text
stringlengths 174
850
| embeddings_A
sequence |
|---|---|
Zn2+ is present at high concentrations in the synaptic vesicles of hippocampal mossy fibers. We have used Zn2+ chelators and the mocha mutant mouse to address the physiological role of Zn2+ in this pathway. Zn2+ is not involved in the unique presynaptic plasticities observed at mossy fiber synapses but is coreleased with glutamate from these synapses, both spontaneously and with electrical stimulation, where it exerts a strong modulatory effect on the NMDA receptors. Zn2+ tonically occupies the high-affinity binding site of NMDA receptors at | [
-0.012986471,
0.0064831944,
0.01674853,
-0.013180599,
-0.026387973,
0.032506343,
-0.022398315,
-0.015731035,
-0.0075442023,
-0.0046992283,
0.013856699,
0.003270047,
0.0026659083,
0.0024985569,
-0.0042473795,
-0.019399378,
0.021956507,
0.0049971137,
0.012035915,
0.013789758,
-0.008113197,
0.02080513,
0.026428137,
-0.036442447,
0.022612525,
0.018341716,
0.005254835,
-0.014967912,
-0.021474535,
-0.01859609,
0.0026541937,
0.0026023148,
0.0053251227,
-0.004367872,
-0.009672913,
-0.00024642498,
-0.0024935363,
-0.036121134,
0.011547249,
-0.0013739553,
0.0038423887,
0.0053083873,
-0.017832968,
0.004675799,
0.00089951395,
-0.002667582,
-0.0132140685,
-0.005402104,
-0.0026508467,
0.024794787,
0.019011123,
0.019908126,
0.013461749,
-0.008441206,
-0.0036817314,
-0.034916203,
0.016025573,
0.022344762,
-0.0069885957,
-0.023589857,
-0.0127053205,
0.005994528,
-0.029400298,
0.026428137,
0.0074103214,
0.022572361,
-0.00045435913,
0.0228669,
0.00915747,
-0.008668805,
0.015731035,
0.019466318,
-0.010282072,
-0.026401361,
0.038959414,
0.0027612986,
-0.03151562,
0.0073500746,
-0.00434779,
-0.006074857,
0.017444713,
-0.022170717,
-0.009358292,
0.023951337,
0.008026174,
-0.005254835,
0.029989377,
0.006212085,
0.0034256838,
-0.0065836054,
0.005067401,
0.023696963,
0.029266419,
0.03151562,
0.009197635,
0.010877843,
-0.01210955,
0.011975668,
0.010984948,
-0.0035712796,
-0.019760856,
0.0068681026,
-0.009646136,
-0.019988455,
0.00065099704,
-0.024192322,
-0.0020885458,
-0.0027395429,
0.009465397,
-0.00397627,
-0.016320111,
0.04252065,
-0.0065133176,
-0.041155063,
0.012350536,
0.005405451,
0.034059364,
0.0006204554,
0.010630162,
-0.012410782,
0.009672913,
-0.0031646155,
0.023924561,
-0.014325283,
0.024808176,
0.036388896,
0.0068513677,
-0.0019747468,
-0.0029236295,
0.0054556564,
0.0080864215,
0.0228669,
0.026133599,
0.015637318,
-0.016226394,
0.014137849,
-0.007236276,
-0.011661048,
-0.011212545,
-0.035050083,
0.00120242,
0.010984948,
-0.016065737,
0.001137153,
0.010275378,
0.045412485,
0.020764966,
0.014084296,
0.022840124,
-0.0023111233,
0.0033671109,
-0.0052381,
0.0041603567,
0.0040331692,
0.009599278,
0.008059645,
-0.008474677,
0.0060514277,
-0.019975066,
-0.030578453,
-0.012471029,
-0.021889567,
0.0004589613,
0.00029035474,
0.032640222,
0.026227316,
0.030230362,
-0.04233322,
0.0040298225,
-0.025410641,
-0.012558051,
0.016373664,
-0.016815472,
0.032774106,
-0.02258575,
0.01220996,
0.020751577,
0.011774846,
-0.021032728,
-0.02456719,
-0.005475739,
0.018904017,
0.004635635,
-0.0006275679,
0.00052171806,
0.00040603642,
0.043216832,
-0.021354042,
0.0006807019,
-0.027579516,
0.027378693,
-0.005820483,
-0.02862379,
-0.027981158,
-0.64134425,
-0.016266558,
0.004879968,
-0.007865517,
-0.014874195,
0.024259264,
-0.0052113235,
-0.009719771,
-0.0044917124,
0.035826594,
-0.0038356949,
0.019506482,
0.010931395,
-0.037808035,
-0.030283915,
-0.03274733,
-0.0069350433,
-0.019292273,
0.023804067,
0.0069484315,
-0.03507686,
-0.0040432108,
-0.012404088,
0.024580577,
0.023134662,
0.013495219,
-0.003111063,
-0.02499561,
-0.005378675,
0.0392004,
-0.037379615,
0.015570377,
-0.010743962,
0.025611462,
0.04439499,
0.0051912414,
-0.009532337,
0.04035178,
0.0040465575,
0.037245736,
-0.023094498,
0.011948892,
0.015771199,
0.0078855995,
-0.014740314,
0.013675959,
0.000847635,
0.028061489,
0.0022508767,
-0.01082429,
0.017498266,
-0.03159595,
-0.020671248,
-0.0026960315,
-0.00014277169,
0.00034892774,
0.025196431,
-0.007564285,
0.017672312,
0.021179996,
-0.017310832,
0.0075776726,
-0.0036850786,
-0.03721896,
-0.031917267,
-0.008461288,
-0.015021465,
-0.0015714299,
0.007142559,
0.010616775,
0.012685238,
0.011667741,
-0.004762822,
0.0017320873,
0.01547666,
0.0065802583,
-0.008347489,
-0.0042473795,
-0.019787634,
0.017377773,
-0.008193526,
0.00890979,
-0.016668202,
-0.021046115,
0.021313878,
0.037299287,
-0.015516825,
0.0059108525,
0.0060313456,
-0.0014710191,
0.012076079,
-0.002446678,
-0.0070354543,
-0.040217895,
-0.023281932,
0.028007936,
0.003042449,
0.019827798,
0.02441992,
-0.014285118,
-0.028168593,
-0.0076780836,
-0.0029520793,
-0.011640966,
0.0070756185,
0.018970959,
-0.032961536,
0.00816675,
0.049830563,
-0.035799816,
-0.012035915,
-0.0024834953,
-0.010442729,
-0.009773323,
0.010864455,
-0.025169656,
0.01547666,
0.009411844,
-0.015155345,
-0.02583906,
0.008461288,
0.0067074453,
-0.015864916,
0.011915422,
0.004357831,
-0.0036080969,
0.02123355,
-0.022746406,
0.0006802836,
0.0033336405,
-0.00091206527,
0.009612666,
0.014311895,
-0.021340655,
0.022197494,
0.008883014,
0.016480768,
0.0036984666,
0.011346427,
-0.042199336,
-0.00286673,
0.017471489,
-0.0012727076,
-0.026722677,
-0.008347489,
-0.023924561,
-0.0083407955,
-0.0021923038,
-0.014874195,
-0.0035645855,
0.020216053,
-0.016159454,
-0.012484416,
0.0063928245,
0.0069350433,
-0.019305661,
-0.011292875,
-0.0013831595,
0.009706383,
-0.0012283595,
0.0040365164,
0.014967912,
-0.016628038,
0.011379898,
-0.02123355,
-0.038022246,
0.018060567,
0.009170858,
-0.0037754483,
-0.033282854,
-0.0065635233,
-0.023469364,
-0.010770738,
-0.0051912414,
-0.017699087,
0.011968974,
-0.0036984666,
0.004478324,
-0.0074370974,
-0.009144082,
0.004448201,
0.0040666396,
-0.0059610577,
0.00067358953,
0.047019057,
0.006921655,
0.033898707,
0.0030340815,
0.01476709,
0.024901893,
0.0049736844,
0.034407455,
-0.020898847,
-0.009023589,
-0.024111994,
-0.05047319,
0.014111073,
0.0033604167,
-0.0098001,
0.03912007,
0.0046691047,
0.0003832348,
0.020055395,
-0.01168113,
0.019519871,
-0.013227457,
-0.012303677,
-0.010496282,
0.019145004,
0.01654771,
0.0047326987,
-0.01153386,
-0.0116141895,
-0.015208898,
0.0035177271,
0.013267621,
-0.00031692177,
-0.00080747064,
-0.0042339913,
-0.015784588,
0.023241766,
-0.029078985,
0.019519871,
0.0063627013,
-0.01032893,
0.015637318,
0.022907063,
0.02691011,
-0.01405752,
-0.000042805357,
0.0035578914,
0.018796913,
-0.02385762,
0.009438621,
-0.0113598155,
-0.008019481,
-0.009773323,
-0.017458102,
0.036014028,
0.02001523,
-0.006901573,
0.028489908,
0.0017973543,
0.010964866,
0.0021169956,
-0.008019481,
0.008247078,
0.010770738,
0.0003376315,
-0.000116100055,
-0.018087342,
0.0012794017,
0.00573346,
0.0014249975,
0.0006426295,
0.0005079116,
0.012062691,
0.013066799,
0.031194307,
0.027177872,
-0.0049536023,
-0.01732422,
0.02037671,
-0.022518808,
-0.012363924,
-0.00015877467,
-0.005017196,
0.0040766806,
-0.015704257,
-0.029266419,
-0.024915282,
-0.0048264153,
-0.0031244513,
-0.015704257,
0.014633209,
-0.0017739251,
0.0141244605,
0.005847259,
0.015155345,
-0.007296522,
-0.02499561,
-0.022478644,
0.00419048,
-0.0017019641,
-0.008019481,
-0.02542403,
-0.020497203,
0.021889567,
-0.005234753,
-0.0050238897,
0.0033470285,
0.020001844,
-0.017123397,
-0.015597153,
-0.01923872,
-0.031354964,
0.020724801,
-0.0043444433,
0.0038256538,
-0.025825672,
-0.010784126,
0.0052079763,
-0.042788412,
0.010643551,
0.022532197,
0.009773323,
0.009452009,
0.011640966,
-0.008046256,
0.021340655,
0.008240384,
0.003936106,
0.016105901,
-0.028918328,
-0.0005986997,
0.005017196,
0.0031729832,
-0.007818659,
0.037004746,
-0.004960296,
-0.01210955,
-0.04672452,
-0.0036549552,
-0.010643551,
0.018127507,
0.019211944,
-0.01803379,
0.012718708,
0.029453851,
0.005475739,
-0.021956507,
0.002977182,
0.021246938,
0.0018893976,
-0.002153813,
0.016668202,
-0.009083835,
0.0059710993,
0.019225333,
0.01433867,
-0.013655877,
-0.019091452,
0.01640044,
-0.018796913,
0.014311895,
-0.017806193,
0.014137849,
0.015811363,
0.023884397,
0.011353121,
-0.010389177,
0.04045888,
0.023389036,
-0.026120212,
0.027298365,
-0.00089533016,
0.02179585,
-0.012430864,
-0.028704118,
-0.017270667,
-0.016306723,
0.012658462,
0.0041402746,
0.012993165,
0.004916785,
-0.0059242407,
0.01143345,
-0.003214821,
-0.009445314,
-0.016239783,
0.022344762,
0.005499168,
-0.0088495435,
-0.0061886557,
0.03422002,
-0.0116141895,
0.006824591,
-0.015797975,
0.009137388,
-0.0020199318,
0.011292875,
-0.0050908304,
0.007945846,
-0.011721294,
-0.022197494,
-0.0048364564,
0.00480968,
-0.010415953,
0.009364986,
-0.0057970537,
-0.0041703978,
-0.011386591,
-0.0070756185,
-0.022130553,
0.007878905,
-0.02364341,
-0.037165407,
-0.018301552,
0.026896723,
0.022706242,
0.0038825532,
-0.003490951,
0.00025542013,
0.03507686,
-0.009539031,
-0.023121273,
-0.02542403,
-0.01874336,
0.003956188,
-0.00049326837,
0.034996532,
-0.019064674,
-0.004123539,
-0.009739853,
0.0430294,
-0.011580719,
0.017002905,
-0.0069618197,
-0.0008844523,
0.0077985767,
0.012752179,
0.030632006,
0.016199619,
0.0027144402,
0.008247078,
-0.012337147,
-0.022719631,
-0.036951195,
-0.019345826,
-0.0033804988,
0.00047904346,
0.0014626515,
-0.001057661,
-0.0032432708,
0.006302455,
-0.011473614,
-0.007724942,
0.008046256,
0.011105441,
0.018475598,
-0.009539031,
0.031140754,
-0.019037899,
-0.011801623,
0.014311895,
-0.018729972,
0.029935824,
0.003979617,
-0.022478644,
-0.010201743,
0.0051142597,
-0.01569087,
-0.0099406745,
0.017364385,
-0.00887632,
0.03756705,
-0.025263373,
-0.007832047,
-0.009646136,
-0.008588475,
-0.017270667,
-0.0014693455,
-0.015235675,
0.0044883653,
-0.0123907,
-0.0008618599,
-0.03748672,
-0.020135725,
0.0071023945,
-0.03272055,
-0.012537969,
0.01994829,
-0.0043444433,
0.010335624,
-0.0087223565,
-0.010857761,
-0.027579516,
-0.009532337,
-0.011915422,
-0.02846313,
-0.021675358,
0.008421124,
0.018047178,
0.022411704,
0.03223858,
0.011172381,
0.001926215,
0.014847419,
0.011634272,
0.004130233,
-0.00033219258,
0.031006873,
-0.019573424,
0.04152993,
0.016561098,
-0.013709429,
0.035344623,
-0.0046389815,
0.012839202,
0.00986704,
-0.0023161438,
-0.008715662,
0.0016333499,
-0.009478785,
-0.019252108,
0.009773323,
-0.032426015,
-0.009170858,
-0.02577212,
-0.014070909,
0.03719218,
0.009592584,
0.0025320272,
-0.01717695,
0.021916343,
-0.00064388465,
0.0226393,
0.0022960617,
0.005415492,
-0.0015714299,
-0.008180138,
-0.0013429952,
0.0055460264,
0.0045017535,
-0.018020403,
0.011607495,
0.00998084,
-0.005141036,
0.011125523,
0.0048699267,
-0.023777291,
0.012397394,
-0.01711001,
-0.027030604,
-0.049937665,
-0.006874797,
0.003111063,
-0.0495628,
0.021769075,
0.012732097,
-0.011574025,
0.0049636434,
-0.010275378,
-0.001519551,
0.02002862,
-0.0106502455,
0.03917362,
-0.007731636,
0.009525644,
0.0049703373,
-0.009324822,
-0.010469506,
-0.001991482,
0.0007108252,
0.016922576,
0.036040805,
0.0136157125,
-0.01980102,
-0.0004706759,
-0.009880428,
0.0068681026,
-0.0059811403,
-0.021782462,
0.023415811,
-0.005897464,
0.0019613588,
-0.009378375,
0.007504038,
-0.02002862,
0.0042473795,
-0.0128325075,
-0.0041436213,
-0.006791121,
-0.011875258,
-0.024486862,
0.025116103,
0.014419,
0.01661465,
-0.011835094,
0.016012184,
-0.006429642,
0.023830844,
0.009077142,
0.02484834,
-0.008314019,
0.053365026,
0.0021103015,
0.0069885957,
0.0060112635,
0.026013106,
-0.013468443,
-0.01732422,
0.013702735,
0.03357739,
0.0016459014,
0.001609084,
0.020898847,
0.011065276,
-0.024928669,
-0.032934763,
-0.0021220162,
-0.023763902,
-0.031703055,
0.0060982862,
0.024754623,
-0.0009396783,
-0.025825672,
-0.0057635834,
-0.0034507865,
0.00092126965,
-0.028436355,
-0.010255296,
0.006797815,
-0.047019057,
-0.011707906,
-0.015316003,
0.013709429,
0.01945293,
-0.02002862,
0.00036210666,
-0.017096622,
0.0150884045,
-0.018234612,
0.027392082,
0.0141244605,
0.004960296,
-0.016132677,
-0.0038959412,
-0.011754764,
-0.0272582,
-0.007048842,
-0.016909188,
-0.033898707,
0.01994829,
0.0022241005,
0.02164858,
0.029453851,
-0.018622868,
0.02258575,
0.015329391,
0.018154284,
0.010415953,
0.0037754483,
0.010154885,
-0.020390099,
-0.005294999,
0.008548311,
-0.015316003,
-0.032265354,
0.01512857,
-0.01654771,
0.01973408,
-0.00976663,
-0.02443331,
-0.014673374,
-0.012076079,
-0.0064865416,
-0.01902451,
0.01966714,
-0.017417938,
-0.017779415,
0.0036014027,
-0.004321014,
-0.021246938,
-0.023616634,
0.0014090991,
0.026347809,
0.0012944633,
-0.014218178,
-0.0026943581,
0.010228519,
-0.040726643,
-0.058050863,
0.0017337608,
-0.019118227,
0.029400298,
0.0022659383,
-0.018850464,
0.0049870727,
-0.00019193118,
-0.04289552,
-0.004086722,
-0.040325,
-0.003101022,
0.012203266,
0.023683574,
-0.012571439,
-0.01674853,
0.011915422,
0.024272652,
-0.016065737,
-0.0123907,
0.017203728,
-0.0033269464,
0.027284978,
0.028918328,
-0.038852308,
-0.0132140685,
0.03721896,
-0.01575781,
-0.0051979353,
0.026588796,
-0.005495821,
0.002736196,
-0.016802084,
0.010181661,
0.018234612,
0.000175719,
0.03804902,
-0.01512857,
-0.018850464,
-0.017685698,
0.010355706,
-0.020831905,
0.0057736244,
-0.0038356949,
-0.0059141996,
0.011266098,
-0.0043879547,
-0.012671851,
0.03962882,
-0.0149813,
-0.00915747,
0.025116103,
-0.0012743812,
-0.0051042186,
0.021742297,
0.0044113835,
-0.022090388,
0.0067107924,
-0.022478644,
0.00009220018,
0.0045117945,
0.008287243,
-0.0033302936,
-0.010315542,
0.0063627013,
-0.028356027,
0.02037671,
-0.0019496442,
0.0024868422,
-0.030685559,
0.0010702123,
-0.0060246517,
-0.0117413765,
-0.0029721614,
-0.0077784946,
-0.002050055,
0.0020902194,
-0.012357229,
-0.012497805,
-0.006459765,
-0.0127789555,
0.014311895,
-0.017217115,
-0.010918007,
-0.031140754,
-0.00915747,
-0.011312957,
0.011353121,
0.16976129,
-0.004823068,
-0.0009011875,
0.025450805,
-0.00869558,
-0.0018910712,
0.00983357,
0.008334101,
0.008702274,
0.012370618,
0.018823689,
0.016815472,
-0.018663032,
0.0006233841,
0.0050439723,
-0.008026174,
-0.026803005,
-0.022184106,
-0.012471029,
0.0113598155,
0.014218178,
-0.015583765,
0.03826323,
0.0057033366,
0.025035774,
0.0019479706,
-0.009726465,
-0.015717646,
-0.0060313456,
0.013501913,
-0.007483956,
0.01753843,
0.005770277,
0.0125044985,
0.0040499046,
0.0084679825,
0.0059041586,
-0.012926225,
0.008106504,
0.021889567,
-0.0012124612,
0.01433867,
-0.02527676,
0.009498867,
-0.021889567,
0.00073969335,
0.0008802685,
-0.023937948,
-0.007483956,
0.028998656,
-0.028436355,
0.0012860957,
-0.003218168,
0.023094498,
0.011881951,
-0.0048665795,
0.027298365,
-0.0010400892,
0.003211474,
0.020323157,
-0.034193244,
0.0047460864,
-0.005007155,
0.027579516,
-0.0012986471,
0.01760537,
-0.028382802,
0.0047293515,
0.0041068043,
-0.002326185,
0.018984346,
-0.025290148,
-0.015650706,
-0.0030960015,
-0.008541617,
-0.014097684,
0.03223858,
0.00887632,
0.008795992,
0.025544522,
0.00051251374,
0.019225333,
-0.0042373384,
-0.0012626665,
-0.0071760295,
-0.014285118,
0.030417796,
-0.0066003404,
-0.026387973,
-0.0136692645,
0.0073032165,
-0.0035612385,
-0.022384927,
0.0019496442,
-0.007122477,
-0.016815472,
-0.009117306,
0.013307786,
-0.0060246517,
-0.0036315261,
-0.032559894,
0.074330814,
-0.008990119,
0.027713398,
-0.011312957,
-0.01803379,
-0.004468283,
0.0079391515,
-0.00010082924,
0.0015304289,
-0.0014693455,
-0.033818375,
0.0008057971,
-0.019854574,
0.0077851885,
0.011915422,
0.016199619,
-0.027552739,
0.04104796,
-0.010235214,
-0.00022529687,
-0.035103638,
0.0048665795,
0.0075508966,
-0.002183936,
-0.013060106,
-0.026361197,
0.028436355,
-0.010764044,
-0.051008716,
-0.005375328,
0.00961936,
0.020363322,
0.012330454,
-0.01547666,
-0.025370477,
-0.008675498,
0.006526706,
0.020939011,
0.0015714299,
-0.011701212,
-0.015503436,
0.0085215345,
0.0008836156,
0.015650706,
-0.011754764,
0.0046255933,
-0.008220302,
-0.018823689,
-0.01711001,
-0.01427173,
-0.010938089,
0.008240384,
-0.017806193,
0.01291953,
-0.04444854,
-0.01476709,
-0.06378098,
-0.034568112,
0.0037152017,
-0.0226393,
0.0072630523,
0.005315081,
-0.02100595,
-0.01526245,
0.011172381,
-0.16901156,
0.021193385,
0.025825672,
-0.025879225,
0.007691472,
0.0047695157,
0.028838,
-0.0052514877,
-0.0030591842,
-0.010978254,
0.0011279486,
-0.0133613385,
-0.028088264,
-0.016306723,
0.015222286,
0.013481831,
-0.0060313456,
-0.016989518,
0.007229582,
0.0042473795,
0.0035846676,
-0.036603104,
0.03829001,
-0.016721755,
0.025343701,
0.01433867,
-0.009291352,
0.00088612584,
0.012558051,
-0.021822626,
0.00986704,
-0.008996813,
0.019653752,
-0.013040024,
0.037004746,
0.00332862,
0.002794769,
-0.01569087,
0.0002443331,
0.03202437,
0.023482753,
0.023241766,
-0.0010643551,
-0.015864916,
-0.019064674,
0.0058807293,
0.005602926,
-0.0073433807,
-0.008749133,
-0.0077851885,
0.024018276,
-0.0011605822,
0.004103457,
0.02243848,
0.025116103,
0.009592584,
-0.009452009,
0.007109089,
-0.0043611783,
0.0039996994,
0.0057970537,
-0.03558561,
0.018823689,
0.0066170758,
-0.0023412465,
-0.03095332,
-0.0010727227,
-0.008026174,
-0.034889426,
-0.0039160233,
-0.009545726,
-0.0067308745,
0.024701072,
-0.02684317,
0.023509528,
0.019252108,
0.0063693956,
0.0045519588,
0.01796685,
0.021327266,
-0.032854434,
0.0039494936,
-0.039521713,
-0.027164483,
-0.014311895,
0.0023345524,
0.026428137,
-0.002274306,
0.014686761,
0.025196431,
-0.000961434,
-0.0234292,
0.028704118,
-0.023710351,
0.023322096,
0.0035712796,
0.014686761,
0.01131965,
0.005897464,
0.009257881,
0.031997595,
0.007718248,
-0.012484416,
-0.011587413,
0.033363182,
0.028034711,
0.010449423,
0.026307644,
0.029186089,
-0.010409259,
0.0018157631,
0.005489127,
-0.00012760547,
0.028061489,
0.00041691426,
0.027244814,
0.022264434,
-0.0056866016,
0.026508467,
-0.0074170153,
0.061745983,
-0.026776228,
0.0009011875,
0.008474677,
-0.013368032,
-0.028382802,
-0.1330243,
-0.024245875,
0.013019942,
0.024982221,
0.0041871327,
-0.014780479,
0.0044013425,
0.034407455,
-0.0015120201,
0.053900547,
-0.013394808,
0.007236276,
0.025477583,
0.003293476,
0.00029432934,
0.00940515,
0.0019847879,
0.0038290008,
-0.038102575,
0.0299626,
-0.026441526,
0.0027780337,
-0.0012417476,
-0.0010141496,
0.00548578,
0.007611143,
-0.01334795,
0.037031524,
-0.0073166047,
-0.0023696963,
0.021889567,
-0.019573424,
0.004782904,
-0.0038792063,
-0.027231425,
0.005499168,
0.031087201,
0.0071961116,
0.05489127,
0.00051418727,
-0.016802084,
0.011808317,
0.020858683,
0.0025403947,
-0.0017136786,
0.0059008114,
-0.02044365,
0.00067400787,
0.017940074,
-0.016628038,
-0.042413548,
0.006412907,
-0.025584687,
-0.0123237595,
0.039709147,
-0.0017889868,
-0.007591061,
0.026213927,
-0.03047135,
0.0035846676,
0.013588936,
0.013548772,
0.013220763,
-0.013013247,
0.02747241,
-0.00034307042,
-0.022505421,
-0.041503154,
0.005867341,
-0.034166466,
0.0068346323,
0.018288163,
-0.02001523,
-0.010188355,
-0.048518527,
0.025611462,
0.0067710388,
0.0037921835,
0.019359214,
-0.003352049,
-0.008032869,
-0.011915422,
-0.0074370974,
-0.002277653,
0.009277963,
0.0077718003,
0.015516825,
0.0005451473,
0.0023680227,
-0.035532057,
-0.023268543,
0.022344762,
-0.009840264,
-0.0024583924,
-0.005633049,
0.007865517,
-0.004705922,
0.0039260644,
0.018475598,
0.022719631,
-0.006704098,
-0.034514558,
-0.045385707,
0.009318127,
0.0016475748,
-0.023522917,
-0.013762982,
-0.014111073,
0.008949954,
-0.009967451,
0.00795254,
-0.013696041,
-0.019854574,
-0.018930795,
0.0026207233,
0.0034307044,
-0.03550528,
-0.0013865066,
0.038879085,
-0.016253171,
-0.0015797975,
0.021407595,
-0.0045988173,
0.021273714,
0.0028516683,
0.024915282,
-0.013963804,
-0.0074237096,
-0.026883334,
-0.0014074255,
-0.012812425,
-0.00037193854,
0.015945245,
-0.036442447,
-0.014673374,
0.007751718,
-0.015771199,
-0.016922576,
0.0054322276,
0.008990119,
0.0058004004,
0.027445635,
-0.020095559,
-0.017618759,
-0.006804509,
0.0109046195,
-0.0067174863,
-0.012999859,
-0.026120212,
0.0113598155,
0.004585429,
-0.020764966,
0.009913899,
0.010148191,
0.023683574,
-0.022666078,
-0.013816535,
0.0033068643,
0.008755826,
0.016132677,
-0.016132677,
-0.021568252,
0.0082671605,
0.0013973844,
0.012270207,
0.009411844,
-0.015008076,
-0.0040499046,
-0.024942057,
-0.0038423887,
0.014204789,
-0.016949354,
-0.021635193,
-0.025169656,
0.020403486,
0.0118685635,
-0.01202922,
0.006419601,
-0.011098747,
-0.0047326987,
-0.019908126,
0.021661969,
-0.004782904,
-0.0054690447,
-0.021675358,
0.019292273,
0.03031069,
-0.0049669906,
0.0072429697,
0.015396331,
0.013294398,
0.0138700865,
0.006202044,
0.0150884045,
0.009003507,
0.000054389217,
0.009679607,
0.010703797,
-0.0066036875,
-0.0069952896,
0.007477262,
0.0028366067,
-0.018877242,
0.0075575905,
0.00046440022,
-0.015021465,
0.011045194,
0.013167211,
-0.04651031,
-0.045680247,
0.0039294115,
0.010677021,
0.025825672,
-0.0013831595,
-0.004545265,
-0.0042674616,
-0.0148340305,
0.024446696,
-0.011460226,
-0.0061317566,
-0.01220996,
0.01711001,
0.008963343,
0.021528088,
0.025196431,
0.00044975698,
0.024982221,
0.004080028,
0.03004293,
-0.015490049,
0.0148340305,
-0.013327868,
0.017993625,
-0.0040197815,
-0.034916203,
-0.012631686,
0.002160507,
0.0025320272,
-0.011881951,
0.020550756,
0.0043344023,
0.09639443,
0.0057066837,
-0.008173444,
-0.005542679,
-0.017940074,
0.01310027,
-0.008454594,
0.030685559,
-0.002043361,
-0.033068642,
0.01917178,
-0.026133599,
0.032827657,
-0.0014224872,
-0.010456118,
0.0110385,
-0.019345826,
0.02484834,
-0.008996813,
-0.03095332,
0.015570377,
-0.0163335,
0.012290289,
-0.004806333,
-0.012691933,
0.014137849,
0.05821152,
-0.008226996,
-0.010154885,
-0.017404549,
-0.015155345,
-0.011413367,
-0.02867734,
0.00063217,
-0.022317987,
-0.0017270668,
-0.015811363,
-0.011292875,
0.0022609178,
0.021300491,
-0.002046708,
0.027351918,
0.0025755386,
-0.0005643927,
0.018850464,
-0.0028098305,
-0.021099668,
-0.021715522,
-0.03812935
] |
The aim of the present investigation was to study the effect of a dietary intervention which combined nutrition information with increased availability of vegetables, fruits and wholegrain bread. The effect of the intervention was determined by changes in the intake of vegetables, fruits, wholegrain bread and estimated nutrients. Furthermore, the study investigated whether changes in relative contribution from different food sources of folate were related to changes in the concentration of plasma total homocysteine (p-tHcy). The 5-month intervention study included 376 male recruits from the Norwegian National Guard, Vaernes (intervention group) and 105 male recruits from the Norwegian National | [
-0.003980605,
-0.01773671,
0.033740368,
0.0035608814,
0.0003621809,
-0.003391638,
-0.0031428502,
-0.01827829,
-0.032413498,
-0.022028724,
0.002174778,
0.0012177064,
-0.0059505985,
0.026131183,
-0.019957183,
0.019253131,
0.043542948,
-0.016003657,
-0.013999815,
-0.017005578,
-0.028703684,
0.0137628745,
0.0088006575,
0.011224223,
-0.0020529227,
0.022015184,
0.008638184,
-0.04213484,
-0.008414783,
0.007060835,
0.0061638453,
0.008760039,
0.0009181455,
-0.023396209,
0.0041566184,
-0.025318814,
-0.010256151,
0.0035168782,
0.028893236,
-0.015177749,
0.0121719865,
0.0003465259,
0.0032139325,
0.0019395296,
-0.019645775,
-0.006380477,
0.003251166,
0.0004417253,
-0.039724816,
0.024547065,
0.023626382,
0.013045282,
-0.0046914276,
0.01875217,
-0.0072029997,
0.0110279005,
-0.0010188454,
0.024371052,
-0.014663249,
-0.013146829,
-0.0061266115,
0.0096265655,
-0.024343973,
0.011718414,
-0.0138914995,
-0.0041159997,
-0.0013624094,
0.007270697,
-0.00077048066,
0.031709448,
0.007148842,
0.04316384,
-0.005605342,
0.0029262186,
0.028216261,
0.013945658,
-0.029516052,
-0.018819869,
0.015732868,
0.0061029177,
0.026063485,
-0.014730947,
-0.011481473,
0.029922236,
0.012632328,
-0.004853901,
-0.012618789,
0.024587683,
0.018955262,
-0.013458236,
-0.007480559,
-0.0036353485,
0.015394381,
0.009172993,
-0.018197052,
0.024398131,
-0.018643854,
0.023721157,
0.0043800194,
-0.020932026,
-0.01930729,
-0.01286927,
-0.016071355,
-0.009646875,
-0.023247276,
-0.017262828,
-0.018995881,
-0.0069457497,
0.015001737,
-0.027674682,
-0.017899184,
0.025562525,
-0.017899184,
-0.046413314,
-0.0000020147238,
-0.0066715754,
-0.011427315,
-0.0056662695,
-0.0055376445,
0.0012642483,
0.009179763,
-0.00654972,
0.02698417,
0.0027959011,
0.015367302,
0.016220288,
-0.02569792,
-0.0048945197,
-0.010120756,
-0.013316072,
0.0037233552,
0.0069186706,
0.030165946,
-0.0047354307,
-0.036881525,
0.026618604,
-0.031384498,
-0.011203914,
-0.028297499,
-0.026659222,
0.017073276,
0.025833314,
-0.012002743,
-0.0252105,
-0.027525749,
0.0102629205,
0.027430972,
0.04698197,
-0.007480559,
-0.02003842,
0.003158082,
-0.004271704,
0.036827367,
0.002276324,
0.020390447,
-0.0049486775,
-0.022164118,
0.015841184,
-0.026659222,
-0.0016983576,
0.012997895,
-0.025725,
-0.0012447853,
0.0027011249,
0.008028908,
0.019848868,
0.004982526,
0.002755283,
-0.0063398583,
-0.010384776,
0.004677888,
0.026158262,
-0.039751895,
-0.0024032565,
-0.007392552,
-0.0027282038,
0.0010010748,
0.0022797089,
-0.00925423,
-0.014108131,
-0.020431066,
0.026361354,
0.028135026,
0.006502332,
0.002993916,
0.0007273236,
0.030084709,
-0.0045661875,
-0.013404079,
-0.007879973,
0.006857743,
0.021013262,
-0.0059573683,
-0.021920407,
-0.6594265,
-0.0010433857,
0.016057815,
-0.0052567003,
0.03598792,
0.035446342,
0.020959105,
0.0021392368,
-0.008374164,
0.017086815,
-0.001033231,
0.04297429,
0.004552648,
-0.012253223,
0.008272618,
-0.021988105,
-0.010330618,
-0.020376908,
0.022678617,
0.012821881,
-0.024113802,
0.026523829,
-0.006529411,
0.0032105476,
0.035879605,
0.040320553,
0.008360624,
0.00054877176,
-0.010310309,
0.011386697,
-0.011183605,
0.03162821,
0.00027227035,
0.020512301,
0.045655105,
-0.020972645,
-0.011907967,
0.0097755,
0.005422559,
0.0068238946,
-0.012889579,
-0.024899092,
0.020999722,
0.009701032,
-0.010696184,
0.025129262,
0.016084895,
0.004302168,
0.014852802,
-0.00094099337,
0.009294848,
0.010357697,
-0.011352848,
-0.01413521,
0.028432894,
-0.012666177,
0.027024789,
-0.023030644,
0.011840269,
0.008712651,
-0.017506538,
0.019686393,
-0.02546775,
-0.019198973,
-0.009315157,
0.009660414,
-0.00024497983,
0.012700026,
0.0028720608,
-0.0029025245,
0.016423382,
0.02619888,
0.011095598,
0.00021610268,
0.05006897,
-0.0012354769,
0.03238642,
0.019483302,
-0.01776379,
0.026022868,
0.007859664,
-0.0064414046,
-0.00795444,
0.01849492,
0.02496679,
0.004850516,
-0.022786934,
-0.008245539,
-0.015854724,
-0.028459974,
0.007582105,
0.02236721,
-0.0037402795,
-0.013322841,
-0.019591618,
0.02002488,
-0.0015265757,
-0.00080475246,
0.01593596,
-0.029759763,
-0.019957183,
0.0074467105,
0.014514315,
0.014405999,
0.01052694,
0.008428322,
-0.012165217,
0.008347086,
0.022258895,
-0.023734696,
0.007771658,
-0.0009071447,
-0.015800565,
0.0037673584,
-0.005422559,
-0.029678525,
0.0020986183,
-0.004860671,
-0.019334368,
-0.017669013,
0.03720647,
0.010628486,
0.0060013714,
-0.007020217,
0.0062383125,
0.035094313,
0.0002688855,
-0.024140881,
-0.02208288,
-0.00901729,
0.011630408,
0.028568288,
0.016680632,
-0.0070811445,
0.02083725,
-0.0043800194,
0.028324578,
-0.011623638,
-0.014108131,
-0.039508183,
-0.030057631,
-0.0024997252,
0.002030921,
-0.007392552,
0.008191382,
-0.010892506,
-0.0049960655,
-0.0021578535,
-0.0011779341,
0.0017635163,
0.0200655,
-0.010824809,
-0.03268429,
0.006505717,
0.00030421503,
-0.0044138683,
-0.023084803,
-0.038831208,
0.011928276,
-0.017655473,
0.019442683,
0.03311755,
0.022055801,
-0.018616775,
-0.008936052,
-0.015814105,
-0.011014362,
0.013085901,
0.008022138,
-0.021514222,
0.031709448,
-0.019659314,
-0.013810263,
0.015096513,
-0.015272526,
0.024330433,
-0.033469576,
0.017181592,
-0.010147835,
-0.0007692113,
-0.00327486,
-0.024506446,
-0.02546775,
0.0061807693,
0.0008952977,
0.0018769095,
0.022962946,
0.022841092,
-0.013505625,
0.033252947,
-0.0025775773,
0.00072647736,
0.0072029997,
0.008374164,
-0.023518065,
-0.0026520444,
-0.0123006115,
-0.017560696,
-0.0023203273,
0.008462171,
0.02981392,
-0.006014911,
0.017520078,
-0.005981062,
0.036285788,
-0.016315065,
0.007094684,
0.0076768813,
0.016003657,
0.0012092442,
0.0136680985,
-0.009139145,
-0.012923427,
-0.005679809,
-0.011420546,
-0.011454394,
-0.0034830295,
-0.015597473,
-0.026185341,
-0.00043622492,
-0.00076413405,
-0.009355776,
0.033902843,
0.008502789,
-0.007812276,
0.025833314,
0.006475253,
0.017669013,
-0.0013615632,
-0.021460066,
0.002019074,
0.0128083415,
-0.011630408,
-0.009802579,
0.02854121,
-0.011786112,
0.010878967,
-0.026645683,
0.026605064,
0.029949315,
0.016477538,
0.029651446,
-0.0002405372,
-0.0021104654,
0.025061565,
-0.010235841,
0.030111788,
0.0098499665,
-0.010053059,
0.020742472,
0.014893421,
0.02258384,
-0.01285573,
-0.031086631,
-0.005706888,
0.01566517,
-0.0018752171,
-0.002946528,
0.004633885,
0.026347814,
0.03365913,
0.024371052,
-0.0022424753,
0.0028822154,
-0.026022868,
0.0054970263,
-0.005480102,
-0.001099236,
-0.031709448,
0.00096891855,
-0.015150671,
-0.025873933,
0.009613026,
0.002198472,
0.016626474,
-0.0079070525,
0.01879279,
0.02927234,
0.013580091,
-0.0051991576,
-0.035879605,
-0.010120756,
0.019578079,
0.035310946,
0.0036082696,
-0.014879881,
0.0018599852,
0.00048699792,
-0.0051213056,
-0.014284144,
0.000046224606,
-0.00629924,
0.023585763,
0.008428322,
0.0007429786,
0.003675967,
-0.0005475024,
-0.006390631,
0.033956997,
0.00693898,
-0.0024861859,
0.00053353986,
-0.030545052,
-0.015313144,
0.046900734,
0.008773578,
-0.014284144,
-0.015191289,
0.014175829,
-0.021690236,
0.007223309,
0.013024974,
0.0033594817,
-0.008631414,
0.0023914094,
0.012287072,
-0.0080356775,
-0.0062924703,
0.012307381,
-0.009112066,
-0.007345164,
-0.04960863,
-0.023179578,
0.005842283,
0.048498392,
0.022678617,
0.003936602,
-0.003442411,
0.02156838,
0.0014749564,
-0.012422467,
-0.015827645,
0.010858658,
-0.017723171,
0.02056646,
0.008320007,
0.017316986,
-0.015204828,
-0.011129447,
0.003290092,
-0.0044544865,
-0.032413498,
-0.004644039,
-0.0028585212,
-0.00021155427,
-0.014582013,
0.013823803,
0.026347814,
0.02594163,
0.0021883172,
0.022434907,
0.04419284,
0.012747414,
-0.005375171,
0.0031293107,
0.011819961,
-0.008414783,
-0.006891592,
-0.026307197,
-0.020390447,
0.0010425395,
-0.0025284966,
0.0015011891,
-0.0024506447,
0.0075753354,
-0.0039027531,
-0.0047895885,
-0.0069592893,
-0.010411855,
-0.014825723,
0.010730033,
0.021663157,
-0.030382577,
-0.02724142,
0.014920499,
-0.006008141,
0.0009274539,
-0.008435092,
0.011731953,
-0.021771474,
0.023964867,
-0.0065734144,
0.0037436644,
-0.016612934,
-0.0131265195,
-0.020918487,
0.0416745,
-0.008963131,
-0.020986183,
0.010499861,
-0.023287894,
-0.008732961,
0.0044815657,
0.02183917,
-0.0015316529,
-0.026049947,
-0.02053938,
0.0120772105,
0.015854724,
0.00038608655,
0.030165946,
0.0010400008,
-0.004518799,
0.015313144,
-0.03912908,
-0.011366388,
0.0034441035,
0.0074128616,
-0.01001244,
-0.01386442,
-0.013404079,
-0.02181209,
-0.007426401,
0.0088615855,
-0.015475618,
0.00017908069,
-0.00028686758,
-0.011704874,
-0.016626474,
-0.0055308747,
-0.007785197,
0.011718414,
0.011176835,
-0.0021967795,
0.004386789,
-0.0065869535,
-0.019835329,
-0.027078947,
0.0058693616,
0.0020376907,
-0.0098161185,
-0.026104104,
0.011901197,
-0.0016399687,
0.035446342,
-0.010249381,
-0.008387703,
0.015475618,
0.026672762,
0.04941908,
-0.0047455854,
0.0003719124,
0.014568473,
-0.01849492,
0.0074128616,
-0.005185618,
0.025779158,
-0.02079663,
-0.027837157,
0.015015276,
0.007047296,
-0.039237395,
-0.017398223,
0.0036895066,
-0.0018092121,
0.02671338,
-0.0030988469,
-0.021663157,
-0.006986368,
-0.013783184,
-0.022042263,
0.0022864786,
-0.008265848,
-0.031546973,
-0.016260907,
-0.02724142,
-0.003356097,
-0.01259848,
0.015570394,
-0.026618604,
0.0030988469,
-0.005432714,
-0.010405085,
0.024343973,
0.0011897812,
-0.00795444,
-0.02056646,
0.008008598,
-0.023490986,
-0.023396209,
-0.032711368,
-0.0034644126,
0.035338026,
0.016166132,
0.039724816,
-0.0150694335,
0.0074196314,
-0.01105498,
0.0071149934,
0.004644039,
-0.016125513,
0.002966837,
-0.028324578,
0.015529776,
0.023179578,
0.00848248,
0.00096807233,
-0.0042243158,
-0.0007332471,
0.03780221,
-0.021622539,
-0.0018735246,
-0.009585947,
-0.032982156,
0.00045357234,
-0.015218368,
-0.017804407,
-0.0036319636,
-0.021189276,
-0.027810078,
0.012957276,
0.014216447,
0.02232659,
-0.013593631,
0.005260085,
-0.023314973,
0.013295762,
0.011318999,
-0.009064677,
0.0010044597,
-0.0028585212,
-0.0015011891,
-0.021365289,
0.028216261,
0.024777235,
0.0067054243,
-0.011576249,
-0.021730855,
-0.008320007,
0.0029973008,
-0.010858658,
-0.008272618,
0.0015951192,
-0.0033036314,
-0.020864328,
0.008773578,
-0.0049486775,
0.0063838614,
0.004843747,
0.0025200346,
-0.018806329,
0.0064989473,
-0.011799651,
-0.00900375,
-0.006434635,
-0.009166223,
0.043759577,
-0.021649618,
0.024357513,
0.02131113,
-0.017493,
-0.029191105,
0.032982156,
0.011115908,
-0.0017127433,
0.019632237,
0.0072029997,
0.004173543,
-0.023666998,
-0.010093677,
0.015583933,
-0.014852802,
-0.027146643,
0.030355498,
0.01952392,
0.0058998256,
-0.00975519,
0.013918579,
-0.024140881,
0.030355498,
0.01849492,
0.0023287893,
0.012964046,
-0.006045375,
0.0024811085,
0.03371329,
-0.018427223,
0.019361448,
-0.008509559,
-0.008915743,
0.0038316709,
-0.023274355,
-0.028107947,
0.012510473,
-0.0152589865,
0.035365105,
0.015137131,
0.015624552,
-0.011061749,
-0.015299605,
0.005832128,
-0.0006346628,
-0.01643692,
0.032548893,
0.0050502233,
-0.0074670194,
0.021473605,
0.013437927,
0.017966881,
-0.007324855,
0.0010501554,
-0.024276275,
-0.036312867,
-0.012138138,
0.012185526,
0.009349006,
-0.022380749,
0.0056222663,
-0.01130546,
-0.00094945554,
-0.029678525,
-0.0066140327,
0.013525934,
-0.013681638,
-0.022516144,
-0.004390174,
0.017669013,
0.018318906,
-0.0049148286,
-0.02129759,
-0.011833499,
0.032223947,
-0.02749867,
-0.001200782,
0.0027891316,
0.002323712,
-0.017168052,
-0.01619321,
-0.023463907,
-0.027945472,
0.018115815,
-0.022570303,
-0.04603421,
-0.02747159,
-0.0071826903,
0.013167137,
0.0100395195,
-0.012781262,
0.029136946,
0.006658036,
0.00604199,
0.011352848,
-0.011684566,
0.0006562413,
-0.017316986,
-0.0035676511,
0.014229987,
-0.0047929734,
0.012903118,
-0.009200072,
0.0065869535,
0.0032697828,
-0.02827042,
-0.00033933306,
-0.025779158,
0.020904947,
-0.006729118,
0.013722256,
-0.012422467,
-0.0066241873,
-0.017628394,
-0.006319549,
0.013566552,
-0.029868077,
-0.0073857824,
0.0031174638,
-0.0035134933,
0.0010628486,
-0.014162289,
-0.00822523,
-0.016788946,
-0.016044276,
-0.011955355,
0.007873204,
-0.009064677,
0.023829473,
0.024831394,
-0.02156838,
0.0031208487,
0.0028686759,
-0.045357235,
-0.015800565,
0.019754091,
-0.0008305621,
-0.005060378,
-0.007473789,
-0.0062315427,
0.029109867,
-0.023314973,
0.011508552,
-0.0066648056,
-0.008922513,
0.015719328,
0.0070269867,
0.027051868,
-0.006448174,
-0.045844655,
-0.006735888,
0.006732503,
-0.011711644,
-0.0012760954,
0.016003657,
0.018725092,
0.016937882,
-0.015570394,
0.010127526,
0.019496841,
-0.02900155,
0.008726191,
-0.0016171208,
-0.011928276,
-0.019957183,
-0.0041532335,
-0.013823803,
-0.016531697,
-0.0075347167,
-0.00899698,
0.017831486,
-0.03758558,
-0.034823526,
0.020471683,
-0.034606893,
0.0018735246,
0.01905004,
-0.0011897812,
-0.0029059094,
0.018061657,
-0.0075008683,
-0.0021493915,
0.012002743,
-0.0093083875,
-0.010696184,
0.008292927,
-0.011522092,
-0.0070540654,
-0.009261,
0.023328513,
-0.016409842,
0.0123953875,
-0.011454394,
-0.018400144,
-0.00795444,
0.011731953,
-0.02002488,
-0.0010958511,
-0.008942822,
0.005933674,
-0.0031682367,
0.0137019465,
-0.010120756,
-0.0076498026,
-0.030924156,
-0.0041769273,
0.00976873,
-0.013038512,
0.010757111,
0.030193025,
0.0033002465,
-0.021108039,
0.01052694,
0.18467842,
-0.0019446069,
0.014609092,
0.016856644,
-0.00082506164,
0.016653553,
0.028459974,
0.0023101727,
-0.020877868,
0.017371144,
0.009660414,
0.007521177,
-0.01592242,
0.0006067376,
0.021419447,
-0.022719236,
-0.013823803,
-0.019320829,
-0.0041227695,
0.015218368,
0.0098161185,
-0.010398315,
-0.006847589,
-0.012192296,
0.013234835,
-0.00035773826,
-0.019618697,
0.008489249,
0.02749867,
-0.0044003287,
-0.008394473,
-0.0125240125,
-0.011691336,
0.003235934,
0.015502697,
0.009193302,
0.0055444143,
-0.005134845,
-0.0090849865,
-0.018088736,
-0.0009105296,
0.0011034671,
-0.02848705,
-0.01310621,
-0.00900375,
0.012158447,
-0.00080602174,
-0.01284896,
-0.0064854077,
0.008949592,
-0.027810078,
-0.009870276,
0.021690236,
0.018142894,
-0.0069085164,
0.004847131,
0.03187192,
-0.020688316,
0.001337023,
0.023626382,
-0.00900375,
0.01877925,
-0.00975519,
0.03574421,
-0.011819961,
0.020756012,
-0.029949315,
-0.0074467105,
-0.019117735,
-0.0012845575,
0.012801572,
-0.010689414,
-0.0061570755,
0.025142802,
-0.023233736,
-0.005507181,
0.030165946,
0.026875854,
0.022191197,
0.029353578,
-0.01722221,
-0.012794802,
-0.0071826903,
0.0051991576,
-0.01879279,
-0.023423288,
0.009707802,
-0.006380477,
-0.009315157,
-0.013695178,
0.023761775,
-0.00022445907,
0.0042547793,
0.000892759,
0.0001586657,
-0.017154513,
-0.008340316,
0.0049757566,
-0.0011559326,
-0.0066749603,
-0.029164026,
0.062823154,
-0.009091756,
0.02466892,
-0.02698417,
0.0059472136,
-0.029082788,
0.026401972,
-0.00642448,
-0.010675875,
-0.0025606528,
-0.025075104,
0.005679809,
-0.015732868,
0.017696092,
0.010689414,
-0.0046068057,
-0.024777235,
0.026645683,
-0.014825723,
0.016098434,
-0.015949499,
0.0028348272,
0.053562157,
-0.03598792,
-0.0094031645,
-0.027363276,
0.0054124044,
-0.0067900456,
-0.012666177,
-0.00034060236,
-0.030138867,
-0.007731039,
0.0037098157,
0.0071149934,
0.01052017,
-0.0015096513,
0.0077513484,
0.003574421,
0.0006934749,
-0.013722256,
-0.022313053,
0.0014783412,
0.0039129076,
-0.0068780524,
-0.041268315,
0.014175829,
-0.0032173174,
-0.020227972,
0.003936602,
0.0014961117,
-0.0070269867,
-0.0039433716,
-0.01233446,
0.018738631,
-0.016328605,
-0.011779342,
-0.03658366,
0.0038587498,
0.01001921,
-0.010452474,
0.015759947,
0.02900155,
-0.0077919667,
-0.0034356413,
0.022380749,
-0.17319694,
0.03290092,
0.022123499,
-0.036150392,
0.04654871,
0.002751898,
0.018643854,
0.02029567,
-0.013559783,
0.017019117,
0.01953746,
0.0063127796,
-0.043028444,
-0.017641934,
0.020634158,
0.0092136115,
-0.018968802,
0.033848684,
0.011847039,
0.009552099,
0.002404949,
-0.0037639735,
0.0033340952,
-0.00045780343,
0.014338302,
0.033036314,
0.016139053,
0.01054048,
-0.008116914,
0.0029600672,
0.017100355,
0.013546243,
0.031032473,
-0.010141065,
-0.0027315887,
-0.027579907,
-0.0110279005,
-0.008347086,
0.0013200986,
0.007636263,
0.024479367,
0.023951327,
-0.0025538832,
0.005469947,
-0.019117735,
0.014893421,
-0.0054056346,
-0.035771288,
0.0012303996,
0.0007281698,
0.03211563,
-0.0018650624,
0.03371329,
0.019578079,
0.012835421,
-0.01078419,
-0.012517243,
-0.015516236,
0.009206842,
0.014026894,
-0.0038993682,
-0.021757934,
0.016220288,
0.007758118,
-0.0026689686,
-0.030138867,
-0.024750156,
-0.022258895,
-0.0054157893,
-0.004214161,
-0.028135026,
-0.0062450822,
0.026320737,
-0.0004954601,
0.01361394,
0.016585855,
-0.02594163,
-0.007995059,
0.0011280073,
0.001746592,
0.011481473,
-0.008360624,
-0.04259518,
-0.018197052,
-0.003523648,
0.0005991217,
0.023342052,
0.016531697,
-0.0083538545,
-0.0055444143,
0.010438934,
-0.025007406,
-0.0088954335,
-0.017885644,
0.005811819,
0.027701762,
0.024519986,
0.012070441,
-0.00927454,
-0.014974657,
0.012774493,
-0.015042354,
-0.031167867,
0.011664256,
0.018169973,
-0.018102275,
-0.019253131,
0.012740645,
0.04210776,
-0.011163295,
-0.010398315,
0.004732046,
-0.0020089194,
0.022516144,
-0.0002784054,
0.02442521,
0.011021132,
-0.015055894,
0.01850846,
0.00055765704,
0.043299235,
0.012050131,
0.00043876356,
0.010181684,
0.004166773,
-0.017574236,
-0.12911242,
-0.00063297036,
-0.003188546,
0.030788762,
0.015556855,
0.011772572,
-0.004650809,
-0.019754091,
0.0031817763,
0.017709631,
-0.021676697,
-0.01876571,
-0.008875125,
-0.027024789,
0.029868077,
-0.009646875,
-0.015773486,
-0.006803585,
-0.017005578,
0.01773671,
-0.01775025,
-0.021920407,
0.005219467,
-0.0140810525,
0.0037741282,
0.008760039,
-0.014338302,
0.010818039,
0.015434999,
0.020742472,
0.016301526,
-0.007819045,
0.008516328,
-0.01930729,
-0.020756012,
-0.013092671,
0.0010696184,
-0.018928183,
0.02262446,
-0.024872012,
0.0092136115,
0.001598504,
0.025521908,
-0.027146643,
0.035825446,
-0.0015189596,
-0.03750434,
0.009904125,
-0.0056730392,
-0.011698104,
-0.020688316,
-0.010235841,
-0.021432986,
-0.0035913452,
0.014961118,
0.007473789,
-0.0008627183,
-0.012544322,
-0.024140881,
-0.0067798914,
-0.009897355,
0.017493,
-0.040699657,
0.021365289,
0.022746315,
0.0012676332,
-0.046413314,
-0.03420071,
0.0018345986,
-0.016139053,
0.0036251938,
0.009822887,
-0.0010713108,
-0.005557954,
-0.02599579,
0.0034593353,
-0.03317171,
-0.013810263,
0.006065684,
-0.019117735,
-0.00795444,
-0.026104104,
0.021378828,
-0.0038925984,
-0.0007404399,
0.0011043133,
0.0006748581,
0.013708716,
0.008502789,
-0.0065767993,
-0.001239708,
0.032955077,
0.025251118,
-0.0044409474,
-0.012368308,
0.013288993,
-0.0050739176,
0.00025428823,
0.020715393,
-0.013695178,
-0.021405907,
-0.004644039,
-0.054320365,
0.013004664,
-0.0012870962,
-0.010418625,
0.0032934768,
0.0018498305,
0.010554019,
0.015177749,
-0.010310309,
0.032792605,
-0.019848868,
0.02775592,
-0.02133821,
0.009721342,
-0.020444604,
-0.009856736,
0.02875784,
0.011461164,
0.033361264,
0.035283867,
0.007879973,
0.013932118,
0.008055987,
0.019496841,
-0.022895249,
0.0025589603,
-0.0022627844,
0.019930104,
-0.0035371874,
-0.008665263,
0.015489157,
-0.019212512,
-0.023017105,
0.0060859933,
-0.0051280754,
-0.025156341,
-0.026334275,
0.016409842,
0.02468246,
0.028595367,
0.0019209128,
-0.015272526,
-0.0086720325,
-0.011197144,
-0.00073620887,
0.023504525,
-0.02181209,
0.010432164,
0.00424124,
-0.006759582,
0.033577893,
0.002970222,
0.0036421183,
-0.01854908,
-0.015516236,
0.0071623814,
-0.011163295,
0.003804592,
-0.004596651,
-0.023653459,
0.008523098,
-0.017845025,
0.009728111,
0.0028483667,
0.007230079,
-0.020227972,
0.018603235,
-0.013329611,
0.02596871,
-0.004928368,
0.0017482844,
-0.010770651,
0.0045695724,
-0.008414783,
-0.00795444,
0.020011341,
-0.0020749243,
0.013336381,
0.0072639273,
0.023937788,
-0.0026283502,
0.006658036,
-0.016788946,
0.021649618,
0.023626382,
0.023071263,
0.009883815,
0.019320829,
0.009464092,
0.0004954601,
0.015204828,
0.015448539,
0.034525655,
-0.0028297498,
-0.0067426576,
0.032521814,
0.00796798,
0.016788946,
0.014812184,
0.016640013,
-0.0050502233,
0.022191197,
-0.014798644,
-0.025318814,
-0.031005394,
-0.0101681445,
-0.012889579,
-0.046467472,
-0.018142894,
0.0018769095,
0.018440763,
0.02083725,
-0.0052397763,
0.010513401,
-0.013200986,
0.008360624,
-0.027647605,
0.0074873287,
-0.010059829,
0.010235841,
0.014595552,
0.034309026,
0.009484401,
-0.0062010786,
0.0077987364,
0.0006295855,
0.030138867,
-0.015556855,
0.03414655,
-0.0021933946,
0.009680724,
0.008841276,
-0.018968802,
-0.0051077665,
-0.000044399952,
-0.01590888,
0.028730761,
0.013519164,
-0.02106742,
0.07013447,
-0.006610648,
-0.013756105,
-0.0120772105,
0.004271704,
0.0025352663,
0.001426722,
0.007020217,
0.010811269,
-0.011109138,
0.0014444926,
-0.014460158,
0.0051043816,
-0.047794342,
-0.030734604,
0.016003657,
-0.00048192064,
0.018643854,
-0.008814197,
0.008550177,
0.011914737,
-0.021202816,
-0.0064583286,
0.01926667,
-0.025725,
0.0156110125,
0.012503703,
-0.027309118,
-0.011786112,
-0.021893328,
-0.014961118,
0.014920499,
-0.053887103,
-0.009098526,
0.02470954,
-0.013647789,
-0.011989203,
0.0024844934,
0.0067494274,
-0.0060250657,
-0.00565273,
0.028135026,
-0.014514315,
-0.0022204737,
-0.022692157,
-0.03265721,
0.001399643,
-0.013708716,
-0.004051687
] |
Studies with mice lacking the common plasma membrane receptor for type I interferon (IFN-αβR(-)(/)(-)) have revealed that IFN signaling restricts tropism, dissemination, and lethality after infection with West Nile virus (WNV) or several other pathogenic viruses. However, the specific functions of individual IFN subtypes remain uncertain. Here, using IFN-β(-)(/)(-) mice, we defined the antiviral and immunomodulatory function of this IFN subtype in restricting viral infection. IFN-β(-)(/)(-) mice were more vulnerable to WNV infection than | [
-0.023951419,
-0.013628695,
-0.015571795,
-0.0218329,
-0.00924997,
0.012279319,
-0.024018887,
0.009519846,
-0.019984255,
-0.019660404,
0.005731473,
-0.013817607,
0.0004090295,
0.011982457,
0.009405149,
-0.0013046777,
0.019107161,
-0.010545371,
0.011766557,
0.0059170127,
-0.025057906,
0.017757785,
0.00445294,
-0.026596196,
-0.018621385,
0.012711119,
0.0067165177,
-0.04506915,
-0.032277066,
-0.007124704,
0.023398176,
-0.0076442133,
-0.008406611,
0.021495555,
0.009675024,
-0.023155287,
0.0051107607,
-0.010444168,
0.021522542,
0.00847408,
0.016192509,
0.021063754,
-0.0026515233,
0.019417517,
0.0024575505,
-0.0031086244,
0.011739569,
0.005849544,
-0.009216236,
0.0006299898,
0.009830202,
-0.015355895,
-0.012920273,
0.0016723826,
-0.034220167,
0.01982233,
0.015342402,
-0.01960643,
-0.012022938,
-0.032088153,
-0.01705611,
0.009175755,
-0.021994824,
0.0073743383,
0.0077858977,
0.023209263,
-0.0068750693,
0.00987743,
-0.024126837,
0.019093666,
0.03257393,
0.020753399,
-0.028201953,
0.007873608,
0.008413358,
-0.0014480489,
-0.012130888,
0.016786234,
-0.01791971,
-0.0058832783,
0.027162934,
-0.016367927,
-0.016718766,
0.030927692,
0.026420776,
-0.005245698,
0.027351845,
0.011085122,
0.002153941,
-0.011543909,
0.017325984,
-0.0003445125,
0.016367927,
0.029281452,
0.012508713,
0.011469694,
-0.016610814,
0.009789721,
0.006419655,
0.015234452,
-0.006122792,
0.012960753,
-0.014978071,
-0.011510175,
-0.022736982,
-0.0025722475,
0.00077968615,
-0.0022011693,
0.048793428,
-0.016489372,
-0.032331042,
0.01943101,
-0.0057854485,
-0.049845938,
0.02047003,
0.016219497,
0.02025413,
0.002418756,
-0.01824356,
0.0012810635,
0.024302257,
0.0229124,
0.011429212,
-0.010336218,
0.03216912,
0.0242078,
-0.004223546,
-0.012353535,
-0.03203418,
-0.022291686,
0.02535477,
0.018270547,
0.028067015,
-0.004800404,
-0.0022112895,
0.019889798,
-0.04018441,
-0.006622061,
-0.014384345,
-0.01061284,
0.020024735,
0.039293822,
-0.016907677,
0.00050559425,
-0.006331946,
0.011813784,
0.04018441,
-0.011017653,
0.011334756,
0.0013620261,
-0.020389067,
-0.038942985,
0.026812095,
-0.032061167,
-0.004253907,
0.022318674,
-0.015342402,
0.037377708,
0.003105251,
-0.011186325,
0.004624985,
-0.011962215,
0.0069897664,
0.026177889,
0.020807374,
0.008777689,
-0.008555042,
0.0051579885,
0.0073810853,
0.0003651748,
0.006433149,
0.018580904,
-0.025395252,
0.016300458,
-0.0005047509,
0.02198133,
0.007441807,
0.016462384,
0.0110244,
-0.017541884,
-0.011861012,
0.010754525,
0.012657144,
-0.0036972894,
-0.0209693,
0.00946587,
0.030441916,
-0.021994824,
0.019377036,
-0.008008545,
-0.00987743,
0.014816145,
-0.011753063,
-0.014370851,
-0.63863254,
-0.022939388,
0.01921511,
0.011031146,
0.003585966,
0.016678285,
0.008730461,
-0.020429548,
-0.003916563,
0.037323732,
-0.009546833,
-0.014991565,
0.020699423,
-0.035083767,
-0.03162937,
-0.021994824,
-0.018324522,
0.00009071389,
0.001549252,
-0.010464408,
-0.021158211,
0.007563251,
-0.0027965812,
0.025341276,
0.0033346447,
0.0033363316,
0.024963452,
-0.025543682,
-0.019916786,
0.029902166,
-0.004193185,
0.042829186,
-0.00024204428,
-0.004591251,
0.052598666,
0.0021927354,
0.0016833462,
0.024099851,
0.027986053,
0.025422238,
-0.035542555,
-0.0024052623,
0.011732822,
0.007934329,
-0.010538625,
0.009486111,
-0.012130888,
0.017676823,
0.020645449,
-0.007124704,
0.021279655,
0.021778924,
-0.023141794,
0.024504663,
0.015328908,
-0.0004195715,
0.01889126,
-0.019377036,
0.023762507,
0.0021556278,
-0.007441807,
0.0010179353,
-0.015612277,
-0.03203418,
-0.009432136,
0.01091645,
-0.00212358,
-0.004520409,
0.018864272,
-0.0131901475,
0.03203418,
0.032277066,
0.0070235007,
0.010518384,
0.013750139,
0.035434607,
0.016003596,
-0.0043483633,
-0.011989203,
0.004935342,
-0.00095384,
-0.002159001,
-0.017865734,
0.008028786,
0.017406946,
-0.012387269,
-0.004398965,
0.029065553,
0.007556504,
0.012171369,
0.012313054,
0.009128527,
-0.0047902837,
-0.014127964,
-0.025017425,
0.028822666,
-0.0014657594,
0.0004385471,
-0.013109185,
0.006756999,
-0.015234452,
-0.0006531822,
0.000115645715,
-0.04417856,
0.00689531,
-0.0068818163,
-0.01899921,
-0.002912965,
0.0486315,
-0.010086584,
-0.0019144268,
-0.013115932,
0.016381422,
-0.00045667935,
0.03303272,
-0.021468569,
0.004544023,
-0.0030040478,
-0.0031541658,
-0.019538961,
0.0062644766,
-0.015882153,
0.004361857,
0.0019043065,
0.01126054,
-0.0013417855,
0.006035083,
-0.018648373,
-0.03300573,
-0.009088046,
0.02330372,
0.006281344,
0.009411896,
-0.0032334416,
0.015409871,
0.0110513875,
0.023708532,
0.006756999,
-0.012677385,
-0.03289778,
-0.029497353,
-0.023168782,
-0.017514898,
-0.0007855897,
-0.012582929,
-0.0004143005,
0.0041425833,
0.009890924,
0.016246485,
-0.014694702,
0.0004748116,
-0.0026194756,
0.0009605868,
0.008980095,
0.028552791,
-0.010795006,
0.01229956,
-0.018189585,
0.0029450124,
0.01325087,
-0.0038592145,
0.0031356118,
0.014020014,
0.015936127,
0.001968402,
-0.015463846,
0.028633753,
0.00350163,
0.014681208,
-0.043773748,
0.0044866744,
0.010619587,
-0.017676823,
0.009675024,
0.012980995,
0.012879792,
-0.00061565265,
0.00029201334,
-0.032654893,
0.008008545,
0.0006595074,
-0.016030584,
0.0013696164,
-0.004844259,
0.041209936,
0.0078263795,
0.026771614,
0.0073608444,
0.025692115,
0.036541093,
0.0070909695,
-0.0038490943,
-0.013426288,
0.01885078,
-0.0015382883,
-0.029605303,
0.029875178,
0.00946587,
-0.014559764,
0.022885412,
0.015355895,
-0.011921735,
-0.001973462,
-0.024369726,
0.012164623,
-0.029065553,
0.010059596,
-0.02233217,
0.012650398,
0.012609916,
-0.0074890354,
0.002160688,
-0.0065984474,
0.005144495,
0.014978071,
0.009789721,
-0.018796803,
0.009924659,
-0.00089733483,
-0.031008653,
-0.035758458,
0.0072596413,
0.0005422804,
-0.003754638,
-0.014829639,
0.0028775437,
0.004517035,
0.014411333,
-0.000087235036,
-0.01677274,
0.0008092038,
-0.0036298207,
0.009142021,
0.0034881362,
0.0031558524,
0.015396377,
-0.0050871465,
-0.014721689,
0.024234788,
-0.0033481384,
-0.007347351,
-0.007057235,
0.0062543564,
0.015558302,
0.009391655,
-0.0235601,
0.015396377,
0.0053334073,
-0.014087482,
0.029146515,
-0.01569324,
0.0030833236,
-0.005019678,
0.009344427,
0.004618238,
-0.0068312148,
0.016165521,
-0.00966153,
0.060398057,
0.027149439,
0.025300795,
-0.032978743,
0.0038558412,
-0.015032046,
0.017231528,
-0.00053975027,
-0.0061868876,
-0.006396041,
-0.0011107048,
0.017892722,
-0.028633753,
-0.004783537,
0.029578315,
0.009391655,
0.012717866,
-0.0017879228,
-0.001954908,
0.00021020744,
0.022615537,
-0.0028876641,
-0.006851455,
-0.029686267,
0.017177554,
-0.0021573144,
-0.01126054,
-0.0220488,
-0.016206002,
0.006956032,
-0.004547396,
-0.0022669511,
0.0058933985,
0.0036028333,
0.011125603,
0.009351173,
-0.0023361067,
-0.0012574495,
0.024936464,
-0.007279882,
-0.0025891147,
-0.0014193746,
0.009492858,
0.012184863,
-0.026083432,
0.0033869331,
0.0096952645,
0.013810861,
0.019957267,
-0.023384681,
-0.017676823,
0.001146126,
0.010174293,
-0.019228604,
-0.0021202066,
-0.024531651,
0.00890588,
0.008183964,
-0.010160799,
0.008784436,
0.024558637,
-0.0025536935,
-0.033194643,
-0.02822894,
-0.00076155394,
-0.01791971,
0.01802766,
0.0094388835,
0.00079571,
0.03192623,
0.023546606,
-0.0093241865,
-0.032654893,
-0.02029461,
0.020955805,
-0.036945906,
-0.0023293598,
-0.012886538,
0.0067165177,
0.011914988,
0.024194308,
0.009317439,
-0.007333857,
-0.021387605,
0.0000056267913,
-0.009169008,
0.026029458,
-0.018621385,
0.013642188,
0.029902166,
0.023101313,
0.0028016414,
-0.00062029116,
0.012825816,
-0.0061396593,
-0.027095465,
-0.0064803767,
-0.010511637,
0.003164286,
0.010302484,
-0.00017721098,
-0.033761382,
-0.0120499255,
0.018769816,
0.0074080727,
0.009742493,
0.023168782,
0.024558637,
0.004169571,
0.002718992,
-0.018014167,
-0.0116721,
-0.008946361,
-0.011658606,
-0.010734284,
-0.012980995,
0.031224554,
-0.016462384,
0.007731923,
-0.032600917,
-0.0014691328,
0.012954007,
0.000060985458,
0.02150905,
-0.00029538677,
-0.021414593,
-0.022534575,
-0.02470707,
0.022453612,
0.002261891,
-0.02704149,
-0.012697626,
-0.001368773,
0.0027628469,
-0.01072079,
-0.019781848,
0.04285617,
-0.021306643,
-0.018904753,
0.0027695936,
0.018688854,
0.026326321,
0.01893174,
-0.010295737,
0.0104374215,
0.02176543,
-0.01601709,
-0.014424827,
-0.0072663883,
-0.023708532,
0.018149104,
-0.000007129026,
0.0009648036,
-0.022575056,
-0.023695039,
-0.01677274,
-0.005731473,
0.012562688,
0.018081635,
0.0007982401,
0.001476723,
0.0129337665,
0.011125603,
0.03235803,
-0.018054647,
-0.012414257,
0.0000685757,
-0.0143033825,
-0.006058697,
-0.013844595,
-0.034597993,
-0.02779714,
0.0056909923,
0.011503428,
-0.027959066,
-0.0012228717,
0.0072528943,
-0.011348249,
0.028984591,
0.004169571,
0.030091079,
0.023708532,
0.0077858977,
0.016529853,
0.021144718,
-0.028525803,
-0.020321598,
-0.010606093,
0.0022416504,
0.009708758,
-0.019673899,
0.016718766,
-0.0044967947,
-0.026555715,
-0.01960643,
-0.01411447,
-0.014060495,
0.019808836,
0.013756885,
-0.017582366,
-0.034490045,
-0.0028826038,
-0.013716404,
0.011267288,
0.0050938935,
-0.013621948,
-0.0069627785,
0.012130888,
0.007131451,
-0.019849317,
0.01623299,
-0.034678955,
0.0045743836,
0.019930279,
0.004017766,
0.006048577,
-0.0020915323,
-0.017015629,
-0.0040413802,
-0.019012704,
-0.028067015,
-0.05197795,
-0.009101539,
-0.010781512,
0.02822894,
0.026245357,
0.00056800287,
-0.010214774,
0.009020576,
0.013885076,
0.005451478,
0.015396377,
0.0064702565,
0.019484986,
-0.024801526,
0.022750475,
0.021616999,
-0.011591137,
0.015409871,
-0.0049758228,
0.03451703,
-0.010390193,
-0.020699423,
-0.016044077,
-0.003916563,
-0.009492858,
-0.012218597,
0.017852241,
-0.011840772,
0.0033262111,
-0.033275604,
-0.014451814,
0.006035083,
-0.016300458,
-0.0036433144,
0.006763746,
0.0033194644,
-0.009998874,
0.012400763,
-0.009594061,
0.021805912,
-0.0048948606,
0.012326547,
0.002557067,
0.002105026,
0.021252668,
0.0048341383,
0.00043728208,
0.0028944109,
-0.012616663,
0.01465422,
0.0065883268,
-0.010228268,
-0.004554143,
-0.008291914,
-0.027716177,
-0.013318338,
-0.028579777,
-0.011753063,
-0.021306643,
-0.011004159,
0.0063859206,
-0.010673562,
-0.0027982679,
-0.02768919,
-0.029794216,
0.014681208,
-0.024464183,
0.033815354,
-0.022777462,
0.022939388,
0.033923306,
-0.0038963223,
-0.036109295,
-0.025300795,
-0.008298661,
0.006197008,
0.040103447,
0.022102775,
0.0036972894,
-0.028525803,
0.009182502,
0.01165186,
0.0041898116,
-0.04701225,
0.030441916,
0.0042741476,
0.0028893508,
-0.014289889,
-0.011894747,
-0.020753399,
0.03343753,
-0.02233217,
0.0024389967,
-0.0005380636,
-0.00077799946,
-0.0008981782,
0.010707296,
0.009378161,
0.014789158,
-0.00034704257,
0.00004875674,
0.009040818,
-0.041722696,
0.0018975596,
-0.011328009,
0.010761271,
0.03519172,
-0.0020864722,
-0.007171932,
0.010875968,
0.023398176,
-0.010315977,
-0.0033059705,
-0.019471493,
0.038133357,
-0.0078398725,
-0.012421004,
0.007995051,
0.007549757,
0.0068750693,
0.0054042498,
-0.005589789,
-0.019269085,
-0.005107387,
-0.009924659,
0.039239846,
0.013885076,
-0.016327446,
0.011699088,
-0.027878102,
0.0064837504,
-0.033275604,
-0.03017204,
-0.00050306413,
-0.03386933,
0.011928481,
-0.006237489,
-0.01644889,
0.018837284,
0.017771278,
0.0130484635,
0.014829639,
0.02779714,
-0.016394915,
-0.0019380408,
-0.0020206901,
0.0153019205,
-0.037809506,
-0.006433149,
-0.01666479,
-0.0488474,
0.0063690534,
-0.012232091,
-0.01928258,
-0.026744626,
0.009573821,
0.020564485,
0.013939051,
-0.02600247,
0.041830648,
0.0014632293,
0.017514898,
-0.010498143,
-0.013635442,
0.03786348,
-0.016475877,
0.0042572804,
0.0100798365,
0.0064230287,
0.0067941067,
0.008662992,
-0.0027223655,
-0.0074957823,
-0.017015629,
-0.032951754,
-0.02930844,
-0.004206679,
-0.0004705948,
-0.012940513,
-0.004392218,
-0.02018666,
-0.013554479,
-0.011321262,
0.013635442,
-0.0042269193,
-0.010160799,
-0.005906892,
0.0030479024,
0.017164059,
-0.013831101,
-0.026798602,
0.0094388835,
-0.03497582,
-0.010774765,
-0.0066861566,
-0.017245023,
0.032978743,
-0.0010466096,
0.02481502,
-0.0037512644,
0.001136849,
-0.028849654,
-0.004601371,
-0.005731473,
0.02844484,
-0.002315866,
0.016826715,
-0.0023917684,
0.0034071738,
-0.015234452,
0.001966715,
-0.004891487,
-0.010471156,
0.0083256485,
-0.003639941,
0.02366805,
0.019876305,
-0.012144381,
-0.016637802,
0.0419386,
-0.03041493,
-0.018081635,
0.02866074,
-0.035245694,
0.008642752,
-0.015369389,
0.020281117,
0.006348813,
-0.0033380182,
0.0025520069,
0.0025014053,
-0.0068683224,
0.0056403903,
-0.00605195,
-0.015747216,
-0.0068818163,
0.015666252,
0.009067805,
0.004621612,
-0.0065680863,
-0.03886202,
0.007995051,
-0.002250084,
0.0036331941,
0.021873381,
0.0068076006,
-0.008703473,
-0.002304059,
0.00089986494,
0.0034088604,
0.0021218932,
0.011496681,
0.018149104,
0.0000039631323,
0.008865398,
-0.01975486,
0.0028657366,
0.020092204,
-0.022129761,
0.007225907,
-0.011172831,
0.011820531,
-0.02014618,
-0.0009335993,
-0.009708758,
-0.0001113235,
-0.006655796,
-0.0083256485,
0.02144158,
-0.021886874,
0.004122343,
-0.013352073,
0.0041560773,
-0.01573372,
0.020699423,
0.011429212,
-0.006517485,
-0.00881817,
-0.015369389,
-0.01307545,
-0.0047565494,
0.20424151,
-0.015558302,
0.015180477,
0.010430674,
-0.010228268,
0.011982457,
0.010133811,
-0.012070166,
0.03095468,
-0.024045875,
0.017150566,
0.000117859534,
-0.006237489,
0.00371753,
0.0033194644,
-0.007225907,
-0.010821993,
-0.01677274,
-0.040157422,
0.008507814,
0.011206565,
-0.0053097936,
0.026474752,
-0.00254526,
0.051168326,
0.015355895,
-0.028714715,
0.026245357,
0.006949285,
0.010788259,
-0.02963229,
0.0019481612,
-0.0018520182,
0.014600245,
0.009310693,
-0.0018604518,
-0.030657817,
-0.002400202,
0.012333294,
-0.00035842793,
-0.016192509,
0.014141457,
-0.0076509602,
-0.0015829864,
0.008595523,
0.0150455395,
0.006956032,
-0.017258516,
-0.0014033507,
0.0110513875,
-0.041749686,
0.010727537,
0.00001211012,
0.011678847,
-0.011611378,
-0.011408972,
0.011354997,
0.0017778025,
-0.001739008,
0.024680082,
-0.026623184,
-0.009796468,
-0.019390529,
0.041021023,
-0.016435396,
0.057915207,
-0.014681208,
-0.00393343,
0.0069965133,
-0.015005058,
-0.002465984,
-0.012090406,
-0.04083211,
0.008609017,
-0.016745754,
-0.00593388,
0.012528953,
0.044070613,
0.025773076,
0.0023192395,
0.000350416,
-0.0055628014,
-0.031899244,
0.006210502,
-0.012313054,
-0.034921844,
0.030738778,
-0.013298098,
-0.00924997,
0.011570897,
0.0055020796,
0.0059709875,
-0.025705608,
-0.0048712464,
0.010714043,
-0.017879229,
-0.014681208,
-0.024288762,
0.0038659615,
-0.014154951,
-0.00890588,
0.08657595,
0.012454738,
-0.003422354,
-0.0068615754,
0.012501966,
0.01242775,
0.00054312375,
-0.0032165744,
-0.005336781,
0.0074822884,
-0.021279655,
0.008244686,
-0.01422242,
0.009418642,
0.017784772,
0.013385807,
-0.01465422,
0.01889126,
0.016354434,
0.0069695255,
-0.021643987,
-0.0020594846,
0.019350048,
-0.0068548284,
0.0062611033,
-0.024882488,
0.019147642,
-0.0030479024,
-0.01644889,
-0.014087482,
-0.0056032827,
-0.0034307877,
-0.0011798604,
0.012852804,
-0.010889462,
0.030684805,
-0.0113077685,
-0.008541549,
0.0010272122,
0.0006826998,
-0.024194308,
0.027743164,
-0.00890588,
-0.0053806356,
-0.0033886197,
0.020915324,
0.035353646,
-0.0021758683,
0.0010019115,
-0.0061700204,
-0.049845938,
-0.013102438,
-0.0081974575,
0.016475877,
-0.011186325,
-0.01307545,
-0.033464517,
-0.010943437,
0.0076779476,
-0.013115932,
0.0040278863,
0.009809962,
-0.027014501,
-0.011624872,
0.0015981669,
-0.17110084,
0.0085820295,
0.001666479,
0.0025823677,
0.044124585,
-0.0050095576,
-0.0056403903,
-0.03270887,
-0.01208366,
0.0125491945,
0.027216908,
-0.008595523,
-0.029254466,
0.008156977,
-0.002153941,
-0.008885639,
-0.018769816,
0.03332958,
0.0012194983,
0.014127964,
0.047956813,
-0.03052288,
-0.0014421453,
-0.021643987,
0.00063758006,
0.027959066,
-0.014978071,
-0.022183737,
0.006730011,
-0.032816816,
0.0155448085,
0.006544472,
0.03538063,
-0.023816481,
0.035650507,
-0.0075902385,
0.0004807151,
-0.014721689,
-0.008723714,
0.03311368,
0.043584835,
0.021036768,
-0.0006654109,
0.0040413802,
-0.014964577,
0.0018790057,
0.0072663883,
0.0052490714,
0.0021674347,
-0.019147642,
-0.0038862021,
-0.020807374,
0.009911165,
0.003778252,
0.02546272,
0.0069222976,
-0.0010735971,
-0.00017858144,
-0.004091982,
-0.007232654,
-0.038592145,
-0.015909139,
0.03573147,
0.0000120771765,
0.014856626,
-0.017649835,
-0.013831101,
0.01694816,
-0.013770379,
0.0032435618,
-0.033842344,
-0.010768019,
0.02029461,
-0.016098052,
0.026920045,
0.020604968,
-0.010342965,
0.01878331,
-0.0068683224,
0.014262902,
-0.0074687945,
0.018095128,
-0.0048948606,
-0.0077926447,
0.004102102,
0.015220958,
0.018297534,
0.0124344975,
0.01573372,
0.010646574,
0.006929044,
-0.019930279,
0.0033599455,
-0.031818278,
0.01889126,
0.025152363,
0.019970762,
-0.017352972,
0.00010953136,
0.0009825142,
0.027392328,
-0.03386933,
-0.013520745,
0.0044563133,
0.008980095,
-0.019053185,
-0.01677274,
0.02384347,
0.038511183,
-0.01091645,
-0.0073810853,
0.011914988,
0.005940627,
0.012704372,
-0.008986842,
-0.004044754,
-0.00721916,
-0.008723714,
-0.0024204426,
-0.0451771,
0.06374451,
0.015976608,
0.02036208,
-0.0076914416,
-0.013993027,
-0.019107161,
-0.13536938,
-0.041290898,
0.0056741247,
-0.0016909365,
-0.026231864,
0.03257393,
0.007333857,
0.021320136,
-0.007131451,
-0.0014994937,
-0.033383556,
0.009128527,
-0.010761271,
-0.02090183,
-0.005819183,
0.0015812997,
0.020928817,
-0.017272009,
-0.011287528,
0.05049364,
0.008480826,
-0.025557177,
-0.0025975483,
0.0076509602,
0.016583828,
-0.012198357,
-0.00946587,
0.0037647584,
0.0043820976,
0.015220958,
0.0027763406,
0.0015568422,
0.017906215,
0.005637017,
-0.029686267,
-0.009263464,
-0.01389857,
-0.010302484,
0.018958729,
-0.0013907003,
0.010491396,
0.0007366748,
-0.005589789,
0.0011731135,
-0.010012368,
-0.002611042,
-0.015625771,
-0.013365567,
0.01813561,
-0.0075969854,
-0.02057798,
-0.013912064,
-0.042829186,
-0.021522542,
0.021482062,
0.0011807038,
-0.0058731576,
0.036109295,
-0.01627347,
0.01928258,
0.0065714596,
-0.0002342432,
-0.019700885,
0.018338015,
0.0039772848,
-0.02459912,
-0.0057483404,
-0.01885078,
0.028390866,
-0.04266726,
0.006703024,
-0.011739569,
0.0044495664,
-0.011766557,
-0.0028623634,
0.003471269,
-0.0047194418,
0.0047936575,
-0.003808613,
-0.017757785,
-0.022102775,
-0.0075834915,
0.019795341,
-0.0070235007,
0.029254466,
0.014829639,
-0.00026017652,
0.017568871,
0.010140559,
0.015855165,
-0.007610479,
0.04442145,
0.004544023,
-0.01601709,
-0.015571795,
0.0048510055,
0.0023563474,
-0.008231192,
0.016961653,
0.038754072,
-0.028417854,
0.0037951192,
-0.053678166,
0.014397839,
-0.015139996,
-0.009432136,
0.0081974575,
0.0015981669,
-0.002899471,
-0.0054683452,
0.00005481839,
-0.0023310466,
-0.025624646,
0.005252445,
-0.030927692,
0.011888,
-0.01802766,
-0.011328009,
0.02801304,
-0.02639379,
0.010120318,
0.034894858,
0.0040278863,
-0.0008146856,
0.008548295,
0.0027527264,
-0.015166983,
-0.01824356,
-0.015814684,
0.015423365,
-0.013696164,
-0.0028960977,
-0.006173394,
-0.012609916,
-0.011888,
0.016813222,
-0.0026970648,
-0.012447991,
0.003429101,
0.032951754,
0.008177217,
0.036433145,
-0.019781848,
-0.03389632,
0.007556504,
-0.017784772,
0.008224445,
-0.0015661191,
-0.039995495,
0.011179578,
-0.009162261,
-0.022858424,
0.017555378,
0.006726638,
-0.032924768,
-0.024018887,
-0.010680309,
0.00942539,
0.013392554,
-0.01796019,
-0.010862474,
-0.008831664,
0.0115641495,
0.02208928,
0.0076846946,
0.0024389967,
0.014033508,
-0.030549867,
-0.033059705,
0.012090406,
-0.0008661305,
-0.0007236027,
-0.022561561,
0.021724949,
0.010315977,
-0.022291686,
0.010511637,
0.012792082,
-0.012980995,
0.00051487115,
-0.008804677,
0.025827052,
0.025422238,
-0.0061025517,
-0.04037332,
-0.0025789943,
0.01433037,
0.010707296,
-0.007448554,
0.00092432235,
0.0039975257,
-0.0024744177,
0.0074215666,
0.011638366,
0.0050095576,
0.0068548284,
0.0037107833,
0.021252668,
0.0153019205,
0.009398402,
-0.003525244,
0.044610362,
-0.001711177,
0.0025705607,
0.01899921,
-0.012029684,
0.0013392554,
0.026204877,
-0.034867868,
-0.04525806,
-0.011004159,
-0.010639828,
-0.0018098502,
0.00721916,
-0.0018992464,
-0.0052187108,
-0.016813222,
0.0020122565,
0.006780613,
0.00078390294,
-0.014370851,
0.024585625,
0.0037209035,
0.01677274,
-0.012016191,
-0.022790955,
-0.017582366,
-0.004638479,
0.044691324,
-0.04115596,
0.011631619,
-0.009270212,
-0.00007679845,
-0.0010449229,
-0.025543682,
-0.0055965357,
-0.000043406675,
-0.002116833,
0.009128527,
0.005134375,
0.0026987514,
0.06844033,
0.019134147,
-0.0123198,
-0.016732259,
-0.043368936,
0.0089531075,
0.025840545,
0.006348813,
0.0064837504,
-0.030765766,
0.019039692,
-0.035434607,
0.013993027,
-0.023951419,
-0.03983357,
0.015922634,
-0.022790955,
0.008501067,
-0.012893285,
-0.0048476323,
0.02876869,
-0.0023057458,
0.029821204,
0.0066456753,
-0.04061621,
0.0010272122,
0.015517821,
-0.004409085,
-0.0009150454,
-0.011348249,
0.004712695,
-0.016907677,
-0.03527268,
-0.014735183,
0.0042572804,
-0.009142021,
0.0016884063,
-0.019930279,
0.012279319,
0.023897445,
-0.0051647355,
0.005242325,
-0.028606765,
-0.016961653,
0.039293822,
-0.003068143,
-0.03888901,
0.0041729445,
-0.006038456
] |
The activation of T cells is the fundamental on switch for the adaptive immune system. Ca2+ signaling is essential for T cell activation and starts as initial, short-lived, localized Ca2+ signals. The second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) forms rapidly upon T cell activation and stimulates early Ca2+ signaling. We developed a high-resolution imaging technique using multiple fluorescent Ca2+ indicator dyes to characterize these early signaling events and investigate the channels involved in NAADP-dependent Ca2+ signals. In the first seconds of activation of either primary murine T cells or human Jurkat cells with | [
-0.019432604,
-0.009523703,
0.0054525523,
-0.030709624,
-0.00475521,
0.013760887,
-0.025077756,
-0.0050972397,
-0.008573989,
-0.009782716,
0.021318749,
0.015992383,
-0.0124658225,
0.012392768,
-0.0067376546,
-0.007298849,
0.029195396,
0.007557862,
-0.014996179,
0.0122068105,
-0.034083433,
0.022912674,
0.0010194479,
-0.026631832,
0.007677406,
0.00352988,
0.008846285,
-0.04279689,
-0.030815886,
-0.017626155,
-0.001657018,
-0.0077903094,
-0.018104333,
-0.010573037,
0.013760887,
0.0046821553,
0.0054293075,
-0.022527475,
0.027654601,
-0.0034601458,
0.0051105227,
0.00416745,
0.0012560462,
-0.016258037,
-0.003984813,
-0.008925981,
-0.00401802,
-0.0001896937,
-0.022686869,
0.03490696,
0.007889929,
-0.0057480927,
-0.007982909,
0.0031994728,
-0.018688772,
-0.031400327,
0.0056783585,
0.019007558,
0.006402266,
-0.041734274,
-0.029407918,
0.00040263214,
-0.010513265,
0.02794682,
0.004260429,
0.006010426,
0.027867125,
0.035464834,
0.00056742074,
0.010367155,
0.018648924,
0.038546424,
-0.015726728,
-0.009563551,
0.02823904,
0.006209667,
-0.030789321,
-0.0047518895,
-0.019910783,
0.024466751,
0.022394648,
-0.029275091,
-0.019884216,
0.0348007,
-0.0015192099,
0.00054376095,
-0.0012626876,
0.008082529,
-0.0011472941,
-0.0090720905,
0.019645128,
0.03068306,
0.031054975,
0.035597663,
-0.006657958,
0.006584903,
0.010320665,
0.026751377,
-0.016377581,
-0.025263714,
-0.004207298,
-0.01245254,
-0.002307871,
-0.019645128,
-0.017201109,
-0.0075910687,
-0.011688785,
-0.0023128518,
0.007929778,
-0.0003465957,
-0.034189694,
0.038360465,
-0.020455373,
-0.031054975,
0.016709648,
0.02514417,
0.009576834,
0.0063358527,
-0.0033190171,
-0.017240956,
0.0074781654,
0.00803604,
0.012970566,
-0.011828253,
0.026552137,
0.03299425,
0.005641831,
-0.012910794,
-0.014650829,
-0.009271331,
-0.006106726,
0.012392768,
-0.00054915703,
0.036368057,
-0.006508528,
-0.007524655,
0.004426463,
0.0043135597,
-0.0048315856,
-0.023125198,
0.0010402022,
0.0361821,
-0.0017068281,
-0.017240956,
0.014053106,
0.023736201,
0.019419322,
0.00013728926,
-0.0009098656,
0.019671693,
-0.004622383,
-0.01995063,
0.0064155487,
-0.015275116,
-0.0014934747,
0.029328223,
-0.016151775,
0.034295958,
0.0030367596,
-0.01916695,
0.004406539,
-0.0050208643,
-0.011795046,
-0.002515413,
0.027149858,
0.020309264,
0.017068282,
0.004506159,
0.003328979,
-0.029089134,
0.0017383746,
0.014092955,
0.010612885,
0.018197313,
-0.023151763,
0.010028446,
-0.0041442052,
0.01676278,
-0.007850082,
-0.024280794,
0.004971054,
-0.00436337,
0.011243814,
-0.0061100465,
-0.014438305,
-0.005542211,
0.023696354,
-0.012784608,
-0.007956343,
-0.022965806,
0.0015075875,
0.0019359549,
-0.013269427,
-0.008819719,
-0.64054537,
-0.00081730174,
0.021451576,
-0.0029471011,
-0.0095170615,
0.03862612,
0.010221045,
-0.0072257943,
0.008554065,
0.025276996,
-0.02162425,
0.004343446,
0.0017151298,
-0.025436388,
-0.03392404,
-0.024533164,
-0.009178353,
-0.007823516,
0.027601471,
-0.0012469144,
-0.014610981,
-0.006269439,
0.0011057856,
0.031214368,
-0.0012784608,
0.006797427,
-0.0047386065,
-0.009616681,
-0.016231472,
0.0475521,
-0.011057856,
-0.004419822,
0.016922172,
-0.018316856,
0.04210619,
-0.010400361,
-0.007856723,
0.037377544,
-0.0029720063,
0.02392216,
-0.019445887,
-0.007112891,
0.008221997,
0.0048216237,
-0.033073947,
0.010340589,
-0.026153656,
0.007411752,
0.014597698,
-0.01485007,
0.037590068,
-0.009457289,
-0.04053883,
-0.0025071115,
0.031240933,
-0.0047585308,
0.011190683,
-0.015793141,
0.014172651,
0.01210719,
-0.014518002,
0.018502815,
-0.013010414,
-0.032383244,
-0.012332995,
0.007770385,
-0.020561634,
0.0038054963,
-0.005661755,
0.024187814,
0.011549316,
0.0016296224,
0.004303598,
0.00048232838,
0.007471524,
0.008354824,
-0.012505671,
0.010513265,
-0.011828253,
0.0085275,
-0.02018972,
0.007079684,
-0.035597663,
0.0015466055,
0.0014478153,
0.013043621,
-0.022182126,
0.017413633,
0.022314953,
0.011117628,
0.021836774,
-0.019844368,
-0.0072324355,
-0.03405687,
-0.026485723,
0.030709624,
-0.01426563,
-0.010938311,
-0.008560706,
-0.008454445,
0.000042234864,
0.008255204,
-0.01754646,
-0.0006105896,
0.029939227,
-0.02215556,
-0.04285002,
0.0065649794,
0.06843252,
-0.030284578,
0.0017516573,
-0.017161261,
0.002887329,
-0.0105863195,
0.016629953,
-0.01588612,
0.030815886,
0.024028422,
0.0057514133,
-0.008109095,
0.013933563,
-0.008925981,
-0.002387567,
-0.0166698,
0.019578714,
0.023297872,
-0.00023369267,
-0.020774158,
-0.009756151,
-0.009835847,
-0.008407955,
-0.0080028325,
0.008906057,
-0.0057414514,
-0.0025868076,
0.0010875219,
0.008979112,
0.01833014,
0.005774658,
-0.02151799,
-0.031798806,
-0.0055023623,
-0.007524655,
-0.021690665,
-0.02102653,
-0.028053083,
-0.019392757,
0.0109781595,
-0.0055953413,
-0.009238125,
0.000060706134,
-0.0041342434,
-0.023364287,
0.012565443,
0.016244754,
-0.0021750438,
-0.01107778,
0.00023950386,
0.021106226,
-0.020574918,
-0.0019691617,
0.01750661,
-0.016656518,
0.0065516965,
-0.02406827,
0.006003785,
0.010181197,
0.009344386,
0.016948737,
-0.045214344,
-0.0020604804,
-0.01519542,
-0.01411952,
0.022036016,
-0.015859555,
0.013800736,
-0.006926933,
-0.0034867113,
-0.004064509,
-0.0032625655,
-0.014889917,
-0.02029598,
-0.0005657604,
-0.023643224,
0.03230355,
-0.0021534592,
0.0038154584,
0.0062594768,
-0.012253299,
0.042026494,
-0.015314965,
-0.0006118348,
-0.034481913,
0.0070464774,
0.008786513,
-0.02975327,
0.010566396,
0.0010385419,
0.009331103,
0.011981004,
-0.006196384,
-0.0007724726,
0.03562423,
-0.000431273,
-0.0052732355,
0.00006309287,
0.0017915055,
-0.014531285,
0.037776027,
0.0020621407,
-0.0011746896,
0.016656518,
0.0110312905,
-0.008454445,
-0.0076840473,
0.028371867,
-0.0072324355,
0.0015175496,
0.015115724,
-0.020415524,
0.00406783,
-0.0031745676,
0.03015175,
-0.021531273,
-0.0071793045,
0.0144515885,
0.010420286,
0.028079648,
-0.011024649,
-0.00030820037,
-0.014053106,
-0.0121005485,
-0.016005665,
0.0051404084,
0.0066546374,
-0.005525607,
0.0024240946,
0.0073254146,
0.019299777,
0.014544567,
0.0026947297,
0.025675477,
-0.008514217,
-0.0048249443,
-0.00045659314,
-0.017825397,
0.015421226,
0.022288388,
-0.029354788,
0.02475897,
0.003559766,
0.001985765,
-0.009390876,
0.010778919,
0.00031255875,
-0.008494292,
0.03530544,
0.007524655,
0.05509668,
0.04157488,
0.0071793045,
0.004323522,
0.018954426,
-0.02122577,
-0.000019249552,
0.0124923885,
-0.00077786867,
-0.015394661,
-0.013455384,
-0.0117087085,
-0.016736215,
0.00032044537,
0.008374749,
-0.018980993,
-0.00012618574,
0.014172651,
0.008952546,
-0.008979112,
0.0106394505,
0.0019791238,
-0.0033206774,
-0.02328459,
0.029620443,
0.013123317,
-0.021332031,
-0.026259918,
-0.025954414,
-0.018077768,
-0.011788405,
-0.006774182,
-0.019445887,
0.015208703,
-0.0079762675,
0.0008559046,
-0.008673609,
-0.032462943,
0.023908878,
0.008301694,
0.028664088,
-0.008009474,
0.0061831013,
-0.009875694,
-0.024679275,
-0.007677406,
0.015514205,
0.0016354336,
0.0010202781,
-0.01132351,
-0.00021148565,
-0.024201097,
0.007830157,
0.00079571735,
-0.015328247,
-0.040804483,
0.0098026395,
-0.0028209155,
0.013096752,
0.0018595794,
0.047233317,
0.0073054903,
-0.020508504,
-0.017573025,
0.009523703,
-0.021332031,
0.03259577,
0.014385175,
-0.00070273835,
0.012638498,
-0.03113467,
-0.014863352,
-0.008753305,
0.0039051166,
0.035411704,
-0.011403206,
-0.026910769,
0.020747593,
0.014345326,
0.010240969,
0.020628048,
0.036368057,
-0.0039383234,
-0.010074935,
0.020163152,
-0.0076508406,
-0.0022813054,
0.0099089015,
0.040618528,
0.0205882,
0.018197313,
-0.012684988,
0.009370952,
0.027654601,
-0.0029188755,
-0.0184364,
0.021783644,
0.025675477,
-0.013488592,
-0.0043135597,
-0.0075180135,
-0.022819696,
-0.016284602,
0.052626096,
-0.0028325377,
0.0101944795,
0.031798806,
-0.004695438,
0.005910806,
-0.0044231424,
-0.005180257,
-0.0050175437,
0.017931659,
-0.00050183735,
0.008421238,
-0.007730537,
0.030895583,
-0.020721028,
-0.0075180135,
-0.014464871,
0.004283674,
0.004446387,
-0.015647031,
-0.015593901,
0.01426563,
0.011629012,
-0.028424999,
-0.006010426,
0.01945917,
-0.025476238,
-0.00055662857,
-0.010606243,
-0.01916695,
-0.013515157,
-0.01284438,
-0.0041010366,
-0.006946857,
-0.03966217,
-0.03647432,
0.005313084,
0.019844368,
0.0038918338,
0.022434497,
0.03148002,
-0.018888013,
0.03411,
-0.015394661,
-0.01887473,
-0.027840558,
-0.030815886,
0.018542662,
0.02147814,
0.028292172,
-0.026392745,
0.011277021,
-0.008892774,
0.0021368559,
-0.01352844,
-0.0010509944,
-0.0053994213,
-0.0036062556,
0.019007558,
0.025077756,
0.0045128004,
0.006349135,
-0.012279865,
-0.027229555,
-0.033897474,
-0.003499994,
-0.018316856,
-0.0083349,
-0.03456161,
0.005621907,
0.022620454,
-0.015314965,
-0.026724812,
-0.020203002,
-0.0131366,
0.011383282,
-0.016204907,
0.028982872,
0.02618022,
0.0039748508,
0.0070929667,
-0.009052167,
-0.017015152,
0.0026930694,
-0.0101944795,
0.028982872,
0.001877843,
-0.025024625,
0.014172651,
-0.0043932563,
-0.005744772,
0.0062362324,
-0.0026880885,
-0.006548376,
0.022660302,
-0.008952546,
-0.03108154,
-0.01113091,
0.009198276,
-0.0021351955,
-0.00392172,
0.0011497845,
-0.011416489,
-0.008507576,
0.014889917,
-0.0060071056,
0.0038851926,
0.0144250225,
-0.033127077,
-0.011051214,
0.0041309227,
0.013960128,
0.010207762,
-0.02073431,
-0.0105331885,
-0.031161238,
-0.016258037,
-0.0055554933,
-0.023536962,
0.010407003,
0.00060311804,
0.019007558,
0.034747567,
0.039794996,
-0.00015140214,
0.008494292,
0.016364299,
-0.011828253,
0.007544579,
0.0051536914,
0.010055011,
-0.011768481,
0.01053983,
0.020681178,
-0.007617634,
0.0151024405,
-0.013116675,
0.038121376,
0.0032957722,
-0.00050183735,
-0.033100512,
0.0005117994,
-0.02416125,
-0.016297884,
0.019870933,
-0.014305478,
-0.0014884936,
-0.0015524167,
-0.0077903094,
0.027920255,
0.021943036,
-0.0028557826,
-0.0018263726,
0.01690889,
-0.009815922,
0.012425975,
-0.009258049,
0.019392757,
-0.01044021,
-0.04274376,
-0.002417453,
0.013694474,
0.009782716,
0.0045725727,
0.001004505,
0.018688772,
0.00445967,
-0.012399409,
0.0053097634,
-0.022022732,
-0.014332044,
-0.035943013,
-0.012240017,
-0.027973386,
-0.009742867,
-0.019738106,
-0.032622334,
0.00990226,
0.007823516,
-0.01504931,
0.014743808,
-0.0044862353,
-0.010672657,
0.0368728,
-0.003343922,
0.019060688,
-0.03400374,
0.035703924,
-0.001578152,
0.01574001,
-0.014597698,
-0.018755186,
-0.0072523593,
0.020309264,
0.036022708,
0.024679275,
0.0018313536,
-0.00250047,
0.010227687,
0.015248551,
-0.009869053,
-0.022739999,
0.033791214,
-0.00071726635,
-0.00050183735,
-0.020375676,
0.0029155547,
0.0045028385,
0.005824468,
-0.008241922,
-0.010327307,
0.014518002,
-0.018768469,
-0.020056892,
0.02093355,
-0.012299789,
0.025569215,
-0.009676454,
-0.024838667,
0.016151775,
-0.012472465,
0.010015163,
-0.011270379,
-0.015075875,
0.012804532,
0.007810233,
0.0034435424,
0.018077768,
0.011695426,
0.016058795,
-0.0039383234,
0.011011366,
0.039449647,
0.002691409,
-0.009769433,
0.019618561,
0.02250091,
-0.0008575649,
-0.0094107995,
-0.013840583,
-0.009809281,
-0.053555883,
0.007292208,
0.014026541,
0.004210619,
-0.026020829,
0.014677394,
-0.012957283,
-0.0027146537,
-0.02858439,
0.005764696,
-0.0066679204,
-0.038944904,
-0.014717243,
0.008819719,
-0.007338697,
0.015288399,
0.006999988,
0.016165057,
-0.0022929278,
0.018861448,
-0.018423118,
0.025423106,
0.021305466,
0.035943013,
-0.007823516,
0.0073519796,
0.004200657,
-0.0067476165,
0.020867137,
-0.008866209,
-0.04338133,
-0.001857919,
-0.0039980956,
0.01574001,
0.022089146,
0.0030350992,
0.03299425,
0.020614766,
0.009815922,
0.017267523,
-0.0095170615,
0.0031181162,
-0.030656494,
-0.004775134,
0.024201097,
-0.0047817756,
-0.0010468436,
0.0074914484,
-0.009616681,
0.015806425,
-0.0021285543,
-0.038652685,
-0.037032194,
0.002666504,
-0.010453492,
-0.022341518,
0.004207298,
0.0021800247,
-0.02401514,
0.020322546,
0.001940936,
0.003705876,
-0.0055953413,
-0.022766564,
-0.0013548364,
0.017466763,
-0.01362806,
-0.0060071056,
0.008600554,
-0.022766564,
-0.04314224,
-0.007033195,
-0.04215932,
0.0012618575,
0.016988585,
-0.0040777917,
-0.018648924,
0.003201133,
-0.037616633,
-0.022819696,
-0.013216296,
-0.016258037,
0.016165057,
0.020481938,
-0.013800736,
-0.0046589104,
-0.022952523,
-0.0040943953,
0.00058859005,
-0.005997143,
0.015368095,
-0.015925968,
0.017333936,
0.010167914,
-0.03304738,
0.00480502,
0.036155537,
-0.03211759,
0.010028446,
0.009729585,
-0.02592785,
0.008580631,
0.010712505,
0.015407943,
0.0045260834,
0.016417429,
0.03809481,
-0.021703947,
0.00076334074,
0.018569227,
-0.014783656,
-0.023709636,
-0.015514205,
-0.014172651,
0.01681591,
0.001930974,
-0.00882636,
-0.02490508,
-0.0023610017,
-0.0055554933,
0.00025901283,
0.0348007,
-0.019831086,
0.00013438366,
0.021757077,
-0.0066546374,
-0.018423118,
0.0006155706,
-0.0348007,
-0.011137552,
0.0044729523,
-0.007617634,
-0.009616681,
-0.002573525,
0.0052400287,
-0.039263688,
0.004615742,
-0.0077969506,
0.007730537,
-0.03496009,
0.018662207,
0.016536973,
-0.023058783,
0.016377581,
-0.0037457242,
-0.010260893,
-0.009271331,
-0.014703959,
-0.00038063264,
-0.002769445,
-0.01750661,
0.008421238,
-0.008640403,
0.013601495,
-0.0029919303,
-0.0069136503,
-0.030470535,
-0.011536033,
0.18627672,
-0.021610968,
-0.005960616,
0.005024185,
0.0030384199,
0.011290303,
-0.008573989,
-0.0009032243,
0.0034003737,
-0.026910769,
0.015593901,
0.028292172,
-0.00759771,
-0.007969626,
-0.0003926701,
-0.0026083922,
-0.0071925875,
-0.0136413425,
-0.025210584,
0.0017134695,
0.020548351,
-0.0045493282,
-0.002209911,
0.0057348097,
0.033950604,
0.00071394566,
-0.021544555,
-0.01358157,
0.025741892,
-0.0028059725,
-0.039210558,
0.026671682,
0.009882336,
0.023151763,
-0.008799795,
0.014013259,
-0.01377417,
-0.0038984753,
0.009596758,
0.011104345,
-0.0015266815,
-0.0079497015,
-0.052068222,
-0.004911282,
-0.0036261796,
0.01627132,
0.015673596,
-0.046117567,
-0.021039812,
0.0069202916,
-0.013462027,
-0.012864305,
0.0019160309,
0.0009372612,
0.010559754,
-0.0050972397,
-0.004672193,
0.016311167,
0.000010435489,
0.027335817,
-0.020906985,
-0.00598054,
-0.0058443923,
0.034535047,
-0.020906985,
0.007259001,
-0.014584416,
0.004004737,
0.010134707,
-0.028717218,
0.003304074,
-0.00014424193,
-0.011781763,
-0.003858627,
-0.025555933,
-0.009795998,
0.014146086,
0.005210143,
0.006206346,
-0.01612521,
0.031533152,
0.01740035,
-0.037696328,
0.0015756615,
0.014836786,
-0.010407003,
0.021292184,
0.013315916,
-0.03658058,
0.0024207737,
0.0094107995,
-0.008746664,
-0.036500886,
0.0051105227,
0.001725092,
-0.008175508,
0.004386615,
-0.005509004,
-0.006266118,
-0.0020671217,
-0.012797891,
0.08320289,
0.028106213,
0.00018325988,
-0.02377605,
0.0056783585,
0.00598054,
0.016045513,
-0.0041641295,
-0.011974363,
-0.003005213,
-0.013156524,
0.005157012,
-0.0009231483,
-0.02701703,
0.016776063,
-0.0028690654,
-0.018702054,
0.041601446,
-0.016882325,
0.00026212598,
-0.021796927,
-0.023683071,
0.027734298,
-0.013840583,
0.0026117128,
-0.019352907,
-0.00015399641,
-0.0012934038,
-0.022075864,
-0.0033273187,
0.01411952,
-0.0021003284,
0.018303573,
0.008042681,
-0.011263737,
0.0032675467,
-0.014916483,
-0.0027727657,
0.013103393,
-0.005077316,
-0.01259865,
0.025675477,
0.02475897,
0.017998071,
-0.009689737,
0.03214416,
0.00676422,
-0.012671705,
-0.006256156,
-0.00018554286,
0.0009397517,
0.004678834,
-0.0063159284,
0.021770362,
-0.013521798,
-0.017971506,
-0.025768457,
0.00054542127,
0.017187826,
0.0018828241,
-0.0062229494,
0.006946857,
-0.010612885,
-0.013289351,
-0.0042504673,
-0.16651204,
0.020814005,
0.0095170615,
-0.008069246,
0.022288388,
0.011562599,
-0.0060868016,
0.024134682,
-0.0031978122,
0.0037523655,
0.018569227,
-0.002445679,
-0.028903177,
-0.0038453445,
0.021305466,
0.013681191,
-0.010666016,
0.025848152,
-0.0056484723,
0.019246647,
0.008308335,
-0.016590104,
0.021332031,
-0.015872838,
0.01073907,
-0.00089243206,
-0.0051404084,
-0.029939227,
-0.01627132,
-0.014478154,
-0.015952535,
0.0076109925,
0.022686869,
0.0014096276,
0.033897474,
-0.010227687,
-0.0069534983,
-0.0051005604,
0.0062229494,
0.044337686,
0.022846261,
0.005641831,
-0.002995251,
-0.010526547,
-0.034322523,
0.026605267,
0.0032924516,
0.010592961,
0.01362806,
-0.0062129875,
0.03984813,
-0.022235256,
0.003778931,
0.03363182,
0.026751377,
0.022275103,
0.0033472427,
0.012618574,
0.005611945,
-0.0043766527,
0.01862236,
0.008328259,
0.01122389,
0.015912686,
0.0014860032,
-0.0418671,
-0.011469619,
0.023855746,
-0.014650829,
0.018024636,
-0.00681403,
-0.024453469,
0.01603223,
-0.049385116,
0.02142501,
0.015700163,
-0.022886109,
-0.014810221,
-0.0015665295,
0.019817803,
-0.010028446,
0.025250431,
-0.019751389,
-0.010287459,
-0.016390864,
0.0037324415,
0.007371904,
0.019924065,
0.009444007,
0.0035431627,
-0.0021086303,
-0.018980993,
0.0011555958,
-0.022580607,
0.031692546,
0.01936619,
0.013853866,
-0.00848101,
0.0077969506,
-0.006309287,
0.017825397,
0.00039536814,
-0.011529392,
0.006704448,
-0.0043600495,
-0.010314024,
-0.0042039775,
-0.0055322484,
0.015474357,
0.007750461,
-0.0005890051,
0.019831086,
-0.0006828143,
0.029381353,
-0.009968674,
0.030656494,
-0.005376177,
0.0014785316,
-0.007637558,
-0.035039786,
0.07470196,
-0.0032094347,
-0.0021700626,
0.023311155,
-0.003705876,
-0.03073619,
-0.15312308,
-0.014743808,
0.028292172,
0.01730737,
-0.0010842012,
-0.0011564259,
-0.0030251371,
0.019937348,
-0.018037919,
0.027973386,
-0.024493316,
-0.009370952,
-0.012950642,
-0.0040479056,
0.017905092,
0.006153215,
0.011974363,
-0.0046821553,
-0.034880396,
0.023271307,
-0.025622347,
-0.011117628,
0.0021584404,
-0.008474369,
-0.007172663,
-0.0030184959,
-0.030258013,
0.030497102,
0.009948749,
0.02220869,
0.0014569472,
-0.0124658225,
0.022288388,
-0.002661523,
-0.0291157,
0.021039812,
-0.0066114687,
-0.01504931,
0.03844016,
-0.01607208,
-0.0010435228,
-0.0042670704,
-0.00017049603,
0.0024822063,
-0.00089077174,
-0.0058609955,
0.0021733833,
0.008972471,
-0.000038135906,
-0.026113806,
-0.007278925,
-0.0070132706,
-0.014810221,
-0.01847625,
0.00062387227,
-0.0058908816,
0.0125455195,
0.027920255,
0.0033605255,
0.0149032,
0.0094904965,
-0.008487651,
0.007883288,
-0.014185933,
0.045400303,
-0.017134696,
-0.018396553,
-0.027468644,
0.030284578,
-0.015567335,
0.006940216,
-0.015461074,
-0.016045513,
0.011808329,
-0.024254227,
0.018197313,
-0.0036726692,
-0.0072722835,
-0.002339417,
0.00096465676,
-0.021292184,
-0.016829193,
0.008394673,
0.0025137528,
0.022859544,
-0.017812114,
0.010938311,
0.005455873,
0.01647056,
-0.021305466,
-0.008554065,
0.032808293,
0.01740035,
-0.005362894,
-0.01710813,
0.023297872,
0.001940936,
0.0030566836,
0.020574918,
0.014571132,
-0.008587272,
-0.032755163,
-0.04789745,
0.017626155,
-0.002563563,
0.015328247,
0.021345314,
-0.03658058,
0.0009970334,
-0.029779835,
0.007511372,
0.004828265,
-0.010719147,
-0.010898463,
0.0040379437,
0.004765172,
-0.018715337,
-0.025436388,
0.021185922,
-0.023696354,
0.0018662207,
0.02671153,
0.003470108,
-0.0071793045,
0.034721002,
0.012186886,
-0.005704924,
-0.0090986565,
0.0008899415,
0.012067341,
0.0055322484,
0.012678347,
0.021106226,
-0.027096728,
-0.010612885,
-0.004848189,
-0.027574904,
-0.017480046,
-0.010553113,
0.023204893,
0.011482903,
0.01936619,
0.008965829,
-0.041601446,
-0.0016512069,
-0.022527475,
-0.010712505,
-0.018223878,
-0.046728574,
0.013594854,
0.003245962,
-0.02337757,
0.029195396,
0.014305478,
0.007132815,
-0.031400327,
-0.008992394,
0.019007558,
0.010207762,
-0.003372148,
0.002676466,
-0.02122577,
0.017201109,
0.024440186,
0.021504708,
0.018104333,
-0.00085673475,
-0.024134682,
-0.045692522,
0.015301681,
0.01745348,
-0.003911758,
-0.012671705,
0.011150835,
0.008182149,
-0.0019591996,
-0.0010252591,
0.020920267,
-0.015062593,
-0.013169806,
-0.027601471,
0.009111939,
0.012797891,
0.0029205359,
0.0043401252,
0.009052167,
0.043832943,
0.014703959,
-0.010327307,
0.02623335,
0.000106988075,
-0.0076441993,
-0.0021551196,
0.0072722835,
0.021053094,
0.011091063,
0.010327307,
0.039927825,
-0.0037722895,
0.014956331,
-0.009722943,
0.03039084,
0.01568688,
0.006359097,
0.0124658225,
-0.009729585,
0.013760887,
0.013110034,
-0.040113784,
-0.03740411,
-0.029567312,
0.0046356656,
-0.002789369,
0.0020970078,
0.017958224,
0.011555958,
-0.013156524,
0.018077768,
0.011429772,
0.000022790742,
-0.006053595,
0.018423118,
0.012565443,
0.005973899,
-0.005226746,
-0.0049776956,
0.015075875,
0.009503779,
0.021982884,
-0.00014060993,
0.01750661,
0.0073984694,
0.007810233,
-0.0024240946,
-0.008746664,
0.0030633248,
-0.0043467665,
-0.014358609,
0.014664112,
0.030789321,
-0.03578362,
0.085062474,
0.016258037,
-0.01475709,
0.00411764,
-0.010227687,
0.019751389,
-0.0057514133,
0.019352907,
-0.010280817,
-0.025462955,
0.011403206,
-0.0046655517,
0.02813278,
-0.039582476,
-0.021398446,
0.027043596,
-0.014863352,
0.024134682,
0.0018761827,
-0.025888002,
0.006893726,
-0.013203014,
-0.019087253,
0.005671717,
-0.02401514,
-0.019233363,
0.020282697,
-0.008148942,
-0.009776074,
-0.03108154,
-0.0060270294,
-0.009895619,
-0.0433282,
0.0010850313,
0.0044829147,
-0.02754834,
-0.024227662,
-0.021557838,
-0.011981004,
0.020574918,
-0.000011765056,
0.029248526,
-0.03225042,
-0.01852938,
0.010280817,
0.00087914936,
-0.016364299,
-0.00087831914,
-0.0063790213
] |
Laminin β2 is a component of laminin-521, which is an important constituent of the glomerular basement membrane (GBM). Null mutations in laminin β2 (LAMB2) cause Pierson syndrome, a severe congenital nephrotic syndrome with ocular and neurologic defects. In contrast, patients with LAMB2 missense mutations, such as R246Q, can have less severe extrarenal defects but still exhibit congenital nephrotic syndrome. To investigate how such missense mutations in LAMB2 cause proteinuria, we generated three transgenic lines of mice in which R246Q-m | [
-0.019385478,
0.005396788,
-0.008122032,
-0.022083871,
-0.0238828,
0.013357722,
-0.02146633,
0.0024231847,
-0.042261414,
-0.007786411,
0.004410062,
-0.009263144,
0.00847779,
0.01479418,
-0.0018123542,
-0.008081757,
0.02479569,
0.026863117,
0.017962445,
0.01909013,
-0.003869712,
-0.020956185,
-0.003503885,
-0.023761978,
-0.00011547465,
-0.012156198,
0.0095786275,
-0.043469653,
-0.028890269,
-0.012270309,
0.014659932,
-0.0062022787,
-0.008873823,
0.016056117,
0.010169321,
0.011082211,
0.007282979,
0.028165327,
0.025050763,
-0.012283734,
0.031628937,
0.025426658,
0.010216308,
0.00047406487,
0.0059270696,
-0.01268648,
0.022446342,
-0.0139886895,
-0.03557584,
-0.009310131,
0.0013408065,
0.0019298216,
-0.0071957177,
-0.014807605,
-0.007632025,
-0.009249719,
0.017036129,
-0.0007110973,
0.0030541525,
-0.026728868,
-0.011068786,
0.014176638,
-0.03224648,
0.00003269684,
-0.015774194,
0.009867262,
-0.014310886,
0.02742696,
-0.014498834,
-0.018861908,
0.028380124,
0.027494084,
-0.029266164,
-0.03415281,
0.025909953,
-0.0149552785,
-0.03313252,
-0.0076454496,
-0.041402224,
0.004396637,
0.008229431,
-0.016606534,
-0.016727358,
0.024567468,
0.010827138,
-0.01221661,
0.000004880272,
0.01573392,
0.011350707,
-0.0070547564,
0.002664832,
0.04698696,
0.010384118,
-0.00046693292,
-0.009847124,
0.011901126,
-0.008954372,
0.024527194,
0.00004551862,
-0.0017250928,
0.0041784835,
-0.007209142,
-0.013706768,
-0.009323556,
-0.012954976,
-0.022594016,
0.013894715,
0.0015807756,
0.028836569,
-0.008544914,
-0.009941098,
0.039871793,
-0.0029752816,
-0.044973236,
0.021855649,
-0.008182444,
0.028487524,
-0.018284641,
-0.011854139,
-0.012726754,
0.004396637,
0.016995855,
0.00577604,
-0.018083267,
0.026111325,
0.014230337,
-0.018029569,
-0.011672904,
-0.039791245,
0.007652162,
0.010807001,
0.02412445,
0.02803108,
0.010451242,
0.0037623132,
-0.0019600275,
-0.022406068,
-0.01878136,
-0.03219278,
-0.031199342,
0.005567955,
0.037938613,
-0.023560604,
0.030796597,
-0.011699753,
0.013330872,
0.013216761,
-0.0027168533,
0.0095719155,
0.0077058617,
-0.0044067055,
-0.008383816,
0.009598765,
-0.036381334,
-0.010746589,
0.018096693,
0.0018392039,
0.0433891,
-0.023761978,
-0.007061469,
-0.015371448,
0.010384118,
-0.016432012,
0.008182444,
0.041509625,
0.02656777,
-0.0018039637,
-0.0040375222,
-0.0033260055,
-0.02576228,
-0.0021983185,
0.019533152,
-0.018942459,
0.033266768,
0.016969005,
0.009625615,
-0.0068298904,
-0.0025440084,
-0.012196473,
-0.026030777,
-0.010565354,
0.01651256,
0.018177241,
0.022124147,
-0.018888758,
0.01238442,
0.02385595,
-0.006296253,
0.02135893,
-0.003000453,
-0.011384269,
0.027010791,
0.015116377,
-0.044838987,
-0.6246312,
-0.026769143,
0.028648622,
0.006282828,
0.00078325585,
0.023748552,
-0.0014062526,
-0.0062157037,
-0.011263446,
0.0075112013,
-0.0031044956,
0.023050461,
0.0154519975,
-0.009592053,
0.003916699,
-0.03208538,
0.007504489,
0.009887399,
0.009981373,
-0.0069473577,
-0.012156198,
0.014418284,
0.005071236,
0.021077009,
0.01371348,
0.025359534,
0.032837175,
-0.033347316,
0.006380158,
0.013632931,
-0.046396267,
0.030850297,
0.007309829,
-0.0024869528,
0.04443624,
-0.0009439345,
-0.016082965,
0.01909013,
0.031145643,
0.021707976,
-0.0070547564,
-0.012814015,
0.032837175,
-0.008659026,
-0.0019466027,
0.02805793,
0.021882499,
0.015599671,
0.0063197464,
-0.0061351545,
0.012404557,
0.00036750516,
-0.029776309,
-0.019492876,
0.011491668,
0.01661996,
0.012840865,
-0.0149687035,
0.03133359,
-0.006292897,
-0.012639493,
0.030071655,
-0.002522193,
-0.0095517775,
-0.0031430922,
-0.013619507,
-0.014136363,
0.017935595,
0.0023996911,
-0.006682217,
0.018217515,
0.04435569,
0.016942156,
0.009243007,
0.015827894,
0.01833834,
0.02271484,
0.017103253,
-0.008638889,
0.0124851065,
-0.003950261,
0.003856287,
-0.02135893,
0.0039099865,
0.03165579,
0.0075112013,
-0.04161702,
0.014391435,
-0.017358325,
-0.0027067845,
0.008410666,
-0.00032366466,
-0.012552231,
-0.029212466,
-0.012136061,
0.005729053,
0.0006599151,
0.034179658,
-0.0012837509,
-0.016713934,
-0.022473192,
0.017653672,
0.0042489637,
-0.024674866,
0.024231847,
0.011907838,
-0.04014029,
0.018083267,
0.022312094,
-0.028084777,
-0.007444077,
-0.023668004,
0.0045006797,
-0.020701112,
0.015559397,
-0.029937407,
0.0059472066,
-0.019412328,
0.0017217365,
-0.015196926,
-0.0045375978,
-0.0042321826,
0.0019482807,
0.01027672,
0.006504338,
0.014458559,
0.009826987,
-0.015143226,
-0.008417378,
-0.009296706,
-0.014230337,
-0.01623064,
0.023775402,
-0.018029569,
0.02690339,
-0.02146633,
0.018486014,
-0.0062861843,
0.008873823,
-0.027977379,
-0.0051014414,
-0.019331777,
0.0014372976,
-0.0040274537,
-0.0076118875,
-0.017062979,
-0.015787618,
0.008289843,
0.00067585707,
-0.0017250928,
-0.010075347,
0.002475206,
0.016606534,
0.024607742,
0.014552533,
-0.011082211,
0.0005390915,
-0.0010999984,
0.0072695543,
0.0010538504,
-0.0022939707,
-0.012344146,
-0.009632327,
-0.0011058718,
-0.00036771494,
-0.02693024,
-0.006873521,
0.01069289,
-0.0217214,
-0.04081153,
-0.019815072,
-0.016888456,
-0.025695154,
-0.0016739105,
0.01351882,
0.01872766,
0.0030742898,
-0.0009581984,
0.008108607,
0.0100417845,
0.0066385865,
-0.0090550585,
0.0038093,
-0.019882197,
0.024366096,
0.016002417,
0.052786496,
0.019452602,
0.008021345,
0.024285546,
-0.009209445,
0.019143831,
-0.01576077,
-0.0013240254,
0.004618147,
-0.015358024,
0.033669513,
-0.013720193,
0.0040475912,
0.024070749,
0.0062559783,
-0.03256868,
-0.005044386,
-0.012652918,
0.022620866,
-0.042449363,
-0.007685724,
-0.017908745,
0.012713329,
0.0008742931,
0.0023141077,
0.009665889,
-0.015358024,
-0.02786998,
0.011263446,
0.0046047224,
-0.013384571,
0.0012510278,
-0.004732258,
-0.017962445,
-0.0063197464,
0.00963904,
0.02687654,
0.0007836754,
-0.010907687,
0.0173986,
0.012961688,
0.017277777,
0.002332567,
-0.022486618,
-0.02323841,
0.021667702,
0.010330419,
0.009914249,
-0.04263731,
-0.022594016,
0.010102197,
-0.005494118,
0.027010791,
0.0012837509,
0.007585038,
-0.00031401555,
0.0070547564,
0.0071487306,
0.01576077,
-0.020647414,
0.016445436,
0.04647682,
-0.0021446191,
0.022083871,
-0.007309829,
0.020741386,
-0.017412025,
0.00980685,
-0.0043362253,
-0.012518669,
0.020566864,
0.010813713,
0.04014029,
0.0173986,
0.024272121,
0.0068332464,
-0.015787618,
-0.015425148,
0.01623064,
0.00045602524,
0.006108305,
-0.018942459,
0.0006628518,
0.0058935075,
-0.02016412,
-0.0046282155,
0.0019147187,
-0.050477423,
-0.0006108305,
-0.0034132672,
0.02476884,
0.018566562,
0.02000302,
0.007585038,
-0.011256733,
-0.03995234,
0.028192177,
0.019801648,
-0.018526288,
-0.006581531,
-0.015049253,
-0.011612492,
-0.018526288,
0.007142018,
0.017519424,
-0.007974358,
0.012807303,
-0.004900069,
0.00094141735,
-0.016244063,
0.012236747,
-0.010229733,
0.013471833,
-0.006188854,
-0.00015270762,
-0.0008591901,
-0.0005239885,
-0.0120353745,
0.035602693,
0.02781628,
-0.014163213,
-0.0015950395,
-0.016297763,
-0.034287058,
0.012156198,
-0.018405464,
0.0008449262,
-0.021600578,
-0.0011369167,
-0.0055914484,
0.013216761,
0.010652616,
0.007444077,
0.005631723,
-0.027520934,
-0.035119396,
0.007786411,
0.0014255508,
-0.0011704788,
0.02693024,
-0.001619372,
0.025842829,
0.01570707,
0.008853686,
-0.001760333,
-0.029293014,
0.009041633,
-0.02271484,
-0.013673206,
-0.0025154806,
0.0062895403,
0.008981222,
-0.0074373647,
0.009061771,
0.006074743,
-0.036327634,
0.019600276,
0.008813411,
-0.0030591867,
0.011565505,
0.02789683,
0.038636707,
0.014445134,
-0.0004921045,
0.004554379,
0.008793274,
-0.0003981306,
-0.02141263,
-0.012491819,
-0.0057055596,
-0.024500344,
0.0073366784,
0.01180044,
-0.008766425,
0.0045711603,
0.001682301,
0.011854139,
0.018271215,
0.01133057,
0.02227182,
0.011760165,
0.011001661,
0.0017452299,
-0.023386082,
-0.013397996,
-0.014136363,
0.015183501,
-0.009739726,
0.012417982,
-0.014565958,
-0.009149033,
-0.01651256,
0.016364887,
-0.0031179206,
0.005252471,
-0.005819671,
0.007598463,
-0.020875636,
-0.004762464,
-0.033454716,
-0.017801346,
-0.009303418,
-0.008638889,
-0.007571613,
-0.027051065,
0.015599671,
-0.025574332,
-0.008457653,
0.017116679,
-0.022124147,
-0.03160209,
-0.016915306,
0.026769143,
0.036005437,
0.026071051,
-0.027467234,
0.009028209,
0.026460372,
0.0003517729,
-0.027494084,
0.004477186,
-0.011901126,
0.01964055,
0.004493967,
0.017371751,
-0.02318471,
-0.035656393,
-0.0060512493,
0.020352067,
-0.020284943,
0.0000520475,
0.003460254,
0.0023728416,
-0.0071957177,
-0.0034031984,
0.0032739844,
-0.0031934353,
-0.023332382,
0.01282744,
-0.030313302,
-0.008967797,
-0.036085986,
-0.018217515,
0.015774194,
0.009008071,
-0.009786713,
-0.011243309,
-0.018163817,
-0.010155896,
-0.012505244,
0.023654578,
0.0018543069,
0.0046886276,
-0.0032622376,
-0.0038797804,
0.0022939707,
0.03256868,
-0.014659932,
0.013351009,
-0.023050461,
0.020607138,
-0.030823447,
-0.009873974,
0.014700206,
0.020432616,
-0.018217515,
-0.010129047,
-0.0031800105,
0.002773909,
0.03850246,
0.031145643,
0.005786109,
-0.032917723,
0.0040677283,
-0.0037220386,
-0.012183048,
-0.02083536,
0.006172073,
-0.0074910643,
0.004393281,
0.0001637202,
0.010209596,
-0.0008390529,
-0.027359836,
-0.014713631,
0.00035429007,
-0.0075447634,
0.009632327,
-0.01623064,
0.030930845,
-0.03493145,
-0.019828498,
-0.00806162,
-0.02740011,
-0.01568022,
-0.010598916,
0.008967797,
0.033830613,
0.04116058,
0.007410515,
0.028943969,
0.013760467,
0.0154519975,
0.022137571,
-0.007142018,
0.00786696,
-0.03208538,
0.006410364,
0.0115386555,
0.004141565,
0.0348509,
-0.019385478,
0.019143831,
0.02019097,
-0.009444379,
-0.0067426288,
0.0021395849,
-0.03146784,
-0.02323841,
0.010397543,
-0.02133208,
0.0238828,
-0.027655182,
-0.021426054,
-0.008222718,
-0.013391284,
-0.01568022,
-0.02651407,
0.024527194,
-0.016109815,
0.038717255,
0.010169321,
0.016875032,
0.019962747,
-0.018432314,
0.024983639,
0.0023795539,
-0.0070211943,
-0.014176638,
0.017734222,
0.002842711,
-0.0052726083,
-0.004017385,
-0.008236143,
-0.034125958,
-0.007772986,
-0.008410666,
0.00491685,
-0.029695759,
-0.020016445,
-0.030393852,
-0.036193386,
0.005242402,
0.01781477,
-0.01659311,
0.021493178,
-0.021117283,
-0.02446007,
0.010746589,
-0.01002836,
0.034287058,
-0.0154385725,
0.028084777,
0.009927673,
-0.02958836,
-0.033723213,
-0.008887248,
0.00238291,
0.0026413384,
0.03213908,
0.018982733,
-0.0067829033,
-0.01027672,
0.004235539,
-0.0030256247,
-0.016297763,
-0.044812135,
0.03318622,
-0.0016688762,
-0.012518669,
-0.00047951873,
-0.009001359,
-0.020821936,
0.0018559849,
-0.035951737,
-0.015532547,
-0.033374168,
0.0034938161,
-0.0007966807,
-0.0021311943,
-0.0019969458,
0.0036750515,
-0.018512862,
-0.023842527,
0.021667702,
-0.019815072,
0.0067392727,
0.010800289,
0.016673658,
0.034072258,
-0.004822876,
-0.0047859577,
0.00120488,
-0.00008453458,
-0.01002836,
0.009108758,
0.0021630784,
0.04116058,
-0.0060546054,
-0.015076102,
0.028541222,
0.021211257,
0.03232703,
-0.0031464484,
-0.0023224985,
-0.019801648,
-0.010934537,
0.017626822,
0.03050125,
0.014901579,
-0.023077311,
0.026836267,
-0.013800742,
-0.016499136,
-0.03764327,
-0.020110419,
-0.0041952645,
-0.05514927,
-0.0031162424,
-0.018647112,
0.0085516265,
0.006074743,
0.011706466,
-0.006819822,
0.0149687035,
0.026097901,
-0.014431709,
0.026366398,
0.0008457653,
0.009605478,
-0.029856857,
-0.008330117,
-0.008820124,
0.0048463694,
0.00806162,
-0.013035526,
-0.000999312,
-0.010088772,
0.00491685,
0.012834153,
0.0004220436,
-0.028621772,
0.02360088,
-0.016029267,
0.035226796,
-0.008799987,
0.008900673,
0.0100484975,
-0.005242402,
0.014606233,
-0.02958836,
0.0030122,
-0.021761676,
0.015035828,
-0.02800423,
-0.008370391,
-0.014861304,
-0.0062626908,
0.001840882,
0.01180044,
0.01110906,
0.0026564414,
-0.022540316,
-0.019049857,
-0.012867715,
0.015599671,
0.013216761,
-0.0124851065,
-0.012055512,
-0.013095938,
-0.00007105729,
0.03839506,
-0.03592489,
-0.008987934,
-0.005564599,
-0.02742696,
-0.008826836,
-0.013867866,
-0.011444681,
0.03208538,
-0.00015029535,
0.008430803,
-0.015545972,
-0.008484502,
-0.03404541,
-0.019009583,
0.006521119,
-0.0003861741,
-0.0033813831,
0.020123845,
0.004077797,
0.01027672,
-0.014096089,
0.003826081,
-0.018096693,
-0.013773892,
0.0086993,
-0.024540618,
0.053054992,
-0.0037253948,
-0.03050125,
-0.010800289,
0.039630145,
0.009289994,
-0.007222567,
0.017277777,
-0.015196926,
-0.002094276,
0.000666208,
0.013894715,
0.016633384,
0.012787166,
0.004510748,
-0.014257186,
-0.0090684835,
-0.008390529,
0.014082664,
0.0002697555,
0.017707372,
0.027762583,
0.0085784765,
0.0051819906,
0.009041633,
0.011350707,
0.015666796,
-0.003349499,
0.03133359,
0.016472286,
0.0008277257,
0.018136967,
0.018647112,
0.0040475912,
-0.006396939,
0.0057995333,
0.012679767,
-0.011679616,
0.003869712,
-0.007376953,
-0.003045762,
0.021009885,
-0.00717558,
-0.0436039,
-0.014055814,
0.02000302,
-0.00978,
-0.015062678,
0.017908745,
0.0046382844,
-0.0018375257,
-0.011887701,
-0.0304744,
-0.004342938,
0.008779849,
0.0006456512,
-0.002127838,
0.010196171,
-0.0095853405,
0.019895623,
-0.0025725362,
-0.014002115,
-0.014297461,
-0.017331475,
-0.0007555671,
-0.011156047,
0.19063282,
-0.012532094,
0.0144719845,
0.0038294373,
-0.0012115923,
-0.009759863,
-0.0008285647,
0.0010739877,
0.0027873337,
0.011625917,
0.014606233,
-0.0072024297,
-0.009793425,
0.006756054,
0.026916817,
-0.012780453,
-0.02055344,
-0.015384873,
-0.031843733,
-0.0068164654,
0.0072158547,
0.0057089156,
0.029319864,
-0.002841033,
0.031736337,
0.012760316,
-0.024728566,
0.0016873353,
0.033401016,
0.0085650515,
-0.01695558,
0.00094225636,
-0.01870081,
-0.0053699384,
0.0029098354,
0.0075783255,
-0.012760316,
-0.008679163,
0.004460405,
0.022150995,
-0.019600276,
0.035226796,
-0.0016453827,
0.013639644,
-0.019989595,
0.00043043413,
-0.0074776392,
-0.031709485,
-0.02576228,
0.025185011,
-0.033562116,
0.037428472,
0.007088319,
0.0069876323,
-0.00889396,
-0.017573124,
0.0012946586,
0.0105586415,
-0.01664681,
0.013169774,
-0.03130674,
0.011149335,
-0.021546878,
0.02232552,
-0.007994496,
0.03404541,
-0.009256431,
-0.0067057107,
-0.02271484,
-0.0436039,
0.012156198,
0.0012015237,
-0.019170681,
0.014391435,
-0.025426658,
-0.0072695543,
0.013773892,
0.034340758,
-0.0009758185,
0.024298972,
0.0077259988,
0.016029267,
-0.018150391,
-0.013310735,
-0.019707674,
-0.036166534,
-0.010941249,
0.0075917505,
0.004953768,
-0.01196825,
0.024862815,
-0.027977379,
-0.008330117,
0.012082362,
0.0025775705,
-0.019143831,
-0.018553138,
-0.0047356146,
-0.00612173,
-0.010122334,
-0.03154839,
0.061593194,
0.009155745,
-0.0070547564,
-0.005507543,
-0.013136212,
-0.009330268,
0.023023611,
-0.007457502,
0.0076387376,
-0.017344901,
-0.024272121,
-0.015062678,
-0.016660234,
0.01180044,
0.023372658,
0.024178147,
0.010270007,
0.02055344,
0.007296404,
-0.011223171,
-0.010256582,
0.014874729,
0.015022403,
-0.030769747,
0.013579232,
-0.016995855,
0.010162609,
-0.010196171,
-0.029454112,
-0.010780151,
-0.0015824537,
0.007189005,
-0.014203487,
-0.008632176,
-0.005967344,
-0.000570556,
-0.011243309,
-0.010310282,
0.023090735,
0.0006305482,
-0.023466632,
0.006396939,
-0.012746891,
0.0010966421,
0.0003557584,
0.016002417,
0.025869679,
-0.023761978,
0.00266651,
-0.03125304,
-0.023399506,
-0.006292897,
-0.0062291287,
0.02310416,
-0.016338037,
-0.01160578,
-0.03818026,
0.007222567,
0.0115252305,
-0.021681126,
0.021493178,
0.013773892,
-0.021600578,
0.0019902333,
-0.009041633,
-0.16936786,
0.00022906144,
0.009410817,
-0.0129751135,
0.003950261,
0.0074239396,
-0.0062425532,
0.00678626,
0.0018073199,
0.0062157037,
0.042959508,
-0.011813864,
-0.0085516265,
-0.03310567,
-0.015331174,
-0.0028796294,
-0.00781326,
0.015519122,
0.008155594,
0.009860549,
0.017774496,
-0.041536473,
0.020419192,
0.0070480444,
0.008363679,
0.023090735,
0.009102046,
0.00830998,
0.008806699,
-0.026702018,
0.002698394,
0.011431256,
0.045725025,
0.0049940427,
0.0125253815,
-0.005668641,
0.012646205,
-0.004802739,
-0.019116981,
-0.014686782,
0.011948113,
0.03557584,
-0.0025574332,
0.00024206676,
-0.004685271,
0.03136044,
0.022594016,
0.002951788,
0.019882197,
-0.0032303536,
0.030635498,
-0.022312094,
0.026379822,
0.020768236,
0.014915004,
0.02169455,
-0.018123543,
0.019788222,
-0.008397241,
-0.002731956,
-0.02000302,
-0.018271215,
0.035307344,
-0.009357118,
-0.00128459,
-0.020284943,
0.0021026665,
-0.01180044,
-0.03984494,
0.008068332,
-0.032702927,
-0.02690339,
0.016445436,
-0.0065781744,
0.028272726,
0.03055495,
-0.010108909,
0.012196473,
0.013243611,
-0.009665889,
-0.0045308857,
0.014512259,
-0.034689803,
0.012505244,
-0.02385595,
-0.00069599436,
0.022150995,
0.017586548,
0.015411723,
-0.013230186,
0.0058935075,
-0.025278986,
0.036864627,
-0.033213068,
0.017089829,
0.017143529,
-0.0007731872,
0.017318051,
-0.0060713864,
0.013585944,
0.016002417,
-0.009370542,
-0.02745381,
0.0028343205,
0.021036733,
-0.011719891,
-0.008773137,
0.01479418,
0.0478193,
-0.022741688,
0.019774798,
-0.0149552785,
-0.005326308,
0.021224681,
-0.006447282,
-0.0007287174,
-0.02005672,
0.010786864,
-0.008511352,
-0.019358627,
0.049349733,
-0.006776191,
0.019600276,
-0.007860247,
0.024164723,
-0.021734826,
-0.11824604,
-0.037267372,
0.017613398,
0.027467234,
-0.0025322617,
0.0074507897,
0.0009724623,
0.0064539947,
-0.0012736822,
0.036085986,
-0.039818093,
-0.018136967,
-0.0044973237,
0.001268648,
0.010746589,
-0.0021949622,
0.013471833,
0.0011041936,
-0.037294224,
0.015962142,
-0.0003274404,
-0.0053867195,
0.013646356,
-0.0023963351,
-0.01903643,
-0.0217214,
-0.0305281,
0.004970549,
-0.012424695,
0.0043664314,
0.009652465,
-0.021278381,
0.005269252,
-0.008390529,
-0.0019298216,
-0.031897433,
-0.015089527,
0.0060344683,
0.039066304,
0.0048497254,
-0.008316692,
0.011236596,
0.0115386555,
-0.0007757044,
-0.03203168,
0.009357118,
-0.01690188,
0.029346714,
0.046449967,
-0.02086221,
-0.003970398,
-0.023345808,
-0.02529241,
-0.010773439,
0.033776913,
-0.012431407,
-0.0060478933,
0.04806095,
-0.026742293,
0.012894564,
-0.0064372136,
-0.00256918,
0.0017519424,
0.011672904,
-0.00047532347,
-0.008356967,
-0.029293014,
-0.04878589,
0.03662298,
-0.02055344,
0.012404557,
0.004014029,
-0.0018962595,
-0.005712272,
-0.022701414,
0.01565337,
0.0019549932,
-0.0062694033,
0.008068332,
0.0043731434,
-0.012162911,
0.0054504876,
0.023990199,
0.0032538471,
0.007913947,
0.013854441,
0.0059740567,
0.009914249,
0.009128896,
-0.010323707,
-0.009511503,
0.04196607,
0.033535264,
-0.0174523,
0.0034132672,
-0.000888557,
-0.030823447,
-0.036059137,
0.022124147,
0.019962747,
-0.045537077,
-0.012954976,
-0.068359315,
0.012270309,
-0.0059572756,
-0.015868168,
0.024594318,
-0.009464516,
0.016432012,
-0.009437667,
-0.0085516265,
0.0072896914,
-0.03415281,
0.040730983,
-0.009457804,
-0.013122787,
-0.018606836,
-0.013189911,
0.04698696,
0.031843733,
0.0003284892,
0.042207714,
-0.001777114,
-0.0013911497,
-0.010820426,
0.015895018,
-0.00022717357,
-0.007907234,
-0.030796597,
0.011921263,
-0.003681764,
-0.0068802335,
0.015545972,
-0.021963049,
-0.0016445436,
0.0024802403,
0.0017620111,
-0.03055495,
0.02266114,
0.013760467,
0.029051367,
0.029024517,
-0.016848182,
-0.027386686,
0.025842829,
0.016203789,
0.01778792,
0.00006135574,
-0.050208922,
0.0095517775,
0.007699149,
-0.013800742,
0.03160209,
-0.00574919,
-0.008081757,
-0.029051367,
-0.024151297,
0.0050074677,
0.0110352235,
0.010243158,
0.001587488,
-0.0013693343,
0.033642665,
-0.000021854705,
0.020298367,
-0.007826685,
0.015935292,
-0.011451393,
-0.018687386,
0.015505698,
-0.006299609,
-0.02531926,
-0.008135457,
-0.022150995,
-0.0072695543,
0.020727962,
-0.008316692,
0.011404406,
0.0025507207,
-0.021050159,
-0.0074910643,
0.027682032,
0.028272726,
0.0024533905,
-0.026191875,
-0.011250021,
0.014270611,
-0.015559397,
0.0027722307,
0.017277777,
0.020633988,
0.022500042,
0.00555453,
0.021909349,
0.005937138,
0.011719891,
0.01479418,
0.02088906,
0.0050108237,
0.013364434,
0.010746589,
0.01742545,
-0.02531926,
0.0013147958,
-0.0011612492,
-0.022594016,
-0.0044872547,
0.014565958,
-0.026997365,
-0.04183182,
0.011115773,
-0.0061821416,
0.0037388196,
0.0031766542,
0.0040475912,
0.0100619225,
-0.0025960295,
-0.008403953,
0.0047859577,
0.0044536926,
-0.012666342,
0.02484939,
0.021063583,
0.00070522394,
-0.002857814,
0.0034669666,
0.015425148,
0.012176336,
0.028299576,
-0.018942459,
-0.0016915306,
-0.012263597,
-0.0011058718,
-0.02094276,
-0.02349348,
0.014995553,
0.007350103,
0.0019717743,
-0.0023023612,
0.025789129,
0.00046064003,
0.09316843,
0.007376953,
-0.024070749,
0.017492574,
-0.028326426,
0.004104647,
-0.015344599,
0.018405464,
0.003715326,
-0.03391116,
-0.002535618,
-0.0071822926,
0.018445738,
-0.022822239,
-0.026044201,
-0.003347821,
0.0095584905,
-0.00073039555,
-0.010565354,
-0.005225621,
0.036005437,
-0.0065446123,
0.004309376,
0.012062225,
-0.0051182224,
0.0057592588,
0.038233962,
-0.003936836,
-0.01875451,
-0.020956185,
-0.004906781,
0.015948717,
-0.04277156,
-0.02258059,
0.018136967,
-0.024661442,
0.025722004,
-0.0069406456,
-0.006208991,
-0.005410213,
0.015854742,
0.0034904599,
-0.022137571,
-0.041375376,
0.008813411,
-0.026191875,
-0.03654243,
-0.013122787,
-0.024057325
] |
BACKGROUND ST2 is an interleukin (IL)-1 receptor family member with membrane-bound (ST2L) and soluble (sST2) isoforms, and sST2 is a biomarker for poor outcome in patients with myocardial infarction (MI). IL-33, the recently discovered ligand for ST2, activates nuclear factor kappaB and thus may regulate apoptotic cell death. We tested the hypothesis that IL-33 is cardioprotective after MI through ST2 signaling. METHODS AND RESULTS IL-33 protected cultured cardiomyocytes from hypoxia-induced apoptosis, and this cardioprotection was partially | [
-0.021870926,
0.0004528845,
-0.025951026,
-0.023275116,
-0.009120613,
0.018651886,
-0.028905125,
0.024454106,
-0.013432537,
-0.005772414,
0.015393105,
-0.0072792694,
-0.0045901127,
0.00686861,
0.009922062,
-0.0047656363,
0.035343204,
0.00965712,
0.013220584,
0.022202102,
-0.017578874,
0.03454838,
-0.0018628704,
0.007577329,
0.010332721,
0.017406661,
0.012637713,
-0.05028591,
-0.011180534,
-0.013313314,
-0.0027322099,
-0.005719426,
-0.046735693,
-0.0008999734,
-0.0077031762,
-0.017260943,
0.011928994,
-0.013439161,
-0.007173293,
0.0022735298,
0.012710571,
0.008199941,
0.010557922,
-0.028481219,
-0.011571323,
-0.0052988315,
0.009882321,
-0.026083497,
-0.024533588,
0.01695626,
0.011233523,
-0.0085973535,
-0.010690392,
-0.007987988,
-0.016134942,
-0.012637713,
-0.0011549797,
-0.006444704,
0.016307153,
-0.022003397,
-0.010822863,
-0.010968581,
-0.01736692,
0.0046464126,
0.013803456,
-0.0014538668,
-0.009445167,
0.032561317,
-0.007001081,
0.02240081,
0.02330161,
0.042470135,
-0.012889408,
0.012260171,
0.0022950564,
-0.006477821,
-0.024652813,
-0.003164396,
-0.00013133236,
0.0018761174,
0.031316094,
-0.027394958,
-0.0036429465,
0.017446402,
0.026467662,
-0.0120482175,
-0.0089947665,
0.0061764503,
-0.003132934,
-0.00192745,
0.033700567,
0.035157748,
-0.0016956261,
0.032852754,
-0.024772037,
0.011717041,
-0.0063850917,
0.009723355,
0.0020218354,
-0.030441785,
-0.0020284588,
-0.042205192,
0.012909277,
-0.0073653758,
-0.049305625,
-0.0063453503,
0.002543439,
0.0011392487,
0.03301172,
-0.0050073955,
-0.03301172,
0.045675926,
0.011789899,
-0.024719048,
0.050736308,
-0.0142406095,
0.0064579505,
-0.00707394,
-0.0063354154,
0.00005862867,
0.017419908,
0.017101979,
0.026891569,
-0.015658047,
0.013485526,
-0.006789128,
-0.020016335,
-0.018651886,
-0.03677389,
0.012982137,
0.01763186,
0.007908505,
-0.0032587813,
0.0022619385,
-0.012584724,
0.007219658,
-0.0008395336,
-0.0057558557,
0.002831563,
-0.030229833,
0.013353055,
0.020466736,
-0.00003120308,
-0.009703485,
0.0004212157,
0.011491841,
0.03817808,
0.013935926,
0.00039720535,
0.0013636211,
-0.025036978,
-0.038390033,
-0.000991047,
-0.016360141,
-0.01791005,
0.017446402,
-0.007835647,
0.043158982,
-0.0131675955,
-0.0047093364,
0.008226436,
-0.0047093364,
0.0046960893,
0.0019191705,
0.041675307,
0.021195326,
-0.005490914,
0.0046795304,
-0.022692244,
-0.019102287,
0.0057260497,
0.014134632,
-0.0066367863,
0.024361378,
-0.0029276044,
0.014002162,
0.007067316,
0.01590974,
-0.00069340173,
-0.028348748,
-0.014849975,
0.005732673,
0.014081644,
0.010246615,
-0.02199015,
0.015022187,
0.028481219,
0.0010158853,
0.009577638,
-0.009935309,
0.007027575,
0.012147571,
0.0045437478,
-0.009928686,
-0.6405227,
-0.019804383,
0.009908815,
0.000001486092,
0.004176141,
0.028507713,
-0.000934747,
-0.005444549,
-0.016585343,
0.032746777,
-0.0044477065,
0.012021723,
-0.0030567632,
-0.00249873,
-0.02058596,
-0.050921768,
-0.01330669,
-0.019645417,
0.01063078,
-0.0013603093,
-0.009286202,
0.0022735298,
-0.0085046245,
0.02988541,
0.001249365,
0.021367537,
0.02466606,
-0.0358201,
-0.017525885,
0.044960584,
-0.00881593,
0.026202722,
0.008180071,
0.0033117696,
0.054260034,
-0.010564545,
-0.008981519,
0.033038214,
0.029302537,
-0.0036561936,
-0.0018761174,
-0.0049246014,
0.014412821,
-0.006236062,
-0.0075110933,
0.01618793,
0.017976286,
0.020532971,
-0.0019489764,
0.0004872441,
0.01832071,
-0.0056266966,
-0.011021569,
0.014267104,
0.014306844,
0.0017353672,
0.028693171,
-0.01704899,
-0.003520411,
0.019791136,
0.013141101,
0.01545934,
-0.0040370473,
-0.0077230465,
0.009193473,
0.00061309134,
-0.012187312,
-0.004053606,
0.0023331416,
0.014783739,
0.009498155,
0.026507404,
0.021698715,
0.009829332,
0.014677763,
0.037250783,
0.0031528047,
0.018069014,
-0.0018943322,
0.017804073,
0.010968581,
-0.005848585,
-0.013326561,
-0.01469101,
0.02285121,
0.033382636,
-0.020360759,
0.002371227,
0.016704565,
0.018439934,
-0.0017436467,
-0.014638022,
-0.03237586,
-0.031157129,
0.006722892,
0.031024657,
-0.01446581,
0.012260171,
0.022321327,
-0.020519724,
0.0014919522,
0.0120482175,
-0.0052690255,
0.007113681,
0.028772654,
-0.000087451415,
-0.04265559,
-0.010127392,
0.040959965,
-0.031448565,
0.0066467216,
-0.0047358307,
-0.029037595,
-0.014439316,
0.0026196097,
-0.022970434,
0.005735985,
0.014585033,
0.002715651,
-0.036747396,
0.02348707,
-0.015300375,
0.0031958576,
-0.008080718,
0.0003206207,
0.024931,
0.014002162,
0.003838341,
-0.003205793,
-0.013631243,
0.008941778,
0.015578564,
0.027421452,
-0.011061311,
0.005692932,
-0.005818779,
0.021407278,
-0.00070250913,
0.007835647,
-0.017592119,
-0.037621703,
-0.0057558557,
0.02588479,
-0.021473514,
-0.010398956,
-0.030733222,
0.00025790406,
0.00024900367,
0.014624774,
-0.014876469,
-0.020095818,
-0.013710726,
-0.019075792,
-0.0025020419,
0.014081644,
-0.01841344,
0.002631201,
-0.029620467,
0.0014687699,
-0.029011102,
-0.0059976145,
0.02208288,
-0.018930076,
-0.0055538374,
-0.024493847,
-0.007577329,
-0.0074249874,
0.0067659453,
0.00249873,
-0.03722429,
-0.010239991,
0.0005360927,
-0.02253328,
-0.0042754947,
0.014214115,
0.017313931,
-0.0028977983,
-0.011491841,
-0.015008939,
0.0032538136,
-0.0003274512,
-0.03237586,
-0.0031677077,
0.00023989631,
0.01704899,
0.013525267,
0.023844741,
0.010591039,
0.0069745868,
0.015088422,
0.0024060006,
0.0020069324,
-0.003924447,
0.033170685,
0.0015788862,
-0.006987834,
0.012140947,
0.00022313047,
0.009080872,
0.013617996,
-0.004669595,
-0.0028895189,
0.012730442,
-0.019261252,
0.0014099859,
-0.009842579,
0.0057691024,
-0.02285121,
0.03563464,
0.0000697024,
0.020374006,
0.014545292,
-0.0039741234,
-0.014267104,
0.008146953,
0.004798754,
0.016890025,
-0.011193781,
0.00900139,
-0.014611527,
0.0192745,
0.0007463901,
-0.008564237,
-0.019459957,
0.0021062854,
-0.010769875,
0.02475879,
0.0063188565,
0.001193065,
-0.018850593,
-0.006855363,
-0.014942705,
0.019300994,
0.013233831,
0.012624466,
0.0031080958,
0.0014604904,
-0.014094891,
0.054789916,
0.00836553,
-0.006527498,
0.0018678381,
0.0010448633,
-0.0022751857,
0.020056076,
-0.0026229215,
0.030070867,
0.0068023745,
-0.023275116,
0.030017879,
0.0007646048,
0.013935926,
-0.017976286,
0.009299449,
0.0005050449,
0.0038747704,
0.008358906,
0.0064546387,
0.04421875,
0.01137924,
0.02752743,
0.0009513058,
-0.0029805927,
-0.0069149747,
0.009412049,
0.031051151,
-0.010604287,
-0.009902191,
0.0033597902,
-0.007835647,
-0.021142337,
0.01845318,
-0.015499081,
-0.025739074,
0.0070209517,
0.0018744615,
0.045490466,
0.017340425,
-0.005179608,
0.001996997,
0.0031677077,
-0.03791314,
0.017804073,
0.028189782,
-0.012962266,
0.006656657,
-0.026123239,
-0.015485834,
-0.0064877565,
0.0056300084,
-0.0029276044,
0.013816703,
0.034124475,
-0.013386172,
-0.008206565,
0.0052822726,
0.021394031,
-0.03187247,
0.024228906,
-0.021764949,
0.024202412,
-0.0007749541,
-0.0048947954,
-0.0020532971,
0.04339743,
0.012485371,
0.011816394,
0.0098690735,
-0.014094891,
-0.0011897532,
0.0068288688,
-0.021314548,
0.00482856,
-0.016545601,
0.011028193,
0.005504161,
0.014094891,
0.0014298565,
0.009776344,
-0.012511865,
-0.012167442,
-0.0326408,
-0.002828251,
-0.011703794,
0.009253084,
0.02996489,
0.022135869,
0.0013470623,
0.010299603,
0.009776344,
-0.02348707,
-0.026692864,
0.009597508,
-0.017605366,
0.0120482175,
-0.014492304,
-0.014227362,
-0.0060241087,
0.013604749,
0.016572095,
0.018347204,
-0.010750004,
0.0012684078,
-0.00024962463,
0.008617224,
0.0037886645,
0.016108448,
0.059823807,
0.019115534,
-0.01469101,
-0.0029789368,
0.03791314,
0.0030534517,
-0.04098646,
0.0022834651,
0.009200096,
0.0031279663,
0.0005928067,
-0.010120768,
-0.008862295,
-0.01405515,
0.015220893,
-0.0034906052,
0.018347204,
0.01936723,
0.022837963,
0.003907888,
0.0107897455,
0.003894641,
-0.012253547,
0.0021990149,
0.018439934,
0.010167132,
-0.01124677,
0.023381094,
-0.018545909,
-0.0125383595,
-0.02240081,
0.026229216,
-0.019261252,
0.0019224823,
0.003220696,
-0.011577946,
0.0014845007,
-0.0067195804,
-0.033382636,
0.03335614,
-0.016015718,
0.013697479,
-0.01736692,
-0.013922679,
-0.006183074,
-0.015896494,
-0.007345505,
0.022016644,
-0.0033101137,
-0.021658974,
-0.0008825866,
-0.0038847057,
0.012584724,
0.0015308654,
-0.005735985,
-0.0116773,
0.03759521,
-0.00686861,
-0.012843043,
0.003464111,
-0.03817808,
0.011895876,
-0.0040867236,
-0.01745965,
-0.022877704,
-0.0104983095,
0.014121385,
0.0031561165,
-0.009266331,
-0.01867838,
-0.019658664,
-0.009518025,
0.02444086,
0.040615544,
-0.022188855,
-0.0043980298,
0.0045338124,
-0.0025947716,
-0.027262487,
-0.020546218,
-0.010392333,
0.0008374637,
-0.010524804,
0.009200096,
0.019459957,
0.0076501877,
0.02067869,
0.012352901,
-0.012094582,
-0.0019257941,
0.0016227671,
0.00096952054,
0.024427613,
0.0099154385,
0.010875851,
0.0026543834,
-0.030176844,
-0.017154966,
0.0024921065,
0.009458414,
-0.007398493,
-0.019393723,
-0.013975668,
-0.016214425,
-0.024321636,
-0.012160818,
0.008961649,
-0.006772569,
0.01605546,
-0.0044311476,
-0.010134015,
-0.043291453,
0.010458568,
-0.004656348,
0.0008213188,
0.009034507,
-0.020003088,
-0.00016745135,
0.0045106304,
-0.007915129,
-0.0051531135,
0.0005050449,
-0.03200494,
-0.029329032,
0.0148234805,
0.0011905811,
0.0076104463,
-0.02988541,
0.00029681734,
-0.026136486,
-0.015300375,
-0.022387562,
-0.04678868,
-0.018439934,
-0.014094891,
0.034972288,
0.021619232,
0.021513255,
0.015432846,
0.021645727,
0.0063354154,
-0.00024196616,
0.0068156216,
-0.0027007482,
0.0056962436,
0.0036727525,
0.0285607,
0.000776196,
-0.009160355,
0.01020025,
-0.010703639,
0.0017171525,
0.011452099,
-0.003089881,
-0.018188238,
0.0154196,
-0.034627862,
-0.009955179,
0.016161436,
-0.022427304,
-0.016134942,
-0.033276662,
-0.009902191,
0.0015557038,
-0.0073786224,
0.015525576,
0.010597663,
0.025103213,
-0.024321636,
0.015075175,
-0.0023165827,
-0.017260943,
-0.003290243,
-0.011425605,
0.012452253,
0.02938202,
0.022798222,
-0.0005191199,
0.004043671,
0.00043094403,
-0.009021261,
-0.0016790672,
0.0030103985,
-0.042019732,
0.011081181,
-0.014293597,
-0.003977435,
0.008544366,
-0.025725827,
-0.021155585,
-0.04016514,
0.0076965527,
0.0077098,
-0.015313623,
0.008782813,
-0.010100897,
-0.0013545138,
0.01895657,
-0.003520411,
0.02144702,
-0.014200868,
0.024970742,
0.002599739,
0.0064314567,
-0.03873446,
0.0072064106,
-0.005060384,
0.026533898,
0.034760334,
0.058287144,
-0.010094274,
-0.0024606448,
0.0069149747,
0.024599824,
-0.012571477,
-0.017883556,
0.007689929,
0.010908969,
0.019804383,
-0.024599824,
-0.010677145,
-0.017486144,
0.012180689,
-0.0027901658,
-0.008736448,
-0.0017883555,
0.0018181615,
-0.017870309,
0.015088422,
-0.015830258,
0.0073653758,
0.0027802305,
-0.0046066716,
-0.018665133,
-0.032614306,
0.013882938,
-0.00270406,
0.0110348165,
0.030494774,
-0.011359369,
0.0056266966,
-0.000117153846,
0.002730554,
0.007100434,
-0.0018463115,
0.0025666214,
0.038972903,
0.0019771263,
-0.0031130633,
0.019685159,
-0.009372308,
-0.0039343825,
-0.03468085,
-0.012114453,
-0.023142645,
-0.031077646,
0.0052094134,
0.022520034,
0.017751085,
0.010134015,
0.016797295,
-0.025089966,
-0.026812086,
-0.025381401,
-0.024467353,
0.010730133,
-0.04511955,
0.0021658973,
-0.022043139,
0.010273109,
0.0009397146,
0.013101361,
-0.0078290235,
-0.0002860541,
0.022268338,
-0.007835647,
-0.0019738146,
-0.004802066,
0.014942705,
0.010955334,
0.0067361393,
-0.009359061,
-0.010014791,
0.0074249874,
-0.007987988,
-0.026096744,
-0.026441168,
-0.0059446264,
0.017936544,
0.020307772,
-0.0044973833,
0.04702713,
-0.008471507,
-0.010074403,
0.009518025,
-0.022731986,
0.032031436,
-0.026282202,
0.016664825,
0.030998163,
0.0064049624,
-0.007398493,
0.006017485,
-0.0038515881,
0.021049608,
0.0071799164,
-0.009014637,
-0.007100434,
0.0049113543,
-0.016929766,
-0.010889098,
-0.017963039,
0.005908197,
-0.022957187,
0.012439007,
0.0075574582,
-0.030892186,
-0.011478594,
-0.0072593987,
-0.00030820156,
0.0028845512,
-0.016360141,
-0.01673106,
-0.0018877087,
-0.018532662,
-0.018095508,
-0.0016500892,
-0.02466606,
0.01912878,
-0.011107675,
0.0026924687,
-0.025010483,
0.009610755,
-0.057704274,
-0.007173293,
-0.0077561643,
0.004358289,
0.0048947954,
0.025871543,
-0.026215969,
0.020625701,
0.0007223797,
0.00011539447,
-0.015989223,
-0.031845976,
0.0073388815,
-0.0077561643,
0.022930693,
0.005060384,
-0.020758172,
-0.014479057,
0.034018498,
-0.0007525996,
