02252413,
0.0036671732,
0.04447506,
-0.010057043,
-0.011822237,
0.034913052,
-0.016127745,
-0.007894518,
-0.0059599704,
-0.00008116593,
0.0036606595,
0.013313858,
0.02304522,
0.008304877,
-0.021651303,
0.02223753,
0.0027764344,
0.039785247,
0.0053607165,
0.00209576,
0.019788405,
-0.02879024,
-0.015098592,
0.020075005,
-0.022406884,
-0.032620255,
-0.014382092,
0.0072952644,
0.004513945,
0.018159997,
-0.026757987,
-0.013548348,
-0.03264631,
0.009496871,
-0.0060446477,
-0.008799912,
-0.005344433,
0.05145767,
0.012747172,
0.005526814,
-0.000012015865,
0.0058687795,
0.009386139,
0.003790932,
0.028347313,
-0.013222666,
0.029676093,
0.013782839,
0.027018532,
0.02879024,
-0.0105716195,
-0.008643585,
-0.009711821,
-0.02342301,
0.0010885902,
0.029389493,
-0.01577601,
0.07415115,
0.00315911,
-0.004953615,
0.0025565994,
-0.014329984,
0.023527227,
0.013033772,
0.023097329,
-0.032620255,
-0.032385763,
0.018967688,
-0.032099165,
0.011183901,
-0.03306318,
-0.009503385,
0.028086768,
-0.02170341,
0.017795235,
-0.014486311,
-0.0039570294,
-0.001171639,
-0.013613485,
0.015841145,
0.014082466,
-0.026484415,
0.000033102468,
0.023592364,
-0.017404417,
0.005318378,
-0.018993743,
0.018016698,
-0.005184849,
-0.04345893,
0.0035922665,
0.0032307599,
0.0133008305,
-0.010649784,
-0.025090499,
0.028451532,
0.018368434,
-0.015893254,
0.0000033872143,
-0.014186684,
-0.002939275,
0.0014956921,
-0.009789985,
-0.025298934,
0.0011170873,
-0.008050845
] |
A putative spindle matrix has been hypothesized to mediate chromosome motion, but its existence and functionality remain controversial. In this report, we show that Megator (Mtor), the Drosophila melanogaster counterpart of the human nuclear pore complex protein translocated promoter region (Tpr), and the spindle assembly checkpoint (SAC) protein Mad2 form a conserved complex that localizes to a nuclear derived spindle matrix in living cells. Fluorescence recovery after photobleaching experiments supports that Mtor is retained around spindle microtubules, where it shows distinct dynamic properties. Mtor/Tpr promotes the recruitment of Mad | [
-0.024369331,
-0.018958356,
-0.018147375,
-0.026150832,
-0.022960085,
0.02022136,
-0.021484364,
0.01209825,
-0.016086685,
-0.007431782,
0.026961813,
0.0120450705,
0.01760229,
0.0037092436,
-0.004337422,
-0.001328647,
0.021816734,
-0.015448534,
0.006527737,
-0.005962709,
-0.01724333,
0.005869645,
-0.019476853,
-0.025299966,
0.0073054815,
0.014158941,
0.012829463,
-0.038209196,
-0.029993024,
-0.003214013,
0.00799681,
-0.015900556,
0.007325424,
-0.017469341,
-0.03520458,
-0.0073918975,
0.012802873,
-0.016645065,
0.0069598174,
0.0027437103,
0.018280322,
0.0031093166,
0.0000067772216,
-0.009731779,
0.0010419784,
-0.0013992756,
0.0070794704,
-0.015076281,
-0.015209228,
0.010855188,
0.0070661753,
0.0060424777,
-0.03079071,
0.0016169776,
-0.0065809162,
-0.025579156,
-0.0034200822,
0.010084091,
0.0061621303,
-0.007883805,
-0.002876658,
-0.0016593547,
-0.03363579,
0.026523085,
-0.0033768741,
0.004829329,
0.019702863,
0.0032339552,
0.001590388,
-0.0039950814,
0.046265833,
0.019623095,
0.0098846685,
-0.026164128,
0.013693623,
-0.035337526,
-0.019038124,
-0.007810683,
-0.0036560644,
0.011559811,
0.021311533,
0.0029381462,
0.009452589,
0.013254896,
0.004360688,
0.008249411,
0.005906206,
0.0009173398,
0.0044338093,
0.020766446,
0.012789578,
0.051583745,
0.007737562,
0.018426565,
-0.012583509,
0.011081199,
-0.00022704991,
0.026430022,
-0.023797655,
-0.011978596,
-0.012217903,
-0.003356932,
-0.02111211,
-0.016831191,
-0.030870479,
0.000370592,
0.03376874,
-0.023172801,
0.0058596744,
-0.019397084,
-0.0005533952,
0.022999968,
-0.012118191,
-0.03682654,
-0.0019809222,
0.011779175,
0.027440425,
-0.0016726495,
0.0011441819,
0.0053445017,
0.022428293,
0.040549077,
0.00655765,
-0.018333502,
0.049190685,
0.015568187,
0.011234089,
0.01418553,
-0.0054840967,
0.003672683,
0.0056203683,
0.0041911793,
0.013148537,
0.0068468116,
-0.022441588,
0.0040781735,
-0.032944463,
-0.021803439,
-0.010489581,
-0.037810355,
0.006331639,
0.022149103,
-0.020713268,
-0.011433511,
-0.0105826445,
0.011273974,
0.016339285,
0.0012696515,
0.009771663,
0.01219796,
0.0035131455,
-0.021005752,
0.0063582286,
0.006687274,
0.0048758606,
0.04052249,
-0.0029132187,
-0.004819358,
-0.014810385,
-0.016711539,
-0.0021969625,
0.011160968,
0.02511384,
0.0011848973,
0.01105461,
0.025898231,
0.0020839567,
-0.014411542,
0.0008741318,
-0.019038124,
-0.005437565,
-0.0041679135,
-0.045601096,
0.025260082,
-0.028743314,
0.016392464,
-0.01668495,
0.01568784,
-0.02230864,
0.00797022,
-0.0078970995,
-0.006072391,
0.032997645,
0.0059128534,
-0.012370792,
-0.023810951,
0.021351416,
-0.014039287,
-0.0060092406,
-0.023624824,
0.0003747466,
-0.007910394,
-0.0042908904,
-0.009991027,
-0.61943036,
-0.02625719,
0.026496496,
-0.01963639,
-0.01568784,
0.025831757,
0.008934092,
0.00860837,
-0.011107788,
0.016379168,
-0.023093032,
0.020979162,
-0.011360389,
-0.025047366,
-0.03924619,
-0.030923657,
-0.0015646294,
-0.009366172,
0.045627683,
0.0049622767,
-0.034247354,
0.0147705,
0.003662712,
0.02773291,
0.00061280624,
-0.015741019,
0.033901688,
-0.0048392997,
0.007312129,
0.032944463,
-0.02075315,
0.01894506,
-0.000893243,
0.0075049032,
0.032758337,
-0.0028567158,
-0.018785523,
0.007903746,
0.0160468,
0.027187824,
-0.024435805,
0.0072257128,
0.03504504,
0.013746803,
0.00047238014,
0.018041017,
0.0060092406,
-0.012144782,
0.0046598203,
0.0058131423,
-0.0078040357,
0.0014582712,
-0.020965869,
0.01963639,
-0.011519927,
0.015847377,
0.034061227,
-0.025525978,
0.018998241,
0.00007847036,
-0.009106924,
0.0065310607,
-0.0038488389,
-0.0098846685,
0.000016527592,
-0.033476256,
-0.010243628,
0.0047861207,
0.00738525,
0.000013158457,
0.00741184,
0.018200554,
-0.0068999906,
0.0036427698,
-0.00017002776,
0.029142158,
0.005251438,
-0.0032771633,
0.0029597504,
0.017908068,
-0.014384951,
0.00064978236,
-0.019277431,
-0.024555458,
0.019955464,
-0.00027420482,
-0.032944463,
0.03613521,
0.021843323,
0.0020640146,
0.0043773064,
-0.0011815736,
-0.011347095,
-0.034140993,
-0.008395653,
-0.0064911763,
-0.0119054755,
-0.0026872074,
0.011386979,
-0.03440689,
-0.010988136,
-0.00784392,
0.02030113,
-0.0074916086,
0.008276001,
-0.000588294,
-0.035177987,
0.023904014,
0.016272811,
-0.017588994,
-0.014331773,
-0.0064978236,
-0.0057599633,
-0.025379734,
-0.0020955896,
-0.02600459,
0.045601096,
0.021205174,
-0.012856052,
-0.031189553,
0.005258085,
-0.0027835944,
0.018094195,
-0.0033519464,
0.018905178,
0.0008890884,
0.01994217,
-0.0075381403,
-0.010396518,
-0.010343338,
0.005700137,
0.013394491,
0.036427695,
-0.018001132,
0.035364114,
0.017815005,
0.016339285,
0.0072190654,
0.007837273,
-0.041479714,
-0.021617312,
-0.018280322,
-0.003586267,
-0.011220794,
0.008721376,
-0.037783764,
-0.036587235,
0.008076578,
-0.010070796,
0.0010910028,
-0.02058032,
0.00906704,
-0.022348525,
-0.0053012935,
0.0049090977,
-0.010270217,
-0.040070467,
-0.03150863,
-0.031561807,
-0.02347858,
0.011367037,
0.007558082,
-0.034460068,
0.016286105,
-0.007265597,
-0.026682623,
-0.00028022903,
0.010841893,
-0.009944496,
-0.023638118,
0.0050686346,
-0.00842889,
-0.023172801,
0.01576761,
0.00671054,
0.016764717,
0.02258783,
0.00030100212,
-0.007318776,
-0.014810385,
-0.0022634363,
-0.00041795464,
-0.019078009,
-0.011858944,
0.03802307,
0.016738128,
0.03874099,
-0.0018496362,
0.0067504244,
0.009312993,
-0.010090738,
0.010635824,
0.018240439,
-0.000664739,
-0.0024462396,
-0.021697082,
0.018426565,
-0.00012848158,
-0.0044072196,
0.029062388,
0.01540865,
-0.019782633,
-0.00082427636,
-0.026110947,
0.0076112617,
-0.025685515,
-0.007418487,
-0.03632134,
0.0009181707,
0.0013901354,
-0.008422243,
-0.02422309,
-0.004510254,
-0.0029447938,
0.00738525,
0.0080366945,
-0.010429755,
0.004935687,
-0.012357498,
-0.010562703,
-0.0019443616,
-0.008442185,
0.012364145,
0.0028085222,
0.024382627,
0.012623394,
0.008342475,
0.016365875,
0.013274837,
0.010050854,
-0.02024795,
0.012816167,
0.009844785,
0.016924255,
0.0065244134,
0.0069930544,
0.003978463,
-0.006481205,
0.044298206,
-0.0041479715,
0.00965201,
0.02528667,
-0.0050985483,
-0.011114436,
0.0050686346,
-0.018280322,
0.016897665,
-0.007265597,
-0.02416991,
0.005749992,
-0.0078970995,
-0.0026124243,
-0.015302292,
-0.007112707,
0.0030694322,
-0.00634161,
-0.002604115,
0.011533221,
0.037677407,
0.024023667,
-0.0009605478,
-0.010190449,
0.0066706557,
-0.025047366,
-0.00030391035,
0.011839001,
0.025525978,
-0.0054641543,
0.0058829403,
-0.009765016,
-0.017057203,
0.015235818,
0.016844487,
-0.024249678,
0.03262539,
0.0062884307,
-0.0042908904,
0.029461233,
0.007857215,
-0.006255194,
-0.03313059,
-0.062964074,
0.03557683,
0.011247383,
-0.02783927,
-0.025658926,
-0.039591853,
-0.003998405,
-0.00022434941,
0.008747965,
0.0025525978,
0.01596703,
-0.003170805,
0.0031757907,
-0.021378007,
-0.01115432,
0.01354738,
-0.018360091,
0.03142886,
-0.011101142,
-0.0020108356,
0.007810683,
-0.017682057,
-0.011932065,
0.032891285,
-0.0053777383,
0.016631769,
-0.0067271586,
-0.0012954101,
-0.025167018,
0.013853161,
-0.014571079,
-0.016844487,
-0.010203743,
-0.026509792,
0.005839732,
-0.013008942,
0.00505534,
0.011998539,
0.0045135776,
-0.02358494,
-0.0124638565,
0.0028849673,
-0.01342108,
0.029381463,
0.037783764,
0.0009131852,
0.010316749,
-0.015741019,
0.029301696,
0.0077973884,
-0.015873967,
0.02528667,
-0.018280322,
-0.0027919037,
-0.026988404,
-0.002800213,
0.0020208065,
0.021072226,
0.019450262,
-0.008841028,
-0.004556786,
0.011386979,
0.012955763,
0.0226676,
-0.005550571,
0.022787252,
0.03329013,
0.024967596,
-0.008502012,
-0.007850568,
0.03400805,
0.006820222,
-0.0064679105,
0.009612126,
0.008980623,
0.013866455,
0.0035962379,
-0.012025128,
-0.02258783,
0.0025642307,
0.019277431,
-0.02147107,
0.010536113,
-0.009964437,
0.019397084,
0.0018978298,
-0.0023265865,
0.0031242734,
0.000664739,
0.015847377,
-0.00030432583,
-0.014025993,
0.0019011535,
0.02722771,
-0.015262407,
-0.016738128,
-0.001874564,
-0.0047562076,
-0.012324261,
-0.022162398,
-0.011127731,
-0.026509792,
-0.0124638565,
-0.016698243,
-0.021404596,
-0.0043640113,
0.0006439659,
0.010981488,
-0.012204608,
0.0014200486,
-0.008555191,
-0.03512481,
-0.003975139,
-0.0074583716,
-0.043686647,
-0.055306286,
-0.009638716,
0.016764717,
0.03017915,
0.003302091,
-0.0147306165,
-0.004905774,
0.039565265,
-0.018280322,
-0.01719015,
0.004586699,
-0.025472797,
0.00252767,
-0.0114202155,
0.029700538,
0.014969922,
-0.010330044,
-0.0076444983,
0.020407487,
-0.019756043,
0.010496229,
-0.010436403,
-0.009266461,
0.0058463793,
0.019436968,
0.043793004,
0.0020274539,
-0.00557716,
-0.010669061,
-0.06152824,
-0.016950844,
-0.037198793,
0.0066208006,
0.005896235,
0.0040482604,
0.008721376,
-0.0081497,
-0.016658358,
-0.008089874,
0.0054973913,
-0.008369064,
-0.015222523,
0.013387843,
0.00934623,
0.012483798,
0.02567222,
-0.027134646,
0.009226577,
0.0018213849,
-0.00038554863,
0.045654275,
0.011327152,
0.009206635,
0.0211387,
-0.015608071,
-0.0047861207,
-0.009738427,
0.0014109085,
0.004280919,
0.030631173,
-0.008089874,
-0.029966434,
-0.008595075,
-0.017562404,
-0.012669926,
0.003878752,
0.0058663217,
0.011619638,
-0.010496229,
0.024382627,
-0.005906206,
-0.017150266,
0.0106158815,
-0.029514411,
-0.009439293,
0.011347095,
0.0015770933,
0.026071064,
0.014850269,
0.0051018717,
-0.0244491,
-0.0036427698,
0.0019493471,
-0.037119024,
-0.010436403,
-0.02269419,
0.02528667,
0.016139863,
0.047409184,
0.0055339523,
0.0075780246,
0.011845649,
0.031482037,
-0.021284943,
-0.0066208006,
0.030684352,
-0.007378603,
0.04038954,
0.015195933,
0.008701433,
0.021564133,
-0.018612692,
0.001416725,
0.024528868,
-0.009140161,
-0.010403166,
0.0055838074,
-0.023651414,
-0.023877425,
0.009033803,
-0.0028517302,
-0.010861835,
-0.023332339,
-0.013347959,
0.018825408,
0.006447968,
0.02024795,
-0.0011948684,
0.028264701,
-0.010988136,
0.030125972,
-0.007857215,
0.005686842,
-0.010310101,
-0.015062986,
0.0040814974,
-0.0051816404,
0.026071064,
-0.013839866,
0.013381196,
0.011400274,
0.009266461,
-0.0009946157,
0.027134646,
-0.014637552,
-0.0077774464,
-0.008847676,
-0.043660056,
-0.028105164,
-0.02959418,
-0.0073653082,
-0.043872774,
0.006338286,
0.0093262885,
-0.017070496,
0.017535815,
-0.0028583778,
-0.0013170141,
0.027307479,
-0.0025492741,
0.020407487,
0.0010494567,
0.029541,
0.011400274,
-0.014983217,
0.002092266,
-0.01933061,
-0.0028234788,
0.011659522,
0.032838106,
0.016432349,
-0.024183204,
-0.016751423,
0.019184368,
-0.026217306,
-0.018758934,
-0.039671622,
-0.0018629311,
0.0024545488,
0.020806331,
0.007119355,
0.0012505403,
-0.015076281,
-0.0008288464,
-0.009718484,
0.008162995,
0.005058664,
-0.009233224,
-0.014079172,
0.009459236,
-0.009844785,
0.009332935,
-0.007212418,
-0.028583776,
0.021165289,
-0.022906905,
0.015129459,
0.0011524912,
-0.006906638,
0.03400805,
0.0137202125,
0.0015139431,
0.019264136,
0.040123645,
-0.018479744,
-0.016831191,
-0.009027155,
0.043154854,
0.00490245,
0.022268755,
-0.0054840967,
0.003443348,
0.018080901,
-0.020673383,
0.0035995618,
-0.004420514,
-0.0211387,
0.003868781,
0.021524249,
0.0076777353,
-0.0150098065,
-0.00520823,
-0.033662383,
0.0093262885,
-0.018798819,
-0.023412107,
0.021284943,
-0.04291555,
-0.020341013,
0.0059327953,
0.034805734,
0.009711836,
0.00031658195,
-0.0046265833,
-0.007671088,
0.040814973,
0.0000020870468,
0.025127133,
0.00799681,
-0.0039585205,
-0.04631901,
0.009279756,
-0.0048958026,
-0.025831757,
-0.0062684887,
-0.008595075,
-0.016871076,
0.012769636,
-0.001634427,
0.013394491,
0.004270948,
-0.018758934,
0.018027721,
0.004413867,
-0.0027819327,
-0.01173929,
0.01115432,
-0.0011691097,
-0.03009938,
-0.0001578755,
-0.0007856384,
-0.007877157,
-0.0075780246,
-0.018453155,
-0.024941007,
0.019064715,
-0.026297074,
0.00447037,
-0.008654902,
-0.0046066414,
-0.018333502,
0.00047238014,
-0.009904611,
-0.012337556,
-0.01624622,
0.0041047633,
0.0058031715,
0.0023232629,
-0.03698608,
-0.013932929,
0.0023348958,
0.0026456611,
-0.02450228,
-0.010070796,
0.016405758,
-0.024980891,
-0.02628378,
-0.0031309207,
-0.019091304,
0.023465287,
-0.018918471,
-0.0422774,
-0.010010969,
-0.008515307,
-0.040123645,
-0.032944463,
0.012942468,
0.014012698,
0.008049989,
0.007039586,
-0.005201583,
-0.016033504,
0.013480906,
0.024635227,
0.015820788,
-0.0071060597,
0.009053745,
-0.01250374,
0.018041017,
0.010881777,
-0.051158313,
-0.020327719,
0.025552567,
-0.005753316,
-0.011021373,
0.029780308,
-0.009273109,
0.014810385,
-0.010090738,
0.01029016,
0.0020756475,
0.007956926,
0.040549077,
-0.036534056,
-0.02019477,
0.0077973884,
0.008216174,
-0.009838137,
0.008561838,
0.0017416162,
0.008728023,
-0.007531493,
-0.020380897,
-0.007558082,
0.009618773,
-0.009944496,
0.026523085,
0.026576266,
0.026190717,
0.009971085,
0.031242732,
-0.0035064982,
-0.011214146,
-0.016179748,
-0.018360091,
-0.009359525,
0.010542761,
0.0054774494,
-0.002059029,
0.0072788917,
-0.0016975772,
-0.02839765,
0.0047794734,
-0.006364876,
-0.02230864,
-0.038980294,
0.023824245,
0.00003287342,
-0.008615017,
-0.013986109,
-0.0005263902,
-0.0024030316,
-0.00723236,
0.018466448,
-0.0050387215,
-0.010609235,
-0.014291888,
-0.0059660324,
-0.015913852,
0.0018828732,
-0.018014427,
-0.0007752518,
-0.0112806205,
0.020274539,
0.19208299,
0.00085917517,
-0.008668196,
0.03501845,
0.010150565,
0.010097385,
0.025592452,
-0.0035264404,
-0.0035530298,
-0.009319641,
0.007857215,
0.007431782,
-0.009971085,
-0.002625719,
0.02386413,
-0.0049323635,
-0.014305183,
-0.0010702298,
-0.02416991,
-0.010655766,
0.013640444,
-0.018785523,
0.012051718,
-0.004792768,
0.016897665,
0.013148537,
-0.029115567,
-0.019383788,
-0.0028201551,
0.01102802,
-0.027440425,
-0.008030047,
0.006015888,
-0.017176855,
0.0069864066,
0.0089075025,
-0.013387843,
-0.00030806498,
-0.007704325,
0.008043342,
-0.0069997017,
0.008860971,
-0.008030047,
0.0020507197,
0.010276865,
0.017615583,
-0.003606209,
-0.0040017287,
-0.002125503,
0.0052713803,
-0.062538646,
0.0144514255,
0.03017915,
0.03570978,
-0.01719015,
-0.008634959,
0.00037848577,
0.009379467,
-0.0044969595,
0.016286105,
-0.016924255,
0.0013452655,
-0.04060226,
0.032306314,
-0.015461829,
0.018878587,
-0.005906206,
0.033901688,
0.030072792,
-0.03560342,
0.0069332276,
0.008182937,
-0.0065543265,
-0.006298402,
0.021125406,
-0.019436968,
0.004998837,
0.0110679045,
0.03491209,
0.005869645,
0.0038820757,
-0.012895936,
0.00020222606,
-0.003978463,
0.021763554,
-0.030604584,
0.015953736,
0.012669926,
0.011466748,
-0.022375114,
0.0070528807,
-0.03919301,
-0.009133514,
-0.013048827,
0.0040183472,
0.0059128534,
0.009273109,
0.0030561376,
-0.02681557,
-0.011566458,
-0.042756014,
0.050998777,
0.02962077,
-0.0006107289,
-0.005115167,
-0.0010752153,
0.0050187795,
0.011559811,
0.013108653,
-0.0244491,
0.020965869,
-0.032705158,
0.014438131,
0.0020424107,
-0.0060590957,
0.015541597,
0.015953736,
-0.041426536,
0.03908665,
-0.012264434,
0.0118722385,
-0.018931767,
0.011991891,
-0.0035829432,
-0.012856052,
-0.018240439,
0.0096054785,
-0.014424836,
-0.025193607,
-0.016831191,
-0.014305183,
-0.004769502,
0.0048858314,
0.010549407,
0.00998438,
-0.01222455,
0.01777512,
-0.015435239,
0.0020091736,
-0.0009580551,
-0.0002517699,
0.005108519,
0.008049989,
0.017469341,
-0.01621963,
-0.011187557,
-0.004629907,
0.03265198,
-0.011978596,
-0.02567222,
-0.017163562,
-0.015820788,
0.0029265133,
-0.010954899,
-0.0017067174,
-0.019450262,
-0.017389571,
-0.039538674,
-0.0053245593,
0.0065011475,
-0.03257221,
0.0124638565,
0.007724267,
0.009459236,
-0.014584374,
-0.0022584507,
-0.16698244,
-0.005204906,
0.030445047,
-0.022188988,
0.036055442,
0.009199988,
0.0071525914,
0.014969922,
0.0042842426,
0.0062485468,
-0.00044703696,
0.010356634,
-0.026323665,
-0.027972218,
-0.011480043,
0.028344471,
-0.0062319282,
0.016871076,
0.026097653,
0.0069132857,
0.03507163,
-0.032891285,
0.017987838,
-0.017615583,
0.0035563535,
0.029727127,
0.014119056,
0.013866455,
0.013667034,
-0.028264701,
-0.0013361254,
0.012816167,
0.03738492,
-0.004782797,
0.024648521,
-0.0046664677,
0.0016792968,
-0.0081762895,
0.0035497062,
0.005171669,
0.019383788,
0.009399409,
0.009997674,
-0.020088412,
0.0008516968,
0.034832325,
-0.018173965,
-0.0050952244,
0.019888991,
-0.009598831,
0.043793004,
-0.003529764,
0.018027721,
0.025339851,
0.019011535,
0.012058365,
0.0024977569,
0.023319043,
0.004294214,
-0.005916177,
-0.0137202125,
-0.0018911824,
0.025725398,
-0.011952007,
0.003649417,
-0.04421844,
-0.008854323,
0.017309804,
-0.04052249,
0.0055937786,
-0.025964705,
0.017668763,
0.014252004,
-0.0131153,
0.0142785935,
0.018612692,
-0.00680028,
0.025964705,
-0.008355769,
-0.004945658,
-0.018200554,
0.027440425,
-0.0013610531,
-0.037677407,
-0.007265597,
0.00049855426,
0.009725131,
0.001067737,
-0.0074517243,
0.00965201,
0.013799981,
-0.013347959,
0.021444479,
-0.016232926,
0.051636923,
0.0059760036,
-0.008043342,
-0.011127731,
0.020101707,
-0.022401704,
0.0027935656,
0.0050154557,
-0.015395355,
0.019649684,
0.017788416,
0.007943631,
-0.0062352517,
0.015900556,
0.035736367,
-0.0036560644,
0.006135541,
-0.012929173,
0.010968193,
0.030631173,
0.013853161,
0.037225384,
0.008754613,
0.0063549047,
0.012623394,
-0.009824842,
0.075833425,
-0.004998837,
-0.015023101,
-0.007531493,
0.0012031776,
-0.02414332,
-0.119333945,
-0.016711539,
0.0038222491,
0.032971054,
-0.013959519,
0.012404029,
0.0018712402,
0.050307445,
-0.008880913,
0.024847943,
-0.020646794,
-0.037703995,
0.017721942,
0.010509524,
-0.013308074,
-0.02294679,
0.023358928,
-0.007445077,
-0.019423673,
0.03448666,
-0.0012106559,
0.010436403,
-0.004829329,
-0.0012056703,
0.022375114,
0.010423107,
-0.023850836,
0.026616149,
0.018067606,
0.007245655,
-0.013341311,
-0.030498225,
0.036667004,
-0.0011699406,
-0.030631173,
-0.017309804,
-0.025685515,
-0.017549109,
0.0241965,
-0.010961546,
0.0048658894,
0.008003457,
0.012171371,
0.0008816101,
-0.0017848242,
-0.014677437,
-0.0090138605,
0.016950844,
0.011745938,
0.005527305,
-0.021537544,
-0.015488419,
-0.023159506,
-0.015873967,
0.008555191,
-0.028450828,
0.029301696,
0.010655766,
-0.0075115506,
-0.0009281418,
-0.0043739825,
0.0045268727,
0.018652577,
-0.006428026,
0.022561241,
-0.009166751,
0.0038853993,
-0.045361787,
0.03140227,
-0.02962077,
0.003453319,
0.0090138605,
-0.01877223,
-0.021457775,
-0.025073955,
-0.0020723238,
-0.020487256,
-0.036055442,
0.012869347,
-0.027334068,
-0.027653143,
-0.030125972,
0.037039258,
-0.032332905,
0.032465853,
0.004390601,
0.012297671,
-0.0034499953,
0.020620203,
-0.007498256,
-0.0047894446,
0.044936355,
-0.0013934592,
-0.01657859,
-0.021524249,
0.020208064,
0.0034200822,
0.014438131,
0.03499186,
0.009731779,
-0.029461233,
-0.019224253,
-0.07354672,
0.0032339552,
0.025167018,
-0.012789578,
0.00921993,
-0.0042210924,
0.009552299,
0.012284377,
0.0009447603,
0.011273974,
-0.037039258,
-0.0075381403,
-0.00004538921,
-0.011839001,
-0.039910927,
-0.012144782,
0.033529434,
-0.029886665,
0.0145179,
0.036454286,
-0.0069132857,
0.0021554162,
0.028636957,
0.040070467,
0.0063482574,
-0.008980623,
-0.019224253,
0.020048529,
-0.010097385,
0.018240439,
0.0027304154,
-0.025260082,
-0.008189584,
0.011706053,
-0.013155185,
-0.003825573,
-0.022787252,
0.021564133,
0.015448534,
0.03392828,
-0.005401004,
-0.03749128,
0.005284675,
-0.00361618,
-0.003572972,
-0.003572972,
-0.036055442,
-0.00076943537,
0.012470503,
-0.020726562,
0.019795926,
0.005314588,
-0.0076843826,
-0.023398813,
-0.015554893,
0.0052979696,
0.0038122782,
-0.0032322933,
0.00007275776,
-0.03866122,
0.023039853,
0.026124243,
-0.0007615416,
0.009971085,
0.009485825,
-0.010775419,
-0.03789012,
0.0017815005,
-0.0068135746,
-0.025419619,
-0.023571644,
0.012184666,
0.015860673,
0.0060092406,
-0.01777512,
-0.00655765,
-0.015834082,
-0.014610963,
-0.018267028,
0.021351416,
0.0057067843,
0.014504605,
-0.015807493,
0.017947953,
0.02539303,
-0.016073389,
-0.0029763689,
0.03017915,
-0.0019875695,
0.0076577934,
0.002123841,
0.012184666,
0.0121514285,
0.0064645866,
-0.013088711,
0.016432349,
-0.014850269,
0.024342742,
0.017362982,
0.005862998,
0.0034965272,
-0.007531493,
0.008701433,
-0.01877223,
-0.009765016,
0.0241965,
-0.039777983,
-0.020606909,
0.010682356,
0.0026007914,
0.0067504244,
0.006906638,
0.00043540404,
0.0063781706,
-0.018094195,
0.01115432,
0.019210957,
-0.02416991,
0.01657859,
0.00038991097,
0.028211523,
0.023691298,
0.011114436,
0.0072788917,
0.024794765,
0.019064715,
0.02478147,
-0.032226548,
0.021404596,
-0.026669329,
0.022149103,
0.013866455,
-0.03243926,
-0.029301696,
-0.0067869853,
-0.005317912,
-0.014810385,
-0.00073370564,
0.014424836,
0.10380564,
0.021630608,
-0.013055474,
0.0063017257,
-0.018306911,
0.02030113,
0.02121847,
0.018399976,
-0.006504471,
-0.032412674,
0.009991027,
-0.018905178,
0.017349688,
-0.022122514,
0.0024479013,
0.029301696,
-0.02322598,
0.010190449,
-0.019503443,
-0.014212119,
0.0025841729,
-0.039139833,
0.004457075,
0.021537544,
-0.021072226,
0.014983217,
0.03685313,
0.004762855,
0.012357498,
-0.011878886,
0.023983782,
-0.01207166,
-0.023438698,
-0.002353176,
0.014331773,
0.0047129993,
-0.008867619,
-0.012231197,
0.029487822,
0.018080901,
-0.015780903,
-0.0045933463,
-0.0011583077,
-0.008083226,
0.012636689,
0.008801145,
0.018984945,
-0.019702863,
-0.022268755
] |
BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease. Homocysteine reduction is known to be maximal at a folic acid dosage of 1 mg/d, but the effect of lower doses (relevant to food fortification) is unclear. METHODS We randomized 151 patients with ischemic heart disease to 1 of 5 dosages of folic acid (0.2, 0.4, 0.6, 0.8, and 1.0 mg/d) or placebo. Fasting blood samples for serum homocyste | [
-0.0145660825,
-0.0059484695,
0.013326138,
-0.023963556,
-0.027330983,
0.029523727,
-0.030541787,
-0.0068131676,
-0.025673373,
0.0031112814,
0.009110328,
0.029367102,
0.0000040500854,
0.009899977,
-0.003713307,
0.022423415,
0.045264494,
0.003320114,
0.011492326,
-0.0033250086,
-0.008314153,
0.04069628,
0.015009852,
0.014905436,
-0.0018909151,
-0.01422673,
0.015740767,
-0.03223855,
-0.0028192417,
-0.01576687,
0.030698411,
-0.015349206,
-0.00066116767,
-0.0076419725,
-0.006444447,
-0.0030590731,
-0.004219074,
0.008757923,
0.006356346,
-0.026665328,
0.0087775,
0.005122928,
0.018781893,
0.0050380896,
-0.02941931,
-0.019760797,
-0.006121409,
-0.0006876796,
-0.033726484,
0.020935481,
0.03529273,
-0.0002961183,
0.0134827625,
0.020060994,
-0.010200174,
-0.0016119276,
0.008562142,
0.030646203,
-0.00999134,
-0.012412495,
-0.011746841,
-0.006444447,
-0.038947303,
0.021261781,
-0.004825994,
0.014305042,
0.014840175,
0.03304778,
0.0014781442,
0.023689462,
0.0011436854,
0.030724514,
-0.009913028,
0.0033870058,
0.029132165,
0.011635899,
-0.045864888,
-0.017646365,
0.033282716,
-0.014174521,
0.026652277,
0.009018963,
-0.023872191,
0.03657183,
0.031298805,
0.010591735,
-0.017437533,
0.02564727,
-0.00452906,
0.011681581,
0.019617224,
0.01844254,
0.004587794,
0.00479989,
-0.004049397,
0.016419474,
-0.0104742665,
0.022462571,
0.012595224,
-0.0022286368,
-0.014017897,
-0.034796752,
-0.024877198,
0.0015132215,
-0.016863242,
-0.018468644,
-0.018233707,
-0.001082504,
-0.0061605657,
-0.019512808,
-0.025934415,
0.044455267,
-0.00041970483,
-0.039156135,
0.014135365,
-0.0039417176,
0.006323716,
0.011342227,
0.0022025327,
0.00037810145,
0.00085327745,
0.008640454,
0.032525696,
-0.008151002,
0.0058310013,
0.0010343746,
-0.031324908,
-0.011707685,
-0.0035403674,
0.008464252,
0.025438437,
0.013613284,
0.0062192995,
-0.0041179205,
-0.050641935,
0.03171647,
-0.01665441,
0.0074722962,
-0.022384258,
-0.035632085,
0.014957644,
0.0055732233,
-0.0030623362,
-0.01192957,
-0.025738634,
0.0046628434,
0.021979645,
0.023571994,
-0.012144928,
-0.017359221,
-0.0030541786,
-0.03043737,
0.03803366,
0.0008165686,
-0.004349594,
0.0065553896,
0.0035925754,
0.00071908615,
-0.015035956,
0.013939585,
0.00092751096,
-0.005821212,
-0.00969767,
-0.005824475,
0.0026691433,
0.011198655,
0.014631343,
-0.013822116,
-0.011949148,
-0.009854294,
0.0076941806,
0.041374985,
-0.004568216,
0.0017750781,
-0.0011885519,
0.00011971173,
0.013691596,
0.004943462,
-0.0076550245,
-0.020583076,
-0.02513824,
0.02641734,
0.023898296,
0.017359221,
-0.013169514,
0.036206376,
0.018703582,
-0.005145769,
0.018938517,
-0.011877362,
-0.01856001,
0.014148417,
-0.008164055,
-0.022188477,
-0.6290042,
-0.017711626,
-0.014187573,
-0.02131399,
0.0024374695,
0.027592024,
0.008529511,
0.0017310275,
-0.006026782,
0.011159499,
0.013391399,
0.039782636,
0.0099326065,
-0.039417177,
0.004620424,
-0.033909213,
-0.015179529,
-0.02042645,
-0.00493041,
-0.00044907193,
-0.02795748,
0.008431621,
-0.008705715,
-0.0047281035,
0.030985557,
0.02814021,
0.018690528,
-0.0041994955,
-0.014787967,
0.0020834329,
0.00685885,
0.013215196,
-0.00063098484,
0.018285915,
0.04576047,
-0.01696766,
0.019290924,
0.00232979,
0.0020410137,
0.022084061,
-0.004578005,
-0.005253448,
0.034379087,
-0.01215798,
-0.009169062,
0.021353146,
0.014670499,
0.015101217,
0.01155106,
0.0076550245,
0.01017407,
0.002554938,
-0.017816043,
-0.024485637,
-0.0019219137,
0.02500772,
0.02016541,
-0.02010015,
0.009240848,
0.012895421,
-0.017150387,
0.00959978,
-0.022449518,
-0.007700707,
-0.0041211834,
0.015531934,
-0.013900428,
0.010559104,
0.020818012,
0.0047411555,
0.012621328,
0.011035505,
-0.0019055987,
-0.020060994,
0.043698248,
-0.0030900717,
0.018912414,
0.0010156123,
-0.035083897,
0.019055987,
0.012118824,
0.0023624203,
-0.006261719,
-0.017555,
0.016458629,
0.016641358,
0.0032189607,
-0.0026870898,
0.01397874,
-0.017463638,
0.008705715,
0.013313087,
0.0044409586,
-0.033961423,
-0.0061899326,
-0.0024293119,
0.017881302,
0.007903013,
0.021927437,
-0.010670047,
-0.028375147,
-0.022867184,
0.0018843891,
0.03286505,
0.0074592438,
-0.004294123,
-0.0363891,
-0.015792975,
0.013743804,
-0.008823182,
0.006134461,
-0.0029269212,
-0.030489579,
-0.009018963,
0.0065390747,
-0.015427518,
-0.041296672,
-0.009919555,
-0.003687203,
-0.04051355,
0.020308983,
0.0103111155,
0.018533904,
0.034744546,
-0.0026120406,
-0.0031993827,
0.0024097338,
-0.0015164845,
-0.0061507765,
-0.03560598,
0.016471682,
0.01760721,
0.03693729,
-0.016236745,
0.016563045,
-0.008934125,
0.043150064,
-0.010585208,
0.007374406,
-0.016758826,
-0.0127779525,
0.0028420829,
0.01340445,
-0.010128387,
0.0018174973,
-0.028244626,
-0.0058668945,
0.012295027,
-0.0006884954,
-0.0044931667,
0.01094414,
-0.024355117,
-0.012901947,
0.022384258,
-0.008340257,
-0.016288953,
0.0025957255,
-0.034091942,
-0.015453622,
-0.03195141,
0.02572558,
0.0070024226,
-0.009338738,
0.011707685,
-0.023441473,
0.0015833763,
0.003791619,
0.00229716,
-0.011290019,
-0.023115173,
-0.0018044453,
-0.011564112,
-0.0081966845,
-0.0021829547,
-0.010957192,
0.01760721,
-0.013900428,
0.021796916,
-0.03967822,
-0.0036186797,
0.013215196,
-0.034744546,
-0.016889347,
0.016458629,
0.023180433,
0.002987287,
0.010702677,
-0.000023949993,
-0.007929117,
0.02412018,
0.016275901,
0.0012260765,
0.0010213226,
0.00019394523,
0.009032016,
-0.007726811,
-0.0120992465,
-0.029706456,
-0.0014683551,
0.012921525,
0.029628143,
-0.01926482,
0.0040689753,
-0.0126148015,
0.046935156,
-0.0070676827,
-0.010859302,
-0.008992859,
0.016824087,
0.014057053,
-0.0031406484,
-0.017763834,
-0.010493845,
-0.018990725,
-0.007961748,
-0.016563045,
-0.0030443897,
-0.017855199,
-0.00074641383,
0.0066565434,
0.030332953,
-0.00062038004,
0.0110420305,
0.009880398,
0.0028306623,
0.011394436,
0.021914383,
-0.00042459936,
0.025895258,
0.00083451514,
-0.01435725,
-0.00232979,
-0.015636351,
-0.0016983974,
0.020113202,
0.014879332,
0.003439214,
-0.015584142,
0.023767775,
0.027017735,
0.005752689,
-0.0018452329,
0.016184537,
-0.0061377245,
-0.01091151,
-0.0067674858,
0.043698248,
0.024603106,
0.00046701852,
0.018703582,
0.0006844166,
0.02087022,
-0.013006363,
-0.033334926,
-0.027539816,
0.0093909465,
-0.010865828,
0.007785545,
0.014148417,
0.048449192,
0.031925302,
0.022345101,
-0.001729396,
-0.018011823,
-0.022318998,
0.00665328,
-0.0127649,
0.01286279,
-0.0137177,
0.003416373,
-0.030332953,
-0.015127321,
-0.018977674,
-0.0065129707,
0.013796012,
0.011192129,
0.02374167,
0.023650307,
0.023819983,
0.010519949,
-0.019382287,
-0.020478658,
0.013665492,
0.01640642,
-0.008451199,
0.012177559,
-0.006036571,
0.0058734203,
0.02858398,
0.010696151,
0.00057714514,
-0.007765967,
0.009854294,
-0.010232803,
-0.03043737,
-0.021901332,
0.005455755,
-0.0117207365,
0.020087099,
-0.013900428,
-0.033622067,
-0.028766708,
-0.011792523,
-0.0061703543,
0.0414794,
0.040435236,
0.012281975,
0.0026430392,
0.020844117,
0.0036121535,
0.02385914,
0.0050380896,
0.024511741,
-0.00027225752,
0.0044801147,
0.012608276,
-0.011877362,
-0.002594094,
0.018703582,
-0.0075897644,
0.0069958963,
-0.02500772,
-0.006343294,
-0.006535812,
0.007661551,
0.004072238,
0.0025516748,
-0.0043822243,
0.043150064,
0.026456496,
-0.008823182,
-0.016419474,
0.019826056,
0.0029921813,
0.0069436883,
0.0022253736,
-0.006052886,
-0.0069306362,
0.014435562,
0.024407325,
-0.010023971,
-0.032395177,
-0.018533904,
-0.007909539,
-0.004010241,
-0.02462921,
0.002881239,
0.032786738,
0.008248893,
0.007916066,
0.0120470375,
0.03790314,
0.0024570476,
-0.009175588,
0.012810582,
0.015988756,
0.002639776,
-0.0035925754,
-0.012934577,
-0.015336153,
-0.03534494,
-0.0122623965,
0.015336153,
-0.007720285,
0.0097955605,
0.0015482989,
-0.009397472,
0.019786902,
-0.0035958386,
-0.012445126,
-0.009077698,
0.01799877,
-0.011746841,
-0.02430291,
0.017463638,
0.011524956,
-0.008562142,
-0.00047966267,
0.012445126,
-0.03375259,
0.0032140661,
-0.0067544337,
-0.02271056,
0.011290019,
-0.010774463,
-0.01990437,
0.015845183,
-0.006248667,
-0.017059023,
0.004568216,
-0.024146285,
-0.008666558,
-0.012849739,
0.004881465,
0.0049238843,
-0.018612217,
-0.022619195,
0.0110420305,
0.012086194,
0.0070742085,
-0.0040983423,
-0.0274354,
-0.011851258,
0.010389429,
-0.018546956,
0.013058571,
-0.029079957,
-0.019499756,
0.0088492865,
-0.013091202,
-0.0135349715,
-0.00665328,
-0.015714662,
0.010043549,
0.017463638,
-0.0039123506,
0.023350108,
-0.031820886,
-0.027069943,
-0.0018158659,
-0.004623687,
0.002419523,
0.002171534,
0.00065627316,
0.0007884251,
-0.00031141363,
-0.0069828443,
-0.042523563,
-0.010519949,
-0.02438122,
-0.010232803,
-0.016484734,
0.029993601,
-0.010356798,
0.011772945,
-0.009175588,
0.002755613,
-0.004953251,
0.028766708,
0.029132165,
0.005211029,
0.0145660825,
-0.014122313,
-0.0010384533,
0.006291086,
-0.010748359,
0.03234297,
-0.015714662,
-0.022110164,
0.011146447,
0.021548927,
-0.032264657,
-0.025320968,
0.029236581,
0.002722983,
0.031612054,
-0.02182302,
-0.025151292,
-0.01811624,
-0.017398376,
0.012725744,
-0.007126417,
0.006085516,
-0.0041538132,
0.01247123,
0.0033870058,
-0.01908209,
-0.011107291,
0.010931088,
-0.029210478,
0.008705715,
-0.017450584,
-0.017215649,
-0.0010466109,
0.006878428,
-0.011988304,
-0.030724514,
0.005455755,
-0.03482286,
-0.017333116,
-0.00820321,
0.006715277,
0.020583076,
0.03145543,
0.03962601,
-0.018520853,
-0.01703292,
-0.008503407,
0.025790842,
-0.0006917584,
0.01819455,
0.023402318,
-0.018925466,
0.015231737,
0.014448614,
0.0007643604,
0.022697506,
-0.012986785,
0.024537845,
0.046752427,
-0.009358317,
-0.01570161,
-0.014905436,
-0.034927275,
0.013189092,
-0.009234322,
-0.010650469,
-0.0044507473,
-0.022005748,
-0.027644232,
0.010643943,
-0.000993587,
0.018873258,
-0.014174521,
0.015988756,
-0.021836072,
-0.0012236292,
-0.008079216,
-0.007413562,
0.003713307,
-0.02354589,
0.017620262,
0.007955221,
0.011544534,
0.022423415,
0.0067544337,
0.00679359,
-0.008477303,
0.01250386,
0.021666395,
-0.023389265,
-0.0038731946,
0.008366361,
-0.0089275995,
0.009651988,
0.011205181,
0.0024244175,
-0.018468644,
-0.005697218,
-0.0035566825,
-0.02827073,
0.003785093,
0.00089406513,
-0.005703744,
-0.011805575,
-0.030959452,
0.021105157,
-0.03312609,
0.021796916,
0.013796012,
-0.0034979482,
-0.0252035,
0.01250386,
-0.0072504114,
0.014331146,
0.04502956,
0.036467414,
-0.008124898,
-0.007159047,
-0.0076223947,
0.01164895,
-0.010735308,
-0.03427467,
0.0331783,
0.022880236,
0.021836072,
-0.0017342905,
0.008033534,
-0.025947466,
0.025190448,
0.045107868,
-0.022162372,
0.0014079894,
-0.02475973,
-0.012144928,
0.013548023,
0.014305042,
0.018651374,
0.012817109,
0.009312634,
-0.012908473,
-0.024720574,
-0.0026756693,
0.0051947143,
-0.012875843,
0.03769431,
0.004685684,
0.0022498462,
-0.026521757,
-0.016771879,
-0.004245178,
-0.0011249231,
-0.01570161,
0.031429324,
-0.014579135,
-0.003409847,
0.010970244,
0.0068131676,
-0.016119275,
0.002590831,
-0.0024015764,
-0.020791909,
-0.049780503,
-0.002323264,
0.023519786,
0.002006752,
-0.00854909,
0.011570638,
-0.014840175,
0.0038470903,
-0.012830161,
-0.018064031,
0.025255708,
-0.028505668,
0.017594157,
-0.034379087,
0.016680514,
0.0028942912,
-0.002103011,
-0.0135088675,
0.00015274972,
0.005217555,
-0.02036119,
0.022619195,
0.012758374,
0.020113202,
-0.009051594,
-0.010389429,
-0.025869153,
-0.00864698,
-0.0068523237,
-0.019369235,
-0.036128063,
-0.04542112,
-0.0039515067,
0.012719219,
0.0059582586,
-0.023963556,
0.020765804,
0.014004845,
0.006039834,
0.010506896,
-0.015558038,
0.015114268,
-0.026339028,
-0.0006521944,
0.041009527,
-0.010461214,
-0.011166025,
-0.032630112,
0.021457562,
0.014239782,
0.015035956,
0.014827124,
-0.009723774,
-0.0032776948,
-0.017045971,
0.011048556,
-0.036258582,
0.00018344242,
-0.030933348,
-0.0061279354,
0.01304552,
-0.0264826,
-0.013730751,
-0.0016853453,
-0.008464252,
-0.0079748,
-0.008979808,
-0.000709705,
0.00011869204,
-0.012131876,
-0.0033184825,
0.0090646455,
-0.0052567115,
0.025503697,
0.010409006,
-0.016980711,
0.014383354,
-0.0031129129,
-0.06990676,
-0.020556971,
0.00046987363,
-0.0010735308,
0.016419474,
0.029810872,
0.0031471744,
0.02284108,
-0.024094075,
0.02207101,
-0.023754723,
-0.0038699314,
-0.011237811,
0.001274206,
0.006105094,
-0.011159499,
-0.014017897,
-0.004571479,
0.018807998,
-0.0019496493,
-0.029967496,
0.021940488,
0.014278938,
0.028296834,
0.0016013228,
0.02610409,
0.004620424,
-0.020713596,
-0.013939585,
-0.0023477366,
0.0030313376,
-0.01927787,
0.009573676,
-0.027853064,
-0.02699163,
-0.014448614,
-0.014083157,
-0.014148417,
-0.023833035,
-0.0194606,
0.0090646455,
-0.02725267,
-0.01040248,
0.02239731,
-0.010963718,
-0.0013419135,
0.027618129,
0.03312609,
0.0127649,
0.0053317607,
-0.007857331,
-0.0012203662,
0.008242367,
0.018024875,
-0.01215798,
0.0029742348,
0.0149445925,
0.004760734,
0.02143146,
-0.0038470903,
-0.01378296,
-0.032786738,
0.024890251,
-0.019160403,
-0.0021699027,
0.0018028137,
-0.0090385415,
-0.017359221,
0.01996963,
-0.010004393,
0.005096824,
-0.013391399,
-0.017946562,
0.010996348,
-0.01209272,
-0.01608012,
-0.0024733627,
-0.008366361,
-0.0025924626,
0.034352984,
0.17917848,
-0.0033217457,
0.00030325612,
0.02214932,
-0.009103802,
0.012184084,
0.01703292,
-0.0019822794,
-0.0055666976,
0.0033054305,
0.014513874,
-0.024224596,
-0.01164895,
-0.0032369073,
0.017842146,
-0.012510385,
-0.009456207,
-0.018285915,
0.0006216037,
-0.0037557262,
0.005126191,
-0.006134461,
0.0056025903,
-0.011531482,
0.020191515,
0.0016869769,
-0.0037100438,
-0.00066198345,
0.030019704,
-0.012203663,
0.0007872015,
-0.007557134,
-0.009364842,
-0.0032075401,
-0.00057714514,
-0.013691596,
-0.0016217167,
-0.003039495,
-0.018364228,
0.00685885,
-0.028871125,
0.0053089196,
-0.065103605,
-0.004835783,
-0.0115836905,
0.025320968,
-0.007478822,
-0.02323264,
-0.024785833,
0.015753819,
-0.049728293,
-0.003303799,
0.007217781,
0.03330882,
-0.005716796,
-0.031246597,
0.032447387,
-0.0018207603,
-0.0026430392,
0.025059927,
0.018612217,
0.0030443897,
-0.0078116492,
0.03657183,
-0.041453294,
0.031846993,
-0.026430393,
-0.029106062,
-0.008444673,
-0.007126417,
0.011329176,
0.0061736177,
-0.010872354,
0.005990889,
0.003135754,
-0.003303799,
0.028322939,
0.030724514,
0.0062454036,
0.026665328,
-0.030150225,
-0.035188314,
0.009469259,
0.027148254,
-0.008855813,
-0.041531608,
-0.00329401,
0.009384421,
-0.019408392,
-0.018468644,
0.018807998,
-0.025673373,
0.0013680175,
0.013626335,
0.016928503,
-0.017280908,
-0.012556068,
0.013952636,
0.010409006,
0.0050478787,
-0.005501437,
0.0670353,
-0.023793878,
0.017842146,
-0.005524278,
-0.0035436302,
-0.035814814,
0.027905272,
-0.010037023,
0.004375698,
0.0003815684,
-0.05074635,
0.0030492842,
-0.005397021,
0.0019219137,
0.020191515,
-0.0056613246,
-0.03719833,
0.029706456,
-0.016393369,
-0.016197588,
-0.0090385415,
0.0037883562,
0.028871125,
-0.023376213,
-0.014592187,
-0.02941931,
0.005723322,
-0.004545375,
-0.04643918,
0.0016886084,
-0.0041374983,
0.0022139533,
0.020622231,
0.0022824765,
0.017424481,
-0.0050315633,
0.009495363,
0.0052991305,
0.014448614,
0.0181815,
-0.011237811,
0.019317027,
-0.00093158975,
0.0027082993,
-0.037407164,
0.018768841,
-0.00036606909,
-0.023793878,
0.010134913,
-0.010833197,
-0.007361354,
-0.0006158934,
0.0002775599,
-0.0052730264,
-0.01557109,
0.0083598355,
-0.039834842,
-0.010794042,
-0.008555615,
-0.024968563,
0.030150225,
0.020087099,
-0.003462055,
-0.00874487,
0.0064542363,
-0.16163653,
0.022958549,
0.0042125476,
-0.023245692,
0.049023483,
0.01138791,
0.01557109,
0.012268922,
-0.01550583,
0.0050805085,
0.014827124,
-0.005383969,
-0.007126417,
-0.019356184,
0.0149445925,
-0.007145995,
-0.010395954,
0.03680677,
0.005746163,
0.020570023,
0.02884502,
-0.0019480177,
0.040356923,
-0.02500772,
0.03299557,
0.02374167,
0.011407488,
0.022436466,
0.017254803,
0.02469447,
-0.006323716,
-0.011107291,
0.048031528,
-0.006937162,
-0.0028355569,
-0.0252035,
0.0075636604,
-0.0022563722,
0.00085735624,
0.020831065,
0.0031096498,
0.017568054,
-0.0064020283,
-0.012438599,
-0.030202433,
0.022553934,
-0.007583238,
-0.04262798,
0.013952636,
0.0055438564,
0.023911348,
0.010702677,
0.028740603,
0.01844254,
0.008973281,
-0.0030623362,
-0.02431596,
0.0075375563,
-0.0038797206,
-0.009214744,
-0.0002753166,
-0.0045355856,
0.0070481044,
-0.0023314217,
0.030150225,
-0.027826961,
-0.016497785,
-0.02182302,
-0.008692662,
0.006663069,
-0.012895421,
-0.013495815,
0.0039025615,
0.0013468079,
0.00026348815,
0.0019953314,
-0.004013504,
-0.0029644459,
-0.00329401,
0.010670047,
-0.016158432,
-0.010611313,
-0.031194389,
-0.016171485,
-0.00344574,
0.002109537,
0.008470777,
0.0125886975,
-0.00040971185,
0.0076550245,
0.0070807347,
-0.01716344,
0.00013684254,
-0.005811423,
0.0016282427,
0.029732559,
-0.0017049235,
-0.004956514,
-0.02941931,
0.005227344,
0.009821665,
-0.0038927726,
-0.041531608,
-0.0135349715,
0.048892964,
-0.0058310013,
-0.004046134,
0.0027001419,
0.018964622,
-0.019186506,
0.026965525,
-0.006235615,
0.0047117886,
0.026835006,
-0.01996963,
0.01888631,
0.0055438564,
-0.019773848,
-0.021940488,
-0.00976293,
0.06024824,
0.00044009867,
-0.022762768,
0.015649403,
-0.02284108,
-0.020752752,
-0.13031162,
0.004636739,
-0.0004890438,
0.02456395,
0.019565016,
0.024067972,
-0.013495815,
0.009071171,
-0.010069653,
0.03777262,
-0.0011803943,
-0.018351177,
-0.015388361,
-0.00740051,
0.035971437,
0.00025818578,
-0.0128040565,
0.008020482,
-0.017724678,
0.030698411,
-0.009854294,
-0.016484734,
-0.0033217457,
-0.0055569084,
0.022253737,
-0.019003779,
-0.014670499,
0.017189544,
0.01330656,
0.045133974,
0.022893287,
0.008973281,
-0.0037883562,
-0.011590216,
-0.020765804,
-0.00007234708,
0.0510596,
-0.018325072,
0.028349042,
-0.02787917,
-0.004140761,
0.015662454,
0.018912414,
-0.021300938,
0.04377656,
-0.009012437,
-0.01773773,
0.012445126,
-0.015492778,
-0.020060994,
-0.020060994,
-0.015323102,
-0.038816784,
-0.008177106,
0.024107128,
0.003119439,
0.014004845,
-0.0024668365,
-0.050198168,
-0.014474719,
0.011955674,
0.011851258,
-0.019786902,
0.0064509735,
0.007909539,
-0.03153374,
-0.005641747,
-0.01493154,
0.026704485,
0.0013549655,
0.0030280745,
0.026443444,
-0.014187573,
-0.0033804798,
-0.023885243,
0.03432688,
-0.028427355,
-0.001669846,
0.023911348,
-0.017620262,
-0.01036985,
0.0021764287,
0.010552579,
-0.015140372,
-0.015832132,
0.020387296,
0.016132329,
0.011087713,
0.009919555,
-0.036832873,
0.0127649,
0.050511416,
0.00024615342,
-0.0059093134,
-0.011329176,
0.040095884,
-0.008725292,
0.009351791,
0.034692336,
0.0049108323,
-0.032316864,
-0.02858398,
-0.05544509,
0.020374242,
0.01397874,
-0.0071003125,
-0.0027654022,
-0.0131564615,
0.012914999,
0.006636965,
0.0025582009,
0.0065292856,
-0.011994829,
-0.0011314492,
-0.013254352,
0.013169514,
-0.024081023,
0.027226567,
0.022175426,
0.007713759,
0.02323264,
0.012921525,
0.005485122,
0.018768841,
-0.022867184,
0.016510837,
0.007172099,
0.0030492842,
0.00057306635,
0.00851646,
-0.0015287208,
-0.004835783,
0.015518882,
-0.024655314,
-0.028949438,
0.014553031,
-0.019813005,
-0.021092106,
-0.026887214,
0.0026479338,
0.008764449,
-0.00034078074,
-0.019029882,
0.0032320127,
0.0010490582,
0.010637417,
-0.0070350524,
0.017763834,
-0.037615996,
0.0063074008,
-0.010696151,
-0.012543016,
0.015936548,
0.013626335,
-0.0030623362,
-0.004029819,
-0.037746515,
0.003468581,
-0.023819983,
0.008137951,
-0.009854294,
-0.031925302,
-0.014644395,
-0.01888631,
-0.021209573,
0.00014377644,
-0.01263438,
-0.0028029268,
0.019734692,
-0.007172099,
0.026965525,
-0.010069653,
-0.04103563,
-0.0058897357,
0.005994152,
-0.013443607,
0.0015491146,
0.01340445,
0.001000113,
0.014513874,
0.008692662,
0.011877362,
-0.0022025327,
-0.03114218,
-0.02098769,
0.018103188,
0.019956578,
0.012667011,
0.011309598,
0.019512808,
0.003135754,
-0.004114657,
-0.007863858,
0.015662454,
0.011936096,
0.014331146,
-0.0047672596,
0.015270893,
-0.014109261,
0.0064803404,
-0.011374857,
0.00056083006,
0.0018289179,
0.023062965,
-0.008013956,
-0.026717536,
-0.012210188,
0.009534519,
-0.012797531,
-0.016471682,
-0.0026250926,
-0.0010360061,
0.02162724,
0.02162724,
0.0036088906,
0.005380706,
-0.008053112,
0.010154491,
0.003468581,
0.0111790765,
-0.0060985684,
0.037381057,
-0.019878265,
0.011890413,
0.029471518,
0.024394274,
0.026573965,
-0.004274545,
0.01588434,
-0.009704196,
0.027748648,
-0.013913481,
-0.013639388,
0.008692662,
-0.030489579,
-0.0016233481,
0.005795108,
-0.009430103,
0.025673373,
0.0038568794,
-0.0070154746,
0.08765753,
-0.016863242,
-0.038138077,
-0.023715567,
0.018077083,
0.010258907,
-0.016549993,
0.019356184,
0.0051294537,
-0.027017735,
0.00631719,
-0.01422673,
0.021079054,
-0.04683074,
-0.044376954,
0.005524278,
-0.0023248957,
0.018912414,
0.0006660622,
0.004326753,
0.010030497,
-0.00095279934,
-0.005184925,
0.0008075953,
-0.029706456,
-0.004375698,
0.023833035,
-0.024081023,
-0.0067413813,
-0.014474719,
-0.003439214,
0.026430393,
-0.028479563,
-0.013378346,
0.035579875,
-0.00043805927,
-0.005527541,
-0.00864698,
-0.003458792,
0.009201692,
-0.035423253,
0.033622067,
-0.00459432,
-0.022580039,
-0.0049238843,
-0.031246597,
-0.007700707,
-0.005641747,
-0.0083598355
] |
Adherens junctions and their core molecular components, classic cadherins, make major contributions to animal morphogenesis. Although the significance of cadherins in development is generally accepted, the mechanisms regulating adherens junction function during morphogenesis remain a subject of intense research. Adherens junctions are involved in the organization of simple cellular patterns, and more complex cell shape changes and cell movements that depend on the dynamic modulation of adherens junctions. | [
-0.0257413,
0.019778408,
0.020646667,
-0.0099722,
-0.016713968,
0.008197377,
-0.012672737,
-0.0040667676,
0.00059812446,
-0.017352393,
0.025192253,
0.0024020744,
0.0016838461,
0.013509074,
-0.022766238,
-0.005311697,
0.02666063,
-0.012130076,
-0.03503677,
0.020927574,
-0.0015481808,
0.012698275,
-0.022523636,
-0.029622924,
0.0003084391,
0.046885937,
0.013534611,
-0.01772268,
0.001222584,
-0.0199444,
0.018003587,
0.013738908,
-0.011753405,
-0.0010031253,
0.00001607285,
0.023736645,
0.016164923,
-0.008120767,
0.0033772686,
0.016037237,
0.015424349,
-0.0015920725,
-0.016943801,
-0.0061959154,
-0.029495237,
0.0029096222,
-0.0038273584,
-0.019395353,
-0.022370415,
0.03756493,
-0.005832013,
0.014990221,
-0.014709313,
-0.023557885,
-0.025766836,
-0.010795768,
-0.0009440711,
0.012474826,
0.016471367,
-0.018884614,
-0.01273658,
0.009186937,
-0.0056117564,
0.006869454,
-0.01857817,
0.013968741,
-0.0032783127,
0.0007030656,
0.022178886,
-0.0022552365,
0.025677456,
0.03876517,
0.010067963,
-0.0059756585,
0.0276055,
-0.0149519155,
-0.009072021,
-0.001019086,
-0.031589273,
0.02786087,
-0.024323994,
-0.0132792415,
0.011996007,
0.037947986,
0.003744363,
-0.008401674,
0.016726736,
-0.004631774,
-0.0014667816,
-0.009269932,
-0.01815681,
0.034704786,
0.0077824015,
0.005193588,
-0.014466712,
-0.003872048,
0.0036326386,
0.026916001,
0.004076344,
-0.006211876,
-0.010878763,
0.013726139,
-0.0036198702,
-0.01831003,
-0.0023270594,
-0.013164325,
0.011287355,
-0.0047849957,
0.028805738,
-0.0074504204,
-0.022625785,
0.033887602,
-0.005043558,
-0.040501688,
0.009793441,
-0.014134731,
0.024004783,
-0.0054010763,
0.010719157,
-0.010955374,
0.0060969596,
0.042033907,
0.019037835,
-0.01371337,
0.03337686,
0.025383782,
0.021259556,
0.025651919,
-0.022842849,
-0.014543323,
0.006116112,
-0.00911671,
0.027247982,
0.03738617,
0.009333774,
-0.006141649,
-0.010336102,
0.0012664758,
-0.00788455,
-0.022842849,
0.006058654,
0.023647264,
-0.020187,
0.003872048,
0.013266473,
0.012889802,
0.0199444,
0.0024323994,
0.018871846,
0.025345474,
0.01831003,
-0.00024838725,
0.03577734,
-0.0036007173,
0.0056436774,
0.028269462,
-0.018769696,
0.02548593,
-0.01611385,
0.014785925,
0.0013869784,
0.0126216635,
0.009691292,
-0.0047275377,
0.028422683,
0.019433659,
0.0053340415,
-0.006926912,
0.0100935,
-0.008944335,
-0.009091173,
0.01124905,
-0.015973395,
0.02471982,
-0.019906094,
-0.00097120414,
-0.0029399474,
0.021438314,
-0.029367553,
-0.028014092,
-0.012596127,
-0.0018833539,
0.015411581,
0.004076344,
-0.020135926,
-0.012034313,
0.019816713,
-0.0011643277,
-0.005573451,
-0.009282701,
-0.02547316,
0.008931567,
-0.008127151,
-0.009174168,
-0.6423067,
0.0007301987,
0.03141051,
-0.02658402,
0.008567665,
0.022983303,
0.014262416,
-0.0046988083,
-0.0033198104,
-0.0067673055,
-0.027963018,
0.015909553,
0.013598454,
-0.020148695,
-0.030389033,
-0.025524234,
-0.009206089,
-0.029725071,
0.03261075,
0.013994277,
-0.025179485,
0.0007066567,
0.0023797294,
0.018705854,
-0.00494141,
0.0022887539,
0.034883548,
0.0031234946,
0.021170175,
0.037641544,
-0.018718623,
0.00014983039,
-0.020250844,
0.00555749,
0.039429132,
0.013866592,
-0.025843447,
0.031129606,
0.01150442,
0.04458761,
-0.0100935,
-0.016024468,
0.0044689756,
0.020212539,
-0.020493444,
-0.011574646,
-0.0013430867,
-0.0011531552,
0.013445232,
0.004938218,
-0.014326259,
-0.016803348,
-0.042493574,
-0.014326259,
-0.0027851295,
-0.0121747665,
0.025422087,
-0.018182347,
0.0029942135,
0.0074504204,
0.01338139,
0.013777213,
-0.027375666,
-0.01874416,
0.0076355636,
0.008337831,
-0.018450484,
0.023481274,
-0.0032160664,
-0.015500961,
0.017505616,
0.031078532,
-0.00058136584,
0.0088868765,
-0.009333774,
0.028473757,
-0.0013367025,
0.015884016,
-0.016982106,
0.0070226756,
0.010578703,
0.0050722873,
-0.023953708,
0.011402272,
0.016343681,
-0.0048584146,
-0.016637357,
0.012928108,
0.006690695,
0.001324732,
0.0066332365,
-0.02019977,
-0.0076419483,
-0.052299783,
-0.027145835,
0.009614682,
-0.0050275973,
0.009072021,
0.0043859803,
-0.019471964,
-0.009212473,
-0.010170111,
-0.011536341,
-0.010744694,
0.018756928,
0.0048999125,
-0.028014092,
0.028729128,
0.0626678,
-0.049184266,
-0.015386044,
-0.00064560736,
-0.0076100267,
-0.012794038,
-0.020455139,
-0.02069774,
0.004200837,
0.0077121747,
0.00830591,
-0.04573677,
-0.0017093831,
-0.0093656955,
-0.0035209144,
-0.02078712,
0.035470895,
-0.02088927,
0.008612354,
-0.0385098,
-0.011913012,
-0.0023972862,
0.0102020325,
0.0036262544,
-0.0022344878,
-0.009308238,
-0.0076291794,
0.013700602,
-0.0060873833,
-0.0023765373,
0.0059756585,
-0.0037092497,
-0.0072397403,
0.0073865782,
0.0012002392,
-0.023915403,
-0.021285092,
-0.030184736,
-0.009946663,
0.008178225,
0.0021467044,
-0.005270199,
-0.019893326,
-0.00029407456,
-0.0052350857,
0.01371337,
0.0028952577,
-0.00029148094,
-0.018603707,
0.008695349,
0.014453944,
-0.015449886,
0.0012066234,
0.013406927,
-0.045889992,
0.0034762246,
-0.012340756,
0.0041114576,
-0.0075972583,
-0.00524147,
0.022051202,
-0.039939873,
-0.007405731,
-0.013687833,
-0.008382522,
-0.0017891863,
0.002312695,
0.021617074,
-0.012730196,
-0.017365161,
0.0019424083,
0.0024116507,
0.0054106526,
-0.016050005,
-0.008459132,
-0.02547316,
0.034653712,
0.003744363,
0.035138916,
0.009857283,
0.014581628,
0.028524833,
-0.0032910812,
0.028984498,
-0.022357646,
-0.0152200535,
0.006186339,
-0.032866124,
0.025281632,
0.015207285,
0.0023414239,
0.03427066,
0.013470769,
-0.011402272,
0.022613015,
0.005595796,
-0.00023741432,
0.004223182,
-0.0076738694,
-0.035292137,
0.0047466904,
0.025358243,
0.003900777,
0.0072716614,
0.0018562209,
-0.02514118,
0.02377495,
0.020135926,
-0.02054452,
0.01721194,
-0.029852755,
0.0058479737,
0.006792843,
0.0018881422,
0.038407654,
-0.011708716,
0.0008459132,
0.010119038,
0.0069971387,
0.0136367595,
-0.013432464,
-0.0013686237,
-0.023570653,
0.02120848,
-0.0055415295,
0.0004281438,
-0.018731391,
0.0059373532,
0.006722616,
-0.02002101,
0.014556091,
-0.0043604434,
0.027145835,
0.047422215,
-0.025549771,
0.014466712,
0.021540461,
-0.0097232135,
0.03296827,
0.01524559,
0.0033006575,
-0.008746424,
0.01610108,
0.016471367,
-0.003361308,
0.0004891932,
0.004711577,
-0.0046988083,
0.015462656,
0.029214332,
0.033325788,
0.0106808515,
-0.0025153947,
-0.018041892,
-0.009895588,
-0.0067673055,
0.009404001,
0.02471982,
0.013023871,
-0.021604305,
-0.011619336,
-0.006179955,
-0.012123692,
0.009040099,
-0.002165857,
-0.025332706,
0.009825362,
0.007686638,
0.0076738694,
0.007156745,
0.0028473758,
0.010565935,
0.008791113,
-0.026864927,
0.019714566,
0.012564206,
-0.0045008967,
-0.008714502,
-0.020684972,
0.007380194,
-0.010936221,
0.014785925,
0.0066332365,
0.0144156385,
-0.007833475,
-0.008746424,
0.0041018813,
0.009601913,
-0.0069141435,
-0.017518384,
0.02385156,
-0.013189862,
0.01781206,
0.005123361,
0.006170378,
-0.013866592,
0.029112183,
0.0155775715,
0.0035815646,
-0.022076739,
-0.016573515,
-0.041982833,
-0.04650288,
-0.0057426337,
-0.00851659,
-0.007265277,
-0.0071695135,
0.010304181,
0.004631774,
0.009684908,
0.051380448,
0.013330315,
-0.020135926,
-0.015028526,
0.013087714,
-0.017990818,
0.0294697,
0.0071695135,
0.00137421,
0.018910151,
-0.008293142,
-0.018667549,
-0.018910151,
0.0015346142,
0.012998334,
-0.015628645,
-0.010776615,
-0.011957701,
0.007009907,
-0.012302451,
0.008465516,
0.02844822,
-0.023608958,
-0.010106269,
0.024068626,
0.0007365829,
0.0057585943,
-0.018437715,
0.030772088,
0.034219585,
0.020238075,
0.0009735982,
-0.028218389,
0.043080922,
0.00024300054,
-0.026788317,
0.03033796,
0.024260152,
-0.02359619,
0.01755669,
-0.037641544,
-0.031129606,
0.0025297594,
0.032661825,
0.008248452,
0.010431865,
-0.0020732854,
0.009103942,
0.013062177,
-0.0134580005,
-0.0011116577,
-0.015820174,
0.0096338345,
-0.012851496,
0.010476556,
-0.0067353845,
0.0056149485,
-0.034372807,
0.011830017,
-0.013930435,
0.016279839,
0.018910151,
0.019957168,
-0.0031873372,
0.018961225,
-0.023136524,
-0.015947858,
-0.020506212,
-0.006894991,
-0.02844822,
-0.008216531,
-0.021285092,
-0.040527225,
-0.004871183,
-0.030184736,
0.0014212938,
-0.007980313,
-0.0294697,
-0.01516898,
-0.007437652,
0.016050005,
0.01380275,
0.022779007,
-0.0059469296,
0.0028042821,
0.03337686,
0.0015386044,
-0.028933425,
-0.020187,
-0.017543921,
-0.026098818,
-0.0024483602,
0.008076077,
-0.0037156339,
0.005624525,
-0.0076291794,
-0.003562412,
-0.012787654,
0.01839941,
0.005123361,
-0.0076036425,
-0.0034602638,
0.00788455,
0.018029124,
-0.0052191247,
-0.027452279,
-0.0044913203,
-0.038177818,
0.0008898049,
-0.02931648,
-0.0017429005,
0.006144841,
-0.003005386,
0.019561345,
-0.0276055,
0.007993082,
-0.009595529,
-0.026354186,
-0.013994277,
0.007993082,
0.0034411112,
0.025511466,
0.016484136,
0.015858479,
-0.006116112,
0.0063778665,
-0.008267605,
-0.0035177222,
0.026813854,
0.017646069,
-0.029520776,
-0.00071463705,
-0.011523573,
-0.008982641,
-0.03927591,
-0.024362301,
-0.013598454,
0.03253414,
0.0110383695,
-0.031052995,
0.007233356,
0.001605639,
0.008810266,
0.026303113,
-0.0099722,
0.0016343682,
-0.0066587734,
0.013164325,
0.015807405,
-0.03799906,
-0.0065310886,
-0.041344408,
-0.012104539,
0.017773753,
-0.0038050134,
0.009959431,
-0.015105138,
0.0021307436,
0.017531153,
-0.0011850765,
0.005710712,
-0.040859204,
-0.018705854,
0.007258893,
0.04251911,
0.043412905,
0.019727334,
-0.0019982704,
0.04116565,
-0.0030708245,
0.0096338345,
0.0051552826,
0.0023557886,
0.020953111,
-0.018220652,
0.037692618,
0.010955374,
0.020633899,
0.01942089,
0.0015154615,
0.031001922,
0.014875304,
-0.007693022,
-0.037513856,
0.0012114116,
-0.019548576,
-0.0259839,
0.017531153,
-0.00651832,
-0.016420294,
-0.05112508,
-0.009174168,
-0.009946663,
0.019829482,
-0.017365161,
-0.02189798,
-0.0007768835,
-0.0058958554,
0.01839941,
-0.013228168,
0.0014955107,
0.007954776,
-0.006186339,
-0.0026462718,
-0.010827689,
0.016650125,
-0.02335359,
0.011031985,
0.019663492,
-0.003208086,
-0.0010534014,
-0.016177692,
0.0009791844,
-0.031640347,
0.010578703,
-0.021119101,
-0.0045647393,
-0.016943801,
-0.008682581,
-0.02317483,
0.012149229,
0.0023956902,
-0.032687362,
0.019012298,
0.0070609814,
-0.010776615,
0.023340821,
0.0024276113,
0.01533497,
-0.0294697,
0.014007046,
0.0017668414,
-0.0073993467,
0.000637228,
-0.010042426,
-0.013751676,
0.013649528,
0.024732588,
-0.021234019,
0.0024371876,
-0.012755733,
-0.0036071017,
0.018514328,
-0.01968903,
-0.013853824,
0.005458534,
0.026992612,
-0.002036576,
0.0018642012,
-0.004692424,
-0.029520776,
0.0045264335,
-0.016062776,
-0.0066651576,
-0.011319277,
-0.0150796,
-0.00886134,
0.022727933,
-0.008018618,
0.03679882,
0.0058224364,
-0.02051898,
0.02131063,
-0.0112171285,
0.011855554,
0.01967626,
0.007954776,
0.0042391424,
-0.004919065,
0.009397617,
0.028805738,
0.023468506,
-0.012672737,
-0.0033676922,
-0.015462656,
0.039505742,
-0.016573515,
-0.014645471,
0.009870051,
0.012474826,
0.028141778,
-0.032406457,
0.00079563726,
-0.020608362,
-0.033530086,
-0.019203827,
0.013164325,
0.0065151276,
-0.0145943975,
-0.013004718,
-0.000534681,
0.0031665883,
-0.025383782,
-0.015552035,
-0.007667485,
-0.023787718,
-0.0046796557,
0.016177692,
0.013917667,
0.012079002,
-0.015858479,
-0.010936221,
-0.028014092,
0.022242729,
-0.003104342,
0.037616003,
0.0150796,
0.011274586,
-0.016982106,
0.0068119955,
-0.006894991,
-0.01770991,
0.0073482725,
-0.005477687,
-0.008644275,
0.010412713,
0.007814323,
0.010508477,
0.0050786715,
-0.01644583,
-0.004532818,
-0.0035049536,
0.02590729,
0.018297262,
-0.013777213,
0.014479481,
-0.02530717,
-0.00941677,
0.012417368,
-0.02548593,
-0.0074248835,
0.035905026,
-0.04142102,
0.0075781057,
-0.024349533,
-0.022357646,
-0.019548576,
0.017786523,
0.0018211075,
-0.003900777,
-0.00488076,
-0.017097024,
-0.015960626,
0.031640347,
-0.007890934,
-0.019025067,
-0.0126472,
-0.005350002,
0.0055798353,
0.038714096,
-0.018424947,
-0.018603707,
0.020991417,
-0.007801554,
-0.017926976,
0.0058926633,
-0.014134731,
0.024898577,
0.015437118,
-0.0064002112,
-0.0035496433,
-0.01257059,
-0.025409319,
-0.022357646,
0.016739504,
-0.004006117,
0.0040667676,
-0.0046509267,
0.012181151,
0.03603271,
0.0027835332,
0.0019551767,
0.013841055,
-0.0087081175,
0.007878166,
-0.025996668,
0.02309822,
-0.0025872176,
-0.037360635,
-0.024260152,
0.03700312,
-0.0118747065,
-0.00788455,
0.008012234,
-0.013406927,
0.0144156385,
-0.01848879,
0.023340821,
0.01287065,
0.0064576697,
0.055772815,
-0.016713968,
-0.008478285,
0.0037475552,
-0.019701798,
-0.006240605,
0.010470171,
-0.034398343,
0.020046547,
0.0057234806,
0.02051898,
-0.026137123,
0.0116959475,
-0.026635094,
0.0089187985,
0.0058926633,
-0.0057426337,
0.021540461,
0.016816117,
-0.012966413,
-0.010451019,
-0.016292607,
-0.020046547,
-0.01111498,
-0.005595796,
-0.02563915,
-0.010674467,
-0.010865995,
-0.0031969135,
-0.038126744,
0.014619934,
-0.0012808403,
0.0064576697,
-0.009557223,
0.006652389,
0.000636031,
0.0014795501,
0.004839262,
0.00519678,
-0.007003523,
-0.011453345,
0.008063309,
-0.011070291,
0.009518918,
-0.00064201624,
0.004050807,
-0.0099722,
0.0126216635,
-0.013113251,
-0.010278644,
-0.012244993,
-0.009908357,
0.17344733,
-0.016573515,
-0.006419364,
0.012960029,
0.0017939744,
-0.012257761,
0.0023813255,
0.006677926,
0.0021068028,
0.028167315,
0.013432464,
0.031972326,
-0.020582825,
-0.004660503,
0.037462782,
-0.02683939,
-0.024209078,
0.009806209,
-0.017735448,
0.014109194,
0.011906628,
-0.009844515,
0.01770991,
0.00504675,
0.024566596,
-0.022779007,
-0.025281632,
0.00010683644,
-0.005624525,
0.0028282232,
-0.018016355,
0.012347141,
-0.00081598706,
0.016164923,
0.012149229,
-0.0049318336,
-0.027477816,
0.008178225,
0.011830017,
-0.0023366357,
0.002569661,
-0.021119101,
0.0054361895,
0.016484136,
0.008637891,
0.009123094,
0.014696545,
-0.013049409,
-0.01952304,
0.010910684,
-0.029903831,
0.022255497,
0.000840327,
0.007954776,
-0.019408122,
-0.008791113,
0.008957104,
0.024758125,
0.011957701,
0.014683777,
-0.02632865,
-0.0014348603,
0.004711577,
0.016765043,
-0.022676859,
0.014492249,
-0.00941677,
0.013189862,
0.0059820428,
-0.027477816,
-0.0023877097,
-0.02062113,
-0.018705854,
0.0053085047,
-0.0013502691,
-0.029673997,
0.024502754,
0.02335359,
0.016994875,
0.0039039692,
0.035215527,
0.0012896187,
-0.019216595,
-0.002036576,
-0.0058192443,
-0.029290942,
0.024975188,
0.0061480333,
0.00032918793,
-0.004446631,
0.0041593392,
-0.030082589,
-0.008222915,
-0.0048935283,
0.019791177,
0.0030708245,
-0.0071375924,
0.0058447816,
-0.007258893,
0.0068183797,
-0.014402869,
0.066242985,
0.033427935,
0.011702332,
-0.014517786,
-0.011836401,
-0.005927777,
0.00004573717,
0.022600247,
-0.026175428,
0.002470705,
-0.0008167851,
-0.009167784,
-0.0033421551,
-0.001886546,
-0.0016918264,
0.026864927,
-0.024707051,
0.038560875,
-0.024758125,
-0.0054713027,
-0.023583421,
-0.003540067,
0.04216159,
-0.00032180615,
0.0063842507,
-0.0102914125,
0.006831148,
0.010655315,
-0.03756493,
-0.005675599,
0.0017684374,
-0.02044237,
-0.014581628,
0.0018897383,
-0.010687236,
0.0028824892,
-0.010534014,
0.0033772686,
0.012742965,
-0.034628175,
0.0033325788,
0.031844642,
0.018437715,
0.012794038,
-0.003846511,
0.022600247,
0.025600845,
-0.023723876,
-0.009991352,
-0.019433659,
0.0068183797,
0.009959431,
-0.009059251,
0.018463252,
-0.019382585,
-0.02571576,
-0.025856216,
0.03756493,
-0.018552633,
-0.0352666,
0.006061846,
0.005828821,
-0.012238609,
0.005701136,
-0.017697142,
-0.15710364,
0.010751078,
0.028678054,
-0.01141504,
0.002315887,
-0.0011826825,
-0.01273658,
0.014083657,
-0.006444901,
-0.005477687,
0.04634966,
-0.004692424,
-0.039148226,
-0.02308545,
-0.0034921851,
0.005605372,
0.010674467,
0.012066234,
-0.014785925,
0.030057052,
0.02071051,
-0.021591537,
0.015194517,
-0.010942605,
0.010074347,
0.021272324,
0.020404065,
-0.013368621,
-0.01094899,
-0.024106931,
0.01473485,
-0.0076036425,
0.015386044,
-0.0018242997,
0.0006539867,
0.0065630097,
-0.025664687,
-0.01524559,
0.0035783725,
0.016037237,
0.024285689,
0.019612418,
-0.0072716614,
-0.00534681,
0.005448958,
0.017365161,
-0.01465824,
0.0012864266,
0.024732588,
-0.034321733,
0.022395952,
-0.01874416,
-0.003307042,
0.031819105,
0.042493574,
0.015922321,
0.005959698,
0.03748832,
0.005854358,
-0.008133535,
0.000509144,
-0.012251377,
0.04369381,
0.02198736,
0.0032783127,
-0.0149519155,
-0.015181748,
0.014849767,
-0.033887602,
0.021655379,
-0.008178225,
0.00082436635,
0.019114446,
-0.033632234,
0.013534611,
0.038816243,
-0.005094632,
0.0034794167,
-0.026890464,
-0.022523636,
-0.024132468,
0.0218086,
-0.020557288,
-0.0058639343,
-0.009729598,
-0.008159072,
0.006894991,
0.0027069224,
0.011012833,
0.023532348,
0.009206089,
-0.029214332,
-0.0021754333,
-0.020850962,
0.027707648,
0.026609557,
0.0014045351,
-0.024502754,
-0.0012377466,
0.011102212,
0.043183073,
-0.001373412,
0.0099722,
0.014377332,
0.019152751,
-0.0024770892,
0.012161997,
0.006183147,
0.05097186,
-0.0039199297,
-0.0064097876,
0.003005386,
-0.0034283425,
0.016943801,
-0.006186339,
0.047447752,
0.01917829,
0.0031554159,
0.0057266727,
-0.009065636,
0.068490244,
0.009512533,
0.00012928108,
0.008312294,
-0.019037835,
-0.026737241,
-0.13299671,
-0.0194975,
0.010546782,
0.03118068,
-0.008229299,
-0.003051672,
-0.0037826686,
0.041676387,
-0.024911346,
0.02317483,
-0.0385098,
-0.018808002,
0.00040180876,
-0.032508604,
-0.00902733,
0.013470769,
0.01060424,
-0.005780939,
-0.021412777,
-0.0021227633,
-0.008388906,
-0.023902634,
-0.010776615,
0.000280109,
0.0022680052,
-0.0008331447,
-0.038177818,
0.0023781334,
0.009557223,
0.018527096,
-0.0051105926,
0.0014404466,
-0.0043668277,
-0.022051202,
0.006435325,
-0.020902038,
0.0038624716,
-0.0059692743,
0.034321733,
-0.009601913,
0.004839262,
0.013994277,
0.01934428,
-0.010521245,
-0.0042678714,
-0.021068027,
-0.017735448,
0.002976657,
0.0023972862,
-0.006144841,
-0.023532348,
-0.010406328,
0.0013055793,
-0.024311226,
0.03350455,
-0.025128411,
-0.01248121,
0.016509673,
0.001043825,
0.01984225,
-0.011095827,
0.0047913804,
-0.012768501,
0.0029686766,
0.040450614,
-0.00967214,
-0.047217917,
-0.01048294,
0.03434727,
-0.022102276,
0.023660034,
0.0049861,
-0.009225242,
-0.0010526034,
-0.013789982,
0.0008866128,
-0.026379723,
-0.010476556,
-0.013866592,
-0.029725071,
0.012730196,
-0.019727334,
-0.0022281036,
0.0053595784,
0.045200493,
-0.0011092635,
0.00092172617,
-0.021834137,
0.016816117,
-0.013049409,
0.0030788048,
0.03414297,
0.027273519,
0.0073418883,
-0.0021099949,
0.019382585,
-0.011261818,
-0.0027675726,
0.003562412,
0.022344878,
-0.040348463,
0.01422411,
-0.043438442,
0.012953645,
0.002979849,
0.004915873,
0.01235991,
-0.025013493,
0.018029124,
-0.025830679,
0.0049031046,
0.005024405,
-0.009857283,
0.014083657,
-0.007226972,
-0.010706388,
-0.035164453,
-0.010744694,
0.040246315,
-0.0087081175,
0.0035049536,
0.027758721,
0.02335359,
-0.010489324,
0.015117906,
0.005576643,
-0.016905496,
-0.0072014346,
-0.011095827,
-0.010087116,
-0.013662296,
0.015437118,
0.0068630697,
-0.03639023,
-0.0014029391,
0.009091173,
-0.017148098,
-0.0028106663,
0.01018288,
0.016841654,
0.012851496,
0.042800017,
0.004874375,
-0.017863134,
0.0038209741,
-0.011791711,
-0.0032559677,
-0.0073546567,
-0.03996541,
0.0043189456,
0.001501097,
-0.025102874,
0.018986762,
0.008810266,
0.00078246975,
-0.026711704,
0.0057426337,
-0.0035304907,
0.013419695,
-0.012104539,
-0.0013710179,
-0.04864799,
0.034040824,
0.023864329,
0.004197645,
-0.011485267,
0.005014829,
-0.020825425,
-0.029367553,
0.003002194,
-0.008848571,
-0.024145236,
-0.025754068,
-0.0017907823,
0.013113251,
0.0023525965,
-0.01728855,
0.022204423,
-0.023442969,
0.004002925,
-0.012430136,
0.013330315,
0.008235684,
-0.006690695,
-0.014505018,
0.019408122,
0.02291946,
-0.010495708,
0.0002753208,
0.021872442,
-0.007686638,
0.010763846,
-0.01064893,
0.031027459,
0.019459195,
-0.00058535597,
-0.018935688,
0.022102276,
-0.0155775715,
0.037718154,
-0.018718623,
0.0052287015,
0.0012760521,
0.010463787,
-0.00018514328,
-0.0054042684,
-0.03723295,
0.019535808,
-0.0017397084,
-0.040425077,
-0.014888072,
0.0065630097,
0.028090702,
0.0054010763,
0.014836999,
-0.014364564,
0.002797898,
-0.0033549238,
0.03868856,
-0.003157012,
0.0024675129,
0.024732588,
0.013930435,
0.0087974975,
-0.016854422,
-0.007558953,
0.024579365,
0.009659371,
-0.00076531206,
-0.014607166,
0.0053085047,
0.0017173635,
0.015871247,
-0.020225307,
-0.0023047144,
0.0082612205,
-0.02027638,
-0.008669812,
-0.0023893057,
0.018476022,
-0.018220652,
0.080696926,
0.005966082,
-0.0118747065,
0.0068056113,
-0.023877097,
0.04234035,
0.0067800744,
0.009767904,
-0.020135926,
-0.028805738,
0.009646603,
-0.0067353845,
-0.0011419829,
-0.016599052,
-0.00519678,
0.015832942,
-0.018131273,
0.015922321,
-0.0036964812,
-0.012851496,
0.0009847707,
-0.021425545,
-0.02888235,
0.0061480333,
-0.0141475,
-0.013841055,
-0.010087116,
0.0042870245,
-0.021246787,
0.0001857418,
-0.00188495,
-0.0046190056,
-0.033683307,
-0.006170378,
-0.0017237477,
0.007412115,
-0.006282103,
-0.017441774,
-0.005573451,
0.01907614,
-0.0036613678,
0.0076100267,
-0.026941538,
-0.030899772,
-0.023289746,
0.02496242,
-0.018041892,
-0.020838194,
-0.010425481
] |
Publisher Summary This chapter discusses the developmental roles of vascular endothelial growth factor (VEGF) in skeletal morphogenesis, speculates on the future directions of research in this area, and describes some of the challenges in the field. VEGF regulates osteoclastic differentiation, migration, and activity. VEGF is, therefore, a key coordinator of the entire process. VEGF is necessary for osteoclastic activity both at the stage when the primary ossification center is established and later during bone growth. A number of studies have led to the identification of VEGF as a critical factor for the survival of chondrocytes | [
-0.019967355,
-0.028998664,
0.00027271282,
-0.019902568,
-0.01829585,
0.01924174,
-0.035814255,
-0.00037920644,
-0.023504727,
-0.022494048,
0.016209709,
-0.003125973,
0.013138805,
0.0012228547,
-0.0222349,
-0.021353798,
0.03485541,
-0.008720331,
-0.00802711,
0.016637303,
0.0014236944,
0.027003225,
0.012458541,
-0.0337929,
-0.02058931,
0.03394839,
-0.0039617256,
-0.039831053,
0.0017670656,
-0.02323262,
0.00022857665,
0.0105602825,
0.012432626,
0.0029008382,
0.0042921393,
0.0060770214,
0.008642587,
-0.019630464,
0.014654821,
0.0071265707,
0.025007784,
0.0021298728,
-0.012717689,
-0.012620509,
0.0065337694,
0.011182237,
0.014693693,
-0.028506283,
-0.023815705,
0.033585586,
0.009206234,
0.022532921,
-0.0064041954,
0.0057530864,
-0.01116928,
0.014266099,
-0.00087057543,
0.00867498,
0.011253503,
-0.030009342,
-0.02128901,
0.0065532057,
-0.01376076,
-0.0005304436,
-0.016261538,
0.01820515,
-0.017375875,
0.014836225,
0.023025302,
-0.009899454,
0.029335557,
0.027340116,
-0.011648703,
0.0018026985,
0.006925731,
-0.025007784,
-0.020200588,
-0.0002229078,
-0.034518518,
-0.004596638,
-0.006349127,
-0.025046656,
-0.008130769,
0.032341674,
0.019228784,
0.0059247715,
0.0014269338,
0.019798908,
0.0011110972,
0.00907666,
0.015263819,
0.0047002975,
0.01684462,
0.01510833,
-0.014149482,
-0.007884579,
0.018917806,
0.024955954,
0.018710487,
-0.018140363,
-0.0040945387,
-0.004246788,
-0.00088596233,
-0.014771437,
-0.03993471,
0.003624833,
0.0045998776,
-0.0052671838,
0.03306729,
-0.012400233,
-0.024852296,
0.040712155,
0.005898857,
-0.0041949586,
0.028895006,
-0.014952841,
0.042759426,
0.006666583,
0.0019533283,
0.012108692,
0.019163996,
0.0033980785,
0.011888416,
-0.028739516,
0.03026849,
-0.004658186,
0.01959159,
0.018878933,
-0.025461294,
-0.010061422,
0.008182599,
0.0024894408,
0.0096986145,
-0.0022157156,
-0.047735065,
-0.00090863777,
-0.02886909,
-0.0053190133,
-0.009795795,
-0.04561005,
-0.010761122,
0.020978034,
-0.0393905,
-0.00076003256,
-0.02752152,
0.008778639,
0.017894171,
0.019021465,
0.032367587,
-0.0049594454,
0.0050598653,
-0.010774079,
0.016248582,
-0.007748526,
0.002473244,
-0.014732566,
-0.001720095,
0.031486485,
-0.0025623261,
-0.012490935,
0.01734996,
-0.015095373,
0.020369034,
0.0036118757,
0.016974196,
0.0068933377,
-0.000031659587,
-0.018062618,
0.014667778,
-0.019798908,
-0.011266461,
0.035995662,
-0.0502488,
0.02128901,
-0.0094394665,
0.0007239948,
-0.008331609,
0.011946724,
-0.034388945,
-0.007340368,
-0.009854103,
-0.0052153543,
0.018464297,
-0.0078521855,
-0.018542042,
-0.003504977,
0.035477366,
-0.018451339,
-0.0034434295,
-0.022519963,
0.004327772,
0.0060705426,
0.0070034754,
-0.015276777,
-0.6364676,
-0.022299688,
0.008960043,
-0.0132619,
0.03400022,
0.025551995,
-0.002024594,
-0.013132326,
0.002657887,
0.010087337,
-0.023349237,
0.0379911,
-0.011642225,
-0.021548158,
-0.01929357,
-0.025746357,
-0.008973001,
-0.039675564,
0.028532198,
0.0010940905,
-0.013916249,
0.0024975392,
-0.0073857186,
0.025357634,
-0.004901137,
0.03107185,
0.034388945,
-0.014628906,
0.020628182,
0.029439216,
-0.009627349,
0.016922366,
-0.025215102,
0.029594705,
0.045299076,
0.009394116,
-0.013773718,
0.0042856606,
-0.0076707816,
0.053177174,
-0.027236458,
0.007249666,
0.023621343,
-0.0094912965,
-0.021185352,
0.010307613,
0.032548994,
-0.0032927997,
-0.005140849,
-0.0049691633,
-0.005966883,
-0.0051926784,
-0.011674618,
-0.0038807418,
-0.001426124,
-0.011998554,
0.010054943,
-0.005364364,
0.0031729436,
0.0071071344,
0.014343843,
0.035321876,
-0.016417028,
-0.021314925,
0.013981036,
0.022947557,
-0.0046452284,
0.008331609,
0.025305804,
0.005393518,
0.024761595,
0.018062618,
0.001326514,
-0.014304971,
0.025914803,
0.029853852,
0.003271744,
0.020304248,
-0.0037025774,
0.008078939,
-0.006990518,
0.0058599846,
-0.009070181,
0.03565877,
0.012827828,
0.00011681907,
-0.0537473,
-0.004133411,
0.011259981,
0.0071978364,
0.009743966,
0.0069127735,
-0.03954599,
-0.060847957,
-0.019423144,
0.043951504,
0.011259981,
0.04094539,
0.019850738,
-0.036669444,
-0.026847735,
0.019332442,
-0.004726212,
0.0019517086,
0.002058607,
0.02741786,
-0.04187832,
-0.009607913,
0.022869814,
-0.03646213,
0.011149844,
-0.01142195,
-0.016170837,
-0.00523479,
-0.0120439045,
-0.022131242,
0.0008422311,
-0.0064333496,
0.003051468,
-0.015613669,
0.009160883,
-0.017479535,
0.00022837419,
-0.008156684,
0.02099099,
-0.005639709,
-0.018503169,
-0.007210794,
-0.021742519,
-0.012108692,
-0.0004397418,
-0.002312896,
0.018308807,
-0.036228895,
0.03091636,
0.0037220134,
0.00847414,
0.005205636,
-0.009063702,
-0.018321766,
-0.0109749185,
-0.0038386302,
0.016585473,
-0.024722721,
-0.0157562,
-0.0081631625,
0.0029267531,
0.0032927997,
-0.0014706651,
0.02014876,
-0.013942163,
-0.01874936,
-0.020680012,
-0.005659145,
0.01096844,
-0.013294294,
-0.0010430708,
-0.010592676,
0.001371055,
-0.019280612,
-0.011046184,
-0.0010876119,
-0.03394839,
0.012179958,
-0.009666221,
-0.010884217,
-0.039831053,
-0.008299216,
0.0067767208,
-0.028480368,
-0.01605422,
-0.0105602825,
-0.013644144,
0.0072885384,
-0.010178039,
0.00872681,
-0.0047359304,
-0.0057919584,
0.0023760635,
-0.0046387496,
-0.00024153406,
-0.034622177,
0.0031340714,
0.004311575,
0.030683126,
0.023517683,
0.023932321,
0.023997108,
0.030138915,
0.019125124,
0.0055328105,
0.023465853,
-0.04208564,
0.022558836,
0.0043957983,
-0.07007363,
0.0042208736,
0.01111745,
-0.00024862014,
0.029180069,
0.043407295,
-0.02128901,
0.008506534,
0.023750916,
0.02188505,
0.0019355118,
-0.022584751,
-0.007359804,
0.005558725,
0.009141447,
0.009445946,
0.0076772603,
-0.0069581247,
-0.0008487098,
0.024878211,
-0.015833944,
-0.005675342,
-0.010463102,
-0.023841618,
-0.020317206,
-0.0024116964,
-0.03384473,
0.021055777,
-0.0015346422,
-0.016365198,
0.022144198,
-0.0037317316,
-0.0059701228,
0.0053449282,
-0.018321766,
-0.016339283,
0.030683126,
-0.00006736836,
-0.011408992,
0.01017156,
0.028091647,
0.010145646,
-0.019267656,
0.011849543,
0.00015346422,
0.023090089,
0.017440662,
0.014693693,
0.018451339,
-0.0034466689,
0.0011758842,
0.023154875,
-0.013080496,
-0.029594705,
0.01376076,
0.023012346,
0.0017103769,
0.00618392,
-0.017440662,
0.0108971745,
0.014136525,
-0.0053967577,
-0.0010625069,
0.017881215,
0.017479535,
0.019954398,
-0.002089381,
-0.010748165,
-0.0060057556,
0.007690218,
0.037420973,
-0.009646785,
0.0039260928,
-0.034259368,
-0.01953976,
-0.0067637637,
0.00025125212,
-0.0011993694,
-0.011532087,
0.011558002,
0.00079364085,
0.012393754,
-0.0037284922,
-0.004622553,
0.01440863,
0.020122845,
-0.02827305,
0.012737125,
0.015082415,
-0.010812951,
0.02009693,
0.0020197348,
0.0019176954,
-0.004463825,
0.012847263,
0.015872817,
-0.003411036,
-0.013158241,
-0.021081692,
-0.016689133,
0.005523092,
0.0063847597,
-0.009964242,
0.013333166,
-0.0032101963,
0.0031875207,
-0.0025250735,
0.006854465,
-0.006161244,
0.037965186,
0.010216911,
0.00009520653,
0.0037706038,
-0.016365198,
-0.0033073768,
-0.024567233,
0.006540248,
0.002363106,
-0.023945278,
-0.011946724,
0.0037608857,
0.023439938,
-0.007949365,
0.036980424,
-0.012484456,
0.001276304,
-0.024321042,
0.0019824824,
-0.022675453,
0.039520074,
0.020913245,
0.009543126,
0.02508553,
0.00752825,
-0.015237904,
-0.02562974,
-0.0060996967,
0.013734845,
-0.02288277,
0.008208514,
-0.015030585,
0.009588477,
0.0015540783,
0.014888054,
0.026135078,
-0.008519491,
-0.0032458291,
-0.007249666,
-0.019526804,
0.0019760036,
0.0013580977,
0.027055055,
0.04107496,
0.022118283,
0.016248582,
-0.011098014,
0.019630464,
0.0069322097,
-0.0068091145,
-0.0106380265,
0.030009342,
0.009147925,
0.01231601,
-0.004820153,
-0.029879767,
-0.0068285507,
-0.0032296323,
0.0021606467,
0.04123045,
0.010527888,
0.012853743,
-0.0020537481,
-0.00847414,
-0.0019581872,
-0.023725001,
0.010178039,
-0.0025283128,
0.0046646646,
-0.016326325,
-0.0020213546,
-0.010210432,
-0.009633828,
-0.018516127,
0.0053384495,
0.0136830155,
0.008500055,
0.0073921974,
-0.004781281,
-0.02188505,
-0.013106411,
-0.01775164,
-0.012296574,
-0.027236458,
0.0049594454,
0.0071589644,
-0.0093617225,
-0.009964242,
0.0019954399,
-0.006326451,
0.0041366504,
-0.009996635,
-0.03285997,
-0.013670058,
0.017090812,
0.01969525,
0.019176954,
-0.0133202085,
0.0033754031,
-0.0026433098,
0.0050987373,
-0.008934128,
-0.023426982,
-0.019176954,
-0.029776108,
-0.0058275913,
0.0019225545,
-0.0071524857,
0.00044298117,
-0.0011313431,
0.02428217,
0.018788232,
0.008500055,
-0.021859135,
0.0071006557,
-0.012944444,
0.014901011,
0.0029883008,
0.011901373,
-0.012503892,
-0.021923924,
-0.019915527,
-0.010799994,
-0.034881324,
-0.021651817,
0.0016156259,
-0.006313494,
0.0120698195,
-0.014486374,
0.0005676962,
0.0073533254,
-0.018010788,
0.009854103,
-0.0078521855,
0.00628434,
0.0120179895,
0.022545878,
0.0132165495,
0.021314925,
-0.007936409,
0.014317929,
0.0016391113,
0.022221943,
-0.014615948,
-0.024917083,
0.021224223,
0.019578634,
-0.0054680235,
-0.023776831,
0.022597708,
0.006413914,
0.03184929,
0.0040038372,
-0.011039706,
-0.020071015,
-0.01510833,
-0.008687938,
0.0011329628,
-0.010553803,
-0.00976988,
-0.001560557,
0.015419307,
0.023439938,
-0.026135078,
0.037213657,
-0.037006337,
-0.0024295128,
0.0005041239,
0.008888777,
-0.0025590868,
-0.030631296,
0.006951646,
0.0057628043,
-0.024826381,
-0.030009342,
-0.038068846,
-0.027702924,
-0.025824102,
0.029698364,
0.026303524,
0.028946834,
-0.015885774,
0.007573601,
0.0044055167,
0.00847414,
0.008584279,
-0.015924646,
0.01551001,
-0.030372148,
0.044366144,
0.010877739,
0.00907666,
0.03625481,
-0.019669335,
0.017686853,
0.032445334,
-0.00872681,
-0.0023145159,
0.0040556667,
-0.02277911,
-0.02876543,
0.02682182,
-0.018010788,
-0.00069119636,
-0.02632944,
0.005723932,
0.028739516,
0.011875458,
0.0039811614,
-0.013384996,
-0.0037317316,
-0.005539289,
0.012918529,
-0.004940009,
-0.0055068955,
-0.013734845,
0.0036863806,
-0.0033883604,
-0.018827105,
0.013670058,
0.008662023,
0.021314925,
0.017414747,
-0.014551162,
-0.010372399,
0.008687938,
-0.014564119,
0.0049594454,
-0.0038191942,
-0.029439216,
-0.0007454555,
-0.010514931,
-0.0037284922,
-0.035684682,
-0.00862315,
0.003715535,
-0.030786786,
0.022377431,
0.0027664052,
-0.004207916,
0.021055777,
-0.005205636,
0.01635224,
-0.019772995,
0.032238014,
0.0034661049,
0.014434545,
-0.021522244,
-0.003679902,
-0.00104712,
0.0010681758,
0.01684462,
-0.0052509867,
0.005808155,
-0.024463573,
0.00010578503,
0.0064592646,
-0.021742519,
-0.037369147,
0.016248582,
-0.0014018288,
-0.015315648,
0.008811033,
-0.004661425,
-0.01705194,
0.0107676005,
0.015445222,
0.006666583,
-0.0028538676,
-0.016015349,
-0.012134606,
0.015717328,
-0.0067896782,
0.019215826,
0.027340116,
-0.0015581275,
-0.021353798,
0.0108453445,
-0.006213074,
0.024334,
-0.00031381205,
0.027288288,
-0.008882299,
0.009756924,
0.022247858,
0.01694828,
0.0021023385,
-0.014965799,
-0.0051894393,
0.03609932,
0.0011945105,
-0.0074764206,
0.013527527,
-0.007243187,
0.009614392,
-0.01694828,
-0.0069386885,
-0.015782114,
-0.019824823,
-0.0068933377,
0.02702914,
-0.002437611,
-0.017790511,
0.00041301717,
-0.0062292707,
-0.018671615,
-0.0018658658,
-0.014654821,
-0.0070423475,
-0.031641975,
-0.009147925,
0.0020764235,
0.027987987,
0.016572516,
-0.01640407,
-0.00056526664,
-0.0015589374,
0.01685758,
-0.010035507,
0.030760871,
0.035244133,
0.009854103,
-0.02398415,
-0.0058535063,
-0.017725725,
-0.04117862,
0.0020262136,
-0.0032587864,
-0.025655655,
0.014084695,
-0.006886859,
0.018334722,
-0.017116727,
-0.030553553,
-0.015043543,
-0.010378879,
0.030579466,
0.011039706,
0.0012868319,
0.017881215,
0.013054582,
-0.013825547,
0.019954398,
-0.035581023,
-0.009905933,
0.021703647,
-0.012374318,
-0.0015143963,
0.0015062978,
0.0047359304,
-0.023362195,
0.0121734785,
0.00065637333,
-0.010961962,
-0.010417751,
-0.008759203,
-0.008065983,
0.008253865,
0.0059798406,
-0.026614502,
-0.0018107968,
0.009808753,
-0.0047845202,
0.0017330524,
-0.011305333,
-0.004593399,
0.0038483483,
-0.037783783,
-0.035036813,
0.004366644,
-0.029283727,
0.032548994,
0.020654097,
0.000912687,
-0.0131128905,
-0.014006951,
-0.05284028,
-0.022377431,
0.015535925,
0.015095373,
0.009186798,
-0.0067184125,
0.0010430708,
0.021159437,
-0.013035146,
0.022908686,
0.005814634,
-0.011713491,
0.0016634064,
0.010476059,
0.014512289,
0.015017628,
-0.019902568,
-0.019474974,
0.025850015,
-0.0019808628,
-0.014421588,
0.010955483,
-0.011603353,
0.029465131,
-0.00673137,
0.009348765,
0.013002752,
0.02967245,
0.02053748,
-0.050922588,
-0.015587754,
0.0032425898,
-0.0040038372,
-0.004651707,
0.008895256,
-0.01650773,
-0.008415832,
0.02044678,
0.0092839785,
0.009705094,
0.007366283,
-0.00060697325,
0.01700011,
0.03475175,
0.012821348,
0.027702924,
0.023569513,
0.020278333,
0.0064851795,
0.013786675,
-0.012361361,
0.014253141,
-0.017272215,
0.016274497,
-0.0040977784,
-0.005354646,
-0.00077865884,
-0.023595428,
0.0034207539,
0.008344566,
0.0017022786,
-0.006028431,
0.009316372,
-0.014615948,
0.008564842,
0.0032004782,
0.0014577076,
-0.020200588,
-0.049082637,
-0.009109053,
-0.025215102,
0.007495857,
-0.035736512,
0.0011758842,
-0.0045091757,
0.010586197,
0.0150565,
-0.024878211,
-0.020965075,
0.024424702,
0.18047069,
-0.005804916,
-0.018827105,
0.008921171,
0.003286321,
-0.025396507,
0.020161716,
-0.0076966966,
0.015795073,
0.0067378487,
0.014188355,
0.014149482,
-0.007359804,
-0.0008446606,
0.023608385,
-0.029750193,
-0.015937604,
0.0064398283,
0.005620273,
-0.021587031,
0.012912051,
-0.021794349,
0.015160159,
-0.007437548,
0.040712155,
0.0011297234,
-0.012944444,
0.026238738,
0.012743604,
0.0021800827,
-0.003296039,
0.0058858995,
-0.0017184754,
0.010301134,
-0.0020035382,
0.0015233045,
0.0037900398,
-0.016028306,
0.0005830831,
0.009588477,
0.0058891387,
0.015367478,
-0.015030585,
0.0002154168,
0.02058931,
0.031771548,
-0.0092580635,
0.010327049,
-0.032393504,
-0.010352964,
-0.04742409,
0.008104854,
0.00997072,
0.015717328,
-0.015341563,
0.004282421,
0.035995662,
0.014719608,
0.0025218343,
0.008487098,
-0.024644976,
-0.0014973897,
-0.030320318,
-0.016870536,
-0.011506173,
0.011590395,
-0.010696335,
-0.02055044,
-0.00045836807,
-0.00822795,
0.010825909,
0.008150205,
-0.008221471,
0.0133720385,
-0.010553803,
-0.028117562,
-0.0049043763,
-0.003744689,
-0.0070876987,
0.016235624,
-0.0037868004,
0.010890696,
-0.013540484,
-0.007618952,
-0.009776359,
-0.031356912,
0.018114448,
0.010903653,
-0.010216911,
-0.018360637,
0.0054777414,
-0.018930763,
-0.0193454,
0.014019908,
0.028946834,
-0.0040070764,
-0.008584279,
0.040012456,
0.0016383014,
0.0053028166,
-0.021250138,
0.07883283,
0.013695973,
-0.0002583382,
0.008240907,
0.017958958,
-0.019436102,
0.014136525,
-0.033637416,
-0.0071330494,
-0.0010730348,
0.006219553,
0.0034142754,
-0.0056947777,
-0.007560644,
0.011156322,
0.016792793,
-0.027236458,
0.038379822,
-0.022545878,
-0.017829385,
-0.019487932,
0.008551884,
0.030553553,
-0.014901011,
-0.009886498,
-0.026057335,
0.012154043,
-0.013035146,
-0.031097762,
-0.010145646,
0.0019095971,
-0.007683739,
0.01481031,
0.013397953,
-0.011026748,
0.0048298715,
0.0050274716,
-0.00051586656,
0.014991714,
-0.023699086,
-0.008694416,
0.03021666,
0.024644976,
0.011506173,
-0.014369758,
0.007904015,
-0.0037284922,
-0.021535201,
-0.023504727,
-0.029024579,
-0.013255422,
0.003346249,
-0.007845706,
0.004943249,
-0.020032143,
-0.0023193748,
-0.044236567,
0.025772272,
-0.0065694023,
-0.009115532,
0.014136525,
0.010443665,
-0.032523077,
0.004363405,
-0.018503169,
-0.16046445,
-0.006323212,
0.018451339,
-0.04561005,
0.0108971745,
0.009057224,
0.004246788,
-0.0006308635,
-0.018969636,
0.011551524,
0.054783892,
0.011875458,
-0.04102313,
-0.026264653,
0.007275581,
0.00892765,
-0.0028814021,
0.010676899,
-0.0014892913,
0.022416305,
0.03366333,
-0.0067184125,
0.022519963,
-0.012076298,
0.009944806,
0.0061256113,
0.021301968,
-0.011486736,
-0.016417028,
-0.0070229117,
-0.019060338,
0.0057660434,
0.021198308,
0.00009196718,
-0.0045739627,
0.0014779536,
0.019060338,
-0.0015322127,
0.0071265707,
0.021107607,
0.02642014,
0.014421588,
-0.015302691,
-0.0032685045,
-0.0046063564,
0.024346957,
-0.022092368,
-0.012290095,
0.03809476,
-0.026096206,
0.03638438,
-0.00089325086,
-0.012192914,
0.017505448,
0.00842231,
0.011687576,
-0.004778042,
0.01740179,
0.0042273523,
-0.028661773,
-0.008169642,
-0.00912201,
0.0063944776,
0.0034725836,
-0.010903653,
-0.023543598,
-0.013138805,
0.020524524,
-0.032885883,
-0.006436589,
-0.01994144,
-0.0061256113,
0.008117812,
0.007573601,
0.027599264,
0.015587754,
-0.011946724,
0.012899093,
-0.0044541066,
0.016287453,
0.0053384495,
0.0027064772,
-0.014019908,
-0.0050922586,
-0.004778042,
0.019397229,
0.014719608,
0.010877739,
0.016961237,
0.0026611262,
0.010365921,
-0.029257812,
-0.0080076745,
-0.0035373706,
0.029076409,
0.015445222,
0.0031518878,
-0.02417851,
-0.010754643,
0.0094135525,
0.043640528,
-0.011363641,
-0.019112168,
0.014628906,
0.020317206,
0.005101977,
0.0038386302,
0.029931597,
0.045065843,
-0.0083186515,
-0.0043407297,
-0.014693693,
0.017220387,
0.0013491894,
-0.019928483,
0.015043543,
0.0031000583,
-0.0025769032,
-0.0056818207,
-0.023297407,
0.052425645,
0.010009592,
-0.0091284895,
0.032497164,
-0.008616672,
-0.02328445,
-0.13703747,
-0.0077679623,
-0.008791597,
0.017466577,
-0.00249268,
0.015769158,
-0.021755477,
0.026316483,
0.006822072,
0.014201311,
-0.023569513,
-0.0037122956,
0.01206334,
-0.006177441,
0.017920086,
-0.0038580662,
-0.00249268,
-0.008947086,
-0.03840574,
0.032730397,
-0.008143727,
0.021457456,
-0.011583917,
0.0013548583,
-0.0106380265,
0.012497414,
-0.034829494,
0.0010293035,
0.002199519,
0.00867498,
0.013695973,
-0.012808391,
0.032315757,
-0.021509286,
-0.018814147,
-0.027832499,
0.013618229,
-0.030527638,
0.02183322,
-0.015173117,
-0.004492979,
-0.0020197348,
0.019397229,
-0.021185352,
-0.030527638,
-0.00047537466,
-0.032471247,
-0.0037284922,
0.014304971,
-0.020615226,
-0.030838614,
-0.028039817,
-0.007009954,
-0.029957512,
0.020187631,
0.0026335919,
-0.014615948,
0.000045528057,
-0.014136525,
0.022869814,
-0.013670058,
0.020083971,
-0.0066147535,
-0.013119369,
-0.0013459501,
-0.02128901,
-0.015263819,
-0.05032655,
0.013786675,
-0.02697731,
-0.0005923962,
0.0150565,
-0.010190996,
-0.013190635,
-0.009102575,
0.004726212,
0.0012552482,
0.011894895,
0.005908575,
-0.013721888,
-0.014032866,
-0.022144198,
0.02104282,
-0.010152124,
0.036669444,
0.021794349,
0.00048630746,
-0.0011483497,
0.0236343,
-0.033352353,
-0.011201673,
0.02128901,
0.0038839811,
-0.019811867,
-0.012413191,
0.0013694353,
0.007009954,
-0.009309893,
0.012387276,
0.021522244,
-0.016766878,
-0.009005394,
-0.04602469,
0.008020631,
0.003116255,
0.005464784,
-0.016533645,
-0.009782838,
0.0178553,
-0.023945278,
-0.0059766015,
0.011363641,
-0.013041625,
-0.0021104368,
0.013119369,
0.017958958,
-0.025811143,
-0.014577077,
0.0437701,
-0.0035762428,
0.011396035,
0.027728839,
-0.008500055,
-0.001964666,
0.019073294,
0.019980313,
-0.007942887,
0.00568506,
-0.003430472,
-0.008435268,
-0.018943721,
-0.0077744406,
0.0051732427,
-0.05289211,
-0.0025250735,
-0.014045823,
-0.006038149,
0.0013378516,
-0.008985958,
0.024048937,
0.020317206,
0.032497164,
0.0012900713,
-0.01605422,
0.04332955,
-0.022468135,
0.0096986145,
-0.0033689244,
-0.0315124,
-0.009640306,
-0.007664303,
-0.018606829,
0.016572516,
0.00012420883,
-0.00045148446,
-0.018503169,
0.0045156544,
-0.021366755,
0.0039520073,
0.010877739,
-0.009329329,
-0.014473417,
0.030553553,
-0.0008811033,
0.009964242,
-0.01027522,
0.0076448666,
-0.00091349677,
-0.011506173,
0.004891419,
0.034026135,
-0.024968913,
-0.046257924,
-0.0010479299,
0.0048493072,
0.009653264,
-0.00031502682,
0.014019908,
0.003929332,
0.004846068,
-0.016935324,
0.019876653,
0.03625481,
0.021366755,
-0.00045836807,
0.020226503,
0.038561225,
0.008260343,
-0.016417028,
0.03674719,
0.015885774,
0.006692498,
-0.02228673,
0.0108712595,
-0.00021642909,
0.011998554,
0.020213546,
0.019915527,
-0.007988238,
0.00932285,
0.006796157,
0.037317317,
-0.025370592,
0.027003225,
0.013592314,
-0.0043148147,
-0.021250138,
0.025603825,
-0.017712768,
-0.029361472,
-0.029361472,
-0.006951646,
0.010825909,
0.018943721,
0.026005505,
-0.005260705,
-0.011771799,
0.016196752,
-0.000031786127,
-0.016041262,
-0.0024910604,
0.03620298,
-0.0044832607,
0.01694828,
-0.01780347,
-0.017881215,
0.0061061755,
0.009880018,
0.043381378,
0.0009774739,
0.011590395,
-0.027884327,
0.010799994,
-0.024878211,
-0.013566399,
-0.009530169,
0.0120179895,
-0.013618229,
-0.0057822405,
0.025215102,
-0.021768434,
0.073805355,
-0.00006898804,
-0.018723445,
-0.010139166,
-0.011648703,
0.026899565,
0.004049188,
0.03107185,
-0.034622177,
-0.030035255,
0.028065732,
-0.015393393,
0.012737125,
-0.014421588,
-0.0108453445,
0.011959681,
-0.014214269,
0.00917384,
0.0056526666,
0.010884217,
0.0039649648,
-0.032315757,
0.00613209,
0.029154154,
-0.024800466,
-0.0035535672,
0.04861617,
0.0033527275,
-0.0056008366,
-0.020615226,
-0.010858302,
0.012141085,
-0.0465689,
0.008331609,
0.00053611246,
-0.011532087,
-0.010288177,
-0.02417851,
-0.0022205748,
0.041593257,
-0.0012317629,
-0.0068933377,
-0.024891168,
-0.027132798,
-0.015600711,
-0.009303414,
-0.03464809,
0.0015969997,
0.0022157156
] |
BACKGROUND Deep vein thrombosis (DVT) and pulmonary embolism are common after stroke. In small trials of patients undergoing surgery, graduated compression stockings (GCS) reduce the risk of DVT. National stroke guidelines extrapolating from these trials recommend their use in patients with stroke despite insufficient evidence. We assessed the effectiveness of thigh-length GCS to reduce DVT after stroke. METHODS In this outcome-blinded, randomised controlled trial, 2518 patients who were admitted to hospital within 1 week of an acute stroke and who were immobile were enrolled from 64 centres in the UK, Italy, and Australia. Patients were | [
-0.027387884,
-0.0035606958,
0.022251807,
-0.039408196,
-0.004682095,
0.021967223,
-0.019378858,
0.009174466,
-0.0051089716,
-0.013653287,
-0.016993769,
0.015259157,
0.014906814,
0.019040067,
-0.016478805,
0.02013775,
0.025124757,
-0.0035268166,
0.014622229,
-0.04347369,
-0.001311969,
0.02104571,
-0.02104571,
-0.006494628,
-0.0077244397,
-0.006569162,
0.036128696,
-0.020205509,
0.0025155249,
-0.020408783,
0.008449453,
-0.0172648,
-0.0057289596,
-0.0410615,
0.005488418,
0.0036894365,
0.006254086,
0.016966665,
0.005844149,
-0.0061626122,
0.007568596,
0.016140014,
0.0059932168,
0.009879152,
-0.026019165,
-0.007412752,
0.01595029,
-0.018945206,
-0.025002792,
0.036697865,
0.037158623,
0.015557293,
-0.010827768,
-0.0056408737,
-0.012664016,
-0.0018362484,
-0.0015271015,
0.030220177,
0.016831148,
-0.016695632,
-0.0021089753,
0.0079006115,
-0.0038757715,
0.00825973,
-0.013497442,
-0.03255106,
-0.018525105,
-0.007148495,
0.025057,
0.025653271,
0.047918633,
0.031602446,
0.0013670226,
0.006535283,
0.021872362,
-0.0033760546,
0.00003255572,
0.00355392,
0.0065014036,
0.0019971742,
-0.006050811,
-0.041332528,
-0.002822131,
0.008944089,
0.012596258,
0.0072298045,
0.0051089716,
0.019785408,
-0.015326915,
0.008571418,
0.0030592848,
0.002659511,
-0.00866628,
0.016004497,
-0.0048006717,
-0.007473734,
-0.013836234,
0.007067185,
0.014771298,
-0.03320154,
-0.0026137743,
-0.014486712,
-0.02531448,
-0.015259157,
-0.035803456,
-0.0086324,
0.0021902854,
0.0114443675,
0.0060135443,
0.0017041198,
-0.01512364,
0.042443763,
-0.004783732,
-0.019744752,
0.029190252,
-0.0007262837,
-0.005573116,
0.008408798,
-0.0048853694,
-0.0059661134,
0.029434182,
-0.0002754796,
0.04537092,
-0.0101434095,
-0.0020361352,
0.010095978,
-0.020395232,
0.008815347,
0.008083559,
0.00084824854,
0.024501381,
-0.005525685,
0.019704098,
-0.024840172,
-0.017603593,
0.013395805,
-0.03246975,
-0.012941825,
-0.027631812,
-0.015814774,
-0.026385061,
0.0017498566,
-0.0039164266,
-0.024108384,
-0.0066199806,
0.008381695,
0.042931624,
0.02719816,
-0.007378873,
-0.021181228,
0.0061558364,
-0.043609206,
0.0049260245,
-0.0037707463,
-0.009296431,
-0.0217775,
0.024582691,
0.020151302,
-0.012894394,
-0.022306014,
-0.029325768,
-0.018321829,
0.011999985,
-0.0070468574,
0.0075076134,
0.012074519,
-0.0048379386,
0.0052343244,
0.000637351,
0.009852049,
-0.005064929,
0.027238814,
-0.024514932,
0.0069452203,
0.0146086775,
0.013280616,
0.0003002537,
0.012582706,
-0.010509304,
-0.00793449,
-0.03705021,
-0.0022885348,
0.022468634,
0.015597948,
-0.03219872,
-0.006823255,
0.032008994,
-0.0045669056,
0.0023715387,
-0.020110646,
0.017535834,
0.00780575,
-0.036020283,
-0.0072298045,
-0.625761,
-0.018430242,
0.025287377,
-0.013660062,
0.029108942,
0.02153357,
0.034746427,
0.008144541,
-0.026032718,
0.037836205,
0.023078458,
0.016966665,
-0.011823813,
-0.0065386705,
0.003977409,
-0.015503086,
-0.0030796123,
-0.003008466,
0.029163148,
0.004712586,
-0.013619407,
0.008645952,
0.008070007,
0.017142836,
0.018457346,
0.02727947,
0.019527927,
-0.0087408135,
-0.006796152,
0.02341725,
-0.01627553,
0.02349856,
0.0044144494,
0.036968898,
0.05111682,
-0.0074669584,
-0.028241636,
0.0051868935,
-0.005867864,
0.026493473,
-0.024840172,
0.01421568,
0.0279435,
0.015909636,
0.016397495,
0.023810247,
0.020598507,
-0.015082985,
-0.013063789,
0.012162605,
0.0006750415,
0.021587776,
0.009309983,
0.0036013508,
0.010726131,
-0.008130989,
0.020652713,
-0.005342738,
0.0039164266,
-0.0017066608,
0.0102247195,
-0.012508172,
0.007067185,
-0.02309201,
0.00080547616,
0.03607449,
-0.010685476,
-0.0092625525,
0.018348932,
-0.0063591115,
0.017305456,
0.020015785,
0.0155301895,
-0.013416133,
0.028810807,
0.022631254,
0.0060779145,
0.017861074,
-0.014500264,
0.011681521,
-0.019040067,
0.011884796,
0.00022296698,
0.0138091305,
0.027225263,
0.017291903,
-0.01734611,
-0.0028865011,
0.010719354,
-0.0094455,
0.0005399485,
0.029352872,
-0.025328033,
-0.010028221,
0.0024409909,
0.031331412,
0.014513816,
-0.0044618803,
0.016668528,
-0.003398076,
-0.01718349,
0.0143783,
-0.011783158,
-0.0037944617,
0.00632862,
0.0052648154,
-0.04978876,
0.014527367,
0.014839056,
-0.01866062,
0.0061829397,
0.0018802913,
0.01595029,
-0.014879711,
0.012230364,
-0.02349856,
-0.016451702,
-0.008991519,
-0.017522283,
-0.031033276,
-0.007250132,
0.00408921,
-0.0009367577,
0.021872362,
0.00702653,
0.01750873,
-0.009391293,
-0.012332001,
-0.02053075,
-0.011688298,
-0.0017117427,
-0.012345552,
0.052146744,
0.003057591,
0.020151302,
-0.02021906,
0.0048819818,
-0.017684901,
0.0025036673,
-0.026290199,
-0.009181242,
-0.0053833923,
0.0000034540824,
-0.011220765,
0.012535275,
0.0017820419,
-0.023525663,
-0.00301016,
-0.018498002,
-0.008944089,
0.010624493,
-0.034773532,
-0.007826078,
0.0016456784,
-0.013693942,
-0.0048853694,
0.0038859353,
-0.017115733,
0.0047905077,
-0.03377071,
-0.00624731,
-0.0018650457,
-0.00070045085,
0.011898348,
-0.013165427,
-0.045181196,
-0.013578752,
0.004367019,
-0.026574783,
-0.023268182,
0.031277206,
-0.0155301895,
0.03303892,
0.028865013,
-0.011363057,
0.020408783,
0.007697337,
-0.023268182,
-0.015841877,
0.011925451,
-0.013849786,
-0.023945764,
-0.029705215,
-0.0033404815,
0.031466927,
-0.0036149023,
-0.0010172207,
-0.0097639635,
-0.018538656,
0.001005363,
0.016153565,
-0.008313937,
-0.013477115,
-0.010976836,
0.006186328,
0.014012405,
0.0017498566,
-0.0057391236,
0.0034048518,
0.001814227,
0.051089715,
-0.030843552,
0.024216797,
0.0068097035,
0.030111764,
-0.014012405,
0.020354576,
0.004556742,
0.03032859,
0.003990961,
-0.00874759,
0.0049328003,
-0.00006071774,
-0.019731201,
-0.022224704,
0.021980776,
0.0006403154,
-0.003057591,
0.0004023146,
0.0072162533,
0.0029407078,
-0.026507026,
0.0238238,
0.014771298,
-0.025680374,
0.013714269,
0.0096826535,
-0.0041061495,
-0.011512126,
-0.031060379,
-0.009384517,
0.020097096,
0.024636898,
0.0073585454,
-0.0020903419,
0.016939562,
-0.0060880785,
-0.017468076,
0.04173908,
0.028566876,
0.016370391,
0.013361926,
0.011850917,
-0.02211629,
0.009032174,
0.00086815254,
0.040085778,
0.009675877,
-0.003984185,
0.028485566,
-0.0077379914,
0.025531307,
-0.0055392366,
0.0010553347,
-0.0065318947,
-0.003628454,
0.026886472,
0.015597948,
0.02292939,
0.028566876,
0.018796137,
0.037673585,
-0.019988682,
-0.008530763,
0.018796137,
-0.021262538,
0.0073924246,
-0.0017066608,
-0.018416692,
-0.030680934,
-0.016546564,
0.0011629008,
0.0142292315,
-0.017034423,
0.01578767,
0.010055323,
0.024054177,
0.016912458,
0.008679831,
0.012582706,
0.010685476,
-0.04295873,
-0.0013306026,
0.0127859805,
-0.010326357,
0.016668528,
0.0014229232,
-0.009987566,
-0.00640993,
0.024352314,
-0.0024020297,
0.0018853731,
0.0037639705,
0.00718915,
0.006907953,
-0.018267622,
0.0059728893,
-0.007907387,
0.013212858,
-0.020232612,
0.0009909644,
-0.0033032144,
-0.009194794,
-0.01882324,
0.021709742,
0.016343288,
-0.015679257,
-0.012765653,
0.008130989,
-0.0063557234,
0.02078823,
-0.031927686,
0.007182374,
0.0036894365,
0.013395805,
0.018538656,
0.0028678677,
0.0046414398,
0.016790492,
-0.009391293,
-0.008252954,
-0.017549386,
-0.0065386705,
-0.034583807,
0.041522253,
-0.0012789369,
-0.0022089188,
0.0038452805,
0.0072027016,
-0.011762831,
-0.02227891,
0.0030762244,
0.04160356,
0.033499677,
0.014988123,
-0.008435901,
-0.0028204368,
0.012210036,
0.027157504,
0.04404286,
0.006406542,
-0.008449453,
0.0055019697,
-0.031223,
0.012372656,
0.03276789,
0.014947468,
0.03832406,
-0.0034963253,
0.00024414144,
0.025029896,
0.013063789,
0.004553354,
0.004546578,
-0.043826032,
0.02538224,
-0.0050717047,
0.029732319,
-0.0028865011,
-0.0092015695,
-0.016451702,
-0.012338776,
0.011139455,
0.017847521,
0.030437004,
0.019880269,
-0.00663692,
0.0064200936,
0.024758862,
-0.03141272,
0.00408921,
0.025978511,
-0.00092490006,
-0.030301487,
0.03499036,
-0.0016414435,
-0.017034423,
-0.008103886,
0.018891,
-0.009174466,
-0.009953686,
0.0096826535,
0.00064285635,
-0.003736867,
-0.010793888,
-0.020097096,
0.00071230857,
0.0055527883,
-0.027862191,
-0.005054765,
-0.021641983,
0.0021005056,
-0.0016863333,
-0.019514374,
-0.0066979025,
-0.0033015206,
-0.029976247,
0.01578767,
0.00809711,
-0.0012298122,
0.042389557,
-0.019812511,
-0.021601329,
-0.0062744133,
-0.017725557,
-0.022170497,
-0.01725125,
-0.0087814685,
-0.00017617144,
0.002781476,
-0.015394674,
0.0062744133,
-0.032171614,
0.006965548,
0.040654946,
0.0010206086,
-0.010848095,
-0.0012645383,
0.0037571946,
0.010102754,
0.021980776,
-0.0007262837,
-0.01676339,
-0.008659503,
0.01734611,
-0.031629547,
-0.0007720205,
-0.03363519,
-0.01113268,
-0.0022309402,
0.018199865,
-0.0058170455,
0.02242798,
0.014107266,
0.044097066,
-0.01273855,
0.013571977,
0.0142292315,
0.012704671,
0.006985875,
0.02736078,
-0.008991519,
0.01031958,
-0.015679257,
-0.005390168,
0.009479378,
0.024298107,
0.012745325,
-0.025449997,
0.014676436,
0.022644805,
-0.026357958,
-0.041711975,
0.015326915,
-0.010861646,
0.026086925,
0.001158666,
0.017603593,
-0.052065436,
-0.00046117956,
-0.013504218,
-0.0028306006,
-0.014025956,
-0.011369834,
0.0026747568,
0.0066199806,
-0.01351777,
-0.017454524,
0.014730643,
-0.025585514,
0.0015364182,
-0.009587792,
-0.023864454,
0.008408798,
-0.004085822,
-0.019351754,
-0.016939562,
-0.013124772,
-0.018511552,
-0.05266171,
-0.009072829,
-0.01939241,
0.0137481475,
0.016939562,
0.046048503,
0.001120552,
-0.00017172481,
0.016207771,
-0.00043407627,
-0.001892149,
0.011322402,
0.0066165924,
-0.004817611,
0.038649302,
-0.005400332,
-0.01643815,
-0.008042904,
0.013754924,
0.015028778,
0.013673614,
-0.011403712,
-0.00034239088,
0.0020378293,
-0.061090834,
-0.011932227,
-0.011593436,
0.01718349,
0.028295843,
-0.040112883,
-0.010705803,
0.034285672,
0.0180779,
-0.009567464,
0.009994341,
0.031006172,
-0.0005615465,
-0.002747597,
0.0061490606,
0.012250691,
-0.016858252,
-0.0069926507,
-0.025544858,
-0.010651596,
0.01569281,
-0.0013382253,
-0.010102754,
-0.0059220707,
0.013585528,
-0.046807397,
-0.007927715,
-0.043012936,
0.005786554,
-0.0049328003,
-0.03303892,
-0.0041840714,
0.0005492653,
-0.0066436958,
0.0012543745,
-0.010665148,
0.0063591115,
0.0062337588,
0.025978511,
-0.03190058,
-0.009791066,
-0.011315627,
-0.017319007,
0.002894971,
-0.01593674,
0.03417726,
0.013504218,
-0.008219075,
0.014486712,
-0.0039638574,
-0.00018400598,
-0.00640993,
0.0019107825,
0.032090306,
-0.034123052,
-0.02292939,
0.0043704067,
0.022387324,
-0.026832266,
-0.02169619,
0.02390511,
0.005254652,
-0.014730643,
0.0017159776,
-0.032605268,
-0.030951966,
0.030138867,
-0.004597397,
-0.024799518,
0.011491799,
-0.0022207764,
0.0083410395,
0.0029068287,
-0.020910194,
0.013477115,
-0.01692601,
0.0143783,
-0.01939241,
0.0071755983,
-0.0029424017,
0.0016431374,
-0.0075550443,
0.0209644,
-0.007920939,
-0.023891557,
0.012779205,
0.009919807,
-0.014175025,
-0.006599653,
-0.027753778,
0.033174437,
-0.00425183,
-0.0074398555,
0.03330995,
-0.024514932,
0.0054985816,
-0.02530093,
-0.011546005,
-0.016993769,
-0.013632959,
-0.0094455,
0.016140014,
0.01864707,
-0.029163148,
0.009099932,
-0.028322946,
-0.012914722,
-0.0062032673,
-0.033066023,
-0.00084613106,
-0.04144094,
-0.010671924,
-0.020774677,
-0.008103886,
0.018362485,
0.010976836,
0.00077710237,
0.007927715,
0.015421776,
-0.0048040594,
0.020503646,
0.005471478,
0.010841319,
-0.030464107,
0.013856561,
-0.00842235,
-0.0443952,
0.009858824,
0.0015482759,
-0.012372656,
-0.03772779,
-0.020029338,
-0.013192531,
-0.036941797,
-0.016411047,
0.029379975,
0.010367012,
-0.0041129254,
0.014798401,
-0.014595126,
0.01866062,
-0.029434182,
-0.0031761678,
0.013510994,
-0.0083207125,
0.000503105,
-0.0123252245,
0.020097096,
-0.002349517,
-0.023403699,
0.0029966084,
-0.014852608,
0.025368687,
-0.024514932,
-0.010861646,
-0.027997706,
-0.016383944,
-0.021791052,
-0.00040633773,
-0.00033942645,
-0.013239961,
0.00973686,
-0.017901728,
-0.004902309,
0.007961594,
-0.0254771,
0.010610941,
-0.011681521,
-0.014080163,
-0.014974572,
0.02244153,
-0.015272709,
0.028295843,
0.0036318419,
-0.022007879,
-0.019338204,
0.0025765072,
-0.044639133,
-0.0044178376,
-0.0051089716,
0.019297548,
0.004556742,
0.02440652,
-0.0016050234,
0.030843552,
0.0067792125,
-0.0071349433,
0.0155708445,
0.008388471,
0.014500264,
-0.0046312762,
-0.018254071,
-0.010062099,
-0.039245576,
-0.0008342734,
0.007832853,
-0.0059220707,
0.0073178904,
-0.0025290765,
0.0048921453,
0.0014949163,
-0.009818169,
0.012603033,
0.011417264,
-0.016573668,
-0.030464107,
-0.02646637,
0.013212858,
0.0044483286,
-0.0001286348,
-0.0138091305,
-0.0051259114,
-0.0064336453,
0.0032151288,
0.003980797,
-0.0123658795,
0.010089203,
0.005644262,
0.0032523957,
0.014269887,
-0.00239356,
-0.030193074,
0.015503086,
0.028566876,
0.023444353,
-0.020977953,
0.0088221235,
0.008381695,
-0.0038046255,
0.0172648,
-0.01577412,
-0.023715386,
-0.011728953,
0.0033879122,
0.004936188,
-0.0015923188,
-0.011315627,
0.0010934487,
-0.009350638,
0.039625023,
-0.0023850903,
-0.028892115,
0.019866718,
-0.010075651,
-0.014025956,
-0.02497569,
-0.020517197,
-0.006338784,
-0.02736078,
-0.016411047,
0.026534129,
-0.00014673895,
0.0020666264,
-0.004360243,
-0.0037233157,
0.00086180016,
0.016573668,
0.20208219,
-0.009052501,
-0.00013022288,
0.0124065345,
0.014825504,
-0.008300385,
0.022739667,
-0.0074059763,
-0.024474278,
0.012230364,
0.02030037,
-0.0039401418,
-0.025748134,
-0.010197616,
-0.011546005,
-0.010963284,
0.0011324097,
-0.023539213,
0.01397175,
-0.0029644233,
-0.01741387,
0.022373773,
0.0007834547,
-0.0077447672,
0.030193074,
0.009709757,
0.02072047,
0.014717091,
0.031331412,
0.017359663,
-0.00083257945,
0.009113484,
0.00067631196,
0.010211168,
0.014080163,
-0.020991504,
0.013693942,
-0.00041967764,
-0.015191399,
-0.011600211,
-0.0014551083,
-0.01734611,
-0.043175552,
0.00046880235,
-0.023078458,
0.019731201,
-0.0053461255,
-0.010719354,
-0.009113484,
0.0067385575,
-0.022617701,
0.0017888177,
0.018105002,
0.029515492,
-0.006840195,
-0.004942964,
0.02523317,
0.002700166,
-0.009852049,
0.018782586,
-0.010360235,
0.014974572,
-0.013802354,
0.014120818,
-0.00034175566,
0.020408783,
-0.009337086,
-0.013931096,
-0.024758862,
-0.0029440958,
0.0021140573,
0.0056916927,
-0.004553354,
0.01898586,
-0.032740783,
-0.032008994,
0.016871803,
0.016804045,
0.010820991,
0.0069045653,
0.0014661191,
-0.022468634,
-0.008076782,
-0.0017210594,
-0.0075821476,
-0.031466927,
0.02284808,
0.03081645,
-0.024867276,
0.014513816,
0.006050811,
0.00027886752,
-0.018403139,
-0.0026476535,
0.020476542,
0.0076363543,
-0.015313364,
0.018958757,
0.0074398555,
0.006592877,
-0.038974542,
0.056266446,
0.010577062,
-0.010495752,
0.011972882,
0.023606973,
-0.028322946,
0.003513265,
-0.020097096,
-0.004756629,
-0.01335515,
-0.03870351,
0.024067728,
-0.008686607,
-0.0008952558,
0.01750873,
0.036101595,
0.0033337057,
0.017847521,
-0.009093156,
0.0036182902,
-0.017481627,
-0.015475983,
0.024935035,
0.0063116807,
-0.011037818,
-0.01195933,
-0.004143417,
-0.037782,
-0.03396043,
0.010739682,
-0.024948586,
-0.0017871237,
-0.03810724,
-0.02685937,
0.02851267,
-0.0017193655,
-0.0050683166,
-0.005224161,
0.018050797,
0.004902309,
-0.014025956,
0.004929412,
-0.0041400287,
0.042769004,
-0.008435901,
0.010089203,
0.01019084,
-0.014093715,
-0.015150744,
-0.01593674,
-0.009113484,
-0.0019887045,
-0.018321829,
0.00010105507,
-0.0267103,
-0.017630694,
-0.04176618,
0.0072162533,
0.020422336,
-0.024474278,
0.018443795,
0.0304099,
-0.027835088,
0.015719913,
0.0055697276,
-0.17150967,
0.013117996,
0.015597948,
-0.0020700144,
0.037104417,
0.012101622,
0.024718208,
0.010651596,
-0.02549065,
-0.010387339,
0.01290117,
0.0180779,
-0.030708037,
-0.005407108,
-0.0053156344,
0.004858266,
-0.020056441,
0.009188018,
0.031521134,
0.030708037,
0.036210004,
0.0032862748,
-0.002584977,
-0.003509877,
-0.0036962123,
-0.029542595,
-0.008964416,
0.031195896,
-0.010414442,
-0.008510436,
-0.0024951973,
-0.0012204954,
0.03246975,
-0.011532453,
-0.01955503,
0.008612073,
-0.0060846903,
-0.00013276382,
0.00022254349,
0.01872838,
0.016885355,
0.035776354,
-0.007195926,
-0.010034996,
0.010875198,
0.017224146,
0.0128876185,
-0.016966665,
0.022495737,
0.0009951992,
0.009608119,
0.0054206597,
0.007751543,
0.006250698,
-0.002009032,
0.021872362,
0.0030609786,
-0.007290787,
0.0005556176,
-0.029163148,
0.011498574,
-0.02357987,
-0.009072829,
0.0070739607,
-0.007981922,
-0.029407078,
-0.0063929902,
-0.034312773,
0.00036928244,
0.022224704,
-0.023986418,
-0.024840172,
0.003054203,
-0.021154124,
0.03385202,
0.031927686,
-0.020828884,
0.00032799225,
-0.008537539,
-0.004746465,
-0.002349517,
0.025937855,
-0.009635222,
-0.01343646,
0.018294726,
0.024203245,
0.014405403,
-0.014080163,
0.0029525654,
-0.016397495,
0.029136045,
-0.03761938,
-0.00078091375,
0.010820991,
0.0077312156,
0.027428538,
-0.002591753,
-0.01080744,
-0.00040633773,
-0.009309983,
0.01799659,
0.005288531,
-0.029542595,
-0.017319007,
0.033011816,
0.026371509,
0.0009579322,
-0.0035268166,
0.030111764,
0.010624493,
0.014947468,
0.005088644,
0.0061592245,
0.012155829,
0.012799532,
0.02685937,
0.0011002246,
-0.015557293,
-0.0016863333,
-0.04279611,
0.040898878,
-0.0058814157,
-0.022075636,
0.004983619,
0.01359908,
0.0068639102,
-0.11936293,
-0.012535275,
0.015421776,
0.027238814,
0.01010953,
0.00034662578,
-0.023878006,
0.001856576,
0.014798401,
0.02736078,
-0.021913016,
-0.011430816,
-0.0045669056,
0.0021021995,
0.0443952,
-0.021750396,
-0.0097233085,
-0.041197013,
0.011335954,
0.04558775,
0.002161488,
-0.00478712,
0.00044296953,
-0.038080133,
0.016045153,
-0.0037775221,
-0.02309201,
-0.0097639635,
0.026845817,
0.008700158,
0.0051123598,
0.0007499991,
-0.0060474235,
0.0020141138,
-0.037538067,
-0.017888177,
-0.016343288,
-0.031981893,
0.046238225,
-0.005715408,
0.016993769,
-0.0010587226,
0.0041468046,
-0.0037334792,
0.004763405,
-0.009174466,
-0.044612028,
0.00949293,
0.0014601902,
0.001856576,
-0.010333132,
-0.03309313,
-0.016397495,
0.014486712,
0.008042904,
0.00470581,
0.025856547,
0.013917544,
0.008984744,
0.011695073,
0.0028255188,
-0.0036386177,
-0.027862191,
0.039326884,
0.020110646,
-0.023945764,
-0.018999413,
-0.016478805,
0.010488977,
-0.005559564,
-0.000558582,
0.010529631,
-0.024311658,
0.01121399,
-0.03626421,
0.0011933921,
0.002735739,
-0.0073043387,
0.0021055874,
-0.0064200936,
-0.005251264,
-0.008998295,
0.023308836,
-0.033987537,
0.01359908,
0.027021987,
-0.003050815,
0.015326915,
-0.005515521,
-0.010007893,
-0.0043873466,
0.025206067,
-0.003594575,
-0.036318418,
0.014012405,
-0.0014771298,
-0.021641983,
-0.015679257,
0.0068808496,
0.01609936,
-0.010028221,
-0.017156387,
-0.057621613,
0.015232054,
0.010963284,
-0.0022038368,
-0.0017363051,
-0.010150185,
0.029271562,
0.0238238,
0.0041501927,
-0.028485566,
-0.021127021,
-0.008042904,
-0.01166797,
0.028485566,
-0.010292477,
-0.0065318947,
0.018714827,
0.020937297,
0.031358514,
0.010820991,
-0.011803486,
-0.020354576,
0.003858832,
0.0336894,
0.003913039,
0.0094455,
0.010963284,
0.028892115,
-0.028919218,
0.0087814685,
-0.017820418,
-0.02333594,
0.006321844,
-0.015082985,
0.02218405,
-0.0022800649,
-0.019866718,
0.022048533,
0.034773532,
0.0064336453,
-0.009743636,
-0.0016194221,
0.022509288,
-0.023850903,
-0.01660077,
0.024962137,
-0.01413437,
0.019880269,
-0.018714827,
-0.019866718,
0.015421776,
0.0051259114,
0.01413437,
-0.038676407,
-0.026005615,
0.021208331,
-0.007812526,
0.0024189693,
-0.008042904,
-0.017115733,
0.016871803,
0.003208353,
0.019338204,
0.0003205812,
0.028566876,
-0.022780322,
-0.010421218,
-0.020069992,
0.0019175584,
-0.028241636,
-0.008327488,
-0.030762244,
0.007182374,
-0.014175025,
-0.0040688827,
-0.0010460179,
0.008706935,
-0.006074527,
-0.000052274427,
0.024094831,
0.009960462,
0.011247869,
-0.046211123,
0.016451702,
0.03705021,
0.0036182902,
-0.018254071,
0.025680374,
-0.022089187,
0.00486843,
-0.0073246663,
0.008930537,
-0.0031033277,
-0.015421776,
0.021736845,
0.029488388,
-0.012514948,
0.019365307,
0.0059999926,
0.015841877,
0.0037775221,
0.013178979,
-0.009472603,
-0.02843136,
-0.011274972,
-0.0033929942,
-0.007487286,
-0.024067728,
-0.01577412,
0.00013255207,
0.03756517,
-0.0003362503,
-0.01097006,
0.00825973,
-0.008693383,
0.0014212292,
-0.009465827,
-0.025124757,
-0.018796137,
0.009391293,
-0.011119128,
0.023606973,
-0.014947468,
0.009919807,
0.019134928,
-0.0033913,
0.029813629,
-0.008578193,
0.016153565,
0.02367473,
-0.0038147892,
-0.011640866,
-0.021885913,
-0.007616027,
0.00085121294,
-0.02549065,
0.0006127886,
0.031683754,
0.0023783145,
0.073937796,
0.0051462385,
-0.027252367,
-0.007521165,
-0.018010141,
-0.013998853,
0.012332001,
0.014717091,
-0.0047600167,
-0.022617701,
-0.01742742,
-0.006223595,
-0.014920366,
-0.045560643,
-0.023810247,
0.013863337,
-0.004712586,
0.02367473,
-0.007988697,
0.027455641,
0.013741372,
-0.008124214,
0.020042889,
0.0014618841,
-0.0066098166,
-0.012603033,
0.01413437,
0.013043462,
-0.026507026,
-0.0111055765,
-0.008266506,
0.013253513,
-0.01635684,
-0.017319007,
0.003438731,
0.0092015695,
0.02399997,
-0.046861604,
0.009350638,
0.011573108,
-0.014798401,
0.029705215,
-0.019948028,
-0.019582132,
-0.032686576,
-0.037836205,
-0.00702653,
-0.01577412,
-0.0024308271
] |
BACKGROUND Streptococcus pneumoniae infection starts from colonization of the host respiratory tract where interaction with host respiratory tract epithelial cells occurs. To investigate pneumococcal genes that are involved in the early stage of interaction with host epithelial cells, transcriptional responses of an encapsulated pathogenic pneumococcal strain TIGR4 upon exposure to human lung epithelial cells A549 for 0.5 h and 1 h time periods were investigated by using TIGR (JCVI) microarray technology. Gene expression changes were validated by quantitative real-time PCR (qRT-PCR) analysis. FINDINGS We observed different | [
-0.0105662905,
0.0026332343,
0.0075044674,
-0.032365933,
0.0010856463,
0.009999286,
-0.0068774275,
0.0030985111,
-0.031111855,
0.0038156048,
-0.002296367,
0.014622038,
0.011426803,
0.025228351,
0.0065205484,
-0.002331388,
0.030471474,
-0.01642311,
-0.02582871,
-0.0010106016,
-0.013294581,
0.0063737943,
-0.0053731985,
-0.0077446103,
-0.00962573,
0.014982252,
0.012734247,
-0.03231257,
-0.018024063,
-0.008771889,
-0.0033069686,
0.010713045,
-0.0089519955,
0.0026815964,
-0.011186659,
-0.02959095,
0.00470947,
-0.0072443127,
0.031538777,
0.020959144,
0.025762003,
0.018851222,
-0.010626326,
0.018597739,
-0.0012324003,
0.008591781,
-0.001650149,
-0.010973199,
-0.0058801672,
-0.004542704,
-0.004766171,
0.0011290055,
-0.03084503,
0.009905897,
-0.023293868,
-0.010472901,
0.0058935084,
-0.0018727815,
-0.013394641,
-0.025495177,
0.00930554,
-0.0037922575,
-0.028150091,
-0.0017793926,
-0.010739727,
0.01726361,
-0.0013191187,
0.0137948785,
0.0036788567,
0.0039256704,
0.040317334,
0.027483027,
0.008018106,
0.010759739,
0.019184755,
-0.022773558,
-0.009145444,
0.0038356166,
-0.011967124,
0.022013105,
0.0038222754,
-0.026322337,
-0.01757046,
0.021893034,
-0.0027082788,
-0.007511138,
-0.0036988687,
0.027029425,
-0.004015724,
-0.005930197,
0.010799763,
0.025548542,
0.011626922,
0.021399407,
0.0014567005,
0.011006553,
-0.0041324603,
0.008525075,
0.02406766,
-0.03660846,
-0.0023397263,
-0.010893151,
-0.010993211,
-0.014915546,
-0.038102683,
0.0039256704,
0.008938654,
-0.0046494347,
0.021959739,
-0.019118048,
-0.01067302,
0.013754855,
-0.026855988,
-0.031191902,
0.04255867,
0.013067779,
0.027149497,
0.0020111974,
-0.026802622,
-0.02718952,
0.025988804,
0.002296367,
0.011733652,
-0.0137281725,
0.04090435,
0.00324193,
-0.019518286,
-0.0045226924,
-0.0062203696,
-0.018050745,
-0.007311019,
0.007677904,
0.027269566,
0.0071575944,
-0.017343659,
-0.021639548,
-0.02394759,
-0.018250866,
-0.04183824,
-0.015529245,
-0.003060155,
0.014141752,
-0.0011056582,
-0.009172127,
0.0062170345,
0.013994998,
0.029777726,
0.017944016,
0.01891793,
0.016489817,
0.028416917,
-0.017970698,
-0.0062370463,
-0.01107993,
-0.012514116,
0.012921025,
0.0039890413,
0.038636334,
-0.02384086,
-0.008004765,
-0.007851341,
-0.0051730797,
0.0017343658,
0.028603695,
0.017090173,
0.03674187,
0.017610483,
0.024334487,
0.0071375826,
-0.020465517,
-0.018464325,
-0.0046694465,
-0.017236928,
0.01694342,
0.036528412,
0.008438357,
-0.01516903,
-0.00013080704,
-0.013741514,
-0.027456345,
0.0034820728,
0.03273949,
0.021706255,
0.0042391904,
-0.026068853,
-0.02457463,
0.030898394,
0.008685171,
-0.005796784,
-0.012000477,
-0.023173796,
0.011173318,
0.015635975,
-0.016756643,
-0.64465046,
-0.027616441,
0.0038689699,
0.0112000005,
-0.0025731986,
0.0032836215,
0.009465635,
-0.017450389,
-0.03378011,
0.028203456,
-0.0013816558,
-0.0015000596,
0.016396428,
0.00005393836,
-0.012400716,
-0.03023133,
0.0011865397,
-0.0054632523,
0.03839619,
0.007571174,
-0.012474093,
-0.010719715,
0.021252653,
0.05646028,
0.0033536633,
0.03217916,
0.03220584,
-0.02123931,
0.002017868,
0.030578203,
-0.029617632,
0.012941037,
-0.0018527696,
-0.008898631,
0.051443957,
-0.0036088151,
-0.010699703,
0.027776536,
0.028577013,
0.033513285,
-0.0023814177,
-0.016970102,
-0.002855033,
0.0035187614,
-0.021185946,
0.030071234,
-0.0019111377,
0.025788685,
0.0045360336,
-0.0129543785,
0.008511734,
0.025188329,
-0.010226088,
0.0046394286,
0.026722575,
-0.004832877,
0.024201075,
-0.015769389,
0.011767005,
-0.009699107,
0.013741514,
0.009679096,
-0.010906492,
-0.008725194,
-0.00591352,
0.00068374036,
-0.0059468737,
0.0076712333,
0.004542704,
-0.008711853,
0.02364074,
0.027856583,
0.003962359,
0.013187851,
0.0042625377,
0.055392977,
-0.025815368,
0.0043759383,
-0.0072042886,
0.018064087,
-0.005900179,
0.008891961,
-0.032285888,
0.022293271,
0.0076912455,
-0.0046294224,
-0.037515666,
0.027936632,
-0.0196517,
-0.007677904,
-0.007791305,
0.013768196,
-0.016569864,
-0.049229305,
-0.034367125,
0.0096524125,
-0.005783443,
-0.026108876,
-0.013034427,
-0.0011198333,
-0.0104262065,
-0.01955831,
0.012287315,
-0.0017143539,
0.033913523,
0.0016343063,
-0.026202265,
-0.0074711144,
0.034553904,
-0.031512093,
-0.002619893,
-0.0107797505,
-0.013954974,
-0.027536392,
-0.00920548,
-0.03105849,
0.030898394,
0.019544968,
-0.0049529485,
-0.03663514,
0.012313997,
0.0032185828,
-0.012507446,
-0.008851936,
0.0031702206,
0.016890055,
0.0027299586,
-0.027176179,
0.00007363759,
-0.0034653964,
0.008698512,
-0.02226659,
0.025535202,
-0.005323169,
0.02865706,
0.015756046,
0.03588803,
0.0026065516,
-0.0014125075,
-0.0230137,
-0.018797858,
0.005032996,
0.023814177,
0.013834903,
-0.017437046,
-0.009772484,
-0.015209055,
-0.01495557,
-0.0038956525,
-0.0031985708,
0.017090173,
-0.0037689104,
0.017903991,
0.009072067,
0.017783921,
-0.012280644,
-0.025708638,
-0.026535798,
0.0068907687,
-0.012474093,
0.0011923765,
0.010086005,
-0.0035020849,
0.0034787375,
0.0059368676,
0.00096640864,
-0.015542586,
-0.005603336,
0.031458728,
-0.024774749,
0.01966504,
-0.010693032,
-0.00069958315,
0.014768792,
-0.011673616,
0.008805241,
-0.0159028,
-0.011940442,
-0.0181975,
-0.010626326,
-0.0038689699,
-0.034687318,
0.0025798692,
0.013888268,
0.0069041103,
0.039490175,
0.017383682,
-0.010619655,
0.0076045273,
0.04957618,
-0.011380108,
0.0042191786,
-0.02185301,
0.02017201,
0.0128876725,
-0.020238714,
0.009338893,
0.016249673,
-0.00044568197,
0.006273735,
-0.026402384,
-0.021679573,
-0.005943538,
-0.025601909,
0.022186542,
-0.018037405,
-0.010999882,
-0.025188329,
0.01893127,
-0.0051297206,
0.012387374,
-0.00075878506,
-0.014582015,
0.008224896,
-0.012694224,
0.0057067308,
0.0076178685,
-0.012220608,
-0.007571174,
-0.0027382968,
-0.029964505,
0.016289698,
0.01454199,
0.011460155,
-0.047041338,
0.026068853,
0.005343181,
0.010025969,
-0.006167005,
-0.009719119,
0.0036888628,
0.009085408,
0.029564267,
-0.019104706,
0.0077245985,
0.022520073,
0.0010397857,
0.003682192,
0.01757046,
0.010486242,
-0.017143538,
0.00805146,
-0.0006483026,
-0.02175962,
-0.010646338,
0.0064471713,
0.016276356,
0.000024324376,
-0.009805838,
0.0122539615,
-0.0017377011,
0.013041097,
-0.013067779,
-0.010126028,
-0.006467183,
-0.013968316,
-0.0022830258,
0.025068257,
0.032392617,
0.022400001,
0.0034820728,
-0.012934366,
0.008845266,
-0.013608101,
0.012941037,
0.0050029783,
-0.007731269,
-0.018704468,
-0.02980441,
0.019291485,
-0.0284436,
0.011566886,
0.030391425,
-0.035701253,
-0.016716618,
0.0026665875,
0.013488029,
0.0038356166,
0.0048695654,
0.0037422278,
-0.008518404,
-0.011113282,
0.020692319,
0.028363552,
-0.013848244,
-0.007817987,
-0.021786302,
-0.011466826,
-0.022666827,
0.012367362,
0.0035054202,
0.015475879,
0.0067440146,
0.01568934,
0.015435856,
-0.011386779,
0.0059535443,
-0.0067706974,
0.01893127,
0.012707565,
-0.0027399645,
0.0010347827,
-0.019118048,
-0.01766385,
0.027803218,
0.0021362717,
-0.018531032,
-0.024454558,
-0.019384874,
-0.022146517,
0.0052964864,
0.01777058,
-0.011220013,
-0.013401311,
-0.0058734966,
0.019011317,
-0.016810007,
-0.0012465754,
0.04162478,
-0.0088119125,
-0.010899822,
-0.051230498,
-0.012567482,
-0.014021681,
0.023040382,
0.035274334,
-0.014301848,
0.017610483,
0.00637713,
0.019051341,
0.0053298394,
-0.038049318,
0.011526862,
-0.010392854,
-0.005943538,
0.003672186,
0.039276715,
-0.0005815962,
0.022106493,
0.020545565,
0.01516903,
-0.020438835,
-0.009605719,
0.025375105,
0.0181975,
-0.0038923172,
0.030471474,
0.031352,
0.029270759,
-0.017036809,
0.0011706969,
0.012587493,
0.010886481,
-0.017357,
-0.026949376,
0.02102585,
-0.0065905903,
0.010119357,
-0.00089636695,
-0.0059868973,
0.0014433593,
0.002981775,
-0.00449601,
0.010412865,
0.010059322,
0.018344253,
0.0051730797,
0.005710066,
0.016556524,
-0.00011454736,
0.01997189,
-0.0028083385,
0.0005265635,
-0.039650273,
0.01266087,
-0.019398214,
-0.002883383,
-0.026055511,
0.014928888,
0.0119004175,
-0.0114801675,
-0.011233354,
0.0057434193,
-0.013541395,
-0.020745683,
-0.027963314,
-0.001385825,
-0.008725194,
-0.02509494,
-0.015275761,
0.0072042886,
-0.008485051,
-0.022373319,
-0.004886242,
-0.0020962479,
-0.03265944,
-0.021306017,
0.019638358,
0.022853605,
0.028016679,
0.017703872,
-0.0026399049,
-0.006450507,
0.008451698,
-0.009438952,
-0.02718952,
0.0037722457,
-0.015609292,
0.01925146,
-0.013781537,
-0.001709351,
-0.0007341871,
-0.027669806,
-0.0011940441,
0.003153544,
-0.011186659,
-0.0142885065,
0.0031568792,
-0.001542585,
0.03273949,
0.010406195,
0.028123409,
-0.017423706,
-0.005499941,
-0.005363193,
-0.059662186,
0.010579632,
-0.018677786,
-0.0015050627,
-0.017703872,
0.009012031,
0.008405004,
-0.02448124,
0.012047172,
0.019918524,
-0.022946995,
0.0021562837,
0.02058559,
0.021306017,
0.02897725,
-0.017410364,
0.0056000003,
0.010072663,
-0.0090920795,
-0.014341871,
0.02059893,
0.031085173,
0.0058201314,
-0.030364743,
-0.005853485,
0.0016668256,
-0.017637167,
-0.036368318,
-0.012420728,
-0.009192139,
0.015409173,
0.027803218,
-0.018384278,
-0.022359978,
0.0045660515,
-0.010172723,
0.002860036,
0.0077112573,
-0.029644314,
-0.018357595,
-0.00674735,
0.016609889,
-0.017370341,
0.0034453843,
-0.037702445,
-0.021999763,
0.026695892,
-0.020225374,
-0.0016759977,
0.00015113164,
0.027776536,
-0.015809411,
-0.00045026804,
-0.020025255,
-0.044373084,
-0.017437046,
-0.012200597,
0.034874093,
-0.0016693271,
0.020839073,
0.013194522,
0.025628591,
0.02300036,
-0.0041257893,
0.0073910668,
-0.011173318,
0.015756046,
-0.006303753,
0.011133295,
0.006600596,
-0.0035321028,
-0.0007129244,
0.009672425,
-0.011273378,
0.009612389,
-0.006273735,
-0.006287076,
-0.012907684,
-0.03084503,
-0.037168793,
0.024494583,
-0.0059568794,
0.023707448,
-0.052457895,
0.011240025,
0.011947112,
-0.016876714,
0.0068974392,
-0.0019344849,
0.02959095,
-0.016783325,
0.010939846,
-0.019118048,
0.002898392,
0.006567243,
-0.019905183,
-0.010479572,
-0.02634902,
-0.009565694,
-0.013061109,
0.023067065,
0.0032519358,
-0.00051989284,
-0.01171364,
-0.0029467542,
-0.019371532,
-0.041491367,
-0.017143538,
-0.020252056,
-0.020252056,
-0.006523884,
-0.008318285,
-0.025054915,
-0.016756643,
-0.0024264446,
0.0052531273,
0.021559501,
-0.025695296,
-0.012514116,
0.02342728,
0.0047328174,
0.036661826,
-0.027776536,
0.033726744,
0.0074110785,
-0.015289102,
-0.038556285,
0.015048959,
-0.0030434786,
-0.0033553308,
0.019931866,
0.032472666,
-0.008324956,
-0.008331627,
0.0005649196,
0.000102508944,
0.0012132223,
0.0031502086,
0.035727937,
0.0028133416,
-0.011653604,
-0.024934843,
-0.027856583,
-0.02090578,
0.010799763,
-0.014355212,
0.015862776,
-0.012981061,
-0.006570578,
-0.024534605,
0.013508041,
0.011560216,
0.0017560454,
0.004592734,
0.0061736754,
-0.017623825,
-0.013301251,
-0.0011631924,
0.0033519955,
-0.0055666473,
-0.0047861827,
0.00013674807,
0.023080407,
0.021906374,
0.0000043222344,
0.011253366,
0.010959858,
0.0040857657,
0.04589399,
-0.0043359147,
-0.01883788,
-0.013141156,
0.030791664,
0.0230137,
-0.021572843,
-0.00068040506,
-0.015676,
-0.008911972,
-0.017490413,
0.023387255,
0.01474211,
-0.010479572,
0.0015450865,
-0.010099346,
0.013574748,
0.00311352,
-0.01129339,
-0.0013458012,
-0.04693461,
0.0003030971,
0.0014100061,
0.0084583685,
0.030258013,
0.009245504,
0.010179393,
-0.014088387,
0.019878501,
-0.020025255,
0.011867065,
0.02185301,
0.0018727815,
-0.01799738,
-0.0053398455,
-0.014768792,
-0.026615845,
0.0046260874,
-0.022960335,
0.009325552,
-0.0259221,
-0.01516903,
0.026362361,
-0.005469923,
-0.0261489,
0.007978083,
-0.0041024424,
0.017290292,
-0.00009776653,
0.0042225136,
0.011573557,
0.0068907687,
0.009565694,
0.018877905,
0.0026465754,
0.0006232877,
-0.006480525,
-0.007898035,
0.007371055,
-0.027856583,
-0.003755569,
-0.0072309715,
-0.0042225136,
-0.004736153,
0.0061970223,
0.0046060756,
-0.012367362,
-0.01642311,
0.021145921,
-0.0030368078,
-0.007851341,
-0.01317451,
0.0059568794,
0.006450507,
0.01171364,
-0.009332222,
0.017957358,
0.021772962,
-0.01244741,
-0.018624421,
-0.00013007743,
0.006910781,
0.037328888,
0.021946399,
-0.012020489,
-0.016116261,
-0.006357118,
-0.06542561,
-0.0027633116,
-0.00005477219,
-0.0024114356,
0.012634188,
0.00565003,
-0.015635975,
0.007457773,
-0.0135880895,
0.032579396,
-0.026175583,
-0.0011348423,
0.025241693,
-0.019518286,
-0.0020228708,
0.012494105,
-0.0284436,
-0.00846504,
0.04570721,
0.000092867784,
-0.023400597,
0.019278143,
0.013267899,
0.023467304,
-0.011733652,
-0.00042587853,
0.00034103636,
0.023560693,
0.010572961,
0.001772722,
-0.008118167,
0.020945802,
0.008425016,
-0.010126028,
0.005053008,
0.0114801675,
0.017330317,
0.0019511615,
-0.005019655,
-0.030498156,
0.000057377907,
-0.015515904,
0.018664444,
0.022293271,
-0.0038189401,
0.016569864,
-0.00015165278,
-0.0030935083,
-0.008438357,
0.0020879097,
-0.0047628353,
-0.019438239,
0.0009572365,
-0.024561288,
-0.017196905,
0.0041658133,
-0.008271591,
-0.011940442,
-0.005499941,
0.0030368078,
-0.011280049,
-0.010766409,
0.004049077,
0.011566886,
-0.008071472,
-0.001425015,
-0.03618154,
-0.018344253,
-0.020118644,
-0.0069374633,
0.013608101,
-0.02226659,
0.01766385,
-0.02226659,
0.0024798096,
-0.008538417,
0.0077646226,
0.009945921,
-0.004022395,
-0.0044826684,
0.17354332,
-0.007477785,
0.0012549137,
0.0049629547,
-0.0095857065,
-0.029937822,
-0.0030935083,
0.007297678,
-0.016556524,
0.03033806,
0.015822753,
0.0022296607,
-0.002296367,
0.003060155,
0.015942825,
-0.008538417,
-0.035727937,
-0.00439595,
-0.023974271,
-0.022826923,
0.00050113164,
-0.010746397,
0.014528649,
-0.0038723052,
0.021265993,
-0.0008580108,
-0.034740683,
0.00679738,
0.022826923,
-0.0064271595,
-0.01266087,
0.026175583,
0.00015008936,
-0.0036755214,
0.007384396,
0.0030151282,
0.012213938,
0.015048959,
-0.017170222,
0.015956165,
0.009905897,
0.014662062,
-0.023120431,
-0.015355808,
-0.013481359,
0.019958548,
-0.009639071,
0.003330316,
-0.013061109,
-0.002503157,
-0.025014892,
-0.007918047,
-0.0063371058,
-0.0013266231,
-0.0005882669,
-0.021319358,
0.022306614,
0.02039881,
0.002369744,
0.03986373,
-0.009525671,
0.026469091,
-0.025068257,
0.019625016,
-0.0021512806,
0.024561288,
0.0069908286,
0.026002146,
-0.021879692,
-0.021933056,
0.004392615,
-0.012780942,
-0.011280049,
0.008324956,
-0.029724361,
-0.0073043485,
0.034260396,
0.007597856,
0.022666827,
0.018370936,
0.027563075,
-0.00039877906,
-0.049629547,
0.014488625,
-0.025628591,
-0.026949376,
0.02772317,
0.018771175,
-0.031458728,
0.009218821,
0.016476475,
0.015075642,
0.0020145327,
-0.009465635,
0.014275165,
-0.00825825,
-0.0074511026,
0.017290292,
0.003965694,
-0.00332031,
-0.02750971,
0.053098276,
-0.007978083,
-0.011166648,
-0.010386183,
0.030551521,
0.005886838,
0.0035821325,
0.0058734966,
0.0010939846,
-0.00086468144,
-0.0017393688,
0.013521383,
-0.0072042886,
0.013754855,
0.024467899,
0.021279335,
-0.03911662,
0.032285888,
-0.006033592,
-0.00837165,
-0.010579632,
0.0056933896,
0.026682552,
-0.013474688,
-0.020932462,
-0.021319358,
0.024147708,
-0.0028416917,
-0.04173151,
0.007270995,
-0.023267185,
-0.019785112,
0.028390234,
0.0051163794,
0.013981657,
0.02498821,
0.003315307,
-0.028070044,
0.01705015,
-0.014048363,
-0.016529841,
0.01957165,
0.015862776,
-0.011720311,
-0.013354617,
0.005773437,
-0.016436452,
-0.008238237,
-0.0050363317,
-0.031005124,
-0.026615845,
-0.007898035,
0.0022446697,
0.016756643,
-0.023587376,
-0.009952592,
-0.027229544,
0.0070241815,
0.0013332937,
-0.0078113168,
0.003919,
0.013087791,
-0.013468018,
0.0053598573,
-0.015315784,
-0.1682068,
0.01997189,
0.004259202,
0.014061704,
0.029030615,
0.012013819,
-0.008098154,
0.018744493,
0.0016609888,
0.014795475,
0.040717572,
0.017236928,
-0.009852532,
-0.01632972,
0.007964741,
-0.014662062,
-0.008478381,
0.012794283,
0.031218585,
-0.0013132818,
0.044719957,
-0.017343659,
-0.012881001,
0.020972485,
-0.000114130446,
0.010893151,
0.008198214,
0.0030334725,
-0.032792855,
-0.015048959,
-0.024334487,
0.0142218,
0.031965695,
0.0027316262,
0.014355212,
-0.0159028,
0.0011114951,
-0.020265397,
-0.0012307327,
0.0001865694,
0.04538702,
0.019611675,
0.013347946,
-0.0050263256,
-0.020518882,
0.021092556,
-0.005680048,
0.008585111,
0.031565458,
0.002546516,
0.005509947,
-0.018544372,
0.0062804054,
0.034687318,
0.015529245,
0.0040757596,
0.015102324,
-0.00617034,
-0.0041057775,
-0.015769389,
0.01266087,
-0.019785112,
0.035381064,
-0.01600953,
0.00055074453,
-0.048935797,
-0.0041958313,
0.011533532,
-0.009492317,
0.02007862,
-0.027456345,
-0.023694105,
0.001757713,
-0.026028829,
0.022826923,
0.01693008,
-0.010019298,
0.001150685,
0.0013307922,
-0.001650149,
-0.0031718882,
0.0105662905,
-0.037195478,
0.0024064325,
-0.020038595,
0.009492317,
0.0028483623,
0.043172367,
-0.012520787,
-0.017610483,
0.0110866,
-0.0059535443,
-0.007070876,
-0.0069374633,
0.027536392,
0.021386065,
-0.0012507446,
0.005376534,
-0.022306614,
0.02552186,
0.007898035,
-0.013501371,
-0.029937822,
0.021799644,
0.03159214,
-0.012420728,
-0.0062303757,
0.0057067308,
0.05896844,
-0.026615845,
-0.033193093,
-0.0058434787,
0.0053798696,
0.04517356,
-0.022706851,
0.02550852,
-0.022573438,
0.012347351,
-0.004185825,
-0.029777726,
0.042078383,
0.0015917809,
0.00067123293,
0.028923886,
-0.007030852,
-0.015102324,
-0.123593576,
-0.038716383,
0.0034103636,
-0.0017710543,
-0.0130944615,
0.022093153,
-0.020612272,
0.009705778,
-0.005346516,
0.033433236,
0.0058034547,
-0.028683743,
0.0050463374,
-0.008611794,
0.024040978,
-0.012794283,
-0.0052664685,
0.000328112,
-0.031031808,
0.029324124,
0.0032486005,
0.009845861,
0.0073510427,
-0.008505063,
0.015195712,
-0.015249078,
-0.0403707,
0.014408577,
0.015529245,
0.008405004,
0.020839073,
-0.00408243,
0.015635975,
-0.005973556,
-0.009458965,
-0.00538654,
-0.009919238,
-0.015302443,
0.025241693,
-0.024614653,
-0.0049729603,
0.011493509,
0.0029350806,
0.005573318,
-0.000381894,
-0.0019111377,
-0.017863968,
0.016383087,
0.022199882,
-0.018544372,
-0.011273378,
-0.029564267,
-0.018224182,
-0.033833474,
0.020518882,
-0.0015842764,
-0.0035387734,
0.02740298,
-0.002668255,
-0.015702682,
0.0011440144,
-0.0105662905,
-0.0069374633,
-0.015889458,
0.007831329,
-0.0047728415,
-0.029564267,
-0.02101251,
0.0045994045,
-0.03201906,
0.008031448,
-0.0018527696,
-0.010612985,
0.0017910663,
-0.02750971,
-0.0037088746,
-0.018117452,
-0.025588566,
0.009539012,
-0.008525075,
-0.00020553902,
-0.022146517,
0.027563075,
-0.031645507,
0.037889224,
0.029564267,
0.0035287675,
0.0019695058,
0.004275879,
-0.0016518167,
-0.014702085,
0.0010931508,
-0.0010748066,
-0.0109198345,
-0.012327339,
0.014702085,
-0.029137345,
-0.010025969,
0.014702085,
0.023774153,
-0.018704468,
-0.022053128,
-0.052751403,
0.014355212,
-0.0031718882,
0.009945921,
0.015742704,
0.0032936274,
0.0066172727,
0.0011265039,
-0.010259441,
0.025708638,
-0.023027042,
0.0021863016,
-0.014555331,
0.0056233476,
-0.0056233476,
-0.006110304,
0.03265944,
0.03220584,
0.027376298,
0.03023133,
-0.012394045,
-0.00035000002,
-0.0072443127,
0.022053128,
-0.02688267,
0.011033235,
0.01568934,
0.023240503,
-0.01045289,
-0.025134964,
0.007918047,
-0.01725027,
-0.0033720073,
0.0016259679,
-0.0046794526,
-0.015115665,
0.020652294,
0.02855033,
0.000020767571,
0.03663514,
-0.030391425,
-0.02750971,
0.012560811,
0.011306731,
0.008625135,
0.011887076,
-0.032499347,
0.018851222,
-0.0134947,
0.0030784993,
0.01830423,
-0.007824658,
-0.008398333,
-0.010392854,
-0.002248005,
0.0167433,
0.0035921384,
-0.008658488,
0.016890055,
-0.018997977,
0.040610842,
0.014608697,
0.01766385,
0.01632972,
0.0155559275,
-0.023240503,
-0.020932462,
-0.0066773086,
-0.022039788,
-0.032979634,
-0.010592973,
-0.030978441,
0.02185301,
0.008871948,
0.00961906,
0.008818584,
-0.0014842169,
-0.010199405,
-0.00637713,
0.01777058,
0.009252175,
0.01087981,
-0.023934249,
0.0077446103,
0.0466411,
0.006570578,
-0.0014808816,
0.016289698,
0.018397618,
-0.007511138,
-0.009178798,
0.022373319,
0.0054298993,
0.0076912455,
0.01851769,
0.014795475,
0.007477785,
0.012874331,
0.014501967,
0.036048125,
0.0014133414,
0.01975843,
-0.015782729,
-0.03263276,
-0.010659679,
0.010813104,
-0.023147114,
-0.042238478,
-0.023147114,
0.004499345,
-0.008291603,
0.013394641,
-0.000074836214,
-0.016863372,
-0.023213819,
-0.00037105422,
-0.0003814771,
0.00669065,
-0.024374511,
0.037302207,
0.015115665,
0.01161358,
-0.0061269808,
-0.014421918,
0.021692915,
0.005753425,
0.016036212,
-0.014021681,
0.020452175,
0.008805241,
0.0015634308,
0.0062770704,
-0.018877905,
-0.013614772,
0.0029250747,
0.0004990471,
-0.00062370463,
0.010973199,
-0.035861347,
0.084316865,
0.006360453,
-0.034367125,
0.016649911,
-0.017810604,
0.012060513,
-0.008518404,
0.012981061,
0.0074444315,
-0.03626159,
0.018624421,
-0.019518286,
-0.002996784,
-0.029057298,
-0.03148541,
0.004832877,
-0.013741514,
0.0017810602,
-0.009919238,
0.024801431,
0.023827517,
0.005333175,
0.0017910663,
-0.0015692676,
-0.021132581,
-0.012667541,
0.03514092,
0.013027756,
0.009965933,
-0.033059683,
0.0039089937,
-0.0024347827,
-0.029617632,
-0.0074244197,
0.000553246,
-0.0167433,
-0.02017201,
-0.0140083395,
0.011787017,
0.013187851,
0.004172484,
-0.003070161,
-0.024401193,
-0.03265944,
-0.005029661,
-0.0061136396,
-0.019905183,
-0.018290889,
0.005990233
] |
Primary afferent fibers are originated from pseudounipolar sensory cells in dorsal root ganglia (DRG) and transmit external stimuli received in the skin to the spinal cord. Here we undertook a proteomic approach to uncover the polarity of primary afferent fibers. Lumbar spinal nerve segments, peripheral and central to DRG, were dissected from 5-wk-old Wistar rats and the lysates were subjected to large-sized 2-DE at pH 5-6. Among approximately 800 protein spots detected in the central and peripheral fractions, one of the unique spots in the peripheral fraction with MW of 60 | [
0.005264619,
0.026484257,
-0.014303111,
-0.027169194,
-0.027880993,
0.018775351,
0.007984225,
0.0014789953,
-0.011925974,
-0.03370968,
0.0049154353,
0.025812749,
-0.0089511955,
0.016116181,
-0.015498394,
0.017633788,
0.031480275,
0.020239238,
-0.00013388181,
0.030969927,
-0.019285696,
0.024214562,
-0.02583961,
-0.00015853874,
-0.01684141,
0.005774965,
0.008172247,
-0.028042154,
-0.011690946,
-0.028606221,
-0.0028723734,
-0.0066042766,
0.0032484178,
-0.007507454,
0.015834147,
0.009884591,
0.008675877,
-0.0066042766,
0.0037705149,
-0.0029445605,
0.023865378,
0.0059797745,
0.006856092,
-0.010515808,
0.004740843,
-0.014907467,
-0.00890419,
-0.017942682,
-0.006527053,
0.019836333,
0.02330131,
-0.0027515022,
-0.030002957,
0.0021169274,
-0.0069165276,
-0.019809471,
0.02412055,
0.017244313,
-0.00017186395,
-0.018573899,
-0.015498394,
0.015471534,
-0.020279527,
0.012409459,
-0.026014201,
0.00056322693,
0.012389314,
0.011469348,
0.0070844046,
-0.01956773,
0.024926359,
0.02230748,
-0.013188408,
-0.016129611,
0.042412415,
-0.0020531344,
-0.015055199,
0.000969489,
0.0014924255,
-0.003877956,
0.0069232425,
-0.017956112,
-0.011415628,
0.020360108,
0.012409459,
-0.0100591825,
-0.0064028245,
0.014034508,
-0.003233309,
-0.024510026,
0.0019792684,
0.014706015,
0.01874849,
0.0011801745,
0.0061610816,
-0.00934067,
0.0011356871,
0.025973912,
-0.006120791,
-0.026215654,
-0.02679315,
-0.007735767,
-0.0105023775,
-0.016371354,
0.0025366198,
0.022911837,
0.0059294114,
-0.017606927,
0.028874824,
-0.0037873024,
-0.008131957,
0.014356831,
0.023771366,
-0.030862486,
-0.00014720704,
-0.0074268733,
0.038598254,
-0.0051773232,
-0.013940496,
-0.008548291,
0.0082125375,
0.026860302,
-0.0019775897,
-0.022428352,
0.056567796,
0.025812749,
0.026940882,
0.00007119029,
-0.0113887675,
0.011684231,
-0.009327239,
-0.01874849,
0.028391339,
0.028955406,
-0.003975325,
-0.005919339,
-0.0018432882,
0.018157564,
-0.015538684,
-0.027827272,
0.036744893,
0.027746692,
-0.027773552,
-0.0053586303,
0.009656278,
0.03763128,
0.033467937,
0.013557737,
0.0016040637,
0.00072312966,
0.016371354,
-0.029009126,
-0.004059263,
-0.013040677,
-0.018426167,
0.012228152,
0.011375338,
0.0374164,
0.0025970554,
0.01159022,
-0.011737952,
-0.021810565,
0.004408447,
-0.023986248,
-0.010468802,
0.029788075,
0.007903644,
0.014397122,
0.010616534,
0.014209099,
-0.0045427484,
-0.0057279593,
0.006882952,
0.014934327,
0.003616068,
-0.008340124,
0.0023939244,
-0.009830871,
-0.037040357,
-0.014800026,
-0.018076982,
-0.01693542,
0.0023150223,
-0.0003386916,
0.0018181066,
-0.006657997,
0.021595683,
-0.026390247,
-0.007473879,
-0.03110423,
0.001071894,
0.0038981012,
-0.007507454,
-0.0076148952,
-0.6498044,
-0.017888961,
0.026161933,
-0.011798387,
0.019084245,
0.019406568,
0.0035757776,
-0.005200826,
-0.015417813,
0.0195543,
0.0040122573,
0.014974618,
-0.00031057224,
-0.03464979,
-0.012765358,
-0.0037503697,
-0.0023368462,
-0.012308734,
0.01880221,
-0.017956112,
-0.021434521,
0.00849457,
-0.0011591899,
0.016425075,
0.00045872357,
-0.00085449335,
0.030244699,
-0.031426553,
-0.010495663,
0.020910745,
-0.026497688,
-0.009186223,
0.012839224,
-0.0049053626,
0.05004074,
-0.02589333,
-0.0025802676,
0.018090414,
0.023422183,
0.045796815,
-0.025288973,
0.001938978,
0.015511824,
-0.013618173,
-0.019769182,
0.023583345,
-0.0037738723,
0.0023972818,
0.015552115,
-0.011482779,
0.0044050897,
-0.0072589964,
-0.030002957,
-0.010180054,
0.013060821,
0.006201372,
0.029841796,
-0.009004916,
-0.007326147,
0.014800026,
0.010898568,
0.028794244,
-0.001329585,
-0.0059663444,
0.0044353073,
-0.0010106189,
-0.040263593,
-0.0071515553,
0.024389153,
0.013228699,
0.029653773,
0.044856705,
-0.002251229,
-0.008024515,
0.00800437,
-0.0020564918,
-0.004334581,
0.0032903869,
-0.0063759643,
0.0069232425,
-0.018345585,
0.014786596,
-0.029895516,
0.006251735,
-0.0037637998,
-0.0073664375,
-0.017526347,
0.007655186,
-0.0043312237,
-0.018345585,
-0.005220971,
0.00800437,
-0.004824782,
-0.03204434,
-0.02668571,
0.0410694,
-0.0122012915,
0.016733969,
-0.0017509559,
-0.0127183525,
-0.0102069145,
-0.00421371,
-0.007574605,
-0.0140479375,
0.045098446,
-0.0030251415,
-0.022012018,
0.01780838,
0.021515101,
-0.03035214,
-0.010683685,
-0.018345585,
-0.008232682,
0.00050866697,
0.010717261,
-0.018170994,
0.000980401,
-0.0018197855,
-0.011825248,
-0.027343787,
0.014034508,
0.004045833,
0.0034951968,
-0.010065898,
0.018050123,
0.00938096,
-0.015713276,
-0.019406568,
0.0098443,
-0.02127336,
0.0033592165,
-0.0019272267,
0.014491132,
-0.013174978,
0.013007101,
0.016801119,
0.019151395,
0.0053351275,
-0.008272973,
-0.045205887,
-0.045984834,
-0.009495117,
-0.00028266272,
-0.027531808,
0.0064229695,
-0.03832965,
-0.031856317,
0.017660648,
0.016492225,
-0.0054358537,
-0.016881699,
-0.022106027,
-0.026537977,
0.0030251415,
0.0077021914,
-0.010166625,
0.00940782,
-0.019084245,
0.005506362,
-0.024281712,
-0.015686415,
0.018479887,
-0.017888961,
0.047489014,
-0.020373538,
-0.021918006,
-0.009031776,
0.029277729,
0.0016317633,
-0.030540163,
-0.0017559922,
0.0009963493,
-0.013007101,
0.013577882,
-0.032259222,
0.01029421,
0.0009090533,
-0.00080706814,
-0.021770274,
-0.008272973,
0.009622703,
-0.01374576,
0.0025701951,
0.0039182464,
0.04004871,
0.012429604,
0.020010924,
0.02228062,
-0.0077894875,
0.013342855,
-0.017056292,
0.004072693,
-0.027303496,
0.01111345,
-0.042976484,
0.00094598625,
0.038141627,
0.0038477383,
-0.011684231,
0.029546332,
0.020051215,
-0.015766997,
-0.0020799947,
0.0051672505,
0.019876624,
-0.025665019,
0.006187942,
-0.021031616,
0.010905283,
0.00011531043,
-0.006406182,
-0.0131615475,
-0.010791126,
-0.019473718,
-0.024657756,
0.04195579,
-0.014679154,
0.018332155,
-0.001945693,
-0.011194031,
-0.00050908665,
0.001212071,
0.028176457,
0.02134051,
-0.021904577,
0.033172473,
-0.008178961,
0.018063553,
0.001910439,
-0.015256652,
0.0043547265,
0.007675331,
0.0205347,
0.024684617,
-0.018587328,
0.0126444865,
0.00020470488,
-0.0077021914,
0.038490813,
0.011872253,
0.025060661,
0.03929662,
-0.0042540003,
0.01880221,
-0.016492225,
-0.027437799,
0.0067587234,
0.0015184464,
-0.0241877,
0.015619265,
-0.008078235,
0.007910359,
-0.004415162,
-0.0056104455,
0.008333408,
-0.0019624808,
0.014571713,
0.023677357,
0.013356285,
0.03534816,
0.0042741457,
-0.0058958363,
0.0097637195,
-0.030943068,
0.014786596,
0.0036496434,
-0.008850469,
0.011543214,