-0.003046828,
0.032216895,
-0.042019732,
0.016784048,
0.0043483535,
0.025593355,
-0.01659859,
0.019261252,
0.002601395,
-0.025513873,
0.005593579,
0.00023078894,
0.0022784974,
-0.013478902,
0.011313004,
-0.01020025,
0.024295142,
0.008146953,
-0.010107521,
-0.02996489,
-0.009061001,
-0.0008217328,
0.014359833,
0.016452871,
-0.0050040837,
0.016068706,
0.009279578,
-0.0012013444,
-0.02013556,
0.013829949,
-0.015856752,
-0.014624774,
0.010703639,
0.0062195035,
0.00003153943,
-0.00718654,
0.0019191705,
-0.008948402,
-0.006842116,
0.0063188565,
-0.008180071,
-0.010584416,
-0.0030683544,
-0.0046629715,
-0.008021106,
-0.008113835,
-0.010995075,
-0.025633097,
-0.00900139,
-0.013843196,
-0.0002757048,
-0.0020516412,
-0.0058949497,
-0.0034707345,
-0.0077230465,
-0.021725208,
0.00024341507,
-0.021778196,
0.0068156216,
0.011313004,
0.19955398,
-0.016943013,
0.012617842,
0.032163907,
0.021460267,
-0.004815313,
0.0033167372,
-0.000014062084,
-0.00943192,
0.0013114607,
0.022559775,
0.012637713,
0.013300067,
0.0025599978,
0.010279733,
-0.010134015,
-0.0070606926,
-0.0016318745,
-0.026414674,
-0.003709182,
0.01437308,
0.015975976,
0.01405515,
-0.006196321,
0.020784667,
0.025222437,
-0.034442402,
-0.009345814,
0.019526193,
0.0121541945,
-0.016386636,
0.01899631,
0.01029298,
0.015750777,
0.012180689,
-0.017380167,
-0.020321019,
-0.00021671392,
0.0129225245,
-0.0034078108,
-0.019738147,
-0.01222043,
-0.035555158,
-0.015790517,
0.0023033358,
0.01459828,
-0.01763186,
-0.0116640525,
-0.013578256,
-0.004474201,
-0.029037595,
0.0035402817,
0.026798839,
0.010259862,
0.0027967894,
-0.010326098,
0.023963965,
0.0143333385,
0.00062054285,
0.0025782126,
-0.015499081,
-0.0058850143,
-0.03997968,
0.02938202,
-0.025990767,
0.04098646,
-0.023924224,
0.00044460507,
-0.0089947665,
-0.0128297955,
0.029752938,
-0.007027575,
-0.015379858,
-0.010094274,
-0.018890334,
-0.008140329,
0.014041903,
0.0046331654,
0.034044992,
-0.0025964275,
-0.0019026116,
0.0023099594,
-0.030070867,
-0.0032720284,
-0.006580486,
-0.014929458,
0.0070606926,
0.0036992466,
-0.022387562,
-0.00044791683,
0.0069149747,
-0.004159583,
-0.017009249,
0.002902766,
0.02466606,
-0.009398802,
-0.0008999734,
-0.002992184,
0.010372463,
-0.0127834305,
-0.011054687,
0.079906374,
-0.0069745868,
0.016360141,
-0.017022496,
0.018386945,
-0.019022804,
0.0016782392,
0.0024556771,
0.011736912,
0.007974741,
-0.032084424,
-0.005391561,
-0.012670831,
-0.020215042,
0.026732603,
0.021817937,
-0.0120482175,
0.03224339,
-0.03277327,
-0.004063541,
-0.004669595,
-0.00022830511,
0.022281585,
-0.0019804381,
0.012207183,
-0.011849511,
-0.007676682,
-0.006153268,
-0.018333957,
0.006249309,
0.005964497,
0.0021178767,
0.03332965,
0.022480292,
0.022506787,
0.012041594,
0.0033299844,
-0.01845318,
0.012167442,
-0.0016376701,
-0.0121541945,
-0.018638639,
-0.018108755,
0.024202412,
-0.0044046533,
0.016307153,
0.01963217,
-0.0018678381,
-0.007716423,
0.004371536,
-0.020440241,
0.0074051167,
-0.026533898,
0.024056694,
-0.029276043,
-0.015313623,
-0.0308392,
-0.004358289,
-0.005504161,
-0.008392024,
0.022188855,
0.017989533,
-0.020056076,
-0.033170685,
0.002616298,
-0.16712514,
0.02485152,
0.01180977,
-0.0131675955,
0.038284056,
-0.011094428,
-0.009319319,
0.0005480979,
0.0042191944,
0.0027802305,
0.023566552,
-0.010120768,
-0.0037787291,
-0.01673106,
-0.0045470595,
0.007842271,
0.01581701,
0.042867545,
0.012637713,
0.022029892,
0.037436243,
-0.018930076,
0.0039376942,
-0.028454725,
0.022255091,
-0.0024689243,
-0.010690392,
-0.0047755716,
0.007961494,
0.0069613396,
-0.010524804,
-0.001019197,
0.01886384,
0.003748923,
-0.0019208264,
0.009537896,
-0.0133199375,
-0.009153731,
0.0075707054,
0.033568095,
0.025089966,
0.028719665,
-0.008935154,
-0.010061156,
-0.044642653,
0.01763186,
0.006424833,
-0.0011831297,
0.034018498,
-0.017247695,
0.005494226,
-0.026798839,
-0.00155322,
0.018347204,
0.013432537,
0.01931424,
-0.010432074,
-0.017088732,
-0.000661526,
0.011008322,
-0.01063078,
-0.014704257,
0.022718739,
0.0120018525,
0.015565317,
-0.024149423,
-0.0072262813,
0.00847813,
-0.017194707,
0.018638639,
-0.0067825043,
-0.023314858,
0.020056076,
-0.022837963,
0.017512638,
0.0089947665,
-0.008166824,
0.02266575,
0.0076568113,
0.02320888,
-0.011167287,
0.008835801,
-0.010511557,
-0.025858296,
-0.011286511,
0.018426687,
0.007987988,
0.014518797,
-0.0048947954,
0.0016120039,
0.02670611,
-0.037065323,
0.01998984,
-0.0099618025,
0.02339434,
0.007544211,
0.0012278386,
0.00503389,
-0.020188548,
0.004441083,
0.013160972,
-0.021764949,
-0.0018794292,
-0.0078224,
0.017088732,
0.0023198945,
-0.029752938,
0.00067891274,
0.025924532,
-0.0058121555,
0.007789282,
-0.016717812,
-0.001509339,
0.015525576,
-0.023142645,
0.018506167,
0.007961494,
-0.008524495,
-0.0055505256,
-0.030123856,
0.062420234,
0.008531119,
0.0019340734,
0.017923297,
-0.011385864,
-0.06061863,
-0.12770183,
-0.03078621,
0.028057313,
0.005288896,
-0.0039343825,
0.012068088,
-0.005030578,
0.01545934,
0.006193009,
0.023129398,
-0.02502373,
-0.00540812,
-0.0053551313,
-0.003450864,
0.019883864,
0.020744925,
0.008219812,
-0.0204005,
-0.00482856,
0.027183006,
-0.021394031,
-0.015008939,
0.007809153,
-0.0045603067,
0.009180225,
-0.012419136,
-0.031263106,
0.014452563,
0.014346586,
0.02938202,
0.030415291,
0.013280196,
0.020479983,
0.0037290526,
-0.032534823,
-0.01210783,
-0.009438544,
-0.028799148,
0.040774506,
-0.0020019647,
0.0032505018,
0.0043748477,
0.010120768,
-0.015631553,
0.0017005936,
-0.0011450443,
-0.020148806,
-0.0065374332,
0.0167708,
-0.019049298,
-0.0112798875,
-0.032322872,
-0.028004324,
-0.011293135,
0.022122622,
-0.0049246014,
0.008769566,
0.01682379,
-0.034336425,
0.010100897,
0.0055803317,
0.0020334264,
-0.018069014,
-0.009816085,
0.02779237,
-0.023222128,
-0.023142645,
-0.027580418,
0.03791314,
-0.0023182386,
0.010889098,
0.005573708,
-0.013008631,
0.001524242,
-0.021062855,
0.00030157802,
-0.012193936,
-0.017115226,
0.0033829727,
-0.034044992,
-0.017472897,
-0.01963217,
0.015949482,
0.0074382345,
0.02511646,
0.0057128025,
0.0008850704,
-0.0122469235,
0.017353673,
-0.0019721587,
0.0031428693,
0.042178698,
0.0085046245,
-0.019208264,
-0.0001449934,
0.006428145,
-0.016558848,
-0.005159737,
0.009531273,
0.017035743,
-0.015154658,
-0.029276043,
-0.06607643,
0.02530192,
-0.011862759,
0.007345505,
-0.0014530389,
-0.0113726165,
-0.0051696724,
-0.01832071,
0.0072262813,
-0.0043781595,
-0.017115226,
0.01618793,
0.0054677315,
0.018837346,
-0.011690547,
0.016399883,
0.032349367,
0.03319718,
0.03046828,
0.008193318,
-0.017207954,
-0.03091868,
-0.023195634,
0.016545601,
0.0038582115,
0.003782041,
-0.007246152,
0.0057459204,
-0.014902963,
0.0014166094,
0.011524959,
-0.023765258,
-0.03142207,
0.011405734,
-0.016373388,
-0.042682085,
-0.007140175,
0.04779546,
-0.001796635,
0.025540367,
-0.010716886,
-0.03844302,
-0.0027835423,
-0.0036628172,
0.004583489,
0.0036296993,
-0.024507094,
0.010153886,
0.008663589,
-0.032137413,
0.01203497,
0.007464729,
-0.01555207,
-0.035714123,
-0.035926078,
0.0204005,
0.0016484333,
0.00012615773,
-0.023924224,
-0.011425605,
0.012717195,
0.015512329,
0.012955642,
0.02983242,
0.018386945,
-0.0367209,
-0.019605676,
-0.0005224316,
0.034336425,
-0.007484599,
-0.015856752,
-0.0281103,
-0.004209259,
-0.005308767,
0.0010995074,
-0.0023679154,
-0.004682842,
-0.023593046,
-0.022122622,
0.01573753,
0.0037555466,
-0.0046066716,
-0.025606602,
-0.0050703194,
0.030627245,
0.0009239837,
-0.01587,
0.044510182,
0.009849203,
0.0054677315,
0.007961494,
0.01042545,
-0.0026030508,
-0.0024871388,
0.0029888721,
0.0417018,
-0.013439161,
-0.0026957805,
-0.007530964,
0.0048517426,
-0.017764332,
0.0017303996,
-0.021923915,
-0.0012154194,
0.0036528818,
0.0024126242,
-0.027580418,
-0.03748923,
-0.012803301,
-0.014876469,
0.011226899,
0.008948402,
0.01841344,
0.011551452,
-0.003864835,
-0.0054412372,
0.0053816256,
-0.010074403,
0.0034972287,
0.034442402,
-0.003550217,
-0.006365221,
0.015896494,
0.0049080425,
-0.003404499,
0.0077561643,
0.027183006,
-0.008511248,
0.022824716,
-0.024281895,
0.01532687,
0.029779432,
-0.030812705,
-0.009213343,
0.008358906,
0.012843043,
-0.010398956,
0.011816394,
-0.0017734526,
0.08017132,
0.023606293,
-0.022546528,
-0.017499391,
-0.004354977,
0.0049080425,
-0.0013238799,
0.027262487,
-0.029037595,
-0.03319718,
0.0029276044,
-0.035131253,
0.017923297,
-0.045675926,
-0.025686085,
0.0116773,
-0.012299912,
0.003795288,
0.002558342,
-0.024652813,
0.0076568113,
0.022705492,
-0.0087496955,
0.01845318,
-0.04379484,
0.004639789,
0.018810851,
-0.0046960893,
-0.0017370231,
-0.029408514,
-0.011067934,
0.014571786,
-0.045278512,
-0.0312896,
0.023871236,
0.003146181,
0.0035270345,
-0.036323488,
0.024334883,
0.01755238,
0.00051249634,
0.010922216,
-0.030415291,
-0.03505177,
0.006365221,
-0.022162361,
-0.015684541,
-0.006842116,
-0.030044373
] |
BACKGROUND In the year 2000, the organizational structure of the ICU in the Zaandam Medical Centre (ZMC) changed from an open to a closed format ICU. The objective of this study was to evaluate the effect of this organizational change on outcome in high risk surgical patients. METHODS The medical records of all consecutive high risk surgical patients admitted to the ICU from 1996 to 1998 (open format) and from 2003 to 2005 (closed format), were reviewed. High-risk patients were defined according to the Identification of Risk in Surgical patients (IRIS) score. Parameters studied were: mortality, morbidity | [
0.011313859,
-0.022356404,
0.016590947,
-0.034891184,
0.016970789,
0.02943774,
-0.0039001615,
0.023088956,
-0.016889395,
-0.00009209892,
-0.003103172,
0.024350572,
0.028271083,
0.0021603503,
-0.015668474,
0.011530912,
0.028542398,
0.0045581018,
-0.0052669137,
-0.008905934,
-0.031119896,
0.012453385,
-0.023631586,
-0.0017855957,
0.008281908,
0.011469866,
0.013423338,
-0.03380592,
0.0065115737,
-0.017581249,
0.0003658521,
0.0011293511,
-0.019168446,
0.0011573305,
-0.034212895,
0.0061113834,
0.013531865,
-0.005460226,
0.011931103,
-0.016211106,
0.019561853,
0.001997561,
0.0056772786,
0.008024158,
-0.004629322,
0.0069728103,
0.005904505,
0.0053211767,
-0.021257576,
0.027307913,
0.022234311,
0.017364196,
0.0037034575,
0.0061588637,
-0.00047310654,
-0.01410841,
0.009238295,
0.006999942,
0.004476707,
-0.027755583,
0.021026958,
-0.012901056,
-0.026941637,
0.04020897,
0.0009131465,
-0.000019222602,
-0.004402095,
-0.0048260256,
0.010248946,
0.009645268,
0.045526754,
0.049216647,
-0.0067388006,
0.020104485,
0.031608265,
0.016780868,
-0.015559948,
-0.012738266,
0.015736304,
0.0004366485,
-0.0010428693,
-0.016373895,
-0.0074950927,
0.008064856,
0.014759568,
-0.01054061,
0.0036966747,
0.02253276,
0.004446184,
0.0034830137,
0.00015886799,
0.026453268,
0.01992813,
0.011496997,
-0.011612306,
0.0027267216,
-0.016265368,
0.013016365,
0.036654733,
0.0017855957,
-0.01828667,
-0.002974297,
-0.024228482,
-0.020660682,
-0.012331293,
-0.016618079,
0.015112277,
-0.004402095,
0.026371874,
-0.010248946,
-0.0024587973,
0.05697627,
-0.012778964,
-0.0138710085,
0.021135483,
-0.004948118,
0.0041443454,
0.0102692945,
-0.007291606,
-0.03174392,
-0.00014456033,
0.0012963797,
0.025802111,
-0.019900998,
0.025557928,
0.0033253115,
-0.019480458,
-0.02577498,
0.009794492,
-0.019480458,
0.0008008049,
-0.0042189574,
0.042243835,
0.044495754,
0.0018602074,
0.03277492,
-0.0032727441,
0.008024158,
-0.03396871,
-0.051658485,
-0.0114563005,
0.005636581,
-0.010710183,
-0.013491167,
-0.012480516,
0.0014693434,
0.02368585,
0.012955318,
0.013213068,
0.005087167,
0.00021726443,
-0.051685616,
-0.012785747,
0.006162255,
0.02690094,
0.018598683,
0.008844888,
0.016468855,
-0.04373607,
-0.019561853,
-0.024540493,
0.0064030476,
-0.019046353,
0.015288632,
0.011842925,
0.0044088783,
0.017147144,
0.0066472315,
0.01532933,
0.0005146517,
-0.004415661,
0.005623015,
-0.01931767,
0.0058163274,
0.016604513,
0.032666396,
-0.0040086876,
0.02317035,
-0.03901518,
-0.029844712,
-0.04341049,
0.0063487845,
0.021800207,
0.025598625,
-0.028732318,
-0.012202418,
0.030550133,
0.02737574,
0.0046801935,
-0.00824121,
0.021203313,
0.016889395,
-0.02946487,
0.01002511,
-0.6450799,
-0.017852565,
0.003957816,
-0.0016957223,
0.007834237,
0.017839,
0.011212116,
-0.0054568346,
-0.013660739,
0.011191768,
0.0011318946,
0.025815677,
0.024771111,
-0.02821682,
-0.007779974,
-0.017269237,
0.016509553,
0.0064335708,
0.009652051,
-0.016468855,
-0.0062131267,
0.027592793,
-0.0023790984,
-0.0031286078,
0.004222349,
0.023360271,
0.037197366,
-0.031201292,
0.0041545196,
-0.0087838415,
-0.01880217,
0.0071423827,
0.009333256,
-0.00957744,
0.042650808,
-0.018883564,
-0.024119955,
0.009991196,
0.012148155,
0.021203313,
-0.007216994,
-0.013491167,
0.025978466,
-0.0035406682,
-0.020647116,
0.0066404487,
0.004147737,
-0.020457195,
0.010906886,
-0.0033795745,
-0.0070677707,
-0.012148155,
-0.008404,
0.005012555,
0.008478612,
-0.008132684,
0.026765281,
-0.029736187,
0.019426195,
0.0024452317,
-0.01471887,
-0.012405905,
-0.03695318,
-0.024513362,
0.011286728,
-0.0023400967,
0.005195693,
-0.0014727348,
0.0006562445,
-0.006467485,
0.008275125,
0.0016287413,
-0.004514013,
0.013023147,
0.036736127,
0.028813714,
-0.001612632,
0.007610402,
0.0022943122,
0.012351641,
0.012928187,
0.0014973228,
-0.005924854,
-0.0013184241,
-0.0060808603,
0.0017923785,
-0.01023538,
0.001111546,
-0.007054205,
-0.006040163,
0.0070202905,
0.011218899,
0.011354557,
-0.014162673,
0.0029420783,
0.024255613,
-0.015614212,
0.00063165656,
0.039422154,
-0.01354543,
-0.03782139,
-0.009597789,
-0.011001847,
0.0003925597,
0.016129712,
0.018937826,
-0.006216518,
0.006162255,
0.061588634,
-0.04007331,
0.007902066,
-0.0023858813,
-0.0015795653,
-0.018625814,
0.022437798,
-0.02709086,
0.020416496,
0.024866072,
-0.011442734,
-0.022885468,
0.029085029,
-0.0101946825,
0.020009523,
-0.0013430121,
0.016238237,
0.011300294,
0.015966922,
-0.016319633,
-0.016970789,
-0.018747905,
0.023875771,
-0.013416555,
0.032585,
-0.020742076,
0.0077528427,
-0.0023350096,
0.002925121,
-0.0072848233,
0.0054127458,
-0.019968826,
-0.016021185,
-0.014908791,
0.000063589585,
-0.018652946,
-0.01880217,
-0.023862205,
0.0056399726,
0.017784735,
0.014868094,
-0.0068575013,
-0.012154938,
-0.026955202,
-0.0032591783,
0.0006074925,
-0.0069049816,
-0.011842925,
0.0034423163,
-0.025788546,
-0.014162673,
-0.023102522,
0.019534722,
0.038228363,
-0.023211047,
-0.0067557576,
0.0056467555,
-0.014854528,
-0.009048374,
0.0016389156,
-0.027484268,
-0.029003635,
0.015017317,
-0.011320642,
0.01298245,
-0.0044190525,
-0.00077324937,
0.015885526,
-0.013063845,
-0.026683887,
-0.0026300654,
-0.012114241,
0.024418402,
0.004059559,
-0.0048022857,
0.0030370387,
0.0119718,
0.012656871,
0.0048938547,
0.0042426973,
0.0019009047,
0.023740113,
-0.00006433146,
-0.0019721251,
0.00624365,
0.01863938,
-0.006932113,
-0.0034660564,
0.0070677707,
-0.009245078,
-0.004151128,
0.013782831,
0.029356346,
0.017391328,
0.02298043,
0.009896236,
0.008295474,
0.008058073,
0.027009465,
-0.00007355196,
0.03586792,
-0.005338134,
-0.0035677997,
0.009068723,
0.014854528,
-0.005870591,
-0.006460702,
0.02725365,
0.007847803,
-0.005650147,
-0.007006725,
0.02159672,
0.010248946,
0.0015710867,
0.03277492,
0.008363303,
0.0045547104,
-0.013877791,
0.017106447,
0.0010911974,
0.012249898,
-0.011069675,
-0.009672401,
0.025327308,
0.007644316,
0.017404893,
0.024554059,
0.033209026,
0.007949546,
-0.019276971,
0.032340817,
0.012955318,
0.0093400385,
0.027918372,
0.02201726,
-0.014935923,
0.015424291,
-0.033181895,
0.019575419,
0.017309934,
-0.013606476,
-0.026304046,
-0.0052838707,
-0.012656871,
-0.017242104,
-0.009353604,
0.0044190525,
0.004758197,
-0.0063284356,
0.0024689718,
0.026670322,
0.0177983,
0.0016736779,
-0.0006918547,
0.0055721435,
0.0032591783,
-0.016753737,
0.010208248,
-0.0008580355,
-0.004629322,
-0.0026046296,
-0.0033609217,
0.0053517,
-0.0057993704,
0.0075561386,
0.012012497,
0.0027046772,
0.016251802,
-0.0043071345,
0.004185043,
0.008390434,
0.013138456,
0.010927235,
-0.014908791,
-0.0032506997,
0.029085029,
0.006358959,
-0.011890405,
-0.0066031427,
0.023645151,
-0.014596778,
0.033209026,
-0.014990185,
-0.020294406,
-0.021311838,
-0.012548345,
0.0052567394,
0.014868094,
0.00819373,
-0.03467413,
-0.0064166132,
-0.0060842517,
-0.010513479,
-0.020104485,
-0.018381631,
-0.02586994,
0.027945504,
0.0010360864,
-0.008797407,
-0.01786613,
-0.012670437,
-0.012446602,
-0.018720774,
-0.01690296,
-0.02448623,
0.006423396,
0.015275067,
-0.012765397,
-0.012514431,
-0.00687785,
0.010337124,
0.0045343614,
0.008024158,
-0.0047242823,
-0.009692749,
-0.007908849,
0.047181778,
0.023767244,
-0.005216042,
0.021990128,
0.00809877,
-0.01002511,
-0.011653004,
-0.029247819,
-0.009875887,
0.021583155,
-0.0015100407,
0.013762482,
0.03570513,
-0.0060299886,
0.0051346472,
0.019873865,
-0.0032286553,
-0.013280897,
0.014230502,
-0.010934018,
0.0077121453,
0.008838105,
0.026019163,
0.03307337,
0.020036655,
-0.014664607,
0.015492119,
0.029654792,
0.002485929,
-0.022736246,
-0.014773133,
0.027674189,
-0.0041918256,
0.02317035,
-0.0071830796,
-0.0041545196,
0.011022195,
-0.015994053,
0.012656871,
-0.00043007758,
0.0021586546,
0.008268342,
0.013111325,
-0.014759568,
0.016726606,
-0.010995064,
0.013253766,
0.013715003,
-0.004965075,
-0.02589707,
0.020850603,
-0.023129653,
-0.015532817,
-0.02805403,
0.025883505,
0.026168387,
-0.013246983,
-0.011591958,
-0.013057062,
0.018300235,
-0.0111239385,
-0.016563816,
0.018937826,
-0.01828667,
-0.030712923,
-0.019521156,
-0.030794317,
-0.005443269,
-0.034836918,
-0.0055924924,
0.02368585,
-0.024920335,
-0.041674074,
0.01655025,
-0.0043342663,
-0.008295474,
0.027999768,
-0.0045818416,
0.023346705,
0.015017317,
0.00006835881,
0.003822158,
-0.009787709,
-0.02570715,
-0.0048362003,
0.011632655,
-0.017133579,
-0.03147261,
-0.020267274,
0.028840845,
-0.0076782308,
0.012026063,
-0.003476231,
0.021121917,
0.015112277,
-0.0025266262,
0.006803238,
0.009380736,
-0.0060672946,
-0.03377879,
0.005087167,
-0.014610344,
-0.010723748,
-0.00055195764,
0.0021603503,
-0.007983461,
-0.010092939,
0.019019222,
0.012772181,
-0.009272209,
0.022776943,
-0.017744038,
-0.000781728,
-0.009021243,
0.020199444,
0.00445975,
-0.005277088,
0.026168387,
0.03082145,
-0.035813656,
0.009780927,
0.0047378484,
0.025856374,
-0.0026521098,
-0.017459158,
0.0047480226,
-0.016862262,
-0.012222767,
-0.050627485,
-0.0137217855,
-0.015858395,
0.0131655885,
0.0119039705,
-0.008553224,
-0.003303267,
-0.024350572,
0.0017109838,
0.023631586,
-0.013443687,
-0.022926167,
-0.018300235,
0.0061724293,
-0.013308029,
-0.024703283,
0.014203371,
-0.028135424,
-0.0109747145,
0.01767621,
-0.0003976469,
0.004805677,
0.002772506,
-0.0037271976,
-0.003462665,
-0.010662702,
-0.019711077,
-0.055321246,
-0.010581307,
-0.0039544245,
0.019968826,
0.033480342,
0.03518963,
-0.0076239677,
0.010906886,
0.019236274,
-0.0047276737,
0.0021857861,
0.012473733,
-0.0017126795,
-0.008973762,
0.031445473,
0.013118108,
0.00007037248,
-0.018096749,
-0.01246695,
0.008030941,
-0.002455406,
-0.005504315,
-0.017133579,
-0.016116146,
-0.039476417,
-0.005768847,
-0.007827454,
-0.0014998664,
-0.0061283405,
-0.052038327,
0.00031413257,
0.0054636174,
-0.0051753446,
0.015125844,
-0.0073255203,
0.02230214,
-0.0065013994,
0.0022587022,
-0.020809904,
0.008376868,
-0.0036356286,
0.023631586,
-0.03331755,
-0.005049861,
0.005378831,
-0.0012022671,
0.01258226,
0.02349593,
-0.024404837,
0.012107458,
0.0008152185,
-0.01786613,
0.011144287,
0.016306067,
-0.021542456,
-0.014094844,
-0.016753737,
0.0067082774,
-0.009943716,
-0.00080885954,
0.004032428,
0.0018788604,
0.018083183,
-0.024771111,
0.0048565487,
0.014840962,
-0.029302081,
0.028949372,
0.004914203,
0.028867977,
0.034402814,
-0.0077528427,
0.0048565487,
0.015044449,
0.00866175,
0.0038119839,
0.019697512,
0.018761473,
-0.0011632656,
0.0026470225,
0.0028742494,
0.015478553,
-0.014406857,
-0.020240141,
0.0034643607,
0.023509495,
-0.016156843,
-0.0280269,
-0.014094844,
-0.024893204,
0.022709114,
-0.002173916,
0.006552271,
0.0039544245,
-0.0162925,
-0.00212474,
0.023306008,
-0.03885239,
0.012195635,
0.016699474,
-0.0048260256,
0.01115107,
-0.03065866,
-0.0234281,
0.016767303,
-0.026114125,
-0.0026978943,
0.0032710484,
-0.0075697047,
0.007997027,
0.014881659,
-0.0031642178,
-0.009706315,
-0.03434855,
0.035678,
-0.011429168,
-0.0077664084,
0.031445473,
-0.003303267,
-0.02143393,
-0.017391328,
0.0001581261,
0.00008017587,
-0.015302198,
-0.00012569541,
0.0021790033,
0.01735063,
0.0036966747,
-0.0016050012,
-0.005331351,
-0.005857025,
0.0030183857,
-0.012941753,
-0.013409772,
-0.043925993,
-0.030767186,
0.010472781,
-0.00664384,
0.012663654,
-0.020104485,
-0.0030997805,
-0.0053483085,
0.030902844,
-0.051631354,
0.014732435,
0.018490156,
-0.0043444405,
-0.013796397,
0.005307611,
-0.020362234,
-0.008682098,
0.02345523,
-0.008200513,
-0.020755641,
0.0055551864,
-0.0074950927,
0.013959186,
-0.015193672,
0.018245973,
0.003493188,
0.019114181,
-0.0006019814,
0.0030065158,
-0.013253766,
0.037034575,
-0.033860184,
-0.002821682,
0.020023089,
-0.02706373,
0.018137446,
-0.006233475,
0.035433814,
-0.0013048584,
-0.023224613,
-0.011042544,
-0.0059519853,
0.019887432,
-0.037685733,
0.00922473,
-0.0071423827,
0.0005133799,
-0.0155056855,
0.009957282,
0.02856953,
-0.008390434,
-0.012405905,
-0.034592737,
0.0057925875,
0.023984296,
0.0021874818,
-0.013640391,
0.020226575,
-0.0071220337,
-0.034022972,
-0.02349593,
-0.024404837,
0.032693528,
0.0071288166,
-0.016658776,
-0.044522885,
-0.00033257355,
-0.053286377,
0.017052183,
-0.0041918256,
0.037767127,
0.026507532,
0.0132402005,
0.01950759,
0.021352535,
0.009862321,
0.012799312,
-0.022519194,
-0.017581249,
0.011435951,
-0.003822158,
0.042270966,
-0.007169514,
-0.042243835,
-0.011137504,
0.01828667,
0.006060512,
0.0024638847,
0.025286611,
0.009536742,
-0.014162673,
0.018259538,
-0.0058638076,
-0.020036655,
-0.01136134,
0.006287738,
-0.036980312,
-0.0061283405,
0.015736304,
-0.013701436,
0.025123822,
0.006932113,
-0.0027758975,
0.0254494,
-0.0022146134,
0.016536685,
-0.009753795,
0.016699474,
-0.015994053,
-0.0020619985,
0.012873924,
0.017594814,
0.00896698,
0.01943976,
-0.0051889103,
-0.005260131,
0.0051923017,
-0.008810974,
-0.020999825,
0.016563816,
-0.012148155,
-0.022709114,
-0.0087838415,
0.012222767,
-0.027172254,
-0.011836142,
-0.009685966,
0.0016380678,
-0.012589043,
-0.008749927,
-0.015532817,
-0.020837037,
-0.0007846955,
-0.022220746,
-0.017242104,
0.005765456,
-0.016495988,
0.000081447666,
-0.015166541,
-0.021094786,
-0.015464988,
-0.020687813,
0.011279945,
0.0015863483,
-0.0026368483,
-0.010296426,
0.023373837,
0.19480458,
0.0013879488,
-0.016238237,
0.015044449,
-0.034918316,
0.0029827757,
0.006297913,
0.0048192427,
0.004469924,
0.027809847,
0.010486347,
0.008383651,
0.00007302204,
-0.004965075,
0.025110256,
-0.011442734,
-0.016251802,
-0.019588985,
0.0018178143,
0.020063786,
-0.0014159281,
-0.0031862622,
-0.0012777267,
0.013708219,
0.027212951,
-0.007732494,
-0.0014617126,
0.01793396,
0.032802053,
0.029247819,
-0.005887548,
-0.012059977,
0.005110907,
0.01328768,
0.012222767,
-0.010106505,
-0.00011732279,
-0.025395138,
0.0028081161,
-0.009516394,
-0.02378081,
0.014881659,
-0.00063716766,
-0.005575535,
-0.008030941,
0.028189689,
-0.004514013,
-0.008139467,
-0.022790508,
-0.0016143277,
-0.017432027,
-0.0019687337,
0.006423396,
-0.0010047155,
0.017282803,
0.007169514,
0.026168387,
-0.009448565,
0.0061724293,
-0.020145182,
-0.0008470133,
-0.011958234,
-0.0055484036,
0.0059655514,
-0.007922415,
0.025734283,
-0.01889713,
-0.003676326,
-0.010811926,
-0.012894273,
0.010479564,
-0.021474628,
-0.024323441,
0.0026131081,
-0.023740113,
-0.0072034285,
0.034240026,
0.018815735,
0.01410841,
0.014610344,
-0.008838105,
-0.015275067,
0.0012429645,
0.0042630457,
-0.026209084,
-0.029573398,
0.032232292,
0.015912658,
-0.023889337,
0.007047422,
-0.0111239385,
-0.007237343,
-0.011639439,
-0.002016214,
0.007854586,
0.014746002,
0.020769207,
0.023957165,
-0.00082793646,
0.0061893864,
-0.016224671,
0.05784448,
0.03082145,
-0.021976562,
-0.00038916827,
-0.005497532,
-0.016563816,
0.035298157,
0.0066574058,
-0.04042602,
0.025951335,
-0.01002511,
0.0008953414,
-0.015003751,
0.01014042,
0.021827338,
0.0033829662,
-0.020972693,
0.015492119,
-0.012100674,
-0.008736362,
-0.003930684,
0.0030489087,
0.009563874,
-0.012053194,
-0.0055653607,
-0.012561911,
-0.013436904,
-0.006399656,
-0.029817581,
-0.0004341049,
-0.022926167,
0.00026983183,
-0.000034391367,
-0.0009903018,
-0.0013777744,
0.007481527,
-0.026711019,
0.005039687,
0.019466892,
-0.005734933,
-0.008505743,
0.0011776792,
-0.01140882,
0.01446112,
-0.010452433,
0.031662527,
-0.006735409,
-0.018571552,
-0.015288632,
0.010615222,
-0.023875771,
0.008492177,
-0.016590947,
0.02361802,
-0.024594758,
-0.006179212,
-0.013796397,
-0.0022773552,
0.015112277,
-0.022112219,
0.0019314277,
0.030712923,
-0.01446112,
-0.0162925,
0.011700484,
-0.17288229,
0.024635455,
0.029247819,
0.003279527,
0.043953124,
-0.0028912066,
0.009780927,
0.017269237,
-0.021718811,
-0.007610402,
0.00041608786,
0.0062199095,
-0.03991052,
-0.021664549,
-0.0053449166,
0.028705187,
-0.028786583,
0.017635513,
0.008729579,
0.015953356,
0.015492119,
-0.007854586,
0.008336171,
-0.011686918,
0.01751342,
0.014773133,
-0.02213935,
0.021325404,
-0.00150241,
-0.01699792,
-0.013219851,
-0.017011486,
0.029247819,
-0.013572562,
-0.024242047,
0.004303743,
-0.012100674,
0.0066302745,
-0.013932055,
0.012263464,
0.008716013,
0.032530736,
-0.0127586145,
0.0056535383,
-0.024703283,
0.010520262,
0.03782139,
0.0020857386,
0.007949546,
-0.0054466603,
-0.02105409,
-0.006016423,
0.016740171,
-0.0071830796,
0.004188434,
-0.0006252976,
-0.008702447,
0.0034609693,
-0.00024715153,
0.0012692482,
-0.005541621,
-0.029709056,
0.0014684956,
0.024621889,
-0.011944668,
-0.031418342,
0.015437856,
-0.005504315,
-0.016943658,
0.016156843,
-0.027524965,
0.03030595,
0.009909801,
-0.014352594,
0.029736187,
0.0331005,
-0.010262512,
0.0010776315,
0.014786699,
-0.01699792,
0.00006915368,
0.015003751,
-0.02603273,
-0.020172313,
0.0074001323,
0.01176153,
0.00067192997,
-0.003584757,
-0.002173916,
-0.012046412,
0.013267332,
-0.030441608,
0.0036118885,
-0.0101879,
0.001911079,
0.024187783,
-0.0148002645,
-0.014040581,
0.0021281315,
-0.044577148,
0.007651099,
0.014759568,
-0.019778905,
-0.0017186146,
0.005667104,
0.02345523,
-0.004018862,
-0.0019568636,
0.046557754,
-0.016970789,
-0.0020925214,
0.01100863,
0.004795503,
0.00481246,
-0.00065497274,
0.0019009047,
0.0030336473,
-0.023414534,
-0.0009979326,
-0.022166483,
0.036302023,
-0.0109408,
-0.026480401,
-0.0031540436,
-0.018164577,
-0.009794492,
-0.12317727,
-0.0014888442,
0.014881659,
-0.000677865,
-0.005958768,
-0.00031900776,
-0.016943658,
0.009794492,
-0.015370027,
0.030387344,
-0.016536685,
-0.028542398,
-0.03521676,
-0.00008044083,
0.034050103,
0.000580361,
-0.008302256,
-0.030984238,
0.012704352,
0.018435894,
0.0034219676,
0.000045122113,
0.010330341,
-0.0071559483,
0.01638746,
-0.02159672,
-0.02911216,
0.029519135,
0.0003700914,
0.034538474,
0.0053211767,
0.0037000661,
-0.0015804132,
-0.023088956,
-0.026114125,
-0.0062368666,
-0.015587079,
-0.010228598,
0.031011371,
-0.02500173,
0.016373895,
0.0067082774,
0.027484268,
-0.016808,
0.01800179,
0.009421433,
-0.036139235,
0.010757662,
-0.014678173,
-0.020931996,
-0.016129712,
-0.020769207,
0.0017296368,
-0.0055246633,
0.028678056,
-0.026019163,
0.018435894,
0.012087109,
-0.014786699,
-0.0011632656,
-0.00040188618,
0.01889713,
-0.03063153,
0.034619868,
0.017201407,
-0.03727876,
-0.0060299886,
-0.013226634,
-0.008587138,
-0.009346821,
-0.0101946825,
0.017839,
-0.033019107,
-0.014637475,
-0.027945504,
-0.025476532,
-0.028732318,
-0.006087643,
-0.009760578,
-0.023930034,
-0.0003243069,
-0.01863938,
0.021284707,
-0.008763493,
0.009950499,
0.018205276,
0.005076993,
-0.017296368,
0.018435894,
0.006114775,
0.037143104,
0.026046295,
-0.01671304,
-0.041402757,
0.01828667,
-0.004887072,
0.004059559,
-0.03600358,
-0.020592852,
0.020294406,
-0.017635513,
0.0027691147,
-0.052363906,
0.029247819,
-0.0019144706,
-0.0108254915,
0.0007524768,
-0.012154938,
0.011035761,
0.0053110025,
0.015654908,
0.023224613,
-0.03814697,
0.02413352,
-0.020782772,
0.0066167084,
-0.01896496,
-0.021149049,
0.0016830044,
0.030740054,
0.027240084,
0.006915156,
-0.010832274,
-0.013199503,
0.011720832,
0.018408762,
0.012962102,
0.0006342002,
0.013382641,
0.012521214,
-0.006742192,
-0.008831322,
0.023631586,
-0.010744097,
-0.015885526,
0.020837037,
-0.005222825,
-0.0234281,
0.009570657,
0.020335102,
0.025327308,
0.0035101452,
-0.025571493,
-0.027362175,
-0.0015609125,
0.0044800984,
-0.013823529,
0.007413698,
-0.01812388,
0.016061882,
-0.024852507,
-0.013816746,
0.03063153,
0.007976678,
-0.023835072,
-0.024920335,
0.008017375,
0.016509553,
0.015125844,
0.012514431,
-0.023577323,
-0.012589043,
0.035840787,
-0.011992148,
0.012100674,
0.0066913203,
0.016685909,
-0.011849708,
-0.021121917,
0.012548345,
0.015831264,
-0.013525082,
-0.022627719,
-0.019846734,
-0.00031180095,
0.018340932,
-0.023197481,
-0.0033015714,
0.001233638,
0.03798418,
0.0020484326,
0.014149107,
0.018937826,
0.004347832,
0.0033677046,
0.00047056295,
0.041022915,
-0.0018771646,
0.010499912,
0.02561219,
-0.00048328086,
0.0077664084,
-0.009122986,
0.025666453,
-0.009421433,
0.0005833285,
0.0046089734,
0.029193556,
0.017309934,
-0.013382641,
0.011883622,
0.008370086,
0.0035033624,
0.022275008,
-0.005222825,
-0.042216703,
-0.016021185,
-0.015736304,
-0.0065658367,
-0.06397621,
-0.0091569,
0.021162614,
0.005131256,
0.008519309,
0.023645151,
0.0076239677,
-0.024079258,
-0.0017381154,
0.0009733446,
-0.010872971,
-0.011619089,
0.006840544,
-0.006803238,
0.012616174,
-0.0030523003,
0.0044733156,
0.00396799,
0.0045581018,
0.026778847,
-0.04688333,
0.02605986,
-0.000378782,
0.016428158,
0.019304102,
-0.012358424,
-0.02384864,
0.005843459,
-0.020131616,
0.0016228063,
0.0029319038,
0.0048395917,
0.08692951,
0.008234427,
-0.0059655514,
0.0055280547,
-0.026928071,
-0.0023010953,
0.0016278934,
0.018205276,
-0.0028606835,
-0.022790508,
0.019534722,
-0.006277564,
0.0036322372,
-0.021230444,
0.0016270456,
-0.0037950266,
-0.006687929,
0.03432142,
0.018693643,
-0.013891357,
-0.002479146,
-0.018761473,
0.018300235,
0.020592852,
-0.031065634,
-0.011768313,
0.0007872391,
-0.006114775,
-0.0148002645,
-0.03329042,
0.0016117841,
-0.0013599693,
-0.01574987,
-0.025462966,
-0.0026283697,
-0.016848696,
-0.017730473,
-0.014366159,
0.012772181,
0.0025317133,
-0.018883564,
0.032639265,
-0.030604396,
-0.030685792,
-0.04012757,
-0.038988046,
-0.003138782,
-0.010384603,
-0.02561219
] |
CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain challenging. Reportedly, mesenchymal stem cells (MSCs) have successfully treated graft-vs-host disease. OBJECTIVE To assess autologous MSCs as replacement of antibody induction for patients with end-stage renal disease who undergo ABO-compatible, cross-match-negative kidney transplants from a living-related donor. DESIGN, SETTING, AND PATIENTS One hundred fifty-nine patients were enrolled in this single-site, prospective, open-label, randomized study from February | [
-0.008234407,
0.010008597,
0.0038497208,
-0.010678997,
-0.012710512,
0.031258244,
-0.016238576,
-0.0023904159,
-0.026734736,
0.0012637716,
0.01542597,
0.0058846218,
0.007828104,
0.004824848,
-0.016577162,
0.0018757655,
0.030310202,
0.004994141,
0.00090741,
0.0065347063,
-0.035131663,
0.012622479,
-0.007963538,
-0.009676782,
-0.006754787,
0.00040418684,
0.015927076,
-0.036269315,
-0.001960412,
-0.0093923705,
0.0049399673,
-0.0061013163,
-0.014030997,
0.0015160181,
-0.009385599,
0.0019316322,
0.0033570784,
-0.008830318,
0.022184143,
0.009290795,
0.026802454,
-0.0041172034,
-0.0048146904,
-0.0006200353,
0.01621149,
0.002793333,
-0.007550464,
-0.014802972,
-0.014098713,
0.008369842,
0.03266676,
-0.008952209,
-0.016346924,
0.017213704,
-0.01996302,
-0.019705694,
0.0011647352,
0.03128533,
0.015317623,
-0.020843344,
0.006659983,
0.011620265,
-0.019272305,
-0.0020010422,
-0.012520904,
0.006118246,
-0.018202374,
-0.015588491,
-0.010211748,
-0.013448629,
0.02998516,
0.009209534,
-0.020613104,
-0.021019408,
0.03561923,
-0.011897906,
-0.007943223,
0.014857146,
0.00477406,
0.0039512967,
0.004401616,
-0.023511399,
-0.0049805976,
0.033316843,
0.0071509327,
0.012690197,
0.0021618705,
0.011390027,
0.00090317766,
-0.016319837,
0.013319966,
0.03881548,
-0.00008205416,
-0.0021449411,
-0.006758173,
0.033154324,
0.02118193,
0.01759292,
-0.010340411,
-0.01538534,
-0.0026426623,
0.007144161,
0.00080752716,
-0.030553985,
-0.039546825,
-0.00554265,
0.007841648,
-0.009717413,
0.02769632,
0.014681081,
-0.02868499,
0.042770162,
-0.008566221,
-0.02635552,
0.008911579,
-0.008234407,
0.029118381,
0.0014330645,
0.0024496685,
-0.02575961,
-0.0018317493,
0.007238965,
0.015155101,
-0.021073582,
0.029605944,
0.012737598,
-0.03941139,
0.0029693977,
-0.025813783,
0.01073317,
0.003079438,
0.020572474,
0.0057965894,
0.032043763,
-0.007740072,
0.00954812,
-0.018568046,
-0.014464387,
-0.032531325,
-0.032883454,
-0.00668707,
0.032043763,
0.00018082598,
0.009493946,
-0.02264462,
-0.006328169,
0.006659983,
0.00038069743,
0.0069816397,
0.0025106138,
-0.0069816397,
-0.015656209,
0.0018063553,
-0.008552678,
-0.00506863,
-0.002536008,
-0.0004287343,
0.023958333,
-0.016482357,
-0.012121373,
-0.017877331,
-0.022658164,
0.027587973,
-0.00026917574,
0.016536532,
0.011064985,
-0.0017572604,
0.0061927345,
-0.0011401877,
-0.021290276,
0.006179191,
0.047781233,
-0.010550334,
0.024635505,
0.0014694624,
0.0015244826,
-0.004963668,
0.014179974,
-0.03553797,
-0.008742286,
-0.013719497,
0.015507231,
0.0105435625,
0.006710771,
-0.0005658615,
0.00079567666,
0.024865743,
-0.003319834,
-0.0059523387,
-0.020030737,
-0.008911579,
0.016279206,
-0.0010411514,
-0.019150414,
-0.6357829,
-0.03247715,
0.013672096,
0.003394323,
0.04044069,
0.030987374,
0.022929031,
-0.010692541,
-0.01594062,
0.01447793,
-0.011884362,
0.02355203,
0.009907021,
-0.011532233,
-0.0041646054,
-0.018134657,
-0.0052514663,
-0.022671707,
0.030066421,
0.002769632,
-0.0024699837,
0.0022752967,
-0.014532103,
0.014830059,
-0.0021398624,
-0.017931506,
0.02332179,
0.016780313,
-0.0032639673,
0.020193258,
-0.026220087,
0.027642146,
-0.012602164,
0.013590835,
0.056936592,
0.010313324,
-0.017010551,
0.024838656,
-0.025529372,
0.023416596,
-0.019421283,
-0.018784741,
0.030879026,
-0.0026917574,
-0.010225292,
0.021980992,
0.016008338,
-0.0028729008,
-0.011660895,
-0.002004428,
0.03049981,
0.01858159,
-0.03255841,
0.0069613247,
0.015046754,
-0.0038564925,
0.031068634,
-0.002216044,
0.03415654,
0.012060427,
0.0065143914,
0.014098713,
-0.009053784,
-0.0437182,
0.00745566,
0.00020167018,
-0.02773695,
0.008633939,
0.024053136,
-0.00009877183,
0.020775625,
0.010936322,
-0.01021852,
0.0010716241,
0.0084037,
0.019556718,
-0.0010352262,
-0.013868475,
-0.021588232,
0.0005810979,
-0.0015185574,
0.00043592925,
-0.0027103794,
-0.0017623391,
0.03077068,
0.008925122,
-0.018486787,
0.0117692435,
-0.0030184926,
0.017145986,
-0.001863915,
0.014775885,
-0.01621149,
-0.06051206,
-0.0072254213,
0.032720935,
-0.015669752,
0.005400444,
0.013049098,
-0.026287803,
-0.01013726,
-0.0079567665,
0.015128015,
-0.008654254,
-0.0015676523,
-0.015561405,
-0.05953693,
0.010469073,
0.04071156,
-0.0426889,
-0.0069884113,
-0.0073269974,
0.010408129,
-0.020220345,
0.025664805,
-0.02450007,
-0.0024412037,
0.013651781,
0.003106525,
-0.01901498,
0.018202374,
-0.005806747,
0.0014821595,
0.0077197566,
0.0041950783,
-0.0054884763,
0.0014990887,
-0.008925122,
-0.0003485318,
-0.0053394986,
0.009236622,
-0.028847512,
0.013069413,
-0.015317623,
0.030797767,
-0.019001435,
0.004039329,
0.006615967,
-0.0024902988,
-0.027317105,
-0.025123067,
-0.014924863,
0.010509704,
0.0064399024,
-0.0110717565,
0.007740072,
-0.0040799594,
0.006277381,
0.00645006,
-0.011484831,
-0.002292226,
-0.0026731351,
0.009223077,
0.017132442,
-0.00027891007,
-0.013523118,
-0.0038801935,
-0.020504758,
-0.0011858968,
-0.014965493,
-0.0077942456,
0.030066421,
-0.0074421163,
0.009832532,
-0.020193258,
-0.02153406,
0.007943223,
0.009256937,
-0.009243393,
-0.031691633,
-0.0007660504,
-0.021276733,
-0.027845299,
0.019109784,
-0.012764686,
-0.025068894,
-0.028630817,
-0.0052819387,
-0.0031420765,
0.008735514,
0.0073269974,
-0.02458133,
0.0039072805,
-0.009649696,
0.024770938,
0.0038023188,
0.021994535,
-0.0006619353,
0.0032605815,
0.05168174,
-0.04019691,
0.005055086,
-0.01905561,
0.017579377,
0.0060268277,
-0.020017194,
-0.004902723,
0.0015989715,
0.0112410495,
0.0052209934,
0.014599821,
-0.0043846862,
0.03534836,
0.0024141169,
0.018947262,
-0.025746066,
-0.0016506059,
-0.0071847914,
0.032206282,
0.024391722,
-0.0019316322,
-0.011268136,
-0.0013704262,
-0.022658164,
0.017877331,
-0.0029507754,
-0.008661025,
-0.014152887,
-0.0044693328,
-0.000047904603,
-0.012656338,
0.015832273,
0.017836701,
-0.0061758053,
-0.014884233,
0.016157316,
0.0076520396,
0.016536532,
0.0013966665,
-0.008823547,
-0.0028339634,
0.02091106,
0.0045201206,
-0.014139344,
0.0027306946,
0.011301994,
0.015398883,
-0.0018554503,
0.027506713,
0.00005203112,
0.0029541613,
0.0017572604,
0.0012637716,
0.014220605,
0.0012070584,
-0.016522989,
0.015751012,
0.02493346,
0.018039852,
0.019773412,
-0.021683035,
-0.0044219308,
-0.023443682,
0.0056577693,
0.017335594,
-0.016157316,
-0.002957547,
0.024066681,
0.046264365,
0.025475197,
0.018906632,
0.017890874,
-0.0014025918,
-0.034129452,
0.011247821,
0.003394323,
0.027425451,
-0.005495248,
-0.014491473,
0.005881236,
-0.024974091,
-0.0077197566,
0.020030737,
-0.034400318,
0.0074421163,
0.0075369203,
0.0245407,
0.018689938,
0.009284023,
-0.0056408397,
0.0031640844,
-0.02146634,
0.024093768,
-0.0073676277,
-0.009121502,
-0.00016749417,
-0.023579117,
0.006131789,
-0.0208298,
0.013739813,
0.008329211,
0.0049535106,
0.023917703,
-0.002175414,
0.0022752967,
-0.03933013,
0.017796071,
-0.010428444,
0.0050787874,
-0.0103539545,
-0.0007791706,
-0.02402605,
-0.015304079,
-0.028332861,
0.020464128,
-0.0018097413,
-0.0065042335,
-0.03846335,
-0.014802972,
-0.018012766,
0.009839304,
-0.009026698,
0.0014550725,
-0.016387554,
0.0117692435,
0.0051939064,
-0.00017246716,
0.0039411387,
0.02066728,
0.002315927,
-0.002221123,
-0.022360208,
-0.0018114342,
-0.011687983,
0.019299392,
0.020139085,
-0.0070493566,
0.025001178,
0.0074895183,
0.019258762,
0.00015246942,
-0.050706614,
0.014694625,
-0.008816775,
-0.018568046,
-0.0034569611,
0.011342625,
0.010909235,
0.008532363,
0.031420764,
-0.008227635,
-0.008661025,
-0.005400444,
0.0005214222,
-0.0021787998,
-0.0069139223,
0.0443412,
0.025989847,
0.0010936322,
-0.009040241,
0.012873033,
0.012216177,
-0.0073879426,
-0.038246654,
-0.0013297958,
0.0020806098,
0.01317776,
0.0053462703,
0.0072321934,
-0.018080482,
0.015358252,
0.019705694,
0.01384816,
0.00788905,
0.032720935,
0.0043101977,
0.007069672,
0.00042026964,
0.0100898575,
-0.037217353,
0.010435215,
0.010164347,
-0.020409953,
-0.005630682,
0.028901685,
-0.018933719,
-0.01901498,
-0.026843084,
0.00477406,
0.015398883,
-0.032585498,
-0.00055147166,
0.0044524036,
-0.0053293407,
-0.0070290416,
-0.031935416,
0.00164722,
-0.014843603,
-0.03372315,
-0.013699182,
-0.020545388,
-0.0030388078,
-0.0066532115,
-0.0024445897,
-0.0070154984,
0.0016497595,
-0.004994141,
0.018811828,
0.007828104,
0.019475456,
0.028359948,
-0.018771198,
0.007983854,
0.036946487,
-0.0003396439,
-0.0041239755,
-0.00040863076,
-0.042499293,
0.0113358535,
-0.003150541,
0.0008498504,
0.0040528723,
-0.03239589,
0.014058083,
0.009446545,
0.005278553,
-0.006565179,
0.01822946,
0.0029219957,
-0.015100928,
0.016563619,
0.0049094944,
-0.028332861,
-0.024364635,
-0.0041104318,
-0.01996302,
-0.010015368,
-0.020613104,
-0.010516476,
-0.017200159,
-0.0036262542,
0.008071886,
0.011484831,
-0.021276733,
0.012432871,
-0.018798284,
-0.004824848,
-0.0071238456,
0.010604508,
0.008038027,
-0.0019333251,
0.013800758,
0.023687463,
0.012432871,
-0.0012180625,
0.0005561272,
0.020504758,
0.003341842,
-0.018446155,
-0.009006383,
0.0015236362,
-0.014166431,
-0.026951432,
-0.010855061,
-0.030120594,
0.039005086,
0.009670011,
-0.020193258,
-0.011159789,
-0.016265662,
0.01585936,
0.031231156,
0.025339764,
-0.018811828,
-0.016008338,
0.0042661815,
-0.0036160967,
-0.010563877,
0.0081463745,
-0.03759657,
-0.014071627,
0.013252249,
-0.0034671188,
-0.013489259,
0.0033841652,
0.0054241447,
-0.009480403,
0.006832662,
-0.011010811,
-0.032097936,
-0.0106180515,
-0.0094668595,
0.04209299,
0.03223337,
0.04382655,
-0.019786956,
0.0075572357,
0.012575078,
0.000776208,
0.0036127106,
-0.01736268,
0.03838209,
-0.012473501,
-0.0011731999,
0.01850033,
-0.010665453,
0.0104487585,
-0.019908845,
-0.0024564401,
0.010421672,
-0.014166431,
-0.028278688,
-0.01116656,
-0.038680043,
-0.011742156,
0.021953905,
0.010069543,
0.0034705047,
-0.030824853,
0.0035686945,
0.015872903,
0.006165648,
0.0039106663,
-0.010990496,
0.039275955,
-0.01227035,
0.0004693646,
-0.012283893,
-0.0022109654,
0.00093957566,
-0.004713115,
-0.0045946096,
-0.010320096,
0.01092955,
0.02505535,
0.0027391594,
0.026071109,
-0.0168074,
0.013936193,
0.009697098,
-0.03380441,
-0.021926818,
0.0072660516,
-0.03905926,
-0.000099829915,
-0.012852718,
-0.026341977,
-0.017931506,
-0.0071712476,
0.020111999,
-0.021019408,
0.0031590057,
-0.011403571,
-0.006927466,
0.02930799,
-0.021317363,
0.019299392,
-0.027764037,
-0.0012095978,
0.030906115,
-0.021385081,
-0.0149790365,
-0.013963279,
0.010028912,
0.0009810524,
0.029714292,
0.05574477,
-0.0020450584,
-0.01975987,
0.0030405007,
0.0108821485,
-0.02414794,
-0.044232853,
0.01707827,
0.019340022,
0.009974739,
-0.027547343,
-0.022780053,
-0.026409695,
0.013150673,
-0.008424016,
-0.022184143,
0.01120719,
0.0034434178,
-0.03179998,
0.014274778,
-0.0015693452,
-0.0062943106,
0.0039038945,
-0.021994535,
-0.021073582,
-0.019299392,
-0.01333351,
0.011119158,
-0.013387684,
0.028251601,
0.008457874,
0.0070154984,
0.024676135,
0.00530564,
0.010272694,
-0.015629122,
-0.0067006135,
0.041632514,
0.0057864315,
-0.013157445,
0.022929031,
0.0086745685,
-0.0028576644,
-0.024567787,
0.000634002,
-0.00036292168,
-0.04650815,
-0.0011249514,
0.03751531,
0.028982947,
-0.0047639026,
0.008525591,
-0.02008491,
-0.008254723,
-0.004465947,
-0.012629251,
0.020179715,
-0.04407033,
0.0049094944,
-0.0061724195,
-0.0001978611,
-0.003582238,
-0.00453705,
0.02264462,
0.018974349,
0.018920176,
-0.0000047183785,
0.021493427,
0.019935934,
0.022874858,
0.0038903512,
0.0056239106,
-0.0117692435,
-0.029226728,
0.0108076595,
0.005881236,
-0.040928256,
-0.0121281445,
-0.015155101,
0.0032825896,
0.0023311635,
-0.016279206,
0.026612846,
0.002536008,
0.0031403834,
0.0039106663,
-0.007712985,
0.02000365,
-0.00053708174,
-0.020775625,
0.01404454,
-0.0006941009,
0.015480144,
-0.012141688,
0.00032038684,
-0.005678084,
-0.05520303,
-0.016902205,
-0.01104467,
0.02233312,
-0.026518041,
-0.0083156675,
-0.00042302065,
-0.0049061086,
-0.027425451,
0.005197292,
0.022576902,
-0.01033364,
0.011390027,
-0.00009729052,
0.009019926,
0.022698794,
-0.011687983,
0.014762342,
-0.016306294,
-0.015249905,
-0.028332861,
0.020992322,
-0.02134445,
0.043609854,
-0.007597866,
0.019163957,
-0.020924604,
0.021764297,
-0.058128413,
-0.009101187,
-0.004804533,
0.015656209,
0.00931111,
0.023741638,
0.021588232,
0.0072728232,
-0.013326738,
0.014897776,
-0.00061622617,
0.013252249,
0.036350574,
-0.017579377,
0.033289757,
0.016197946,
-0.05392995,
-0.008566221,
0.03553797,
0.011390027,
0.012825631,
0.03198959,
0.013407999,
0.012331296,
-0.020762082,
-0.0025258502,
-0.008112516,
0.004296654,
0.0025664805,
-0.03924887,
-0.011809873,
0.021493427,
-0.0048316196,
0.016035425,
-0.009940879,
0.0013162524,
0.008931894,
-0.012019796,
0.00010522613,
-0.0036601129,
0.005464775,
-0.0074218013,
0.006761559,
0.022021621,
-0.011037898,
0.0014533796,
0.010530019,
-0.00688345,
-0.015561405,
0.01155932,
0.021046495,
-0.019895302,
-0.002006121,
0.0003421833,
0.00042132774,
0.016793856,
-0.008572993,
-0.013116815,
-0.008105745,
0.019353565,
0.00016315604,
0.0041679917,
0.020572474,
0.010130487,
-0.010658681,
-0.011484831,
0.015561405,
-0.025190786,
-0.008965753,
-0.0009903635,
-0.008999611,
-0.013150673,
-0.023741638,
0.011572863,
-0.0085797645,
0.0015574947,
0.009480403,
-0.02714104,
-0.011315539,
0.006659983,
0.19545883,
-0.0114103425,
-0.010875377,
-0.012385469,
-0.01940774,
-0.013780443,
0.02623363,
0.005921866,
-0.008593308,
0.02998516,
0.023443682,
-0.011301994,
-0.012595393,
-0.009019926,
0.016780313,
-0.023403052,
0.00010152284,
-0.009344969,
-0.008058342,
-0.030743593,
-0.006690456,
0.018513873,
0.021114212,
-0.003870036,
0.00868134,
0.0009692019,
0.0028068766,
0.028982947,
0.034129452,
0.02066728,
-0.019990107,
0.019042067,
0.014653995,
-0.005102488,
0.0068936073,
-0.0093720555,
-0.016753227,
-0.019299392,
0.0053801285,
0.0056239106,
-0.018215917,
-0.008512047,
-0.011579636,
0.009433001,
0.0021364766,
0.025082437,
-0.008911579,
-0.024337549,
-0.00788905,
-0.0031132966,
-0.027628602,
0.020017194,
0.007807789,
0.0033249129,
0.016861575,
-0.005464775,
0.016902205,
0.010922778,
0.0011105615,
-0.0012002868,
0.0071780193,
-0.009785131,
-0.01266311,
0.024012506,
-0.012209405,
0.025502285,
-0.020626647,
-0.014464387,
0.009893478,
0.009527805,
-0.0049772114,
-0.0064805327,
-0.0074218013,
-0.005684856,
0.009927336,
-0.017335594,
0.016360467,
0.027899472,
0.00583722,
0.012520904,
0.011491603,
-0.004489648,
-0.019380653,
0.023877073,
-0.014410213,
-0.028495383,
0.027506713,
0.004462561,
-0.02359266,
-0.0002911838,
-0.005867692,
-0.013340281,
-0.0085797645,
-0.008600079,
0.015222819,
-0.002910145,
0.013672096,
0.0063417125,
-0.00021553104,
-0.007523377,
-0.03735279,
0.09827115,
-0.0017250947,
0.0076588113,
-0.021141298,
0.0111462455,
-0.013821073,
0.006571951,
-0.007550464,
0.008173462,
0.00970387,
-0.026179455,
0.00060649187,
-0.0035653086,
0.001459305,
0.035212927,
-0.0067243143,
-0.010191433,
0.026897257,
-0.0087693725,
0.00027615906,
-0.03708192,
-0.0056272964,
0.023714552,
-0.011857276,
0.00065220095,
-0.0024039594,
0.0040528723,
-0.014843603,
-0.038327914,
-0.00439823,
-0.021019408,
0.0023717936,
0.0040054703,
0.0086745685,
-0.0033536926,
0.0026951432,
-0.015358252,
-0.014152887,
0.016238576,
0.008552678,
-0.008904807,
0.0022668322,
0.0043169693,
0.0157781,
-0.017024094,
0.03578175,
0.021357995,
-0.026111739,
-0.03188124,
-0.011423886,
-0.011471287,
-0.0005946414,
-0.013895562,
0.02059956,
-0.0012637716,
-0.041524164,
-0.022292491,
0.0013128666,
0.0191775,
-0.026694106,
0.008457874,
0.0063112397,
0.007841648,
-0.0023734865,
-0.024202114,
-0.17173073,
0.018811828,
0.02773695,
-0.0084849605,
0.04336607,
-0.0043779146,
-0.0068428195,
0.0049568964,
-0.0017555675,
0.0007178019,
0.04301394,
0.005227765,
-0.0315562,
-0.023308247,
0.008532363,
0.004990755,
-0.007523377,
0.024256289,
0.024351092,
0.014599821,
0.011647352,
-0.01613023,
-0.011227506,
-0.012893348,
-0.009189219,
-0.009331426,
0.0061690337,
-0.01791796,
-0.018486787,
-0.015453057,
-0.01645527,
-0.0076114093,
-0.0007029888,
0.020206802,
0.004015628,
0.0054817046,
0.010306552,
0.018689938,
0.010103401,
0.026843084,
0.0099950535,
-0.0011173332,
-0.004713115,
0.0011503453,
-0.023917703,
0.032585498,
-0.010435215,
-0.032639675,
0.021046495,
0.0007779009,
0.022698794,
-0.01017789,
0.0024090381,
0.021019408,
0.009453316,
0.023172814,
0.017972136,
0.0065956516,
-0.0049061086,
0.018879546,
0.022455012,
-0.019610891,
0.0065821083,
0.0004917959,
-0.00425941,
-0.012283893,
0.007211878,
0.0014990887,
-0.017809615,
0.0017623391,
-0.031420764,
0.0099950535,
0.0031860925,
-0.0036905855,
0.040223997,
0.025827326,
-0.016888661,
-0.0019502543,
-0.004709729,
-0.006900379,
-0.005349656,
0.007868734,
-0.022075796,
-0.013536661,
-0.0051939064,
0.013279336,
0.02237375,
-0.0050483146,
0.002175414,
-0.008823547,
0.010008597,
-0.030933201,
0.026897257,
-0.00059887365,
0.007855191,
0.030310202,
0.001957026,
-0.0014127493,
0.0090334695,
-0.01013726,
0.020802712,
-0.006636282,
-0.0058406056,
0.0010030605,
0.010096629,
-0.024391722,
-0.00028631664,
-0.013231934,
0.015439513,
-0.012886576,
0.002866129,
0.016848031,
0.01451856,
0.038978,
-0.013022011,
0.014220605,
-0.0076114093,
-0.019868216,
-0.016441727,
-0.035294186,
0.053686168,
0.017863788,
-0.017186616,
0.021683035,
0.014938407,
-0.002194036,
-0.12947522,
-0.022631077,
0.009304338,
0.009399142,
-0.009615838,
0.015751012,
-0.004919652,
0.0067243143,
-0.02208934,
0.03483371,
-0.012696968,
-0.026450325,
-0.013245477,
-0.0014770806,
0.04856675,
-0.012365154,
0.009019926,
-0.025556458,
-0.016021881,
0.033831496,
0.015155101,
-0.0022583674,
0.00016844645,
-0.009155361,
-0.0061047026,
0.020572474,
-0.028034907,
0.047158234,
0.023849985,
0.03664853,
0.010225292,
-0.014884233,
0.02153406,
-0.0056442255,
-0.03583592,
-0.016346924,
-0.028793339,
-0.0272223,
0.03594427,
-0.008471417,
0.005058472,
0.02126319,
0.01164058,
-0.016604248,
-0.0059828116,
-0.004794375,
-0.029660119,
-0.018094026,
0.023199901,
-0.016197946,
-0.028197426,
-0.026992062,
-0.028820425,
0.01621149,
0.015128015,
-0.027019149,
-0.0045539793,
0.01707827,
-0.028495383,
-0.011938537,
0.013387684,
-0.020856887,
-0.0012959372,
0.0012045191,
0.00005782411,
-0.0088438615,
-0.023565574,
-0.029064206,
0.0069071506,
-0.015723925,
-0.0075572357,
-0.015886446,
-0.021913275,
-0.016983464,
-0.009155361,
0.0064331307,
0.0017606462,
-0.015155101,
-0.0013721191,
-0.010164347,
-0.019502543,
-0.009223077,
0.019231675,
-0.024730308,
0.025068894,
0.00010660163,
0.018784741,
0.0035890096,
0.0041442905,
-0.0061995066,
-0.01676677,
0.01724079,
-0.007977082,
-0.0006835201,
0.010062771,
0.0038531066,
-0.0016412948,
-0.0034738905,
0.015534317,
0.013462172,
-0.010225292,
-0.009554892,
-0.06961325,
0.015615578,
-0.002793333,
-0.01940774,
0.009927336,
-0.02982264,
-0.0026578987,
-0.02963303,
0.01329288,
0.0073676277,
-0.033777323,
-0.009670011,
-0.018337809,
0.012263578,
-0.015791643,
-0.0112410495,
0.027642146,
-0.0015972786,
0.034887884,
0.029605944,
-0.00030642017,
0.00073896354,
0.0013661938,
0.03234172,
0.018337809,
-0.008159919,
-0.019461913,
0.031258244,
-0.0004668252,
-0.012162003,
0.013509574,
-0.030147681,
-0.0034535753,
0.008789688,
-0.012067199,
-0.009256937,
0.020978777,
0.036133878,
0.01724079,
0.030201856,
-0.016753227,
-0.035727575,
0.034942057,
0.008688112,
-0.011356168,
0.009141817,
-0.034508668,
0.026369063,
-0.015561405,
-0.02844121,
0.03664853,
-0.001743717,
-0.0008329211,
-0.032206282,
-0.030066421,
0.021412168,
0.014965493,
-0.0037684601,
-0.018906632,
0.0036262542,
0.015290536,
0.005711943,
0.0074353446,
-0.009907021,
-0.005254852,
-0.0036160967,
-0.03854461,
0.012575078,
0.0004943353,
-0.0093720555,
-0.026545128,
0.014017453,
-0.012683425,
0.009378827,
-0.00035763127,
0.005302254,
0.00883709,
0.016997008,
0.0037684601,
0.0031810137,
0.004665713,
-0.008308896,
-0.010963409,
0.0047706743,
-0.011105615,
0.01061128,
-0.0006221514,
0.026247174,
0.0023074623,
-0.0023802584,
-0.0031674705,
0.018771198,
-0.000045656183,
0.02544811,
-0.0002962626,
0.029091293,
-0.004184921,
0.0033858581,
0.022306034,
0.035646316,
0.00087439787,
0.00702227,
0.008918351,
-0.018730568,
-0.013780443,
0.024784483,
-0.04943353,
-0.015507231,
-0.012636023,
-0.009256937,
0.005823676,
0.029605944,
-0.00031488482,
0.012852718,
-0.010164347,
0.025502285,
0.015209275,
-0.023132183,
-0.009338197,
0.03456284,
0.014775885,
0.015033211,
-0.0054850904,
0.008302124,
0.011017582,
0.019990107,
0.0036871997,
-0.024283376,
0.030472724,
-0.010706084,
0.010062771,
-0.016021881,
-0.013008467,
-0.0016506059,
-0.01451856,
-0.037813265,
0.008464646,
0.008471417,
-0.0075775506,
0.08976588,
0.022780053,
-0.012825631,
0.016346924,
-0.01703764,
0.011809873,
-0.010394584,
0.013645008,
-0.00079779286,
-0.02087043,
0.017660636,
-0.0036804278,
0.017850244,
-0.032883454,
-0.021141298,
0.0030642017,
0.014667538,
0.022956118,
-0.008918351,
-0.032206282,
0.013008467,
-0.0002033631,
0.008552678,
-0.0029541613,
-0.018446155,
-0.015249905,
0.019895302,
-0.02998516,
0.0016006645,
-0.039980214,
-0.010110172,
0.02982264,
-0.051817175,
-0.008654254,
0.0073134536,
-0.016820943,
0.004557365,
-0.024730308,
-0.015317623,
-0.005732258,
-0.018689938,
0.026937889,
-0.013116815,
-0.026572214,
0.0065821083,
-0.03949265,
-0.055582248,
-0.013462172,
-0.0059794257
] |
The mammalian cerebral cortex is responsible for the highest levels of associative, cognitive and motor functions. In the central nervous system (CNS) the cortex stands as a prime example of extreme neuronal diversity, broadly classified into excitatory projection neurons (PNs) and inhibitory interneurons (INs). We review here recent progress made in understanding the strategies and mechanisms that shape PN diversity during embryogenesis, and discuss how PN classes may be maintained, postnatally, for the life of the organism. In addition, we consider the intriguing possibility that PNs may be amenable to directed reprogramming of their class-specific features to allow enhanced | [
-0.008227847,
0.01632288,
-0.0034133277,
-0.035302043,
-0.025832383,
0.0026712278,
0.007789559,
0.011495078,
-0.026323795,
-0.016030686,
-0.0036590341,
0.00041193186,
0.002276105,
-0.0038549353,
-0.015924435,
0.011820473,
0.028183196,
0.0013231626,
-0.011256012,
-0.008101673,
-0.024676898,
0.006109458,
-0.013241586,
-0.0113091385,
0.02423861,
0.005149875,
-0.006919625,
-0.020665906,
-0.0001587546,
-0.01976277,
0.009781773,
0.0011521641,
0.005511794,
-0.02182139,
0.0009894666,
-0.006786811,
0.023508132,
-0.015286926,
-0.0124978265,
0.017637739,
0.018886194,
0.0018162356,
0.00016705549,
-0.000621737,
0.010983743,
-0.00033909152,
-0.023508132,
0.0013480652,
-0.0007769637,
0.014543166,
0.029086333,
0.027891004,
0.00006998691,
0.011163043,
-0.016694758,
-0.016043968,
-0.0011405429,
0.008081751,
0.020280745,
-0.022618277,
0.006434853,
0.007975499,
-0.015791621,
0.02794413,
-0.0002618932,
-0.0061227395,
-0.002988322,
0.01077124,
0.010147013,
-0.013321275,
0.045661557,
0.012092742,
-0.0141712865,
-0.017066639,
0.02405267,
-0.0030397875,
-0.01605725,
-0.004967255,
-0.021927642,
0.0042932224,
0.016455693,
-0.040720865,
-0.012152509,
0.033947337,
0.013175179,
0.0066805594,
0.01549943,
0.008148158,
0.009383331,
0.011256012,
0.014131442,
0.010067324,
0.018886194,
-0.0060198084,
0.004681704,
0.020001834,
-0.0031443788,
-0.0020752235,
-0.0010318011,
-0.010498971,
-0.0067170835,
0.025978478,
-0.012411497,
-0.020227619,
-0.014715825,
0.013288071,
0.008154798,
-0.0016908922,
0.024544084,
-0.0019241472,
0.0075239306,
0.025978478,
-0.002486948,
-0.060882077,
0.01883307,
-0.0029285555,
0.021130756,
-0.0035494624,
0.0035859863,
0.0037520041,
0.01892604,
0.015579118,
0.0058637518,
-0.0063916883,
0.002654626,
0.014596292,
-0.007351272,
-0.007882529,
-0.010877492,
-0.006471377,
-0.0030530689,
-0.010286468,
0.0062887575,
0.02042684,
-0.0013314635,
0.015791621,
-0.003971148,
-0.00095377275,
-0.0120130535,
-0.021290133,
0.011627893,
0.009111062,
-0.009310283,
0.0054188236,
0.0021980768,
0.04874285,
0.027226932,
0.022419054,
0.03315045,
0.0074973674,
0.014131442,
-0.009569271,
0.012471263,
-0.009549349,
-0.01300252,
0.016827572,
0.004728189,
0.036444247,
-0.004771354,
-0.014848639,
0.010346235,
-0.018819787,
-0.014144723,
0.006703802,
0.04040211,
0.02394642,
0.011986491,
0.0097020855,
0.02507534,
0.0036590341,
0.0052328836,
0.010824366,
-0.030095723,
0.020626063,
-0.01717289,
-0.003194184,
0.024637055,
0.005744219,
-0.023096409,
-0.01569865,
0.024105797,
0.0046186177,
0.008951684,
-0.0029418368,
-0.0071985354,
-0.012723611,
0.039233346,
-0.034691095,
-0.009522785,
-0.018062746,
-0.015725214,
-0.0046186177,
-0.029378524,
-0.0243183,
-0.6485588,
-0.006511221,
0.02403939,
-0.02154248,
0.0035162587,
0.020041678,
0.0029302156,
-0.014715825,
-0.008380583,
0.030148847,
-0.005428785,
0.002369075,
0.0027143925,
-0.017345548,
-0.029564464,
-0.020320589,
0.0010508932,
0.00025732772,
0.00992787,
-0.015618962,
-0.00687314,
0.0040143123,
-0.023972983,
0.015911154,
-0.002274445,
0.01467598,
0.022166708,
0.0035627438,
-0.0064580957,
0.018554159,
-0.028209759,
0.013341197,
-0.010605223,
-0.00015968845,
0.03668331,
0.004781315,
-0.01903229,
0.03973804,
-0.015180675,
0.058810174,
-0.011860318,
-0.0020287386,
0.0057873833,
0.0037553245,
-0.019284638,
0.028369136,
-0.0109571805,
-0.023176096,
0.007444242,
-0.034133278,
0.009044655,
-0.0014584671,
-0.0072583016,
0.0059367996,
-0.0042400965,
0.0011173004,
-0.00044783324,
-0.007185254,
-0.004894207,
0.0038748574,
-0.0017315665,
-0.008626289,
-0.024185484,
-0.034691095,
-0.012590796,
0.021369822,
-0.03453172,
-0.016668195,
-0.0048211594,
-0.01569865,
0.007869247,
0.0276785,
-0.024464395,
0.0021416307,
-0.003323678,
0.0011031888,
0.0078294035,
-0.011056791,
0.0016352761,
0.016548663,
-0.009243876,
-0.012318527,
-0.038675524,
-0.005003779,
-0.0032539505,
-0.029776968,
0.0045256475,
-0.001894264,
0.0028073625,
-0.00017546015,
-0.0038283723,
-0.0075239306,
-0.014808795,
-0.032459818,
-0.014915046,
0.021754984,
0.0023342115,
0.0035959473,
-0.0019623314,
-0.0131353345,
-0.005412183,
-0.016880699,
-0.0018029542,
-0.006079575,
0.03006916,
0.0024852876,
-0.008114954,
0.035434857,
0.03870209,
-0.038277082,
-0.02143623,
-0.0043397075,
0.0069528287,
0.008433708,
0.014357227,
-0.020546373,
0.0045787734,
0.009277079,
-0.012484545,
-0.013500574,
0.008719259,
0.0011189606,
-0.008712619,
-0.0144369155,
0.019815894,
0.0038848184,
-0.008221205,
-0.02042684,
-0.005671171,
0.0054188236,
-0.016136939,
0.0017880126,
0.018461188,
-0.0068399366,
0.010047402,
0.012285323,
0.012657204,
-0.010824366,
-0.01866041,
-0.031583242,
-0.035912987,
-0.013281431,
0.0034133277,
0.004260019,
-0.028953519,
-0.013248227,
-0.037188005,
0.013706436,
-0.0146627,
-0.0068266555,
-0.010990384,
-0.0117275035,
0.010014199,
0.026894897,
0.013679873,
-0.00015481167,
-0.00426998,
0.004671743,
-0.0070059546,
-0.027811315,
-0.003556103,
0.01754477,
-0.013487292,
0.02749256,
-0.042819332,
-0.019178385,
-0.006932907,
0.021861235,
-0.015512711,
-0.039977107,
0.004817839,
0.0150080165,
0.004947333,
-0.010173576,
0.0065311436,
0.0015174034,
0.011687659,
-0.025606599,
0.0037619653,
-0.009595834,
-0.0043131444,
-0.013480652,
-0.00844699,
-0.027811315,
0.021582324,
0.0036324712,
0.03686925,
0.0034465312,
-0.00901145,
0.029537901,
0.007371194,
0.036258306,
-0.02340188,
0.003081292,
-0.010811085,
0.004379552,
0.013407604,
0.0005370678,
-0.014689262,
0.027811315,
0.016190063,
-0.021648731,
-0.0000059208724,
-0.003453172,
0.022525307,
-0.025473785,
-0.0005735918,
-0.019975271,
0.004505725,
0.0013472352,
-0.00039761284,
0.004382872,
-0.0061493022,
-0.027306622,
-0.010007558,
0.022299523,
-0.0024421231,
-0.0015655486,
-0.019072134,
-0.022618277,
0.0019523703,
0.013161898,
0.011335701,
0.027997255,
0.006527823,
0.024464395,
-0.0006972751,
0.016827572,
-0.0064746975,
-0.016482254,
-0.018354937,
0.04345684,
0.019815894,
0.017890086,
0.008254409,
0.010498971,
0.016668195,
0.0024388027,
0.040083356,
0.019656517,
0.009795055,
0.03535517,
-0.00909778,
-0.011481796,
0.017318986,
-0.020745594,
0.013108772,
0.0027608774,
-0.005970003,
0.008294254,
-0.019895583,
-0.009429816,
-0.03572705,
-0.0018494392,
0.005727617,
0.010817725,
0.005319213,
0.013892377,
0.0276785,
0.03006916,
0.008108313,
-0.03686925,
0.012524389,
-0.014091598,
-0.0022943672,
-0.024477677,
0.0111763235,
-0.022259677,
0.006504581,
-0.010744677,
-0.022830779,
-0.0020586217,
0.0066241133,
-0.03163637,
0.01207282,
0.011202887,
0.0011388827,
0.022830779,
0.008347379,
0.02507534,
-0.012517748,
-0.025420658,
0.0008230336,
0.030573852,
-0.016588507,
-0.011634533,
-0.02144951,
0.009522785,
-0.014370508,
-0.00956263,
0.0032473097,
0.019324481,
-0.021808108,
0.0069528287,
-0.013288071,
-0.018222123,
0.0060662935,
0.008141517,
-0.0062157097,
-0.023362037,
0.016482254,
0.007105565,
-0.0174518,
0.016123656,
0.018979164,
0.009662241,
-0.008938403,
-0.009722007,
0.003944585,
-0.012119305,
0.009516145,
-0.012989239,
0.0045854137,
-0.004791276,
-0.0031427185,
-0.00080518675,
-0.0052793687,
-0.0111099165,
0.026562862,
0.017040076,
-0.010910695,
-0.02479643,
0.000770323,
-0.025473785,
0.038409896,
0.00807511,
-0.03766614,
0.034691095,
-0.005674491,
-0.011123198,
-0.03833021,
-0.0038615759,
0.037453633,
-0.015632244,
-0.01808931,
-0.000454889,
0.017983057,
0.00057774223,
0.045847498,
0.028741015,
-0.0041238843,
0.00040549866,
-0.01799634,
-0.010366157,
0.0243183,
0.0010525534,
0.025951914,
0.019789333,
0.017717429,
0.009449738,
0.021555763,
0.034584846,
0.0068332963,
-0.022020612,
-0.006760248,
0.020227619,
-0.011900161,
0.018673692,
-0.0005698564,
-0.001940749,
0.0013895697,
-0.009888025,
0.0063186404,
0.00992787,
-0.0006744476,
0.018514315,
-0.0011430332,
-0.00733135,
0.013075569,
-0.02654958,
0.013693155,
0.0057873833,
-0.0025666365,
-0.011249372,
0.018700255,
0.0075239306,
-0.0015987522,
-0.005422144,
0.018301811,
-0.005867072,
-0.007437601,
0.011647815,
-0.0033087365,
-0.014968173,
-0.0027143925,
0.0034100073,
-0.018354937,
-0.01800962,
-0.010432564,
-0.015618962,
0.0042102137,
-0.0056379675,
-0.027651938,
-0.009768493,
0.0074708047,
-0.03657706,
-0.03641768,
-0.022033893,
0.039658353,
0.025765976,
0.024504239,
-0.0115946885,
0.004429357,
0.033362955,
0.01698695,
-0.01419785,
-0.011827114,
-0.02552691,
-0.00096539396,
0.0012318527,
0.017119763,
-0.008380583,
-0.0029999432,
-0.0005262767,
0.015247082,
-0.0451303,
0.0061758654,
0.022485463,
-0.0025500348,
0.0048875664,
0.029112896,
0.032194186,
0.001847779,
-0.023654228,
0.0038748574,
-0.015340053,
-0.022392493,
-0.022246396,
0.010505612,
-0.015751777,
-0.0058869943,
0.004900848,
-0.019457296,
-0.000798546,
0.031955123,
-0.020586217,
0.028209759,
0.025274562,
0.0051365932,
0.023694072,
0.005541677,
0.037161443,
-0.0034697738,
-0.016043968,
0.014118161,
-0.013208383,
0.044306852,
0.02329563,
-0.05291322,
0.012225557,
-0.006424892,
-0.009443097,
-0.021144038,
-0.015220519,
0.013015802,
0.0469897,
-0.009117702,
-0.026390202,
-0.00053997315,
0.010831007,
-0.014768951,
0.005578201,
-0.025248,
0.009257157,
-0.009024732,
-0.005800665,
0.0005868732,
-0.016110376,
0.0165221,
-0.03750676,
-0.0006101157,
0.035302043,
0.0029816811,
0.009755211,
-0.016548663,
0.0050070994,
-0.010200139,
-0.002925235,
-0.024902683,
-0.018819787,
-0.004309824,
-0.026523016,
0.028448824,
0.038489588,
0.036072366,
-0.0031775823,
-0.0020901652,
0.03370827,
-0.0004752262,
-0.0014576371,
0.0067071225,
0.014596292,
-0.016216626,
0.021409666,
0.0008840452,
0.0061758654,
0.025513628,
0.008672774,
-0.0088188695,
0.007158691,
0.0014651078,
-0.013055646,
-0.008719259,
-0.009456378,
-0.021037785,
0.026058167,
-0.011056791,
-0.0013605165,
-0.021569043,
0.016203346,
0.025659723,
0.012019695,
0.00081680797,
-0.0051266323,
0.0076102596,
-0.009695444,
0.011455234,
0.0037453633,
0.021024505,
-0.0020569616,
-0.0060496917,
-0.013294712,
0.00069395476,
-0.0006723724,
0.009509505,
0.035328604,
0.0053490964,
0.019364325,
-0.005740898,
0.014383789,
-0.03017541,
0.011760707,
-0.023654228,
-0.025978478,
-0.012869706,
-0.004678384,
-0.016827572,
-0.013759562,
0.010558737,
0.0052959705,
-0.008473553,
0.028475387,
-0.03307076,
-0.019444015,
0.022392493,
-0.014516603,
0.04364278,
-0.02580582,
0.006806733,
0.023972983,
0.010100528,
-0.005691093,
-0.014330664,
-0.0068930625,
0.00051839085,
0.047175642,
0.018036183,
0.010983743,
-0.025433939,
-0.002838906,
0.024504239,
-0.00194905,
-0.030547291,
0.020254182,
0.0019241472,
0.012683766,
-0.007530571,
0.007762996,
-0.0035395012,
0.016070532,
-0.027147245,
-0.011654455,
0.006932907,
-0.022100301,
-0.014888484,
0.020400278,
-0.0051299524,
0.0014783893,
-0.007205176,
0.007284865,
-0.0013480652,
0.015765058,
-0.0067635686,
0.0028555077,
0.004967255,
0.022047175,
-0.0048975274,
0.009609115,
0.013586904,
-0.003961187,
-0.0030995538,
-0.007231739,
0.008101673,
0.03519579,
0.001847779,
-0.02831601,
0.007231739,
0.011833754,
0.0064680567,
-0.033575457,
0.0048875664,
-0.014636137,
-0.020280745,
0.009323564,
0.030494165,
-0.0063086795,
-0.0022262998,
-0.0059832847,
-0.009130984,
0.0059534013,
-0.05208977,
0.001466768,
-0.0101204505,
-0.025752693,
-0.020679187,
0.014994735,
-0.0043297466,
0.020572936,
0.007583697,
-0.010605223,
-0.013261508,
0.024597209,
0.0041172435,
0.017199453,
0.0050569046,
-0.0025765975,
-0.053577293,
-0.00021416307,
-0.031530116,
-0.007855966,
0.018554159,
-0.026682394,
-0.030494165,
0.009403253,
0.011687659,
0.021024505,
0.006743646,
-0.019815894,
0.0006985202,
0.014184568,
0.009961073,
0.002367415,
-0.02662927,
0.005282689,
-0.02329563,
-0.024198767,
0.020944817,
-0.02913946,
-0.019457296,
-0.02405267,
-0.012922832,
0.029564464,
-0.026589423,
0.013945502,
-0.020904971,
0.026868334,
-0.0049440125,
0.013387682,
0.0067204037,
-0.0071188468,
-0.036337994,
0.019085417,
0.008221205,
-0.01122945,
0.001411152,
0.0037188006,
0.019616673,
0.0053723385,
-0.025035497,
-0.0020386996,
0.019072134,
-0.040136483,
-0.057216402,
0.005551638,
-0.015525992,
0.030759793,
0.025765976,
-0.0031443788,
0.0028189837,
-0.007324709,
-0.05094757,
-0.018434625,
-0.0012044597,
0.025580036,
0.005737578,
0.011030228,
0.003911381,
-0.0038682166,
0.0215292,
-0.0020303987,
-0.0011214508,
-0.014928328,
0.010073965,
0.00078111415,
0.012046258,
0.01067827,
-0.04454592,
-0.016920542,
0.035222355,
-0.011368904,
-0.0039014202,
0.04157088,
-0.017611178,
0.022033893,
0.0013796086,
0.009230594,
-0.0006815034,
0.018647129,
0.014304101,
-0.01642913,
-0.0090180915,
-0.001290789,
-0.013341197,
-0.0072184578,
-0.004611977,
-0.012816581,
-0.0068200147,
0.007138769,
-0.015818184,
-0.0071321283,
0.030653542,
0.0084005045,
0.011913443,
0.012139227,
0.007743074,
0.013301353,
0.013772843,
0.0051863985,
-0.031769183,
-0.02599176,
-0.016043968,
-0.0045156865,
-0.0016219947,
-0.012650562,
-0.01160797,
0.0011297517,
0.036444247,
-0.047494397,
-0.0038184114,
-0.005511794,
0.009323564,
-0.021927642,
0.012132587,
-0.00088819565,
-0.0119466465,
-0.0007740584,
-0.0071188468,
-0.0000055966184,
-0.019430732,
-0.0055449973,
0.008546601,
-0.022923749,
0.013241586,
0.013626748,
-0.009383331,
-0.0051133507,
-0.024012826,
-0.004213534,
-0.006806733,
0.0041836505,
0.1573584,
-0.008002062,
0.017863525,
0.0024305019,
0.0014011909,
0.021223726,
0.010751318,
0.0003065105,
0.01800962,
-0.017956493,
-0.0027608774,
0.016415847,
-0.020161211,
0.004930731,
0.03556767,
-0.025221437,
-0.012331808,
-0.01819556,
-0.0030414476,
-0.0011106597,
0.007855966,
-0.031211361,
0.022684684,
-0.007039158,
0.033283263,
-0.0013779484,
-0.011515,
-0.007696589,
-0.0003610889,
0.016548663,
-0.019643236,
0.025673006,
-0.00853996,
0.007025877,
-0.01828853,
-0.0058869943,
0.012491185,
-0.008420427,
0.0057043745,
-0.018368218,
0.024358144,
0.0074309604,
0.034956727,
0.01540646,
-0.0014086617,
0.0134009635,
0.007988781,
-0.0015887911,
-0.016681477,
0.015525992,
-0.043111525,
0.025872227,
0.020360433,
0.030334787,
-0.0010533835,
0.009575912,
0.0023275707,
0.0052395244,
0.019324481,
0.012524389,
-0.021688577,
0.013128694,
-0.024411269,
0.037984893,
0.011196246,
0.021901079,
-0.013573622,
0.015313489,
0.0010326313,
0.00096705416,
-0.0058869943,
0.0036258306,
-0.024597209,
-0.003758645,
-0.007855966,
-0.019231511,
0.036444247,
0.007809481,
0.033575457,
0.02757225,
-0.005133273,
-0.008712619,
-0.007882529,
-0.010286468,
-0.019576829,
-0.052966345,
0.023614384,
-0.005133273,
-0.0043529887,
-0.012624,
0.0033934056,
-0.018408062,
-0.008460271,
-0.03474422,
0.007397757,
-0.005930159,
0.008553241,
0.024079233,
-0.02014793,
-0.00018988295,
-0.044599045,
0.0700197,
0.023176096,
0.009223954,
-0.01039936,
0.004047516,
0.02079872,
0.014702544,
-0.0016195044,
-0.0088188695,
0.0118802395,
-0.018394781,
-0.0029036528,
0.0015605681,
-0.01467598,
0.0019457296,
0.008891918,
-0.02571285,
0.021834671,
-0.013527137,
0.0021432908,
-0.035620797,
-0.012816581,
0.012683766,
0.019483859,
-0.00013758733,
-0.026775364,
0.013865814,
0.014928328,
-0.040136483,
0.0019955349,
-0.028289447,
0.011023588,
-0.016960386,
-0.004499085,
-0.011886881,
0.025951914,
-0.002217999,
-0.0022047174,
0.016880699,
-0.010465767,
-0.023375317,
0.0000406225,
0.02172842,
0.00853996,
-0.01383925,
0.011873599,
0.03601924,
-0.022976875,
-0.0022412415,
-0.019178385,
-0.025885507,
0.01150836,
0.0060297693,
0.018726816,
-0.0032738727,
-0.010147013,
-0.038941156,
-0.012477904,
0.0025550153,
-0.034425467,
-0.011036869,
0.0052893297,
-0.008659493,
-0.009761851,
0.0037055193,
-0.16681477,
0.00096954446,
0.014596292,
-0.0243183,
0.015167394,
0.016734602,
0.017318986,
-0.023415161,
0.009164187,
-0.0016817611,
0.015446303,
-0.00019009048,
-0.0198823,
-0.014915046,
0.00031398132,
0.00733799,
0.013281431,
0.013268149,
0.0048809256,
0.007955577,
0.020254182,
-0.04077399,
0.012876347,
-0.006853218,
0.0049606143,
0.009589192,
-0.014729107,
-0.0054553477,
0.018076027,
-0.048583474,
0.01132906,
-0.013600185,
0.033575457,
-0.013666593,
0.021675294,
0.0035395012,
-0.03017541,
-0.027811315,
-0.0050668656,
0.009024732,
0.011016946,
0.024278454,
0.0019390889,
0.0021781547,
-0.009662241,
-0.019351045,
-0.018049464,
-0.01698695,
0.0141712865,
-0.013918939,
0.018594002,
0.005966683,
0.00473151,
0.008978247,
0.027147245,
0.016455693,
0.0056379675,
0.007929014,
0.021768264,
-0.006743646,
-0.0075903377,
-0.020028397,
0.011827114,
0.024251893,
0.008300894,
-0.013447449,
0.013440807,
0.011554845,
-0.034452032,
0.0046086563,
-0.005840509,
-0.008546601,
0.02050653,
-0.03240669,
0.013434167,
0.00919075,
0.003192524,
-0.011182965,
0.0032622514,
0.014529885,
-0.000025732772,
0.008148158,
-0.03386765,
-0.009761851,
-0.02813007,
-0.032566067,
0.009429816,
0.014822077,
0.012843143,
0.0033934056,
-0.009197391,
-0.034478594,
0.010950539,
-0.0023624345,
0.004512366,
0.024384707,
-0.012484545,
-0.015087705,
0.0066672782,
-0.008214565,
-0.00041919516,
0.0019805934,
-0.028475387,
-0.007650104,
0.035594232,
-0.008945043,
-0.007530571,
0.02078544,
0.026762083,
0.0016634992,
0.01866041,
0.0020768838,
0.015300208,
0.03500985,
-0.004379552,
0.008865355,
0.0012227217,
-0.0025682966,
0.016694758,
0.011747425,
0.06948844,
0.004651821,
-0.0067801704,
-0.0002691565,
0.010200139,
-0.008480193,
-0.14630824,
-0.042155262,
-0.002525132,
0.030201973,
-0.022817498,
0.013985346,
-0.013221664,
0.04661782,
-0.027133962,
0.0479194,
-0.0065245028,
-0.010943899,
0.005740898,
-0.0020669226,
0.005734258,
-0.003164301,
-0.0062489132,
0.007324709,
-0.007955577,
0.015087705,
0.005511794,
-0.0005188059,
0.014861921,
-0.0065411045,
-0.015114268,
0.007696589,
-0.0075040082,
0.0038184114,
0.00510671,
-0.0063086795,
0.005050264,
-0.023999546,
0.025752693,
-0.008221205,
-0.018368218,
-0.004874285,
0.003954546,
-0.028873831,
0.03992398,
0.0122986045,
-0.0038383335,
0.008958325,
0.016415847,
0.0057575,
-0.008500116,
-0.0045422493,
-0.02061278,
-0.005395581,
0.008068469,
0.0029036528,
-0.03471766,
-0.02775819,
-0.011906803,
-0.004030914,
0.016548663,
0.010923977,
-0.009091139,
0.017318986,
-0.01653538,
-0.0014526565,
0.012975957,
-0.006617473,
-0.022259677,
0.01625647,
0.041199,
-0.008984888,
-0.025261281,
-0.044970926,
0.012624,
-0.031237924,
-0.004847722,
-0.0007093114,
-0.008347379,
-0.0134673705,
-0.03705519,
-0.0009255497,
-0.018354937,
0.0026396844,
-0.006162584,
0.008081751,
-0.01540646,
-0.026576143,
0.0062489132,
-0.013998628,
0.0076700263,
0.01819556,
0.010253265,
-0.015937718,
-0.003851615,
-0.004904168,
0.0013140315,
0.015419741,
0.011315779,
-0.0077297925,
0.0044725216,
-0.010558737,
-0.0037951688,
-0.0106915515,
0.014689262,
0.034611408,
-0.01959011,
-0.004724869,
-0.03936616,
0.021409666,
-0.0007367043,
-0.007743074,
0.013759562,
0.0008865355,
0.00946966,
-0.007689948,
-0.006043051,
0.020772157,
-0.02831601,
0.020015117,
-0.0010127091,
0.0094364565,
-0.034133278,
-0.015658807,
0.025420658,
-0.026204262,
-0.005189719,
0.0051266323,
0.011833754,
0.0075704153,
0.038197394,
-0.011866958,
-0.037081756,
-0.009449738,
-0.027891004,
-0.0011430332,
-0.009124343,
0.018461188,
0.00024383876,
-0.030016033,
0.0019075455,
0.028900392,
-0.00055449974,
-0.019736206,
0.0024803071,
0.020227619,
0.016203346,
0.05477262,
-0.034770787,
-0.06805405,
-0.007510649,
-0.0141712865,
-0.001494991,
-0.0025682966,
-0.034505155,
0.0061393413,
0.003675636,
-0.008679415,
0.012039617,
-0.014715825,
0.008626289,
-0.038648963,
-0.0066639576,
-0.0019025649,
0.011953288,
-0.008148158,
-0.008280972,
-0.026283951,
0.0026230826,
0.0013049005,
0.030201973,
-0.0064215716,
0.012670484,
-0.0007466654,
-0.03285826,
0.009761851,
-0.016203346,
-0.02599176,
-0.0063086795,
0.0029567785,
0.016402567,
-0.0002079374,
0.011747425,
-0.009954432,
0.018899476,
-0.007975499,
-0.027147245,
0.020015117,
0.016110376,
0.027811315,
-0.011455234,
0.020201055,
0.03538173,
0.009722007,
-0.01996199,
0.028528513,
-0.010565378,
0.023428444,
0.013407604,
0.015552555,
-0.0011563145,
0.004907489,
0.010950539,
0.012019695,
-0.019988554,
-0.026682394,
0.006092856,
0.006647356,
-0.0036158694,
0.010133731,
0.011348982,
-0.022073738,
0.0029468173,
0.00566453,
-0.03200825,
-0.032353565,
0.00008503228,
0.020453403,
0.0074840863,
0.012736892,
0.0036258306,
-0.0069528287,
-0.004675064,
0.03147699,
0.0023889972,
-0.002282746,
-0.015871309,
0.013221664,
0.02413236,
0.014277538,
0.008055188,
0.013447449,
0.008387224,
0.021462793,
0.027811315,
-0.034452032,
0.030520728,
0.0146627,
0.022047175,
-0.012610719,
-0.032752007,
0.00013748356,
-0.016190063,
-0.009263798,
0.0013887396,
0.01828853,
-0.004970575,
0.078254186,
-0.0084005045,
-0.010970462,
-0.019550266,
-0.012371653,
0.0019905544,
-0.01077124,
0.00770323,
-0.0034299295,
-0.006813374,
0.026576143,
-0.023322193,
0.030467601,
-0.024743306,
-0.0023225902,
0.019895583,
-0.015844747,
0.009549349,
0.008579805,
-0.023893293,
0.022671402,
-0.014928328,
0.029670715,
0.016548663,
-0.025513628,
0.005933479,
0.019244794,
0.0028820704,
0.008480193,
-0.038941156,
0.0064879786,
-0.012431419,
-0.057428908,
-0.0011363924,
-0.014795514,
0.004130525,
0.001216081,
-0.014490041,
-0.011182965,
0.021608887,
-0.0067071225,
0.0090180915,
-0.0015605681,
-0.027891004,
0.0072583016,
-0.0037453633,
-0.005093429,
-0.017292423,
-0.029219147
] |
Cell surface receptors have been extensively studied because they initiate and regulate signal transduction cascades leading to a variety of functional cellular outcomes. An important class of immune receptors (e.g., T-cell antigen receptors) whose ligands are anchored to the surfaces of other cells remain poorly understood. The mechanism by which ligand binding initiates receptor phosphorylation, a process termed "receptor triggering", remains controversial. Recently, direct measurements of the (two-dimensional) receptor-ligand complex lifetimes at cell-cell interface were found to be smaller than (three-dimensional) lifetimes in solution but the underlying mechanism is unknown. At the cell-cell interface, | [
-0.033133443,
0.009520272,
-0.00074798614,
-0.0115335435,
-0.0006809593,
0.016895687,
-0.007151718,
0.005148316,
-0.033133443,
-0.016540404,
0.020830119,
0.0020872883,
-0.027527863,
0.026843615,
-0.0022928922,
-0.000795275,
0.027633132,
0.005069364,
-0.028159479,
-0.0015535413,
-0.031738628,
0.015671933,
-0.0138823595,
-0.01426396,
-0.006483917,
0.026054097,
0.02043536,
-0.061319236,
-0.015079795,
-0.025317213,
-0.012974414,
0.0010370649,
-0.0362652,
0.011632233,
0.0074806837,
-0.011790137,
0.022106506,
0.007447787,
0.009572906,
0.011823033,
0.014461339,
0.022777596,
-0.000020059208,
-0.006227324,
-0.0009712717,
-0.0069346004,
0.020895911,
-0.0048357984,
-0.027922623,
0.03623888,
0.016408818,
0.0073754145,
0.0030610275,
-0.023830287,
-0.017329922,
-0.035238825,
-0.0077043804,
0.024277681,
0.013369173,
-0.03218602,
-0.03594939,
0.00004538701,
-0.014106057,
0.013244166,
0.020014284,
0.024146095,
0.013540235,
0.026830455,
-0.014856098,
-0.006174689,
0.009526852,
0.02630411,
0.008803126,
-0.00202314,
0.0074938424,
-0.019816903,
-0.015435078,
0.011901985,
-0.014277118,
0.015224541,
0.006776697,
-0.012599393,
-0.016408818,
0.035975706,
-0.008158353,
0.0073096217,
0.033186078,
-0.0038785075,
0.014342912,
-0.011138784,
-0.0028471996,
0.025488276,
0.014763988,
0.030501716,
-0.0065398416,
-0.008803126,
-0.0021711746,
0.026462015,
0.0014811688,
-0.021988079,
0.0014293566,
0.018632626,
-0.010342686,
-0.0185142,
-0.04202868,
0.009816341,
0.0029656272,
-0.024935612,
0.01417185,
0.0084544225,
-0.024777709,
0.033449247,
-0.004684474,
-0.02572513,
0.028212113,
0.015106113,
-0.01484294,
-0.0011061478,
0.0013002376,
-0.008599168,
0.02206703,
0.025856717,
-0.0017122673,
-0.010290053,
0.033422932,
0.02292234,
-0.010665073,
0.0029853652,
-0.009507113,
0.01455345,
-0.0017106225,
0.023146039,
-0.015395602,
0.008118877,
-0.0032452482,
-0.011099309,
-0.0017994433,
0.016145645,
0.0031876792,
-0.025290895,
0.014645561,
0.029475342,
-0.0057569025,
-0.0032156412,
0.020159028,
0.036581006,
0.033422932,
0.005437806,
0.0042732665,
0.007138559,
-0.00046260824,
0.012895462,
0.027738402,
0.0020395883,
-0.016369341,
0.021514367,
-0.012138841,
0.04394984,
0.0027534442,
-0.022685487,
0.0149218915,
-0.0060759997,
-0.0073425183,
0.0005876153,
0.02505404,
0.015842997,
0.01426396,
0.025014564,
-0.013895518,
0.0077899117,
-0.017816791,
0.025396165,
0.021540685,
0.0077833324,
-0.024922455,
0.00039578706,
0.016829893,
0.009112354,
-0.018922117,
-0.009526852,
-0.0034047968,
0.000513598,
0.019158972,
0.0013561618,
-0.016119327,
-0.002514944,
0.020974863,
-0.025501434,
0.016145645,
-0.0306333,
-0.0086452225,
0.024369791,
-0.0144218635,
-0.019224765,
-0.64382565,
-0.016277231,
0.032159705,
-0.011026936,
-0.004378536,
0.030396447,
0.006661559,
0.00424366,
-0.0061319238,
0.022790756,
0.0074346284,
-0.0057042683,
0.0074609458,
-0.029264804,
-0.027580498,
-0.024830343,
-0.023396052,
-0.015145589,
0.034265086,
0.005171343,
-0.015435078,
-0.010329528,
-0.0025100096,
0.020369567,
-0.00090630096,
0.0096387,
0.0072438284,
-0.017474666,
-0.0041416804,
0.035238825,
-0.028870044,
-0.0073622563,
0.0009523562,
0.008882078,
0.044581454,
0.011895406,
-0.0035166452,
0.039160095,
0.015527189,
0.033554517,
-0.008822865,
-0.00876365,
0.009086037,
-0.00094495446,
-0.026462015,
0.0047568465,
0.004779874,
0.017553618,
-0.011059833,
0.0007582663,
0.012691503,
0.0034804589,
-0.023790812,
0.025593545,
0.02022482,
-0.0023932266,
0.019514255,
0.013658662,
0.0052568745,
0.008263622,
-0.0038620592,
0.00015399714,
-0.0010469338,
-0.03152809,
-0.0054279366,
0.016461452,
-0.028659506,
0.022724962,
-0.016935162,
0.02264601,
0.019158972,
0.026317269,
-0.012355958,
-0.0007948638,
-0.012355958,
0.02119856,
0.015329809,
0.01195462,
-0.0033390035,
0.035501998,
0.01156644,
0.0034047968,
-0.045476243,
0.020356407,
0.020132711,
-0.007546477,
-0.0040528593,
0.010638756,
0.021040658,
-0.0075333184,
0.0036811281,
-0.0163825,
-0.030054322,
-0.040133834,
-0.03623888,
0.035870437,
-0.02138278,
-0.005250295,
0.018908959,
-0.020369567,
-0.0117638195,
-0.0032320896,
-0.020093234,
-0.001190034,
0.033396613,
-0.015211382,
-0.035580948,
0.0032880139,
0.06926705,
-0.026935725,
0.008085981,
-0.00848074,
-0.004441039,
0.008283361,
0.0075991116,
-0.013250745,
0.024369791,
0.023264466,
0.00031724645,
-0.010750605,
0.012296744,
0.025856717,
0.0009145251,
-0.022211775,
0.004615391,
0.027580498,
-0.020974863,
-0.019408986,
-0.003990356,
-0.008513637,
0.000007703712,
0.0043226113,
0.020290615,
-0.007526739,
0.025396165,
0.02043536,
0.022856548,
0.004770005,
0.00012079215,
-0.02150121,
-0.01918529,
-0.012092785,
0.013908677,
0.0015074861,
-0.021145927,
-0.010132149,
-0.015882472,
0.013263904,
-0.007217511,
-0.016277231,
0.020014284,
-0.0055463645,
-0.011803295,
0.01985638,
0.011309846,
0.0018849744,
-0.011553281,
-0.0044640666,
0.016829893,
0.0059509925,
-0.0154219195,
0.011204577,
-0.019001069,
0.008013609,
0.005049626,
-0.004829219,
-0.0054707024,
0.007947816,
0.01764573,
-0.05195029,
-0.00452986,
-0.033343982,
-0.02921217,
0.03265973,
0.0010880546,
0.021330146,
-0.005243716,
-0.009987404,
0.012632289,
-0.01967216,
-0.004651577,
-0.030870156,
-0.00539833,
0.0051055504,
0.014435022,
0.003980487,
0.028106844,
0.0074412078,
-0.0061417925,
0.03113333,
-0.009382106,
0.019922173,
-0.02601462,
0.022803914,
-0.004549598,
-0.018237868,
0.00809914,
0.01146775,
-0.010046617,
0.014790305,
0.014579767,
-0.0043489286,
0.016750941,
-0.017185178,
-0.020303773,
-0.0040265424,
-0.009217624,
-0.011559861,
0.009171569,
0.006881966,
0.009757128,
0.031843897,
0.0015436723,
-0.026475172,
0.006253641,
0.018882642,
0.00684249,
-0.003973908,
-0.000056027,
-0.014711354,
0.007526739,
0.004154839,
0.03160704,
-0.017132543,
0.0004424591,
0.020632738,
-0.00064970757,
0.015079795,
-0.019251082,
-0.0064543104,
-0.020290615,
-0.021316988,
0.003941011,
0.020382725,
-0.0016111103,
0.021264354,
0.007605691,
-0.0010485786,
0.04394984,
0.0077109598,
0.017211495,
0.03363347,
-0.0148824155,
0.01569825,
-0.010941405,
-0.002611989,
0.030764887,
0.0029195722,
-0.0066845864,
0.00501344,
0.0027962099,
0.010862453,
-0.016593039,
0.020830119,
-0.0024738233,
-0.0018126019,
0.031738628,
0.011829613,
0.044870943,
0.0067701177,
-0.00018864137,
0.0074806837,
-0.0007788267,
-0.021659113,
-0.004635129,
0.028080527,
0.007046449,
-0.008632064,
-0.009717652,
0.018619468,
-0.016343024,
-0.012638869,
0.0072438284,
-0.019895855,
0.003973908,
0.013869201,
0.019895855,
-0.012987573,
0.009954507,
0.0058062477,
-0.010270314,
-0.012665186,
0.018751055,
0.036212564,
-0.0054147784,
-0.025435641,
-0.03847585,
-0.012882303,
-0.0016135776,
0.0005538963,
0.0022780886,
-0.000033436296,
0.0028702272,
0.0025412613,
-0.0129152,
-0.0018849744,
0.032738682,
0.00992819,
0.0021284092,
-0.0017698364,
0.019632682,
-0.0011686513,
-0.012987573,
-0.0042140526,
0.039660126,
0.0037403419,
0.0027879856,
-0.02419873,
-0.008539954,
-0.03989698,
-0.008125457,
0.0049969917,
-0.002256706,
-0.038660068,
0.005924675,
0.0024655992,
-0.0004543841,
0.022474948,
0.012007254,
-0.011007198,
-0.023172356,
-0.013829725,
0.008842602,
-0.002236968,
0.01839577,
0.012599393,
0.008651802,
0.039449587,
-0.01580352,
-0.017935218,
-0.015119271,
-0.023053927,
0.01598774,
-0.012513862,
-0.037159983,
0.005480571,
0.012704662,
0.00016191289,
0.020632738,
0.014408705,
0.008809706,
-0.008243885,
0.01801417,
-0.0009597579,
0.028948996,
-0.0030495136,
0.04452882,
0.037186302,
0.018645786,
-0.006822752,
0.023369735,
0.014513974,
0.015908789,
-0.022251252,
0.0040035145,
0.027106788,
0.0017385846,
0.011230894,
-0.025185626,
-0.031764943,
0.010257156,
0.028448967,
0.0041745766,
0.011730922,
0.015356126,
0.0062437723,
0.013658662,
0.0046384186,
-0.012191475,
-0.015395602,
0.019632682,
-0.0015091309,
0.0076517463,
-0.0028636479,
0.028448967,
-0.031738628,
0.022843389,
-0.040397007,
-0.014237642,
0.006197717,
-0.008743913,
-0.014645561,
0.004075887,
-0.008421526,
0.0004093569,
-0.0029129928,
0.020514311,
-0.013566553,
-0.012355958,
-0.007408311,
-0.0008643578,
-0.013934994,
-0.014619243,
0.009217624,
0.014277118,
-0.030791204,
-0.005539785,
-0.00038879653,
0.01811944,
0.0058259857,
0.0037238935,
0.014158691,
-0.0024162543,
0.055739976,
-0.0051022605,
-0.0019047124,
-0.029501658,
-0.040318057,
-0.011987516,
0.011480909,
0.020211663,
-0.028975314,
0.007928077,
0.0048325085,
-0.003835742,
-0.008368892,
-0.0055299164,
0.003131755,
-0.014895574,
0.026040938,
0.01050717,
0.0047272397,
-0.015658775,
-0.01359287,
-0.022685487,
-0.009849238,
-0.007237249,
-0.007526739,
-0.018566834,
-0.009309734,
-0.004556177,
0.010158466,
-0.008316257,
-0.0046186806,
0.0144218635,
-0.023356577,
0.0005205885,
0.0025856716,
0.0058358544,
0.008033346,
0.027001519,
0.014869257,
0.0041877353,
-0.023343418,
-0.024317157,
-0.0072898837,
0.02765945,
-0.013750773,
-0.03700208,
-0.0030347102,
-0.019606365,
-0.012849406,
-0.002467244,
-0.024606647,
-0.0064312825,
0.018672103,
0.016171962,
-0.015606141,
-0.003306107,
0.014619243,
-0.01984322,
-0.009243941,
0.0009030113,
-0.012684924,
-0.010461114,
0.024738234,
0.014053422,
-0.0045035426,
0.0015518965,
-0.036423102,
-0.02148805,
0.028106844,
-0.014211325,
0.014211325,
-0.0071911938,
-0.0043489286,
-0.032159705,
-0.009526852,
-0.017895743,
-0.046502616,
-0.00092932855,
-0.016343024,
0.031370185,
0.0106848115,
0.020790642,
-0.018198391,
0.025777765,
0.011013777,
-0.0060266545,
0.0018487881,
-0.0009967666,
0.0081846705,
-0.018251026,
0.030449081,
-0.0036087555,
-0.015935106,
0.023146039,
-0.0073622563,
0.0069543384,
0.00896103,
-0.000017026554,
-0.024501378,
0.00510884,
-0.032264974,
-0.020514311,
0.02265917,
-0.014790305,
-0.0016102879,
-0.019290559,
-0.011895406,
0.0019787296,
-0.0026876512,
-0.016619356,
-0.00857285,
0.023632908,
-0.024317157,
0.006039813,
-0.020974863,
0.01319811,
-0.0115335435,
-0.03450194,
-0.0077504357,
-0.0016958191,
0.019132655,
0.011336164,
0.00005391956,
0.0030133273,
0.013553394,
0.0018306951,
-0.001537093,
-0.01069797,
-0.017658887,
-0.02061958,
-0.022224935,
-0.0058555924,
-0.013553394,
-0.021080133,
-0.026106732,
-0.0048357984,
0.014632402,
-0.0032995276,
0.01685621,
-0.016211437,
-0.0031350446,
0.0522661,
-0.0042568184,
0.022185458,
-0.03381769,
0.009303154,
0.0074741044,
0.017579935,
-0.03247551,
-0.018264186,
-0.011869089,
0.0041943146,
0.043291908,
0.017711522,
-0.00886892,
-0.011507226,
-0.0020511022,
0.007388573,
-0.0039081145,
-0.04239712,
0.002709034,
0.0032715655,
-0.013244166,
-0.015382444,
-0.017474666,
-0.023277625,
-0.0021448575,
-0.01880369,
-0.0042831358,
-0.009263678,
-0.012737558,
-0.016724624,
0.035133556,
-0.0010362425,
0.017803634,
-0.002582382,
-0.009618962,
0.009908452,
-0.021672271,
0.016829893,
-0.015092954,
-0.008158353,
-0.006039813,
-0.011809874,
0.0101847835,
0.005079233,
0.004171287,
-0.0010082804,
-0.019158972,
0.0012360893,
0.03910746,
-0.012382275,
-0.0011694736,
0.026909407,
0.012994152,
-0.025554068,
0.0066352417,
-0.0037271832,
0.006631952,
-0.018185234,
-0.010257156,
0.02418557,
0.0033028172,
-0.0101847835,
-0.0000066692687,
-0.027238375,
-0.0047568465,
-0.030028004,
-0.008243885,
-0.0031185965,
-0.027580498,
-0.00799387,
0.005750323,
0.014685037,
0.01879053,
0.0033357139,
0.006579317,
-0.008164933,
0.035738852,
-0.029527975,
0.005036467,
0.019198447,
0.009322893,
-0.02573829,
0.020172186,
-0.016079852,
-0.038186356,
0.008230726,
-0.0039245626,
-0.034449305,
-0.011770398,
0.0072240904,
0.012777034,
0.009816341,
-0.016224597,
0.018843165,
0.007928077,
0.022896023,
0.0027419305,
-0.019290559,
0.007197773,
-0.022448631,
0.0031120172,
0.02371186,
-0.03529146,
0.0025675786,
0.011303267,
-0.023501322,
0.008013609,
-0.003973908,
-0.0029129928,
-0.027817354,
-0.002102092,
-0.017750999,
-0.001985309,
-0.023251308,
-0.003131755,
-0.016145645,
0.022461789,
-0.0053818817,
-0.016316706,
-0.013500759,
-0.015092954,
0.011961199,
-0.000043716478,
-0.014079739,
0.0029771412,
0.000022140945,
-0.024619805,
-0.024132935,
0.0012031926,
-0.026738346,
0.020303773,
0.01685621,
-0.004809481,
-0.03284395,
0.0065201037,
-0.052976664,
-0.002524813,
0.0021465023,
-0.015777202,
0.010750605,
0.01985638,
0.015158747,
0.007954394,
0.007842546,
0.018606309,
-0.004589074,
-0.025659338,
0.019093178,
-0.007335939,
0.01697464,
0.025790924,
-0.03308081,
-0.019487938,
0.04542361,
-0.02755418,
-0.005348985,
0.024725074,
-0.02640938,
0.027975257,
-0.006177979,
0.010790081,
0.00953343,
0.012415172,
0.025501434,
-0.025172468,
0.001965571,
0.013737614,
-0.02043536,
-0.014487657,
-0.0039377213,
-0.008303098,
0.0054016197,
0.0221723,
0.0043686666,
-0.03894956,
0.016619356,
0.004789743,
0.02438295,
0.00033513398,
-0.010171625,
0.0018274054,
0.0042765564,
-0.0035890175,
-0.019830063,
-0.015632458,
-0.020580105,
0.0066747176,
-0.009566328,
0.0005719894,
0.0020001126,
-0.007605691,
-0.0036515212,
-0.024725074,
0.0200406,
-0.0064411517,
-0.01493505,
-0.025685655,
0.021672271,
0.008342574,
-0.026646236,
-0.005845723,
-0.00016756699,
-0.016553562,
-0.018277343,
0.0010000563,
0.017198335,
-0.015053478,
-0.0101847835,
-0.005743744,
0.0037535005,
0.009526852,
0.0018257606,
-0.006947759,
-0.033291347,
0.0034771692,
0.19759005,
-0.028264748,
-0.0027830512,
0.014908733,
-0.007355677,
0.0019145813,
0.0054970197,
-0.022014396,
0.0037995558,
-0.0033077518,
0.016290389,
0.0015741016,
-0.02034325,
-0.004345639,
0.004513412,
0.011888826,
-0.022685487,
0.0023060506,
0.0008651802,
0.018251026,
0.010783501,
-0.009993983,
0.013737614,
0.009546589,
0.057266377,
-0.011967778,
-0.0075727943,
0.00395088,
0.0047075017,
0.016724624,
-0.014685037,
0.019540573,
0.0011456236,
0.018935274,
0.004651577,
0.0031366895,
-0.0027748272,
0.009020244,
0.018106282,
0.014435022,
0.0033603862,
-0.01107957,
0.005865461,
-0.012369117,
0.0011949685,
0.020856436,
0.014408705,
-0.032633413,
-0.010480853,
0.0010683166,
-0.02784367,
0.01947478,
-0.009072878,
0.013711297,
0.0028027892,
-0.0052601644,
0.0014877481,
0.012941517,
-0.0014926826,
-0.0029574032,
-0.03737052,
-0.0093360515,
-0.018593151,
0.015685093,
-0.008664961,
0.020066917,
-0.0129152,
0.007960974,
0.0080662435,
-0.034449305,
-0.015119271,
0.024106618,
-0.01513243,
-0.000078077996,
-0.0075991116,
-0.0037469212,
0.013336277,
0.012171737,
0.03660732,
0.009132093,
0.006043103,
0.017066749,
-0.034659844,
-0.0044476185,
-0.01484294,
-0.020382725,
0.018422088,
0.019514255,
-0.011099309,
0.020514311,
0.01763257,
-0.0015321585,
-0.015527189,
-0.0032534725,
0.0062602204,
-0.017487826,
0.00953343,
-0.0030100376,
-0.013790249,
-0.020093234,
-0.014856098,
0.06779329,
0.034186132,
0.009296576,
-0.009500534,
0.013869201,
-0.015764045,
0.023159197,
-0.0063622,
-0.011296688,
-0.0061154757,
-0.01792206,
0.010770342,
-0.00886892,
-0.028317383,
0.01021768,
0.014395546,
-0.023869764,
0.038975876,
-0.0057667717,
-0.017237812,
-0.017724682,
0.00076566805,
0.034186132,
-0.0011818099,
0.013816566,
-0.01686937,
-0.008711016,
0.014342912,
-0.029291121,
-0.0064904965,
0.028501602,
-0.0030412895,
0.023725018,
0.00049139274,
-0.027738402,
0.011625654,
-0.0025396165,
-0.030475399,
0.014435022,
-0.010329528,
-0.027501546,
0.013908677,
0.014027105,
-0.002131699,
0.0004942712,
0.009849238,
0.01735624,
-0.012796773,
0.016053535,
0.026369903,
-0.012961255,
-0.0053950404,
-0.010678232,
0.016829893,
0.00048193499,
-0.010586121,
-0.01734308,
0.0123033235,
0.014777146,
-0.015842997,
0.011112467,
0.009053141,
-0.0138428835,
-0.0076122703,
0.018869482,
-0.1644303,
0.030028004,
0.02429084,
-0.021343306,
0.027685767,
0.007868864,
0.004865405,
0.009711073,
-0.020580105,
0.014250801,
0.034054548,
-0.010316369,
-0.029633244,
-0.027527863,
-0.0028751616,
-0.0017188466,
-0.011066412,
0.017000956,
0.017672047,
-0.008132036,
0.009816341,
-0.018343138,
0.0073293597,
-0.011875668,
0.023619749,
0.008178092,
0.0017106225,
-0.025264578,
0.0038785075,
-0.012566496,
-0.01050059,
0.009020244,
0.012921779,
-0.0058819097,
0.012480965,
0.017119383,
0.003970618,
0.0112243155,
0.008283361,
0.022974975,
0.025935668,
0.025869876,
-0.022238092,
0.017579935,
-0.0040725973,
0.011507226,
-0.00035631115,
0.0013240876,
0.019303717,
-0.022382837,
0.024396108,
-0.014040263,
-0.009434741,
0.03671259,
0.038028453,
0.009724231,
0.0031564275,
0.011553281,
0.017829949,
-0.014974526,
-0.0024442163,
-0.0058753304,
0.015685093,
-0.013283642,
-0.01011241,
-0.008901817,
-0.0062404824,
0.013244166,
-0.021066975,
0.007158297,
-0.014369229,
-0.028080527,
0.014895574,
-0.023948714,
0.021672271,
0.03613361,
0.023646066,
-0.010776922,
0.0050726538,
0.006322724,
-0.000054176566,
-0.0032715655,
-0.011704605,
-0.017856266,
-0.027475229,
0.0036975762,
-0.0020132712,
0.026738346,
-0.010494011,
-0.009007085,
0.03294922,
-0.0400812,
-0.004223922,
-0.015290334,
0.019001069,
0.029370073,
0.00007129307,
-0.017579935,
-0.015474554,
0.019487938,
0.018830007,
-0.0089149745,
-0.001671969,
0.00007715278,
-0.011336164,
-0.0062766685,
-0.011921723,
-0.00039188057,
0.01513243,
0.0041482598,
-0.014908733,
0.002516589,
0.0018635916,
0.020672215,
-0.024251364,
0.018961592,
0.007171456,
0.0052766125,
0.0055858404,
-0.024277681,
0.08310994,
0.013527077,
0.005283192,
0.026633076,
-0.018001013,
-0.036738906,
-0.14558713,
-0.009309734,
0.02072485,
0.00578322,
-0.00000589183,
0.013606029,
-0.006158241,
0.0028587133,
-0.00819125,
0.025646178,
-0.037054714,
-0.0076517463,
-0.017172018,
-0.018053647,
-0.00089067506,
0.011316426,
0.004470646,
-0.01569825,
-0.01484294,
0.024330316,
-0.010375584,
-0.025159309,
-0.011244053,
0.0037337625,
0.016277231,
-0.00054279366,
-0.02292234,
0.026080415,
-0.0005707558,
0.004799612,
-0.0007348275,
0.005358854,
0.012382275,
-0.010915088,
-0.015619299,
-0.013059945,
0.0006949404,
-0.0014902154,
0.0200406,
-0.00481935,
0.0031794552,
0.020001125,
0.011283529,
-0.005849013,
-0.0057207164,
0.012270426,
-0.015435078,
0.010375584,
0.021159085,
0.00925052,
-0.013579711,
-0.018290503,
-0.03844953,
-0.04192341,
0.023080245,
-0.0050923917,
-0.031554405,
0.01831682,
-0.009842658,
0.014250801,
0.005579261,
0.0058062477,
-0.008599168,
0.010151886,
0.03592307,
-0.0006492964,
-0.021817015,
-0.024277681,
0.038581118,
-0.011290109,
0.01618512,
-0.014277118,
-0.0074741044,
0.00070398697,
-0.01946162,
0.0053621437,
-0.013908677,
-0.01840893,
-0.008743913,
-0.014013946,
0.012757297,
-0.020303773,
0.0023192093,
-0.008967609,
0.0342914,
0.0045989426,
-0.0045430185,
0.0027156132,
0.02215914,
-0.014408705,
-0.017658887,
0.021159085,
0.015527189,
0.004056149,
-0.006154951,
0.0016440069,
-0.006822752,
-0.0049114604,
0.007934657,
0.02968588,
-0.033133443,
0.012316482,
-0.043028735,
0.017514143,
-0.004750267,
0.004263398,
0.011895406,
-0.03237024,
0.005020019,
-0.028106844,
0.019790586,
0.0117243435,
-0.0026860062,
0.012980993,
0.00037502107,
0.022619693,
-0.019580048,
-0.023751335,
0.024685599,
-0.0027106788,
0.0082965195,
0.030870156,
-0.010790081,
-0.019751111,
0.014895574,
0.011395378,
-0.015921948,
0.022435471,
-0.041370746,
0.0000449758,
-0.00973081,
0.014474498,
0.010921666,
-0.028291065,
-0.0052404264,
-0.0025429062,
-0.017237812,
-0.033896644,
-0.0031218862,
0.035501998,
0.0100203,
0.016671991,
-0.018106282,
-0.023935556,
0.007888601,
-0.009125513,
-0.0059213857,
-0.012329641,
-0.02871214,
0.0039837766,
0.008533374,
-0.014408705,
0.013869201,
0.015027161,
-0.00014710943,
-0.03102806,
0.0024310579,
-0.00065381965,
0.004398274,
-0.012290165,
-0.014632402,
-0.030949108,
0.02177754,
0.024053983,
0.010901929,
-0.021711746,
0.023869764,
-0.02235652,
-0.051292356,
0.013277062,
0.0061911377,
0.0030495136,
-0.028922679,
0.016790418,
0.0065003657,
-0.0015773913,
-0.0070332903,
0.008664961,
-0.025790924,
-0.00003824228,
-0.010079514,
-0.00034870382,
0.019711634,
-0.005743744,
-0.0034344036,
0.009678176,
0.023303943,
-0.008980768,
-0.007697801,
0.0027040995,
0.008355733,
-0.009961086,
0.011428274,
0.017461509,
0.00983608,
0.0070003937,
0.012467806,
0.0096387,
0.0038390316,
0.002179399,
0.003980487,
0.018948434,
0.010908508,
0.008362312,
0.014250801,
-0.024409268,
-0.011250633,
0.0054016197,
-0.040712815,
-0.04695001,
-0.025159309,
0.0041877353,
-0.00530293,
0.007974133,
0.022409154,
-0.0077701737,
-0.010138728,
0.005569392,
-0.013290221,
0.0018487881,
-0.012855986,
0.009428162,
0.013513918,
0.026948884,
-0.020777484,
-0.025172468,
0.006194427,
0.00038221723,
0.0053325365,
-0.0070398697,
0.024896137,
-0.0138823595,
-0.00046343065,
-0.016132487,
-0.014079739,
-0.0026366615,
-0.011882247,
-0.02688309,
-0.0051055504,
0.012171737,
-0.036370467,
0.07079346,
0.00983608,
-0.016935162,
-0.0027929202,
-0.029527975,
0.034528255,
-0.015106113,
0.018474722,
-0.052213464,
-0.04010752,
0.016816735,
0.0018635916,
0.016790418,
-0.03823899,
-0.017948378,
0.015106113,
-0.011421694,
0.016264072,
0.00073770597,
-0.00934263,
0.0024310579,
-0.025817242,
0.0020675506,
0.012474386,
-0.019395828,
0.0027649582,
0.018290503,
0.018527357,
0.0022139403,
-0.020606421,
0.022790756,
-0.012224372,
-0.03392296,
0.00089560956,
-0.0010617373,
-0.015829837,
-0.015895631,
-0.040712815,
-0.01417185,
0.029791148,
-0.0025577096,
0.0154613955,
-0.030528033,
-0.034659844,
-0.020290615,
0.011000618,
-0.02669887,
-0.014895574,
0.0009852528
] |
BACKGROUND Paralysis or amputation of an arm results in the loss of the ability to orient the hand and grasp, manipulate, and carry objects, functions that are essential for activities of daily living. Brain-machine interfaces could provide a solution to restoring many of these lost functions. We therefore tested whether an individual with tetraplegia could rapidly achieve neurological control of a high-performance prosthetic limb using this type of an interface. METHODS We implanted two 96-channel intracortical microelectrodes in the motor cortex of a 52-year-old individual with tetraplegia. Brain-machine-interface training was done for 13 weeks with the | [
-0.020412294,
-0.0110432645,
0.0129451975,
-0.008960514,
-0.010862447,
0.015844977,
-0.0048284987,
0.015469947,
-0.024484036,
-0.011572324,
-0.020613201,
0.03653854,
0.005049498,
0.01396983,
0.0034321852,
-0.00243434,
0.037690416,
0.017532606,
0.0069648246,
-0.0017412062,
-0.00831091,
0.015228856,
0.005226967,
-0.015938733,
-0.020318536,
-0.008993999,
0.002355651,
-0.028609356,
0.0009250158,
0.0013711998,
0.029359413,
-0.011137023,
-0.018912178,
-0.01651467,
-0.019997083,
-0.0051901336,
0.011558929,
-0.0053809965,
0.0007894026,
0.0024946127,
0.028180752,
-0.00045748518,
0.0049389983,
0.0055986475,
-0.014103769,
-0.0007174104,
-0.020211386,
-0.009603421,
-0.040020954,
-0.0010648145,
0.02384113,
0.015804794,
-0.035279516,
0.0005474754,
-0.003140868,
-0.017037032,
-0.004597454,
0.02607791,
0.025207307,
-0.028984385,
0.0037301993,
0.01537619,
-0.016943274,
-0.0067036436,
-0.0022250605,
-0.027256573,
0.0022384543,
-0.0010170988,
0.012268806,
0.010648145,
0.026412757,
0.010172662,
-0.006077479,
-0.012288897,
0.043958757,
0.004741438,
-0.013648377,
-0.019461326,
-0.0014590973,
0.010386964,
0.02063999,
-0.03691357,
-0.014679707,
0.016206611,
0.01647449,
-0.019595265,
-0.00085260504,
-0.0119942315,
0.014130557,
-0.011632596,
-0.0027742102,
-0.006298478,
-0.009583331,
0.0023640222,
-0.014478799,
0.03929768,
-0.016139641,
0.023091072,
-0.008960514,
-0.009462786,
-0.0071255513,
-0.020974837,
-0.03327043,
-0.012201836,
-0.021376655,
-0.009074363,
0.014652919,
-0.0065697045,
0.025019793,
-0.007862215,
-0.022943739,
0.02129629,
0.013728741,
-0.033832975,
0.003559427,
0.015027949,
-0.0026285516,
0.0203989,
0.018068362,
-0.009275271,
0.039029803,
0.0058765705,
-0.0045036967,
0.015014554,
0.003345125,
0.0154967345,
-0.029546928,
0.008485031,
-0.014411829,
0.000707365,
-0.004165501,
-0.008464941,
0.01847018,
0.012576866,
0.009395816,
0.030029109,
-0.014719889,
-0.028395053,
-0.0245644,
-0.021323077,
0.00229203,
-0.011210688,
0.0097038755,
-0.0143716475,
-0.027082453,
0.011739748,
0.023934888,
0.017626364,
0.004121971,
0.003522594,
-0.009556543,
-0.016461095,
0.006522826,
-0.0056957533,
0.00467112,
-0.0007990294,
0.009181513,
0.044494513,
-0.0037904717,
-0.012838047,
-0.021577561,
-0.020586414,
-0.011143719,
-0.012516594,
0.022582104,
0.025368033,
-0.017452244,
-0.006857673,
0.007855519,
0.0002561582,
-0.0037368962,
0.027778935,
-0.024684945,
0.0028813614,
-0.01044054,
0.012228625,
0.0063855387,
0.011786626,
-0.01809515,
-0.01875145,
-0.016742367,
0.024001857,
0.0052236184,
0.011311143,
-0.0016014074,
0.014076982,
0.01741206,
-0.020519445,
0.00043948714,
-0.019220237,
0.019997083,
-0.014920797,
-0.019903325,
-0.0016441004,
-0.6493359,
-0.004329576,
0.019595265,
0.00021911573,
0.013849285,
0.015751218,
0.009328847,
-0.01861751,
0.0047581806,
0.03533309,
0.020412294,
0.009991844,
-0.0018299407,
-0.03495806,
-0.012288897,
-0.0073800352,
-0.0061879787,
-0.014090376,
0.008920333,
-0.00609757,
-0.024832278,
0.009670391,
-0.012529987,
0.012817956,
-0.01847018,
-0.010601266,
0.009328847,
-0.00020478007,
-0.02081411,
0.016313761,
0.00022811475,
0.019755993,
-0.0010145875,
0.00870603,
0.05338806,
-0.0033518218,
-0.02070696,
0.034797333,
-0.0014624457,
0.02177847,
-0.016420914,
-0.004634287,
0.0051265126,
0.0014657942,
-0.014304678,
0.021323077,
-0.0020174552,
-0.010842357,
-0.005029407,
-0.014385042,
0.038654774,
0.01396983,
-0.0030186486,
0.005136558,
0.011177204,
-0.023211617,
0.025756456,
-0.017037032,
0.029868381,
-0.004744787,
0.0026971952,
0.0079760635,
-0.007246096,
-0.027055664,
-0.012570169,
0.018898783,
-0.0025649306,
-0.0034958061,
-0.021202533,
-0.019903325,
0.009529755,
0.015711037,
0.013065743,
0.011739748,
0.009496271,
0.004667772,
0.013152803,
0.011016477,
-0.014920797,
0.015510129,
0.0017060471,
0.0059468886,
-0.024885854,
-0.0061076153,
0.022193681,
-0.0025833473,
-0.00956324,
0.02590379,
0.0042123795,
0.0058029043,
0.03498485,
0.009241787,
-0.008163578,
-0.032493584,
-0.014907403,
0.022180287,
-0.0030655274,
-0.0017730166,
0.003623048,
-0.0027156118,
0.0056823594,
-0.013715346,
0.04066386,
0.013460862,
0.02759142,
0.0020676823,
-0.015911946,
0.02855578,
0.04503027,
-0.015469947,
-0.03450267,
0.0015026274,
0.032841828,
0.006375493,
0.011150416,
-0.026198456,
-0.01285144,
0.005652223,
-0.010011936,
-0.04103889,
0.023077678,
-0.004520439,
0.024845673,
0.00642572,
0.011933959,
0.014251103,
-0.014773464,
-0.014130557,
-0.019072903,
-0.01723794,
-0.0007768458,
0.0013485976,
0.010206147,
-0.00886006,
0.034074064,
0.018630905,
0.018590724,
-0.016929882,
0.0023322117,
-0.014304678,
-0.019072903,
-0.021564169,
0.00837788,
0.00023104466,
-0.011137023,
-0.0274173,
-0.015831582,
0.0012372609,
0.006194676,
-0.025341246,
0.0027340285,
-0.01881842,
0.014920797,
0.0031626332,
0.0203989,
-0.023961674,
-0.022796405,
-0.019005934,
-0.007152339,
-0.032252494,
-0.022434771,
-0.0029901867,
0.00082079455,
0.0065897955,
-0.02043908,
-0.044119485,
0.020666778,
0.023024103,
-0.037074298,
-0.04500348,
0.002809369,
-0.00491221,
-0.0033987004,
-0.0024309917,
-0.034449093,
0.008786394,
0.022595499,
-0.011639293,
0.0031358453,
-0.002871316,
-0.012784471,
0.0058096014,
0.019903325,
0.009603421,
0.012114776,
-0.008130093,
0.020666778,
-0.007165733,
-0.026854755,
0.03037735,
0.010098996,
0.03270789,
0.00047129762,
0.004888771,
-0.00010531995,
0.009188211,
0.005300633,
0.018657694,
-0.0041989856,
0.012128171,
0.028234327,
-0.012483109,
0.012844743,
0.0070853694,
0.02769857,
-0.0118201105,
0.013018864,
-0.017104002,
0.018938964,
-0.010159268,
-0.013139409,
-0.011692869,
0.009998541,
-0.02868972,
-0.0046376353,
0.0126840165,
-0.0073063686,
0.006840931,
-0.020974837,
-0.00982442,
0.019555084,
0.009911481,
0.0032630872,
0.016220005,
0.006670159,
0.01905951,
0.00609757,
0.024792096,
0.0012858137,
-0.012181746,
0.010460631,
0.03131492,
0.009208302,
0.008585486,
0.01713079,
0.011210688,
-0.0065830983,
-0.0018332892,
0.04961098,
0.014251103,
0.004316182,
0.02645294,
0.006877764,
-0.0076813977,
0.028662931,
0.006311872,
0.019139873,
0.007815337,
0.010554388,
0.015510129,
-0.020238172,
-0.015617279,
-0.021832045,
0.0024510825,
-0.00039595697,
-0.012898319,
-0.0053508603,
0.0039712894,
0.028314691,
0.025461791,
0.034663394,
0.024845673,
0.002511355,
-0.017037032,
0.020064052,
-0.0032831782,
0.012697411,
-0.0018182211,
0.0068174917,
-0.016206611,
-0.03351152,
-0.016889699,
-0.012268806,
-0.035922423,
0.012985379,
-0.008243942,
0.007768458,
0.005729238,
0.008284123,
0.009951662,
-0.026600271,
-0.055022113,
0.015402977,
0.004470212,
-0.0027390511,
-0.0052236184,
-0.016876306,
0.02903796,
-0.0018349633,
-0.014076982,
-0.0050193616,
0.025877003,
0.0056421775,
0.016019097,
-0.001104159,
0.0120812915,
0.03656533,
0.011538839,
-0.0018215695,
-0.029305838,
0.005689056,
0.007949276,
-0.022032954,
-0.011297749,
0.020345325,
0.012061201,
-0.033886548,
-0.03870835,
-0.0076077315,
-0.02570288,
0.030913105,
0.00070401654,
0.01603249,
-0.020171203,
0.018014787,
0.0068375827,
-0.006375493,
0.018711269,
0.017117396,
0.019072903,
-0.02026496,
-0.030805955,
-0.0100052385,
0.007949276,
0.049423467,
0.025796639,
-0.006509432,
0.018135332,
-0.014572556,
-0.018376421,
-0.017987998,
-0.048807345,
0.030350562,
0.003438882,
0.004848589,
0.0073063686,
0.0055082384,
-0.0030571562,
0.02480549,
0.007540762,
0.02129629,
-0.021738289,
-0.012242018,
-0.0010346783,
0.009020787,
0.008866757,
0.021577561,
0.028287902,
0.009590028,
-0.0016265209,
0.0011535491,
0.015269038,
-0.0017730166,
-0.019889932,
-0.010313298,
0.007969366,
0.0054211784,
0.008036336,
-0.009871299,
-0.0041085766,
-0.0013661771,
0.016541459,
0.035413455,
0.022716044,
0.012978682,
0.01627358,
-0.0060172067,
-0.0143716475,
0.0193006,
-0.020050658,
-0.010869144,
0.0024644763,
-0.018871995,
-0.014264496,
0.042405065,
-0.0018952359,
-0.008002851,
-0.020064052,
0.018255876,
0.005729238,
-0.0020475914,
0.009931572,
-0.014907403,
0.0139832245,
0.016300367,
-0.00541783,
0.019287206,
0.0015896877,
-0.0032848523,
-0.027886085,
-0.025997547,
0.007989457,
-0.018363027,
0.0020141066,
0.0036397905,
-0.012148261,
-0.018657694,
0.0030102774,
0.012596956,
0.0030471107,
0.030591652,
-0.009074363,
-0.011049962,
0.012811259,
0.011445082,
-0.025059974,
0.005441269,
-0.020934654,
0.01875145,
0.013541226,
0.0016842821,
-0.0077014887,
-0.011619203,
0.016019097,
0.0396995,
-0.005545072,
0.022916952,
0.028261114,
0.0030370653,
0.007393429,
0.020974837,
0.005300633,
-0.0067538708,
-0.019595265,
0.011498657,
-0.068898186,
-0.014532374,
-0.045967843,
-0.004399894,
-0.0060406458,
0.007902397,
0.0051599974,
-0.0164477,
-0.014987767,
0.02432331,
0.008331002,
0.018778238,
-0.008605576,
0.023184828,
0.015094917,
0.02263568,
0.008886849,
0.03144886,
-0.00070652785,
-0.0015135099,
-0.040342405,
0.029814806,
0.012670623,
-0.009476179,
0.00053450005,
0.013460862,
-0.016220005,
-0.035011638,
0.015536916,
0.0038741836,
0.01236926,
0.0026838013,
-0.0074202167,
-0.027283361,
-0.019260418,
-0.0076947915,
-0.0026804528,
-0.0068844613,
-0.0122822,
-0.010058814,
0.0035560788,
0.002461128,
-0.014264496,
0.010962902,
-0.035092,
0.0041420613,
0.028502205,
-0.0049055135,
0.02783251,
-0.017827272,
0.013628286,
-0.020800715,
0.019876538,
-0.027618207,
-0.036029574,
0.01348765,
-0.02070696,
0.036833208,
0.015456553,
0.044226635,
-0.01723794,
-0.004259258,
0.028582567,
0.001457423,
0.0016114528,
0.0027524452,
-0.004121971,
-0.004353015,
0.016246792,
0.005079634,
0.021336472,
0.010976296,
0.0053508603,
-0.007848822,
0.010494116,
0.004888771,
-0.0023857872,
-0.0044869543,
-0.027778935,
-0.0029583762,
0.0047514834,
-0.008183668,
-0.0021848788,
-0.04138713,
-0.010279813,
0.03656533,
0.0010371896,
-0.00021974357,
0.010561084,
0.01386268,
-0.006797401,
-0.0041822433,
0.00982442,
0.016246792,
-0.010319995,
-0.02136326,
-0.014130557,
0.0073398533,
0.008639061,
0.011284355,
-0.010628054,
0.005843086,
-0.010561084,
-0.013768923,
0.019139873,
-0.011411597,
0.015175281,
-0.039163742,
-0.0041688494,
-0.019153267,
-0.017425455,
-0.0029617248,
-0.008471637,
0.0030086034,
0.025327852,
-0.019769387,
0.034583032,
-0.0328954,
-0.008518516,
0.02184544,
-0.032386433,
0.03873514,
-0.01555031,
0.019702418,
0.017639758,
-0.0009844512,
-0.006211418,
-0.019822963,
0.02184544,
0.008813182,
0.023452707,
0.03506521,
-0.015911946,
-0.03412764,
0.006465902,
0.013742135,
-0.021912409,
-0.056843683,
0.008324305,
0.02548858,
-0.0012464692,
0.0020810761,
-0.0034489275,
-0.017626364,
0.015952127,
-0.031663164,
-0.017211152,
-0.00822385,
-0.027162816,
-0.007319763,
0.0032798296,
-0.017170971,
-0.0046510296,
-0.0027976495,
0.010607963,
0.0017512515,
0.012529987,
-0.020720353,
0.017880848,
0.025100157,
0.02033193,
0.00060607365,
0.008043033,
-0.019662235,
-0.009148029,
-0.0058531314,
-0.006298478,
0.0046744687,
0.030886319,
-0.005541723,
-0.0014666313,
0.0139832245,
0.0068643703,
0.017023638,
-0.017090607,
-0.002985164,
-0.0016499602,
-0.0033200113,
0.003176027,
0.026466332,
0.015202069,
-0.031234559,
-0.01765315,
-0.028368266,
-0.0130322585,
-0.029573716,
-0.013768923,
-0.007875609,
-0.029680867,
-0.0042123795,
-0.005377648,
0.010500812,
-0.008552001,
0.0139832245,
-0.011840202,
0.013594802,
0.018898783,
-0.014532374,
0.020064052,
-0.0022853331,
0.026158273,
0.0020894473,
0.013347015,
-0.0052872393,
-0.013300136,
0.0076613068,
-0.027511057,
-0.039270896,
-0.017934423,
-0.008156881,
-0.0006805772,
-0.0079760635,
-0.023573251,
0.020559626,
-0.014076982,
0.01331353,
-0.0048218016,
-0.034315154,
-0.017546,
-0.012496502,
-0.003127474,
0.016528064,
-0.020720353,
-0.0053374665,
-0.004406591,
0.0114049,
0.009630209,
-0.03994059,
-0.008940424,
-0.002392484,
0.018604118,
-0.020720353,
-0.0068442794,
-0.011933959,
-0.00205094,
-0.029627291,
-0.0128581375,
-0.009603421,
-0.01943454,
0.0027758845,
-0.010313298,
0.0138091035,
0.011572324,
-0.01730491,
-0.0015185326,
0.0058129495,
-0.021805258,
-0.03519915,
0.0074804896,
-0.030939894,
0.02463137,
-0.01778709,
-0.004942347,
-0.014733283,
-0.015630674,
-0.062415544,
0.0009358983,
-0.0018584027,
0.007507277,
0.040154893,
0.022474952,
0.020720353,
0.012308988,
0.009181513,
0.0061879787,
0.0028127176,
-0.02656009,
0.01978278,
-0.0071858237,
-0.02164453,
-0.004557272,
-0.050494976,
-0.014505587,
0.021122169,
-0.016353944,
0.0012280525,
0.025086762,
0.0028595962,
-0.015697643,
0.020586414,
0.020104233,
0.008786394,
0.004795014,
-0.009435997,
-0.03000232,
-0.008210457,
-0.001287488,
-0.00243434,
-0.004265955,
-0.0019689023,
0.01936757,
0.0056723137,
-0.008853364,
-0.0274173,
-0.022287438,
0.015228856,
-0.02759142,
0.0324668,
-0.0026051123,
0.00804973,
0.01565746,
0.0036263966,
0.016554853,
-0.036136724,
0.012704108,
-0.005237012,
0.009569936,
0.0074670953,
-0.031073833,
-0.007781852,
-0.010775387,
0.02548858,
-0.033725824,
-0.00039595697,
-0.014465405,
0.0020208037,
-0.0040416075,
0.018563936,
0.026305607,
-0.016246792,
-0.016420914,
0.007668004,
-0.006489341,
-0.022756224,
-0.032038193,
0.0053676027,
-0.040101316,
-0.0069447337,
-0.0064290687,
-0.0064424626,
0.0011585718,
0.026171668,
0.0048720287,
0.002603438,
0.016528064,
0.1776566,
-0.03436873,
-0.00076638185,
0.0029014521,
-0.009985147,
0.031556014,
0.0106548425,
-0.00031224513,
-0.010212843,
-0.009060969,
-0.01346756,
-0.015965521,
-0.03694036,
-0.004426682,
0.015751218,
-0.00015319265,
0.0033501475,
-0.01434486,
-0.0115187485,
0.0015863392,
0.0073532476,
-0.015871763,
0.006650068,
-0.0014264496,
0.04393197,
0.012951895,
-0.025689486,
0.001598896,
0.0193006,
0.021323077,
-0.02267586,
0.012503199,
0.02068017,
-0.0058531314,
0.0030872924,
0.0034187913,
0.0033635416,
-0.015818188,
-0.008183668,
0.0009752429,
0.01548334,
0.01379571,
0.005930146,
-0.0016441004,
0.00925518,
0.012355867,
0.010822265,
-0.025863608,
0.005059543,
-0.0011769884,
-0.030404137,
-0.0081033055,
0.020305142,
0.015282433,
-0.002844528,
-0.014090376,
0.031422075,
0.021015018,
0.028716506,
0.019019328,
-0.021256108,
0.014907403,
-0.012509896,
0.059361733,
-0.018912178,
0.018590724,
0.010594569,
0.019742599,
0.004031562,
-0.016193217,
-0.015644068,
-0.0046141963,
-0.021001624,
0.020197991,
-0.018483574,
-0.04792335,
0.04575354,
0.00956324,
0.015831582,
0.012463017,
0.013889467,
-0.012181746,
0.0064223716,
-0.010427146,
-0.041788947,
-0.03230607,
0.040985312,
0.007614428,
-0.010942811,
-0.009288665,
0.014358253,
-0.027256573,
0.0044969996,
-0.007795246,
-0.00032794112,
0.020854292,
0.0044534695,
-0.009944966,
-0.009764148,
0.00273068,
-0.025100157,
0.044601664,
0.012536684,
-0.0042190766,
-0.003502503,
0.017090607,
0.0023087724,
0.0372886,
0.008632364,
-0.0045807115,
-0.002985164,
-0.014063588,
0.004121971,
0.0009727315,
0.013447469,
0.013387197,
-0.0016424261,
-0.008250638,
-0.00008245616,
-0.0019504857,
0.016126247,
-0.028395053,
-0.008230547,
0.012757683,
-0.0041152737,
-0.015737824,
-0.027216392,
0.0009919852,
-0.004952392,
-0.013541226,
-0.019635448,
-0.026680635,
0.0062951297,
-0.014251103,
-0.020077446,
0.007949276,
0.011284355,
-0.016327156,
-0.015711037,
0.008873454,
0.0074804896,
-0.0030035805,
-0.008451547,
-0.0077885487,
0.014920797,
-0.012047807,
0.0073800352,
0.025301065,
-0.008163578,
-0.018229088,
-0.025582336,
-0.0049892254,
-0.0027423997,
-0.008183668,
0.0217115,
0.0128581375,
-0.014050194,
-0.027537845,
-0.011123628,
0.012771077,
-0.025287671,
0.002574976,
0.012971986,
-0.013501044,
-0.0090542715,
0.0098779965,
-0.16994172,
-0.0010489093,
0.036859993,
-0.051861156,
0.041708585,
0.0016097785,
0.023439312,
-0.031047044,
-0.017144183,
-0.007433611,
-0.004399894,
-0.00038423733,
-0.00822385,
-0.024417067,
0.0014590973,
-0.0038005172,
-0.012416139,
0.03000232,
0.026399363,
0.0035761695,
-0.019796174,
-0.021577561,
0.028770084,
0.0018851905,
0.030216623,
-0.010253025,
-0.006542917,
-0.000788984,
0.043476578,
-0.037985083,
0.0035929119,
-0.0035460333,
0.03870835,
-0.02487246,
0.020037264,
-0.001358643,
0.0024711734,
0.008558698,
-0.015336008,
0.027778935,
-0.013045652,
0.026908332,
-0.014090376,
-0.022662468,
0.014505587,
0.011786626,
0.0034891092,
-0.035038427,
0.0070719756,
0.010828963,
0.011371415,
0.004805059,
0.0074537015,
0.007299672,
0.022890164,
0.016608428,
0.010333389,
-0.0023539767,
-0.0026000894,
-0.0014423549,
0.012596956,
0.0016901419,
0.016903093,
-0.0026134835,
-0.014304678,
-0.025341246,
-0.004697908,
-0.00059895817,
-0.019447934,
0.0071121575,
-0.037422538,
0.0026921725,
0.0065563107,
-0.0145457685,
0.016836124,
0.006616583,
0.006706992,
0.0040717437,
0.002009084,
0.012838047,
0.0039913803,
0.017385274,
-0.0138091035,
-0.014264496,
0.001223867,
0.004845241,
0.013755528,
0.0073331567,
-0.0088399695,
-0.018309452,
0.025234096,
-0.034234792,
0.008391274,
-0.006529523,
0.009221695,
0.030404137,
0.009603421,
-0.03351152,
0.016903093,
-0.020224778,
0.00027143562,
0.021376655,
-0.015041342,
0.0062649935,
0.028127177,
-0.008297517,
-0.0328954,
0.0024845672,
0.0013184614,
0.0007764273,
-0.0016323808,
-0.021872228,
0.010293207,
0.018925572,
0.009154726,
0.014143951,
0.011920565,
-0.0056421775,
0.0044132876,
-0.014853828,
0.045458876,
0.00585648,
-0.018523755,
-0.0077885487,
-0.009389119,
-0.010641448,
-0.13415323,
-0.02793966,
0.02057302,
0.018363027,
-0.00394785,
0.016595034,
-0.01291841,
0.02177847,
-0.028475417,
0.020519445,
-0.034074064,
-0.036752842,
0.007915791,
-0.009134635,
0.026359182,
-0.011920565,
0.0049825283,
-0.0053173755,
0.0043798033,
0.033190068,
0.005709147,
-0.0002636923,
0.0048552863,
-0.026653847,
0.0038105627,
-0.0027641647,
-0.019836355,
0.022983922,
0.0006458368,
0.007815337,
0.015295826,
-0.026814574,
0.032734673,
0.011016477,
0.0015252295,
-0.0023740677,
-0.005501542,
-0.012623744,
0.025140338,
-0.01772012,
0.00491221,
0.0044032424,
0.025984153,
-0.007527368,
0.0074537015,
-0.0113915065,
-0.023211617,
-0.006740477,
0.009536452,
-0.017666545,
-0.024216158,
-0.016220005,
-0.021443622,
0.015778007,
0.009248483,
-0.005427875,
0.008766303,
0.010648145,
-0.016970063,
0.0077885487,
-0.0002879687,
0.004557272,
-0.008257335,
0.014010012,
0.0036531843,
-0.012583563,
-0.027457481,
-0.04864662,
0.016782548,
-0.0002908986,
0.01572443,
0.021631138,
0.011947352,
-0.012596956,
-0.052396912,
-0.007279581,
0.0057828133,
-0.015577097,
0.010688327,
0.015510129,
-0.031288136,
-0.015992308,
0.0094426945,
0.011411597,
-0.0009099476,
0.0025230746,
0.0035560788,
0.014090376,
0.015952127,
-0.0042760004,
0.0051599974,
0.048378743,
-0.0073331567,
-0.01530922,
-0.0126438355,
-0.009998541,
-0.0074670953,
0.0026017637,
0.013186288,
0.028850446,
-0.008257335,
-0.014117164,
-0.0515397,
0.035654545,
0.009308755,
-0.03921732,
0.016220005,
0.0035761695,
0.00064541824,
0.007674701,
-0.008331002,
0.012409442,
-0.007447005,
0.0036330936,
-0.0062281606,
-0.0064190235,
-0.035038427,
-0.008766303,
0.035949208,
-0.014304678,
0.014693101,
0.004597454,
0.0062515996,
-0.0068241884,
0.015630674,
0.028395053,
-0.025341246,
-0.0100922985,
-0.021523986,
0.027752146,
0.0005596136,
-0.013460862,
0.00370676,
-0.019153267,
-0.023050891,
0.0053943903,
0.006857673,
-0.0056924047,
0.0056823594,
0.024229553,
0.0061377515,
0.049316317,
0.0010849054,
-0.020050658,
0.014920797,
-0.017907634,
0.018309452,
0.01019945,
-0.007192521,
0.005093028,
0.0048084077,
-0.009248483,
0.004252561,
0.0012506548,
-0.007406823,
-0.032225706,
-0.016072672,
-0.004450121,
0.0009752429,
0.0060942215,
0.012958592,
-0.015148493,
0.020934654,
0.014264496,
-0.0073130657,
-0.0055584656,
0.006897855,
0.005250406,
-0.006763916,
0.02026496,
-0.014170739,
-0.0063587506,
-0.024001857,
0.00019075834,
0.0056555714,
-0.009596724,
0.029627291,
0.006951431,
0.0055785566,
0.025408216,
-0.010487419,
0.0050461493,
0.02177847,
-0.011304446,
-0.039404836,
-0.003897623,
0.02246156,
0.010474024,
-0.022220468,
0.023479495,
-0.013233166,
-0.01489401,
0.006593144,
0.0062214634,
-0.018054968,
0.0315828,
-0.0051265126,
0.008913636,
-0.00541783,
-0.0034857607,
0.017010244,
0.0077885487,
-0.0034070716,
0.001690979,
0.0003681228,
-0.02046587,
-0.0047648777,
0.007614428,
-0.036351025,
-0.02572967,
-0.01506813,
0.0068107946,
0.03482412,
0.03270789,
0.008016245,
-0.00026704074,
-0.015027949,
0.0129451975,
-0.011003084,
-0.02342592,
-0.02978802,
0.0065161292,
0.028100388,
0.017532606,
0.0031375196,
-0.018135332,
0.015362795,
0.018697875,
0.028770084,
-0.015670855,
0.012483109,
0.007132248,
0.019287206,
0.0023271888,
-0.040610284,
-0.029814806,
-0.0032731327,
-0.02769857,
-0.011873687,
0.00804973,
-0.004741438,
0.08363147,
-0.004563969,
-0.009851209,
-0.004111925,
-0.024135796,
-0.012268806,
-0.012101383,
0.013614893,
-0.009127938,
-0.029171899,
0.010413752,
-0.01816212,
0.026359182,
-0.030939894,
-0.016394125,
0.0075675496,
-0.023144647,
0.03581527,
-0.0072728842,
-0.0071255513,
0.012308988,
0.0046878625,
0.017023638,
-0.0011828482,
-0.013253258,
0.010581176,
-0.0034204654,
0.0030404138,
-0.023680404,
-0.009817724,
0.024792096,
-0.011029871,
-0.041306768,
-0.0021246064,
0.0326811,
0.017050426,
0.0067471736,
-0.015456553,
0.0018081756,
-0.004640984,
-0.0058732224,
0.02548858,
-0.008719425,
-0.01857733,
-0.025957365,
-0.009281968,
0.0044199848,
-0.022140106,
-0.016769154
] |
Daily synchronous rhythms of cell division at the tissue or organism level are observed in many species and suggest that the circadian clock and cell cycle oscillators are coupled. For mammals, despite known mechanistic interactions, the effect of such coupling on clock and cell cycle progression, and hence its biological relevance, is not understood. In particular, we do not know how the temporal organization of cell division at the single-cell level produces this daily rhythm at the tissue level. Here we use multispectral imaging of single live cells, computational methods, and mathematical modeling to address this question in proliferating mouse fibroblasts. We show that in unsynchronized cells | [
-0.021783194,
0.0031137697,
0.014157097,
-0.02458031,
-0.010878403,
-0.0037734667,
-0.022126237,
0.007349024,
-0.021202661,
-0.000755353,
0.0143682,
0.011049924,
0.021453345,
-0.00009529529,
-0.011366579,
0.014447364,
0.0357028,
0.0044661486,
0.0025134454,
-0.0024260357,
-0.023498407,
0.014209873,
0.004627774,
-0.023419242,
0.0040670317,
0.015410521,
0.0002490356,
-0.018128473,
-0.0105881365,
-0.016848661,
0.009117012,
-0.016294515,
-0.012943255,
-0.007395203,
0.010508973,
-0.019210376,
0.01748197,
-0.006590373,
-0.0006333091,
-0.017204897,
0.0062473305,
0.0097503215,
-0.013774472,
-0.0017597417,
-0.018234024,
0.020542964,
0.021849163,
-0.018207636,
-0.0062077483,
0.012659585,
0.016584782,
0.012850897,
-0.021954715,
-0.008628836,
-0.010218706,
-0.019566612,
0.01641326,
0.023089394,
-0.009704143,
-0.028525297,
-0.007678873,
-0.0116634425,
-0.014724436,
0.008378152,
-0.016373679,
-0.00037994422,
-0.010792643,
0.013062,
0.005013697,
-0.015054285,
0.029448872,
0.01321373,
-0.0132797,
0.00022099848,
0.011518309,
-0.019342314,
-0.032562643,
-0.003293537,
0.0011107648,
0.005679991,
0.0002494479,
-0.009090624,
-0.010106558,
0.040980376,
-0.0086618215,
0.010931179,
0.009651367,
0.012131827,
0.00463767,
0.020503381,
0.01965897,
0.027971152,
0.014025157,
0.023894224,
-0.0022429696,
0.005762453,
-0.0061879577,
0.03620417,
-0.01053536,
-0.025028903,
0.005722871,
0.025108067,
0.011049924,
-0.010772851,
-0.03757634,
-0.024356011,
0.032114048,
-0.001057989,
0.013945994,
-0.025662212,
-0.025662212,
0.027417006,
-0.005043383,
-0.029264158,
0.0043111197,
0.0038988092,
0.018906916,
0.015318164,
-0.0113204,
-0.01641326,
0.029105831,
0.026955219,
0.022878291,
-0.01935551,
0.029000279,
0.009466652,
-0.0028251524,
0.0031665454,
-0.015951473,
-0.004660759,
-0.014262648,
-0.0040043606,
-0.020133952,
0.027680885,
-0.017046569,
-0.0077844243,
0.0007137097,
0.016426455,
-0.0010126348,
-0.0138272485,
0.0010480935,
0.006768491,
-0.025978867,
0.002251216,
0.011887739,
0.04032068,
0.022258176,
0.009552412,
-0.004195673,
0.0060065407,
0.017006988,
-0.008371554,
0.006606865,
-0.0015618326,
0.027971152,
0.028630849,
0.0034205287,
0.02364354,
-0.0060230335,
-0.018049309,
0.028841952,
-0.0060098395,
0.042827528,
0.0029999719,
0.024896964,
0.019078437,
0.010443003,
0.010456197,
-0.0005054928,
-0.007678873,
-0.0074875606,
0.0070785484,
-0.009565606,
0.04145536,
-0.0048751608,
0.009051043,
-0.012296751,
0.0074611725,
-0.0322196,
-0.018431934,
-0.029580813,
0.0051390394,
0.014143903,
0.0056008273,
-0.029396096,
-0.008114273,
0.0049147424,
0.0031962318,
0.01443417,
-0.0043111197,
-0.0256886,
-0.009974618,
0.00008988371,
-0.011109297,
-0.6404866,
-0.0055414545,
-0.014355006,
-0.027733661,
-0.005000503,
0.017706268,
0.005980153,
0.008266003,
-0.020820037,
-0.000013400095,
-0.0017185106,
0.01486957,
0.013418237,
-0.022522055,
-0.0014628781,
-0.033327892,
0.0056107226,
-0.00790317,
-0.011419355,
0.0143682,
-0.011782188,
0.006821267,
0.009321518,
0.028129479,
0.009855873,
0.005798736,
0.033802874,
0.0029834795,
-0.004103315,
0.042853914,
-0.025226813,
0.015225806,
-0.009671157,
-0.035887513,
0.041956726,
0.0015906943,
0.0007776178,
0.02407894,
0.0049180407,
0.034488957,
-0.014394588,
-0.011432548,
0.013246715,
0.017864594,
-0.03419869,
-0.0122637665,
0.0067256107,
-0.03024051,
0.004413373,
-0.016386872,
0.0020219712,
0.0055348575,
-0.035412535,
0.02592609,
0.004802594,
-0.0019081734,
0.017745849,
-0.0012138424,
0.010132945,
0.009169788,
0.0061648684,
-0.0034700062,
-0.01473763,
0.003836138,
-0.02451434,
0.02897389,
-0.011485324,
-0.005122547,
0.0030379046,
-0.0014892659,
-0.0019279644,
0.018497903,
-0.007995527,
-0.010264885,
-0.010001006,
0.016650751,
0.018616648,
0.0040604346,
-0.0028564879,
0.012230782,
-0.014935539,
-0.007151115,
-0.02072768,
-0.008008721,
0.02686286,
-0.0032753954,
0.00185045,
0.021994296,
-0.0069136242,
0.0066860286,
0.0056832894,
-0.0009169788,
0.0381041,
-0.026717728,
-0.015252194,
0.033512607,
-0.015832728,
-0.0015799742,
0.0006963926,
-0.03060994,
0.0008864678,
-0.009770112,
0.005518365,
-0.0017383015,
0.022997037,
-0.0024375804,
-0.029897466,
-0.014117515,
0.042985853,
-0.021506121,
0.002741041,
0.00079534715,
-0.008364958,
0.0021473137,
0.004426567,
-0.020503381,
0.029712752,
0.019830491,
0.0102253035,
-0.021400569,
-0.006659641,
-0.021849163,
0.023564376,
-0.018458322,
0.027575333,
0.0072566667,
0.00032407613,
-0.008978476,
-0.021730417,
-0.0046145804,
0.0027163022,
-0.009281936,
0.023960194,
-0.02411852,
0.020054787,
0.0011206602,
0.024527533,
0.0010868508,
0.026044836,
-0.034304243,
-0.026625369,
-0.0077910214,
0.0028878234,
-0.0169806,
0.0039218985,
-0.015331358,
-0.04454274,
0.020358248,
0.008694806,
-0.0040043606,
-0.007052161,
-0.0048421756,
-0.003714094,
0.00441997,
0.014117515,
-0.0039845696,
-0.020635322,
-0.020688096,
-0.013642534,
0.0073358305,
0.008971878,
0.0056898864,
-0.02847252,
0.013299491,
-0.0208992,
0.0072302786,
-0.019645777,
-0.0076392908,
0.012197797,
-0.028155867,
-0.0031533516,
-0.010852016,
0.002910913,
0.018392352,
0.01604383,
0.011274221,
-0.018405546,
-0.015423715,
-0.02508168,
-0.021202661,
0.004123106,
-0.003380947,
-0.0117887845,
-0.017033376,
0.028815564,
0.022284564,
0.05385766,
-0.012468273,
-0.002163806,
0.039660983,
0.030768266,
0.027469782,
-0.02461989,
-0.0085364785,
0.010443003,
-0.019764522,
-0.015384133,
0.0007372114,
0.023775479,
0.04108593,
0.024791412,
-0.0278656,
0.0067454013,
-0.022179011,
0.0037107954,
-0.008701403,
0.01314776,
-0.0086750155,
0.013141164,
0.013893218,
0.010871806,
0.0077052605,
0.008325376,
-0.018709006,
0.009413876,
0.0017861295,
-0.020740872,
-0.008892715,
-0.008213228,
0.0046772514,
-0.007441382,
-0.011294012,
0.023775479,
0.00023378011,
0.004040644,
0.017046569,
0.010799239,
0.030583551,
0.005557947,
0.0008914155,
-0.008549673,
0.028657237,
-0.0078240065,
0.023841448,
0.017627103,
0.018458322,
-0.014764018,
-0.01321373,
0.030689104,
0.02897389,
0.002973584,
0.02009437,
0.018181248,
-0.0022132834,
0.0028498909,
-0.0014653519,
0.026572594,
0.0060098395,
-0.007606306,
-0.024725443,
-0.0125012575,
0.008595851,
-0.040373456,
-0.008444121,
0.008444121,
-0.012725554,
0.0052149044,
-0.0061120926,
0.011129088,
0.013510594,
-0.0061615696,
0.021756805,
0.010238497,
-0.026242746,
-0.027153127,
0.016386872,
0.021215854,
-0.019830491,
-0.03435702,
0.0045486107,
-0.010159333,
0.0011610667,
0.017864594,
-0.04541354,
0.040663723,
-0.004509029,
0.018814558,
0.00035314405,
0.020595739,
0.0050928607,
-0.02444837,
-0.0119141275,
-0.0031813886,
0.019527031,
-0.0063957623,
-0.0067124167,
-0.008470509,
0.002096187,
0.004736624,
-0.0072302786,
-0.0069993846,
0.017138926,
-0.014420976,
-0.016663946,
-0.0120262755,
-0.007659082,
0.014420976,
-0.007052161,
0.010297869,
-0.0076392908,
-0.01430223,
0.025767764,
0.010660703,
-0.01835277,
0.03169184,
-0.0077184546,
0.0014620534,
-0.019843685,
-0.004911444,
-0.012283557,
-0.013919606,
-0.008140661,
-0.011498518,
-0.004443059,
-0.00007900902,
0.007876782,
0.0037009,
0.0010324258,
0.033697322,
-0.0065013138,
0.008833342,
0.009064237,
-0.012455079,
-0.022891484,
0.032800134,
0.013042209,
-0.0039812713,
0.0150278965,
-0.0061120926,
-0.018616648,
-0.010997148,
-0.029000279,
0.024158103,
-0.013893218,
-0.01721809,
-0.04306502,
0.0012113686,
0.0037470788,
-0.010594733,
0.020292278,
-0.010139543,
-0.0023353272,
0.000641143,
0.028947502,
0.011096103,
-0.0038394365,
0.028578073,
0.045571867,
0.024197685,
-0.005353441,
0.011834963,
0.026717728,
-0.006369374,
-0.027205903,
-0.0075601274,
0.032430705,
0.006319897,
0.021875551,
0.0059273774,
-0.026321908,
0.011980097,
0.0073160394,
-0.004693744,
-0.003476603,
-0.012323139,
0.031771004,
0.0064584333,
-0.02290468,
0.0103374515,
-0.001602239,
-0.0053732316,
0.0036679152,
-0.013088387,
-0.011208251,
0.03034606,
-0.01560843,
0.006277017,
-0.0235116,
-0.0039087045,
0.012415497,
-0.012237378,
-0.012243976,
0.010720076,
-0.008404539,
-0.0048388774,
-0.018128473,
0.016320903,
-0.003559065,
0.009822888,
0.017759042,
0.0069334153,
-0.018075697,
-0.037127744,
0.0035194834,
-0.009460054,
-0.027971152,
-0.02370951,
-0.00018832287,
0.037259683,
0.0120262755,
0.031269636,
-0.008239615,
-0.004192374,
0.016360484,
-0.010891597,
-0.0028070107,
-0.022086654,
-0.015239,
-0.03148074,
0.0025282886,
0.021901939,
-0.006907027,
-0.0015156538,
0.01008017,
0.015080673,
0.0056634983,
0.034119528,
-0.004185777,
-0.009077431,
0.016901437,
0.017811818,
0.018036116,
0.006511209,
-0.026335103,
0.018761782,
-0.011208251,
-0.011432548,
0.0037668697,
0.0017943757,
-0.02274635,
0.003258903,
0.03359177,
-0.012738748,
-0.0010868508,
0.012204394,
-0.011109297,
0.0082857935,
0.009783306,
0.0055612456,
0.007751439,
-0.0030560463,
0.016386872,
0.006580477,
-0.017956952,
-0.004053838,
0.008635433,
0.016584782,
-0.012204394,
-0.019183988,
0.011505115,
-0.009631576,
-0.024844188,
-0.025332363,
-0.0006671186,
0.010436406,
0.031058533,
-0.0007883379,
-0.06280315,
-0.015661206,
-0.011089506,
0.010489182,
0.011874545,
-0.015713982,
-0.0006609339,
-0.0024986023,
0.008345166,
0.0058449153,
-0.034488957,
0.019566612,
-0.04253726,
0.015450103,
-0.016703527,
0.009875664,
0.0213346,
-0.0037239895,
-0.020424219,
-0.010139543,
-0.010640912,
0.0050730696,
-0.041613683,
-0.016954212,
-0.029132219,
0.05557287,
0.03868463,
0.03121686,
0.012474869,
-0.009855873,
0.019513836,
0.016057024,
-0.016070219,
-0.0042880303,
0.007170906,
-0.012402303,
0.022601219,
-0.0029752334,
-0.004716833,
0.0028960698,
0.011129088,
0.0100142,
0.037972156,
-0.0042913286,
-0.022244982,
-0.014684854,
0.0010381981,
-0.023947,
-0.0041593895,
-0.0026437356,
-0.01225717,
0.00009204834,
-0.040135965,
0.024778219,
0.02923777,
0.0102253035,
-0.038262423,
0.027021188,
-0.012230782,
0.032536253,
-0.02642746,
0.032140438,
-0.039608207,
-0.019078437,
-0.025635824,
-0.0020153741,
0.028182255,
0.0043012244,
-0.0025728182,
0.025662212,
-0.007863588,
-0.006498015,
0.0035491697,
-0.029316934,
-0.00994823,
-0.009690949,
-0.010654106,
-0.028525297,
-0.00992844,
-0.029580813,
-0.0074018,
-0.012930061,
0.026664952,
-0.03707497,
0.011115894,
0.004502432,
-0.011953709,
0.038262423,
-0.0048355786,
0.013853637,
-0.018695813,
0.04108593,
0.008384748,
0.0050796666,
-0.004040644,
-0.034040365,
-0.0035821546,
-0.0054688877,
0.027891988,
0.009090624,
-0.022561636,
-0.013695309,
0.02163806,
0.0038328394,
-0.017006988,
-0.03559725,
0.0014199978,
0.012402303,
-0.011808576,
-0.011135685,
-0.0161098,
-0.011584279,
-0.011307206,
-0.019381898,
0.017429193,
-0.003300134,
-0.007929558,
-0.029448872,
0.024474757,
-0.02320814,
0.005429306,
-0.013814054,
-0.00091203104,
0.0028564879,
-0.004436462,
-0.026519818,
-0.013814054,
0.003796556,
-0.002592609,
-0.0110763125,
-0.0009648068,
0.008978476,
-0.0050235926,
-0.0076195,
-0.015687594,
-0.012131827,
0.04467468,
0.00034056857,
-0.007672276,
0.0066827303,
0.023498407,
0.0054589924,
-0.0070125787,
-0.015199418,
0.018049309,
-0.03770828,
0.006583776,
0.030900206,
0.018273607,
0.016202157,
-0.0021868953,
-0.007975737,
-0.019579805,
-0.036151394,
-0.0051753228,
0.0023039917,
-0.045387153,
-0.0001914152,
0.009004864,
0.032483477,
0.015648013,
-0.009565606,
-0.009189579,
-0.0145529155,
0.029000279,
-0.012620003,
0.03892212,
0.0056964834,
0.00014503025,
-0.032404315,
0.0047498182,
-0.027733661,
-0.03979292,
0.009565606,
-0.025794152,
-0.038658243,
0.0033430143,
0.011518309,
0.0070719514,
-0.025055291,
-0.0025134454,
0.008028512,
0.022231787,
0.013444624,
0.008233018,
-0.013226924,
0.0026635265,
-0.009783306,
-0.0072302786,
0.017389612,
-0.014183485,
0.008430927,
0.0019593,
-0.018920109,
-0.00833857,
-0.0015634819,
-0.0049279365,
-0.011234639,
0.01234293,
-0.0075007547,
-0.0020516575,
-0.017547939,
-0.014117515,
-0.030530775,
0.024857381,
-0.00973053,
-0.008681612,
-0.03111131,
-0.01271236,
0.002368312,
0.030003019,
-0.0053633363,
0.0063792695,
0.010812433,
-0.041033152,
-0.032193214,
-0.026401073,
-0.016624363,
0.04079566,
0.014341812,
-0.0033529098,
-0.011419355,
-0.014618885,
-0.016030636,
-0.03084743,
0.038262423,
0.014183485,
0.014724436,
0.0017300553,
0.0017811818,
0.030187733,
-0.008892715,
0.020002011,
-0.0052544866,
-0.019210376,
0.021664448,
-0.020318666,
0.028710011,
0.0038526303,
-0.010357242,
0.011412757,
0.021110304,
-0.010093364,
-0.0065672835,
0.004733326,
0.000004509647,
0.020872813,
0.0019081734,
0.003829541,
-0.0053963214,
0.014909152,
0.0150278965,
-0.019144407,
-0.014209873,
-0.0011750852,
-0.017904175,
-0.023656733,
0.016294515,
-0.012118633,
-0.008134063,
0.01334567,
-0.024646278,
-0.025437916,
0.034277853,
-0.018867332,
0.018986078,
0.009189579,
0.017152121,
0.008846536,
0.019368703,
-0.020041594,
0.0014422626,
-0.0017399507,
-0.023801867,
-0.0038856152,
0.018458322,
-0.017046569,
0.012672779,
0.0004980712,
0.013226924,
-0.021624867,
-0.0036382289,
-0.017323643,
-0.0024722144,
-0.02562263,
0.01574037,
0.009229161,
0.0008081288,
-0.0060032425,
0.00023068779,
-0.023036618,
-0.0032671492,
-0.0130026275,
0.0070323697,
-0.014223067,
0.021598479,
-0.008384748,
0.003367753,
0.0105881365,
-0.022759546,
0.011392967,
-0.012204394,
0.0048751608,
0.1843985,
-0.019738134,
-0.011399563,
0.014486945,
-0.007969139,
-0.006408956,
0.008101079,
0.0069268183,
-0.010581539,
0.011597472,
0.012158215,
-0.00021378305,
0.0041659866,
-0.00013297018,
0.015357746,
-0.018906916,
-0.0067091184,
0.014764018,
-0.0067190137,
-0.0003131499,
0.023669926,
-0.039238777,
-0.011023536,
-0.0039153015,
0.03459451,
-0.003836138,
-0.017455582,
-0.026533011,
0.002218231,
0.009440264,
-0.017811818,
0.007223682,
-0.011122491,
0.0006427922,
-0.004367194,
-0.00093099737,
-0.0041363,
-0.008892715,
0.018431934,
0.002231425,
0.015410521,
-0.01036384,
-0.0090114605,
-0.011386369,
0.034304243,
0.029633587,
0.015753563,
-0.016822273,
0.014130709,
-0.0057459604,
-0.03694303,
0.00032263304,
0.02052977,
0.035650022,
0.017402805,
-0.009493039,
0.0052907695,
0.02760172,
-0.0014843182,
0.047207914,
-0.031533513,
-0.008938894,
-0.014975121,
0.002251216,
-0.014684854,
0.015436909,
-0.02177,
0.025147649,
0.012019679,
-0.0145661095,
0.000821735,
-0.0048553697,
-0.03010857,
-0.011432548,
-0.0011511712,
0.0045354166,
0.029897466,
0.019012466,
0.0046310727,
0.031322412,
0.0007087619,
-0.008351764,
-0.026084417,
-0.011993291,
0.013510594,
-0.01767988,
0.036652762,
0.016400067,
-0.002980181,
-0.01203947,
-0.0062308377,
-0.013998769,
-0.007916364,
-0.005191815,
0.008008721,
-0.042959467,
0.0072896513,
-0.008668418,
0.002407894,
-0.018577067,
-0.02364354,
0.060586568,
0.023617152,
0.01661117,
-0.0047465195,
-0.0013309387,
0.00076483615,
-0.00185045,
0.0045387154,
-0.02508168,
-0.0052017104,
-0.028340582,
0.0070125787,
-0.017890982,
0.0064386423,
0.040953986,
0.015582043,
-0.042721976,
0.018511096,
-0.01234293,
0.0005982627,
-0.026110806,
-0.002238022,
0.013814054,
-0.0069334153,
-0.018049309,
0.004014256,
0.0046244757,
-0.00038118116,
-0.032272376,
0.0014843182,
0.009519427,
-0.004340806,
-0.006907027,
0.014856376,
-0.01423626,
0.00052198523,
-0.032008495,
-0.021163078,
0.0043803877,
-0.013319282,
0.011544697,
-0.009453458,
0.022390116,
0.006972997,
-0.010786045,
0.021994296,
0.018524291,
-0.03770828,
-0.028314194,
0.005788841,
-0.025873315,
0.011195058,
-0.007428188,
0.010812433,
-0.019118018,
-0.019104823,
-0.037470788,
0.0011470481,
-0.003727288,
-0.004116509,
-0.009849275,
0.017033376,
-0.0037767652,
-0.0014892659,
0.023340078,
-0.16497701,
-0.002640437,
0.03235154,
-0.018405546,
0.010284675,
0.0029076145,
-0.0013004276,
0.01430223,
-0.012494661,
-0.004815788,
0.008213228,
0.01212523,
-0.021057528,
-0.017336836,
0.011129088,
0.0127519425,
-0.020925587,
0.033802874,
0.00055868085,
0.01053536,
0.017970145,
-0.026044836,
0.023485212,
-0.023115782,
0.015410521,
0.0053369487,
0.02113669,
0.0038394365,
0.012092246,
-0.035148654,
-0.0156744,
0.011689831,
-0.007942751,
0.010429809,
0.014935539,
-0.016941018,
-0.014275842,
-0.003313328,
0.0097965,
0.009770112,
0.014724436,
0.03295846,
-0.00792296,
0.014091128,
-0.004489238,
0.040848438,
-0.003687706,
0.00659697,
0.0075007547,
-0.0339612,
0.015661206,
-0.012732152,
-0.015938278,
0.017270867,
-0.006907027,
0.007744842,
0.024026163,
0.0094996365,
0.0058317212,
-0.015054285,
-0.0001120454,
-0.021558898,
0.034251466,
-0.002749287,
-0.018933304,
-0.011234639,
-0.006590373,
0.02344563,
-0.025899703,
0.0013985576,
-0.032193214,
0.013174148,
0.011703025,
-0.031005757,
0.03169184,
-0.00446285,
-0.0050499802,
-0.009961424,
0.012362721,
0.012092246,
-0.01205926,
0.017508358,
-0.012804718,
-0.024778219,
-0.018603455,
-0.015384133,
0.03171823,
0.038209647,
-0.007942751,
0.00093841896,
0.0357028,
-0.008120869,
0.008905909,
-0.01965897,
0.017706268,
0.016782692,
-0.00036757492,
-0.0087871635,
0.014922345,
-0.007969139,
0.006679432,
-0.003367753,
-0.00927534,
0.035781965,
0.031296026,
0.0036217363,
-0.019263152,
-0.029633587,
0.042985853,
-0.015502878,
-0.023999775,
-0.012606809,
0.0011148879,
0.01038363,
-0.0036448257,
0.046917647,
0.024369206,
0.008919103,
0.007362218,
-0.019988818,
0.07821367,
0.020107564,
-0.016083412,
0.023274109,
-0.01667714,
-0.016584782,
-0.13953911,
-0.006039526,
-0.0027228992,
0.03111131,
-0.0075601274,
0.020081175,
-0.007817409,
0.027311454,
0.009677755,
0.038236037,
-0.009281936,
-0.011551294,
-0.017376417,
-0.0045387154,
0.010403421,
-0.009097221,
-0.0033479622,
-0.01822083,
-0.022719964,
0.0132797,
0.009994409,
0.001656664,
-0.0024969531,
-0.009242355,
0.014711242,
0.012771733,
-0.02605803,
0.019645777,
0.019131212,
0.008444121,
-0.005346844,
-0.013866831,
-0.017455582,
-0.010924581,
0.0011866299,
0.003559065,
-0.013748085,
-0.03596668,
0.021585286,
-0.02886834,
-0.010957567,
0.027707273,
0.02629552,
0.022693576,
0.012930061,
-0.0021341196,
-0.0018108682,
0.01919718,
0.0045057302,
-0.0045288196,
-0.012798121,
-0.003407335,
-0.024171297,
-0.024830993,
0.0269948,
-0.01885414,
0.0054721865,
0.009123609,
-0.0130026275,
-0.014843182,
0.014605691,
-0.0021275228,
-0.00899167,
0.015239,
0.015370939,
-0.03285291,
-0.031665456,
-0.0054523954,
0.029950242,
-0.004367194,
-0.002135769,
0.012580421,
-0.0143286185,
0.0018306591,
-0.01584592,
0.002932353,
0.0036349304,
0.00013224862,
-0.012877285,
0.011597472,
-0.0058383183,
-0.02344563,
0.014500139,
0.0014043299,
0.0040835245,
-0.00929513,
-0.007593112,
0.0093611,
-0.0008633784,
0.012534242,
-0.02227137,
0.030530775,
-0.005647006,
-0.011887739,
-0.005026891,
-0.0034733044,
-0.0022809024,
0.0088993125,
0.021664448,
0.020648515,
-0.026678145,
-0.0222054,
-0.026902443,
0.020595739,
0.003611841,
-0.002483759,
0.018154861,
0.005679991,
0.011063118,
0.0054062167,
0.023102587,
0.012685972,
-0.008760775,
0.009651367,
-0.0052346955,
-0.02052977,
-0.029079443,
-0.019183988,
0.025873315,
0.0006192905,
0.018880527,
0.018774975,
-0.001445561,
-0.0051324423,
0.014223067,
0.023234528,
-0.0070125787,
-0.0040109577,
-0.0023930508,
0.008655224,
-0.013451221,
0.001319394,
0.0096249785,
-0.028947502,
-0.013378655,
0.008879521,
-0.011043327,
-0.028657237,
0.0081868395,
0.036256947,
0.017930564,
0.046310727,
-0.019210376,
-0.027126739,
0.003019763,
-0.0022528651,
0.014064739,
-0.00044570776,
-0.036388885,
0.012145021,
0.00021378305,
-0.005581036,
0.022126237,
0.010786045,
0.0064056576,
-0.006801476,
-0.007843797,
-0.010245094,
-0.010931179,
-0.007170906,
-0.0061945547,
-0.032694582,
0.013550175,
0.02923777,
0.0025084978,
-0.021413764,
-0.0062506287,
0.005808632,
-0.034013975,
-0.014645273,
-0.023735898,
-0.012356124,
-0.034304243,
0.008364958,
0.023181751,
-0.006263823,
-0.013081791,
-0.0056437077,
-0.032694582,
0.014895958,
-0.0028317492,
0.014460557,
0.016650751,
-0.0017432492,
-0.014183485,
0.0070191757,
0.02984469,
-0.0017531447,
0.0020054788,
0.04153452,
0.00994823,
0.007612903,
-0.0064320453,
0.0057525574,
0.02016034,
0.004476044,
0.010403421,
0.011703025,
-0.03422508,
-0.0034799015,
-0.014790406,
0.033380665,
0.00929513,
0.012600212,
0.014196679,
-0.032536253,
-0.014526527,
0.033538993,
-0.029290546,
-0.03670554,
-0.025253199,
0.013490803,
-0.010489182,
0.00690043,
0.018946497,
-0.0047531165,
-0.018603455,
0.02146654,
0.0043869847,
-0.004169285,
-0.005531559,
0.008266003,
0.0031451052,
-0.017745849,
0.007573321,
0.002170403,
0.002299044,
0.00059537654,
0.016360484,
-0.025649019,
0.0417984,
-0.018062502,
0.047682896,
0.0012880584,
-0.0104496,
-0.014961927,
-0.018959692,
-0.033327892,
0.004509029,
0.014856376,
-0.022891484,
0.072619446,
-0.009921842,
-0.011637054,
0.02157209,
-0.034488957,
0.012375915,
0.0041132104,
0.02625594,
-0.032536253,
-0.033855647,
0.0226408,
-0.0074743666,
0.019606194,
-0.040426232,
-0.010693688,
0.03520143,
0.0032440599,
0.01965897,
0.009070833,
-0.021690836,
0.021558898,
-0.037233297,
-0.0024095431,
0.007382009,
-0.015872309,
-0.027126739,
0.02562263,
0.0077910214,
-0.009875664,
-0.020450607,
0.016505618,
-0.03121686,
-0.01909163,
0.001391136,
-0.010627718,
0.0066233575,
-0.0062407334,
-0.019118018,
0.018774975,
0.020173533,
-0.053910438,
-0.007210488,
-0.018629842,
0.0103374515,
-0.035623636,
-0.0020467099,
-0.006986191,
-0.0010431458,
-0.03158629
] |
Background. Artemisinin-based combination therapy (ACT) reduces microscopically confirmed gametocytemia and mosquito infection. However, molecular techniques have recently revealed high prevalences of submicroscopic gametocytemia. Our objective here was to determine the effect of sulfadoxine-pyrimethamine (SP) monotherapy and treatment with SP plus amodiaquine (AQ), SP plus artesunate (AS), and artemether-lumefantrine (AL; Coartem) on submicroscopic gametocytemia and infectiousness. Methods. Kenyan children (n=528) | [
-0.005765061,
0.012997592,
0.011692422,
-0.01944905,
-0.022640966,
0.029998604,
-0.0044801794,
-0.008919783,
-0.023087293,
-0.02035523,
0.005994987,
0.007371163,
0.012943491,
0.006965411,
0.011760048,
0.015864907,
0.036517687,
0.00035059516,
0.009197047,
-0.010522504,
-0.02035523,
0.023195494,
-0.00034277598,
-0.013842909,
-0.0010135348,
0.009095609,
0.009136184,
-0.036679987,
-0.021072058,
0.0000053921967,
-0.0015486204,
0.0005160659,
-0.0054810345,
-0.0009476002,
-0.025819357,
-0.009454024,
0.015810806,
0.012307813,
0.014796426,
-0.0012798097,
0.007384688,
0.007621377,
0.00032734894,
0.015405054,
-0.013734709,
-0.014580025,
0.0036889627,
0.02016588,
-0.027861644,
0.021139683,
0.0019323943,
0.0037836381,
-0.01923265,
-0.0047439183,
-0.008101516,
-0.0023499809,
-0.018177694,
0.0084869815,
0.03143226,
-0.032433115,
-0.016798137,
-0.0025646912,
-0.043685973,
0.018137118,
-0.012463352,
0.020206453,
0.0009366111,
0.0065562776,
-0.0023499809,
0.008074466,
0.04282037,
0.025278354,
0.014552975,
-0.023209019,
0.0294035,
-0.022546291,
-0.046120487,
0.014688225,
0.0085072685,
0.003908745,
0.018042443,
0.011590985,
0.0016720367,
0.0014345027,
0.017893666,
0.010657755,
0.007695765,
0.025143104,
0.022086438,
0.0025342598,
-0.004273922,
0.019070348,
0.033596274,
0.021220835,
-0.014133697,
0.013768521,
-0.0010684805,
0.04863615,
-0.024534477,
0.0041488153,
-0.008696619,
0.00037299606,
-0.007411738,
-0.016189508,
-0.01843467,
0.0028994367,
0.0028588616,
0.008595182,
0.012314576,
-0.007898641,
-0.017041588,
0.039682552,
0.02051753,
-0.039790753,
-0.0034252238,
0.0038478824,
0.000112215814,
-0.020017102,
-0.0074049756,
0.0073779253,
0.005173339,
0.021599537,
0.027807543,
0.004175865,
0.023033194,
0.00677606,
-0.041224413,
-0.011530122,
-0.025061954,
-0.027807543,
-0.01112437,
0.033731524,
0.024913179,
-0.0011487856,
-0.0016872524,
0.0023719592,
-0.03475943,
0.0003292509,
-0.030458456,
-0.025129579,
0.004500467,
0.04233347,
-0.006701672,
-0.0016475226,
-0.0026830356,
0.010955307,
0.01736619,
0.0007472601,
-0.012429539,
0.009541936,
0.010576604,
-0.023858223,
0.007161524,
0.0007354257,
0.013295143,
-0.0075334636,
-0.0009568987,
0.024683252,
-0.03259542,
0.0036010498,
-0.014674701,
0.00314796,
0.018150643,
-0.011726235,
0.0064548394,
0.019543726,
-0.004970463,
0.008142092,
-0.008534319,
-0.026238635,
-0.0022028957,
0.008743958,
-0.021139683,
0.0067253406,
-0.015337429,
0.0061302376,
0.015229228,
0.011185233,
-0.0052646333,
-0.032027364,
-0.018502295,
0.0057515358,
0.01977365,
-0.005694054,
-0.011381346,
-0.01261889,
-0.010765956,
-0.005169958,
0.018069493,
0.004781112,
0.004916363,
0.016040733,
-0.017487915,
-0.022776216,
-0.6505017,
-0.024345126,
-0.004246872,
-0.019570775,
0.03099946,
-0.0030989316,
0.032135565,
0.0040541394,
-0.03124291,
0.019800702,
-0.0011724544,
0.044551577,
0.000872367,
-0.015864907,
0.008020367,
-0.021247884,
-0.0057346295,
-0.0145394495,
0.024142249,
-0.011962924,
-0.008967121,
0.006022037,
-0.0028622427,
0.0056196665,
0.010441354,
-0.0004194885,
0.013748233,
-0.009541936,
-0.012652703,
0.011171707,
-0.016054258,
0.041711316,
0.009386398,
0.027780492,
0.05009686,
-0.023154918,
-0.010394016,
0.009190285,
0.005112476,
0.048960753,
-0.021329034,
-0.009724525,
0.024061099,
-0.026982514,
0.00089096394,
0.018529344,
-0.002870696,
-0.0074658385,
-0.008128567,
-0.0008055869,
0.012104937,
-0.012909679,
-0.013788808,
0.0050042756,
0.006238438,
0.032270815,
-0.008588419,
-0.018556396,
-0.0071277115,
0.0100153135,
-0.023465995,
-0.00821648,
0.009014458,
-0.014891102,
-0.016973963,
0.023195494,
0.005890168,
-0.0038850761,
0.014444774,
-0.011929112,
0.016662886,
0.03367742,
-0.03724804,
0.014525925,
-0.0020659543,
0.015472679,
0.006637428,
-0.016148932,
-0.01744734,
-0.0017134573,
0.0023415277,
0.012010261,
-0.002395628,
-0.001059182,
0.03567913,
-0.015161603,
-0.028619047,
0.0043922663,
0.017704315,
0.0070127486,
-0.0026018852,
0.02131551,
0.0054776534,
-0.0195843,
0.0073035373,
0.029863354,
-0.013558882,
-0.0019019629,
0.02537303,
-0.046309836,
-0.017677266,
-0.014106647,
-0.0011208901,
-0.020693356,
0.001128498,
-0.005119239,
-0.031919163,
-0.01355212,
0.043090872,
-0.025359506,
-0.009528412,
-0.011097319,
-0.015229228,
-0.025129579,
0.031648662,
-0.028050995,
0.00722915,
-0.0008009377,
0.012686515,
-0.033920873,
-0.00070414896,
0.0075267013,
0.008689857,
-0.0012569862,
-0.01270004,
-0.00049366505,
-0.0014099885,
0.0040676645,
0.0046729115,
-0.030945359,
0.017014537,
0.0066712406,
0.020152353,
-0.008994171,
0.032811817,
-0.02910595,
0.026901362,
-0.0010380491,
0.0144583,
-0.025792308,
-0.012902916,
-0.014755851,
-0.006820016,
0.018840421,
0.01851582,
-0.02345247,
-0.010224952,
0.001961135,
-0.008940071,
-0.0007607852,
-0.0068504475,
0.0060829,
-0.0113745835,
0.023641821,
0.008121804,
-0.011482784,
-0.028591996,
-0.029836303,
-0.006133619,
-0.006752391,
0.025562381,
0.007871591,
-0.011563934,
0.0007430335,
-0.024101675,
-0.01360622,
-0.011171707,
0.005653479,
-0.011090557,
-0.019733077,
0.030458456,
-0.043740075,
-0.016865762,
0.03297412,
0.005440459,
0.022316365,
-0.0083382055,
0.016216557,
-0.008223242,
0.0011048291,
-0.009169997,
-0.0029974936,
-0.01728504,
0.006093044,
0.018948622,
0.0071344743,
0.011908824,
0.00018163746,
0.025657058,
0.032649517,
-0.021653635,
0.007925691,
-0.0101640895,
0.010400779,
0.0050651385,
-0.006769297,
0.011029694,
0.021383135,
0.0022654491,
0.047608245,
0.033488072,
0.0036855815,
0.022275789,
-0.021220835,
0.018718697,
-0.047337744,
-0.0024666346,
-0.008601944,
0.03662589,
0.015364479,
0.010096464,
0.0035232806,
-0.0009467549,
-0.0098192,
0.010989119,
0.0035503306,
0.0013178489,
-0.014580025,
-0.0002705014,
0.004449748,
-0.008175905,
-0.00080474163,
0.007046561,
-0.0040034205,
-0.0140525475,
0.0095689865,
0.01163156,
0.017677266,
-0.00095436274,
-0.0035503306,
-0.017731367,
-0.0039493204,
0.010427829,
0.017988343,
0.02246514,
0.0046052863,
0.008879208,
-0.012483639,
0.028646097,
0.005322115,
-0.012916441,
-0.0043550725,
0.015946057,
-0.011584222,
0.017974818,
0.0034691803,
0.043361373,
0.013518307,
0.014809951,
0.039844856,
0.00325447,
-0.009920638,
-0.022289315,
-0.00019431721,
-0.0065562776,
-0.0030245436,
-0.014999302,
0.018840421,
0.022343414,
0.04474093,
0.014214848,
-0.011110845,
-0.00067878945,
-0.017623166,
-0.00584283,
0.0044193165,
0.023777071,
-0.023979949,
0.013640032,
0.01563498,
-0.027807543,
0.0035266618,
0.003983133,
-0.010813293,
0.003969608,
0.0051429076,
-0.016595261,
0.0072156247,
0.005447222,
-0.012131987,
-0.026238635,
-0.028267395,
0.008547844,
0.0011268073,
-0.014755851,
-0.0071277115,
-0.018935097,
0.01777194,
-0.009129422,
0.0011809076,
0.02049048,
-0.0013736399,
0.021301985,
0.0021048388,
-0.020788033,
-0.03484058,
0.02403405,
0.014688225,
0.0036855815,
-0.003009328,
-0.007296775,
-0.005464128,
-0.032406066,
-0.0059408867,
0.023871748,
0.0012738925,
0.000341508,
-0.022965567,
-0.018083017,
-0.012429539,
0.024710301,
-0.023006143,
-0.0060862815,
0.029295301,
0.007986554,
0.014404199,
-0.037220992,
-0.0032037508,
-0.0058123986,
-0.023209019,
-0.025345981,
-0.026292736,
0.004916363,
-0.0048250686,
0.0390604,
0.024263974,
-0.0063331136,
0.01835352,
-0.0021538674,
0.023682397,
0.0023888655,
-0.016933387,
0.027888693,
-0.01470175,
-0.01854287,
-0.008514031,
-0.00914971,
-0.0085072685,
-0.011476021,
0.019800702,
-0.011496309,
-0.0051395264,
-0.007979791,
0.011996737,
0.0081894295,
-0.004125146,
0.022289315,
0.028132144,
0.016798137,
-0.009947688,
0.0070127486,
0.0056196665,
0.0050888075,
0.000804319,
0.0027641861,
-0.011300196,
-0.0014395746,
0.020693356,
-0.006765916,
-0.008493744,
0.011219045,
0.00016980302,
0.0026982513,
-0.0070533236,
0.041927714,
0.021261409,
0.005690673,
0.0013482803,
0.0019053442,
-0.021856513,
-0.012815003,
-0.004757443,
-0.013673846,
-0.0243316,
0.023790598,
0.0022164208,
-0.011875011,
-0.012470114,
0.028781349,
0.0029433933,
-0.03270362,
0.0030769533,
-0.01077948,
-0.020422855,
-0.010921493,
-0.021991763,
0.017068638,
-0.011847961,
-0.02540008,
-0.015540305,
-0.010745668,
-0.006573184,
-0.026008708,
-0.0048994566,
-0.0030110185,
-0.028456746,
-0.017244464,
0.002016926,
0.009027984,
0.005322115,
0.028754298,
-0.014174273,
-0.014512399,
0.029917454,
-0.021599537,
-0.013640032,
0.003092169,
-0.03530043,
0.0294576,
-0.005568947,
0.016865762,
-0.0031141473,
-0.028429696,
0.026955463,
-0.002316168,
-0.004043996,
0.01168566,
-0.028294446,
-0.014444774,
0.006623903,
-0.007871591,
0.0242234,
-0.022451615,
-0.0067253406,
0.005038088,
-0.047797594,
0.0037464444,
-0.028213294,
-0.011198757,
-0.0018292656,
-0.018975673,
0.010921493,
-0.041467864,
-0.025359506,
-0.0055959974,
-0.02024703,
0.0098192,
-0.0020034008,
0.03730214,
0.00068893324,
-0.0055959974,
0.0072561996,
0.00512262,
-0.00269487,
-0.014404199,
0.008771008,
0.00877777,
0.024412751,
-0.026779637,
0.007080374,
0.025089003,
-0.008906258,
-0.039844856,
-0.0031496505,
-0.0015934223,
0.041576065,
0.009122659,
-0.019908903,
-0.017393239,
-0.023073768,
-0.017663741,
0.00065512053,
0.003743063,
0.0009425283,
0.020057678,
0.00517672,
-0.014661175,
-0.0054032654,
0.01654116,
-0.02550828,
0.009264672,
0.0057346295,
-0.023695922,
-0.0003451006,
-0.01115142,
-0.014809951,
-0.01862402,
-0.0017531872,
-0.03713984,
-0.030269105,
0.007296775,
-0.013119318,
0.017934242,
0.011435446,
0.0388981,
0.0039290325,
0.007837778,
0.0014809951,
0.007689002,
0.006623903,
0.0061775753,
0.023668872,
-0.008980646,
0.011070269,
0.009893589,
-0.00581578,
-0.02070688,
-0.021207308,
0.030187955,
0.03489468,
-0.031026509,
-0.019070348,
0.022830317,
-0.011841198,
-0.01024524,
0.005220677,
0.010657755,
0.009528412,
-0.037599694,
-0.005880024,
0.041657213,
0.005741392,
0.00035714637,
-0.0055283722,
0.021951187,
-0.00023795669,
0.017082162,
-0.011340771,
0.021329034,
-0.024548002,
0.004980607,
0.0017700935,
-0.002382103,
-0.0050178007,
-0.005944268,
0.0027219201,
0.005301827,
-0.0051260013,
-0.00861547,
0.028727248,
0.004564711,
-0.006106569,
0.0005773514,
-0.038032494,
-0.018015392,
-0.0027675673,
-0.0104616415,
-0.03497583,
-0.009426974,
0.02329017,
-0.0046593864,
0.005694054,
0.0028825304,
-0.0097651,
0.0017498059,
-0.014850526,
0.029890403,
-0.009359349,
0.012605364,
0.015986633,
0.001109901,
0.012240188,
-0.005677148,
-0.013288381,
-0.01352507,
0.024453325,
0.016933387,
-0.015066927,
-0.014201323,
0.019340849,
0.018610496,
-0.002691489,
-0.03135111,
0.012848816,
0.016419435,
-0.0015122718,
-0.022343414,
-0.008987409,
-0.027334165,
0.038032494,
0.00033580212,
-0.008601944,
0.022397514,
0.0056805294,
-0.02150486,
0.0031226005,
-0.0019729696,
0.009142947,
-0.0004606977,
-0.013328956,
0.010448116,
-0.02504843,
-0.011516597,
-0.00157398,
-0.005251108,
0.0389522,
-0.016121883,
-0.008054179,
0.0011656919,
0.0035638558,
-0.0064176456,
-0.004568092,
-0.0077701523,
0.038059544,
-0.01723094,
0.0048081623,
0.01835352,
0.0107591925,
0.0076078516,
0.009088847,
0.00605585,
-0.004196153,
-0.024588576,
-0.007837778,
0.03116176,
0.015405054,
-0.011962924,
0.0033339297,
-0.021761836,
-0.005322115,
0.013863197,
-0.025535332,
0.017312089,
-0.049853407,
0.013207231,
0.00033749276,
-0.0074928887,
0.021126159,
0.0014505637,
-0.008202954,
-0.012429539,
0.009602799,
-0.02249219,
-0.005964556,
0.022708591,
0.0033846486,
-0.018962147,
0.006525846,
-0.008568131,
-0.028483797,
0.006045706,
-0.012936729,
-0.02723949,
-0.026022233,
-0.010130277,
-0.009481073,
-0.01648706,
-0.027969845,
0.016906338,
-0.0041488153,
0.03181096,
-0.020314654,
0.0004666149,
0.021748312,
-0.008344968,
-0.0014970561,
0.027834592,
-0.02710424,
0.0047878744,
0.0007235912,
0.012361914,
0.0077701523,
-0.028429696,
0.009981501,
-0.00637707,
0.006958648,
-0.03502993,
0.004666149,
0.012429539,
-0.019462574,
-0.012490402,
-0.0040676645,
-0.004703343,
-0.0031783914,
-0.0027202296,
-0.025197204,
-0.03099946,
-0.006272251,
-0.016554685,
0.044281077,
-0.010556317,
-0.0012257094,
-0.047256593,
0.004158959,
-0.00795274,
0.014945202,
-0.015946057,
-0.0058495924,
-0.023547146,
-0.0065698023,
-0.027550567,
-0.015445629,
-0.018880997,
0.00256131,
0.007702527,
0.021058533,
0.019043298,
0.017095689,
0.014850526,
0.004057521,
-0.015323903,
-0.00877777,
0.0027658767,
-0.008250292,
0.030512556,
-0.013849671,
-0.05117886,
-0.002819977,
0.028321495,
-0.014336574,
-0.002256996,
0.021342559,
-0.00093238446,
0.0033761954,
-0.015567355,
0.013011117,
-0.025914034,
-0.028375596,
-0.010238478,
-0.017325614,
-0.004919744,
-0.0034353677,
0.019963002,
-0.0037734944,
-0.0028368833,
0.012050837,
-0.015486205,
0.01977365,
-0.024318075,
-0.0061133313,
0.007242675,
-0.025914034,
0.025467705,
0.02425045,
0.019611351,
0.0005701662,
0.017122738,
0.01555383,
-0.009122659,
0.024696777,
0.0075402264,
-0.01549973,
0.009873301,
0.01862402,
0.0016416053,
-0.015242754,
-0.002948465,
0.019624876,
0.0024260595,
0.019381424,
-0.01539153,
-0.005284921,
0.027428841,
0.021924138,
0.0041048587,
-0.0025308786,
0.008879208,
0.016500585,
-0.0032088228,
-0.00581578,
0.011442209,
0.0027523516,
0.013984922,
0.008635757,
-0.009616325,
0.012781191,
-0.013802334,
0.022289315,
-0.012497164,
0.018664597,
0.1937872,
0.009535174,
-0.0010735524,
0.010928256,
-0.019273223,
0.00024493056,
0.026563236,
0.0022671397,
-0.013646795,
0.0134574445,
0.016270658,
0.0071885744,
-0.002985659,
-0.00066357374,
0.003286592,
0.00242775,
-0.010035601,
0.0053457837,
-0.009501361,
-0.02598166,
0.004568092,
0.0052409642,
-0.002094695,
-0.006833541,
0.0017751653,
-0.0026052664,
-0.010265527,
-0.00010724957,
0.0037396818,
-0.0014632435,
-0.00055875443,
0.022235215,
0.003027925,
-0.0044057914,
0.0040811896,
-0.020679832,
-0.0037734944,
0.0000037543955,
0.008202954,
0.013491257,
-0.013349243,
0.021180259,
-0.019990053,
-0.013754996,
-0.022762692,
0.0035198994,
-0.016067782,
-0.021788888,
-0.017623166,
-0.000023074508,
-0.04284742,
-0.0075267013,
0.00013123544,
-0.0004065974,
-0.01840762,
-0.0009027984,
0.029619902,
0.0049535567,
-0.014525925,
0.053369924,
0.0036517687,
0.015973108,
-0.003345764,
0.053802725,
-0.01648706,
0.04406468,
-0.022681542,
-0.01168566,
0.01035344,
-0.010718618,
0.0014683154,
-0.03297412,
0.0016154005,
-0.0045444234,
-0.011239333,
-0.0019019629,
0.027090713,
0.022762692,
0.019029772,
-0.0014666247,
0.0020710262,
-0.0021995145,
-0.004439604,
0.02046343,
-0.016771086,
-0.0147288,
0.011956162,
0.0078107277,
-0.008879208,
0.008453169,
-0.0017514965,
0.0014260495,
-0.008980646,
-0.016689936,
0.015675556,
-0.008568131,
0.012787953,
-0.015729656,
0.007154762,
-0.019908903,
-0.018935097,
0.07184517,
-0.014755851,
0.022911469,
0.02038228,
0.015567355,
-0.010414303,
0.011435446,
-0.003969608,
0.0014632435,
0.035597984,
-0.028429696,
-0.009670424,
-0.023614772,
0.0010363584,
0.014972252,
0.026509136,
-0.018015392,
0.030945359,
-0.010265527,
0.0018411,
-0.02633331,
-0.027631717,
0.023655346,
-0.01944905,
-0.021207308,
-0.024804978,
-0.01648706,
-0.02540008,
-0.034921728,
0.009880063,
-0.007181812,
-0.0067321034,
-0.009616325,
-0.010434591,
0.0013558882,
-0.0054742717,
-0.008121804,
0.0031733194,
0.0056568603,
0.025521806,
0.0046965806,
0.005284921,
0.008696619,
0.0049400316,
-0.027888693,
0.0063297325,
0.009366111,
-0.004578236,
-0.012240188,
-0.014823476,
-0.014580025,
0.0051496704,
-0.0064311707,
0.020030627,
-0.026549712,
0.006224913,
-0.013038167,
0.01651411,
0.021166734,
-0.013565645,
0.016121883,
0.020328179,
-0.0012248642,
-0.0022958806,
0.016581735,
-0.17236349,
0.0011851342,
0.013092267,
-0.019340849,
0.019219125,
0.021572486,
0.009663662,
-0.004838594,
-0.026996039,
-0.018556396,
0.027388265,
0.02131551,
-0.023087293,
0.008385543,
0.030458456,
-0.011881773,
-0.030106805,
0.02638741,
0.037789043,
0.023952898,
0.022681542,
0.0044734166,
0.0027253015,
-0.019935952,
0.034380727,
0.022668017,
-0.007574039,
-0.0031699382,
-0.011996737,
-0.009237623,
-0.032081466,
0.0069315983,
0.024832027,
-0.007831016,
-0.010718618,
0.008581657,
-0.005220677,
0.024548002,
-0.0060389433,
0.019016247,
0.0058022547,
0.0062925387,
0.0064176456,
-0.0019493006,
-0.016081307,
0.04049406,
-0.005643335,
-0.021788888,
0.016676411,
-0.009859776,
0.016257133,
0.000410824,
0.009460786,
0.007932453,
0.020612206,
-0.011300196,
0.0013254568,
-0.000038858157,
0.018069493,
0.002385484,
0.010035601,
-0.012875866,
0.015242754,
-0.006258726,
0.011604509,
-0.009521649,
-0.017947767,
0.006488652,
-0.012104937,
0.027117765,
-0.018529344,
0.0123957265,
0.0021014577,
-0.017109213,
0.011002644,
-0.0026356978,
-0.009007696,
0.034029074,
0.007425263,
0.002985659,
-0.025859933,
0.018908048,
-0.0139037715,
0.00605585,
0.01560793,
0.003844501,
0.00016959169,
0.0077431025,
-0.02051753,
0.009778625,
0.008426119,
-0.03475943,
0.02040933,
-0.0038512636,
0.024318075,
0.002745589,
-0.008135329,
0.016811661,
0.007425263,
-0.0046627675,
0.019543726,
-0.019827751,
-0.016879287,
-0.007154762,
0.023046719,
-0.012693278,
0.008047417,
-0.008771008,
0.032406066,
0.0021792268,
-0.009440498,
-0.008689857,
-0.0046188114,
0.008547844,
0.0075672762,
0.027564092,
0.012253713,
-0.021937663,
-0.033650372,
-0.007235912,
0.069302455,
-0.000006788951,
0.010549555,
0.030187955,
-0.022018813,
-0.0034962306,
-0.13178828,
0.010678043,
-0.00028761907,
0.009278198,
-0.0063432576,
0.017028062,
-0.0023702683,
0.014512399,
0.020531055,
0.011732997,
-0.021694211,
-0.039195653,
-0.023330744,
-0.026928414,
0.023276644,
0.010488692,
-0.001998329,
-0.019246174,
0.006694909,
0.030160906,
-0.010772718,
-0.01101617,
0.006836923,
-0.01357917,
-0.006045706,
-0.0053390213,
-0.0026238635,
0.04092686,
-0.0010000098,
0.040521108,
0.019083872,
-0.013754996,
0.005707579,
-0.020815082,
-0.015229228,
-0.034380727,
-0.013714421,
-0.021193784,
0.012064362,
-0.012152275,
-0.012023787,
0.017731367,
0.009433736,
0.005085426,
0.041981816,
0.0023364557,
-0.0124160135,
0.0031073848,
0.022005288,
-0.029728103,
-0.021545436,
-0.012267238,
-0.010333153,
-0.006492033,
0.0044565103,
0.005031326,
-0.00536269,
0.030106805,
-0.021274934,
0.004919744,
-0.0039493204,
0.0001591309,
0.00885892,
0.0051361453,
0.027009564,
-0.018258844,
-0.026712012,
-0.026495611,
0.015621455,
-0.036409486,
-0.010833581,
0.0077701523,
-0.0144583,
-0.0136265075,
-0.023533622,
-0.0024683252,
-0.00075782655,
-0.026860788,
0.008047417,
-0.010522504,
-0.014742326,
-0.0005765061,
0.0034049363,
-0.014241898,
0.020855658,
0.020111779,
0.018948622,
0.0037024878,
-0.012497164,
-0.0025342598,
-0.018042443,
0.006945123,
-0.004057521,
-0.031838015,
-0.016581735,
0.018908048,
-0.008798058,
-0.027550567,
0.019935952,
0.019151498,
-0.024588576,
-0.04636394,
-0.0583742,
-0.0014750779,
0.01848877,
-0.005930743,
-0.0058360677,
0.00007961828,
0.030864209,
0.01315313,
-0.007445551,
0.0011614653,
-0.041359663,
-0.006698291,
-0.026684962,
-0.0030583562,
-0.034299575,
-0.0013761758,
0.009325535,
0.0070127486,
0.025616482,
0.0120576,
-0.0241152,
-0.00036264092,
-0.003156413,
0.026089858,
0.006167432,
0.016744036,
0.0043347846,
0.007033036,
-0.021870038,
0.007675477,
0.01299083,
-0.026495611,
-0.015486205,
0.006664478,
-0.006184338,
-0.01117847,
0.0075199385,
0.026914889,
0.023209019,
0.024412751,
-0.011158182,
0.001827575,
0.0037836381,
-0.02150486,
0.0009839488,
0.0076822396,
-0.022586865,
0.020003578,
0.009298486,
-0.012740616,
0.033839725,
0.005694054,
0.0025815975,
-0.030728959,
-0.028510846,
-0.010055889,
-0.01750144,
-0.005775205,
-0.015594405,
-0.0074523133,
-0.0035300432,
0.024629151,
-0.013396582,
-0.0071141864,
-0.0033339297,
-0.017758416,
-0.0134574445,
-0.003719394,
0.014174273,
-0.025007853,
-0.0056568603,
-0.019124448,
-0.01024524,
0.012422777,
-0.022668017,
0.0004382968,
0.014999302,
0.006958648,
-0.004757443,
0.0007459921,
-0.01643296,
-0.008960359,
-0.026793163,
0.011022932,
-0.0098462505,
-0.013984922,
0.002825049,
0.032297865,
-0.027631717,
0.017988343,
-0.010874156,
0.0021352703,
0.0023888655,
0.025061954,
0.0025782164,
0.030160906,
0.020111779,
-0.00832468,
0.013971397,
0.019165024,
0.0024209875,
0.0077701523,
0.027415317,
-0.015012827,
0.000034208915,
0.0018258843,
-0.031783912,
-0.023209019,
0.018272368,
0.004361835,
0.016094834,
0.0013897009,
0.015756706,
-0.009751575,
0.006437933,
0.024804978,
0.00060862815,
0.009034746,
-0.03686934,
0.007925691,
0.01846172,
0.026400935,
0.019097399,
-0.01829942,
0.04273922,
-0.013498019,
0.033866774,
-0.03108061,
0.043767124,
-0.003452274,
0.017055113,
0.013071979,
-0.036030784,
-0.00968395,
-0.0038986013,
-0.025914034,
0.028429696,
-0.0020439762,
-0.0053795963,
0.0786077,
0.034488928,
-0.021112634,
-0.0021454142,
0.0046729115,
-0.003295045,
0.0068098726,
0.008980646,
-0.0037701132,
-0.021883562,
0.017028062,
-0.0054100277,
0.02230284,
-0.027428841,
-0.044145826,
0.00016906337,
-0.014228373,
-0.0002988195,
-0.021653635,
-0.0009873301,
0.026022233,
0.0053525465,
0.016148932,
0.03154046,
-0.014350099,
-0.016081307,
0.026143959,
-0.0024446563,
0.00080389634,
-0.028889548,
-0.012348388,
0.009413448,
-0.026739063,
-0.042225268,
0.0042671594,
-0.0017785466,
-0.0049096,
-0.024899652,
0.016865762,
0.00049239706,
-0.012213138,
0.013518307,
-0.029619902,
-0.0067253406,
-0.0062418194,
-0.0033542172,
-0.03681524,
-0.0028622427,
-0.023073768
] |
During continuous speech, lip movements provide visual temporal signals that facilitate speech processing. Here, using MEG we directly investigated how these visual signals interact with rhythmic brain activity in participants listening to and seeing the speaker. First, we investigated coherence between oscillatory brain activity and speaker's lip movements and demonstrated significant entrainment in visual cortex. We then used partial coherence to remove contributions of the coherent auditory speech signal from the lip-brain coherence. Comparing this synchronization between different attention conditions revealed that attending visual speech enhances the coherence between activity in visual cortex and the speaker's lips. Further, we identified a significant partial coherence between left motor cortex and lip | [
-0.04766071,
0.004337514,
0.0373234,
-0.02180445,
0.0017629267,
0.016739687,
-0.0026622466,
0.009713953,
-0.010421721,
-0.028622398,
0.012122962,
0.033868972,
0.0018944157,
-0.0063406923,
-0.0048050303,
-0.017285123,
0.03566112,
0.02305116,
0.0037855848,
-0.039453197,
-0.019726599,
0.0040420694,
0.0021054475,
-0.009402276,
0.0018440927,
0.0024333585,
0.01285021,
-0.034154676,
-0.020648645,
-0.007973753,
0.017414989,
-0.012428147,
0.0020551246,
0.008493216,
-0.011661939,
-0.014415092,
0.00575305,
-0.0072659855,
0.010499641,
-0.006441338,
0.010116537,
0.0113307815,
-0.001719097,
-0.021947302,
-0.033868972,
0.016583849,
0.00264926,
-0.009603567,
-0.010330816,
0.027999043,
0.015791668,
0.022687536,
-0.030726222,
-0.0049965824,
0.0027580226,
-0.020661632,
0.010636,
0.013532005,
-0.004535559,
-0.035219576,
0.009713953,
0.0016671508,
-0.00974642,
-0.00034921695,
-0.0029852875,
-0.0077529815,
-0.0047465907,
0.017168244,
0.03706367,
0.009317863,
0.021051228,
0.00972694,
-0.02218106,
0.01654489,
0.03425857,
-0.013096955,
-0.030414544,
-0.023323879,
0.0327781,
0.026882198,
0.005707597,
-0.016713714,
0.0017548101,
0.054491643,
-0.000009061429,
0.0032076826,
0.014973514,
0.020233074,
-0.012817743,
-0.004743344,
-0.017661734,
0.023479717,
-0.00028631327,
0.00043099176,
0.016181264,
0.029817162,
-0.0017888999,
0.00079542736,
0.00093340967,
-0.0029917809,
-0.0007065505,
-0.0072270255,
-0.04103756,
-0.003254759,
-0.031141791,
-0.025232904,
0.018388981,
0.011038584,
0.017025393,
-0.014557944,
-0.011843751,
0.010239909,
-0.011135983,
-0.02846656,
0.0018570793,
0.009597074,
0.024206964,
0.0048310035,
-0.015648816,
-0.008713988,
0.026180923,
0.012200882,
-0.0049608694,
0.007012747,
0.019544786,
0.0012734954,
-0.008772427,
-0.017272137,
-0.01767472,
-0.021064214,
-0.021090187,
-0.01229828,
0.011447661,
-0.0042628413,
-0.018570794,
0.03470011,
-0.0048082774,
-0.0052660536,
-0.028622398,
-0.0068569086,
0.0034349475,
0.007902327,
0.0006878823,
-0.01067496,
0.020609684,
0.032985885,
0.039427225,
0.031713203,
0.00018556589,
0.0012588855,
0.023336865,
-0.012032056,
-0.009278904,
0.015622842,
0.013109941,
0.02293428,
0.019804517,
0.024427736,
-0.0009163648,
-0.0060225213,
-0.0005076937,
-0.00048537302,
-0.005012816,
0.017960425,
0.018752605,
0.020596698,
0.01737603,
-0.017285123,
-0.0018116264,
0.0072205323,
-0.0019187656,
0.024142032,
-0.031557363,
0.014622876,
-0.0071426127,
0.02123304,
0.02672636,
0.0036687057,
-0.0051881345,
-0.057504527,
-0.0032320323,
0.023245959,
0.0045972452,
0.017285123,
-0.009629541,
0.0023375824,
0.010136017,
-0.039115544,
0.00842179,
-0.026960118,
-0.009610061,
-0.0048861965,
0.007610129,
-0.025375756,
-0.6545231,
-0.0014812805,
0.033920918,
-0.012512559,
0.0069413213,
0.004999829,
0.0010259389,
0.0053472198,
-0.012103482,
0.016999418,
-0.003701172,
0.01547999,
-0.012713851,
-0.0059381085,
0.0015510833,
-0.017739654,
-0.012772291,
-0.0041232356,
0.0004772564,
0.006889375,
-0.03675199,
-0.0046913982,
-0.0037855848,
0.031765148,
0.0007641784,
-0.0065387376,
0.035790984,
-0.0153371375,
0.0011298315,
0.013311233,
-0.01729811,
-0.004412187,
-0.009077611,
0.020414887,
0.045946483,
-0.0033570281,
-0.020856429,
0.044907555,
-0.018337036,
0.025271863,
-0.019479854,
-0.0046232184,
0.015467004,
0.014505997,
-0.009324357,
-0.00036930555,
0.005519292,
0.0010064591,
-0.0069283345,
-0.018648714,
-0.021064214,
0.0065127644,
-0.013999522,
0.009116571,
0.006516011,
-0.008162059,
0.0055030584,
-0.01850586,
-0.010278869,
0.022609616,
0.0062367995,
-0.0063601723,
-0.007649089,
-0.01146714,
0.004710878,
0.015791668,
-0.0004342384,
-0.010402242,
0.0109541705,
-0.013895629,
-0.007856874,
0.021246027,
-0.00068260654,
0.014038481,
0.011103516,
-0.006804962,
0.021284986,
-0.00078649906,
-0.010934691,
0.017700693,
-0.019843478,
0.0010827552,
-0.031323604,
-0.009298383,
0.014285225,
-0.00891528,
-0.029401593,
0.002618417,
-0.015194286,
-0.013687843,
0.007973753,
0.017843546,
0.0060290145,
-0.04436212,
-0.024856294,
0.029375618,
0.006597177,
0.033635214,
0.019648679,
0.007597143,
0.0030469738,
-0.025882231,
0.013493045,
0.016142305,
0.034232594,
0.00096181774,
-0.033505347,
0.011947643,
0.019544786,
-0.0068114554,
-0.0021395371,
-0.02486928,
0.035323467,
-0.018908445,
-0.012648918,
-0.02653156,
0.023336865,
0.022869349,
0.005915382,
-0.054231912,
0.0153371375,
-0.028492533,
0.019661665,
-0.007597143,
0.013233313,
0.022583643,
-0.0043959534,
0.0017872766,
-0.013246301,
0.006688083,
-0.012655412,
-0.0204019,
0.02331089,
-0.016311131,
-0.0041589485,
0.02218106,
0.010428214,
-0.01502546,
-0.014934555,
-0.026674412,
-0.032752126,
0.0053959196,
0.00004306874,
0.0009488312,
-0.023284918,
-0.036466286,
-0.049141176,
0.009739927,
0.006869895,
-0.017960425,
-0.00092853967,
-0.008486723,
-0.012324254,
-0.017895492,
0.023609582,
0.00021143758,
-0.0021996002,
0.0024073853,
-0.0090451455,
-0.027115956,
0.01737603,
-0.012161922,
-0.013856669,
0.013116434,
-0.006051741,
-0.013934588,
-0.0019138956,
-0.008415297,
-0.0021200574,
-0.031063873,
0.032232665,
-0.00038026297,
0.021778475,
0.010441202,
0.0050030756,
0.0121164685,
0.0028440587,
-0.0040680426,
0.003306705,
-0.012941116,
0.017960425,
-0.004772564,
-0.00031431555,
-0.018674687,
0.018635726,
0.008220498,
0.050180104,
-0.005519292,
-0.029609377,
0.014635863,
0.023271931,
0.03127166,
-0.0048212637,
-0.019181162,
0.008155566,
0.019427907,
-0.014635863,
-0.008759441,
0.007785448,
0.0064153653,
0.027791258,
0.002512901,
-0.01012303,
0.0020697345,
0.0033229382,
0.0024349818,
-0.0012921636,
-0.022960253,
0.0047043846,
0.0092334505,
0.010213937,
-0.012109975,
0.0023229725,
0.0035323468,
-0.00069762225,
0.020388912,
0.023271931,
0.02202522,
-0.021752503,
-0.007415331,
0.010661973,
-0.019129217,
0.011720379,
0.0045939987,
-0.0016200745,
0.013830696,
0.0017613034,
0.00794778,
0.00037579885,
-0.005918629,
-0.011285328,
0.033479374,
0.001413101,
0.03358327,
-0.00052189775,
0.0063666655,
-0.011687912,
-0.0052498206,
0.0077919415,
0.020168142,
0.0034706607,
0.04189467,
-0.0012751188,
-0.010233416,
0.026960118,
-0.02134992,
0.012071016,
-0.024999145,
0.0075387033,
0.00057668483,
-0.011512593,
0.004619972,
-0.03358327,
-0.006087454,
-0.00037234928,
-0.00832439,
0.00036687058,
0.00016963706,
0.012317761,
0.05189433,
0.013596938,
0.03342743,
0.0064575714,
-0.011038584,
-0.030232733,
0.008097126,
-0.0017272136,
-0.0055225384,
-0.024830319,
-0.010564574,
-0.009993165,
-0.015220258,
0.015116367,
-0.031557363,
0.029193807,
0.00931137,
-0.00790882,
0.011285328,
0.0022629097,
0.02449267,
0.013103448,
-0.040414203,
0.0027645158,
0.0024301116,
-0.013570964,
-0.019882437,
-0.025025118,
-0.0014691056,
-0.012616452,
-0.018804552,
0.010986637,
0.029453538,
-0.018687673,
-0.011558047,
-0.014518984,
0.030856088,
0.01718123,
0.021181094,
0.006389392,
-0.026362736,
-0.019427907,
0.028830184,
-0.020713577,
-0.0022174567,
0.027115956,
-0.004266088,
0.0006261961,
0.004675165,
-0.00614914,
0.0011517464,
0.019207135,
0.018882472,
-0.006785482,
-0.008259458,
0.0310379,
0.024843307,
-0.0049348962,
-0.008214005,
0.038855813,
0.02024606,
-0.011285328,
-0.035687093,
-0.0034446875,
-0.018609753,
0.050206076,
0.0050712554,
0.01373979,
0.024284884,
0.016635794,
-0.014830662,
-0.029817162,
-0.021479785,
0.02089539,
0.011220396,
-0.036206555,
-0.028908102,
0.004308294,
0.013311233,
0.016791634,
-0.0046686716,
0.004155702,
-0.012954103,
-0.023661528,
0.01502546,
0.010226923,
0.0055225384,
0.0034511806,
0.039920714,
-0.001946362,
-0.013298247,
0.018492874,
0.019583747,
0.006171867,
-0.033141725,
0.0059510954,
0.023401797,
0.00024146901,
-0.0018733125,
-0.0041979086,
-0.017895492,
0.011356754,
0.00034556448,
-0.00031005434,
0.009012679,
-0.0014958904,
0.041998565,
0.00709716,
-0.005535525,
0.006541984,
-0.010376269,
-0.005899149,
0.03849219,
-0.021544717,
-0.008278938,
0.032830045,
-0.010136017,
0.007811421,
-0.01502546,
0.013532005,
0.0010754502,
-0.020830456,
0.0011801545,
-0.007714022,
-0.021220054,
0.008603602,
-0.01903831,
-0.015726736,
-0.0037758448,
-0.02164861,
0.0067919753,
0.0042531015,
-0.019583747,
-0.02544069,
0.0015316035,
-0.0068569086,
-0.018285088,
-0.03963501,
-0.010272376,
0.0074283173,
0.026882198,
0.028258774,
-0.01152558,
0.0024041387,
-0.0062140734,
-0.0019983083,
-0.0057205837,
-0.00027292085,
0.00076093175,
-0.012291787,
0.008512696,
0.028025016,
-0.010960665,
0.0024642015,
0.01725915,
0.026583506,
0.01794744,
0.029193807,
-0.005292027,
-0.0015486483,
0.016453983,
0.029271726,
0.021518745,
-0.008019206,
-0.009642527,
-0.006389392,
-0.04802433,
-0.018791566,
-0.009259423,
0.0032693688,
0.008921773,
0.022271967,
0.021362906,
-0.023258945,
0.0035128668,
-0.003684939,
-0.023245959,
0.000049359107,
0.0034284543,
0.018375995,
0.004983596,
0.019739585,
0.01907727,
0.0074283173,
-0.023349851,
-0.00014579453,
-0.014895595,
0.016661769,
-0.011239875,
0.0022466765,
0.025466662,
0.0035161136,
0.00085467857,
-0.0124930795,
0.014389118,
0.022817401,
0.035167627,
-0.001185836,
-0.03218072,
-0.020830456,
0.005817983,
0.012317761,
-0.011272342,
-0.028752264,
0.005960835,
0.007649089,
0.010071084,
-0.0016703975,
-0.032414477,
0.044673797,
-0.03308978,
0.016363077,
0.005282287,
-0.029271726,
0.023025187,
-0.013135915,
0.017570827,
-0.025947165,
-0.011902191,
-0.017440962,
-0.039686956,
-0.015467004,
-0.0053342334,
0.02789515,
0.020934349,
0.03997266,
0.012317761,
-0.001597348,
0.015363111,
-0.0033343015,
-0.00804518,
-0.008298418,
-0.016661769,
-0.018337036,
0.016505929,
-0.006753016,
0.0042141415,
0.0042595947,
0.016168278,
0.011700898,
0.020505792,
-0.0032774853,
-0.0042076483,
0.005444619,
-0.004084276,
-0.009454222,
0.006363419,
-0.0024788114,
-0.0238823,
-0.0026882198,
-0.011895698,
0.010116537,
0.019726599,
0.0029560677,
-0.019103242,
0.010928198,
-0.014596904,
0.0033537815,
-0.002032398,
0.018531835,
-0.013057995,
-0.016739687,
-0.02544069,
-0.013057995,
0.01941492,
0.008967225,
0.0017580568,
0.018337036,
-0.017285123,
-0.014363145,
-0.002441475,
-0.020285022,
-0.014142374,
-0.028258774,
-0.00398363,
-0.0106944395,
-0.014856635,
-0.019285055,
0.0022353132,
-0.023661528,
0.024090085,
-0.008155566,
0.017350055,
0.0031362565,
-0.006980281,
0.032258637,
-0.0023895288,
0.025843272,
-0.023830354,
0.027453607,
-0.008129592,
-0.0026460134,
-0.010564574,
-0.006753016,
0.0071296263,
-0.011019104,
0.021687571,
0.020908376,
-0.02437579,
0.0036005261,
0.01990841,
0.027791258,
-0.013109941,
-0.036206555,
0.0011842127,
0.026388709,
-0.010889238,
-0.0059121354,
0.0036264993,
-0.0072724787,
0.036180582,
-0.023622569,
0.0061394004,
0.0024593314,
-0.020466832,
-0.023077132,
0.026479615,
0.0035713064,
-0.0054965653,
-0.023297904,
-0.011441167,
0.0047790576,
0.017570827,
-0.03070025,
0.02184341,
0.013077475,
0.006915348,
-0.013077475,
0.0037985714,
-0.0063666655,
-0.010071084,
0.0061945934,
0.004584259,
-0.0069348277,
0.032881994,
-0.03168723,
-0.011824271,
0.024635522,
0.00015583883,
0.0045517925,
-0.013350192,
0.0007625551,
-0.00047644475,
-0.007629609,
0.006350432,
0.014531971,
0.008772427,
-0.017518882,
-0.017622774,
0.0065841903,
-0.0094931815,
-0.013441099,
0.004908923,
-0.00023030868,
-0.030492464,
0.0021671336,
0.014791702,
0.00016639041,
0.01638905,
0.0010965534,
-0.018596767,
0.004564779,
0.022194047,
-0.015531937,
0.036881857,
0.011220396,
-0.0042823213,
0.001243464,
-0.00666211,
-0.0027482826,
-0.04792044,
0.006314719,
-0.027038036,
-0.02077851,
0.01960972,
-0.0028099688,
0.015116367,
0.0050322954,
0.0048310035,
0.0008782167,
-0.018895458,
0.005616691,
0.005136188,
-0.02781723,
0.00031533014,
-0.019064283,
-0.010454188,
0.03833635,
-0.02218106,
0.0034511806,
0.02006425,
0.02032398,
0.0009812976,
-0.023518676,
-0.0034187143,
0.00090256653,
0.0053017666,
-0.02437579,
-0.014804688,
0.020388912,
-0.00075403263,
-0.022245992,
0.006272513,
-0.011772324,
-0.016583849,
0.0034771538,
0.01101261,
0.025791327,
0.010889238,
-0.017570827,
0.00061036873,
-0.013116434,
-0.0019171422,
-0.011213902,
-0.017856533,
-0.027531527,
0.027531527,
0.02524589,
-0.023284918,
-0.0039446703,
-0.004444653,
-0.035816956,
-0.020116195,
0.02346673,
-0.0035258534,
0.0066945762,
-0.008947746,
-0.0028132156,
0.012687878,
-0.0065484773,
0.016233211,
-0.007837394,
-0.016246198,
0.014804688,
-0.029245753,
0.012032056,
0.014674823,
-0.013506032,
0.015415058,
0.017583814,
-0.009175011,
-0.009519155,
0.028596425,
-0.015116367,
-0.02305116,
0.021908341,
0.014739756,
-0.0034641672,
0.02184341,
-0.011759338,
-0.009395783,
0.008869827,
-0.0014074194,
0.00074429275,
-0.040699907,
0.011609993,
0.013103448,
0.013441099,
-0.005434879,
-0.026934143,
-0.0075581833,
0.03527152,
-0.014778716,
0.013278767,
0.014259253,
-0.017700693,
0.005236834,
0.026012098,
0.004100509,
-0.009006185,
0.015090393,
-0.018298076,
-0.0015478367,
0.019505827,
-0.0054511125,
-0.0029479512,
0.00069356395,
0.018999351,
-0.021051228,
0.009071118,
-0.011973617,
0.017090324,
-0.020583712,
0.031972934,
0.013480059,
-0.032258637,
0.010551588,
-0.01654489,
-0.024155019,
-0.017609788,
-0.009006185,
-0.0011249615,
-0.017324083,
0.025193945,
0.0032482655,
-0.010623014,
0.0054576057,
-0.01805133,
0.0030096374,
-0.013415126,
0.019246096,
0.17776015,
-0.03137555,
-0.012642425,
0.0075581833,
0.0028749018,
0.014311199,
0.011486621,
0.010960665,
-0.0039641503,
-0.0040193433,
0.010454188,
-0.015207272,
-0.032752126,
0.00488295,
0.018440928,
-0.0072205323,
-0.015259218,
-0.020908376,
-0.017402003,
-0.014869621,
0.007285465,
-0.03508971,
-0.012785277,
-0.0095711015,
0.014324185,
-0.0017759133,
-0.010136017,
-0.019311028,
-0.0022677795,
0.014272239,
-0.021830423,
0.01816821,
-0.0046978914,
0.016129319,
-0.014557944,
-0.0042401147,
-0.008395817,
-0.006506271,
0.024622535,
-0.00058764225,
0.0041881683,
-0.01718123,
-0.003912204,
-0.013882643,
0.02653156,
0.031193739,
0.016999418,
-0.018363008,
0.00007939055,
-0.0062562795,
-0.046154264,
-0.00972694,
0.009980178,
0.03163528,
0.004210895,
0.018311063,
-0.005509552,
0.045894533,
-0.0023392057,
0.029661324,
-0.042907625,
0.010908718,
-0.017817572,
0.011402207,
-0.011460647,
0.009103585,
0.018609753,
0.009103585,
-0.007960767,
-0.011402207,
0.017765626,
-0.026596494,
-0.032154746,
-0.011863231,
-0.008649055,
-0.017999385,
0.018142236,
0.02134992,
0.030466491,
0.05776426,
-0.0019788283,
-0.00397389,
-0.0038537644,
-0.027791258,
-0.01832405,
0.0050225556,
0.021259014,
0.012928129,
0.009467209,
0.009662007,
-0.00046629898,
-0.027583472,
-0.007597143,
-0.02376542,
-0.000116168914,
-0.030102868,
0.0053342334,
0.005519292,
-0.0098697925,
0.009700967,
-0.026336761,
0.026180923,
0.0421544,
0.0019577253,
0.032907967,
0.002886265,
-0.001683384,
0.029271726,
0.009324357,
-0.023168039,
0.012999555,
-0.009162025,
0.004944636,
-0.010233416,
-0.008869827,
0.015531937,
0.015363111,
-0.005428386,
0.015583883,
0.034232594,
0.003694679,
-0.0018408461,
0.0053959196,
0.005587471,
0.016103346,
-0.01581764,
-0.042829704,
-0.0070322272,
-0.018181197,
-0.005272547,
0.005788763,
-0.033920918,
0.008298418,
0.01767472,
0.0017418235,
-0.032622263,
0.012142442,
-0.021336934,
0.0011622979,
-0.01018147,
-0.0055420185,
-0.008986706,
-0.013402139,
-0.0033959877,
0.023181025,
-0.023973206,
-0.01941492,
0.024622535,
-0.025960151,
0.0025875738,
-0.008889306,
0.0035453334,
0.0076361024,
-0.019557772,
0.022336898,
0.00025384684,
-0.023038173,
-0.01281125,
-0.017622774,
0.028700318,
-0.019220121,
-0.0012061276,
-0.012291787,
-0.020791497,
-0.0034901404,
-0.001719097,
-0.16238406,
-0.005532278,
0.00039548162,
-0.032336555,
0.0004086711,
0.009304876,
0.0035355934,
0.006314719,
-0.023479717,
-0.0059770686,
-0.0006054988,
0.004645945,
-0.042751785,
-0.014791702,
0.0014325809,
-0.0052693,
-0.00800622,
0.02210314,
0.027921123,
0.019324014,
0.025103038,
-0.036959775,
0.022713508,
-0.029089915,
0.008058166,
-0.00009024651,
-0.0019366221,
0.028025016,
0.022284953,
-0.03651823,
-0.0047887973,
0.007324425,
0.023713475,
0.007850381,
0.012382694,
0.0075192233,
0.0028895116,
-0.022064181,
-0.0039057105,
0.009720447,
0.015142339,
0.021479785,
-0.017440962,
-0.0001910446,
0.008317897,
0.014531971,
0.0074477973,
-0.021103175,
0.0036622125,
0.006606917,
-0.0012588855,
-0.021064214,
-0.0015697515,
-0.0036914323,
-0.0062919925,
0.017233176,
-0.0076685688,
0.009058132,
-0.00088552164,
-0.034570247,
0.010850279,
-0.027453607,
0.030570384,
-0.014441065,
-0.006850415,
-0.02267455,
-0.0044965995,
0.016830593,
-0.024999145,
0.011155463,
-0.0018846758,
-0.011934657,
-0.017479923,
-0.037972726,
0.0055679916,
0.008739961,
-0.020843443,
0.0012783654,
0.026882198,
-0.00013676481,
-0.0054316325,
0.012350227,
-0.031089846,
0.0042076483,
-0.008765934,
-0.008246471,
0.008850346,
0.021012269,
0.021246027,
0.00077594747,
0.011324288,
-0.020804483,
0.011311302,
0.0073179314,
0.042595945,
0.013544992,
0.0008554902,
-0.00038493003,
-0.0022353132,
-0.0062270598,
0.0070582004,
0.0010843785,
-0.022804415,
0.027167901,
0.009467209,
-0.0028846415,
-0.016895527,
-0.0031459962,
0.04303749,
-0.013174874,
-0.04550494,
-0.00400311,
0.014752742,
0.021596665,
-0.00974642,
0.029271726,
0.0020648644,
0.004535559,
0.02180445,
-0.013882643,
0.06150439,
-0.007623116,
-0.018739618,
-0.015246232,
-0.025882231,
-0.032907967,
-0.13890435,
-0.040829774,
0.004944636,
0.00887632,
0.0112918215,
0.014220293,
-0.009895765,
0.011298315,
0.0013668364,
0.02036294,
-0.010090564,
-0.019479854,
0.008175045,
-0.0064997775,
0.020310994,
0.00798674,
0.00529852,
-0.006785482,
-0.033765078,
0.033765078,
-0.010051604,
-0.003402481,
0.0035745532,
-0.014428078,
-0.014700796,
-0.010084071,
-0.024622535,
0.008480229,
0.014700796,
0.014999487,
-0.0018229897,
-0.027375687,
0.021012269,
-0.0021119409,
0.0072205323,
-0.012467106,
-0.007207546,
-0.030908033,
0.01654489,
-0.00050079456,
-0.0009171764,
0.03205085,
0.03236253,
-0.01824613,
-0.0073374114,
-0.020908376,
-0.01877858,
0.005519292,
0.017038379,
0.006233553,
-0.022583643,
-0.001374953,
-0.030154813,
-0.010856772,
0.034829978,
0.007954273,
0.018765593,
0.0053829327,
-0.020285022,
0.002240183,
-0.008025699,
0.0033992345,
-0.034907896,
0.024518643,
0.020414887,
-0.021544717,
-0.025869245,
-0.029609377,
0.014142374,
0.00025120896,
-0.003766105,
0.0153371375,
0.01016199,
0.00800622,
-0.015259218,
0.0024382283,
-0.01642801,
-0.020908376,
-0.011363247,
0.013986534,
-0.0029706776,
-0.029453538,
0.037089642,
-0.0017126037,
-0.0042693345,
-0.00040522154,
-0.006181607,
0.011597006,
-0.01502546,
-0.0042888145,
-0.018142236,
0.03285602,
0.020116195,
-0.020674618,
-0.0044414066,
-0.0025956905,
-0.01737603,
-0.0113697415,
0.005343973,
0.013882643,
-0.009739927,
-0.001986945,
-0.03168723,
0.0024463448,
0.011187929,
-0.01502546,
0.015531937,
0.006253033,
0.010246403,
-0.01233724,
0.0013879396,
0.022207033,
0.004444653,
0.0015356618,
-0.0087074945,
0.00438946,
-0.013376166,
-0.020648645,
0.028596425,
-0.03444038,
0.024258912,
0.02971327,
0.026038071,
0.00063999434,
-0.0005182453,
0.0130515015,
-0.019843478,
-0.009785379,
-0.012058029,
0.012986569,
-0.029998975,
-0.0051134615,
-0.004194662,
-0.02857045,
-0.011798298,
0.01105157,
-0.006451078,
-0.0057205837,
0.0062497864,
0.025752366,
0.019622706,
0.0258173,
-0.024168005,
-0.023726461,
-0.0060127815,
-0.019220121,
0.0028554217,
0.0066296435,
-0.021038242,
-0.020947335,
-0.0019496087,
-0.01194115,
0.0052400804,
0.0024155017,
0.006571204,
-0.01654489,
0.008830867,
0.014363145,
0.015856601,
0.006308226,
0.008694508,
-0.032154746,
0.029921055,
0.01923311,
0.011785312,
-0.021934316,
0.02202522,
-0.0016752674,
-0.0034641672,
-0.008499709,
-0.01188271,
-0.0039251903,
-0.025518607,
-0.0025242644,
-0.0006310661,
0.014363145,
0.015804654,
-0.0059510954,
0.008129592,
0.0029544444,
-0.017025393,
0.020713577,
0.0149865,
-0.009551621,
-0.00483425,
0.012921636,
0.046829566,
0.028778236,
-0.0059446017,
0.017908478,
-0.016492942,
0.018843511,
0.019388948,
-0.009356823,
0.014518984,
0.0007349586,
0.006444585,
0.005934862,
-0.029349646,
-0.0014585541,
0.018440928,
0.020921363,
-0.0028489286,
0.005535525,
-0.009993165,
-0.032154746,
0.003402481,
0.021103175,
-0.03005092,
-0.04742695,
0.008636069,
0.007739995,
0.010928198,
0.00798674,
-0.0028489286,
-0.011142476,
-0.015505963,
0.012324254,
-0.009265917,
-0.008454257,
-0.01786952,
0.0005121578,
0.036881857,
0.017596802,
0.024012165,
-0.007090667,
-0.0075516896,
0.0014423208,
0.025388742,
0.001253204,
0.0032742387,
0.016363077,
0.03220669,
-0.018337036,
-0.040959638,
0.00026094887,
-0.025921192,
-0.015389084,
0.011408701,
0.019817505,
-0.01820717,
0.07807525,
-0.010090564,
-0.009837326,
0.012661905,
-0.033843,
0.008733467,
-0.0006753016,
0.025103038,
-0.018856497,
-0.0068634017,
-0.0007933982,
-0.03750521,
0.013233313,
-0.03444038,
0.004340761,
0.020427873,
0.0063309525,
0.034076758,
0.0032580055,
-0.020882403,
0.028596425,
-0.0133891525,
-0.0008299229,
0.0013108318,
-0.017570827,
-0.0019285055,
0.02421995,
-0.007188066,
-0.030752195,
-0.026466627,
0.021778475,
0.00442842,
-0.043323193,
0.0039349305,
0.0014910204,
0.0019674653,
-0.009200984,
0.0016135812,
-0.0027060763,
0.029479511,
-0.033375483,
-0.0014804689,
0.00057019154,
-0.0051491745,
-0.028025016,
-0.00034008577,
-0.008954239,
-0.005490072,
-0.03651823
] |
The DExD/H box RNA helicase retinoic acid-inducible gene I (RIG-I) and the melanoma differentiation-associated gene 5 (MDA5) are key intracellular receptors that recognize virus infection to produce type I IFN. A third helicase gene, Lgp2, is homologous to Rig-I and Mda5 but lacks a caspase activation and recruitment domain. We generated Lgp2-deficient mice and report that the loss of this gene greatly sensitizes cells to cytosolic polyinosinic/polycytidylic acid-mediated induction of type I IFN. | [
-0.03917003,
0.006086781,
-0.03519937,
-0.026788544,
-0.022603255,
0.03519937,
-0.016164346,
0.014125356,
-0.0030920177,
-0.011180897,
0.041665107,
0.0010848892,
0.0020574327,
0.010107745,
-0.004034379,
0.008229731,
0.013159521,
-0.0006665277,
0.016794821,
0.024306882,
-0.02558125,
0.012247342,
0.004319435,
-0.041316334,
0.000052504776,
0.006908413,
0.004275838,
-0.029350694,
-0.021852048,
-0.009544341,
0.02354226,
-0.019531358,
0.006680368,
0.012730259,
-0.005613924,
0.0053691114,
0.016955795,
-0.025541006,
0.012005882,
-0.004570955,
0.021838633,
0.013789997,
-0.0006925181,
-0.005520023,
-0.0057279463,
0.008504726,
0.010704687,
-0.025782466,
-0.03098725,
-0.0044636396,
0.008658991,
-0.019276485,
-0.022992272,
-0.018605765,
-0.012555873,
0.031282365,
0.027499508,
-0.00011559435,
-0.008216316,
-0.015882643,
-0.011489429,
-0.01596313,
-0.02436054,
0.014339987,
0.020845968,
0.025608078,
0.0074449885,
-0.00041605582,
0.0068178657,
0.0017489017,
0.04941863,
0.03120188,
-0.01184491,
0.00037015343,
0.01526558,
-0.016083859,
-0.018324062,
0.001779084,
-0.003682251,
0.0011695675,
0.024964187,
0.00061035494,
-0.0013305402,
0.019585015,
0.015399724,
-0.012099783,
0.001946764,
0.023408117,
0.018015532,
-0.017639928,
0.016714334,
0.018941125,
0.033053067,
0.03385793,
-0.02854583,
-0.0066602468,
0.026332455,
0.017935045,
-0.012005882,
-0.0149168065,
-0.017599685,
0.007914493,
-0.006807805,
-0.010879073,
-0.01703628,
-0.0005843645,
0.009155324,
-0.023703234,
0.0176131,
0.0071699936,
-0.022241065,
0.007009021,
0.01694238,
-0.031121394,
0.011851617,
-0.006341655,
0.028116569,
0.011234555,
-0.018739909,
-0.0045139436,
0.010617493,
0.037104215,
-0.0072706016,
-0.031362854,
0.03053116,
0.0050840555,
-0.0123949,
-0.005738007,
-0.006170621,
0.0010547068,
0.020564266,
-0.00033389265,
0.016808236,
-0.0030752497,
-0.017961873,
0.019745989,
-0.024843458,
-0.011536378,
0.0034776817,
-0.01627166,
0.01201259,
0.035253026,
-0.0046849772,
0.0041886447,
0.0043227887,
-0.0029897331,
0.018270405,
-0.010436399,
-0.017331397,
0.0057916646,
-0.0077468124,
-0.024628827,
0.0105973715,
-0.014353402,
0.012904647,
0.01969233,
-0.022992272,
0.021328887,
-0.01160345,
-0.012032712,
-0.009155324,
-0.0078407135,
0.0035447537,
0.023823963,
0.014702176,
0.029162893,
-0.005194724,
0.0015979897,
-0.0018578935,
-0.009430319,
0.0015141497,
0.017774072,
-0.037748106,
0.013474759,
-0.0066132965,
0.014393644,
0.013072327,
0.016593605,
-0.021878876,
-0.0024917237,
-0.018994782,
0.007948029,
0.018149676,
-0.008316924,
-0.022616668,
-0.0050840555,
0.01773383,
0.003157413,
-0.01395097,
-0.028626317,
-0.001745548,
0.0026946163,
0.005865444,
-0.009007766,
-0.63230085,
-0.029404351,
0.018699665,
-0.0017136888,
0.013152814,
0.024897115,
0.00028547508,
-0.010134575,
0.017505784,
0.030236045,
-0.020282563,
0.010926024,
0.023622748,
-0.02967264,
-0.03514571,
-0.036138378,
0.00023370389,
-0.0048929,
0.020631338,
0.0074584032,
-0.035065226,
-0.0026459892,
0.0008652284,
0.005469719,
-0.011972346,
-0.0026879092,
0.025500763,
-0.017022867,
0.0014563001,
0.031121394,
-0.019424042,
0.021610588,
-0.006606589,
-0.0069956067,
0.057950184,
-0.010972974,
0.01615093,
0.030638475,
0.011704058,
0.029377522,
-0.033294525,
0.018270405,
0.028277542,
0.007880957,
-0.018498449,
0.01727774,
-0.008028515,
0.029136064,
0.013883898,
0.00019932952,
-0.0023257206,
0.018578935,
-0.031040907,
-0.0063517154,
0.0072370656,
0.0046480875,
0.032999408,
-0.019558186,
0.030906763,
0.00066065893,
0.011375406,
0.03407256,
-0.020644752,
-0.02658733,
-0.003967307,
-0.00830351,
-0.00027080308,
0.014031456,
0.0031507057,
0.021811804,
0.024145909,
0.01706311,
-0.007847421,
0.014044871,
-0.0018863991,
0.032167718,
0.0050706407,
0.032596976,
0.001302873,
0.021074014,
0.00040180303,
-0.020309392,
-0.025809294,
0.011402235,
0.011066875,
-0.014004627,
-0.020456951,
0.02402518,
-0.009007766,
-0.008095587,
0.022992272,
0.0062108645,
-0.017331397,
-0.034904253,
-0.025997095,
0.0026107763,
-0.019289898,
0.010060796,
0.002496754,
-0.011945518,
-0.0064355554,
-0.0032831728,
-0.0021898998,
-0.01201259,
0.030718962,
-0.011616865,
-0.03318721,
-0.0017723768,
0.023247145,
-0.0318726,
-0.011268091,
-0.003008178,
-0.0036051185,
-0.0049566184,
-0.007827299,
-0.020443536,
0.024776386,
0.004544126,
-0.0059123943,
-0.03584326,
0.0076730335,
-0.015815571,
-0.008665699,
-0.0064288485,
0.020725239,
0.0020775544,
-0.01210649,
-0.019437457,
-0.005278564,
-0.000027798187,
0.005704471,
0.0078742495,
0.002070847,
-0.02436054,
0.018149676,
0.0035011568,
0.010235183,
0.006391959,
0.00094152277,
-0.041557793,
-0.033992074,
-0.0064288485,
0.001315449,
-0.0119253965,
-0.00868582,
-0.01294489,
-0.010308961,
0.006982192,
0.03611155,
-0.005821847,
0.02491053,
0.0053221607,
0.008840086,
0.008430947,
0.015587525,
-0.019732574,
-0.010101039,
0.0029276914,
-0.0042557167,
-0.0027180915,
0.004302667,
0.008873622,
-0.0049566184,
0.0026996469,
-0.024923945,
-0.006680368,
0.027767796,
0.015735084,
0.009624828,
-0.026721472,
0.0047889384,
-0.0051175915,
-0.021838633,
0.0033519217,
0.026292212,
0.011355285,
0.014809491,
0.010262012,
-0.015815571,
-0.012763795,
0.004292606,
-0.012931475,
0.004369739,
-0.0027683955,
0.019558186,
0.0089474,
0.024508098,
-0.0076126684,
0.035065226,
0.029377522,
-0.0301019,
-0.0058419686,
-0.0010387772,
0.015547283,
-0.003665483,
-0.01301867,
0.03581643,
0.0042791916,
-0.009289468,
0.016472876,
0.017210668,
-0.033723786,
0.012247342,
-0.009497391,
0.008846792,
-0.036192033,
0.0006589821,
-0.030262873,
-0.0012575994,
0.0068044513,
-0.010094332,
-0.015775327,
0.0068882913,
0.008786428,
-0.0006090973,
0.022643497,
-0.0043127276,
0.0045642476,
-0.022308137,
-0.016647262,
-0.0147155905,
0.018485036,
0.025433691,
-0.015708255,
-0.0067373794,
-0.0076126684,
-0.0076797404,
0.020725239,
0.0033250928,
-0.022160579,
-0.016741164,
0.0022905078,
0.012582702,
0.016835064,
0.0018226808,
0.013441223,
-0.012186977,
0.006881584,
0.030906763,
-0.005721239,
-0.011429064,
-0.0049331435,
-0.0001963951,
-0.0016390713,
-0.0055434983,
-0.009457148,
0.027378779,
-0.0013959354,
-0.026386114,
0.026439771,
-0.016888723,
0.012079662,
-0.004067915,
0.002540351,
0.003816395,
-0.029994585,
0.025795879,
0.023086172,
0.033777446,
0.017787486,
0.008088879,
-0.008699235,
-0.003658776,
-0.022791056,
0.02038988,
0.01100651,
-0.013313786,
0.0091352025,
-0.019544773,
0.0043328493,
-0.023193488,
-0.0013833594,
0.021516688,
-0.03739933,
0.008498019,
0.009483976,
-0.00061077415,
0.0017053048,
0.0008358844,
-0.002439743,
0.0057447143,
-0.043489464,
0.02256301,
0.010966267,
-0.015735084,
-0.012374778,
-0.039491978,
0.013119278,
0.0008354652,
0.009671778,
0.0033519217,
0.018498449,
0.0018277112,
0.02918972,
0.0049901544,
-0.015104608,
0.029136064,
-0.01605703,
0.019705744,
-0.0010270395,
0.01311257,
-0.0059761126,
0.0012793979,
-0.0070693856,
0.02732512,
-0.0030299763,
0.006147146,
0.000050565977,
0.0032664048,
-0.011710766,
-0.0039572464,
0.010724808,
0.008410825,
-0.033965245,
-0.0027348595,
0.011281505,
-0.0247898,
-0.0072035296,
0.009832751,
0.015949715,
-0.021999607,
-0.029806783,
0.020108176,
-0.014447303,
0.0141656,
0.028277542,
-0.021328887,
0.022080092,
0.013146106,
0.0026325749,
-0.0021513335,
-0.02686903,
0.019745989,
-0.020081349,
-0.0068212193,
0.008498019,
-0.0060297702,
0.006757501,
0.0132198855,
0.025232475,
0.014433888,
-0.017532613,
0.002790194,
0.0052148458,
0.0052919784,
0.010000431,
0.0015611001,
0.013857069,
0.020295978,
-0.006874877,
0.0032613745,
0.015533868,
0.002689586,
-0.019531358,
0.001399289,
0.011268091,
0.0027616883,
0.006190743,
-0.00564746,
-0.043999214,
0.0033234162,
0.0017220728,
-0.004688331,
0.009919944,
0.0065529314,
0.0092693465,
0.008095587,
-0.0028522355,
0.005211492,
0.007364502,
-0.02857266,
0.008779721,
-0.004453579,
-0.010208353,
0.033777446,
-0.022777641,
0.0007247965,
-0.019531358,
0.0008547484,
0.002095999,
-0.017344812,
-0.0065696994,
-0.0040578544,
-0.023502018,
-0.0039035887,
-0.022522768,
0.005362404,
-0.008290095,
-0.003893528,
-0.014018042,
0.009195567,
-0.030423846,
-0.02902875,
-0.0067340257,
0.0033938417,
-0.03562863,
-0.01301867,
0.013193057,
0.014742419,
0.021516688,
0.026023924,
-0.006425495,
0.035574973,
0.013937555,
-0.01615093,
-0.024467854,
0.023716649,
-0.023823963,
0.020282563,
0.0035414,
0.0027164149,
-0.026909275,
-0.020765482,
-0.012361364,
0.016660677,
0.020255735,
0.025192233,
-0.0010253628,
0.003682251,
0.026761716,
0.015815571,
0.028438516,
-0.014661932,
-0.0052181995,
-0.0022066678,
-0.042201683,
-0.03380427,
-0.01727774,
-0.010013845,
-0.030370189,
0.020617923,
0.016016787,
-0.018310647,
-0.0067709154,
0.001921612,
-0.00028778068,
-0.00042255342,
-0.012810746,
0.009678485,
0.025903195,
0.010355912,
0.012428436,
-0.0055502057,
-0.019745989,
-0.022200823,
-0.019960618,
0.02189229,
0.012233927,
-0.01902161,
0.0092693465,
-0.010979681,
-0.014889977,
-0.017935045,
-0.012173562,
-0.0153192375,
0.019035025,
0.011865032,
-0.023756891,
-0.014393644,
-0.0041651693,
-0.00031167507,
-0.0063014114,
-0.0034676208,
-0.025353204,
0.0028891251,
0.0002100191,
0.015359481,
-0.019410629,
0.009255932,
-0.027056832,
-0.01083883,
0.03458231,
-0.008920572,
0.009430319,
0.006324887,
-0.023005685,
-0.017103352,
-0.019370385,
-0.020765482,
-0.033079896,
0.0033066482,
0.004778878,
0.029806783,
0.026090996,
0.034635965,
-0.014313159,
0.017908216,
0.024253225,
0.01981306,
-0.0012919739,
0.010087624,
0.003658776,
-0.018672837,
0.030289702,
0.018538693,
-0.0028522355,
0.004587723,
-0.01658019,
-0.0051846635,
-0.0074584032,
-0.005966052,
-0.03147017,
0.005536791,
-0.038794428,
-0.033267695,
0.009222396,
-0.015372896,
-0.00758584,
-0.03764079,
-0.0017707,
0.015091193,
-0.013414394,
0.017465541,
-0.009966895,
0.024132494,
-0.009752264,
0.04912351,
0.008994351,
0.018297233,
-0.011026632,
0.004436811,
0.007498646,
0.01550704,
0.012200391,
0.008739478,
0.010818709,
0.009457148,
-0.018203333,
0.025514178,
-0.00082372763,
-0.00990653,
-0.011838202,
-0.02060451,
-0.03211406,
-0.026077582,
-0.03452865,
-0.018163089,
-0.03125554,
0.0022184055,
0.015694842,
-0.02768731,
0.014608275,
-0.004336203,
-0.02558125,
0.019222826,
0.009128495,
0.023032514,
-0.023488604,
0.020980112,
0.019249655,
0.02127523,
-0.02591661,
-0.018766737,
0.01129492,
-0.0058453223,
0.03388476,
0.030289702,
-0.023958107,
-0.0093364185,
0.0010538683,
0.006405373,
0.00973885,
-0.028733632,
0.025098331,
-0.0141656,
0.012508922,
-0.006039831,
-0.014581447,
-0.021302057,
0.013870483,
-0.008363875,
0.029940927,
-0.021181328,
-0.0064154337,
-0.009852872,
0.01615093,
-0.012475386,
0.0039438317,
0.0016726073,
0.0035011568,
0.012334535,
-0.034153048,
0.014058284,
0.010422984,
-0.003115493,
0.027955597,
0.0022905078,
-0.0018109432,
0.0047386345,
-0.0027667189,
0.01615093,
-0.0073712096,
-0.008585212,
0.037533473,
-0.011133947,
-0.006824573,
0.001432825,
-0.0057413606,
0.015533868,
-0.004611198,
-0.003564875,
0.007176701,
-0.026815373,
-0.015372896,
0.016513119,
-0.01737164,
-0.0043462636,
0.016043615,
-0.030745791,
0.00086187484,
-0.027553165,
-0.010134575,
0.03122871,
-0.03917003,
0.0055099623,
0.000049648977,
-0.0002471183,
0.005939223,
0.037023727,
0.008390703,
0.0048929,
0.01572167,
-0.029404351,
0.013266835,
-0.005754775,
0.0020088055,
-0.03785542,
0.0053758183,
0.007599254,
-0.032865264,
0.015654597,
-0.009081544,
-0.01163028,
-0.021610588,
0.0010320699,
0.002387762,
0.011476014,
-0.030075071,
0.0010848892,
-0.0031389683,
0.01672775,
0.0036218865,
-0.00057639973,
0.020859383,
-0.018337477,
0.0010069179,
0.014420474,
0.0061337315,
0.0068346336,
-0.00008960396,
-0.010718101,
-0.008330339,
-0.0194777,
-0.030370189,
-0.010255304,
-0.005094116,
0.0015502009,
0.013038791,
-0.004795646,
0.004540772,
-0.01969233,
0.0072236513,
0.017760657,
-0.01715701,
0.008249852,
0.0032244849,
-0.011556501,
0.00945044,
-0.016767992,
0.0016457784,
-0.0042657773,
-0.02246911,
-0.03281161,
0.0041282796,
-0.03514571,
0.043274835,
-0.0023072758,
-0.0037224942,
-0.0037191408,
0.0040779756,
-0.020121591,
-0.023153244,
-0.007619376,
0.0030065011,
0.009329711,
0.005429476,
-0.008041929,
-0.004792292,
-0.007351088,
0.0020641398,
0.008766307,
-0.019517943,
-0.0022066678,
-0.011865032,
0.01969233,
-0.009872994,
-0.0051377127,
-0.020309392,
0.024065424,
0.010932731,
-0.035414,
0.030799448,
-0.012549166,
0.013991213,
-0.030209215,
0.015614355,
-0.0018511864,
0.012200391,
0.021342302,
-0.022616668,
-0.0067507937,
0.0049566184,
0.018002117,
-0.014460716,
-0.0036688368,
0.010315669,
0.018028945,
-0.0006011325,
-0.0061337315,
-0.013991213,
0.0038130416,
-0.0031842417,
0.011576622,
-0.0036051185,
0.0121266125,
-0.0034978034,
0.011818081,
-0.020497194,
-0.004409982,
-0.00012607434,
-0.012408314,
-0.012099783,
0.023998352,
-0.0028304372,
-0.013052206,
-0.005362404,
0.00056088937,
-0.021234985,
-0.002580594,
-0.013193057,
0.0029478131,
-0.015346067,
0.011522965,
-0.00914191,
0.0007474333,
-0.012307706,
0.0061672674,
0.01134187,
-0.021489859,
0.008544969,
0.010979681,
-0.018739909,
-0.027378779,
0.008102294,
0.0010823739,
0.0009901499,
-0.0135887815,
-0.016767992,
-0.0074047456,
0.016459461,
0.19810377,
0.0036218865,
0.007049264,
0.011355285,
-0.02454834,
-0.005868797,
0.02918972,
-0.012133319,
0.010342497,
0.008088879,
0.036353007,
0.00016757513,
-0.0006015517,
0.0020574327,
0.008773014,
-0.009671778,
-0.018874053,
0.0010983035,
-0.02246911,
-0.01926307,
0.03871394,
0.0027382132,
-0.008169366,
-0.023059344,
0.033750616,
0.018149676,
-0.037023727,
-0.002246911,
-0.006314826,
-0.0079413215,
-0.023676405,
-0.018310647,
0.001382521,
0.008692527,
0.0056508137,
0.013206471,
-0.020135006,
-0.021825219,
0.014635104,
0.002538674,
0.004711806,
0.018350892,
-0.015292409,
-0.0018863991,
-0.0024783092,
0.0072907233,
0.007525475,
-0.022965442,
0.0073577953,
0.016794821,
-0.03943832,
0.0024196212,
0.0023408118,
0.024132494,
-0.015359481,
-0.017210668,
0.0050002155,
0.013085742,
-0.0032563442,
-0.00011957675,
0.0036721902,
0.0071699936,
-0.027794624,
0.02356909,
-0.015104608,
0.04912351,
-0.018941125,
0.005546852,
0.02158376,
-0.049311314,
0.0016357177,
-0.0032278385,
-0.009960188,
-0.0004326142,
-0.017076524,
-0.010080917,
0.021261815,
0.012978426,
0.023555676,
0.018659422,
0.018860638,
-0.007619376,
-0.03122871,
0.018485036,
-0.016459461,
-0.019544773,
0.01981306,
0.010651029,
-0.036138378,
-0.011482721,
0.00084301084,
-0.016539948,
-0.016405804,
0.012314414,
0.009665071,
0.0019853304,
-0.0118918605,
0.0017053048,
-0.0012785594,
-0.019155754,
-0.02445444,
0.071149945,
0.002262002,
0.0052685034,
-0.018431377,
0.017344812,
0.0069017056,
-0.0043999213,
0.007961443,
-0.011851617,
0.03391159,
-0.02591661,
0.004909668,
0.005801725,
0.002354226,
0.02588978,
0.006039831,
-0.03943832,
0.01002726,
0.00036051183,
0.003658776,
-0.020497194,
0.000007964796,
0.047272325,
-0.012287585,
-0.008377289,
-0.024588585,
-0.020805726,
0.01450096,
-0.038231023,
-0.011201019,
-0.00010343755,
0.020591095,
0.0058117863,
0.010094332,
-0.00024879508,
0.03672861,
-0.025514178,
-0.014970464,
0.0064825057,
-0.018967953,
0.0024917237,
0.042201683,
0.0058285543,
-0.0055502057,
-0.0028103155,
0.027083661,
0.023515433,
-0.0193838,
0.005094116,
-0.037372503,
-0.03189943,
0.0054831337,
0.0044334573,
0.018994782,
-0.030879935,
-0.012985134,
-0.0040276716,
0.008028515,
0.0106242,
-0.02558125,
0.007029142,
0.011496136,
-0.0051813098,
-0.017304568,
-0.014179015,
-0.16977257,
0.010671151,
0.022053264,
-0.028277542,
0.031631142,
0.016513119,
0.011060168,
0.0047654635,
0.00039404782,
0.0058453223,
0.01725091,
0.017089939,
-0.022402039,
-0.01856552,
-0.013595488,
0.0062108645,
-0.021167913,
0.032436006,
0.018753324,
0.00020404551,
0.039599292,
-0.035360344,
0.0023190135,
-0.024199566,
0.015788741,
0.0004313566,
-0.005687703,
-0.025715394,
-0.009765679,
-0.01660702,
-0.01294489,
0.030826278,
0.04453579,
0.012435143,
0.042335827,
-0.009396783,
0.015118022,
0.018364305,
-0.01627166,
0.009564463,
0.03313355,
0.0092358105,
-0.00026032308,
0.0064322017,
-0.015842399,
0.03141651,
-0.0033619825,
-0.0057614823,
0.019544773,
-0.0031020786,
0.010557128,
-0.023099586,
0.024749557,
0.0067507937,
0.044240672,
0.016231418,
0.0030417137,
0.0283312,
-0.0023022455,
-0.03232869,
-0.016888723,
-0.017653342,
0.0513503,
-0.013240007,
0.018632593,
-0.021100841,
-0.0017841144,
0.020282563,
-0.027271463,
0.01129492,
-0.011918689,
-0.01505095,
-0.012294292,
-0.008330339,
0.012119905,
0.019678917,
-0.008169366,
0.025849538,
-0.001114233,
-0.0106979795,
-0.014152186,
0.0064858594,
-0.016647262,
-0.024816629,
-0.0052416744,
1.2608744e-7,
0.008363875,
0.024387369,
-0.001265145,
-0.008612041,
0.02570198,
-0.01758627,
0.022670327,
-0.02060451,
0.023421532,
0.019732574,
-0.001315449,
-0.02338129,
-0.00042758381,
0.0045005293,
0.008196195,
-0.015292409,
0.00299141,
0.011596744,
0.0046145516,
-0.012099783,
-0.027928768,
0.012502215,
0.05046495,
-0.020135006,
-0.00990653,
0.0012240635,
0.017774072,
0.018270405,
0.006780976,
0.019625258,
-0.019169169,
-0.0012508923,
-0.003390488,
-0.025634907,
0.054596584,
0.009604706,
0.0032362225,
0.010376033,
-0.0045340653,
-0.006405373,
-0.13789997,
-0.020228906,
0.0178948,
-0.010657736,
-0.026117826,
0.033079896,
0.0032680817,
0.014876563,
-0.0147826625,
0.017505784,
-0.022093507,
0.007009021,
0.000422763,
-0.007042557,
-0.009933359,
-0.0132869575,
0.010355912,
-0.017049694,
-0.013394272,
0.036889583,
-0.014138771,
-0.019115511,
0.004285899,
0.00076671643,
0.010295548,
-0.014179015,
-0.03055799,
0.02021549,
0.01892771,
0.014031456,
-0.0044468716,
-0.0077736415,
0.01737164,
0.005345636,
-0.038982227,
-0.010946145,
-0.0015929593,
-0.025769051,
0.023810549,
0.0017841144,
0.020644752,
0.017800901,
-0.0041651693,
0.011898568,
0.0031909489,
0.0035782896,
0.01395097,
0.0055502057,
0.013816826,
-0.00009578716,
-0.03715787,
-0.033696957,
-0.04094073,
-0.018887468,
0.0032261617,
-0.031040907,
0.016030202,
0.018833809,
-0.0017388408,
-0.01294489,
0.015708255,
0.0015409786,
-0.01256258,
0.0031892722,
0.026023924,
-0.031711627,
-0.01201259,
-0.032436006,
0.032838438,
-0.014889977,
0.015305824,
0.0134546375,
-0.0020809078,
-0.011335163,
-0.011704058,
0.027056832,
-0.021959363,
-0.023394704,
-0.006207511,
-0.02723122,
-0.009175446,
-0.012334535,
0.013843655,
-0.026050754,
0.046386976,
0.00835046,
-0.006331594,
-0.004141694,
-0.008793135,
-0.009584584,
-0.018659422,
0.037372503,
-0.012099783,
-0.010952853,
-0.015493625,
0.018096017,
-0.011717473,
0.0011955579,
0.01328025,
0.022402039,
-0.030611647,
-0.013649146,
-0.06385252,
0.026909275,
-0.021811804,
0.010174817,
0.0093364185,
-0.038150538,
0.0104967635,
-0.016848478,
0.0037292016,
0.015010707,
-0.030504333,
0.0048493035,
-0.020255735,
0.0055938023,
-0.00990653,
-0.035279855,
0.045260165,
0.0020071287,
0.01773383,
0.029699469,
-0.003514571,
0.017908216,
0.005754775,
0.019558186,
-0.002421298,
0.0132534215,
-0.019491114,
0.027244635,
-0.00957117,
-0.00863887,
-0.018847223,
-0.04244314,
-0.016660677,
0.009819336,
-0.007183408,
-0.021074014,
0.0027834869,
0.020295978,
0.03498474,
0.019491114,
-0.008551676,
-0.056340456,
0.014192428,
0.007196822,
0.024092251,
0.015694842,
-0.038391996,
-0.003424024,
-0.0008878652,
-0.025178818,
0.034206703,
0.010416277,
-0.021328887,
-0.021744732,
-0.026023924,
-0.0066099428,
-0.0009976956,
-0.028116569,
-0.00016002952,
-0.020778896,
0.0065126885,
0.0074785245,
0.014487546,
0.0011737595,
0.011449185,
-0.0023491958,
-0.033670127,
0.007042557,
-0.006254461,
-0.027190976,
-0.042174853,
0.014970464,
0.012891233,
-0.0029545203,
0.019799646,
0.01002726,
-0.017452126,
0.0021328887,
-0.0020037752,
0.01550704,
0.0067943907,
-0.010141281,
-0.008544969,
0.0093364185,
0.014111943,
0.0077736415,
-0.012321121,
0.013065619,
0.009430319,
-0.004124926,
0.015332652,
0.021328887,
0.017908216,
0.0020591095,
0.016687507,
0.0038868207,
-0.011234555,
0.012072954,
0.009879701,
0.04094073,
0.012200391,
0.0011427387,
-0.009390076,
-0.025608078,
0.0050840555,
0.054328296,
-0.022334967,
-0.029994585,
-0.002421298,
-0.007243773,
-0.0040243184,
0.0049733864,
-0.003581643,
0.023743477,
-0.008041929,
0.008940694,
-0.0049834475,
-0.008249852,
-0.0078742495,
0.036326177,
0.01715701,
0.033079896,
-0.008826671,
-0.017854558,
0.0071230433,
0.022965442,
0.03431402,
-0.025326377,
0.019625258,
-0.021852048,
0.0035715825,
-0.0028119923,
-0.02359592,
-0.01193881,
-0.000063875574,
0.0022938615,
0.00741816,
0.026734887,
-0.040645614,
0.095081225,
0.024347125,
-0.017344812,
-0.00047495338,
-0.025608078,
0.023394704,
0.009041302,
0.0117912525,
-0.016472876,
-0.036218863,
0.019128926,
-0.015668012,
0.028116569,
-0.020711824,
-0.023153244,
0.012978426,
-0.020175248,
0.018874053,
-0.006472445,
-0.025822708,
0.0153192375,
-0.009470562,
0.0072571873,
-0.0056105703,
-0.031309195,
0.0051746024,
0.024588585,
0.007559011,
-0.0068882913,
-0.02005452,
0.006157207,
0.008048637,
-0.027982427,
-0.011355285,
0.010523592,
-0.023528848,
-0.0035514608,
-0.015761914,
0.019665502,
0.031309195,
0.0043462636,
-0.006408727,
-0.019035025,
-0.027097076,
0.021825219,
0.0093699545,
-0.03742616,
-0.0060599525,
-0.01160345
] |
We demonstrate single-molecule fluorescence imaging beyond the optical diffraction limit in 3 dimensions with a wide-field microscope that exhibits a double-helix point spread function (DH-PSF). The DH-PSF design features high and uniform Fisher information and has 2 dominant lobes in the image plane whose angular orientation rotates with the axial (z) position of the emitter. Single fluorescent molecules in a thick polymer sample are localized in single 500-ms acquisitions with 10- to 20-nm precision over a large depth of field (2 microm) by finding the center of the 2 DH-PSF lobes. By | [
-0.012604266,
0.026125697,
-0.019462768,
-0.005681698,
-0.01661686,
0.041650053,
-0.015902013,
0.005799716,
-0.016401056,
-0.01579411,
0.012543571,
0.024426246,
0.018747918,
0.020555273,
-0.0062785298,
0.015551331,
0.019031161,
-0.012927972,
-0.009663945,
0.0008986188,
-0.023225838,
0.002802072,
0.0046161693,
-0.014769044,
-0.009711152,
0.020649686,
0.024722975,
-0.023050498,
-0.024696,
-0.0015021939,
0.0067168805,
0.0021276865,
-0.02487134,
-0.014957872,
-0.0085242335,
0.0060391226,
0.014391388,
0.02263238,
0.00963697,
-0.015227626,
0.02410254,
-0.00458245,
-0.010250661,
-0.0009778591,
0.00096605736,
-0.0034697137,
0.005870526,
0.0031476947,
-0.014256511,
0.008173553,
0.011902905,
0.011768028,
-0.015645746,
-0.0063695717,
-0.0011515133,
-0.02163429,
0.0053074146,
0.0013858624,
-0.012267074,
-0.028890679,
-0.013406785,
-0.007283364,
-0.023940688,
-0.00082865125,
-0.025248995,
-0.0077082273,
0.0063392245,
0.034528542,
-0.0034798295,
-0.018680481,
0.03266724,
0.016063863,
-0.02599082,
-0.0019574042,
0.01703498,
-0.0031476947,
-0.013528175,
0.018855821,
0.00643701,
-0.021472437,
0.024709487,
-0.028593948,
-0.016603373,
0.0022035548,
-0.0011118932,
0.014418364,
-0.0062380666,
0.04232444,
0.0030600245,
-0.0077419463,
0.037145156,
0.020379933,
0.013487712,
0.0010124213,
-0.010587853,
-0.01304936,
0.011592688,
0.011032948,
-0.0066190944,
-0.027434004,
-0.0066764173,
-0.008719806,
-0.0048454604,
-0.016347107,
-0.017898193,
-0.020474346,
0.018666992,
-0.0056176316,
-0.0031915298,
-0.033800203,
0.00710128,
0.011869186,
0.020798052,
-0.029672965,
0.021418486,
0.0077419463,
0.001122852,
-0.0010545704,
0.0037023767,
-0.011990575,
0.0059042457,
0.022430064,
0.0032471665,
-0.016522447,
0.035580583,
0.014917409,
-0.0068922206,
-0.009117693,
-0.00857144,
0.0038237663,
0.015214139,
0.024642048,
0.02198497,
0.011653382,
-0.020798052,
-0.0030313632,
-0.009178388,
-0.008551209,
-0.021850092,
-0.027069837,
0.026961936,
0.02445322,
-0.021404998,
-0.007674508,
0.012476133,
0.023778835,
0.015942475,
0.006784319,
0.018788382,
-0.009050255,
-0.00045268133,
-0.011154338,
0.015928987,
0.038520902,
0.006440382,
0.021877067,
-0.015065773,
0.04607402,
-0.025437824,
-0.009825798,
-0.022780744,
0.010978997,
0.00064277375,
-0.0014398132,
0.010412513,
0.01222661,
-0.00355064,
0.01738566,
-0.010500183,
-0.007627301,
-0.0029639245,
0.015875036,
-0.010149503,
0.012799839,
0.008409588,
0.00014414992,
0.011215032,
0.0046937237,
-0.0042283977,
-0.029403212,
0.005233232,
-0.0038001626,
0.019004185,
-0.0062346947,
-0.0159155,
0.00842982,
0.0112285195,
0.00083961006,
0.02345513,
-0.010958766,
-0.0010216942,
0.012941459,
0.02268633,
0.0048926673,
-0.64654696,
-0.035553608,
-0.014121634,
-0.04580427,
-0.0017685762,
0.03363835,
-0.0062684137,
-0.002893114,
-0.0083016865,
0.013656308,
-0.016562909,
0.021054318,
-0.012516596,
-0.034258787,
-0.012334513,
-0.017156368,
-0.0071552307,
-0.02221426,
0.0033314647,
-0.0041474714,
-0.012415438,
-0.0051590498,
-0.022416577,
0.0077756657,
0.030482227,
0.015133212,
0.01850514,
-0.016886614,
-0.01037205,
0.022011945,
-0.028270243,
0.018019583,
-0.0035776154,
-0.0039991066,
0.032397483,
-0.027487956,
0.0085444655,
0.020690149,
0.019193014,
0.02964599,
-0.010587853,
-0.005567053,
0.023967663,
0.005189397,
-0.016374081,
0.0084567955,
0.0073575466,
-0.01520065,
0.007728459,
-0.009562788,
-0.008672599,
-0.0057761124,
0.0052534635,
0.0057693687,
0.02044737,
-0.0094548855,
0.013750722,
-0.007108024,
0.0074452166,
0.0005841865,
-0.0060930736,
-0.015875036,
-0.01969206,
-0.02416998,
-0.012705424,
0.000726229,
0.000046732814,
-0.00486232,
0.005233232,
-0.002201869,
0.017763317,
0.033476498,
0.002105769,
0.00088597403,
0.0048353444,
0.019098599,
0.025653627,
0.017156368,
-0.011936625,
0.0089895595,
-0.014930896,
-0.0029521228,
-0.05297973,
0.0013732177,
0.021054318,
0.02039342,
-0.012550316,
0.012064758,
-0.006713508,
-0.004386878,
0.0066190944,
0.0053815967,
-0.01385188,
-0.0398427,
-0.026503352,
0.028432095,
-0.025977332,
0.010156247,
0.008058907,
-0.0051253303,
-0.019260451,
-0.020636199,
-0.0074452166,
-0.0008960898,
0.034879223,
0.0065786312,
-0.0102304295,
0.004255373,
0.031804025,
-0.044536423,
-0.005472639,
-0.011828723,
-0.04267512,
-0.021917531,
-0.0019287427,
-0.03477132,
0.022295186,
0.023171889,
-0.012442414,
0.0021158848,
0.0025390617,
-0.013453992,
0.01969206,
-0.014701606,
0.006679789,
0.019193014,
-0.0087670125,
-0.02133756,
-0.017291246,
0.021850092,
0.010877839,
-0.0037192365,
0.021175707,
-0.018720943,
0.0050646355,
0.016738249,
0.004865692,
0.0036821452,
-0.014175585,
-0.03660565,
-0.029457161,
-0.017291246,
0.010378794,
-0.020352956,
0.00043540017,
-0.025801992,
-0.027946537,
0.002198497,
0.006683161,
-0.032019828,
0.009495349,
0.0067944345,
-0.027460981,
0.027892588,
0.0033095472,
-0.002621674,
-0.0047577904,
-0.031696122,
-0.0119636,
-0.030805932,
0.014445339,
0.010129271,
-0.018774895,
-0.0026351616,
-0.014216048,
-0.016481983,
0.013838392,
0.0051253303,
0.008820963,
-0.023684422,
-0.0011709019,
-0.011774772,
-0.022618892,
0.023117937,
-0.01633362,
0.03752281,
0.0070338417,
-0.015079262,
-0.008072395,
-0.023536056,
0.016468495,
-0.0136225885,
-0.0030785701,
0.0034039612,
0.018235385,
-0.0038541136,
-0.0012804896,
0.022052407,
-0.01355515,
0.024655536,
0.014512777,
0.020865489,
0.012428926,
0.018316312,
-0.0034663419,
-0.011235263,
0.03612009,
-0.02133756,
-0.010392281,
0.015281577,
0.020622712,
0.0022979688,
0.024304856,
-0.008740037,
0.02416998,
-0.048178107,
0.0075463746,
-0.022564942,
0.014337437,
0.031965878,
-0.019071624,
-0.022011945,
-0.027649809,
-0.00026933273,
-0.0063763154,
0.027609345,
0.016522447,
-0.0040935203,
0.00021285294,
0.011424092,
-0.009191875,
-0.005465895,
0.020164128,
0.01950323,
0.0011835467,
-0.0060492386,
0.005755881,
0.017641926,
0.014566728,
0.007006866,
-0.010351819,
0.0017483446,
0.0039552716,
0.018963723,
0.016711274,
0.01093179,
-0.00886817,
-0.0063358527,
0.05079472,
0.016036889,
0.02670567,
0.018572578,
0.011073411,
0.0056850705,
-0.00505452,
-0.0028644528,
0.011768028,
0.01820841,
0.0059548244,
-0.006538168,
-0.018437702,
0.005290555,
-0.013986757,
0.024116028,
0.01661686,
0.034879223,
-0.004771278,
0.009893237,
0.0065145646,
0.016657325,
-0.0009542556,
0.022834696,
0.019894375,
-0.016994517,
-0.0041036364,
0.00262336,
0.010061833,
-0.020258542,
-0.02805444,
-0.012563803,
-0.010857607,
0.009515581,
0.007863335,
-0.026570791,
0.014742069,
-0.024992729,
0.01644152,
0.019381842,
0.013784441,
0.015065773,
-0.027326103,
-0.025586188,
0.0021141989,
0.01791168,
-0.0075059114,
-0.034258787,
-0.0032657122,
0.018424213,
0.00087670126,
-0.0054052,
0.009947187,
-0.023414668,
0.013062849,
0.0062549263,
-0.03145334,
0.0013639448,
0.028728826,
-0.016158279,
0.004208166,
0.008672599,
0.01243567,
-0.013480968,
-0.003503433,
-0.0037158644,
0.031669147,
0.00085225474,
-0.017952144,
-0.019759497,
0.014162097,
-0.014189073,
-0.020501321,
-0.02109478,
-0.014108147,
0.015268089,
-0.004349787,
-0.0073440587,
-0.015767135,
0.0016918648,
0.038844608,
-0.021135245,
-0.020433882,
-0.012031038,
-0.0055400776,
-0.005577169,
0.025667114,
0.027946537,
0.002564351,
0.0016724762,
-0.004140727,
-0.008773756,
0.007283364,
-0.019476255,
0.0239272,
0.015767135,
-0.01131619,
-0.005884014,
0.0036349383,
0.0054996144,
-0.015564819,
0.0035911032,
-0.004811741,
-0.025667114,
-0.008699574,
0.02222775,
-0.0035573838,
-0.00095509854,
0.026071746,
0.0027346334,
-0.011080155,
-0.013332603,
0.002945379,
0.022497503,
0.0030633966,
-0.016724762,
0.00007144272,
0.028486047,
0.034339715,
0.004912899,
-0.005681698,
-0.0134000415,
0.0024159863,
-0.027784685,
-0.000058323814,
-0.0021681497,
-0.010304611,
-0.0065010767,
0.009576275,
0.0016868069,
-0.012766119,
0.009097462,
-0.0152411135,
0.023360716,
-0.013777697,
0.012341256,
0.035958238,
-0.024938779,
0.002619988,
-0.0058772704,
-0.010149503,
-0.0038473697,
-0.0127796065,
-0.03900646,
-0.010210197,
-0.039411094,
-0.0022659355,
-0.022430064,
0.018140972,
-0.011929881,
-0.010378794,
0.013878855,
-0.0046701203,
-0.01502531,
-0.014431851,
-0.02144546,
-0.0042216536,
-0.026247086,
-0.040274307,
-0.0080791395,
0.030185498,
0.0059952876,
0.005594028,
0.018653505,
-0.005985172,
0.0017449727,
-0.008315174,
-0.007977981,
0.000004945933,
-0.03158822,
-0.012024295,
0.024817389,
0.022376113,
-0.03620102,
-0.025127606,
0.017075442,
-0.0006777575,
-0.0069529153,
0.012988666,
0.029457161,
-0.03671355,
0.012570547,
0.013973269,
0.020339468,
-0.0077217147,
-0.012664961,
0.0031831,
-0.03954597,
-0.010641804,
0.00048429315,
0.006959659,
-0.013251676,
0.0028813123,
-0.009171644,
0.00419805,
0.005371481,
0.0031578105,
-0.01838375,
0.019368354,
0.0062549263,
0.033611376,
-0.0016235833,
-0.003510177,
0.0019725778,
-0.006639326,
-0.0012290677,
-0.006504449,
-0.00748568,
0.03865578,
-0.012206378,
-0.012395207,
0.0078093847,
0.008645623,
-0.02104083,
-0.012516596,
-0.011909649,
0.003732724,
0.04855576,
0.010938534,
-0.019071624,
-0.019880887,
-0.0004480449,
-0.016131302,
0.013487712,
-0.011053179,
-0.010709243,
-0.0001735489,
0.0049365023,
0.002429474,
-0.023320254,
0.010439489,
-0.033449523,
-0.008214016,
0.008962585,
-0.0001704931,
0.027730735,
-0.00074224564,
-0.018788382,
-0.007890311,
-0.019314403,
-0.017790291,
-0.035958238,
-0.024035102,
-0.02688101,
0.022416577,
0.020083202,
0.028782776,
-0.005101727,
-0.0076475325,
0.031831,
-0.014404876,
0.0024800529,
0.006440382,
0.010142759,
-0.029106481,
0.03258631,
0.024884827,
-0.0044981516,
-0.001304093,
-0.030077597,
0.032694213,
0.015335528,
-0.018923258,
0.013137031,
0.009394191,
-0.028674874,
-0.016185254,
-0.01484997,
-0.011889418,
-0.004585822,
-0.0023063987,
-0.012847045,
0.023616983,
0.005290555,
-0.0015451859,
0.007478936,
0.024062077,
-0.009529068,
0.03406996,
0.0010090494,
0.030859884,
-0.021526387,
-0.025437824,
-0.010614829,
0.005884014,
0.040112454,
0.00060779,
0.0077824094,
0.019543694,
0.0074924235,
0.023468617,
0.00514219,
0.013683284,
0.000840453,
-0.016832665,
-0.020622712,
-0.0013411843,
-0.02534341,
-0.0075463746,
-0.053842943,
0.015119725,
0.0029689826,
-0.018073533,
0.023117937,
-0.00070220395,
-0.015160188,
0.031507295,
0.012145684,
0.02934926,
-0.012280561,
0.00907723,
0.03536478,
-0.009434654,
-0.03752281,
-0.017412635,
-0.0020349585,
0.00035089123,
0.037145156,
0.03145334,
-0.024547635,
-0.024008127,
0.008530977,
0.009717896,
0.0061537684,
-0.026031284,
0.0054524075,
0.0062549263,
-0.008908633,
-0.012037782,
0.017061954,
-0.032154705,
0.012948203,
-0.032559335,
0.022969572,
-0.019961813,
-0.015119725,
-0.026665205,
-0.0059177335,
-0.007600325,
0.015928987,
-0.0111610815,
0.007964494,
-0.018046558,
-0.01084412,
-0.009704408,
0.017641926,
-0.0016463437,
0.037091207,
0.007755434,
0.015402966,
0.017709365,
0.027150763,
-0.007424985,
-0.027622834,
-0.0007481465,
0.033908106,
-0.019260451,
-0.009677433,
0.024507172,
-0.007148487,
0.010243917,
-0.0042823483,
-0.02216031,
-0.018235385,
0.00570193,
0.017601464,
0.039761774,
0.009353728,
0.0021715215,
-0.018761406,
-0.019557182,
0.016954053,
-0.018707456,
-0.0042351414,
0.0024513917,
-0.041677028,
-0.007849848,
0.0091446685,
0.01738566,
0.02081154,
0.016428033,
-0.0008459324,
0.012058014,
0.02404859,
-0.031075686,
0.010560878,
0.028432095,
0.0151467,
-0.033827182,
0.0028138738,
0.0026098723,
-0.025842454,
-0.009380703,
-0.030563153,
-0.01579411,
-0.017763317,
-0.008928865,
0.020204592,
0.027245177,
-0.008321918,
-0.0015805912,
0.00084508944,
0.015875036,
-0.01803307,
-0.012503109,
0.0063830595,
-0.013663052,
0.01661686,
0.002429474,
-0.023306765,
-0.006973147,
-0.0011776458,
-0.03719911,
0.0045588464,
0.0054422915,
-0.030698031,
-0.011734309,
-0.0036079627,
-0.02653033,
0.012691936,
-0.007971237,
-0.0108104,
-0.015928987,
0.013528175,
0.0013968211,
0.00589413,
0.0038642294,
-0.0067944345,
-0.0075059114,
0.0011295958,
-0.021202682,
-0.0023654073,
-0.0062785298,
-0.012374975,
-0.025680603,
0.0037023767,
-0.016805688,
0.02964599,
0.011154338,
-0.03223563,
-0.011977088,
-0.0051590498,
-0.010675523,
-0.016697787,
-0.004255373,
-0.007984725,
0.0038743452,
0.022794232,
-0.010419257,
0.028081415,
0.006885477,
0.026247086,
0.0057761124,
-0.026152672,
0.021931019,
-0.014755556,
0.006322365,
-0.0031645542,
-0.043295555,
0.0032589682,
0.034798294,
-0.0036821452,
-0.004815113,
0.024696,
-0.010662036,
-0.008038676,
-0.0010933476,
-0.007977981,
-0.0013361264,
0.010945278,
-0.002904916,
-0.01213894,
0.008052164,
0.007202438,
-0.0004391936,
0.0022237864,
0.0013167378,
0.012772863,
-0.009886492,
0.023846274,
-0.025977332,
-0.01502531,
0.01838375,
-0.0113836285,
0.005361365,
0.008665855,
0.013602357,
0.012374975,
0.026975423,
0.016900102,
0.007991469,
-0.005927849,
-0.03401601,
-0.016805688,
-0.006302133,
0.019880887,
0.015456918,
-0.024250906,
-0.0037664433,
-0.013217957,
0.011505018,
-0.02663823,
-0.014162097,
-0.03247841,
0.03258631,
0.008207273,
-0.0048353444,
-0.033908106,
-0.0110059725,
-0.044212718,
-0.0086119035,
0.028782776,
0.019665083,
-0.017574487,
0.01609084,
-0.005243348,
-0.016954053,
-0.019368354,
-0.011053179,
-0.0040294537,
-0.012954947,
0.01974601,
0.19206502,
-0.0016117815,
-0.0016058807,
0.03342255,
0.0041811904,
0.009259314,
-0.0013243246,
-0.0054288036,
0.0024210443,
0.016846152,
0.018761406,
0.013453992,
-0.00857144,
-0.0013563579,
0.016481983,
0.0031409508,
-0.020771075,
-0.007209182,
-0.016131302,
0.00005381913,
0.016765226,
-0.0108508635,
0.009684177,
-0.0073980098,
0.018990697,
0.008477027,
-0.019907862,
-0.0067505995,
0.00070178247,
0.014715093,
0.0073035955,
-0.02840512,
0.0139328055,
0.0047746496,
0.015902013,
0.0026334757,
0.0008455109,
-0.0046127974,
0.015079262,
0.016009914,
0.0026941705,
-0.0015249543,
-0.0032791998,
0.0066056065,
0.020474346,
0.011343165,
-0.0015544588,
-0.0056311195,
0.0065651434,
0.013346091,
-0.026759619,
-0.005132074,
0.0025812108,
0.032694213,
0.010729474,
-0.008820963,
0.01093179,
0.015133212,
0.0038507415,
0.0034697137,
-0.03711818,
0.02528946,
-0.019098599,
0.012219867,
-0.033260696,
0.025127606,
-0.014162097,
0.0050174287,
0.0030499087,
0.009481861,
0.0076475325,
-0.014458827,
-0.014647654,
-0.009083973,
-0.01484997,
-0.013440505,
0.026489865,
-0.011511762,
0.050956573,
0.022254724,
-0.0031493807,
-0.017938657,
-0.036335893,
-0.004592566,
0.0067573437,
-0.021027341,
0.0446713,
0.000055531436,
0.0005319216,
0.0027262038,
-0.0059076175,
0.0052096285,
-0.016468495,
0.011815235,
0.008126346,
-0.017830754,
-0.0042789765,
0.0009677433,
-0.032505386,
0.0025930125,
-0.01385188,
0.047476742,
-0.0013428703,
-0.011444323,
-0.0003414077,
0.0018022954,
-0.009367215,
-0.0033280929,
0.030536178,
-0.0166843,
0.0064707296,
-0.023509081,
-0.0012686879,
-0.005506358,
-0.0068382695,
0.037792567,
0.0037293523,
-0.028566973,
0.029915744,
0.012712168,
0.0018410726,
-0.011080155,
0.0239272,
0.017075442,
-0.0012079931,
-0.009994394,
-0.027609345,
0.0069394275,
0.0049162707,
-0.018194923,
-0.0013327545,
0.01010904,
0.027676784,
0.019125575,
0.012192891,
-0.0020265286,
-0.023387691,
0.0048892954,
-0.034339715,
-0.009131181,
-0.018666992,
-0.017655414,
-0.003928296,
0.0037057488,
-0.010479952,
-0.018869309,
0.014364413,
0.018747918,
-0.0008918749,
-0.016171766,
-0.00355064,
-0.007971237,
-0.005094983,
-0.025437824,
0.0034899453,
-0.04019338,
-0.020231567,
0.0052096285,
-0.0047915094,
-0.0044071097,
-0.014512777,
-0.00053824397,
-0.0014423422,
0.004811741,
0.0052096285,
0.022052407,
-0.17145579,
0.008713062,
0.01574016,
-0.02251099,
0.015133212,
0.0037765591,
0.03153427,
0.008672599,
-0.0067202523,
-0.0050174287,
0.0062110913,
0.0059784283,
-0.029376235,
-0.015187163,
0.003272456,
0.010965509,
-0.011801748,
0.026354989,
0.024035102,
-0.0052130003,
0.030994762,
-0.032451432,
0.025734553,
-0.010513671,
0.005971684,
0.004585822,
0.011424092,
0.016468495,
-0.0006448812,
-0.010412513,
-0.0064302664,
-0.005236604,
0.021108268,
0.0027936422,
0.024911802,
-0.01290774,
-0.004666748,
-0.0017972375,
-0.0025424336,
0.015524356,
0.0013521431,
0.01820841,
0.010304611,
-0.029241359,
-0.009502092,
0.009421166,
0.0016151534,
-0.021647777,
0.013433761,
-0.014890433,
0.023374204,
-0.03585034,
-0.010904815,
0.01484997,
-0.002893114,
-0.012921227,
-0.01609084,
0.040058505,
0.01596945,
-0.015065773,
-0.01467463,
-0.022618892,
-0.006305505,
-0.0025626651,
-0.026948448,
-0.021054318,
-0.0022490758,
0.0069798906,
-0.019476255,
-0.0028779404,
0.0035236645,
-0.014094658,
0.0021091409,
-0.018909771,
0.030967785,
0.00014646811,
0.013784441,
-0.012462646,
0.015119725,
-0.009056998,
-0.015902013,
0.011983831,
-0.0008134776,
-0.013757465,
-0.015335528,
-0.021121755,
-0.025977332,
0.02599082,
-0.010884583,
0.014081171,
0.01803307,
-0.032397483,
0.0198674,
0.0017786919,
0.009515581,
0.02091944,
0.0045419866,
0.015214139,
0.0023738372,
0.01028438,
-0.0053006704,
0.014998335,
-0.010682267,
0.03463644,
0.011720821,
0.0030735123,
-0.017088931,
0.007924031,
0.059184078,
-0.0049870815,
-0.01944928,
-0.0035607559,
0.002242332,
0.029969694,
-0.0044576884,
0.033692304,
0.018666992,
0.007816128,
0.025882918,
-0.041110545,
0.053168558,
-0.011795004,
-0.03023945,
0.037280034,
0.008915377,
-0.023023523,
-0.12322373,
-0.048016254,
-0.01414861,
0.035526633,
0.012563803,
0.02327979,
-0.0060998173,
0.012031038,
-0.014040708,
0.032262605,
0.02121617,
-0.021998458,
-0.011215032,
0.006669673,
0.023697909,
-0.0010520415,
0.008996303,
-0.023724884,
-0.012408694,
0.013905831,
0.003594475,
0.0041778185,
0.018869309,
-0.0036315664,
-0.003456226,
-0.009825798,
-0.015254602,
0.03970782,
0.013460736,
0.003506805,
0.008362381,
-0.018761406,
0.0006031536,
-0.010061833,
-0.010655292,
-0.0138653675,
-0.0033483244,
-0.041865855,
0.028324194,
-0.01054739,
-0.012334513,
0.010958766,
0.016481983,
0.0051152147,
-0.009502092,
0.0044812923,
-0.017844243,
-0.0037934189,
-0.01502531,
-0.001445714,
-0.050767746,
-0.0037765591,
-0.033044893,
0.00787008,
0.025545726,
-0.015902013,
-0.0029032298,
-0.0065617715,
-0.02404859,
0.0051152147,
-0.015011823,
-0.0013015642,
-0.026085233,
0.020433882,
-0.004680236,
0.0003173827,
-0.032370508,
-0.03436669,
0.0028206178,
-0.03717213,
0.005378225,
0.02551875,
-0.0037630715,
0.011673614,
-0.016374081,
-0.0043700184,
-0.017129393,
-0.01261101,
0.0012981922,
0.002896486,
-0.015672721,
-0.0131572625,
0.032154705,
-0.019651596,
0.025667114,
0.006639326,
0.010884583,
-0.004778022,
0.038709734,
-0.014054195,
-0.009178388,
0.0447792,
0.00014162097,
-0.0029959579,
-0.031048711,
0.009778591,
-0.011221776,
-0.0071147676,
0.027595857,
0.010776682,
-0.047449768,
-0.024803901,
-0.055731222,
0.016455008,
0.023832787,
0.0059818,
-0.010102296,
-0.026193136,
-0.010506927,
0.007526143,
0.020015763,
0.009016535,
-0.011734309,
0.0015612026,
-0.01685964,
-0.0011034633,
-0.034690395,
-0.055677272,
0.03954597,
-0.0020383303,
0.010048345,
0.024696,
-0.006302133,
-0.002237274,
0.019894375,
0.023846274,
-0.024331832,
-0.0017736341,
-0.03323372,
0.01785773,
-0.015065773,
-0.0050646355,
0.006723624,
-0.012307537,
-0.0015839632,
0.027730735,
-0.0042250254,
-0.033152796,
-0.00214286,
0.0069933785,
0.022416577,
0.009805567,
-0.010014626,
-0.046478655,
0.0057322774,
0.006393175,
0.0031527525,
0.011039692,
-0.027555395,
-0.00021896456,
0.0029386352,
-0.0014077799,
0.033503477,
-0.0040935203,
-0.000012578871,
-0.022268211,
-0.0092323385,
0.024075564,
-0.010823889,
-0.012267074,
0.011781516,
-0.014283487,
0.035985213,
0.025383873,
0.014890433,
0.0070810486,
0.008584929,
-0.0027514931,
-0.023940688,
-0.004167703,
-0.0070270975,
-0.03730701,
-0.042297464,
0.014984847,
0.019719034,
0.014809507,
0.014715093,
-0.02994272,
-0.010041601,
-0.0023468619,
0.0029656105,
0.0103855375,
0.01287402,
0.006868617,
-0.00068323687,
0.0075059114,
0.02733959,
0.0076205567,
-0.004764534,
0.031075686,
-0.014094658,
0.010365306,
-0.010790169,
0.040948693,
0.013629332,
0.012442414,
0.024547635,
-0.0026907984,
0.0055974,
0.003225249,
-0.00317467,
0.018532116,
-0.009893237,
-0.0042722328,
0.016576398,
-0.02434532,
-0.009765103,
0.015928987,
-0.02840512,
-0.028674874,
0.013103312,
0.029592039,
0.0074317288,
-0.0111948,
-0.007391266,
0.014944384,
-0.023468617,
0.019044649,
-0.001916941,
-0.024304856,
0.013959781,
0.014431851,
0.02321235,
0.0051961406,
-0.007580094,
-0.0039620153,
0.013757465,
0.015632257,
0.03377323,
-0.012462646,
0.016819175,
-0.010102296,
0.021202682,
0.014957872,
0.0022760513,
-0.0077486904,
-0.012428926,
-0.01750705,
-0.0069866343,
0.003041479,
0.008618647,
0.08303035,
-0.005610888,
-0.0025812108,
0.020245055,
-0.04343043,
-0.008288199,
-0.0002316093,
0.009839285,
0.0021883813,
-0.042594194,
0.03436669,
-0.0053141583,
-0.0031392649,
-0.010972253,
-0.007478936,
0.011761284,
-0.037414912,
0.008901889,
-0.034609467,
-0.025491774,
0.029726915,
-0.022376113,
0.01054739,
0.021823118,
-0.006305505,
0.00428572,
0.03158822,
0.02611221,
0.033557426,
-0.011801748,
0.006265042,
0.0025036565,
-0.02994272,
-0.019408816,
0.013224701,
0.0073170834,
-0.004970222,
0.00830843,
-0.0075328867,
0.021283608,
-0.025451312,
0.028135367,
0.014000244,
-0.0066022347,
0.007627301,
0.0059683123,
0.007108024,
-0.014917409,
-0.023090962
] |
In contrast to the cell division machineries of bacteria, euryarchaea, and eukaryotes, no division components have been identified in the second main archaeal phylum, Crenarchaeota. Here, we demonstrate that a three-gene operon, cdv, in the crenarchaeon Sulfolobus acidocaldarius, forms part of a unique cell division machinery. The operon is induced at the onset of genome segregation and division, and the Cdv proteins then polymerize between segregating nucleoids and persist throughout cell division, forming a successively smaller structure during constriction. The | [
-0.008790122,
-0.020855809,
0.003983888,
-0.023772027,
-0.030489007,
0.02773864,
-0.014118097,
0.005210497,
-0.027420757,
-0.009557185,
0.029134555,
0.021878557,
-0.0066651516,
0.016115224,
-0.020689957,
0.021132227,
0.021408645,
-0.015603849,
-0.020040372,
0.017870484,
-0.017455855,
0.004249941,
0.01430468,
-0.038781576,
0.0008664006,
0.030627217,
-0.01679245,
-0.017124152,
-0.002584517,
0.009280765,
-0.007228355,
-0.0017258907,
0.02541672,
0.00062107877,
-0.006312717,
-0.012031134,
0.01329575,
-0.0007346697,
0.01590791,
0.0014511994,
0.015313609,
0.0073389225,
-0.023841133,
0.007553147,
-0.024670389,
-0.0016135955,
0.0044157924,
0.003244467,
-0.0039044174,
0.013717289,
0.026494754,
0.021560676,
-0.020593211,
-0.0023374676,
-0.013046973,
-0.0035157031,
0.0060190223,
0.015133936,
-0.0157697,
-0.018948518,
-0.012183164,
-0.010013276,
-0.016875375,
0.012984779,
-0.010745786,
0.011720163,
0.006744622,
0.013820946,
0.0102966055,
-0.01708269,
0.041269347,
0.034552366,
0.011678699,
0.002964593,
0.011651058,
-0.04613432,
-0.020814346,
-0.018796487,
-0.008624271,
0.0122384485,
-0.0065614944,
-0.020828167,
0.0076429835,
0.00085301156,
0.020178583,
-0.0019245668,
0.016377822,
-0.011775446,
-0.0054419977,
-0.0045229048,
0.02074524,
0.040992927,
0.017207079,
0.03518813,
-0.04190511,
0.013606722,
-0.0025292332,
0.04920257,
-0.01387623,
-0.025181765,
-0.013613632,
0.017165616,
0.008928332,
-0.020689957,
-0.020980196,
0.011727073,
0.0034327775,
-0.005023914,
0.023592355,
-0.015106294,
0.004471076,
0.040108386,
-0.008354762,
-0.046244886,
0.013903872,
-0.026342724,
0.01842332,
-0.005842805,
-0.039362054,
-0.013364855,
0.013662006,
0.027959775,
0.009018168,
-0.042513233,
0.04464166,
-0.0031356271,
-0.017041227,
0.007566968,
0.0010564385,
-0.006630599,
0.026066305,
0.01886559,
0.004146284,
0.0065062107,
-0.015216862,
-0.023910237,
-0.024324866,
-0.00919784,
0.010441725,
-0.023896417,
0.011872193,
0.016142866,
-0.025195586,
-0.00069234305,
0.01677863,
0.017939588,
0.014194112,
0.0044952626,
-0.009999455,
0.0021146047,
0.025637856,
0.0011868738,
0.019584281,
-0.028222373,
0.042596158,
0.015064832,
-0.016087582,
0.008306389,
-0.013185183,
-0.019404609,
-0.0044607106,
0.01212097,
-0.0042741275,
-0.039776683,
0.01592173,
0.023454146,
0.024573643,
0.0052554146,
-0.012618524,
-0.008651912,
-0.0021837095,
-0.000420891,
-0.033916604,
0.017442035,
-0.007822656,
0.009266945,
0.0034085908,
-0.0071454295,
-0.017856663,
-0.035851534,
0.00339477,
0.023108622,
0.03640437,
0.0104140835,
-0.0034327775,
-0.0076429835,
0.021146048,
0.013199003,
0.018188365,
-0.019971268,
-0.03355726,
0.004567823,
0.0026778083,
-0.0030164216,
-0.621832,
-0.031097129,
-0.036819,
-0.011879103,
-0.0014080089,
0.033446692,
0.014733129,
-0.0006504483,
-0.021947663,
0.0034811508,
-0.007408027,
0.012328284,
0.0057149613,
-0.004032261,
-0.004325956,
-0.028692285,
0.0058220737,
-0.0012551147,
0.028388225,
0.0077604614,
-0.00933605,
0.00317709,
-0.0027037226,
0.006326538,
0.00599138,
0.037482407,
0.027987417,
-0.012349016,
-0.012480315,
0.022472858,
-0.017746095,
0.010531561,
-0.010690502,
-0.027379295,
0.042457946,
0.010932368,
-0.0020696868,
0.026176872,
0.014180291,
0.031788178,
0.0069450256,
-0.025306152,
0.0057564243,
-0.016046118,
-0.015838804,
0.008893779,
0.015880268,
0.012031134,
0.015051011,
-0.0053970795,
-0.00416356,
0.005552565,
-0.0294939,
0.027448399,
0.021242796,
-0.0016861554,
0.021408645,
-0.027268726,
-0.0029766862,
0.034524724,
-0.023398863,
0.01445671,
-0.010628308,
-0.031014204,
-0.026328903,
-0.029106913,
-0.03372311,
-0.004602375,
0.008624271,
0.0150924735,
0.0049375333,
0.0057564243,
-0.011215698,
-0.02263871,
-0.0023564713,
0.03651494,
-0.0018036335,
-0.0109531,
-0.010552293,
0.0062159705,
0.010275873,
-0.009301497,
-0.027959775,
0.016557494,
0.014118097,
-0.013192093,
-0.001457246,
0.029687393,
-0.011215698,
-0.016833913,
0.020814346,
0.026245978,
-0.013966067,
-0.029576825,
-0.03181582,
0.01622579,
-0.02232083,
-0.0066997036,
-0.005417811,
-0.036708433,
0.010773428,
-0.025955737,
0.006734256,
-0.014802233,
0.01198276,
0.002987052,
-0.0239517,
-0.00038396317,
0.05182855,
-0.047157068,
-0.022389933,
0.00452636,
0.0025240504,
-0.00067506684,
-0.0016127317,
-0.021339541,
0.016433105,
0.01972249,
0.0023685647,
-0.023094801,
-0.0037454765,
-0.0068137264,
-0.018962339,
-0.014567277,
0.0085897185,
0.016419284,
0.021878557,
-0.0508058,
-0.026052484,
0.013662006,
0.0072214445,
0.0072007133,
0.035575114,
-0.010600666,
0.037592974,
0.031345908,
0.020054193,
-0.011962029,
-0.006568405,
0.0065925913,
-0.013592901,
-0.0013328575,
-0.0046231067,
-0.008375494,
-0.006685883,
-0.01416647,
-0.03463529,
0.022583427,
-0.019694848,
0.008347851,
0.023716744,
0.029632108,
-0.018312754,
0.0058773574,
-0.007345833,
-0.003353307,
-0.0315394,
-0.03355726,
0.0075807893,
-0.01622579,
0.013841677,
-0.010759607,
-0.019515177,
0.021146048,
-0.018133081,
0.021228973,
-0.0038076707,
0.0008862682,
0.0059222756,
-0.021132227,
-0.012010402,
0.000497986,
0.014000619,
0.0018761934,
0.0016325993,
0.008748659,
-0.0072007133,
0.0001050068,
-0.011312445,
-0.005310699,
0.0015099384,
-0.0027538235,
-0.014802233,
-0.017842842,
-0.003045791,
0.005739148,
0.024988271,
0.01518922,
0.01911437,
0.028968703,
-0.006015567,
0.009584826,
0.0029801417,
-0.00076317537,
-0.004149739,
-0.015603849,
0.010476277,
-0.0023772027,
0.01474695,
0.05188383,
0.00091218244,
-0.019390788,
-0.0028039245,
-0.028858136,
0.024214298,
-0.024946809,
-0.0040218956,
-0.020814346,
0.025361437,
0.010890906,
0.014249396,
-0.0071039665,
0.0021422466,
0.008479151,
0.00328593,
0.024656568,
0.011678699,
-0.008230373,
-0.009543364,
0.007836477,
-0.00069536635,
0.0012248814,
0.022417575,
-0.0023080981,
-0.015064832,
0.0067826295,
0.0034241395,
0.031456474,
-0.031898744,
-0.021422466,
0.0096193785,
0.03753769,
0.01212788,
0.014664024,
0.016847733,
0.020938734,
0.0031390823,
0.0102275,
0.018202186,
-0.0044192476,
-0.018312754,
0.02877521,
0.012231537,
-0.005359072,
0.019045264,
0.009239303,
0.019224936,
-0.0213119,
-0.020551747,
0.0034552366,
-0.006703159,
0.011450654,
-0.020524105,
-0.0040218956,
0.0019072907,
-0.0073527433,
0.00015073469,
0.0014555184,
0.02657768,
0.02483624,
-0.0056631328,
-0.00024402609,
-0.00332221,
-0.012839659,
0.0011462747,
0.013599811,
0.008990525,
-0.016308717,
-0.027572788,
0.0011799634,
0.0005670907,
0.0024653112,
0.00007434157,
-0.013178272,
0.012100238,
0.004025351,
0.0023236466,
0.021947663,
-0.0005899817,
0.00018301957,
0.002933496,
-0.016958302,
0.020952554,
0.020924913,
-0.0002474813,
-0.020689957,
-0.055256143,
-0.0010080653,
-0.014594919,
0.023606176,
-0.024711853,
0.020648494,
0.0046161963,
0.034828786,
0.003693648,
-0.0032254634,
0.0053659827,
-0.019902162,
-0.0014140556,
0.017068869,
-0.0254029,
-0.0040564477,
0.0065062107,
-0.004208478,
0.062691815,
0.009184019,
0.006969212,
-0.009881977,
0.0009856062,
-0.054537453,
-0.010918547,
0.0019072907,
-0.0031529034,
-0.00018561099,
-0.024435433,
0.008202732,
-0.013841677,
-0.003693648,
0.020814346,
0.025071196,
-0.009971812,
-0.009964902,
-0.011789267,
0.0030129664,
0.033944245,
0.034054812,
-0.013945335,
0.03692957,
-0.007131608,
0.01955664,
0.006969212,
-0.03665315,
0.014594919,
-0.020924913,
-0.017151795,
-0.014401427,
0.032838568,
-0.011008384,
0.011989671,
0.03123534,
-0.006938115,
0.012321373,
-0.0065407627,
0.023398863,
0.013378676,
-0.014373784,
0.0070763244,
0.030710142,
0.021533035,
0.0037938498,
0.003380949,
0.03416538,
-0.0031010748,
0.012535598,
-0.011996581,
0.00076144777,
0.01708269,
0.016861554,
0.00041808363,
-0.03402717,
0.023578534,
0.033640184,
-0.0014391061,
0.015507102,
0.008575898,
0.002674353,
0.006233247,
-0.024200477,
-0.0051897652,
-0.026342724,
0.0008042063,
0.021228973,
0.0034552366,
-0.019266399,
0.029715035,
-0.029189838,
-0.0076222518,
-0.015520923,
0.02189238,
-0.016101403,
-0.007850298,
0.004609286,
0.005915365,
0.0071661607,
-0.019819237,
-0.030295515,
0.02483624,
-0.020455,
-0.010877085,
0.011291713,
-0.000017478638,
0.0157697,
-0.036819,
0.008776301,
-0.004353598,
-0.038284022,
-0.03112477,
-0.005956828,
0.028070342,
0.0074702217,
0.021146048,
-0.026798815,
-0.007712088,
-0.0007087554,
0.0004966903,
-0.023785848,
-0.0035416174,
-0.026784994,
-0.0131506305,
-0.003634909,
0.009902708,
-0.022265544,
-0.012784376,
-0.00021379277,
0.0006128726,
-0.0064923894,
0.036542583,
-0.007214534,
0.005386714,
0.012943316,
0.05011475,
0.032341015,
0.0010892634,
-0.012577062,
0.010420994,
-0.00919784,
0.0031494482,
-0.0098059615,
-0.0008676963,
-0.009743767,
-0.0037627527,
0.021823274,
-0.0063472698,
0.0037800288,
0.018658279,
-0.0016308717,
0.0030336978,
-0.0042533963,
0.012646166,
0.015963193,
0.0048822495,
-0.0030336978,
-0.019584281,
-0.010144575,
0.02207205,
0.0029594102,
0.022583427,
0.019777775,
-0.022721635,
0.022721635,
-0.0022683628,
-0.031484116,
-0.014981906,
0.018174544,
-0.017110331,
0.034856427,
0.004861518,
-0.03751005,
-0.011333176,
0.0024359417,
0.020109477,
0.00052994693,
-0.003548528,
-0.014511994,
-0.00408409,
-0.013060794,
0.013447781,
-0.006544218,
-0.0042395755,
-0.036293805,
0.0026726255,
0.011222608,
0.0035364346,
-0.003123534,
-0.01912819,
-0.0064198296,
-0.007912491,
-0.015590028,
0.002543054,
-0.03225809,
-0.016820092,
-0.020385897,
0.04862209,
0.030931277,
0.03399953,
0.0069864886,
0.029189838,
0.026771173,
0.007553147,
-0.008700286,
-0.016999764,
-0.004070269,
-0.021118406,
0.01563149,
0.0049168016,
0.003883686,
-0.00007952443,
-0.017759915,
0.0178152,
0.03576861,
-0.010925458,
-0.011512849,
-0.0025914274,
-0.039362054,
-0.023260653,
-0.011789267,
-0.014539636,
-0.026245978,
-0.020924913,
-0.003797305,
0.036017388,
0.031760536,
-0.0058911783,
-0.022459038,
0.017594066,
-0.004232665,
0.026356544,
0.013033153,
0.020786703,
-0.03690193,
-0.0031701797,
-0.018050157,
0.016446926,
-0.0019971267,
0.011664879,
0.010794159,
0.027517505,
-0.008292568,
-0.017925767,
0.015935551,
-0.0018450964,
-0.040384807,
0.0064923894,
-0.034580007,
-0.022721635,
-0.011201877,
0.0032202804,
-0.05431632,
-0.011519759,
0.01065595,
-0.020095656,
0.017704632,
-0.0054523633,
-0.017607886,
0.041518122,
0.01430468,
0.031318266,
-0.005856626,
0.043121353,
0.006229792,
0.008797033,
-0.009308407,
-0.027434578,
-0.007435669,
-0.02438015,
0.013102258,
0.04107585,
-0.0063299933,
-0.00047639073,
0.0020195858,
-0.0064474717,
-0.012563241,
-0.020703778,
0.021671245,
0.011125862,
0.0016282803,
0.0109531,
-0.014207933,
-0.0035727147,
0.011547401,
-0.0044365237,
0.00540399,
-0.02802888,
0.010469367,
-0.005462729,
0.022901308,
-0.0184095,
0.029576825,
0.012148612,
-0.015216862,
0.017497318,
-0.017248541,
-0.011955119,
0.007186892,
-0.010089291,
0.009260034,
0.012894943,
-0.014912801,
-0.00076619873,
0.021381004,
-0.01358599,
-0.019321684,
-0.020330612,
0.041241705,
-0.012245359,
-0.0025292332,
0.012342105,
0.007836477,
0.029659752,
0.0030423359,
-0.0047958684,
0.011222608,
-0.040246595,
-0.012839659,
0.0306825,
0.018381858,
0.009114915,
-0.021546856,
-0.021864736,
0.007947044,
-0.012542509,
-0.013509975,
0.0034811508,
-0.034248304,
-0.0021526124,
-0.009398243,
0.010738876,
0.012342105,
-0.030931277,
-0.011146593,
-0.01590791,
0.044171743,
-0.024131373,
0.018146902,
0.0147884125,
-0.020703778,
-0.03416538,
0.004626562,
0.0025862446,
-0.023606176,
0.011084399,
-0.02672971,
0.0009709215,
-0.01680627,
-0.008824674,
0.020634674,
-0.0043432326,
-0.0051966757,
0.011063668,
-0.003897507,
0.027089056,
-0.011008384,
-0.0044745314,
0.03637673,
0.0026881741,
0.012307553,
0.01737293,
0.0031304443,
0.000096152755,
0.011526669,
-0.026398007,
-0.0020213134,
-0.0143323215,
-0.0294939,
0.00055499736,
0.010849443,
0.0011143138,
-0.018091619,
0.008043791,
-0.0096539315,
-0.01241812,
0.012784376,
-0.0049444437,
-0.021657422,
0.0034068632,
0.0059602833,
0.0011989671,
-0.018464785,
-0.010690502,
0.0068448237,
0.027683355,
-0.023274474,
-0.05188383,
-0.008119806,
-0.0075255055,
0.0397214,
-0.011775446,
-0.0016161869,
0.0055111023,
-0.0013138537,
-0.02772482,
0.0140282605,
-0.01182382,
0.0048822495,
0.017607886,
0.0022251725,
-0.010248232,
0.008707196,
0.0016749259,
0.02073142,
0.0139107825,
-0.00977832,
0.010759607,
0.012376658,
0.0034362327,
-0.020800523,
-0.027655713,
-0.00081154867,
0.018036336,
0.0026017933,
-0.0028194732,
0.018575352,
-0.024891524,
-0.0026225245,
0.00028721654,
-0.010469367,
0.021408645,
0.011464475,
0.026190693,
-0.025527287,
-0.031926386,
-0.00034962676,
-0.017013585,
-0.02175417,
0.012383568,
-0.03712306,
-0.020372074,
0.032534506,
-0.0018727382,
-0.03773118,
0.0029075816,
-0.00438124,
0.013302661,
0.039776683,
0.012072597,
0.019238757,
0.006848279,
-0.024297224,
-0.02541672,
-0.016626598,
-0.03944498,
-0.007919402,
0.009080362,
0.004025351,
-0.016239611,
-0.013233556,
-0.004643838,
0.002112877,
0.008748659,
0.0045609125,
0.01270836,
-0.020385897,
-0.0013319937,
0.015894089,
0.016612777,
-0.026619142,
0.0140282605,
-0.01387623,
0.0035329794,
-0.0038214917,
0.0150924735,
0.00934296,
0.010780338,
-0.013489244,
-0.023578534,
-0.00081586774,
0.0025499647,
0.0021215153,
-0.028236194,
0.011167325,
0.16408227,
0.0061537763,
-0.004367419,
0.021837095,
-0.0007541054,
-0.021118406,
-0.0019245668,
-0.0027762826,
-0.017248541,
0.007269818,
0.010787249,
0.0021180601,
-0.0031114405,
-0.0018295478,
0.021657422,
-0.035575114,
-0.011291713,
-0.0052174074,
-0.01109131,
0.0072836387,
0.013192093,
-0.022389933,
0.008182,
-0.002240721,
0.028001238,
-0.01842332,
-0.0373442,
0.00048502884,
0.004488352,
-0.00069363875,
-0.028236194,
0.0021370638,
0.0031529034,
0.011492117,
0.01680627,
-0.00004721257,
0.001489207,
-0.009460438,
0.010331158,
0.0066616964,
0.01241812,
-0.0031494482,
0.010344978,
-0.0017811744,
0.006088127,
-0.011588863,
0.012888033,
-0.010393351,
0.00087935774,
-0.021104585,
-0.030599575,
-0.0011575043,
0.03665315,
0.029162196,
0.0076775355,
-0.021491572,
0.011595774,
0.015258325,
0.0009709215,
0.03037844,
-0.032368656,
0.024159014,
-0.020137118,
0.020275328,
0.0040979106,
0.013447781,
-0.018022515,
-0.0036141775,
0.009253124,
-0.056997582,
-0.0028488426,
-0.01709651,
-0.026356544,
-0.016446926,
-0.007124698,
-0.0015488098,
0.025167944,
0.019653386,
0.0074011167,
0.0071938024,
-0.012646166,
0.0022078962,
-0.02541672,
-0.0013199004,
0.016889196,
-0.02162978,
0.02729637,
0.023191549,
-0.0150924735,
-0.018202186,
0.00890069,
-0.023357399,
-0.02030297,
-0.0070175854,
0.031594682,
0.018008694,
0.0012387023,
0.004146284,
-0.004042627,
-0.008824674,
-0.0157697,
0.053072434,
0.020952554,
0.02366146,
-0.016764808,
0.033806033,
-0.00876248,
0.0034776956,
0.0143323215,
-0.036321446,
-0.0041531944,
-0.01709651,
-0.0073942062,
0.00008913431,
0.02031679,
0.025610214,
0.01212788,
-0.059982907,
0.034248304,
-0.0120864175,
-0.0057737003,
-0.027876848,
-0.015576206,
0.022555785,
-0.008230373,
-0.0066513303,
-0.006205605,
0.022307007,
-0.022431396,
-0.03997018,
0.016142866,
-0.011789267,
0.003911328,
0.0004154922,
0.009467348,
0.024711853,
0.012563241,
-0.015299788,
-0.012604703,
-0.0070763244,
-0.02221026,
0.033474334,
0.012190075,
0.019750133,
0.0027538235,
-0.0075807893,
0.031014204,
-0.008092164,
-0.022307007,
-0.022099692,
-0.006091582,
0.012190075,
-0.004205023,
0.004820055,
0.005825529,
-0.058047976,
-0.010186037,
-0.032949135,
-0.0014831603,
-0.0022752732,
-0.030737786,
-0.0069173835,
0.024172835,
-0.008748659,
-0.008403135,
0.004982451,
-0.17547074,
0.009750677,
0.002023041,
-0.022818383,
0.024905346,
0.0037800288,
-0.0036625508,
0.022044409,
-0.0031131683,
0.002112877,
0.05721872,
0.018824128,
-0.028554074,
-0.028222373,
0.012881122,
0.010856354,
-0.015355071,
0.021339541,
0.020814346,
-0.0012499319,
0.03225809,
-0.01065595,
-0.028305298,
-0.0136412745,
0.01633636,
0.0061365003,
0.00016185624,
0.0050550113,
-0.011499028,
-0.014048992,
-0.011602685,
0.027683355,
0.013682737,
-0.008416956,
0.001072851,
0.0072076237,
0.01182382,
0.00346733,
-0.009280765,
0.004688756,
0.010483188,
0.015949372,
0.01766317,
-0.018188365,
-0.005096474,
0.022307007,
-0.00919784,
-0.005849716,
0.025098838,