-0.028874824,
0.009857731,
-0.018359017,
-0.008642302,
0.0029126639,
-0.01289966,
0.017083151,
0.024590606,
0.01422253,
-0.003196376,
0.013188408,
0.013363,
-0.045823675,
-0.010529238,
0.016290773,
0.00646326,
-0.0024409299,
-0.013483872,
-0.02491293,
0.013275704,
-0.008803464,
-0.012577336,
0.0009056958,
-0.019030524,
0.0052478313,
-0.017110012,
0.0035422023,
0.00222269,
0.015296942,
-0.014088228,
0.021985156,
-0.01201327,
0.010307641,
-0.0059361267,
-0.03722838,
-0.0071515553,
0.036718033,
0.013651748,
-0.010287495,
-0.0019943775,
0.019715462,
-0.022952128,
0.008393845,
0.0071649854,
-0.00379066,
0.019003663,
-0.0017610285,
0.002288162,
0.0057850373,
0.0101330485,
0.030889347,
0.0036261408,
-0.019890053,
-0.04034417,
-0.007648471,
-0.01161708,
0.011073159,
0.03110423,
0.004348011,
0.018896222,
0.00200445,
-0.010099473,
-0.014128518,
-0.013457011,
0.025396414,
-0.01156336,
0.01070383,
0.003998827,
0.00980401,
0.005875691,
0.020239238,
0.0010114582,
-0.00804466,
-0.027276637,
0.018990234,
0.0031711943,
-0.0070844046,
0.022092598,
0.02495322,
0.035536177,
-0.011294757,
0.0062718806,
0.012187862,
0.019728892,
-0.001648551,
0.0043513686,
-0.009004916,
0.023032708,
0.002766611,
-0.00052671373,
-0.011737952,
-0.003310532,
0.0055365795,
0.0031779094,
0.01963488,
0.008286403,
0.010878422,
0.01959459,
0.0066512823,
-0.026430536,
0.0037268668,
-0.007017254,
-0.0031157949,
-0.009918166,
0.020360108,
-0.0017157018,
0.01244975,
-0.023261022,
0.018265005,
-0.009521977,
0.0032920658,
-0.007883498,
-0.0020380253,
-0.008763174,
-0.010039038,
-0.025651587,
0.007769342,
0.0021085336,
0.018788781,
-0.017888961,
-0.021246498,
-0.0053351275,
-0.005832043,
0.015014908,
-0.019312557,
0.00010891013,
-0.027196055,
-0.013718899,
-0.025275543,
-0.0025097595,
0.019903483,
0.013463726,
0.014974618,
-0.008024515,
0.024724908,
0.025382984,
0.0045796814,
-0.020776443,
-0.0026172006,
-0.014356831,
0.003412937,
0.028015295,
0.017204024,
-0.0053049093,
0.0020951035,
-0.03843709,
0.0107239755,
-0.018372446,
0.0025584437,
0.007903644,
0.005519792,
0.0036932915,
0.046978667,
0.022441782,
-0.008884044,
-0.017606927,
-0.0030872559,
-0.036825474,
0.0020128437,
-0.012261728,
-0.0023116646,
-0.01288623,
-0.0006748651,
-0.009622703,
-0.0034985542,
-0.012369169,
-0.010159909,
-0.026121642,
0.010233775,
0.0026860302,
-0.01685484,
-0.004287576,
-0.0049926587,
0.015431243,
0.020763014,
-0.022992417,
-0.0024644327,
-0.0071649854,
0.04434636,
-0.00037835253,
-0.022401491,
0.039323483,
0.00035086268,
-0.0012859369,
-0.024671188,
-0.03738954,
0.00014899073,
0.036153965,
0.024671188,
-0.045205887,
-0.008434135,
0.0025651588,
-0.015270081,
0.02132708,
-0.02128679,
0.002513117,
-0.010697115,
0.0019843047,
-0.0030922922,
0.013678608,
0.033306774,
-0.030029817,
-0.023569915,
0.022025447,
-0.017392045,
0.012443035,
-0.0107239755,
0.0020682432,
0.00799094,
-0.0042674304,
-0.040612776,
-0.031695157,
-0.012328878,
-0.027330358,
0.028283898,
0.027222915,
0.028821103,
-0.0063994667,
-0.0034297248,
0.034461766,
-0.01067697,
0.01606246,
-0.011133595,
0.013967357,
-0.02488607,
0.036341988,
0.009374245,
0.0022478714,
0.013342855,
-0.012046846,
0.010126334,
0.023543054,
-0.011335047,
-0.017163733,
0.0073462925,
-0.0153372325,
-0.032366663,
0.017351754,
0.0038510957,
0.030056678,
-0.028633082,
0.0019876624,
0.009199653,
-0.0204004,
-0.0063591762,
-0.019715462,
0.037040357,
-0.014021077,
0.036127105,
-0.0007197721,
0.020078076,
0.008098381,
-0.025409846,
0.0017224168,
0.020964466,
0.007211991,
-0.009548837,
-0.004989301,
0.023932528,
-0.023569915,
0.018788781,
-0.001997735,
-0.00557687,
-0.016881699,
-0.035401877,
-0.0019339417,
-0.025047231,
-0.019379707,
-0.027115474,
-0.0393772,
-0.0064162547,
0.005570155,
-0.014195669,
0.01424939,
-0.022065738,
-0.040424753,
0.028901685,
0.005063167,
0.041257422,
-0.030567024,
0.0038443806,
0.023650495,
-0.005338485,
-0.0032551328,
-0.004311078,
-0.006251735,
-0.00598649,
0.032930728,
-0.016451934,
-0.019984065,
-0.027585529,
-0.009716714,
0.01696228,
-0.002026274,
-0.022495503,
0.024456304,
0.018923081,
0.014235959,
0.017069722,
0.005197468,
-0.03467665,
0.03309189,
-0.027088614,
0.013477156,
-0.011200746,
-0.00037793283,
-0.028122736,
0.04010243,
-0.020897314,
0.029089706,
-0.0037235094,
-0.004945653,
-0.009649564,
-0.017996402,
-0.002148824,
0.000019345187,
-0.0007126374,
0.012530331,
-0.009172793,
0.00889076,
0.0020313102,
0.0124228895,
0.008810179,
0.0022713742,
-0.014719445,
0.04354055,
-0.024442874,
0.0023788156,
0.0041868496,
0.0013228698,
0.011368623,
-0.0026457396,
-0.0008956232,
-0.016331064,
-0.033253055,
-0.007655186,
0.011120165,
0.012711638,
-0.0066512823,
0.000984598,
-0.0153372325,
0.0008863899,
-0.036906052,
-0.0033357136,
-0.007829778,
-0.024469735,
-0.014397122,
0.010408367,
0.013718899,
0.020360108,
-0.0062047294,
0.011623795,
-0.011697661,
0.0077021914,
-0.00889076,
0.013356285,
-0.007480594,
0.025987342,
-0.03373654,
0.019191686,
-0.014679154,
-0.03201748,
0.018909652,
-0.005519792,
-0.04160661,
0.014141949,
0.015417813,
0.0021874357,
-0.011247751,
-0.020051215,
-0.0075275996,
0.006070428,
0.009038491,
0.0035287722,
-0.017700939,
-0.005711172,
-0.00560373,
-0.01697571,
0.0047844914,
-0.018506749,
0.00807152,
-0.006224875,
-0.027961574,
0.024698047,
-0.016586237,
-0.01958116,
-0.012691492,
0.010086043,
-0.035133276,
-0.00033764238,
0.0026138432,
0.0068158014,
-0.01689513,
0.008816894,
0.011737952,
-0.023046138,
-0.012281873,
-0.009602558,
-0.0035824927,
0.008272973,
-0.022602944,
0.002120285,
-0.0022411563,
-0.001945693,
-0.04176777,
0.011697661,
-0.037899885,
0.03760442,
0.0049993736,
0.011751382,
0.000826374,
0.008172247,
-0.026175363,
-0.023207301,
0.007400013,
0.010656824,
0.013275704,
0.02309986,
-0.0073597226,
-0.008413989,
0.012731783,
0.017271174,
-0.009931597,
-0.0059730597,
0.020736152,
-0.005244474,
0.02152853,
-0.005150463,
-0.035536177,
-0.037067216,
0.029009126,
-0.014235959,
-0.0038242354,
0.012698207,
-0.007910359,
0.0067083603,
-0.021904577,
0.02410712,
0.019661741,
-0.0032232362,
0.0038175203,
-0.041311145,
0.0047240555,
0.00040982943,
0.0017979614,
0.0014554926,
-0.00977715,
0.022911837,
0.003172873,
0.007393298,
-0.017083151,
-0.011502924,
0.0027447871,
-0.012872799,
0.026323095,
0.010220345,
-0.01291309,
-0.0008687629,
0.016519085,
0.00797751,
-0.03384398,
-0.015807288,
-0.015216361,
-0.0019473719,
0.020682432,
0.015753567,
0.01791582,
-0.014329971,
0.0074201585,
-0.030620744,
-0.00041402638,
-0.028069016,
0.003998827,
-0.025275543,
0.023529625,
-0.0012741856,
-0.023905668,
-0.0023049496,
-0.002106855,
-0.013356285,
-0.012167716,
-0.019164825,
-0.00649012,
-0.03204434,
-0.0028706947,
0.0066177067,
-0.0037604421,
-0.004754273,
-0.024698047,
-0.0030402504,
-0.03287701,
0.011892399,
0.16889757,
0.002207581,
0.011254466,
0.0029798148,
-0.006493478,
0.0089511955,
0.009938312,
0.00024132302,
-0.011845393,
0.021555392,
0.0159013,
-0.005832043,
-0.007970794,
-0.0009678102,
0.033494797,
-0.009239944,
-0.02483235,
0.010549383,
-0.0068896674,
-0.012194577,
0.006406182,
-0.015444674,
0.010556098,
-0.002790114,
0.037201516,
0.019057384,
-0.026175363,
-0.014088228,
0.011529785,
0.024254853,
-0.006083858,
0.0029798148,
0.0032299513,
0.012986956,
-0.008884044,
0.014840317,
-0.015350662,
0.008662447,
0.01602217,
0.0041868496,
0.029035985,
-0.015713276,
-0.0048180665,
-0.0014571714,
-0.028633082,
0.011281326,
0.010146479,
-0.025705308,
-0.03123853,
0.041230563,
-0.033226192,
0.03314561,
0.01787553,
0.0032937445,
0.0005237759,
-0.02852564,
0.02050784,
0.024845779,
0.0070709744,
0.021689693,
-0.03464979,
0.023919098,
-0.020078076,
0.022549223,
-0.0026759575,
0.009575698,
0.0010559456,
-0.003965252,
0.021864286,
-0.030755045,
0.022965558,
0.00038422822,
-0.010932143,
0.015350662,
-0.017647218,
-0.015632695,
0.0061845845,
0.016572805,
0.025087522,
0.009649564,
0.009589127,
-0.027961574,
-0.016438505,
0.0135308765,
-0.025476996,
-0.0101330485,
0.011335047,
0.03918918,
-0.0094682565,
-0.005902551,
0.0032668842,
-0.00580854,
-0.0033592165,
-0.02403997,
0.003928319,
-0.018211285,
-0.002832083,
0.008125241,
-0.019111104,
-0.013248844,
-0.01157679,
0.07370467,
0.019352848,
-0.007413443,
-0.0395115,
0.008924335,
0.009575698,
0.012610911,
-0.00092248345,
-0.016693678,
0.0071717007,
-0.0021001399,
0.0069769635,
-0.024456304,
0.00043186327,
0.012577336,
0.01975575,
-0.039726388,
0.0029093064,
-0.013900206,
-0.01112688,
-0.018936513,
0.0049557257,
0.010018893,
-0.0036664312,
-0.0140076475,
-0.008763174,
-0.007124695,
0.024510026,
-0.014074798,
-0.004247285,
-0.015740138,
0.0045192456,
0.010744121,
-0.025181532,
0.022656664,
-0.013483872,
-0.0008889081,
-0.01427625,
0.0006459063,
-0.006607634,
-0.022468641,
0.043379385,
-0.010361361,
0.002286483,
0.008460995,
0.01514921,
0.039672665,
-0.01422253,
0.0064229695,
-0.0014538139,
-0.01608932,
0.01607589,
0.0063356734,
0.010737405,
-0.010777696,
-0.0222269,
-0.0059730597,
-0.009004916,
0.0025080806,
0.0007814669,
-0.0060536405,
0.0028471919,
-0.001395057,
-0.0069098123,
0.0011600293,
-0.17029431,
0.024227992,
0.010495663,
-0.036906052,
0.028794244,
0.01886936,
-0.0037671572,
0.012946665,
-0.008172247,
0.022549223,
0.0318026,
-0.009031776,
-0.018453026,
-0.045716234,
-0.007480594,
-0.0029009127,
-0.018291865,
0.024698047,
0.0041801343,
0.026981173,
0.009945027,
-0.019352848,
0.008857184,
0.006775511,
0.017620359,
0.016465364,
-0.00938096,
-0.0024661114,
-0.011032869,
-0.035804782,
0.008561721,
0.00799094,
0.035321295,
-0.026833441,
0.032715846,
0.015055199,
-0.023005849,
-0.023395322,
0.0080648055,
0.013739044,
0.033065032,
0.018775351,
0.02048098,
0.009495117,
-0.00038359867,
0.023905668,
-0.00082721334,
-0.0011264539,
0.0023620278,
-0.02769297,
0.007943934,
0.0035455597,
0.022025447,
0.022119459,
0.036476288,
0.02941203,
0.007829778,
0.002853907,
0.010609819,
-0.007218706,
0.0075007393,
-0.017512916,
0.026403677,
0.01514921,
0.0152297905,
-0.004609899,
0.0023721005,
0.017714368,
-0.03561676,
0.0119796945,
-0.031507134,
-0.025973912,
0.006493478,
-0.029304588,
0.009266804,
-0.0053351275,
-0.011791673,
-0.008622156,
-0.017633788,
-0.01120746,
-0.01422253,
0.013201838,
0.010623249,
-0.004287576,
-0.031587716,
0.010455373,
0.00056322693,
0.013268989,
0.027504949,
-0.01780838,
0.008299833,
-0.017700939,
0.00799094,
-0.009548837,
0.019728892,
0.02324759,
0.00041759375,
-0.001238092,
-0.00799094,
0.016586237,
0.019728892,
0.009293664,
-0.024698047,
0.020615282,
-0.008910905,
-0.0012741856,
-0.027061753,
0.02057499,
0.009004916,
-0.0066915727,
0.005231044,
0.0062483777,
-0.0041969223,
0.010918712,
-0.003609353,
0.024684617,
0.017687509,
-0.017445765,
0.029035985,
-0.017754659,
0.036906052,
-0.009072067,
-0.012181147,
0.011798387,
0.0010517486,
-0.011234321,
-0.124524355,
-0.009602558,
0.01516264,
0.018170994,
0.004297648,
0.0045091733,
-0.004713983,
0.03301131,
-0.034408048,
0.026269374,
-0.0057413895,
-0.02496665,
0.0027095329,
-0.0056171604,
0.010911997,
-0.020413829,
0.01595502,
0.00019987841,
-0.029626913,
0.027128905,
-0.00842742,
0.008413989,
-0.0025080806,
0.011623795,
0.0033441074,
-0.00072984473,
-0.040263593,
0.023610204,
0.0002038655,
0.0031644793,
0.00931381,
-0.004828139,
0.04450752,
0.005949557,
-0.014517993,
-0.0067721535,
-0.006006635,
-0.01289966,
0.047945637,
0.0071582706,
0.0028656584,
0.020763014,
0.011281326,
-0.0050665243,
0.0061745117,
0.0015453068,
-0.012798933,
0.020319818,
0.018506749,
-0.024174271,
-0.019742321,
-0.029116567,
-0.014397122,
0.0014697621,
0.013752474,
-0.00083224964,
0.0053821327,
0.018896222,
-0.008850469,
-0.0059529142,
-0.0035589898,
-0.0050430214,
0.012228152,
0.012610911,
0.01678769,
-0.0012657917,
-0.019057384,
-0.01608932,
0.015417813,
-0.027142335,
0.0060402104,
-0.026833441,
-0.0056809536,
-0.0052981945,
-0.024617467,
0.011664086,
-0.0178621,
0.0015881154,
0.005432496,
-0.008011085,
-0.018775351,
-0.022186609,
0.011294757,
-0.024456304,
0.0039316765,
0.015834147,
0.012866084,
-0.012684777,
0.0046669776,
-0.031023648,
-0.012443035,
0.041579746,
0.008790034,
-0.0015537005,
-0.0031460128,
0.012295303,
0.008803464,
0.017714368,
0.0036865764,
-0.0018768635,
-0.014853747,
-0.0044487375,
-0.052001543,
0.0071582706,
0.014840317,
-0.015646126,
0.020803304,
-0.00040857037,
0.026631989,
0.00018770734,
0.002875731,
0.004932223,
-0.015270081,
0.0014764772,
-0.009951741,
-0.002825368,
-0.038249068,
-0.051732942,
0.038625114,
-0.00889076,
0.014826886,
0.004371514,
0.0015956698,
0.005533222,
0.0001101692,
0.01025392,
-0.03464979,
-0.001329585,
-0.04386287,
0.025920192,
0.0006421291,
-0.0005225168,
-0.007883498,
-0.04292276,
-0.021770274,
0.020051215,
0.013705469,
-0.020924175,
-0.0055097193,
0.013020531,
0.016519085,
0.015310372,
-0.03467665,
-0.027988434,
-0.0073664375,
-0.02312672,
0.000055032142,
0.002221011,
-0.02410712,
0.005613803,
0.0005976417,
-0.00687288,
0.03295759,
0.0032014123,
-0.00089730194,
-0.02033325,
-0.025490426,
0.017969541,
-0.012738498,
-0.008615442,
0.013980787,
-0.017378615,
0.038705695,
0.011395483,
0.029841796,
-0.009589127,
-0.024093691,
-0.0039115315,
-0.014732875,
-0.0067956564,
-0.02049441,
-0.014947758,
-0.018493317,
0.021716554,
0.017190592,
0.0034750516,
0.0054157083,
-0.0093943905,
-0.0058051827,
-0.008178961,
-0.008313264,
-0.008749743,
0.019352848,
0.005133675,
-0.015780427,
0.009461541,
0.044238918,
0.012993671,
-0.009421251,
0.017123442,
-0.018520178,
0.00602678,
-0.00055273465,
0.012731783,
0.018909652,
0.01872163,
-0.0006589168,
-0.0013883419,
0.0073462925,
0.00403576,
0.026000772,
0.0075477445,
0.013007101,
0.008353554,
0.009931597,
-0.026699139,
-0.0054660714,
0.025597867,
-0.043997172,
-0.03454235,
-0.01692199,
-0.0017157018,
0.0074403035,
0.00043941775,
-0.009481686,
0.0056843115,
-0.019728892,
0.0057481043,
-0.0001051329,
-0.004247285,
-0.00014458397,
-0.007185131,
0.0124228895,
0.03373654,
-0.02399968,
0.0010198521,
-0.005090027,
0.013859916,
0.025732169,
-0.00085952965,
0.016519085,
0.0010316034,
0.01424939,
-0.015740138,
-0.021595683,
-0.020239238,
0.0102069145,
-0.012107281,
-0.0004918793,
0.020628711,
-0.026376816,
0.08036602,
0.0098443,
0.0044823126,
-0.0022545867,
0.0005749783,
0.0052108984,
-0.022952128,
0.007688761,
-0.0015738457,
-0.031587716,
0.026497688,
-0.006261808,
0.024281712,
-0.037040357,
-0.013289134,
0.024711477,
-0.0019205116,
0.028982265,
-0.008131957,
-0.020360108,
0.03209806,
-0.013450296,
0.014974618,
0.012140856,
-0.022750676,
0.0043513686,
0.006469975,
-0.006644567,
-0.0048986473,
-0.024926359,
0.006456545,
0.004250643,
-0.052834213,
-0.0041230563,
-0.000700886,
-0.025584437,
-0.011502924,
-0.018197855,
-0.01767408,
0.02852564,
-0.0011037905,
0.040612776,
-0.015014908,
-0.0021286788,
-0.003820878,
-0.0048046364,
-0.015323802,
-0.019070813,
-0.014880607
] |
The FASTA package of sequence comparison programs has been modified to provide accurate statistical estimates for local sequence similarity scores with gaps. These estimates are derived using the extreme value distribution from the mean and variance of the local similarity scores of unrelated sequences after the scores have been corrected for the expected effect of library sequence length. This approach allows accurate estimates to be calculated for both FASTA and Smith-Waterman similarity scores for protein/protein, DNA/DNA, and protein/translated-DNA comparisons. The accuracy of the statistical estimates is summarized for 54 protein families using FASTA and Smith-Waterman scores. Probability estimates calculated from the distribution of similarity | [
-0.028132547,
-0.022020334,
-0.022129482,
-0.010464434,
-0.008813591,
0.026699996,
-0.0043863305,
-0.0053618285,
-0.016767653,
-0.019441744,
-0.008240571,
0.017818188,
-0.0004167611,
0.018391209,
0.002167584,
0.0030833925,
0.013766119,
-0.02069693,
-0.009161496,
0.016180988,
-0.0008723204,
0.0312978,
-0.014407356,
-0.021542817,
0.002512078,
0.03380817,
0.011903805,
-0.017217882,
-0.014639293,
-0.018786864,
0.030533772,
-0.016726723,
-0.034353904,
0.010675905,
-0.010403039,
-0.010914664,
-0.0061292658,
-0.016508428,
0.028869286,
-0.02176111,
0.0044477256,
0.02294808,
0.0033647863,
0.002319366,
0.001522084,
-0.014325496,
0.007838093,
-0.0045739263,
-0.011596831,
0.021733824,
0.019318955,
0.010123351,
-0.016576646,
0.00815189,
0.0030782763,
-0.00040397045,
0.011583187,
-0.033126004,
-0.012776978,
0.009523044,
-0.015062236,
0.011439932,
-0.017176952,
-0.0070945313,
-0.008070029,
-0.014707509,
-0.014543789,
0.0069342223,
0.01315217,
0.038583335,
0.033016857,
0.035800096,
-0.024175981,
0.02442156,
0.02769596,
-0.0080291,
-0.004352222,
0.011276212,
-0.0030083542,
0.0007768171,
0.003765559,
-0.014148133,
0.022211341,
-0.0012432485,
0.0012236361,
0.02073786,
-0.002982773,
0.04147572,
-0.03519979,
-0.01568983,
0.027627742,
0.02704108,
-0.010089242,
-0.001966345,
-0.027204799,
-0.014734796,
0.008336075,
0.03137966,
0.0050991946,
-0.038583335,
-0.0114467535,
0.014816656,
-0.003519979,
-0.015908122,
-0.024517063,
0.0012645661,
0.001384798,
-0.025867753,
-0.021815684,
-0.0019407637,
-0.035254363,
0.0005124776,
0.014161776,
0.010348465,
-0.008070029,
-0.019264381,
0.058502596,
-0.014612006,
-0.008547546,
-0.002065259,
0.0037996673,
0.001770222,
0.035636377,
-0.008281501,
0.022429634,
0.016044555,
-0.022020334,
-0.014680223,
-0.0008185998,
-0.003884938,
0.03348073,
0.027491309,
0.014721152,
0.0054675643,
-0.06063096,
0.011344428,
-0.00016318701,
-0.024476133,
-0.011869697,
-0.015389676,
0.015580682,
0.029496878,
-0.021774754,
-0.02740945,
-0.0222932,
0.028650992,
0.021460958,
0.018036481,
0.008834056,
-0.02241599,
0.028296266,
-0.013186278,
-0.01266101,
-0.002217041,
0.0027678905,
-0.009202426,
0.0027423094,
-0.0055528353,
-0.0345722,
-0.02495365,
-0.029524166,
0.023875827,
-0.002228979,
-0.0024813805,
0.01000056,
0.019755542,
-0.014925803,
-0.020464994,
-0.019810114,
-0.021379098,
-0.016535716,
0.020301275,
-0.03994767,
0.015171383,
0.00091069227,
0.00052100467,
0.0022545601,
0.028050685,
-0.028732853,
-0.029578738,
0.013295425,
0.017777259,
0.016835868,
0.018991515,
0.0027303714,
-0.0032709884,
0.024244197,
0.0005849578,
0.026891002,
0.00064208923,
0.013493253,
-0.006756859,
-0.00540958,
-0.005812058,
-0.6387261,
-0.010355287,
-0.007844915,
-0.031843532,
0.026290696,
0.014229992,
0.0011153423,
0.034272045,
0.00038776902,
0.031788956,
-0.030451912,
0.013043023,
-0.006739805,
-0.03326244,
-0.018513998,
-0.041366577,
0.0032130042,
-0.026195193,
0.020260345,
-0.0018333225,
-0.045022987,
0.03675513,
-0.0012833257,
0.011978843,
0.009256999,
0.0074765445,
-0.000610539,
-0.04264905,
0.0021317704,
-0.0077289464,
-0.018759578,
0.010689549,
0.0006079809,
0.03544537,
0.050016448,
-0.011692334,
0.018336635,
0.003581374,
0.014953089,
0.009270643,
-0.021802042,
-0.018582216,
0.020260345,
0.022184053,
-0.0058768643,
0.0090182405,
0.015116809,
-0.0010582107,
-0.01262008,
-0.020860652,
0.0001717141,
-0.0053584175,
-0.009072814,
0.0119652,
0.004191913,
0.016317422,
0.041011848,
-0.015703473,
0.010928307,
0.010021025,
-0.007524296,
-0.001481154,
0.0014717742,
-0.01967368,
-0.012067525,
-0.0075038313,
0.011972022,
0.011705977,
0.019032445,
-0.0131931,
0.016276492,
0.017777259,
0.011153422,
-0.0030390518,
0.003126028,
0.036864277,
0.018936941,
0.0067841457,
-0.009516222,
0.02421691,
0.016890442,
-0.005757485,
-0.01938717,
-0.019046089,
0.013090774,
0.006961509,
-0.021242665,
0.022020334,
0.0072718947,
0.0066170148,
0.01368426,
0.003888349,
-0.007974526,
-0.036700558,
-0.009502579,
0.004256719,
-0.020287631,
-0.020396778,
0.00733329,
-0.042021457,
-0.015539752,
-0.0025171943,
0.026508989,
0.0035643198,
0.000692399,
0.005569889,
-0.0075993347,
0.028978432,
0.017490748,
0.027545882,
0.0047649327,
-0.02172018,
0.00046728403,
-0.028459985,
-0.011931092,
-0.029742459,
0.015212312,
0.0063953106,
-0.012401787,
-0.012299461,
-0.010171102,
0.0014163482,
0.002012391,
-0.0062008933,
-0.00241828,
0.01466658,
0.0026809142,
-0.024244197,
-0.01863679,
-0.027518597,
0.0050923727,
-0.0038337756,
0.023343736,
-0.015144096,
0.012265353,
0.009256999,
0.0027900608,
0.01147404,
-0.0028992076,
-0.013124883,
-0.017709041,
0.013902553,
-0.010443969,
-0.029878892,
-0.028378125,
-0.019769184,
-0.033671737,
0.000940537,
0.028896572,
0.0011136368,
-0.004839971,
0.007926774,
-0.037546445,
-0.005733609,
0.0068523623,
-0.0015954169,
-0.013513718,
-0.03749187,
-0.008261036,
-0.030752065,
-0.01151497,
0.015635256,
-0.009277464,
0.0000040770105,
-0.0021027783,
-0.016426569,
0.0073810415,
0.00016936914,
-0.021842971,
-0.021365454,
0.0026689763,
-0.022852577,
-0.00019217908,
0.018745935,
-0.014448286,
0.02859642,
-0.01069637,
0.011016989,
-0.010021025,
-0.011248926,
0.019359885,
-0.021570105,
-0.02036949,
-0.010682727,
0.043413077,
0.008595298,
0.011712799,
-0.0031004467,
-0.011064741,
0.012633723,
0.005314077,
-0.014980376,
-0.0045057097,
0.011644582,
-0.009461649,
0.008759018,
0.0148575865,
0.018745935,
0.008595298,
0.020765148,
0.029933466,
0.0047512897,
0.00327781,
-0.0039736195,
0.000089960704,
-0.024885433,
0.025513027,
-0.024776287,
0.010689549,
0.005576711,
-0.014448286,
-0.016453855,
-0.04068441,
-0.017954621,
0.016849512,
-0.0047478788,
-0.022252271,
0.0011818535,
0.025635816,
0.030288192,
-0.006003065,
-0.009884592,
0.046605613,
-0.016221918,
0.0046046237,
-0.012183493,
-0.00565516,
0.029851606,
0.0069478657,
0.0040418366,
0.023452884,
0.01225171,
0.0053686504,
-0.003356259,
0.038010318,
-0.012299461,
0.026945576,
-0.014843943,
0.028841998,
-0.0016175873,
-0.0076197996,
-0.0016832458,
0.030561058,
-0.01695866,
0.018159272,
-0.016808582,
0.017586252,
0.0243397,
0.0073742196,
0.010246141,
-0.011289855,
0.010259784,
-0.011753729,
0.012183493,
-0.002769596,
-0.021829328,
0.013206743,
-0.00044895083,
0.04142115,
0.020028409,
-0.00056747725,
0.008990955,
-0.0011315437,
-0.0019390582,
0.021815684,
-0.019196166,
-0.020505924,
-0.02491272,
-0.007947239,
-0.010853269,
-0.0044920663,
-0.015416962,
-0.00025432018,
-0.010130173,
0.013486431,
0.0011554195,
0.0020601428,
0.029878892,
0.009939166,
-0.012306283,
-0.037873883,
-0.03282585,
0.03462677,
0.012565507,
-0.007967705,
0.020096624,
-0.022170411,
0.00585981,
-0.010027847,
0.018827794,
-0.004171448,
0.012033417,
0.0047376463,
-0.0070467796,
0.0061156224,
-0.0010991407,
0.017367959,
-0.022320487,
0.013732011,
0.007776698,
-0.0009584439,
-0.02196576,
-0.0023091335,
-0.020956155,
0.044859268,
0.016317422,
-0.005273147,
-0.014775726,
0.0172861,
0.01000056,
-0.0034926925,
-0.031215938,
0.0018333225,
-0.0007461196,
0.0055494243,
-0.020260345,
-0.018186558,
-0.008083673,
0.025540313,
0.016945016,
-0.0018674308,
-0.018814152,
-0.0052049304,
0.002474559,
0.033644453,
0.028814713,
0.0059826,
-0.006497636,
0.013636508,
0.0039599766,
-0.027191157,
0.013950305,
0.019605465,
-0.010573581,
-0.024025904,
0.004417028,
0.01151497,
0.010846447,
0.02008298,
0.040466115,
-0.013281781,
-0.042021457,
-0.014079916,
0.0026996739,
-0.00659655,
0.005290201,
0.0111261355,
0.02769596,
-0.002917967,
0.0006071282,
0.019509962,
0.013431858,
0.0002291653,
-0.018486712,
-0.013158992,
0.021924831,
0.0020055694,
0.021119874,
-0.001778749,
0.019496318,
-0.0007081741,
-0.022020334,
0.027491309,
0.0076402645,
0.006163374,
-0.0044477256,
0.0023858773,
0.019550892,
0.02257971,
0.0040657124,
-0.003871295,
0.025744963,
0.010389396,
-0.0068318974,
0.00066468597,
-0.026031474,
-0.011173887,
-0.014380069,
0.011010167,
-0.019237095,
-0.022934437,
0.0041987346,
-0.02438063,
-0.024189623,
-0.018623145,
-0.0040077283,
0.029305872,
-0.005372061,
-0.014803013,
-0.0074560796,
-0.013049845,
-0.016317422,
-0.011371715,
-0.020055695,
-0.0063646133,
-0.035663664,
-0.008990955,
-0.02237506,
0.009209247,
-0.0032095932,
0.008295145,
-0.017640825,
-0.014229992,
-0.006954687,
-0.005412991,
-0.005211752,
-0.0045909802,
-0.03146152,
-0.007449258,
0.018445782,
-0.01065544,
-0.017313385,
-0.0077494113,
-0.018077413,
0.011003345,
0.022470564,
0.0055664787,
0.0031294387,
0.018022839,
0.014816656,
0.011876519,
0.042594474,
0.013329533,
-0.018036481,
0.023152731,
-0.043031063,
-0.0068046106,
-0.015253243,
0.013963948,
-0.014107203,
-0.015662542,
-0.019455388,
0.0049798153,
-0.022647927,
-0.0031328495,
-0.01663122,
0.015703473,
0.025581243,
0.043112922,
0.024189623,
0.01417542,
0.004355633,
-0.007326468,
0.000920072,
-0.01659029,
-0.005651749,
0.018841438,
0.0030987412,
-0.009488936,
-0.0009123977,
0.00741515,
-0.007947239,
-0.010989702,
0.004451136,
-0.004191913,
0.024967294,
0.010403039,
0.0070194933,
0.005539192,
-0.0098231975,
0.014325496,
0.004403385,
-0.03064292,
-0.010894199,
0.012613258,
-0.011201174,
-0.0046557863,
0.0009968157,
0.00026327363,
-0.017149666,
-0.015089523,
-0.016644862,
0.004355633,
0.01634471,
-0.004880901,
-0.011590009,
-0.02589504,
-0.015307816,
0.002036267,
-0.02421691,
-0.013691082,
0.01499402,
0.025744963,
0.030561058,
0.025963256,
-0.019700969,
-0.01139218,
0.029524166,
-0.0005457332,
-0.019905617,
-0.0072718947,
-0.0046933056,
0.010928307,
-0.0018571983,
0.053017978,
-0.0041202856,
-0.0002961029,
-0.0125859715,
0.043986093,
0.03877434,
0.009256999,
-0.03413561,
0.012626901,
-0.039592944,
0.027150227,
0.007708481,
-0.003543855,
0.026945576,
-0.03618211,
-0.012244889,
0.005068497,
-0.0083701825,
0.014953089,
-0.00007349278,
0.020587785,
-0.0028292856,
0.027641386,
0.0065829065,
0.011590009,
-0.01262008,
-0.015812619,
-0.033071432,
0.0041782698,
0.033071432,
-0.023180017,
0.041557584,
-0.0028497505,
0.0000043601362,
0.0016371995,
-0.0036086608,
-0.033699024,
-0.009393432,
0.02204762,
0.0025871163,
0.0052015195,
-0.010423504,
-0.021870257,
-0.03225283,
-0.017313385,
0.00043552066,
0.013500075,
0.005351596,
-0.0048297388,
-0.026863717,
0.023493813,
0.0012287524,
0.038419615,
0.00042145097,
0.016603932,
0.022074908,
0.00015807076,
-0.03757373,
-0.00508214,
0.018950585,
0.02462621,
0.012681475,
0.017067805,
-0.017040519,
-0.013793406,
0.019046089,
-0.012347213,
-0.03405375,
-0.041011848,
0.02470807,
-0.009386611,
0.015239599,
-0.021365454,
0.028569132,
-0.029251298,
0.038283184,
-0.0021744056,
0.013759298,
0.0046728402,
-0.0009277464,
0.0065419767,
0.02933316,
0.002094251,
0.0116104735,
0.002933316,
-0.0059382594,
0.0032761046,
0.00022959166,
-0.0063953106,
0.0073196464,
0.01036893,
0.05334542,
-0.008288323,
-0.017026875,
0.0086839795,
0.018623145,
-0.0132272085,
-0.0014965028,
-0.0024404505,
0.030915786,
-0.037955742,
-0.011003345,
-0.00077724346,
0.0013677438,
-0.0047683436,
0.038092177,
-0.0053004334,
-0.03331701,
-0.0070740664,
0.010232497,
0.017176952,
0.012572329,
0.01761354,
-0.008827235,
-0.01446193,
0.009584439,
-0.021269951,
-0.016781295,
0.015389676,
-0.046933055,
0.00020123912,
0.0040657124,
0.022402348,
0.03031548,
0.026440773,
0.011139778,
0.015812619,
0.03266213,
-0.030506486,
0.028841998,
0.012442716,
0.005068497,
-0.0746563,
0.0071763913,
-0.040247824,
-0.02032856,
0.01663122,
-0.018295705,
-0.020301275,
-0.01122846,
-0.0053004334,
0.028978432,
0.003584785,
-0.02933316,
0.0119652,
-0.009127388,
0.003830365,
-0.018077413,
-0.025799537,
0.022511493,
-0.01221078,
0.00307316,
0.021338169,
0.0010650324,
0.02536295,
-0.004843382,
-0.030506486,
-0.004430671,
-0.024530707,
-0.016726723,
-0.006518101,
0.017968265,
0.0022937849,
-0.00030868035,
-0.018568572,
-0.0037382722,
-0.025458453,
0.009086458,
0.0077289464,
-0.007230965,
0.026836429,
0.004676251,
-0.0005930585,
0.010293893,
-0.015607969,
-0.014107203,
-0.011603652,
-0.0028957967,
-0.014980376,
-0.005007102,
-0.0031362604,
0.0101506375,
0.023548387,
-0.018077413,
-0.016412925,
0.017995551,
-0.04199417,
-0.0058905077,
-0.010519007,
0.018295705,
-0.0045466395,
0.045541435,
0.010212032,
0.041230142,
-0.003207888,
-0.009932344,
-0.022170411,
-0.010409861,
0.0034961032,
0.008990955,
0.028623706,
-0.009523044,
-0.018855082,
0.0032300584,
-0.008506616,
0.01122846,
-0.008902272,
0.0017531678,
-0.007735768,
-0.0028565722,
0.010566759,
0.016945016,
0.014571076,
0.005106016,
0.0011110787,
-0.031052219,
-0.009113744,
0.0019168878,
-0.017954621,
-0.029687885,
0.018950585,
-0.002281847,
0.002798588,
-0.009523044,
-0.014107203,
-0.020710574,
0.005242449,
-0.0046591973,
-0.008922738,
-0.0017420826,
-0.004133929,
0.024039546,
0.0035268008,
0.0071354616,
-0.013138526,
-0.0054266346,
-0.02736852,
-0.0024319235,
-0.003826954,
0.005378883,
-0.021324525,
-0.015307816,
0.0050753187,
0.0012756513,
-0.0069512767,
0.004481834,
-0.009959631,
-0.03331701,
0.023507457,
0.02356203,
0.0057915933,
0.020096624,
0.0039156354,
-0.012019773,
0.0012867366,
-0.012681475,
0.001811152,
-0.0038576515,
0.016112773,
-0.004621678,
-0.021092588,
-0.016713079,
-0.0008693359,
-0.011651403,
-0.02237506,
0.007960883,
0.19853774,
0.006941044,
0.015144096,
0.043849662,
0.026126977,
-0.0027525418,
0.022170411,
-0.00024536677,
-0.0012040238,
0.0062622884,
0.008131425,
0.005846167,
-0.007572048,
0.0022886686,
0.011603652,
-0.010873734,
-0.036209397,
-0.014243636,
0.0022136301,
0.005897329,
0.0153487455,
0.0016747187,
-0.039101783,
-0.014543789,
0.020287631,
-0.008704444,
-0.030943071,
0.0068284865,
0.022443278,
0.014448286,
-0.009611726,
-0.013165813,
0.010941951,
0.029469592,
-0.023521101,
0.0078790225,
-0.00021850645,
0.0019271203,
0.0073401113,
-0.00010957299,
-0.012729227,
-0.023862183,
-0.018527642,
-0.030479198,
-0.005430045,
0.009113744,
-0.0033460266,
0.005290201,
-0.019509962,
0.008281501,
-0.026727283,
-0.014953089,
-0.021938475,
0.022811648,
-0.019087018,
-0.0047888085,
0.0018776632,
-0.012176672,
-0.00070902676,
0.026331626,
-0.010130173,
0.0043317573,
-0.019619107,
0.00010781428,
-0.04696034,
0.00046557863,
-0.0009695291,
0.030370051,
0.01466658,
-0.011371715,
-0.0046694297,
0.002298901,
-0.012067525,
0.002597349,
-0.028050685,
-0.02667271,
0.03192539,
0.028787425,
-0.00064976356,
0.027859678,
-0.005020745,
-0.021010729,
-0.0055255485,
0.004403385,
0.0060542277,
-0.024571637,
0.02237506,
-0.0062145367,
-0.027382163,
-0.0140117,
-0.009939166,
-0.012811086,
-0.005412991,
-0.0077289464,
0.0064771706,
0.013261316,
-0.0077016596,
0.023916757,
-0.022729788,
-0.0103143575,
-0.017790902,
0.038747057,
0.0014973554,
0.029224012,
-0.0035268008,
0.0015783627,
-0.04000224,
0.028241692,
0.009256999,
-0.0042805946,
0.003178896,
-0.022593355,
0.0067432155,
-0.02491272,
0.0043454007,
0.011815123,
0.01180148,
-0.017790902,
0.030888498,
-0.0046591973,
0.0017668112,
-0.017354315,
-0.003056106,
0.04281277,
0.01204706,
0.005863221,
-0.0132340295,
0.013827515,
-0.02233413,
-0.008301966,
0.018009195,
-0.010914664,
0.00610539,
0.010839625,
0.00815189,
-0.022361418,
-0.027300302,
-0.022184053,
-0.018718649,
0.0024097532,
0.027464023,
0.0029435484,
0.002360296,
0.015921766,
-0.0156489,
-0.0032965695,
0.014420999,
0.013145348,
-0.0085339025,
-0.0021368866,
-0.0068489513,
-0.008786304,
0.005474386,
-0.0011903805,
0.00027329294,
-0.007851737,
-0.009727694,
-0.016617576,
-0.0046933056,
-0.008574833,
-0.03896535,
0.0015664247,
0.026618136,
-0.007114996,
-0.0034961032,
0.01515774,
-0.17408888,
0.007469723,
-0.003721218,
-0.01065544,
0.01597634,
0.003765559,
0.040466115,
0.008779483,
-0.01262008,
0.00075677846,
0.016126415,
0.016863156,
-0.0156489,
-0.028787425,
-0.004048658,
0.02483086,
-0.013929839,
0.02548574,
-0.000100353085,
0.009945988,
0.011364894,
-0.020792434,
0.008301966,
-0.023166373,
0.0231118,
0.014420999,
-0.0061599636,
-0.0027354877,
-0.015225956,
-0.031788956,
-0.0101506375,
0.014270923,
0.0071900347,
-0.028787425,
-0.0022852577,
0.006838719,
0.01380705,
-0.001568983,
0.004972994,
0.022688856,
0.022716144,
0.017136022,
-0.011815123,
0.0023159552,
0.008711266,
-0.011289855,
0.012920233,
-0.029033005,
0.028569132,
-0.017709041,
-0.0047410573,
0.0025802946,
0.017381603,
0.0037519156,
0.014257279,
-0.00549144,
-0.026699996,
0.0321164,
0.012394965,
-0.028132547,
-0.003946333,
-0.004502299,
0.020355849,
-0.012142563,
-0.021774754,
-0.020464994,
-0.051189773,
-0.00864305,
-0.030588346,
-0.0019185932,
-0.002389288,
0.003490987,
-0.0072582513,
-0.0070536016,
-0.002036267,
0.013936661,
-0.029606026,
0.0044716015,
-0.0064225974,
-0.024203267,
-0.027859678,
0.026154263,
0.020724218,
-0.013309068,
0.0024097532,
0.008465686,
-0.008984133,
0.015676185,
-0.024735358,
0.0071900347,
0.020205772,
-0.015662542,
0.0019731666,
-0.005679036,
0.009932344,
0.022061264,
0.008697622,
-0.0007248019,
0.03552723,
-0.0070467796,
0.014816656,
0.009932344,
0.0040418366,
-0.0010070483,
0.022729788,
0.01086009,
-0.0031175008,
0.00058410503,
0.015389676,
0.0059826,
-0.021488244,
-0.0031703687,
0.01548518,
0.0049798153,
-0.009980096,
0.02614062,
-0.010846447,
-0.034353904,
0.011364894,
-0.013472788,
0.06248645,
-0.004696716,
-0.00749701,
0.016808582,
0.0004201719,
-0.0016252616,
-0.117660075,
-0.008656693,
0.0072173215,
0.02667271,
-0.011003345,
0.0045295856,
-0.003707575,
0.024271483,
-0.028214406,
0.05536463,
0.012190315,
-0.01450286,
-0.016153703,
-0.0030833925,
-0.0030202921,
-0.00083181675,
-0.0066204257,
-0.019318955,
-0.019114304,
0.028841998,
0.016535716,
-0.02233413,
-0.024244197,
0.0041475724,
0.007572048,
0.0017096797,
-0.010955594,
0.010341644,
0.011235282,
0.021010729,
0.010771409,
-0.013916196,
0.002737193,
-0.0013813871,
-0.015635256,
0.008997776,
-0.020437708,
-0.032552984,
0.016371995,
-0.012203959,
-0.0054505104,
-0.020014765,
0.013943483,
-0.0047956305,
0.03135237,
-0.0064498843,
0.0013651857,
0.0060167084,
-0.014025343,
-0.0041202856,
-0.0098231975,
-0.016071843,
-0.034490336,
-0.011433111,
-0.014475573,
0.012858838,
0.012224424,
0.0016960364,
0.013343177,
0.01659029,
-0.017477104,
0.013916196,
-0.018896012,
0.023261877,
0.0028019988,
-0.0014785959,
-0.017490748,
-0.018131984,
0.02835084,
0.0052595036,
-0.0075993347,
0.016849512,
-0.027723245,
-0.008145068,
-0.009284286,
0.001206582,
-0.022593355,
-0.0112830335,
-0.01102381,
-0.012599615,
-0.0027491308,
-0.0025461863,
-0.030779352,
-0.008301966,
0.013759298,
0.012053882,
0.0011869697,
-0.0060678707,
0.0017173542,
-0.034381192,
-0.0030680439,
0.010348465,
0.00051844656,
-0.0153487455,
-0.01245636,
-0.007981348,
-0.027996112,
-0.01221078,
0.013916196,
-0.013295425,
-0.037792023,
-0.00692399,
-0.060740102,
0.020464994,
0.015812619,
-0.027927896,
0.00757887,
-0.003519979,
0.013459145,
-0.013493253,
0.010075599,
0.0034961032,
-0.030233618,
0.0027678905,
-0.03495421,
-0.018814152,
-0.025253803,
-0.0069751525,
0.022224983,
0.0107986955,
0.043549508,
0.034899637,
-0.012872482,
-0.0064260084,
0.02204762,
0.023507457,
0.011248926,
-0.008383826,
-0.005003691,
0.034517623,
-0.021542817,
0.0030475787,
0.002906029,
-0.013002093,
-0.012545042,
-0.005194698,
-0.011173887,
-0.0046694297,
-0.01695866,
0.017572608,
0.007606156,
-0.0014743323,
-0.036045678,
-0.019878332,
-0.0073469332,
0.0038951705,
-0.025144657,
0.016371995,
-0.00075208856,
-0.0142027065,
0.004294238,
0.0055835326,
0.048051808,
0.004420439,
0.009584439,
-0.03315329,
-0.0040077283,
-0.010594046,
0.006599961,
-0.008704444,
0.023589317,
-0.0062998077,
0.031761672,
0.014803013,
0.0145301465,
0.015798977,
-0.006999028,
-0.0119379135,
-0.0140117,
0.019237095,
0.013022558,
-0.0035643198,
-0.022443278,
0.029469592,
0.0048331497,
0.009427541,
0.029769745,
-0.017122379,
-0.000528679,
0.014762083,
-0.0062622884,
0.023957686,
0.02933316,
0.009645834,
-0.01765447,
0.035499945,
0.029687885,
0.001922004,
0.009059171,
0.010143816,
-0.0066204257,
0.013772941,
-0.0000491906,
0.014980376,
-0.032334693,
0.015717115,
-0.0052560926,
0.03348073,
-0.019005159,
0.0009303045,
0.024885433,
0.021447314,
-0.020246701,
0.0018947175,
-0.009536687,
-0.004403385,
-0.018595858,
0.013616043,
-0.021215377,
-0.031161364,
0.014216349,
-0.005068497,
0.040275108,
-0.0148303,
-0.0012116982,
0.00020624878,
0.0022750252,
0.021051658,
-0.0027559525,
-0.008813591,
-0.0077016596,
-0.012340392,
0.029606026,
0.008308788,
0.022593355,
0.00782445,
0.023821253,
0.034681343,
0.00831561,
-0.022634285,
0.029906178,
0.0062145367,
-0.010109708,
0.004642143,
-0.011590009,
-0.0055664787,
0.0059723677,
0.0022869632,
0.004294238,
0.0049764044,
-0.021242665,
0.08196913,
0.031024931,
0.019414458,
-0.010089242,
-0.025390236,
0.012797443,
0.0140526295,
-0.0034466463,
0.0051537678,
-0.026577206,
0.0024643263,
-0.0065283333,
0.0068864706,
-0.032880425,
0.012285818,
0.009905057,
-0.024694426,
0.006674999,
-0.0478608,
-0.015444249,
0.025049154,
-0.005754074,
0.030451912,
0.0052185734,
-0.018554928,
-0.012599615,
0.021092588,
0.011453575,
0.007606156,
-0.03749187,
0.019851044,
0.002012391,
-0.016003625,
-0.009400254,
0.002114716,
-0.005372061,
-0.016440213,
-0.016167346,
0.022716144,
0.020601427,
-0.0023091335,
-0.01971461,
-0.0062554665,
-0.008158711,
-0.002471148,
-0.00083906477,
-0.007708481,
0.00016840985,
-0.01934624
] |
Dietary restriction (DR) increases healthspan and longevity in many species, including primates, but it is often accompanied by impaired reproductive function. Whether signals associated with the reproductive system contribute to or are required for DR effects on lifespan has not been established. Here we show that expression of the cytochrome P450 DAF-9/CYP450 and production of the steroid hormone Δ(7)-dafachronic acid (DA) are increased in C. elegans subjected to DR. DA signalling through the non-canonical nuclear hormone receptor NHR-8/NHR and the nutrient-responsive kinase let-363/mTOR is essential for | [
-0.010172046,
-0.0231796,
-0.004384028,
-0.03876114,
-0.0055333725,
0.02231243,
-0.014081195,
0.014700602,
-0.026785929,
-0.019449392,
0.00012194583,
0.015898123,
-0.0018633839,
0.011534742,
-0.029456262,
0.008038531,
0.043716397,
-0.02583617,
0.011176862,
0.015554008,
-0.013902254,
0.011644859,
0.008499646,
-0.016421178,
0.014205076,
0.0007493109,
0.011520977,
-0.031410836,
-0.008843761,
-0.009724696,
0.020385385,
0.0021696463,
0.007487947,
-0.009339287,
0.013282848,
-0.004796966,
0.0013119392,
0.0012508588,
0.008141766,
-0.015526478,
-0.0057949,
0.004163794,
-0.0021094263,
0.0021421171,
-0.01090157,
0.011624212,
0.0148520125,
-0.019297982,
-0.0016078784,
0.010061929,
0.026840987,
0.0083138235,
-0.02356501,
-0.0015003424,
-0.01272538,
0.00030841326,
0.009869224,
0.026896045,
0.01275291,
-0.0062663383,
-0.013702668,
0.014328958,
-0.027033692,
0.019573273,
-0.021789376,
0.0015416362,
0.019697156,
0.017563641,
0.017302113,
0.01460425,
0.044845097,
0.012629028,
0.00093083165,
0.002192014,
0.012401912,
-0.005268404,
-0.0090502305,
0.012629028,
0.018127989,
0.0047797603,
0.04289052,
-0.016820353,
0.0045870556,
0.016765293,
0.025134176,
-0.017453523,
-0.014370251,
0.012615263,
0.017604934,
-0.021183733,
0.0009790078,
-0.013682021,
0.012608382,
0.033640705,
-0.00698898,
-0.005922223,
0.015388832,
0.017494818,
-0.0143427225,
-0.024322063,
-0.022780428,
0.016971763,
-0.002455262,
-0.017715052,
-0.0018719868,
0.0021541612,
-0.016324826,
-0.0029008912,
0.013227789,
-0.033448,
-0.014163782,
0.04082583,
0.002634202,
-0.04545074,
0.020853382,
-0.014384016,
0.023041954,
-0.000158293,
-0.013076378,
-0.008836878,
0.024748767,
0.013000673,
0.027336514,
-0.0009196479,
0.009621462,
0.035099752,
0.009958695,
0.0038644138,
-0.015030952,
-0.0013248436,
0.0074260063,
-0.0041328236,
0.024198182,
0.019710919,
-0.031768717,
0.021665495,
-0.032842357,
-0.011438389,
-0.0024587032,
-0.025189234,
-0.0013257039,
0.02481759,
-0.034962106,
-0.004975906,
-0.013881608,
0.029373676,
0.018320695,
0.003392976,
0.00504817,
0.009002054,
-0.0018754279,
-0.006514101,
0.027584275,
-0.011293861,
0.013874725,
0.040550537,
0.014232606,
0.012161031,
-0.004903642,
-0.018733632,
0.016228473,
-0.014989659,
-0.0011562271,
-0.00079189515,
0.009284228,
0.026304167,
0.009249817,
0.0068857456,
0.0046662022,
-0.0025997905,
-0.0045147915,
0.017040586,
-0.02001374,
0.038072906,
-0.009291111,
0.01514107,
-0.025849935,
-0.0011897783,
0.00032518888,
-0.026785929,
-0.00842394,
-0.0009781475,
0.038816195,
0.024322063,
-0.011562271,
0.009098406,
0.0033843732,
-0.0052752863,
-0.009428757,
-0.011830681,
-0.0060013696,
0.014989659,
-0.017866462,
-0.022711605,
-0.6311899,
-0.013344788,
-0.0016896058,
-0.0038300024,
0.014769425,
0.027708158,
0.016655177,
0.019050218,
-0.0037508558,
0.018761162,
0.0012543,
0.0040433537,
0.009146582,
-0.029346146,
-0.006393661,
-0.009648991,
0.0020165152,
-0.015843065,
0.024969,
0.015925651,
-0.03306259,
-0.005701989,
-0.0066999234,
0.0059600757,
0.0017446642,
0.018582221,
0.020853382,
-0.00082587654,
0.014700602,
0.023688892,
-0.02269784,
0.03375082,
0.01565036,
-0.0043599396,
0.051149286,
-0.004745349,
0.014191312,
0.025946287,
0.012236737,
0.04924977,
-0.03262212,
0.013668257,
0.03309012,
0.012429441,
-0.040523008,
0.0020681324,
0.004924289,
0.02001374,
0.014686838,
-0.011844446,
0.006445278,
0.027900862,
-0.012291796,
0.007894003,
0.014218841,
0.000035567533,
0.019642096,
-0.052250456,
0.0182794,
0.016022004,
0.001935648,
0.031851303,
-0.000839211,
-0.003437711,
-0.005736401,
0.021376437,
-0.014714367,
0.0024225712,
-0.01152786,
-0.020853382,
0.013792138,
0.025285587,
-0.0032174774,
-0.0025223645,
0.02257396,
0.013475552,
0.030722607,
0.016627647,
-0.01950445,
0.043881573,
0.0153475385,
-0.0005170331,
-0.02233996,
0.018141754,
0.030584961,
-0.03201648,
-0.008141766,
0.013069496,
-0.017811403,
-0.0059669577,
0.024294535,
0.0042567053,
-0.015030952,
-0.029428734,
-0.02004127,
0.0057742535,
-0.012470735,
-0.008203707,
-0.00719889,
-0.019876095,
-0.010240869,
0.010220222,
-0.015567772,
0.0007398477,
0.012174796,
0.002081897,
-0.03446658,
0.016999291,
0.052140336,
-0.013854079,
0.0024088065,
0.011355802,
-0.020660678,
-0.0021644847,
-0.0029473468,
-0.017481053,
0.028685445,
-0.0012689249,
0.011211274,
-0.031878833,
0.019628331,
-0.0031383308,
0.019187864,
-0.022587722,
0.012690969,
0.016324826,
-0.0098141655,
-0.0060185753,
-0.0031331691,
0.0045560854,
0.015361303,
0.0072470666,
0.008761173,
-0.011293861,
0.033943526,
0.0066827177,
0.01547142,
-0.003214036,
0.015622831,
-0.028768033,
-0.025423232,
-0.006077075,
-0.012044032,
-0.0005303676,
-0.012360618,
-0.003372329,
-0.0045560854,
0.0023004103,
0.010399162,
-0.008788703,
-0.008795585,
-0.003706121,
-0.015044717,
0.038458318,
-0.019600803,
-0.016256003,
-0.0031331691,
-0.013874725,
-0.016834116,
-0.008362,
0.015416361,
0.011720564,
-0.03336541,
-0.012869909,
-0.024294535,
0.0022746015,
0.017756345,
0.026207814,
-0.0003073379,
-0.020247739,
-0.0037233266,
-0.0003249738,
-0.0016242238,
0.0066758352,
-0.014521662,
0.0019941477,
-0.005402609,
0.0056916657,
-0.014865777,
-0.0021799698,
0.0036235333,
-0.018540928,
-0.020770794,
-0.015788006,
0.02989673,
-0.0046214676,
0.020633148,
0.017302113,
-0.00922917,
0.03878867,
-0.009380581,
0.018444575,
-0.016806588,
0.00889882,
0.004181,
-0.039531957,
0.0057570473,
0.0102959275,
0.0012121459,
0.005154846,
0.026827222,
-0.051259402,
0.019201629,
-0.04363381,
0.0095457565,
0.010523044,
0.017247055,
-0.0093048755,
-0.0050619347,
0.012147267,
-0.006871981,
0.016256003,
-0.0026651723,
0.008829996,
-0.010185811,
0.012463853,
-0.019132806,
-0.0024810708,
-0.013723315,
-0.010529926,
-0.002666893,
-0.028988266,
0.030172022,
-0.010777689,
-0.011913269,
0.019573273,
-0.007921533,
0.03485199,
-0.001227631,
-0.013592551,
-0.0123055605,
-0.0033413589,
-0.012670322,
0.0065932474,
0.0098004015,
0.011541625,
-0.0008598579,
-0.019559508,
0.03154848,
0.00800412,
0.01600824,
-0.0006946826,
0.032209184,
0.00788712,
-0.006169986,
-0.006971774,
0.016517531,
0.029318616,
-0.030474843,
0.009201641,
-0.0004417579,
0.026896045,
-0.011176862,
-0.00791465,
0.010116987,
0.012174796,
0.012966261,
-0.006641424,
0.012167914,
0.02479006,
0.028410152,
0.017880227,
0.009614579,
-0.019697156,
0.014108724,
0.0023313805,
0.011548507,
-0.0070887734,
0.022973131,
-0.01631106,
-0.014452839,
-0.006875422,
0.0059669577,
-0.038871255,
0.00056047767,
0.0070440383,
0.010330339,
0.013633844,
0.02022021,
0.010612513,
0.012002739,
-0.01424637,
0.043661337,
0.027859569,
-0.011775623,
-0.04605638,
-0.020812089,
0.0031555365,
-0.0066620708,
0.008472117,
0.008162413,
-0.008245001,
0.019573273,
0.018265635,
-0.0028664798,
-0.017068114,
0.019174099,
-0.020591855,
0.011369566,
-0.008320706,
0.013654492,
0.030832723,
0.00057123124,
-0.0036545035,
0.020908441,
-0.016957998,
-0.018320695,
-0.038485847,
0.008651056,
-0.0055299317,
0.00046928713,
-0.00074199843,
-0.014122489,
-0.021637965,
0.020564325,
-0.0061390153,
-0.021486554,
-0.0010796615,
0.0062078387,
0.0006138155,
-0.013117672,
-0.016751528,
-0.008389529,
-0.021555377,
0.032842357,
0.024831355,
0.007370948,
0.010254634,
-0.0048761126,
0.0011854769,
-0.003867855,
-0.021169968,
0.030006846,
0.0034927696,
-0.004057118,
-0.013654492,
0.0019786626,
-0.01167927,
0.010605631,
0.005337227,
-0.005788018,
-0.028038507,
-0.025368175,
-0.00020367319,
0.0010822424,
-0.012209208,
0.0323193,
0.042615227,
0.03559528,
-0.0013497919,
0.013792138,
0.020082563,
0.020096328,
-0.008940114,
0.0009867504,
0.016324826,
-0.010240869,
0.028933207,
-0.0040295892,
-0.011121804,
0.018127989,
0.0024587032,
0.0029611115,
0.004456292,
0.018210577,
0.010977276,
0.014218841,
0.0017395024,
0.01532001,
-0.007013068,
-0.024294535,
0.016063299,
-0.013227789,
-0.014260135,
0.034053642,
-0.015030952,
-0.019146571,
-0.022959366,
0.008121119,
-0.006610453,
0.0132622,
-0.017302113,
-0.015856829,
-0.021927021,
-0.0067997165,
-0.009745343,
0.029621437,
0.009112171,
0.006156221,
0.012491383,
-0.015884358,
-0.016297296,
-0.009662755,
-0.0009153465,
-0.016503766,
-0.027198866,
0.004972465,
0.016407413,
-0.0024776296,
0.012918085,
0.019311747,
-0.019394334,
-0.0027993773,
-0.0028441122,
-0.021321379,
-0.0074741826,
-0.024390886,
-0.026441813,
0.005068817,
-0.008382646,
0.008293177,
-0.045918733,
-0.032814827,
0.003279418,
-0.0025034382,
-0.0015330333,
0.011094275,
-0.0034652401,
-0.02377148,
0.0006237088,
0.033310354,
0.026152756,
0.014590485,
-0.0040158248,
0.00788712,
-0.009291111,
-0.030722607,
-0.0076255933,
0.010467985,
-0.023454893,
0.014741896,
0.0069476864,
-0.010894688,
-0.011156215,
0.03168613,
-0.009531992,
-0.0048726713,
0.0053475504,
0.033007532,
0.008967643,
0.011637976,
0.00889882,
-0.003007567,
-0.0026118346,
-0.007081891,
-0.0062284856,
0.033640705,
0.024473473,
-0.013943548,
0.024115594,
-0.012222973,
-0.0009196479,
-0.020371621,
0.016324826,
0.009938047,
0.025602171,
-0.017728817,
-0.0450378,
-0.026964867,
0.009187876,
-0.031163074,
0.0024810708,
-0.005457667,
-0.019284217,
-0.018953865,
-0.013936666,
0.0060529867,
-0.021995844,
0.021403966,
-0.034604225,
-0.013386082,
-0.009463169,
0.00093771395,
-0.011479683,
-0.0058430764,
-0.011913269,
-0.023468658,
-0.00057295186,
-0.016710235,
-0.035457633,
0.024019241,
-0.014370251,
0.026689576,
0.037357148,
0.025643466,
-0.012388147,
0.023730185,
0.02323466,
0.01021334,
-0.0056606955,
0.00050283835,
0.024611121,
-0.020412914,
0.008066061,
0.02849274,
-0.0040605594,
-0.0022436313,
-0.005818988,
0.018940102,
0.011218156,
-0.022973131,
-0.019366805,
-0.00027701276,
-0.057536066,
-0.012794204,
0.0098141655,
-0.012016503,
-0.0024845118,
-0.011176862,
-0.011706799,
0.033915997,
0.012443206,
-0.002487953,
-0.017302113,
0.018898807,
-0.028038507,
0.041927,
0.0060185753,
0.0120646795,
-0.02019268,
-0.015884358,
0.008678585,
0.003084993,
-0.0017222967,
-0.014631779,
0.025051588,
0.031465895,
-0.01938057,
0.017191997,
-0.014191312,
0.0011493448,
-0.027818274,
-0.014039901,
-0.018169284,
-0.017370936,
-0.013750844,
-0.02918097,
-0.032236714,
-0.00018453179,
-0.00013226928,
-0.026469342,
0.037081856,
0.003933237,
-0.020467972,
0.00860288,
-0.0110736275,
0.018045401,
-0.025960052,
0.022216078,
0.017191997,
0.008100472,
-0.009704049,
-0.020137623,
0.015870593,
-0.007322772,
0.027074985,
0.034631755,
-0.006940804,
-0.022629017,
-0.007666887,
0.008176178,
-0.030722607,
-0.0443771,
0.014328958,
-0.01299379,
0.031163074,
0.0015614228,
0.01633859,
-0.022491371,
-0.00976599,
-0.018898807,
-0.0033602852,
0.015443891,
-0.01777011,
0.013640727,
0.000015713698,
-0.01442531,
0.02165173,
-0.01215415,
-0.0076049464,
-0.022216078,
-0.025822407,
0.0018771485,
-0.007618711,
-0.012236737,
0.03127319,
0.01547142,
0.0027735687,
-0.0014091518,
0.013152083,
0.01128698,
-0.01373708,
-0.01631106,
0.039119016,
-0.0027580834,
-0.018788692,
0.035072222,
0.0059187817,
0.0019631772,
-0.0049690236,
-0.016379884,
0.0007411381,
-0.036311038,
-0.018155519,
0.0034170642,
0.012863027,
-0.026827222,
-0.00427047,
-0.026772164,
0.007666887,
-0.015402597,
-0.025120411,
0.027130043,
-0.019297982,
0.0018754279,
0.015498949,
-0.00047961058,
0.037797615,
-0.0085684685,
-0.01532001,
-0.0016422899,
0.023509951,
-0.022023374,
0.030750135,
0.0043599396,
-0.008265647,
-0.011576036,
0.021734318,
-0.024927706,
-0.019490685,
0.0080591785,
-0.014659308,
-0.04465239,
-0.005726077,
0.01532001,
0.016806588,
0.024501003,
0.0118375635,
0.032154124,
-0.0100344,
0.0095870495,
-0.017453523,
-0.021954551,
0.017219525,
-0.008148648,
0.023496186,
0.006490013,
-0.015278716,
-0.00078028126,
-0.018871278,
0.004614585,
0.0071575963,
-0.0050791404,
-0.0022556752,
-0.020922204,
0.011390214,
-0.014700602,
-0.012161031,
-0.018761162,
-0.008678585,
-0.037384678,
0.033503056,
-0.015664125,
-0.006968333,
-0.0018203695,
-0.0038368846,
0.015498949,
0.0062284856,
-0.0024655855,
-0.0016594956,
0.012037151,
-0.005994487,
-0.02428077,
-0.006871981,
-0.019339275,
0.025037823,
0.027308984,
-0.0131107895,
-0.020523032,
-0.0055781077,
-0.02918097,
-0.013723315,
0.004249823,
0.015994476,
-0.0008981407,
0.011548507,
0.009015819,
0.0057123126,
0.009380581,
0.011892621,
-0.00400206,
-0.027501687,
0.0046662022,
-0.008203707,
0.036751505,
0.014452839,
-0.02693734,
-0.0041431473,
0.030447314,
-0.030364726,
-0.011121804,
0.007598064,
-0.008699233,
0.019876095,
-0.014094959,
-0.0037026796,
0.012690969,
-0.0015510994,
-0.005457667,
-0.0017386421,
-0.011197509,
0.00636269,
-0.016104592,
-0.019848567,
-0.011066745,
-0.0243083,
0.00089469954,
-0.013186495,
-0.020165151,
-0.022560194,
0.010736395,
-0.02233996,
0.0012654837,
0.025492055,
0.0063007497,
0.0138609605,
0.020880911,
-0.029676497,
-0.029291088,
-0.020591855,
-0.018499633,
-0.008678585,
0.0048313774,
-0.00054155133,
-0.0026944221,
-0.003891943,
0.014232606,
-0.022092197,
0.0143564865,
-0.025381938,
-0.017577406,
-0.022711605,
0.030557431,
-0.0036510625,
0.0015846506,
-0.013227789,
0.0045251152,
-0.013317259,
-0.006703364,
-0.0023451452,
-0.005991046,
-0.010447338,
-0.006830687,
0.012869909,
-0.03311765,
0.0105643375,
-0.011486566,
-0.014287664,
-0.019573273,
0.012746028,
0.19567768,
-0.0014108724,
0.004573291,
0.015498949,
0.027019927,
0.007508594,
0.021046087,
-0.008781821,
-0.0100344,
-0.005430138,
0.0015003424,
0.019160336,
-0.020481737,
0.003348241,
0.021307614,
-0.022739133,
-0.019848567,
0.0024328947,
-0.014549191,
-0.0073571834,
0.006806599,
-0.02282172,
-0.010523044,
-0.0138471965,
0.020867147,
0.002204058,
-0.03234683,
-0.014714367,
0.00773571,
0.002625599,
-0.014452839,
-0.019972447,
0.0070887734,
0.008678585,
0.027556747,
-0.0029232588,
-0.019394334,
-0.0018960749,
0.0060805157,
-0.023977948,
0.011899504,
0.003754297,
0.0028871268,
0.0057742535,
0.012635911,
0.008664821,
0.007343419,
-0.031218132,
-0.026992397,
0.023262188,
-0.056352306,
0.0046937317,
0.031713657,
0.04399169,
0.0061596623,
-0.017164467,
0.0052821687,
0.003571916,
-0.02335854,
0.020715736,
-0.03262212,
0.01633859,
-0.012924967,
0.009470051,
-0.019587038,
0.028244978,
-0.03449411,
0.028960736,
0.010832747,
-0.008169295,
-0.017274585,
-0.037247032,
-0.01621471,
-0.003392976,
-0.0077494746,
-0.027859569,
0.012567088,
0.008465234,
0.03234683,
0.013379199,
0.00034390014,
-0.026207814,
-0.023509951,
0.009194759,
-0.014920835,
-0.0285478,
0.022766663,
0.0053475504,
-0.031218132,
-0.0058912523,
0.02004127,
-0.016600117,
-0.029951788,
-0.014136253,
0.0056813424,
-0.012401912,
0.004810731,
0.009291111,
0.0066861585,
-0.014136253,
-0.040467948,
0.08671703,
0.0028234653,
0.016462471,
-0.026469342,
0.0077219456,
-0.011500331,
0.036008216,
0.00098589,
-0.015554008,
0.009057112,
-0.016792823,
0.008967643,
-0.012649675,
0.006376455,
0.013750844,
0.00038175282,
-0.0225189,
0.037522323,
-0.010598749,
-0.007900885,
-0.023799008,
-0.013537493,
0.031906363,
-0.029483791,
-0.0140743125,
-0.025904993,
-0.031218132,
-0.016999291,
-0.032869887,
0.0020440444,
-0.019297982,
-0.022023374,
0.008079825,
0.011548507,
-0.0021662053,
0.011204392,
-0.029428734,
-0.0013558139,
0.013778374,
-0.000087373,
-0.0028595973,
0.016132122,
0.001505504,
0.013867843,
-0.012938732,
0.001621643,
0.0123330895,
0.0031916685,
0.011610447,
-0.0093048755,
-0.0055953134,
0.0031641393,
-0.0102959275,
0.0038575316,
-0.016297296,
-0.025340645,
-0.020867147,
-0.0125602055,
0.01353061,
-0.02882309,
0.006042663,
0.00755677,
-0.009463169,
0.0009893313,
0.013000673,
-0.17607687,
0.021156203,
0.02852027,
-0.03061249,
0.028933207,
0.007666887,
0.015581537,
-0.0015450773,
0.0017231569,
0.017687522,
0.008836878,
0.008430823,
-0.039504427,
-0.038926315,
0.014452839,
0.0018358547,
-0.0073778303,
0.024349593,
0.004242941,
-0.0041741175,
0.029759083,
-0.026634518,
0.008623527,
-0.010605631,
-0.015567772,
0.0030781105,
0.015884358,
-0.02165173,
-0.0019993095,
-0.007838945,
-0.017673757,
0.023468658,
0.0316586,
-0.00788712,
0.013640727,
-0.0039022665,
-0.020798324,
-0.013544375,
-0.011266332,
0.020289034,
0.01833446,
0.03091531,
0.0028888471,
-0.013248436,
-0.028630385,
0.02320713,
-0.00976599,
0.005402609,
0.0037680615,
-0.012353736,
0.016228473,
-0.016228473,
-0.0020750146,
0.017068114,
0.007894003,
-0.0014495853,
0.011094275,
0.0298692,
-0.010550573,
-0.013214025,
-0.00343427,
-0.0025154823,
0.032897413,
0.0100344,
0.037384678,
-0.01615965,
-0.03793526,
-0.0030591842,
-0.019036453,
0.01567789,
-0.028465211,
-0.009366816,
0.00170251,
-0.015953181,
0.030997898,
0.016944233,
-0.009834813,
-0.0061665447,
0.0036269743,
-0.015168599,
-0.0030695077,
0.005877488,
-0.02545076,
-0.024473473,
-0.018141754,
-0.013571904,
0.025822407,
0.020165151,
0.005244316,
0.0024002036,
0.028093567,
-0.024858883,
0.01932551,
-0.016724,
-0.00510667,
0.011273215,
-0.0071713612,
-0.009043348,
0.003599445,
-0.0035753571,
0.016627647,
-0.018926337,
-0.015664125,
-0.007880239,
0.021417731,
-0.007192008,
-0.03801785,
0.017095644,
0.040578067,
-0.010357868,
0.0025464527,
0.018293165,
-0.00800412,
0.025643466,
0.002338263,
0.035264928,
0.00020474855,
-0.008306941,
0.003984854,
-0.02514794,
0.06480378,
0.017728817,
-0.011734329,
0.010646924,
-0.006871981,
-0.01577424,
-0.12410171,
-0.025120411,
0.0019201629,
0.025698524,
-0.017343407,
0.0120784445,
0.010516161,
0.010440456,
-0.02798345,
0.0118100345,
0.0040330305,
-0.0064315135,
-0.0077494746,
-0.011768741,
0.020908441,
-0.019573273,
0.015086011,
-0.011163098,
-0.0012413956,
0.04110112,
0.009752225,
-0.012401912,
0.0065691597,
0.0008972804,
-0.009724696,
0.002825186,
-0.0014082915,
0.0020233975,
0.0049655824,
0.008885055,
-0.011672388,
-0.006889187,
0.014163782,
0.0047143786,
-0.03765997,
-0.03936678,
0.00719889,
-0.017715052,
0.033888467,
-0.015209893,
0.0051961397,
0.0057742535,
0.014631779,
0.0047522313,
0.005013759,
-0.004470057,
0.012209208,
0.025904993,
0.013241554,
-0.0044734976,
-0.04644179,
-0.010385397,
-0.03587057,
0.0031796247,
0.030474843,
-0.044762507,
0.024046771,
0.020591855,
0.010309692,
-0.00006393016,
-0.004119059,
0.017288348,
-0.028038507,
0.002950788,
0.007302125,
-0.011906386,
-0.0358981,
-0.013757726,
0.009566403,
-0.023000661,
0.003984854,
0.0050756996,
-0.003482446,
-0.0046214676,
-0.020082563,
0.013344788,
-0.017687522,
-0.020646913,
-0.008981407,
-0.02795592,
-0.004435645,
-0.011576036,
0.0222849,
-0.030089434,
0.008217472,
0.014439074,
0.018651044,
-0.007618711,
0.017549876,
-0.0015467979,
-0.017659992,
0.031713657,
-0.0098279305,
-0.016283533,
-0.01833446,
-0.0030609048,
0.017425995,
-0.0011295582,
0.03022708,
-0.0022109402,
-0.04291805,
-0.014232606,
-0.050020587,
0.0133241415,
-0.0008981407,
-0.008637292,
0.0024260122,
-0.025436997,
0.01266344,
0.011940798,
-0.003377491,
0.024156889,
-0.02320713,
-0.0006783371,
-0.015430126,
-0.013537493,
-0.022945603,
-0.032952473,
0.034686815,
-0.011004805,
0.030805195,
0.028740503,
0.0123055605,
0.022147255,
0.009552638,
-0.013055732,
-0.032897413,
-0.01021334,
-0.00052649627,
0.0031589777,
0.0044631744,
0.015099776,
0.016407413,
-0.04250511,
-0.002374395,
-0.0011046098,
-0.028066037,
-0.011039216,
-0.028437681,
0.03209907,
0.017425995,
0.02535441,
-0.011844446,
-0.022835486,
-0.0035787981,
-0.017866462,
0.0016431501,
0.0014349604,
-0.051314462,
0.007212655,
0.0063902196,
-0.0006740357,
-0.00021937345,
0.0077907685,
-0.0024707473,
-0.0055987546,
0.008114236,
0.00037164442,
-0.009669637,
-0.0017179953,
-0.008761173,
-0.021734318,
0.0047419076,
0.0030127286,
0.02019268,
-0.011486566,
0.0292085,
-0.035705395,
-0.020977264,
-0.00474879,
-0.0033275941,
-0.014645544,
-0.039917365,
-0.0027942155,
0.02333101,
0.012477618,
0.011293861,
0.0010203016,
-0.03163107,
-0.005240875,
-0.026276639,
0.007859591,
0.010509279,
0.002147279,
-0.015966946,
0.013186495,
-0.008279412,
0.020798324,
0.0026152756,
-0.009917401,
0.024624884,
-0.004184441,
0.0066379826,
0.01580177,
0.03449411,
0.017370936,
-0.0055127256,
0.008403294,
-0.0035787981,
-0.011631094,
-0.004769437,
0.015058482,
0.008623527,
0.011293861,
0.00024303138,
-0.018320695,
-0.00636269,
0.023661362,
0.00036540735,
-0.04534062,
-0.006496895,
0.022477606,
0.00788712,
0.0054439027,
0.0058740466,
0.002914656,
0.0063420436,
0.030529901,
-0.00091104506,
-0.009745343,
0.0064315135,
-0.006627659,
0.013227789,
0.024556061,
-0.011913269,
0.011066745,
0.022064667,
0.008891937,
0.035953157,
-0.019435627,
0.015209893,
-0.0060392222,
0.026441813,
0.0013480714,
-0.015278716,
-0.0061940737,
-0.0013489317,
-0.024211947,
0.006964892,
0.025175469,
-0.03209907,
0.08456975,
0.024074301,
-0.018293165,
0.0118100345,
0.0019115601,
0.02494147,
-0.007955944,
0.016820353,
-0.019573273,
-0.011300744,
0.015856829,
-0.041046064,
0.025395703,
-0.01726082,
0.0030557432,
0.015058482,
-0.009917401,
0.014796955,
0.00134377,
-0.04355122,
0.014060548,
0.0061596623,
-0.0070474795,
0.0085684685,
-0.030337198,
-0.008258766,
0.038595963,
-0.0018651044,
0.021899492,
-0.02231243,
-0.0024982765,
0.013275965,
-0.018802455,
0.005203022,
-0.0032484476,
0.0036338568,
-0.009552638,
0.011913269,
0.015870593,
-0.0017102526,
-0.016999291,
0.0067205704,
-0.013454905,
-0.0066827177,
0.017522346,
-0.007838945,
0.0028234653,
-0.008430823,
-0.012050915
] |
Galanin (GAL) is known to stimulate feeding behavior. This peptide has different properties and functions from other feeding stimulants, e.g., neuropeptide Y and agouti-related protein. Hypothalamic GAL is relatively unresponsive to food deprivation and to changes in corticosterone, glucose utilization, dietary carbohydrate and leptin. This indicates that this peptide is not essential under conditions when food is scarce or low-energy, high-carbohydrate diets are being consumed. In contrast, recent evidence suggests that GAL in the paraventricular nucleus (PVN) functions in close relation to dietary fat and alcohol. In | [
-0.037664045,
0.005038909,
0.016853154,
-0.0071291723,
-0.0047211107,
-0.023313966,
-0.011283487,
-0.019919746,
-0.024427898,
-0.020483265,
0.01632895,
0.00018449518,
-0.009992636,
-0.010254738,
-0.009907452,
0.012947835,
0.04382344,
0.0044655614,
-0.0025620463,
0.0009050707,
-0.004780084,
0.03158328,
0.015215016,
-0.019316912,
0.012941282,
0.0093373805,
-0.0057302034,
-0.04555331,
0.007771322,
0.009815717,
0.013308225,
-0.008852492,
-0.010444761,
0.019579014,
0.002797938,
-0.0072405655,
0.012777468,
-0.016473105,
-0.00086493633,
0.0026013616,
0.012246712,
0.014232134,
-0.004766979,
0.0023130495,
-0.0025030733,
-0.0044229697,
0.010333368,
-0.018216083,
0.007030884,
0.016892469,
0.022462133,
0.016302738,
-0.013072333,
-0.010916545,
-0.013144411,
-0.0048849243,
0.004134658,
-0.010556155,
0.024860367,
-0.049144108,
-0.010457867,
0.0025292835,
-0.004291919,
0.029565096,
0.025554936,
0.013282015,
-0.013996243,
0.018661657,
-0.0126333125,
0.0028782068,
0.019500382,
0.018897548,
-0.0146646025,
0.005366537,
0.03803099,
-0.012548129,
-0.010877229,
0.0059759235,
-0.003241873,
-0.00089032744,
0.036484588,
-0.040678218,
-0.016315844,
0.043613758,
0.004806294,
-0.0053141164,
0.006011963,
0.009782954,
0.00094192877,
-0.006526338,
-0.007489562,
0.005415681,
0.024244428,
0.030613504,
-0.010713416,
0.011178647,
0.010274395,
0.027101338,
0.026944077,
0.008944228,
-0.013983137,
0.032028854,
-0.003538376,
-0.02512247,
0.009756744,
0.0025735132,
-0.010018846,
-0.017442882,
0.026629554,
0.005274801,
-0.013445828,
0.031766754,
-0.004327958,
-0.042014938,
-0.024414793,
0.011126227,
0.026524713,
0.009710876,
-0.00282251,
-0.012476051,
0.020077007,
0.0075157722,
0.021453042,
0.026655765,
0.004016712,
0.014074873,
0.009573272,
-0.03027277,
-0.023615383,
-0.021138519,
-0.003961015,
0.002978133,
0.011853559,
0.029355414,
-0.026039826,
0.013943822,
0.00056556676,
-0.015477118,
-0.018071927,
-0.006568929,
0.0016889193,
0.016040638,
-0.021819985,
0.012233607,
0.00034789933,
0.028673949,
0.013314777,
0.017495302,
-0.0058153863,
0.016145479,
0.012056688,
-0.008053081,
0.003384391,
-0.003048573,
0.008492102,
0.0134327235,
-0.00083012594,
0.03457124,
0.005713822,
-0.01329512,
-0.0050159753,
-0.014140398,
-0.012875756,
-0.014481131,
0.01267918,
0.03669427,
0.015319857,
0.004766979,
-0.0045867837,
0.0068015447,
0.007954793,
0.004537639,
-0.012233607,
0.022462133,
-0.035305128,
0.030194141,
-0.002965028,
0.0050683958,
0.015450908,
-0.0022311425,
-0.02607914,
-0.008361051,
0.004481943,
0.0017151294,
-0.0031009933,
-0.0119584,
0.024978312,
-0.03551481,
-0.000254116,
-0.026118455,
0.0056745065,
-0.011165542,
-0.018596131,
-0.01718078,
-0.639948,
0.004704729,
0.02172825,
-0.0027651752,
-0.010877229,
0.014415605,
0.012082898,
0.00856418,
-0.012711943,
0.00789582,
0.004160868,
0.0031173746,
-0.01790156,
-0.016171688,
-0.003097717,
-0.03153086,
-0.023431912,
-0.023235334,
-0.0025800657,
-0.0011294954,
-0.033889778,
0.021269571,
0.0029879618,
0.007260223,
0.024807947,
0.00511754,
0.03323452,
-0.0058186627,
0.0075419825,
0.032422006,
-0.013406513,
-0.0020132703,
-0.010916545,
-0.0077057965,
0.04930137,
0.0076926914,
-0.0043246816,
0.011394881,
-0.0029879618,
0.045658153,
-0.015608169,
0.0012589083,
0.018700972,
-0.0039282525,
-0.025685988,
0.017731195,
0.013196832,
0.027075129,
-0.0145990765,
-0.0383193,
0.0054746536,
-0.0026488674,
-0.019225176,
0.008420024,
0.018032612,
0.018150557,
0.018727181,
-0.027599331,
0.016093059,
0.026380558,
0.022160716,
0.005022528,
0.00072733284,
-0.005287906,
-0.006985016,
0.014821864,
-0.022750447,
0.012921625,
0.003181262,
0.008931123,
0.032212324,
0.03145223,
-0.0045409156,
0.016866257,
0.029643727,
0.0011827348,
-0.0037120185,
0.033784937,
-0.016525526,
-0.0007867153,
-0.0052551436,
0.0045638494,
-0.035121657,
0.0022032943,
0.0048521617,
-0.027887644,
0.0025423886,
0.014848074,
0.02661645,
0.014743233,
0.006215092,
-0.0031255654,
-0.02461137,
-0.016735207,
-0.05608981,
0.03022035,
-0.03132118,
-0.006945701,
0.012607102,
-0.024663791,
-0.020037692,
0.0040625795,
0.018871337,
0.005127369,
0.035043027,
0.006077488,
-0.01856992,
0.037297104,
0.026839236,
-0.014756338,
-0.019343121,
-0.004354168,
0.008800072,
0.018412659,
0.018137453,
-0.015962007,
0.0122991325,
-0.017429776,
0.00397412,
-0.009488089,
0.01435008,
-0.013642405,
0.016014427,
0.017809825,
0.014861179,
0.016355159,
0.01640758,
-0.04631341,
-0.0027291363,
-0.017010415,
0.003528547,
0.0040330933,
0.027022708,
-0.0077189016,
0.015608169,
0.036196273,
0.031976435,
-0.009350486,
-0.008452787,
-0.04125484,
-0.029460255,
-0.008112054,
0.021413727,
-0.010995176,
-0.008446234,
0.010687206,
-0.02067984,
-0.00027623086,
0.0022049323,
-0.004321405,
-0.01031371,
0.008361051,
-0.017704984,
0.013472038,
0.01000574,
-0.02047016,
-0.006015239,
-0.016237214,
0.015267436,
-0.0042296695,
0.00045376393,
0.021466147,
0.00062986364,
0.006958806,
-0.019356227,
-0.029669937,
0.013144411,
-0.0010869039,
-0.014979124,
-0.036143854,
-0.0020493094,
-0.014441815,
0.00084118336,
0.025423886,
0.0006028344,
0.014808758,
0.005094606,
-0.0077778744,
-0.009855032,
0.015149491,
-0.0028307007,
-0.009763297,
-0.013524459,
0.020339109,
0.047073506,
0.026799921,
0.01167664,
0.03973465,
-0.008144817,
0.009330829,
-0.0021443213,
0.02535836,
-0.017324938,
0.021649618,
-0.012390868,
-0.036458377,
0.026249507,
0.013209936,
-0.011578352,
0.019146545,
0.0065001277,
-0.009488089,
0.0022983062,
-0.013406513,
0.016840048,
-0.02731102,
0.005998858,
-0.015346067,
-0.006755677,
-0.0101040285,
0.0048030177,
-0.003407325,
0.0023540028,
0.03003688,
0.0136293,
0.01707594,
-0.02407406,
-0.000502089,
0.005956266,
-0.02335328,
0.021898614,
-0.012482604,
0.0044557326,
0.0035580336,
-0.024309952,
0.023091178,
0.011185199,
0.0046588616,
-0.023562962,
-0.040049173,
-0.0035613098,
0.030430032,
-0.006519785,
0.017246306,
0.011951847,
-0.003407325,
-0.0147956535,
-0.0038660034,
0.01368172,
0.010549602,
0.00342043,
0.015188806,
0.029669937,
0.021256465,
0.011224515,
-0.0039970544,
-0.01337375,
0.007116067,
-0.027101338,
0.03142602,
0.012161529,
0.016957995,
-0.01728562,
-0.0010909992,
-0.024244428,
0.008164475,
-0.0041772495,
-0.012862652,
0.021020574,
0.02998446,
0.013354093,
0.001267918,
-0.0064673647,
-0.012941282,
-0.0038496219,
0.0052682487,
0.013576879,
-0.012364658,
0.016342055,
-0.013282015,
-0.00011200761,
0.013550669,
0.008079291,
-0.023589173,
0.005199447,
0.017364252,
0.013760351,
0.006123356,
-0.0069194906,
0.0017659117,
-0.011683193,
-0.038712453,
0.01301336,
0.016840048,
-0.009638798,
0.0072274604,
-0.02731102,
0.017547723,
0.00070726563,
0.0073847217,
-0.005166684,
0.010064714,
0.0015423059,
-0.018255398,
-0.013983137,
-0.00447539,
0.005969371,
-0.00067163614,
0.017875351,
-0.015699904,
-0.024834156,
0.019120336,
-0.022907708,
0.0021230255,
0.028228376,
0.020457055,
0.011715956,
-0.014061768,
0.020103216,
-0.018845128,
0.01231879,
0.019696958,
0.027756592,
-0.016079953,
0.023012549,
-0.0022049323,
0.0032254916,
0.02047016,
0.016853154,
-0.0047309394,
-0.012430184,
-0.030718345,
-0.01507086,
-0.009560168,
0.0259743,
0.024257533,
0.00550414,
0.01777051,
0.020810893,
0.029512675,
-0.025043838,
-0.0066442834,
0.004796465,
-0.014481131,
-0.016892469,
-0.0030534873,
-0.00961914,
0.014559762,
0.02530594,
-0.006624626,
0.00012992474,
-0.040652007,
0.007070199,
-0.0058645303,
0.029538887,
0.010045056,
0.028280796,
0.017062835,
-0.011447301,
0.0026292098,
0.010405446,
0.022658711,
-0.0036890844,
-0.023982326,
0.011827349,
-0.03381115,
-0.016446896,
0.001567697,
-0.016289635,
-0.03952497,
-0.00080063945,
-0.013386855,
0.016892469,
0.012207396,
0.020417739,
0.019513488,
-0.0072405655,
-0.0056876116,
-0.0056745065,
-0.012928177,
0.007738559,
0.025109364,
-0.025685988,
-0.0005479568,
0.015450908,
-0.008295526,
0.022370398,
-0.0009402906,
0.0316357,
-0.010870677,
0.0092063295,
0.01226637,
-0.01846508,
-0.04639204,
-0.017338041,
-0.015464013,
0.011394881,
-0.003961015,
0.009756744,
-0.011421091,
-0.003348352,
-0.02746828,
-0.0017528066,
0.0028208718,
0.009049068,
-0.04135968,
-0.013825876,
-0.0036071776,
-0.011460407,
0.0031484992,
-0.012194292,
-0.004481943,
-0.014507341,
0.029067103,
-0.0064411545,
-0.013078885,
-0.007260223,
-0.010759284,
0.018373344,
-0.011722508,
0.008223448,
-0.0056417435,
-0.017639458,
-0.026917867,
-0.0026161047,
-0.015699904,
0.024349269,
-0.018242294,
-0.0059824763,
0.006958806,
0.009081831,
0.015005334,
0.018543711,
0.0031632425,
0.005546732,
-0.013904506,
-0.03423051,
-0.02602672,
0.001770826,
0.0155295385,
-0.021846194,
-0.004675243,
-0.0058645303,
0.00006424569,
0.013485144,
-0.011630773,
-0.011643877,
0.02407406,
0.0026586964,
0.002511264,
-0.007882715,
0.018674761,
-0.012148424,
-0.030796975,
-0.014245239,
-0.040075384,
0.025869459,
0.025070049,
-0.033968408,
0.00081579224,
0.014966019,
-0.0014644945,
-0.012639865,
0.007836848,
-0.0014137122,
0.023576068,
-0.011788034,
-0.032369588,
-0.03989191,
-0.007882715,
-0.034492612,
0.018832022,
-0.008741098,
-0.022999443,
-0.018399555,
-0.009075278,
-0.0006085679,
-0.035934173,
0.02178067,
-0.031242548,
-0.010706863,
0.009946768,
-0.0036923608,
0.02239661,
-0.010320263,
0.0056057046,
-0.031766754,
0.007102962,
-0.022947023,
-0.008610048,
-0.016171688,
-0.0020378423,
0.04382344,
0.013786561,
0.024296848,
0.0069981213,
0.02178067,
0.012508814,
0.013825876,
0.013838981,
-0.014258345,
0.009167015,
-0.0055434555,
0.023235334,
0.009684666,
0.0052682487,
0.032186117,
0.0074633523,
0.018255398,
0.002285201,
-0.004363997,
-0.050873984,
-0.010660996,
-0.01771809,
-0.017678775,
0.02239661,
-0.011237619,
0.006755677,
-0.031661913,
-0.024873473,
0.017390462,
0.01843887,
0.00055409985,
-0.020326003,
0.020928837,
-0.0316357,
0.018596131,
0.012043583,
0.005690888,
-0.013472038,
-0.015241226,
0.009062174,
0.01710215,
-0.002152512,
-0.007994109,
0.018071927,
-0.004711282,
-0.035986595,
-0.0234057,
0.0057334793,
-0.024807947,
0.037637834,
-0.0048750956,
-0.02554183,
-0.019919746,
-0.007057094,
-0.016866257,
-0.03533134,
0.0077909795,
0.02469,
-0.035750702,
0.025633568,
0.0019215347,
-0.027573122,
0.037506785,
0.0011745442,
0.017246306,
-0.022540765,
0.026996497,
0.0022196756,
0.005608981,
0.0030698688,
0.0005966914,
-0.0023720223,
0.01095586,
0.002845444,
-0.015581959,
0.028857421,
-0.041595574,
0.009881242,
0.024401689,
-0.018753393,
-0.029224364,
0.021033678,
0.0035482047,
0.026354348,
-0.023707118,
0.002393318,
-0.021623408,
0.022108296,
0.01640758,
-0.010510287,
0.0021607026,
-0.021426832,
-0.027992485,
0.021636514,
0.0063330377,
0.0069915685,
-0.014939809,
0.00083749753,
-0.0054386146,
0.0086166,
-0.024100272,
0.004305024,
0.005602428,
0.027206179,
-0.011375223,
0.009016306,
0.004128105,
-0.016211003,
0.028438058,
-0.0025161784,
0.005225657,
0.032343376,
-0.008131712,
-0.016551737,
0.026249507,
-0.009520852,
0.01833403,
-0.020312898,
0.011584905,
0.006182329,
-0.020719156,
-0.0086166,
0.015621274,
0.010706863,
-0.034047037,
0.021453042,
-0.0125677865,
0.010444761,
-0.052367963,
-0.024257533,
0.032369588,
-0.017442882,
-0.0057858997,
-0.035750702,
0.010536497,
0.0039511863,
0.011407986,
0.0011499722,
-0.004734216,
0.022566974,
-0.029355414,
0.022082087,
-0.014507341,
0.019644538,
-0.018268503,
-0.009042516,
-0.019565908,
0.0028290625,
0.021439936,
-0.022134507,
-0.035121657,
-0.006234749,
0.024113376,
0.028202167,
0.011106568,
0.01198461,
0.005703993,
0.00008021752,
0.015621274,
-0.0019542973,
-0.0072143553,
-0.012017373,
-0.012718496,
0.004459009,
0.014114188,
-0.017246306,
-0.010752731,
-0.00923254,
-0.00497666,
0.01126383,
-0.010031951,
0.011860112,
-0.03847656,
0.012967492,
-0.007712349,
-0.02039153,
-0.0029502846,
0.0021475975,
-0.02717997,
0.0092390925,
-0.009527405,
-0.029093312,
0.0038496219,
0.0021361306,
-0.0022770104,
0.023012549,
-0.028202167,
-0.01237121,
0.010988623,
-0.011643877,
-0.029302994,
-0.02001148,
-0.012358106,
0.026498504,
0.007967899,
-0.031845383,
-0.005238762,
0.013327883,
-0.027809013,
-0.0062019867,
-0.009972977,
0.0043312344,
-0.008931123,
-0.00028237386,
-0.024126481,
-0.0059726476,
0.003479403,
0.0029044168,
-0.0134982485,
-0.0008886893,
0.0016725379,
-0.017927771,
0.017338041,
0.010792047,
-0.0057334793,
-0.034807134,
0.027048917,
-0.021610303,
0.00088213675,
0.009042516,
-0.024060955,
0.026275717,
-0.03286758,
0.029355414,
0.020994363,
-0.008046529,
0.014258345,
-0.0050847773,
-0.021033678,
0.004599889,
-0.0038299642,
-0.023392595,
-0.0036628742,
-0.005510693,
-0.0030878882,
0.0130330175,
-0.007476457,
-0.024807947,
0.020706052,
-0.0012580892,
0.017757405,
0.034518823,
-0.0029896,
-0.004196907,
0.017652564,
-0.0016635281,
-0.012515366,
-0.0041805254,
-0.020941943,
0.0113359075,
0.015359173,
0.00925875,
-0.006985016,
0.016079953,
0.006722914,
-0.016866257,
0.020430844,
0.010444761,
0.006382182,
-0.019447962,
0.02512247,
-0.009782954,
-0.00087722234,
-0.019094124,
-0.0014391034,
0.00959293,
0.001674176,
-0.0007703339,
-0.009573272,
-0.010923097,
-0.013105095,
0.0011507912,
-0.021256465,
0.0074633523,
-0.015581959,
-0.027835224,
-0.014651497,
-0.008144817,
0.1753986,
-0.014808758,
0.002714393,
0.012803678,
0.0000865653,
0.013721035,
0.018412659,
-0.001363749,
0.0071291723,
0.0052453144,
0.007849952,
-0.009140804,
-0.03582933,
0.00394791,
-0.010549602,
0.013458934,
-0.008125159,
0.0026718015,
0.003133756,
-0.0138651915,
0.008701784,
-0.006434602,
-0.008288973,
-0.0038004778,
0.045684364,
-0.0033090366,
-0.022317978,
-0.026223296,
0.020981258,
0.026813027,
-0.013930717,
-0.003970844,
-0.010680653,
0.0102023175,
-0.009029411,
0.021806879,
-0.006742572,
0.005851425,
0.019945955,
0.018189874,
0.0147301275,
0.009920558,
-0.020509476,
0.00056843355,
-0.0097043235,
0.0049570026,
0.0036071776,
0.010680653,
0.00039253858,
0.018661657,
-0.041595574,
0.010038503,
0.038633823,
0.03847656,
-0.0020132703,
-0.015123281,
0.018189874,
0.013216489,
-0.0144025,
0.025436992,
-0.022881497,
0.018124348,
-0.013203384,
0.034545034,
-0.006192158,
0.035174076,
-0.009291513,
-0.0009140804,
0.013118201,
0.003911871,
0.0042493274,
-0.006637731,
-0.03666806,
-0.0074633523,
-0.014074873,
-0.012548129,
0.024178902,
0.010398894,
-0.011683193,
0.028857421,
0.014061768,
-0.007987556,
-0.016250318,
0.01095586,
-0.012685733,
-0.03284137,
0.013196832,
-0.0047538737,
-0.035934173,
-0.016866257,
0.0040265406,
0.0053501553,
-0.032238536,
-0.0070964093,
-0.0037709912,
-0.036615636,
0.013642405,
0.0019198966,
0.0035187183,
-0.015057755,
-0.0060578305,
0.045920257,
-0.0042001833,
0.03323452,
-0.010765837,
-0.01790156,
-0.0016152031,
0.010628233,
0.009363591,
0.013878296,
-0.008773861,
-0.010418551,
-0.006234749,
-0.016446896,
0.0003343847,
-0.007810637,
0.026341243,
-0.018884443,
0.044924267,
-0.021374412,
-0.029224364,
-0.014205924,
0.00043287768,
0.018910654,
0.00008303307,
-0.00928496,
-0.00686707,
-0.0036759793,
-0.010778941,
-0.036091436,
-0.013196832,
-0.026105352,
-0.010405446,
0.0064280494,
0.012554682,
-0.0024309952,
0.0076468233,
0.024008535,
0.008511759,
0.029276785,
-0.021872405,
0.0055074166,
0.032422006,
0.002283563,
0.010484077,
-0.018714076,
0.004593336,
0.0068605174,
0.0018052269,
-0.0059398846,
-0.019172756,
-0.026603345,
-0.0118011385,
-0.007424037,
0.024192007,
-0.03572449,
-0.02178067,
-0.06578758,
0.0130657805,
-0.022370398,
-0.02893605,
-0.009350486,
0.03027277,
-0.0037578861,
0.0040199882,
0.0066082445,
-0.16344675,
0.015319857,
0.018779602,
-0.03323452,
-0.0027438793,
-0.000825621,
0.012240159,
0.009894348,
-0.0052453144,
0.024925891,
0.029329205,
-0.038345512,
-0.020299794,
-0.013203384,
0.0017036624,
0.0023245164,
0.0066279024,
-0.00006322185,
0.007915478,
0.007640271,
0.000873127,
-0.01846508,
0.03134739,
-0.011617667,
-0.016918678,
0.02893605,
-0.01646,
0.005248591,
-0.0081382645,
0.0035580336,
-0.002345812,
-0.006742572,
0.020260477,
-0.008623153,
0.016145479,
-0.005936608,
-0.014703917,
-0.017600143,
-0.009841927,
0.02656403,
0.011093464,
0.017927771,
-0.0092718555,
0.012829889,
-0.0057236506,
-0.00068678893,
0.012240159,
0.0029371795,
0.023340175,
-0.011814244,
0.026380558,
-0.014703917,
0.022947023,
0.037716467,
-0.0013555584,
0.0049078586,
0.0059136744,
0.015149491,
-0.0021918272,
0.0025522173,
-0.017757405,
-0.016669681,
0.022147613,
0.010772388,
0.0097370865,
-0.030718345,
-0.01584406,
0.009422564,
-0.036170065,
0.00047301204,
0.00015869451,
-0.01843887,
-0.0077909795,
-0.027101338,
0.01784914,
0.027075129,
-0.010680653,
-0.008767309,
-0.006431326,
0.01977559,
0.002236057,
-0.009691218,
-0.037873726,
-0.03297242,
-0.010221975,
0.0018510948,
0.022645606,
0.038869713,
0.0035940725,
0.00074576185,
0.018818917,
-0.01584406,
-0.008223448,
-0.013223042,
0.023549857,
0.010431657,
0.016918678,
-0.0017855694,
0.029512675,
-0.01100828,
0.015647484,
0.0020722433,
-0.010837914,
0.0012286027,
0.01707594,
-0.0057334793,
-0.03829309,
0.0042132884,
0.00820379,
-0.021990351,
0.009468432,
-0.021204045,
-0.0026849066,
0.028071115,
-0.02044395,
0.036170065,
-0.01098207,
-0.021387516,
0.06133185,
-0.0042394986,
0.048279174,
0.015201911,
-0.00009639412,
-0.0041182763,
-0.031819172,
-0.037768885,
-0.12801057,
-0.046365827,
0.036537006,
-0.02172825,
-0.01134246,
0.023235334,
-0.0069915685,
-0.013956927,
-0.03003688,
0.016394475,
-0.006742572,
-0.0015292008,
0.016853154,
-0.012954387,
0.042014938,
-0.014743233,
0.019421753,
-0.012823336,
-0.025201099,
0.030534873,
0.010523392,
-0.0032713595,
0.014468025,
0.0017216819,
0.009108041,
0.030063089,
-0.0081710275,
0.029643727,
-0.000051550123,
-0.004626099,
0.016813837,
-0.018674761,
0.045029107,
-0.006349419,
-0.025633568,
-0.025489412,
-0.023143599,
-0.023012549,
0.026485398,
-0.0056188097,
-0.010372683,
0.019893536,
0.024794841,
-0.00052911823,
0.00017159485,
-0.008583838,
-0.009697771,
0.03273653,
0.03142602,
-0.02851669,
-0.03564586,
-0.006185605,
-0.022829076,
-0.016145479,
0.01913344,
-0.014677707,
0.011093464,
0.016302738,
-0.0059005693,
-0.0035580336,
-0.012220502,
0.03268411,
-0.017783616,
-0.005497588,
0.015595064,
0.009835375,
-0.027075129,
-0.04822675,
0.028018694,
-0.02592188,
-0.01432387,
0.02600051,
0.0016938336,
-0.0119584,
-0.027520701,
-0.007810637,
-0.012521919,
0.0075681927,
0.017914666,
-0.0073519587,
-0.020365318,
-0.013131306,
0.022475239,
0.018648552,
0.0016905573,
-0.008177579,
0.030639714,
0.014926705,
0.0014939809,
-0.018661657,
-0.025594251,
0.019592118,
0.021741355,
-0.023418806,
-0.033286944,
0.007030884,
-0.004891477,
-0.003204196,
0.028438058,
0.0041084476,
-0.015778536,
-0.010516839,
-0.04403312,
0.0011737251,
-0.018255398,
0.011014833,
0.00023650602,
0.0035482047,
0.006090593,
-0.007043989,
0.003528547,
-0.011571799,
-0.03268411,
0.033837356,
-0.015319857,
-0.016276529,
-0.021570988,
-0.03540997,
0.015948901,
0.0015734306,
0.006421497,
0.017731195,
0.003492508,
0.020732261,
0.0010500458,
0.01905481,
-0.021846194,
0.004865267,
-0.024545845,
-0.0021377688,
0.015319857,
-0.00016514468,
0.010163002,
-0.043613758,
-0.02268492,
0.007849952,
-0.02864774,
-0.019592118,
-0.008786967,
0.018085033,
0.009291513,
0.024296848,
-0.010628233,
-0.012810231,
-0.0014735042,
-0.028359428,
0.0022655434,
0.0070112264,
-0.012757811,
-0.0013907783,
0.0088721495,
0.008610048,
0.008413471,
0.02677371,
0.004691624,
-0.016695892,
-0.0048390566,
-0.0049209637,
-0.011021386,
-0.015372277,
-0.031871594,
0.004016712,
0.015359173,
0.00964535,
0.029171944,
-0.006827755,
0.0021819985,
-0.0047407686,
-0.029093312,
-0.018019507,
0.035881754,
0.013131306,
-0.027127549,
-0.014336974,
-0.0015373916,
0.015752325,
0.0145990765,
-0.0026505056,
-0.021977246,
-0.0061987103,
-0.020850208,
0.006054554,
0.015411593,
0.01499223,
-0.020234268,
0.019841116,
0.03278895,
0.0026210193,
-0.02201656,
0.006729467,
0.024231322,
0.0066344547,
-0.002178722,
0.024178902,
0.007882715,
-0.0020591381,
0.01905481,
0.010949307,
-0.016289635,
0.006618073,
0.012810231,
0.014166608,
0.005677783,
-0.0041444865,
-0.009225988,
0.0015103623,
-0.0053992993,
-0.008623153,
-0.029565096,
-0.049825575,
0.01576543,
-0.023366386,
0.033339363,
-0.02535836,
0.012443288,
0.00028483107,
-0.024034746,
0.004265709,
-0.008112054,
-0.00828242,
-0.0059857527,
0.0027373268,
0.010064714,
0.022383504,
-0.0018052269,
-0.019749379,
0.01643379,
0.004855438,
0.027206179,
0.0054943115,
0.01718078,
-0.026446084,
-0.0016987481,
-0.011565247,
-0.02875258,
-0.029486466,
0.011001728,
0.009651903,
-0.00564502,
0.0017528066,
-0.007640271,
0.058501147,
0.00069661776,
0.004626099,
-0.0022688196,
0.024296848,
-0.0061495663,
0.0077909795,
0.010752731,
-0.04107137,
0.0060840407,
0.030377612,
-0.020955049,
0.02268492,
-0.04193631,
-0.021715144,
0.0024916064,
-0.012888862,
0.0007760674,
0.0071553825,
-0.010988623,
0.011860112,
-0.007070199,
0.015411593,
-0.016577946,
-0.046208568,
0.010654443,
0.046863824,
0.0068212026,
0.022475239,
-0.04002296,
0.0011704488,
0.021977246,
-0.021269571,
-0.01990664,
0.007070199,
-0.008793519,
-0.021715144,
-0.002178722,
-0.0004807932,
0.022920813,
-0.020260477,
0.025672883,
-0.0013072334,
0.0027111168,
0.011407986,
0.0054812063,
-0.019198965,
-0.0077844267,
0.0012138595
] |
Maternal undernutrition contributes to 800,000 neonatal deaths annually through small for gestational age births; stunting, wasting, and micronutrient deficiencies are estimated to underlie nearly 3·1 million child deaths annually. Progress has been made with many interventions implemented at scale and the evidence for effectiveness of nutrition interventions and delivery strategies has grown since The Lancet Series on Maternal and Child Undernutrition in 2008. We did a comprehensive update of interventions to address undernutrition and micronutrient deficiencies in women and children and used standard methods to assess emerging new evidence for delivery platforms. We modelled the effect on lives saved | [
-0.0059016603,
-0.021449953,
0.0065967375,
-0.03016765,
0.008899586,
-0.023814514,
-0.021553889,
-0.005450185,
-0.031492844,
-0.022333415,
0.031518828,
0.021969637,
-0.015785398,
0.01468107,
-0.015252722,
0.0003201334,
0.045316435,
-0.009627144,
0.0058172117,
-0.023528688,
-0.03289599,
0.012251548,
-0.009432263,
0.009152932,
-0.0009809034,
0.018682636,
0.0086397445,
-0.03809283,
0.0038196766,
-0.010789936,
-0.010166316,
-0.015967287,
-0.0056483145,
-0.022021605,
-0.015005873,
0.0013828464,
-0.0170976,
-0.009529703,
0.0022460087,
-0.016240122,
0.0022362648,
0.029647967,
0.009958442,
0.028946392,
-0.016305082,
0.014304299,
-0.0011221924,
0.015447604,
-0.02651687,
0.0037092438,
0.004550482,
0.021761762,
-0.015135793,
0.008951555,
-0.0057230187,
0.0047551077,
-0.032116465,
0.01065352,
0.027075531,
-0.016162168,
-0.006651954,
0.011764344,
-0.03993771,
0.009971434,
-0.027881041,
-0.015954295,
0.002013775,
0.011348597,
-0.0023613137,
0.009425767,
0.034013312,
0.03307788,
-0.0005655622,
-0.005086406,
0.0028371492,
-0.021423968,
-0.0090619875,
0.0068663233,
0.008282462,
0.0019747987,
0.011926745,
-0.0019098383,
0.0033584572,
0.021943653,
-0.010471631,
-0.017916102,
-0.0068858117,
0.01902043,
0.017487362,
-0.0014185746,
-0.0013268179,
-0.0048428043,
0.030531429,
0.0041022548,
0.0019341984,
0.019644052,
0.0025935473,
0.025412543,
0.0054371925,
-0.0024879866,
-0.02656884,
0.0051448704,
-0.018942477,
-0.008379903,
0.009750569,
-0.012284028,
-0.026179075,
0.016071225,
0.0073730154,
0.0014080185,
-0.040743217,
0.019722003,
-0.009620648,
-0.030219618,
0.0025675632,
-0.0067428984,
0.011296629,
0.026659783,
-0.004859044,
-0.0052780397,
0.02031964,
0.0071456535,
0.05105894,
-0.016564924,
-0.008912579,
-0.009230885,
-0.024659,
-0.017604291,
-0.01617516,
-0.012524382,
0.01468107,
0.00956868,
0.029440092,
-0.0004161531,
-0.042718016,
0.03458496,
-0.007457464,
-0.01492792,
-0.042588096,
-0.033935357,
0.015655477,
0.030479461,
-0.008392895,
-0.01740941,
-0.006385616,
0.022229478,
0.016889727,
0.026841672,
-0.017916102,
-0.005232567,
-0.0017230769,
-0.0055606174,
0.023138925,
-0.0053787283,
0.006158254,
0.0101273395,
0.02526963,
0.025438527,
-0.032246385,
-0.024139317,
0.000033216125,
-0.019670036,
-0.028634582,
0.017851142,
-0.00478434,
0.00792518,
-0.004962981,
-0.014265323,
0.014862959,
-0.008081084,
0.028296787,
0.049032174,
-0.015382643,
0.008379903,
-0.0126867825,
0.018747596,
0.009594664,
0.04412116,
-0.011517494,
-0.005976365,
-0.013771623,
0.015252722,
0.0020738635,
0.012089146,
-0.032636147,
0.006931284,
0.020826332,
0.0028761255,
0.012011194,
-0.0032821286,
-0.00081890816,
0.00901002,
-0.01902043,
-0.0040535345,
-0.647734,
0.0124594215,
0.0011197564,
0.008425375,
-0.0066194735,
0.002395418,
0.0072625824,
0.003881389,
-0.012829696,
0.027153483,
-0.012407453,
0.009094468,
-0.0026861161,
-0.03177867,
-0.004326368,
-0.020059798,
-0.032402292,
-0.0013958385,
0.004660915,
-0.017006656,
-0.0109783225,
0.017708229,
0.0061809905,
0.012680287,
-0.0021599361,
0.005742507,
0.022658218,
-0.0015241354,
0.01065352,
0.021008221,
0.0023791778,
0.012849184,
-0.010257261,
0.020605465,
0.045758165,
-0.019864917,
-0.017942086,
0.027725136,
-0.0090619875,
-0.004436801,
-0.046147928,
0.0046154424,
0.024996795,
-0.005921148,
0.0032236641,
0.024581049,
0.012992097,
0.008068092,
0.013472805,
-0.02211255,
0.011374582,
0.01729248,
-0.012277532,
0.0010369318,
0.0032139202,
-0.0040795184,
0.0154605955,
-0.009562183,
0.013433829,
0.014694062,
-0.0048687886,
-0.013641702,
-0.007762778,
-0.00047705357,
-0.028140882,
0.036715668,
-0.0131090265,
0.05168256,
-0.0030287828,
-0.0010028275,
0.0065934896,
0.046797533,
0.012712767,
0.009016516,
0.035598345,
0.00010018125,
0.0099129705,
0.006424592,
-0.009861002,
0.019838933,
-0.004388081,
-0.013914536,
-0.0074119917,
0.013810599,
0.023814514,
-0.0028923657,
0.00480058,
-0.0067493943,
-0.001995911,
-0.006301167,
-0.008081084,
-0.0022184006,
0.0026016675,
-0.045056593,
-0.0035435946,
0.013485797,
-0.010789936,
0.02589325,
0.023801522,
0.0019130863,
-0.041704632,
0.014148394,
-0.010802929,
0.00532676,
0.026231045,
0.025230654,
-0.023333807,
0.010166316,
0.02309995,
-0.023151917,
-0.0051221345,
0.01205017,
-0.022541288,
-0.010250765,
0.023619633,
-0.013368868,
-0.010698992,
-0.002518843,
-0.0266338,
-0.029284187,
0.02837474,
0.0019147104,
0.015317683,
0.0057132747,
-0.013420836,
0.0029492062,
0.00588542,
0.0059471326,
0.0014177626,
-0.040899124,
0.0004997897,
0.015603509,
0.025295613,
-0.0086267525,
0.03258418,
0.0006776191,
0.016123192,
-0.02112515,
-0.009510215,
-0.0012740375,
-0.013667686,
0.008094077,
0.0058302036,
-0.023268847,
0.009763561,
-0.023307823,
0.017864134,
-0.0074509676,
0.0069182916,
0.008295454,
-0.033311736,
-0.0065545132,
-0.023086958,
0.008438367,
0.008477343,
-0.0071261656,
-0.018357834,
-0.037936922,
0.009100964,
-0.031051112,
0.013011585,
0.033935357,
-0.023671601,
-0.01093285,
-0.01090037,
-0.015577525,
-0.016460987,
0.018383818,
-0.0035468426,
-0.023320815,
0.012589342,
-0.042146362,
-0.01328442,
0.017357443,
0.0067623868,
0.02576333,
-0.004667411,
0.018877517,
-0.020202711,
0.010497615,
0.018188937,
-0.032558195,
-0.027907025,
0.0020998477,
0.014655085,
0.029206235,
0.018552715,
-0.016460987,
-0.0028014209,
0.025750337,
-0.0143952435,
0.0053787283,
-0.024295222,
0.008217501,
0.012842688,
-0.007223606,
-0.029258203,
0.0040535345,
-0.022411367,
0.020657435,
0.02267121,
-0.000042884072,
0.009783049,
-0.001997535,
0.006301167,
0.0064440803,
0.005105894,
-0.012108634,
0.007048213,
-0.0026260277,
0.0036637713,
0.011238164,
0.0058302036,
-0.0030482707,
0.0029881825,
0.008958051,
-0.0122645395,
-0.025230654,
-0.024230262,
-0.013940521,
0.010673008,
-0.033545595,
0.0047096354,
-0.0065057925,
-0.0099129705,
0.018578699,
0.005999101,
0.007210614,
-0.0008245922,
-0.020202711,
0.010854897,
0.0031457115,
-0.0024457623,
-0.0016922207,
-0.012751743,
-0.007522424,
-0.0035046183,
-0.028192852,
0.023866482,
0.021839716,
-0.008672225,
-0.007080693,
0.019488147,
0.019864917,
0.008340927,
-0.009536199,
0.033987325,
0.012569854,
-0.02936214,
0.00016960777,
0.011588951,
0.011478518,
-0.035754252,
-0.004514754,
-0.015525556,
-0.032947958,
-0.004518002,
0.0036605233,
0.030427491,
0.03728732,
0.015109809,
-0.013011585,
0.0034364096,
-0.025204668,
0.011718872,
-0.014772015,
0.01043915,
0.0025058507,
0.007749786,
-0.006944276,
-0.03481882,
-0.008061596,
0.011036786,
-0.012134619,
0.008678721,
0.0021242078,
0.019929877,
0.0090425,
0.005765243,
0.010705488,
-0.01946216,
0.0033324729,
0.028790487,
0.02484089,
-0.018929485,
0.0067753787,
-0.03214245,
0.023385774,
-0.00003281012,
-0.0041087507,
0.026893642,
0.007606873,
0.010380685,
-0.006155006,
-0.01729248,
-0.0027559486,
0.016642876,
-0.027205452,
-0.0086332485,
0.003618299,
0.032792054,
-0.013303908,
-0.015200754,
0.01685075,
0.011783832,
-0.00043523527,
0.0020738635,
-0.018968461,
-0.004621939,
-0.010400174,
0.004095759,
-0.015941303,
0.018474761,
0.004686899,
0.0099129705,
-0.0006971072,
-0.0051805987,
0.025477502,
0.009399782,
0.0075549046,
0.0023889218,
-0.016954686,
-0.009653129,
0.010114348,
0.057061292,
0.028530646,
0.00070400926,
0.02316491,
0.010588559,
0.006531777,
-0.009113956,
-0.0006390488,
0.010445646,
-0.004933749,
0.011368085,
0.0075484086,
0.0071391575,
-0.019072399,
0.022255462,
0.012569854,
-0.0057132747,
-0.006453824,
-0.02242436,
0.011231668,
0.020631451,
0.012063162,
0.033415675,
0.026477894,
-0.0016256361,
0.0039593414,
0.018552715,
0.019098382,
-0.006580497,
0.00011114333,
0.014512173,
0.0015208874,
-0.026607815,
0.042795967,
-0.011816313,
0.016058233,
0.014875951,
-0.02390546,
0.032999925,
0.015109809,
0.011640919,
0.015447604,
-0.017435394,
0.02255428,
0.015954295,
-0.0030060464,
0.0074184877,
0.033259768,
-0.0141743785,
-0.024555065,
0.033623546,
-0.01542162,
-0.011472022,
-0.025984194,
0.01303757,
-0.005570362,
-0.003881389,
0.015005873,
-0.0088346265,
-0.008555296,
-0.00042711518,
-0.022346407,
0.00025842094,
-0.010582063,
-0.0025821794,
-0.023801522,
-0.032947958,
0.016811773,
-0.031934574,
-0.004794084,
0.0005099398,
0.003910621,
-0.021216094,
0.0111926915,
-0.011725368,
0.021813732,
0.022281447,
-0.013706663,
0.00611603,
0.04022353,
-0.008490335,
-0.008620257,
-0.018435786,
-0.02980387,
0.026607815,
0.0038326688,
0.010224781,
-0.04206841,
-0.05487862,
-0.016629884,
0.0003712898,
0.01244643,
0.016967678,
0.0056678024,
-0.006535025,
-0.011238164,
-0.013472805,
0.00886061,
0.002941086,
-0.022008613,
0.011361589,
-0.0019747987,
-0.030921191,
-0.02076137,
0.0075029363,
-0.023450736,
-0.029232219,
-0.00011895889,
-0.00079698395,
-0.02211255,
0.023580657,
-0.0069052996,
0.023021996,
0.015369651,
-0.0046479227,
0.040509358,
0.033545595,
0.018539723,
0.024723962,
0.0076718335,
-0.007074197,
-0.00068979914,
0.01908539,
0.010660016,
-0.0038229246,
0.016240122,
0.0043620965,
-0.018435786,
-0.04788887,
0.00040783006,
-0.003975582,
0.023944436,
0.015408628,
-0.025828289,
-0.030635366,
-0.01195273,
-0.012810208,
0.002135576,
-0.03580622,
-0.032714102,
-0.0011725368,
-0.020514522,
-0.013193475,
-0.018123975,
0.052514058,
-0.03177867,
0.018201929,
0.009133444,
0.012667295,
0.02558144,
-0.0061322697,
0.007210614,
-0.014862959,
0.012108634,
-0.029414108,
-0.022476329,
-0.010270253,
-0.0022476327,
0.023762546,
0.011498006,
0.043757383,
-0.0004705575,
0.026841672,
-0.009893482,
0.01895547,
-0.008327934,
0.012433437,
0.018227912,
-0.010003915,
0.011783832,
0.01995586,
-0.0013674182,
0.0018107735,
0.0024506343,
0.019864917,
0.015694454,
-0.020683419,
-0.06038727,
-0.010582063,
-0.019903893,
-0.006401856,
0.011309621,
-0.0069832522,
0.008971043,
-0.042354237,
-0.0062297108,
0.019981846,
0.002405162,
0.018916493,
0.000014679547,
-0.017084608,
-0.00027303703,
0.00938679,
-0.0054274485,
-0.015694454,
0.004527746,
-0.026893642,
-0.0038326688,
-0.003608555,
-0.0076718335,
-0.01995586,
0.018422794,
0.030141667,
-0.016681854,
-0.019657044,
0.017760197,
-0.011887769,
-0.03258418,
0.00032764446,
-0.058204595,
-0.0103352135,
-0.0006828971,
-0.005768491,
-0.036455825,
-0.0032350323,
-0.008295454,
-0.024204277,
0.025815297,
-0.012849184,
-0.015512564,
-0.017123584,
-0.01666886,
-0.012563358,
-0.023125933,
0.018695628,
-0.009672617,
-0.002932966,
-0.025373565,
0.014304299,
0.0071261656,
0.003611803,
0.034532994,
0.02012476,
-0.023658609,
-0.019773971,
0.0063563837,
0.025620416,
0.0042484156,
-0.02286609,
0.029206235,
0.025984194,
-0.0114070615,
0.0033682012,
-0.022905067,
-0.014849967,
0.010517103,
-0.0024230261,
-0.027335372,
-0.0055346335,
-0.017435394,
-0.019825941,
0.02410034,
-0.015863352,
0.018682636,
-0.00935431,
0.010101356,
0.0074509676,
-0.033545595,
-0.014382252,
0.016162168,
-0.01833185,
0.014655085,
0.0009735953,
0.021956645,
0.014577134,
-0.0047193794,
0.010302733,
0.010374189,
-0.018721612,
0.029518045,
0.0051416224,
-0.024113333,
0.026088132,
0.024256246,
0.013459813,
-0.011049779,
-0.00532676,
-0.021294048,
-0.02645191,
-0.019046415,
0.0054826653,
0.0008412383,
-0.020631451,
-0.011842296,
-0.009867498,
-0.010348205,
-0.007756282,
-0.027647182,
0.021501921,
-0.018097991,
-0.015785398,
-0.0024798666,
-0.014499181,
-0.02638695,
0.004144479,
-0.028348757,
-0.025321597,
0.008256478,
-0.0031213514,
0.030245602,
0.029076314,
0.00084448635,
0.0010271877,
0.00013184949,
-0.044017226,
-0.020046806,
0.0131090265,
0.0012756615,
-0.053059727,
0.02607514,
0.018747596,
0.00478434,
-0.00346889,
-0.0109783225,
0.0346889,
-0.0030060464,
-0.008100573,
-0.021982629,
-0.036014095,
0.03853456,
-0.020514522,
0.0047226273,
0.014135402,
-0.013979496,
0.0012245051,
-0.019929877,
0.011387574,
0.015902327,
-0.025516478,
0.022411367,
-0.01387556,
0.023424752,
0.003621547,
0.0017230769,
-0.01585036,
-0.015655477,
-0.0118358005,
0.024762938,
-0.0018887261,
0.0013146378,
0.009783049,
-0.0056710504,
-0.016006263,
-0.0021372,
-0.0054274485,
-0.01517477,
0.0058334516,
-0.0166039,
-0.0341952,
0.004141231,
-0.012069658,
0.031934574,
0.011101747,
-0.004972725,
-0.0078017544,
-0.0075743925,
-0.031414893,
0.008802146,
0.0063271513,
0.017682245,
-0.0010344958,
0.0133298915,
-0.004163967,
0.020527514,
-0.013641702,
0.02503577,
-0.024762938,
-0.005463177,
0.018072007,
0.010647024,
0.025178684,
-0.017617283,
-0.00646032,
0.0045927064,
0.027075531,
0.006294671,
-0.00889309,
0.004683651,
0.006275183,
-0.0057035307,
-0.019306257,
0.00096791127,
-0.000112970345,
-0.014421228,
0.032870006,
-0.0053170156,
-0.0261401,
-0.006405104,
0.010692496,
-0.011543479,
-0.010984818,
0.0063271513,
0.0111991875,
0.0007076633,
-0.022320423,
0.010010411,
-0.0040990068,
0.009516711,
0.024710968,
0.030427491,
0.008373407,
0.017812165,
0.013914536,
0.014057449,
0.010634031,
0.016383035,
-0.027725136,
-0.0023434495,
0.01747437,
0.005388472,
-0.026088132,
0.0013178858,
0.006924788,
-0.002960574,
-0.0014892191,
0.009204901,
-0.03993771,
-0.0011579207,
0.014408235,
-0.01573343,
0.012491901,
0.0051903427,
0.026919626,
-0.023697585,
-0.0009500471,
-0.01177084,
-0.01895547,
-0.011088755,
-0.011186196,
0.013485797,
-0.017643267,
-0.0027218445,
-0.012485405,
-0.018240904,
-0.005161111,
0.029907808,
0.16525948,
-0.005625578,
-0.019423185,
0.0166039,
0.0023223374,
0.0060867975,
0.023723569,
0.01114722,
0.002794925,
0.011049779,
0.00080632203,
0.0152397305,
-0.012862177,
0.008821634,
0.0029670703,
-0.026283013,
-0.042718016,
-0.010120844,
-0.010887378,
0.013745639,
-0.015135793,
-0.009666121,
0.0028972377,
0.009113956,
0.036403857,
0.008782658,
-0.031129066,
0.024412151,
0.02112515,
-0.0043653445,
-0.009835018,
-0.0018546219,
-0.0028582613,
0.0015736677,
0.014694062,
-0.00826947,
0.015122801,
-0.006957268,
-0.004540738,
0.009055492,
-0.015122801,
0.03414323,
-0.002398666,
0.008068092,
-0.0076978174,
0.032324336,
-0.009250374,
-0.012485405,
-0.015408628,
0.015083825,
-0.0146031175,
0.00396259,
0.021112159,
0.009718088,
-0.021397984,
0.018604683,
-0.0067818747,
0.0026438918,
-0.0024831146,
0.014330283,
-0.013212963,
0.006401856,
-0.0053819763,
0.024308214,
-0.017435394,
0.044562895,
-0.0035565866,
-0.01908539,
-0.010679504,
-0.019345233,
0.0034039295,
-0.010926354,
-0.022632234,
0.016616892,
-0.019773971,
-0.020241687,
0.020527514,
-0.0010588559,
-0.011023794,
0.02007279,
-0.009490727,
-0.023528688,
-0.0126867825,
-0.0030076704,
-0.0073145507,
-0.022151526,
-0.004092511,
0.014823983,
0.004985717,
-0.0016987167,
-0.007119669,
0.0030482707,
-0.01418737,
-0.00090376276,
-0.008035612,
0.008464351,
0.013979496,
0.0066162255,
-0.0062329588,
-0.028114898,
-0.020553498,
0.08481241,
-0.0069767563,
0.012589342,
0.0032918726,
-0.011543479,
-0.013368868,
0.032506227,
-0.01127714,
0.0069702603,
-0.012219068,
-0.00396259,
-0.009185413,
-0.009464743,
0.00799014,
0.009146436,
0.011660407,
-0.013459813,
0.010984818,
-0.018059015,
0.015109809,
-0.03840464,
0.015317683,
0.034558978,
-0.012595838,
-0.018357834,
-0.00404379,
0.020579481,
-0.029907808,
-0.014291307,
0.0057197707,
-0.03642984,
-0.023957428,
0.002142072,
-0.021475937,
-0.0064278403,
0.016798781,
0.016032249,
0.0077302977,
0.0069832522,
-0.006509041,
0.0032399043,
0.0007921119,
-0.002928094,
-0.0011822808,
-0.028530646,
0.022970028,
-0.0071391575,
0.01734445,
-0.009152932,
-0.015122801,
0.0042484156,
0.01821492,
-0.007048213,
0.01579839,
-0.0041152467,
-0.026101124,
-0.04251014,
-0.00057936634,
-0.0036897557,
-0.02354168,
0.009438759,
0.02069641,
-0.012335996,
-0.011472022,
0.027283404,
-0.1622453,
0.017110592,
0.013732647,
-0.026971593,
0.036273934,
-0.007340535,
0.024918843,
0.012933632,
-0.018539723,
-0.0084188795,
0.017890118,
0.004556978,
-0.026789704,
-0.010458638,
-0.002268745,
0.0011319364,
-0.005872428,
0.03289599,
0.004660915,
0.014836975,
0.034714885,
-0.010828913,
0.008392895,
-0.011036786,
0.017201537,
0.026841672,
-0.0033016168,
0.034169216,
0.013823591,
-0.00079698395,
-0.025685376,
-0.02211255,
0.011933241,
0.0018059015,
-0.015408628,
-0.0024766186,
-0.004134735,
-0.00047136954,
-0.0050052055,
0.010614543,
0.014901935,
0.023697585,
0.000799826,
-0.005570362,
-0.009549191,
0.0059731165,
-0.003316233,
-0.0015907199,
0.01127714,
-0.01765626,
0.0051416224,
-0.010224781,
0.0071326615,
0.0039983178,
0.008282462,
0.005729515,
-0.0068598273,
0.012647807,
0.006632466,
-0.0086397445,
-0.015785398,
-0.008217501,
0.016616892,
0.013271428,
0.022385383,
-0.034117248,
-0.02931017,
0.006814355,
-0.025932226,
-0.003884637,
-0.02905033,
-0.024723962,
0.0006922352,
-0.016655868,
0.011614935,
0.006807859,
-0.001737693,
0.019176336,
0.0069052996,
0.015096817,
-0.014460204,
0.014460204,
-0.023190893,
0.021281056,
-0.012582846,
0.009575176,
0.024931835,
0.013693671,
0.009373798,
-0.007879707,
0.012180091,
-0.032870006,
0.008366911,
-0.028790487,
0.026685767,
0.015122801,
-0.002012151,
0.0070417165,
0.008275966,
0.00373198,
-0.008873602,
-0.008074588,
-0.023138925,
0.0072690784,
0.035546377,
-0.014304299,
-0.014265323,
-0.004404321,
0.036949523,
-0.0063433913,
-0.0004997897,
0.0077367937,
-0.022580264,
0.012030682,
-0.0038229246,
0.034091264,
0.010867889,
-0.0031684476,
-0.011712376,
-0.0063044154,
0.04911013,
0.0052585513,
-0.026490886,
0.015863352,
0.0070287245,
-0.029881824,
-0.123684764,
-0.015252722,
-0.007769274,
0.011127731,
0.002395418,
0.019059407,
-0.0113940695,
-0.0041249907,
-0.01279072,
0.035702284,
-0.025516478,
-0.045706198,
-0.006262191,
0.01254387,
0.045862105,
-0.022216486,
-0.0012975857,
-0.0332078,
-0.017825158,
0.051006973,
0.018072007,
-0.01839681,
0.0013057058,
-0.018435786,
-0.022528296,
-0.015109809,
-0.0074379756,
0.017578308,
-0.0075678965,
-0.0058951643,
0.02497081,
-0.0092633655,
0.04516053,
-0.027803088,
-0.021514913,
-0.0019455666,
-0.0032772566,
-0.002411658,
-0.016266106,
-0.020865308,
0.0007584137,
0.034610946,
0.04063928,
0.003913869,
0.00373198,
-0.014304299,
-0.01436926,
-0.006548017,
0.015369651,
-0.018318858,
-0.037755035,
0.007100181,
-0.036273934,
-0.003611803,
0.0223594,
-0.027283404,
0.013368868,
-0.0044173133,
0.014733038,
0.017396418,
-0.013394852,
0.031622764,
-0.024152309,
0.014785007,
0.008483839,
-0.03648181,
-0.032740086,
-0.036949523,
-0.003913869,
-0.02694561,
-0.012206076,
0.009938954,
0.013901544,
0.010906866,
-0.025100732,
0.016655868,
-0.020085782,
-0.025204668,
-0.007288567,
-0.018059015,
-0.021242078,
-0.019618066,
0.016694846,
0.0154605955,
-0.0055638654,
0.005398216,
0.0011806568,
-0.0015298194,
-0.014823983,
-0.016512956,
0.016564924,
0.02645191,
0.026179075,
-0.018409802,
-0.0027624448,
0.039054245,
-0.0076783295,
-0.018318858,
0.036585744,
-0.007587385,
-0.02459404,
0.00009119843,
-0.043315653,
0.019293264,
0.000017585007,
-0.011790329,
-0.0023629377,
0.0061874865,
-0.018669644,
-0.018617675,
0.004621939,
0.030765286,
-0.030063713,
0.023996403,
-0.017617283,
-0.004969477,
-0.016954686,
-0.012368477,
0.029595997,
0.023892466,
0.027153483,
0.03253221,
0.007717306,
-0.00646032,
0.0048363083,
0.02503577,
0.0017945335,
0.0013016458,
-0.004859044,
0.006112782,
0.0203846,
0.0025838034,
0.026971593,
-0.023307823,
0.0033974333,
-0.004137983,
-0.020098774,
-0.021436961,
0.017890118,
0.005927644,
0.030245602,
0.029414108,
-0.0028452694,
0.0063498877,
-0.023060972,
-0.008951555,
0.0023596897,
0.011679895,
0.016941695,
0.0006134706,
0.0017604291,
0.0052650473,
0.03915818,
0.008113565,
0.010789936,
-0.017279489,
-0.012452926,
-0.0020592473,
-0.0062297108,
0.028530646,
-0.019527122,
-0.019241296,
0.021346016,
0.0010531719,
0.0040567825,
0.019812949,
0.03079127,
-0.031752687,
0.00721711,
0.028010963,
-0.0059536286,
-0.034662917,
-0.0050669177,
-0.009191909,
-0.008769666,
-0.0047161314,
-0.007645849,
-0.012511389,
0.0026049155,
0.007886203,
-0.015005873,
0.017812165,
0.0026909881,
0.025074748,
-0.031648748,
0.022957036,
0.010101356,
-0.011588951,
-0.028348757,
0.026127107,
-0.0033974333,
0.0046414267,
-0.021553889,
0.00432312,
0.002429522,
0.01931925,
-0.002268745,
0.029570013,
0.018305864,
-0.0030986152,
0.0015696078,
-0.01103029,
0.010166316,
-0.008412383,
-0.012030682,
-0.009776553,
-0.021436961,
-0.0025870514,
-0.017383426,
-0.038014878,
-0.0015598637,
-0.00585294,
-0.015694454,
0.026296005,
0.0017441891,
0.003087247,
-0.015395635,
0.022385383,
0.013940521,
0.00910746,
-0.015356659,
0.017578308,
0.021891683,
-0.0026471398,
0.031856623,
-0.021722786,
0.014499181,
0.014616109,
0.0035695788,
-0.024217268,
0.05022745,
0.007353527,
-0.0059698685,
-0.003887885,
-0.03728732,
0.0040762704,
0.011231668,
-0.015018865,
0.039132196,
-0.0061842385,
0.012855681,
0.04955186,
-0.0060218372,
-0.013589733,
0.004254912,
0.00997793,
0.007593881,
0.009958442,
-0.008899586,
0.004683651,
-0.015395635,
-0.005083158,
-0.007191126,
0.009529703,
-0.0175913,
-0.009425767,
0.009445255,
-0.0070287245,
0.023138925,
-0.027127499,
0.0074184877,
0.013771623,
0.011809817,
0.007100181,
0.031051112,
-0.034013312,
-0.0028761255,
0.019683028,
0.022593258,
0.017149568,
-0.029102297,
-0.020241687,
0.004427057,
-0.013368868,
-0.016707838,
0.0028566374,
0.0031375915,
-0.012875169,
0.0041802074,
0.0073925033,
-0.004823316,
0.026659783,
0.0030076704,
-0.029336156,
0.0008988907,
-0.004690147,
-0.038118813,
-0.008971043,
-0.016512956,
-0.030011745
] |
Maintenance of normal endothelial function is critical to various aspects of blood vessel function, but its regulation is poorly understood. In this study, we show that disruption of baseline fibroblast growth factor (FGF) signaling to the endothelium leads to a dramatic reduction in let-7 miRNA levels that, in turn, increases expression of transforming growth factor (TGF)-β ligands and receptors and activation of TGF-β signaling, leading to endothelial-to-mesenchymal transition (Endo-MT). We also find that Endo-MT is an important driver of neointima formation in a murine transplant | [
-0.031222004,
-0.021977283,
-0.0129464995,
-0.02138085,
-0.02173093,
0.0032852471,
-0.038923778,
0.02704697,
-0.02377955,
-0.010521867,
0.0150016025,
-0.0067487764,
0.000913289,
-0.007286863,
-0.016557517,
-0.007293346,
0.028758474,
-0.0015072916,
-0.016764972,
0.017607758,
-0.022236602,
0.030858958,
-0.004683949,
-0.018450545,
-0.0031750367,
0.0005834677,
0.013316029,
-0.051993452,
-0.02282007,
-0.033970784,
-0.0027504019,
0.017698519,
-0.026204182,
0.01421068,
0.014897875,
-0.004038893,
0.014301442,
-0.00680064,
0.028499154,
0.0002641812,
0.017685553,
-0.005795779,
-0.0020648274,
-0.009017818,
-0.010820084,
-0.008894641,
0.014833045,
-0.01469042,
-0.020460267,
0.030029137,
0.010729322,
-0.017529963,
-0.0066969125,
0.007857365,
-0.018230123,
0.00680064,
0.0035040476,
-0.0020923798,
-0.006846021,
-0.011176648,
-0.020940008,
-0.006427869,
-0.030158797,
-0.0041685523,
-0.010333861,
0.01885249,
0.007857365,
0.021717964,
0.0037147442,
0.008369519,
0.031792507,
0.029303044,
-0.010457038,
-0.002951374,
0.0009943262,
-0.021173393,
-0.022029147,
-0.0030129624,
-0.026126387,
0.0018930285,
0.027513742,
-0.01216206,
-0.013847633,
0.039027505,
0.010262548,
-0.00782495,
0.005212311,
0.007909229,
0.02025281,
0.0011320894,
0.021328986,
0.0051280325,
0.0064635254,
0.025361395,
-0.014846011,
0.0037050198,
-0.0102106845,
0.035033993,
0.029328976,
-0.021614237,
0.0041847597,
-0.00891409,
0.025659611,
-0.010119922,
-0.03583788,
-0.007267414,
0.020369506,
0.001846027,
0.02774713,
-0.0041750353,
-0.029303044,
0.01702429,
-0.021419747,
-0.014871943,
0.01301133,
0.025102077,
0.039935123,
0.02086221,
-0.0068914015,
0.0020956215,
0.02160127,
0.0054845964,
0.016401924,
-0.020875176,
0.025257668,
0.017750384,
0.017607758,
0.0063792467,
-0.04836299,
0.005403559,
0.015948117,
0.0063922126,
0.0003156398,
-0.008181513,
-0.030833026,
-0.004181518,
-0.01606481,
-0.014897875,
-0.047896214,
-0.042165264,
0.0017325749,
0.012609385,
-0.02704697,
-0.012038883,
-0.0050048563,
0.0032625569,
0.024012936,
0.00734521,
0.04431761,
-0.00843435,
-0.0074878354,
-0.027513742,
0.004988649,
-0.012836289,
-0.006249587,
0.0055948067,
-0.0034165275,
0.04058342,
-0.0003934355,
-0.0073646586,
0.023247946,
-0.01590922,
0.019306298,
0.0018508892,
0.03337435,
0.007319278,
-0.01571473,
-0.0021328984,
0.016051844,
-0.011870326,
0.0056207385,
0.03075523,
-0.036460247,
0.02591893,
0.0074813524,
0.013497553,
-0.011526728,
0.010029161,
-0.014833045,
-0.031636916,
-0.01612964,
0.03181844,
0.028058313,
0.0043014535,
-0.016038878,
0.008965953,
0.031014549,
-0.012414896,
-0.0045931875,
-0.020395437,
-0.0162593,
0.019034013,
0.0044700108,
-0.009076164,
-0.6447707,
-0.027435947,
0.024025902,
0.0067487764,
0.019604513,
0.0216661,
-0.0038411622,
-0.010437588,
-0.013912463,
0.00830469,
-0.021510508,
0.026346808,
0.0020761725,
-0.017128019,
-0.0027017796,
-0.028473223,
-0.022871934,
-0.017724453,
0.015533206,
-0.01240193,
-0.014340339,
0.005828194,
0.015325751,
0.032596394,
-0.00025749565,
0.024531575,
0.032570463,
-0.004223658,
-0.003653156,
0.025426226,
-0.019241467,
0.020421369,
-0.007507284,
0.0138217015,
0.049555857,
-0.0044538034,
-0.009348449,
0.016648278,
-0.00028322494,
0.023092354,
-0.014664488,
0.0077406713,
0.0343079,
0.0023857346,
-0.006833055,
0.035708223,
0.0031831404,
-0.008927056,
0.0018168535,
0.006236621,
0.0033079376,
0.017867077,
-0.02556885,
0.007844399,
0.0057244664,
0.020032391,
0.032051824,
0.0074813524,
0.010800635,
0.0035948092,
0.003406803,
0.042450517,
-0.017620724,
-0.0012301444,
0.031222004,
0.003653156,
0.013705008,
0.007896263,
0.0144311,
0.013050227,
0.026761718,
0.025944863,
0.014612624,
0.0064570424,
0.05616849,
0.034256037,
0.012615868,
0.0282917,
0.003526738,
0.012894636,
0.019461889,
-0.008395452,
-0.011390585,
0.023053456,
0.03088489,
0.026256045,
-0.044343542,
0.006220414,
-0.0065510455,
0.007915712,
-0.0047520204,
-0.0057990206,
-0.023572095,
-0.04551048,
-0.0060713054,
0.018009702,
-0.011215545,
0.025841136,
0.0099189505,
-0.013108574,
-0.022003215,
0.0023354916,
0.01222689,
-0.0115785925,
0.008998368,
0.006294968,
-0.053082593,
-0.0060162,
0.039727665,
-0.04278763,
0.007260931,
0.009692047,
-0.0066709807,
-0.02208101,
-0.019591548,
-0.025957828,
0.0045607723,
0.0030826542,
-0.00005581436,
-0.015948117,
0.006833055,
-0.013717974,
0.013795769,
-0.001769852,
0.037653115,
0.005727708,
-0.0052090697,
-0.01750403,
-0.012855738,
-0.007831433,
0.005802262,
0.001377632,
0.03620093,
-0.021510508,
0.012388964,
-0.004719605,
0.028032381,
0.01059318,
0.010119922,
-0.01885249,
-0.021873556,
-0.009750393,
0.026048591,
-0.013510519,
-0.007844399,
0.0000832657,
0.0007763362,
-0.0008363037,
0.031066412,
-0.011909224,
-0.01824309,
-0.018217158,
-0.0038087475,
0.03664177,
0.0036045336,
-0.020927042,
-0.00096677354,
-0.015675832,
-0.008382486,
-0.003191244,
-0.012797391,
0.0034586668,
-0.0063403486,
0.0073581757,
-0.0029124762,
-0.0022155566,
-0.015286854,
-0.0106061455,
-0.007811984,
-0.031896234,
-0.027824925,
-0.01113775,
-0.018385716,
0.005902748,
-0.01469042,
0.008635322,
-0.014781182,
-0.0023662855,
-0.017646655,
-0.012888153,
0.00745542,
-0.023818448,
-0.002888165,
0.007338727,
0.032492667,
0.018191226,
0.010690425,
0.018670967,
0.0039384067,
0.022314398,
-0.021873556,
0.011604524,
-0.033841126,
0.025542919,
0.013160438,
-0.025011314,
0.018100465,
-0.0008857364,
-0.012745528,
0.029458635,
0.028136108,
-0.022962695,
0.017659621,
-0.010612629,
0.02090111,
0.0052252775,
-0.013886531,
-0.00379254,
0.010515384,
0.023403537,
-0.002401942,
0.02790272,
-0.019850867,
-0.0088427765,
0.00795461,
-0.009769842,
-0.00673581,
-0.010943261,
-0.009763359,
-0.02125119,
-0.01070339,
-0.0026142595,
-0.008615873,
-0.0032139346,
-0.014807113,
0.015753627,
0.003520255,
0.0072479653,
-0.007993507,
-0.03474874,
-0.010411656,
0.007085891,
0.020123152,
-0.013205819,
-0.00073095533,
0.00276823,
0.011423001,
-0.011371137,
0.03485247,
0.0047422955,
0.02617825,
0.017400304,
0.019345196,
-0.00032820058,
0.00006650113,
-0.018424613,
0.01635006,
0.010904362,
0.007526733,
0.016324129,
0.019980527,
0.022962695,
0.00022183928,
-0.019539684,
0.0036174997,
-0.012726079,
-0.003311179,
0.01035331,
0.0113841025,
0.0034683913,
0.039001573,
0.009471625,
-0.011721217,
-0.016427856,
0.007883296,
0.034100443,
0.019461889,
-0.000027324724,
-0.020538062,
-0.008142616,
-0.007928678,
-0.0012941638,
0.009017818,
-0.031403527,
0.018087499,
-0.0006000803,
0.0403241,
0.014223645,
0.0052609337,
0.0046061534,
0.008440833,
-0.035915677,
0.04128358,
0.0036563976,
-0.025102077,
-0.00076215464,
-0.007935161,
-0.00865477,
-0.0051085837,
-0.0061166864,
0.016155573,
0.0034100446,
0.012726079,
-0.019578582,
-0.0145088965,
0.01028848,
0.0056142556,
-0.018230123,
0.020071289,
0.0036174997,
0.013575348,
-0.0074878354,
-0.0066969125,
-0.013549416,
0.024440814,
0.028991861,
0.002427874,
0.0028784405,
0.0032917303,
-0.0138217015,
-0.0066839466,
-0.002933546,
-0.009173409,
-0.031377595,
-0.004158828,
0.012084264,
0.01817826,
-0.0041555865,
0.03404858,
-0.0061166864,
-0.01715395,
-0.032440804,
-0.0077277054,
-0.010275514,
0.028836269,
0.03321876,
0.006482974,
0.009730944,
-0.0058930237,
0.0063046925,
-0.002541326,
-0.023935141,
0.009335483,
-0.023468368,
0.0081620645,
-0.00782495,
-0.0024700132,
-0.00673581,
0.009737427,
0.016077776,
0.0009019438,
-0.03620093,
-0.01174715,
-0.015468377,
-0.009886536,
-0.0007066442,
0.016842768,
0.033322487,
0.014962705,
-0.002105346,
-0.017581826,
0.017011324,
0.00032657984,
-0.009860604,
0.0020826554,
0.028058313,
-0.00074149016,
0.00081482885,
-0.017750384,
-0.024531575,
-0.00022528335,
-0.022106942,
0.024816826,
0.006440835,
0.010061576,
0.019721208,
0.022158805,
0.010385725,
-0.017776316,
-0.03114421,
-0.01968231,
-0.011539694,
-0.0048460234,
-0.015857356,
0.008732567,
-0.02547809,
-0.019695276,
-0.016972426,
0.018385716,
-0.00348784,
0.029277112,
-0.010755254,
-0.0043306267,
-0.011520245,
-0.0079610925,
-0.023740651,
0.014093986,
-0.018307919,
-0.005157206,
-0.011721217,
0.005996751,
-0.001431927,
0.0069238166,
-0.0014311166,
-0.010379242,
-0.017944872,
-0.031481322,
0.02051213,
0.0072285165,
0.023416502,
0.02009722,
-0.0071636867,
-0.003097241,
0.01251214,
-0.0004793349,
-0.013549416,
-0.0032657983,
-0.021990249,
0.009847638,
-0.016635312,
-0.0072414824,
-0.019799003,
-0.0054327324,
0.003899509,
0.017296575,
-0.0017309542,
0.024985382,
-0.0008695289,
-0.006272278,
-0.0032755227,
0.017542928,
-0.0020016183,
0.0060777883,
0.007513767,
0.0042431066,
-0.023766583,
-0.008337105,
-0.03321876,
-0.021432713,
-0.0013768217,
0.026580194,
-0.009309551,
-0.015325751,
-0.008246344,
0.006820089,
-0.006833055,
-0.0051798965,
0.002534843,
0.027228491,
0.013251199,
0.016168538,
0.021017803,
0.01837275,
-0.013873565,
0.000078048935,
-0.0060842712,
0.034489423,
-0.00847973,
-0.009270653,
0.020136118,
0.027773062,
-0.01887842,
-0.029977273,
-0.00018192847,
0.00079416437,
0.046392165,
0.0037504006,
-0.02243109,
-0.023455402,
-0.0039221994,
-0.0075980457,
-0.0009935158,
-0.008518628,
-0.01083305,
-0.02966609,
0.013964327,
0.021873556,
-0.005043754,
0.022923797,
-0.037549388,
-0.0059578535,
0.01894325,
-0.0007921384,
0.0063986955,
-0.019189604,
0.0064926986,
-0.018891387,
-0.0028606125,
-0.016324129,
-0.052978866,
-0.015857356,
-0.03212962,
0.024972416,
0.022768205,
0.027513742,
-0.0076758415,
0.013692042,
0.016324129,
0.0015008085,
0.012758493,
-0.009828189,
0.03034032,
-0.02992541,
0.011293341,
0.026761718,
0.0021880039,
0.036434315,
-0.019928662,
0.020719586,
-0.002667744,
-0.018307919,
0.014327373,
0.011144233,
-0.03827548,
-0.025594782,
0.02262558,
-0.013977293,
0.007766603,
-0.037782773,
-0.01240193,
0.030314388,
-0.00015994713,
0.0046353266,
0.012570487,
0.00860939,
-0.018398682,
0.02364989,
-0.027124764,
0.0064181443,
0.0106969075,
-0.022042112,
0.0056369463,
-0.028213903,
0.032311145,
0.000024754325,
0.0174781,
-0.004171794,
-0.013653144,
-0.005974061,
-0.0015478102,
-0.012732562,
-0.03949428,
0.0015615864,
-0.015870322,
-0.012427862,
-0.012427862,
-0.03651211,
-0.034541287,
-0.01065801,
0.002489462,
-0.032622326,
0.012246339,
-0.008006473,
-0.008414901,
0.025607748,
0.0156499,
0.0408946,
-0.011468382,
0.02016205,
0.008265792,
-0.0040551005,
-0.01408102,
0.0071377545,
0.0039481316,
0.0023046974,
0.04073901,
0.013393825,
-0.004677466,
-0.021095598,
0.00074594724,
0.007014578,
-0.013419757,
-0.010625595,
0.020875176,
0.017426236,
-0.013756871,
0.0008205014,
0.0035818433,
-0.03443756,
0.004810367,
0.004285246,
0.014846011,
-0.004764986,
-0.0162593,
-0.0121685425,
0.017957838,
0.0016474859,
0.027176628,
-0.004038893,
-0.0074424543,
-0.013977293,
0.002445702,
-0.011662871,
0.0074619036,
-0.007922195,
0.04592539,
-0.005575358,
0.0074878354,
0.022366261,
-0.0026969174,
-0.011111818,
-0.009082647,
0.0018346817,
0.040920533,
0.0068849185,
-0.008006473,
0.03215555,
-0.005873575,
0.0016474859,
-0.01590922,
0.0012836289,
-0.01645379,
-0.033011306,
-0.01144245,
0.012136128,
0.01205185,
-0.01776335,
0.022495922,
-0.02652833,
-0.018748762,
-0.022223637,
-0.022858968,
0.023948107,
-0.0378865,
-0.02077145,
-0.0117730815,
0.027228491,
0.027098833,
-0.0021085874,
-0.004917336,
0.0044084224,
0.034333833,
-0.022469988,
0.017387336,
0.010379242,
0.0025251184,
-0.013380859,
-0.0041199303,
-0.017011324,
-0.026217148,
-0.006554287,
-0.025542919,
-0.026307909,
0.009666115,
-0.005575358,
0.023079388,
-0.0003531195,
-0.030703366,
0.010982159,
-0.010761737,
0.017192848,
0.0072285165,
0.014651522,
0.014573726,
-0.017529963,
0.00860939,
0.014482965,
-0.006048615,
-0.016155573,
0.0011458657,
-0.017244712,
-0.007293346,
-0.00020472017,
-0.0010883294,
-0.03142946,
0.0026774684,
-0.02591893,
-0.022923797,
-0.004437596,
-0.015753627,
-0.014612624,
0.003572119,
0.008946504,
-0.012175025,
-0.009316034,
0.025750374,
-0.0032641776,
0.01606481,
-0.017465133,
0.00012895041,
-0.0066839466,
-0.0103079295,
-0.006453801,
-0.0119675705,
-0.0128427725,
0.02556885,
-0.0055137696,
0.014975671,
-0.00066572044,
-0.012187991,
-0.059020996,
-0.03596754,
0.0039286823,
0.017089121,
-0.0058865407,
-0.01126741,
-0.009672598,
0.006774708,
-0.005588324,
0.017957838,
-0.0021183118,
0.00038938364,
0.013367893,
0.0064862156,
0.024764962,
0.0038022643,
-0.024168529,
-0.032985374,
0.027228491,
-0.016466755,
-0.016713107,
0.01360128,
-0.011669354,
0.02339057,
-0.008330622,
-0.0028460256,
0.011623973,
-0.0013768217,
0.019500786,
-0.03324469,
0.006576977,
0.001876821,
0.0037374347,
-0.022962695,
0.009452176,
-0.006460284,
0.0027147455,
-0.0066580144,
0.004304695,
0.00024250375,
0.0020972423,
-0.009529972,
0.024946485,
0.008265792,
0.0055461847,
0.022871934,
0.014521862,
0.0066904295,
0.0052933483,
-0.008829811,
0.0032528325,
-0.00026823307,
0.017140985,
-0.0013873565,
-0.024972416,
-0.0004716364,
-0.013017813,
-0.014755249,
-0.0030826542,
0.013886531,
0.0027358152,
-0.008758498,
-0.012116679,
0.00019479312,
0.0025704992,
-0.0014416514,
0.0050923764,
-0.020952974,
-0.023157185,
-0.0023144218,
-0.0060129585,
-0.012194474,
-0.023961073,
0.013549416,
0.0034489422,
-0.0010551041,
0.0037471591,
-0.008758498,
-0.014469999,
0.028239837,
0.18505003,
-0.015066432,
0.0009448935,
0.009270653,
0.007319278,
0.00038857327,
0.021834657,
-0.0038638527,
-0.010035644,
0.0033484562,
0.0049821655,
0.009367898,
-0.013873565,
-0.004871955,
0.01894325,
-0.030858958,
-0.029199317,
0.010230133,
-0.009529972,
-0.020849245,
0.0046871905,
-0.020940008,
0.028317632,
-0.010411656,
0.022068044,
0.0036272241,
-0.03651211,
0.011526728,
0.033944853,
-0.004171794,
-0.018580204,
-0.0007613443,
-0.00025709046,
0.016233368,
0.009335483,
0.0037763326,
-0.015961083,
-0.018696899,
0.0029610984,
-0.0008099666,
0.007909229,
0.013225268,
-0.02432412,
0.005452181,
0.019824935,
0.02637274,
-0.024181494,
-0.005393835,
-0.011247961,
-0.015779559,
-0.058450498,
0.009050232,
0.009076164,
0.032492667,
-0.012466759,
-0.008278758,
0.003513772,
0.03104048,
0.0060713054,
-0.007902746,
-0.021510508,
0.006382488,
-0.0057666055,
0.003760125,
-0.023429468,
0.024933519,
-0.02842136,
-0.0007755258,
-0.010340344,
-0.0073581757,
0.0043954565,
-0.0057892962,
0.0028411634,
0.01179253,
-0.030651502,
-0.021769827,
0.017452167,
0.0088492595,
0.020927042,
0.021303054,
0.0032090722,
-0.0069108508,
-0.025128009,
0.003077792,
-0.015468377,
-0.031896234,
0.016025912,
-0.002090759,
-0.008136133,
-0.0030145831,
0.017516997,
-0.019513752,
-0.025789272,
0.011636939,
0.014807113,
-0.009147476,
-0.01715395,
-0.0014157195,
-0.0129464995,
-0.0044959425,
-0.034230106,
0.07623978,
0.020525096,
0.003520255,
-0.004777952,
0.002944891,
-0.010418139,
0.009102096,
-0.027410015,
-0.0063565564,
-0.0002990272,
-0.025361395,
0.009050232,
-0.007623978,
-0.016829802,
0.018217158,
0.029432703,
0.0018379232,
0.019760106,
-0.017011324,
-0.036719568,
-0.0050664446,
0.009329,
0.014353305,
-0.03705668,
0.015351683,
-0.009970815,
0.007863848,
-0.013199336,
-0.009147476,
-0.009445693,
-0.009899502,
0.0045834626,
-0.015286854,
0.018580204,
0.002166934,
0.0081620645,
-0.012544556,
0.0058703334,
0.025867067,
-0.008862226,
-0.0075396993,
-0.0055397013,
-0.001244731,
0.0067033954,
0.0059578535,
0.037082613,
0.0024683925,
-0.014858977,
-0.018450545,
-0.023766583,
-0.01096271,
-0.0020486198,
-0.012797391,
0.026398672,
-0.0015081019,
0.002693676,
-0.034178242,
0.010826567,
0.009108579,
-0.037523456,
0.011098852,
0.017140985,
-0.040272236,
-0.0047131223,
-0.0066904295,
-0.16160758,
0.009257687,
0.015688797,
-0.023027524,
0.023351673,
0.0049529923,
-0.009640182,
0.0048071253,
-0.012499174,
0.014171782,
0.04400643,
0.0025332223,
-0.02748781,
0.00046717934,
-0.005896265,
0.025115043,
-0.00016025102,
0.007338727,
0.010956227,
0.015247956,
0.03034032,
-0.02208101,
-0.0011758495,
-0.0062333797,
-0.0012042124,
0.004492701,
0.005316039,
-0.016622346,
-0.0037990229,
0.00174392,
-0.016324129,
0.0024068041,
0.037393797,
-0.0108978795,
0.012978914,
0.0018476477,
-0.0042884876,
-0.012440828,
-0.00003431418,
0.029562363,
0.024440814,
0.02186059,
-0.009834672,
0.009821706,
-0.0076628756,
0.028576951,
-0.00088411564,
-0.0073581757,
0.016466755,
0.009763359,
0.033011306,
-0.0026952967,
0.0021134496,
0.021756861,
0.018139362,
0.040272236,
-0.017737418,
0.020914076,
0.011656388,
-0.030444046,
0.009283619,
0.013212302,
0.01571473,
0.010625595,
0.004703398,
-0.027176628,
-0.0011085887,
0.0045186332,
-0.019021047,
0.007572114,
-0.03526738,
-0.03513772,
0.015468377,
-0.019643413,
0.03181844,
0.026269011,
-0.008901124,
0.019435957,
-0.0073646586,
0.008090752,
-0.02495945,
-0.0020081012,
-0.029562363,
-0.011818462,
-0.0074683866,
0.02576334,
0.02112153,
0.009030784,
-0.0127520105,
0.0074100397,
0.015338717,
-0.016466755,
0.017192848,
-0.0009967573,
0.023338707,
0.014729317,
0.012142611,
0.00082576886,
-0.014768216,
0.014042122,
0.023572095,
-0.013912463,
-0.006434352,
0.017257677,
0.0125510385,
-0.006061581,
-0.0056466707,
0.008661253,
0.04851858,
-0.017465133,
-0.025685545,
-0.015870322,
-0.0017974046,
0.0072479653,
-0.004884921,
0.019721208,
0.0044246297,
0.0034845986,
0.00044124745,
-0.0325186,
0.07209067,
0.009374381,
0.016220402,
0.041309513,
0.0004161259,
-0.03913123,
-0.13692042,
-0.023896243,
0.010333861,
0.024479711,
0.000042038035,
0.0030469978,
-0.018191226,
0.024246324,
0.014016191,
0.01395136,
-0.036460247,
-0.0038768186,
0.0028460256,
-0.008512145,
0.009115062,
-0.009504041,
0.006126411,
0.014223645,
-0.033322487,
0.044265747,
0.00082576886,
-0.0035818433,
-0.006042132,
0.0037374347,
0.0095234895,
0.0112868585,
-0.02371472,
0.0008002421,
-0.008460281,
0.00034521837,
0.008615873,
0.001680711,
0.025102077,
-0.0062917266,
-0.012291719,
-0.027824925,
0.023831414,
-0.02547809,
0.025374362,
-0.021497542,
0.0015891391,
0.007098857,
0.018450545,
-0.006664498,
-0.009679081,
-0.014249577,
-0.04564014,
0.02086221,
-0.0023030767,
-0.025880033,
-0.0355267,
-0.018385716,
-0.028810337,
-0.016168538,
0.031196073,
-0.0025251184,
-0.0086482875,
0.018995116,
-0.025361395,
-0.005880058,
-0.005555909,
-0.011656388,
-0.017387336,
0.01517016,
0.008025922,
-0.010709873,
-0.009082647,
-0.03744566,
0.025970794,
-0.010547799,
-0.0031847612,
-0.0074165226,
-0.0112803755,
0.0003448132,
-0.0240648,
0.015857356,
0.00812965,
-0.014106952,
-0.0018249573,
-0.019539684,
-0.014833045,
-0.029225249,
0.011727701,
-0.009128028,
0.0058314353,
0.0063792467,
0.006781191,
-0.0054132836,
0.011993502,
-0.002925442,
-0.006388971,
0.029303044,
0.006288485,
-0.00097568764,
0.00348784,
0.0075396993,
0.0043533174,
-0.007578597,
0.017672587,
0.0004999994,
-0.00577633,
-0.010677459,
-0.047247916,
0.017931907,
-0.0011677458,
0.025166906,
0.014768216,
-0.00028059122,
-0.0012390584,
-0.004803884,
0.0053679026,
0.016661244,
-0.016025912,
-0.00007744115,
0.0005806314,
-0.0222755,
-0.03863853,
-0.0113841025,
0.030988617,
0.0055591506,
0.014716351,
0.03718634,
0.010119922,
0.012784425,
-0.015559139,
0.013847633,
0.0014513759,
-0.005423008,
-0.008901124,
0.0039902707,
-0.009944882,
-0.014068054,
0.008557526,
-0.02547809,
-0.016648278,
-0.0009165305,
-0.0005397076,
-0.016570482,
-0.017244712,
0.04522523,
0.01990273,
0.019254433,
-0.017050222,
-0.007565631,
0.016972426,
0.0012585074,
0.020991871,
-0.0014651521,
-0.033166897,
-0.01469042,
-0.009692047,
-0.010165304,
0.018139362,
0.012388964,
-0.01756886,
-0.004726088,
-0.011228511,
-0.0034165275,
0.0018752003,
-0.011260927,
-0.012492691,
-0.024881655,
0.01974714,
0.02364989,
-0.019786038,
-0.0013233371,
0.0097244615,
-0.0054554227,
-0.021679066,
0.01414585,
0.020382471,
-0.023948107,
-0.035474837,
-0.017063187,
0.007753637,
0.009536455,
0.009730944,
0.012596419,
-0.008525111,
0.003141001,
-0.022223637,
0.033944853,
0.020408403,
-0.010690425,
-0.018930284,
0.010100474,
0.015701763,
-0.0019481338,
0.008764981,
0.006904368,
0.005111825,
-0.01222689,
-0.028758474,
0.005974061,
0.008687185,
0.010489453,
-0.0016628829,
0.05012636,
0.007014578,
0.024687165,
-0.006774708,
0.036434315,
0.00388006,
0.0014659626,
0.01612964,
-0.012901119,
-0.009970815,
0.027824925,
-0.017491065,
-0.043773044,
-0.023377605,
-0.0012123162,
-0.005828194,
0.016246334,
0.00023824931,
-0.0071312715,
0.0048168497,
0.007850882,
-0.025192838,
-0.0022269017,
-0.0057017757,
0.036538042,
0.011786047,
0.0053452123,
-0.0041264133,
-0.005393835,
0.0028346805,
0.0077082566,
0.02399997,
-0.027228491,
0.007098857,
-0.0023030767,
0.016985392,
0.0044278717,
-0.026709855,
-0.010638561,
-0.00049230084,
-0.021030769,
-0.0047066393,
0.025491055,
-0.010923811,
0.07411336,
-0.0021037252,
-0.027876789,
0.0032706605,
-0.032077756,
0.026735786,
-0.0077147395,
0.030314388,
-0.034359764,
-0.03513772,
0.02057696,
-0.008777947,
0.0015818457,
-0.037653115,
-0.013290097,
0.015299819,
-0.007533216,
0.015494308,
-0.005555909,
0.0045283576,
-0.00044043706,
-0.025322497,
0.002319284,
0.011040505,
-0.030081,
0.005555909,
0.047870282,
0.0034781157,
0.004463528,
-0.02502428,
0.0046353266,
0.01161749,
-0.03474874,
-0.0005113446,
0.014884909,
-0.019837901,
-0.018139362,
-0.031014549,
0.016077776,
0.007332244,
0.0007581028,
0.010489453,
-0.011390585,
-0.03212962,
-0.0043727662,
-0.023870312,
-0.0252836,
0.006612634,
-0.03376333
] |
Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid hormone and their structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. This discovery sparked identification of numerous genes encoding related proteins, termed orphan receptors. Characterization of these orphan receptors and, in particular, of the retinoid X receptor (RXR) positioned nuclear receptors at the epicenter of the "Big Bang" of molecular endocrinology. This Review provides a personal perspective on nuclear receptors and explores their integrated and coordinated signaling networks that are essential for multicellular life, highlighting the RXR heterodimer and its | [
-0.021597851,
-0.01703213,
-0.009621102,
-0.028823603,
-0.029644111,
0.020380326,
-0.0026616838,
0.0068684346,
-0.036472842,
-0.013068553,
0.014650013,
-0.008707957,
-0.004784083,
0.0045260205,
-0.023874097,
0.023675587,
0.031735078,
-0.008932935,
0.00044209757,
0.006673233,
-0.017429149,
0.012916363,
-0.0025640833,
-0.018726079,
0.0003291952,
0.012234813,
0.020843515,
-0.044042677,
-0.012975915,
-0.032026228,
-0.006673233,
0.02162432,
0.00033002233,
-0.015682263,
0.011612816,
0.0030256181,
0.0010471385,
-0.020420028,
0.013194276,
-0.009799761,
0.014120654,
0.00547225,
-0.012532577,
-0.009799761,
-0.0026616838,
0.01450444,
0.016793918,
-0.032264438,
-0.020274455,
0.0153249465,
0.004221639,
0.02112143,
-0.006709627,
-0.01962599,
-0.025276897,
0.007794813,
-0.0031960057,
0.0028684647,
-0.0008262965,
-0.0355994,
-0.007344858,
-0.0050950814,
-0.029802918,
0.014014782,
-0.016211623,
0.02757961,
0.004254724,
0.011434156,
-0.022233082,
0.008191832,
0.060294002,
0.018884886,
-0.015232309,
0.013750103,
0.0051314747,
-0.013723635,
-0.025753321,
-0.016185155,
0.009151296,
-0.010296035,
0.014451504,
-0.00087426964,
0.0012365498,
0.010348971,
-0.0020132188,
0.004896572,
0.0028353797,
0.015033799,
0.012698002,
-0.014398568,
0.022127211,
0.024932815,
0.013028851,
0.025673917,
-0.018090848,
0.011606199,
0.025766555,
0.0024532487,
-0.014358866,
-0.018752547,
-0.018554037,
0.02847952,
0.0022332338,
-0.007847749,
-0.017535022,
0.016648345,
-0.019943604,
-0.011923814,
0.020777345,
-0.0025690459,
-0.0047046794,
0.043433916,
0.0010487927,
-0.028664796,
0.046424795,
-0.023265334,
0.025157792,
-0.0095814,
0.001231587,
-0.009263785,
0.008807212,
0.022908015,
0.0050024437,
-0.0376639,
0.037002202,
0.0056972275,
-0.013194276,
-0.004046289,
0.0020760803,
0.0057203867,
0.006249746,
-0.010110759,
0.0029577941,
0.01859374,
-0.0041587777,
0.0042282557,
-0.0116459,
-0.003940417,
-0.0053498354,
-0.026785571,
0.01749532,
0.035705272,
-0.041369416,
0.00663684,
0.01450444,
0.021478746,
0.012777406,
0.017508553,
0.019242205,
0.008105812,
0.0029859163,
-0.0026368701,
0.031496868,
-0.010077674,
0.0034639938,
0.017548254,
-0.019003993,
0.01826289,
-0.00015580941,
0.0009147987,
0.019506883,
-0.011970133,
-0.0030206554,
-0.0025607748,
0.041025333,
0.014213292,
0.031179251,
0.00835064,
-0.0065938295,
0.012598747,
-0.010521012,
0.0054821754,
-0.017561488,
0.008694723,
-0.008714574,
0.009303486,
-0.00639532,
0.024138775,
-0.016952725,
0.019123098,
-0.028558925,
-0.013319999,
0.03536119,
0.0043341275,
-0.01670128,
0.013657466,
0.022749208,
-0.01610575,
0.0029081667,
-0.017058598,
-0.0026401787,
0.008820446,
0.0055417283,
-0.0038577046,
-0.63184303,
-0.0034242917,
0.0015756704,
-0.015351415,
0.0022530847,
0.024800474,
0.0027890608,
0.014888225,
-0.005948673,
0.016092516,
-0.023927031,
0.004089299,
0.009144679,
-0.032052696,
-0.03845794,
-0.031285122,
-0.02538277,
-0.017362978,
0.05322706,
0.008999105,
-0.008979254,
-0.0069015194,
-0.0074970485,
0.014213292,
0.010388672,
0.0053696865,
0.0044135316,
-0.020565601,
0.01540435,
0.03779624,
-0.031285122,
0.023013888,
-0.014226526,
0.005766706,
0.05386229,
-0.0026649924,
0.034408342,
0.027923694,
0.03872262,
0.043936808,
-0.02241836,
0.0129957665,
0.014755885,
0.007860983,
-0.036049355,
0.02019505,
0.016952725,
0.0144118015,
0.0022994035,
-0.0059453645,
0.004873412,
0.019506883,
0.0066897757,
-0.012214961,
0.0049362737,
-0.0061240233,
0.008476363,
-0.006994157,
0.01863344,
0.017323278,
-0.025263663,
0.026031235,
-0.005561579,
-0.0120892385,
0.0009958568,
0.00177997,
-0.029432368,
0.017389446,
-0.0029313262,
-0.008741043,
0.017958509,
0.040284228,
-0.0006832041,
0.01032912,
0.010501161,
0.03043815,
0.021677256,
0.014927927,
0.0018957673,
0.05153311,
0.0024598655,
-0.010640118,
-0.04041657,
0.0017187629,
0.03599642,
-0.01826289,
-0.008033024,
0.025726853,
0.0151926065,
-0.0023176004,
-0.013578061,
-0.015338181,
-0.015655795,
-0.034328938,
-0.032952607,
0.012962681,
-0.0013994932,
0.021981638,
-0.0057567805,
-0.027870758,
-0.01696596,
-0.02305359,
-0.0031745005,
-0.013214127,
0.003351505,
-0.016595408,
-0.014755885,
-0.0021141279,
0.033878982,
-0.044175018,
0.0017353053,
-0.012420088,
-0.0033829357,
0.017508553,
-0.0027129655,
-0.020472964,
0.01610575,
0.017759997,
-0.009065275,
-0.020300923,
0.021333173,
-0.01294283,
0.0023771534,
-0.023172695,
0.02026122,
0.003224128,
0.0013267063,
-0.024376987,
-0.009991653,
-0.0102761835,
0.017429149,
-0.010236482,
0.004932965,
-0.014610312,
0.019573053,
0.005485484,
0.02641502,
-0.016277792,
-0.01245979,
-0.04520727,
-0.022868313,
0.0130023835,
0.0021240534,
-0.009045424,
0.0033498507,
-0.0067724884,
-0.001813055,
0.0050950814,
-0.0050553796,
0.0044366913,
-0.0049461992,
0.007880834,
-0.018937822,
-0.0029859163,
0.0018080922,
-0.012261281,
-0.020552367,
-0.010355588,
-0.009594634,
0.022405125,
0.011103308,
0.021862531,
-0.030252874,
-0.006696393,
-0.018249655,
-0.022947717,
-0.008509448,
0.029564707,
0.017839402,
-0.03274086,
0.0036922798,
-0.018355528,
-0.03403779,
0.0102761835,
0.003679046,
0.016939491,
0.0091115935,
-0.012406854,
0.0030057672,
-0.016449835,
0.0037716837,
-0.01470295,
-0.02821484,
0.0024946048,
0.018315826,
0.0039040234,
0.029273558,
0.007847749,
0.013286914,
0.014094186,
-0.01936131,
0.027738418,
0.008575617,
0.04076065,
0.007159582,
-0.04129001,
0.032661457,
0.028426584,
-0.016780684,
0.022802144,
0.014636779,
-0.033561368,
0.02744727,
-0.015854305,
0.00010111586,
-0.0020529209,
0.0051612514,
-0.019771563,
-0.026454723,
-0.010309269,
0.007642622,
-0.009382891,
0.0063258414,
-0.0074242614,
-0.0020926227,
0.011791474,
-0.010084291,
0.018686377,
-0.019784797,
-0.023874097,
-0.009899016,
-0.011275349,
0.02072441,
0.0109246485,
-0.0023854245,
0.008165364,
0.0010645081,
-0.0074242614,
0.013134723,
0.00039681257,
-0.013750103,
0.009442443,
-0.018104082,
-0.00008519373,
-0.0016625185,
0.0015169447,
-0.0053167506,
-0.016873322,
0.010269566,
0.016714513,
0.009925484,
-0.002630253,
0.028161906,
0.021081727,
-0.013366317,
-0.010911414,
0.027367866,
0.00035814452,
-0.01527201,
-0.004046289,
0.010375438,
0.018567272,
-0.022735974,
0.009270402,
0.023979967,
0.0047675404,
0.018580506,
0.008767511,
0.04687475,
0.017323278,
0.010249716,
0.004135618,
-0.011235647,
-0.008661639,
0.017680595,
0.039384317,
0.008357257,
0.008271236,
-0.012843575,
0.0068353494,
-0.010262949,
-0.005819642,
0.006282831,
-0.011765006,
0.0042381813,
0.007808047,
0.008866766,
0.01259213,
0.019639224,
0.0037187478,
-0.016145453,
-0.010851862,
0.014001548,
0.034858298,
-0.010653352,
-0.013630997,
-0.038034454,
0.0003434631,
0.008760894,
0.0050553796,
0.014464738,
-0.016013114,
0.010454843,
-0.015761668,
-0.019917136,
-0.0057633976,
0.016860088,
-0.024244647,
-0.015311712,
0.0037022054,
0.03702867,
-0.016383665,
0.0060181515,
-0.0030603574,
0.015139671,
-0.007688941,
0.0029329804,
-0.031682145,
0.0018874961,
-0.016754216,
0.0054160054,
-0.007219135,
0.0063523096,
-0.016118985,
-0.0032290907,
-0.014530907,
-0.02542247,
0.024998983,
0.0074970485,
0.006038002,
0.0068684346,
-0.04428089,
-0.0058030994,
0.0026716092,
0.04361919,
0.0050289114,
-0.004678211,
0.025078388,
-0.006038002,
-0.01637043,
-0.012876661,
-0.016608642,
0.0073779426,
-0.010090908,
0.009852696,
0.018977525,
-0.0079536205,
0.0074573467,
0.011447391,
0.009852696,
-0.0015475483,
-0.025845958,
-0.005240655,
-0.012704619,
-0.0056608343,
-0.0050686137,
0.006133949,
0.03885496,
0.02026122,
-0.035678804,
0.012367153,
0.02335797,
0.0030669745,
-0.0314704,
0.009184381,
0.017111534,
-0.0017716988,
0.012817107,
-0.004916423,
-0.034540683,
-0.0014697986,
-0.0016798881,
0.0075168996,
-0.010342354,
0.021253768,
0.0036658118,
0.020102412,
-0.015549924,
-0.018620206,
-0.003339925,
0.003794843,
-0.0049825925,
-0.016979193,
-0.0064085536,
0.006038002,
-0.014848523,
0.0007915573,
-0.010071057,
-0.024601964,
0.00057981367,
0.007761728,
-0.014200058,
-0.019956838,
-0.008258002,
0.0012845229,
-0.015920475,
0.0047543067,
-0.014385334,
-0.00092555134,
0.0008461475,
0.0062662885,
-0.023437375,
-0.011983367,
-0.0026616838,
0.011387838,
-0.01955982,
-0.0267194,
0.0030686287,
0.046160113,
-0.0032638297,
0.003078554,
0.00008689967,
0.022683037,
0.026269445,
-0.020605303,
-0.0019784798,
-0.0008068591,
-0.020843515,
-0.0008486288,
-0.015986646,
0.009700506,
-0.021372873,
-0.0028138745,
0.026375318,
0.024125542,
-0.02096262,
0.023119759,
-0.0031960057,
-0.0053895377,
0.02661353,
0.019123098,
0.031682145,
0.00050495897,
-0.030067598,
-0.026454723,
0.00013533811,
-0.0026931146,
-0.01646307,
-0.015086735,
-0.004889955,
0.00639532,
0.025541577,
-0.030914573,
-0.01019678,
0.009846079,
-0.0145441415,
0.0034772276,
0.009157913,
-0.01859374,
0.0112952,
-0.0024135467,
0.031549804,
0.004023129,
-0.016913023,
0.004612041,
-0.0039768103,
0.01689979,
0.028770668,
-0.03131159,
0.014874991,
-0.00399997,
-0.010653352,
0.0024846795,
-0.009270402,
-0.004254724,
0.03197329,
-0.0048535615,
-0.03366724,
-0.015232309,
0.018911354,
-0.025806258,
-0.019242205,
0.0068485835,
-0.029432368,
0.004489627,
0.0056244405,
0.01766736,
-0.015708731,
0.0034871532,
-0.044386763,
0.005935439,
0.01423976,
-0.009753441,
0.009310103,
-0.0049594333,
0.007966855,
-0.023596182,
-0.023265334,
-0.021505214,
-0.047060024,
-0.008535916,
-0.019003993,
0.010084291,
0.03350843,
0.03260852,
-0.007358092,
0.010176929,
0.024297584,
0.010951117,
0.00815213,
0.013346466,
0.009607868,
-0.041131202,
0.0066467654,
-0.004029746,
-0.02076411,
-0.004612041,
-0.015549924,
0.007636005,
0.0028750817,
0.0027179283,
-0.007966855,
-0.00018755028,
-0.03589055,
-0.03366724,
0.010712905,
-0.006726169,
0.007993323,
-0.005806408,
0.0013324962,
0.030411681,
0.007106646,
0.012638449,
-0.028691264,
0.024244647,
-0.019956838,
0.028294245,
-0.006236512,
0.00056699326,
-0.0133795515,
0.00007707758,
-0.0074639637,
-0.017045364,
0.021544917,
0.0035400891,
0.029035347,
0.023172695,
0.007715409,
0.03199976,
-0.010977585,
0.0066269143,
0.007894068,
0.00386763,
-0.001907347,
-0.008449895,
-0.008926318,
-0.016952725,
-0.051427238,
-0.019242205,
0.01962599,
-0.008377108,
0.021081727,
-0.0095814,
-0.020645006,
0.033032008,
-0.0095086135,
0.027261995,
-0.025237195,
0.019850967,
0.010018121,
0.0034739191,
-0.028532457,
-0.026745869,
0.0049892096,
0.0056839935,
0.053915225,
0.009528464,
0.0037319819,
-0.0038113857,
0.0069213705,
0.00417532,
-0.035519995,
-0.04232226,
0.0086020855,
-0.013750103,
-0.002034724,
0.006289448,
-0.015576392,
-0.00964757,
0.0021290162,
-0.013869209,
-0.0078676,
-0.0055251857,
-0.012698002,
-0.035122976,
0.029591175,
-0.019811265,
0.012069387,
-0.006603755,
-0.022391891,
-0.005968524,
-0.032714393,
0.0013142994,
-0.010309269,
-0.00903219,
0.03599642,
0.004588882,
0.007722026,
0.015867539,
0.0011951936,
0.010084291,
-0.022378657,
-0.019176034,
0.041792903,
-0.005372995,
-0.010600416,
0.020578835,
-0.005253889,
-0.0008486288,
0.002401967,
-0.00705371,
0.012142175,
-0.018421696,
0.001405283,
0.014689716,
0.0049131145,
-0.0077286432,
0.004148852,
-0.026388552,
0.008787361,
-0.040972397,
-0.0124862585,
0.005925514,
-0.030120533,
0.0005099217,
0.004496244,
0.009806378,
0.028797137,
0.0073316237,
-0.0033118029,
-0.0006290275,
0.025528343,
-0.013816273,
0.0140280165,
0.017138,
0.0019834423,
-0.04353979,
0.0017849328,
-0.024893112,
-0.031523336,
0.015655795,
-0.024496093,
-0.030967508,
-0.0074507296,
-0.0015748434,
0.011447391,
0.02059207,
-0.009310103,
0.023993202,
0.0018709536,
0.016291026,
0.0014044559,
-0.024138775,
0.015126437,
-0.0055781216,
0.024946049,
-0.012228196,
0.00071752974,
-0.0016451488,
-0.0030322352,
-0.011387838,
-0.0024648283,
0.007808047,
0.007629388,
-0.021544917,
0.030835168,
0.0005264642,
0.0069743064,
-0.026335616,
-0.0157352,
-0.022074275,
0.034620088,
0.017164469,
-0.019811265,
-0.014742651,
0.01450444,
0.012922979,
0.009131445,
-0.006090938,
-0.0087344255,
0.00916453,
-0.0007526825,
-0.038034454,
0.0067956476,
-0.017151235,
0.030649893,
0.017958509,
-0.02608417,
-0.0034772276,
-0.022934483,
-0.0170983,
-0.029458834,
-0.0032936062,
0.014888225,
-0.0038047687,
0.0032257822,
0.006478032,
0.007649239,
0.00078990305,
0.02012888,
-0.008363874,
-0.0444397,
0.0143721,
-0.0066599995,
0.04195171,
0.017918807,
-0.030993976,
-0.001819672,
0.03575821,
-0.028664796,
-0.018183485,
0.011771623,
-0.02558128,
0.03705514,
-0.024734305,
-0.003052086,
0.003138107,
0.01813055,
0.024681369,
-0.020062711,
0.0013498657,
0.023000654,
0.0002586829,
-0.019414246,
0.0066930843,
0.0020032935,
0.025819492,
0.0287442,
-0.025501875,
-0.014014782,
0.019176034,
0.010137227,
0.031576272,
0.016251326,
-0.0031000592,
0.0065045003,
0.0095086135,
-0.007993323,
0.013134723,
-0.015549924,
-0.013842741,
0.018752547,
-0.0016757525,
-0.0017965125,
0.0034309088,
-0.0069809235,
-0.01869961,
-0.012135558,
0.021333173,
0.0018709536,
-0.002302712,
-0.025462173,
0.0030173468,
0.0072654537,
0.00044995526,
-0.012360536,
-0.0065011918,
0.010395289,
-0.016793918,
-0.013458955,
0.0075102826,
-0.0069081364,
-0.007993323,
-0.0031943514,
-0.00068733975,
-0.008496214,
-0.00035008008,
-0.03043815,
-0.00929687,
0.013617763,
0.18527569,
-0.022537464,
-0.000448301,
0.023834394,
0.0035136212,
-0.008390342,
0.019136332,
-0.00903219,
-0.009230699,
0.02951177,
0.019268671,
0.023516778,
-0.0124796415,
-0.00048883003,
0.015576392,
-0.014332398,
-0.030279342,
0.010937883,
-0.01630426,
0.0033912067,
0.010104142,
0.0060876296,
0.0034176747,
-0.022603635,
0.06717567,
0.022365423,
-0.034249533,
0.0030884796,
-0.0011530103,
0.005981758,
-0.018779015,
-0.021716958,
0.012340684,
0.002481371,
0.0138956765,
-0.010249716,
-0.000012897959,
0.0052902824,
0.0045921905,
0.02485341,
-0.014173591,
0.0198245,
0.0064350218,
-0.015338181,
0.027950162,
-0.0060115345,
0.0058527268,
-0.024800474,
-0.015496988,
0.000024361376,
-0.032317374,
0.0051546344,
0.004972667,
0.01081216,
-0.001344903,
-0.012896512,
0.01740268,
0.017574722,
-0.008165364,
0.025647448,
-0.025859192,
0.010633501,
-0.035096508,
-0.0014673173,
-0.0037716837,
0.039410785,
-0.012036303,
0.009859313,
0.028056033,
-0.019321607,
-0.00711988,
0.02914122,
-0.014252994,
0.0034441426,
0.0014325781,
-0.0118377935,
0.011592965,
0.024522562,
0.035811145,
0.018712845,
-0.017839402,
0.021862531,
-0.022193382,
0.01740268,
-0.017124766,
-0.023940265,
0.036208164,
0.0049296566,
-0.016555706,
0.020036243,
0.009601251,
-0.0031199104,
-0.017349744,
-0.02116113,
-0.008046258,
-0.018381996,
-0.008608703,
0.020896452,
-0.012049537,
0.0044863187,
-0.0074970485,
0.063470155,
0.011348136,
0.012360536,
-0.019599522,
0.006256363,
-0.0027261993,
0.019123098,
0.0033796271,
-0.011579731,
0.015298478,
-0.012049537,
0.006150491,
0.006388703,
-0.014914693,
0.016740981,
0.015642561,
-0.040866524,
0.018024677,
-0.010580565,
-0.013028851,
-0.030861637,
-0.0029065125,
0.013723635,
-0.0021670638,
-0.006577287,
-0.012750938,
-0.014213292,
0.011143009,
-0.032449715,
-0.009091742,
-0.005574813,
0.015576392,
0.019308373,
0.007139731,
-0.027685482,
0.02784429,
-0.014689716,
-0.005994992,
0.031364527,
-0.013114872,
0.0065872124,
0.042401664,
0.034620088,
-0.0014640088,
-0.02887654,
0.011275349,
0.009945334,
0.00676918,
0.02588566,
-0.015417584,
0.0047046794,
-0.006180268,
-0.017124766,
0.012433322,
-0.025012217,
-0.023463843,
-0.046795346,
0.017984975,
-0.0014573918,
-0.01107684,
-0.0010521013,
0.011526795,
-0.019837733,
-0.01547052,
0.020075945,
-0.16621876,
0.023331502,
0.04017836,
-0.046027776,
0.011401072,
0.013022235,
0.0035566315,
0.010732756,
-0.0034772276,
-0.0082116835,
0.017190937,
-0.007351475,
-0.036181696,
-0.048304018,
0.005961907,
0.0033349625,
-0.005293591,
0.026401786,
0.0074970485,
0.00270304,
0.030279342,
-0.012698002,
0.021280237,
-0.02408584,
-0.0029048582,
0.004744381,
0.0066533824,
-0.0037584498,
0.01859374,
0.0040926076,
-0.0065111173,
0.007179433,
0.012539194,
-0.002876736,
0.020750877,
0.006375469,
0.008661639,
0.012148792,
-0.0060313856,
-0.006229895,
0.008999105,
0.015219075,
0.014425036,
0.00991225,
-0.015444052,
0.011381221,
-0.011970133,
0.0024350518,
0.009065275,
-0.016860088,
0.0045789564,
-0.009793144,
0.009091742,
0.016714513,
0.045736626,
-0.006448256,
-0.0042447983,
0.043804467,
0.014094186,
-0.0056773764,
-0.022484528,
-0.011870878,
0.01786587,
-0.016317494,
0.014080953,
-0.004979284,
-0.02687821,
-0.035414126,
-0.05322706,
-0.0028552308,
-0.018712845,
-0.016079282,
0.008390342,
-0.017640892,
0.025528343,
0.023212397,
-0.018514335,
-0.00085690006,
0.0040198206,
-0.005574813,
0.012135558,
-0.012625215,
-0.013167808,
-0.010507778,
-0.013855975,
0.021399342,
0.015946943,
0.016621877,
0.006061162,
0.012830341,
0.022841847,
-0.033032008,
-0.007722026,
-0.010223248,
0.018739313,
0.013604529,
0.006507809,
-0.0049064974,
0.00020016392,
-0.010554098,
0.024204945,
-0.0053167506,
0.017627658,
0.0022001488,
0.029961726,
-0.022960952,
-0.015946943,
0.0002144318,
0.033587836,
-0.011989984,
0.009812995,
-0.0133795515,
-0.014477972,
0.013816273,
-0.0042447983,
0.016039582,
-0.008244768,
0.0122215785,
0.019070162,
-0.018646674,
0.05939409,
0.029167688,
-0.004469776,
0.010693054,
0.0022249625,
-0.025435705,
-0.11095367,
-0.023596182,
0.024231413,
-0.004433383,
-0.016979193,
0.02309329,
0.011156243,
0.015311712,
-0.004628584,
0.016582174,
-0.023318268,
-0.0056244405,
-0.0057799397,
-0.013789805,
0.008522682,
-0.0053299847,
0.0107923085,
-0.022008106,
-0.030782232,
0.030570488,
0.0059188968,
-0.032423247,
-0.0039834273,
0.008588851,
0.014597078,
0.001839523,
-0.027341397,
0.0009627719,
0.0014334052,
-0.0022166914,
-0.010157078,
-0.000078886915,
0.015245543,
-0.017204171,
-0.026957612,
-0.030147001,
-0.016608642,
-0.015682263,
0.029088283,
-0.005872578,
0.020499432,
0.019123098,
0.012367153,
0.0051314747,
-0.004784083,
-0.00037385986,
-0.021531682,
-0.009455677,
0.021253768,
0.026242979,
-0.029749982,
-0.016396899,
-0.032105632,
-0.008919701,
0.018249655,
-0.028294245,
-0.0062993737,
0.008178598,
-0.016595408,
0.006104172,
0.0253166,
0.024099074,
-0.0024797167,
0.016423367,
0.0038113857,
-0.0143721,
-0.0038510875,
-0.028267777,
0.018315826,
-0.02861186,
-0.009720357,
0.013333233,
0.009554932,
-0.004694754,
-0.022802144,
0.016873322,
-0.030147001,
-0.009204231,
0.007298539,
-0.033429027,
-0.0060578533,
-0.020883217,
0.029273558,
0.007291922,
-0.006696393,
0.0102828005,
-0.0004396162,
-0.019665692,
-0.014782353,
-0.018580506,
-0.03160274,
0.014226526,
-0.0027989864,
-0.0068618176,
0.0012291058,
0.0039304914,
-0.001981788,
-0.0020380325,
0.021399342,
0.008853531,
-0.023119759,
-0.030596957,
-0.06241144,
0.0287442,
0.0062530544,
-0.008569,
0.020340623,
-0.03162921,
0.0026649924,
-0.0056244405,
0.014213292,
0.006104172,
-0.023305034,
0.026573827,
0.012168643,
-0.0052902824,
-0.026997315,
-0.039199043,
0.019109864,
-0.005300208,
0.018580506,
0.036472842,
0.009746824,
-0.0005922205,
0.05166545,
0.014583844,
-0.0074904314,
0.00582295,
-0.03237031,
0.011328285,
-0.008039641,
-0.0025690459,
0.0037319819,
-0.0445191,
-0.007351475,
0.019401012,
-0.006464798,
-0.009918867,
-0.013114872,
0.009402742,
0.01879225,
0.025131324,
-0.044466164,
-0.050686136,
-0.0014797242,
-0.0006104172,
-0.007808047,
-0.0037749922,
-0.033826046,
-0.00084407965,
-0.013095021,
-0.0012307599,
0.030729296,
0.019017227,
-0.016291026,
-0.017045364,
-0.011526795,
-0.003821311,
-0.019281905,
-0.016939491,
-0.02065824,
-0.011182711,
0.023000654,
0.031417463,
0.023384439,
-0.009561549,
0.0000016962496,
-0.029088283,
-0.036552247,
-0.012248047,
0.029670577,
-0.0066533824,
-0.042745747,
0.027023783,
0.01210909,
0.0170983,
-0.0027195825,
-0.025290132,
-0.040310696,
0.008721191,
-0.015483754,
0.012095856,
0.02215368,
0.018686377,
-0.016555706,
0.012651683,
0.015166138,
0.0029544856,
-0.012797257,
-0.0010661624,
-0.0021703723,
0.013816273,
-0.005412697,
0.028903008,
0.022100743,
0.020115646,
-0.0080859605,
0.024072606,
-0.0044466164,
0.008575617,
0.016092516,
0.017786466,
-0.0024714454,
0.0003517343,
0.015721966,
-0.02241836,
-0.0033945153,
0.02861186,
-0.013578061,
-0.038431473,
-0.027288463,
-0.0064747236,
-0.014941161,
-0.024204945,
0.009475528,
-0.0026997314,
-0.013095021,
-0.00896602,
0.016357196,
-0.0074374955,
-0.011553262,
-0.010507778,
0.032582052,
0.020023009,
-0.015774902,
0.009991653,
0.006478032,
-0.00399997,
0.03549353,
-0.023940265,
0.0287442,
-0.020499432,
-0.0011579731,
-0.005760089,
-0.015338181,
-0.0043639042,
-0.014014782,
-0.003814694,
-0.0040495973,
0.024244647,
-0.03004113,
0.072151646,
0.0051744855,
-0.019056927,
-0.0023506854,
-0.019665692,
0.03406426,
-0.0074374955,
0.011215797,
-0.048383422,
-0.0095086135,
0.017468851,
-0.023278568,
0.018143784,
-0.011460625,
-0.011917197,
0.01793204,
-0.0063622347,
-0.010203397,
0.0052505806,
-0.018157018,
0.0014044559,
-0.042772215,
0.008879999,
0.00026695416,
-0.031788014,
-0.0053994628,
0.038802024,
0.019811265,
0.016383665,
-0.008019791,
0.004843636,
-0.013842741,
-0.025978299,
0.008760894,
0.0047410727,
-0.004516095,
-0.01896429,
-0.0050189863,
0.009621102,
0.018779015,
0.010772458,
0.016793918,
-0.015351415,
-0.019599522,
0.007133114,
-0.0060512363,
-0.011712071,
-0.011639284,
-0.015099969
] |
Short interfering RNAs (siRNAs) have been used to inhibit HIV-1 replication. The durable inhibition of HIV-1 replication by RNA interference has been impeded, however, by a high mutation rate when viral sequences are targeted and by cytotoxicity when cellular genes are knocked down. To identify cellular proteins that contribute to HIV-1 replication that can be chronically silenced without significant cytotoxicity, we employed a shRNA library that targets 54,509 human transcripts. We used this library to select a comprehensive population of Jurkat T-cell clones, each expressing a single discrete shRNA. The Jurkat clones were then infected | [
-0.049140282,
-0.01040837,
-0.008704698,
-0.018074892,
0.014986987,
-0.0064120614,
-0.010907493,
0.0043124193,
-0.048075486,
-0.005267407,
0.0060260734,
-0.0017735489,
0.016690658,
0.00041947095,
-0.0036835247,
0.012970532,
0.02474317,
-0.02506261,
0.023332316,
-0.014827268,
-0.037933316,
0.0026187298,
-0.013329901,
-0.02672635,
-0.009130616,
0.013037082,
0.012837433,
-0.04589266,
-0.034073435,
-0.021908155,
0.005094378,
-0.0046651326,
-0.011965632,
-0.016184881,
-0.030426513,
-0.013203456,
0.0022360692,
-0.017369466,
0.014587689,
-0.009157236,
0.024423731,
0.019006588,
-0.00042841356,
0.018979969,
-0.00086597766,
0.008405224,
0.004462156,
0.020124622,
0.0007461883,
0.020843359,
0.019751944,
0.004764957,
-0.01682376,
0.0038066416,
-0.023358937,
-0.0024789756,
0.0046118926,
0.02691269,
-0.013988743,
-0.0034273085,
-0.0028416712,
0.0008218885,
-0.025794655,
0.012750918,
-0.0057964767,
0.023398867,
0.020337582,
-0.013057047,
-0.0010980697,
0.0164777,
0.017555805,
0.017289607,
-0.013376486,
0.012151971,
-0.0043556765,
-0.018274542,
-0.0166108,
0.0073271194,
0.010820977,
0.0023209201,
0.022174353,
-0.004874764,
-0.003843244,
0.0064553185,
0.024224082,
0.00018082795,
0.0041294075,
0.029920734,
0.0066649504,
0.0024856306,
0.019365957,
0.031784125,
0.0062390324,
0.023784855,
-0.03503175,
0.026473463,
-0.0006035224,
0.02885594,
-0.013829023,
-0.02086998,
-0.016144952,
-0.0019715342,
-0.015665794,
-0.007060921,
-0.019632155,
0.0001438097,
0.0060892957,
-0.004891401,
0.002766803,
-0.010554779,
-0.030639471,
0.009263715,
-0.0019881716,
-0.04477462,
0.04756971,
-0.009103996,
0.028323542,
-0.0049146935,
0.0017186454,
-0.025941065,
0.014561069,
0.00924375,
0.019805184,
-0.037134722,
0.031730887,
0.007673178,
-0.004305764,
-0.011812568,
-0.012185246,
-0.002573809,
0.021149488,
0.03167765,
0.0013659322,
0.014933748,
-0.011666158,
0.003249288,
-0.017010098,
-0.017249677,
-0.014947058,
-0.01454776,
0.0059096115,
0.026127404,
-0.0103152,
0.006372132,
0.007060921,
0.0013517904,
0.0043989336,
-0.0062490148,
0.00677143,
0.015745655,
-0.013077011,
-0.014774028,
0.013882263,
-0.01642446,
0.008198921,
0.013529549,
-0.013156871,
0.019259477,
-0.011286825,
-0.00815899,
0.00012623642,
-0.011825878,
0.028057344,
0.021043008,
0.015239877,
0.024490282,
-0.0072938446,
-0.0031627733,
-0.0011463182,
-0.010055657,
0.0032326507,
0.01448121,
-0.014188391,
0.014241631,
-0.015306426,
0.014108532,
0.004395606,
0.019632155,
0.0044122436,
-0.010135516,
-0.022400621,
0.012591199,
0.0115929535,
-0.0010348475,
-0.0066815875,
0.003959706,
0.012191901,
-0.0090973405,
-0.009663013,
-0.005982816,
-0.015013607,
-0.010727808,
0.018833559,
-0.025129158,
-0.6405806,
-0.03098553,
0.0070808856,
-0.0052274773,
0.017515875,
0.02298626,
0.02282654,
0.0018600635,
-0.0123116905,
0.03479217,
-0.015386285,
0.013136907,
0.02287978,
-0.036575705,
-0.032423005,
-0.047117174,
-0.015878754,
-0.0049612783,
0.014867198,
0.0021828294,
-0.021322517,
0.0032592705,
0.01633129,
0.02890918,
0.005516968,
-0.012371585,
0.021575406,
-0.028190443,
-0.011093832,
0.029414957,
-0.018780319,
0.030320033,
-0.019312717,
-0.004551998,
0.052760586,
-0.012797503,
0.0036203025,
0.035777107,
0.011566334,
0.008831142,
-0.012784193,
0.0032076945,
0.00670488,
0.01339645,
-0.0069211666,
0.00416601,
-0.02077681,
-0.0207635,
0.007912757,
-0.014827268,
0.009769493,
0.019685395,
-0.04128742,
-0.0030928962,
-0.0065019038,
-0.005756547,
0.027418468,
-0.019951593,
0.03953051,
0.019765254,
-0.0029365045,
0.016065093,
-0.0069411313,
-0.010714498,
-0.0023891334,
0.009616428,
-0.0093901595,
0.0005843894,
0.021482237,
0.010035692,
0.032130186,
0.028669601,
-0.006854617,
-0.0061558452,
0.00006498992,
0.0329554,
-0.011626229,
-0.009949177,
0.0041859746,
-0.00032027034,
0.009516604,
-0.012910637,
-0.044907723,
0.009969141,
-0.00050452974,
0.0056400853,
-0.025847895,
0.018367711,
-0.0064952485,
0.004608565,
0.0046451674,
0.0025704813,
0.006821342,
-0.026114093,
-0.026233884,
0.00722064,
-0.0062756347,
0.006372132,
-0.009356884,
-0.014121842,
-0.01336983,
-0.000638045,
-0.00726057,
-0.0019781892,
0.006415389,
-0.008518359,
-0.041873056,
0.014601,
0.037347678,
-0.04120756,
-0.0047882493,
-0.0042425417,
0.006112588,
-0.0043224017,
-0.006002781,
-0.029787635,
0.035377808,
0.01139996,
0.011000662,
-0.046212096,
-0.0020480664,
-0.015812203,
0.004448846,
-0.009489984,
-0.0062223948,
0.007426944,
-0.0012719308,
-0.0061625,
-0.010102241,
-0.01450783,
0.02685945,
-0.015199946,
0.018074892,
-0.0021096247,
0.016690658,
0.006422044,
0.0124714095,
0.017835313,
0.00037850128,
-0.01667735,
-0.025129158,
-0.015333046,
-0.0005344771,
-0.00064428407,
-0.00027118993,
-0.013183491,
0.0035604078,
-0.015093467,
0.018261231,
-0.017835313,
0.025195708,
-0.009503294,
0.01870046,
0.020949839,
0.012651093,
-0.013882263,
-0.032156803,
-0.034872033,
-0.0029414957,
-0.0056134653,
0.005550243,
0.0203642,
0.020271031,
0.004006291,
0.0039996356,
-0.015106777,
0.030852431,
0.003836589,
-0.012511339,
-0.042591795,
0.015399596,
-0.015093467,
-0.01855405,
0.015772274,
0.0046817698,
0.024410421,
-0.015173326,
0.018460881,
-0.011013972,
0.005107688,
0.004275817,
-0.011746018,
-0.02069695,
-0.0019615518,
0.016850378,
0.011785948,
0.022054562,
0.0025971013,
0.023212528,
0.036948383,
-0.0027368555,
-0.004395606,
-0.009277025,
0.013908883,
0.0004982907,
-0.008691388,
0.019232856,
0.015559315,
0.00937685,
0.02681952,
0.017316226,
-0.007001026,
0.004289127,
-0.030586231,
-0.006272307,
-0.02282654,
0.007646558,
-0.02257365,
0.016238121,
-0.003372405,
0.004545343,
0.015945302,
-0.013256696,
-0.0065850904,
-0.005034483,
0.00624236,
-0.012318346,
0.010674568,
-0.010128861,
-0.02293302,
-0.0047083898,
0.012491374,
0.020497302,
-0.017369466,
-0.010514849,
0.000005010723,
-0.005347267,
0.013077011,
-0.00027451743,
-0.0009882627,
-0.008525014,
-0.013389795,
0.008072476,
-0.009636394,
0.0032825628,
0.006854617,
-0.004345694,
-0.02496944,
0.033594277,
0.0058829915,
-0.029468197,
-0.00569998,
-0.0027867677,
-0.015053537,
0.017648974,
0.0049612783,
0.023518655,
0.016304672,
0.0042591793,
0.044401944,
-0.014175082,
0.01440135,
-0.027152268,
0.007573353,
0.015825514,
-0.014680859,
0.010255305,
0.02065702,
0.046291955,
0.015173326,
0.014827268,
-0.0044654836,
0.0058763367,
-0.019978214,
0.0043124193,
0.0039730156,
0.00827878,
0.0030579576,
-0.015133397,
0.01248472,
-0.014587689,
-0.008458464,
0.016810449,
-0.012145316,
0.013429725,
0.011659504,
0.008025891,
0.017436016,
0.031810746,
-0.0005211672,
-0.032076944,
-0.018021652,
0.021908155,
-0.010009072,
0.00046376805,
-0.02683283,
-0.028376782,
-0.0009641385,
-0.018833559,
0.002545525,
0.003616975,
0.016903618,
0.012591199,
0.012305035,
-0.0017619027,
-0.020031452,
0.0413939,
-0.014707479,
0.011187001,
-0.0059528686,
0.0077064526,
-0.010481575,
-0.0011804249,
-0.017276296,
0.02885594,
0.0046717874,
0.014601,
0.00029801778,
-0.008025891,
-0.0024207446,
0.0005590173,
-0.0024323908,
0.011473165,
-0.015825514,
0.008498394,
0.005956196,
-0.0118325325,
0.0027418467,
0.004618548,
0.010401715,
-0.016690658,
-0.046691254,
-0.012211866,
-0.018860178,
0.031863987,
0.018354401,
-0.009210476,
0.020883288,
0.000030285302,
0.020071384,
-0.00669157,
-0.029654536,
0.020444062,
-0.03135821,
-0.005550243,
-0.004688425,
-0.008864417,
0.0012303372,
0.011945667,
0.019472435,
0.009103996,
-0.024423731,
-0.018886799,
0.004705062,
0.021402376,
0.0051742373,
0.014281561,
0.03252948,
0.022214282,
-0.006112588,
0.024330562,
0.007500149,
0.004688425,
-0.0122850705,
0.018061582,
0.014228321,
-0.0123915505,
0.014228321,
0.0021994668,
-0.036309503,
0.021122867,
0.018381022,
0.0076931426,
0.0007045947,
0.026207263,
0.009024137,
0.001424995,
0.009689633,
0.011313445,
0.0103152,
0.0002984337,
0.017648974,
-0.03146469,
-0.015426216,
0.01655756,
-0.015040227,
-0.014654239,
-0.0043556765,
-0.0018018326,
0.025595006,
-0.005982816,
-0.0006334697,
-0.01134672,
-0.0073470846,
-0.015719034,
-0.008691388,
0.0008742964,
-0.0015572625,
-0.020004833,
-0.014960367,
0.005680015,
-0.0013567816,
-0.0040262556,
-0.027631426,
0.025887825,
-0.027059099,
-0.018247921,
0.02470324,
0.0064519914,
0.013962123,
0.012092076,
0.0015339701,
-0.0078062774,
0.016743898,
-0.007819587,
-0.024237392,
0.0059861434,
-0.037773598,
-0.001657087,
0.003992981,
-0.01035513,
-0.011306791,
-0.023012878,
-0.01027527,
0.0127376085,
0.011213621,
0.027791146,
0.0032526155,
-0.012145316,
0.009410124,
0.026020924,
0.029175378,
-0.0040329103,
-0.0083054,
-0.007859517,
-0.03729444,
0.01134672,
-0.017223056,
-0.021056319,
-0.035750486,
-0.0028699548,
0.013083667,
-0.018926729,
-0.019858424,
0.00929699,
-0.012937257,
0.0044521736,
0.0044555007,
0.023665065,
0.02701917,
-0.004881419,
0.0064253714,
0.00072247995,
0.0017336191,
-0.023598516,
-0.0058896467,
0.010361785,
0.009137271,
-0.008312055,
-0.0066682776,
-0.0015364657,
-0.029947355,
-0.018806938,
0.002681952,
-0.023345627,
0.04762295,
0.019152997,
-0.028563121,
-0.017995033,
-0.0077463826,
-0.00013070773,
-0.004751647,
0.017169816,
-0.020537231,
-0.0024124258,
-0.004931331,
0.0013767465,
-0.0009757847,
-0.0089110015,
-0.024516901,
-0.0029614607,
0.033913717,
0.019006588,
-0.016078401,
-0.002044739,
-0.004475466,
-0.03266258,
0.00010419184,
-0.00932361,
-0.016743898,
-0.0063554943,
0.004262507,
0.04102122,
0.018713769,
0.03127835,
-0.010528159,
-0.006711535,
0.026353672,
0.031438068,
-0.005217495,
0.02249379,
0.015426216,
-0.02096315,
0.020044763,
0.049859017,
-0.004492103,
-0.0020164552,
-0.030586231,
-0.00078902964,
-0.0061258976,
-0.01855405,
-0.022094494,
0.013569479,
-0.011952322,
-0.028776081,
0.010268616,
-0.012770883,
-0.007420289,
-0.026406912,
-0.0049878983,
0.023052808,
-0.004861454,
0.036921762,
-0.015279806,
0.017382776,
0.008558288,
0.005543588,
-0.010481575,
0.02065702,
-0.02268013,
0.009316955,
-0.0003192305,
0.009077376,
0.018713769,
-0.0014158444,
-0.0052574244,
0.006641658,
-0.026646491,
-0.00084060564,
0.007932722,
-0.025674867,
-0.015838824,
-0.008977552,
-0.00509105,
-0.015492765,
-0.0094433995,
-0.026340362,
-0.032103565,
-0.01839433,
0.010441644,
-0.012611164,
-0.0016903618,
-0.0035670628,
-0.013602754,
0.030160313,
-0.003487203,
0.027445087,
-0.01622481,
0.018301161,
0.027471706,
-0.0039231037,
-0.022174353,
-0.020084692,
0.012132007,
-0.0045353607,
0.042298976,
0.0454135,
-0.007253915,
-0.009829387,
0.019885045,
0.02269344,
0.007786312,
-0.0375074,
0.019831805,
-0.002701917,
-0.0037434194,
-0.029122138,
0.0013160199,
-0.021508856,
0.016291361,
-0.0093901595,
0.025102539,
0.0009915902,
-0.005220822,
-0.02461007,
0.012085422,
0.01643777,
0.008218885,
-0.018181372,
-0.03689514,
-0.020537231,
-0.037454158,
0.0120188715,
-0.0011280171,
-0.019352647,
0.030293413,
-0.0041992846,
-0.01884687,
0.008391914,
0.0009699616,
0.021721816,
-0.007466874,
-0.013123596,
0.034552593,
-0.010641294,
-0.008405224,
0.018141443,
-0.0007956846,
0.0031627733,
0.01136003,
-0.0032958728,
-0.00835864,
-0.012770883,
-0.0025621627,
0.015013607,
0.022374002,
0.0016288033,
-0.0057099625,
-0.0120454915,
-0.0035404428,
-0.025927754,
-0.020430751,
0.0371081,
-0.036069926,
0.004146045,
-0.0077596926,
0.025555076,
0.029814256,
0.027764525,
0.0077463826,
0.019192927,
0.04362997,
-0.011765983,
0.018287852,
0.011153726,
-0.014161771,
-0.019751944,
0.014960367,
-0.0075600436,
-0.025342118,
0.013789093,
-0.03915783,
-0.033381317,
-0.019578915,
-0.012158626,
0.008518359,
0.014813959,
-0.011459854,
0.039956428,
-0.00028595564,
0.002139572,
0.004292454,
-0.009516604,
0.005506986,
-0.042298976,
0.0065385057,
0.00815899,
-0.012398205,
0.00838526,
-0.004545343,
0.0060826405,
0.010501539,
-0.0187537,
-0.025448596,
-0.0020530575,
-0.0067547923,
-0.0042691617,
-0.013403106,
0.0026253848,
0.0022077856,
-0.012810813,
-0.005134308,
-0.0036535773,
-0.0022909727,
-0.0265267,
0.017968412,
0.015878754,
0.009596463,
-0.0030912326,
0.0012785856,
-0.00084102154,
-0.024197463,
-0.020896599,
0.0023042825,
0.002139572,
0.03535119,
0.029548056,
-0.0030280103,
-0.02096315,
0.00072040025,
-0.052574247,
0.015772274,
0.01038175,
0.013695924,
0.001605511,
0.03524471,
0.0010024045,
0.003643595,
-0.015572624,
0.0015772274,
0.02289309,
-0.025102539,
0.0056101377,
0.0067681023,
0.018021652,
0.025728105,
-0.04291123,
-0.0014457918,
0.040781643,
0.012132007,
-0.018926729,
0.02689938,
-0.009509949,
0.011965632,
-0.0019199582,
0.018154752,
0.012265106,
0.0091239605,
0.015519385,
-0.027950864,
-0.026300432,
0.028776081,
-0.00312118,
-0.01649101,
0.005320647,
-0.01445459,
0.015186637,
-0.01662411,
-0.010122206,
-0.029734395,
0.019246167,
0.003893156,
0.0093635395,
0.003443946,
0.011692778,
0.005912939,
-0.007666523,
-0.021641955,
-0.00833202,
-0.0055535706,
0.009796113,
0.007666523,
0.028110584,
0.008891037,
-0.0046285302,
-0.0022527066,
-0.0024839668,
-0.02270675,
0.003423981,
0.007952686,
-0.029947355,
-0.015931994,
0.0021495547,
0.0005635926,
0.010747773,
0.007653213,
0.0017685577,
-0.021748435,
-0.031810746,
0.0024906218,
-0.015559315,
-0.016597489,
0.021988014,
-0.0033640862,
-0.00033690775,
-0.011280171,
-0.016703969,
-0.00040012994,
-0.021415686,
0.013922192,
0.19847776,
-0.00838526,
0.014268251,
-0.0050245007,
-0.031198489,
-0.0014798985,
0.019911664,
-0.0077330726,
-0.021628646,
-0.0004791577,
0.025075918,
-0.0076066284,
0.0025688175,
-0.0008181451,
-0.0001057516,
-0.012564579,
-0.013762473,
-0.016903618,
-0.021628646,
-0.008817832,
0.010820977,
0.03135821,
0.009616428,
-0.0064187166,
0.015998542,
0.0092836805,
-0.03311512,
0.005956196,
0.0006268148,
0.00045420154,
-0.04131404,
-0.00510436,
0.009816078,
0.0014241631,
0.018021652,
-0.0018850196,
-0.020949839,
0.00082230446,
0.005460401,
-0.014973678,
-0.031863987,
0.023012878,
-0.010880873,
-0.009689633,
-0.0024806391,
0.0042991093,
0.002856645,
-0.015279806,
0.008405224,
0.000522415,
-0.040568683,
0.011539714,
0.007972651,
0.030559612,
0.013789093,
-0.009596463,
0.01854074,
0.01646439,
-0.008618183,
0.028217064,
-0.0077463826,
-0.008338675,
-0.013130251,
0.0009524923,
-0.029920734,
0.036389362,
-0.018860178,
0.0013609409,
0.017861934,
-0.020989768,
0.0103152,
-0.017582424,
-0.02075019,
-0.0021312535,
-0.0023924608,
-0.008984206,
0.02490289,
0.02450359,
0.025382048,
-0.0023192563,
0.0038033142,
-0.015519385,
-0.054331157,
0.027604807,
0.019099757,
-0.03977009,
0.024623381,
-0.01126686,
-0.023119358,
0.03149131,
0.004325729,
-0.014228321,
-0.014587689,
-0.00087762385,
0.009736218,
0.0047083898,
-0.013529549,
-0.0035238054,
0.0060260734,
-0.046132237,
-0.032902163,
0.07911426,
-0.0073603946,
0.0184875,
0.006834652,
0.0051143426,
0.013103631,
-0.021455616,
0.0029980629,
-0.021162797,
0.008072476,
-0.033993576,
0.019978214,
-0.017968412,
0.016783828,
0.010009072,
0.0008609865,
-0.037534017,
0.046105616,
0.0034772207,
0.0063821143,
-0.0014973677,
-0.014294871,
0.028536502,
-0.009935867,
0.00065468246,
-0.018021652,
0.012990497,
0.002953142,
-0.010142171,
0.011379994,
0.0057265996,
-0.009210476,
0.015386285,
0.015333046,
-0.004079495,
0.034233153,
0.00073079864,
-0.004378969,
-0.0039231037,
-0.009882627,
-0.012777538,
0.014747408,
0.010608018,
-0.013190147,
-0.0038731913,
0.021708505,
-0.0006879573,
0.0031261712,
0.00089010195,
-0.01046161,
-0.026100785,
0.011779293,
-0.019805184,
0.0053273016,
-0.007599973,
-0.002038084,
-0.020483991,
-0.01657087,
0.015080157,
-0.038785152,
0.0033191652,
-0.0012802494,
0.0040861503,
-0.019831805,
0.0015231557,
-0.1677052,
0.014587689,
0.019405887,
-0.032236665,
0.033381317,
0.005134308,
0.01631798,
0.0024190808,
-0.003899811,
0.0009882627,
0.012344966,
0.006511886,
-0.021255966,
-0.030745951,
0.004229232,
-0.003959706,
-0.029947355,
0.0332216,
0.04083488,
0.0061791376,
0.023731615,
-0.026406912,
-0.009183856,
-0.016251432,
0.0046152202,
-0.0056567225,
-0.0025172415,
-0.025142469,
0.010661258,
-0.012611164,
-0.005616793,
0.013895573,
0.0187537,
-0.018354401,
0.019272787,
0.010541469,
0.0051576,
0.016078401,
-0.012797503,
0.023971194,
0.042352214,
0.019964904,
-0.0067547923,
-0.005304009,
-0.021708505,
0.012957222,
0.022427242,
-0.02289309,
-0.0051942025,
-0.007187365,
0.005370559,
-0.022427242,
0.017489254,
-0.011147071,
0.016051782,
-0.0019948266,
-0.005873009,
0.015359665,
0.013250041,
0.00022044581,
-0.035164848,
-0.022161042,
0.041473757,
-0.021162797,
0.0060560205,
-0.027871005,
-0.002179502,
-0.006232377,
-0.012005562,
0.02072357,
-0.04341701,
0.012078767,
-0.01151975,
-0.00568667,
0.013349866,
0.025328808,
-0.022081183,
0.018008342,
-0.014294871,
0.0015098458,
-0.011180346,
0.015945302,
-0.0038765187,
-0.0028699548,
0.002758484,
-0.013063702,
0.009210476,
-0.00077987905,
-0.0024473644,
-0.0011288489,
-0.0030529664,
-0.005280717,
0.010581398,
-0.013123596,
0.008418534,
0.009197165,
0.01850081,
0.001657087,
-0.0075800084,
0.0031893933,
0.013309936,
-0.032183424,
0.021056319,
0.005630103,
0.028536502,
-0.023931265,
-0.01834109,
0.007513459,
0.06165162,
-0.007513459,
-0.018221302,
0.020830048,
-0.0061358805,
0.02268013,
2.8595565e-7,
0.020883288,
-0.00624236,
-0.007460219,
-0.006428699,
-0.03300864,
0.06686912,
0.017555805,
-0.01860729,
0.0064386814,
-0.0068679266,
-0.014640929,
-0.13522895,
-0.021349136,
0.021495545,
-0.005101033,
-0.016344601,
0.050630994,
0.011033936,
0.033700757,
-0.016291361,
0.016158262,
-0.023558587,
-0.023119358,
-0.012158626,
-0.003410671,
-0.0012228503,
0.016876997,
-0.010714498,
-0.01855405,
0.0047815945,
0.039983045,
0.014880508,
-0.0070675756,
-0.010448299,
-0.015892062,
0.0032193407,
-0.001476571,
-0.017582424,
0.015120087,
0.02092322,
0.013962123,
0.00026453496,
0.00051576,
0.012491374,
0.0044588284,
-0.036735423,
-0.0022560342,
-0.021442305,
-0.016158262,
0.016797138,
-0.023598516,
-0.0014615973,
0.013682614,
0.002610411,
0.019445816,
0.0329554,
-0.011872463,
0.010215376,
0.0037933316,
-0.00675812,
-0.005689997,
-0.027005859,
-0.0030280103,
-0.047915768,
-0.022067873,
0.026207263,
-0.02914876,
0.024290632,
0.020949839,
-0.0019415868,
-0.011306791,
-0.0055668806,
0.0037833492,
-0.009130616,
0.009456709,
0.0025571713,
-0.0048514716,
-0.007373704,
-0.014720789,
0.019512365,
-0.036442604,
-0.006801377,
-0.02060378,
-0.016743898,
-0.013030427,
-0.013416415,
0.00831871,
-0.013935503,
-0.03529795,
0.011300135,
0.0031810745,
-0.011160381,
-0.011839188,
0.021761745,
-0.023252457,
0.02672635,
-0.008651458,
0.00829209,
-0.015146706,
-0.024942819,
-0.011193655,
-0.010967387,
0.03090567,
-0.038492333,
-0.017302915,
-0.006901202,
0.020297652,
-0.023505347,
-0.00093502295,
0.0019998178,
0.011013972,
-0.019019898,
0.011326755,
-0.052813824,
0.008777902,
0.008425189,
-0.007879482,
0.0056134653,
-0.0127376085,
-0.0086980425,
0.0040961327,
0.00838526,
-0.0035038406,
-0.023185907,
0.0031378174,
-0.021788364,
0.018407641,
-0.015239877,
0.009197165,
0.031810746,
-0.008491739,
0.030373273,
0.032050326,
-0.005330629,
0.008797867,
0.0058264243,
0.014414661,
0.023891333,
-0.014707479,
-0.00021836613,
0.023931265,
-0.0051742373,
-0.009456709,
0.0016995124,
-0.017475946,
-0.020444062,
-0.0035437704,
0.008977552,
-0.0046584774,
0.035164848,
0.031438068,
0.013868953,
0.038359236,
-0.027737906,
-0.04344363,
-0.0065418333,
0.025568387,
0.011632884,
0.028350163,
-0.032156803,
0.017609045,
0.0077530374,
-0.038598813,
0.044135746,
0.033620898,
-0.014973678,
-0.00932361,
-0.029494816,
0.007400324,
-0.010574744,
-0.023239147,
-0.016810449,
0.0015630856,
-0.00056650414,
0.016025163,
-0.0043024365,
0.0123116905,
-0.004422226,
-0.016916929,
-0.031145249,
-0.011093832,
0.018034963,
-0.004488776,
-0.041074462,
0.004591928,
0.01834109,
-0.019618845,
0.011206966,
-0.0073071546,
-0.027844384,
-0.0012062129,
0.0023758234,
0.004235887,
0.022254212,
-0.0077530374,
-0.0069145113,
0.0016512639,
0.025714796,
0.023492036,
0.01663742,
0.032582723,
-0.0096297385,
-0.0045752903,
0.003327484,
0.0040262556,
0.010095586,
0.009583154,
0.012664404,
0.021575406,
-0.017276296,
0.0113201,
-0.0063421843,
0.028776081,
0.005290699,
-0.003713472,
0.007859517,
-0.009423435,
-0.011699433,
0.025714796,
-0.0063821143,
-0.03087905,
-0.0010989015,
-0.021322517,
0.0077663474,
-0.007899446,
0.0056101377,
0.012804158,
0.00087263266,
0.023066118,
-0.009563189,
0.0075533884,
-0.019645466,
0.03489865,
0.009809422,
0.03287554,
-0.0053239744,
-0.010055657,
0.007879482,
0.0039430684,
0.013775784,
-0.025022678,
0.02683283,
-0.007001026,
0.013948812,
-0.0027618117,
-0.015399596,
0.0042558517,
-0.021442305,
-0.00510436,
0.0072805346,
-0.013855643,
-0.0090174815,
0.065165445,
-0.003280899,
-0.0325561,
-0.0064054066,
-0.019924974,
0.026260503,
0.0040262556,
0.008551634,
-0.027658045,
-0.036229644,
0.019911664,
0.00084642874,
0.030373273,
-0.037454158,
-0.010115551,
0.017396085,
-0.0061691552,
0.025980994,
-0.021149488,
-0.008125716,
0.010940767,
0.012943912,
0.0067315,
-0.0015439525,
-0.025368737,
-0.0030596214,
0.028536502,
-0.02289309,
-0.0059295762,
-0.03708148,
0.014973678,
-0.0050710854,
-0.027418468,
-0.02274668,
0.00511767,
-0.0020480664,
-0.008145681,
0.012544614,
0.022759989,
0.0039031387,
0.017076647,
0.00049496326,
-0.017036717,
-0.037906695,
0.00831871,
-0.0022676804,
-0.011286825,
-0.008598219,
0.005769857
] |
Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2. | [
-0.0388621,
-0.0011739312,
0.0027394542,
-0.03894312,
-0.014785963,
0.014677937,
-0.00986406,
0.013192589,
-0.02024124,
-0.01396227,
-0.00879731,
-0.002805282,
-0.004722731,
0.014421377,
0.007926356,
-0.010728262,
0.023590025,
0.009891067,
0.03194848,
-0.011464185,
-0.010782275,
0.014664434,
-0.0008962724,
-0.019269012,
-0.008506992,
-0.0030601542,
0.018917931,
-0.030517146,
-0.0018921306,
-0.021578053,
-0.001644854,
-0.0006203015,
0.0038585286,
-0.009155144,
-0.0018735637,
-0.009566991,
0.004017191,
-0.02138901,
0.006167569,
-0.007784573,
0.025480468,
0.018647866,
0.0029436895,
0.020997418,
-0.007838585,
-0.012071827,
-0.0040982096,
-0.010485206,
-0.0066638105,
0.0033454085,
0.004277127,
0.008642023,
-0.03348784,
0.0013351252,
0.008398967,
0.0009815111,
0.030895235,
0.0034483701,
-0.00080386014,
-0.005063686,
-0.00023820423,
0.0039091655,
-0.023333464,
0.01028941,
-0.014596919,
0.013732716,
0.020403279,
-0.0057692262,
0.020821877,
0.013894754,
0.019863151,
-0.0010937562,
0.008999858,
0.010870046,
0.023576522,
-0.031867463,
-0.04248095,
0.0074740006,
0.0059413915,
0.0085947625,
0.034865163,
0.0044020307,
-0.00557343,
0.0020727355,
0.018431816,
-0.007825082,
-0.00082284893,
0.029328868,
0.014299849,
-0.015056026,
0.032974724,
0.016865449,
0.024373207,
0.002547034,
-0.007872344,
-0.0015410484,
0.015083033,
0.02336047,
-0.007676548,
-0.039699297,
-0.01396227,
0.020781366,
-0.030463135,
-0.009911321,
-0.03902414,
-0.00866903,
-0.006221582,
-0.024656774,
0.021321494,
-0.011376414,
-0.024562253,
0.026844287,
-0.0053776344,
-0.038916115,
0.026385179,
-0.0035985927,
0.02399512,
0.042210884,
-0.016122775,
-0.0002512854,
0.03154339,
0.03483816,
0.010174633,
-0.00977629,
0.040590506,
0.014596919,
0.007528013,
-0.0012346954,
0.0006810657,
-0.005745596,
-0.007656293,
0.023941107,
-0.00090386794,
0.018985447,
-0.029868996,
0.026884796,
-0.0084327245,
-0.011092848,
0.0029690077,
-0.018458823,
-0.0042433687,
0.032731667,
-0.059251875,
-0.0140027795,
-0.0032829563,
0.022982383,
0.01874239,
0.007980369,
0.006528779,
0.0026027346,
-0.005529545,
-0.019903662,
0.007757567,
-0.019485064,
0.017554112,
0.016554877,
0.0026331167,
0.02967995,
0.012861762,
-0.019998183,
0.008257184,
-0.0043952796,
0.014110805,
-0.0014845039,
0.013381634,
0.02608811,
-0.00461133,
0.008729794,
-0.0057185893,
-0.007946611,
0.001127514,
0.0102489,
-0.04032044,
0.021037927,
-0.005836742,
0.007365975,
0.003433179,
-0.007825082,
-0.021145953,
0.012186604,
0.00008312884,
-0.008317948,
0.004398655,
0.014934498,
-0.02130799,
0.003659357,
0.0021976398,
-0.015866216,
0.0020507928,
0.0046957247,
-0.0009705398,
0.015812203,
0.001514042,
-0.0042433687,
-0.6347567,
-0.006819097,
0.020349266,
-0.005772602,
0.00947922,
0.011632974,
0.0027833392,
-0.017284047,
0.018431816,
0.031894468,
-0.006866358,
0.009938328,
0.012267623,
-0.01840481,
-0.023603527,
-0.05012374,
0.006781963,
-0.011018581,
0.012011063,
0.0077238088,
-0.019917164,
0.0033943574,
-0.021294488,
0.027735496,
0.0024373208,
-0.0028457914,
0.017797168,
0.010559473,
-0.015461121,
0.005863748,
-0.018836912,
0.020173725,
-0.014394371,
-0.006781963,
0.053013414,
0.001531765,
0.0012515744,
0.008311196,
0.014664434,
0.03194848,
-0.030625172,
0.015515134,
0.017945703,
-0.009958582,
-0.017297551,
-0.014853478,
0.013975773,
0.018539842,
0.005364131,
-0.0024170661,
-0.015474624,
0.01046495,
-0.008533998,
-0.0068123452,
-0.010471703,
0.008547502,
0.008527247,
-0.011923293,
0.0009815111,
-0.026655242,
-0.02429219,
0.0036019685,
-0.012004311,
-0.01656838,
0.008466483,
0.0012372272,
-0.021402512,
0.016028253,
0.013617939,
0.0048105014,
0.014070295,
0.020565316,
0.0054215197,
0.013368131,
-0.0026381803,
0.012882017,
-0.010167881,
-0.00069414696,
0.005532921,
0.017108507,
-0.019660605,
0.011754503,
-0.017108507,
-0.011126606,
0.04445241,
-0.020335762,
-0.0013933575,
0.013611187,
0.01814825,
-0.015042523,
0.019066466,
0.010816033,
-0.016068764,
-0.029031798,
-0.029193837,
0.02122697,
0.0069406256,
0.011153612,
0.037727837,
-0.028680718,
-0.025912568,
0.014920995,
0.0033741028,
-0.0012920839,
0.0068596066,
-0.009445462,
-0.024643272,
0.0003515042,
0.012179852,
0.005431647,
-0.0034247395,
-0.026115116,
-0.021537544,
0.004074579,
0.00069372496,
-0.03005804,
0.012051572,
-0.0007658825,
0.0005620691,
-0.029706957,
0.0068326,
-0.01840481,
0.02057882,
-0.017446086,
0.00561394,
0.0030567783,
0.0076157837,
0.008257184,
-0.000628741,
-0.019296018,
0.010647244,
-0.0049151513,
0.01597424,
-0.02565601,
0.022739325,
0.00319181,
0.019890158,
-0.0061945757,
0.01554214,
-0.037079684,
-0.02395461,
-0.00486789,
0.005256106,
-0.008216674,
-0.011099599,
-0.020295253,
-0.014110805,
0.002209455,
0.017284047,
0.008986355,
0.02352251,
-0.00047514253,
-0.031219311,
0.01469144,
0.00076630444,
-0.017554112,
-0.03181345,
-0.009209157,
-0.032299563,
-0.014556409,
0.014650932,
-0.0054417746,
-0.017067997,
-0.010390683,
-0.026533714,
-0.016892456,
0.012186604,
0.013604436,
-0.004348018,
-0.026115116,
0.014259339,
-0.006008907,
-0.016028253,
-0.0016566692,
0.016514368,
0.024683781,
-0.009114634,
0.0131453285,
-0.0034078606,
-0.02016022,
-0.005289864,
-0.0011967177,
-0.042507954,
-0.0077913245,
0.029625937,
0.01844532,
0.022536779,
0.01660889,
0.015555643,
0.027897533,
-0.0101476265,
0.007784573,
-0.013779977,
0.027451929,
0.01939054,
-0.015110038,
0.023590025,
0.013226347,
0.0022297096,
0.017513601,
0.039996367,
-0.022415249,
0.012281126,
-0.000088561756,
-0.0010287722,
-0.035675354,
0.0034146123,
-0.020403279,
-0.0077913245,
-0.00034306472,
-0.0041522225,
0.004115089,
0.006994638,
-0.0076292865,
-0.009195654,
0.003936172,
-0.014205326,
0.015420611,
-0.0034736886,
0.0049455334,
-0.015231567,
-0.018175257,
0.023603527,
-0.016298316,
0.004435789,
-0.0054586534,
0.011578961,
0.003043275,
0.01157221,
-0.0035378286,
-0.00059709296,
0.020956907,
-0.018931434,
0.0050029214,
0.002079487,
-0.009067373,
-0.009283424,
-0.012828005,
0.027870527,
-0.004982667,
-0.0018398059,
-0.010924058,
0.02916683,
-0.021915633,
0.00063085085,
-0.02472429,
0.026655242,
0.03718771,
-0.0106269885,
0.01037718,
-0.016838443,
0.012119088,
-0.014272843,
-0.0054687806,
0.009580494,
-0.015596152,
0.011423675,
0.025615498,
0.056713283,
0.011693738,
0.010782275,
0.0012752049,
0.008419221,
-0.019674107,
-0.020200731,
0.0011916541,
0.0030770332,
-0.0059582703,
-0.009418456,
-0.018161753,
-0.023873592,
-0.0028778615,
0.007305211,
-0.0089660995,
0.023414483,
0.004385152,
-0.0076157837,
0.01848583,
0.046261836,
0.004027318,
-0.007656293,
-0.012800998,
0.048962466,
0.023265949,
-0.012220362,
-0.013894754,
-0.024386711,
0.0059110094,
0.014070295,
0.02057882,
0.018674873,
0.00070722814,
-0.010998325,
0.018026723,
-0.0069271224,
-0.015299083,
0.02843766,
-0.010721511,
-0.0020339137,
-0.023009388,
0.01690596,
0.0115924645,
0.012146095,
-0.00802763,
0.022347733,
0.00017754549,
-0.014893988,
-0.0060190344,
-0.0028289126,
-0.009215908,
0.016635897,
-0.0130913155,
0.003350472,
-0.022307225,
0.0072782044,
-0.004871266,
0.0034568096,
0.016028253,
-0.004469547,
0.005772602,
-0.045451645,
-0.02677677,
0.025601996,
0.0008819253,
0.038294967,
0.038916115,
-0.013037303,
0.016784431,
-0.021537544,
0.012713227,
-0.007494255,
-0.014178321,
0.015812203,
-0.0008574508,
-0.011693738,
0.023765566,
0.00008360356,
0.01887742,
-0.013388385,
0.008817565,
0.017554112,
-0.048476353,
0.00020993198,
0.0074402425,
0.005917761,
0.010127372,
-0.0024120023,
0.033838924,
0.01627131,
0.0020659838,
0.014866982,
0.016109273,
-0.0028306004,
-0.017851181,
-0.0043243878,
0.013712461,
-0.0019697738,
0.012402655,
0.0027478936,
-0.019417547,
0.026601229,
-0.004641712,
-0.008061388,
0.0052459785,
0.022145186,
0.008959348,
-0.0016575132,
-0.009148393,
0.007919605,
-0.015825706,
-0.019147484,
0.008250432,
-0.007183682,
-0.009249666,
0.024602761,
-0.015987745,
-0.007784573,
-0.02938288,
0.010208391,
-0.028086578,
-0.005654449,
-0.008905335,
0.0020457292,
-0.026466198,
-0.018215766,
-0.013894754,
-0.0015342968,
-0.019066466,
-0.0021149328,
-0.011781509,
-0.0057996083,
-0.01421883,
-0.036404524,
-0.004108337,
-0.0027343903,
-0.045667697,
-0.014259339,
-0.0034939433,
0.01814825,
0.01613628,
0.012584947,
-0.028680718,
0.014191824,
0.014502396,
-0.017999716,
-0.006157442,
0.0035682106,
-0.016460355,
0.01712201,
-0.0060730474,
0.0021301238,
-0.0056679524,
-0.02770849,
0.0057185893,
0.0116464775,
-0.0034163,
0.019701114,
-0.028734729,
-0.016365834,
0.04048248,
0.010633741,
0.05385061,
0.022712318,
-0.0041218405,
-0.0067988425,
-0.01583921,
-0.041643754,
-0.022428753,
-0.018850414,
-0.01712201,
0.011713994,
0.017297551,
-0.01357743,
-0.004709228,
-0.00091315137,
-0.012544438,
0.0007958426,
0.025345435,
0.029139824,
0.0037640065,
-0.008912087,
0.017918697,
-0.012024566,
0.00837196,
0.004786871,
-0.01840481,
0.018337294,
-0.004415534,
-0.025007857,
0.024670277,
-0.01353692,
-0.018634364,
-0.018863918,
0.008608266,
0.012281126,
0.038538024,
0.013233099,
-0.030760204,
0.0030398995,
-0.014016283,
-0.025453461,
0.0131453285,
-0.018364301,
-0.0055497997,
-0.00866903,
0.03834898,
0.01046495,
-0.012571444,
0.040725537,
-0.02916683,
0.001692959,
-0.006302601,
-0.010809282,
0.016419845,
-0.003625599,
0.004530311,
-0.018242773,
-0.0065355306,
0.0031968737,
-0.010701256,
0.012314884,
-0.013644946,
0.023765566,
0.021267481,
0.029436894,
0.0036019685,
-0.025129385,
0.026911803,
0.017446086,
0.002238149,
0.016865449,
0.010518963,
-0.013644946,
0.013057558,
0.0071971854,
0.009708773,
-0.0013781665,
-0.02322544,
0.017486595,
0.014259339,
-0.00014484252,
-0.0247648,
0.0047801193,
-0.01844532,
-0.01682494,
0.005897506,
-0.0064713904,
0.0152855795,
-0.02480531,
0.0014642492,
0.01357743,
-0.009702022,
0.0023968113,
-0.026520211,
0.02071385,
-0.011248134,
0.034352046,
-0.0015351408,
0.036431532,
0.0022685314,
0.0023225439,
-0.003963178,
0.008095146,
0.0049252785,
-0.0035884653,
0.02984199,
0.016014751,
-0.017473092,
-0.004023942,
-0.009850557,
-0.017189525,
-0.0033589117,
-0.015947234,
-0.007912853,
-0.008615018,
-0.002499773,
0.0043581454,
-0.03108428,
-0.0014937873,
0.0108430395,
-0.006187824,
0.0108903,
0.014826472,
-0.011268389,
0.013698958,
-0.02053831,
0.00017111038,
-0.02711435,
0.01968761,
0.035729367,
0.00296732,
-0.0012363833,
-0.0050974437,
0.0070081414,
0.016473858,
0.036728602,
0.037592802,
-0.02045729,
-0.007284956,
0.0085947625,
-0.005576806,
-0.017230036,
-0.031273324,
-0.012301381,
-0.03224555,
0.006538906,
0.006420754,
-0.0048442595,
-0.019079968,
-0.010917307,
-0.016082266,
-0.012706475,
0.005887379,
-0.002403563,
-0.0025284672,
0.002111557,
0.0060325377,
-0.008756801,
0.0025740403,
0.0043784003,
-0.0054215197,
-0.017392073,
-0.01968761,
0.023009388,
0.0010363677,
0.0439933,
0.01353692,
0.019930668,
-0.0026820656,
-0.0072174403,
0.0042096106,
-0.007318714,
-0.011626223,
0.04002337,
-0.021686079,
-0.0056780796,
0.014232333,
-0.015353096,
-0.0009224348,
0.022266714,
-0.006883237,
-0.021240475,
-0.009202405,
-0.0029470653,
0.0060055316,
-0.013219596,
-0.036647584,
-0.002352926,
-0.02130799,
0.011673484,
-0.021402512,
-0.03151638,
0.01925551,
-0.035459306,
-0.0044931774,
0.003642478,
0.018607358,
0.04018541,
0.02237474,
0.0015587714,
-0.0067988425,
-0.0042298655,
-0.01477246,
0.011383166,
-0.0123959035,
-0.00074140803,
-0.043750245,
0.0070824088,
-0.019052962,
-0.032380585,
0.015623159,
-0.013989276,
-0.019309523,
0.009560239,
-0.007122918,
0.008176165,
0.01759462,
-0.02784352,
0.010134123,
-0.0058941306,
0.019579586,
-0.010302912,
0.011200873,
0.0030010778,
-0.0068055936,
0.008054636,
0.0023006012,
0.003080409,
-0.0056679524,
-0.0122878775,
0.012841508,
0.010269155,
-0.017567614,
0.0019377038,
0.0021807607,
0.000075691554,
0.003466937,
0.0009376258,
-0.012699724,
-0.010829536,
-0.034190007,
0.036755607,
0.0013655073,
-0.020943405,
0.014313352,
0.0010245524,
-0.005624067,
0.0022803466,
-0.027060337,
0.0048442595,
0.0043750247,
-0.016244303,
-0.03151638,
-0.006994638,
-0.0058401176,
0.022604294,
0.012909023,
-0.035729367,
-0.01041769,
-0.022968879,
-0.025926072,
-0.021740092,
0.0063127284,
0.0038619044,
-0.0013106507,
0.019012453,
0.0039024139,
0.0010059855,
0.008945845,
0.01840481,
0.0046720942,
-0.025102379,
0.0099315755,
0.00777107,
0.023009388,
0.023373974,
-0.036269493,
-0.012429661,
0.042372923,
-0.02024124,
-0.0140027795,
0.03578338,
-0.017459588,
0.014299849,
-0.02664174,
0.008972852,
-0.009114634,
0.0076427897,
0.026074607,
-0.03270466,
-0.019647101,
0.012659214,
0.0217806,
-0.035972424,
0.0021048053,
0.00082791265,
0.01848583,
0.008128904,
-0.045613684,
-0.016973475,
0.0016524495,
-0.02024124,
0.012483673,
0.023009388,
-0.010167881,
0.00461133,
0.027384413,
-0.019187994,
-0.023711553,
-0.011963801,
-0.015056026,
-0.01844532,
0.0068292245,
-0.0045843236,
-0.005863748,
-0.014353861,
-0.008506992,
-0.005978525,
0.019525573,
-0.014637428,
-0.02822161,
-0.013192589,
0.02967995,
-0.0012279438,
-0.013341124,
0.003966554,
-0.0038450256,
-0.008493489,
-0.008736546,
0.0076697962,
0.023468496,
-0.017945703,
0.017581118,
0.0024103145,
-0.022482766,
-0.013273609,
0.0020389776,
-0.02211818,
-0.02087589,
0.036134463,
0.1780257,
-0.008101897,
-0.0024980851,
0.00061354996,
-0.011815267,
-0.030463135,
0.019566081,
-0.0085407505,
0.013314118,
-0.00280697,
0.012780743,
0.007838585,
-0.011018581,
0.004044197,
0.024616266,
-0.021064933,
-0.008439477,
-0.020511303,
-0.015407108,
-0.007892598,
0.009047119,
0.0053269975,
-0.021497034,
-0.029598933,
0.037430767,
0.0010304601,
-0.025858555,
-0.0030922242,
-0.012220362,
-0.0042602476,
-0.034271024,
-0.007494255,
0.012794246,
-0.008466483,
0.0069068675,
0.0012836443,
-0.011052338,
-0.00017343124,
0.0028120335,
0.0024896455,
-0.0032508862,
0.015299083,
0.009101131,
-0.009317182,
0.008729794,
0.017743155,
0.00062789704,
-0.028464666,
-0.021186462,
0.0039733057,
-0.044776488,
0.040968593,
0.013057558,
0.052635327,
0.0038348981,
-0.014880485,
0.01182877,
-0.01374622,
-0.016757425,
0.030868229,
-0.013388385,
0.0014937873,
-0.028896768,
0.004948909,
-0.0038348981,
0.040725537,
-0.0019427675,
0.017081501,
0.02693881,
-0.014948001,
0.0026938808,
-0.011052338,
-0.013010297,
0.0036458538,
-0.0026634987,
-0.011335905,
0.020376272,
0.02565601,
0.030409122,
0.047801193,
0.014853478,
0.008993106,
-0.03232657,
-0.0029065558,
-0.0064410083,
-0.023319962,
0.028572692,
0.00049750716,
-0.038457006,
-0.026196135,
0.016946469,
-0.024373207,
-0.019323025,
-0.009080877,
0.017486595,
-0.018161753,
-0.003774134,
0.0209299,
-0.021118946,
-0.0016195355,
-0.038970128,
0.081127,
0.0021166208,
0.010518963,
-0.007912853,
-0.0075617707,
-0.008088394,
0.022536779,
-0.026547218,
-0.021132449,
0.012780743,
-0.01951207,
0.022617796,
-0.009627755,
0.008459731,
0.005708462,
0.023711553,
-0.03424402,
0.017648634,
-0.0013806983,
-0.008479986,
-0.022995885,
-0.011092848,
0.030544152,
-0.005738844,
-0.0011882783,
-0.009614252,
-0.024994353,
0.005968398,
-0.021145953,
0.009425207,
-0.008338203,
0.017527105,
-0.008344954,
0.025966581,
-0.039294202,
0.030409122,
-0.021686079,
-0.03578338,
0.0072917077,
-0.005543048,
-0.002082863,
0.0009823551,
0.006822473,
0.0015233255,
-0.022860853,
0.02612862,
0.022334231,
0.004030694,
0.013671952,
-0.029436894,
-0.04180579,
0.015177554,
-0.015366599,
0.0048442595,
-0.02130799,
-0.0028272246,
-0.040455475,
0.024629768,
0.012301381,
-0.024562253,
0.0037336245,
0.008655527,
-0.018593855,
0.0018178632,
-0.0035749623,
-0.17100404,
-0.0014321791,
0.0064950213,
-0.026223142,
0.013530169,
0.020268247,
0.01131565,
0.0018887548,
-0.0008988042,
0.0014963192,
0.015812203,
0.0084867375,
-0.0063903714,
-0.0414277,
0.015636662,
0.011079345,
-0.038159937,
0.025331933,
0.036323506,
0.004466171,
0.028923774,
-0.0025706645,
0.01195705,
0.00012870201,
-0.02199665,
0.0011013517,
0.0015511757,
-0.018283281,
-0.023968114,
-0.01652787,
-0.0315974,
0.0030719694,
0.015906725,
-0.0024271933,
0.025764033,
0.0089660995,
-0.021537544,
0.0064140023,
0.0016794559,
0.021956142,
0.0041387193,
0.030652178,
-0.012227113,
0.016797934,
-0.023684546,
0.048989475,
0.014367364,
-0.006228334,
0.017405577,
0.000105493455,
0.019782133,
-0.020214234,
0.002660123,
0.0022685314,
0.03653956,
-0.02105143,
-0.00879731,
0.031192305,
-0.023184929,
-0.0106269885,
0.00012859653,
-0.034568094,
0.051555075,
-0.019593088,
0.0131993415,
-0.0043817763,
-0.022050664,
0.02199665,
-0.024602761,
-0.0030027658,
0.010491957,
-0.010451447,
-0.0038348981,
0.007143173,
0.016203795,
0.0089660995,
0.00738623,
0.010910555,
0.019201497,
-0.0091281375,
-0.0024828939,
0.01690596,
-0.008804061,
-0.0034601854,
0.014948001,
-0.021321494,
-0.010782275,
0.016554877,
0.0209299,
-0.0024457602,
0.011977305,
-0.0053742584,
0.021145953,
-0.0070486506,
0.021213468,
0.002854231,
-0.019120477,
-0.021591557,
-0.008871578,
-0.0153395925,
0.003274517,
-0.013233099,
-0.010849791,
-0.010194887,
0.036323506,
0.005772602,
-0.022496268,
0.0006840196,
0.042507954,
-0.00040403992,
0.005141329,
-0.004094834,
0.011295395,
0.028167596,
0.012166349,
0.026209638,
-0.017405577,
-0.014758957,
0.0019883406,
-0.020254744,
0.08544801,
0.0070013897,
-0.0017621627,
0.01781067,
-0.004398655,
-0.01895844,
-0.1294143,
0.0026213014,
0.010687753,
-0.0030652178,
-0.023076905,
0.024076138,
0.012402655,
0.03505421,
-0.0056308187,
0.020214234,
-0.018323792,
0.0024474482,
-0.000645198,
-0.017054494,
-0.009371195,
0.009978837,
0.018539842,
-0.008216674,
-0.00057937007,
0.04445241,
-0.017837677,
-0.025169894,
0.015299083,
0.007609032,
-0.0060629197,
-0.0059312643,
-0.021834614,
-0.008918839,
0.008331452,
0.0013165583,
-0.013165583,
-0.039807323,
0.014718447,
0.01635233,
-0.03807892,
-0.0034939433,
-0.015434114,
-0.03437905,
0.011254886,
-0.0021470028,
-0.0053877616,
0.01955258,
0.0035243253,
-0.0017638506,
0.0007304367,
0.007143173,
0.0036222234,
0.00040108612,
0.005414768,
0.01306431,
-0.014448384,
-0.020173725,
-0.040968593,
-0.029193837,
0.018769396,
-0.01344915,
-0.00014431505,
0.008500241,
-0.032002494,
-0.011038835,
-0.0037201212,
0.022604294,
-0.036863633,
0.0022752827,
0.0038956623,
-0.033190772,
-0.015771694,
-0.033298798,
0.03880809,
-0.02267181,
-0.0070081414,
0.025980085,
0.0024086265,
-0.017770162,
-0.018985447,
0.032434598,
-0.041049615,
-0.010593231,
0.012584947,
-0.018809905,
0.0010515588,
-0.0157987,
0.046342853,
-0.026250148,
0.016122775,
0.02571002,
0.008608266,
0.0039429236,
-0.0035040707,
-0.00016815656,
-0.027168363,
0.034298033,
-0.011876031,
-0.011903037,
-0.032083515,
0.003966554,
-0.021483531,
-0.0095062265,
0.021429518,
0.011214376,
-0.0076225353,
-0.004628209,
-0.055362966,
0.009546735,
0.011747751,
-0.014313352,
0.00012838554,
-0.019215,
0.014124308,
0.016446851,
-0.0076157837,
0.0076495414,
-0.0014085487,
0.012800998,
-0.008831068,
-0.017365066,
-0.021118946,
-0.030517146,
0.028815748,
-0.015893223,
0.036161467,
0.04048248,
0.0038922864,
-0.0141648175,
0.005833366,
0.01267947,
-0.004115089,
-0.018350797,
-0.013496411,
0.01037718,
0.0055025388,
0.0021672575,
-0.011626223,
-0.033082746,
-0.02535894,
0.013017048,
-0.01392176,
0.015555643,
-0.0024406966,
0.03167842,
0.01933653,
0.004398655,
-0.018823408,
-0.04021242,
-0.0021723213,
-0.010539218,
-0.0019765254,
0.019147484,
-0.049799662,
-0.005411392,
0.022766331,
-0.011477688,
0.017257042,
0.0035648348,
0.012132592,
-0.016554877,
-0.031867463,
-0.00806814,
-0.018229268,
-0.028410653,
0.0066064224,
-0.01994417,
0.013908257,
0.019120477,
-0.0033116506,
-0.017486595,
-0.006630053,
-0.008770304,
-0.01656838,
0.009837054,
-0.0107890265,
-0.03791688,
-0.048746414,
0.021024425,
0.016811438,
-0.0066773137,
0.005624067,
-0.001177307,
-0.014934498,
-0.008290942,
-0.024197666,
0.004499929,
-0.0039733057,
-0.0074402425,
0.003350472,
0.014650932,
0.0016878953,
0.004239993,
-0.023630533,
0.0068933642,
-0.0050569344,
0.013732716,
-0.0056476975,
0.0042028595,
0.012868513,
0.017473092,
0.027465433,
0.021443022,
0.004948909,
-0.0030010778,
0.0058502452,
0.016149782,
-0.00024073606,
0.010978071,
0.010633741,
-0.025237411,
0.0099855885,
0.016784431,
-0.004948909,
-0.022266714,
0.012632208,
0.010937561,
0.002319168,
-0.0040543247,
-0.007494255,
0.009155144,
-0.006140563,
-0.0027698362,
0.010167881,
-0.012220362,
-0.014380868,
0.03483816,
0.006218206,
0.013246602,
0.028410653,
-0.011666732,
0.017392073,
0.012402655,
0.024184164,
-0.01656838,
-0.0010878486,
-0.01502902,
0.025547983,
0.0027630846,
-0.046531897,
-0.010957817,
0.012247369,
0.012969787,
-0.0014861918,
0.012584947,
-0.005370883,
0.08204521,
0.017162519,
-0.015717681,
-0.005705086,
-0.019363536,
0.0414277,
0.0013072749,
0.017013984,
-0.006167569,
-0.04307509,
0.003240759,
-0.026668746,
0.045505658,
-0.0009536608,
-0.005040055,
0.01613628,
0.0035378286,
0.025048366,
-0.013084564,
-0.048233297,
0.021753594,
-0.02024124,
-0.012848259,
0.016851947,
-0.028464666,
0.022712318,
0.028653711,
0.011376414,
0.0037099938,
0.0013874499,
0.021321494,
-0.011349408,
-0.017081501,
0.002030538,
0.008263935,
0.003436555,
0.009499474,
0.010518963,
0.040104393,
0.018998949,
0.01759462,
0.0005544736,
0.006468015,
-0.011565459,
0.014367364,
0.016770927,
-0.016406342,
0.004928654,
-0.006417378
] |
Bistability in developmental pathways refers to the generation of binary outputs from graded or noisy inputs. Signaling thresholds are critical for bistability. Specification of the left/right (LR) axis in vertebrate embryos involves bistable expression of transforming growth factor beta (TGFbeta) member NODAL in the left lateral plate mesoderm (LPM) controlled by feed-forward and feedback loops. Here we provide evidence that bone morphogenetic protein (BMP)/SMAD1 signaling sets a repressive threshold in the LPM essential for the integrity of LR signaling. Conditional deletion of Smad1 in the LPM led to precocious | [
-0.026712883,
-0.0039170664,
-0.0041160067,
-0.001855633,
-0.022912437,
0.009542275,
-0.026836364,
0.0011859244,
-0.028839486,
-0.03572694,
0.046702955,
0.008273173,
0.0039479365,
0.009652035,
0.0029240798,
-0.0071892915,
0.027975125,
0.015681986,
0.0035329056,
0.03018405,
-0.01952359,
0.0030407,
-0.0013162646,
-0.032928053,
-0.0062837703,
0.003683826,
0.021965755,
-0.046593197,
-0.030019408,
-0.000050110237,
0.008163413,
0.010687897,
-0.0070246514,
-0.0011156093,
0.012457781,
-0.002394144,
0.009041495,
-0.0022860987,
0.014502063,
-0.0006619911,
0.016834468,
0.017067708,
-0.01800067,
-0.0065170107,
-0.016367987,
-0.011209258,
0.020799553,
-0.00604367,
-0.02539576,
0.0047128275,
0.00607454,
-0.0034180004,
-0.04217535,
-0.013370162,
-0.0065375906,
0.011565979,
0.027124483,
0.0128213605,
0.023680758,
-0.014392303,
0.0017544478,
-0.0040474064,
-0.017012827,
0.004208617,
-0.0013582822,
0.0017441579,
-0.005549749,
0.015489905,
0.019647071,
-0.00080562255,
0.03262621,
0.01874155,
-0.011346458,
-0.010406637,
0.016354267,
-0.0004328238,
-0.01812415,
-0.003721556,
-0.029717568,
0.004294367,
0.017534189,
-0.009782376,
0.007007501,
0.028482767,
0.011751199,
-0.010982878,
0.004815728,
-0.0039033464,
0.0032979504,
-0.022500837,
0.01882387,
0.032104854,
0.004784858,
0.013761182,
-0.015764305,
-0.0086093135,
-0.009405076,
0.041269828,
0.0063317902,
-0.015352705,
-0.016628668,
-0.005642359,
-0.010886838,
-0.00626662,
-0.039650865,
-0.0036495258,
-0.0001929378,
0.00018232623,
0.033092692,
-0.01198444,
-0.04338271,
0.020895593,
-0.00029690986,
-0.0367971,
0.01872783,
0.013555381,
0.014076742,
0.014433463,
-0.004946068,
0.013143782,
0.031857893,
-0.004239487,
0.00002496133,
-0.010886838,
0.0156133855,
0.025327161,
-0.010482097,
0.000121658006,
-0.03084261,
0.004901478,
0.0071618515,
0.006815421,
-0.007038371,
0.0246,
-0.005508589,
0.008369214,
0.000639696,
-0.008691634,
-0.034162857,
-0.029525487,
0.003687256,
0.019866591,
-0.028812047,
0.00045318948,
-0.005028388,
0.0005878172,
-0.010461517,
0.013527942,
-0.016162187,
-0.015366425,
-0.009898996,
-0.0016086726,
0.024366759,
0.0003800875,
-0.00046133573,
0.020429114,
0.017108867,
0.0372087,
0.0030407,
-0.012622421,
-0.0072716116,
0.0065821805,
0.014323703,
0.008959174,
0.026507083,
0.014584384,
-0.0032962353,
-0.001227942,
-0.010413497,
-0.012176519,
-0.010605577,
0.028263245,
-0.032708533,
0.015188064,
-0.015311545,
-0.0072990516,
-0.010955438,
0.0027474344,
-0.026918683,
-0.01182666,
-0.013521082,
-0.013548522,
0.020511433,
0.013809202,
-0.017685108,
-0.017383268,
0.027728165,
-0.01929035,
-0.007470552,
-0.0008244876,
0.0026565392,
0.024010038,
0.015750585,
0.009857836,
-0.6300234,
-0.004592777,
0.0070177913,
-0.006626771,
0.011956999,
0.039842945,
-0.003618656,
-0.017232347,
-0.014172783,
0.010440937,
-0.013356442,
-0.00048363078,
0.009199275,
-0.016820747,
-0.027398884,
-0.027549805,
-0.01258812,
-0.012732181,
0.022583157,
0.0114013385,
-0.010118516,
-0.0027405745,
-0.021499274,
0.023378918,
-0.013411322,
0.017026547,
0.03701662,
0.0046339375,
0.011264138,
0.03572694,
-0.009329615,
0.0039993864,
0.0023975738,
-0.0026085193,
0.045358393,
0.013555381,
-0.02505276,
0.031391412,
0.0016464026,
0.03150117,
-0.027659565,
-0.01215594,
0.019551031,
0.0058824597,
-0.02440792,
0.010831958,
-0.0051587285,
-0.012011879,
-0.005686949,
-0.03199509,
0.017383268,
0.01238918,
-0.016162187,
0.0036632458,
0.009809816,
0.0012965421,
0.033559173,
-0.014995984,
0.0025776492,
-0.01861807,
-0.013404462,
0.009171835,
-0.009151255,
-0.008039933,
0.016477747,
-0.0038621863,
-0.014255103,
-0.0127184605,
0.0059544896,
0.0025776492,
0.014776464,
0.032681093,
0.016011266,
0.014831344,
0.022363637,
0.027165644,
-0.004366397,
-0.0038759063,
0.01911199,
0.009137535,
0.0146667035,
0.0100842165,
-0.042943668,
0.0013085471,
0.021266034,
-0.003642666,
-0.013232961,
0.017945789,
0.006952621,
0.010742777,
0.0038004462,
-0.0020185583,
-0.01817903,
-0.04417847,
-0.010633017,
0.029580368,
0.017904628,
0.026205242,
0.013932683,
-0.03531534,
-0.038251422,
0.015723145,
0.013713162,
0.010756497,
0.03097981,
0.013136921,
-0.032461572,
0.007292192,
0.01867295,
-0.016079865,
0.002526199,
-0.025972001,
0.001807613,
-0.017273508,
0.0048808977,
-0.03081517,
0.015174344,
0.0011842094,
-0.005539459,
-0.012889961,
0.015846625,
-0.022240156,
0.01854947,
-0.010310597,
0.01819275,
0.03303781,
0.0046407976,
0.017040268,
0.0029498048,
0.0005582334,
-0.030568209,
-0.014241383,
0.01865923,
-0.0362483,
0.011380758,
0.00087550894,
0.0069732014,
-0.010756497,
0.017959509,
-0.0373459,
-0.0246,
-0.02409236,
0.0016952802,
-0.026548242,
-0.040611267,
-0.016477747,
-0.011236698,
0.030019408,
0.028537646,
0.0065787504,
-0.009315895,
-0.012745901,
-0.019962633,
0.009151255,
0.023159398,
0.0027594394,
-0.022185275,
-0.012732181,
-0.0025742191,
0.0005046396,
-0.0052856384,
0.017822308,
-0.026781483,
-0.01275962,
-0.015942665,
-0.014076742,
-0.009357055,
0.011367038,
0.013857222,
-0.017918348,
-0.0066370605,
-0.015627105,
-0.026946124,
0.0152429445,
-0.013582822,
-0.008869994,
0.009782376,
-0.015970105,
-0.009514836,
0.0016223926,
0.010427217,
-0.010488957,
-0.013527942,
-0.013425042,
0.05394713,
0.004867178,
0.021183714,
0.0065581705,
0.026081761,
0.04461751,
-0.007367652,
0.0385807,
-0.013150642,
0.021595314,
0.0044452874,
-0.023159398,
0.02550552,
0.013253542,
-0.012931121,
0.0248058,
0.022514556,
-0.009466816,
0.009062075,
-0.0016069576,
-0.0018727831,
-0.026877522,
-0.0022792388,
-0.023570998,
-0.009569716,
0.01867295,
-0.0010744493,
0.011291578,
-0.00047934326,
-0.021073954,
0.0067536808,
0.022020636,
-0.0013900098,
0.020758394,
-0.011017178,
-0.0041297264,
-0.0062186,
-0.014172783,
0.007882153,
0.007909593,
0.0065341606,
0.019935193,
-0.0028606246,
0.016930507,
0.008218293,
-0.012670441,
-0.0009346765,
0.029415727,
0.0051621585,
-0.026328722,
0.006743391,
0.016971668,
0.00627691,
-0.0019002231,
0.035864137,
-0.008794534,
0.011902119,
0.02520368,
0.010118516,
0.00048663202,
0.021705074,
-0.0011567693,
0.053151365,
0.01918059,
-0.027440045,
-0.009974456,
-0.01244406,
0.010187116,
-0.016271947,
0.002404434,
0.017698828,
-0.0071687116,
0.0046373676,
0.0068325712,
0.042120468,
-0.0011327594,
-0.0020305633,
0.020374233,
0.0055154487,
0.0081908535,
0.01853575,
0.0046648076,
-0.016532626,
0.008760234,
-0.0134524815,
-0.014735304,
-0.019674512,
0.0044692974,
0.0008978039,
-0.023667037,
-0.010283156,
-0.013308422,
0.011367038,
0.02472348,
-0.004349247,
0.014159063,
0.008513274,
-0.029141327,
0.02509392,
0.018137868,
-0.029882208,
-0.014680424,
-0.0069766315,
-0.023227997,
-0.0003590787,
0.0067228107,
0.01205304,
0.0035603459,
-0.006901171,
-0.0003957369,
-0.0038278862,
0.0010084216,
-0.0071755718,
-0.0038244561,
0.020278193,
0.004356107,
0.028592527,
0.024051199,
0.0041331565,
-0.012931121,
0.017328387,
-0.00306128,
-0.03073285,
-0.013466202,
-0.012883101,
-0.020072393,
-0.001234802,
-0.028373007,
0.005717819,
-0.03237925,
0.026836364,
-0.0048568877,
0.01843971,
-0.0009140965,
0.034739096,
0.011133798,
-0.024133518,
-0.022500837,
-0.019139431,
0.003721556,
0.0115591185,
0.033339653,
-0.008033073,
0.026013162,
-0.033998214,
-0.01896107,
-0.011785499,
-0.002485039,
0.025601562,
-0.0146667035,
0.01839855,
0.0064587006,
-0.013617122,
-0.0007503137,
-0.016436586,
0.0033099554,
0.008506414,
-0.02539576,
-0.0053851088,
0.0024953291,
-0.010125376,
-0.005553179,
0.01897479,
0.04409615,
0.00045790573,
0.004338957,
0.0016969952,
0.00616715,
-0.0013299846,
-0.014323703,
-0.0066473507,
0.009576576,
-0.014598103,
0.011908979,
0.022802677,
-0.016642386,
0.0044109873,
0.0058241496,
-0.014419743,
0.0071412716,
0.028235806,
0.014460904,
0.014735304,
-0.0060471,
-0.008520134,
-0.016820747,
-0.0008703639,
0.020854434,
-0.010180256,
0.00056938094,
0.024147239,
-0.015160625,
-0.008458394,
-0.025368322,
0.009919576,
-0.004448717,
0.012080479,
-0.0035157558,
0.00040302565,
-0.021897156,
-0.0017698829,
-0.02531344,
0.025999442,
-0.01883759,
0.0041948967,
0.009761795,
-0.013534802,
-0.005169018,
-0.029799888,
-0.013274121,
-0.016230786,
-0.013706302,
-0.06431946,
-0.021320915,
0.011668879,
0.027618404,
0.010996598,
0.009110095,
-0.0156133855,
0.022130396,
-0.004973508,
-0.020730954,
-0.006733101,
-0.016724708,
0.00617058,
0.002471319,
-0.004098857,
-0.013164361,
-0.015407585,
0.0078066927,
0.013610262,
0.012231399,
0.007902733,
-0.017300949,
-0.0366599,
0.011819799,
0.01787719,
0.017493028,
0.010235136,
-0.0065032905,
-0.011675739,
-0.014899944,
-0.039705746,
-0.021924596,
-0.028345566,
-0.014872504,
0.004349247,
0.0039890963,
-0.008760234,
-0.013706302,
-0.007930173,
-0.010372337,
0.003711266,
0.012567541,
0.020415394,
0.028126046,
0.010509537,
0.013342721,
0.007937033,
-0.0028177495,
0.010914277,
-0.0059098997,
0.021801116,
0.0020374232,
-0.02479208,
0.010962298,
0.00021544722,
-0.009583435,
-0.01909827,
0.010516397,
0.0075803124,
0.03531534,
0.01907083,
-0.019880312,
-0.031226771,
0.0069148913,
-0.002997825,
0.0007267324,
-0.017150028,
-0.03106213,
0.010413497,
0.022308756,
0.022020636,
-0.026479643,
0.016889347,
-0.034382377,
-0.007065811,
0.011319018,
-0.0041125766,
0.021471834,
-0.019880312,
0.019715672,
-0.01941383,
-0.014502063,
0.0063420804,
-0.060203455,
-0.008108533,
-0.026164083,
0.01214222,
0.022884997,
0.019235471,
-0.0013925822,
0.013136921,
0.042943668,
0.009555995,
-0.0022020636,
0.0005955347,
0.01222454,
-0.033559173,
0.02516252,
0.006760541,
0.0046202173,
0.016381707,
0.016066145,
0.041297268,
0.034793977,
-0.0014894799,
-0.0067228107,
0.0031830452,
-0.0128145,
-0.024380479,
-0.0045584776,
0.00069543364,
0.0017338678,
-0.014035583,
-0.0028914947,
0.015640825,
0.016642386,
-0.010598717,
-0.0057281093,
0.012835081,
-0.026438482,
0.025258562,
-0.01857691,
0.032516453,
-0.03114445,
-0.016079865,
-0.011648299,
-0.0052273283,
0.011613999,
-0.0075528724,
0.010530117,
-0.007889013,
-0.016875627,
0.0011464794,
-0.013267261,
-0.019358952,
-0.0034059954,
-0.023310317,
-0.0005800997,
-0.0064141103,
-0.024023758,
-0.029552927,
-0.03676966,
0.00095611403,
0.00048320202,
-0.020237032,
0.026973564,
-0.015736865,
-0.014015002,
0.032982934,
-0.00624604,
0.0248744,
-0.01240976,
0.028084885,
0.00008215935,
0.0038381761,
-0.03904718,
-0.020278193,
-0.017122587,
0.005446849,
0.04401383,
-0.0047093974,
0.0011396194,
-0.027728165,
0.021595314,
0.013891523,
-0.0116620185,
-0.023461238,
-0.0016832752,
-0.003062995,
-0.029141327,
-0.0022329336,
-0.00004705539,
-0.004434997,
0.003766146,
-0.01857691,
0.019852873,
-0.011634579,
-0.011641439,
0.00021330347,
-0.009185554,
-0.014543223,
0.01846715,
-0.005772699,
-0.013171221,
-0.0044898773,
-0.015956385,
0.01849459,
0.015723145,
0.004877468,
0.026452202,
0.013445621,
0.016477747,
0.03043101,
0.0020168433,
-0.0121971,
-0.014749024,
-0.0034557306,
0.041461907,
0.011017178,
-0.026260123,
-0.01224512,
-0.005110708,
0.015270385,
-0.02477836,
-0.022432236,
-0.027247963,
-0.0378947,
0.010228276,
0.019029671,
0.010667318,
-0.009857836,
-0.0066988007,
-0.026877522,
-0.013294701,
-0.028400445,
-0.0038141662,
0.01227256,
-0.04914512,
0.005566899,
-0.008286893,
0.0046750978,
0.0019053681,
0.011641439,
-0.03114445,
-0.00035779245,
0.047443837,
-0.015366425,
0.017918348,
0.017630229,
0.019976351,
-0.01856319,
0.01258126,
-0.0009312465,
-0.009706915,
0.017232347,
-0.011593419,
-0.0057349694,
-0.0016155326,
-0.0014020148,
0.017410709,
0.0082937535,
-0.01929035,
0.0075528724,
-0.007422532,
0.021801116,
-0.004839738,
0.009528555,
0.015928946,
-0.0038141662,
0.011764919,
0.01841227,
-0.0030063998,
0.0071412716,
-0.0054571386,
-0.01199816,
0.0060093696,
-0.03032125,
0.001835053,
0.005086698,
0.03065053,
-0.0017887478,
0.001563225,
-0.009130674,
0.003762716,
-0.024915561,
0.01857691,
-0.0010427217,
-0.01911199,
-0.0013702873,
-0.00621174,
-0.0014260248,
0.0013334147,
-0.0070726713,
-0.01221082,
0.010276296,
-0.020593753,
-0.02455884,
-0.011346458,
-0.045276072,
0.03792214,
0.012910541,
0.0009895565,
-0.0007614612,
-0.007264752,
-0.015448745,
-0.03177557,
0.001992833,
0.00069071737,
0.002500474,
-0.0034094255,
0.0033253904,
-0.00300983,
-0.0120942,
0.026287563,
0.011867819,
-0.010729058,
0.017589068,
-0.008170273,
0.017739989,
0.015105745,
-0.0348763,
-0.021238593,
0.03150117,
-0.023598438,
0.008595594,
0.013006581,
-0.04330039,
0.032955494,
-0.01222454,
0.005086698,
0.00089523144,
0.029745009,
0.007497992,
-0.017396988,
0.0029532348,
-0.0038107361,
-0.00604367,
-0.0019602482,
0.00084463885,
-0.008540714,
0.027055884,
0.0027097045,
-0.026548242,
-0.00052907836,
0.004788288,
-0.009309035,
0.019509872,
0.038525824,
0.030485889,
0.0074911322,
0.020387953,
0.013020301,
-0.009274735,
-0.009075794,
-0.016134746,
0.0072784717,
-0.009459956,
0.00096125907,
-0.0045824875,
-0.0017784579,
0.004843168,
-0.017287228,
0.015956385,
-0.01828879,
0.01861807,
-0.016175905,
0.035644617,
-0.008046793,
-0.009096375,
-0.017643949,
-0.0033236754,
-0.021691356,
-0.012080479,
-0.009693196,
0.00301326,
-0.00594077,
0.0035329056,
-0.014556943,
-0.0075185723,
0.010097937,
0.0029275098,
-0.014625544,
-0.03191277,
0.016971668,
0.1741894,
-0.028030004,
0.0041468767,
-0.008492693,
0.015009704,
0.014543223,
0.014886224,
0.0017184328,
0.00305442,
0.00614314,
0.0044624372,
0.001231372,
-0.013623982,
0.000043866556,
0.013987563,
-0.015366425,
-0.025286,
-0.0041057165,
-0.010372337,
-0.019372672,
0.0065032905,
-0.020415394,
-0.000017511786,
-0.023022197,
0.04969392,
0.01255382,
-0.040117346,
0.00613971,
0.012128499,
0.010681037,
-0.02396888,
0.009020914,
0.011806079,
0.008959174,
0.018055549,
-0.007813552,
-0.006685081,
-0.017822308,
0.013404462,
0.021897156,
0.0051484383,
0.0143511435,
0.020442832,
-0.011497378,
0.0065616006,
0.01919431,
-0.0035912157,
-0.015009704,
-0.0034059954,
0.0065032905,
-0.024023758,
0.033531733,
0.017342107,
0.0130889015,
-0.008012493,
0.015256665,
-0.0051998883,
0.002529629,
0.0053439485,
0.0359739,
-0.028427886,
0.008636754,
-0.033120133,
0.019153152,
-0.004311517,
0.020168433,
-0.016532626,
0.016340546,
0.0035260457,
-0.047498718,
0.0027199944,
-0.014954824,
-0.03032125,
0.011106358,
-0.021787396,
-0.02553296,
0.029086446,
0.013466202,
0.027920244,
0.04217535,
-0.011593419,
0.005669799,
-0.021471834,
-0.011812939,
-0.009905856,
-0.014063023,
0.035836697,
-0.00031341676,
-0.0247372,
-0.010509537,
0.014063023,
-0.010063636,
-0.0060608196,
-0.00077946874,
0.01198444,
-0.013617122,
-0.008142834,
0.0041400166,
-0.010392916,
-0.017300949,
-0.020483993,
0.07310028,
0.040172227,
0.01898851,
0.007669492,
0.012725321,
-0.002558784,
0.008060513,
0.009892136,
-0.020003792,
0.0011713469,
0.0048225876,
0.0045481874,
0.0003704406,
-0.0057864194,
0.014282543,
0.01198444,
-0.007964473,
0.017136307,
-0.008417234,
0.010070496,
-0.018055549,
0.002438734,
0.019811712,
-0.017342107,
0.005525739,
-0.01235488,
-0.006842861,
-0.008835694,
-0.016340546,
0.0005333659,
-0.02396888,
-0.013322142,
0.00619116,
-0.0015040574,
-0.046209034,
0.020250753,
-0.021211155,
-0.03259877,
0.0102419965,
-0.007559732,
0.015023424,
-0.0034282906,
-0.010626157,
0.025862241,
-0.027467484,
0.021293474,
0.03087005,
-0.03158349,
-0.0064792805,
-0.0037592861,
-0.0072784717,
0.01221768,
-0.0065856106,
0.018371109,
-0.020730954,
-0.020291913,
-0.01275276,
0.017108867,
0.014447183,
-0.013521082,
0.0066370605,
0.0060951198,
-0.021087674,
0.013075181,
-0.014817624,
-0.17396988,
0.0017098577,
0.022020636,
-0.014104183,
0.023941439,
0.023529839,
-0.009357055,
0.008787674,
-0.009130674,
0.009796096,
0.03655014,
0.035397656,
-0.028866926,
-0.01930407,
-0.0027079894,
0.017081428,
0.0020031233,
0.04236743,
-0.010687897,
0.020250753,
0.0119913,
-0.030376129,
0.025807362,
-0.00054494216,
-0.0028280395,
0.007014361,
0.015681986,
0.009302175,
0.00045276072,
-0.031857893,
-0.027892806,
0.004956358,
0.013802342,
0.011113218,
0.010290016,
0.016395427,
-0.001272532,
-0.019660791,
-0.013870942,
0.039760623,
0.01839855,
0.0377575,
-0.004201757,
0.0017304377,
-0.013109481,
0.035233017,
-0.005748689,
-0.0060059396,
0.013157501,
-0.010159676,
0.03303781,
-0.028565086,
-0.0066645006,
0.0041674566,
0.03136397,
0.020237032,
-0.004887758,
0.018028108,
0.011572839,
-0.018151589,
0.012512661,
0.0006032522,
0.026699163,
0.0016549777,
-0.007840993,
-0.017424429,
-0.016656106,
0.008245734,
-0.030019408,
-0.016738428,
-0.008526994,
-0.009336475,
0.010207697,
-0.023474958,
0.042943668,
-0.007559732,
-0.00050378207,
0.0042189066,
0.0026719742,
0.0040096766,
0.0016712702,
0.014474624,
-0.029470608,
0.006818851,
0.000087786706,
0.0008978039,
0.0032550753,
0.034793977,
0.0039410763,
-0.01754791,
0.015188064,
-0.007374512,
0.03018405,
-0.009988176,
0.013425042,
-0.0017561628,
-0.019948913,
-0.009219855,
-0.02450396,
0.0067502507,
0.007532292,
0.004232627,
-0.00034600182,
0.039513662,
0.015709426,
0.020689793,
-0.03240669,
0.01237546,
0.045440715,
0.00017300091,
-0.004290937,
-0.013672002,
-0.013486782,
0.009905856,
-0.0007764675,
0.011963859,
0.008746514,
0.014172783,
0.015174344,
-0.04214791,
0.07342956,
0.0028760596,
-0.000791045,
0.0152429445,
-0.00067442487,
-0.052684885,
-0.14235894,
-0.03029381,
0.003748996,
0.013116341,
-0.03221461,
0.0062872004,
-0.029498048,
0.017616509,
0.0012673871,
0.03166581,
-0.036495257,
-0.02490184,
-0.004970078,
-0.023667037,
0.0014851924,
0.010248857,
0.016203346,
0.0029583797,
-0.011490518,
0.046236474,
-0.01797323,
-0.032900613,
0.010104796,
-0.003742136,
0.0026994143,
-0.0112435585,
-0.03018405,
-0.00629063,
-0.0093501955,
0.008753374,
0.008005633,
-0.033257335,
0.023927718,
-0.003821026,
0.0067262407,
-0.0023598438,
-0.0048568877,
-0.0250116,
0.01941383,
0.010248857,
-0.009048355,
0.0017784579,
0.027398884,
-0.015970105,
0.0029034996,
-0.0114013385,
-0.014858784,
0.029031567,
0.020237032,
-0.026328722,
-0.011250419,
-0.04398639,
-0.020799553,
-0.0008566439,
0.009219855,
-0.014460904,
0.020291913,
0.02584852,
-0.014296263,
0.020346792,
-0.0006148285,
0.010584997,
-0.017383268,
0.009446235,
0.019619633,
-0.009048355,
-0.037839822,
-0.051889125,
0.023694478,
-0.019551031,
-0.008876855,
0.027357724,
0.022034356,
0.013171221,
-0.01863179,
0.0053199385,
-0.021238593,
-0.0077861124,
-0.0050729783,
-0.011373898,
0.0023375489,
-0.026095482,
0.03550742,
-0.009219855,
0.020140992,
0.0006251185,
0.008108533,
-0.004994088,
0.009816675,
-0.010783938,
-0.0058241496,
0.026438482,
0.007882153,
-0.03032125,
-0.007813552,
0.004448717,
0.014968544,
-0.012773341,
0.0094530955,
0.021801116,
-0.0020459983,
-0.007319632,
-0.048239596,
0.02464116,
0.0033185303,
-0.013335861,
0.016230786,
-0.0040302565,
0.025258562,
-0.029745009,
-0.0066645006,
0.0042737867,
-0.013864082,
0.0014680424,
-0.0078204125,
-0.02464116,
-0.013569102,
-0.041242387,
0.0247372,
-0.009206135,
0.014392303,
0.028345566,
0.009967596,
-0.025231121,
0.0114013385,
0.004843168,
-0.014968544,
-0.01864551,
-0.01811043,
0.010097937,
-0.0022157836,
-0.011449358,
0.01275276,
-0.04277903,
-0.0038621863,
0.0077380924,
-0.03078773,
-0.00024824665,
0.008719075,
0.026548242,
0.036111098,
0.040062465,
-0.005542889,
-0.033614054,
0.009233575,
-0.028318126,
0.0023718488,
-0.01260184,
-0.039156944,
-0.015915226,
0.010008756,
-0.027398884,
0.029909648,
-0.0020305633,
0.008705354,
-0.0254232,
-0.0051621585,
-0.0123,
0.0012699595,
0.015778026,
-0.015407585,
-0.010605577,
0.021032793,
0.013946403,
0.013541662,
-0.0022157836,
0.0041297264,
-0.028235806,
-0.021979475,
0.0035191856,
-0.012848801,
-0.030156609,
-0.017355828,
-0.019015951,
0.010077356,
0.012238259,
-0.005673229,
0.005666369,
-0.0076008923,
-0.0065032905,
-0.032461572,
0.016985387,
0.010626157,
0.0051038484,
-0.01908455,
0.011963859,
0.02506648,
0.0063901003,
-0.03188533,
0.026136642,
-0.01872783,
0.0060916897,
0.00153407,
0.0054056887,
0.015352705,
0.016916787,
0.008849414,
0.01856319,
0.0021969185,
0.01882387,
-0.022459676,
0.023721918,
-0.0056217792,
0.011476799,
0.012903681,
-0.019331511,
-0.0028760596,
0.03191277,
-0.02529972,
-0.022089235,
-0.005604629,
-0.0016215352,
-0.0241884,
0.003718126,
-0.0050764084,
0.007532292,
-0.022061795,
0.027247963,
-0.0072784717,
-0.03029381,
-0.008773955,
0.030046849,
0.040117346,
-0.011689459,
-0.0033905604,
-0.014186503,
0.0065616006,
-0.011847239,
0.05103848,
-0.007614612,
0.0020768684,
-0.010392916,
0.004263497,
0.022761516,
-0.0139807025,
-0.022884997,
0.014474624,
-0.015476185,
-0.0073333518,
0.015585945,
-0.021375794,
0.08703982,
0.010879978,
-0.008897434,
0.01242348,
-0.028180925,
0.022185275,
-0.005539459,
0.029443167,
-0.008266313,
-0.044919353,
0.03078773,
-0.02455884,
0.0041640266,
-0.01898851,
-0.003711266,
0.029388288,
-0.009178695,
0.008657334,
0.010180256,
-0.019990072,
0.0067502507,
-0.013068321,
0.008904294,
0.020127272,
-0.02468232,
-0.013768042,
0.012835081,
0.0066953707,
-0.013335861,
0.008163413,
-0.015078304,
0.0045721973,
-0.046126716,
0.0038244561,
-0.0023615588,
0.01225884,
-0.020456553,
-0.023639599,
-0.0026479643,
0.017794868,
0.015338984,
0.00020976628,
-0.0030184048,
-0.033257335,
-0.008684774,
-0.01230686,
0.004729978,
0.0040062466,
-0.035836697
] |
Mycobacterium tuberculosis (Mtb) infects lung macrophages, which instead of killing the pathogen can be manipulated by the bacilli, creating an environment suitable for intracellular replication and spread to adjacent cells. The role of host cell death during Mtb infection is debated because the bacilli have been shown to be both anti-apoptotic, keeping the host cell alive to avoid the antimicrobial effects of apoptosis, and pro-necrotic, killing the host macrophage to allow infection of neighboring cells. Since mycobacteria activate the NLRP3 inflammasome in macrophages, we investigated | [
-0.02936499,
-0.013273238,
-0.0043752524,
-0.029050365,
-0.008612856,
0.01092666,
-0.020267088,
-0.0013707486,
-0.0093666455,
0.005420725,
0.013594418,
-0.0032134345,
0.030492397,
0.00087095384,
0.0032429306,
0.012099949,
0.041504268,
0.006459642,
0.009727153,
-0.01915279,
-0.016281838,
0.012630879,
-0.0102122,
-0.012545668,
0.0036181863,
0.009281434,
-0.0067021656,
-0.030938115,
-0.01478737,
-0.0057189628,
-0.011614902,
-0.010782457,
-0.006148295,
-0.0039098696,
0.006233506,
-0.01667512,
0.032616112,
-0.007839404,
0.016911088,
0.0106054805,
-0.006072916,
0.01915279,
-0.011254394,
0.016072089,
0.0019008587,
0.004666936,
0.0012314615,
-0.0071970443,
-0.02752968,
-0.0148398075,
0.021132305,
-0.018300682,
-0.024173679,
-0.00084145775,
-0.0037656666,
-0.0069479663,
-0.029286334,
0.01961162,
0.019467415,
-0.019965572,
-0.023374008,
-0.014761152,
-0.027896741,
0.018431775,
-0.013365003,
0.027424803,
-0.00009376273,
0.013260128,
0.009936903,
0.016150745,
0.042185955,
0.033061832,
0.0055157677,
0.012263816,
-0.00069725467,
-0.030177772,
-0.030780802,
0.02063415,
0.001501023,
0.022639884,
0.022836523,
-0.0037722215,
-0.01313559,
0.044545643,
0.02309871,
-0.019205227,
-0.003824659,
0.0030593993,
0.011333051,
-0.02018843,
-0.0020532552,
0.004555506,
0.03390083,
0.031750895,
-0.023177367,
0.018562868,
0.0020581712,
0.030702146,
-0.004650549,
-0.024121242,
-0.00546333,
-0.0162294,
-0.025576383,
-0.0200049,
-0.019034807,
0.02372796,
-0.00028123698,
-0.0055878693,
0.020070447,
-0.018012276,
-0.015167542,
0.044414546,
-0.009641943,
-0.052463703,
0.013076597,
0.008147473,
0.006816873,
-0.0045751706,
0.004542397,
-0.004889795,
0.0026153193,
0.021774665,
0.009281434,
-0.030099114,
0.015914775,
-0.007662427,
-0.0013445298,
-0.00947152,
0.0028709522,
0.002402292,
0.022600556,
0.025065117,
-0.0022105677,
0.006515357,
-0.0004715277,
0.0018123705,
-0.019939354,
-0.014630058,
-0.031514928,
-0.018864384,
0.008009826,
0.037754986,
-0.0016296586,
-0.02499957,
-0.005699299,
0.02270543,
0.027975397,
0.02127651,
0.0078066303,
0.020503055,
0.01082834,
-0.031174084,
0.006784099,
-0.03922324,
-0.0019860696,
-0.0014887329,
-0.020463727,
0.01898237,
-0.01789429,
-0.015324854,
-0.016124526,
-0.00028820132,
0.030256428,
0.003614909,
0.038829956,
0.029076584,
0.027582116,
0.015613261,
0.0041163424,
-0.0017730424,
0.009235552,
0.024514522,
-0.009956567,
0.021879539,
0.0023596867,
0.015993433,
-0.011070863,
0.017212603,
-0.0137124015,
0.008095036,
-0.0011552633,
0.01646537,
0.020725915,
0.01186398,
-0.027162615,
0.011260949,
0.016098307,
-0.019585399,
0.007629654,
-0.023636196,
-0.0030102392,
0.0072757006,
-0.0072757006,
-0.011595238,
-0.63680077,
-0.012512894,
0.017133947,
0.00065669755,
-0.016085198,
0.0046866,
0.010651364,
-0.016111417,
-0.024527632,
0.021394493,
-0.0028037666,
0.016491588,
0.042500578,
-0.026507147,
-0.00025296988,
-0.02334779,
-0.014040136,
0.0043949164,
-0.0060565295,
-0.012126168,
0.0025891007,
0.012231043,
-0.018379338,
0.011385488,
-0.025038898,
0.028132709,
0.03211796,
-0.00770831,
-0.0018680854,
0.04100611,
-0.019231446,
0.016176963,
0.012113059,
-0.0041458383,
0.05825804,
-0.01646537,
-0.021158524,
0.032249052,
0.010684137,
0.005797619,
-0.019755822,
-0.004902905,
0.013365003,
-0.013115926,
-0.005679635,
0.03211796,
0.0075313332,
0.023256024,
0.003310116,
-0.008671849,
0.009864802,
0.021538695,
-0.011968856,
0.017042182,
0.013555089,
0.025248649,
0.017527228,
-0.0053387913,
0.023229804,
0.0021073313,
-0.0141187925,
0.01010077,
0.009045466,
-0.00916345,
-0.036522705,
0.003236376,
-0.017448572,
0.010657919,
0.006472752,
-0.0037099519,
0.024134351,
0.010028669,
-0.033874612,
0.005689467,
0.013659964,
0.046983983,
-0.023544429,
-0.0032199891,
-0.016360495,
0.008868489,
-0.010048333,
-0.021171633,
-0.020096665,
-0.008042599,
0.020870117,
0.00458828,
-0.014682495,
0.002721833,
0.007374021,
0.020450618,
0.012532558,
0.005410893,
-0.010041778,
-0.035893455,
-0.0007681272,
0.026716897,
-0.0023514933,
-0.02166979,
-0.022036852,
-0.0068562008,
-0.0043097055,
0.0016739027,
0.008475208,
0.00299713,
0.028866835,
-0.0073871305,
-0.039092142,
-0.010303966,
0.039275676,
-0.035526395,
-0.0027414972,
-0.018431775,
0.009753372,
-0.0151544325,
0.02523554,
-0.020581711,
0.04585658,
-0.0044834046,
0.025130663,
-0.032852083,
0.02523554,
0.008993029,
0.009124122,
-0.012689871,
-0.006541576,
0.012106503,
0.035657488,
-0.024016367,
-0.018877493,
-0.0064432556,
-0.012204824,
-0.004601389,
0.03723061,
-0.014630058,
0.027136397,
0.017186385,
0.0035821355,
0.007452677,
0.0045194556,
-0.031934425,
-0.04187133,
-0.028473552,
0.013319121,
0.01000245,
-0.0029741884,
-0.014957792,
-0.019886915,
-0.0061351852,
0.009936903,
0.009838583,
0.008081927,
0.006571072,
0.0125653315,
0.014302324,
0.03080702,
-0.018549759,
-0.0131945815,
-0.009012693,
-0.011313387,
0.008684958,
-0.0005600159,
-0.0067251073,
0.0055255997,
0.01457762,
-0.005165092,
-0.013391222,
0.011090527,
0.007845959,
0.028788177,
-0.0324588,
0.011333051,
-0.022115508,
-0.0033920496,
-0.002362964,
-0.0018205638,
-0.0055452636,
-0.01708151,
-0.0040212995,
-0.0016911088,
-0.00656124,
0.007996717,
-0.006764435,
0.025694367,
0.002033591,
-0.000575993,
0.031698458,
0.011634567,
-0.030911896,
0.0038803737,
0.03668002,
-0.0012527643,
0.0042998735,
-0.016911088,
0.003644405,
0.03023021,
0.000027447744,
0.005030721,
0.021119196,
0.007944278,
0.018864384,
-0.032825865,
-0.02458007,
0.021774665,
-0.020765243,
0.00032445692,
-0.014145011,
-0.0072625913,
-0.02582546,
0.038856175,
-0.004178612,
0.008966809,
-0.00011306832,
-0.011483809,
-0.016701339,
0.01333223,
0.015665699,
0.02104054,
-0.009530513,
-0.018798837,
-0.026559586,
-0.013351894,
-0.00091765594,
0.0123818,
-0.006148295,
-0.021958197,
0.013017605,
-0.0062302286,
0.03185577,
-0.025773022,
-0.018995479,
0.005453498,
-0.0005718963,
0.0065382984,
-0.002049978,
0.0070725055,
-0.0021614074,
-0.01249323,
0.003126585,
0.040271986,
0.0030905341,
-0.01892993,
0.010992208,
0.00094469404,
0.0048865178,
-0.010428504,
0.019624729,
0.005738627,
0.0047750883,
0.0007943459,
-0.018654635,
-0.0055813147,
-0.0005210975,
-0.038620207,
-0.012014738,
-0.0068234275,
-0.025563274,
-0.00473576,
0.006446533,
0.05348623,
0.0035264208,
-0.006380986,
-0.029102802,
0.000410692,
-0.04255302,
0.021315837,
-0.007518224,
-0.013312566,
-0.024239227,
-0.013266684,
0.00006769761,
-0.02540596,
-0.00073412474,
0.024317883,
-0.02849977,
0.025458397,
0.013673074,
0.005633752,
0.0024350656,
0.011772214,
-0.008121255,
-0.019192118,
-0.0134895425,
0.031174084,
0.011955746,
-0.00072511204,
-0.017396135,
-0.030466177,
0.007859068,
-0.012539113,
0.021945087,
0.022364587,
0.01456451,
0.0020172044,
0.008894708,
-0.010546489,
-0.011005317,
0.022731649,
-0.0026743116,
0.03515933,
0.005968041,
-0.0015395317,
-0.006571072,
-0.0019451028,
-0.005050385,
0.008376888,
-0.005682912,
-0.00080417795,
0.0015878725,
-0.018379338,
-0.0153772915,
-0.0037066746,
-0.0029578018,
0.0037460027,
-0.0109201055,
0.0030446514,
0.024973352,
-0.020974994,
0.017750088,
0.023400227,
-0.005951654,
-0.0012830796,
-0.034031928,
-0.000714051,
-0.027031522,
0.036758676,
0.025851678,
-0.015901666,
0.005443666,
-0.001964767,
0.019192118,
0.018693963,
-0.024081914,
0.036758676,
-0.018641526,
-0.004312983,
-0.0034608738,
0.008907817,
0.017422354,
0.027241273,
0.01354198,
0.007911505,
-0.025917226,
-0.022430133,
-0.011405152,
0.0056665256,
0.00022203996,
0.027555898,
0.018510431,
0.035683706,
0.00010282663,
-0.016006542,
-0.008927481,
0.01031052,
-0.025143772,
-0.0014076186,
0.00092994596,
0.0009094626,
0.009956567,
0.0024858643,
-0.009497739,
0.00054240023,
0.009432192,
-0.007459232,
0.011215067,
0.010081106,
0.007065951,
0.00677099,
-0.0012117975,
0.025169991,
0.008665294,
0.0028152373,
0.021171633,
-0.0048734085,
0.0042244946,
0.054534983,
-0.011759105,
-0.036470268,
-0.026598914,
0.016190073,
-0.0055452636,
-0.0010954518,
0.008140919,
0.011451035,
0.008344115,
-0.008888153,
-0.037833642,
0.019585399,
0.005309295,
0.0055223224,
0.008265458,
-0.015337964,
-0.011306833,
-0.02855221,
0.014328542,
-0.001298647,
-0.030544834,
-0.017514119,
0.017251931,
0.0035165886,
0.0047554243,
0.010572707,
-0.020267088,
-0.01667512,
0.026100757,
-0.0072560366,
0.0032937294,
-0.014197448,
-0.052804545,
0.013109371,
-0.026336726,
0.0082195755,
-0.017107729,
-0.033009395,
0.009753372,
0.009458411,
-0.0096616065,
-0.010192536,
0.012440793,
-0.0133977765,
0.016963525,
0.0052863536,
0.008809497,
-0.011057754,
-0.02312493,
-0.0049946704,
-0.0264416,
-0.014957792,
-0.015613261,
-0.00029250284,
-0.030308865,
0.0066497284,
0.0077804113,
-0.016072089,
-0.0019860696,
0.019244555,
-0.0042015533,
-0.0047128187,
-0.002013927,
0.012375246,
0.030571053,
0.005387951,
0.021630462,
0.01312248,
0.0020958607,
-0.015914775,
-0.0073609115,
0.012224488,
0.0022351476,
-0.016032761,
-0.01583612,
0.007164271,
-0.014813589,
-0.01542973,
-0.006790654,
-0.016085198,
0.008022935,
0.028290022,
-0.02894549,
-0.036312956,
-0.00077713985,
0.0106317,
0.0035985222,
-0.011483809,
-0.01772387,
-0.0074920054,
0.005486272,
-0.0036411276,
0.004879963,
0.023990149,
-0.035552613,
0.003991803,
0.029233897,
0.006027033,
0.009078239,
-0.0153772915,
-0.0069676307,
-0.03327158,
-0.0051421504,
-0.035133112,
-0.033769738,
-0.01789429,
-0.0052634124,
0.041740235,
0.0015002036,
0.009327318,
0.0049881157,
0.04124208,
-0.0077214194,
0.009523958,
-0.009196224,
0.0025284698,
0.0055878693,
-0.0048537445,
0.02752968,
0.024802929,
0.00045145396,
-0.006328549,
-0.003131501,
-0.008186802,
0.018811947,
-0.008154028,
-0.00325604,
-0.016714448,
-0.0023006946,
-0.04142561,
0.012637434,
-0.028394897,
-0.010998762,
-0.033166707,
-0.015547713,
0.032065522,
-0.002748052,
0.0072232634,
0.027424803,
-0.005060217,
-0.029889366,
0.012054066,
-0.0075575523,
0.009025802,
0.009635387,
0.0046374397,
-0.006685779,
-0.0043097055,
-0.020267088,
-0.0051421504,
-0.021079868,
0.012368691,
-0.027870523,
0.011870535,
0.0019254388,
-0.01605898,
-0.022810305,
-0.023845945,
-0.023413336,
-0.03515933,
-0.008619411,
-0.01478737,
-0.014289214,
0.012578441,
0.014013917,
0.008134364,
0.016439151,
-0.0150626665,
-0.01519376,
0.025471507,
0.003405159,
0.02059482,
-0.004814416,
0.013476433,
0.012408019,
-0.017841853,
-0.02270543,
-0.0055354317,
-0.020896336,
-0.010094215,
0.025104444,
0.023269134,
-0.030125333,
-0.007537888,
0.0048865178,
-0.0008406384,
0.018693963,
-0.017435463,
0.022587446,
-0.009596059,
0.0033019227,
-0.016911088,
-0.011503473,
-0.032825865,
-0.0060237558,
-0.026480928,
0.017160166,
0.012231043,
-0.013974589,
-0.0047587017,
-0.005161815,
0.009563286,
0.0033019227,
0.0074461224,
-0.029443646,
-0.0021450208,
-0.021551805,
-0.0044440767,
0.004371975,
-0.017999167,
0.026585804,
-0.0054043382,
0.024095023,
0.01666201,
0.008540755,
-0.006013924,
0.002980743,
-0.008475208,
0.03793852,
-0.008501427,
0.0058008963,
-0.018366229,
0.025720585,
0.007000404,
-0.027949179,
0.0037656666,
-0.015718136,
0.013050378,
-0.016163854,
0.013188027,
0.010848004,
-0.015613261,
-0.012303145,
-0.008291677,
-0.00980581,
0.012421128,
-0.024934024,
-0.006551408,
-0.032773428,
-0.006295775,
-0.007911505,
0.020227758,
0.021132305,
0.0068758647,
0.0029692724,
-0.02501268,
0.026087647,
-0.030020459,
0.0125849955,
0.004253991,
-0.011634567,
-0.0071708257,
0.01186398,
-0.014525183,
-0.036784895,
-0.010972544,
-0.005368287,
-0.013935261,
-0.02564193,
-0.01197541,
0.028263804,
0.004781643,
-0.031934425,
0.02729371,
0.0027890187,
0.0040311315,
0.00090864324,
-0.0032036025,
0.022010634,
-0.012532558,
-0.0036706238,
0.015128214,
-0.0038476002,
-0.032878302,
0.015770573,
-0.0030102392,
0.01135927,
-0.038803738,
-0.022246603,
-0.011837762,
0.002438343,
0.0069938493,
0.0060893027,
0.008684958,
0.0016960248,
-0.009982786,
-0.004866854,
-0.011726332,
-0.00077222387,
0.0012953697,
-0.016399823,
-0.0069086384,
-0.013725511,
-0.01540351,
0.013515761,
0.021971306,
-0.026520256,
-0.017815635,
-0.01312248,
-0.04082258,
0.03956408,
-0.019650947,
0.013476433,
-0.0039983583,
0.006580904,
-0.045332205,
-0.0104940515,
-0.0025055285,
0.006666115,
-0.006505525,
-0.0037033972,
-0.014459636,
0.009851692,
-0.006082748,
0.010775902,
-0.007983606,
-0.012709535,
0.011503473,
-0.01417123,
0.021722227,
-0.0011405152,
-0.017881181,
-0.004054073,
0.033586208,
0.0014838169,
-0.015600151,
0.005174924,
0.0010725104,
-0.022652993,
0.021984415,
-0.002538302,
-0.004312983,
0.020162212,
0.030439958,
-0.0012232681,
0.009727153,
0.038200706,
0.019441197,
-0.014066354,
-0.005214252,
0.030492397,
0.012997941,
0.012375246,
0.004804584,
-0.037623893,
0.02081768,
-0.033009395,
0.03644405,
0.02522243,
0.0007582952,
0.01895615,
0.0026857823,
-0.04019333,
0.0006087664,
0.018248243,
-0.004004913,
-0.03023021,
0.008455544,
0.008062263,
-0.0000042919105,
0.008075372,
0.008049154,
-0.00070626737,
-0.010559598,
-0.006915193,
-0.005594424,
-0.016072089,
0.006272834,
0.020961884,
-0.0068037636,
-0.015652588,
-0.0017042182,
-0.020345744,
-0.014669386,
0.005001225,
0.010022114,
-0.0067447713,
0.0070593962,
-0.012113059,
0.0017681264,
-0.0014666108,
-0.0069414116,
-0.016937306,
0.0033527215,
0.02249568,
0.19118707,
-0.014472745,
0.00093895866,
-0.0018369505,
-0.013155254,
0.0011331412,
-0.00843588,
-0.013895933,
-0.0049946704,
-0.0041851667,
0.02564193,
0.0021892649,
0.018471103,
0.0074461224,
0.0077738566,
-0.0128799565,
-0.02144693,
-0.007603435,
-0.025589492,
-0.025065117,
-0.012165496,
-0.0035788582,
-0.0032019638,
0.021315837,
0.034215458,
0.014512073,
-0.043260925,
-0.0005346165,
0.005224084,
-0.017186385,
-0.019414978,
0.00012085201,
-0.0090520205,
-0.004027854,
0.0015886918,
0.0069414116,
-0.026376054,
-0.026979085,
0.019336322,
0.0044145808,
0.0055616507,
0.022010634,
-0.00047972103,
0.006620232,
-0.0061712363,
0.018457994,
-0.011123301,
-0.010244973,
-0.016753776,
-0.0037656666,
-0.025943445,
-0.011510028,
-0.0014067993,
-0.0039000378,
0.0039950805,
-0.02831624,
0.012663652,
0.016793104,
-0.023675524,
0.015233088,
-0.015219979,
0.001884472,
-0.018707072,
0.031881988,
-0.009497739,
0.02834246,
-0.0075509977,
0.013935261,
0.021617353,
-0.023374008,
0.012237597,
-0.0023727962,
-0.017802525,
-0.021197852,
0.01519376,
-0.0028906162,
0.010703801,
0.0075313332,
0.01624251,
0.015573933,
0.0088488255,
-0.0054666074,
-0.021381384,
0.0062400606,
-0.019087244,
-0.029941803,
0.009543622,
0.0055157677,
-0.022652993,
-0.007662427,
0.017618993,
0.009740262,
0.0050995452,
0.006341658,
0.026808662,
-0.0001799466,
0.0063580447,
0.0007308474,
0.0022351476,
-0.01259155,
-0.025904117,
0.074408785,
-0.011831207,
-0.024501413,
-0.016321167,
0.010834895,
0.0033625537,
0.0032396533,
0.014302324,
-0.016334277,
0.023990149,
-0.022797195,
-0.015128214,
-0.008947145,
0.0093666455,
0.012722644,
0.007518224,
-0.014446527,
0.01731748,
-0.022954509,
-0.023177367,
-0.020122884,
0.0050929906,
0.021092977,
0.006197455,
-0.0021220795,
-0.026284289,
0.013273238,
-0.0040966785,
-0.021630462,
-0.008914372,
0.007996717,
-0.029496085,
0.009904129,
0.009425637,
0.033664864,
0.0043949164,
-0.027241273,
-0.021342056,
0.015914775,
-0.02897171,
0.011182293,
0.02269232,
0.0008009006,
-0.004630885,
-0.0069086384,
0.012755417,
0.009950012,
-0.0018713627,
-0.022456352,
0.0010397369,
-0.021132305,
-0.018615305,
-0.008934036,
0.022548117,
-0.014669386,
-0.011608347,
-0.005974596,
-0.0066530057,
0.0014108961,
-0.022770977,
-0.007151162,
0.0045686155,
-0.002148298,
0.004231049,
-0.008245794,
-0.16360494,
-0.00007635184,
0.018405557,
0.0044702953,
0.03796474,
0.0076558725,
-0.028866835,
0.004437522,
-0.0050471076,
0.022194164,
0.011981965,
0.019913133,
-0.030492397,
-0.012696425,
0.007544443,
-0.01541662,
0.030780802,
0.03877752,
0.027949179,
-0.0051323185,
0.041766454,
-0.03167224,
-0.001750101,
-0.006263002,
-0.011182293,
0.0018582533,
-0.007668982,
0.018444885,
0.0072560366,
-0.007295365,
-0.032668553,
0.0036968426,
0.018785728,
-0.004349034,
0.021355165,
0.02290207,
-0.0035559167,
-0.013391222,
0.00083572237,
0.014262996,
0.027739428,
0.012237597,
-0.007315029,
0.0044309674,
-0.014957792,
0.028919272,
-0.002743136,
-0.0065284665,
0.021879539,
-0.0106972465,
0.020437509,
-0.014354761,
0.005374842,
0.020267088,
0.003673901,
0.0049192915,
0.0025759914,
0.005374842,
-0.0016722641,
-0.0044506313,
-0.023374008,
-0.013174918,
0.015888557,
0.00046947933,
0.012611215,
-0.04292008,
-0.003854155,
-0.0011003678,
-0.01166734,
0.00833756,
-0.03335024,
0.0037132292,
0.012853738,
-0.0014879135,
0.002094222,
0.022403914,
-0.005886107,
-0.006295775,
0.0034477646,
0.022417024,
-0.0075313332,
0.016570244,
-0.031383835,
0.0019483803,
-0.010848004,
-0.003165913,
0.012571886,
0.017972948,
-0.011392043,
-0.0009692741,
0.016727557,
-0.009340427,
-0.017186385,
-0.007249482,
0.042002425,
0.040245768,
0.0061712363,
-0.016596463,
-0.014040136,
0.0013428911,
-0.0014584175,
-0.014498964,
-0.02541907,
0.01892993,
0.04666936,
-0.012670207,
-0.02041129,
-0.00749856,
0.05825804,
-0.018444885,
-0.00041294517,
-0.006557963,
0.018628417,
0.02604832,
0.013974589,
0.01583612,
0.02752968,
-0.012886511,
-0.0070921695,
-0.015010229,
0.06801142,
-0.008206466,
-0.039668955,
0.03542152,
-0.0024940579,
-0.030518616,
-0.13214245,
-0.005479717,
-0.0000205346,
0.021551805,
-0.029863147,
0.008068818,
0.0018271186,
0.009268325,
0.014603839,
0.007433013,
-0.027136397,
-0.01645226,
-0.0030282647,
0.0026267902,
0.00036808653,
-0.011490364,
0.023990149,
0.0054174475,
-0.016137635,
0.02144693,
0.00229414,
-0.00969438,
0.012211379,
-0.007085615,
0.026494037,
-0.01582301,
-0.0149315735,
0.026926648,
0.0014215474,
0.0073084743,
0.014918464,
-0.0009946735,
0.01898237,
-0.006426869,
-0.012447348,
0.0021958195,
0.017015964,
-0.016098307,
0.035841018,
-0.023767289,
-0.008324451,
0.03083324,
0.010939769,
0.016570244,
0.028054053,
-0.028997928,
-0.019047916,
0.01092666,
0.010939769,
-0.013502652,
0.0064235916,
-0.014695604,
-0.040560395,
-0.030072896,
0.023020055,
-0.023164257,
0.003434655,
0.031331398,
-0.019139681,
0.02831624,
0.014852917,
-0.00011163449,
0.008298231,
-0.005224084,
0.014944683,
-0.052830763,
-0.010723465,
-0.022836523,
0.030544834,
-0.033035614,
0.014682495,
-0.02375418,
-0.015757464,
-0.009025802,
-0.023452664,
-0.0054174475,
-0.009235552,
-0.011451035,
0.0046800454,
-0.009504294,
-0.019454306,
0.0003189264,
0.0062990524,
-0.030990552,
0.045305986,
0.007537888,
0.0032527626,
0.0054666074,
-0.0002544037,
-0.008599747,
-0.008776723,
0.023714852,
-0.02477671,
-0.0055419863,
-0.004801307,
0.010684137,
-0.014918464,
0.00060917606,
0.0106054805,
0.01667512,
-0.02705774,
-0.008081927,
-0.051965546,
0.02063415,
-0.0174879,
0.030571053,
-0.016740667,
-0.015573933,
0.017841853,
-0.016360495,
0.017854962,
0.056160543,
-0.001498565,
0.012316254,
-0.0033445281,
-0.00052396517,
-0.027634554,
-0.013922151,
0.01218516,
-0.006397373,
0.0011224899,
0.027188836,
-0.0030856181,
0.0023072492,
-0.0070921695,
0.018615305,
-0.0072232634,
0.0004944691,
0.0007296184,
0.028054053,
-0.021827102,
-0.029469864,
0.008468653,
-0.019467415,
0.0018893881,
0.0057910644,
-0.010762793,
-0.01301105,
-0.010769348,
0.01031052,
0.018615305,
0.051205203,
-0.0040409635,
-0.023623087,
0.008711177,
-0.013633746,
0.010172872,
0.009084794,
-0.005387951,
0.019965572,
0.0012257262,
-0.019126572,
0.03038752,
0.0035264208,
-0.021840211,
-0.030675927,
-0.020568602,
0.0018762787,
0.01541662,
-0.025523944,
-0.01436787,
-0.010585817,
0.03148871,
0.020725915,
0.007977052,
0.0349758,
0.0047881976,
-0.01663579,
-0.009871356,
0.015495276,
-0.0015395317,
-0.026808662,
-0.00770831,
-0.0014870942,
0.02831624,
-0.0030593993,
-0.0038672644,
0.0144334175,
-0.0012158941,
0.008331005,
-0.012834074,
0.013646855,
-0.0035624714,
-0.018877493,
-0.032983176,
-0.00060139236,
0.02146004,
-0.00015352303,
-0.01605898,
0.036391612,
0.006397373,
-0.01354198,
-0.018222025,
0.022049962,
0.015954103,
0.011804989,
0.01061859,
0.03515933,
0.00656124,
-0.006013924,
0.0050471076,
0.026113866,
-0.0038410455,
0.020739025,
-0.021197852,
-0.040350642,
0.00093732,
0.017579665,
-0.03083324,
-0.04166158,
-0.018667744,
0.0129913865,
0.01771076,
0.017409245,
-0.0027988506,
-0.0013101178,
-0.02041129,
0.026926648,
0.0031446102,
-0.0047390377,
-0.0076558725,
0.029076584,
0.023937711,
0.03392705,
-0.004332647,
-0.0017435463,
-0.003968862,
0.013096261,
0.025576383,
-0.049002826,
0.032380145,
-0.01727815,
0.023990149,
-0.00055346126,
-0.046983983,
0.0018008997,
-0.014013917,
-0.020371962,
0.037125736,
0.015010229,
-0.0021155246,
0.07126254,
-0.0015575571,
-0.017972948,
0.0030807022,
-0.017160166,
-0.002567798,
0.024907805,
0.016963525,
0.008514537,
-0.048006516,
-0.009379755,
0.0009807448,
0.008009826,
-0.04100611,
-0.043392017,
0.043024953,
-0.009720598,
0.0022466185,
0.014184339,
0.003988526,
0.019244555,
0.008861935,
0.011811543,
0.006646451,
-0.003121669,
0.010356403,
0.047587015,
0.011365824,
0.0039459206,
-0.028604647,
0.0036509598,
-0.00034391615,
-0.012499785,
-0.01187709,
0.012172051,
-0.018313792,
-0.013004496,
-0.027949179,
0.0057255174,
0.0075575523,
-0.013568198,
0.013856605,
-0.016478479,
-0.026572695,
0.006816873,
0.008357224,
0.00520442,
-0.010592371,
-0.014734932
] |
Conventional protocols for differentiating human induced-pluripotent stem cells (hiPSCs) into smooth-muscle cells (SMCs) can be inefficient and generally fail to yield cells with a specific SMC phenotype (i.e., contractile or synthetic SMCs). Here, we present two novel hiPSC-SMC differentiation protocols that yield SMCs with predominantly contractile or synthetic phenotypes. Flow cytometry analyses of smooth-muscle actin (SMA) expression indicated that ~45% of the cells obtained with each protocol assumed an SMC phenotype, and that the populations could be purified to ~95 | [
-0.027829167,
0.016278192,
-0.004072887,
-0.023622744,
-0.015637213,
0.023315607,
-0.025892876,
0.01752009,
-0.03650909,
-0.011791341,
0.005134508,
0.016718866,
0.0051211542,
-0.0041162865,
-0.012505765,
0.010896641,
0.027882582,
-0.009033796,
-0.023342315,
0.022901641,
-0.0300993,
0.0113974055,
-0.010369169,
-0.009340932,
-0.016331607,
0.013260251,
0.014675746,
-0.02407677,
-0.022848226,
-0.006039223,
0.008806783,
0.0017159539,
-0.0020781737,
-0.00086048077,
-0.026867699,
0.0025422159,
0.0031297798,
-0.004987617,
0.023622744,
-0.0049008178,
0.008826814,
0.010035326,
-0.0018177761,
0.006950615,
-0.0045803282,
-0.00485408,
-0.01266601,
-0.0057621333,
-0.0025338696,
0.01098344,
0.02716148,
-0.013500618,
-0.0068170778,
0.02450409,
-0.022020295,
-0.0060659307,
-0.0038024737,
0.008299341,
0.011103624,
-0.0045369286,
0.010930026,
0.013807754,
-0.022127125,
0.0041096094,
0.0010841558,
-0.0054316283,
-0.024263723,
-0.010082064,
0.011270545,
-0.0003428152,
0.01354068,
0.0033885082,
-0.006937261,
-0.028683806,
0.039713982,
-0.010576151,
-0.008272634,
-0.021526208,
-0.02722825,
0.000019235105,
-0.0014280141,
-0.02895088,
-0.0032349403,
0.014622331,
0.009340932,
0.009080535,
-0.008526355,
-0.00042126834,
-0.0100954175,
-0.012692718,
0.03250297,
0.037417144,
0.014034767,
-0.007952144,
-0.028283194,
0.017119478,
-0.008813459,
0.018241191,
0.0030496574,
0.004723881,
-0.003835858,
0.010415907,
-0.020017236,
-0.015663922,
-0.034025297,
0.0033284165,
0.018695218,
-0.0018060915,
0.01962998,
-0.011971616,
0.00926081,
0.014809283,
-0.026039768,
-0.038645685,
0.016652098,
-0.011263869,
-0.008285987,
0.0060058385,
-0.006519957,
-0.0062428676,
0.010355815,
0.01816107,
0.033437733,
-0.019937115,
0.028042827,
0.008900259,
-0.04238473,
0.00024600068,
-0.01605118,
0.0049442174,
0.016064534,
-0.022447616,
0.009628037,
0.026921114,
-0.014034767,
-0.004460145,
0.0027491986,
-0.0056152423,
-0.025532326,
-0.023729572,
-0.029778812,
0.01605118,
0.0076116244,
0.009507854,
-0.021592977,
-0.000090241985,
0.01705271,
-0.004460145,
0.007885376,
0.013286958,
0.017426614,
-0.0076116244,
0.010703012,
0.0048841257,
-0.01141076,
0.02855027,
-0.000241619,
0.01852162,
-0.018241191,
-0.022661274,
-0.023008471,
-0.006636802,
0.025291959,
-0.021512855,
0.011203777,
0.009367639,
0.012272075,
-0.009681452,
0.0241836,
-0.012332167,
-0.02250103,
0.009774928,
-0.023369022,
0.011230485,
-0.011130331,
-0.007177628,
-0.013053268,
-0.010475999,
-0.030286252,
-0.03787117,
0.010869934,
0.024277076,
0.02243426,
-0.013393789,
0.0131934825,
0.015290017,
0.010542767,
-0.018641803,
-0.003310055,
-0.028256487,
-0.019175952,
-0.0072577507,
-0.017106125,
-0.007892053,
-0.6337145,
-0.041049358,
0.0021365962,
-0.023769634,
0.025973,
0.033838343,
0.013807754,
-0.014528855,
-0.008452909,
0.004059533,
-0.007638332,
0.022781458,
0.017720396,
-0.025105007,
-0.0016366661,
-0.011003471,
0.013967998,
-0.017333137,
0.011350668,
-0.009521208,
-0.025559034,
0.0074513797,
-0.02561245,
0.025345374,
0.013313666,
0.004563636,
0.007998883,
0.008873551,
-0.00791876,
0.039313372,
-0.008553063,
0.040354963,
-0.006146053,
-0.013914583,
0.05496394,
0.024837932,
-0.030580034,
0.020297665,
0.010669628,
0.037069947,
-0.0059424085,
0.02113895,
0.016705513,
0.025692571,
-0.013660863,
0.01141076,
-0.0024721087,
-0.0025806078,
0.008579769,
0.007491441,
0.02561245,
0.0055718427,
-0.011437467,
0.014822637,
0.005358183,
-0.015530384,
0.024170246,
-0.00015148133,
0.0067002326,
0.024143538,
0.010082064,
0.025211837,
-0.02396994,
-0.0130666215,
0.013700924,
0.03589482,
0.0032766708,
-0.021045474,
-0.0071509206,
-0.011263869,
-0.003572122,
0.033704806,
-0.011924878,
0.008846845,
-0.017319784,
0.012278752,
-0.024383906,
-0.017373199,
0.007190982,
0.0008905267,
0.008673246,
0.0006439,
0.00019529826,
-0.026240073,
0.018481558,
0.017373199,
-0.04331949,
0.009681452,
-0.0058455938,
0.0110301785,
0.0062128217,
0.0025155083,
0.026427025,
-0.060786165,
-0.019549856,
0.0043232692,
0.0010849903,
0.010549445,
-0.018254545,
-0.033037122,
-0.013380434,
0.004934202,
0.016932527,
0.02863039,
0.026734162,
-0.0022016957,
-0.038351905,
0.006296282,
0.03378493,
-0.056139067,
0.022527738,
-0.00091389567,
0.013914583,
-0.007177628,
-0.0072577507,
-0.022100419,
0.022314077,
0.0026724145,
-0.0038926115,
-0.031087477,
0.010309077,
-0.014315195,
0.022193894,
0.025826108,
0.009093888,
0.017346492,
-0.0062829284,
-0.010228955,
-0.0028426747,
-0.014969528,
0.022687983,
-0.023769634,
0.024023354,
-0.029725397,
0.027962705,
-0.009000412,
0.010789812,
0.014969528,
-0.008586447,
-0.0031347873,
-0.027535385,
0.0024020015,
0.007958821,
-0.016011119,
-0.01074975,
-0.0180943,
-0.0163049,
-0.023916526,
0.020871876,
-0.010001942,
-0.029031003,
-0.0012652656,
0.009507854,
0.00058046984,
-0.0016783966,
-0.022047004,
-0.025158422,
-0.035707865,
0.015570446,
-0.03578799,
-0.0011300591,
0.040835697,
-0.0029111125,
0.021953527,
0.004183055,
-0.008159127,
-0.02895088,
0.0163049,
-0.015610507,
-0.017012648,
0.004269854,
-0.011490882,
0.0011375706,
0.005451659,
0.0017309769,
-0.011604389,
-0.0045903437,
-0.0057721483,
-0.031034062,
-0.0036288754,
-0.002296841,
-0.0318887,
-0.008820137,
0.0064531886,
0.04847403,
-0.00915398,
0.04983611,
-0.018868817,
0.003819166,
0.037924584,
-0.008225895,
0.011230485,
0.0019696748,
0.008452909,
-0.0025922921,
-0.00447016,
0.017146185,
0.001013214,
0.012211983,
0.012185276,
0.012659333,
-0.0002789677,
0.0011492551,
-0.024423966,
0.009354286,
-0.025185129,
0.010148833,
-0.0150095895,
0.015904289,
0.017934056,
0.00008325214,
0.00559855,
0.0028276518,
0.004393376,
0.017813873,
-0.009254132,
-0.0055384585,
-0.01626484,
0.0072577507,
-0.00047572653,
0.010636244,
-0.0072644274,
0.0034486,
-0.009214072,
0.0034519385,
0.008339402,
0.005374875,
0.039099712,
-0.0048140185,
0.0020648201,
-0.006262898,
0.014435379,
0.034425907,
-0.0012619272,
0.018628448,
0.025572388,
0.017600212,
-0.01852162,
0.041129477,
0.021940174,
0.014168304,
0.015770752,
0.00055209314,
-0.016318254,
0.0006998188,
-0.011343991,
0.029191246,
0.008172481,
0.010836549,
0.019282782,
-0.017707042,
0.006543326,
-0.020618154,
0.006292944,
0.013600771,
-0.015463616,
0.0017159539,
0.011023502,
0.020524679,
0.027281664,
-0.012138538,
0.000106151696,
0.018441496,
-0.02680093,
-0.0048474027,
0.0068771695,
-0.005541797,
-0.010369169,
-0.0018277913,
-0.0036555827,
-0.016692158,
0.02443732,
0.018588388,
-0.045723163,
0.011170393,
-0.004463483,
0.027855875,
0.0059424085,
0.013674216,
0.0007369588,
-0.024998177,
-0.04890135,
-0.002265126,
0.012078446,
-0.016251486,
-0.009314224,
-0.04374681,
-0.011016825,
-0.025291959,
0.002033105,
-0.005227984,
0.0131934825,
0.0030129347,
0.0077918996,
-0.0017109463,
0.017466675,
0.022153834,
0.013300312,
0.03482652,
-0.010649597,
0.0055851964,
-0.013994706,
-0.009113919,
-0.02895088,
0.02927137,
0.014822637,
-0.01777381,
-0.010836549,
0.003139795,
-0.021325901,
0.0016750582,
-0.021179011,
-0.0018928908,
0.020511325,
0.009394347,
-0.009174011,
0.010723042,
0.003922657,
0.06452521,
-0.018575035,
-0.00823925,
-0.042651802,
-0.025705924,
-0.0028109595,
0.020377787,
0.027094712,
0.009895111,
-0.007624978,
-0.002969535,
-0.0013946298,
-0.011076917,
-0.023596035,
0.02113895,
-0.011931555,
0.0064164656,
-0.0063530356,
-0.0068571386,
-0.0026807606,
-0.005041032,
0.011904848,
-0.013587417,
0.0011784664,
-0.015343432,
-0.0058021946,
0.0012201968,
-0.0029161202,
0.01902906,
0.027642215,
0.02852356,
0.0027592138,
0.01626484,
0.0055952114,
-0.002188342,
-0.008566416,
-0.015490323,
-0.01153762,
0.00621616,
-0.00021678941,
0.007818607,
-0.01547697,
0.009921819,
0.01390123,
-0.0051211542,
0.015877582,
0.024557505,
0.011898171,
0.011584358,
-0.0023919863,
-0.0007265262,
-0.0068571386,
-0.007571563,
-0.0055851964,
0.0048674336,
-0.021005413,
0.018174423,
-0.035147008,
-0.014208365,
-0.004804003,
0.005465013,
0.009073857,
-0.013180128,
-0.01913589,
0.011364021,
-0.021913465,
-0.021846697,
-0.011063563,
0.006943938,
0.0041129477,
-0.025171775,
-0.029485028,
-0.0022067034,
0.00012373063,
-0.02296841,
-0.012933085,
0.0047906497,
-0.006903877,
-0.036268722,
0.009481146,
0.0050744163,
0.012719425,
0.016798988,
-0.018267898,
-0.0050477087,
0.024450675,
-0.0049008178,
-0.039366785,
-0.004069548,
-0.037737634,
-0.0020297666,
0.006102653,
-0.016612036,
-0.0077117775,
-0.013821107,
0.02522519,
0.025919585,
-0.011190423,
0.0068437853,
-0.015183188,
-0.005521766,
-0.0016558622,
0.016011119,
-0.00007182844,
0.0014580601,
-0.0005195434,
-0.021152303,
-0.04689829,
0.0054383054,
-0.013420495,
0.0019980513,
-0.015143126,
-0.015530384,
0.0024554166,
-0.029939055,
-0.022006942,
0.017039355,
-0.007985529,
0.0048373877,
-0.003246625,
0.03074028,
0.032155775,
-0.00813242,
0.007638332,
0.0051445235,
-0.028256487,
0.0034052003,
-0.014021413,
0.022741398,
-0.004723881,
-0.032209188,
0.008826814,
0.012265398,
-0.029137833,
-0.034025297,
0.0015248287,
-0.0135072945,
0.025852816,
-0.0018928908,
-0.01794741,
-0.018294606,
-0.021953527,
-0.0011384052,
0.0027558755,
0.0018494911,
-0.006116007,
0.0056853495,
0.020257603,
0.0017159539,
-0.012525796,
0.01198497,
-0.037310313,
-0.002273472,
0.021072181,
0.026413672,
0.0029177894,
0.0067436323,
0.02156627,
0.0058656246,
-0.0010566136,
0.016571974,
-0.036882993,
-0.002303518,
-0.022754751,
0.01913589,
0.052480146,
0.021779928,
0.017813873,
0.02350256,
0.022060357,
0.006787032,
-0.014649038,
0.011010148,
0.0042765313,
-0.01977687,
0.02722825,
0.0052079535,
0.003912642,
0.019269427,
-0.014675746,
0.01752009,
0.01594435,
-0.007524825,
-0.020177482,
0.0164785,
-0.04238473,
-0.024811225,
-0.016812343,
0.016238132,
-0.0032449556,
-0.03893947,
-0.0067069093,
0.011591035,
0.004370007,
-0.017586859,
0.0035787988,
0.032770045,
0.027642215,
0.029671982,
-0.012839609,
0.0232889,
-0.0013487265,
-0.017960763,
-0.012025031,
0.01390123,
0.004663789,
0.0024737779,
0.018494911,
0.01830796,
-0.0017142846,
-0.0033551238,
0.005498397,
-0.030499913,
-0.019149244,
-0.0150095895,
-0.03156821,
-0.014956174,
-0.032663215,
-0.008987058,
-0.019763516,
-0.011444144,
0.018481558,
-0.018294606,
0.009374317,
-0.023248838,
-0.011918201,
0.02561245,
-0.020070652,
0.01287967,
-0.007391288,
0.02988564,
0.039633863,
-0.011096947,
-0.014355256,
-0.015677275,
0.004710527,
0.0041429936,
0.051946,
0.0015331748,
0.009547914,
-0.020164128,
-0.012525796,
0.0009781605,
-0.023889817,
-0.03723019,
0.0066301255,
0.013053268,
-0.0027925982,
-0.009507854,
0.011510912,
-0.02450409,
0.015396847,
-0.002265126,
0.0129931765,
0.0057721483,
0.0019913747,
-0.036375552,
0.022834873,
0.006139376,
0.020724984,
0.020417849,
-0.011931555,
-0.030446498,
-0.009127272,
-0.013954645,
0.00672694,
0.010015295,
0.009421054,
-0.0078052534,
-0.0018862139,
0.027962705,
0.008292665,
0.007998883,
-0.004940879,
0.00012946855,
0.03493335,
-0.0029812194,
0.0039093033,
0.029431615,
-0.005658642,
0.00870663,
-0.016037825,
-0.0023402406,
-0.0017176231,
-0.03784446,
0.0023318946,
0.033651393,
0.015650569,
0.028710512,
0.004623728,
-0.018267898,
-0.012519119,
-0.004563636,
-0.00836611,
-0.00017443307,
-0.033411026,
0.002166642,
0.009541238,
0.016251486,
0.010162186,
0.01324022,
0.0133403735,
0.016545268,
0.035093594,
-0.0063029593,
0.0343992,
0.012539149,
-0.0022634568,
-0.012425643,
0.0019296135,
-0.023168717,
-0.031861994,
-0.014408671,
-0.0150095895,
-0.028603682,
-0.0038291812,
0.0032850169,
0.013140067,
-0.014929467,
0.010188893,
0.0008863536,
0.007831961,
0.019816931,
-0.011911524,
-0.016825696,
0.007478087,
-0.03859227,
-0.013073299,
-0.0019963821,
-0.019082475,
0.0003332172,
0.0009130611,
-0.020043945,
0.0011934893,
-0.023983294,
-0.016798988,
-0.015236602,
0.016812343,
-0.017613566,
-0.00009624073,
-0.02218054,
0.009895111,
-0.012812901,
-0.0043733455,
0.006690217,
-0.017934056,
-0.01494282,
0.020217543,
0.00056544686,
0.028229779,
-0.03461286,
0.014048121,
0.0011751279,
-0.018241191,
-0.014595623,
0.003859227,
-0.00994185,
0.04396047,
0.015637213,
-0.007845314,
-0.032957,
0.011744603,
-0.0465778,
-0.029618567,
0.0027875905,
0.0039860876,
-0.011524267,
0.011016825,
-0.020805107,
-0.021993589,
-0.011624419,
-0.016278192,
-0.0038225043,
-0.012058415,
0.054590035,
-0.0052847373,
0.003765751,
0.016745573,
-0.040969234,
-0.017640274,
0.025171775,
0.009340932,
-0.0009439416,
0.027962705,
0.017600212,
0.043559857,
0.0110301785,
0.026747515,
-0.0012444004,
-0.007331196,
0.017426614,
-0.043479737,
-0.019683393,
-0.00096480676,
-0.021112243,
-0.0004844899,
0.016184717,
-0.008973705,
-0.007090829,
-0.0055184276,
0.015490323,
-0.03755068,
-0.011130331,
-0.01004868,
0.016852403,
-0.0044434527,
-0.0051512,
0.024330491,
0.007978852,
-0.01198497,
-0.0017259693,
0.021192364,
0.02243426,
-0.030793695,
0.0031982176,
-0.0027325065,
-0.009841696,
-0.0069105537,
0.0027675598,
-0.03244956,
-0.014956174,
-0.001140909,
-0.0058589475,
-0.008232573,
0.011744603,
-0.010783135,
-0.0179207,
-0.003465292,
-0.006773678,
-0.015583799,
-0.00040561944,
-0.0012769501,
0.005334814,
-0.0071108597,
0.017212953,
-0.013373758,
-0.013847815,
-0.0065600183,
-0.005575181,
-0.0076984237,
0.00502434,
0.031381257,
0.20105371,
-0.010135478,
0.005852271,
0.029111125,
0.007144244,
-0.019055769,
0.0050376933,
0.005798856,
0.0032583093,
-0.004647097,
0.02429043,
-0.008846845,
0.01311336,
-0.0072043356,
0.020230897,
-0.011163716,
-0.016598683,
-0.012158568,
-0.016665451,
-0.023008471,
0.006997353,
-0.021406025,
0.017172894,
0.005211292,
-0.006983999,
-0.007978852,
-0.018080946,
0.00027604657,
-0.0009673106,
0.020084005,
-0.044734985,
0.0047806343,
0.007885376,
-0.0059424085,
0.012298782,
-0.003425231,
-0.0046904967,
0.00040666273,
0.015129773,
-0.00336347,
-0.008466263,
0.003471969,
-0.0029294738,
0.0134872645,
-0.017653627,
0.00033530375,
0.0015164827,
0.005892332,
0.011150362,
-0.0050376933,
-0.04564304,
0.009808312,
0.030152716,
0.01673222,
0.0072176894,
-0.011550974,
-0.009247456,
0.037283607,
0.011430791,
0.03244956,
-0.00811239,
-0.0017576843,
-0.006997353,
0.03877922,
-0.024837932,
0.013567386,
-0.0072978116,
-0.016438438,
0.030820401,
-0.02181999,
-0.00232021,
-0.01924272,
-0.028149657,
-0.016772281,
-0.009267487,
-0.015236602,
0.04174375,
0.010342462,
0.014649038,
0.016037825,
0.0073979646,
0.0009781605,
-0.037390437,
0.0071175364,
0.006943938,
-0.029565152,
0.022087064,
0.011170393,
-0.010950056,
-0.013380434,
0.0073979646,
-0.010809842,
-0.0022951718,
-0.008853521,
0.004563636,
-0.00092724944,
0.012966469,
-0.0140748285,
-0.020898582,
-0.02145944,
-0.018481558,
0.07018719,
-0.001630824,
-0.0028560283,
0.016465146,
0.0018461527,
-0.0031932099,
-0.011183746,
-0.021539561,
-0.020003883,
0.016718866,
-0.043346196,
-0.0074981176,
-0.027935997,
-0.0069639687,
0.021993589,
0.009554592,
-0.0300993,
0.03682958,
-0.0007987198,
0.016545268,
0.0006021696,
-0.013367081,
0.018441496,
0.005171231,
-0.0032833477,
0.010035326,
0.0053247986,
-0.00521463,
-0.01605118,
-0.014328549,
-0.009634714,
0.01756015,
0.0033768236,
-0.0030913877,
0.00017683256,
0.016518561,
-0.0020881891,
-0.002837667,
-0.011223808,
-0.016518561,
-0.00026060632,
0.012532473,
-0.0010282369,
0.0060559153,
0.0045436057,
0.038191658,
0.041957412,
0.008172481,
-0.030393083,
0.0057821637,
-0.0049675866,
0.009447762,
-0.021058828,
0.028710512,
-0.016705513,
-0.0098750815,
-0.00242704,
-0.013427173,
0.010422584,
-0.026507149,
0.02282152,
-0.007324519,
-0.0002612323,
-0.024570858,
-0.0147158075,
-0.1683638,
0.008780075,
0.037897877,
-0.019977175,
0.010255663,
0.009427731,
0.0088668745,
-0.00003077617,
-0.020404495,
0.00009029415,
0.037310313,
-0.0017610227,
-0.0142217195,
-0.027855875,
-0.00024307956,
-0.0012043392,
-0.018548327,
0.03178187,
0.014395318,
-0.0032850169,
0.036375552,
-0.015116419,
0.010255663,
-0.019549856,
0.027214896,
-0.022167187,
0.0031214338,
0.007184305,
-0.029565152,
-0.025145069,
-0.005668657,
0.006950615,
0.017186247,
-0.022127125,
0.0003455277,
0.02203365,
-0.0029495044,
0.010255663,
-0.006937261,
0.030473204,
0.023569329,
0.005311445,
-0.0010015295,
0.0064364965,
-0.008993736,
0.009768251,
-0.018681863,
0.004546944,
0.025425496,
-0.011444144,
0.011137009,
-0.002737514,
0.012746132,
0.027615508,
0.024717748,
0.017600212,
0.017212953,
0.012619272,
-0.007845314,
0.002590623,
-0.00974822,
-0.009441085,
0.03389176,
-0.008987058,
-0.011911524,
-0.024090124,
0.013994706,
0.004817357,
-0.044548035,
0.025625803,
-0.0034953381,
-0.0051378463,
-0.0052313227,
-0.030606743,
0.0412096,
0.0019780209,
-0.003216579,
-0.014168304,
-0.014902759,
-0.008085682,
-0.02271469,
0.02790929,
-0.021726513,
-0.0044868523,
-0.01006871,
0.025105007,
0.015757399,
0.014608977,
-0.015103065,
0.003525384,
0.013740985,
-0.023475852,
0.009594653,
-0.011597712,
0.029832225,
0.0030713573,
-0.018027531,
-0.03568116,
-0.007765192,
-0.0068704924,
0.018027531,
-0.0048607565,
-0.0018678525,
0.030126007,
0.026200013,
0.0134872645,
-0.009467793,
0.004169701,
0.034853227,
-0.019336198,
-0.01458227,
-0.009414378,
0.0148626985,
0.041797165,
0.0012018355,
0.014515501,
-0.004223116,
-0.0124056125,
0.021299195,
-0.02113895,
0.058702983,
0.009794959,
0.0035787988,
0.03795129,
0.010248985,
-0.0075181485,
-0.1325758,
-0.013847815,
-0.00006426481,
0.025679218,
0.0010290716,
0.030820401,
-0.012812901,
0.023168717,
-0.016465146,
0.02049797,
0.00029127818,
-0.018254545,
0.010322431,
-0.0007265262,
0.029752104,
0.0052713836,
-0.00811239,
-0.014128244,
-0.012025031,
0.036268722,
-0.00146891,
0.005838917,
-0.01526331,
-0.018601742,
0.015089711,
0.009668099,
-0.037363727,
0.03712336,
0.0300993,
0.022020295,
0.021472793,
-0.025105007,
0.034559444,
0.008713307,
-0.0047305576,
-0.007177628,
-0.013013207,
-0.03421225,
0.0164785,
-0.012933085,
0.0021716498,
0.014448732,
-0.0041930703,
0.0018728602,
0.010369169,
-0.009007089,
-0.008826814,
-0.00823925,
-0.004216439,
-0.022193894,
-0.020671569,
-0.022100419,
-0.016865756,
0.0004102098,
0.011464175,
-0.015543738,
0.019870346,
0.01268604,
-0.0171996,
-0.00983502,
-0.00082250615,
0.0024938085,
0.001762692,
-0.003572122,
0.020698277,
-0.009981911,
-0.031541504,
-0.038859345,
0.028390024,
-0.03538738,
0.00014616072,
0.017934056,
-0.026760869,
0.006179437,
-0.009147303,
-0.0012277083,
-0.0077117775,
-0.010616213,
-0.0033718161,
-0.015570446,
-0.009367639,
-0.020270957,
0.029431615,
0.0005675334,
0.016251486,
0.012398936,
0.029324785,
-0.018348021,
0.018374728,
0.0017376537,
0.002899428,
0.028176364,
0.00034782285,
-0.020631509,
-0.0041429936,
-0.0016233125,
-0.030499913,
0.0001332243,
0.012225337,
0.018334666,
-0.033411026,
-0.016892465,
-0.056406144,
0.021392671,
0.00713089,
-0.00053414906,
0.0198837,
-0.020751692,
-0.0019730132,
-0.005458336,
0.014021413,
-0.013427173,
-0.029565152,
0.0037857816,
-0.016037825,
-0.004957571,
-0.020684924,
0.0047439113,
0.025145069,
0.002412017,
0.019656686,
0.026079828,
-0.009113919,
-0.030553328,
-0.0036489058,
0.011671158,
-0.0098016355,
0.017493382,
-0.013654185,
0.019616624,
-0.0051912614,
-0.0049776016,
-0.0010023641,
-0.030179422,
-0.02690776,
0.000101613514,
-0.011757957,
-0.006983999,
0.01042926,
0.017573504,
0.015930997,
0.018708572,
-0.0015999434,
-0.03915313,
-0.014141597,
0.017600212,
-0.0011308937,
0.010569475,
-0.030766986,
0.005147862,
0.00036451503,
-0.014235073,
0.029618567,
0.0037757664,
-0.002707468,
-0.04163692,
-0.021472793,
-0.004807342,
-0.006363051,
0.008099035,
0.028496854,
-0.01594435,
0.017186247,
0.0066067562,
0.021633038,
-0.0056619802,
-0.023956586,
-0.006503265,
-0.025812754,
0.025719278,
-0.0059090243,
-0.022487676,
-0.008172481,
0.00974822,
0.011831402,
-0.0028259824,
0.007384611,
0.0071175364,
0.008760045,
0.01645179,
0.001515648,
0.0040929173,
0.022888288,
0.014275135,
-0.028229779,
0.022260662,
0.02722825,
-0.0077451617,
-0.0022718029,
0.03397188,
-0.0062729134,
0.00065600185,
-0.014969528,
0.011604389,
0.019069122,
-0.0006238694,
0.022367492,
0.033117242,
-0.00327834,
0.01999053,
0.00894032,
0.015022943,
-0.0073512266,
0.008105712,
0.015784105,
-0.020017236,
-0.0078119305,
-0.0021799959,
-0.038565565,
-0.03490664,
-0.0063062976,
-0.008606477,
-0.007030737,
0.008860198,
-0.004657112,
-0.00338517,
0.00032967015,
0.018855462,
0.018080946,
-0.021913465,
-0.009794959,
0.039393496,
0.01098344,
0.019483088,
0.00627959,
0.009928496,
0.012098476,
0.023983294,
0.016425084,
-0.025679218,
0.02103212,
0.026066475,
0.0075515327,
0.0059490856,
-0.03279675,
-0.009521208,
-0.0071575977,
-0.008853521,
0.0026840991,
0.021285841,
-0.0073178424,
0.08476946,
0.0038158274,
-0.00036159388,
-0.0017610227,
-0.015744044,
0.034666274,
0.02181999,
0.00915398,
-0.030499913,
-0.021993589,
0.022888288,
-0.026640685,
0.026039768,
-0.03196882,
-0.008586447,
0.03218248,
-0.023008471,
0.017333137,
-0.010088741,
-0.020230897,
0.0034786458,
-0.0031347873,
0.015917642,
0.009574622,
-0.016171364,
-0.011237161,
0.017707042,
-0.005404921,
0.011290576,
-0.017747102,
-0.002313533,
0.010415907,
-0.04508218,
-0.018802047,
-0.016024472,
0.028229779,
0.00005070243,
-0.019977175,
0.0009372647,
0.0073645804,
-0.010062033,
0.012973146,
-0.012232014,
-0.015623861,
-0.01049603,
0.00023682001,
0.0002933647,
0.004957571,
-0.0035520913
] |
Boundary elements hinder the spread of heterochromatin, yet these sites do not fully account for the preservation of adjacent euchromatin. Histone variant H2A.Z (Htz1 in yeast) replaces conventional H2A in many nucleosomes. Microarray analysis revealed that HTZ1-activated genes cluster near telomeres. The reduced expression of most of these genes in htz1Delta cells was reversed by the deletion of SIR2 (sir2Delta) suggesting that H2A.Z antagonizes telomeric silencing. Other Htz1-activated genes flank the silent HMR mating-type locus. Their | [
-0.03329925,
-0.008915517,
-0.013283982,
-0.017405177,
-0.020331224,
0.04132184,
-0.016031444,
0.0017875679,
-0.019671833,
-0.008139358,
-0.005762803,
0.0015334276,
0.00960925,
0.009780967,
-0.0042516985,
-0.011566818,
0.020427385,
0.0008190873,
0.00987026,
-0.0067415866,
-0.045168288,
-0.0022323134,
-0.0063638105,
-0.026375642,
-0.021045564,
0.040470127,
0.021677481,
-0.0347554,
-0.016965581,
-0.0007718653,
0.006724415,
0.00894986,
-0.016278716,
-0.0023902925,
-0.02413646,
0.0013531253,
0.015880335,
-0.016718311,
0.026513014,
-0.019905368,
0.012013281,
0.014300543,
-0.01033046,
-0.013812869,
0.000012194549,
-0.0008564356,
0.016223768,
-0.0080088535,
0.0025053425,
0.02520797,
0.0072601703,
0.021279098,
-0.017048005,
0.005711288,
-0.030084716,
-0.020674657,
0.0094169285,
0.006999161,
-0.01416317,
0.0025705947,
0.00058297726,
-0.010605206,
-0.03514005,
0.007940168,
-0.010158743,
0.007960773,
-0.005385027,
-0.009595513,
-0.0011453485,
-0.008929254,
0.033326723,
0.013895293,
-0.01594902,
0.00023975904,
0.01395711,
-0.045635354,
-0.012239946,
-0.0076173404,
0.005824621,
-0.011175305,
0.034068536,
-0.00046277573,
-0.011518737,
-0.009224606,
0.029919868,
0.0112989405,
0.004615737,
0.009004809,
0.0073013823,
-0.00549836,
0.02019385,
0.030414412,
0.022968788,
0.029727546,
-0.026650388,
0.011264597,
0.0070541105,
0.0048149284,
0.009842785,
-0.01835305,
-0.011086012,
0.0021584753,
-0.009272686,
-0.013881555,
-0.01820194,
-0.011051669,
0.021952227,
-0.0050690686,
-0.0076516834,
-0.01257651,
-0.02787301,
0.01861406,
-0.012816913,
-0.024768377,
0.038409527,
-0.012418531,
0.011580555,
-0.0037056403,
-0.00072678976,
0.0025242313,
0.010694498,
0.035414793,
0.0030393805,
-0.01769366,
0.024658477,
0.014589027,
-0.009925209,
-0.013132871,
-0.006789667,
-0.019548196,
0.036953375,
0.020935666,
-0.0013050447,
0.010440358,
-0.02781806,
0.003001603,
-0.020619707,
-0.03409601,
-0.01125086,
-0.043904454,
0.011972069,
0.031403497,
-0.008936122,
-0.02152637,
0.023119899,
0.018572848,
-0.0051480583,
0.022336872,
-0.008262994,
0.015825385,
-0.0028144321,
-0.027241092,
0.0036987716,
-0.016663361,
0.0027268566,
0.022625355,
-0.0155231645,
0.00217393,
-0.023600705,
-0.012466612,
-0.011834696,
0.018325577,
0.020921929,
0.022364346,
0.010158743,
0.029178053,
-0.003211097,
-0.01641609,
-0.005041594,
-0.016786996,
-0.014032666,
0.004598566,
-0.033766318,
-0.005793712,
-0.008771274,
0.00097105635,
-0.009519958,
0.019671833,
-0.028065331,
-0.023834238,
-0.01927345,
0.0007632795,
0.0146302385,
0.007837137,
-0.022281922,
0.01912234,
0.023793027,
-0.0007667138,
-0.0025534232,
-0.0033141267,
-0.0027800887,
-0.0016064071,
-0.0075692595,
-0.012686409,
-0.6325758,
-0.011360758,
-0.0016725179,
-0.015797911,
-0.0017686791,
0.013366406,
0.011086012,
0.0015394377,
-0.021636268,
0.0155231645,
-0.021718692,
0.0147264,
0.009361979,
-0.013002367,
-0.030689158,
-0.029040681,
-0.0072120894,
-0.007102191,
0.04689919,
0.020290012,
-0.028601086,
-0.006034115,
-0.016938107,
0.010323591,
0.020207588,
0.006903,
0.028298866,
-0.014382967,
-0.004643212,
0.01079066,
-0.021746168,
0.009217737,
-0.022707779,
0.008702588,
0.054674506,
0.013826606,
-0.0014054988,
0.029974818,
0.0348653,
0.024246357,
0.0074868356,
-0.00054477033,
0.034535605,
0.013277113,
-0.014589027,
0.016168818,
-0.008963597,
0.02193849,
0.012968024,
-0.0104060145,
0.004770282,
-0.009753493,
-0.012583379,
0.0117591405,
0.008709457,
0.018421737,
0.024892012,
-0.01079066,
0.01835305,
0.014643976,
-0.0012200451,
0.03176067,
0.0064908806,
-0.012610854,
-0.009897734,
-0.0043581626,
0.0049660387,
0.0072945133,
0.009739755,
0.016855683,
-0.021279098,
0.028436238,
-0.0010234298,
0.023325957,
0.0077615823,
0.02055102,
-0.008187438,
-0.004557354,
-0.025345344,
0.03165077,
0.015756698,
-0.0036129134,
-0.028710986,
-0.01416317,
0.025400292,
-0.018490424,
-0.029178053,
0.029178053,
-0.0066900714,
0.004598566,
-0.0015892354,
0.020358698,
-0.009052889,
-0.013716707,
-0.021498896,
0.022419296,
0.018325577,
-0.00025907715,
0.0003309834,
-0.009004809,
-0.013256507,
-0.017020531,
-0.0013780242,
-0.00056623487,
0.008290469,
-0.0033192784,
-0.016690835,
-0.0053609866,
0.035277423,
-0.0051961388,
-0.0068377475,
0.00023138786,
-0.025372818,
-0.012796307,
0.002529383,
-0.01728154,
0.044151723,
0.029947342,
-0.011972069,
-0.023710603,
0.028518662,
0.010859346,
-0.005154927,
-0.029672597,
0.022268185,
0.029068155,
0.011539343,
0.003377662,
-0.022611618,
-0.02526292,
0.0037880642,
0.0030805925,
0.019905368,
-0.031623296,
0.014300543,
0.006274518,
0.0058108834,
0.0013934787,
0.027268566,
-0.015427003,
-0.019053653,
0.0046466463,
0.0045058387,
0.0021275664,
-0.0014072161,
-0.0386568,
-0.006034115,
0.004203618,
0.013105397,
-0.006003206,
0.013201558,
0.0101244,
-0.023257272,
-0.0074937046,
-0.005690682,
-0.017061744,
-0.010213693,
-0.032859653,
-0.011738534,
-0.01641609,
0.011106618,
0.013524385,
0.012624591,
-0.011374496,
-0.014259331,
-0.020812029,
0.018146992,
-0.012562773,
-0.018792644,
-0.013338931,
0.01191025,
-0.011415708,
-0.03247501,
-0.0034343284,
0.009272686,
0.014080746,
-0.011360758,
0.01677326,
-0.024946962,
-0.0117591405,
-0.0017772649,
-0.009629857,
-0.009231474,
-0.022254448,
0.03901397,
0.015536902,
0.026375642,
-0.008111884,
0.009272686,
0.03134855,
0.0052751284,
0.007383806,
-0.00869572,
0.018146992,
-0.0009959552,
-0.015385791,
0.027584525,
0.004382203,
0.0009993896,
0.013064185,
0.018119516,
-0.00585553,
0.0041280626,
-0.028628562,
0.007397543,
-0.034041062,
0.00094701606,
-0.0075555225,
-0.0030479664,
-0.0061337105,
0.003966649,
-0.005618561,
-0.008208045,
0.01052965,
-0.011463788,
0.0077409763,
-0.0070541105,
0.002980997,
0.0052888654,
0.0065492643,
-0.007459361,
-0.0027543313,
0.011875907,
0.0037056403,
0.0013041862,
0.0017085783,
0.016402353,
0.012363582,
-0.0035236208,
0.004028467,
0.001985042,
0.0094444025,
-0.021553844,
0.016072657,
0.0062710834,
0.014005191,
0.0229001,
0.002603221,
0.022474244,
0.009629857,
-0.005134321,
-0.002029688,
-0.006875525,
-0.01692437,
0.012446006,
-0.009732886,
0.03181562,
0.0075486535,
-0.012610854,
0.011621767,
0.01094177,
-0.0012629742,
0.0033450357,
-0.007905824,
0.020441122,
-0.017638711,
0.010062582,
0.004059376,
0.028010381,
0.014520341,
0.012810045,
-0.017638711,
-0.01125086,
-0.033271775,
-0.008352286,
-0.0053815925,
0.013613678,
0.00012427976,
-0.006882394,
0.0033141267,
-0.008297337,
0.020633444,
0.011491262,
-0.028463714,
0.0057181567,
0.0043169507,
0.008860568,
0.026004734,
0.02224071,
0.0030874612,
-0.008867436,
-0.044673745,
0.03373884,
0.017144168,
-0.02648554,
-0.029727546,
-0.022913838,
0.0117591405,
-0.0009075213,
0.015468215,
0.011031062,
-0.0017600933,
0.0014252462,
0.0034205911,
-0.011134093,
-0.0019421127,
0.01769366,
-0.019259714,
0.01784477,
0.012480349,
0.004196749,
0.00082595594,
-0.02787301,
-0.012219341,
0.038409527,
0.017570024,
0.0029208963,
0.0041074567,
-0.0128856,
-0.026815236,
0.0054021985,
-0.010096925,
0.010962376,
0.0047290702,
-0.003116653,
-0.010412884,
-0.0010800962,
0.0066110822,
0.015481953,
-0.015742961,
-0.035359845,
-0.010117532,
-0.022474244,
0.014698925,
0.021155462,
0.049316954,
-0.019300925,
-0.0011762575,
-0.015427003,
0.013593071,
-0.012597117,
-0.026513014,
-0.0074318866,
-0.02479585,
-0.03206289,
-0.009039152,
-0.005354118,
-0.006518355,
0.017157905,
0.015481953,
0.009231474,
-0.04014043,
-0.022309396,
0.0027423112,
0.009382585,
-0.0037605895,
0.0074662296,
0.048135545,
0.039343666,
-0.008606426,
-0.0035648327,
0.024809588,
0.023298483,
-0.023916662,
-0.010618943,
0.012239946,
0.0060409834,
0.005199573,
0.0044852328,
-0.026279481,
0.002385141,
-0.00333645,
0.0031183702,
-0.017885981,
-0.009712281,
0.033216823,
0.017872244,
-0.0020537283,
-0.0201389,
-0.0043547284,
0.0103922775,
0.022474244,
-0.02633443,
-0.007122797,
0.011855301,
-0.024383731,
-0.012404794,
-0.027598262,
0.0033982678,
-0.028010381,
-0.02055102,
-0.015536902,
-0.008290469,
-0.011669848,
-0.0038704881,
-0.013263376,
0.020441122,
-0.01033046,
0.00217393,
-0.011106618,
0.013764788,
-0.026252005,
-0.018462949,
-0.011037931,
-0.0018201941,
-0.027680686,
-0.04310769,
-0.0030874612,
0.03544227,
0.014259331,
-0.005223613,
0.0005924216,
-0.006916737,
0.01876517,
-0.009114708,
-0.025688777,
0.0024332216,
-0.023243533,
0.018133253,
-0.018215677,
0.014135695,
-0.0057765404,
-0.004684424,
-0.0016364575,
0.0038704881,
-0.03544227,
0.021388996,
-0.012590248,
-0.008420973,
0.019658096,
0.008070672,
0.017666185,
0.0038395792,
-0.0059997714,
-0.0202488,
-0.036843475,
-0.010818134,
-0.033409145,
-0.005553309,
-0.015729224,
0.009135313,
0.0019300926,
-0.009705412,
-0.0059860344,
-0.013737313,
-0.0069819894,
-0.010440358,
0.010364803,
0.015990233,
0.024328781,
0.008111884,
0.029590173,
-0.037090745,
0.0056769447,
0.016580937,
-0.014959934,
0.0018528202,
-0.0023507976,
-0.016388616,
0.023793027,
0.008750669,
-0.014094483,
-0.0058314893,
-0.00853774,
-0.0059001762,
0.03926124,
-0.008613296,
-0.011889645,
-0.02781806,
-0.008166833,
0.0025482716,
-0.0029672596,
0.021210412,
0.0009075213,
-0.0103785405,
0.0071090595,
-0.0029260477,
-0.030084716,
-0.024548579,
-0.039041445,
-0.007438755,
0.04090972,
0.0080225915,
0.004749676,
0.0030342292,
0.0027131194,
0.0031664507,
-0.02280394,
-0.008173701,
-0.030744107,
0.015427003,
0.001401206,
0.02699382,
0.018270627,
0.036184084,
0.005889873,
0.0127894385,
0.02250172,
0.011717929,
0.0068446165,
-0.019081129,
0.04321759,
-0.0026684732,
0.026622914,
0.018916281,
0.008867436,
0.017501337,
-0.0003344177,
0.03373884,
0.010618943,
-0.0033879648,
-0.0257712,
0.023710603,
-0.05077311,
-0.016704572,
0.0072120894,
-0.019383349,
-0.013792262,
-0.027488364,
-0.0042070523,
0.0032883694,
-0.0043719,
0.026155844,
-0.0033003895,
0.027776849,
-0.010220561,
0.036074184,
-0.021787379,
0.016388616,
-0.015001146,
-0.0032025112,
0.0029827142,
-0.004979776,
0.048767462,
0.0029088762,
0.0044783643,
0.006305427,
-0.021004353,
0.012954286,
0.008269862,
-0.030496836,
-0.009313898,
-0.0055052284,
-0.0072326954,
0.000053768705,
-0.019905368,
-0.005240785,
-0.044289097,
0.0009015112,
-0.012707015,
0.002845341,
0.02060597,
0.0028367552,
-0.0076997643,
0.030002292,
0.002301,
0.040772345,
0.008139358,
0.029672597,
0.0067587583,
-0.0031990767,
-0.019974053,
-0.017130429,
-0.007864612,
0.025125546,
0.024012825,
0.008647638,
-0.0057284595,
0.0050793714,
0.018394263,
0.009368848,
-0.006652294,
-0.04310769,
-0.0063535073,
-0.007267039,
0.010509045,
-0.016319929,
-0.0076585524,
-0.0146577135,
-0.00493513,
-0.0067003747,
0.028216442,
0.006181791,
-0.002383424,
-0.01079066,
0.020276275,
0.0064393654,
0.015481953,
-0.005323209,
0.016182555,
-0.011202779,
-0.016786996,
0.018462949,
-0.002259788,
-0.0046912925,
0.04382203,
-0.035524692,
0.00020799151,
0.012294895,
0.014740137,
-0.019822944,
-0.01861406,
-0.016264979,
0.039563462,
-0.022652829,
-0.0074112806,
0.003461803,
0.0089567285,
0.008194308,
0.03349157,
0.0074524926,
-0.007830269,
-0.013812869,
0.0038327104,
0.0155643765,
0.012521561,
0.0064496687,
-0.026155844,
-0.013338931,
-0.0055910866,
-0.03338167,
-0.02505686,
0.0136411525,
-0.04873999,
-0.006054721,
0.011498131,
-0.004516142,
0.014698925,
-0.001830497,
0.0005366138,
-0.025592614,
0.03593681,
-0.023683129,
0.013380143,
-0.0065080523,
0.001964436,
-0.031623296,
0.0094169285,
0.0007091888,
-0.02111425,
0.008194308,
-0.027213618,
-0.006769061,
0.002184233,
-0.0029311993,
0.023408381,
0.039316192,
-0.0036060447,
-0.005154927,
-0.0074318866,
0.03134855,
0.00027238516,
-0.0192185,
0.012727621,
-0.03181562,
0.0018270627,
0.0074112806,
-0.016580937,
-0.012088836,
-0.0059654284,
-0.011690454,
0.014259331,
0.0002565014,
-0.0065492643,
-0.0077753193,
0.013009236,
-0.0063741133,
-0.01487751,
0.008785012,
-0.020743344,
-0.015097307,
0.0061474475,
0.00045934142,
0.0011333283,
-0.012954286,
0.01098985,
-0.010344197,
0.020111427,
-0.012810045,
-0.0050896746,
0.004790888,
-0.027584525,
-0.048327867,
0.0031956425,
-0.0017197399,
0.0257712,
0.0094718775,
-0.022007177,
0.007603603,
-0.016745785,
-0.040937193,
-0.015179731,
0.0049866447,
-0.011683585,
0.0057490654,
0.0331344,
0.002414333,
-0.006016943,
-0.006538961,
0.013943373,
-0.0046054344,
-0.017679922,
-0.00960925,
-0.0027148365,
0.023229796,
0.015962759,
-0.036211558,
-0.0001528276,
0.0404976,
-0.006284821,
-0.026719075,
0.031430975,
0.00585553,
0.02746089,
0.017734872,
0.013283982,
0.012191866,
0.010605206,
0.021540107,
-0.030908955,
-0.0037708925,
0.0030977642,
-0.005573915,
-0.021814853,
0.014046403,
-0.00853774,
-0.00070661306,
0.00090322836,
0.0026701903,
-0.043849505,
0.015427003,
-0.025098072,
0.016017707,
0.028051594,
0.00961612,
0.019342138,
0.020496072,
-0.0033913993,
0.00045848283,
-0.009519958,
-0.01974052,
-0.007919561,
0.011546212,
-0.011010457,
-0.0024606963,
-0.009142182,
-0.0010028239,
-0.015413266,
0.022941314,
0.009004809,
-0.028518662,
-0.037200645,
0.0065973448,
0.0010534802,
0.004200184,
-0.0034223082,
-0.0034085708,
-0.02147142,
-0.0064050225,
0.014314281,
-0.018490424,
0.0030153403,
0.004392506,
-0.000028118564,
-0.027735636,
-0.013936505,
-0.0006804263,
-0.0146714505,
-0.014643976,
0.011079143,
0.18627797,
-0.0030994813,
-0.009732886,
0.009952684,
-0.0055670463,
-0.025070596,
0.018586585,
-0.008757537,
-0.00022194347,
0.004828666,
-0.0074250177,
0.0007568401,
-0.00822865,
-0.0044783643,
0.034068536,
-0.03211784,
-0.012542167,
-0.0015033772,
-0.037090745,
0.02372434,
0.0053094714,
-0.017501337,
0.00084613264,
-0.0057593687,
0.038849123,
-0.011937725,
-0.029233003,
-0.0022958484,
0.0070025953,
0.0072739073,
-0.04470122,
0.000025663556,
0.0132221645,
-0.016841946,
-0.019520722,
0.0061371448,
-0.014149433,
0.022927577,
0.0071914834,
0.011635505,
-0.0018854463,
0.0011384798,
-0.0049316953,
0.0073357252,
0.0014063575,
-0.0025602917,
0.0128856,
0.00052931585,
-0.0062367404,
-0.0069064344,
-0.024301307,
0.017267803,
0.00241605,
0.035524692,
-0.0003762736,
-0.005227048,
0.033244297,
-0.0020520112,
-0.017267803,
0.011992674,
-0.015111045,
0.0023714036,
-0.03338167,
-0.004828666,
-0.009966421,
0.038272154,
-0.015042358,
0.005124018,
0.020537283,
0.0007327998,
0.039398614,
-0.0024692821,
-0.026719075,
-0.005793712,
-0.005450279,
-0.0128856,
0.03236511,
0.021485157,
0.03231016,
0.020894453,
0.001964436,
-0.0039048314,
-0.0018974664,
0.011477525,
0.021196675,
-0.026045946,
0.045333136,
-0.00038271295,
-0.015220943,
-0.007940168,
-0.008778144,
-0.02603221,
-0.0033999851,
-0.016347403,
0.006748455,
-0.018009618,
-0.004468061,
0.019081129,
-0.009698544,
-0.019836681,
-0.018778907,
0.05011372,
-0.0004413112,
0.00028118564,
0.016965581,
-0.0021361522,
0.007878349,
0.0027800887,
0.0028006947,
0.008166833,
0.010309854,
-0.027035033,
0.00864077,
-0.0028092805,
-0.0004932554,
0.019314663,
0.008311074,
-0.038931545,
0.06022438,
-0.017240329,
0.012198734,
-0.014904985,
0.012349845,
0.03645883,
-0.011202779,
-0.004073113,
-0.023504544,
0.017707396,
-0.021965964,
-0.047833323,
0.010667024,
0.008750669,
0.023518281,
0.008881173,
0.0034961463,
-0.019726781,
0.0047015953,
-0.006913303,
-0.021334048,
0.013304588,
-0.0068171415,
0.00007437467,
0.025743725,
0.014080746,
-0.0132359015,
-0.040607497,
0.020221325,
0.0020777686,
-0.019204764,
-0.03272228,
-0.0057902774,
-0.016182555,
-0.017885981,
0.008132489,
0.0042310925,
-0.026142107,
-0.017734872,
-0.04939938,
-0.004368466,
0.033793792,
-0.017570024,
0.022968788,
0.019795468,
-0.016677098,
0.0016295888,
0.0021481724,
-0.17506832,
0.019548196,
0.019699307,
-0.044563845,
0.024603529,
0.036129136,
-0.0040456387,
-0.0028625126,
-0.009162788,
0.017089218,
0.011841564,
-0.01114783,
-0.016553463,
-0.035771962,
0.0057490654,
0.0031870566,
-0.006095933,
0.03181562,
0.039810736,
-0.0033175612,
0.016127605,
-0.01283065,
0.029672597,
0.0009839351,
0.02970007,
0.029370377,
0.0001058739,
0.003315844,
0.0052579567,
-0.015193469,
0.0008680265,
0.014149433,
0.017006794,
-0.007438755,
0.012583379,
-0.0013651456,
-0.0034051365,
0.00013404613,
-0.012864994,
0.010296117,
0.03211784,
-0.004770282,
0.0018923149,
-0.012336107,
-0.009368848,
0.032529958,
-0.0058314893,
-0.009197132,
0.023834238,
-0.010591469,
-0.009389454,
0.0015797911,
0.020812029,
0.040332753,
0.027447153,
0.00031059206,
-0.0005228765,
0.009835917,
-0.00823552,
-0.011662979,
-0.004557354,
-0.018902544,
0.035002675,
0.0045676567,
-0.0164573,
-0.030661684,
0.0010861063,
0.00848966,
-0.023037475,
0.0069819894,
-0.012301764,
-0.006923606,
0.013847212,
-0.02327101,
0.016759522,
0.019465772,
-0.009897734,
-0.0014338321,
-0.009135313,
0.009190262,
-0.02746089,
0.010083188,
-0.03461803,
-0.02096314,
-0.0003668292,
0.023490805,
-0.0103922775,
0.014506603,
0.008043197,
0.004052507,
0.018037092,
0.00088348094,
0.012191866,
-0.034590553,
0.032282688,
0.0071296655,
0.0011393385,
-0.0027577656,
-0.033711366,
-0.009856522,
0.011388233,
-0.03478288,
-0.013318325,
-0.0047325045,
0.045635354,
0.023504544,
-0.021196675,
0.016800735,
0.05676258,
0.0059070447,
-0.004845837,
-0.016732048,
0.008146226,
0.020990616,
0.0027165536,
0.045827676,
0.0075280475,
-0.016608411,
0.012130048,
-0.018284364,
0.056322984,
-0.0051927045,
-0.00051085633,
-0.013593071,
-0.012535298,
-0.038327105,
-0.120119065,
0.0027732202,
0.01774861,
-0.006896131,
-0.0032214,
0.011031062,
0.0039769523,
0.024754638,
-0.018792644,
0.038327105,
-0.03123865,
-0.0038292762,
-0.0064187595,
-0.02009769,
-0.0071571404,
-0.0030926126,
-0.0025551403,
0.0018184768,
-0.0122880265,
0.04791575,
-0.009533696,
-0.010625812,
-0.0066729,
-0.033354197,
0.02592231,
-0.0056838132,
-0.030551786,
0.027474627,
0.021732429,
-0.000061334955,
-0.0094718775,
-0.018778907,
0.013283982,
0.009911472,
-0.0294528,
-0.026856449,
0.0015780738,
-0.014032666,
0.026774025,
-0.009052889,
-0.025675038,
0.021224149,
0.0055876523,
-0.002100092,
0.010000764,
-0.015550639,
-0.004825231,
0.007850874,
0.011573686,
0.0029878656,
-0.031568345,
-0.017309016,
-0.03272228,
-0.022158286,
0.016045183,
-0.016127605,
0.028092805,
0.039700836,
-0.022529194,
0.0031424104,
0.002414333,
0.0061783567,
0.011305809,
0.0065870415,
0.016127605,
-0.0036094792,
0.0005348966,
-0.030139666,
0.02781806,
-0.025386555,
-0.015097307,
0.024562316,
-0.012906206,
0.011106618,
-0.024438681,
0.0067415866,
-0.04387698,
-0.006875525,
0.0020640313,
-0.022075862,
-0.008173701,
-0.022185761,
0.015440741,
-0.03057926,
0.04132184,
0.009547433,
0.008070672,
-0.00076628453,
0.015688011,
-0.012590248,
-0.013366406,
0.06044418,
-0.013613678,
-0.014643976,
-0.032639857,
0.01585286,
-0.004389072,
0.005934519,
0.008723194,
0.016993057,
-0.027282305,
-0.02699382,
-0.055965815,
0.01947951,
-0.0085240025,
-0.0037399835,
-0.00066454255,
0.0019009007,
0.004598566,
0.020331224,
-0.02970007,
0.028161492,
-0.01048157,
-0.005271694,
-0.036074184,
-0.022831416,
-0.025427766,
-0.03717317,
0.020083953,
-0.0053575523,
0.015097307,
0.012047624,
0.005773106,
0.002184233,
-0.00035717015,
0.01958941,
-0.004863009,
-0.007102191,
-0.015427003,
0.010296117,
-0.007376937,
0.016539725,
0.028010381,
-0.02143021,
-0.019094866,
-0.00090837985,
0.003949478,
0.0036197822,
-0.013064185,
0.023202322,
0.010728842,
0.013297719,
-0.023834238,
-0.016347403,
-0.007246433,
0.017473863,
-0.026980083,
0.02663665,
-0.025304131,
0.014108221,
-0.0017394873,
-0.017460125,
0.035854388,
0.022309396,
0.006714112,
-0.029425325,
-0.003242006,
-0.0064290627,
0.0035510955,
-0.012652066,
0.0038224075,
-0.011580555,
0.008833093,
0.03170572,
0.0080363285,
0.019767994,
-0.010110662,
0.0018184768,
-0.00034407678,
0.0027749373,
-0.009712281,
-0.019039916,
-0.037090745,
0.0030908955,
0.012239946,
0.0027697857,
0.0019094866,
0.005762803,
-0.020083953,
-0.005563612,
-0.011958331,
0.013215295,
0.011347021,
-0.01002137,
-0.020894453,
-0.0006842899,
0.026142107,
-0.025125546,
-0.002362818,
0.0011676716,
0.005206442,
0.0051102806,
0.018023355,
0.02004274,
0.02357323,
0.011092881,
-0.009114708,
0.019520722,
-0.015825385,
-0.00019779585,
-0.012521561,
0.022199498,
-0.014060141,
0.012755095,
0.009190262,
0.000062676496,
-0.01590781,
0.049262006,
-0.02413646,
-0.020564757,
-0.0067003747,
0.0009976724,
0.017322753,
-0.0034583686,
0.028161492,
-0.0008538599,
-0.0042070523,
0.018655272,
-0.008304206,
-0.026238268,
-0.009808442,
0.0044371523,
0.0101244,
0.008352286,
0.0020983745,
0.0007096181,
0.023202322,
-0.020029003,
0.038409527,
-0.0192185,
0.011175305,
0.0043753344,
0.035277423,
-0.00003455793,
-0.014808823,
-0.014795086,
0.011072274,
0.013593071,
0.014753874,
0.029068155,
-0.022103338,
0.085116394,
0.022584144,
-0.022694042,
0.016663361,
-0.03063421,
0.025098072,
0.0064393654,
0.010199955,
-0.027007557,
-0.040167905,
0.0071777464,
-0.0421186,
0.031073803,
-0.0006469416,
-0.017020531,
0.01835305,
-0.017171642,
0.008592689,
-0.011992674,
-0.013806,
0.0059242165,
-0.012610854,
0.0055052284,
0.006786233,
-0.033464096,
-0.0014827712,
0.022968788,
-0.0014819127,
-0.011511869,
0.00014735415,
0.018916281,
-0.010371672,
-0.044728693,
-0.01784477,
0.0031647335,
0.0033810963,
-0.0012303481,
-0.030331988,
0.037942458,
0.0018356486,
0.005975731,
-0.004560788,
0.0048595746,
-0.013599941,
0.008565214,
0.0077890567,
0.026389379,
-0.014959934,
-0.011505
] |
MURR1 is a multifunctional protein that inhibits nuclear factor kappaB (NF-kappaB), a transcription factor with pleiotropic functions affecting innate and adaptive immunity, apoptosis, cell cycle regulation, and oncogenesis. Here we report the discovery of a new family of proteins with homology to MURR1. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions | [
-0.034076296,
-0.012919256,
-0.015203064,
-0.013160362,
-0.03332619,
0.009249089,
-0.01636841,
0.022543399,
-0.0042729317,
-0.025423275,
0.0035998446,
0.0055655274,
0.023976639,
0.019475996,
-0.019127732,
-0.0024445457,
0.026360909,
-0.013073296,
0.0064763715,
0.007628322,
-0.017439991,
0.020601157,
-0.03855015,
-0.044551007,
-0.022007609,
0.030084655,
0.0085525615,
-0.047524646,
-0.012497321,
-0.027030647,
0.0036802134,
-0.013943956,
0.00014137762,
-0.0024880785,
-0.008177508,
0.0070925313,
0.00906826,
-0.023481034,
0.010950225,
-0.022422846,
0.04045221,
-0.0075144665,
-0.00686482,
-0.0025550525,
-0.010822975,
-0.0043432545,
0.007400611,
-0.0049661114,
-0.026293935,
0.02131108,
0.008920917,
-0.004447064,
-0.015618303,
-0.002169953,
-0.012557598,
-0.010575172,
0.00040037808,
0.023601586,
-0.018658916,
-0.01926168,
-0.011385555,
-0.013234033,
-0.024847299,
0.010046078,
0.01375643,
0.010956923,
0.0036333315,
0.0072532683,
-0.013682758,
0.031477712,
0.028771967,
0.040478997,
-0.0057697976,
0.0009979104,
0.027378911,
-0.02105658,
-0.034612086,
0.035924774,
0.00807035,
-0.013160362,
0.012222729,
0.0067107803,
0.0256108,
0.00934955,
0.02394985,
-0.015886199,
0.009255786,
0.013555508,
0.010146539,
-0.0072532683,
0.020949421,
0.013307705,
0.030593656,
0.003941411,
-0.009490195,
0.0057932385,
0.0014650531,
0.027620018,
0.02187366,
-0.026548436,
-0.0061749895,
-0.009456708,
0.00053495367,
-0.009208905,
-0.04216674,
-0.013716245,
-0.012691545,
-0.017761465,
0.023012215,
-0.007112623,
-0.0040787077,
0.033513717,
-0.026923489,
-0.0233069,
0.037291043,
-0.023735534,
0.037719674,
-0.0014039394,
0.0047216564,
-0.009945617,
0.004795328,