-0.0020126754,
0.013475423,
-0.00817509,
-0.009508811,
0.024670389,
0.041518122,
-0.010013276,
0.011872193,
0.02248668,
-0.0032341015,
0.0072214445,
0.008582808,
-0.031926386,
0.014664024,
-0.0056009386,
0.0016127317,
-0.009764499,
-0.008154359,
-0.001325947,
-0.032202806,
0.031041846,
-0.00042197076,
0.0068586445,
0.0030285148,
-0.028250014,
-0.0042983145,
0.0032392843,
-0.02221026,
0.004001164,
-0.021505393,
-0.018146902,
0.006509666,
0.0072076237,
-0.020828167,
-0.021450108,
0.006513121,
0.0079815965,
-0.0062263366,
0.038090527,
-0.015603849,
0.013530707,
0.009895798,
-0.03623852,
-0.036100313,
0.0006353316,
0.014111186,
0.019059084,
0.000011593938,
-0.016253432,
-0.0018537345,
-0.00933605,
-0.003054429,
0.0051206606,
-0.017649349,
0.027807744,
0.041573405,
0.0042361203,
-0.025693139,
-0.0016377822,
0.04947899,
-0.0023823855,
-0.01066286,
-0.008727928,
0.023094801,
0.010545382,
-0.0074425796,
0.0011808272,
-0.007573879,
-0.020703778,
0.001737984,
-0.008057612,
0.058324393,
0.0070037646,
-0.02030297,
0.016889196,
-0.002204441,
-0.0076844464,
-0.12626816,
-0.01928022,
-0.012494136,
0.044005893,
-0.022666352,
0.0057909763,
0.0009691939,
0.028236194,
-0.03375075,
0.028097983,
0.01650221,
-0.017497318,
-0.016129045,
-0.00086208154,
0.013344124,
0.008258016,
-0.014539636,
0.0038387678,
-0.023758207,
0.008085254,
-0.0016585136,
0.008790122,
0.012950227,
-0.00933605,
0.004046082,
0.005269236,
-0.017400572,
0.013779484,
0.036017388,
0.01708269,
0.009577916,
-0.018216006,
-0.00078779395,
0.0066547855,
0.0039804326,
-0.028692285,
-0.0011575043,
-0.022749279,
0.026923204,
-0.02598338,
0.017704632,
-0.012355926,
-0.0029680482,
-0.00876248,
-0.008271837,
0.0147884125,
-0.0028937606,
0.011208788,
-0.011194967,
-0.014857518,
-0.04442052,
-0.02031679,
-0.01664042,
0.010586845,
0.0039044174,
-0.041435197,
0.025610214,
-0.0011212243,
-0.0014607012,
-0.017870484,
-0.014650203,
0.014007529,
0.012777465,
0.009902708,
0.019542819,
0.009108003,
0.00020623443,
-0.011754715,
0.01737293,
-0.04173926,
0.005144847,
0.012355926,
-0.031954028,
0.008064522,
-0.0025948826,
-0.000035956054,
-0.03051665,
-0.02162978,
0.011955119,
-0.013081525,
-0.008271837,
-0.019708669,
0.026356544,
-0.023785848,
0.03140119,
0.0031269891,
-0.00612959,
-0.0018710106,
0.01928022,
-0.016516032,
-0.0045021735,
0.0035865356,
0.0019815783,
-0.022790741,
-0.022127336,
-0.005428177,
-0.010939279,
0.012210806,
-0.011236429,
-0.025624035,
-0.035906818,
-0.03375075,
-0.062857665,
0.015714416,
-0.0024877703,
-0.01313681,
0.00029067177,
-0.021933842,
0.003277292,
0.005431632,
0.006834458,
0.021864736,
-0.024200477,
0.023467967,
-0.011340086,
-0.02979796,
-0.02816709,
-0.035409264,
0.030627217,
-0.006751532,
0.027337832,
0.009543364,
-0.0057426034,
-0.0001602366,
0.013129899,
0.032589793,
-0.03900271,
-0.009066541,
-0.0008309844,
0.015659133,
-0.012431941,
0.010517741,
0.008513703,
-0.044171743,
-0.008755569,
0.007428759,
0.0058980887,
-0.017511139,
-0.009757589,
0.020455,
0.013917693,
0.04936842,
-0.009612468,
-0.060204044,
0.013461602,
0.013157541,
0.011858372,
-0.0037040135,
-0.016239611,
0.017345287,
0.0038629544,
0.00876939,
0.029549183,
0.0062781647,
0.006450927,
-0.028664643,
-0.009398243,
0.008202732,
0.0040806346,
-0.020482643,
0.010711233,
-0.021809453,
0.05580898,
0.036321446,
0.034662932,
-0.016267253,
-0.009916529,
-0.011554311,
-0.01445671,
-0.021491572,
-0.01286039,
-0.051026933,
0.0018571897,
0.013883141,
0.021118406,
0.006371456,
-0.002050683,
-0.007345833,
-0.008244194,
0.0150924735,
-0.011319355,
0.0008262335,
0.0007644711,
-0.006810271,
-0.0035139755,
0.014995727,
0.029576825,
-0.0006042345,
0.017345287,
0.0049375333,
0.0070037646,
0.0027175436,
-0.0032686538,
0.031871103,
0.018824128,
-0.020510284,
0.0025171398,
0.034801144,
-0.020399718,
0.000011998849,
-0.00090181676,
0.008534434,
-0.01842332,
0.027130518,
-0.0011514575,
-0.008182,
-0.000982151,
0.014525815,
0.008603539,
-0.033197913,
-0.02642565,
0.012169343,
0.012452673,
-0.00007110229,
0.012245359,
0.006907018,
0.011865282,
0.0038353126,
-0.013019332,
-0.034275945,
-0.005635491,
0.003634909,
0.021519214,
0.029079271,
0.0065200315,
0.011754715,
0.014774592,
0.010241321,
0.021063123,
-0.012058776,
0.0077811927,
-0.013516885,
0.018962339,
-0.012452673,
-0.0074978634,
-0.031180056,
-0.007186892,
-0.0075600576,
0.008057612,
0.016115224,
-0.026038663,
0.06943644,
0.006951936,
-0.022541964,
0.010766517,
-0.015755879,
0.018285112,
0.012252269,
0.0032651986,
0.018326575,
-0.027365474,
0.027849207,
-0.0053798035,
0.000339477,
-0.0069761225,
0.0002945589,
0.009412064,
-0.017179437,
0.016944481,
-0.00816818,
-0.016267253,
0.009101093,
-0.026080126,
0.026259799,
0.018658279,
-0.014926622,
-0.019003801,
0.024698032,
0.0008728792,
0.0061019477,
-0.03930677,
-0.004702577,
-0.026480934,
-0.026052484,
-0.015880268,
-0.015355071,
-0.0045781885,
-0.0072421758,
-0.012024224,
0.00905272,
0.007255997,
-0.026439471,
0.0057737003,
-0.012749823,
-0.017870484,
0.010130754,
0.0009735129,
0.0045574573,
-0.01810544,
0.012065686
] |
Down syndrome (trisomy 21) is the most common viable chromosomal disorder with intellectual impairment and several other developmental abnormalities. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from monozygotic twins discordant for trisomy 21 in order to eliminate the effects of the variability of genomic background. The alterations observed by genetic analysis at the iPSC level and at first approximation in early development illustrate the developmental disease transcriptional signature of Down syndrome. Moreover, we observed an abnormal neural differentiation of Down syndrome iPSCs in vivo when formed teratoma in NOD | [
-0.039318945,
0.019965818,
0.035349756,
-0.030315014,
-0.020059055,
0.016356254,
-0.029062986,
0.002941928,
-0.018340848,
-0.016849073,
-0.0030068604,
0.011787692,
-0.006479901,
0.013865522,
-0.00949675,
0.027757684,
0.023935007,
-0.014664687,
0.00949675,
0.0031949973,
-0.02041868,
0.01554377,
0.014491535,
-0.015397256,
-0.0019795997,
0.016143143,
0.009063869,
-0.022123566,
-0.011274894,
-0.015184145,
0.026106074,
0.0073456634,
-0.0057839607,
-0.015197464,
-0.0013386023,
-0.018167697,
0.015130867,
-0.021044692,
0.019326486,
-0.0162497,
0.001971275,
0.018633876,
-0.023269037,
0.0035429671,
-0.00026513982,
0.01786135,
-0.018367488,
-0.0112216165,
-0.007831822,
0.012906523,
0.010282597,
0.012187274,
0.006749619,
-0.00074963394,
-0.010802054,
-0.008524433,
-0.0032116466,
0.008950654,
0.009456792,
-0.006846185,
-0.0007296548,
-0.010042847,
-0.03361823,
0.014198508,
-0.01459809,
0.008191447,
-0.0037028003,
-0.003316537,
0.016103186,
0.005267833,
0.04427377,
0.00017440123,
-0.01297978,
-0.024521062,
0.01879371,
-0.0055508707,
-0.029169543,
-0.006776258,
-0.010762095,
0.021910455,
0.019433042,
-0.020045735,
-0.010329215,
0.0039059215,
0.009170424,
0.019845944,
-0.004498636,
0.032632593,
-0.009197064,
-0.008684265,
0.009403515,
0.041796356,
0.006146915,
0.0040024873,
-0.024947284,
-0.001033088,
-0.005357739,
0.03732103,
-0.0061335955,
-0.017315254,
-0.005873867,
0.016276337,
-0.0029302735,
-0.019419722,
-0.010868651,
-0.0070459764,
0.027038435,
0.017035546,
0.004938177,
-0.008764182,
-0.013199551,
0.032765787,
0.014931076,
-0.018700473,
0.03644195,
-0.0009814752,
0.0036029047,
0.015330659,
-0.002640576,
0.001635792,
0.04054433,
-0.0088108005,
0.023708578,
-0.030288374,
0.011900906,
0.020232208,
-0.048083127,
0.007378962,
-0.017555002,
-0.0009007262,
0.030288374,
-0.013106314,
0.017328573,
0.024427827,
-0.018167697,
-0.019206611,
-0.0065265186,
-0.01275335,
-0.016702559,
-0.021723984,
-0.010775415,
0.037374306,
-0.0070592957,
0.0037693975,
0.009230362,
0.025813047,
-0.0018863636,
-0.0062767793,
0.011048463,
-0.007072615,
-0.0067129903,
-0.014491535,
0.0154505335,
-0.0011055124,
0.007279066,
0.031567037,
0.034950174,
0.007671989,
-0.006190203,
0.013026399,
-0.0123004895,
-0.024041563,
-0.023855092,
0.013632433,
0.020378722,
0.028823238,
-0.020844901,
0.00092486764,
-0.0018131068,
-0.025666533,
-0.016422851,
0.0129931,
-0.017115463,
0.013785605,
0.009456792,
0.007139212,
-0.017808072,
0.008384579,
-0.028343737,
-0.016835755,
-0.012114017,
0.02805071,
-0.009330258,
0.010282597,
-0.015383936,
0.008990612,
0.017115463,
0.017421808,
-0.018194335,
-0.011214957,
-0.010176041,
-0.012167295,
0.008630988,
-0.012646794,
-0.62995553,
-0.031966623,
0.0050713713,
0.0011446382,
0.011448046,
0.054876033,
0.012606836,
-0.0057606515,
-0.016702559,
0.014051994,
-0.004978135,
-0.0018846988,
-0.00043829234,
-0.0047184066,
-0.0018031172,
-0.025253631,
-0.0074189203,
-0.0070193373,
0.021963732,
0.014504855,
-0.025826367,
-0.0035629463,
-0.024547702,
-0.0034364117,
-0.004598532,
0.018687153,
0.01623638,
-0.008890716,
-0.016143143,
0.030528124,
-0.026598893,
-0.0018047822,
0.0009523389,
0.002572314,
0.040411137,
0.0064499318,
-0.013399342,
0.043447968,
0.014931076,
0.033511676,
-0.02642574,
0.015264062,
0.029036349,
-0.00093069486,
-0.0028170585,
0.043501243,
0.0039791786,
0.0013086336,
0.0019845944,
-0.004814972,
0.015743561,
-0.005937134,
-0.007871781,
-0.017541684,
0.02316248,
-0.021883816,
0.025786407,
-0.0021261133,
0.046511434,
-0.006093637,
-0.010775415,
0.00053943676,
0.0025706491,
-0.012200594,
-0.010142743,
0.004964816,
-0.0139054805,
0.0067562787,
0.008351279,
-0.020538554,
0.0100228675,
0.03686817,
-0.0048815697,
-0.010049507,
0.00858437,
0.03036829,
0.0070326566,
0.0010164387,
-0.0075054965,
0.020085694,
0.000234963,
-0.0065964456,
-0.002109464,
-0.0011063447,
0.025213672,
0.0070592957,
0.0063467063,
0.03292562,
-0.012673434,
0.004888229,
0.018474044,
-0.0034930194,
0.018287571,
-0.032392845,
0.0012220573,
0.014331702,
-0.008151488,
-0.01718206,
0.01736853,
0.014664687,
-0.029862152,
-0.01042911,
-0.013406002,
0.0030717924,
0.029515848,
0.020099014,
-0.03665506,
0.0053743883,
0.047710184,
-0.010975206,
-0.013312766,
0.0016724204,
-0.009763139,
-0.0044919765,
0.022629704,
-0.01275335,
-0.015570409,
0.0019662802,
-0.011268234,
-0.011914226,
-0.009210383,
-0.0018280912,
-0.003686151,
0.0053910376,
-0.009889673,
-0.0029319385,
0.007518816,
0.0017581641,
0.008178127,
-0.020698387,
-0.004059095,
-0.0059737624,
0.021044692,
-0.033245288,
0.029036349,
-0.008218085,
0.0097498195,
0.008997272,
-0.0093502365,
-0.0071125734,
-0.028103989,
-0.013246168,
0.01414523,
0.016582685,
-0.008184787,
-0.011747734,
0.00032778273,
-0.010788735,
0.007871781,
-0.0041589905,
-0.00093402475,
-0.0023791825,
-0.012866565,
0.039239027,
0.015597047,
-0.00905055,
-0.0007916734,
-0.03758742,
0.01068218,
-0.023308994,
-0.007219129,
0.022523148,
-0.008044933,
-0.01599663,
-0.0011288213,
-0.028769959,
-0.012726711,
0.0011504653,
-0.020432,
-0.0064599216,
-0.009656584,
-0.0055109123,
-0.0035096686,
-0.009423493,
-0.005271163,
0.0024324602,
0.0077119474,
-0.01413191,
0.0020495267,
-0.0052511836,
-0.015104229,
-0.013825564,
-0.022762898,
-0.025666533,
0.025666533,
0.0065997755,
0.014345021,
0.005038073,
0.0001226844,
0.0436078,
-0.0058405683,
0.039718527,
-0.009902993,
0.022363316,
0.019379765,
0.01530402,
0.011181658,
-0.00078626233,
-0.004375431,
0.042941827,
0.02922282,
-0.00014099861,
0.0059937416,
-0.006776258,
0.019433042,
-0.05290476,
0.012786648,
-0.015983311,
-0.015477173,
0.033405118,
-0.0100162085,
0.028077349,
0.001994584,
-0.01228717,
-0.0066863517,
0.019606195,
0.0042555565,
-0.010009549,
-0.00058522227,
-0.024920646,
0.0037860468,
-0.008158148,
0.02153751,
0.0045818826,
0.009443473,
0.0044153896,
0.025839686,
0.023282357,
0.017701516,
-0.0047783437,
0.0023308995,
0.022736259,
0.029089626,
0.002250983,
0.013732328,
0.016742518,
0.0059704324,
-0.015343978,
0.046724547,
0.00018178935,
-0.0081448285,
-0.0063700154,
0.018194335,
-0.008184787,
0.000044406755,
-0.018247614,
0.024654256,
0.013785605,
-0.01736853,
0.026225949,
-0.027890878,
0.012493622,
-0.027731044,
0.0039758487,
0.0097365,
-0.005817259,
-0.008018294,
0.021404317,
0.03178015,
0.018141057,
-0.0011612874,
-0.020698387,
0.005584169,
0.0027937496,
-0.006240151,
-0.015463853,
0.0071924897,
-0.00811153,
0.001565865,
-0.018220974,
-0.023482148,
0.0140386745,
-0.0033481705,
-0.03223301,
-0.011314852,
-0.00533443,
0.00266555,
0.01160788,
0.04493974,
0.010289256,
0.009063869,
-0.021444276,
0.017208697,
0.026159352,
-0.010249298,
0.0041057128,
-0.00010884468,
-0.008504453,
-0.010642221,
0.019965818,
0.005937134,
0.013199551,
0.020165611,
0.016782476,
-0.002297601,
-0.03622884,
0.0135724945,
-0.011801011,
0.0059870817,
0.01321287,
0.020072374,
-0.004452018,
-0.028876515,
0.0068861432,
0.025120437,
0.0115879,
-0.024148118,
-0.015290701,
-0.02067175,
-0.026625533,
-0.0025556649,
-0.027278183,
-0.015463853,
-0.009443473,
-0.01415855,
-0.0089439945,
0.0035296478,
0.000002396586,
0.026399102,
-0.010169381,
-0.026585573,
-0.022669662,
-0.025000561,
0.0014027021,
0.030448208,
0.034017812,
-0.019979138,
0.0096832225,
0.0021694014,
0.008650967,
0.0036362032,
-0.022882773,
0.026625533,
-0.0050081043,
0.004615181,
-0.02041868,
-0.0044719973,
-0.012740031,
-0.0013169582,
0.029702319,
-0.00046409873,
-0.01900682,
0.0027721054,
0.009290299,
-0.0066597126,
0.0008599354,
0.02898307,
0.038946,
0.028849876,
-0.014531493,
0.018514002,
0.013132954,
-0.014904438,
-0.0052345344,
-0.029062986,
-0.004828292,
0.00016305891,
0.01718206,
-0.01715542,
-0.0035529567,
0.03220637,
0.015090909,
-0.0011829315,
0.01831421,
0.024973923,
-0.0024158107,
0.007538795,
-0.013878842,
0.003729439,
0.013492578,
-0.030075263,
0.0059937416,
-0.0039292304,
-0.0283171,
0.027890878,
-0.021510873,
-0.007232448,
-0.002434125,
-0.0062301615,
-0.0002899056,
-0.0071924897,
-0.031593677,
0.0067529487,
-0.008084891,
0.008890716,
-0.027624488,
0.0072457674,
0.016129825,
-0.0070326566,
-0.034870256,
0.0041822996,
-0.005214555,
-0.032845702,
-0.02433459,
0.008264704,
-0.009669903,
-0.030687956,
-0.007145872,
0.012000803,
0.0014301733,
0.0071525318,
-0.0033531655,
0.009823076,
0.02922282,
0.010855332,
-0.03321865,
0.00048241296,
-0.007791864,
0.019419722,
0.017608281,
0.02087154,
-0.009756479,
-0.018673835,
0.007865121,
0.012353768,
-0.015170826,
-0.024547702,
0.00028740824,
0.0028686712,
0.026185991,
0.023841772,
0.015610367,
-0.013552516,
0.0012295495,
-0.016502768,
-0.02152419,
-0.025360186,
-0.023815133,
-0.022083608,
-0.024467785,
-0.0025606595,
-0.0024174757,
-0.025826367,
-0.031114178,
0.031620316,
-0.012466982,
0.020218888,
0.0060004015,
0.035562865,
0.01323285,
-0.008018294,
0.020378722,
0.0016707554,
-0.017328573,
0.0013843878,
-0.024387868,
0.032179732,
-0.003686151,
-0.012167295,
0.0044620074,
0.00007518192,
-0.018021183,
-0.028956432,
0.00092486764,
0.017555002,
0.02155083,
-0.007219129,
0.009609966,
0.0047816737,
0.0032332905,
-0.0015700273,
0.022416594,
0.0076586697,
-0.023375591,
0.02898307,
0.023641981,
-0.0036761614,
-0.020698387,
0.019060098,
-0.03180679,
0.006623084,
0.021710664,
0.001088863,
0.013186231,
-0.0029835512,
0.009989569,
-0.010515686,
-0.004515285,
0.0015625351,
-0.039585333,
0.005500923,
-0.023522105,
0.04102383,
0.0436078,
0.024454465,
-0.0030002007,
0.017488405,
0.019153334,
0.003732769,
0.0049082083,
-0.0057706414,
0.0053976974,
-0.008058253,
0.018354168,
0.0061369254,
0.007605392,
0.013152933,
-0.03316537,
0.025826367,
0.02850357,
-0.009183744,
-0.019179974,
0.04520613,
-0.0357227,
-0.01903346,
-0.017821392,
0.007025997,
0.008664287,
-0.026705448,
0.0134393005,
0.013339405,
-0.0035995748,
-0.006543168,
0.0023991615,
0.02485405,
-0.0250272,
0.01321287,
0.013892161,
0.025586616,
0.00029698157,
-0.019512959,
0.003198327,
0.0012437013,
0.023961646,
0.0011196642,
0.042329136,
0.015716922,
-0.00927698,
0.011980823,
0.031433843,
-0.01993918,
0.0071059135,
-0.02296269,
-0.026865281,
-0.003729439,
-0.031913344,
-0.019899221,
-0.04427377,
0.0063467063,
0.012220573,
-0.010235978,
0.01554377,
-0.011880928,
-0.0025406803,
-0.02204365,
0.002226009,
-0.0014884458,
-0.009836396,
0.017634919,
0.002479078,
0.0018930234,
-0.033032175,
-0.024694216,
0.008890716,
0.0007350658,
0.047283962,
0.0041390117,
-0.013605793,
-0.022922732,
0.004298845,
0.0083446205,
-0.032099817,
-0.03087443,
-0.012253871,
0.00086326525,
-0.015876755,
0.0040424457,
0.0056474363,
-0.0038293349,
0.020272166,
-0.03385798,
0.009649924,
-0.021257803,
-0.006559817,
-0.012200594,
0.000498646,
-0.019512959,
0.027264865,
0.012080719,
0.013339405,
-0.011847629,
-0.03915911,
-0.0052445238,
0.01068218,
0.0051113297,
0.022416594,
-0.018860307,
0.0063000885,
0.0089439945,
0.0019080078,
0.00070801075,
-0.0039591994,
-0.019313168,
0.04496638,
-0.0051512877,
-0.0069593997,
0.004515285,
0.0015542104,
0.00086992496,
0.0050014444,
-0.016769158,
-0.018753752,
-0.046990935,
-0.018434085,
0.030980984,
-0.0029119595,
0.008351279,
-0.005051392,
-0.008664287,
-0.022363316,
-0.03479034,
-0.049042124,
0.014358341,
-0.044673353,
0.0026855292,
0.0031616986,
0.008018294,
0.022096926,
-0.013492578,
-0.0092170425,
0.0025623245,
0.039052557,
-0.007898419,
0.009117147,
-0.013945439,
0.031407207,
-0.023961646,
0.014691327,
-0.004358782,
-0.018367488,
0.0006418298,
-0.02433459,
-0.025559979,
-0.0112216165,
0.012173955,
0.0070126774,
-0.0042389072,
-0.006693011,
0.028956432,
0.00024266329,
0.010742117,
-0.021817219,
-0.04637824,
0.019899221,
-0.011834309,
-0.016422851,
0.0077985236,
-0.0037227795,
-0.011641178,
0.0030218447,
0.0051845866,
0.015024312,
-0.03012854,
-0.02087154,
-0.0012928167,
0.0046451497,
-0.0036528525,
0.018673835,
-0.01599663,
-0.006912782,
-0.013152933,
0.0019379765,
0.018913584,
-0.009689882,
-0.03241948,
0.0115879,
0.0106622,
0.01876707,
0.009876354,
-0.00949675,
-0.02248319,
-0.025599936,
-0.04105047,
0.004425379,
-0.01969943,
0.024561021,
0.03665506,
-0.0028220534,
-0.018394127,
0.00648656,
-0.044620074,
-0.027491294,
0.009902993,
0.015850117,
0.020831581,
0.028743321,
-0.0032183062,
-0.0068328655,
-0.006116946,
-0.0025173714,
-0.025533339,
-0.027411377,
0.010908609,
0.0025589946,
0.018434085,
-0.0040158066,
-0.026239268,
-0.0031234054,
0.03569606,
-0.005870537,
-0.0044054003,
0.015090909,
0.0050946805,
0.03132729,
-0.010702158,
0.010535666,
-0.0006002066,
0.0025023872,
0.03734767,
-0.011634518,
-0.013958758,
-0.009103827,
-0.01089529,
-0.008204767,
0.0044153896,
-0.0054609645,
-0.0048349514,
-0.020205569,
-0.016196422,
-0.0010056166,
-0.004432039,
0.008191447,
-0.0006052014,
0.0023825122,
0.011674477,
-0.007905079,
0.028103989,
0.01020934,
-0.021044692,
0.026106074,
-0.010182701,
0.009636604,
-0.00065223564,
-0.019100057,
-0.017621601,
-0.0012878219,
-0.01253358,
-0.025653213,
-0.034151006,
-0.0106888395,
-0.018953543,
-0.03796036,
0.020432,
0.014891118,
-0.024521062,
-0.013092996,
-0.0019529607,
-0.014012036,
-0.011747734,
-0.0021910456,
0.008444516,
-0.04014475,
0.0034796998,
-0.011634518,
-0.020218888,
-0.01992586,
0.008391238,
-0.0077985236,
-0.026971838,
0.020138972,
0.20000449,
-0.008644307,
0.029276097,
0.02227008,
0.0067362995,
0.0066463933,
0.019552916,
-0.013512557,
-0.00533443,
0.0026272568,
0.0017781433,
-0.00278376,
-0.0059837517,
-0.0021144587,
0.012546899,
-0.016569365,
-0.0026472358,
-0.021950413,
-0.025626576,
-0.00044037352,
0.0050680414,
-0.03409773,
0.012853246,
-0.007212469,
0.01554377,
0.016729198,
-0.03036829,
0.0068861432,
0.041396774,
0.017914627,
-0.028929792,
0.0050946805,
0.0005144628,
-0.008337961,
-0.007818503,
-0.0094834315,
0.001146303,
-0.0273581,
-0.008937335,
-0.022696301,
-0.018833667,
0.0002245572,
-0.018593919,
0.013998716,
-0.022363316,
0.02408152,
0.008258044,
-0.01878039,
0.017261976,
-0.02412148,
-0.039718527,
0.005933804,
0.0017997874,
0.028583487,
-0.0014118591,
-0.015983311,
-0.000113735405,
0.0076386905,
-0.008178127,
0.00093319226,
-0.006246811,
0.017235337,
-0.025373505,
0.030661318,
0.0088773975,
0.033032175,
-0.014731285,
0.010262618,
-0.0041390117,
-0.015010993,
-0.010142743,
-0.02204365,
-0.025200354,
-0.0029036347,
0.000049583643,
-0.035349756,
0.050880205,
-0.0057872906,
0.010788735,
0.025919603,
0.0015400586,
0.012606836,
-0.009170424,
0.008604349,
-0.013958758,
-0.035349756,
0.056900587,
0.005144628,
-0.024774132,
-0.000055306835,
0.00626346,
-0.003569606,
-0.009316938,
-0.009949611,
0.013239509,
0.016342936,
0.012127337,
-0.012646794,
-0.013132954,
-0.007472198,
-0.01900682,
0.0671299,
0.02321576,
0.01276001,
-0.013326085,
-0.003383134,
0.016169783,
0.0046484796,
-0.0037194495,
-0.006473241,
-0.009396855,
-0.007285726,
0.0019646152,
0.005540881,
-0.004891559,
0.043687716,
0.00086992496,
-0.03172687,
0.02573313,
0.0012495286,
0.013299447,
-0.02229672,
-0.010782075,
0.024933964,
-0.018673835,
-0.015810158,
0.008650967,
0.0020828252,
-0.021390997,
-0.022310037,
-0.022216802,
-0.0040024873,
0.014678007,
-0.0051812567,
-0.007159191,
-0.012253871,
0.010076146,
0.010848672,
-0.017754795,
0.007139212,
-0.0019779347,
-0.006123606,
0.000023894321,
-0.0006139423,
0.0048749098,
-0.023029286,
0.027144989,
0.00037523318,
-0.005870537,
-0.02669213,
-0.021817219,
-0.026545616,
-0.0044819866,
-0.00029781403,
0.018580599,
-0.007938378,
-0.013619113,
-0.021430956,
-0.020352082,
0.021937095,
-0.027238226,
0.038333308,
0.008677606,
0.005061382,
-0.014318382,
-0.015330659,
-0.16718543,
0.009390195,
0.014398299,
-0.027038435,
0.029302737,
-0.0075920727,
0.013998716,
-0.020764984,
0.012939822,
0.003799366,
0.0347637,
0.02131108,
-0.011314852,
0.008298002,
-0.0078851,
0.0030951016,
-0.02757121,
0.035216562,
0.027118351,
-0.002112794,
0.020218888,
-0.026106074,
0.023815133,
-0.008957313,
-0.005347749,
0.00087824964,
-0.0031084209,
-0.0070393165,
-0.0077186073,
-0.033351842,
-0.0155171305,
-0.029089626,
0.027025115,
-0.010635561,
0.0078051835,
-0.0035995748,
0.0051679374,
-0.020338763,
-0.0027887546,
0.035296477,
0.0007329846,
0.022336677,
0.019446362,
-0.015343978,
0.00811819,
0.03614892,
-0.024987243,
-0.008497793,
0.02156415,
0.010548986,
0.010548986,
-0.0071858303,
0.00032008244,
-0.0013086336,
0.019965818,
0.0019179973,
0.009656584,
0.0023841772,
-0.004242237,
-0.025266951,
-0.013918799,
-0.0001836624,
0.018633876,
-0.015610367,
0.012133997,
-0.030341651,
-0.0100894645,
0.0058572176,
-0.037134558,
0.0056008184,
-0.013532536,
0.0028853207,
0.014731285,
-0.019672792,
0.031913344,
-0.0039059215,
0.012407045,
0.015783519,
0.015583728,
-0.017261976,
-0.029036349,
0.0014668017,
-0.014997673,
-0.010129423,
-0.0017040541,
-0.0008532757,
-0.0058971755,
0.0089439945,
-0.0112948725,
-0.009230362,
0.010708818,
-0.019512959,
0.024161438,
-0.004658469,
0.009243681,
0.019233251,
-0.005873867,
-0.0005373556,
-0.025546659,
0.0043454627,
0.0017664888,
-0.012999759,
0.0034047782,
0.012573537,
0.049841292,
-0.0033215317,
-0.0034896894,
0.006676362,
0.02850357,
-0.013299447,
0.012074059,
-0.010635561,
-0.0016374569,
0.02805071,
-0.005727353,
0.040277943,
-0.011554602,
0.012613496,
-0.006703001,
-0.012373746,
0.08210094,
-0.0014401629,
-0.00672631,
0.027810961,
0.018900264,
0.0038359945,
-0.13511226,
-0.005817259,
0.009403515,
0.021977052,
0.0017132111,
0.025573296,
-0.009723181,
0.024494424,
-0.02994207,
0.029036349,
-0.016769158,
-0.03108754,
-0.013292787,
-0.0011296538,
0.023788495,
-0.022110246,
-0.012393725,
-0.0011512978,
-0.0033331863,
0.044353686,
0.003759408,
-0.003779387,
0.0027504615,
-0.011348151,
-0.0054443153,
0.0004907376,
-0.0413435,
0.014185188,
0.019499639,
0.026012838,
0.024694216,
-0.021857178,
0.010315895,
0.013825564,
-0.02853021,
0.004012477,
0.010955228,
-0.03947878,
0.036362033,
-0.019792667,
-0.010795395,
-0.0073390035,
0.0043987404,
0.017927947,
0.0002688859,
-0.028077349,
-0.01971275,
0.0016074881,
0.017927947,
-0.023668619,
-0.02316248,
-0.0050081043,
-0.009876354,
-0.0028686712,
0.0035163283,
-0.006639734,
0.010262618,
0.004595202,
-0.01626302,
0.02506716,
0.017301934,
-0.0030484835,
-0.025080478,
0.0009523389,
0.014717965,
-0.016129825,
-0.03313873,
-0.038546417,
0.019219931,
-0.0320199,
-0.0012212248,
-0.000202705,
0.006979379,
-0.020471957,
-0.032126453,
0.018873626,
-0.013479259,
-0.00602038,
0.0051779267,
-0.01719538,
-0.011234935,
-0.020045735,
0.024267994,
0.0017331903,
0.0006551492,
0.01321287,
0.019539597,
-0.016689241,
0.006912782,
-0.008424536,
-0.0009689882,
0.027944155,
-0.021484233,
-0.010302575,
-0.02204365,
-0.0060004015,
0.015423895,
0.00019718993,
0.03060804,
0.027890878,
-0.004005817,
-0.020978095,
-0.058712028,
0.024747493,
-0.0031067561,
-0.011814331,
0.00066680374,
-0.00625347,
-0.0065265186,
-0.011767712,
-0.00139188,
0.014651368,
-0.02805071,
-0.0071258927,
-0.02505384,
0.0069860388,
-0.0315404,
-0.015264062,
0.033485036,
-0.006426623,
0.023149163,
0.022816176,
-0.000109573084,
-0.016129825,
0.003546297,
0.024521062,
-0.009430153,
-0.0053643985,
-0.005704044,
0.032179732,
0.0019862594,
-0.023668619,
0.0077852043,
-0.0315404,
-0.013026399,
0.0018230964,
-0.003729439,
-0.00950341,
0.020112332,
0.028024072,
0.0077785444,
0.047870014,
0.0020595163,
-0.031194095,
0.007119233,
0.021843858,
-0.025333548,
-0.0030434888,
-0.022603065,
0.011521303,
0.007139212,
-0.0002468256,
0.019299848,
-0.00079958176,
0.0005723191,
-0.005750662,
-0.017954586,
-0.014225147,
0.004528605,
0.0069727194,
-0.00050322455,
-0.009257001,
0.031007623,
-0.007518816,
0.024201397,
0.0044653374,
-0.0038826126,
-0.0051845866,
-0.023548745,
0.017981224,
-0.0171421,
-0.02390837,
-0.026625533,
0.0129931,
0.0320199,
0.011807671,
0.0051845866,
-0.004085734,
-0.018487362,
0.018700473,
-0.019193292,
0.02850357,
0.011028484,
0.021031372,
-0.020019097,
0.006399984,
0.035909172,
-0.027784321,
-0.018287571,
0.032712508,
-0.015237423,
0.009017251,
-0.017315254,
0.016023269,
-0.012007462,
0.016342936,
0.009536709,
0.03481698,
0.0006255968,
-0.0035229882,
-0.0015458858,
0.020565193,
0.015676964,
-0.01043577,
-0.0009531714,
-0.020352082,
-0.0035429671,
0.007219129,
-0.021684024,
-0.030794512,
-0.0029119595,
0.006106957,
0.014384979,
0.019899221,
-0.011767712,
0.0023758525,
-0.017275294,
-0.0123004895,
0.0076187113,
-0.015290701,
-0.021843858,
0.041130386,
0.014491535,
-0.0047150766,
0.015144187,
-0.005257843,
0.008870738,
-0.018154377,
0.01968611,
-0.03364487,
0.023681939,
0.008604349,
0.023455508,
0.025147075,
-0.012926502,
-0.002222679,
0.0111417,
-0.038333308,
-0.014531493,
0.0100894645,
-0.016609324,
0.07213801,
0.028343737,
-0.013279468,
0.002527361,
-0.024920646,
0.000037070666,
0.017648239,
0.01600995,
-0.01644949,
-0.014544813,
0.019379765,
-0.027917515,
0.015969992,
-0.00020020762,
-0.009536709,
0.00858437,
0.0005365231,
-0.00010946903,
-0.033751424,
-0.006749619,
0.019259889,
-0.008904036,
0.029116264,
0.023562064,
-0.0075720935,
-0.0010963553,
0.022056969,
-0.0012187274,
-0.0064166333,
0.006623084,
0.007851802,
-0.0074322396,
-0.051199872,
-0.02922282,
-0.009010592,
0.016129825,
0.029329374,
-0.0033798043,
0.011434727,
-0.0062568,
-0.011035144,
0.019632833,
-0.023362273,
-0.0054676244,
-0.01019602,
-0.018607238,
-0.0009964595,
-0.0222834,
-0.008218085
] |
Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infection. Programmed death-1 (PD-1) and interleukin-10 (IL-10) are both upregulated during HIV infection. Blocking interactions between PD-1 and programmed death ligand-1 (PD-L1) and between IL-10 and IL-10 receptor (IL-10R) results in viral clearance and improves T cell function in animal models of chronic viral infections. Here we show that high amounts of microbial products and | [
-0.015997138,
-0.01666807,
0.008735279,
-0.025732236,
-0.010103455,
0.014957849,
-0.018180957,
-0.0074920803,
-0.026916236,
-0.0136159845,
0.014418473,
0.0035618625,
-0.00569306,
0.0021163975,
-0.024548238,
0.01047181,
0.040124398,
-0.013865939,
-0.011241409,
-0.0045090616,
-0.033362452,
0.0015005538,
0.009103633,
-0.020141132,
-0.006906659,
0.020009577,
0.015418293,
-0.044965636,
-0.017431092,
-0.0017776424,
0.0014923316,
-0.010340255,
-0.013865939,
0.0051701274,
0.005873949,
-0.011307186,
0.0136159845,
-0.015378826,
0.020890998,
0.008682657,
0.005265505,
0.013188429,
-0.0040519065,
0.014576338,
0.0033579518,
0.008879989,
0.0071434584,
-0.007524969,
-0.009386478,
0.024456149,
0.014681583,
-0.0071960804,
0.0057062157,
0.0018631534,
-0.0023663528,
-0.005443105,
0.0027215525,
0.0046603503,
0.012741141,
-0.027600324,
-0.020798909,
-0.02118042,
-0.011511098,
0.019746466,
0.00560426,
0.028415967,
-0.0006063882,
0.023377394,
0.019496512,
0.014168517,
0.036546092,
0.039729733,
-0.025850637,
0.010432344,
0.017957313,
-0.015142027,
-0.01557616,
-0.0017135091,
-0.009570655,
0.011280876,
0.028205479,
-0.039598178,
-0.0037887956,
0.011517676,
0.017457401,
-0.020693665,
0.0068803476,
0.021272508,
0.027810812,
-0.019128155,
0.0100903,
0.014089583,
0.014286917,
0.050490964,
-0.0154709155,
0.03352032,
0.009649589,
0.047359943,
-0.01265563,
-0.012267541,
-0.010465233,
-0.012070208,
-0.010583633,
-0.015786648,
-0.017667891,
0.0054595494,
0.005482571,
-0.0044465726,
0.011701853,
-0.00036999956,
-0.03625667,
0.027205657,
-0.0031162186,
-0.061725795,
0.012530652,
0.014050117,
0.0055746604,
-0.006377148,
-0.013195007,
-0.01643127,
0.02946841,
0.0030438632,
0.038098443,
-0.014971005,
0.008031458,
0.01150452,
-0.0032724408,
-0.021377753,
-0.00035396626,
0.0044991947,
0.012662208,
0.023285307,
-0.0025291527,
0.00032724405,
-0.0074789245,
0.012991096,
-0.023811528,
-0.0016197759,
0.0035684402,
-0.014655272,
0.010662565,
0.034204405,
0.014523717,
-0.001230043,
0.021903975,
0.013412073,
0.01424745,
0.007840702,
-0.0029517743,
0.0073671024,
-0.036914445,
-0.021469843,
-0.0069790143,
-0.027231969,
-0.008840523,
-0.0057391045,
-0.010629676,
0.033020407,
-0.0023729305,
-0.021732952,
0.0044268393,
-0.02663997,
0.011761053,
0.014760517,
0.0019996422,
0.026600502,
0.0033530183,
0.03791427,
-0.0074263024,
-0.006035104,
0.0063179485,
0.021272508,
-0.033020407,
0.015484071,
-0.015615626,
0.026337393,
-0.018667711,
0.011964964,
-0.0013147318,
-0.02168033,
0.0020522643,
0.028126545,
0.006847459,
0.014155362,
-0.012063631,
-0.004147284,
0.027547702,
-0.02442984,
-0.0041111065,
-0.00548586,
-0.006209415,
0.003247774,
-0.009103633,
-0.04504457,
-0.6327289,
-0.01937811,
0.03338876,
-0.009307545,
0.002631108,
0.019483356,
0.017431092,
-0.0068277256,
-0.029836765,
0.023456328,
0.021088332,
0.024456149,
-0.0017135091,
-0.027074102,
-0.004436706,
-0.03578307,
-0.0026837303,
-0.0043281727,
-0.0016781536,
-0.008814212,
-0.021811886,
-0.015983982,
0.01802309,
0.0055943937,
-0.0044399947,
-0.0067060366,
0.039150886,
-0.0067422143,
-0.0058443486,
0.026797835,
-0.00766968,
0.017115358,
-0.001958531,
-0.012800341,
0.04893861,
0.0042525283,
0.005153683,
0.027547702,
0.015260426,
0.04720208,
-0.0011733097,
0.010577055,
0.00042303285,
0.008551101,
-0.0059627485,
0.024666637,
-0.0036967068,
0.003913773,
0.017141668,
-0.005429949,
0.01835198,
0.0077354577,
-0.032467872,
0.00852479,
0.009590389,
-0.0043906616,
0.0028695522,
-0.02324584,
0.006834303,
-0.009097056,
0.016497048,
0.016247092,
-0.0059134155,
-0.003135952,
-0.010202122,
-0.01120852,
0.011254565,
0.015497226,
0.0028070635,
-0.0039367955,
0.013852784,
0.015878737,
0.009268078,
0.004147284,
0.027547702,
0.02554806,
0.007761769,
-0.0021229754,
-0.009360167,
0.025442814,
-0.0048215054,
-0.00007795685,
-0.022311796,
0.006153504,
0.0020769308,
-0.008130124,
-0.01389225,
0.02170664,
0.010248166,
0.017759979,
0.016233936,
-0.008373502,
-0.012024164,
-0.037388045,
-0.013865939,
0.016536513,
-0.031468052,
-0.00474915,
-0.012162297,
-0.006035104,
0.0046570613,
-0.013431807,
0.009419367,
0.014550027,
0.03699338,
0.0007539769,
-0.04604439,
0.0008390768,
0.05259585,
-0.008163013,
-0.01094541,
-0.011188787,
-0.013708073,
-0.010899365,
0.012616163,
-0.011274298,
0.026008504,
0.010932254,
0.0013632429,
-0.01814149,
0.014444783,
-0.01041261,
0.007077681,
-0.00035047182,
0.012563541,
0.013879095,
0.013260785,
-0.008879989,
0.0070382142,
-0.0034566182,
-0.013425229,
0.004074929,
0.033257205,
-0.006209415,
0.015326205,
0.0048872833,
0.038072135,
-0.0025390193,
0.0009981766,
-0.01401065,
-0.030599786,
-0.022548595,
0.0043281727,
-0.0037394622,
0.011030921,
-0.02044371,
0.0016839092,
0.005209594,
0.002793908,
-0.014273761,
0.02106202,
-0.01885189,
0.0017924424,
0.0065185702,
0.008057768,
-0.02274593,
0.009840344,
-0.02011482,
0.006354126,
-0.0114124315,
0.0045583947,
0.011557142,
0.007472347,
-0.0010540877,
-0.019154467,
0.0076762578,
0.028442279,
0.023087973,
-0.010629676,
-0.030020943,
-0.0039269286,
-0.010761232,
-0.020759443,
-0.003972973,
0.010050833,
0.0023696418,
-0.004124262,
-0.014523717,
-0.0042492393,
0.0035980402,
0.008794479,
-0.0034533294,
0.009070745,
-0.008886567,
0.036204048,
-0.00092911004,
0.010932254,
0.010517854,
0.0048412387,
0.052201185,
-0.009452255,
0.021469843,
-0.016062915,
0.015444605,
0.008334035,
-0.020127976,
-0.0032559962,
0.013326562,
0.0008082435,
0.014997316,
-0.01604976,
-0.038361557,
0.0098995445,
-0.016378649,
0.0038512845,
-0.0009282878,
-0.0036440846,
-0.039414,
0.010938832,
0.009044434,
-0.0007112214,
-0.0035026625,
0.00013104151,
-0.001337754,
0.00834719,
0.026968857,
-0.009471989,
0.004147284,
-0.011984698,
-0.017931001,
-0.009037856,
0.011537408,
0.026205836,
-0.042702883,
-0.0059956373,
0.005952882,
0.012017586,
0.008393235,
-0.00766968,
-0.025771704,
-0.01174132,
-0.015181494,
0.02168033,
0.020009577,
0.011734742,
-0.0021969753,
0.0032987518,
-0.0035848848,
0.045597102,
0.00802488,
-0.0056799045,
0.018720334,
-0.006462659,
0.0076236357,
-0.0116492305,
-0.0038578622,
0.007498658,
0.0039992845,
-0.020956775,
0.034125473,
-0.013971183,
0.005370749,
-0.019457044,
-0.01345154,
-0.007886746,
-0.0002809941,
0.011807097,
-0.010846743,
0.043465905,
0.017102202,
0.006525148,
-0.016510203,
0.010070566,
-0.015497226,
0.0015655092,
-0.010498121,
-0.008807634,
-0.024653483,
-0.011662386,
0.0074789245,
-0.009281234,
-0.013839629,
0.013523895,
-0.047412567,
0.0022726196,
0.019049222,
0.019628067,
0.006847459,
-0.00045098836,
0.030441921,
-0.0032346186,
-0.022824863,
0.034441203,
0.02215393,
-0.011938653,
-0.022759086,
-0.030731343,
0.0005249883,
-0.0064889705,
-0.0036605292,
-0.013747539,
0.02657419,
0.015049938,
0.018444067,
-0.008281413,
-0.02339055,
0.039177198,
-0.012767452,
0.017588958,
0.013629139,
-0.0036605292,
0.0018976867,
-0.018299356,
-0.026179526,
0.023430018,
0.0029303967,
-0.005775282,
-0.040755864,
-0.0148920715,
0.000031090243,
0.009471989,
-0.0028300856,
-0.008708968,
-0.022456508,
0.007991991,
0.0029188856,
-0.004463017,
0.012991096,
0.009965322,
-0.004124262,
-0.019207088,
-0.01787838,
0.00085264345,
-0.013280518,
0.035177916,
0.030810276,
-0.010044255,
0.01572087,
-0.020298999,
0.022456508,
-0.015431449,
-0.02521917,
0.03483587,
-0.026732057,
-0.0070579476,
-0.012168875,
-0.002913952,
-0.00037287734,
0.024127262,
0.017207447,
0.018299356,
-0.025416505,
-0.022995884,
0.011945231,
0.007327636,
-0.007689413,
0.025863793,
0.028758012,
0.025377037,
-0.011274298,
0.017523179,
0.015431449,
0.0048247944,
-0.020838376,
0.0030109743,
0.03946662,
0.009511456,
0.016168159,
-0.017562646,
-0.030231431,
0.017983623,
-0.0028432412,
0.022666996,
0.009235189,
0.0032576406,
0.032310005,
0.011655808,
-0.007978835,
0.0006339326,
0.009774567,
-0.009314123,
0.02640317,
0.0029978186,
-0.030047255,
0.017588958,
-0.0019437311,
-0.01666807,
-0.011083542,
0.012076786,
-0.0049037277,
0.013918562,
-0.012760874,
-0.024614016,
0.0020851532,
-0.008814212,
-0.028310724,
0.013642295,
-0.008827368,
-0.016878558,
-0.009919277,
0.00031819963,
-0.01156372,
-0.025034994,
-0.015655093,
0.005778571,
-0.026232148,
-0.0055713714,
0.012872696,
-0.015181494,
-0.0034368848,
0.01569456,
-0.013208162,
0.008511635,
0.028337033,
-0.006380437,
-0.0116426535,
0.0081695905,
-0.03188903,
0.015589315,
-0.0071960804,
-0.008156435,
-0.010629676,
-0.008906301,
-0.00305373,
-0.013241052,
-0.0111822095,
0.0026985302,
0.012162297,
-0.020654198,
0.02657419,
0.028784322,
0.024416683,
-0.0038315512,
-0.005893682,
-0.025745392,
-0.026626814,
-0.024048328,
-0.010129766,
-0.010215277,
-0.040282264,
0.01460265,
0.018154645,
-0.004893861,
-0.028468588,
0.03259943,
0.0016140203,
-0.0039335066,
0.008432701,
0.040124398,
0.043229107,
0.017246913,
-0.005179994,
0.014115895,
-0.028863255,
-0.03723018,
-0.016168159,
0.022206552,
0.011728164,
0.0011848209,
-0.029494721,
0.011478209,
-0.029836765,
-0.016220782,
-0.0034829292,
-0.020772599,
0.016181314,
0.022364419,
-0.026297925,
-0.02339055,
0.0139580285,
0.014971005,
0.015983982,
0.0076039024,
-0.029521033,
-0.006291637,
-0.0012464875,
0.00584106,
-0.011550564,
0.031731162,
-0.034204405,
-0.00784728,
0.025284948,
0.0036407958,
0.021404063,
0.006554748,
-0.01309634,
-0.021548776,
0.0059989262,
-0.018786112,
-0.03502005,
-0.0013509096,
-0.00006701103,
0.03352032,
0.037124936,
0.027442457,
-0.003262574,
0.013550206,
0.013629139,
0.023206374,
0.0064264815,
-0.01076781,
0.018930823,
-0.017944157,
-0.0073342137,
0.0036934179,
-0.018233579,
0.002344975,
-0.03238894,
0.015707714,
-0.0026541303,
-0.013241052,
-0.020298999,
-0.00498595,
-0.012938474,
-0.01987802,
0.021035708,
-0.016878558,
0.0045616836,
-0.027153036,
0.0024699527,
0.014471094,
0.0073868358,
0.010734921,
0.013852784,
0.025034994,
-0.006926392,
0.032730985,
0.009748256,
-0.009590389,
0.007886746,
-0.016247092,
-0.0032263962,
0.00660737,
0.03459907,
-0.004028884,
0.006212704,
0.0069987476,
-0.0074789245,
0.000026182608,
0.0025406638,
-0.008866834,
-0.04265026,
-0.032415252,
-0.01652336,
-0.01545776,
-0.015681405,
-0.021825042,
-0.042913374,
-0.009478567,
-0.009656167,
-0.021377753,
0.013319985,
-0.01873349,
-0.015707714,
0.04399213,
0.0051898607,
0.011215098,
-0.011116432,
0.02265384,
0.015852425,
0.006041682,
-0.010004789,
-0.018601933,
-0.0021706643,
0.0023383973,
0.027731879,
0.03575676,
-0.010037677,
-0.014628961,
0.019772777,
0.0011675542,
0.017562646,
-0.030047255,
0.030731343,
0.0046833726,
-0.012912163,
-0.021640863,
-0.024219349,
-0.03338876,
0.0045090616,
-0.014300073,
0.01704958,
-0.009222033,
-0.0067685256,
-0.011465053,
-0.002348264,
-0.0077157244,
0.011123009,
0.0045583947,
-0.030626098,
-0.0026952412,
-0.043097552,
0.01059021,
0.0048971497,
-0.0037263068,
0.018180957,
0.0026064415,
0.005183283,
0.0032346186,
-0.01654967,
0.01778629,
0.0201806,
-0.0069921697,
0.038098443,
-0.005439816,
-0.0033908405,
-0.0033711072,
-0.016181314,
0.013313407,
-0.020193754,
0.0065942146,
-0.0048478167,
-0.036598712,
-0.018509844,
0.01654967,
0.0284949,
0.0054759937,
0.02250913,
-0.027389836,
-0.006893503,
-0.024232505,
-0.01728638,
0.037203867,
-0.042281907,
-0.001036821,
-0.0092088785,
0.01345154,
0.025258638,
0.015786648,
0.0065185702,
0.0016493759,
0.033651873,
-0.043202795,
0.014457939,
0.0035092405,
0.002976441,
-0.0006146104,
-0.0024107527,
-0.025771704,
-0.009195723,
0.0061370595,
-0.016483892,
-0.040597998,
-0.008906301,
-0.014707894,
0.0073671024,
0.013083185,
0.0015770204,
0.014957849,
0.0040979506,
0.010050833,
0.0052819494,
-0.0121030975,
0.030020943,
-0.026942547,
-0.017759979,
0.029047433,
-0.011537408,
-0.008084079,
-0.00840639,
0.03188903,
0.01138612,
-0.015405138,
-0.029547343,
-0.012668786,
-0.00037061624,
-0.00296493,
-0.006834303,
-0.022838019,
0.014589494,
-0.014352694,
0.010695455,
0.019128155,
-0.01041261,
-0.016220782,
0.014181673,
0.002793908,
0.0045583947,
0.0023926639,
-0.021785574,
0.014379006,
-0.025271794,
-0.009149678,
-0.0032000851,
-0.01643127,
0.026613658,
-0.0023235972,
-0.002177242,
-0.022759086,
-0.005087905,
-0.05725291,
0.0029994631,
0.020062199,
0.016089225,
0.019259712,
0.012833229,
-0.029310543,
0.0065942146,
0.0005455438,
0.034678005,
0.0009471989,
-0.027310902,
0.0010655988,
0.008110391,
0.033204585,
-0.00066435477,
-0.013142385,
-0.012925318,
0.035519958,
0.0076762578,
0.010919099,
0.014589494,
-0.0079393685,
0.0116492305,
-0.019075533,
0.024179883,
0.007584169,
-0.0002433775,
0.0099719,
-0.023114285,
-0.018246735,
0.021206731,
-0.0021410643,
0.023430018,
-0.002961641,
-0.0025077749,
0.009656167,
-0.001289243,
-0.007998569,
-0.045676038,
0.027153036,
-0.019207088,
0.022232864,
-0.0039104843,
-0.011905764,
0.011017765,
-0.007242125,
-0.0010853321,
-0.00047359944,
0.0041703065,
-0.012556964,
-0.020456865,
0.029889388,
0.0039400845,
-0.019009756,
0.0050780387,
0.0118728755,
-0.013813318,
-0.009149678,
-0.0043413285,
0.010452077,
-0.044492036,
0.005614127,
0.013865939,
-0.000016611439,
-0.0008814212,
0.004923461,
-0.011228254,
-0.022614373,
0.010261321,
-0.0036999958,
0.0055647935,
-0.0027708856,
0.010748076,
-0.001516176,
-0.0021838197,
-0.009195723,
0.00008001241,
-0.01764158,
-0.0014076428,
0.19438626,
-0.017352158,
-0.008728701,
-0.0012497763,
-0.011162476,
0.02519286,
-0.0072815917,
-0.009656167,
0.014326383,
-0.0013196651,
0.024877127,
-0.0070579476,
-0.006676437,
-0.000065726315,
-0.01728638,
-0.008873412,
-0.035414714,
-0.018601933,
-0.010511276,
-0.020733131,
0.0016518425,
0.008149858,
-0.0015054871,
0.008472168,
0.025008682,
-0.0027741746,
-0.025613837,
0.017562646,
0.012142564,
-0.011313764,
-0.021101486,
0.014155362,
-0.006775103,
0.009774567,
0.025521748,
0.0048774164,
-0.03141543,
-0.015668249,
0.005814749,
-0.03170485,
-0.017141668,
0.008912878,
-0.02324584,
-0.009347011,
-0.0014956205,
0.026442636,
-0.005771993,
-0.008965501,
0.005637149,
-0.004035462,
-0.02312744,
-0.028889567,
0.0284949,
0.0022463086,
0.0019634643,
0.008419545,
0.024022017,
0.02044371,
-0.020522643,
0.025876949,
-0.0043840837,
0.012451719,
-0.019628067,
0.0121030975,
-0.018391445,
0.020049043,
-0.027810812,
0.0147736715,
0.004298573,
-0.036361914,
0.01811518,
-0.006327815,
-0.001482465,
-0.019075533,
-0.012221497,
-0.009781145,
0.02189082,
0.013260785,
0.030468231,
0.014905227,
-0.003548707,
0.005699638,
-0.014563183,
0.009425945,
0.0033497293,
-0.03791427,
0.024403527,
-0.00090279896,
-0.048833366,
0.020141132,
-0.0026097302,
-0.028047612,
-0.018891355,
-0.0022726196,
0.014628961,
-0.017299535,
-0.0022051975,
-0.0073671024,
0.0093799,
-0.03630929,
-0.016483892,
0.08698443,
0.0072684363,
0.0051175053,
-0.0068211476,
-0.0052424828,
-0.007636791,
-0.0033809738,
0.0077683465,
-0.023877306,
0.013293673,
-0.018457223,
0.012412252,
-0.009767989,
-0.0046471944,
0.033178274,
0.007235547,
-0.006775103,
0.010557321,
0.002002931,
-0.003548707,
-0.023679972,
0.008386657,
0.018365134,
-0.011419009,
0.010406032,
-0.034888495,
0.008005146,
0.0047359946,
-0.025955882,
0.014905227,
0.0009414434,
-0.010702032,
0.01345154,
0.010984876,
0.006406748,
0.022916952,
-0.022864329,
-0.0126885185,
0.0134975845,
-0.01448425,
0.015655093,
-0.004035462,
-0.016641758,
0.008590568,
-0.019075533,
0.022693306,
0.010359988,
-0.020496331,
-0.005818038,
-0.010544166,
-0.028810633,
-0.012451719,
-0.011451898,
0.011070387,
-0.013760695,
-0.012024164,
-0.017378468,
-0.00578186,
-0.0016756869,
-0.027652945,
0.024298282,
0.01581296,
-0.016299715,
-0.019601755,
-0.005212883,
-0.16418114,
0.0032954628,
0.0096758995,
-0.01678647,
0.019588599,
0.012833229,
-0.017089047,
0.008130124,
-0.0062850593,
0.01811518,
0.033836048,
-0.005719371,
-0.025679614,
-0.0032592851,
0.00038397734,
0.0068540364,
0.0013813317,
0.0292053,
0.018957134,
0.0050714607,
0.025284948,
-0.011024343,
0.0030109743,
-0.034914803,
-0.0024469304,
0.008090657,
0.0070842584,
0.0051175053,
0.0013681762,
-0.0037953735,
-0.010359988,
0.01460265,
0.039545555,
-0.006163371,
0.015142027,
-0.018562468,
0.00790648,
-0.015891893,
0.0041439952,
0.03188903,
0.040966354,
0.012833229,
-0.0028366633,
0.0043314616,
-0.021548776,
0.032467872,
0.0025982193,
-0.011925497,
0.020733131,
0.004229506,
0.033073027,
-0.008301146,
0.0133791845,
0.009268078,
0.012346474,
-0.0061929706,
0.01156372,
-0.0017759979,
-0.0018417756,
0.01312923,
-0.0069198143,
-0.008755012,
0.020719975,
0.003080041,
0.009570655,
-0.028310724,
-0.0032444852,
0.03502005,
-0.0033415072,
0.017496869,
-0.023916772,
-0.005640438,
0.011076965,
-0.006117326,
0.004870839,
0.031099698,
-0.017365314,
0.011590031,
-0.0076170578,
0.013721229,
-0.008998389,
0.001460265,
-0.018865045,
-0.008893145,
-0.032809917,
-0.013668606,
0.0054792827,
0.016918024,
0.00005442077,
-0.019628067,
-0.005725949,
-0.015668249,
0.013425229,
-0.022443352,
0.000051234663,
0.037572224,
-0.0021459975,
0.007985413,
-0.00834719,
0.017720513,
0.019549133,
-0.017457401,
-0.015049938,
-0.0093799,
0.017667891,
-0.005933149,
-0.039992843,
-0.011004609,
0.03436227,
0.0012399097,
-0.024587706,
0.020075355,
-0.008893145,
0.01985171,
-0.0101429215,
0.013787006,
0.006893503,
0.005656882,
-0.009320701,
-0.03188903,
0.06309397,
-0.0032675073,
-0.035625204,
0.026074281,
-0.020627888,
-0.039045643,
-0.14439522,
-0.019299177,
0.019891176,
-0.0023679973,
-0.013905406,
0.020838376,
-0.0031162186,
0.00090608787,
-0.02058842,
0.002456797,
-0.005640438,
-0.009412789,
-0.014260606,
-0.018891355,
0.015142027,
0.00014152484,
0.0042130616,
-0.0069132363,
-0.011715009,
0.023574729,
-0.00039631064,
-0.0051734163,
0.026863614,
0.0073934137,
0.005084616,
-0.0018302646,
-0.022693306,
0.02215393,
0.0014438205,
0.013655451,
0.013181851,
0.0034664848,
0.02923161,
-0.01064941,
-0.010274477,
0.009754833,
-0.0030076853,
-0.0123398965,
0.019115001,
-0.004377506,
0.0037032845,
0.023587884,
0.005295105,
0.0046110167,
0.019707,
-0.01707589,
-0.009781145,
0.014142206,
0.031310186,
-0.027574012,
-0.0365724,
-0.041597817,
-0.05893682,
-0.019180778,
-0.004860972,
-0.016352337,
0.014905227,
0.018154645,
-0.0063376813,
-0.017917845,
-0.01156372,
-0.0058805267,
-0.021048864,
0.014760517,
0.028205479,
-0.028679078,
-0.0055187494,
-0.026758369,
0.034178093,
-0.0292053,
-0.013918562,
-0.037572224,
-0.03415178,
-0.014681583,
-0.008689234,
0.02300904,
0.007189503,
-0.021035708,
0.010267899,
-0.0018615089,
-0.019101845,
-0.015760338,
0.018707179,
0.0038414178,
0.052727405,
0.0003403996,
0.015641937,
-0.00191742,
-0.0011798876,
0.005153683,
-0.008919456,
0.054516558,
-0.002775819,
-0.015523538,
-0.00089951005,
0.013438384,
-0.016720692,
-0.024535082,
0.019483356,
0.02011482,
-0.026508413,
0.004634039,
-0.046544302,
0.005522038,
-0.018878201,
0.018957134,
0.021640863,
-0.014221139,
-0.006436348,
-0.022390729,
0.022719618,
0.022298642,
-0.010162655,
0.009537767,
-0.009478567,
0.0060844375,
-0.019101845,
-0.01076781,
0.028705388,
0.0052885273,
0.0051635494,
0.024166727,
-0.0005270438,
0.011234831,
0.006377148,
0.007130303,
0.01937811,
0.0016403315,
-0.009662745,
0.019785933,
-0.00030936077,
-0.0032461295,
0.021496153,
-0.017562646,
-0.014063273,
-0.0030948408,
-0.009781145,
-0.018917667,
0.008412968,
0.035335783,
0.011971542,
0.025561215,
0.0038447066,
-0.03946662,
0.0049103056,
-0.008801056,
0.01849669,
0.0034467515,
-0.023258995,
0.011497942,
-0.0072092363,
-0.024587706,
0.055463757,
0.016707536,
-0.017181136,
-0.020614732,
-0.024127262,
0.008491902,
-0.00007055686,
-0.024495617,
-0.0189966,
-0.0065317256,
-0.00011850264,
0.019364955,
0.004515639,
0.009123367,
0.006176526,
-0.017759979,
-0.02592957,
0.007814391,
-0.001267043,
0.011846564,
-0.020312155,
-0.0063146595,
0.0034138628,
0.0075710136,
0.01669438,
-0.01265563,
-0.03112601,
0.0024781749,
-0.020522643,
0.015365671,
0.007176347,
0.0041571506,
-0.015497226,
0.0017661313,
0.03425703,
0.0020802198,
-0.0043084393,
0.029178988,
-0.0048543946,
0.010359988,
-0.011247987,
0.011688697,
0.01448425,
0.015523538,
0.008097235,
0.019917488,
0.000377194,
0.022088151,
-0.0035322625,
0.028152857,
0.007406569,
-0.014102739,
-0.0047919056,
0.004094662,
0.0027922634,
0.02008851,
-0.029573655,
-0.036677647,
-0.014707894,
0.0027741746,
0.014576338,
0.003778929,
0.0101429215,
-0.00021377753,
-0.008064346,
0.009228611,
-0.007584169,
0.019443888,
-0.028363345,
0.030626098,
0.009281234,
0.027100412,
-0.009169412,
-0.011570298,
0.0080511905,
-0.004693239,
0.018694023,
-0.0145368725,
0.025758548,
-0.000049204806,
0.02448246,
-0.010149499,
-0.034967426,
-0.010813854,
-0.024087794,
-0.011708431,
0.0199438,
0.017260069,
-0.0009545989,
0.07635476,
0.00076384353,
-0.032467872,
-0.0029155966,
-0.021101486,
0.0011798876,
0.017523179,
0.019154467,
-0.012609585,
-0.029363167,
0.036072493,
0.0036210625,
0.032257386,
-0.04893861,
-0.01064941,
0.01156372,
-0.0074460357,
-0.0009767988,
-0.0076565244,
0.0027067524,
0.012721407,
-0.0022643975,
0.0007325992,
0.015549849,
-0.04428155,
-0.021167265,
0.019101845,
0.007998569,
-0.0032823074,
-0.053227317,
0.012971363,
-0.005206305,
-0.03088921,
-0.026390014,
0.021351442,
-0.030231431,
-0.03967711,
-0.011366387,
0.0039992845,
0.013576518,
-0.0003537607,
0.017931001,
-0.019891176,
-0.030599786,
-0.0071631917,
-0.028073924,
-0.01837829,
-0.026679436,
-0.014181673
] |
Exonic splicing enhancers (ESEs) facilitate exon definition by assisting in the recruitment of splicing factors to the adjacent intron. Here we demonstrate that suboptimal 5' and 3' splice sites are activated independently by ESEs when they are located on different exons. However, when they are situated within a single exon, the same weak 5' and 3' splice sites are activated simultaneously by a single ESE. These findings demonstrate that a single ESE promotes the recognition of both exon/intron junctions within the same step during exon definition. Our results suggest that ESEs recruit a | [
-0.043186728,
-0.012654684,
0.0012161469,
-0.021471748,
-0.03186305,
0.019296197,
-0.010364274,
-0.0140532525,
-0.01724226,
-0.0045369035,
-0.0014880908,
0.0020657605,
0.013114117,
0.0028072724,
-0.009269741,
0.0050267405,
0.012999259,
-0.009972405,
0.008094133,
0.010593991,
-0.019512402,
0.0012203696,
-0.013708678,
-0.014715377,
0.009100833,
0.01595855,
-0.0032329238,
-0.0138911,
-0.011445293,
-0.02448509,
0.018647585,
0.0042632706,
-0.01783682,
-0.0012127687,
-0.01541804,
0.0060739783,
-0.013715434,
-0.018066538,
0.016526084,
-0.003911939,
0.0415652,
0.00778334,
-0.01837733,
0.010161583,
0.011222334,
-0.002381621,
-0.009134614,
-0.022187924,
-0.028998347,
0.03670061,
-0.0056077885,
-0.0015818354,
-0.024931012,
-0.0051415986,
-0.032835964,
0.00756038,
-0.012870888,
0.019688066,
-0.0072293174,
-0.012485774,
-0.007648213,
-0.0007330663,
-0.027971378,
0.023458121,
-0.010398055,
0.019228633,
0.013120874,
-0.005675352,
0.0073982268,
-0.0012930006,
0.03183602,
-0.00060934026,
-0.024701294,
0.0024694537,
0.016485546,
-0.03240356,
0.002565732,
-0.0036450624,
-0.00090282015,
0.0067124553,
0.015823422,
-0.040078796,
-0.028998347,
0.026579566,
0.0036518187,
-0.018971892,
0.017444951,
0.0069658193,
-0.0031484691,
0.008675181,
0.01763413,
0.026241748,
0.01428297,
0.012424967,
-0.030430697,
-0.0020454915,
0.016863903,
0.00960756,
0.008904898,
-0.009931866,
-0.011965534,
-0.0008382123,
-0.03359268,
-0.0039355867,
-0.03999772,
0.008465733,
-0.012816837,
-0.0256607,
0.025849877,
0.00033929653,
0.003163671,
0.013877587,
-0.007067165,
-0.020769086,
0.0346737,
-0.017107133,
-0.0010168339,
-0.003383253,
-0.025012087,
0.0032295457,
0.027106563,
0.027363304,
0.008330606,
-0.04321375,
0.017553054,
0.011979047,
-0.0092359595,
0.008810309,
-0.010749388,
-0.014985632,
0.023579737,
0.0121209305,
0.016607162,
0.008904898,
-0.03610605,
-0.017161183,
-0.023336507,
-0.024701294,
-0.01403974,
-0.038511317,
0.017958436,
0.009013,
-0.0019019186,
-0.013769485,
0.026201209,
0.012641171,
0.02133662,
-0.014080279,
0.008661669,
0.013060066,
0.00886436,
0.0037396518,
-0.0069725756,
-0.0088778725,
0.019552939,
0.02610662,
-0.0042092195,
0.022160899,
-0.0004163614,
-0.045294713,
-0.015890986,
-0.021174468,
-0.0031940746,
-0.006418553,
0.0074455217,
0.024903985,
-0.0061145164,
-0.0068982556,
0.005840883,
0.0023664192,
-0.013472205,
0.014891043,
-0.046970297,
0.01022239,
-0.002873147,
0.006381393,
-0.0048781005,
0.026822794,
-0.010472376,
-0.015607218,
-0.010681824,
0.009344062,
0.03186305,
-0.0014315062,
-0.030187469,
0.002509992,
0.0089657055,
0.00057640293,
0.001182365,
-0.018174639,
0.008573836,
-0.012884401,
-0.0011350705,
0.016039627,
-0.62482923,
-0.00970215,
0.012762786,
-0.027498432,
-0.0048713437,
0.027349792,
0.00854681,
0.020079937,
-0.02394458,
0.027511945,
-0.0389167,
0.02832271,
0.007830635,
0.0006714144,
-0.031079309,
-0.026930897,
-0.0049152602,
-0.021890644,
0.036538456,
-0.0025539084,
-0.0004716792,
-0.007344176,
-0.0051551117,
0.015404527,
0.020728547,
0.0069185244,
0.020363703,
-0.030160442,
-0.011566908,
-0.006563815,
-0.012323622,
0.023714865,
-0.026809283,
0.012451992,
0.05024038,
0.025133703,
-0.00090282015,
0.022201438,
0.003472775,
0.046132505,
-0.004726082,
-0.0043071867,
0.010235903,
0.0060739783,
0.012087149,
0.011242602,
0.012749273,
0.006111138,
-0.0033950766,
-0.010154827,
0.030646902,
-0.028484862,
-0.01066831,
0.0060739783,
-0.008600861,
0.013519499,
-0.008567079,
-0.010749388,
0.01621529,
0.0131006045,
-0.0055165775,
0.018782713,
-0.038997777,
-0.01335059,
-0.009587292,
0.018120589,
-0.007729289,
0.0020387352,
0.017012544,
0.002347839,
0.024795884,
0.023512173,
-0.017863847,
0.0009585602,
-0.0038747792,
0.025106676,
0.0003483754,
0.016053138,
-0.005979389,
0.011283141,
-0.0127154915,
0.005675352,
-0.025241803,
-0.015215348,
0.018634073,
-0.005324021,
-0.037592452,
0.026079595,
-0.0036416843,
0.01014807,
0.0059185815,
-0.01053994,
-0.0034626403,
-0.02994424,
-0.03772758,
0.0082833115,
0.013357347,
0.010195364,
0.021431211,
-0.023295969,
-0.005384828,
0.00039123613,
0.004614602,
-0.014593762,
0.013364103,
0.02053937,
-0.0063949055,
-0.00014188381,
0.030592851,
-0.02532288,
0.015634244,
-0.0018005731,
0.005962498,
-0.006415175,
-0.013573551,
-0.028836194,
-0.011783112,
0.010121045,
-0.028160557,
-0.038997777,
0.003726139,
0.0043916414,
0.0018799604,
-0.026633617,
0.015877474,
0.023485148,
-0.005347668,
-0.02344461,
0.00024090687,
-0.0020049533,
0.0031484691,
-0.008972461,
0.0059185815,
-0.021012316,
0.017823309,
0.0072022923,
0.011627715,
0.020282628,
0.0105737215,
-0.042321913,
-0.022431154,
-0.004202463,
0.005638192,
0.0026079593,
-0.016431496,
-0.00687123,
-0.027552484,
-0.0039018046,
0.017512515,
-0.0016865593,
-0.007965762,
-0.0035133131,
-0.025701238,
0.017107133,
0.001163785,
-0.017688181,
-0.030484749,
-0.03305217,
-0.030025315,
-0.024512116,
0.012972234,
0.009019756,
-0.0088778725,
-0.0016570002,
-0.025647186,
-0.016174754,
0.020458292,
-0.0025995139,
-0.0031163765,
-0.02049883,
0.0097697135,
-0.0097697135,
-0.0044862307,
0.006546924,
0.004547038,
0.0029423998,
-0.0016502438,
-0.0004492987,
0.0029542234,
-0.01443161,
-0.0014686662,
0.009350819,
-0.0073576886,
-0.016580136,
0.031079309,
0.005874665,
0.010019699,
-0.013661384,
0.011573665,
-0.0061787018,
0.016377445,
-0.0015353855,
-0.0103913,
0.033754833,
0.013972176,
-0.0025505302,
0.01772872,
0.015742347,
-0.026363362,
0.019079993,
0.036970865,
-0.01359382,
0.014458635,
-0.030619876,
0.0115263695,
-0.015512629,
0.013526256,
-0.017026056,
0.0020336679,
0.009067051,
-0.012195251,
-0.01718821,
-0.0016468656,
0.005938851,
0.010411569,
0.006087491,
-0.0017102065,
0.019634016,
0.0031434018,
-0.019512402,
-0.00553009,
-0.03132254,
0.012093905,
0.012276327,
-0.010546696,
0.029673984,
0.01921512,
0.007533354,
0.012195251,
-0.018120589,
0.014296482,
0.019052967,
-0.009154883,
0.026052568,
0.006979332,
0.0048781005,
0.01808005,
-0.024917498,
0.036889788,
-0.004344347,
0.00057006883,
0.011485832,
0.00034457495,
-0.0070468956,
0.014674839,
-0.0159045,
0.018215178,
0.0027430868,
-0.005709134,
0.010891271,
0.0046855435,
0.002091097,
0.00476662,
0.013262757,
0.00014610654,
-0.016836878,
0.012992502,
0.014228919,
0.028484862,
0.026957922,
0.0066077313,
-0.0111682825,
0.022377104,
-0.004195707,
-0.012100661,
0.0028849707,
-0.0077360454,
-0.0058645303,
0.016026113,
-0.028971322,
-0.020012373,
0.0055165775,
-0.016485546,
-0.0030961072,
0.008175209,
0.015526142,
0.01620178,
0.03029557,
0.0105129145,
-0.006671917,
-0.012553338,
-0.021755517,
0.046321683,
0.01970158,
-0.025512058,
-0.0015058264,
-0.024647243,
-0.0049152602,
0.00094420294,
0.017931411,
0.012857375,
0.02532288,
-0.0067698844,
-0.008188723,
-0.010593991,
-0.0033427149,
0.03245761,
-0.0062834257,
0.04688922,
-0.029836137,
0.014228919,
-0.011938509,
-0.044456925,
-0.0027312632,
0.05788859,
0.012107418,
0.0047159474,
-0.013276271,
0.005979389,
-0.012033097,
-0.0069083897,
-0.015255887,
-0.0068847425,
0.0005109506,
-0.0067192116,
-0.024390502,
-0.0065874625,
-0.0014703553,
0.05729403,
0.011688523,
-0.002856256,
-0.01837733,
0.030214494,
0.01783682,
0.014377559,
0.022282513,
0.006266535,
0.019174583,
0.021458237,
-0.012668197,
-0.018120589,
-0.025890416,
0.009958892,
-0.013533012,
-0.02472832,
-0.00824953,
0.008094133,
-0.00008440186,
0.0004902592,
0.03934911,
0.005259835,
-0.04094361,
-0.018931353,
-0.012485774,
0.010114288,
0.015688295,
0.007182023,
0.020823138,
0.016593648,
-0.0001845334,
-0.012674953,
0.017553054,
0.007877929,
-0.010012942,
-0.00876977,
0.014296482,
0.031241462,
0.00891841,
-0.0008120314,
-0.016769314,
-0.0055841412,
-0.0034761531,
0.0022042661,
0.007911711,
0.017971948,
0.0013200261,
0.0207826,
0.0017684803,
-0.0014475526,
-0.008634643,
-0.0074455217,
0.024444552,
0.006161811,
0.001290467,
0.028592965,
-0.020363703,
-0.010323736,
-0.022052797,
0.0009670057,
-0.014918068,
-0.012370916,
-0.0017068284,
-0.009330549,
-0.045537945,
-0.0077900966,
-0.01837733,
0.0008479246,
0.014809966,
0.021093393,
-0.019715093,
-0.009208934,
-0.0020404242,
-0.013039798,
-0.016417982,
0.0062057273,
-0.028160557,
-0.041862477,
-0.018147614,
0.022228463,
-0.0026316068,
0.0034170349,
-0.002344461,
0.012560095,
0.0061955927,
-0.018593535,
0.00021725957,
-0.0052328096,
-0.028214607,
0.0014771117,
0.008350875,
0.008600861,
-0.003415346,
-0.02260682,
-0.007073921,
0.017526029,
-0.011310166,
0.0108710015,
-0.0034018331,
0.025687724,
0.022160899,
0.025106676,
0.030187469,
0.0113777295,
0.0020049533,
-0.009695393,
-0.04886208,
-0.018228691,
-0.02457968,
-0.0066448916,
0.008438708,
-0.0026805904,
0.016323393,
-0.00021103105,
-0.012377673,
0.007763071,
-0.011634472,
0.02053937,
0.019836707,
0.016445009,
0.036538456,
0.015107247,
0.014337021,
-0.012310109,
0.0011933441,
-0.015945038,
-0.015282912,
0.02236359,
-0.019431325,
-0.023674326,
0.015363989,
-0.013864075,
-0.032646786,
-0.0068036662,
0.0068644737,
-0.027214665,
0.04651086,
0.010729118,
-0.01645852,
0.004472718,
-0.013972176,
-0.009499459,
-0.0012034787,
-0.017985461,
-0.0002485078,
0.004996337,
0.005742916,
-0.026863333,
-0.035322312,
0.019931296,
-0.039646387,
-0.013445179,
0.020823138,
-0.01007375,
0.0166477,
-0.008148184,
-0.0068644737,
-0.011627715,
-0.016485546,
-0.013472205,
-0.035403386,
0.0020978535,
-0.008276555,
0.046645988,
0.04267324,
0.029187525,
-0.00036146588,
0.00057302474,
0.014607275,
0.02266087,
0.0011333814,
-0.0024035792,
0.018026,
-0.0015759236,
0.021215007,
0.02580934,
-0.0015345409,
0.022850048,
-0.018971892,
0.016539598,
0.045105536,
-0.022187924,
-0.023133816,
0.041754376,
-0.043781288,
-0.016309882,
0.027917327,
-0.0034829096,
-0.0020640716,
-0.026295798,
-0.004949042,
-0.0029339544,
0.008803552,
0.01443161,
0.0030994855,
0.024903985,
0.01571532,
0.048726954,
-0.0002738442,
-0.01236416,
-0.012749273,
-0.014215406,
-0.010100775,
-0.0032126547,
0.027025485,
0.008337363,
0.020025885,
-0.00043705277,
-0.0051415986,
0.005513199,
0.024606705,
-0.027647072,
0.013945151,
-0.0006802822,
-0.030565824,
0.0037970808,
-0.02349866,
0.0134586925,
-0.018444894,
-0.0007630477,
-0.0058071013,
-0.004303809,
0.011202064,
-0.027998405,
-0.014377559,
0.000009454961,
0.0028140286,
0.011499344,
-0.011580421,
0.014255944,
0.031457666,
0.0014163044,
-0.023322994,
-0.02230954,
0.0054692826,
0.008040082,
0.018539483,
-0.0030403673,
-0.016593648,
-0.0065063857,
-0.008269799,
-0.001390968,
-0.01837733,
-0.025471522,
0.01990427,
-0.019917784,
0.011870945,
-0.0031011745,
0.0019204987,
0.0030234763,
0.015066708,
-0.0072630993,
0.023309482,
-0.0032447474,
-0.0047193253,
-0.020106962,
0.043186728,
-0.0018664476,
0.026079595,
0.004786889,
-0.0065536806,
-0.029673984,
-0.018269228,
-0.0047395946,
-0.00046618964,
0.011397999,
0.034619648,
-0.02448509,
-0.00036167703,
0.0077360454,
0.024241861,
-0.021714978,
-0.018539483,
0.0093237925,
0.033241346,
-0.019242147,
-0.0048308056,
0.01625583,
-0.0009450475,
-0.0009425138,
0.009877815,
0.0079860315,
-0.0038680227,
-0.012431724,
0.005729403,
0.03275489,
0.0069658193,
-0.012573607,
-0.016228804,
-0.0049524205,
-0.0058037234,
-0.0021451479,
-0.031106334,
0.02241764,
-0.029538857,
0.010316979,
-0.0032126547,
0.031646844,
0.051348425,
0.027160613,
0.014485661,
-0.0013191815,
0.024985062,
-0.017796284,
0.013181681,
0.006141542,
0.0027734905,
-0.0150937345,
0.011120988,
-0.020458292,
-0.029025372,
-0.000477591,
-0.026566053,
-0.0035538515,
0.00015222949,
-0.0072630993,
0.01620178,
0.01990427,
-0.0042261104,
0.025147215,
-0.010938565,
0.027971378,
-0.0067698844,
-0.04221381,
0.020377217,
-0.022025771,
-0.0059422287,
0.026512003,
0.0074455217,
-0.0063036946,
0.007296881,
0.0019357004,
0.00073602225,
-0.010208878,
-0.0143505335,
-0.028782142,
-0.008884628,
-0.009972405,
-0.007999544,
0.007823878,
-0.02970101,
-0.017444951,
-0.00008725221,
0.012708735,
-0.0008124537,
-0.018390844,
-0.004229489,
0.0150937345,
0.017080108,
-0.021269057,
0.012539825,
0.0054287445,
-0.019917784,
-0.048808027,
0.01655311,
-0.0039963936,
0.045159586,
0.021782542,
-0.022160899,
-0.004965933,
-0.008310337,
-0.036538456,
-0.0029069288,
0.013803267,
0.022647357,
0.019377274,
0.014945094,
-0.0032379911,
0.014364046,
-0.0072766123,
-0.004442314,
-0.02024209,
-0.03083608,
0.004090983,
-0.002418781,
0.001491469,
0.028214607,
-0.03299812,
-0.00041066072,
0.042186785,
0.00009152772,
-0.008985974,
0.0291605,
-0.021904157,
0.015647756,
0.0026147158,
0.012303352,
0.026322823,
-0.0045909546,
0.03029557,
-0.047159474,
-0.0073239068,
0.024944523,
-0.00064058846,
-0.03297109,
0.009188665,
-0.0017499003,
0.004327456,
-0.0028309196,
-0.01349923,
-0.010641285,
-0.0017803039,
-0.020890702,
0.0049929586,
0.029565882,
0.0066212444,
0.012276327,
0.027606534,
-0.0015505872,
-0.015607218,
-0.011519614,
-0.000031142652,
0.015985575,
0.003493044,
0.00019466795,
-0.019769143,
-0.005347668,
-0.0128641315,
-0.016863903,
-0.005982767,
0.005925338,
0.006671917,
-0.02649849,
-0.005840883,
-0.0031856291,
-0.029079422,
-0.016985519,
0.02634985,
-0.019917784,
-0.018971892,
0.011039911,
-0.0060672215,
-0.0026045812,
0.016985519,
-0.031484693,
-0.016309882,
-0.024944523,
0.002183997,
0.009844033,
-0.030214494,
0.040295,
0.19815086,
-0.0053172642,
-0.018026,
0.025944468,
0.022566281,
-0.029619932,
0.0064455783,
-0.009330549,
-0.008256286,
-0.0013073579,
0.009290011,
-0.007344176,
-0.023633787,
0.0008800174,
0.040295,
-0.01856651,
-0.021052854,
0.0058138575,
-0.030511774,
0.018661099,
0.011195308,
0.0044828528,
-0.011776356,
-0.011762843,
0.015620731,
0.0047159474,
-0.030673927,
0.0042261104,
-0.011830406,
0.0236473,
-0.01497212,
0.015999088,
0.0059726327,
-0.000859326,
-0.008526541,
0.0014686662,
0.014864017,
0.0044625835,
0.006905012,
0.0071955356,
-0.017458465,
0.018904328,
-0.0070131137,
0.003942343,
0.005905069,
-0.019201608,
-0.005851018,
-0.007459034,
-0.010681824,
-0.0030961072,
-0.042646218,
-0.0013225598,
0.002236359,
0.021890644,
-0.013093848,
0.0071617537,
-0.00072884356,
0.005242944,
0.017053083,
0.018607046,
0.0003903916,
0.022079822,
-0.03083608,
-0.0009450475,
-0.018444894,
0.04688922,
0.015336963,
-0.0138911,
0.033754833,
-0.01106018,
0.026268773,
-0.010992616,
-0.0029305762,
-0.002508303,
-0.012742517,
-0.017120646,
0.035889845,
-0.0017955058,
0.035430413,
0.032106277,
0.008627887,
0.009222447,
-0.0416733,
0.01189797,
0.006452335,
-0.04407857,
0.028214607,
-0.015999088,
-0.015945038,
-0.0071955356,
0.017607104,
-0.01699903,
-0.0013115807,
-0.0250256,
0.009229204,
-0.0105129145,
-0.014120816,
0.013999202,
-0.028511887,
-0.015039683,
-0.026133645,
0.07253641,
-0.00534429,
0.0092359595,
0.012641171,
0.010985861,
0.0055334684,
-0.007959005,
0.009992674,
0.013864075,
0.011918239,
-0.013066823,
-0.0029964508,
-0.001979617,
-0.0042430013,
0.0023292592,
0.029565882,
-0.05496984,
0.052564573,
-0.01964753,
-0.01945835,
-0.014742402,
-0.007688751,
0.038159985,
0.0138167795,
0.013546525,
-0.03388996,
-0.00411463,
-0.027674098,
-0.016890928,
-0.0033427149,
0.0085805915,
0.017431438,
0.0038477536,
0.0034406823,
-0.025552597,
-0.020566395,
-0.0077157766,
-0.004601089,
0.0121412,
0.017431438,
-0.015728833,
0.007404983,
0.034322366,
-0.0019357004,
-0.005597654,
0.021052854,
0.010654798,
-0.010019699,
0.011668254,
-0.013168168,
0.006817179,
0.016877417,
-0.0018816495,
0.0334035,
-0.03724112,
-0.027079538,
-0.044565026,
0.00062369753,
0.008276555,
-0.03143064,
0.015634244,
0.0037903246,
-0.021998746,
-0.012492531,
0.014026227,
-0.17047676,
0.0034575732,
-0.006509764,
-0.046186555,
0.015796397,
0.020255603,
0.019485375,
0.0021502152,
-0.028052455,
-0.014309995,
0.016512573,
0.0052260533,
-0.05551035,
-0.024174297,
-0.007830635,
0.02374189,
-0.006746237,
0.0021130552,
0.0334035,
-0.0014087035,
0.01403974,
-0.039565314,
0.01886379,
-0.012411455,
0.008837334,
-0.0026400522,
-0.0016654456,
-0.023417585,
0.004452449,
-0.002798827,
-0.007675238,
0.0111682825,
0.0046652746,
-0.033025146,
-0.0006671917,
0.0047193253,
0.0026518758,
-0.002597825,
-0.0046483837,
0.016917955,
0.037511375,
-0.005986145,
-0.014566737,
-0.00094420294,
0.017998975,
0.011776356,
-0.0034085894,
-0.017147671,
0.008033326,
0.016823364,
-0.012870888,
-0.014404585,
0.020674497,
0.023931067,
0.0028511889,
-0.014526199,
-0.0025302612,
0.019498888,
0.011019642,
-0.0038342408,
0.0014129262,
-0.012931695,
0.02994424,
-0.0027768686,
-0.015526142,
-0.02133662,
0.0017346984,
0.023525685,
-0.02994424,
0.0046247365,
-0.01916107,
-0.002580934,
-0.012100661,
-0.027998405,
0.032295454,
-0.0001678536,
-0.00225325,
0.032727864,
-0.017404413,
-0.017431438,
-0.018904328,
0.025701238,
0.0016544665,
-0.029430754,
-0.022350077,
0.018688124,
0.011046668,
0.024133759,
-0.005128086,
-0.0005738693,
0.022336565,
-0.023377046,
0.0015320072,
-0.013708678,
0.031214437,
0.02699846,
0.017661156,
0.0015793019,
-0.007384714,
0.0018816495,
0.028538914,
-0.020890702,
-0.017499002,
0.014147842,
0.008519785,
-0.0024846557,
0.01556668,
-0.0017938167,
0.037322197,
-0.008296824,
-0.0069083897,
-0.0033224458,
0.008999487,
0.0016156173,
-0.0069725756,
0.027038999,
-0.007418496,
0.0049355295,
0.0063611236,
-0.027268715,
0.049726896,
-0.019417811,
0.00009786182,
-0.0052665914,
0.00795225,
-0.028160557,
-0.13653275,
-0.0105129145,
0.029511832,
0.01566127,
0.002873147,
0.011350704,
0.009519728,
0.04791619,
-0.019836707,
0.023809453,
-0.02517424,
0.0010109221,
0.017255774,
-0.025295855,
0.008560323,
0.009749444,
0.012039854,
-0.019012429,
-0.03388996,
0.046618965,
-0.0009450475,
0.0011435159,
0.003547095,
-0.028295685,
0.0187692,
0.025890416,
-0.025471522,
0.01014807,
0.019971834,
-0.012911426,
-0.0003840575,
-0.01189797,
0.008648155,
-0.0007740268,
-0.021742003,
-0.025782313,
-0.0032835966,
-0.014836992,
0.022012258,
0.012931695,
-0.0068847425,
-0.008215748,
0.01403974,
0.00992511,
-0.0054422575,
-0.016080163,
-0.019012429,
-0.0024306048,
-0.0010066994,
-0.03418724,
-0.036241177,
-0.018985404,
-0.026133645,
-0.019323222,
0.006715833,
0.023282457,
0.0122695705,
0.005742916,
0.013715434,
0.0159045,
0.01832328,
-0.007600918,
-0.011566908,
0.0018833386,
0.010208878,
-0.017080108,
-0.019552939,
-0.019444838,
0.01243848,
-0.012783055,
-0.008587348,
0.008154941,
-0.009134614,
0.028755117,
-0.043484006,
0.001945835,
-0.012377673,
-0.031214437,
-0.004256514,
-0.03172792,
0.0013453625,
-0.022552768,
0.0056584612,
-0.022890586,
0.014742402,
0.0066820513,
0.008053595,
-0.009229204,
0.009627829,
-0.036052,
0.0056989994,
0.02807948,
-0.0020100204,
-0.00931028,
-0.031295512,
-0.00038067932,
-0.0003114265,
-0.01994481,
0.01418838,
0.011188552,
0.0010455485,
-0.009350819,
-0.04640276,
0.007290125,
-0.01862056,
-0.0063847713,
0.0021755516,
-0.01305331,
0.013080335,
-0.0054118535,
-0.011769599,
-0.000032224725,
0.00065959076,
-0.008742745,
-0.011810138,
-0.0129519645,
-0.017161183,
-0.010154827,
0.0033764967,
-0.010060238,
0.009073807,
0.0207826,
0.0014711999,
-0.024998575,
-0.0040031504,
0.01718821,
-0.019201608,
-0.0023039228,
-0.017742231,
0.0003050924,
-0.02137716,
-0.013674896,
-0.0014407962,
-0.03299812,
-0.02999829,
0.009648099,
-0.023877017,
-0.0027464652,
0.023566224,
0.02448509,
0.031295512,
0.022539256,
-0.0010675067,
-0.035700668,
0.012384429,
0.0138167795,
-0.0082833115,
0.011857432,
-0.0066313786,
0.001018523,
-0.0003737118,
-0.0121412,
0.013147899,
0.0061010034,
0.014769428,
0.006398284,
-0.009776469,
0.00225325,
0.0035572296,
0.013316808,
0.008296824,
-0.018836765,
0.007648213,
0.026012031,
0.01305331,
0.034295343,
0.014553225,
0.0065705716,
-0.02157985,
-0.019525914,
0.0026518758,
-0.011026398,
-0.016080163,
0.01512076,
-0.016485546,
0.014242431,
0.022106849,
0.003976125,
-0.01649906,
0.010566965,
-0.015836935,
0.010816951,
0.034889903,
0.0041585467,
0.013080335,
0.014985632,
0.010458863,
0.006242887,
-0.01197229,
0.027809225,
-0.021174468,
0.0053882063,
-0.00411463,
0.024363477,
-0.0034305477,
0.032592736,
-0.015728833,
0.024255374,
-0.006790153,
0.026430925,
0.015161298,
-0.011046668,
-0.0113777295,
-0.0028089616,
0.0059185815,
0.009242716,
-0.019417811,
0.034349393,
-0.022863561,
-0.021782542,
-0.0003224056,
0.0019340114,
0.008600861,
-0.0026316068,
0.00077993865,
-0.0047395946,
-0.026822794,
0.027998405,
0.0012558405,
-0.009837277,
-0.011756087,
-0.0015438308,
0.0008952192,
0.012722247,
0.007296881,
-0.0057395375,
0.026052568,
-0.010918297,
0.03783568,
-0.031592794,
0.013688409,
-0.010141314,
0.026849821,
-0.0088778725,
-0.010121045,
-0.018269228,
-0.02048532,
-0.012343891,
0.018998917,
-0.0059354724,
0.006857717,
0.091994755,
0.027606534,
-0.004783511,
-0.0030082744,
-0.039241005,
0.020106962,
-0.0075130854,
0.028511887,
-0.0070874337,
-0.036889788,
0.000004536138,
-0.018039512,
0.008871116,
-0.0036079024,
-0.012674953,
0.010121045,
-0.0010987549,
0.024998575,
-0.022741947,
-0.008634643,
0.021147443,
-0.034889903,
0.030133417,
0.016228804,
-0.03837619,
0.018201666,
0.034349393,
-0.00011475275,
-0.0036484406,
-0.023228405,
0.0027920706,
0.004932151,
-0.04783511,
0.009985917,
0.004489609,
0.010985861,
0.005925338,
-0.024444552,
0.043862365,
0.020579908,
0.0032768403,
-0.018728662,
-0.013972176,
-0.011884457,
0.00370587,
-0.0041382774,
-0.00016299746,
0.024012145,
-0.009418382
] |
SecDFyajC of Escherichia coli is required for efficient export of proteins in vivo. However, the functional role of SecDFyajC in protein translocation is unclear. We evaluated the postulated function of SecDFyajC in the maintenance of the proton motive force. As previously reported, inner membrane vesicles (IMVs) lacking SecDFyajC are defective in the generation of a stable proton motive force when energized with succinate. This phenomenon is, however, not observed when NADH is used as an electron donor. Moreover, the proton motive force generated in SecDFyajC | [
-0.0057316185,
-0.021864448,
-0.017934954,
-0.022700792,
-0.040356964,
0.0313563,
-0.022262707,
0.006594514,
0.004510289,
-0.00949849,
0.020563466,
0.018187186,
0.016461393,
0.02843573,
-0.010600341,
-0.022660967,
0.009544953,
-0.005814589,
-0.011874772,
0.021492738,
-0.019355413,
-0.004204957,
-0.013202303,
-0.028833989,
0.02449296,
0.015133861,
0.012598276,
-0.028541932,
-0.013885982,
0.002568774,
0.0076200324,
0.004221551,
-0.026617011,
0.0032723658,
-0.02029796,
-0.019740397,
0.017337564,
-0.010082603,
0.032922786,
-0.01610296,
0.01944834,
0.021466188,
-0.019793497,
0.005565677,
-0.0016112917,
0.010062691,
-0.011742018,
0.0038830303,
0.005522532,
0.01879785,
0.01567815,
0.017802201,
-0.001610462,
-0.0000831263,
-0.01862527,
-0.03143595,
-0.0122000165,
-0.0027944543,
0.0015772737,
-0.043383736,
0.011350396,
0.016607422,
-0.021864448,
0.024984147,
-0.011051701,
-0.0019033486,
0.01485508,
0.013507635,
0.0051309103,
0.014058561,
0.038657725,
0.03390516,
-0.010626892,
-0.0011524635,
0.04903902,
-0.021638768,
-0.030665983,
-0.012923522,
-0.009332548,
0.01635519,
0.0065911952,
-0.04317133,
-0.023072502,
0.008469652,
0.014124937,
0.008111219,
0.009976401,
0.028462281,
-0.005466112,
0.009491852,
0.03273693,
0.04967624,
0.010938861,
0.0011076593,
-0.011323846,
0.01139686,
0.0076864087,
0.02114758,
0.0060203564,
-0.011436686,
-0.03053323,
-0.002256804,
-0.013952359,
-0.013660301,
-0.024824843,
-0.005658604,
0.010547239,
-0.023404384,
0.0067770495,
-0.024386758,
-0.008582492,
0.02591342,
-0.0126912035,
-0.035418548,
0.009664431,
-0.020510366,
0.030798737,
0.005346634,
-0.0109521365,
-0.0015465745,
0.0041352613,
0.023377834,
0.024054876,
-0.01959437,
0.041365888,
-0.011051701,
0.011888047,
-0.004158493,
-0.002928867,
-0.027506458,
0.0006222805,
0.022514937,
0.011569439,
-0.00033063837,
-0.009432113,
0.00816432,
-0.02758611,
-0.016647248,
-0.0055490825,
-0.009896749,
0.01216019,
0.012279669,
-0.026497534,
0.0012412422,
-0.005685155,
-0.005091084,
0.020191757,
0.012770856,
0.0060568633,
0.01982005,
0.007998379,
-0.007055831,
0.0034515825,
-0.025860319,
0.0071089324,
0.032046616,
-0.015651599,
0.030373927,
-0.009305998,
-0.03472823,
-0.0039991895,
-0.000038736962,
-0.0006222805,
-0.031701457,
0.024585888,
0.042029656,
-0.0037436394,
-0.001122594,
0.0064816736,
-0.006514862,
0.015598498,
-0.009385649,
-0.018585443,
0.026895793,
-0.010129067,
-0.005313446,
0.025276205,
-0.0002233987,
-0.0333476,
-0.034914084,
0.0015407666,
0.02976326,
0.024081426,
0.0112176435,
0.004918505,
-0.009452026,
0.01959437,
-0.0054030544,
0.016209163,
-0.021452913,
-0.024811568,
-0.0027562878,
0.000033006796,
0.0038033784,
-0.6227717,
-0.03815326,
0.006385428,
-0.02274062,
-0.011350396,
0.0072682365,
0.0072615985,
0.011503062,
-0.00018149849,
0.0022783764,
-0.021691868,
0.016262263,
-0.019381963,
-0.022979574,
-0.0032790033,
-0.009817097,
0.001278579,
-0.02509035,
0.015545397,
-0.006936353,
-0.02276717,
0.020975001,
-0.0059738928,
0.03817981,
0.008516116,
0.0063256887,
0.034144115,
-0.015266615,
-0.021559115,
0.008111219,
-0.02112103,
0.023789369,
-0.0037602338,
-0.007746148,
0.04056937,
0.021506013,
-0.003597611,
0.010759645,
0.00041215713,
0.035763707,
-0.012226568,
-0.008934288,
0.023338009,
0.005967255,
-0.013965634,
0.02279372,
0.028143672,
0.014058561,
-0.0014237778,
-0.010328197,
0.0022966298,
-0.0048156213,
-0.011124716,
0.013992185,
-0.006050226,
-0.0031147213,
0.003737002,
-0.022607865,
0.017457042,
0.018758023,
0.017735824,
0.011662367,
-0.007122208,
-0.017311014,
-0.006451804,
-0.0037768278,
-0.022103403,
0.0003248304,
0.02151929,
0.011211006,
-0.0035909733,
0.015293166,
-0.008502841,
0.018333213,
0.0013656983,
0.028196774,
-0.008091306,
0.017616346,
-0.0073678014,
-0.00038249508,
-0.002248507,
0.0059207915,
-0.019010255,
-0.0125319,
0.02469209,
0.011967699,
-0.031674907,
0.021652043,
-0.0018419503,
-0.019859875,
0.008907738,
0.007819162,
0.02139981,
-0.0480832,
-0.024400033,
0.013647026,
-0.012604914,
-0.004334391,
0.020629844,
-0.027851615,
-0.014788704,
-0.011861496,
0.021837898,
-0.01959437,
-0.0036739442,
0.017018957,
-0.015532121,
0.01754997,
0.04683532,
-0.010593703,
-0.004643042,
-0.026603736,
-0.0017191536,
-0.020855524,
-0.010872485,
-0.03855152,
0.023563689,
0.007334613,
0.0075536557,
-0.02486467,
-0.0034549013,
-0.013620475,
0.0015797628,
0.007308062,
-0.009929937,
0.045295384,
0.019713847,
-0.027108198,
-0.017603071,
0.016288815,
-0.0016892841,
0.011722106,
0.040861428,
-0.013049637,
0.008390001,
0.021041378,
0.020961726,
0.019182833,
-0.002216978,
-0.014058561,
-0.0335069,
-0.013109376,
-0.005154142,
-0.01527989,
-0.008157683,
-0.026258579,
-0.026829416,
-0.019912977,
0.019979352,
-0.014682501,
-0.016859652,
0.015120586,
-0.023789369,
0.016341915,
0.010049416,
-0.019182833,
-0.025541712,
-0.021784795,
-0.012346045,
-0.023855746,
0.005817908,
0.023882296,
-0.030719085,
0.012292944,
-0.0014022054,
-0.00086538476,
0.01845269,
0.0042646956,
-0.004785752,
-0.028249875,
-0.0011831627,
0.012684566,
0.008409914,
0.0047791144,
-0.0074142646,
0.024599163,
0.0042547393,
0.009465301,
-0.019169558,
-0.011025151,
0.010547239,
-0.030719085,
0.001420459,
0.0030284317,
0.024214178,
0.008383363,
0.020351062,
0.0042547393,
0.007991741,
0.028701236,
-0.0009118484,
-0.01590383,
-0.0008852977,
-0.007932002,
-0.008018292,
0.00095250405,
0.022129955,
0.0037004948,
0.00019477379,
0.01545247,
-0.012273031,
-0.021678593,
0.023815919,
-0.033745855,
0.030427027,
-0.006707354,
-0.0087484345,
-0.019156283,
0.03462203,
0.021705143,
0.010162256,
-0.0026235345,
-0.009332548,
-0.0012636443,
-0.008031567,
0.024346933,
0.0013590606,
-0.00029019013,
-0.00807803,
0.0026235345,
-0.020231584,
-0.016687075,
0.01885095,
0.00632237,
0.010719819,
0.0022186374,
-0.0007430029,
-0.013899257,
-0.017934954,
-0.009392287,
-0.011224281,
0.004749245,
0.0012097133,
0.011662367,
0.022820272,
0.018373039,
0.021253783,
-0.0023878978,
0.039533895,
-0.02429383,
-0.010115792,
0.0141647635,
0.005715024,
0.0005509257,
-0.008894463,
-0.0016743494,
0.023975223,
0.014669226,
-0.005695111,
0.018930603,
-0.0073213377,
0.020762596,
-0.011363672,
-0.015332991,
-0.01754997,
-0.005389779,
-0.012538537,
0.010706544,
0.027692312,
0.011576077,
0.005114316,
0.003308873,
0.018120809,
0.006182979,
-0.0012578364,
0.00773951,
0.018054431,
-0.015864003,
0.011376947,
-0.016979132,
-0.026205476,
0.00762667,
0.0026965488,
-0.022422012,
0.00048537878,
0.005539126,
0.013388158,
0.006285863,
-0.00501807,
-0.013288593,
-0.013992185,
-0.03682573,
0.03010842,
0.003297257,
0.0026235345,
-0.0038100162,
-0.023085777,
-0.0010512392,
-0.010719819,
0.019063355,
-0.0023281588,
0.022076853,
-0.008463015,
0.0051840115,
-0.007832437,
0.0012453907,
-0.0021472827,
-0.028302977,
0.031117344,
0.0114565985,
-0.0058046323,
-0.0036440745,
-0.035338894,
0.0011068296,
0.05392434,
0.0019780223,
0.0020626525,
-0.01842614,
0.028833989,
-0.014616124,
-0.012877058,
-0.016979132,
-0.012983261,
0.0038398856,
-0.005077809,
-0.00028002623,
-0.013135927,
-0.007188584,
0.03733019,
0.00051027,
-0.017218087,
-0.024944322,
0.009332548,
-0.0060933707,
0.029152596,
0.030851837,
-0.002245188,
0.016819827,
0.020258134,
0.032391775,
0.0024476366,
-0.025103625,
0.024745192,
-0.01547902,
-0.0040124645,
-0.016063133,
0.0016809871,
-0.008715246,
-0.0015772737,
0.014523197,
-0.011874772,
-0.019581093,
0.009558229,
0.0035312343,
-0.0018817763,
-0.0056254156,
0.016023308,
0.023510586,
0.0018701603,
-0.0068965275,
0.010753007,
0.028913641,
0.00921307,
0.011529613,
0.010281733,
0.0033022352,
0.027068373,
0.011894684,
-0.0070093675,
-0.047764592,
-0.013109376,
0.015864003,
-0.0040556095,
0.051933043,
0.012525262,
-0.009339185,
0.0022202968,
-0.010892398,
-0.0052371128,
-0.004068885,
-0.009047129,
0.008058118,
-0.007474004,
-0.020005904,
0.02755956,
-0.024585888,
-0.010381298,
-0.027479907,
0.02571429,
0.000052893844,
-0.005466112,
0.004062247,
-0.024771743,
-0.020284684,
-0.011177817,
-0.007978465,
0.018771298,
0.026311679,
-0.0017174942,
0.0056121405,
-0.010547239,
-0.030267723,
-0.02321853,
-0.009969763,
-0.00079361507,
-0.024612438,
-0.03977285,
-0.010806109,
-0.007639945,
0.01273103,
0.007819162,
-0.021439638,
0.0010645145,
0.0015681469,
-0.010766283,
-0.002588687,
-0.028249875,
-0.023576964,
-0.01959437,
0.017815476,
0.009936575,
-0.016209163,
-0.02047054,
-0.00077287236,
0.03762225,
-0.004530202,
0.008396639,
-0.018917328,
0.0036573499,
-0.0045633903,
0.013620475,
0.015797628,
-0.008914376,
0.014894906,
0.020908626,
-0.034860983,
0.011151266,
-0.024506235,
0.012837232,
-0.007235048,
-0.0015722954,
0.0006052715,
0.004400768,
-0.0016859653,
0.011230919,
-0.012498711,
-0.013149202,
-0.019753672,
0.014350618,
0.01675345,
-0.004377536,
0.026630286,
-0.003952726,
0.00086123624,
0.008217421,
-0.017722549,
0.042852726,
0.0066011515,
0.02157239,
0.005426286,
0.025408957,
-0.041976552,
-0.013574012,
0.023510586,
0.0051441854,
0.02321853,
-0.017788926,
-0.02546206,
-0.043250985,
-0.011576077,
0.008456377,
0.0119477855,
-0.00042771414,
-0.025767392,
-0.01944834,
-0.009744083,
-0.013885982,
-0.036931932,
0.011410136,
-0.025010698,
-0.012372596,
-0.014018735,
0.002512354,
-0.00501807,
0.0012877058,
0.008463015,
-0.028356077,
-0.016248988,
-0.01967402,
-0.04975589,
-0.0080050165,
-0.010626892,
0.033958264,
0.04229516,
0.030665983,
0.012857145,
0.0066442965,
0.03090494,
0.010056053,
0.0053731846,
0.0056121405,
0.0065480503,
-0.021426363,
0.018479241,
0.01967402,
-0.012067264,
0.02659046,
0.002256804,
0.008031567,
0.0032176052,
-0.016235713,
-0.008104581,
-0.004125305,
-0.028090572,
-0.007639945,
0.023338009,
-0.0035245968,
-0.007527105,
-0.04274652,
-0.016833102,
0.01732429,
0.012034075,
0.002401173,
0.0028425774,
0.034515824,
-0.0003385206,
0.036560223,
0.0011649091,
0.008031567,
-0.009106868,
-0.01066008,
0.0040722038,
-0.0026185564,
0.030798737,
0.0034051188,
0.014602849,
-0.00040137093,
0.0130562745,
0.005024708,
0.0066210646,
-0.0045833034,
-0.017921679,
0.017337564,
-0.03722399,
-0.023231806,
-0.016580872,
-0.012053988,
-0.06366842,
0.005037983,
0.0027878166,
-0.003084852,
-0.004858766,
0.014509922,
-0.007726235,
0.035710603,
0.014337343,
0.022090128,
-0.0060070814,
0.022913197,
0.039799403,
-0.00910023,
-0.028833989,
-0.001996276,
-0.0040224213,
0.010699905,
0.012717754,
0.028913641,
-0.0021671955,
-0.015067485,
-0.0020311235,
0.002397854,
-0.024771743,
-0.017802201,
0.02973671,
-0.0061962544,
0.024572613,
0.0040722038,
0.023059227,
-0.0229663,
0.015359542,
-0.0091135055,
0.023045952,
-0.0050645336,
0.008290436,
-0.02132016,
0.0070890193,
0.018970428,
0.03048013,
0.0058676903,
0.010102517,
-0.00981046,
-0.029657058,
-0.00700273,
0.008808173,
-0.008058118,
0.023669891,
0.017709274,
0.017881854,
-0.011927873,
0.021877723,
-0.012750942,
-0.022873372,
-0.007135483,
0.030294275,
-0.018465966,
0.0002951684,
0.022621142,
-0.021028103,
-0.0034748144,
-0.029869463,
-0.0015357883,
-0.013096101,
-0.048693866,
-0.0021555796,
0.018532343,
0.0062493556,
0.0045268834,
-0.0057216617,
-0.013003173,
0.0073412503,
-0.0030483447,
-0.008821448,
0.009664431,
-0.029922565,
-0.017948229,
-0.011124716,
0.023656616,
0.02007228,
-0.023444211,
0.0031196997,
-0.0019116458,
0.02219633,
-0.012890333,
0.014762153,
0.0026003027,
-0.012996536,
-0.01595693,
-0.0018436097,
-0.016434843,
-0.0118349455,
0.002440999,
-0.0139125325,
-0.031940416,
-0.010401211,
-0.032418326,
0.045295384,
0.014363893,
0.001684306,
-0.0052935327,
0.0033702713,
0.018067706,
0.0028226643,
-0.001678498,
0.017603071,
-0.015133861,
0.01148315,
0.012870421,
-0.028833989,
-0.016315365,
0.016116235,
-0.024705365,
-0.016063133,
0.0009939894,
-0.0035411909,
-0.023669891,
-0.02134671,
-0.006246037,
-0.009073679,
0.014589574,
-0.039507344,
-0.010129067,
0.000025215324,
0.014589574,
-0.0043874923,
-0.015943656,
-0.02840918,
0.0030798737,
-0.0060070814,
-0.023895571,
-0.018386316,
-0.0016096323,
-0.016979132,
-0.015293166,
0.020178482,
-0.0031628443,
0.020682944,
0.00045177565,
-0.029922565,
0.007865625,
0.014735603,
-0.042003103,
-0.0076864087,
-0.040277313,
0.014337343,
0.013321781,
-0.013321781,
-0.017828751,
0.012146915,
-0.006461761,
0.023072502,
0.012777493,
-0.00688989,
0.02838263,
-0.0015332992,
0.010016227,
0.014563023,
-0.040436618,
-0.017934954,
0.031250097,
0.025873594,
0.0066874414,
0.017311014,
-0.0074142646,
-0.0019680657,
-0.004666274,
0.0009690982,
0.0020676306,
0.0016453096,
-0.0005430434,
-0.031568706,
-0.026683388,
-0.0022534851,
0.012631465,
-0.0059440234,
0.0048554474,
0.01712516,
-0.021758245,
-0.023404384,
-0.0040423344,
-0.023510586,
0.004334391,
-0.013527549,
0.009949851,
0.0029272074,
0.010202082,
0.00062850333,
0.035418548,
-0.0002812708,
-0.03055978,
0.0020825653,
-0.043728895,
-0.016209163,
-0.007998379,
0.009876836,
0.0030964678,
-0.017085334,
-0.0024609119,
-0.0070093675,
-0.012638102,
-0.0013615497,
0.00028936044,
-0.035232693,
0.008496203,
-0.0027579472,
-0.009943212,
-0.013102738,
0.0020095513,
-0.014098387,
-0.006518181,
0.008237335,
-0.006202892,
0.0077129593,
-0.010832659,
-0.01137031,
-0.01488163,
-0.0029637145,
-0.008516116,
0.0036839007,
-0.0035080027,
0.012910246,
0.19870496,
0.007912089,
-0.0021987245,
0.022475112,
-0.005851096,
-0.0027297372,
-0.011602627,
-0.0034183941,
0.0013499338,
-0.005276939,
-0.0017988055,
0.02177152,
-0.005167417,
-0.0011607605,
0.027745413,
-0.001244561,
-0.03231212,
-0.005651966,
-0.031621806,
0.0017191536,
-0.0005081957,
-0.019567817,
0.010175531,
0.0019431746,
0.023112327,
-0.022209605,
-0.01607641,
0.009511765,
0.0123261325,
-0.0006816046,
-0.017642897,
-0.0049516936,
0.010872485,
0.00019249211,
-0.0025355855,
0.01627554,
-0.009657794,
-0.01046095,
0.0046961433,
-0.0061199213,
-0.013162477,
-0.0099830385,
-0.0064252536,
-0.0017257913,
-0.0133085055,
-0.005738256,
-0.013593925,
-0.010394573,
-0.020842249,
-0.010540602,
-0.062128484,
-0.01944834,
0.007858988,
0.015638324,
-0.0014063539,
-0.026019622,
0.0064119785,
0.009677706,
0.0070823818,
0.017682724,
-0.011430048,
0.0030035407,
-0.026298404,
0.03937459,
-0.027665762,
0.032338675,
-0.012080539,
0.0032939382,
0.046622913,
-0.03390516,
0.008170958,
-0.026510809,
-0.009936575,
-0.0109654125,
-0.012034075,
0.0074341777,
0.039507344,
0.013208941,
0.008436464,
0.016607422,
0.014191315,
-0.019939527,
-0.041498642,
-0.008031567,
0.01295671,
-0.028833989,
-0.005001476,
-0.009153332,
-0.014775428,
-0.015412644,
0.012346045,
-0.011303932,
-0.0059805303,
-0.012173466,
-0.010029502,
-0.009379012,
0.023696441,
-0.00481894,
0.018519068,
-0.012790768,
-0.031329747,
0.0751914,
0.00038643618,
-0.006674166,
-0.01545247,
0.008343537,
-0.0036473935,
0.009199795,
-0.005678517,
-0.014682501,
0.01505421,
-0.013700128,
-0.0024277237,
-0.0065845572,
0.0075204675,
-0.00078407343,
0.01400546,
-0.01927576,
0.039560445,
-0.024001773,
-0.013560737,
-0.010381298,
0.0009176563,
0.016381742,
-0.0029720117,
-0.010613617,
-0.012206654,
-0.000053930977,
-0.025077075,
-0.035630953,
0.011064977,
0.013633751,
0.027718863,
-0.0038398856,
0.011137991,
0.017470317,
0.013235492,
0.008947564,
0.00014644334,
0.007294787,
-0.020390887,
0.015757801,
0.01380633,
0.018864226,
0.0076996842,
-0.01182167,
0.021638768,
0.019793497,
-0.016262263,
-0.026709938,
-0.00017755738,
-0.012823957,
-0.0033437207,
-0.014642675,
0.012365958,
-0.035710603,
-0.029550856,
-0.053658832,
-0.0045069703,
-0.005154142,
-0.047153927,
0.010719819,
0.013467809,
0.007912089,
-0.011337121,
0.009186519,
-0.16684419,
0.00575485,
-0.0045169266,
-0.010679993,
0.03884358,
0.02486467,
0.023776093,
0.0073810765,
-0.023311457,
0.0061730226,
0.031993516,
0.017085334,
-0.041020732,
0.0058776466,
-0.009173244,
0.018134084,
-0.022514937,
-0.0153860925,
0.008230696,
0.014523197,
0.03894978,
-0.009916662,
0.01077292,
-0.011303932,
-0.0005646158,
0.032816585,
-0.011038426,
-0.0021871086,
-0.019063355,
-0.0013391477,
0.0033603148,
0.0020543553,
0.052198548,
-0.011230919,
0.015691426,
-0.010626892,
-0.0022949704,
-0.0030649388,
0.02449296,
0.012896971,
0.0051043597,
0.028541932,
0.003929494,
-0.0051640985,
-0.0023430935,
0.016461393,
-0.010593703,
-0.0015781034,
0.012399146,
-0.0047359695,
0.032046616,
-0.00943875,
-0.007175309,
0.019713847,
0.0073478883,
0.011390222,
-0.024054876,
0.013328419,
-0.009166607,
-0.011874772,
-0.029019844,
-0.0018021243,
0.027851615,
-0.022528214,
0.0036009299,
-0.022899922,
-0.018532343,
0.008595768,
-0.023656616,
0.013633751,
-0.0010520689,
0.009339185,
0.00688989,
-0.005970574,
0.00762667,
0.012146915,
-0.00620953,
0.012385871,
-0.027267503,
-0.0033470395,
-0.030214623,
0.02678959,
-0.022700792,
-0.02047054,
-0.029152596,
-0.0065779197,
0.009671069,
-0.013029724,
-0.00094088813,
0.013454534,
0.0035312343,
-0.02798437,
0.016235713,
-0.0035279156,
0.035949558,
0.017045507,
-0.003753596,
0.0004513608,
0.012976623,
-0.0027396937,
0.012717754,
-0.028117122,
-0.03178111,
0.00303341,
0.009232983,
0.014576298,
-0.013965634,
0.002744672,
0.047870796,
-0.0128040435,
0.003192714,
-0.011994249,
0.014709052,
0.036294717,
-0.0040323776,
0.025422232,
0.0029189105,
-0.0063256887,
0.006684122,
0.00025160876,
0.084377915,
-0.020218309,
-0.019488165,
0.0057913573,
0.012910246,
-0.012538537,
-0.12404457,
-0.0020560147,
-0.0010130727,
0.055756334,
0.0013507636,
-0.0078058867,
-0.0006484163,
0.01885095,
0.0029587364,
0.0078058867,
-0.00533004,
-0.013713403,
0.011436686,
0.0046131727,
0.016010033,
0.00034246172,
0.008695333,
-0.007467366,
-0.04893282,
0.020935176,
0.014244416,
0.0151604125,
0.00072308996,
0.012319495,
0.01213364,
0.01709861,
-0.008974114,
0.04473782,
0.023948673,
0.011390222,
0.0077195973,
-0.0078058867,
0.027373705,
-0.00416845,
-0.018134084,
-0.0015490636,
0.0069761793,
-0.029391553,
0.039507344,
-0.024559338,
0.009140056,
-0.00045260537,
0.008721883,
-0.00816432,
-0.01014898,
-0.006514862,
0.009850286,
0.018001331,
-0.0029637145,
-0.007825799,
-0.04354304,
-0.024798293,
-0.02483812,
0.0013175752,
0.025674464,
-0.017204812,
0.00024974192,
0.048322156,
-0.017178262,
-0.007726235,
-0.006962904,
0.005837821,
-0.0034648578,
-0.0025189915,
0.014098387,
0.0094122,
-0.00012186327,
-0.011191092,
0.032020066,
-0.049065575,
0.00037979853,
0.017443767,
-0.023696441,
-0.012286306,
-0.033639655,
-0.001204735,
-0.0052404315,
-0.011748656,
-0.00093176134,
-0.035338894,
-0.024572613,
-0.021466188,
0.0125319,
-0.03308209,
0.029338451,
0.014921457,
0.024652265,
-0.0043642605,
0.042188957,
0.0073412503,
-0.005967255,
0.028913641,
0.025793942,
-0.020483814,
-0.019036805,
0.019992627,
-0.0060635014,
-0.0051740548,
0.03016152,
0.006109965,
-0.032338675,
-0.021452913,
-0.0627126,
0.013175753,
0.011177817,
-0.021851173,
0.022780444,
-0.016766725,
-0.010002952,
0.017483594,
-0.000020911219,
0.023457486,
-0.021306885,
-0.015359542,
0.010766283,
-0.0098436475,
-0.016859652,
-0.0005223008,
0.053366777,
-0.018970428,
0.020550191,
0.008350175,
-0.018505793,
0.005618778,
0.0005534148,
0.040224213,
-0.027506458,
0.01377978,
-0.00012943434,
0.015372817,
-0.009073679,
0.0007305573,
0.0039394503,
-0.03387861,
-0.0153860925,
0.002429383,
-0.029311901,
-0.0041186674,
-0.03642747,
0.031940416,
0.035391998,
0.028621584,
-0.01023527,
-0.03504684,
0.01859872,
-0.001244561,
0.0070292805,
0.00069819874,
-0.04479092,
0.004958331,
-0.0061365156,
-0.016647248,
0.0071288454,
0.005250388,
-0.004181725,
-0.0038199725,
0.0042547393,
0.002837599,
0.0025106943,
-0.0009599714,
0.0016627335,
-0.011303932,
0.0020510366,
0.0051640985,
0.031196997,
0.012963347,
0.0109654125,
0.008555942,
-0.029975668,
-0.0109654125,
0.029842913,
-0.029896015,
-0.017682724,
0.009166607,
0.0053831413,
-0.0036108864,
0.004414043,
0.013162477,
-0.008575855,
-0.00133251,
-0.0025389045,
0.026085999,
0.012538537,
0.0061630663,
0.006531456,
0.012292944,
0.024081426,
0.00413858,
0.013567374,
0.011098165,
-0.0054959813,
-0.0054030544,
-0.00069902843,
0.03048013,
-0.0027994325,
0.010646804,
0.0007081552,
0.026125824,
-0.009936575,
-0.0041651307,
-0.00972417,
0.012664652,
-0.028196774,
-0.0011524635,
0.007792611,
-0.0069761793,
-0.006869977,
0.011297295,
-0.035365447,
-0.045693643,
-0.004915186,
-0.0037469584,
-0.010255183,
0.0035312343,
0.00024849735,
0.006684122,
-0.018253561,
0.004633086,
0.01066008,
-0.0073014246,
0.0036706252,
0.007467366,
0.006883252,
0.03305554,
-0.007958553,
-0.011098165,
0.03855152,
0.03095804,
0.03093149,
0.0026484258,
0.024227453,
-0.022289257,
0.030665983,
0.012206654,
-0.0021954055,
-0.038657725,
0.00014270966,
0.0064650797,
0.0033586554,
-0.0130562745,
-0.016341915,
0.08644887,
0.023045952,
-0.0033238076,
-0.00035511475,
0.008854637,
0.00016345235,
0.00024331168,
0.03690538,
0.016248988,
-0.04848146,
0.0376488,
-0.0005791357,
0.009943212,
-0.015306441,
-0.004158493,
0.018519068,
0.0027313966,
0.016780002,
-0.026271854,
-0.010753007,
0.00481894,
-0.012817319,
0.007288149,
0.010295008,
-0.028940191,
0.00037606485,
0.03231212,
0.018479241,
0.025209827,
-0.035418548,
0.0028757656,
0.0008512797,
-0.040410068,
-0.0103481095,
0.023603514,
-0.0066575715,
-0.025156727,
-0.0062294425,
0.018545618,
0.034117565,
-0.013215578,
0.011131354,
0.01057379,
-0.011257469,
-0.00037523513,
-0.014058561,
0.0026799547,
0.0067637744,
-0.01729774
] |
Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identification of novel targets for pain therapy, classical study designs provide unclear results owing to the differential expression of hundreds of genes across sham and nerve-injured groups, which can be difficult to validate, particularly with respect to the specificity of pain modulation. To circumvent this, we used two outbred lines of rats, which are genetically similar except for being genetically segregated as a result of selective breeding for differences in neuropathic pain hypersensitivity. SerpinA3N, a | [
-0.020738477,
0.0016548284,
0.0052186167,
-0.026980419,
-0.010192451,
0.011178379,
0.0025532125,
-0.0020041529,
-0.04177613,
-0.023036707,
-0.014782114,
-0.007037483,
-0.0021809398,
0.005082627,
0.0056435857,
0.02491337,
0.04585583,
-0.006660111,
0.023839049,
0.019827344,
-0.033807117,
0.022383956,
0.0074658515,
-0.028557902,
-0.015530059,
0.011008391,
0.0029084864,
-0.043979168,
-0.022383956,
-0.016019624,
-0.008274992,
0.0022404355,
-0.013510607,
0.000043692104,
-0.01742032,
-0.0042734863,
0.0121031115,
-0.027198002,
0.02068408,
0.009954469,
0.019582562,
0.007703834,
0.012443086,
0.0048140464,
0.0014091965,
-0.016427593,
-0.0032790592,
-0.013585402,
-0.01321143,
0.01279666,
0.02003133,
0.023104703,
-0.024532598,
0.00026454308,
-0.0034354476,
-0.013245427,
0.03089693,
0.007282265,
0.008995739,
-0.008866549,
-0.010505228,
0.017705899,
-0.028122734,
0.025430132,
-0.0190658,
-0.011613547,
-0.007363859,
0.008812153,
0.022152772,
-0.022955114,
0.035221413,
0.018032275,
-0.028122734,
-0.0017398222,
0.016400395,
-0.0023611265,
-0.0030053793,
-0.0036139346,
0.00830899,
-0.0016284804,
0.018426647,
-0.030053793,
-0.0204257,
0.013510607,
0.025362138,
-0.0044060764,
0.0045930627,
0.0036241338,
0.0022897318,
-0.0033759521,
0.013082239,
0.027714765,
0.004956836,
-0.0004328307,
0.003756724,
0.023594268,
0.0034337477,
0.015761243,
-0.003498343,
-0.023784652,
-0.01661798,
0.01716194,
0.0013327021,
-0.02640926,
-0.012959848,
-0.011450359,
-0.0049466365,
-0.004888841,
0.031223306,
-0.0021894393,
0.0062283427,
0.026218874,
-0.017909884,
-0.020099323,
0.037098076,
-0.011123983,
0.041476954,
-0.020398501,
0.0042938846,
-0.012035116,
0.0040865,
0.002981581,
0.0056027886,
-0.0058067734,
0.028911477,
0.03255601,
-0.013191031,
-0.002070448,
-0.022261566,
-0.00517102,
-0.0030393768,
0.00313287,
0.044686317,
0.016264405,
-0.033099968,
0.007343461,
-0.014360545,
-0.014265352,
-0.02356707,
-0.03432388,
-0.0064867237,
0.02273753,
-0.033943105,
0.0024971166,
0.00354254,
0.040389035,
0.014142961,
0.010471231,
0.022778327,
0.0006174797,
0.0036105348,
-0.018086672,
-0.007431854,
-0.0163596,
0.00088818476,
-0.004151095,
0.021037655,
0.03331755,
-0.004307484,
0.0108860005,
-0.0010649718,
-0.008472178,
-0.0019752549,
0.007091879,
0.004868442,
0.016699573,
0.014115763,
-0.005568791,
0.004246288,
-0.015992425,
-0.027279597,
0.008370185,
-0.0018273658,
0.030135386,
-0.013517407,
0.0025464129,
-0.0044332743,
0.0089345435,
-0.0062827384,
-0.005949563,
-0.016672375,
0.0043380815,
0.0032161637,
-0.001592783,
-0.009634892,
0.017393123,
0.027401987,
-0.021826398,
0.0094173085,
-0.01008366,
-0.015598054,
0.004072901,
0.0016106317,
-0.025838101,
-0.64622456,
-0.019786546,
0.016957954,
-0.010947196,
-0.00058178225,
0.030951327,
0.008268192,
-0.021459224,
-0.017202737,
0.02492697,
-0.0058237724,
0.023988638,
0.023798252,
-0.02095606,
-0.016794767,
-0.020398501,
-0.0078330245,
-0.01456453,
0.031821664,
-0.0039947066,
-0.006976288,
0.00018751748,
0.0013811486,
0.0146053275,
0.0073094633,
0.020439299,
0.0025022163,
-0.027905151,
-0.014850109,
0.013469811,
-0.024410207,
0.00857417,
-0.02054809,
-0.023186296,
0.056952618,
-0.0011763136,
0.012327494,
0.03250161,
0.035438996,
0.026803631,
-0.039029133,
-0.0031838662,
0.008757757,
0.0059121656,
-0.039029133,
0.023118302,
0.014632525,
-0.008594569,
0.0038077203,
-0.0060209576,
0.019786546,
-0.006928691,
-0.018277058,
0.0038213194,
0.011389163,
-0.02547093,
0.016087618,
-0.021187244,
0.026055686,
0.012368292,
0.0064765243,
0.0083497865,
-0.010376038,
-0.026273271,
-0.008642165,
0.005283212,
-0.032066446,
-0.015081292,
-0.0060617547,
0.0034371475,
0.013191031,
0.025661316,
0.007901019,
0.011395963,
0.023254292,
0.027021214,
-0.00585437,
0.019432973,
-0.02477738,
0.0023424278,
-0.017855488,
-0.00007899107,
-0.040470626,
0.00788742,
0.02329509,
-0.002218337,
-0.020303309,
0.019228987,
0.013578603,
-0.01171554,
-0.0015256379,
0.007860223,
-0.024858974,
-0.03962749,
-0.015258079,
0.019854542,
0.005908766,
0.015584455,
0.000006523935,
-0.027537977,
-0.028557902,
-0.007996213,
0.0024291216,
-0.019147394,
0.016563583,
0.007513448,
0.0012902053,
0.03201205,
0.029101862,
-0.0014117463,
-0.014115763,
-0.0033776518,
-0.009043336,
-0.021173645,
0.008206997,
-0.018943409,
0.021092052,
-0.016413994,
-0.021200843,
-0.03799561,
0.005799974,
-0.009077333,
0.003906313,
0.0037329257,
0.032311227,
-0.006612514,
-0.0059699616,
-0.013585402,
-0.0027198002,
-0.022492748,
0.0030427766,
-0.007581443,
-0.004715454,
-0.020248912,
0.002165641,
0.0006497773,
0.014102165,
0.0121031115,
0.0025753109,
-0.035846967,
0.006136549,
0.008506175,
0.00024414455,
0.0033844514,
0.0021333434,
0.007914619,
-0.012477083,
-0.0043108836,
0.0076970346,
-0.005052029,
0.010321642,
-0.014945302,
-0.0013539506,
0.010097259,
0.011967121,
-0.013531006,
-0.0048820414,
-0.021064853,
-0.010532427,
-0.011259973,
0.00612635,
0.0062113437,
-0.025538925,
0.023730258,
-0.024627792,
-0.030652149,
-0.0002764422,
0.037914015,
-0.004242888,
-0.017488316,
-0.0060515557,
-0.010947196,
-0.010960795,
0.011382364,
0.014741317,
-0.0008125403,
0.009750484,
-0.018345052,
-0.008424581,
0.00858097,
-0.008322589,
-0.009872875,
-0.018970607,
-0.0019157593,
0.033263158,
0.024491802,
0.024247019,
0.021853594,
0.023852648,
0.02139123,
-0.020044928,
0.01334742,
-0.04411516,
0.04536627,
-0.034514263,
-0.00435168,
0.015094891,
0.0107024135,
0.018576236,
0.029917803,
0.014414941,
-0.029183457,
-0.016019624,
-0.0060107587,
0.036282133,
-0.04928278,
0.007295864,
-0.012069114,
0.00074964494,
-0.022941515,
0.0006633763,
0.028476309,
-0.008363386,
-0.02356707,
-0.016549984,
0.028285922,
-0.016006025,
0.010525627,
0.0042734863,
-0.017624306,
-0.0025804106,
-0.0023764255,
0.0015978826,
0.01075681,
-0.017828291,
0.030026594,
0.008866549,
0.027306795,
0.01838585,
-0.023893446,
0.0010318242,
0.028231526,
-0.0061603477,
0.0052866116,
0.009696088,
-0.0035085422,
0.014918104,
-0.023036707,
0.031087317,
0.013993372,
-0.004807247,
0.03299118,
0.0066091144,
0.007581443,
-0.005925765,
0.0071258764,
0.004399277,
0.010274045,
-0.0023492274,
0.016903559,
0.008111804,
0.0066193137,
-0.021989584,
-0.015081292,
-0.0015859836,
-0.023580668,
0.0028829882,
0.024301415,
0.039165124,
0.0060107587,
0.008621767,
-0.012443086,
0.010913199,
-0.0065377196,
0.041068982,
0.0037431251,
-0.0054769977,
0.000034024062,
0.0041578948,
0.008961742,
-0.0034694453,
-0.00994087,
-0.009478504,
-0.006306537,
0.01740672,
-0.0066363127,
-0.0012154108,
0.008540173,
0.03527581,
0.008030211,
-0.035901364,
-0.037206866,
0.030461762,
0.018426647,
-0.009430908,
-0.0012477083,
-0.021364031,
0.008778155,
-0.017923484,
-0.0190522,
0.013728192,
0.0014049468,
-0.0064731245,
-0.00044579225,
-0.0008949843,
0.010423634,
0.037506044,
-0.009009338,
-0.000018154135,
-0.01892981,
0.020357706,
-0.0078330245,
-0.0111851785,
-0.025076559,
0.038729955,
0.02069768,
-0.024804577,
-0.0090841325,
-0.009866076,
-0.016427593,
0.017569909,
-0.013714593,
0.004735852,
-0.009913672,
0.01210991,
0.01687636,
0.01021285,
0.01538047,
0.039110728,
-0.0060787536,
0.00925412,
-0.029183457,
-0.0026297069,
-0.00051633705,
0.027469981,
0.012694668,
0.0010981193,
-0.0010896199,
0.017338727,
-0.015720446,
-0.014890906,
-0.01034204,
0.015462064,
-0.005123424,
-0.005361406,
-0.0017610707,
0.017202737,
0.013401816,
0.0016709772,
0.025103755,
-0.0036445323,
-0.031631276,
-0.0016837263,
0.00040648264,
0.0041000987,
0.0032467616,
0.007907819,
0.026586046,
0.008288591,
-0.017311528,
0.01578844,
0.018970607,
0.012320695,
-0.013000645,
-0.017365925,
-0.00076154404,
-0.011205577,
0.024328614,
-0.034432672,
-0.009560098,
-0.014129362,
0.0023900245,
0.019541765,
0.013163833,
0.017923484,
0.014537333,
0.025389336,
0.008961742,
-0.022778327,
-0.006007359,
0.0034337477,
-0.006245341,
-0.010097259,
-0.0035731376,
0.004198692,
-0.018725825,
-0.015938029,
0.00001745028,
0.025171751,
0.0077922274,
0.0055483924,
0.0052594137,
-0.0032603606,
0.001060722,
-0.012082713,
-0.012259499,
0.013225028,
-0.029863406,
-0.019351378,
-0.032447215,
0.012551878,
0.007234669,
-0.007601842,
0.003335155,
-0.0020262513,
-0.007513448,
-0.028285922,
0.010308043,
0.0024444205,
0.0024529197,
0.026218874,
-0.023594268,
0.013864182,
0.04455033,
-0.0121031115,
-0.026273271,
0.013293023,
-0.0063643325,
0.026450057,
0.0033878512,
-0.017773895,
-0.018005077,
-0.021622412,
-0.0074386536,
0.020493696,
-0.025430132,
0.008839351,
0.019446572,
0.008247795,
0.0071530747,
0.026762834,
0.027415587,
0.0052866116,
-0.022084778,
0.003253561,
-0.015883634,
-0.021432025,
-0.033834316,
0.008240995,
-0.008234195,
0.0124702845,
0.0030801739,
0.00571838,
-0.016957954,
0.03497663,
0.0022574342,
-0.008499376,
-0.0022217368,
0.0037737228,
0.01660438,
-0.023648662,
0.015842836,
0.021486422,
0.0054565994,
0.007499849,
0.0071394756,
0.027469981,
-0.00072499673,
-0.032311227,
0.014102165,
-0.0055925893,
-0.02479098,
-0.019256186,
-0.001971855,
-0.0033691525,
0.04985394,
0.014401342,
-0.030869734,
-0.016264405,
-0.0117699355,
-0.0068844943,
0.0017347226,
-0.0060413564,
-0.0053342083,
-0.0089345435,
0.0045250678,
0.0016429293,
-0.017869087,
0.022941515,
-0.040089857,
-0.015584455,
0.0036955285,
-0.0036853293,
0.0065989154,
0.0029594826,
0.004096699,
-0.0064731245,
-0.01170874,
-0.022411155,
-0.010682016,
0.0015443366,
0.01184473,
0.014646124,
0.045284674,
0.016142014,
-0.0016446292,
-0.016019624,
0.03745165,
-0.012157507,
0.01917459,
-0.011409562,
-0.007282265,
-0.027578775,
0.03035297,
0.00039819576,
-0.0067995004,
0.022288762,
-0.029183457,
0.036173344,
0.022642337,
-0.01020605,
-0.029727416,
-0.007799027,
-0.033861514,
-0.02082007,
0.026354864,
-0.009206524,
0.02056169,
-0.03921952,
0.004134096,
0.015434867,
-0.011334768,
-0.0031243705,
-0.016318802,
0.025688512,
-0.006602315,
0.03979068,
-0.016985152,
0.0075746435,
-0.014006971,
-0.003455846,
-0.0043210825,
0.0063915304,
-0.015978826,
-0.004868442,
0.013585402,
-0.0046882555,
-0.0024070232,
-0.019514566,
0.019215388,
-0.019106597,
0.005184619,
-0.0029645823,
-0.01510849,
-0.021867193,
-0.0011261672,
-0.013918578,
-0.03552059,
0.017597107,
0.0034915435,
-0.022914317,
0.025348539,
-0.03881155,
0.005011232,
0.0043584798,
-0.012211903,
0.008220596,
-0.009607694,
0.0449311,
0.016944356,
0.006136549,
-0.015271679,
-0.016305203,
-0.011824331,
-0.024111029,
0.029890604,
-0.0017253733,
0.0076562376,
-0.016006025,
0.0016879761,
0.0049194386,
-0.026735635,
-0.026327666,
0.0327192,
-0.0068980935,
-0.0031498687,
-0.0030019796,
-0.019419374,
-0.017175538,
0.022832723,
-0.027687566,
0.029319447,
-0.009730086,
-0.022166371,
-0.0125042815,
0.02598769,
0.0050894264,
0.048820414,
-0.002111245,
-0.010505228,
-0.019337779,
-0.004436674,
0.0019157593,
-0.014890906,
0.0058033736,
0.024831776,
-0.003960709,
-0.017882686,
-0.00058518205,
0.012205103,
0.0046644574,
0.0050724274,
-0.00926092,
0.04259207,
-0.016318802,
-0.015040495,
0.02394784,
-0.012354692,
0.0037873217,
-0.0044706715,
-0.0077242325,
-0.012844256,
-0.023104703,
0.006286138,
0.016250806,
-0.0039981063,
0.0033096569,
0.010199251,
-0.019541765,
-0.027932348,
-0.018834617,
-0.018277058,
-0.005636786,
-0.025878899,
0.0068538967,
-0.0050316304,
0.013095838,
0.009437707,
0.0030869732,
-0.0031192708,
0.0011618646,
0.0056945817,
-0.03157688,
0.02054809,
0.004368679,
0.026178077,
-0.028965872,
0.023607867,
-0.023866247,
-0.036282133,
0.027646769,
-0.03772363,
-0.024858974,
0.005840771,
0.00023352035,
0.008329388,
-0.0053682057,
-0.0062521407,
0.008995739,
0.013184232,
0.015298876,
-0.01577484,
-0.010138055,
0.0017491715,
-0.027429186,
-0.00058773183,
-0.018821018,
-0.018426647,
0.0015987325,
-0.029210655,
-0.00926092,
0.022003183,
-0.020983258,
-0.015230881,
-0.00038757152,
0.011525153,
-0.016019624,
-0.0067315055,
-0.0071802726,
-0.011735938,
-0.025838101,
0.0041578948,
0.023730258,
-0.022778327,
-0.024111029,
-0.0020908464,
-0.004712054,
-0.0030835734,
-0.022383956,
-0.013041442,
-0.0036547317,
-0.02394784,
-0.0517034,
-0.0015587856,
-0.02763317,
0.04112338,
0.01034204,
-0.005065628,
-0.02273753,
-0.0004942387,
-0.047215734,
0.010729612,
-0.0067519043,
0.0030070792,
0.020398501,
0.027728364,
-0.006551319,
0.0071258764,
0.002435921,
0.026790032,
-0.008383784,
-0.01238869,
0.0033691525,
0.0045284675,
0.01797788,
0.022424754,
-0.018426647,
-0.022424754,
0.030733742,
-0.002818393,
-0.0060651544,
0.0045318673,
-0.017107543,
0.020901665,
0.0013055041,
0.007914619,
0.0032552609,
-0.020860868,
0.026014889,
-0.039165124,
-0.01674037,
0.0008201898,
-0.0018290656,
-0.007969014,
-0.008281792,
0.032202434,
-0.004807247,
0.0012851056,
-0.032583207,
-0.022139173,
-0.017515514,
-0.000911983,
0.014537333,
0.040797003,
-0.024559796,
0.022247966,
0.00913173,
-0.0028778887,
-0.015625251,
-0.011321168,
0.004113698,
0.0014227955,
-0.006031157,
-0.01211671,
0.015462064,
-0.0041238973,
0.0034269483,
-0.017746696,
-0.019473769,
-0.015883634,
-0.0089005465,
-0.014142961,
0.00204495,
0.011695141,
-0.009974867,
-0.009220122,
-0.0023322287,
-0.018453844,
-0.0044672717,
-0.01878022,
-0.0052356157,
-0.03834918,
-0.009029737,
-0.007663037,
-0.0061025517,
-0.017216336,
-0.028530704,
-0.029564228,
-0.024722984,
0.020901665,
0.16732211,
-0.007459052,
0.012579076,
-0.002002453,
0.0231455,
-0.0024444205,
0.012735465,
0.0016599281,
-0.022832723,
0.010858802,
0.041041784,
-0.001851164,
0.0018919611,
-0.0011185178,
0.008948143,
-0.03154968,
-0.022139173,
-0.008281792,
-0.019555364,
-0.0050996253,
0.017964281,
-0.004674657,
0.031359296,
-0.00830899,
0.027877953,
0.035765372,
-0.03255601,
-0.0021962386,
0.01812747,
-0.008417781,
-0.028177131,
0.019936135,
0.0018205662,
0.008594569,
-0.001062422,
0.016223608,
0.00011378539,
0.0052492144,
-0.0021741404,
0.020371303,
0.00353914,
0.008648965,
-0.005745578,
-0.010682016,
0.0000030611034,
-0.0038315186,
-0.0011967121,
-0.0013658496,
-0.010559624,
0.0119195245,
-0.028911477,
0.010369238,
0.02001773,
0.020112922,
-0.014115763,
-0.02192159,
0.016114816,
0.014102165,
0.010423634,
0.04193932,
-0.013762189,
-0.0056129876,
-0.011661143,
0.030597752,
0.007323062,
0.026232474,
-0.012755863,
-0.009356113,
0.008635365,
-0.0011389164,
0.019092998,
-0.0140885655,
-0.016808365,
0.014061367,
-0.006313336,
-0.006027757,
0.042918447,
0.007941817,
-0.0075678444,
0.0022030382,
0.025674915,
-0.013850583,
-0.020711279,
0.0135378055,
-0.015706846,
-0.032855187,
0.025661316,
0.008152601,
-0.0032314626,
0.0018001677,
0.009621293,
-0.0046882555,
-0.006085553,
-0.025552522,
0.008009812,
0.005432801,
0.010049662,
-0.0042530876,
-0.013938976,
-0.004314283,
-0.030053793,
0.06843017,
-0.012409088,
0.03225683,
-0.016019624,
0.00022395854,
-0.0009927271,
-0.0069524893,
0.0008839351,
0.011443559,
0.00858097,
0.0021061453,
0.016182812,
-0.03481344,
0.012572276,
0.02273753,
0.0003406125,
-0.039817877,
0.015285278,
0.00057625765,
-0.017814692,
-0.01988174,
-0.013136636,
0.017733097,
0.0133542195,
-0.014686922,
-0.001783169,
-0.004331282,
0.008798554,
-0.019976933,
-0.019364977,
-0.011491156,
0.0022574342,
-0.0008006412,
-0.008132203,
0.007710634,
-0.009349314,
0.0067553036,
-0.0037363255,
0.017365925,
-0.014183758,
-0.017175538,
-0.0015834337,
0.013830184,
0.0024002236,
-0.00871016,
0.024695786,
-0.001212011,
-0.0041612945,
-0.0032790592,
-0.02926505,
-0.02560692,
0.009594095,
-0.0061705466,
0.026844429,
-0.027850755,
-0.042673666,
-0.0258653,
-0.0028234925,
0.0010947196,
-0.03277359,
0.0013318522,
0.010593622,
0.011429961,
0.0038451175,
-0.0009833778,
-0.17265292,
0.01742032,
0.019840943,
-0.032583207,
0.022982312,
0.031767268,
0.007554245,
-0.007404656,
0.0006060055,
0.022791926,
0.031250503,
-0.0067961006,
-0.01417016,
-0.042700864,
0.0048412443,
0.0006034557,
-0.008696562,
0.038403578,
0.011735938,
0.013231828,
0.0076766363,
-0.0023305288,
0.016590782,
-0.013565004,
0.006003959,
0.017828291,
-0.012069114,
-0.009111331,
-0.0032620605,
-0.020493696,
-0.0056741834,
0.011246374,
0.031386495,
0.0022710331,
0.017107543,
0.012218703,
-0.008077807,
-0.013279425,
-0.021119248,
0.022615138,
0.013089038,
0.027021214,
0.02749718,
-0.0136126,
-0.008778155,
-0.014850109,
0.020452898,
0.0057931743,
0.0097844815,
-0.0009340814,
0.0076766363,
0.007023884,
0.017610706,
0.018902611,
0.05624547,
0.024491802,
0.023390282,
0.002301631,
-0.01197392,
-0.020643285,
-0.011089985,
-0.019555364,
0.0285851,
0.0204121,
-0.0026654042,
-0.008077807,
0.0002573186,
-0.0013938976,
-0.023376683,
0.019582562,
-0.034867838,
-0.0027418986,
0.0153396735,
-0.036010154,
0.016713172,
0.015761243,
0.012885054,
0.0030308773,
-0.0028370917,
-0.0008125403,
-0.0074862503,
-0.0067451047,
-0.007867022,
-0.020520892,
0.008336187,
0.025933295,
0.037179668,
0.014034169,
0.020928863,
-0.004463872,
0.0077174334,
-0.02204398,
-0.002750398,
-0.0136126,
0.018997805,
0.004589663,
0.011987519,
-0.0017593708,
-0.0008044659,
-0.014782114,
0.015910832,
0.011545552,
-0.015298876,
0.014047768,
0.028476309,
-0.0018885613,
-0.029727416,
-0.0016182811,
0.030869734,
0.013993372,
-0.0070510823,
-0.00087628566,
-0.0066771097,
0.0039131125,
-0.00011644145,
0.019623358,
0.0009502302,
-0.012558677,
0.044740714,
-0.016006025,
0.078602225,
-0.017488316,
0.01688996,
0.03293678,
-0.00033997503,
-0.028476309,
-0.13653398,
-0.02642286,
0.009220122,
-0.0009374811,
-0.014877307,
-0.0059971595,
0.003960709,
0.04259207,
-0.021554416,
0.020928863,
-0.01648199,
-0.012993845,
0.021200843,
-0.0057421783,
0.021445625,
-0.015870035,
0.00055500923,
0.0036377327,
-0.017746696,
0.03174007,
-0.009186125,
0.013578603,
0.022914317,
-0.008098206,
0.0031107715,
0.019133795,
-0.015802039,
-0.0024614192,
0.003416749,
-0.014047768,
0.011790334,
-0.0077650296,
0.019555364,
-0.0007679186,
-0.019337779,
-0.016767569,
0.008818952,
-0.038430776,
0.047433317,
-0.007873822,
0.0064765243,
-0.0024971166,
0.033834316,
0.031223306,
-0.019718552,
-0.0033436543,
-0.0019752549,
0.012565477,
0.022479149,
-0.01008366,
-0.021812798,
-0.013857382,
0.005082627,
-0.0050962255,
0.035629384,
-0.012551878,
0.004304084,
0.0024410207,
-0.0011618646,
-0.01701235,
-0.010600422,
0.015135689,
0.0014015471,
0.01648199,
0.012143908,
-0.0039675087,
-0.03448707,
-0.03976348,
0.025797306,
0.00028260425,
0.00939691,
-0.010505228,
-0.0062589403,
0.004304084,
-0.04642699,
0.0032314626,
-0.012089512,
-0.022343159,
0.011423161,
0.0050554285,
-0.022955114,
-0.00830899,
0.023893446,
-0.0070578814,
0.015353273,
0.029455436,
0.008485776,
-0.008784954,
-0.005908766,
-0.017243534,
-0.021432025,
0.018290656,
-0.007812626,
-0.013286225,
-0.0074250544,
-0.00870336,
-0.0007020484,
0.0019361578,
0.008465379,
0.018440245,
-0.0078058266,
-0.010328441,
-0.035738174,
0.02734759,
0.0018443646,
-0.025103755,
0.0077786287,
-0.007282265,
0.022574343,
0.002952683,
-0.021772001,
-0.010838404,
-0.020860868,
0.027823556,
0.002507316,
0.0000785661,
-0.035683777,
-0.022710333,
0.04871162,
0.0068572965,
0.009913672,
0.0051948186,
0.013728192,
-0.017624306,
0.0025430133,
0.029074665,
-0.01183793,
-0.015666049,
-0.015734045,
0.011470757,
-0.02000413,
0.0006230042,
-0.010144855,
-0.052056976,
0.006075354,
0.014387744,
-0.014061367,
-0.012585876,
0.027469981,
0.028041141,
0.014714119,
0.033453543,
-0.044033565,
-0.025430132,
0.007452253,
-0.009716487,
0.008478977,
0.010240048,
-0.04006266,
0.01280346,
-0.0073706587,
-0.01824986,
0.024383008,
0.01701235,
-0.0030563755,
-0.022628738,
-0.035629384,
0.010634419,
-0.008404182,
0.01007006,
-0.018018676,
-0.013762189,
0.024586994,
0.0070170844,
0.01826346,
-0.0003937336,
-0.024831776,
-0.0038213194,
-0.02068408,
0.0044910703,
0.00073732086,
-0.015448465,
-0.0105188275,
-0.00030045293,
0.016318802,
0.0015281878,
0.008961742,
0.007173473,
-0.0071666734,
-0.013925377,
-0.01510849,
0.02258794,
0.022220768,
0.017175538,
-0.016033223,
0.008540173,
0.019528165,
-0.00042943095,
-0.011055988,
-0.00830219,
0.002231936,
-0.0033334552,
0.0042836852,
0.013830184,
0.019378576,
0.013102638,
0.007554245,
0.019976933,
-0.013993372,
-0.013429014,
0.011266773,
0.007499849,
-0.018603433,
0.021540819,
0.025838101,
-0.036010154,
-0.022683134,
0.0029016868,
-0.052492145,
-0.012633472,
-0.004752851,
0.0042156903,
0.017909884,
0.002711301,
-0.02776916,
-0.0032620605,
-0.01157955,
0.002055149,
-0.011368765,
-0.010090459,
-0.02533494,
0.01334062,
0.00463046,
0.008601368,
-0.0154892625,
0.0024835176,
0.0009408809,
-0.004861643,
0.029319447,
-0.010131256,
0.023444679,
0.004504669,
-0.0021418426,
-0.003171967,
-0.025661316,
0.014442139,
0.0028761888,
-0.041014586,
-0.013809785,
0.007608641,
-0.017175538,
0.0694637,
-0.008268192,
0.014754917,
0.002259134,
-0.0030580754,
0.01347661,
-0.014333347,
0.012483883,
0.003977708,
-0.035058226,
0.013775788,
-0.029455436,
0.038974736,
-0.043462407,
-0.017189138,
0.034514263,
-0.024478203,
0.020303309,
-0.006044756,
-0.00088308513,
0.013286225,
-0.001320803,
0.01062082,
-0.0014516934,
-0.012218703,
0.0073774583,
0.027673967,
-0.004300684,
0.014210956,
-0.007499849,
0.0031617677,
-0.013157033,
-0.03775083,
-0.0056571844,
-0.013979773,
-0.0074658515,
-0.0023169299,
-0.00069949863,
0.022859922,
0.0060413564,
0.018535439,
0.03277359,
-0.023920642,
-0.008125403,
0.024301415,
-0.0011287171,
-0.014632525,
-0.0048582433,
-0.013653398
] |
The protein cross-linking enzyme tissue transglutaminase binds in vitro with high affinity to fibronectin via its 42-kD gelatin-binding domain. Here we report that cell surface transglutaminase mediates adhesion and spreading of cells on the 42-kD fibronectin fragment, which lacks integrin-binding motifs. Overexpression of tissue transglutaminase increases its amount on the cell surface, enhances adhesion and spreading on fibronectin and its 42-kD fragment, enlarges focal adhesions, and amplifies adhesion-dependent phosphorylation of focal adhesion kinase. | [
-0.032854773,
0.0012689603,
-0.003433753,
0.005960293,
-0.012609938,
0.0008356766,
-0.03345308,
0.009533867,
-0.022774627,
-0.00832425,
0.02806833,
-0.014411357,
0.013865079,
0.0052644378,
-0.016128235,
0.0052579343,
0.026871718,
0.0029736431,
-0.041907396,
-0.0033654682,
-0.015855094,
-0.0029801466,
-0.01482757,
-0.010912571,
-0.03719899,
0.028926767,
0.017637005,
-0.037537165,
-0.012935104,
-0.014411357,
-0.006025326,
0.0035150445,
-0.038993906,
0.014424364,
0.007530845,
-0.014177238,
-0.0038011908,
0.0201733,
0.012642454,
-0.00035585355,
0.025883215,
-0.00041499312,
0.010776002,
0.0044645295,
-0.0009299748,
-0.004848225,
0.0011088161,
-0.009794001,
-0.026143348,
0.013617952,
-0.009234714,
0.016908633,
-0.013787039,
-0.006685413,
-0.0193929,
-0.022852667,
0.018326357,
0.0022160064,
0.0019396152,
-0.026182367,
-0.023099793,
0.007595878,
-0.0151657425,
-0.015581955,
-0.0006495191,
0.025870208,
-0.0054010074,
0.0152567895,
-0.015412869,
-0.006249691,
0.016232288,
0.027313944,
0.0026566063,
-0.02942102,
0.021265857,
-0.017402885,
-0.0089680785,
0.014359331,
-0.02264456,
0.014242271,
0.012518891,
-0.020069245,
0.012057155,
0.047682345,
-0.0039345087,
0.0024322418,
-0.0035182962,
0.002775292,
-0.0023476987,
0.007901534,
0.012401831,
0.037719257,
0.003684131,
0.037771285,
-0.016908633,
0.000114824245,
-0.0071146325,
0.03797939,
-0.016700527,
-0.027730158,
0.012609938,
0.0197831,
0.0023607053,
-0.018144263,
-0.016635492,
-0.011387314,
0.016375361,
-0.010554888,
0.003999542,
-0.031398028,
-0.02718388,
0.027756171,
-0.009794001,
-0.0264425,
0.004389741,
0.0051896493,
0.027235905,
-0.01792315,
-0.012707488,
-0.024803663,
0.012954614,
0.017845111,
0.02694976,
-0.01866453,
0.024244377,
0.03860371,
0.015100709,
0.0015607969,
-0.01594614,
0.0039832834,
0.021304877,
0.023008747,
0.006887016,
0.018872635,
-0.01649242,
-0.0020387908,
-0.01153689,
-0.018976688,
-0.007797481,
-0.03306288,
0.011432837,
0.031450056,
-0.017663017,
0.0022160064,
0.0052254177,
0.021499977,
0.021239843,
0.006743943,
0.028666636,
0.027938263,
-0.002199748,
-0.007069109,
0.0061944127,
0.0028013051,
-0.0047311652,
0.013904098,
-0.02791225,
0.014996656,
-0.024335423,
-0.01302615,
-0.00020973208,
-0.0052091596,
0.023997251,
0.016128235,
0.012700984,
0.031970322,
-0.0005775761,
0.0019396152,
0.008454316,
-0.02597426,
0.005586352,
0.023867184,
-0.03727703,
0.027209891,
-0.0011031257,
-0.017441904,
-0.0029297457,
0.009995603,
-0.0014494275,
-0.021317884,
-0.012278268,
0.011679963,
0.023320906,
-0.008610396,
-0.02434843,
-0.0065325852,
0.023099793,
-0.0073422487,
0.004201145,
-0.029837234,
-0.0047409204,
0.024530524,
0.014346324,
-0.031502083,
-0.6347241,
-0.020355392,
0.04099693,
0.0030305472,
-0.00022578715,
0.03860371,
0.00957939,
-0.008259216,
-0.023672085,
0.00599281,
-0.008701443,
0.020030227,
0.002113579,
-0.022540508,
-0.016622486,
-0.03345308,
-0.012161208,
-0.013904098,
0.010268742,
0.01827433,
-0.01827433,
0.0016298946,
0.0027005037,
0.025115823,
0.026923746,
0.008506343,
0.026871718,
-0.023489993,
-0.0038304557,
0.017623998,
-0.042531714,
0.031814244,
-0.0042369133,
0.009995603,
0.05090799,
-0.016245294,
-0.021005724,
0.020914678,
0.021981223,
0.037849322,
-0.0120896725,
-0.019614013,
0.012622944,
0.00485798,
-0.009644424,
0.00971596,
0.00038410234,
0.013539913,
0.0032662926,
-0.006132631,
-0.013539913,
-0.007654408,
-0.035352048,
-0.0030451796,
-0.00026887163,
0.011062148,
0.024244377,
-0.010190703,
0.023828166,
0.00017965422,
0.016791573,
0.030981818,
-0.011341791,
-0.030227432,
-0.017285826,
-0.020225326,
-0.015842088,
0.022202335,
0.013669979,
0.01513973,
0.017793084,
0.0403466,
0.015126723,
0.020836638,
0.012206732,
0.037485138,
0.009130661,
0.02287868,
0.0021542248,
-0.0010649187,
0.00079462444,
-0.003282551,
-0.006704923,
0.027860224,
0.027261918,
0.01157591,
-0.032230455,
0.019002702,
0.0059147696,
0.0117449965,
0.004373483,
0.016193267,
-0.044352643,
-0.03673075,
-0.028432516,
0.022059262,
-0.008044607,
0.0100476295,
0.0053619873,
0.004331211,
-0.0044612777,
-0.012473368,
0.014723517,
-0.013370826,
0.018651523,
-0.008733959,
-0.049529288,
0.023333913,
0.049217127,
-0.0152567895,
0.0068935193,
-0.0015087703,
-0.01186856,
-0.024478497,
-0.0019672543,
-0.018326357,
-0.0042239064,
0.010164689,
-0.0041751317,
-0.04315603,
0.002754156,
0.00034386307,
0.011855553,
0.013891092,
0.028978795,
-0.00579771,
0.0070561026,
-0.025076803,
-0.0020534233,
-0.0003879637,
-0.008499839,
0.0011145065,
0.012551408,
-0.017949164,
0.0030061598,
0.015907122,
0.03566421,
0.015009663,
0.0020322877,
-0.050491776,
-0.018248316,
-0.0031427294,
-0.0009681818,
-0.002344447,
-0.014697503,
-0.008350263,
-0.007426792,
0.016700527,
0.0058269748,
0.01141983,
-0.0012299404,
0.0019753836,
0.00009648285,
0.0147755435,
0.005787955,
-0.018937668,
0.002056675,
-0.04234962,
0.01815727,
-0.0029899015,
0.0038044422,
0.008447813,
-0.0019558736,
-0.012135196,
-0.012603435,
0.0036223494,
-0.008077124,
-0.002822441,
-0.009241218,
-0.047292143,
-0.0010478474,
-0.017324844,
-0.027131852,
0.021955209,
-0.006467552,
0.029264942,
0.003137852,
-0.0016282687,
-0.0020989466,
-0.00041316406,
-0.0060903593,
-0.003885734,
0.017493932,
0.003463018,
0.03790135,
0.0010462216,
0.021070758,
0.011914083,
-0.00848033,
0.016440393,
-0.012180719,
0.0046336157,
-0.026923746,
0.010717472,
-0.0032695443,
-0.015738035,
0.026273414,
-0.0012120563,
-0.026221387,
0.0020989466,
0.0057749483,
-0.0064155255,
0.016011175,
-0.012993634,
0.012245752,
-0.005443279,
-0.0067764595,
-0.025961254,
0.01943192,
-0.00840229,
-0.0050075566,
0.007895031,
-0.0021688573,
-0.012388825,
0.005365239,
0.014996656,
-0.016427387,
-0.018105244,
0.006665903,
-0.004503549,
0.0013705747,
0.001138894,
0.024868697,
0.002323311,
-0.024725623,
0.020043233,
0.011094664,
0.005261186,
-0.0048254635,
-0.023594046,
-0.01800119,
-0.0031980078,
0.014723517,
0.013448866,
-0.007927547,
-0.028380489,
0.005550584,
0.009039615,
0.041126996,
-0.004571834,
0.020693565,
0.010736981,
-0.001138894,
-0.008851019,
0.0063374857,
-0.0147755435,
0.00810964,
0.017702037,
0.013013144,
0.025766155,
0.015347836,
0.03756318,
-0.0074918247,
-0.005963545,
0.0051506297,
0.019601008,
0.014736524,
0.0074007786,
0.039228026,
0.030825738,
0.019067734,
0.0072902218,
-0.0069910693,
-0.008122647,
0.0060318294,
0.014918617,
0.019002702,
-0.031085871,
-0.018586488,
0.004477536,
-0.010697962,
-0.004831967,
0.027391985,
-0.029238928,
-0.00007519464,
0.0090721315,
0.015230776,
0.021773117,
0.0026159605,
0.022943713,
-0.022592535,
-0.044664804,
0.036132447,
0.011771009,
-0.015295809,
-0.007082116,
-0.00836327,
-0.009091642,
-0.0012486374,
-0.002679368,
0.008454316,
0.012798534,
0.029993312,
-0.00407433,
-0.0033914815,
-0.012076666,
0.03543009,
-0.024062285,
0.0058009615,
-0.015048683,
-0.0017558965,
-0.0011445844,
-0.0063472404,
-0.025909228,
0.04599148,
0.010106159,
-0.013318799,
-0.0038467138,
-0.01290909,
-0.031293977,
0.012284772,
0.0056969086,
-0.010223219,
-0.03543009,
-0.019457934,
0.008909549,
0.013500893,
-0.005488802,
0.029551087,
-0.009566384,
-0.019340875,
-0.008805496,
0.00499455,
-0.005852988,
0.0023672085,
0.040944904,
-0.002315182,
0.0019542477,
0.006295214,
0.01610222,
-0.0052839476,
-0.022943713,
-0.0065878634,
-0.02597426,
-0.00074869476,
-0.016622486,
0.014125211,
-0.013539913,
-0.0063765054,
0.018027203,
-0.011016624,