0.018632125,
0.002190045,
-0.028316544,
0.020239498,
0.025369696,
-0.003330275,
-0.0021498606,
-0.014185063,
0.004269583,
-0.0018484783,
0.012899164,
0.02577154,
-0.004142333,
-0.0037203976,
-0.0019573108,
-0.0128656775,
0.0010548382,
-0.007876125,
-0.0020946073,
0.024592798,
0.041363053,
-0.029923918,
-0.02161916,
-0.0044269715,
0.005023039,
0.025302721,
-0.0047216564,
0.013970746,
0.011532897,
0.0061415024,
-0.02133787,
0.0256108,
-0.008673114,
0.007963191,
0.0121557545,
-0.0037337923,
0.029066652,
0.0019757287,
-0.009001286,
0.00035831012,
-0.016381804,
-0.002320644,
0.0015671882,
0.0052005197,
0.024780326,
0.014238642,
-0.0068279845,
-0.008887431,
-0.0058032842,
0.03195992,
0.012731729,
-0.033808403,
0.005538738,
-0.0036232856,
0.00043239995,
0.0080569545,
0.03142413,
-0.024378482,
0.0078426385,
0.006730872,
0.0019271726,
0.029227389,
-0.00007053184,
-0.0060544363,
-0.01009296,
0.0128656775,
-0.005317724,
-0.0028748526,
-0.0069920705,
-0.005444974,
0.013582298,
-0.000026841864,
-0.011097567,
-0.6313759,
-0.018712495,
0.028798757,
-0.00038635542,
-0.01754715,
0.035924774,
0.015484354,
-0.012309794,
-0.0072063864,
0.028905915,
-0.015859408,
0.021284292,
-0.01841781,
-0.0373982,
-0.042006,
-0.040023576,
-0.031772397,
-0.020078762,
0.018792864,
-0.015109302,
0.00082419696,
0.0011176262,
-0.0017036474,
0.007112623,
-0.023856087,
0.014385983,
0.019502787,
-0.012731729,
0.0069250963,
0.01662291,
-0.02633412,
0.026200172,
0.0122093335,
-0.00056299893,
0.05502572,
-0.021739712,
-0.0026655593,
0.014533326,
0.022757715,
0.02622696,
-0.0001431566,
-0.0048321635,
0.036915988,
0.0042963726,
-0.020480605,
0.020453814,
0.0053545595,
0.019127732,
0.0074274004,
-0.008686509,
-0.0078426385,
0.013796614,
-0.018404415,
-0.010889948,
0.015337013,
0.011472621,
0.025650986,
-0.025624197,
-0.0021883706,
0.00034114806,
-0.014305615,
0.007105926,
-0.010689027,
-0.011686938,
-0.016716674,
0.001967357,
-0.0071729,
0.004741749,
0.001962334,
0.0059941597,
0.008820456,
0.031075869,
0.009148628,
0.005655942,
0.009336155,
0.036487356,
0.0025734704,
0.028905915,
0.017359624,
0.016890805,
0.00208791,
-0.023226533,
-0.027164595,
-0.010200118,
0.018243678,
0.017560543,
-0.016917596,
0.021458423,
0.005428231,
-0.0029954056,
0.0011251607,
-0.03568367,
-0.008740088,
-0.015698671,
-0.016609516,
0.019342048,
-0.0051067565,
0.0035730551,
-0.0018819653,
-0.024445457,
-0.0021163737,
-0.012108873,
0.009275879,
-0.007748875,
0.008130626,
-0.0034491534,
-0.02400343,
0.014385983,
0.050525077,
-0.0112248175,
0.0003930528,
0.018511573,
0.01757394,
-0.017038148,
-0.0039045757,
-0.013508626,
0.028718388,
0.00655674,
0.017439991,
-0.020962816,
0.010146539,
-0.011840978,
0.033674452,
-0.019931419,
0.012202636,
0.018538363,
0.007701993,
-0.009028075,
-0.0051670326,
-0.021431632,
0.027807543,
-0.011928043,
0.013019717,
-0.00919551,
0.024860695,
0.008425311,
0.023909666,
0.011077476,
0.0146136945,
-0.026293935,
-0.020788684,
-0.029066652,
0.006462977,
-0.020560972,
-0.009523682,
-0.007943099,
-0.016113909,
0.0055487836,
-0.00024591963,
-0.007628322,
0.0035964958,
0.013796614,
0.0014859823,
0.00032231168,
0.0071394127,
-0.010662237,
-0.026133198,
-0.0042863265,
-0.016006751,
-0.012925954,
-0.0033905513,
0.008036862,
-0.02487409,
0.0055420864,
0.0067811026,
0.00027501138,
0.0073068473,
0.015015538,
0.007219781,
-0.04144342,
-0.014841406,
-0.0028614579,
-0.035790827,
0.0019154522,
0.00032000945,
0.018029362,
-0.011465924,
-0.006014252,
-0.01718549,
-0.0012632943,
-0.0028614579,
-0.012195938,
-0.017788256,
-0.013676061,
0.03563009,
0.031209815,
0.031906344,
0.003958155,
0.0062252195,
0.015658487,
-0.012584387,
0.0063290293,
-0.013957351,
0.033460137,
0.011291792,
-0.025517039,
0.02392306,
0.001160322,
-0.0026823028,
0.026535042,
-0.0047886306,
-0.034129877,
0.0041222405,
-0.01923489,
0.015136091,
-0.014158272,
0.004239445,
-0.01861873,
0.011325278,
-0.004075359,
-0.0073336367,
0.0025366347,
-0.01926168,
-0.023708744,
-0.009637537,
0.026280541,
-0.005053177,
-0.00038740187,
-0.014305615,
-0.032361764,
0.015939778,
0.014064509,
0.021324474,
0.007768967,
0.005451672,
0.0017346228,
-0.0066940365,
0.014894985,
-0.0081105335,
-0.0055588298,
0.0019874491,
0.011258305,
0.015042327,
0.0053244215,
-0.013642574,
0.0016559286,
-0.013086691,
-0.030218603,
0.038871624,
0.0059539755,
0.0076685064,
0.0022854828,
-0.007474282,
0.006245312,
0.016877411,
-0.027673597,
0.009255786,
-0.007815849,
0.004413577,
0.017131912,
-0.004597755,
0.021190528,
-0.01805615,
-0.0059975088,
0.010287184,
-0.0082779685,
0.003209722,
-0.0076885982,
0.051864553,
0.014493142,
0.028932706,
-0.015122696,
0.027231568,
-0.008512377,
0.007628322,
0.017453386,
0.0055286917,
-0.033486925,
-0.017131912,
-0.014479747,
-0.033728033,
0.012082083,
0.009095049,
-0.0286916,
0.010970317,
0.021069974,
0.015591513,
0.03734462,
0.004293024,
-0.008244481,
-0.019074153,
-0.022637162,
0.029093442,
0.017105123,
-0.013635877,
-0.016917596,
-0.03453172,
-0.009423221,
-0.015537934,
0.0143458,
0.0018953601,
0.004775236,
-0.0026772798,
0.018846443,
-0.0023306902,
0.013522021,
0.03212066,
-0.038818046,
0.013495231,
-0.02248982,
0.0042026094,
-0.024365088,
0.010180025,
0.0033386466,
0.016810438,
0.012015109,
0.008867338,
-0.00015759785,
-0.0053545595,
-0.0047685383,
-0.00089075224,
0.00078443123,
0.020547578,
0.0029552213,
-0.0012992928,
-0.0014257059,
0.026173381,
0.007802454,
-0.015886199,
0.015926382,
-0.006647155,
-0.036005143,
0.005491856,
-0.009764788,
0.018216887,
0.024632983,
-0.0033352978,
0.013629179,
-0.0014524955,
-0.0069585834,
-0.014961959,
-0.0256108,
0.017506965,
-0.009918828,
-0.016274646,
0.004902486,
-0.014868195,
0.0060644825,
0.018149914,
0.007829243,
-0.00007665367,
-0.027258359,
-0.01283219,
0.0045374786,
0.032763608,
-0.019475996,
0.016971175,
0.031799186,
0.007822546,
-0.004517386,
0.0128656775,
0.047578227,
-0.0036400289,
-0.034960352,
0.020145735,
-0.017172096,
0.011573082,
0.00835164,
-0.020895842,
-0.015698671,
0.023226533,
0.017922204,
-0.010334065,
-0.008746785,
0.015417381,
0.00014640066,
0.0067476155,
-0.010146539,
0.001759738,
-0.014787827,
-0.009758091,
-0.0019807518,
0.009871946,
-0.0012482252,
0.010970317,
-0.018203493,
-0.019060759,
-0.020869052,
0.011425739,
-0.00937634,
0.0107894875,
0.023025611,
-0.011479318,
-0.032870766,
-0.017373018,
-0.016555937,
0.01580583,
-0.000010896332,
0.0065969247,
0.0010858136,
-0.01718549,
-0.0153236175,
-0.025208957,
-0.008090441,
0.020895842,
-0.039809257,
-0.017131912,
0.007695296,
0.015886199,
0.037371412,
0.009671024,
-0.016890805,
-0.00031038196,
0.019114338,
0.0025634242,
-0.0018116428,
0.0073939133,
-0.029709602,
-0.006550043,
-0.012631269,
-0.0022653907,
-0.017373018,
-0.017868625,
0.0015403986,
-0.020279683,
0.006295542,
0.013850193,
0.0031896299,
-0.026173381,
0.01360239,
0.024472246,
0.0073738215,
-0.001890337,
0.00038991342,
0.013053204,
-0.020011788,
-0.012296399,
-0.03254929,
0.00041984234,
-0.016797042,
0.017145306,
0.015966566,
-0.015363802,
0.007802454,
0.01861873,
0.011345371,
0.0010171654,
-0.0032030246,
-0.006362516,
0.025155379,
0.005739659,
0.0074474923,
-0.010910041,
-0.009302668,
-0.015457565,
0.0007111786,
0.007936401,
0.02925418,
-0.008284666,
0.023936456,
-0.014787827,
-0.009650933,
-0.00023461778,
-0.008378429,
-0.019208102,
0.032067083,
0.011238213,
-0.011285095,
-0.019703709,
-0.010340763,
-0.007641717,
-0.0028296453,
-0.007387216,
-0.00020866541,
-0.0077153877,
-0.0072867554,
0.013876982,
-0.013247428,
-0.0034173408,
-0.020654736,
-0.011265002,
0.012162452,
0.02248982,
-0.0019489392,
-0.009115142,
0.00002235514,
-0.024646377,
-0.016515752,
-0.024324903,
-0.056258038,
0.00045918947,
-0.01124491,
0.05947278,
0.016636305,
0.028504072,
0.015939778,
0.009838459,
0.03195992,
0.01875268,
-0.01549775,
-0.0008740088,
-0.00067434297,
-0.024606194,
0.017413203,
0.015658487,
-0.011974925,
0.012919256,
-0.0083851265,
0.010822975,
0.024365088,
-0.008853943,
-0.0021331173,
-0.0071929917,
-0.02540988,
-0.029388126,
-0.0118811615,
-0.036674883,
0.010715816,
-0.033433348,
-0.0020376795,
0.03265645,
0.008565956,
0.013394771,
0.004088754,
0.016730068,
-0.014707458,
0.020172525,
-0.0078962175,
0.017480176,
-0.011787398,
0.013655969,
0.0028966193,
-0.004862302,
0.013160362,
-0.007742177,
0.012008412,
0.008559259,
-0.024137376,
0.010086263,
-0.0125509,
-0.027097622,
-0.018538363,
0.018350836,
-0.0011963204,
-0.035362195,
-0.013595692,
-0.004423623,
-0.052641448,
0.025302721,
-0.00399499,
-0.02364177,
0.011539595,
0.0018836396,
-0.003122656,
0.03102229,
-0.0030004287,
0.0407201,
-0.030084655,
0.03388877,
0.01956976,
-0.0035496142,
-0.010260395,
0.001977403,
0.0060510878,
-0.0008174996,
0.039434206,
0.032442134,
-0.008398521,
0.00039535502,
0.004838861,
-0.00284304,
-0.019435812,
-0.034612086,
0.02282469,
-0.0002337806,
0.024204351,
-0.003563009,
-0.0133211,
-0.010508197,
-0.013501929,
-0.010943527,
-0.005679383,
0.004838861,
-0.012296399,
-0.013247428,
0.010153236,
-0.009316063,
-0.0065332996,
-0.0010146538,
-0.0473907,
0.0017882019,
-0.033379767,
0.008900825,
-0.022985427,
0.008860641,
0.036594514,
0.015685277,
-0.010568474,
0.020319868,
0.0054717637,
0.006690688,
-0.00007838034,
-0.021632554,
0.036996357,
0.011619964,
-0.0030188465,
-0.0036031932,
-0.0077756643,
0.015899593,
-0.026012644,
-0.010709119,
-0.021512002,
-0.023990035,
0.005555481,
0.0117204245,
0.014171667,
-0.01375643,
0.028477283,
-0.01995821,
-0.010072867,
-0.023896271,
-0.016234461,
0.013796614,
-0.04090763,
-0.019757288,
-0.010534987,
0.020333262,
0.020547578,
0.019944813,
0.0076752035,
-0.0010464664,
0.044604585,
-0.03557651,
0.012108873,
0.0012348305,
-0.01139895,
-0.011318581,
0.031075869,
-0.0038442991,
-0.045997642,
0.007976586,
-0.023467638,
-0.037291043,
-0.007353729,
-0.03281719,
0.009188812,
0.013863588,
-0.011593174,
0.030459708,
-0.018297257,
-0.009557169,
0.0037337923,
0.017064938,
0.022074582,
-0.024110587,
0.013347889,
0.009255786,
-0.0013461745,
-0.008445403,
0.000754293,
-0.014091299,
0.013930562,
-0.008612838,
-0.014211852,
-0.017908808,
-0.013796614,
-0.019221496,
0.0038576939,
-0.00525075,
-0.0010841392,
-0.028289756,
0.0065232534,
0.006754313,
-0.010869856,
-0.023333691,
0.0026354212,
-0.011928043,
0.0022921802,
-0.01788202,
-0.01931526,
0.00076224614,
-0.040988,
-0.013414863,
0.009918828,
-0.032254606,
0.033567294,
-0.0078426385,
-0.010474711,
-0.028129019,
0.008780272,
-0.040478997,
-0.02248982,
-0.018551758,
0.028209386,
0.004135635,
0.025637591,
-0.009061563,
0.005521994,
-0.0038610427,
0.008137323,
0.02656183,
-0.019810867,
0.012644663,
-0.0037605818,
0.022168346,
-0.013033112,
-0.024552615,
-0.027646806,
0.036674883,
-0.005079967,
-0.009289273,
0.044015218,
-0.041202314,
0.014412773,
-0.008237784,
-0.0077086906,
-0.0037070028,
0.020534184,
0.03619267,
0.00026915118,
-0.040478997,
-0.0011820885,
0.008405219,
-0.0037974175,
0.010226907,
0.02622696,
0.016194278,
0.0071327155,
-0.004771887,
-0.013970746,
0.016100515,
-0.02139145,
0.03734462,
0.023681955,
0.009543774,
0.0020343307,
0.007313545,
-0.021739712,
-0.025838513,
-0.015015538,
-0.012323189,
-0.012403558,
0.008693206,
0.019248286,
-0.020266289,
-0.0034792917,
-0.018792864,
-0.01667649,
-0.010990409,
-0.026267145,
-0.0061816867,
-0.008164112,
-0.00981167,
-0.021578975,
-0.007641717,
-0.018712495,
-0.014921774,
-0.013863588,
-0.0020092155,
0.009074957,
-0.027861124,
-0.0026655593,
-0.009979105,
-0.0015253295,
-0.0078091514,
-0.0037739766,
0.0013445001,
-0.0060879234,
0.002422779,
0.026347514,
0.19556366,
-0.01080958,
0.0019489392,
0.009074957,
-0.0056057116,
0.0054952046,
0.0043733926,
-0.018015966,
-0.0032113963,
0.0146136945,
-0.00004800665,
0.008653021,
-0.016917596,
-0.0021599068,
0.014694063,
0.0020828869,
-0.020761894,
-0.011131055,
-0.037183885,
0.0010171654,
0.022476425,
0.0029451752,
0.012798703,
-0.0019204753,
0.025061617,
0.028343335,
-0.0075144665,
0.009054865,
0.012416952,
0.0080033755,
-0.027566439,
-0.010247,
-0.007119321,
0.0022570188,
0.003069077,
0.019784076,
-0.008699903,
-0.0029301061,
0.00015519098,
0.00730015,
-0.014734248,
0.022998821,
0.002262042,
0.0037404897,
-0.0031946527,
0.009275879,
-0.009570563,
0.0037538845,
-0.0005709521,
0.0020226103,
-0.048944492,
0.026133198,
0.004410228,
0.021096764,
0.0035998446,
-0.015484354,
-0.010367553,
0.005451672,
0.0075144665,
0.003891181,
-0.016569331,
-0.016663095,
-0.05081976,
0.03568367,
-0.027271753,
0.037639305,
-0.012490624,
0.0007141087,
0.012015109,
-0.03498714,
-0.020092156,
0.006985373,
-0.020386841,
-0.002571796,
0.010601961,
-0.0033620875,
0.0048221173,
0.024445457,
0.023789113,
0.023440849,
0.015899593,
-0.022637162,
-0.061401628,
0.021994213,
0.0012532482,
-0.03142413,
-0.008432008,
0.010233604,
-0.0082243895,
-0.033433348,
0.0021766503,
0.01295944,
-0.0032699984,
-0.0104613155,
0.010046078,
0.02102979,
-0.0075278613,
-0.009322761,
-0.001029723,
-0.011298489,
-0.041898843,
0.05947278,
-0.004698216,
0.00863293,
-0.017279254,
0.0041858656,
-0.0065433453,
0.004751795,
-0.0004116799,
-0.002310598,
0.0111176595,
-0.017105123,
-0.016756859,
0.0050062956,
-0.008425311,
0.003780674,
0.014332404,
-0.026856516,
0.017252464,
-0.007856033,
0.008445403,
-0.025517039,
-0.006700734,
0.021860266,
-0.021150343,
0.005920489,
0.0015830945,
0.0046915184,
-0.004761841,
-0.03750536,
0.0082243895,
-0.011365463,
0.019529575,
0.011907951,
0.025731355,
-0.0047350517,
0.023481034,
-0.0064663254,
-0.0012264587,
0.026735961,
-0.030218603,
-0.014506537,
0.006898307,
-0.00009627491,
-0.030807972,
-0.020199314,
0.019342048,
0.04776575,
-0.0146136945,
0.019033968,
-0.000114588074,
-0.012892467,
-0.008103836,
-0.027914703,
0.022811294,
-0.039460994,
-0.0059774164,
-0.035710458,
-0.00031435853,
-0.012517413,
-0.011700332,
-0.0014005908,
0.014653879,
-0.0031092612,
-0.012108873,
0.010059473,
-0.16898842,
-0.002769369,
0.011084173,
-0.0069250963,
0.025316117,
0.02044042,
-0.0056391982,
-0.00011678565,
-0.0066069704,
-0.015899593,
0.02257019,
-0.0043834387,
-0.023025611,
-0.03394235,
-0.0037974175,
-0.00847889,
0.015444171,
0.0397021,
-0.00025701217,
0.0153236175,
0.056954566,
-0.01139895,
-0.0035596604,
-0.012390163,
0.009530379,
0.009744695,
0.0055487836,
-0.007929704,
-0.020065367,
-0.001561328,
-0.0035228247,
0.006720826,
0.035924774,
-0.005143592,
0.033460137,
-0.00049518794,
0.015444171,
-0.012202636,
0.004594406,
0.0058870018,
0.009309365,
0.009168721,
0.0014139855,
0.0071929917,
-0.024244536,
0.013220639,
-0.0038309044,
-0.0036031932,
0.016261252,
-0.012236123,
0.016301436,
-0.015859408,
0.00827127,
0.004128938,
0.03624625,
-0.006603622,
0.008237784,
0.001266643,
-0.034263823,
-0.011258305,
-0.0230524,
-0.00073880533,
0.023320295,
0.013274218,
0.004946019,
-0.025329512,
-0.018498179,
0.02102979,
-0.033567294,
0.0058903503,
-0.023534613,
0.0064060492,
0.024753537,
-0.016261252,
0.018069545,
0.01575225,
-0.009731301,
0.020145735,
-0.014761037,
0.016837226,
-0.0041222405,
0.009342853,
-0.022784505,
-0.032254606,
0.0014106368,
0.007494374,
0.011901254,
0.0041691223,
0.0028447143,
-0.013702851,
0.011512806,
-0.038309045,
-0.009764788,
-0.0010523266,
0.031718817,
0.021163737,
-0.024391877,
-0.0048957886,
-0.010280486,
-0.011988319,
0.020494,
-0.010796186,
-0.0012750147,
-0.011941438,
0.04080047,
-0.008016771,
0.0034960352,
0.00798998,
0.032334976,
-0.029602444,
0.011365463,
-0.00056676625,
0.011633358,
0.027285147,
-0.0024545917,
-0.007474282,
0.010816277,
-0.007501072,
-0.0057999357,
-0.016421989,
0.083208315,
0.016904201,
0.0034792917,
-0.005753054,
-0.019114338,
-0.02187366,
-0.1201243,
-0.005676034,
0.009965709,
0.013153665,
-0.04085405,
0.011506108,
-0.0065466943,
0.029414916,
0.016797042,
0.02369535,
-0.010668935,
0.0043198136,
0.0031779094,
-0.0040854053,
0.0135756,
0.0010129795,
0.018900022,
-0.011157844,
-0.015926382,
0.024391877,
0.0025316116,
-0.020199314,
0.013863588,
-0.0072398735,
0.012946046,
0.00701886,
-0.029682811,
0.0253563,
0.009664327,
0.013106783,
-0.00212642,
-0.0060711796,
0.030406129,
0.0052775396,
-0.012182544,
0.0033152057,
-0.011633358,
-0.01431901,
0.01662291,
-0.0072398735,
0.0037203976,
0.0016676489,
0.0015621651,
-0.0029736392,
0.012952743,
-0.008472192,
-0.0057363105,
0.014064509,
0.019918025,
-0.012872375,
-0.013187151,
-0.018524967,
-0.041711316,
-0.007561348,
0.018243678,
-0.010943527,
0.021940634,
0.038844835,
-0.029897127,
0.0068145897,
0.0005085827,
-0.0018334092,
-0.023105979,
0.028584441,
0.032442134,
-0.0008731716,
0.004159076,
-0.014720853,
0.02712441,
-0.015122696,
-0.009563866,
-0.003137725,
0.00047509576,
0.0016333249,
-0.020065367,
0.0146672735,
-0.017172096,
-0.025329512,
0.014412773,
-0.035201456,
-0.008833852,
-0.013267521,
0.012718335,
-0.0042561884,
0.019368839,
0.015859408,
0.003368785,
-0.007105926,
0.00701886,
-0.020011788,
-0.005016342,
0.0507126,
0.017560543,
-0.0066538523,
0.000010785145,
0.014546721,
0.014988748,
0.0013143619,
0.009778183,
0.022610374,
-0.026709173,
-0.003224791,
-0.06836691,
0.011131055,
0.018578546,
-0.00008936824,
0.02804865,
-0.001489331,
0.018725889,
-0.0024278022,
0.008036862,
0.03437098,
-0.01597996,
0.007226479,
0.00079740747,
0.003147771,
-0.024847299,
0.004293024,
0.03332619,
0.0038108123,
0.035362195,
0.026360909,
0.0036165882,
-0.012082083,
0.02686991,
0.0020946073,
-0.0050062956,
-0.0077622696,
-0.03324582,
0.0047886306,
0.0032281398,
0.012363373,
-0.007313545,
-0.030057866,
-0.016944384,
0.01867231,
-0.009309365,
-0.029388126,
-0.0023892922,
0.026267145,
0.013033112,
0.020266289,
-0.02695028,
-0.035121087,
0.0060075545,
0.0053076777,
0.025262538,
-0.007876125,
-0.03037934,
0.032576084,
0.0034893379,
-0.028771967,
0.03855015,
0.004172471,
-0.00847889,
-0.01898039,
-0.021940634,
0.004118892,
0.005676034,
-0.028584441,
-0.013006322,
-0.025825119,
0.009671024,
0.025838513,
0.014479747,
0.016743463,
0.0020075412,
-0.01606033,
-0.030111445,
-0.0184446,
0.03621946,
-0.018015966,
-0.0042260503,
-0.004018431,
0.010139842,
-0.003060705,
0.019033968,
-0.012979533,
-0.021471817,
0.0039916416,
-0.035871197,
0.020962816,
0.016743463,
0.0007990818,
-0.015926382,
0.018739285,
0.015899593,
-0.022168346,
-0.010668935,
0.010046078,
0.03271003,
0.0139037715,
-0.014774432,
0.010722514,
0.0108966455,
-0.011981622,
0.008673114,
0.0020527486,
0.0008015933,
-0.0082779685,
0.013716245,
0.03383519,
-0.0004370044,
-0.011104265,
-0.014439562,
-0.0068581225,
-0.014935169,
0.01344835,
-0.025182169,
-0.04564938,
-0.031209815,
-0.001561328,
0.014252036,
0.0087132985,
-0.00468817,
0.006777754,
-0.00252324,
0.012825493,
0.0116065685,
0.0124303475,
-0.0059405807,
0.027834333,
0.018498179,
0.015122696,
0.002571796,
-0.0058903503,
0.002832994,
0.025905486,
0.0050364337,
-0.0028346684,
0.041630946,
-0.018270466,
0.010722514,
0.0009133559,
-0.003650075,
-0.013957351,
-0.022610374,
-0.0007718737,
0.026521645,
0.00096023764,
-0.009202207,
0.0745285,
0.014185063,
-0.026883304,
-0.0016190929,
0.0045140376,
0.020333262,
0.0066404575,
-0.014305615,
-0.0029351292,
-0.019931419,
-0.0043834387,
-0.003171212,
0.0044838996,
-0.04902486,
-0.041764896,
0.030861551,
-0.014546721,
0.03037934,
-0.0006128108,
-0.04096121,
0.014305615,
-0.0042126556,
-0.012611177,
0.0034089691,
-0.03402272,
0.0030104746,
0.048623018,
-6.9328405e-7,
0.003224791,
-0.024847299,
0.014854801,
0.0009175418,
-0.0053880466,
-0.008894128,
0.015712066,
-0.019087547,
-0.00046044524,
-0.004239445,
0.0001938056,
0.031825975,
-0.011506108,
-0.00045123632,
-0.030004287,
-0.01093683,
0.030647235,
0.004564268,
-0.033808403,
-0.0026002598,
-0.013367981
] |
To define the genetic changes of flat urothelial lesions, carcinoma in situ (CIS) and moderate dysplasias (DII) were investigated for alterations in the two chromosomal regions most frequently involved in bladder cancer. Overall, 33 CIS and 16 DII from 21 patients were used to microdissect urothelium. Dual color fluorescence in situ hybridization (FISH) using gene locus probes of 9q22 (FACC), 9p21 (CDK), 17p13 (p53), and related centromeric probes was applied on interphase nuclei. In parallel | [
-0.011731968,
0.012716283,
0.021295782,
-0.019367058,
-0.055866513,
0.018688679,
-0.030726582,
0.0069500604,
-0.01956658,
0.003047718,
0.008978547,
0.011658809,
-0.0010084239,
0.026855832,
-0.0038275213,
0.0033137489,
0.021322386,
0.011499191,
0.0086327065,
-0.016853064,
-0.038042437,
0.011253112,
-0.0005432852,
-0.0048417645,
-0.01594856,
0.026696213,
0.01689297,
-0.026297167,
-0.006670728,
-0.0013393,
-0.00062101614,
0.012563315,
-0.02555228,
-0.020072041,
-0.014937642,
0.020377977,
0.025938025,
0.0002602116,
0.022732351,
-0.020803625,
0.018795092,
0.0013118655,
-0.021947559,
0.005220859,
-0.0013733851,
0.013740502,
-0.0031408288,
0.00048675362,
-0.014019835,
0.015749035,
0.00015213649,
0.031178836,
-0.022479622,
-0.0019503399,
-0.009144817,
-0.013215091,
0.04048992,
0.0052674143,
-0.01612148,
-0.006697331,
-0.008699214,
-0.010242194,
-0.013521027,
0.029316619,
-0.025139932,
-0.0006376431,
0.015735734,
0.0030128013,
0.02186775,
-0.0028714724,
0.03628663,
0.02958265,
0.0032871459,
-0.02788005,
0.04150084,
-0.0011730305,
-0.020125246,
-0.010588035,
0.0031790708,
0.021282481,
0.017903887,
-0.014804626,
-0.019167535,
-0.006983314,
0.011605604,
0.025193138,
0.010588035,
0.013028869,
-0.012869251,
-0.005593302,
-0.0054835645,
0.03852129,
0.006494482,
0.011725317,
-0.024408346,
0.009284482,
-0.0083001675,
0.03359972,
0.0007602668,
-0.037536975,
-0.0038574499,
0.0047985343,
-0.024940409,
-0.015456402,
-0.012895853,
0.001981931,
0.018090108,
-0.016587034,
0.008712516,
-0.012569966,
-0.006421324,
0.030566964,
0.012436951,
-0.03697831,
0.031524677,
-0.023543745,
0.0029629206,
-0.0050978195,
-0.0067006564,
-0.00078312884,
0.0020717166,
0.0038707512,
0.02435514,
-0.020098643,
0.03801583,
0.00917142,
-0.023969395,
0.026403578,
-0.0060754833,
-0.011539095,
0.0045158765,
-0.004698773,
0.0274544,
0.004904947,
-0.010747653,
-0.025831612,
-0.018396044,
-0.018555664,
-0.01774427,
-0.04062294,
0.012290633,
0.033573113,
-0.024873901,
0.022000765,
0.0063913953,
0.00746217,
0.008931992,
0.008772373,
-0.008719167,
-0.014405579,
0.0061619435,
-0.018529061,
0.008140549,
-0.009597069,
-0.007581884,
0.042910803,
-0.007502075,
0.017677762,
-0.021575116,
-0.006245078,
-0.015123864,
0.011246461,
0.008027486,
0.013940025,
0.019327154,
0.022333303,
0.020923339,
0.014911039,
-0.0056997146,
-0.0056731114,
-0.010887319,
0.01020229,
-0.023131397,
0.023876283,
0.005144375,
0.00089286664,
-0.012729584,
0.003508284,
-0.03498308,
-0.018076807,
-0.039851446,
0.01988582,
0.019912422,
-0.0034184987,
-0.020896737,
-0.011997999,
0.020963244,
-0.0067372355,
-0.032003533,
-0.010149083,
-0.0006945904,
0.012629823,
-0.0021930933,
-0.0066075455,
-0.63847446,
-0.039851446,
0.012842648,
-0.0091913715,
0.011199906,
0.050865132,
-0.0062583797,
-0.013068774,
0.0005125254,
0.0029529443,
-0.02734799,
0.014804626,
0.003036079,
0.010215591,
-0.013168535,
-0.028545128,
-0.011459286,
-0.012277331,
0.023743268,
-0.0039006798,
0.00015244825,
0.011718666,
0.008672611,
0.0123637915,
0.01106689,
0.03147147,
0.011505841,
-0.028545128,
0.032216355,
0.0079676295,
-0.026390277,
0.011971395,
-0.01706589,
-0.015456402,
0.04080916,
-0.008466437,
-0.007495424,
0.012450252,
0.023969395,
0.037696596,
-0.010741002,
-0.016307702,
0.021827845,
-0.002226347,
-0.01731862,
0.024235426,
0.022027368,
-0.007621789,
0.02367676,
-0.004835114,
0.011206557,
0.00055243005,
-0.005470263,
-0.018635472,
0.03482346,
-0.0035714665,
0.03543533,
-0.017212206,
0.0138735175,
0.0013052147,
-0.008626056,
0.01637421,
-0.0043163532,
-0.009510609,
0.020058738,
0.016773256,
-0.026869133,
-0.00014049764,
0.019140933,
0.025525676,
0.016786557,
0.031019216,
-0.0018489156,
-0.004442718,
0.019313851,
0.04418775,
-0.0031707573,
0.008592802,
-0.011053589,
0.009477355,
0.014099644,
-0.011432683,
-0.023849681,
0.019154234,
0.0075951857,
-0.006088785,
-0.011579,
0.02427533,
-0.011971395,
-0.0055367704,
0.012569966,
0.0017425031,
-0.01354763,
-0.0411816,
-0.024993613,
0.027933257,
-0.005856008,
0.0059291665,
0.0066574262,
-0.043549277,
-0.013308202,
-0.008905388,
-0.018196521,
0.014857832,
0.011632206,
0.018715283,
-0.031923722,
0.010847415,
0.01586875,
-0.020963244,
0.011000383,
0.0008646008,
-0.00994291,
-0.008732468,
0.00023797306,
-0.025060123,
-0.009543863,
0.01870198,
-0.0023493865,
-0.011632206,
0.005393779,
0.01423266,
0.012709632,
-0.03780301,
0.008878785,
0.008872135,
0.008772373,
-0.01766446,
0.0025821635,
-0.022426415,
0.013414614,
-0.01723881,
0.031604484,
-0.025193138,
-0.01388682,
-0.011086843,
0.028092876,
0.0036246725,
-0.01492434,
-0.0145785,
-0.03713793,
-0.01689297,
0.021122864,
0.008685913,
-0.011419382,
-0.0019187487,
-0.022053972,
-0.0020018835,
0.0023610252,
-0.019154234,
-0.00565981,
-0.0125899175,
-0.02899738,
0.02196086,
0.016028369,
0.009836497,
0.005706365,
-0.018223125,
0.0029778846,
-0.02238651,
0.004851741,
0.008326771,
0.008838881,
-0.01131962,
-0.0012096098,
-0.0011480901,
-0.008699214,
-0.0077481535,
-0.027374592,
-0.025951326,
0.0037676643,
0.0038873784,
-0.0065410375,
0.009244578,
0.001243695,
-0.014339072,
-0.0065476885,
-0.005606604,
-0.008838881,
-0.017784175,
0.0042830994,
-0.0085262945,
-0.020085342,
-0.0008853845,
0.015044054,
0.02520644,
0.014950943,
0.0011090168,
0.011007033,
0.021202672,
-0.0055168183,
0.00865931,
0.004349607,
0.023969395,
0.0005719667,
0.016254496,
0.026190754,
-0.018063506,
0.0010865704,
0.031444866,
0.036206823,
-0.008765722,
0.01552291,
-0.014019835,
0.02153521,
-0.027201671,
0.009497307,
-0.0097500365,
0.018595569,
0.015044054,
0.018795092,
0.0058460315,
-0.010741002,
-0.003910656,
-0.0075685824,
-0.000896192,
0.010009417,
-0.015177069,
-0.0006106243,
0.010322004,
0.0039838147,
0.025512375,
0.04110179,
0.006497808,
-0.004349607,
0.0048816693,
-0.0015945234,
0.0039904653,
0.017198905,
-0.00225295,
-0.00737571,
0.023570348,
0.012470204,
0.01012248,
0.014671611,
0.0057362937,
0.016480621,
-0.005706365,
0.024594568,
0.007728201,
0.01423266,
0.015589418,
-0.0026736117,
-0.00057737046,
0.03181731,
-0.0022961802,
0.020484388,
0.016986081,
-0.023277715,
0.0045491303,
0.0036313233,
0.004692122,
-0.0030676702,
-0.009936258,
-0.0007519533,
-0.01020894,
0.0073557575,
0.024301933,
0.04304382,
-0.011293016,
0.01569583,
0.0012985639,
-0.00021490318,
0.002803302,
-0.019061122,
0.01586875,
0.008626056,
-0.025166534,
-0.0120911095,
-0.0005590808,
-0.010967129,
0.0063913953,
0.006930108,
-0.019167535,
0.005653159,
0.009497307,
0.0052308347,
0.00071662106,
0.015709132,
0.00728925,
-0.012370442,
-0.027560813,
0.03437121,
0.018648775,
-0.00806074,
0.004306377,
-0.0009868088,
0.011306318,
-0.0010366896,
0.016826462,
0.010827462,
0.014857832,
0.012377094,
0.013368059,
0.0014490377,
-0.012909155,
0.008246962,
-0.029662458,
0.003963862,
0.01664024,
0.00053455605,
0.004123481,
-0.017225508,
0.009477355,
0.034530826,
0.016493924,
0.0031192137,
0.00047802448,
-0.019047821,
-0.03806904,
-0.003997116,
-0.027294783,
-0.0265898,
-0.0004892477,
-0.021362292,
-0.020284865,
0.006654101,
-0.0029147023,
0.038228657,
-0.0018672053,
-0.022320002,
-0.03868091,
-0.017797476,
-0.017265413,
0.011672111,
0.0197262,
-0.011539095,
0.020644007,
0.02410241,
-0.009590418,
-0.0074821226,
-0.040436715,
0.0043861866,
-0.01999223,
-0.012643124,
0.0105813835,
0.00047386775,
-0.002482402,
0.022665843,
0.029343221,
0.0049814307,
-0.029050587,
-0.00746217,
0.019074423,
-0.022399811,
0.0027949885,
0.044932637,
0.029768871,
0.022200288,
-0.017704364,
0.022532828,
0.014485389,
0.014937642,
-0.016400812,
-0.039292783,
0.019939024,
0.0069168066,
0.023623554,
-0.01947347,
-0.024767488,
0.014112946,
-0.014405579,
0.015044054,
-0.00024233763,
0.0071229804,
0.0061719194,
0.022147082,
0.0008188767,
0.008612754,
-0.025166534,
-0.009856449,
0.013328154,
-0.008712516,
-0.012337188,
0.0047220504,
-0.024820695,
0.0123637915,
-0.01766446,
0.03240258,
0.00061976915,
-0.00045765648,
-0.023969395,
0.0049448516,
-0.016480621,
0.010002767,
-0.008486389,
0.0153233865,
-0.0039173067,
-0.017597951,
-0.024820695,
-0.002623731,
-0.002889762,
-0.039931256,
-0.008592802,
0.006551014,
-0.028704748,
-0.03806904,
-0.009158118,
0.016493924,
0.007947677,
0.016613638,
-0.0069367588,
0.0038840529,
0.02777364,
-0.0051942556,
-0.01552291,
0.014897737,
-0.023956094,
0.004891645,
0.015030753,
0.014698214,
-0.004968129,
-0.024009299,
0.021668227,
0.0050180103,
-0.019074423,
0.0043695597,
-0.019247344,
-0.0033004472,
0.007236044,
0.02410241,
0.0025821635,
-0.0055001914,
-0.0009336026,
0.0019520026,
-0.064007066,
-0.029157,
-0.026616404,
-0.0125899175,
-0.014405579,
0.0007066449,
0.011093494,
-0.017012684,
-0.020085342,
-0.000089006084,
-0.01920744,
-0.00021781289,
0.007109679,
0.03293464,
0.01612148,
-0.01955328,
0.013607486,
0.00015265608,
-0.008779024,
0.03532892,
-0.025884818,
0.03532892,
-0.007761455,
-0.019154234,
0.033945557,
-0.0049348753,
-0.0138735175,
-0.038388275,
0.000612287,
0.012323887,
0.044879433,
0.0053572,
-0.03806904,
-0.0013584209,
0.0022712399,
0.014671611,
0.016321003,
-0.010528178,
-0.010428416,
-0.0045690825,
0.024448251,
0.010215591,
-0.009557164,
0.0145785,
-0.030992614,
0.00072618155,
0.012643124,
0.0018422648,
0.012436951,
-0.00086543214,
0.012796092,
-0.011445984,
-0.012237427,
0.019925723,
-0.025499074,
0.012616521,
-0.018741885,
0.039505605,
0.02196086,
0.023849681,
0.020910038,
0.0102954,
0.028013065,
0.006225126,
0.0016909597,
-0.012869251,
0.02504682,
-0.01955328,
0.01612148,
0.019752802,
0.011718666,
0.013660693,
-0.014884436,
0.017185604,
0.03729755,
-0.01783738,
0.0070032664,
0.0029063888,
-0.049508374,
-0.04416115,
-0.01183838,
0.008346723,
-0.00553012,
-0.050918337,
-0.0043795356,
0.019619787,
0.0038707512,
0.00917807,
-0.013587534,
0.037350755,
0.0018406021,
0.04674165,
-0.0034118479,
0.013634089,
0.0075951857,
-0.031099027,
-0.008486389,
-0.0010026044,
0.0188749,
0.0010225567,
0.037084725,
0.020111945,
-0.013341456,
-0.0035348872,
-0.0030643449,
-0.006151967,
0.006278332,
0.0064878315,
-0.024820695,
0.00014455045,
-0.0039771637,
-0.0055400957,
-0.022612637,
0.01766446,
0.006338189,
-0.013700598,
0.018821694,
-0.0027351314,
0.006497808,
0.0038641004,
0.01191819,
0.02110956,
-0.039665226,
0.028970778,
0.027481005,
-0.019686295,
-0.02761402,
-0.0017242136,
0.0058859363,
0.0019353756,
0.024980312,
0.021362292,
-0.005899238,
-0.00570304,
-0.000122000165,
-0.0043429565,
0.0039671874,
-0.047725964,
0.0007665019,
0.020298166,
0.004426091,
-0.0071828375,
-0.003373606,
-0.026110945,
0.025153233,
-0.023051588,
-0.0049947323,
-0.0037709896,
0.013607486,
-0.0075153764,
0.0098631,
-0.034211587,
0.026988847,
-0.0019653041,
0.00004265849,
-0.020058738,
-0.036073808,
-0.0065310616,
0.010395162,
0.0048617166,
0.021043053,
0.00010189196,
0.002379315,
-0.0113661755,
0.0014606765,
-0.0065210853,
-0.016400812,
-0.007847915,
0.038441483,
-0.023104794,
0.008985198,
-0.0055633737,
0.013540979,
0.0071495837,
-0.013940025,
-0.007641741,
-0.012450252,
-0.034610637,
0.0063315383,
0.040862363,
0.0019237368,
-0.003953886,
-0.021229275,
-0.021495307,
0.001121487,
-0.024940409,
-0.013647391,
0.031232042,
-0.048843294,
-0.013713899,
0.01827633,
0.03242918,
0.02992849,
0.013634089,
-0.020165151,
-0.005566699,
0.044107944,
-0.014884436,
0.0061220387,
0.0050379625,
0.01277614,
-0.020364674,
-0.00031819803,
-0.0031956977,
-0.007641741,
-0.0019736176,
-0.020391278,
-0.0038574499,
-0.014073041,
-0.0061220387,
-0.013620788,
0.01534999,
-0.016281098,
0.0046089874,
0.013474471,
0.022266796,
-0.013793709,
-0.018076807,
0.029981695,
-0.028199287,
0.0066175214,
0.0133148525,
-0.0027035403,
0.0132084405,
-0.017691063,
-0.009896354,
0.013634089,
-0.012829346,
-0.0019486772,
-0.024554662,
0.00005860996,
-0.0096901795,
0.0010716062,
0.010760955,
0.0067771403,
-0.021029752,
0.012111062,
0.00019650963,
0.0011655485,
-0.003584768,
0.010508225,
0.0012495144,
0.044054735,
-0.017691063,
-0.004279774,
-0.01749154,
-0.018728584,
-0.04735352,
-0.009344339,
-0.02803967,
0.009856449,
0.018103411,
-0.009610371,
-0.012503458,
-0.015722433,
-0.022080574,
-0.023450634,
0.020138549,
-0.008087343,
0.0036113712,
0.0180236,
-0.00746217,
0.0034284748,
-0.031205438,
0.002106633,
-0.011339572,
0.0044892733,
0.021335687,
-0.00068710826,
0.028518526,
-0.005909214,
-0.03189712,
-0.021827845,
0.022359908,
0.009244578,
-0.0015271843,
0.019646391,
-0.0205775,
0.009503958,
0.0024025927,
-0.0075486302,
-0.006723934,
0.01620129,
0.018795092,
-0.02333092,
0.012277331,
-0.00574627,
0.013414614,
-0.009464053,
0.015722433,
-0.015363291,
0.023716666,
0.010155735,
-0.009444101,
-0.018648775,
0.011332922,
-0.0048218123,
-0.0005711353,
0.007788058,
-0.0000548689,
0.0205775,
0.011585651,
0.011539095,
-0.019513376,
0.0015662577,
-0.03147147,
-0.014285866,
0.0045059,
-0.009277832,
0.0050778673,
-0.018635472,
-0.020338072,
-0.03043395,
-0.017983697,
-0.0122573795,
-0.024674376,
-0.040356904,
0.018223125,
0.0059723966,
-0.01415285,
-0.010448368,
0.019220741,
-0.016653541,
-0.00883223,
0.004775257,
0.012782791,
-0.031418264,
0.029157,
-0.015576116,
0.002698552,
0.024541361,
0.009038404,
-0.013580884,
-0.010647891,
0.018156618,
0.20186433,
-0.0053239455,
0.018848298,
0.03181731,
0.0066674026,
0.0067172833,
0.04038351,
-0.009497307,
-0.0041733617,
0.02282546,
0.013261646,
-0.013740502,
-0.011997999,
0.0016585371,
0.051689826,
-0.0020434507,
-0.022000765,
-0.023623554,
-0.018728584,
0.016241193,
-0.005593302,
-0.024075808,
0.00420329,
0.0031192137,
0.0162944,
-0.0055700243,
-0.02734799,
0.008978547,
0.034105178,
0.0077415025,
-0.01594856,
0.0057562464,
0.0073557575,
-0.015230276,
0.022612637,
0.0013659031,
-0.025312852,
-0.0042764484,
-0.003627998,
-0.020377977,
0.0034484272,
-0.0028664842,
-0.015163768,
0.00074322417,
-0.018888202,
0.0066873548,
-0.0059823724,
-0.0069367588,
0.004020394,
-0.025339454,
-0.022612637,
0.02633707,
0.0015321724,
0.019672994,
-0.015682528,
-0.01311533,
0.021774638,
-0.016480621,
-0.009663577,
-0.00493155,
-0.011685412,
0.012131015,
-0.025153233,
0.0058693094,
-0.015762338,
0.036845297,
-0.013926724,
-0.012663077,
0.0049282247,
-0.019234043,
0.017292017,
-0.031870518,
-0.01844925,
0.0024508107,
0.010627939,
-0.0029030635,
0.03216315,
0.01397993,
0.015376593,
0.020364674,
0.011086843,
-0.003764339,
-0.016759954,
0.014245961,
-0.004389512,
-0.041633856,
0.03131185,
0.010674494,
0.0023876284,
-0.0046256143,
-0.009503958,
-0.010348607,
0.008685913,
0.0019320502,
0.015030753,
0.0032023485,
-0.0011464275,
-0.009670228,
-0.019393662,
-0.0011356199,
-0.014618404,
0.057835143,
0.011592302,
-0.010754304,
-0.0036945057,
0.0050712163,
-0.015083958,
-0.007960978,
0.02649669,
-0.026722817,
0.026470086,
-0.01731862,
0.003541538,
-0.00095937436,
-0.009796592,
0.027268179,
0.014418881,
-0.033945557,
0.022359908,
-0.00033253877,
-0.0014615079,
-0.004775257,
0.022173686,
0.0027617344,
-0.039931256,
-0.009996115,
-0.027068656,
-0.004219917,
-0.012663077,
-0.028279098,
-0.0022662517,
-0.015203672,
0.006803743,
0.0004165048,
-0.0024424973,
-0.0045491303,
0.012250728,
-0.017425032,
-0.031444866,
-0.011206557,
0.0048417645,
0.005101145,
0.004904947,
0.018076807,
0.007043171,
-0.023517143,
0.026975546,
0.0038474735,
-0.0079676295,
-0.029343221,
-0.021069657,
-0.009763339,
-0.0044792974,
-0.0022762278,
0.025073424,
-0.048391044,
-0.026549896,
-0.03139166,
-0.011898237,
0.021721432,
-0.015988464,
0.0021498632,
0.025938025,
-0.0061453166,
-0.007847915,
-0.00010651632,
-0.16855726,
0.022665843,
0.024062505,
-0.022000765,
0.023623554,
0.011020335,
-0.002367676,
-0.008552897,
0.0053904536,
0.0025755127,
0.009809894,
0.005453636,
-0.033067655,
-0.012343839,
-0.0047087492,
0.027826844,
-0.031524677,
0.036579266,
0.036818694,
0.01646732,
0.009045054,
-0.01690627,
0.009257879,
-0.0024624497,
0.006850299,
0.0028265796,
0.0024807393,
-0.018582266,
-0.023104794,
-0.0137272,
-0.010129131,
-0.0019154233,
0.014299167,
-0.012011301,
0.016666843,
-0.0068769017,
-0.024887202,
-0.00025439216,
-0.013713899,
0.0024607868,
0.0035781171,
0.018369442,
0.023862982,
-0.016653541,
-0.022226892,
0.03328048,
0.0067771403,
-0.012669727,
0.0030643449,
0.023144698,
-0.0014964244,
-0.0006496976,
0.026310468,
-0.0026486714,
0.024900503,
0.012503458,
-0.01415285,
0.012503458,
0.023650158,
0.012616521,
-0.020018835,
-0.022905272,
0.030327536,
0.0045724083,
-0.0074156146,
-0.041394427,
-0.0052707396,
0.020045437,
-0.014618404,
-0.0042232424,
0.005842706,
-0.02777364,
0.018236427,
-0.008433184,
0.028784556,
-0.0014581825,
0.0003524911,
0.007229393,
-0.0180236,
-0.025405962,
-0.035195902,
0.026031135,
-0.02325111,
-0.013334805,
-0.012616521,
0.0060222773,
-0.0025671993,
0.003800918,
-0.004751979,
0.0027085284,
0.008419882,
-0.022320002,
0.0090118,
-0.014378977,
0.00007928971,
0.036738884,
-0.012024602,
0.017637856,
-0.015283482,
-0.011638857,
0.023902887,
-0.00510447,
-0.025086725,
0.015536211,
0.008938642,
-0.012024602,
-0.0056930636,
-0.0022130455,
0.03910656,
0.014285866,
-0.010009417,
0.0038441482,
0.015057356,
0.016174685,
-0.015177069,
0.019101027,
0.010561432,
0.010561432,
0.005094494,
-0.013587534,
0.050306465,
-0.011186604,
0.029662458,
-0.00039967004,
0.020231659,
-0.0059058885,
-0.11481899,
-0.015815545,
0.0019170861,
0.03043395,
-0.003654601,
0.013095377,
-0.01604167,
0.019739501,
-0.021309085,
0.038973544,
-0.027401196,
-0.013660693,
-0.020617403,
-0.008379977,
0.005709691,
0.003340352,
-0.0018006974,
0.00012979405,
-0.025445867,
0.023743268,
-0.011698714,
0.0046455665,
0.005583326,
-0.024195522,
0.0025173186,
-0.0222934,
-0.04307042,
0.010561432,
0.0143124685,
0.008034137,
-0.01098043,
-0.011213208,
-0.008040788,
0.0006106243,
-0.032109942,
-0.01870198,
-0.0016419102,
-0.031072423,
0.031232042,
-0.021508608,
-0.0027816868,
-0.0034683794,
-0.0030410672,
0.011579,
-0.0062484033,
-0.023064889,
-0.0111467,
-0.0024325212,
-0.0018156617,
-0.029103793,
-0.023729967,
-0.02676272,
-0.021814544,
-0.009723433,
-0.01397993,
-0.009444101,
-0.018622171,
-0.00746217,
-0.023743268,
-0.0054935403,
-0.011805126,
-0.0016128131,
-0.014684912,
0.023636855,
0.010401812,
-0.0047652805,
-0.016879668,
-0.015150467,
-0.0032306141,
-0.028092876,
-0.010947176,
0.011465937,
-0.020510992,
-0.005430358,
-0.00728925,
0.0018938084,
-0.011193255,
-0.011605604,
0.029130397,
-0.0334401,
-0.017983697,
-0.012869251,
0.030673377,
-0.025685295,
0.029130397,
0.0127561875,
0.00806074,
-0.014631706,
0.019872516,
0.0012952385,
0.010913922,
0.029981695,
0.013953327,
-0.04323004,
-0.026576499,
0.0138735175,
0.0016851402,
-0.0009103249,
0.016347606,
0.012862599,
-0.019912422,
-0.012051205,
-0.057356287,
0.018755186,
-0.0011298005,
-0.017052589,
-0.007615138,
-0.004485948,
0.0090849595,
0.01955328,
-0.0052175336,
0.03213655,
-0.015403196,
0.022599336,
-0.0051410496,
-0.01646732,
-0.031870518,
-0.008559548,
0.028678143,
0.0060256026,
0.009763339,
0.034158383,
-0.0009834834,
0.0067804656,
-0.016360907,
-0.00458571,
-0.0123637915,
-0.0053039934,
-0.0058792857,
0.035541743,
-0.014285866,
-0.01988582,
0.01423266,
-0.00082178647,
-0.017983697,
0.010302051,
0.0073890113,
-0.031524677,
-0.007043171,
0.028837763,
0.02213378,
0.02169483,
-0.0010034357,
-0.025765104,
0.007196139,
0.0036778788,
-0.013348106,
0.011818428,
-0.032216355,
0.012370442,
-0.015882052,
-0.0034251495,
0.017105794,
-0.0072227423,
0.00977664,
-0.007408964,
-0.010455019,
-0.008752421,
-0.02161502,
-0.024634473,
-0.0018006974,
0.0015986802,
0.024049204,
0.034690443,
-0.0028781232,
0.015216975,
-0.0042398693,
-0.0045358287,
-0.020949943,
0.0015812218,
-0.0030809718,
-0.0205908,
-0.012150967,
0.010062623,
-0.0075353286,
0.017704364,
0.002030149,
-0.0047386773,
-0.005550072,
-0.0018189871,
0.008173803,
0.020178452,
0.016334305,
0.015203672,
0.008732468,
0.016547129,
0.030167917,
-0.0041866633,
-0.008912039,
0.032003533,
0.01028875,
0.013361408,
-0.007994232,
0.023703365,
0.026057739,
0.00866596,
-0.021575116,
0.029689062,
0.0056797625,
0.012855949,
-0.009198022,
0.01989912,
-0.00647453,
-0.012862599,
0.010794208,
-0.01895471,
-0.00832012,
0.019872516,
-0.02298508,
-0.04221912,
-0.013161885,
0.01612148,
0.007349107,
0.029396428,
0.00935099,
0.008273564,
-0.004914923,
-0.010528178,
-0.013068774,
-0.004229893,
-0.0010765942,
0.024980312,
0.003491657,
0.027853448,
0.007874518,
0.010900621,
0.01733192,
-0.0026636356,
0.03868091,
0.0031025868,
-0.0011372826,
-0.0030809718,
0.005024661,
-0.0013126968,
-0.02632377,
-0.011213208,
-0.0034318,
-0.017358525,
0.0109272245,
-0.0054403343,
-0.0041733617,
0.09912316,
0.01449869,
-0.024115711,
0.009124864,
-0.06108072,
0.010022718,
0.0022113828,
-0.00943745,
0.0047453283,
-0.04604997,
0.010667844,
-0.0017474913,
0.009996115,
-0.02537936,
-0.024448251,
-0.005473588,
0.0015246903,
0.00728925,
-0.02366346,
-0.013308202,
0.014645007,
-0.025259646,
0.0033702804,
0.038707513,
-0.019446867,
0.008020835,
0.023197904,
-0.009550514,
-0.015163768,
-0.017850682,
-0.005397104,
-0.005437009,
-0.022479622,
-0.027747035,
0.009929608,
-0.018941408,
0.02024496,
-0.020191755,
0.035062887,
0.017451635,
-0.0064712046,
0.01723881,
-0.010069274,
-0.010275448,
-0.01620129,
0.0003994622,
-0.013141932,
-0.022745652,
-0.0014906051
] |
Ractopamine hydrochloride (RAC) has consistently led to an advantage in carcass cutting yields of finishing pigs and remains a common feed additive in US finishing pig diets. Less is known about the effect of RAC on further processing characteristics. Some researchers have reported advantages in ultimate pH of the LM in pigs fed RAC. If a greater ultimate pH was also observed in hams, the increased pH could affect further processing characteristics and lead to better protein interaction and improved textural properties. The objective of this experiment was to determine if RAC-fed pigs yielded hams with a greater ultimate pH, and if so, whether or | [
0.0030605844,
-0.0011827286,
0.024768125,
-0.033852022,
-0.018451242,
0.021123769,
-0.023701815,
-0.027562132,
-0.052127793,
0.0056757475,
0.00037730054,
0.005996316,
-0.0095023215,
-0.0031027645,
-0.0011658566,
0.03188137,
0.03312315,
-0.0059423256,
-0.008409015,
0.0077813757,
0.0028446226,
-0.0036308588,
-0.021407219,
-0.005429416,
-0.008078324,
0.008530494,
0.03034264,
-0.015495263,
-0.020205932,
-0.0003406039,
-0.0065024765,
-0.008193053,
-0.003691598,
-0.0033001672,
-0.011405486,
0.0030133429,
0.0007495395,
-0.0004184261,
0.030288652,
-0.0029694755,
0.0143614635,
0.0051290942,
0.014874373,
-0.0031466319,
0.014860875,
0.00040830288,
0.0025611727,
-0.03018067,
-0.031449445,
0.027386663,
0.02445768,
0.00162815,
-0.0041201473,
-0.009333601,
0.011965637,
0.007039007,
0.009347099,
0.021758158,
0.003958176,
-0.01104105,
0.006107671,
0.01534679,
-0.048942357,
0.020448888,
-0.0005588857,
0.0010528141,
-0.000482118,
0.018559223,
0.019288093,
0.010548387,
0.022595009,
0.014968856,
-0.01239756,
-0.008449508,
0.015049842,
-0.0046398058,
-0.019031638,
-0.016224135,
0.02677927,
0.0035127546,
0.024282211,
-0.009488824,
-0.012654015,
0.041248716,
0.024822116,
0.014968856,
-0.020421892,
0.0022675996,
-0.0032681103,
0.0038636927,
0.008935422,
0.053639527,
0.018937156,
0.03782032,
-0.0015665671,
-0.0018913535,
-0.022675995,
0.033285122,
-0.030531608,
-0.017114976,
-0.00928636,
-0.0011076481,
-0.036605537,
-0.015522258,
-0.011979135,
-0.001562349,
-0.02480862,
-0.006046932,
0.009583307,
-0.0023823292,
-0.013490868,
0.038360227,
0.0033710296,
-0.02310792,
0.0150768375,
-0.012195096,
-0.0056183827,
0.0013117996,
-0.003440205,
-0.030018698,
0.008739706,
0.016426599,
0.019058634,
-0.0072212247,
0.014442449,
0.015589747,
-0.010075971,
-0.0037793326,
0.0018559223,
0.0034013994,
0.005655501,
-0.007025509,
0.011472974,
0.044488143,
-0.0038873134,
0.04880738,
-0.019868491,
-0.008368522,
-0.026981736,
-0.026819764,
0.005871463,
0.018586218,
-0.013126432,
-0.01313318,
-0.033420097,
0.015927186,
0.040330876,
0.012735001,
-0.0031803758,
0.00353975,
0.010143459,
-0.006897282,
0.014955359,
0.007862361,
0.003674726,
0.01268101,
0.013369389,
0.018113801,
-0.029019875,
-0.009434834,
0.007207727,
0.0007883451,
-0.011128784,
0.015805708,
0.035606712,
0.017006997,
0.046053868,
-0.010798093,
0.0046161846,
0.015589747,
0.012019627,
0.00809857,
0.010696861,
0.009826264,
0.00048464877,
0.019612037,
-0.014982354,
0.0020229553,
-0.011284007,
-0.0013624156,
-0.008341527,
0.013801313,
0.02633385,
0.0018356758,
0.011823912,
-0.01715547,
0.030234661,
-0.014388459,
-0.0042956164,
-0.017222958,
-0.006748808,
0.014914866,
-0.004231503,
-0.035525724,
-0.63708746,
-0.017182466,
-0.01970652,
-0.010291932,
0.018194787,
0.017695375,
0.02128574,
-0.011594452,
-0.00015342994,
0.007207727,
0.0013522924,
0.0064552347,
0.032826204,
-0.033986997,
-0.008118816,
-0.014874373,
0.027035724,
-0.028075041,
-0.007491177,
-0.006782552,
-0.026077395,
-0.0029256083,
-0.009974739,
-0.006387747,
0.023188904,
0.027278682,
0.025537489,
0.016939508,
-0.0014172497,
0.0063438797,
-0.023566838,
0.0025088694,
-0.0040796543,
-0.0054462883,
0.05204681,
-0.019220605,
-0.020286918,
0.0031955605,
0.004258498,
0.02502458,
0.013099437,
0.0026995232,
0.011884651,
0.005922079,
-0.020961799,
0.0045790663,
0.020435391,
0.027670113,
0.007821868,
-0.014658411,
-0.018410748,
-0.006890533,
-0.014509938,
0.030153675,
0.014388459,
-0.00003384949,
0.017897839,
-0.011135533,
-0.0036409819,
0.024268715,
0.007936599,
0.0009633924,
-0.031017521,
-0.023472354,
-0.03420296,
0.034688875,
-0.0010528141,
0.023310384,
-0.0030420253,
0.0035195034,
-0.0125865275,
0.023593834,
-0.0008347432,
-0.0074101915,
0.025861433,
0.005787103,
0.0031500063,
0.006748808,
-0.0031955605,
0.030882547,
0.0011641694,
-0.00353975,
-0.019652529,
0.010582131,
0.004025664,
-0.008773451,
-0.028803913,
0.014752895,
0.019922482,
-0.00007012433,
0.016359111,
0.0063843722,
-0.00047030757,
-0.00008388558,
-0.025726456,
0.01715547,
0.009212123,
-0.011803665,
-0.0024683767,
-0.012930716,
-0.041923597,
0.0030251532,
0.010042227,
0.017371433,
0.042382516,
0.007734134,
0.0086047305,
0.0052505727,
0.03498582,
-0.037631355,
0.004909758,
-0.0012004443,
0.00574661,
-0.013997028,
0.025389016,
-0.029667761,
0.024106743,
0.011263761,
0.001353136,
-0.03544474,
0.030261656,
0.014847378,
0.020178936,
0.009360597,
-0.00071495184,
0.020178936,
0.0005930515,
-0.01687202,
-0.013848554,
-0.0016121216,
0.025402514,
0.007572163,
0.03142245,
-0.025942419,
0.010494397,
0.033150144,
0.03374404,
0.002998158,
-0.00047832177,
-0.033096153,
-0.020570368,
0.01376082,
0.004025664,
0.0010055724,
-0.024336202,
-0.032988176,
-0.009590057,
0.008429261,
0.010244691,
0.00018053062,
0.01013671,
-0.01421299,
-0.016858522,
0.00569262,
0.0043394836,
-0.0053956723,
-0.0019065383,
-0.021447713,
-0.002588168,
-0.009245867,
-0.009488824,
0.030234661,
-0.013956536,
0.010163705,
-0.01998997,
-0.028614946,
-0.005729738,
0.016386107,
-0.022743484,
-0.017006997,
-0.008989412,
-0.014617918,
-0.0060435575,
0.0066442015,
-0.012883475,
0.024714135,
-0.009826264,
0.0026421584,
-0.020624358,
0.0053990465,
-0.01030543,
0.022743484,
-0.018073307,
-0.008800446,
0.0026961488,
0.013889047,
0.028129032,
0.015103833,
-0.014226488,
0.034499906,
-0.0021815521,
0.02842598,
-0.014253483,
0.014388459,
-0.019328587,
-0.026225869,
0.008145811,
-0.002513931,
0.009124389,
0.018707696,
-0.00088240666,
0.007808371,
0.017317442,
-0.02241954,
0.017519906,
0.01658857,
0.024700638,
-0.016399603,
0.017006997,
0.008530494,
-0.020975295,
-0.012053371,
-0.015589747,
-0.01149322,
-0.022190081,
0.036227603,
-0.039170083,
0.0063438797,
-0.008597981,
-0.01370008,
0.010204198,
0.008044579,
-0.000103393846,
-0.020624358,
-0.004693796,
-0.006475481,
0.006387747,
0.032286298,
-0.009542814,
-0.022972943,
-0.010865581,
0.014725899,
-0.00815256,
0.001549695,
0.02893889,
0.011176026,
0.001135487,
0.0056588757,
0.019922482,
0.022649,
0.008409015,
0.019787505,
0.020583864,
0.00027438122,
0.0042112563,
-0.002939106,
0.01823528,
0.018829174,
-0.016116153,
0.020030463,
-0.0017327565,
0.048672404,
-0.012782242,
0.010433657,
0.013754071,
0.0062224013,
0.0143614635,
0.011020804,
0.033393104,
0.016993498,
-0.01834326,
0.020070955,
-0.008112067,
-0.021704167,
-0.032232307,
-0.006823045,
0.0126472665,
-0.00501099,
-0.022797475,
-0.013200669,
-0.015184818,
-0.008672219,
0.008658721,
-0.02339137,
0.01800582,
0.0060840505,
0.015009349,
0.015184818,
-0.0021241873,
0.027049223,
-0.013173673,
-0.018707696,
0.033501085,
0.024930097,
0.0031010774,
0.012998205,
-0.022716489,
-0.000028603346,
-0.012471797,
0.005979444,
0.014442449,
0.012761996,
0.029100861,
0.00085119344,
-0.024889605,
-0.017236456,
0.017371433,
0.002230481,
0.045190018,
0.009374094,
-0.004167389,
-0.0054091695,
-0.0022642252,
-0.019517552,
0.036794502,
0.0056689987,
-0.013666336,
-0.025011083,
0.007673395,
-0.013801313,
0.00517971,
-0.008247044,
0.00068711303,
0.008260541,
0.0060773017,
0.019004643,
0.024673643,
-0.0029829731,
0.042328525,
-0.009644046,
0.0027754474,
-0.0020668225,
0.012613522,
-0.005820847,
0.028075041,
0.018073307,
0.008402267,
0.0118913995,
0.032259304,
0.010015232,
0.005318061,
-0.019908983,
0.0069580213,
-0.012127608,
0.0029458548,
-0.00088240666,
0.015751718,
-0.007862361,
0.020394899,
-0.004008792,
-0.011695685,
-0.034742866,
0.0101569565,
0.019490559,
0.03034264,
0.0037219676,
0.0043732277,
0.007774627,
0.02672528,
0.02893889,
0.026765773,
0.018073307,
0.026036901,
-0.038063277,
-0.000401765,
-0.026036901,
-0.019369079,
-0.004123522,
0.008827441,
-0.02270299,
-0.0053011887,
-0.022460034,
0.002304718,
0.03131447,
-0.005091976,
0.009448332,
0.0002562438,
-0.008199802,
0.010501145,
0.006387747,
0.002061761,
0.009104142,
-0.015508761,
-0.015927186,
0.025011083,
-0.010825088,
-0.0032883568,
0.022149589,
0.010528141,
0.0012181599,
-0.0022996564,
0.0043057394,
0.0069512725,
-0.017762862,
-0.010663116,
-0.0013421692,
0.023148412,
-0.010663116,
-0.028668936,
-0.028722927,
-0.029964708,
-0.03204334,
-0.02474113,
0.0045689433,
-0.0018154294,
-0.034283943,
-0.0094415825,
0.012525788,
0.014968856,
-0.021623181,
0.01563024,
-0.0021073152,
-0.008166058,
-0.0085844835,
0.002864869,
-0.011243515,
-0.009644046,
-0.03601164,
-0.015090335,
0.01155396,
-0.00091024546,
-0.026320351,
-0.035039812,
-0.006505851,
0.005068355,
-0.006286515,
0.01891016,
-0.011182775,
0.0019065383,
-0.011520215,
-0.0024464428,
0.007882608,
0.007875859,
-0.010919572,
-0.015373785,
-0.008402267,
-0.016683053,
-0.0030049067,
0.016467093,
-0.01653458,
-0.005385549,
-0.009556312,
0.0002570874,
-0.0061312923,
0.020489382,
-0.01568423,
-0.020799827,
0.02401226,
0.012869977,
0.012222092,
-0.015022847,
0.005000867,
-0.00038573655,
-0.019517552,
-0.016858522,
-0.028803913,
0.028318,
0.0029627269,
-0.04545997,
0.020961799,
0.01353136,
-0.0071267416,
-0.03895412,
-0.007943347,
-0.006249396,
0.035147794,
-0.008530494,
-0.02576695,
-0.021137267,
-0.030396631,
-0.020394899,
0.015927186,
-0.0118104145,
-0.022433039,
-0.017209461,
0.0030791436,
-0.02479512,
0.0067758034,
0.011783419,
-0.046755742,
-0.0007411035,
0.002589855,
0.0014855814,
0.0018474862,
-0.0038029533,
-0.0022895331,
-0.010264937,
0.008274038,
-0.013578602,
-0.035579715,
0.02480862,
-0.008274038,
0.018694198,
0.027670113,
0.051668875,
-0.002270974,
-0.017276948,
0.02457916,
0.0010620937,
0.0031618166,
-0.025847934,
0.02785908,
-0.010035478,
0.02654981,
0.011304254,
0.0049806205,
0.004035787,
-0.0064012446,
0.014024023,
0.016008172,
0.016170144,
-0.027130209,
0.002362083,
-0.014307473,
-0.015927186,
0.009549564,
0.008321281,
-0.0010199136,
-0.034796856,
-0.012977958,
0.010170454,
0.0015665671,
-0.0047984025,
-0.013396384,
0.0045318245,
-0.03611962,
0.004903009,
0.0127687445,
0.00648223,
0.0075451676,
-0.008861185,
-0.01970652,
0.011088292,
0.011499969,
0.012282831,
0.011445979,
0.018761687,
-0.04840245,
-0.0109330695,
-0.0033339113,
-0.0075789117,
-0.007443935,
-0.015697727,
-0.03306916,
-0.0277511,
-0.010251439,
0.008685716,
-0.03369005,
0.019854993,
0.019045137,
-0.024565661,
0.012633769,
-0.013072441,
0.0006149851,
0.039440036,
-0.0019335335,
0.0051324684,
-0.016345613,
0.0029053618,
0.032097332,
-0.011702433,
-0.02333738,
-0.0085642375,
-0.008773451,
0.005375426,
0.02780509,
0.014766392,
0.0026303479,
-0.014577425,
-0.0037219676,
0.016791034,
-0.009590057,
-0.03250226,
0.0016939508,
0.0073292055,
0.016737044,
-0.007801622,
-0.014941861,
-0.0055475202,
0.0010671553,
-0.027994055,
-0.0042450004,
0.0017310693,
-0.008314531,
-0.026995232,
0.029181845,
-0.0002461206,
0.02367482,
0.006289889,
-0.015859699,
-0.023485852,
-0.004535199,
-0.021690669,
0.022217076,
-0.018113801,
0.009394341,
-0.014469445,
0.022891957,
-0.004683673,
-0.018599715,
0.020030463,
-0.0041943844,
-0.018127298,
0.034499906,
0.0030757694,
-0.014428952,
0.017357934,
0.017222958,
0.00059853494,
-0.017992323,
-0.0015893443,
-0.018815678,
-0.010804842,
-0.008159309,
0.022662498,
0.0085034985,
-0.04921231,
-0.0061920313,
0.005017739,
-0.0085237445,
-0.030288652,
-0.00566225,
-0.0024515046,
-0.012201845,
-0.03647056,
0.013862052,
0.0034621386,
0.015643736,
0.005284317,
-0.0020769457,
-0.012869977,
0.0072684665,
-0.0277511,
0.018424246,
-0.007855613,
-0.015508761,
-0.0015505387,
0.0041640145,
-0.033312116,
-0.020367904,
0.0023857036,
-0.0026303479,
-0.046512786,
-0.01573822,
-0.006138041,
0.010696861,
0.02305393,
-0.00026446892,
0.013092687,
0.012552783,
0.022851463,
0.022379048,
0.005739861,
0.0077813757,
-0.022271067,
0.0011337998,
0.016129652,
-0.018923657,
0.008490001,
-0.023377871,
-0.010399913,
0.007072751,
-0.0050211134,
-0.0033710296,
-0.015454771,
0.036227603,
-0.011688936,
0.00068711303,
-0.01426698,
0.0036713516,
-0.018316265,
0.0143209705,
0.0035633708,
-0.018451242,
-0.0078286175,
-0.0015750031,
-0.0049806205,
0.005334933,
-0.019301591,
0.014874373,
0.02530803,
0.0009161507,
-0.019598538,
-0.013943038,
-0.014185995,
0.024876107,
0.00713349,
-0.012377314,
-0.012188347,
-0.0025847936,
-0.037280414,
-0.010831837,
-0.009934246,
-0.0011827286,
0.0019234103,
-0.021150764,
0.013848554,
-0.0042011333,
-0.015157823,
-0.006488979,
0.0033001672,
-0.014037521,
-0.002939106,
-0.0020988793,
0.023904279,
-0.0004057721,
-0.039278064,
-0.004342858,
0.036848493,
-0.004761284,
0.006171785,
0.01506334,
0.004778156,
0.016075661,
-0.0019571544,
0.015792212,
0.014968856,
0.0009878568,
0.015090335,
-0.013173673,
-0.015900193,
0.044056218,
-0.016089158,
-0.011162529,
0.0006107671,
0.0066846944,
0.00843601,
0.0046634264,
0.0056251315,
-0.032313295,
0.009495573,
-0.031611416,
0.008618228,
0.030639589,
-0.02950579,
0.006289889,
0.010885827,
-0.008172806,
-0.019315088,
0.016507585,
0.01823528,
0.0027535136,
0.011702433,
0.0013489181,
0.012262585,
-0.0019183487,
0.033609066,
-0.003958176,
-0.017141972,
-0.015832704,
-0.0013016764,
-0.012276082,
0.025523992,
-0.011601201,
0.01506334,
-0.020813324,
-0.0073696985,
-0.018802179,
0.016926011,
-0.01862671,
0.008753204,
-0.013254659,
-0.004676924,
-0.009576559,
-0.030720575,
0.017870843,
0.015873197,
-0.035984647,
-0.033717044,
0.017290447,
0.18723893,
0.016642561,
0.01177667,
0.0086249765,
0.0101164635,
-0.011695685,
0.004508204,
0.002188301,
-0.006748808,
0.0070592533,
0.03822525,
0.02275698,
-0.043246362,
0.00018010882,
0.0045655686,
0.00042158962,
-0.024565661,
-0.0024919973,
-0.004575692,
-0.010345923,
0.025537489,
0.004960374,
-0.0040965267,
0.0074371863,
0.028156027,
-0.0134638725,
0.0074169403,
-0.010656368,
0.01313993,
0.024754629,
-0.020529874,
0.0008469754,
-0.01341663,
0.019962974,
0.00036612284,
0.007821868,
-0.015940685,
-0.023283388,
0.006991765,
0.017789857,
-0.011742926,
0.020583864,
0.027643118,
-0.01426698,
-0.019315088,
0.002004396,
0.011243515,
-0.010845334,
-0.011230017,
-0.006998514,
-0.032880194,
-0.004126896,
0.0379283,
0.0092796115,
0.006138041,
-0.00029715846,
0.008085072,
-0.007356201,
-0.021096773,
0.025092069,
-0.012890223,
0.016453594,
0.0030268405,
0.014712402,
-0.03611962,
-0.012316574,
-0.037847314,
0.018505232,
0.0066745714,
-0.0078488635,
0.02395827,
-0.01228958,
-0.016885517,
-0.022568014,
-0.012525788,
-0.02837199,
0.004859142,
0.028129032,
0.019774009,
0.037631355,
-0.0043462324,
0.0037320908,
-0.00517971,
-0.004325986,
-0.033150144,
-0.035687696,
0.028264008,
0.024133738,
-0.013862052,
-0.0065767136,
0.006519349,
-0.004349607,
-0.02598291,
0.00023325568,
-0.004224754,
-0.03296118,
-0.018356757,
0.020219428,
-0.0056689987,
0.032097332,
-0.014901368,
0.057715807,
-0.016629063,
0.0060334345,
-0.01681803,
-0.0067926752,
-0.006758931,
0.031044517,
-0.00078623614,
-0.015549254,
-0.0011413922,
-0.030666584,
0.004575692,
-0.015576249,
0.015090335,
0.014105009,
0.0110950405,
-0.024214724,
0.024957092,
-0.006019937,
-0.001528605,
-0.017425422,
-0.010102966,
0.010818339,
-0.012822735,
-0.019517552,
-0.021434214,
-0.00676568,
0.005695994,
-0.02610439,
0.0073292055,
-0.00338284,
-0.007039007,
-0.016966503,
-0.013517862,
-0.0027889449,
-0.00809857,
-0.010602377,
0.018127298,
0.017195962,
0.0004825398,
0.014685406,
0.020880813,
-0.0077881245,
0.007025509,
-0.011513467,
0.0134638725,
0.008058077,
-0.028344994,
-0.013747322,
0.004008792,
-0.016980002,
-0.0066104573,
-0.011628197,
-0.008361774,
-0.0076801437,
-0.022945948,
-0.0232159,
0.00945508,
0.018329762,
-0.035633706,
-0.012370565,
0.018167792,
0.006971519,
-0.0029677884,
-0.0016306808,
-0.17060986,
0.025065074,
0.024889605,
-0.021123769,
0.006252771,
0.0055913874,
0.037118446,
-0.0007284495,
-0.026347347,
0.000065115455,
0.030531608,
0.0022169834,
-0.009563061,
-0.04492007,
0.0076936414,
0.010426909,
-0.015900193,
-0.0030791436,
0.0003486181,
-0.006121169,
-0.015603244,
-0.01166194,
0.04967123,
-0.008037831,
0.005638629,
0.017762862,
-0.017938333,
-0.007315708,
-0.0035060057,
-0.018329762,
-0.0005719615,
-0.0062156525,
0.01947706,
-0.012579778,
0.007902854,
-0.0019504055,
-0.022837967,
0.013565104,
-0.027413659,
0.00092543033,
0.024849111,
0.020057458,
-0.017978825,
-0.009070398,
-0.0038974367,
0.043111388,
0.0054395394,
-0.004633057,
0.008294285,
-0.016156647,
0.014955359,
-0.0027417033,
0.03147644,
0.017060988,
-0.022068603,
0.009536066,
-0.0016399603,
-0.0014400269,
-0.015157823,
-0.023850288,
-0.008469754,
-0.00071579544,
0.030990526,
0.0070525045,
-0.003934555,
-0.026239365,
-0.007214476,
-0.0050582318,
-0.018356757,
0.0019352207,
-0.014159,
-0.00334066,
-0.0101974495,
-0.009758776,
0.00047326018,
0.015589747,
0.0020533248,
0.013889047,
-0.0054395394,
0.013301901,
0.0038366974,
-0.00045723174,
-0.03528277,
-0.034742866,
-0.014415454,
-0.015805708,
0.00035367973,
0.028237013,
0.018437743,
0.0023688315,
0.040897775,
-0.0036781004,
0.01506334,
-0.03590366,
-0.004994118,
0.022851463,
-0.018680701,
0.0024025757,
-0.0049333787,
-0.053207602,
0.019841496,
-0.019504055,
-0.023904279,
0.004393474,
0.030504612,
0.007106495,
-0.016575072,
-0.0042888676,
0.040384866,
-0.02146121,
0.0025375518,
0.014523435,
0.016642561,
0.031152498,
-0.021609684,
0.029991703,
-0.0044272183,
-0.011918395,
0.0126675125,
-0.018019317,
0.047457617,
0.0037860814,
-0.012782242,
0.017816853,
-0.008442759,
-0.03957501,
-0.13616395,
-0.027535137,
0.011884651,
-0.002545988,
-0.015832704,
0.0072212247,
0.021312736,
0.014725899,
-0.016656058,
0.024592657,
-0.001035942,
-0.011425732,
0.0051189708,
0.011857656,
0.028102037,
0.019490559,
-0.008476503,
-0.02451167,
-0.01506334,
0.024903102,
0.0025662342,
0.0027417033,
-0.005176336,
-0.028156027,
0.0058680885,
0.0016964816,
0.004660052,
0.008017584,
0.010183952,
0.007173983,
0.022379048,
-0.0110140545,
0.03652455,
-0.021758158,
0.0017411925,
-0.017587394,
-0.0067623057,
0.0032225559,
0.02729218,
-0.010919572,
0.0062089036,
-0.0049907435,
0.0073696985,
-0.003944678,
0.031341463,
-0.031503435,
0.007943347,
0.027778095,
-0.0018525479,
-0.007673395,
0.00030791436,
-0.023472354,
-0.031341463,
0.008361774,
0.028857904,
-0.034229953,
0.020151941,
0.02858795,
-0.02598291,
-0.022284564,
-0.023715312,
0.00809857,
-0.020205932,
0.0044305925,
0.011675438,
-0.020030463,
0.004454213,
-0.024646647,
0.035714693,
-0.030828556,
-0.0023857036,
0.02367482,
-0.012363817,
0.00027121772,
-0.021137267,
0.015805708,
-0.05158789,
-0.015265804,
0.0078488635,
0.009967989,
-0.017479412,
-0.017600892,
0.009488824,
-0.009158133,
-0.0085439915,
-0.0047410377,
0.013889047,
-0.00009274339,
-0.0039885454,
-0.022311559,
-0.010170454,
0.029451799,
0.019868491,
-0.004501455,
-0.034526903,
0.018248778,
-0.0151983155,
0.006121169,
0.015562751,
-0.0054496625,
-0.04994118,
-0.015225311,
-0.045432977,
0.012053371,
-0.0005753359,
-0.020853817,
-0.0016610504,
-0.029235836,
0.020219428,
-0.002680964,
0.01392954,
-0.004039162,
-0.017708873,
0.024781624,
-0.021650176,
-0.015670732,
-0.019045137,
-0.006053681,
0.029343817,
0.02424172,
0.010568634,
0.0066273296,
-0.005550895,
-0.009826264,
-0.01324791,
-0.0016087472,
-0.008145811,
-0.00031318687,
-0.020529874,
0.008874683,
0.0039615505,
0.014388459,
0.01353136,
-0.03487784,
-0.016116153,
0.010966813,
-0.015373785,
-0.0040189154,
-0.02904687,
0.015157823,
-0.0021258746,
0.004231503,
-0.019787505,
-0.016696552,
0.007025509,
-0.032178316,
0.015387283,
0.0017766238,
-0.031179493,
0.018397251,
-0.006998514,
-0.0011886338,
0.027724104,
0.020570368,
0.016845025,
-0.026144883,
-0.0025324903,
-0.0063337563,
-0.0075991577,
0.01676404,
-0.0066846944,
0.005068355,
0.020529874,
0.004143768,
0.0203814,
-0.014644913,
0.010892577,
-0.0042078816,
-0.0075114234,
-0.0094618285,
0.025523992,
-0.013848554,
-0.03255625,
0.009556312,
0.04008792,
0.0012215342,
0.014631416,
-0.010332425,
0.008928673,
0.024025757,
0.005648752,
-0.008226797,
0.012026376,
0.0057094917,
-0.019544547,
0.01772237,
0.022433039,
-0.014793388,
-0.013153427,
-0.011533713,
0.01262702,
-0.005601511,
-0.025267538,
0.024849111,
0.0023367747,
-0.0059456998,
-0.021420717,
0.007342703,
0.0075451676,
-0.017560398,
0.012438053,
0.026752274,
-0.006839917,
0.003330537,
-0.0035228778,
-0.036254596,
-0.020570368,
0.007909603,
-0.023202403,
-0.033474088,
0.0008149186,
0.02241954,
0.019841496,
-0.03946703,
0.019301591,
0.009994985,
0.0071604853,
0.022163086,
-0.018086806,
-0.016575072,
-0.0005778667,
0.041248716,
0.011216519,
0.00044373414,
0.016264627,
0.017627887,
-0.012910469,
-0.009617051,
0.015279301,
-0.035012815,
0.012869977,
-0.0075586652,
0.009239119,
-0.040276885,
-0.052748684,
-0.019935979,
-0.0065429695,
0.0074709305,
0.022541018,
0.03323113,
-0.02853396,
0.0968049,
-0.0005706961,
-0.003266423,
0.0040155407,
0.008429261,
0.022190081,
-0.0020516377,
0.008280788,
-0.009731782,
-0.019571543,
-0.0045149527,
-0.019369079,
0.05390948,
-0.036254596,
-0.012694508,
0.012532537,
0.011688936,
0.011337997,
-0.0002511822,
-0.0070525045,
0.02780509,
0.0053045633,
0.0025594854,
0.029802736,
-0.023283388,
-0.0037759582,
0.015481765,
-0.008557488,
0.013288403,
-0.045378987,
-0.0043124883,
0.023121417,
-0.04597288,
0.0015395718,
-0.010420159,
0.000028761522,
-0.00014689202,
0.011877902,
0.025577983,
0.0009001223,
-0.02304043,
0.0055677667,
-0.0059929416,
-0.015859699,
-0.0020364528,
-0.007592409,
0.007214476,
0.009232369,
0.003941304
] |
Cystic Fibrosis (CF) is an inherited pleiotropic disease that results from abnormalities in the gene codes of a chloride channel. The lungs of CF patients are chronically infected by several pathogens but bacteraemia have rarely been reported in this pathology. Besides that, circulating monocytes in CF patients exhibit a patent Endotoxin Tolerance (ET) state since they show a significant reduction of the inflammatory response to bacterial stimulus. Despite a previous description of this phenomenon, the direct cause of ET in CF patients remains unknown. In this study we have researched the possible role of microbial/endotoxin translocation from a localized infection to | [
-0.02838518,
-0.010552282,
-0.021354713,
-0.022802936,
-0.020643767,
0.014534896,
-0.03330914,
-0.009887416,
-0.03868073,
0.013113004,
0.0071752886,
-0.002302346,
0.011157903,
0.018971726,
0.005868596,
0.0069843866,
0.027884884,
-0.014771879,
-0.02002498,
-0.016101612,
-0.03315115,
0.042367116,
0.0025146424,
-0.02023563,
0.00088292256,
0.012961599,
0.021525865,
-0.046922438,
-0.009031648,
-0.02069643,
-0.0075768414,
0.014824541,
-0.030439023,
0.018431934,
-0.01026922,
-0.012941851,
0.016457085,
0.00081750564,
0.042762086,
-0.019419359,
0.02485678,
0.012434972,
-0.009867667,
0.030518016,
-0.008103468,
-0.006237235,
0.0020900497,
-0.019261371,
0.0039299517,
-0.021736516,
0.026449826,
0.008742003,
0.0010639505,
-0.02093341,
-0.014021436,
-0.009288378,
-0.014179423,
0.010881424,
0.0070173005,
-0.024172164,
-0.01953785,
-0.004186682,
-0.026752636,
-0.005072073,
-0.016944213,
0.025080595,
0.009525361,
0.024619797,
-0.004035277,
0.032229554,
0.02427749,
0.03333547,
0.0069317236,
0.014785044,
0.022723941,
0.00039085574,
-0.016154274,
0.009736011,
-0.03001772,
0.011803021,
0.026897458,
-0.01110524,
-0.023276899,
0.024514472,
0.026778966,
-0.014719216,
0.001134716,
0.005055616,
0.0029639208,
-0.009011899,
0.032018904,
0.00887366,
0.013494809,
0.019274537,
-0.0046935603,
0.015416997,
-0.008333867,
0.034283396,
0.014732381,
-0.037153512,
-0.017734153,
0.018234449,
-0.015272174,
-0.018734744,
-0.03357245,
0.020038145,
0.0048054685,
-0.008149548,
0.016812557,
-0.020735925,
-0.008551101,
0.039339013,
0.006530171,
-0.03170293,
0.046053503,
0.006263566,
0.0046540634,
-0.007524179,
-0.0009726137,
-0.006049624,
0.013099839,
0.013626466,
0.0021575238,
-0.009742593,
0.009762342,
-0.009011899,
-0.036021266,
-0.014034601,
-0.023606041,
-0.0064380113,
0.004644189,
0.0074715163,
0.023922017,
-0.0008022828,
-0.023685034,
0.010203392,
-0.039786648,
0.0019715587,
-0.019972317,
-0.008985568,
0.0006274263,
0.021315215,
-0.013955607,
0.0015839944,
0.01303401,
0.01805013,
0.017036373,
0.012066334,
0.011934677,
-0.0105062025,
0.0087156715,
-0.007675584,
0.00071218034,
-0.010598362,
0.0018678791,
0.014179423,
-0.020828085,
0.017944803,
-0.015232677,
-0.036969192,
-0.0263445,
-0.008742003,
0.0087156715,
0.0066980333,
0.033440795,
0.017905308,
0.019643176,
0.016417587,
0.008169296,
0.016628237,
-0.00917647,
0.0061779893,
-0.00031618171,
0.023461219,
0.022579119,
0.013020845,
-0.021776013,
0.0028372013,
0.0058389734,
-0.026199678,
-0.038259428,
0.042762086,
0.029701745,
-0.017720988,
-0.009150139,
-0.018221283,
0.030281035,
-0.0025755337,
0.013053759,
-0.021446873,
-0.022131486,
0.009367372,
0.0056678196,
-0.032413874,
-0.6311094,
-0.025304412,
0.014521731,
-0.001253207,
-0.0097096795,
0.014455902,
-0.009808422,
-0.019669507,
-0.035231326,
0.011671364,
-0.008682758,
0.02527808,
0.0052004387,
-0.013073508,
0.008360199,
-0.016404422,
-0.017602498,
-0.012816777,
0.012797029,
-0.0034263649,
0.0012795383,
-0.0033325595,
-0.012349396,
0.026186513,
-0.0133368205,
0.024356484,
0.033203814,
-0.008268039,
-0.002302346,
0.018563591,
-0.009308127,
0.01321833,
0.017852645,
-0.0059739216,
0.052030716,
0.00052744953,
-0.01089459,
0.016838888,
0.023645539,
0.0013733436,
0.005937716,
0.0004735526,
0.038549073,
-0.004374293,
-0.002269432,
0.052689,
0.008136382,
0.011934677,
0.006230652,
-0.004835091,
-0.0033292682,
0.0022990545,
-0.014785044,
-0.010078318,
0.0215127,
-0.015022026,
0.014785044,
-0.023263734,
0.019972317,
0.017602498,
-0.003561313,
0.037680138,
0.0018349648,
-0.017760485,
0.0005636551,
-0.021749683,
-0.01726019,
-0.018063296,
0.014982529,
-0.011585787,
0.02464613,
0.034862686,
-0.00059903786,
0.01990649,
0.0137186255,
0.051846396,
0.0068263984,
0.0010483162,
-0.018905899,
0.022236811,
0.0009002025,
-0.0046310234,
-0.030518016,
0.011348805,
0.0289908,
0.016180605,
-0.008603764,
0.020261962,
-0.027595239,
0.00045956406,
-0.0075834244,
0.018431934,
-0.023290066,
-0.027516244,
-0.018366106,
0.00824829,
-0.014732381,
-0.017405013,
-0.001021162,
-0.003719301,
-0.027068611,
-0.023829857,
-0.010084901,
-0.010657608,
0.019827494,
0.0013132753,
-0.012415224,
-0.009117224,
0.03230855,
-0.031860914,
0.0010738247,
-0.0029474637,
0.004920668,
-0.036021266,
0.008630095,
-0.01865575,
0.014864039,
0.019129714,
0.005845556,
-0.023513881,
0.00029643322,
-0.0069843866,
-0.005305764,
-0.010328466,
-0.017115368,
0.011375137,
0.007675584,
-0.028490504,
0.004733057,
-0.006349143,
-0.021367878,
-0.014482234,
0.04047126,
-0.011408051,
0.028095534,
0.013409232,
0.03986564,
0.009538526,
-0.009953245,
-0.031044643,
-0.021196725,
-0.0069317236,
0.017023208,
0.012072917,
-0.0015782344,
0.00066445477,
-0.009795256,
-0.017444508,
-0.019735334,
-0.004239345,
0.019287702,
0.012283567,
0.009736011,
0.026331335,
0.03478369,
0.00044063843,
0.022368468,
-0.026489323,
-0.017615663,
-0.017220693,
0.01719436,
-0.0008714026,
0.008017891,
0.0038674148,
-0.0046771034,
-0.00038201007,
0.0016226685,
-0.0022760148,
0.004068191,
-0.019643176,
0.00046408977,
-0.013494809,
0.0015617773,
0.019077051,
-0.004792303,
0.004690269,
-0.007557093,
-0.02436965,
-0.006237235,
-0.008926323,
0.0018036964,
-0.010631276,
-0.005434129,
0.012836525,
0.005960756,
0.007820406,
-0.00004530841,
-0.009275213,
0.009025065,
0.043552026,
-0.018550426,
0.0051938556,
-0.020011814,
0.030439023,
0.024619797,
-0.012711451,
0.011763523,
0.021736516,
0.0137186255,
0.028964467,
-0.01470605,
-0.023658704,
0.02169702,
-0.038233098,
0.030465353,
-0.048844624,
-0.019261371,
-0.008320701,
0.046132497,
-0.0025245168,
-0.014692885,
0.028174527,
0.007754578,
0.004199848,
-0.014679719,
0.025291247,
0.010670774,
-0.018984891,
-0.00027586188,
-0.00750443,
-0.022710776,
0.0026676934,
0.023553379,
0.023658704,
-0.0068724784,
0.013837116,
0.0031663429,
-0.0021097981,
-0.0043808757,
-0.013481643,
0.0059179673,
0.00010769104,
0.019406194,
0.0006809119,
-0.006642079,
0.020986073,
0.008511604,
0.009505612,
0.025870536,
0.002990252,
0.0028289726,
0.021012405,
0.0215127,
0.002901384,
-0.015561819,
-0.0025195796,
0.018339774,
0.008682758,
0.0027779557,
-0.004943708,
-0.0071423743,
-0.0048778797,
-0.013968773,
-0.024843615,
-0.024909442,
-0.003042915,
-0.013784453,
-0.0017345767,
0.04318339,
-0.0047198916,
0.017628828,
-0.02820086,
0.00803764,
-0.01637809,
0.01728652,
0.010354797,
-0.014218921,
-0.025541395,
-0.012902354,
-0.003860832,
-0.04078724,
-0.008880243,
0.016549245,
-0.0043973327,
0.02130205,
0.00799156,
0.004476327,
0.0023698201,
0.0033424338,
0.00480876,
0.0011972529,
-0.016180605,
0.016206937,
0.025317578,
-0.012876023,
-0.010203392,
-0.01923504,
0.01238231,
-0.021802345,
0.03986564,
-0.009196218,
0.016917882,
0.02041995,
0.002871761,
-0.0026841504,
0.012922103,
-0.003138366,
-0.016575575,
0.03847008,
0.024145834,
-0.0145612275,
0.01101308,
-0.0016671026,
-0.0022957632,
0.033862095,
0.027647901,
-0.014982529,
0.0051444843,
-0.005118153,
-0.037416827,
0.00673753,
-0.0103153,
-0.020472612,
-0.018392436,
-0.0034296564,
0.0077282465,
-0.011658198,
-0.013771288,
0.039181024,
-0.04060292,
-0.008149548,
-0.038022447,
-0.011131572,
0.0035547302,
0.022947758,
0.018431934,
-0.015811967,
0.0081298,
-0.0034263649,
0.014060932,
0.021130895,
-0.019103384,
0.01586463,
-0.0049766223,
-0.005825808,
-0.02455397,
0.02555456,
0.009670182,
0.003352308,
0.026002193,
-0.0040056542,
-0.010809013,
-0.024632962,
0.016457085,
0.013758122,
-0.018892732,
0.029675413,
0.015219511,
0.019300869,
-0.014864039,
-0.0054308376,
0.011612118,
0.004318339,
-0.0075636758,
-0.020090807,
0.0070436317,
-0.0010277448,
-0.006089121,
-0.001117436,
0.0004645012,
-0.0110262465,
-0.0037028438,
0.0010573677,
0.005572369,
0.01540383,
0.014982529,
0.02436965,
-0.00434467,
0.013284158,
-0.0063787657,
-0.006734239,
0.0065927077,
0.018550426,
-0.026226008,
0.04502658,
-0.02859583,
-0.0076690014,
-0.020169802,
0.016799392,
-0.023500716,
0.011513376,
-0.008847328,
-0.0037917122,
-0.003273314,
-0.0077084983,
-0.032835174,
0.0051379018,
0.0055624945,
-0.013251244,
0.0051905643,
-0.0012556755,
-0.012645624,
-0.016062114,
-0.019050721,
-0.0016967254,
-0.038075108,
-0.008623512,
0.007952063,
0.010394294,
0.0109340865,
0.028253522,
0.0070699635,
0.0044170814,
0.024014177,
0.002527808,
0.010986749,
-0.0047001434,
-0.030912986,
0.0053814664,
0.0017230567,
0.03178192,
-0.010743184,
-0.03673221,
0.02357971,
0.00059903786,
-0.015825132,
0.01317225,
0.018853236,
-0.0056250314,
0.013942442,
0.01568031,
0.016220102,
-0.016825723,
-0.018458266,
0.004690269,
-0.0325192,
-0.0098939985,
-0.008965819,
-0.005052325,
-0.022526456,
0.00059944927,
-0.013238078,
-0.011967592,
-0.0017279938,
0.005335387,
-0.007313528,
-0.015140518,
0.0035646043,
0.02357971,
0.02978074,
-0.014390075,
0.0051379018,
0.018998059,
-0.012441555,
0.009202802,
-0.016799392,
0.009545108,
-0.001241687,
-0.013889779,
-0.002861887,
0.018431934,
-0.02999139,
-0.037996117,
-0.0027582073,
-0.02178918,
0.014060932,
0.009907165,
-0.02683163,
-0.0426041,
0.0057698535,
-0.0044565783,
0.024935775,
-0.019827494,
-0.023184739,
-0.025752045,
-0.0059475903,
-0.004282133,
-0.029096125,
0.024659295,
-0.0355473,
0.0032667313,
0.0075768414,
-0.006576251,
0.014416406,
-0.01607528,
-0.0019485188,
-0.014350577,
-0.0026051565,
-0.013014262,
-0.04184049,
-0.011256645,
-0.019274537,
0.037996117,
0.029359438,
0.0069119753,
-0.016931048,
0.033467125,
0.018524094,
0.014732381,
0.0038180435,
-0.010051987,
-0.005124736,
-0.007984977,
0.0008969111,
0.012586378,
0.018892732,
0.021749683,
-0.043736346,
0.023816692,
0.014376909,
-0.010697105,
0.005440712,
-0.0065202964,
-0.023566544,
-0.016996877,
0.02841151,
-0.00157988,
0.018418768,
-0.04144552,
-0.014745547,
0.01080243,
-0.010295552,
-0.0033737023,
-0.011157903,
0.012698286,
-0.035626296,
0.024330152,
-0.037996117,
0.009834753,
-0.0038674148,
-0.00676057,
-0.0075834244,
-0.018418768,
0.0012548526,
0.0065927077,
-0.0013009325,
-0.014047767,
-0.0016629883,
0.0071094604,
-0.009847919,
0.0013988521,
-0.0223948,
-0.015719807,
-0.010855093,
-0.02142054,
-0.0017460966,
0.010216557,
-0.046448473,
0.013810785,
0.0016917882,
-0.004706726,
0.03038636,
-0.013099839,
-0.015601316,
0.020841252,
0.002924424,
-0.0009471052,
-0.018313443,
0.026291838,
0.023750864,
-0.01695738,
-0.03257186,
-0.0054670433,
0.007418853,
-0.013330238,
0.037574813,
0.02485678,
-0.008103468,
0.0014745548,
0.009551692,
0.01765516,
-0.0051115705,
-0.024790952,
-0.0024965396,
0.01586463,
-0.0062471093,
-0.013507974,
-0.02072276,
0.00069778034,
0.0053189294,
-0.0263445,
0.016917882,
-0.022342138,
-0.013330238,
-0.011776689,
0.0019040846,
-0.0011758587,
0.013916111,
0.0051938556,
0.0033605366,
-0.016312262,
-0.017405013,
-0.01252055,
0.01747084,
0.0039200773,
0.022039328,
0.012961599,
-0.0027006075,
0.0035316902,
0.006046333,
-0.0063952226,
-0.015509156,
-0.017523503,
0.04002363,
0.005569077,
0.000058576934,
-0.0063623087,
-0.0069778035,
0.018458266,
-0.03178192,
0.0027252932,
-0.01981433,
-0.007675584,
-0.011908346,
0.021249387,
0.0010927503,
-0.0023796943,
-0.005746814,
-0.023685034,
0.0013889779,
-0.013823951,
-0.01914288,
0.021973498,
-0.029728077,
-0.0022480376,
0.008241707,
0.008241707,
0.013053759,
-0.0115462905,
0.018866401,
-0.027015949,
0.05271533,
-0.037574813,
0.022816101,
-0.008458941,
-0.0040484425,
-0.019748501,
0.0057928935,
-0.0065334626,
-0.017497173,
-0.007313528,
0.0036699297,
-0.016996877,
-0.019011224,
-0.009821588,
0.0068724784,
0.0026512363,
-0.02153903,
0.022723941,
0.014758713,
0.0070897117,
-0.01586463,
-0.00397274,
0.041524515,
-0.0031531772,
-0.003396742,
0.031202631,
-0.0054769176,
0.0069975522,
-0.0005583066,
-0.0075439275,
0.007715081,
-0.0011552873,
-0.021618025,
0.004683686,
0.01586463,
-0.019709004,
-0.018089626,
0.00049864966,
-0.021776013,
-0.008360199,
-0.0020916953,
0.010552282,
-0.006474217,
-0.016746728,
-0.009867667,
-0.012342813,
0.004864714,
-0.015746137,
-0.006207612,
0.00852477,
0.013507974,
-0.019801164,
0.0011766815,
-0.012882605,
0.032203224,
-0.0036600556,
-0.0048943367,
-0.0039859056,
0.024093172,
-0.04044493,
-0.01233623,
-0.023908852,
0.011921512,
-0.0015881086,
-0.0056217397,
0.0015815258,
0.010604945,
-0.01263904,
0.03494168,
-0.0193272,
-0.0072542825,
0.0115002105,
-0.010400877,
0.019682672,
-0.0060068355,
-0.025027933,
0.006513714,
0.020433115,
0.013139335,
-0.013600134,
0.0021673979,
0.004910794,
0.000057754078,
0.0005801122,
0.002624905,
-0.0028750526,
-0.01203342,
0.0020176384,
0.0058653047,
0.00913039,
0.02862216,
0.00022134779,
0.015035192,
0.0032634398,
0.032203224,
0.00087222544,
-0.012441555,
0.011763523,
-0.026410328,
0.020143472,
-0.013494809,
0.010137564,
0.020946577,
-0.013547472,
-0.004476327,
0.007359608,
-0.024014177,
-0.022618616,
-0.004305173,
0.006793484,
-0.0064182626,
-0.007590007,
0.010552282,
-0.017233858,
0.011756941,
0.0034757361,
-0.008070554,
-0.0065433364,
-0.01747084,
-0.0038509576,
-0.007010718,
0.0071884543,
0.010532534,
-0.024777785,
-0.016759895,
0.015693475,
-0.035073336,
-0.0051082787,
-0.0035020674,
0.007353025,
-0.026686808,
0.004199848,
0.007010718,
-0.009525361,
0.0063787657,
-0.018129123,
-0.027147606,
-0.0020077643,
0.01598312,
0.19443057,
-0.023803527,
-0.021683853,
0.0038410835,
-0.010335049,
-0.007932315,
-0.020143472,
-0.0068066497,
-0.017273355,
0.019116549,
0.022802936,
-0.0058850534,
0.016035782,
0.0069448897,
-0.005898219,
-0.0020472612,
-0.0245803,
-0.004492784,
-0.0074122706,
-0.011045995,
-0.01649658,
-0.016272765,
0.026594648,
-0.0006187864,
0.039497003,
-0.016746728,
-0.016364925,
0.009275213,
0.027173936,
-0.00078994,
-0.012303316,
0.0069975522,
0.011796438,
0.0023220945,
-0.013349987,
0.0110262465,
0.0024932483,
-0.0114541305,
0.009314709,
0.0012351042,
-0.0024076714,
0.01635176,
-0.02558089,
0.005503249,
-0.0061022867,
0.022289475,
-0.010835344,
-0.029675413,
-0.006704616,
-0.013837116,
-0.021460038,
0.008544518,
-0.016009452,
0.027805889,
0.0020703012,
-0.005147776,
0.017418178,
0.02901713,
-0.010611528,
0.013277575,
0.0015058232,
0.005875179,
-0.032492865,
0.02093341,
-0.02564672,
0.02822719,
-0.040286943,
0.0044269557,
-0.011335639,
-0.015574984,
0.010532534,
-0.012704869,
-0.028753817,
0.018774241,
-0.008913157,
0.0035086502,
0.023553379,
0.009044813,
0.02023563,
0.015219511,
-0.0048054685,
-0.019577347,
-0.029359438,
-0.007701915,
-0.010552282,
-0.056717694,
0.024356484,
-0.0018942103,
-0.03828576,
-0.011803021,
0.006513714,
-0.012191407,
-0.005526289,
-0.011947843,
0.01914288,
-0.004262385,
0.0048712967,
-0.021473203,
-0.008156131,
0.017668325,
-0.028095534,
0.07994193,
-0.0061187437,
0.0019962443,
-0.010868258,
0.01719436,
-0.01470605,
-0.00059327786,
0.020038145,
-0.013850282,
0.007866486,
-0.0076558352,
0.0011725673,
-0.031650264,
-0.01400827,
0.02406684,
0.020433115,
0.004430247,
0.019801164,
0.00046573547,
-0.0055855345,
-0.004324922,
0.010907755,
0.0051708156,
0.009689931,
0.0031136803,
-0.018102793,
0.03078133,
-0.005519706,
-0.039602328,
0.00041410138,
-0.0073069455,
-0.0029622752,
-0.006582834,
0.0072937794,
0.009459532,
-0.009248882,
-0.02367187,
-0.025093762,
0.023790361,
-0.0145612275,
0.0134289805,
0.015574984,
0.016088445,
-0.0010022364,
-0.022579119,
0.00996641,
-0.012560046,
-0.008998734,
-0.021644358,
-0.017391846,
-0.023197906,
0.0022134779,
0.0051115705,
0.022486959,
-0.043288715,
-0.0037225925,
-0.018774241,
0.0035514387,
-0.0053650094,
-0.030544348,
0.0027614988,
0.022671279,
0.011329057,
0.01500886,
-0.007227951,
-0.16430752,
0.013823951,
-0.0033835764,
0.0039924886,
0.03941801,
0.0053485525,
-0.014153092,
0.028095534,
0.00859718,
0.005592117,
0.0505035,
0.008926323,
-0.023566544,
0.022197315,
0.014416406,
0.0010730019,
-0.022868764,
0.027068611,
0.027463581,
-0.004473035,
0.029148787,
-0.038628068,
0.016549245,
-0.02221048,
0.005032576,
0.026607813,
0.011223732,
0.0007179403,
-0.0045454465,
-0.025633555,
-0.017326018,
-0.016127942,
0.052610006,
-0.0076887496,
0.009538526,
-0.0053222207,
0.00321736,
-0.02594953,
0.023250569,
0.019472022,
0.037416827,
0.036389906,
0.014534896,
0.016996877,
-0.0355473,
0.008972402,
-0.008636678,
-0.008419444,
0.027200269,
0.0022282891,
0.014771879,
-0.0005196324,
0.0037390494,
0.033625115,
0.009393703,
0.0047198916,
-0.01568031,
-0.00093311665,
-0.0061714067,
-0.0104601225,
-0.0023945058,
-0.025910033,
-0.018115958,
-0.0073003625,
0.023908852,
-0.03552097,
-0.006270149,
0.0018925647,
-0.014363743,
0.007629504,
-0.017720988,
-0.030544348,
0.013422398,
0.0018234449,
0.019406194,
0.013396067,
-0.015390665,
0.010901173,
0.006444594,
0.008445775,
-0.03020204,
-0.0017855936,
-0.028674822,
0.0020390328,
-0.02643666,
-0.003679804,
-0.0034263649,
0.0069580553,
-0.017799983,
-0.0062010293,
0.012441555,
-0.019643176,
-0.010828761,
0.0045026583,
0.020485777,
0.038338423,
0.0035218159,
-0.008788083,
-0.0153116705,
-0.0060529155,
0.007932315,
-0.023369059,
-0.018879566,
0.004262385,
0.03612659,
-0.002675922,
-0.013534306,
0.0022217063,
0.05977213,
-0.025515063,
-0.0065696677,
-0.0021114438,
0.00992033,
0.037943453,
0.0029951893,
0.020261962,
-0.00012085671,
-0.0077677434,
0.029833402,
-0.028095534,
0.07098928,
0.0037291753,
-0.008570849,
0.034230735,
-0.0040122373,
-0.0014235377,
-0.13228862,
-0.021868173,
0.005338678,
0.025883703,
-0.01719436,
-0.012132162,
-0.020433115,
0.0061187437,
0.0046705203,
0.012276985,
0.013224913,
-0.018642584,
-0.0015255717,
0.0085774325,
0.020670097,
-0.0059442986,
0.018919064,
-0.0056283227,
-0.011618702,
0.015785635,
0.010637859,
-0.0077282465,
0.0206306,
-0.009183053,
0.007978395,
-0.012000506,
-0.02878015,
0.027463581,
0.0076163383,
0.013303907,
0.031413283,
0.0064478857,
-0.008149548,
-0.013573803,
-0.0037028438,
0.015272174,
0.0065663764,
-0.01635176,
0.036679547,
-0.031650264,
0.009202802,
0.00078130007,
0.01628593,
-0.0022299348,
0.024777785,
-0.00520373,
-0.03041269,
0.007813823,
0.018010633,
-0.017523503,
-0.033467125,
-0.04202481,
-0.042577766,
0.0067210733,
0.010532534,
-0.001969913,
-0.014482234,
0.043499365,
-0.014508565,
-0.004153768,
-0.0024866655,
-0.00315976,
-0.010249472,
0.006316229,
0.00759659,
-0.021802345,
0.0043150475,
-0.031808253,
0.01549599,
-0.0320979,
0.0024619799,
-0.009242298,
-0.008261456,
-0.008235125,
-0.03433606,
0.0029721493,
-0.0053419694,
-0.011355388,
0.0027516244,
-0.01765516,
-0.00882758,
-0.000629072,
0.018629419,
-0.03270352,
0.020841252,
0.03981298,
0.006576251,
-0.017799983,
-0.02160486,
0.0018464848,
-0.012395476,
0.01303401,
-0.0071752886,
-0.003115326,
-0.008880243,
0.0015527259,
-0.019643176,
0.0038443748,
0.024316987,
0.02494894,
-0.009933496,
-0.026015358,
-0.047212083,
0.0040978137,
0.006043041,
0.013132753,
0.0035843528,
0.006918558,
0.0043973327,
0.0049371254,
0.029069792,
0.05466385,
-0.016536077,
0.03215056,
0.006049624,
0.0068724784,
-0.024962105,
0.0022628491,
0.021183558,
0.031044643,
-0.0039134948,
0.0122045735,
-0.0040155286,
0.0064182626,
0.009795256,
0.04439463,
-0.014627056,
0.0028009957,
-0.0052629756,
0.022592286,
-0.018734744,
-0.015469659,
0.0136132995,
-0.029280445,
-0.006579542,
0.0018612962,
0.0055789514,
0.0006150835,
0.0042031393,
0.02211832,
0.0022562663,
0.029280445,
-0.00022299349,
-0.029754408,
0.008399696,
-0.01470605,
0.011618702,
0.014284749,
-0.040576585,
0.027358256,
0.008412861,
0.021525865,
0.021038735,
0.012342813,
-0.010651025,
-0.02120989,
-0.01286944,
0.018879566,
0.019616844,
-0.02172335,
-0.008445775,
-0.013889779,
0.039944634,
0.021973498,
0.013916111,
0.0061154524,
0.016325427,
-0.0009791965,
-0.02209199,
0.014429571,
0.021525865,
-0.03473103,
0.008768334,
-0.02573888,
0.014442737,
0.010177061,
0.016299097,
0.028253522,
-0.005338678,
0.021855008,
0.017207528,
0.025488732,
0.0058225165,
-0.005315638,
-0.035889607,
-0.013744957,
0.027595239,
0.010262637,
0.009604354,
0.017089035,
0.0038114607,
0.013731791,
-0.01953785,
0.0210914,
-0.0063623087,
-0.012118997,
0.0026545275,
0.03536298,
0.014179423,
0.004324922,
-0.014929866,
0.026318168,
-0.012836525,
0.011315891,
0.004611275,
-0.027200269,
-0.01704954,
0.006553211,
-0.036021266,
-0.033440795,
-0.024264324,
0.01440324,
0.011388302,
0.020130305,
0.00429859,
-0.0079652285,
-0.02880648,
0.023895686,
-0.023329562,
-0.011408051,
-0.010815595,
0.011315891,
0.012586378,
0.0139029445,
-0.023750864,
-0.011467296,
-0.011355388,
0.0026775675,
0.025238585,
-0.007952063,
0.025172755,
-0.0021855007,
0.0063688913,
0.029859733,
-0.029886065,
-0.020011814,
0.020893915,
-0.0133368205,
0.022236811,
-0.003138366,
-0.02683163,
0.06835614,
-0.0063985144,
-0.023237403,
0.020498944,
-0.02142054,
0.018234449,
0.0015362687,
0.02494894,
0.016272765,
-0.024106337,
0.01972217,
-0.014245252,
0.008366781,
-0.025567725,
-0.026476156,
0.011947843,
0.002850367,
-0.016233267,
0.014903535,
-0.009446366,
0.005898219,
-0.014824541,
-0.0036765125,
-0.0017872393,
-0.028753817,
0.008221959,
0.047133088,
0.0054769176,
0.012803611,
-0.023342729,
0.0034757361,
-0.020986073,
-0.02464613,
-0.014416406,
0.011302725,
-0.012625875,
-0.017391846,
-0.013981938,
0.013178833,
0.010400877,
-0.013837116,
0.018563591,
-0.016838888,
-0.031413283,
-0.0070238835,
-0.008063971,
-0.00007261688,
-0.025449235,
-0.032466535
] |
BACKGROUND Age-specific effects of mammographic screening, and the timing of such effects, are a matter of debate. The results of the UK Age trial, which compared the effect of invitation to annual mammographic screening from age 40 years with commencement of screening at age 50 years on breast cancer mortality, have been reported at 10 years of follow-up and showed no significant difference in mortality between the trial groups. Here, we report the results of the UK Age trial after 17 years of follow-up. METHODS Women aged 39-41 from 23 UK NHS Breast Screening Programme units years were randomly assigned by individual randomisation (1: | [
-0.025196306,
-0.03928567,
0.019308599,
-0.050855402,
-0.011319055,
0.0039787022,
-0.028821489,
-0.001524955,
-0.04185672,
-0.01103624,
-0.01466785,
0.007057537,
-0.004795011,
0.0008902266,
-0.022470992,
0.01743173,
0.03591759,
0.022740953,
0.0072760764,
-0.006324787,
-0.028718647,
0.008542319,
-0.022445282,
0.007057537,
-0.009056529,
-0.0049364194,
0.015014942,
-0.03296088,
0.0021805733,
-0.001852764,
0.034889173,
0.013292337,
-0.011132654,
-0.010624871,
-0.021249741,
0.0063119316,
0.009673581,
-0.015259191,
0.0083944835,
-0.0144235995,
-0.009448615,
0.0008797817,
-0.0019700683,
-0.0007986329,
-0.006755438,
0.016364744,
0.01691752,
-0.009255786,
-0.032035302,
0.020516992,
-0.0064597675,
-0.0148992445,
-0.02694462,
0.010335628,
-0.01865298,
-0.022291018,
-0.014127929,
0.033937883,
0.004798225,
0.000705834,
0.0025694447,
-0.016737547,
-0.008818707,
-0.004679314,
-0.0020857656,
-0.013896534,
0.0051260344,
0.018910086,
-0.0039722747,
0.02092836,
0.03396359,
0.04231951,
-0.00032941598,
0.019321453,
-0.0038855018,
-0.0084073385,
-0.0077774315,
-0.0131445015,
0.0029406403,
-0.00471788,
0.016300468,
0.0025758725,
-0.0050778273,
0.017637415,
0.0041136825,
0.018447295,
0.014577863,
0.01816448,
0.013510876,
0.009660726,
0.008278786,
0.00005558895,
0.006498333,
0.017277468,
-0.018768677,
-0.0031286485,
0.002302698,
0.017444586,
0.00043828395,
-0.007899556,
-0.009911404,
-0.012848831,
0.008156661,
0.003225063,
-0.022252452,
0.00018489477,
-0.016043363,
-0.00087817485,
0.008368773,
-0.03337225,
-0.00997568,
0.03537767,
-0.019591413,
-0.017174626,
0.015349179,
-0.02691891,
-0.014217916,
0.0050938963,
-0.009583595,
0.0014687133,
0.020259887,
-0.009191509,
0.034760617,
-0.024116464,
0.02518345,
-0.0015281688,
-0.018280176,
-0.002063269,
0.0073596356,
0.00021432126,
0.0024907063,
-0.019887084,
0.015194915,
0.024335004,
-0.026636096,
0.019308599,
-0.005219235,
-0.012116081,
-0.022303874,
-0.035480514,
0.009165799,
0.029695647,
-0.010226358,
-0.033577934,
-0.020234177,
0.017611705,
0.027407411,
0.022728097,
-0.012514594,
-0.0048817843,
-0.03244667,
-0.006659024,
-0.010830555,
0.0020038134,
0.021969637,
-0.0042904424,
0.0017177839,
-0.0028988607,
-0.040185537,
-0.011132654,
0.0182159,
0.017663125,
0.0037923013,
0.022522412,
0.013870824,
0.016968941,
0.013832258,
0.0045121955,
0.014385034,
0.0069546946,
-0.0067168726,
0.03391217,
-0.013202351,
0.019488571,
-0.008696582,
0.02168682,
-0.015657704,
0.018370165,
-0.03038983,
-0.01816448,
-0.031701066,
0.009859983,
0.00894726,
0.02097978,
-0.029772779,
0.0013040053,
0.0024200024,
-0.0014606788,
0.004994268,
-0.03537767,
-0.005216021,
0.028512962,
0.00006949874,
-0.010014246,
-0.64502543,
-0.012887397,
0.0035319822,
0.0049974816,
-0.008143806,
0.01244389,
0.008760858,
0.008902267,
-0.03085262,
0.02686749,
-0.0024858855,
0.01914148,
0.011916825,
-0.00083077105,
-0.010959107,
-0.02635328,
-0.012379614,
-0.0097121475,
0.018318743,
0.0021725385,
-0.016981795,
0.033166565,
-0.003017772,
0.034606356,
-0.00759103,
0.007815997,
0.013138074,
-0.03478633,
-0.0029229643,
0.042036694,
0.004104041,
0.0043032975,
0.009339346,
0.023897925,
0.031778198,
-0.015554863,
0.0017933085,
0.015606283,
0.0021902146,
0.009339346,
-0.009371484,
0.009834273,
0.03437496,
-0.0025389136,
-0.020427005,
0.01819019,
-0.0038244394,
0.01960427,
0.01989994,
-0.007378918,
0.017316032,
0.036071856,
-0.009962825,
0.0064051324,
-0.001508886,
0.002669073,
0.017650269,
-0.01889723,
-0.00465039,
-0.014860678,
-0.010811272,
0.017290322,
-0.007192517,
-0.00505533,
-0.024579253,
0.041702457,
0.01691752,
0.027715936,
0.0068775634,
-0.013639429,
0.02637899,
0.027587384,
-0.01748315,
-0.03638038,
0.0383858,
-0.0014871927,
0.01792023,
0.009249358,
0.0039112126,
0.0010163689,
0.008304497,
0.009043674,
-0.021583978,
0.033706486,
0.0025453412,
-0.018074494,
-0.0071153855,
-0.0018913299,
-0.012514594,
0.006999688,
0.0035769755,
-0.0127074225,
0.00009174436,
-0.040596906,
-0.0032877324,
-0.015323468,
0.010078522,
0.006639741,
-0.004020482,
-0.03730596,
-0.031675357,
0.021481136,
0.005424919,
0.012829548,
0.038514353,
-0.005662741,
-0.042705167,
-0.0040333373,
0.052629426,
-0.01792023,
0.028718647,
0.006462981,
-0.0040976135,
-0.0067618657,
-0.0013345365,
-0.02491349,
0.002477851,
0.0216354,
0.009930687,
0.0026401486,
0.024489267,
0.0013771196,
0.03283233,
-0.020324163,
0.014654995,
0.037357382,
-0.006205876,
0.023203742,
-0.0051742415,
-0.015901955,
0.002879578,
0.009223647,
-0.0067490106,
-0.005968054,
0.01816448,
-0.006864708,
0.005772011,
-0.018305888,
0.0048657153,
-0.013099508,
-0.039954145,
0.0053799255,
-0.000063020896,
-0.00075163087,
-0.0011553663,
-0.020427005,
-0.025491977,
0.00596484,
0.0010002998,
-0.0006857477,
-0.02388507,
0.0016310109,
0.02589049,
0.0007873846,
-0.007488188,
0.002117904,
0.020285597,
-0.012913107,
-0.008034537,
-0.0154006,
0.016853243,
-0.00658832,
-0.032678068,
-0.016467586,
0.016249046,
-0.016930375,
-0.002669073,
0.014217916,
0.010971963,
-0.019784242,
0.002527665,
-0.012154647,
0.0054666987,
-0.0061448133,
0.002117904,
-0.0035094856,
0.00092316826,
0.0008175141,
-0.022560978,
-0.007282504,
0.017238902,
-0.0131573565,
0.00978928,
-0.0005792901,
0.0557404,
0.040031273,
0.01965569,
-0.029644225,
-0.03134112,
0.023525123,
-0.016788967,
0.012643146,
-0.011306199,
-0.0037344526,
-0.00133534,
-0.02564624,
0.0013939921,
-0.026996043,
0.032163855,
0.005457057,
0.023319438,
-0.00658832,
0.03890001,
-0.0019989926,
-0.0028667226,
-0.002342871,
0.036046144,
0.0031623936,
0.012392469,
-0.008330207,
0.009525746,
-0.015914809,
0.0074624773,
0.009062957,
0.0016020866,
-0.010419187,
0.009146516,
-0.0063922773,
-0.018550137,
0.002167718,
-0.011106943,
-0.0065947473,
0.022869505,
0.0051067513,
-0.012752417,
0.0196814,
0.024090754,
0.0033680776,
-0.00088058517,
-0.013652285,
-0.012521022,
0.009731431,
-0.011177647,
0.038822882,
0.0057623694,
0.01865298,
0.009635016,
-0.004576472,
0.010509173,
0.02586478,
0.003965847,
-0.011743278,
0.03185533,
0.0077581485,
0.0067940042,
-0.023010913,
0.015439165,
0.008754431,
0.0010525243,
-0.016711837,
-0.012880969,
0.015297757,
-0.023563689,
0.016519006,
-0.0033487948,
-0.0009906583,
-0.0061415997,
0.010644154,
0.004190814,
0.035763327,
0.047178797,
0.029181436,
-0.0062123034,
-0.0036991006,
0.011813982,
-0.02060698,
0.027587384,
0.008130951,
0.0026819282,
-0.01884581,
-0.00068815803,
-0.020748386,
0.012482456,
-0.0398513,
0.015079218,
0.0008022485,
0.01957856,
0.014924955,
0.01865298,
0.007205372,
-0.034709197,
-0.03344938,
0.027638806,
0.01721319,
-0.011479746,
-0.017637415,
0.009795707,
-0.021429716,
0.004367574,
-0.010387049,
0.0028297638,
0.01862727,
-0.020696966,
0.016570428,
-0.005007123,
-0.000115094736,
0.00035954552,
-0.004332222,
0.0016189591,
0.0023798298,
-0.0033359395,
-0.0018865091,
0.015362034,
-0.021571124,
0.0030563376,
-0.00027096475,
0.0015104929,
-0.027484542,
-0.007661734,
0.0042229523,
0.0025373066,
-0.022458136,
-0.01567056,
0.018331598,
0.022946635,
0.022972347,
0.01046418,
-0.02518345,
-0.0060773236,
-0.0023268017,
-0.0053027943,
-0.023975058,
-0.03131541,
-0.024514977,
0.059802663,
0.0070189713,
0.008265931,
-0.003120614,
-0.013716561,
0.017804533,
0.0004451133,
-0.016647559,
0.0148992445,
0.039517064,
-0.0045636166,
0.008098813,
0.03974846,
0.011563305,
0.008323779,
0.027098885,
0.018742967,
-0.0049974816,
-0.0036058999,
-0.0076938723,
0.01914148,
0.0028345846,
0.029464252,
0.03769162,
0.010232786,
-0.021802519,
0.006883991,
0.019270033,
-0.010380621,
-0.010528456,
-0.010322773,
0.020118479,
0.01466785,
0.02171253,
0.012572442,
0.004730735,
0.021995347,
-0.0075460365,
0.018987216,
-0.028641516,
0.0020488068,
-0.007314642,
-0.0063472837,
0.008182372,
0.018228756,
-0.011813982,
0.014513587,
0.027433122,
0.014809257,
-0.014050798,
0.03843722,
0.013639429,
-0.028950041,
-0.010515601,
-0.0028586881,
0.02090265,
-0.019282887,
-0.00043265978,
-0.0063280007,
0.0013007914,
-0.016686125,
-0.014385034,
0.010836983,
0.0020873726,
-0.013973665,
-0.024065044,
-0.04990411,
-0.0016061038,
0.0048528602,
0.014822112,
-0.01721319,
-0.003586617,
-0.0053831395,
0.024592109,
0.007398201,
0.024026478,
0.034477804,
-0.009345773,
-0.004158676,
0.031135436,
-0.0013056122,
-0.007899556,
-0.008169517,
-0.020504138,
0.0076295957,
0.0140122315,
-0.0051581725,
-0.028050173,
-0.033475094,
0.012919535,
0.010554167,
0.016416164,
0.026224727,
-0.0058459286,
-0.015503442,
0.0044157812,
0.0110041015,
0.015272046,
-0.012893824,
-0.0074239117,
0.008426622,
-0.014487877,
-0.01219964,
-0.012231778,
-0.023036623,
0.020812662,
-0.010515601,
0.008362345,
-0.01865298,
-0.020234177,
0.008773713,
-0.022560978,
0.019797098,
-0.006292649,
-0.0035416237,
0.023473702,
0.011807554,
0.020889794,
0.022175321,
-0.0067875762,
-0.0020841588,
0.0057109487,
0.025697662,
0.015786257,
-0.010187793,
0.0034966304,
-0.022728097,
-0.0045154095,
-0.026481831,
-0.0055598994,
0.010869121,
0.018987216,
0.0046407483,
-0.04733306,
-0.046587456,
-0.03427212,
-0.0015787864,
0.00070623576,
-0.016056217,
-0.009680009,
-0.013086653,
0.0075781746,
-0.010091377,
-0.023910781,
0.053426452,
-0.018048782,
-0.006620458,
-0.027613094,
-0.017058928,
0.024566399,
-0.0097057205,
0.014320758,
-0.020748386,
-0.00327327,
-0.024990622,
-0.015542007,
-0.002617652,
-0.011319055,
0.03638038,
0.035454802,
0.02214961,
0.008574457,
-0.009609305,
0.017727401,
0.00921722,
0.0064533395,
0.0038340809,
0.033989303,
0.019308599,
0.033089437,
0.0014148819,
0.0031640003,
0.0014904065,
-0.0013489986,
0.019912794,
0.008516609,
-0.009673581,
-0.024797793,
-0.04028838,
-0.033526514,
-0.008870129,
-0.020324163,
-0.0035480512,
-0.0045989687,
-0.048978534,
0.0077067274,
0.021005493,
0.018678691,
0.0030017027,
-0.0037023143,
0.012180357,
-0.01203895,
0.0014518407,
-0.011691857,
-0.023846503,
-0.018280176,
-0.012938818,
-0.025247727,
0.004795011,
0.0004748411,
-0.012244633,
0.017380308,
0.039465643,
-0.014577863,
0.0027269216,
-0.016583283,
-0.041059695,
-0.0065529677,
-0.009808562,
-0.029078593,
-0.0127138505,
0.003602686,
-0.0050617578,
0.01070843,
-0.005951985,
0.020581268,
-0.028847199,
0.021789663,
-0.006360139,
-0.01347231,
0.0033712916,
-0.0027445976,
0.032035302,
-0.0002601181,
0.035403382,
0.03738309,
0.0060226885,
0.002943854,
0.021892505,
0.00079019665,
0.024026478,
0.032703776,
0.03632896,
-0.012906679,
0.023795083,
-0.013292337,
0.015349179,
-0.036611777,
-0.03630325,
0.01995136,
0.009474325,
-0.009898549,
-0.01222535,
-0.01209037,
-0.042473774,
0.012887397,
-0.0035030579,
-0.021995347,
0.016981795,
-0.02637899,
-0.00083880563,
0.015079218,
-0.029592805,
-0.003258808,
0.00054393813,
-0.025530543,
-0.0003012951,
-0.01019422,
0.014487877,
-0.005373498,
-0.0047403765,
0.016467586,
-0.02339657,
-0.015567718,
0.010290634,
-0.005550258,
-0.006029116,
-0.0013980094,
-0.018524427,
0.025196306,
0.0029358196,
-0.01241818,
-0.013986521,
0.015567718,
0.002479458,
0.0012429428,
-0.019887084,
0.00065561815,
-0.013395179,
-0.0060419715,
0.022535268,
0.032626644,
-0.017714545,
-0.0070061157,
-0.024270728,
0.0139351,
0.0007905984,
-0.014809257,
0.003570548,
-0.015284902,
-0.01767598,
-0.0067875762,
0.005360643,
0.03542909,
0.020619834,
0.0016318144,
0.006569037,
0.0153363235,
-0.021558268,
0.010612016,
0.022239598,
-0.025723372,
-0.012257488,
0.013395179,
-0.034554936,
0.0031109725,
-0.0014847823,
-0.011897542,
-0.029952751,
-0.024296438,
-0.009365056,
0.01030349,
0.020054203,
-0.024412135,
-0.0092750685,
0.005135676,
-0.0028329776,
-0.0049781986,
-0.027818779,
0.0066654515,
-0.016069073,
0.0069932607,
0.0017274254,
-0.022843795,
0.007732438,
-0.027253147,
0.015374889,
-0.0050135506,
-0.019064348,
-0.017804533,
0.011049095,
-0.00017595635,
-0.019321453,
-0.0071346685,
-0.04190814,
-0.014577863,
-0.0221239,
0.0298242,
-0.016904665,
0.0067940042,
0.010791989,
0.003946564,
0.0010171724,
0.022021057,
-0.0015225447,
0.016647559,
0.006321573,
-0.010605589,
-0.000476448,
-0.012173929,
0.001733853,
0.039131407,
0.032035302,
0.002672287,
-0.024219306,
-0.017830243,
-0.03481204,
-0.029618515,
0.0008291642,
0.02830728,
0.0153106125,
0.019347163,
0.0032186352,
0.0026674662,
-0.0065079746,
-0.005199952,
-0.03334654,
-0.032523803,
0.0067682937,
-0.016004797,
0.027407411,
-0.0022802015,
-0.0427823,
-0.008259503,
0.029258568,
-0.023705097,
-0.022702387,
0.016506152,
-0.017624559,
0.00009340149,
-0.026584674,
-0.018935796,
-0.008105241,
-0.0009786065,
-0.0054281326,
-0.016313322,
0.01862727,
-0.006337642,
-0.0030804414,
-0.0038565774,
-0.012585298,
0.009782852,
0.0016727905,
0.0018736538,
-0.022303874,
-0.018151624,
0.0007070392,
-0.023435136,
0.023332294,
0.046613168,
0.027690226,
0.02586478,
0.009994963,
0.0068582804,
-0.005810577,
0.005460271,
0.006980405,
-0.025414845,
0.011698285,
-0.005550258,
-0.008960115,
-0.015824823,
-0.01019422,
-0.020478427,
0.0148735335,
-0.029669937,
-0.033038013,
-0.03290946,
0.020992637,
0.012096798,
-0.014732126,
-0.0015787864,
0.01168543,
-0.0308012,
0.0084073385,
-0.009487181,
-0.0047275214,
-0.018035928,
0.006324787,
0.009512891,
-0.012328193,
0.009467898,
-0.0012574049,
-0.005598465,
0.008780141,
0.024463557,
0.17987077,
-0.0023460847,
-0.011177647,
0.017046073,
-0.00313829,
-0.0044222088,
0.032138146,
0.01648044,
-0.0013248951,
0.017007507,
-0.0076167407,
-0.018742967,
-0.011518312,
0.004663245,
0.013793692,
-0.010894831,
-0.008600168,
0.0019298956,
0.01816448,
0.013485166,
0.00859374,
-0.017688835,
-0.0268932,
0.01203895,
0.029644225,
0.026314713,
-0.012765272,
0.007038254,
0.005145317,
0.002043986,
-0.004553975,
-0.016416164,
-0.011788272,
0.013022376,
-0.021918215,
-0.011499029,
-0.017174626,
-0.023717951,
-0.0025469481,
0.008799424,
-0.012745989,
0.03720312,
-0.0056434586,
0.0054988367,
0.0026787145,
0.019295743,
0.015259191,
-0.027458832,
-0.010657009,
-0.012572442,
-0.043887854,
-0.0027462046,
0.0010203861,
-0.021404006,
0.006382636,
-0.016069073,
-0.0069032735,
-0.019115768,
0.003239525,
-0.009866411,
-0.013523731,
-0.010547739,
-0.021404006,
0.007995971,
-0.01862727,
0.039234247,
0.00070663745,
0.014976376,
-0.009307207,
-0.0033327257,
-0.015709126,
0.0077260104,
-0.035017725,
0.014642139,
-0.00039670523,
-0.026584674,
0.0403398,
0.012784555,
0.020619834,
0.00015898338,
-0.002614438,
0.01070843,
0.002669073,
0.015040652,
-0.010335628,
-0.027098885,
-0.0039015708,
0.028101595,
0.013202351,
-0.0092814965,
-0.00821451,
-0.025659095,
-0.001627797,
-0.0050328337,
0.0030370548,
0.006186593,
0.012758844,
0.041702457,
-0.014616429,
-0.0048592878,
-0.019539993,
0.06216803,
-0.0055920375,
0.008523037,
0.010779134,
-0.014282192,
-0.03427212,
0.048052955,
-0.00596484,
-0.0023685812,
0.012353904,
-0.023062333,
0.018100204,
-0.012167502,
-0.0005555882,
0.032626644,
0.0022625255,
-0.012450318,
0.0066461684,
-0.022008203,
-0.017264612,
-0.022560978,
0.013343758,
0.03038983,
0.0045121955,
-0.033526514,
-0.015477731,
-0.0073917736,
-0.0034355677,
-0.017238902,
-0.012970956,
-0.017393164,
-0.014577863,
-0.0042872285,
0.006135172,
-0.012424607,
0.0066525964,
-0.014217916,
-0.0109912455,
0.022303874,
-0.0026658592,
-0.013922244,
0.010541311,
0.0037665907,
-0.009583595,
-0.02366653,
-0.0038051566,
0.017624559,
-0.01366514,
0.010219931,
-0.014217916,
-0.010965535,
0.0022094976,
-0.002148435,
0.0476673,
-0.018935796,
-0.017650269,
-0.029155726,
-0.021172611,
0.017637415,
-0.0003145521,
-0.00908224,
0.03473491,
-0.00921722,
0.005823432,
0.03478633,
-0.16043362,
0.0010444898,
0.016416164,
-0.018254466,
0.038000144,
-0.024065044,
0.016313322,
0.0062348004,
-0.020851228,
-0.010052812,
0.039671328,
-0.00062749727,
-0.004624679,
-0.016737547,
0.0030065235,
-0.0050617578,
-0.00845876,
0.04368217,
0.017508863,
0.008355918,
0.02022132,
-0.030441253,
0.010779134,
-0.011293344,
0.0063633528,
0.0033841468,
0.00797026,
0.020285597,
-0.017560283,
-0.002117904,
-0.029721357,
0.015297757,
0.013819403,
-0.016840389,
-0.01117122,
-0.00029908563,
-0.017997362,
-0.024360714,
-0.019295743,
0.006446912,
0.03082691,
0.017033217,
-0.017688835,
-0.005945557,
0.0047564455,
0.024579253,
0.020709822,
-0.004329008,
0.015966231,
-0.003760163,
0.012360331,
-0.026996043,
0.021815373,
0.0048657153,
-0.025144884,
0.002669073,
-0.0061094617,
-0.017804533,
0.021982491,
-0.008182372,
-0.0139351,
-0.0069868327,
0.0268932,
0.0064083464,
-0.01884581,
-0.020208467,
-0.013819403,
0.024052188,
-0.0064436984,
-0.003689459,
-0.011756133,
-0.0044350643,
0.01466785,
-0.026404701,
0.041419644,
0.022188175,
-0.009474325,
-0.01144118,
0.011679002,
-0.0028377983,
0.000792607,
0.038025852,
-0.028847199,
0.010676292,
-0.012424607,
0.0049299914,
-0.0013329296,
0.011749706,
-0.006710445,
-0.017984506,
0.0131445015,
-0.024232162,
-0.0011979494,
-0.004348291,
0.00567881,
0.014513587,
-0.026558964,
-0.0048078666,
-0.012855259,
-0.05021264,
0.014770692,
-0.0191929,
-0.012212495,
0.027844489,
0.03974846,
-0.016788967,
0.00696755,
-0.006485478,
0.012392469,
-0.0044350643,
-0.012611008,
0.0005258604,
0.011640436,
-0.004438278,
-0.0073917736,
0.028564384,
0.01667327,
-0.017547427,
0.005547044,
-0.0010693969,
0.039105695,
0.010965535,
0.01230891,
0.014680705,
0.007918839,
0.00805382,
-0.10099091,
-0.013099508,
0.01046418,
0.035506222,
0.0122896265,
0.0025340929,
-0.0058973497,
0.029541384,
0.0140379425,
0.03149538,
-0.006620458,
-0.007931694,
-0.029901331,
0.00045073748,
0.023872215,
-0.041085407,
-0.017753111,
-0.041933853,
-0.022381004,
0.027407411,
-0.01119693,
-0.03432354,
0.01648044,
-0.02160969,
-0.019552847,
-0.031546805,
-0.020259887,
0.030312698,
0.012257488,
0.020478427,
0.014269337,
-0.01520777,
-0.007783859,
-0.0066847345,
-0.023576545,
-0.023293728,
-0.013266627,
-0.02263811,
0.020247031,
-0.015272046,
-0.012353904,
0.015991941,
0.02209819,
0.0026787145,
0.010014246,
-0.027793068,
-0.006620458,
0.017585993,
0.004521837,
-0.0033038014,
-0.00603233,
-0.015516297,
-0.01865298,
-0.007192517,
-0.0013835472,
-0.0127138505,
0.013459455,
-0.033577934,
-0.022303874,
-0.0050649717,
-0.012559587,
0.010399904,
-0.009615733,
0.023962202,
0.019180045,
-0.012938818,
-0.008773713,
0.008523037,
-0.012212495,
0.0123024825,
-0.001248567,
0.0053349324,
-0.011691857,
0.014989231,
-0.022496702,
0.015413455,
-0.02694462,
0.0012799017,
0.016467586,
-0.019244323,
0.012456745,
-0.010380621,
-0.0012461566,
-0.0056434586,
0.027973043,
-0.0023171604,
-0.011730423,
-0.0114540355,
0.0019861374,
-0.009403622,
0.006119103,
0.052578006,
-0.0070189713,
-0.021262597,
-0.013395179,
0.036663197,
0.004232594,
-0.011344765,
0.029027173,
0.009294352,
-0.05075256,
0.0043418636,
-0.05969982,
0.02887291,
0.025119174,
-0.0056048925,
0.009403622,
0.021532558,
0.041985273,
-0.020375585,
-0.0026064035,
0.023242308,
-0.017418874,
0.046176087,
-0.024386425,
-0.00073917734,
0.006864708,
-0.0062830076,
0.008722293,
0.016274758,
0.036020435,
0.038771458,
0.012463173,
0.017933086,
0.009448615,
-0.009185082,
-0.00634407,
0.014243626,
-0.013755127,
0.0016840388,
-0.012566015,
0.016030507,
0.028667226,
-0.0053285044,
0.0050906823,
0.0012710637,
0.0056884517,
-0.029078593,
-0.011813982,
0.0029711716,
-0.0032379183,
0.004174745,
0.0031848901,
-0.015027797,
0.014822112,
-0.02195678,
-0.021493992,
-0.0076553063,
-0.016634705,
0.014243626,
-0.004194028,
-0.0014197025,
0.029130016,
-0.024772083,
0.0055277613,
-0.027587384,
0.0009946756,
-0.0019138266,
0.006845425,
-0.02312661,
-0.010374193,
-0.033243697,
0.019475717,
0.017534573,
-0.012334621,
-0.0011039453,
0.014719271,
-0.04221667,
-0.02694462,
0.021918215,
-0.006430843,
-0.009879266,
0.008381628,
-0.008015254,
-0.00071226165,
0.022998057,
0.008163089,
-0.017585993,
-0.03632896,
-0.0017081425,
-0.0062797936,
0.013883679,
0.0028651156,
0.004730735,
-0.0050135506,
0.0022946636,
0.021211177,
0.023910781,
-0.01987423,
-0.0118396925,
-0.008233793,
-0.006928984,
0.010483463,
0.013330903,
0.024309294,
-0.0022336012,
-0.005948771,
0.027278857,
0.025209162,
0.007867418,
0.0031463245,
0.032086726,
-0.007610313,
0.009152944,
-0.0298242,
-0.018074494,
0.0024039333,
0.0092622135,
-0.008118096,
-0.053169347,
-0.008362345,
0.020542704,
0.0065272576,
0.019334309,
-0.00654654,
0.00892155,
-0.004351505,
0.023319438,
0.0037665907,
-0.007603885,
-0.01965569,
0.03527483,
-0.0058459286,
-0.00038405083,
-0.00053710875,
-0.009493608,
0.034452092,
-0.008201655,
0.031006884,
-0.04077688,
0.012096798,
-0.010522029,
-0.0038019426,
-0.01008495,
-0.020696966,
-0.005084255,
0.005633817,
-0.013202351,
0.01691752,
0.014963521,
-0.017830243,
0.070601076,
-0.015580573,
-0.0043257945,
-0.0030434823,
-0.012045377,
-0.0015803933,
0.011383331,
0.0044286363,
-0.02171253,
-0.017688835,
-0.007995971,
-0.0022480632,
0.01594052,
-0.033243697,
-0.008953688,
0.0052931528,
0.0060226885,
0.02637899,
-0.0054345606,
-0.012540304,
0.029772779,
-0.022830939,
0.003464492,
0.008298069,
-0.027227437,
-0.0023637607,
0.0038726465,
0.012083943,
0.008953688,
-0.014796402,
0.001075021,
0.015040652,
0.0022094976,
-0.015259191,
0.027227437,
-0.01642902,
-0.016004797,
-0.024694951,
-0.007378918,
-0.0031238277,
-0.009769997,
0.022059623,
-0.018820098,
-0.012360331,
-0.019360019,
-0.011351193,
0.006382636,
-0.0014405923,
-0.004769301
] |
BACKGROUND AND AIMS We adopted the twin method to disentangle the genetic and environmental components of susceptibility to coeliac disease (CD). We estimated disease concordance rate by zygosity and HLA genotypes, discordance times, progression rates to disease, and heritability. METHODS We crosslinked the Italian Twin Registry with the membership lists of the Italian Coeliac Disease Association and recruited 23 monozygotic (MZ) and 50 dizygotic (DZ) twin pairs with at least one affected member. Zygosity was assigned by DNA fingerprinting, and HLA-DQ and DR alleles were genot | [
-0.01284451,
0.013521963,
0.029211776,
-0.042598248,
-0.030702172,
0.030647976,
0.009193038,
0.0040647183,
-0.03045829,
-0.03235516,
-0.008407192,
0.008759468,
0.012248351,
0.010602141,
-0.01674664,
0.021895284,
0.044034448,
0.008515585,
-0.0038377715,
0.0055009187,
-0.023006305,
0.003627761,
0.012702245,
-0.021136535,
-0.0133526,
0.020133905,
0.029211776,
-0.014253613,
-0.0074248854,
-0.004925084,
0.008542683,
0.014754928,
-0.020757161,
0.0045152246,
-0.00952499,
-0.025336744,
0.01617758,
-0.0032670174,
0.025607726,
-0.0010212605,
-0.00052121544,
0.00379035,
-0.007648445,
0.0051350943,
-0.011354113,
0.007458758,
-0.018873842,
-0.008190407,
-0.018087996,
0.0052163885,
-0.0020645382,
0.023575367,
-0.011835105,
0.013901337,
-0.013508414,
-0.0013955534,
0.015784657,
0.016096285,
-0.0066322656,
-0.02785687,
-0.0122212535,
-0.0015987892,
-0.02829044,
-0.0045931316,
-0.005409463,
-0.0025167381,
-0.0027673957,
-0.00024663526,
0.015107203,
-0.014795575,
0.022437245,
0.0096130585,
0.0016064106,
-0.021095889,
0.039671652,
0.007479082,
-0.011537026,
-0.010073727,
-0.017505387,
0.013515188,
0.017667975,
0.0044745775,
0.014754928,
0.021244928,
0.0048573385,
-0.0069913156,
0.0011830024,
0.023683758,
-0.008745919,
-0.004562646,
-0.026447767,
0.013149364,
0.013847141,
0.0044915136,
-0.0027352166,
-0.0038987424,
0.014253613,
0.023250189,
-0.019551296,
-0.0035735648,
-0.011177976,
0.019849375,
0.0025658535,
-0.025648372,
-0.01628597,
-0.012438038,
0.0019273539,
-0.021109438,
-0.0022745486,
-0.018142194,
0.011611545,
0.04549775,
0.00014088907,
-0.008745919,
0.01819639,
-0.027883967,
0.014700731,
-0.0054060756,
-0.0052163885,
0.02539094,
0.021434614,
0.01471428,
0.009843393,
-0.013664228,
0.03625729,
0.032788727,
-0.05571374,
-0.00292321,
-0.011252495,
0.0011042485,
0.007241973,
0.011923173,
0.0034431552,
0.023616014,
-0.026745846,
0.010304061,
-0.008996577,
-0.010155021,
-0.010622464,
-0.0007202173,
0.010459876,
0.043275703,
-0.008901733,
-0.0068524377,
0.01571691,
0.037287015,
0.027883967,
0.018223487,
-0.004328925,
0.001050899,
0.008474938,
-0.0009712983,
-0.0015047926,
0.010886671,
0.024022486,
0.031948686,
0.0043323124,
0.0032399192,
-0.03349328,
-0.010134698,
-0.0252419,
-0.0060699796,
-0.008244604,
0.010879897,
0.015554322,
0.028398832,
0.007445209,
-0.013684552,
0.018792547,
-0.014212965,
-0.013982631,
-0.00042616032,
-0.024307016,
0.0049996036,
0.003107816,
-0.0035261433,
-0.01602854,
0.0043323124,
-0.0230876,
-0.023561817,
-0.032842923,
0.01947,
0.017640878,
0.013149364,
-0.013508414,
-0.015906598,
0.012519333,
0.024266368,
0.0023202768,
-0.02755879,
-0.013250981,
0.018237036,
0.013264531,
-0.020296494,
-0.64732,
-0.0136574535,
0.014050377,
-0.008210731,
-0.010236315,
0.03563403,
0.012593852,
0.019957768,
-0.026447767,
0.016516306,
-0.015283341,
0.017789917,
0.02541804,
-0.016218226,
-0.021488812,
-0.029238874,
0.006561133,
-0.0127835395,
0.020282945,
0.016705992,
-0.029238874,
0.017098915,
0.0011694534,
0.02640712,
0.0052976827,
0.009470793,
0.020418435,
-0.0017867824,
0.004315376,
0.017071817,
-0.0209062,
0.00959951,
-0.007682318,
0.0050131525,
0.052353572,
-0.014971713,
-0.0057380274,
0.021041691,
0.0016707686,
0.02438831,
-0.014551692,
-0.0005318007,
0.049128897,
0.005246874,
-0.0180338,
0.021637851,
0.015757559,
0.016855031,
0.021759793,
-0.0066492017,
-0.0025319809,
0.010663111,
-0.008800115,
-0.02685424,
0.024591547,
-0.003841159,
0.043384094,
-0.013040971,
0.013515188,
-0.004305214,
-0.020757161,
0.0037327663,
0.014565241,
-0.035769522,
-0.011286368,
-0.025282549,
-0.006893085,
0.0153917335,
-0.0049962164,
0.0078110336,
-0.00034571276,
0.041324638,
0.018643508,
0.013928435,
0.031704802,
0.026515514,
0.004024071,
0.001438741,
-0.010134698,
0.018806096,
-0.01789831,
0.0018426724,
-0.003891968,
0.0131425895,
0.03593211,
-0.0150801055,
-0.014185867,
0.03446881,
-0.012817412,
0.005473821,
0.012438038,
-0.00032687112,
-0.0077703865,
-0.02394119,
-0.012505784,
0.027775576,
-0.0317861,
0.006219019,
0.028046556,
-0.008718821,
-0.01442975,
-0.024889626,
-0.00418666,
-0.01428071,
0.0147820255,
0.02757234,
-0.029645346,
0.02077071,
0.047448814,
-0.019971317,
-0.020730063,
-0.004989442,
-0.018602861,
-0.014565241,
0.026366472,
-0.032734532,
-0.0075807,
0.009653706,
0.004024071,
-0.018128645,
0.011821556,
0.010039855,
0.011665742,
-0.0041121403,
-0.017667975,
-0.008529134,
-0.015649166,
-0.015486577,
0.017586682,
-0.016638247,
0.0001794192,
0.0014709199,
0.0033415372,
-0.017884761,
0.01602854,
-0.0055381786,
0.020161003,
-0.00011093294,
-0.012526107,
-0.014416201,
-0.04010522,
-0.017247954,
0.014836222,
0.0018274296,
0.00865785,
0.0038784188,
0.012316097,
-0.00980952,
0.0120180175,
-0.026163237,
0.037639294,
-0.0028639329,
-0.029699542,
0.01501236,
-0.009396274,
-0.001180462,
-0.0019713885,
-0.035877913,
0.018345429,
-0.018399626,
0.02265403,
0.003739541,
-0.012343194,
-0.01646211,
-0.013332277,
-0.003346618,
-0.006408706,
0.0005309538,
-0.015757559,
-0.018277684,
0.01976808,
-0.016367266,
-0.024225721,
0.020025512,
0.005849807,
0.00047082987,
-0.0021272027,
-0.017952505,
0.008603654,
-0.011631869,
0.004098591,
-0.0036751828,
-0.020350689,
-0.01589305,
0.027911067,
-0.0027182803,
0.0064832256,
0.010107599,
-0.0070251883,
0.03942777,
-0.019415805,
0.009850168,
-0.013982631,
0.029780837,
-0.0153917335,
-0.004664264,
-0.003766639,
0.0088475365,
0.00054069224,
0.011645418,
0.017681524,
-0.026393572,
0.024130877,
0.007099708,
0.027463946,
-0.021272026,
0.012769991,
-0.001212641,
0.018074447,
0.024008937,
-0.0035905011,
-0.019348059,
-0.012688695,
-0.0018087997,
0.0070455116,
0.018724803,
-0.0013438975,
-0.008468163,
-0.0076958667,
0.0023914094,
-0.0008108266,
0.010568268,
0.027883967,
0.0057888366,
-0.029211776,
0.010134698,
0.009308205,
0.006449353,
0.0055618896,
-0.02265403,
-0.011713163,
0.0014472092,
-0.0038208351,
0.0022999533,
0.012675147,
0.0059819105,
0.009098195,
0.001180462,
0.0013608339,
0.006588231,
-0.009626608,
0.0027589276,
0.004098591,
0.010690209,
0.003891968,
-0.021678498,
0.009674029,
0.0036548593,
-0.02020165,
0.025052214,
0.027748477,
0.007038737,
-0.024876077,
-0.0039935857,
0.0108257,
0.0007718731,
-0.0032399192,
-0.016231775,
0.016678894,
0.03143382,
0.03002472,
0.008813664,
-0.0019883248,
-0.014334907,
-0.007993946,
-0.0069134086,
-0.021583654,
-0.022897914,
-0.014389103,
-0.028615618,
-0.020960398,
-0.004789593,
0.011550575,
-0.011753811,
-0.009457245,
0.020879103,
0.0039766496,
0.0034922706,
0.03406234,
0.0019036431,
-0.026163237,
-0.015838852,
0.034604304,
0.03333069,
-0.014619437,
-0.022206912,
0.009037224,
0.0140639255,
-0.013135815,
-0.0043221507,
0.02513351,
0.0071810023,
0.023331484,
-0.0151884975,
-0.002845303,
0.000100612364,
0.024456056,
-0.025336744,
-0.0036616337,
-0.002946921,
0.007120032,
-0.015053007,
-0.02757234,
-0.013129041,
0.028371735,
0.02078426,
-0.014605888,
-0.002996036,
0.0047523333,
-0.010358257,
-0.0008290332,
0.0030587006,
0.0003626491,
0.010080501,
-0.0065408093,
0.00068211055,
-0.007479082,
-0.0026437605,
0.015107203,
-0.019158373,
-0.0042679543,
-0.048668228,
-0.026339374,
0.022355951,
0.024469605,
0.03262614,
-0.017139563,
-0.0028893373,
0.01262095,
0.007905877,
-0.002784332,
-0.027477495,
0.013217109,
0.0070251883,
-0.018724803,
-0.018968686,
0.005209614,
-0.0034651724,
-0.0014234983,
0.02552643,
-0.012458362,
-0.027233614,
-0.0026962631,
0.019510647,
0.002061151,
-0.0016699218,
0.034333322,
0.045091275,
0.014172318,
-0.017857663,
0.0054602716,
0.031108644,
0.005948038,
-0.016827933,
-0.02367021,
0.017789917,
0.003439768,
0.022193363,
-0.018508017,
-0.003942777,
0.01818284,
-0.021678498,
0.0041324636,
-0.011604771,
0.020702966,
0.0013820042,
0.004786206,
0.011381212,
0.015500126,
-0.015256243,
0.012329645,
0.021177182,
-0.014524594,
-0.030485388,
0.019551296,
-0.02685424,
0.016827933,
-0.017979605,
0.012268675,
-0.02150236,
-0.016624698,
-0.018142194,
0.01125927,
-0.005270585,
-0.011367663,
-0.019998414,
0.011401535,
0.0011034016,
-0.009931462,
-0.018060898,
-0.03360167,
-0.0108257,
-0.027721379,
-0.010121149,
-0.0058565815,
-0.015134301,
-0.00793975,
-0.019930668,
0.0036988938,
0.026461316,
0.0067508197,
-0.0054602716,
0.011347339,
0.027220065,
-0.013122266,
0.007086159,
0.0023304385,
-0.021732694,
0.014890418,
0.008840762,
0.0031637058,
0.0040681055,
-0.010087276,
0.014131671,
-0.024334114,
-0.012065439,
0.0074248854,
0.0030671686,
0.00426118,
0.0069777668,
-0.0029282907,
0.017234406,
-0.026745846,
-0.016082736,
-0.01846737,
-0.01414522,
-0.01688213,
-0.009945011,
0.0037632517,
-0.024307016,
-0.015405282,
-0.018006703,
0.010371806,
-0.022477893,
0.011177976,
-0.008068466,
0.0077703865,
-0.0016064106,
0.0230876,
0.021285575,
-0.01831833,
0.006534035,
0.018833196,
-0.012458362,
0.0027453785,
-0.019822277,
0.028913697,
-0.0026776332,
-0.029130481,
0.010832475,
0.0052536484,
-0.020242298,
-0.018128645,
-0.014009729,
-0.022572735,
0.038235452,
0.0020831681,
0.013122266,
0.009443696,
0.0079736225,
-0.00049496413,
0.02713877,
-0.0067067854,
-0.0033178264,
0.017207308,
-0.00980952,
-0.014199416,
-0.0042577926,
0.0012736118,
-0.03853353,
-0.008508811,
0.005927714,
-0.004687975,
0.043682173,
0.008197182,
-0.007932975,
-0.009484343,
-0.016936326,
-0.011150877,
-0.034821086,
-0.004061331,
-0.004711686,
0.020919751,
0.032978415,
0.027911067,
0.0061343373,
0.009423372,
0.017288603,
0.008007495,
-0.0050368635,
-0.010710533,
0.030295702,
-0.005172354,
-0.021908833,
0.015242694,
0.0022897914,
0.011015386,
-0.019456452,
0.008529134,
0.011150877,
-0.023128247,
-0.02150236,
0.007824583,
-0.050538,
-0.002181399,
0.00019339168,
0.009308205,
0.033547476,
-0.026217433,
0.010486973,
0.027883967,
-0.0069777668,
0.012478685,
0.016489208,
0.024347663,
-0.020743612,
0.051892903,
0.004288278,
0.020133905,
0.0158795,
-0.010473425,
-0.0014294259,
-0.0037768008,
0.013305178,
0.0016394363,
0.02945566,
0.016272422,
-0.0259871,
0.014158769,
0.010967965,
-0.022721775,
-0.0060835285,
-0.0038885805,
-0.013555836,
-0.022925012,
-0.010304061,
-0.003549854,
-0.012194155,
-0.00699809,
-0.0004054133,
-0.017803466,
0.0055381786,
0.006550971,
-0.019673238,
-0.0209062,
0.009389499,
0.051649023,
-0.004328925,
0.0033330692,
0.023331484,
-0.010121149,
-0.04010522,
0.018955136,
0.016787287,
-0.0044711903,
0.029347267,
0.03549854,
-0.012553205,
-0.0027606213,
0.019971317,
-0.0067271087,
-0.023060502,
-0.024645742,
-0.011570898,
0.009585961,
0.008712047,
-0.0047184606,
-0.008725596,
-0.0068084034,
0.010209218,
-0.031000253,
0.0063883825,
-0.02280307,
-0.007858455,
-0.0005385752,
0.023832798,
-0.029184679,
0.019104177,
0.00046828942,
-0.00627999,
0.0069134086,
-0.02988923,
-0.026054844,
0.0065441965,
0.004342474,
0.03734121,
-0.016678894,
0.019158373,
-0.0040782676,
-0.018575763,
-0.0038885805,
-0.02064877,
-0.021841086,
0.043221503,
-0.013169687,
-0.015025909,
-0.007174228,
0.0148768695,
0.015920147,
0.011035711,
-0.0011211848,
-0.009355627,
-0.009104969,
-0.026014198,
0.02942856,
0.0004725235,
0.0071268063,
0.0046744263,
-0.025065763,
-0.012126409,
-0.023426326,
-0.03392685,
0.01218738,
-0.041216243,
0.01975453,
-0.009023675,
0.0022931786,
0.009348853,
-0.003107816,
0.013271306,
-0.03579662,
0.004122302,
-0.028019458,
0.027152319,
0.011814781,
-0.004200209,
-0.010940867,
0.020581024,
-0.022464344,
-0.021597203,
0.015066556,
-0.0041087526,
-0.0012998631,
-0.034224927,
0.0035295305,
-0.00061944616,
0.0072351987,
-0.023412777,
0.0050571873,
0.008935606,
0.02755879,
-0.020174552,
-0.016489208,
0.03148802,
-0.014443299,
0.0046303915,
0.0135016395,
0.013474542,
0.014091023,
0.0059446506,
-0.006215632,
-0.019307412,
-0.01615048,
-0.02537739,
-0.007560376,
0.032788727,
0.014104573,
0.02727426,
-0.0127361175,
-0.011625094,
0.0061648227,
0.007160679,
0.010846023,
-0.021448163,
-0.0051350943,
-0.002877482,
0.0013252676,
0.048993405,
-0.0066254907,
-0.030160211,
-0.010649562,
-0.008454614,
-0.05322071,
-0.020757161,
-0.028696911,
0.036988936,
0.025905805,
-0.012966451,
-0.009667255,
0.006066592,
-0.014646535,
-0.0076281214,
-0.0063680587,
0.0067880796,
0.008495261,
0.024727037,
0.0066221035,
0.032436453,
-0.028480127,
0.015025909,
-0.02498447,
-0.025960002,
-0.0018867068,
-0.0021610754,
0.031108644,
0.0050199274,
-0.03522756,
-0.0153917335,
0.025892256,
-0.002028972,
-0.021177182,
0.021895284,
0.013332277,
0.019781629,
-0.01054117,
-0.0148768695,
-0.0054941443,
-0.00422392,
0.007838132,
-0.0088949585,
0.006916796,
-0.008407192,
-0.00937595,
0.006893085,
-0.009585961,
0.009802746,
-0.0123770675,
0.020147454,
-0.015093654,
-0.025160607,
0.0148768695,
-0.012600627,
0.0014895499,
0.023074051,
0.021312673,
-0.021163633,
0.01846737,
-0.014687182,
-0.007953299,
0.0026759396,
0.0073097185,
0.01573046,
0.006679687,
-0.025770314,
-0.009247234,
-0.017803466,
-0.009558863,
-0.0075129545,
0.002631905,
-0.00011135635,
-0.0067982413,
-0.024130877,
0.018792547,
0.027220065,
0.0007316493,
-0.015676264,
-0.009138842,
-0.018711254,
0.010575042,
-0.00080193504,
0.027965263,
-0.007560376,
-0.013169687,
-0.0041798856,
-0.028344637,
0.00016354141,
0.004383121,
-0.034279127,
-0.02222046,
-0.0050368635,
0.19109596,
-0.016922778,
0.016868582,
-0.009362401,
0.009978884,
-0.030376995,
0.0108257,
0.016570501,
0.0054162373,
0.026339374,
0.0016580664,
-0.0063816076,
0.015500126,
0.0070319627,
0.026772944,
-0.04230017,
-0.033818457,
-0.028507225,
0.0017410544,
0.009748549,
0.034306224,
-0.030702172,
0.01499881,
-0.0187519,
0.030268602,
-0.0076281214,
-0.020608122,
0.008325898,
0.019415805,
0.010608915,
-0.017532485,
0.008109113,
0.007011639,
0.019862924,
-0.020323591,
0.009159165,
0.017938957,
-0.030160211,
0.02007971,
-0.016773738,
-0.00880689,
0.0069066337,
-0.034035243,
0.0018325106,
-0.009775648,
0.015622067,
0.008576556,
-0.014524594,
0.0051249326,
-0.0021661562,
-0.029970523,
-0.004928471,
-0.021136535,
0.03249065,
-0.011320241,
-0.012499009,
0.03950906,
-0.0012507477,
0.00959951,
0.03219257,
0.00422392,
0.009701128,
-0.0129393535,
0.02337213,
-0.006574682,
0.01831833,
-0.015053007,
-0.016868582,
-0.013630356,
-0.008359771,
0.02049973,
-0.048017874,
0.0013151057,
0.017654426,
-0.0058836797,
0.0039258404,
0.03666376,
-0.008901733,
0.01615048,
0.020147454,
-0.011482829,
0.010290512,
-0.012756441,
0.008752693,
-0.02627163,
-0.033439085,
0.0418937,
0.0023947966,
-0.02064877,
0.0046812007,
-0.00092472346,
-0.0020713126,
-0.015554322,
-0.013339051,
-0.003942777,
-0.0046371664,
-0.00016100095,
0.0014184173,
0.009823069,
-0.013223884,
-0.026732298,
0.056960255,
-0.011211848,
0.010358257,
-0.027667183,
-0.0044339304,
-0.01804735,
0.0062257936,
0.014172318,
0.017993154,
0.024550898,
-0.025756765,
0.004847177,
-0.010913769,
-0.019009333,
0.049101796,
0.010005982,
-0.033303592,
0.02150236,
-0.008136211,
0.011638643,
-0.02899499,
0.008637526,
0.019564845,
-0.011564123,
-0.00004551638,
-0.008684948,
0.0023016469,
-0.00057371805,
-0.030160211,
-0.00952499,
-0.004227307,
0.012946128,
0.024577998,
0.0013625275,
-0.004034233,
0.00200018,
-0.012302548,
-0.029157579,
-0.0050131525,
-0.008630752,
-0.014321358,
-0.014660085,
-0.0005068196,
-0.0014074087,
-0.020242298,
0.021312673,
0.015771108,
-0.03595921,
-0.0072216494,
-0.014131671,
-0.021637851,
-0.0070251883,
-0.015486577,
0.0015369717,
-0.016990522,
-0.020404886,
-0.021421066,
0.0010475118,
0.010595365,
-0.010554719,
0.030783467,
0.00980952,
0.003089186,
0.0032348384,
0.012851285,
-0.17212728,
0.009626608,
0.00873237,
-0.025648372,
0.022599835,
-0.008820439,
-0.005873518,
0.011821556,
0.009416598,
-0.00048480235,
0.035417248,
0.0062867645,
-0.026339374,
0.0020950236,
-0.0027978811,
0.009945011,
-0.041839503,
0.007892328,
0.0062257936,
0.00331952,
0.016082736,
-0.01990357,
0.009985658,
-0.02555353,
0.009911139,
0.023846347,
0.007201326,
0.009443696,
-0.015066556,
-0.027043926,
-0.0077432883,
0.015242694,
0.033818457,
-0.007519729,
-0.020526828,
-0.008366546,
-0.010785053,
0.0059954594,
0.0033398436,
0.0007269918,
0.020377789,
0.027721379,
0.024781233,
-0.00085232063,
-0.02280307,
0.04197499,
-0.0014412814,
-0.025567079,
0.026447767,
-0.005754964,
-0.0053146193,
0.009558863,
0.030837663,
0.0014446686,
0.019957768,
0.0024794783,
0.010906994,
0.012817412,
-0.006777918,
0.013244207,
0.007831357,
-0.02785687,
0.013454217,
-0.0131425895,
0.0049725054,
-0.02251854,
-0.012038341,
0.003139995,
-0.033249397,
-0.0031366076,
-0.005426399,
0.009274333,
0.024577998,
-0.018426724,
0.020459082,
-0.0035701776,
-0.008210731,
0.0017732334,
0.030864762,
-0.04571453,
-0.033547476,
-0.013982631,
-0.017667975,
-0.0053823646,
-0.0028876436,
-0.01628597,
-0.01529689,
0.008752693,
-0.009335303,
0.003148463,
0.026312277,
-0.006178372,
0.002623437,
-0.015825303,
-0.011320241,
0.0045016757,
-0.0027606213,
0.007560376,
0.01746474,
0.010290512,
0.0031332204,
-0.03362877,
-0.026312277,
0.009836619,
0.033276495,
-0.008136211,
-0.01661115,
0.021556556,
0.024727037,
-0.003702281,
0.0011609852,
0.021163633,
0.011516702,
0.02106879,
0.0076890923,
0.021841086,
-0.020296494,
-0.0062766024,
0.0011313466,
-0.0027199741,
0.045795828,
-0.0030722497,
0.011713163,
-0.007872005,
0.004366185,
-0.00033533925,
-0.12497654,
-0.009186263,
0.0065950057,
0.010534395,
0.0039393897,
0.016651796,
-0.007682318,
-0.005914165,
-0.014524594,
0.03492948,
-0.028263342,
-0.009985658,
-0.028507225,
-0.016678894,
0.018358978,
0.0069506685,
0.009836619,
-0.011401535,
-0.03148802,
0.02945566,
-0.0034109761,
-0.0059581995,
0.0010110987,
-0.003204353,
-0.013969082,
-0.0059581995,
-0.032707434,
0.030783467,
0.0010077114,
0.028480127,
-0.00025595023,
-0.0054399483,
-0.007885554,
-0.009389499,
-0.035444345,
-0.007682318,
-0.0041121403,
-0.03652827,
0.031135743,
0.011225397,
-0.0002949038,
0.0018613023,
0.013820043,
-0.0018308169,
0.018223487,
0.010385355,
-0.024347663,
0.0034888834,
0.0062630535,
-0.02007971,
-0.0015547548,
-0.022017224,
-0.015459479,
-0.0019561457,
0.0019375158,
-0.016624698,
-0.0075400528,
-0.00036116716,
-0.009308205,
-0.004606681,
0.021854635,
-0.004318763,
-0.013745522,
0.0069642174,
0.010053404,
-0.0065204855,
-0.030864762,
-0.032734532,
-0.005223163,
-0.021895284,
-0.0063375733,
0.0011211848,
0.010480199,
-0.016963424,
-0.015337537,
0.018345429,
-0.02785687,
-0.015242694,
0.029970523,
-0.033466183,
-0.009633383,
-0.017234406,
0.011611545,
-0.009186263,
0.019727433,
-0.001825736,
0.0014768477,
-0.0036853447,
0.0024676227,
-0.017437642,
-0.013718424,
0.036338583,
0.014009729,
0.004342474,
-0.029265972,
0.001369302,
-0.004176498,
-0.010812151,
0.019090626,
0.02640712,
-0.018629959,
-0.017356347,
-0.056635074,
0.01399618,
0.0029096608,
-0.019971317,
-0.0006744892,
-0.011482829,
0.02972664,
-0.0020374402,
0.012417715,
0.016272422,
-0.014768477,
0.028507225,
-0.014822673,
0.0046676514,
-0.001710569,
-0.039183885,
0.04601261,
0.006754207,
0.023358582,
0.033710063,
0.0066830744,
0.007099708,
0.01254643,
0.036880545,
-0.0053417175,
0.0063409605,
-0.012404165,
0.032707434,
0.007838132,
-0.014402652,
0.015771108,
-0.0012837736,
-0.017938957,
0.01774927,
0.009423372,
-0.022599835,
0.012573529,
0.023439877,
0.024171526,
0.021881733,
0.004596519,
-0.018738352,
-0.02310115,
0.015418831,
-0.013840366,
-0.00032327214,
-0.030973153,
0.02151591,
0.0059649744,
-0.00743166,
0.04341119,
0.0004945407,
0.018006703,
-0.027165867,
-0.018724803,
-0.0037971244,
0.02988923,
-0.0039089043,
-0.00070285756,
-0.02266758,
0.033086807,
-0.017261503,
0.015540773,
0.00494202,
-0.019998414,
-0.028886598,
-0.0068659866,
-0.008278476,
-0.0032941154,
-0.021556556,
-0.019876473,
0.011753811,
-0.009457245,
0.008258153,
0.007851681,
-0.005467046,
-0.0032399192,
0.032219667,
0.003729379,
0.014158769,
0.0037768008,
0.021407517,
-0.0009712983,
0.028263342,
0.010148247,
0.005758351,
0.004660877,
0.014660085,
0.015540773,
0.018440273,
0.0025268998,
0.013108716,
-0.0020035675,
0.013237433,
0.0013642211,
0.023155347,
0.0041155275,
-0.0037327663,
0.01025664,
0.014836222,
-0.008664625,
0.001221956,
-0.009179489,
-0.023602465,
-0.0017232712,
0.01948355,
-0.03807286,
-0.03620309,
-0.012519333,
0.01291903,
0.018277684,
-0.0031704803,
-0.0034363805,
-0.008305575,
-0.0030671686,
-0.004762495,
-0.01574401,
0.0058396454,
-0.014646535,
0.022694677,
0.002061151,
0.007607798,
0.022586284,
-0.019537747,
-0.013799719,
0.004542323,
0.022396598,
-0.016692443,
0.034821086,
-0.008434291,
0.026339374,
0.011049259,
-0.00093319156,
-0.009233685,
0.0027419913,
-0.022396598,
0.009084646,
0.010568268,
-0.031108644,
0.07695867,
0.014402652,
-0.0066221035,
0.013677778,
0.0042713415,
0.02077071,
0.0071471296,
-0.00093149795,
-0.003637923,
-0.03376426,
-0.018209938,
-0.016380815,
0.024713488,
-0.010663111,
-0.021448163,
0.016638247,
0.012390616,
-0.005080898,
-0.030973153,
-0.042598248,
-0.0043763467,
-0.017220857,
0.0062088575,
0.0075874743,
-0.009626608,
-0.012329645,
0.016367266,
0.010398905,
-0.010053404,
-0.009701128,
0.006296926,
0.0032450003,
-0.039861336,
-0.02265403,
-0.013447443,
-0.022423696,
0.0075942487,
0.011279593,
0.022992756,
-0.013610032,
-0.0068253395,
0.014362005,
-0.010304061,
0.009355627,
-0.013779395,
-0.05387107,
-0.0020814745,
-0.03799157,
-0.028182046
] |
Electro-magnetic fields and wireless technology are part of modern life. The use of Magnetic Resonance Imaging (MRI) machines for clarification of internal human structures and function in healthcare is increasing. The rapid development of wireless devices, their miniaturization and their application as clinical tools creates an expanding intersection zone. Although safety standards for devices in MRI machines have been previously published, it is not clear that newer wireless technologies, including devices used in Medical Body Area Networks (MBAN) have been rigorously tested or disclosed. We undertook a review of the clinical scientific literature and the United States Food and Drug Administration adverse events database to discover whether | [
-0.012281883,
-0.011339639,
0.024040297,
-0.02219507,
-0.0116275465,
-0.0061998316,
-0.019433772,
-0.016384568,
-0.023843996,
-0.012079039,
-0.0062227333,
0.02024515,
0.010155291,
0.0077735092,
-0.0028185514,
0.008283891,
0.031015515,
0.013950439,
-0.008427844,
-0.0138588315,
-0.023242006,
0.013741052,
-0.023255093,
-0.0016031227,
0.0038213208,
0.030806128,
0.021697775,
-0.03431337,
-0.02155382,
-0.003831136,
0.021710861,
0.012635224,
-0.020677011,
-0.0329,
-0.019093517,
0.0016137556,
0.017941887,
-0.012151015,
0.0036642803,
-0.009657996,
0.011660264,
0.002852904,
0.0030001295,
0.013597097,
-0.007236954,
0.015520845,
0.007838943,
-0.021449126,
-0.008748469,
0.025623789,
0.014761815,
0.0020120826,
-0.01983946,
-0.007950179,
-0.022901753,
-0.01521985,
-0.017431505,
0.041772798,
0.016306048,
-0.028136438,
-0.0038049626,
-0.0003504786,
-0.014068219,
0.000039311268,
0.0037984191,
-0.002627158,
0.010626413,
0.033423472,
-0.0015965793,
-0.015115157,
0.021213565,
0.008768099,
0.0017274464,
0.017915713,
0.018674742,
-0.005967542,
0.010331962,
-0.0056305593,
0.0145393405,
-0.0053426516,
0.012098668,
-0.014172913,
0.010914321,
0.007910919,
0.022941012,
0.009383175,
-0.002568268,
0.0049664085,
0.013570924,
0.0078585725,
0.0015957614,
0.034234848,
-0.004066697,
0.0028300022,
0.010515176,
0.01613592,
-0.010037511,
0.025047973,
0.012700657,
-0.006297982,
-0.011810761,
0.01669865,
-0.013440057,
-0.015730232,
-0.026435165,
0.0018076026,
-0.0042728125,
-0.010646043,
0.036799844,
-0.03454893,
-0.011823848,
0.033266433,
0.009003661,
0.0044494835,
-0.006785462,
-0.008571799,
0.011444333,
-0.021946423,
0.026644552,
-0.001915568,
0.011817304,
-0.011751871,
0.01521985,
-0.019224385,
0.017392244,
0.0043578763,
-0.043814324,
0.022378284,
0.011601374,
-0.010331962,
-0.010011338,
-0.030413527,
0.009402805,
0.01662013,
0.012196819,
0.0088924235,
0.00039648658,
-0.0033240258,
-0.013937352,
-0.017169772,
0.020690097,
0.017352985,
-0.021815555,
-0.02307188,
-0.014251433,
0.019342165,
0.012366946,
0.023765475,
0.015128243,
-0.0021544006,
-0.020847138,
-0.038160864,
-0.009599105,
0.0035399566,
-0.0216716,
0.006010074,
-0.037087753,
0.031748373,
-0.025296621,
-0.024210423,
0.0017601632,
0.0026026205,
-0.005990444,
0.029026335,
-0.001456715,
0.030387353,
-0.013570924,
-0.0036348351,
0.0067658317,
0.009193418,
-0.0056567327,
0.022600757,
-0.015900359,
0.0031195458,
-0.01169298,
0.0030704706,
-0.011025558,
0.025047973,
-0.032245666,
-0.02051997,
0.00535901,
-0.008683036,
0.030256486,
0.010901234,
-0.017339898,
0.023438308,
0.018478442,
-0.018360661,
0.016201355,
-0.03143429,
0.020991093,
0.013780312,
-0.0007860208,
-0.011280749,
-0.6407256,
0.0049958536,
0.026225777,
-0.0037722457,
0.006844352,
0.01529837,
0.02582009,
-0.005051472,
0.016005052,
0.030256486,
-0.01079654,
0.017300637,
0.0099262735,
-0.02211655,
-0.014460821,
-0.0116144605,
-0.006049334,
-0.01976094,
0.01995724,
0.008617602,
-0.021998769,
0.026906287,
-0.018347574,
0.0037951474,
-0.021422952,
-0.011745327,
0.007001393,
0.014172913,
-0.006124583,
0.020048847,
-0.028424347,
0.027508276,
0.013780312,
0.02761297,
0.042217743,
-0.010397395,
-0.008683036,
0.039600402,
0.009972077,
0.0008097405,
0.01149668,
-0.029942404,
0.008231544,
-0.0072762137,
-0.021095786,
0.035752907,
0.010135661,
-0.0033796444,
-0.0033354766,
-0.016070487,
-0.008290434,
0.008931683,
-0.024694633,
0.037715916,
0.01165372,
0.013989699,
0.020389102,
-0.008205371,
0.0107703665,
0.011503223,
0.008761556,
0.011908911,
-0.013806485,
-0.0304397,
-0.011123708,
0.015651712,
-0.018138187,
0.010259985,
0.00816611,
0.021056525,
0.027141849,
0.030335007,
0.0023277996,
-0.0023932331,
0.014945029,
0.04132785,
0.0032046095,
-0.00047562033,
-0.009311198,
0.00179288,
0.011745327,
-0.0036086617,
-0.019237472,
-0.010299245,
0.0160574,
-0.013125976,
-0.0011180963,
0.011699524,
0.03151281,
-0.026029477,
0.005898837,
0.009729973,
-0.024158077,
-0.03242888,
-0.011823848,
-0.011326552,
0.0031228175,
0.004298986,
0.02032367,
0.00058849325,
-0.028162612,
-0.0011581744,
0.008427844,
-0.015115157,
-0.021187393,
0.010286158,
-0.009245764,
0.0045836223,
0.029706845,
-0.028973987,
-0.011130252,
0.0060198894,
0.006520456,
0.0053132065,
0.0021135046,
-0.021331346,
-0.004115772,
0.010246898,
-0.020585403,
-0.020061934,
0.025047973,
-0.023974862,
0.0058039585,
-0.022574585,
-0.0009553302,
0.000489116,
0.01060024,
-0.0034418062,
-0.0021429497,
0.0014951573,
-0.0050318423,
-0.0077407924,
-0.0024619384,
-0.001925383,
-0.0007275396,
0.018360661,
0.0074332543,
-0.0067527452,
0.009271938,
-0.0118042175,
-0.01173224,
-0.0152329365,
0.014513168,
0.0122949695,
-0.010181464,
-0.015416151,
-0.015115157,
0.019355252,
-0.0017781574,
-0.009468239,
-0.016528523,
-0.00707337,
-0.01701273,
0.02441981,
0.028476693,
-0.005581484,
-0.010927407,
-0.025479835,
-0.026081825,
-0.00032532756,
-0.01173224,
0.029235722,
-0.0080287,
0.0019041171,
0.0016898222,
-0.026513686,
0.007714619,
0.00046212465,
0.009448608,
-0.02821496,
0.013911178,
-0.0012505993,
-0.011607917,
0.012877328,
-0.019577727,
0.024498332,
-0.0016513799,
-0.019158952,
-0.019329078,
-0.008859706,
-0.013040912,
0.0030279388,
0.006949046,
-0.0050645587,
0.033920765,
0.008473649,
0.034836836,
-0.02829348,
-0.03240271,
0.011457419,
-0.0075575784,
0.038160864,
-0.014814162,
-0.0006764196,
-0.0010673852,
-0.005817045,
-0.01757546,
-0.0078324,
0.0047144894,
0.009638366,
0.018949565,
0.0072893007,
0.032324187,
0.011365812,
0.022168895,
-0.027743837,
0.009350458,
-0.01948612,
0.020506883,
0.009108354,
-0.009887014,
-0.017195944,
0.012609051,
-0.022587672,
-0.0037526158,
0.011208772,
-0.010305788,
0.011889281,
-0.0010624777,
0.009481326,
0.01617518,
0.009245764,
0.03334495,
0.0022934468,
-0.009062551,
0.0064942827,
0.000097536926,
0.0111106215,
-0.006095138,
-0.01268757,
-0.004861715,
0.02852904,
0.019067345,
0.013675618,
0.0020644295,
0.004125587,
-0.015965793,
-0.00991973,
0.03693071,
0.0062031033,
0.025335882,
0.027639143,
0.009396262,
-0.0021740305,
0.043369375,
-0.00013863739,
0.02287558,
0.0008375498,
-0.00666441,
-0.01737916,
-0.016436914,
0.003047569,
-0.025283534,
0.034836836,
0.026265038,
-0.023791648,
0.031067863,
-0.025885524,
0.02231285,
0.0016930938,
0.029392764,
0.017915713,
0.012890415,
-0.0047046742,
-0.014212173,
0.01757546,
0.014395387,
-0.010371222,
-0.010508632,
0.01434304,
-0.004083055,
-0.028581386,
0.012916588,
-0.022770885,
0.028084092,
0.027691491,
0.022770885,
0.014055133,
0.027403582,
0.030230314,
-0.022731625,
-0.029654497,
0.0106067825,
0.018151274,
-0.005849762,
-0.027665317,
-0.025309708,
-0.012281883,
-0.021121958,
-0.009710343,
0.0055487673,
0.011005928,
-0.0047210325,
0.009239221,
-0.0029903145,
0.003595575,
0.013701791,
0.013701791,
-0.0069032423,
0.0050612874,
-0.006265265,
0.006356872,
0.0025093777,
-0.012085582,
0.020088108,
-0.0008068778,
0.0061507565,
-0.01067876,
0.007995984,
-0.0196039,
-0.00908218,
-0.020755531,
0.011038644,
0.009834667,
-0.014918855,
0.043081466,
-0.01669865,
0.0066055194,
0.0022983544,
-0.0087157525,
-0.005035114,
-0.0138588315,
-0.0020137182,
-0.00584649,
0.06391552,
0.0054473453,
-0.0022018398,
0.012968935,
0.0036086617,
-0.01964316,
-0.030335007,
-0.013453144,
0.0073285606,
-0.00086454116,
0.0029281527,
0.014447734,
0.012844611,
0.016463088,
0.0076360987,
0.013243756,
0.010161835,
-0.011084448,
-0.02753445,
-0.015808752,
0.023058793,
-0.009729973,
0.01645,
0.029157203,
0.029235722,
-0.017457679,
0.002800557,
0.025715396,
0.0055749407,
-0.030020926,
0.019302905,
0.027429756,
0.0016333857,
0.0048551713,
-0.019276733,
0.017431505,
0.013027825,
-0.007629555,
0.0027285803,
-0.0047995527,
0.028450519,
0.035962295,
0.008231544,
-0.0041844775,
-0.0022492793,
-0.025702309,
-0.003199702,
0.010397395,
0.0063503287,
-0.0016800071,
0.0265006,
-0.019211298,
-0.00018372522,
-0.03454893,
0.025047973,
0.002823459,
-0.0057287095,
-0.004289171,
-0.01765398,
0.0044658417,
-0.0069621326,
0.00584649,
0.034051634,
-0.0057090796,
-0.022181982,
-0.017811019,
-0.02944511,
-0.0065564443,
-0.011568656,
-0.008264261,
-0.0040699686,
-0.011221859,
-0.019315992,
0.017366072,
0.043604936,
0.0046719573,
0.028319653,
0.003657737,
0.00009927501,
0.04195601,
-0.002496291,
0.00039423732,
0.008454018,
-0.017876454,
-0.0036152052,
0.015965793,
0.000794609,
-0.019224385,
-0.014513168,
0.0046817726,
0.006317612,
-0.011522853,
0.016515436,
0.0050187553,
-0.009893557,
0.021148132,
-0.00882699,
-0.0036021185,
-0.007714619,
-0.012144472,
0.0054637035,
-0.009363545,
-0.01892339,
-0.014015872,
0.01521985,
-0.002048071,
-0.005568397,
0.00027134488,
0.013688704,
0.018033493,
-0.016279874,
-0.0072173234,
0.019407598,
0.00093242846,
0.020847138,
0.021121958,
0.017994234,
0.018570049,
-0.010979754,
0.01253053,
-0.0034614364,
-0.03648576,
0.019983415,
-0.0046686856,
-0.00705374,
0.01054135,
-0.013381166,
0.013898092,
-0.022927925,
-0.010364679,
0.008578342,
0.062135726,
0.012713744,
-0.029104855,
-0.026487513,
-0.022064202,
-0.0018255968,
0.011470506,
-0.024589939,
-0.0056730914,
-0.020114282,
0.02621269,
0.019420685,
-0.026186518,
0.016855689,
-0.037663568,
-0.005022027,
0.020650838,
-0.021252826,
0.043212336,
-0.007747336,
0.008310065,
-0.016921123,
-0.013518577,
-0.016345307,
-0.023922516,
-0.0135054905,
-0.022051116,
0.052922677,
0.037794434,
0.035909947,
-0.0007917463,
0.0055454955,
0.01757546,
0.0106067825,
-0.0053230217,
-0.026880113,
0.0023408863,
-0.0054571605,
0.029340416,
0.0012489634,
-0.0007054558,
0.011588287,
0.01578258,
-0.018321402,
0.004279356,
0.009448608,
-0.008355868,
-0.011882737,
-0.02792705,
-0.006258722,
-0.015507758,
-0.01928982,
0.011090991,
-0.03729714,
-0.0016980013,
0.043081466,
-0.0052837613,
0.01872709,
-0.024969453,
0.026042564,
-0.016201355,
0.0041713906,
0.0039063846,
-0.004331703,
-0.022783972,
-0.0056501892,
-0.018570049,
-0.029942404,
0.024459071,
0.03402546,
-0.009703799,
0.0011279113,
-0.008074503,
0.001293131,
0.0037624307,
-0.010174922,
0.015769493,
-0.0104301125,
-0.019459946,
-0.009815036,
-0.009847754,
-0.028947815,
-0.024629198,
0.030020926,
0.02792705,
-0.01167335,
0.036407243,
-0.01765398,
0.0034647079,
0.020179715,
-0.013276473,
-0.0019106604,
0.0011499951,
0.03564821,
0.023451393,
-0.0128380675,
-0.026932461,
-0.022469891,
-0.008859706,
-0.023922516,
0.0155470185,
0.01968242,
-0.02777001,
-0.019865634,
0.023961777,
-0.0033992743,
-0.007662272,
-0.049232222,
0.016436914,
0.006621878,
-0.018622397,
-0.026121084,
-0.015520845,
-0.025885524,
0.00309828,
-0.016476175,
0.00020447993,
-0.020271322,
-0.033318777,
-0.0031718926,
0.009350458,
-0.030779954,
0.023556087,
-0.020847138,
-0.005218328,
0.010377766,
0.0008121943,
-0.000078571415,
0.0021167763,
0.0040503386,
0.029392764,
0.004125587,
-0.014055133,
0.014159827,
0.026984807,
0.00019026858,
-0.021697775,
0.01079654,
0.031355772,
0.017863367,
-0.0021413139,
0.010148748,
-0.02784853,
0.0032684072,
-0.002659875,
-0.017274465,
-0.010960124,
-0.011104078,
0.00046744113,
0.024760066,
0.033842247,
-0.03363286,
-0.027037155,
-0.021213565,
-0.0016800071,
-0.016070487,
0.0014117295,
0.01833449,
-0.032926176,
-0.011843477,
0.026487513,
-0.024498332,
0.016083574,
0.00039260148,
-0.0011884373,
-0.017326811,
0.01919821,
0.00094878685,
0.0058137733,
0.017261378,
0.0025960773,
-0.0054244436,
0.018700916,
0.0031146384,
-0.031355772,
-0.01354475,
0.006458294,
-0.036511935,
-0.017523112,
-0.009697257,
0.009834667,
0.00010116644,
-0.010305788,
0.018622397,
0.0013994606,
0.005368825,
-0.007400538,
-0.022103462,
0.017994234,
-0.012543617,
0.014159827,
0.0053262934,
-0.02578083,
-0.01430378,
-0.018229796,
-0.010220725,
-0.01077691,
-0.017300637,
-0.0074528847,
-0.012962392,
0.03761122,
-0.014918855,
0.0016546516,
-0.00013413884,
0.01358401,
-0.029131029,
0.03020414,
0.009945904,
0.006844352,
0.014081306,
-0.02621269,
0.00012964028,
0.0002617343,
-0.03127725,
-0.008781186,
-0.015900359,
-0.012137929,
-0.022103462,
-0.003677367,
-0.018818697,
0.033554338,
0.01621444,
-0.0015237845,
-0.018714003,
-0.014159827,
-0.050069775,
-0.027743837,
-0.017051991,
0.021566907,
0.013793399,
0.032010105,
0.01249127,
0.010201095,
0.017549286,
0.0067200284,
0.011090991,
0.007282757,
0.01697347,
-0.0020317126,
0.018138187,
0.015834926,
-0.055278286,
-0.016842604,
0.013989699,
-0.01525911,
0.0069948495,
0.04250565,
-0.014552427,
-0.0014787988,
-0.008683036,
-0.00063225196,
-0.016436914,
0.020101195,
0.016855689,
-0.023503741,
0.0052641314,
0.012275339,
-0.01728755,
-0.009965534,
0.010534806,
0.021619255,
0.028581386,
0.006082051,
0.0004136629,
0.011817304,
0.037715916,
-0.015677886,
0.0054866057,
0.008041787,
0.011745327,
0.009507499,
-0.011902368,
-0.019302905,
-0.009579476,
-0.007884746,
-0.013531663,
0.0014084578,
-0.004606524,
-0.020061934,
-0.011234946,
0.010966668,
0.0020856953,
-0.017326811,
0.0104301125,
-0.0050318423,
-0.016384568,
-0.01426452,
-0.003677367,
-0.01788954,
-0.0048748017,
-0.030177966,
0.016149007,
-0.016005052,
-0.0031866152,
-0.030806128,
0.0138457455,
-0.021279,
0.0045214603,
0.009278481,
-0.0066153347,
0.007485601,
0.019787114,
-0.022024943,
0.0074332543,
0.0034679796,
0.1849938,
-0.0055487673,
-0.03219332,
0.010161835,
-0.028267305,
0.0034647079,
0.018700916,
-0.0017814292,
0.005336108,
0.012465097,
-0.0053262934,
0.009559846,
-0.053760227,
-0.006013346,
0.010508632,
0.030047098,
-0.05315824,
-0.007138803,
-0.019028084,
0.036904536,
-0.0053949985,
-0.0028561756,
-0.028057918,
-0.01853079,
0.0035694016,
0.012059408,
-0.005041657,
-0.0011974345,
0.031015515,
0.017496938,
-0.01139853,
-0.012674484,
0.020048847,
-0.0023932331,
-0.032088626,
-0.014473908,
-0.0058922935,
0.007884746,
-0.014329953,
0.0065564443,
-0.014814162,
-0.0010068591,
0.0016742817,
-0.00080319715,
0.010979754,
0.03648576,
0.013754138,
-0.017339898,
0.009448608,
-0.0005766334,
-0.026566032,
-0.008696122,
0.022587672,
0.019420685,
-0.0037133556,
-0.00032471414,
-0.0030230314,
0.0135054905,
0.02239137,
-0.008794273,
-0.01510207,
-0.03036118,
-0.033554338,
0.048499368,
-0.030099446,
0.026709987,
0.013518577,
0.039391015,
-0.0044363965,
0.022836318,
-0.01948612,
-0.0032029736,
-0.029052509,
-0.010305788,
-0.0026647823,
-0.004635969,
0.04732156,
0.00902329,
-0.003168621,
0.0044887434,
0.00080565095,
0.010063685,
-0.024733892,
-0.00036724596,
-0.018700916,
-0.016999643,
0.015128243,
-0.004760293,
0.008218457,
-0.00014630539,
-0.006805092,
-0.0049860384,
-0.0074267113,
-0.008467105,
-0.022325937,
0.011666807,
0.0102534415,
-0.0061867447,
-0.01058061,
0.0011246396,
-0.027246542,
0.06485776,
-0.008251174,
-0.0065499013,
0.0015000647,
0.012111755,
-0.018504616,
0.040725857,
-0.0063634156,
0.0013651081,
0.0074594277,
-0.027796185,
0.007681902,
-0.013662531,
0.0045018303,
0.017784847,
0.004747206,
-0.012818438,
-0.0020284408,
-0.0025731754,
0.019499207,
-0.00446257,
0.00093079265,
0.0064026755,
-0.01073765,
0.0116144605,
0.010135661,
0.0068966993,
0.0050612874,
-0.030020926,
-0.0064550224,
-0.010076771,
-0.00018965514,
-0.008748469,
0.0024406724,
-0.00582686,
0.023359787,
-0.020781705,
-0.006000259,
0.006428849,
-0.005705808,
-0.00978232,
0.018465355,
0.000041151587,
0.011954715,
-0.002088967,
0.013021282,
0.031408116,
-0.019459946,
-0.0062194616,
-0.025427489,
-0.009062551,
0.012792264,
-0.046850443,
0.012229536,
0.001110735,
-0.0014329953,
-0.026094912,
0.0025895338,
-0.007924006,
-0.039338667,
0.0015908539,
0.04271504,
-0.014565514,
-0.006510641,
0.023412134,
-0.16415976,
0.018661655,
0.029418936,
-0.036590457,
0.016646301,
-0.009337371,
0.016868776,
-0.0017176315,
-0.012857698,
-0.024445985,
-0.0045018303,
-0.029418936,
-0.022574585,
-0.012419293,
0.016633216,
0.011974345,
-0.013819572,
0.03991448,
0.009206505,
0.006438664,
0.005368825,
-0.009638366,
0.0158611,
-0.034915358,
-0.010417026,
-0.0018452269,
-0.021108871,
0.010973211,
-0.00056395563,
-0.007845486,
0.0040274365,
-0.021579994,
0.045044474,
-0.0077996827,
0.033999287,
0.012052865,
0.014683295,
0.0008240541,
-0.013067085,
0.008820446,
0.00010024629,
0.038710505,
-0.010063685,
0.020022675,
0.0043971366,
0.0050154836,
0.016724823,
-0.028188786,
0.007897832,
-0.012419293,
-0.0076230117,
-0.01525911,
-0.0038376793,
0.012347316,
0.0035792168,
0.013937352,
-0.008735383,
-0.006726572,
0.023961777,
-0.016122833,
0.0006490193,
-0.03784678,
0.009599105,
-0.0009054371,
-0.029183377,
-0.013466231,
-0.008709209,
-0.008329694,
-0.0032046095,
0.0035235982,
-0.049075183,
0.00717152,
0.014905769,
-0.043997537,
0.03470597,
0.015952706,
0.018347574,
-0.019093517,
0.0078324,
0.016345307,
0.0025568171,
0.011660264,
-0.009167245,
-0.011359269,
0.00008567709,
-0.023739303,
0.007668815,
-0.0060395193,
-0.008525996,
0.004135402,
0.029890059,
-0.017274465,
0.016986556,
-0.04143254,
0.008473649,
0.013597097,
0.013132519,
-0.005012212,
0.001334027,
-0.016463088,
0.0071060867,
-0.00705374,
-0.0029608693,
0.013662531,
0.026539858,
-0.008970943,
-0.0053917267,
0.011751871,
0.057581548,
-0.001976094,
-0.007518318,
0.0016317498,
0.013963525,
0.04195601,
0.009376632,
0.002455395,
0.0051921546,
0.0049631367,
0.0041942922,
-0.0066971267,
0.05056707,
0.007819313,
-0.035360307,
-0.009527129,
-0.03104169,
-0.000987229,
-0.10982372,
-0.047269218,
0.007295844,
0.0056403745,
-0.005172524,
0.008133394,
-0.0064124907,
0.012144472,
0.0008702666,
0.058314405,
-0.0078324,
-0.032140974,
-0.02510032,
-0.012910045,
-0.009612192,
-0.012268796,
-0.005604386,
-0.011143338,
-0.0063863173,
0.02860756,
-0.00008905101,
-0.019119691,
-0.018059667,
-0.008081047,
-0.006029704,
0.0076360987,
-0.023608435,
0.020048847,
-0.001874672,
-0.018282142,
-0.01153594,
-0.007995984,
-0.0005733617,
-0.0029821354,
-0.015586278,
-0.009474782,
0.0020235335,
-0.02430203,
0.020677011,
-0.017078163,
0.0046686856,
0.028241131,
0.021776294,
-0.0005790872,
0.00058235886,
-0.017981147,
-0.040464126,
0.0063634156,
-0.011117165,
-0.016306048,
-0.0121313855,
-0.011941628,
-0.022757798,
0.013060542,
0.018282142,
-0.0039162,
0.021409867,
-0.00013689931,
-0.010560979,
-0.029392764,
-0.003536685,
-0.020663925,
-0.045489423,
0.029235722,
-0.0036053902,
-0.020925658,
-0.021697775,
-0.014133653,
-0.0069948495,
-0.036511935,
-0.009631823,
-0.0024979268,
-0.016567782,
0.002700771,
-0.037558872,
0.0058072302,
-0.0109470375,
-0.008957856,
0.018975738,
-0.008643775,
-0.010554436,
-0.02983771,
0.033214085,
-0.012222992,
0.041798968,
0.01788954,
-0.009965534,
0.0018517702,
-0.008676493,
-0.00968417,
0.026670726,
0.042296264,
-0.0007528951,
-0.012772635,
0.0020693368,
0.0039031128,
-0.009808493,
-0.012314599,
0.001507426,
0.00707337,
-0.011090991,
-0.0018926662,
-0.059466034,
0.012124842,
0.018347574,
-0.0054866057,
-0.0016898222,
-0.019577727,
0.025270447,
-0.0011737148,
0.01662013,
0.019970328,
-0.023543002,
0.023582261,
0.018491529,
-0.015324544,
-0.018949565,
-0.010030967,
0.018478442,
0.01880561,
0.031774547,
-0.0034189045,
-0.010109488,
0.023935603,
0.014971202,
-0.001446082,
0.016580869,
0.00028708982,
-0.036642805,
-0.012720288,
-0.012523986,
-0.0044363965,
-0.0005991262,
-0.013400797,
-0.018216709,
0.007897832,
-0.020101195,
-0.029131029,
-0.0011499951,
0.03227184,
0.01737916,
0.043290854,
-0.008643775,
-0.04232244,
-0.01987872,
-0.0037166271,
-0.0007933821,
-0.017078163,
-0.026160344,
0.021920249,
-0.0022770886,
0.007256584,
0.017025817,
0.00991973,
-0.03609316,
-0.032010105,
-0.034130152,
0.037558872,
0.022548411,
-0.002831638,
0.0032160603,
0.024616111,
0.036407243,
0.029628323,
0.0032782222,
-0.0013086715,
0.009533673,
-0.006592433,
-0.0231504,
-0.000570499,
0.021239739,
-0.021226652,
-0.024576852,
-0.020009588,
0.00071976933,
0.0050580157,
0.004047067,
-0.010744194,
-0.028371999,
0.029209549,
0.0040372517,
0.007223867,
0.01860931,
-0.024498332,
-0.009749603,
0.0049304203,
0.018059667,
0.018700916,
-0.021776294,
0.004544362,
0.00086045155,
0.011411616,
0.0045378185,
0.028790774,
0.0051169056,
0.020389102,
-0.01578258,
0.0056730914,
-0.0019433773,
0.001783065,
0.011405072,
0.02430203,
0.02012737,
-0.007060283,
-0.003677367,
-0.020467622,
-0.02944511,
0.012654854,
-0.04266269,
-0.0065760748,
-0.02287558,
0.01833449,
0.0071649766,
0.016842604,
0.010848887,
-0.00796981,
-0.01521985,
0.020218976,
-0.009317742,
0.0019499207,
-0.021540733,
0.029759191,
0.015612451,
0.0066513233,
-0.01597888,
-0.0066578668,
0.006955589,
0.015193677,
0.004920605,
-0.03577908,
0.00806796,
-0.024092643,
0.020978006,
0.008002526,
-0.0072893007,
-0.017431505,
-0.01173224,
-0.012458554,
-0.009546759,
0.00046989488,
-0.019577727,
0.071819894,
0.00315717,
-0.003065563,
0.024629198,
-0.017235205,
0.0049991254,
0.020088108,
0.0077407924,
0.0015859463,
-0.02566305,
0.024655372,
-0.0028136438,
0.013950439,
-0.0052019693,
-0.021880988,
0.025296621,
-0.017824106,
0.029052509,
-0.00028463607,
-0.027141849,
0.0023670597,
-0.017405331,
0.045908198,
-0.0064157625,
-0.027482104,
-0.009114898,
0.019224385,
-0.0033960026,
-0.018831784,
-0.009147614,
0.013099803,
0.0018943021,
-0.036433417,
-0.0045803506,
0.037035406,
-0.032088626,
-0.005859577,
-0.01681643,
-0.003454893,
0.01165372,
0.004148489,
0.027272714,
-0.007099543,
0.0077407924,
-0.019041171,
-0.007950179,
-0.025846263,
-0.020978006,
0.00033248437
] |
The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are required for vesicular uptake and, consequently, synaptic release of neurotransmitters. Ventromedial hypothalamic (VMH) neurons are predominantly glutamatergic and express VGLUT2. To evaluate the role of glutamate release from VMH neurons, we generated mice lacking VGLUT2 | [
-0.021180037,
-0.0059469077,
0.020248754,
-0.028018316,
-0.021233253,
0.012672101,
-0.007543393,
0.0073770923,
-0.0148074,
-0.019517032,
0.01780081,
0.0020671159,
-0.014421583,
-0.0056242845,
-0.0022683395,
-0.014621144,
0.03940658,
-0.0031447434,
-0.005082145,
0.004892562,
0.015938245,
-0.0056442404,
-0.0025992775,
-0.015326259,
0.002123658,
0.027592586,
0.0094059585,
-0.032488473,
-0.02615575,
-0.008800625,
-0.0023165666,
0.010929272,
-0.021818632,
0.00858776,
0.023574766,
-0.0012414336,
0.0013886095,
-0.0080555985,
0.009765168,
0.015632251,
0.008747409,
0.0059236255,
-0.006958015,
0.0074303085,
0.009199746,
0.002078757,
-0.013437084,
-0.031344328,
-0.0070577953,
0.0072240955,
0.027140249,
0.020820828,
-0.02753937,
-0.012811794,
-0.0017328517,
-0.0079425145,
0.015512515,
0.0050355806,
0.012785186,
-0.04882584,
-0.011887163,
0.0071974876,
-0.012153244,
0.030226788,
0.003053278,
0.010623279,
-0.014115591,
0.0075034807,
0.015472603,
-0.004909192,
-0.0044535287,
0.03187649,
-0.014222023,
0.0053116395,
0.04491445,
-0.018971566,
0.0029534977,
-0.011980291,
-0.019224344,
0.0089802295,
0.016936047,
-0.027592586,
-0.027432937,
0.023774326,
0.018772006,
0.014368367,
0.011641039,
-0.005760651,
0.019357383,
-0.0068449304,
0.013809597,
0.01934408,
0.019211039,
0.009971381,
0.005750673,
0.017095696,
0.0017228737,
0.028018316,
0.0167764,
-0.0026990578,
-0.011188701,
0.010131029,
-0.020408403,
-0.024226664,
0.00552783,
0.009944772,
-0.007915906,
-0.006326073,
0.024599176,
0.0037417624,
-0.00043030267,
0.032249004,
-0.031370934,
-0.023069212,
-0.031104853,
0.017574642,
0.036107175,
0.012778534,
0.0015698771,
-0.0081553785,
0.00852124,
-0.0017478188,
0.009964729,
-0.0039346707,
0.04156183,
0.026182357,
0.014528016,
-0.016590143,
-0.011241917,
-0.01599146,
-0.012492497,
0.015911637,
0.017069088,
0.016164413,
-0.0149670495,
0.00796247,
0.0006207168,
-0.0003565068,
0.00040369458,
-0.012652146,
-0.0019689985,
0.026940688,
-0.03589431,
0.010370502,
-0.011135484,
0.035947528,
0.032222394,
0.026594784,
0.026129141,
0.015565731,
0.010756319,
-0.012851706,
0.0008402335,
-0.018998174,
0.00029559922,
0.005142013,
-0.009678692,
0.031158071,
-0.008428112,
-0.012964791,
-0.003399183,
-0.016936047,
0.009386003,
-0.0011499682,
0.025557067,
0.025384115,
0.01635067,
-0.013796293,
0.014953745,
-0.021831935,
-0.007310572,
0.025264379,
-0.02921568,
0.016443798,
-0.0368522,
0.022058105,
0.020741004,
0.011461434,
-0.016842918,
-0.011241917,
-0.013071223,
0.0102175055,
-0.0013861151,
-0.0061331643,
-0.012878315,
0.006415875,
0.016230933,
-0.039965346,
0.0013669905,
-0.026342006,
-0.0049524303,
-0.0023099147,
-0.012359456,
-0.029322112,
-0.6385941,
-0.00021411195,
0.022164537,
-0.009485783,
-0.010343894,
0.026807647,
0.008135423,
0.011428174,
0.00014551298,
0.030891988,
-0.012133288,
0.031530585,
0.0019956066,
-0.045393396,
-0.0061630984,
-0.022337489,
-0.020448316,
-0.02470561,
0.021366294,
-0.011102225,
-0.012838402,
0.012578974,
0.005138687,
0.020607963,
0.03530893,
0.024439529,
0.024519352,
-0.013796293,
-0.019370688,
0.036213607,
-0.027858667,
0.011507998,
-0.00036024855,
0.025477244,
0.048746016,
0.013403824,
-0.010516847,
0.016124502,
-0.0029485086,
0.044249248,
-0.026036013,
-0.0037683703,
0.004047755,
0.019490425,
-0.031530585,
0.021725504,
0.015472603,
0.003661938,
-0.0006410886,
-0.025690109,
0.012286284,
-0.0034823334,
-0.025357507,
0.02543733,
-0.0007604092,
0.0074768723,
0.009053402,
-0.010896012,
0.0041841217,
0.0011699244,
-0.012638842,
0.02678104,
-0.00048227157,
-0.016576838,
-0.005504548,
-0.00023323651,
-0.008368243,
0.0030882012,
0.0041541876,
0.006415875,
0.006522307,
0.021392902,
-0.0045167226,
0.007024535,
0.03616039,
0.01289827,
0.0017794159,
0.0006477406,
-0.017973764,
0.015060177,
-0.011833947,
0.001518324,
-0.020581355,
0.00034632089,
0.021126822,
-0.011388262,
-0.015552427,
0.01565886,
0.008887101,
0.010024597,
-0.0012522431,
0.018599054,
-0.018825222,
-0.03240865,
-0.0352025,
0.022949476,
-0.0062129884,
0.019397296,
0.018106803,
-0.026980601,
-0.013463692,
-0.0053216172,
0.009864949,
-0.0006676967,
0.017122304,
0.005777281,
-0.026927384,
0.015964853,
0.029189073,
-0.023761023,
-0.013264132,
-0.003355945,
-0.014581231,
-0.0046930015,
-0.002452933,
-0.025583675,
0.018439405,
-0.011488042,
0.00095955416,
-0.028124748,
-0.009445871,
-0.007091055,
0.010470282,
0.0020754307,
0.008201943,
0.001670489,
-0.0026757757,
-0.030891988,
-0.032781165,
0.0051220567,
0.005714087,
-0.00809551,
0.016590143,
-0.015259738,
0.018865135,
0.020182233,
0.03365923,
-0.0077762133,
-0.005175273,
-0.04382352,
-0.0026009406,
-0.0044502025,
-0.0053748335,
-0.010649887,
-0.010876056,
-0.014115591,
-0.012359456,
-0.014088982,
0.009811732,
-0.023242164,
-0.010057857,
-0.008893753,
-0.028231181,
0.012918226,
0.031078245,
-0.015419386,
-0.017295256,
-0.004653089,
0.006688608,
-0.0018925002,
0.013676557,
0.011674298,
-0.0034723554,
0.007836082,
-0.03645308,
-0.032887597,
0.0134171285,
0.013743077,
-0.0022833066,
-0.041269142,
-0.0050754924,
-0.014528016,
-0.007310572,
0.024452832,
-0.012645493,
0.023534853,
0.010383806,
-0.01592494,
0.0074569164,
-0.0017428297,
0.0012564006,
-0.008315028,
-0.0031347652,
0.005537808,
0.051992204,
-0.0015790237,
0.01345704,
0.021991584,
0.004090993,
0.008594412,
0.003911389,
0.0352025,
-0.022124624,
0.006076622,
-0.018452708,
-0.010556758,
0.040843412,
0.0174416,
-0.009958076,
0.024013799,
0.024785433,
-0.01352356,
-0.007264008,
-0.019250952,
0.023840846,
-0.008414808,
-0.009266267,
-0.006691934,
-0.031903096,
-0.007264008,
0.02282974,
0.0074369605,
-0.0074502644,
-0.0015100089,
-0.012718665,
-0.006675304,
-0.009984685,
0.0047628474,
-0.014235327,
-0.031291112,
0.012445933,
-0.011374957,
0.01753473,
0.014208718,
-0.012233068,
0.028284397,
-0.0016363973,
0.015286346,
-0.013051267,
-0.009485783,
0.016856223,
0.01635067,
-0.013277436,
-0.002758926,
0.033446364,
-0.012625538,
0.0089802295,
-0.0012580636,
0.025517156,
0.022337489,
0.008727453,
0.022231057,
0.0047129574,
0.009465827,
0.009558955,
-0.0019490424,
-0.00084896426,
0.008448068,
-0.012878315,
0.0073637883,
0.0039047368,
0.0054413537,
-0.009166486,
-0.0061764023,
0.0013013018,
0.0020637899,
0.0040776893,
-0.0025859736,
0.041348968,
0.031929705,
0.0006514824,
-0.015938245,
-0.023774326,
-0.024679001,
-0.005467962,
0.015672164,
0.0019058043,
0.0023431748,
0.0069181025,
-0.018665573,
-0.018625662,
-0.0032811097,
-0.022989387,
-0.014940441,
0.023188949,
-0.000081539234,
-0.00036627694,
0.017627858,
0.01194038,
0.01891835,
-0.018253148,
-0.027379721,
0.023109123,
0.02016893,
-0.010995792,
-0.009778472,
-0.022177842,
0.015312954,
-0.010044553,
-0.010051205,
0.009505739,
-0.000005749062,
-0.004782804,
-0.0056375884,
-0.011986943,
-0.013889422,
0.024984995,
0.009652084,
0.0053914636,
-0.0148074,
-0.0072174435,
0.022164537,
-0.03866155,
-0.004340444,
0.007323876,
0.013244175,
-0.012731969,
-0.01565886,
0.008002383,
0.002464574,
0.0031430803,
0.014301847,
-0.003359271,
-0.039832305,
0.0008813929,
0.0038448686,
0.002413021,
0.02010241,
0.018399492,
0.0099048605,
-0.016004765,
-0.034670338,
-0.012532409,
-0.03184988,
0.03033322,
0.0056575444,
-0.008048946,
0.014940441,
0.0058936914,
-0.010197549,
-0.023015996,
0.005813867,
0.019769808,
-0.02059466,
0.010317286,
0.0024928453,
-0.0025693434,
-0.0010693126,
0.031291112,
-0.004017821,
-0.008414808,
-0.010357198,
0.017202128,
-0.017109001,
0.015140002,
0.009938121,
0.01766777,
0.024226664,
0.010190898,
0.0023198926,
0.02365459,
0.022683395,
0.02141951,
0.0077629094,
0.010603323,
-0.0044003124,
0.0046198294,
0.016337365,
-0.027645802,
-0.047255963,
-0.022310881,
0.00051594747,
0.014222023,
0.030492868,
0.0020554748,
0.018559141,
-0.0013204264,
-0.0026292116,
-0.02908264,
-0.024878561,
0.013377216,
0.0053548776,
-0.021246558,
-0.0004377862,
0.024652394,
-0.016882831,
0.010004641,
-0.021818632,
0.0135169085,
-0.019423904,
0.0050522108,
-0.011428174,
-0.014820704,
-0.02990749,
-0.009386003,
-0.01467436,
-0.008321679,
-0.017760899,
0.0017361777,
-0.0067883884,
-0.020355187,
-0.0003386295,
-0.017308561,
-0.019423904,
0.009239659,
-0.02441292,
-0.029934099,
-0.010437022,
0.020820828,
0.01724204,
0.008581108,
0.00017409588,
-0.00093460904,
0.03743758,
-0.030652517,
-0.021033693,
-0.017814115,
-0.0022882954,
0.013543516,
0.0010709756,
0.01384951,
-0.0094924355,
-0.0004059812,
-0.023321988,
0.028869774,
-0.029322112,
0.029322112,
-0.0050023203,
-0.0040577333,
0.010057857,
0.012938183,
0.0148074,
0.02769902,
-0.014913833,
-0.003360934,
-0.026501656,
-0.011787383,
-0.045978773,
-0.009060054,
-0.0060899258,
0.0026325376,
0.008860493,
0.01724204,
-0.004599873,
0.0041408837,
-0.015525819,
-0.0022966105,
0.0048293676,
0.013490301,
0.004659741,
0.0077695614,
0.037517402,
0.0035555058,
-0.0051287087,
0.007397048,
-0.032249004,
0.031237895,
0.006013428,
-0.034696944,
0.006685282,
0.029428545,
-0.019769808,
-0.004979038,
0.022949476,
0.010703103,
0.055025525,
0.008275115,
-0.02450605,
-0.022749914,
-0.012352805,
-0.027246682,
0.011687602,
-0.00035234928,
-0.00924631,
-0.014887225,
-0.0068183225,
-0.018559141,
-0.0053748335,
0.0075300885,
-0.03296742,
-0.0046796976,
0.016297454,
0.007636521,
-0.0018891742,
-0.015392778,
-0.00023032626,
-0.045100708,
-0.01911791,
-0.010317286,
-0.046963274,
-0.0068848426,
-0.019942762,
0.013743077,
0.017082391,
0.028736735,
0.007656477,
0.01996937,
-0.00038706453,
0.00597019,
0.020115715,
0.0064890473,
0.015485907,
-0.021233253,
0.036107175,
0.0009545651,
-0.0115678655,
0.034696944,
0.02767241,
0.01690944,
0.0010393785,
0.0059402557,
-0.0062628784,
-0.01213994,
-0.029721234,
-0.024585873,
0.02908264,
-0.0035555058,
-0.00062196405,
-0.036266822,
-0.009366047,
0.012891619,
-0.0020188887,
-0.007017883,
-0.02753937,
0.017428298,
-0.035947528,
-0.00084064924,
0.007397048,
0.0074502644,
-0.018346276,
-0.017135609,
-0.0023232186,
0.0074635684,
-0.003006714,
0.011494693,
0.006964667,
0.002125321,
-0.0055710683,
-0.009585563,
0.005088797,
-0.019610161,
0.017188825,
-0.018998174,
-0.01628415,
-0.037544012,
-0.016803008,
-0.003628678,
-0.035362147,
0.022231057,
0.011507998,
-0.009864949,
0.018452708,
-0.008075555,
0.007656477,
0.026501656,
-0.017774202,
0.027073728,
-0.0056342627,
0.026674608,
0.01384951,
0.008880449,
-0.022191145,
-0.024399616,
0.0068981466,
0.019862937,
0.025929581,
0.011727515,
0.01724204,
-0.018106803,
0.0058770613,
0.015964853,
-0.016576838,
-0.038767982,
0.045845736,
0.014514712,
-0.013603385,
-0.023188949,
0.0029318787,
-0.024599176,
0.022843042,
0.00027585102,
-0.011335045,
0.00782943,
-0.01384951,
-0.0030632562,
0.027592586,
0.022922868,
0.021432815,
0.020035889,
0.023548158,
-0.0069114505,
0.008275115,
-0.024945082,
0.01615111,
-0.010623279,
0.030652517,
-0.0040677115,
0.0036852201,
0.0139426375,
0.013862814,
-0.0029102596,
-0.014448191,
-0.0011574518,
0.035388757,
-0.016204325,
-0.01105566,
0.046218246,
-0.013131091,
0.003000062,
-0.011887163,
0.010403763,
-0.0052983356,
-0.014408279,
-0.0060899258,
0.021166733,
-0.000121711215,
-0.019956065,
0.008108814,
-0.0107297115,
0.009006837,
-0.042040776,
-0.0068914946,
-0.0012821772,
-0.022377402,
-0.011275177,
-0.0059202993,
0.0024778782,
0.011002444,
-0.018199932,
0.002745622,
-0.00058122043,
0.026674608,
-0.02184524,
0.0094924355,
0.012658797,
0.021672288,
-0.011035704,
-0.0028354244,
-0.025769932,
-0.022510441,
0.008574456,
-0.016656663,
-0.026342006,
0.006076622,
0.000108199296,
0.03405835,
0.010084465,
-0.0071176635,
0.01990285,
-0.013383868,
0.009193094,
0.01529965,
0.0056841527,
0.019357383,
-0.00488591,
-0.017720986,
-0.008168682,
-0.030971814,
-0.011268525,
0.0031164722,
-0.013563473,
0.0017627858,
-0.023681197,
0.00029206532,
-0.017561337,
-0.0059934715,
0.00040140795,
-0.00908001,
-0.004061059,
-0.021339687,
-0.03046626,
0.010683147,
-0.00054671307,
-0.034218002,
-0.022523746,
0.011641039,
0.008181986,
-0.0050389064,
-0.01283175,
-0.00080738915,
0.012326197,
-0.031264503,
-0.045127317,
-0.010084465,
-0.03490981,
0.027752236,
-0.012033507,
-0.008501284,
0.005897017,
-0.011188701,
-0.030945206,
0.005255097,
-0.0044202683,
0.0020355186,
0.021818632,
0.022177842,
-0.0087806685,
-0.021698896,
0.013124439,
0.015126698,
-0.018412797,
-0.0012663787,
0.029162463,
-0.008394851,
0.033872094,
0.038874414,
-0.030891988,
-0.0035887659,
0.030093746,
-0.004603199,
-0.011428174,
0.03020018,
-0.026302094,
0.028044924,
-0.017148912,
0.0071575753,
0.007656477,
0.018253148,
0.013782989,
-0.014661056,
-0.016363973,
-0.0032079376,
-0.009944772,
-0.0049324743,
-0.012193156,
0.01619102,
0.0066121095,
0.025703412,
-0.025144642,
-0.0076764333,
0.036293432,
-0.011794034,
0.022749914,
0.036719162,
-0.0014318477,
0.00024051216,
0.00024175942,
0.006356007,
-0.008414808,
-0.002118669,
-0.008594412,
0.009173138,
0.010570062,
0.008793972,
-0.017281953,
0.0066287396,
0.007836082,
-0.02622227,
0.014634448,
-0.012745274,
0.0041242535,
-0.026967296,
0.0065289596,
0.0059834938,
-0.0065655457,
0.011035704,
0.0056276103,
0.018346276,
0.003911389,
-0.016603446,
0.0020089105,
0.006675304,
0.0060599917,
-0.00852124,
-0.011321741,
-0.0065522413,
-0.022590267,
-0.019450512,
-0.024851954,
-0.010982488,
0.17710343,
-0.0122796325,
0.0015989797,
0.013876118,
0.008601064,
0.00009676613,
0.02177872,
-0.004965734,
0.03773027,
-0.0019324124,
0.015831811,
0.022377402,
-0.018678878,
-0.0024113578,
-0.005358204,
-0.0106432345,
-0.04118932,
-0.0004205325,
-0.015113394,
-0.0039280187,
0.0034657035,
-0.0135169085,
0.021007085,
-0.00040847572,
0.037198108,
0.0025710065,
-0.0061331643,
-0.006116534,
0.016896136,
0.03576127,
-0.021632375,
-0.005541134,
0.015113394,
0.009718603,
0.00044859573,
0.0070644473,
-0.022137929,
-0.011660994,
-0.0022467205,
0.013929334,
0.0036785682,
0.0013852835,
0.003083212,
0.0071110115,
0.0007101033,
0.01223972,
0.014714273,
-0.0012688731,
-0.013590081,
0.002747285,
-0.051433433,
0.002724003,
0.012485845,
0.034324434,
-0.0068016923,
-0.0032594907,
0.020807525,
-0.0034956376,
-0.01036385,
0.046537545,
-0.021193342,
-0.0010585029,
-0.02247053,
0.03964605,
0.0046963273,
0.016324062,
-0.024572568,
-0.0067817364,
0.03238204,
0.0013653275,
0.019423904,
0.011488042,
-0.025676804,
-0.0077363015,
-0.00272234,
-0.0018658921,
0.02503821,
-0.0033359888,
-0.0053083133,
0.019610161,
-0.0046796976,
0.019450512,
-0.015898332,
-0.011348349,
-0.025051514,
-0.020634571,
0.031158071,
0.003319359,
-0.021326382,
-0.0053016613,
0.013743077,
-0.003994539,
-0.015898332,
-0.0053981156,
-0.013769685,
-0.014700968,
0.018612357,
-0.0030017248,
-0.026275486,
0.0033143698,
-0.010609975,
0.058218494,
0.01088936,
0.018785309,
-0.0032112636,
-0.004556635,
0.0011990269,
0.017774202,
-0.011275177,
-0.010071161,
-0.002446281,
-0.020355187,
-0.005730717,
-0.02441292,
0.00013304043,
0.00061281753,
0.007975774,
-0.02427988,
0.042546332,
-0.0038315647,
-0.029987315,
-0.009931468,
0.0022816435,
0.02783206,
-0.0133173475,
0.0074768723,
-0.020208843,
0.011175397,
0.00007410768,
-0.02161907,
0.00013314438,
-0.010523499,
0.0043138363,
0.01269871,
0.0035122675,
-0.0059003434,
0.0029185745,
0.0014060711,
-0.009545651,
0.028390829,
-0.011694254,
-0.016590143,
0.029162463,
0.018386189,
0.012858358,
-0.013024659,
0.014102287,
0.01565886,
-0.005903669,
-0.009731908,
-0.022164537,
-0.018958263,
-0.0050056465,
-0.021432815,
0.015964853,
-0.02510473,
-0.018173324,
-0.04786795,
-0.006109882,
-0.012445933,
-0.028710127,
-0.00085811084,
-0.0032678058,
-0.027911883,
-0.009811732,
-0.0044368985,
-0.16677949,
0.007716345,
0.009372699,
-0.03477677,
-0.005501222,
0.013244175,
0.0063360506,
-0.009326135,
-0.02184524,
0.027379721,
0.020847436,
-0.026754431,
-0.034191392,
-0.031158071,
0.002118669,
0.0028204573,
-0.004659741,
0.0011399903,
0.018266452,
0.0036153737,
0.029588193,
-0.007869341,
0.027060425,
-0.016457101,
-0.0050655147,
0.02345503,
-0.02934872,
0.011833947,
0.008328332,
-0.011787383,
-0.00556109,
0.017548034,
0.035575014,
0.0022267643,
0.041694872,
0.007323876,
0.002742296,
-0.0074968287,
0.008754061,
0.008175335,
0.02711364,
0.026262183,
-0.013616689,
0.0083549395,
-0.00084688555,
-0.0032012856,
-0.00068432675,
-0.012399369,
-0.00019675434,
-0.012326197,
0.00051927345,
0.012425977,
0.0015931593,
0.02691408,
0.019956065,
0.012578974,
0.0133173475,
0.02197828,
0.008215247,
0.00017316044,
-0.0016846246,
-0.0073704403,
0.032887597,
0.010516847,
-0.0068648867,
-0.032115962,
-0.027060425,
-0.031903096,
-0.03142415,
-0.004034451,
-0.024851954,
-0.016403886,
0.023069212,
-0.023282077,
0.013403824,
0.03937997,
0.0063526807,
0.011035704,
-0.00071592384,
0.013496952,
-0.010576715,
-0.010723059,
-0.023734413,
-0.033712447,
-0.021086909,
-0.0064391573,
0.0029451826,
0.035122674,
0.017281953,
0.019942762,
-0.00034902326,
-0.020767612,
0.0014509723,
-0.03174345,
0.01780081,
-0.010091117,
0.017654466,
-0.0038448686,
0.023388509,
-0.0053715077,
0.020820828,
-0.008414808,
-0.01704248,
-0.01704248,
0.025636893,
0.008448068,
-0.028151356,
0.027619194,
0.01905139,
-0.00047478804,
-0.0002777219,
-0.018572444,
0.0032761206,
0.010836144,
0.006731846,
0.015885029,
0.015326259,
-0.028869774,
0.048346896,
-0.0036187,
0.04797438,
-0.0031996225,
-0.005221837,
0.024838649,
0.0031064942,
-0.03687881,
-0.13580768,
-0.04491445,
0.018599054,
0.004912518,
-0.025477244,
0.010782927,
0.015911637,
0.044142816,
0.0032262306,
0.019929457,
-0.04744222,
0.006625414,
0.013084527,
-0.0074436124,
0.0026574826,
0.007643173,
0.008374896,
0.016869528,
-0.029242288,
0.02240401,
0.00031347654,
-0.00214694,
-0.00010871898,
-0.003625352,
0.007250704,
0.011840599,
-0.013570124,
0.025144642,
0.005770629,
-0.0064690914,
0.023641286,
-0.012645493,
0.02671452,
-0.0044901147,
-0.016842918,
-0.03020018,
0.0029169116,
-0.026754431,
0.031211287,
-0.004576591,
-0.01454132,
0.011102225,
0.034111567,
0.01467436,
-0.010822839,
-0.019250952,
-0.02892299,
-0.011281829,
0.013270783,
-0.0092928745,
-0.04172148,
-0.015698772,
-0.023002692,
-0.010450326,
0.022696698,
0.0014218696,
-0.0019224343,
0.0054047676,
-0.018745398,
-0.012825098,
0.008627673,
0.031796664,
-0.011714211,
-0.0010601659,
0.008035642,
-0.009898208,
-0.034696944,
-0.05108753,
0.016230933,
-0.0279651,
-0.00921305,
0.030652517,
-0.00054754457,
-0.021831935,
-0.033419758,
0.014235327,
-0.012452585,
0.0023897388,
0.0046863495,
0.00615312,
-0.031770058,
-0.022882955,
0.013104483,
0.002145277,
-0.0087806685,
0.015459299,
0.009951425,
0.0059103216,
0.001832632,
-0.010536803,
-0.014128895,
0.0153794745,
0.0034424213,
-0.01816002,
-0.0050122985,
0.015525819,
-0.015738683,
0.0130047025,
0.037677053,
0.0077961697,
-0.01572538,
-0.014488104,
-0.049038704,
0.0032811097,
-0.0025011601,
-0.008534544,
0.01078958,
-0.02036849,
0.0074569164,
-0.029987315,
0.008907057,
-0.013676557,
-0.020820828,
0.0031447434,
0.009040098,
-0.0101177255,
-0.037544012,
-0.021765415,
0.03898085,
-0.013809597,
0.0017178847,
0.033765662,
-0.005976842,
-0.008933665,
-0.002176874,
0.0243464,
-0.031823274,
-0.010743015,
-0.01947712,
0.01016429,
-0.002115343,
-0.001384452,
0.009372699,
-0.046005383,
0.019610161,
-0.003342641,
-0.0065422636,
-0.010962532,
-0.012086724,
0.017654466,
0.011368305,
0.035388757,
-0.03908728,
-0.051460043,
0.0044036387,
-0.02099378,
-0.005185251,
-0.00013563888,
-0.037065066,
0.0020504857,
-0.014714273,
-0.01648371,
0.0141421985,
0.015911637,
0.0058870395,
-0.022297578,
-0.016111197,
0.013782989,
-0.02293617,
0.0065356116,
-0.033765662,
-0.0071110115,
0.02579654,
0.012685406,
0.018758701,
-0.0017311887,
-0.009618823,
-0.0042040776,
-0.020155625,
0.00092878856,
0.029268896,
0.008561152,
-0.03020018,
0.009252963,
0.03506946,
0.023282077,
0.0038781287,
-0.010543454,
-0.0060599917,
-0.0013503605,
-0.021060301,
0.0027173508,
0.020315275,
-0.0040444294,
-0.005700783,
0.015831811,
0.03698524,
0.0016056318,
0.0050289286,
0.03781009,
0.0037617183,
-0.007709693,
0.004536679,
0.0068249744,
0.015219826,
0.0034291171,
0.0279651,
0.0352025,
-0.01098914,
-0.005531156,
0.02372111,
0.002489519,
-0.024984995,
0.010137681,
0.013995854,
-0.012771882,
0.010570062,
0.0072906157,
-0.042892236,
-0.028284397,
0.00097285816,
0.00042780815,
0.0013869465,
0.00010903079,
0.01885183,
-0.008142075,
-0.018173324,
0.010995792,
-0.008614368,
-0.008201943,
-0.0077429535,
0.023534853,
0.019596856,
0.012339501,
0.0058770613,
0.010862752,
0.026794344,
-0.0034823334,
0.03195631,
-0.0083882,
0.009911513,
-0.030652517,
0.007629869,
-0.02769902,
-0.02575663,
-0.013902726,
-0.0028869775,
0.004965734,
-0.03480338,
0.027233377,
-0.0020305295,
0.06971319,
0.0153794745,
0.00799573,
-0.012678754,
-0.0026657977,
0.015392778,
-0.0062795086,
0.03576127,
-0.010749667,
-0.020647876,
0.033712447,
-0.0074635684,
0.044568546,
-0.05188577,
-0.009891557,
-0.0019224343,
-0.007836082,
0.0071442714,
-0.0061963582,
-0.0004880921,
0.013151047,
-0.029428545,
0.022231057,
0.0014750859,
-0.017893938,
0.019224344,
0.035415363,
-0.007037839,
0.0065389373,
-0.014155502,
0.0019656725,
-0.009319482,
-0.04981034,
0.0003342641,
-0.0059269513,
0.00012233484,
-0.013097831,
-0.01865227,
-0.010476935,
0.02934872,
-0.011015749,
0.007816126,
-0.0011308438,
-0.021233253,
-0.011627734,
-0.016111197,
-0.035122674,
-0.0014135547,
-0.01036385
] |
The proto-oncogene c-src is rarely mutated in human cancers, and when overexpressed in normal cells is non- or weakly oncogenic. These observations have raised doubts about the involvement of c-src in the etiology of human tumors. However, recent studies have shown that c-Src, a non-receptor tyrosine kinase, exhibits elevated protein levels and activity in numerous types of human cancers. Furthermore, it has been found to be a critical component of multiple signaling pathways that regulate proliferation, survival, metastasis, and angiogenesis. Because of its important role in these oncogenic processes, it represents a therapeutic target ripe | [
-0.011696197,
-0.034508504,
-0.01660671,
-0.032350037,
0.0060706907,
0.020775253,
-0.0121144,
0.013018259,
-0.03982373,
-0.0003684572,
0.01814462,
0.0030842482,
0.010077346,
-0.000924094,
-0.016728126,
0.006266302,
0.031000994,
-0.018576313,
-0.00793237,
0.005638997,
-0.021733072,
0.005811,
-0.009908716,
-0.03879846,
-0.0057705287,
0.02962497,
0.009834519,
-0.03315946,
-0.007966096,
-0.03477831,
-0.0014873192,
0.019210363,
-0.009321882,
-0.0069273324,
-0.0054872297,
0.016930481,
0.020114223,
0.011743414,
-0.0012562957,
0.00676882,
0.014205416,
0.022205237,
-0.008586654,
-0.0032646826,
-0.0016567927,
-0.003912223,
0.010785594,
-0.0040977164,
-0.012788922,
0.019008007,
0.00795935,
0.020276107,
-0.009760321,
-0.0020606623,
-0.0020067005,
-0.018630276,
-0.013483679,
0.038744498,
0.033132482,
-0.03021855,
0.023446357,
-0.00764907,
-0.04076806,
0.005625507,
0.0037773186,
0.025078697,
0.013288068,
0.006694623,
-0.0057975096,
0.0037435926,
0.04036335,
0.02482238,
-0.017699435,
0.002455257,
0.0011306661,
-0.014448244,
-0.04074108,
-0.0006176085,
0.0010623708,
-0.008316847,
0.0044855657,
-0.024336724,
-0.005392797,
0.013011513,
0.013787213,
0.012289776,
0.0015615165,
0.0044450946,
-0.018306505,
0.005058909,
0.018535841,
0.019237345,
-0.011642235,
0.021260908,
-0.0099694235,
0.0011247641,
0.0055310735,
0.04427557,
-0.011271249,
-0.03194532,
-0.009989658,
-0.00065091293,
0.0047283936,
-0.016458318,
-0.01655275,
0.030110626,
0.008741794,
-0.016512278,
0.016269451,
-0.014488715,
-0.02383758,
0.03637018,
-0.007062237,
-0.020141203,
0.042575777,
-0.013193634,
0.031054955,
0.004704785,
-0.005325345,
0.0037267297,
0.009186978,
0.028626679,
0.013530895,
-0.014286359,
0.030839108,
-0.00082291587,
-0.021760054,
0.015635401,
-0.022110805,
-0.0022748227,
0.012687744,
0.016984444,
0.006610308,
0.017119348,
-0.010111072,
-0.00028624994,
-0.014070512,
-0.005460249,
-0.014421263,
-0.03593849,
-0.0018077168,
0.022097314,
-0.0044012507,
0.0037064939,
-0.011992986,
0.0034940199,
0.028491775,
0.0014788877,
0.005011692,
-0.0022326652,
0.0155274775,
-0.0063641076,
0.02927422,
-0.02703481,
0.0028987548,
0.005777274,
-0.012876609,
0.02391852,
-0.003355743,
-0.004671059,
0.018346976,
0.0094028255,
0.014286359,
-0.0018667374,
0.020856194,
0.024930304,
0.028707622,
0.013051985,
-0.004313563,
-0.007251103,
-0.006077436,
0.035857547,
-0.022124294,
0.011190306,
-0.033591155,
0.003655905,
-0.006296655,
0.013659054,
-0.023702674,
0.0024636886,
-0.027871216,
0.022690892,
0.030407416,
-0.0018734826,
0.00089627004,
-0.0047823554,
0.037179608,
-0.010360645,
-0.016026624,
-0.018346976,
-0.0019240717,
0.010050366,
-0.004080853,
-0.016647182,
-0.63156766,
-0.033375308,
-0.012876609,
-0.008047038,
0.013638819,
0.023163058,
0.023122586,
-0.0013321793,
-0.01782085,
0.01848188,
-0.03218815,
0.02167911,
0.014691072,
-0.010900263,
-0.04265672,
-0.037179608,
-0.023743145,
-0.007419733,
0.026670568,
-0.000029615696,
0.00604371,
0.00017400538,
-0.013261086,
0.023702674,
-0.004235993,
0.02546992,
0.0030926797,
-0.032323055,
0.017065385,
0.027655369,
-0.020154692,
0.024120878,
-0.0034181362,
-0.008525948,
0.042818606,
-0.009065565,
0.00811449,
0.014556167,
0.009166743,
0.050184377,
-0.010468569,
0.0061718686,
0.026832452,
-0.0044653304,
-0.027264146,
0.011082383,
-0.00636748,
-0.0021803898,
0.0033304484,
-0.0032090344,
-0.0048261993,
-0.00057081354,
-0.022475045,
-0.024161348,
0.0036322966,
-0.020195164,
0.028275928,
-0.027817253,
-0.0041685407,
0.009962678,
-0.017402647,
0.038366765,
0.008262885,
-0.0094702775,
0.028923469,
0.007541147,
-0.021787034,
-0.008391043,
-0.008923915,
0.030353453,
0.03666697,
0.028707622,
0.0021719583,
0.006667642,
-0.00006850606,
0.042845584,
-0.021247417,
0.0019510526,
0.012674253,
-0.010569747,
0.0139086265,
0.0051938132,
-0.03245796,
-0.0025007874,
-0.0022967446,
0.006040337,
-0.032673806,
0.020262616,
0.03194532,
-0.018549332,
0.0109542245,
0.00066946226,
-0.021072041,
-0.035263967,
-0.014448244,
0.03820488,
0.009308392,
0.02484936,
0.005055536,
-0.0497257,
-0.030704204,
-0.017942263,
0.02800612,
-0.00010734372,
0.016417846,
-0.014677581,
-0.021503735,
0.00013437726,
0.029651951,
-0.05285548,
0.0107046515,
-0.005622134,
-0.0015733207,
-0.012937317,
-0.014110983,
-0.011385918,
0.012249305,
0.021193456,
0.007386007,
-0.021840995,
-0.0022832542,
-0.0020404265,
0.0154600255,
-0.020208655,
0.030461377,
0.008815992,
-0.008876699,
-0.010367391,
0.02138232,
-0.031297784,
-0.0016095762,
-0.026265854,
0.024620023,
-0.02576671,
0.013638819,
0.008249394,
0.017402647,
0.018873103,
0.0005577447,
-0.012040203,
-0.013605093,
-0.007912134,
0.006890234,
0.0002693869,
0.0016011447,
-0.022002881,
-0.032053247,
0.0008511614,
-0.008040292,
0.012613546,
-0.0005940002,
0.0005459406,
-0.0009299961,
0.020397522,
0.015621911,
-0.013895136,
-0.01715982,
-0.017389156,
0.0035749623,
-0.017092368,
0.00035559913,
0.008478731,
-0.005527701,
-0.0027200067,
0.00604371,
0.004998202,
-0.0013844548,
-0.0068194093,
0.000715414,
-0.032592863,
-0.0054838574,
-0.0021888213,
-0.013753487,
0.027304618,
-0.0058177453,
0.0048194537,
-0.019034987,
-0.01335552,
0.013827684,
-0.006401206,
-0.009423061,
-0.04397878,
-0.029571008,
0.003952694,
0.025335016,
0.038150918,
0.035776604,
0.0011062147,
0.00557829,
0.020802233,
-0.015325122,
0.0097198505,
-0.015068803,
0.02742603,
-0.000005793373,
-0.027871216,
0.0001701058,
0.02103157,
-0.0037672007,
0.034643408,
0.004748629,
-0.011804121,
0.022232218,
-0.0077974647,
0.008047038,
-0.022515517,
-0.01466409,
-0.013800703,
-0.0093353735,
0.017672455,
0.0069205873,
0.026319817,
-0.011028421,
-0.0037402199,
0.021827506,
0.022326652,
0.009895226,
-0.009807538,
0.0032309564,
-0.01724076,
-0.00018338545,
0.0008709755,
-0.02198939,
-0.012033458,
0.014151455,
0.025699258,
0.011527567,
0.016161527,
-0.0055513093,
0.0012824334,
-0.013706271,
0.013632073,
0.01939923,
0.0040943436,
-0.008937405,
0.026225384,
0.004003283,
-0.015770305,
0.03529095,
0.004074108,
0.010104327,
0.0053860517,
-0.016013132,
0.007999822,
-0.0040875985,
0.0025716121,
0.028545737,
0.014421263,
-0.017078876,
-0.0002955246,
-0.0008895248,
0.019925356,
0.00047638058,
0.028464794,
-0.0020876431,
0.0022781952,
0.013409481,
0.039931655,
0.057253357,
0.0038312804,
0.004337171,
-0.021530716,
0.039877694,
-0.0007158356,
-0.0040673628,
0.019884884,
0.0023911777,
-0.0061415154,
0.023324942,
0.011412898,
-0.038933363,
0.00011372005,
0.005942532,
-0.029867798,
0.0038144174,
0.018104149,
0.013395991,
0.011561293,
0.00921396,
0.006232576,
-0.017146328,
-0.025577843,
0.029220257,
0.043169357,
0.00012425944,
-0.015581439,
-0.014124474,
0.012802412,
-0.008647362,
0.019871393,
0.00058894133,
-0.0036356691,
-0.02231316,
0.008957641,
-0.01525767,
-0.013517405,
0.0057637836,
-0.014772014,
0.015095784,
-0.0037638282,
0.008424769,
-0.0098615,
-0.005659233,
0.0065529733,
0.05067003,
0.0029678931,
0.011554548,
-0.0022410967,
-0.026508683,
-0.029975722,
0.0070824726,
-0.035614718,
0.0022242337,
-0.033833984,
-0.0026070243,
-0.0010320174,
0.034886237,
-0.0022866267,
0.006205595,
-0.0038784968,
-0.0044754483,
-0.031108918,
-0.0069273324,
0.0047654924,
0.018279525,
0.027560936,
0.0075883633,
0.00924094,
0.00016567926,
0.0058649615,
-0.0090520745,
-0.034940198,
0.022960702,
-0.019723,
-0.003979675,
0.0021078787,
-0.0009569769,
0.005794137,
0.03248494,
0.03280871,
-0.003021855,
-0.024323234,
-0.0077232677,
-0.0054501314,
0.0145426765,
-0.009901971,
0.029759875,
0.026009537,
0.026387269,
0.0044821934,
-0.00922745,
0.024323234,
0.021948919,
-0.0074871853,
-0.01305873,
0.013787213,
-0.0054906025,
-0.0038144174,
-0.01687652,
-0.01525767,
-0.007878408,
0.017308213,
0.0025884751,
0.003322017,
0.029085353,
0.0096861245,
0.025240583,
0.015122765,
-0.023810597,
-0.014866447,
0.0051836953,
-0.0020960746,
0.004370897,
-0.026657077,
0.0029122452,
-0.00057924504,
-0.024916813,
-0.03858261,
0.0035817076,
-0.00059147074,
0.019898375,
-0.007939114,
-0.0245121,
0.014218907,
-0.011149835,
-0.0094702775,
-0.0035412363,
-0.015824268,
0.0073253,
0.0058818245,
0.017308213,
-0.018576313,
-0.029759875,
0.0064045787,
0.030947031,
-0.023311453,
-0.014677581,
0.0028076945,
0.02103157,
0.008208923,
-0.013395991,
-0.0077974647,
0.001991524,
0.016296431,
-0.0008321905,
-0.0023085487,
-0.022124294,
-0.04462632,
0.011783885,
-0.007642325,
0.011500586,
-0.023594752,
-0.014205416,
0.0028700877,
-0.002203998,
-0.025996046,
-0.000034437468,
-0.023217019,
-0.0010320174,
0.0031129152,
0.0068430174,
0.007197141,
-0.0034248813,
0.0064248145,
-0.0074534593,
0.02038403,
-0.0148934275,
-0.0012841197,
-0.011999732,
-0.008343827,
-0.0012621977,
-0.008654106,
-0.005305109,
-0.010171779,
0.021557696,
-0.013551131,
0.00013132085,
0.005372561,
0.007230867,
0.027102262,
0.0075951084,
-0.0058649615,
0.0017689319,
-0.0055411914,
-0.014947389,
0.00074113015,
0.036235277,
-0.001257982,
0.004893651,
0.0074939304,
0.0015969289,
-0.008445005,
-0.027844235,
-0.018967535,
-0.024781909,
0.023797108,
-0.000092377784,
-0.0010657435,
-0.00350751,
-0.001430828,
0.001720029,
-0.0040943436,
0.00041377658,
-0.009166743,
-0.02706179,
0.015365592,
0.011082383,
-0.013234106,
-0.0012900218,
-0.040579196,
-0.024916813,
0.023635222,
0.00022575381,
-0.022974191,
0.008876699,
0.0171868,
0.0016062036,
-0.0013692781,
0.0047351387,
-0.021072041,
-0.0070824726,
-0.0024046681,
0.030758167,
0.029058373,
0.026157932,
0.0075344015,
0.02830291,
0.024039935,
0.012013222,
-0.011008185,
-0.018239053,
0.009510749,
-0.03407681,
0.021787034,
0.008984623,
0.015999643,
0.03051534,
0.0028127534,
-0.008728304,
0.01876518,
-0.006947568,
-0.007939114,
0.0038616338,
-0.048835333,
-0.0242288,
0.032619845,
-0.019844413,
0.0025260819,
-0.03402285,
-0.009537729,
0.03574962,
-0.010192015,
-0.017685946,
0.023217019,
0.00939608,
0.0060740635,
-0.005038673,
-0.027223675,
-0.00012931836,
-0.022529008,
-0.017888302,
0.002332157,
0.00011624951,
0.015014841,
0.0048498074,
0.0052578924,
0.015513987,
-0.007736758,
-0.014367301,
0.003500765,
-0.00987499,
-0.027156223,
-0.0028785192,
-0.004630588,
-0.0020168184,
-0.0014240829,
-0.018873103,
-0.0419822,
-0.00085790665,
0.025658786,
-0.024053425,
0.008391043,
0.008316847,
-0.010738377,
0.041523524,
0.0035378637,
0.03782715,
-0.029058373,
0.013112692,
0.026791982,
0.01081932,
-0.024579551,
-0.016350394,
0.008815992,
0.000712463,
0.031918343,
0.0017925401,
0.0055513093,
-0.00061002007,
0.010947479,
0.001964543,
-0.01004362,
-0.033132482,
0.026872924,
-0.0100031495,
0.013868156,
-0.021490244,
-0.019790452,
-0.0085934,
0.015014841,
0.0044552125,
-0.012971043,
-0.0024350216,
-0.020397522,
-0.019466681,
0.02166562,
-0.014097493,
0.028464794,
0.011082383,
-0.023635222,
-0.02544294,
0.0035108828,
-0.0063978336,
0.0057840194,
-0.019385738,
0.041847296,
0.0012790608,
0.0003425303,
0.012539349,
0.0016399296,
-0.002031995,
-0.0026525545,
-0.0063539897,
0.04300747,
0.003655905,
-0.0040774806,
0.018697727,
-0.0064315596,
-0.008107745,
0.0028346754,
-0.00020309411,
-0.040875982,
-0.054204524,
-0.00066693284,
0.033914924,
0.0078177005,
-0.0011660785,
-0.007068982,
-0.016957462,
-0.010293193,
-0.025510391,
-0.028275928,
0.012471897,
-0.031972304,
-0.023217019,
-0.026845943,
0.01400306,
0.009220704,
0.025200112,
-0.025672276,
0.006205595,
0.052990384,
-0.015689362,
0.010583238,
0.002220861,
0.02100459,
-0.02320353,
0.002677849,
0.0050690267,
-0.025011245,
0.0116557265,
0.0041179517,
-0.036639992,
-0.026791982,
0.013436462,
0.0059189233,
0.029705914,
-0.006947568,
0.020006299,
0.021517226,
0.001569948,
-0.0059357863,
-0.016148036,
0.0040538725,
0.0033439388,
-0.009058819,
0.018954046,
-0.023244,
-0.016026624,
-0.009692869,
0.00044813502,
-0.00014913242,
-0.005723312,
-0.0070554917,
-0.017685946,
-0.0020168184,
-0.023729656,
0.0021837624,
-0.021193456,
-0.0051499694,
-0.020815725,
0.012478642,
0.0045496454,
-0.0051769502,
-0.019803941,
-0.015338612,
-0.025834162,
0.0034063319,
-0.019682528,
0.0029577755,
-0.01335552,
-0.015406064,
-0.031918343,
-0.007318555,
-0.020910157,
0.026225384,
0.019466681,
-0.020276107,
-0.031999286,
0.0016019879,
-0.055121873,
0.0077839745,
0.011102619,
0.014151455,
0.013011513,
0.022097314,
-0.0094365515,
0.0050521637,
-0.009133017,
0.031081935,
0.003841398,
-0.024943793,
0.003956067,
0.011824356,
0.006880116,
0.020680819,
-0.02193543,
-0.010225741,
0.036532067,
0.0010311742,
-0.013004769,
0.016390866,
-0.015392574,
0.01939923,
-0.003490647,
0.01065069,
-0.0020808978,
0.009868245,
0.015554459,
-0.023028154,
0.003918968,
0.026643587,
0.011547803,
-0.01881914,
0.009901971,
-0.021220436,
0.026603116,
-0.0099694235,
0.0041179517,
-0.014718052,
0.0026795354,
-0.0032444468,
0.014421263,
0.027925177,
-0.0042225025,
0.031648535,
-0.0014569658,
-0.0016180077,
-0.024350215,
-0.012863119,
-0.021881467,
0.004276464,
-0.010475314,
0.013153163,
-0.025631806,
0.004037009,
0.0032326428,
-0.0146506,
0.0072173765,
0.01128474,
-0.019345267,
-0.03062326,
0.007905388,
0.0032495058,
-0.022083825,
0.01193228,
0.013315048,
-0.033860963,
-0.04276464,
-0.0022478418,
0.00843826,
-0.02256948,
-0.019574605,
-0.012930571,
-0.0054535037,
-0.018805651,
-0.023675693,
-0.0078851525,
-0.01784783,
0.0242288,
0.18400937,
-0.0051432243,
-0.016053604,
0.021395812,
0.005274756,
-0.023014663,
0.036774896,
-0.0072173765,
-0.0026845944,
-0.0044720755,
0.0028313026,
0.010421352,
-0.0034215087,
-0.005861589,
0.027628388,
0.020856194,
-0.006330381,
-0.0037672007,
0.0041280696,
-0.022529008,
0.0048025907,
-0.022448065,
0.004006656,
-0.018846123,
0.022164766,
-0.0064079515,
-0.021314869,
-0.009740086,
0.03529095,
-0.0041955216,
-0.05002249,
0.02293372,
0.0018178346,
0.003612061,
-0.016148036,
0.016296431,
0.0014257692,
0.0051769502,
-0.0019628566,
-0.010434843,
-0.0014282987,
-0.013868156,
0.007966096,
-0.01942621,
0.006701368,
0.017024914,
-0.005433268,
-0.016282942,
0.0064248145,
-0.012519113,
-0.024606533,
0.015041823,
0.020114223,
0.0057705287,
-0.017955754,
-0.00005975836,
0.024647005,
0.012930571,
-0.003038718,
-0.0025783572,
-0.006583327,
-0.0135578755,
-0.03218815,
-0.0016222234,
-0.023797108,
0.030461377,
-0.014164945,
0.004998202,
0.025901614,
-0.014596638,
-0.025591334,
0.0011652353,
-0.019008007,
0.003500765,
-0.011554548,
-0.016040115,
0.022083825,
0.006728349,
0.028896488,
0.012863119,
-0.008775521,
0.012181853,
-0.010711396,
0.0184549,
0.008195433,
-0.012802412,
0.022758344,
0.0090858005,
-0.0019139538,
0.009578201,
0.010502295,
-0.012701234,
-0.012849629,
-0.025834162,
0.01622898,
0.0018549332,
-0.0056187613,
0.017227272,
0.0023827462,
-0.019021498,
-0.015406064,
0.07257848,
0.004998202,
-0.00010333875,
-0.009443297,
-0.0078514265,
-0.011716433,
0.004397878,
-0.016269451,
-0.002649182,
-0.0003250349,
-0.028275928,
0.0082021775,
-0.000027903045,
0.00764907,
0.014960879,
0.0042056395,
-0.036343202,
0.008505712,
-0.010326919,
-0.013139673,
-0.031567592,
0.0010286449,
0.03178344,
0.009038584,
0.023621732,
-0.004047127,
-0.0051836953,
-0.0037469652,
-0.039014306,
0.0035951978,
-0.00874854,
-0.013449952,
0.03027251,
0.0064551677,
-0.039068267,
0.009713105,
-0.0068497625,
0.008930661,
0.0109542245,
-0.010981205,
-0.0070487466,
0.010515785,
0.014758524,
0.0005851471,
-0.022421084,
0.0054568765,
0.028275928,
0.0027756547,
-0.0028093806,
-0.00064543245,
-0.013733251,
0.016296431,
0.0031989168,
0.0045294096,
-0.02518662,
0.00028287733,
-0.024620023,
-0.0019004635,
0.025388977,
-0.02806008,
0.019669037,
0.020181675,
-0.022421084,
-0.014812485,
-0.0141919255,
-0.1703031,
0.013841175,
0.0040875985,
-0.03604641,
0.019965827,
0.004381015,
0.006377598,
-0.0026171422,
0.0064517953,
0.001836384,
0.03828582,
-0.012141381,
-0.04492311,
-0.011345446,
-0.0029594616,
-0.0031196605,
-0.0042123846,
0.022690892,
0.02480889,
0.012869864,
0.01749708,
-0.019520642,
0.036181316,
0.0003128092,
-0.01597266,
0.025348507,
0.0035985706,
-0.04298049,
-0.0028245575,
-0.0074736946,
-0.0015109275,
0.010610218,
0.021193456,
-0.010252722,
0.025429448,
0.017375667,
0.0038919873,
-0.0045563905,
-0.02135534,
-0.0042663463,
0.017564531,
0.028680641,
0.02671104,
-0.0010986264,
-0.024593042,
0.015594929,
0.025240583,
-0.008795756,
0.024700966,
0.007905388,
0.042548798,
0.0022124294,
0.0011643922,
0.010138053,
0.008681088,
0.002721693,
0.010488804,
0.012141381,
0.004414741,
0.012701234,
-0.010117818,
-0.032269094,
0.02008724,
-0.022083825,
-0.007352281,
-0.018522352,
-0.0058278632,
0.011028421,
-0.037449416,
0.007628835,
-0.010616964,
0.024606533,
0.0007107767,
-0.016566241,
0.00011846278,
0.019021498,
-0.019169891,
0.02166562,
-0.020599877,
-0.0015092412,
0.022380613,
-0.005325345,
-0.01657973,
-0.014245887,
-0.011817611,
0.00092662347,
0.023163058,
-0.0011483723,
0.030974014,
-0.027790273,
0.00795935,
-0.01525767,
-0.011507331,
0.0018566196,
0.016930481,
0.010576492,
0.00795935,
0.0015927132,
-0.021409303,
-0.017132837,
0.019615076,
-0.016512278,
-0.014110983,
-0.004886906,
0.04241389,
0.013510659,
-0.0033877827,
0.0033085265,
0.016984444,
0.0065361103,
-0.02389154,
0.00012436484,
0.023945503,
0.011264504,
-0.009760321,
0.0419822,
0.009362354,
0.003696376,
0.01179063,
-0.021436283,
0.058062784,
0.0025614942,
0.0022579597,
0.021126004,
-0.007359026,
-0.031567592,
-0.12109004,
-0.038366765,
0.02959799,
-0.008667598,
-0.025915103,
0.029948741,
-0.003773946,
0.02449861,
-0.019534133,
0.02328447,
-0.022097314,
-0.017928774,
0.003323703,
0.0052410294,
0.012006477,
-0.0038987324,
0.032107208,
-0.0020960746,
-0.022825796,
0.01660671,
0.0065057566,
-0.0010556256,
-0.007655815,
-0.020910157,
-0.0051533417,
0.028275928,
-0.03216117,
-0.0035682172,
-0.00010960969,
-0.0002658035,
0.011358936,
-0.0047283936,
0.028087063,
-0.006573209,
-0.003959439,
0.012950807,
-0.0001216246,
-0.02927422,
0.036639992,
-0.0065259924,
0.012485387,
0.012944061,
0.024539081,
-0.0021854485,
-0.016431335,
-0.011433134,
-0.03604641,
0.023999464,
0.025227092,
-0.04551669,
-0.041469563,
-0.0077974647,
-0.02167911,
-0.011257758,
0.012370719,
-0.008613636,
-0.02130138,
0.0045058015,
-0.0010438216,
-0.015014841,
-0.00073775754,
-0.00798633,
0.028383851,
0.0056187613,
0.009186978,
-0.013800703,
-0.004124697,
-0.021894958,
0.034562465,
-0.024539081,
0.012026712,
-0.009713105,
-0.038150918,
-0.0019611702,
-0.021733072,
-0.014448244,
-0.0012723156,
-0.018886594,
0.010266213,
-0.025267564,
-0.016647182,
-0.010718142,
0.010886772,
-0.04899722,
0.015824268,
0.011291484,
0.0035041375,
-0.01815811,
0.009200469,
-0.012647272,
0.0074669495,
0.028168004,
-0.007392752,
-0.0026171422,
0.004593489,
0.0046676868,
0.0003652954,
0.0032697415,
-0.0012773745,
0.029436104,
-0.02320353,
-0.015230688,
-0.053691886,
-0.0011677648,
0.0011551175,
-0.010394371,
0.010630454,
-0.006974549,
0.0025969066,
-0.016485298,
-0.0054906025,
0.0119727515,
0.0044012507,
-0.004327053,
-0.0063371267,
0.009868245,
-0.019008007,
0.00469804,
0.028437814,
-0.01403004,
0.0034636662,
0.022326652,
-0.0034636662,
-0.026252365,
0.016633693,
-0.005372561,
-0.0017571277,
0.007574873,
-0.00621234,
0.013234106,
-0.0025817298,
0.008654106,
0.0293012,
-0.042225026,
-0.012680998,
-0.0045395275,
-0.004640706,
-0.013342029,
0.00025463174,
0.04203616,
0.012262795,
0.038690533,
-0.01779387,
-0.012795667,
0.014084002,
0.015702853,
0.0030673852,
0.009665889,
-0.030731184,
0.003367547,
0.022879759,
0.018967535,
0.0037874365,
0.009935697,
-0.018711217,
-0.013193634,
-0.011372427,
-0.020046769,
0.02008724,
-0.0083842985,
-0.034211714,
-0.026238874,
0.025955575,
0.022852778,
-0.00026158776,
0.013483679,
-0.016363883,
-0.00811449,
-0.029786855,
0.0033489978,
0.019183382,
-0.019008007,
-0.03626226,
0.018387448,
0.0005526858,
0.0044754483,
0.014906919,
-0.009618673,
-0.02806008,
-0.0096861245,
-0.0032140934,
0.02100459,
0.019520642,
0.00988848,
-0.009598437,
0.018063677,
0.024754927,
0.011696197,
0.004610352,
0.016647182,
-0.0021213691,
0.005554682,
0.0047857277,
0.016175019,
0.009713105,
0.012991278,
0.007682796,
0.03148665,
-0.021773543,
0.01463711,
0.0025412585,
0.02797914,
0.000146076,
-0.029921759,
0.007912134,
-0.012148127,
-0.02069431,
0.01977696,
-0.047216482,
-0.03472435,
-0.0356417,
-0.019331777,
0.023743145,
0.0025142778,
0.0071296887,
-0.009827774,
-0.015743325,
-0.01083281,
0.025051717,
-0.02037054,
-0.011756904,
0.019601585,
0.016040115,
0.012208833,
0.0067485846,
-0.008080764,
0.02325749,
-0.0094028255,
0.04233295,
-0.042198047,
0.001991524,
-0.0141919255,
-0.0048801606,
-0.011939025,
-0.043843877,
-0.020019788,
-0.015028332,
-0.018198581,
0.024336724,
0.003979675,
-0.016094076,
0.082831204,
0.0068936064,
-0.014812485,
-0.011149835,
-0.0058413534,
0.036532067,
0.024080407,
0.009079055,
-0.03245796,
-0.027925177,
0.0058413534,
-0.036154337,
0.02770933,
-0.03208023,
-0.017888302,
0.022717873,
-0.00922745,
0.0037435926,
-0.00045445864,
-0.0037166118,
-0.00050799875,
-0.016701145,
0.008498967,
0.023419376,
-0.03021855,
-0.008586654,
0.029786855,
0.0013793958,
0.011089128,
-0.047054596,
-0.015041823,
-0.012283031,
-0.039122228,
-0.005649115,
0.006579954,
-0.020788742,
-0.002510905,
-0.031000994,
0.011534312,
0.011082383,
0.013456698,
0.005065654,
-0.0034113908,
-0.013665799,
0.018009715,
-0.004741884,
-0.0145426765,
0.0041112066,
0.012802412
] |
Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory responses when compared with nondiseased, control individuals. Treg dysfunction could be a primary, causal event or may result from perturbations in the immune system during disease development. Polymorphisms in genes associated with Treg function, such as IL2RA, confer a higher risk of autoimmune disease. Although this suggests a primary role for defective Tregs in autoimmunity, a | [
-0.02542612,
-0.010464938,
0.0017041679,
-0.027661093,
-0.027477037,
0.016354753,
-0.008348286,
0.01692007,
-0.015289853,
-0.0174328,
0.0036778473,
-0.010096825,
0.009636683,
0.0047493204,
-0.0109973885,
0.008893883,
0.045882706,
0.0020114768,
-0.007329401,
0.009202835,
-0.026122905,
0.021232255,
-0.004210297,
-0.009104233,
-0.010221721,
0.007184785,
0.010681862,
-0.04795992,
-0.017367065,
-0.018865813,
0.019286513,
-0.007868424,
-0.01330467,
-0.0056498833,
0.010464938,
-0.03988772,
0.007776396,
-0.006921847,
0.03226251,
-0.009610389,
0.02095617,
0.01981239,
0.0044732355,
0.008913604,
0.007506884,
0.017156715,
0.018865813,
0.009025352,
-0.0054921205,
0.022967648,
0.022941353,
0.014501039,
-0.031868104,
-0.009071366,
-0.022034217,
-0.0071453443,
-0.0138174,
0.014132925,
-0.007296534,
-0.042122692,
-0.008637519,
0.0023763035,
-0.023072822,
0.0040032333,
0.015526498,
0.009137101,
0.014632508,
0.023151703,
-0.0037172881,
-0.016144402,
0.02244177,
0.026924867,
-0.006244781,
-0.0077895424,
0.01311404,
-0.02873914,
-0.0039867996,
0.021771278,
-0.0038487571,
0.0049761045,
0.011477251,
-0.016801748,
0.00471974,
0.026859133,
0.008032761,
0.0025751505,
0.00784213,
-0.0018093431,
0.016249578,
-0.018221613,
-0.002473262,
0.00709933,
0.01419866,
0.024058841,
-0.0006852826,
0.0044206474,
0.01819532,
0.03178922,
-0.01916819,
-0.012035994,
0.0009621893,
0.014895447,
-0.0014642368,
-0.020206796,
-0.03334056,
0.0081313625,
0.008039334,
0.0054789735,
-0.0073622684,
-0.03171034,
-0.026333256,
0.03468154,
-0.019220779,
-0.02750333,
0.0072373725,
0.015145238,
0.00419715,
-0.010931654,
-0.022126244,
-0.019838683,
0.02546556,
0.021113934,
0.009189689,
-0.013922575,
0.021390019,
0.02160037,
-0.012272638,
0.023138557,
-0.015802583,
0.0038093163,
0.004680299,
0.021902747,
0.0014395864,
0.0016269299,
-0.0063368096,
-0.0010435358,
-0.037047986,
0.0039670793,
-0.002044344,
-0.0068692593,
-0.0018570006,
0.031736635,
-0.021915894,
0.007329401,
0.01730133,
0.029764598,
0.024637304,
0.0005077993,
-0.0014716319,
-0.0019473856,
-0.01798497,
-0.016814895,
0.00040878664,
-0.020943023,
0.014658802,
0.010129692,
-0.009419759,
0.031184465,
-0.026556753,
-0.014211807,
0.008262832,
-0.017064685,
0.008578357,
0.012154316,
0.016841188,
0.022468064,
-0.00026725198,
0.020219944,
-0.000342025,
0.0062382077,
-0.0068429653,
0.024308631,
-0.00037550853,
0.00290711,
-0.009248849,
0.013909428,
-0.017971823,
-0.0042760316,
-0.0163679,
-0.010215147,
-0.011056549,
0.030421944,
0.0208247,
0.008072201,
-0.01328495,
0.0060344306,
0.024269192,
0.009847034,
-0.006639188,
-0.01162844,
-0.0057254783,
0.0035069375,
0.00068322837,
-0.043989554,
-0.6297895,
-0.036574695,
0.04154423,
-0.0058306535,
-0.0045521166,
0.04086059,
0.01713042,
0.00005402557,
-0.039361842,
-0.0024305345,
-0.012187183,
0.030658588,
0.011773055,
-0.027687388,
-0.01632846,
-0.026070317,
0.0014905307,
-0.015421323,
0.019825537,
-0.005551282,
0.004111695,
0.0074411496,
-0.0031667612,
0.000011927224,
0.0045192493,
-0.0040591075,
0.003694281,
-0.0027411303,
0.002093645,
0.029580541,
-0.010931654,
0.0021528061,
-0.009952209,
0.0028824594,
0.048985377,
0.011444383,
-0.018090144,
0.018418817,
0.0009876614,
0.04072912,
-0.009827313,
0.007000728,
0.03405049,
0.0018635741,
0.0010599694,
0.012667045,
-0.012305506,
0.0022234707,
0.029527955,
-0.00982074,
0.017919235,
0.019667774,
-0.010136265,
-0.0054132394,
0.04714481,
-0.013515021,
0.011700748,
-0.012423827,
0.030421944,
-0.0074477233,
0.0022267574,
0.02826585,
-0.015763141,
-0.0051305806,
-0.01330467,
0.0024075275,
0.00023890396,
0.0059522623,
0.0014658802,
0.014632508,
0.009570949,
0.022244567,
-0.014724537,
-0.00020490687,
0.0000035435023,
0.02643843,
0.008177376,
-0.012837955,
-0.0033393146,
0.016078668,
-0.010478085,
-0.00022781125,
-0.0013697434,
0.0024354646,
0.010090251,
-0.0050319787,
-0.0030418658,
0.016315313,
-0.0265699,
0.027450742,
0.022428624,
-0.0007649857,
-0.0042333044,
-0.042490806,
-0.031000407,
0.036180288,
-0.010155986,
-0.0028956064,
0.000673779,
-0.0072242254,
0.0013828903,
-0.007027022,
-0.0071321973,
0.0077566756,
0.0189184,
0.0068889796,
-0.04264857,
0.0015291497,
0.05292945,
-0.026977453,
-0.0005427208,
0.0051930286,
0.008216817,
-0.0047854744,
0.027687388,
-0.012206904,
0.009176541,
-0.0009761579,
0.0070467424,
-0.017551122,
0.016354753,
-0.0020246238,
0.015066356,
-0.0036811342,
-0.0048840763,
0.0004100192,
-0.0065734535,
-0.010780464,
0.009492068,
-0.012114875,
-0.0021347292,
0.003237426,
0.01874749,
-0.01513209,
0.030868938,
-0.019115603,
0.040282123,
0.006313802,
-0.0017534688,
-0.02478192,
-0.027240392,
-0.020469734,
0.001202942,
-0.0062842215,
0.0028430186,
0.0078552775,
-0.0018126299,
-0.0119505385,
0.030185299,
0.009781299,
0.012141169,
-0.0059785563,
-0.0026918293,
0.014934887,
0.017038392,
-0.0025521433,
-0.015920905,
-0.02499227,
0.025820525,
0.0049037966,
-0.002713193,
0.015592232,
0.015040062,
-0.0047854744,
-0.021758132,
-0.013035159,
-0.009511787,
0.017314477,
-0.019457422,
-0.04067653,
-0.02061435,
-0.022113098,
-0.0025981576,
0.026806545,
-0.009623536,
0.017051538,
-0.010957947,
-0.009031925,
-0.004088688,
-0.005557855,
-0.02653046,
-0.003043509,
-0.004677012,
-0.005728765,
0.024374366,
-0.009597243,
0.017616857,
-0.022612682,
0.009577522,
0.045225363,
-0.037179455,
0.01347558,
-0.014711389,
0.02605717,
-0.0012826452,
-0.02771368,
0.015526498,
0.015539644,
-0.005137154,
0.025360385,
-0.018169027,
-0.03838897,
0.016262725,
-0.049511254,
0.025412973,
-0.044357665,
-0.002920257,
-0.023782756,
0.012417254,
0.010504379,
-0.025610175,
0.011326061,
0.009156821,
0.004443655,
0.009847034,
0.02992236,
-0.0029432639,
-0.005304777,
0.0092882905,
-0.020850996,
-0.0007119872,
0.027871443,
0.029606836,
-0.027818857,
-0.020219944,
0.0044469414,
0.0246636,
-0.0053935186,
-0.003128964,
-0.0071782116,
-0.021955336,
-0.014159219,
0.007579192,
0.009853607,
0.0031437543,
0.017945528,
-0.0076843672,
-0.025873113,
0.030632295,
0.00746087,
0.009814166,
-0.0009942349,
0.0036844208,
0.011128857,
-0.030369356,
-0.01713042,
0.03554924,
-0.0016680139,
-0.014671949,
0.035917353,
-0.009215982,
-0.004561977,
-0.001474097,
0.004443655,
-0.008749267,
0.0060147103,
0.015447617,
0.00043179374,
0.039230373,
0.017577415,
0.016775453,
-0.014172366,
0.001804413,
-0.01216089,
-0.0062184874,
-0.0040295273,
0.004838062,
-0.014093485,
-0.005580862,
-0.0051207202,
-0.047013342,
0.019483717,
0.03115817,
-0.023072822,
0.013357258,
0.02529465,
0.010911933,
-0.0046014176,
0.019523157,
0.004775614,
-0.0020098335,
-0.037389804,
0.03168405,
0.023072822,
0.002658962,
-0.008867589,
-0.035075948,
-0.0068166717,
0.0016524019,
-0.0014486249,
0.007303107,
0.015329294,
0.027766269,
0.012870822,
0.01496118,
-0.0018553573,
0.043095563,
-0.014290689,
0.0059851296,
-0.007861851,
0.011036829,
-0.004164283,
-0.006596461,
0.014724537,
0.027371861,
0.026293814,
0.004308899,
-0.009189689,
-0.021416312,
-0.0059489757,
0.0022678415,
0.0054362463,
0.0043614865,
-0.014356423,
0.015973493,
0.008821575,
0.011957113,
0.018681755,
0.026359549,
0.0048643555,
-0.004801908,
-0.027950326,
0.01073445,
0.0073359744,
0.02643843,
0.01577629,
-0.005557855,
0.019286513,
-0.010622702,
0.02015421,
-0.020390853,
-0.04604047,
0.036416933,
-0.009294864,
-0.016433634,
0.007572619,
0.025347238,
-0.0010312105,
0.013528168,
0.020627499,
0.0015611952,
-0.0010082035,
0.0045948443,
0.0142381005,
-0.0065931743,
0.0072505195,
0.031526282,
0.018944694,
0.03894114,
-0.022954501,
0.0015094293,
0.013179774,
-0.010833052,
-0.003694281,
-0.0060212836,
0.027529623,
0.0010090251,
0.014737683,
-0.011135431,
-0.01895784,
0.0109710945,
0.019904418,
0.005245616,
0.011063122,
0.015999787,
0.02950166,
0.018142732,
0.0067443633,
-0.005495407,
-0.02653046,
-0.00015683849,
0.011694174,
0.011595572,
-0.029080959,
-0.0019375255,
-0.021021904,
-0.004811768,
-0.03239398,
0.003340958,
-0.008249684,
0.0030139284,
-0.0063466695,
-0.013225789,
-0.009215982,
-0.006882406,
-0.0014658802,
0.01220033,
-0.0048183417,
-0.013554461,
-0.008124789,
0.006471565,
-0.00816423,
-0.01402775,
-0.016985804,
0.01364649,
-0.03447119,
0.000057158235,
0.031605165,
0.0004243986,
0.01166788,
0.010668715,
0.0013031872,
0.016394194,
0.018734343,
0.009492068,
-0.027266687,
0.0005985951,
-0.01653881,
0.0136859305,
0.0019210918,
0.010162559,
-0.013160055,
-0.01513209,
0.022836179,
-0.030343063,
-0.015539644,
0.009137101,
0.001417401,
-0.013804253,
-0.009202835,
0.022757297,
0.031473696,
-0.015999787,
-0.021705544,
-0.033813845,
-0.018839518,
-0.018155878,
-0.03349832,
-0.0013607049,
-0.031868104,
-0.006596461,
-0.007690941,
0.0013360545,
-0.036706164,
0.0056235897,
-0.015539644,
-0.0021593797,
-0.002157736,
0.013791106,
0.011358928,
0.0014009674,
0.011444383,
0.018011263,
-0.01640734,
-0.0327358,
-0.024374366,
0.028239558,
0.0077435286,
-0.019483717,
0.0013582399,
-0.011970259,
-0.03515483,
-0.020929877,
-0.015736848,
-0.01254215,
0.014724537,
0.0049892515,
-0.01294313,
-0.034786716,
0.0024995557,
-0.0041905767,
0.02171869,
0.0044206474,
0.0033853287,
-0.016867483,
0.0033146641,
-0.0036614137,
-0.022612682,
0.019799242,
-0.038126033,
-0.0015176461,
0.027266687,
0.0023927372,
0.028791727,
-0.0021100787,
0.0023532964,
-0.022126244,
0.004131416,
-0.011575852,
-0.035049655,
0.007973599,
-0.026859133,
0.04425249,
0.037468687,
0.03736351,
-0.0053277845,
0.00782241,
0.0016688355,
0.022533799,
0.016052375,
0.007520031,
0.025439266,
-0.01887896,
-0.025005419,
-0.016814895,
-0.0023122123,
0.018221613,
-0.03276209,
0.014303835,
0.026122905,
-0.02632011,
-0.024965977,
0.0038290368,
-0.03362979,
-0.017932381,
0.022191979,
-0.0058799544,
0.023033382,
-0.03426084,
0.0033951888,
0.035444062,
0.020811554,
0.00581422,
0.018892106,
0.021639809,
-0.0025373532,
0.022770444,
-0.007605486,
0.017892942,
-0.017498534,
-0.033866435,
0.00930801,
-0.0066096075,
0.026083464,
0.017104127,
-0.0026803256,
-0.0025176327,
-0.0009827313,
0.010859345,
0.012410681,
-0.02576794,
-0.024492688,
-0.007894718,
-0.027608506,
-0.019247072,
0.002341793,
-0.016617691,
-0.0043056123,
0.00064091175,
-0.009031925,
-0.021061346,
0.009123954,
-0.034918185,
-0.015184678,
0.0068298182,
-0.0036548402,
0.009123954,
-0.0101428395,
0.0038914846,
0.025110593,
-0.005225896,
-0.017064685,
-0.015184678,
0.016683426,
-0.022178832,
0.027371861,
0.020219944,
-0.0020558476,
-0.016630838,
0.017945528,
-0.007040169,
0.0024157444,
-0.03652211,
-0.0031552578,
0.013061453,
0.00892675,
0.0014856005,
-0.01802441,
-0.01653881,
0.0011380292,
-0.018760636,
-0.00090877997,
-0.024045695,
-0.0064649917,
-0.02588626,
0.017814059,
-0.028108088,
0.010681862,
-0.0077106613,
-0.026109759,
0.002080498,
-0.03234139,
-0.0038947712,
-0.0019933998,
0.005163448,
0.021626662,
0.022612682,
0.0048840763,
0.0006129746,
-0.012364667,
0.0103926305,
0.0077303816,
-0.028923197,
0.046014175,
-0.01547391,
0.00047000195,
0.004647432,
-0.005863521,
-0.014487892,
-0.0056005823,
-0.0028019347,
0.010510952,
-0.038257502,
-0.009590669,
0.02742445,
0.01667028,
-0.022888767,
0.020680085,
-0.03349832,
-0.01419866,
-0.015592232,
-0.028896902,
0.01568426,
-0.030868938,
0.019181337,
-0.00528177,
0.0014519116,
0.009446053,
0.00042891785,
-0.00043343712,
-0.0032226357,
0.016762307,
-0.033945315,
0.023717022,
-0.0006425551,
0.029212428,
0.008045907,
-0.0055184145,
-0.011635013,
-0.025176328,
-0.0005579219,
-0.007329401,
-0.05377085,
-0.008920177,
-0.0026704655,
-0.0047361734,
0.0003338082,
-0.010773891,
0.017814059,
0.03557553,
0.027608506,
-0.0026984029,
-0.0276348,
0.008847869,
-0.009301437,
-0.01111571,
0.03136852,
-0.0012325225,
0.0025784373,
0.014448451,
0.0053639384,
0.01632846,
0.00019874427,
-0.0050812797,
-0.041675698,
-0.00004514114,
-0.026201786,
0.00837458,
-0.016473075,
0.011385222,
-0.014382717,
0.011805923,
0.02057491,
-0.0020394141,
-0.025373532,
0.022875618,
-0.010990814,
0.034024198,
-0.017787766,
-0.004969531,
0.0053573647,
-0.0074411496,
-0.028870609,
-0.002767424,
-0.03336685,
0.04264857,
-0.0031799083,
0.0056038694,
-0.019588891,
0.020075327,
-0.04982678,
-0.015802583,
0.005968696,
0.022073658,
0.0050944267,
0.0023993107,
0.0013368762,
0.016275872,
-0.00854549,
0.014040898,
-0.013764812,
-0.023322614,
-0.0035332313,
-0.0025110594,
0.010484659,
0.0059391153,
-0.031210758,
-0.03136852,
0.02992236,
-0.0094131855,
-0.0028775295,
0.005607156,
-0.004039387,
0.050194893,
-0.016762307,
0.021416312,
-0.019825537,
-0.0036909943,
0.016525663,
-0.014356423,
0.002478192,
0.0066227545,
-0.008473182,
0.00048931147,
-0.0147902705,
-0.0005176595,
-0.0018126299,
0.0058996747,
-0.008341713,
-0.027818857,
-0.0016745874,
-0.041386466,
0.0208247,
0.015947198,
-0.010103398,
-0.0019868263,
-0.018589728,
-0.0008718043,
-0.016210137,
-0.012581591,
0.026044024,
0.018931547,
-0.007171638,
-0.00364498,
-0.024124576,
0.0151189435,
0.0105438195,
-0.019457422,
-0.008828148,
-0.010215147,
0.011786203,
-0.058056742,
0.00982074,
0.0077106613,
-0.009202835,
0.005666317,
-0.0035200845,
-0.019957006,
-0.011904525,
0.010957947,
0.0018570006,
-0.0059752692,
-0.020929877,
0.006152753,
-0.01513209,
-0.005137154,
0.011312914,
-0.008197097,
-0.031079289,
0.003898058,
0.17227708,
-0.017077833,
-0.0068889796,
0.014671949,
-0.0025948707,
-0.0010837981,
-0.0029038233,
-0.022126244,
-0.031237053,
0.0054198126,
0.00982074,
-0.007914438,
-0.013804253,
0.006139606,
-0.0039867996,
0.0011939035,
-0.036706164,
-0.010136265,
-0.014343276,
-0.011740188,
0.03081635,
-0.007921012,
0.012358093,
-0.0022136106,
0.041439053,
0.008243111,
-0.00058955664,
0.022862472,
0.02695116,
0.0030911667,
-0.03838897,
0.014132925,
0.009584095,
-0.005015545,
0.00069760776,
0.012384387,
-0.029738305,
-0.0031486843,
0.014632508,
-0.011595572,
-0.008190523,
0.0033491747,
-0.021955336,
-0.008282552,
-0.0035332313,
0.01819532,
0.00056161947,
-0.026267521,
-0.020719526,
-0.0113720745,
-0.035181124,
-0.0147902705,
0.01798497,
0.019010428,
0.016473075,
-0.0038586173,
0.021495193,
0.007953879,
-0.00040693788,
0.02291506,
-0.007940732,
-0.0016482936,
-0.023756461,
0.039046314,
-0.011943965,
0.017866647,
-0.015237265,
-0.016657133,
0.00073006423,
-0.030553414,
-0.007769822,
-0.014632508,
-0.0063039423,
-0.009590669,
-0.01075417,
-0.019141898,
0.015697407,
0.0034707836,
-0.0015710554,
-0.000073078314,
0.007414856,
0.023532964,
-0.0276348,
-0.0069875815,
-0.004654005,
-0.029869774,
0.025951995,
0.0015217545,
-0.02643843,
-0.0074674436,
0.008676959,
0.004091975,
-0.023769608,
0.0028265852,
0.007605486,
-0.024111427,
-0.007999893,
-0.0064551313,
0.008111642,
-0.031052995,
-0.023703875,
0.09092401,
0.022507505,
0.016473075,
-0.010188853,
0.017353918,
0.0022957786,
-0.006823245,
0.005909535,
-0.015289853,
0.0032094887,
-0.03468154,
0.008696679,
-0.004680299,
0.0057254783,
0.02240233,
-0.0002506129,
-0.01056354,
-0.0058733807,
0.0074477233,
0.019076163,
-0.03418196,
-0.003503651,
0.0035693853,
-0.029738305,
0.023270026,
-0.02797662,
0.017275037,
-0.0085586365,
-0.030211594,
-0.007566045,
-0.006448558,
0.010294029,
0.023217438,
0.010044238,
-0.024584716,
0.008782134,
-0.0174328,
0.00038495788,
0.009570949,
-0.008177376,
0.017196154,
0.0036844208,
-0.00930801,
0.017183008,
0.00039728312,
0.017630003,
0.011109137,
-0.0033984755,
-0.013896281,
-0.0022842751,
-0.010221721,
-0.010635848,
-0.009708991,
0.021547781,
0.00073047506,
0.00014430785,
-0.018970987,
0.001639255,
0.017235596,
-0.019523157,
0.04259598,
0.010570114,
0.0034346296,
-0.015224119,
-0.0063400962,
-0.16344236,
0.024006253,
0.018116439,
-0.018418817,
0.01326523,
0.008808428,
0.0062677884,
0.009314584,
0.007848703,
0.018261055,
0.043647733,
-0.0025127027,
-0.023427788,
0.0071387705,
0.007921012,
-0.019339101,
-0.024795067,
0.0433585,
0.025649616,
0.035601825,
0.019141898,
-0.01972036,
0.009853607,
-0.028134381,
0.00963011,
0.02185016,
0.02491339,
-0.0025357099,
-0.012667045,
-0.01260131,
-0.022178832,
0.007388562,
0.044278786,
-0.010806758,
0.012016273,
-0.014501039,
-0.0005205354,
-0.021758132,
0.0062776483,
0.031026702,
0.041465346,
0.006823245,
0.026385844,
0.00083606114,
-0.018760636,
0.03165775,
0.003178265,
-0.015618526,
0.015920905,
0.002473262,
0.017630003,
0.012450121,
0.010057384,
0.01610496,
0.015868317,
0.014461598,
0.006379537,
0.020969318,
-0.01832679,
-0.00026211646,
-0.0068758326,
-0.026333256,
0.032972444,
0.010083678,
0.0134098455,
-0.023388349,
0.0032209924,
0.0043483395,
0.018234761,
0.019325955,
-0.03192069,
0.0041577094,
0.02432178,
-0.012154316,
0.015210972,
-0.0061264588,
-0.021587223,
0.020311972,
-0.0044337944,
0.0072505195,
-0.013291524,
-0.008525769,
-0.012187183,
-0.0068561123,
-0.011792776,
0.0012768934,
0.0057254783,
0.0060837315,
-0.011339208,
-0.0043253326,
0.004042674,
-0.022638975,
-0.0060344306,
-0.013015439,
0.0019572459,
0.031473696,
0.005741912,
-0.010609554,
0.014645655,
0.0076580737,
0.009077939,
-0.026688222,
-0.013422992,
-0.01581573,
-0.0023845204,
-0.010977668,
-0.039256666,
-0.017380212,
0.028686551,
-0.008446888,
-0.008854442,
0.027214099,
0.004042674,
0.018944694,
-0.0022481212,
0.0120097,
0.0011708965,
0.00493009,
0.024821362,
-0.028081795,
0.06373621,
0.0023582266,
0.012016273,
0.01747224,
-0.014277541,
-0.008414021,
-0.13210012,
-0.02601773,
0.020627499,
-0.0043417662,
-0.029475367,
0.002875886,
-0.012496135,
0.013896281,
-0.032131042,
0.0145141855,
-0.015381882,
0.008144509,
-0.003766589,
-0.022047363,
0.0028972498,
0.009741859,
0.00654716,
-0.013567609,
-0.019220779,
0.027950326,
-0.0036515535,
-0.015000622,
0.004861069,
-0.008210244,
0.003156901,
0.016591398,
-0.026083464,
0.012634178,
0.0049826778,
0.02133743,
-0.013541315,
0.021008758,
0.0399666,
-0.0070598894,
-0.008295699,
0.000055668937,
-0.015381882,
-0.022494359,
0.036495816,
-0.0147902705,
-0.002948194,
0.0009917698,
0.0028200117,
0.009202835,
-0.008841295,
-0.01385684,
-0.024611011,
-0.0042990386,
0.024558423,
-0.022849325,
-0.019457422,
-0.038126033,
-0.03610141,
-0.018471405,
0.00007559472,
-0.008137936,
0.004371347,
0.028134381,
0.014474745,
-0.0054493933,
0.028633965,
-0.0037567287,
-0.0032702931,
0.024269192,
0.02678025,
-0.014987474,
0.017209303,
-0.029738305,
0.020141061,
-0.032709505,
0.010261161,
-0.017945528,
-0.015973493,
-0.02133743,
-0.0008455105,
0.023743315,
-0.017761473,
-0.024505835,
0.013173201,
-0.024611011,
-0.009853607,
-0.0066950624,
0.029475367,
0.0070598894,
0.039519604,
0.00058791327,
0.022034217,
-0.0034839304,
0.01204914,
-0.012975997,
-0.01475083,
0.047197398,
0.010340042,
0.0060968786,
-0.0049169436,
0.014698243,
0.0009227486,
0.0063236626,
0.01239096,
0.022836179,
-0.006882406,
-0.019536305,
-0.048669852,
0.025058005,
-0.01653881,
0.011319487,
0.005587436,
-0.009117381,
0.0013516664,
-0.022770444,
0.012279212,
0.0079801725,
-0.0068889796,
0.01220033,
-0.013350684,
0.010629275,
-0.039309252,
-0.017616857,
0.008289125,
-0.010984241,
0.018813225,
0.01947057,
0.0058306535,
0.008690106,
0.00015242196,
0.034234546,
0.015355588,
0.00032045587,
-0.0019276653,
0.03039565,
0.007907865,
-0.0098404605,
0.01398831,
-0.017892942,
-0.011142004,
0.0034970774,
-0.01853714,
-0.016262725,
0.013403272,
0.039309252,
0.017261889,
0.027792562,
0.0013804253,
-0.043516263,
0.010576687,
-0.007592339,
-0.009235702,
-0.024164015,
-0.06431467,
0.015197825,
0.011536411,
-0.02457157,
0.018563433,
0.031342227,
-0.013252082,
-0.032315098,
-0.0214689,
0.008170803,
0.0023319328,
-0.022086805,
-0.006882406,
-0.014606214,
0.00109448,
0.015539644,
0.004259598,
-0.004391067,
-0.019904418,
-0.029606836,
-0.031105584,
0.012384387,
-0.013199495,
0.0064682784,
-0.022717856,
0.02984348,
-0.0017008812,
0.0030944534,
0.02860767,
0.0011758265,
-0.011023682,
0.016144402,
-0.010090251,
0.02742445,
0.0008980981,
-0.024006253,
-0.032630626,
0.025728498,
0.042148985,
-0.0058076466,
-0.016210137,
0.010491232,
0.015828876,
-0.0056465967,
-0.014882299,
0.014711389,
-0.007973599,
0.031762928,
-0.0018372803,
0.023191145,
0.025781086,
0.0128050875,
-0.004647432,
0.05319239,
0.02223142,
-0.014132925,
-0.01001137,
-0.029028371,
0.0036186862,
0.024413807,
-0.039046314,
-0.034550074,
-0.032840975,
-0.006954714,
0.019930711,
0.012719633,
0.011635013,
-0.009794446,
-0.036232878,
0.006701636,
-0.021035053,
0.016091814,
-0.018576581,
0.012384387,
0.0032472862,
0.018944694,
-0.0025603601,
-0.0065175793,
-0.0064551313,
0.0014519116,
0.004522536,
-0.024624158,
0.016946364,
-0.0024847656,
0.02240233,
0.0005788748,
-0.040413592,
-0.015789436,
-0.019654626,
-0.026280668,
0.011358928,
0.032972444,
-0.027582211,
0.05831968,
0.007013875,
-0.004042674,
0.0049037966,
-0.012187183,
0.0077895424,
-0.0034444898,
0.025281504,
-0.0027509904,
-0.0065175793,
0.04343738,
0.0026030876,
0.021035053,
-0.030606,
-0.03907261,
0.02609661,
-0.008361433,
-0.0043187593,
0.0021199388,
-0.009603816,
0.010320323,
-0.016736014,
0.004404214,
-0.016381046,
-0.03026418,
-0.01309432,
0.02388793,
0.013317817,
-0.0050977133,
-0.032578036,
0.00782241,
-0.006701636,
-0.047381453,
0.0012645682,
0.013869988,
-0.03494448,
-0.012910263,
-0.008381153,
0.0057254783,
-0.0059259688,
0.008190523,
0.04433137,
-0.032709505,
-0.0063598165,
0.0019424555,
-0.03047453,
-0.020009594,
-0.030684883,
-0.0132586565
] |
Objective. Chemotherapeutic agents function by inducing apoptosis and their effectiveness depends on the balance of pro- and anti-apoptotic proteins in cells. Due to the complicated interactions of the many proteins involved, it has been difficult to determine in tumors whether overexpression of single genes is prognostic for increased resistance. Therefore, we studied the influence of bcl-2 overexpression on resistance to chemotherapeutics in a transgenic mouse system. This allowed us to study a wide variety of cells, including important but rare populations such as hematopoietic stem cells (HSC).Methods. H2K-bcl-2 transgenic and | [
-0.03974384,
-0.0084955795,
-0.010896214,
-0.031261597,
0.010029318,
0.017497959,
0.0028024076,
0.020818837,
-0.016431011,
-0.007435299,
0.011409683,
-0.0021005552,
0.005864884,
0.010876209,
-0.0112896515,
0.00033925637,
0.04297136,
-0.008008784,
-0.013276843,
0.0030191315,
-0.025753476,
0.03600952,
-0.010289387,
-0.00645504,
-0.016991159,
0.0071685617,
0.021792429,
-0.04865286,
-0.0024173057,
-0.0144171445,
-0.001372863,
0.015417409,
-0.03630293,
-0.012750037,
-0.0005613984,
-0.021579038,
0.010749509,
-0.00024027185,
0.016070915,
-0.0067851273,
0.008375548,
0.0042878003,
-0.009069065,
0.020058636,
0.001970521,
-0.017244559,
0.0025790152,
-0.017311243,
-0.015404073,
-0.0030007933,
0.0076486887,
0.013776976,
-0.022099176,
-0.00059265667,
-0.0060449312,
-0.020432068,
0.006508387,
0.035316,
0.011416351,
-0.02241926,
0.009015717,
0.0010827862,
-0.0200453,
0.017711349,
-0.008595605,
-0.0060616024,
-0.013710291,
0.007108546,
0.017031169,
0.013283512,
0.042704623,
0.029394438,
0.00057098427,
0.011829794,
0.016217621,
-0.00651839,
-0.050680064,
0.017124528,
0.004794601,
0.0015729158,
0.0276073,
-0.0113163255,
0.01779137,
0.0026256943,
0.021245617,
0.007755384,
-0.02539338,
0.008955701,
0.0015028974,
-0.008168826,
0.024299758,
0.014297113,
0.01907171,
0.015003967,
-0.0087023005,
0.016310979,
0.010762845,
0.03715649,
0.013963692,
-0.02891431,
0.010916219,
0.0072685885,
-0.008122147,
-0.02237925,
-0.0079421,
0.005801534,
0.011756442,
0.0037176495,
0.015083988,
-0.009549191,
-0.02840751,
0.03720984,
-0.005478115,
-0.035742782,
0.030007934,
-0.0115230465,
0.006751785,
-0.009022385,
-0.00673178,
-0.0019171735,
0.0120898625,
0.015564115,
0.030808145,
-0.0400906,
0.014750566,
0.011776446,
-0.017257895,
-0.011042919,
-0.0066484245,
0.010296055,
0.016484357,
0.025086632,
0.012923417,
-0.0044145,
-0.010249376,
0.0031124896,
-0.0087023005,
-0.02199248,
-0.014283776,
-0.02267266,
0.018338181,
0.030728124,
0.021365648,
0.005478115,
-0.019311773,
0.0013053451,
0.028940985,
0.03019465,
-0.02140566,
0.020218678,
-0.008228842,
-0.014403808,
0.011923152,
-0.016524369,
0.0058448785,
0.00235729,
-0.0027523944,
0.012856732,
-0.030834818,
-0.025246674,
0.01991193,
-0.008208836,
0.023259483,
0.021112248,
0.027500603,
0.02926107,
0.005948239,
0.019231752,
0.004037734,
-0.0027740668,
0.015230693,
0.01961852,
-0.021459006,
0.016124263,
-0.013050117,
-0.00028945153,
0.006355013,
0.015337388,
-0.01672442,
-0.0046845716,
-0.031368293,
0.033022065,
0.0074419673,
0.007215241,
-0.011062925,
0.011789784,
0.017257895,
-0.025566759,
0.0014187084,
-0.03158168,
0.005898226,
0.020205341,
-0.010069328,
-0.011949826,
-0.6260855,
-0.033608884,
-0.0102293715,
-0.014590524,
0.0050813435,
0.027153846,
0.040037252,
-0.0042311186,
-0.033528864,
0.031288274,
-0.019631857,
0.02220587,
0.009449164,
-0.039157018,
-0.009835933,
-0.049399726,
-0.0056448258,
-0.029421112,
0.03299539,
-0.008808996,
-0.013636938,
-0.012203226,
-0.04603884,
0.029367764,
-0.0075686676,
0.029954586,
0.027167182,
-0.0063383426,
-0.014177081,
0.04390494,
-0.014577188,
0.034622487,
-0.015510768,
-0.0096092075,
0.053267416,
0.014390471,
0.0037043127,
0.010216034,
0.034729183,
0.028567553,
0.004871288,
0.0008585603,
0.023166124,
0.00025277515,
-0.021098912,
0.014230429,
0.016577717,
0.0042344527,
0.00075603323,
0.0080821365,
0.0033558873,
0.022619313,
-0.03520931,
-0.0003876025,
-0.010562792,
0.0102026975,
0.010336066,
-0.034089014,
0.02798073,
-0.011663083,
-0.0043244767,
0.010309393,
-0.013316854,
-0.022966072,
-0.01757798,
0.012483301,
-0.025940191,
-0.01473723,
-0.0023039423,
0.025940191,
0.025033284,
0.012043184,
-0.008588937,
0.015470757,
0.019498488,
0.03334215,
0.0052880645,
0.0006860147,
0.01129632,
0.030728124,
0.014137071,
-0.016897801,
-0.046732355,
-0.00047595915,
0.02335284,
0.011869805,
-0.007915426,
0.02047208,
0.013190154,
0.00012867985,
0.00989595,
0.0210589,
-0.017631328,
-0.034089014,
-0.0054881177,
0.013776976,
0.004181105,
0.015937546,
0.015937546,
-0.03256861,
-0.026620371,
-0.027447257,
0.019365119,
0.010976235,
-0.011963163,
0.002093887,
-0.0104094185,
0.0029841224,
0.03715649,
-0.0048812907,
-0.011356336,
0.00063308404,
0.0042777974,
-0.019671867,
0.0121432105,
-0.016497696,
0.023619577,
0.005104683,
0.0028640905,
-0.04225117,
0.017417938,
-0.006208308,
-0.008802327,
-0.006378353,
0.017164538,
-0.00017223303,
0.014457155,
-0.017177874,
0.007815399,
-0.008782322,
0.009749244,
-0.019285098,
0.008202168,
-0.02399301,
0.017964749,
-0.029954586,
0.020432068,
0.01146303,
0.012316589,
-0.02169907,
-0.02441979,
0.0026907113,
0.0121698845,
0.021632386,
-0.014630535,
-0.0020605447,
-0.012369937,
-0.021365648,
0.012630005,
0.012449958,
0.0064317,
0.009909286,
0.0057748603,
0.0016671075,
0.04574543,
-0.014670545,
-0.0129700955,
-0.0038910287,
-0.011449694,
-0.028434183,
0.00033988152,
-0.0016162606,
0.01753797,
0.0023422858,
-0.023112778,
-0.016364327,
0.010789519,
0.017604655,
-0.0070151878,
-0.03184842,
-0.0015612461,
-0.019965278,
-0.014510503,
0.009509181,
0.0050546695,
0.0059682447,
-0.013236833,
0.0034809203,
0.0019671868,
-0.00976925,
0.011556389,
-0.017084517,
-0.015577451,
-0.004814606,
0.033662234,
0.01915173,
0.035316,
0.00020672132,
-0.006611748,
0.03342217,
-0.013210159,
0.024353106,
-0.011576394,
0.02348621,
-0.0050179935,
-0.03070145,
0.011349667,
0.018538235,
0.030381365,
0.04441174,
0.012796717,
-0.007762052,
0.0045445347,
-0.029367764,
0.013143475,
-0.02292606,
0.0016129264,
0.00009820305,
-0.005171367,
0.009715902,
-0.006198305,
0.0036576337,
-0.018538235,
-0.01757798,
0.004271129,
0.0030774802,
-0.001568748,
-0.023872979,
0.009109075,
-0.033048738,
-0.0016612725,
-0.010849535,
0.007108546,
-0.0024556492,
-0.014817251,
0.011483036,
0.02259264,
0.022979409,
-0.007188567,
0.008115479,
-0.0032041804,
0.008248848,
0.0045245294,
-0.009949297,
0.031288274,
-0.008688964,
0.017738022,
0.004204445,
0.03120825,
-0.0012353266,
-0.019018361,
0.0103827445,
-0.005414765,
0.020192005,
0.0005889057,
0.0049413065,
0.02097888,
0.015564115,
-0.011956494,
0.0070952093,
-0.0055981465,
0.005491452,
-0.014803913,
0.0024106372,
0.005124688,
-0.012770043,
0.008735643,
0.021859113,
0.06182968,
0.026807087,
0.017257895,
-0.017871391,
0.0017738023,
-0.01142302,
0.0017704681,
0.00692183,
0.006488382,
0.0127633745,
0.0049746484,
-0.00065975776,
-0.021125585,
-0.0069951825,
0.024726538,
-0.017711349,
0.022539292,
0.03307541,
0.0014112064,
0.028594226,
0.0066517587,
0.0074819783,
-0.022499282,
-0.018818308,
0.021005554,
0.023979673,
-0.0077887257,
0.0019671868,
-0.02739391,
-0.005878221,
-0.007295262,
0.014617198,
0.0075553306,
0.00055848097,
0.011476368,
0.013043448,
-0.006908493,
-0.010422756,
0.009635881,
-0.013123469,
0.0028507537,
-0.011629742,
0.01779137,
-0.0021322304,
-0.016777769,
-0.0014037044,
0.051000148,
0.009729239,
-0.0028740931,
-0.02611357,
-0.0051313564,
-0.027500603,
-0.00091024063,
0.00021901623,
-0.0014170413,
-0.017591318,
0.004947975,
0.00751532,
0.0121165365,
0.02220587,
0.011269646,
-0.0022139186,
-0.024153052,
-0.028114099,
0.0067584533,
0.002203916,
0.015684146,
0.017911403,
-0.005724847,
0.008995712,
-0.00097192364,
0.030087955,
0.0016929476,
-0.013670281,
0.00959587,
-0.029421112,
-0.004341148,
0.0051580304,
-0.00564816,
-0.011656415,
-0.0068551456,
0.01872495,
-0.009569197,
-0.028860964,
0.0065383953,
0.0019155064,
-0.008288858,
-0.0055214595,
0.03571611,
0.028860964,
0.0144438185,
0.015870862,
0.004801269,
0.019711878,
0.007201904,
0.004971314,
-0.007928763,
0.00651839,
0.013310186,
0.012509974,
-0.003012463,
-0.022819366,
0.00018932088,
0.014790577,
0.0025540085,
-0.009709233,
0.02646033,
0.017778033,
0.0033108753,
-0.015550778,
-0.02840751,
-0.020071974,
0.003490923,
0.010862872,
-0.0054114307,
-0.029367764,
-0.00785541,
-0.012890074,
-0.027273877,
-0.022472607,
-0.004814606,
0.009715902,
-0.0042744633,
-0.001877163,
0.0019338446,
-0.0032858688,
-0.00049137993,
-0.03006128,
0.01711119,
-0.011723099,
0.011843131,
-0.009182428,
-0.028274141,
-0.029901238,
-0.014630535,
-0.032968715,
0.019711878,
-0.019645194,
-0.032808673,
0.017004495,
0.03771664,
-0.0015154006,
0.0012678351,
-0.021138921,
-0.009622544,
0.025206665,
-0.0067784586,
-0.029527806,
0.0076486887,
-0.0540943,
0.023286156,
-0.011222967,
-0.006748451,
-0.013110133,
-0.011149614,
0.01163641,
-0.013323522,
-0.038063396,
0.0077687204,
0.00006965383,
0.0031641698,
-0.0009360808,
0.008248848,
0.026513677,
0.02101889,
-0.011069593,
0.0120898625,
-0.009182428,
-0.022259219,
-0.029394438,
-0.011216299,
-0.022685997,
-0.0069418354,
-0.0019455143,
-0.011849799,
-0.008515584,
0.013510238,
-0.004347816,
0.0024306425,
-0.024033021,
-0.004731251,
0.019818572,
-0.008588937,
0.03982386,
0.011389677,
-0.00069726765,
0.0057748603,
-0.013150143,
0.01893834,
0.012383274,
-0.011716431,
-0.023699598,
0.008882348,
-0.032248527,
-0.011136278,
-0.006755119,
-0.025059959,
0.015043978,
0.0057981997,
-0.0104627665,
-0.025019947,
-0.011876473,
-0.020858848,
0.008969038,
0.006975177,
-0.02191246,
-0.013123469,
0.013310186,
0.007828737,
-0.024633178,
0.012670016,
-0.035476044,
-0.012603332,
0.0195385,
0.011476368,
-0.017884728,
0.0074086254,
-0.0067951297,
-0.04305138,
-0.012483301,
-0.022565966,
-0.044171676,
0.012149879,
-0.017311243,
0.039343733,
0.053187396,
0.032088485,
0.004177771,
0.031901766,
0.016270969,
0.009242443,
0.028274141,
-0.0041611,
0.018484887,
-0.015137335,
0.019458478,
-0.01868494,
-0.010389414,
0.014897272,
-0.020885522,
0.019831909,
-0.00054931187,
0.0057181786,
-0.0015754165,
0.0028340826,
-0.027193855,
-0.022512618,
0.02327282,
-0.011836463,
0.0031991792,
-0.026687056,
0.003382561,
0.028034078,
-0.00016129264,
0.002403969,
0.02152569,
0.01825816,
-0.0023722937,
-0.0040677423,
-0.0006172465,
-0.015177346,
-0.0015087322,
-0.004487853,
0.005604815,
-0.0024973268,
0.0057048416,
-0.003339216,
0.013696955,
-0.010929557,
-0.031368293,
-0.005958242,
0.010936225,
-0.0114696985,
-0.009535855,
0.0038510181,
-0.004884625,
-0.023192799,
-0.0026757075,
0.0057648574,
-0.013383538,
0.010936225,
0.028487531,
-0.004484519,
0.015230693,
0.0013436886,
-0.0072352462,
0.028380837,
-0.017311243,
0.01673776,
-0.022045828,
0.023046093,
0.026820423,
0.0008185497,
-0.0012528312,
-0.020778827,
-0.008448901,
0.016991159,
0.012676685,
0.036676362,
-0.012856732,
-0.0035742782,
-0.008869011,
0.0026456995,
-0.02237925,
-0.016124263,
0.016884463,
-0.021632386,
0.0064483713,
-0.024193063,
-0.020445405,
-0.030754797,
0.002048875,
-0.011309656,
0.0067951297,
0.0039310395,
-0.023472872,
-0.009269117,
0.003877692,
-0.0063150027,
-0.011449694,
0.023379514,
-0.016884463,
-0.01919174,
-0.022219207,
0.0026206928,
-0.012876738,
-0.018444877,
0.04089081,
0.007575336,
0.013216828,
0.023099441,
0.00571151,
-0.0020055303,
-0.021805765,
-0.011309656,
0.0421178,
-0.0064817136,
-0.0017087851,
0.0011144613,
-0.011569725,
0.0030324683,
-0.009249112,
-0.012209895,
-0.031528335,
-0.04131759,
0.0015654139,
0.032221854,
0.030568082,
-0.00015785423,
-0.0023856307,
-0.02560677,
-0.0070151878,
-0.021032227,
-0.024153052,
0.0068484773,
-0.03881026,
-0.005804868,
-0.018164802,
-0.002670706,
0.033395495,
0.013303517,
0.0033408832,
0.0009360808,
0.040997505,
-0.028060751,
0.017778033,
-0.00029945417,
-0.010049324,
-0.026406981,
0.01907171,
-0.033102084,
-0.019085046,
-0.0089890435,
-0.013210159,
-0.037396554,
-0.044331722,
-0.03656967,
0.012750037,
0.037930027,
-0.019391794,
0.010256045,
0.01337687,
0.01813813,
-0.01707118,
-0.0046178875,
0.009709233,
-0.02097888,
0.026180254,
0.015083988,
-0.019698542,
-0.022952735,
-0.015577451,
-0.0023422858,
-0.0095291855,
0.0017654668,
-0.02373961,
-0.009149086,
0.0051313564,
0.01961852,
0.0050079906,
-0.023672925,
-0.0010411086,
-0.015444083,
0.017124528,
0.013910344,
-0.007375283,
-0.023979673,
-0.0015137335,
-0.016337652,
-0.00039114506,
-0.02739391,
-0.00450119,
-0.017177874,
-0.028834289,
-0.044011634,
0.0008256349,
-0.01647102,
0.03507594,
0.008642285,
-0.014337123,
-0.012603332,
-0.01635099,
-0.035662763,
0.0052047092,
-0.003010796,
0.018111454,
-0.0129700955,
0.032088485,
-0.021859113,
-0.0017988089,
0.0019771894,
0.00015045644,
0.015150672,
-0.021979144,
0.006281661,
-0.023086103,
0.015910873,
0.01239661,
-0.037529923,
-0.030674776,
0.041397613,
-0.027367236,
-0.030461386,
0.031368293,
-0.011989837,
0.024273084,
-0.018884992,
0.004901296,
0.0066817664,
0.010196029,
0.012850064,
-0.027874036,
-0.0052980673,
0.016310979,
-0.002947446,
-0.0036109546,
0.00066725974,
0.008902353,
-0.0040077264,
-0.018804971,
-0.014203755,
-0.03235522,
-0.0052280487,
0.008575601,
-0.010629477,
0.020445405,
0.0080821365,
0.014483829,
0.0031708383,
-0.009569197,
-0.007835405,
-0.00518137,
0.0064050267,
-0.0034209045,
-0.0052547227,
0.0089623695,
-0.012896743,
-0.012283247,
0.0051413593,
-0.015617462,
0.011549721,
-0.007448636,
-0.003210849,
-0.029421112,
0.015657473,
0.022565966,
-0.008455569,
-0.025620107,
-0.0069418354,
-0.02385964,
-0.024499811,
-0.0035042597,
-0.013570255,
-0.008422227,
0.00033237954,
-0.0003475919,
0.008422227,
0.0014320452,
-0.027527278,
-0.0153240515,
-0.017484622,
0.013816986,
0.19450475,
-0.028834289,
0.00024881578,
-0.0016971154,
0.0044678478,
-0.011696425,
0.0026823757,
-0.006274992,
0.007448636,
0.009089069,
0.018458214,
0.011383009,
-0.0026190258,
-0.001178645,
0.020445405,
-0.0049446407,
-0.013683618,
0.00011180039,
-0.013083459,
0.0056915046,
-0.008488911,
-0.010422756,
0.03456914,
-0.0063383426,
0.026500339,
0.009409154,
-0.011896478,
0.02539338,
0.020192005,
-0.0074553043,
-0.030754797,
-0.0015787507,
0.0048212744,
0.0013920347,
0.004727917,
0.0039143683,
-0.012803385,
-0.009922624,
-0.005351415,
-0.036836404,
-0.012003173,
0.020392058,
-0.007955437,
0.010069328,
0.019205077,
0.017031169,
0.008042126,
-0.0061382893,
-0.0005980748,
0.0057681915,
-0.03307541,
0.010989572,
0.018098118,
0.033742253,
-0.011276315,
0.013470228,
0.020525426,
-0.021885786,
-0.0065383953,
0.033608884,
-0.023152787,
-0.012843396,
-0.042624604,
0.027633972,
0.013196822,
0.027847363,
-0.0016854455,
0.013410212,
0.009229107,
-0.020165332,
0.004561206,
-0.0051313564,
-0.020952206,
0.007215241,
0.01452384,
-0.008402221,
-0.006608414,
0.014857261,
0.01885832,
0.015350725,
0.008102142,
0.004127758,
-0.034729183,
0.0066851005,
-0.030354692,
-0.02500661,
0.023006082,
0.009982639,
-0.0072285775,
-0.0059949183,
0.0008960702,
0.010542788,
-0.015097325,
-0.0014378801,
0.015577451,
-0.0051280223,
-0.009749244,
0.020778827,
-0.02564678,
-0.014617198,
-0.04275797,
0.08882348,
-0.015057314,
0.017564643,
-0.0030191315,
-0.00089773734,
-0.014577188,
0.014537177,
-0.011116272,
-0.000021854736,
0.035902824,
-0.019591846,
-0.0064483713,
-0.011489704,
0.00067101076,
0.033102084,
-0.007375283,
0.0048346114,
0.026513677,
-0.021539027,
-0.009435828,
-0.03435575,
-0.0009044058,
0.039530452,
-0.008929027,
0.0114963725,
-0.020712143,
0.008675627,
-0.017698012,
-0.020418731,
0.0080688,
0.014283776,
-0.013470228,
0.021605711,
0.018991688,
0.0050179935,
0.0022339239,
0.0033725584,
-0.028460858,
0.022219207,
-0.028300816,
-0.0119098155,
-0.0131768165,
0.02033871,
0.006211642,
-0.024219736,
0.015470757,
-0.0046045505,
0.0010369408,
-0.021632386,
0.0010436092,
-0.026913783,
-0.025286686,
-0.014083724,
0.022712672,
-0.037930027,
-0.008088805,
-0.019578509,
0.026366971,
0.0073352726,
-0.017297907,
0.02934109,
0.013216828,
-0.015310714,
-0.012276579,
-0.018431539,
-0.16729756,
0.0003132078,
0.023646252,
-0.031368293,
0.03651632,
0.004871288,
-0.00583821,
-0.022005817,
-0.015177346,
0.024379779,
0.013296849,
0.000803129,
-0.028514205,
-0.028700922,
0.015964221,
0.00010596551,
0.002140566,
0.04814606,
0.03843683,
-0.0035476047,
0.031501662,
0.010936225,
0.030167976,
-0.0029657842,
0.0040077264,
0.026380308,
0.009335802,
-0.015870862,
0.0024139716,
-0.009175759,
-0.01452384,
0.0014695552,
0.011016246,
-0.0052247145,
0.0008877347,
0.0067784586,
0.0016504363,
0.0069618407,
-0.011916484,
0.012710026,
0.030434713,
0.033768926,
-0.010216034,
-0.001738793,
-0.018191475,
0.03048806,
0.025059959,
0.0017104523,
0.013430217,
0.015057314,
0.03048806,
-0.008588937,
0.022139186,
0.01944514,
0.016804442,
-0.0066350875,
0.009015717,
0.016631063,
-0.0115230465,
0.018031433,
-0.0051513617,
-0.024446463,
0.025580097,
0.0073819514,
-0.006968509,
-0.024059694,
-0.0058548814,
0.017137865,
-0.020178668,
0.00024527317,
-0.024859905,
0.021392323,
0.021045564,
-0.00024381446,
0.017778033,
0.018071445,
0.0016212619,
-0.004637893,
0.009949297,
0.014977293,
-0.0020388723,
0.007968773,
-0.033742253,
-0.020312037,
0.0010619474,
0.005668165,
0.0061816345,
0.014763903,
-0.0045412006,
0.006041597,
-0.00032716984,
-0.011776446,
-0.013190154,
-0.026953792,
0.01635099,
0.023672925,
0.004101084,
-0.012236568,
0.012850064,
-0.0065450636,
0.017684676,
-0.01380365,
-0.008328869,
-0.017764697,
0.025486737,
0.0043978295,
-0.006274992,
-0.0070885406,
0.038463503,
-0.0104627665,
-0.012023179,
-0.0033808937,
0.0017037838,
0.022579303,
-0.0061716316,
0.027713994,
0.022485945,
-0.002482323,
-0.019725215,
-0.02704715,
0.07105879,
0.006411695,
-0.009562528,
0.0322752,
-0.0017487956,
-0.014163745,
-0.12088529,
-0.020738816,
0.008035458,
0.013370201,
-0.0007235246,
0.026780413,
-0.004361153,
0.028220795,
-0.010896214,
0.036889754,
-0.0089890435,
-0.011716431,
-0.014590524,
-0.017311243,
0.016417673,
0.01767134,
0.011229635,
-0.008388884,
0.006598411,
0.03112823,
0.010122676,
0.00003654612,
0.00060599355,
-0.019311773,
0.014657209,
-0.004964646,
-0.02292606,
0.013870333,
0.0036643022,
0.01693781,
0.013776976,
-0.0029891236,
0.014390471,
0.0060082553,
-0.0033792267,
-0.019311773,
-0.00039739674,
-0.044091657,
0.050973475,
-0.018151466,
-0.008375548,
0.019738551,
-0.0072352462,
-0.0018071444,
-0.0058482126,
-0.024153052,
-0.0112896515,
-0.013076791,
0.008568932,
-0.02144567,
-0.028514205,
-0.026620371,
-0.02127229,
0.009075733,
0.022739345,
-0.006908493,
0.019178404,
0.037636615,
-0.021112248,
-0.0017271233,
0.0127633745,
0.00930246,
-0.030648103,
0.0022906056,
0.022659324,
-0.015764168,
-0.015697483,
-0.025473401,
0.02586017,
-0.024939926,
0.00220725,
0.012416616,
-0.012196558,
-0.011042919,
-0.045585386,
-0.013603596,
-0.012976764,
-0.0012853398,
0.020845512,
-0.016364327,
-0.01409706,
-0.012843396,
0.03371558,
-0.017698012,
0.038916957,
-0.022699334,
-0.0011853133,
-0.009015717,
-0.004144429,
-0.009289122,
-0.008208836,
0.039690495,
-0.028647574,
-0.019885257,
-0.0135902595,
-0.008722306,
0.0035776126,
0.0005830708,
0.018791635,
0.014550514,
0.0012094864,
-0.001419542,
-0.04510526,
0.007508652,
-0.0060582682,
-0.0049112984,
0.014363797,
0.0008960702,
-0.0060049207,
-0.006054934,
0.007248583,
0.0079020895,
-0.009942628,
0.00060390966,
-0.013923681,
-0.012596664,
-0.004497856,
0.00087773206,
0.026607035,
-0.02191246,
0.015844189,
0.032461915,
-0.012543316,
-0.03801005,
0.027167182,
-0.0037743312,
-0.014217092,
-0.010349403,
0.002018867,
0.025540086,
-0.0144438185,
0.00751532,
-0.0042978027,
-0.038330134,
-0.026820423,
-0.0066317534,
-0.022685997,
-0.0113163255,
-0.00034488284,
0.030328019,
0.026567023,
0.029741196,
-0.00900238,
-0.031394966,
0.005808202,
-0.008222174,
0.01893834,
-0.0029124366,
-0.036623016,
0.007541994,
0.00228227,
-0.015724158,
0.042064454,
0.0007256085,
0.011256309,
-0.031448316,
-0.024473136,
0.0033325476,
-0.016764432,
-0.022699334,
-0.028860964,
0.0032842015,
0.0034809203,
0.018764962,
-0.009775918,
0.015310714,
-0.0093224645,
-0.007041862,
-0.007842073,
-0.016657738,
0.005421433,
-0.027180519,
-0.008975706,
0.0066284193,
0.010416087,
0.0041611,
0.0208055,
-0.00046887397,
-0.020245353,
0.017257895,
-0.012930085,
0.014763903,
0.0013011773,
-0.010929557,
-0.019205077,
0.019431803,
0.024406452,
0.009742576,
-0.017017832,
0.015537441,
0.0064617083,
-0.009075733,
0.00032654466,
0.023686262,
-0.0022122515,
0.011849799,
0.01427044,
0.031901766,
-0.02348621,
0.005491452,
-0.014297113,
0.024086367,
-0.03707647,
0.0019155064,
-0.01503064,
-0.011102935,
-0.008355542,
0.017658,
-0.015390736,
-0.033235453,
-0.0029257736,
0.0013778643,
0.010962898,
0.002170574,
0.018578244,
0.005668165,
-0.0049179667,
0.031528335,
0.017764697,
-0.0074553043,
-0.00942916,
0.037903354,
-0.00096775586,
0.0077887257,
0.002018867,
0.0074152937,
0.015990894,
0.019271761,
0.025300022,
-0.028860964,
0.030007934,
-0.025366707,
0.021619048,
-0.008162158,
-0.04318475,
-0.009749244,
0.0038910287,
-0.01095623,
0.005524794,
-0.001001098,
-0.012963427,
0.06588408,
0.01082953,
-0.024059694,
0.0026957127,
-0.009875944,
0.028967658,
0.006441703,
0.022005817,
-0.006441703,
-0.030968187,
0.022192534,
-0.009942628,
0.024273084,
-0.029181048,
-0.037529923,
0.026433656,
-0.013296849,
-0.0034975912,
-0.0024273084,
0.002827414,
0.0020355382,
-0.0076753623,
-0.0011594732,
0.008668958,
-0.04611886,
-0.005724847,
0.02747393,
0.012336595,
0.0065283924,
-0.0035976178,
-0.004257792,
-0.0152707035,
-0.044278372,
-0.022232544,
0.019898593,
-0.00007861453,
-0.008402221,
-0.031368293,
0.01409706,
0.012750037,
-0.0009969302,
0.028967658,
-0.010309393,
-0.037396554,
-0.008815664,
-0.0038210102,
-0.030888166,
-0.012009841,
0.0063850214
] |
The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocytes, crystal cells and lamellocytes--the functions of which are reminiscent of mammalian myeloid cells. During the first and early second instars of larval development, the lymph gland contains only progenitors, whereas in the third instar, a medial region of the primary lobe of the lymph gland called the medullary zone contains these progenitors, and mat | [
-0.016363515,
0.013399885,
-0.014864976,
-0.03312842,
-0.021287287,
0.01593536,
-0.0070645427,
-0.0059874677,
-0.030880615,
-0.011265805,
0.0006840431,
0.0015361701,
-0.009191933,
-0.0063420325,
-0.010616884,
0.022116836,
0.027174406,
0.003050598,
0.0024317815,
0.0075729755,
-0.0203507,
-0.010570054,
0.01240309,
-0.02397663,
0.0132460175,
-0.0002774221,
-0.004575897,
-0.015761422,
-0.01311891,
0.019240174,
0.0005753321,
0.011299254,
0.0049505318,
0.0011816049,
0.008556392,
-0.0045324126,
0.024953356,
-0.008262036,
0.0055660033,
0.016524073,
0.01450372,
0.016858568,
0.0019651605,
0.0016030691,
-0.012222461,
0.0032145006,
-0.033074904,
-0.001812965,
-0.012991801,
0.020417599,
0.020926032,
-0.0018915714,
-0.0069842637,
-0.00870357,
-0.015641004,
-0.009238763,
0.019869026,
0.0013296192,
0.017112784,
-0.027401863,
-0.008971167,
-0.010563364,
-0.023615375,
0.006442381,
0.018490905,
0.02036408,
-0.0038834915,
0.002145788,
0.01383473,
-0.008061339,
0.035750866,
0.0031994483,
0.010075001,
0.0029251622,
0.006224959,
-0.004565862,
-0.019240174,
-0.01675153,
-0.006512625,
0.0027027228,
0.013373125,
-0.036232542,
-0.013473474,
0.016805049,
0.013727691,
-0.0037965227,
0.015560726,
0.024297746,
-0.006234994,
-0.0013981907,
0.0051846784,
0.017474039,
0.01664449,
0.012710825,
0.0017895503,
-0.022652028,
0.005017431,
0.033101663,
-0.0023163806,
-0.03925638,
-0.017728256,
0.005231508,
-0.014624138,
-0.016497312,
-0.037276167,
-0.006883915,
0.017661357,
-0.013125599,
0.018999338,
-0.012148873,
-0.009526429,
0.032084797,
0.0203507,
-0.07364251,
0.029542632,
-0.03430585,
0.023374539,
0.017768396,
-0.011673889,
-0.009700366,
0.016149437,
0.027120886,
0.0332087,
-0.040246487,
0.033957973,
0.008014509,
-0.0017159614,
0.004789974,
-0.028793363,
0.022330912,
-0.007412418,
0.01015528,
-0.0070310934,
0.015641004,
-0.009794025,
0.00036982648,
-0.016778288,
0.012476678,
-0.0010151935,
-0.0114598125,
0.011078487,
0.038694426,
-0.019761987,
0.007914161,
-0.0032479502,
0.046775836,
0.030773576,
0.016403655,
-0.007051163,
-0.0052749924,
0.0009190261,
-0.024123808,
0.039684534,
-0.017875433,
0.008121548,
0.032780547,
-0.014543859,
0.027227925,
-0.023361158,
0.020390838,
0.003264675,
-0.0027830016,
0.02542165,
0.00800782,
0.010289079,
0.028953921,
0.012583717,
0.0049404968,
0.0070913024,
0.00076390384,
-0.01016197,
0.0087504,
-0.0132660875,
0.014008667,
-0.015426927,
0.02831169,
0.015761422,
-0.0096133975,
-0.03577763,
-0.018584564,
-0.0048301136,
-0.0047464897,
0.0044588237,
-0.00016118497,
-0.024645621,
-0.005760011,
0.0049906713,
-0.010409497,
-0.0113996025,
-0.0015102467,
0.0048802877,
0.004923772,
0.0046126912,
-0.021434465,
-0.6328118,
-0.0052381977,
0.014329783,
-0.025649106,
-0.0061848196,
0.015132572,
-0.0104563255,
-0.029863749,
-0.016805049,
-0.009660227,
-0.006455761,
0.010864411,
0.010603504,
-0.01948101,
-0.0035791006,
-0.025662486,
-0.0099211335,
-0.0031961035,
0.009158484,
-0.011580231,
-0.022598509,
-0.016724769,
-0.019092998,
0.011814377,
-0.005074295,
0.011954865,
0.03548327,
-0.00031463473,
0.0041076033,
0.027308203,
-0.016978987,
0.00014519191,
-0.0056696967,
0.012235842,
0.0391761,
0.012884762,
-0.015641004,
0.020096483,
0.008783849,
0.035804387,
-0.0021207007,
0.004863563,
0.02674625,
-0.00036104597,
-0.024391403,
0.001858122,
0.016992366,
-0.0055492786,
-0.00058787566,
0.0015704558,
-0.003114152,
-0.0073588984,
-0.015373408,
-0.008442664,
0.0037128988,
-0.005161264,
0.021996416,
-0.014222744,
-0.00094327703,
-0.003702864,
0.0059071886,
0.012148873,
-0.02175558,
0.009967962,
-0.0014257866,
-0.0023364504,
-0.013654102,
-0.004157778,
-0.0027779841,
-0.011198905,
0.006465796,
0.021314045,
-0.0021340805,
0.009452839,
0.0035456512,
0.011821067,
0.0034252328,
0.015413548,
-0.012784414,
0.014570619,
0.0067333924,
-0.0045457925,
-0.007820502,
0.013654102,
0.04270837,
-0.015533966,
0.0018497595,
0.014918494,
-0.00872364,
0.011513331,
0.009780645,
0.029221518,
-0.007599735,
-0.025662486,
-0.028900402,
0.014222744,
-0.006917365,
0.0024919906,
0.017554319,
-0.02836521,
-0.008583152,
-0.0075796656,
0.0063621025,
-0.0031007724,
0.008409214,
0.021247147,
-0.05220804,
0.009352491,
0.025729386,
-0.040781677,
-0.018584564,
0.005903844,
-0.013506924,
0.0058369446,
0.0064992453,
-0.0114598125,
0.01594874,
0.013981908,
0.0041745026,
-0.027348343,
0.00798106,
0.00327471,
0.013660791,
0.001266065,
0.017594457,
0.0025220953,
-0.01087779,
-0.024926597,
-0.008984546,
0.0073588984,
-0.0015244627,
-0.0018497595,
0.015814941,
-0.027294824,
0.031951,
0.019106377,
0.021969657,
-0.0024769383,
0.017781775,
-0.016992366,
-0.030720057,
-0.0153600285,
0.0023264154,
-0.0150522925,
-0.022116836,
-0.005760011,
-0.011821067,
-0.013359746,
0.0042614713,
-0.0053485814,
-0.011279184,
-0.010670403,
-0.026291337,
-0.002247809,
0.012851313,
0.005291717,
-0.010355977,
-0.010657023,
-0.00027993083,
-0.005783425,
-0.0007128933,
-0.00035268356,
-0.0030556154,
0.0188254,
-0.013968527,
-0.015881842,
-0.003478752,
0.010335907,
0.0008655068,
-0.032352395,
0.0052582677,
0.026612453,
-0.0077402233,
0.025675867,
0.010503155,
-0.020136623,
0.006609629,
-0.011807688,
0.00031588908,
-0.00044864195,
0.003906906,
-0.00800113,
-0.0034988218,
-0.014637519,
0.022986524,
-0.0033850933,
0.03617902,
0.020377459,
0.008857438,
0.019213416,
-0.007552906,
0.02463224,
-0.01012852,
-0.012095354,
-0.028873643,
-0.03261999,
0.0063018934,
0.01374107,
-0.00798106,
0.039711293,
0.01961481,
-0.021421084,
0.0024669035,
-0.017206443,
0.0101887295,
-0.042574573,
0.007205031,
-0.005355271,
-0.004087534,
0.022076696,
0.00798106,
-0.008395834,
-0.018343728,
0.012817863,
0.009961273,
0.0107640615,
0.013647412,
-0.011693959,
-0.003363351,
0.0056998013,
-0.011473192,
0.009981343,
0.027803257,
0.0030422355,
-0.007914161,
0.0008805591,
0.01089786,
0.005592763,
-0.0059874677,
-0.019467631,
-0.0009892702,
0.009907753,
0.005713181,
0.017005745,
-0.00006747399,
0.020658435,
-0.00874371,
-0.005244888,
0.010757372,
-0.024485063,
-0.00030585422,
0.009479599,
0.031549606,
-0.0035088568,
-0.004435409,
-0.030666538,
0.009606708,
-0.012289361,
-0.014209365,
0.0123295,
-0.01592198,
0.0010879462,
-0.016363515,
-0.00471973,
0.0048066988,
0.0024903181,
-0.010509845,
0.0029167999,
0.03114821,
0.018022612,
0.0037396585,
-0.014958634,
-0.013105529,
-0.016202956,
0.0037931777,
0.01818317,
0.0022595164,
0.0066397334,
-0.010844341,
-0.024284365,
-0.020792233,
0.018450765,
0.041156314,
-0.049318,
0.016122678,
0.0027830016,
-0.0024083669,
-0.006465796,
-0.011312634,
-0.0012175632,
-0.012449918,
-0.03422557,
0.0021508054,
0.036714215,
-0.0063587576,
-0.018704982,
-0.01309215,
0.009519739,
0.0120351445,
0.010616884,
0.019989444,
0.010008102,
0.00867681,
0.0030338732,
-0.009145104,
-0.017139545,
0.0059707426,
-0.0044889282,
0.019962685,
-0.011272495,
-0.011453122,
0.004398614,
-0.014276263,
-0.010797511,
0.052529156,
0.00033930378,
-0.0069976435,
-0.013995287,
0.0147846965,
-0.006475831,
-0.030720057,
-0.035269193,
0.010449636,
-0.02471252,
-0.011272495,
0.0012836261,
0.017193062,
0.030960893,
0.006321963,
0.0029184723,
-0.05062922,
-0.035162155,
-0.005749976,
-0.028900402,
0.016336756,
0.032325633,
-0.019400733,
0.019173276,
0.0018480871,
-0.00029644655,
0.0019785403,
-0.00075345085,
0.040166207,
0.018638084,
-0.0063018934,
-0.00471304,
0.01307208,
0.003089065,
-0.00059080246,
0.017313482,
-0.030425701,
-0.014195984,
-0.0011280857,
0.014289643,
0.024204087,
0.012824553,
0.017714877,
0.013145668,
0.017045885,
0.02247809,
-0.0025020256,
0.001016866,
0.0056094876,
-0.00042940845,
-0.018116271,
0.0051077446,
-0.0028465558,
-0.0011832775,
0.0046762456,
-0.013453404,
0.0051177796,
0.015038913,
-0.009252142,
0.0031760337,
0.017206443,
0.024993496,
0.002145788,
-0.021862619,
0.0064791758,
0.0017243237,
0.008944407,
0.0013187481,
0.0034988218,
-0.01379459,
0.039363418,
-0.009787335,
-0.00017278778,
-0.013399885,
0.017928952,
0.012690756,
-0.0051077446,
-0.0050341557,
0.005147884,
-0.00032550583,
0.004505653,
-0.0126305455,
0.017032506,
-0.0009692004,
-0.01015528,
-0.0035958255,
-0.01667125,
0.0009365871,
-0.02761594,
-0.022892864,
-0.010222179,
-0.007686704,
-0.0027863467,
-0.005154574,
0.010389427,
0.015025533,
0.027990574,
-0.0013823023,
-0.0026960329,
0.01376783,
-0.0032278805,
-0.022197114,
0.025568828,
-0.012724205,
-0.0066464236,
0.0069240546,
0.015105812,
-0.011372844,
-0.007492697,
-0.011914725,
0.0055358987,
0.011212286,
-0.013466785,
-0.0032027934,
-0.020484498,
0.015159331,
0.035055116,
0.0041076033,
-0.00080237084,
0.0023481576,
-0.0159755,
-0.028766604,
-0.031790443,
-0.00062090706,
-0.005004051,
-0.016069159,
-0.013687551,
0.010295768,
-0.036419857,
-0.009947893,
0.020859133,
0.0018898989,
0.005867049,
0.002731155,
0.021474604,
0.027334964,
-0.0038199374,
0.010422876,
0.020578157,
-0.010222179,
-0.0089979265,
-0.027508901,
0.0247259,
0.014222744,
-0.030934134,
0.004278196,
-0.0008078064,
-0.005676387,
-0.020136623,
0.009118345,
0.0054188254,
0.023668895,
0.0020772163,
-0.021595022,
-0.014570619,
0.0028381934,
-0.009539808,
0.014142465,
-0.007874021,
-0.019761987,
-0.0021089935,
0.02175558,
0.0009850889,
-0.03125525,
0.022933004,
-0.026572313,
-0.0030572878,
0.0075261462,
0.0018229999,
-0.0075261462,
-0.011627059,
-0.0055024493,
-0.012275981,
-0.0099010635,
0.0021123383,
-0.0030974273,
-0.003622585,
-0.022357672,
0.016283236,
0.03417205,
0.02170206,
0.003926976,
0.043966074,
0.020845752,
-0.012991801,
0.015119191,
0.007479317,
0.016912088,
-0.008656741,
0.01823669,
0.0036192401,
-0.0035055117,
0.016109299,
-0.022116836,
0.02245133,
0.037356444,
0.00017048811,
-0.017835295,
0.012510127,
-0.034412887,
-0.03973805,
0.010382737,
0.005666352,
0.004054084,
-0.038159233,
-0.013286157,
0.015841702,
-0.021193627,
-0.00869688,
-0.014249504,
0.02258513,
-0.025943462,
0.022919625,
0.0052649574,
0.013613963,
-0.0033265566,
-0.012102043,
-0.010442946,
-0.02401677,
-0.013393195,
-0.000746761,
0.0025137328,
-0.0006539385,
-0.013627342,
0.011486571,
-0.01962819,
-0.019119756,
-0.019052858,
-0.019373974,
-0.022411192,
-0.027027227,
-0.016256476,
-0.02900744,
-0.035215676,
0.023468196,
0.019240174,
-0.0031275318,
0.01164044,
-0.0015411875,
-0.024337884,
0.030158104,
-0.01885216,
0.022049936,
-0.039684534,
0.018771881,
0.04003241,
-0.013700931,
-0.027241305,
-0.011627059,
-0.012195702,
0.001430804,
0.04137039,
0.015333269,
-0.040754918,
-0.0050475355,
-0.0029502492,
0.017795155,
-0.0000064514493,
-0.010663713,
-0.00470635,
0.01529313,
-0.015426927,
-0.0044521336,
-0.014945254,
-0.021929517,
-0.009767265,
-0.0008972839,
0.015667764,
0.0012292706,
-0.009385941,
-0.008328935,
0.017126163,
-0.010703852,
0.0027763117,
-0.018651463,
0.017634597,
-0.010777442,
-0.026625833,
-0.052074242,
-0.011774238,
0.0071046823,
0.026946949,
-0.017607838,
-0.005830255,
0.017086025,
0.004552482,
-0.0008880853,
-0.016724769,
-0.020792233,
0.044822384,
-0.016938847,
0.008021199,
0.0071983407,
0.018959198,
0.012817863,
-0.009158484,
0.0037998676,
0.012081973,
-0.012891453,
-0.009526429,
0.024832938,
0.013159049,
-0.01748742,
0.00085129077,
-0.04003241,
-0.007131442,
-0.037249405,
-0.026291337,
-0.005960708,
-0.04080844,
-0.013165738,
0.033770654,
0.018812021,
0.020805614,
-0.008255347,
-0.022839345,
0.0058269096,
0.037971918,
0.01594874,
0.03609874,
-0.00023331054,
0.006903985,
-0.035884667,
0.012697445,
0.0019835576,
-0.019253554,
-0.0024468338,
-0.03484104,
-0.013754451,
-0.001055333,
-0.00043526213,
0.009158484,
-0.006174785,
-0.006656458,
0.006753462,
0.002570597,
0.01815641,
0.0013915008,
-0.002766277,
0.03617902,
-0.021193627,
-0.017915573,
-0.00546231,
0.0026291339,
0.0020638367,
0.010529915,
-0.017581077,
0.0057533206,
-0.006596249,
-0.022464711,
-0.010262319,
0.011479882,
-0.006977574,
0.008429284,
-0.025823044,
-0.009713747,
-0.018531045,
0.0040239794,
-0.0046695555,
-0.018504284,
-0.012784414,
0.012951662,
0.0026425135,
0.035991706,
-0.020952791,
0.008857438,
-0.0007651582,
-0.059138786,
-0.026973708,
-0.0013120582,
-0.024070289,
0.054589648,
0.008335625,
-0.009305662,
-0.0076398747,
0.01087779,
-0.02823141,
-0.030639777,
0.0051144348,
0.010590124,
-0.01236295,
0.03342278,
-0.0011088522,
-0.0022210495,
-0.0044788932,
0.006957504,
-0.0014843233,
-0.038293034,
0.021300666,
0.005830255,
0.015413548,
0.0032312255,
-0.023802692,
-0.026665973,
0.017821914,
-0.0046762456,
0.0025588898,
0.009707056,
-0.040300004,
0.015507206,
-0.020738713,
0.026706113,
0.014731177,
0.013674172,
0.0048100436,
-0.014851595,
-0.011520022,
0.004157778,
-0.01455724,
-0.01455724,
-0.007479317,
-0.00072878186,
0.011533401,
-0.00056027976,
-0.02104645,
-0.012416469,
0.015453687,
-0.007412418,
0.017661357,
-0.0095933275,
0.0063286526,
0.009038066,
0.007820502,
-0.011339393,
-0.0007935903,
-0.010630264,
-0.045518134,
-0.009626777,
0.0012426503,
-0.00217422,
0.00873033,
0.0017193063,
0.0017159614,
-0.0476589,
-0.00877047,
-0.009887684,
-0.013125599,
-0.038319793,
0.048006777,
-0.0035791006,
-0.027963815,
-0.0101686595,
0.005208093,
-0.002292966,
-0.022210494,
0.005127814,
0.007111372,
-0.0068504657,
-0.004789974,
-0.017367002,
0.006820361,
-0.012704135,
-0.030104585,
-0.013339676,
-0.010770751,
-0.010034862,
0.1772558,
-0.025836425,
0.0065092803,
-0.0036359648,
-0.004783284,
-0.02898068,
0.030720057,
0.0031810512,
0.008435974,
0.00003420738,
0.017795155,
0.006020917,
-0.012249221,
0.013192498,
0.020150002,
-0.03775784,
0.005137849,
-0.0009917788,
-0.0049070474,
-0.025769524,
-0.009024685,
0.00004868476,
-0.000890594,
0.00362593,
0.053358704,
0.007840572,
-0.014583999,
0.0035322714,
0.009399321,
0.014182605,
-0.017688116,
0.0015671109,
0.0007367261,
0.0013839747,
0.033181943,
-0.0003696174,
-0.013159049,
-0.0030990997,
0.008984546,
0.000103954895,
0.03267351,
-0.009519739,
0.002142443,
0.023749173,
0.008589841,
0.033155184,
0.0013321278,
-0.0055459337,
-0.016376894,
0.009145104,
-0.043029487,
0.023080181,
-0.0010419531,
0.02107321,
0.008201827,
0.0013831385,
0.009312351,
0.010449636,
-0.002808089,
0.025568828,
-0.024003388,
0.021260528,
-0.020725334,
0.021447845,
0.0025488548,
0.005582728,
-0.012182322,
-0.008904267,
0.016470553,
-0.024257606,
-0.012222461,
-0.013332986,
-0.02686667,
-0.0030556154,
0.00025024437,
0.005452275,
0.019307073,
0.021287287,
-0.0001058887,
0.0050508804,
0.009138414,
-0.0023013283,
-0.019855646,
-0.00073296303,
0.020845752,
-0.017728256,
0.011339393,
0.017888814,
-0.02758918,
-0.03845359,
-0.0060644015,
-0.02531461,
-0.0059975022,
0.00012041834,
0.028606046,
-0.0010570055,
0.026518794,
0.016858568,
-0.00028411203,
-0.013486854,
-0.020471118,
0.054027695,
0.035376232,
0.019186655,
-0.0062684435,
0.01823669,
-0.0048368033,
0.0070712324,
-0.017259963,
-0.009680296,
0.013754451,
-0.023254119,
0.01238302,
-0.010369357,
0.0011489916,
0.01302525,
0.02753566,
-0.019373974,
0.0089377165,
0.011901346,
0.00363262,
-0.012811174,
0.025689246,
0.023441438,
-0.022812586,
-0.01675153,
-0.023802692,
0.008623291,
-0.0017878779,
-0.037436724,
-0.004214642,
-0.013366436,
-0.009319042,
0.03109469,
0.014972013,
-0.009713747,
-0.0101419,
0.013526994,
-0.036848012,
-0.0041644676,
-0.0076599442,
-0.0089778565,
0.012523508,
-0.011740788,
0.01309215,
-0.0067200125,
0.02689343,
0.02108659,
-0.032753788,
-0.016805049,
-0.011546781,
-0.03125525,
-0.0004141471,
-0.011800997,
0.0188923,
-0.041985862,
-0.029489113,
-0.002241119,
0.033957973,
-0.01161368,
-0.013968527,
0.0038768016,
-0.00011121972,
-0.021528123,
0.0066296984,
-0.011580231,
-0.16805048,
-0.016296616,
0.03698181,
-0.005505794,
0.023361158,
0.01664449,
-0.00068320683,
0.011158766,
0.008837368,
0.018357107,
0.041878823,
0.015065673,
-0.045223776,
-0.0350016,
-0.0017209788,
0.00017613273,
-0.0017728256,
0.055981148,
0.02176896,
0.011265805,
0.02321398,
-0.01742052,
0.040326763,
0.0031375668,
0.0035188915,
0.02678639,
0.018959198,
-0.0016197939,
-0.005281682,
-0.040273245,
-0.01819655,
-0.002731155,
0.0021273906,
-0.012369639,
0.0061112307,
0.0061313007,
0.008328935,
-0.02036408,
0.00054230064,
-0.002289621,
0.017340241,
0.004723075,
-0.0011540091,
0.018651463,
0.0027077403,
0.050441906,
-0.014303023,
-0.009098275,
0.029944027,
-0.01816979,
0.040674638,
0.009640157,
-0.014878355,
0.009479599,
0.011533401,
0.013312916,
0.008409214,
0.013379816,
0.01664449,
0.0067233574,
-0.001742721,
-0.012209082,
0.039791573,
-0.009385941,
0.027241305,
-0.01956129,
-0.007158201,
0.024739278,
-0.01960143,
-0.0013120582,
-0.014771316,
-0.0011673889,
0.019467631,
-0.00871695,
0.022906244,
0.027883535,
-0.013346366,
0.0055626584,
0.014436821,
0.009131724,
-0.023040043,
0.025635727,
-0.027268065,
-0.019119756,
-0.020524638,
-0.007037783,
-0.0101419,
0.030184865,
0.009660227,
0.0007672488,
0.032753788,
-0.01887892,
-0.006442381,
-0.023120321,
0.017032506,
0.035938185,
-0.02386959,
-0.032138318,
0.012503438,
0.035188913,
0.016858568,
-0.0038768016,
-0.025809664,
-0.0043885796,
0.005749976,
0.011780928,
-0.028391968,
0.010095071,
0.049665876,
-0.029194757,
-0.0029719917,
-0.0032830723,
0.014905115,
0.022973143,
0.008288796,
0.032486193,
0.021595022,
-0.018290209,
0.03203128,
-0.01164044,
0.06315273,
0.0070110234,
-0.006743427,
0.027749738,
-0.015212851,
0.0078071225,
-0.13711636,
-0.020939412,
0.0008383291,
0.008469423,
-0.012229151,
0.019869026,
-0.0049605668,
0.020872513,
-0.0068069813,
0.013567133,
-0.023494957,
-0.0016657871,
-0.0057533206,
-0.017888814,
0.00869688,
-0.013714311,
0.011874586,
-0.018410627,
-0.0053954106,
0.02906096,
0.015453687,
0.0063654473,
-0.02609064,
-0.0122826705,
0.010743992,
0.011499952,
-0.03987185,
0.01449034,
0.02911448,
0.013239328,
0.026732871,
-0.031067932,
0.026478656,
-0.0043216804,
-0.022866106,
-0.011921416,
-0.01953453,
-0.013172428,
0.045223776,
-0.022330912,
-0.02175558,
-0.0029786814,
0.005164609,
-0.031977758,
-0.0072986893,
-0.014945254,
-0.006368792,
0.0038400071,
0.014316402,
-0.001146483,
-0.0348678,
-0.04367172,
-0.033904452,
-0.008783849,
0.024578722,
-0.015065673,
0.006512625,
0.0068638455,
-0.013353056,
-0.0042347116,
-0.0033683686,
-0.0015219541,
-0.0033600063,
-0.026679352,
0.032218598,
-0.0010151935,
-0.013727691,
-0.020992931,
0.038239513,
-0.041450668,
-0.01012852,
0.0038299721,
-0.0057633556,
-0.008134928,
-0.014650898,
0.016952226,
-0.007646565,
0.024538582,
-0.0010511518,
-0.026639214,
-0.007131442,
-0.013252707,
0.012289361,
0.0014140792,
0.027161026,
0.0034519925,
0.020685196,
-0.010382737,
0.021942897,
-0.0047598695,
-0.01601564,
0.031951,
0.0039370107,
-0.017179683,
-0.021474604,
0.0029686466,
0.014717797,
0.006586214,
0.051271453,
0.03141581,
-0.021300666,
-0.008041269,
-0.059888054,
-0.010309148,
-0.0068069813,
0.00507764,
0.0044889282,
-0.045625173,
0.00011236955,
-0.01656421,
0.033021387,
0.017233202,
-0.0033951283,
0.013567133,
-0.017755015,
-0.019507771,
-0.012643926,
-0.03837331,
0.025622347,
0.00031045353,
0.0051043998,
0.016791668,
0.0032345704,
0.00026592382,
0.018410627,
0.011326014,
-0.0029619567,
-0.0064356914,
0.01594874,
0.024525203,
-0.003987185,
-0.009084895,
-0.019200036,
-0.06320625,
-0.0028800054,
-0.019735228,
-0.015159331,
-0.032405913,
-0.0031877412,
0.0070645427,
0.038908504,
0.032272115,
-0.003920286,
-0.023387918,
0.024056908,
-0.011814377,
-0.015145951,
-0.0005456456,
-0.024739278,
-0.0060543665,
0.0029318521,
0.00061129034,
0.060155652,
-0.0120351445,
0.0076398747,
-0.037436724,
-0.011627059,
-0.00079233595,
0.027455382,
-0.01739376,
0.005010741,
0.011272495,
0.014798076,
0.025996981,
-0.0072853095,
-0.023722414,
-0.0073789684,
-0.023789313,
-0.019360593,
0.0051177796,
-0.018597944,
-0.007780363,
-0.013506924,
0.015667764,
0.026291337,
0.014209365,
0.01893244,
-0.0047030053,
-0.01383473,
-0.000019756135,
-0.020818993,
0.029194757,
0.009406011,
-0.006810326,
0.019454252,
0.03773108,
0.038614146,
0.02321398,
-0.014262884,
0.039604254,
-0.00047331097,
0.006970884,
-0.006823706,
0.02040422,
0.015560726,
0.006429001,
0.012182322,
0.019213416,
-0.003993875,
0.01740714,
-0.004217987,
0.04129011,
0.0021591678,
0.009098275,
0.019293694,
-0.038614146,
-0.001311222,
0.014891735,
-0.011352774,
-0.040942237,
0.007693394,
0.017755015,
0.00871695,
-0.008215207,
-0.0048301136,
0.0006869699,
-0.024431543,
0.0048066988,
-0.0038834915,
-0.018009232,
-0.0035255814,
0.028713085,
0.005208093,
0.02540827,
-0.016724769,
-0.010643643,
-0.0027779841,
0.010570054,
0.031603124,
-0.014048806,
0.004947187,
0.0010820926,
-0.00051010546,
0.005893809,
-0.036125503,
-0.019052858,
0.0050274655,
-0.0057800803,
0.014771316,
0.0057098363,
-0.020765474,
0.07326787,
0.00047540158,
-0.015734663,
0.002443489,
-0.010409497,
0.025903324,
0.0068437755,
0.005305097,
-0.018651463,
-0.025782906,
0.018531045,
-0.0026659283,
0.022718927,
-0.02610402,
-0.023816071,
0.02476604,
-0.026692731,
-0.005030811,
-0.030265143,
-0.0150924325,
0.011754168,
-0.024605481,
0.010616884,
0.01664449,
-0.017741635,
0.005867049,
0.012249221,
-0.01957467,
0.019039478,
-0.010844341,
0.015707904,
-0.004565862,
-0.04340412,
-0.008282105,
-0.012449918,
0.006020917,
-0.0013705948,
-0.042521056,
0.011573541,
0.04134363,
-0.013547064,
0.010556675,
-0.00217422,
-0.013667482,
0.009807405,
-0.0029234898,
-0.011921416,
-0.007191651,
0.001774498
] |
Multiple cellular stressors, including activation of the tumour suppressor p53, can stimulate autophagy. Here we show that deletion, depletion or inhibition of p53 can induce autophagy in human, mouse and nematode cells subjected to knockout, knockdown or pharmacological inhibition of p53. Enhanced autophagy improved the survival of p53-deficient cancer cells under conditions of hypoxia and nutrient depletion, allowing them to maintain high ATP levels. Inhibition of p53 led to autophagy in enucleated cells, and cytoplasmic, not nuclear, p53 was able to repress the enhanced | [
-0.009743984,
-0.024503637,
0.019318165,
-0.019788384,
-0.024673438,
0.027246581,
-0.014550667,
0.00843782,
-0.025195904,
0.002396811,
0.019879816,
0.0014645364,
0.025679184,
0.017985879,
-0.004300545,
0.0028131509,
0.03704281,
0.0045127966,
-0.009946439,
0.006364284,
-0.027847417,
0.038819194,
-0.0074124807,
-0.016496852,
0.0026368187,
0.017972818,
0.01010971,
-0.040569454,
0.012121202,
-0.008156994,
0.0065732705,
-0.012865716,
0.000354297,
-0.009156209,
0.0028196815,
-0.010540743,
0.024007294,
-0.015386612,
0.01926592,
-0.0070598167,
0.000068420544,
0.019971248,
-0.013401243,
0.0117032295,
-0.0050842436,
-0.0014441276,
-0.024490576,
-0.015308242,
-0.005041793,
-0.0004522593,
0.0020212887,
-0.0056099747,
-0.023119103,
0.009646022,
-0.032392867,
0.0054662963,
-0.019200612,
0.025705308,
0.0052442485,
-0.015308242,
0.0024670174,
-0.015255996,
-0.023902802,
0.015987448,
0.00867946,
0.013453489,
0.0069292,
0.0071969638,
0.0010939124,
-0.011428935,
0.041118044,
0.030773224,
-0.008333326,
0.007020632,
-0.00312663,
-0.028657239,
-0.012108141,
0.024490576,
-0.0031347936,
0.012833062,
0.00549242,
-0.025613876,
0.012173449,
0.027115965,
0.0060377433,
0.003221327,
-0.02054596,
0.009979093,
0.0296238,
0.010077056,
0.015660906,
0.018534468,
0.029022966,
0.022505207,
-0.010410127,
0.030773224,
-0.0008628846,
0.02379831,
-0.018194865,
-0.039524525,
-0.020637391,
0.0049013807,
-0.00047225994,
-0.009463158,
-0.020663515,
-0.0065406165,
0.01417188,
-0.0047968873,
0.0006710418,
-0.008352919,
-0.017136872,
0.015817646,
-0.01425025,
-0.050835904,
0.017424228,
0.011677107,
0.0071773715,
0.014315558,
-0.03670321,
-0.0008579865,
0.018142618,
0.016927887,
0.028813979,
-0.013949832,
0.015791522,
0.00748432,
-0.0045813704,
0.008261488,
-0.016431544,
-0.0064459196,
0.016901763,
0.039132673,
0.014354743,
0.0014678019,
-0.01639236,
0.025744492,
-0.03887144,
-0.010142364,
-0.024634253,
-0.040882934,
0.0038499185,
0.024477514,
-0.015478044,
-0.0058744727,
-0.015112318,
-0.010684422,
0.019879816,
-0.0014433112,
-0.0017404635,
0.029728293,
0.010083586,
-0.005672017,
0.016692776,
-0.028813979,
0.013623291,
0.0015273956,
0.0037388946,
-0.002431098,
-0.027115965,
-0.030041773,
0.0054042535,
-0.008999471,
0.012336719,
0.0028915207,
0.006223872,
0.025522444,
0.021590892,
0.011422404,
-0.008483536,
-0.002447425,
0.014341681,
0.039132673,
-0.017502598,
0.01728055,
-0.027168212,
0.008535782,
-0.0022384387,
0.017998941,
-0.028526623,
-0.0025437544,
-0.013610229,
0.037722018,
0.01609194,
0.019814508,
-0.0052801683,
0.0068051144,
0.027246581,
-0.036259115,
0.013662476,
-0.005845084,
0.003797672,
-0.00418299,
-0.016914824,
-0.014341681,
-0.6349002,
-0.027664553,
0.014798839,
-0.00409809,
-0.0060540703,
0.04158826,
0.019540213,
-0.0052671065,
-0.014433113,
0.00086778274,
-0.010155425,
0.031478554,
0.020885563,
-0.011637921,
-0.0044899387,
-0.026645746,
-0.017985879,
-0.018116495,
0.04984322,
0.010005216,
-0.0048132143,
-0.0056981407,
-0.030982211,
0.001400861,
0.008163525,
0.025940418,
0.02970217,
-0.019474905,
0.015739277,
0.042972796,
-0.015804585,
0.0197492,
-0.014433113,
-0.012336719,
0.052298807,
-0.00006607353,
-0.010638706,
0.03288921,
0.015974386,
0.036572594,
-0.0027331482,
0.0023102777,
0.023928925,
-0.0034384767,
-0.02229622,
0.004111151,
-0.012003647,
-0.009241111,
0.0033029623,
0.0029127458,
0.023210535,
0.024647316,
-0.027899664,
-0.001021257,
0.031347938,
0.02349789,
0.026750239,
-0.028317636,
0.0126044825,
0.0020082272,
0.022727255,
0.01425025,
-0.0060736625,
-0.014785777,
-0.020206358,
0.036102373,
-0.002098026,
-0.006458981,
-0.007915354,
-0.003503785,
0.029310321,
0.0052246563,
-0.016196433,
0.013100825,
0.0025045695,
0.03106058,
-0.009757046,
0.019553276,
0.0017176057,
-0.006272853,
-0.0018139353,
-0.016536037,
-0.039393906,
0.015478044,
0.018521406,
0.0039674733,
-0.024960795,
0.027351074,
-0.013505736,
0.009521936,
-0.01512538,
-0.006393673,
-0.008921101,
-0.026750239,
-0.035318676,
0.0039544115,
-0.021865185,
0.0007290028,
0.015425798,
-0.013740846,
-0.016588284,
-0.009149679,
0.010723607,
0.000050562834,
0.02173457,
0.01249999,
-0.030929964,
-0.020676577,
0.03735629,
-0.028160896,
0.012989801,
-0.0043691187,
0.022439899,
-0.0011151376,
0.00086043554,
-0.022975426,
0.019370412,
0.03685995,
-0.009606836,
-0.02126435,
0.017541783,
0.00040511493,
0.0112852575,
-0.011631391,
0.0109456545,
0.012774284,
0.009659083,
-0.020350035,
-0.015464982,
-0.012304065,
-0.0090125315,
-0.009358665,
0.010442781,
-0.015752338,
0.023589322,
0.00040695173,
0.007223087,
-0.00060940714,
0.02460813,
-0.024582008,
-0.030538116,
0.004920973,
0.0052377176,
0.006256526,
-0.008013316,
-0.0003732772,
-0.023563199,
-0.0056981407,
0.019017749,
0.010508089,
-0.0044148345,
0.012754692,
-0.020885563,
0.0057209986,
0.025104472,
-0.00700757,
-0.023706878,
-0.023001548,
0.0004628719,
-0.02029779,
0.0073275804,
0.0246865,
-0.000722472,
0.02029779,
-0.010103179,
-0.0010065626,
0.011095864,
0.012545706,
-0.007523505,
-0.021290474,
0.002396811,
-0.02556163,
-0.00037041996,
0.007654121,
-0.0059038615,
0.014433113,
-0.0030547911,
-0.010018278,
-0.007954539,
-0.00032184698,
0.021891309,
-0.029963402,
0.00031409162,
0.003232756,
0.022257036,
0.025078349,
0.037852634,
0.011455058,
0.0019592461,
0.03200102,
-0.00077390217,
0.006377346,
-0.003077649,
0.021538645,
0.004205848,
-0.035710525,
-0.0061128475,
0.012095079,
0.017345859,
0.03254961,
-0.008209241,
-0.018599777,
0.0105276825,
-0.016340112,
0.025574692,
0.021394966,
-0.0036605247,
-0.017672399,
-0.0018759781,
0.010599521,
-0.0017339328,
0.020193296,
-0.018665085,
0.0025045695,
0.0024261996,
0.018808762,
0.0013314709,
-0.014328619,
-0.012708976,
-0.019683892,
0.010743199,
-0.0036180743,
0.0033535762,
-0.014367804,
0.0015543352,
0.03278472,
0.009019063,
0.033646785,
0.0029584616,
-0.0036964442,
0.0035005196,
0.025927356,
0.00015939283,
0.013211849,
0.024934672,
0.026541254,
-0.008816607,
-0.0011061577,
0.03733017,
0.0029976463,
-0.014315558,
0.0015151503,
-0.0026106953,
0.0065340856,
-0.010854223,
-0.0026106953,
0.033803526,
0.0017241365,
-0.031504676,
-0.010697483,
-0.019801447,
0.021199042,
-0.008901508,
0.004689129,
-0.007797799,
-0.025848987,
-0.01138322,
-0.006442654,
0.04299892,
0.023576261,
0.0195794,
-0.012369374,
-0.0029649923,
-0.0023396662,
0.0070990017,
0.007627998,
0.02579674,
0.015491106,
0.0014620874,
-0.011886093,
-0.0391588,
0.004006658,
0.011200356,
-0.032105513,
0.010873816,
0.013897586,
0.004169929,
0.013753907,
0.015138441,
0.0011037086,
-0.018691208,
-0.012957147,
0.04098743,
0.029205827,
-0.001433515,
-0.009293357,
-0.03638973,
-0.014446174,
0.018168742,
0.010305634,
-0.0031805094,
-0.0044083036,
-0.0064720428,
0.012454274,
-0.02682861,
-0.017123811,
0.009730922,
-0.024164034,
0.025496323,
-0.010266449,
-0.0017045441,
-0.0025878374,
-0.031269565,
0.030956088,
0.0074124807,
0.008934162,
0.0051462865,
-0.0083202645,
0.0006873688,
-0.040020864,
-0.016901763,
-0.0073406417,
0.014433113,
-0.0024784463,
-0.024190158,
-0.015621722,
-0.0059397807,
0.01735892,
0.014798839,
0.028918471,
-0.009188864,
-0.011970993,
-0.009659083,
-0.011970993,
0.035161935,
0.03471784,
-0.0078369845,
0.019200612,
0.016745023,
0.020898625,
0.0063577536,
-0.016549097,
0.03942003,
-0.031870402,
-0.031739786,
-0.0029911157,
0.00091921294,
-0.0035005196,
0.03709506,
0.021721508,
-0.018508345,
-0.011206888,
-0.029832786,
-0.010658299,
0.009267234,
-0.027272705,
0.021212105,
0.028474376,
0.023406459,
0.013989016,
0.02667187,
0.013185726,
0.0016531139,
-0.0037095058,
-0.0069161383,
0.020441467,
0.007843515,
0.0026596766,
-0.002341299,
-0.034456607,
0.013309811,
0.04221522,
0.0010130935,
0.014537605,
0.00048450523,
0.013388181,
-0.0008628846,
-0.01257836,
0.009130087,
-0.0015429063,
0.0077520837,
0.02014105,
-0.017881386,
-0.021277413,
0.039315537,
-0.017476475,
-0.014406989,
-0.010834631,
0.009881131,
-0.0030303006,
-0.020010432,
0.003110303,
-0.010658299,
-0.010952186,
0.0074647274,
-0.013675537,
0.010664829,
-0.012402028,
0.013211849,
-0.003376434,
0.010207672,
-0.011050148,
-0.027533937,
-0.009365196,
0.0075692204,
-0.024229342,
-0.029205827,
0.017162995,
-0.004372384,
0.03129569,
0.0031152011,
-0.008274549,
-0.014406989,
0.033307184,
-0.003774814,
-0.022570515,
-0.0153604895,
-0.05088815,
0.02652819,
-0.008640275,
0.00077757577,
-0.029597677,
-0.023040734,
0.0014416785,
0.012036301,
-0.02412485,
0.00955459,
0.013832277,
-0.011840377,
0.0021551705,
0.013375119,
0.017998941,
0.012193041,
0.009273765,
0.016627468,
-0.032418992,
-0.033176567,
-0.02435996,
-0.027742924,
-0.026697993,
0.003200102,
0.004871992,
-0.0068116453,
-0.013505736,
0.00022021109,
0.008966816,
-0.00780433,
-0.009600306,
0.013146541,
0.02698535,
0.0048132143,
0.009855008,
-0.0072034947,
0.008019847,
-0.046212085,
-0.008026378,
0.017855262,
0.014315558,
-0.0068769534,
0.008646806,
-0.021551706,
-0.019670831,
-0.022688068,
0.0023755857,
-0.04007311,
0.03798325,
0.01648379,
-0.018181803,
-0.004189521,
0.004388711,
-0.013296749,
0.012323658,
0.0007816575,
-0.03503132,
-0.018103434,
0.005763449,
0.0027609041,
-0.01759403,
0.021995801,
-0.039785758,
-0.02038922,
0.019383473,
-0.009352135,
0.0064687775,
-0.010782384,
-0.007948008,
-0.016144188,
-0.0085945595,
-0.032079387,
-0.035083566,
-0.003791141,
-0.011415874,
0.02938869,
0.02652819,
0.031165075,
-0.0046793325,
0.022727255,
0.028578868,
0.008463943,
-0.013002863,
-0.00867946,
0.04393936,
-0.0068377685,
0.03733017,
0.0044997353,
-0.00032286742,
0.0102207335,
-0.000049823015,
0.0071969638,
0.017998941,
-0.013649414,
-0.022309281,
0.0020000637,
-0.034743965,
-0.016131125,
0.023785247,
-0.022949303,
0.0029764213,
-0.020637391,
-0.013675537,
0.010860754,
0.018482221,
-0.008274549,
-0.01010971,
0.00005872636,
-0.027664553,
0.014420051,
-0.0040164543,
-0.0067659295,
-0.005623036,
-0.013884524,
0.011272196,
-0.015726214,
0.00085227203,
0.0065765358,
0.0072883954,
0.011030556,
-0.026880857,
-0.005103836,
0.005560993,
-0.014981701,
-0.027298829,
-0.022910116,
-0.043913234,
-0.04038659,
-0.012539174,
0.00070451223,
-0.006570005,
-0.01297674,
0.029284198,
-0.020689638,
0.0030956087,
0.012291004,
-0.02285787,
0.0285005,
-0.0045911665,
0.02348483,
-0.007621467,
0.01114811,
0.027220458,
0.00020939442,
-0.011259134,
-0.0060018236,
-0.0026106953,
0.008699052,
0.017776892,
0.023994233,
-0.00033531678,
-0.019305104,
-0.009378258,
-0.007856577,
-0.01106974,
-0.0146029135,
0.040177606,
0.018638961,
0.015334366,
-0.0037486907,
-0.01776383,
-0.02834376,
-0.0014792308,
-0.008607621,
0.013989016,
-0.0060148854,
0.011206888,
-0.028735608,
0.014106572,
0.0024213016,
-0.0012000382,
-0.0026057973,
-0.022113357,
0.008868854,
-0.019017749,
0.009593775,
0.01553029,
-0.033150442,
0.008672929,
0.007758614,
0.0028425395,
0.005436908,
0.0022661947,
0.0034025572,
0.0032784718,
-0.018207926,
0.0368077,
-0.0187957,
-0.011768538,
-0.0010122771,
0.012193041,
0.0045356546,
-0.00971786,
-0.0060703973,
0.015961325,
-0.028082527,
-0.0053062914,
0.0020359831,
0.012467336,
-0.0062304023,
-0.015229872,
-0.020271666,
-0.0066549056,
-0.019226735,
-0.024177097,
0.012003647,
-0.027324952,
-0.015112318,
-0.0013208584,
0.018652022,
0.012833062,
-0.005740591,
0.009417443,
-0.016745023,
0.054336425,
0.00095839787,
0.007712899,
0.007954539,
-0.009417443,
-0.007843515,
0.012852654,
-0.012597952,
-0.013342465,
0.003487458,
-0.01401514,
-0.03273247,
-0.019514091,
-0.010331757,
0.037304044,
0.010135833,
0.008222302,
0.03560603,
0.014537605,
0.012369374,
0.011030556,
-0.005495685,
0.009221518,
-0.0074581965,
0.027690677,
0.031818155,
-0.0042646257,
-0.022531329,
-0.0037650177,
-0.0058646766,
0.0052050636,
-0.0029600943,
-0.034195375,
-0.016522976,
-0.005518543,
0.012630606,
-0.0015314773,
0.01131138,
-0.009966032,
-0.012565298,
0.0038825725,
-0.0057373256,
0.022374589,
-0.021865185,
0.006948793,
0.014276373,
-0.0026874326,
-0.009861538,
0.009972562,
-0.002452323,
-0.018456098,
-0.016418481,
0.003503785,
-0.022335405,
0.020323912,
0.00061634614,
-0.016418481,
0.0064851046,
-0.007823923,
-0.018220989,
-0.012833062,
0.0026809017,
0.0007857393,
0.0028360086,
0.009365196,
-0.020101864,
-0.011925277,
-0.003702975,
0.026214711,
0.013910647,
-0.010899939,
-0.004444223,
-0.006792053,
0.0017306673,
-0.010801977,
-0.017607091,
-0.01122648,
-0.0018612838,
-0.03025076,
-0.023863617,
0.034143128,
0.018194865,
0.015634783,
-0.016313989,
0.01067136,
0.010370943,
0.017110748,
0.019383473,
-0.011579144,
-0.002906215,
0.031870402,
0.011396281,
0.0061520324,
0.0013037149,
-0.0001669441,
0.013662476,
0.0065242895,
-0.023746062,
-0.04911177,
-0.0017992409,
-0.0060246815,
0.015595598,
0.036886074,
-0.0009869701,
0.009593775,
-0.00058042665,
-0.004819745,
-0.022204788,
-0.0153604895,
-0.0059887622,
-0.0019935328,
0.016980132,
0.013949832,
-0.006498166,
0.008953755,
0.017633215,
-0.019866755,
-0.014563729,
-0.020088803,
0.00246865,
-0.020728823,
0.026097158,
-0.012571828,
-0.0023478298,
-0.002862132,
-0.004767499,
-0.016692776,
-0.025182843,
0.015269058,
-0.016274804,
-0.0036997097,
-0.010501559,
0.002037616,
0.007079409,
0.002403342,
-0.008633744,
-0.009861538,
-0.0131204175,
0.028082527,
0.18202703,
-0.027664553,
-0.00020582289,
0.011533428,
0.005619771,
-0.0058026337,
0.0011502407,
-0.009006001,
-0.008333326,
-0.0064459196,
0.012212634,
0.00835945,
-0.013146541,
-0.0054826234,
-0.003033566,
-0.01942266,
-0.028657239,
-0.0009600306,
-0.010259919,
-0.0027641696,
0.020807194,
-0.023772186,
0.01824711,
0.0060246815,
0.03685995,
0.013015925,
-0.025248151,
0.0053650686,
0.024164034,
-0.0043985075,
-0.03346392,
-0.014642099,
0.013571044,
-0.015987448,
0.013316343,
0.015621722,
-0.021277413,
-0.0057993685,
0.011076271,
-0.00979623,
-0.0006783889,
0.0053160875,
0.0070663476,
0.0052050636,
-0.013231441,
0.012336719,
-0.01648379,
-0.014237188,
0.02499998,
-0.0034286806,
-0.055694833,
-0.0022825217,
0.018469159,
0.019514091,
-0.012454274,
0.0013224911,
0.005711202,
-0.008633744,
0.012036301,
0.036520347,
-0.0004902197,
0.00986807,
-0.03581502,
0.016509913,
-0.019775324,
0.007588813,
-0.016784208,
0.0067136833,
0.03740854,
-0.024320774,
-0.013505736,
-0.008418228,
-0.027978033,
0.00020531265,
-0.0048295413,
-0.015882954,
0.011748945,
0.0034646,
0.02842213,
0.02556163,
0.010442781,
0.012852654,
-0.0014351477,
0.0031070376,
-0.006968385,
-0.04132703,
0.020598207,
0.031426307,
-0.017176056,
-0.027429445,
0.015478044,
-0.0017796485,
-0.00414054,
-0.006354488,
0.003526643,
-0.0019576133,
0.017215243,
0.009534998,
-0.0037486907,
-0.026959226,
-0.031400185,
0.09054329,
-0.029597677,
-0.006935731,
-0.025065288,
0.005789572,
0.0022776236,
-0.0010555438,
-0.0058907997,
0.0036180743,
0.02429465,
-0.022583576,
-0.0019510825,
-0.002091495,
0.0044605504,
0.038348977,
0.0070990017,
-0.007823923,
0.04516715,
-0.021329658,
-0.008992939,
-0.025222028,
0.0134273665,
0.011690168,
0.0026057973,
0.0028490704,
-0.038427345,
0.0017861793,
-0.0064393887,
-0.022439899,
0.019775324,
0.0027037596,
-0.021303535,
0.032706346,
0.02348483,
0.00069185876,
0.0044050384,
-0.013322873,
0.0015731113,
0.010161956,
-0.026162466,
-0.009646022,
0.004689129,
0.019696953,
-0.0131204175,
-0.00066083734,
0.024830177,
0.004911177,
-0.0037258328,
-0.020506775,
0.0026449822,
-0.010775853,
-0.034534976,
-0.0012931024,
-0.000068624635,
-0.02803028,
-0.0044148345,
-0.01856059,
-0.0016351541,
0.00038735927,
-0.018939378,
-0.0029127458,
0.012388966,
-0.01854753,
-0.00031735704,
-0.009306419,
-0.16238232,
0.012643668,
0.005080978,
-0.01537355,
0.012042833,
0.022165604,
-0.011272196,
-0.0014792308,
-0.011344034,
0.0040393122,
0.023471767,
-0.0059038615,
-0.05726223,
-0.022243973,
0.0296238,
-0.0034090881,
-0.0036213398,
0.032131635,
0.0059822313,
0.0011469753,
0.01887407,
-0.026149403,
0.02014105,
0.0066744983,
-0.007660652,
0.02756006,
0.0027870275,
-0.020088803,
-0.003431946,
-0.0046793325,
-0.029414814,
0.011801192,
0.00633163,
0.0005608342,
0.0033568416,
-0.0029747887,
-0.011089332,
-0.0025502853,
0.001032686,
0.025848987,
0.03001565,
0.022883995,
0.008019847,
0.0035462354,
-0.0016433176,
0.022714192,
-0.013068171,
-0.0058712075,
0.0021404764,
-0.018782638,
0.026462883,
-0.0011306482,
0.01790751,
0.024242405,
0.0036768517,
0.0019837366,
0.028369883,
-0.009365196,
0.003392761,
-0.005632832,
-0.0044017727,
-0.011082802,
0.028291512,
0.013753907,
0.00014898434,
-0.045297768,
-0.009463158,
-0.004267891,
-0.005054855,
-0.000002723301,
-0.010024809,
-0.007040224,
0.0227795,
-0.011024024,
0.006380611,
0.012114671,
-0.018207926,
0.01823405,
-0.015791522,
0.022270096,
-0.017319735,
0.0060736625,
-0.023315027,
-0.033228815,
-0.012460805,
-0.0074581965,
-0.00015112726,
0.014106572,
-0.02818702,
0.0040033925,
0.01010971,
-0.006570005,
-0.010364411,
0.00045103478,
0.025195904,
0.01131138,
-0.011794661,
-0.01568703,
0.0030923435,
-0.012715507,
0.004754437,
-0.005469562,
-0.016496852,
0.0006000191,
0.04610759,
-0.0013420836,
-0.018991625,
0.0010473803,
0.056583025,
-0.013975956,
-0.0042319717,
-0.0036801172,
0.006338161,
0.033254936,
-0.003399292,
0.016536037,
0.0100117475,
0.0097701065,
-0.019997371,
-0.025457136,
0.06499472,
0.0054042535,
-0.02078107,
0.0032245924,
-0.00039980866,
-0.040177606,
-0.13552758,
-0.019409597,
0.0018025064,
0.03526643,
-0.0050450587,
-0.0072753336,
0.00013214706,
0.017267488,
0.00031837748,
0.033594538,
-0.01401514,
-0.015948262,
-0.008992939,
-0.023850555,
0.022335405,
-0.010841161,
0.016784208,
0.0018563856,
-0.015739277,
0.024216281,
-0.0067463373,
0.014080448,
0.015321304,
-0.0052671065,
-0.014302496,
0.008692522,
-0.036729332,
0.037304044,
0.021434152,
0.007125125,
-0.0033731686,
-0.009822354,
0.025574692,
-0.024660377,
-0.011788131,
0.0014343314,
0.005071182,
-0.024751808,
0.015504167,
-0.006416531,
-0.007223087,
0.010423189,
0.0296238,
-0.008986409,
0.00055307883,
-0.02499998,
-0.01122648,
-0.0011077904,
0.018025063,
-0.0057307947,
-0.035867263,
-0.015987448,
-0.041614387,
-0.0054499693,
0.0044638156,
-0.025901232,
0.025574692,
0.020741886,
-0.00067308266,
0.012199572,
0.0074255425,
0.00026755955,
0.003244185,
-0.00007173698,
0.0226097,
-0.011265664,
-0.027507814,
-0.04608147,
0.019762263,
-0.009907254,
0.0054597654,
0.002463752,
-0.0024604865,
-0.009254172,
-0.013329404,
0.002757639,
-0.031008335,
-0.017816078,
-0.00077471853,
-0.00058410026,
0.004689129,
-0.009828884,
0.0153604895,