-0.013110694,
0.0074788183,
-0.0040223035,
0.013461873,
0.0044255094,
0.024608564,
0.026767666,
0.019093748,
-0.0014169109,
-0.009794001,
0.04138713,
-0.008629906,
-0.016388366,
0.003204511,
0.012544905,
0.008538859,
-0.0039345087,
-0.008350263,
-0.039228026,
0.0076283948,
0.0089225555,
0.0040645753,
-0.0023688343,
-0.0118490495,
0.013748019,
0.029082848,
0.015777055,
0.0010177696,
-0.020927684,
-0.0051441262,
0.0042921915,
-0.018352369,
-0.020810625,
0.014658484,
-0.011315777,
-0.0074788183,
-0.017220791,
-0.0035930844,
-0.021044744,
0.014606457,
-0.011426333,
0.0058139684,
-0.012193725,
-0.002199748,
-0.022072269,
-0.0110231275,
-0.01494463,
-0.01161493,
-0.029082848,
-0.021057751,
-0.012128692,
-0.008044607,
0.006454545,
0.0041198535,
-0.05431573,
-0.02423137,
-0.011010122,
0.004402748,
0.01006714,
0.007088619,
0.011049141,
0.0066073732,
0.033557132,
-0.013708999,
-0.009670437,
-0.012896084,
-0.027860224,
-0.010951592,
-0.008668926,
0.0023363177,
-0.024725623,
0.008077124,
-0.023021754,
0.008252713,
-0.0009624914,
-0.0023850927,
0.0021948705,
-0.0041491184,
-0.0022989237,
0.016830593,
0.0064870617,
0.012070162,
-0.011992122,
-0.0141902445,
-0.02160403,
-0.0035150445,
-0.03615846,
-0.0055408287,
0.01696066,
0.0015477902,
0.0068544997,
-0.02326888,
-0.014983649,
-0.0052676895,
0.0051213647,
0.0010299634,
0.009644424,
0.021591023,
0.020108266,
-0.0046271123,
0.021122783,
0.0049717883,
0.0014356079,
-0.0055343253,
-0.009195695,
0.020615526,
-0.023372933,
-0.02988926,
0.0015412869,
0.010977604,
-0.035065904,
-0.0020127776,
-0.0023997251,
-0.028484542,
0.02013428,
0.008629906,
-0.009761483,
-0.025558049,
-0.0023688343,
-0.023646072,
-0.009449325,
-0.0027720402,
-0.0012177468,
-0.02949906,
0.0099435765,
-0.01006714,
0.016661506,
-0.014970643,
-0.035560153,
-0.008649416,
0.018612502,
-0.011816532,
0.03142404,
-0.0001236647,
-0.013383833,
-0.00983302,
0.007043096,
-0.017194778,
-0.03696487,
-0.033088893,
-0.0025948246,
0.02659858,
0.024530524,
0.04013849,
0.017610991,
0.024803663,
-0.007680421,
0.0021412182,
0.020225326,
-0.022813648,
0.01819629,
-0.006808976,
0.015581955,
0.024413465,
0.00084624457,
0.051246163,
-0.022774627,
0.007394275,
0.008551866,
-0.026663613,
-0.020446438,
0.014151225,
-0.025440989,
-0.005358736,
0.018768582,
-0.0028777192,
0.000985253,
-0.038837828,
-0.0067894664,
0.0025427982,
0.005892008,
0.0024371191,
0.0027964276,
0.024595557,
-0.0020794366,
0.009689947,
-0.0006104992,
-0.0069975727,
-0.0034662697,
-0.012648958,
0.019835128,
-0.014450378,
0.027704144,
-0.0015364094,
-0.006321227,
-0.007823494,
0.00006798002,
-0.015816074,
-0.009527364,
-0.005079093,
-0.016778566,
0.0046076025,
-0.0065878634,
-0.013839065,
-0.016245294,
-0.016752552,
-0.018014196,
0.008603892,
0.014177238,
-0.026689626,
0.020329379,
0.003713396,
-0.015347836,
0.028094344,
0.005921273,
0.037407096,
-0.036054406,
0.00816817,
0.018014196,
0.0028370735,
-0.01310419,
-0.012993634,
0.0078039845,
0.0031037095,
0.027365971,
0.016700527,
-0.0030272955,
-0.013422853,
-0.011523884,
0.0070626056,
-0.014008151,
-0.030409526,
0.014034165,
0.0063147238,
-0.012135196,
-0.028926767,
-0.011562903,
-0.017350858,
0.007823494,
-0.00063773186,
-0.010171193,
0.0070040757,
-0.00334921,
-0.03155411,
0.044248592,
0.005882253,
0.034519624,
-0.0067309365,
-0.00499455,
-0.0018615754,
-0.016908633,
-0.004792947,
0.0013632585,
0.020849645,
0.01866453,
0.004474284,
0.007940554,
0.010795511,
0.008851019,
-0.0074593085,
-0.010925578,
0.005244928,
0.03615846,
0.010281749,
-0.008707946,
0.0033947332,
0.020004213,
0.008870529,
-0.017233798,
0.010164689,
0.0027411494,
-0.025453996,
-0.015321823,
0.023060773,
0.027470024,
-0.013669979,
0.008545362,
-0.004640119,
-0.0040905885,
-0.0358463,
-0.027626105,
0.005137623,
-0.050465766,
-0.03137202,
0.002458255,
0.0291869,
0.017246805,
0.0014453629,
0.007537348,
-0.0022062515,
0.03774527,
-0.034129426,
0.010808518,
-0.00043856766,
0.013208243,
-0.010802015,
-0.015178749,
-0.007940554,
-0.017715044,
0.0020696817,
-0.014151225,
-0.011725486,
0.00503357,
0.0015055187,
-0.00040320586,
0.024725623,
-0.04552324,
0.028380489,
-0.014476391,
0.037303045,
0.015308816,
0.0058692466,
0.00202741,
-0.0065488433,
0.0024159835,
0.01641438,
0.005735928,
-0.022007236,
0.027105838,
-0.033088893,
-0.0111141745,
-0.0053977557,
-0.020082252,
-0.032178428,
-0.014463384,
-0.014645477,
-0.00008733756,
0.00667891,
-0.00048246505,
0.0018323105,
-0.00020973208,
-0.008272223,
-0.014437371,
-0.0336872,
0.005901763,
-0.016986672,
0.030253446,
-0.028640622,
-0.0071016257,
0.0054400275,
-0.023932219,
-0.007901534,
0.010405312,
-0.015126723,
0.034701716,
0.003282551,
-0.021734096,
-0.01322125,
-0.008838012,
-0.05161035,
-0.023932219,
0.0065390887,
0.0036776275,
0.004389741,
0.006952049,
-0.0071016257,
0.03402537,
-0.0138000455,
0.017506938,
-0.0048807417,
-0.0147755435,
0.017493932,
-0.021070758,
0.0038889854,
0.013156217,
-0.044378657,
-0.03189228,
0.039358094,
-0.0010104533,
-0.004305198,
0.024712617,
0.0029899015,
0.022241356,
-0.012050652,
0.013552919,
0.0027313945,
0.007888528,
0.039670255,
-0.025076803,
0.011107671,
-0.0022338906,
-0.0032223952,
-0.008649416,
0.019653033,
-0.0026468514,
0.01318223,
0.008213693,
0.019522967,
-0.023099793,
0.011959606,
-0.02101873,
0.02671564,
-0.004919762,
0.0013665102,
0.010080147,
0.022072269,
-0.0017591481,
-0.004630364,
-0.0090721315,
-0.012187222,
-0.025649095,
0.024595557,
-0.03236052,
-0.013865079,
0.006428532,
-0.018287336,
-0.01629732,
0.0035508128,
0.0045490726,
-0.028978795,
-0.023294892,
0.0011754751,
0.03914999,
0.0029395008,
-0.027470024,
-0.003719899,
-0.002697252,
-0.0024452484,
0.002172109,
-0.0136049455,
0.005309961,
-0.010073643,
0.008545362,
-0.016232288,
0.0060903593,
0.0019591253,
-0.012883077,
-0.010372796,
-0.018365376,
0.18739967,
-0.029160887,
-0.007738951,
0.0033654682,
-0.0032110144,
0.0032223952,
0.007166659,
-0.0068479963,
-0.0012413212,
0.005127868,
0.032282483,
-0.004477536,
-0.015959147,
-0.007934051,
0.005560339,
-0.009371284,
-0.02609132,
-0.0017786581,
-0.024010258,
-0.002477765,
0.021617036,
-0.0053392258,
0.02481667,
0.011406824,
0.03314092,
-0.006106618,
-0.024517518,
-0.0089225555,
0.01159542,
0.020810625,
-0.010021617,
0.016037188,
0.0012543278,
0.014255278,
0.0028191893,
0.01672654,
0.004516556,
0.008890038,
0.0116994735,
0.0024712617,
0.00296714,
-0.016895626,
-0.031033844,
0.0003871508,
0.0059830546,
0.008610396,
0.017819097,
-0.015985161,
-0.009169682,
0.028588595,
-0.035013877,
-0.005882253,
-0.011836043,
0.029030822,
0.012193725,
-0.0011250743,
0.013917105,
0.011666956,
0.016778566,
0.004812457,
-0.0098980535,
0.013878086,
-0.02397124,
0.039774306,
-0.028328463,
0.031137897,
0.0012470116,
0.016544446,
0.019757086,
-0.00660087,
0.0071471487,
0.0016591595,
0.0057261735,
0.007088619,
-0.034831785,
-0.002867964,
0.027079826,
-0.0057782,
0.028250422,
0.022865674,
-0.0043474697,
0.010164689,
-0.031996336,
0.0034597663,
-0.012993634,
-0.027209891,
0.0034857795,
0.0019331119,
-0.00025139397,
-0.028822714,
0.008155163,
-0.0058139684,
-0.003118342,
-0.01610222,
0.004870987,
-0.009800504,
-0.014320311,
-0.025727134,
-0.017467918,
-0.005605862,
-0.01796217,
0.06352443,
0.0031508587,
0.014892603,
-0.012265262,
-0.0017461415,
-0.024374444,
0.0073877717,
0.0006783776,
0.0053262194,
-0.011198717,
-0.019731073,
0.003941012,
-0.019132769,
-0.013578933,
0.03503989,
0.016128235,
-0.0017819097,
0.031528097,
-0.00642528,
0.0030549346,
-0.020355392,
0.027235905,
0.023255873,
-0.020238332,
0.022631554,
-0.01324076,
0.0037524158,
-0.002687497,
-0.041725304,
-0.020355392,
0.023906205,
-0.0027720402,
0.0038434623,
0.012544905,
0.015581955,
-0.0013274902,
-0.005358736,
-0.023698099,
0.024218364,
-0.0064057703,
-0.03027946,
0.00495553,
0.0123302955,
-0.016934646,
0.0027395235,
0.008851019,
0.022826653,
-0.026975771,
-0.008233204,
-0.0024159835,
-0.025987267,
0.005394504,
-0.0056286235,
0.012805037,
-0.005118113,
-0.0020404167,
-0.024803663,
0.02597426,
-0.03324497,
-0.044664804,
-0.0048352187,
0.01657046,
-0.026117334,
-0.0060513397,
0.0040027937,
-0.16169855,
0.015113716,
0.008005587,
-0.019119762,
0.018144263,
-0.008434806,
0.0065390887,
0.010990611,
-0.0074072815,
-0.006821983,
0.0291869,
-0.010294756,
-0.034311518,
-0.009976093,
-0.006246439,
-0.005787955,
-0.001234005,
-0.005443279,
0.0045945956,
0.016141241,
0.0040905885,
-0.02659858,
-0.011881566,
-0.01310419,
0.009963087,
0.021552004,
0.018625509,
-0.040866863,
0.0076348977,
0.00078202423,
0.011049141,
0.008272223,
0.031111883,
-0.002352576,
0.014801557,
-0.0015437256,
-0.012466865,
-0.007738951,
0.0065683536,
0.01970506,
0.019926174,
0.036522646,
-0.016947653,
0.00571967,
-0.01302615,
0.039982412,
0.010899564,
-0.0012559537,
0.028744675,
-0.00046945843,
0.030981818,
-0.0036776275,
0.017012686,
0.043780353,
0.018521456,
0.0104833525,
0.011133684,
0.012154706,
0.010964598,
0.022306388,
-0.0017087474,
-0.0028874741,
0.0262474,
-0.006448042,
-0.01807923,
-0.031346004,
0.0019558736,
0.017155759,
-0.017975178,
-0.0032971834,
-0.020225326,
-0.0033069383,
0.02129187,
-0.027157865,
0.0014079688,
0.034233477,
-0.011771009,
0.004601099,
0.002495649,
-0.0070951222,
-0.038109455,
0.016401373,
-0.02632544,
-0.024634577,
-0.02949906,
-0.0046823905,
0.0147755435,
0.023763131,
-0.013500893,
0.00286959,
0.023047768,
-0.016141241,
-0.010645935,
-0.030175406,
0.019496953,
0.032100387,
0.010828028,
0.028900756,
-0.011725486,
0.01112718,
0.04068477,
-0.03743311,
-0.017676024,
0.008811999,
0.013195237,
0.009215205,
-0.0030061598,
0.0013998396,
0.03891587,
-0.0035508128,
-0.033999357,
0.0013339935,
0.010021617,
0.025154842,
0.0016591595,
0.04677188,
0.01157591,
0.0050823446,
0.01002812,
-0.013136707,
0.059102174,
0.008681932,
0.019887153,
0.025414975,
-0.020797618,
-0.019028716,
-0.13245963,
-0.0053977557,
0.02113579,
0.03933208,
0.005134371,
0.010776002,
0.0035443094,
0.0043929927,
-0.017090725,
0.02822441,
-0.026312433,
-0.0006491126,
-0.013748019,
-0.024426471,
0.0074072815,
0.013852072,
-0.0023655826,
0.0050660865,
-0.028614609,
0.023333913,
-0.006139134,
-0.0011453973,
-0.006350492,
-0.0062724524,
-0.008252713,
0.006324479,
-0.031970322,
0.029707167,
0.0050693383,
0.01335782,
0.0051896493,
-0.014801557,
0.028276436,
0.005579849,
-0.022813648,
-0.013526906,
0.0047409204,
-0.0037524158,
0.012896084,
-0.008122647,
-0.0021656055,
-0.0057814517,
0.008662422,
-0.0044352645,
-0.017077718,
0.006626883,
-0.039176002,
-0.004383238,
0.0027427753,
-0.028692648,
-0.01660948,
-0.00996959,
-0.03621049,
-0.027079826,
0.043364137,
-0.0044840393,
0.0057001603,
0.0128700705,
-0.024088299,
0.005537577,
-0.019470941,
-0.0065195784,
-0.0064415387,
-0.004506801,
0.024140324,
0.0045685824,
-0.021630043,
-0.025727134,
0.027886236,
-0.006340737,
0.019692054,
0.00018453172,
-0.015347836,
-0.024491504,
-0.015933134,
0.014255278,
-0.0035085413,
-0.02822441,
0.0013169224,
-0.011257247,
-0.012577421,
-0.012512388,
0.012609938,
0.010210212,
0.014086192,
-0.011640944,
-0.0034565148,
-0.008746966,
0.032542616,
-0.030799724,
-0.016440393,
0.05319716,
0.044248592,
0.016596474,
-0.012102679,
0.033192948,
-0.021812135,
-0.0044612777,
0.028588595,
0.01359194,
-0.05884204,
-0.008759973,
-0.05613666,
-0.004123105,
0.0021737348,
0.022735607,
0.013513899,
-0.019809114,
-0.004181635,
0.0064643,
0.0003830862,
-0.002716762,
-0.0059830546,
0.0032354018,
-0.013722005,
-0.0063472404,
-0.022787634,
0.000046590194,
0.051584337,
0.0035378062,
0.016661506,
0.048983008,
-0.008994092,
-0.009735471,
-0.008864026,
0.019249829,
-0.00018046713,
-0.0045978473,
-0.015048683,
-0.0046368674,
-0.009358278,
0.0013031028,
0.0064708036,
-0.049113072,
-0.019614013,
0.0015640485,
-0.013761026,
-0.032620654,
-0.004432013,
0.024400458,
-0.004646622,
0.015542936,
-0.0010657316,
-0.022852667,
0.030799724,
0.013448866,
0.014216258,
-0.008753469,
-0.032074377,
0.00056782115,
0.0036776275,
-0.005596107,
0.039826334,
0.010327272,
0.01304566,
-0.011270254,
-0.014476391,
0.0074463016,
0.024634577,
-0.018456424,
0.0010454088,
-0.009676941,
0.021434944,
0.0076283948,
-0.0018290589,
-0.002191619,
-0.0019542477,
0.0013022899,
-0.03116391,
-0.0120896725,
0.016323334,
-0.021916188,
-0.022527501,
-0.0017428898,
-0.0027021295,
0.0097029535,
0.007953561,
0.020329379,
-0.043234073,
0.005865995,
-0.00415237,
0.022007236,
0.014008151,
-0.008441309,
-0.016791573,
0.024712617,
0.008311243,
-0.009585894,
-0.0016729791,
0.022800641,
0.014645477,
0.002019281,
0.007251202,
0.023307899,
0.0005271754,
0.0029134874,
0.0051798946,
0.012141699,
0.0022729104,
0.033270985,
0.0081421565,
0.018599495,
0.009046119,
-0.011888069,
0.00587575,
0.008525853,
-0.021148797,
0.015308816,
-0.024842683,
-0.03868175,
0.00087794825,
-0.005765193,
0.016167253,
-0.010229723,
0.014229265,
-0.0041751317,
-0.00083648955,
0.0034012364,
0.0033215708,
0.004958782,
-0.00662038,
0.02830245,
-0.0041783834,
0.0014274787,
0.007043096,
-0.026130341,
0.027730158,
-0.0100931525,
0.023841172,
-0.025271902,
0.01954898,
-0.021200825,
-0.0078039845,
0.011679963,
-0.0040027937,
0.00016807018,
-0.0012616441,
-0.00281106,
0.017168766,
0.030071352,
-0.0068935193,
0.088549204,
0.019796107,
-0.027391985,
0.012206732,
-0.011237738,
-0.00051051064,
0.00027232652,
0.013208243,
-0.024153331,
-0.035716236,
0.005648134,
-0.0020013968,
0.004903503,
-0.028016303,
-0.020979712,
0.0040645753,
0.0023574536,
0.009176184,
-0.020589512,
-0.0022599038,
0.010294756,
-0.03165816,
-0.0069975727,
-0.0007108942,
-0.031189924,
0.017428897,
0.029525073,
0.025232883,
-0.004227158,
-0.0262474,
-0.0043572243,
-0.016752552,
-0.027730158,
-0.013526906,
0.0160632,
-0.023008747,
-0.030383512,
-0.017936157,
-0.0016973666,
0.020797618,
0.006610625,
0.010899564,
-0.018729562,
0.0037231508,
-0.008005587,
-0.004929517,
-0.034467597,
-0.0056708953,
-0.009631417
] |
Imaging the expression of successful gene transduction has been demonstrated in vivo for the first time by using an appropriate combination of "marker gene" and "marker substrate" in an experimental animal model. The herpes simplex virus 1 thymidine kinase (HSV1-tk) gene was selected as an example of a marker gene, and the recombinant STK retrovirus containing HSV1-tk was used to transduce RG2 glioma cells in vitro and in vivo. RG2TK+ cell lines expressing the HSV1-tk gene and three potential marker substrates for the HSV1-TK enzyme were evaluated. Radiol | [
-0.034930777,
0.007553511,
-0.012795823,
-0.026817996,
-0.020281952,
-0.0014546068,
-0.0049424623,
0.00088186056,
-0.016360324,
-0.01436582,
0.01727672,
0.0026599003,
-0.01120561,
0.0058116885,
-0.011778356,
0.0033893094,
0.019931566,
-0.0019523905,
-0.011859214,
-0.016373802,
-0.04476853,
0.010194881,
0.0030035481,
-0.012047883,
-0.019729419,
0.032208547,
0.020066328,
-0.03681747,
-0.014756636,
0.010882176,
0.005606174,
-0.0021393753,
-0.016643329,
-0.015470884,
-0.013456165,
-0.019176887,
-0.00774218,
-0.003935103,
0.012714964,
-0.0046291365,
0.011717712,
0.0192847,
0.0053130626,
-0.024648298,
-0.0027306513,
-0.0016853897,
-0.00038934103,
-0.024594393,
0.003692528,
0.0040361756,
0.0062665166,
0.02467525,
-0.020133711,
0.0027491814,
-0.009467157,
0.012492604,
0.022721175,
0.0147970645,
-0.004288858,
-0.04358261,
-0.01365831,
-0.01592908,
-0.028030869,
0.01518788,
-0.008820291,
0.011374065,
-0.010444194,
-0.0024914457,
0.0016036892,
0.0012794138,
0.034041334,
-0.01641423,
-0.0022876153,
0.012074836,
0.015268738,
-0.021979975,
-0.0067213443,
0.002523452,
0.013759383,
-0.0009804067,
0.014783588,
-0.021211822,
-0.0030052327,
0.013004706,
0.0049862606,
0.004905402,
-0.00062707276,
0.024041861,
0.0029378508,
0.013045135,
0.027896106,
0.03762605,
-0.009258273,
0.029674988,
-0.025456881,
0.014284962,
0.008496857,
0.030753098,
-0.0065158294,
-0.023421947,
-0.020645814,
-0.009534539,
-0.00069656037,
-0.020093283,
-0.025429929,
0.02490435,
0.03280151,
-0.009837757,
0.011084322,
-0.015376549,
-0.026400227,
0.04406776,
-0.005043535,
-0.034230005,
0.037275665,
0.0038037081,
0.024917826,
-0.011839,
-0.0080386605,
-0.02490435,
0.0054815174,
0.009062865,
0.008530548,
-0.025416452,
0.04563102,
0.028462114,
-0.0062665166,
0.0015598909,
-0.015322643,
-0.013456165,
0.029486319,
-0.009150461,
0.027114475,
0.016575947,
-0.005791474,
0.012351102,
-0.0004135564,
-0.010653078,
-0.010322907,
-0.052288353,
0.0051580844,
0.027033618,
-0.000047614787,
0.009440204,
-0.019783325,
-0.014756636,
0.0341761,
0.004720102,
0.006259778,
0.00053526496,
0.000341542,
-0.008476643,
0.019298175,
-0.006468662,
0.01719586,
0.012276982,
-0.00010365231,
0.0034179466,
-0.006468662,
0.020605383,
0.012196124,
-0.014500584,
0.015646076,
0.030995673,
0.0158617,
0.023085037,
-0.0005542161,
0.0234489,
-0.0007075099,
-0.030726146,
-0.0056937705,
0.028030869,
-0.03878502,
0.031885114,
-0.011279729,
0.012593676,
-0.010444194,
0.0152148325,
-0.021481348,
-0.017896632,
0.0018041503,
0.015982985,
0.024176626,
0.005720723,
-0.009682778,
0.0023920573,
0.004480896,
-0.016360324,
0.014001958,
-0.009777113,
-0.0039923773,
0.021602636,
0.017290195,
-0.007897158,
-0.62746024,
-0.028893357,
-0.007829776,
-0.009810804,
0.032154642,
0.049054023,
0.026521515,
-0.016360324,
-0.03007928,
0.032478075,
-0.028165633,
0.011973763,
0.030887863,
-0.009143723,
-0.032046832,
-0.028650783,
0.0055320538,
-0.0023735273,
0.03282846,
0.020645814,
-0.017721439,
-0.01738453,
-0.008752909,
0.012876681,
0.022545982,
0.019742897,
0.021643065,
-0.027976964,
-0.008395785,
0.048514966,
-0.032505028,
0.02832735,
-0.029513272,
-0.010605911,
0.045577116,
-0.0040328065,
-0.020578431,
0.010504838,
0.0052052517,
0.040887337,
-0.0094604185,
-0.015053116,
0.017411482,
0.018098777,
-0.018732168,
0.021521779,
-0.0026582158,
0.012930586,
-0.0004628294,
-0.009494109,
-0.008436213,
0.009554753,
-0.020106759,
0.012169171,
-0.004184416,
0.0031366274,
0.0056196502,
-0.005185037,
0.020538002,
-0.010808056,
-0.0007778398,
0.006842632,
0.026400227,
-0.009150461,
-0.018381782,
0.019527273,
-0.014945305,
0.008139733,
0.01958118,
-0.0016373801,
0.02091534,
0.017263243,
-0.004834651,
0.016993714,
-0.0074524377,
0.052396163,
-0.0041069267,
-0.017505817,
0.011151704,
0.0033893094,
-0.0062260875,
-0.024729157,
-0.034068286,
0.0008666997,
0.006077847,
-0.012883419,
-0.03964751,
0.0138537185,
0.0071222666,
0.0072907214,
0.022114739,
0.023031132,
-0.028677735,
-0.018516546,
-0.03584717,
0.008901149,
0.0077219657,
0.021063581,
0.010585696,
-0.020605383,
-0.02750529,
-0.021872165,
0.013813289,
0.003972163,
0.009574967,
0.010356598,
-0.040402185,
0.014514061,
0.020861436,
-0.043340035,
-0.016009938,
-0.0029917562,
-0.008725956,
-0.0047403164,
-0.012634106,
-0.026251987,
0.045118917,
0.002609364,
0.000014266011,
-0.04611617,
0.018368306,
-0.0056668175,
-0.0049390933,
0.011481876,
0.028596878,
0.010525052,
-0.006610164,
-0.016319895,
0.03762605,
0.007897158,
0.0040226993,
-0.037275665,
0.019405987,
-0.01679157,
0.006842632,
-0.022451648,
0.0047740075,
-0.0013459534,
-0.013961529,
-0.025726408,
-0.012303934,
0.0018159421,
0.0028418314,
0.008139733,
-0.0062227184,
-0.011542519,
-0.0073378887,
-0.0035981934,
0.013894147,
-0.008813553,
0.008894411,
-0.025766838,
-0.010167928,
-0.0044202525,
0.02765353,
-0.016306419,
-0.016333371,
-0.020686243,
0.0073041976,
0.00539729,
0.006859477,
0.02773439,
-0.0045550163,
0.00793085,
-0.023664523,
-0.016589424,
0.007189648,
0.019001694,
-0.015619124,
-0.028758593,
0.0030321854,
-0.005410766,
-0.0116570685,
0.0149183525,
0.016656805,
0.003948579,
-0.008200377,
-0.027950011,
-0.008611406,
0.0021427444,
0.0046426128,
-0.02475611,
-0.005996989,
0.0056600794,
0.013678526,
0.011306683,
0.0014023858,
0.022694223,
0.020497574,
0.026602373,
-0.013813289,
0.011198872,
-0.011030417,
0.030456617,
0.00751982,
-0.0072705066,
0.022195596,
0.0053501227,
0.0021039997,
0.014055864,
0.020821007,
-0.01440625,
-0.013537023,
-0.035388973,
0.026615849,
-0.02731662,
0.006286731,
-0.0125465095,
-0.0043899305,
0.022599889,
0.027262716,
0.011670545,
-0.0078028236,
0.007540034,
0.008402523,
0.0010140976,
0.0024661773,
0.0074861287,
-0.0049390933,
-0.03732957,
-0.019271223,
0.0023128837,
0.018597404,
-0.02534907,
-0.0012128742,
0.03067224,
-0.00020635706,
-0.0023903728,
0.0125465095,
-0.022451648,
-0.005713985,
0.008517072,
0.018839978,
0.02765353,
0.025632074,
0.008166686,
0.0155113125,
-0.0060407873,
0.030726146,
0.006829155,
-0.0012971015,
0.007715227,
-0.0047099944,
-0.020794053,
0.019446416,
0.023812763,
0.018449163,
-0.007176172,
-0.031992923,
0.01485097,
-0.010343121,
0.014217581,
-0.008584454,
0.0139076235,
0.018287446,
-0.017721439,
0.019379033,
0.021090534,
0.037194807,
0.019365557,
0.008907887,
0.0006022257,
-0.005922869,
-0.019419463,
-0.004514587,
0.030214043,
-0.0052355733,
-0.02940546,
-0.016656805,
0.018327877,
-0.027532244,
0.002821617,
0.0021966498,
-0.017964015,
0.0076882746,
-0.008685526,
0.010949559,
0.022128215,
0.007984755,
0.009689516,
-0.017910108,
-0.018193113,
0.04142639,
0.000984618,
-0.006967288,
-0.031588633,
-0.03263979,
-0.024783062,
-0.008281236,
-0.0034347922,
0.025820743,
0.010538529,
0.03234331,
0.006674177,
-0.010215095,
-0.01165033,
0.02627894,
-0.0094604185,
0.0038441373,
-0.017627105,
0.010686769,
0.008287974,
-0.018193113,
-0.016009938,
0.040105704,
0.00031100956,
-0.008112781,
-0.00023773176,
-0.0032831829,
-0.009824281,
0.038353775,
-0.01332814,
-0.014015434,
-0.024769586,
-0.0030220782,
0.014662301,
-0.013179899,
0.018813025,
0.0060475254,
0.009797328,
-0.0125802,
-0.025820743,
-0.00688643,
-0.00094671565,
0.008025184,
0.017020667,
-0.0065865805,
0.00461566,
0.003695897,
0.009932091,
-0.01113149,
-0.028192585,
0.013105779,
-0.026737137,
0.00483802,
-0.000649393,
0.010956297,
-0.0004910456,
0.008328402,
0.025753362,
0.0013366884,
-0.014150199,
0.0080386605,
0.00852381,
0.0071290047,
0.011118013,
0.012755393,
0.011434708,
0.012768869,
-0.02989061,
0.03536202,
0.024634821,
0.02084796,
-0.034472577,
-0.011940072,
0.0030625071,
0.005019951,
0.0093997745,
-0.0059902505,
-0.036790516,
-0.003975532,
0.026198082,
-0.0073041976,
0.00029626978,
0.025685979,
0.04172287,
0.03007928,
0.0078028236,
-0.006653962,
-0.000861646,
-0.00893484,
-0.013186637,
-0.025605122,
-0.016629852,
0.019945042,
-0.022505553,
-0.018988218,
0.003766648,
0.0007572041,
0.0020602015,
-0.007317674,
0.0015186195,
-0.005390552,
-0.00048767647,
0.0060138344,
-0.025915077,
-0.0038913046,
-0.004261905,
-0.012297196,
-0.0005744307,
0.0041743084,
-0.009561491,
-0.02389362,
-0.019001694,
0.014150199,
-0.016481612,
-0.030348806,
-0.0010823217,
0.009541277,
0.011118013,
0.0015582064,
-0.013840241,
-0.005757783,
0.024688726,
-0.01950032,
-0.0037127426,
-0.0027508659,
-0.049054023,
-0.0029799645,
-0.0053501227,
-0.008281236,
-0.008786599,
-0.0140289115,
-0.0054141353,
0.007068361,
0.0102892155,
-0.001708131,
-0.023421947,
-0.026561944,
0.012452175,
0.020888388,
0.016104273,
-0.016171655,
0.0041001886,
-0.0019490214,
-0.032693695,
-0.016589424,
-0.028785547,
-0.029055074,
-0.0036318842,
-0.0027121215,
0.002077047,
-0.019405987,
-0.0055926973,
0.017627105,
-0.010316169,
0.015309167,
-0.0008132153,
0.033663996,
0.018880408,
0.00863836,
0.001975974,
0.00037565408,
0.0023819502,
-0.00035122814,
-0.0027272822,
0.009116771,
-0.010376812,
-0.015605647,
0.025672503,
0.021171393,
-0.010936082,
-0.011084322,
-0.0059195,
-0.017438436,
0.028758593,
-0.002575673,
-0.007573725,
-0.012047883,
-0.013543761,
-0.008442951,
0.0034230005,
0.03819206,
-0.025133448,
-0.02084796,
0.022101263,
-0.0073041976,
-0.0051008095,
-0.006458555,
-0.03625146,
-0.02144092,
0.026534991,
-0.008732694,
0.00016455923,
-0.011906382,
0.0036622062,
-0.012741917,
-0.019230794,
0.008739432,
-0.036655754,
-0.0018866932,
0.008887672,
0.030052327,
0.0278422,
0.036790516,
-0.003141681,
-0.0027609733,
0.006825786,
0.00148914,
0.012081575,
-0.0014478685,
0.024190102,
-0.032262452,
0.00017782504,
0.009312178,
-0.006536044,
0.0104105035,
0.0009745107,
0.019594656,
0.017505817,
0.0046257675,
-0.0034482686,
0.021912593,
-0.04571188,
-0.024446152,
0.024729157,
-0.02274813,
-0.0034533222,
-0.03115739,
0.0026329476,
0.032612838,
0.009662564,
0.016589424,
0.020052852,
0.030510522,
-0.0068763224,
0.008961792,
-0.011751403,
-0.009945568,
-0.016953286,
-0.0006683442,
-0.0024004802,
0.0009062865,
0.0060070963,
0.024244007,
0.0040597594,
-0.012290458,
-0.0055219466,
0.012438699,
0.013948053,
-0.028003916,
0.0019069077,
-0.0129642775,
-0.014662301,
-0.027815247,
-0.014904875,
0.00468978,
-0.029863657,
0.002221918,
0.014284962,
-0.016818522,
0.0054747793,
-0.008341879,
-0.016495088,
0.028084775,
-0.0046695657,
0.035523735,
-0.013685264,
0.022950275,
0.024446152,
0.01243196,
-0.038057297,
-0.0120680975,
-0.0037936007,
0.004403407,
0.0024324865,
0.029567176,
0.014729682,
-0.02970194,
0.033071034,
-0.0001273939,
-0.026629325,
-0.026400227,
0.020551478,
-0.0152148325,
-0.02188564,
-0.014258009,
-0.01179857,
-0.029567176,
0.020416714,
-0.005185037,
-0.0048178057,
0.0017451912,
-0.006081216,
-0.01924427,
0.024392247,
-0.00904265,
0.021225298,
-0.00703467,
-0.03253198,
-0.014648825,
-0.03390657,
-0.0042416905,
0.010686769,
0.0065596276,
0.026211558,
0.010336383,
-0.014163675,
-0.0005487413,
-0.00826102,
0.010006212,
-0.009022436,
-0.004511218,
0.036871374,
-0.0070548845,
0.0026935914,
0.015322643,
-0.0011438077,
-0.011495352,
-0.0029429044,
0.0024324865,
-0.013745907,
-0.025888124,
0.00796454,
0.029459365,
0.026804518,
-0.0093458695,
-0.0046358746,
-0.013011444,
-0.0034903823,
-0.018193113,
-0.031373013,
0.017977491,
-0.051506724,
0.0121287415,
-0.007391794,
0.014150199,
0.004339394,
0.021804782,
0.008328402,
0.020538002,
0.056115646,
-0.013840241,
0.010605911,
0.009244796,
0.0077623944,
-0.017559722,
0.0075872014,
-0.0056870324,
-0.038245965,
0.015753888,
-0.020052852,
-0.021265727,
-0.034634296,
-0.003138312,
0.00081447867,
0.020591907,
-0.009527801,
0.0137324305,
-0.007701751,
0.024244007,
0.008759647,
-0.00766806,
0.009534539,
-0.019042125,
0.01485097,
-0.00016634905,
-0.027896106,
0.0036116696,
-0.012741917,
-0.008517072,
-0.020497574,
-0.026157653,
-0.020093283,
-0.01954075,
0.025214305,
-0.016198609,
0.020726671,
0.0026447396,
-0.015443931,
-0.023987956,
-0.0007677325,
0.017249765,
-0.020605383,
-0.0076141544,
0.009884925,
-0.014217581,
0.01436582,
-0.018988218,
-0.004127141,
0.005781367,
-0.021939546,
-0.018920837,
0.0054175043,
-0.0032478075,
0.020982724,
-0.0008111096,
-0.029836705,
-0.021710448,
-0.017330624,
-0.0498087,
-0.011670545,
0.0068999063,
-0.012472389,
0.01157621,
0.030914815,
-0.024190102,
-0.005016582,
-0.021009676,
0.031696446,
0.01313947,
-0.0069807647,
0.024527011,
0.011481876,
0.003911519,
0.04169592,
-0.027788294,
-0.016616376,
0.031076532,
-0.007492867,
-0.005552268,
0.034930777,
-0.044040807,
0.045577116,
-0.016009938,
0.016980238,
0.0040496523,
0.019069077,
0.014729682,
-0.031992923,
-0.0104981,
0.022424696,
0.0011016941,
-0.0053096935,
0.003409524,
-0.007533296,
0.01760015,
0.015107022,
-0.012735179,
-0.006118276,
0.008712479,
0.008173424,
0.023502806,
0.025605122,
-0.0018041503,
0.012223076,
0.0009930407,
-0.0076613217,
0.019446416,
0.0030220782,
-0.0278422,
-0.014756636,
-0.005575852,
-0.00095008477,
0.014190627,
0.009049389,
0.023704952,
-0.013894147,
-0.0005575852,
0.032046832,
-0.023071561,
-0.022802034,
0.019783325,
-0.0015287268,
-0.027262716,
-0.011306683,
0.0036453607,
-0.011555996,
-0.03037576,
-0.016009938,
0.006317053,
0.018004443,
-0.0011968709,
-0.011441446,
0.0023819502,
0.007748918,
-0.015834745,
-0.012977754,
-0.032100737,
-0.0027390742,
0.19524579,
-0.009905139,
0.0040732357,
0.013826765,
0.008092565,
-0.0012650951,
0.03067224,
0.016535517,
0.014231057,
0.0071559576,
0.029540224,
0.0011362273,
-0.00830145,
-0.014109769,
0.010140976,
-0.0059902505,
-0.009258273,
-0.019864183,
-0.023192849,
-0.015726935,
0.004194523,
-0.0012482497,
0.011286468,
-0.013611143,
0.01901517,
0.007418747,
-0.005222097,
0.014244533,
0.0137324305,
-0.0042450596,
-0.034068286,
0.0010705299,
0.010680031,
0.0052389423,
0.0031501036,
0.0026262095,
-0.00039923773,
0.007728704,
0.015255261,
0.004969415,
0.010963035,
-0.014123246,
-0.016535517,
-0.000114759794,
-0.00034238427,
0.018139206,
-0.006286731,
0.0013703794,
-0.006246302,
-0.027127951,
-0.03848854,
-0.0062732548,
0.00398227,
0.0038778281,
-0.004693149,
0.0139211,
0.024122719,
0.014001958,
0.013334878,
0.03428391,
-0.01470273,
0.015996462,
-0.04455291,
0.034930777,
-0.008159948,
0.030699192,
-0.012775607,
0.002162959,
0.022276456,
-0.009386298,
0.019971995,
-0.00093071244,
-0.0077893473,
0.025119971,
0.0070548845,
-0.0029462734,
0.0074591762,
0.009339131,
0.028057823,
0.00307093,
0.002248871,
0.005727461,
-0.02724924,
0.0006578158,
-0.016912857,
-0.01704762,
0.014972257,
0.014001958,
0.0011412809,
0.021831734,
0.004713364,
-0.0056600794,
-0.0010553689,
-0.0014655562,
-0.007209863,
0.0051446077,
-0.000993883,
0.012364578,
0.019163411,
-0.027006665,
-0.050374705,
0.053501226,
0.024985207,
-0.010208357,
0.0007748918,
0.023880145,
-0.00703467,
0.001760352,
0.015093545,
-0.03654794,
0.017290195,
-0.027195334,
0.0025183985,
-0.0023920573,
0.001403228,
0.02389362,
0.0115964245,
-0.023556711,
0.025591645,
0.016198609,
0.0026733768,
0.002535244,
-0.017573198,
0.014648825,
-0.017667534,
-0.0049795224,
-0.024136195,
-0.012182647,
-0.022653794,
-0.030807003,
0.009777113,
0.0038205537,
-0.0029024752,
0.011043893,
0.0033994168,
-0.03212769,
0.0119535485,
0.0147431595,
-0.04746381,
0.010033164,
-0.0049121403,
-0.0074861287,
-0.0004914667,
0.0044202525,
0.016077321,
-0.02524126,
-0.008079089,
0.021279203,
-0.01291711,
-0.0062631476,
-0.011360588,
-0.012896895,
-0.008483381,
-0.009952306,
0.005606174,
-0.03673661,
-0.03587412,
-0.024580916,
0.015996462,
0.0046358746,
-0.025915077,
0.0146218715,
0.017074572,
-0.0112999445,
-0.015241785,
-0.0055286847,
-0.17055705,
0.0020248261,
0.010248787,
-0.033259705,
0.011111275,
0.019190364,
0.018624356,
-0.00837557,
-0.007728704,
0.027707437,
0.017451912,
0.006987503,
-0.04972784,
-0.03145387,
-0.0059835124,
0.008752909,
-0.018718692,
0.02617113,
0.032100737,
0.0061890273,
0.030833956,
-0.004797591,
0.02125225,
-0.010915867,
-0.0042012613,
0.0016239038,
-0.005370337,
-0.024109242,
-0.012634106,
-0.022316884,
-0.0129508,
0.023947526,
0.008422737,
-0.011663807,
-0.003695897,
-0.0129642775,
0.0042787506,
0.0058858087,
0.0047605312,
0.014891399,
0.018516546,
0.032073785,
-0.0002448911,
-0.016737664,
-0.017694486,
0.009905139,
-0.00084480055,
-0.015416978,
0.0040631285,
0.006306946,
0.023233278,
-0.009244796,
0.010740674,
0.013011444,
0.03751824,
-0.011973763,
-0.012762131,
0.0012423537,
0.014500584,
0.0022808772,
0.00048725534,
-0.015174403,
0.018705215,
-0.016198609,
0.0010376812,
-0.035119444,
-0.020578431,
-0.019459892,
-0.016575947,
0.0001994083,
-0.018220065,
-0.002609364,
-0.00062707276,
-0.015012687,
0.006852739,
0.00035501836,
-0.011960287,
0.014109769,
-0.01514745,
-0.023071561,
-0.0009197629,
0.027923059,
-0.01514745,
-0.0063642203,
-0.004113665,
0.013159685,
0.026588896,
0.023435423,
0.009123509,
-0.00026447396,
0.009265011,
-0.02579379,
0.0025925185,
-0.007566987,
0.026831472,
0.02207431,
0.0044573126,
0.00554553,
0.016562471,
-0.0069133826,
0.018961266,
-0.010302692,
-0.0053029554,
0.0020046115,
0.03975532,
-0.0017856202,
-0.012276982,
0.031130437,
0.039997894,
0.029324602,
-0.0356585,
-0.00025015528,
0.009278487,
0.031777304,
-0.011279729,
0.03487687,
-0.019675514,
0.008766385,
0.013429212,
-0.021090534,
0.055792212,
0.009116771,
-0.0029243743,
0.008840505,
-0.0034937514,
-0.01299123,
-0.112123474,
-0.0259016,
-0.009386298,
-0.015740411,
0.011616639,
0.022451648,
-0.0022977227,
0.00070919446,
-0.022492077,
0.024311388,
-0.043798234,
-0.007553511,
-0.017411482,
-0.018934313,
0.004696518,
0.0067617735,
0.017249765,
0.0073715798,
-0.02873164,
0.016360324,
0.002590834,
-0.01224329,
-0.0006898222,
0.003766648,
0.00031100956,
0.006967288,
-0.030753098,
0.02374538,
0.019891135,
0.015956033,
0.008025184,
-0.0053400155,
0.020403238,
-0.011043893,
-0.022465125,
-0.009130247,
-0.026534991,
-0.01719586,
0.002597572,
-0.013368568,
0.014338868,
0.012337625,
0.006600057,
0.008941578,
0.0046122908,
0.008800075,
-0.015794316,
-0.011185395,
-0.012479127,
-0.0036116696,
-0.03290932,
-0.018853456,
-0.03546983,
-0.00472684,
0.032181595,
-0.019648561,
0.025376022,
0.0048885564,
-0.0027087522,
-0.019554226,
-0.0010949558,
-0.00863836,
0.00062580936,
0.012499342,
-0.008476643,
-0.005889178,
-0.025119971,
-0.025739884,
0.03037576,
-0.01842221,
-0.0033438266,
-0.001954075,
-0.008052137,
-0.007553511,
-0.021912593,
0.011475137,
-0.03145387,
-0.018368306,
0.009197629,
-0.0067247134,
-0.009312178,
-0.022788558,
0.04549626,
-0.029944515,
0.03692528,
0.012371317,
-0.0028367778,
-0.016090797,
0.00065276213,
-0.015322643,
-0.012270244,
0.04112991,
-0.012647582,
-0.012263506,
-0.018543499,
0.021629589,
-0.012890157,
0.03517335,
0.021616112,
0.010208357,
-0.012020931,
-0.02627894,
-0.060320273,
0.00054368767,
0.015902128,
-0.019527273,
0.0042046304,
-0.017478865,
-0.01652204,
0.012378055,
0.007533296,
-0.019190364,
-0.017101526,
-0.0065933187,
-0.03193902,
0.012074836,
-0.007856729,
-0.010659816,
0.029243743,
-0.0058116885,
0.025942031,
0.029755846,
-0.0013543761,
-0.01172445,
-0.024661774,
0.01578084,
0.0067685116,
0.005717354,
0.0022724546,
0.039351027,
-0.016131226,
-0.024594393,
0.0112999445,
-0.030402713,
-0.0049660457,
0.0015118814,
0.015174403,
0.0008250071,
0.017559722,
0.018866932,
0.022936799,
0.04280098,
-0.024729157,
-0.041857634,
0.019379033,
-0.0004002906,
-0.023502806,
0.018260494,
-0.033556186,
0.0038879355,
0.0024729157,
-0.0046729348,
0.017775344,
0.005070488,
-0.010605911,
-0.0037733864,
-0.0134359505,
-0.0021107378,
0.0032208548,
-0.01842221,
0.0050974404,
0.0026295786,
0.014985734,
0.011333635,
-0.0039991154,
0.009157199,
0.016306419,
-0.024405723,
-0.026117224,
-0.014042388,
0.010154452,
-0.04220802,
-0.042234972,
0.020821007,
0.009035912,
0.017061096,
0.0025857803,
-0.003931734,
-0.013988482,
-0.017034143,
-0.0034667987,
0.015848223,
0.01793706,
-0.018327877,
0.0016373801,
0.023839716,
0.02467525,
0.018624356,
0.005505101,
0.036197554,
0.004511218,
0.008907887,
0.005387183,
0.016104273,
0.015942557,
0.0074861287,
0.004265274,
0.014675777,
-0.0027660269,
0.014015434,
-0.00047504238,
0.044013854,
0.0061856583,
0.0069740266,
0.01909603,
-0.019122982,
-0.020713195,
0.050967667,
-0.049673934,
-0.028704688,
-0.022882892,
-0.0047672694,
0.0034937514,
0.0014065971,
-0.001572525,
0.004851497,
-0.01924427,
-0.006889799,
-0.0030321854,
-0.026454132,
-0.009372822,
0.045361493,
0.007823038,
0.0069201207,
0.012169171,
0.0011000094,
0.01901517,
-0.0006898222,
0.0147431595,
-0.020133711,
0.010558743,
-0.0312652,
-0.0011118014,
0.025322117,
-0.0079173725,
-0.022438172,
-0.009851233,
-0.021238774,
0.008611406,
0.014204104,
-0.021171393,
0.092555776,
0.02133311,
-0.007836515,
0.0058858087,
-0.027437909,
0.016670281,
0.021292679,
0.0015085122,
-0.018260494,
-0.028947264,
0.014096293,
-0.018152684,
0.05449848,
-0.025524262,
-0.023421947,
0.0015885283,
0.008442951,
0.011481876,
-0.023206325,
-0.017546246,
0.0073109358,
-0.018098777,
0.026454132,
0.011259515,
-0.011569472,
-0.009433466,
0.004470789,
-0.022155168,
-0.0014672409,
-0.020187616,
0.003837399,
-0.01213548,
-0.043420896,
-0.01440625,
-0.005781367,
-0.008557501,
-0.013665048,
-0.0027407587,
0.027518766,
0.013449427,
0.022586413,
-0.023651047,
-0.004086712,
-0.02486392,
0.002686853,
-0.0019186995,
-0.03350228,
-0.012856466,
0.008220592
] |
The clearance of apoptotic cells by phagocytes is an integral component of normal life, and defects in this process can have significant implications for self tolerance and autoimmunity. Recent studies have provided new insights into the engulfment process, including how phagocytes seek apoptotic cells, how they recognize and ingest these targets and how they maintain cellular homeostasis after the 'meal'. Several new factors that regulate engulfment have been identified, whereas the roles of some of the older players require revision. This Review focuses on these recent developments and attempts to highlight some of the important questions in this field. | [
-0.007165753,
0.0125598265,
0.0086542275,
-0.01475302,
-0.021773878,
0.019007687,
-0.005423711,
0.008693744,
-0.011479694,
-0.007014271,
0.032562025,
-0.016478598,
0.0086739855,
0.010649837,
0.002364435,
-0.009464326,
0.04283645,
0.008482987,
-0.02803074,
0.0021536776,
-0.019969268,
0.035354562,
0.001117179,
-0.011585073,
-0.015358948,
0.005222833,
0.012968169,
-0.035644352,
0.001344402,
-0.015135018,
0.0031136118,
-0.038252477,
-0.014621297,
-0.0074950615,
-0.0040472015,
-0.014924261,
0.020364437,
-0.019956095,
0.03079693,
0.0011986829,
0.011512625,
0.00041513453,
-0.010136115,
0.009978048,
-0.0069154785,
-0.009648739,
-0.022893528,
-0.014476402,
-0.020957192,
0.008127334,
0.028847424,
-0.010063668,
-0.021352364,
-0.0052195396,
-0.0062897922,
-0.0052557634,
-0.025145996,
0.026884746,
0.0033177831,
-0.028478598,
0.0059209666,
-0.015582878,
-0.0072579593,
0.006467619,
0.0044028545,
0.013936335,
0.0012571352,
0.014265644,
0.0025636666,
-0.002184962,
0.047104288,
0.005031834,
-0.0020647643,
0.027082331,
0.020496162,
-0.019231616,
-0.012401758,
0.0070801326,
-0.020693745,
0.006194293,
0.0057892436,
-0.021905601,
0.006207465,
0.04639298,
0.017400661,
0.01688694,
-0.01260593,
-0.00009292674,
0.017137215,
0.0031728875,
0.01604391,
-0.004850714,
0.021866085,
0.026357852,
-0.011209661,
0.018968169,
0.0005466521,
0.027793637,
0.008502745,
-0.038884748,
-0.016307358,
0.006856203,
-0.0026690455,
-0.010498355,
-0.02527772,
-0.0064050504,
0.011762899,
0.00069525256,
0.008970363,
0.01953458,
-0.0005618826,
0.028399564,
-0.0007150111,
-0.038805712,
0.028715702,
0.010004392,
0.018019762,
0.010748629,
-0.034722287,
-0.0060724486,
0.008252471,
0.016070254,
0.029848522,
-0.013073548,
0.010392976,
0.008180023,
-0.0074555445,
-0.00015209937,
-0.015951704,
-0.013363339,
-0.0008965424,
0.028478598,
0.0019297478,
0.00534797,
-0.021589465,
0.0065334807,
-0.010913284,
0.014226127,
0.003566411,
-0.020403955,
0.028452255,
0.03659276,
0.0004704995,
-0.01320527,
0.011156972,
0.005041713,
0.042573,
0.028557632,
-0.023894625,
0.020351265,
-0.008180023,
-0.012862789,
0.017189903,
-0.021866085,
0.015912186,
-0.0019593856,
-0.0031267842,
0.016742043,
-0.018164657,
-0.016689355,
-0.009708014,
-0.005779364,
0.005818881,
0.00406696,
0.016386392,
0.0077848528,
-0.002306806,
0.021997808,
0.002012075,
-0.016807906,
0.002267289,
0.024605932,
-0.0026772781,
0.008153679,
-0.025633374,
0.009635567,
0.015135018,
0.03129748,
-0.02201098,
-0.0052524707,
0.013304063,
0.032403957,
0.0198112,
0.0033210763,
-0.0066783763,
0.008153679,
0.020575196,
-0.007488475,
-0.00043551048,
-0.0036915482,
0.0008701977,
0.025185514,
-0.002832053,
-0.024698138,
-0.6436532,
-0.024961583,
0.05184633,
-0.009102087,
-0.00875302,
0.023459937,
0.0040340293,
-0.038805712,
-0.0024813395,
0.01263886,
-0.017637763,
0.023288697,
0.016281012,
-0.010531286,
-0.027609223,
-0.027925361,
-0.0043073553,
-0.02037761,
0.022037325,
-0.008482987,
-0.0000027785404,
-0.0068891337,
-0.030875964,
0.012974755,
-0.0032585075,
0.021721188,
0.016979147,
-0.018256864,
-0.0071855113,
0.03733041,
-0.016873768,
0.0072579593,
-0.013593854,
0.02787267,
0.05774754,
0.020785952,
-0.0078111975,
0.02606806,
-0.008456642,
0.041835353,
-0.01061032,
-0.008621297,
0.024948413,
0.0016078487,
-0.012184414,
0.01246762,
0.0070801326,
0.0048342487,
0.0067146,
-0.012757411,
0.012981341,
0.02768826,
-0.009747531,
0.00858178,
0.017466523,
0.008957191,
0.032298576,
-0.016504942,
0.022774976,
-0.008976949,
0.0050515924,
-0.001860593,
-0.0052458844,
-0.031850718,
-0.031718995,
0.036513727,
-0.01688694,
0.004416027,
0.007989024,
0.0019099893,
0.007679474,
0.010926456,
-0.019416029,
0.022392977,
0.005581779,
0.016215151,
-0.00808123,
0.0075411648,
0.011242592,
0.008825468,
-0.014278816,
-0.0051240404,
-0.006783755,
0.0040142704,
0.010748629,
0.011459935,
-0.009931944,
0.0021355655,
-0.002573546,
0.004182218,
-0.005512624,
-0.015003295,
-0.004458837,
-0.043152586,
-0.020812297,
0.029822178,
-0.0222876,
-0.016768388,
-0.0031086723,
-0.01232931,
0.0084105395,
-0.021681672,
-0.0041723386,
0.011664107,
0.035618007,
0.014911089,
-0.031113068,
-0.020245887,
0.057167955,
-0.024289794,
0.015319431,
0.0006067509,
0.0076070265,
-0.011150386,
-0.0022755216,
-0.014291989,
0.0068101,
0.028952803,
-0.002288694,
-0.027635569,
0.0146344695,
-0.00667179,
0.011618004,
-0.020746436,
0.012276621,
0.023618005,
0.012171242,
-0.018678378,
-0.011137214,
-0.01817783,
-0.0018655326,
-0.03174534,
-0.0035137217,
-0.00477168,
0.0088781575,
0.01325796,
0.0051635574,
-0.019139409,
0.015754119,
-0.030612517,
-0.026450058,
-0.012500551,
0.01688694,
0.0012908893,
0.0022541166,
-0.0015642154,
-0.009339189,
-0.0027628983,
0.008068059,
0.0011147093,
0.010142702,
0.009754118,
-0.016873768,
0.00402415,
0.01717673,
0.008542262,
-0.01339627,
-0.005538969,
-0.016926456,
-0.0053578494,
-0.003530187,
0.028004395,
-0.0024895722,
0.01925796,
-0.007929749,
-0.01502964,
0.01224369,
-0.00061992323,
-0.010142702,
-0.03293085,
0.009214052,
0.0005351263,
-0.018507138,
0.017400661,
0.003645445,
0.008318333,
-0.010287598,
-0.007936335,
0.015477499,
-0.00059646,
0.027187709,
-0.027108675,
-0.005585072,
0.0020779367,
0.0032832057,
0.011045007,
0.030691551,
0.0141866105,
0.0074291998,
0.035881452,
0.0043633375,
0.01184852,
-0.028215151,
0.006974754,
-0.009095501,
-0.010109771,
-0.0016975853,
0.017848521,
0.012052691,
0.038700335,
0.009622394,
-0.0321932,
0.005650934,
-0.01007684,
0.015398465,
-0.0038924264,
0.0015568059,
-0.015833152,
0.016149288,
0.012316138,
-0.011466522,
-0.005723382,
-0.0019313943,
-0.010050495,
0.0026904505,
0.01475302,
0.0130472025,
-0.0047881454,
-0.022524701,
-0.012059277,
0.021009883,
-0.018414931,
0.014937433,
-0.037989028,
0.005611417,
0.032114163,
0.039095506,
0.027556535,
-0.0102612525,
-0.01055763,
0.0050087823,
-0.0073172348,
-0.004149287,
0.012592757,
0.005394073,
0.011578487,
0.0013345227,
0.005664106,
0.020733263,
-0.002840286,
-0.012223931,
0.014568608,
-0.0047222837,
0.0040340293,
-0.025989026,
-0.0049692653,
0.018928653,
0.0153457755,
-0.018230518,
-0.008957191,
-0.0037903409,
0.008140506,
-0.018270036,
0.011321627,
-0.0044720094,
-0.001972558,
0.00300494,
0.00027456097,
0.03258837,
0.007830956,
0.020680573,
-0.022419322,
-0.01661032,
-0.011953899,
0.023209663,
-0.010043909,
0.021326018,
-0.032614715,
-0.014726676,
-0.012052691,
-0.036487382,
-0.028557632,
0.00030955,
-0.021023054,
0.031560928,
0.027372122,
0.010623492,
-0.007139408,
0.015530189,
-0.005812295,
-0.040649842,
-0.022867182,
0.026265645,
0.040965978,
-0.00923381,
-0.0033161365,
-0.01812514,
-0.008456642,
-0.0066816695,
0.008680572,
0.0014028542,
0.013778267,
-0.0067574102,
0.0026492868,
-0.029242594,
0.008166851,
0.02656861,
0.00016979969,
0.018783757,
-0.00976729,
0.005766192,
-0.024302967,
-0.008094403,
0.02274863,
0.014423712,
0.019837543,
0.016017566,
-0.009866083,
-0.012065863,
-0.025699235,
-0.02054885,
-0.006948409,
0.018309552,
-0.009378706,
-0.0121119665,
-0.009839738,
-0.017084524,
0.01829638,
0.012935238,
-0.008548848,
-0.0016243141,
-0.013778267,
0.018019762,
-0.021023054,
0.04165094,
0.02324918,
0.00070183876,
0.024197588,
0.000265505,
-0.0054500555,
-0.0009335896,
-0.0069813402,
0.04249397,
0.00066396827,
-0.028346876,
0.013501649,
-0.0044456646,
0.0054829866,
0.02916356,
0.024065865,
0.008845226,
-0.02020637,
-0.020351265,
-0.013244788,
0.003997805,
-0.026384197,
0.027161365,
0.024908895,
0.02302525,
0.0052886945,
0.022603735,
0.0065664113,
-0.0072184424,
0.00028505767,
0.009490671,
0.025936337,
0.017874865,
0.0022738753,
-0.018678378,
-0.011532384,
0.01100549,
0.0111438,
0.004001098,
-0.005736554,
0.012250276,
0.022340288,
-0.0009714601,
-0.008739848,
0.0020861693,
0.005268936,
0.022392977,
0.044785954,
-0.01179583,
-0.00068701984,
0.04070253,
-0.03169265,
-0.008812295,
-0.028847424,
0.014199782,
-0.010656423,
0.005762899,
-0.0008076291,
0.008153679,
-0.0062239305,
0.011749728,
-0.015978048,
-0.01475302,
-0.006391878,
-0.014924261,
-0.013409442,
-0.008660814,
-0.012849618,
-0.024382,
-0.0009039518,
0.029532386,
-0.027819982,
-0.008318333,
-0.0030082332,
0.011453349,
0.012059277,
0.018019762,
-0.0136992335,
-0.0014341385,
0.0188101,
0.01834907,
0.0035038425,
0.006108673,
-0.033299677,
0.019863889,
0.016913284,
-0.0060955,
-0.02505379,
-0.013277719,
0.010392976,
0.009200879,
-0.0014950606,
0.003530187,
0.030717896,
-0.019139409,
0.0070274435,
0.004537871,
0.020641057,
-0.011084524,
0.0021569706,
-0.01320527,
-0.016504942,
-0.0144105395,
-0.015661912,
-0.010577389,
-0.015451155,
0.0033622398,
0.010551045,
0.000790752,
-0.013989025,
0.011124041,
-0.013580683,
-0.010063668,
-0.008726675,
0.005851812,
0.028689357,
0.009740945,
0.04304721,
0.013883647,
0.0032980246,
-0.028004395,
-0.026502747,
0.010906697,
0.008140506,
-0.006158069,
-0.02211636,
-0.028557632,
-0.0015246983,
-0.010182219,
-0.007139408,
-0.015385293,
0.015095501,
0.020351265,
-0.015859498,
-0.023038423,
0.002382547,
0.01055763,
0.024461035,
0.008041713,
-0.020733263,
0.009490671,
-0.00015796517,
-0.010221736,
-0.011736555,
0.023354558,
-0.040281016,
0.012250276,
0.03232492,
0.0065400666,
0.022300772,
-0.017242594,
-0.014937433,
-0.020838642,
0.01210538,
-0.03817344,
-0.03482767,
-0.01581998,
-0.0065301876,
0.06522943,
0.03519649,
0.0037903409,
-0.006398464,
0.014568608,
0.001860593,
-0.000455269,
-0.010294184,
0.0010727225,
0.009075742,
-0.009075742,
0.02768826,
-0.008291988,
-0.0067574102,
-0.0009418223,
-0.0072579593,
0.0038957195,
-0.00014232301,
-0.0032700333,
-0.0272404,
-0.013317236,
-0.024843033,
-0.029005492,
0.023077939,
-0.014371023,
0.0070340293,
-0.014713503,
-0.002673985,
0.019416029,
0.025817785,
-0.0073369932,
-0.00392865,
0.017519211,
-0.030770587,
-0.0052919877,
-0.0046663014,
0.0014119102,
-0.006118552,
-0.022366634,
-0.0073435795,
-0.009088915,
0.01616246,
0.018414931,
-0.0064972565,
0.011960485,
-0.022261254,
-0.0040900116,
0.008779365,
-0.009490671,
-0.04165094,
-0.00844347,
-0.029874867,
-0.031850718,
0.006665204,
-0.007330407,
-0.017097697,
-0.020878159,
0.010333701,
-0.015978048,
0.0039253575,
0.0073369932,
-0.027556535,
0.024052693,
0.0039747534,
0.015517016,
-0.013857301,
0.020957192,
0.01699232,
-0.005272229,
-0.037593856,
0.0031399566,
-0.0045971465,
0.02218222,
0.021879256,
0.033615813,
-0.015978048,
-0.021628981,
-0.0057102093,
-0.000649561,
-0.0116443485,
-0.029874867,
0.017743142,
0.011492867,
0.013336994,
-0.0041624596,
-0.011973657,
-0.029110871,
0.0002517152,
0.0040570805,
0.007837542,
-0.0010875413,
-0.0043271137,
-0.033800226,
0.025817785,
0.00081627344,
-0.010965973,
0.014924261,
-0.0216685,
-0.002853458,
-0.02753019,
-0.0088781575,
0.006796927,
0.0015864437,
0.005818881,
-0.0010636664,
0.009925358,
0.013350166,
0.010234908,
0.0066882554,
-0.010735457,
-0.007745336,
0.030533483,
-0.00024636392,
-0.006625687,
-0.0009829858,
0.008423711,
-0.0047354563,
-0.01863886,
-0.004837542,
-0.00022886941,
-0.004564216,
-0.009352362,
0.016821079,
0.015490672,
-0.01334358,
-0.016201979,
-0.016254667,
-0.0118682785,
-0.013712406,
-0.020970365,
0.0139626805,
-0.0029127337,
-0.0022738753,
0.014713503,
0.01570143,
0.008265643,
0.010564216,
0.012592757,
-0.036724485,
0.03783096,
-0.009787048,
0.02122064,
0.0030000005,
0.0058649844,
0.0044720094,
-0.0024368828,
-0.01184852,
-0.031956095,
-0.0005845226,
0.004880352,
-0.034037326,
-0.004524699,
-0.0077848528,
0.03511746,
-0.0060625696,
-0.017545557,
0.006329309,
0.016057082,
0.019850716,
0.0067574102,
-0.015464327,
0.019047204,
-0.036382005,
-0.007870473,
0.014397368,
-0.010854008,
-0.0051372126,
0.017795831,
-0.021246985,
0.0060889143,
-0.0013411088,
-0.029980246,
-0.02787267,
-0.0065301876,
-0.021655327,
-0.004798025,
-0.01755873,
-0.0009377059,
0.0047947317,
-0.004027443,
0.002191548,
-0.013132823,
-0.0052886945,
0.0004540341,
-0.002904501,
0.015754119,
-0.0107091125,
0.0014102636,
0.004175632,
-0.027451156,
-0.009227224,
-0.007020857,
-0.019336995,
0.016768388,
0.0028007687,
0.0020746435,
-0.00799561,
0.019297479,
-0.04075522,
-0.021918774,
-0.008068059,
0.007047202,
-0.0052985735,
-0.00006905188,
-0.010399562,
0.0008636115,
-0.0039055988,
0.021036226,
0.00009431601,
-0.030744242,
0.0057266746,
-0.0076136123,
0.009530188,
-0.01241493,
-0.017861692,
-0.008812295,
0.018836446,
-0.014147093,
-0.012401758,
0.010281011,
0.0068364446,
0.020311749,
-0.0071920976,
-0.0037607031,
0.006987926,
0.011051593,
0.020114163,
0.0070735463,
-0.0020894625,
0.027846327,
-0.02077278,
-0.030586174,
-0.01772997,
0.024461035,
0.0018177829,
-0.0032568611,
-0.02533041,
-0.035591662,
0.004080132,
-0.016900113,
0.03224589,
0.023538971,
-0.026871573,
0.016057082,
-0.007989024,
-0.017703624,
-0.024408346,
-0.0033227226,
-0.005048299,
0.008094403,
-0.011558728,
0.00437651,
0.003688255,
-0.014094404,
0.008403953,
-0.034801323,
-0.007896818,
-0.024342485,
0.018783757,
-0.03351043,
0.016926456,
0.010043909,
-0.001499177,
0.007350166,
-0.0018391879,
-0.017203076,
-0.018902307,
0.012922065,
-0.012849618,
-0.016939629,
0.0060197595,
-0.0028732168,
0.0070801326,
-0.009108673,
-0.016149288,
-0.015108674,
-0.013422614,
0.021536775,
0.18504503,
-0.042046107,
0.010860594,
0.002688804,
-0.027398467,
-0.020706918,
-0.0026114164,
-0.017795831,
-0.008226126,
0.01564874,
0.013066961,
-0.003335895,
-0.016188806,
-0.0019511528,
0.010030737,
-0.020114163,
-0.03619759,
-0.010755216,
-0.017018663,
0.00087678386,
0.014054887,
-0.03232492,
0.012625688,
0.012125139,
0.047657527,
-0.0037047206,
-0.006563118,
0.02010099,
0.00023771958,
0.0057266746,
-0.02223491,
-0.0007294183,
0.012889135,
0.020390783,
0.00061210216,
0.021207467,
-0.024605932,
-0.014950606,
0.026871573,
-0.011242592,
-0.013053789,
-0.028636666,
0.010294184,
0.0052327123,
0.0013090012,
0.039833155,
-0.0058715707,
-0.019600442,
0.0058353464,
0.0029473111,
-0.058854014,
0.00269539,
-0.003368826,
0.015161363,
0.013066961,
0.004936334,
-0.0025702529,
-0.0011739848,
0.011183317,
0.018691551,
-0.009754118,
-0.0032288698,
-0.029637765,
0.030375415,
-0.0002671515,
0.014463229,
-0.011683865,
-0.017018663,
0.017888037,
-0.032509334,
0.02139188,
0.00561471,
-0.021642154,
-0.029743144,
-0.0061416035,
-0.0059637767,
-0.006783755,
0.00043880357,
0.014252472,
0.013145995,
-0.008930846,
0.01475302,
-0.028952803,
-0.0029818884,
0.0039813397,
-0.0314292,
0.02567289,
0.010149288,
-0.012731067,
-0.017888037,
0.0015609222,
0.0059934147,
0.00074917683,
0.006563118,
0.011045007,
-0.007389683,
0.021023054,
0.026937434,
-0.013159168,
-0.01184852,
-0.020430299,
0.07339628,
0.009806807,
0.0086739855,
-0.024645448,
0.010419321,
-0.025857303,
0.022419322,
0.0017864986,
-0.020298576,
0.013001099,
-0.021997808,
0.005917674,
-0.0049528,
-0.0004968442,
0.03040176,
-0.014990123,
-0.01762459,
0.025989026,
-0.008173437,
-0.020812297,
-0.033879258,
0.01581998,
0.022524701,
0.008588365,
-0.0038265646,
-0.03635566,
0.010827663,
-0.008021955,
-0.027477501,
-0.016083427,
0.008812295,
-0.013178926,
0.03040176,
0.004264545,
0.0036026349,
-0.010873767,
-0.0052755224,
-0.022985734,
0.02127333,
-0.02527772,
-0.00827223,
0.0066915485,
0.023038423,
-0.008884743,
0.0027019763,
0.018836446,
0.029874867,
-0.026911091,
-0.0028172343,
-0.018994514,
-0.011407247,
-0.02364435,
-0.010175632,
0.012744239,
-0.035591662,
-0.003350714,
-0.011953899,
0.0067508244,
-0.018256864,
-0.0346696,
0.009780463,
0.0054500555,
-0.010656423,
-0.021549948,
-0.0212865,
-0.16449618,
0.0053150393,
-0.010847422,
-0.00951043,
0.03822613,
0.0061152587,
-0.03084962,
0.01252031,
-0.026924262,
-0.005960484,
0.050924268,
-0.01790121,
-0.04634029,
-0.030691551,
0.0073962687,
-0.023710212,
0.015978048,
0.034458842,
-0.00095581793,
0.024684966,
0.031455547,
-0.023407249,
0.01626784,
0.009161362,
-0.0074555445,
0.017361144,
0.015240397,
-0.008812295,
0.009826565,
-0.0018194295,
-0.018335897,
-0.0026377612,
0.016570803,
0.020930849,
-0.02291987,
-0.001320527,
0.004053788,
-0.009299672,
0.01379144,
0.031877063,
0.050002202,
0.0167157,
0.0032403956,
0.020522505,
0.0068166857,
0.024684966,
-0.0037113067,
-0.015214053,
0.026766194,
-0.03432712,
0.016215151,
0.006675083,
-0.009227224,
0.016860595,
0.0100570815,
0.017361144,
0.0013691001,
0.016965974,
0.0034709116,
0.009866083,
0.01683425,
-0.011473108,
0.015543361,
0.017848521,
-0.014068059,
-0.027214054,
-0.0019857301,
0.0036915482,
-0.012592757,
-0.0045148195,
0.0008644348,
-0.011163558,
0.026436886,
-0.0061383103,
0.026463231,
0.02639737,
-0.010524699,
0.003984633,
0.0062634475,
0.005110868,
-0.0090823285,
0.0042118556,
-0.02797805,
-0.032114163,
-0.015306259,
-0.0020285402,
0.004304062,
0.008871571,
-0.015266742,
-0.0017255765,
0.010103185,
-0.033958293,
0.0074687167,
-0.016623493,
0.023315042,
0.046234913,
-0.016649839,
-0.0086542275,
-0.0033951707,
0.00013244376,
-0.0034807909,
-0.009866083,
-0.013356753,
0.008812295,
0.011354557,
-0.01379144,
-0.012698135,
-0.02065423,
0.03754117,
-0.024500553,
-0.0018079036,
0.0015535129,
0.005874864,
0.013580683,
-0.01269155,
0.01852031,
0.007350166,
-0.008377608,
-0.015003295,
-0.03643469,
0.062173445,
-0.017295282,
-0.023117457,
0.021523604,
0.0014563669,
-0.02336773,
-0.14890014,
0.002461581,
0.0034379808,
0.015108674,
-0.0030131727,
0.002555434,
-0.0038232717,
0.017940726,
-0.008950605,
0.015978048,
-0.023459937,
-0.010149288,
-0.023262352,
-0.01384413,
0.0129879275,
0.0029901213,
0.0034281015,
-0.014739849,
-0.022840837,
0.011578487,
0.008693744,
-0.009036225,
0.010827663,
-0.0076992325,
-0.012862789,
-0.0030823275,
-0.017795831,
0.013804612,
0.0144105395,
0.018032933,
0.006204172,
0.011749728,
0.013607027,
-0.008930846,
0.0017799124,
0.007896818,
-0.0017963778,
-0.020733263,
0.025132824,
-0.009293086,
-0.014647642,
0.013778267,
0.01863886,
-0.0066948417,
-0.0055192104,
-0.011189903,
-0.018954998,
-0.018309552,
0.029427007,
-0.010412735,
-0.012994513,
-0.020048302,
-0.040728875,
-0.025554338,
0.024948413,
-0.013527993,
-0.00039270037,
0.01184852,
-0.00027353188,
0.017124042,
0.014621297,
0.004149287,
-0.014884744,
-0.0033951707,
0.033141606,
-0.006576291,
-0.020562023,
-0.034248084,
0.017650936,
-0.0062173447,
0.020008784,
-0.00835785,
-0.0015954997,
-0.002673985,
0.004613612,
0.009016466,
0.0055225035,
0.0020861693,
-0.022485184,
-0.012922065,
-0.0129879275,
-0.010425907,
0.007633371,
-0.004422613,
0.04718332,
-0.008193196,
0.019495063,
0.004531285,
0.009582877,
-0.00658617,
-0.017492868,
0.031165756,
0.022656424,
-0.028583977,
0.0016152582,
0.016425908,
-0.0012571352,
-0.009984634,
0.020759609,
0.029005492,
-0.004699232,
-0.0064182226,
-0.038305163,
0.004919869,
-0.029585075,
0.019863889,
0.001608672,
-0.0025323823,
0.0055653136,
-0.04396927,
0.0031053792,
0.037383102,
-0.006358947,
0.027003298,
-0.0041591665,
0.0072645457,
-0.037119653,
-0.02612075,
0.016518114,
-0.007488475,
0.0015098795,
0.033405054,
-0.0011616357,
-0.028979147,
0.009951703,
0.021049399,
0.01982437,
0.002346323,
-0.014463229,
0.0066915485,
0.0054500555,
-0.0010043909,
0.0064511537,
-0.037593856,
-0.006191,
0.012204173,
-0.018954998,
-0.0059868284,
-0.010860594,
0.0061416035,
0.016689355,
0.03005928,
-0.009470913,
-0.03401098,
0.022801321,
-0.035354562,
-0.00821954,
-0.009740945,
-0.03922723,
0.012777169,
0.017571902,
-0.019679476,
0.057273332,
0.020140508,
-0.0011558728,
-0.034695942,
-0.0125795845,
0.008766192,
0.016452253,
-0.016070254,
-0.012362241,
-0.042810105,
0.035723384,
0.013830957,
0.016452253,
0.012698135,
-0.0027991221,
-0.010116357,
-0.025462134,
-0.0071789254,
-0.0040603736,
-0.011980243,
-0.00073806266,
0.01475302,
0.0073369932,
0.0070735463,
0.020864986,
0.003372119,
-0.02758288,
0.014871572,
-0.0006602635,
0.008120747,
0.010564216,
0.01064325,
-0.026871573,
0.015938532,
0.05045006,
0.003958288,
-0.003177827,
0.030744242,
-0.0077321636,
-0.007863887,
-0.018954998,
0.027082331,
-0.0064873775,
0.0041657523,
0.0139231635,
0.017242594,
-0.00043715702,
0.023288697,
-0.0019412736,
0.019587269,
-0.019060375,
0.014028542,
-0.00007507205,
-0.036829863,
-0.009431396,
0.0068364446,
-0.037804615,
-0.016557632,
-0.019600442,
0.0086147105,
0.02584413,
0.013152582,
0.012856204,
0.007745336,
-0.015332604,
0.038542267,
-0.0073567517,
0.0041657523,
-0.014173438,
0.027609223,
0.024382,
0.0084105395,
-0.010201978,
-0.008792537,
0.0044028545,
0.010373218,
0.009424809,
-0.0076597156,
0.033246987,
-0.014792537,
0.021141605,
-0.031113068,
-0.057115264,
0.003839737,
-0.027319433,
-0.029980246,
0.02842591,
0.005160264,
-0.02211636,
0.054955002,
0.007165753,
-0.022142703,
0.00543359,
0.004567509,
0.025607029,
0.0038496163,
0.012223931,
0.00080104294,
-0.0038594955,
0.0107683875,
-0.0024023056,
0.017743142,
-0.03303623,
-0.004923162,
0.030217348,
-0.021352364,
-0.01717673,
0.016939629,
0.0053249183,
-0.0068496168,
-0.03733041,
-0.004607026,
0.009655325,
-0.026581781,
0.013001099,
0.027187709,
-0.014568608,
0.013949508,
-0.0107683875,
0.021997808,
-0.0027875965,
-0.056430303,
-0.012513723,
0.033115264,
-0.0014736556,
-0.013541166,
-0.0241449,
-0.009016466,
0.017769486,
-0.0021421518,
0.03237761,
-0.03090231,
-0.02319649,
-0.020746436,
-0.00035750555,
-0.008792537,
0.016360046,
0.00015271682
] |
BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by peripheral antigen which homed to the colonic mucosa. The clonal distribution of IgG secreting cells and isotype switched variants in UC is not known. AIMS To investigate the clonal distribution of mucosal IgG in UC and to search for related IgG and IgA secreting cells in normal and | [
-0.026141046,
0.0006882417,
0.017880527,
-0.015640605,
-0.0360459,
-0.009238057,
-0.035139572,
-0.00075985765,
0.0008699116,
0.003232025,
0.025661988,
0.0010422755,
-0.012520254,
0.0019825893,
-0.018683273,
0.0070305043,
0.02643884,
0.02590799,
-0.026348205,
0.0005818292,
-0.026697788,
0.021350462,
-0.00274973,
-0.027655905,
-0.013957428,
0.009632956,
0.014203431,
-0.04899342,
-0.009464638,
0.0090438435,
0.008564785,
-0.0029342321,
-0.011717507,
0.01571829,
-0.006655026,
-0.008079253,
0.035450313,
0.013918585,
0.0013837663,
0.018113583,
0.0061015193,
0.0054444326,
-0.007360666,
0.009082686,
0.008124569,
0.007820303,
0.0017349679,
-0.0013821479,
-0.0039846,
0.014850807,
0.04342599,
0.011885825,
-0.010960077,
0.0042370763,
-0.014643647,
-0.010701126,
0.013135261,
0.013776163,
-0.012371357,
-0.009380479,
0.012170671,
0.0002581412,
-0.0014582146,
-0.028510442,
0.0008820499,
0.0091603715,
-0.03897204,
-0.00022496318,
0.0055641974,
-0.0012931337,
0.01661167,
0.058004897,
-0.010642863,
-0.0142293265,
0.029002449,
0.0014404118,
-0.006489945,
-0.020340556,
-0.017181361,
0.014164588,
0.022761744,
-0.028924763,
-0.005049533,
0.018450217,
0.009393427,
0.021389306,
0.0015747423,
0.015873661,
-0.013983323,
-0.0036835698,
-0.0031721427,
0.024380183,
0.028432757,
0.002058656,
-0.012546148,
0.02654242,
-0.0021395779,
0.04446179,
0.024626186,
-0.039101515,
-0.0029827852,
0.008713682,
-0.0077490914,
-0.024613239,
-0.05526002,
0.0018239821,
-0.005010691,
-0.017984107,
0.0150838625,
-0.016029032,
0.002338646,
0.023007745,
-0.012261303,
-0.017880527,
0.037107598,
-0.019343598,
0.026335258,
0.0016669934,
0.007192348,
-0.014643647,
-0.005764884,
-0.0016831778,
0.0040881797,
-0.010824128,
0.013646687,
0.007082294,
-0.030685626,
-0.0024147127,
0.011581558,
-0.0022965667,
0.01211888,
0.03620127,
0.008940264,
0.017751051,
-0.0033501713,
-0.004868268,
-0.0145141715,
0.0015779792,
-0.008370573,
-0.017660419,
-0.004871505,
0.025558406,
0.0017802842,
-0.013251788,
-0.0017527707,
0.007444825,
0.018113583,
0.016637566,
0.014099851,
0.018722117,
0.0016184401,
-0.025260614,
-0.014540067,
-0.025571356,
0.015679449,
0.025053455,
0.005816674,
0.028562233,
-0.007548405,
-0.029416768,
-0.009225109,
-0.019408334,
0.014553014,
0.010739969,
0.015019125,
0.021466991,
-0.0043536043,
0.01010554,
-0.0069204504,
0.00034472777,
0.00031256126,
0.031980377,
-0.0052113775,
0.015381656,
-0.0024406079,
0.0011952181,
-0.027189795,
0.009827169,
-0.03332692,
-0.025985675,
-0.033793032,
0.021803627,
0.00029233075,
-0.021648256,
-0.0033501713,
-0.013387737,
0.028639918,
-0.013983323,
-0.008461205,
-0.009522902,
0.01869622,
0.028199703,
0.012500832,
-0.042726822,
-0.6247956,
-0.010616967,
0.024936926,
-0.0051563503,
0.0039328095,
0.0350101,
0.017828736,
-0.015783029,
-0.021661203,
-0.014980283,
-0.0063669435,
0.019861499,
0.0010616968,
0.0100472765,
0.009503481,
-0.01630093,
-0.013944481,
-0.0036188322,
0.012610886,
-0.008305835,
-0.010390386,
-0.005379695,
0.019291807,
0.015420498,
-0.0024503185,
0.011290239,
-0.006541735,
-0.020081606,
-0.00023163925,
0.01943423,
-0.031022262,
0.009464638,
-0.0023176062,
-0.023525646,
0.047154874,
0.00053732214,
-0.014125746,
0.0026121624,
0.014125746,
0.021868363,
0.0045057377,
-0.013763215,
0.021479938,
-0.031229421,
-0.024626186,
0.025584303,
0.010124962,
0.01786758,
0.02251574,
-0.00958764,
-0.0024147127,
0.012792151,
-0.009374006,
0.010701126,
0.04319293,
0.015524078,
0.0016281508,
-0.0035314364,
0.007762039,
-0.0049686115,
0.0021460517,
0.023370277,
-0.037651394,
-0.025480723,
-0.006952819,
-0.004165865,
-0.022425108,
-0.010662284,
0.013750268,
0.01120608,
0.016974201,
0.008875526,
0.0025312405,
-0.006276311,
0.020068659,
0.031850904,
-0.012818046,
0.005039823,
0.0013166011,
0.016184403,
-0.0069916616,
-0.0023515937,
-0.00464816,
0.019045804,
0.02580441,
-0.0042564976,
-0.01327121,
0.014281116,
-0.01373732,
-0.0066129467,
0.0028516916,
0.019874446,
-0.012461989,
-0.038842563,
-0.018553799,
0.04174281,
-0.029339084,
0.0024422263,
-0.00086020096,
-0.013659636,
0.0020829325,
-0.01089534,
-0.0066679735,
0.026231678,
0.024703871,
0.012151249,
-0.033715345,
0.020198133,
0.03311976,
-0.021661203,
-0.0062374687,
0.01802295,
0.01107013,
-0.014281116,
0.01494144,
-0.012830994,
0.006302206,
0.013335947,
-0.0055285916,
-0.0028516916,
0.048604995,
-0.012869837,
0.019408334,
-0.0097948,
-0.013148208,
0.0054314854,
0.022204999,
-0.038117502,
0.018152425,
-0.018152425,
-0.0073800874,
-0.020016868,
0.036900435,
-0.0052987733,
0.031358898,
-0.006745659,
0.034802936,
0.0054670908,
-0.010118488,
-0.03897204,
-0.028070226,
-0.010610494,
0.014177536,
0.006784501,
0.0037968606,
0.013672583,
-0.0057486994,
0.00029860222,
-0.007166453,
0.009005001,
0.013750268,
-0.007839724,
-0.01172398,
0.023370277,
0.0037515443,
0.0031397738,
-0.019123489,
-0.028432757,
-0.009613534,
-0.020664245,
-0.00057050015,
0.019330649,
0.019330649,
0.014488276,
-0.001102967,
0.010539282,
0.001772192,
0.030763311,
-0.0072700335,
-0.0027756249,
-0.00002756406,
-0.009322216,
-0.021557624,
0.022476897,
0.025403038,
-0.012190091,
-0.031773217,
0.0036058847,
-0.021803627,
0.008325256,
-0.008888474,
-0.014824912,
0.016287982,
-0.012649729,
0.01630093,
-0.0127403615,
0.035709266,
0.017932318,
-0.011594505,
0.017259046,
0.009082686,
-0.0016637566,
-0.04000784,
0.0016451444,
-0.0077685127,
-0.016805883,
-0.0026866107,
0.009827169,
0.045109164,
0.013776163,
-0.005496223,
-0.017686315,
0.008998527,
-0.0059914654,
0.027034424,
-0.02700853,
0.01125787,
-0.011866404,
0.05458675,
-0.02287827,
0.001143428,
-0.0009014712,
0.007943304,
0.0019065225,
0.013983323,
0.021169197,
-0.017932318,
-0.0012842322,
0.017051885,
-0.022023734,
-0.016210297,
0.025778515,
0.01964139,
0.011808139,
-0.013128786,
0.016546933,
0.01060402,
0.019667285,
-0.004916821,
-0.012746835,
-0.003761255,
0.014540067,
-0.00864247,
-0.01582187,
-0.00802099,
0.002246395,
0.0064252075,
-0.001257528,
0.011225501,
0.008079253,
0.006441392,
0.011348503,
0.0031948008,
0.01358195,
0.018877486,
-0.006353996,
0.017155467,
0.010992446,
-0.014760175,
0.015537025,
-0.023978809,
-0.000981584,
-0.012792151,
-0.019654337,
-0.019084647,
-0.014022166,
0.0065838145,
-0.007302402,
0.038454138,
0.012177144,
0.011607453,
-0.005169298,
-0.009930749,
0.0036997544,
0.0011272436,
0.029054238,
-0.0046675815,
-0.020262871,
-0.01509681,
0.020677192,
-0.020236976,
-0.008008042,
0.014837859,
-0.019783814,
0.0010560323,
0.03265365,
0.03630485,
0.012636781,
0.012196565,
0.008823736,
-0.013070523,
-0.0360459,
0.009425796,
0.026464734,
0.001360299,
0.0008258091,
-0.024341341,
-0.026348205,
-0.021246882,
0.0040363898,
-0.0032999995,
0.022917112,
0.018100634,
0.0014217997,
-0.0071146633,
-0.005787542,
0.022308579,
-0.024419025,
-0.010739969,
0.015381656,
-0.008377046,
-0.018294849,
-0.007606669,
0.02000392,
0.002460029,
0.03948994,
0.0054217745,
0.002338646,
-0.013012259,
-0.0009921038,
-0.009128002,
-0.0077685127,
-0.00038357032,
0.01353016,
-0.015381656,
0.015614711,
0.022425108,
-0.007794408,
0.045316324,
-0.004104364,
-0.015329866,
-0.019952131,
-0.015562921,
-0.012837468,
0.015329866,
0.0062439423,
-0.017038938,
0.030271305,
0.024224812,
-0.009730062,
-0.011283765,
-0.033352815,
0.01812653,
-0.012397252,
-0.036641486,
0.022839427,
0.005544776,
-0.017686315,
0.012228934,
0.012533201,
-0.0010277096,
-0.023033641,
-0.004275919,
0.011749876,
0.01457891,
0.007988621,
0.020301715,
0.018217163,
0.0023920545,
-0.03164374,
0.008402942,
0.0031737613,
0.01938244,
-0.013491318,
-0.022697005,
0.032834914,
-0.005292299,
-0.0063669435,
-0.018786853,
-0.013789111,
0.010176752,
-0.0050560073,
-0.0047808723,
-0.017789895,
0.009930749,
0.01891633,
0.0045316326,
-0.008687787,
-0.0055318284,
-0.020936143,
0.0013570621,
0.024367236,
-0.0028047569,
-0.019939182,
0.020405294,
-0.03687454,
0.0020570375,
-0.043089353,
0.016313877,
0.0027189795,
-0.002665571,
0.0042953403,
0.004321235,
-0.021337515,
-0.012727413,
-0.010429229,
0.004084943,
0.0058522797,
-0.01681883,
-0.032058064,
-0.007438351,
-0.02539009,
-0.00838352,
0.02236037,
-0.0074189296,
-0.032886706,
0.007826777,
0.017453259,
-0.005030112,
0.015899556,
0.0073412447,
-0.0028953895,
-0.0005077856,
0.018398428,
0.011769297,
-0.02131162,
0.00074691017,
-0.014281116,
-0.0008747669,
0.021013828,
0.04057753,
-0.009108582,
-0.021712994,
0.018553799,
-0.012280724,
-0.01494144,
-0.018903382,
0.018903382,
-0.009199214,
-0.0051757717,
0.01353016,
-0.004518685,
-0.010642863,
-0.027863067,
0.0033339867,
-0.009225109,
-0.01604198,
-0.006648552,
0.012960469,
-0.017841684,
-0.015032073,
0.0055253548,
-0.014721332,
-0.0075419312,
0.007548405,
-0.003492594,
-0.004373025,
-0.01927886,
0.0043438934,
0.018268952,
-0.012869837,
0.013789111,
0.020353504,
-0.025920939,
0.0054670908,
-0.0125396745,
0.024807451,
-0.0015577486,
-0.0156017635,
0.021557624,
0.00006337205,
-0.019097595,
-0.003997547,
-0.02726748,
-0.0051045604,
0.023693964,
-0.010493966,
-0.02225679,
-0.028950658,
0.010280332,
0.0024584106,
0.033974297,
-0.010513388,
-0.033870716,
-0.017673368,
-0.002639676,
-0.0070434515,
-0.004301814,
0.024742713,
-0.026594209,
0.0071858745,
0.0381434,
0.009341637,
-0.01953781,
0.018359585,
-0.0042370763,
0.0030944576,
0.010882392,
-0.011380872,
-0.020599507,
-0.0137114255,
-0.01358195,
0.028484548,
0.0428304,
0.038272873,
0.0031462477,
0.022645215,
0.007710249,
-0.00088852365,
0.013594897,
-0.014540067,
0.014099851,
-0.032938495,
0.0027270718,
-0.010416281,
0.0008893329,
0.015549974,
-0.025920939,
0.0093610585,
0.031462476,
-0.02711211,
-0.008351151,
-0.018165372,
-0.024988716,
-0.022192052,
0.015433446,
0.006260127,
0.01583482,
-0.025946833,
-0.022800585,
0.014799017,
0.019136436,
0.0145141715,
-0.002809612,
0.022658162,
-0.0107076,
0.02241216,
-0.015278075,
-0.0041108383,
0.019240016,
0.008305835,
0.0036576749,
0.0020198133,
0.0019534572,
0.030064145,
0.012869837,
0.0028921526,
-0.006056203,
-0.000097308715,
-0.005823148,
-0.025765568,
-0.008519469,
0.0050204014,
-0.019473072,
-0.024224812,
0.026348205,
-0.0063248645,
-0.044021573,
0.000024377756,
-0.008700734,
-0.011225501,
0.02251574,
-0.017543891,
-0.019084647,
0.017271994,
0.009425796,
0.024483763,
-0.051168606,
0.009730062,
0.02690495,
-0.0010908287,
-0.033301026,
0.017155467,
-0.028847078,
0.0125073055,
0.028199703,
0.025869148,
0.010908287,
-0.017233152,
0.0030653258,
0.0071276105,
0.010364491,
-0.03933457,
0.012261303,
0.03948994,
0.00995017,
-0.02356449,
-0.017479153,
-0.0024211865,
0.00052397,
-0.0143976435,
0.004466895,
-0.0129281,
0.010662284,
-0.026361154,
0.02100088,
-0.01650809,
0.02215321,
-0.019032856,
0.00045397246,
-0.031151736,
-0.023499751,
-0.0127403615,
0.005764884,
0.016546933,
0.0053473264,
-0.012953995,
0.0043536043,
0.0010463216,
0.0048585576,
0.009115055,
0.0052631674,
-0.015006177,
0.04226071,
-0.011827561,
0.0001565841,
0.015187442,
0.010040803,
0.021441096,
-0.0052049034,
0.0069075027,
-0.019615496,
-0.005593329,
-0.009995487,
0.034906518,
0.013866795,
-0.034543987,
0.0066129467,
-0.013931533,
0.013569002,
-0.034362722,
-0.007192348,
-0.004712898,
-0.022955956,
-0.008202255,
-0.007820303,
0.017077781,
0.012675623,
0.002651005,
0.012474937,
-0.0040266793,
0.005836095,
-0.022852376,
-0.00514664,
-0.0057713576,
-0.009251004,
0.0005919445,
0.010034329,
-0.013957428,
-0.0097624315,
0.01404806,
-0.0032287883,
-0.021078564,
-0.019123489,
-0.02711211,
0.00302972,
-0.0052243248,
-0.02554546,
-0.0042435504,
0.02544188,
0.01714252,
-0.00660971,
-0.0040493375,
0.01938244,
-0.013491318,
-0.00017732035,
0.0022593425,
0.000619458,
0.009872485,
0.004198234,
0.01141324,
-0.00066396507,
-0.0007792789,
-0.02110446,
-0.014423539,
-0.004104364,
-0.017233152,
-0.014643647,
-0.016482195,
0.010901813,
-0.018191267,
-0.00428563,
0.0039619417,
-0.01075939,
-0.020172238,
0.010073172,
-0.00068136334,
0.030115934,
0.0059752814,
-0.018942224,
-0.025247667,
-0.006528788,
-0.012953995,
-0.00530201,
-0.021285726,
0.033404604,
0.000893379,
-0.0030394306,
-0.03840235,
-0.0023693964,
-0.029028343,
-0.0008480626,
0.008292887,
-0.0049459534,
0.017958213,
0.032524172,
-0.00903737,
0.023409119,
-0.026011571,
0.0070046093,
-0.02157057,
0.01953781,
0.02570083,
-0.012261303,
0.022334475,
0.0032951443,
-0.013659636,
-0.025830306,
0.012002353,
0.007885041,
-0.014553014,
0.040836483,
-0.021712994,
0.02084551,
-0.0010819272,
0.00011501041,
-0.020923195,
0.014086903,
0.018851591,
-0.011549189,
-0.005690436,
-0.0018029424,
-0.011523294,
0.00015021148,
0.010034329,
0.023875229,
-0.00469995,
0.009412848,
0.0017543891,
-0.035657473,
0.00041836678,
-0.00802099,
0.0240306,
0.011102499,
-0.023836387,
0.019576652,
0.0018838644,
-0.004194997,
-0.03892025,
0.0042435504,
-0.0025037269,
0.0013335947,
-0.00035201074,
-0.02423776,
-0.012060616,
-0.010778812,
-0.0051757717,
-0.012041195,
-0.016275035,
-0.019097595,
0.008907895,
-0.040499847,
0.014721332,
0.0017382047,
0.0029876407,
-0.0038098083,
-0.0028775868,
-0.018579694,
-0.007710249,
-0.00505277,
-0.0000036857446,
-0.007982147,
-0.000547842,
-0.005408827,
-0.00015648293,
-0.010170278,
0.0004031939,
-0.025778515,
-0.025247667,
0.000059325946,
0.1833369,
-0.02110446,
0.015614711,
-0.00021687099,
-0.019123489,
-0.022386264,
0.00018035492,
-0.009665324,
-0.018618535,
0.027966646,
0.03374124,
-0.022010786,
-0.0059752814,
0.0057454626,
0.007820303,
-0.026490629,
-0.03311976,
-0.035113677,
-0.0011515202,
-0.01530397,
0.00063928385,
-0.0145141715,
0.019719075,
0.0006186488,
0.017181361,
-0.020146344,
-0.014721332,
0.040655218,
0.03311976,
0.036848646,
-0.0214152,
0.031954482,
0.021855416,
0.002566846,
-0.009289847,
0.013491318,
-0.02685316,
-0.018346637,
-0.014436486,
0.025636092,
-0.00031964193,
0.005683962,
-0.0137114255,
0.0079562515,
-0.022554582,
-0.007354192,
-0.0017301126,
-0.0070175566,
-0.008046885,
0.009710641,
-0.018618535,
-0.009833642,
0.0036641485,
0.02523472,
0.012384304,
-0.015381656,
0.014203431,
0.0042564976,
-0.0009071357,
0.013452475,
0.009432269,
0.0044733686,
-0.030737417,
0.041069537,
-0.0057810685,
0.037262965,
-0.0066938684,
-0.024004705,
-0.015057967,
0.000094982206,
0.013310052,
-0.012811572,
-0.020444136,
-0.0027189795,
-0.011872877,
0.018346637,
0.016741145,
0.0480612,
0.0068557127,
0.008713682,
0.017854633,
0.016417457,
-0.03796213,
-0.003301618,
-0.015342813,
-0.034077875,
0.009827169,
0.022593426,
-0.041768704,
-0.013853848,
-0.015757134,
0.0040881797,
-0.010901813,
-0.0036123586,
-0.017725157,
-0.009581166,
0.0070563992,
0.020858457,
0.019460125,
-0.013569002,
-0.0129086785,
0.09301499,
0.021402253,
0.02179068,
-0.04042216,
0.011918194,
0.006227758,
-0.007386561,
-0.0014849189,
0.0049362425,
0.019149384,
-0.025998624,
-0.0030539967,
-0.01681883,
-0.005386169,
0.032575965,
0.00333075,
-0.0042662085,
0.035398524,
0.012235408,
0.0014315103,
-0.008241097,
0.01494144,
0.0050689545,
-0.013232367,
-0.015498183,
-0.010040803,
0.029054238,
0.0028775868,
-0.03071152,
-0.0028435993,
-0.027811276,
0.014384696,
-0.0038615982,
-0.006538498,
0.03405198,
-0.0058069634,
-0.017414417,
-0.019227069,
0.016546933,
-0.032109853,
0.0100472765,
0.008629523,
-0.002570083,
0.019369492,
0.000036136735,
0.0020214317,
0.0093999,
-0.012811572,
-0.01125787,
0.010280332,
-0.01869622,
-0.03275723,
-0.0046675815,
0.025182929,
-0.024561448,
-0.022852376,
-0.022943009,
-0.010092593,
0.015537025,
-0.014669542,
0.016378615,
0.029339084,
-0.0075872475,
0.00024134989,
-0.011400293,
-0.1598242,
0.025299458,
0.013569002,
0.0079562515,
0.0117369285,
-0.0075613526,
-0.025299458,
0.012248355,
-0.022748794,
0.015498183,
0.036900435,
-0.006137125,
-0.0334305,
-0.008849631,
0.004842373,
0.0030459045,
-0.03783266,
0.026646,
0.017984107,
0.0029585087,
0.031566057,
-0.025895042,
-0.000101759426,
-0.020236976,
-0.0078008818,
-0.010409807,
0.0143976435,
0.02157057,
-0.010338596,
-0.0046967133,
-0.006875134,
-0.022943009,
0.03871309,
-0.009328689,
-0.0015763608,
-0.01368553,
-0.026244625,
-0.017686315,
0.009121529,
0.019719075,
0.025221772,
0.007995094,
0.01676704,
0.021376358,
-0.028355071,
0.044125155,
0.012203039,
0.019913288,
0.041820493,
0.008532417,
0.010850023,
-0.0014088522,
0.013620793,
0.035450313,
-0.0047193714,
0.026296416,
0.023875229,
0.024626186,
-0.008357625,
-0.005473565,
0.000886096,
-0.023163116,
0.018631482,
0.012785678,
-0.006771554,
-0.02125983,
0.020625401,
0.016029032,
0.012474937,
0.009658851,
-0.004942716,
-0.006687395,
0.010688179,
-0.012429621,
0.033715345,
0.00023912454,
-0.01881275,
0.021751836,
-0.013879743,
0.004602844,
-0.027034424,
-0.008707209,
-0.023732807,
-0.01060402,
-0.020327609,
0.009963118,
-0.0028889158,
0.02157057,
-0.002930995,
-0.018476114,
0.021609413,
-0.038272873,
-0.012092985,
-0.0038324664,
0.009341637,
0.03798803,
-0.020897299,
0.00040804924,
-0.026076308,
-0.015109758,
0.037444234,
-0.032938495,
-0.034673464,
0.014190484,
0.024613239,
0.001540755,
-0.005013928,
-0.03542442,
0.033301026,
-0.0028970079,
-0.015653554,
0.014073956,
0.026879055,
0.028329177,
-0.018424323,
-0.0028953895,
0.009840116,
0.0019162332,
0.027578222,
-0.05997292,
0.07903167,
0.014501224,
0.014786069,
-0.0039101513,
-0.00671329,
-0.030892786,
-0.119013615,
-0.024626186,
0.017297888,
0.010118488,
-0.013840901,
-0.016313877,
-0.0059429123,
0.015990188,
-0.015705343,
0.0042079445,
-0.004418342,
-0.0075160363,
0.0172461,
-0.015161548,
0.01948602,
0.01781579,
0.008888474,
-0.0031591952,
-0.023836387,
0.012934574,
-0.02706032,
-0.004217655,
-0.009730062,
-0.007865619,
-0.018553799,
-0.007897988,
-0.0145141715,
0.025403038,
0.011497399,
0.013815005,
0.001786758,
0.008907895,
0.0055285916,
-0.0081569385,
0.010681706,
-0.0058069634,
-0.009263951,
-0.015808923,
0.031333003,
-0.025985675,
-0.008597154,
0.0141127985,
0.002720598,
-0.012241881,
0.008260518,
-0.0057325154,
-0.012494358,
-0.0023467382,
0.032498278,
-0.034440406,
-0.034129668,
-0.033818927,
-0.051867772,
-0.008733103,
0.015653554,
0.021609413,
-0.007548405,
0.02267111,
-0.027500536,
0.012837468,
0.0037224125,
-0.013335947,
-0.046455707,
0.012449042,
0.03400019,
0.0037709656,
-0.005059244,
-0.0043050507,
0.0063410485,
-0.035450313,
-0.01583482,
-0.028225597,
-0.02465208,
0.009956644,
0.0077296705,
-0.0012445805,
0.008810788,
-0.0005069764,
-0.009956644,
-0.014138693,
-0.0053214314,
-0.014928493,
0.006286022,
-0.002735164,
0.023214906,
0.011588031,
-0.0015237614,
0.0036447274,
-0.0015998281,
0.002786954,
-0.0025021085,
0.03311976,
0.016650513,
-0.033249237,
-0.014462382,
0.0001265418,
-0.0075743003,
-0.028355071,
0.0067974487,
0.012151249,
0.0021233936,
-0.02058656,
-0.049640797,
0.022204999,
0.0047193714,
0.0066615,
0.010377439,
-0.01337479,
0.01342658,
-0.009930749,
0.017077781,
0.044125155,
-0.009516428,
0.031747323,
0.009710641,
0.0027011766,
-0.016495142,
-0.0056936727,
0.020379398,
0.007787934,
-0.011594505,
0.028484548,
0.0064834715,
-0.003312947,
-0.0034828833,
0.01781579,
-0.016443353,
0.015899556,
-0.01494144,
0.030737417,
-0.015019125,
-0.01807474,
0.00052154233,
-0.033663556,
-0.026231678,
0.034388617,
-0.0033890137,
-0.001007479,
-0.00843531,
0.056865513,
-0.0013279301,
0.0318768,
-0.004771162,
-0.037936237,
0.0068621864,
0.016598722,
-0.017064834,
-0.0047549773,
-0.041069537,
0.032135747,
-0.0063766544,
-0.009225109,
0.049226478,
0.0253383,
0.017621577,
-0.049071107,
-0.021220988,
0.0067262375,
0.000115516166,
0.020547716,
-0.027992541,
-0.009937223,
0.009509955,
0.0020602744,
0.0040946538,
0.019939182,
-0.006140362,
-0.016287982,
-0.036071796,
-0.015912503,
0.016689355,
-0.015562921,
0.0017252573,
-0.0164563,
-0.012526727,
-0.0017527707,
0.030297201,
0.01812653,
-0.009581166,
0.007930357,
0.0057843053,
0.028872972,
0.019097595,
0.0016637566,
-0.018566746,
0.012856889,
0.040681113,
-0.0069398717,
0.002882442,
-0.0004948381,
0.003971652,
-0.0069075027,
0.0051628244,
0.013323,
0.0005053579,
0.003544384,
-0.022748794,
0.011024814,
0.0063766544,
-0.0038357032,
0.00995017,
0.036745068,
-0.0032724862,
0.016676407,
0.010888865,
-0.02413418,
-0.0026461496,
0.0071017155,
-0.035113677,
-0.062251683,
-0.028199703,
0.027785381,
-0.0015059586,
-0.00021808481,
-0.00020796957,
0.008092201,
-0.013672583,
0.0126238335,
-0.016249139,
0.009548797,
-0.011212554,
0.018735064,
-0.015459341,
0.003958705,
-0.027681801,
-0.011840508,
-0.0012203039,
-0.0045348695,
0.0139962705,
-0.00843531,
0.018709168,
0.01404806,
0.00026704263,
-0.021868363,
-0.041224908,
-0.016598722,
0.00011652769,
-0.006276311,
0.028847078,
0.020288765,
-0.015666502,
0.074215196,
-0.0034278564,
-0.008195781,
0.0013230748,
-0.016779987,
0.0036285429,
0.0036317797,
0.0064543393,
0.022593426,
0.0024114759,
-0.0034310932,
0.010804706,
0.027422851,
-0.045057375,
-0.029183714,
0.01342658,
0.010610494,
-0.009458165,
0.016676407,
-0.011400293,
0.029364979,
-0.01404806,
-0.0042338395,
-0.00560304,
-0.0127403615,
-0.002312751,
0.019304754,
-0.0122548295,
-0.01984855,
-0.042493764,
0.01353016,
0.0074771936,
-0.029442664,
-0.02189426,
-0.0017964686,
-0.02167415,
0.0031413925,
-0.0020003922,
0.016495142,
0.017919369,
-0.02747464,
0.054845702,
-0.01823011,
-0.0039943103,
-0.017841684,
-0.045264535,
-0.033456396,
-0.0068945554,
-0.004683766
] |
BACKGROUND Kulldorff's spatial scan statistic and its software implementation - SaTScan - are widely used for detecting and evaluating geographic clusters. However, two issues make using the method and interpreting its results non-trivial: (1) the method lacks cartographic support for understanding the clusters in geographic context and (2) results from the method are sensitive to parameter choices related to cluster scaling (abbreviated as scaling parameters), but the system provides no direct support for making these choices. We employ both established and novel geovisual analytics methods to address these issues and to enhance the interpretation of SaTScan results. We demonstrate our geov | [
-0.010804363,
0.016076123,
0.032728843,
-0.020386886,
-0.014991568,
0.027910126,
-0.024258334,
-0.013474564,
-0.020345699,
-0.030751934,
0.0047638044,
0.0039263633,
-0.008951009,
0.004176909,
-0.0035213712,
0.0028452403,
0.023420893,
-0.019274874,
0.003414975,
0.0029945383,
-0.019892657,
0.0029070189,
-0.0038096705,
-0.00030996476,
-0.012424331,
0.027772842,
0.020510443,
-0.028692653,
-0.018149134,
-0.009376595,
-0.0053472673,
-0.015897652,
-0.018437432,
-0.012012474,
-0.04115817,
-0.010763177,
0.0012553036,
-0.01129859,
-0.013673628,
-0.018506074,
-0.0066240216,
0.00197691,
0.007564427,
-0.049367838,
0.037039608,
0.014250227,
0.0041116984,
-0.014744454,
-0.0156230815,
-0.001317082,
0.012314502,
0.04390388,
-0.02807487,
0.004808422,
-0.0061194976,
-0.005144771,
0.0059170015,
0.0013462552,
-0.0027800298,
-0.049560037,
-0.009404051,
0.0072898557,
-0.025919488,
0.023915121,
-0.0033360359,
-0.035145067,
-0.01799812,
0.006198437,
-0.019096402,
0.018107947,
0.029269252,
0.04692416,
-0.015568167,
0.011614347,
0.0138315065,
-0.012685173,
0.014009978,
-0.016941022,
0.002402495,
0.0028452403,
-0.0004077806,
-0.02052417,
-0.0128979655,
0.033497643,
-0.0003093212,
0.019673001,
-0.0200574,
0.015760366,
-0.022432439,
0.016089851,
-0.009815908,
0.024807476,
0.019755373,
0.0051550674,
-0.024505448,
0.0032090468,
0.009630572,
0.028994681,
-0.00069929764,
0.0014123238,
-0.030751934,
0.0021656775,
-0.0070976564,
-0.01875319,
-0.025438989,
0.0015324486,
0.00936973,
-0.0017280802,
0.017476434,
-0.013845235,
-0.0117035825,
0.045880787,
-0.016282052,
0.015774095,
0.003111231,
-0.015677996,
0.028472997,
-0.020098586,
-0.021059584,
-0.017394064,
0.0052786246,
-0.011504519,
0.029214337,
-0.008772539,
0.024340706,
0.0074545983,
-0.011957561,
-0.011271133,
-0.045908246,
-0.033936955,
-0.010790634,
0.030147878,
0.00785959,
0.0007417703,
-0.026976585,
0.011353505,
-0.0024248038,
0.0062053013,
-0.016446793,
-0.021512626,
0.003922931,
0.027937584,
0.0053850207,
-0.03042245,
-0.006531354,
0.014209041,
0.015801553,
0.047500756,
-0.0024162235,
-0.022679552,
0.0058929767,
-0.030175336,
0.0007799528,
0.00021815512,
-0.008882367,
-0.015609353,
-0.009527609,
0.0038268312,
-0.004962868,
-0.034129158,
-0.019576902,
0.027951311,
-0.010893598,
-0.0013136499,
0.009280494,
0.033415273,
0.0043244907,
-0.004424023,
-0.015581896,
0.00044660663,
-0.008957874,
0.045166906,
-0.011511383,
0.023695463,
-0.008388139,
0.011662397,
-0.0049285465,
0.025658645,
-0.013392193,
-0.030971592,
-0.0032588127,
0.028225884,
-0.00079882954,
0.011017155,
0.0035282355,
-0.013048979,
0.025219332,
0.0043141944,
0.013639307,
-0.0124106025,
0.01102402,
0.002047269,
-0.0026118553,
0.0034492963,
-0.62514293,
-0.02542526,
0.024423078,
-0.031603105,
-0.0052820565,
0.011044612,
0.026839301,
0.016968478,
-0.0132343145,
0.044013705,
-0.01276068,
0.0055703563,
-0.0021313562,
-0.009376595,
-0.042613395,
-0.025809659,
-0.014648355,
-0.012630259,
0.030394992,
0.022446167,
-0.03887923,
0.028610282,
0.006582836,
0.015005297,
0.0068196533,
0.027086414,
0.011319183,
-0.0053850207,
0.023009038,
0.0028726975,
-0.014524798,
0.017037122,
0.009898279,
0.009658029,
0.037890777,
-0.017833376,
-0.025850846,
0.010214035,
0.022363795,
0.034925412,
-0.01153884,
-0.052882344,
0.020963484,
0.009925736,
-0.01488174,
0.015760366,
-0.009946329,
-0.008141026,
-0.03327799,
-0.011422147,
-0.013742271,
0.002153665,
-0.012417466,
0.020565357,
0.019329788,
-0.0044926656,
0.011429012,
-0.019837745,
0.004454912,
0.0049971896,
-0.0026187194,
0.008923553,
0.0037375956,
-0.0013822926,
-0.011682989,
0.027278613,
-0.009191259,
0.008546018,
0.0070255813,
-0.012705766,
0.010570978,
0.016062394,
-0.004200934,
-0.019425888,
0.01875319,
0.027937584,
0.027745385,
-0.016117308,
0.0067407144,
-0.003593446,
0.00758502,
-0.009012788,
-0.039400917,
-0.004664272,
0.017215593,
-0.022061767,
-0.019151317,
0.026880486,
0.017764734,
0.015801553,
-0.0035625568,
0.018409975,
-0.012369417,
-0.05744022,
0.009534473,
0.021704825,
-0.009555065,
0.019384703,
-0.0050212145,
-0.04189951,
-0.05123492,
-0.0024917305,
0.0038028061,
0.016282052,
0.023475807,
0.013220586,
-0.013817778,
-0.009953193,
0.029488908,
-0.0081204325,
0.01591138,
0.0023287039,
-0.012705766,
0.0037581886,
-0.00015873626,
-0.022652095,
0.028418083,
-0.004424023,
-0.014195313,
-0.008333225,
0.008683303,
0.014071756,
0.023036495,
-0.01835506,
-0.0021982829,
0.020167228,
0.0029722294,
-0.010852412,
-0.015787823,
-0.021704825,
-0.031053962,
-0.008889231,
0.022528538,
-0.0064386865,
0.03476067,
0.0046780007,
0.01525241,
-0.0030494526,
0.007990012,
-0.03336036,
-0.018972846,
-0.019961301,
0.0019889225,
-0.016487978,
-0.013172536,
-0.015403424,
-0.010804363,
-0.005790013,
0.004530419,
-0.007777219,
-0.0009241025,
-0.021828383,
-0.0055085775,
0.0064695757,
0.008429325,
0.009822772,
0.014209041,
-0.03767112,
-0.022212781,
-0.0339095,
0.017435249,
0.021732282,
-0.03023025,
-0.0061950046,
-0.020071128,
-0.042805593,
-0.010152257,
0.009726672,
-0.015334782,
-0.029461453,
0.0016843205,
-0.021526353,
0.014263956,
0.014634626,
-0.020510443,
0.0021999988,
0.0016070975,
-0.01676255,
-0.018025575,
-0.0072280774,
0.022281425,
0.0085666105,
-0.010838684,
-0.008834317,
0.029269252,
0.024134777,
0.006507329,
-0.006853975,
-0.032344446,
0.010982834,
0.0012656,
0.021251783,
-0.043546937,
0.013199993,
0.006936346,
0.008930417,
-0.010529792,
0.012390009,
0.005927298,
0.022679552,
0.011799682,
0.0151013965,
0.01210171,
0.0052168462,
0.04876378,
-0.033415273,
-0.0024179395,
-0.014497341,
0.009294223,
0.0050486713,
0.009362866,
-0.007749762,
-0.024519177,
-0.016364422,
0.010516063,
0.017037122,
-0.003394382,
-0.0004019889,
0.0021639615,
0.008415597,
0.004458344,
-0.0046196543,
0.04118563,
0.0017426668,
0.0057556913,
0.007070199,
-0.007990012,
0.015019026,
0.009891415,
-0.031493276,
-0.019206231,
0.00809984,
-0.0026942263,
0.026290158,
0.023160052,
0.0070221494,
0.02439562,
-0.003974413,
0.013797185,
-0.004859904,
0.007921369,
0.034815583,
0.007694848,
-0.020331971,
0.01902776,
-0.0012261304,
0.034293897,
0.0040464876,
-0.0047226185,
0.0040155984,
-0.018382518,
-0.0027491406,
-0.022748195,
-0.0018121676,
0.0038680169,
-0.011813411,
0.009259902,
0.004176909,
0.008861774,
0.041762225,
0.020043671,
0.0205379,
0.006610293,
-0.013996249,
-0.010413099,
0.0068230857,
0.02666083,
-0.0051310426,
0.022020582,
0.014250227,
0.023709193,
-0.009232445,
-0.017902019,
-0.007365363,
0.0132343145,
0.006802493,
0.01808049,
0.026853029,
0.012643987,
0.008381275,
-0.026166601,
-0.032838672,
0.039950058,
0.030010594,
-0.015224953,
0.00090779987,
-0.014291412,
-0.019041488,
-0.024354434,
0.0007314739,
-0.0034716052,
0.012479245,
0.0019614655,
-0.012595938,
-0.012190945,
0.01205366,
0.013920742,
0.009863958,
-0.000054967797,
0.03909889,
-0.010921055,
0.00038032353,
-0.003929795,
-0.019370973,
0.06375535,
0.00066197314,
-0.0013333847,
-0.007262399,
-0.0055051455,
-0.006157251,
0.0016113877,
-0.00642839,
-0.0050521037,
0.021251783,
0.0020558492,
0.012472381,
-0.009603116,
-0.008779403,
0.03344273,
0.031246163,
-0.0035831495,
-0.02042807,
-0.011971289,
0.006304833,
0.03802806,
-0.007207485,
0.005264896,
0.014730726,
0.0047432114,
0.0045956294,
-0.01271263,
-0.01658408,
0.0197691,
-0.0012003895,
-0.02100467,
-0.017915748,
0.021787196,
-0.006980964,
0.029159423,
0.03503524,
0.0057591237,
0.0004103547,
-0.011332911,
0.016419336,
0.014401241,
0.009527609,
0.005594381,
0.019741643,
0.02204804,
-0.011449604,
0.044370648,
0.01732542,
0.018135404,
-0.027663013,
-0.030092964,
0.038494833,
-0.0013771444,
0.02090857,
-0.0100287,
0.019082673,
0.0057831486,
-0.026029317,
-0.011916375,
-0.0050006215,
0.030285165,
0.0149503825,
0.013035251,
-0.0030168472,
0.004609358,
-0.0030580328,
0.006912321,
0.016062394,
-0.001037363,
0.0033995302,
0.02042807,
-0.01478564,
0.01685865,
-0.0060542873,
0.007790948,
-0.007921369,
-0.0028435243,
0.0025106072,
-0.009225581,
-0.017668635,
-0.02296785,
-0.011257404,
0.0030202793,
-0.022157867,
-0.019549444,
0.0033394678,
-0.018931659,
-0.027580641,
-0.04118563,
0.014799369,
0.004228391,
-0.026509816,
-0.023256151,
-0.008951009,
0.02542526,
0.011641804,
0.007887048,
0.00031554195,
-0.013062708,
0.014854283,
-0.018121677,
-0.0146895405,
-0.0041322913,
-0.049285468,
-0.0014457871,
0.012637123,
0.0027268317,
-0.005213414,
-0.015870195,
-0.023668006,
0.019096402,
-0.011429012,
-0.0141678555,
-0.0027371282,
0.021251783,
0.012513567,
0.013296093,
-0.0006735566,
0.012513567,
-0.026702015,
0.0037650527,
-0.025191875,
-0.005546331,
-0.023956306,
0.025027134,
0.010317,
-0.013852099,
-0.017737277,
0.024464263,
-0.022665823,
0.01875319,
-0.021402797,
-0.00082414155,
-0.018917931,
0.0064077973,
-0.003061465,
0.016021209,
0.008799995,
0.020606542,
-0.00071474223,
0.00036294834,
-0.005261464,
0.010625891,
0.009280494,
0.0040670806,
0.005350699,
0.009850229,
-0.0093148155,
-0.022267696,
-0.020126043,
-0.0057419627,
0.01864336,
-0.013529479,
-0.004599062,
-0.04228391,
-0.0054776883,
-0.01921996,
0.02156754,
-0.012609666,
-0.015046482,
-0.010275814,
-0.0020215278,
-0.0047226185,
-0.0061847083,
0.012424331,
-0.02740217,
-0.022061767,
0.0008803428,
-0.0057522594,
0.031905133,
-0.008587203,
-0.014037435,
0.0030597488,
-0.021718554,
-0.011003426,
-0.043272365,
0.009726672,
0.014552255,
0.035913866,
0.006929482,
0.047390927,
0.012335096,
0.00809984,
0.028555367,
-0.013907013,
-0.0021999988,
-0.020853655,
-0.009699215,
-0.02042807,
0.02383275,
0.006919185,
-0.005457096,
-0.005436503,
-0.007969419,
0.00899906,
0.034129158,
-0.005597813,
-0.0057076416,
0.0025226197,
-0.034403726,
-0.009074567,
0.0145797115,
-0.0026255837,
0.015883923,
-0.03701215,
0.0052271425,
0.030285165,
-0.0024248038,
0.014044299,
-0.0014054595,
0.03174039,
0.0007705144,
-0.002148517,
0.0124517875,
-0.006102337,
-0.033744756,
-0.016048666,
-0.02542526,
0.0043141944,
0.03239936,
0.016282052,
0.02523306,
-0.00029730875,
-0.0020232438,
0.017572533,
0.031410906,
0.0058071734,
0.011374097,
0.01959063,
-0.022816837,
-0.013117623,
-0.0014243362,
-0.016158495,
-0.012547888,
0.0032038987,
-0.0036861135,
-0.005350699,
0.01788829,
-0.025493903,
-0.023489537,
0.03382713,
0.016968478,
0.011888918,
0.003138688,
0.042833053,
-0.0064936006,
-0.008243989,
-0.03860466,
0.0051756604,
0.009616844,
-0.020043671,
-0.004877065,
0.015458339,
-0.015952567,
-0.032426815,
0.030092964,
0.007674255,
-0.011662397,
-0.059362218,
0.015197496,
0.0039057704,
-0.005793445,
-0.038385004,
-0.013694221,
-0.030587193,
0.023379708,
-0.0042901696,
-0.004252416,
-0.008168482,
0.008607796,
-0.005899841,
0.018409975,
-0.021402797,
0.02995568,
0.008724488,
0.002153665,
-0.003950388,
0.008827453,
-0.0133716,
-0.0011866608,
0.02280311,
0.018808102,
-0.010907327,
-0.011991882,
0.0022154434,
0.020881113,
-0.014936654,
0.0012021055,
-0.024079863,
0.033195615,
-0.004273009,
-0.025768474,
-0.004279873,
0.0110308835,
0.0076879836,
0.008861774,
-0.0050212145,
-0.013097029,
-0.012190945,
-0.0064489827,
0.048242096,
-0.011936967,
-0.003933227,
-0.021485168,
-0.011312319,
-0.013598121,
-0.019535717,
-0.012431195,
0.0073241773,
-0.04236628,
-0.0069569387,
0.019576902,
-0.00790764,
0.019824015,
0.009582522,
-0.0023698895,
0.007770355,
0.03802806,
-0.021100769,
0.027017772,
0.029159423,
-0.002151949,
-0.04475505,
0.0063014007,
-0.014662083,
-0.02637253,
0.0335251,
-0.0050246464,
-0.034431186,
-0.020400614,
0.0101248,
0.0028950064,
0.017215593,
-0.013110758,
-0.002864117,
0.017037122,
0.0051001534,
-0.013570664,
-0.02241871,
0.012012474,
-0.009857093,
-0.010893598,
0.027539456,
-0.028335711,
0.025178147,
-0.027264886,
0.00602683,
-0.005034943,
-0.027855212,
-0.012705766,
0.0046677045,
0.013399057,
-0.015842738,
0.008916688,
-0.012444924,
-0.0053060814,
-0.006383772,
0.013570664,
0.0075781555,
0.0064833043,
0.011470197,
-0.0200574,
-0.019000303,
0.013536342,
-0.011545704,
-0.013687356,
0.0015890788,
-0.0145797115,
-0.042640854,
-0.014305141,
-0.01799812,
0.012575345,
0.03533727,
-0.008765674,
-0.030834306,
-0.007914505,
-0.04557876,
-0.01949453,
0.012060524,
-0.006658343,
0.03379967,
0.036215894,
-0.0067475787,
0.0103238635,
-0.019604359,
0.013989384,
-0.014552255,
0.0021176278,
-0.0037101386,
-0.0007996876,
0.036215894,
-0.022130411,
-0.046841785,
-0.021059584,
0.0017864265,
-0.002174258,
0.009520744,
0.03165802,
-0.007317313,
-0.007818405,
-0.00053841627,
0.01912386,
0.01478564,
0.011834003,
-0.0034990623,
-0.009726672,
0.009973786,
0.01063962,
0.012204674,
-0.0010416531,
0.0049285465,
0.008278311,
-0.020839928,
0.010818091,
-0.006174412,
-0.002682214,
0.014716998,
0.012287046,
0.014009978,
0.022995308,
0.021691097,
0.022940394,
0.018492347,
-0.0049045216,
-0.015224953,
-0.008628389,
0.002181122,
0.028280796,
-0.0068677035,
-0.009870822,
0.0048221503,
0.0064695757,
0.011092662,
-0.009966922,
-0.0019099835,
-0.01544461,
-0.014099213,
-0.028019955,
0.01761372,
0.024189692,
-0.011882054,
0.007207485,
0.0141678555,
-0.019631816,
0.015499524,
0.013742271,
0.017654905,
-0.036984693,
0.018217776,
-0.012595938,
-0.0037375956,
-0.012849916,
0.0040155984,
-0.024807476,
-0.031355992,
0.00861466,
0.19582392,
-0.0033394678,
-0.0017443829,
0.017847106,
0.0035625568,
0.012547888,
0.03088922,
-0.008964738,
-0.0073447702,
-0.009726672,
0.016721364,
-0.00091294805,
0.029351624,
0.0029310437,
0.024121048,
-0.0044514798,
-0.020386886,
-0.032536644,
-0.01684492,
0.030285165,
0.016597807,
-0.009781586,
-0.01799812,
-0.017201863,
0.03750638,
-0.016556622,
-0.016172223,
-0.005391885,
0.03720435,
0.028088598,
-0.014236499,
-0.00339095,
0.020084858,
-0.013536342,
-0.015526981,
0.015005297,
0.027484542,
0.013865828,
0.0034029623,
0.0134951575,
-0.027360985,
-0.013879556,
-0.014552255,
-0.011943832,
-0.00063880626,
0.007921369,
-0.0037856456,
-0.010056158,
-0.0027731655,
0.0071937563,
-0.009658029,
-0.030285165,
0.021032127,
0.01668018,
-0.02052417,
0.005213414,
0.009802179,
0.0050452393,
-0.009925736,
-0.0020867384,
-0.015211225,
0.0032759735,
-0.0012132599,
-0.00960998,
-0.025823388,
0.018039305,
-0.009246173,
0.02317378,
-0.0034544445,
-0.0058826804,
0.008092975,
-0.010632756,
-0.0058106054,
0.002682214,
-0.00960998,
-0.021869568,
0.014195313,
-0.00536786,
0.007262399,
0.030202793,
0.00032862698,
0.0036586565,
0.005360996,
-0.01733915,
0.008106704,
-0.029736023,
0.016021209,
0.00081684825,
-0.010227764,
-0.0058311983,
-0.023558179,
0.013474564,
-0.002400779,
-0.036133524,
0.008834317,
-0.0006370902,
-0.0004633383,
0.018423704,
-0.0028297957,
-0.01875319,
-0.010838684,
0.05593008,
0.04945021,
0.005168796,
0.0032244914,
0.0060954727,
-0.024354434,
0.023668006,
-0.01214976,
-0.0051482036,
0.009060838,
-0.032783758,
0.017778462,
-0.0024453965,
-0.003517939,
0.0329485,
0.022487352,
-0.007626205,
0.031026505,
-0.011003426,
0.009870822,
-0.015156311,
0.002407643,
0.022610908,
-0.007543834,
-0.0054845526,
-0.03654538,
0.015677996,
-0.02769047,
-0.02638626,
-0.001444929,
-0.009088295,
-0.00013106468,
0.016556622,
0.011916375,
-0.0072692633,
-0.017201863,
-0.019659273,
-0.014373784,
-0.012891102,
0.03635318,
0.0038611526,
0.013440243,
0.001593369,
-0.01190951,
-0.00006392352,
0.005652727,
0.012746952,
-0.011854596,
-0.031987503,
0.0010056157,
-0.013653035,
-0.009431508,
-0.00739282,
0.019549444,
-0.0061092013,
-0.00091209,
-0.0075026485,
-0.007337906,
0.0033720732,
-0.009905144,
0.0011823707,
0.06216284,
-0.010330728,
-0.017737277,
0.002606707,
-0.17539586,
0.012204674,
0.007887048,
-0.035145067,
0.023146322,
0.0068471106,
0.025356617,
0.024711376,
-0.012225267,
0.00094726944,
0.013893285,
0.006737282,
-0.033113245,
-0.01658408,
0.005920434,
-0.013604986,
-0.017160678,
0.028225884,
0.027182514,
0.016556622,
0.030202793,
-0.024423078,
0.013550071,
-0.01243806,
0.009596251,
0.0018018712,
-0.009857093,
0.009088295,
-0.012424331,
-0.030779392,
0.0058106054,
-0.015019026,
0.019604359,
-0.009678623,
-0.005316378,
-0.005264896,
-0.021045856,
-0.023942579,
-0.02269328,
-0.008209668,
0.016254595,
0.018629631,
-0.007207485,
-0.015128854,
0.0027800298,
0.015458339,
0.0061606835,
-0.023420893,
0.023256151,
-0.009637437,
-0.015307325,
-0.016982207,
0.024793748,
-0.0034287034,
-0.009452102,
0.0026530407,
0.008690167,
0.024272062,
0.009555065,
-0.010303271,
-0.03454101,
-0.011422147,
-0.004180341,
-0.0009824488,
-0.023118865,
-0.033415273,
-0.00374446,
0.008415597,
-0.003215911,
0.008127297,
-0.021141956,
0.011724175,
-0.008834317,
-0.0003187596,
-0.0029893902,
0.0006885722,
-0.0076536625,
0.01412667,
0.002455693,
-0.0026753496,
-0.009060838,
0.010104207,
-0.005532603,
-0.014250227,
0.009150074,
-0.005285489,
-0.00016474251,
-0.009349138,
0.008937281,
-0.019329788,
0.025411531,
-0.039785314,
-0.016227137,
-0.0050315107,
0.024052406,
0.008848046,
-0.0035316674,
0.0023235558,
0.014469883,
-0.023571907,
-0.009630572,
-0.010008107,
-0.047418386,
0.010776905,
0.022761922,
0.0014569416,
0.016735094,
0.02749827,
0.009850229,
-0.00068685616,
-0.01912386,
-0.015156311,
0.021718554,
0.0028435243,
-0.025782203,
0.017215593,
-0.0030185631,
-0.022734467,
0.011188762,
-0.004437751,
0.059472047,
-0.009616844,
-0.013522614,
-0.0014097497,
0.014373784,
-0.015485796,
-0.111915074,
-0.009301088,
0.023956306,
0.01761372,
0.0016602955,
0.005652727,
-0.0030769096,
0.01724305,
-0.024574092,
0.037835862,
-0.0344861,
-0.045441475,
0.004300466,
-0.002889858,
-0.006651479,
-0.0061641154,
0.0024265198,
-0.015980024,
0.019082673,
0.016433066,
0.018876746,
-0.016721364,
0.0070496066,
-0.014236499,
-0.010824956,
0.027072685,
-0.026345072,
0.033497643,
-0.0038028061,
0.026441172,
0.022253968,
-0.01902776,
0.014442426,
-0.011614347,
0.002858969,
0.0056046774,
-0.026784386,
-0.022267696,
0.009822772,
-0.0018842424,
0.00612293,
0.0043347874,
0.007282992,
0.009788451,
-0.0015007013,
-0.015019026,
-0.026290158,
0.03673758,
0.011785953,
-0.034870498,
-0.03588641,
-0.021141956,
-0.013968792,
-0.003747892,
0.002783462,
0.009349138,
0.007962555,
-0.00871076,
-0.021389069,
0.016007481,
0.0041940697,
0.003933227,
0.0037067065,
0.005292353,
-0.0019563173,
-0.0024488287,
-0.04266831,
-0.013852099,
0.0005542899,
-0.004025895,
-0.005137907,
0.016062394,
-0.018821832,
0.021649912,
-0.017833376,
0.00628424,
-0.02269328,
0.00790764,
0.01629578,
-0.024134777,
-0.02184211,
-0.014607169,
0.012431195,
-0.009445237,
0.028225884,
-0.009383459,
-0.025727289,
0.0049491394,
0.010996562,
-0.03599624,
0.038659576,
0.01724305,
-0.010907327,
-0.018300148,
-0.018039305,
0.008271446,
-0.014511069,
0.0061881403,
0.0037513243,
-0.013048979,
-0.035831496,
-0.009383459,
-0.062382497,
-0.0010845548,
0.037149437,
-0.017737277,
-0.021622455,
-0.016913565,
0.016089851,
-0.0050761285,
-0.0048804968,
-0.004664272,
-0.0048804968,
0.01825896,
-0.013907013,
-0.001468096,
-0.027017772,
-0.019357245,
0.011374097,
0.0016268323,
0.022185324,
0.018341333,
-0.0015985172,
-0.0053129457,
0.008024333,
0.048242096,
-0.014360055,
0.011072069,
-0.016529165,
0.02081247,
0.0059890766,
-0.00089321326,
0.022171596,
-0.01959063,
-0.018451162,
0.031191248,
-0.016007481,
-0.021443984,
0.0021794061,
0.009102023,
0.02100467,
0.033195615,
-0.0093148155,
0.0002962362,
0.014099213,
-0.006435254,
-0.017723547,
0.015321054,
0.008621525,
-0.0052065495,
0.011113255,
-0.016172223,
0.021608725,
0.008518561,
0.004448048,
-0.041268,
-0.005439935,
-0.020661457,
0.019796558,
0.016872378,
0.0005980496,
-0.013632443,
0.041981883,
0.024079863,
0.032262076,
0.0012424331,
0.014277684,
-0.004739779,
-0.031493276,
0.013241179,
-0.0034458642,
-0.0030906382,
-0.024121048,
-0.016803736,
0.00904711,
-0.00042322522,
0.023338523,
-0.003895474,
0.003668953,
-0.0008172773,
0.01026895,
0.015307325,
0.007935097,
-0.0059067053,
-0.0014964112,
0.032838672,
0.018725732,
-0.00647644,
-0.0010236345,
0.028390625,
0.00080097467,
0.0146895405,
-0.011429012,
-0.0069535067,
-0.005872384,
-0.0036449279,
-0.01517004,
0.03042245,
-0.012472381,
0.02534289,
0.034266442,
0.02872011,
0.0012613098,
0.006627454,
0.004554444,
-0.0153622385,
-0.037726033,
0.019906387,
-0.035666753,
-0.020730099,
-0.0108455485,
0.008278311,
0.011868325,
-0.00202496,
0.01190951,
0.0120399315,
-0.021251783,
0.0070221494,
-0.0023287039,
-0.010440556,
-0.020400614,
-0.022020582,
0.002004367,
0.018657088,
0.026509816,
-0.02335225,
0.009280494,
-0.012232131,
0.030477364,
-0.013035251,
0.013488293,
-0.0009386891,
0.017133221,
-0.0006555379,
-0.012630259,
-0.0035625568,
-0.013083301,
-0.011470197,
0.011339776,
0.0071594347,
0.004808422,
0.0879725,
0.017737277,
-0.0075369696,
0.011257404,
-0.035804037,
-0.0012535875,
0.03651792,
-0.0022446166,
0.002985958,
-0.038412463,
0.0052992175,
0.003823399,
0.018190319,
-0.015980024,
0.0039400915,
-0.0069569387,
-0.009156938,
0.024560362,
-0.0027542887,
0.014895468,
0.02372292,
-0.008189076,
0.03152073,
0.059636787,
-0.007694848,
-0.010673942,
0.017119491,
-0.024079863,
0.017297963,
-0.03868703,
0.009946329,
0.0049182503,
-0.041130714,
-0.0131588075,
-0.0128224585,
-0.0068402463,
0.006785332,
-0.029873308,
0.008388139,
0.012987201,
0.025686102,
0.009005924,
-0.015732909,
-0.0016053814,
-0.015883923,
-0.0201535,
-0.005927298,
-0.032344446,
-0.010275814
] |
CONTEXT Early childhood introduction of nutritional habits aimed at atherosclerosis prevention is compatible with normal growth, but its effect on neurological development is unknown. OBJECTIVE To analyze how parental counseling aimed at keeping children's diets low in saturated fat and cholesterol influences neurodevelopment during the first 5 years of life. DESIGN Randomized controlled trial conducted between February 1990 and November 1996. SETTING Outpatient clinic of a university department in Turku, Finland. PARTICIPANTS A total of 1062 seven-month-old infants and their parents, recruited at well-baby clinics between 1990 and 1992. At age 5 years | [
0.004547638,
-0.00032624358,
0.013240876,
-0.03498386,
-0.0072103124,
0.0027137534,
-0.004010489,
0.0025885287,
-0.022514103,
-0.011975446,
0.009180956,
0.013214513,
-0.016674671,
0.014236083,
-0.024570426,
0.013161786,
0.03704018,
-0.020563232,
0.009886169,
-0.00029576122,
-0.028023994,
0.014091087,
0.0002380919,
-0.03424569,
-0.0022309788,
-0.011224098,
0.011652498,
-0.040783744,
-0.02460997,
-0.021195946,
0.021855025,
-0.009444587,
0.014710619,
-0.013603369,
-0.015448786,
-0.01488198,
-0.007770529,
-0.0076914397,
0.011889766,
0.00019514885,
0.008152794,
0.001096541,
-0.0071180416,
-0.0019887676,
-0.00794848,
0.0073355376,
-0.0010998363,
0.003390956,
-0.017228298,
0.015686056,
0.029553054,
0.012199532,
-0.0076387133,
0.0062118093,
-0.019719612,
0.017030574,
-0.023304995,
0.024583606,
0.00964231,
-0.029922139,
0.008152794,
0.012199532,
-0.011797495,
-0.0007789477,
-0.012621342,
0.0013577006,
-0.020207329,
0.031029388,
-0.0020431415,
0.03313844,
0.009121639,
0.044790935,
-0.014222902,
0.00024468268,
0.003687541,
0.02014142,
-0.0063963514,
-0.013405645,
0.0072169034,
0.0043004835,
0.0059910184,
-0.011362503,
0.0074607623,
0.04877177,
0.01852009,
-0.0062744217,
0.013550642,
0.018216914,
-0.011131826,
-0.011487728,
-0.0050089923,
0.016028775,
0.01911326,
-0.00469593,
0.0027829565,
0.0037732213,
-0.010182754,
0.02409589,
-0.004303779,
0.015448786,
-0.016345132,
-0.010881376,
-0.0005606282,
-0.006571007,
-0.022461375,
-0.004142305,
-0.021525485,
0.004541047,
0.01023548,
-0.030581215,
-0.02343681,
0.024399064,
-0.014710619,
-0.020115059,
0.022632737,
0.00054785854,
-0.0017103072,
0.014578803,
-0.0065347576,
-0.0039050367,
0.017109662,
0.016371496,
0.029974865,
-0.00031738722,
0.0037995842,
-0.0036908365,
-0.025414046,
-0.017241478,
-0.026969468,
-0.01318815,
-0.018071918,
-0.007111451,
0.016964667,
0.014644711,
-0.03340207,
0.014420625,
-0.026455387,
0.007618941,
-0.03189937,
-0.02731219,
0.009925714,
0.015738782,
-0.015923323,
-0.009088685,
-0.010789106,
0.029394876,
0.010097074,
0.060266085,
-0.010387069,
-0.028050357,
0.0055197775,
-0.006613847,
0.0153696975,
0.015211519,
0.011052737,
0.040467385,
-0.003493113,
0.028393077,
-0.03653928,
0.0006875007,
0.00060388015,
-0.026929924,
-0.012146806,
0.010294797,
0.0062085143,
0.00972799,
0.018282821,
-0.00888437,
0.033217527,
-0.014657893,
-0.009589584,
0.028551256,
-0.028313989,
-0.0009251807,
-0.00040080177,
0.0016617002,
-0.0013296898,
0.014104268,
-0.015936505,
-0.020457778,
-0.023318177,
0.001187988,
0.018665086,
0.021380488,
0.0015694293,
-0.0022425128,
0.02638948,
-0.001619684,
0.0027088104,
0.0018223504,
0.002829092,
0.01623968,
-0.03179392,
-0.03308571,
-0.65844524,
-0.006188742,
0.006636915,
-0.013168377,
0.03018577,
0.04120555,
0.008152794,
0.0016781772,
0.00030811894,
0.018335547,
0.011540455,
0.017623743,
0.011626135,
-0.0071773585,
-0.0104397945,
-0.024557244,
-0.004442185,
-0.0108352415,
0.031240294,
-0.0068544103,
0.005605458,
0.021617755,
-0.013352919,
0.0024319976,
0.024979053,
0.03880651,
0.013484734,
-0.010980238,
0.0069071366,
-0.00035651997,
0.0052198973,
0.01142182,
0.012173169,
0.027786726,
0.04877177,
-0.020391872,
-0.012990426,
0.019390073,
0.0020546755,
0.021248672,
-0.048349958,
-0.02918397,
0.024596788,
0.014684256,
-0.017360114,
0.020444598,
0.016621945,
0.011237279,
0.000035348203,
-0.0036348149,
0.0037567443,
-0.00930618,
-0.01251589,
-0.016437404,
0.011065919,
-0.021169582,
0.03232118,
-0.01853327,
0.007849618,
0.029737595,
-0.010650699,
0.010090483,
-0.021815479,
0.0028917044,
-0.020167785,
0.04025648,
-0.023529083,
0.009998213,
-0.019007808,
-0.015976049,
0.02156503,
0.033032987,
0.006732481,
-0.019469162,
0.025796311,
-0.005457165,
0.04025648,
0.023990437,
-0.017571017,
0.011942492,
-0.015066521,
0.014829254,
-0.010901149,
0.022224108,
0.007651895,
-0.0104200225,
-0.016002413,
0.011652498,
-0.021499122,
-0.023990437,
0.004863995,
0.0010298092,
-0.0056647747,
-0.050933544,
-0.0024369406,
0.03237391,
-0.013748365,
-0.0022309788,
0.023542264,
0.0041950312,
-0.0083966525,
0.025414046,
-0.011645908,
0.001695478,
0.020286418,
0.0046464996,
-0.02097186,
0.010538656,
0.02486042,
-0.028683072,
0.0088118715,
0.016951485,
-0.032663904,
-0.010294797,
-0.0013057982,
-0.020418234,
-0.012443392,
-0.002397396,
0.0025769947,
-0.025835855,
0.017650107,
-0.0080077965,
0.012812475,
0.0048277457,
0.0088118715,
0.009569812,
-0.014183357,
0.0035787933,
-0.0062480588,
-0.03308571,
0.000631479,
0.03461477,
0.018915536,
-0.013919726,
0.01150091,
0.020325964,
0.012074308,
-0.0030202246,
-0.016279224,
-0.025664495,
-0.011566818,
-0.00017311094,
0.009820261,
-0.012871792,
-0.0035886792,
-0.016977848,
0.031477563,
0.0042905975,
-0.012351121,
-0.003018577,
-0.0067621395,
0.0096225375,
-0.023357721,
0.009569812,
0.0013403997,
-0.008086886,
-0.0064227143,
-0.026771747,
-0.004768429,
-0.0025506315,
0.0017663288,
0.012614751,
-0.022817278,
0.0124829365,
-0.008864598,
0.0100443475,
-0.0076321224,
0.0056482977,
0.0039314,
-0.01861236,
-0.012674069,
-0.03002759,
-0.012627933,
-0.0015990878,
-0.012713613,
0.011724996,
-0.01420972,
0.0020003016,
-0.017702833,
0.0057471595,
0.012990426,
-0.019970061,
-0.018361911,
0.00039441694,
0.038780145,
0.010617745,
0.030923937,
0.019666886,
-0.008877779,
0.028551256,
0.0041488954,
0.026112668,
-0.025875399,
-0.004498207,
-0.002198025,
-0.024926327,
-0.008080295,
-0.001641104,
0.0078100734,
0.012562025,
0.035458393,
-0.019548252,
0.025743583,
0.0011624487,
0.019943697,
-0.018045554,
0.009721399,
-0.01057161,
0.002018426,
-0.0011599772,
-0.00032418396,
-0.017571017,
-0.0024336453,
-0.0128981555,
-0.0053978483,
-0.008165976,
-0.011784313,
-0.010578201,
-0.023884984,
-0.0024418838,
0.0072564483,
-0.025361318,
0.017729197,
0.00040265542,
-0.0037864028,
0.042681888,
0.016766943,
0.007843028,
-0.015791507,
-0.027074922,
0.01057161,
-0.010288207,
-0.024372702,
0.0096357195,
-0.004929903,
0.025769947,
0.012258849,
-0.027101284,
-0.00066731643,
0.024385884,
0.019495524,
0.016674671,
0.023423629,
0.009503904,
0.0067687305,
-0.0062447633,
0.025598587,
0.021116856,
-0.02588858,
-0.0021123448,
0.008139612,
0.009872988,
-0.022527283,
-0.013346328,
-0.0005836959,
0.008943687,
0.0025341546,
-0.0039907168,
0.018704632,
0.030396674,
0.042075533,
0.009490722,
-0.010518883,
-0.00006111918,
0.012693841,
-0.017267842,
-0.012469755,
-0.003305276,
-0.018322367,
-0.016107865,
-0.030159406,
-0.012983835,
0.0070455433,
-0.04726907,
0.004175259,
0.012535662,
0.011988628,
0.0062118093,
0.022290016,
0.01378791,
-0.0071839495,
-0.0028208536,
0.02317318,
0.03754108,
-0.0044125267,
0.004936494,
-0.001403836,
-0.014222902,
-0.0064029424,
0.004221394,
0.008093477,
0.017478747,
-0.010756152,
-0.016556038,
-0.02698265,
-0.010321161,
0.006781912,
-0.007941889,
0.008554831,
-0.028814888,
0.003526067,
-0.008851416,
-0.010828651,
-0.016582401,
0.023542264,
0.017122844,
0.008956869,
-0.013148605,
0.009886169,
-0.015831051,
0.026719019,
-0.0011698634,
-0.0017103072,
0.013464962,
0.006900546,
0.015910141,
-0.0033728313,
-0.0022194448,
0.0054242113,
0.0013782968,
-0.012449983,
-0.045107294,
-0.023621352,
-0.007111451,
0.05826249,
0.0066863457,
0.025598587,
0.031978462,
0.032400273,
0.0021189356,
-0.010505702,
-0.015237882,
0.007203722,
0.01150091,
0.010209117,
-0.0027681272,
0.018599179,
-0.011771132,
-0.0073619005,
0.010499111,
0.0053253495,
-0.008838235,
-0.006814866,
-0.0072959927,
-0.000988617,
0.000109880646,
0.030818485,
0.037356537,
0.03087121,
-0.010479339,
0.017821467,
0.03408751,
0.0006005848,
-0.011210916,
-0.014723801,
0.01099342,
-0.003921514,
0.019838246,
-0.0039017415,
0.015000613,
0.0070719062,
0.0030119861,
0.0066962317,
0.011626135,
0.03949195,
-0.009820261,
-0.0016592287,
-0.004887063,
0.0027401166,
-0.00020215155,
0.023028184,
0.025387682,
-0.014512897,
-0.025717221,
0.028762162,
0.0019245076,
0.0072234944,
-0.0031438018,
0.029526692,
-0.026626749,
0.014829254,
0.0070125894,
0.00053426507,
-0.0084098345,
-0.0005738097,
-0.009517086,
0.0014425569,
-0.011342731,
-0.0141174495,
-0.019640522,
-0.022105474,
0.002736821,
-0.00032686145,
0.017716015,
-0.0017020687,
-0.00091529445,
-0.030581215,
0.0012448335,
0.0110791,
0.008943687,
0.015883777,
-0.0145392595,
-0.00202996,
0.036143836,
-0.0035656116,
-0.0083900625,
0.0060338583,
-0.002878523,
0.020853225,
0.021011405,
0.00046629764,
-0.026824472,
0.005579095,
0.011210916,
-0.004873881,
0.007704621,
0.023463175,
-0.012291803,
-0.036565643,
-0.01834873,
0.004442185,
0.012753158,
0.010512293,
-0.024109071,
-0.03653928,
0.0053088726,
-0.008080295,
-0.0065018036,
-0.017307386,
0.01252248,
-0.02638948,
-0.011830449,
0.0108747855,
-0.018559635,
0.028182173,
-0.009484132,
-0.02106413,
-0.011698633,
0.0055692084,
0.021459578,
0.02097186,
0.012272031,
0.012983835,
-0.00046670955,
0.023581808,
-0.0057636364,
0.02122231,
-0.007170768,
-0.017136026,
0.011046146,
0.020167785,
-0.009424814,
-0.01733375,
0.0027467073,
-0.003812766,
0.021525485,
-0.0116656795,
-0.045133658,
-0.025980853,
-0.0040632156,
-0.012120443,
-0.016701035,
-0.01741284,
-0.021525485,
0.008594376,
-0.007487125,
0.0015488331,
-0.026429025,
0.04779633,
-0.02799763,
-0.005262737,
-0.011309777,
-0.019890971,
0.029421238,
-0.017465565,
-0.00033407012,
-0.026442207,
0.010986829,
-0.0018157597,
-0.015501513,
0.016977848,
0.0010940693,
0.037910163,
-0.0023990436,
0.029394876,
-0.013392463,
-0.00435321,
-0.0020991631,
0.01116478,
-0.021248672,
-0.008561422,
0.02613903,
-0.013240876,
0.010512293,
0.016991029,
0.0014260799,
-0.0022507512,
-0.020905953,
-0.0013980691,
0.016463766,
0.004692635,
-0.022896368,
-0.008581195,
-0.034140237,
0.013524279,
0.012120443,
-0.0070850877,
0.023186361,
-0.01175795,
-0.009490722,
0.02131458,
0.008535059,
0.017571017,
-0.0062645357,
0.010683653,
-0.03282208,
0.013214513,
-0.014315173,
0.006079994,
0.0137220025,
-0.026534477,
-0.007447581,
-0.009958668,
0.0038753783,
0.010815469,
0.01446017,
0.01817737,
0.00355243,
-0.014908343,
0.0050221737,
-0.021499122,
-0.006755549,
-0.005799886,
-0.012285213,
-0.0078628,
-0.008126431,
0.0116854515,
-0.011593181,
-0.002736821,
-0.005938292,
-0.026784927,
0.010749561,
-0.026363118,
0.008950278,
-0.020905953,
-0.023449993,
0.032742992,
-0.04102101,
0.027074922,
0.0051968293,
0.00043952258,
-0.02493951,
0.01961416,
0.005242965,
0.0046497947,
0.03358661,
0.0007628827,
0.011896357,
0.006310671,
-0.027813088,
0.030001227,
-0.016872395,
-0.030633943,
0.012878383,
0.009602766,
-0.0043334374,
-0.0011789256,
-0.022382287,
-0.045871824,
0.021485941,
-0.0027219919,
-0.01403836,
0.00059152243,
-0.018032372,
-0.008943687,
0.062058777,
-0.022711826,
0.029922139,
-0.0021255263,
0.0033118667,
0.008554831,
-0.03408751,
-0.013735184,
0.0141438125,
0.023871804,
0.027523095,
0.0013272181,
0.020866407,
0.0073684915,
0.0047387704,
-0.00082096393,
0.009497313,
-0.020049151,
0.028551256,
0.0076650763,
-0.021841843,
0.014288809,
-0.0025473363,
0.021037767,
-0.007618941,
-0.0149478875,
-0.040625565,
-0.04634636,
-0.010169572,
0.005473642,
0.0042905975,
-0.022184564,
0.0064754407,
-0.009675264,
0.011382276,
-0.0157256,
-0.02520314,
0.006027268,
-0.017399658,
-0.016951485,
-0.007137814,
-0.0013247466,
-0.018243277,
0.012417029,
-0.0035886792,
-0.012120443,
0.021947294,
-0.013985634,
0.019139623,
0.010505702,
0.03340207,
-0.015106066,
0.009688445,
-0.038015615,
0.0010759447,
0.010723198,
0.00912823,
-0.029210335,
-0.0137220025,
0.013511098,
0.026323572,
0.007315765,
-0.00020699167,
0.016674671,
0.0005981132,
-0.01691194,
-0.0058130673,
-0.021841843,
0.013590187,
-0.01717557,
-0.01091433,
0.012127034,
-0.0124895265,
0.011810676,
-0.0014573861,
0.013221104,
-0.0023248973,
-0.034852043,
0.01664831,
-0.0104200225,
0.021459578,
-0.02070823,
0.006900546,
-0.024596788,
0.003763335,
-0.0055527315,
0.0044553666,
-0.0074541713,
-0.025651313,
0.020932315,
0.014011997,
0.004583887,
0.0063205576,
-0.003493113,
-0.015620147,
0.0046563856,
-0.020154603,
-0.034430232,
0.003796289,
-0.015145611,
0.026587203,
0.028445804,
-0.024319977,
0.005124331,
-0.014288809,
-0.033612974,
0.005216602,
-0.0035754978,
0.0028175581,
0.0038424244,
-0.007724393,
-0.0012588388,
0.017030574,
-0.02841944,
0.015171974,
-0.0100245755,
0.00541103,
0.009971849,
-0.008488924,
0.02055005,
0.0056812516,
-0.013102469,
-0.007197131,
0.014961069,
-0.014987432,
-0.018467363,
0.008469151,
0.010525474,
0.0005762813,
-0.022685463,
0.024201341,
0.025005417,
-0.011823858,
-0.00009973703,
-0.016714217,
0.015171974,
-0.0101498,
-0.0076387133,
-0.030554853,
-0.03279572,
-0.009596175,
-0.01547515,
-0.0016691149,
-0.041284643,
-0.005206716,
0.026059942,
-0.0047717243,
0.003921514,
0.002034903,
0.005473642,
0.0040632156,
0.018546453,
-0.017834648,
0.016885577,
-0.01049252,
-0.015237882,
0.0028603983,
-0.010591382,
-0.0070125894,
-0.013029971,
0.0019245076,
0.010077301,
-0.022949094,
0.014222902,
0.0048442227,
0.0068807737,
-0.018559635,
0.027364915,
-0.009536858,
-0.0065841884,
-0.017017392,
0.013748365,
-0.014275628,
0.008660284,
-0.020602776,
0.010505702,
-0.043156423,
-0.0006005848,
0.005091377,
-0.028630346,
0.0025522793,
0.0027335258,
-0.031503927,
-0.016055139,
0.011705224,
0.17842558,
-0.013221104,
-0.0000912411,
0.0037139042,
-0.013049743,
-0.0032113572,
0.03601202,
0.021683663,
-0.026099486,
0.01403836,
0.005793295,
0.009358907,
-0.011718405,
0.009405042,
0.028393077,
-0.016766943,
-0.022105474,
-0.02223729,
0.01691194,
-0.024122253,
0.0034733408,
-0.016898759,
-0.0050880816,
-0.006781912,
0.027206738,
0.018955082,
-0.031055752,
0.02384544,
0.025466772,
0.00076329464,
-0.011560227,
-0.00014386435,
-0.00045270415,
0.0063403295,
-0.010578201,
-0.012014991,
0.015738782,
0.001301679,
0.010479339,
0.0030927232,
0.02182866,
-0.004458662,
0.009141411,
-0.02122231,
-0.013115651,
0.018454183,
-0.00074846536,
-0.024662696,
-0.031978462,
0.011000011,
-0.029421238,
-0.014921525,
0.006376579,
0.0076782578,
-0.009405042,
0.008337336,
0.007467353,
0.023977255,
-0.0036414056,
0.021195946,
-0.010189345,
0.022171382,
-0.010288207,
0.024056345,
-0.0061261295,
0.026059942,
0.01133614,
-0.02325227,
-0.015686056,
-0.011296595,
0.023529083,
-0.012865202,
-0.03213664,
0.0015381231,
-0.011052737,
-0.012206123,
0.035221126,
0.011224098,
0.009787307,
0.026679475,
-0.018796902,
-0.0120611265,
-0.031503927,
0.024583606,
-0.025163595,
-0.052726235,
0.010907739,
0.003829243,
-0.0022968866,
-0.004863995,
0.015211519,
-0.0009787307,
-0.013300193,
0.0073223556,
0.026349936,
-0.019719612,
-0.01260157,
0.02231638,
0.010433204,
0.002899943,
-0.029895775,
0.062480588,
0.006887364,
0.021156402,
-0.006926909,
-0.004092874,
-0.017966464,
0.011876584,
0.0047486564,
-0.0067028226,
-0.001431023,
-0.010426613,
-0.00050295884,
-0.006564416,
-0.007869391,
0.024267249,
0.0061195386,
-0.0314512,
0.02690356,
-0.019917335,
0.005826249,
-0.009062322,
-0.00439605,
0.046794534,
-0.0208005,
-0.020180967,
-0.031741194,
-0.010347524,
-0.005134217,
-0.02097186,
0.0032064142,
-0.04676817,
-0.023898166,
0.017294206,
-0.025097687,
0.0024468268,
0.0010710016,
0.0096093565,
0.018361911,
0.01716239,
-0.0020035969,
-0.020945497,
0.007236676,
-0.008014387,
0.01124387,
-0.03891196,
0.015092885,
0.000458883,
-0.022870004,
0.0052396697,
-0.0035293624,
0.017346932,
0.004712407,
0.016793305,
-0.012113852,
-0.028551256,
-0.028313989,
-0.029157607,
-0.0060305633,
-0.0137220025,
-0.014354717,
0.02114322,
0.014842435,
-0.0071180416,
0.00069450337,
0.0033612975,
-0.1666149,
0.0043334374,
0.018230096,
-0.01073638,
0.018744176,
-0.004923312,
0.030396674,
0.025994034,
-0.016516494,
-0.0037237904,
0.025150415,
0.0070653153,
-0.025071325,
-0.011006601,
0.019917335,
-0.010472748,
-0.00075299654,
0.029737595,
-0.004313665,
0.014275628,
0.02367408,
-0.029737595,
0.019772338,
0.005506596,
0.013069515,
0.037013818,
-0.016134229,
-0.005051832,
-0.0044224127,
-0.014736983,
-0.005717501,
-0.0015768439,
0.021485941,
0.0157256,
-4.4893247e-7,
0.013827455,
-0.0044850255,
-0.004514684,
-0.021657301,
0.023265451,
0.0096159475,
0.029473966,
0.0028472166,
-0.007763938,
0.004211508,
-0.0032756173,
-0.0039874213,
-0.037303813,
0.015527876,
-0.014486533,
0.008067114,
-0.023054546,
0.013906544,
0.0068346383,
-0.007974843,
-0.00009644164,
-0.008508696,
0.024135433,
0.006953272,
-0.00046053072,
-0.008278019,
-0.013867,
0.015659692,
0.0056450027,
0.025348138,
-0.044105496,
-0.011929311,
-0.0061030616,
-0.024504518,
0.00083826476,
-0.02267228,
-0.012621342,
-0.0008914029,
-0.026626749,
0.011072509,
0.0026659702,
-0.008554831,
0.0030531785,
0.0054373927,
0.012977244,
0.0000015978135,
-0.009767535,
-0.03677655,
-0.00022799977,
-0.007724393,
0.015949685,
0.00591852,
0.0020365508,
0.019086897,
-0.008192339,
-0.0014013645,
-0.04244462,
-0.0028159104,
-0.0022326265,
0.014895162,
0.025440408,
0.0023150113,
0.007803483,
0.0015702532,
0.014789709,
0.00047906727,
-0.009800489,
-0.023542264,
0.014328354,
0.022000022,
-0.0044191177,
-0.02259319,
0.0153433345,
0.053648945,
-0.03213664,
-0.0007068611,
0.0087921,
-0.012014991,
-0.004152191,
-0.008027569,
0.030133042,
-0.0032920942,
-0.01285202,
0.0112702325,
-0.01852009,
0.03087121,
-0.0059152246,
-0.0020381985,
0.010742971,
0.007131223,
0.000037588037,
-0.116419524,
-0.035563845,
-0.0058031813,
0.004415822,
0.0058196583,
0.025994034,
-0.008508696,
-0.0011748064,
-0.004873881,
0.02453088,
-0.024293613,
-0.010868195,
-0.010433204,
-0.022883186,
0.03601202,
0.00888437,
0.0060701077,
-0.014736983,
-0.03651292,
0.04197008,
0.012443392,
-0.024504518,
-0.007348719,
-0.0052495557,
-0.006755549,
-0.012924518,
-0.02283046,
-0.0018223504,
0.004735475,
0.030423038,
0.015791507,
0.0028768752,
0.011804086,
-0.028603982,
-0.008067114,
-0.00074105075,
0.0066632777,
-0.0170833,
0.028683072,
-0.018651906,
0.01142182,
0.0058361352,
0.03798925,
-0.02799763,
0.014156994,
-0.011804086,
-0.027892178,
-0.0053813714,
-0.0036249286,
-0.00078595045,
-0.015567421,
-0.012298394,
-0.008660284,
0.013221104,
0.016727397,
-0.012304985,
0.012463164,
-0.01361655,
-0.006188742,
-0.0141174495,
0.000091653026,
0.008831644,
-0.023581808,
0.006722595,
0.017360114,
-0.010558428,
-0.028313989,
-0.023476357,
-0.00043622722,
-0.0110791,
-0.0071246326,
-0.0018783722,
0.01158659,
0.019732794,
-0.030660305,
-0.0020909247,
-0.023964074,
-0.018638724,
-0.0006817337,
-0.033059347,
-0.0051539894,
-0.02155185,
0.028683072,
-0.010097074,
-0.0021090494,
0.008014387,
0.009457768,
0.0011204325,
-0.010894558,
-0.02232956,
0.009800489,
0.028050357,
0.007974843,
-0.005793295,
0.0027994334,
0.01861236,
0.012166578,
0.0019854722,
0.040862832,
-0.0035919747,
-0.017109662,
-0.0032624358,
-0.044184584,
0.019086897,
-0.0022227403,
-0.009457768,
-0.0070850877,
-0.004033557,
0.022685463,
-0.033982057,
0.006544644,
0.017702833,
-0.018506909,
0.03155665,
-0.012931109,
0.0063370345,
-0.012397256,
-0.01970643,
0.01953507,
0.007908936,
0.02984305,
0.033955697,
0.03830561,
0.0047321795,
0.019047352,
0.024029981,
-0.0057471595,
0.0004465253,
0.013590187,
0.017215116,
0.018836448,
0.008165976,
0.019890971,
-0.03155665,
0.01446017,
0.02392453,
-0.0025308593,
-0.009246863,
0.006966454,
0.009016186,
0.02689038,
0.044711847,
-0.006020677,
-0.010426613,
-0.009009595,
-0.019337347,
-0.014091087,
0.0038687875,
-0.021604575,
0.011435002,
0.0016921826,
-0.02926306,
0.023304995,
0.014011997,
0.017861012,
-0.030554853,
-0.009958668,
0.03450932,
0.009563221,
0.0208005,
-0.017452383,
-0.025150415,
0.0044224127,
-0.016424222,
0.012707023,
0.0066435058,
0.019047352,
-0.024636334,
0.007902345,
0.021512304,
0.013379282,
-0.039755583,
-0.026560841,
-0.006300785,
0.0063864654,
0.0075398516,
0.00033077472,
-0.03247936,
-0.011606363,
0.017544655,
-0.016951485,
0.024122253,
0.005852612,
0.007434399,
-0.01666149,
0.02815581,
0.031530287,
0.0068610013,
-0.01768965,
0.008904143,
-0.00972799,
0.0004844223,
-0.023410449,
0.017887374,
0.018823266,
0.0014672723,
-0.0028389783,
0.015765144,
0.009180956,
-0.012594979,
0.0032591403,
-0.0026989242,
-0.0044092312,
-0.0009103514,
-0.0044784346,
-0.01243021,
-0.005994314,
-0.0033069234,
-0.014776527,
-0.03374479,
-0.00684782,
-0.009457768,
0.00093012373,
0.017874194,
0.009200728,
0.022777732,
-0.019482344,
0.022118656,
-0.022514103,
0.021130038,
-0.010301388,
-0.0033168097,
0.0021008109,
0.010729789,
0.019350529,
0.0008897552,
-0.011388866,
0.024227705,
0.038279247,
-0.008568013,
0.035906564,
0.000004695287,
0.00025580463,
0.0079814335,