-0.024033418,
0.034848455,
-0.030590361,
0.013179195,
-0.006148767,
0.0012310595,
-0.012833062,
-0.0039380845,
0.030485868,
0.006857361,
-0.015882954,
-0.016640529,
0.00009847252,
0.014550667,
0.0073145186,
0.020350035,
0.02628002,
0.0027772314,
-0.02618859,
-0.042816058,
0.005485889,
0.0013951465,
0.010135833,
-0.0168887,
0.009267234,
-0.0044180998,
-0.024150973,
-0.00569161,
0.017842202,
-0.028134773,
0.006266322,
0.0046140244,
-0.0059854966,
-0.009352135,
-0.02324972,
0.010495028,
-0.027011473,
0.013251035,
0.037513033,
-0.011330973,
0.0046074935,
0.008228834,
0.010403597,
0.013649414,
-0.019710016,
-0.022074172,
0.008032909,
0.0010881979,
-0.0030841797,
0.019775324,
-0.04370425,
-0.024712624,
-0.009515405,
-0.030642608,
-0.012317127,
-0.0075757513,
0.024059542,
0.007667183,
0.03654647,
-0.008542313,
-0.028735608,
0.01640542,
-0.0111872945,
-0.019997371,
-0.0019233265,
-0.018834885,
-0.00009000287,
0.011631391,
-0.00843782,
0.045585126,
0.011344034,
-0.0023772186,
-0.014302496,
-0.0009779903,
-0.013015925,
-0.028657239,
-0.007817391,
-0.020023495,
-0.02492161,
-0.004284218,
0.01504701,
0.032079387,
0.014341681,
-0.0048295413,
-0.011121986,
-0.034378238,
-0.013453489,
-0.0134273665,
-0.03591951,
-0.0100444015,
0.0039870655,
0.027821293,
-0.01123301,
0.011957931,
0.008555374,
-0.01601357,
0.0037454253,
0.00007010427,
0.011716291,
0.008372512,
-0.00804597,
-0.03223613,
0.0045095314,
0.030851595,
0.005430377,
-0.013571044,
0.0036115434,
0.027324952,
-0.0037878756,
-0.020415343,
0.024307713,
0.015229872,
0.010965247,
0.01528212,
0.020833317,
-0.022048049,
-0.004483408,
-0.006831238,
0.025274275,
0.0045062657,
-0.0039184922,
-0.0029845848,
-0.025666123,
-0.008483536,
0.017058503,
-0.041431524,
-0.044853672,
-0.0066026594,
-0.0060410085,
0.022021925,
0.011487713,
-0.0008694154,
-0.008490066,
-0.008424758,
0.043286275,
0.010279511,
0.0046858634,
0.004649944,
0.027847417,
0.037251797,
0.018286297,
-0.003686648,
0.011246072,
0.021068426,
0.008424758,
0.021368844,
-0.035736647,
0.028552746,
-0.03518806,
0.04036047,
-0.017110748,
-0.04571574,
-0.012597952,
-0.00971786,
-0.02985891,
0.015752338,
0.015896017,
-0.01824711,
0.06906995,
0.008072094,
-0.015896017,
0.010939124,
-0.004254829,
0.00073267636,
0.014446174,
0.015791522,
-0.014472297,
-0.0066026594,
0.033254936,
-0.015164564,
0.022479083,
-0.033150442,
-0.01792057,
0.013179195,
-0.007229618,
-0.016039694,
0.015935201,
-0.0053062914,
0.031086704,
-0.012323658,
-0.0097897,
0.027612308,
-0.030067896,
-0.0015673968,
0.040726196,
0.021185981,
0.019866755,
-0.035997882,
0.0045748395,
-0.007262272,
-0.036337484,
-0.019069996,
0.020911686,
-0.01114811,
-0.01489027,
-0.036912195,
0.006321834,
0.0090451855,
-0.019487968,
0.0060540703,
-0.0071381866,
-0.01775077,
0.01099137,
-0.017711584,
0.0059920275,
0.005009139,
-0.0033796995
] |
To appreciate the neural underpinnings of sleep, it is important to view this universal mammalian behaviour at multiple levels of its biological organization. Molecularly, the circadian rhythm of sleep involves interlocking positive- and negative-feedback mechanisms of circadian genes and their protein products in cells of the suprachiasmatic nucleus that are entrained to ambient conditions by light. Circadian information is integrated with information on homeostatic sleep need in nuclei of the anterior hypothalamus. These nuclei interact with arousal systems in the posterior hypothalamus, basal forebrain and brainstem to control sleep onset. During sleep, an ultradian oscillator | [
-0.015398821,
0.025112122,
0.015722597,
-0.034579355,
-0.020644004,
0.0025821193,
0.002225965,
-0.023221267,
-0.03657382,
-0.0023554757,
-0.009648547,
0.020760564,
0.0071619414,
0.0041540554,
-0.0068252133,
-0.013391405,
0.029787458,
-0.006792836,
-0.0039436007,
0.020281374,
-0.023532093,
-0.0050573926,
0.00024789156,
-0.015113898,
0.008243356,
0.022871587,
0.0014157137,
-0.034346234,
0.006190611,
-0.025940992,
0.010781765,
-0.010982507,
-0.0054718265,
-0.008942713,
0.020255473,
-0.013093531,
0.0014594236,
-0.006715129,
0.00080984656,
-0.008139747,
0.025578361,
0.019841038,
-0.015113898,
0.0000271163,
-0.02047564,
0.0030402634,
0.027585777,
-0.023946527,
-0.008249831,
0.02035908,
0.0054135467,
0.031989142,
-0.02616116,
-0.015411772,
-0.016085228,
-0.008165649,
0.00005929161,
0.03015009,
0.024024233,
-0.033232443,
0.006909395,
0.0002476892,
-0.017781818,
0.030564522,
0.0151398,
0.008955664,
-0.0010401327,
0.0060384357,
0.004613818,
-0.009842812,
0.047426816,
0.014725366,
-0.0049440707,
0.024982613,
0.012879838,
-0.011617109,
-0.012452452,
-0.0055042044,
0.005203092,
0.0011364563,
-0.0045296364,
-0.019594967,
-0.02518983,
0.013572721,
-0.0026258293,
0.0071748924,
-0.013087056,
0.013248944,
0.005737324,
0.016046375,
0.013520916,
0.019685624,
0.011280381,
-0.006035198,
-0.009169357,
0.0045814407,
0.0029188471,
0.0027051545,
-0.01731558,
-0.0042090975,
-0.010334953,
0.013585672,
-0.01889561,
-0.015800305,
-0.008437621,
-0.019957598,
0.0061711846,
-0.003979216,
0.0072396477,
-0.01290574,
-0.019051023,
0.03830926,
-0.0010814143,
-0.03672923,
-0.002101311,
0.0065823807,
0.010367331,
0.0107882405,
-0.0021547342,
-0.022198133,
0.030927153,
0.03077174,
0.026251817,
-0.00842467,
0.025928041,
0.024063086,
0.012989922,
-0.009421903,
-0.006494961,
-0.014000106,
-0.047219597,
0.0070583327,
-0.0027844799,
0.022068622,
-0.029476633,
0.0059154006,
0.0073238295,
0.00080175215,
-0.00999175,
-0.011377514,
0.017626405,
0.016758684,
-0.048385195,
-0.002614497,
0.013611574,
0.04807437,
-0.00015571636,
0.012096299,
-0.0021595908,
-0.0029237038,
0.032869812,
-0.016447857,
-0.009655022,
-0.0018600973,
0.0066438983,
0.018934462,
0.012005641,
0.034190822,
-0.010257247,
0.0049602594,
0.022625517,
-0.010671681,
0.015372919,
0.012232285,
0.024516374,
0.013443209,
0.025125073,
-0.0107752895,
0.0037493345,
-0.0023716646,
-0.0020268422,
0.000098296594,
-0.024568178,
0.02021662,
-0.026653301,
0.029373024,
0.00920821,
0.005326127,
-0.037273176,
-0.014090763,
-0.016577369,
-0.0014132854,
0.010043554,
0.006507912,
-0.014828974,
-0.01986694,
0.018196251,
-0.02508622,
0.009434854,
0.0023052902,
-0.026549691,
-0.023273071,
-0.015683744,
-0.029398927,
-0.6477607,
-0.018817903,
0.009467231,
-0.019530213,
-0.010464463,
0.011144395,
0.0036101106,
-0.0049343575,
0.01550243,
0.015347017,
-0.015657842,
0.012115725,
0.017004754,
-0.028207429,
-0.011034311,
-0.026679203,
-0.01683639,
-0.024814248,
0.018571833,
0.0034611733,
-0.011953836,
0.015839158,
-0.004494021,
0.0060449117,
-0.0011542641,
0.006426968,
0.03040911,
-0.023998331,
0.0046785735,
0.031937335,
-0.015321115,
0.0021773984,
0.010218393,
-0.015968667,
0.047064185,
-0.010017652,
-0.013546818,
0.020177765,
-0.006203562,
0.0290881,
-0.022275839,
-0.015929814,
0.034320332,
-0.0036942924,
-0.014142567,
0.0069935773,
-0.0015185128,
-0.021926159,
0.019944645,
-0.03400951,
0.028285135,
0.015463577,
-0.007621704,
0.0032183407,
0.001683639,
-0.0038788451,
0.019905793,
-0.015644891,
0.004079587,
0.009778057,
0.0027488645,
0.00001575882,
-0.010496842,
-0.0015946004,
-0.01697885,
0.019853989,
-0.012122201,
0.0037460967,
0.0029706515,
-0.0011825945,
-0.00060546247,
0.029398927,
-0.013754035,
0.022858636,
-0.0045846784,
0.01138399,
0.01949136,
0.0003587851,
-0.018027889,
0.02046269,
-0.009473707,
-0.002460703,
-0.016473759,
-0.021602383,
0.028000211,
-0.0051545254,
0.012633768,
0.025953943,
-0.0087484475,
-0.0077576903,
-0.013417307,
-0.011060213,
0.0057567502,
-0.02434801,
-0.025992796,
0.032170456,
-0.0009818529,
0.013028775,
-0.0041929088,
-0.017043607,
0.002310147,
-0.007531047,
-0.014155518,
-0.0020964544,
0.039578468,
-0.024542276,
-0.0037525722,
0.0035032642,
0.04325657,
-0.020877123,
-0.011882606,
-0.015087996,
-0.0024218499,
0.0061064293,
-0.011940885,
-0.011377514,
0.01817035,
0.015334066,
0.010619877,
-0.003687817,
-0.0066438983,
-0.004406601,
0.008301635,
-0.02326012,
0.019957598,
0.003380229,
-0.0047886577,
-0.020190716,
-0.029606143,
0.0018843806,
-0.0052678473,
-0.0030823543,
0.014388638,
-0.021421067,
-0.017535748,
0.02350619,
0.031548806,
-0.008074991,
0.01563194,
-0.041262105,
-0.009836337,
0.00204465,
-0.0109630795,
-0.008618937,
-0.0023554757,
-0.015437675,
-0.029114002,
0.01138399,
0.010263722,
0.01986694,
-0.011248004,
-0.019569065,
-0.015230457,
0.012400649,
0.023570945,
0.0025076508,
-0.027689386,
-0.013048202,
-0.01708246,
-0.0027521022,
0.014984387,
0.02774119,
-0.03538232,
0.0072785006,
-0.0205922,
-0.014816023,
-0.00020337226,
0.010801191,
-0.0025578362,
-0.02859596,
0.000063794134,
0.0042641396,
-0.0055851485,
0.013313699,
0.026834615,
0.001496658,
-0.00084748556,
-0.030435013,
-0.016020473,
-0.004908455,
0.00829516,
0.018727247,
-0.010211918,
-0.0010984126,
0.022755029,
0.032740302,
0.045510057,
0.0004957831,
0.0007333543,
0.004144342,
-0.001934566,
0.03841287,
-0.023467338,
-0.007375634,
-0.010393233,
-0.037843022,
0.0181833,
-0.010140687,
0.021576481,
0.014699464,
0.002336049,
-0.024063086,
-0.0051545254,
-0.017406236,
0.0010741292,
-0.0120639205,
0.01817035,
-0.009052797,
-0.0036327748,
-0.0046785735,
-0.00085558,
-0.0034061312,
0.005271085,
-0.011040786,
-0.0045296364,
0.02205567,
-0.007835397,
0.003992167,
-0.017160166,
0.005371456,
-0.00063581654,
0.006190611,
0.019452505,
0.0013582434,
0.001253016,
0.023687506,
-0.0038302788,
0.012141627,
0.024192598,
-0.009739204,
-0.004817798,
0.013974204,
-0.03139339,
0.03444984,
0.016227689,
0.019271191,
-0.003574495,
-0.009765106,
0.016668025,
0.024632933,
0.0026193538,
0.016939998,
0.012141627,
-0.016784586,
0.007964907,
-0.0052419454,
0.005624002,
0.01538587,
-0.023920624,
-0.03426853,
-0.006077289,
-0.010982507,
-0.038827304,
0.00042617111,
0.0126013905,
0.0021903496,
-0.008644839,
-0.013546818,
0.027896604,
0.017380334,
-0.0005581101,
0.009247064,
-0.00024890335,
-0.031471096,
-0.01902512,
-0.0043353704,
0.023894722,
-0.015321115,
-0.017535748,
-0.0044584055,
-0.019284142,
0.013443209,
-0.0054135467,
-0.024581129,
0.04569137,
-0.00042131447,
-0.009247064,
0.014116665,
0.036884643,
0.011999166,
-0.027456267,
-0.01265967,
-0.006883493,
0.022198133,
-0.006339548,
0.006009296,
-0.01708246,
0.008165649,
0.0045620142,
-0.012458929,
-0.0040051183,
-0.008288684,
-0.010024128,
-0.02763758,
0.012549586,
-0.0131647615,
0.018558882,
0.0081786,
0.008780825,
-0.00848295,
-0.0035032642,
0.023039952,
-0.010075931,
-0.0083987685,
0.020255473,
0.00017848192,
0.01841642,
-0.0024542275,
-0.0027569588,
-0.0130223,
-0.005611051,
-0.0062424154,
0.009946421,
-0.026148207,
0.0054005957,
0.008690167,
-0.003742859,
0.010529219,
0.00059777277,
-0.0032312917,
-0.014362736,
-0.0061129048,
-0.014077812,
-0.0056175264,
0.031548806,
0.013948302,
-0.017354432,
0.031678315,
-0.0057567502,
0.001934566,
-0.03659972,
-0.03426853,
0.02942483,
-0.011345137,
0.008884434,
-0.014272078,
-0.010593974,
0.0022486295,
0.017030656,
0.009214685,
0.0083858175,
-0.001434331,
0.0030078858,
0.031548806,
0.006290982,
-0.013100007,
0.00073456846,
0.045251034,
0.02350619,
-0.01769116,
0.013883546,
0.02156353,
-0.00745334,
-0.043386083,
-0.00095352245,
0.016745733,
0.004238237,
0.03571905,
-0.020553347,
-0.011416367,
-0.0021272132,
-0.01308058,
-0.0068770177,
0.0014699463,
0.009803959,
0.02737856,
0.01405191,
-0.017393285,
0.009603217,
-0.0023020525,
0.021058438,
0.021757796,
-0.015916863,
-0.009117553,
0.00861246,
-0.011196199,
-0.008871483,
-0.01804084,
0.006161471,
0.0040245447,
-0.010937178,
0.0008312967,
0.019478409,
-0.0077317883,
-0.01721197,
-0.009098126,
0.021226803,
-0.009065748,
0.005484778,
-0.0042900415,
0.0326885,
-0.00970035,
-0.025759676,
-0.0045134476,
-0.0044001257,
-0.03367278,
-0.016901145,
0.0087484475,
0.03732498,
0.008469999,
0.020449737,
-0.016655074,
0.007621704,
0.012484831,
-0.008767874,
-0.011105542,
-0.0044357413,
-0.0051383367,
0.014893729,
0.0013954777,
0.028492352,
-0.019115778,
0.020553347,
-0.01997055,
0.021654187,
0.0001795949,
0.042246386,
0.00466886,
-0.0019798947,
0.031833727,
0.0155283315,
0.03864599,
0.021006634,
-0.016668025,
0.0038011388,
-0.017030656,
-0.004649434,
-0.0067993114,
0.00751162,
-0.028052015,
-0.0034158444,
0.01914168,
-0.023687506,
-0.003145491,
0.010574548,
-0.026549691,
0.0016804012,
0.018882658,
-0.0077317883,
-0.0008499139,
-0.02919171,
0.022249937,
-0.016098179,
-0.015204555,
-0.004325657,
-0.009331245,
0.0212009,
0.017639356,
-0.012128676,
0.011027835,
-0.00025881903,
0.008431146,
-0.012627292,
-0.0012675859,
-0.01770411,
0.0605592,
0.0039176983,
-0.05501614,
-0.015670793,
-0.008217453,
-0.016227689,
0.00005792568,
-0.012938118,
-0.0012999636,
0.0036522015,
-0.00503149,
0.003226435,
-0.030357305,
0.027559875,
-0.034087215,
0.01634425,
-0.009059273,
-0.007822446,
0.022547811,
-0.01722492,
-0.0107882405,
-0.022262888,
-0.009428378,
0.015657842,
-0.054290883,
-0.00005873512,
-0.009784533,
0.06346024,
0.023519142,
0.013482063,
0.011254479,
0.0013954777,
0.036806937,
0.0157485,
-0.009292392,
-0.010082407,
0.0029512248,
-0.0218096,
0.02349324,
-0.0016059326,
-0.0055042044,
0.013223042,
0.010872423,
0.030020578,
0.027767092,
0.0071295635,
-0.046805162,
-0.023674555,
-0.0087484475,
-0.02568197,
0.017199019,
-0.023842918,
0.0021612097,
-0.026070502,
-0.01722492,
0.035356417,
0.031445194,
0.01550243,
-0.05291807,
0.021550579,
-0.037221372,
0.036003973,
-0.01780772,
0.03235177,
-0.026990028,
-0.01006298,
-0.029735655,
-0.0034320334,
0.022483056,
-0.0015897438,
0.0050994833,
0.022262888,
-0.005734086,
-0.003338138,
-0.0011380751,
-0.022742078,
-0.0081786,
-0.019957598,
-0.0071748924,
-0.02846645,
-0.0026484935,
-0.0388014,
-0.010160114,
-0.004574965,
0.031082565,
-0.011034311,
0.03162651,
-0.025047367,
-0.006987102,
0.012433026,
-0.019452505,
0.026497887,
-0.010827093,
0.035304613,
0.008126796,
-0.0024914618,
0.001078986,
-0.019685624,
-0.010568072,
-0.001976657,
0.03587446,
0.010121261,
-0.0058765477,
-0.008321062,
0.0077706412,
0.013741084,
0.0052937493,
-0.015929814,
0.007654082,
0.0062812683,
-0.004591154,
-0.018092643,
-0.022949295,
0.013203615,
0.011759571,
-0.015968667,
0.005271085,
-0.01290574,
0.003852943,
-0.03185963,
0.043800514,
-0.009758631,
0.009059273,
0.015839158,
0.012329417,
0.002449371,
0.014129616,
-0.02243125,
0.0012562537,
0.009447805,
0.01779477,
0.00026650872,
-0.007343256,
0.0032410051,
-0.014310931,
0.01612408,
-0.010380282,
-0.025202781,
0.04203917,
-0.016655074,
-0.012892789,
0.0056822817,
0.01780772,
0.015308164,
-0.016434906,
-0.011999166,
0.015593087,
-0.020890074,
0.008308111,
0.0062780306,
0.02397243,
-0.008392293,
-0.0148030715,
-0.013417307,
-0.025034416,
-0.0169659,
0.0075051445,
-0.0038043766,
-0.031108467,
0.011170297,
-0.008871483,
0.016745733,
0.028077917,
0.0083987685,
-0.020915976,
-0.00472714,
0.020035304,
-0.0054524,
0.033102933,
0.003966265,
0.018351665,
-0.017173117,
0.00047149986,
-0.021511726,
-0.0351492,
0.026122306,
-0.01393535,
-0.030435013,
-0.006064338,
0.009894617,
0.01925824,
-0.00057713204,
0.0070712836,
0.006818738,
0.004043971,
0.011202674,
0.006967675,
-0.024127841,
0.0061064293,
-0.023519142,
-0.012290564,
0.021667138,
-0.029036297,
0.0077771167,
-0.003742859,
-0.009408952,
0.012562537,
-0.017820671,
0.0109048,
-0.015916863,
0.014388638,
-0.005908925,
-0.005883023,
-0.0029722704,
-0.006592094,
-0.023182414,
0.02469769,
-0.020255473,
0.004079587,
-0.018066742,
-0.013844693,
-0.0027051545,
0.026122306,
0.014026008,
0.026018698,
0.026212964,
-0.052374125,
-0.040303726,
-0.018364616,
-0.022612566,
0.03587446,
0.011759571,
-0.0012271138,
0.00861246,
-0.0024105178,
-0.018390518,
-0.017302629,
0.03805024,
0.028259233,
0.0020818843,
-0.0059477785,
0.011597683,
0.0018827617,
0.005228994,
0.009784533,
-0.011740144,
-0.006371926,
0.025824431,
0.0060384357,
0.021822551,
-0.0050185393,
-0.010024128,
0.015450626,
0.010872423,
-0.020203669,
-0.015243408,
0.0067669335,
-0.012193431,
0.024270304,
0.025617214,
0.010535695,
-0.012743852,
0.018338714,
0.010995458,
0.00063015043,
-0.00014913965,
-0.005805317,
-0.023829967,
-0.02326012,
-0.005228994,
0.010976031,
0.020501543,
0.0064787725,
-0.03913813,
-0.021887306,
0.020540396,
-0.035097398,
0.018934462,
0.021654187,
0.011079639,
0.014893729,
-0.003975978,
-0.017432138,
-0.021693042,
-0.016486712,
0.010224869,
0.01454405,
0.0091369795,
-0.003911223,
0.009188783,
0.025448851,
0.008605985,
-0.029269416,
0.0017143978,
-0.011461696,
0.011396941,
-0.029165808,
0.011228577,
0.008463523,
0.0031260643,
0.019374799,
-0.018131496,
-0.009441329,
-0.010140687,
0.006261842,
-0.0120509695,
0.0035421173,
0.021628285,
0.0014375687,
-0.0037007679,
0.009408952,
-0.015593087,
0.0038756074,
-0.019815136,
0.0024169933,
0.17976084,
-0.017147215,
0.0031519665,
0.005093008,
-0.016927047,
-0.011733669,
0.016758684,
0.00957084,
-0.00050023507,
0.013844693,
-0.014375687,
0.0151657015,
-0.017496895,
-0.0023732835,
-0.0055689598,
-0.047996663,
-0.028906787,
0.007304403,
0.0013436734,
0.004419552,
0.0013420546,
-0.03476067,
-0.027456267,
-0.010639303,
0.039086327,
0.01271795,
-0.018248057,
-0.010309051,
0.0041281534,
0.02278093,
-0.02095483,
0.012925167,
-0.013870595,
0.00617766,
-0.022379447,
0.008392293,
0.0033284246,
-0.008923287,
-0.013702231,
-0.0071748924,
-0.00048890285,
-0.0023004336,
-0.009350671,
-0.012348845,
0.02797431,
0.016137032,
0.0059736804,
-0.010840044,
-0.000035539553,
0.01550243,
-0.0484629,
0.0018471462,
0.02724905,
0.03426853,
0.005604575,
0.009732729,
0.0199835,
0.022301741,
-0.0019038072,
0.029010395,
-0.023752261,
0.016901145,
-0.020333178,
0.016952949,
0.00014822904,
0.018494127,
-0.029398927,
0.021252705,
0.042375896,
-0.017548699,
-0.007498669,
-0.013831742,
-0.03659972,
-0.009428378,
0.0012287326,
0.00017838074,
0.03126388,
0.02566902,
-0.0023279546,
0.04372281,
-0.011785473,
-0.0028589484,
-0.023169462,
-0.0054750643,
0.0087484475,
-0.046934675,
0.016137032,
0.014349785,
-0.0020559821,
-0.010004701,
0.007951956,
-0.0047498047,
0.009952896,
0.0059445407,
0.005465351,
-0.031186175,
0.019556114,
0.006818738,
-0.0030548335,
-0.018105594,
-0.01671983,
0.035667244,
0.031497,
0.030460915,
-0.017095411,
-0.013857644,
0.0052192807,
0.011416367,
0.022340594,
-0.010490366,
-0.0022065383,
-0.011558829,
0.017419187,
-0.017419187,
-0.004885791,
0.02955434,
0.01805379,
-0.03452755,
0.009201734,
-0.019076925,
-0.016952949,
-0.017250825,
0.0011785473,
0.01795018,
-0.013009349,
-0.0151786525,
-0.013352552,
0.003325187,
0.017522797,
-0.04628712,
0.020410884,
-0.008683692,
-0.0009502847,
-0.016020473,
0.0013023919,
-0.017924279,
0.015580136,
-0.0026274482,
0.002028461,
0.015903912,
-0.014349785,
0.012374747,
0.0035226909,
0.009182308,
-0.00067426503,
-0.013106482,
0.014375687,
0.014971436,
-0.02278093,
-0.00058725005,
-0.0067410315,
-0.0061517577,
0.033025227,
-0.020579249,
0.012653194,
-0.014129616,
-0.023454387,
-0.03595217,
-0.0068381643,
-0.012271138,
-0.015644891,
-0.009680924,
-0.008618937,
-0.014323883,
0.006543528,
0.018869707,
-0.16080047,
-0.00037214087,
0.023959478,
-0.020553347,
0.0067410315,
0.01490668,
-0.0033478513,
0.02034613,
-0.013870595,
-0.005093008,
0.013870595,
0.013125909,
-0.039811585,
-0.03380229,
0.0040374957,
0.019776283,
-0.015463577,
0.03053862,
-0.007233172,
0.013456161,
0.018636588,
-0.023661602,
0.017678209,
-0.014738317,
0.0072396477,
0.013792888,
0.019322995,
0.0023878533,
-0.00962912,
-0.032066848,
-0.009188783,
0.002504413,
0.007971383,
-0.0017678209,
0.042220484,
-0.00654029,
-0.017535748,
-0.010198967,
-0.013074104,
0.014880778,
0.016927047,
0.0082239285,
0.0044357413,
0.04095128,
-0.007427438,
0.014155518,
0.0010943654,
-0.0013655283,
-0.009350671,
-0.020812368,
-0.0058765477,
0.0144274905,
-0.008249831,
0.00021854929,
-0.0007357826,
0.0068640667,
-0.0017224922,
-0.002506032,
0.00035453553,
-0.013074104,
0.006022247,
-0.026990028,
0.031963237,
0.0055009667,
0.00022320358,
-0.015813256,
-0.010956604,
0.015411772,
-0.009803959,
0.0052678473,
-0.017354432,
-0.013248944,
0.0070712836,
-0.029502535,
0.025617214,
0.0065500033,
-0.006537052,
0.0013169618,
-0.00890386,
0.0016820201,
-0.00945428,
0.014038959,
-0.026575593,
-0.009292392,
-0.009603217,
-0.020928927,
0.0077317883,
0.04071816,
-0.00005433378,
0.008605985,
0.016059326,
-0.02218518,
0.017548699,
-0.0009761868,
0.028673667,
-0.0163572,
0.034190822,
-0.015087996,
0.01852003,
0.021019585,
0.010768814,
-0.006870542,
-0.0100370785,
0.019594967,
0.027404463,
0.0016609746,
-0.022651419,
-0.014233225,
0.030098284,
-0.022107475,
-0.0011356468,
-0.01950431,
0.0024866052,
0.019193484,
-0.008165649,
0.032325868,
0.0072396477,
-0.010833569,
-0.0032523372,
-0.023467338,
0.06641308,
0.015282261,
-0.020967782,
0.02070876,
-0.011481123,
-0.044655286,
-0.13479473,
-0.03004648,
0.0033575646,
0.024671787,
-0.0031924385,
0.015606038,
-0.006524101,
0.026653301,
-0.0068381643,
0.035097398,
-0.011066688,
-0.021291558,
-0.0007220221,
0.0011688339,
0.014388638,
-0.0028459975,
0.0063201217,
-0.0151786525,
-0.0109630795,
0.029398927,
0.007375634,
0.00403102,
-0.009655022,
0.01193441,
0.0031924385,
0.0026630636,
-0.029735655,
-0.0028961827,
0.02605755,
0.0004723093,
-0.015994571,
-0.009260015,
0.0029593194,
-0.013909448,
-0.010309051,
-0.01914168,
-0.023557995,
-0.03087535,
0.036755133,
-0.01368928,
-0.008703118,
0.016499663,
0.026225915,
0.005860359,
0.0063686883,
-0.010322002,
-0.018882658,
-0.0004067445,
0.0107882405,
-0.0151786525,
-0.006064338,
-0.008696643,
-0.031963237,
-0.033854093,
0.019763332,
0.0071295635,
0.0060416735,
0.0124395015,
-0.0077965437,
-0.00018131497,
0.022884538,
0.0218096,
-0.01889561,
0.0032652882,
0.008981566,
-0.020177765,
-0.02423145,
-0.028155625,
0.02810382,
-0.002588595,
-0.0017192544,
0.025280487,
-0.008314586,
-0.003158442,
-0.015903912,
0.010548646,
-0.018001987,
-0.017768867,
-0.007900152,
0.011914983,
-0.0051124343,
-0.0041993842,
0.019335946,
-0.0049861614,
-0.0032215784,
0.00445193,
0.0042770905,
0.008262782,
-0.011681864,
0.011027835,
-0.012445977,
0.02278093,
0.019310044,
-0.025293438,
-0.004863126,
-0.004296517,
-0.01441454,
-0.005047679,
0.010736437,
0.026212964,
-0.006941773,
-0.0027650532,
-0.031160273,
0.014997338,
0.00083534396,
0.0056531415,
0.0224183,
-0.014116665,
0.035330515,
-0.013624525,
-0.009240588,
-0.00058927364,
-0.0035388796,
0.0008596272,
-0.012925167,
0.002823333,
-0.037506297,
-0.015567185,
0.035175104,
-0.009007469,
0.010509793,
0.013559769,
-0.016862292,
-0.0029415116,
0.008068516,
0.025759676,
-0.010315526,
-0.016642123,
0.005912163,
0.0038594187,
-0.014699464,
0.007803019,
0.019167582,
-0.023415532,
-0.0122258095,
0.008502377,
-0.017639356,
-0.028854981,
-0.007291452,
0.021783698,
0.03416492,
0.03224816,
-0.030564522,
-0.040536847,
-0.0029415116,
-0.030486817,
0.0151786525,
0.0014658992,
-0.039448958,
0.0034708865,
-0.010911276,
-0.008767874,
0.033465564,
0.025293438,
0.001258682,
0.008793776,
-0.013546818,
0.009408952,
-0.010587499,
-0.009169357,
-0.02518983,
-0.019128729,
0.005769701,
0.033595074,
0.0071166125,
-0.013119433,
-0.01466061,
-0.011254479,
-0.04084767,
-0.013482063,
-0.0032410051,
0.0033543268,
-0.016447857,
0.010432086,
0.033646878,
0.0014310931,
0.0043450836,
-0.016771635,
-0.019944645,
-0.014738317,
-0.019672673,
0.0006038436,
0.03087535,
0.013015824,
-0.012750328,
0.0041378667,
0.03841287,
0.0010457989,
-0.022198133,
0.034061313,
0.020320227,
0.006702178,
0.00023008384,
-0.0039695026,
0.03113437,
0.008191551,
0.013792888,
0.020618102,
-0.023078805,
-0.00028836363,
-0.0025999271,
0.033750486,
0.0055851485,
0.014634708,
0.0017597266,
-0.047219597,
-0.020242522,
0.030020578,
-0.029839262,
-0.026627397,
0.00029200612,
0.009531987,
-0.0122387605,
0.008690167,
0.015515381,
0.0013048202,
-0.013637476,
-0.014013057,
-0.0055139177,
0.011856704,
-0.019841038,
-0.020903025,
0.0078094946,
0.00035655912,
0.010464463,
0.0022583427,
-0.0018859995,
0.00080053793,
0.013087056,
-0.023596847,
0.03188553,
0.0030645467,
0.003032169,
-0.017626405,
-0.018105594,
-0.0073821093,
-0.031833727,
-0.019219387,
0.00008195599,
0.012957545,
-0.0034967887,
0.062579565,
0.008379342,
-0.015191604,
0.016227689,
-0.030616328,
0.023907673,
-0.0074080117,
0.005591624,
-0.03587446,
-0.0025497417,
0.023726359,
-0.01502324,
0.035693146,
-0.04797076,
-0.010930702,
0.029139906,
0.007654082,
0.009052797,
0.027585777,
-0.015295212,
0.023195365,
-0.017885426,
0.00037477157,
0.0017840097,
-0.03369868,
-0.0045717275,
0.026756909,
0.0087873,
0.0036198238,
-0.038257457,
0.015890962,
-0.0125884395,
-0.026679203,
0.008366391,
-0.0041281534,
0.0010344667,
-0.011183248,
-0.02495671,
0.0074339136,
0.03175602,
-0.003963027,
0.01779477,
-0.014466344,
0.0006135569,
-0.015347017,
0.006498199,
0.008010237,
-0.0082239285,
-0.021939112
] |
Aberrant gene silencing accompanied by DNA methylation is associated with neoplastic progression in many tumors that also show global loss of DNA methylation. Using conditional inactivation of de novo methyltransferase Dnmt3b in Apc(Min/+) mice, we demonstrate that the loss of Dnmt3b has no impact on microadenoma formation, which is considered the earliest stage of intestinal tumor formation. Nevertheless, we observed a significant decrease in the formation of macroscopic colonic adenomas. Interestingly, many large adenomas showed regions with Dnmt3b inactivation, indicating that Dnmt3b | [
-0.026975174,
-0.010160782,
0.007061109,
-0.031450994,
-0.048739687,
0.033374928,
-0.0315846,
0.0036875422,
-0.0062795104,
0.020375006,
0.03179837,
0.01051484,
0.011363242,
-0.005564715,
-0.0055379937,
0.012859635,
0.04919395,
-0.013434144,
-0.0013945189,
0.018891973,
-0.050636902,
0.035539355,
0.012619143,
-0.024450008,
0.007368404,
0.024810746,
0.012158201,
-0.061352152,
-0.010214224,
-0.010501479,
0.0133606605,
0.004733014,
0.00022024213,
-0.014683366,
0.0037810667,
0.0006396416,
0.010461397,
-0.01965353,
0.013126848,
-0.024329761,
0.0026437405,
0.016700825,
0.0028358002,
0.006947543,
-0.016527137,
-0.0028190992,
0.010427996,
-0.0149238575,
-0.012331889,
-0.0038612308,
0.0016734226,
0.015498365,
-0.023554843,
-0.001336066,
-0.019560006,
0.002242921,
0.007388445,
0.020321565,
0.0025819475,
0.004900022,
0.0014003642,
-0.007181355,
-0.028885746,
0.024944352,
-0.00445244,
-0.0069742645,
-0.0051939567,
-0.0016492065,
-0.004409018,
0.013594472,
0.03300083,
0.020936154,
-0.018143777,
-0.021203367,
0.014108857,
-0.01662066,
-0.023701811,
0.011650495,
-0.013454185,
0.011964471,
0.02145722,
-0.010040536,
0.007408486,
0.022419188,
0.025839517,
0.009699839,
-0.01577894,
-0.011283077,
0.012118119,
0.010394594,
0.022432549,
0.033027552,
0.019065661,
0.022632958,
-0.015057464,
0.014269185,
-0.0041651856,
0.03639444,
0.01821058,
-0.0065467237,
-0.029607223,
0.02205845,
0.0025652468,
-0.009733241,
-0.011577012,
0.0037743864,
0.013173611,
0.008871478,
0.02593304,
-0.01699476,
-0.018691564,
0.011443405,
-0.0011114399,
-0.03214575,
0.027215665,
-0.0007753358,
0.031638045,
0.0063863955,
-0.004572686,
0.000008324318,
0.014803612,
0.03444378,
0.026881648,
-0.022325663,
0.011870947,
0.013066726,
-0.0047062924,
0.0029877776,
-0.012231684,
-0.004529264,
0.016366808,
0.019586727,
0.018317465,
0.012719348,
-0.025398614,
0.022686401,
-0.009886889,
-0.026213614,
-0.041818865,
-0.04294116,
0.005224018,
0.019372957,
-0.023915581,
-0.0125657,
-0.0029193042,
0.025358533,
0.023180746,
0.0054745306,
-0.0037677062,
-0.002794048,
-0.019987548,
-0.034737717,
-0.009065208,
-0.019586727,
0.004231989,
0.015351399,
0.010715249,
0.01962681,
-0.012866315,
0.0012057995,
0.001175738,
0.0024032488,
0.011109388,
0.007822666,
0.02875214,
0.027603123,
0.0036741814,
-0.0126391845,
-0.023715172,
-0.036100503,
0.014563119,
0.021524023,
-0.03182509,
0.012017914,
-0.02390222,
0.0091253305,
-0.010721929,
0.037169356,
-0.012839594,
-0.022566155,
-0.02265968,
0.022526072,
0.005541334,
0.0040783416,
-0.021190006,
-0.0024850827,
0.002693843,
-0.008838077,
-0.013207013,
-0.009325741,
-0.008477339,
-0.002855841,
-0.002855841,
-0.008597584,
-0.6297681,
-0.011216274,
0.010848856,
-0.01275943,
0.0014103847,
0.029206403,
0.010013815,
0.002000759,
-0.009472708,
0.0107954135,
-0.021924844,
0.018958777,
0.02346132,
-0.021069761,
0.0021159945,
-0.032893945,
-0.0052306983,
-0.0008559173,
0.025812795,
-0.0047396943,
-0.026614435,
-0.0021744475,
-0.006052379,
0.009218856,
-0.009245576,
0.013975251,
0.010641766,
0.006920822,
0.007555453,
0.014322627,
-0.03056919,
0.01377484,
-0.023381155,
-0.0058786906,
0.04232657,
0.0034938126,
0.017181808,
0.02147058,
0.010381233,
0.010247626,
0.011376602,
-0.011009184,
0.019519925,
0.015017382,
-0.022913532,
0.028244436,
0.0077358223,
-0.008457297,
0.012518939,
-0.025745992,
-0.01195111,
0.0125523405,
-0.040162142,
-0.019813858,
0.015124267,
0.018250661,
0.033214603,
-0.010534881,
0.022298941,
0.0016867833,
0.021751154,
0.031477716,
-0.0069542234,
-0.024530172,
-0.011369921,
-0.006005617,
-0.015725497,
-0.0028525009,
-0.0035973578,
-0.0067571537,
0.010227585,
0.014482955,
0.0016558868,
0.0026270398,
0.026186895,
0.040776733,
-0.009532831,
0.0016300005,
-0.008276929,
0.023635007,
0.009172093,
-0.003707583,
-0.020976236,
0.0025786073,
0.034336895,
-0.0068540187,
-0.005023608,
0.020789187,
-0.013100127,
-0.0018972137,
0.018557956,
0.006947543,
-0.018985499,
-0.03989493,
-0.009893569,
-0.004779776,
-0.008056478,
0.0038578906,
-0.0053108623,
-0.011343201,
-0.026173534,
0.0091787735,
0.017716235,
0.0016199801,
0.015819022,
-0.010093979,
-0.03398952,
0.011697258,
0.03666165,
0.0012976541,
0.010915659,
0.006376375,
-0.025465418,
-0.011777421,
-0.016473694,
-0.007000986,
0.01214484,
-0.009646396,
-0.025652468,
-0.018905334,
0.0114100035,
0.00016721702,
0.0042887717,
-0.00015719651,
0.002450011,
-0.011650495,
0.028190993,
-0.0036908824,
0.0037510053,
-0.011383282,
-0.0012450465,
-0.0029126238,
0.010548241,
-0.03139755,
0.013621193,
-0.006419797,
0.019813858,
-0.008210125,
-0.00077032554,
-0.023220828,
-0.031130338,
-0.00007452743,
0.00909861,
0.00890488,
-0.0020542014,
0.002653761,
-0.008337052,
0.0009152052,
-0.0039514154,
-0.0018103694,
-0.007261519,
0.007829347,
-0.00015761403,
0.026146812,
0.0076022157,
-0.008470658,
-0.015672054,
-0.030489026,
-0.005925453,
-0.008390495,
0.00992029,
0.0063529937,
0.006336293,
-0.010307749,
-0.016754268,
-0.018477794,
-0.0019473162,
-0.002047521,
-0.0007811811,
-0.007388445,
-0.00262871,
-0.0053943666,
-0.012819554,
-0.01620648,
-0.011015864,
0.0070210267,
-0.015845742,
0.0072347973,
-0.019346235,
0.0011548621,
0.002404919,
-0.011496848,
0.008924921,
0.0026821524,
0.05729051,
-0.0005928793,
0.011964471,
-0.0088982,
0.011897668,
0.029046075,
-0.011503528,
0.015631972,
-0.009031806,
-0.005080391,
0.008757913,
-0.024049189,
0.031210503,
0.012098078,
-0.0010546572,
0.045666736,
0.004081682,
-0.015364759,
-0.004068321,
-0.027362632,
0.035726406,
-0.016219841,
0.0017903284,
-0.01722189,
0.0059955963,
-0.0033936077,
-0.024196155,
0.011703938,
-0.0049267435,
-0.0016132997,
0.0030295297,
-0.0013920137,
-0.014509677,
-0.011470127,
0.0034804519,
-0.0068072565,
-0.01092234,
0.010140741,
-0.0011398313,
-0.009673118,
0.0026738022,
0.009866848,
0.004933424,
0.005307522,
0.008363773,
-0.033455092,
-0.014883775,
0.02915296,
-0.016954677,
-0.007648978,
0.006316252,
0.01517771,
-0.011363242,
-0.0010488118,
0.029660664,
0.0011481817,
-0.016340088,
0.0027556361,
0.023822056,
0.0011072647,
0.013006602,
-0.01557853,
0.025398614,
0.01760935,
-0.00910529,
0.0043054726,
-0.0129398,
0.0066970307,
-0.008557503,
-0.023768615,
0.0070210267,
-0.02674804,
0.0042152884,
0.017021481,
0.056649197,
0.0067872154,
0.013641234,
0.0011222954,
0.004749715,
-0.021978285,
0.007849388,
-0.00789615,
0.03134411,
-0.00971988,
0.011156151,
-0.00001278657,
-0.0142023815,
0.0032466403,
0.006780535,
-0.048766408,
0.015110906,
-0.0022729824,
0.008597584,
0.0251314,
0.01903894,
0.015672054,
0.0005832763,
-0.044838376,
0.03607378,
0.023862138,
-0.012238365,
-0.00022086842,
-0.028992632,
-0.009365823,
-0.00042628855,
-0.0020491912,
0.0057384036,
0.021617549,
0.00015458702,
0.009185454,
-0.012338569,
-0.017729595,
0.020361645,
-0.004499202,
0.017836481,
-0.018477794,
0.002085933,
-0.009592954,
-0.025238287,
0.0014746828,
0.021123204,
0.0072347973,
-0.0009602974,
-0.005708342,
-0.027202304,
-0.016326727,
-0.0070343874,
-0.001376983,
0.004996887,
-0.0047530546,
-0.024650417,
-0.004736354,
0.018277382,
0.011931069,
0.02124345,
0.0063195922,
-0.03014165,
-0.02367509,
-0.0031881875,
0.010067257,
0.0041952473,
0.03241296,
-0.015458284,
0.017903285,
0.0037944275,
0.026066648,
-0.0018905334,
-0.020521974,
0.030916568,
-0.0186114,
-0.0125523405,
0.031210503,
-0.003116374,
-0.011096029,
0.0097933635,
0.020548696,
-0.0015473315,
-0.02368845,
-0.01658058,
-0.00013809495,
-0.019132465,
0.0008934941,
0.04005526,
0.04491854,
0.010254307,
-0.017449021,
-0.011436725,
0.027897058,
0.010080618,
-0.0075487727,
0.006516662,
0.0020558715,
0.002915964,
0.022192057,
0.01662066,
-0.023915581,
-0.0030278596,
0.010635085,
-0.007415166,
-0.006777195,
0.033348206,
0.02245927,
0.016714185,
-0.0072949203,
0.0008951642,
-0.0064899405,
-0.012819554,
-0.0011506869,
0.013454185,
-0.011483488,
0.002286343,
-0.028431484,
-0.008163364,
-0.0023598266,
0.02184468,
0.024797386,
0.003198208,
0.008524101,
0.012064676,
0.00075111963,
-0.0073016006,
-0.0061793053,
0.0061993464,
0.00506035,
-0.0037610258,
-0.013614513,
-0.015164349,
-0.0022128592,
-0.015925907,
-0.0069876253,
0.002306384,
-0.017261973,
-0.030729517,
0.0047897967,
0.008437257,
0.020815909,
0.010427996,
-0.02589296,
0.013694677,
0.055580344,
0.002794048,
-0.016727546,
0.0014237453,
0.0024733923,
0.020802548,
-0.010975782,
0.0015865784,
-0.0069876253,
-0.034149848,
0.0033117735,
-0.010595003,
-0.014389431,
0.0030445603,
-0.002772337,
-0.012331889,
0.0019139146,
0.003258331,
0.03177165,
0.012826234,
-0.0076422975,
0.000047466878,
-0.012017914,
-0.048044935,
-0.01477689,
-0.015217792,
-0.020628858,
0.0058252476,
0.0062861904,
-0.014229103,
-0.013855005,
-0.0010613374,
-0.018143777,
-0.010367872,
-0.0022963635,
0.033080995,
0.04235329,
0.0058887107,
0.037383128,
-0.00708783,
-0.0046261284,
0.0014888785,
-0.027656566,
0.021564106,
0.009739921,
-0.020762466,
0.010915659,
-0.003118044,
-0.0033551957,
-0.021190006,
-0.004191907,
0.001640856,
0.025639107,
0.0026955132,
-0.02125681,
-0.03316116,
-0.0040616407,
0.00019070254,
-0.0025418657,
-0.009158732,
-0.023327712,
-0.009051847,
0.0064030965,
0.0049735056,
-0.009552872,
0.020334926,
-0.03316116,
0.0023965684,
0.02875214,
0.004763075,
-0.0037376448,
0.020762466,
0.0062861904,
-0.0266946,
-0.007448568,
-0.0048933416,
-0.028912468,
0.014843693,
-0.015191071,
0.02835132,
0.03380247,
0.03476444,
0.015351399,
0.031130338,
0.021564106,
0.015752219,
0.0055379937,
-0.0035906774,
0.03903985,
-0.019586727,
-0.015444923,
0.008797995,
0.0024650418,
0.030756239,
-0.016968038,
0.023862138,
0.004235329,
-0.01557853,
-0.023541482,
0.0182373,
-0.041150834,
-0.033775747,
-0.00566158,
0.000014234844,
0.016968038,
-0.037543453,
-0.010775372,
0.033294763,
0.035913453,
0.010962422,
-0.019466482,
0.019372957,
0.0006413117,
0.03887952,
0.00011429627,
-0.008477339,
-0.0014738478,
-0.010301069,
0.01642025,
-0.0096530765,
0.0020391708,
-0.020268122,
0.02411599,
0.01072861,
-0.025425335,
0.0035338947,
0.013574431,
-0.034310173,
-0.017248612,
0.0010488118,
-0.019600088,
-0.038986407,
-0.024770664,
-0.008671069,
-0.032252632,
-0.00091103,
0.0053943666,
-0.0049568047,
0.015164349,
0.0036875422,
-0.028645255,
0.0082301665,
-0.0051705753,
0.013293857,
-0.020054352,
0.009940331,
0.0031280646,
-0.00044591204,
-0.020775827,
-0.012505578,
-0.020094432,
0.008437257,
0.0328405,
0.0070544286,
-0.011870947,
0.0012809533,
-0.0019873981,
-0.007027707,
-0.015070825,
-0.020976236,
0.020521974,
-0.011182873,
0.017328776,
-0.017462382,
-0.0039781365,
-0.041364603,
0.012265086,
-0.012592422,
0.026774762,
-0.014162299,
-0.021764515,
-0.0131669305,
0.011363242,
-0.0021610868,
0.0098468065,
0.0056381985,
0.0020274802,
0.014589841,
-0.02609337,
-0.0064298175,
0.022192057,
0.005755104,
0.029366732,
-0.0055146124,
0.011369921,
0.008163364,
0.019560006,
-0.014763529,
0.0011690578,
-0.014309267,
0.046120998,
-0.012311848,
-0.01658058,
-0.011503528,
0.012251725,
0.010641766,
0.0073750843,
-0.0072815595,
-0.030756239,
-0.03944067,
0.007555453,
0.02002763,
-0.0012057995,
-0.01662066,
0.004272071,
-0.021564106,
-0.00014863734,
-0.031130338,
-0.018531235,
0.036581486,
-0.03781067,
-0.0042587104,
-0.0057050018,
0.014589841,
0.020388367,
0.0251314,
0.01052152,
-0.014095496,
0.029099518,
-0.008016396,
0.00566826,
0.004983526,
0.0032082284,
-0.008109921,
0.023848778,
-0.022192057,
-0.031611323,
-0.007862749,
-0.030114928,
-0.032760337,
-0.0074752895,
-0.015819022,
0.011470127,
0.0076890597,
-0.020174596,
0.0010847186,
0.011897668,
0.028003944,
-0.012712668,
-0.014242464,
-0.00748865,
-0.04109739,
0.018384269,
-0.0018487814,
0.028458206,
-0.026267057,
-0.015885824,
-0.01802353,
0.01377484,
-0.012893037,
0.0030879825,
0.0035272143,
0.015297956,
0.012518939,
0.011082668,
0.007181355,
-0.0064331577,
-0.028003944,
0.0023698471,
0.010989143,
0.0072815595,
-0.009165413,
-0.007669019,
-0.020147875,
0.010441355,
-0.0052674403,
-0.0059955963,
0.0067304326,
-0.023033777,
-0.05443133,
-0.009065208,
-0.02411599,
0.028110828,
0.007201396,
0.014723447,
-0.021964924,
-0.013527668,
-0.012338569,
-0.036715094,
0.01842435,
-0.0030261895,
0.015137628,
0.021791236,
-0.00992029,
-0.007669019,
-0.009853487,
-0.006055719,
0.0012976541,
-0.015685415,
0.00546117,
0.009506109,
0.03476444,
0.0024466708,
-0.016166398,
-0.022111893,
0.022151975,
0.0030228493,
-0.01759599,
0.020802548,
-0.017261973,
0.017074924,
-0.018651482,
-0.002045851,
0.016246563,
-0.00037013204,
0.026414026,
-0.012037954,
-0.008123281,
-0.0021443858,
0.00789615,
0.005107112,
0.011590373,
0.0003887117,
0.020000909,
-0.00566492,
-0.0077224616,
-0.006840658,
0.006219387,
-0.016032793,
0.022432549,
0.022205416,
-0.0035105133,
0.0071947156,
0.00606908,
-0.011182873,
-0.01557853,
-0.017996809,
-0.034497224,
-0.00023840427,
0.0014930537,
-0.026213614,
-0.004085022,
-0.016740907,
-0.0052841413,
-0.02792378,
-0.010908979,
-0.013681316,
-0.00017588056,
-0.03198542,
0.021777876,
-0.009833446,
0.010087298,
0.009579593,
0.008136642,
-0.0012283457,
0.017515825,
-0.008944962,
0.004796477,
-0.020709023,
0.0070677893,
0.0044825017,
-0.013828283,
-0.014229103,
-0.0015222802,
-0.02326091,
-0.011256356,
-0.004903362,
0.19260727,
-0.01842435,
-0.02388886,
0.009466028,
-0.0075754942,
0.009679798,
0.01819722,
0.0020057692,
-0.0069609038,
0.000349256,
0.0121648805,
0.010701889,
-0.0051906165,
-0.0067237522,
0.03078296,
-0.017555907,
-0.028832305,
-0.0210564,
-0.028324598,
-0.013607833,
-0.0036775216,
-0.01659394,
-0.0016149698,
0.0108822575,
0.017315416,
-0.0015464964,
-0.033107717,
0.0025051238,
0.019907383,
-0.0042219684,
-0.034951486,
-0.006312912,
0.0051705753,
-0.020548696,
-0.008236847,
0.0010454716,
-0.018745005,
-0.018090334,
-0.02490427,
-0.0043388745,
0.004405678,
0.016019432,
-0.025585664,
0.0087044705,
-0.008838077,
-0.011804143,
0.014563119,
-0.011784102,
-0.00020134932,
-0.006219387,
-0.038639028,
-0.0011348211,
0.019600088,
0.006232748,
-0.0033735665,
-0.022245498,
0.00005318169,
-0.003684202,
0.0060156374,
0.041418046,
-0.021403778,
0.0108822575,
-0.014242464,
0.054885592,
-0.024770664,
0.032920666,
-0.0142558245,
-0.00024111816,
0.02184468,
-0.02853837,
0.012338569,
-0.023394516,
-0.021310253,
0.015378119,
-0.024810746,
-0.01941304,
0.042887717,
0.043903127,
0.012438774,
0.02001427,
0.017141728,
0.00026992708,
-0.008637667,
0.010033856,
-0.0030128288,
-0.021016318,
0.009693159,
-0.0020692323,
-0.0148704145,
-0.024743943,
-0.0018738325,
-0.027977223,
-0.0028975932,
0.00057701353,
0.0075020106,
-0.008036437,
0.004622788,
0.014910497,
-0.013146889,
-0.0008367113,
-0.04251362,
0.07278888,
-0.012913078,
0.011556971,
-0.00044298937,
0.013801562,
0.0052106576,
0.019787138,
0.009973733,
0.007214756,
0.012799513,
-0.022686401,
0.011670536,
0.00021293551,
0.009452667,
0.025051238,
0.014790251,
-0.036340997,
0.012579061,
-0.0057150223,
-0.019947466,
-0.036875423,
0.005290821,
0.0012508918,
-0.0109357005,
0.0057384036,
-0.029072797,
-0.0042787516,
-0.010975782,
-0.02227222,
-0.017863203,
-0.0058553093,
-0.003807788,
0.00525742,
0.013788201,
-0.0003793175,
0.017903285,
-0.019960826,
-0.0042186286,
0.01576558,
0.00037555982,
0.020174596,
0.013634553,
0.0006864039,
-0.0007018522,
-0.029019354,
0.021336975,
-0.0026454106,
-0.030301977,
-0.008490699,
-0.03644788,
-0.011309799,
-0.021096483,
0.0026420706,
0.021711072,
-0.0099336505,
-0.01759599,
-0.0388528,
-0.008383814,
0.030622633,
-0.041124113,
0.009379183,
0.009379183,
-0.010842175,
-0.008463978,
0.0011707279,
-0.16780989,
0.0024433306,
0.017689513,
-0.021163285,
0.030328698,
0.017983448,
-0.001803689,
-0.018691564,
0.0023147343,
0.0076556583,
0.023367794,
0.0012934789,
-0.021002958,
0.0019539965,
0.0055179526,
0.024369843,
-0.012913078,
0.021964924,
0.01943976,
0.024516812,
0.020949515,
-0.022739843,
0.0126926275,
-0.01436271,
-0.0018254002,
0.029607223,
0.010314429,
-0.0033869273,
-0.01213816,
-0.020615498,
-0.012051315,
0.0019506564,
0.020521974,
-0.0034971528,
0.040589686,
-0.012505578,
-0.010013815,
-0.018477794,
-0.0053977068,
0.013868365,
0.009766643,
0.030916568,
0.0055580344,
-0.012492217,
-0.0063863955,
0.036528043,
0.0022111891,
-0.0066703097,
0.020749105,
0.02507796,
0.02428968,
-0.0026003185,
0.012238365,
0.019332875,
0.018504513,
0.033775747,
0.003381917,
0.022913532,
-0.012726028,
-0.0049568047,
-0.0023698471,
-0.0037710464,
0.042460177,
0.029714108,
-0.010401274,
-0.03155788,
-0.001964017,
0.008484019,
-0.035379026,
0.004004858,
-0.027055336,
-0.010287709,
-0.00053108623,
-0.030328698,
0.021336975,
-0.019907383,
0.0013385711,
0.018544596,
0.00728824,
-0.003256661,
-0.02247263,
0.0068172766,
-0.051545426,
-0.016006071,
-0.006008957,
0.02754968,
0.01658058,
0.014883775,
-0.014055414,
0.008617626,
0.0052841413,
-0.011764062,
0.018704925,
-0.009078569,
0.036287554,
0.037596896,
-0.011309799,
0.009459347,
-0.030756239,
-0.014603201,
0.02286009,
-0.01941304,
-0.0054979115,
0.024810746,
0.033027552,
0.015271234,
-0.010588323,
-0.0044591203,
0.03155788,
-0.012418734,
0.0003966446,
-0.007047748,
-0.0071011907,
0.0070076664,
-0.0008609275,
0.016607301,
0.0054678502,
-0.001539816,
-0.008884839,
-0.015097545,
0.07027707,
-0.008163364,
0.02530509,
0.011563651,
0.010427996,
-0.0071947156,
-0.1372407,
-0.03577985,
0.009379183,
0.019466482,
-0.015551808,
-0.0014663325,
-0.007448568,
0.03845198,
-0.029473616,
0.02732255,
-0.018063612,
-0.009913609,
0.015832381,
-0.0035038332,
-0.00749533,
-0.018103695,
0.008357093,
0.0015297956,
-0.023835417,
0.05061018,
-0.008597584,
0.016981399,
0.010140741,
-0.03099673,
0.0013485916,
-0.00023715172,
-0.02998132,
0.008363773,
0.005791846,
0.000031027,
-0.003483792,
-0.007635617,
0.016740907,
-0.0063229324,
-0.023140663,
0.005491231,
0.009960372,
-0.017101645,
0.052641,
0.00030395502,
-0.012238365,
0.012859635,
-0.0076823793,
0.021403778,
0.004068321,
-0.028378041,
-0.02573263,
0.02324755,
0.00025322626,
-0.012559021,
-0.0116371345,
-0.0017669473,
-0.010835495,
0.0012867986,
0.015137628,
-0.020415088,
0.03663493,
0.021176646,
-0.016219841,
-0.00033693915,
-0.002994458,
-0.0046027475,
-0.008397175,
0.00831033,
0.015819022,
-0.02749624,
-0.018758366,
-0.016874515,
0.017943367,
-0.02288681,
-0.012799513,
-0.0056415386,
-0.02104304,
-0.010875577,
-0.037783947,
0.0067571537,
-0.01337402,
-0.012879676,
0.011817504,
-0.028164271,
-0.011383282,
-0.02022804,
0.0131669305,
-0.0039146733,
0.014683366,
-0.009439306,
-0.014816972,
-0.0032115686,
0.011289758,
-0.0061358833,
-0.004412358,
0.051144607,
-0.004095042,
-0.010468077,
-0.02771001,
0.025238287,
0.012378652,
-0.016153038,
0.029740829,
0.008924921,
-0.008303651,
-0.025425335,
-0.051919524,
0.022579515,
-0.01759599,
0.008744552,
0.003864571,
-0.013140209,
0.019747056,
0.008637667,
0.0049868664,
0.017155087,
-0.0073617236,
0.0071947156,
-0.0070744697,
-0.032038864,
-0.026400665,
-0.009980413,
0.0263205,
0.0033067635,
0.005163895,
0.039360505,
0.02326091,
-0.0022980336,
0.01052152,
0.012732709,
-0.013427463,
0.0023080541,
-0.011389962,
0.02045517,
-0.010100659,
0.008637667,
-0.00048808163,
-0.026053287,
-0.008884839,
0.0057384036,
-0.025224926,
-0.004779776,
0.008777954,
0.02064222,
0.031237224,
0.04940772,
-0.016687464,
-0.018557956,
0.0031397552,
0.0019873981,
0.01337402,
0.00092856586,
-0.025251647,
-0.0038378497,
0.0007402641,
-0.024596974,
0.032306075,
0.015752219,
0.010942381,
-0.024409926,
-0.025786074,
-0.015859103,
0.0010863887,
-0.00009858706,
-0.025585664,
-0.010274348,
0.0034236691,
0.011877627,
0.015110906,
0.039627716,
-0.015444923,
-0.0014020343,
-0.026761401,
-0.021831319,
0.0017452362,
-0.036180668,
-0.013454185,
-0.008430577,
0.024677139,
-0.009432626,
-0.0072949203,
-0.0035539356,
-0.043475587,
-0.015485005,
-0.022953615,
0.034149848,
0.004712973,
-0.006376375,
-0.010835495,
0.0059154322,
0.042299848,
-0.017636072,
-0.012338569,
-0.0055780755,
-0.0038712514,
0.017475743,
-0.0021777875,
0.020682301,
0.013721398,
0.015044103,
-0.016433612,
0.03254657,
-0.000044387663,
0.0036775216,
-0.0021009638,
0.016500415,
0.015004021,
-0.008544142,
-0.0018487814,
0.0047530546,
-0.011049266,
0.044223785,
-0.036340997,
-0.048338868,
-0.013607833,
0.027082058,
0.013120168,
0.011256356,
0.0024032488,
0.0084238965,
-0.014910497,
0.034363616,
-0.00048682906,
-0.0034904724,
-0.0092322165,
0.029500337,
0.019012218,
-0.01132984,
0.012672586,
-0.0030863124,
0.032466404,
-0.00728824,
0.020054352,
-0.032760337,
0.026186895,
-0.013273816,
0.019720335,
0.00031522807,
-0.031718206,
-0.002511804,
-0.0063095717,
0.0059655346,
0.008337052,
0.018745005,
-0.01902558,
0.084920354,
0.016981399,
-0.017502464,
0.000019075474,
-0.0133606605,
0.024997795,
0.017489104,
0.014068775,
-0.002854171,
-0.0057985266,
0.0029360051,
-0.027603123,
0.016273284,
-0.031931978,
-0.031130338,
0.03300083,
-0.00566158,
0.021697711,
-0.005304182,
-0.0077825845,
0.018544596,
-0.006613527,
-0.0010162452,
0.025345173,
-0.03385591,
0.0132537745,
0.03222591,
0.013948529,
-0.0077491826,
-0.0028491607,
0.003911333,
-0.0081767235,
-0.03505837,
0.010541561,
0.014108857,
-0.016273284,
-0.002326425,
-0.03620739,
0.030916568,
0.018317465,
-0.0029443554,
-0.004839899,
-0.008637667,
-0.01213816,
0.0108822575,
-0.021497302,
-0.019827219,
-0.029687386,
0.0025752673
] |
The gut mucosal epithelium separates the host from the microbiota, but enteropathogens such as Salmonella Typhimurium (S.Tm) can invade and breach this barrier. Defenses against such acute insults remain incompletely understood. Using a murine model of Salmonella enterocolitis, we analyzed mechanisms limiting pathogen loads in the epithelium during early infection. Although the epithelium-invading S.Tm replicate initially, this intraepithelial replicative niche is restricted by expulsion of infected enterocytes into the lumen. This mechanism is compromised if inflammasome components (NAIP1- | [
0.003104719,
0.011337233,
0.0008199964,
-0.00568197,
-0.03023262,
0.016905697,
-0.009334188,
-0.0014914336,
-0.00097231125,
-0.0022534253,
0.03159469,
-0.0049809045,
0.0050877333,
0.007591539,
0.0023569157,
0.0014113119,
0.03170152,
0.011911439,
-0.03538712,
0.017720269,
-0.029698474,
0.014261678,
0.012799455,
-0.021205565,
-0.006109286,
0.017226184,
0.016131187,
-0.039873943,
-0.031354327,
-0.010889886,
-0.00004715501,
0.001113359,
-0.023088427,
0.0064464654,
-0.0030513047,
-0.00013854392,
0.020511176,
-0.010983361,
0.036241755,
-0.005054349,
0.017426489,
0.015717223,
-0.0044267285,
0.005144486,
-0.010896563,
-0.008759982,
-0.007304436,
0.013700825,
-0.023382207,
-0.0056452476,
0.022060199,
-0.024543973,
-0.028843842,
0.0084728785,
-0.034585904,
0.011811286,
0.013901129,
-0.020230751,
0.0018978848,
-0.013901129,
0.0060892557,
0.018521486,
-0.018254414,
-0.0034919744,
-0.0027608632,
0.010963331,
-0.0074847103,
-0.0058856127,
-0.0056953235,
0.022861416,
0.019215874,
0.04572283,
-0.00396269,
-0.016945757,
0.027374944,
-0.033197127,
-0.016905697,
0.0029344603,
-0.007912027,
0.01589082,
0.009220682,
-0.027174639,
-0.02897738,
0.022634404,
0.025171595,
-0.012592474,
0.016732099,
0.005328099,
0.005418236,
-0.001641662,
0.017626792,
0.024450498,
0.014555458,
0.026974333,
-0.013193388,
0.02555885,
-0.022861416,
0.042197473,
0.024650803,
-0.036108218,
-0.015183078,
-0.0035754347,
-0.0059824265,
-0.02111209,
-0.040247843,
-0.0043833293,
0.01123708,
-0.016131187,
0.034212,
-0.021726357,
-0.024063243,
0.008886841,
-0.022514222,
-0.03843175,
0.015637102,
0.017787036,
0.020137275,
-0.006780306,
-0.018040756,
-0.021312395,
0.00930748,
0.008866811,
-0.0011467431,
-0.015396737,
0.029351281,
0.004219747,
-0.023408914,
-0.005061026,
-0.009668029,
-0.01574393,
0.00036388644,
0.015663808,
0.017533317,
0.008139038,
-0.014181556,
0.007271052,
-0.025371898,
-0.010215527,
-0.0116577195,
-0.002318524,
0.022460807,
0.019109046,
0.0039526746,
0.005822183,
0.010636167,
0.022086905,
0.017493257,
0.020070506,
0.0116577195,
0.022086905,
0.021485992,
-0.03391822,
-0.02398312,
-0.023262026,
0.0056218784,
0.043719787,
-0.0013453783,
0.048446972,
-0.01849478,
-0.012739364,
-0.0126392115,
-0.022834709,
0.02453062,
0.019068984,
0.005331437,
0.017199477,
0.011604305,
0.045188688,
0.005788799,
-0.022821356,
0.0019346073,
0.018000694,
-0.015970942,
0.019362764,
-0.009534492,
0.018882034,
-0.012752717,
0.013320247,
-0.0062428224,
-0.055123787,
-0.018401302,
0.01956307,
0.035360415,
0.006843736,
-0.017426489,
-0.012251956,
0.030179206,
0.017733622,
-0.011404001,
-0.020123921,
-0.0054916805,
0.018334536,
-0.012111743,
-0.0035153434,
-0.6341372,
-0.03549395,
0.017720269,
-0.009447694,
0.0010332372,
0.0070240097,
0.005404882,
-0.028309697,
-0.02092514,
0.0059490427,
-0.023675987,
-0.008793366,
0.010836472,
-0.0068637663,
-0.003471944,
-0.021232273,
-0.011510829,
-0.010936623,
0.011831317,
-0.001941284,
-0.006780306,
-0.015650455,
-0.0018277782,
0.031728227,
-0.008719921,
0.017813744,
0.030766765,
-0.0079721175,
-0.010128729,
0.024837753,
-0.045963198,
0.01842801,
-0.010081992,
-0.004159656,
0.049595386,
-0.00228514,
-0.01897551,
0.02857677,
0.0115642445,
0.040167723,
-0.0020047138,
-0.019830141,
-0.005431589,
0.011791256,
0.006249499,
0.019429533,
0.02019069,
0.017453196,
0.0061560236,
-0.0072977594,
0.005144486,
0.022487514,
-0.019442886,
0.014996127,
0.037897605,
0.003128088,
0.024851106,
-0.026760677,
0.0013620703,
0.014862591,
-0.00036388644,
0.006252838,
-0.018628314,
-0.014929359,
-0.015757285,
0.0016391582,
-0.02111209,
-0.0033317308,
0.014502043,
-0.00033196292,
0.012465615,
0.030259328,
-0.016251368,
0.015717223,
0.0121384505,
0.058168415,
-0.023956414,
0.015677163,
-0.004904121,
0.004910798,
-0.0019746681,
0.007564832,
-0.0040394734,
0.018748498,
0.02599952,
-0.006696846,
-0.010355741,
0.024290254,
-0.014929359,
-0.0038057847,
-0.0024019843,
0.024757631,
-0.0019346073,
-0.047458805,
-0.016812222,
0.009514462,
-0.016745454,
-0.00687712,
-0.00027437537,
-0.018948803,
0.0029211068,
-0.009594584,
0.014916006,
0.01511631,
0.035947975,
0.021232273,
-0.018588254,
0.006266191,
0.031060545,
-0.033117004,
-0.0033584381,
0.002260102,
0.00076616456,
-0.02306172,
-0.0144352745,
-0.022514222,
0.038752235,
0.017613439,
-0.015797345,
-0.03479956,
0.017453196,
-0.012592474,
0.0017843789,
-0.010135406,
0.014515397,
0.011116898,
0.014742409,
-0.013420399,
-0.015490212,
-0.0013929507,
0.0009814919,
-0.009868333,
0.039099433,
-0.012004914,
0.018401302,
0.01861496,
0.025759153,
-0.000691885,
-0.010248912,
-0.041609913,
-0.011724488,
-0.026213177,
0.020738188,
0.0026707263,
-0.02945811,
-0.020845018,
0.012425553,
-0.007818551,
0.017132709,
-0.028256282,
0.0037156479,
-0.0059423656,
-0.005061026,
-0.010302327,
0.020204043,
-0.006483188,
-0.000039278453,
-0.0218866,
-0.00884678,
-0.010135406,
-0.008512939,
0.027161285,
-0.00035700097,
0.0023719387,
-0.0065366025,
-0.008032209,
-0.004940843,
0.0025338514,
0.009060439,
-0.035226878,
0.0029661753,
-0.0095612,
-0.01555698,
0.009173945,
0.0062895603,
0.0009255735,
-0.0022384024,
0.010949978,
-0.018014047,
0.0038959219,
0.008833427,
-0.034746148,
0.0070640706,
0.009007024,
0.030713351,
0.0033968298,
0.0185749,
-0.0070774243,
0.024330316,
0.044707958,
0.027281469,
-0.0013069867,
-0.020123921,
0.016838929,
-0.0036789253,
-0.03950004,
0.018334536,
0.033464197,
0.0074112653,
0.0176535,
-0.011537537,
-0.039099433,
0.0016157894,
-0.04185028,
0.022046845,
-0.02258099,
-0.007765136,
-0.014835884,
0.03479956,
0.0064498037,
0.0010699597,
-0.0034418984,
-0.01285287,
-0.009507786,
0.0062428224,
0.019442886,
0.0066668,
-0.012131774,
-0.015583687,
0.0011550891,
-0.02354245,
0.0046136794,
0.0016917381,
-0.0073578507,
-0.023342147,
0.02927116,
0.013280186,
0.011203696,
-0.030579815,
-0.025038058,
0.015984297,
0.015917528,
0.022207089,
-0.0034919744,
0.032636274,
0.017453196,
-0.00031652278,
0.014582165,
0.009861656,
0.016264722,
-0.0039126137,
0.009941778,
-0.011958176,
-0.0068971505,
0.017493257,
-0.0021349117,
0.0019145769,
0.006296237,
-0.006239484,
-0.004496835,
0.017319659,
0.0141014345,
-0.032636274,
-0.010489277,
-0.022367332,
-0.015423444,
0.0029678445,
0.0022717866,
0.038164675,
0.0076983683,
-0.014502043,
-0.019509654,
0.0036255107,
-0.027228054,
0.024143364,
0.0091005,
-0.0074312957,
-0.02740165,
-0.0084728785,
-0.004887429,
-0.020804957,
0.0074847103,
0.014328446,
-0.0083794035,
-0.01478247,
0.002587266,
0.013834362,
0.014648933,
-0.010636167,
0.011651043,
-0.025024705,
-0.032689687,
0.031007132,
0.025959458,
-0.010963331,
0.013073205,
-0.032743104,
-0.015490212,
-0.007678338,
-0.0060625486,
0.023128489,
0.034692734,
0.010823118,
0.0064464654,
-0.021940015,
0.0114907995,
0.01633149,
-0.024997996,
0.016051065,
0.023235317,
0.0026006196,
-0.008179099,
-0.026573725,
-0.0073712044,
0.01184467,
-0.0014321769,
-0.014555458,
-0.019469595,
-0.022821356,
-0.019442886,
-0.010722966,
-0.0044000214,
-0.025024705,
-0.023115136,
0.0006914677,
0.006539941,
-0.01861496,
-0.0015982627,
0.035413828,
-0.0055117114,
-0.011036776,
-0.037924312,
-0.027321529,
-0.010736319,
0.027909089,
0.017319659,
-0.018561548,
0.033571027,
0.02788238,
-0.014461982,
0.013587319,
-0.047939535,
0.02740165,
-0.030125791,
-0.01629143,
0.014595519,
0.0054482813,
0.007451326,
0.036134925,
0.014809176,
0.000011873516,
-0.022634404,
-0.01769356,
0.01754667,
0.015329968,
-0.014168202,
0.013981251,
0.007851935,
0.010035253,
-0.014421921,
0.00095979223,
0.02155276,
0.0176535,
-0.01662527,
0.0004360795,
-0.010188821,
0.007244345,
0.0050076116,
0.004333253,
-0.009688059,
-0.004346607,
-0.016424965,
-0.0069372114,
0.008032209,
0.02218038,
0.015276554,
0.0072977594,
0.000867986,
-0.014849237,
-0.0109900385,
0.008492909,
0.005658601,
-0.009928425,
-0.042891864,
0.01750661,
0.0020514515,
-0.00324994,
-0.02467751,
0.026560372,
0.01739978,
0.010235558,
0.0014321769,
-0.017853804,
-0.01138397,
-0.019656545,
-0.031247497,
0.0100219,
-0.0011876385,
-0.018601608,
0.0001727626,
-0.005274684,
-0.0041463026,
-0.03111396,
-0.0003628432,
-0.005772107,
-0.027027749,
-0.032609567,
-0.006256176,
-0.0059657344,
0.019362764,
0.018855326,
-0.012552413,
-0.018868681,
0.022407392,
0.01721283,
-0.013580643,
0.0076583074,
-0.025078118,
0.022500869,
-0.006309591,
0.0007269383,
-0.0109165935,
-0.026506957,
-0.00075823587,
0.001735972,
0.005247977,
0.0026473573,
0.014301739,
-0.011631013,
0.023916353,
0.011444062,
0.014114788,
-0.010175467,
-0.01169778,
-0.008005502,
-0.0375237,
-0.0062194536,
0.004436744,
-0.0032900008,
-0.031167375,
-0.010562722,
0.003306693,
-0.00028397332,
-0.0047438773,
0.028042626,
0.0052913763,
-0.0106762275,
-0.009187298,
0.00044359092,
0.015009481,
-0.0007077424,
0.022928184,
0.016451674,
0.012632535,
-0.029725183,
0.010429186,
0.005288038,
-0.009153914,
-0.011437384,
0.0017693561,
0.011450739,
-0.016238015,
-0.030686643,
-0.029832011,
0.0068103517,
0.01585076,
0.011904762,
-0.04409369,
-0.015663808,
-0.004994258,
-0.005772107,
0.019068984,
-0.015757285,
-0.038752235,
0.0015398406,
-0.010469247,
-0.010389125,
-0.014729055,
0.005231285,
-0.035173465,
0.008693214,
0.027321529,
0.0047872765,
0.01614454,
0.02228721,
0.010689582,
-0.0200438,
0.013266833,
-0.01864167,
-0.04019443,
-0.01077638,
-0.0038525225,
0.044601128,
0.028443234,
0.03722992,
-0.007531448,
0.044387467,
0.013473813,
0.005551772,
0.0016867305,
-0.013660764,
0.010829794,
-0.005688647,
-0.0038024464,
0.004336592,
-0.0045335577,
0.0009047085,
0.011183666,
0.000031010677,
0.0036088186,
-0.008739951,
0.009080469,
-0.024851106,
-0.02408995,
-0.019068984,
0.011163635,
-0.006459819,
0.00067561027,
-0.03626846,
0.0044768048,
0.022247149,
0.005174532,
0.014862591,
0.018815266,
0.024156718,
-0.008025533,
0.02828299,
-0.015196432,
0.0064297733,
0.009107176,
-0.012038298,
0.001498945,
-0.027334882,
0.012946345,
-0.0068637663,
0.010636167,
-0.009981839,
-0.008105654,
-0.008025533,
0.0029544907,
0.0065866783,
-0.038031142,
0.005845552,
0.0000521887,
-0.040648453,
-0.004797292,
-0.011203696,
-0.0452421,
-0.00050618604,
-0.016077772,
-0.009567876,
0.011811286,
-0.016999172,
-0.0052079163,
-0.0005817175,
0.013420399,
0.011417354,
-0.02419678,
0.024357023,
0.012278664,
-0.010829794,
-0.028603477,
0.012425553,
-0.016465027,
0.0031147343,
0.036348585,
0.016518442,
0.016932404,
-0.013901129,
-0.0059657344,
0.010970008,
0.017239537,
-0.033784688,
0.043372594,
0.036615655,
0.015356676,
-0.02063136,
-0.009153914,
-0.009641321,
0.018107524,
-0.016705392,
0.00987501,
-0.013714178,
-0.006403066,
0.00039560132,
0.013580643,
0.019242583,
0.031915177,
-0.013834362,
-0.0007452995,
-0.0060325027,
-0.03669578,
-0.018374596,
0.0026490265,
0.017479902,
0.011610982,
0.0024103303,
0.017893866,
0.0053815134,
0.021512698,
0.012205219,
-0.009627968,
-0.0023903,
0.03747029,
0.0068337205,
-0.013727533,
0.0041563176,
0.0111569585,
0.01861496,
-0.03520017,
0.008112331,
-0.0076850145,
-0.020297518,
-0.013173357,
0.025692387,
0.011437384,
-0.011744519,
0.0043766527,
-0.02371605,
-0.0118980855,
-0.031915177,
-0.0042364392,
0.011003392,
-0.021472638,
0.0014588842,
0.0040261196,
-0.013260155,
0.017479902,
0.008359373,
0.0004390006,
-0.02740165,
0.009407633,
-0.025986165,
0.0051077637,
0.009020378,
0.012625858,
-0.006539941,
-0.011791256,
-0.007531448,
-0.009661352,
0.015810698,
-0.03266298,
-0.015276554,
-0.012906284,
-0.011744519,
0.014275031,
-0.0019679912,
-0.03365115,
0.013053174,
-0.009848303,
0.021325748,
-0.011504153,
0.0040428117,
0.029404694,
-0.030873595,
-0.0011809617,
0.010515984,
0.00985498,
-0.0050877333,
0.008986994,
-0.011764549,
0.0025906044,
-0.016692039,
0.0030329435,
-0.0075381245,
-0.012906284,
0.00011893077,
-0.017079294,
0.0031981946,
0.014902652,
-0.009968486,
-0.009113853,
-0.013493844,
-0.027962502,
-0.00928745,
-0.010996715,
-0.0116577195,
0.020885078,
0.00097147666,
-0.0040728576,
0.008392757,
-0.0037056326,
-0.008492909,
-0.012739364,
-0.020284165,
0.040354673,
0.0002426605,
-0.0042130705,
0.0009814919,
0.0071108085,
-0.02769543,
-0.020390995,
-0.0021866572,
0.002144927,
0.0056452476,
0.0073979115,
-0.009133884,
-0.0030930347,
-0.022888124,
0.018000694,
-0.012332078,
0.0062261303,
0.011797933,
-0.03626846,
0.029938841,
0.002750848,
-0.01643832,
-0.036001388,
0.032556154,
0.015196432,
0.013914484,
0.022701172,
-0.0143418,
0.005558449,
0.0002178311,
0.011317202,
0.022808002,
0.00899367,
0.01897551,
0.008012178,
-0.008025533,
0.010362417,
-0.010616137,
-0.021445932,
0.00081123307,
0.008739951,
0.015129664,
0.010489277,
0.0077250754,
-0.01570387,
0.0027308175,
-0.016344843,
0.035841145,
0.0323692,
0.0026740646,
0.008372727,
-0.0016258046,
-0.022741234,
-0.015516919,
0.008285928,
-0.02383623,
-0.0038224768,
-0.008626445,
-0.016384905,
-0.04270491,
-0.010035253,
-0.007691691,
-0.009494431,
-0.009794888,
0.002652365,
-0.016157893,
-0.011464092,
0.004840691,
0.013440429,
0.016371552,
-0.0076115695,
0.0023302087,
-0.016812222,
0.004176348,
0.007591539,
-0.0031664798,
-0.0062862216,
0.0200438,
-0.023448976,
-0.010175467,
-0.00025100654,
-0.0006422262,
-0.00017651831,
-0.00987501,
-0.0053781746,
0.1802206,
-0.023729403,
0.0077851666,
0.00794541,
0.00031130653,
-0.010262265,
-0.007845258,
0.008666506,
-0.014021313,
0.011884731,
0.009227359,
-0.0014480343,
0.020230751,
0.010275619,
0.029511524,
-0.016131187,
-0.029912133,
-0.019042278,
-0.027174639,
-0.019322705,
0.021632882,
-0.017199477,
0.014141495,
0.009901717,
0.036028095,
0.0029127607,
-0.0272147,
0.006640093,
0.0014054696,
0.0032950083,
-0.016678685,
0.012165158,
0.02570574,
0.014181556,
0.0067168763,
0.0057988144,
-0.02262105,
-0.0049775657,
0.014648933,
0.0029912132,
0.014368507,
0.006670139,
-0.003635526,
0.008332666,
-0.022674466,
0.0030279357,
-0.012018268,
-0.009781535,
0.00021720515,
0.008606415,
-0.032716397,
0.0071508694,
0.019482948,
0.0011292164,
-0.019977031,
-0.021966722,
-0.008719921,
0.008579708,
0.010355741,
0.030099085,
-0.017519964,
0.021913309,
-0.028202869,
0.037897605,
-0.016238015,
0.047245145,
-0.023662634,
0.0032232327,
-0.005688647,
-0.032556154,
0.0020347596,
-0.03188847,
-0.040327966,
-0.009614614,
-0.018655023,
0.008673184,
0.017146062,
0.0007553148,
0.011631013,
0.019776728,
-0.008132361,
0.00280927,
-0.038271505,
0.010409155,
0.010622813,
-0.034986515,
0.029725183,
0.0035120049,
-0.0075715086,
-0.0019012232,
-0.0012744372,
-0.0019863525,
-0.00306132,
-0.006443127,
0.021980077,
-0.02975189,
0.0161846,
-0.0050243037,
0.005675293,
0.00005795267,
-0.037123095,
0.064845234,
-0.0012761063,
-0.011664396,
0.00073904,
0.024851106,
-0.0052279467,
0.009007024,
0.007157546,
-0.02262105,
-0.002528844,
-0.0065599713,
0.002203349,
-0.0072910823,
0.007157546,
0.018695083,
0.022220442,
-0.01574393,
0.031835057,
-0.0075715086,
-0.018708438,
0.010215527,
0.021566113,
0.009374249,
-0.029431403,
-0.009754827,
-0.026453543,
0.030179206,
-0.008252544,
-0.032609567,
-0.0065366025,
-0.021285689,
-0.0066067087,
0.018922094,
0.0043032076,
-0.00025810066,
0.021472638,
-0.016197953,
-0.013380338,
0.020791603,
-0.008526294,
0.008165745,
0.002859346,
0.0008099812,
0.0023151857,
-0.016732099,
0.023075074,
-0.0075781853,
-0.023368854,
-0.020564592,
-0.012746041,
-0.026173117,
-0.017813744,
-0.01209839,
0.007524771,
-0.04732527,
-0.020564592,
-0.028790427,
-0.007391235,
0.0067335684,
-0.002694095,
0.0153433215,
-0.0017476564,
-0.01868173,
0.0016132855,
0.008152392,
-0.16740112,
0.015730577,
-0.0016875651,
-0.003413522,
0.03805785,
0.009053762,
-0.0042765,
0.026199823,
-0.018908741,
0.02463745,
0.04612344,
0.014448629,
-0.03170152,
-0.0100219,
-0.0016950765,
-0.003029605,
-0.007391235,
0.000097804914,
0.011711135,
0.017626792,
0.039339796,
-0.025772508,
-0.0033534307,
0.00078410853,
-0.008245867,
0.015944235,
0.011891408,
0.03560078,
0.0008058082,
-0.020938493,
0.00020395585,
0.00089218945,
0.04078199,
0.0109433,
0.026547018,
-0.016611917,
0.007564832,
-0.010455893,
-0.0014038004,
0.021619529,
0.029377988,
0.0056953235,
0.006035841,
0.0014213271,
-0.018201,
-0.0012961368,
-0.015917528,
0.0031965254,
0.02916433,
-0.0124722915,
0.008813396,
-0.014208263,
-0.012372139,
0.027374944,
0.008312635,
0.021085383,
0.0017893865,
-0.002635673,
0.007811874,
-0.003652218,
-0.011470769,
-0.005788799,
0.03335737,
0.00838608,
-0.0019279305,
-0.04748551,
-0.0032699704,
0.005354806,
-0.009581231,
0.0046737706,
-0.014315092,
-0.01000187,
0.008893518,
-0.03207542,
0.022233795,
0.02033758,
0.0017343028,
-0.0038425073,
-0.029404694,
-0.0037724008,
-0.026440188,
-0.000034557735,
-0.045001738,
-0.014688994,
-0.018748498,
0.010202174,
-0.017333012,
0.008359373,
-0.01348049,
0.00897364,
0.0115842745,
-0.022968246,
0.0066668,
-0.029965548,
0.048126485,
0.0371498,
0.011190343,
0.007678338,
-0.007344497,
0.002612304,
0.010041931,
-0.03471944,
-0.017279599,
0.038672116,
0.022447454,
-0.0045602648,
-0.012919638,
-0.0046136794,
0.055818178,
-0.022220442,
-0.022046845,
-0.030286035,
0.0077250754,
0.007271052,
-0.012458937,
0.017146062,
0.011150282,
-0.008686537,
0.009200651,
-0.034479074,
0.051625136,
-0.023809524,
0.018695083,
0.027775552,
0.0007498898,
-0.028630184,
-0.14186898,
-0.040514916,
0.008539647,
-0.0042731618,
-0.012405523,
0.012338755,
-0.011924792,
0.009300804,
-0.0013403707,
0.014007959,
-0.03589456,
-0.015864113,
-0.0024286916,
-0.031915177,
0.018922094,
0.013914484,
0.029217744,
-0.0044300673,
-0.013874423,
0.016264722,
-0.0013261825,
-0.01677216,
0.017933926,
-0.0020431054,
0.0024186764,
-0.016318137,
-0.028256282,
0.02662714,
0.0031230804,
0.020310873,
0.02067142,
-0.00171928,
0.014715701,
-0.017319659,
0.021606175,
0.0017426488,
0.017920572,
0.0037356783,
0.009200651,
-0.01077638,
-0.020871725,
0.004420052,
0.02924445,
0.008873488,
-0.010769703,
-0.020511176,
-0.025906043,
0.014114788,
0.044253934,
-0.0126392115,
-0.016558502,
-0.014074727,
-0.04000748,
-0.013533905,
0.026506957,
-0.0012694296,
-0.0064631575,
0.020591298,
0.019509654,
0.009554523,
-0.0009380926,
0.007905349,
-0.008653153,
-0.001019049,
0.031648107,
-0.017720269,
-0.030766765,
-0.016545149,
0.016384905,
-0.008145715,
0.020604653,
-0.011644366,
-0.004036135,
0.022901477,
-0.005905643,
-0.011043453,
-0.00046028296,
-0.016251368,
-0.019696606,
-0.011711135,
0.013687472,
-0.020284165,
0.0077317525,
0.007164223,
0.03314371,
0.010903239,
-0.0031631412,
0.012886254,
0.007164223,
0.008052239,
-0.0027241406,
0.042651497,
0.025585556,
-0.012004914,
-0.0021799803,
0.02750848,
-0.013467137,
-0.017479902,
0.03549395,
0.0060625486,
-0.008125684,
0.0025388591,
-0.04516198,
-0.00028293006,
-0.0122319255,
0.008359373,
0.01285287,
0.0008588054,
0.0076249233,
-0.021192212,
0.020097215,
0.047111608,
-0.021606175,
0.035440538,
-0.014154849,
0.005298053,
-0.03423871,
-0.011437384,
0.010115376,
0.018294474,
0.015677163,
0.0356809,
0.0005537584,
-0.0101020215,
-0.018014047,
0.015102956,
-0.023742756,
0.02618647,
0.006019149,
0.019215874,
-0.019469595,
-0.014301739,
0.024704218,
-0.022514222,
-0.017933926,
0.008119008,
-0.002824293,
-0.0052780225,
-0.004773923,
0.010829794,
0.025144886,
0.030980423,
-0.011771225,
-0.036722485,
0.012225249,
-0.015650455,
0.014208263,
-0.0021415886,
-0.028870549,
0.0068904734,
-0.022928184,
-0.016131187,
0.039580163,
0.008866811,
0.003306693,
-0.004643725,
0.0039994125,
-0.0019112384,
0.0068337205,
0.0038959219,
-0.0015523596,
-0.027121224,
0.032609567,
0.025331838,
0.024330316,
0.022634404,
0.012038298,
-0.011270464,
-0.02677403,
-0.0153433215,
-0.007985471,
-0.029912133,
-0.005174532,
-0.015236493,
0.0014263347,
0.004623695,
0.010075315,
0.0077918437,
-0.014515397,
-0.0042731618,
-0.016611917,
0.030392865,
0.0013428745,
-0.008926902,
-0.017119355,
0.011717811,
0.031915177,
0.008412788,
-0.0010916593,
0.0044300673,
-0.0029761905,
-0.0016466696,
-0.02228721,
0.01153086,
0.00869989,
0.004593649,
-0.004840691,
0.014648933,
0.010682905,
0.017573379,
0.024944583,
0.007958764,
-0.00015283648,
-0.0007202615,
0.0013412053,
-0.005845552,
-0.010869855,
0.028790427,
-0.031674813,
-0.032823224,
-0.012819486,
0.0138610685,
-0.009207329,
0.016211309,
0.0106762275,
-0.0046203565,
-0.0305264,
0.012492321,
-0.0011575929,
0.00007751365,
-0.00029419718,
0.01897551,
0.005478327,
0.023635926,
-0.016091125,
-0.009407633,
0.0070707477,
-0.010475923,
0.021392517,
-0.013180033,
0.022607697,
0.023529097,
0.00031193247,
0.016197953,
-0.03343749,
-0.017106,
-0.010349064,
0.0012335416,
0.02342227,
0.02453062,
-0.017560024,
0.06837059,
-0.0013954544,
-0.015970942,
0.02081831,
-0.010716288,
0.015677163,
0.008272574,
0.020564592,
-0.002210026,
-0.023435622,
0.016104478,
-0.004543573,
0.014355153,
-0.026974333,
-0.018160937,
0.024450498,
-0.01930935,
-0.012191865,
-0.0125457365,
-0.012432231,
0.016985819,
-0.005101087,
0.0125457365,
0.015223139,
-0.042838447,
0.002276794,
0.01658521,
-0.0037123093,
0.02356916,
-0.025104826,
0.0019079,
-0.0042731618,
-0.029725183,
-0.030499693,
-0.004420052,
0.013273509,
-0.013093235,
-0.02107203,
0.022848062,
0.009441017,
0.0028376465,
0.015957588,
-0.02383623,
-0.016785514,
-0.00404615,
-0.009254066,
-0.031220788,
0.0020981892,
-0.0126392115
] |
Many of the factors required for chromosomal DNA replication have been identified in unicellular eukaryotes. However, DNA replication is poorly understood in multicellular organisms. Here, we report the identification of GEMC1 (geminin coiled-coil containing protein 1), a novel vertebrate protein required for chromosomal DNA replication. GEMC1 is highly conserved in vertebrates and is preferentially expressed in proliferating cells. Using Xenopus laevis egg extract we show that Xenopus GEMC1 (xGEMC1) binds to the checkpoint and replication factor TopBP1, which promotes binding | [
-0.010670792,
-0.007638396,
-0.009556437,
-0.03673994,
-0.027055185,
0.020355549,
-0.012149845,
0.0013760594,
-0.00064286456,
-0.009806323,
0.0245023,
0.016276335,
0.024839982,
-0.004021808,
-0.014520382,
0.0053185117,
0.027122723,
-0.011076012,
-0.0061863577,
0.023867454,
-0.00981983,
0.011582537,
-0.010008933,
-0.03973857,
0.008293502,
-0.0030712294,
0.0039745322,
-0.02885166,
-0.016789613,
-0.01070456,
-0.0055481363,
-0.018329449,
-0.018653626,
-0.025380276,
-0.025393784,
-0.0008931723,
0.016749091,
-0.016154768,
0.011508247,
-0.009286291,
0.019936822,
0.018342957,
0.00731422,
0.013507332,
-0.00812466,
0.02581251,
-0.0049234224,
-0.003839459,
-0.010198035,
0.007820745,
0.010819373,
0.0017491995,
-0.023570294,
0.0025478203,
-0.027933162,
-0.011062505,
0.019099368,
0.007955818,
0.005031481,
-0.019896299,
-0.013939566,
-0.0046769134,
-0.016208798,
0.0015381475,
-0.021706281,
0.008408314,
0.00011249074,
-0.02474543,
0.008489358,
-0.0027166621,
0.029067777,
0.015722534,
0.0011565653,
-0.010461428,
0.014520382,
-0.030148365,
-0.033930417,
0.0023891092,
0.0006470856,
0.0070575806,
0.006709767,
-0.007726194,
0.004116359,
0.0055109914,
0.000839143,
-0.0015803578,
-0.015709028,
-0.0052611055,
0.009279537,
-0.000316156,
0.025218189,
0.03603756,
0.04470927,
0.015249778,
-0.010008933,
0.0040792143,
0.012568573,
0.026960634,
-0.01720834,
-0.028824646,
-0.018099824,
0.004791726,
0.005902704,
-0.012872487,
-0.009752293,
-0.0069225077,
0.026177209,
-0.0083813,
-0.00067410024,
0.0026119803,
-0.015195748,
0.025907062,
-0.01346681,
-0.032120436,
0.00974554,
-0.036820985,
0.029905232,
-0.0066219694,
-0.012433499,
0.016735584,
-0.0003737732,
0.025042593,
0.0056122965,
-0.032228492,
0.0355513,
0.0037685456,
-0.022043966,
0.008975622,
0.005399556,
0.011987757,
0.018707654,
0.01313588,
0.010420906,
0.025366768,
-0.03719919,
-0.0015651621,
-0.00029209605,
-0.0028855037,
-0.007233176,
-0.031418055,
0.013460056,
0.034767874,
-0.009070173,
-0.00035076853,
0.012021525,
0.013757218,
-0.0037314005,
-0.002858489,
0.008070631,
0.028581513,
0.0008070631,
0.00057828263,
0.023826933,
0.0058925734,
0.011629812,
0.026798546,
-0.006895493,
0.031120893,
-0.012230889,
-0.017546024,
-0.0061120675,
0.005615673,
0.013790986,
-0.024731925,
0.0025224942,
0.0584057,
0.0045992467,
0.0072669443,
0.016424915,
-0.013237185,
-0.017437965,
0.017870199,
-0.054785736,
0.02080129,
-0.046816412,
0.01974772,
-0.00493693,
0.017140804,
-0.024515808,
-0.009732032,
-0.0021611731,
0.012926516,
0.0076721646,
-0.0094213635,
-0.022638287,
0.0061863577,
0.0016884165,
-0.0111097805,
-0.0027757566,
-0.011542015,
-0.016843643,
0.0023384567,
0.01949108,
0.009239015,
-0.6219856,
-0.0026727633,
0.005909458,
-0.025164159,
0.0013802805,
0.021098452,
0.011636566,
-0.0012663123,
-0.015682012,
0.0050787567,
-0.022097996,
0.006128952,
0.0020615566,
-0.026244745,
-0.011758132,
-0.055244986,
-0.0044439123,
-0.012075555,
0.01630335,
0.015263285,
-0.01999085,
-0.021476658,
-0.0053421496,
0.008887825,
-0.0018555697,
0.005514368,
0.029959261,
-0.023516264,
0.013872029,
0.026096165,
-0.028203309,
0.031255964,
-0.014885079,
-0.00213247,
0.041170347,
-0.009590206,
-0.007361496,
0.0028027713,
0.01593865,
0.029770158,
-0.014250235,
0.01543888,
0.002144289,
0.008556895,
-0.020787783,
0.016289841,
0.021125467,
0.016681554,
-0.016870657,
-0.010522211,
0.0006466635,
0.0189778,
-0.013818,
-0.015830593,
-0.0073750033,
0.030553585,
0.02592057,
-0.026947126,
0.005109148,
0.014412323,
-0.013169648,
0.01670857,
-0.023556786,
-0.010799112,
-0.012345701,
0.01705976,
-0.030634629,
-0.003981286,
0.00751683,
-0.014047625,
0.011244854,
0.013351997,
-0.0030104464,
0.011899959,
-0.0010147383,
0.041899744,
-0.019977344,
0.020936364,
0.0028888807,
0.014817542,
-0.008030109,
-0.013453302,
-0.007638396,
0.004609377,
0.02328664,
-0.0079355575,
-0.026744517,
0.018424,
-0.0020750638,
-0.010610009,
0.01447986,
0.0026018498,
0.0013363817,
-0.0239485,
-0.022408662,
0.01670857,
0.007483062,
0.012649616,
0.016681554,
-0.045789853,
0.005862182,
-0.029581057,
-0.0014309329,
-0.014034118,
-0.0012553376,
-0.008502865,
-0.020490622,
0.0057237316,
0.024772447,
-0.00582166,
-0.0016875722,
0.010299341,
-0.00022962464,
-0.008718982,
-0.01002244,
-0.02429969,
0.015857607,
0.024894012,
0.005193569,
-0.015222763,
0.0069630295,
-0.03203939,
0.0016234125,
-0.008469097,
0.02551535,
0.007739701,
-0.004187273,
-0.014925602,
0.00042674725,
-0.012615847,
0.010198035,
-0.00055042375,
0.034092505,
-0.027906148,
0.029824188,
0.0040488224,
0.013054836,
0.007098103,
0.015817085,
-0.036118604,
0.0009311617,
-0.007604628,
-0.005112525,
-0.026717503,
0.000049623613,
-0.011744625,
-0.02409708,
-0.014966124,
0.010826127,
0.0009961657,
0.026015121,
0.00022878042,
-0.0060479078,
0.022206053,
0.0074695544,
-0.008833795,
-0.006287663,
-0.04373674,
-0.014601425,
-0.016181784,
0.02004488,
0.0058250367,
-0.02606915,
-0.0013304722,
0.0060918066,
0.009968411,
0.006446374,
-0.008401561,
-0.013351997,
-0.011879698,
0.008820288,
-0.016532974,
-0.019936822,
0.013399273,
-0.0015305495,
0.025191173,
0.001005452,
-0.0053657875,
-0.016438423,
-0.006689506,
0.0050213505,
-0.029067777,
-0.020260997,
-0.035119064,
0.029337924,
0.0075708595,
0.053921267,
0.0069427686,
0.008252979,
0.01427725,
-0.009752293,
0.023989022,
-0.0060681687,
0.005115902,
0.022948956,
-0.014385308,
-0.0024161239,
0.031120893,
0.011548769,
0.041062288,
0.005234091,
-0.032984905,
-0.021274047,
-0.026136687,
0.035308164,
-0.027109215,
-0.0035726891,
-0.010772097,
-0.006929261,
-0.008570402,
0.0015736042,
-0.0048558856,
0.0060479078,
0.0072466834,
0.028527485,
0.001005452,
-0.0036739942,
-0.0015947093,
-0.0051969457,
-0.0042480556,
-0.013980089,
0.0059533566,
0.023097537,
0.002059868,
-0.007834252,
0.016924687,
-0.006750289,
0.030283438,
0.001090717,
0.0007732947,
-0.029905232,
0.024367226,
-0.008307009,
0.0032383827,
0.012757675,
0.0068144486,
0.022692317,
-0.0121093225,
0.016208798,
0.00527799,
-0.009583452,
0.00493693,
-0.007658657,
-0.009286291,
0.041575566,
-0.017073268,
0.016519466,
0.0037820528,
0.0026406834,
0.03765844,
-0.015020153,
-0.007456047,
-0.02369186,
0.004143374,
0.0037820528,
-0.0023198843,
-0.00096493,
0.0035220368,
0.041440494,
0.01868064,
0.0128252115,
-0.012379469,
0.0011683842,
0.0023924862,
0.008408314,
-0.0048795235,
0.005635934,
-0.0037043856,
-0.00609856,
-0.0067367814,
0.004751204,
0.016546482,
0.015533431,
-0.031769246,
0.0073007126,
0.00091849855,
-0.0046431455,
0.016546482,
-0.0008159272,
-0.000059727732,
-0.024407748,
-0.04079214,
0.017627068,
0.031120893,
-0.0038732274,
-0.008583909,
-0.038441867,
0.009921135,
0.01447986,
0.02879763,
0.0030779832,
0.0074695544,
-0.009900874,
-0.0049200454,
-0.0018454392,
-0.013716695,
0.025799004,
-0.03422758,
0.009212,
-0.006341692,
0.017816171,
-0.0014064509,
-0.014142176,
0.011373173,
0.039927673,
0.004768088,
0.010441167,
0.001536459,
0.008367792,
-0.02359731,
-0.009171478,
-0.02496155,
0.005234091,
-0.011812162,
-0.009205246,
-0.024353718,
-0.002407682,
-0.01346681,
-0.0065172873,
0.00043075724,
-0.012014772,
-0.027055185,
-0.009698264,
0.002557951,
0.008138168,
0.036631882,
-0.022395156,
0.013129126,
0.00073403906,
0.016573496,
0.011487986,
-0.02186837,
0.015195748,
-0.023327162,
-0.016343871,
-0.02065271,
0.0009151217,
0.0015660062,
0.0023435222,
0.031093877,
-0.015276792,
-0.01847803,
-0.005088887,
-0.0061728507,
-0.0017745257,
0.009380842,
0.042440034,
0.02743339,
0.0219224,
-0.0058520515,
0.020895842,
0.026541907,
-0.0028382281,
0.0038327053,
-0.02754145,
-0.0052036997,
0.0033092962,
0.014844557,
-0.00065215083,
-0.043358535,
0.020733753,
0.027879132,
-0.0072466834,
0.0073074666,
-0.0005727953,
0.016803121,
-0.0030999326,
-0.0041332436,
0.0219224,
0.006061415,
0.009934642,
0.0054434547,
-0.0054299473,
-0.017856693,
0.02901375,
0.0029935625,
0.010002179,
-0.011494739,
-0.0005314291,
-0.011359666,
-0.009576698,
-0.008388053,
-0.015776563,
-0.022989478,
-0.014088147,
-0.0030205771,
-0.025880048,
0.007152132,
-0.0014486613,
-0.012028279,
-0.0026102918,
-0.015452388,
-0.012622601,
-0.0115960445,
0.004930176,
-0.049679965,
-0.037496354,
-0.020976886,
0.01230518,
0.030715672,
0.03533518,
-0.009103942,
-0.019518094,
0.015425373,
0.0031894187,
-0.018505044,
0.0000043364603,
-0.026352804,
-0.028041221,
0.0047106817,
0.0017306269,
-0.0019079106,
-0.0326067,
0.009867106,
0.018667132,
-0.0033869634,
0.00974554,
-0.03203939,
-0.0047613345,
0.015803577,
0.0041771424,
0.04268317,
0.0042142873,
-0.0019636285,
-0.01278469,
-0.027744059,
-0.013912552,
-0.029283894,
-0.013858522,
0.0017407574,
-0.022300605,
0.013196663,
-0.018464522,
-0.01225115,
-0.0030796716,
-0.010366877,
0.005700094,
-0.016830135,
0.002481972,
0.014858065,
-0.019504586,
0.014763514,
-0.008455589,
-0.021449642,
0.009914381,
-0.026460864,
0.03341714,
0.01569552,
0.002525871,
0.036172636,
0.011494739,
-0.012798197,
0.003927257,
-0.0012967038,
0.014182698,
0.029445983,
0.004751204,
-0.015101197,
-0.005061873,
-0.011832423,
0.0032704626,
0.0048829005,
-0.011785147,
-0.016897673,
-0.002554574,
-0.00284667,
0.014885079,
-0.012176859,
0.010528965,
-0.028149279,
0.000547469,
-0.0028112135,
0.011548769,
-0.009826584,
-0.002769003,
-0.001155721,
-0.0125820795,
-0.016830135,
-0.01366942,
-0.03295789,
-0.00022477044,
-0.015317314,
0.0335252,
0.009765801,
0.059594348,
-0.0014824297,
0.0043561147,
0.037766498,
0.02743339,
-0.0024718416,
-0.013595129,
0.009272783,
-0.022246575,
0.0064531276,
-0.01447986,
-0.0011818915,
0.019018322,
-0.014439338,
0.0073479884,
0.025096621,
-0.020760769,
-0.020733753,
0.011244854,
-0.028608529,
-0.033633254,
0.012244396,
0.003977909,
-0.013054836,
-0.017843185,
-0.008854056,
0.011602798,
0.011859437,
0.02282739,
-0.016978716,
0.03417355,
-0.010333109,
0.0510307,
-0.029445983,
0.0346328,
-0.0048997845,
-0.002384044,
-0.015020153,
-0.005841921,
0.015519924,
0.016573496,
0.010177774,
0.007955818,
0.006851594,
-0.0045958697,
0.0051901923,
-0.022719331,
-0.0316882,
-0.0052205836,
-0.01447986,
-0.0070035513,
-0.023097537,
-0.0057102246,
-0.02424566,
0.002181434,
-0.0047005513,
-0.011400188,
0.023192089,
0.029040763,
-0.015357836,
0.032525655,
-0.0021746804,
0.033336096,
-0.016316857,
0.04449315,
0.016830135,
0.0033464413,
-0.010366877,
0.00007434309,
0.006665868,
0.002059868,
0.030418511,
0.024921026,
-0.007098103,
-0.019626154,
-0.010096731,
-0.0061762272,
-0.015790071,
-0.03122895,
0.015600968,
-0.0035861966,
-0.0017829678,
0.0022844274,
-0.005639311,
0.001718808,
-0.010772097,
-0.0069427686,
0.01293327,
0.010819373,
-0.020693231,
-0.014547396,
0.021260541,
-0.0130818505,
0.026514892,
-0.009320059,
-0.0043223463,
0.010765343,
-0.027649509,
0.011143548,
0.005298251,
-0.0041568815,
0.025880048,
0.021949414,
-0.026352804,
0.004524956,
0.004139997,
-0.0028568006,
-0.024272675,
0.0089350995,
0.04125139,
-0.0052712364,
-0.006061415,
0.0015263285,
0.003413978,
0.0019872661,
-0.008847302,
-0.0017019238,
0.0013059902,
-0.020288013,
0.00012177704,
0.005055119,
0.0029006994,
0.015682012,
-0.026595935,
-0.011656827,
0.019153396,
-0.032282524,
-0.017491994,
0.010238557,
-0.05937823,
0.004629638,
-0.007456047,
0.033228036,
0.026609443,
0.007273698,
0.0064801425,
0.00016388192,
0.04233198,
-0.002387421,
0.01002244,
0.009948149,
0.0027926408,
-0.021962922,
0.0067671733,
0.014452845,
-0.0072061615,
0.009367335,
-0.011650073,
-0.0091782315,
0.015384851,
-0.0070440737,
0.010650531,
-0.017248863,
-0.019666675,
0.023759397,
0.011460971,
0.013075097,
-0.008786519,
-0.00731422,
0.0099076275,
-0.015817085,
-0.0068178256,
0.023151567,
-0.007759962,
-0.016114246,
-0.0067030136,
-0.018761683,
-0.007699179,
-0.00751683,
-0.003555805,
-0.011251607,
-0.014655455,
0.004707305,
0.004886277,
-0.014155684,
-0.02146315,
-0.017816171,
0.012257904,
-0.0013194975,
-0.020031372,
-0.024529314,
0.0167626,
0.0044371583,
0.011521754,
-0.016505959,
-0.0054400777,
-0.026852576,
-0.010920677,
-0.038739026,
-0.0029378447,
-0.023907976,
0.032930873,
0.0030864254,
-0.010468182,
-0.012116076,
-0.02323261,
-0.040494982,
-0.024340212,
-0.0038867346,
0.015817085,
0.0023587178,
0.019234441,
-0.00020440391,
0.009144464,
0.017073268,
0.0327958,
0.01070456,
0.0010189593,
0.02343522,
-0.0027419883,
0.023921484,
0.015830593,
-0.02971613,
-0.0044743037,
0.01177164,
0.02135509,
-0.010940938,
0.0042987084,
-0.00044236513,
0.024434764,
-0.0007467022,
-0.0047410736,
0.0001463646,
0.024569836,
0.015871115,
-0.020733753,
-0.027298318,
0.0073074666,
0.00561905,
-0.010967953,
0.0014081394,
-0.002326638,
0.000069910995,
0.021530686,
-0.033957433,
-0.011575784,
0.019166904,
-0.020274505,
0.02166576,
0.01333849,
0.053435005,
0.021854863,
0.0038360823,
-0.0007711842,
-0.025488336,
-0.011872944,
-0.04949086,
-0.008462343,
0.012926516,
-0.010333109,
-0.02769003,
-0.016316857,
-0.0028432934,
-0.014196206,
0.0011565653,
-0.0035693124,
0.007118364,
-0.01908586,
0.023002986,
-0.008800027,
0.008246226,
-0.017397443,
0.008408314,
-0.013514086,
-0.02384044,
0.0067165205,
-0.022260083,
-0.012663123,
0.008516372,
-0.018923772,
-0.032255508,
-0.015898129,
-0.029500013,
0.020490622,
-0.004909915,
0.0059736175,
0.2077968,
0.013473563,
0.0026744516,
0.01938302,
-0.014034118,
-0.024326704,
0.008293502,
-0.004001547,
-0.0056561953,
0.0030661642,
0.013723449,
-0.008881071,
-0.010751836,
0.0028719965,
0.022233067,
-0.0070373197,
-0.02890569,
0.0038056907,
-0.020895842,
-0.001982201,
0.0045587244,
-0.028176295,
0.0057743844,
0.0043493607,
0.014925602,
-0.0015195748,
-0.0296621,
-0.02308403,
0.009995425,
0.011481232,
-0.0418187,
0.0040724603,
-0.00081508304,
-0.013297968,
0.0048761466,
0.010272326,
0.0000332407,
-0.0033869634,
-0.002193253,
0.00852988,
-0.024326704,
-0.025015578,
0.005372541,
-0.016722078,
0.0034882685,
-0.0059128343,
0.0052678594,
-0.013500578,
-0.005153047,
0.014912094,
-0.051219802,
0.027460406,
-0.0043932595,
0.03522712,
-0.0016487386,
-0.012392977,
0.014344786,
-0.020949872,
-0.011947235,
0.035875473,
0.011967496,
-0.0005791268,
-0.035713386,
-0.008914839,
-0.017221848,
0.032417595,
-0.019207425,
0.015290299,
0.029121807,
-0.040846173,
-0.0017086775,
0.021854863,
-0.016776105,
-0.0081921965,
-0.008833795,
-0.0094889,
0.031769246,
0.01156903,
0.035038017,
0.019855777,
0.0073007126,
0.013790986,
-0.02181434,
0.009083681,
0.0072534373,
-0.004771465,
0.004116359,
-0.009954903,
-0.030148365,
-0.03628069,
0.01442583,
-0.01070456,
-0.0051699313,
-0.003121882,
-0.0015896441,
-0.0018386855,
-0.021692775,
0.000006394218,
0.00711161,
-0.019882793,
-0.031201936,
0.06008061,
0.008232718,
0.0010881844,
-0.009549684,
0.021557702,
0.0016343872,
0.005956733,
0.0014976254,
0.0012055293,
0.0014123603,
-0.009434871,
0.01427725,
-0.0025697697,
-0.0036233417,
0.002606915,
0.029878218,
-0.023097537,
0.036848,
0.013784232,
-0.010184528,
-0.049869068,
0.0033700792,
0.019707197,
-0.016330363,
-0.020949872,
-0.0115960445,
-0.0007082907,
-0.0019720704,
-0.031039849,
-0.023934992,
0.003778676,
0.019099368,
-0.0066726217,
0.01908586,
-0.012717153,
0.022287097,
-0.008347531,
-0.0069360146,
0.012676631,
-0.0051462934,
-0.009232261,
0.03406549,
-0.0049571907,
-0.022057472,
-0.0069360146,
0.0074222786,
0.021084946,
-0.026285268,
-0.024569836,
-0.0056021656,
0.004447289,
0.0030307076,
-0.0050416114,
0.019761227,
-0.026690487,
-0.006270779,
-0.058189586,
-0.0016808186,
0.0046195076,
-0.035605326,
-0.0008948607,
0.013595129,
-0.006264025,
-0.010312848,
0.013041329,
-0.17084073,
0.0037685456,
0.009765801,
-0.025799004,
0.013885537,
0.038549926,
-0.0089215925,
0.003555805,
-0.011224593,
-0.00331605,
0.023043508,
0.01543888,
-0.043250475,
-0.043061372,
-0.0030712294,
0.01293327,
-0.017883707,
0.02338119,
0.009684756,
0.0071588857,
0.016587004,
-0.040738113,
0.01670857,
-0.012615847,
-0.006804318,
0.021382106,
-0.0005440922,
0.009029651,
0.0019079106,
-0.020315027,
0.0058689355,
-0.0015482779,
0.035254136,
-0.014709484,
0.005423194,
0.0038529665,
-0.0036942551,
0.0043189693,
-0.0014165815,
0.010414152,
0.00812466,
0.021395613,
0.015222763,
-0.016478945,
-0.004163635,
0.04171064,
0.0011084455,
-0.032066405,
0.037037104,
-0.007780223,
0.024529314,
-0.029175837,
0.016208798,
0.00073277275,
0.045438662,
0.0029969392,
0.0077532083,
0.042953316,
0.004788349,
-0.0023620946,
0.01171761,
-0.022854405,
0.05046339,
-0.012906255,
0.0025984729,
-0.041683625,
-0.01812684,
0.0047815954,
-0.041494522,
0.015398358,
-0.008739243,
0.011744625,
-0.0038732274,
-0.02070674,
0.020814799,
0.008205704,
-0.0059938785,
0.009212,
-0.011305637,
-0.009887367,
-0.017127296,
0.01042766,
-0.0061120675,
-0.016060218,
-0.008212457,
-0.015357836,
-0.0027875756,
0.006547679,
0.004481057,
0.012237643,
0.026690487,
-0.02111196,
-0.019058846,
-0.019099368,
0.021071438,
0.010184528,
-0.023151567,
-0.011636566,
0.0076316423,
-0.009495654,
-0.0018066056,
0.007219669,
-0.024461778,
0.02474543,
0.05421843,
0.016830135,
0.0017373805,
-0.019045338,
0.045600753,
-0.014304264,
0.004852509,
-0.0027774451,
0.0106370235,
0.039468423,
-0.011015229,
0.0316882,
-0.007341235,
0.0033717677,
-0.0036402259,
-0.0058723125,
0.060242698,
-0.0017897214,
-0.006909,
-0.0062809093,
-0.0123254405,
0.004606,
-0.10935536,
0.013250693,
-0.0053387727,
0.031472083,
-0.014034118,
0.012696892,
-0.008293502,
0.019801749,
-0.0031066863,
0.029581057,
-0.016735584,
-0.0040319385,
-0.0015980862,
-0.0041737654,
-0.010826127,
-0.010265572,
-0.0032451365,
-0.022043966,
-0.017937737,
0.022975972,
0.023880962,
0.009569945,
-0.006753666,
-0.018221391,
0.0031877302,
-0.007678918,
-0.017127296,
0.042602126,
0.009347074,
-0.0024583344,
-0.013493825,
-0.016681554,
0.018396987,
-0.012284918,
-0.03047254,
-0.02592057,
-0.03239058,
-0.044466134,
0.032120436,
-0.010900416,
-0.009049912,
0.0029766783,
0.024164617,
-0.0010755212,
0.028230323,
-0.014101654,
0.010008933,
0.025677437,
0.0009944773,
0.009623974,
-0.028176295,
0.0077532083,
-0.039549466,
0.0023418337,
0.006730028,
-0.005909458,
0.0077126864,
0.018532058,
0.011791901,
-0.006483519,
-0.016573496,
-0.011562276,
-0.015141719,
-0.01873467,
0.012791443,
0.00041429518,
-0.006996798,
-0.019342499,
0.027055185,
-0.027473914,
-0.004082591,
-0.0055515133,
-0.024070065,
-0.0012848849,
-0.033795346,
-0.0037921835,
-0.0019720704,
0.011325898,
0.015087689,
-0.0027352346,
-0.010252065,
-0.025474828,
0.02034204,
-0.01483105,
0.021044422,
0.012960285,
0.03984663,
-0.0033785214,
0.0024279428,
-0.018491536,
-0.02647437,
0.044790313,
0.016222306,
-0.04338555,
-0.017519008,
-0.0006036089,
0.003295789,
-0.006105314,
0.0058520515,
0.0038698504,
-0.021746805,
-0.012683384,
-0.08309711,
0.013054836,
-0.014966124,
-0.012676631,
0.022921942,
-0.017127296,
0.022867912,
-0.005014597,
0.00009138554,
0.032228492,
-0.009914381,
0.01862661,
0.0017812793,
-0.01184593,
-0.017046252,
-0.0040758373,
0.03927932,
0.010947692,
0.020625696,
0.03509205,
-0.01503366,
0.007408771,
0.03174223,
0.03209342,
-0.011096273,
-0.006969783,
-0.011758132,
0.0038664737,
-0.018261913,
-0.00040733046,
-0.0055109914,
-0.042629138,
-0.010468182,
0.0007357275,
0.017221848,
-0.0058047757,
-0.016519466,
0.012372715,
0.03239058,
0.03387639,
-0.028041221,
-0.029878218,
0.028284352,
0.02429969,
-0.002303,
0.004551971,
-0.0335252,
0.009765801,
0.0035321673,
-0.011406941,
0.027554957,
-0.0018184246,
0.017194834,
-0.027608985,
0.0026660096,
-0.011947235,
-0.005301628,
-0.009448378,
0.017748633,
-0.0037043856,
0.016330363,
0.010684299,
0.009981918,
-0.0011151991,
-0.006027647,
0.01777565,
-0.02693362,
-0.012642862,
0.009225507,
-0.035254136,
-0.039117232,
-0.0042514326,
0.008590663,
0.018586088,
-0.02111196,
-0.004308839,
-0.0163979,
-0.0020277882,
-0.0016082167,
0.017437965,
-0.0041805194,
0.005521122,
-0.013169648,
0.023354176,
0.037739486,
0.012555065,
0.00048541973,
0.021962922,
0.0022219562,
0.008232718,
0.0048356247,
0.026501385,
0.028122265,
0.02171979,
-0.00017749477,
0.02612318,
-0.04616806,
0.009840091,
0.006287663,
0.0030627875,
0.012426745,
-0.014209713,
0.00906342,
-0.016181784,
0.024326704,
0.010792358,
-0.009529423,
-0.037523367,
-0.0034511231,
-0.0076451497,
0.02658243,
-0.010292587,
0.0021746804,
0.005335396,
0.008293502,
0.018140346,
0.020760769,
0.0020868827,
-0.0006192267,
0.01746498,
0.0029445982,
0.029040763,
-0.018559074,
-0.0039340104,
0.044439122,
0.019342499,
0.024542822,
-0.021881877,
0.03401146,
-0.036766957,
0.031039849,
0.004389883,
-0.023826933,
-0.022246575,
-0.013926059,
0.013635651,
0.0030999326,
0.01593865,
-0.030715672,
0.10189931,
0.01503366,
-0.018964294,
0.018032288,
-0.012021525,
0.0108734025,
0.021652253,
0.008813534,
-0.01184593,
-0.038387835,
0.010339863,
-0.013649159,
0.01999085,
-0.018045794,
-0.013345243,
0.020760769,
0.008016601,
0.014506875,
-0.0130818505,
-0.013723449,
-0.004970698,
-0.03306595,
0.0068819853,
0.032174464,
-0.022543736,
-0.005764254,
0.031201936,
0.006956276,
-0.018586088,
-0.0054299473,
0.021787327,
-0.021193003,
-0.030553585,
0.005180062,
0.00058588054,
-0.0053151352,
0.0112381,
-0.00941461,
0.016370885,
0.0012257904,
0.012892748,
-0.0044945646,
0.0062370105,
-0.00092778483,
0.002493791,
0.00023468988,
0.0026406834,
0.013230432,
-0.002789264
] |
UNLABELLED Biomechanical studies suggest a suture bridge technique enhances rotator cuff tendon footprint contact area, holding strength, and mean contact pressure. Based on these studies, we asked whether (1) the suture bridge technique would provide a high rate of cuff integrity after surgery, (2) the status of the repaired cuff would change with time, (3) preoperative factors could predict postoperative cuff integrity, and (4) patients with retears had less favorable pain, functional scores, range of motion (ROM), and muscle strength compared with those with intact repairs. We prospectively followed 78 patients with arthro | [
-0.01225008,
-0.001328353,
0.015145803,
-0.013164881,
0.0022680874,
0.011892413,
-0.014664329,
0.0093612345,
-0.023716044,
-0.014306662,
-0.0027873917,
0.0135294255,
0.021102326,
-0.0010515053,
-0.0065858793,
-0.00853585,
0.026508594,
0.03210745,
-0.0007290895,
-0.02701758,
-0.02495412,
-0.007180844,
-0.016136264,
-0.006716565,
-0.00593245,
0.020331968,
0.027925504,
-0.039095707,
0.00417163,
-0.013323079,
-0.0031364604,
0.028613323,
-0.04597391,
-0.007875542,
-0.043772884,
-0.012772823,
0.003562909,
-0.0011718739,
0.011589772,
-0.0028733693,
0.024582697,
-0.010764387,
-0.0023592236,
-0.016851597,
-0.016617738,
-0.004814742,
-0.0007200619,
-0.0065514883,
-0.006444876,
-0.004883524,
0.015090778,
-0.0005137158,
-0.05480552,
0.012738432,
0.01775952,
-0.0040959697,
0.0015819867,
0.03375822,
0.009973395,
-0.02005684,
-0.0021649143,
0.015888648,
-0.017814545,
-0.0099802725,
-0.008982933,
0.012951656,
-0.0027151706,
0.009161767,
0.005904937,
0.004904159,
0.029988965,
0.038600475,
0.012105637,
-0.0221203,
0.02055207,
-0.016659008,
-0.009794561,
-0.017291803,
0.0035491528,
0.015943674,
0.010186618,
-0.021157352,
0.015778597,
0.008790343,
0.0011856302,
-0.009498798,
0.02774667,
0.002782233,
-0.003122704,
-0.0006138796,
0.0043573417,
0.035188887,
-0.012580234,
-0.0009853026,
-0.019534096,
0.030759323,
-0.017443122,
0.02151502,
-0.0019499705,
-0.018928815,
-0.0009792842,
-0.014691842,
0.0058464725,
-0.023124518,
-0.025669454,
-0.0156135205,
0.02357848,
-0.00019721097,
0.014705597,
-0.03139212,
-0.02778794,
0.019424045,
-0.040003628,
-0.0051380177,
0.0140109,
-0.007627927,
-0.002154597,
0.00012251799,
0.015448444,
-0.011775483,
0.032162476,
-0.012724675,
0.032547656,
-0.028943477,
0.014114073,
0.019878006,
-0.02055207,
0.03367568,
0.013054829,
-0.007435337,
-0.016053725,
0.024885338,
0.016356366,
0.017346827,
-0.0075178756,
0.009595093,
-0.0057398602,
-0.0006590178,
-0.04033378,
-0.05783193,
0.003299818,
-0.00003602996,
-0.027416516,
-0.03601427,
0.0016309939,
0.013570694,
0.042039577,
0.012917265,
0.012862239,
-0.0017462038,
-0.022808122,
-0.011858022,
-0.013164881,
0.02656362,
-0.0016413112,
-0.029713837,
-0.0011254459,
0.026247222,
-0.025050415,
-0.022381673,
-0.012284471,
0.0034115887,
0.015228341,
0.012181297,
0.027155146,
0.007820517,
-0.010881317,
-0.020717148,
0.012036855,
-0.006300434,
-0.00034691935,
0.006919472,
-0.012311983,
0.007380312,
0.010152227,
0.01737434,
-0.000016993998,
-0.0061628697,
-0.010888196,
-0.023289595,
-0.03659204,
-0.010324183,
0.034858733,
0.042122114,
-0.018309776,
-0.008893517,
0.0088041,
0.012270714,
0.021226134,
-0.013309322,
-0.01799338,
0.007854908,
0.007566023,
0.0002863052,
-0.6360962,
-0.014292906,
0.023867365,
-0.019919276,
0.028640836,
0.016782815,
0.0037107905,
0.0045155403,
-0.0069641806,
0.029603785,
0.007050158,
0.015008239,
0.013082342,
-0.009196158,
-0.008900395,
-0.02617844,
0.014444226,
-0.0058533507,
0.006214456,
0.0053374856,
-0.030374143,
0.030071503,
0.0031381801,
0.032217503,
0.03188735,
-0.0024520794,
0.017126726,
0.008047498,
-0.00405814,
0.0031244238,
-0.027870478,
0.034583606,
-0.0031295824,
0.019080134,
0.048119906,
-0.014127829,
-0.02763662,
0.02304198,
0.005423463,
0.0170717,
-0.0029387122,
-0.032052424,
0.02472026,
-0.0059152544,
-0.010674971,
0.0077104657,
0.0041097263,
-0.012112515,
0.0060321838,
-0.022024006,
-0.0082676,
0.00765544,
-0.01526961,
0.02388112,
0.009306208,
-0.037720066,
0.036096808,
-0.018378558,
0.03100694,
-0.0019276164,
0.0038517937,
0.0139214825,
0.005117383,
-0.01848861,
-0.0070432797,
-0.0053271684,
0.002139121,
0.006444876,
0.02461021,
-0.011871778,
0.023110762,
0.02216157,
0.016796572,
-0.004336707,
-0.00038152531,
0.032382578,
0.015324636,
0.0063073123,
-0.012676528,
0.01771825,
-0.0046978127,
0.0028510152,
0.0114797205,
0.017525662,
0.030043991,
0.012311983,
-0.043085065,
0.017195508,
-0.013185515,
-0.025628185,
-0.0040512616,
0.03708727,
-0.023826094,
-0.021102326,
0.01002842,
0.03268522,
-0.016315097,
-0.00024697048,
0.026893774,
-0.028640836,
-0.021528775,
0.02273934,
0.004838816,
0.00088470883,
0.005530075,
0.0015854258,
-0.010221009,
0.0051414566,
0.038765553,
-0.04236973,
-0.0034941272,
-0.00895542,
0.019699173,
-0.004003114,
0.016851597,
-0.029191094,
0.030209066,
0.0038758675,
0.010262279,
-0.02924612,
0.0113490345,
-0.004598079,
0.029438708,
-0.0028200631,
0.009024202,
0.013254297,
0.000554985,
-0.017016673,
0.00031553756,
-0.012951656,
0.0008451592,
0.012738432,
0.0036832776,
-0.011410939,
0.009209914,
0.018997597,
0.006720004,
-0.0067268824,
0.003552592,
-0.024431378,
-0.024059953,
0.009072349,
0.012112515,
-0.0052033607,
-0.047267012,
-0.03970099,
-0.025091683,
-0.0049763797,
0.005179287,
0.010090324,
0.015916161,
-0.02503666,
-0.009203035,
-0.0051999213,
-0.010055933,
-0.007256504,
-0.019382777,
-0.029438708,
-0.008797222,
-0.019011352,
-0.008198818,
0.014292906,
-0.02170761,
-0.011830509,
-0.015764842,
-0.034666143,
0.0011847705,
-0.004804425,
-0.007875542,
-0.044460703,
0.0040787742,
-0.012085003,
-0.01634261,
0.0011675749,
-0.015338393,
0.000643112,
-0.0099802725,
-0.013460644,
0.030566733,
-0.007889299,
-0.009918368,
0.0055369535,
-0.014334175,
0.012483939,
0.013976509,
-0.004653104,
0.011101419,
-0.0052033607,
-0.0043951715,
0.027003825,
-0.0055060014,
-0.0014719354,
-0.015833624,
0.025353055,
-0.01381831,
-0.01324054,
-0.028998503,
-0.00058378745,
-0.013694502,
0.024458889,
0.037252348,
-0.010035298,
0.03562909,
-0.030154042,
0.008130036,
0.0006663259,
0.0021752317,
-0.012153785,
0.022890659,
-0.027815452,
-0.0014513008,
-0.023509698,
-0.010661215,
-0.033400554,
-0.010276035,
0.030649273,
0.024183761,
0.011005125,
0.0019585683,
0.0011856302,
-0.00853585,
-0.0092305485,
0.021391211,
0.015393418,
-0.022629287,
0.009072349,
0.00792369,
-0.013446887,
0.0049660625,
-0.014911944,
-0.006180065,
0.031969886,
0.037224833,
0.00910674,
0.030841863,
0.028723376,
0.0065170974,
-0.0039446494,
0.04347024,
0.02074466,
0.031254552,
0.040168706,
-0.016617738,
-0.031282067,
0.03571163,
0.0280218,
0.02740276,
-0.0006439717,
0.0258758,
-0.014004021,
-0.0013807992,
0.012470182,
-0.025518132,
0.0040203095,
0.0091342535,
0.010613067,
0.007930568,
-0.0062832385,
0.023124518,
0.017044187,
0.02078593,
0.031282067,
0.012098759,
0.0014229282,
0.020139378,
-0.007978715,
0.012215689,
0.003012653,
-0.024293812,
-0.011273375,
-0.0015226621,
-0.026604889,
0.036564525,
-0.016521443,
0.014925701,
0.00443988,
0.018584905,
0.036041785,
-0.0086115105,
-0.0073390426,
-0.017732007,
-0.05549334,
0.012841605,
0.008143792,
0.0041957037,
-0.004917915,
-0.008212575,
0.022904417,
-0.029438708,
0.012965413,
0.012676528,
0.0044708317,
0.008941663,
0.004298877,
0.011844265,
0.0073184078,
0.029576272,
-0.015599764,
0.002809746,
-0.039398346,
-0.0016739826,
0.009443773,
-0.001661086,
-0.0192177,
0.03188735,
0.010392965,
-0.023028223,
-0.02897099,
-0.014402957,
-0.0037417423,
0.023853607,
0.011727336,
-0.009959638,
-0.0023007588,
0.0114453295,
0.010200375,
-0.018543635,
-0.012243201,
0.0038345982,
-0.008109401,
-0.017690739,
-0.0066821743,
-0.0054750494,
-0.0047631557,
0.042012062,
0.022794364,
0.02430757,
0.019960545,
0.009141131,
0.0039824797,
0.009519433,
-0.06201388,
-0.005186165,
-0.007249626,
0.0007871243,
0.0010016382,
0.021680096,
0.005653883,
0.0011168482,
0.007070793,
0.01810343,
-0.009546946,
0.00543378,
-0.006214456,
-0.005217117,
-0.00085891556,
0.020675877,
0.046304062,
0.020483289,
-0.0073321643,
0.015819866,
0.02411498,
0.010936343,
-0.020937249,
-0.011438452,
0.01799338,
0.00027491318,
0.0028854061,
-0.0130754635,
-0.02461021,
0.014471739,
-0.011562259,
0.008934786,
0.0037211077,
0.00071318366,
0.013329958,
0.026838748,
0.016411392,
0.01718175,
-0.02170761,
0.019424045,
-0.012291349,
-0.011569138,
-0.015558495,
0.006613392,
-0.016383879,
-0.0077173435,
-0.025119197,
0.010798778,
0.0016791413,
0.012126272,
0.00075230346,
-0.002575887,
-0.014980726,
-0.01726429,
-0.014829406,
0.030456683,
-0.009725779,
-0.004993575,
-0.030209066,
-0.02035948,
0.011156445,
-0.0076485616,
0.002266368,
-0.020015571,
0.0012054051,
-0.016411392,
-0.0018433584,
0.030346632,
0.0071739657,
0.026769966,
0.004945428,
-0.012800336,
0.01726429,
0.008742196,
-0.011624163,
-0.0006706248,
-0.013653233,
-0.009044837,
0.00145474,
-0.032822784,
-0.018227238,
0.003452858,
0.023757312,
0.043002523,
-0.0041269218,
0.024183761,
-0.010901951,
0.015489713,
0.0058533507,
0.025270518,
0.018089674,
0.0076416833,
-0.029576272,
0.0036213738,
-0.015021996,
0.0020445457,
-0.019740442,
-0.002672182,
0.018516121,
-0.013990264,
0.007359677,
0.004979819,
-0.025600672,
0.009643241,
-0.023839852,
0.0019430923,
-0.0054716105,
0.0057054693,
0.0052652643,
-0.0165352,
0.0019895202,
0.03923327,
-0.0077173435,
-0.0021597557,
-0.009471285,
0.035546552,
-0.008233209,
-0.011548502,
0.0066993698,
0.0020617414,
-0.03670209,
-0.029878914,
-0.0026085584,
-0.031777296,
0.043745372,
0.008721561,
-0.043690346,
-0.007916812,
-0.02276685,
-0.0036316912,
0.0049007195,
-0.009801439,
-0.002660145,
-0.016218802,
0.0072289915,
0.018873788,
-0.0072289915,
0.012071246,
-0.024238788,
0.0009638082,
0.026494838,
-0.00841892,
0.0029215168,
-0.006204139,
0.0024004928,
0.0063210684,
-0.0070329625,
-0.008185062,
-0.028420735,
-0.00841892,
-0.025504377,
0.025628185,
-0.00765544,
0.013976509,
0.018543635,
-0.008068132,
0.015971188,
-0.005595418,
0.0072289915,
-0.017030431,
0.010434234,
-0.009780805,
0.029301144,
0.009058593,
0.013887092,
0.0067887865,
-0.005997793,
0.003796768,
0.020153135,
-0.013034195,
-0.0033995518,
-0.026150927,
-0.046689242,
-0.012470182,
-0.010310426,
0.01389397,
-0.014815649,
-0.05194419,
-0.0018192846,
0.01741561,
-0.008322625,
-0.004604957,
-0.015228341,
0.030649273,
0.004611835,
0.01526961,
-0.027911747,
0.016094996,
-0.020827198,
-0.010778144,
-0.018516121,
-0.0039824797,
0.035766654,
-0.0062316516,
0.009822073,
0.0089072725,
-0.001932775,
-0.041654397,
0.00056702184,
-0.02357848,
-0.01775952,
-0.009553824,
-0.00023751294,
-0.008212575,
-0.0053649982,
-0.011589772,
-0.013068586,
-0.0018553953,
0.0059221326,
-0.024170006,
0.03191486,
0.0042816815,
0.013515669,
0.017621957,
-0.015723571,
0.032987863,
0.01756693,
0.012580234,
0.029851401,
-0.023509698,
-0.009395625,
-0.005220556,
0.031364605,
-0.010303548,
0.018364802,
0.025779504,
-0.020153135,
-0.02813185,
0.008047498,
-0.00914801,
-0.024789043,
-0.022863146,
0.02778794,
0.016301341,
-0.009794561,
-0.0022216595,
-0.014127829,
-0.014884431,
0.014595547,
-0.014843162,
-0.007889299,
0.012958534,
-0.018571148,
-0.0062007,
0.03161222,
-0.023358377,
0.0043882933,
-0.020098109,
-0.008941663,
-0.022601774,
-0.008164427,
-0.00279427,
0.0052377516,
0.017635712,
0.028255658,
-0.022698069,
0.002560411,
-0.0024004928,
-0.0040443833,
-0.0023781387,
-0.023454672,
-0.0055025625,
0.040581398,
-0.021721365,
-0.008412043,
0.0022268181,
-0.021638826,
-0.0019757638,
0.003490688,
-0.0077104657,
-0.010750631,
-0.021721365,
-0.005533514,
0.03893063,
0.03130958,
-0.020730903,
0.016934136,
-0.009780805,
0.0031313018,
-0.028420735,
-0.005898059,
-0.0049901363,
-0.03356563,
-0.050733626,
0.013109854,
0.028076824,
0.012305105,
-0.00022741058,
-0.017938353,
-0.0049351105,
0.010248522,
-0.01071624,
0.023908634,
0.030319119,
-0.004639348,
-0.014114073,
0.012573355,
-0.01956161,
-0.02774667,
-0.0042163385,
-0.022794364,
-0.008810978,
-0.005151774,
0.01526961,
0.0025982412,
0.007889299,
-0.012992925,
0.016026212,
-0.024390107,
0.004467393,
0.0005334906,
-0.021652583,
-0.007084549,
0.019822981,
-0.024183761,
0.020565826,
-0.02201025,
0.00079056347,
-0.0075729014,
0.003375478,
0.018571148,
-0.011555381,
0.0045464924,
-0.010282913,
0.01642515,
-0.04225968,
-0.04404801,
-0.015049508,
-0.0039446494,
-0.011686067,
0.015145803,
-0.004099409,
-0.021047302,
0.0037211077,
0.009278696,
-0.0005223135,
0.0012234603,
-0.02035948,
-0.022532992,
0.025903312,
-0.0074766064,
-0.013770162,
0.0017934914,
-0.017594444,
0.044598266,
0.018020893,
-0.004653104,
-0.023743557,
0.00221994,
-0.055108164,
-0.025628185,
0.013027316,
0.009354356,
0.010881317,
-0.012483939,
0.026948798,
0.021721365,
-0.0062316516,
0.02564194,
0.016975405,
-0.039453372,
0.02246421,
0.0015802671,
0.025958339,
0.019272724,
-0.05274206,
0.0003000616,
0.011472843,
0.00020731334,
0.005633248,
0.020579584,
0.021886442,
-0.0064208023,
0.0065377317,
0.024706505,
0.017333072,
0.008198818,
0.01726429,
-0.020290699,
0.00646895,
0.006599636,
0.0034683337,
-0.012318862,
0.0088041,
0.0101109585,
0.0068266164,
0.018172212,
-0.0069985716,
-0.033015374,
0.02544935,
-0.03130958,
0.020373236,
0.0036213738,
-0.00417163,
0.0060184277,
0.008301991,
-0.0036041783,
-0.0039446494,
0.019341506,
0.007222113,
0.0069641806,
0.016755302,
-0.021157352,
-0.016191289,
-0.009196158,
0.0049695014,
0.0047665946,
-0.0076072924,
-0.007084549,
-0.010509894,
0.0038793064,
-0.0069641806,
0.015819866,
0.017016673,
-0.021638826,
-0.016287584,
-0.017044187,
0.016205046,
0.0058533507,
-0.000070447844,
-0.025201736,
0.0029266754,
-0.004842255,
-0.011294009,
0.015228341,
0.016397636,
0.012738432,
-0.0012165821,
0.024431378,
0.19545102,
-0.012002464,
-0.025022902,
0.008460189,
0.007215235,
-0.0159987,
0.02346843,
0.009773927,
-0.010736875,
0.01821348,
0.02897099,
-0.0014272272,
-0.012408278,
-0.002828661,
0.015971188,
0.00005094169,
-0.00037765634,
-0.002419408,
-0.0089072725,
0.016356366,
0.0029438708,
-0.0016980564,
0.027499055,
-0.0028802475,
0.018117186,
0.00078368525,
-0.008700927,
-0.03053922,
-0.0058671073,
0.01623256,
-0.015586007,
-0.0036110566,
0.0075041195,
0.0047356426,
0.003972162,
-0.008240087,
0.00887976,
-0.0036867168,
0.006334825,
-0.0024864704,
0.013522547,
-0.006840373,
0.01932775,
-0.012298227,
0.0070123277,
-0.0064483155,
-0.004718447,
0.0028011482,
-0.008281357,
0.019575365,
-0.020276941,
0.005657322,
0.01423788,
0.00090448366,
0.002354065,
-0.016521443,
0.01642515,
0.006513658,
0.021652583,
-0.007724222,
-0.029823888,
0.0061835046,
-0.010895073,
0.026701184,
-0.052797087,
0.0127797015,
0.00023600833,
0.028998503,
0.008308869,
-0.017869571,
0.01634261,
-0.04110414,
-0.027650375,
0.031364605,
-0.024335083,
-0.013109854,
0.020992275,
0.00063967286,
0.008315748,
0.0019465315,
-0.0012483938,
-0.0176082,
0.0004348314,
-0.00440205,
-0.020153135,
-0.010007786,
0.021116083,
0.005629809,
0.007160209,
-0.0074972413,
-0.0025621306,
-0.015393418,
0.0029301145,
-0.03433599,
0.014691842,
0.001473655,
-0.011741092,
-0.0004500924,
-0.012841605,
0.03356563,
-0.027966773,
0.040031143,
0.0044364408,
0.0001840994,
0.018020893,
-0.0062110173,
-0.02544935,
0.025930826,
-0.0068885204,
0.0013498473,
-0.0052618254,
-0.019836737,
0.008941663,
-0.016328854,
0.006840373,
0.021198621,
0.0012217409,
-0.025215492,
0.009478164,
0.0035973,
0.023743557,
-0.023440916,
0.008405164,
0.006159431,
-0.0037451815,
-0.010049054,
-0.011947438,
-0.00092683785,
0.0041509955,
-0.036537014,
0.015861137,
-0.009216792,
0.009354356,
-0.007854908,
0.01064058,
0.009072349,
0.02231289,
-0.022189083,
-0.024004929,
0.016328854,
-0.00424729,
-0.010441112,
-0.027609106,
0.005392511,
0.0072702607,
0.0003080145,
0.009065472,
0.00078927376,
-0.015599764,
-0.00040817834,
-0.0053065335,
0.017828302,
0.00093027693,
-0.0010901951,
-0.0053065335,
-0.009464407,
-0.030594246,
-0.02503666,
0.0021838294,
0.01829602,
-0.026591133,
0.0013670429,
0.003958406,
-0.015641034,
-0.019492827,
0.001465917,
-0.17542168,
0.007039841,
0.031584706,
-0.029851401,
0.031722274,
-0.008742196,
0.03766504,
0.027719159,
-0.008969177,
-0.01266965,
0.012986047,
0.012862239,
-0.0050348444,
-0.031859837,
-0.0007406965,
0.020772172,
-0.006173187,
0.0055816616,
0.011961195,
0.0042954376,
0.015242098,
-0.028338196,
0.013082342,
-0.0043298285,
0.012538964,
-0.0024555183,
0.011727336,
0.011713579,
0.03623437,
-0.010860682,
-0.026233466,
0.0043573417,
0.041131653,
-0.020125622,
-0.00092339877,
-0.006173187,
0.0025741674,
0.00020193974,
-0.0029387122,
0.019231455,
0.020153135,
0.023344621,
-0.0063554593,
-0.0066477833,
0.0018089673,
0.01423788,
0.03637194,
-0.01780079,
0.02422503,
-0.003000616,
-0.012917265,
-0.0040512616,
0.015984943,
0.004233534,
0.0062488476,
-0.00045568094,
-0.005354681,
0.00037722645,
-0.011720458,
-0.003200084,
0.011390304,
-0.0037314252,
0.016906623,
0.00049007195,
-0.030291606,
-0.026013363,
0.0015123449,
-0.018117186,
0.0025311788,
0.01936902,
-0.03271273,
-0.012697163,
-0.009251183,
-0.035106346,
0.020772172,
0.027457787,
-0.005148335,
0.01064058,
0.019341506,
-0.014829406,
-0.010613067,
0.007153331,
-0.0017057944,
-0.019245211,
0.0045912005,
0.0070983055,
0.008040619,
0.011342157,
0.0021270842,
0.013206149,
0.026316004,
-0.0395084,
0.00998715,
-0.019575365,
0.008652779,
0.018461097,
0.0023850168,
-0.014347931,
-0.01098449,
-0.018887546,
0.01159665,
-0.028503273,
0.0008159268,
0.009058593,
0.0043160724,
0.00050769735,
-0.027870478,
0.0031588147,
0.007153331,
0.0029215168,
-0.022340404,
-0.0077586127,
0.027856722,
0.021528775,
-0.009505676,
0.034803707,
-0.0011821911,
0.012511451,
0.0049351105,
-0.01477438,
0.061133467,
0.009292453,
-0.017209264,
0.0012260397,
0.010585554,
-0.011974951,
-0.12986048,
-0.025077928,
0.011438452,
0.023550967,
-0.0021803903,
0.01829602,
-0.0025586914,
0.017690739,
-0.0044226847,
0.019699173,
-0.015627276,
-0.047294524,
0.012291349,
-0.015159559,
-0.001932775,
-0.003222438,
-0.007586658,
-0.03670209,
-0.003958406,
0.009079228,
0.0040787742,
0.002216501,
0.0052652643,
-0.023413403,
-0.010530529,
-0.009870221,
-0.032795273,
-0.0015389979,
0.010551163,
0.011754849,
0.01683784,
0.006173187,
0.0037417423,
-0.017209264,
0.0031141064,
-0.030346632,
-0.03309791,
-0.013522547,
0.018529879,
0.008866004,
0.0028269414,
-0.009856464,
0.026343517,
-0.015063264,
-0.016906623,
-0.01623256,
-0.039563425,
0.0021081693,
-0.021982737,
-0.002966225,
0.0038105245,
-0.0049901363,
-0.001515784,
-0.005430341,
0.030649273,
-0.019960545,
-0.01863993,
-0.0165352,
-0.022367915,
0.0024348837,
-0.021446237,
0.011486599,
-0.026838748,
0.025311787,
0.021941468,
-0.010482381,
-0.0009448931,
-0.018034648,
0.01163792,
-0.0033118548,
0.0066993698,
0.029713837,
-0.010812535,
0.015833624,
-0.032382578,
-0.0035732265,
-0.037032243,
-0.037802603,
0.011768606,
-0.012738432,
-0.0006792225,
-0.004123483,
0.025119197,
-0.032327555,
0.007125818,
0.027911747,
-0.018158456,
0.009663875,
0.023716044,
-0.00271689,
-0.006905716,
0.015737329,
0.009581337,
-0.0027495616,
-0.004598079,
0.004842255,
-0.027719159,
0.0031175455,
0.00011886394,
-0.009292453,
-0.052219316,
0.00025234406,
-0.04655168,
0.024142493,
0.019011352,
0.0024589575,
0.0069916933,
0.0021993055,
0.015489713,
0.0027392444,
0.004543053,
-0.0002671752,
-0.028833427,
0.0063932897,
0.0065824403,
-0.012717797,
-0.02392239,
0.0052962163,
0.029741349,
-0.0026739014,
0.044158064,
-0.0021683534,
-0.00895542,
-0.0055403924,
-0.0096226055,
0.029191094,
-0.0032860613,
0.01423788,
-0.01994679,
0.022134056,
-0.012827848,
-0.009292453,
0.008240087,
-0.030264093,
-0.006781908,
0.011211471,
-0.0040203095,
-0.033895783,
-0.002529459,
0.036041785,
0.025201736,
0.003425345,
-0.023743557,
-0.01818597,
0.015365905,
0.009464407,
0.009374991,
0.006001232,
-0.041049115,
0.01098449,
0.00055412523,
-0.025284274,
0.02626098,
0.0024176883,
0.012504573,
-0.018571148,
-0.015187072,
-0.016315097,
0.004371098,
-0.0045946394,
-0.0018467975,
-0.028310683,
0.048945293,
-0.00899669,
0.0006207578,
-0.01262838,
0.006073453,
-0.004113165,
-0.011741092,
0.0021563165,
0.030209066,
-0.00011488748,
-0.040223733,
-0.0008378511,
0.0077586127,
0.009168644,
0.008549606,
-0.0054509756,
-0.016081238,
0.0033823564,
0.0029799815,
0.014911944,
0.019905519,
-0.0076072924,
-0.023413403,
-0.0029404317,
0.010227888,
0.0057054693,
0.0040443833,
0.020029327,
0.028915966,
0.005289338,
-0.0026137172,
0.03246512,
-0.01462306,
-0.009918368,
-0.0046015177,
0.022615531,
-0.020909738,
-0.004959184,
0.005444098,
0.008370773,
-0.014856919,
0.014980726,
-0.019630391,
-0.03540899,
-0.021638826,
-0.0011039516,
-0.024775287,
-0.041159168,
-0.017814545,
0.031227041,
0.023014467,
0.010998246,
0.020125622,
0.0016447502,
0.01580611,
-0.0067578345,
-0.028338196,
-0.041846987,
0.000104516446,
0.014265393,
0.014251636,
0.011170202,
0.005392511,
0.022024006,
0.002388456,
0.022436697,
0.006173187,
-0.012188176,
0.00058507716,
0.0044949055,
0.04880773,
0.005399389,
-0.021198621,
-0.0038586718,
0.006843812,
-0.019080134,
-0.0023936147,
0.01511829,
0.0077173435,
0.074119516,
0.01343313,
0.0005807783,
0.007841151,
-0.033813246,
0.014760624,
0.0032516704,
0.011307766,
-0.0027684767,
-0.011355913,
0.02583453,
-0.007345921,
0.004377976,
0.00968451,
-0.038215294,
0.012614625,
0.013474399,
0.02112984,
-0.0062832385,
-0.015902406,
-0.0043917326,
-0.025518132,
0.0009878819,
-0.017167995,
-0.013749528,
-0.006169748,
0.0022801242,
-0.030676786,
-0.002017033,
-0.0067371996,
-0.011149567,
-0.002962786,
-0.046111472,
-0.011713579,
0.024280056,
-0.00048104432,
-0.025944581,
-0.012119394,
-0.002407371,
0.017429367,
-0.0064551933,
0.008577119,
-0.00020097248,
-0.014526765,
-0.032602683,
0.011871778,
0.0026584254,
0.013488156,
-0.010674971
] |
Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may be a risk factor for human colon cancer. It is not known whether this age-related DNA methylation phenomenon is specific to human tissues. We performed comprehensive DNA methylation profiling of promoter regions in aging mouse intestine using methylated CpG island amplification in combination with microarray analysis. By comparing C57BL/6 mice at 3-mo-old versus 35-mo-old for 3627 detectable autosomal genes, we found 774 (21%) | [
-0.0057468773,
-0.01792114,
0.022622835,
-0.022245137,
-0.046834607,
0.02047386,
-0.012509633,
0.004649598,
-0.008472167,
0.011519803,
0.011422122,
0.00851124,
-0.0069809095,
-0.009331756,
-0.010438804,
0.017699732,
0.04011418,
-0.005248706,
-0.027819445,
0.017322032,
-0.05449277,
0.04352649,
-0.002165254,
-0.024941122,
-0.024068508,
0.02831436,
0.006612979,
-0.0611611,
-0.0056068683,
-0.019080283,
0.023456376,
0.0020903656,
-0.017530417,
-0.0064762263,
-0.021216234,
0.00073504675,
0.016475467,
-0.012991524,
0.009624799,
-0.035243172,
-0.0014179972,
0.007892596,
-0.0060496875,
-0.005558028,
-0.0109076705,
0.0067855483,
0.008628456,
-0.022375377,
-0.0067334515,
-0.00005840488,
0.0025901648,
0.017426224,
-0.009859232,
0.004662622,
-0.0032462531,
-0.019939873,
0.023860123,
0.017517393,
-0.027090097,
-0.00739768,
0.010829526,
-0.0017240632,
-0.018129526,
-0.009585726,
0.0012608942,
0.0068962527,
-0.0053203385,
0.009357804,
0.007065566,
0.009019178,
0.031674575,
0.027897589,
-0.0036272076,
-0.0014969558,
0.01792114,
-0.0059552626,
-0.022088848,
0.005541748,
0.011623995,
0.008413559,
0.03188296,
-0.020304548,
0.0025966768,
0.021229258,
0.012672435,
0.02582676,
0.0062352805,
-0.018637465,
0.015511685,
0.0007912131,
0.007697234,
0.024003388,
0.0234694,
0.021307403,
-0.006157136,
0.008582871,
0.007912131,
0.031622477,
0.022596788,
-0.011396074,
-0.017374128,
0.011370026,
0.013056645,
-0.004913336,
-0.040921673,
0.0059552626,
0.018884923,
-0.0019471006,
0.013961819,
-0.008934522,
-0.007260927,
0.024784833,
-0.008087956,
-0.019471006,
0.02063015,
-0.005792462,
0.010145762,
0.01594148,
-0.003728144,
0.007710258,
0.014560927,
0.033914715,
0.0075930413,
-0.015029794,
0.005030553,
0.008862889,
-0.021046922,
0.0029434431,
-0.012366368,
-0.009429437,
0.0023345673,
0.00093366404,
0.012620338,
0.016957358,
-0.025957001,
0.010432292,
0.002593421,
-0.033185367,
-0.019288668,
-0.030893128,
0.00985272,
0.01686619,
-0.022232112,
-0.007925156,
0.0011387934,
0.0065511144,
0.013610168,
-0.012574754,
0.020552006,
0.009325244,
-0.011877965,
-0.023651738,
-0.00070004456,
0.0004171777,
0.017191792,
0.0327165,
0.00867404,
0.013519,
-0.007677698,
-0.012438001,
0.020096162,
-0.008752185,
0.0073130233,
0.034097053,
-0.0033374217,
0.0184942,
0.0015278879,
-0.00071998767,
-0.013414807,
-0.018272791,
-0.0033064894,
0.008087956,
-0.023495449,
0.014365565,
-0.026803566,
0.006127832,
-0.022805173,
0.02573559,
-0.023808027,
-0.04243247,
-0.026347723,
0.038082425,
0.001382181,
0.0054896516,
-0.009742015,
-0.007104638,
0.0005282894,
0.0070264935,
-0.008061908,
-0.022375377,
-0.010126226,
0.006150624,
0.0032088088,
-0.0017712755,
-0.6430772,
-0.03568599,
-0.006902765,
-0.025957001,
0.00083028537,
0.025436036,
0.017712755,
0.006319937,
-0.013519,
0.026386796,
-0.012783139,
0.03430544,
0.021763245,
-0.017647635,
-0.0028408784,
-0.035816234,
-0.012438001,
-0.011584924,
0.038030326,
0.0076125776,
-0.02120321,
-0.010725333,
0.012073327,
0.024120605,
0.002932047,
0.010308563,
0.01941891,
-0.011265833,
0.009403389,
0.030085636,
-0.037014447,
0.021893486,
-0.020187331,
-0.009995985,
0.045506153,
-0.005082649,
0.019457983,
0.02391222,
-0.0029857713,
0.034644064,
0.021541836,
-0.0060268953,
0.02082551,
0.020252451,
-0.037613556,
0.013017572,
0.015472612,
0.008713112,
0.037795894,
-0.011370026,
-0.014769312,
0.025136484,
-0.010933719,
-0.024003388,
0.026061194,
0.0073325597,
0.02391222,
-0.012535681,
0.030346118,
-0.0073130233,
0.00806842,
0.042458516,
-0.009728991,
-0.009351293,
-0.02496717,
0.008407047,
-0.0092015155,
-0.013505976,
0.007710258,
0.0024338758,
0.0037672166,
0.014026939,
-0.010367171,
-0.013675289,
0.018793754,
0.032794643,
-0.003545807,
0.012359857,
-0.011220248,
0.0027529658,
0.019718464,
0.0086414805,
-0.017803924,
0.0005787578,
0.02184139,
-0.004314228,
-0.020135235,
0.014235324,
-0.032169487,
-0.00645669,
0.008433095,
0.006766012,
0.0014204392,
-0.040244423,
-0.012900356,
-0.005652453,
0.0044151647,
0.0016117304,
-0.011552363,
-0.022049775,
-0.027585011,
-0.009969937,
-0.008771721,
0.019744512,
0.028236216,
-0.004480285,
-0.040765386,
-0.0022368864,
0.028444601,
-0.02056503,
0.008980107,
0.015550757,
-0.0035685992,
-0.008908474,
-0.015811238,
-0.010113202,
0.015394468,
0.0076256017,
-0.024941122,
-0.009728991,
0.0067855483,
0.012125423,
0.005395227,
-0.027402675,
0.02461552,
0.008791257,
0.008719625,
0.009390365,
0.003233229,
-0.017803924,
0.010849062,
-0.008693577,
-0.006147368,
-0.0291479,
0.014456734,
-0.0013040365,
0.039775554,
-0.010972791,
0.009019178,
-0.00017338313,
-0.03784799,
-0.004577966,
0.004008162,
0.006147368,
-0.006779036,
-0.007130686,
-0.02630865,
-0.014534879,
0.0010590209,
-0.0064176177,
0.0099504,
0.0075930413,
-0.004747279,
0.012516146,
-0.009559678,
0.0016467327,
0.00058852584,
-0.015837288,
-0.01198867,
-0.019106332,
-0.0066878675,
0.023703834,
-0.0022613066,
-0.006443666,
0.0017403433,
0.011793309,
-0.0011933318,
0.008647992,
0.002458296,
-0.024550399,
0.003558831,
-0.0031176403,
0.0044607488,
-0.012320784,
0.009305708,
0.005408251,
-0.012926404,
-0.0054440675,
-0.033497944,
-0.0109988395,
0.009624799,
-0.007866547,
0.005733853,
-0.007033006,
0.04495914,
0.000043167718,
0.018832827,
-0.014586975,
-0.005844558,
0.039645314,
-0.0034188223,
0.021984655,
-0.0019275645,
0.012164495,
0.0016182425,
-0.036363244,
0.017908117,
0.012281712,
0.0062645846,
0.027454771,
-0.00009813851,
-0.01948403,
0.0042719,
-0.030893128,
0.023612665,
-0.027897589,
-0.012294736,
-0.00991784,
0.012919892,
-0.009409901,
-0.016110793,
0.001092395,
-0.004467261,
0.0022303744,
0.0062613287,
-0.0017061551,
-0.035347365,
-0.01613684,
0.0039495537,
-0.006163648,
-0.003868153,
0.025409989,
0.015055842,
-0.008810793,
0.025110435,
0.02333916,
0.026504012,
0.016449418,
0.0029483272,
-0.023352183,
-0.0021326938,
0.025983049,
-0.01096628,
0.00093529205,
0.023951292,
0.0150949145,
0.007566993,
-0.020604102,
0.013519,
0.034748256,
0.0016328946,
0.015641926,
0.0063524973,
-0.010438804,
0.004141659,
-0.022648884,
0.022727028,
0.009800624,
0.0011282114,
0.011995181,
-0.008817305,
0.0000039078614,
0.00091738394,
-0.009058251,
0.0034285903,
-0.02063015,
0.004483541,
0.008315878,
0.040348615,
0.017452274,
0.025097411,
-0.005584076,
-0.007925156,
-0.023443352,
0.019327741,
0.014196252,
0.006284121,
0.005242194,
0.0099438885,
-0.0011892617,
-0.025566278,
0.0056589646,
0.014105083,
-0.03782194,
0.00053154543,
0.017491346,
0.014300445,
0.009038715,
0.017790899,
0.020656198,
0.0006955675,
-0.050976265,
0.04167707,
0.03573809,
-0.020460837,
-0.00080667925,
-0.01814255,
-0.024524352,
-0.0063883136,
-0.0058999103,
0.00615388,
0.031231755,
0.0022531666,
-0.0034220782,
-0.0031257803,
0.01642337,
0.024016412,
-0.019744512,
0.011604459,
-0.0031648525,
-0.005688269,
-0.009969937,
-0.021580908,
0.0035685992,
0.0035816233,
0.021893486,
-0.0038128009,
-0.0021261817,
-0.012327296,
-0.0067204274,
-0.022505619,
-0.006459946,
-0.001076929,
0.006915789,
-0.016175913,
-0.0019568687,
-0.0035979033,
-0.011409098,
0.008726137,
0.008420071,
-0.025423013,
-0.040713288,
-0.014105083,
-0.00647297,
0.021320427,
0.0092926845,
-0.0018038357,
0.01017181,
0.010614629,
0.0019340765,
-0.0085177515,
-0.044985186,
0.018390007,
-0.011584924,
-0.021190185,
0.023716858,
0.0032576493,
-0.019588223,
0.029460479,
0.025097411,
0.017452274,
-0.04339625,
-0.056472432,
0.015928455,
0.0047244867,
0.005414763,
0.033055127,
0.0462355,
0.029095804,
-0.010757894,
0.004770071,
0.033419803,
-0.0010020405,
-0.010009009,
-0.015251203,
0.011643532,
0.01992685,
0.013675289,
0.0013195026,
-0.0140399635,
0.02554023,
-0.00035063276,
0.01319991,
-0.014339517,
0.013532024,
0.027923638,
0.004148171,
-0.010575557,
-0.0018917483,
-0.010686262,
-0.01508189,
0.016840141,
-0.0036565117,
-0.014300445,
0.016175913,
-0.015746119,
-0.0006780664,
-0.01756949,
0.013714361,
0.015133986,
-0.0065739066,
-0.0102239065,
-0.010178322,
-0.01648849,
0.007866547,
-0.010028545,
-0.010074129,
0.0065380903,
0.00247946,
-0.026777517,
0.007671186,
-0.013714361,
-0.004962176,
-0.0075604813,
0.000772898,
-0.021880463,
-0.024876002,
0.00558082,
0.020330597,
0.024693664,
0.007286975,
-0.016462443,
0.013258518,
0.022779124,
0.010080641,
-0.016228009,
0.00765165,
-0.0195752,
0.020317571,
-0.008309366,
0.015160034,
-0.01501677,
-0.03141409,
0.0061929524,
-0.01409206,
-0.008433095,
0.0017989516,
-0.00123159,
-0.014808384,
0.008140053,
0.0014652095,
0.03188296,
0.008967082,
0.00037383192,
0.0023964315,
-0.03573809,
-0.042901333,
-0.020200355,
-0.0111551285,
-0.01572007,
-0.0048742634,
-0.000083079416,
-0.008478679,
-0.02388617,
-0.016983407,
-0.02082551,
0.0033374217,
0.01609777,
0.017165743,
0.015407492,
-0.0030834521,
0.03495664,
-0.0017598794,
-0.006437154,
-0.002624353,
-0.012477073,
0.027090097,
0.013545048,
-0.022492593,
-0.0063818013,
-0.005974799,
-0.0011615856,
-0.01609777,
-0.006466458,
-0.0042914357,
0.037327025,
0.009683407,
-0.043370202,
-0.017230865,
0.0005282894,
0.02917395,
0.004477029,
-0.00583479,
-0.010979303,
-0.019041212,
0.0045421496,
0.006596699,
-0.030294022,
0.020903656,
-0.028079927,
-0.0021180417,
0.014808384,
0.0023736395,
-0.000054334854,
0.0082702935,
-0.002326427,
-0.024511328,
0.008524263,
-0.018168598,
-0.016527563,
0.017947188,
-0.010692773,
0.032820694,
0.028809275,
0.054909542,
-0.009064763,
0.011858429,
0.014626047,
0.020291524,
-0.014365565,
-0.00679206,
0.053971805,
-0.011265833,
-0.007931667,
0.0026731933,
0.0234694,
0.011943085,
-0.024068508,
0.020994823,
0.007085102,
-0.024120605,
-0.025904905,
-0.00953363,
-0.04954362,
-0.038863868,
0.0014326493,
-0.010093666,
0.018129526,
-0.052461013,
-0.007234879,
0.034982692,
0.017126672,
0.020578053,
-0.011207225,
0.022375377,
-0.018324887,
0.03967136,
-0.007104638,
-0.0022580507,
0.0072088307,
-0.019028187,
0.0049654325,
-0.0016060325,
0.018129526,
0.009051739,
0.030893128,
0.0043760925,
-0.023104725,
0.008524263,
0.012561729,
-0.020643175,
-0.01613684,
-0.007703746,
-0.034357537,
-0.014144156,
-0.022596788,
0.00054782553,
-0.029773057,
-0.0076321135,
-0.0001303426,
-0.010015521,
0.025396965,
0.002147346,
-0.014964673,
0.014938625,
-0.0012861283,
0.029278142,
-0.041624974,
0.018455127,
0.022844244,
-0.01294594,
-0.018598393,
0.00011070472,
0.016696876,
0.014118108,
0.04493309,
0.01706155,
0.004174219,
0.0035099909,
-0.0031876448,
0.00029161738,
-0.008713112,
-0.029434431,
0.007508385,
-0.004763559,
0.009266636,
-0.015980551,
-0.0034839427,
-0.048215162,
0.025436036,
-0.022505619,
0.012678946,
-0.0027383137,
-0.009559678,
-0.014000891,
0.027715253,
0.0049556643,
-0.00953363,
0.0064762263,
-0.0014122992,
-0.012906868,
-0.028522745,
0.0029890274,
0.012346832,
0.006889741,
0.037092593,
-0.00400165,
0.013571097,
-0.007443264,
0.004796119,
-0.0066878675,
-0.0033634698,
-0.008224709,
0.040504903,
-0.019327741,
-0.004060258,
-0.0073651196,
0.00052951043,
0.0020903656,
0.016045673,
-0.005369179,
-0.017947188,
-0.023625689,
-0.01699643,
0.005356155,
0.034201246,
-0.030893128,
0.02076039,
-0.03584228,
0.01913238,
-0.03000749,
-0.0066032107,
0.023612665,
-0.020877607,
-0.0021082738,
-0.007697234,
0.019223548,
0.023495449,
0.029981442,
0.019666368,
-0.015407492,
0.03714469,
-0.019366814,
0.028522745,
0.012555217,
0.007996788,
-0.007697234,
0.020018019,
-0.013291079,
-0.021085992,
-0.0025787686,
-0.025227651,
-0.03670187,
-0.012815699,
-0.0027024976,
0.016410347,
0.010367171,
-0.019379837,
0.0022336305,
0.009930865,
0.015251203,
-0.0018217438,
-0.011233273,
-0.0016003344,
-0.052981976,
0.01814255,
0.0047049504,
0.0160066,
-0.0048156553,
-0.01792114,
-0.026673324,
0.012203568,
0.002748082,
-0.009084299,
-0.008869401,
0.011780284,
-0.0085438,
-0.0009084299,
-0.013173861,
-0.011650044,
-0.038994107,
0.0223884,
-0.0094164135,
0.0068246205,
-0.016775021,
0.00768421,
-0.015759142,
0.011890989,
-0.00679206,
-0.0063785454,
-0.011396074,
-0.01970544,
-0.0412603,
0.0117347,
-0.02126833,
0.029356286,
0.017269935,
-0.028340409,
-0.015785191,
-0.020747367,
-0.024823906,
-0.054180194,
0.010816502,
0.013818554,
0.004766815,
0.021567885,
-0.012092862,
-0.0118388925,
-0.0076190894,
0.0063818013,
0.0006455062,
-0.0076125776,
-0.004154683,
-0.0066455393,
0.026217483,
0.028392505,
-0.0059520067,
-0.004340276,
0.030294022,
0.010217395,
-0.02761106,
0.026829613,
-0.012835235,
0.027480818,
-0.020070115,
0.0060236393,
0.015811238,
-0.005864094,
0.029226046,
-0.016332202,
0.013987867,
-0.0022157223,
0.0009849464,
-0.0075930413,
-0.005567796,
-0.017829971,
0.0017777876,
-0.002783898,
-0.00495892,
-0.027011951,
0.010477876,
-0.022740051,
0.01686619,
0.020382693,
0.0001920035,
0.0047179745,
0.0016866189,
-0.018455127,
-0.029278142,
-0.025501158,
-0.01642337,
-0.024928099,
0.013121765,
0.005538492,
-0.011884477,
-0.009273148,
-0.009208028,
-0.018376984,
-0.013206421,
-0.017230865,
-0.022661908,
-0.018168598,
0.007234879,
0.0019291926,
0.011428635,
-0.0099504,
0.008380999,
-0.010510436,
0.0035197588,
0.009579214,
-0.032117393,
-0.015524709,
0.009370829,
0.009448973,
-0.00642413,
-0.004936128,
0.0073651196,
-0.0039560655,
-0.0063687772,
0.008029348,
0.17598143,
-0.01326503,
-0.01166958,
0.022206064,
0.007873059,
-0.0044444688,
0.029043708,
0.0016239405,
-0.011005351,
0.014222301,
0.018871898,
-0.008986618,
-0.009663871,
-0.000059982016,
0.030424261,
-0.030762888,
-0.03810847,
-0.01913238,
-0.017178768,
-0.01893702,
0.025957001,
-0.022180015,
-0.0028832068,
-0.0023899195,
0.010328099,
0.0039951378,
-0.017530417,
0.005567796,
0.0074758246,
0.0102239065,
-0.02496717,
0.0122100795,
0.0075865295,
-0.013069669,
-0.02930419,
0.012555217,
-0.009904817,
-0.008016324,
-0.00899313,
-0.010881622,
0.0045128455,
0.011565387,
-0.020929703,
0.016801069,
-0.0071958066,
-0.0016540587,
0.0048319353,
-0.0036369755,
0.008765209,
-0.011311417,
-0.03414915,
0.01437859,
0.0081465645,
0.033497944,
-0.0055971,
-0.0145999985,
0.0050956733,
-0.0046756463,
0.0146911675,
0.026230507,
-0.015641926,
0.0010093666,
-0.025423013,
0.02369081,
-0.013701337,
0.03453987,
-0.020382693,
0.0011379794,
0.0047993753,
-0.029929345,
-0.007117662,
-0.012900356,
-0.004779839,
0.012157983,
-0.009488045,
-0.015003745,
0.04964781,
0.025800712,
0.0131087415,
0.017178768,
0.0036890719,
-0.0031192682,
-0.031335946,
0.008211685,
-0.0023785233,
-0.04386512,
0.028001782,
0.0109076705,
-0.016371274,
-0.02531882,
-0.0016239405,
-0.018155575,
-0.0026520293,
-0.011135592,
0.00010480318,
-0.007514897,
0.0025722566,
0.009038715,
-0.0028197144,
0.007286975,
-0.0483975,
0.060223367,
-0.008348438,
0.0016597568,
-0.011890989,
0.014456734,
-0.003229973,
0.014430686,
-0.003386262,
0.007091614,
0.011246297,
-0.017517393,
0.016254058,
-0.0023378232,
-0.0020968777,
0.029043708,
0.01116164,
-0.04279714,
0.027350578,
-0.0073065115,
-0.016371274,
-0.01706155,
0.015915431,
0.012568242,
-0.021515789,
-0.002756222,
-0.029199997,
0.0004129042,
-0.010048081,
-0.04068724,
-0.006013871,
-0.02675147,
0.007384656,
0.0028359944,
-0.009221052,
-0.015798215,
0.0035197588,
-0.012672435,
-0.008765209,
0.015160034,
-0.0004456679,
-0.0063883136,
0.0128287235,
-0.0014261373,
-0.004170963,
-0.0028897189,
0.006004103,
0.021476716,
0.0020708295,
0.0003705759,
-0.021125065,
-0.009930865,
-0.00021733942,
0.014704191,
0.036102764,
-0.030997321,
-0.017712755,
-0.029642817,
-0.009807136,
0.0063069128,
-0.02518858,
0.0022482825,
0.009448973,
0.0066878675,
-0.002311775,
0.016149865,
-0.16274896,
0.008530775,
0.0114025865,
-0.045896873,
0.010959767,
0.020747367,
0.013115253,
-0.021685101,
0.0120863505,
0.0057403655,
0.023378232,
-0.0092015155,
-0.026048169,
-0.0127049945,
0.016918287,
0.008823818,
-0.037066545,
0.03597252,
0.026256554,
0.005750133,
0.020304548,
-0.015628902,
0.016410347,
-0.009155932,
-0.0030297276,
0.01486048,
0.024315966,
0.0122100795,
-0.0063818013,
-0.026517035,
-0.014052987,
-0.0007549899,
0.007944692,
0.0033992862,
0.0138836745,
-0.01457395,
-0.0062352805,
-0.00086854363,
0.0028278544,
0.0017712755,
0.022714004,
0.008367974,
0.00991784,
0.003988626,
-0.015576805,
0.019796608,
-0.0022092103,
-0.014990721,
0.029538624,
0.016918287,
0.02056503,
-0.0032022968,
0.03446173,
0.011917037,
0.00620272,
0.0022189785,
0.02388617,
0.0049686884,
-0.0034806866,
0.0018412799,
0.0005140443,
-0.023234967,
0.02653006,
0.01450883,
-0.01609777,
-0.025123458,
-0.0056557087,
0.032534163,
-0.019939873,
0.0020822256,
-0.0050500887,
-0.008563336,
-0.004454237,
-0.027506867,
0.03500874,
0.002932047,
-0.0032853254,
-0.003529527,
-0.005512444,
0.004167707,
-0.03784799,
0.006805084,
-0.04923104,
-0.010927207,
-0.03154433,
0.018689562,
0.008159589,
0.006101784,
-0.020864584,
-0.0024892283,
0.014743264,
-0.025462085,
-0.0003538888,
-0.0058999103,
0.043448348,
0.02917395,
-0.0073195356,
-0.0065641385,
-0.012353344,
-0.009344781,
0.005808742,
-0.03500874,
-0.016345225,
0.0030687999,
0.038811773,
-0.006619491,
-0.012431488,
-0.006889741,
0.043057624,
0.00921454,
-0.0058022295,
-0.0012201939,
-0.0030069356,
0.024485279,
-0.0043598125,
0.027402675,
-0.010158786,
-0.006199464,
0.0027220338,
-0.0056459405,
0.05165352,
-0.0065478585,
0.02184139,
0.021606956,
-0.0022157223,
-0.0041774753,
-0.12367671,
-0.025396965,
0.0073065115,
0.0005543376,
-0.014834432,
0.018220695,
-0.012477073,
0.04253666,
-0.025292773,
0.04295343,
-0.00094506016,
-0.0140399635,
0.0040928186,
-0.016827118,
0.004789607,
-0.0082702935,
-0.0028783227,
0.00896057,
-0.035659943,
0.036493484,
-0.009507582,
0.009318733,
0.015420516,
-0.028679034,
-0.008823818,
0.00073830277,
-0.049413376,
0.03128385,
0.017882068,
0.015212131,
0.004014674,
-0.013831578,
0.0040700263,
0.0023850354,
-0.022088848,
0.0027301738,
0.0144437095,
-0.018298838,
0.023378232,
0.004906824,
-0.013987867,
0.021059945,
0.009312221,
-0.0007281277,
0.009064763,
-0.013740409,
-0.011995181,
0.0075865295,
0.001979661,
-0.018754682,
-0.022206064,
-0.0031160123,
-0.021151114,
-0.0059129344,
0.017816948,
-0.017269935,
0.035529703,
-0.0038062888,
-0.0118388925,
0.008400534,
0.00088563777,
-0.0011127453,
-0.021515789,
0.025292773,
0.02324799,
-0.011539339,
-0.003845361,
-0.016032647,
0.0071111503,
-0.021945583,
-0.01336271,
-0.0019161685,
-0.014665119,
-0.01565495,
-0.019171452,
0.00029609443,
-0.011213737,
-0.008784745,
0.0022775868,
-0.020226404,
0.004737511,
-0.018233718,
0.021307403,
-0.0073195356,
0.017178768,
0.010009009,
-0.010881622,
0.0053105704,
0.003542551,
-0.002302007,
-0.0153033,
0.06006708,
0.0039169933,
-0.005440811,
-0.024797857,
0.020525957,
0.0032706733,
0.0068246205,
0.027246386,
-0.0067855483,
-0.0033178856,
-0.014248349,
-0.05605566,
0.0027057535,
0.0018901203,
-0.008563336,
0.019523103,
-0.000054233104,
0.007996788,
-0.0008156333,
0.00077249104,
0.022453522,
0.006020383,
0.013492951,
-0.018220695,
-0.0042100353,
-0.026204458,
-0.006345985,
0.015889384,
0.005961775,
0.013831578,
0.017608562,
0.01508189,
0.02047386,
-0.012776627,
-0.0041970112,
-0.012607314,
0.0065739066,
-0.016840141,
0.02234933,
-0.015602853,
0.010074129,
0.017882068,
-0.022245137,
-0.0016621988,
-0.00013166535,
-0.02331311,
-0.012711506,
0.010790454,
0.02560535,
0.012477073,
0.034018908,
-0.017973237,
-0.022088848,
-0.00620272,
0.012385905,
0.0062808646,
-0.004467261,
-0.041312397,
0.011780284,
0.008133541,
0.004789607,
0.04925709,
-0.0020333852,
0.017282961,
-0.0041058427,
-0.013909723,
-0.0032609052,
0.0016475467,
-0.0023541034,
-0.017543443,
-0.020174308,
0.011070472,
0.02076039,
0.01329759,
0.0065901866,
-0.002770874,
-0.022232112,
-0.03045031,
-0.0056589646,
-0.039202496,
-0.03328956,
-0.020695271,
-0.015342372,
0.02049991,
0.005854326,
0.004721231,
-0.0038779213,
-0.014534879,
-0.015147011,
-0.0051119532,
0.025136484,
0.01501677,
-0.011832381,
-0.007521409,
0.00495892,
0.031388044,
-0.0051347455,
-0.004021186,
-0.0009556422,
-0.0051835855,
-0.004457493,
0.0025722566,
0.015342372,
0.011728188,
-0.00090191787,
-0.027585011,
0.022844244,
-0.0012690342,
0.01023693,
0.0014440453,
0.020656198,
0.025175555,
-0.0074628005,
-0.011343977,
-0.010738358,
-0.0028555305,
0.01814255,
-0.017660659,
-0.04068724,
-0.00860892,
0.03185691,
0.039749507,
0.025436036,
-0.020109186,
0.0022515387,
0.0020757136,
0.028861372,
-0.011474218,
0.0015832402,
-0.008569848,
0.022648884,
0.009116859,
-0.0033341656,
0.0109988395,
-0.009142907,
0.02490205,
-0.010705798,
0.013278054,
-0.015667973,
0.02930419,
-0.0039104815,
0.007410704,
-0.00054009253,
-0.01613684,
-0.007820963,
0.0041970112,
-0.0068181083,
0.009930865,
0.014417661,
-0.010380195,
0.08001997,
0.01112908,
-0.028418552,
0.01336271,
-0.026855662,
0.025904905,
0.0027887821,
0.014756287,
-0.010705798,
-0.0051738177,
0.014886528,
-0.044333983,
0.03297698,
-0.023899196,
-0.028288312,
0.024315966,
-0.003838849,
0.024797857,
0.00045909898,
-0.026907759,
0.020525957,
-0.031075466,
-0.0048840316,
0.007703746,
-0.036076713,
0.00096134027,
0.038342904,
0.0063752895,
0.0041774753,
-0.0068246205,
0.018090453,
0.00047130906,
-0.022049775,
0.0012511262,
0.0071632466,
-0.024941122,
-0.0012625222,
-0.039879747,
0.023612665,
0.014756287,
-0.018298838,
0.0032022968,
-0.020096162,
-0.026347723,
0.004620294,
-0.0027155217,
-0.019249598,
-0.020695271,
0.01801231
] |
Soil erosion is a major environmental threat to the sustainability and productive capacity of agriculture. During the last 40 years, nearly one-third of the world's arable land has been lost by erosion and continues to be lost at a rate of more than 10 million hectares per year. With the addition of a quarter of a million people each day, the world population's food demand is increasing at a time when per capita food productivity is beginning to decline. | [
0.0011157641,
-0.009600502,
0.021109652,
-0.001180181,
0.0030061214,
0.009110616,
-0.016796106,
0.00620947,
-0.023438204,
-0.021542279,
0.0009050175,
0.020524334,
-0.0028279808,
0.007074724,
-0.0063589807,
0.014314864,
0.037282266,
-0.005166075,
0.013704096,
0.014671145,
-0.016287133,
0.007717302,
0.005261508,
0.0029122795,
0.00015547533,
0.020855166,
0.01853934,
-0.031734463,
0.012177178,
-0.0022887876,
-0.0057895673,
-0.009485983,
-0.0056877728,
0.0058690943,
-0.025601339,
-0.0018052633,
0.0017750431,
-0.007551886,
0.0003851096,
-0.011076524,
0.0061967457,
0.0018545701,
0.0113373725,
0.004125862,
-0.022801988,
0.016439825,
-0.0051692566,
-0.0045839376,
-0.022318464,
0.030869208,
0.033363175,
0.028833317,
-0.029138701,
-0.022992853,
-0.0007022236,
-0.0012278972,
-0.018755652,
0.008576194,
0.02080427,
-0.030614723,
-0.007392832,
0.027891716,
-0.029825814,
0.012660702,
-0.0249015,
0.013589578,
-0.016757933,
-0.0037091402,
0.013475059,
-0.011871793,
0.01551095,
0.014403934,
0.005904086,
0.002221985,
0.0022235755,
0.0025814471,
0.0070683616,
0.0003169152,
0.013360539,
0.019379145,
0.012902464,
-0.024265284,
0.00888794,
0.01206902,
0.017254183,
-0.0033210483,
-0.00250192,
0.008048135,
-0.0007085858,
0.0068202373,
-0.0088306805,
-0.0004417726,
0.015663642,
0.005115178,
-0.012915188,
-0.016643414,
-0.016579794,
0.03819842,
0.022267565,
-0.03539907,
-0.023870831,
-0.004138586,
0.0056082457,
0.0009932925,
-0.046163846,
0.0006588814,
0.010993815,
0.008690713,
0.007869994,
-0.025804928,
-0.024456149,
0.022712918,
0.018793825,
-0.0062380997,
0.00874161,
-0.022331188,
0.04870871,
0.0019849944,
0.0088306805,
-0.007278313,
0.016121717,
0.004129043,
0.014289415,
-0.03931816,
-0.005073824,
-0.004170397,
-0.014454831,
-0.0032017578,
-0.003125412,
-0.01719056,
-0.024379803,
0.03219254,
0.0063589807,
0.0032733323,
-0.02012988,
0.022318464,
-0.03679874,
-0.008455313,
-0.012628891,
-0.016783383,
-0.0010052215,
0.0019929472,
-0.018386647,
-0.020969685,
0.0030427037,
0.02710281,
-0.0014879506,
0.027001014,
-0.00090660807,
0.027179155,
0.019951738,
0.014022204,
0.018857447,
-0.009085167,
0.007965426,
-0.00944781,
-0.0057482133,
-0.009409637,
-0.01133101,
-0.0072719506,
0.01209447,
-0.03181081,
-0.0040813265,
-0.0038459268,
-0.004762078,
0.030767415,
-0.016490724,
0.022598399,
0.022432983,
-0.013958583,
0.008315345,
0.017903123,
-0.0044630566,
-0.0056845914,
0.011909966,
0.021682248,
-0.0053601214,
0.027484538,
-0.003658243,
-0.019315522,
-0.042931866,
0.035628106,
0.007011102,
0.022827435,
-0.016643414,
-0.00090342696,
0.033134136,
0.014632972,
0.007679129,
-0.00314927,
-0.004870235,
0.017903123,
-0.0067629777,
-0.01174455,
-0.6677725,
-0.013933134,
-0.0003407733,
-0.0026116674,
0.0041831215,
-0.000080272584,
0.015269188,
0.007551886,
-0.017661361,
0.0058531887,
-0.003731408,
-0.00030757076,
0.00086684455,
-0.02857883,
0.0036391565,
0.005077005,
-0.023387305,
-0.027993511,
-0.013856788,
-0.0066802697,
-0.022127599,
-0.00007261811,
-0.00803541,
0.0015332809,
0.023170993,
0.0020327107,
0.0051215403,
-0.017699534,
-0.011286475,
0.0052551455,
0.02075337,
0.00859528,
-0.04512045,
0.022649296,
0.049955692,
-0.008016324,
0.0054841833,
0.001095087,
0.0046125674,
0.047843456,
-0.0038300212,
0.012749772,
0.020651577,
-0.0058468264,
-0.00022347092,
-0.0069220318,
0.027230052,
-0.024443425,
0.00054157904,
-0.03511913,
-0.010395772,
0.01730508,
-0.0015030607,
0.01448028,
0.021173274,
0.009072443,
0.009606864,
-0.024481598,
0.014314864,
0.0031985769,
0.005070643,
0.013704096,
-0.008569832,
0.0017257363,
-0.029673122,
0.022903781,
-0.032116193,
0.028069858,
0.017801328,
-0.01380589,
-0.012259886,
0.013436886,
0.026059413,
-0.041023217,
0.017355977,
0.008455313,
0.0013201486,
0.00042745774,
-0.012749772,
-0.0013368492,
-0.008620729,
-0.0066802697,
0.007787286,
0.027484538,
0.013144226,
-0.030283889,
-0.002931366,
0.01212628,
-0.016083544,
-0.01091747,
0.018971967,
0.041481294,
-0.0074946266,
-0.033032343,
-0.008022686,
-0.007596421,
0.0028613822,
0.0066420967,
0.02593217,
0.0070619993,
-0.05435831,
0.008086308,
0.021198723,
0.019697253,
0.012552545,
0.03254882,
-0.025626788,
0.015103772,
0.042524688,
-0.015765436,
0.030716516,
-0.003166766,
-0.040361553,
-0.017063318,
-0.016299859,
-0.0085062105,
0.011929053,
-0.000885931,
-0.0014974938,
-0.016032647,
0.01174455,
0.021007858,
0.019557284,
-0.03234523,
-0.011121059,
0.019353695,
-0.011483702,
0.005808654,
-0.0051787994,
-0.012635253,
-0.0036677863,
0.00031095065,
0.02669563,
-0.02633935,
0.015574572,
0.0058150156,
0.012202626,
-0.019620907,
0.011871793,
0.0028200282,
-0.015256464,
-0.004956124,
-0.0011086067,
-0.001713012,
-0.006724805,
0.013882237,
-0.0029615862,
-0.008525297,
-0.022407534,
-0.02649204,
-0.0067884265,
-0.0106502585,
-0.0071447077,
0.028375242,
-0.002357181,
0.0178904,
-0.01006494,
-0.015358258,
-0.017877674,
-0.025677685,
0.00676934,
-0.0041576726,
-0.035449963,
-0.009377826,
-0.014493004,
0.003938178,
-0.019124659,
0.007361021,
-0.010745691,
-0.03606073,
0.011948139,
-0.0230183,
-0.0009694344,
0.04229565,
0.005509632,
0.020091707,
-0.028146204,
0.0075327996,
0.007131983,
-0.0030999633,
-0.00061712967,
-0.014340312,
-0.017254183,
-0.0023253702,
0.0045044105,
0.023005577,
0.016910626,
0.014912907,
-0.0031063254,
0.0394963,
0.022343911,
0.00888794,
-0.018971967,
-0.018921068,
-0.0050292886,
-0.016338032,
-0.0089515615,
0.019353695,
-0.0024033065,
0.03496644,
0.056852277,
-0.012546183,
0.0026848323,
-0.016643414,
-0.0049497616,
0.00051811856,
-0.008398053,
-0.023807209,
0.032421578,
0.013856788,
0.012934275,
-0.008162653,
-0.018602962,
-0.025155988,
-0.002269701,
0.025474096,
-0.00007222048,
0.0030029402,
-0.01380589,
-0.021631349,
-0.02039709,
-0.015256464,
0.016007198,
-0.019111933,
-0.0022601578,
0.02763723,
-0.018119436,
0.00054396485,
0.0045775753,
-0.042092063,
-0.010752053,
0.0088306805,
0.013385988,
0.011617308,
-0.0046920944,
0.01636348,
0.0040240674,
-0.01797947,
0.03275241,
-0.000058154135,
-0.012278972,
0.00326697,
0.034508366,
-0.005585978,
-0.00029981686,
0.0136404745,
0.0329051,
-0.0058563696,
-0.014136723,
0.025830377,
0.019811772,
0.030691069,
-0.027789922,
-0.01963363,
-0.009676848,
-0.014963804,
0.008938837,
-0.0083853295,
0.032955997,
-0.0038840997,
0.027153706,
0.015256464,
0.012189901,
-0.014671145,
0.008315345,
-0.008188102,
-0.007755475,
-0.009835902,
-0.0012851567,
0.01324602,
-0.01683428,
-0.0050165644,
0.009816815,
-0.016605241,
-0.0071637942,
0.0057323077,
-0.0020724742,
-0.006419421,
-0.0060695023,
-0.018959241,
-0.020053534,
0.0039031862,
0.0070556374,
0.029189598,
-0.0060376916,
-0.014289415,
-0.014862009,
0.002419212,
-0.012317145,
0.017152388,
-0.0001517972,
0.022025803,
-0.004176759,
0.016897902,
0.014594799,
-0.0027564066,
0.0065975618,
0.0033878512,
0.025601339,
-0.004288097,
0.010510291,
-0.022382084,
-0.005344216,
0.009600502,
0.029851263,
0.01804309,
-0.000634228,
0.0069792913,
-0.015001977,
-0.008824319,
-0.00076664047,
-0.012781583,
0.000373777,
0.024990572,
-0.0098422645,
0.023298236,
0.013360539,
0.0009606864,
0.006718443,
-0.0050102025,
0.002249024,
-0.02427801,
-0.0230692,
0.011439167,
0.07095083,
-0.0041131377,
0.00476844,
0.053136773,
0.017877674,
-0.0147729395,
-0.01094928,
-0.035577208,
0.017126938,
-0.0104466695,
0.0063494374,
0.00021313241,
0.023730863,
-0.005983613,
0.018602962,
0.0014831789,
0.007952702,
-0.03064017,
-0.020855166,
0.00036164912,
0.010745691,
-0.00040757598,
0.03522093,
0.03517003,
0.010026767,
0.004727086,
-0.009466897,
-0.0003113483,
0.022674745,
0.013551405,
0.010014042,
0.0131569505,
-0.01719056,
0.007844545,
0.009975869,
0.017661361,
0.037765794,
-0.030691069,
0.020969685,
-0.0030570186,
0.008016324,
0.014938355,
0.0038904618,
-0.0076091453,
-0.010777502,
-0.0067375293,
-0.017814053,
0.044051606,
-0.03817297,
-0.019442767,
0.017534118,
-0.0006604719,
-0.01265434,
-0.0055287187,
-0.010230356,
0.0063080834,
0.041455846,
0.020893339,
-0.039979823,
-0.026797425,
-0.027815372,
-0.003775943,
0.00203112,
-0.007278313,
-0.0042531053,
-0.0015316905,
-0.011133783,
0.003925454,
-0.027306398,
0.027968062,
0.021415036,
-0.026822874,
-0.010510291,
-0.0068965834,
-0.0016700674,
0.0035150943,
0.00050380366,
-0.029774917,
-0.019799046,
0.005745032,
-0.005302862,
-0.016325306,
0.0035119134,
-0.0051692566,
0.0022871972,
0.025003295,
-0.0064798617,
-0.018793825,
-0.006304902,
0.0143275885,
-0.001271637,
-0.0074437293,
0.0023301416,
0.0012430074,
-0.019671803,
-0.0234891,
0.014187621,
0.0178395,
0.012285334,
-0.015027426,
-0.002163135,
0.005904086,
-0.020498885,
0.0026148485,
0.016439825,
-0.0029918065,
-0.00921241,
-0.0253723,
0.0065975618,
0.015663642,
0.0068011507,
-0.009797729,
0.0100013185,
-0.0230692,
0.015180117,
0.024201663,
0.04120136,
0.020626128,
0.02183494,
0.019849945,
-0.006413059,
-0.014353037,
0.0067375293,
0.010942918,
0.018144885,
-0.0019452309,
0.009053356,
-0.036824193,
-0.048301533,
-0.015676366,
-0.025448646,
0.034737404,
-0.0020008998,
-0.0003558834,
-0.02557589,
-0.020906063,
-0.010433945,
-0.004609386,
-0.019799046,
-0.01353868,
-0.026110312,
-0.0051215403,
0.0131951235,
-0.025970344,
0.024965122,
-0.026033966,
-0.007628232,
0.018819274,
-0.014442107,
-0.0036391565,
-0.023120096,
-0.008703438,
0.004688913,
0.020078983,
-0.0064830426,
-0.023679966,
-0.01624896,
-0.005633694,
0.010465756,
0.0131569505,
0.016910626,
-0.018259404,
0.014734766,
-0.006966567,
-0.0021599538,
0.00013628943,
-0.0128324805,
-0.009759556,
-0.021656798,
0.015879955,
0.023336409,
-0.005420562,
0.009632313,
-0.024061695,
0.021974906,
0.01465842,
-0.0068011507,
-0.037434958,
-0.023921728,
-0.0357808,
-0.014187621,
0.009867713,
-0.017572291,
0.02039709,
-0.016770659,
-0.00043461518,
0.0357299,
-0.0026848323,
-0.002716643,
-0.018653858,
0.011795448,
0.022153048,
0.009568691,
0.00013330717,
-0.0070429128,
-0.026721079,
-0.018386647,
-0.02068975,
-0.008932475,
-0.012355318,
-0.016961522,
-0.0041194996,
-0.008983373,
-0.015434604,
-0.021415036,
0.009765918,
-0.0029806728,
-0.014022204,
0.0043739863,
-0.028298896,
0.011922691,
-0.006212651,
-0.002284016,
-0.013258745,
0.020206226,
-0.0022124418,
-0.02707736,
0.018437544,
-0.03537362,
-0.0003558834,
0.014493004,
-0.004450332,
0.023400031,
-0.012488923,
0.007361021,
-0.015650917,
0.013856788,
-0.03142908,
0.04003072,
0.018119436,
-0.011324648,
0.030309338,
-0.029494982,
-0.018615685,
-0.032676063,
-0.018055815,
0.0046221106,
0.002021577,
-0.028986009,
0.019124659,
0.00874161,
-0.025321404,
-0.015180117,
-0.011623669,
0.017139664,
0.01353868,
0.007316486,
-0.013691372,
-0.014047653,
-0.017724982,
-0.0027007377,
0.017508669,
-0.02710281,
0.0145311775,
-0.0026053053,
-0.012342594,
-0.007920891,
-0.029749468,
-0.013118777,
0.029062355,
-0.0023762675,
0.014289415,
-0.020460712,
0.02124962,
-0.01327147,
0.006489405,
-0.0076473183,
-0.0035596294,
-0.0022315283,
0.028553382,
-0.02763723,
-0.026950117,
-0.01268615,
0.0118208965,
0.0123489555,
-0.009625951,
-0.013131502,
-0.026212106,
0.02593217,
-0.01889562,
0.018704755,
0.01086021,
-0.017559566,
-0.0051056347,
-0.010605724,
-0.011808172,
-0.009129702,
-0.009823178,
0.028247997,
0.011305561,
-0.0128324805,
0.02934229,
-0.0049465806,
0.0041099563,
-0.009231497,
-0.007195605,
-0.020346193,
0.018475717,
-0.021033306,
0.005019746,
0.020956961,
0.0054014754,
0.017737707,
0.027713576,
-0.009365102,
-0.01306788,
-0.00214882,
-0.008932475,
-0.032039847,
-0.0011292837,
-0.0029806728,
0.004214932,
-0.011051075,
0.004838424,
0.014200345,
-0.0022235755,
0.027306398,
-0.038122073,
-0.011776362,
0.05005749,
0.0022601578,
-0.020155327,
0.01948094,
-0.014734766,
0.011248302,
-0.018475717,
-0.006998378,
-0.016579794,
0.019709976,
-0.0077745616,
-0.001339235,
0.02501602,
0.010930194,
-0.01777588,
-0.0017018783,
-0.0008246952,
-0.0050102025,
-0.004762078,
-0.01853934,
0.0025400931,
0.0031588133,
0.00072528643,
0.0075073508,
-0.016617967,
0.014811113,
-0.02840069,
-0.0074564535,
-0.009804091,
-0.01842482,
-0.008404416,
-0.0036327944,
0.032676063,
0.0019340971,
-0.0140858255,
-0.014849286,
0.007361021,
-0.037765794,
-0.019888118,
0.007049275,
0.005624151,
0.022700192,
0.027866269,
0.00030160623,
0.026924668,
-0.029164148,
0.033897597,
-0.02987671,
-0.005875456,
-0.02840069,
-0.0049497616,
0.018475717,
-0.005509632,
-0.030283889,
-0.014925632,
0.014683869,
-0.00037616282,
0.009473259,
0.008436226,
0.024392528,
0.0056909537,
-0.008455313,
0.0123489555,
0.015918128,
0.021135101,
0.013487782,
-0.025830377,
-0.009625951,
0.020257123,
-0.013971307,
-0.03499189,
0.0009813635,
0.015256464,
-0.017635912,
0.0035119134,
0.0125907175,
-0.024481598,
-0.0072592264,
-0.027001014,
0.034890093,
0.009352378,
-0.007787286,
0.0035914402,
0.011954502,
-0.020893339,
-0.008633453,
-0.004917951,
-0.0089452,
0.019391868,
0.0022665202,
-0.016668864,
0.018170334,
-0.01551095,
0.011400994,
-0.014747491,
0.014162172,
0.013436886,
-0.02004081,
-0.012202626,
0.02710281,
0.021529555,
-0.007704578,
0.0035659915,
0.00944781,
-0.028069858,
0.0024096686,
-0.021936733,
0.0052964995,
-0.03702778,
-0.0037663998,
0.002221985,
-0.00021869931,
-0.0064353268,
0.0002990216,
-0.0074564535,
-0.036213424,
0.043389942,
0.18170334,
-0.0039063673,
0.0101222,
0.014912907,
0.0145311775,
0.007793648,
-0.013347815,
0.0007841364,
-0.015231015,
0.014620247,
-0.00003770078,
0.007570972,
-0.006142667,
-0.0018243499,
-0.011839983,
-0.023858106,
-0.03064017,
0.010045853,
0.0055987025,
0.036951434,
0.022496603,
-0.017814053,
-0.021351414,
-0.01824668,
0.054002028,
-0.014060377,
-0.018106712,
-0.011210129,
0.020613404,
-0.0136023015,
-0.0075264373,
-0.008474399,
0.0026116674,
0.007634594,
-0.0032510646,
-0.007939978,
0.023679966,
-0.004714362,
0.0049465806,
-0.0027086902,
0.010109475,
0.02295468,
0.028527932,
0.0037504942,
0.021962183,
0.020855166,
-0.005834102,
0.0021551822,
-0.017546842,
-0.00036463139,
-0.018195782,
-0.013754994,
-0.007869994,
0.03595894,
-0.0029504525,
0.0053633023,
0.017915847,
-0.0006215037,
-0.011935416,
0.011833621,
-0.0107711395,
0.031072797,
0.013284193,
0.024786983,
-0.029673122,
0.023807209,
-0.037511304,
-0.006254005,
0.010701156,
-0.006852048,
-0.017139664,
-0.0041194996,
-0.008894302,
0.024176214,
-0.006336713,
-0.010612085,
0.0015038559,
0.038885534,
0.010223994,
0.011636394,
-0.01598175,
-0.0031826713,
-0.027535437,
-0.0040336107,
-0.023005577,
-0.030207545,
0.009975869,
-0.004218113,
-0.019735426,
0.006731167,
-0.016325306,
-0.009059718,
-0.0121453665,
-0.025690408,
-0.009568691,
0.028298896,
0.021974906,
0.0032733323,
-0.02351455,
-0.004809794,
0.006492586,
0.04926858,
-0.0026943756,
0.011483702,
-0.013144226,
0.015663642,
-0.013055156,
0.038249318,
0.006263548,
-0.0037950294,
-0.0031890336,
-0.013424161,
-0.0011563229,
-0.019213729,
-0.0015619107,
0.020422539,
0.010783864,
0.0045107724,
-0.002183812,
-0.01739415,
0.01189088,
-0.016325306,
-0.00026581908,
-0.0065911994,
-0.014340312,
-0.019773599,
-0.027484538,
0.010338513,
-0.02575403,
-0.024290733,
-0.017699534,
-0.02136414,
-0.022445707,
0.009295118,
-0.0145693505,
0.009619588,
-0.009867713,
-0.017699534,
-0.003072924,
0.010777502,
-0.012189901,
-0.019086486,
-0.015396431,
-0.0030999633,
-0.000101893995,
0.009288756,
0.013029707,
0.0060535967,
-0.0027182335,
-0.012387129,
-0.024087144,
0.01465842,
-0.011407356,
-0.0060854075,
0.0026943756,
-0.015765436,
-0.03781669,
-0.009575053,
0.008938837,
0.00794634,
-0.028909663,
0.028171651,
0.008633453,
-0.006972929,
-0.013029707,
0.024914226,
-0.15869775,
0.015638193,
0.018704755,
-0.025664961,
0.011101972,
0.008773421,
0.012310782,
0.01250801,
-0.005633694,
-0.009587778,
0.020562507,
0.010809313,
-0.017495945,
-0.019722702,
0.0064035156,
0.040361553,
0.0033337728,
0.011814535,
0.014543901,
0.01495108,
0.0070174644,
0.00032526552,
0.0154600525,
-0.034533814,
0.012927912,
0.02122417,
-0.0019563646,
0.026848322,
0.020982409,
0.0046666455,
-0.03410119,
0.0058945427,
0.015447329,
-0.01353868,
-0.008881577,
-0.023272788,
-0.01174455,
-0.043746226,
-0.0036677863,
0.027153706,
0.0044535133,
0.016897902,
0.0053760265,
0.013691372,
-0.00064854283,
0.024328906,
0.012100832,
-0.0063144453,
0.019939015,
-0.014314864,
0.0055700727,
0.024468875,
-0.016910626,
0.02425256,
0.0031651754,
0.030920105,
0.00029424997,
0.033515867,
-0.0018036729,
0.0050515565,
-0.03382125,
-0.0028677443,
0.024290733,
0.0068965834,
-0.029291393,
-0.016936075,
0.0013718411,
0.015854508,
-0.015650917,
0.011439167,
0.010230356,
-0.005379208,
-0.0043739863,
0.00042666247,
-0.009575053,
-0.014416658,
-0.013385988,
0.00032665723,
-0.008041772,
-0.0045362213,
-0.0113373725,
0.007927254,
-0.0032176634,
0.008926113,
-0.017915847,
-0.010796588,
-0.0031079159,
-0.0028120754,
-0.007965426,
-0.0025051013,
0.041354053,
-0.024990572,
-0.0035596294,
-0.01306788,
-0.004046335,
-0.0075009884,
0.016528895,
0.012915188,
0.015803609,
0.008684351,
0.014276691,
-0.013742269,
-0.014429383,
0.013665923,
0.026084863,
0.019290075,
-0.007583697,
-0.008983373,
0.026644733,
0.0060026995,
-0.016210789,
-0.014989253,
0.016350755,
-0.0075646103,
0.008391691,
-0.0023492281,
0.04188847,
-0.018704755,
0.00070381415,
-0.0076473183,
0.022751091,
0.0012899283,
-0.042473793,
-0.009670486,
0.0043453565,
-0.008824319,
-0.12133915,
0.01568909,
-0.00066524354,
0.029418636,
0.0004294459,
0.007316486,
0.0020406633,
0.011502788,
-0.002917051,
0.016236236,
-0.023883555,
-0.024290733,
-0.0030442944,
-0.024430702,
0.028807867,
-0.011661842,
-0.015269188,
0.0030983728,
-0.020333469,
0.02669563,
0.014353037,
-0.018030366,
0.018552063,
-0.006966567,
-0.023031026,
0.021911284,
-0.021211447,
0.010548464,
-0.0043040025,
-0.0027261863,
0.022432983,
-0.017355977,
0.008079945,
-0.018997414,
0.018183058,
0.014238518,
-0.010612085,
-0.0143275885,
-0.0041035945,
-0.018653858,
-0.0045362213,
0.016007198,
0.0143275885,
-0.014213069,
0.012565269,
-0.026822874,
0.021936733,
0.018373923,
-0.008258086,
-0.017788604,
-0.044051606,
-0.042422894,
-0.014963804,
0.008188102,
0.011884518,
-0.010281254,
0.0063589807,
0.0117000155,
0.004876597,
0.029011458,
-0.014416658,
0.0038904618,
-0.042015716,
0.025079641,
0.02360362,
-0.028858766,
-0.016007198,
-0.008569832,
-0.0052106106,
-0.028807867,
-0.02651749,
0.012698875,
-0.0011022445,
0.024443425,
-0.029265944,
0.016058097,
-0.024468875,
-0.007889081,
0.01692335,
0.0032860565,
-0.000537205,
-0.019531837,
0.011311923,
-0.01551095,
0.019709976,
-0.005967708,
-0.016605241,
0.013373264,
0.003422843,
-0.016198063,
0.0070174644,
0.02210215,
0.016261686,
0.00041354052,
0.015676366,
0.040870525,
-0.010828399,
-0.014798388,
0.014365761,
-0.009428724,
-0.018183058,
-0.0039540837,
-0.033235934,
0.0076600425,
0.0072528645,
-0.0016557525,
0.0047493535,
0.003969989,
0.018857447,
0.0014505729,
-0.0022649295,
0.011852707,
0.009727745,
0.009244221,
0.0035214564,
-0.008410778,
-0.029393187,
-0.0127115995,
0.035017338,
0.025028745,
0.025766755,
-0.00620947,
-0.009097891,
0.008251724,
-0.009008821,
0.0076600425,
-0.014060377,
0.007424643,
-0.0021504106,
0.010758416,
-0.0007193219,
-0.020537058,
0.01362775,
-0.015320085,
-0.011191042,
-0.0042690104,
-0.015879955,
-0.0122280745,
0.0024208026,
0.024099868,
0.02021895,
0.043898914,
-0.015103772,
-0.020333469,
0.016108993,
-0.023145543,
-0.021122377,
0.014543901,
-0.004046335,
-0.018297577,
0.016681587,
0.014823836,
0.056292407,
0.02633935,
0.016528895,
0.010033129,
0.009441448,
-0.051838893,
0.032828756,
0.014518453,
-0.0043485374,
-0.040107068,
0.011051075,
0.022712918,
0.038096625,
0.0038427457,
-0.022165772,
-0.000047865327,
-0.004838424,
-0.018577512,
-0.009441448,
-0.010567551,
-0.0069920155,
-0.0027436821,
0.010561189,
0.013691372,
0.018272128,
-0.0105293775,
-0.019417318,
0.020702474,
0.0039604455,
0.003941359,
0.0042403806,
0.0054046563,
-0.021173274,
0.04120136,
-0.0043040025,
-0.0017543661,
-0.009657761,
-0.01180181,
-0.0067757023,
-0.0005618584,
-0.023120096,
0.015752712,
-0.006384429,
0.008340794,
-0.0050674616,
-0.0015340763,
-0.002710281,
-0.0074055563,
0.00018032752,
0.022140322,
0.007131983,
0.008423502,
-0.008531659,
-0.02598307,
-0.02189856,
0.010586637,
-0.012673426,
-0.019226452,
-0.023756312,
0.025766755,
-0.019340971,
0.029774917,
0.009390551,
0.001892743,
-0.008315345,
0.003772762,
-0.01957001,
0.00014454036,
-0.017292356,
0.026975565,
0.0033274107,
0.0028152566,
0.0051469887,
0.0062730913,
0.005118359,
0.006972929,
-0.011318286,
-0.0054523726,
0.016681587,
-0.014912907,
0.016528895,
-0.01671976,
-0.019251902,
-0.022611123,
-0.008398053,
-0.0068965834,
0.024952399,
0.03275241,
-0.01795402,
0.036620602,
0.014365761,
0.012768858,
0.027993511,
0.03438112,
0.038834635,
0.023832658,
0.01839937,
-0.0022617485,
-0.018284854,
-0.004730267,
-0.005659143,
0.0049370374,
-0.010739329,
-0.0063176267,
0.02413804,
0.0012438026,
0.02745909,
-0.0149765285,
0.022254841,
0.013500507,
-0.025066918,
0.022712918,
0.012838842,
-0.01562547,
-0.018768378,
0.012800669,
0.00835988,
0.0033274107,
-0.032981448,
-0.019926291,
0.011235578,
-0.0022060797,
-0.000462052,
0.011490064,
0.013131502,
-0.012304421,
-0.011025626,
0.018742928,
0.0014839742,
0.013487782,
0.011063799,
-0.0102876155,
-0.0310219,
-0.03852925,
0.0022649295,
0.00550327,
-0.008099032,
-0.015549123
] |
IMPORTANCE Among nontraditional cardiovascular risk factors, recent influenzalike infection is associated with fatal and nonfatal atherothrombotic events. OBJECTIVES To determine if influenza vaccination is associated with prevention of cardiovascular events. DATA SOURCES AND STUDY SELECTION A systematic review and meta-analysis of MEDLINE (1946-August 2013), EMBASE (1947-August 2013), and the Cochrane Library Central Register of Controlled Trials (inception-August 2013) for randomized clinical trials (RCTs) comparing influenza vaccine vs placebo or control in patients at high risk of cardiovascular disease, reporting | [
-0.034977578,
-0.011961176,
-0.0014434487,
-0.030355915,
-0.022583121,
0.004421434,
-0.016097039,
-0.009624085,
-0.021375187,
0.001185778,
-0.005104179,
0.011022401,
-0.016215205,
0.013904375,
0.016333373,
0.0021598393,
0.059608936,
-0.012079344,
0.01930069,
-0.016136428,
-0.008002565,
0.03818123,
-0.014377045,
-0.01061538,
-0.008547449,
0.023226477,
0.0000814453,
-0.036579404,
-0.012315678,
-0.017541308,
0.01608391,
0.011560719,
-0.021808468,
-0.0038043368,
-0.015742537,
-0.037866116,
-0.0022533885,
-0.014665899,
0.0066830283,
-0.007254171,
0.029358057,
0.022911364,
-0.006056084,
0.006545166,
0.004434563,
-0.0032085758,
0.016464671,
-0.0064105866,
-0.020561144,
0.026495777,
0.034321092,
-0.008862562,
0.00987355,
-0.007398598,
0.0041850987,
-0.019615803,
-0.0062497472,
-0.005196087,
0.0039389166,
-0.03437361,
-0.008580273,
-0.011383468,
-0.017265584,
-0.007950046,
0.0021516331,
0.020482365,
-0.014048802,
0.030093322,
0.0073329494,
0.019353209,
0.0145608615,
0.03952046,
-0.0009970382,
0.034321092,
0.00803539,
-0.010543167,
-0.018906798,
-0.017016118,
0.006912798,
0.009059507,
-0.0058788327,
0.0041916636,
0.0033201782,
0.019169394,
0.010759806,
0.007096614,
0.021335797,
0.0192613,
-0.008652487,
-0.003636933,
0.010346221,
0.0042770067,
0.0046282266,
0.03434735,
-0.008225771,
-0.0043886094,
-0.010352786,
0.011134004,
0.02451319,
-0.010260877,
0.008810043,
-0.011541025,
-0.011875833,
-0.0033907506,
-0.025839292,
0.0069456226,
-0.0054324223,
-0.009906375,
0.01738375,
0.005278148,
-0.013398881,
0.041122288,
-0.014508342,
-0.021532742,
0.009151416,
-0.009689734,
0.0022681593,
-0.005438987,
-0.0018266725,
-0.017725123,
0.014495213,
0.013576132,
0.028570274,
-0.0005370877,
0.028176382,
-0.011265301,
-0.023672888,
0.0028409434,
-0.008961035,
-0.0065911203,
0.009893245,
0.014088191,
-0.00602326,
0.0013942122,
-0.012919646,
0.027546156,
-0.050050497,
-0.0056654746,
-0.021900374,
-0.036947034,
-0.006200511,
0.015059791,
-0.013110027,
-0.013346362,
0.007195087,
0.007483941,
0.0545146,
0.020101603,
0.026009979,
-0.002143427,
0.01225003,
-0.02547166,
0.00066469214,
-0.018775502,
-0.007890963,
0.005727841,
-0.031301256,
0.024723265,
0.016701005,
-0.019917788,
-0.016779784,
-0.01414071,
-0.0011422858,
0.013412011,
0.006141427,
0.0021910223,
0.0050319657,
-0.01415384,
-0.003692734,
-0.0018808326,
-0.031327516,
0.028386457,
-0.030697288,
0.017764512,
0.025340362,
-0.0011234118,
-0.012519189,
0.0012932776,
-0.016766654,
-0.0329556,
-0.020692442,
0.0033907506,
0.036684442,
-0.0047628065,
-0.022254879,
-0.0020465953,
0.027441118,
-0.02637761,
-0.0019497636,
-0.007996,
-0.023817314,
0.012427282,
-0.0024207924,
-0.015348644,
-0.6524946,
-0.022504343,
0.023856703,
0.0032397588,
0.031695146,
0.01554559,
0.012578273,
0.003333308,
-0.002478235,
0.051704843,
-0.02028542,
0.026810892,
0.012158122,
-0.009939199,
-0.01460025,
-0.030697288,
0.016911082,
-0.012072779,
0.007871268,
-0.009998282,
-0.011252171,
0.03592292,
-0.002594761,
0.009236759,
-0.009164546,
0.008803478,
0.01976023,
-0.03248293,
-0.013050943,
0.01839474,
-0.0027703713,
0.023384035,
0.0096766045,
0.019957177,
0.044168383,
-0.008862562,
-0.0052059344,
0.022871975,
-0.0081732515,
0.019668322,
-0.03915283,
-0.013254453,
0.017304974,
0.018263442,
0.0041850987,
0.02404052,
-0.0059674582,
0.015703147,
0.00081404275,
-0.02027229,
-0.0076218033,
0.009906375,
-0.018841151,
0.0024437695,
-0.000995397,
-0.017213065,
0.0109961415,
-0.015637498,
-0.0031593393,
0.023305256,
-0.0118692685,
0.0025438836,
-0.008652487,
-0.012742395,
0.0064368458,
0.012985295,
0.0007754742,
0.028491495,
0.0039389166,
-0.017987719,
0.01412758,
0.014652769,
0.00918424,
-0.0086130975,
0.041516177,
0.011035531,
0.02409304,
0.023843573,
-0.03917909,
0.00602326,
-0.009131721,
0.0039651757,
-0.016110169,
0.0047398293,
0.006413869,
0.003607391,
-0.03106492,
0.0076086735,
0.0028048367,
-0.014495213,
-0.0029016684,
0.007897528,
-0.030618511,
-0.033743385,
-0.023882963,
0.010306831,
0.00011375673,
0.0024240748,
0.014337656,
0.0011537743,
-0.004972882,
0.0029886528,
0.0039717406,
0.0031018967,
0.010214923,
0.010884539,
-0.015414293,
-0.001041351,
0.041621216,
-0.037813596,
-0.0007775257,
-0.0022139992,
0.0046019675,
-0.0007373159,
0.017974589,
-0.028964166,
0.0063350904,
-0.0007689093,
0.022871975,
-0.017134286,
0.018105885,
-0.013405446,
-0.0020383892,
0.002852432,
-0.0012186023,
0.0064269984,
-0.013136286,
-0.0068537146,
0.011166828,
-0.030040802,
0.030565992,
-0.009761948,
0.033244453,
-0.0013720558,
0.015269866,
0.0017331232,
0.0008837944,
0.006147992,
-0.013970024,
-0.016149558,
-0.014665899,
0.005698299,
0.0030264007,
0.008403022,
-0.015624369,
-0.008947905,
0.00683402,
0.012597968,
-0.008002565,
0.009965459,
0.0074117277,
-0.03334949,
-0.0037058638,
0.008317678,
0.0041621216,
-0.0010380686,
-0.015151698,
-0.025235325,
-0.000073034076,
-0.015886962,
0.022320526,
-0.0013884681,
-0.004986012,
0.005501353,
0.01457399,
-0.019497637,
-0.006827455,
-0.019681452,
0.010937058,
-0.036132995,
0.015703147,
-0.022963883,
0.020035954,
0.039021533,
0.0024289985,
0.03453117,
-0.015637498,
0.007162263,
-0.019103745,
-0.007201652,
0.0029033097,
-0.030671028,
-0.020863127,
0.020849997,
0.0077596656,
0.011153698,
0.02162465,
0.0028951035,
-0.0124994945,
0.017265584,
-0.00530769,
0.01270957,
-0.008160122,
0.0047989134,
-0.006397457,
-0.009190805,
-0.021112593,
0.010812325,
-0.0031314385,
0.008961035,
0.03195774,
-0.010917364,
0.01461338,
0.0004435384,
0.0053963154,
-0.018092755,
0.0012374762,
-0.0063810446,
0.019576415,
0.017265584,
0.016582837,
-0.0061906637,
-0.00991294,
-0.019208783,
0.0019694583,
-0.012611098,
0.0060757785,
-0.009420576,
-0.007936916,
0.006213641,
-0.009591262,
-0.01081889,
0.03689452,
-0.008160122,
-0.003439987,
-0.007930351,
0.0035122004,
0.0054061627,
0.010937058,
-0.021782208,
-0.01737062,
0.015138569,
0.020482365,
0.011416293,
0.0008091191,
0.023370905,
-0.02028542,
-0.013293843,
0.02450006,
0.027152264,
0.011593544,
-0.0071885227,
0.002517624,
0.015650628,
0.018263442,
-0.011580414,
0.021060074,
0.018578555,
0.001185778,
0.019064356,
0.0026784632,
-0.008343938,
0.0025422424,
-0.007398598,
-0.010424999,
-0.031773925,
-0.006568143,
-0.006925928,
0.04088595,
0.022780066,
0.020403586,
-0.0035680018,
-0.007214782,
0.0060199774,
0.015690017,
0.005189522,
-0.02354159,
-0.0047562416,
-0.004309831,
0.020088473,
-0.026600815,
-0.0044805175,
0.0034793762,
-0.019537026,
0.007864703,
0.014272007,
0.01654345,
-0.0010397098,
0.004513342,
0.009702864,
-0.003149492,
-0.045061205,
0.0024043801,
0.02212358,
-0.003134721,
-0.0021401446,
0.0053208196,
0.018591685,
-0.0029574698,
0.039336644,
0.0046479213,
0.007963176,
-0.0013753383,
-0.007405163,
0.011829879,
-0.01654345,
0.031248737,
-0.011344079,
-0.0026259443,
-0.024605097,
-0.014954752,
-0.015663758,
-0.013274148,
-0.0067683714,
0.008462106,
0.01085828,
0.013050943,
0.0040997555,
-0.0024962884,
0.018053368,
0.036526885,
-0.016464671,
-0.0072213467,
-0.026193794,
0.008790349,
0.043853268,
-0.011271866,
0.008087909,
0.0048711267,
-0.009361492,
0.0027276997,
-0.026193794,
-0.00459212,
-0.022977013,
0.048658747,
-0.010247747,
-0.013484224,
0.02162465,
0.0005223167,
0.007083485,
0.000021207577,
-0.017226195,
0.0080485195,
-0.0052223466,
0.0099260695,
0.008311113,
0.01844726,
0.0056326506,
0.015388033,
0.028964166,
0.0077005816,
-0.019970307,
0.0071360036,
-0.010070496,
0.0056031086,
-0.016884822,
0.0154405525,
0.030487213,
0.040465802,
-0.024670746,
0.015703147,
0.029305538,
0.0003651704,
-0.006269442,
-0.003981588,
0.01977336,
-0.017633216,
0.01415384,
-0.018355351,
-0.013169111,
0.0036664747,
0.010063931,
0.011107745,
0.019878399,
0.03445239,
0.013576132,
0.0032052933,
0.012604533,
-0.005301125,
-0.027546156,
0.009328667,
0.011009271,
0.014928494,
-0.032929342,
0.018013978,
0.014941623,
-0.0038929624,
-0.03999313,
0.006788066,
-0.012295984,
-0.008770654,
-0.0010167328,
-0.029358057,
-0.0011463888,
-0.025865551,
-0.020206641,
0.0066567687,
0.010523472,
-0.031406295,
-0.00085917616,
-0.033585828,
0.0027703713,
-0.0022156404,
-0.0021516331,
0.020666182,
-0.0034662464,
-0.030329656,
0.009171111,
0.0077005816,
0.004815325,
0.013733689,
-0.012387892,
0.0054422696,
0.009085767,
-0.013201935,
0.00077178143,
-0.0014418075,
-0.03214156,
0.0012916364,
-0.011560719,
-0.03159011,
-0.0027818598,
0.008573708,
0.01177736,
0.015335514,
-0.0038535732,
0.00085261127,
-0.005796772,
0.005813184,
0.045481354,
0.006141427,
0.01931382,
-0.010267442,
-0.008317678,
0.002158198,
-0.039231606,
-0.0061742514,
-0.021099463,
-0.019865269,
-0.018985577,
-0.004638074,
0.008179816,
0.01177736,
-0.02074496,
0.008389892,
-0.01604452,
-0.0062431823,
0.012716135,
0.040150687,
0.023410294,
0.0050319657,
0.019064356,
0.016241465,
-0.015296126,
-0.0015985436,
0.03860138,
0.0016576273,
0.017764512,
0.0016658334,
0.0066337916,
0.02029855,
-0.0071360036,
-0.045875248,
0.0043656323,
0.010713853,
0.040334504,
0.00376823,
-0.0059970003,
-0.052151255,
-0.018302832,
-0.005560437,
-0.0026751808,
-0.008626227,
-0.03019836,
0.007746536,
-0.0024191511,
0.008081344,
-0.020613663,
0.04561265,
-0.031380035,
0.013379186,
-0.002668616,
-0.01742314,
-0.005593261,
-0.005209217,
-0.00082963426,
-0.016766654,
-0.006794631,
-0.025826162,
-0.015151698,
-0.0026718983,
-0.022018543,
0.031274997,
0.007825314,
0.034111015,
-0.027441118,
-0.014272007,
0.002990294,
0.008521189,
0.011560719,
0.00825203,
0.010024542,
0.014193228,
0.03537147,
0.01322163,
0.0015690017,
-0.006643639,
-0.012814608,
0.010792631,
-0.021874117,
0.0070506604,
-0.019379469,
-0.009821031,
0.0010216564,
-0.0041621216,
-0.0017823597,
-0.004431281,
0.005544025,
-0.043721974,
0.007871268,
0.019983437,
-0.009952329,
0.015401163,
-0.01111431,
-0.005507918,
-0.03450491,
0.011409728,
-0.0008160942,
0.02170343,
-0.0029180807,
-0.013799338,
-0.01603139,
-0.004746394,
0.025012119,
0.005911657,
0.004582273,
0.016661616,
0.015414293,
-0.019011836,
0.024618227,
-0.030959884,
0.018355351,
-0.0021860986,
-0.019038096,
0.0061118854,
-0.03479376,
-0.013707429,
-0.014902234,
-0.00013447707,
-0.006545166,
-0.00825203,
0.012381327,
-0.011291561,
-0.0038174666,
-0.020403586,
-0.019970307,
0.011980871,
-0.00028823843,
0.027992565,
0.020692442,
-0.013825596,
-0.021007555,
0.0014959676,
0.009433704,
0.0020154123,
0.012420717,
0.023331515,
-0.020429846,
-0.005993718,
0.00991294,
0.014928494,
-0.037813596,
-0.018197794,
0.04382701,
0.017711993,
0.011541025,
-0.01058912,
-0.029568132,
-0.022018543,
0.03300812,
0.0013170752,
-0.0084227165,
0.016753525,
-0.036159255,
-0.006991577,
0.0075627198,
0.00067782187,
0.01928756,
0.0058460087,
-0.011816749,
0.0197471,
-0.015624369,
0.0068668444,
-0.013011554,
-0.00009944738,
0.022071062,
0.004096473,
-0.00052272703,
0.0058099017,
0.009282713,
0.0001347848,
0.032876823,
-0.03206278,
0.036369327,
-0.006728982,
0.010031107,
0.00918424,
-0.017620087,
-0.0078056194,
-0.0047923485,
-0.01364178,
-0.02263564,
-0.014482083,
-0.0062037935,
0.025852421,
-0.009775078,
-0.0025209065,
-0.0067618066,
-0.012131862,
0.001907092,
0.0109961415,
-0.025524179,
-0.0082389,
-0.027677452,
0.0048087602,
-0.010123015,
-0.019694582,
0.00064253574,
0.012230336,
0.009532178,
-0.008796914,
-0.020561144,
-0.033244453,
0.003088767,
0.016569708,
0.010287137,
-0.016162688,
-0.008357068,
-0.023226477,
-0.017318103,
0.012945905,
0.030014543,
-0.013169111,
-0.017291844,
0.0022008696,
0.012565143,
-0.0034728113,
-0.014902234,
0.030802326,
-0.020442976,
-0.025721123,
0.013917505,
-0.021926634,
0.033953458,
-0.02736234,
0.0148759745,
0.021755949,
-0.015913222,
0.012190946,
-0.008429281,
0.03203652,
0.0060265423,
-0.020390457,
-0.010267442,
-0.008606533,
0.014035672,
0.002410945,
-0.01741001,
0.0008969241,
-0.005209217,
-0.005163263,
0.0024158687,
-0.012131862,
-0.016425282,
0.009072637,
-0.020469235,
-0.0023223194,
0.0078056194,
-0.019445118,
-0.0058985273,
0.014823455,
0.009374621,
-0.002821249,
0.006269442,
-0.014547732,
0.025655476,
0.010746677,
-0.010096756,
-0.020692442,
-0.018841151,
-0.05322789,
0.0053208196,
-0.025642347,
0.013083767,
0.00016955804,
0.00031716484,
0.01746253,
0.015650628,
-0.014994142,
0.008435846,
-0.0066567687,
-0.004194946,
0.017016118,
-0.007890963,
0.010536602,
0.0045494484,
-0.021099463,
-0.008534319,
0.030565992,
-0.008626227,
-0.011849574,
0.010031107,
-0.014442693,
-0.007175393,
-0.029909505,
0.006377762,
0.0024815174,
0.000657717,
-0.00011037172,
-0.024618227,
-0.020508625,
0.009387751,
-0.0029853703,
-0.00011262839,
-0.01362865,
-0.011882398,
0.01057599,
-0.0025356775,
-0.031458814,
-0.033953458,
0.017725123,
-0.020075344,
-0.006551731,
-0.005514483,
0.010221488,
0.01836848,
-0.0197471,
0.0012801478,
-0.0011045379,
-0.003128156,
0.0075102006,
0.0104906475,
0.015860703,
0.0062530297,
-0.02778249,
-0.011823314,
0.022898234,
0.019720841,
-0.0020006413,
-0.00072008313,
0.00028249418,
-0.022517473,
0.00919737,
-0.011554155,
-0.016976729,
-0.00010437103,
-0.0146265095,
-0.0025291126,
-0.028806608,
-0.014193228,
0.004936775,
0.013970024,
0.002624303,
0.02119137,
-0.010871409,
0.00542914,
0.010405304,
-0.012099038,
-0.0034596815,
0.0059608934,
0.1799297,
0.0013564643,
-0.011560719,
0.00471357,
-0.013444834,
0.011783925,
0.02922676,
0.0003032145,
-0.02123076,
0.00080624694,
0.024710136,
0.010746677,
0.0030099887,
-0.0059149396,
0.0054061627,
0.007733406,
-0.005337232,
-0.022254879,
0.011895528,
-0.0221761,
-0.010621944,
0.017094897,
0.01366804,
-0.007070355,
0.021427706,
0.011573849,
-0.0128736915,
0.030723548,
0.015913222,
-0.0018398023,
-0.022950754,
0.0019579697,
0.010326526,
0.012230336,
-0.00895447,
-0.019051226,
-0.014639639,
0.00010760217,
0.0072804308,
0.0024651051,
-0.02598372,
0.006886539,
-0.007851574,
-0.0011972665,
0.013799338,
0.03064477,
-0.0009789849,
-0.009328667,
-0.026259443,
-0.0036697572,
-0.03201026,
-0.018145274,
-0.019156264,
-0.013103462,
-0.0044641052,
0.003142927,
0.032587968,
-0.0033743384,
-0.0059773056,
-0.0034367046,
0.012867127,
0.0009059508,
-0.01746253,
0.0134382695,
-0.022806326,
0.028150123,
-0.0036106734,
0.005711429,
-0.029962024,
0.0013933916,
0.00800913,
-0.0020531602,
-0.04563891,
0.014272007,
-0.01600513,
-0.018512907,
0.021755949,
0.03910031,
0.00401113,
0.008770654,
-0.01600513,
0.0033447966,
-0.01651719,
0.0022451824,
-0.008041955,
-0.026915928,
0.006230053,
-0.002814684,
-0.029541872,
0.021506485,
0.005849291,
0.012821173,
-0.0174494,
-0.0039159395,
0.034216054,
0.0040931907,
-0.0023173958,
-0.013970024,
0.010621944,
0.0015271507,
-0.020219771,
0.09206561,
0.006666616,
-0.008166687,
0.0008969241,
0.0022714417,
-0.024578838,
-0.014731548,
0.0133726215,
-0.0050450955,
-0.0025964023,
-0.011797055,
0.00034486034,
-0.008875691,
-0.00588868,
0.0009896527,
0.03676322,
-0.037813596,
0.02972569,
-0.025300974,
0.007582414,
-0.013996283,
0.019169394,
0.04432594,
0.020009695,
-0.018224053,
-0.022845715,
0.009171111,
-0.01927443,
-0.010661334,
0.013602392,
-0.0045560133,
-0.007982871,
-0.007096614,
0.0076940167,
0.01461338,
0.033638347,
-0.012361633,
-0.0093024075,
0.017029248,
-0.016464671,
-0.012486365,
0.014770936,
-0.016359633,
-0.003988153,
-0.012565143,
0.018302832,
0.008376762,
-0.019707711,
0.0010068855,
0.002563578,
-0.003998,
0.00035799007,
0.0016806043,
0.03815497,
-0.02214984,
0.00253896,
-0.04708318,
-0.008514624,
0.007109744,
-0.01507292,
0.0007898348,
0.017186806,
-0.013234759,
0.0028721266,
-0.007897528,
-0.1649093,
0.016280854,
0.00989981,
0.003814184,
0.037025813,
-0.005169828,
0.027519897,
-0.00182339,
0.0046708984,
-0.0044509755,
0.035949178,
0.011488507,
0.0061611217,
-0.014915364,
0.023410294,
-0.009637215,
-0.013261018,
0.034058496,
0.03106492,
0.018000849,
0.04466731,
-0.030277139,
0.013878115,
-0.020442976,
-0.009906375,
-0.008140427,
-0.015401163,
0.01839474,
-0.024618227,
-0.0013769795,
-0.035240173,
0.009079202,
0.05083828,
0.015479942,
0.0029049509,
-0.0025061355,
-0.010569425,
-0.027178524,
0.0013269224,
0.019917788,
0.05892619,
0.016766654,
0.00023530923,
-0.011042096,
-0.024303114,
0.010398739,
-0.009092332,
-0.027126005,
0.019733971,
0.0011595185,
0.006164404,
-0.009256453,
-0.003988153,
0.0039159395,
0.002456899,
0.018604815,
-0.019208783,
-0.00020689568,
0.013602392,
-0.025025249,
-0.0069587524,
-0.009794773,
-0.0041818162,
-0.016202075,
0.01932695,
-0.042671595,
-0.00826516,
-0.00048210696,
-0.0047398293,
0.014324526,
-0.015335514,
-0.005337232,
-0.00518624,
0.010103321,
0.03812871,
0.007588979,
-0.0032758655,
0.026285702,
0.0019251454,
0.008842868,
0.0077071465,
0.0029328514,
-0.018814892,
-0.016701005,
0.029016685,
0.024591967,
0.018132145,
-0.0041752513,
0.011527895,
-0.021073204,
0.0154405525,
-0.032666747,
0.0020876257,
-0.020928776,
-0.00018925262,
0.01603139,
0.017856421,
-0.006292419,
0.018053368,
0.0059838705,
-0.007477376,
-0.016307114,
-0.0013909299,
-0.016648486,
0.011501636,
-0.0221761,
-0.019090615,
0.010786066,
0.034977578,
-0.028990425,
-0.0070375307,
0.010786066,
0.014114451,
0.016897952,
-0.022583121,
0.009446834,
-0.04204137,
-0.011948046,
-0.018709853,
-0.023922352,
0.04469357,
0.015151698,
0.0007635754,
0.030592252,
-0.023003273,
-0.019694582,
-0.12404961,
-0.018893668,
0.008842868,
-0.014468953,
-0.02170343,
0.020902516,
-0.011987436,
0.0080485195,
0.008324243,
0.01927443,
-0.013878115,
-0.0042146407,
-0.023318386,
-0.0047496767,
0.052545145,
-0.0006039672,
0.0039060921,
-0.04233022,
-0.011094615,
0.029489355,
0.0013146134,
-0.0069587524,
0.012420717,
-0.0035253302,
-0.0019054508,
-0.023239607,
-0.004907233,
0.019458247,
-0.0053339493,
0.023777926,
0.006377762,
0.0216903,
0.013320102,
0.00007329052,
-0.042724114,
0.0025209065,
-0.018709853,
-0.027992565,
0.015742537,
-0.0063416553,
0.02969943,
0.017239325,
0.022806326,
-0.013970024,
0.007273866,
-0.0050910497,
-0.02170343,
0.007996,
-0.0008345579,
-0.0075298953,
0.013510483,
-0.03673696,
-0.018486647,
-0.0043656323,
0.025300974,
-0.016399022,
0.013563002,
0.01176423,
-0.0020154123,
-0.01654345,
-0.008383327,
-0.009775078,
-0.037524745,
0.015388033,
0.011206217,
-0.035266433,
0.0071425685,
-0.024434412,
0.012361633,
-0.038758937,
-0.022832585,
-0.013694299,
-0.01927443,
0.0035056355,
-0.04091221,
0.0041227327,
-0.01508605,
-0.00027018506,
0.013720559,
-0.023922352,
-0.023751667,
-0.022688158,
0.0059444816,
-0.0004640536,
0.010648204,
0.044010825,
0.0013794414,
0.0016953753,
-0.025038378,
-0.008160122,
-0.00047143907,
0.035660323,
0.00048210696,
-0.0059608934,
0.010274007,
0.035108875,
-0.006367915,
-0.02453945,
0.014915364,
0.033848424,
-0.01650406,
0.0106810285,
-0.057823293,
0.016635356,
0.008580273,
-0.009775078,
0.0014065214,
-0.009164546,
0.030303396,
0.0005305228,
0.011219347,
0.006292419,
-0.03770856,
0.01342514,
-0.017068638,
0.013759948,
-0.0052354764,
-0.0027703713,
0.037367187,
0.017304974,
0.041621216,
0.022084191,
-0.00041256048,
0.00015930044,
-0.011134004,
0.024775784,
0.021440836,
0.015479942,
0.020442976,
0.008199511,
-0.02221549,
0.0020859845,
0.016753525,
0.008291419,
0.007910657,
-0.00364678,
-0.003738688,
-0.041673735,
-0.0052124993,
0.023265867,
0.0106810285,
0.04049206,
-0.0060265423,
-0.011107745,
0.006223488,
-0.034688722,
0.0010241183,
0.0078581385,
-0.03857512,
0.034583688,
-0.0068668444,
-0.01107492,
0.0011496713,
-0.007201652,
-0.024697006,
-0.028438976,
-0.0038995272,
0.033191934,
0.037734818,
-0.004972882,
-0.007346079,
-0.014075061,
0.019642062,
0.009880115,
-0.017646346,
0.0052157817,
0.027677452,
-0.020928776,
-0.02121763,
0.027493637,
0.006919363,
-0.024224335,
-0.03298186,
-0.010103321,
-0.013412011,
0.012453541,
0.0012916364,
0.011692017,
0.014902234,
0.02594433,
-0.0076218033,
0.0017019401,
0.009400881,
0.0014130863,
-0.02547166,
0.036080476,
0.0127227,
0.009821031,
-0.016149558,
0.019431988,
-0.015059791,
0.0095518725,
-0.022543732,
0.009807901,
-0.0050155534,
0.0022074345,
0.010937058,
0.027020967,
0.006893104,
-0.004434563,
0.016622227,
0.016569708,
0.0164778,
0.018788632,
-0.0045494484,
-0.041699994,
0.0075627198,
0.015296126,
-0.012473235,
-0.03245667,
-0.02263564,
0.011311255,
0.019733971,
0.033244453,
-0.0033776208,
-0.0063252435,
-0.011284996,
-0.012755524,
-0.019996565,
0.015873833,
-0.021887247,
0.018893668,
-0.012584838,
0.00015981332,
-0.0075692846,
-0.01649093,
0.00682089,
0.021545872,
0.016727265,
-0.023961741,
0.023620369,
0.010556296,
0.0074708117,
0.009578132,
-0.031143699,
-0.007543025,
0.007162263,
-0.031353775,
-0.0043525025,
0.01179049,
0.018197794,
0.054409567,
-0.0038535732,
-0.011422858,
-0.016766654,
-0.013851856,
0.013136286,
0.012387892,
0.00021869192,
-0.001449193,
-0.022871975,
0.012387892,
0.00176923,
0.013930635,
-0.06128954,
-0.03390094,
0.012794914,
0.0011193088,
0.017725123,
-0.018814892,
-0.008829738,
-0.00707692,
-0.0077202762,
0.020088473,
-0.011435987,
-0.028045084,
-0.009696299,
0.018210923,
-0.031485073,
-0.025143417,
-0.010031107,
-0.010208358,
0.007667757,
-0.0070506604,
-0.0028639205,
0.03201026,
0.0050024237,
-0.0039618933,
-0.03214156,
0.010405304,
-0.0018857563,
-0.00776623,
0.009952329,
-0.02587868,
-0.038076192,
0.0029541873,
-0.010667899,
-0.022386175,
0.0035876965,
-0.02359411
] |
The "ba, ba, ba" sound universal to babies' babbling around 7 months captures scientific attention because it provides insights into the mechanisms underlying language acquisition and vestiges of its evolutionary origins. Yet the prevailing mystery is what is the biological basis of babbling, with one hypothesis being that it is a non-linguistic motoric activity driven largely by the baby's emerging control over the mouth and jaw, and another being that it is a linguistic activity reflecting the babies' early sensitivity to specific phonetic-syllabic patterns. Two groups of hearing babies were studied over time (ages 6, 10, and 12 | [
-0.023856059,
-0.0012773299,
0.022624291,
-0.022096392,
-0.019645426,
0.004103795,
-0.019620288,
0.0016355478,
-0.017546395,
-0.007648268,
-0.006432212,
0.021769596,
-0.017571533,
-0.013964216,
0.004663118,
-0.005898027,
0.037279807,
0.014102476,
0.0120411515,
-0.0020738936,
-0.017169325,
-0.000054351327,
-0.017445844,
-0.028129537,
-0.024723323,
-0.0060457136,
0.013298056,
-0.023340728,
-0.00576291,
-0.00018372417,
0.006246818,
0.008672645,
-0.0135242995,
0.006218538,
-0.020902332,
-0.01642775,
-0.0005879959,
-0.03335826,
0.018124571,
-0.0055523785,
0.011004204,
0.03639997,
0.00022310067,
-0.026344731,
-0.02026131,
0.0087417755,
-0.0012301959,
-0.0010479447,
-0.01602554,
0.014027061,
0.012946122,
0.018853577,
-0.034212958,
0.031975668,
-0.0011932743,
-0.0007761389,
-0.00447144,
0.0323276,
0.013951647,
-0.04067345,
-0.0069632544,
-0.0002910521,
0.0040943683,
0.0056937803,
-0.018061727,
-0.00076356984,
0.003824134,
0.03217677,
-0.0054675373,
0.030014895,
0.00010860446,
-0.006347371,
-0.00120113,
0.0024651051,
0.035017375,
0.00062688143,
-0.009898128,
-0.017508687,
-0.016339766,
0.022360342,
0.0020408996,
0.0043331804,
-0.01564847,
0.03459003,
-0.0045374273,
-0.0051470264,
0.018199986,
0.015661038,
-0.02227236,
0.01869018,
0.001937205,
0.0070386687,
0.02729998,
-0.009187977,
0.0015860571,
0.024471942,
-0.009634178,
0.011946883,
-0.021845011,
-0.015686177,
-0.031347215,
-0.007566569,
-0.0096656,
0.0024965277,
-0.0022388622,
0.002714915,
-0.0016418323,
-0.0076356987,
0.0014328718,
-0.036500525,
-0.034916826,
0.041000243,
0.009495919,
-0.026445284,
0.01191546,
0.011230447,
0.0043865987,
0.0069444007,
-0.010872229,
0.013549437,
0.030769037,
0.0051470264,
0.0025279503,
-0.009187977,
0.017483551,
-0.00048155178,
-0.04017069,
-0.01906725,
-0.019544875,
-0.013348333,
-0.012374231,
-0.0016952507,
0.00887375,
0.040044997,
-0.032503568,
0.041754387,
-0.0070763757,
-0.023617247,
0.011865185,
-0.013008968,
0.02621904,
0.0064793457,
-0.026118489,
0.0014077338,
0.00440231,
0.018049158,
0.03418782,
0.033760473,
-0.008634938,
0.006372509,
0.007604276,
-0.014554962,
0.008848612,
0.0064133583,
0.016540872,
0.03911489,
0.02330302,
0.032151632,
-0.024006888,
-0.013976785,
-0.013159797,
-0.007070091,
0.02621904,
0.0053858384,
0.0059137386,
0.0064353542,
-0.0026630678,
-0.009634178,
0.0095273405,
-0.022498602,
-0.024635341,
0.002870457,
0.002905022,
-0.010620848,
-0.025490036,
-0.0053889807,
0.016729407,
0.0027761892,
-0.024522219,
-0.021028023,
-0.014869188,
-0.0020016213,
0.020588106,
0.009439358,
-0.015371949,
0.0019670564,
-0.00040849418,
-0.01684253,
0.02795357,
-0.008936595,
0.010300337,
-0.004006385,
0.007246058,
0.0020330441,
-0.6596238,
0.0049427794,
0.013310625,
-0.0017612383,
-0.005184734,
0.017470982,
-0.0013032535,
0.0035004807,
0.009056001,
0.033710197,
0.0026599255,
-0.013172366,
0.0046474067,
-0.010092949,
-0.014781204,
-0.006400789,
-0.0049522063,
-0.019230649,
0.008264151,
0.0026379295,
-0.018740455,
0.028783128,
-0.013838526,
0.0074471626,
-0.0033433677,
0.00552724,
0.026872631,
-0.003491054,
0.0037707153,
0.01762181,
-0.005904312,
-0.003123409,
0.02303907,
0.00463798,
0.043388363,
0.010746539,
-0.0073340414,
0.03574638,
-0.02464791,
0.023805782,
-0.014492116,
-0.0024965277,
0.023114486,
0.021744458,
-0.02187015,
0.007975063,
0.011016773,
0.00847154,
0.0024431094,
-0.034791134,
-0.0026410718,
0.009778722,
0.02662125,
-0.00003844362,
0.0122171175,
-0.007271196,
0.02742567,
-0.016113523,
-0.012933554,
-0.015120569,
0.008465256,
-0.014152751,
0.013046675,
0.0074911546,
-0.01760924,
0.02119142,
-0.013976785,
-0.0034282086,
0.016804822,
-0.008785767,
0.0067244424,
0.016528303,
0.0019529164,
-0.015158276,
0.011909176,
-0.013562006,
0.008930311,
0.009175408,
0.014982309,
0.004842227,
-0.004389741,
0.017068772,
-0.032151632,
-0.008226444,
0.044293337,
-0.031623732,
-0.009043433,
0.017031064,
0.0016716839,
-0.01657858,
0.011035627,
0.014680652,
-0.00847154,
-0.035168204,
-0.01145669,
0.024270838,
-0.005524098,
-0.0038838368,
0.018401092,
-0.0040975106,
-0.0072272043,
0.0098478515,
0.014655514,
0.0018335104,
0.034087267,
0.00007178107,
-0.018250262,
0.009923266,
0.030241137,
-0.027450807,
0.014203028,
-0.009181692,
0.027978707,
0.0056152237,
0.0036387404,
-0.021618769,
0.01656601,
-0.013813388,
0.025628295,
-0.037732292,
-0.0067998567,
-0.015824435,
0.011909176,
-0.0237178,
0.0082767205,
0.008188737,
0.0044682976,
0.027802741,
-0.0035916064,
-0.008251582,
0.0011783486,
0.0050150515,
-0.0018146568,
-0.012946122,
0.026269317,
0.026445284,
0.009910697,
0.003431351,
0.0018822154,
-0.017986313,
-0.049044438,
0.0057252026,
-0.005140742,
0.0073026186,
-0.0071203676,
-0.014957171,
-0.011023058,
-0.0020126193,
0.00038178492,
0.016188938,
0.022033546,
-0.0021728748,
-0.007459732,
-0.003087273,
-0.015799297,
0.003156403,
-0.012795294,
-0.026017936,
-0.014077337,
0.0000107831165,
-0.006969539,
0.021266835,
-0.004615984,
0.017923467,
0.000022425445,
-0.017005926,
-0.022486033,
-0.002678779,
-0.011682933,
-0.025515174,
-0.0066050366,
-0.009332521,
-0.003205108,
0.0025986515,
-0.008339565,
0.00240226,
-0.009313667,
-0.00334651,
-0.009087424,
-0.020085344,
-0.0051564532,
-0.022498602,
-0.0036544516,
-0.0060362867,
0.035595555,
0.0063662245,
0.049220406,
-0.004006385,
-0.017998882,
0.03114611,
0.012958691,
0.035143066,
-0.022222083,
0.017533826,
-0.0073717483,
-0.01787319,
-0.009627894,
-0.00080284814,
0.0040943683,
0.028280364,
0.020537829,
0.028380917,
0.029914342,
0.006611321,
0.0048956457,
-0.011758347,
0.004889361,
-0.025464898,
0.005476964,
0.0074157403,
-0.008037908,
-0.011739494,
0.025326638,
-0.0048108045,
-0.0038178493,
0.030266276,
-0.0036607361,
0.0048233736,
-0.010652271,
-0.004433733,
0.017785208,
-0.008936595,
0.01119274,
0.02210896,
-0.030115446,
0.012895847,
-0.009495919,
0.023391005,
0.011029342,
-0.019117527,
0.009426788,
0.011324715,
0.0092948135,
0.003993816,
-0.012946122,
-0.0020141904,
0.0034722004,
-0.016126093,
0.0024619629,
0.021731889,
-0.00032934843,
0.010363183,
-0.0009348232,
-0.018451367,
0.0333834,
-0.0012749732,
-0.007547715,
-0.000017306995,
-0.028305503,
-0.011821193,
-0.020814348,
-0.004496578,
-0.041000243,
-0.0025970803,
-0.0008122749,
0.0011162888,
0.012958691,
-0.014756066,
-0.0062593874,
0.028431194,
0.019456891,
0.010419743,
0.010740254,
0.010777961,
0.011972021,
0.00456885,
-0.009131416,
0.0027416244,
-0.0011194311,
-0.044871513,
-0.03267953,
-0.032956053,
0.009653031,
-0.022548879,
0.026646389,
-0.0059954375,
-0.0118526155,
0.0166917,
-0.0007215421,
0.0073654642,
-0.007629414,
-0.037279807,
-0.0028673147,
-0.0070952293,
-0.0025122392,
-0.000072222945,
0.0033810749,
0.009747299,
-0.017848052,
-0.029109923,
-0.02823009,
0.009615324,
-0.0100363875,
-0.0056120814,
-0.007843088,
0.008622369,
0.01224854,
0.013838526,
0.00033504376,
0.00009343322,
-0.014529823,
0.014190459,
-0.023252744,
-0.029311027,
0.007616845,
-0.005432972,
-0.013813388,
-0.008955449,
0.009558763,
-0.019570014,
-0.000021603057,
0.019004405,
-0.011538389,
0.007861941,
0.029864065,
0.029084785,
0.0069318316,
0.018036589,
0.03629942,
0.018828439,
-0.011161317,
-0.02253631,
0.006938116,
0.023340728,
0.07315188,
-0.014567531,
0.018174848,
0.03682732,
-0.0027086306,
0.010639702,
-0.041075658,
-0.025351776,
0.031724285,
0.013398608,
-0.026822355,
-0.010080379,
0.021807304,
0.0067872875,
0.0025263792,
-0.00007075001,
0.0049207835,
-0.02649556,
0.003886979,
-0.006278241,
-0.009653031,
0.0023488414,
0.02729998,
0.020537829,
-0.0012144846,
-0.013499161,
-0.00019157983,
0.019368907,
0.012085143,
-0.046455212,
0.012707311,
-0.0009835282,
0.004163498,
0.026948046,
0.017709794,
0.00920683,
0.04625411,
0.014416702,
0.006812426,
0.00987299,
0.007861941,
0.016653992,
0.00016742368,
-0.0082767205,
0.010476304,
-0.011890323,
0.0070952293,
0.009477065,
0.0013912369,
-0.0051250304,
0.020537829,
-0.009024579,
-0.007805381,
-0.0011579238,
0.031849977,
0.01012437,
-0.01403963,
0.0006425927,
0.008169883,
-0.037983675,
0.00301343,
-0.016176369,
0.015208552,
-0.012443361,
-0.005178449,
-0.024258269,
-0.034263235,
-0.020877194,
-0.036249142,
0.0018209413,
-0.017043633,
-0.009866705,
-0.016993357,
-0.021505646,
0.026017936,
0.013071814,
0.0080881845,
-0.007962494,
-0.011085903,
0.03984389,
-0.0011320001,
-0.028833404,
-0.01641518,
-0.0021320253,
0.01760924,
0.01377568,
-0.0013016823,
-0.0038649833,
-0.0005491104,
0.0034407778,
0.02399432,
0.018338246,
0.022083823,
-0.019406615,
-0.0013142515,
0.0077865273,
0.017295014,
0.02953727,
0.006183973,
-0.016201507,
-0.012839286,
-0.01709391,
-0.00301343,
-0.013197504,
0.011764632,
-0.0028798839,
0.002977294,
0.024321115,
-0.021480508,
-0.010891083,
0.009558763,
-0.02755136,
0.0021304542,
0.0024336826,
0.015673608,
0.0015436366,
-0.0049207835,
0.01245593,
-0.0017156755,
-0.021731889,
0.020449847,
-0.021392526,
0.02145537,
0.027098874,
-0.013461454,
0.016930511,
0.019570014,
-0.002952156,
-0.038059086,
-0.0090182945,
0.003118696,
0.03604804,
0.014479547,
-0.03856185,
-0.020789212,
-0.01013694,
-0.0034816272,
0.0057911905,
-0.03745577,
-0.011871469,
0.022360342,
0.025251225,
-0.0018303681,
-0.014831481,
0.017156756,
-0.016088385,
0.004389741,
0.015183414,
-0.019909376,
0.024962137,
-0.026973184,
0.053694986,
-0.011230447,
-0.02106573,
-0.0005821042,
-0.0296881,
0.02492443,
0.0014352285,
0.032428153,
0.010715116,
0.013172366,
-0.010495158,
0.014215597,
0.031347215,
0.016113523,
-0.013825957,
-0.011481828,
0.008930311,
-0.0077299667,
0.0055932277,
0.0040975106,
0.012355377,
-0.008370988,
0.0072020665,
0.026344731,
0.013285487,
0.0053135664,
-0.012543913,
-0.023642385,
0.0011728496,
-0.0065798983,
-0.0036261713,
0.0034250664,
0.010388321,
-0.010891083,
0.0003095129,
0.0098478515,
-0.015434795,
0.00801277,
-0.021291973,
0.0075854226,
-0.017119048,
0.0016795394,
-0.018928992,
0.0061305547,
-0.015057723,
-0.010872229,
-0.02290081,
-0.033961575,
-0.0064290697,
0.015120569,
0.008924026,
0.014504685,
-0.023441281,
-0.015045154,
-0.0020660379,
-0.01403963,
0.0043865987,
-0.018099435,
0.010507727,
-0.024308546,
-0.028305503,
-0.033307984,
0.0027903293,
-0.00787451,
0.020902332,
-0.012807863,
0.024157716,
0.0017109622,
-0.018174848,
0.014504685,
-0.006287668,
0.033307984,
-0.008666361,
0.014027061,
0.0023064208,
0.018061727,
-0.014152751,
-0.0060582827,
0.014919464,
-0.009351374,
0.027677052,
-0.0060645672,
-0.0020063347,
-0.00078399456,
0.011381276,
0.033081744,
-0.031347215,
-0.045525104,
0.013398608,
0.0036607361,
-0.021631338,
0.01105448,
-0.009489634,
0.00423577,
0.020726366,
-0.0036167444,
0.0030212856,
-0.014316149,
-0.009546194,
-0.010369468,
0.024371391,
0.006517053,
0.0022027262,
0.008465256,
-0.0021430233,
0.011990875,
-0.009627894,
-0.011921745,
0.0052915704,
-0.009653031,
0.017043633,
-0.01173321,
0.010325476,
0.0076356987,
-0.01212285,
0.0023849774,
0.014906894,
0.001960772,
0.03019086,
-0.005008767,
-0.028255228,
0.008986872,
0.035042513,
-0.022310065,
0.0038586988,
-0.015283966,
-0.03790826,
-0.012814147,
-0.004700825,
0.0177475,
0.017672086,
-0.003418782,
-0.0035476147,
-0.0029694384,
0.007126652,
-0.01085966,
-0.018476505,
0.008949164,
-0.0087417755,
-0.013486592,
-0.0019827678,
0.0050747544,
0.007641983,
-0.008452687,
-0.0214428,
0.00063866493,
0.02346642,
-0.011946883,
0.020374432,
-0.007629414,
-0.0036324558,
0.010438597,
0.0019497741,
-0.0032836646,
-0.008440118,
0.03247843,
-0.005392123,
-0.007616845,
0.014894325,
0.005084181,
0.020047637,
-0.01026263,
-0.023529263,
0.017370429,
-0.0036827321,
-0.00085312437,
0.0063787936,
-0.017420705,
0.024044596,
0.020437278,
-0.006517053,
0.023893766,
-0.009376512,
0.015560485,
0.024836445,
0.015170845,
-0.019595152,
-0.026344731,
0.026068212,
-0.017898329,
-0.004474582,
-0.021530785,
-0.009508487,
-0.021467939,
-0.016767114,
-0.020072775,
0.014253304,
-0.03202594,
-0.0010448024,
-0.0010730828,
0.018501643,
0.0071894974,
0.018250262,
0.013474023,
0.0075288615,
0.013788249,
-0.0055995123,
-0.022888243,
-0.00064691337,
-0.02305164,
0.042206872,
0.007975063,
-0.0071580745,
-0.008377273,
0.014064768,
-0.02609335,
0.012732449,
0.015510209,
0.007516293,
0.006473061,
-0.0039749625,
-0.017106479,
-0.0073340414,
-0.010030103,
0.017282445,
-0.030140584,
-0.017433275,
0.03388616,
-0.0051595955,
-0.0060582827,
0.013675128,
-0.010840807,
-0.0012034867,
0.03205108,
-0.03486655,
0.006994677,
0.026520697,
-0.003051137,
-0.014718359,
-0.0051375995,
0.010645987,
-0.004257766,
0.013197504,
0.008817189,
-0.0053009973,
-0.0077551045,
-0.00000767154,
-0.0030197145,
-0.05590714,
0.004308042,
-0.008773197,
0.0065421914,
0.026948046,
-0.025075257,
-0.024786169,
0.02835578,
-0.015937557,
0.02702346,
0.0060331444,
-0.025452329,
-0.0062593874,
0.004672545,
-0.014693221,
-0.020085344,
0.007849373,
-0.019934515,
0.010118086,
-0.00083505636,
-0.033433676,
-0.025364345,
-0.010759108,
0.005275859,
-0.035997763,
-0.0058886004,
-0.014441839,
-0.003469058,
-0.024999842,
0.032629255,
0.0038115648,
-0.03893892,
0.00016290668,
-0.0065484755,
-0.026973184,
-0.014668083,
-0.01641518,
-0.020072775,
-0.02357954,
0.025062688,
0.013448885,
-0.0005585372,
0.013197504,
0.010294053,
0.014027061,
-0.037028424,
-0.011682933,
0.17214572,
-0.04474582,
-0.0059702992,
0.0022687137,
0.004710252,
-0.029512132,
0.0021618768,
0.0027651913,
-0.026193902,
-0.021153713,
0.0063410862,
0.018715316,
-0.03893892,
0.011155033,
0.0242457,
-0.029813789,
-0.0017109622,
-0.01934377,
-0.018451367,
-0.013360902,
0.00033406183,
-0.019268356,
-0.035293896,
0.00012048614,
0.029059647,
0.009954688,
-0.023881197,
0.008163598,
0.0004190993,
0.022171807,
-0.015950127,
0.00003940103,
-0.011330999,
0.02848147,
-0.013788249,
-0.00894288,
0.009841567,
-0.01403963,
0.004672545,
0.018966699,
-0.0041886363,
0.013888801,
0.00046662602,
0.00023193828,
0.009357658,
0.02755136,
0.012525059,
-0.02253631,
-0.0023331302,
0.0098478515,
-0.010847091,
0.00887375,
0.01417789,
0.02373037,
0.005473822,
-0.0019214937,
-0.017936036,
0.031598594,
0.0054895333,
0.023277882,
-0.0312718,
0.028858542,
-0.02621904,
0.018790731,
0.0051941606,
0.028003845,
0.017005926,
0.0013291772,
-0.0016544014,
-0.03788312,
-0.0047636703,
-0.015007447,
-0.04120135,
0.02714915,
-0.025087826,
-0.024786169,
0.037832845,
0.00729005,
0.018614765,
0.02807926,
-0.003349652,
0.0065924674,
-0.026973184,
-0.025640864,
-0.015862143,
-0.020299017,
0.014215597,
0.010570572,
0.019142665,
-0.017445844,
0.005524098,
-0.020349294,
-0.014554962,
-0.00729005,
0.012016013,
-0.014429271,
-0.009979826,
0.022611722,
0.000113808834,
0.0035381878,
0.0068564173,
0.02041214,
0.05444913,
0.014253304,
0.01191546,
-0.027626775,
0.00223572,
0.013285487,
-0.007070091,
-0.026948046,
0.0021116007,
-0.008484109,
0.020311587,
-0.00005061989,
-0.002273427,
-0.0002380264,
-0.017898329,
-0.006680451,
0.030517656,
0.006661597,
-0.0009403221,
-0.01391394,
0.010111801,
0.030391965,
0.0066741663,
-0.002020475,
-0.020575536,
0.018426228,
0.022234652,
-0.016088385,
-0.03509279,
-0.013901371,
0.0098038595,
-0.014228166,
-0.0015672036,
-0.014529823,
0.012757587,
-0.008697784,
-0.0156359,
0.006001722,
0.0003686267,
-0.0115760965,
0.01033176,
0.023617247,
0.007893364,
-0.038511574,
0.026822355,
0.021970702,
-0.023441281,
-0.012481068,
-0.018979268,
-0.008427549,
0.014592668,
-0.021983271,
-0.0008381986,
-0.015937557,
-0.019155234,
-0.010941359,
-0.0010667982,
0.00973473,
-0.032076217,
-0.00034270305,
0.014668083,
0.003107698,
-0.01615123,
-0.022712275,
-0.1546496,
-0.0047573857,
0.0024132577,
-0.02528893,
0.022863105,
0.0024902432,
0.0317997,
-0.010847091,
-0.010250061,
-0.013838526,
0.028380917,
-0.009822713,
-0.021895288,
-0.014001923,
-0.012443361,
-0.028204951,
-0.013360902,
0.022775121,
0.021669045,
-0.005131315,
-0.0032490997,
-0.026596112,
0.029210474,
-0.005238152,
-0.0012545484,
0.012060004,
-0.0029317313,
0.010608279,
-0.0052664327,
-0.02503755,
-0.017584102,
0.0013260349,
-0.0029270179,
-0.018514212,
0.016100954,
0.009118847,
-0.0007513936,
-0.016540872,
0.006994677,
0.0030087167,
-0.0013315339,
0.02134225,
0.005536667,
-0.0077990964,
0.002199584,
0.01921808,
0.030291414,
-0.0069758235,
0.027073737,
-0.032227047,
0.005712634,
-0.025314068,
0.006133697,
-0.012242256,
-0.00056010834,
0.0017910898,
0.0042012054,
0.04575135,
0.009935835,
-0.008810905,
-0.00787451,
-0.0030668485,
0.0323276,
-0.016540872,
0.014454409,
-0.00540155,
-0.0094833495,
0.024220562,
-0.04462013,
-0.008672645,
-0.01191546,
-0.019620288,
0.01026263,
-0.025490036,
-0.009722161,
0.013046675,
-0.0080881845,
-0.017961174,
0.030668486,
0.0029977188,
-0.006718158,
0.0074094557,
-0.039919306,
0.004813947,
-0.0019057824,
0.005750341,
-0.008515532,
0.015120569,
-0.008760628,
-0.019582583,
0.01907982,
-0.017106479,
-0.002917591,
0.008496678,
0.012971261,
0.0052287253,
0.00420749,
-0.010180932,
0.011085903,
-0.009565048,
-0.0037015856,
-0.010388321,
-0.011079619,
0.03283036,
0.048240017,
-0.00014218739,
-0.021254266,
0.0029914342,
0.027878156,
-0.003478485,
-0.016616285,
0.006743296,
0.026746942,
0.039190304,
-0.025653433,
0.03604804,
-0.023642385,
-0.010023818,
0.02742567,
0.013184935,
0.03745577,
-0.0077990964,
-0.017307583,
-0.0077551045,
0.0027306264,
-0.01974598,
-0.14348829,
-0.019670565,
0.0032710957,
-0.020437278,
-0.018061727,
0.016126093,
0.004421164,
0.022008408,
-0.011092188,
0.034640305,
-0.02795357,
-0.0138008185,
-0.0003505587,
-0.009112562,
0.026269317,
0.004543712,
0.014529823,
-0.016352335,
-0.032578982,
0.018765593,
-0.0013865235,
-0.013360902,
-0.006397647,
0.01535938,
-0.008521817,
-0.012851855,
-0.032754947,
0.011035627,
0.012745018,
-0.00073214725,
0.003015001,
-0.025125533,
0.009590186,
-0.0221341,
0.0071706437,
-0.013562006,
0.0043865987,
-0.0068815555,
0.027928432,
-0.011594949,
-0.011909176,
0.019796256,
0.028054122,
-0.0074911546,
0.01574902,
-0.02621904,
-0.016553441,
0.018086866,
-0.007434594,
-0.02833064,
-0.03645025,
-0.015296536,
-0.018174848,
-0.036676493,
0.039542235,
-0.005093608,
0.006755865,
0.011142464,
-0.0036827321,
0.007246058,
0.016767114,
0.003968678,
-0.045851897,
0.004615984,
-0.0025609443,
-0.019771118,
-0.011085903,
-0.017169325,
0.015786728,
-0.019406615,
-0.004308042,
0.021141144,
0.035696104,
0.02383092,
-0.027325118,
0.0007828162,
-0.009979826,
-0.0012435506,
-0.0023928331,
-0.004339465,
-0.014089907,
-0.02928589,
0.008458971,
-0.017307583,
0.0065296222,
-0.00021367388,
0.00092382525,
-0.0065484755,
0.00669302,
-0.017558964,
-0.0037455773,
0.037405495,
-0.016038109,
-0.015485071,
-0.005643504,
0.023604678,
-0.023240175,
-0.021631338,
0.019670565,
0.015459933,
-0.016377473,
-0.004006385,
-0.027325118,
0.01907982,
0.025402052,
-0.021040592,
0.00894288,
-0.013448885,
0.035444725,
-0.03934113,
-0.014693221,
0.015799297,
-0.0123176705,
0.018602196,
-0.016038109,
-0.020110482,
-0.032754947,
-0.019507168,
0.018476505,
-0.013210073,
0.016930511,
-0.0014187316,
0.022310065,
-0.0124056535,
0.030844452,
0.0062216804,
-0.019293495,
-0.003937255,
-0.020474985,
0.011412699,
0.004751101,
-0.0026096492,
-0.0010958641,
-0.030593071,
0.03406213,
0.0063159484,
-0.023680093,
-0.024547357,
0.009307383,
0.004267193,
0.004751101,
0.05394637,
-0.009081139,
-0.024082303,
0.0034753426,
-0.026395008,
0.0040598037,
0.0019670564,
-0.011098472,
0.020462416,
-0.002545233,
-0.00089240266,
0.018727886,
0.009074855,
-0.002331559,
-0.03577152,
0.007880795,
0.007434594,
0.0027573355,
0.014944602,
-0.0009073284,
-0.010891083,
0.016528303,
0.0069758235,
0.0028908818,
-0.01535938,
-0.004751101,
0.010821953,
0.011865185,
0.0031375494,
0.014404133,
-0.01974598,
0.009954688,
-0.0035947487,
0.015434795,
0.021681614,
0.004936495,
-0.018489074,
-0.014693221,
0.024358822,
-0.02052526,
0.0040598037,
0.010482589,
-0.003648167,
-0.0040943683,
-0.004807662,
0.04756129,
-0.008308142,
-0.0059734415,
0.005558663,
-0.01047002,
0.014278443,
-0.013813388,
0.008125892,
0.008509248,
0.021405093,
-0.0058540357,
0.009112562,
-0.013964216,
-0.022925949,
0.0058194706,
0.022498602,
0.020638382,
0.000555395,
-0.021291973,
-0.024786169,
0.014768635,
0.0049679177,
-0.025351776,
-0.04917013,
0.0002291888,
-0.013725404,
0.017445844,
0.020173328,
-0.02117885,
0.0056497883,
-0.030216,
0.003597891,
-0.019859102,
-0.011745778,
-0.022586586,
0.024258269,
0.01867761,
0.027274841,
0.046178695,
-0.013461454,
-0.010419743,
0.010790531,
0.037028424,
0.0018429371,
-0.002941158,
-0.00787451,
-0.0050778966,
0.0011084332,
-0.031724285,
-0.0085972315,
0.005976584,
-0.013310625,
0.020060206,
0.038059086,
0.00888632,
0.051105764,
-0.00655476,
0.010570572,
0.014768635,
0.002787187,
0.03167401,
0.0242457,
0.025892245,
-0.014454409,
0.009200546,
0.009213114,
-0.009169123,
0.015686177,
-0.01576159,
0.0018696464,
0.036148593,
0.02159363,
0.022033546,
0.002056611,
-0.024823876,
0.022234652,
0.0061274124,
0.0017690939,
0.0068564173,
-0.0128707085,
0.011632657,
0.0247736,
-0.025791693,
-0.0018492216,
-0.04811433,
0.010583141,
0.019859102,
-0.04861709,
-0.006812426,
-0.0030747042,
-0.013272918,
-0.017961174,
0.0048579383,
0.008842328,
0.022347772,
0.005678069,
0.013210073,
-0.0058760312,
0.0010919364,
-0.008572093,
0.011236732,
-0.0029081642,
-0.0016936796,
-0.007887079
] |
Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation, deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event in myeloid and lymphoid malignancies. TET2 gene mutations similar to those observed in myeloid and lymphoid malignancies also accumulate with age in otherwise healthy subjects with clonal hematopoiesis. TET2 is one of the three proteins of the TET (Ten-Eleven Translocation) family, which are evolutionarily conserved dioxygenases that cataly | [
-0.03365806,
0.0016092006,
0.013068354,
-0.015405347,
-0.024780178,
0.040481005,
-0.032341827,
-0.00705127,
-0.031670276,
0.015956016,
0.016896186,
0.0011684962,
0.008394369,
0.018467613,
-0.0076019405,
-0.0035289929,
0.031267345,
-0.010086674,
0.012960906,
0.011107429,
-0.032771617,
0.011611091,
0.0063662897,
-0.004150176,
-0.00047847905,
-0.0018299725,
0.03486685,
-0.04381189,
-0.0045833257,
-0.0026929136,
0.020898622,
-0.015660536,
-0.025384571,
-0.014988986,
-0.0015302935,
-0.008427947,
0.0047579287,
-0.0057551796,
0.012108038,
-0.025008505,
0.017285684,
0.03387296,
-0.00731989,
-0.006883383,
-0.0060036527,
0.025263693,
-0.01240352,
-0.013807058,
-0.016251499,
0.010274708,
-0.0011156116,
0.022752099,
-0.009603159,
-0.0014488681,
-0.016211206,
-0.02413549,
-0.0058995625,
0.032744754,
0.011953582,
-0.016184343,
0.0034752688,
-0.031724,
-0.02957504,
0.005275022,
-0.0035222773,
-0.009905356,
0.016721584,
-0.0066013318,
0.011778979,
0.00057585374,
0.024202645,
0.026418759,
-0.013175801,
-0.00028268038,
0.01653355,
-0.03201948,
-0.029709352,
-0.014854676,
-0.00034102125,
-0.0039453534,
0.036988948,
-0.024189213,
-0.022940133,
-0.00174435,
0.013122078,
0.013632456,
0.0007991439,
0.011933435,
0.010046381,
-0.007769828,
0.028419977,
0.01016726,
0.009294245,
0.025774071,
-0.02058971,
0.0056712357,
0.003915134,
0.02330277,
-0.011590945,
-0.030676382,
-0.01653355,
0.019971883,
0.0049761822,
0.0007294707,
-0.035296645,
-0.011053706,
0.0017712119,
0.01478752,
0.008132465,
-0.010825379,
-0.014612918,
0.038466357,
0.0115640825,
-0.043006033,
0.015794845,
-0.008085457,
0.0140219545,
0.016332084,
-0.014626348,
-0.010415733,
0.01803782,
-0.001085392,
-0.0012339723,
-0.038976736,
0.025720347,
0.006389794,
0.0026794826,
-0.029118387,
-0.012470675,
-0.010496319,
0.025236832,
-0.0011735328,
0.0034215448,
-0.009106211,
-0.015862,
-0.0001477409,
-0.009509142,
-0.021234397,
-0.009126358,
-0.02222829,
-0.0005641016,
0.021785067,
0.0048150104,
-0.0081861885,
0.005953287,
0.023504233,
-0.012020737,
0.013216095,
0.0039822888,
0.00025099164,
-0.013424275,
0.0017158091,
0.027439514,
-0.028500563,
0.017258823,
0.023114735,
-0.00058089034,
0.0034584801,
-0.0033392801,
-0.017299116,
-0.010046381,
-0.009791193,
0.0047411397,
0.0056376583,
0.029736213,
0.035269782,
-0.0014992343,
0.009253953,
-0.010986551,
-0.0029430657,
-0.007252735,
0.024713023,
-0.028419977,
0.01693648,
-0.0009938932,
0.009180082,
-0.0019441359,
0.019851005,
-0.035189196,
-0.018964559,
-0.0027332066,
0.04555792,
0.024699591,
0.0026576573,
-0.015553087,
-0.0030169364,
0.009341254,
0.007655665,
0.0005028227,
-0.015203881,
-0.004751213,
0.0034316182,
0.005778684,
-0.009408409,
-0.6176107,
-0.021100087,
0.02358482,
-0.012578122,
-0.0010954652,
0.025720347,
0.0072997436,
0.002674446,
-0.019783849,
0.017137945,
0.0013263103,
0.028984077,
-0.007675811,
-0.004160249,
-0.022805823,
-0.033550616,
-0.014357729,
-0.008669704,
0.0103620095,
-0.0055134217,
-0.009354685,
0.004009151,
-0.013242957,
0.0013842315,
-0.00022161135,
0.01206103,
0.035001162,
-0.010516466,
0.00025959586,
0.024216076,
0.0002522508,
0.03567271,
-0.009677028,
-0.0018350091,
0.045933988,
0.018319871,
0.008938325,
0.025384571,
0.007554932,
0.021731343,
0.007729535,
0.011013412,
0.013612309,
0.004522886,
0.00518772,
0.013444422,
0.006386436,
0.008750291,
0.021919377,
-0.014988986,
0.002380643,
-0.0068430896,
-0.009368116,
-0.005604081,
-0.01897799,
0.0016469752,
0.027694702,
-0.013699611,
0.03623681,
-0.0016117189,
-0.013914506,
0.03196576,
-0.013545154,
0.021677619,
0.004761286,
-0.00593314,
-0.008461524,
0.0047713593,
-0.0029447447,
-0.010415733,
0.031401657,
0.018682508,
0.008669704,
0.002860801,
0.041689795,
0.024605574,
0.025572605,
-0.017688615,
0.012121469,
0.027694702,
0.003021973,
-0.015271036,
-0.03430275,
0.003579359,
0.01830644,
0.007756397,
-0.014586056,
0.021314982,
0.0067826505,
0.017111082,
0.03838577,
-0.013558585,
-0.0066886335,
-0.034249026,
-0.01071793,
0.007850414,
-0.0049560354,
0.013209379,
0.024068335,
-0.010503035,
-0.031992618,
-0.017890079,
0.013746619,
-0.00259386,
0.00606745,
0.0154725015,
-0.04582654,
-0.014975554,
0.041448038,
0.008951755,
-0.015754553,
-0.009475564,
-0.01626493,
-0.0004276931,
-0.010281423,
-0.008716713,
0.006111101,
0.006211833,
-0.0053858273,
-0.029870523,
-0.0040360126,
-0.004962751,
-0.007494493,
-0.006691991,
0.009596443,
0.016372377,
0.0079645775,
0.007239304,
0.006027157,
-0.014599487,
-0.0009393299,
0.005264948,
0.019058576,
-0.03185831,
0.027076878,
-0.025290556,
0.023665406,
-0.0035760012,
0.0012096285,
-0.019448074,
-0.024001181,
-0.0124773905,
-0.0016268287,
-0.00854211,
-0.008253343,
-0.012490821,
-0.015499363,
-0.00025078177,
0.014747228,
0.0029967898,
-0.0132026635,
0.017057357,
-0.01328325,
0.0073668985,
0.0040460858,
-0.024847332,
-0.017728908,
-0.012222202,
-0.007877276,
-0.02222829,
-0.006786008,
0.013390698,
0.005788757,
-0.0047948635,
-0.017648323,
-0.020146485,
-0.005540284,
-0.0069639687,
-0.015244175,
-0.015015848,
-0.013699611,
-0.0023269192,
-0.0015856964,
-0.0242698,
0.016923048,
0.008320498,
0.009630021,
-0.0063125654,
0.0021120233,
0.0052615907,
-0.005711529,
0.0029514602,
-0.00042916212,
-0.015620242,
0.012336365,
0.026056122,
0.0076288027,
0.0004637889,
0.0066483403,
0.037633635,
-0.02046883,
0.02494135,
-0.014545763,
0.007675811,
0.021650758,
0.0026526207,
0.028500563,
0.0044389423,
-0.028903492,
0.036021918,
0.007816836,
-0.02480704,
-0.002765105,
-0.012484106,
0.025236832,
-0.015741121,
-0.019891297,
-0.020791173,
-0.0012079497,
0.011543936,
-0.01192672,
-0.0037237422,
-0.007823552,
0.021879084,
-0.024847332,
0.010550044,
-0.010979835,
0.004086379,
-0.006302492,
-0.011275317,
0.00542612,
-0.0034383335,
0.01694991,
-0.0075213546,
0.010281423,
-0.018964559,
0.013437706,
-0.003021973,
0.019367488,
-0.010113536,
-0.004855303,
0.015083003,
-0.0017132907,
0.011590945,
-0.013477999,
0.028903492,
-0.0006543411,
0.0084078,
0.04475206,
-0.012853458,
0.015969448,
-0.0063662897,
-0.0013036455,
-0.013551869,
0.0067927237,
0.00069463404,
0.025572605,
0.005536926,
-0.018467613,
0.020777743,
-0.0033006659,
0.031240484,
-0.016882755,
-0.022711806,
0.0051172073,
-0.014330867,
-0.0070311236,
0.02508909,
0.023450509,
0.014075678,
0.02725148,
-0.031159898,
-0.016681291,
-0.008401085,
-0.0044792355,
-0.000034311983,
0.0019357415,
0.0017779274,
0.01545907,
-0.000977944,
-0.022174565,
0.00955615,
-0.011637953,
-0.032341827,
0.01545907,
0.0037270999,
0.0045833257,
0.002649263,
0.017527442,
0.0044792355,
0.008495102,
-0.04759943,
0.03295965,
0.026660517,
-0.026230725,
-0.009327823,
-0.013887645,
0.008770437,
-0.0011030202,
0.021100087,
0.013424275,
0.013363835,
0.0062588416,
0.028634872,
-0.008938325,
-0.015136726,
0.026902273,
-0.012833311,
0.018628784,
0.004005793,
-0.0034920576,
0.006242053,
-0.029897384,
-0.001996181,
0.04378503,
0.026767964,
0.001823257,
-0.0103955865,
-0.0044658044,
-0.016251499,
0.0108992485,
-0.017393133,
-0.0017980739,
-0.044402856,
-0.01790351,
-0.024498127,
0.010200838,
0.0017728908,
0.008125749,
-0.005855912,
-0.025330849,
-0.019582385,
0.002661015,
-0.000330948,
0.015647104,
0.04134059,
-0.017325979,
0.004657196,
-0.021059792,
0.013021345,
0.00369688,
-0.0071385717,
0.02711717,
-0.014545763,
0.0064233714,
-0.012067745,
0.0020012176,
-0.016050033,
-0.0010056454,
0.02616357,
0.012101322,
-0.018064683,
-0.006043946,
0.004109883,
-0.0010249525,
-0.013142224,
0.02480704,
0.021261258,
0.014680073,
-0.018642215,
0.0066852756,
0.023517665,
0.028903492,
-0.00834736,
-0.009475564,
-0.0011785694,
-0.012296072,
0.018615354,
0.004774717,
-0.0076825265,
0.011429773,
0.016923048,
0.01857506,
-0.003780824,
0.020428536,
0.019394351,
0.013619024,
-0.002674446,
-0.0051306384,
0.012067745,
-0.013444422,
0.005943213,
0.013061638,
-0.023316199,
-0.0002686198,
-0.019273471,
-0.046820432,
-0.028285665,
0.0058894893,
0.00942184,
-0.0077362508,
-0.02154331,
-0.007427338,
-0.0063427854,
0.011013412,
-0.041528624,
-0.0008595834,
0.0006988312,
0.017957235,
-0.024041474,
0.0065912586,
-0.031025589,
-0.019756988,
-0.019730125,
-0.0026593362,
-0.0075952252,
-0.01762146,
-0.0046907733,
0.0059935795,
0.005029906,
0.020294227,
-0.015123296,
0.0073534674,
0.03650543,
-0.040158663,
-0.0009368116,
0.011825987,
-0.016587274,
0.008589119,
0.0032654095,
0.02061657,
-0.013363835,
-0.00084951014,
0.018601922,
0.019743556,
-0.017124513,
0.010066528,
0.00982477,
-0.004405365,
0.021852221,
0.008246629,
0.003485342,
-0.015217313,
0.0075952252,
-0.010590336,
-0.026660517,
-0.027466375,
-0.02629788,
-0.0020582993,
-0.025653193,
0.018252715,
0.01600974,
0.011208162,
-0.0055671455,
0.0014690146,
0.0037741084,
0.01071793,
0.0034685533,
0.013471284,
0.024108628,
-0.00028163107,
0.00069379463,
-0.0073400363,
-0.001623471,
-0.0023118092,
-0.01396823,
0.02100607,
-0.002436046,
-0.012900466,
0.0060036527,
-0.008421231,
-0.018776525,
-0.013034777,
0.011987159,
0.0009787835,
0.026915705,
0.0076892423,
-0.0057820412,
-0.016036604,
0.008515248,
-0.00022412966,
-0.0015991273,
0.002049905,
-0.02944073,
0.007581794,
0.01559338,
-0.0092270905,
0.0007920087,
-0.0007529749,
-0.029360145,
-0.030971864,
0.034625094,
0.023947457,
0.002687877,
-0.008401085,
-0.00076724536,
-0.017527442,
-0.015056141,
-0.001204592,
-0.04633692,
-0.0013355442,
-0.013901075,
0.037875395,
0.031240484,
0.031213623,
-0.012067745,
0.036693465,
0.010946257,
0.020844897,
0.019756988,
-0.004600114,
0.013175801,
-0.00921366,
-0.0055973656,
0.00603723,
0.0012650314,
0.030891279,
-0.016466394,
0.014183126,
0.022282014,
-0.0088174455,
-0.0204554,
0.019595815,
-0.050527386,
-0.030273452,
0.02195967,
-0.016076896,
-0.005681309,
-0.038278323,
0.00854211,
0.03309396,
0.0078034056,
0.002686198,
0.022470048,
0.026056122,
0.0019189528,
0.010576905,
-0.0008822482,
0.0020582993,
0.013316827,
-0.0125714075,
0.004113241,
-0.011980443,
0.012631847,
-0.01680217,
0.010066528,
-0.005214582,
-0.024927918,
0.021852221,
0.0049056695,
-0.031482242,
0.00086042285,
-0.025398003,
-0.0061547514,
-0.0017594597,
-0.029172111,
-0.016560411,
-0.039943766,
0.026633654,
0.026351603,
-0.037848532,
0.017849786,
-0.0028843053,
-0.031885173,
0.023705699,
-0.02277896,
0.029521318,
0.0026845192,
0.026808258,
0.007635518,
0.008649558,
-0.024189213,
-0.0112148775,
0.0065106726,
-0.0032116857,
0.0349743,
0.019582385,
-0.01639924,
0.00323519,
0.008213051,
-0.01532476,
-0.024095196,
-0.019233178,
0.0054764864,
-0.023517665,
0.012927328,
-0.010462741,
-0.005080272,
-0.03118676,
-0.0032586942,
-0.0032234378,
0.009992657,
-0.02725148,
-0.011967013,
-0.0036263675,
0.009992657,
-0.00969046,
0.010858956,
0.016345516,
-0.008562257,
-0.0014765696,
-0.03755305,
-0.025290556,
0.012631847,
0.012752726,
0.03432961,
-0.023410216,
-0.01626493,
0.0065778275,
-0.010415733,
-0.00654425,
-0.0102679925,
-0.020186778,
0.043328375,
-0.013860783,
0.0026929136,
0.010959689,
0.007037839,
0.0048082946,
-0.009683744,
-0.0048217257,
-0.009193514,
-0.03997063,
0.007575079,
0.014156264,
0.007293028,
-0.005986864,
0.001402699,
-0.023423648,
-0.014492039,
-0.037257567,
-0.04093766,
0.032637306,
-0.05898891,
0.0046336916,
0.0022564065,
-0.002076767,
0.0011382764,
0.0026979502,
0.0011256849,
0.009623305,
0.050500523,
-0.02046883,
0.009260668,
0.011832703,
0.016063465,
-0.008011586,
-0.0042811283,
-0.009079349,
-0.021220965,
0.010556758,
-0.017272254,
-0.020549417,
-0.0012406878,
0.015096433,
-0.0050399792,
0.008589119,
-0.02549202,
0.010355294,
0.0014799273,
0.02699629,
0.0079645775,
-0.021583602,
0.022161135,
-0.027479807,
0.011758832,
-0.0052615907,
-0.0050869877,
-0.024699591,
0.0030118995,
-0.017675184,
-0.012618416,
0.00066021713,
-0.009596443,
-0.02291327,
0.00654425,
0.012826596,
0.0151904505,
0.00032549165,
-0.0038144013,
-0.010409018,
-0.0045195282,
-0.0049661086,
-0.011973728,
-0.012336365,
0.014169695,
-0.011819271,
0.008642842,
-0.016627567,
-0.015069571,
0.0034416914,
-0.027748426,
-0.037767947,
-0.0010618877,
-0.0129810525,
0.014935262,
0.0055033485,
-0.006043946,
-0.018816818,
-0.0153784845,
-0.055013336,
-0.009683744,
0.015485932,
-0.0055570723,
0.023249045,
0.02927956,
-0.025236832,
0.002634153,
0.0036767337,
0.010818663,
-0.020495692,
-0.025948673,
0.006735642,
0.014599487,
0.0132966805,
0.0062621995,
-0.03771422,
-0.017017065,
0.019904729,
0.014304005,
-0.0011634596,
0.016627567,
-0.021449292,
0.019864434,
-0.00785713,
0.0007047073,
-0.013048207,
0.005029906,
0.0030807336,
-0.0105836205,
-0.0055637877,
0.0028574432,
0.013874213,
-0.0009023947,
0.014518901,
0.0026996292,
0.01192672,
-0.0115305055,
-0.0046605538,
-0.010966403,
0.0015336513,
-0.022416323,
0.018521337,
0.03295965,
0.006745715,
0.0046538385,
0.012987768,
0.00069547346,
0.0033241701,
-0.016103758,
-0.02033452,
-0.01423685,
0.0060103685,
-0.0011584229,
0.0118461335,
0.008461524,
-0.0070109772,
-0.032207515,
-0.027090307,
0.00681287,
-0.01979728,
-0.028043909,
0.0012977695,
-0.012396804,
-0.034222163,
-0.0070042615,
0.0017577809,
-0.013263104,
-0.009683744,
-0.006218549,
-0.0046639116,
-0.020374812,
-0.009589727,
-0.0010165581,
0.0010795159,
-0.005526853,
-0.011443204,
-0.014706935,
-0.011228308,
0.024592144,
0.19491054,
-0.008891316,
0.004563179,
0.015203881,
-0.0031831448,
0.013504861,
0.026955998,
-0.019179454,
-0.0016008063,
-0.0020180063,
0.009462133,
0.020441968,
0.0023537811,
-0.0033376012,
-0.00057585374,
0.0025451728,
-0.031724,
0.00867642,
-0.039836317,
-0.01584857,
-0.016023172,
-0.010220984,
0.015687397,
-0.02359825,
0.029064665,
0.00069673266,
-0.022214858,
-0.00026001557,
0.022161135,
-0.010409018,
-0.03252986,
0.013592162,
-0.005536926,
-0.016466394,
0.003193218,
-0.002263122,
-0.013531723,
-0.015808277,
-0.014250281,
-0.010825379,
-0.002075088,
0.00184844,
-0.013699611,
-0.008045163,
-0.0107045,
0.021046363,
0.009650167,
0.0007000904,
-0.007756397,
-0.022980426,
-0.051064625,
-0.00020366839,
0.006997546,
0.0059969374,
0.006477095,
0.0010996624,
0.04596085,
0.0074609155,
-0.017594598,
-0.0034887,
-0.007266166,
0.0008247468,
-0.03403413,
0.023369923,
0.0018534767,
0.049130563,
-0.020710588,
-0.0044893087,
0.022161135,
-0.024189213,
0.0059398557,
-0.015647104,
-0.022416323,
0.0126117,
-0.015553087,
-0.021892514,
0.031616554,
0.02576064,
0.0056578047,
0.011228308,
0.008965186,
0.0021875727,
-0.012014021,
0.013598878,
-0.012114754,
-0.026338173,
0.01817213,
0.009334538,
-0.009388262,
0.0020650148,
0.009294245,
-0.015956016,
-0.004684058,
0.0049560354,
0.0030975223,
0.014075678,
0.008709998,
-0.018131837,
-0.012799734,
-0.04297917,
-0.03105245,
0.07021722,
0.015096433,
0.018467613,
-0.021758204,
0.027439514,
-0.00062957767,
-0.012826596,
-0.0047713593,
-0.001197037,
0.0142099885,
-0.028930353,
0.008206335,
0.009791193,
0.009119643,
0.02209398,
-0.0030673025,
-0.022443185,
0.026929136,
-0.02209398,
0.027305204,
-0.035565265,
0.0056074387,
0.031535964,
-0.025975537,
0.019098869,
-0.03064952,
-0.010194122,
-0.020764312,
-0.019743556,
-0.0069371066,
0.0060842386,
0.021046363,
0.018252715,
0.0025854658,
-0.01666786,
0.0064334446,
-0.01559338,
-0.05423434,
0.022819253,
-0.0060741655,
0.0009023947,
-0.0058861314,
0.008354076,
0.00521794,
-0.0426031,
0.025518883,
-0.014881537,
-0.02914525,
-0.03537723,
-0.02248348,
-0.026929136,
-0.0029027727,
0.0089450395,
0.036666606,
-0.026082983,
0.0009661919,
-0.04569223,
0.008307068,
0.011758832,
-0.022107411,
0.025680054,
0.025854656,
0.00049232977,
-0.01842732,
0.0007172988,
-0.16912304,
-0.019045144,
0.020576278,
-0.025411434,
0.025236832,
0.0047344244,
0.02264465,
-0.017661752,
0.0088846,
0.0139548,
0.044053648,
-0.0118461335,
-0.035054885,
-0.0036935224,
-0.024793608,
0.03064952,
-0.007924285,
0.024524989,
0.017124513,
0.0017611387,
0.025317417,
-0.013216095,
0.031374793,
-0.009368116,
0.0046202606,
0.015512794,
0.022335738,
-0.0223626,
0.010825379,
0.0005796312,
-0.022698374,
0.0036263675,
0.03105245,
-0.00085874397,
0.027479807,
-0.01857506,
0.0104896035,
-0.0001109106,
0.007158718,
0.009865062,
0.017500581,
0.012920613,
0.00016222119,
-0.008998764,
-0.012840027,
0.032502998,
0.006866594,
-0.0050869877,
0.023262477,
-0.012188624,
0.03048835,
-0.014398022,
0.01159766,
0.016466394,
0.033819236,
0.006822943,
0.0040360126,
0.01064406,
0.0010971441,
-0.015821707,
-0.014290574,
-0.006104385,
0.022765528,
-0.020025607,
0.0011475103,
-0.04174352,
-0.011355903,
-0.010979835,
-0.038197737,
0.010751508,
-0.02303415,
-0.00921366,
0.019985314,
0.0076220874,
0.014304005,
0.005019833,
-0.022147704,
0.0028775898,
-0.0019407781,
-0.00089232146,
-0.02332963,
0.0223626,
-0.024699591,
-0.0012339723,
-0.025854656,
0.013753334,
0.009831485,
-0.0007391242,
0.00731989,
-0.0068061543,
0.014894969,
-0.014599487,
0.025854656,
-0.018615354,
0.01085224,
0.031025589,
-0.00323519,
0.01112086,
0.0003202452,
0.0044758776,
-0.000020421927,
-0.027399221,
-0.015606811,
0.0030505138,
0.040078077,
0.0051810048,
-0.0142099885,
0.007313174,
0.01611719,
0.014048817,
-0.0016662823,
0.007568363,
0.0011836061,
0.008011586,
0.0021405641,
0.033362582,
-0.01478752,
0.0015579949,
0.0030437983,
0.007971293,
0.08176787,
-0.006346143,
-0.017916942,
0.014424884,
-0.014948692,
-0.013095216,
-0.11969699,
-0.010207552,
0.03134793,
0.017017065,
-0.0069774,
0.015230743,
-0.0048250835,
0.025277125,
-0.0093211075,
0.023356494,
-0.030542072,
-0.0089114625,
-0.0019877865,
0.0022648007,
0.00976433,
-0.005389185,
0.013424275,
-0.007554932,
-0.020831466,
0.047680017,
0.0022950205,
0.0008755327,
0.0093211075,
-0.03252986,
-0.004297917,
-0.01173197,
-0.05111835,
0.023934025,
0.003448407,
0.009334538,
0.017379701,
-0.0052918103,
0.025693486,
0.021932807,
-0.014532332,
0.013753334,
0.004432227,
-0.029843662,
0.0479755,
-0.020495692,
-0.022590926,
0.024202645,
-0.0079645775,
0.016896186,
0.01979728,
-0.043059755,
-0.0074541997,
0.005976791,
0.020938914,
-0.04190469,
-0.030864416,
-0.034249026,
-0.013363835,
-0.02155674,
0.0064972416,
-0.005003044,
0.026217293,
0.03064952,
-0.029118387,
0.0059700753,
0.02954818,
-0.021073224,
0.008958471,
0.0052112243,
0.018763093,
-0.036424845,
-0.018467613,
-0.039137907,
0.033147685,
-0.023947457,
-0.016923048,
0.008898031,
-0.027667841,
-0.025142815,
-0.025518883,
0.014048817,
-0.015029279,
-0.006389794,
0.018373596,
-0.03457137,
-0.034195304,
-0.018387027,
0.008072025,
-0.014183126,
0.04174352,
0.008615981,
-0.0049661086,
-0.0029061306,
0.028419977,
-0.021314982,
-0.027587255,
0.033443168,
-0.011879711,
-0.0058223344,
-0.011899858,
0.030434625,
-0.006453591,
-0.008797299,
0.025478588,
0.029628765,
-0.023477372,
-0.028097633,
-0.06731612,
0.033846095,
0.0093614,
0.0027080234,
0.027614117,
0.0066886335,
0.008166042,
0.0054361937,
0.014048817,
0.03524292,
-0.010462741,
0.016063465,
-0.0063125654,
-0.03717698,
-0.00040859592,
0.0004822565,
0.030327177,
0.005855912,
0.023544526,
0.020804605,
0.005949929,
-0.0072325883,
0.01696334,
0.027399221,
0.010550044,
-0.0043617142,
0.008125749,
0.02588152,
-0.011161153,
0.016184343,
0.016721584,
-0.03212693,
0.00901891,
-0.011342471,
-0.011960297,
-0.03634426,
0.0155665185,
0.023020718,
0.016855894,
0.03158969,
-0.016305223,
-0.019998744,
0.02075088,
0.011483497,
-0.0004453213,
0.0026240798,
-0.017339408,
0.007843698,
0.0050097597,
0.029333284,
0.03376551,
-0.009186798,
-0.005879416,
-0.010811947,
-0.021879084,
-0.021986531,
0.012913898,
-0.012510967,
-0.00012266272,
0.0036230097,
0.009374832,
0.0105836205,
0.022550633,
0.00008835074,
0.0077899746,
-0.009583012,
-0.031401657,
-0.0064435177,
0.014814382,
-0.032100067,
-0.012853458,
0.0049191,
0.012034168,
0.021919377,
0.013753334,
0.009536004,
-0.021341844,
0.011799125,
-0.00033640434,
0.016036604,
0.006131247,
-0.014304005,
-0.027506668,
-0.0048955963,
0.02224172,
0.0048754495,
-0.013122078,
0.036532294,
0.000016041115,
0.00593314,
0.0037606773,
0.02385344,
-0.004254266,
0.02087176,
0.010066528,
0.0409108,
0.013592162,
-0.001469854,
0.0069303913,
0.060922973,
-0.0142099885,
-0.012833311,
-0.0074407686,
-0.019985314,
-0.017164806,
0.027358929,
-0.02075088,
-0.03728443,
-0.027963322,
-0.0061278893,
0.007313174,
0.012766156,
-0.015781414,
-0.0008730144,
-0.010952973,
-0.02154331,
0.008179474,
-0.009368116,
-0.021395568,
0.0210195,
0.0067759347,
0.011355903,
0.007225873,
-0.014962124,
0.04066904,
0.0026307954,
0.031777725,
-0.030273452,
0.014492039,
-0.0059835063,
0.0038211169,
0.015781414,
-0.03876184,
-0.015002416,
0.006346143,
-0.006228622,
0.027426083,
0.0063797208,
0.0032939503,
0.095843546,
0.008454809,
-0.022470048,
-0.0038379056,
-0.025680054,
0.017151374,
0.027614117,
0.030730106,
-0.013652602,
-0.026096415,
0.014827814,
-0.024551852,
0.02330277,
-0.028231943,
-0.039621424,
0.0029514602,
0.00077941717,
-0.00052003114,
-0.004657196,
0.010194122,
0.006634909,
-0.004079663,
0.009536004,
0.0037472465,
0.00051079737,
-0.0006845608,
0.046739846,
-0.011322325,
-0.014827814,
-0.042146448,
0.008656274,
-0.018763093,
-0.032476135,
-0.015029279,
0.023383355,
-0.023772852,
0.009985941,
-0.03403413,
0.03134793,
0.011369334,
0.009381547,
0.02127469,
-0.020253934,
-0.028822906,
0.0051440694,
0.010697784,
-0.020643432,
-0.013793628,
-0.005194436
] |
OBJECTIVE To determine the prevalence and clinical associations of impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS A validated questionnaire was administered to 656 patients with type 1 diabetes over a 6-month period to determine hypoglycemia awareness status. Case ascertainment was 79% of the clinic population. The rate of severe hypoglycemia was determined by data collected prospectively in the preceding year. RESULTS Impaired awareness of hypoglycemia was present in 29% of patients. Patients with impaired awareness of hypogly | [
0.0069500813,
-0.015814241,
0.03181329,
-0.04768033,
-0.006725672,
0.0011327709,
0.011174252,
-0.013418344,
-0.01951039,
-0.026150258,
-0.0046498883,
0.0001866638,
-0.0060821464,
-0.007009484,
-0.0019866806,
0.0067850747,
0.034664605,
-0.009233774,
-0.018903166,
-0.014877003,
-0.014243376,
0.00617125,
-0.008355939,
0.014005767,
-0.0018051731,
-0.016355462,
0.012309498,
-0.033687763,
0.011537267,
-0.01333254,
0.01925958,
-0.018889965,
-0.025384627,
0.0015667385,
-0.007062286,
-0.011326059,
-0.0001654192,
-0.023655359,
0.03178689,
-0.034189384,
0.021530071,
0.022625716,
-0.0023067934,
0.002666508,
-0.01630266,
0.010692433,
-0.0046828897,
-0.0039304593,
-0.020632435,
0.00963639,
-0.0038446556,
0.024460591,
-0.0020081312,
-0.0016789429,
0.01134586,
-0.005785134,
0.008039125,
0.023061333,
-0.009900401,
-0.016936285,
-0.020883245,
0.006709172,
-0.025846647,
-0.003877657,
0.008540746,
-0.00071200385,
0.003186279,
0.0021813884,
0.0172663,
-0.010936643,
0.031522878,
0.03653908,
0.010342618,
-0.018071532,
0.02395897,
0.0072932956,
0.021477269,
-0.021147257,
0.008956563,
0.01060663,
0.014586591,
-0.015655834,
-0.023034932,
0.052194912,
-0.0030047717,
0.0067850747,
0.0054221195,
0.022823725,
0.0012812769,
0.0006348632,
-0.0054452205,
0.011530667,
0.009233774,
0.019549992,
0.007986323,
0.02343095,
0.0017573212,
0.03157568,
-0.0006715772,
0.006438561,
-0.029489994,
0.015022208,
-0.026731083,
-0.021873286,
0.0013134532,
-0.010072008,
-0.0076101082,
0.013596551,
-0.013570149,
0.011959684,
-0.011557068,
0.058451965,
-0.009220573,
0.006092047,
-0.020183617,
-0.0014124572,
-0.0137813585,
0.0067289723,
-0.018480748,
-0.025543034,
0.013418344,
0.0131543325,
0.023774162,
-0.018639155,
-0.005309915,
0.011510866,
-0.031417273,
-0.014507388,
-0.016183855,
-0.027351508,
-0.014098171,
0.0119926855,
0.026216261,
-0.012230296,
0.013886962,
0.02518662,
-0.031522878,
0.008421941,
-0.019378385,
-0.010672633,
0.0033958375,
0.028090738,
0.001603865,
0.011563668,
-0.0071942913,
0.027562717,
0.032473315,
0.008210733,
-0.029463593,
0.0036895494,
-0.010190813,
-0.0020229819,
-0.00567293,
0.008659551,
0.030229224,
0.0030955253,
0.015589831,
0.016461067,
-0.032526117,
-0.0023150437,
-0.018401545,
-0.004296774,
0.0002173963,
0.0032242306,
-0.02492261,
0.013253337,
-0.009623189,
-0.010976245,
0.014018968,
-0.0049799015,
-0.017187096,
0.028460352,
-0.004474981,
-0.008012724,
-0.007214092,
0.006095347,
0.028196342,
0.0071282885,
-0.021437667,
-0.027589118,
-0.033344552,
0.027800325,
0.008217333,
0.020645635,
-0.0137813585,
0.008349339,
0.03928479,
0.0059336405,
0.013358941,
-0.013728556,
0.022097696,
0.032473315,
0.012316098,
0.014982606,
-0.6247549,
-0.011200653,
0.017134294,
0.0023628958,
-0.0024800505,
0.021530071,
0.010164412,
0.012019087,
0.0069302805,
0.039944816,
0.013081729,
0.020421227,
-0.018493949,
-0.041792892,
-0.0069764825,
-0.01112145,
-0.015985847,
-0.008204132,
0.021173658,
-0.025424229,
-0.0071480894,
-0.0079071205,
0.0005581351,
0.0073064957,
0.0127583165,
0.027377909,
0.010817838,
-0.020645635,
0.014005767,
0.019919606,
-0.00013045841,
0.014692195,
0.02591265,
0.04469701,
0.041687287,
-0.03582625,
-0.005504623,
0.00938558,
-0.013715356,
0.0419777,
-0.016170654,
-0.0105076255,
0.03432139,
0.009807997,
-0.0060425447,
0.017239898,
-0.027932331,
-0.003186279,
0.03830795,
0.007781715,
0.017477509,
0.002003181,
-0.020962449,
-0.0049502007,
0.014612991,
-0.015378622,
0.010078608,
0.0008811357,
0.007874119,
-0.007359298,
-0.025622237,
0.018071532,
-0.0013860562,
-0.011411862,
-0.038387153,
0.048445962,
0.0044617807,
0.022176899,
0.018401545,
-0.0086727515,
0.025859848,
0.017873524,
-0.0057092314,
0.018916367,
0.035034217,
-0.0030394231,
0.013926564,
0.019642396,
-0.015655834,
-0.010012605,
0.007676111,
0.013636152,
-0.016408265,
-0.009728794,
0.02545063,
0.013035528,
0.00026751708,
0.020856844,
-0.011636271,
-0.007940122,
0.01038222,
0.014401783,
0.0020906348,
-0.012916723,
-0.01036902,
0.029463593,
-0.031496476,
0.006765274,
0.046571486,
-0.005012903,
-0.01853355,
-0.01949719,
0.0026137058,
-0.013675754,
0.008725554,
0.0072206925,
-0.014533789,
-0.012738516,
0.043350555,
-0.041344073,
0.008666151,
-0.004887498,
-0.0011954734,
-0.0005960866,
0.019457588,
-0.02271812,
0.011035647,
0.012190694,
-0.00091991224,
-0.019431187,
-0.021120856,
-0.0019371784,
0.030176422,
0.00088443584,
-0.003283633,
0.00666297,
0.0021846886,
-0.015246618,
0.0012226995,
-0.015048609,
-0.012250097,
0.0077883154,
0.00059979927,
0.009194172,
0.018823963,
-0.028697962,
0.018097933,
-0.014388583,
-0.009365779,
-0.020051612,
-0.005210911,
0.003508042,
-0.006593667,
-0.018361943,
-0.015735038,
-0.0028249144,
-0.011557068,
-0.0077025117,
0.010316217,
0.007847718,
0.01925958,
-0.018639155,
0.0068510775,
0.028222743,
-0.0035641443,
-0.013979366,
-0.015167414,
-0.0065573654,
0.012936524,
0.0053231157,
0.008613349,
0.023153737,
0.006748773,
-0.01578784,
-0.008949962,
-0.02246731,
-0.0050459043,
0.0018876764,
-0.030176422,
-0.017173896,
-0.017820721,
-0.023021732,
-0.0074715028,
0.015418224,
0.010329418,
0.014797799,
-0.008520945,
0.0032770326,
-0.0020823844,
-0.0046135867,
0.018388344,
0.0088113565,
-0.026955491,
0.0045871856,
0.020870045,
-0.013127931,
0.012415103,
0.0049865018,
0.004366077,
0.011735275,
-0.022335304,
0.041396875,
-0.009893801,
0.007181091,
-0.039918415,
0.02790593,
0.005286814,
0.0065837665,
-0.03360856,
0.044089787,
0.06299295,
-0.008751955,
0.020421227,
-0.016263058,
0.022638917,
-0.014811,
0.0072932956,
0.0027325107,
0.012302898,
0.0019569793,
0.008078727,
-0.00041272296,
0.027193101,
-0.0013959565,
-0.016342262,
0.007207492,
-0.017939527,
0.0026681582,
-0.020091213,
0.00041189793,
0.020856844,
-0.0045904857,
0.026018254,
-0.007821317,
0.0124811055,
0.010580229,
0.017992329,
0.0107848365,
-0.010652832,
-0.010837639,
-0.015154214,
0.0039931615,
0.015035409,
0.034215786,
0.0020642336,
0.016342262,
0.006771874,
-0.010989445,
0.0035344432,
0.03630147,
-0.027589118,
0.020883245,
0.02270492,
-0.0017408205,
0.0041779694,
-0.00025328525,
0.02345735,
0.011240255,
-0.031496476,
0.025556235,
0.00036280844,
-0.0032539319,
-0.000114370254,
0.011920082,
-0.021992091,
0.0132929385,
-0.010487825,
-0.0024239481,
0.0014586591,
0.032658122,
0.02246731,
0.020619236,
-0.0008089453,
0.0006810651,
0.010652832,
-0.015101411,
0.001036242,
0.017147494,
-0.006620068,
-0.017002288,
-0.041660886,
-0.020632435,
-0.004953501,
-0.02369496,
0.0247246,
0.006884079,
-0.011299658,
-0.018889965,
0.039733607,
0.009042366,
-0.020949248,
-0.013180734,
0.019035172,
0.03191889,
0.0031433774,
-0.01036902,
-0.0010230414,
0.0031252266,
-0.0065573654,
0.0008473093,
-0.009774996,
0.0022770923,
0.012058688,
-0.018969169,
0.011398662,
0.010045607,
0.024896208,
0.0023859965,
-0.012085089,
-0.0039601605,
-0.007913721,
0.015510628,
-0.024751002,
0.004395778,
0.042901736,
0.011015846,
-0.0057521327,
-0.020540033,
-0.007728913,
0.0025757544,
0.0074715028,
0.0010915193,
0.007827917,
0.038096745,
0.020210018,
0.00073180464,
-0.024117377,
0.009609989,
0.020117614,
-0.009669391,
-0.018071532,
-0.023510152,
0.009332778,
0.011405262,
0.04643948,
0.016329061,
0.009365779,
0.025081016,
0.0007643935,
0.019048372,
-0.021648876,
-0.012137892,
0.025556235,
0.013900163,
0.009959803,
0.023879766,
0.015101411,
-0.011524066,
0.015853843,
0.014705395,
-0.019219978,
-0.01607825,
0.015906645,
0.018850364,
-0.008936762,
-0.0156162325,
0.012283097,
0.046360277,
0.012962925,
-0.03434779,
0.023919368,
0.0296484,
-0.011913482,
0.004887498,
-0.009220573,
0.027958732,
-0.0041053663,
0.01358335,
-0.015180615,
0.015193815,
0.004593786,
-0.000069302805,
0.031417273,
-0.010316217,
0.027298706,
0.013926564,
0.0021632377,
0.0032225805,
0.004534384,
-0.00789392,
0.014045369,
0.04271693,
-0.019589594,
0.003428839,
0.043825775,
-0.009669391,
-0.008547346,
-0.013649353,
0.012566909,
0.0031549279,
0.016170654,
-0.022757722,
-0.0042604725,
-0.0071546896,
-0.015457826,
-0.012395302,
0.01383416,
-0.014956206,
-0.03920559,
-0.010190813,
-0.002861216,
-0.032209303,
-0.023510152,
-0.000035450656,
0.023180138,
0.010223814,
-0.007986323,
0.012533908,
0.017992329,
0.0053990185,
0.0063362564,
-0.010811238,
0.014401783,
-0.004323175,
-0.018427946,
-0.004639988,
0.0026896088,
-0.011154451,
0.024315385,
0.0070490856,
0.019061573,
-0.023906168,
-0.014863802,
0.0048973984,
-0.028011534,
0.0035212426,
0.027747523,
0.0073460974,
0.008237134,
-0.017596312,
0.026387868,
0.018889965,
-0.025727842,
-0.023813764,
0.019972408,
-0.0031202764,
-0.02769472,
-0.022863327,
0.004379277,
-0.0011500965,
-0.037595123,
-0.001851375,
0.007187691,
-0.024460591,
-0.006818076,
0.00035785825,
0.015893444,
-0.005702631,
0.051534887,
0.010501025,
-0.008316337,
0.029569197,
0.0021450869,
0.0039370595,
0.0043726773,
-0.020447629,
0.023153737,
0.024143778,
-0.02493581,
0.023510152,
0.0018101233,
-0.019351983,
-0.027958732,
-0.027034694,
-0.016711878,
0.027985133,
-0.007933522,
-0.01875796,
-0.020210018,
-0.002615356,
-0.01800553,
-0.008382339,
-0.0032192804,
-0.024962211,
-0.005012903,
0.0004785194,
0.005161409,
-0.013127931,
0.049264394,
-0.034374192,
-0.0053198156,
-0.007629909,
-0.022282502,
0.008078727,
-0.009451583,
0.0075903074,
-0.033238947,
-0.009768396,
-0.0027259104,
-0.03727831,
0.008534146,
0.017411506,
0.023853365,
0.015418224,
0.01949719,
0.013504147,
0.01705509,
0.009689192,
-0.0032737325,
0.026704682,
0.005405619,
-0.0020889847,
0.011035647,
0.005240612,
-0.011458064,
-0.0011187453,
0.02175448,
-0.019589594,
0.038202345,
0.017015489,
-0.017754719,
-0.020276021,
-0.021464068,
-0.050610848,
0.0048280954,
-0.0043891775,
0.0093459785,
0.018665556,
-0.06890679,
-0.03154928,
0.018863564,
-0.0127121145,
-0.00058824883,
-0.02740431,
0.013728556,
-0.041845694,
0.018124335,
0.0024932509,
0.021820484,
0.005804935,
-0.025133818,
0.005870938,
-0.020922847,
0.0039370595,
0.03331815,
-0.018797562,
0.003385937,
-0.008652951,
-0.028618759,
0.026031455,
-0.01087064,
-0.0022655418,
-0.009768396,
-0.024909409,
-0.0036928495,
0.0072404933,
-0.018850364,
0.005653129,
-0.009735394,
0.025767444,
-0.025239423,
0.0247246,
-0.031522878,
-0.015919846,
-0.016659075,
-0.01012481,
0.018586352,
-0.0052934145,
0.016936285,
0.01803193,
-0.02046083,
-0.010534027,
0.015880244,
0.028909171,
-0.009273375,
0.016711878,
0.003508042,
-0.009695793,
-0.025767444,
0.0048049944,
0.021701679,
0.007458302,
-0.03500782,
0.021556472,
0.024460591,
-0.017160695,
-0.007491303,
-0.030440433,
-0.018863564,
0.034691006,
0.0064748623,
-0.009200772,
0.0027754123,
-0.017728318,
-0.005164709,
0.044617806,
-0.03725191,
0.0091149695,
0.0088113565,
0.0024074474,
0.00542872,
-0.00888396,
-0.026110657,
0.0016649175,
-0.01683068,
-0.0039832615,
-0.025833447,
0.019404786,
0.0006328006,
-0.013517347,
0.006725672,
0.010765036,
-0.028090738,
0.024236182,
0.0005152334,
-0.026757484,
0.013952965,
-0.010072008,
-0.0032143302,
0.009840999,
-0.018401545,
-0.025490232,
-0.010481224,
-0.0071546896,
0.03036123,
0.018190337,
-0.008751955,
0.01679108,
-0.033159744,
0.003755552,
-0.015273019,
-0.02440779,
0.010012605,
-0.01755671,
-0.010712233,
-0.008560547,
0.00084565923,
-0.009821198,
0.0065078638,
-0.0026137058,
0.0013373792,
0.017015489,
-0.020117614,
0.0040690647,
0.032182902,
0.0052703135,
-0.014612991,
-0.00005192554,
-0.026863087,
-0.030414032,
0.03139087,
0.015761439,
-0.046043463,
-0.011708874,
0.012217095,
0.015589831,
-0.009801397,
-0.00058824883,
0.017675515,
0.009675992,
0.009887201,
0.0077487137,
-0.034849413,
0.041845694,
-0.055495046,
0.024222981,
0.021081254,
-0.0125735095,
0.015022208,
0.002663208,
0.011405262,
-0.015695436,
-0.034189384,
0.000862985,
-0.03920559,
0.04345616,
-0.02843395,
0.0088113565,
-0.021411266,
0.0069368808,
-0.015114612,
0.02298213,
0.013886962,
-0.0017606213,
-0.026150258,
-0.010567028,
-0.0057752337,
0.02397217,
0.0021071353,
0.0070028836,
-0.009510986,
-0.0050690053,
-0.025397828,
0.0036433476,
-0.015484227,
0.033133343,
0.004168069,
-0.009590188,
-0.02864516,
-0.03012362,
-0.015154214,
0.029305186,
0.00042056077,
0.01655347,
0.004844596,
0.020592835,
0.0019553292,
0.004125167,
-0.007940122,
0.018599553,
-0.04052564,
-0.01750391,
0.020896446,
-0.0056927307,
0.014652593,
-0.029199582,
-0.0020922846,
-0.019140774,
0.018058332,
-0.003970061,
0.016183855,
0.03160208,
-0.002641757,
0.0068906792,
-0.002565854,
0.0107848365,
-0.00841534,
-0.010547227,
-0.013886962,
-0.012065289,
-0.004564085,
-0.016091451,
-0.012929924,
-0.008012724,
-0.02394577,
0.014480987,
-0.012203895,
0.012296298,
-0.032658122,
-0.008600148,
-0.010672633,
-0.0052439123,
0.007280095,
0.016434666,
0.011596669,
0.006963282,
0.009451583,
0.01283092,
0.0019388285,
0.010230415,
-0.014744997,
0.00037848408,
0.0057389326,
-0.022361705,
-0.011154451,
0.00055277237,
0.0023612457,
-0.019536791,
0.028275546,
-0.006395659,
-0.03477021,
-0.042505722,
0.011022447,
-0.0077949157,
-0.015893444,
-0.005527724,
-0.0010090158,
0.0017903225,
0.0010807938,
-0.009959803,
0.0073922994,
-0.026493473,
0.0070490856,
-0.010085208,
-0.00814473,
0.013121331,
0.0021516872,
0.008738754,
-0.019708399,
0.011596669,
0.19008769,
-0.0075045037,
0.010204013,
0.009075368,
0.00015572505,
0.009095169,
0.026612278,
0.011821079,
-0.0054221195,
0.0025856546,
0.021860085,
-0.027958732,
-0.015418224,
-0.0014718596,
-0.0013844061,
-0.011451464,
-0.02440779,
-0.021635676,
-0.015431425,
-0.031470075,
-0.0001562407,
-0.009530786,
0.015167414,
-0.0003442452,
0.036407076,
-0.0073262965,
0.00839554,
0.004791794,
0.04245292,
0.030229224,
-0.01605185,
0.013035528,
-0.00052802137,
0.01135246,
-0.022401307,
-0.0042901738,
0.024645397,
-0.009200772,
-0.013114731,
0.011781477,
-0.008131529,
-0.0005201836,
-0.02121326,
-0.008204132,
-0.0027440612,
0.002663208,
0.00469279,
-0.03384617,
-0.009293176,
0.0071282885,
-0.022335304,
-0.025028214,
-0.0011649472,
0.02299533,
-0.007979723,
-0.01824314,
0.015959445,
0.0012350751,
-0.023879766,
0.017635914,
0.005171309,
0.0007157165,
-0.008388939,
0.056920704,
-0.014414984,
0.023114135,
-0.008256935,
0.021094454,
-0.021860085,
-0.018942768,
0.010778236,
-0.008837758,
-0.027245903,
0.0061877505,
-0.00815793,
-0.0124811055,
0.023734562,
0.036327872,
-0.019391585,
-0.002498201,
-0.012738516,
0.004032763,
-0.009240374,
0.022889728,
-0.040208828,
-0.035694245,
-0.0013060279,
0.015523829,
0.0034123382,
-0.0035773448,
0.009279976,
0.016843881,
-0.0074979034,
0.010217214,
-0.027377909,
0.00030938754,
0.010567028,
-0.003262182,
0.00052719633,
-0.023404548,
0.0025526534,
0.0690652,
-0.015748238,
0.015088211,
-0.014494187,
-0.021846885,
-0.025292225,
-0.00788732,
-0.0047455924,
-0.0015469376,
0.0044584805,
-0.034030978,
0.016632674,
-0.014005767,
0.014150973,
0.02046083,
-0.012250097,
-0.014929805,
-0.003920559,
-0.03661828,
0.015576631,
-0.020276021,
0.021833684,
0.026836688,
-0.021437667,
0.0016929685,
-0.012725315,
-0.001431433,
-0.011682473,
-0.028724363,
0.025041414,
-0.03875677,
0.017160695,
0.009286576,
0.0025625539,
-0.01134586,
-0.013385342,
0.010626431,
-0.00033063215,
-0.00839554,
0.02002521,
-0.027958732,
-0.00045500594,
0.014216975,
-0.0048742974,
-0.044380195,
0.041106466,
-0.0035707445,
-0.010270016,
0.025305424,
-0.027377909,
-0.005633328,
-0.0008204957,
-0.010685833,
0.030783646,
-0.011279857,
-0.0007734688,
-0.014164174,
0.011510866,
0.004771993,
-0.01432258,
0.027245903,
0.024843406,
0.0043759774,
0.0020823844,
0.017160695,
-0.16527069,
0.0030641742,
0.010745235,
-0.033793367,
0.02835475,
-0.014441385,
0.018454347,
-0.011781477,
-0.014124572,
-0.0039568604,
0.006682771,
-0.01529942,
-0.011596669,
-0.009477984,
-0.00077635644,
-0.0070754867,
-0.049132388,
0.020606035,
0.017464308,
-0.005725732,
0.02122646,
-0.0035542438,
0.016896684,
-0.0014891853,
-0.0043594767,
0.023127336,
-0.027509915,
0.053778976,
-0.0017985728,
-0.023576155,
-0.02543743,
-0.0009529136,
0.025978653,
-0.0020394826,
-0.0087651545,
-0.009471384,
-0.026044656,
-0.0012078489,
0.0039799614,
0.010718834,
0.010798037,
0.02026282,
0.012520707,
0.0011995985,
-0.009537386,
0.008025925,
0.030044416,
-0.009616589,
0.015444625,
-0.0068972795,
0.01160327,
-0.019840404,
0.03363496,
0.0011195703,
-0.006943481,
0.008382339,
0.015603032,
0.01358335,
0.0139661655,
-0.005755433,
0.011893681,
-0.04023523,
0.020130815,
0.0013786309,
-0.023325345,
-0.038888775,
0.0050723054,
-0.01899557,
0.0042109704,
0.007062286,
-0.02397217,
-0.027113898,
0.010058807,
-0.0014231827,
0.03181329,
0.019946007,
0.0050459043,
0.01630266,
-0.0040690647,
-0.009510986,
-0.0002668983,
-0.010897041,
-0.0494228,
0.0038380555,
-0.0075441054,
0.0032044298,
-0.0029981714,
0.017332302,
0.00018583877,
-0.0022275902,
0.00086546,
-0.043746572,
-0.008520945,
-0.0113194585,
-0.011524066,
0.026097456,
-0.0062306523,
-0.00345194,
0.028196342,
-0.014150973,
-0.008276735,
0.004593786,
-0.004775293,
0.009365779,
-0.004243972,
-0.019959208,
-0.02002521,
-0.00050038274,
0.016342262,
-0.021648876,
-0.004577285,
0.0057917344,
0.00840214,
-0.019840404,
0.012243496,
0.025094217,
-0.011715475,
-0.0125273075,
0.0074187005,
0.009563787,
0.054439005,
-0.003923859,
-0.011147851,
-0.0048016943,
-0.016672276,
-0.004003062,
-0.1013801,
-0.02097565,
0.02618986,
-0.00765631,
0.019576393,
0.025305424,
-0.0030625241,
-0.0033001336,
-0.023272542,
0.018045131,
-0.035483036,
-0.031258866,
-0.016223457,
-0.0345854,
0.033476554,
-0.006550765,
0.008270135,
-0.038149543,
-0.01456019,
0.03387257,
0.0052538128,
-0.0077619143,
-0.0071480894,
-0.004719191,
-0.013649353,
-0.026242662,
-0.0020345324,
0.011398662,
0.0036466478,
0.024354987,
-0.00088278577,
0.0026615579,
-0.00018707632,
-0.010923442,
-0.016500669,
0.024170179,
-0.030308427,
-0.029780407,
0.021173658,
-0.036380675,
0.015207016,
0.026955491,
0.0222561,
0.0019437787,
0.016117852,
0.0016170655,
-0.021398067,
-0.020342024,
0.0059666415,
-0.028856369,
-0.007115088,
-0.009022566,
-0.008131529,
-0.020408027,
-0.0115042655,
-0.008831157,
0.009887201,
0.011781477,
0.0039634607,
0.018467547,
-0.0058115353,
0.017715117,
-0.033978175,
0.013596551,
0.031681284,
-0.0031301768,
-0.024011772,
-0.027562717,
0.016249858,
-0.012560309,
-0.025279025,
0.02149047,
0.0007532555,
0.002765512,
-0.029754005,
-0.0013786309,
0.0040228628,
0.0032011296,
-0.01875796,
-0.017319102,
-0.018150736,
-0.010085208,
0.008824557,
-0.00091496203,
-0.0057125315,
0.010138011,
0.019365184,
-0.021332065,
0.007854318,
-0.00070004084,
0.015867043,
0.021873286,
0.027826726,
-0.00091991224,
0.0011467964,
-0.007583707,
0.020130815,
-0.0020592834,
0.0006884904,
0.007365898,
-0.0048082946,
-0.0018794261,
-0.050769255,
0.023774162,
0.012111491,
-0.000469444,
0.012863921,
-0.014084971,
0.01285072,
-0.0007491303,
0.009411981,
0.0075507057,
-0.03653908,
0.0091149695,
-0.022770923,
0.017622713,
-0.033529356,
-0.024341786,
0.021292463,
0.00019450163,
0.022071294,
0.03279013,
-0.006392359,
0.009596788,
-0.016329061,
0.03902078,
0.016395064,
0.0028183141,
-0.006791675,
0.016408265,
0.004953501,
-0.006392359,
0.026612278,
-0.020856844,
-0.001359655,
0.007709112,
-0.01680428,
-0.025503432,
0.026255863,
0.014956206,
0.038228747,
0.020064812,
-0.0148242,
-0.0108310385,
0.0016756429,
-0.033714164,
-0.012474505,
-0.010771636,
-0.032710925,
0.026810287,
0.0112270545,
-0.017332302,
0.034664605,
0.009279976,
0.0016030399,
-0.014269778,
-0.027826726,
0.008375739,
-0.02835475,
0.0075639063,
-0.012448104,
-0.019946007,
0.033714164,
-0.025727842,
0.008355939,
-0.012520707,
0.036222268,
-0.022176899,
-0.0136889545,
-0.00034342016,
0.012395302,
0.0030328229,
-0.006943481,
-0.0017903225,
0.00006512608,
0.0014718596,
0.026559476,
0.009814598,
-0.01630266,
0.044591404,
-0.004300074,
0.038202345,
0.026783885,
0.0036862493,
-0.041872095,
0.028196342,
0.02493581,
-0.008204132,
-0.014401783,
0.005389118,
-0.025252623,
-0.028565956,
-0.019021971,
-0.0014099821,
-0.0038116544,
0.011187453,
0.015933046,
0.020289222,
-0.0048346957,
-0.0005387468,
0.012382101,
-0.0029734203,
-0.009801397,
-0.0013712056,
-0.00543202,
-0.03088925,
-0.007709112,
0.0030245725,
-0.009326178,
-0.0345326,
0.0052670133,
-0.014058569,
0.017860323,
0.008025925,
-0.0074121,
0.0055145235,
-0.000052699008,
-0.022335304,
-0.018414745,
0.03558864,
-0.040684048,
0.012778117,
-0.006857678,
0.0017705217,
0.017398305,
-0.012065289,
0.019114373,
0.0012127991,
0.016368663,
-0.020117614,
0.011240255,
-0.013886962,
0.018388344,
-0.021556472,
-0.03577345,
-0.008256935,
0.00915457,
-0.05010923,
0.019074772,
-0.00078130665,
0.013622952,
0.06246493,
-0.006204251,
-0.014863802,
-0.02174128,
0.0070952876,
0.011471265,
-0.0037621523,
-0.018625954,
-0.0026599078,
-0.005956741,
0.02843395,
-0.017728318,
0.010481224,
-0.049475603,
-0.025978653,
-0.007260294,
0.012329299,
-0.016896684,
0.0027556117,
0.008474743,
0.0028513155,
-0.032710925,
0.005960041,
0.003257232,
-0.0030757245,
0.0056135273,
0.019866804,
-0.00041746692,
-0.009946602,
-0.034242187,
0.008276735,
0.00814473,
-0.030730845,
-0.03508702,
0.021384867,
-0.014177375,
0.002838115,
-0.018216738,
0.00021388991,
0.0023117436,
0.007847718,
0.042136107,
-0.029014776,
0.0024519993,
-0.02343095,
-0.03263172,
0.0030229224,
-0.015919846,
-0.009616589
] |
BACKGROUND Circadian clocks control cell cycle factors, and circadian disruption promotes cancer. To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle progression and reduces proliferation, we compared growth and cell cycle events of B16 melanoma cells and tumors with either a functional or dysfunctional clock. RESULTS We found that clock genes were suppressed in B16 cells and tumors, but treatments inducing circadian rhythmicity, such as dexamethasone, forskolin and heat shock, triggered rhythmic clock and cell cycle gene expression, which resulted in fewer cells in S phase and more in G1 phase. Accordingly, B16 proliferation in | [
-0.03138737,
-0.0061075594,
0.009893845,
-0.023507081,
-0.03780934,
0.000755083,
-0.014797286,
-0.00028158826,
-0.02766798,
0.0013830645,
-0.004154211,
0.010857141,
0.024791474,
0.014449429,
-0.016228849,
0.028256662,
0.035053246,
-0.0076862937,
-0.01131203,
0.006950443,
-0.029112924,
0.021941725,
0.01665698,
-0.012971038,
-0.0052914345,
0.015212038,
0.005906873,
-0.028551001,
-0.0033029655,
-0.0017225592,
0.023279635,
-0.0010335356,
0.0031123133,
0.00937875,
-0.017165387,
-0.017941374,
0.016884426,
-0.030852206,
0.011519406,
-0.011700024,
0.005846667,
0.0067631355,
-0.011786988,
-0.009024204,
-0.023694389,
0.0214467,
0.050947618,
-0.015600032,
0.0025169433,
0.0033012931,
0.012917522,
0.016549949,
-0.032645006,
-0.003257811,
-0.016469674,
-0.019680658,
0.022998674,
0.022450132,
-0.012134844,
-0.005137575,
-0.0015578291,
-0.004147521,
-0.023159225,
0.035160277,
0.0069571324,
0.0042645885,
0.0035320828,
-0.0009106151,
0.01650981,
-0.004254554,
0.058279365,
0.021152359,
-0.031815503,
-0.0020938292,
-0.015693685,
-0.025821665,
-0.035775717,
0.01131203,
0.0134058595,
0.008194699,
0.012335531,
-0.014623357,
-0.023547217,
0.031922534,
0.003662529,
0.024644304,
-0.016416157,
-0.014181847,
0.005074024,
0.009305165,
0.0018647122,
-0.00080400036,
0.013078071,
0.014636736,
-0.012308773,
0.0021858106,
0.013064692,
0.028149629,
0.010897278,
-0.037862856,
0.011271893,
0.012282015,
-0.0060941805,
-0.017446348,
-0.028390452,
-0.020938294,
0.026905373,
-0.014369154,
0.011720092,
-0.01859695,
-0.034437805,
0.018944807,
-0.0034618424,
-0.03152116,
0.021928346,
0.0031390716,
0.009746675,
0.017165387,
-0.010783555,
-0.022664197,
0.02246351,
0.013653372,
0.044873506,
-0.014676874,
0.02409576,
-0.012569665,
0.012750283,
-0.0019684003,
-0.009519231,
-0.011592991,
-0.020577058,
0.013466065,
0.007204646,
0.0084489025,
-0.010763487,
-0.008435523,
0.003413343,
-0.00424452,
-0.029139683,
-0.009786813,
-0.012228498,
0.025848424,
-0.003192588,
-0.01116486,
0.005147609,
0.03735445,
0.018396264,
0.012670008,
-0.021379804,
0.006070767,
0.017780825,
-0.0052011255,
0.006739722,
0.0021306218,
0.007866912,
0.020496782,
-0.0011982657,
0.028524244,
-0.005100782,
-0.016161954,
0.023480322,
-0.0130713815,
0.03561517,
0.016442915,
0.033447754,
0.020028515,
0.012964349,
-0.006298212,
-0.014703632,
-0.007110992,
0.0013178415,
0.013646683,
-0.017673792,
0.032323908,
-0.023841558,
0.0339294,
-0.012228498,
0.029808637,
-0.028256662,
-0.011793678,
-0.042010378,
0.010435699,
0.016697118,
0.0075725713,
-0.0041876584,
-0.006191179,
0.022811368,
-0.005401812,
0.009278406,
-0.0049770256,
-0.026289934,
-0.011124723,
-0.009626263,
0.0033798954,
-0.6233591,
-0.012904143,
-0.007973944,
-0.003749493,
-0.0037762513,
0.023333153,
0.0046626166,
0.010335355,
-0.03510676,
0.013459376,
0.003413343,
0.007485607,
0.027801773,
-0.017459726,
-0.0029066098,
-0.048459105,
0.004863303,
-0.0031390716,
0.012335531,
0.0046960646,
-0.007679604,
0.0017961443,
0.0067497566,
0.026142763,
0.009659711,
0.022369856,
0.022262825,
0.0024283067,
0.015412725,
0.033554785,
-0.029969186,
0.015252175,
-0.00952592,
-0.01220843,
0.05999189,
0.008020771,
-0.0030270217,
0.018637087,
0.007485607,
0.049663223,
-0.009285096,
-0.011833815,
0.036123574,
0.019573625,
-0.03810368,
0.0011631456,
0.004880027,
-0.026289934,
0.009318544,
-0.005579085,
0.019319423,
0.01741959,
-0.023975348,
-0.00803415,
0.011706714,
-0.005094093,
0.01815544,
-0.024577409,
-0.003274535,
-0.00023706094,
0.008261595,
0.026022352,
-0.02322612,
0.004970336,
-0.02290502,
0.024189414,
-0.01695132,
0.006609276,
0.0073852637,
-0.01741959,
0.0029701605,
0.01384737,
-0.008154562,
0.012716835,
0.010094532,
0.025420291,
0.014329017,
-0.0047161332,
-0.014114952,
0.0117535405,
0.0003581,
-0.009572747,
-0.03366182,
0.0014248743,
0.015292312,
-0.009793502,
-0.008308422,
0.014904318,
-0.014543083,
0.0043649315,
0.010462457,
-0.004809787,
0.0065724836,
-0.031200064,
-0.009131236,
0.026530758,
-0.00069696753,
0.0074655386,
-0.010288529,
-0.018369505,
-0.013967781,
0.00047454,
0.0015126746,
0.0025319948,
0.021152359,
-0.006027285,
-0.027360262,
-0.0073919534,
0.04273285,
-0.02218255,
0.0022443442,
0.005639291,
-0.0016213797,
-0.003632426,
-0.0048432346,
-0.02038975,
0.035320826,
0.013499513,
0.016242228,
-0.018944807,
-0.0028547656,
-0.020791123,
0.0029367127,
-0.025848424,
0.030932482,
-0.000893055,
0.010556111,
-0.018623708,
-0.022115653,
-0.018128682,
0.0055088447,
-0.0075725713,
0.026249796,
-0.03184226,
0.021593869,
0.003752838,
0.017727308,
-0.017834341,
0.009265027,
-0.02097843,
-0.022450132,
0.0024584099,
0.004558929,
0.014262122,
0.008729863,
0.0018145406,
-0.039628897,
0.009325233,
0.010248391,
0.005475397,
0.005819909,
-0.029407265,
-0.020643953,
0.0014533049,
0.025406912,
-0.0061410074,
-0.011111343,
-0.012462633,
-0.009659711,
-0.00684341,
0.025059056,
-0.0020001756,
-0.017459726,
-0.0036859424,
-0.014757148,
0.004374966,
0.00013420911,
-0.009291786,
0.010763487,
-0.038826153,
-0.011847194,
-0.00468603,
-0.010435699,
0.008321801,
0.021834692,
0.007800016,
-0.031039514,
-0.016590085,
-0.023480322,
-0.0014900974,
0.0095660575,
-0.010134669,
-0.025059056,
-0.00878338,
0.04270609,
0.028738309,
0.033099897,
-0.021660764,
-0.011786988,
0.02798908,
-0.007318368,
0.0108838985,
-0.004344863,
0.0028547656,
0.014783907,
-0.041261148,
0.0015678634,
0.0055590165,
0.02128615,
0.027186334,
0.003261156,
-0.040565435,
0.011398994,
-0.037300933,
0.011071206,
-0.011860573,
0.014021298,
0.0023931868,
0.0047228225,
0.021955105,
-0.0033280514,
0.010208254,
-0.012536217,
-0.0030872275,
-0.00070532947,
-0.00058784423,
-0.021687523,
-0.0042512096,
-0.016268987,
-0.0073116785,
-0.016135195,
0.002812956,
0.0100343255,
-0.0024216173,
0.0034417738,
0.0137403365,
0.01799489,
0.017459726,
0.0193328,
0.009706538,
-0.0003658348,
0.014984593,
-0.007860222,
0.013646683,
0.016175333,
0.009124547,
-0.00003342162,
-0.0036658738,
0.0476296,
0.018998323,
-0.00075382873,
0.0040873154,
0.016483052,
0.0037461482,
0.0000015466319,
-0.0008391205,
0.017285798,
0.00072539813,
-0.007452159,
-0.008810138,
-0.016924562,
-0.017459726,
-0.034143467,
-0.007157819,
0.014690253,
-0.02277123,
0.00011529022,
0.0028581105,
0.03561517,
0.019252526,
0.012817179,
0.008810138,
0.011847194,
-0.029567814,
-0.0122887045,
-0.0020419853,
0.019145494,
0.0021925003,
-0.017700551,
0.018436402,
-0.015733823,
0.018998323,
0.019774312,
-0.04629169,
0.021179117,
0.017299177,
-0.0025620977,
0.009405508,
0.023908453,
0.007425401,
-0.004211072,
-0.00773981,
0.0076260874,
0.017887859,
0.008903792,
0.00014298914,
-0.034919452,
0.007800016,
0.01653657,
-0.0035789094,
-0.023306394,
0.020470025,
-0.014944456,
-0.012335531,
-0.009579436,
-0.001372194,
0.008007392,
-0.0013487806,
0.021232633,
0.0044151032,
-0.00080650894,
0.019961618,
-0.017901238,
-0.0046492377,
0.022209307,
0.012362289,
0.0056426357,
-0.00610087,
-0.007779947,
-0.020884776,
0.013024555,
-0.0077866367,
0.0011430769,
-0.007947186,
0.002230965,
0.015533136,
0.01369351,
-0.00804084,
0.009512541,
0.0059169075,
-0.009746675,
-0.0017844376,
-0.017901238,
-0.01547962,
0.023440184,
0.020643953,
0.011786988,
0.010127979,
0.010348734,
0.0075190547,
-0.010168117,
-0.03082545,
0.02083126,
-0.028738309,
-0.0012266963,
-0.0103688035,
-0.0076528457,
0.013559719,
-0.0072380938,
0.025099194,
-0.007833464,
-0.0040404885,
-0.008208078,
0.03403643,
0.00082741375,
-0.004699409,
0.031708468,
0.049689982,
0.023306394,
-0.0056158775,
-0.0012501098,
0.021179117,
0.0063316594,
-0.02991567,
-0.026129384,
0.01564017,
0.0005941157,
0.03275204,
0.019934861,
-0.029407265,
0.016616844,
0.011024379,
0.005298124,
-0.0011698351,
0.015733823,
0.007907049,
0.004435172,
-0.020041894,
0.013231931,
-0.018690605,
0.027213091,
0.0015603376,
-0.022302961,
-0.016563326,
0.006070767,
-0.0044886884,
-0.003132382,
-0.016590085,
0.033474512,
0.008823517,
-0.00833518,
0.005150954,
-0.016897805,
0.027119437,
0.009545988,
-0.019265905,
0.012094707,
0.007204646,
0.006485519,
0.0128037995,
0.0052479524,
-0.021593869,
-0.022262825,
0.0050974376,
0.009024204,
-0.033367477,
-0.0066594477,
0.013312206,
0.039789446,
0.011813746,
0.026985647,
-0.012690078,
-0.007679604,
-0.011766919,
0.008000703,
-0.020055272,
0.0044151032,
-0.026945509,
-0.021031946,
0.006950443,
0.022008622,
-0.022142412,
-0.02010879,
0.004869993,
-0.0017058353,
0.00061752915,
0.030397318,
-0.019078597,
-0.014114952,
0.010643075,
0.019587005,
0.022717714,
0.009104478,
0.0042311405,
0.01473039,
-0.01815544,
-0.020577058,
0.0066895504,
-0.0051175063,
-0.01473039,
0.012984417,
0.020175684,
-0.02141994,
-0.0022844814,
0.010295218,
-0.010395561,
-0.01369351,
-0.0064955535,
0.007191267,
0.01725904,
-0.032350667,
0.021259392,
-0.0015804063,
-0.0030671589,
-0.0096664,
-0.00095409714,
0.025353396,
-0.024189414,
-0.026972268,
0.002769474,
-0.0035688751,
-0.014837423,
-0.028015837,
-0.015533136,
-0.008201389,
0.014957835,
-0.017593518,
-0.057530135,
-0.019774312,
-0.0034718767,
-0.0019132114,
-0.002001848,
-0.01086383,
-0.0018563502,
-0.030745175,
0.00580653,
0.017058354,
-0.046024106,
0.008709795,
-0.03735445,
-0.0050205076,
-0.0023714458,
0.031574678,
-0.0006576664,
-0.009271717,
-0.011338788,
-0.032404184,
-0.009619574,
-0.0072581624,
-0.042920157,
-0.009398818,
-0.017192144,
0.039227523,
0.031708468,
0.026999027,
-0.008609451,
-0.0058132196,
0.0306649,
0.009218201,
-0.0068367207,
-0.003930111,
0.020791123,
-0.021914968,
0.01323862,
-0.005207815,
0.011271893,
0.008810138,
0.006234661,
0.011332098,
0.013017865,
-0.004642548,
-0.012328842,
-0.01828923,
-0.015385966,
-0.04613114,
0.01547962,
-0.004970336,
-0.004180969,
-0.01755338,
-0.019921482,
0.02635683,
0.019172251,
0.012174982,
-0.024684442,
0.008562624,
-0.026945509,
0.027146196,
-0.029514296,
0.01683091,
-0.025246363,
-0.021312907,
-0.0077063623,
0.007050786,
0.03004946,
-0.012703456,
-0.0019048495,
0.014957835,
-0.03200281,
0.009392129,
0.0007099286,
-0.010482525,
-0.02038975,
-0.01637602,
-0.02753419,
-0.023921832,
0.00032047127,
-0.02319936,
-0.0022510337,
-0.010462457,
0.010342045,
-0.0419301,
0.008997445,
-0.0011539474,
0.011492648,
0.035320826,
-0.020322854,
0.028898858,
-0.025166089,
0.031949293,
0.01576058,
-0.0064353477,
-0.0011230083,
-0.030477593,
-0.016416157,
0.0033982918,
0.018436402,
0.026597653,
-0.010509284,
0.008161251,
0.019520108,
0.031735227,
-0.01771393,
-0.018208956,
0.002916644,
0.010255081,
-0.0025804942,
-0.010208254,
-0.040511917,
-0.023774663,
-0.021834692,
-0.018944807,
0.028229903,
-0.007800016,
-0.019132115,
-0.017044974,
0.037568517,
-0.0205503,
0.0046157897,
-0.0068969266,
-0.004227796,
-0.009178063,
-0.00249353,
-0.012335531,
-0.012174982,
-0.013144967,
0.017660413,
-0.012389047,
0.002062054,
0.009994188,
-0.0032243633,
-0.000396983,
-0.0134058595,
-0.014864181,
0.04300043,
-0.015720444,
0.005850012,
0.0068032728,
-0.0022727747,
0.026851855,
0.00031357267,
-0.011184928,
0.0003131546,
-0.015653549,
0.009271717,
0.027962321,
0.018530054,
-0.02647724,
0.016937941,
-0.003823078,
-0.008689726,
-0.034304015,
-0.015131763,
0.021232633,
-0.036551703,
0.014409292,
-0.00022556329,
0.027293365,
0.025500566,
0.013780474,
-0.016469674,
0.010917346,
0.026731445,
-0.014623357,
0.036685497,
0.0033631716,
0.00050422485,
-0.030905724,
0.0067664804,
-0.009131236,
-0.048619654,
0.0061811446,
-0.026825098,
-0.042813122,
-0.012415806,
-0.0054653627,
0.011860573,
-0.007973944,
-0.014997972,
0.021018568,
0.020122169,
0.013298826,
0.0034651873,
-0.035641924,
-0.010449078,
-0.01384737,
-0.0023112397,
0.021781176,
-0.01605492,
-0.009298475,
0.0052145044,
0.0070641655,
0.0059537,
0.0080475295,
0.012248567,
-0.021526974,
0.0005301469,
-0.01428888,
0.0037160453,
-0.02453727,
-0.014382534,
-0.01800827,
0.020349612,
-0.0007488116,
-0.0022811368,
-0.01756676,
-0.013700199,
0.015212038,
0.04008379,
-0.016121816,
0.0048566135,
0.00009516931,
-0.033849124,
-0.030691657,
-0.013512892,
0.008295042,
0.03451808,
0.016041541,
-0.008749932,
-0.015693685,
-0.026276555,
-0.023921832,
-0.036364395,
0.028845342,
0.019239148,
0.0079137385,
0.008174631,
0.0056627044,
0.0196539,
-0.008662968,
0.021981863,
0.012897453,
-0.028658034,
-0.0051074717,
-0.019667279,
0.01964052,
-0.005207815,
-0.00036813432,
0.019867964,
0.026463863,
-0.015573273,
-0.024189414,
0.0029701605,
0.009351992,
-0.0037561825,
-0.0072581624,
0.00035078332,
0.00032381606,
0.008154562,
0.0063182805,
-0.008622831,
-0.008529177,
0.0039368006,
-0.0013822283,
-0.018409643,
0.008863654,
-0.009653022,
-0.0037327693,
0.005890149,
-0.026450483,
-0.032859072,
0.013526271,
-0.013519581,
0.012482701,
0.02246351,
0.037755825,
0.009037583,
0.012743594,
-0.009572747,
-0.011700024,
0.0036926318,
-0.009492472,
-0.013051313,
0.018476538,
-0.00729161,
-0.022704335,
0.0093653705,
0.027775014,
-0.012362289,
-0.007860222,
-0.015894372,
0.0009390456,
-0.018583572,
0.025527325,
-0.00758595,
-0.0056493254,
-0.008649589,
0.003913387,
-0.017138628,
-0.019145494,
-0.017218903,
0.0039568692,
-0.016228849,
0.005850012,
-0.013251999,
0.0060473536,
0.026611032,
-0.010529352,
0.0070374073,
-0.0014106589,
-0.008529177,
0.18955511,
-0.011720092,
-0.01205457,
0.014663495,
-0.006605931,
0.00034931998,
0.02068409,
-0.002149018,
-0.0056426357,
0.026276555,
0.010375493,
-0.0029584537,
-0.011987674,
0.0038598706,
0.013967781,
-0.0018479883,
-0.02635683,
0.009244959,
-0.012616492,
-0.018583572,
0.021513594,
-0.029193198,
-0.014650116,
-0.014422671,
0.029139683,
0.0007626088,
-0.026611032,
-0.0057764268,
0.029808637,
0.007773258,
-0.03778258,
0.008997445,
-0.002480151,
-0.018944807,
-0.013713579,
0.0051977807,
-0.0031608127,
-0.031307098,
0.0102350125,
-0.015305691,
-0.005967079,
-0.004512102,
-0.020269338,
0.007231404,
0.022035379,
0.005418536,
-0.00022012801,
0.008877033,
0.007779947,
-0.010154738,
-0.05078707,
-0.0057061864,
0.032859072,
0.03128034,
0.0006367616,
-0.009157995,
0.024938645,
-0.0028698172,
-0.003378223,
0.03050435,
-0.014797286,
-0.009793502,
-0.016282367,
0.013185104,
-0.009599505,
-0.0025905285,
-0.020162305,
0.021834692,
0.0124224955,
-0.013981161,
-0.006130973,
-0.011532785,
-0.025835045,
-0.0056928075,
0.018142061,
-0.012516149,
0.023881696,
0.018021649,
0.0102350125,
0.02588856,
0.012134844,
-0.012302083,
-0.023507081,
-0.006371797,
-0.0009064341,
-0.025125952,
0.026463863,
0.021674143,
-0.014181847,
-0.022998674,
0.0021557077,
-0.009653022,
0.0058834595,
-0.023386668,
0.0034952902,
-0.018784259,
0.014663495,
0.0045321705,
0.011251824,
-0.03601654,
-0.035347585,
0.053757228,
0.008669658,
0.007378574,
0.0031290373,
-0.009405508,
-0.010817003,
0.0061510415,
0.02247689,
-0.010449078,
-0.0045890315,
-0.014717011,
0.01934618,
-0.012910833,
0.00016284875,
0.031574678,
0.020483404,
-0.038050164,
0.012255256,
-0.018530054,
-0.0042077275,
-0.036685497,
0.00043774745,
0.03676577,
-0.007820085,
-0.014302259,
-0.014382534,
-0.012676698,
0.0008148709,
-0.03408995,
0.010255081,
-0.0202292,
-0.015064868,
0.0054687075,
0.012014433,
-0.026503999,
0.030290285,
-0.013981161,
0.018877912,
0.013820611,
-0.0023413426,
0.008622831,
-0.018208956,
0.029728362,
-0.012455943,
-0.026008973,
0.005699497,
-0.0042344853,
-0.031307098,
-0.035374343,
-0.0004042997,
-0.031601436,
0.007987323,
-0.0024868404,
0.023747904,
-0.032216877,
-0.013767095,
-0.04316098,
0.015533136,
0.018717362,
-0.0054653627,
0.012710146,
0.008308422,
-0.012108087,
0.011091275,
0.0041341423,
-0.16739932,
0.004997094,
0.03676577,
-0.01799489,
0.012389047,
0.011332098,
-0.0014524687,
-0.012248567,
-0.016242228,
0.010321977,
0.019025082,
0.019319423,
-0.02500554,
-0.007231404,
0.0143423965,
0.0017727308,
-0.025473809,
0.031708468,
0.018877912,
0.013506202,
0.0075190547,
-0.032350667,
0.021112222,
-0.010616316,
-0.01652319,
0.01502473,
0.01458322,
-0.0063149356,
-0.010181496,
-0.016014785,
-0.029139683,
0.008341869,
-0.005803185,
-0.0016932925,
0.011847194,
-0.010007568,
-0.013064692,
0.007425401,
0.0055723954,
0.0065256567,
0.033742093,
0.013666752,
0.011786988,
0.018436402,
-0.014355775,
0.03855857,
0.008596072,
0.0025403567,
0.0066862055,
-0.014783907,
0.044258066,
-0.005592464,
0.005003784,
0.0049168197,
-0.00543526,
0.018369505,
0.002053692,
0.008816828,
0.011332098,
-0.012703456,
-0.0019316077,
-0.021674143,
0.027480673,
0.010937415,
-0.012870695,
-0.037916373,
-0.0105025945,
0.013011176,
-0.014931077,
0.009847018,
-0.02440348,
0.014382534,
0.018958187,
-0.025246363,
0.02546043,
-0.0035855991,
-0.0014248743,
0.008950619,
-0.0012777041,
0.0125562865,
-0.010823693,
0.013680131,
-0.0321366,
-0.017138628,
-0.005997182,
0.015573273,
0.022008622,
0.04990405,
-0.005043921,
0.010770177,
0.025861802,
-0.0073049893,
0.00610087,
-0.017178766,
0.020028515,
0.027266609,
0.00803415,
-0.022022,
0.0084489025,
-0.01206126,
0.015372587,
-0.019172251,
-0.021219254,
0.023587355,
0.036819287,
0.0071711983,
-0.004880027,
-0.01159968,
0.03944159,
-0.01830261,
-0.02188821,
0.012221809,
-0.0022359823,
0.0008796759,
-0.009305165,
0.039682414,
0.006789894,
0.00094908,
-0.004629169,
-0.017299177,
0.07545813,
0.02647724,
-0.014382534,
0.02529988,
0.0011656542,
-0.010041015,
-0.14278176,
-0.027065922,
0.0057797716,
0.009947361,
-0.013345653,
0.030183252,
-0.016630223,
0.008743242,
-0.014128331,
0.036417913,
-0.019279284,
-0.007833464,
-0.005181057,
0.0078468425,
0.008208078,
-0.03138737,
0.026450483,
-0.009693159,
-0.0018513331,
0.029407265,
0.004776339,
0.01756676,
-0.012476012,
-0.017446348,
0.005344951,
0.008696415,
-0.029353747,
0.004435172,
0.009238269,
0.019426454,
0.0012250239,
0.011118033,
-0.0031223476,
0.007231404,
-0.029567814,
0.00624804,
-0.011967606,
-0.036953077,
0.030156493,
-0.026437104,
-0.0039936616,
0.02991567,
0.019921482,
0.016001405,
0.017245661,
-0.017968133,
-0.019118736,
0.008970687,
0.02009541,
-0.015265554,
-0.026263176,
-0.005726255,
-0.0022108965,
-0.014128331,
0.017352695,
-0.03944159,
0.009325233,
0.018543433,
-0.011372236,
-0.012308773,
-0.009117858,
0.009485783,
-0.0011062844,
0.00016107183,
0.002075433,
-0.02319936,
-0.028604519,
0.0034685319,
0.01755338,
-0.0024065657,
-0.008843586,
-0.0039200764,
-0.023761284,
-0.000006846337,
-0.03390264,
-0.0023764628,
-0.0178611,
-0.008321801,
0.00040220923,
-0.015198659,
-0.0014073142,
-0.0031340544,
0.042625815,
-0.010208254,
0.024644304,
-0.007371885,
0.006294867,
-0.0035220482,
-0.008569314,
0.011024379,
-0.01027515,
0.025366776,
0.0076528457,
-0.010475836,
-0.024015486,
0.0068400656,
0.0046258243,
0.028229903,
0.02633007,
0.019867964,
-0.018423023,
-0.022557164,
-0.043829937,
0.019239148,
0.0029651432,
0.00023727,
0.007853532,
-0.008756622,
0.0075725713,
0.0032327252,
0.025219606,
0.008020771,
0.0072514727,
0.0006208739,
-0.007646156,
-0.022396615,
-0.026289934,
-0.017780825,
0.02113898,
-0.028470727,
0.0015904406,
0.041742794,
-0.0053750537,
0.008462281,
0.0055021555,
0.02187483,
0.004184314,
-0.007157819,
0.011633128,
0.023185981,
-0.011693334,
-0.012569665,
0.034625113,
-0.033126652,
-0.024456996,
-0.005150954,
-0.0052512973,
-0.025781527,
-0.013412549,
0.045194604,
0.014048056,
0.036123574,
0.0046057557,
-0.021914968,
0.022022,
-0.0066259997,
0.0075391233,
0.0042645885,
-0.034464564,
0.0089639975,
-0.0011146463,
-0.015385966,
0.007853532,
0.00602394,
-0.0020587093,
-0.0072113355,
0.0035956334,
-0.0015929493,
-0.025942076,
-0.025259743,
-0.014221984,
-0.028015837,
-0.009465714,
0.04286664,
0.0072514727,
0.0072514727,
-0.011894021,
-0.014824044,
-0.042946916,
-0.017366074,
-0.010602938,
-0.011225066,
-0.027882047,
0.0011673266,
0.031173306,
-0.013024555,
-0.0016464656,
0.0017275764,
-0.033608302,
-0.003421705,
0.003809699,
0.02412252,
0.016483052,
0.0026306657,
-0.02083126,
0.014770527,
0.03154792,
0.007157819,
0.00034785664,
0.015252175,
0.021353045,
-0.0048164763,
-0.004388345,
0.0021339667,
0.030317042,
-0.009913914,
0.015733823,
0.030236768,
-0.016255608,
0.010770177,
0.01414171,
0.027641222,
0.0069303745,
-0.018423023,
0.0017192145,
-0.009325233,
-0.006338349,
0.041582245,
-0.014690253,
-0.03663198,
-0.011492648,
-0.00019044314,
-0.0025620977,
-0.0025604255,
0.0078067053,
0.004388345,
-0.010007568,
0.017580139,
0.012482701,
0.023707766,
0.0055121896,
0.0029400575,
0.008576004,
0.009291786,
0.018249094,
0.017044974,
-0.0030019358,
-0.007318368,
0.007893669,
-0.019988377,
0.028042596,
-0.013954402,
0.039655656,
0.0029199887,
-0.047843665,
-0.018075166,
-0.00997412,
-0.033447754,
0.017914616,
0.024684442,
-0.031494405,
0.0838602,
0.003839802,
-0.021219254,
0.015038109,
-0.030932482,
0.0140748145,
0.0025788217,
-0.0016105092,
-0.047067676,
-0.02365425,
0.023440184,
-0.015720444,
0.010429009,
-0.043080706,
-0.028845342,
0.03494621,
0.016268987,
-0.0074454695,
0.028845342,
-0.0010970862,
0.028765067,
-0.013726958,
0.0031006066,
0.020871397,
-0.027935563,
-0.026985647,
0.0034785662,
0.009927293,
-0.01592113,
-0.021794556,
0.015038109,
-0.024644304,
-0.014717011,
0.0043047257,
0.008957308,
-0.010609627,
-0.01918563,
-0.031895775,
0.023573976,
0.030557867,
-0.03510676,
0.004806442,
-0.021299528,
-0.0068567893,
0.007907049,
-0.011265203,
-0.000975002,
0.0052747107,
-0.017071733
] |
Cytoplasmic dynein is a microtubule-based motor protein that is responsible for most intracellular retrograde transports along microtubule filaments. The motor domain of dynein contains six tandemly linked AAA (ATPases associated with diverse cellular activities) modules, with the first four containing predicted nucleotide-binding/hydrolysis sites (P1-P4). To dissect the functions of these multiple nucleotide-binding/hydrolysis sites, we expressed and purified Dictyostelium dynein motor domains in which mutations were introduced to block nucleotide binding at each of the four AAA modules, and | [
-0.031103028,
-0.018632473,
-0.007615707,
-0.0027942043,
-0.0335838,
0.033450425,
-0.0033527117,
0.018472424,
-0.00871605,
-0.011770335,
0.019712811,
0.031636525,
0.024194207,
0.005244968,
-0.009449611,
-0.006095233,
0.013684265,
0.0050349026,
0.0042813346,
0.0032776883,
-0.022967158,
0.010956748,
-0.016965287,
-0.03491755,
0.0011928718,
0.01131686,
-0.0068421327,
-0.023300596,
0.0049715494,
-0.019939547,
-0.0047481465,
-0.01695195,
0.015151389,
-0.010756685,
0.009456281,
-0.013210784,
0.0059818644,
0.007035526,
0.006598723,
0.00619193,
0.009542975,
0.01275731,
-0.013650921,
-0.0075556883,
-0.019899536,
0.004614772,
0.0069421637,
-0.0055283895,
0.003587785,
-0.00690882,
0.009916424,
0.020272985,
0.00028717282,
-0.01620505,
-0.015311439,
-0.020126272,
-0.0011086789,
0.007428982,
0.0001216004,
-0.015484826,
-0.0151113765,
0.015258089,
0.00011514005,
0.011103461,
-0.008569337,
-0.0055017145,
0.030329453,
0.0027325184,
0.0033610475,
0.0003499007,
0.033397075,
0.0070688697,
0.012197135,
0.0015404801,
0.046787914,
-0.03979907,
-0.0348642,
-0.0128640095,
-0.014657902,
0.029182428,
0.015298101,
-0.019832848,
-0.0028842322,
0.025061144,
-0.0011770335,
-0.01376429,
-0.013844315,
0.01445784,
-0.014257777,
-0.009169525,
0.014564539,
0.035531074,
0.0052382993,
0.013210784,
-0.0053283274,
0.01673855,
0.0038078534,
0.022140233,
-0.037558373,
-0.014924652,
-0.0037011534,
0.00060143747,
-0.017085325,
-0.02061976,
0.0052049556,
0.0053216587,
0.0035244317,
-0.020126272,
0.013750953,
-0.016725212,
-0.02562132,
0.019779498,
0.0149113145,
-0.061565854,
0.020006236,
-0.005781802,
0.0166852,
0.008549331,
-0.011390217,
-0.017445438,
0.00031947458,
0.05532391,
0.030782927,
-0.011310192,
0.04729474,
0.015751576,
-0.015044689,
-0.003921222,
0.01020318,
0.007949145,
-0.0037344974,
0.013050734,
-0.00096363365,
0.011203492,
-0.0101631675,
-0.0058418205,
-0.02274042,
-0.010296542,
-0.009542975,
-0.009389593,
0.0014121068,
0.025181182,
-0.028088754,
-0.006982176,
0.00009325823,
0.0003251013,
0.02790203,
0.011070116,
0.006121908,
0.028035404,
0.018925898,
-0.017592149,
-0.0019639453,
-0.009402931,
0.0036411348,
0.039639022,
0.0032160024,
0.004278,
-0.010883392,
-0.00002132175,
-0.026048118,
0.006381989,
0.029395828,
-0.0329436,
0.03449075,
0.022673734,
0.0017472112,
0.0032643508,
-0.022487009,
-0.022967158,
-0.009156187,
-0.008122532,
-0.0333704,
0.021993522,
-0.014097727,
-0.0031826587,
0.032756876,
0.013464197,
-0.03670477,
-0.011083454,
-0.002515784,
-0.0053983494,
0.013597571,
-0.0074689947,
-0.004034591,
-0.0111301355,
0.025287881,
-0.015044689,
0.0147112515,
-0.01046993,
0.0006418667,
-0.011563604,
-0.0020239642,
-0.010976754,
-0.62696874,
-0.021193272,
0.012150453,
-0.03825192,
-0.026474917,
0.023447307,
-0.0038778752,
0.015698226,
0.004951543,
0.018525774,
-0.021620072,
0.0149113145,
-0.0024557654,
-0.026021443,
-0.02316722,
-0.015258089,
-0.0011195156,
-0.0036277974,
0.036891498,
-0.0040212534,
-0.014697914,
0.014724589,
-0.02279377,
-0.0016171706,
0.008696044,
0.0045780935,
0.032756876,
-0.013110753,
-0.016618513,
0.029502528,
-0.009816392,
0.019939547,
-0.013897665,
0.004654784,
0.04462724,
-0.0013695935,
-0.008142537,
0.032436777,
0.0008744392,
0.023313932,
-0.018365724,
-0.0052316305,
0.010569961,
0.014978002,
-0.00903615,
0.017245375,
0.01296404,
-0.011663635,
-0.0005926847,
-0.01620505,
0.009522968,
0.003981241,
-0.018565787,
-0.0013754286,
-0.012470554,
0.0052382993,
0.014071052,
-0.0173254,
0.012823997,
0.014324465,
0.0088560935,
0.01360424,
0.0008252572,
-0.01837906,
0.0022173577,
0.0020606422,
-0.032223377,
0.015458151,
-0.015818262,
0.00690882,
0.011736992,
0.0075023384,
-0.00011482745,
0.030889627,
0.014751264,
0.030249428,
0.008669369,
0.025301218,
-0.009329574,
0.019646123,
0.007742413,
0.008122532,
-0.009703024,
-0.0036444692,
0.03819857,
0.0155381765,
-0.02562132,
0.030702902,
0.008009163,
-0.0036011224,
0.0102498615,
-0.010910067,
-0.011923716,
-0.043960366,
-0.025527956,
0.02242032,
-0.017232038,
0.0039512315,
0.0013904334,
-0.013697603,
-0.0074356506,
-0.012797322,
0.016285075,
-0.019245999,
0.018472424,
0.0008977798,
-0.028115429,
0.030436153,
0.023393957,
-0.018779187,
-0.006738767,
-0.009229544,
-0.0039945785,
-0.015924964,
-0.014284452,
-0.023407295,
0.017618824,
0.021233285,
0.014217764,
-0.03363715,
-0.0060785613,
-0.017338738,
0.005234965,
0.016565163,
-0.0029425838,
0.012890684,
0.018392399,
-0.03609125,
-0.005051574,
-0.0009369587,
-0.019659461,
-0.0024324248,
0.029902654,
-0.006265286,
0.029102404,
0.04006582,
0.026341543,
0.010296542,
-0.019819511,
-0.02694173,
-0.03427735,
-0.015924964,
-0.014377815,
-0.0029309134,
0.008696044,
-0.017031975,
-0.031369776,
-0.0069421637,
0.016458463,
0.0065120296,
-0.019912872,
0.004931537,
-0.00361446,
0.034197323,
-0.00046639537,
-0.010890061,
-0.026981743,
-0.009262887,
0.007248926,
-0.0144845145,
0.010329886,
-0.008956125,
-0.014844626,
0.02864893,
-0.010883392,
-0.027501905,
0.0072622634,
0.010990092,
-0.02268707,
-0.04209312,
0.015738238,
0.0019739484,
-0.027715305,
0.024260895,
0.00074564904,
0.016858587,
0.020126272,
0.00860935,
-0.0060252114,
-0.018085636,
-0.006208602,
-0.009556312,
-0.0013270803,
-0.018085636,
0.028995704,
0.02592808,
0.029342478,
0.005918511,
-0.010870054,
0.01912596,
-0.013584234,
-0.0066787484,
0.009269556,
-0.0038945472,
-0.009476286,
-0.021726772,
0.031289753,
0.014511189,
0.00019693638,
0.02029966,
0.012637272,
-0.02380742,
-0.012870678,
-0.020913184,
-0.007062201,
0.0019872861,
-0.008329263,
-0.027088443,
0.012630603,
0.011803679,
-0.0012603928,
-0.0076490506,
-0.0027358527,
-0.003947897,
-0.0024590997,
0.02375407,
0.001862247,
0.0074356506,
-0.00048931915,
-0.010843379,
-0.010723342,
-0.0050148964,
0.02146002,
0.008956125,
-0.0019139298,
-0.012217141,
-0.0044813966,
0.022206921,
-0.008742725,
-0.010996761,
0.002944251,
0.012503897,
0.018739173,
0.025861394,
-0.0008652697,
0.017258713,
-0.0163651,
0.013144096,
0.045560867,
0.0032693523,
-0.0047514807,
-0.00082067243,
0.0024024155,
0.005968527,
-0.010343224,
0.004494734,
0.02598143,
0.008796074,
0.0031076353,
0.0003772009,
0.00013222871,
0.021246621,
-0.029422503,
-0.014364477,
-0.031369776,
-0.0053816773,
0.013110753,
0.0116703035,
0.04782824,
0.015644876,
0.0058351518,
0.006775445,
0.010863386,
-0.01949941,
0.008749394,
-0.0076490506,
0.022460334,
0.006111905,
0.0100497985,
-0.0074556572,
-0.030969651,
0.017765537,
0.0317699,
-0.02587473,
0.033450425,
0.020259647,
0.0045880964,
-0.008669369,
0.018712498,
0.017565474,
-0.018979248,
-0.049081963,
0.005291649,
0.011203492,
-0.02109991,
-0.021780122,
-0.015098039,
0.019819511,
0.009409599,
0.010850049,
-0.006665411,
0.0024590997,
0.016778562,
0.025434595,
-0.0065653794,
-0.008896106,
0.019966222,
-0.02560798,
0.010763355,
-0.012250485,
0.007942475,
-0.009929761,
-0.026915055,
0.032116678,
0.048815213,
0.017205363,
0.00015619451,
-0.0023007172,
-0.00050223985,
-0.026821693,
0.0018122315,
-0.0048748525,
0.004187972,
-0.012270491,
-0.009122843,
-0.0018339049,
-0.008736056,
-0.007202245,
0.04537414,
-0.007942475,
-0.03385055,
-0.025914744,
0.0044613904,
-0.0053550024,
0.031449802,
0.023367282,
0.002479106,
0.014631227,
-0.023007171,
0.02423422,
-0.01440449,
-0.027768655,
0.039452296,
-0.017258713,
0.012090435,
-0.016871925,
0.0051049246,
0.0006456179,
0.007942475,
0.028728954,
-0.0063586487,
-0.008009163,
0.0011603617,
0.016045,
0.019219324,
0.009209537,
0.017312063,
0.023500659,
0.011843692,
-0.012377191,
0.00443805,
0.008415956,
0.0068221265,
-0.018138986,
0.0054450305,
0.002829215,
0.008849424,
0.0085426625,
-0.030222753,
-0.041906394,
-0.0008761064,
0.03449075,
-0.0074089756,
0.007849113,
0.017152013,
-0.00022277776,
-0.003214335,
-0.018845873,
0.011970397,
-0.0038545346,
0.0054283584,
0.0018289033,
-0.0002298633,
-0.004087941,
0.041959744,
-0.0179656,
-0.015911626,
-0.014257777,
0.003140979,
-0.012817328,
0.015071364,
0.0099364305,
-0.007248926,
-0.03192995,
0.015644876,
-0.010156499,
0.0030542852,
-0.01079003,
0.012417204,
-0.005054909,
-0.016991962,
-0.017071987,
-0.026501592,
-0.009122843,
0.0063253045,
-0.043960366,
-0.0329436,
-0.0021073234,
0.0013104085,
0.012623934,
0.0030459494,
-0.018792523,
-0.0004955711,
0.023834094,
-0.013590902,
0.0015954972,
-0.004187972,
-0.028088754,
-0.021620072,
0.012410535,
0.005541727,
0.009062825,
-0.0027358527,
-0.014671239,
0.032383427,
-0.012924028,
0.013010722,
-0.0046414468,
-0.0021540048,
-0.0015721567,
0.03342375,
0.038491998,
-0.023193896,
-0.00039866593,
0.0035911193,
-0.0337972,
0.0046214405,
-0.033610474,
0.009783049,
-0.026594955,
-0.005365005,
0.009542975,
0.0020523062,
-0.02093986,
-0.012083766,
-0.009156187,
0.0009878079,
-0.014697914,
0.022300284,
0.024474295,
-0.005478374,
0.014137739,
-0.026421567,
0.0031826587,
0.002972593,
-0.014364477,
0.019966222,
0.009876411,
-0.016298413,
0.022993833,
-0.008796074,
-0.026208168,
-0.015724901,
0.0051416024,
-0.009542975,
0.030676227,
-0.008522656,
-0.030196078,
-0.005781802,
-0.0049815527,
-0.020646434,
-0.020499723,
-0.00027508574,
-0.009176193,
0.0037078222,
-0.009449611,
0.006982176,
-0.00044680593,
0.01801895,
-0.031076353,
-0.007815769,
0.020979872,
-0.0013895998,
0.005021565,
0.0026808355,
0.0061052362,
-0.013037397,
-0.015124714,
-0.01609835,
-0.033237025,
0.006065224,
0.0069421637,
0.019739486,
0.031636525,
0.04940206,
0.011423561,
0.01737875,
0.02566133,
0.0033943912,
-0.0069488324,
-0.006742101,
0.006505361,
-0.032383427,
-0.0028808978,
0.021379996,
0.013110753,
0.024861082,
-0.012937365,
0.0091961995,
0.012423872,
-0.0072422572,
-0.01376429,
0.017045312,
-0.0333704,
-0.0101631675,
0.018552449,
-0.010003118,
-0.0054450305,
-0.02784868,
-0.021339985,
0.029635902,
0.003941228,
-0.006675414,
-0.003009271,
0.02316722,
-0.005341665,
0.029822629,
0.0016688535,
0.0020689783,
-0.0054516993,
-0.0037378317,
-0.0051582744,
-0.013150766,
0.00903615,
-0.015178064,
-0.006515364,
0.0074956696,
0.014151077,
-0.0034744162,
-0.013410847,
-0.0088761,
-0.022006858,
-0.0064320047,
-0.006955501,
-0.016671862,
-0.030542852,
-0.03609125,
-0.04468059,
-0.0033243694,
0.0030259432,
0.0039278907,
0.009549643,
-0.011843692,
-0.027768655,
0.021953508,
-0.0038011847,
0.009829731,
-0.024140857,
0.021900158,
0.037931822,
-0.00977638,
-0.013510877,
-0.027768655,
-0.011550266,
0.005728452,
0.0356111,
0.02120661,
-0.022113558,
-0.025581306,
-0.013397509,
-0.0018022284,
0.000012425748,
-0.030542852,
0.013804303,
0.0095163,
0.026808355,
-0.002757526,
0.0064886888,
0.0022423656,
0.032543477,
-0.009296231,
0.025141168,
-0.0029192432,
0.012430541,
-0.028435528,
-0.0041446253,
0.0072355885,
0.0334771,
0.010456592,
-0.010349892,
0.0081158625,
0.002272375,
-0.0030392807,
0.0025207857,
-0.0048215026,
0.025354568,
0.013104084,
-0.0010178172,
0.00016890682,
0.0034510756,
-0.013384172,
-0.02444762,
-0.0028858995,
0.039985795,
-0.014204427,
-0.0038512002,
0.02672833,
-0.0019806172,
0.0073156133,
-0.033130325,
-0.0027491902,
-0.0072355885,
-0.039665695,
-0.0114435665,
0.02768863,
0.012150453,
0.014871301,
-0.02683503,
-0.02476772,
0.0030626212,
-0.026541606,
-0.00092445477,
0.019205986,
-0.058684956,
-0.030276103,
0.0035644441,
0.02699508,
-0.003114304,
0.005611749,
0.009869743,
-0.007635713,
0.035050925,
-0.013650921,
0.029902654,
-0.009129512,
-0.01238386,
-0.030516177,
-0.001915597,
-0.0070688697,
-0.024154196,
0.008329263,
-0.00903615,
-0.014978002,
0.020886509,
-0.010990092,
0.030036028,
0.007055532,
-0.006141914,
0.028302154,
0.019566098,
0.010216517,
0.013317484,
-0.011523591,
0.018499099,
-0.029875979,
0.012017079,
0.015791588,
-0.0025457935,
-0.02093986,
0.023020508,
-0.031476475,
-0.013544221,
-0.009249549,
-0.023714058,
-0.032383427,
-0.0076490506,
0.007168901,
-0.00504824,
0.014871301,
-0.012590591,
-0.009549643,
0.012844003,
0.018445749,
0.0058051427,
-0.0064653484,
-0.025287881,
0.0050415713,
0.0052583055,
-0.019045936,
-0.007949145,
-0.004348022,
-0.024034157,
-0.013037397,
0.016631851,
-0.015791588,
0.028622255,
-0.0058318176,
0.0009744704,
0.012844003,
-0.0020239642,
-0.037905145,
-0.034464076,
0.0032360086,
0.00422465,
0.0060452176,
-0.00097113603,
-0.012770647,
0.0005830984,
-0.0017938925,
0.025274543,
0.014764601,
-0.015684888,
0.041826367,
-0.004474728,
0.0013145764,
-0.0022090217,
-0.025301218,
-0.0006777112,
0.023073858,
-0.00034698314,
-0.004718137,
0.029129079,
0.008042507,
0.004538081,
-0.009476286,
-0.0039045503,
-0.0022573702,
0.022540359,
0.021633409,
-0.036171272,
-0.028328829,
0.005395015,
0.0013429185,
-0.01371094,
0.0045847623,
0.013004053,
0.018925898,
-0.009756374,
-0.013937677,
-0.0335838,
0.009249549,
-0.019539423,
0.02035301,
0.025594644,
0.016445125,
0.013237459,
0.03675812,
-0.009202869,
-0.006445342,
-0.016565163,
-0.036918174,
-0.025287881,
-0.011403554,
-0.0010594969,
0.017192025,
-0.009783049,
0.017685512,
-0.018392399,
0.0031659866,
-0.00043263484,
-0.0079158,
-0.029262453,
0.024060832,
0.009796387,
-0.022406984,
-0.011750329,
0.007902463,
-0.008889438,
-0.018512437,
-0.0012837334,
0.0031576508,
-0.018098975,
0.004511406,
-0.003901216,
-0.0032510133,
-0.0040245876,
-0.017285388,
0.00059476873,
-0.02875563,
0.0048748525,
0.18138987,
-0.002800873,
0.011603616,
0.025181182,
-0.019726148,
0.017712187,
0.007448988,
-0.024781058,
-0.008622687,
-0.023233907,
0.0051682773,
0.04134622,
0.00016213386,