-0.024662696,
-0.010973647,
0.0063732835,
-0.030739395,
0.017716015,
-0.002240865,
-0.015844233,
0.062006053,
-0.030923937,
-0.028366715,
-0.014354717,
0.014605167,
0.020905953,
0.0066566872,
-0.015435605,
0.0058328398,
-0.00060923514,
0.013036561,
-0.02807672,
0.010050938,
-0.03279572,
-0.008060523,
0.0046563856,
-0.005440688,
0.013853818,
0.014275628,
-0.008192339,
0.015923323,
-0.01741284,
0.0059317015,
0.020774137,
-0.026429025,
-0.008640512,
0.019218713,
-0.034298416,
0.012832248,
-0.025690857,
-0.025638131,
0.040704653,
-0.057577047,
-0.009695036,
0.010670472,
-0.019653704,
-0.011612954,
0.010881376,
0.003163574,
0.010551837,
0.00752667,
0.034192964,
-0.024899965,
-0.0028373306,
-0.022474557,
-0.016780125,
0.0076321224,
-0.013339737,
-0.020365508
] |
BACKGROUND The purpose of this study was to test the hypothesis that vasodilator responses of porcine coronary resistance arteries are increased by exercise training. METHODS AND RESULTS Yucatan miniature swine were randomly divided into groups of exercise-trained (ET) and sedentary (SED) control pigs. ET pigs were placed on a progressive treadmill training program lasting 16 to 20 weeks, and SED pigs remained inactive during the same time period. Coronary resistance arteries 64 to 157 microns in diameter were isolated for in vitro evaluation of relaxation responses to the endothelium-independent dilators sodium nitroprusside (1 | [
-0.030168185,
-0.026880283,
0.0025330272,
-0.018707495,
-0.022679819,
0.024733081,
-0.013688412,
-0.016050333,
-0.034113668,
-0.0106085185,
-0.026115341,
0.022800598,
0.015419593,
0.0038817383,
0.0019408691,
0.01206459,
0.024585461,
-0.0038750283,
0.007045506,
-0.021633059,
-0.017043414,
0.012608101,
-0.0024525071,
0.0053378097,
-0.013185161,
-0.004847979,
0.020572877,
-0.028718824,
-0.013809192,
-0.02292138,
-0.002944015,
0.005163349,
-0.0109977,
-0.016077174,
-0.017083675,
-0.01117216,
-0.016707914,
0.009461108,
0.026477681,
0.0032057052,
0.0116217295,
-0.013970232,
0.0035160428,
-0.008709587,
-0.0015013637,
-0.01266849,
0.020465517,
-0.017459435,
-0.014949893,
0.014533872,
0.02449152,
-0.012930181,
0.025511442,
0.014762012,
-0.007072346,
-0.0069247256,
-0.004784234,
0.03346951,
-0.002234432,
-0.02431706,
-0.007273646,
0.008018456,
-0.031859107,
0.032771666,
-0.03561671,
0.0012992248,
0.002863495,
0.017875455,
0.014023912,
0.008843787,
0.020143436,
0.019217456,
0.0152585525,
0.0014283925,
0.030087665,
-0.00574712,
-0.018465936,
-0.008300277,
0.008461317,
-0.004723844,
0.0065556755,
-0.037227113,
-0.024504941,
0.018935636,
0.020827858,
-0.0057538296,
-0.0055089146,
-0.013520662,
-0.017781515,
0.0120713,
0.029497184,
0.044769157,
0.010273019,
0.0037945083,
-0.013339492,
0.01210485,
-0.015634313,
0.024800181,
-0.01190355,
-0.018130435,
-0.009024957,
-0.01183645,
-0.0065892255,
-0.015486693,
-0.020559458,
-0.0020666816,
-0.02539066,
-0.021163357,
0.010769559,
-0.010158949,
-0.001211156,
0.032020148,
-0.019069836,
-0.021633059,
0.0232032,
-0.02482702,
0.0054887845,
-0.0020415192,
0.018586716,
-0.0066429055,
0.010132109,
0.008937728,
0.038783833,
-0.0057404097,
0.032637466,
-0.018640395,
-0.0029322724,
-0.0003946322,
0.0036938582,
-0.0006835818,
-0.017231295,
0.009991199,
-0.008246597,
-0.013507241,
-0.021217037,
0.010507869,
-0.015218292,
0.0056330496,
-0.012467191,
-0.024719661,
-0.018479355,
0.009367168,
-0.020801017,
-0.027752584,
-0.011433849,
0.027967304,
0.020036077,
0.013084511,
0.008790107,
0.0075084963,
0.00071168,
-0.020089757,
-0.010467608,
-0.021123098,
-0.0026303222,
0.019029576,
-0.028020984,
0.016332153,
-0.009789898,
0.012621521,
0.019821357,
0.001507235,
0.0003367584,
-0.005089539,
0.0061966903,
0.01178277,
0.02498806,
0.0044655087,
0.013795772,
-0.00046215163,
-0.01231957,
0.016600555,
-0.018371996,
0.018640395,
0.019418756,
0.02419628,
-0.0044957036,
-0.009836868,
-0.0013520662,
-0.015594053,
-0.020572877,
0.00596855,
0.023028739,
0.015553793,
0.0020834568,
-0.003509333,
0.03454311,
-0.009716088,
-0.0013570987,
-0.040098995,
-0.019552957,
0.019042997,
-0.01266178,
-0.008045297,
-0.64845496,
-0.014372832,
-0.018559875,
-0.00612288,
0.009004828,
0.022746919,
0.026732663,
0.00614972,
-0.008870628,
0.007488366,
0.0008731395,
0.007870836,
0.016385833,
-0.008058717,
-0.01202433,
-0.025578542,
-0.004790944,
0.0052639996,
0.031322308,
-0.01195723,
-0.0114472695,
-0.0016364026,
0.019512696,
0.022948219,
0.032637466,
0.018479355,
0.0012866436,
-0.012816111,
-0.005213674,
0.009206127,
0.020505777,
0.029094584,
0.017741255,
0.014292312,
0.041145753,
-0.0114137195,
-0.007011956,
0.010165659,
-0.0016699526,
0.028208863,
-0.016426094,
0.027484182,
0.02539066,
-0.009528208,
-0.008320407,
0.015003572,
0.019901877,
-0.008749847,
0.0039018684,
0.013862872,
-0.009394008,
-0.02411576,
-0.016667655,
0.016707914,
0.000055829343,
-0.0071931263,
0.006706651,
0.0053814244,
-0.005002309,
0.028853023,
0.015124353,
0.020666817,
-0.0065120603,
-0.009018248,
-0.010568259,
0.03389895,
-0.011440559,
0.015191453,
-0.0035160428,
-0.003465718,
0.007488366,
0.027188942,
0.018278055,
-0.0074615264,
0.0147351725,
-0.00048186228,
0.0039421283,
0.015365913,
-0.02526988,
0.01135333,
0.00033780685,
0.027256044,
-0.0026840023,
0.015929554,
0.027095003,
0.010990989,
-0.031590708,
0.011326489,
-0.0013830999,
-0.010736009,
0.0005489623,
-0.0016229826,
-0.022652978,
-0.015674572,
-0.0033835203,
0.031322308,
0.019472437,
0.0008253307,
0.013916552,
-0.029685065,
-0.018345155,
0.0075487564,
-0.015365913,
0.0001915497,
0.0010199208,
0.015352493,
-0.024880702,
-0.017902294,
0.04468864,
-0.03575091,
0.017070254,
0.01163515,
0.010319988,
-0.008776687,
-0.020774178,
-0.038059153,
0.00571357,
0.012749011,
0.012795981,
-0.033818427,
0.015459853,
-0.020707076,
0.0053109694,
-0.007958067,
0.0076695364,
0.0070320857,
-0.027121842,
-0.009836868,
0.0074749463,
-0.03301323,
-0.01134662,
0.024665982,
0.029711904,
-0.003767668,
0.0097362185,
0.0077836066,
0.027833104,
0.021230457,
-0.0006961631,
-0.016801855,
-0.014869372,
0.0143862525,
-0.013567631,
0.019150356,
0.013500531,
-0.021123098,
0.022746919,
0.017821776,
0.0015709801,
-0.019499276,
-0.008347247,
-0.03626087,
-0.021109678,
-0.010118688,
-0.0027511022,
0.0019391916,
-0.026356902,
-0.0248136,
-0.012326281,
-0.010776269,
0.007219966,
-0.004666809,
-0.02422312,
0.011474109,
-0.00075194,
-0.02241142,
-0.0043346635,
0.01252758,
-0.010850079,
-0.025417501,
0.018841695,
0.0046366137,
0.008031877,
0.01177606,
-0.016748173,
0.006106105,
-0.012869791,
-0.02446468,
-0.027806263,
0.0037743782,
0.0077970265,
-0.017191034,
-0.0012119948,
0.013681701,
0.023525279,
0.020680238,
0.010561549,
0.01117216,
-0.0028702049,
0.022183279,
0.0014879437,
-0.0043078237,
-0.021592798,
0.021404918,
-0.010454189,
-0.017392335,
0.010876919,
-0.0026269672,
0.036502432,
0.03320111,
0.015916133,
-0.013165031,
0.027564703,
-0.0065858704,
0.0064885756,
0.008555257,
0.007394426,
0.004764104,
0.03456995,
0.01237996,
0.009555048,
-0.01138017,
-0.036931872,
-0.0244781,
-0.031456508,
0.019526117,
-0.019418756,
-0.014627812,
-0.008078847,
0.020626558,
-0.000432376,
0.0120444605,
0.017083675,
-0.008313697,
-0.03741499,
0.0075823064,
0.016439514,
0.030168185,
-0.021619638,
-0.0220625,
-0.027068162,
0.0034556529,
0.020975478,
-0.010071718,
-0.0055625946,
0.013258971,
0.016358994,
0.01252087,
0.018023076,
0.030866025,
0.02361922,
0.0067502656,
0.017714415,
-0.039776914,
0.01252758,
0.00299434,
0.027108423,
0.02412918,
-0.008588807,
0.02250536,
0.02419628,
0.01269533,
-0.00026756147,
-0.016895793,
-0.03577775,
0.0006995181,
0.0139299715,
-0.002254562,
0.015016993,
0.021123098,
0.030517105,
0.03432839,
0.018586716,
-0.007609146,
-0.0024374095,
0.018828277,
0.007890967,
-0.004931854,
0.013292521,
-0.016895793,
-0.0024977997,
0.019271135,
-0.008850497,
-0.02343134,
0.010722589,
0.023015318,
0.022478519,
-0.008803528,
0.0246123,
0.013158321,
0.0063711503,
-0.028074663,
0.027014483,
0.014037332,
0.003529463,
-0.001742924,
-0.016962893,
-0.027269462,
-0.013205291,
0.0238071,
-0.008152657,
-0.0026202572,
0.004814429,
-0.013433431,
-0.019982398,
-0.006951566,
0.020774178,
-0.0044453787,
0.042756155,
-0.013138191,
0.017539954,
0.013366331,
-0.020626558,
-0.013352911,
0.03400631,
0.019485855,
0.016305314,
-0.013030831,
0.020291056,
0.0060021,
0.0054787197,
0.0022226893,
-0.003529463,
-0.00299434,
-0.0055592395,
0.031134427,
-0.014963312,
0.00058880297,
0.046191677,
-0.021686738,
-0.0066194204,
-0.025846941,
-0.01178948,
-0.03623403,
0.039159592,
0.011292939,
0.0017848614,
0.0041300086,
0.0009712733,
-0.0040763286,
-0.018036496,
-0.031268626,
0.029416665,
0.009112188,
-0.0010836659,
-0.0027091647,
0.023230039,
-0.0065657403,
0.009863708,
0.02304216,
-0.0055760145,
-0.028718824,
-0.0044051185,
-0.010521289,
0.0065724505,
-0.0007951357,
0.03373791,
0.052499086,
0.021874618,
-0.015929554,
0.01249403,
0.010199209,
0.028960384,
0.0044051185,
-0.0061262352,
0.020707076,
-0.010266309,
0.013480402,
-0.010158949,
-0.02438416,
-0.008702877,
0.007991617,
0.014050752,
0.004542674,
0.019472437,
0.029819265,
0.0019073191,
-0.005126444,
-0.0015323976,
-0.031027066,
0.022116179,
-0.0077836066,
0.007146156,
-0.015822193,
0.037629712,
-0.00576725,
-0.020036077,
-0.01184987,
0.020103177,
0.0052874843,
-0.009447688,
-0.0053612944,
-0.025068581,
-0.009018248,
-0.027001062,
-0.018278055,
0.025350401,
-0.016587134,
-0.017862035,
-0.01124597,
-0.01117887,
-0.0030664725,
-0.008441187,
0.011366749,
-0.013077801,
-0.008186207,
-0.014211792,
0.037898112,
0.027618384,
-0.004834559,
0.018626975,
-0.0019962266,
-0.008810237,
0.025162522,
-0.02490754,
-0.01163515,
-0.005938355,
-0.014587552,
-0.00023736645,
0.008052006,
-0.02404866,
-0.0077366363,
0.004928499,
-0.006830786,
0.018143855,
-0.02416944,
0.020022657,
-0.03897171,
0.019713996,
-0.006958276,
0.011722379,
0.027725743,
-0.00585448,
0.00016418545,
0.0013453561,
-0.047184758,
0.012722171,
-0.01223905,
0.0044051185,
0.0012103172,
-0.010709169,
-0.0038012182,
-0.002278047,
-0.008400927,
0.006032295,
-0.0063812155,
-0.009219548,
0.0006940662,
0.027591543,
0.016694494,
-0.0052069644,
0.02242484,
0.0070522157,
0.00555253,
0.0013537436,
0.009568468,
0.025873782,
0.010702459,
-0.030087665,
0.02214302,
0.001742924,
-0.03363055,
-0.016976314,
0.016412674,
0.004837914,
0.016345574,
-0.022371158,
-0.025229622,
-0.027940463,
-0.008622358,
-0.007897677,
0.0077768965,
-0.009098767,
0.003734118,
-0.020116597,
0.013836032,
-0.00028182025,
-0.008159366,
0.04710424,
-0.032234866,
-0.0013344524,
-0.0062537254,
-0.02242484,
-0.014453352,
-0.0040226486,
0.001204446,
0.0003627597,
0.010937309,
-0.036931872,
-0.03730763,
-0.030087665,
-0.000019343688,
0.0027410374,
0.040421072,
0.038944874,
0.0031134426,
-0.010172369,
0.030892866,
-0.010360248,
0.017204454,
-0.020478938,
0.010729299,
-0.015902713,
0.03690503,
0.018090175,
-0.01238667,
0.022532199,
-0.009179288,
0.0054418147,
0.010205919,
-0.013876292,
-0.008166077,
-0.0024206345,
-0.03658295,
0.004653389,
0.02369974,
-0.01199749,
-0.004858044,
-0.041843597,
-0.034516267,
0.05818917,
-0.015365913,
0.013849451,
-0.018855115,
-0.0070522157,
-0.025659062,
0.02399498,
0.01202433,
0.009749638,
0.0122524705,
-0.025846941,
-0.016010074,
0.0040192935,
0.017164195,
-0.009031667,
0.00292724,
-0.0038951582,
0.018251216,
-0.028853023,
0.0055391095,
-0.007079056,
0.007320616,
0.0027511022,
-0.010501158,
-0.007575596,
-0.004596354,
-0.017821776,
-0.015808774,
0.015285393,
0.021324398,
-0.02357896,
0.020653397,
-0.039293792,
0.006132945,
-0.0064785103,
-0.014520452,
0.030007144,
-0.0067905257,
0.026611883,
0.02325688,
-0.016895793,
-0.0043145334,
0.02214302,
0.020344738,
0.013862872,
0.014023912,
-0.008682747,
-0.019713996,
-0.009018248,
-0.0075823064,
0.038193353,
-0.0041602035,
-0.014158112,
0.048151,
-0.008421057,
0.01131978,
-0.01121242,
-0.01230615,
-0.02392788,
0.0026638722,
-0.017888876,
-0.007662826,
0.017660735,
-0.0037643132,
-0.014990153,
0.021082837,
0.01245377,
0.019646896,
0.013044251,
-0.009347037,
-0.0005024117,
0.026987642,
-0.026987642,
-0.0037106331,
0.016546873,
0.029953465,
0.0027326497,
0.001144056,
0.015043832,
0.011688829,
0.013507241,
0.0021606218,
-0.012836241,
0.037334472,
0.0043615038,
-0.0040360685,
0.019204035,
-0.009897258,
0.018559875,
-0.004616484,
-0.005911515,
-0.047184758,
-0.016291894,
0.009259808,
0.017580215,
-0.0055827247,
-0.026665563,
-0.0092799375,
-0.017284974,
-0.0017278264,
-0.026397161,
-0.0062201754,
0.008025167,
-0.019767677,
-0.018640395,
0.0064147655,
-0.02438416,
0.016520035,
0.00014374091,
0.0032426103,
0.008119107,
0.0061631403,
-0.009333618,
0.03344267,
-0.0063644405,
-0.0020280993,
-0.02391446,
0.019472437,
-0.039079074,
-0.0013235486,
-0.0068341405,
0.0053076143,
-0.028504103,
-0.01209143,
0.0012581261,
0.0077768965,
-0.0037206982,
-0.001816734,
0.0097362185,
0.002234432,
0.020868117,
-0.002856785,
-0.007488366,
0.008682747,
-0.015714834,
-0.0052103195,
0.027886784,
-0.03432839,
0.0020817793,
0.00016858889,
0.0029725325,
0.012574551,
-0.00292724,
-0.0075487564,
-0.040689476,
0.0014711687,
-0.021498857,
-0.014265472,
-0.020062916,
-0.009494658,
-0.013131481,
0.005935,
-0.007944646,
-0.012259181,
-0.019016156,
0.010957439,
-0.017097095,
-0.004542674,
-0.021351239,
0.0077701863,
0.008394217,
0.008005037,
-0.025202781,
-0.0008370732,
-0.0061363,
0.028289383,
0.020411838,
-0.012889921,
-0.0077433465,
0.003636823,
-0.056900848,
-0.041736234,
-0.009038378,
0.026625302,
-0.006186625,
-0.012400091,
0.0050090193,
0.0043916986,
-0.017204454,
-0.010769559,
-0.013614601,
-0.012507451,
0.014493613,
-0.010111978,
0.013359621,
0.00040218097,
-0.041226275,
-0.012500741,
0.025699321,
-0.019324817,
-0.00584777,
0.019942136,
0.0058679,
0.007126026,
0.0068609808,
0.021042578,
0.0051398645,
-0.0075957263,
0.019459017,
-0.02290796,
0.0025330272,
0.027886784,
-0.014171531,
0.0015516888,
0.002590062,
-0.0008458801,
0.0074078464,
-0.01113861,
-0.01206459,
-0.016305314,
0.013151611,
-0.022330899,
-0.01103125,
-0.0039152885,
-0.023377659,
0.030463425,
0.009870418,
-0.018170696,
-0.027511023,
0.004968759,
0.0045158337,
0.021136519,
0.0063979905,
-0.005938355,
-0.021592798,
-0.009957648,
0.021310978,
-0.014829112,
0.008286857,
-0.009602018,
0.020546038,
-0.0067737508,
0.022022238,
0.006280565,
0.0059148697,
-0.002432377,
0.0008295244,
0.00038079283,
0.019901877,
-0.026424002,
0.015057253,
-0.013956811,
-0.013889711,
0.0042340136,
-0.025095422,
0.00051918667,
-0.014668073,
-0.020841278,
-0.0041098786,
0.027215783,
0.1866992,
0.0009771446,
0.011373459,
0.040313713,
0.008441187,
0.0114137195,
0.0003654856,
0.00026231928,
-0.013621312,
0.016412674,
-0.005824285,
0.0054887845,
-0.022169858,
-0.004770814,
0.014507032,
-0.017727835,
-0.028369904,
-0.019539537,
0.0041534933,
-0.007394426,
0.011185579,
0.00011113447,
-0.001211156,
-0.008642487,
0.030168185,
-0.01193039,
-0.008816947,
0.008374087,
0.03376475,
0.0031956402,
-0.011219129,
0.010782979,
-0.000109142435,
0.009870418,
-0.00008869789,
-0.016600555,
0.0053680046,
0.0005376392,
0.0027443923,
-0.007058926,
0.01270204,
-0.006938146,
-0.021981979,
-0.009716088,
-0.017137354,
0.041145753,
-0.01186329,
-0.004613129,
-0.01263494,
-0.03384527,
-0.025645642,
0.013010701,
0.019284556,
0.014882793,
-0.0032107376,
-0.015607473,
0.022236958,
-0.0008697845,
0.014788852,
-0.01187671,
-0.022733498,
-0.0234716,
-0.0063543753,
0.031483345,
-0.018371996,
0.0065019955,
-0.02310926,
-0.0025011546,
-0.018157275,
0.011440559,
-0.007448106,
-0.03569723,
0.0064449604,
-0.00037995406,
-0.03475783,
-0.008736427,
0.022867698,
0.015567213,
0.012863081,
0.008280147,
-0.0052707093,
-0.025216201,
-0.017097095,
0.003532818,
-0.021109678,
-0.056578767,
-0.0044420236,
0.009320198,
-0.004707069,
-0.0024206345,
-0.013305942,
-0.024504941,
-0.033496346,
-0.016305314,
0.016358994,
-0.013520662,
-0.0040394235,
0.01156134,
0.0010148884,
0.013460271,
0.0014074236,
0.06489918,
0.006119525,
-0.0080922665,
0.0018888665,
0.018680656,
-0.0072468063,
0.022652978,
0.004988889,
-0.01159489,
-0.007662826,
-0.016520035,
-0.0069784056,
-0.025310142,
-0.014345992,
0.015580633,
0.032395907,
-0.027148683,
0.0031201525,
-0.005072764,
-0.0128094,
-0.01186329,
-0.002244497,
0.028799344,
0.0002755296,
-0.022894539,
-0.015996654,
0.026075082,
-0.009789898,
-0.020009236,
0.002944015,
-0.019297976,
0.009937518,
-0.014990153,
0.029067744,
0.021203618,
-0.01182303,
-0.00087397825,
0.007072346,
-0.004834559,
0.01142043,
0.0016657589,
-0.0056364047,
0.02449152,
0.016855534,
-0.015969813,
0.00589474,
0.0126013905,
-0.00602894,
0.003660308,
-0.010970859,
-0.013688412,
0.026920542,
-0.020841278,
0.015070672,
-0.028477265,
-0.0033063553,
-0.032288548,
0.005159994,
-0.004348084,
-0.013077801,
0.0039119334,
0.014574132,
-0.009360458,
-0.017097095,
-0.0018150565,
-0.17016575,
0.02490754,
0.027698902,
-0.007011956,
0.014158112,
-0.00016659686,
0.03577775,
0.020277636,
-0.018774595,
-0.004344729,
0.028853023,
-0.0013570987,
0.0009394008,
-0.013594471,
0.0010299858,
0.024867281,
-0.002227722,
-0.01217866,
0.015392753,
0.0011339909,
0.028638303,
-0.015406173,
0.013218711,
-0.028182024,
-0.002382052,
-0.0005934161,
0.0039488385,
-0.00084504136,
0.0054518795,
-0.026289802,
-0.03666347,
0.021807518,
0.03926695,
-0.011366749,
-0.0074548163,
0.018358575,
0.014399672,
-0.009185998,
-0.01131978,
0.013144901,
0.015379333,
0.0063241804,
-0.005830995,
-0.02462572,
-0.026799763,
-0.0053009046,
-0.010507869,
-0.0021606218,
0.024733081,
-0.027806263,
0.0076024365,
-0.018533036,
0.014681492,
0.023162939,
0.01166199,
0.014949893,
-0.017526535,
0.013413302,
0.0025850297,
-0.015419593,
-0.0072803563,
0.0046198387,
0.0246123,
0.007313906,
0.0037274081,
-0.03475783,
0.0032912577,
-0.0077097965,
-0.008783397,
0.020760758,
-0.02392788,
-0.03459679,
0.002261272,
-0.02429022,
0.03583143,
0.0073340363,
-0.009709378,
0.01237996,
-0.015580633,
0.018452516,
-0.021726998,
0.037361313,
-0.0065590306,
-0.02335082,
-0.01182303,
0.03175175,
-0.0039421283,
0.009655698,
0.015956393,
0.016385833,
0.008850497,
-0.018492775,
0.0007875869,
-0.022304058,
0.001826799,
-0.000386035,
-0.001726149,
-0.028316224,
-0.0053981994,
-0.020223957,
0.026692402,
-0.03475783,
0.0001932272,
0.02547118,
0.01223905,
0.008977988,
-0.0017152452,
0.014748592,
0.03446259,
-0.015513533,
0.0044118287,
-0.001773119,
-0.0015625926,
0.03301323,
0.0040998133,
0.02596772,
0.013768932,
-0.028074663,
-0.00006710005,
-0.026947383,
0.04458128,
0.0053378097,
0.0043011135,
0.014963312,
0.009139027,
-0.024947802,
-0.1218537,
-0.029282464,
0.0038481883,
0.028987225,
0.0245452,
0.038193353,
0.0028282674,
0.028074663,
-0.00614972,
0.00609604,
-0.0018452515,
0.0011750897,
0.010876919,
-0.015526953,
0.02391446,
-0.0055659497,
0.0016288538,
0.008011747,
-0.018090175,
0.031859107,
-0.0051130243,
-0.015661154,
0.00629734,
-0.004847979,
0.0060222303,
0.019230876,
-0.016667655,
0.031214947,
0.013715251,
0.0053747143,
0.017204454,
0.014023912,
0.0054418147,
-0.003024535,
-0.028128343,
-0.014037332,
-0.00097211206,
-0.02310926,
0.057867087,
-0.0039454834,
0.017365495,
0.014466772,
0.02489412,
-0.015446433,
-0.014359412,
-0.008481447,
-0.029443504,
0.018989315,
-0.020358156,
-0.038085993,
-0.015701413,
-0.004864754,
-0.004488994,
0.030490266,
0.02402182,
-0.015137773,
0.028691985,
0.007870836,
-0.02412918,
-0.017110514,
0.01258797,
-0.0006202561,
-0.021055998,
0.018224375,
0.017191034,
-0.023444759,
-0.02403524,
-0.01231957,
-0.0032509977,
-0.019190617,
0.00288027,
0.012547711,
0.0031419601,
0.009192708,
-0.03631455,
-0.006045715,
-0.033093747,
-0.0037643132,
0.01223234,
0.0003518559,
-0.011514369,
-0.02348502,
0.010923889,
-0.028182024,
-0.01164857,
0.016506614,
0.0066965856,
-0.012836241,
0.009139027,
-0.009414138,
-0.028101504,
0.010366959,
-0.00089578575,
-0.015446433,
-0.0029121425,
0.015620893,
-0.007266936,
-0.0019006091,
0.003448943,
0.015781933,
-0.00549885,
-0.03956219,
-0.05979957,
-0.0016925989,
0.021404918,
-0.01171567,
0.0018754465,
0.0038414781,
0.02374,
0.016144274,
0.010675619,
-0.021861197,
-0.055183087,
-0.0141044315,
-0.011125189,
0.0027410374,
-0.031402826,
0.00065883866,
0.017284974,
-0.0032493202,
0.008501577,
0.001547495,
0.013742091,
0.018506195,
-0.0053176796,
0.0145607125,
0.0068039456,
-0.00289369,
-0.008709587,
-0.01248732,
-0.011655279,
-0.0016246601,
-0.010192499,
-0.037951794,
-0.015674572,
0.01255442,
-0.02388762,
0.01149424,
-0.000035175108,
0.027591543,
0.015446433,
0.0052002543,
-0.015929554,
-0.022814019,
-0.023176359,
-0.032530107,
0.0034271353,
0.007991617,
-0.017929135,
0.027430503,
-0.019499276,
-0.0013822612,
0.0026286447,
0.01110506,
-0.005830995,
-0.031161265,
-0.019767677,
0.008998117,
0.0010132109,
0.007857417,
-0.0013478724,
-0.015513533,
0.0142788915,
-0.007307196,
0.009253098,
-0.010326698,
0.005830995,
-0.0041971086,
-0.00026462585,
-0.012896631,
0.020586297,
-0.0032828702,
-0.021284137,
-0.019901877,
-0.006293985,
-0.01192368,
0.0118029,
-0.0019878391,
0.0077165063,
0.017217875,
0.000031217252,
-0.007079056,
0.0015634313,
-0.0019593216,
-0.03698555,
0.017338654,
0.03618035,
0.0019895167,
0.016197953,
0.018318316,
0.016788434,
-0.007850707,
-0.021109678,
0.0056665996,
-0.0040159384,
0.00018043624,
0.00055357546,
0.031375986,
0.016385833,
-0.019418756,
0.02553828,
0.018559875,
0.022397999,
0.033523187,
-0.0023703096,
-0.032127507,
0.0054921396,
0.0012405122,
-0.008937728,
-0.044071317,
-0.027282882,
0.0044822837,
0.009810029,
0.00583435,
-0.0041635586,
-0.0007255194,
0.010306569,
0.03387211,
-0.027591543,
-0.007897677,
-0.015043832,
0.027645223,
-0.010628649,
0.012675201,
0.003559658,
0.008944438,
-0.009212838,
0.024853861,
0.037763912,
-0.013560921,
0.0234716,
-0.014211792,
0.017191034,
0.0012723848,
-0.03387211,
-0.02459888,
0.0050291494,
-0.03607299,
0.007401136,
0.013701832,
-0.008615647,
0.08980671,
0.0061664954,
-0.00614972,
-0.005951775,
0.00038037344,
0.03940115,
-0.00289369,
0.017781515,
-0.018707495,
-0.02335082,
0.0025481246,
-0.0081258165,
0.004468864,
-0.040662635,
-0.03304007,
0.01211156,
0.0028853025,
0.0066060005,
-0.0024340546,
-0.020264218,
0.000084766245,
-0.0064583803,
-0.0010551484,
0.008152657,
-0.01150095,
-0.024504941,
0.03618035,
-0.004931854,
-0.003576433,
-0.029685065,
-0.0026940673,
0.02540408,
-0.037790753,
-0.018023076,
0.00294737,
-0.004982179,
0.0025246397,
-0.017110514,
-0.0040293583,
-0.015553793,
-0.0007095831,
0.027390243,
-0.02298848,
-0.015298813,
-0.018895376,
-0.008293567,
-0.020277636,
0.0059148697,
-0.015996654
] |
Loss of Omi/HtrA2 function leads to nerve cell loss in mouse models and has been linked to neurodegeneration in Parkinson's and Huntington's disease. Omi/HtrA2 is a serine protease released as a pro-apoptotic factor from the mitochondrial intermembrane space into the cytosol. Under physiological conditions, Omi/HtrA2 is thought to be involved in protection against cellular stress, but the cytological and molecular mechanisms are not clear. Omi/HtrA2 deficiency caused an accumulation of reactive oxygen species and reduced mitochondrial membrane potential. In Omi/HtrA2 knockout mouse embry | [
-0.015188137,
-0.011404543,
-0.0014146473,
-0.027137034,
-0.031344015,
0.033118203,
-0.019838665,
0.02120963,
-0.0072714887,
0.010732502,
0.02026877,
-0.00055821444,
0.010927394,
-0.017056413,
-0.023534892,
-0.009247291,
0.043682694,
0.004438834,
0.015967704,
0.009301053,
-0.019516084,
0.0073790154,
0.0008362716,
-0.013198894,
0.028897783,
0.0011626317,
-0.0002171534,
-0.04634398,
-0.015994586,
-0.030671973,
0.0010660258,
0.00059097644,
-0.007896487,
-0.009697558,
0.008743259,
-0.007916648,
0.013051045,
0.007103478,
0.01183465,
-0.006370953,
0.0044220327,
0.020658555,
-0.0136424415,
0.006730495,
-0.003291323,
0.008393798,
-0.0038877598,
-0.0047882954,
-0.018749956,
0.017096736,
0.0075268643,
0.012688143,
-0.011922016,
-0.009596752,
-0.007311811,
0.01716394,
-0.001606179,
0.018481141,
0.006629689,
-0.014059108,
0.0025957602,
-0.0077553582,
-0.027741872,
0.01638437,
0.008615571,
0.022567153,
-0.011841371,
0.011545672,
-0.0085282065,
0.012741906,
0.046263333,
0.010268793,
-0.025537575,
-0.0078158425,
0.012190832,
-0.013272819,
-0.038924642,
-0.0050671925,
0.010342718,
-0.00031249927,
0.026666606,
-0.022782205,
-0.008541647,
0.019677375,
0.023360161,
-0.018051034,
-0.014435451,
0.024610158,
0.017042972,
0.006256706,
0.023212312,
0.009966374,
0.0060080504,
0.010799706,
-0.024005322,
0.014435451,
-0.025161233,
0.030430038,
-0.02526876,
-0.0020295652,
-0.016612865,
-0.011404543,
-0.021962315,
-0.01684136,
-0.015779534,
-0.006948909,
0.008521486,
0.0018917967,
0.006874984,
-0.021263393,
-0.0055174604,
0.010073901,
-0.022083282,
-0.042741835,
0.0010425043,
0.0048386985,
0.046747204,
0.015013406,
-0.020201566,
-0.0012768788,
0.012600778,
0.027311765,
0.009489225,
-0.024368223,
0.006239905,
0.014005344,
-0.00053343293,
-0.018172001,
-0.0028326546,
-0.012305079,
0.019878987,
0.017553722,
0.041612808,
0.004334667,
-0.024005322,
0.03873647,
-0.030887026,
-0.00987901,
-0.007090037,
-0.042876244,
0.026989184,
0.008434121,
-0.0021354118,
-0.011653199,
-0.008944872,
0.024502631,
0.026491875,
0.0013398826,
-0.0037365505,
0.016075231,
0.014986524,
-0.013723087,
0.0010307436,
-0.04588699,
0.022849409,
0.019153181,
0.008870947,
0.020618232,
-0.03564508,
-0.026478434,
-0.012788949,
-0.022486508,
0.008588689,
0.020551028,
0.02463704,
0.020537587,
-0.008958313,
0.008387078,
0.02120963,
-0.016008027,
-0.0068951454,
0.025833273,
-0.010383041,
0.03354831,
-0.018373614,
0.01752684,
0.008494604,
0.017069854,
-0.021021457,
-0.021854788,
-0.009395139,
0.008407239,
0.02172038,
-0.0011491909,
-0.004183458,
0.01637093,
0.023790268,
-0.0012735185,
0.01880372,
-0.01944888,
-0.004099453,
-0.001980842,
0.00034967158,
0.0053057675,
-0.63483727,
-0.028360149,
-0.0044657155,
0.007231166,
0.016653188,
0.020967694,
0.01411287,
-0.010107503,
-0.011713683,
0.005231843,
-0.0076276707,
0.020645114,
-0.00033455063,
-0.043655813,
-0.003062829,
-0.020470383,
-0.012204273,
-0.022459626,
0.015981145,
-0.007600789,
-0.029274127,
-0.0072177253,
-0.029973049,
0.0031921968,
0.0011256695,
0.023682741,
0.016868241,
-0.017809099,
-0.019341353,
0.05645148,
-0.0034811748,
0.019825224,
-0.026048327,
-0.0005363731,
0.04913967,
-0.007916648,
-0.0035248573,
0.0444085,
0.008561809,
0.030268747,
-0.011639758,
0.005060472,
0.021787584,
-0.0008761741,
0.00080476963,
0.0036727067,
0.010759383,
-0.014327924,
0.019112859,
-0.006528883,
0.00567875,
0.024704244,
-0.005268805,
0.013723087,
-0.010631696,
-0.00729165,
0.034059063,
-0.011209652,
0.013185454,
-0.0026596042,
0.00017767095,
0.033467665,
-0.007896487,
-0.034435403,
-0.020295652,
0.0021018097,
-0.019045655,
-0.008245949,
0.004670688,
-0.0072714887,
0.004586683,
0.01959673,
-0.01637093,
0.031075196,
0.0110282,
0.026236499,
-0.0063440716,
0.0065860064,
-0.0061558997,
0.035940778,
0.0058434005,
0.0056619495,
-0.006592727,
-0.004657247,
0.034919273,
0.0053460896,
-0.02577951,
0.03489239,
0.00006599657,
-0.006935468,
0.026075209,
-0.0019102779,
-0.004260743,
-0.015806414,
-0.019865546,
0.01975802,
-0.0028645766,
0.013232497,
0.0014238878,
-0.016451575,
-0.0030611488,
-0.0047614137,
0.023239193,
-0.008219067,
0.008904549,
0.011370941,
-0.03876335,
0.0011811128,
0.045080543,
0.0072244457,
-0.015766094,
-0.008736539,
-0.009677397,
-0.024529513,
-0.0018212324,
-0.00858197,
0.022970377,
0.00971772,
-0.009442182,
-0.034462284,
0.00063171895,
-0.0075604664,
0.010907233,
-0.0010357839,
0.009603472,
0.015403191,
0.020040276,
-0.02561822,
-0.00907928,
-0.0034139706,
-0.0023639058,
-0.018051034,
0.00470429,
-0.024435427,
0.02220425,
-0.004926064,
0.016196199,
0.0028612164,
0.008151863,
-0.019314472,
-0.014838675,
-0.01312497,
0.0106182555,
-0.0015322545,
-0.005262085,
-0.028521439,
0.014865557,
-0.007822563,
0.018225765,
-0.004801736,
-0.008629012,
0.00005008809,
-0.010557772,
0.0145833,
0.020981135,
-0.022110164,
-0.010100783,
-0.0024882336,
0.0069959518,
-0.01684136,
0.0024411906,
0.028817138,
0.00031858965,
0.018051034,
-0.024085965,
-0.0058568413,
0.010322557,
0.013098088,
-0.0046102046,
-0.008501325,
-0.024905857,
0.00046790886,
-0.028870901,
-0.0031081918,
0.003551739,
0.021330595,
0.007715036,
0.003338366,
-0.0015960984,
0.0009257371,
-0.0005078113,
-0.03244616,
0.00040343488,
-0.007553746,
0.021532208,
-0.005265445,
0.027378969,
0.006115577,
0.010638417,
0.031370897,
-0.0022933416,
0.020147802,
-0.004583323,
0.017244583,
-0.0028259344,
-0.028628966,
0.014905879,
0.006518802,
0.0019186784,
0.03674723,
0.023588656,
-0.0347311,
-0.007473101,
-0.03309132,
0.0129704,
0.0035853412,
0.002575599,
-0.020779522,
0.009919332,
-0.013198894,
-0.015994586,
-0.007197564,
-0.0051612784,
-0.025349405,
-0.00024109488,
0.008004013,
-0.0012298359,
-0.0051175957,
-0.0025924,
-0.044650435,
0.018104797,
-0.013346744,
0.003615583,
-0.0106989,
0.026774133,
0.009180087,
0.015860178,
0.030510683,
0.010329277,
-0.018427378,
0.0037735128,
-0.007553746,
-0.003958324,
0.0030241865,
0.02512091,
0.020161243,
-0.0009778204,
0.00470429,
0.042499904,
-0.007553746,
-0.01815856,
0.0026478434,
0.0016339008,
-0.0053460896,
-0.007305091,
-0.022647798,
0.041397754,
0.0019842023,
-0.008071218,
0.027204238,
-0.030026812,
0.00485886,
-0.021680057,
-0.0011449907,
-0.003195557,
-0.01102148,
0.001491092,
-0.020698877,
0.046774086,
0.012345402,
0.03155907,
-0.021975756,
0.016142435,
-0.019637052,
0.0014784912,
-0.00029884843,
0.0034778146,
0.015591362,
0.0073454133,
-0.016989209,
-0.013588678,
-0.0031669955,
-0.0028679369,
-0.020241888,
0.03166659,
0.021465003,
0.020981135,
0.018736515,
0.019475762,
0.007473101,
-0.033628955,
-0.047983762,
0.037499912,
0.01346771,
-0.019489203,
-0.005057112,
-0.012896475,
-0.016142435,
-0.020873608,
0.0145295365,
0.012715024,
0.0072849295,
0.01716394,
0.02219081,
-0.022970377,
-0.01263438,
0.029516062,
-0.028628966,
0.03677411,
0.008561809,
0.005900524,
0.011801048,
-0.020551028,
-0.00045656817,
0.03293003,
0.032956913,
-0.0040288884,
0.005934126,
-0.020766081,
-0.017634368,
0.0077284765,
-0.032876268,
-0.0035248573,
-0.0059240456,
-0.0133265825,
0.0033686077,
0.0018262727,
0.0136424415,
0.0049294243,
-0.015053729,
-0.014502655,
-0.020335974,
-0.010947555,
-0.016653188,
0.029919285,
0.028118216,
-0.010806426,
0.0036525454,
-0.001409607,
0.030940788,
0.0077284765,
-0.033790246,
0.010167987,
-0.0053931326,
0.010342718,
-0.008461002,
0.002187495,
0.019018773,
0.019314472,
0.008004013,
0.016411252,
-0.031854764,
0.005312488,
0.008071218,
-0.0013037605,
-0.014018785,
0.0098588485,
0.032231107,
0.03129025,
0.012251316,
0.009973095,
0.027338646,
0.025241878,
-0.015376309,
0.0011399504,
-0.01150535,
0.0026545639,
0.0009652196,
-0.012432767,
-0.03551067,
-0.009590032,
0.022661237,
0.007258048,
0.018091356,
0.02740585,
0.013575237,
-0.010725781,
0.004831978,
-0.010477127,
-0.0013566837,
-0.003776873,
0.016451575,
0.0106989,
-0.02059135,
0.008965033,
-0.0013667643,
-0.024704244,
-0.0135953985,
0.015094051,
-0.007211005,
-0.0155107165,
-0.0030040252,
0.0020329254,
-0.010342718,
0.009166646,
-0.030752618,
0.012244595,
-0.022338659,
0.017930066,
-0.023642419,
-0.019220386,
-0.006065174,
-0.022715,
-0.023212312,
0.03258057,
-0.012210993,
-0.02787628,
0.026276821,
0.0059509273,
0.028279504,
0.0029401814,
-0.038790233,
0.0049193436,
0.016169317,
-0.006031572,
-0.0012735185,
-0.0191263,
-0.013749968,
0.010315836,
-0.015322546,
-0.009348096,
-0.0159005,
0.00020371257,
0.021303713,
0.012694864,
-0.01896501,
-0.0014314483,
0.019569848,
-0.0065524043,
-0.0039482433,
0.021706939,
0.0191263,
-0.015631685,
-0.00092489703,
0.015551039,
-0.040430013,
-0.018091356,
-0.026706928,
-0.01556448,
-0.027607463,
-0.00034127105,
-0.0037063085,
0.02252683,
-0.011807769,
0.014637063,
0.013481151,
0.021948874,
-0.01736555,
0.00972444,
0.007963691,
0.014556418,
0.030860145,
-0.0005111715,
-0.002839375,
0.009247291,
-0.022594035,
0.019811783,
0.00015372949,
0.016236521,
0.0070429943,
0.011801048,
-0.013387066,
-0.030295629,
0.0061323782,
0.0005855161,
0.022244573,
-0.008575249,
-0.01637093,
-0.021693498,
-0.020551028,
-0.029462298,
0.00091817667,
0.01654566,
0.0011752325,
-0.00810482,
-0.0122177135,
-0.024704244,
0.003225799,
0.011733844,
-0.03551067,
-0.018790279,
0.010779545,
0.00599461,
0.0015977785,
0.010591374,
-0.012365563,
-0.045698818,
-0.018521463,
-0.023158548,
-0.03731174,
-0.0044825166,
-0.0127083035,
0.011801048,
0.031908527,
0.015940823,
-0.00027196677,
0.014650504,
0.0127083035,
0.004274184,
0.025819832,
-0.0014860517,
0.0081317015,
-0.013192174,
0.012237875,
0.008716377,
0.011565833,
0.033440784,
-0.012782228,
0.017903185,
0.006502001,
0.0008539127,
-0.035779487,
0.016908564,
-0.049032144,
-0.0039314427,
0.006290308,
-0.027795635,
-0.0077419174,
-0.016908564,
-0.006014771,
0.01995963,
0.002723448,
0.0074798213,
0.0032510005,
0.009045678,
-0.008951592,
0.026706928,
0.0010324237,
0.002770491,
0.007358854,
-0.018749956,
0.016572542,
-0.0036088626,
0.01831985,
-0.004314506,
-0.010604815,
-0.0031871565,
-0.0353225,
0.0074798213,
0.028575202,
-0.027768753,
-0.0033820486,
-0.011794328,
0.004892462,
-0.026680047,
-0.028494557,
0.0040154476,
-0.038843997,
-0.0048252577,
0.013568517,
-0.002935141,
0.0073790154,
-0.017338669,
-0.014852116,
0.021948874,
-0.014637063,
0.02189511,
-0.0021454925,
0.021680057,
0.007849445,
0.008817184,
-0.023951558,
-0.018521463,
0.008373637,
0.015806414,
0.045940753,
0.013702925,
-0.008098099,
-0.011579274,
-0.010228471,
-0.011713683,
-0.03779561,
-0.032822505,
0.018911246,
0.022688119,
0.016881682,
-0.002871297,
0.009590032,
-0.022499949,
0.008555088,
-0.010920674,
-0.0034610135,
-0.0054368153,
0.00029170798,
-0.0005430935,
0.016236521,
0.010114224,
-0.0028427353,
0.0037567117,
-0.014556418,
-0.021706939,
-0.043064415,
0.0009685797,
-0.0047110105,
-0.0013659243,
0.024018763,
-0.022002637,
0.013172013,
0.0072042844,
0.0034173308,
0.0005544342,
-0.012137068,
-0.012210993,
0.038843997,
-0.019381676,
-0.00940858,
0.018252647,
0.004845419,
-0.00389112,
0.0037264698,
0.004492597,
-0.021034898,
-0.041747216,
-0.00036689264,
0.01622308,
0.015107492,
0.00275537,
0.00010096373,
-0.021344036,
-0.01944888,
-0.029919285,
-0.03658594,
-0.004082652,
-0.02173382,
-0.013629001,
-0.005591385,
-0.0015591362,
0.025349405,
0.014005344,
-0.019516084,
0.0008182105,
0.035698842,
-0.021290272,
0.01815856,
-0.01637093,
0.012116907,
-0.008313153,
-0.00079132884,
-0.013541635,
-0.03440852,
0.017647808,
-0.026021445,
-0.034300998,
-0.0044690757,
-0.018400496,
0.027002625,
0.017325228,
0.00922713,
0.0063944743,
-0.013353464,
0.018481141,
-0.008440841,
0.00021095801,
0.041585926,
-0.03860206,
0.014462332,
-0.0000020000452,
0.013857495,
-0.020147802,
0.0034173308,
-0.010739222,
0.004637086,
0.008998635,
-0.013165292,
0.009670677,
0.012372283,
0.007083317,
-0.016801037,
-0.006391114,
0.007856165,
-0.006549044,
-0.003551739,
-0.00226814,
-0.013514753,
-0.022970377,
-0.019569848,
-0.00081443024,
0.0011038281,
-0.00070816366,
0.0013835654,
0.02900531,
-0.010241912,
-0.017446196,
-0.009899171,
-0.0033938093,
0.039462276,
0.0059576477,
-0.013830613,
-0.0004036449,
-0.0029889045,
-0.051155794,
-0.011874973,
-0.02012092,
0.003180436,
0.024569836,
0.03016122,
-0.0025554376,
0.0017641088,
0.0024697524,
0.005883723,
-0.0058736424,
-0.014099429,
0.009932773,
-0.009428741,
0.020860167,
-0.0005493939,
-0.025739187,
-0.02415317,
0.0101747075,
-0.006290308,
-0.016801037,
0.030887026,
-0.021115543,
-0.0034878952,
-0.010900512,
0.0070429943,
0.031827882,
0.0003013686,
-0.00068968255,
-0.023897795,
-0.026317144,
-0.011720403,
-0.01881716,
-0.020349415,
0.011223093,
0.00038369367,
0.017876303,
-0.0051814397,
-0.014166634,
-0.00681114,
0.009778203,
-0.035537552,
0.0131048085,
0.0307795,
-0.017755335,
0.0064415173,
0.023387043,
-0.0045732423,
-0.024717685,
-0.004684129,
-0.0050167893,
-0.011545672,
0.0090187965,
0.000017089804,
-0.0062432652,
-0.017889744,
0.0021421323,
-0.05024182,
0.014663945,
-0.009818526,
-0.017446196,
-0.027903162,
0.016303726,
0.0074529396,
0.016760714,
0.011612876,
-0.012452928,
-0.0021454925,
-0.00713708,
0.0010156226,
0.0037096688,
0.00039944463,
-0.016008027,
0.006350792,
-0.013044325,
-0.0152419,
-0.010598094,
-0.04330635,
-0.017150499,
0.023696182,
0.18591355,
-0.01766125,
0.005880363,
-0.0010189828,
-0.0057963575,
-0.015927382,
-0.0061054965,
-0.0014894119,
-0.005383052,
0.00891799,
0.010678738,
0.00040637507,
-0.0054267347,
-0.0033484465,
0.0037802332,
-0.028118216,
-0.016438134,
0.020483823,
-0.036532175,
0.008447561,
0.0043380274,
-0.006579286,
0.022997258,
0.010436804,
0.030403156,
0.0142607195,
-0.028360149,
-0.009361537,
0.0069959518,
-0.0037231096,
-0.038924642,
0.00019478702,
-0.002284941,
0.015268782,
0.025389727,
0.01006046,
-0.032714978,
0.0031905167,
0.0007589868,
-0.011740564,
0.0033971695,
0.019018773,
-0.001474291,
0.017029531,
-0.00794353,
0.02983864,
-0.00040259483,
-0.01247981,
-0.008360196,
0.0052721654,
-0.061881576,
0.006065174,
0.020188125,
0.01798383,
-0.010087342,
-0.0036088626,
0.011115566,
0.0030073854,
-0.020631673,
0.036532175,
-0.022405863,
0.009603472,
-0.033951536,
0.021680057,
-0.036236476,
0.041236464,
-0.019865546,
-0.026666606,
0.023844032,
-0.023481129,
0.021263393,
-0.013272819,
-0.02349457,
-0.02787628,
-0.025806392,
0.0065893666,
0.02495962,
0.022661237,
-0.0054872185,
0.003514777,
0.0049327845,
-0.031102078,
-0.014784912,
0.009106162,
-0.0023773466,
-0.045161188,
0.015188137,
0.0061357385,
-0.010456965,
-0.017244583,
0.006838022,
-0.008373637,
-0.012506692,
0.016505338,
0.002963703,
-0.016102113,
0.009502666,
-0.000062058825,
-0.0017111856,
-0.010477127,
-0.041774098,
0.06752673,
0.00089129497,
-0.0048554996,
-0.0058602015,
-0.00087449397,
-0.016895123,
0.026801012,
0.006068534,
-0.013709646,
0.014032226,
-0.027983807,
-0.0051142354,
-0.012681423,
-0.008413959,
0.012835992,
-0.017916625,
-0.015174696,
0.0275537,
-0.0076545523,
-0.0012105147,
-0.02545693,
-0.008145142,
0.021438122,
-0.022688119,
0.0056653093,
-0.016774155,
0.021975756,
-0.017795658,
-0.037392385,
0.016585983,
0.010907233,
0.018575225,
0.022755323,
0.00093917793,
-0.007150521,
0.012399165,
-0.009381698,
0.007903207,
-0.005756035,
-0.020846726,
-0.025591338,
0.0012676382,
-0.014569859,
-0.009206968,
-0.018118238,
0.025201555,
0.01716394,
-0.0041061733,
-0.024448868,
-0.015739212,
-0.030107457,
-0.01651878,
-0.010685459,
0.008723098,
-0.01637093,
-0.016868241,
-0.042473022,
-0.01313169,
0.0038944802,
-0.023682741,
0.037392385,
0.00761423,
-0.0076545523,
-0.02041662,
0.01328626,
-0.17032218,
0.010719061,
0.007553746,
-0.020497264,
0.032688096,
-0.0039516035,
-0.004895822,
-0.0030561085,
0.00534945,
0.0039314427,
0.039247222,
-0.00745966,
-0.023615537,
-0.028010689,
0.004848779,
0.0010836668,
0.0048252577,
0.035940778,
0.03661282,
-0.0075940685,
0.021196188,
-0.014905879,
0.033897772,
0.004973107,
0.006179421,
0.028467676,
-0.005154558,
-0.0042237807,
0.012358842,
-0.007029554,
-0.010974437,
-0.007567187,
0.038198836,
0.0051948805,
0.023561774,
-0.016733833,
0.000097813536,
-0.010430084,
0.0033854088,
0.003419011,
0.018051034,
0.029919285,
-0.0048991824,
-0.001848114,
-0.021706939,
0.021236511,
0.000056440982,
0.0043884306,
0.015631685,
-0.00129704,
0.010960996,
0.013830613,
0.020376297,
0.01798383,
0.0010080622,
0.020080598,
-0.0030292268,
0.013313142,
-0.020456942,
-0.017755335,
-0.013911258,
-0.0008362716,
0.028790256,
-0.005010069,
0.012379004,
-0.03061821,
0.0081317015,
0.010913953,
-0.01556448,
0.018225765,
-0.030994551,
0.007997293,
0.018064475,
-0.0129704,
0.023104785,
0.014395128,
-0.006142459,
0.027661227,
0.018400496,
0.015120933,
-0.011444866,
0.023521451,
-0.03456981,
-0.013239217,
-0.0022664599,
0.0064583183,
0.014865557,
0.016128995,
0.0025806392,
-0.00030892907,
0.030698854,
-0.027661227,
0.017849421,
-0.026827894,
0.02739241,
0.023696182,
0.013219056,
-0.0025319161,
0.0007014433,
-0.011209652,
0.009267452,
-0.011585995,
-0.004690849,
-0.0101747075,
0.038064428,
0.017970389,
-0.025913918,
-0.013252658,
0.037849374,
-0.018400496,
-0.004798376,
-0.002740249,
0.011001319,
0.024005322,
-0.014986524,
-0.006179421,
0.018588666,
-0.021155866,
-0.009952934,
-0.030430038,
0.06768802,
-0.008474443,
-0.031881645,
0.025309082,
-0.010846749,
-0.052768696,
-0.118924454,
-0.010047019,
0.0035752605,
0.022903172,
-0.013508033,
0.023454247,
0.008071218,
0.036666583,
0.0007556266,
0.027822517,
-0.02999993,
-0.011888414,
0.0002530656,
-0.0019304391,
-0.0056989114,
0.016128995,
0.010591374,
-0.006286948,
0.0019758018,
0.047983762,
-0.019032214,
-0.0045093982,
0.0115523925,
-0.0136424415,
0.0009542989,
-0.008501325,
-0.018521463,
0.009603472,
-0.0001328332,
0.020954253,
0.027352087,
0.002624322,
0.025026824,
-0.0022782206,
-0.019045655,
0.0073185316,
0.017271465,
-0.028252622,
0.029274127,
-0.0049899076,
-0.0071303598,
0.009778203,
0.0094623435,
0.012372283,
0.012667982,
0.0013860855,
-0.0056821103,
-0.0058736424,
0.018266087,
-0.028198859,
-0.027177356,
-0.020792963,
-0.040295605,
-0.011922016,
0.029435417,
-0.025228437,
0.0081317015,
0.038306363,
-0.03196229,
-0.01281583,
0.0031686756,
-0.0041263346,
-0.0074529396,
0.0001554096,
0.03938163,
-0.03258057,
-0.012849432,
-0.03922034,
0.023561774,
-0.015094051,
0.0015498956,
0.008857506,
-0.008991915,
-0.015161255,
-0.019395117,
0.0075268643,
-0.005262085,
-0.00729165,
-0.0013961662,
-0.014731149,
-0.022150487,
-0.014381687,
0.0017758695,
-0.015604802,
0.014395128,
-0.008958313,
0.019085977,
0.0030124257,
0.0007354654,
-0.012647821,
0.008279551,
0.052284826,
-0.006270147,
0.0031972372,
-0.00680778,
0.012943518,
0.012567176,
-0.006777538,
0.030026812,
0.019408558,
-0.026223058,
-0.038682707,
-0.057311695,
0.010645136,
-0.016599424,
-0.0093346555,
0.008313153,
0.0019186784,
-0.0036525454,
-0.007876326,
-0.00664313,
0.024865534,
0.0029687432,
0.00077368773,
-0.0030594687,
0.007869606,
-0.02107522,
-0.0005855161,
0.03142466,
-0.0062331846,
0.015672008,
0.023911236,
-0.00006531403,
0.012520133,
0.009112882,
0.011626317,
-0.014838675,
0.0020766081,
-0.015819855,
0.023521451,
0.011465027,
0.020067157,
0.006125658,
-0.04749989,
-0.00827283,
-0.00055023393,
-0.0105712125,
-0.018387055,
-0.001491092,
0.0096841175,
0.01815856,
0.015120933,
-0.02510747,
-0.016411252,
0.01313169,
0.012520133,
-0.0012516772,
-0.0023639058,
-0.022741882,
-0.0028309748,
0.0056888307,
-0.020564469,
0.032204226,
0.0069959518,
-0.023292957,
-0.018575225,
-0.012688143,
0.012452928,
0.0016666629,
0.009663956,
0.0108870715,
-0.023561774,
0.0113306185,
0.006333991,
-0.0049999882,
0.006417996,
0.0022160567,
-0.0005859361,
-0.0025671984,
-0.013756689,
0.026182735,
-0.014462332,
-0.03518809,
0.005803078,
0.016639747,
0.005769476,
0.006300389,
0.026518757,
0.0025688785,
-0.0131048085,
-0.020510705,
0.01313169,
0.012829271,
0.011881693,
-0.024448868,
0.009805085,
0.020147802,
-0.016424693,
-0.0122177135,
0.01944888,
0.018010711,
-0.001442369,
0.006061814,
0.023051022,
0.0034643738,
0.002837695,
0.0018867564,
0.01070562,
0.016720392,
-0.012513412,
0.009737881,
0.02900531,
-0.0025503973,
0.0068514626,
-0.020322533,
-0.013655882,
0.004180098,
0.024569836,
-0.04268807,
-0.031236487,
0.00013556336,
0.0103964815,
0.022997258,
0.0076881545,
0.00081947056,
-0.00029863842,
-0.011364221,
-0.010490567,
0.0043985113,
-0.01588706,
-0.0029855443,
0.026196176,
0.010920674,
0.012654541,
0.00001235795,
0.01474459,
0.005540982,
0.017849421,
0.041532163,
-0.033467665,
0.012694864,
-0.017903185,
0.052714933,
-0.020671995,
-0.043494523,
-0.005712352,
0.0044489144,
-0.009610193,
0.0062936684,
0.024180051,
-0.008252669,
0.08123637,
0.012923357,
-0.0014474093,
-0.0062936684,
0.0009450583,
-0.012681423,
-0.0053091277,
0.030268747,
-0.012903196,
-0.015658567,
0.0047244513,
-0.030994551,
0.020671995,
-0.016397811,
-0.031048315,
0.021975756,
-0.034677338,
0.020201566,
0.0033854088,
-0.0015851778,
0.032526806,
0.0051310365,
-0.0013348423,
0.0042069796,
-0.025416607,
-0.00092825724,
0.038951524,
-0.013857495,
-0.008198906,
-0.012862873,
-0.0025655183,
-0.009133044,
-0.027956925,
-0.0054569766,
0.014166634,
-0.02041662,
0.004180098,
-0.016478457,
0.034623574,
0.014784912,
-0.015577921,
0.014542977,
-0.023723064,
-0.020887049,
0.0023051023,
-0.0073790154,
-0.004428753,
0.0014978125,
-0.009448903
] |
PURPOSE Gleason score (GS), T stage, and pathologic lymph node status have been described as major independent predictors of death due to prostate cancer in men treated with external beam radiotherapy (XRT). In this analysis we combine these three factors to define prognostic subgroups that correlate with disease-specific survival (DSS) death from prostate cancer. METHODS AND MATERIALS Men entered on one of four Radiation Therapy Oncology Group (RTOG) Phase III randomized trials between 1975 and 1992, for clinically localized prostate cancer (CAP) (n = 1557), were selected for this analysis. Patients were | [
0.002278694,
-0.019896641,
0.0045675533,
-0.05136803,
-0.007881401,
0.018094016,
-0.014109267,
0.018853016,
-0.026470123,
-0.019368052,
0.0035510354,
0.031905103,
-0.004255821,
0.009677249,
-0.00019059709,
0.021536624,
0.028272748,
0.014515874,
0.02554848,
0.0024277833,
-0.015735695,
-0.0048047407,
-0.014163481,
-0.017253695,
0.02084539,
-0.004635321,
0.020343909,
-0.020398123,
0.024166016,
0.0065395976,
0.021563731,
-0.0059229103,
-0.041636568,
-0.023163052,
-0.017755177,
0.009412955,
0.00763066,
0.0004167723,
0.018500624,
-0.010971615,
0.007393473,
0.0023532386,
0.013960177,
-0.0062007583,
0.0020347298,
-0.016576016,
-0.010090633,
-0.014651409,
-0.017904267,
-0.0041202856,
0.008742053,
0.022010999,
-0.036621746,
-0.017822945,
0.0108293025,
-0.012489615,
0.02137398,
0.02417957,
0.0053265532,
-0.020479444,
0.011432436,
-0.029302819,
-0.022309177,
0.022729337,
-0.006966535,
-0.0012393045,
-0.0071698385,
0.011100374,
-0.0005972042,
0.029655213,
0.04087757,
0.036459103,
-0.02160439,
0.023230819,
0.0065802583,
-0.015234213,
-0.03147139,
-0.008308339,
0.022187194,
0.0061872047,
0.020858945,
-0.024545517,
0.00780008,
0.0073324814,
0.01526132,
-0.0001721727,
-0.006749678,
0.029140176,
-0.01715882,
0.006041504,
0.033124927,
0.0018026249,
0.015193553,
0.023623873,
-0.015274874,
0.011662847,
0.006715794,
-0.004150781,
0.00084625103,
-0.04627189,
-0.015301981,
-0.0021448524,
-0.01488182,
-0.010402366,
-0.0091079995,
-0.007603553,
-0.0013163905,
0.0077458653,
0.013397704,
-0.00579754,
-0.022729337,
0.03960353,
0.002141464,
-0.015369749,
0.021726374,
-0.016426926,
0.032230392,
0.0020093168,
-0.019842427,
-0.0033409551,
0.017484106,
-0.037055463,
0.053346854,
-0.022986855,
0.009074115,
-0.012103339,
-0.038898747,
-0.007603553,
0.0147056235,
-0.0037848346,
0.01315374,
-0.0017670467,
0.0036221917,
-0.009751794,
-0.0040694596,
0.00051122374,
-0.002373569,
-0.003954254,
-0.02493857,
-0.034073677,
0.008247348,
0.0065734815,
0.00819991,
-0.020411678,
-0.00803049,
0.010239722,
0.034561604,
0.01083608,
-0.012286312,
0.0067022406,
-0.013946624,
-0.014271909,
0.016494695,
-0.004936888,
-0.0062685264,
-0.02057432,
0.0077390885,
0.044401497,
-0.008498088,
-0.017362123,
0.016372712,
0.0133638205,
0.0049436647,
0.018256659,
-0.0030614126,
0.04122996,
0.015369749,
0.01654891,
-0.004350696,
-0.00051164726,
0.0027564573,
0.026199052,
-0.011181695,
0.013024981,
-0.00073104573,
0.03504953,
-0.016535357,
0.019151194,
-0.02137398,
-0.006180428,
-0.032203283,
0.0018873346,
0.030549748,
0.008111812,
-0.011473097,
-0.00091994856,
0.02464039,
-0.009019901,
-0.009656919,
-0.010124517,
0.011344339,
0.0014908927,
-0.0027005489,
-0.005875473,
-0.62715083,
-0.020560766,
0.015207106,
-0.0102736065,
0.02451841,
0.017294357,
0.008328669,
-0.0027903414,
-0.024816588,
0.016291391,
-0.015410409,
0.022160087,
-0.001277424,
-0.032176174,
0.0018365087,
-0.027784819,
-0.0062414194,
0.032067746,
0.015776357,
-0.000023626097,
-0.021631498,
0.013011428,
-0.021834802,
0.024586176,
-0.0023481562,
0.014204142,
0.0006755608,
-0.039196927,
0.0016145691,
0.008775936,
-0.030875033,
0.0060110083,
0.01799914,
0.013526463,
0.04456414,
-0.021414641,
-0.016616678,
0.00971791,
0.017646749,
0.057033423,
-0.02987207,
-0.0012986015,
0.016101642,
-0.0067022406,
-0.030658176,
0.02076407,
0.005109696,
0.009507829,
0.00017344335,
-0.012462508,
0.013052088,
-0.0024227006,
0.0011164753,
0.004201607,
0.0045607765,
-0.003574754,
0.028191427,
-0.021916123,
-0.016088087,
-0.014434553,
0.0059093568,
-0.009968651,
-0.000500635,
-0.0036120266,
-0.018771695,
0.023257926,
-0.016494695,
0.002061837,
0.019327391,
-0.006912321,
0.021089356,
0.01867682,
0.0020567542,
0.0076171067,
0.023352802,
0.017714517,
-0.0012088091,
0.018080464,
-0.016698,
-0.005258785,
0.005462089,
-0.0038729326,
-0.005116473,
0.0068140575,
0.019381605,
-0.015573053,
-0.004171111,
0.007576446,
0.02797457,
0.004357473,
-0.00012081737,
0.017213034,
-0.0065667047,
-0.0131605165,
0.011574749,
0.008152473,
0.009433285,
-0.014339677,
0.01639982,
-0.058171924,
-0.049145248,
-0.0237323,
0.02243116,
0.030088926,
0.012286312,
0.011398553,
-0.024247337,
-0.0069529815,
0.013126633,
-0.0086268475,
0.004221937,
0.004177888,
-0.014583642,
-0.0047064773,
-0.00819991,
-0.01393307,
0.018527731,
0.01924607,
0.011954249,
-0.031146105,
0.0020601428,
0.000121240926,
0.017511213,
-0.008538749,
0.024301551,
0.02725623,
0.022268517,
-0.003313848,
0.00054680184,
-0.0016060981,
0.00019673855,
-0.022498926,
0.013031758,
-0.015925445,
0.011269794,
-0.012022017,
0.0040186336,
-0.002763234,
0.0051639103,
-0.031552713,
-0.047654353,
-0.009121553,
0.0093858475,
-0.009819562,
-0.016386267,
-0.015939,
-0.02114357,
-0.010083856,
0.015003802,
-0.012997874,
0.009440062,
-0.010429473,
0.008674285,
-0.00020806848,
0.005340107,
-0.0023464619,
-0.0013274028,
-0.022607356,
-0.004221937,
-0.009616259,
-0.004842013,
-0.0028411672,
-0.003981361,
-0.012381187,
-0.015301981,
-0.03271832,
0.004282928,
0.034670033,
-0.00176027,
-0.028028784,
0.0072443835,
0.0017619642,
0.012218543,
0.012265981,
-0.008721722,
-0.0055163032,
0.007922062,
-0.017036838,
0.00878949,
-0.014109267,
0.008586187,
-0.010341374,
-0.014353231,
0.010646329,
0.033314675,
0.020289695,
0.0069529815,
0.0052147363,
-0.024355765,
0.0006120284,
-0.021834802,
0.02558914,
-0.020669194,
0.021536624,
-0.0041745,
0.007203723,
0.013695883,
0.004249044,
0.007962722,
0.017904267,
0.030197354,
-0.00076111767,
0.058605637,
-0.013655222,
0.018514177,
0.0013960177,
0.020343909,
-0.0062007583,
0.0008360859,
0.018405749,
0.016481142,
-0.011391776,
-0.02152307,
-0.00039580662,
-0.016277838,
0.011628963,
0.0011622186,
0.0048623434,
-0.0024210066,
-0.008877588,
-0.024681052,
0.00619737,
0.02710714,
0.005387544,
-0.029817855,
0.011750946,
0.019151194,
0.0014942811,
0.0017102911,
-0.025765337,
-0.012238874,
0.019137641,
0.020465892,
0.011019053,
0.002261752,
-0.010565008,
0.0022431158,
-0.012259205,
0.024193123,
-0.028055891,
-0.013594231,
-0.033070713,
0.032528568,
-0.020709855,
0.0049131694,
-0.0073324814,
0.015315535,
-0.0079695,
-0.013282499,
0.005634897,
-0.013648446,
0.031091891,
-0.022919087,
0.004703089,
0.025562033,
-0.0021990668,
-0.004011857,
0.026808962,
0.027269784,
0.0039034283,
0.043479852,
0.0007695887,
0.01954425,
0.0029563725,
-0.003237609,
-0.009331633,
-0.013668776,
0.002856415,
0.0047234194,
-0.010808973,
-0.0035713657,
-0.0023871225,
0.0032579396,
-0.026673427,
-0.00020309178,
0.005336718,
0.034046568,
0.021279106,
0.006905544,
0.013079195,
-0.0041473927,
-0.034019463,
0.021929678,
0.019801766,
-0.01273358,
-0.01148665,
0.0073595885,
-0.001035154,
0.003737397,
0.002805589,
0.020398123,
0.004747138,
0.012218543,
0.011208802,
0.0045336694,
-0.020249033,
-0.026144838,
-0.030603962,
-0.0003202031,
-0.011317232,
0.020547213,
0.008531973,
0.0033155421,
-0.03944089,
0.028489605,
0.016576016,
-0.042449784,
-0.027811926,
-0.013052088,
-0.018880123,
0.0017060557,
-0.029167283,
-0.0039983033,
-0.0074070264,
0.025684016,
-0.0021990668,
0.0026632766,
-0.018392196,
-0.0028496382,
0.006939428,
-0.012537053,
-0.023108838,
0.0041914415,
-0.015125784,
0.030387105,
0.03575432,
0.013526463,
0.010314267,
0.012259205,
0.0229733,
-0.0056992765,
-0.030983461,
0.023366354,
0.019083427,
0.009778901,
0.032365926,
-0.009087669,
0.014773392,
0.02300041,
0.023393463,
0.004360861,
-0.026551444,
-0.007976276,
0.0047539147,
-0.015247767,
-0.00090215955,
0.031444285,
0.03868189,
0.018012695,
-0.014475213,
0.010849633,
0.00181279,
0.0029919506,
-0.022065213,
-0.02422023,
0.025805999,
-0.007386696,
0.009141883,
-0.021265551,
-0.0031308748,
0.02664632,
-0.0138449725,
0.0055671292,
0.0034646315,
0.015505284,
-0.009534936,
0.0074951244,
-0.0054654772,
0.018798802,
-0.03412789,
0.0023091896,
0.023989819,
-0.005499361,
-0.013892409,
0.0029326538,
0.0013096137,
-0.018270213,
-0.016304946,
-0.00060694583,
-0.008186356,
-0.0012647175,
0.00023146957,
0.005116473,
0.0013595925,
-0.0042388793,
-0.015207106,
0.034832675,
0.0037475622,
-0.014488767,
-0.012875892,
-0.019869534,
-0.012360856,
-0.031010568,
-0.01469207,
0.020547213,
-0.0069868653,
-0.013783981,
0.003981361,
0.01393307,
0.000923337,
0.018527731,
-0.022024551,
-0.0033697565,
0.006231254,
-0.014434553,
0.028706461,
0.0032460801,
-0.014407446,
0.023488337,
0.023257926,
-0.011019053,
-0.0051876293,
-0.0147056235,
0.01085641,
-0.005041928,
-0.009521383,
-0.019788213,
-0.012699695,
0.0071088476,
-0.0027903414,
0.015342642,
0.031823784,
-0.0072714905,
0.006224477,
-0.0024040646,
-0.03201353,
-0.032908067,
-0.018243106,
-0.014055053,
-0.0027022432,
-0.0018229552,
0.0019144418,
-0.006522656,
-0.025236748,
0.015681481,
-0.02493857,
0.0090063475,
-0.009196098,
0.00855908,
0.015532392,
0.010700543,
0.025562033,
0.026808962,
0.0014087242,
-0.022322731,
-0.0143261235,
0.035944067,
0.0011732309,
-0.01583057,
-0.005265562,
-0.0017196093,
-0.013350267,
-0.03396525,
-0.016996177,
-0.010585339,
0.02133332,
-0.0023227432,
-0.036947034,
-0.0076442137,
0.007339258,
-0.009074115,
-0.0013799228,
-0.01639982,
-0.016372712,
-0.0125777135,
0.009351963,
-0.022200748,
0.0033358724,
0.04144682,
-0.022715785,
-0.03052264,
-0.0013036841,
0.0072376067,
0.004608214,
-0.021075802,
0.008091481,
-0.01768741,
0.0020753904,
-0.007894955,
-0.025602695,
0.0013146963,
-0.010409142,
0.020791177,
0.030875033,
0.025236748,
-0.009121553,
0.017104605,
0.031010568,
0.00068826723,
0.01939516,
0.00021389229,
0.0064345575,
-0.017402785,
0.01484116,
0.00257179,
-0.008247348,
0.0041067316,
-0.007291821,
0.023068177,
0.005956794,
0.020696303,
-0.022349838,
-0.012801347,
-0.035022426,
-0.031444285,
0.016860642,
0.00085683976,
0.014163481,
-0.05242521,
-0.007725535,
0.022404052,
0.0038085533,
-0.020357464,
-0.0252503,
0.011100374,
-0.0008674285,
-0.010151625,
-0.003574754,
0.0018161784,
-0.0055942363,
-0.00973824,
-0.011764499,
0.010924178,
0.0018382029,
-0.0077323117,
0.024044033,
0.012930106,
0.001691655,
0.007983053,
-0.0058619194,
-0.043561175,
-0.01218466,
-0.003046165,
-0.026510784,
-0.010978392,
0.0075222314,
-0.013831419,
-0.021238444,
0.0044252407,
-0.004496397,
0.014976695,
0.019761106,
0.0055095265,
-0.02698516,
0.018405749,
-0.002476915,
0.020533659,
-0.008850481,
0.029817855,
0.018053357,
-0.031118998,
-0.0106531065,
-0.0010859799,
0.02774416,
0.012997874,
0.008376107,
0.02251248,
-0.010504017,
-0.01890723,
-0.015234213,
0.027839033,
-0.026781855,
-0.022742892,
0.03724521,
-0.005041928,
0.0060821646,
0.002478609,
-0.012645481,
-0.049063925,
0.017145267,
0.00801016,
-0.0275273,
0.010436249,
0.0023769573,
0.0018195668,
0.022959748,
-0.02649723,
-0.009345187,
-0.01560016,
-0.008986017,
-0.008294785,
-0.02611773,
0.0038661559,
0.004255821,
-0.015166446,
0.034859784,
-0.0049944906,
-0.0076442137,
-0.0035510354,
0.013905963,
0.0016696304,
0.0025277408,
-0.00817958,
0.03667596,
-0.008586187,
-0.010327821,
0.0050758123,
-0.010056749,
-0.00027805998,
-0.0028157542,
0.0017890712,
0.0046387096,
-0.034670033,
-0.008057598,
0.040145677,
0.020709855,
-0.028218534,
0.0011257934,
-0.016372712,
-0.017822945,
0.0006590424,
-0.022051658,
-0.0020787788,
-0.040254105,
-0.0044150758,
0.0022515869,
0.0139195165,
0.023691641,
0.021550177,
-0.0005789916,
0.008843705,
0.030929247,
-0.010063526,
0.009372294,
0.01730791,
0.019368052,
-0.026470123,
0.002314272,
-0.02342057,
-0.036269356,
0.022607356,
-0.01488182,
-0.024301551,
-0.04835914,
-0.0037136783,
-0.009975428,
0.025724677,
-0.013777204,
0.004245656,
0.0024277833,
0.004445571,
-0.025724677,
-0.01148665,
0.027283337,
0.005428205,
-0.004391357,
0.0021533235,
-0.014936035,
0.008714946,
0.0022854707,
0.016738659,
-0.009019901,
-0.0042151604,
-0.00070393854,
-0.017904267,
0.014353231,
-0.007833963,
0.001975433,
-0.012049124,
0.0010376952,
-0.019761106,
-0.01677932,
0.0021685713,
0.0037441738,
0.011669624,
-0.032664105,
-0.01951714,
0.00933841,
-0.035401925,
-0.015112231,
-0.0141499275,
-0.012062677,
-0.028028784,
-0.024382873,
-0.010768312,
0.034453176,
0.02304107,
-0.014353231,
-0.01258449,
-0.02190257,
-0.017524766,
-0.014624302,
-0.013526463,
0.024247337,
0.026266819,
0.034371853,
-0.023027517,
0.02634814,
0.008660732,
0.004140616,
-0.014719177,
-0.04293771,
0.009467169,
0.004547223,
0.011567973,
0.010049973,
-0.023894945,
-0.023339247,
0.039115604,
-0.009114776,
-0.015464623,
0.0003168147,
-0.004709866,
0.0010461662,
-0.017755177,
0.016752213,
-0.022810658,
0.008416767,
-0.011845821,
-0.048304927,
0.0077797496,
0.01621007,
0.000002827521,
0.002546377,
-0.0069462047,
0.003574754,
0.01484116,
-0.011141035,
-0.003090214,
-0.0028784396,
0.0051368033,
0.010781866,
0.015058016,
0.044618353,
0.008565856,
0.014746284,
0.023407016,
0.015369749,
-0.001518847,
-0.017809391,
-0.025562033,
-0.0066005886,
-0.0043168124,
-0.034832675,
-0.007203723,
-0.0055976245,
0.012177883,
-0.0057839863,
0.0032240555,
-0.025263855,
-0.030495534,
-0.03781446,
0.042422675,
0.02422023,
-0.024843695,
-0.003063107,
0.0013672165,
-0.03071239,
-0.005048705,
-0.01431257,
0.017375678,
-0.038708996,
-0.0022261739,
-0.015058016,
0.014109267,
-0.011832267,
-0.008538749,
-0.0047945757,
-0.008836928,
0.00676662,
0.19387028,
-0.019720444,
-0.0049504414,
0.00024629378,
0.014136374,
0.0020516717,
0.04263953,
-0.004513339,
-0.0056721694,
0.01650825,
0.016684445,
0.00015501896,
-0.012360856,
0.00916899,
0.031444285,
-0.005153745,
-0.017822945,
-0.019042766,
0.00007369754,
0.0053129997,
0.013783981,
0.02987207,
0.009216428,
-0.0045031738,
0.028137213,
0.005678946,
-0.0058890264,
-0.0045336694,
0.03212196,
0.0073663653,
-0.01602032,
-0.012333749,
-0.0003610756,
0.0035103748,
0.0053739906,
0.0015010579,
-0.00819991,
-0.017213034,
0.001743328,
0.005387544,
0.006065223,
-0.007772973,
-0.012306642,
-0.016033873,
0.010382035,
-0.008281232,
-0.01734857,
0.011574749,
-0.01719948,
-0.006332906,
-0.030685283,
-0.00030749664,
0.032935176,
0.0031003791,
-0.006502325,
0.0141499275,
0.023691641,
-0.024382873,
0.00371029,
0.011900035,
-0.010348151,
0.0038797096,
-0.03819396,
0.033477318,
-0.008592963,
0.04112153,
-0.010937732,
0.013207954,
0.019218963,
0.0060448926,
0.009277419,
-0.007339258,
-0.013289276,
0.0039068167,
-0.023068177,
-0.018690374,
0.016074535,
0.008843705,
0.00011319349,
0.025385838,
0.01142566,
-0.00057263835,
-0.0007509525,
0.01148665,
-0.011554419,
-0.02023548,
0.021645052,
0.009745017,
-0.018378641,
0.021130016,
-0.00029627257,
-0.00195002,
-0.009866999,
-0.0044286293,
0.01726725,
0.012306642,
0.015315535,
0.015857678,
-0.007095294,
-0.018527731,
-0.033314675,
0.065057136,
0.019598464,
0.024545517,
0.00039813612,
-0.010808973,
-0.02133332,
0.034290534,
0.019191856,
-0.0064853835,
0.01878525,
-0.039278246,
0.020249033,
-0.014475213,
0.0143261235,
0.019639123,
0.010951285,
0.0015510367,
-0.010165178,
-0.03477846,
0.004520116,
-0.037868675,
0.0034764907,
0.0043134238,
-0.011154588,
-0.02630748,
-0.01806691,
-0.006404062,
-0.013451919,
-0.016657338,
0.009711133,
-0.02607707,
-0.012279535,
-0.0011749251,
0.010924178,
-0.00969758,
-0.009304526,
-0.0009733158,
-0.04030832,
0.031823784,
0.0030580242,
0.007881401,
-0.03621514,
0.012909776,
0.026998712,
0.0003458278,
-0.006363401,
0.004909781,
-0.02767639,
-0.010659883,
-0.03174246,
-0.004852178,
-0.018798802,
0.0141499275,
0.018974999,
-0.034968212,
0.0005696735,
-0.04486232,
0.010558232,
0.008552303,
-0.015003802,
-0.0034459953,
0.042531103,
-0.030739497,
-0.012428624,
0.022648016,
-0.17240141,
0.017375678,
0.019571356,
-0.022566695,
0.033043604,
0.00069758535,
0.043696713,
0.008992794,
-0.009311303,
0.0007060563,
0.021102909,
0.029058855,
-0.051991496,
-0.0032054193,
-0.0014375256,
0.0037780576,
-0.00031893246,
0.047003783,
0.02892332,
0.021861909,
0.011879705,
0.0034459953,
0.010029642,
-0.0027581516,
-0.0150851235,
-0.024911463,
0.00094874995,
-0.004249044,
-0.007095294,
-0.010192285,
-0.025155427,
-0.0111342585,
0.0015086818,
-0.01954425,
-0.006363401,
0.00022257504,
0.006515879,
0.002097415,
-0.0034375242,
0.008403214,
0.032636996,
0.022566695,
0.009833115,
-0.0018941115,
-0.018514177,
0.023718748,
0.021075802,
0.013255392,
0.025629802,
0.0035103748,
0.016941963,
-0.007474794,
0.00077636546,
-0.005963571,
0.004628544,
0.008145696,
-0.0019601851,
-0.0071766153,
0.01654891,
0.016318498,
-0.01810757,
-0.02649723,
0.022607356,
-0.014285463,
-0.02375941,
-0.028787784,
-0.02710714,
0.024897909,
-0.0016713246,
-0.0049775485,
-0.010131294,
0.014922481,
0.023244374,
-0.019557802,
0.02987207,
0.020818284,
-0.026144838,
0.011222356,
0.01692841,
0.0021821249,
0.011601856,
0.008470981,
-0.014868267,
0.0038966516,
0.0056145666,
0.015952552,
0.024111802,
0.016765766,
-0.004879285,
-0.023339247,
0.011601856,
-0.009290973,
0.009236759,
-0.0040254104,
-0.0035781425,
0.019842427,
-0.01049724,
0.005428205,
0.00063574716,
-0.02968232,
0.014420999,
-0.007129178,
-0.03063107,
-0.004957218,
0.015898338,
0.0064582764,
-0.009826339,
-0.0059703477,
0.021075802,
0.0009851751,
-0.0114392135,
-0.0037340086,
0.0147056235,
0.0051401914,
-0.00030813194,
0.028977534,
0.009745017,
-0.013167294,
0.0041846647,
-0.0047810217,
0.04429307,
-0.003185089,
0.004055906,
0.016101642,
0.011845821,
-0.01966623,
-0.11146456,
-0.007637437,
0.008423544,
0.036377784,
-0.009704356,
0.024138909,
0.004926723,
-0.0013087667,
-0.03743496,
0.046705604,
-0.0145294275,
-0.016657338,
-0.031173212,
-0.012401517,
0.037299424,
-0.026578551,
0.024437087,
-0.050202426,
-0.0077797496,
0.055217247,
0.009236759,
-0.018703926,
-0.0034358301,
-0.023027517,
0.0067700082,
-0.005716218,
-0.009731463,
0.00004690806,
0.000025346764,
0.009202874,
0.007447687,
-0.010565008,
0.015979659,
-0.0073528118,
-0.01890723,
-0.013472249,
-0.023962712,
-0.056165997,
0.041365497,
-0.0033646738,
-0.0031766181,
0.029600998,
0.01224565,
-0.0009529854,
0.0027767876,
-0.022227855,
-0.046136353,
0.014868267,
0.042720854,
-0.016101642,
-0.0013570512,
-0.034480285,
-0.0090063475,
-0.0054315934,
-0.0035781425,
0.002124522,
0.003098685,
0.0063905083,
0.00035069862,
0.014285463,
-0.017226588,
0.009412955,
0.0009809396,
0.023027517,
0.005421428,
-0.01985598,
-0.024857247,
-0.023488337,
0.008633625,
-0.016833534,
0.0018720869,
-0.013180847,
-0.026402354,
-0.0022820823,
-0.02824564,
-0.0067903385,
-0.018581945,
-0.005448535,
0.023298588,
-0.02569757,
-0.0064786067,
-0.0106531065,
0.024952123,
-0.016142303,
0.04274796,
0.001882252,
0.004360861,
-0.013207954,
0.0006238878,
-0.023556106,
0.005634897,
0.030983461,
-0.0002429054,
-0.023230819,
-0.005983901,
-0.004530281,
-0.012076232,
0.0066005886,
0.020967374,
0.013248615,
-0.032230392,
-0.009277419,
-0.060991067,
0.01966623,
0.005109696,
-0.014285463,
-0.007908508,
-0.017172374,
-0.00019186773,
-0.021807695,
0.023447677,
0.0021431583,
0.0034968213,
0.010991946,
-0.003564589,
0.005794151,
-0.01909698,
-0.028841998,
0.010795419,
0.013512909,
0.034182105,
0.024301551,
-0.011798383,
-0.0007259631,
-0.0057196068,
-0.0008835234,
0.011418883,
0.010212615,
0.0020160936,
0.038031317,
-0.025196087,
-0.028869106,
0.013960177,
-0.016372712,
-0.011683177,
-0.0023176605,
-0.0063769547,
-0.023718748,
0.008430321,
0.035944067,
0.023556106,
0.03735364,
-0.00857941,
-0.030387105,
0.020560766,
-0.017972033,
0.0006560775,
-0.000008490835,
-0.025684016,
0.025426498,
-0.015518839,
0.0020855556,
0.009833115,
-0.015193553,
0.0021363816,
-0.009060562,
-0.004825071,
0.0028513323,
0.016914856,
-0.006065223,
-0.03887164,
-0.0066141426,
0.022905534,
0.04003725,
0.00803049,
-0.011120705,
0.0056823343,
-0.022065213,
-0.011351115,
-0.00579754,
-0.01867682,
-0.024437087,
-0.03488689,
-0.0069597582,
0.0076577673,
0.03933246,
0.019029213,
-0.008870812,
-0.005933075,
-0.02236339,
-0.04342564,
0.008952133,
0.0115408655,
0.0066683567,
0.0010673436,
0.023705194,
0.021048695,
0.004150781,
-0.019883087,
0.041202854,
-0.013580677,
0.00400508,
-0.0053773792,
0.029736534,
0.01719948,
0.005526468,
0.010185508,
0.002234645,
0.004011857,
0.017443445,
0.021699267,
0.02152307,
-0.016237177,
-0.011913588,
-0.01583057,
-0.00676662,
-0.00541804,
0.0066581913,
-0.037218105,
-0.031552713,
-0.027432427,
0.01587123,
0.031308748,
0.011947473,
0.00032528568,
0.010937732,
-0.00655654,
0.00075899996,
0.010707321,
-0.0021821249,
-0.0075425617,
0.021048695,
0.025968641,
0.025182534,
0.0012562466,
0.009778901,
0.016847087,
-0.0021194397,
0.020967374,
-0.019910194,
0.017280802,
0.0011257934,
0.0034832675,
-0.02483014,
-0.03328757,
-0.007474794,
0.01408216,
-0.008667508,
0.0035374819,
0.024098247,
-0.0244913,
0.082026206,
0.019747552,
-0.026429461,
-0.0024108414,
-0.010382035,
0.015966106,
0.00035048687,
0.01966623,
0.006122825,
-0.05288603,
0.0139195165,
-0.012489615,
0.0036628523,
-0.023352802,
-0.013011428,
0.01802625,
0.019612016,
0.035022426,
-0.010436249,
-0.021306213,
0.027202016,
-0.020113498,
0.016426926,
0.0095891515,
-0.016454034,
-0.010158401,
0.022254962,
0.01446166,
0.023813624,
-0.026537891,
-0.0039745844,
-0.002219397,
-0.017375678,
-0.011127481,
0.015112231,
-0.0060787764,
-0.0043710265,
-0.059201997,
-0.009636588,
0.033206247,
-0.0104498025,
-0.012448954,
0.004730196,
-0.018392196,
-0.020899605,
-0.012238874,
-0.027012266,
-0.008328669,
-0.0022143146
] |
Administration of 0.5 mg bleomycin to mice twice weekly for 4 weeks induced pulmonary fibrosis. The initial site of injury was the intima of pulmonary arteries and veins where endothelial cells became edematous and were separated from the underlying basement membrane by large blebs. These lesions occurred after 2 weeks and were associated with infiltration of perivascular spaces by lymphocytes and plasma cells. Capillary endothelial blebbing and interstitial edema were observed after 4 weeks, when multifocal necrosis of type 1 alveolar epithelial cells was accompanied by fibrinous exudation into the alveoli | [
-0.034835964,
-0.003284238,
0.0023158304,
-0.032164495,
-0.027435994,
0.017471412,
-0.042663373,
0.023669222,
-0.022146484,
0.01128696,
-0.022413632,
0.01759163,
0.023455504,
0.029947177,
-0.006715407,
0.012469085,
0.020423386,
0.017471412,
-0.014279006,
-0.010365303,
-0.022841066,
0.022186557,
-0.0087691,
-0.006671996,
-0.008168018,
-0.007279755,
0.0155345965,
-0.024163444,
-0.010792738,
-0.020022666,
0.012722875,
-0.010652485,
-0.0045782314,
0.009176498,
-0.0046617147,
0.009316751,
0.0069391425,
0.0023191697,
0.018566715,
-0.0006595191,
0.012315475,
0.0023458845,
0.008635526,
0.016189106,
-0.015120518,
-0.017057335,
0.004554856,
-0.015547954,
-0.00021830917,
0.017097406,
0.025365606,
-0.01415879,
0.0126360515,
0.011727752,
-0.010946347,
-0.020717248,
-0.0001584098,
0.014946873,
-0.0023492237,
-0.0072931126,
-0.021251542,
-0.007867479,
-0.020877536,
-0.0025078421,
-0.032885794,
-0.0011069903,
-0.002759962,
0.03269879,
-0.019261297,
-0.0041741715,
0.04333124,
0.026781484,
0.013637853,
-0.013985144,
0.017671773,
0.0046784114,
-0.012602659,
-0.00024544128,
-0.0054130657,
0.0027082025,
0.01839307,
0.009296714,
-0.02206634,
0.046082854,
0.02085082,
-0.0062545785,
-0.0007718043,
0.001400852,
-0.013998502,
0.014118718,
0.014198862,
0.026794842,
0.0167234,
0.011447248,
-0.012075043,
0.011914755,
0.005606747,
0.027248992,
0.025285462,
-0.030855475,
0.0003462475,
0.0010285159,
-0.017604986,
-0.014172147,
-0.04341138,
0.0036565743,
0.006972536,
0.0009642336,
0.039831612,
-0.0030955656,
-0.015067089,
0.028023718,
0.009490396,
-0.04373196,
0.0078006918,
-0.0041775107,
0.0039537754,
0.009062961,
-0.005209366,
-0.020623747,
0.0064349025,
0.02473781,
0.013644531,
-0.015080446,
0.022627348,
0.003823541,
-0.0154811675,
-0.015788386,
0.011801218,
0.019060936,
0.02457752,
0.03812187,
0.017364554,
-0.027182205,
-0.009450324,
-0.00018001115,
-0.025499178,
-0.016696686,
-0.025125174,
-0.025939971,
-0.007399971,
0.02468438,
-0.010098156,
-0.0033026044,
-0.004528141,
0.028477868,
0.02322843,
0.0126494095,
-0.0002164308,
-0.004624982,
-0.018606788,
-0.031897347,
-0.023201715,
-0.0212649,
-0.01924794,
0.0077339048,
0.002242365,
0.020263098,
-0.01641618,
-0.0066886926,
-0.0047017867,
-0.0004816994,
0.030828761,
0.011594179,
0.0098977955,
0.018954078,
0.0055433,
-0.01632268,
-0.0021655601,
-0.0074934727,
-0.017110763,
0.013230454,
-0.021946125,
0.03283236,
0.02115804,
0.016656613,
-0.01184129,
0.014412579,
-0.0087691,
-0.03702657,
-0.03138977,
0.018753717,
0.02337536,
-0.0052327416,
-0.03149663,
0.0054531377,
0.017978992,
-0.019368155,
0.00478527,
-0.039056886,
0.008127946,
0.01188804,
-0.0154544525,
-0.029225878,
-0.63645095,
-0.0359847,
0.0008077022,
0.0068456414,
0.0060174856,
0.027890144,
-0.0011195128,
-0.021104611,
-0.01606889,
0.0112268515,
-0.003346016,
0.012816376,
0.016082248,
0.0052627954,
-0.0037400576,
-0.0033276496,
-0.017404625,
0.0030671812,
0.006568476,
-0.0057503385,
-0.0027516137,
0.009810973,
0.006591852,
0.027088704,
0.011721074,
0.023148285,
0.02121147,
-0.008375058,
-0.007192932,
0.040018618,
-0.02186598,
0.027182205,
-0.002629728,
0.008555382,
0.04765902,
-0.008301592,
-0.017351195,
0.0154678095,
0.025098458,
0.025312176,
0.0021071217,
0.00947036,
0.033607088,
-0.0154945245,
-0.012128472,
0.018980792,
0.014412579,
0.005740321,
0.0058471793,
0.023201715,
0.0008031106,
0.0025629413,
-0.02735585,
0.023402074,
0.0222667,
0.018099207,
0.016643256,
0.011093278,
0.008588775,
-0.0031673613,
0.007667118,
0.0003285073,
-0.018833863,
-0.03919046,
0.0062846327,
0.0065117073,
-0.023054784,
0.0065517793,
0.026687983,
0.010672522,
0.03184392,
0.02664791,
0.007032644,
0.008181376,
0.03032118,
0.021732407,
-0.005760357,
0.03240493,
-0.0024327072,
-0.0009149784,
-0.010171621,
-0.009543826,
-0.005019024,
0.020169597,
0.018873934,
0.008635526,
-0.027569568,
0.0111867795,
-0.011968184,
-0.0071061095,
-0.0013490922,
0.024350448,
-0.013677925,
-0.033740662,
-0.033233084,
0.023976441,
0.021198113,
0.017925562,
-0.023642506,
-0.009864402,
-0.012422334,
-0.015654813,
0.002297464,
-0.009590576,
0.024524093,
-0.008234805,
-0.030107465,
-0.017978992,
0.018513285,
-0.01632268,
0.013611139,
-0.0008540355,
-0.010392018,
-0.028584726,
0.005155937,
-0.022093054,
-0.022400273,
-0.0084485235,
0.0008256511,
-0.019368155,
0.011721074,
-0.0011186779,
0.014038574,
-0.000031932414,
0.020009309,
-0.008181376,
-0.0061777737,
-0.019060936,
-0.014011859,
-0.013945072,
-0.0036198415,
0.01888729,
0.019408228,
0.004257655,
0.015147233,
-0.009577219,
0.013437493,
0.0049655945,
0.003943757,
-0.027302422,
-0.007900871,
0.030828761,
0.018633502,
-0.009330108,
0.0048854505,
0.007039323,
-0.0078073703,
0.018312925,
0.021505332,
0.011801218,
0.0007814049,
-0.017190907,
0.0050824713,
0.031309627,
0.022226628,
-0.0020436745,
0.00016613203,
-0.029733459,
-0.012889842,
-0.007132824,
-0.0033410068,
-0.016162392,
0.00881585,
0.007179575,
-0.0019000828,
-0.0072330046,
0.0002727821,
-0.013905,
0.0026330673,
-0.019929165,
0.0074934727,
-0.014532795,
-0.012883163,
0.02277428,
0.010645807,
0.011507356,
-0.013784784,
-0.010866203,
-0.038308877,
0.0068089087,
0.004104045,
-0.021144683,
0.038923316,
0.023134928,
0.0287183,
0.01919451,
0.026848271,
0.008348343,
0.0073732566,
0.024350448,
0.004695108,
0.013564387,
-0.022587277,
0.008174698,
0.014225576,
-0.005656837,
0.012869805,
-0.0112936385,
0.017818702,
0.033473518,
0.024777882,
-0.014212219,
0.036652565,
-0.0009450324,
0.015401023,
-0.011654287,
-0.017698487,
-0.010091477,
0.03157677,
-0.0032358177,
0.0029486348,
0.018686932,
-0.014893444,
-0.009457003,
-0.004170832,
-0.011246888,
0.0021321669,
-0.021184755,
-0.0028785088,
0.0016195786,
-0.007199611,
0.011327032,
0.01843314,
0.0064415815,
-0.025766326,
-0.011093278,
0.02085082,
0.010338588,
0.01325049,
-0.033927664,
0.0032074333,
0.014011859,
0.040178906,
0.0015895244,
-0.009757543,
-0.0037100036,
0.008401772,
-0.0039337394,
0.027703142,
0.021425188,
0.010138228,
0.028691584,
0.016937118,
-0.0028067129,
-0.0013532664,
0.014172147,
0.0053663147,
0.024817955,
-0.025953328,
0.01224201,
-0.010912954,
0.009410252,
-0.011013134,
-0.009350144,
-0.024403876,
-0.026888343,
0.008668919,
0.020476816,
0.01475987,
0.0067588184,
0.037373863,
-0.00841513,
0.011273602,
-0.0072864336,
0.021184755,
-0.003773451,
-0.016549755,
0.0025312176,
-0.017965633,
-0.023014711,
-0.019755518,
0.002202293,
0.03424824,
-0.024871383,
0.043144237,
-0.00036190066,
0.005556657,
0.0016872002,
0.013003379,
0.0052661346,
-0.02575297,
-0.015227377,
0.014198862,
0.0071862536,
-0.006388152,
0.0029102324,
0.002876839,
-0.0012130142,
-0.009103033,
0.016990548,
0.002272419,
-0.001143723,
0.007940944,
0.010458804,
0.000045733268,
-0.016603185,
0.02992046,
-0.017084049,
0.012876485,
-0.019608587,
-0.0055132457,
0.0026931753,
0.010104834,
-0.011774503,
0.020369956,
0.030000605,
0.005760357,
-0.01148732,
-0.019608587,
-0.014826657,
-0.005990771,
-0.027168848,
-0.010939669,
-0.01228876,
-0.014826657,
0.0054698344,
0.004568213,
-0.0061978097,
0.020917607,
-0.027088704,
0.0032608628,
-0.03678614,
0.0042142435,
-0.016442897,
0.03406124,
0.0030070732,
0.0072129685,
0.0071061095,
0.013063487,
0.012368905,
0.003446196,
-0.014025216,
0.0098710805,
-0.006555119,
0.03339337,
0.0003241244,
0.020263098,
0.014920158,
0.025833113,
0.018967435,
-0.0016337708,
-0.044800546,
0.00856206,
-0.01712412,
0.0019752178,
0.0032892472,
0.037854727,
0.028477868,
0.0017598307,
0.0016771822,
0.018580072,
0.005960717,
0.0034729107,
-0.00821477,
-0.022293415,
0.022093054,
0.002327518,
0.021545403,
0.0036031448,
-0.035477117,
-0.0012631043,
-0.030054035,
0.022400273,
0.0076136887,
0.0025963346,
0.021491975,
-0.0033677216,
0.01475987,
-0.01350428,
-0.014412579,
0.0060742544,
0.0055800322,
-0.00021246533,
-0.018352997,
0.050624352,
-0.019929165,
-0.016963832,
-0.031550057,
0.011540749,
-0.002100443,
0.0073265056,
-0.013851571,
-0.008822529,
-0.010358624,
0.0032408268,
-0.023749366,
-0.012308797,
-0.017257694,
-0.023615792,
-0.01037866,
-0.01768513,
0.005920645,
-0.01788549,
-0.003783469,
-0.012829733,
-0.006685353,
-0.027622998,
0.011734431,
0.021451902,
0.0111867795,
0.023642506,
0.0031656916,
-0.0053629754,
0.010184978,
0.008067839,
-0.0033309888,
-0.008041124,
-0.020329885,
0.0007308974,
0.010472162,
-0.017337838,
-0.020530244,
-0.017257694,
-0.0048453785,
0.042048935,
-0.0099645825,
0.0024477341,
-0.017190907,
0.013624496,
0.006211167,
0.015721599,
0.024524093,
-0.0073331846,
-0.02402987,
0.022413632,
-0.02166562,
0.0011278611,
-0.0038869884,
-0.019982593,
-0.00916982,
-0.010118192,
0.006832284,
-0.011660965,
0.000033915145,
0.00584384,
-0.008849244,
0.01325049,
0.013824856,
0.03138977,
0.025325533,
-0.023535648,
0.005713606,
0.010452125,
0.0029085628,
0.025191959,
-0.009383538,
0.031363055,
-0.004287709,
-0.027916858,
-0.0007534379,
-0.0037500756,
-0.038522594,
-0.035744265,
0.010806095,
-0.0025161905,
0.017791988,
0.0047618947,
-0.02630062,
-0.036198415,
-0.0098710805,
0.0030755296,
-0.005596729,
-0.021278257,
-0.006241221,
-0.019408228,
0.018406427,
-0.0036665923,
-0.0010001315,
0.044987552,
-0.02781,
-0.02090425,
0.005499888,
-0.019782234,
-0.007079395,
0.00039612886,
0.010258444,
-0.0085286675,
0.01244237,
-0.03400781,
-0.023295216,
-0.016255893,
-0.027783286,
0.019101009,
0.029386166,
0.026687983,
-0.01642954,
0.022787636,
0.019635303,
0.0018917345,
0.01839307,
-0.0008682277,
0.02569954,
-0.010612413,
0.024110014,
-0.006972536,
0.011901397,
0.018713646,
-0.033019368,
0.028745014,
0.027035274,
-0.01930137,
0.01606889,
-0.012736232,
-0.020490173,
-0.027275706,
0.0054631555,
0.010285159,
0.0054531377,
-0.035022967,
-0.026928416,
0.02166562,
0.0042242617,
0.0033810788,
-0.00921657,
0.016923761,
-0.015908603,
0.016082248,
-0.026861629,
0.01083281,
0.02413673,
-0.0154277375,
-0.004367853,
-0.025539251,
-0.0045982674,
0.021238184,
-0.02473781,
-0.007012608,
0.0020987734,
-0.018366354,
-0.027435994,
-0.016442897,
-0.011213494,
-0.003940418,
-0.005696909,
-0.007773977,
0.0021505333,
-0.0035931268,
-0.03777458,
-0.010124871,
0.008789135,
-0.01637611,
0.019635303,
-0.012322154,
-0.02615369,
0.01123353,
-0.036705993,
0.008982817,
-0.035049684,
0.035583977,
0.039350748,
-0.027916858,
-0.015120518,
-0.0053462787,
0.0009350144,
0.0022273378,
0.022600634,
0.013397421,
-0.028798444,
0.0008799154,
0.0077339048,
0.024043228,
-0.0007421677,
-0.026941773,
0.02775657,
-0.013530994,
-0.021852622,
-0.015347593,
-0.028130576,
-0.03860274,
0.012629373,
-0.019328084,
-0.007359899,
0.012943271,
-0.008909351,
-0.009891117,
0.0020236382,
-0.007486794,
0.021398474,
0.0013040112,
-0.0040940274,
-0.017551556,
0.012001578,
-0.019715447,
0.0058705546,
-0.013771427,
0.019929165,
-0.0030387968,
-0.0023258484,
0.0043745316,
0.0019418246,
-0.008001052,
-0.020436743,
-0.007874157,
0.04431968,
0.0003364382,
-0.0036165023,
-0.011567464,
0.018780433,
-0.007566938,
-0.028130576,
-0.013971787,
-0.024203517,
-0.006271275,
0.009350144,
0.01496023,
0.02423023,
0.0037200216,
-0.0009984619,
-0.023268502,
-0.008495274,
-0.006207828,
-0.017190907,
0.00594402,
-0.05334925,
-0.015053732,
-0.00428103,
0.0000846835,
0.020543603,
0.0009099694,
0.0054297624,
0.0068656774,
0.016389467,
-0.037560865,
0.0051158643,
-0.011093278,
0.021558762,
-0.035503834,
-0.011480642,
-0.020343242,
-0.0126360515,
-0.026313977,
-0.0029469652,
-0.031897347,
-0.010038048,
-0.032351498,
0.010986419,
-0.0042442977,
-0.040125474,
0.032725506,
-0.0045782314,
0.0067988904,
-0.025485821,
0.0014826657,
0.0083550215,
-0.022106413,
0.012275403,
0.009490396,
-0.004150796,
-0.01728441,
0.019475015,
-0.011407176,
-0.018406427,
-0.00962397,
-0.016750116,
-0.01586853,
0.002866821,
-0.019635303,
-0.023201715,
-0.023549005,
-0.012709517,
-0.016977191,
0.006999251,
-0.0013741372,
-0.0010351945,
-0.013617817,
0.011026491,
-0.008174698,
0.014986945,
-0.018914007,
-0.008314949,
-0.01677683,
-0.0077806558,
0.0113069955,
0.00061986444,
-0.021772478,
0.049342047,
-0.0059506986,
0.010231729,
-0.0068857134,
-0.01959523,
-0.039056886,
-0.018580072,
-0.005149258,
0.008702313,
-0.0020787374,
0.009684077,
0.011747789,
0.01793892,
-0.014185504,
0.0027866769,
-0.019915806,
-0.016536398,
0.02946631,
-0.015962033,
0.023188358,
0.004765234,
-0.028077148,
-0.02010281,
0.016509684,
-0.0014267318,
-0.010953026,
0.017671773,
0.0008548703,
-0.0154945245,
0.0036565743,
0.0003266289,
0.011854647,
-0.0068656774,
0.0020536925,
-0.02573961,
0.020516887,
0.00685232,
-0.007192932,
-0.022039626,
-0.015815102,
0.02957317,
0.007139503,
-0.0098176515,
0.004544838,
0.0075936527,
-0.0043511563,
-0.02604683,
0.0063113472,
-0.0018867255,
-0.02388294,
0.024297018,
0.014038574,
-0.013043451,
-0.020196311,
0.0051225433,
-0.02564611,
-0.012121794,
0.013290562,
-0.0106792,
-0.0066586384,
0.012782983,
0.011173422,
-0.017297767,
-0.013156989,
-0.0009233267,
-0.004140778,
-0.0052227234,
0.029332738,
0.017257694,
0.010906275,
-0.03350023,
-0.026394121,
-0.012809698,
-0.011600858,
-0.011854647,
0.010999776,
-0.024804596,
-0.012449049,
0.004337799,
-0.0034128027,
0.0049255225,
0.005032381,
0.014145432,
-0.006912428,
0.032004207,
0.18700288,
-0.02010281,
-0.0027666409,
0.011594179,
-0.01632268,
-0.015093804,
0.0052928496,
0.0076537607,
-0.015628098,
0.019728804,
0.021785837,
-0.018807147,
-0.020316528,
-0.0003604397,
0.014746513,
-0.013530994,
-0.010752666,
0.0024878061,
-0.013784784,
-0.01828621,
-0.00020349085,
-0.00518933,
0.025419034,
0.019181153,
0.02610026,
-0.0034929467,
-0.03724029,
0.026073545,
0.026340691,
0.011694359,
0.011614215,
0.011059885,
-0.008635526,
-0.005586711,
0.011273602,
-0.0019000828,
-0.011814575,
-0.021839265,
0.002427698,
0.022373559,
0.0063514193,
0.022894496,
-0.039698042,
0.008067839,
-0.02337536,
0.029145734,
-0.009797615,
-0.020276455,
-0.024871383,
-0.019515086,
-0.03203092,
0.011534071,
0.0034294992,
0.010592378,
0.009062961,
-0.028077148,
0.009590576,
0.01521402,
0.002759962,
0.0175382,
-0.024417233,
0.0062946505,
-0.020743962,
0.018165994,
-0.016295966,
0.02992046,
0.0015452782,
-0.02201291,
0.009136426,
-0.0034495352,
0.009310072,
0.0009325099,
-0.018593429,
0.02368258,
-0.027783286,
-0.016883688,
0.0049655945,
0.028424438,
0.016669972,
0.021518689,
0.0036866283,
-0.012475763,
-0.0443464,
0.013370706,
-0.008348343,
-0.036038127,
0.021972839,
0.021184755,
-0.01928801,
0.003596466,
-0.004040598,
-0.0022056322,
-0.010418732,
0.030241037,
0.046269856,
-0.008301592,
-0.0023792777,
0.018593429,
-0.01828621,
0.009336786,
-0.03769444,
0.07864807,
0.033847522,
-0.01995588,
0.010465483,
0.021184755,
-0.014466009,
0.0240833,
-0.018379712,
-0.004811985,
-0.012883163,
-0.022854423,
0.0127028385,
-0.0155212395,
-0.009697435,
0.02252049,
0.010819453,
-0.029680029,
0.01728441,
-0.0049589155,
-0.032004207,
-0.011701037,
0.028504582,
-0.011113314,
-0.027315779,
-0.004160814,
-0.023562362,
0.024791239,
-0.01415879,
-0.036652565,
-0.008041124,
0.0115875,
-0.009770901,
0.006131023,
0.024430592,
0.031149337,
-0.0072463616,
-0.013384064,
-0.011099957,
0.0031673613,
0.002659782,
-0.012402298,
0.007880836,
0.018272853,
-0.0061644167,
-0.010532269,
0.037721153,
0.004711805,
-0.027329136,
-0.015093804,
-0.032324784,
-0.022480417,
0.0036665923,
-0.028103862,
0.013958429,
-0.045521844,
-0.0067821937,
-0.01939487,
-0.010351946,
-0.0039537754,
-0.035690837,
0.014185504,
0.013931715,
-0.013163667,
-0.0008093719,
0.01143389,
-0.1683026,
0.008668919,
0.02997389,
0.017645057,
0.01990245,
0.0035897875,
-0.015267449,
-0.020089453,
-0.021371758,
0.0049054865,
0.028958732,
0.012522514,
-0.0049488978,
-0.022560563,
0.0071461815,
0.010886239,
-0.0062812935,
0.030187609,
0.041434497,
-0.0048654145,
0.02957317,
-0.029599885,
-0.0012731223,
-0.02664791,
0.013283883,
-0.0028067129,
0.0154678095,
-0.006932464,
-0.0063414015,
-0.006732104,
-0.03149663,
-0.006201149,
0.03518326,
-0.012068365,
0.012108437,
-0.0035630728,
-0.012469085,
-0.028290864,
-0.0017798668,
0.036599137,
0.049288616,
0.035797693,
-0.0043945676,
-0.008608812,
-0.04685758,
0.01646961,
0.012308797,
0.0020770677,
0.031443197,
0.0038736311,
0.014880086,
-0.0127562685,
0.0007133659,
0.029947177,
-0.0007667953,
0.03275222,
0.005309546,
0.0019134402,
-0.0010093147,
-0.007139503,
-0.0041574747,
0.007907551,
0.02130497,
-0.0012405638,
0.0010602395,
-0.035049684,
0.0052327416,
-0.009076319,
-0.004688429,
0.00018710723,
-0.010392018,
-0.045094408,
0.0048253424,
-0.03213778,
0.03577098,
0.024564164,
-0.006715407,
0.008308271,
-0.006628584,
0.019715447,
-0.013918357,
0.055139136,
-0.010285159,
-0.015734958,
-0.010786059,
0.041755073,
-0.011754467,
0.015694885,
-0.016482968,
-0.009290036,
-0.0011721073,
-0.035129827,
0.0012347199,
0.0018633502,
0.021598833,
0.017217623,
0.01002469,
-0.0074066496,
-0.003960454,
-0.0024494037,
0.02700856,
-0.0059106266,
-0.007647082,
0.017458055,
0.031630203,
0.0045014266,
-0.010131549,
0.0014676386,
0.039163746,
-0.01899415,
-0.011847968,
-0.003743397,
0.008101232,
0.009383538,
0.005476513,
-0.006328044,
0.013343992,
-0.0019318066,
-0.00312395,
-0.039430894,
0.057169452,
-0.0022490437,
-0.015721599,
0.044853978,
-0.010692557,
-0.007139503,
-0.12641394,
-0.02513853,
-0.00032808987,
0.039270606,
0.014813299,
-0.001541939,
-0.003940418,
0.019087652,
0.00841513,
0.023121571,
0.0036832888,
0.0050423993,
-0.011193458,
-0.008996175,
0.026714697,
-0.0064983503,
0.009684077,
0.0062812935,
-0.031122623,
0.03259193,
-0.031256195,
0.0007112788,
-0.0010210023,
-0.015320879,
0.018820504,
0.0028901964,
-0.024310375,
0.034408532,
0.00664862,
0.016816903,
0.021545403,
-0.013744712,
-0.002252383,
0.011300317,
-0.0073665776,
-0.021371758,
0.00438455,
-0.023068141,
0.034087952,
-0.032351498,
-0.0007876662,
0.011714395,
-0.0023659205,
-0.01430572,
-0.004404586,
-0.0043912283,
-0.038255446,
0.014986945,
0.0043010665,
-0.013931715,
-0.006835623,
-0.023161642,
-0.011053206,
0.0068990705,
0.021144683,
-0.003536358,
0.015734958,
0.018927364,
-0.02337536,
0.004952237,
0.03237821,
-0.014011859,
-0.018152637,
0.024951527,
0.01964866,
-0.0343551,
-0.02215984,
-0.018165994,
0.010772701,
-0.022907853,
-0.0052427594,
0.01717755,
-0.0011495668,
0.0031373072,
-0.02457752,
-0.017364554,
0.0077873343,
-0.013257168,
0.010285159,
-0.01854,
-0.010973062,
-0.007039323,
0.010445447,
0.0026731393,
0.015267449,
0.025071744,
0.012709517,
0.007179575,
0.005359636,
0.01063245,
-0.010812773,
0.025111815,
0.0019985933,
-0.026340691,
0.0110866,
0.015748315,
-0.014412579,
-0.027970288,
0.034942824,
0.025352247,
-0.018312925,
-0.011153386,
-0.050383918,
0.017551556,
-0.007239683,
0.022226628,
0.020797392,
-0.0003410298,
0.025819754,
0.00428103,
0.007339863,
-0.006892392,
-0.028184006,
0.021919409,
-0.011767824,
-0.011013134,
-0.0057503385,
-0.015107161,
0.013637853,
0.022333488,
0.005032381,
0.01712412,
0.006388152,
0.017297767,
-0.009263322,
0.010946347,
0.0011604197,
-0.013677925,
-0.0072530406,
0.03304608,
-0.0250851,
-0.012889842,
-0.004795288,
-0.03633199,
-0.010993098,
-0.020717248,
-0.008909351,
-0.01037866,
-0.013357349,
0.023402074,
0.011554107,
0.014466009,
0.0155746685,
-0.011473962,
0.019982593,
0.0048019667,
0.00008917074,
0.011173422,
-0.022106413,
0.016536398,
0.0083283065,
-0.013731355,
0.028558012,
-0.0039103637,
-0.019101009,
-0.02382951,
-0.02211977,
0.012990022,
-0.0021855962,
-0.014025216,
0.008608812,
-0.028130576,
0.022654064,
0.010973062,
-0.015775029,
0.0053028674,
0.009062961,
-0.011988221,
-0.0032525144,
-0.0021655601,
-0.000433279,
-0.015588026,
-0.020490173,
-0.013631174,
0.007867479,
0.012629373,
0.006555119,
0.009123069,
-0.0057904106,
0.016576469,
0.00020077765,
0.014653011,
0.011126672,
-0.013444171,
-0.024817955,
0.00176317,
0.03179049,
0.005399708,
0.0049155043,
0.016629899,
0.0015636446,
-0.018713646,
0.0017397946,
0.010745987,
0.006087612,
-0.0020887554,
-0.012422334,
0.027836714,
0.016603185,
0.0083617,
-0.009971261,
0.028397724,
0.0018049118,
0.009062961,
-0.0077873343,
-0.008388415,
-0.036251843,
0.0009291706,
-0.0042042257,
-0.035931267,
-0.015254092,
0.026327334,
0.0113069955,
0.017551556,
-0.015053732,
0.018379712,
-0.012629373,
-0.000677468,
-0.010759344,
-0.0006862338,
0.0022340165,
0.042396225,
-0.014906801,
0.016149035,
-0.002372599,
0.01022505,
-0.014332435,
0.014279006,
0.041300923,
-0.01093299,
0.010652485,
0.0039337394,
0.012161866,
-0.01128696,
-0.03002732,
0.0023308573,
0.019755518,
-0.029626599,
0.02660784,
0.020717248,
-0.0043745316,
0.059734065,
-0.00916982,
-0.025606038,
0.010619092,
-0.018112564,
0.016563112,
0.0061343624,
0.025525894,
0.00352634,
-0.0436251,
0.013671246,
-0.009650685,
0.0036131628,
-0.03627856,
-0.056154296,
0.0042643338,
-0.002272419,
0.014572867,
-0.0021488634,
-0.008001052,
0.024403876,
-0.024310375,
0.012589301,
0.007794013,
-0.025485821,
0.009550504,
0.017845418,
-0.0027649712,
-0.0060442,
-0.016336037,
-0.0085420245,
0.0012338851,
-0.03173706,
-0.022760922,
0.008535346,
-0.017404625,
-0.011313674,
-0.02181255,
-0.0052427594,
-0.001642119,
-0.021532046,
0.035450403,
-0.030508185,
-0.017645057,
-0.020663818,
-0.013838213,
-0.028958732,
0.0018633502,
-0.012435691
] |
Cells are equipped with a cell-intrinsic signaling network called the DNA damage response (DDR). This signaling network recognizes DNA lesions and initiates various downstream pathways to coordinate a cell cycle arrest with the repair of the damaged DNA. Alternatively, the DDR can mediate clearance of affected cells that are beyond repair through apoptosis or senescence. The DDR can be activated in response to DNA damage throughout the cell cycle, although the extent of DDR signaling is different in each cell cycle phase. Especially in response to DNA double strand breaks, only a very marginal response was observed during mitosis. Early on it was recognized that cells which are irradiated during mit | [
-0.041304518,
-0.0024301668,
-0.022887813,
-0.029035585,
-0.02123776,
0.020971624,
0.0058317347,
0.013839142,
0.0062475745,
0.012362081,
0.011031394,
0.01584848,
-0.005605518,
0.019135276,
-0.007544994,
0.010665455,
0.0325486,
0.016806575,
-0.0037425566,
0.009061977,
-0.030020295,
-0.007997428,
0.01881591,
-0.009002096,
0.02276805,
0.0074252323,
-0.007638142,
-0.03917542,
-0.007598222,
-0.0071990155,
-0.005924883,
-0.010978166,
0.008296832,
-0.0018696149,
0.0006262545,
0.009481143,
0.019494561,
-0.010845098,
0.021570433,
-0.021690195,
0.0032086186,
-0.0030073521,
-0.008210338,
-0.0077978247,
0.0042049703,
0.013692767,
0.009228313,
-0.018296944,
0.0026480667,
0.017179167,
0.023805987,
0.010459199,
-0.03747214,
-0.001610131,
-0.010818483,
-0.017990885,
0.0059548235,
0.022116015,
-0.011610243,
-0.010552347,
-0.019321572,
-0.013499818,
-0.023034189,
0.023020882,
0.0021174555,
0.018842526,
0.032947805,
0.020026837,
-0.0010470842,
0.0015618936,
0.045003828,
0.018802604,
0.009081937,
0.0215039,
0.0011868062,
-0.027598444,
-0.021131307,
-0.0032867964,
0.0152496705,
0.012601604,
0.027971037,
0.00013837064,
0.006759889,
0.012335466,
0.01563557,
0.007391965,
-0.01648721,
0.021437364,
0.011417293,
0.0024983645,
-0.0068197697,
0.02115792,
0.0043180785,
0.017405383,
-0.007278857,
0.012388694,
0.01831025,
0.013087304,
-0.016074697,
-0.0155424215,
-0.01542266,
0.011909647,
0.011603589,
-0.009195046,
-0.031670347,
0.0052861534,
0.020213133,
0.0022821277,
0.0020442675,
-0.01602147,
-0.009035363,
0.031430822,
-0.010246288,
-0.044205416,
0.025602413,
-0.0013714391,
0.023553155,
0.008409941,
-0.015569036,
-0.009042017,
0.013353442,
0.029248497,
0.038004413,
-0.022488607,
0.0155424215,
0.02294104,
-0.015316205,
0.008263565,
-0.009640826,
0.0172457,
-0.004012021,
0.02175673,
0.008216991,
0.007930893,
-0.022195855,
-0.0071391347,
-0.010505772,
-0.001563557,
-0.017112631,
-0.018057419,
0.021437364,
0.016473902,
-0.0282904,
-0.012242318,
0.011377372,
0.0079442,
0.022461994,
0.012481842,
-0.006959492,
-0.0021972966,
0.00036718638,
-0.021397443,
0.012914315,
-0.0344914,
-0.00530944,
0.022581754,
0.004431187,
0.009521064,
-0.0176316,
-0.020199826,
0.034384947,
0.000562631,
0.006590226,
0.007205669,
0.014291576,
0.03326717,
-0.005535657,
0.0016924673,
0.0051530846,
-0.024670932,
-0.004857007,
0.030153362,
-0.02158374,
0.020159906,
-0.034172036,
0.02511006,
0.015063374,
0.025695562,
-0.013326828,
-0.002551592,
-0.012541723,
0.009175085,
0.020000223,
-0.014504486,
-0.019694164,
-0.008882334,
0.014291576,
-0.0020625645,
-0.0076714093,
-0.027651671,
-0.0055888845,
-0.0012608258,
-0.0017282295,
-0.015742024,
-0.62297434,
-0.015063374,
-0.0023120684,
0.011616896,
0.012262279,
0.04189002,
0.0047572055,
0.008456514,
-0.0070659467,
0.014850465,
-0.023499928,
-0.0077246367,
0.014730703,
-0.021424057,
-0.03582209,
-0.028796062,
-0.015475888,
0.00070152147,
0.023672918,
0.0037059628,
-0.01602147,
-0.0093946485,
-0.028742835,
0.022834586,
-0.014331496,
0.0035762207,
0.01623438,
-0.004078555,
0.0012333803,
0.044711076,
-0.031989712,
-0.004208297,
0.0069994126,
0.022289004,
0.039521396,
0.0037059628,
0.00087991665,
0.033719603,
0.01410528,
0.052908108,
-0.013486511,
0.010013418,
0.032442145,
0.0065070586,
-0.021557126,
0.008216991,
0.014278269,
-0.010079953,
0.022368845,
0.01121769,
0.006450504,
0.023885828,
-0.02226239,
0.027412148,
0.031138072,
0.023819294,
0.004717285,
-0.0053061135,
0.014983533,
-0.0033400238,
0.01538274,
0.027012942,
-0.009421263,
-0.021557126,
-0.02413866,
0.0040153475,
-0.02646736,
-0.00036697846,
0.007325431,
-0.0047538783,
0.029301723,
0.019640937,
0.0096873995,
-0.0023170584,
-0.0042581977,
0.022807973,
-0.0018596348,
0.019135276,
-0.0059781102,
0.049608003,
-0.0015876757,
-0.03411881,
-0.024018897,
-0.0030189957,
0.02361969,
-0.015861787,
0.0018862485,
0.012501802,
-0.00143132,
-0.0029391544,
0.011018086,
-0.01848324,
0.0023752758,
-0.033959128,
0.010685415,
0.021424057,
-0.019281652,
0.0054458356,
-0.01580856,
-0.012734673,
-0.023420088,
-0.008083922,
-0.0046374435,
0.014624248,
0.010572307,
-0.0043679792,
-0.05977445,
-0.01212921,
0.06541656,
-0.009374688,
-0.0073520443,
0.006497078,
0.006064605,
-0.0050233426,
0.003248539,
-0.013652846,
0.037791505,
0.027385535,
-0.0015244681,
-0.019294959,
-0.005838388,
-0.030046908,
0.01865623,
-0.02400559,
0.027252465,
0.008822453,
0.014025439,
-0.0034631123,
-0.008489782,
-0.0063207624,
-0.007831092,
-0.00864281,
-0.003132104,
-0.0077645574,
-0.007604875,
0.009354728,
0.0008940552,
-0.00771133,
0.012262279,
-0.03712616,
-0.038989123,
-0.0126348715,
0.007698023,
-0.013300215,
-0.013745994,
0.0050266692,
-0.032016326,
0.010725335,
0.0022937714,
0.0046574036,
0.027598444,
0.0010420941,
-0.021982946,
0.004278158,
-0.0023702858,
-0.011064661,
-0.017698135,
-0.0255758,
-0.009926924,
-0.020199826,
0.007817785,
-0.008130496,
-0.010971513,
0.011443906,
-0.008350059,
-0.020638952,
0.005798468,
-0.01852316,
-0.012288893,
-0.023233792,
-0.0001490785,
-0.0007921745,
-0.01886914,
0.0133467885,
0.017990885,
0.02834363,
0.006593553,
0.0021008218,
-0.0028826003,
-0.0001369152,
0.011344105,
-0.018895753,
-0.011457213,
-0.015183136,
0.013559698,
0.025070138,
0.048463613,
0.008429901,
0.011177769,
0.009507757,
-0.010665455,
0.0123221595,
-0.015622263,
0.011670123,
0.00009491539,
-0.014610941,
-0.0073387376,
-0.009541024,
0.008416594,
0.050832234,
0.012189091,
-0.02158374,
0.026866566,
-0.015795251,
0.011703391,
0.003243549,
0.017099325,
-0.022887813,
0.019640937,
-0.010079953,
-0.01079187,
0.0019028821,
-0.017046098,
-0.018855833,
-0.0077445973,
0.011477173,
-0.007438539,
0.008449861,
-0.020758715,
-0.001345657,
-0.0016450615,
0.00050940353,
0.030951776,
-0.020492576,
0.0050399764,
0.012528416,
0.0011527074,
0.039281875,
0.0044578006,
0.0008641147,
0.001781457,
0.0018879119,
-0.01869615,
0.014251656,
0.0019527829,
0.014770623,
-0.016913028,
-0.0014013795,
0.04117145,
-0.017112631,
-0.0025349583,
0.018416705,
-0.008296832,
-0.004607503,
-0.008869028,
-0.010765256,
0.034651086,
0.019933688,
-0.021809956,
0.020918397,
-0.018789297,
0.019601017,
-0.06041318,
0.00439792,
-0.013719381,
-0.012036062,
0.021783343,
0.014916999,
0.043566685,
0.001498686,
0.022887813,
0.0065669394,
0.016833188,
-0.003559587,
0.0028326996,
0.020665566,
0.026866566,
0.0038856054,
-0.02927511,
0.018709457,
0.014730703,
-0.021703502,
-0.0041949903,
-0.018430011,
0.024804002,
0.011716697,
0.0103460895,
0.0077512506,
0.014637555,
-0.0036460818,
0.0071790554,
-0.024564479,
0.023433395,
0.033799443,
-0.01737877,
-0.016088003,
-0.024351569,
0.003238559,
0.0033400238,
-0.004770512,
-0.0043180785,
0.0317768,
0.0036294481,
0.021184534,
-0.0152496705,
-0.008609544,
0.011643509,
-0.01457102,
0.023672918,
0.005931536,
0.028849289,
0.0063407226,
0.00025116713,
-0.009015403,
0.039441556,
0.0066700676,
0.024271727,
0.009773894,
0.0006798978,
-0.035529338,
-0.004394593,
0.0071125207,
-0.0006021358,
-0.034863994,
-0.0007489272,
-0.0015718738,
-0.00017330116,
-0.0073320842,
0.010951553,
0.02514998,
-0.026094768,
-0.030153362,
0.001078688,
-0.035875317,
0.027837968,
0.032388918,
-0.013918984,
-0.0028360263,
-0.015582343,
0.0060779117,
0.0020858515,
-0.04936848,
0.030100135,
-0.031670347,
-0.00286763,
0.0019843867,
0.0066700676,
0.0099801505,
-0.0022139302,
0.025429424,
0.019188503,
-0.019747391,
-0.020811941,
-0.0038523383,
0.008902295,
-0.011071314,
0.027358921,
0.0435933,
0.022595061,
-0.0014936959,
0.0009738964,
0.0123953475,
-0.0012441921,
-0.006051298,
-0.0048370464,
0.039627854,
0.018363478,
0.009314807,
-0.019720778,
-0.022102708,
0.00067324436,
-0.0049900752,
0.012455229,
-0.0063507026,
0.017711442,
-0.0068131164,
0.023406781,
-0.0065868995,
0.014970226,
0.00017725164,
0.0037259231,
0.003493053,
-0.017019484,
-0.0073520443,
0.021557126,
-0.033453465,
-0.032335687,
-0.0304195,
-0.006091219,
-0.005668726,
-0.002955788,
-0.007917587,
0.0023819294,
0.008562969,
-0.0076115285,
-0.0064571574,
0.023526542,
-0.017711442,
-0.003285133,
0.006666741,
0.00947449,
-0.021716809,
-0.011270917,
0.005602191,
-0.020638952,
-0.02154382,
-0.023433395,
0.030951776,
0.0366205,
0.0097605875,
0.011557015,
-0.00046116614,
-0.015196444,
0.021969639,
-0.013459897,
-0.025868552,
-0.015063374,
-0.026959714,
-0.01835017,
0.026161302,
0.018749377,
-0.0020908415,
-0.042156156,
0.020891782,
0.016394062,
-0.012648178,
0.019893767,
-0.005103184,
-0.013553045,
0.032335687,
0.021823263,
0.020825248,
0.015103295,
-0.01652713,
-0.0039288527,
-0.023180563,
-0.01881591,
-0.016606972,
-0.000780531,
-0.0476652,
0.0038856054,
0.027518602,
0.0022654943,
0.011517094,
0.0012275586,
-0.0011734994,
0.0064604846,
-0.015555728,
0.0081504565,
0.02948802,
0.023885828,
0.006111179,
-0.017698135,
0.0030505995,
0.0041550696,
-0.037951186,
0.032601826,
0.01259495,
-0.0069661452,
0.01457102,
-0.011510441,
-0.010033378,
-0.033799443,
-0.01592832,
-0.0013107265,
0.03773828,
0.0064604846,
-0.028742835,
-0.003632775,
0.019574402,
0.011803192,
0.017112631,
-0.0016059726,
-0.008290179,
0.008416594,
0.006583573,
0.015795251,
-0.01865623,
0.0155424215,
-0.032096166,
-0.009580945,
0.01567549,
0.02123776,
0.011929607,
-0.007877666,
-0.008576277,
-0.018709457,
0.0024850576,
-0.010525732,
-0.047691815,
0.012242318,
0.00219896,
0.04880959,
0.033586536,
0.010765256,
0.0076115285,
0.00030397877,
0.018829217,
-0.0017997539,
-0.028476696,
-0.013047384,
-0.0075849146,
-0.010958206,
0.012821167,
-0.0046973242,
-0.016088003,
0.0158884,
-0.016886415,
0.019002207,
0.006872997,
0.013286907,
-0.03518336,
-0.0011593609,
-0.038057644,
-0.0029408177,
0.02544273,
-0.0059182295,
-0.0010254605,
0.0050366493,
0.016181152,
0.029967066,
-0.0032834697,
0.0122489715,
-0.0015128246,
0.018576387,
-0.0076581025,
0.01755176,
-0.005761874,
0.023047496,
-0.016540436,
-0.014557714,
0.009334768,
0.011596936,
0.009767241,
0.008323446,
0.010379357,
0.00085579796,
-0.017139247,
0.0060945456,
-0.020040143,
-0.009607559,
-0.04737245,
-0.019933688,
-0.017072711,
-0.020040143,
-0.0019610997,
-0.0068031363,
-0.03731246,
0.002022644,
-0.00016529625,
-0.013486511,
0.016247686,
0.008130496,
-0.01057896,
0.021344217,
-0.0062342677,
0.010372704,
-0.019547788,
0.02005345,
-0.0031054902,
0.0023403454,
-0.00947449,
-0.026733497,
-0.005931536,
0.01520975,
0.03377283,
0.017871123,
-0.0135863125,
-0.014131893,
-0.00947449,
0.0026014927,
-0.003586201,
-0.025070138,
0.0050233426,
0.024378182,
0.008669425,
-0.005232926,
-0.007591568,
-0.022834586,
-0.0080772685,
-0.005216292,
0.010605574,
0.0224753,
-0.004231584,
-0.008323446,
0.021557126,
-0.016088003,
0.022914426,
-0.01431819,
-0.026227837,
-0.006207654,
-0.012315506,
0.014304883,
-0.0048004524,
-0.0025998293,
0.017179167,
-0.02145067,
0.004876967,
0.018123955,
0.021557126,
0.0075849146,
-0.0067366017,
0.0073054703,
0.04380621,
-0.0027079475,
0.0037891306,
0.0070925606,
0.0010221337,
-0.009361382,
0.014730703,
-0.0022388806,
-0.00060671003,
-0.03853669,
-0.008170417,
0.0123953475,
0.001016312,
-0.011610243,
-0.0025965027,
-0.026733497,
-0.01127757,
-0.028955745,
-0.02685326,
0.040479492,
-0.030179976,
-0.031005003,
0.012987503,
0.011849766,
0.029434793,
0.010266248,
0.024271727,
-0.0026879874,
0.026786726,
-0.007977467,
0.028609766,
0.01520975,
-0.0012392021,
-0.01567549,
0.032096166,
0.0016858139,
-0.028982358,
0.014943613,
-0.017751362,
-0.02999368,
-0.014238348,
-0.012661485,
0.012295546,
0.015569036,
-0.03127114,
0.018283637,
0.0012899345,
0.02145067,
0.004677364,
-0.025908472,
0.010918285,
-0.027172625,
0.014304883,
0.012954236,
0.000363028,
-0.02813072,
-0.015688797,
-0.021171227,
-0.0010030052,
0.019853847,
-0.034810767,
-0.016966257,
0.001921179,
-0.020652259,
0.00088989676,
-0.008236951,
-0.013266947,
-0.031883255,
0.014424644,
0.0015228047,
-0.0010612227,
0.007817785,
0.009933577,
0.015183136,
0.031989712,
-0.0110247405,
0.003456459,
-0.004890274,
-0.029727543,
-0.020678872,
-0.0040852083,
-0.02001353,
0.0242185,
0.020758715,
0.015396046,
-0.021996252,
-0.027731514,
-0.01848324,
-0.020638952,
-0.0011884696,
-0.0057685273,
0.004574236,
0.025895165,
-0.00054932415,
0.009068631,
0.01214917,
0.026786726,
0.014131893,
-0.013306868,
0.011211036,
0.0009389659,
0.028822675,
-0.004770512,
-0.0067765224,
-0.016766654,
0.01346655,
-0.014464566,
-0.0152496705,
0.012841128,
0.005262866,
0.0112975305,
0.008988789,
0.003271826,
0.00032165195,
0.014717396,
0.0072588963,
0.0020292974,
-0.009061977,
0.0018696149,
0.009946884,
-0.036354363,
0.010193061,
0.011377372,
0.027279079,
-0.004876967,
-0.032521985,
-0.025429424,
0.002278801,
-0.041996475,
0.008902295,
0.008190378,
-0.006380643,
0.013852449,
-0.0042581977,
-0.0106588015,
-0.014890385,
-0.03419865,
-0.024963684,
-0.008004081,
0.0040752282,
-0.0034863993,
0.0016217745,
-0.0011319155,
0.0016350814,
-0.015795251,
0.016913028,
-0.010991473,
-0.0033233901,
-0.050619327,
0.034810767,
-0.012761286,
0.0043313857,
-0.016181152,
0.0013439937,
-0.020585725,
-0.016873108,
0.00025553344,
0.009860389,
-0.013153839,
-0.0044844146,
-0.00038901798,
-0.0063141086,
0.01013318,
-0.007777864,
-0.007558301,
-0.013513125,
0.013759301,
0.19502546,
-0.011197729,
0.012861088,
0.018190488,
-0.0013448254,
0.002510008,
0.015529115,
-0.006054625,
-0.01652713,
0.01257499,
-0.0020292974,
0.004311425,
0.00020178617,
-0.0016217745,
0.03419865,
0.0039055657,
-0.003902239,
0.0053659943,
-0.008569623,
0.0015702104,
0.013519778,
-0.011517094,
-0.003948813,
-0.0047305916,
0.012914315,
-0.003855665,
-0.026653657,
-0.005838388,
0.013918984,
0.008236951,
-0.021916412,
0.00068821455,
-0.005339381,
0.006992759,
0.0135863125,
-0.0061610797,
-0.017392077,
-0.02307411,
-0.010106566,
-0.013825836,
0.018057419,
0.0041650496,
-0.0290622,
-0.0016575367,
-0.004208297,
0.008283526,
0.0054824296,
-0.03148405,
0.015555728,
-0.017072711,
-0.05301456,
-0.013386709,
0.02166358,
0.023539849,
0.0066368002,
-0.010425931,
0.002696304,
-0.0117366575,
-0.015515808,
0.016034776,
-0.029913839,
-0.00045617606,
-0.018922366,
0.02544273,
-0.013666153,
0.00574524,
-0.017219087,
0.033480078,
0.0282904,
-0.022794664,
-0.014704089,
-0.006028011,
-0.025136674,
-0.006590226,
-0.021943025,
-0.000008154355,
0.006217634,
-0.00037404773,
0.025881859,
0.011557015,
0.012242318,
0.0024201865,
-0.03228246,
0.017312234,
0.0028643033,
-0.009740627,
0.02357977,
0.014158508,
-0.013453243,
-0.0024434736,
0.008656117,
-0.018376784,
-0.013533085,
0.0010395991,
-0.016447289,
-0.010186408,
0.00053684897,
0.0062708617,
-0.018536467,
-0.002510008,
-0.038350392,
0.08500427,
-0.0049102344,
-0.00175817,
-0.02553588,
0.008928908,
-0.0074119256,
0.014544407,
-0.01059892,
-0.021437364,
0.006054625,
-0.022195855,
0.029008972,
0.0034863993,
-0.00994023,
0.023473315,
-0.007525034,
-0.041357744,
0.030951776,
0.0031953116,
-0.008063962,
-0.0317768,
-0.01881591,
0.022887813,
-0.014384724,
-0.0040519414,
-0.028104106,
-0.0010712029,
0.010279556,
-0.025136674,
-0.012049369,
-0.022235775,
0.012827821,
0.0176316,
0.011390679,
-0.0016092993,
0.02702625,
-0.020971624,
-0.027465375,
0.0023220484,
-0.005622152,
0.0015336166,
0.010286209,
0.018962286,
-0.011423946,
-0.007864359,
0.024311647,
0.027678285,
-0.029833999,
0.004231584,
-0.026320985,
-0.008762573,
0.007937547,
-0.006111179,
0.005272846,
-0.034518015,
-0.02664035,
-0.011197729,
0.017352156,
0.028662993,
-0.024923764,
0.009787201,
-0.0021241088,
-0.014610941,
-0.019215118,
0.004604176,
-0.16638908,
0.025429424,
0.024311647,
-0.03135098,
0.04202309,
0.02047927,
-0.0018396745,
0.016673505,
-0.0026197897,
0.020213133,
0.021051465,
-0.0055789044,
-0.027704898,
-0.04404573,
-0.01015314,
0.012920969,
-0.003225252,
0.038377006,
0.0010670444,
0.017232394,
0.011397332,
-0.019494561,
0.0133467885,
0.0015053394,
0.00074851135,
0.01478393,
-0.008283526,
-0.019308265,
0.005688686,
-0.018842526,
-0.010199714,
0.0066434536,
0.000067573936,
-0.00081296643,
0.0075383405,
-0.019694164,
-0.008170417,
0.0047206115,
0.00020480102,
0.0076115285,
0.012262279,
0.022914426,
-0.0023087417,
-0.008769226,
-0.012887701,
0.04354007,
0.0038822787,
-0.022741437,
0.014557714,
-0.015941627,
0.029754156,
-0.02447133,
-0.0012300536,
0.023486622,
0.009567638,
0.013905677,
-0.00011996973,
-0.00040752284,
-0.0031720246,
-0.007890972,
0.005781834,
0.009361382,
0.04194325,
0.0020409408,
0.003285133,
-0.025655642,
-0.014118587,
-0.006324089,
-0.03127114,
0.013998825,
-0.02115792,
-0.030552568,
0.018084034,
-0.02935495,
0.027239159,
-0.0030921835,
-0.0052362527,
-0.0026347598,
-0.014637555,
-0.00811719,
-0.026307678,
0.035795476,
-0.020386122,
-0.03276151,
-0.02307411,
-0.013812529,
0.010984819,
0.03385267,
0.00265472,
-0.0030605795,
0.021876492,
-0.0075649545,
0.01145056,
-0.027465375,
0.022089401,
0.0106388405,
-0.009680746,
-0.005602191,
-0.010099913,
-0.0065303454,
-0.002774482,
-0.006297475,
-0.007312124,
0.014837158,
-0.007145788,
0.0021141286,
-0.013087304,
-0.00949445,
0.021304296,
0.003549607,
-0.020705486,
-0.00020864753,
0.006899611,
0.014557714,
0.019601017,
0.019774005,
-0.0067366017,
0.029887225,
-0.017006177,
-0.022714823,
0.08378004,
0.0029358277,
-0.022488607,
0.023020882,
0.0064837714,
-0.03614145,
-0.13541068,
-0.01077191,
-0.0036460818,
0.01890906,
0.010539039,
0.01015314,
0.01255503,
0.032867964,
-0.018802604,
0.023127336,
-0.040852085,
-0.015316205,
-0.019401414,
-0.00530944,
-0.0119562205,
-0.015116602,
0.0059648035,
-0.0030738865,
-0.018669536,
0.025895165,
-0.017738055,
-0.0014047063,
-0.014211735,
-0.0046174834,
-0.0073520443,
-0.0072722035,
-0.027731514,
0.010625534,
0.009680746,
0.019334879,
-0.004717285,
0.013945597,
0.023912441,
-0.0065769195,
-0.027279079,
-0.012754633,
-0.01610131,
-0.030286431,
0.014770623,
-0.020891782,
0.0033050934,
0.0054757763,
0.005226272,
-0.005924883,
0.007950854,
0.001501181,
0.0058816355,
0.020599032,
0.006769869,
-0.006853037,
-0.027651671,
0.0003106322,
-0.03491722,
-0.01081183,
0.0000816605,
-0.035236586,
0.02540281,
0.008230298,
-0.0129276225,
0.013260294,
0.014557714,
-0.0068796505,
-0.016154537,
0.009567638,
0.034172036,
-0.019747391,
-0.030366272,
-0.0047106314,
0.024098737,
-0.007006066,
0.00949445,
0.01009326,
-0.011290877,
-0.0053061135,
-0.010738642,
0.01344659,
-0.017272314,
-0.014158508,
-0.010672108,
0.004464454,
-0.006872997,
-0.02999368,
0.018855833,
-0.026054848,
0.031537276,
-0.01212921,
-0.01720578,
-0.01962763,
0.010645495,
-0.0065968796,
-0.019334879,
0.039973833,
-0.016779961,
0.0076248352,
-0.012255626,
0.0238326,
0.01406536,
-0.001273301,
0.0036028344,
0.022368845,
-0.02336686,
-0.0010803513,
-0.041783564,
0.012761286,
0.0059548235,
-0.0020426041,
0.0035995077,
-0.016966257,
-0.0005909081,
0.001306568,
0.024364876,
0.011703391,
-0.007664756,
-0.0050965305,
-0.0038989123,
0.0024833942,
-0.030446114,
-0.04372637,
0.017817896,
-0.017445303,
0.012142517,
0.04053272,
-0.018922366,
-0.015901707,
0.032069553,
-0.01606139,
0.00864281,
-0.016260993,
0.00012069745,
0.0051663914,
-0.015262977,
-0.018057419,
0.015821867,
-0.036514044,
-0.022807973,
-0.022461994,
-0.03292119,
-0.025668949,
-0.018802604,
0.03305426,
0.0019311592,
0.015342819,
-0.028929131,
-0.027132703,
0.007837745,
-0.0048969276,
-0.0077712107,
-0.0019644264,
-0.036806796,
-0.012375387,
-0.0031537276,
-0.029887225,
0.043061025,
0.008888988,
-0.0063307425,
-0.012189091,
-0.0045343153,
-0.008143803,
-0.0030090155,
-0.022076095,
-0.009953537,
-0.045269966,
0.0054391823,
0.017325543,
0.018403398,
-0.0019378127,
-0.009254927,
-0.022581754,
-0.033213943,
-0.019601017,
-0.004634117,
-0.026999636,
-0.011244304,
0.025908472,
0.030818706,
-0.014198428,
0.0027811355,
-0.005346034,
-0.005548964,
-0.018469933,
-0.008516395,
0.0047871456,
0.002528305,
0.008489782,
-0.016606972,
-0.00045908694,
0.046653878,
0.001278291,
-0.0255758,
0.012501802,
0.025416117,
0.00085039204,
-0.011517094,
0.018443318,
0.024418103,
-0.0008204516,
0.019241732,
0.026054848,
-0.014757317,
0.012588297,
0.011051354,
0.01997361,
0.023340246,
0.006127813,
0.008383327,
-0.014424644,
0.0037359032,
0.03861653,
-0.006324089,
-0.02162366,
-0.016074697,
0.007651449,
0.0059049227,
0.011224343,
0.008190378,
0.011796539,
-0.0023054148,
0.020612339,
0.011350758,
0.0047871456,
0.0010204704,
0.03228246,
0.019960301,
0.008855721,
0.006081239,
0.0077445973,
0.023393475,
0.011503788,
0.008483129,
-0.016340833,
0.020732101,
-0.0057652006,
0.04457801,
0.00006513088,
-0.01737877,
-0.018017499,
0.006939532,
-0.017431997,
0.005016689,
0.021996252,
-0.018642923,
0.09293517,
0.01958771,
-0.019960301,
0.0031104803,
-0.019481255,
0.020599032,
-0.0139322905,
-0.006676721,
-0.027598444,
-0.04175695,
0.025642334,
-0.020159906,
0.027545217,
-0.0162743,
-0.016593665,
0.039574627,
-0.016593665,
0.007165748,
-0.0004628295,
-0.033826057,
0.020772021,
-0.015622263,
0.0007821943,
0.014411338,
-0.00015354878,
-0.007824439,
0.009042017,
-0.007571608,
0.011503788,
-0.020146597,
0.035928544,
-0.032894578,
-0.040133514,
-0.004234911,
-0.0010470842,
-0.008210338,
0.0026780071,
-0.022847893,
0.006746582,
0.021357523,
-0.009348075,
0.0051663914,
-0.01852316,
-0.053466994,
0.006008051,
0.01584848,
-0.0042947917,
-0.01881591,
-0.00092815404
] |
Geostatistics is concerned with estimation and prediction problems for spatially continuous phenomena, using data obtained at a limited number of spatial locations. Model-based geostatistics refers to the application of general statistical principles of modelling and inference to geostatisatical problems. This volume is the first book-length treatment of model-based geostatistics. | [
-0.011879382,
-0.007928441,
0.014037458,
-0.006643556,
-0.0012973361,
0.01660059,
-0.01830049,
0.014196824,
-0.020770658,
-0.04387868,
0.0004197874,
0.038911782,
-0.04132883,
0.013094545,
-0.013194148,
0.012204753,
0.04786282,
0.007915161,
0.004641525,
0.00093461317,
-0.016481064,
0.024157178,
0.0027390972,
-0.049164306,
-0.010212682,
0.02370564,
0.02903111,
-0.028393649,
0.010856786,
0.012908618,
-0.014303068,
-0.01916372,
-0.024170458,
-0.015113177,
-0.02391813,
-0.018114563,
0.012211394,
-0.02506025,
-0.01464836,
-0.004820811,
0.0010325566,
-0.00083915977,
-0.0037816144,
-0.029456086,
0.05405152,
0.022590082,
0.016613869,
-0.022111986,
-0.026348455,
0.0040073823,
0.004578443,
0.046534773,
-0.03915083,
-0.00056400505,
0.0066966778,
-0.004870613,
-0.012649649,
-0.040638242,
-0.0047710096,
-0.061621387,
-0.0068128817,
-0.0014318009,
-0.018685624,
0.0022610002,
-0.01436947,
-0.019389488,
-0.027756186,
0.0069456864,
-0.009754506,
0.026016444,
0.011739937,
0.01915044,
-0.0037716539,
-0.0069788876,
0.035405736,
-0.018353611,
0.0003917739,
-0.0017248013,
-0.012490284,
0.015232701,
-0.015153018,
-0.023625959,
-0.0025249496,
0.0326434,
0.0074237837,
0.006062535,
-0.016082652,
0.01128176,
-0.022417435,
-0.004867293,
-0.012795734,
0.00451536,
0.020119915,
0.0061621387,
-0.0042099096,
0.0006109017,
0.005099701,
0.022669764,
0.018247368,
-0.016534187,
-0.016932601,
0.019615257,
-0.01637482,
-0.015352225,
-0.02927016,
0.007463625,
0.035405736,
0.0114212055,
0.022895534,
0.010571255,
-0.020332402,
0.017782552,
0.012901978,
-0.005544597,
0.021580767,
-0.0038214556,
0.03150128,
-0.0037417728,
-0.0071913754,
-0.01887155,
0.0011678515,
-0.010644298,
0.036494736,
0.009927153,
0.020212878,
-0.011009511,
-0.039469562,
-0.00787532,
-0.012085229,
-0.0180216,
-0.034741715,
0.00028241752,
-0.024675116,
0.017649747,
-0.029721696,
-0.0013089564,
-0.01324063,
-0.0067962813,
-0.023532996,
-0.038433686,
0.0012234634,
0.0139046535,
0.0039077788,
-0.005594399,
-0.017809112,
0.023147862,
0.03694627,
0.031740326,
0.0025813917,
-0.0075433077,
0.019455891,
-0.020199597,
-0.00010821509,
0.024993848,
-0.008273734,
-0.007463625,
0.0019970508,
0.00930961,
-0.010232603,
-0.017623186,
0.013041423,
0.017981758,
0.013957775,
0.010378689,
0.019562135,
0.026135968,
-0.009900591,
-0.01494053,
-0.019097319,
0.00093129306,
-0.014329629,
0.03641505,
-0.036972832,
0.019455891,
0.02676015,
0.0049702167,
-0.01494053,
0.01713181,
-0.0095685795,
-0.012735972,
-0.00032516406,
0.00563756,
-0.015378786,
0.0126629295,
-0.0041169464,
-0.0061521786,
0.030252915,
0.023333788,
0.0071780947,
-0.004595043,
0.012032107,
-0.004727848,
0.012377399,
-0.003125891,
-0.6429873,
-0.032005936,
0.004170068,
-0.041275706,
0.007005449,
0.0037052515,
0.021514364,
-0.007848758,
-0.004624924,
0.018366892,
-0.00013726612,
0.021607326,
-0.0006416128,
-0.011055993,
-0.03043884,
-0.028606135,
-0.029084232,
-0.022975216,
0.031023182,
0.0014077299,
-0.028951429,
0.017769272,
-0.012291077,
0.031023182,
-0.009316251,
0.041488193,
0.015153018,
-0.01154737,
0.024037654,
0.02000039,
-0.02618909,
0.016188895,
-0.01662715,
0.015870163,
0.035405736,
-0.023240825,
-0.018539539,
0.042417824,
0.01859266,
0.02365252,
-0.00958186,
-0.051448546,
0.036733784,
0.0054549538,
-0.013180868,
0.0073374603,
0.018393453,
0.0151662985,
-0.026109407,
-0.027968673,
-0.0001720236,
-0.003522645,
-0.004050544,
0.00062999234,
0.028340526,
-0.018991074,
-0.0063547054,
-0.014183544,
0.003519325,
-0.009136965,
-0.002677675,
-0.009176806,
-0.009794348,
-0.0009462336,
-0.015524872,
0.019548854,
-0.0038679373,
-0.013539441,
0.016507626,
-0.011985625,
0.0056442004,
0.017782552,
0.01860594,
-0.00037268322,
0.02982794,
0.027543698,
0.017570063,
0.01834033,
-0.00760307,
-0.019283244,
0.033333983,
-0.00091137236,
-0.029642012,
-0.0035857274,
0.017012283,
-0.0298545,
0.0022128585,
0.0008416499,
-0.013718727,
0.0076628323,
0.012755893,
0.0129551,
0.003067789,
-0.038114954,
-0.0026029723,
0.01012636,
0.012038748,
0.019203562,
0.018260648,
-0.026029725,
-0.0041501475,
0.010571255,
0.011348163,
0.029084232,
-0.0072245765,
0.0055113956,
0.012450442,
0.004638205,
0.0030877097,
-0.02055817,
0.0005727203,
-0.007795637,
-0.006713278,
-0.0005042429,
-0.005610999,
-0.028499892,
0.0059031695,
-0.0038081752,
-0.016666992,
-0.0046050036,
0.01636154,
0.019841025,
0.029163916,
-0.012503564,
-0.026972638,
0.008612386,
0.012802375,
-0.0017214811,
-0.015365506,
-0.015139737,
0.0048872135,
-0.009827549,
0.015936567,
-0.010604456,
0.02927016,
0.004734488,
0.004558522,
-0.000027235343,
0.013785129,
-0.00072793587,
-0.032165304,
0.0108899865,
0.022404155,
-0.008851434,
-0.023479873,
-0.020611292,
0.001349628,
-0.013579282,
-0.010657579,
-0.008545984,
-0.023519715,
-0.007383942,
-0.003549206,
0.01185282,
0.008605746,
0.0015181239,
0.026414858,
-0.022032302,
-0.01717165,
-0.03208562,
0.01630842,
0.0064011873,
-0.01806144,
0.0018625861,
-0.019376207,
-0.031395033,
-0.029349841,
0.016202176,
-0.01040525,
-0.020438645,
0.016733395,
-0.010963029,
0.0031491318,
0.036069762,
-0.020903463,
0.020332402,
-0.01549831,
-0.005770365,
-0.017782552,
-0.030332597,
-0.0038480167,
-0.013599203,
-0.023559557,
-0.012815655,
0.025790676,
-0.00038513367,
0.015670957,
-0.012822296,
-0.013758568,
0.003210554,
0.003325098,
0.016547468,
-0.008745191,
0.0048872135,
0.026295334,
0.014316348,
-0.0019870906,
0.0112552,
0.0035658067,
0.021580767,
0.03235123,
0.019203562,
-0.0031939533,
-0.015538151,
-0.0016168974,
-0.03208562,
0.014329629,
-0.025870359,
0.008300295,
-0.009415855,
0.018712183,
-0.024861043,
-0.04146163,
-0.021301877,
0.020093353,
0.019084038,
-0.01409058,
0.03739781,
0.001520614,
0.0038314161,
-0.0002869827,
-0.0035956877,
0.020890182,
0.007715954,
-0.033041812,
0.024024373,
0.013559361,
0.013639044,
0.010624377,
-0.032563716,
0.004880573,
0.008107728,
-0.011295041,
0.018911391,
0.018446576,
0.010949749,
0.006597074,
-0.008486222,
0.029934183,
-0.01691932,
-0.013851532,
0.0038646173,
0.014608518,
-0.01828721,
0.015657676,
0.0051594633,
0.02730465,
-0.006806242,
-0.025259458,
0.026135968,
-0.022364315,
-0.024768079,
-0.020478487,
-0.0026942757,
0.0062717027,
-0.034210496,
0.0021647168,
-0.014568677,
0.043320898,
0.024422787,
0.003801535,
0.007948362,
0.009800988,
-0.018818429,
0.0096283415,
-0.004561842,
0.0066634766,
-0.019323086,
-0.007828838,
-0.0044057965,
0.012589887,
-0.013260551,
0.0063447454,
-0.010478292,
0.015976407,
0.0018758666,
0.016666992,
0.005866648,
0.00076570216,
0.012616448,
-0.014834287,
-0.02282913,
0.017503662,
0.015299103,
-0.0026378336,
-0.01719821,
-0.011069273,
-0.01039861,
-0.017649747,
-0.007217936,
-0.0033699197,
-0.0005511396,
0.004020663,
-0.014674921,
0.004243111,
0.0032620158,
0.021607326,
0.01883171,
-0.018752025,
0.00787532,
-0.006504111,
-0.003721852,
0.007895241,
-0.0133335935,
0.044914555,
0.010378689,
0.0006411978,
0.014024178,
-0.008472941,
-0.007012089,
-0.008087807,
-0.02648126,
0.0028885026,
0.0057205632,
0.015338944,
-0.0013961096,
0.0016119173,
0.0030860496,
0.04252407,
0.011175517,
0.0033649395,
-0.03436986,
-0.008207331,
0.019070758,
0.053892154,
-0.0027639982,
-0.007629631,
0.009615062,
-0.0046149637,
-0.0070585706,
-0.011866101,
-0.001606107,
0.008937757,
0.015153018,
-0.015790481,
0.02927016,
-0.0067996015,
-0.0074503445,
-0.0019107278,
0.008519422,
0.017317735,
-0.039203953,
-0.009156886,
0.014170263,
-0.012603167,
-0.003326758,
0.015445189,
0.016773235,
0.024303263,
-0.014874128,
0.024927445,
0.03346679,
-0.027729625,
-0.019070758,
-0.03298869,
0.009661543,
-0.012543405,
0.008711989,
-0.007994844,
0.024183739,
0.0071448935,
-0.019522293,
0.013081265,
-0.010690779,
0.021182353,
-0.0029399644,
-0.0010848485,
0.0033848602,
-0.0042032693,
-0.021262035,
0.016109211,
0.027251527,
0.013001582,
0.013386715,
0.01124856,
-0.0067365193,
0.0059031695,
-0.014130422,
-0.014276507,
-0.0016476085,
0.011959065,
0.0025116692,
-0.013546081,
-0.021926058,
-0.011866101,
-0.011646974,
-0.0053155087,
-0.0007366511,
-0.005398512,
-0.018844988,
-0.02818116,
-0.008333496,
-0.010856786,
-0.015737358,
0.026786711,
-0.05070484,
-0.01609593,
-0.011686815,
0.0054151122,
0.009973634,
0.00076238206,
-0.012569967,
-0.04510048,
0.0090772025,
-0.0077292346,
-0.001296506,
-0.040452316,
-0.034821395,
0.0019787902,
0.010465012,
-0.006228541,
0.013473039,
-0.010690779,
0.0010865086,
-0.0014533816,
0.010577896,
-0.002933324,
0.008990879,
-0.007271058,
-0.0040704645,
0.011102474,
-0.001550495,
0.02029256,
-0.005428393,
-0.0034828037,
-0.003325098,
-0.025020408,
-0.019402768,
0.026082845,
0.00703865,
-0.02055817,
-0.01069742,
0.009827549,
-0.0095885005,
0.01043181,
-0.02249712,
0.030332597,
-0.0078354785,
0.003602328,
0.013094545,
0.034768276,
0.020930024,
0.034316737,
-0.006172099,
0.013346874,
0.01436947,
-0.009475617,
0.018074721,
-0.020903463,
-0.0018526257,
-0.016972443,
-0.006646876,
-0.05832783,
-0.006142218,
-0.01154073,
0.025710993,
-0.022523679,
-0.016653711,
-0.013034782,
0.004123586,
0.0020402125,
0.008466301,
-0.005687362,
-0.026946077,
0.023413472,
0.0014251606,
-0.0044489577,
-0.010996231,
0.026043005,
-0.017663026,
-0.025219616,
-0.013174227,
0.00033906705,
0.026799992,
0.008851434,
-0.0015031834,
0.0035425657,
-0.027278088,
0.004452278,
-0.040292952,
-0.011288401,
0.00647423,
0.021062829,
0.012895338,
0.010106439,
0.024489189,
0.025033688,
-0.0018908072,
-0.027782746,
0.00086074055,
-0.013014862,
-0.0022493799,
-0.031979375,
0.0074769054,
0.02277601,
-0.010086518,
0.0046050036,
-0.002365584,
0.010783743,
0.019323086,
0.015737358,
-0.021527644,
0.006002773,
-0.048075307,
-0.021992462,
0.01548503,
-0.0008283694,
0.015299103,
-0.026122687,
-0.0036786906,
-0.00507314,
0.0013396676,
-0.009243208,
0.0062650624,
0.020598011,
0.004113626,
0.030491963,
0.0029964063,
-0.0034794835,
-0.038088392,
-0.0054018316,
-0.036733784,
-0.000026496096,
0.019243402,
-0.012324277,
0.019854305,
-0.0060392944,
-0.0023141222,
-0.013486319,
-0.0055080755,
-0.017370857,
0.016839638,
0.008333496,
-0.027012479,
0.02083706,
-0.011215358,
-0.021195633,
0.00337988,
0.028765501,
0.009050641,
-0.00012844706,
0.017118528,
-0.028871745,
-0.025272738,
0.017609905,
0.0022194989,
0.015936567,
0.0108302245,
0.029243598,
0.005800246,
-0.004276312,
-0.023599397,
0.005239146,
0.011427846,
0.0017563424,
0.017915357,
-0.018141124,
0.007935082,
-0.053387497,
0.01602953,
0.007443704,
-0.018393453,
-0.021514364,
0.003516005,
0.014767884,
0.004880573,
-0.025963321,
0.01806144,
-0.006019374,
0.035379175,
-0.010896627,
0.020730816,
-0.007862039,
-0.00080595864,
-0.009781067,
0.014608518,
0.0048872135,
0.022138545,
-0.014329629,
-0.00036106282,
-0.005468234,
-0.0010806983,
0.002138156,
0.026082845,
0.024316544,
0.016839638,
0.00930297,
-0.0047809696,
0.016574029,
0.011666894,
-0.011593851,
-0.014223385,
-0.006537312,
0.028951429,
-0.027756186,
-0.024263421,
-0.0049635763,
0.0114411265,
-0.00028262503,
0.0071980157,
-0.013838251,
-0.00985411,
0.002342343,
0.00034798984,
0.010451731,
0.019761343,
-0.0074769054,
-0.014714763,
0.003067789,
-0.0349542,
-0.0069722477,
-0.020730816,
-0.017782552,
-0.02419702,
-0.025525067,
-0.01351952,
-0.011793058,
0.030677889,
0.0050233384,
0.018805148,
0.008539343,
0.032537155,
-0.024701677,
0.0015944866,
0.020983145,
0.00034819735,
-0.0074835457,
0.033307422,
-0.021886216,
-0.017277893,
0.0055910787,
-0.018393453,
-0.0070718513,
-0.042178776,
0.0041866684,
-0.0076229908,
-0.002963205,
-0.0016708493,
-0.007961643,
0.010212682,
0.016295139,
-0.01915044,
-0.03357303,
0.02253696,
0.0020817139,
-0.007689393,
0.020943303,
0.0053619905,
0.034449544,
-0.012384039,
0.017649747,
-0.0066601564,
-0.026507821,
-0.020226158,
-0.012291077,
0.009170165,
-0.021740131,
0.01464836,
0.0002871902,
-0.011188798,