-0.003481085,
0.014791276,
-0.0043646935,
-0.026194831,
-0.014177752,
-0.028302154,
-0.006281958,
-0.01949941,
-0.0034977568,
0.011350204,
0.010543286,
0.04187972,
-0.012443879,
-0.026915055,
-0.0075490195,
-0.011977066,
-0.002560798,
-0.02099321,
-0.017232038,
0.011336867,
-0.011376879,
0.0321967,
0.014124402,
-0.0007873287,
-0.015098039,
0.017125338,
-0.0076223756,
0.00478149,
-0.011410222,
-0.021006547,
0.0036177943,
0.010269867,
-0.010056468,
-0.009176193,
-0.021966847,
-0.016525151,
0.009602993,
-0.06348646,
0.003346043,
0.011023436,
0.007168901,
-0.006955501,
-0.012403866,
0.01695195,
0.017938925,
0.012683953,
0.03990577,
-0.016538488,
0.0075490195,
-0.026875043,
0.04702799,
-0.030516177,
0.031023001,
-0.008762731,
-0.009636337,
0.06519365,
-0.038812097,
-0.016191714,
-0.005558399,
-0.0044780625,
0.014444502,
-0.0021940172,
-0.012690622,
0.033237025,
0.025487944,
0.021940172,
0.028382178,
-0.010183174,
-0.0033910568,
-0.037691746,
-0.007168901,
0.016965287,
-0.035424374,
-0.0012837334,
0.0016363433,
-0.010329886,
-0.011563604,
0.010376567,
-0.029449178,
0.007302276,
-0.007082207,
0.018739173,
0.0094229365,
0.0005422523,
-0.032543477,
-0.0069955136,
-0.025061144,
-0.031396452,
0.08029169,
0.017725524,
0.010063136,
-0.024874419,
0.0052082897,
-0.0075223446,
0.0015779918,
0.00340106,
-0.0347575,
0.011510254,
-0.01684525,
0.0007014686,
-0.019992897,
-0.019245999,
0.0064586797,
0.011490248,
-0.01812565,
0.024407607,
0.003302696,
0.01365759,
-0.02316722,
0.010483268,
0.009836399,
-0.0055950773,
0.007375632,
-0.022113558,
0.0018672487,
0.010843379,
-0.024087507,
-0.0037778441,
-0.0024657685,
0.0032676852,
-0.0060352143,
-0.016405113,
0.010556623,
0.0035577754,
-0.02471437,
-0.003150982,
-0.0062152706,
0.009022812,
0.018459087,
0.018432412,
0.02720848,
-0.008415956,
-0.015498163,
0.021353321,
0.029289128,
-0.026474917,
-0.037798446,
-0.00091611885,
-0.014804614,
0.010776692,
-0.0072555947,
0.0015613199,
-0.02864893,
-0.029929329,
-0.004254659,
0.00045472506,
0.0058851675,
-0.043346845,
-0.0016813574,
0.031476475,
0.013844315,
-0.018405737,
-0.011923716,
-0.16730547,
0.016605176,
0.0179656,
0.0026341544,
0.014537864,
0.024087507,
0.0029842635,
-0.008295919,
0.006065224,
-0.0084493,
0.014444502,
0.009649674,
-0.05420356,
-0.017845562,
0.017512124,
0.008082519,
-0.025754694,
0.02008626,
0.01727205,
-0.009542975,
0.025741355,
-0.02222026,
0.014151077,
-0.012630603,
0.0017205363,
0.03174323,
0.009009475,
-0.015018014,
0.0046047685,
-0.014897976,
0.0130907465,
0.0035311005,
0.041773017,
-0.023940794,
0.04649449,
0.0031626523,
-0.015844937,
-0.003624463,
-0.0016821909,
0.016178375,
0.008962793,
0.030596202,
0.018605798,
-0.01833905,
0.009743037,
0.029235778,
-0.017952261,
-0.018098975,
0.021980183,
-0.018445749,
0.0380652,
0.0056250864,
0.019846186,
0.022980496,
0.021740109,
0.02444762,
0.0043913685,
0.041719668,
0.0036444692,
0.005051574,
-0.004778156,
0.0033160334,
0.04070602,
-0.020126272,
0.019512748,
-0.014991339,
-0.00696217,
-0.006775445,
-0.037825122,
0.021033222,
-0.028382178,
0.0019672797,
0.0032260055,
0.0015446481,
0.019326024,
0.00022548695,
-0.007108882,
0.011123467,
-0.012050423,
-0.006265286,
-0.034570776,
0.041853044,
-0.034197323,
-0.035531074,
-0.014964664,
0.0026508262,
-0.004904862,
0.011763667,
-0.01116348,
0.017992275,
0.005585074,
-0.035851173,
0.018445749,
-0.0014454505,
0.006165255,
0.025034469,
0.011890372,
-0.016004989,
0.0029859305,
-0.02029966,
0.012290497,
-0.005431693,
-0.0061185737,
0.014644564,
0.027822005,
0.025074482,
-0.006181927,
0.017045312,
0.017872237,
0.004688128,
-0.00074773305,
-0.026088132,
0.02854223,
0.027088443,
-0.008455968,
0.026541606,
-0.0009286227,
-0.001602166,
0.0011253507,
-0.0033493773,
0.05516386,
-0.0033076976,
-0.0027808668,
0.004124619,
0.008676037,
-0.02470103,
-0.1285734,
-0.008889438,
-0.00818255,
0.0027441885,
-0.0042179814,
-0.0016813574,
0.0020906515,
0.033210352,
-0.024567656,
0.023513995,
-0.010036461,
0.0056951083,
-0.00083484355,
-0.0013379169,
0.010783361,
-0.011550266,
0.02152671,
-0.009689687,
-0.05468371,
0.017405424,
0.0060485518,
0.016231725,
0.0007114717,
0.016671862,
0.0006893815,
-0.002174011,
-0.00918953,
0.0344374,
0.012497229,
0.016045,
0.0021523375,
-0.010896729,
0.04193307,
-0.021299971,
-0.008169212,
-0.020046247,
-0.009329574,
-0.034730826,
0.040039144,
-0.018005611,
0.0066554076,
0.00510159,
0.0036444692,
0.016178375,
-0.005868496,
-0.018192336,
0.017712187,
0.006548708,
-0.010496605,
0.0025557966,
-0.03662475,
-0.006201933,
-0.051456038,
-0.023607358,
0.0051416024,
-0.02279377,
0.012103773,
0.017645499,
-0.0046014343,
-0.003964569,
-0.004154628,
-0.0056250864,
0.013237459,
0.0068488014,
0.034997575,
-0.030596202,
0.005004893,
-0.0063886577,
0.031423125,
-0.053696737,
-0.01333749,
0.009229544,
-0.017618824,
-0.0016713543,
-0.027875355,
-0.009909756,
-0.0034510756,
0.021179935,
0.003150982,
0.006065224,
-0.018312374,
-0.024380932,
0.01737875,
-0.015164726,
0.020366348,
-0.0013996029,
0.011756998,
-0.014751264,
0.027061768,
-0.010743348,
-0.014684577,
0.04139957,
0.008442631,
-0.0015913293,
-0.00016119608,
0.018632473,
-0.0052316305,
0.009449611,
0.015204739,
0.00972303,
-0.0341173,
-0.012390529,
-0.060285456,
0.009756374,
0.00531499,
-0.007662388,
0.017952261,
-0.020166285,
0.007202245,
0.0063419766,
-0.0045614215,
0.019899536,
0.0032059993,
-0.0026024778,
0.006115239,
-0.0040712687,
-0.015764913,
-0.0135175465,
0.0327302,
-0.04251992,
0.003032612,
0.013530884,
0.011363542,
0.0033243694,
0.0163651,
0.04564089,
-0.024327582,
-0.02151337,
-0.00640533,
0.029342478,
-0.009689687,
0.009302899,
0.005941852,
-0.04665454,
0.015564851,
-0.010549955,
-0.009843068,
0.0059085083,
-0.028835654,
0.0068754763,
0.020553073,
0.037558373,
-0.0037711754,
-0.04310677,
-0.0089694625,
-0.015778251,
0.0012962373,
0.015298101,
-0.01291069,
-0.0034777506,
-0.008809412,
-0.0073823007,
0.022153571,
0.018819198,
-0.008295919,
-0.037691746,
-0.013210784,
-0.010803367,
0.018179,
-0.034090623,
-0.00030676226,
0.0020256313,
0.003212668,
0.026848368,
0.018765848,
0.013951015,
-0.003276021,
0.010063136,
-0.028515553,
0.007735744,
-0.008322594,
-0.04091942,
-0.010529948,
0.018912561,
0.007989157,
0.009162855,
-0.0095963245,
0.0034344038,
-0.022180246,
-0.0020739797,
-0.010950079,
0.01057663,
0.012037084,
-0.0020122938,
-0.008495981,
0.0002298633,
0.024354257,
0.0026391558,
0.013670928,
0.036731448,
0.006355314,
-0.012123778,
-0.019312685,
0.013057403,
-0.004634778,
0.010189842,
-0.023260582,
0.009756374,
-0.024060832,
0.006812123,
0.011683641,
0.017525462,
-0.0056217522,
0.0020072924,
0.0021506704,
-0.049908888,
0.009042818,
0.048495114,
-0.026554942,
-0.018179,
-0.012463884,
-0.014791276,
0.007815769,
-0.002719181,
-0.012143785,
0.005705111,
-0.008636025,
-0.000532666,
0.011236835,
-0.0334771,
0.004061266,
0.0053316616,
0.010009786,
0.030142728,
0.013164103,
0.012550578,
0.00961633,
0.016805237,
0.011736992,
-0.0040946095,
0.013104084,
-0.0062519484,
-0.0017955597,
-0.016405113,
-0.03481085,
-0.01131686,
0.00067604403,
-0.011330198,
0.0031209728,
-0.0031009666,
-0.009829731,
0.08610684,
0.004614772,
-0.0033677162,
0.004851512,
-0.018085636,
-0.00334771,
0.019566098,
0.0051582744,
-0.0014421161,
-0.02258037,
0.007635713,
-0.010563293,
0.010970086,
-0.020166285,
-0.0067787794,
0.01791225,
-0.01960611,
-0.0051582744,
0.0048114997,
-0.01812565,
0.0053816773,
-0.026354881,
-0.007428982,
0.01641845,
0.0020072924,
0.017978936,
0.0153647885,
0.013524215,
0.0039679036,
-0.031263076,
0.018912561,
-0.008576007,
-0.050122287,
-0.010916736,
0.004921534,
-0.003095965,
-0.019992897,
0.0021890155,
0.0067987856,
0.014951327,
-0.009482956,
0.01073001,
0.0013379169,
0.0059751957,
0.0039979126,
-0.004017919,
-0.014137739,
-0.010136493,
-0.027128454
] |
People with Down syndrome (DS) exhibit abnormal brain structure. Alterations affecting neurotransmission and signalling pathways that govern brain function are also evident. A large number of genes are simultaneously expressed at abnormal levels in DS; therefore, it is a challenge to determine which gene(s) contribute to specific abnormalities, and then identify the key molecular pathways involved. We generated RCAN1-TG mice to study the consequences of RCAN1 over-expression and investigate the contribution of RCAN1 to the brain phenotype of DS. RCAN1-TG mice exhibit structural brain abnormalities in those areas affected in DS. The volume and number of neurons within the hippocampus | [
-0.024097484,
0.013038693,
0.031470012,
-0.036237407,
-0.02500928,
0.0044515217,
-0.0072227325,
0.017545573,
-0.029594315,
-0.0005719082,
-0.0044580344,
0.0114691,
-0.008329914,
0.015669877,
-0.005467524,
0.013533668,
0.021752864,
-0.027093388,
-0.006281628,
-0.005197241,
-0.024813896,
0.016516546,
0.0056531397,
-0.017480446,
0.005711755,
0.021922197,
0.030506112,
-0.0322255,
-0.0014149131,
0.0043408037,
0.024488254,
0.01809265,
-0.006099269,
-0.027666517,
0.008531812,
-0.0095543265,
0.012927975,
-0.00273539,
0.002961711,
-0.008421094,
0.010120943,
0.009684583,
-0.010882945,
0.0018789525,
0.0069817575,
0.015305159,
-0.011599356,
-0.014341259,
0.0028803006,
-0.001437708,
0.020958299,
0.02756231,
-0.029959034,
-0.0068710395,
-0.025986206,
-0.016620751,
0.015253056,
0.0063500125,
0.009638994,
-0.02098435,
0.032538116,
0.003852341,
-0.038608078,
0.022521378,
-0.0011511433,
-0.0022404147,
0.019799015,
0.015135825,
0.0018887217,
0.018170806,
0.033554118,
-0.0003423308,
-0.01593039,
0.012960539,
0.015161877,
-0.010120943,
-0.0165947,
-0.011592844,
0.006017858,
-0.0014523619,
0.028422005,
-0.027744671,
-0.0052135233,
-0.0030414932,
0.015200954,
0.02245625,
-0.009534788,
0.013520642,
-0.0128823845,
-0.0010046046,
-0.0102512,
0.012719564,
-0.0073464764,
0.0069817575,
0.008668581,
-0.007339963,
-0.007926119,
0.027614415,
-0.008355966,
-0.011371408,
-0.0155526465,
0.022130609,
-0.0044905986,
-0.023068456,
0.014614798,
-0.0119575625,
0.005633601,
0.012498127,
0.011996639,
-0.01836619,
-0.014341259,
0.024162613,
-0.007040373,
-0.022039428,
0.016920341,
0.005281908,
-0.006431423,
0.011189048,
0.014276131,
-0.0112541765,
0.033137295,
-0.003461571,
0.013520642,
-0.0075418614,
0.010062328,
0.019707834,
-0.03139186,
0.02020281,
-0.029307751,
-0.014575722,
0.0029551983,
-0.011156484,
0.023954201,
0.025543334,
-0.01425008,
0.006102525,
-0.0050800103,
0.00022957739,
-0.01542239,
-0.034465916,
0.001375022,
0.019929271,
-0.027093388,
-0.003917469,
0.004881369,
0.028969083,
0.022443224,
0.01220505,
0.025647538,
-0.010472637,
0.0077698105,
-0.008903043,
0.0074376557,
-0.005828986,
0.016737983,
0.031730525,
0.004568753,
0.028812775,
-0.0038686232,
-0.010811304,
0.02438405,
0.013898387,
-0.026832875,
0.013716027,
0.02257348,
0.02672867,
0.011736126,
-0.007828426,
-0.0073790406,
-0.021648658,
-0.0044091884,
0.018418293,
-0.008570889,
0.0370971,
-0.0018561576,
0.0010037904,
-0.0058648065,
0.00004439412,
-0.013885361,
-0.0038230333,
-0.001945709,
0.020059528,
0.006760321,
0.0050409334,
-0.0035169302,
0.010928535,
0.02672867,
-0.0026132744,
-0.015943417,
-0.018196857,
-0.0012276691,
-0.0039337515,
-0.0028477365,
-0.026963132,
-0.62981707,
-0.02275584,
0.0025595436,
-0.021609582,
0.011475612,
0.049653843,
-0.0038555975,
-0.00046159708,
-0.014510593,
0.024944153,
-0.016060647,
0.0025969923,
0.012752128,
-0.016529571,
-0.013468539,
-0.03436171,
0.007339963,
-0.005812704,
0.033345707,
0.013807207,
-0.02627277,
0.006923142,
-0.01854855,
0.0015231889,
0.0009134249,
0.021153683,
0.015878288,
-0.0031929167,
-0.009398019,
0.03087083,
-0.04769999,
0.0063109356,
-0.006503064,
0.009638994,
0.041109007,
0.009352429,
-0.0056759343,
0.03595084,
0.0057540885,
0.041682135,
-0.008108478,
0.00859694,
0.018978396,
0.0027923775,
-0.046189014,
0.037644178,
-0.00035963053,
0.011710075,
-0.0023543893,
-0.019277988,
-0.008395042,
0.0013237334,
-0.02179194,
-0.012628384,
0.026168564,
-0.028526211,
0.017519522,
-0.0139244385,
0.028005185,
0.008277811,
-0.00010405269,
0.014380337,
-0.0059169093,
-0.009775763,
0.0044808295,
-0.007639554,
-0.025777794,
0.0030463778,
0.008759761,
0.004705522,
0.021648658,
0.035976894,
0.0016469328,
0.010824329,
0.017871216,
0.03457012,
0.007659092,
0.00070908474,
-0.012563256,
0.010681047,
-0.0053112158,
-0.0031375575,
-0.039077003,
-0.0025660563,
0.013390386,
0.0047152913,
-0.0023560175,
0.016620751,
-0.0044580344,
-0.014224028,
0.003142442,
0.0018398755,
-0.0012358101,
-0.029333802,
-0.013598796,
0.009130993,
-0.019929271,
0.020606605,
0.0028868134,
0.007001296,
-0.040848494,
-0.006086243,
-0.0035657764,
-0.021140657,
0.027848877,
0.010492175,
-0.02206548,
0.017636754,
0.050669845,
-0.033449914,
-0.018340139,
0.005386113,
-0.0048846253,
-0.0077698105,
-0.0094566345,
-0.02236507,
0.0059201657,
-0.013703002,
0.00040684856,
-0.044834346,
0.0043408037,
0.0062620896,
-0.006460731,
-0.027848877,
0.017141778,
-0.0019489655,
-0.0032075704,
-0.013703002,
0.0065258592,
0.00221762,
0.008916069,
-0.027275747,
0.012048742,
-0.02889093,
0.010322841,
-0.007463707,
0.0062913974,
0.026129488,
-0.011911972,
-0.03436171,
-0.0012089447,
-0.0048260097,
0.015331211,
-0.006773347,
-0.0030382369,
0.012302742,
-0.014992543,
-0.021153683,
-0.0069426806,
0.004620855,
-0.00016811251,
-0.011703562,
0.00019355328,
0.03441381,
0.023941176,
-0.0067538084,
0.011045766,
-0.015591724,
0.015305159,
-0.020059528,
0.0034290068,
0.021804966,
-0.0060667046,
-0.013071257,
-0.037149202,
-0.030792678,
0.008792325,
0.01893932,
-0.034049094,
-0.01764978,
-0.018769987,
-0.0005531838,
0.013188488,
0.013351309,
0.0105052,
0.026780771,
0.015591724,
-0.020841068,
-0.0036602125,
-0.0054349597,
-0.0034029556,
-0.012993103,
-0.009684583,
-0.015774082,
0.029985085,
0.03381463,
0.02969852,
0.004969292,
-0.007984734,
0.04525117,
-0.015331211,
0.04842943,
-0.030323753,
0.00399888,
0.008974684,
-0.006213243,
0.031209499,
0.007040373,
-0.000070572656,
0.034882735,
0.006288141,
-0.02420169,
-0.008811864,
-0.014054695,
0.032564167,
-0.048715994,
0.0028330826,
-0.012283204,
-0.010694073,
0.0074050915,
-0.0102512,
0.032095242,
0.0070859627,
-0.0041291364,
-0.011631921,
0.0063434998,
-0.0013278039,
-0.0102512,
0.0038002385,
-0.020828042,
0.004913933,
-0.007359502,
0.00942407,
0.0026735181,
0.00443524,
0.025543334,
0.0070533985,
0.028291749,
-0.009293813,
-0.01815778,
-0.0072422707,
0.022443224,
0.007307399,
0.025347948,
0.00195385,
0.013351309,
-0.009463147,
-0.010466124,
0.026012257,
0.023576457,
0.004829266,
0.014679926,
0.0038100076,
0.0035657764,
0.009521763,
-0.0045361887,
0.017089676,
0.032668374,
-0.017727932,
0.006366295,
-0.005884345,
0.0049888305,
-0.024488254,
-0.0005531838,
-0.005272139,
0.009306839,
0.0049758046,
0.025829898,
0.040874545,
0.02011163,
0.012087819,
-0.003679751,
0.007991247,
-0.013403411,
-0.013103821,
0.008922582,
0.02128394,
-0.006193705,
0.008505761,
-0.0031310448,
-0.022873072,
0.018288037,
-0.01034238,
-0.041082952,
0.0052460874,
-0.00018999157,
-0.007847965,
0.014471516,
0.03652397,
0.03946777,
0.0023429918,
-0.020437272,
0.010798278,
0.034804583,
-0.0018822089,
-0.022521378,
-0.0010599636,
0.016321162,
-0.008876992,
0.014315208,
0.01425008,
0.024097484,
0.0037872128,
0.0137551045,
-0.009365454,
-0.0042333417,
0.013885361,
-0.004197521,
0.0037155715,
-0.0124199735,
0.012628384,
0.0077177077,
-0.009508737,
-0.008525299,
0.030245598,
0.019121679,
-0.02128394,
0.0014556183,
-0.0018496447,
-0.020150706,
0.00045752656,
-0.023876049,
-0.013624848,
-0.0043570856,
0.006304423,
-0.000021090387,
-0.0056498833,
-0.0037188279,
0.026207643,
0.008225709,
-0.02167471,
-0.036393713,
-0.002569313,
0.00007230263,
0.030245598,
0.036445815,
-0.03519535,
0.0027940057,
0.00070908474,
0.004135649,
-0.009039813,
-0.013520642,
0.018001473,
-0.010270738,
-0.021922197,
0.0032743271,
0.019903218,
0.005187472,
-0.0025465179,
0.03128765,
0.00503442,
-0.013507617,
0.011807767,
0.002015722,
-0.0046892404,
0.012446024,
0.015969468,
0.0361853,
0.043974653,
-0.013572745,
-0.0012333678,
0.02792703,
0.0076851435,
-0.025035333,
-0.010974124,
0.0113518685,
0.0020661964,
0.024240766,
-0.012094332,
-0.009808327,
0.017050598,
0.018717883,
-0.018756961,
0.004269162,
0.028838826,
0.014771107,
0.02889093,
-0.009873455,
-0.0069817575,
-0.0025872232,
-0.0014124708,
-0.010518226,
-0.00668868,
-0.018327113,
0.027458107,
-0.0370971,
-0.010479149,
-0.004891138,
0.0011047394,
-0.01234182,
0.012784692,
-0.008948633,
0.010700585,
-0.005031164,
-0.016373264,
-0.008271298,
0.001421426,
-0.00024504538,
-0.003917469,
-0.015135825,
-0.007151091,
-0.0010428674,
-0.03535166,
-0.04118716,
0.01094156,
-0.019929271,
-0.03787864,
0.026012257,
0.012608846,
0.013351309,
0.017115727,
-0.010238174,
-0.008733709,
0.02675472,
-0.014692953,
-0.032720476,
0.000074795826,
-0.00421706,
0.016229982,
0.016060647,
0.0040672645,
-0.017480446,
-0.025126511,
0.008844428,
0.0066300645,
-0.021922197,
0.014927414,
0.0155526465,
0.01176869,
0.028656468,
0.02332897,
0.042646036,
0.0015288877,
-0.0074181175,
-0.008395042,
-0.01211387,
-0.033345707,
-0.013351309,
-0.022169685,
-0.03298099,
0.008577402,
-0.009586891,
-0.012862846,
-0.021257889,
0.030349804,
-0.030219547,
0.00451665,
0.012328794,
0.01650352,
0.01764978,
0.010446585,
0.02714549,
-0.0050930358,
-0.011247664,
0.003679751,
-0.031001087,
0.023498304,
-0.0008938864,
-0.026911028,
0.012165973,
0.015253056,
-0.019538501,
-0.032433912,
-0.021140657,
0.013937464,
0.040145107,
-0.003477853,
-0.024006305,
-0.006346756,
0.007359502,
-0.003937008,
0.011840331,
0.0010444957,
-0.0047413427,
-0.013455514,
0.019564552,
-0.017311111,
-0.023563432,
0.032928888,
-0.036055047,
-0.008245247,
0.019603629,
0.023563432,
0.003852341,
-0.0052558566,
0.010785253,
-0.024735741,
-0.03008929,
0.0034420325,
-0.05189426,
0.023172662,
-0.01255023,
0.03928541,
0.029021187,
0.026416052,
0.005076754,
0.02302938,
0.029359853,
0.0025644281,
0.0014596888,
0.011390946,
0.0063500125,
-0.02558241,
0.010257713,
0.0038328026,
0.00088411715,
0.03628951,
-0.0244101,
0.02257348,
0.012100845,
0.010329354,
-0.02272979,
0.017206905,
-0.049731996,
-0.01923891,
0.014719004,
0.0041193673,
0.003578802,
-0.030688472,
0.0060308836,
0.035091147,
-0.00859694,
-0.008271298,
-0.006193705,
0.019264963,
-0.022690712,
0.017884241,
0.0030186984,
0.02606436,
0.00047869325,
-0.005203754,
-0.00037163857,
-0.010023251,
0.022299942,
0.00057842105,
0.023107534,
0.0051060617,
-0.0032613014,
-0.006359782,
0.0016819392,
-0.018170806,
0.006851501,
-0.025777794,
-0.026207643,
-0.037461817,
-0.041499775,
-0.018261986,
-0.038920693,
0.025595436,
0.020320041,
-0.007672118,
0.028578313,
-0.023276867,
-0.019655732,
-0.0051288563,
-0.005995063,
0.030037189,
-0.019968348,
-0.0025839666,
0.015774082,
-0.01524003,
-0.015018594,
-0.016790085,
0.025243742,
-0.009437095,
0.040666133,
0.018665781,
-0.024032356,
-0.008088939,
-0.008258273,
0.0051060617,
-0.011853357,
-0.027614415,
0.007750272,
-0.010414021,
0.0031831474,
0.0046273684,
-0.0021883121,
-0.0046762144,
0.007900067,
-0.034205403,
-0.030297702,
-0.012537205,
-0.009899507,
-0.009541301,
0.0234462,
-0.0064574745,
0.033475965,
0.002914493,
0.0056368574,
-0.003468084,
0.0033231734,
-0.021205787,
0.005969012,
0.005828986,
0.030636368,
-0.005164677,
0.0054838057,
-0.0025969923,
0.008277811,
0.012608846,
-0.008101965,
-0.023276867,
0.049054664,
-0.009248224,
-0.020541476,
0.015135825,
0.0066137826,
0.0012814,
0.015461467,
-0.009704122,
-0.027171541,
-0.0420208,
-0.019095628,
0.02059358,
-0.0052981903,
-0.008342939,
0.0035690328,
-0.0053958828,
-0.010557303,
-0.031912886,
-0.029646419,
0.013989567,
-0.03649792,
0.007268322,
0.017571624,
0.017102702,
0.025569385,
0.016177878,
0.0020564273,
0.010544278,
0.046605837,
-0.007750272,
0.014197977,
-0.0042398544,
0.0023267097,
-0.022195736,
0.0085578635,
-0.013468539,
-0.017506497,
0.0036536995,
-0.03868623,
-0.04045772,
-0.021909172,
-0.0006545398,
-0.012628384,
0.011293253,
-0.011664485,
0.033059143,
-0.008636017,
0.007444169,
-0.0008662069,
-0.04509486,
0.01887419,
-0.027692568,
-0.019551527,
0.00050759397,
0.0038458281,
-0.025621487,
-0.017780036,
-0.004259393,
0.010153508,
-0.019264963,
-0.0025106973,
-0.00018500518,
0.01094156,
-0.011736126,
0.0185225,
-0.011911972,
-0.01376813,
-0.033554118,
0.024045382,
0.017558599,
-0.01034238,
-0.0066007567,
0.002093876,
-0.010915509,
-0.00093866215,
-0.008401555,
-0.024266819,
0.016399315,
-0.027223645,
-0.048533637,
-0.0029405444,
-0.027015233,
0.028526211,
0.031808678,
0.00024789473,
-0.008935608,
0.010908996,
-0.048715994,
-0.006219756,
-0.0002656015,
0.012823769,
0.015057671,
0.02438405,
0.0023950946,
-0.019147731,
0.0067082187,
0.0024097485,
-0.011443049,
0.006727757,
-0.006131833,
0.018470395,
0.0069036037,
0.0057606013,
-0.0051939846,
-0.005806191,
0.032486014,
-0.002391838,
-0.0119836135,
0.015591724,
-0.029229596,
0.029854828,
-0.030636368,
0.005187472,
-0.029047238,
-0.00063093076,
0.013611822,
-0.01719388,
0.013416437,
-0.017519522,
-0.01264141,
0.0057931654,
0.004868343,
-0.007164117,
0.010765714,
-0.0055131135,
-0.011710075,
-0.0027988902,
0.010407508,
0.011052279,
-0.0070664245,
0.004630625,
-0.013012641,
-0.009450122,
0.008590427,
0.0048650866,
-0.0117231,
-0.021127632,
-0.0010347264,
0.014836235,
-0.032095242,
-0.014575722,
-0.018913269,
-0.008036837,
0.0045654965,
-0.034491967,
0.003917469,
-0.022143634,
-0.006450962,
-0.025895026,
0.019955322,
-0.0012048743,
-0.04277629,
-0.020554503,
-0.005405652,
-0.028213594,
0.013155924,
0.0018529012,
0.015852237,
-0.037435766,
0.011586331,
0.0012569769,
-0.020880144,
0.006851501,
-0.007502784,
-0.012980077,
-0.022260865,
-0.00092889287,
0.19184202,
-0.003539725,
-0.009638994,
0.01151469,
-0.0042561367,
0.0021476068,
0.025413077,
0.007118527,
-0.010856894,
-0.00092400826,
0.006805911,
0.010557303,
-0.011781716,
-0.0016689136,
0.016946392,
-0.0044808295,
-0.017571624,
-0.021544453,
-0.0067538084,
-0.010042789,
0.014810183,
-0.02052845,
0.00084504014,
-0.0018984909,
0.020658707,
-0.012270179,
-0.021414196,
-0.029932983,
0.027249696,
0.025699642,
-0.019916246,
0.0038002385,
0.003875136,
0.0051842155,
-0.0007155976,
0.005995063,
-0.010837355,
-0.018314088,
-0.007620015,
-0.019681783,
-0.0025921077,
0.012439512,
-0.0046273684,
0.019343115,
-0.019460347,
0.0065519107,
0.02020281,
-0.03962408,
0.018665781,
-0.020176759,
-0.05444729,
0.00018683691,
0.015227005,
0.026129488,
0.0006089499,
-0.0069426806,
0.012660949,
0.012836795,
0.00023853254,
0.022781892,
-0.013598796,
0.02257348,
-0.027301798,
0.05179005,
-0.008785812,
0.027093388,
-0.01974691,
0.017832138,
0.016229982,
-0.0065616798,
0.0008157324,
-0.03381463,
-0.021088555,
0.004259393,
-0.0011291625,
-0.0020661964,
0.04668399,
-0.012752128,
0.010707098,
0.019017475,
0.010173046,
-0.0024097485,
-0.026585387,
-0.0047608814,
-0.012700025,
-0.034205403,
0.046006657,
-0.0071445783,
-0.0022762353,
-0.014575722,
0.014132849,
0.0042919572,
-0.01689429,
-0.0065193465,
0.0026295565,
-0.00023507258,
0.022482302,
0.0042333417,
-0.015826186,
-0.0019912987,
-0.03438776,
0.069973886,
-0.00077462016,
0.020906195,
-0.008785812,
0.009319865,
0.01933009,
0.021544453,
0.011697049,
-0.012465564,
-0.0008776043,
-0.009886481,
-0.010075353,
-0.005304703,
0.0069817575,
0.02224784,
0.013403411,
-0.016034596,
0.02312056,
-0.00473483,
-0.010739663,
-0.016907316,
-0.017428342,
0.021544453,
-0.021023426,
-0.0077893487,
-0.004350573,
-0.0039891107,
-0.0043473165,
-0.04037957,
0.0015354005,
-0.02052845,
0.012107357,
-0.006522603,
0.004672958,
-0.017532548,
0.0132926935,
-0.0018463883,
-0.021622607,
0.02107553,
-0.0033345707,
0.005233062,
0.008303863,
0.005467524,
0.0016265801,
-0.027406003,
0.009280788,
0.0059592426,
-0.010049302,
-0.015748031,
-0.030245598,
-0.012374383,
-0.0031766347,
0.0021850558,
0.011566793,
-0.027249696,
-0.03571638,
-0.027171541,
-0.02459246,
0.011644946,
-0.03553402,
0.0027419028,
0.008668581,
-0.0010192584,
-0.0044743167,
-0.0009809956,
-0.16162248,
0.017063623,
0.020580554,
-0.027588364,
0.020046502,
0.009007249,
0.03008929,
-0.014237054,
0.0021003888,
0.031652372,
0.039728284,
-0.019134704,
-0.010837355,
0.000984252,
0.013898387,
-0.02383697,
-0.010602893,
0.016907316,
0.023381073,
-0.0105507905,
0.020398194,
-0.024423126,
0.005233062,
0.011938024,
0.0038490847,
0.01436731,
-0.010160021,
-0.009202634,
-0.007183655,
-0.025152564,
-0.0028379671,
-0.021804966,
0.037227355,
-0.013520642,
0.018743934,
-0.007307399,
-0.009684583,
-0.012074794,
-0.02771862,
0.0003382603,
0.01728506,
0.044625934,
0.007046886,
-0.0031212755,
-0.009821353,
0.013045206,
-0.0015964584,
-0.021648658,
0.003415981,
0.014523619,
0.026311848,
-0.011149971,
0.010400996,
0.009443609,
0.029438008,
0.013084282,
0.00008227541,
0.019590603,
-0.009717148,
-0.016256033,
-0.0032564169,
-0.02296425,
0.036992896,
0.0060113454,
0.021427222,
-0.0044254703,
-0.007782836,
-0.0027858645,
-0.043609932,
0.010120943,
-0.030688472,
-0.002250184,
0.0056205755,
-0.027510209,
0.0069491933,
0.026025282,
0.013807207,
-0.005220036,
-0.0013953745,
-0.006219756,
-0.004705522,
-0.0044026757,
-0.03454407,
-0.013846284,
-0.008114991,
-0.019564552,
0.014810183,
0.0042072902,
0.010440072,
-0.0057736267,
0.0021508632,
-0.021804966,
0.014953466,
-0.008362479,
0.01854855,
0.020215835,
0.010707098,
-0.009756224,
0.00573455,
-0.00451665,
0.01238741,
-0.015982494,
-0.01484926,
0.0022143633,
0.032121293,
-0.016829161,
-0.027353901,
0.015005568,
0.049627792,
0.00014582642,
0.010531252,
-0.012055255,
0.003696033,
0.039858542,
-0.0008808607,
0.019538501,
-0.010166533,
0.0064737564,
0.013286181,
-0.0039891107,
0.07799769,
0.015578697,
0.0012512781,
0.016920341,
0.025217691,
-0.003751392,
-0.13202816,
-0.046501633,
-0.010414021,
0.01298659,
-0.005767114,
0.009059352,
-0.0057833963,
0.029932983,
-0.023341995,
0.021661684,
0.0065128338,
-0.016229982,
0.009736686,
-0.008173606,
0.0048422916,
0.0063728075,
0.016633777,
0.00039707933,
0.013520642,
0.027822824,
0.010361918,
-0.01542239,
0.009319865,
-0.0052558566,
0.0016298366,
0.015109774,
-0.029021187,
-0.0005055587,
0.004008649,
0.005819217,
0.007659092,
-0.015682904,
0.017897267,
-0.0033296861,
-0.025868975,
-0.020033477,
0.024097484,
-0.03884254,
0.044052806,
-0.01215946,
0.009801814,
0.0076069897,
0.008499248,
0.019186808,
-0.017871216,
-0.0045231627,
-0.03300704,
0.015604749,
0.0072422707,
-0.030688472,
-0.017141778,
0.0019668757,
0.002461851,
-0.008284324,
0.013155924,
-0.017545573,
0.0032857244,
0.014562696,
-0.010681047,
-0.019121679,
0.013227565,
0.006320705,
-0.029828778,
0.024605485,
0.025426103,
-0.037566025,
-0.029776676,
-0.040145107,
0.022495328,
-0.040066954,
0.008154067,
0.011990126,
-0.00048072851,
-0.022352045,
-0.021414196,
0.024475228,
-0.005737806,
-0.0066202953,
0.011592844,
-0.016816135,
-0.019134704,
-0.0126869995,
0.043818343,
-0.021257889,
0.004829266,
0.013689976,
0.0053177285,
0.0012040602,
0.0042398544,
-0.011110894,
-0.004682727,
0.030193496,
-0.021114606,
0.0009679699,
-0.011338843,
0.011625408,
-0.0020450298,
0.0104530975,
0.008909556,
0.0017796317,
-0.027406003,
-0.03008929,
-0.04433937,
0.014523619,
-0.0049171895,
-0.0142891565,
0.0056466265,
-0.015070696,
-0.005405652,
-0.007352989,
-0.013097309,
0.0013074513,
-0.011807767,
-0.0037644177,
-0.0024471972,
0.010518226,
-0.026350925,
-0.005819217,
0.02459246,
-0.02206548,
0.022430198,
0.020150706,
0.0031929167,
0.0060211145,
0.00045427014,
0.027041284,
-0.02468364,
-0.002046658,
-0.0074571944,
0.015318184,
-0.0034029556,
-0.0019424526,
-0.0056694215,
-0.03376253,
-0.005584755,
0.009808327,
0.009925558,
-0.017493472,
0.008798838,
0.016829161,
-0.0036764946,
0.046006657,
-0.00356252,
-0.03868623,
-0.0024732486,
0.004923702,
0.0065356283,
-0.013416437,
-0.052988414,
-0.0011723101,
-0.0035332122,
-0.0074181175,
-0.00038893826,
0.019994399,
0.009886481,
-0.013058231,
-0.02185707,
0.009691096,
-0.002750044,
-0.002507441,
-0.013520642,
0.0029405444,
0.023407124,
0.0058322423,
0.026963132,
-0.0072618094,
-0.011631921,
-0.0011625407,
-0.035221405,
0.015891314,
0.0023853253,
-0.020828042,
-0.023849996,
-0.008766274,
0.029307751,
0.0011975473,
0.0050800103,
0.003484366,
-0.024865998,
-0.010192584,
-0.033554118,
0.009313352,
0.0031603526,
0.011911972,
-0.016685879,
0.016855214,
0.025921078,
0.011247664,
0.0021769146,
0.024566408,
-0.0076135024,
0.023185687,
-0.011911972,
0.024462203,
0.0042919572,
0.02459246,
0.02420169,
0.027796773,
0.0048715994,
-0.0025334922,
0.0029128648,
0.03162632,
-0.013911412,
-0.0022045942,
-0.00590714,
-0.027379952,
-0.0022778634,
0.02795308,
-0.02371974,
-0.0312616,
0.018301062,
0.014601773,
0.015370287,
0.0033410836,
0.0038946744,
-0.0037644177,
-0.009625968,
-0.007984734,
-0.010309815,
-0.013937464,
-0.008030323,
0.024761792,
-0.0015117915,
-0.01142351,
0.0139244385,
-0.010485662,
0.023276867,
-0.011013201,
0.023732765,
-0.03537771,
0.015174902,
-0.017988447,
0.007320425,
0.0025562872,
-0.030740574,
0.0004664817,
0.0036146226,
-0.01854855,
-0.010694073,
0.024644563,
-0.027275747,
0.0723185,
0.014028643,
-0.00898771,
-0.02013768,
-0.019017475,
0.009476173,
-0.007248784,
0.0052460874,
-0.012530692,
-0.0016111122,
0.020932248,
-0.03769628,
0.028422005,
-0.0153572615,
-0.015135825,
0.022534404,
0.00547078,
0.033059143,
-0.0018463883,
-0.010511713,
0.00091423903,
-0.0132210525,
0.022443224,
0.013305719,
-0.02020281,
0.0032873526,
0.0527279,
-0.012465564,
0.0006883251,
-0.0075223227,
0.015161877,
-0.016151827,
-0.04686635,
-0.008017298,
-0.012608846,
0.0011438164,
0.017701881,
0.0005474851,
-0.0041942648,
0.0009370339,
0.006955706,
0.004236598,
-0.008831402,
0.0014580606,
-0.005281908,
-0.009365454,
-0.014705978,
-0.030375855,
-0.019590603
] |
CONTEXT Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer, and vitamins E and C are among the most common individual supplements. A large-scale randomized trial suggested that vitamin E may reduce risk of prostate cancer; however, few trials have been powered to address this relationship. No previous trial in men at usual risk has examined vitamin C alone in the prevention of cancer. OBJECTIVE To evaluate whether long-term vitamin E or C supplementation decreases risk of prostate and total cancer events among men. DESIGN, SETTING, AND PARTICIPANTS The Physicians' Health Study II is a randomized, double-blind, placebo-controlled factorial trial of vitamins E | [
0.012842993,
-0.05289583,
0.015264372,
-0.036959928,
-0.034842025,
0.027920112,
-0.003561041,
-0.0036191542,
-0.0134693235,
-0.0029831387,
-0.0055627143,
0.013314355,
0.0017417785,
0.02563433,
-0.02373597,
0.0052237213,
0.050545476,
-0.023981337,
0.0012114965,
0.01721439,
-0.02887575,
0.0031655494,
0.005210807,
-0.007348078,
0.029883044,
-0.009401407,
0.011267483,
-0.040395055,
0.010440986,
-0.0032769328,
0.03032212,
0.004423052,
-0.0020533293,
-0.04403681,
-0.008432856,
0.03153604,
-0.0013777645,
-0.011738844,
0.01962931,
-0.030477088,
0.015419341,
0.007703213,
0.004852443,
-0.02045581,
-0.017408099,
0.0044262805,
-0.0077548693,
-0.001425385,
-0.027300239,
0.018454134,
0.0100664785,
0.0067217476,
0.011977754,
0.008762163,
-0.009259352,
-0.0057628816,
-0.012681568,
0.012145637,
-0.011861527,
-0.012520143,
-0.0002760372,
0.0073028784,
-0.009168955,
-0.007432019,
-0.014244164,
0.009039815,
0.007916295,
-0.0038838917,
0.009059185,
0.03153604,
0.022986956,
0.0382255,
-0.03006384,
0.011151257,
-0.00079663366,
0.010189163,
-0.04958984,
-0.009950253,
0.017782606,
-0.0069477432,
0.011977754,
-0.012177921,
-0.023968423,
0.012520143,
0.006999399,
0.000051908308,
0.0024488212,
0.015948815,
-0.025802214,
-0.021566413,
0.0047588167,
-0.0023487376,
-0.008439313,
0.008736335,
-0.014567015,
0.024226703,
0.018492877,
0.016013386,
-0.008045435,
-0.031742662,
-0.0064699245,
-0.030683713,
-0.009162498,
-0.0017902061,
-0.015819674,
0.017885918,
-0.023206495,
0.0138954865,
0.02630586,
-0.011351424,
-0.024936974,
0.037993047,
-0.013533893,
-0.03623674,
0.040369228,
-0.009033358,
0.0028023424,
0.001975845,
-0.021024026,
0.018893212,
0.0015343471,
-0.005824223,
0.046464644,
-0.0013721146,
0.04122155,
-0.016904453,
-0.023710141,
-0.012629912,
-0.004251941,
-0.004216428,
0.02479492,
-0.008955874,
0.020856144,
0.01490278,
-0.0403434,
0.024265444,
-0.0243171,
-0.020287925,
-0.015122318,
-0.035642695,
0.003042866,
0.0026748164,
0.010350588,
0.015974643,
-0.024084648,
0.0017821349,
0.024665779,
0.017653465,
-0.015974643,
-0.0012437816,
0.0043520248,
-0.016839882,
0.03471289,
0.001035543,
-0.008342457,
-0.017227303,
-0.022534966,
0.020016732,
-0.0147478115,
-0.036262568,
0.022367083,
-0.0326983,
0.00022357398,
-0.00047822233,
-0.006967114,
0.03321486,
0.028230049,
0.009304551,
-0.01727896,
0.0038645207,
-0.0005254392,
0.033576455,
-0.030683713,
0.011867985,
-0.021708468,
0.020907799,
-0.030270465,
0.017627638,
-0.0062988135,
-0.0010694424,
-0.017511413,
0.011654903,
0.026331687,
-0.0059856484,
-0.0056498838,
-0.0013745361,
0.024962801,
0.01302379,
-0.015664706,
-0.017046507,
-0.0009378807,
0.009543461,
-0.027739316,
-0.02649957,
-0.6289644,
-0.0138954865,
-0.0041454006,
0.012784881,
0.03636588,
0.017175646,
0.008090634,
0.007063969,
-0.02688699,
0.020920713,
-0.0036320682,
0.014605757,
-0.0070510553,
-0.011441822,
0.0020065159,
-0.03148438,
-0.0019710024,
-0.014554101,
0.012055238,
-0.008090634,
-0.032904923,
-0.0025666615,
0.0025392193,
0.007974408,
0.018260425,
0.038173843,
0.035926804,
-0.013495151,
0.015871331,
0.04150566,
0.00028935476,
0.0208174,
0.0112158265,
0.013701776,
0.040550023,
-0.0072964216,
0.018970696,
-0.01002128,
0.009698429,
0.01988759,
-0.0003513017,
0.0057628816,
0.021346876,
0.015367684,
-0.027894285,
-0.0012026181,
0.020584948,
-0.010118135,
-0.0018386337,
0.021127338,
0.02649957,
0.008826733,
-0.031303585,
-0.03677913,
0.010738008,
-0.0061955014,
0.03639171,
-0.04047254,
0.0029088832,
-0.0025424478,
-0.0025618188,
-0.0012623455,
-0.0015052905,
-0.012223121,
0.009646773,
0.047601078,
-0.018531619,
0.023890939,
-0.0060502184,
0.019655138,
0.018195854,
0.022909472,
-0.009750086,
-0.022392912,
0.04114407,
0.005530429,
0.0074643036,
-0.011293311,
-0.038716234,
0.0007764555,
0.006059904,
-0.00008328534,
-0.034609575,
-0.007942122,
0.026809506,
-0.0030186523,
-0.025363136,
0.0075224168,
0.0051623797,
-0.0019629311,
0.010208533,
-0.0010274717,
-0.006473153,
-0.030477088,
-0.015716363,
0.007942122,
0.0022906244,
-0.004177686,
-0.0128752785,
-0.028901577,
-0.039723527,
-0.014644499,
0.01034413,
-0.0005714454,
0.021566413,
-0.017679295,
-0.011189999,
-0.010182705,
0.023206495,
-0.02042998,
0.02023627,
-0.0072705937,
-0.005388375,
0.0012316747,
-0.00017494462,
-0.013611377,
0.0014964121,
0.013288527,
0.0021243563,
-0.019383945,
0.01956474,
0.012403917,
0.00423257,
0.014373304,
0.025957182,
0.009969624,
-0.0061599878,
0.0051817507,
-0.014980264,
-0.008058349,
0.015432254,
0.007722584,
0.0067863176,
-0.01358555,
0.00024375213,
0.0022728676,
0.006915458,
-0.009543461,
-0.0077290414,
-0.008478055,
-0.038432125,
-0.0069477432,
0.006773404,
0.008323086,
0.01760181,
-0.02142436,
-0.02807508,
-0.0007050248,
-0.026099235,
0.0056272843,
0.01840248,
-0.00945952,
-0.01721439,
0.008800905,
0.0038516065,
-0.0024536639,
0.0048104725,
-0.023180667,
-0.012487858,
-0.024472069,
0.021514758,
0.00883319,
-0.004326197,
-0.01904818,
-0.012991505,
-0.0030008955,
0.0010113292,
0.030787025,
0.0010581425,
-0.029469796,
-0.0073093357,
-0.0181442,
0.007406191,
0.034532093,
-0.019577656,
0.0026990303,
-0.009420778,
0.015199802,
-0.002339052,
-0.005194665,
-0.002442364,
-0.038148016,
-0.005553029,
0.0071091685,
0.043313626,
0.01503192,
0.013204586,
-0.0029411681,
-0.010821949,
0.011687188,
-0.014102111,
0.00019562723,
0.0043681674,
0.008026063,
-0.0004346375,
-0.012681568,
-0.0038548352,
0.011344967,
0.0064892955,
-0.009834027,
0.008348914,
-0.017563067,
0.029753903,
-0.043132827,
0.03716655,
-0.026125064,
-0.012533057,
0.015638879,
0.014567015,
-0.0010363501,
0.0006222944,
-0.0041066585,
-0.022470396,
0.023658486,
-0.009246439,
0.019668054,
0.000099680095,
-0.014399133,
-0.00978237,
-0.018906126,
-0.00016435109,
-0.018957783,
0.008297258,
-0.01786009,
-0.010744465,
0.040240087,
0.016594516,
0.005779024,
-0.025685987,
-0.018299166,
-0.010964003,
0.0054820017,
-0.007038141,
-0.0068250597,
0.013960056,
0.024368757,
0.016181268,
-0.034532093,
0.016801141,
0.011784044,
0.004494079,
0.012675111,
0.0028523842,
0.03256916,
0.008813819,
-0.025492277,
0.03572018,
0.009530547,
0.009556375,
0.035616867,
0.007722584,
0.026409172,
-0.026396258,
-0.01926772,
-0.028152565,
-0.006812146,
0.0023374376,
0.022341255,
0.040240087,
0.027765144,
0.054032262,
-0.011131885,
0.022212116,
0.020249184,
-0.016878625,
0.00021530094,
0.0045425068,
0.0071349964,
-0.011370795,
0.0098533975,
-0.029211514,
-0.02071409,
0.019719709,
-0.024756176,
0.0100664785,
0.012494314,
0.034170497,
0.020081302,
0.007528874,
-0.000693725,
-0.012081066,
-0.029728075,
0.015780933,
0.03760563,
-0.005201122,
-0.01833791,
-0.0104474425,
-0.0018709187,
0.0042939116,
0.0011364338,
0.010189163,
0.017343529,
-0.006192273,
0.008310172,
-0.009259352,
-0.010137506,
0.0036578963,
-0.008051892,
0.017743865,
-0.008516797,
-0.0020145872,
-0.016917367,
-0.013947142,
0.004261627,
0.027610175,
0.023916766,
-0.010221447,
-0.024007164,
-0.015199802,
-0.011261025,
0.00016879028,
-0.0186995,
0.0112158265,
-0.016271666,
0.012649283,
0.003912948,
0.0060566757,
-0.009478891,
0.00038056003,
-0.0015545252,
-0.008122919,
-0.04049837,
-0.0020549435,
0.016103784,
0.048711684,
-0.009808199,
0.0064085824,
0.0041260296,
0.016839882,
0.005669255,
0.005578857,
-0.020442894,
0.009298095,
0.019732622,
-0.00963386,
0.0012897878,
0.00024476103,
0.0016642944,
0.028849922,
0.031949285,
-0.021204822,
-0.0078065256,
-0.012765509,
-0.007696756,
0.032724127,
0.010854234,
0.044914965,
0.046051398,
0.044630855,
0.00020067177,
0.010899433,
0.03176849,
0.013753432,
-0.011822786,
0.0061858157,
0.011248112,
0.0015892317,
0.017847177,
-0.009582203,
-0.014657414,
0.005088124,
0.039077826,
0.011609704,
0.0108736055,
0.013934228,
0.0064860666,
0.008181032,
-0.009265809,
0.001930646,
-0.016452461,
0.012197292,
0.008749248,
0.0013761503,
-0.035255276,
0.0019790737,
0.014709069,
0.011570962,
-0.019474342,
0.008355372,
0.0006662827,
0.017459756,
-0.0070510553,
-0.034609575,
0.010460356,
-0.0009822727,
-0.008891303,
-0.007599901,
-0.0049363845,
-0.03189763,
-0.010789664,
-0.026912818,
-0.003725695,
0.0008426398,
-0.00009362665,
0.0133401835,
0.0055627143,
-0.0067217476,
0.013675948,
0.025143597,
-0.008368285,
0.03161352,
-0.03153604,
-0.014799467,
0.01196484,
-0.005707997,
0.005975963,
-0.01962931,
-0.020791573,
-0.011796958,
0.016491205,
-0.004833072,
-0.010899433,
-0.03378308,
-0.00131723,
0.0027071016,
-0.0026796593,
0.0152902,
-0.02980556,
-0.0072512226,
-0.019332288,
0.0016868939,
0.0030606228,
0.0141925085,
-0.012190836,
-0.010524927,
-0.017059421,
-0.009252896,
-0.022909472,
-0.0056853974,
0.013378926,
0.0025392193,
0.006321413,
0.0005331069,
-0.024898231,
0.017240217,
-0.011428908,
-0.002479492,
-0.016129611,
-0.0052527776,
0.018970696,
-0.0038548352,
0.0014665484,
0.015780933,
-0.013353097,
-0.014153766,
-0.015019006,
0.017989231,
-0.031303585,
-0.022379998,
0.013314355,
-0.023361463,
-0.028126737,
-0.021114424,
0.0125782555,
-0.0049557555,
0.023774711,
-0.029624764,
-0.023232322,
-0.022470396,
-0.011054401,
-0.0054884586,
0.009252896,
-0.0008991387,
-0.021204822,
-0.017485583,
0.010357045,
-0.009478891,
0.0022599536,
0.029908871,
-0.03182015,
-0.011357881,
0.009420778,
-0.0017676066,
0.00909147,
0.0059598205,
0.000926581,
0.005795167,
0.0050138687,
-0.013985884,
-0.027636005,
0.0043939953,
-0.0063375556,
0.04390767,
0.015186888,
0.046154708,
-0.016336236,
-0.028385017,
-0.00052059646,
0.028178392,
-0.0050719813,
-0.024226703,
0.019990904,
-0.020404153,
0.02835919,
0.022121716,
0.013766346,
0.01246203,
-0.00055126724,
0.0095111765,
0.0076257293,
-0.004678104,
-0.029676419,
-0.020417066,
-0.02075283,
-0.033679765,
0.011551592,
-0.0031397212,
-0.006243929,
0.0013519365,
-0.016207095,
0.003561041,
0.025879698,
0.0041195727,
-0.01226832,
-0.010298931,
0.010983374,
0.006902544,
-0.003971061,
-0.007057512,
-0.0133401835,
-0.007935666,
-0.00863948,
-0.01609087,
0.010434529,
0.020649519,
0.017433928,
0.018040886,
-0.007871095,
-0.0050913524,
0.012939849,
-0.038406298,
-0.012965676,
0.017873004,
-0.016865712,
-0.0062148725,
0.022664106,
0.014980264,
-0.008755706,
-0.019474342,
-0.007955037,
-0.0025618188,
0.016142525,
-0.009562832,
-0.022302514,
-0.0079808645,
-0.026409172,
0.026060494,
-0.028023424,
0.022793246,
0.024007164,
0.0030315663,
0.0020791574,
0.0042454842,
0.009168955,
0.015083576,
0.0036675818,
0.034635402,
-0.018996524,
-0.01872533,
-0.012326432,
0.0009491805,
-0.01634915,
-0.02226377,
0.031355243,
0.0032010628,
0.015548481,
0.0020178156,
-0.016788227,
-0.01490278,
-0.0051882076,
0.027300239,
-0.034093015,
-0.0021275848,
-0.026318774,
-0.020442894,
0.035126135,
-0.026964474,
0.022689935,
0.014489531,
-0.005892022,
0.009149583,
-0.038148016,
-0.014011712,
0.016232925,
-0.016258752,
0.023400204,
0.009304551,
-0.010550755,
-0.008219774,
-0.025363136,
0.0012413602,
0.0037160094,
-0.012707396,
0.033318173,
0.012010039,
-0.0014875337,
0.031303585,
-0.024407499,
0.004836301,
-0.0128752785,
-0.011951926,
-0.008264973,
-0.06183233,
-0.008529711,
0.016710743,
0.02267702,
-0.02662871,
0.001993602,
-0.0071156253,
0.01077675,
-0.022883644,
-0.0064860666,
0.00013761503,
-0.0070897974,
-0.009846941,
0.0025941038,
0.009788828,
0.006773404,
-0.0030396376,
0.005963049,
-0.0028652982,
-0.011919641,
-0.009562832,
0.020094216,
0.010208533,
0.032853268,
-0.01991342,
-0.003790265,
-0.0221992,
-0.03378308,
0.008994616,
-0.013520979,
-0.04191891,
-0.02714527,
-0.009672602,
0.013947142,
0.010989832,
-0.015367684,
0.025789298,
-0.0015876174,
0.023555173,
-0.01097046,
-0.0326983,
0.015729276,
0.008155204,
0.0022179831,
0.011422451,
-0.016103784,
0.011958383,
-0.0022228258,
0.004658733,
0.021773038,
-0.0010234361,
0.007328707,
-0.044062637,
-0.012494314,
-0.0024116933,
-0.019577656,
0.00056458486,
0.0060437615,
-0.0134693235,
-0.0036126971,
0.009013986,
-0.0059049358,
0.016336236,
-0.004506993,
-0.0032575617,
-0.0016077956,
-0.017627638,
-0.008536167,
-0.02135979,
-0.015135232,
-0.00068484666,
-0.0055433433,
-0.005220493,
0.02187635,
0.026280032,
-0.0034093014,
-0.016232925,
-0.011357881,
-0.04091162,
-0.017485583,
0.005210807,
0.011758216,
0.018015059,
0.009272267,
-0.0038742062,
0.034325466,
-0.020843228,
-0.003783808,
-0.014024626,
-0.021540586,
-0.009704886,
-0.01663326,
0.022664106,
0.012914021,
-0.028669126,
-0.01027956,
0.011377252,
-0.0028991976,
-0.008432856,
0.0037192379,
0.01397297,
0.00382255,
-0.02572473,
0.028462501,
0.0040033464,
-0.012810708,
-0.019823022,
-0.023581002,
-0.0061470736,
-0.00083618285,
-0.008981701,
-0.01984885,
-0.0011291697,
-0.015238544,
0.012481401,
0.0016772085,
-0.013140016,
-0.025569761,
0.0065441797,
-0.0201717,
-0.02252205,
0.04602557,
0.020249184,
-0.0028217135,
0.009491805,
0.008917131,
-0.006379526,
-0.0009346522,
-0.021850523,
-0.005136552,
0.0067217476,
0.011222283,
-0.021708468,
0.003561041,
-0.0013301441,
-0.010318303,
-0.009898596,
-0.0074643036,
-0.019461429,
-0.016969023,
0.031975113,
0.006973571,
-0.010686352,
0.003246262,
0.010595954,
-0.01693028,
-0.017162733,
-0.037863906,
-0.0015900388,
-0.025518104,
0.008045435,
0.015057748,
0.0044069095,
-0.0005440031,
0.0033479598,
0.015625965,
-0.0011614547,
0.019732622,
0.18875133,
-0.009478891,
-0.0007239923,
0.035100307,
0.007722584,
0.03760563,
0.028849922,
-0.002652217,
0.007819439,
0.014980264,
0.030425433,
0.014980264,
-0.019422688,
0.003354417,
0.022431653,
-0.013036704,
-0.028178392,
-0.020959456,
-0.0075224168,
-0.0014374919,
0.017227303,
0.0017159504,
0.0032172054,
-0.0059533636,
0.0025537475,
-0.0025004772,
-0.016465375,
-0.0022131403,
0.03889703,
-0.023258151,
-0.011758216,
-0.010369958,
-0.0028459274,
-0.0012324818,
-0.01077675,
0.0045941626,
0.0030460947,
-0.008781534,
0.006269757,
-0.006689463,
-0.010034194,
0.0038257786,
-0.057544876,
-0.0033608738,
0.013650119,
0.016077956,
-0.010189163,
-0.02492406,
-0.008051892,
0.0033608738,
-0.0416348,
-0.001259117,
0.024885317,
0.030373776,
-0.009272267,
0.0049137846,
0.02688699,
-0.013404753,
-0.010350588,
0.01760181,
-0.0018596189,
-0.0044843936,
-0.013275613,
0.007412648,
-0.022186287,
0.025272738,
-0.020610776,
-0.00034746787,
-0.0024940202,
-0.002684502,
-0.0062051867,
-0.01766638,
-0.009272267,
0.022302514,
0.014967349,
-0.0032575617,
0.01270094,
0.008975244,
0.008419941,
-0.020313755,
-0.0046135336,
-0.009033358,
0.005401289,
0.021630984,
0.0004071952,
-0.010505555,
0.0065248087,
0.01284945,
0.0017676066,
-0.0007235887,
-0.004135715,
-0.029753903,
0.007942122,
0.0022195973,
0.046335507,
0.0063827545,
-0.018841555,
0.017976316,
-0.0046329047,
0.00027644075,
-0.028049253,
0.07128539,
-0.00077241985,
0.015587223,
0.0035642697,
0.008710506,
-0.025569761,
0.02252205,
-0.003118736,
0.0032882325,
0.008549081,
-0.017343529,
0.021592243,
-0.008645937,
0.0003886313,
0.006095418,
0.0105765825,
-0.036959928,
0.0016917366,
0.0036126971,
0.010479728,
-0.044630855,
-0.001246203,
0.02835919,
-0.012862365,
-0.0010710566,
-0.03760563,
-0.008729878,
-0.0027167872,
-0.026706195,
0.023141924,
-0.01371469,
-0.0036062403,
0.015729276,
0.016258752,
-0.0018305624,
0.010137506,
-0.0375798,
0.02977973,
0.005088124,
0.0104926415,
-0.009291638,
0.014605757,
0.0075224168,
-0.0032349622,
0.00087653915,
-0.010027737,
0.00375798,
-0.0017417785,
-0.0025085486,
-0.019577656,
0.00054279243,
0.013353097,
0.011874442,
0.0072189374,
-0.01725313,
0.0064118113,
-0.04721366,
-0.010563669,
0.00963386,
-0.005214036,
-0.0021065995,
0.040162604,
-0.017382272,
-0.0137276035,
0.012423288,
-0.16003054,
0.02511777,
0.026137978,
-0.035668526,
0.025711814,
0.011893813,
0.034325466,
0.02226377,
-0.013998798,
-0.0041841427,
0.019655138,
0.0017789063,
-0.04721366,
-0.012804251,
0.020727003,
-0.0013212657,
-0.010738008,
0.021178994,
0.02312901,
0.03138107,
0.017550154,
-0.017575981,
0.009530547,
-0.005184979,
0.015432254,
-0.0007348885,
0.011344967,
-0.021721382,
0.0017224075,
-0.0057822526,
0.020636605,
0.009007529,
0.03153604,
-0.012384546,
-0.0024246073,
-0.011842157,
-0.022935301,
0.009963167,
0.0030606228,
-0.00060938037,
0.049383216,
0.006831517,
0.011654903,
0.0073157926,
-0.023593916,
0.023206495,
0.02483366,
-0.016969023,
0.025789298,
-0.004581249,
0.023555173,
-0.002760372,
0.023581002,
0.013043161,
-0.0039742896,
0.003841921,
-0.014760725,
-0.00024395392,
0.014786554,
0.011435365,
-0.02714527,
-0.03755397,
0.023890939,
-0.01859619,
0.007935666,
-0.033731423,
-0.03166518,
0.012791337,
-0.018131284,
0.015186888,
-0.028901577,
0.00056095276,
-0.0031590923,
-0.015910074,
0.029392311,
0.011157714,
-0.047084518,
-0.0064150398,
-0.010944633,
-0.004691018,
-0.0016885082,
-0.022095889,
-0.0004903292,
-0.025892612,
-0.029340655,
0.02241874,
0.025479363,
0.0117259305,
-0.0025650472,
-0.01818294,
0.028694954,
-0.026938647,
-0.03096782,
-0.013830916,
0.01693028,
0.018273339,
-0.004429509,
0.014851123,
-0.0153418565,
-0.032646645,
0.034170497,
-0.02511777,
-0.04150566,
-0.0063762977,
0.034738716,
-0.00018130074,
-0.0023083813,
-0.015057748,
0.027739316,
-0.007812982,
0.005362547,
0.011693645,
0.013204586,
0.020584948,
-0.0036352968,
0.002615089,
-0.0052882913,
-0.0096403165,
-0.00814229,
-0.026938647,
0.017149819,
0.014670327,
0.0017143362,
-0.0017740636,
0.0037160094,
0.0060179336,
-0.111887075,
-0.017240217,
-0.0057499674,
0.036469195,
0.01725313,
0.03228505,
-0.015109404,
0.0036675818,
-0.00009009547,
0.03781225,
-0.012862365,
0.003764437,
-0.012345804,
0.0050719813,
0.042280503,
-0.01937103,
-0.0057435106,
-0.025569761,
-0.0520435,
0.016775312,
-0.0038774346,
-0.0010460357,
0.0049234703,
-0.023710141,
-0.0045425068,
0.009472434,
-0.01583259,
0.015019006,
0.020533292,
0.009666144,
-0.02518234,
-0.003841921,
0.012965676,
-0.019216063,
-0.02248331,
0.0100664785,
-0.00451345,
-0.03977518,
0.026176719,
-0.022367083,
0.010350588,
0.004397224,
0.028514158,
-0.016387893,
0.028849922,
-0.038948685,
-0.02649957,
0.020197527,
0.006295585,
0.008781534,
-0.019500172,
0.00090398145,
-0.024175046,
0.016245838,
0.006498981,
-0.019164406,
-0.007929209,
0.010176248,
0.0032688614,
-0.014153766,
-0.031355243,
0.0056853974,
-0.019125665,
0.016336236,
0.02004256,
-0.023012785,
0.008103548,
-0.00048508288,
0.007038141,
-0.027455207,
-0.0019774593,
-0.010815492,
-0.0031413354,
0.0015932673,
-0.018131284,
0.0059856484,
0.0141925085,
-0.02977973,
0.022405826,
-0.012300605,
0.0042939116,
-0.013792174,
0.008516797,
0.00017131255,
0.006563551,
0.018170027,
0.013611377,
0.005446488,
0.004364939,
-0.027532691,
-0.00054723164,
0.015122318,
0.020946542,
-0.015651792,
0.0006626507,
-0.005220493,
0.020081302,
0.010072936,
0.033602282,
0.0063956687,
-0.032646645,
-0.019693881,
-0.062038954,
0.027920112,
0.020275012,
-0.0073803626,
-0.0083618285,
0.000013922929,
0.026654538,
-0.0065248087,
-0.00044432303,
0.010221447,
-0.005304434,
0.026551226,
0.009859854,
-0.00451345,
-0.018996524,
-0.0014035926,
0.0019984446,
0.015729276,
0.03998181,
0.046051398,
0.003790265,
0.012494314,
0.02807508,
0.0005553029,
-0.015780933,
-0.0023874796,
-0.002794271,
0.006773404,
-0.023839282,
-0.005017097,
0.019952161,
-0.0036352968,
-0.017175646,
-0.008019607,
0.0023245236,
-0.006547408,
-0.024330014,
0.017976316,
0.012384546,
0.0046038483,
-0.0017692208,
-0.009872769,
0.018454134,
0.009046271,
-0.010460356,
-0.002051715,
-0.05289583,
0.01477364,
0.0034093014,
0.009846941,
-0.012423288,
-0.0003317289,
0.0026054035,
-0.01120937,
0.008975244,
-0.0057112253,
0.0049912687,
-0.00934975,
-0.016801141,
-0.020675346,
0.00037834045,
0.03941359,
-0.0008708892,
0.019125665,
-0.009440149,
-0.039000344,
-0.014102111,
-0.021153165,
-0.008006693,
0.005775796,
-0.022986956,
0.0016521876,
-0.00029076723,
-0.0013761503,
0.001712722,
-0.0110866865,
-0.0024052362,
-0.0043100542,
-0.00138745,
0.022212116,
-0.012132722,
-0.0024197646,
-0.007664471,
0.030941993,
0.026189633,
0.042616267,
0.010815492,
0.010434529,
0.00369341,
0.014954436,
0.00820686,
0.015922988,
0.0067346618,
0.009007529,
0.021824695,
-0.0010920418,
0.0025069343,
0.017718036,
0.001004065,
0.016194182,
0.009472434,
-0.008755706,
-0.01166136,
-0.012965676,
-0.015522652,
-0.006812146,
-0.033137377,
-0.01641372,
-0.046516303,
0.0139084,
0.02794594,
-0.002812028,
0.020068388,
-0.0025133912,
-0.007490132,
0.015871331,
0.025091942,
0.019435601,
-0.001924189,
0.03440295,
0.0064666956,
0.03708907,
0.033705592,
0.01926772,
0.026008837,
-0.011267483,
0.011654903,
-0.007038141,
0.028049253,
-0.00745139,
0.0033479598,
-0.021049853,
-0.028178392,
-0.011913184,
-0.013430581,
-0.028178392,
0.034041356,
0.017433928,
-0.0042454842,
0.07273176,
-0.012991505,
-0.03835464,
0.00043907668,
-0.0072964216,
0.017485583,
0.013805088,
0.023800539,
0.007328707,
-0.014864038,
-0.003094522,
-0.0041905995,
0.02630586,
-0.04705869,
-0.016207095,
0.031871803,
0.0011638761,
0.0369341,
-0.010247275,
-0.008252059,
0.037399,
-0.02755852,
0.017653465,
0.016258752,
-0.029340655,
-0.014657414,
0.026008837,
0.010221447,
0.006231015,
-0.03375725,
-0.012223121,
0.016672,
-0.023025699,
-0.020132957,
0.030347949,
-0.008155204,
0.0020371866,
-0.035151962,
0.024730349,
-0.0038580636,
-0.010382872,
0.024136305,
-0.012035867,
-0.03166518,
-0.03311155,
-0.033705592,
-0.020675346,
-0.01673657,
0.005617599
] |
We propose that the microRNA milieu, unique to each cell type, productively dampens the expression of thousands of mRNAs and provides important context for the evolution of all metazoan mRNA sequences. For genes that should not be expressed in a particular cell type, protein output is lowered to inconsequential levels. For other genes, dosage is adjusted in a manner that allows for customized expression in different cell types while achieving a more uniform level within each cell type. In these ways, the microRNAs add an extensive layer of gene control that integrates with transcriptional and other regulatory processes to expand the complexity of metazoan gene expression. | [
-0.03526756,
-0.031211395,
-0.011319069,
-0.016632909,
-0.0043096747,
0.011793166,
-0.004003487,
0.015118431,
-0.03068462,
-0.008487656,
-0.00096547906,
-0.0027573358,
0.017752305,
-0.011391501,
0.009165878,
0.004062749,
0.02593048,
-0.0013391598,
0.024416003,
0.0059821843,
-0.022098195,
0.028735554,
-0.025430044,
-0.03215959,
-0.017778642,
0.02446868,
0.017923506,
-0.041009404,
-0.0003035127,
-0.04356426,
0.004573062,
0.0038652087,
-0.015223786,
-0.014196576,
-0.017344054,
0.0034931742,
-0.006894163,
-0.010548661,
0.028393151,
-0.0051360526,
0.027128892,
0.0028972602,
-0.0030223692,
0.009185632,
-0.0034372043,
-0.0038915474,
0.011029343,
0.0076645706,
0.008290116,
0.0045203846,
0.021031477,
-0.0077304174,
-0.017146513,
-0.009040769,
-0.02010962,
0.016922634,
-0.024244802,
0.013959527,
-0.007381429,
0.002296408,
-0.0035590208,
-0.009481943,
-0.024192125,
0.025561737,
-0.013854172,
0.022032348,
0.0042010276,
0.003038831,
0.02154508,
-0.019437984,
0.026207037,
0.0035721902,
0.002016559,
0.017923506,
0.004253705,
-0.039455418,
-0.011068852,
0.013386659,
-0.004253705,
-0.005567349,
0.011806336,
0.004312967,
0.010779126,
0.006666991,
0.0188717,
-0.013044256,
0.012003876,
0.01027869,
0.01390685,
-0.012978409,
0.022427429,
0.032080572,
0.013643462,
0.020425685,
-0.003677545,
0.008230853,
0.0067756386,
0.03900766,
-0.011259807,
-0.020280823,
-0.03050025,
0.03376625,
-0.022058686,
-0.012550405,
-0.02511398,
0.011589041,
0.015658375,
-0.033107784,
0.01172732,
-0.019701371,
-0.023112236,
0.03668985,
-0.003017431,
-0.0444071,
0.02508764,
0.033160463,
0.017027989,
0.019780386,
-0.01576373,
-0.001167958,
0.010910819,
0.026207037,
0.005824152,
-0.02718157,
0.028524844,
0.012109231,
0.011167621,
-0.006311418,
-0.016092964,
-0.0024857176,
0.027761022,
-0.004352475,
0.0057714744,
0.02965741,
-0.032818057,
0.0134986,
-0.01929312,
-0.004378814,
-0.004141765,
-0.031237734,
-0.00067287224,
0.040535305,
-0.034635432,
-0.0011663119,
-0.008059652,
0.010041641,
0.025192995,
-0.0022256228,
0.014552148,
0.004029826,
0.0027063044,
-0.018568804,
0.025206165,
-0.016343182,
0.009942871,
0.0057253814,
0.0014041836,
0.026167529,
-0.00985727,
0.009198802,
0.022954203,
-0.0016346475,
0.02532469,
0.027761022,
0.020504702,
0.019398475,
0.004994482,
0.00034960549,
-0.0009185632,
-0.0032676486,
0.005327008,
0.021031477,
-0.026628457,
0.011055682,
-0.009205386,
0.013603955,
-0.0092580635,
0.025245672,
-0.012596497,
-0.00725632,
-0.0014617995,
-0.011674643,
-0.0002804663,
-0.0024544403,
-0.015315971,
0.0076250625,
0.01867416,
0.011674643,
0.018687328,
-0.011832675,
-0.014697012,
0.003934348,
0.024165785,
0.009732161,
-0.6384508,
-0.02116317,
0.020228146,
-0.024165785,
0.0048101107,
0.0076645706,
-0.005847198,
-0.015579359,
-0.0010222719,
0.027102554,
-0.035478268,
-0.0015054231,
0.013801495,
-0.042010274,
-0.01991208,
-0.04145716,
-0.016224658,
-0.017607441,
0.01701482,
0.001919435,
-0.034477398,
0.0037730231,
0.011200545,
0.016132472,
-0.01514477,
-0.005633196,
0.014275592,
0.00011728966,
-0.013999036,
0.01369614,
-0.015513512,
0.022941034,
-0.032054234,
-0.015368649,
0.052967187,
0.0028297673,
-0.009679483,
0.0323703,
-0.0054488247,
0.011556118,
-0.03605772,
-0.0026025958,
0.011799751,
0.0037005916,
-0.009317325,
0.008889321,
0.002786967,
-0.0096531445,
0.010146996,
-0.002749105,
-0.013841003,
0.016580231,
-0.025351027,
-0.0056924582,
-0.0036512064,
-0.0009712407,
0.02612802,
-0.013452507,
0.01214874,
0.004856203,
-0.005748428,
0.016145641,
-0.008112329,
-0.0055838106,
0.004783772,
0.013893681,
-0.008895906,
0.004852911,
0.0029696918,
0.0113059,
0.0128533,
0.028814571,
-0.016066626,
0.00963339,
-0.0082967,
0.0494378,
0.0039475174,
-0.003116201,
0.007710663,
0.025456382,
0.006232402,
-0.011200545,
-0.024178954,
-0.0012527358,
0.01535548,
-0.00029054913,
-0.0134986,
0.025166657,
0.013761987,
0.00538627,
-0.00012480031,
0.011016174,
-0.0044742916,
-0.039903175,
-0.028972603,
0.018753177,
-0.004033118,
0.010522323,
0.031606477,
-0.03250199,
-0.026391407,
0.003723638,
0.01026552,
0.00069015706,
-0.009600467,
0.000954779,
-0.041193776,
0.0072892434,
0.01929312,
-0.019437984,
0.008533749,
0.02739228,
0.00892883,
-0.0036907145,
-0.01677777,
-0.027734684,
0.0148023665,
0.019609185,
-0.013841003,
-0.03397696,
-0.0013572677,
-0.005491625,
0.0017877413,
0.010614509,
0.011088605,
0.008606181,
-0.004526969,
-0.014565318,
-0.010575,
0.0013630292,
0.013175949,
-0.0034503737,
0.01950383,
-0.022295736,
0.023625841,
0.011332239,
0.022243058,
0.010120657,
0.0032018018,
-0.019727709,
-0.019279951,
-0.022098195,
-0.0011786582,
-0.021729453,
0.0033598342,
-0.009686068,
-0.018305417,
-0.012800623,
0.0234283,
-0.018134216,
0.013083764,
0.0008045659,
0.012240925,
0.016474877,
0.015078923,
0.0058373213,
-0.039481755,
-0.024811083,
-0.008685197,
-0.008309869,
-0.0032462485,
0.013788326,
-0.014328269,
-0.0069007473,
-0.027840039,
-0.027550312,
-0.01172732,
0.0075855544,
0.003144186,
-0.035004172,
0.02321759,
-0.015289633,
-0.0072036427,
0.017186021,
0.0072629047,
0.0025795493,
-0.012155324,
0.023915567,
-0.018687328,
-0.024771577,
-0.010851556,
-0.02549589,
-0.021387048,
-0.013867342,
0.035794333,
0.029499378,
0.048199877,
-0.014064882,
0.03748001,
0.047199003,
-0.0054817484,
0.0050866674,
-0.0278137,
0.03690056,
0.014249253,
-0.03613674,
0.021044645,
0.001784449,
0.0067328378,
0.02262497,
0.024574036,
-0.025245672,
-0.012774284,
-0.018344926,
0.0015959624,
-0.019398475,
-0.007816019,
-0.00082925847,
0.0026667963,
0.0085139945,
0.0026322268,
0.0068019773,
-0.0042701666,
-0.015236955,
0.023125404,
0.011266392,
0.0038355775,
-0.0071048723,
-0.023691688,
-0.0050471593,
0.00026379884,
0.0055245487,
0.0002074175,
-0.008737874,
-0.015842747,
0.0037071763,
-0.0049088807,
-0.0059097526,
-0.011082021,
-0.010858142,
0.004507215,
-0.0027227663,
0.0002633873,
-0.0028001363,
0.015210616,
0.012497728,
-0.0012420358,
-0.009271233,
0.021452896,
0.011654888,
-0.021650435,
-0.00627191,
0.008428394,
-0.0073024128,
0.008639104,
-0.021703113,
0.026062174,
0.008224268,
-0.0041944426,
-0.02450819,
-0.0086654425,
0.002143314,
-0.013854172,
-0.020886613,
0.0014535687,
-0.02720791,
-0.0019046194,
-0.0025038256,
0.042062953,
0.005781351,
-0.009514866,
-0.00840864,
0.0115363635,
-0.02095246,
-0.017778642,
0.017475748,
0.047146328,
-0.0044150297,
-0.021953331,
0.0072694896,
-0.021426557,
-0.005172268,
0.007282659,
-0.024192125,
0.013406414,
-0.005639781,
0.0023490854,
0.022519615,
0.024007753,
0.010403799,
0.0013202289,
-0.013788326,
0.023941906,
0.010495984,
-0.008533749,
-0.013669801,
-0.036847882,
0.004566477,
-0.003819116,
0.0040199487,
0.017383562,
0.008935414,
-0.016751433,
-0.003694007,
0.0027639205,
-0.00445783,
0.020675903,
-0.039113015,
0.011279562,
-0.0036215754,
0.022361582,
-0.0020428977,
0.0022437305,
-0.0062192325,
0.033660896,
0.0023145159,
0.0047014635,
-0.0001980549,
-0.013189119,
-0.011753659,
-0.024797915,
-0.013538107,
0.01369614,
-0.017594272,
0.017949844,
-0.007960881,
0.00995604,
0.009040769,
0.026799658,
0.011483686,
-0.006423358,
-0.034635432,
0.018134216,
0.0010198028,
0.02133437,
0.037216626,
-0.020715412,
0.025008624,
-0.01884536,
0.021663606,
-0.02136071,
-0.005929507,
0.031474784,
-0.016632909,
-0.013136442,
0.023546824,
-0.013511769,
-0.022243058,
0.0027063044,
0.022282565,
0.0071048723,
-0.02720791,
-0.02344147,
0.005896583,
0.025996327,
0.024613544,
0.02573294,
0.035557285,
0.0077896793,
-0.002767213,
-0.0048759575,
0.007862111,
0.004102257,
-0.008125498,
0.01514477,
0.021979671,
0.0011638426,
0.0092580635,
-0.0037664385,
-0.012366034,
0.015447665,
-0.0032232022,
0.016132472,
0.0020330208,
0.0005555826,
0.027444957,
0.016092964,
-0.013893681,
-0.01006798,
-0.00891566,
-0.018331757,
0.029525716,
-0.020056942,
-0.020478362,
0.023401963,
-0.01635635,
0.010647432,
-0.009811177,
0.00466854,
-0.0074736145,
-0.008836644,
0.02594365,
-0.00021132716,
-0.017357223,
-0.008698366,
-0.021084154,
0.0017482332,
-0.012056554,
-0.0070587797,
-0.02054421,
0.007967466,
-0.014657503,
-0.014038543,
-0.018226402,
0.017791811,
-0.030342218,
-0.030526588,
-0.012161909,
0.02032033,
0.050043587,
0.0027573358,
-0.026312392,
-0.0045006303,
0.019135088,
-0.0018321879,
-0.021479234,
0.006245571,
-0.034319367,
0.0043722293,
-0.007638232,
-0.012471389,
-0.02055738,
-0.024547696,
-0.021505574,
0.00090539386,
0.003954102,
0.025337858,
-0.0007601193,
-0.019424813,
0.005998646,
0.005218361,
0.023388792,
-0.009975794,
-0.0141043905,
-0.017870829,
-0.012300187,
-0.02282251,
-0.031869862,
-0.0056002727,
-0.036163077,
0.008421809,
0.008454733,
-0.017370393,
-0.009528035,
0.011700981,
-0.010285274,
0.014591657,
0.024165785,
0.016501214,
0.024929607,
0.0077633406,
0.019253612,
-0.008573256,
-0.0056924582,
-0.011233469,
-0.023862889,
0.016369522,
0.008672027,
-0.010285274,
0.025640754,
-0.015474004,
-0.021466065,
-0.03200156,
0.008540333,
-0.018410772,
0.05207167,
-0.006248864,
-0.027523974,
-0.006907332,
-0.013037671,
0.0062653255,
0.005820859,
-0.013669801,
-0.007993804,
-0.018898038,
0.011964369,
-0.010120657,
-0.017870829,
0.01234628,
-0.03608406,
0.017818151,
0.01214874,
0.019569676,
0.012188247,
0.0069402554,
0.008783966,
-0.0149999065,
-0.00456977,
-0.008797136,
-0.026628457,
0.0059360913,
-0.011161037,
0.044328082,
0.012372619,
0.026207037,
0.0065517593,
-0.0012000584,
0.01947749,
0.02262497,
0.00212356,
0.014960399,
0.017357223,
-0.009146124,
-0.0013350444,
0.029789103,
0.009877024,
0.022295736,
-0.010061395,
0.01223434,
0.0027935517,
-0.013511769,
-0.00871812,
0.017396731,
-0.0066801603,
-0.04082503,
0.02175579,
-0.028972603,
0.008823475,
-0.03258101,
-0.014486302,
0.018937547,
0.0041911504,
0.0219665,
-0.0040923804,
0.011470517,
-0.0035590208,
0.024323817,
-0.013959527,
0.016488045,
-0.017515255,
0.0044808765,
-0.017001651,
-0.027761022,
0.010469645,
0.010963497,
0.012510897,
-0.0003802654,
-0.031606477,
0.014301931,
-0.005913045,
-0.034319367,
-0.0042109047,
-0.000301455,
-0.008323039,
-0.03047391,
-0.016250996,
-0.009784838,
-0.03279172,
0.0065649287,
0.013050841,
-0.0010749494,
0.0024231633,
0.0002668854,
-0.011240053,
0.047172666,
-0.0036709604,
0.018805854,
-0.026470425,
0.007671155,
0.018726837,
-0.010864726,
-0.012405542,
-0.0294467,
0.014973568,
-0.01621149,
0.04003487,
0.0037993619,
-0.014170237,
0.000052240197,
0.018134216,
0.006153386,
0.009528035,
-0.028972603,
0.0012469742,
-0.006686745,
-0.0030240156,
-0.0096531445,
-0.0035063436,
-0.013564446,
0.004042995,
-0.0108383875,
0.011483686,
-0.0007465384,
0.001553985,
-0.0056562424,
0.012379203,
0.022519615,
0.010522323,
0.000766704,
0.0036643757,
-0.023889229,
-0.005422486,
-0.0036907145,
-0.009040769,
-0.0049088807,
0.016290504,
0.00017758066,
0.0060842466,
0.019582845,
-0.00042882745,
-0.0000588506,
-0.008487656,
-0.011674643,
0.041852243,
-0.029130636,
-0.002546626,
0.009402927,
-0.008257192,
0.008487656,
0.0012321587,
-0.004918758,
-0.005893291,
-0.021729453,
0.006393727,
0.027523974,
0.026654795,
-0.011121529,
-0.011062266,
-0.013630293,
-0.0000028406089,
-0.010673771,
-0.023322945,
0.01991208,
-0.008257192,
0.00033705344,
0.01077254,
0.026444085,
0.018937547,
0.01701482,
-0.0033153878,
-0.021768961,
0.030026153,
-0.00021811761,
0.043195516,
0.0032544793,
-0.030421233,
-0.024600374,
0.016540723,
-0.010193089,
-0.04132547,
0.0080728205,
-0.053072542,
-0.025890972,
-0.0049154656,
-0.017133344,
0.0108383875,
0.007098288,
-0.021624098,
-0.0065550515,
0.0054060244,
0.024152616,
-0.0043458906,
0.014064882,
0.010403799,
-0.026114851,
-0.0074999533,
0.0071575497,
0.017949844,
-0.009370003,
0.00017809508,
-0.009475358,
-0.0030306003,
-0.019780386,
-0.01926678,
-0.019069241,
0.01576373,
-0.0041318885,
-0.0034931742,
-0.004293213,
-0.02115,
-0.011556118,
0.009238309,
0.0035359745,
-0.0065813903,
-0.0049352194,
0.020623226,
0.019187765,
0.0006769877,
-0.012293602,
-0.003568898,
-0.010950327,
-0.027286924,
-0.028103426,
-0.008244023,
-0.003519513,
0.03566264,
0.0023457932,
0.0038948397,
-0.01783132,
0.01947749,
-0.042616066,
-0.029973475,
0.027971731,
0.013426168,
0.0043656444,
0.004128596,
0.019016564,
-0.018766345,
-0.0039409325,
0.010910819,
0.006887578,
-0.017488917,
0.0015218848,
0.021716284,
0.0074011832,
0.0057155043,
-0.028445829,
0.0008374893,
0.042062953,
-0.019029733,
-0.029156974,
0.018358095,
-0.03300243,
0.017936675,
-0.023704857,
0.012089477,
-0.0038553316,
0.006357511,
0.030526588,
-0.035372917,
-0.007486784,
0.014367777,
-0.006038154,
-0.027945394,
-0.0002884914,
-0.0075658,
0.018832192,
0.011398085,
-0.0053335926,
-0.015803238,
0.017265039,
0.0029219529,
0.021136831,
0.013735648,
0.0030322464,
0.017686458,
0.027234247,
-0.0050866674,
-0.024850592,
-0.016764602,
-0.00053953246,
0.008125498,
0.009053938,
0.021005137,
-0.020438856,
-0.00026894314,
-0.0004407622,
-0.018555636,
-0.0038421622,
0.010581585,
-0.012405542,
-0.00051772065,
-0.021505574,
0.0029976768,
-0.0149999065,
-0.00028931448,
0.00808599,
-0.0033236186,
-0.0196882,
0.005317131,
-0.0046257395,
0.00445783,
0.016830448,
0.0070061022,
0.0036907145,
0.0031573554,
-0.020649565,
0.0033911115,
-0.011911691,
0.031290412,
0.18236937,
-0.025192995,
-0.006433235,
0.011905106,
-0.008474487,
-0.023191253,
-0.0008346085,
0.0037071763,
-0.0014264069,
0.00073089974,
0.005139345,
0.016290504,
0.0015745622,
0.00004498676,
0.01600078,
-0.036426462,
-0.02136071,
-0.011984122,
-0.017963015,
0.0059657223,
-0.0028577521,
-0.011226884,
0.003213325,
0.0010889419,
0.047594085,
0.005402732,
-0.017330885,
0.007572385,
0.016119303,
-0.0020198515,
-0.0348198,
0.0017762181,
-0.0026289346,
-0.006113878,
0.027234247,
0.019227274,
-0.009718992,
-0.00324131,
-0.0027754437,
-0.015394988,
0.008612765,
0.008125498,
0.011977538,
-0.0036314523,
0.04082503,
0.0039409325,
-0.0048693726,
-0.011648304,
-0.0032956337,
-0.01596127,
-0.04435442,
0.031843524,
0.008737874,
0.039350063,
0.012392373,
-0.00466854,
-0.0071904734,
0.013630293,
-0.0033911115,
0.019358966,
-0.012510897,
-0.010884481,
-0.020781258,
0.00045187384,
-0.031000685,
0.029947136,
-0.00048397417,
-0.0008922245,
0.020504702,
-0.01926678,
-0.0024132861,
-0.013985866,
-0.017120175,
-0.008658858,
0.00684807,
-0.008731289,
0.032106914,
0.03690056,
0.003568898,
0.038875967,
0.011174207,
-0.007927958,
-0.03487248,
0.019240443,
0.0040561645,
-0.05415243,
0.030948007,
-0.011022759,
-0.01600078,
-0.021716284,
0.010285274,
-0.014947229,
-0.015263294,
-0.004931927,
0.01823957,
0.021926994,
-0.010930573,
-0.018331757,
-0.026391407,
-0.037032254,
-0.04417005,
0.0556274,
0.0024445634,
0.026628457,
0.01597444,
0.00026935467,
-0.00210216,
0.005893291,
0.00034260927,
0.0021778839,
0.0052611614,
-0.022006009,
0.015329141,
-0.017897166,
0.01150344,
0.014565318,
0.04503923,
-0.031606477,
0.041220114,
-0.010660601,
0.0009243248,
-0.0077633406,
0.004464415,
0.022993712,
0.0033285571,
0.012438465,
-0.023204422,
0.026351899,
0.0089090755,
-0.028419489,
0.014657503,
-0.010963497,
0.00017130464,
-0.004737679,
0.008415224,
-0.029288668,
0.031290412,
-0.006001938,
0.0006782223,
-0.006367388,
-0.0029252453,
-0.006867824,
0.010028471,
0.010482815,
-0.0019523584,
-0.009870439,
0.040535305,
0.025192995,
-0.0023853013,
-0.019042902,
-0.0016799171,
-0.0040594568,
-0.009172463,
-0.02032033,
0.0142097445,
-0.0044117374,
-0.01827908,
-0.027550312,
-0.011562702,
0.008355962,
-0.051492218,
-0.0033664189,
0.014644334,
-0.03113238,
-0.0007444807,
-0.013452507,
-0.16424832,
0.0008202045,
-0.0011490271,
-0.024205294,
0.028972603,
0.014328269,
0.0017712796,
-0.0006469451,
0.0007329575,
-0.0137093095,
0.028235119,
-0.007032441,
-0.030105168,
-0.022651307,
0.008158422,
0.017725965,
-0.008961753,
0.040667,
0.008500826,
0.011694396,
0.028472167,
-0.0066307755,
0.002673381,
-0.009534621,
-0.009718992,
0.011654888,
0.00507679,
-0.0020083282,
-0.010950327,
-0.023494147,
-0.009863854,
0.012945486,
0.0141043905,
0.004553308,
0.042431694,
0.014631164,
0.002574611,
0.010607923,
-0.015092093,
0.009587298,
0.0149999065,
0.020241315,
-0.015869085,
0.01556619,
-0.0018749883,
0.023480978,
-0.008935414,
-0.013044256,
-0.0017828027,
-0.0022256228,
0.00632788,
-0.011859014,
0.012214586,
-0.004507215,
0.030842653,
0.023836551,
-0.009863854,
0.029315006,
-0.009620221,
-0.008375716,
-0.010272105,
-0.031158717,
0.0331868,
0.0033532495,
0.020794427,
0.00014620053,
0.0008700012,
0.0072036427,
-0.0107922945,
-0.004286628,
-0.02406043,
-0.0051854374,
0.006423358,
-0.0026453962,
0.014960399,
0.035004172,
0.0068414854,
0.011378331,
-0.004997774,
-0.0010658955,
-0.025759278,
-0.0017218945,
-0.034214012,
-0.006821731,
-0.0061237547,
-0.010028471,
0.023599502,
0.02486376,
-0.013999036,
0.010423552,
0.023836551,
0.009185632,
-0.0015548081,
-0.008606181,
0.030315878,
0.013590785,
0.004526969,
-0.014828705,
-0.018950716,
-0.008421809,
0.02302005,
-0.015632037,
0.0053105466,
0.0001256234,
0.011029343,
-0.0064431117,
-0.0052315304,
0.0016749786,
0.06700573,
-0.01763378,
0.0002642104,
-0.00007500365,
0.012780868,
0.014881383,
0.015408157,
0.027286924,
-0.0030470619,
-0.032528333,
-0.015632037,
-0.0098441,
0.068428025,
-0.009600467,
-0.00027100084,
0.027708344,
0.031211395,
-0.033160463,
-0.14338805,
-0.03221227,
0.018186893,
-0.0028429367,
-0.021650435,
0.024969116,
-0.010100903,
0.030789975,
-0.025206165,
0.031053362,
-0.021202678,
-0.0072629047,
-0.012096062,
-0.02154508,
-0.01909558,
-0.015816407,
0.0012082893,
-0.013656632,
-0.020504702,
0.032080572,
0.011444178,
-0.018134216,
-0.005577226,
0.004573062,
0.006133632,
0.02013596,
-0.0174099,
0.012688683,
0.016540723,
-0.0015424619,
0.0023902399,
-0.0009292633,
0.02054421,
-0.0056562424,
-0.013841003,
-0.0063147107,
0.017607441,
-0.02446868,
0.010390629,
0.0007436576,
0.0005749251,
0.024429172,
0.0034701277,
-0.009080277,
0.009152709,
-0.0017400024,
0.0019177888,
0.0064365272,
-0.011885352,
-0.016316844,
-0.05499527,
-0.013412998,
-0.043959342,
-0.010186504,
0.015394988,
-0.019042902,
0.010212842,
0.026483594,
-0.0063608033,
-0.010825218,
0.0043162596,
0.0008181468,
-0.005139345,
-0.00041462923,
-0.010384045,
-0.015368649,
-0.0052973772,
-0.028182441,
0.029209651,
-0.041825905,
-0.0027244124,
0.014960399,
0.006627483,
-0.0043425984,
-0.0062686177,
0.014328269,
-0.017989352,
-0.022006009,
0.00028231827,
-0.015434496,
-0.0196882,
-0.013248381,
0.028314136,
-0.025825124,
0.013999036,
0.013353736,
0.01848979,
-0.0050899596,
-0.0055443025,
0.00026709118,
-0.01743624,
0.037664384,
-0.013577616,
-0.00725632,
-0.011575872,
0.009870439,
0.0048364494,
-0.010660601,
0.014973568,
-0.00075188844,
-0.006999518,
-0.015724221,
-0.03173817,
-0.0002518641,
-0.021123663,
-0.011753659,
0.007170719,
-0.040798694,
0.00095148664,
0.0043261363,
-0.015934931,
0.015526681,
-0.024705729,
-0.0121750785,
-0.006456281,
-0.009936286,
-0.023559995,
-0.005643073,
0.020293992,
-0.017278207,
0.0047903564,
0.038217496,
-0.018371264,
-0.0038750856,
-0.00256638,
-0.00456977,
-0.01120713,
-0.021808468,
-0.013175949,
0.022229888,
-0.024929607,
-0.01576373,
0.006597852,
-0.022322074,
0.0029482916,
0.015302802,
-0.017910337,
-0.0010823573,
0.015474004,
0.030789975,
0.026905013,
0.021940162,
-0.024982285,
-0.038928643,
0.0030322464,
-0.0016157165,
0.002778736,
0.024784746,
-0.039455418,
-0.0056101494,
-0.0098045925,
-0.021308033,
0.047225345,
0.019609185,
0.00045105076,
-0.02133437,
-0.020214975,
-0.014565318,
0.0050010663,
-0.020267652,
-0.0151974475,
0.0012675514,
0.004754141,
0.02532469,
-0.007361675,
-0.011266392,
-0.017001651,
0.012352864,
-0.016448537,
0.008428394,
0.0022108073,
-0.02175579,
-0.025416875,
0.0021959916,
0.0105947545,
-0.01991208,
0.029894458,
-0.017238699,
-0.022282565,
0.019042902,
-0.009508282,
0.03963979,
0.021795299,
0.022756662,
-0.006782223,
0.011121529,
0.013577616,
0.0045796465,
0.0015902008,
0.0035656055,
0.0011128114,
-0.0056200265,
-0.018819023,
0.015421326,
-0.0032429562,
0.004698171,
0.002941707,
0.007934542,
-0.012372619,
0.016198318,
-0.02531152,
0.020214975,
0.019345798,
0.0026881967,
0.014367777,
-0.025785618,
-0.0036808376,
0.035372917,
-0.031685494,
-0.035609964,
0.009429266,
0.0137093095,
-0.022519615,
0.011088605,
-0.013241797,
0.00021379642,
-0.017488917,
0.04042995,
-0.001553985,
-0.012181663,
-0.013669801,
0.04214197,
0.012484558,
0.006992933,
0.01926678,
-0.016869957,
0.011957783,
0.013788326,
0.0060052304,
-0.035478268,
0.021308033,
0.0015943162,
0.017001651,
-0.0024264555,
-0.019648694,
-0.014855044,
-0.0028034286,
0.0104433065,
0.003058585,
0.0101996735,
-0.021242186,
0.059630886,
0.025048133,
-0.005327008,
0.0023622548,
-0.019596016,
0.06505667,
0.009047354,
0.022374751,
-0.011068852,
-0.026167529,
0.014078052,
-0.01026552,
0.031843524,
-0.03629477,
-0.00461257,
0.023178082,
-0.017344054,
0.03136943,
-0.009784838,
-0.005718797,
0.013261551,
-0.0050142356,
0.01618515,
0.0069402554,
-0.054731883,
-0.00871812,
0.043248195,
0.03089533,
0.0064398195,
-0.020030605,
0.00933708,
-0.007526292,
-0.03313412,
0.0034931742,
-0.00870495,
0.010680355,
0.0023951782,
-0.031079702,
0.024073599,
0.017317716,
0.012254095,
-0.0057352586,
-0.019767217,
-0.019872572,
0.0003000146,
-0.0064134807,
-0.011345408,
-0.005172268,
-0.00985727
] |
Morphogenesis and pattern formation are vital processes in any organism, whether unicellular or multicellular. But in contrast to the developmental biology of plants and animals, the principles of morphogenesis and pattern formation in single cells remain largely unknown. Although all cells develop patterns, they are most obvious in ciliates; hence, we have turned to a classical unicellular model system, the giant ciliate Stentor coeruleus. Here we show that the RNA interference (RNAi) machinery is conserved in Stentor. Using RNAi, we identify the kinase coactivator Mob1--with conserved functions in cell division and | [
-0.020048555,
0.0030378613,
0.017030636,
0.00034441837,
0.011340463,
0.012104914,
-0.018745665,
0.008907515,
-0.014757225,
-0.02627052,
0.0118988445,
-0.00077566836,
0.009598844,
0.016020231,
-0.010123989,
0.022069365,
0.0283711,
-0.0029697255,
0.0020606937,
0.035683237,
-0.023864161,
0.04743584,
0.0036726878,
-0.03557688,
-0.0026174134,
0.015302313,
0.0068036127,
-0.031428903,
0.0060192198,
-0.02333237,
0.0006535224,
0.003988439,
-0.0063216765,
-0.02829133,
-0.007498266,
0.0055140173,
0.027520232,
-0.01485029,
0.007219075,
0.005387717,
0.025539307,
-0.0020473988,
-0.0075315027,
-0.012915896,
-0.021590753,
0.013693642,
-0.022069365,
-0.0019360549,
0.005753324,
0.016751446,
0.014384971,
-0.00036103686,
-0.007664451,
-0.0138132945,
-0.01568786,
-0.0035895954,
0.017309826,
0.0069864164,
0.011493352,
-0.007890463,
0.0008084899,
0.008841041,
-0.00508526,
0.0077442196,
-0.009931214,
0.01249711,
-0.01216474,
-0.0022285404,
-0.009286417,
0.016299423,
0.033263583,
0.031880926,
-0.0057898844,
0.006368208,
0.009439306,
-0.022587862,
-0.026071098,
0.0043341042,
-0.012696532,
0.016990751,
-0.010443063,
-0.014092485,
0.01875896,
0.027121387,
0.012736416,
0.0023465317,
0.010416474,
0.021537572,
0.0030013006,
0.0045401733,
0.019024856,
0.031960692,
0.020899422,
0.019942196,
-0.00650448,
-0.0052514453,
-0.022441618,
0.0322,
0.012663295,
-0.028557226,
-0.014065896,
0.006866763,
-0.0019593209,
-0.017416185,
-0.018466474,
0.010363295,
0.022335261,
-0.0065277456,
0.034380347,
-0.007092775,
-0.022149133,
0.00838237,
0.008641618,
-0.035284393,
0.032598846,
-0.004038295,
0.037331793,
0.023624856,
-0.002589162,
-0.025645666,
0.012397399,
0.010669075,
0.009997688,
-0.035310984,
0.043527167,
0.009067052,
-0.015036416,
0.019184394,
-0.018865319,
-0.0173763,
0.012271099,
0.008502023,
0.007066185,
0.021989595,
-0.009691908,
-0.011367052,
-0.016086705,
-0.01906474,
0.0020324423,
-0.037969943,
0.0052481215,
0.014557804,
-0.028557226,
-0.000013943958,
0.0047362717,
0.014318497,
0.03209364,
0.008794509,
0.011041329,
0.012729769,
0.01035,
-0.009180058,
0.028158382,
-0.015116185,
0.023651445,
0.040416185,
-0.028450867,
0.03089711,
0.0046132947,
0.0084621385,
0.008196243,
0.0016419075,
0.015275722,
-0.014278613,
0.026336994,
0.021005781,
0.015249133,
0.0046365606,
0.003892052,
0.00078563945,
-0.017256647,
0.019024856,
-0.033210404,
0.028025433,
0.0009829841,
-0.0014832009,
-0.0103699425,
0.021577457,
-0.02077977,
-0.008468786,
0.007278902,
-0.0021587429,
0.031774566,
0.009818208,
-0.0062452313,
-0.0030245665,
0.009406069,
0.0024911128,
0.013946243,
-0.018293642,
-0.029833525,
0.013367919,
0.005869653,
0.010150578,
-0.6390012,
-0.016631791,
0.014903468,
-0.027413873,
0.008289306,
0.02668266,
0.007797399,
-0.025818497,
0.007637861,
0.011486705,
-0.01579422,
0.020633526,
0.009831503,
-0.012669942,
-0.045228902,
-0.032146823,
-0.017854914,
-0.022853758,
0.015475145,
0.01753584,
-0.015049711,
-0.008761272,
0.007983526,
0.014890173,
-0.005440896,
0.025113873,
0.03281156,
0.007278902,
-0.0022302023,
0.016618498,
-0.022508092,
0.021564161,
-0.015382081,
-0.011991908,
0.036693644,
0.01132052,
-0.015701156,
0.019317342,
0.0027603323,
0.016990751,
-0.01640578,
-0.0016684971,
0.020274566,
0.005397688,
-0.015023122,
0.003978468,
-0.010974855,
-0.028131792,
-0.012536994,
-0.00084712787,
-0.01972948,
0.020553757,
-0.020487284,
0.007518208,
0.010848555,
-0.022375144,
0.0143317925,
-0.0032455926,
0.0011990246,
0.015382081,
-0.01449133,
0.0038687862,
-0.022441618,
-0.015249133,
0.0056469655,
0.011008092,
-0.02954104,
-0.0028783237,
-0.008136416,
-0.0019975433,
0.013321388,
0.01832023,
-0.0031674856,
0.014119076,
-0.0137069365,
0.05065318,
-0.0026489885,
0.009891329,
-0.017256647,
0.014624277,
-0.012197977,
0.0017183527,
-0.020168208,
-0.0031392341,
0.03871445,
-0.010356648,
-0.014225434,
0.02624393,
0.012118208,
0.01574104,
0.014730636,
0.013268208,
-0.009658671,
-0.038847398,
-0.018227167,
0.039831214,
-0.01998208,
0.00999104,
0.020500578,
-0.04807399,
-0.02238844,
-0.010463006,
0.01017052,
0.0048825145,
0.009937861,
-0.0020274566,
-0.027187862,
-0.001636922,
0.04339422,
-0.04155954,
0.013215029,
-0.0038089596,
-0.029408094,
-0.014863584,
-0.004038295,
-0.027520232,
0.005165029,
0.029142197,
-0.0071725436,
-0.03493873,
-0.009658671,
-0.012696532,
-0.0018994942,
-0.00092066475,
0.02062023,
-0.014571099,
-0.016658382,
-0.021444509,
-0.013301445,
0.007544798,
0.006325,
-0.02141792,
0.022574566,
-0.013986127,
0.03507168,
0.00838237,
-0.0031625,
0.00583974,
0.015448555,
-0.025193641,
-0.011559826,
-0.016312717,
-0.00013035134,
-0.025818497,
-0.0075381505,
-0.017136995,
-0.015568208,
-0.010802023,
-0.020580348,
-0.0054309247,
0.012018497,
-0.0027703035,
-0.021351445,
0.014531214,
-0.0028683527,
-0.006880058,
-0.026110983,
-0.015541619,
0.008282659,
-0.01773526,
0.0077442196,
0.0052514453,
-0.03233295,
0.016831214,
-0.017083814,
0.004387283,
0.0064612716,
-0.001238909,
0.028450867,
-0.031774566,
-0.008016763,
-0.0069731213,
-0.0065609827,
0.006208671,
-0.011167631,
0.011480058,
-0.017668786,
0.008063295,
-0.0077043353,
-0.0050719655,
-0.0053245667,
-0.032944508,
-0.013155202,
-0.024435839,
0.00508526,
0.0007287211,
0.039006937,
0.015820809,
0.026217341,
0.031242775,
0.011765896,
0.019264162,
-0.004197832,
0.0039319363,
-0.0017931359,
-0.030578036,
0.020500578,
0.01681792,
0.0027138006,
0.05147746,
0.01773526,
-0.0031658236,
0.006391474,
-0.01249711,
-0.0010835261,
-0.01234422,
0.0026921965,
-0.031907514,
0.01604682,
0.01331474,
0.021019075,
0.0067171967,
-0.016552024,
-0.012683237,
0.033343352,
0.009904624,
-0.016086705,
-0.0076777455,
-0.017682081,
0.011932081,
-0.009971098,
-0.004048266,
0.008615029,
-0.0064645954,
0.00071625726,
0.020181503,
-0.008934104,
0.015448555,
0.0025974712,
0.015049711,
-0.024063583,
0.02898266,
0.0038322255,
-0.005321243,
-0.000023668375,
0.020301156,
-0.0068933526,
-0.015382081,
0.03291792,
0.0034101156,
0.011619654,
0.017083814,
-0.014012717,
0.00590289,
0.031109827,
0.003725867,
0.051504046,
0.013534104,
-0.011533237,
0.023824278,
0.009758381,
0.019689595,
-0.041107513,
-0.016910983,
0.010077457,
-0.018825434,
0.016578613,
0.016671676,
0.036454335,
0.0137069365,
-0.0050154626,
-0.012277746,
-0.00010729317,
-0.0232526,
0.015302313,
0.01804104,
0.00886763,
-0.012550289,
-0.04209133,
0.010190463,
-0.020633526,
-0.006880058,
0.02599133,
-0.02335896,
0.027028324,
0.005098555,
0.023744509,
0.006421387,
0.00568685,
0.0068933526,
0.009086994,
0.0019127891,
0.01576763,
0.016698265,
-0.0068268785,
-0.03230636,
-0.022042776,
0.0047927746,
-0.005447543,
-0.0100575145,
-0.0076578036,
0.0028932805,
0.008515318,
0.005261416,
-0.025246821,
-0.00420448,
0.0034466763,
-0.027706359,
0.03533757,
0.00050478685,
0.007179191,
0.008402312,
-0.00035023483,
0.0077575147,
0.025938151,
0.0009372833,
-0.0048725433,
-0.01515607,
-0.009399422,
-0.04124046,
-0.03209364,
-0.027440462,
0.022707514,
-0.00557052,
-0.023053179,
-0.009512428,
0.000597435,
0.007465029,
0.035310984,
0.014836994,
-0.016778035,
-0.022933526,
0.011566474,
-0.019436995,
0.04993526,
0.028238151,
0.0059760115,
0.022348555,
-0.013972833,
-0.0032655348,
-0.008628324,
-0.02394393,
0.0037458092,
-0.039724857,
-0.006727168,
0.002298338,
0.0034466763,
-0.015116185,
-0.0014250361,
0.021431213,
-0.017549133,
-0.002698844,
0.003958526,
0.016512139,
0.0126300575,
-0.01579422,
0.015993642,
0.04655838,
0.027972255,
0.00254263,
0.006767052,
0.02765318,
0.0010635838,
-0.004619942,
0.01295578,
0.015581503,
0.01035,
0.003572977,
-0.0075580925,
-0.02624393,
0.009146821,
0.016206358,
-0.0161,
-0.00078771677,
0.020992486,
-0.00047736632,
-0.000829263,
-0.009578902,
0.0055239885,
-0.021564161,
0.008136416,
0.0043341042,
-0.011712717,
-0.013487573,
0.023890752,
-0.036906358,
0.03089711,
-0.025871677,
0.029673988,
0.010735549,
-0.00054259395,
0.010635838,
0.0094326595,
-0.008289306,
-0.007298844,
-0.032598846,
-0.0025575866,
-0.012264451,
0.001857948,
-0.004091474,
0.008435549,
-0.0055539017,
-0.025685549,
-0.0014217125,
0.022587862,
-0.029434683,
-0.03727861,
-0.017509248,
0.018027745,
0.036587283,
0.02369133,
-0.012995665,
-0.004390607,
0.03148208,
0.005228179,
-0.027227746,
-0.008814451,
-0.03150867,
0.00012349621,
-0.002986344,
0.008176301,
-0.018945087,
-0.016552024,
0.00291987,
0.0024046965,
0.008641618,
0.008621677,
-0.009193352,
-0.019277457,
0.01906474,
0.0173763,
0.02970058,
-0.027280925,
-0.011034682,
-0.006391474,
-0.022082658,
-0.006295087,
-0.017402891,
-0.012683237,
-0.019889018,
0.004909104,
0.01781503,
-0.025685549,
-0.005317919,
0.0104763005,
0.00088410405,
0.016578613,
0.022295376,
0.018905202,
0.017269943,
0.0028533959,
0.001514776,
-0.0009647038,
-0.0027786128,
0.0042310692,
-0.005663584,
0.022242196,
0.01035,
-0.03028555,
0.009239884,
-0.006966474,
-0.0020324423,
-0.021923121,
-0.0057067918,
-0.019875722,
0.04278266,
0.01676474,
-0.06051792,
0.0010752168,
0.0021736994,
0.002432948,
0.0059760115,
0.0019709538,
-0.015647978,
-0.008515318,
0.01198526,
0.012098266,
-0.01701734,
0.004038295,
-0.039139885,
-0.0040283236,
0.009439306,
-0.0069,
-0.0021055636,
-0.0057965317,
-0.017522544,
0.00617211,
-0.0152358385,
0.0036693641,
-0.035231214,
-0.023957226,
-0.012443931,
0.032067053,
0.0034533236,
0.023545086,
0.013720231,
0.018532949,
0.033236995,
-0.004443786,
-0.0029049134,
-0.0034200868,
0.014916763,
-0.025845086,
0.02210925,
0.011792486,
0.010409826,
0.014345087,
-0.028450867,
0.008880925,
0.029248554,
-0.02169711,
-0.04219769,
-0.01707052,
-0.018373411,
-0.034460116,
0.006152168,
-0.018825434,
-0.024130058,
-0.0061222543,
-0.025140462,
0.0158474,
-0.01231763,
0.010868497,
-0.026110983,
0.014584393,
-0.012058382,
0.042809248,
-0.013460983,
0.022827167,
-0.020194799,
-0.0115864165,
0.00059203396,
-0.008515318,
0.016312717,
-0.0008496207,
-0.0025725435,
0.033130635,
-0.0068268785,
0.001570448,
-0.007365318,
-0.037863582,
-0.015169364,
-0.009878035,
-0.013733526,
-0.00196763,
-0.008442197,
-0.02596474,
-0.043447398,
-0.004287572,
-0.009492486,
-0.014451445,
0.0052148844,
0.002765318,
-0.024462428,
0.024289595,
-0.013839885,
0.0309237,
-0.019849133,
0.017549133,
0.020234682,
-0.0055572256,
-0.014145665,
-0.01906474,
-0.00010225569,
-0.0074450867,
0.037783816,
0.0038787574,
-0.006258526,
-0.024063583,
0.031428903,
-0.0044836705,
-0.011765896,
-0.03751792,
0.0019543353,
0.018945087,
0.014863584,
-0.008289306,
-0.0049789017,
-0.027280925,
0.009040463,
-0.012603468,
-0.00018186867,
-0.0283711,
-0.00656763,
-0.01413237,
0.0071658962,
-0.006544364,
0.020287862,
-0.0045268787,
-0.007544798,
0.012782948,
-0.00012557353,
0.011433526,
0.024316186,
-0.010217052,
0.012397399,
0.015328902,
0.0061654625,
0.013367919,
0.0141589595,
0.0011342125,
-0.004320809,
-0.01640578,
0.040336415,
-0.019875722,
-0.005088584,
0.012084971,
-0.000779823,
-0.0009256503,
-0.027440462,
-0.008415607,
0.0036294798,
-0.013148555,
0.009818208,
0.010084104,
0.015714452,
0.020713296,
-0.006025867,
-0.02333237,
-0.0001048004,
-0.012091619,
-0.023013296,
-0.00004850524,
-0.034965318,
-0.016312717,
0.017482659,
0.010901734,
0.02000867,
-0.016950868,
-0.016724857,
-0.0017665463,
0.034539886,
0.002886633,
0.023784393,
0.011074566,
-0.009658671,
-0.029408094,
0.015594798,
-0.0072390176,
-0.035736416,
0.026483238,
-0.028610405,
-0.020460693,
0.014039307,
0.0046099713,
0.018253757,
-0.000037755148,
-0.00486922,
0.0033851878,
0.016990751,
-7.676318e-7,
0.0010212066,
-0.0056768786,
0.0033851878,
-0.0067371386,
0.01382659,
0.006052457,
-0.009346243,
0.000058580204,
0.00453685,
-0.0063117053,
0.0022518064,
-0.031349134,
-0.028504046,
-0.02765318,
0.025206937,
-0.01964971,
0.0019493498,
0.022627747,
-0.024449132,
-0.026895376,
0.013720231,
-0.004835983,
-0.009851445,
-0.02230867,
-0.0058231214,
0.03275838,
0.0094326595,
-0.019968787,
0.0053013004,
0.0057034683,
0.0006597543,
-0.03305087,
0.004181214,
-0.027360694,
0.04355376,
0.0012405708,
0.0015330564,
-0.023877457,
-0.011652891,
-0.03499191,
-0.02818497,
0.012510405,
0.0012588511,
0.010895086,
0.0019626445,
0.00822948,
0.012669942,
-0.007418497,
0.0033536127,
0.024369365,
-0.004962283,
-0.006248555,
-0.010097399,
0.0055838153,
0.0038189306,
-0.039006937,
-0.016711561,
0.028105203,
-0.020713296,
-0.013082081,
0.01040318,
-0.025579192,
0.02693526,
-0.014996532,
0.0022734103,
0.012211272,
0.019809248,
0.01684451,
-0.028557226,
-0.026722543,
0.0073387283,
-0.0108219655,
-0.029886706,
0.0033336706,
-0.015541619,
0.019144509,
0.0057998556,
-0.012397399,
-0.026695954,
0.021178612,
-0.0069398843,
0.018413294,
0.00057001447,
0.012217919,
0.011672832,
0.010250289,
-0.008967341,
-0.013321388,
-0.020992486,
-0.031030059,
-0.005716763,
0.018386705,
-0.0012414018,
0.020753179,
0.005836416,
-0.0143317925,
-0.018001156,
-0.00041359285,
-0.0015546604,
0.021444509,
-0.012078323,
0.00105112,
-0.004596676,
-0.00029186235,
0.011041329,
0.01418555,
0.0017432803,
-0.024356069,
0.0077242777,
0.022082658,
-0.015714452,
0.026376879,
-0.0038687862,
-0.016219653,
0.0031126444,
0.009146821,
0.009133526,
-0.025845086,
0.0031442198,
0.17612948,
-0.017083814,
0.008575144,
0.016206358,
-0.0060790465,
-0.026722543,
0.02829133,
0.000104333005,
0.011765896,
0.0015355492,
0.017868208,
-0.0063715316,
-0.008455492,
0.0029680636,
0.029647399,
-0.037677456,
-0.013853179,
-0.010622543,
-0.016272832,
-0.014863584,
0.020593641,
-0.019822543,
0.004191185,
0.019197688,
0.047063585,
0.0031691475,
-0.034300577,
0.0014541185,
0.011539885,
-0.009160115,
-0.021178612,
-0.00871474,
0.0031924134,
-0.01185896,
0.010104046,
0.0055007227,
-0.00468974,
0.026895376,
0.00986474,
0.0017150289,
0.0050254334,
0.010463006,
0.020686705,
-0.01512948,
0.022960115,
0.026762428,
-0.014664162,
-0.012204625,
-0.0025642342,
-0.015089596,
-0.050786126,
0.018213874,
0.018998265,
0.029993065,
0.014012717,
-0.017243354,
-0.00068634393,
0.009565607,
0.0084621385,
0.02895607,
-0.030152602,
0.017230058,
-0.023983816,
-0.010828612,
-0.026549712,
0.023226012,
-0.0030910405,
0.020567052,
0.00049315393,
-0.02890289,
-0.007823989,
-0.023678035,
-0.023053179,
0.013640462,
-0.022268787,
-0.021245087,
0.0075713876,
0.01970289,
0.014903468,
0.013786705,
-0.0026739163,
0.014358382,
-0.045255493,
0.0030777457,
0.015780926,
-0.033077456,
0.028025433,
0.017203469,
-0.019716185,
-0.005517341,
-0.0029298412,
-0.025087284,
-0.012669942,
0.0043407516,
0.034087863,
-0.00557052,
-0.002432948,
0.010090752,
0.008322543,
-0.005175,
-0.02951445,
0.05839075,
0.028849712,
0.016791329,
-0.007996821,
0.009273121,
-0.0076245666,
-0.012749711,
-0.015289018,
-0.027054913,
0.009326301,
-0.013986127,
0.014398266,
-0.0102237,
0.0008496207,
-0.00033818642,
0.018692486,
-0.018665897,
0.04461734,
0.0035995664,
-0.016857803,
-0.022587862,
-0.0030212428,
0.03751792,
-0.017469365,
-0.0017731937,
-0.0055505782,
0.0056702313,
-0.0146109825,
-0.029913295,
-0.0070063584,
-0.00838237,
-0.001990896,
0.01773526,
0.002211922,
-0.0146109825,
0.0022385116,
-0.016259538,
0.0026523122,
-0.0057333815,
-0.018865319,
-0.009479191,
0.0061023124,
0.019862428,
0.007976878,
-0.008136416,
0.02006185,
0.014291908,
0.0018878613,
-0.017136995,
-0.007212428,
-0.025459537,
0.0024512284,
-0.0043706647,
0.010921677,
-0.008103179,
-0.019024856,
-0.021896532,
0.007823989,
-0.0111011565,
-0.037544508,
-0.005563873,
0.032412715,
-0.007578035,
0.0018994942,
-0.01282948,
-0.16730173,
0.0066872835,
0.020819653,
-0.019822543,
0.016392486,
-0.0014649206,
-0.001977601,
0.0013668714,
0.010363295,
0.0049157515,
0.02652312,
-0.011486705,
-0.033210404,
-0.034646243,
0.021178612,
0.016618498,
-0.0013726879,
0.034672834,
0.0018413295,
0.016246242,
0.046478614,
-0.045122545,
-0.004988873,
-0.011991908,
0.00050270953,
0.02072659,
0.015355491,
-0.004929046,
-0.018852023,
-0.027467052,
0.00020378432,
0.013374567,
-0.0043673413,
-0.0070063584,
0.024621965,
0.010934971,
-0.010988151,
-0.0025675579,
-0.0025725435,
0.012204625,
0.023558382,
0.030019654,
0.0046398845,
-0.011839017,
-0.013613873,
0.03289133,
-0.009206647,
0.0091202315,
0.04605318,
-0.020354336,
0.013374567,
-0.013155202,
0.004623266,
-0.00050146313,
0.045601156,
0.008781214,
0.01906474,
0.037225433,
0.01809422,
-0.013334682,
0.016884394,
-0.023545086,
0.037863582,
0.0016128252,
0.006813584,
0.0015205925,
-0.00023348989,
0.022508092,
-0.03685318,
-0.0037125724,
-0.0012580203,
-0.009459249,
0.0031492051,
-0.0288763,
0.019410405,
0.010609249,
-0.0002609104,
0.012590174,
-0.0065410407,
0.0011865607,
-0.023053179,
0.017668786,
0.0058297687,
-0.02721445,
-0.0015463511,
-0.004722977,
0.014026011,
0.006168786,
-0.0138,
0.002963078,
0.02361156,
-0.0126300575,
-0.009246532,
-0.013281503,
0.023558382,
0.027174566,
-0.017083814,
-0.015927168,
0.012550289,
0.0023016618,
0.011792486,
0.013188439,
0.0071725436,
0.031136416,
0.025153758,
0.006491185,
0.009086994,
0.010841908,
0.04945665,
0.0054043354,
-0.011267341,
0.011892197,
-0.0029298412,
0.01546185,
-0.020646822,
0.017589018,
-0.0002096008,
-0.01132052,
-0.01975607,
-0.019676302,
0.06397457,
0.004500289,
-0.010117341,
0.01770867,
-0.008761272,
-0.033290174,
-0.13082081,
-0.029434683,
-0.00080932083,
0.026509827,
-0.020965897,
0.017256647,
-0.013627168,
0.03820925,
-0.013102023,
0.039671678,
-0.011613006,
-0.031907514,
-0.021510983,
-0.00036851518,
-0.018984972,
0.00023078937,
-0.0035763006,
0.001294581,
-0.009665318,
0.021471098,
-0.016166475,
-0.012370809,
-0.0072921966,
-0.008887572,
-0.00007208273,
0.013228324,
-0.026390174,
0.0031392341,
0.025486127,
0.00089656794,
0.004985549,
0.0026556358,
0.008960694,
-0.018838728,
-0.016871098,
-0.0031708092,
-0.007784104,
-0.021019075,
0.029993065,
-0.023744509,
0.0030893786,
0.005447543,
0.017136995,
-0.010070809,
0.009678612,
-0.004423844,
0.0036294798,
0.016552024,
-0.0054575144,
-0.004433815,
-0.020314451,
-0.016658382,
-0.015023122,
-0.028636994,
0.017748555,
-0.035284393,
0.0016294436,
0.009525723,
0.0020374279,
0.0043706647,
0.0124904625,
0.0037557804,
-0.013487573,
0.0030395233,
0.01247052,
-0.017163584,
-0.03089711,
-0.03028555,
0.021683816,
-0.033130635,
0.00868815,
0.009678612,
0.0045800577,
0.00063981215,
-0.007132659,
0.0017715318,
-0.019835839,
-0.009911272,
-0.022321966,
-0.020500578,
-0.0017266618,
-0.02103237,
0.031854335,
-0.029275145,
0.028158382,
0.010296821,
0.012995665,
-0.030604625,
0.009226589,
-0.000004560349,
-0.012204625,
0.035895955,
-0.0052913297,
-0.032652024,
-0.008741329,
0.0034333814,
0.0032190029,
0.005297977,
0.0012330925,
0.0036760117,
-0.023491908,
-0.005407659,
-0.04597341,
0.019875722,
0.006813584,
-0.0068268785,
-0.00535448,
-0.010104046,
0.0068401736,
-0.004354046,
-0.012856069,
0.024675144,
-0.024369365,
-0.0005853866,
0.006138873,
-0.015475145,
-0.028690174,
-0.010276878,
0.041160695,
-0.0014316835,
0.016804624,
0.023465319,
0.0074384394,
0.013946243,
0.032652024,
0.014012717,
-0.013354625,
-0.024236416,
-0.011699422,
-0.015727745,
-0.009658671,
0.0050287573,
0.011772543,
-0.02962081,
0.0028783237,
0.00219198,
-0.008708092,
-0.010070809,
0.01742948,
0.039698265,
0.017190173,
0.045707516,
-0.015727745,
-0.03746474,
-0.005052023,
0.012404046,
-0.017987862,
0.007272254,
-0.026735839,
0.019051446,
0.00950578,
-0.01684451,
0.013480925,
0.005121821,
-0.017469365,
-0.02662948,
-0.03137572,
-0.014119076,
0.0037291907,
-0.0032140173,
-0.008016763,
-0.02698844,
0.029301735,
0.009293064,
-0.004593353,
-0.0076910406,
-0.0042443643,
-0.00550737,
-0.028610405,
0.012304336,
-0.014026011,
-0.034008093,
-0.033157226,
-0.008528613,
0.009166763,
-0.0021720375,
0.0049589598,
0.0018180636,
-0.022295376,
-0.00641474,
0.0007158418,
0.02369133,
0.021683816,
0.016618498,
-0.015488439,
0.009206647,
0.027187862,
0.0010802023,
0.018373411,
0.023824278,
0.011706069,
0.0060325144,
0.00023598266,
0.021564161,
0.0072855493,
-0.005414306,
0.0036028903,
0.017575722,
-0.025432948,
0.026430057,
-0.022175722,
0.009406069,
0.008694798,
0.016179768,
0.012530347,
-0.036959536,
-0.0057699424,
0.012556937,
-0.00838237,
-0.033104047,
-0.009745087,
-0.0009090318,
0.009851445,
0.0047362717,
-0.010489595,
-0.0069398843,
-0.008163006,
0.018546242,
0.003835549,
-0.028796531,
0.0037325146,
0.027812717,
0.011440174,
0.0161,
0.00074575504,
-0.02269422,
0.0013236633,
0.041825432,
0.03749133,
-0.017589018,
0.0288763,
-0.008362428,
0.018360116,
-0.011293931,
-0.0021088873,
-0.0073254337,
-0.011666185,
-0.023239307,
-0.0027703035,
0.011054625,
-0.04732948,
0.08636301,
-0.008315896,
-0.0184,
0.014717341,
-0.026735839,
0.018838728,
0.0114135835,
0.01512948,
-0.019995376,
-0.024621965,
0.022149133,
-0.008143064,
0.011327168,
-0.019928902,
-0.010981503,
0.0039419075,
-0.027108092,
0.03025896,
-0.0076245666,
-0.030046243,
0.01249711,
-0.013680347,
0.009399422,
0.0068534683,
-0.007578035,
-0.012796243,
0.016658382,
-0.00097052025,
0.007298844,
-0.00999104,
0.0023365607,
-0.0060424856,
-0.034539886,
-0.010177168,
0.0001371026,
0.00010023031,
0.0008525289,
0.003985116,
0.0149566475,
0.016060116,
-0.020460693,
0.00444711,
-0.027706359,
-0.02688208,
-0.010762139,
-0.013075434,
-0.0082161855,
-0.0032489162,
-0.019051446
] |
The complex repertoire of immune receptors generated by B and T cells enables recognition of diverse threats to the host organism. In this work, we show that massively parallel DNA sequencing of rearranged immune receptor loci can provide direct detection and tracking of immune diversity and expanded clonal lymphocyte populations in physiological and pathological contexts. DNA was isolated from blood and tissue samples, a series of redundant primers was used to amplify diverse DNA rearrangements, and the resulting mixtures of barcoded amplicons were sequenced using long-read ultra deep sequencing. Individual DNA molecules were then characterized on the basis of DNA segments that had been joined to make a functional | [
-0.038617168,
0.003226513,
-0.015592288,
-0.026216049,
-0.010058237,
0.024640663,
-0.0039754948,
0.0001885078,
-0.046749935,
0.0013304948,
-0.0027266308,
-0.010226548,
0.007890398,
0.0006290606,
-0.010940185,
-0.006166898,
0.029164849,
-0.0076480308,
-0.021220593,
-0.00792406,
-0.04020602,
-0.00030127587,
0.0052310913,
-0.0061366023,
-0.0065876744,
0.0042885523,
0.01710035,
-0.040798474,
-0.0162386,
-0.0027687084,
0.014892116,
-0.003500859,
-0.0184603,
-0.003162555,
-0.016790658,
-0.018217932,
0.018150607,
-0.0053758384,
0.02346922,
-0.008321273,
0.0028124691,
0.009876463,
-0.008651162,
-0.0012522304,
0.008449188,
-0.002671088,
0.01921433,
-0.018191002,
-0.013316729,
0.009479249,
0.031076858,
-0.010967114,
-0.013074363,
0.016278995,
-0.03436228,
-0.018756526,
0.018096749,
0.0130474325,
-0.000014345843,
-0.029649584,
-0.010879593,
-0.013054165,
-0.01368028,
0.0013801464,
0.009782208,
-0.0011596596,
0.006180363,
0.019927967,
0.020304983,
-0.0076951575,
0.035224028,
0.01629246,
-0.008415527,
0.011000777,
0.016844518,
-0.012508839,
-0.0009770426,
-0.0019120077,
-0.0059043337,
0.0045073563,
0.018217932,
-0.027764507,
-0.006284715,
0.014582424,
0.009068572,
0.01876999,
0.008449188,
0.008018314,
0.018702667,
-0.01006497,
0.0055845436,
0.015646147,
0.016656011,
0.01704649,
-0.032908075,
0.015982768,
0.008314541,
0.016817588,
0.00028528637,
-0.032908075,
-0.010812269,
0.0033628445,
-0.0011790153,
-0.0154576395,
-0.0307537,
-0.0070219156,
0.0024034744,
-0.016063558,
0.0028276169,
0.012327064,
-0.012138556,
0.023617335,
-0.016117416,
-0.032988865,
0.03751305,
-0.0021139802,
-0.0035850145,
-0.019147007,
0.0032938372,
0.008604035,
0.013936113,
0.006739154,
0.0017335985,
-0.018500693,
0.034658507,
0.03657051,
-0.009681222,
-0.016252065,
0.00044139437,
-0.0078096087,
0.0028730608,
0.02049349,
0.014447777,
0.026660388,
-0.0068300413,
-0.0027569265,
0.01971253,
-0.002347932,
-0.00055626634,
-0.015147948,
0.006214025,
0.03086142,
-0.021732256,
-0.01454203,
0.026404556,
0.02921871,
0.02999967,
0.004376074,
0.0051200064,
0.012953179,
-0.024425225,
-0.013660083,
0.0035446198,
0.013182081,
0.0096744895,
0.006934394,
0.0047227936,
0.025448553,
-0.04025988,
-0.02049349,
0.009539841,
-0.015444174,
0.0062678843,
0.0059952214,
0.018729595,
0.023428826,
0.0025196087,
0.007681693,
-0.002060121,
0.010832466,
0.0010157541,
0.00873195,
-0.0066280686,
0.0029437512,
-0.026431486,
0.019308584,
0.012185683,
0.0042380593,
-0.016777193,
-0.018379511,
0.0029488006,
0.017787058,
0.039559707,
0.0057090935,
-0.022338174,
0.00923015,
0.011438384,
-0.008361667,
0.0018278525,
-0.022392033,
0.015174878,
-0.0081193,
0.0028898919,
-0.012481909,
-0.6488977,
-0.005833643,
0.024425225,
-0.009654292,
0.0067829145,
0.026067935,
0.001901909,
0.026929686,
-0.0049146675,
0.01879692,
0.009209952,
-0.015982768,
-0.0040024244,
-0.033689037,
-0.031238435,
-0.028006872,
0.005227725,
-0.02174572,
0.032665707,
0.006214025,
-0.0236308,
-0.018244863,
0.012030837,
0.01798903,
-0.0196856,
0.0036624372,
0.0015400414,
-0.00859057,
-0.004524187,
0.028195381,
-0.029568795,
0.011297003,
0.008711753,
-0.0035446198,
0.051893502,
0.008314541,
0.0120106395,
0.02986502,
0.025152326,
0.033581316,
0.0105362395,
-0.0006580942,
0.0048338785,
0.007957722,
-0.012892587,
0.02235164,
0.01217895,
0.019025823,
-0.003115428,
-0.0073383395,
-0.0000186588,
0.0002543593,
-0.010145759,
0.0034234363,
0.021839974,
0.0017824086,
0.010206351,
-0.0052479226,
0.0114855105,
-0.009546573,
-0.008482851,
0.0144208465,
-0.014030366,
-0.032908075,
-0.01343118,
0.00524119,
-0.015982768,
-0.0016528094,
0.015094088,
-0.0025936654,
0.033204302,
0.024748381,
-0.009566771,
-0.016198207,
0.0026946517,
0.028464677,
0.012104894,
-0.0048372447,
0.002541489,
0.016911842,
-0.0061567994,
-0.010435253,
-0.023496151,
0.013283067,
0.0051704994,
-0.003645606,
-0.016063558,
0.032073256,
-0.0007637091,
0.008294343,
0.0011184235,
0.009465785,
-0.010448718,
-0.0541556,
-0.025677456,
0.015269131,
-0.0044063698,
0.008644429,
0.0117480755,
-0.024694521,
-0.027575998,
-0.007392199,
0.015161413,
0.005126739,
0.015538429,
-0.0061467006,
-0.017733198,
0.016965702,
0.03745919,
-0.0038307477,
-0.009580236,
0.0076009035,
-0.008671359,
0.017773593,
0.0027737576,
-0.019254725,
0.013471575,
0.021772651,
-0.005220993,
-0.021772651,
0.019833714,
0.0041438052,
0.012885855,
-0.020008756,
0.018298721,
0.015807725,
0.0012749523,
-0.0069478587,
0.018729595,
-0.02610833,
-0.012811798,
-0.031184576,
0.01031407,
-0.010765142,
0.0059514605,
0.009930322,
0.03535868,
0.005220993,
-0.019308584,
-0.032261763,
-0.010845931,
-0.022432428,
0.012293401,
-0.0017436971,
-0.017773593,
0.008550175,
-0.031130716,
0.0039216354,
0.007331607,
-0.014326593,
0.025017679,
0.01876999,
-0.012199148,
-0.0050291186,
0.010441986,
-0.006274617,
-0.016278995,
-0.021085944,
0.0024001081,
-0.011418187,
-0.00083608256,
-0.003834114,
0.010994044,
-0.00029033568,
-0.0013944528,
0.0059649255,
0.0011823815,
0.023980886,
0.0013675231,
-0.03775542,
0.02232471,
-0.012414585,
-0.023536544,
0.0147709325,
0.011283538,
0.0209109,
-0.02652574,
0.012764671,
-0.0125223035,
-0.0055811773,
-0.0026761375,
-0.017531225,
-0.011303736,
-0.013081095,
0.017921705,
-0.006755985,
0.021597607,
0.0010527824,
0.03150773,
0.027212447,
0.011929851,
0.006836774,
-0.013895717,
0.032261763,
0.012643487,
-0.028168451,
0.015053694,
0.0054397965,
0.0016174642,
0.016077023,
-0.0059548267,
-0.0050089215,
0.002347932,
-0.029595725,
0.0054195994,
-0.029595725,
0.007116169,
-0.024815705,
0.030349756,
-0.016319389,
-0.0070825075,
0.011283538,
0.0027114828,
-0.010118829,
-0.0154711045,
0.033042725,
-0.0016814222,
0.004941597,
0.007991384,
-0.0059009674,
-0.0067223227,
0.011943315,
0.03748612,
-0.022701725,
-0.01929512,
0.008752148,
-0.0029336526,
0.0062880814,
0.0058067134,
0.0074864523,
0.005480191,
0.0130407,
0.0110613685,
0.00900798,
0.011034438,
0.012852193,
0.020076081,
-0.011896188,
0.014488171,
-0.0009013029,
0.0024489183,
0.020035686,
0.008597302,
-0.006355406,
0.019699065,
-0.014649749,
0.008523245,
-0.003450366,
-0.0047194273,
0.009862998,
-0.015780795,
-0.010206351,
-0.025717849,
0.020722393,
0.010792072,
-0.0025919823,
0.012643487,
0.0023226854,
0.046776865,
0.015363386,
0.027737577,
0.009661024,
0.0034537322,
-0.0049988227,
0.010246745,
0.01031407,
0.01843337,
-0.015255667,
-0.0060928413,
0.008826205,
-0.0150133,
-0.0066549988,
0.005773051,
-0.019443233,
-0.007964455,
0.03156159,
0.0059548267,
-0.008442457,
0.013720674,
-0.011290271,
-0.014016901,
-0.023496151,
0.014313128,
0.031049928,
-0.00970142,
-0.014811327,
-0.018446835,
-0.02530044,
0.0033325485,
-0.008772345,
0.024304042,
0.0053489087,
-0.0052681197,
0.0037970857,
-0.016602151,
0.0055037546,
0.04287206,
-0.024748381,
0.01348504,
-0.005301782,
0.014057295,
0.00086848234,
-0.014865186,
-0.010819001,
0.035224028,
0.0036355075,
-0.0054532615,
-0.00060886337,
-0.010071702,
-0.010771874,
0.0059817564,
-0.018837316,
-0.008597302,
-0.028868623,
0.006358772,
-0.000942539,
-0.001525735,
0.018177537,
0.0010957016,
-0.011054636,
-0.021893835,
-0.057360232,
-0.00033178215,
-0.007365269,
0.038186293,
0.017234998,
-0.012051035,
0.012603093,
-0.018042888,
-0.010017843,
-0.018366046,
-0.017558156,
0.024088604,
-0.027374025,
-0.031319223,
0.017867846,
0.02997274,
0.0010502577,
-0.011950048,
0.02224392,
0.0043424116,
-0.023213388,
-0.023980886,
0.010650691,
-0.015067159,
0.010556437,
0.013397519,
0.033069655,
0.01926819,
-0.008004849,
0.0253543,
0.017665874,
0.0011781737,
-0.020224193,
-0.0023445657,
0.014272734,
0.011169087,
0.034550786,
-0.005480191,
-0.015107553,
0.0074393256,
-0.0017159259,
0.010004378,
-0.011586498,
0.014824792,
0.013720674,
0.004217862,
0.01256943,
0.016642546,
0.0025128762,
-0.0019254725,
0.009708151,
-0.0014609355,
-0.017800523,
0.02827617,
-0.0209109,
-0.0184603,
-0.021651467,
-0.0007464572,
0.02530044,
-0.0061870953,
-0.016454037,
-0.009492714,
-0.014717073,
0.0019860642,
-0.0058504744,
0.009546573,
-0.010893058,
-0.023927025,
-0.02530044,
-0.008301076,
0.0009408559,
-0.04723467,
-0.016305925,
-0.012232809,
-0.038132437,
-0.019133542,
-0.0045578494,
0.032100186,
-0.00050030305,
0.011350863,
0.020143405,
0.014165015,
0.0047665546,
-0.014784398,
-0.013188814,
0.0035850145,
-0.046992302,
-0.0034705633,
0.018231397,
0.0150133,
-0.016413644,
0.003352746,
0.025031142,
0.0008760563,
-0.010213084,
0.002125762,
0.026242979,
0.0018648807,
0.047692474,
0.02997274,
0.022015018,
-0.008307808,
-0.01876999,
-0.00920322,
-0.03166931,
-0.01965867,
-0.00016294564,
0.003928368,
-0.022109272,
-0.017881311,
0.0012505472,
-0.011323933,
-0.018083284,
0.014797863,
-0.014919045,
0.007903863,
0.011263341,
0.023994349,
0.015040229,
-0.018339116,
0.0008945705,
0.005113274,
-0.015134484,
-0.002666039,
-0.022405498,
0.029676514,
0.013256137,
-0.0031575055,
0.0112364115,
0.0057259244,
-0.014165015,
0.009937054,
-0.016252065,
0.0069411267,
0.023415362,
0.0064967866,
-0.02388663,
-0.0129599115,
0.0037634235,
0.0047194273,
0.0055677127,
0.002445552,
-0.01265022,
-0.008927191,
0.00945232,
0.008745415,
0.0033763093,
0.011721145,
-0.031211505,
-0.010139027,
0.021530284,
-0.018164072,
0.014582424,
-0.011458581,
-0.0075133825,
-0.01707342,
-0.0058269105,
-0.034820084,
-0.0119231185,
0.0005865622,
-0.008206822,
0.037378404,
0.031292293,
0.025031142,
-0.022957558,
0.012475177,
0.024196323,
-0.0022738753,
-0.014488171,
-0.004551117,
0.009937054,
-0.010879593,
-0.0063352087,
0.014461241,
-0.010381394,
-0.008058708,
-0.016669475,
0.028626256,
0.02344229,
-0.013027235,
-0.013471575,
0.008307808,
-0.036624372,
-0.011189285,
0.006405899,
0.0010140709,
0.021207128,
-0.019079681,
0.007917328,
0.023994349,
0.010677621,
0.018581484,
-0.0042313267,
0.036301214,
-0.0015913761,
0.014111156,
-0.008920458,
0.011727878,
-0.0034234363,
-0.010879593,
-0.021611072,
-0.0041438052,
0.02046656,
0.007856736,
0.004820414,
0.021045549,
-0.011115228,
0.0162386,
0.0073854662,
-0.006648266,
-0.015996233,
-0.005894235,
-0.0084626535,
0.005271486,
-0.007001718,
-0.022540146,
-0.021516819,
-0.0029100892,
-0.004419835,
-0.015147948,
0.02318646,
-0.012636755,
-0.010819001,
0.020870507,
0.014905581,
0.015578823,
-0.037109107,
0.0011436701,
0.013525435,
0.007910595,
-0.028733974,
-0.0023815942,
0.00064799556,
0.0054296977,
0.036516655,
0.026875826,
-0.0065068854,
-0.03161545,
0.011680751,
0.012980108,
-0.011700949,
-0.03255799,
0.00015053274,
-0.015807725,
0.004396271,
-0.016467502,
-0.024304042,
-0.0059851226,
0.003115428,
-0.0265796,
0.027158588,
0.0019591346,
-0.012778136,
-0.027185518,
0.010852663,
-0.01710035,
0.009344601,
-0.0209109,
-0.028922481,
-0.011270073,
-0.021947693,
-0.009378263,
-0.038159363,
0.007621101,
0.021085944,
-0.010125562,
-0.006052447,
0.032908075,
-0.0077288197,
0.015080624,
-0.000004602241,
0.008994515,
0.042656623,
-0.026458416,
0.012986841,
0.00055037544,
-0.008186624,
0.001478608,
0.018298721,
-0.018325651,
0.0031137448,
-0.019887572,
0.016831053,
0.013242673,
0.022472823,
-0.0014525199,
0.004012523,
-0.029703444,
-0.01493251,
-0.046426777,
-0.0056148395,
0.018285256,
-0.024452154,
0.0053758384,
0.015578823,
0.027791435,
0.030322826,
0.022284314,
0.02143603,
-0.0075133825,
0.036435865,
-0.04292592,
0.015161413,
0.008570372,
0.013229208,
-0.034631576,
0.002573468,
-0.015753865,
-0.011721145,
-0.0030884983,
-0.01412462,
-0.01710035,
-0.012966644,
-0.016117416,
0.0022772416,
-0.0011108496,
-0.01715421,
0.008004849,
-0.000048810056,
0.031346153,
0.00095263764,
-0.043006707,
0.007964455,
-0.025704386,
0.0038408465,
0.018554553,
-0.028195381,
0.0075941714,
0.014878651,
-0.018446835,
0.036139637,
0.0079509895,
-0.03654358,
-0.013989972,
-0.008011581,
-0.0064025326,
0.005369106,
-0.020870507,
0.0072238883,
-0.0126973465,
0.0049752593,
0.010441986,
-0.012131823,
-0.014016901,
0.003036322,
0.01965867,
0.023011416,
-0.004682399,
0.0076614954,
-0.008173159,
-0.019093147,
-0.032180972,
-0.0035412537,
-0.02219006,
0.014286198,
0.025004214,
-0.007001718,
-0.031992465,
0.017787058,
-0.048365716,
-0.022055412,
0.027872225,
0.010919987,
0.013161884,
0.04790791,
0.0049920906,
0.0037937195,
0.011519173,
0.033715967,
0.014111156,
-0.050250795,
0.021005156,
-0.0031440407,
0.022392033,
0.024290577,
-0.0290302,
-0.011074834,
0.012441515,
-0.0116605535,
-0.013518702,
0.016332854,
-0.020251123,
0.029541865,
-0.009405193,
0.013323462,
-0.0231326,
0.010071702,
0.013175349,
-0.004234693,
-0.00923015,
-0.0025802006,
-0.014878651,
-0.020560814,
0.004365975,
0.0032399779,
0.02171879,
0.020587744,
-0.03403912,
-0.02997274,
0.006745886,
-0.022109272,
0.013397519,
0.018702667,
-0.001717609,
0.013612956,
-0.0066415337,
-0.0007056419,
-0.0014794496,
-0.034658507,
-0.008664627,
-0.0002682449,
-0.0036927331,
-0.0036725358,
-0.0065405476,
0.006277983,
0.0052849506,
-0.013013771,
0.021260986,
-0.006695393,
-0.016440572,
-0.03444307,
0.009600433,
0.017867846,
-0.0060255174,
-0.012192415,
-0.0009265495,
-0.02532737,
-0.025004214,
-0.0051200064,
-0.006890633,
-0.012226077,
0.021570679,
0.01343118,
-0.010280407,
-0.018191002,
-0.013518702,
-0.018069819,
-0.024128998,
-0.014690143,
0.18053661,
-0.029757302,
-0.010031308,
0.021355242,
-0.00038732463,
-0.010280407,
-0.009344601,
-0.00070900813,
-0.008644429,
-0.0027905887,
0.028949412,
-0.014703608,
-0.011000777,
-0.0063486733,
0.017719733,
-0.003948565,
-0.033258162,
-0.00460161,
-0.0012640121,
-0.01153937,
0.0077894116,
-0.002157741,
0.0003378834,
-0.014393917,
0.03694753,
0.013828393,
-0.013128222,
0.0098495325,
-0.008880064,
0.012185683,
-0.024142463,
0.005433064,
-0.0028848425,
-0.0061096726,
-0.0016746898,
0.018204467,
-0.0071229017,
-0.007816341,
0.005752854,
0.0023210023,
-0.009667757,
-0.0004801058,
0.015322991,
-0.01579426,
0.012071231,
0.012374191,
0.0003467197,
-0.012535769,
-0.022674795,
-0.012232809,
-0.019012358,
0.009883194,
-0.03185782,
0.017302323,
0.0039855936,
-0.008765613,
0.03934427,
-0.0016073656,
0.004140439,
0.02519272,
-0.02015687,
0.0054902895,
-0.034227632,
0.029622653,
-0.007446058,
0.029353358,
-0.0015652879,
0.008274145,
0.026337232,
-0.032908075,
0.008873331,
0.0011285221,
-0.00034756126,
-0.011047903,
-0.01749083,
-0.009634095,
0.025408158,
0.008072173,
0.02318646,
-0.009169558,
0.017261928,
-0.00472616,
-0.037028316,
0.013363857,
-0.004631906,
-0.019335514,
0.045888186,
-0.0011184235,
-0.041471716,
0.00850978,
-0.0049483296,
-0.018783456,
-0.014663214,
-0.0054599936,
0.0028511805,
0.008516513,
0.0010123879,
0.011128693,
-0.007095972,
-0.019968363,
-0.014407381,
0.06829368,
-0.006234222,
0.009836067,
-0.025017679,
0.0033948235,
0.009506179,
0.015309527,
0.014097691,
-0.012374191,
0.022284314,
-0.04817721,
0.02143603,
-0.010280407,
-0.0066583646,
0.03762077,
-0.0061366023,
-0.022971021,
0.0342007,
0.013175349,
-0.0014626186,
-0.022149667,
0.0025280241,
0.027454814,
0.0066078715,
0.005537417,
-0.030161249,
0.009176291,
0.019537486,
-0.011970245,
-0.008577105,
0.00731141,
0.0243579,
0.019833714,
-0.0034873942,
-0.017356182,
0.0033258162,
-0.018985428,
-0.03185782,
-0.0066583646,
0.0031558226,
-0.013532167,
0.012858924,
0.0044871587,
0.009209952,
-0.026041007,
0.025435088,
0.022499753,
-0.004951696,
0.005258021,
-0.00022742961,
-0.009075304,
-0.023172995,
0.0058807703,
0.010246745,
-0.019779854,
-0.018204467,
-0.031373084,
0.0053489087,
0.0008836303,
-0.020412702,
0.006038982,
0.010031308,
0.003307302,
-0.010805536,
0.009209952,
-0.17019561,
0.021355242,
0.02527351,
-0.03441614,
0.025825568,
0.017342718,
0.015592288,
0.009438855,
-0.01940284,
0.020708928,
0.044945646,
0.010509309,
-0.022041949,
-0.030619053,
-0.012212613,
-0.013814929,
-0.026444951,
0.040798474,
0.015080624,
0.00018640392,
0.014488171,
-0.021355242,
0.0142458035,
-0.01626553,
0.031346153,
0.00018387925,
-0.004409736,
-0.0006610396,
0.0038745084,
-0.020560814,
-0.016507898,
-0.0019524022,
0.030403614,
-0.026633458,
0.0063520395,
0.01767934,
0.012690614,
-0.0119971745,
0.0031305759,
0.006069278,
0.040071372,
0.028949412,
0.01890464,
0.0072777476,
-0.017342718,
0.027549068,
0.0036489724,
-0.01712728,
0.02221699,
-0.0072777476,
0.016507898,
-0.016723335,
0.021732256,
0.0074864523,
0.030484404,
-0.0069545913,
0.005736023,
0.006439561,
-0.0048439773,
-0.014003436,
0.0070892395,
-0.0067963796,
0.017692802,
-0.009115699,
-0.02185344,
-0.016575221,
-0.015713472,
0.016884914,
-0.011896188,
0.002571785,
-0.016171277,
-0.0010645641,
0.010650691,
-0.0043222145,
0.020008756,
0.03261185,
-0.009600433,
-0.0076614954,
0.020358842,
-0.02235164,
-0.0064159976,
0.013774534,
-0.00964756,
-0.0041370727,
0.0023512982,
0.011640357,
-0.003497493,
0.011034438,
-0.0077557494,
0.009990914,
0.036301214,
-0.03875182,
0.0012000541,
-0.020506956,
0.0072440854,
0.019941432,
-0.00035261057,
-0.018756526,
0.00033998728,
-0.0035210564,
0.0054902895,
-0.019793319,
-0.0043188483,
0.011371059,
0.009883194,
-0.008859866,
-0.0058235447,
-0.010475648,
0.044272404,
0.0044030035,
-0.021422565,
-0.0051805982,
-0.0094994465,
0.0248561,
-0.012744473,
0.025367763,
-0.00079695036,
0.0056787976,
0.009957251,
-0.030268967,
0.07060964,
0.0070219156,
-0.01073148,
0.030672912,
-0.0060322494,
-0.0068165767,
-0.15037537,
-0.0028040535,
0.003241661,
0.0008516513,
-0.017140744,
0.02833003,
-0.014299663,
0.012993573,
-0.026821967,
0.028922481,
-0.012084696,
-0.012744473,
-0.019120077,
-0.021085944,
-0.018971963,
0.01006497,
-0.017773593,
-0.009257079,
-0.018621877,
0.027899154,
0.0017041442,
-0.012535769,
0.019618277,
-0.014191944,
0.0124482475,
-0.0033746262,
-0.026835432,
0.021207128,
0.010475648,
0.016844518,
-0.009910124,
-0.0020517055,
0.0012067865,
-0.030268967,
-0.02307874,
0.0131349545,
-0.027320165,
-0.013525435,
0.021866905,
0.01153937,
-0.014272734,
0.0019658671,
-0.01178847,
-0.0011201065,
0.003850945,
-0.009923589,
0.0010830783,
0.0006601981,
0.0061904616,
-0.024142463,
-0.031777028,
-0.02346922,
-0.036112707,
-0.006920929,
0.0039317342,
-0.00041656857,
-0.0015762282,
0.006860337,
-0.017288858,
0.000982092,
0.009438855,
-0.0034739294,
-0.015605752,
0.006554012,
0.016413644,
-0.0084626535,
-0.00024804764,
-0.008832937,
0.03605885,
-0.0039855936,
-0.0035378875,
-0.007991384,
-0.022890233,
-0.0145958895,
-0.0068670698,
0.011882723,
-0.02109941,
-0.013007038,
0.019927967,
-0.01548457,
0.0019658671,
-0.014097691,
0.005002189,
-0.012441515,
0.023859702,
0.0050122878,
-0.012475177,
0.0043693413,
-0.012778136,
-0.012717544,
-0.02057428,
0.033958334,
-0.014461241,
-0.0005651026,
-0.016817588,
0.011586498,
-0.014717073,
-0.015349921,
0.00834147,
0.044810995,
-0.016252065,
0.010879593,
-0.051489558,
0.022068877,
-0.032100186,
-0.0071229017,
0.020897437,
-0.02699701,
-0.00025898783,
-0.025542807,
0.024681056,
0.012603093,
-0.024721451,
0.015053694,
-0.008529978,
0.010691085,
-0.017719733,
-0.032100186,
0.021638002,
-0.0074864523,
0.0071969586,
0.043006707,
0.004524187,
-0.0050594145,
0.030888349,
0.004328947,
0.007351804,
-0.0012160436,
-0.034523856,
0.03495473,
-0.020076081,
-0.016857984,
-0.0059514605,
-0.022890233,
-0.028787835,
0.0016553341,
-0.013814929,
-0.003021174,
0.003384725,
0.0050392174,
0.029730372,
0.013936113,
-0.018985428,
-0.038267083,
0.0041067773,
0.0058504744,
-0.02052042,
-0.007526847,
-0.028464677,
0.0021863538,
0.006429462,
-0.019927967,
0.047477037,
0.01595584,
-0.00061601656,
-0.04637292,
-0.022849837,
0.0103611965,
0.012508839,
0.002235164,
0.010320802,
-0.026808502,
0.022836374,
0.0150133,
0.01582119,
0.010744944,
-0.0040024244,
-0.020399237,
-0.024169393,
0.007876933,
-0.00088867964,
-0.0082135545,
-0.009479249,
0.023065276,
-0.006934394,
0.0023849602,
0.013397519,
-0.03261185,
-0.008806007,
0.008630964,
-0.02171879,
0.012017372,
0.024519479,
0.015646147,
0.0025297073,
0.0024539677,
0.053590074,
-0.0021341776,
0.0009408559,
0.017558156,
0.0019759657,
0.010139027,
-0.0048473435,
0.011431651,
0.014555495,
0.0152960615,
-0.0065270825,
0.031211505,
0.015349921,
0.019470163,
0.026229514,
0.024452154,
0.0095937,
-0.003958664,
0.029730372,
-0.026754642,
-0.0013136637,
0.02216313,
-0.0063520395,
-0.016857984,
-0.01537685,
0.009539841,
0.0030952308,
0.012576163,
-0.0073046773,
0.0005045108,
-0.026377628,
0.01754469,
-0.0052647535,
0.013572562,
-0.035493325,
0.02407514,
0.028976342,
0.0133099975,
-0.01715421,
-0.0031103787,
0.014138085,
0.0044938913,
0.006880535,
0.009176291,
0.018352581,
-0.007412396,
0.010866128,
-0.0036691697,
-0.016400179,
-0.005682164,
-0.012865657,
-0.009135895,
0.012286669,
0.01965867,
-0.041498646,
0.06775509,
0.0062712505,
-0.01973946,
0.0059514605,
-0.042414255,
0.017638944,
0.015592288,
0.0107112825,
-0.013781266,
-0.01712728,
0.027185518,
-0.0024169392,
0.01749083,
-0.033177372,
-0.018716132,
0.030565193,
-0.023226853,
-0.015255667,
-0.007910595,
-0.009809138,
0.0094994465,
-0.033850614,
0.016979167,
0.0030380052,
-0.02344229,
-0.010919987,
0.00706231,
0.0018345849,
-0.021638002,
-0.015363386,
0.033150442,
-0.021530284,
-0.046588358,
0.007291212,
-0.0019069584,
-0.0074864523,
-0.013195546,
-0.016050093,
-0.0106237605,
0.012441515,
0.008354935,
0.02138217,
-0.030268967,
-0.033312023,
0.015174878,
-0.011108495,
-0.02441176,
-0.018137144,
0.01281853
] |
OBJECTIVE Limited information is available about the metabolic syndrome in Asians. Furthermore, the definition of central obesity using waist circumference may not be appropriate for Asians. The objectives of this study were to determine the optimal waist circumference for diagnosing central obesity in Asians and to estimate the prevalence of the metabolic syndrome in an Asian population. RESEARCH DESIGN AND METHODS We used data from the 1998 Singapore National Health Survey, a cross-sectional survey involving 4,723 men and women of Chinese, Malay, and Asian-Indian ethnicity aged 18-69 years. Receiver operating characteristic analysis suggested that waist circumference >80 cm in women and >90 cm in | [
-0.006553739,
-0.0027986146,
0.03166376,
-0.03781181,
-0.017784478,
0.0019014748,
-0.02211186,
0.0038656173,
-0.008219385,
-0.014736841,
0.0037303867,
0.021729255,
0.008008293,
0.015290958,
-0.019723885,
0.026254535,
0.037706263,
-0.012414833,
0.0019410545,
-0.011069123,
-0.02509353,
-0.005142063,
-0.016794987,
0.004449418,
-0.01758658,
0.01942044,
0.032138716,
-0.020409932,
-0.0049474626,
-0.040001884,
0.018734392,
-0.0023731329,
-0.02386656,
-0.004897988,
-0.0057390565,
0.0060886773,
0.009294633,
-0.017203977,
0.010013664,
-0.04599161,
0.008654761,
-0.009070348,
-0.005653301,
0.0061348537,
0.0033939593,
0.009802572,
0.011741978,
-0.021795223,
-0.0021323564,
0.026228148,
-0.00043290298,
0.027653018,
-0.035357866,
0.01279084,
-0.018299015,
0.010798662,
-0.021795223,
0.015251378,
-0.016992886,
-0.041769776,
0.010561183,
0.00058297603,
-0.022151439,
0.0049375677,
-0.013905669,
-0.017890025,
-0.0011107053,
0.024737313,
0.0047561605,
0.024697734,
0.039738018,
0.04256137,
-0.009736606,
0.0053003817,
0.03084578,
-0.00616124,
-0.014037601,
-0.011676012,
-0.008601989,
-0.0012624275,
0.0325609,
-0.015581209,
-0.0140112145,
0.022903454,
0.01448617,
0.01370777,
-0.024051264,
0.011102106,
-0.002899213,
-0.008133628,
-0.011788154,
-0.01982943,
0.018589266,
-0.00464072,
-0.03279838,
0.0054488056,
0.00029622932,
0.009815766,
-0.004653913,
-0.00840409,
-0.006702163,
0.010515007,
-0.026241342,
-0.019776657,
-0.0019080715,
0.008014889,
-0.00085838477,
-0.031954013,
0.023800593,
-0.0035456815,
-0.009881732,
0.044197332,
0.008067662,
-0.008945012,
0.013173443,
-0.022652782,
0.0045615607,
0.0038887055,
-0.0019591951,
-0.021795223,
0.009598077,
0.029763935,
0.02603025,
0.01232248,
0.011082316,
-0.0044889976,
-0.048946895,
-0.00928144,
-0.02232295,
-0.018773971,
0.01138576,
-0.008747114,
0.035384253,
0.027441926,
-0.017758092,
0.016913725,
-0.005719267,
0.005679687,
-0.013562644,
-0.032903925,
0.01795599,
0.031347122,
-0.0136418035,
-0.011049333,
-0.003271922,
0.025146304,
0.03757433,
0.029895868,
-0.013226217,
-0.008977995,
-0.0028052113,
-0.008437073,
0.03472459,
0.019697499,
0.025449747,
0.01497432,
-0.00040445506,
0.019565566,
-0.015647175,
-0.032217875,
-0.0061876266,
-0.0013811666,
-0.017349102,
-0.00699901,
-0.016887339,
-0.001123074,
0.01362861,
0.00079777837,
-0.0010026857,
0.0029223012,
-0.00044527164,
0.014723648,
-0.0140112145,
0.004244923,
0.01407718,
0.0021966733,
-0.0001601741,
0.00042342034,
-0.020330774,
-0.023536729,
-0.036255006,
0.03219149,
0.012777647,
0.017045658,
-0.012197144,
0.018048344,
0.023365216,
-0.004512086,
0.019961363,
-0.036650803,
0.0047528623,
0.03269283,
0.010561183,
-0.00746737,
-0.6383414,
-0.014631296,
-0.014829194,
-0.011306602,
0.009419968,
0.015093059,
0.012968949,
0.026940582,
0.0044626114,
0.026162183,
-0.015633982,
0.015633982,
-0.0038656173,
-0.020225227,
-0.020159261,
-0.020132875,
-0.021518163,
0.00089549075,
0.016491542,
-0.027098902,
-0.024433868,
0.036255006,
-0.013285587,
0.0131404605,
0.0006984168,
-0.012619328,
0.024183197,
-0.019750271,
0.0032059557,
0.026571173,
-0.011550676,
0.0395797,
0.0045318757,
0.013443905,
0.041848935,
-0.03781181,
-0.016029779,
0.01982943,
-0.004096499,
0.01762616,
-0.024143618,
-0.0097563965,
0.016108938,
-0.0063063656,
-0.018642038,
0.021729255,
0.0016953305,
-0.0042878008,
0.019130189,
-0.016491542,
0.0056434055,
0.0053069782,
0.0014619752,
-0.00028880814,
0.021439005,
-0.03525232,
0.0046143336,
-0.024486642,
0.007632286,
0.025937898,
-0.0011107053,
0.029447297,
0.002833247,
-0.027547471,
-0.021161947,
0.049421854,
-0.014314658,
-0.001673067,
-0.011656222,
-0.013681383,
-0.0040833056,
0.02137304,
-0.020436319,
0.009505725,
0.030793007,
0.0263205,
0.029763935,
0.023734627,
-0.014961127,
-0.01109551,
0.016768599,
0.010693116,
-0.00064110867,
-0.017441455,
-0.017982377,
-0.015779108,
-0.0031531828,
-0.013971634,
0.0017777883,
0.007388211,
0.022138245,
-0.011227442,
0.0012698488,
-0.008562408,
-0.00058751117,
0.018259436,
-0.020212034,
0.0017579984,
0.027468313,
0.0070451866,
-0.025753193,
-0.01856288,
-0.0053201714,
-0.023958912,
0.0033807661,
0.015475663,
-0.029077888,
0.0027244028,
0.05018706,
-0.036017526,
0.025265042,
-0.01811431,
-0.0011857419,
-0.0012723225,
0.0016681195,
-0.020541865,
-0.0011725486,
0.0068077086,
-0.002544645,
-0.003816143,
0.009347406,
-0.004162465,
0.033880223,
-0.009050558,
-0.016491542,
0.028207133,
-0.012652311,
-0.009888329,
-0.0023352024,
-0.029262591,
-0.013852895,
-0.012434622,
0.01635961,
-0.016900532,
0.022494463,
-0.005570843,
0.014710455,
-0.0055642463,
-0.03659803,
-0.049949583,
-0.029763935,
-0.024381096,
0.011656222,
-0.022045894,
0.010468831,
-0.0068604816,
0.013054704,
0.00265184,
0.01571314,
-0.0017497526,
-0.023708241,
-0.029025113,
-0.0068406914,
-0.009485935,
0.014829194,
-0.0076916553,
0.019394053,
-0.025344202,
-0.010897611,
-0.002556189,
-0.0007705673,
0.0035753662,
-0.027441926,
-0.020251613,
0.0051816422,
-0.01942044,
0.018470528,
0.0029503368,
-0.025357395,
-0.01411676,
-0.01709843,
-0.009650851,
-0.005241012,
0.0009911417,
-0.027521085,
0.013081091,
-0.009664044,
-0.0380229,
-0.034170475,
-0.0090043815,
0.02178203,
0.014895161,
-0.04907883,
-0.001977336,
0.053485367,
-0.00090950856,
0.0005433963,
-0.02517269,
-0.008232578,
0.014182726,
-0.034935683,
0.01848372,
-0.014604909,
0.019816237,
0.010435848,
-0.008437073,
0.005099185,
-0.006900061,
0.015304151,
0.015277765,
0.03337888,
-0.012203741,
0.037521556,
-0.00023562291,
0.019288508,
-0.008463459,
0.015620789,
0.018087924,
-0.006715356,
0.017230364,
0.01009942,
0.00034364252,
0.019921783,
-0.0024753804,
0.002394572,
0.016940111,
0.030529143,
-0.016082551,
-0.0050760964,
0.017375488,
0.0013737455,
-0.025040757,
0.014578523,
0.00836451,
-0.006065589,
0.016860953,
0.0086943405,
0.037284076,
-0.0023286056,
-0.014578523,
-0.015594402,
-0.013892475,
-0.002214814,
0.022283372,
0.0068209018,
0.010488621,
0.014538944,
-0.010759082,
0.016557507,
0.021148754,
0.020146068,
0.0011255477,
0.028945955,
-0.028339066,
0.005936955,
-0.015911039,
0.056519814,
0.02659756,
-0.0075993026,
0.0027639824,
-0.00028179924,
0.011583659,
-0.020462705,
0.015198605,
0.022586815,
-0.0065339487,
-0.010145596,
-0.00243745,
0.0076652686,
0.03137351,
0.019882202,
-0.002374782,
-0.018246243,
0.0099345045,
0.018787164,
0.014842388,
0.033563588,
-0.0077312347,
-0.0003207605,
0.007282665,
-0.015106252,
-0.016834566,
0.0012756208,
-0.02778495,
0.010237949,
0.0035225933,
0.010864628,
-0.012197144,
0.036070302,
0.028523771,
0.0017349102,
-0.023127738,
0.008258964,
0.008674551,
0.0027342977,
-0.015779108,
-0.0018355086,
0.011273618,
-0.012058616,
0.024328323,
0.0043042926,
0.01095698,
-0.009730009,
-0.016544314,
-0.03443434,
0.011491306,
0.030291663,
-0.016108938,
0.02725722,
0.01329878,
0.020264806,
-0.0007309876,
0.0006703812,
-0.02741554,
0.012190548,
0.015858267,
0.0006007044,
-0.008094049,
0.009822362,
-0.01062715,
-0.0098751355,
-0.043801535,
-0.011959666,
0.034909297,
-0.0085162325,
0.009947699,
-0.014024408,
-0.0024407483,
0.021043207,
-0.014367431,
0.0042845025,
-0.015765915,
-0.03614946,
-0.009551901,
0.053881165,
-0.010838241,
0.017045658,
0.00049886917,
0.0064448947,
0.0111153,
0.006834095,
-0.023074966,
0.023668662,
0.031056872,
-0.016926918,
-0.0011453376,
-0.001090091,
-0.011049333,
-0.0007437685,
0.0014207463,
-0.005112378,
-0.039157517,
-0.012942562,
0.013826509,
-0.023074966,
0.0026963672,
0.02178203,
0.045120858,
0.017111624,
-0.007843377,
0.0038392309,
0.029447297,
-0.002597418,
-0.038603403,
-0.00969043,
0.02191396,
-0.012348867,
0.030212505,
-0.008569005,
0.03084578,
0.0066295997,
-0.010580974,
0.010086227,
-0.0011238985,
0.022349337,
0.024856051,
0.022415305,
0.018998256,
-0.008839467,
-0.013410922,
0.0060919756,
0.03435518,
0.0060161147,
-0.009169297,
0.016570702,
-0.010811855,
-0.011748575,
-0.02897234,
0.003499505,
-0.00842388,
-0.015462469,
-0.020568252,
0.0007528389,
-0.019816237,
0.0008740517,
0.0015939075,
0.016676247,
0.017969184,
-0.019407246,
0.007177119,
-0.020726569,
-0.00875371,
-0.01868162,
0.01762616,
-0.007157329,
-0.020185648,
-0.0043537673,
0.009835555,
-0.0006580125,
0.0001841899,
0.029763935,
-0.020884888,
0.005775338,
0.014420204,
-0.028391838,
-0.0015741177,
-0.012019035,
-0.01684776,
-0.002181831,
0.020858502,
0.003733685,
-0.024829665,
-0.0112340385,
0.005999623,
0.0028431418,
-0.013602224,
0.019143382,
0.014657683,
0.0072035054,
-0.011577062,
-0.0012294444,
0.00417236,
-0.0044230316,
-0.018668426,
-0.009235264,
-0.0049144793,
0.0009177543,
-0.015132639,
0.001353131,
-0.011577062,
-0.017058851,
-0.023352023,
0.002930547,
-0.02158413,
-0.00013883816,
-0.008291948,
0.005036517,
-0.011550676,
0.027521085,
0.015145832,
0.009947699,
0.038946424,
0.022428498,
-0.008991188,
-0.019064223,
0.011926684,
0.0059303585,
0.0091363145,
-0.026953775,
0.038788106,
-0.01639919,
-0.0038887055,
-0.021887574,
-0.020212034,
0.013463695,
0.030581916,
0.0017151204,
-0.026109409,
-0.007942326,
0.005722565,
0.017850446,
0.007539933,
0.003337888,
0.0015996796,
-0.011695801,
-0.0029453894,
-0.00018120081,
-0.023576308,
0.024433868,
-0.03324695,
0.009499128,
-0.0065735285,
-0.03179569,
0.005600528,
-0.0032587287,
0.0220327,
-0.013166847,
-0.008595392,
-0.015647175,
-0.028708477,
-0.021808416,
-0.024697734,
0.03438157,
0.009208877,
0.019525986,
0.0058017243,
0.029025113,
0.013536258,
0.0053069782,
0.0058643925,
-0.021161947,
0.0079951,
-0.0046671066,
0.014684069,
0.011801347,
-0.00220327,
-0.012500589,
-0.009598077,
0.012223531,
0.02700655,
0.0014512556,
0.007816991,
-0.0034797154,
-0.030001413,
-0.007051783,
-0.005956745,
0.0014298167,
0.0059534465,
-0.041690618,
-0.0150139,
0.015924232,
0.011583659,
0.01848372,
-0.014552137,
0.019130189,
-0.04390708,
0.022296565,
-0.008173208,
0.00376337,
0.006514159,
-0.03419686,
0.0024836261,
0.011656222,
0.019618338,
0.0025215568,
-0.0063888235,
0.009156104,
-0.018430946,
0.022125052,
0.017678933,
-0.020937663,
0.005867691,
0.009413372,
-0.019037835,
0.010026857,
0.0012764453,
-0.010765678,
-0.03398577,
-0.0007594355,
0.011517693,
-0.022560429,
0.020555058,
-0.019116996,
0.0050299205,
0.028840408,
-0.00012482036,
0.01893229,
0.0019591951,
0.053274278,
0.0057258634,
-0.0037897564,
-0.022679169,
0.012434622,
0.0012747962,
0.0019591951,
0.01713801,
0.0071705226,
-0.014209112,
0.017454648,
-0.0008484898,
0.015066673,
-0.03287754,
-0.019763464,
0.012104792,
-0.0047429674,
0.00057143194,
-0.0019855816,
0.0103039155,
-0.037785422,
0.03672996,
-0.029684776,
-0.019446826,
-0.0038788107,
-0.012071809,
0.018246243,
0.038708948,
-0.024697734,
0.010726099,
-0.00013358149,
0.0063591385,
-0.0065933187,
-0.033273336,
-0.024473447,
0.0022296566,
0.021636903,
0.015185412,
-0.0001687291,
-0.0016227678,
0.0012624275,
0.028629316,
-0.003336239,
-0.009888329,
-0.031927627,
0.030872166,
0.011623239,
-0.0128304195,
0.006223908,
-0.018708006,
0.022745134,
0.02513311,
0.0020597936,
-0.0501079,
-0.013490082,
0.017678933,
0.021267492,
0.011280214,
-0.012249918,
-0.010534797,
-0.026993357,
-0.008503039,
-0.013206427,
-0.025924703,
-0.01275126,
-0.013001932,
-0.011682608,
-0.011141686,
-0.028418224,
0.041585073,
0.003026198,
-0.0043405737,
-0.0021785328,
0.0033098524,
-0.031769305,
0.03300947,
0.0005730811,
0.020251613,
-0.027811337,
0.028180746,
-0.009156104,
-0.032666445,
0.024526222,
0.014222306,
-0.024183197,
-0.034988455,
0.014169533,
-0.014103566,
0.0049903407,
-0.01054799,
-0.0045978418,
0.0185233,
0.0010348442,
-0.03369552,
-0.031399895,
0.015647175,
-0.019156575,
0.009228667,
0.022402111,
-0.0023995193,
0.021452198,
-0.014921547,
0.019565566,
0.0030525844,
-0.02068699,
-0.0046341233,
-0.039790794,
0.04593884,
-0.02928898,
0.0029008621,
-0.019934976,
0.0037831597,
-0.010092824,
0.010086227,
0.014961127,
-0.0011288461,
-0.024433868,
-0.008463459,
0.0025792771,
-0.0012690241,
-0.026017057,
-0.011636432,
0.001298709,
0.02390614,
-0.038049284,
-0.0036875089,
-0.029025113,
0.02390614,
0.029975027,
-0.015752722,
-0.028576544,
0.0075135464,
-0.043986242,
-0.0150139,
-0.0036710172,
0.039157517,
-0.014657683,
0.03696744,
0.01815389,
0.0045714555,
0.012942562,
0.010277529,
-0.038339537,
-0.014816001,
0.0112340385,
-0.0255421,
0.018021958,
0.0018684918,
-0.013081091,
0.005894077,
0.027362766,
0.0067252507,
-0.019710692,
0.023681855,
0.024539415,
0.003733685,
-0.019288508,
0.014288272,
0.02068699,
-0.048867736,
0.010336898,
-0.03219149,
0.020106489,
0.013615417,
-0.011847524,
0.013186637,
-0.038286764,
0.0015493804,
-0.00352919,
0.01994817,
-0.007130943,
-0.028259907,
0.0034929086,
-0.006299769,
0.0073420345,
0.0018552985,
0.013720963,
0.011187862,
0.011590255,
-0.013905669,
-0.02799604,
0.0010661782,
-0.00793573,
0.015040286,
0.0045054895,
-0.0007235664,
-0.012216934,
-0.014235499,
0.0300278,
-0.019525986,
0.0027425434,
-0.026254535,
-0.008153418,
-0.03279838,
0.02688781,
0.024433868,
-0.010594167,
-0.015317344,
0.039263062,
-0.035437025,
0.0055774394,
-0.0011181266,
0.0058479006,
-0.024829665,
-0.01493474,
-0.015726333,
-0.0008649814,
0.015159026,
-0.025344202,
-0.036782734,
-0.024697734,
-0.002942091,
0.18407199,
-0.010402865,
0.009063751,
0.019737078,
-0.014459784,
0.02219102,
0.03179569,
0.034487113,
-0.005960043,
0.031267963,
-0.0024588888,
-0.01366819,
0.009103331,
0.016517928,
0.010462234,
-0.021386232,
-0.04316826,
-0.008595392,
0.01062715,
-0.0073948074,
-0.0007136715,
-0.030661074,
0.0004254818,
-0.018008763,
0.026135795,
-0.0056631956,
-0.0004576403,
0.0008068487,
0.02064741,
0.027916882,
-0.018219855,
0.00976959,
0.0072496817,
0.022943033,
-0.02823352,
0.01019837,
-0.005290487,
-0.0011964614,
0.02023842,
-0.0019971258,
-0.007948923,
-0.018193468,
-0.0008484898,
0.0007676813,
-0.01942044,
0.002973425,
-0.008588795,
-0.017863639,
-0.02603025,
0.0069132545,
0.0064679827,
-0.014209112,
0.02211186,
0.022731941,
0.0062634875,
-0.0075465296,
0.025291428,
-0.007295858,
0.008067662,
-0.0077312347,
0.0043702587,
-0.0012904631,
0.003539085,
0.0029717758,
-0.01009942,
0.02427555,
0.010211563,
-0.021241106,
-0.022296565,
0.00014852695,
0.016504735,
-0.03113603,
-0.006082081,
-0.00875371,
-0.0031251472,
-0.0077180415,
0.032165103,
0.008014889,
-0.00042259577,
0.02236253,
0.0007392334,
-0.051321678,
0.00093507045,
0.0029932149,
-0.0032768694,
-0.022903454,
0.010653536,
0.018905904,
0.0030608303,
0.007902747,
-0.013193234,
0.009400179,
-0.008536022,
-0.015845073,
-0.008160015,
-0.015027093,
-0.0040074447,
-0.020066908,
-0.0069528343,
-0.024842858,
-0.010013664,
0.06786599,
-0.0040470245,
-0.00008616831,
0.0023879753,
-0.021597324,
-0.027573857,
0.0037369835,
0.019182961,
0.011009754,
-0.0030410404,
-0.034566272,
-0.009914715,
-0.00705838,
-0.015093059,
0.02521227,
0.04422372,
-0.011860717,
0.0047000893,
-0.024367902,
-0.010475428,
-0.023892947,
0.032165103,
0.020489091,
-0.017111624,
-0.015132639,
0.001123074,
-0.012117985,
-0.009617867,
-0.014288272,
0.011253828,
-0.025528908,
-0.021386232,
-0.004307591,
-0.0034401356,
-0.010350091,
-0.00705838,
0.0038392309,
0.0033296423,
0.01411676,
-0.0047330726,
-0.013226217,
0.004921076,
0.004921076,
0.019657917,
-0.00891203,
-0.0025479433,
0.025951091,
-0.007553126,
-0.0143806245,
-0.010369882,
-0.011365971,
0.012493992,
0.005452104,
0.0077906046,
-0.005574141,
-0.03248174,
-0.03084578,
-0.027916882,
0.01464449,
-0.0015576262,
-0.00707817,
0.022125052,
-0.0018915798,
-0.004053621,
0.028893182,
-0.16602366,
0.021610517,
0.020212034,
-0.056203175,
0.008417283,
0.0021950242,
0.0059963246,
0.00616124,
-0.0075333365,
-0.010580974,
0.03293031,
0.0035225933,
-0.027969655,
0.014367431,
-0.0050431136,
-0.007196909,
-0.017494228,
0.032059558,
0.009142911,
0.015805494,
0.009855346,
-0.022995805,
0.009980681,
0.013813316,
-0.027837723,
0.030186119,
-0.016148519,
0.03010696,
-0.0026468926,
-0.011009754,
-0.015330537,
-0.009664044,
0.024974791,
0.012658908,
-0.01144513,
0.014657683,
-0.01534373,
-0.01062715,
-0.0038227395,
-0.0002570619,
0.013786929,
0.029816708,
0.0013836403,
0.009736606,
0.009914715,
0.044909768,
0.01815389,
-0.0023385007,
0.00058751117,
-0.013153654,
-0.0024984686,
-0.0038986006,
0.03269283,
0.0067879185,
-0.0021702868,
-0.0069396407,
0.0025924705,
0.0137605425,
0.027389152,
-0.01058757,
0.001353131,
-0.010712906,
0.008536022,
0.0074277907,
-0.018312208,
-0.0036776138,
-0.010831645,
-0.012461009,
-0.0031383405,
0.011306602,
-0.003614946,
0.011121896,
0.012850209,
-0.015462469,
0.025370589,
0.004901286,
0.003862319,
0.01362861,
0.0013193233,
0.00033457216,
-0.008160015,
-0.014829194,
-0.03113603,
-0.0053201714,
0.01994817,
0.024077652,
0.016333222,
0.021847995,
-0.0064251046,
-0.01323941,
0.012586345,
-0.03807567,
-0.0055246665,
-0.0010826697,
0.006662583,
0.0047990386,
0.010106017,
0.0037567732,
0.013786929,
-0.021148754,
0.0012484097,
-0.012375253,
-0.014209112,
0.024288744,
0.00058751117,
-0.010640343,
-0.025449747,
0.0045285774,
-0.004930971,
-0.005666494,
-0.0054026293,
0.01060736,
0.004149272,
0.018549686,
-0.013866088,
0.02778495,
0.01583188,
-0.027494699,
0.025410168,
-0.004673703,
0.021267492,
0.009070348,
-0.021689676,
0.019275315,
0.0052641,
-0.017190784,
-0.10322386,
-0.02505395,
-0.002940442,
0.032956697,
0.020924468,
0.021386232,
-0.011102106,
0.008984592,
-0.034830138,
0.025687225,
-0.02603025,
-0.022784714,
-0.03459266,
0.006471281,
0.010383075,
-0.03472459,
0.026703104,
-0.013094285,
-0.00062750315,
0.03525232,
0.027098902,
-0.02386656,
0.0035654714,
-0.009116525,
-0.0065108608,
-0.020212034,
-0.021570938,
0.0064844745,
0.008846063,
0.0022049192,
0.003967865,
0.0038689158,
0.003016303,
0.00004756779,
-0.02232295,
-0.005613721,
-0.03271922,
-0.012124581,
0.02606983,
0.0029998114,
0.009129718,
0.009050558,
0.011550676,
-0.00967064,
-0.020172454,
0.010376479,
-0.03818122,
-0.02080573,
-0.0030971116,
-0.022758327,
0.007711445,
-0.0035918579,
-0.024948405,
-0.003796353,
0.0032142014,
-0.022494463,
-0.0010092824,
-0.015818687,
0.016834566,
-0.0011428639,
0.008047872,
0.027283607,
-0.015568015,
0.023365216,
0.015079866,
-0.0042943973,
0.00070418883,
-0.0019460019,
-0.020172454,
-0.0376271,
0.009010979,
0.0028596334,
0.0058050225,
-0.00023500447,
-0.022613203,
-0.012441219,
-0.015673561,
-0.001074424,
0.003581963,
-0.020185648,
-0.01062715,
-0.01750742,
0.01370777,
-0.009116525,
-0.009532112,
-0.015660368,
0.018035151,
-0.018193468,
0.0035984544,
-0.022349337,
0.014275079,
0.027389152,
0.030713847,
-0.024301937,
0.0007511897,
0.010231352,
0.008489846,
-0.015304151,
0.009598077,
0.0015873109,
-0.012428026,
-0.010297319,
-0.046387408,
0.010831645,
0.02868209,
-0.021201527,
-0.0054587005,
-0.01632003,
0.0057951277,
0.014604909,
0.004492296,
0.016029779,
-0.016676247,
0.024618573,
-0.016557507,
-0.015475663,
-0.03944777,
-0.017652547,
0.019064223,
0.0045318757,
0.02431513,
0.024697734,
-0.00027211045,
0.018985063,
0.011629836,
0.010007068,
0.0023187108,
-0.007295858,
-0.013971634,
0.025159497,
-0.015858267,
-0.014670876,
0.0062799794,
-0.034750976,
-0.005775338,
0.017441455,
-0.0054191207,
-0.03113603,
0.012526975,
0.013246006,
0.007229892,
0.009861942,
-0.011009754,
-0.003026198,
-0.013918862,
0.0060095177,
-0.009512321,
0.009426566,
-0.005059605,
0.010930594,
0.008067662,
-0.013839702,
0.030924939,
0.018219855,
0.01709843,
-0.013681383,
-0.022758327,
0.0070188004,
0.0030987607,
0.01321962,
-0.0020169155,
-0.0051090796,
0.037231304,
0.00440654,
0.03876172,
-0.010152193,
0.029025113,
-0.023272865,
-0.009921311,
-0.007869764,
-0.0022181123,
-0.033959385,
-0.024222776,
0.00032653252,
0.012025632,
0.0009754747,
0.004630825,
-0.010218159,
-0.0011156528,
0.009452952,
0.012685294,
0.046017997,
-0.0022989209,
0.0041360785,
-0.023470763,
0.020898081,
0.009835555,
-0.011260425,
0.003915092,
0.008938416,
-0.0023582906,
0.0016920322,
0.0036644207,
0.02786411,
-0.0030789708,
-0.003209254,
-0.028497385,
0.030529143,
-0.0033873627,
-0.014235499,
0.027521085,
0.018272629,
0.018576073,
-0.0014265184,
-0.02505395,
-0.015027093,
-0.0044889976,
-0.00032014205,
-0.010356688,
-0.020621024,
-0.0144993635,
0.0017579984,
0.011959666,
0.027204448,
0.014868774,
-0.0071705226,
0.023774207,
0.0024803279,
-0.015211798,
0.007724638,
-0.0076850588,
-0.0012574801,
-0.0050826934,
0.0024011685,
-0.025792772,
-0.007797201,
0.0037732648,
0.013127267,
0.027732177,
-0.0099938745,
0.0247637,
-0.013945248,
0.025146304,
-0.015845073,
-0.028919568,
-0.02374782,
-0.017494228,
-0.002117514,
0.0034599255,
0.0008002521,
0.0007705673,
0.06306366,
0.0077576214,
-0.0044197333,
0.022824295,
0.005006832,
0.033669133,
0.009960892,
-0.01316025,
-0.00232036,
-0.007243085,
-0.010580974,
-0.018246243,
0.00069882907,
-0.02292984,
-0.030238891,
0.028629316,
0.023919333,
0.017243557,
-0.006853885,
-0.034328792,
0.015106252,
-0.012137775,
0.040556,
0.014816001,
0.0024226075,
-0.02019884,
0.03578005,
0.022098666,
0.001721717,
-0.035146773,
-0.011946473,
0.013826509,
-0.02823352,
-0.0042185364,
0.016346416,
-0.02322009,
-0.00036095863,
0.0012310937,
0.025080336,
0.011326391,
0.0055015786,
0.02178203,
-0.01632003,
0.0092550535,
-0.027890496,
-0.016082551,
0.0119728595,
-0.01138576,
-0.036175847
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.