0.0024618674,
0.012330918,
0.002418706,
0.0057272036,
0.020677695,
-0.00062999234,
0.0000489458,
0.015670957,
0.005182704,
-0.010544694,
-0.011666894,
0.018499697,
-0.029217036,
0.0063480656,
-0.02281585,
0.026972638,
0.016215457,
-0.02956233,
-0.02058473,
-0.00927641,
-0.035591662,
0.014542116,
-0.005823487,
-0.014382751,
0.005820167,
0.04106322,
-0.008619026,
0.028845184,
-0.0017945237,
0.018698905,
-0.0019738101,
0.024037654,
-0.026959358,
-0.0083069345,
0.01775599,
-0.0026942757,
-0.030093549,
-0.02309474,
0.003691971,
-0.013546081,
0.020903463,
0.030013865,
-0.014130422,
-0.010757182,
0.0014044099,
-0.0071913754,
0.007981563,
0.017795831,
0.02249712,
-0.039230514,
-0.018446576,
0.0089975195,
0.0145952385,
-0.01718493,
-0.021089388,
0.0121117905,
-0.025286017,
0.02588364,
-0.011613772,
-0.021713572,
0.015060055,
0.008804953,
0.0022427395,
0.04021327,
0.02423686,
0.029137354,
0.01549831,
0.006278343,
-0.01012636,
-0.010312286,
-0.051740717,
-0.013678886,
0.0073905825,
-0.011109115,
0.011142315,
0.012510204,
-0.0003208064,
-0.0047212075,
-0.012045388,
-0.035830714,
0.0014774525,
-0.016188895,
0.021992462,
0.037875906,
-0.016016249,
0.011613772,
-0.0022593401,
-0.013539441,
0.00647755,
-0.0078354785,
-0.013957775,
-0.050200183,
0.0076229908,
-0.00082753936,
0.0074171433,
0.00787532,
0.012510204,
-0.0066800774,
-0.0152459815,
0.014223385,
0.17976446,
-0.036096323,
-0.0034695233,
0.00760971,
0.015856883,
0.005149503,
0.013546081,
-0.0029466045,
0.00022327792,
0.026016444,
0.014409312,
-0.008824874,
0.008579184,
0.01297502,
0.019867586,
-0.030837255,
-0.008864715,
-0.038805537,
0.0024651876,
0.031129425,
0.008858074,
0.0057006422,
-0.018034881,
-0.02054489,
0.03548542,
-0.00031188357,
-0.016069371,
0.010305646,
0.019814463,
0.0034064408,
-0.007848758,
-0.0014176903,
0.031634085,
-0.00393766,
-0.00675644,
0.016680272,
0.019389488,
0.00031043103,
0.008472941,
0.013180868,
-0.0009869051,
-0.00046896664,
0.011175517,
-0.020385524,
0.011474327,
0.012702771,
-0.021753412,
0.0152459815,
-0.007955003,
0.0013380075,
-0.024608715,
-0.018765306,
-0.006172099,
0.011434486,
-0.0067664003,
-0.0010358768,
-0.005126262,
-0.011381364,
-0.0027756186,
-0.011055993,
-0.023718921,
0.0021315156,
-0.0025747514,
-0.00039571655,
-0.009714665,
0.034608908,
-0.014316348,
-0.0035923675,
-0.013134386,
-0.0031441515,
0.0045485613,
-0.0010674179,
-0.0042198696,
0.0018742066,
-0.011055993,
-0.03803527,
0.013399996,
0.0005610999,
0.010073238,
0.009708025,
-0.027729625,
0.025578188,
-0.015352225,
-0.03012011,
-0.0127426125,
-0.026401578,
0.02225807,
-0.009840829,
-0.022324473,
-0.021567486,
-0.004674726,
-0.0051461826,
-0.0006046765,
-0.020053511,
0.0076761125,
0.018234087,
0.0019970508,
0.0127226915,
-0.001831045,
-0.0029731656,
-0.02085034,
0.07468937,
0.045498896,
0.007383942,
0.044117726,
0.0060724956,
-0.015073335,
0.028499892,
-0.0010010155,
0.025193054,
-0.004711247,
-0.01883171,
0.011959065,
-0.02139484,
-0.0019605297,
-0.008240532,
0.039921097,
0.0014965432,
0.034688592,
-0.008838153,
-0.017596625,
-0.02338691,
0.009183446,
0.024130616,
0.0022360994,
-0.014568677,
-0.0028835223,
0.008904556,
-0.026096126,
-0.006109017,
-0.0031956134,
-0.011055993,
-0.020013671,
0.025511786,
0.02617581,
-0.0038480167,
-0.008121008,
-0.0163217,
-0.040452316,
0.024369664,
0.0016376481,
-0.0027075561,
0.022483839,
-0.0009238228,
0.0067697205,
0.009794348,
-0.0051926645,
0.017689588,
-0.019084038,
-0.005667441,
0.01379841,
-0.021594048,
-0.0012740953,
-0.013957775,
-0.008838153,
-0.0057205632,
-0.013074624,
-0.035352614,
0.018539539,
0.019402768,
-0.016481064,
0.0009669843,
0.028818624,
-0.014528836,
0.0059330505,
0.018433295,
-0.16690896,
0.011573931,
0.02452903,
-0.021461243,
0.021554206,
0.032324668,
-0.0020700935,
0.019867586,
-0.020690974,
-0.004053864,
0.017091967,
0.01409058,
-0.019761343,
-0.012364119,
0.005202625,
-0.019933987,
-0.0024651876,
0.024582153,
0.035883833,
0.015803762,
0.021501083,
-0.017702868,
0.006866004,
-0.012158272,
0.02818116,
0.013745288,
0.0044489577,
0.027198406,
0.003152452,
-0.033971447,
-0.0009371033,
-0.020226158,
0.011925863,
-0.0031690525,
-0.021753412,
0.010657579,
0.007523387,
-0.021487802,
-0.019867586,
0.00085410033,
0.012563326,
0.017968478,
-0.021527644,
-0.0030179871,
0.00033138925,
-0.0015388746,
0.0010400269,
0.006397867,
0.005697322,
-0.038433686,
0.004106986,
0.008778391,
0.0054051518,
-0.005431713,
0.028765501,
0.02223151,
-0.0016135772,
0.0039542606,
0.011507529,
-0.034608908,
-0.017012283,
-0.044648945,
0.017530221,
-0.008379977,
-0.0026909555,
-0.0180216,
-0.011560651,
0.015564713,
-0.013599203,
-0.0010898287,
-0.0012068629,
0.017291173,
-0.0114809675,
0.007901881,
0.0056176395,
0.017370857,
-0.0037384527,
0.0010815284,
0.016507626,
-0.019920707,
-0.018247368,
0.01576392,
-0.015976407,
0.0035326055,
0.021235473,
0.000534124,
0.020212878,
0.01096967,
-0.007955003,
0.009229927,
0.026268773,
-0.028871745,
0.0025813917,
-0.013406636,
0.015976407,
0.0030860496,
-0.000070448754,
0.00845966,
0.036733784,
-0.0145952385,
0.01888483,
0.00930961,
-0.011202077,
-0.0121715525,
0.028606135,
0.019070758,
-0.009316251,
-0.0025149893,
0.019588696,
0.009761146,
-0.030916939,
-0.01746382,
0.004893854,
0.0034197215,
0.0038513367,
0.05099701,
0.0050831004,
-0.007762436,
0.008871355,
0.01915044,
0.03806183,
-0.014834287,
0.000901412,
-0.00015760184,
-0.013559361,
-0.027782746,
-0.11952424,
-0.018473135,
0.016149053,
-0.0071116923,
0.0055379565,
0.025471944,
-0.012231315,
-0.010411889,
-0.032776203,
0.03686659,
-0.030863816,
-0.032324668,
0.0068859244,
-0.006138898,
-0.0038114954,
-0.009190086,
0.000267062,
-0.017118528,
-0.0014716423,
0.01520614,
0.0054516336,
-0.031899694,
-0.0058732885,
0.012589887,
-0.012364119,
0.03152784,
-0.0133933555,
-0.0044688787,
0.008605746,
0.012337558,
0.012809015,
-0.025432102,
-0.0052192253,
-0.034316737,
0.0071448935,
-0.0139444955,
-0.0326434,
-0.00016725094,
0.026680468,
0.00563424,
0.0015031834,
0.02616253,
0.0032022537,
0.021315157,
-0.0014218405,
-0.01944261,
-0.013957775,
0.03439642,
0.010551334,
-0.0064941505,
-0.001352948,
-0.013678886,
-0.00817413,
-0.004528641,
-0.008545984,
0.022908814,
0.0013637384,
-0.004083745,
-0.005687362,
0.042125657,
-0.018951233,
0.020956583,
-0.0049370155,
0.00845302,
0.005946331,
0.009701384,
-0.034582347,
-0.0071183327,
0.029163916,
-0.0076960335,
-0.0103388475,
0.019362928,
-0.010564615,
-0.0057637244,
-0.029588891,
0.004578443,
-0.0242103,
0.019323086,
0.017012283,
-0.029934183,
0.0168662,
-0.0041335467,
0.0044389977,
-0.008419819,
0.015591274,
-0.004678046,
-0.011932503,
-0.0018459855,
0.013931215,
-0.009515458,
0.0055611976,
0.021461243,
0.016202176,
-0.03099662,
0.008891276,
0.00064700795,
0.005853368,
-0.017145088,
0.031448156,
-0.014249946,
-0.027517136,
0.006291623,
-0.04839404,
0.0067199185,
0.022165107,
-0.018512977,
-0.029721696,
-0.013479679,
0.022643205,
-0.015458469,
-0.0010242563,
0.005976212,
0.013479679,
-0.007901881,
-0.021753412,
-0.022988496,
-0.011474327,
-0.02844677,
-0.00282044,
0.008067886,
0.03612288,
-0.00731754,
-0.0114012845,
0.0027540377,
0.0219659,
0.013453118,
-0.008340136,
0.0066867173,
0.008499502,
0.018260648,
-0.024927445,
0.00090805226,
0.021368278,
-0.008579184,
-0.0023921449,
0.003549206,
-0.028845184,
-0.036149442,
0.0083467765,
0.011872741,
0.022749448,
0.043825556,
-0.008260453,
0.002056813,
0.018088002,
0.018512977,
-0.020119915,
0.0067830007,
-0.007928441,
-0.011069273,
0.012609808,
-0.01717165,
0.018406734,
0.008194051,
0.023333788,
-0.027676502,
-0.011009511,
-0.021753412,
0.013061344,
0.019243402,
-0.014794446,
-0.010186122,
0.039469562,
0.03070445,
0.02002695,
0.009229927,
-0.0038413764,
-0.0039443,
-0.023200983,
0.030199792,
-0.008340136,
-0.0051760636,
-0.017025564,
-0.017012283,
0.0065505924,
-0.003605648,
0.024303263,
-0.016069371,
0.02705232,
-0.004900494,
-0.0020070113,
0.026813272,
0.010876706,
-0.004332754,
-0.0051395423,
0.03017323,
0.011952424,
0.021846376,
-0.034847956,
0.023147862,
0.025325859,
0.0024967287,
0.025219616,
0.0026129328,
0.0054815146,
0.010411889,
-0.015153018,
0.007490186,
0.012603167,
0.00844638,
0.022656484,
0.04172724,
-0.008200691,
-0.0048340918,
-0.00021228004,
-0.011959065,
-0.028260844,
0.016680272,
-0.016507626,
-0.0242103,
-0.017052125,
0.00760307,
0.026932796,
-0.0035027245,
-0.0041899886,
-0.008891276,
-0.0030478681,
0.015577993,
0.0030877097,
-0.009243208,
-0.010637658,
-0.0020385524,
-0.0011338203,
-0.0065539125,
0.017902076,
-0.03266996,
0.039575804,
-0.0030013865,
0.029084232,
-0.010232603,
0.025232896,
-0.008811593,
0.008101088,
0.0030196472,
0.025471944,
0.011434486,
-0.0034728432,
-0.005292268,
0.010750541,
0.004004062,
-0.00023012568,
0.044330213,
0.018220806,
0.004050544,
0.0011778118,
-0.03182001,
0.0051594633,
0.0033450187,
0.020876901,
-0.009800988,
-0.04478175,
0.0051661036,
-0.0015579653,
-0.0048241313,
-0.0058400873,
-0.002053493,
0.021886216,
-0.013034782,
0.0208105,
-0.022311192,
0.0069191256,
0.025020408,
0.0036454895,
0.011793058,
0.021368278,
-0.027809307,
-0.0006212771,
0.009057282,
-0.005033299,
0.0012574947,
-0.022988496,
-0.0022427395,
-0.0014293108,
-0.036972832,
-0.027570259,
-0.0056475205,
-0.022855692,
-0.011321602,
-0.058168463,
0.03128879,
0.031209107,
-0.0017098607,
0.0014907329,
-0.021301877,
-0.032563716,
-0.02474152,
-0.009688104,
-0.0036222485,
-0.029509207,
-0.003575767
] |
Placebo-controlled trials are used extensively in the development of new pharmaceuticals. They are sometimes challenged as unethical in settings in which patients could be treated with an existing therapy (1-7). The issues of when placebo controls are ethically acceptable and when they are scientifically necessary are important and worthy of discussion. The Ethics of Placebo Controls The Declaration of Helsinki The Declaration of Helsinki (8) is an international document that describes ethical principles for clinical investigation. Those who contend that placebo controls are unethical whenever known effective therapy exists for a condition usually cite the following sentence in the Declaration as support for that position: In any medical study, every patientincluding | [
-0.023281414,
-0.013612335,
0.028359031,
-0.023308422,
-0.036596656,
0.023605518,
-0.0018484012,
0.005158643,
-0.02295731,
-0.029709462,
-0.0013073852,
-0.010452328,
0.01912209,
0.019446192,
-0.013895925,
0.0018315208,
0.04310573,
-0.015678493,
-0.007582665,
0.0037575716,
-0.030384677,
0.034084857,
-0.014706183,
-0.0022805387,
-0.03435494,
0.008622496,
0.022322608,
-0.036272552,
0.011991819,
-0.02779185,
0.0057899687,
0.007521895,
-0.03030365,
-0.006053303,
-0.0029068007,
-0.017731147,
-0.0034773573,
-0.01067515,
0.013004641,
0.025104495,
0.017190974,
0.027521765,
-0.00016532218,
-0.017312514,
0.009905404,
0.015691997,
0.018716961,
-0.008338906,
-0.01959474,
0.0335987,
0.027332705,
0.012815582,
-0.02442928,
-0.005675182,
0.0025776334,
-0.033247586,
-0.010398312,
0.020634571,
0.032761432,
-0.011006005,
0.007987794,
-0.02684655,
-0.01765012,
0.0026384026,
0.0014956013,
0.0047535137,
-0.002604642,
0.014314558,
0.01033079,
-0.002061094,
-0.001571563,
-0.004098555,
-0.011404382,
0.017947216,
0.03918948,
-0.021566369,
-0.0059115076,
-0.0026637232,
0.021431325,
0.015678493,
-0.0061849696,
-0.015651485,
-0.026968088,
0.028602108,
0.03340964,
0.0032849212,
0.0008402207,
0.023970133,
0.0031616944,
-0.0053983442,
-0.0042808633,
-0.004101931,
0.0013799707,
0.016718324,
-0.016839864,
0.0235515,
-0.007839247,
0.03184314,
0.0077312123,
-0.013828404,
0.012221392,
0.018865507,
-0.022876285,
-0.009959422,
-0.036650673,
0.008460444,
0.0022298975,
-0.015219347,
0.0047872746,
-0.0069277063,
-0.01833884,
0.022511669,
0.002113423,
-0.022916798,
0.02530706,
-0.010121473,
-0.0074003567,
0.009588053,
-0.008183606,
0.009567797,
0.009243694,
-0.013011394,
0.025455607,
-0.013403018,
0.026684498,
0.007130271,
-0.010695406,
0.001705762,
0.0010263268,
0.006870313,
0.006293004,
0.0058102254,
0.0057595843,
0.0054253526,
-0.026036292,
0.03051972,
-0.0096758315,
0.000897192,
-0.03008758,
-0.025442103,
0.012221392,
0.023632526,
-0.011215322,
-0.010141729,
-0.018190293,
0.02433475,
0.0018602174,
0.014139003,
-0.0037069304,
-0.005644798,
0.001613764,
0.00093770487,
0.009777114,
-0.006745398,
-0.011046518,
-0.013828404,
0.0074273655,
0.018095763,
-0.0101484815,
0.0027717578,
-0.010006687,
-0.018514397,
-0.013153189,
-0.0064010383,
0.02220107,
0.0175826,
0.0064854403,
0.021985002,
0.008960104,
0.007555656,
-0.026900567,
0.05887875,
-0.028926212,
0.009088394,
-0.023537995,
-0.0030739165,
-0.0069040735,
0.036380585,
-0.024604836,
0.00044184385,
-0.023537995,
0.014260542,
0.026441421,
0.03727187,
0.016974906,
0.015354389,
-0.000040803032,
-0.014760201,
0.019176107,
-0.015827041,
-0.0121606225,
0.013963447,
0.0036866742,
-0.015124816,
-0.6356744,
-0.03357169,
0.01900055,
-0.01221464,
0.028521083,
0.018987047,
0.035084173,
-0.009122155,
-0.024820905,
0.049290698,
-0.0033440024,
0.03143801,
0.02973647,
-0.020364486,
-0.031816132,
-0.022552183,
0.015489433,
-0.03049271,
0.044753253,
-0.010310533,
0.0019412432,
0.020175425,
-0.02220107,
-0.0044159065,
0.0009756857,
0.016731828,
-0.007852751,
0.0023210517,
-0.008798052,
0.0128020765,
-0.004858172,
0.022457652,
-0.00041272517,
0.039486576,
0.045860603,
-0.0072923223,
-0.0014128875,
0.00046421034,
0.011195065,
0.03319357,
-0.024645349,
-0.013288232,
0.027265184,
-0.006367278,
-0.021255769,
0.006404415,
0.019446192,
0.0033591948,
-0.0073125786,
0.018500892,
0.00078789156,
-0.024348253,
-0.029196298,
0.014868235,
0.01755559,
0.013855413,
0.029574418,
-0.00010729589,
0.00040639503,
0.0007718552,
0.0023463722,
0.002020581,
-0.009621814,
-0.02876416,
0.0024459665,
0.030816814,
-0.0076636905,
0.0032849212,
0.014395584,
0.014625157,
0.015381399,
0.029061254,
0.0039128712,
-0.03338263,
0.03127596,
-0.002601266,
-0.003239344,
0.005749456,
-0.018068755,
0.017744651,
-0.0009284207,
-0.006053303,
-0.01748807,
0.010513098,
0.028656125,
-0.009466515,
0.006772407,
0.015030286,
0.01997286,
0.012140366,
0.009621814,
0.013058659,
-0.012957376,
-0.022741241,
-0.026036292,
0.0335987,
0.029628435,
-0.03130297,
0.025523128,
-0.0044361628,
-0.008500957,
-0.027359713,
-0.016731828,
0.02116124,
-0.014733192,
0.0049189413,
-0.0029321213,
0.023956629,
0.04850745,
-0.015300373,
0.014436097,
0.006370654,
-0.011633955,
0.0058102254,
0.016974906,
-0.025239538,
-0.025442103,
0.006323389,
-0.014030969,
-0.044321116,
0.020837136,
0.0031194934,
0.02333543,
-0.0018062002,
0.021876967,
0.007981041,
-0.0260633,
-0.0285751,
0.005607661,
-0.03184314,
-0.007116766,
-0.009534036,
0.014949261,
0.007521895,
-0.004442915,
0.010506346,
0.023321927,
-0.018662943,
0.02170141,
-0.015475929,
-0.025172016,
-0.0043787695,
0.008858821,
0.016596785,
-0.0020155169,
-0.042565554,
-0.025158511,
-0.00035174482,
0.0021235512,
0.021458333,
0.008190358,
-0.039324522,
-0.01187028,
0.01651576,
0.01736653,
0.0015031975,
-0.027332705,
-0.024753382,
-0.013990455,
-0.011424638,
-0.013369258,
0.035192207,
-0.00042960557,
-0.021188248,
0.004577958,
-0.022619704,
0.0069108256,
0.0064415513,
-0.013423275,
-0.037812043,
0.0050742407,
-0.008399675,
-0.032329295,
0.05255874,
-0.005611037,
0.006340269,
-0.015178834,
-0.0310869,
-0.014057977,
0.004047914,
-0.011039766,
-0.021215256,
-0.012221392,
0.0062389867,
0.017069437,
-0.020134913,
0.013706865,
0.0002734621,
0.0050708647,
0.013180197,
0.007150527,
0.004885181,
-0.012268657,
0.023713551,
0.005243045,
0.007272066,
0.006647492,
0.018784482,
0.009844635,
0.028278006,
0.01658328,
0.0036461612,
0.019729784,
-0.025172016,
0.031654082,
-0.004989839,
-0.006363902,
-0.0051383865,
0.016178152,
0.023348935,
-0.009432754,
-0.0054321047,
-0.030060573,
-0.006103944,
-0.0078257425,
0.0009739977,
0.006877065,
0.0019952604,
-0.010803441,
0.012930368,
0.024294237,
-0.022538677,
0.022511669,
0.00011942866,
0.007542152,
-0.013949943,
0.014544132,
0.0136596,
0.024091672,
-0.008764291,
-0.007602921,
-0.013666352,
-0.010810193,
-0.004439539,
0.005124882,
0.01824431,
0.008804804,
-0.016151143,
0.03686674,
-0.0026704755,
0.009709592,
0.0028426552,
0.0042403503,
0.0100742085,
-0.027845867,
-0.003774452,
0.018797986,
0.0072045443,
-0.030573737,
0.015705502,
-0.0054253526,
0.016151143,
-0.027818859,
-0.018001232,
0.016745333,
-0.018703457,
0.009621814,
-0.0061984737,
0.046562828,
0.008838565,
0.013794643,
0.0117554935,
-0.005219412,
0.014665671,
0.025523128,
-0.025847232,
-0.016056614,
0.018068755,
-0.007886511,
-0.006363902,
-0.018865507,
-0.0068905693,
0.014449602,
0.012896607,
0.037406914,
0.0005313098,
0.020161921,
-0.006380782,
0.032167245,
0.013308488,
-0.030843822,
-0.02025645,
0.0035212464,
0.037568964,
0.018109268,
0.0023446842,
-0.026076805,
0.002241714,
-0.018906021,
0.0035144943,
-0.022592695,
-0.015138321,
0.0037406913,
-0.0072180484,
-0.013868917,
-0.010722415,
0.011971562,
0.008656257,
0.007542152,
-0.019851321,
0.008406427,
-0.009324719,
-0.0024138938,
-0.016421229,
0.009547541,
0.0069040735,
-0.009223437,
-0.020864144,
-0.011985066,
-0.021647394,
0.029223306,
-0.009155916,
0.013308488,
-0.0132814795,
0.036596656,
0.005621165,
-0.0010963804,
0.038082127,
0.009162668,
-0.03827119,
-0.00064483035,
-0.009945917,
-0.011066774,
0.016164647,
0.08151196,
-0.019459696,
0.026698003,
0.025860736,
0.011768998,
0.01814978,
-0.023159875,
-0.0155299455,
0.020621067,
-0.006117448,
-0.013976951,
-0.0032494722,
0.005715695,
0.010013439,
0.0014753449,
0.015327381,
0.0120795965,
0.0016551209,
-0.009723096,
0.002965882,
-0.00006150787,
-0.014665671,
0.025644667,
0.005705567,
0.025131503,
-0.015813535,
0.019351663,
0.015827041,
-0.014544132,
-0.0005498782,
0.014341568,
-0.005688687,
0.01067515,
-0.0016289563,
-0.012714299,
0.014625157,
-0.0016416166,
0.013963447,
0.012039084,
0.014881739,
0.034516994,
0.016191656,
0.006421295,
0.0019176106,
-0.009311215,
-0.022916798,
0.01689388,
0.004760266,
0.0027312448,
-0.020904656,
0.0058068493,
-0.02779185,
-0.0020475895,
-0.029034246,
0.0342199,
-0.016421229,
0.01952722,
-0.004091803,
-0.018392857,
0.006880441,
-0.022741241,
-0.032275278,
0.0130451545,
-0.015813535,
-0.01293712,
-0.026779028,
-0.011890537,
-0.006505697,
-0.010641389,
-0.0005566304,
-0.0064888163,
-0.0015563706,
-0.013760882,
0.00439565,
0.023713551,
-0.01356507,
0.0056785583,
-0.002466223,
0.019743288,
0.029817495,
0.008048563,
-0.019986365,
-0.016772341,
-0.023956629,
-0.00026818697,
0.0175826,
0.002381821,
0.0006334361,
-0.008122837,
0.020594059,
0.007062749,
-0.0029051127,
-0.007508391,
-0.0074408697,
-0.019743288,
0.011282844,
-0.0083861705,
0.0144901145,
0.0013554941,
-0.009007368,
-0.021849958,
0.012471221,
-0.007947281,
-0.008926342,
0.0057764645,
0.004311248,
-0.002469599,
-0.0030941728,
0.01900055,
-0.022754747,
0.018784482,
-0.032194253,
-0.004405778,
-0.0016390845,
0.028548092,
0.029250314,
0.008156598,
0.05231566,
0.007981041,
0.0014103554,
-0.027292192,
-0.00034499267,
0.026373899,
-0.0001120435,
-0.01651576,
0.0009942541,
-0.00898036,
0.01566499,
-0.03262639,
-0.001217919,
-0.013801395,
0.04310573,
-0.01158669,
0.0043517607,
-0.011087031,
-0.00709651,
0.001034767,
0.008892582,
-0.0062052263,
-0.0014584644,
0.032167245,
0.022687225,
-0.005165395,
-0.011451647,
0.024037655,
-0.030978866,
-0.011654211,
0.020391494,
-0.022997824,
-0.0005013472,
0.016178152,
0.009182924,
-0.010229507,
0.024942443,
-0.0051788995,
-0.03303152,
-0.011451647,
-0.011033013,
0.03249135,
0.020594059,
0.009817626,
-0.022579191,
-0.029844504,
0.0053206943,
0.0074813827,
0.009182924,
0.00044944,
-0.00042411944,
-0.032194253,
0.020269955,
-0.01708294,
0.01139763,
0.030627754,
-0.019419184,
-0.007981041,
0.02153936,
-0.0034452847,
-0.016137639,
-0.0030891087,
-0.029142281,
-0.016313195,
0.011748741,
-0.005931764,
-0.0004975491,
-0.031248951,
-0.00278695,
-0.0056853103,
0.0019243628,
-0.0032444082,
-0.014044473,
0.013234215,
-0.038865376,
-0.022741241,
0.023092354,
0.004405778,
-0.024510305,
-0.0107966885,
-0.021579873,
-0.002023957,
0.03241032,
0.019338159,
-0.0018602174,
0.0029895145,
-0.004044538,
-0.017596103,
0.016029606,
-0.029493393,
0.0034672292,
-0.012234896,
-0.017825676,
-0.00052624574,
-0.0046589836,
0.003504366,
0.0069074496,
-0.02018893,
0.018419866,
-0.0025658172,
0.0155299455,
-0.028899204,
-0.017731147,
0.015273364,
-0.025117999,
0.0020931666,
0.0034520368,
0.01708294,
0.038109135,
-0.0006072715,
-0.01777166,
0.008663009,
-0.0016205161,
-0.0036191526,
0.016191656,
0.008858821,
-0.0046961205,
-0.025334068,
0.00028211327,
0.027481252,
-0.005209284,
-0.025644667,
0.016853368,
0.027926894,
0.013132933,
-0.02122876,
-0.0065765944,
-0.02750826,
0.022646712,
0.0019378671,
-0.009115403,
-0.018960038,
-0.037325885,
-0.0061647133,
-0.003014835,
-0.007886511,
0.02663048,
-0.0090276245,
0.010661645,
-0.0045171888,
-0.0145711405,
-0.024928939,
0.018919526,
-0.00027578312,
0.0046994966,
-0.010459081,
-0.020931667,
-0.0016787534,
-0.005222788,
0.016151143,
-0.0028983606,
-0.018919526,
0.028223988,
0.012383443,
0.008109332,
0.044915304,
-0.030195616,
-0.0002968836,
-0.020715598,
0.0072045443,
-0.023321927,
-0.019837817,
-0.011168056,
0.01952722,
0.03856828,
-0.014706183,
-0.021242265,
-0.013740626,
-0.016974906,
-0.01881149,
-0.010749423,
0.010904723,
0.008750787,
0.008332154,
0.0028882322,
-0.015111312,
0.0037204348,
-0.004527317,
-0.0010980684,
-0.011465151,
0.0026856677,
-0.007636682,
-0.002432462,
-0.0011428015,
0.0043922737,
-0.010506346,
-0.0054456093,
-0.00061655574,
-0.005530011,
-0.003057036,
0.009905404,
-0.043159746,
-0.0065765944,
-0.009020872,
0.003771076,
0.017690634,
-0.01987833,
0.025226034,
0.016812854,
0.021728419,
-0.0042876154,
-0.033490665,
0.017663626,
-0.016745333,
0.006154585,
0.029412366,
-0.025334068,
-0.006836552,
0.0023446842,
0.020107904,
0.012903359,
-0.01717747,
0.023375945,
-0.008014803,
0.016286187,
-0.026995096,
-0.026049796,
-0.020891152,
0.0008579451,
-0.016083622,
0.014220028,
0.013146437,
-0.015719006,
-0.0114381425,
-0.013369258,
0.0020948546,
0.020823631,
-0.02085064,
0.017447555,
-0.013267975,
-0.021985002,
-0.023416458,
0.010432072,
-0.015354389,
0.040404867,
0.016070118,
0.005286934,
-0.015827041,
-0.021876967,
-0.047130007,
-0.0047940267,
0.01736653,
0.013018146,
0.0064955684,
0.0050472324,
0.025577145,
0.0039331275,
-0.00269242,
0.00028000324,
-0.004355137,
0.005881123,
0.020175425,
-0.03068177,
-0.0054928744,
0.021714915,
-0.050668135,
0.0046994966,
0.023686543,
-0.016029606,
-0.014422593,
0.0048277876,
0.013841908,
0.0011714981,
-2.88483e-7,
0.0025928258,
-0.0028460314,
-0.015773023,
0.003181951,
-0.032194253,
0.028440056,
0.023416458,
0.0050674886,
-0.009068138,
-0.01940568,
-0.00913566,
-0.0024071415,
0.012849342,
-0.020634571,
-0.022336112,
0.000584061,
-0.022700729,
-0.0016804414,
-0.002469599,
0.0068939454,
0.007157279,
-0.014017464,
0.0092707025,
-0.012700794,
0.011924298,
0.035840414,
0.015935075,
0.009648823,
-0.014274046,
-0.011714981,
0.0069344584,
-0.014139003,
0.0012871287,
0.0013774387,
0.00405129,
0.028305015,
-0.017096445,
0.011633955,
0.012086349,
-0.020526538,
-0.0052768053,
-0.0061377045,
0.0025472487,
-0.0194732,
-0.017569095,
0.011613699,
-0.020107904,
0.032977503,
-0.019419184,
-0.019918844,
0.010789936,
0.04440214,
-0.009682584,
-0.018838499,
0.010884467,
0.18992448,
-0.014111994,
-0.008858821,
0.014584645,
0.0061647133,
-0.010087713,
0.029034246,
-0.0038926147,
-0.031221943,
0.015691997,
0.017069437,
-0.026184838,
-0.037298877,
0.0042538545,
-0.015003278,
-0.0036191526,
-0.023619022,
-0.03476007,
0.0077649727,
0.004456419,
-0.014139003,
0.011951306,
0.0065293293,
-0.0013521181,
0.01573251,
-0.005519883,
-0.005884499,
0.005614413,
0.01331524,
0.015300373,
-0.028899204,
-0.022876285,
-0.0021826327,
0.026130822,
-0.0040647946,
-0.0057764645,
-0.018852003,
0.015975587,
0.005030352,
-0.018325336,
0.009905404,
0.014611653,
-0.024172697,
-0.012369939,
0.018514397,
0.040269826,
0.00538484,
-0.0001713358,
0.011863528,
0.0023885733,
-0.057042167,
-0.0045982143,
0.045401458,
0.032950494,
0.002435838,
0.0022265215,
0.018392857,
0.00027937023,
0.019581236,
-0.0061849696,
-0.012423957,
-0.0226062,
-0.01409849,
0.007839247,
-0.014071481,
0.0051046256,
-0.01928414,
0.0051417626,
-0.0022602824,
0.005705567,
0.0017842557,
0.0072923223,
-0.011991819,
0.01912209,
0.008744035,
-0.025914753,
0.027373217,
0.02741373,
0.0077177077,
0.025455607,
-0.03538127,
0.01755559,
-0.017312514,
-0.002516864,
-0.031789124,
-0.039702643,
0.010229507,
0.022309104,
-0.039459568,
0.029277323,
-0.010735919,
0.017663626,
-0.01783918,
-0.016934393,
0.009810874,
-0.0038588538,
0.009095146,
0.014827722,
-0.020499527,
-0.008379418,
-0.009824378,
0.07135672,
-0.040647946,
0.02122876,
0.013301736,
0.005671806,
-0.0156109715,
-0.00022113293,
-0.009371985,
-0.003411524,
0.010418568,
-0.037974093,
0.003636033,
-0.016596785,
-0.012694042,
0.04637377,
-0.0012837526,
-0.033868786,
0.00629638,
-0.01814978,
0.0043517607,
-0.007420613,
0.012619769,
0.04785924,
0.010033695,
0.026954584,
-0.013403018,
0.00072079204,
0.001841649,
-0.011478655,
-0.014125498,
-0.029304333,
-0.0034841096,
0.028007919,
-0.015178834,
-0.010499594,
-0.0008659633,
-0.023875603,
-0.010911475,
0.006154585,
-0.003193767,
0.0031279337,
-0.020053886,
0.0116744675,
0.0044766758,
-0.022187566,
-0.008143093,
-0.0040310337,
-0.016070118,
-0.0089533515,
0.002472975,
-0.030546729,
-0.0061883456,
-0.032599382,
0.015813535,
0.006431423,
0.0035111182,
-0.004925694,
-0.0028460314,
0.034841094,
-0.042538546,
0.030708779,
0.028007919,
-0.002646843,
-0.008426684,
-0.005033728,
-0.17047828,
0.015462425,
0.014895244,
-0.033895794,
0.031789124,
0.014152507,
0.006056679,
0.0030756046,
-0.019810809,
-0.0060431743,
0.02044551,
-0.0070357407,
-0.029844504,
-0.027170653,
0.009837883,
-0.03187015,
-0.02182295,
0.033328615,
0.037298877,
0.013787891,
0.0058000972,
0.006070183,
0.0046961205,
-0.015286868,
0.005165395,
-0.0025253042,
-0.0028662877,
-0.010729167,
0.0035212464,
-0.012045836,
0.0007718552,
-0.005340951,
0.0380011,
0.029466383,
0.0022315856,
-0.0069884756,
0.02317338,
0.0027244927,
-0.013240967,
0.0016357084,
-0.0082308715,
0.00976361,
-0.008480701,
-0.006016166,
-0.0073058265,
0.042430513,
0.026252361,
-0.040701963,
0.0050134715,
0.0019496834,
0.0048750527,
-0.009601558,
0.0010474273,
0.013193701,
0.017879695,
0.020350982,
0.00530719,
0.010857457,
-0.024186203,
-0.010060704,
-0.01023626,
-0.04010777,
0.0010381431,
-0.0034942378,
-0.0058102254,
-0.00047476057,
-0.00076932315,
-0.0059520206,
-0.0035415029,
0.01259276,
-0.03132998,
-0.013511052,
-0.008014803,
-0.021066708,
0.022093035,
0.02056705,
0.014638661,
0.008399675,
-0.017163966,
0.045293424,
-0.01563798,
0.00021754584,
-0.0072112964,
-0.018419866,
0.006117448,
-0.0085482225,
-0.0029186169,
0.01221464,
-0.009453011,
-0.010587372,
0.02182295,
-0.024226716,
-0.010391559,
-0.011255834,
-0.011768998,
0.01604311,
0.000854569,
0.003544879,
-0.011877032,
-0.02665749,
-0.00009057377,
0.008622496,
-0.011714981,
0.009142412,
0.017893199,
0.008879078,
-0.018906021,
-0.006343645,
0.02615783,
0.022916798,
-0.042376496,
-0.013139685,
0.0108777145,
0.025401589,
0.0031279337,
0.027683817,
-0.0018180165,
-0.006461808,
-0.0042741112,
-0.011512416,
0.059526958,
-0.005654926,
0.002285603,
0.008372666,
-0.020013373,
-0.008156598,
-0.11754143,
-0.0012297353,
0.02719766,
-0.023321927,
0.013018146,
0.037001785,
-0.011127544,
0.007643434,
0.007184288,
0.01950021,
-0.01447661,
0.0028645997,
-0.00090647617,
-0.021471838,
0.024483297,
0.018365849,
0.004355137,
-0.020364486,
0.002599578,
0.038325205,
-0.014179516,
-0.015908066,
-0.012356435,
-0.03205921,
0.008602239,
0.000043783475,
-0.0020813504,
0.031383995,
0.0097568575,
0.00069082936,
0.002608018,
-0.008156598,
0.0033440024,
-0.015556954,
0.0003650381,
-0.0007718552,
-0.007089758,
-0.010161987,
0.030600745,
-0.017231487,
0.0009528972,
0.010904723,
0.03132998,
0.009925661,
0.02779185,
-0.017217983,
-0.030573737,
0.01259276,
-0.010830449,
0.0055941567,
-0.02916929,
-0.033220578,
0.0017808797,
0.008852069,
0.007488135,
-0.013700113,
0.0077312123,
-0.0012314235,
-0.0003103879,
-0.008413179,
-0.019932348,
0.005634669,
-0.022214575,
-0.0006684629,
-0.01168122,
-0.010337542,
-0.027899886,
-0.012126862,
0.0072923223,
-0.015962083,
-0.029223306,
0.0023615647,
-0.013706865,
0.022768252,
-0.029223306,
-0.025995778,
-0.018514397,
-0.029412366,
0.013585326,
-0.0044766758,
0.00064061023,
-0.0018348969,
0.009459763,
-0.0091896765,
0.029979547,
0.020648075,
-0.00017334036,
0.022187566,
0.009554293,
-0.03538127,
-0.0036191526,
0.026954584,
-0.014584645,
-0.016272683,
-0.014179516,
0.003198831,
0.014220028,
-0.0213503,
0.020215938,
0.014139003,
-0.016434735,
-0.018960038,
-0.049128644,
-0.0010398312,
0.007589417,
-0.013909429,
-0.011006005,
-0.004459795,
0.03432793,
-0.00038845965,
0.009426001,
-0.012829086,
-0.035192207,
0.01928414,
-0.011066774,
0.0070154844,
-0.031789124,
-0.013490796,
0.021579873,
0.004054666,
0.024253724,
-0.006100568,
-0.023754064,
-0.017731147,
0.004534069,
0.0021944488,
0.016596785,
0.0019648757,
-0.019554228,
-0.008217367,
-0.017528582,
-0.0014289238,
-0.004135692,
-0.013976951,
0.00060094136,
0.007981041,
-0.01808226,
-0.0001347265,
0.0046556075,
0.03824418,
0.01658328,
0.03918948,
-0.017690634,
-0.032923486,
0.01428755,
-0.03278844,
-0.0046522315,
0.0035617594,
-0.03527323,
0.020404998,
-0.004095179,
-0.0072045443,
0.02741373,
0.014044473,
-0.02681954,
-0.011937802,
-0.008777795,
0.000033285993,
-0.020499527,
0.010864209,
0.00810258,
-0.02025645,
0.038487256,
-0.00014464372,
0.0047940267,
0.01287635,
-0.006748774,
0.0030941728,
-0.007062749,
-0.008703521,
0.014746697,
0.026779028,
-0.022039019,
-0.0026687875,
-0.009669079,
-0.012504983,
0.010560363,
0.0010592436,
-0.00907489,
0.021431325,
0.019297646,
0.013868917,
0.027872877,
-0.011762246,
-0.04264658,
0.010857457,
0.024604836,
-0.00359552,
-0.043915987,
0.0107156625,
0.015178834,
-0.009750105,
0.004118812,
0.0014728127,
-0.012518487,
0.007873007,
0.0047906507,
0.007596169,
-0.010918227,
-0.007272066,
-0.0033946435,
0.022714233,
0.0062187305,
0.006016166,
0.03575939,
-0.022849277,
-0.019945852,
-0.009554293,
-0.05693413,
-0.026049796,
-0.0052362927,
0.010114721,
0.02895322,
0.0140849855,
0.0098919,
-0.020783119,
-0.0051383865,
0.0051080016,
-0.0077244597,
-0.007927025,
-0.010945235,
0.012302418,
-0.00090056803,
0.0031194934,
0.0136596,
-0.015989091,
0.0042538545,
-0.027427234,
0.019392176,
-0.01783918,
0.001709982,
0.020283459,
0.0008828436,
0.011687973,
-0.032113228,
0.0028848562,
0.008561727,
-0.04850745,
-0.012457717,
-0.016745333,
0.0030671642,
0.037947085,
0.0016770653,
-0.010020191,
0.019392176,
-0.010823697,
0.019135594,
-0.003777828,
0.041593246,
-0.02549612,
-0.016421229,
0.0317081,
-0.0062052263,
0.0555837,
-0.014679175,
-0.01337601,
0.008136341,
-0.013099171,
0.02170141,
-0.0019986364,
0.0015411783,
0.008744035,
-0.0010769679,
0.01639422,
-0.016758837,
-0.015097808,
-0.007467878,
0.011235578,
-0.020391494,
-0.02954741,
0.005607661,
0.0002749391,
0.017123453,
-0.012788572,
-0.01580003,
0.020540042,
0.0016264243,
-0.00762993,
-0.00020319752,
-0.00058659306,
-0.010479338,
-0.0044699237,
0.03243733,
-0.013416522,
-0.03008758,
-0.0064888163,
-0.019608244,
-0.004888557,
0.01843337,
-0.026441421
] |
In 30 patients with cancer of the large bowel, 24 (80%) had detectable levels of methane in their breath, compared with 25 (39%) of 64 patients with non-malignant large-bowel disease and 83 (40%) of 208 subjects without large-bowel disease. These findings suggest that there may be a difference in anaerobic intestinal flora between patients with cancer of the large bowel and those without the disease. This difference may antedate the development of the tumour or, alternatively, result from the tumour. | [
0.009163126,
-0.0077187247,
0.0132741155,
-0.019842548,
-0.030587327,
0.0035031638,
-0.03623422,
-0.02731945,
-0.024326075,
0.02429993,
0.008104335,
0.027946882,
-0.012568254,
0.019437332,
-0.008182763,
0.016836101,
0.051109593,
0.0048429933,
-0.010391848,
0.004859333,
0.0009697424,
0.02671816,
-0.019228186,
0.0053168354,
-0.0035391105,
0.007692582,
0.02143727,
-0.04067853,
0.0038234158,
-0.025816226,
0.020809839,
-0.00932652,
-0.04154125,
0.005225335,
-0.012561718,
0.0062710554,
0.020064764,
0.0075422595,
0.018796828,
-0.0077775465,
-0.001298164,
0.00016574262,
-0.0066926116,
0.017764177,
-0.019999405,
0.012424467,
0.012274145,
-0.025711654,
-0.011149995,
-0.0072481507,
0.02219542,
0.0077252607,
-0.013568224,
0.0030603665,
-0.0034312706,
0.0048462613,
0.005088084,
-0.00035068401,
-0.01977719,
-0.0052220672,
-0.009980096,
-0.0003323022,
-0.016679242,
0.012659755,
-0.0052580135,
0.007744868,
-0.008999732,
0.02048305,
0.009888595,
0.02645673,
0.018260894,
0.026326016,
0.0014729954,
0.010385312,
0.037593655,
-0.0030325896,
-0.01925433,
0.0005179585,
-0.0065553607,
0.0020554946,
0.023620212,
-0.019188972,
0.0017434122,
0.035240784,
0.01933276,
-0.00066868926,
-0.008306943,
-0.004937762,
0.005192656,
0.019594189,
0.012940791,
0.016234811,
0.030587327,
0.005271085,
0.0012859094,
0.02194706,
-0.022535278,
0.025698584,
0.041671965,
-0.041305963,
-0.015607379,
0.011182674,
-0.0035652535,
-0.0077187247,
-0.0009852649,
0.014104156,
0.010940852,
-0.0019019042,
0.021829417,
-0.027868453,
-0.011417962,
0.030613469,
0.00815662,
-0.016979888,
-0.0022630047,
0.010659814,
0.027476307,
0.0006527584,
-0.017568106,
-0.007025935,
0.018260894,
-0.02228692,
0.011692463,
-0.019934049,
0.0038364872,
-0.0041698106,
-0.028940316,
-0.009646772,
0.008444194,
-0.011248032,
0.026561303,
0.0023741124,
0.0383518,
0.02239149,
0.00040399126,
0.015215234,
-0.014365586,
-0.03406435,
-0.011195745,
-0.016365526,
-0.014849232,
0.023829358,
-0.012627075,
-0.00483319,
-0.044547696,
-0.0009419655,
0.034561064,
-0.0016184159,
-0.0047514928,
-0.022221562,
0.010385312,
-0.018757613,
-0.022496063,
-0.012921184,
0.006359288,
-0.012542111,
0.02002555,
0.030901043,
-0.02490122,
-0.021607202,
-0.01014349,
-0.014234871,
0.015934167,
-0.0046501886,
0.00652595,
0.014862304,
0.011287246,
-0.0021682363,
-0.021267341,
-0.010888565,
0.007398473,
0.04572413,
-0.015725022,
0.02758088,
0.0043593477,
0.009842845,
-0.024783578,
0.01388194,
-0.00461751,
-0.030770328,
-0.008973589,
0.055632334,
0.019058257,
-0.012921184,
-0.02185556,
-0.0060161613,
0.02836517,
0.0072024004,
0.027946882,
-0.023803214,
-0.005591337,
0.036966223,
0.010849351,
-0.013999584,
-0.64960164,
-0.02063991,
-0.0001279578,
-0.014300229,
0.024169216,
-0.0024427378,
0.0057972134,
-0.0115421405,
-0.016339384,
-0.0003825458,
0.009019339,
0.008117406,
-0.0016625323,
-0.0050259945,
0.006601111,
-0.012202252,
-0.0036632898,
-0.0061926264,
0.024535218,
-0.02410386,
-0.019319687,
0.006385431,
0.0040194886,
0.016169455,
-0.015803453,
0.016247883,
0.014182585,
-0.02334571,
0.023319568,
0.03547607,
-0.024260717,
0.020417694,
0.0014656427,
0.010012775,
0.041175246,
-0.012261073,
-0.0026192032,
-0.0009926176,
-0.002305487,
0.0045652236,
0.017058317,
-0.023201926,
0.029593892,
0.0029884733,
-0.03955438,
0.019960191,
0.018966757,
0.012600932,
0.0026731233,
-0.020548409,
-0.0018675915,
0.028652743,
-0.00046036215,
-0.002418229,
0.036652505,
-0.00481685,
0.031423904,
-0.04389412,
-0.0073788655,
0.0091827335,
0.004058703,
0.025450224,
-0.0037417188,
-0.02290128,
-0.016901458,
0.021188913,
-0.022966638,
-0.015110662,
0.011437569,
0.006336413,
0.025881583,
0.022888208,
0.0031665727,
0.0014591069,
0.039711237,
0.047841717,
0.0058560353,
0.02228692,
-0.016953744,
0.002674757,
0.014796946,
0.0065128785,
-0.028522028,
0.004836458,
0.044861414,
0.010568313,
-0.0095029855,
-0.0012401593,
-0.006856005,
0.013947298,
0.017502747,
0.019947119,
0.00083085767,
-0.024260717,
0.0009787291,
0.008352693,
-0.02836517,
0.009150055,
0.017136745,
-0.032129765,
-0.021515701,
-0.012149965,
0.03565907,
0.011509462,
0.019920977,
-0.019659547,
-0.037149224,
0.0011249665,
-0.0031159206,
-0.0040946496,
0.0017875286,
0.015855737,
0.013555152,
-0.009097769,
0.0021666023,
-0.014692374,
0.020143192,
0.019842548,
-0.016613886,
-0.024914293,
0.009241556,
0.014548588,
-0.0006654214,
-0.014653159,
0.024496004,
0.00980363,
0.019149758,
-0.014365586,
-0.0014460355,
-0.027894596,
-0.01614331,
0.00030575073,
0.021502629,
0.0002173138,
0.0016829565,
0.009163126,
0.044233978,
-0.01751582,
-0.024875078,
-0.019711832,
-0.021999346,
-0.0035227712,
0.0166531,
0.002991741,
0.0034443422,
0.0053691217,
-0.033855204,
0.012032323,
-0.03147619,
0.024443718,
0.017738035,
-0.00027511438,
-0.016457027,
0.022862066,
0.017189031,
0.009470306,
0.01101928,
-0.024234574,
-0.003656754,
0.00042768338,
0.010548706,
0.02048305,
0.02507115,
-0.031240901,
-0.0040423637,
-0.023750927,
0.008790588,
0.004836458,
0.017764177,
-0.025803154,
-0.0064801998,
-0.020940553,
0.015934167,
-0.005643623,
0.0006029233,
-0.0093526635,
-0.033985917,
-0.0017058316,
0.0030897774,
-0.0045913667,
0.012234931,
0.022574492,
0.0009868988,
0.008208906,
0.039502095,
-0.008287336,
0.01579038,
-0.0077317962,
-0.0074899737,
0.026286801,
-0.020430766,
0.006150144,
-0.0046469206,
0.007071685,
0.017306676,
-0.010875494,
-0.0056959093,
-0.005829892,
0.009646772,
-0.00062661537,
0.0057710703,
-0.0029067763,
0.023554856,
-0.01101928,
0.028391313,
0.007816761,
-0.010999673,
0.008784053,
0.04737114,
-0.015555093,
-0.008705623,
-0.003627343,
0.0064115743,
0.021737916,
-0.018979829,
0.025345651,
-0.019385045,
-0.020757552,
0.01700603,
0.0034378064,
0.018456968,
-0.0010154927,
-0.005117495,
0.013725082,
-0.0020162798,
-0.004983512,
0.0057351235,
0.016247883,
-0.017921036,
0.0052024596,
0.013555152,
0.023371855,
0.009699058,
0.0009150055,
0.022613708,
0.0033724487,
0.013306794,
0.00035517736,
0.005548855,
0.00015767505,
-0.016992958,
0.032260478,
0.007333115,
0.0025244348,
0.010855886,
0.0017711892,
0.010699028,
0.007627224,
-0.0054736934,
0.008182763,
0.0070063276,
-0.004326669,
-0.015110662,
-0.0004558688,
-0.018692255,
-0.022443777,
0.008058584,
0.014862304,
0.02116277,
0.004976976,
0.019202044,
0.008143549,
-0.00061967113,
0.0009868988,
-0.00578741,
-0.0006151778,
0.0010489884,
0.0014680936,
-0.0010179436,
0.009960488,
-0.012326431,
0.007973619,
-0.0015718488,
-0.031110186,
0.014966875,
-0.0022597369,
0.008705623,
0.003150233,
0.012254538,
0.019345831,
-0.009882059,
-0.032887913,
0.036208075,
0.02454829,
-0.011718606,
-0.004738421,
-0.0121695725,
0.014823089,
-0.01596031,
0.004692671,
-0.020626837,
0.026143014,
-0.012698969,
0.027241021,
0.009784023,
0.008967054,
-0.01725439,
-0.021149699,
0.025554797,
0.012189181,
-0.011241496,
-0.012195716,
-0.0061632157,
0.009764416,
0.023528712,
-0.003578325,
-0.04031253,
-0.006548825,
-0.010986602,
-0.0062906626,
-0.011293782,
-0.00056248327,
-0.0165616,
0.016522385,
-0.008143549,
0.013319866,
0.010653278,
-0.0034116632,
0.041175246,
-0.0038266836,
-0.016548527,
-0.029018745,
0.012411396,
-0.0031959834,
0.03419506,
0.0010955557,
0.007790618,
-0.0055848015,
0.018979829,
-0.008489944,
0.0054442827,
-0.03840409,
0.01240486,
-0.007254686,
-0.009012804,
0.01240486,
0.026221443,
0.012914649,
-0.005307032,
0.0048887436,
-0.017633462,
-0.016666172,
-0.031528477,
0.020757552,
-0.005075013,
0.00070136803,
0.014195656,
0.021450343,
0.017790321,
-0.011810106,
0.005212263,
0.028809601,
0.01847004,
0.0014174415,
-0.015751166,
0.010640207,
0.01118921,
0.036338788,
-0.0010212115,
-0.0019934047,
0.015293663,
0.0046697957,
0.0029999109,
-0.0017385104,
0.023045067,
0.01509759,
0.002566917,
0.004326669,
0.0019198776,
-0.025005793,
-0.032992482,
0.041227534,
0.012718576,
-0.0073788655,
0.029437033,
-0.0019509224,
-0.003552182,
-0.01405187,
0.038822375,
0.011555213,
-0.0026110336,
0.021463415,
-0.009823238,
0.0026322748,
-0.007137043,
-0.02410386,
0.010855886,
0.0055978727,
-0.010006239,
-0.0036796292,
-0.029724607,
-0.031606905,
-0.019881763,
0.008084727,
-0.0042580436,
-0.033149343,
-0.009908202,
0.0010694127,
0.027345592,
0.018326253,
0.012875434,
-0.023920858,
-0.023698643,
0.001803868,
0.0029116783,
0.0042122933,
0.0011298684,
-0.012123823,
-0.012502897,
0.039946526,
0.0065292176,
-0.011555213,
-0.022848994,
0.008176228,
-0.0033757167,
-0.012444074,
0.00054696086,
0.0074376874,
-0.0042776507,
0.0016421081,
0.008032441,
0.0065651643,
0.0070912926,
-0.009248091,
0.008444194,
-0.012555182,
-0.029907608,
-0.0055521224,
-0.023228068,
-0.020679124,
0.0056044087,
0.010803601,
-0.00923502,
-0.017790321,
0.024012359,
-0.016731529,
0.00026959984,
0.001379044,
0.0042711147,
0.014627016,
-0.015110662,
0.012313359,
0.01162057,
0.0026061316,
-0.0068102553,
-0.0001318384,
0.009091233,
0.004343008,
-0.017816463,
-0.002333264,
-0.008882089,
-0.0030162502,
-0.051292595,
0.0073069725,
0.015973382,
0.017528892,
0.0060357684,
-0.050090015,
-0.0404171,
-0.023110425,
0.01097353,
0.015032233,
-0.035711356,
-0.020430766,
-0.026404444,
0.019045185,
0.0017058316,
-0.034665637,
0.031606905,
-0.017672677,
-0.019842548,
0.0045488845,
-0.007934405,
-0.015372092,
-0.0012368914,
0.0049475655,
-0.026443658,
0.0075422595,
-0.0042874543,
-0.01288197,
0.013855797,
-0.0075618667,
0.041305963,
0.02003862,
0.008084727,
-0.0037907371,
0.03079647,
0.0011257835,
-0.002418229,
0.000305138,
-0.018809898,
0.016901458,
-0.0068298625,
-0.0011315023,
-0.001565313,
0.014078013,
-0.006777576,
-0.0042809187,
0.008901697,
0.020535337,
-0.027633166,
0.0003476204,
-0.031188617,
-0.021960132,
-0.025920799,
-0.019568047,
0.0023937197,
0.028077597,
-0.030587327,
-0.021188913,
0.033724487,
0.010071596,
0.00006857435,
-0.0106009925,
0.009319984,
0.0005400166,
0.008195835,
0.013672796,
-0.00012520053,
0.0021241198,
-0.013999584,
0.0059344643,
-0.032757197,
-0.013012685,
-0.00037539733,
0.001777725,
0.0041763466,
-0.03644336,
0.0039672023,
-0.004633849,
-0.024260717,
-0.01977719,
-0.0075945454,
-0.032652624,
-0.019724904,
0.006705683,
0.008457265,
-0.018260894,
-0.018195538,
0.00694097,
0.0052416744,
0.032077476,
-0.0070128636,
-0.023567926,
0.02037848,
-0.0021845757,
0.021032054,
-0.01466623,
0.030247467,
-0.008339621,
-0.021894773,
-0.019764118,
-0.0036436825,
-0.0044443123,
-0.019907905,
0.041175246,
0.006414842,
-0.00075079466,
-0.004640385,
0.0260123,
0.025620153,
-0.01066635,
-0.030927185,
0.008659873,
0.001245061,
-0.0009918006,
-0.029620035,
-0.016457027,
-0.039606664,
0.016979888,
0.009699058,
-0.0029035085,
-0.030064465,
-0.014940732,
-0.028757315,
0.0017973322,
-0.0096337,
0.005150174,
0.0049181543,
0.0012761059,
-0.018234752,
-0.005146906,
-0.036208075,
0.012783933,
0.019123614,
0.012751255,
-0.009078162,
0.015123733,
-0.009208877,
0.023228068,
-0.026443658,
-0.002416595,
-0.026587445,
0.03215591,
-0.0071631856,
-0.004006417,
-0.016626956,
0.017816463,
0.022914352,
-0.01028074,
-0.0029312854,
-0.0029459908,
-0.02022162,
0.014940732,
0.038038086,
0.03521464,
-0.0006548008,
0.010012775,
-0.032992482,
-0.005169781,
-0.028835744,
-0.0017515819,
0.008627195,
-0.022103919,
0.0029280176,
-0.02219542,
0.020300051,
0.010483349,
-0.00081288436,
0.0037580582,
-0.015934167,
0.03252191,
-0.02645673,
0.009241556,
0.0031453313,
-0.006467128,
-0.0022450313,
0.029463178,
-0.012718576,
-0.013228365,
0.0012001278,
0.0037711298,
-0.028495885,
-0.014953804,
-0.007816761,
-0.0014452185,
0.00024611197,
-0.0093526635,
0.005088084,
0.031606905,
0.011502926,
-0.014117228,
-0.02810374,
0.01760732,
-0.031528477,
0.013411366,
0.007320044,
0.025541725,
-0.007215472,
-0.0053103,
-0.0066370578,
-0.018326253,
0.014064942,
-0.020417694,
-0.016600814,
0.011032352,
0.011509462,
-0.009424557,
-0.0043593477,
-0.0013945664,
-0.022744423,
-0.003735183,
0.01777725,
0.009071626,
0.009306913,
0.009607557,
-0.018862184,
0.0038920413,
-0.009927809,
-0.033018626,
0.014274086,
-0.0014934196,
-0.020849053,
0.0076795104,
-0.017620392,
0.029123317,
-0.010378776,
-0.017241318,
-0.027685452,
-0.0056076767,
-0.011032352,
-0.009457235,
-0.008810196,
0.02359407,
-0.009045483,
-0.00030983557,
-0.02125427,
0.029620035,
-0.031528477,
0.012921184,
-0.016025668,
-0.005512908,
0.027476307,
-0.004741689,
-0.011842785,
-0.0068298625,
-0.011470247,
-0.012914649,
-0.00094033155,
0.004026024,
-0.009895131,
0.009300377,
-0.016470099,
-0.017816463,
-0.021620272,
-0.014417872,
0.007097828,
0.01109771,
-0.0131107215,
-0.010091203,
-0.020169334,
0.0076991175,
0.006307002,
0.012862363,
0.000087671004,
0.0052612815,
0.007764475,
0.0015024063,
-0.002146995,
-0.01847004,
0.0051240306,
-0.020352336,
-0.0005861754,
-0.004006417,
0.0061141974,
0.015842667,
0.0038234158,
-0.012417932,
-0.018927542,
-0.009261163,
-0.011110781,
-0.020652981,
0.018757613,
-0.01751582,
-0.037672084,
0.0001502202,
-0.01405187,
-0.0044410443,
0.0063331453,
-0.032260478,
-0.016443957,
0.0054214075,
0.01951576,
0.010842815,
-0.0055031045,
-0.026326016,
0.015764238,
-0.028051455,
-0.004372419,
-0.023110425,
-0.017528892,
-0.028417457,
0.007097828,
0.0006466311,
-0.011045423,
-0.008104335,
0.023737857,
0.007189329,
-0.025018865,
0.0043560797,
0.18090966,
-0.0006429547,
-0.004222097,
0.03756751,
-0.0062351087,
-0.0058919815,
0.018966757,
-0.0068494696,
-0.022234634,
0.018744541,
0.013215293,
-0.0070455424,
-0.017568106,
0.0014680936,
0.013646653,
0.014234871,
-0.03218205,
-0.022757493,
0.006973649,
-0.022574492,
-0.01831318,
-0.019097472,
-0.001749948,
0.010346098,
-0.0058429637,
-0.0061958944,
-0.00035027554,
0.0029884733,
0.019528832,
0.0027107038,
-0.0050782803,
-0.005117495,
-0.018770684,
0.0132610435,
-0.013025757,
0.0029035085,
-0.0007871498,
-0.007829833,
-0.003392056,
0.006856005,
-0.00145829,
0.012437539,
-0.009248091,
-0.000033444678,
-0.027790023,
0.01630017,
-0.009725201,
-0.0061403406,
0.010705564,
-0.0018055019,
-0.02914946,
-0.008065119,
0.00073282135,
0.012646683,
-0.004395294,
-0.010365705,
0.023790143,
-0.0113787465,
0.00867948,
0.053018034,
0.006601111,
0.013842726,
-0.023306496,
0.04886129,
-0.036338788,
0.018483112,
-0.03184219,
0.0060030897,
-0.0032646088,
-0.00546389,
0.006842934,
-0.040730815,
-0.019620333,
-0.0011118951,
-0.016195597,
-0.017947178,
0.023136567,
0.014483229,
0.00013204264,
0.028522028,
-0.008084727,
-0.016901458,
-0.02419536,
-0.00087334006,
-0.039502095,
-0.037515227,
-0.027397878,
0.017136745,
-0.0038397552,
-0.013934227,
-0.011280711,
-0.015019162,
0.011306854,
-0.010163097,
0.016862243,
-0.0052351383,
0.0037874691,
-0.01140489,
-0.011836249,
0.0010563411,
-0.03296634,
0.061279226,
-0.023045067,
-0.000015305408,
-0.013594368,
-0.00087334006,
-0.020404622,
0.011339532,
0.025868513,
0.01245061,
0.008038977,
0.00042441548,
-0.0071174353,
-0.022234634,
0.020744482,
0.0213327,
0.008953982,
-0.00029594707,
0.008071655,
-0.022587564,
-0.005467158,
-0.013091114,
0.021868631,
0.015803453,
-0.009829774,
0.011045423,
-0.029829178,
-0.007607617,
-0.008751374,
-0.013398294,
-0.009208877,
-0.026169157,
-0.015829595,
-0.0019688958,
-0.0050292625,
0.020326193,
-0.009319984,
-0.017646534,
-0.0017532159,
-0.014600873,
-0.008908232,
0.007078221,
-0.010319955,
-0.010182704,
0.02836517,
-0.032704912,
0.034221206,
-0.015672738,
-0.011895072,
0.0006388699,
-0.028731173,
-0.0072416146,
-0.023450283,
0.008496479,
0.033933632,
-0.029044889,
-0.003630611,
-0.029280176,
0.011653248,
0.013319866,
-0.03615579,
-0.0027482843,
0.031450044,
-0.016169455,
0.0142218,
0.017450461,
-0.16355069,
0.026600517,
0.007176257,
-0.027999168,
0.028757315,
-0.0027221413,
-0.0055619264,
0.0017205371,
-0.0016298535,
0.012744719,
0.030665755,
-0.010150026,
-0.022966638,
0.018836042,
-0.013829654,
0.007797154,
0.0043691513,
0.027502451,
0.012777398,
0.011509462,
0.029044889,
-0.014417872,
0.008215442,
-0.022848994,
-0.011921214,
0.015280591,
-0.0010555242,
0.03879623,
-0.038822375,
-0.010326491,
-0.019907905,
0.009914738,
0.028469741,
-0.008829803,
0.020443836,
0.0032221265,
-0.012149965,
-0.044704553,
-0.018195538,
-0.013352544,
0.012254538,
0.029855322,
0.017123675,
-0.009685987,
-0.006277591,
0.004633849,
0.013672796,
-0.005068477,
0.0028561242,
0.007901726,
0.024025429,
-0.0066926116,
0.010823208,
0.007888654,
-0.024025429,
0.011515997,
0.0166531,
0.015659666,
-0.015881881,
-0.029567748,
0.015189091,
-0.04954101,
-0.013058435,
0.030770328,
-0.015947238,
-0.011274175,
0.00017503565,
0.0010571581,
-0.009084697,
-0.00081778615,
-0.019005971,
-0.00641811,
0.019358901,
-0.0109212445,
0.033358485,
-0.014404801,
0.005486765,
-0.002624105,
-0.0112284245,
0.0050521377,
-0.018966757,
0.030038323,
-0.047554143,
-0.006705683,
-0.022182347,
0.01620867,
0.00028614345,
0.0132675795,
-0.020300051,
-0.0109147085,
0.014470158,
-0.021005912,
-0.01968569,
-0.0051861205,
-0.006738362,
0.039580524,
0.025175722,
-0.0107121,
0.007875583,
-0.011966964,
0.010594456,
-0.011934286,
-0.030038323,
0.039789665,
0.01796025,
0.0050194585,
-0.012071537,
-0.030561183,
0.027868453,
-0.0016314875,
-0.022260776,
-0.007973619,
-0.0015538754,
0.020247765,
-0.010685957,
0.018287038,
-0.013078042,
-0.0156204505,
0.0151498765,
0.0013847628,
0.040547814,
-0.008967054,
0.013319866,
0.017594248,
0.02420843,
-0.00023896349,
-0.13238822,
-0.031371616,
0.01414337,
0.03688779,
0.0039312555,
0.0069344346,
-0.0191759,
0.005166513,
-0.015921095,
0.02576394,
0.016940674,
-0.030482754,
0.011463712,
0.017724963,
0.029410891,
-0.00784944,
0.0026224712,
-0.014953804,
0.005865839,
0.009993167,
0.009404949,
0.012993078,
0.004104453,
-0.027162591,
0.009313448,
-0.018012537,
-0.019345831,
0.020849053,
0.010084667,
0.007842904,
0.029986037,
0.0021437271,
0.00014542052,
-0.01822168,
0.008947447,
0.022234634,
0.007627224,
-0.0238555,
0.010849351,
-0.007960548,
0.0021159502,
0.019999405,
0.017136745,
0.02419536,
0.03497935,
-0.029881464,
-0.039711237,
0.006856005,
-0.014169513,
-0.034116633,
-0.019633403,
0.009927809,
-0.022090847,
-0.00082146254,
0.0069082915,
-0.017332818,
0.012267609,
0.029410891,
-0.0054606223,
-0.004179614,
-0.0043364726,
-0.00008113525,
-0.020077834,
0.04967173,
-0.0013357446,
-0.0075814743,
-0.011149995,
-0.009261163,
-0.0014966875,
-0.018391611,
-0.014117228,
0.024273789,
-0.010398384,
-0.013855797,
-0.027528593,
-0.005382193,
0.0023937197,
-0.008699087,
-0.004107721,
-0.015332878,
0.005372389,
-0.012614004,
0.006914827,
-0.01343751,
0.00009190903,
0.017202104,
-0.0062939306,
-0.008535694,
0.005391997,
-0.0031159206,
-0.02263985,
0.045567274,
-0.0031387955,
-0.034221206,
-0.006444253,
0.033672202,
-0.016587742,
-0.024417575,
0.0028397848,
-0.013476724,
-0.0030260538,
-0.021881703,
-0.03495321,
0.006231841,
0.02159413,
-0.00975788,
0.026404444,
-0.009117376,
0.0400511,
0.01257479,
0.017894894,
0.04101839,
-0.007980155,
0.043998692,
-0.013019221,
-0.01262054,
-0.016430885,
-0.0054246755,
0.009372271,
0.012274145,
0.0053233714,
0.016496241,
0.026613588,
0.0020571284,
-0.00008087995,
0.021293486,
-0.015921095,
0.0057972134,
-0.016182525,
0.026064584,
-0.03019518,
-0.013725082,
0.007470366,
-0.020391552,
-0.0021420931,
-0.011359139,
-0.023580998,
-0.014927661,
-0.0191759,
0.0090389475,
-0.008816731,
0.027711594,
0.01569888,
-0.012672826,
0.014091085,
-0.000318618,
0.014470158,
-0.001589822,
-0.010633671,
0.026692018,
-0.0046861353,
0.0011494757,
0.025620153,
-0.0051567093,
0.0068037193,
-0.037279937,
-0.01639167,
0.016600814,
-0.0190844,
0.00037927795,
-0.023005852,
-0.014195656,
0.03165919,
0.011025816,
0.013542081,
0.011123853,
-0.008855946,
-0.0072808294,
-0.0014468525,
-0.02237842,
0.014692374,
-0.051057305,
-0.021554915,
-0.031162472,
0.0049704406,
0.016117169,
0.017541962,
0.010679421,
-0.017973322,
0.011398354,
0.013999584,
0.037018508,
0.021672558,
0.006019429,
-0.022679064,
0.010882029,
0.027946882,
0.006816791,
-0.012332967,
0.0067448975,
0.0061109294,
-0.0032531712,
-0.00583316,
0.016443957,
0.018626897,
-0.017541962,
0.016901458,
0.030299753,
-0.0003751931,
0.006143608,
0.018352395,
0.00875791,
-0.0090389475,
0.008960518,
-0.029384747,
-0.010718635,
-0.002570185,
0.0045488845,
-0.021228127,
-0.040861532,
-0.02585544,
0.011202281,
0.023698643,
0.031685334,
-0.022090847,
0.0037743975,
-0.0024933899,
0.01166632,
-0.0115486765,
-0.006682808,
-0.0028283473,
0.019045185,
0.009535665,
0.0070063276,
0.010287276,
-0.013038828,
0.023437211,
-0.016705386,
0.012607468,
-0.0008251389,
0.0076402957,
-0.011555213,
-0.008640266,
0.013228365,
-0.05673034,
-0.020456908,
0.009476842,
-0.013764297,
0.020260835,
-0.005228603,
-0.0035456463,
0.06964499,
-0.003477021,
-0.011529069,
0.034744065,
0.005146906,
0.020169334,
0.027214877,
0.008306943,
0.019371973,
0.010790529,
0.021411128,
-0.009091233,
0.024430646,
-0.039528236,
-0.008228513,
0.01140489,
0.02073141,
-0.007352723,
0.031345475,
-0.007829833,
-0.0018218412,
-0.000044090804,
-0.0048266537,
0.0027907668,
-0.015372092,
0.008836338,
0.0117055345,
0.0034508777,
0.003526039,
-0.025123436,
0.008398443,
-0.0074442234,
-0.033802915,
-0.0031224561,
0.039057665,
-0.0004427973,
-0.0023920857,
-0.04180268,
0.009306913,
0.0137381535,
-0.017724963,
0.02611687,
-0.01526752,
-0.020391552,
-0.021411128,
-0.033907488,
0.0090258755,
-0.015228306,
-0.004026024
] |
Neurogenesis is known to take place in the adult brain. This work identifies T lymphocytes and microglia as being important to the maintenance of hippocampal neurogenesis and spatial learning abilities in adulthood. Hippocampal neurogenesis induced by an enriched environment was associated with the recruitment of T cells and the activation of microglia. In immune-deficient mice, hippocampal neurogenesis was markedly impaired and could not be enhanced by environmental enrichment, but was restored and boosted by T cells recognizing a specific CNS antigen. CNS-specific T cells were also found to be required for spatial learning and memory and for the expression of brain-derived | [
-0.019480115,
0.005257268,
0.015148283,
-0.03250186,
-0.027408678,
0.008243606,
0.0068456065,
0.010855832,
-0.019506369,
-0.023811946,
0.021619776,
0.005480423,
0.0020264438,
-0.003974127,
-0.011695945,
0.0057134232,
0.03785758,
0.02055651,
-0.00364924,
0.011243071,
-0.03882896,
0.020582763,
0.022971833,
-0.021803552,
0.0030454088,
0.00017321172,
0.0027746693,
-0.036098596,
-0.006963747,
-0.022368003,
0.012811719,
0.003383423,
-0.020530256,
-0.014281917,
0.0008827747,
-0.027382426,
0.0066552684,
-0.026384791,
0.028432567,
0.023260621,
0.003560634,
0.01568648,
-0.009628479,
0.0071475217,
0.014938255,
0.011584368,
-0.021330988,
0.0038527045,
0.0042465073,
0.024100734,
0.024113862,
0.018994424,
0.0023365635,
0.0036000144,
-0.013093945,
-0.03896023,
-0.0020264438,
0.019834537,
0.02529527,
-0.033053186,
0.0004495916,
-0.008565212,
-0.009254367,
0.015712734,
0.00366893,
0.011308705,
0.011275888,
0.010553917,
0.011984734,
-0.00926093,
0.018233072,
0.01625093,
-0.023930088,
-0.002681141,
0.0137831,
-0.012024114,
-0.01520079,
-0.008913071,
-0.0034785918,
0.014085015,
0.011118367,
-0.051404398,
-0.014846368,
0.036308624,
0.010908339,
0.017340453,
-0.0011165952,
0.00926093,
0.019138819,
0.010816452,
0.0033735777,
0.022184227,
0.033000678,
0.025347777,
0.014190029,
0.022079213,
-0.009956649,
0.013769973,
-0.011197127,
-0.0065896343,
-0.0312942,
0.020687778,
-0.014150649,
-0.027434932,
-0.036151104,
-0.016999157,
0.02108158,
0.0045845215,
0.030559102,
-0.00030765848,
-0.0061958316,
0.021357242,
-0.02541341,
-0.04678378,
0.0032800497,
0.019703269,
0.01799679,
0.0076594655,
0.0119191,
-0.006563381,
0.021698538,
0.007981071,
0.024021974,
-0.004210409,
-0.0076594655,
0.03570479,
0.002905937,
-0.002343127,
-0.029325185,
-0.001160898,
-0.018640002,
0.0072197192,
0.007390367,
0.008985269,
-0.037122484,
-0.004006944,
0.013408987,
-0.0005833205,
-0.016421579,
-0.024218876,
-0.001071472,
0.027907496,
-0.017904904,
0.003383423,
0.005267113,
0.030139046,
0.0144656915,
0.012778902,
0.01430817,
0.00093774305,
-0.013441804,
-0.028511327,
0.016080283,
-0.0010296304,
0.024100734,
0.005595282,
-0.019913297,
0.035232227,
-0.0114793535,
-0.01333679,
0.012207888,
-0.03599358,
0.013179269,
-0.00043236272,
0.023326255,
0.018745016,
0.0006641321,
0.0059858034,
0.032764398,
-0.021291608,
0.011892846,
0.023746312,
-0.02824879,
0.01063924,
-0.008808057,
0.023536284,
0.014544453,
0.012562311,
-0.029010143,
-0.018561242,
-0.008420818,
0.023221241,
0.0067077754,
-0.015279551,
-0.0067602824,
-0.0066027613,
0.02387758,
-0.016854763,
-0.012175072,
-0.013678086,
-0.016684115,
0.003773944,
-0.018167438,
-0.044053413,
-0.6468868,
-0.014150649,
0.04431595,
-0.011098677,
0.0037411272,
0.03142547,
-0.010901776,
0.0064747753,
-0.024901466,
0.02209234,
-0.009096846,
0.03126795,
0.00790231,
0.0031356553,
-0.017261691,
-0.033499498,
-0.007652902,
0.0042563523,
0.034392115,
-0.00087210926,
-0.015489579,
-0.019624509,
0.012371973,
0.021501636,
0.0021380214,
0.032029297,
0.021068452,
-0.016815381,
-0.016526593,
0.014898875,
-0.020438368,
0.018469354,
-0.01892879,
-0.012293212,
0.05229702,
0.011269325,
-0.027382426,
0.04053544,
-0.01463634,
0.027408678,
-0.0030093102,
-0.0064616487,
0.0035737609,
-0.007922001,
-0.011656565,
0.032869413,
-0.016684115,
0.021252228,
0.005004578,
-0.008932762,
0.013041438,
-0.008453635,
-0.019138819,
0.009759747,
0.007738226,
-0.007528198,
0.014990762,
0.012667325,
0.027854988,
-0.010068227,
-0.0043646484,
0.01386186,
-0.03210806,
-0.004006944,
-0.007633212,
0.015528959,
-0.02610913,
-0.0062056766,
0.0058709444,
-0.024205748,
0.0022627255,
0.008703043,
-0.017970538,
-0.01560772,
0.009589099,
0.020530256,
0.0015350108,
-0.00691124,
-0.011033043,
0.014793861,
-0.014938255,
-0.014531326,
-0.013015185,
0.007547888,
0.017156677,
-0.008565212,
-0.012739522,
0.015397692,
-0.013271157,
0.0015555213,
0.014833241,
-0.00574624,
-0.0006128557,
-0.060593132,
-0.011945353,
0.011590931,
0.0018984579,
0.018246198,
0.010803325,
-0.011078987,
-0.013402424,
0.010960846,
0.008860564,
0.0044270004,
0.010120734,
0.007600395,
-0.02022834,
0.014951382,
0.0625359,
-0.015082649,
-0.0046173385,
0.024428904,
-0.008132029,
0.0030142327,
-0.007423184,
-0.016841635,
0.023510031,
0.0071606487,
-0.0071606487,
-0.014505072,
0.016434707,
-0.0003593451,
0.00012552466,
-0.0063533527,
0.029613975,
0.010324198,
-0.00028386622,
0.007889184,
-0.021711664,
-0.015699606,
-0.0040725777,
-0.00126181,
0.017248565,
-0.0008991832,
0.02444203,
0.026292903,
0.016447833,
0.001071472,
0.016434707,
-0.03153048,
-0.019256959,
-0.007600395,
-0.0024612679,
-0.0051916344,
-0.017747382,
0.005447606,
-0.011840339,
-0.008840874,
-0.025833467,
-0.024035102,
-0.0017819579,
-0.014570706,
-0.030191552,
0.020018311,
0.028878877,
-0.00667824,
-0.025085242,
-0.009214987,
0.009274057,
-0.019860791,
-0.008191099,
0.01743234,
0.01739296,
0.015463325,
-0.026581693,
-0.013638706,
-0.005936578,
0.011289015,
0.01467572,
-0.037201244,
-0.013290847,
-0.008913071,
-0.020530256,
0.0059332964,
0.018075552,
0.007515071,
-0.017668622,
0.006839043,
0.007035944,
-0.005670761,
-0.013369607,
-0.010947719,
0.000066556786,
0.0016129508,
0.018915664,
0.0023250778,
0.032606877,
0.006819353,
0.01787865,
0.02253865,
0.007790733,
0.040194146,
-0.010002593,
-0.004390902,
-0.0013167782,
-0.03323696,
-0.005165381,
0.011728762,
0.013874987,
0.018141184,
-0.012004424,
-0.021619776,
0.007816987,
-0.020451495,
0.031477977,
-0.021974199,
-0.0051161554,
-0.007790733,
-0.001510398,
0.012614818,
-0.0009328205,
-0.0013791304,
0.00072484335,
-0.020359607,
0.011151184,
-0.00691124,
0.0024186058,
-0.0119191,
-0.0030404862,
-0.026240397,
0.0129758045,
0.005565747,
0.017458593,
-0.012509804,
-0.008854001,
0.04439471,
0.016040903,
-0.00066864444,
-0.009326564,
-0.02379882,
0.013769973,
0.0016629966,
0.0016236163,
0.02201358,
0.0034063947,
0.011768142,
-0.013166142,
-0.0034917186,
0.00023976852,
0.010914902,
0.034917187,
0.012811719,
-0.005450888,
-0.009444705,
-0.003211134,
0.00016757131,
0.01426879,
-0.013028312,
-0.009497212,
0.011695945,
-0.013678086,
-0.0128839165,
-0.012490114,
-0.006766846,
-0.010271691,
-0.0144656915,
0.006976874,
-0.004453254,
0.024389524,
0.03607234,
0.0017885213,
-0.009825381,
-0.0018475917,
-0.020910932,
-0.013395861,
0.0013733874,
0.03226558,
-0.0022939018,
-0.002513775,
-0.021212848,
-0.033053186,
-0.0067274654,
-0.014085015,
-0.032921918,
0.017064791,
0.0028107679,
0.00599893,
0.0069046766,
0.018377466,
0.0076397755,
-0.015187663,
-0.02026772,
0.016776001,
0.025977861,
0.0034063947,
-0.0020149578,
-0.00918217,
-0.017524227,
-0.008256733,
-0.0113677755,
0.0065075923,
0.0114005925,
-0.0021363804,
-0.0113940295,
-0.025584059,
-0.027277412,
0.02379882,
0.0010706515,
0.0128839165,
-0.020241467,
0.0011149544,
0.0036459581,
-0.019663889,
-0.0128970435,
0.014544453,
0.003964282,
-0.010685184,
-0.0051817894,
-0.026450425,
-0.0041710287,
0.005946423,
0.0028320989,
0.007757916,
-0.006530564,
0.008873691,
-0.012273522,
-0.0056740427,
0.016421579,
0.0038723948,
0.024901466,
-0.00663886,
-0.036597412,
0.0005738856,
-0.02861634,
0.046074934,
0.003583606,
-0.02213172,
0.019020678,
0.000011684613,
-0.012161945,
0.00013280592,
0.013888114,
0.026437297,
-0.01836434,
-0.0156471,
-0.007049071,
-0.0009106691,
-0.022000453,
0.021895438,
0.018679382,
-0.0023464088,
0.00021495072,
-0.011019916,
-0.007869494,
0.016592227,
0.010553917,
-0.0049422258,
0.036492396,
0.035652284,
-0.0055362117,
0.01840372,
0.028826369,
0.010993663,
-0.020293973,
0.0002393583,
0.013153016,
0.015817748,
0.001017324,
-0.010606424,
-0.02379882,
0.0128839165,
0.018272452,
0.021383494,
-0.010271691,
0.025150876,
0.017287945,
0.014846368,
-0.0041611837,
0.008781804,
0.007547888,
0.021357242,
0.01187972,
-0.014820114,
-0.008086085,
0.027960002,
-0.016080283,
-0.011695945,
-0.009333128,
0.020648396,
-0.009753184,
0.009109973,
0.0040627327,
-0.009838508,
0.0056116907,
-0.006035029,
-0.029561467,
-0.018298706,
-0.0144394385,
0.0014825037,
-0.015633974,
0.020083945,
0.007751353,
-0.018797522,
-0.015528959,
0.009418451,
-0.011295578,
-0.043790877,
0.0029289087,
0.014649467,
0.021921692,
0.03672868,
-0.016237805,
-0.0057429583,
0.030559102,
0.010435776,
-0.02533465,
-0.0114596635,
-0.011072423,
0.029824004,
0.017064791,
0.009083719,
-0.020320227,
0.010383269,
-0.014938255,
0.029613975,
-0.0015300881,
0.026082875,
0.0123851,
-0.006996564,
-0.008650536,
0.022683045,
0.018390594,
-0.0023053875,
-0.01828558,
-0.021856058,
-0.034234595,
-0.021225974,
-0.0069703106,
-0.013271157,
-0.014295043,
-0.0052441414,
0.008453635,
-0.005342592,
-0.009589099,
0.017091043,
-0.005080057,
0.01840372,
0.009641606,
0.0068456065,
0.019178199,
0.0129298605,
0.009621916,
0.013573072,
-0.014085015,
0.0054968316,
-0.017406086,
0.013717466,
0.0026548875,
-0.009149353,
-0.024980228,
0.009838508,
0.01382248,
-0.010376705,
0.0061662965,
-0.00914279,
0.024140116,
-0.0083420575,
-0.028485073,
-0.018062424,
-0.01877127,
0.008177972,
0.002733648,
-0.003276768,
-0.013093945,
-0.020097073,
-0.0054935496,
-0.021449128,
-0.01904693,
0.022276115,
-0.035100963,
-0.012398226,
0.019611383,
0.026161637,
0.0063631977,
-0.011991297,
0.0036525214,
-0.021554142,
0.013966874,
-0.0029666482,
-0.011965044,
0.02578096,
-0.0184431,
0.022669917,
0.014741354,
0.030112792,
0.0098844515,
-0.009379071,
0.022827439,
0.004528733,
0.003951155,
0.0032078524,
0.034602143,
-0.027093636,
0.013008621,
-0.005946423,
0.0024235283,
0.009608789,
-0.020543382,
0.013251466,
0.022761805,
0.0030700215,
-0.03153048,
0.0004754349,
-0.030007778,
-0.033867046,
0.01852186,
-0.008250169,
0.0046698456,
-0.012844536,
-0.0067930995,
0.043764625,
0.01114462,
0.019427607,
-0.003445775,
0.025439665,
-0.022184227,
0.017064791,
0.012660761,
-0.006012057,
-0.0057101413,
-0.02440265,
-0.0013036515,
-0.018981298,
0.03552102,
0.007967944,
-0.016736621,
0.0019805003,
0.0035803244,
-0.00621224,
0.008493015,
-0.014071888,
-0.01999206,
-0.041769356,
-0.033788286,
-0.021593524,
-0.018180566,
-0.010061663,
-0.009516902,
0.000012242243,
0.0008155001,
-0.014229409,
0.021252228,
-0.0027467748,
-0.020451495,
0.016762875,
-0.013290847,
0.02533465,
-0.020819044,
0.01999206,
0.037122484,
0.006668395,
-0.013612452,
-0.012614818,
0.016355945,
-0.0004282606,
0.05072181,
0.02436327,
-0.020346481,
-0.009077156,
0.0048043947,
0.004358085,
0.0040660147,
-0.009175607,
0.02257803,
0.008932762,
-0.015922762,
-0.012431043,
-0.013290847,
-0.04770265,
0.013146452,
0.0015153206,
-0.007186902,
0.0023972748,
-0.011558114,
-0.024835834,
0.029587721,
-0.009635043,
0.004515606,
-0.010146987,
-0.0030700215,
-0.00011044939,
-0.011551551,
-0.014216283,
0.008945888,
0.0014562501,
0.04329206,
-0.005982522,
-0.0056871697,
0.019322593,
-0.00555262,
-0.00026007398,
0.014951382,
0.01434755,
0.032659385,
-0.015817748,
-0.017156677,
0.012398226,
0.0074494374,
0.0070096906,
-0.018023044,
-0.0031225285,
0.005503395,
-0.004476226,
-0.009523465,
0.020451495,
0.005017705,
-0.012201325,
-0.0144263115,
-0.027933748,
-0.01248355,
-0.034365863,
-0.0026745778,
0.00531962,
-0.022433637,
0.020464621,
0.023667552,
0.017196057,
0.0099303955,
-0.015568339,
0.003286613,
-0.009805691,
0.038277637,
-0.03258062,
0.036203608,
0.012240705,
0.036754932,
-0.017419213,
-0.007915437,
-0.00017895468,
-0.01743234,
0.0036984652,
-0.03441837,
-0.03336823,
0.015542086,
-0.014360677,
0.011820649,
0.004472944,
-0.0016006446,
0.014124395,
-0.006130198,
0.020044565,
0.016447833,
-0.012437607,
0.024061354,
-0.01945386,
-0.025912227,
-0.00034765407,
-0.04232068,
-0.018259326,
0.00049594545,
0.013231776,
0.0043515214,
-0.017366705,
0.010882085,
-0.021751044,
-0.0058250003,
-0.012732959,
-0.002576127,
0.0061564515,
-0.004673127,
-0.01888941,
0.008210789,
0.0052014794,
-0.01061955,
-0.005375409,
0.026201017,
0.013021748,
0.009155916,
-0.008972142,
0.010389832,
0.0010419367,
-0.04024665,
-0.05565747,
0.0030683805,
-0.0039150566,
0.040404174,
-0.007350987,
-0.0059726764,
-0.0008003223,
-0.015056396,
-0.05954299,
-0.0075019444,
0.024743946,
-0.009451268,
0.0175111,
0.02347065,
-0.009904142,
-0.014806988,
0.00434824,
0.029403947,
0.010219184,
-0.005250705,
-0.0016236163,
-0.010875522,
0.01374372,
0.015844002,
-0.010652367,
-0.015266424,
0.032606877,
-0.0062713106,
-0.020687778,
-0.0010427572,
-0.023405015,
0.014006255,
-0.015568339,
0.019939551,
0.013638706,
-0.005204761,
0.02801251,
-0.014360677,
0.004843775,
0.0001523935,
-0.018023044,
-0.012181635,
-0.030034032,
0.0005291726,
-0.00025269017,
0.01739296,
-0.012339156,
-0.005214606,
0.03473341,
-0.023549411,
0.030532848,
0.023654426,
-0.00731817,
0.016565973,
0.009234677,
-0.015568339,
-0.025531553,
-0.003806761,
-0.0069046766,
-0.015030142,
-0.020005185,
-0.017563608,
0.011243071,
0.007685719,
0.021265354,
-0.035967328,
0.0020691059,
0.0037148737,
0.017550481,
-0.026004115,
0.018141184,
0.015581466,
-0.041086763,
-0.015699606,
-0.012102874,
-0.004994733,
-0.018193692,
-0.00025986886,
-0.021055326,
-0.011781269,
-0.027854988,
0.040509187,
0.002195451,
-0.016802255,
-0.014570706,
0.010212621,
0.0022020142,
0.010357015,
0.16686739,
-0.022328623,
-0.0011986374,
-0.011781269,
-0.00916248,
0.013678086,
0.025347777,
0.0065502543,
0.0046796906,
-0.004876592,
-0.0059956484,
0.0056445077,
-0.0098516345,
-0.0009976339,
0.0060908175,
-0.049881697,
-0.022932453,
-0.0035048453,
-0.003517972,
-0.017235437,
0.016644735,
-0.0038658313,
0.003498282,
-0.000113423426,
0.024901466,
0.004466381,
-0.019217579,
0.0098319445,
0.01900755,
0.0009320001,
-0.034313355,
0.022801185,
-0.007016254,
-0.014701974,
-0.010291382,
-0.0006345969,
-0.0062811556,
0.006340226,
0.005155536,
-0.0073772403,
0.0073838034,
-0.009510339,
-0.006346789,
0.0210422,
0.015345185,
0.036439892,
0.0038461413,
0.002649965,
-0.011164311,
-0.010790198,
-0.03903899,
-0.017077917,
0.007757916,
0.031057918,
0.016789129,
0.0044499724,
0.004230099,
0.017051663,
-0.0024645496,
0.02696237,
-0.025387157,
0.011170874,
-0.02067465,
0.04641623,
0.009195297,
0.0002684833,
-0.0010156832,
-0.0067996625,
0.011420283,
-0.009175607,
0.018823776,
-0.003878958,
-0.03218682,
-0.021396622,
-0.016841635,
-0.0037050284,
0.03218682,
0.00432855,
-0.0019000988,
0.006169578,
0.008013888,
0.014951382,
-0.014557579,
0.001834465,
0.013244903,
-0.029220171,
0.015555213,
-0.0045845215,
-0.036177356,
0.004318705,
0.0029436764,
0.0040135076,
-0.0027418523,
-0.01009448,
0.013428678,
-0.010455466,
0.0175111,
0.0045943665,
-0.011833776,
-0.00005763469,
-0.03636113,
0.06783911,
0.032816906,
0.016421579,
0.007600395,
0.00500786,
0.0047650146,
0.010009156,
-0.017655496,
0.006586353,
0.006356634,
-0.03546851,
0.0040857047,
-0.008814621,
-0.019466989,
0.037411273,
-0.010678621,
-0.011663128,
0.049067836,
0.004092268,
-0.012654198,
-0.015870254,
0.018429974,
0.017983664,
-0.0173142,
-0.005457451,
-0.040929243,
0.0039183386,
0.001605567,
-0.048464004,
-0.0055591837,
-0.008079522,
-0.0011559755,
0.0238382,
0.007515071,
-0.010409522,
0.0023398453,
0.015397692,
-0.01104617,
0.023103101,
-0.009234677,
-0.022998087,
0.0060678455,
-0.0057528033,
0.009392198,
-0.011571241,
-0.0011691023,
0.0156471,
-0.012601691,
-0.03092665,
-0.0165791,
-0.0043548034,
-0.008873691,
-0.0030191552,
0.014386931,
-0.033026934,
-0.0024678311,
-0.039669074,
-0.027224904,
0.008532396,
-0.019650763,
0.017642368,
-0.0017475002,
-0.017209185,
-0.00918217,
-0.004676409,
-0.163822,
-0.020293973,
0.012240705,
-0.031241693,
0.010763945,
0.01605403,
-0.016119663,
-0.020385861,
0.0040660147,
0.020543382,
0.03405082,
-0.020162705,
-0.047492623,
-0.006359916,
0.0033473242,
0.011269325,
0.027933748,
0.036597412,
0.009477522,
0.024533918,
0.012037241,
-0.015279551,
0.010908339,
0.013054565,
0.027513692,
0.016920395,
-0.009037776,
-0.0144131845,
-0.0069900006,
-0.014111269,
-0.009320001,
0.0033768595,
0.024087608,
-0.004535296,
0.010383269,
0.0052835215,
0.01617217,
-0.0144394385,
-0.0077447896,
0.023326255,
0.017602988,
0.013159579,
0.010481719,
-0.0022725707,
-0.024087608,
0.0129036065,
-0.0083420575,
-0.035074707,
0.0144788185,
0.0013052924,
0.008171409,
-0.0009779438,
-0.0025400284,
0.018718762,
0.008138592,
0.00046682046,
0.012076621,
0.009556282,
0.0066749584,
0.007922001,
-0.0020051128,
-0.020897806,
0.018863156,
-0.011761579,
0.0077250996,
-0.04268823,
-0.0023562538,
0.0032078524,
-0.007390367,
0.0030815073,
-0.023155607,
-0.024048228,
0.012096311,
-0.029561467,
0.009228114,
0.01783927,
-0.0051161554,
-0.005802029,
0.015568339,
0.02853758,
-0.019204453,
0.00067479763,
-0.028143777,
-0.02473082,
-0.024901466,
-0.0144394385,
0.0037050284,
0.003307944,
0.010724564,
-0.0098319445,
-0.0038100425,
-0.034365863,
-0.008072958,
0.0017458593,
0.02764496,
0.021475382,
-0.013769973,
-0.0049094087,
0.0099172685,
0.006773409,
0.008388001,
0.0023546128,
-0.02711989,
0.0019805003,
0.016670987,
-0.0074888174,
-0.037595045,
0.013310537,
0.024638932,
-0.0077972966,
0.006839043,
0.0129036065,
-0.0006423909,
0.012050367,
-0.009234677,
0.0059726764,
-0.006041592,
-0.01386186,
0.013454931,
-0.01197817,
0.06547629,
0.0033670145,
0.00022069368,
0.008322367,
0.0049914513,
-0.016355945,
-0.1363083,
-0.031635497,
-0.0005107131,
0.014938255,
-0.0114793535,
0.006241775,
-0.007390367,
0.027697468,
-0.012142255,
0.018338086,
-0.027671214,
0.016119663,
-0.00031422186,
-0.034365863,
0.00731817,
-0.010166677,
0.0017950847,
0.019440735,
-0.027828734,
0.029062651,
0.0010058382,
-0.0032193384,
0.0024514229,
-0.015056396,
0.00009127201,
0.007849803,
-0.025518425,
0.016395325,
0.016421579,
0.0032275426,
0.0046567186,
-0.018955044,
0.027382426,
0.004102113,
0.0012117642,
0.008919635,
0.020727158,
-0.011912537,
0.031162933,
0.000050814924,
-0.01287079,
0.018167438,
0.03599358,
0.004131648,
0.0034621835,
-0.01516141,
-0.0041972823,
-0.0022299087,
0.016067157,
-0.034182087,
-0.04006288,
-0.017681748,
-0.023811946,
-0.010829578,
0.011951917,
0.006825916,
0.016342819,
0.017524227,
-0.004371212,
-0.014964509,
0.01629031,
0.005946423,
-0.0075413245,
-0.004771578,
0.027461186,
-0.012227579,
-0.03454964,
-0.06369105,
0.0129495505,
-0.014964509,
0.005946423,
-0.014754481,
-0.010973973,
-0.008118902,
-0.030086538,
0.019716397,
0.009451268,
-0.011728762,
0.007830113,
0.006245057,
-0.023772566,
-0.0144394385,
0.019965805,
-0.005037395,
0.021265354,
0.0013167782,
-0.002121613,
0.013612452,
0.0038395778,
0.013133326,
-0.022433637,
0.026883608,
-0.0014488663,
-0.015213917,
-0.0021691974,
-0.006235212,
0.00691124,
-0.022394255,
0.03218682,
0.009155916,
0.009096846,
-0.023510031,
-0.041664343,
0.008703043,
-0.019821411,
-0.0044368454,
0.0077250996,
-0.013034875,
0.0032259016,
-0.019926425,
-0.004420437,
0.0046173385,
-0.016644735,
0.00004689228,
0.011151184,
0.009700677,
-0.019873917,
-0.008854001,
0.036439892,
-0.00004017507,
0.01108555,
0.021501636,
0.014610086,
0.013100509,
-0.0059628314,
0.00784324,
-0.011177437,
0.00063254585,
0.005969395,
0.005841409,
0.0045090425,
0.0074494374,
0.020293973,
-0.036387384,
0.00366893,
0.007987634,
-0.013573072,
-0.002958444,
0.026489805,
0.012358846,
0.0129298605,
0.039564062,
-0.035442255,
-0.029902764,
0.01246386,
-0.006563381,
-0.001780317,
-0.006996564,
-0.038120117,
0.009004959,
0.002341486,
-0.03032282,
0.0424782,
0.01779989,
0.01609341,
-0.011650001,
-0.019913297,
0.017248565,
0.0039774086,
0.0035343806,
-0.0005074314,
-0.022407383,
0.0033030214,
0.022459889,
0.009759747,
0.014085015,
-0.017261691,
-0.019480115,
-0.009575972,
0.036623664,
-0.00074904587,
-0.0059103244,
-0.01613279,
0.0058282823,
0.02265679,
-0.002131458,
0.002393993,
-0.0009877888,
-0.009372508,
-0.0083945645,
-0.027986256,
0.03271189,
0.0042268173,
-0.01690727,
0.0020740284,
0.017747382,
0.025623439,
0.0021872467,
0.0050866203,
0.031110426,
0.0083945645,
-0.0051194374,
0.014334424,
-0.004371212,
0.023969468,
0.0072722263,
-0.0034785918,
0.02148851,
-0.007771043,
0.0028419439,
-0.006287719,
0.023811946,
0.02172479,
0.00039503348,
0.010488283,
-0.03798885,
0.0048076767,
0.014662593,
-0.037437525,
-0.01374372,
-0.00089261984,
0.024599552,
0.0052342964,
0.026135383,
-0.004325268,
-0.012660761,
-0.038776454,
0.0129429875,
0.000071581875,
-0.0062778736,
-0.0129036065,
0.026804848,
0.010934592,
-0.0060678455,
0.008571776,
-0.007652902,
0.017064791,
0.021842932,
0.03754254,
-0.01248355,
0.010429212,
-0.004413874,
0.0014784016,
-0.016920395,
-0.063901074,
0.007134395,
-0.0022003734,
-0.03323696,
0.00075560925,
0.01382248,
-0.010895212,
0.06689398,
0.00924124,
-0.020280847,
-0.0027123173,
-0.02007082,
0.0018000072,
-0.007876057,
0.033552002,
-0.018797522,
-0.01661848,
0.024993354,
-0.017445467,
0.0551324,
-0.04762389,
-0.021816678,
-0.0059628314,
-0.025990989,
0.028878877,
0.0021150494,
-0.0033030214,
0.022000453,
-0.027592454,
0.022302369,
0.004975043,
-0.027513692,
0.01613279,
0.0338933,
-0.03441837,
0.01186003,
-0.00094430643,
0.014216283,
0.012713268,
-0.059805527,
0.0028452256,
-0.0083683105,
-0.006786536,
-0.013034875,
-0.015384565,
-0.0026630918,
0.011689382,
0.006671677,
0.010442339,
-0.009786001,
-0.034759667,
0.00046928175,
-0.014688847,
-0.030506594,
-0.009024649,
-0.018863156
] |
Population diversity data have recently provided profound, albeit inferential, insights into meiotic recombination across the human genome, revealing a landscape dominated by thousands of cross-over hotspots. However, very few of these putative hotspots have been directly analyzed for cross-over activity. We now describe a search for very active hotspots, by using extreme breakdown of marker association as a guide for high-resolution sperm cross-over analysis. This strategy has led to the isolation of the most active cross-over hotspots yet described. Their morphology, sequence attributes, and cross-over processes are very similar to those seen at less active hotspots, but their activity in sperm | [
-0.03476154,
0.008990053,
0.0042702756,
-0.020922307,
-0.030784123,
0.03296353,
-0.009296533,
0.0077777584,
-0.019941574,
-0.028196076,
-0.0014421544,
0.0151196355,
0.005772023,
-0.0067799985,
-0.0024978046,
0.024041582,
0.044323687,
-0.00011822857,
0.013192222,
-0.030075815,
-0.04266189,
-0.00474021,
-0.011094543,
-0.016468143,
-0.0022968906,
0.034897752,
0.013559997,
-0.030511696,
-0.021630613,
-0.008983243,
-0.0038718525,
0.0062079043,
-0.013594051,
-0.01654987,
-0.01822529,
0.0087993555,
0.010651851,
-0.01896084,
0.014152523,
-0.030538939,
-0.007491711,
0.0053463574,
-0.020990413,
-0.013989068,
0.0120616555,
0.008921947,
-0.003456403,
-0.0019512502,
-0.023088092,
0.02221633,
0.005581325,
0.02390537,
-0.017653195,
0.0061568245,
-0.012620128,
-0.011149028,
0.010106999,
-0.0015128149,
-0.004014876,
-0.011339727,
-0.0075189536,
0.002717448,
-0.020949548,
0.022161843,
-0.011264809,
-0.0012752935,
0.0007725827,
-0.0034138367,
0.027297072,
0.0043826513,
0.021930281,
0.014874452,
0.0026953134,
-0.006602922,
0.015678108,
-0.024491085,
-0.012368134,
0.007301013,
-0.0071648,
0.0236057,
0.023401381,
-0.016141232,
0.0046278345,
0.03277283,
-0.000026643995,
0.01315817,
0.0023088092,
0.00884703,
0.0057890494,
0.0023122146,
-0.010713147,
0.017408013,
0.032827318,
0.0011876065,
-0.025676137,
0.0043962724,
0.0035619682,
0.009160319,
-0.015923291,
-0.013137737,
-0.012293217,
-0.025825972,
-0.013205844,
-0.01684954,
-0.035033967,
-0.009746036,
0.0149698015,
-0.03181934,
-0.00050143385,
0.011659827,
-0.0027446905,
0.023006365,
-0.02402796,
-0.028713686,
-0.0012020791,
-0.0185522,
0.014588405,
-0.032718346,
-0.021630613,
-0.0054178694,
0.041245274,
0.005731159,
-0.0045665386,
-0.022951879,
0.013178601,
0.027678467,
-0.0301303,
0.011550857,
-0.0011578099,
-0.020990413,
0.0030358457,
-0.0062930374,
0.009555337,
0.0074644685,
-0.04274362,
0.0036368852,
0.0061057447,
-0.002364997,
0.0013408461,
-0.047865223,
0.010025272,
0.03675025,
-0.004855991,
-0.004464379,
0.031247247,
0.023837263,
0.03097482,
-0.011435076,
-0.0024262927,
0.003943364,
0.013137737,
0.0077573266,
0.031764857,
0.018484095,
-0.004876423,
0.021167489,
0.0077232732,
0.0022372974,
-0.019396722,
-0.02581235,
0.010890224,
0.0124498615,
0.010290887,
0.016400037,
0.0007117126,
0.034352902,
-0.0015919886,
-0.012443052,
0.017339906,
-0.02695654,
-0.0046278345,
0.021344567,
-0.02643893,
0.0105496915,
-0.023360517,
0.006868537,
-0.0020125462,
0.008894704,
-0.006381576,
-0.01747612,
-0.0039842282,
-0.011401023,
0.039202083,
-0.003311677,
-0.005506408,
-0.0061942833,
0.019968815,
-0.036096428,
-0.015541895,
-0.0151196355,
0.0010820414,
0.0018695225,
-0.025798729,
-0.010719958,
-0.6376945,
0.010352183,
-0.020213999,
-0.027923651,
0.011428265,
0.0105496915,
0.008193208,
0.015923291,
-0.0007014966,
0.0033848914,
-0.017557846,
0.024409357,
0.0040795775,
-0.015637245,
-0.01990071,
-0.03517018,
-0.0007708801,
-0.00679362,
0.04252568,
0.012088898,
-0.008254504,
-0.009398692,
-0.008595036,
0.028359532,
-0.010284076,
-0.0029319834,
0.031111034,
0.0042396276,
-0.0015792187,
0.006722108,
-0.013008335,
-0.018674793,
-0.01802097,
0.0068276734,
0.0573184,
-0.02917681,
0.016699705,
0.044078503,
0.02265221,
0.046911735,
-0.0053429524,
0.0040387134,
0.02107214,
0.0043213554,
-0.0041306573,
0.004338382,
-0.00062785647,
-0.008506497,
0.006688055,
-0.0096302545,
-0.0086359,
0.0033865941,
-0.012681424,
0.02410969,
-0.02706551,
0.012129761,
0.011864146,
-0.024422979,
-0.009153509,
0.020254863,
-0.019601041,
0.011632584,
-0.0022662426,
-0.023197062,
-0.01991433,
0.010011651,
-0.013777938,
-0.010209159,
0.004821938,
0.006139798,
-0.0005393181,
0.022475135,
-0.012892554,
0.006647191,
-0.002797473,
0.0077573266,
-0.010597366,
0.0023479704,
-0.0149698015,
0.006752756,
0.0030358457,
0.012722288,
-0.021889418,
-0.005969532,
0.022870151,
0.009575769,
-0.024790753,
0.024504706,
0.010236402,
-0.012926607,
0.010794875,
0.00077556237,
-0.0026357202,
-0.03309974,
-0.010338562,
0.020445561,
-0.0015426114,
0.008819788,
0.018919976,
-0.022298057,
-0.025526304,
-0.02687481,
-0.0027395827,
-0.013573619,
0.020622637,
0.00531571,
-0.01569173,
-0.009637065,
0.0033491354,
-0.021630613,
-0.011966306,
-0.0050739315,
-0.008397527,
-0.010066136,
-0.006752756,
-0.028141592,
0.008070616,
0.009963976,
-0.0001255713,
-0.020064164,
0.0152694695,
0.0063236854,
0.0056766737,
-0.03887517,
0.02906784,
0.009330586,
-0.0040625506,
-0.0057243486,
0.011618963,
-0.04173564,
-0.020513667,
-0.0085609825,
0.0037458555,
-0.01506515,
0.0035994267,
-0.006762972,
-0.00542468,
0.0044745947,
-0.023946233,
-0.02559441,
-0.041245274,
0.0053054937,
-0.0072192852,
-0.002516534,
-0.0156236235,
-0.036804736,
-0.028931627,
-0.008513308,
0.009991218,
0.008165965,
0.018456852,
0.010624609,
-0.020636259,
0.016113989,
-0.008486066,
-0.0048151272,
-0.015541895,
-0.025104044,
0.0072192852,
-0.014710996,
0.008022942,
-0.0014949369,
-0.01306282,
0.0027004213,
-0.0051454436,
0.003813962,
0.0011152434,
-0.011387401,
-0.018456852,
-0.015514653,
0.005179497,
-0.031165518,
-0.024872482,
0.030212028,
-0.008601846,
0.000037564972,
-0.01623658,
-0.0028417422,
0.009099023,
-0.0012216597,
-0.011857335,
-0.023592079,
-0.02539009,
-0.028059864,
0.024164174,
0.006214715,
0.034598086,
-0.0033627567,
-0.002395645,
0.017285421,
0.003427458,
0.004699346,
-0.012552022,
0.013675778,
0.018879112,
-0.002874093,
0.003960391,
0.027501391,
-0.010529259,
0.023047227,
0.049744964,
-0.006888969,
-0.007825433,
-0.018484095,
0.021099383,
-0.037022676,
-0.004307734,
-0.02454557,
0.019859845,
-0.008336231,
0.009786899,
0.002732772,
-0.00842477,
0.0018201453,
0.000575074,
-0.014384085,
-0.022911016,
0.0012761449,
0.028250562,
0.009752846,
0.0037935302,
0.0154465465,
0.015501032,
-0.009562148,
-0.013764317,
0.00023964963,
0.00037650106,
0.009180752,
-0.0029047409,
0.0037628822,
-0.006776593,
0.023619322,
0.007941214,
0.017448876,
0.013117305,
-0.0042294115,
0.0016345552,
-0.012265975,
0.021753205,
0.010862981,
0.021194732,
0.020622637,
-0.0034836456,
-0.0098686265,
0.008043374,
-0.013451027,
0.0158007,
0.015555517,
0.005169281,
0.012511157,
-0.005496192,
-0.010651851,
-0.00726696,
0.0046312395,
0.006858321,
-0.00884703,
-0.0028196077,
0.004416704,
0.04108182,
0.027515013,
0.003018819,
-0.014302358,
0.011360158,
-0.0034598084,
-0.008772112,
0.009814141,
-0.001983601,
0.006150014,
-0.015827943,
0.016045883,
-0.0015970967,
-0.008404338,
0.005329331,
-0.021521643,
-0.031628642,
0.017612332,
0.021548886,
0.0040284973,
0.011952685,
-0.00832942,
-0.033126984,
-0.030293755,
0.027555875,
0.024354871,
-0.01063823,
-0.014479435,
-0.010209159,
0.01612761,
-0.01569173,
0.014247873,
0.020622637,
-0.0083158,
-0.008595036,
-0.0038786633,
-0.009439556,
-0.022924636,
0.028087106,
-0.012878933,
0.0051352275,
0.0048389644,
0.008050185,
0.011012816,
-0.027242586,
-0.021971146,
0.041844614,
0.017857516,
-0.0073078237,
-0.018375125,
-0.008983243,
-0.0055983514,
-0.0053020883,
-0.006698271,
-0.024817996,
0.014819967,
-0.026602386,
-0.015473789,
0.003034143,
0.0032571917,
0.014724618,
0.005509813,
-0.026779462,
-0.0118982,
-0.008567793,
0.004910476,
0.051570214,
0.026942918,
-0.01927413,
0.008152344,
0.018102698,
-0.0040931986,
-0.014833588,
-0.0151196355,
0.024096068,
-0.036477823,
-0.003250381,
-0.007743705,
0.013914151,
-0.002753204,
0.019314993,
0.0074304156,
-0.0009781792,
-0.019641904,
-0.024191417,
0.0316014,
-0.021330945,
0.011101354,
0.0052884673,
0.03781271,
0.037976164,
-0.0023156197,
0.027692089,
0.029966844,
0.021521643,
-0.007941214,
-0.018797385,
0.025717001,
0.004634645,
0.0229655,
0.0034512952,
-0.004917287,
0.02370105,
-0.0040080654,
-0.0019597635,
-0.011210324,
0.03740407,
0.014247873,
0.011121786,
0.021916661,
-0.006541626,
-0.021508021,
0.008206829,
0.007805001,
-0.01612761,
-0.03803065,
0.019996058,
-0.021930281,
-0.009432745,
-0.017653195,
-0.013021956,
-0.0044916216,
-0.0010062731,
-0.016495386,
-0.019791739,
-0.0036947757,
-0.017639576,
-0.003899095,
0.009746036,
-0.00020006274,
-0.017980106,
-0.0288499,
-0.012892554,
-0.026357202,
-0.020554531,
-0.0015383548,
0.0015128149,
-0.015133257,
-0.030103058,
-0.010515639,
0.041190792,
0.02402796,
-0.0001809078,
-0.0288499,
-0.0067459457,
0.016876781,
-0.011714312,
-0.008302178,
-0.015092392,
-0.01274953,
0.0110536795,
0.017190073,
0.0065041673,
-0.032800075,
-0.002616991,
0.03108379,
-0.0059899637,
-0.020091407,
-0.016400037,
0.00032435704,
-0.009024107,
0.023156198,
-0.00020644773,
0.032364193,
-0.0010556502,
-0.017503362,
0.01623658,
-0.04129976,
-0.0107472,
-0.03432566,
-0.014574784,
0.0061636353,
-0.021807691,
-0.0018235507,
-0.005887804,
-0.006143203,
-0.0044711893,
-0.021998389,
0.010161485,
0.0025420738,
0.035932973,
0.015882429,
0.010672283,
0.008084238,
-0.00059891125,
-0.0030290352,
-0.0011339727,
-0.009827763,
0.0152967125,
0.002969442,
-0.01253159,
0.03266386,
-0.015868807,
-0.0064701145,
-0.017394392,
0.005581325,
-0.014901695,
0.040618695,
-0.0007419348,
-0.037322342,
-0.00563581,
-0.0055336505,
0.0044303257,
0.020064164,
-0.00009002823,
-0.013641725,
-0.012490726,
0.009739225,
-0.015541895,
-0.0075053326,
0.025253877,
-0.036859218,
0.0032895424,
0.019641904,
-0.013859666,
0.0017912,
0.0043247608,
0.0003286137,
-0.003769693,
-0.032609377,
-0.018211668,
-0.014819967,
-0.010304508,
0.0009943544,
0.03476154,
0.040400755,
0.050180845,
-0.007539386,
-0.0042362222,
0.025294742,
0.0077913795,
-0.01158491,
0.0029013355,
0.0062113097,
-0.014302358,
0.0033440276,
0.03304526,
0.0154465465,
-0.0110536795,
-0.019437585,
0.025744244,
0.030184785,
-0.020091407,
-0.023251547,
-0.002097679,
-0.051216062,
0.003366162,
-0.011918631,
0.0040387134,
-0.0047844793,
-0.046421368,
0.014029932,
0.049009413,
-0.004287302,
0.00979371,
0.011789229,
0.009126266,
0.003943364,
0.0236057,
-0.016304689,
0.0060103955,
-0.022025632,
-0.021412672,
-0.0237964,
0.0026833948,
0.035851244,
-0.0047333995,
0.020745229,
0.015024287,
-0.0071375575,
-0.0046176184,
0.018388746,
-0.015637245,
0.01958742,
0.0057686176,
-0.033208713,
0.011639395,
0.001155256,
-0.008131912,
-0.03718613,
-0.0015034502,
-0.011312484,
-0.005887804,
0.016113989,
0.00092880195,
-0.009603011,
0.015950534,
0.029612692,
0.03285456,
-0.034516357,
0.02474989,
0.013764317,
0.011870957,
-0.038384803,
-0.008595036,
-0.0063236854,
0.0146156475,
0.0372951,
0.01537844,
-0.006425845,
-0.027297072,
0.0024926967,
-0.014983422,
-0.010406668,
-0.04636688,
0.0030835203,
-0.0045971866,
0.005094364,
-0.009357829,
0.0030205217,
-0.0019631688,
0.020595396,
-0.02676584,
0.010236402,
0.01897446,
-0.018198047,
-0.007927593,
0.02612564,
-0.006456493,
0.012858501,
-0.00055549335,
-0.011632584,
0.0031431133,
-0.01800735,
-0.0031873826,
0.0016924457,
0.004600592,
0.020500045,
-0.029040597,
-0.0070217764,
-0.0029881713,
0.012497537,
-0.033235956,
-0.008349853,
0.0011748365,
0.04478681,
-0.008840219,
0.01442495,
0.015010665,
0.011407833,
-0.0012037818,
0.02011865,
-0.016604356,
-0.0072397175,
0.0080569945,
0.0012804016,
0.021930281,
0.0055881357,
0.014751861,
-0.0059422893,
-0.003950175,
0.024477463,
-0.018906355,
-0.023878127,
0.002097679,
-0.042607404,
-0.008172776,
0.012504347,
0.011782419,
0.02137181,
0.010754011,
-0.018252533,
-0.017639576,
0.010147863,
-0.026152883,
0.023837263,
0.02107214,
0.021848554,
-0.030184785,
0.013485081,
0.0060580703,
-0.011251188,
0.014520299,
-0.016863162,
-0.014561162,
0.008002509,
0.005148849,
0.015255848,
0.017680438,
0.009235237,
0.0010701228,
0.0035721841,
0.0051556593,
0.001487275,
-0.018061835,
0.018565822,
-0.02844126,
-0.011877768,
0.017394392,
-0.009024107,
0.01317179,
-0.014888073,
0.0014268304,
0.012647371,
-0.011326105,
0.0077913795,
-0.014029932,
0.009439556,
0.0005082445,
0.021834932,
-0.0017946054,
-0.013028767,
-0.026166504,
0.024695404,
0.008084238,
-0.011469129,
0.016481765,
0.01610037,
-0.01063142,
0.012844879,
-0.00842477,
0.00463805,
0.0051863072,
-0.0076960307,
-0.058571562,
-0.0011603639,
0.0022321895,
0.018797385,
0.04563133,
-0.029585449,
-0.026207369,
-0.0012191058,
-0.03824859,
-0.028904384,
0.01338292,
0.01601864,
0.0036641278,
0.027896408,
0.005428085,
0.012402187,
-0.011939064,
0.026329959,
-0.013825612,
-0.0051556593,
0.025308363,
0.00037118024,
0.023346897,
0.015024287,
-0.034434628,
-0.003970607,
0.03789444,
0.000028067314,
-0.005751591,
0.039338294,
-0.011666638,
0.023360517,
0.007805001,
-0.001500045,
0.00051718345,
0.0055166236,
0.023006365,
-0.06881477,
-0.013253518,
0.00979371,
0.00006619097,
-0.006657407,
0.013355678,
-0.019069811,
0.004981988,
0.00531571,
-0.024926966,
-0.020813337,
0.013178601,
-0.00811829,
-0.0017316069,
0.030484455,
-0.011108165,
0.020813337,
0.012783583,
-0.0003807577,
-0.0010147863,
-0.019246887,
-0.022883773,
0.01232046,
-0.00009944608,
-0.017217314,
0.0065041673,
-0.01379837,
0.019601041,
0.003739045,
0.010202348,
-0.021399051,
-0.017353527,
-0.022243572,
0.022733938,
0.0139618255,
-0.00038160905,
-0.0019580608,
0.009419125,
-0.013818802,
-0.013301193,
0.015214984,
-0.0018627119,
-0.014629269,
0.03296353,
0.009562148,
-0.021044899,
-0.013416974,
0.010032082,
-0.0012216597,
-0.024695404,
0.028686443,
0.1976722,
-0.020445561,
-0.019859845,
0.03631437,
0.01347827,
-0.012974282,
0.020881442,
-0.0008228112,
0.0070694513,
0.000008273872,
0.022311678,
0.006122771,
-0.035142936,
-0.0107267685,
0.038575504,
-0.024654541,
-0.025444577,
-0.012082087,
-0.0149698015,
0.010828928,
0.0193831,
0.0070013446,
-0.008050185,
-0.009507663,
0.02338776,
-0.022774803,
-0.014152523,
-0.0061363927,
-0.017612332,
0.0136349145,
-0.02706551,
0.015351198,
-0.0052510086,
-0.005877588,
-0.0032844343,
0.007682409,
0.024913345,
0.005605162,
0.009882248,
-0.02265221,
-0.015896048,
0.0063236854,
0.019314993,
-0.016481765,
-0.00081770326,
-0.0042702756,
0.008826598,
-0.012838068,
-0.0032674077,
-0.003974012,
-0.028196076,
0.008724438,
-0.0015213282,
0.034053233,
-0.020023301,
0.008765303,
0.024804374,
0.0026748814,
0.0047027515,
0.03119276,
-0.009119456,
0.011870957,
-0.027678467,
0.0030137112,
-0.019301372,
0.022693075,
-0.007355498,
0.020391075,
0.016005019,
0.006579085,
0.009500852,
-0.033426654,
-0.01506515,
-0.01453392,
-0.005717538,
-0.0019631688,
0.037649255,
0.01169388,
0.024123311,
-0.0016856351,
0.013730263,
-0.00035181246,
-0.0031822745,
0.0092148045,
0.011925442,
-0.031764857,
0.021508021,
-0.00400466,
-0.011870957,
0.013485081,
-0.00884703,
-0.023537595,
-0.005642621,
-0.032718346,
-0.016386416,
-0.018170806,
0.01021597,
-0.0037833143,
-0.03590573,
-0.019614663,
-0.02969442,
0.037267856,
0.02653428,
0.0018184426,
0.00916713,
-0.009889059,
0.0062487684,
0.032909043,
-0.005233982,
-0.010495206,
0.021916661,
-0.022338921,
0.015746215,
-0.009780088,
0.005574514,
0.014275115,
0.031955555,
-0.063529715,
0.022161843,
0.010147863,
-0.02212098,
-0.03495224,
0.0013987365,
0.017775787,
-0.0144658135,
-0.021017656,
-0.010910655,
-0.0032725157,
-0.02032297,
-0.0036300747,
0.01590967,
-0.009916302,
0.015460168,
0.0038105568,
0.009882248,
-0.03244592,
-0.021004034,
-0.0141116595,
-0.008622278,
0.003437674,
0.007035398,
-0.01200717,
0.0039263377,
0.030103058,
-0.010181917,
-0.018129941,
-0.00046950896,
0.03138346,
-0.021630613,
-0.007879918,
0.00873806,
-0.008751681,
0.0037833143,
0.012402187,
0.015664486,
-0.013600862,
-0.0038003407,
-0.031247247,
0.012647371,
0.005465544,
-0.005863967,
0.025989428,
0.015364818,
-0.002490994,
-0.0014532217,
-0.0029915764,
-0.17326285,
0.0012191058,
0.012790394,
-0.017775787,
0.018361503,
0.022788424,
0.028087106,
0.014697376,
0.029149568,
-0.00029754013,
0.023959855,
0.010985573,
-0.0128653115,
-0.008445201,
0.014098038,
0.01886549,
-0.011571288,
0.036913704,
0.020895064,
0.016400037,
0.009092214,
-0.015174121,
0.008431581,
-0.016168475,
0.012599696,
0.0069332384,
-0.008615468,
0.027610362,
0.017285421,
-0.036614034,
-0.01232046,
-0.0018729278,
0.01969639,
-0.016577113,
-0.0008836814,
0.0086495215,
-0.01442495,
0.004338382,
-0.012511157,
-0.00056911464,
0.03552433,
0.007927593,
0.0018439826,
-0.00521355,
-0.011789229,
-0.0023871316,
-0.0035755895,
-0.02876817,
0.01484721,
-0.00042055742,
0.011394212,
-0.0053565735,
0.030811366,
0.019124296,
0.021344567,
-0.0015170715,
0.007941214,
0.024082446,
-0.00076619774,
0.0035721841,
-0.013008335,
-0.009616633,
0.015868807,
-0.007205664,
-0.00033116768,
-0.024817996,
-0.011503182,
0.02307447,
-0.036150914,
-0.008785734,
-0.0064939517,
0.010495206,
0.009603011,
0.003165248,
0.012586075,
0.006088718,
-0.01883825,
0.01642728,
0.030729637,
-0.02517215,
-0.017421633,
0.021017656,
-0.023837263,
0.007151179,
-0.00028030068,
-0.009003675,
0.001477059,
0.014125281,
-0.004866207,
0.009841384,
0.02421866,
-0.022393405,
0.021889418,
-0.020976791,
0.04287983,
0.004890044,
-0.012368134,
0.014860831,
0.0039535803,
-0.001987006,
-0.012565643,
-0.007832243,
-0.028141592,
0.007913971,
0.037567526,
-0.015977778,
-0.00653141,
0.012197868,
0.027542254,
-0.010590555,
-0.010713147,
-0.01875652,
0.0053770053,
0.019423964,
-0.0022747559,
0.049309082,
-0.0011765392,
-0.0020670313,
0.006974102,
-0.011830093,
0.054512415,
-0.009255669,
0.01074039,
-0.015746215,
-0.014016311,
0.0029728473,
-0.122482665,
-0.0043656244,
0.0066403802,
0.01631831,
-0.017312663,
0.012804016,
-0.013505512,
0.031655885,
-0.01758509,
0.039256565,
-0.031846583,
-0.01905619,
-0.021004034,
-0.004600592,
0.012402187,
0.0035381308,
-0.0023122146,
-0.005077337,
0.011394212,
0.026098398,
0.0016132719,
-0.017762166,
-0.012660992,
-0.010760821,
-0.016835919,
0.017203692,
-0.014506677,
0.0104271,
0.010386236,
0.011189892,
-0.0067595667,
-0.012660992,
0.010066136,
-0.03119276,
-0.014588405,
-0.012436241,
-0.0028196077,
-0.05372238,
0.01274953,
-0.00044822568,
-0.014901695,
0.023455868,
0.015841564,
-0.011339727,
0.010658662,
-0.0058741826,
0.010270455,
0.01916516,
-0.012804016,
-0.024491085,
-0.014670133,
0.002038086,
-0.019982437,
-0.01652263,
-0.006551842,
0.004386056,
0.0013076442,
-0.010474774,
-0.025580788,
-0.00068191596,
-0.006098934,
0.006923022,
-0.006814052,
0.0027600145,
0.008758492,
-0.016999373,
-0.022420648,
-0.04252568,
0.0051045795,
-0.019192401,
-0.03211901,
0.0035755895,
-0.025403712,
0.005063716,
-0.0018576039,
0.00048823823,
-0.008206829,
-0.020350212,
0.009998029,
-0.0045801597,
-0.020690745,
-0.034271173,
0.0147927245,
-0.011189892,
0.014915316,
-0.0028996328,
0.0069877235,
-0.0022934852,
-0.000393102,
-0.015323955,
-0.009603011,
0.05004463,
-0.012381756,
-0.0402373,
-0.024477463,
0.012354513,
-0.0059559103,
0.003327001,
0.010583744,
0.00016664801,
-0.034570843,
-0.0072942027,
-0.057427373,
0.016182097,
0.021535264,
-0.0072397175,
0.0074440367,
-0.02969442,
0.010256833,
0.01897446,
-0.0070830723,
0.032582134,
0.0003599001,
0.0074712792,
-0.010086567,
-0.013124116,
-0.027678467,
-0.024804374,
0.012858501,
0.0054485174,
0.021113005,
0.030457212,
0.010263644,
-0.0073078237,
0.027692089,
0.002158975,
-0.004011471,
0.008274935,
-0.011080922,
0.02528112,
0.0026510442,
0.006024017,
0.014642891,
-0.012334081,
-0.030675152,
0.017898379,
-0.007825433,
0.0019359263,
-0.0065450314,
0.0057379697,
0.016400037,
0.029204052,
-0.031465188,
-0.02285653,
-0.005179497,
0.0142887365,
-0.019778118,
0.027978135,
-0.009963976,
0.023060849,
-0.0054110587,
-0.0001835682,
0.034816027,
0.011857335,
0.0123885665,
-0.030402726,
-0.011312484,
0.011612153,
-0.0011109867,
0.021017656,
0.013737074,
-0.019655526,
0.023197062,
0.02011865,
0.020554531,
0.0017520388,
0.008554172,
-0.009725603,
-0.025907699,
0.0057447804,
-0.0074508474,
-0.013948204,
-0.021017656,
0.020826958,
0.010862981,
0.027133616,
-0.013464648,
-0.021848554,
-0.010556502,
0.011959495,
-0.0017894974,
0.012831259,
0.0041783317,
0.0010658662,
-0.0069877235,
0.020622637,
0.010474774,
-0.012763152,
-0.018606687,
0.017653195,
-0.025757866,
0.015759837,
0.0057073217,
0.010869792,
0.0136349145,
0.0064633037,
-0.023769157,
0.01883825,
-0.023142576,
-0.014275115,
0.019846223,
0.011639395,
-0.0010862981,
0.021344567,
0.018851869,
-0.03688646,
0.0003950175,
0.01980536,
0.00024199078,
-0.02695654,
-0.008622278,
0.004781074,
0.030838607,
-0.00032542122,
-0.007920782,
0.0023820237,
-0.0031720586,
-0.011155839,
0.005952505,
-0.010624609,
-0.011366969,
0.029748904,
0.015351198,
0.0035585628,
0.005782239,
0.008397527,
0.041490458,
-0.004743615,
0.029204052,
-0.030266514,
0.0031039522,
-0.009262479,
0.038629986,
-0.011830093,
-0.02833229,
-0.00020474507,
0.00873806,
-0.004845775,
0.02401434,
0.016113989,
-0.010420289,
0.073881894,
0.026888432,
-0.015528274,
0.0052305767,
-0.016931267,
0.035851244,
0.012967471,
0.0018303613,
-0.018279776,
-0.035333633,
0.024395736,
-0.023115335,
0.03138346,
-0.0073827407,
-0.004624429,
0.014043553,
-0.017993728,
0.0053020883,
-0.007730084,
-0.04258016,
0.018633928,
-0.057645313,
0.024709025,
0.029612692,
-0.017408013,
-0.0075257644,
0.02190304,
-0.008629089,
0.0026476388,
0.003773098,
0.015201363,
-0.02126284,
-0.03190107,
-0.0052646296,
-0.013355678,
-0.0029983872,
0.013948204,
-0.02506318,
0.04865526,
0.014765481,
-0.007886728,
0.0007742854,
-0.018402368,
0.0022219734,
0.016113989,
0.008465634,
0.0021725963,
0.0073963623,
-0.0077096517
] |
The generation of induced pluripotent stem cells (iPSCs) provides the opportunity to use patient-specific somatic cells, which are a valuable source for disease modeling and drug discovery. To promote research involving these cells, it is important to make iPSCs from easily accessible and less invasive tissues, like blood. We have recently reported the efficient generation of human iPSCs from adult fibroblasts using a combination of plasmids encoding OCT3/4, SOX2, KLF4, L-MYC, LIN28, and shRNA for TP53. We herein report a modified protocol enabling efficient iPSC induction | [
-0.014254014,
0.013074914,
0.010854275,
-0.03390569,
-0.019101428,
0.0025498047,
-0.02501003,
0.01502698,
-0.021839561,
-0.016703922,
0.010061657,
0.0067667263,
0.0033735374,
0.0152365975,
-0.022743538,
0.020267427,
0.035268206,
-0.0033424222,
-0.008522276,
0.025678188,
-0.025167244,
0.015878553,
0.015092486,
-0.0038451776,
-0.0094786575,
0.033931892,
-0.002512139,
-0.017673405,
-0.0152628,
-0.022795942,
0.0093476465,
0.011784454,
-0.013055262,
-0.003543852,
-0.0067208726,
0.0012601636,
-0.0033866386,
-0.0050046262,
-0.004965323,
-0.0039139586,
0.007854119,
0.008057186,
-0.008397816,
0.0041465033,
0.009111826,
-0.001185651,
-0.0046312446,
-0.010932881,
-0.011607589,
0.018918011,
0.01361206,
-0.015668934,
0.004601767,
0.012347802,
-0.008299557,
-0.026320143,
0.0046901996,
0.01232815,
0.01573444,
-0.008293007,
-0.007880322,
0.0016253572,
-0.02066046,
0.012400206,
-0.014817363,
0.018970417,
-0.002834754,
0.0059479065,
0.006747075,
-0.00798513,
0.03382708,
0.0005359175,
-0.0131404195,
-0.0054762666,
0.0074021304,
-0.0063671423,
-0.021970572,
-0.022926953,
-0.006704496,
0.010716713,
0.008279906,
-0.03039459,
-0.0021518583,
0.024970727,
-0.0013412267,
0.01585235,
-0.003229425,
0.016337091,
0.013186273,
-0.000588322,
0.021171404,
0.034272518,
0.010507095,
0.0044052503,
-0.029503712,
0.01902282,
-0.011948218,
0.033119623,
0.0060952944,
-0.033800878,
-0.0064621256,
0.012046476,
-0.010972185,
-0.025534075,
-0.050648917,
0.012419858,
0.028927265,
-0.006995996,
0.024944525,
0.013677565,
-0.009950298,
0.01654671,
-0.00095064973,
-0.033538856,
0.039277148,
-0.0040253177,
0.0022271897,
0.008522276,
-0.032097735,
-0.008463321,
0.029189287,
0.012636026,
0.0020142966,
-0.009891342,
0.008135793,
0.010035455,
-0.026713176,
0.009557264,
-0.014529138,
-0.0058037946,
0.014725654,
-0.0059970357,
-0.0029313748,
0.03215014,
-0.029058276,
-0.012786689,
0.0019094876,
-0.005165115,
-0.020752167,
-0.026503557,
-0.02546857,
0.016219182,
-0.0036486608,
0.0010808421,
-0.014267115,
0.015773743,
0.023450999,
-0.013978891,
0.02487902,
0.01950756,
0.001358422,
0.0021518583,
0.02769576,
-0.0013011046,
-0.007015648,
0.021564437,
0.027302725,
0.029608522,
-0.009406601,
0.0037338182,
-0.006000311,
-0.02136792,
0.00751349,
0.01044814,
0.008076838,
0.019992303,
-0.00034636076,
0.020123314,
0.022114685,
-0.007185962,
-0.0073890295,
0.021774055,
-0.021302415,
0.013821677,
-0.01562963,
0.005145463,
0.0029100855,
0.010028904,
-0.032019127,
-0.024761109,
-0.014175408,
0.034534544,
0.014882868,
0.0067667263,
-0.01807954,
-0.0029968803,
0.016887339,
-0.017476888,
-0.016939742,
-0.028141197,
0.0049587726,
0.0035504024,
0.0051716655,
-0.03215014,
-0.63723826,
-0.055601135,
0.025167244,
-0.014764958,
0.031861912,
0.03815045,
0.02147273,
-0.024787312,
-0.0051978678,
0.013834778,
-0.00797858,
0.024119155,
0.006478502,
-0.017869921,
-0.010749466,
-0.029791938,
-0.019180033,
-0.01150933,
0.0055810753,
0.0039630877,
-0.027669556,
0.00086876773,
-0.015668934,
0.022586323,
0.0044904076,
0.008384714,
0.02735513,
-0.015668934,
-0.007009097,
0.04485822,
-0.0016867687,
0.025979513,
0.004755705,
-0.01610127,
0.049233995,
-0.0016949569,
-0.025769895,
0.015275901,
0.034272518,
0.03804564,
-0.0011316088,
-0.003720717,
0.011614139,
0.011607589,
-0.017804416,
0.01538071,
0.007009097,
0.003429217,
-0.013022509,
0.021184504,
0.016808731,
0.0066422657,
-0.026857289,
-0.0063311146,
0.0093935,
0.004356121,
0.0018701843,
-0.01797473,
0.028743848,
-0.007441434,
-0.00043028977,
0.024499087,
-0.030368388,
-0.018105742,
0.011397971,
0.023293784,
0.0029264619,
-0.014109902,
0.017083855,
-0.03275279,
0.0066520916,
0.028481826,
-0.025272053,
-0.0076314,
0.00033039378,
0.017673405,
0.0014894331,
0.0022370156,
-0.0028789702,
-0.013939587,
0.0060494402,
-0.006200103,
-0.011155601,
0.018498776,
0.01983509,
0.023057964,
-0.030682813,
0.026346345,
-0.016965946,
0.015472418,
0.016939742,
0.013323835,
0.027066905,
-0.05471026,
-0.019913696,
-0.00061124895,
0.0039630877,
-0.0036945147,
0.0045952164,
-0.010873926,
-0.01361206,
0.0058758506,
0.0103957355,
0.004189082,
0.024748009,
0.012550869,
-0.03390569,
0.0093935,
0.046404153,
-0.05211624,
0.016952844,
0.0005981478,
0.003707616,
-0.011234207,
-0.005705536,
-0.015904754,
-0.009406601,
-0.008594332,
-0.008555029,
-0.028560434,
0.020372236,
-0.007087704,
-0.008764647,
0.021420324,
0.014411228,
0.005859474,
-0.0012437872,
-0.006773277,
0.0076248497,
-0.013690666,
-0.011915465,
-0.0293465,
0.01597026,
-0.03812425,
0.016153676,
-0.01538071,
0.006547283,
-0.009190433,
0.017581698,
-0.02358201,
-0.027538545,
0.00015629223,
0.005155289,
-0.008240602,
-0.0008401091,
0.0011078632,
-0.014633947,
-0.014529138,
0.02453839,
-0.016625317,
0.0017342602,
-0.012963554,
0.003393189,
0.00657676,
0.015013879,
-0.015511721,
-0.0068977377,
-0.024197761,
0.014398127,
-0.016795631,
-0.0269883,
0.03828146,
0.00065874046,
0.0058627496,
0.021498932,
-0.01714936,
-0.0269883,
0.00434302,
-0.020201921,
-0.021066595,
0.0001328535,
-0.0048179356,
-0.013651363,
0.016743226,
-0.012904599,
0.0046541714,
0.009583467,
-0.011646892,
-0.0122298915,
-0.006301637,
-0.012976656,
-0.030368388,
-0.0006460488,
0.003825526,
0.021512033,
0.010729814,
0.028114995,
0.008613984,
0.015459317,
0.024603896,
0.007500389,
-0.0034947228,
0.0015008966,
0.011889263,
0.034089103,
-0.009308343,
0.0027987259,
0.0152628,
-0.0022926952,
0.0147125535,
0.032097735,
-0.008659838,
0.013068363,
-0.023988143,
0.027171714,
-0.03710236,
0.007054951,
-0.020791471,
0.0053223283,
0.028272208,
-0.0029133607,
0.008725343,
-0.017188665,
-0.0038157,
0.008528827,
0.0050635813,
0.0038091494,
-0.017804416,
0.0011659993,
-0.013225577,
-0.0057808673,
0.0017702883,
0.022153987,
-0.0016613853,
-0.0014558615,
0.020293629,
0.012943903,
0.016861137,
0.01597026,
-0.0063671423,
-0.0019913695,
0.0047851824,
0.007323524,
0.0035897058,
0.014699453,
0.027407534,
0.0007877046,
-0.017044552,
0.04155674,
-0.010042005,
0.0071663107,
0.018014034,
0.007218715,
-0.0011905639,
-0.012118532,
0.0005801338,
0.03335544,
-0.0068256813,
-0.012819442,
0.016926643,
-0.03131167,
0.024472885,
-0.019625472,
0.020450842,
0.014175408,
-0.020437742,
0.0037534698,
0.018092642,
0.0090921745,
0.011221106,
0.013690666,
-0.013291082,
-0.011319364,
-0.014751856,
0.0011095008,
0.0047524297,
-0.0037403686,
-0.014424329,
-0.03159989,
-0.00010399011,
-0.027512344,
0.013677565,
0.021931268,
-0.033276834,
0.0020536,
-0.00017696741,
0.018577382,
-0.00797858,
0.020031607,
-0.0060134125,
-0.015328306,
-0.028141197,
0.017529294,
0.011470027,
-0.00093099807,
0.0034161161,
-0.020228123,
-0.03710236,
0.0010685598,
-0.0048539634,
0.009295242,
-0.013304183,
0.008751545,
-0.00042332982,
-0.0039368854,
-0.015917856,
0.007605198,
-0.016834933,
0.032438364,
0.0061051203,
-0.0003308032,
-0.015537923,
-0.0050406544,
-0.034193914,
0.036447305,
0.0058267214,
-0.0019193135,
-0.006498154,
-0.004048245,
-0.020608056,
-0.0019749932,
-0.014961475,
-0.007932725,
-0.001999558,
-0.0036421102,
0.0051945923,
0.011470027,
0.0036060822,
0.036368698,
-0.016481204,
-0.010015803,
-0.037285775,
-0.02030673,
-0.01620608,
0.029398905,
0.029870545,
-0.008489523,
0.0029149982,
0.002307434,
-0.0021551335,
-0.00079875864,
-0.02054255,
0.023542706,
-0.008817052,
0.018092642,
0.0079065235,
0.005728463,
-0.005646581,
-0.006956693,
0.021118999,
-0.014948374,
-0.02312347,
-0.018904911,
-0.00786722,
0.0064129964,
-0.0013731607,
0.0076248497,
0.026202232,
0.03254317,
-0.0023221727,
0.009196984,
0.021433426,
-0.03125926,
0.008758096,
-0.020752167,
0.007533142,
0.002212451,
-0.00042414863,
0.0010341693,
-0.02324138,
0.0022206393,
0.009255938,
0.004627969,
0.016952844,
0.022717334,
0.029844342,
0.012111981,
-0.018131945,
-0.002965765,
-0.0046770982,
-0.02877005,
-0.027512344,
0.002985417,
-0.0269883,
0.011227656,
-0.026123626,
-0.03099724,
-0.013821677,
-0.0057088113,
0.011646892,
-0.006727423,
-0.018695293,
0.013677565,
-0.0071597598,
0.011175252,
-0.018669091,
0.0043364693,
0.010598803,
-0.011057342,
-0.022822144,
0.012688431,
-0.007526591,
-0.030499399,
-0.0031622818,
0.020987988,
-0.006950142,
-0.01936345,
0.023896435,
0.0037370934,
0.014961475,
0.01315352,
-0.0018849231,
0.0033456974,
0.023529604,
-0.00469675,
-0.025494771,
0.005283025,
-0.023555806,
0.009406601,
0.0070615015,
-0.014751856,
-0.013782374,
0.011325914,
0.005810345,
0.034010496,
0.0027790742,
-0.020817673,
-0.007526591,
-0.013415542,
0.017542394,
0.04061346,
-0.000415551,
-0.013874082,
-0.003959812,
-0.010500545,
-0.042657234,
-0.021800257,
-0.026438052,
-0.009668624,
-0.0014894331,
-0.017909225,
-0.006088744,
-0.023778526,
-0.026097422,
0.020123314,
0.0066258893,
0.022625627,
-0.00056948914,
0.01514489,
0.020372236,
-0.014371924,
0.0028822455,
0.014214711,
-0.011188353,
-0.012989757,
-0.008738444,
0.039617773,
-0.00498825,
-0.02793158,
-0.0009121652,
0.025534075,
-0.014751856,
-0.0269883,
-0.007493838,
-0.015642732,
0.04003701,
-0.01255742,
-0.0041465033,
-0.019966101,
-0.0035831553,
0.009557264,
0.0061214967,
0.008967714,
-0.01585235,
0.007932725,
0.011476577,
0.022848347,
-0.002548167,
0.015655834,
-0.03851728,
-0.0043724976,
0.028796254,
0.026791783,
-0.003592981,
-0.02312347,
0.020725965,
-0.009013568,
-0.008319208,
-0.012059578,
-0.01572134,
-0.009059422,
-0.02501003,
0.052535474,
0.05319053,
0.03204533,
0.014293318,
0.0050766827,
0.0016605664,
0.0039041326,
0.0072711194,
0.0034488689,
0.008076838,
-0.02947751,
0.025730591,
0.003959812,
0.002616948,
0.02219329,
-0.031390276,
0.014633947,
0.021629943,
-0.007290771,
-0.014070598,
0.015092486,
-0.02477421,
-0.04145193,
-0.013978891,
0.0005588445,
0.0025137765,
-0.041163705,
0.002363114,
0.0009080711,
-0.010945982,
0.0098716905,
-0.006170626,
0.0340367,
-0.007009097,
0.003943436,
0.0033260458,
0.015786845,
-0.01208578,
0.00017799095,
-0.019559966,
-0.0008192292,
0.01902282,
0.006033064,
-0.0072711194,
0.016494306,
-0.02525895,
0.0063311146,
0.020883178,
-0.016232282,
-0.012865296,
-0.0019537038,
-0.04310267,
0.0015549387,
-0.014031296,
-0.02545547,
-0.015944058,
-0.026962098,
0.009000467,
-0.028167399,
0.006864985,
-0.0042545875,
0.005584351,
0.022809044,
0.0016048867,
0.0015295553,
-0.009996152,
0.03178331,
0.025141042,
0.0175948,
-0.018931113,
-0.03039459,
-0.0031590066,
-0.0013019234,
0.024499087,
0.01666462,
-0.010493994,
-0.044176962,
0.0056072776,
0.007886872,
-0.032962408,
-0.016612215,
-0.009504859,
0.0039860145,
-0.011076993,
-0.009196984,
-0.0049129184,
-0.032097735,
0.012636026,
0.0074086813,
0.017935429,
0.0019160382,
0.0047229524,
-0.021643044,
0.02055565,
0.005495918,
0.01361206,
0.012138184,
-0.01279324,
-0.017660305,
-0.021891965,
-0.012184038,
0.007841018,
-0.0032736415,
0.010592252,
-0.020162618,
0.00891531,
0.018223653,
0.012242993,
0.019664776,
0.01103114,
0.012393656,
0.041818764,
0.005034104,
0.0060985694,
-0.002911723,
0.010677409,
0.0033113072,
-0.02381783,
-0.0027430463,
0.012026825,
-0.016481204,
-0.010880477,
0.03613288,
0.010277825,
0.004306992,
0.007899973,
-0.023988143,
-0.011574836,
-0.030132568,
-0.022075381,
0.008397816,
-0.026162928,
0.001590148,
0.017712709,
0.029136881,
0.003910683,
-0.0022648554,
0.012577072,
0.015577227,
0.032831397,
-0.024106054,
0.021105899,
0.013330386,
0.011849959,
-0.018184349,
0.006501429,
0.0035864306,
-0.024748009,
-0.008286456,
-0.027066905,
-0.030420791,
-0.012629475,
0.0026824535,
0.018682191,
0.0004061346,
-0.006390069,
0.0057841428,
0.022258796,
0.020987988,
0.009007017,
-0.01548552,
-0.0122298915,
-0.024551492,
-0.0067798276,
0.001194658,
-0.021223808,
-0.0024777486,
-0.012832543,
0.0026857287,
0.0028134647,
-0.021760954,
-0.02722412,
-0.00035761952,
-0.00219935,
-0.011784454,
0.014686351,
0.0030279953,
0.004719677,
-0.01830226,
-0.010120613,
0.0065636593,
-0.015367609,
-0.03534681,
0.006596412,
0.0067208726,
0.008168546,
-0.006019963,
0.0234903,
-0.022874549,
-0.039381955,
-0.017686507,
0.02924169,
-0.020201921,
0.043364692,
0.018105742,
0.005800519,
-0.03086623,
-0.0021240185,
-0.073104225,
-0.02688349,
0.01560343,
0.012380554,
0.0011905639,
0.002721757,
0.0028151022,
-0.004041694,
-0.016861137,
0.0088236015,
-0.002517052,
-0.033381645,
0.028927265,
-0.0038189753,
0.008463321,
0.0211321,
-0.039984606,
-0.007886872,
0.017424485,
0.0035995317,
-0.011601038,
0.014005093,
0.011240758,
0.046770982,
0.0043724976,
0.03484897,
0.00668812,
0.013690666,
0.02971333,
-0.020974888,
-0.010199219,
0.018158147,
-0.008764647,
-0.0035110991,
-0.006629165,
0.0003027586,
-0.0015066284,
-0.0097406795,
0.003534026,
-0.026280839,
0.009616219,
-0.004975149,
0.01056605,
-0.013677565,
0.012858746,
0.022167088,
0.013978891,
-0.0032507144,
-0.014542239,
0.015302104,
0.0077296584,
-0.025900906,
0.006573485,
-0.010120613,
0.009196984,
0.0030378213,
-0.017188665,
-0.02312347,
-0.017005248,
-0.006976344,
-0.01983509,
-0.007605198,
0.025914008,
-0.0010259812,
-0.017516192,
-0.009131478,
0.002975591,
-0.015302104,
-0.027486142,
-0.007087704,
-0.015917856,
-0.014633947,
0.001117689,
-0.007736209,
-0.015289002,
-0.013507251,
0.011037691,
0.0043037166,
0.00627871,
0.013991992,
0.20270047,
-0.014149206,
0.02206228,
0.024223963,
0.014044397,
-0.01772581,
0.0026382373,
0.0007713282,
0.0008826877,
0.0026005716,
0.018407067,
0.0026726276,
-0.0069304905,
-0.009531062,
0.026451154,
-0.02372612,
-0.008201298,
-0.0012102156,
-0.01902282,
-0.02381783,
0.0027905377,
-0.017332777,
0.0046083177,
-0.0053976597,
0.024119155,
-0.0011987521,
-0.012308499,
0.015289002,
0.013638262,
0.010042005,
-0.024354976,
0.019546865,
0.001231505,
0.013127319,
0.0014976213,
-0.010513646,
0.009065973,
-0.01889181,
0.00073489075,
-0.015826149,
0.00078401994,
0.011345566,
-0.015367609,
0.0015549387,
-0.0065898616,
0.019992303,
0.0008679489,
0.0026955546,
0.01806644,
0.0014877955,
-0.03416771,
0.0013698854,
0.002089628,
0.008771197,
0.009282141,
-0.018669091,
0.010887028,
0.041058898,
0.027538545,
0.013874082,
0.0018603585,
0.009681725,
-0.02031983,
0.032464564,
-0.017306574,
0.01735898,
0.0035110991,
-0.003792773,
0.035373013,
-0.0096031185,
0.00020439787,
0.0024220687,
-0.0062754345,
0.011090095,
-0.010598803,
-0.037285775,
0.05151359,
0.0005129906,
0.017765114,
0.021774055,
0.015537923,
0.009380399,
-0.031757105,
0.022638729,
-0.0139264865,
-0.032647982,
0.039512966,
0.007546243,
-0.04215939,
-0.0063212886,
0.0076117483,
0.0035962563,
-0.0035733294,
-0.012806341,
0.0023107093,
0.01372997,
0.0009940472,
0.0065833107,
0.0043724976,
-0.007841018,
-0.024184661,
0.077611014,
0.0052994015,
0.0069304905,
-0.011679645,
0.02077837,
0.012406757,
0.0015115413,
-0.020686662,
0.0048506884,
0.019311044,
-0.026791783,
0.003638835,
-0.016166776,
0.01092633,
0.03649971,
0.009046321,
-0.037416786,
0.03322443,
0.0013485962,
-0.0050897836,
-0.006255783,
0.012629475,
0.0164288,
-0.0032408885,
0.0093935,
0.008443669,
0.0032195994,
-0.033512656,
-0.017621001,
-0.0059970357,
0.0027741613,
-0.0031459054,
-0.0038320764,
0.0075200405,
0.0017146085,
0.0013608785,
-0.005761216,
-0.007559344,
0.004637795,
-0.013834778,
-0.005974109,
0.0029362876,
-0.0025841952,
0.00951141,
0.008836702,
0.02008401,
0.016153676,
0.0042938907,
-0.021878865,
-0.021682346,
-0.020346032,
0.010605354,
-0.014149206,
0.025036233,
-0.022140887,
-0.006799479,
-0.008843253,
0.0036912395,
0.009360747,
-0.0115682855,
0.023975043,
-0.006760176,
-0.0008261891,
-0.009786534,
-0.02123691,
-0.16360673,
0.00810304,
0.028246006,
-0.037259575,
0.033460252,
-0.0039467113,
0.0054271375,
-0.013219026,
-0.0037993237,
-0.0068256813,
0.028508028,
0.010795319,
-0.03723337,
-0.013173172,
-0.0052404464,
0.018669091,
-0.01610127,
0.05471026,
0.022494616,
0.012432959,
0.023935739,
-0.009642421,
0.014463632,
-0.0015254612,
0.0061771763,
-0.022678033,
0.0045526377,
-0.028796254,
-0.02947751,
-0.039748788,
-0.012839094,
0.008391265,
0.025167244,
-0.006517805,
-0.008666389,
-0.007375928,
-0.0016155314,
-0.014817363,
-0.00010097071,
0.025782997,
0.030368388,
0.016179878,
-0.004575565,
0.004408526,
0.0055974517,
0.037967034,
-0.010179567,
-0.019887494,
0.0071335575,
-0.011201454,
0.018105742,
-0.0014001818,
-0.010873926,
0.021105899,
0.010251624,
0.022350503,
0.023555806,
-0.012413307,
0.0031524561,
0.0031721077,
-0.0074807373,
0.0028904337,
0.029529916,
-0.015537923,
-0.004916194,
-0.025403064,
0.008181647,
0.0011291525,
-0.017267272,
0.011358667,
-0.030027758,
-0.0004998895,
-0.006773277,
-0.026438052,
0.029975353,
0.0028101895,
-0.003403015,
-0.003982739,
0.0023287234,
-0.013186273,
-0.0328838,
0.030001557,
-0.023699919,
-0.016219182,
-0.031285465,
0.0140574975,
0.0071204565,
-0.000015544781,
-0.022232594,
-0.021145202,
0.014411228,
-0.019677876,
-0.005662957,
0.0018243304,
0.025966411,
0.018223653,
-0.011522432,
-0.014149206,
-0.020293629,
0.011646892,
0.026464254,
0.00049538596,
-0.007926175,
0.019350348,
0.050675116,
-0.010480893,
-0.025717491,
0.013716868,
0.06414306,
-0.008849804,
-0.023673717,
0.0062033786,
0.0038091494,
0.006956693,
0.008502624,
0.04703301,
-0.01090668,
0.006537457,
0.006819131,
-0.020791471,
0.058902618,
-0.007087704,
0.007854119,
0.035504024,
-0.007827917,
0.012144734,
-0.13101116,
-0.012216791,
0.023516504,
0.024394277,
-0.002030673,
0.018171247,
0.00090643344,
0.023372391,
-0.0115682855,
0.03178331,
-0.005237171,
-0.03099724,
0.0115682855,
-0.018996619,
0.027066905,
-0.0030820374,
-0.017044552,
-0.005093059,
-0.02381783,
0.0351896,
0.01455534,
0.0026611642,
-0.01443743,
-0.0164419,
0.0056367554,
0.02372612,
-0.055705946,
0.039146136,
0.02992295,
0.04519885,
0.009236286,
-0.02381783,
0.025966411,
0.010461241,
-0.010854275,
-0.0022910577,
0.010782219,
-0.023988143,
0.028114995,
-0.026909692,
-0.0073431754,
-0.009334546,
0.01549862,
0.0044773063,
0.011718948,
-0.009845489,
-0.028193602,
0.004873615,
0.019009719,
-0.018276056,
-0.047137816,
-0.03390569,
-0.025730591,
-0.0061804517,
0.0076314,
-0.029136881,
0.012315049,
0.0017571872,
0.0023794903,
-0.0063835187,
-0.004601767,
-0.0075986474,
-0.016887339,
-0.017516192,
0.022520818,
-0.017057654,
-0.023739222,
-0.03015877,
0.02218019,
-0.01349415,
-0.020634258,
-0.0018554456,
-0.020817673,
-0.0021322067,
-0.018878708,
-0.010179567,
0.00033776314,
-0.008469871,
-0.010336781,
-0.001112776,
-0.009269039,
-0.022402909,
0.01069051,
-0.013808576,
0.014869766,
0.0048899916,
0.013330386,
-0.010493994,
0.0014100076,
-0.021695448,
0.0039008574,
0.033538856,
-0.019546865,
-0.008515726,
0.004251312,
0.00080326217,
-0.008011333,
0.004588666,
0.024315672,
0.034089103,
-0.0019275018,
-0.01855118,
-0.054029003,
0.01325833,
0.028062591,
0.0014730567,
0.0063147377,
-0.022874549,
-0.00015270988,
0.004755705,
-0.0059086033,
-0.0033899138,
-0.018262956,
0.012714633,
-0.026739378,
0.016363295,
-0.030944835,
-0.014476733,
0.041844964,
-0.006645541,
0.015406912,
0.029451309,
0.0012601636,
-0.0071990634,
0.0015876915,
-0.011260409,
0.009570365,
-0.0069894455,
0.0041727056,
0.030211173,
-0.016389497,
-0.018721495,
-0.0050013512,
-0.041609146,
-0.027748164,
0.012970105,
-0.006527631,
-0.015171092,
0.015930956,
0.027957782,
0.01806644,
0.030132568,
0.000067859684,
-0.02182646,
0.015066284,
0.0072711194,
-0.007932725,
0.0047131265,
-0.0164419,
0.025638884,
0.0028085518,
-0.012970105,
0.037049957,
0.014502935,
-0.008063737,
-0.01080187,
-0.013081464,
-0.01150933,
-0.0069435914,
0.0066946703,
-0.0023156223,
-0.021210708,
0.019651674,
0.0024417206,
0.010467792,
0.0061476985,
-0.042316604,
-0.019573068,
-0.028691445,
0.0031213409,
0.008856354,
-0.023175875,
-0.020725965,
0.015472418,
0.015551025,
0.008712242,
0.009531062,
-0.010120613,
-0.010769118,
0.0053583565,
0.0012454248,
0.01725417,
0.012242993,
0.011961319,
-0.024826614,
0.010900129,
0.032464564,
-0.01185651,
-0.015983362,
0.03560883,
-0.01560343,
-0.003534026,
0.005528671,
0.008109591,
0.008653287,
0.0037993237,
0.003180296,
0.013651363,
-0.02511484,
0.024525288,
-0.0017571872,
0.020031607,
0.0096031185,
-0.0023794903,
0.018918011,
-0.03804564,
-0.026962098,
0.005623654,
-0.004457655,
-0.0364211,
-0.017987832,
0.007009097,
0.0008118598,
0.00868604,
-0.019297944,
-0.004529711,
-0.016730126,
0.007664153,
-0.022678033,
-0.016520508,
-0.0026742653,
0.03566124,
0.020581853,
-0.002929737,
0.008980815,
0.007677254,
-0.0004397062,
-0.0053354297,
0.019992303,
-0.010120613,
0.02147273,
0.0036290092,
0.011679645,
0.0164419,
-0.026634568,
-0.016035765,
-0.0012519754,
-0.015786845,
-0.0052306205,
0.0040908237,
-0.017686507,
0.07420472,
0.00727767,
-0.013978891,
0.00017860506,
-0.038229056,
0.0045919414,
0.001767013,
0.020791471,
-0.03063041,
-0.02853423,
0.027748164,
-0.018118843,
0.015786845,
-0.033276834,
-0.010461241,
0.0076117483,
-0.02185266,
0.0019553415,
-0.016507406,
-0.0050046262,
-0.0022615802,
-0.0120923305,
0.010251624,
0.0124853635,
-0.020411538,
-0.0062361313,
0.023175875,
-0.021118999,
0.009413152,
-0.02371302,
0.007336625,
0.01384788,
-0.02396194,
0.005119261,
-0.0060756425,
0.0077886134,
-0.011240758,
-0.020608056,
0.017267272,
0.023922637,
-0.0034488689,
0.0008270079,
-0.019193135,
-0.016363295,
-0.02017572,
-0.01502698,
-0.008345411,
-0.0148435645,
0.0035209248
] |
Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTP) that endures for more than an hour requires both transcription and translation. The signal-transduction mechanisms that couple synaptic events to protein translational machinery during long-lasting synaptic plasticity, however, are not well understood. One signaling pathway that is stimulated by growth factors and results in the translation of specific mRNAs includes the rapamycin-sensitive kinase mammalian target of rapamycin (mTOR, also known as FRAP and RAFT-1). Several components of this translational signaling pathway, including | [
-0.025856601,
-0.023261674,
0.015132666,
-0.037335183,
-0.0053950665,
0.005113729,
-0.011419006,
0.01987238,
-0.02151407,
-0.028756035,
0.032224767,
0.024373785,
-0.010512105,
-0.001630932,
-0.0010483972,
-0.010644499,
0.036170114,
0.0049349964,
-0.00020986561,
0.017211255,
-0.0014935728,
0.0068778824,
0.0007757477,
-0.027193783,
0.01779379,
0.019130973,
0.010128162,
-0.03950645,
-0.016138861,
-0.008380557,
0.0120478785,
0.0010426049,
-0.011154218,
0.01016788,
-0.0037732366,
-0.0073081637,
0.0005697091,
-0.017727593,
0.002474118,
-0.016046185,
0.007281685,
0.012292808,
0.0031741527,
-0.018349847,
0.009578725,
-0.008459994,
0.0049614753,
-0.0068050656,
0.00018969616,
0.024863644,
0.020190127,
0.022507027,
-0.026876038,
-0.009962669,
0.0047264756,
-0.013927877,
0.014245624,
0.0374411,
0.036143634,
-0.0032105611,
-0.003604434,
0.012895202,
-0.023195477,
0.012590695,
-0.0068977415,
0.028014628,
0.004554363,
0.011412386,
0.009088866,
0.0009151754,
0.018972099,
0.021130126,
-0.0038195748,
-0.009095486,
0.020905055,
-0.02263942,
-0.006606474,
-0.0063449955,
-0.016986186,
0.016046185,
0.015635764,
-0.02150083,
0.0061629536,
0.02727322,
-0.011299851,
-0.023844209,
-0.001258573,
0.01594027,
0.0061563337,
0.012411963,
0.012491399,
0.02564477,
0.018151255,
0.02220252,
0.0075464733,
-0.009267599,
-0.0063218265,
0.024148716,
-0.018892663,
-0.011498443,
-0.018985339,
0.010214218,
0.0057194326,
-0.01734365,
-0.018852944,
0.009492669,
0.0031245048,
0.01016788,
0.019806184,
-0.020375479,
-0.036938,
0.043637153,
-0.009320557,
-0.021421393,
0.011875766,
0.004064504,
0.028014628,
0.0041935886,
0.0053652776,
-0.022268716,
0.031536315,
0.02516815,
0.018747028,
-0.0008613902,
0.029418007,
0.01617858,
0.008142248,
0.010439288,
-0.029921105,
0.016946467,
0.005593658,
-0.0012213371,
-0.010988724,
0.003816265,
-0.02703491,
0.02101097,
-0.0047728135,
-0.027140826,
-0.016972946,
-0.01895886,
-0.0003322269,
0.00808267,
-0.025274066,
0.0011154218,
-0.017211255,
0.01686703,
-0.0014290307,
0.0012453336,
0.012517879,
-0.0044484474,
0.016787594,
-0.011994921,
-0.0007062407,
0.007559713,
-0.0022010547,
0.011610977,
-0.0061596436,
0.013464497,
-0.0057988693,
0.0027322867,
0.014510412,
0.0004728958,
0.008929994,
0.020282803,
0.018654352,
0.010876189,
0.011968442,
-0.010128162,
0.023394069,
-0.0032089062,
0.00016714777,
0.0077914027,
-0.033072088,
0.038818,
-0.015225342,
0.0039420393,
0.0051699965,
-0.0033545399,
-0.027193783,
-0.008062812,
0.0017873227,
-0.012762808,
0.0019164071,
0.01040619,
-0.012630413,
-0.013954356,
0.016496327,
-0.009340416,
0.00035746454,
-0.0029888006,
-0.0033892933,
0.014152948,
0.0008208445,
-0.018654352,
-0.63803446,
-0.015503369,
0.024784207,
-0.015198862,
0.007559713,
0.02405604,
-0.011306471,
0.001479506,
-0.02957688,
0.047344193,
-0.028623642,
0.025565334,
0.012888582,
-0.033919413,
-0.020004775,
-0.02262618,
-0.011147598,
-0.021686181,
0.024108997,
0.017886465,
-0.019965056,
-0.0074802763,
0.01456337,
0.02865012,
0.018111536,
0.0041671097,
0.01780703,
-0.02727322,
-0.008301121,
0.04181011,
-0.037096877,
0.018243931,
-0.010114922,
-0.004322673,
0.04599377,
0.00785098,
0.0009747528,
0.03513744,
0.020084212,
0.025075475,
-0.029418007,
-0.00763253,
0.014881116,
0.019395761,
-0.020031253,
-0.0007078956,
0.0038195748,
0.0036772508,
-0.020494632,
-0.030212373,
0.009678021,
0.01620506,
-0.030662514,
0.010009007,
0.006096756,
0.020150408,
0.017965904,
-0.009896472,
0.007553093,
0.017383369,
0.0053421087,
0.0088637965,
-0.023513222,
-0.001511777,
0.004458377,
-0.017145058,
-0.018296888,
0.0030367936,
0.01016126,
0.016986186,
0.020269563,
0.024996039,
0.007447178,
-0.020203365,
-0.006444291,
0.028597163,
-0.005361968,
0.007910558,
0.00027202885,
0.0055572498,
0.0017294001,
-0.005517531,
-0.03924166,
-0.018283648,
0.014947313,
0.009327176,
-0.014867877,
0.012855484,
0.019329563,
-0.015344496,
-0.0074008396,
-0.010902668,
-0.031165611,
-0.05899489,
-0.03166871,
0.011802949,
0.0049349964,
0.019554634,
0.0031526387,
-0.021328717,
-0.0180321,
0.008003234,
0.002035562,
0.0024029561,
0.015503369,
-0.01294816,
-0.031112654,
0.0150532285,
0.056558833,
-0.00900943,
0.009313937,
-0.005732672,
-0.004941616,
-0.009644923,
0.0007989167,
-0.020415196,
0.021408154,
-0.011889006,
0.007678868,
-0.015596045,
0.0077914027,
0.013418159,
0.014139708,
-0.0005316457,
0.014126468,
0.022454068,
-0.0017078861,
-0.012723089,
0.005067391,
0.022930687,
0.012491399,
0.0013893124,
0.036779128,
-0.014947313,
0.016138861,
0.016337452,
0.027935192,
0.007976755,
0.025048995,
-0.04273687,
-0.019514916,
0.009724359,
-0.0033148215,
-0.02265266,
-0.012643653,
-0.018998578,
-0.024439983,
-0.0029970754,
0.005914714,
-0.015370975,
-0.0042597856,
-0.00508063,
-0.007844361,
0.005689644,
0.016085904,
-0.013848441,
-0.013484357,
-0.028808994,
-0.011882386,
-0.018521959,
-0.0068315445,
0.010485627,
-0.036170114,
0.021328717,
-0.020428436,
-0.023486745,
0.0088174585,
0.020097451,
0.015569567,
-0.02912674,
0.0080230925,
-0.03587885,
-0.01689351,
0.006381404,
-0.017250974,
0.022983646,
0.014430976,
0.01780703,
0.013305624,
-0.010234077,
-0.01409999,
-0.004014856,
-0.017701114,
0.0035481665,
0.034051806,
0.0314304,
0.024532659,
0.0020901745,
0.0039188704,
0.023632377,
-0.024850404,
0.022546744,
-0.017740833,
0.017886465,
-0.0012114076,
-0.02704815,
-0.0038758423,
0.010968866,
0.000037106598,
0.021275759,
0.012160414,
-0.035349272,
0.011021823,
-0.014894356,
-0.00091186556,
-0.01779379,
-0.007817882,
-0.02262618,
-0.008056192,
0.006523728,
-0.009644923,
0.0076590087,
0.00011522439,
-0.01805858,
-0.006771967,
0.010882809,
0.016562523,
0.023950124,
-0.028067585,
-0.020441676,
0.008625487,
-0.03145688,
0.023923645,
-0.012901822,
0.01201478,
0.033919413,
-0.0024691531,
0.027882233,
-0.00093337963,
-0.025975756,
-0.012074358,
-0.006070277,
0.0014232384,
0.024148716,
0.010485627,
-0.0008415311,
-0.003328061,
-0.008559289,
0.0393211,
0.006543587,
0.022573223,
0.006649502,
-0.0074008396,
-0.0068315445,
0.006520418,
-0.00075340614,
0.028808994,
0.018932382,
-0.014973792,
0.014272102,
-0.0143383,
0.03217181,
-0.015688721,
0.007606051,
-0.002260632,
-0.005113729,
0.016708158,
0.013020976,
0.04300166,
0.034766737,
-0.0070830937,
0.026425896,
-0.0047297855,
-0.008254783,
-0.0123987235,
0.021236042,
0.01758196,
-0.0021530618,
-0.013570413,
-0.0037268987,
-0.021898013,
-0.0047330954,
0.008850557,
-0.019965056,
0.025790405,
-0.010611401,
0.0066958405,
0.01915745,
0.00415718,
-0.0010732211,
-0.01155802,
-0.02471801,
0.034343075,
0.009850134,
-0.008896895,
-0.017118579,
-0.03791772,
-0.0028233079,
-0.016337452,
-0.009777317,
-0.0014042067,
0.0047661937,
-0.0018518649,
-0.004987954,
-0.010359852,
-0.029232655,
0.032701384,
-0.0021447872,
0.019845901,
-0.020269563,
0.014285342,
0.01595351,
-0.017529001,
-0.009552247,
0.033336878,
-0.005385137,
-0.009433092,
-0.022361392,
-0.0052494328,
-0.016774355,
-0.000821672,
-0.00021782995,
0.003263519,
-0.056347,
0.029100262,
0.00019176483,
0.004994574,
0.009287458,
0.02079914,
0.005179926,
-0.016218299,
-0.020944774,
0.0013860025,
-0.0013189779,
0.043584194,
0.023645617,
0.0062357704,
0.0057028835,
-0.020004775,
0.0064145024,
-0.010088444,
-0.0120015405,
0.018455762,
-0.025538854,
-0.0048191515,
0.006513798,
0.014536891,
0.002793519,
0.008824078,
0.0051666866,
0.0062754885,
-0.017264213,
0.012782667,
-0.029841669,
0.038818,
-0.006550207,
0.018694071,
0.03421068,
0.021792097,
-0.019792944,
0.018336607,
0.027405614,
0.007897318,
-0.021845056,
0.013054076,
0.008440135,
0.006450911,
0.013418159,
-0.015092947,
-0.02450618,
0.011849287,
0.014775201,
0.007076474,
0.03471378,
0.017277453,
0.009433092,
0.029418007,
-0.0015374285,
0.000041605934,
-0.022758575,
-0.016522804,
0.030874344,
-0.02263942,
-0.0068911216,
0.023248434,
-0.016430128,
-0.021236042,
-0.008982952,
0.010333373,
-0.02057407,
0.0097045,
-0.0071757697,
-0.0023880617,
-0.017926184,
-0.026452376,
-0.011498443,
0.0064376714,
-0.01317323,
-0.0010426049,
-0.004491476,
0.0021861603,
-0.0026180968,
-0.015768157,
-0.0007153428,
-0.018151255,
-0.035746455,
-0.033945892,
0.0011791365,
0.017701114,
0.020375479,
0.009869993,
-0.015675481,
-0.021183083,
0.030000541,
-0.035031524,
-0.017025903,
-0.021924492,
-0.038208988,
-0.006172883,
-0.00055853836,
0.020706464,
-0.028385332,
-0.0069705583,
-0.010723936,
0.033416316,
-0.011286612,
0.026518572,
-0.01225309,
-0.027299698,
-0.0052328836,
0.02079914,
0.028279416,
0.029550401,
-0.007182389,
-0.0053487285,
-0.042869266,
-0.026558291,
-0.033098567,
-0.012451681,
0.0027389065,
0.0135505535,
-0.0011692069,
-0.010823232,
-0.020627027,
0.010022246,
-0.0035978144,
-0.01432506,
0.017965904,
0.025565334,
0.021580266,
0.0028034488,
0.013378441,
0.010677598,
0.0057492214,
-0.00762591,
-0.021593506,
0.022573223,
0.0066428827,
-0.014457455,
-0.006513798,
0.00925436,
0.004597391,
-0.015834356,
0.007738445,
-0.008916754,
0.059206717,
0.003283378,
-0.016787594,
-0.01640365,
0.00018400735,
-0.03002702,
-0.007447178,
-0.004021476,
-0.0018220762,
-0.02030928,
0.001363661,
0.007553093,
0.007817882,
0.018588156,
-0.03714983,
-0.016218299,
0.015066468,
0.012061118,
0.010220838,
0.00065121433,
0.01595351,
-0.043557715,
-0.012683371,
-0.008162107,
-0.03354871,
0.00646746,
-0.019289846,
0.022387872,
0.0015142595,
0.044272646,
0.0043623913,
-0.0101745,
0.01779379,
0.010909288,
-0.009664781,
-0.0068249246,
0.0056267567,
-0.02772336,
0.045384757,
0.0154504115,
0.000095261814,
0.037043918,
-0.015159144,
0.011564639,
0.023380829,
0.0035051384,
-0.022943927,
-0.001663203,
-0.020971254,
-0.02286449,
0.012504639,
-0.0074074594,
-0.007420699,
-0.008175346,
0.0019958436,
0.014709003,
0.006123235,
0.004554363,
-0.013570413,
0.025115194,
-0.028782515,
0.018363085,
-0.0067852065,
0.008638727,
-0.015000271,
-0.017965904,
-0.02287773,
0.006583305,
0.008062812,
-0.00046875846,
0.0037136592,
0.0023301393,
0.014709003,
-0.00810253,
-0.0121339355,
-0.02822646,
-0.0133718215,
-0.028703079,
-0.030794907,
-0.0016963016,
-0.0069440794,
-0.0374411,
-0.041254055,
0.012180273,
0.005024363,
-0.018442523,
0.03214533,
-0.010545203,
-0.01731717,
0.054917146,
-0.021183083,
0.030397724,
-0.019369282,
0.011134358,
0.03259547,
0.012325907,
-0.014457455,
-0.019342802,
0.0016590657,
0.00007529924,
0.027538009,
0.021103647,
-0.018601395,
-0.005520841,
0.004690067,
0.017621677,
-0.01872055,
-0.04575546,
0.030397724,
-0.01756872,
0.006212601,
-0.007996614,
0.00992957,
-0.025472658,
0.004514645,
-0.009274219,
0.0012660202,
0.014523651,
-0.023063082,
-0.016430128,
0.011677175,
0.009141824,
0.0072883046,
0.005428165,
-0.014947313,
-0.007903938,
-0.0010310204,
0.0071559106,
-0.008234924,
-0.006172883,
0.046179123,
0.025724206,
0.010750415,
0.008724783,
0.02036224,
0.012292808,
-0.02220252,
-0.008294501,
0.043134052,
-0.010253936,
-0.01110126,
0.023764772,
0.002262287,
-0.020176888,
-0.016218299,
-0.008056192,
-0.014973792,
-0.031774625,
-0.0019379212,
0.020401957,
0.01502675,
-0.012802526,
-0.012723089,
-0.010346612,
-0.009512529,
-0.0038758423,
-0.0023648927,
0.03323096,
-0.04572898,
-0.013510835,
-0.002609822,
0.0240428,
0.033892933,
0.007652389,
-0.0023185548,
-0.018972099,
0.024638575,
-0.030556599,
0.014642807,
0.02287773,
-0.011538161,
-0.009194782,
0.0046801376,
-0.013040836,
-0.0004021476,
0.016125623,
-0.012584075,
-0.020891815,
0.033628143,
0.016734635,
0.024665052,
0.0061364747,
-0.01616534,
0.01223985,
-0.017224494,
-0.0068249246,
0.005891545,
0.011147598,
-0.009353655,
-0.0114256255,
0.012716469,
0.020653507,
-0.02703491,
-0.025101954,
0.005623447,
-0.008989571,
0.0030930613,
-0.0054447143,
0.017965904,
-0.004186969,
-0.023288153,
-0.022281956,
0.004458377,
0.012670131,
-0.014589849,
-0.020137168,
0.014020554,
-0.004600701,
0.0018071819,
-0.011213795,
0.013391681,
0.014867877,
-0.0133718215,
-0.008446755,
0.00088207686,
0.0065965448,
-0.018243931,
-0.024267871,
-0.008559289,
-0.02822646,
0.042816307,
0.0026230614,
-0.031139133,
0.010326753,
-0.007539854,
-0.05128954,
-0.016681679,
0.010690837,
-0.005431475,
0.009843514,
0.011392527,
-0.016046185,
-0.002589963,
0.0052428134,
0.014854637,
0.012881963,
0.007102953,
-0.0059279534,
-0.0053487285,
0.010737175,
0.02335435,
-0.033125047,
-0.012279569,
0.056982495,
-0.04461687,
-0.0043359124,
0.010598161,
-0.030291809,
-0.014854637,
-0.007003657,
0.005656545,
-0.0034190821,
0.021831816,
0.026452376,
-0.021659702,
0.012537737,
0.014907595,
-0.0072618257,
-0.04763546,
0.0024774277,
-0.008651965,
0.027617445,
0.0146957645,
-0.016284496,
-0.013351962,
0.03399885,
-0.0131070325,
0.04485518,
0.014709003,
0.01985914,
-0.004534504,
0.020600548,
-0.023221955,
-0.023447026,
-0.00807605,
-0.0085990075,
0.00037690994,
0.016972946,
0.008268022,
0.006639573,
0.014497173,
-0.0047562644,
-0.020256324,
-0.01523858,
0.0002230016,
-0.0024923221,
-0.03466082,
0.00074968254,
0.008612247,
-0.027299698,
-0.021156605,
0.0053752074,
-0.0072485865,
-0.008883656,
-0.013570413,
-0.004574222,
-0.019316325,
0.0041671097,
-0.002035562,
-0.019117733,
-0.004484856,
-0.033839975,
-0.007692107,
-0.03188054,
0.018085057,
0.18047987,
-0.02774984,
-0.016443368,
0.0038228845,
0.0021166534,
0.020349,
0.02774984,
-0.008797599,
-0.012696611,
-0.00094248174,
0.009684641,
0.016019708,
-0.019448718,
-0.009505909,
-0.007996614,
0.0007910558,
-0.01966055,
0.011862527,
-0.014550131,
0.0027686951,
0.014444215,
-0.002750491,
0.019713508,
0.0026693996,
0.024784207,
0.011617597,
-0.019038295,
-0.012835625,
0.0016102453,
-0.005133588,
-0.025578573,
0.0029854907,
-0.0042498563,
0.016258016,
-0.0047661937,
0.0038526733,
0.01341154,
-0.016509566,
0.03074195,
0.0004460032,
0.026399419,
0.023698574,
0.007116192,
-0.025141671,
0.00012577456,
0.011200556,
-0.013663089,
-0.021130126,
-0.0061828126,
0.0003326406,
-0.033654623,
0.0021232732,
0.013451258,
0.026981952,
0.009452951,
-0.00393211,
-0.006086827,
0.02637294,
-0.006086827,
0.026386179,
-0.039082788,
-0.010035486,
-0.031959977,
0.009797176,
-0.01595351,
0.020097451,
-0.010022246,
0.0046073208,
0.028491247,
-0.016284496,
-0.02287773,
-0.009366895,
-0.005434785,
0.011352809,
-0.016814072,
-0.0074537974,
0.012650273,
0.009433092,
0.011279992,
0.025684489,
-0.0077053467,
-0.008559289,
-0.025843361,
0.0028249628,
0.008963092,
-0.01917069,
0.024360547,
0.001527499,
-0.0005841897,
0.02241435,
0.022281956,
-0.012306048,
-0.01620506,
0.0064343615,
0.010770274,
-0.023473505,
0.0036375327,
-0.01225971,
-0.015225342,
-0.025697729,
-0.021990689,
0.063919954,
0.03466082,
0.019978296,
-0.011855907,
-0.003278413,
0.00003410704,
0.028941387,
0.0029242586,
-0.02147435,
0.0023913716,
-0.024916602,
0.011233654,
-0.026862798,
-0.017634917,
-0.016946467,
0.016350692,
-0.01849548,
0.04805912,
-0.0019726746,
-0.013782243,
-0.0254197,
0.0032519342,
-0.004537814,
0.0035283074,
0.00040628493,
0.00027202885,
-0.02105069,
-0.013596891,
-0.029259134,
0.018998578,
0.0009499289,
-0.0142985815,
-0.0015109496,
-0.008691684,
-0.016483087,
0.0028051035,
-0.007579572,
-0.00924112,
0.019448718,
-0.017621677,
-0.0048323907,
0.0001569079,
0.01778055,
0.008546051,
-0.006745488,
-0.015410693,
0.017899705,
-0.002311935,
0.010545203,
0.0066892207,
0.0037533776,
0.005057461,
0.0019147522,
0.00554732,
-0.015119426,
-0.022586463,
-0.03444899,
-0.0099692885,
-0.00056805415,
-0.03370758,
-0.010214218,
0.0061993618,
0.0023748223,
0.00020872784,
0.0029937655,
-0.1662872,
-0.0021547168,
0.0043392223,
-0.01733041,
0.012809146,
0.0074537974,
0.03378702,
0.008883656,
-0.014457455,
0.028438289,
0.0058220383,
0.015609285,
-0.010293655,
-0.029841669,
0.007903938,
0.0067322487,
0.009625063,
0.023645617,
0.0008920064,
0.0020819,
0.011385907,
-0.04668222,
0.02079914,
-0.0081091495,
-0.016827311,
0.006404573,
0.0036640114,
-0.028623642,
-0.006037179,
-0.024532659,
-0.016721396,
0.0116904145,
0.022599703,
-0.010267176,
0.015688721,
0.0071559106,
-0.0019776395,
0.0011692069,
-0.018574916,
0.035269834,
0.03325744,
0.024439983,
-0.005666475,
0.004134011,
-0.005679714,
0.01525182,
0.02449294,
-0.0036607017,
-0.007718586,
0.006771967,
0.021394914,
-0.013914638,
-0.023499982,
0.014033793,
0.026028713,
0.011054922,
0.010664359,
0.010518725,
0.013623371,
-0.0015018475,
-0.0314304,
-0.007069854,
0.04419321,
-0.0037103496,
-0.0047066165,
-0.03675265,
-0.01779379,
-0.009889852,
-0.023672096,
0.012167034,
-0.022917448,
0.0017955973,
0.0046106307,
-0.023036603,
0.014775201,
0.023208715,
-0.018773507,
0.007956896,
-0.000083987616,
0.0021894702,
-0.017661396,
0.020044493,
-0.015675481,
-0.014404497,
-0.0012718125,
-0.020176888,
0.023168998,
0.02105069,
-0.001051707,
-0.0062986575,
0.010776894,
-0.013583653,
0.004047955,
0.0023682024,
0.026955474,
0.0018419353,
-0.010637879,
0.014907595,
0.008407036,
0.001121214,
0.037758846,
0.0010426049,
-0.003948659,
-0.010962246,
0.02030928,
0.00461725,
-0.008446755,
0.016694918,
0.036620256,
-0.0061596436,
-0.0047496445,
0.010081824,
0.0007500963,
0.025022518,
-0.004686757,
0.007844361,
0.01178971,
0.0008969712,
0.015185623,
0.0018204212,
0.06508502,
0.009386754,
0.015079708,
0.02588308,
-0.007963516,
-0.024161955,
-0.12413287,
-0.028491247,
0.005616827,
0.032727864,
-0.01408675,
0.007043375,
0.01203464,
0.032780822,
-0.007374361,
0.031589273,
-0.019726746,
-0.013080554,
0.011180696,
-0.0028746107,
0.0010963901,
-0.020296043,
0.029073782,
-0.007519995,
-0.028305896,
0.033178005,
-0.0027620755,
0.002704153,
-0.004365701,
0.004925067,
0.00014004832,
0.009115346,
-0.027590966,
0.0127959065,
-0.00007178252,
0.0042829546,
0.01293492,
-0.023738293,
0.019356042,
-0.003304892,
-0.0071492908,
-0.023592658,
-0.007553093,
-0.009830275,
0.028438289,
0.0069904174,
-0.004991264,
-0.006096756,
0.03998307,
-0.0048621795,
-0.007745065,
-0.01203464,
-0.0049316864,
0.01778055,
0.00048034298,
-0.016138861,
-0.029100262,
-0.022083364,
-0.041227575,
-0.008850557,
0.022056885,
-0.012537737,
-0.013954356,
0.029259134,
0.0019213719,
-0.014417736,
-0.022480547,
0.006262249,
-0.011975062,
-0.011233654,
0.021818576,
-0.00739422,
-0.023010124,
-0.06709742,
0.026399419,
-0.008268022,
0.009730979,
0.020931534,
-0.014483933,
0.00013704876,
-0.041333493,
0.018773507,
-0.017449565,
-0.023539701,
0.014152948,
-0.015079708,
-0.019528154,
-0.029206177,
0.019091254,
-0.02102421,
0.0057227425,
0.013967596,
0.012584075,
-0.007698727,
0.0053454186,
-0.0056267567,
-0.0075266142,
0.004666898,
-0.006219221,
-0.007142671,
-0.016708158,
-0.009115346,
-0.0042233774,
0.0052395035,
0.032277722,
0.032489553,
-0.028385332,
-0.001919717,
-0.037758846,
0.0074802763,
0.021567026,
-0.019276606,
0.023738293,
-0.007897318,
0.0141661875,
-0.010803373,
-0.010200978,
-0.008228304,
-0.04183659,
-0.008896895,
0.008605627,
-0.019739985,
-0.029735753,
0.0080694305,
0.029020824,
-0.005656545,
0.016800834,
0.029894626,
-0.0051699965,
0.0016516185,
0.008234924,
0.026240544,
-0.012067738,
-0.014510412,
-0.021553788,
0.0052659824,
-0.014047032,
0.013821962,
-0.00508394,
-0.03217181,
0.0016723052,
0.0072618257,
-0.02706139,
-0.015370975,
-0.010028866,
0.03466082,
0.026889276,
0.048429824,
-0.010326753,
-0.027114347,
0.0017409846,
-0.03630251,
0.017396607,
-0.014775201,
-0.03839434,
-0.0028828853,
-0.0071294317,
-0.013490976,
0.009883232,
0.012292808,
-0.0026396108,
-0.007678868,
-0.022109844,
0.010035486,
-0.008493093,
-0.012087597,
-0.006563446,
-0.01363661,
0.011988302,
0.0072618257,
0.013113652,
-0.013610131,
-0.0017525692,
-0.010962246,
-0.04665574,
-0.00810253,
0.012299428,
-0.012855484,
-0.025128433,
0.011134358,
0.031986456,
0.0077583045,
0.004534504,
-0.0038990113,
-0.009883232,
-0.016562523,
-0.023857448,
0.0068778824,
0.005918024,
-0.0033379905,
-0.0051898556,
0.023288153,
0.010300274,
0.0023632378,
0.0058286577,
0.026981952,
-0.009717739,
-0.007255206,
0.00901605,
-0.001005369,
0.010015626,
0.014126468,
0.026876038,
0.019514916,
-0.026637727,
-0.005517531,
-0.000023065564,
0.0009913021,
0.007692107,
-0.007460417,
0.014378018,
-0.025684489,
-0.005030982,
0.03346927,
-0.049356584,
-0.044722784,
-0.003975138,
-0.0088637965,
-0.008380557,
0.0036706312,
0.0008382212,
-0.004554363,
-0.013378441,
0.02380449,
-0.0018402804,
-0.0118228085,
-0.0042829546,
0.009373514,
0.023963364,
0.003301582,
0.0006781069,
0.009856754,
0.00415718,
0.0029755612,
0.013596891,
-0.005408306,
0.020944774,
0.006454221,
0.0007674731,
0.0024195053,
-0.027379135,
-0.004418659,
-0.013471117,
-0.010426049,
-0.008890275,
0.018654352,
0.012531118,
0.072922766,
0.0074074594,
-0.0056300666,
0.007930417,
-0.0039420393,
0.036434904,
0.0016052806,
0.031377442,
-0.014351539,
-0.02933857,
0.00485556,
-0.020468155,
0.025313785,
-0.037838284,
0.0029374978,
0.0043822504,
-0.0077119665,
0.030132936,
-0.012372245,
-0.01432506,
0.016337452,
0.0026710543,
-0.00038063354,
0.007136051,
-0.017290693,
0.010015626,
0.043848984,
0.0038957014,
0.02822646,
-0.008559289,
-0.006589925,
0.0009565486,
-0.03373406,
0.0069440794,
0.009294078,
-0.0031311244,
-0.021527309,
-0.018667592,
0.016284496,
0.024996039,
0.0038791522,
-0.01341154,
-0.0029457726,
-0.024214912,
-0.004590771,
0.021421393,
0.008056192,
-0.016986186,
-0.045967292
] |
SPECIFIC AIMSOur previous studies implied the relation between lipid metabolism and amyloid beta protein (Aβ) as ‘a missing link in Alzheimer’s puzzle’ [FASEB J., vol. 12, p. 1097 (1998)]. In the present study, we evaluated the role of cholesterol in synaptic plasticity and neuronal degeneration by a combination of adult rat hippocampal slice technology, a well-established procedure for limited cholesterol efflux, lipid metabolic labeling, extracellular recording of CA1 field excitatory postsynaptic potentials (fEPSPs), and immunofluorescence. PRINCIPAL FIND | [
-0.010057011,
0.00786755,
0.017014483,
-0.03508413,
-0.034978613,
0.015550447,
-0.008639137,
0.011692512,
-0.029887456,
-0.019085238,
0.007155316,
0.018729122,
-0.00523624,
0.019072048,
-0.008375347,
-0.007834576,
0.02623396,
-0.0041052387,
-0.012312419,
0.0125959935,
-0.036508597,
0.016196733,
0.02703852,
-0.019797472,
0.015154761,
-0.0071487213,
0.0042635133,
-0.03152296,
-0.01742336,
-0.013730292,
0.022883821,
-0.009773436,
-0.012114576,
0.0029626964,
0.018689552,
-0.0137434825,
-0.007471864,
0.0026444993,
0.01821473,
-0.015405362,
-0.0123190135,
0.014218305,
-0.004992234,
-0.0012843297,
0.0040689674,
-0.004768012,
0.00094882125,
-0.008929307,
-0.011428721,
0.020562464,
0.023121232,
0.027988166,
-0.012305824,
-0.024928197,
0.0066079507,
-0.0039964253,
-0.0079730665,
0.01846533,
-0.0049097994,
-0.01682983,
0.0027137443,
-0.0140204625,
-0.026049307,
0.012450909,
-0.0038579353,
0.014178736,
0.0044151926,
0.019995315,
0.008223667,
0.01987661,
0.016407765,
0.010254853,
-0.02318718,
-0.0056352234,
0.01797732,
0.017265085,
-0.015537257,
-0.022171587,
-0.017396979,
0.026458181,
0.028120061,
-0.025297504,
-0.012088197,
0.02180228,
0.01407322,
-0.015444931,
0.008494052,
0.014930539,
0.0005778659,
-0.0047218488,
-0.00032025808,
0.016697936,
0.045160923,
0.009628351,
-0.000910077,
0.02732869,
-0.006195778,
0.02538983,
-0.014284252,
-0.00261812,
-0.00523624,
0.0007501541,
-0.024150016,
-0.016856208,
-0.0107428655,
-0.025257936,
-0.0011689214,
0.0017311248,
0.027486965,
-0.0077686287,
-0.008672111,
0.02346416,
0.0018036672,
-0.023042096,
0.010136148,
0.0062782126,
0.011369368,
0.0027137443,
-0.009212881,
-0.014112789,
0.019771094,
0.018544469,
0.03123279,
-0.011000061,
-0.007933497,
0.0005304661,
-0.003890909,
-0.0055198153,
-0.00772906,
-0.0028522343,
-0.0062551307,
0.0073861326,
0.014666748,
-0.0075971647,
-0.021327458,
0.013308228,
-0.015405362,
-0.008414915,
-0.008362157,
-0.033263974,
-0.0009892142,
0.03453017,
-0.0055923574,
0.007913713,
-0.00545057,
0.053707734,
0.012675131,
0.022026502,
0.003358382,
0.0037293374,
0.00042453775,
-0.02371476,
0.0070432047,
0.013506071,
0.020773498,
0.029280739,
0.0053813253,
0.014060031,
-0.017014483,
-0.015154761,
0.0059253927,
0.0033995993,
-0.012213497,
0.018438952,
0.025257936,
0.010446101,
-0.001019715,
-0.023081664,
0.013901756,
-0.025627242,
-0.006931094,
0.0040491833,
-0.016038459,
0.020193158,
-0.00421735,
0.01990299,
0.010531833,
0.016196733,
-0.012477288,
-0.042602155,
-0.0073201847,
0.0140204625,
0.017291464,
0.003890909,
0.006739846,
0.02846299,
0.022197966,
-0.010459291,
0.015378983,
-0.015141572,
0.017251896,
0.010815408,
-0.025046902,
-0.051808443,
-0.6482914,
-0.027539723,
0.02070755,
0.0005634399,
0.0045009246,
0.031681232,
0.0053582434,
-0.0058000926,
-0.0025521726,
0.025864653,
-0.0046361173,
0.023938984,
-0.002773097,
-0.0064167026,
-0.033712417,
-0.018702742,
-0.0013502773,
-0.024202773,
0.020272296,
-0.011633159,
-0.035796363,
0.0051373187,
-0.0056055468,
0.021393405,
0.01339396,
0.029913837,
0.030705208,
-0.031048136,
-0.009991063,
0.018201541,
-0.024413805,
0.024242342,
0.00307151,
0.008184099,
0.04977726,
0.0059550693,
-0.004949368,
0.0074125114,
0.015339415,
0.015286656,
-0.012417935,
-0.021037288,
-0.0055725733,
0.0142974425,
-0.019388597,
0.026194392,
0.0114551,
0.018636795,
-0.0060770726,
-0.009892141,
0.018834637,
0.003406194,
-0.030467797,
0.006739846,
0.013024653,
0.015036055,
0.021406595,
-0.030441416,
-0.0006462866,
0.035189644,
0.009206287,
-0.0010452697,
-0.024783112,
-0.020298675,
-0.043551803,
0.013703913,
-0.017278275,
0.012549831,
0.010861572,
-0.0077422494,
0.0006656587,
0.022290293,
-0.01792456,
-0.0079532815,
0.023437781,
-0.017449738,
0.041546997,
0.018861016,
-0.03450379,
0.0031341603,
0.002885208,
0.017146379,
-0.005190077,
-0.0012703158,
0.0025093067,
0.0013848998,
-0.019414976,
0.0098064095,
0.006739846,
0.01379624,
0.025838275,
0.005842958,
-0.001815208,
-0.051518273,
-0.018425763,
0.03173399,
-0.017172758,
0.004886718,
0.0056055468,
-0.006716764,
-0.011105577,
-0.0032396764,
0.001168097,
0.010914329,
0.022791494,
0.0130642215,
-0.015286656,
0.004428382,
0.041151308,
-0.018188352,
0.0030220493,
0.0010452697,
-0.00911396,
-0.013420339,
-0.014389769,
-0.028594885,
0.027856272,
-0.012101387,
0.0075114327,
-0.03062607,
0.030573312,
-0.011191309,
0.0002104141,
0.008045608,
-0.006228752,
0.012470693,
0.005483544,
-0.010386749,
-0.0077752233,
-0.0009908628,
0.0018959938,
0.00038352658,
0.028067304,
-0.019006101,
0.013651156,
0.012187119,
0.005302188,
-0.019137997,
-0.021630816,
-0.049803637,
0.0007270724,
0.008705084,
-0.009496456,
-0.0138094295,
-0.018056456,
-0.01159359,
-0.019968936,
0.010432912,
-0.002113621,
0.0042668106,
-0.0067860093,
0.011705701,
-0.026933005,
0.018438952,
0.022171587,
-0.015880184,
-0.011501263,
-0.007762034,
-0.015669152,
0.0089754695,
-0.0073927273,
0.024611648,
-0.0062946994,
0.0015687288,
-0.016671557,
-0.012450909,
0.012556425,
0.017185947,
-0.012734484,
-0.02483587,
0.0007489176,
-0.013506071,
-0.030494176,
-0.0021169183,
-0.0114880735,
0.011639753,
0.004678983,
-0.0015934592,
0.0044778427,
-0.016381387,
0.005770416,
0.003040185,
-0.008052203,
0.024070878,
0.044791616,
0.017225515,
0.03344863,
0.02594379,
0.001772342,
0.034319136,
0.012259661,
0.037168074,
0.0010370262,
-0.011131957,
-0.004791094,
-0.003119322,
0.00896228,
-0.004270108,
0.021037288,
0.027223174,
0.03664049,
-0.033501387,
0.014455716,
-0.008823791,
0.026972573,
-0.021683574,
0.014416148,
-0.008810601,
-0.00096695684,
0.020509707,
0.004174484,
-0.0008680354,
-0.009615161,
-0.03917288,
-0.013994083,
-0.0051669953,
0.01627587,
-0.0018135593,
-0.01105282,
-0.023305885,
-0.0034721417,
-0.0056253313,
0.009951495,
-0.0064167026,
-0.017331032,
0.016935347,
0.01791137,
0.027856272,
-0.0019520493,
-0.022237534,
0.010459291,
-0.018386194,
-0.0009282126,
0.051782064,
0.0070827734,
0.009964684,
0.018148782,
-0.014389769,
0.0142974425,
0.013354391,
0.002858829,
0.018333435,
0.0113298,
0.007841171,
-0.011659537,
-0.010459291,
0.028225578,
0.028832296,
-0.0068387673,
-0.0019652387,
-0.009845979,
0.012905948,
-0.0090809865,
0.0077422494,
-0.0016420955,
0.0014071572,
-0.0063903234,
0.011079199,
0.019375408,
0.029148843,
0.026840677,
0.004256918,
-0.032235194,
0.0100833895,
-0.0072476426,
0.010307612,
-0.005397812,
-0.0011598537,
-0.00414151,
-0.0107626505,
-0.034055345,
0.002182866,
-0.01959963,
-0.054446347,
0.014231495,
-0.0042107548,
0.018135592,
0.009305208,
0.043551803,
0.0023081664,
-0.028964192,
-0.022250723,
0.012239876,
-0.000778594,
-0.011995871,
-0.02954453,
-0.023028906,
-0.0056714946,
0.0051999693,
-0.005424191,
0.0045207087,
0.01630225,
-0.0017014483,
0.005068074,
-0.048484683,
-0.012523451,
0.025086472,
-0.01228604,
0.030705208,
-0.020470139,
-0.0052725114,
0.027486965,
-0.006845362,
-0.021380216,
0.022817874,
0.0099119255,
-0.0141919255,
0.0048504467,
0.0018382897,
-0.0058726347,
0.023965362,
0.0002854295,
0.00580339,
0.009925116,
0.01569553,
0.014337011,
-0.015814237,
0.00004129454,
0.015009676,
0.01299168,
-0.0071157473,
-0.041335963,
0.0053780274,
-0.000814453,
0.021617627,
0.026128443,
0.0014755778,
0.014376579,
0.015669152,
0.008269831,
-0.009971279,
-0.0063936207,
0.0102746375,
0.005569276,
-0.008513836,
-0.012549831,
-0.0016322033,
0.00045338983,
0.021907797,
0.010848382,
0.000202995,
-0.00689812,
0.01173208,
-0.006931094,
-0.0020295377,
-0.016473712,
0.009397535,
0.022778304,
0.007399322,
-0.0029874267,
0.010208691,
0.029491771,
0.0058891214,
-0.01904567,
-0.002715393,
0.0059122033,
0.0065815714,
0.011712296,
-0.009714083,
0.0037590137,
-0.001258775,
-0.0033303543,
0.011600185,
0.015207519,
0.019837042,
-0.0010098228,
0.015972512,
0.012523451,
-0.0060177194,
-0.010446101,
0.0032001077,
0.015801048,
0.001141718,
-0.029043328,
0.02980832,
0.0019091833,
-0.010399939,
-0.007122342,
0.008355563,
-0.007913713,
0.012444315,
-0.0050351,
0.02234305,
0.00014549692,
-0.0065749767,
-0.005190077,
0.007893929,
-0.016724315,
-0.008823791,
-0.011369368,
-0.018386194,
-0.0037755007,
-0.017396979,
0.008612758,
0.00951624,
-0.023965362,
-0.03394983,
-0.006515624,
-0.003061618,
0.025257936,
0.009872357,
-0.037062556,
0.0013511017,
0.04009615,
-0.018148782,
-0.002364222,
0.010281232,
-0.028779538,
0.0039436673,
-0.003534792,
0.010947304,
-0.046268843,
-0.00828302,
0.0048570414,
0.021103235,
-0.007425701,
0.033290353,
-0.009865763,
-0.028647643,
-0.019757904,
0.030204006,
0.026537318,
0.008454484,
-0.011217688,
-0.000979322,
-0.021881416,
0.004012912,
-0.039067365,
-0.010320801,
0.0010230123,
0.0019932666,
-0.010881356,
-0.0009949845,
-0.0056616026,
0.0039733434,
-0.013677535,
-0.006314484,
-0.0013881972,
0.02401812,
0.020377811,
-0.0077884127,
0.019190755,
0.00414151,
-0.0040491833,
0.013360986,
-0.015959322,
0.02070755,
-0.0063408627,
-0.022422187,
0.00883698,
0.007702681,
-0.021604437,
-0.010089984,
0.010564807,
-0.0027318797,
0.027803512,
-0.012338798,
-0.03642946,
-0.046031434,
-0.010690108,
-0.0073004006,
-0.022277104,
-0.0061595067,
-0.0064068106,
-0.00067060476,
-0.0010831895,
-0.027012141,
-0.012075008,
0.028251957,
-0.036271185,
-0.008368752,
0.004461356,
0.015642773,
0.016460523,
-0.002853883,
0.0076169493,
-0.049302433,
-0.008243452,
-0.0028340986,
-0.0061496147,
0.0037623113,
-0.0043987054,
0.030942619,
0.010756055,
0.030599691,
0.0078081973,
-0.012226687,
0.008573189,
0.018069645,
-0.00039383088,
0.01062416,
0.018175162,
-0.024519322,
0.02951815,
0.021419784,
-0.028331093,
0.026510939,
-0.018188352,
0.025825085,
0.018689552,
0.0075510014,
-0.019190755,
-0.004444869,
-0.008645732,
-0.028331093,
0.0004447342,
-0.0018399383,
-0.0051702927,
-0.0441849,
-0.026906624,
0.0039898306,
0.00813134,
0.0059023113,
-0.023886224,
0.040122528,
-0.04334077,
0.03315846,
0.012167335,
-0.008025824,
0.011521048,
-0.037642896,
0.0016511633,
0.0095294295,
0.013756672,
-0.009041417,
0.0019471032,
0.008461079,
-0.0014335362,
0.011092388,
0.0085072415,
-0.023015717,
0.008302804,
-0.019968936,
-0.031575717,
-0.018992912,
-0.023899414,
-0.008599568,
-0.04173165,
-0.0025109553,
0.021169184,
-0.019217134,
0.018267488,
-0.024136826,
-0.009918521,
0.0168694,
0.0013568721,
0.009199692,
-0.0254294,
0.026128443,
0.014693128,
0.006548598,
-0.04740314,
0.005846256,
-0.0055231126,
0.0036699846,
0.037695654,
0.024928197,
-0.008540216,
0.012879568,
-0.016988104,
0.032393467,
-0.0110198455,
-0.02430829,
0.010676919,
0.004817473,
-0.011125362,
-0.0020905393,
-0.0068387673,
-0.037669275,
0.008177504,
-0.02680111,
-0.01049886,
0.011066009,
-0.020747118,
-0.0041678892,
0.03674601,
0.011448505,
-0.005796795,
-0.001628906,
-0.014996487,
0.021578059,
-0.0033715717,
-0.013769861,
0.011197904,
0.022554083,
0.044053003,
-0.014613991,
-0.0012909245,
0.0076697073,
0.024730355,
0.0064232973,
-0.0051801847,
-0.009384345,
0.029439013,
-0.0020097534,
-0.0011458397,
0.029729184,
-0.0060012327,
0.016236302,
-0.024730355,
0.0059451773,
-0.03561171,
-0.019757904,
0.0059056086,
0.03009849,
-0.003315516,
-0.0254294,
-0.005546194,
-0.025468968,
0.006631032,
-0.028489368,
-0.016117597,
0.018096024,
-0.029096086,
0.0074586747,
-0.009001849,
0.013473097,
-0.0028456394,
0.002784638,
-0.000979322,
-0.014587612,
0.011811217,
-0.04334077,
0.0229102,
-0.004322866,
0.018082835,
-0.0152998455,
0.0011046225,
-0.016130786,
-0.008500647,
-0.0066673034,
-0.014244684,
-0.04117769,
-0.0020097534,
0.010815408,
0.016183544,
0.030942619,
-0.014060031,
0.01339396,
-0.020021694,
-0.0012035439,
0.010399939,
-0.002092188,
-0.005424191,
-0.028014544,
0.01879507,
0.010953899,
-0.0070563946,
-0.016592419,
0.007933497,
-0.023556486,
-0.0015044298,
-0.016447334,
-0.0089754695,
-0.005015316,
0.007999445,
-0.018966533,
-0.001509376,
0.0128070265,
-0.02205288,
-0.004174484,
-0.01879507,
0.0008132165,
-0.015286656,
-0.023305885,
0.004408598,
0.011283636,
-0.008487457,
-0.010228475,
0.0032512173,
-0.0024021417,
-0.016209923,
-0.029465392,
-0.010155932,
-0.020087643,
0.031628475,
-0.0045503853,
-0.021907797,
-0.010518644,
-0.00067266566,
-0.039858736,
-0.002357627,
-0.021090046,
0.000711822,
-0.0022504623,
0.023833467,
-0.00828302,
0.0023543297,
0.015484499,
0.007293806,
-0.0026791217,
-0.011422127,
0.022817874,
-0.027407827,
0.019678768,
0.0033995993,
-0.0026659323,
-0.010729676,
0.037484623,
-0.014429337,
-0.013664345,
0.016157165,
-0.024202773,
0.011791433,
-0.02376752,
0.020114021,
0.013176332,
-0.009601972,
0.024229152,
-0.026708782,
0.021947365,
0.004451464,
-0.007893929,
-0.009681109,
-0.0132554695,
-0.01901929,
-0.0032775963,
0.013295039,
-0.025046902,
-0.017964128,
0.004214052,
-0.0057341447,
0.0140864095,
-0.0034688443,
-0.008085177,
0.0049658553,
0.019837042,
-0.018096024,
-0.008810601,
0.013090601,
-0.015036055,
-0.0085072415,
-0.0015613097,
0.006865146,
0.009707488,
0.001985023,
0.02594379,
-0.028278336,
0.002868721,
-0.015814237,
0.012760863,
-0.025007334,
0.023807088,
0.007425701,
-0.0049032047,
-0.00210208,
-0.0011087442,
-0.010360369,
0.00011777831,
-0.008632543,
0.0026214176,
-0.01849171,
-0.012088197,
0.014772265,
-0.0129653,
-0.011158336,
-0.026313096,
-0.019494114,
-0.0100833895,
-0.0027961787,
0.18824086,
-0.032103296,
0.001910832,
-0.011389152,
0.00517359,
-0.00090677966,
0.0058627427,
0.017054053,
-0.0013436825,
0.03173399,
0.0071882894,
0.003854638,
-0.013558829,
0.0015728505,
-0.00034437017,
0.0052131587,
-0.018926965,
-0.009245855,
0.007702681,
-0.014482096,
0.014772265,
-0.008012635,
0.021090046,
-0.00048347842,
0.024097256,
0.011896949,
-0.0063639446,
-0.0053846226,
0.01601208,
0.0050120186,
-0.025337072,
0.011046225,
-0.014046841,
0.015853805,
-0.0000367864,
-0.00441849,
-0.012820216,
-0.0064562713,
0.022831064,
-0.0066244374,
0.024479752,
0.0025752543,
0.0025851463,
-0.0056978734,
-0.0065551926,
0.010545023,
-0.0077884127,
-0.009925116,
0.009278829,
0.012266256,
-0.033290353,
0.0011474885,
0.003785393,
0.028858675,
0.020232728,
-0.0011136903,
0.010452696,
0.03645584,
0.013769861,
0.028647643,
-0.016645176,
0.0070234207,
-0.0076697073,
0.03170761,
-0.002266949,
0.021855038,
-0.012741079,
-0.040650107,
0.010109769,
0.00092738826,
0.039885115,
-0.009582188,
-0.02099772,
-0.0067134667,
-0.004876826,
-0.023859845,
0.049249675,
0.021723144,
0.012081603,
0.023094853,
-0.012404745,
0.0027022033,
-0.033475008,
0.01766077,
-0.016130786,
-0.028040925,
0.03759014,
-0.00580339,
-0.018320246,
0.011079199,
0.01631544,
-0.01570872,
-0.0137434825,
0.019626008,
0.024677595,
-0.014772265,
0.0076631126,
0.0066475193,
-0.0063309707,
-0.018900584,
-0.02180228,
0.07006274,
0.01601208,
0.03445103,
-0.0043393527,
-0.024756733,
-0.026510939,
0.024084067,
-0.0045866566,
0.0061792913,
0.0018251002,
-0.04690194,
-0.012279445,
-0.0114880735,
-0.028278336,
0.02101091,
0.017700339,
0.00026276,
0.031628475,
-0.018161973,
-0.03141744,
-0.022422187,
0.010248259,
0.013413744,
0.0027137443,
-0.000499141,
-0.04386835,
-0.008665516,
-0.011850785,
-0.023648813,
-0.0025241447,
0.00030706858,
-0.015233899,
0.027223174,
-0.019560061,
-0.010538428,
0.0009422265,
0.027961787,
0.0122332815,
0.030151248,
-0.02099772,
-0.010030632,
0.00094882125,
-0.00800604,
0.02430829,
0.00039135784,
0.0043624346,
0.015313035,
-0.008414915,
-0.013499476,
-0.016341818,
-0.0012439368,
0.0016824885,
-0.0028918027,
0.009714083,
-0.03139106,
-0.010307612,
-0.04579402,
-0.03455655,
-0.0073861326,
-0.02569319,
0.009608567,
0.00675963,
-0.0005193374,
0.013690724,
0.0010584592,
-0.16650453,
0.0067200614,
0.008553405,
-0.016368197,
-0.0037458243,
0.0040096147,
0.020245917,
-0.008665516,
-0.011791433,
-0.0065189213,
0.00896228,
-0.02068117,
-0.02264641,
-0.0059913406,
0.015405362,
0.0020641603,
0.01688259,
0.01735741,
-0.0006174345,
0.002321356,
-0.004962558,
-0.030467797,
0.026919816,
-0.0104658855,
0.027988166,
0.01570872,
-0.012450909,
0.0035150077,
-0.003475439,
-0.018082835,
-0.020245917,
0.0080390135,
0.034028966,
0.025218366,
0.017568443,
0.00800604,
-0.00072913326,
-0.017159568,
-0.019784283,
0.022554083,
0.037115317,
0.05993319,
-0.013387365,
-0.0137434825,
-0.023609245,
0.015339415,
0.011817812,
-0.01632863,
-0.0034886287,
0.00035075887,
0.008184099,
-0.00800604,
-0.00080456084,
0.020536086,
0.006591464,
0.027724376,
-0.00031634246,
0.019283082,
0.010967088,
0.018874206,
-0.020615224,
-0.016711125,
0.024730355,
0.0075444067,
0.018438952,
-0.03724721,
-0.015141572,
-0.008731464,
-0.018399384,
-0.0018086132,
-0.0008944145,
-0.016486904,
0.0029692913,
-0.021090046,
0.016170355,
0.019269891,
-0.016513282,
0.009193097,
0.013967704,
0.0029049923,
0.0025834977,
-0.00511094,
-0.035769984,
-0.013413744,
-0.011758459,
0.0015530662,
0.019823851,
-0.011402342,
-0.0034457627,
-0.009555809,
0.0043294607,
-0.028568504,
0.015827427,
-0.004728444,
0.019942557,
0.028383851,
-0.0137434825,
0.011890355,
0.006664006,
0.008395131,
0.019784283,
0.0048504467,
-0.018821448,
0.013209307,
0.016763883,
0.0062221573,
-0.032393467,
0.007992851,
0.038223237,
-0.03007211,
-0.011382557,
-0.008454484,
-0.006644222,
0.02843661,
-0.0018828043,
-0.0029626964,
0.02155168,
-0.030731587,
0.027513344,
-0.021472542,
0.06346798,
-0.00013426521,
0.02980832,
0.0336069,
-0.009153528,
-0.012239876,
-0.12419254,
-0.031865887,
-0.020786688,
0.0458204,
0.005002126,
0.017581632,
-0.0019471032,
0.03231433,
-0.002703852,
0.032894667,
-0.022817874,
0.010169121,
0.00041856125,
-0.020654792,
0.0057836054,
-0.0029346687,
0.0072146687,
0.011560616,
-0.039700463,
0.029729184,
0.006548598,
-0.011474884,
0.009463483,
-0.010848382,
0.018531278,
-0.0017113405,
-0.010854977,
0.027064899,
-0.0017311248,
0.019837042,
0.022224344,
-0.019744715,
0.00939094,
0.010815408,
0.0116793215,
-0.025323883,
0.013321417,
-0.009015039,
0.034873098,
0.0012497072,
-0.005935285,
0.0076697073,
0.01656604,
-0.016645176,
-0.012549831,
-0.0046163327,
-0.01767396,
-0.024611648,
0.0071751,
-0.002405439,
-0.013097196,
-0.015286656,
-0.021050477,
0.0006565909,
0.029887456,
-0.010736271,
-0.0012035439,
0.010848382,
-0.025772326,
-0.029043328,
-0.009067796,
0.0066837906,
-0.0135324495,
-0.0028143143,
0.018953344,
-0.01821473,
-0.025811896,
-0.046031434,
0.014007272,
-0.011290231,
0.0071157473,
0.008658921,
-0.0030368874,
-0.0018316949,
-0.0326045,
0.014732696,
-0.01117812,
-0.024413805,
0.009483267,
0.0004793567,
-0.0050120186,
-0.020852635,
0.019085238,
-0.0009348074,
0.011699107,
0.004184376,
0.014495285,
0.0059649614,
-0.007280616,
-0.0063276733,
-0.012747673,
0.02566681,
0.0287004,
-0.020905392,
-0.0048504467,
-0.0016058243,
-0.0013238983,
-0.018003698,
0.020377811,
0.020417381,
-0.020074453,
-0.017608013,
-0.04167889,
0.0063936207,
-0.0019569953,
-0.012292635,
-0.0040261014,
0.0095492145,
-0.012892758,
-0.021709954,
-0.0038975037,
0.008797411,
-0.012055223,
0.016539661,
0.011131957,
0.0006330971,
-0.020588845,
-0.009964684,
0.04711297,
-0.0069047147,
0.01173208,
0.044264037,
0.014613991,
0.01957325,
0.0048570414,
0.025759136,
-0.019243512,
-0.0013164792,
-0.011059415,
0.020536086,
-0.0015679045,
-0.009476672,
0.0035842527,
-0.03727359,
-0.001841587,
0.0017608012,
-0.017476117,
-0.0094436975,
0.00814453,
0.023398213,
0.027961787,
0.030441416,
0.0054274886,
-0.023965362,
0.003699661,
-0.026260339,
-0.010182311,
-0.0073531587,
-0.035189644,
-0.00856,
0.013189523,
-0.03120641,
0.00966792,
0.018399384,
-0.0067365486,
-0.025468968,
-0.016473712,
0.024862248,
0.00086308934,
0.0010106472,
-0.015629584,
-0.016407765,
0.0042404314,
0.012193713,
0.008797411,
-0.009931711,
-0.0033501387,
-0.0029511556,
-0.014455716,
0.008454484,
0.00435584,
-0.03674601,
-0.029307118,
0.016078027,
0.017040862,
0.010333991,
-0.012371772,
-0.026405424,
-0.018043267,
-0.002474684,
-0.0120420335,
0.01216074,
0.021024099,
0.0011186363,
-0.027618859,
0.022514515,
0.0122332815,
-0.0155108785,
0.0037985824,
0.021142805,
-0.0077158706,
0.013703913,
-0.00120849,
0.015286656,
0.010802219,
0.016196733,
-0.003482034,
0.0025109553,
0.004642712,
-0.011072604,
0.0063936207,
0.0058891214,
-0.03176037,
0.0054637594,
-0.012886163,
-0.02980832,
-0.0023394914,
0.00344906,
-0.017528875,
-0.035004992,
0.0085270265,
0.0006776117,
0.010063605,
0.020285485,
-0.008454484,
0.0066343294,
-0.009344776,
0.016922157,
0.0049427734,
0.023516918,
-0.011382557,
0.003821664,
0.023319075,
0.008546811,
0.0013857242,
0.025073282,
0.013677535,
0.013492881,
0.03363328,
-0.0046460093,
0.009001849,
-0.016183544,
-0.002288382,
-0.014099599,
-0.040043388,
0.00002520693,
-0.020206347,
-0.019375408,
-0.0065123267,
0.025956979,
-0.028805917,
0.091746315,
0.00489661,
-0.0098261945,
-0.0015036055,
-0.008012635,
0.025956979,
0.0023460863,
0.002006456,
-0.009608567,
-0.017212326,
0.021485731,
-0.034028966,
0.017291464,
-0.04231199,
-0.004853744,
0.0073927273,
-0.015247088,
0.028357472,
-0.0011647997,
-0.032789152,
0.003577658,
-0.0043360554,
-0.0027714483,
-0.0050219106,
-0.010525239,
0.005747334,
0.039067365,
-0.023239939,
0.009397535,
-0.021868227,
-0.009404129,
0.015194329,
-0.03975322,
-0.009331587,
0.019072048,
-0.021617627,
-0.0037491217,
-0.0075180274,
0.0015019568,
0.0034886287,
0.002336194,
0.010953899,
-0.015550447,
-0.015247088,
-0.010947304,
0.0028967487,
-0.017054053,
-0.015260277,
-0.033554144
] |
Pancytopenia is a major cause of morbidity in acute myeloid leukemia (AML), yet its cause is unclear. Normal osteoblastic cells have been shown to support hematopoiesis. To define the effects of leukemia on osteoblastic cells, we used an immunocompetent murine model of AML. Leukemic mice had inhibition of osteoblastic cells, with decreased serum levels of the bone formation marker osteocalcin. Osteoprogenitor cells and endosteal-lining osteopontin(+) cells were reduced, and osteocalcin mRNA in CD45(-) marrow cells was | [
-0.016509641,
-0.020933028,
0.012899376,
-0.0479287,
-0.025447484,
0.025200294,
-0.01695198,
0.009536302,
-0.02698266,
0.009718441,
0.004761646,
0.0003854201,
0.031952463,
0.014675236,
-0.037078388,
-0.0013262029,
0.04334919,
0.007051399,
-0.00574715,
-5.066135e-7,
-0.028049476,
0.013009962,
0.0013481572,
-0.013920658,
0.0076433523,
0.010134759,
0.008638614,
-0.042646654,
-0.0041696928,
-0.0078059766,
0.021011088,
0.009146003,
-0.0025873561,
-0.0027076981,
-0.0120016895,
-0.010433989,
0.0331754,
-0.015533893,
0.014597177,
-0.0014880144,
0.0029857862,
0.01722519,
-0.0019384843,
-0.008202781,
0.0038834733,
0.0021011087,
0.008248315,
0.00818977,
-0.009685916,
0.006290316,
0.0263842,
-0.004703101,
0.009250082,
0.021232257,
-0.024172507,
-0.012600147,
0.0009212679,
0.022858502,
-0.006387891,
-0.021934794,
0.008235306,
0.0089248335,
-0.01683489,
0.009789996,
-0.0032215917,
0.01334822,
-0.0011448766,
0.01338725,
-0.00068261643,
-0.01196266,
0.03437232,
0.019540962,
0.0063586184,
-0.006469203,
-0.0045014466,
-0.0011855328,
-0.014519117,
-0.0013449048,
-0.014831356,
0.0042867824,
0.020646809,
-0.017329268,
-0.024289597,
0.022155965,
0.020607779,
0.002419853,
-0.0067716846,
0.009881065,
0.0114943,
0.013764539,
0.0047551407,
0.020438649,
0.035048835,
0.019267753,
-0.015768073,
0.014454067,
0.008801239,
0.03718247,
0.017355287,
-0.028283656,
-0.022663353,
-0.0010895842,
-0.012359464,
-0.018682305,
-0.0394462,
-0.00033419338,
-0.012034214,
0.0059357947,
0.021206237,
-0.006069147,
-0.031796344,
0.030521369,
0.017771607,
-0.06369677,
0.04350531,
-0.018487155,
-0.0030866133,
0.0065570204,
-0.00859308,
0.011208082,
0.029142313,
0.026410222,
0.012248878,
-0.008391425,
0.011416241,
0.0040623606,
-0.020438649,
-0.013198606,
-0.015742052,
0.010590108,
0.011299151,
0.003948523,
0.0080466615,
0.0059162797,
-0.025291365,
0.0132766655,
-0.015520884,
-0.023509,
-0.014597177,
-0.041449737,
-0.012060234,
0.02392532,
0.013907649,
-0.012450533,
-0.004677081,
0.013764539,
0.008957358,
-0.02375619,
0.012281404,
-0.0086321095,
-0.00677819,
-0.021180216,
0.012866852,
-0.012977436,
0.0046120314,
-0.012105769,
0.014284938,
0.041996155,
-0.02373017,
-0.035335056,
-0.003415115,
-0.019462902,
0.031640224,
0.005200732,
0.006095167,
0.025421465,
0.0052625295,
0.014011729,
-0.006693625,
-0.02046467,
0.018200936,
0.02054273,
-0.017602477,
0.022598302,
-0.025265345,
0.011787025,
-0.022832481,
0.016236432,
-0.027086738,
-0.020477679,
-0.017498398,
0.0141548375,
0.009211052,
0.0062057516,
0.0022165722,
0.002839424,
0.03411212,
-0.035048835,
0.002899595,
-0.0075132526,
0.019632032,
0.024419697,
-0.001770981,
-0.0083589,
-0.63946563,
-0.037078388,
0.004280277,
0.002201936,
0.029012214,
0.015312725,
0.018942503,
-0.02726888,
-0.023977358,
-0.013855609,
-0.008001126,
0.009640382,
0.011110507,
-0.03309734,
-0.001975888,
-0.025577584,
-0.025642633,
-0.025434474,
0.012710732,
-0.005252772,
-0.009185033,
-0.014402027,
-0.016522652,
0.019280763,
-0.00208322,
0.009263093,
0.031900425,
-0.006797705,
-0.00067489175,
0.049073573,
-0.01706907,
0.022129944,
-0.014740286,
0.010876328,
0.053106662,
0.011422746,
-0.012352958,
0.019098623,
-0.004059108,
0.027633158,
0.007955591,
0.0025060438,
0.007487233,
-0.0053015593,
-0.015195635,
0.0013953183,
0.004094885,
0.011669936,
-0.012196839,
0.00336958,
0.007779957,
0.008261326,
-0.016964989,
0.01722519,
0.01995728,
0.000055089055,
0.015950212,
-0.00990058,
0.00045453553,
-0.030651469,
0.0041599353,
0.010349425,
-0.022142954,
-0.026032932,
-0.0062610437,
0.017602477,
-0.008313365,
0.009198043,
-0.008983378,
-0.01171547,
0.037911028,
0.0039290083,
-0.021986835,
0.009282608,
0.015742052,
0.019241733,
-0.005379619,
0.012593643,
-0.018318025,
-0.007831996,
0.001704305,
0.00013599475,
-0.022585293,
-0.00015622117,
0.045248646,
-0.0074937376,
-0.026514301,
0.008638614,
0.014011729,
-0.013185596,
0.0014042627,
0.0043941145,
-0.012626167,
-0.0671314,
-0.025382435,
0.01687392,
-0.00039964975,
0.004839706,
0.02357405,
-0.028804054,
-0.0329152,
0.016054291,
0.010011165,
0.014584167,
0.0031012495,
0.016522652,
-0.02646226,
-0.017355287,
0.036115654,
-0.02327482,
0.017810637,
0.00025471064,
0.014415037,
-0.023743179,
0.0073506283,
-0.0061667217,
0.0069017843,
0.007818987,
-0.021297306,
-0.013842599,
-0.000063626845,
0.01366046,
0.019163674,
-0.007923067,
-0.00165877,
-0.014219888,
0.02017845,
-0.004133915,
-0.004839706,
-0.029090274,
0.0003289081,
0.0018474145,
0.03033923,
-0.022194995,
0.05084293,
-0.0043030446,
0.023105692,
-0.01654867,
0.03645391,
-0.020568749,
-0.026058953,
-0.01021282,
0.001764476,
-0.0029678973,
-0.008196276,
0.0074937376,
-0.017511409,
-0.0075327675,
0.00842395,
0.010681178,
-0.012606652,
-0.009959125,
-0.010713703,
0.02030855,
0.02049069,
-0.008931339,
-0.0061699743,
-0.00841094,
0.0045990213,
-0.029012214,
-0.01017379,
-0.0050934,
0.005086895,
0.021596536,
0.012365968,
-0.0152867045,
-0.020399619,
0.013237636,
0.0031158857,
-0.00336958,
0.007825492,
-0.0111430315,
-0.014896406,
-0.004836453,
-0.013153071,
0.0027402232,
-0.0066448376,
0.000011256666,
-0.0152867045,
-0.006521243,
0.0120016895,
-0.015338744,
0.00066838675,
-0.00013050617,
0.009015903,
0.0141548375,
0.03387794,
0.027216839,
-0.003063846,
0.023860268,
-0.0021677848,
0.030677488,
-0.03338356,
0.012847337,
0.01999631,
-0.03775491,
-0.009321637,
0.014857376,
0.010772248,
0.041944116,
0.0059715724,
-0.013777549,
0.028491816,
0.0021661585,
0.021245267,
-0.014740286,
-0.005750403,
-0.018812403,
-0.0036720615,
0.0048136855,
-0.000042358606,
-0.0028085255,
-0.013855609,
-0.014297947,
0.014922425,
-0.009770481,
-0.0036720615,
-0.0026377696,
0.00670013,
-0.030521369,
-0.011084487,
0.008040156,
0.018174917,
-0.027815297,
0.008859783,
0.019593002,
0.024523778,
0.014167848,
0.011273132,
-0.0004358337,
-0.017381309,
0.013543369,
0.009360667,
-0.0009928227,
-0.0013790559,
0.011689451,
0.015924193,
-0.006222014,
0.033019282,
-0.00495029,
0.0071684886,
0.022038875,
-0.0031988241,
0.018213946,
-0.00031691452,
-0.015156605,
0.03333152,
0.014493097,
-0.022611313,
0.03340958,
-0.0047063534,
0.015585934,
-0.024107458,
0.004735626,
-0.015234665,
0.0036720615,
0.0050055827,
0.01999631,
0.031380028,
0.018252976,
0.031848386,
-0.018903473,
0.007415678,
0.0005435724,
-0.015677003,
0.0078580165,
0.018448126,
-0.007792967,
0.0031077545,
-0.0040883804,
-0.05058273,
-0.010355929,
0.02010039,
-0.04412979,
-0.002421479,
0.0203736,
0.009386687,
0.020841958,
0.035465155,
-0.0022116934,
-0.012775782,
-0.0336958,
0.01637954,
0.023704149,
-0.0108503075,
0.0075132526,
-0.014545137,
-0.0231187,
0.0030996234,
0.014141828,
0.022155965,
0.004410377,
0.004371347,
-0.0007358759,
-0.028752014,
-0.021453425,
0.004403872,
0.012509078,
0.034528438,
-0.0015758316,
-0.0035679818,
-0.009757471,
-0.02726888,
0.002613376,
0.017407328,
0.008586574,
0.019150663,
-0.018526185,
-0.029506592,
-0.019280763,
-0.0054121437,
-0.01347832,
-0.0029353725,
-0.012951417,
-0.014662227,
0.0028361715,
0.016405562,
0.021752656,
0.013621429,
-0.009770481,
-0.009601352,
-0.023782209,
-0.006023612,
-0.021089148,
0.018825414,
0.013582399,
0.0019287268,
0.0022051884,
-0.015403794,
0.002255602,
0.017381309,
-0.007936076,
0.020737879,
-0.0051551973,
-0.0038899784,
0.012626167,
0.008697159,
0.0061504594,
0.002772748,
0.026306141,
-0.0029207363,
-0.028830074,
0.0014465451,
-0.002169411,
-0.0052625295,
0.0015693266,
0.04376551,
0.029376492,
0.019527951,
0.013179091,
-0.0024133478,
0.005308064,
-0.0054251538,
0.012762772,
-0.014870386,
0.015690014,
-0.0020620788,
-0.0024637615,
-0.0036753141,
-0.03437232,
0.0034443873,
-0.008053166,
-0.00852803,
0.0012790419,
0.02291054,
0.008580069,
-0.0012457038,
-0.011429251,
-0.00843696,
-0.0061374493,
0.02065982,
0.010323404,
0.0057536555,
-0.024393678,
0.03437232,
-0.015104565,
-0.0118846,
-0.011422746,
0.024992136,
0.020269519,
-0.025031166,
-0.0013676722,
-0.023912309,
0.015781082,
-0.0036753141,
-0.026410222,
0.00833288,
0.003733859,
-0.015846133,
-0.017589469,
-0.022116935,
0.003164673,
-0.03275908,
0.0107657425,
0.016262451,
-0.010759238,
-0.041033417,
-0.0054414165,
0.0062122564,
0.026215073,
0.029324453,
-0.018565215,
-0.018591234,
0.016886929,
-0.016132353,
0.0016734062,
-0.012359464,
-0.036427893,
0.0046282937,
-0.009080953,
0.0017108099,
-0.007825492,
-0.009627371,
-0.0012676581,
-0.006452941,
-0.0066383327,
-0.017641507,
0.00046551268,
-0.0076433523,
0.0045079514,
0.004602274,
0.021440417,
-0.017680537,
-0.0074612126,
-0.013608419,
-0.026267111,
-0.035387095,
0.004280277,
-0.037234508,
-0.014948445,
-0.022103924,
0.022715392,
-0.019462902,
-0.010707198,
0.013315695,
-0.011077982,
0.008658129,
-0.0075848075,
0.0061472068,
0.0028085255,
0.028101517,
0.024432708,
0.03314938,
-0.0060821567,
0.013725509,
-0.001984019,
0.024744947,
0.014935436,
-0.010655158,
-0.011689451,
0.003263874,
-0.024705917,
-0.028179577,
-0.022767432,
-0.005834968,
0.025603604,
-0.012899376,
-0.007734422,
-0.022650342,
-0.00068749517,
0.0059065223,
0.0123984935,
0.009659897,
-0.01669178,
-0.003880221,
0.020841958,
0.003489922,
-0.025408454,
0.025070196,
-0.037963066,
-0.0056658383,
0.017537428,
-0.0022913795,
-0.030521369,
-0.036271773,
0.02373017,
-0.016509641,
-0.0029597662,
-0.021102156,
-0.024029398,
0.011201576,
-0.01338725,
0.03309734,
0.035335056,
0.04423387,
0.007727917,
0.025850793,
0.0029109789,
-0.011572361,
0.009575332,
-0.012261889,
0.022806462,
0.0027304657,
0.025564574,
-0.00071758067,
0.0044689216,
0.028413756,
-0.029090274,
0.027997436,
0.019410862,
-0.009224063,
-0.01163741,
0.008105206,
-0.018265985,
-0.033851918,
0.026215073,
-0.028179577,
0.002792263,
-0.018851433,
-0.007936076,
0.045638945,
0.00043624025,
-0.006960329,
-0.012561117,
0.021765666,
-0.0063163363,
0.01695198,
-0.012736752,
0.0017921221,
-0.018005786,
-0.006394396,
0.008502009,
-0.009412707,
0.0020653314,
-0.008651624,
0.018955514,
0.010973902,
-0.031926446,
-0.004709606,
0.008456475,
-0.018213946,
-0.017368298,
-0.019501932,
-0.020854969,
-0.03010505,
0.009913591,
-0.004696596,
-0.035621274,
-0.004670576,
0.013608419,
-0.028543854,
0.007012369,
0.0058447253,
-0.008124721,
0.04064312,
-0.019501932,
0.013816579,
-0.035725355,
0.0064464356,
0.0013904396,
-0.0105575835,
-0.019137653,
-0.00071839377,
-0.00032687528,
0.015729044,
0.02017845,
0.014623197,
-0.02992291,
0.00034395084,
-0.003971291,
0.0028247877,
0.0049372804,
-0.008241811,
0.020959048,
-0.0064301733,
0.0037761412,
-0.0059715724,
-0.022012854,
-0.014232897,
-0.014167848,
-0.0038932308,
0.002247471,
0.016405562,
-0.010089225,
-0.0068757646,
0.035100877,
-0.0075913123,
-0.0027125769,
0.0010952761,
-0.010785257,
0.0038314336,
-0.012470048,
-0.035204954,
0.03728655,
-0.015000485,
0.03705237,
-0.0065147383,
0.0044006193,
0.0047128582,
-0.00027991744,
0.008085691,
0.0045762537,
-0.02030855,
0.036011573,
0.0018327783,
0.021934794,
0.016145362,
0.009067943,
0.00038196432,
-0.018851433,
-0.012944912,
0.0014888274,
-0.045092527,
0.013764539,
0.03033923,
0.009796501,
-0.006322841,
0.0135693895,
-0.038457446,
-0.025577584,
-0.009750966,
-0.03720849,
-0.0042022173,
-0.03039127,
-0.012047224,
0.005327579,
0.022572283,
-0.0054446687,
-0.004927523,
-0.005545496,
0.0048787356,
0.0038509485,
0.0020214228,
0.01687392,
0.0058447253,
0.0022198246,
-0.026358182,
-0.0064106584,
-0.018708324,
-0.029662712,
-0.011149537,
-0.014389018,
-0.024159499,
-0.027216839,
-0.01701703,
0.011227597,
-0.001233507,
-0.007038389,
0.017914716,
0.00491126,
0.035074856,
0.0030492097,
-0.017498398,
0.021947805,
-0.021453425,
0.006940814,
0.014389018,
0.007968601,
-0.010895843,
0.011221091,
0.014258917,
0.0013392129,
0.0068952795,
-0.00033642945,
-0.00039050213,
0.0036492941,
0.004784413,
-0.0005431659,
-0.02352201,
0.00027890105,
-0.007448203,
0.015768073,
0.00096842897,
0.008658129,
-0.009718441,
-0.009347657,
-0.011188567,
0.015429814,
-0.012671703,
0.008638614,
0.013894639,
-0.011656925,
-0.034710575,
0.011025942,
-0.01159838,
0.029558633,
-0.003236228,
0.013022971,
-0.029948931,
0.0008871167,
-0.048423074,
-0.01718616,
0.011357696,
0.0041761976,
0.0171081,
0.01993126,
-0.0054967087,
0.013003456,
-0.006111429,
0.014753296,
-0.010024175,
0.00010804366,
0.0010847055,
-0.005961815,
0.012515583,
-0.0039225034,
-0.01366046,
-0.018344045,
0.014076778,
-0.02015243,
-0.008495505,
0.04428591,
-0.0010562462,
0.0076563624,
-0.008430455,
0.010258354,
0.0027890105,
0.019033574,
0.0070774187,
-0.017095089,
-0.015156605,
0.020594768,
-0.0008009257,
0.0021043613,
0.0003642789,
-0.0057406453,
-0.009913591,
-0.0068757646,
-0.019449892,
-0.019619022,
0.0093021225,
-0.008872794,
0.021830715,
0.01693897,
0.0023320355,
0.015091555,
-0.0008456475,
0.0068952795,
-0.000064084226,
-0.0016864162,
-0.002434489,
-0.00047689638,
0.0055552535,
0.014180858,
-0.02706072,
0.021089148,
0.00004342583,
-0.025642633,
0.001200169,
0.002818283,
-0.00097493397,
-0.032186646,
0.020750888,
-0.011481291,
0.007910056,
0.0005956123,
-0.022702383,
-0.019020563,
-0.03018311,
0.004423387,
-0.007740927,
-0.018838424,
-0.01701703,
0.0100567,
0.003541962,
0.008567059,
0.012079749,
-0.011175557,
-0.015755063,
0.014519117,
0.17110701,
-0.026553331,
-0.003242733,
-0.0091329925,
-0.00076148927,
-0.01342628,
0.009568826,
-0.0052820444,
-0.012951417,
0.021375366,
0.037650827,
-0.0017189411,
0.012886367,
-0.0013945053,
0.010336414,
-0.017745588,
-0.014831356,
0.011221091,
-0.020893998,
-0.010089225,
-0.0033338026,
0.007357133,
0.02674848,
0.004855968,
0.031432066,
0.024159499,
-0.018292006,
0.03325346,
0.03629779,
-0.0078059766,
-0.010726713,
0.01366046,
-0.022832481,
-0.007734422,
0.01008272,
-0.01192363,
-0.019124644,
-0.017407328,
-0.0023385405,
0.0034671547,
-0.0043420745,
0.007851511,
-0.009412707,
0.017394317,
-0.00080580445,
0.03322744,
-0.005256024,
-0.0037631313,
-0.015755063,
-0.0018327783,
-0.037702866,
0.004722616,
0.015377774,
0.008755704,
0.017628498,
0.012938406,
0.01991825,
0.008957358,
-0.008137731,
0.017407328,
0.013803569,
-0.000051277544,
-0.008248315,
0.022689372,
-0.017576458,
0.018331036,
-0.0046120314,
-0.018682305,
-0.0014945193,
-0.008280841,
-0.008176761,
-0.0119171245,
0.009516787,
-0.005685353,
0.0049015027,
-0.014271927,
0.0054836986,
0.03338356,
0.005581273,
-0.015117575,
-0.0037826463,
0.009399697,
-0.022624323,
0.015937202,
-0.008671139,
-0.027763257,
0.0034053572,
0.027945397,
-0.003171178,
-0.012092759,
0.0017807385,
-0.023912309,
-0.0024686402,
0.008599584,
0.016080312,
-0.0065830406,
0.007779957,
0.008957358,
-0.012775782,
-0.01012175,
-0.041657895,
0.08222295,
-0.002727213,
-0.0020913512,
-0.0070774187,
0.0075913123,
-0.026006913,
0.02352201,
-0.02732092,
0.017810637,
0.009341152,
-0.028725995,
-0.0032329753,
-0.007871026,
-0.004325812,
-0.00090256607,
0.00677819,
-0.023951339,
0.04040894,
-0.02695664,
-0.02719082,
-0.019827181,
0.009165518,
0.0270347,
0.0094257165,
0.011774015,
-0.022793451,
-0.0051779645,
-0.02379522,
-0.0009293991,
-0.01981417,
0.008944348,
0.005366609,
0.014948445,
-0.005711373,
0.020438649,
0.012515583,
-0.0010074589,
-0.01662673,
0.00420547,
-0.017043049,
-0.015416804,
0.025395444,
0.0069278046,
0.00093509094,
-0.021323327,
0.01654867,
0.010830793,
-0.03668809,
-0.022481212,
-0.02388629,
-0.037572768,
-0.012170819,
0.00986155,
0.022208003,
-0.01334822,
-0.009575332,
-0.029480573,
0.009620867,
0.02373017,
-0.0105575835,
0.025746712,
0.006547263,
-0.016015261,
0.0122944135,
-0.011364201,
-0.16173984,
-0.009646886,
0.012775782,
-0.007467718,
0.028908134,
0.016483622,
-0.008859783,
-0.026358182,
-0.025122235,
0.0016343764,
0.035595253,
-0.00019291333,
-0.031041767,
0.005213742,
0.010804772,
-0.024940096,
0.0045730015,
0.02384726,
0.033357542,
0.025226315,
0.022286063,
-0.0071489736,
0.025447484,
0.0024523777,
-0.0072790734,
0.014831356,
0.028127536,
0.0016189271,
-0.004602274,
-0.00826783,
-0.021856735,
-0.0084434645,
0.003955028,
-0.0092175575,
-0.008807744,
-0.0048299483,
-0.0030329472,
-0.012418008,
0.025928853,
0.0042867824,
0.029220372,
0.0041436725,
0.00011139779,
0.008703664,
-0.0026101235,
0.042412475,
0.01673081,
-0.010616128,
0.0397064,
-0.016964989,
0.041631877,
-0.019397853,
0.0038281812,
0.019775141,
-0.018474145,
0.029324453,
0.008918328,
0.002029554,
0.0125025725,
0.001531923,
-0.008710169,
-0.013842599,
0.007968601,
0.008456475,
0.0046673235,
-0.025746712,
-0.000686682,
0.02997495,
-0.0270347,
0.0009822521,
-0.031458087,
-0.014636206,
0.013868619,
-0.000915576,
0.02706072,
0.023977358,
-0.014011729,
0.017589469,
0.008898813,
0.032576945,
-0.010375444,
0.022429174,
-0.028361715,
-0.016236432,
-0.03629779,
0.00057487766,
0.019332802,
0.034346297,
-0.021323327,
-0.033045303,
0.021232257,
-0.03348764,
-0.011390221,
-0.0102843745,
0.017641507,
0.039576303,
-0.026215073,
-0.01003068,
0.017368298,
0.0031191383,
0.040721178,
-0.026163032,
-0.014128818,
-0.0063846386,
0.045248646,
-0.017719567,
-0.008671139,
-0.009237072,
0.029246394,
-0.0032492378,
-0.0071619838,
0.01722519,
-0.0007688074,
0.009282608,
0.00028804867,
0.0014018234,
0.021895764,
-0.00090581854,
-0.008989884,
-0.009360667,
0.07228334,
0.0030280685,
-0.025239324,
0.0398365,
-0.015273695,
-0.01153333,
-0.12885065,
-0.017095089,
-0.009230567,
0.019215712,
-0.018135887,
0.014011729,
-0.01683489,
0.018552205,
0.0026231334,
0.026410222,
-0.031822365,
-0.017199168,
-0.013081516,
-0.012144798,
0.030599428,
0.00681722,
0.0060593896,
-0.014870386,
-0.031614207,
0.02659236,
-0.00040798425,
0.0053828713,
0.008983378,
-0.004683586,
0.016171383,
0.007285578,
-0.02332686,
0.029714752,
0.011357696,
0.019749122,
0.03689625,
0.0002575566,
0.01964504,
-0.0072725685,
-0.011357696,
-0.0028329191,
-0.01000466,
-0.016431581,
0.028517835,
-0.025512533,
-0.0014497975,
0.038301326,
0.00500233,
-0.022871511,
0.015130585,
-0.017277228,
-0.027997436,
0.017498398,
0.031822365,
-0.013146566,
-0.015624964,
-0.04085128,
-0.025174275,
-0.007318103,
0.038457446,
-0.000042180734,
0.0017612235,
0.028621914,
-0.02739898,
-0.0005480446,
0.0153907845,
-0.015130585,
-0.004172945,
0.0047453833,
0.027789278,
-0.019736111,
0.0026898095,
-0.031249927,
0.024029398,
-0.027138779,
0.001975888,
-0.00020775282,
-0.017199168,
-0.02319676,
-0.007773452,
-0.0134523,
-0.022598302,
-0.011377211,
0.0015433066,
-0.015846133,
-0.025122235,
-0.014519117,
0.011338181,
-0.009913591,
0.03778093,
0.00668712,
0.019579992,
0.0072725685,
0.0024328628,
-0.0074742227,
-0.008619099,
0.037989087,
-0.0033338026,
-0.0101802945,
-0.015234665,
0.0016229927,
0.017940737,
-0.026058953,
0.022351114,
0.021648575,
-0.0133612305,
-0.032108583,
-0.03671411,
0.021531485,
0.0076238373,
-0.007357133,
0.0060821567,
-0.015039516,
0.011012932,
-0.027477039,
0.00859308,
0.018526185,
-0.016431581,
0.004703101,
-0.014740286,
0.0010220951,
-0.008905319,
-0.014193867,
0.032707043,
-0.004436397,
0.015273695,
0.01687392,
0.0025385688,
0.00033012778,
0.0119171245,
0.023131711,
0.006504981,
-0.011448766,
-0.017238198,
0.02352201,
-0.008651624,
-0.010076215,
0.0011489422,
-0.057660148,
-0.009588341,
-0.024328627,
-0.015729044,
-0.031484105,
-0.007740927,
0.02017845,
0.01989223,
0.02992291,
0.009152507,
-0.0201134,
0.027138779,
-0.007357133,
-0.0034931747,
0.018435115,
-0.017628498,
0.008710169,
-0.004358337,
-0.012957921,
0.038561527,
-0.003948523,
0.00838492,
-0.04438999,
-0.0066383327,
-0.0021124925,
-0.0017791121,
-0.009855046,
-0.0063130837,
0.015156605,
0.008742694,
0.015208645,
-0.017394317,
-0.021310316,
-0.017381309,
-0.013816579,
-0.0062642964,
0.004150178,
-0.0015343623,
-0.021557506,
-0.021531485,
0.008131226,
-0.005711373,
-0.0068042097,
0.022481212,
0.011364201,
0.0035126896,
0.005256024,
-0.009048428,
0.015325734,
0.0118846,
-0.0035517195,
0.00420547,
0.009874561,
0.027945397,
-0.0043680943,
-0.022064894,
0.044520088,
-0.0014156464,
-0.008599584,
-0.025291365,
0.015065535,
0.008469485,
0.02663139,
0.029064253,
0.021115167,
-0.0048722303,
0.0030768558,
0.017199168,
0.035491176,
-0.0072790734,
-0.0065342532,
-0.004260762,
-0.02343094,
-0.023183752,
0.022129944,
-0.0538092,
-0.039810482,
-0.008209285,
0.0076238373,
0.017862678,
0.021297306,
0.0054967087,
0.00844997,
-0.013972699,
0.022286063,
-0.007363638,
0.01170246,
-0.00068139675,
0.045508843,
0.021063127,
0.005532486,
-0.009490767,
-0.0007000985,
0.02042564,
-0.009640382,
0.008853279,
-0.03054739,
0.022390144,
-0.0028068991,
0.030729529,
-0.00054641836,
-0.041683916,
-0.004716111,
0.009100468,
-0.021232257,
0.032368783,
0.027086738,
-0.007955591,
0.06057438,
-0.010629138,
-0.012801802,
-0.00011332896,
-0.010635643,
0.007753937,
0.0006415537,
0.008502009,
-0.005125925,
-0.02706072,
0.017082078,
-0.028465794,
0.02021748,
-0.034476396,
-0.027685197,
0.016301481,
0.018122876,
-0.00672615,
-0.006631828,
-0.004761646,
-0.0047714035,
-0.003218339,
-0.001512408,
0.030885648,
-0.031536147,
0.009250082,
0.014675236,
-0.017134119,
0.003078482,
-0.03752073,
0.00498932,
-0.009516787,
-0.044520088,
-0.012021204,
0.0038054136,
-0.0084434645,
-0.010512048,
-0.038483467,
0.0040883804,
0.01995728,
-0.034528438,
0.022689372,
-0.027659178,
-0.022702383,
-0.01171547,
-0.023079671,
-0.010453504,
-0.018773373,
-0.0064269206
] |
Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy | [
-0.034498893,
-0.008480322,
-0.0066063805,
-0.026346756,
-0.04011743,
-0.015398478,
-0.017315084,
0.028328998,
-0.01411199,
0.0049326327,
0.007325107,
-0.021647137,
0.014335156,
0.008572213,
-0.023918182,
-0.012904266,
0.03583789,
-0.015149057,
-0.03583789,
0.015057165,
-0.030849466,
0.036468007,
-0.01738072,
0.0008508217,
-0.0329236,
0.028749077,
0.011204263,
-0.04135141,
0.013114305,
-0.016960643,
0.0049359147,
-0.0077976948,
-0.003537843,
0.018181494,
0.014820871,
-0.010725113,
0.0053920927,
-0.018995395,
0.019546747,
0.00434518,
0.019861804,
-0.0067606275,
-0.0047718217,
-0.00014768362,
0.013823186,
-0.0088478895,
0.0081980815,
-0.0027140966,
-0.00092712493,
0.017105045,
0.03266105,
0.004230315,
-0.020872617,
0.019914314,
-0.002308787,
-0.018890375,
-0.0157923,
0.036468007,
0.0030734602,
-0.012943648,
-0.027278805,
0.003977612,
-0.011210827,
0.0217259,
-0.0045224004,
0.0130355405,
0.0307707,
0.032949854,
-0.0023268373,
0.0101212505,
0.025703512,
0.027068766,
0.0036231712,
-0.013389981,
-0.0044928635,
-0.00443379,
-0.024023201,
0.008559085,
-0.021148294,
0.008394993,
0.0062224027,
-0.018982267,
-0.003491897,
0.035969164,
0.005313328,
-0.0068722107,
0.005208309,
-0.00076221157,
0.016527437,
-0.011453684,
0.010613529,
0.026373012,
0.007974915,
0.028696567,
0.0012216717,
0.016684966,
0.003839774,
0.013009286,
0.023970691,
-0.025414709,
0.009753683,
0.038673416,
0.0063307043,
-0.017918944,
-0.032949854,
-0.003977612,
0.0037544456,
-0.0063897776,
0.029169155,
-0.012838629,
-0.020334393,
0.020964509,
-0.004453481,
-0.043084234,
0.022973007,
0.00605831,
0.012904266,
0.013757549,
0.011893454,
-0.0067475,
0.011178008,
0.030796956,
0.032949854,
0.0038660287,
0.01605485,
-0.006721245,
-0.0012996158,
0.0063503953,
-0.03652052,
-0.00365599,
0.0061436384,
0.021542117,
0.026071081,
0.010902332,
-0.020176863,
-0.020137481,
-0.020176863,
-0.022356017,
-0.034708932,
-0.010922024,
0.0030488463,
0.02725255,
-0.043084234,
0.0044469177,
-0.017748289,
0.018850993,
0.031768385,
0.0029503903,
0.024548298,
0.000057124842,
0.003511588,
-0.0223954,
0.007961787,
-0.0063536773,
-0.014033225,
0.004348462,
-0.0018837865,
0.042664155,
-0.01953362,
-0.012891139,
0.038017046,
0.002079057,
0.01764327,
0.019638639,
0.026149845,
0.011138626,
-0.00078231294,
0.00087543565,
-0.0029963364,
-0.0061895843,
0.011716234,
0.029983055,
-0.025020886,
0.024010073,
-0.021450225,
-0.00874287,
-0.023760652,
0.02361625,
-0.029484212,
-0.025519729,
-0.0075285826,
0.01717068,
0.027016256,
-0.012228203,
0.00072159857,
0.0041745235,
0.04429196,
-0.017984582,
-0.0075023277,
-0.018798484,
-0.008388429,
0.020701962,
-0.0058154524,
-0.025900424,
-0.62759626,
-0.008854453,
0.03644175,
-0.007535146,
0.008874144,
0.020084972,
-0.0051918994,
-0.031663366,
-0.018837865,
0.013941333,
-0.0056743324,
0.036573026,
-0.0040399674,
-0.014400793,
-0.006238812,
-0.031820897,
-0.018496552,
-0.026320502,
0.0029667998,
0.007843641,
-0.000543968,
0.007725494,
-0.013836314,
0.017210064,
-0.0029438266,
0.036362987,
0.022867987,
-0.0035739434,
0.018220875,
0.03528654,
-0.029536722,
0.034131326,
-0.0031751976,
0.0020314702,
0.049674205,
0.026661815,
-0.0030947921,
0.025112778,
0.029694252,
0.008716615,
0.0053100465,
0.0002799835,
0.031532094,
-0.011873762,
-0.030481897,
0.028381508,
-0.019231688,
0.009294222,
-0.012156002,
-0.003216221,
0.009281094,
0.002010138,
-0.026504286,
-0.014728979,
0.043031722,
0.0020642888,
0.022001576,
-0.0069247205,
0.00540522,
0.007725494,
0.020596942,
0.023839418,
-0.017288828,
-0.016199252,
0.004814486,
0.024810847,
0.0025303126,
0.022421654,
0.0033245222,
0.019822422,
0.012129747,
0.039749864,
-0.01784018,
-0.013849441,
0.012602335,
0.020255627,
0.0036100438,
0.0088478895,
0.008854453,
0.0050376523,
0.031112015,
-0.0015777532,
-0.020715088,
0.026162973,
0.0023022234,
0.015017782,
-0.018430915,
0.02177841,
-0.010278779,
0.006242094,
0.007285725,
0.004883405,
-0.017065663,
-0.057603173,
-0.01815524,
0.03006182,
-0.0012733609,
0.011256773,
0.0014505812,
-0.016199252,
-0.006455415,
0.004830895,
0.019310452,
0.0065177702,
0.014046352,
0.002700969,
-0.014098862,
0.008335919,
0.04095759,
-0.04565721,
0.031059505,
0.001584317,
0.0049293507,
-0.01738072,
0.00789615,
-0.020938255,
-0.0052772276,
0.016842496,
-0.0006145279,
-0.009084183,
0.016094232,
-0.0011962373,
0.01732821,
-0.0032752943,
0.030088075,
0.0063963416,
-0.0088478895,
-0.033632483,
-0.03184715,
-0.009720864,
-0.00002539594,
-0.0034557965,
0.016579947,
-0.01850968,
0.006780319,
0.0047685397,
0.0009115361,
0.011729361,
0.0098127555,
-0.038463376,
-0.035444066,
-0.014912763,
0.023550613,
-0.010042486,
-0.018798484,
0.011801561,
-0.033054873,
0.005483985,
0.00040756576,
0.0179452,
-0.019756787,
0.0046044467,
-0.012392296,
0.012339787,
0.026451776,
-0.008913526,
0.0040891953,
-0.024732083,
-0.000948457,
-0.013048667,
-0.022644822,
0.0017525122,
0.005162363,
-0.0041252957,
0.0032441167,
-0.0005583261,
-0.027856411,
-0.00012132619,
-0.020006206,
-0.034498893,
-0.01160465,
-0.016619328,
-0.027830156,
0.02898537,
0.0071085044,
0.002636973,
-0.007935532,
-0.009694609,
-0.007055995,
-0.0155953895,
-0.01107299,
-0.022080341,
0.009071056,
0.0042171874,
0.029825525,
0.020885745,
0.016908133,
0.0049063778,
-0.011788434,
0.025624748,
-0.015687281,
0.009576462,
-0.016724348,
0.017078789,
0.011250209,
-0.03174213,
-0.0027206603,
0.003468924,
-0.0053067645,
0.010009667,
-0.0066949907,
-0.019861804,
0.034367617,
-0.003495179,
-0.0016286221,
-0.013915078,
0.0060615917,
-0.009248276,
0.023471849,
-0.019297326,
-0.0136919115,
0.012517007,
-0.014177627,
-0.00007379053,
-0.0039251023,
0.012740173,
-0.0107776215,
-0.01247106,
-0.0028831123,
-0.0042434423,
-0.011269901,
0.0058778077,
0.021804664,
-0.012287277,
-0.008880708,
0.013376853,
-0.009747119,
0.009366423,
-0.0003739267,
-0.009786501,
0.011893454,
0.012110056,
0.009162948,
0.011059862,
-0.000017152837,
-0.0060648737,
0.00085902633,
-0.023340575,
0.057025567,
-0.0012528494,
0.022867987,
0.026097335,
-0.00016983616,
0.011532449,
-0.019796168,
-0.008775689,
0.01554288,
0.0078895865,
-0.0058121704,
-0.00035813276,
-0.013560638,
0.020373775,
-0.011243646,
-0.008427812,
-0.010167196,
0.0070363036,
0.014479558,
0.014151372,
0.032582287,
0.010245961,
0.012313532,
0.0014317106,
-0.0014719133,
-0.0024334977,
-0.007679548,
-0.004555219,
0.019573001,
-0.02214598,
-0.028539037,
0.0013004362,
-0.012352914,
-0.0006124768,
0.027357569,
-0.031059505,
0.016908133,
0.019231688,
0.029694252,
0.010094996,
-0.006937848,
0.00240232,
0.0075548375,
-0.039040983,
0.020675706,
0.009510824,
0.0039907396,
0.001181469,
0.004043249,
0.014440175,
-0.006642481,
-0.0088413255,
0.014847126,
0.0052345637,
-0.019205434,
-0.0026107181,
0.00030582814,
0.0009041519,
-0.010213142,
-0.017157555,
0.030744446,
-0.026346756,
-0.006937848,
-0.027987685,
0.006589971,
-0.01503091,
0.0031998116,
0.016724348,
0.0014637087,
-0.0045519373,
-0.022054086,
-0.03583789,
-0.004318925,
-0.008657542,
0.013718166,
-0.025086524,
0.0054150657,
-0.012175693,
0.017577631,
-0.007292289,
0.040983845,
-0.005014679,
0.0031144833,
-0.034787696,
0.0052345637,
-0.01896914,
0.033448696,
0.017105045,
0.0075023277,
-0.007055995,
0.0101212505,
-0.007128196,
-0.005851553,
-0.017183809,
0.010429745,
-0.033973794,
-0.0003382365,
-0.019310452,
0.017446358,
0.0054971124,
-0.003024232,
0.02280235,
-0.021594627,
0.004647111,
-0.012878011,
-0.0033835957,
0.014125117,
0.005694024,
0.04830895,
0.034787696,
0.03851589,
0.021634009,
-0.028749077,
0.0315846,
-0.011893454,
-0.022250997,
-0.012175693,
0.02223787,
-0.00920233,
0.007672984,
0.012050983,
-0.018614698,
0.006566998,
-0.024325132,
-0.006826265,
0.01799771,
0.010298471,
0.020623196,
0.024876485,
-0.0009492774,
-0.012110056,
-0.016251761,
0.006891902,
0.0030865874,
0.0013094614,
-0.0062519396,
0.01906103,
-0.014282647,
0.0018854275,
-0.03707187,
0.03234599,
-0.027646372,
0.0019920878,
-0.013061795,
0.01921856,
-0.009366423,
-0.014269519,
0.004161396,
0.010554455,
-0.011788434,
0.011814689,
-0.028565293,
-0.011919709,
-0.018181494,
-0.004919505,
0.004755412,
-0.0017065662,
-0.041640215,
-0.021607753,
0.013429363,
0.016579947,
0.013770676,
0.020990765,
-0.0042598518,
-0.024613936,
0.013875696,
0.0078764595,
-0.03189966,
-0.023064898,
-0.045814738,
0.00039854064,
-0.003445951,
0.0029897727,
-0.024325132,
0.004322207,
0.005372402,
0.0035903528,
-0.014545195,
0.0139938425,
0.0034328236,
-0.010574147,
0.009911211,
0.029983055,
-0.019717403,
0.015608517,
-0.03098074,
-0.006343832,
-0.016619328,
-0.015818557,
-0.014505813,
-0.0041187317,
0.010423182,
-0.0077845673,
-0.00044715317,
-0.031453326,
-0.008184954,
0.022618566,
-0.002635332,
0.0057695066,
0.0056546414,
0.0018673772,
0.013225888,
-0.0077648764,
0.011840944,
0.00720696,
0.004965451,
0.015910449,
-0.0058679623,
0.02888035,
-0.013160251,
-0.02597919,
-0.001780408,
-0.008224336,
-0.015831683,
-0.017905818,
-0.008979164,
-0.04200778,
0.03108576,
-0.004184369,
-0.02361625,
-0.029615488,
-0.016067978,
-0.0056021316,
0.017603887,
-0.0031801204,
-0.0010846541,
-0.032582287,
0.0022267406,
0.008020861,
-0.009176075,
0.013665657,
-0.040511254,
-0.0052805096,
0.02209347,
0.015516625,
0.026517414,
-0.021804664,
0.0127204815,
-0.012438242,
0.00902511,
-0.006074719,
-0.028486528,
-0.010902332,
-0.019467982,
0.0642194,
0.031374563,
0.017249446,
0.016278015,
0.02633363,
0.008644414,
-0.0018640953,
-0.0020002925,
0.0023727834,
0.014899636,
-0.033212405,
0.017971454,
0.021030147,
0.029169155,
0.038384613,
-0.031715877,
0.006859083,
0.023655633,
-0.027803902,
-0.019192306,
0.0056743324,
0.0038988474,
-0.05035683,
0.0094780065,
-0.013179942,
0.0017689215,
-0.030298114,
0.002986491,
0.0114143025,
0.029641742,
0.009340168,
0.004919505,
0.012293841,
0.010016231,
0.011926272,
-0.011191136,
0.0010534765,
-0.007928969,
-0.01994057,
-0.006373368,
-0.01285832,
0.020386903,
0.003403287,
0.015332841,
-0.0009435342,
-0.015713537,
-0.0060254913,
-0.010711985,
-0.0037577276,
-0.007810822,
0.001352946,
-0.019126669,
-0.028381508,
-0.0030865874,
-0.032477267,
-0.019047905,
0.010416618,
0.015424733,
-0.033711247,
0.01400697,
0.003400005,
-0.015057165,
0.027016256,
-0.0004360769,
0.013179942,
-0.031427074,
0.0065801255,
0.010830131,
-0.00754171,
0.010272216,
-0.010416618,
-0.0156479,
-0.0026041544,
0.040931333,
0.004092477,
-0.014939018,
-0.02464019,
0.008132445,
0.016895005,
0.005671051,
-0.019914314,
0.016737476,
0.0063471133,
0.009261403,
-0.0143220285,
0.001155214,
-0.03444638,
0.010272216,
-0.022776095,
0.011230518,
0.014440175,
-0.015713537,
-0.030691937,
0.030298114,
0.00702974,
0.023406211,
0.004489582,
-0.012175693,
0.0073382347,
-0.004210624,
0.010035922,
0.0062585035,
0.0068525197,
0.03092823,
0.010114687,
0.0048965323,
0.019205434,
-0.019914314,
-0.011926272,
0.002661587,
-0.009071056,
0.03528654,
0.003790546,
0.0065112063,
0.0034557965,
0.037754495,
0.016133614,
-0.040379982,
-0.011847507,
0.0031784796,
-0.026911236,
-0.008644414,
0.033238657,
0.012687664,
-0.023511231,
0.010593838,
-0.014689596,
-0.0085197035,
-0.013311217,
-0.015884193,
-0.0025582083,
-0.013901951,
-0.014453303,
0.0104625635,
0.030455643,
0.022054086,
0.0029208537,
-0.020255627,
-0.0016474928,
0.026871854,
-0.024101965,
0.029746762,
-0.008998855,
0.019914314,
-0.008434375,
0.002377706,
-0.010265652,
-0.009688045,
-0.013888824,
-0.01462396,
-0.043530565,
-0.009215457,
-0.0030586917,
0.03476144,
-0.0031046378,
-0.01538535,
0.015450988,
0.020715088,
0.016435545,
-0.005726842,
-0.02561162,
-0.0104625635,
-0.000025754895,
-0.014807744,
0.022986135,
-0.02909039,
-0.016658712,
0.010127814,
-0.02110891,
0.023445593,
0.0023416057,
-0.013901951,
-0.016763732,
-0.004699621,
-0.029379193,
-0.012536698,
0.008782253,
-0.015739791,
0.0016852341,
0.008224336,
0.022566056,
-0.01784018,
-0.0050737527,
-0.0050278064,
-0.008828199,
0.013383417,
-0.03082321,
0.0042631337,
-0.0045420914,
-0.048939068,
-0.014427048,
-0.006806574,
-0.036362987,
0.024837103,
0.005372402,
0.0034262598,
-0.023458721,
-0.010239397,
-0.038778435,
-0.041167628,
0.008309664,
0.010029358,
-0.017669523,
-0.0008344124,
-0.0048013586,
0.027016256,
-0.020925127,
-0.0026779962,
0.0033901595,
-0.011013916,
0.0012241331,
-0.023091154,
0.013810059,
-0.00038807973,
-0.036835574,
-0.02822398,
0.03875218,
-0.016448673,
-0.0044501997,
-0.0042664157,
-0.02116142,
0.018588444,
-0.0026550232,
0.029326683,
0.0060451827,
0.025007758,
0.025480347,
-0.011519322,
0.011204263,
0.00046889548,
0.006662172,
-0.0021775127,
0.008040552,
-0.011283028,
0.0006026312,
0.0038003917,
0.013836314,
-0.01692126,
-0.00070149713,
-0.025388453,
0.023340575,
0.010600402,
-0.024141349,
0.017958328,
0.021660263,
-0.01881161,
-0.016750604,
-0.00429267,
-0.0034557965,
0.0011486503,
0.017708907,
-0.004272979,
-0.0039021294,
0.023708142,
0.0036691173,
-0.017131299,
-0.010515073,
-0.006721245,
-0.015962958,
-0.020373775,
0.005047498,
0.00725947,
-0.020334393,
-0.014217009,
0.001098602,
-0.013744421,
-0.011650596,
-0.007397308,
0.00044592246,
-0.0033639045,
0.014177627,
0.01937609,
-0.013298089,
0.029064136,
-0.0034196961,
-0.0037872642,
-0.013153687,
0.022854859,
0.18598945,
-0.026254864,
-0.01400697,
-0.008132445,
-0.008624723,
-0.006048464,
0.0067868824,
-0.015240949,
-0.022027832,
0.010213142,
0.01967802,
-0.0034492328,
0.009327041,
-0.0002557798,
0.008447503,
-0.009162948,
-0.013383417,
-0.0043090796,
-0.029457958,
-0.004532246,
0.012070674,
-0.020596942,
0.023222428,
0.017630141,
0.032240972,
-0.0005320712,
-0.030744446,
-0.006944412,
0.028512783,
0.006238812,
-0.008985727,
0.010521637,
-0.0040366855,
-0.005562749,
0.00062396325,
0.026622433,
-0.005621823,
-0.0058220164,
0.004528964,
-0.03092823,
-0.0008787175,
0.016606202,
0.0002252175,
0.019467982,
-0.0033261632,
0.016422417,
-0.014033225,
-0.006964103,
0.004834177,
0.0114339935,
-0.051564556,
-0.0041252957,
0.005887653,
0.018430915,
0.0012372605,
-0.0052378457,
0.03313364,
0.018890375,
-0.008139008,
0.020321265,
-0.03200468,
0.0027091738,
-0.020990765,
0.0101212505,
-0.040038668,
0.00046397268,
-0.0042270334,
0.018627826,
0.015096547,
-0.0052608186,
0.0003714653,
0.009281094,
-0.021227058,
0.017000025,
-0.0033835957,
-0.019651767,
0.025966061,
0.010790749,
0.0012758223,
0.021752154,
0.004886687,
0.0072266515,
-0.024456406,
0.010987661,
0.009215457,
-0.04166647,
0.020491922,
0.0051689264,
-0.015122802,
-0.023524359,
0.015057165,
-0.015556008,
-0.012989595,
0.002377706,
0.018115856,
-0.0019740376,
-0.012917394,
-0.0026976874,
-0.016172996,
0.0047357213,
-0.04040624,
0.080970004,
0.012825501,
0.0009911212,
-0.010561019,
-0.004394408,
0.00851314,
-0.00091235654,
-0.0028962397,
-0.0073185437,
-0.0032490394,
-0.02520467,
0.009852138,
-0.022500418,
-0.009760246,
0.01257608,
-0.0028256797,
-0.03612669,
0.039959904,
-0.01994057,
-0.020846363,
-0.025834788,
0.018181494,
-0.00017598964,
-0.019914314,
0.019336708,
-0.021647137,
0.013495,
-0.0059565725,
-0.0307707,
-0.007856769,
0.009937466,
-0.0043911263,
0.009353296,
0.036021676,
0.012457933,
0.0034754877,
-0.0070363036,
0.006498079,
0.013613148,
-0.015201567,
-0.022854859,
0.030901976,
0.014125117,
-0.011637469,
-0.011059862,
0.01584481,
0.010954842,
-0.010232833,
-0.024718955,
-0.0046142926,
-0.02356374,
0.0049818605,
-0.022854859,
0.024928994,
-0.014164499,
-0.0010608606,
-0.029169155,
0.02188343,
-0.012149438,
-0.022710457,
-0.0041252957,
0.01722319,
-0.0004881764,
-0.0046142926,
-0.018023964,
-0.1629902,
0.028328998,
0.012733609,
-0.011591523,
0.026084209,
-0.015017782,
0.0047357213,
-0.0013266911,
-0.009504261,
0.0049096597,
0.019034777,
-0.0048440224,
-0.020570686,
-0.001653236,
0.025519729,
0.0017853308,
-0.0019149642,
0.036678046,
0.004046531,
0.035601597,
0.008033989,
-0.031243289,
0.0022562775,
-0.0016319039,
0.0012323377,
-0.011269901,
0.014742106,
-0.028434018,
-0.010213142,
-0.015739791,
0.0026944054,
-0.00049884245,
0.027593862,
-0.0085065765,
0.02898537,
-0.0046339836,
-0.016750604,
-0.015634771,
0.0061600474,
0.02075447,
0.027515098,
0.011801561,
-0.015936702,
0.018693464,
-0.026517414,
0.039644845,
0.0031358155,
-0.019717403,
0.02806645,
-0.022067213,
0.04011743,
-0.0052837916,
0.0127533,
0.011637469,
0.0069050295,
0.032477267,
0.009261403,
0.008598468,
-0.009418933,
-0.0036001983,
-0.0028831123,
-0.008171827,
0.01835215,
0.01594983,
-0.007909278,
-0.030954486,
-0.003122688,
0.010987661,
-0.02909039,
0.0046897754,
-0.019008523,
-0.010088432,
0.021542117,
-0.027383823,
0.02004559,
0.017249446,
-0.011801561,
-0.01183438,
-0.019573001,
0.011223954,
-0.020491922,
0.021030147,
-0.017472612,
-0.028775332,
-0.019717403,
-0.011112371,
0.02806645,
0.011000788,
-0.0194286,
-0.0107776215,
0.03297611,
-0.016750604,
-0.027777648,
-0.0023022234,
0.018496552,
0.035417814,
0.012582644,
-0.014361411,
-0.014886508,
-0.0075745285,
0.03394754,
-0.019205434,
-0.014033225,
-0.00089840865,
0.01743323,
0.0051426715,
-0.01978304,
-0.014374538,
0.045525935,
-0.025992315,
-0.00014440175,
0.019822422,
0.011630905,
0.011112371,
0.013980716,
0.022356017,
0.019717403,
0.00066334556,
0.018942885,
-0.03809581,
0.07944722,
0.014164499,
-0.0072003966,
0.03788577,
-0.017249446,
-0.0038332103,
-0.1409361,
-0.006990358,
-0.009005419,
0.016251761,
-0.008145572,
0.020373775,
-0.017354466,
0.0006678581,
-0.0157923,
0.022592312,
-0.029484212,
-0.00075728877,
0.003511588,
-0.027646372,
0.0104625635,
0.005021243,
0.006458697,
0.0123791685,
-0.025191542,
0.02100389,
0.006957539,
-0.008184954,
-0.00004553578,
-0.022867987,
0.014899636,
0.03421009,
-0.041955274,
0.01932358,
0.00084589893,
0.01296334,
-0.0025450808,
-0.010245961,
0.040563766,
0.0027764519,
0.0076270383,
-0.0073841806,
0.009215457,
-0.021463351,
0.012917394,
-0.03255603,
-0.024246367,
-0.00453881,
0.00994403,
-0.007607347,
0.0040596584,
-0.0149652725,
-0.031505838,
0.01978304,
0.022959879,
-0.028670313,
-0.02587417,
-0.02699,
-0.020111226,
-0.023747524,
0.01748574,
-0.01722319,
-0.0018903502,
0.022631694,
0.005572595,
0.008191518,
-0.0051229806,
0.014886508,
-0.014400793,
0.0032638079,
0.027226295,
-0.022316635,
-0.004742285,
-0.0041482686,
0.021817792,
-0.029615488,
0.0032342712,
-0.008289973,
-0.0126811,
-0.024298877,
-0.0018723,
0.01188689,
0.011125498,
-0.01999308,
0.0045158365,
-0.017525122,
-0.017196937,
-0.012851756,
-0.004072786,
-0.017774543,
0.021043275,
0.0036133258,
-0.0032687306,
-0.0041942145,
0.011217391,
0.0076007834,
-0.009162948,
0.025677258,
0.0057104332,
0.0021857175,
-0.011053298,
0.00365599,
-0.011913145,
0.013954461,
0.009031673,
0.03184715,
-0.04830895,
-0.0024499071,
-0.041403923,
0.011683415,
0.008401557,
0.017813925,
0.0053789653,
-0.011873762,
0.020557558,
-0.009149821,
-0.010731676,
0.012444805,
-0.02209347,
0.020360647,
0.02183092,
-0.015175312,
-0.025139032,
-0.0059992364,
0.038358357,
-0.0010723472,
-0.00033146766,
0.018234003,
0.0021873584,
0.020071844,
0.008322792,
-0.008349047,
0.004512555,
-0.0032736533,
-0.008191518,
0.022986135,
-0.021975322,
-0.012989595,
-0.009405805,
-0.022618566,
-0.020268755,
0.003006182,
-0.018903503,
-0.022067213,
-0.008801944,
0.023078026,
0.007672984,
0.039487317,
-0.012497315,
-0.029615488,
0.028696567,
0.0035444067,
0.00540522,
-0.012845192,
-0.045315895,
0.0053264555,
0.017065663,
-0.019966824,
0.024128221,
0.0057695066,
0.0051459535,
-0.019179178,
-0.00076344225,
0.014361411,
0.016146742,
-0.017984582,
-0.027331313,
-0.02366876,
0.011985346,
0.03021935,
0.013232452,
0.014046352,
-0.017800799,
-0.0078830235,
-0.031453326,
0.0082046455,
0.020439412,
-0.022566056,
-0.013731294,
0.012923957,
0.010836695,
-0.019034777,
0.01594983,
0.01994057,
-0.030193094,
-0.0019723966,
0.0007429306,
0.021634009,
0.01815524,
-0.008454067,
-0.0054971124,
-0.00011917247,
0.041036353,
-0.0008828198,
-0.01850968,
0.009274531,
0.008421248,
-0.0015777532,
-0.004666802,
0.0081587,
0.0051426715,
-0.005644796,
-0.0035542522,
0.021332078,
-0.010856386,
0.020715088,
-0.0062322486,
0.042244077,
-0.0034328236,
-0.003977612,
0.016330525,
0.0022086904,
-0.030508153,
0.005759661,
-0.014492685,
-0.02372127,
-0.0051459535,
0.023537487,
0.016435545,
0.028407764,
0.01651431,
-0.011978782,
-0.012569516,
0.016684966,
-0.0030307958,
0.00076057063,
-0.001512116,
0.01584481,
0.013796931,
-0.00023855006,
0.008618159,
-0.011276464,
0.0016794909,
0.026018571,
0.010561019,
-0.020373775,
0.0021939222,
-0.020793853,
0.02423324,
-0.009405805,
-0.040616274,
-0.011670288,
-0.0117490515,
-0.0164618,
0.023918182,
0.013232452,
-0.03313364,
0.06269661,
-0.0074760728,
-0.014755234,
0.0004935094,
-0.023379957,
0.018627826,
0.0055791587,
0.020715088,
-0.025296561,
-0.026858727,
0.021594627,
-0.0054216296,
0.0044961455,
-0.04878154,
-0.0110926805,
0.035050243,
-0.01441392,
0.032162208,
0.0013898669,
0.004374717,
0.0021020302,
-0.010482254,
-0.00046561362,
0.017105045,
-0.023484977,
0.0034820514,
0.021095784,
-0.015687281,
-0.0059697,
-0.028591547,
-0.009622408,
-0.0133374715,
-0.030403133,
0.00061083585,
0.01820775,
-0.009353296,
-0.030744446,
-0.01835215,
-0.0104625635,
0.03497148,
-0.021712773,
0.010843259,
-0.010239397,
-0.009871829,
0.00017383591,
-0.009241712,
0.014295774,
-0.013849441,
-0.008821635
] |
The China Health and Retirement Longitudinal Study (CHARLS) is a nationally representative longitudinal survey of persons in China 45 years of age or older and their spouses, including assessments of social, economic, and health circumstances of community-residents. CHARLS examines health and economic adjustments to rapid ageing of the population in China. The national baseline survey for the study was conducted between June 2011 and March 2012 and involved 17 708 respondents. CHARLS respondents are followed every 2 years, using a face-to-face computer-assisted personal interview (CAPI). Physical measurements are made at every 2-year follow-up, | [
0.004749895,
-0.00068828097,
0.020599687,
-0.063036114,
-0.023490636,
0.013022713,
-0.014293386,
0.019523986,
-0.022388041,
-0.0027783357,
-0.027201805,
0.027497623,
-0.02343685,
0.026905987,
-0.0008647633,
-0.00090762327,
0.02332928,
-0.018649977,
0.017049871,
-0.014831237,
-0.029366655,
0.007455957,
-0.00804087,
0.021998098,
-0.01233023,
0.0062995777,
0.017143995,
-0.014737112,
-0.0017412921,
-0.014051353,
0.0029480949,
-0.00645421,
-0.030953316,
-0.047008164,
-0.010750294,
-0.017977664,
0.0059936754,
-0.018649977,
0.013540395,
-0.016538912,
0.003654024,
0.003475861,
-0.0033178674,
0.0022035076,
0.012121813,
0.0037380634,
0.018112127,
-0.032943364,
-0.020922398,
0.01503293,
0.0014437933,
0.016740607,
-0.017870095,
0.008222395,
0.013526948,
-0.0078055602,
-0.018824778,
0.028102705,
-0.019456754,
-0.030765068,
-0.0036170469,
0.0069920607,
-0.0396665,
0.021137537,
-0.02163505,
-0.016256541,
-0.009580468,
0.009553575,
0.019335737,
0.034960303,
0.029017052,
0.012182321,
-0.0064172326,
0.025857178,
0.038456336,
0.00048028398,
-0.008108101,
-0.010360352,
0.0053986777,
0.0037347018,
0.002729593,
-0.021352679,
0.0025127719,
0.0068004513,
-0.0003241812,
0.010447753,
-0.014091692,
0.017749077,
-0.0015858195,
-0.01245797,
0.020828273,
-0.0086997375,
-0.0034422453,
0.017291903,
-0.016095186,
-0.0039027801,
0.016754054,
-0.006370171,
-0.018690316,
-0.008793861,
-0.027309377,
-0.010568769,
-0.019134043,
-0.0052541303,
-0.013849659,
-0.003546454,
-0.017412921,
-0.0015866599,
0.027148021,
-0.0050087357,
-0.008350134,
0.013903444,
0.007213924,
-0.012854635,
0.0022455272,
-0.038698368,
-0.009372051,
-0.0039935424,
0.011597409,
-0.0152211785,
0.030173432,
0.0052070683,
0.015543889,
-0.006713051,
0.007402172,
0.0037817636,
-0.036224253,
-0.014212708,
0.00013803437,
-0.004185152,
-0.028909482,
-0.011947012,
0.018152466,
0.011859611,
-0.019550879,
0.0025245373,
-0.023719221,
0.0042960835,
-0.027672425,
-0.024942832,
0.00015400183,
0.02751107,
-0.011758764,
-0.009425836,
-0.01290842,
0.0062962165,
0.020142514,
0.0113755455,
-0.0158666,
0.01773563,
0.00542557,
-0.017291903,
0.020559348,
0.001803481,
0.008477874,
0.01813902,
0.018475177,
0.03818741,
0.00043154127,
-0.019873587,
-0.0037145324,
0.002480837,
0.0074828495,
0.002791782,
-0.018703762,
0.016565805,
0.0052373223,
0.003437203,
0.012189045,
0.010353629,
0.0025867263,
0.039747175,
-0.018165912,
-0.011039388,
-0.00016933898,
0.010104872,
-0.021097198,
-0.0058121504,
-0.02517142,
-0.011328483,
-0.015140501,
0.023974702,
0.028936375,
0.0068643214,
-0.0068777674,
0.011960458,
0.015274963,
0.019671895,
0.00255143,
-0.015113608,
0.010286397,
0.016740607,
0.0060239295,
-0.040715307,
-0.645421,
-0.014266494,
-0.0077450518,
0.015449765,
0.0056272643,
-0.00555331,
0.008908154,
0.010467921,
-0.026946327,
0.014400956,
-0.0007874472,
0.0070391227,
0.029259086,
-0.012417631,
-0.023705775,
-0.012679833,
-0.013452994,
-0.008114824,
0.019268505,
0.014777452,
-0.013130283,
0.019497093,
0.0025732801,
0.03219037,
-0.018770995,
0.034503132,
-0.0019329014,
-0.026435368,
-0.012464693,
0.01200752,
-0.019066812,
0.023060355,
0.002332928,
0.00795347,
0.03366946,
-0.018797887,
-0.0067298585,
0.027484177,
0.02084172,
0.013728643,
-0.018071787,
0.016565805,
0.009156911,
-0.0028791828,
-0.015301856,
0.0024707522,
-0.008995555,
0.03068439,
0.009936794,
-0.0029346487,
0.009835947,
0.0036473009,
-0.0013353828,
-0.013042883,
0.024418429,
-0.00038300862,
0.015893493,
-0.033373643,
0.008995555,
0.0053381696,
-0.0010563727,
0.014885021,
-0.010636,
-0.0114495,
-0.018663423,
0.032728225,
-0.02783378,
0.026556386,
0.014185816,
-0.0015875003,
-0.006034014,
0.03574019,
-0.010064534,
-0.0005828118,
0.024310857,
0.012209214,
0.0065987576,
0.028129598,
-0.003180043,
0.015678352,
0.013103391,
0.009123295,
0.012679833,
0.01582626,
-0.017856648,
-0.019134043,
-0.0167675,
-0.008746799,
-0.02693288,
-0.007845899,
0.016673375,
-0.01438751,
-0.005270938,
-0.016323773,
-0.00076517684,
0.017036425,
-0.015584228,
0.0047230027,
-0.016054848,
-0.026758078,
-0.022562843,
-0.01957777,
0.013426102,
0.022697305,
0.011308313,
0.018851671,
-0.015732137,
-0.0058692973,
0.046362743,
-0.030980207,
0.015006038,
0.027416946,
-0.012740342,
0.009035894,
-0.014683328,
-0.025588254,
0.0152211785,
0.010299844,
0.028613664,
-0.013163899,
0.029662473,
0.012081474,
0.032082804,
-0.019927373,
0.008356857,
0.021097198,
0.0022253578,
0.02570927,
0.01846173,
-0.0050356286,
0.014965699,
0.004612071,
0.018649977,
-0.016928855,
0.02423018,
0.0026472346,
0.0075702504,
-0.010057811,
-0.006057545,
-0.0062592393,
-0.010925095,
0.008861093,
-0.0007714798,
-0.018179359,
0.014777452,
-0.008329965,
-0.0060541835,
-0.010817525,
-0.014764005,
-0.02772621,
-0.0043028067,
-0.024283964,
-0.0008601411,
0.0059129978,
-0.028129598,
0.008740076,
-0.01709021,
-0.027753104,
-0.009291373,
-0.018945796,
0.0076307585,
0.0086392285,
-0.028425416,
-0.006665989,
0.019376077,
-0.013325254,
0.0130563285,
0.040500168,
-0.016686821,
-0.03861769,
0.002993476,
-0.010158658,
-0.017896986,
0.034906518,
-0.0056440723,
0.010662893,
-0.010669616,
0.0016891877,
0.0012345357,
-0.023974702,
-0.0015925427,
0.008235841,
-0.013103391,
-0.02909773,
0.009351881,
0.0077652214,
0.013009267,
0.0011656235,
0.004780149,
0.024862155,
-0.01640445,
0.035040982,
-0.013943783,
0.015597674,
0.009701485,
0.0065819495,
-0.014898468,
-0.0023278857,
0.040500168,
-0.023678882,
0.005002013,
-0.0014891744,
0.010367075,
-0.004017073,
0.01020572,
0.007644205,
-0.0013227769,
0.0010084703,
0.008007254,
0.021836745,
0.0031615545,
-0.017009532,
-0.029608687,
-0.0072340937,
-0.016606145,
0.01698264,
0.0029833913,
-0.0054457397,
0.00026913552,
0.021688836,
0.0008605613,
-0.010878033,
0.024458766,
-0.01734569,
-0.01860964,
0.012289892,
0.004891081,
0.018327268,
0.0028422056,
0.0066827964,
-0.02015596,
-0.0041078357,
0.018784441,
0.018770995,
0.0014101777,
0.015584228,
0.019954266,
-0.027484177,
0.005139837,
0.013876552,
-0.003986819,
0.009795608,
0.020465225,
-0.021971207,
-0.002643873,
-0.010360352,
0.021581264,
0.016565805,
-0.0047566183,
0.0019866866,
-0.0018858395,
0.04824522,
-0.019819804,
-0.008961939,
-0.0070122303,
-0.00628277,
0.017964218,
0.014118585,
0.010447753,
0.020935843,
0.025292436,
0.014414403,
-0.017076764,
0.0070189536,
0.017722186,
-0.004487693,
-0.014992592,
-0.0021211493,
-0.010434306,
-0.027887566,
0.004269191,
-0.004827211,
-0.0042859986,
-0.039935425,
0.0028892674,
0.007045846,
0.022522504,
-0.01582626,
0.008948493,
0.006235708,
-0.0106830625,
-0.024216734,
-0.0001359334,
0.021581264,
-0.023100693,
-0.027618641,
-0.0018757548,
0.020424886,
-0.005523056,
-0.0028808636,
-0.0026842118,
0.0071803085,
0.00061684765,
0.012061305,
-0.009983856,
0.00027417787,
0.004198598,
-0.012343677,
0.011637747,
0.011920119,
0.017520491,
-0.01085114,
-0.009916625,
-0.045851782,
0.01368158,
0.012901696,
-0.031195348,
-0.008686291,
-0.011980628,
-0.0037044475,
0.015449765,
-0.02339651,
-0.025104187,
-0.0023346087,
0.022253579,
0.018784441,
-0.01687507,
0.008894708,
0.0247008,
-0.019645002,
0.0013446271,
-0.053677514,
-0.05166057,
0.006665989,
0.08804618,
0.019268505,
0.010279674,
-0.0030388571,
-0.0009277927,
-0.023947809,
0.01518084,
-0.03829498,
0.01413203,
0.013782428,
-0.018112127,
-0.012141982,
0.015947277,
0.017426368,
0.003413672,
0.02909773,
0.022280471,
-0.017681846,
-0.0072273705,
0.016794393,
-0.010461199,
-0.021460248,
0.036466286,
0.0584106,
-0.0019513901,
-0.008074486,
-0.00066895195,
-0.011859611,
0.0071601393,
-0.017789416,
-0.008256011,
0.01889201,
-0.01824659,
0.03345432,
-0.01370175,
0.027322823,
0.0019362629,
0.0032388705,
0.015463212,
0.0006487826,
0.010151935,
-0.00071475335,
0.011025942,
-0.012552094,
0.012733619,
-0.0008324082,
0.004961674,
0.022320809,
-0.004827211,
-0.009553575,
0.030307895,
-0.0057314727,
-0.018125573,
-0.018811332,
-0.0011572196,
0.009640976,
-0.009291373,
-0.03006586,
0.007099631,
-0.021487141,
-0.022777982,
-0.025722716,
0.017278457,
-0.008666121,
-0.020922398,
-0.0053011924,
-0.017022979,
-0.0045515625,
0.004205321,
-0.0014883342,
0.006944999,
-0.0072340937,
-0.008840923,
0.013822766,
-0.010481368,
-0.034825843,
0.025978195,
0.0071399696,
-0.020882059,
-0.0037347018,
-0.011604132,
0.0041548978,
-0.012632771,
-0.015449765,
-0.004215406,
0.022024991,
0.0016412854,
-0.013742088,
0.0053415312,
0.014535419,
-0.004215406,
-0.017399475,
0.020129068,
-0.006531526,
-0.017372582,
-0.010131765,
0.017829755,
0.021177877,
-0.029393548,
-0.014091692,
0.0062491545,
-0.028909482,
-0.012989097,
-0.020962736,
0.008908154,
-0.013943783,
-0.008504766,
-0.014414403,
-0.020223191,
-0.020586241,
0.02033076,
-0.044292018,
0.015664905,
-0.0033380368,
-0.006128138,
0.005365062,
0.0029480949,
0.024162948,
0.032647546,
-0.018192803,
0.0042490214,
0.0081282705,
0.006471018,
0.02332928,
-0.03799916,
0.017789416,
0.0004281797,
-0.0014353894,
-0.030173432,
-0.01824659,
0.013110114,
0.007798837,
-0.01640445,
-0.032082804,
-0.026193336,
0.011288145,
-0.032539975,
0.0038691645,
0.0023749475,
-0.0037515096,
-0.015893493,
-0.008061039,
0.005257492,
0.0011294867,
0.047169518,
-0.025763055,
-0.0009832586,
-0.0026152998,
0.017910432,
0.019994605,
0.0040607736,
-0.0014328682,
-0.0015572462,
0.014911914,
0.011926842,
-0.0005798704,
-0.008417365,
-0.016175864,
0.029501118,
-0.0024455404,
0.037515096,
-0.0028422056,
0.008484597,
0.008047593,
0.00510286,
-0.004322976,
-0.028156491,
-0.010219166,
-0.0060844375,
0.019134043,
0.0059365286,
0.020935843,
-0.01687507,
-0.0025598337,
-0.0065819495,
0.009163634,
0.00087989034,
-0.031033993,
-0.021366125,
-0.0540809,
-0.024001593,
-0.018555854,
0.0017412921,
0.007603866,
-0.030012077,
-0.012068028,
0.011731871,
-0.008350134,
0.017601168,
0.002729593,
0.004877635,
-0.023490636,
0.025628593,
-0.034879625,
-0.008081209,
-0.013997568,
-0.0025480683,
-0.022549396,
0.00076643744,
0.018125573,
0.00057566847,
0.03407285,
0.02332928,
-0.015140501,
0.02347719,
-0.0013673176,
-0.021325786,
-0.006336555,
0.0013505098,
-0.012128537,
0.008269456,
-0.019591216,
-0.008464428,
-0.029877614,
-0.0073147714,
0.01108645,
-0.014642989,
0.037837807,
-0.01222266,
-0.00006870204,
-0.014441295,
0.016552359,
0.022051884,
-0.001944667,
0.039612714,
0.013560564,
-0.022656966,
-0.021393016,
0.022509057,
0.02030387,
-0.005714665,
0.023853684,
0.015530443,
-0.028290953,
0.007583697,
0.029339762,
0.028748127,
-0.03334675,
-0.04095734,
0.0127268955,
0.014885021,
-0.0011067962,
-0.009936794,
-0.012047859,
-0.027806887,
0.005529779,
0.0026539578,
-0.035525046,
0.018327268,
-0.009022447,
0.0038120179,
0.022240132,
-0.037084814,
-0.00859889,
0.0089686625,
-0.022388041,
-0.0054625473,
-0.026879095,
-0.001927859,
0.0009202292,
0.008020701,
0.029124623,
-0.0074895727,
-0.008894708,
0.0081282705,
0.022845214,
-0.006871044,
0.0020186214,
-0.024687354,
0.032136586,
-0.01773563,
-0.0070256763,
0.0022455272,
0.0009454409,
0.023961255,
0.0011563792,
-0.0034422453,
-0.0059768674,
-0.02390747,
-0.022320809,
0.043296993,
0.01290842,
0.0030354955,
-0.01155707,
-0.010844418,
-0.008329965,
-0.0034523301,
0.001803481,
0.014790898,
-0.0035834312,
-0.014414403,
0.0021379571,
0.00005115886,
0.019604662,
0.0012026009,
-0.007556804,
-0.0046053478,
0.012538647,
-0.033050932,
0.020640025,
0.0021379571,
0.0017017936,
-0.027591748,
0.022603182,
-0.0033245904,
-0.024216734,
0.007388726,
-0.004205321,
-0.03407285,
-0.05491457,
0.02073415,
0.023692328,
0.010326736,
0.009459452,
0.011160404,
0.0023833516,
0.0055398634,
-0.010441029,
-0.017789416,
0.020572795,
-0.015113608,
0.018381052,
0.006471018,
-0.013110114,
0.03883283,
-0.032943364,
0.020505562,
0.009667869,
-0.02354442,
-0.016243095,
-0.0049885665,
-0.012753787,
-0.009466175,
0.008101379,
-0.057603825,
0.001990048,
-0.011187297,
0.03375014,
-0.008820754,
-0.0035330076,
0.018730655,
0.0015883407,
0.023894023,
0.015638012,
0.014414403,
0.012713449,
-0.0065752263,
0.018582746,
-0.023719221,
0.0032993788,
-0.009378774,
0.03595533,
0.03915554,
-0.0060743527,
-0.03493341,
-0.013137006,
-0.046712346,
-0.014683328,
-0.0028909482,
0.031894553,
-0.00975527,
0.002791782,
0.025534468,
0.032620654,
0.012599155,
0.026354691,
-0.021917421,
-0.017412921,
0.010427583,
-0.014750559,
0.0122764455,
0.003801933,
-0.023826791,
0.009452729,
0.03418042,
0.012162152,
-0.026892541,
0.019187829,
0.0048036803,
-0.0067063277,
0.010017471,
-0.012578987,
-0.021272,
-0.017507045,
0.006608842,
-0.018703762,
0.017856648,
0.0011479753,
-0.012538647,
0.0013303404,
0.0049415044,
-0.012081474,
0.0038052946,
-0.0033111442,
-0.008659398,
-0.022616627,
-0.013594179,
-0.003522923,
0.010642723,
0.0062189004,
0.029850721,
0.034530025,
0.0045582857,
-0.010192273,
-0.011274698,
0.0030825576,
-0.015315303,
-0.005761727,
0.0050289053,
-0.015248071,
0.013822766,
-0.013500056,
-0.026663955,
0.0043733995,
-0.0127268955,
-0.032324836,
-0.018219696,
-0.021110645,
0.02963558,
0.013641242,
-0.015947277,
0.016686821,
-0.0011219232,
-0.020142514,
-0.011617578,
0.0033077826,
0.0034523301,
-0.051068936,
0.027672425,
0.012431078,
-0.0078122835,
0.011308313,
0.0081282705,
-0.010481368,
-0.003956565,
0.017681846,
0.21557061,
0.004534755,
0.016095186,
0.019725678,
-0.023504082,
0.029124623,
0.030254109,
0.02339651,
-0.021729173,
0.030415464,
-0.01539598,
0.011812549,
-0.01346644,
0.011725148,
-0.0015597674,
-0.025843732,
-0.00088829425,
-0.00095972756,
0.016848177,
-0.008652675,
0.001959794,
-0.0010320013,
-0.028129598,
-0.038456336,
0.0056743263,
0.013170622,
-0.014360617,
-0.016350666,
0.012572263,
0.012733619,
-0.012410908,
-0.018085234,
-0.004954951,
-0.010259504,
-0.018421391,
-0.0072677094,
0.00379521,
-0.0022371232,
0.009856117,
0.02257629,
0.0037683174,
0.0065147183,
0.005247407,
-0.019322291,
0.032082804,
0.006615565,
-0.009439282,
-0.017722186,
-0.00904934,
0.0014488357,
-0.032862686,
0.0005315479,
0.0051667294,
0.03399217,
0.001974921,
0.01582626,
0.040984232,
-0.009217419,
-0.021352679,
0.0038086562,
0.0017110379,
0.0069248294,
-0.0066122035,
-0.012370569,
-0.0042658295,
0.02427052,
-0.0031901277,
-0.02033076,
-0.010582215,
-0.005630626,
0.000099849065,
-0.012451246,
-0.009486344,
-0.0034069489,
-0.025978195,
-0.017695293,
0.03579397,
0.02159471,
0.021540925,
0.03807984,
-0.016283434,
-0.0010941903,
-0.026300905,
0.022724198,
-0.015046377,
-0.020586241,
0.024687354,
0.008155163,
-0.021540925,
-0.0007979521,
0.0037750406,
-0.0022589734,
-0.0070122303,
0.014535419,
0.03046925,
0.011120066,
-0.0003233408,
0.006323109,
-0.010736847,
-0.005523056,
-0.04474919,
0.054780107,
-0.0018757548,
0.0013345424,
0.0005857532,
-0.015893493,
-0.021406462,
0.005200345,
-0.008417365,
-0.005180176,
-0.0061752,
-0.026758078,
0.006608842,
-0.009298096,
-0.0088342,
0.013600903,
0.011120066,
-0.029285979,
0.019806357,
-0.021393016,
-0.01593383,
-0.024391536,
-0.004454077,
0.03313161,
-0.014011014,
-0.026838757,
-0.0062222616,
-0.03036168,
-0.0053617004,
-0.010535154,
0.0007807241,
-0.037326846,
-0.0031279388,
-0.0073147714,
-0.008753522,
-0.0019614748,
-0.008693014,
-0.0066996044,
-0.020519009,
-0.0075231884,
-0.018313821,
-0.009573745,
-0.013607626,
-0.011906673,
0.011624301,
-0.0028472478,
-0.006400425,
0.027672425,
-0.0058827433,
-0.02613955,
-0.021352679,
0.011469669,
0.014091692,
-0.02354442,
0.038590796,
-0.024512552,
-0.019887034,
-0.003459053,
0.013695027,
0.012088197,
0.0043196143,
-0.020707257,
0.041629653,
0.008773692,
-0.011402437,
-0.002884225,
-0.1712517,
0.019053366,
0.0063970634,
-0.027672425,
0.0017135591,
0.01756083,
0.001314373,
0.009788885,
-0.0031699582,
0.012894974,
0.024162948,
0.009439282,
-0.044265125,
-0.008222395,
-0.002139638,
0.0072677094,
-0.023961255,
0.014642989,
0.034234207,
0.009667869,
0.023383064,
-0.022361148,
0.015584228,
0.017224673,
0.013997568,
-0.0047835107,
0.018959241,
0.00971493,
-0.017802862,
-0.007906407,
-0.018179359,
0.0041649826,
0.011422607,
-0.0071803085,
-0.009593914,
0.0023295665,
-0.016619591,
-0.018865118,
-0.018515514,
0.0077719446,
0.014454741,
0.030092753,
-0.004954951,
-0.003889334,
0.002185019,
0.036950354,
0.015624567,
-0.024041932,
0.010044364,
-0.027591748,
-0.00611133,
-0.006020568,
0.04921335,
0.002613619,
0.006763474,
0.0067870053,
-0.017332243,
0.01734569,
0.00056768476,
0.016861623,
-0.012982374,
0.002448902,
-0.005002013,
-0.016794393,
0.028183384,
-0.014226154,
-0.0016757415,
-0.01417237,
0.009062787,
0.015234625,
0.0008429131,
-0.009990579,
0.006323109,
-0.012370569,
0.048433468,
0.007455957,
-0.0073820027,
-0.0014832917,
0.017063318,
-0.027201805,
0.0107435705,
0.012437801,
-0.029393548,
-0.012108367,
-0.016713714,
0.0018236504,
0.00849132,
0.0041683437,
0.023087246,
-0.015947277,
-0.0029531373,
-0.032002125,
0.0006559259,
-0.008276179,
-0.00795347,
0.007563527,
-0.023517529,
-0.006944999,
-0.0011261252,
-0.022159453,
0.0077450518,
-0.014548865,
0.01020572,
0.014911914,
-0.013069775,
-0.016915409,
-0.015140501,
0.013137006,
0.026005087,
-0.0067970897,
-0.017856648,
0.009829224,
0.02401504,
0.012901696,
0.002774974,
0.030092753,
-0.028102705,
-0.009452729,
0.0020791297,
-0.004665856,
0.019389523,
-0.0050759674,
0.0068172594,
0.011785656,
0.009506513,
0.00283044,
-0.10832316,
-0.0023211625,
-0.0028758212,
0.033588786,
0.033884604,
0.020182852,
0.0021766152,
-0.005872659,
-0.01940297,
0.019456754,
-0.0009664507,
-0.0072273705,
-0.0048944424,
-0.00093955814,
0.044157553,
-0.039612714,
0.0040708585,
-0.019456754,
0.0056239027,
0.020505562,
-0.012249553,
-0.037380632,
0.023100693,
-0.026126103,
0.021661943,
0.00095216406,
-0.028506095,
0.023154479,
0.011967181,
0.005328085,
-0.022347702,
-0.006188646,
-0.007153416,
-0.0004078002,
0.013526948,
-0.016471682,
-0.020720704,
0.0017043148,
0.026448814,
-0.036788996,
0.029662473,
0.01597417,
0.013621072,
-0.02783378,
0.02026353,
-0.013889998,
0.012451246,
0.0063567245,
0.006034014,
-0.016861623,
0.0029817105,
-0.0024791562,
-0.014414403,
0.0014320278,
0.017399475,
-0.017359136,
0.013170622,
0.0012681514,
-0.012229383,
-0.010286397,
-0.008262733,
0.0052137915,
-0.046846807,
0.0015849791,
0.013224407,
-0.009701485,
-0.0077652214,
0.0059129978,
0.0072340937,
0.0013841256,
-0.028425416,
0.013076498,
-0.012182321,
0.013372316,
-0.026516046,
-0.0027951435,
0.0043969303,
0.002628746,
0.003825464,
-0.006040737,
0.0063163857,
-0.011953735,
0.001275715,
-0.015759028,
0.027753104,
-0.00084711506,
0.0052440455,
-0.01503293,
0.008666121,
-0.015127054,
0.027215252,
0.028532987,
0.0011874738,
-0.013284915,
0.019752571,
0.006501272,
-0.022656966,
-0.009398944,
-0.0038153792,
0.0014009334,
-0.021339232,
-0.023288941,
-0.062982336,
0.012814296,
0.02026353,
-0.0008235841,
-0.022899,
-0.0015933831,
0.026368137,
-0.008256011,
-0.014441295,
0.002541345,
-0.0156111205,
0.0353368,
-0.007402172,
0.024216734,
-0.04878307,
-0.01899958,
0.010662893,
0.0047532567,
0.036762103,
0.0292053,
0.026731186,
0.007940023,
0.037730236,
-0.0012799168,
0.01370175,
0.0016085102,
-0.0057415576,
0.034503132,
-0.026099212,
-0.021890529,
0.004914612,
-0.007926577,
0.00795347,
0.008182056,
0.00362377,
-0.03885972,
0.017063318,
0.016216202,
0.026596723,
0.01438751,
0.004712918,
-0.013190792,
0.011207467,
-0.0018858395,
-0.018313821,
0.025534468,
-0.0029279254,
0.017184334,
0.013284915,
0.002526218,
0.013836212,
-0.0035363692,
0.001610191,
-0.017574277,
0.017022979,
0.003413672,
0.0002813212,
-0.006568503,
-0.0059667826,
-0.01687507,
0.03418042,
0.017574277,
0.020209745,
0.010219166,
-0.014454741,
-0.03036168,
-0.008545105,
-0.0107435705,
-0.0119133955,
-0.03587465,
-0.026650509,
0.012888251,
0.013291638,
0.01730535,
-0.0023816708,
0.0038725259,
-0.033185396,
-0.01582626,
-0.007153416,
-0.0014370702,
0.008645952,
0.014764005,
-0.011893227,
0.007940023,
0.024875602,
0.028748127,
-0.01213526,
0.01348661,
0.0022673775,
-0.009459452,
0.006070991,
0.0132513,
0.0018337352,
-0.0020118982,
-0.008329965,
0.028694343,
0.002052237,
0.0016816242,
0.025547914,
0.005412124,
0.0004479289,
0.013331978,
-0.026152996,
-0.031437382,
-0.002395117,
0.0022925893,
-0.015261517,
0.010286397,
-0.008370304,
0.01108645,
0.01618931,
0.02866745,
-0.00145808,
0.020519009,
0.0037347018,
-0.005375147,
-0.013029437,
-0.0009446005,
0.00082736585,
0.028129598,
0.01370175,
0.012632771,
-0.0052037067,
0.021137537,
0.007281156,
0.0077853906,
0.019322291,
0.008195502,
-0.004067497,
-0.007825729,
-0.0029127984,
-0.01370175,
-0.034099743,
-0.016619591,
-0.017386029,
-0.008753522,
0.013526948,
0.0016412854,
-0.019013027,
0.061960414,
0.016552359,
-0.015960723,
0.016700268,
0.018797887,
0.038052946,
0.0062794085,
-0.003986819,
-0.022899,
-0.014441295,
0.008874538,
-0.038913507,
-0.017480152,
-0.025440345,
-0.011758764,
0.011967181,
-0.009298096,
0.025252096,
0.00047230025,
-0.0151001625,
-0.0036036007,
-0.020088729,
0.023423404,
0.006437402,
-0.008726629,
-0.0020774489,
0.01507327,
-0.014158923,
0.0041717053,
-0.0024522636,
0.003117854,
0.034045957,
-0.029608687,
0.00538187,
0.02729593,
-0.0033716524,
0.015449765,
-0.013190792,
0.004820488,
0.003980096,
-0.0009479621,
0.011886504,
-0.0031598737,
-0.003289294,
-0.02152748,
-0.0093922205,
0.004322976,
-0.0123504,
-0.008316519
] |
OBJECTIVE Multiple sclerosis (MS) is a disease of the central nervous system with marked heterogeneity in several aspects including pathological processes. Based on infiltrating immune cells, deposition of humoral factors and loss of oligodendrocytes and/or myelin proteins, four lesion patterns have been described. Pattern II is characterized by antibody and complement deposition in addition to T-cell infiltration. MS is considered a T-cell-mediated disease, but until now the study of pathogenic T cells has encountered major challenges, most importantly the limited access of brain-infiltrating T cells. Our objective was to identify, isolate, and characterize brain-infiltrating cl | [
-0.037354294,
0.028560415,
-0.01120235,
-0.03024044,
-0.015500851,
0.01479209,
-0.018952776,
-0.012711748,
-0.031369206,
-0.0115501685,
0.010861096,
0.019359658,
-0.0041934988,
0.022706581,
-0.008833254,
0.024242228,
0.042998128,
0.021223433,
-0.0031943433,
-0.007816051,
-0.03551677,
0.005210701,
0.0055913315,
-0.012928314,
-0.012048925,
0.0010352494,
0.009706079,
-0.05790834,
0.008754502,
0.009745454,
0.0012272054,
-0.031526707,
-0.01959591,
0.0002789103,
0.0044264705,
-0.017771509,
0.008413248,
0.0033206732,
0.0112286005,
0.0093320105,
0.011307352,
-0.0038095866,
-0.006172121,
0.0076716742,
0.017325252,
0.0056766453,
-0.020974055,
-0.011097349,
-0.019372782,
0.023585968,
0.036698036,
0.0042295926,
-0.019044653,
0.012442681,
-0.024780361,
-0.03234047,
-0.00042615854,
0.003757086,
0.01067078,
-0.033364236,
0.0016373675,
-0.008531374,
-0.0030598103,
-0.011484542,
-0.004111466,
0.009528888,
-0.018493393,
0.006949789,
-0.016130859,
-0.000011670397,
0.021538438,
0.04305063,
-0.016734619,
0.009181071,
0.025830377,
-0.008944818,
-0.012462369,
-0.012022675,
-0.00021984694,
0.0015356473,
0.039900582,
-0.020869054,
-0.008432935,
0.031867962,
0.021052806,
0.010952972,
-0.010329525,
0.028639168,
-0.0029137924,
0.0034584878,
0.0025052708,
-0.008859504,
0.014070204,
0.01029015,
-0.014201457,
0.019832164,
0.0029236362,
0.03357424,
0.00300895,
0.0015528742,
-0.00012284359,
0.012888937,
-0.027169146,
-0.019477783,
-0.05339328,
0.0030975451,
0.0034388,
0.014057079,
0.028376663,
-0.0026086317,
-0.004180373,
0.018926525,
-0.005673364,
-0.03556927,
0.00791449,
0.028271662,
0.020514674,
-0.012344242,
-0.009318885,
-0.0025807407,
0.006047432,
0.0047972575,
0.00498101,
-0.027037894,
0.010532966,
0.016314613,
-0.027904157,
-0.010985785,
-0.00016744873,
-0.0020065135,
0.0074222954,
0.020291544,
0.007993242,
-0.0039080256,
0.005177888,
-0.002429801,
-0.019254655,
0.002144328,
-0.020921554,
-0.03774805,
0.013269568,
0.030975452,
0.0012977533,
0.0013149801,
0.011372978,
0.013847076,
0.036986787,
0.008301684,
-0.0025725374,
-0.00062590756,
-0.008636376,
-0.040819343,
0.004111466,
-0.014201457,
0.01861152,
0.025961628,
0.00386865,
0.051161993,
-0.0046463176,
-0.035306763,
-0.006943226,
0.005322265,
-0.007625736,
0.00029593206,
0.0060113375,
0.020842804,
-0.012692059,
0.00844606,
0.0012862687,
0.0029088706,
-0.009384512,
0.03286548,
-0.0060441503,
0.009220446,
0.002877698,
0.0003830915,
0.011182663,
0.02743165,
-0.036855537,
-0.024334105,
0.0050302297,
0.013912703,
0.0065429076,
-0.019635286,
-0.010172023,
0.022312826,
0.03580552,
-0.012173614,
0.001686587,
-0.0012468932,
0.019530285,
0.017049624,
-0.018834649,
-0.03499176,
-0.63042915,
-0.018690271,
0.0049941353,
0.00963389,
0.0010688828,
0.022969084,
0.004462565,
-0.015697729,
0.0022280011,
0.014883966,
-0.0149233425,
0.016262112,
-0.00824262,
-0.0051647625,
-0.013368007,
-0.019504033,
-0.02748415,
-0.020803427,
-0.004278812,
-0.005463361,
-0.00308442,
-0.006831662,
-0.0095420135,
0.019635286,
-0.02571225,
0.011405791,
-0.001109899,
-0.013742075,
0.0021049525,
0.02505599,
-0.022234073,
0.022772206,
-0.015356474,
-0.010736406,
0.04522941,
0.0108085945,
-0.007927615,
0.014883966,
0.008511687,
0.014805215,
-0.0043116254,
-0.010060459,
0.0013814264,
-0.031684212,
0.010198274,
0.03365299,
-0.019202154,
0.0019556535,
0.002172219,
-0.007369795,
0.028717918,
0.016524615,
-0.012396743,
-0.0061885277,
0.026460385,
-0.0016833057,
0.0045445976,
-0.015330223,
0.021656565,
-0.01064453,
-0.014227707,
0.01114985,
-0.018834649,
-0.033390485,
-0.028429164,
-0.007448546,
-0.04740819,
-0.022207823,
0.009509201,
-0.0046200673,
0.0110185975,
0.02136781,
0.005555237,
0.0023920662,
0.015395849,
0.017141499,
0.0154746,
-0.008295121,
-0.013847076,
0.0025708969,
-0.020239044,
-0.018860899,
-0.022877209,
-0.015566477,
0.019254655,
-0.01651149,
0.004918665,
0.016708368,
-0.008465748,
0.015225221,
0.012048925,
0.012613309,
-0.006575721,
-0.045465663,
-0.015408974,
0.029899186,
-0.0035536455,
0.011025161,
0.004790695,
0.0062443097,
0.0069038505,
0.008098243,
0.013742075,
0.0013625589,
0.025213491,
0.029190425,
-0.023585968,
0.01926778,
0.041108098,
-0.0030204346,
0.025121616,
-0.006457594,
-0.007107291,
-0.000016291131,
0.014319584,
-0.020488422,
0.005584769,
0.005345234,
-0.007021977,
0.0025036302,
0.025305368,
-0.002981059,
-0.009371387,
-0.0046988185,
0.001906434,
-0.0044363146,
-0.004761163,
-0.018677147,
0.0000045854854,
-0.011241727,
-0.015080844,
-0.017981512,
0.02292971,
-0.023782846,
0.012711748,
0.00720573,
0.023638468,
-0.0027119927,
-0.006467438,
-0.03759055,
-0.020711552,
-0.027694153,
0.008301684,
-0.009981708,
-0.008892317,
-0.0076126107,
-0.01863777,
-0.009377949,
-0.003461769,
0.0012313069,
-0.00083878177,
-0.0070285397,
0.0027201958,
0.02470161,
0.012928314,
-0.007658549,
-0.015251472,
-0.022824707,
0.006434625,
-0.018808398,
-0.024110977,
0.015815856,
0.008629813,
0.011569856,
-0.0043477197,
-0.03727554,
-0.014201457,
0.021354686,
-0.016983997,
-0.031736713,
-0.001929403,
0.0010910315,
-0.0075994856,
0.016340863,
0.009220446,
0.005597894,
-0.009299198,
-0.0128167495,
-0.0031730148,
0.00308442,
0.008820129,
0.01992404,
0.006588846,
-0.01013921,
0.021420311,
-0.0044363146,
0.044494398,
0.011057974,
-0.001976982,
0.036173027,
0.031789213,
0.025423495,
-0.02502974,
0.012258928,
-0.002523318,
-0.015461475,
0.0024150352,
-0.0076716742,
0.011405791,
0.019740287,
0.020396547,
-0.028324163,
-0.0033239545,
-0.0015454913,
0.029032923,
-0.047880698,
-0.0055519557,
-0.026565386,
0.030660447,
-0.0042722495,
0.0039277133,
-0.005699614,
0.0104870275,
-0.018900275,
0.009968583,
0.01120235,
0.01577648,
0.0047119437,
-0.010001396,
-0.009469826,
-0.019753413,
0.021157809,
0.011622356,
-0.0100670215,
0.00472835,
0.036146775,
0.012993939,
0.01716775,
0.020842804,
0.0014905295,
0.0013994735,
0.0018063544,
0.026985392,
0.01097266,
-0.00252824,
0.02472786,
-0.0016455709,
-0.011090786,
0.042761873,
-0.008872629,
0.009660141,
0.03654053,
-0.00035335476,
0.0009909519,
0.0010081787,
-0.03155296,
0.024163477,
-0.0022230793,
0.010762657,
0.013938953,
-0.029374177,
-0.019937165,
-0.009259822,
-0.007172917,
-0.0071466663,
-0.012967689,
-0.0033108294,
-0.0005524885,
0.03354799,
0.032681726,
0.02887542,
-0.03556927,
0.0008022773,
-0.0073894826,
0.0066052526,
-0.013873327,
-0.0068907253,
-0.012632997,
0.0017751821,
-0.016248986,
-0.028744169,
-0.014555837,
0.0154483495,
-0.018296516,
0.004826789,
0.020711552,
0.016970873,
0.021499064,
0.011117036,
0.017745258,
-0.022457201,
-0.013289256,
-0.0024133944,
0.012803623,
-0.013715825,
0.004360845,
-0.00094747473,
-0.02338909,
0.0034322375,
-0.016760869,
0.016852746,
0.0145033365,
-0.010867658,
0.008117931,
-0.025121616,
0.0064608753,
0.037879303,
-0.011871736,
-0.00014140342,
-0.019464659,
0.0048103826,
-0.021354686,
-0.010132647,
-0.003195984,
0.016262112,
0.018769024,
-0.01408333,
0.009587952,
0.0019753412,
-0.006050713,
0.02139406,
-0.03436175,
-0.013833951,
0.019149654,
0.009994833,
0.018139014,
0.019989666,
0.0067791613,
0.021499064,
0.016025858,
0.003383018,
-0.046200674,
0.0035438016,
-0.0069169756,
0.01924153,
0.025830377,
-0.024609733,
0.02139406,
0.0043378756,
0.005827585,
-0.002710352,
-0.02947918,
0.027379148,
-0.011051411,
-0.015920857,
0.0037866177,
-0.001079547,
0.01689212,
0.01861152,
0.031841714,
0.008505124,
-0.021446561,
-0.002869495,
0.013308944,
0.010985785,
-0.0134401955,
0.012501745,
0.025292244,
0.025449745,
-0.00821637,
-0.0048825713,
0.0018506519,
0.0067266603,
-0.03144796,
-0.02093468,
0.018217765,
0.0012977533,
0.00019574992,
-0.010434527,
-0.016038984,
-0.008957943,
-0.0036094275,
-0.0058243037,
0.007304169,
0.014897092,
0.0097520165,
0.003107389,
0.009056382,
0.009515763,
-0.005729146,
0.0137552,
0.007606048,
0.0024330823,
-0.017049624,
-0.0041705295,
-0.018125888,
-0.00227558,
-0.027326647,
0.00044010405,
0.0011263054,
-0.003822712,
-0.012048925,
-0.0048136637,
-0.0023789408,
-0.014910217,
-0.023809096,
0.013368007,
-0.017194001,
-0.031316705,
-0.012245803,
-0.014070204,
0.0012600183,
-0.02025217,
-0.007907928,
0.01850652,
-0.02298221,
-0.027169146,
0.011845485,
0.0011435322,
0.015408974,
0.01476584,
-0.020567175,
0.014070204,
0.027877906,
-0.020645926,
-0.00083632075,
0.020567175,
-0.016826496,
0.019031527,
0.023809096,
0.009469826,
-0.019661536,
-0.016590241,
-0.00086052035,
0.010093272,
-0.028376663,
-0.013558323,
0.033469237,
-0.0030171534,
0.013833951,
0.023743471,
0.03759055,
-0.016025858,
-0.025174117,
-0.016288362,
-0.024819735,
-0.005939149,
-0.032366723,
0.0014396694,
-0.045098156,
0.0056077377,
-0.0058144596,
-0.00061073154,
-0.025331618,
0.001789948,
-0.012790498,
0.03572677,
-0.0075010466,
0.013308944,
0.011957049,
0.015632102,
0.021709066,
0.03575302,
-0.008656063,
-0.0056143003,
-0.0033321579,
0.031159203,
-0.005332109,
-0.029820435,
0.0037997428,
0.005519143,
-0.019123403,
-0.027930407,
-0.036908038,
0.00036094277,
0.036881786,
-0.013610823,
-0.01916278,
-0.016419614,
0.007186042,
-0.007770113,
0.033311736,
-0.0035634893,
-0.010080147,
0.0018506519,
0.014529587,
-0.034860507,
-0.004948197,
0.033127982,
-0.03562177,
-0.0069169756,
0.019110277,
-0.0049941353,
0.024347229,
0.005364922,
-0.0006841506,
-0.010900471,
0.008045742,
-0.017338376,
-0.016721493,
0.006323061,
-0.017627131,
0.036146775,
0.031080453,
0.019202154,
-0.0074091703,
0.015303973,
-0.0015290848,
-0.0022280011,
0.020317797,
0.0021131558,
-0.0006779982,
-0.008334496,
0.008682314,
0.006844787,
-0.010473902,
0.022798456,
-0.06940601,
0.024347229,
0.028245412,
-0.0074222954,
-0.016170235,
-0.024281604,
-0.040793095,
-0.011222038,
0.034624252,
-0.0030630915,
0.02022592,
-0.037958052,
-0.0071466663,
0.0050761676,
0.007297606,
0.01921528,
0.004341157,
0.02470161,
-0.010126085,
-0.008833254,
-0.014595212,
0.0005073707,
-0.009587952,
0.012403306,
0.0041278726,
-0.007645424,
0.01678712,
0.010158898,
-0.0048956964,
0.0061360267,
-0.004442877,
0.021722192,
0.013000501,
-0.025384119,
-0.014647713,
-0.018729648,
-0.018769024,
-0.024793485,
-0.002032764,
-0.03354799,
-0.01823089,
0.01061828,
0.0092270095,
-0.014555837,
0.018099638,
-0.036015525,
-0.016577117,
0.021604065,
-0.033337984,
0.021866567,
-0.018257141,
0.012987376,
0.032550473,
-0.0033600489,
-0.016590241,
0.023205338,
-0.025633499,
-0.0054797675,
0.04278812,
0.004935072,
0.012094864,
-0.018034013,
0.011143288,
-0.019635286,
0.003274735,
-0.02892792,
0.020068416,
0.03218297,
-0.008006367,
-0.018335892,
-0.019779664,
-0.021604065,
0.017404003,
-0.028429164,
-0.019477783,
-0.009200759,
-0.012862687,
-0.020134043,
0.03213047,
-0.024806611,
0.009679829,
-0.0039474014,
-0.018952776,
-0.01449021,
-0.032497972,
-0.011497667,
0.0006656933,
0.0031894215,
0.028297912,
-0.019412158,
0.0068382244,
0.015080844,
0.007087603,
0.004820226,
0.0070547904,
-0.001504475,
0.04123935,
-0.005952274,
0.011313914,
-0.0007190144,
0.004872727,
0.023205338,
-0.0031795776,
0.0032255156,
-0.012632997,
0.004472409,
-0.008308246,
0.037616797,
0.01916278,
-0.009975146,
0.01855902,
-0.027116645,
-0.0021853442,
-0.020120919,
-0.024622858,
-0.011274539,
-0.026539136,
0.002490505,
0.011392666,
0.005348515,
0.015277722,
0.00670041,
0.007678237,
0.023822222,
0.039454326,
-0.026184756,
0.0027530089,
0.009167946,
0.016288362,
-0.011727358,
-0.0011689623,
-0.03430925,
-0.035306763,
0.019727163,
-0.0152383465,
-0.031972967,
-0.023546593,
0.012718311,
0.0053616404,
-0.000659951,
-0.031159203,
0.009312323,
0.005191013,
0.0120358,
0.011346728,
-0.0059227427,
0.025147866,
-0.00821637,
-0.005794772,
-0.0017374472,
0.0034945821,
-0.0028662137,
-0.00394412,
0.0061196205,
0.020357171,
-0.026342258,
-0.007966991,
-0.009496076,
0.008675751,
-0.026289757,
0.008111368,
-0.0012509947,
-0.014214582,
-0.0035667706,
-0.013144879,
0.00960764,
-0.013768326,
-0.010014521,
0.006224622,
0.0065396265,
0.017404003,
-0.024412856,
-0.006267279,
-0.0015618977,
-0.031054202,
-0.0060408693,
-0.01340082,
-0.04331313,
0.030739198,
0.023126587,
0.02344159,
-0.0032878604,
0.023861598,
-0.04688318,
0.0007428038,
0.01082172,
0.0052730455,
0.01792901,
0.055073302,
-0.013322069,
0.007527297,
-0.00295809,
0.010802032,
-0.028455414,
-0.008406685,
0.009430449,
-0.023612218,
0.0039769327,
-0.008872629,
-0.004288656,
-0.021800943,
0.0051582,
-0.002457692,
-0.0038522435,
0.01823089,
-0.011668295,
-0.0065068137,
0.012587058,
0.01094641,
-0.019149654,
-0.000627138,
-0.005994931,
-0.020790303,
-0.008702002,
-0.0018752617,
-0.0066708783,
0.013138317,
-0.004459284,
0.0206853,
0.0076716742,
-0.009482951,
-0.016314613,
-0.027116645,
-0.007638861,
0.0037373982,
0.013847076,
0.01446396,
-0.016498365,
0.023297215,
-0.0073632323,
0.013952078,
-0.01858527,
0.0012075176,
-0.002303471,
0.0075666727,
-0.0061655585,
-0.011458292,
-0.016616492,
0.0045478786,
0.022824707,
-0.030424193,
-0.006949789,
-0.016235862,
-0.0014175207,
-0.030135438,
0.009036694,
0.008623251,
-0.013479571,
0.003714429,
-0.009115445,
0.0010918519,
-0.01918903,
0.0033239545,
0.0045478786,
-0.022247199,
-0.013033315,
-0.000988491,
0.013571448,
0.01967466,
-0.00925326,
-0.00082688703,
-0.034020495,
-0.00670041,
0.1790276,
-0.010933284,
0.012508307,
-0.0083804345,
-0.012134239,
0.0005483869,
0.011556731,
-0.0018818242,
0.0072254175,
0.0052402327,
0.027090395,
-0.017732132,
0.022391576,
0.0044133454,
0.02189282,
-0.01067078,
0.0048530395,
-0.02065905,
-0.008669188,
-0.031789213,
0.010907033,
-0.009391074,
0.026224133,
-0.012029238,
0.03373174,
0.016734619,
-0.016721493,
0.017994637,
0.030712947,
0.01473959,
-0.0257385,
0.026250383,
-0.002821916,
-0.0033403612,
-0.0050302297,
0.0055683623,
-0.022588454,
-0.015041469,
-0.0026037097,
0.008997318,
0.010395152,
-0.0007428038,
-0.013420508,
0.020409672,
0.009181071,
0.01861152,
0.00156764,
-0.006227903,
-0.0061918087,
0.009909519,
-0.032576725,
-0.022824707,
0.007579798,
0.01334832,
0.025252867,
0.0012657606,
0.027641652,
0.026709763,
-0.004249281,
0.004948197,
-0.011136725,
-0.000014458218,
-0.03239297,
0.03635678,
0.0042263116,
0.022142198,
-0.015015218,
-0.026814766,
-0.015684603,
0.003182859,
0.008098243,
0.0029269175,
-0.017128374,
-0.0064608753,
-0.010926722,
-0.0007132721,
0.031474207,
0.030660447,
0.018309642,
0.0031336395,
-0.005276327,
0.02303471,
-0.0080654295,
0.013079253,
0.0013264646,
-0.039953083,
0.020567175,
0.0043838136,
-0.012902062,
-0.0018801836,
-0.0097520165,
-0.0039178696,
-0.00056110194,
0.004209905,
-0.006283685,
0.0066249403,
0.018769024,
0.009023569,
-0.026644139,
-0.0343355,
-0.043496884,
0.07791113,
0.02748415,
0.006746348,
-0.0012165412,
0.013118628,
-0.0012157208,
-0.008281996,
-0.009397637,
-0.015645228,
0.021275934,
-0.029925436,
0.0074879215,
-0.0027087112,
-0.012921751,
0.028534165,
-0.0041574044,
0.008997318,
0.0241241,
-0.004889134,
0.00788824,
-0.03640928,
0.0076191733,
0.012665809,
-0.004459284,
-0.012639559,
-0.019307155,
0.02748415,
0.011287664,
-0.034177996,
-0.009778268,
-0.025843501,
0.00872169,
0.022010945,
-0.008826691,
0.0025397246,
0.009030132,
0.0029843403,
-0.037380543,
0.041554354,
-0.024714734,
-0.020829678,
0.0014815059,
0.001934325,
0.010513278,
-0.0038752127,
-0.0006140128,
0.02516099,
-0.017535254,
-0.03633053,
-0.02958418,
-0.03551677,
0.0017981512,
-0.017456504,
0.025239743,
-0.01752213,
-0.023599094,
-0.023533467,
-0.015618977,
0.0029269175,
-0.007986679,
0.02884917,
0.011274539,
-0.009089195,
-0.006309936,
-0.0072647934,
-0.16327737,
0.00063862256,
0.0094567,
-0.014910217,
0.044153143,
-0.0065527516,
-0.0037734925,
0.00872169,
-0.017771509,
0.017955262,
0.02816666,
0.003461769,
-0.027720403,
-0.011267977,
-0.0060014934,
0.010611717,
-0.017062748,
0.035464264,
0.012291742,
0.00034022957,
0.020619676,
-0.033154234,
0.012298304,
-0.00788824,
-0.002144328,
0.012613309,
0.01013921,
0.030896699,
0.004108185,
-0.016708368,
-0.0030450444,
-0.03310173,
0.028009158,
0.0006136027,
0.030712947,
-0.009975146,
0.0060769636,
-0.025200367,
-0.015435224,
0.017771509,
0.024163477,
0.012304867,
0.026578512,
0.0069038505,
-0.016235862,
0.024517857,
0.0055946126,
-0.0048825713,
0.03021419,
-0.0026299602,
0.033442985,
-0.0018030731,
0.005893211,
0.021197183,
0.019490909,
0.012934876,
0.024412856,
0.0061983713,
0.0024790205,
0.004531472,
-0.0019507315,
-0.009476388,
0.01848027,
0.00591618,
-0.0048300703,
-0.03294423,
0.02442598,
0.0019819038,
-0.017115248,
0.007894803,
-0.015986484,
-0.013938953,
0.017102124,
-0.020409672,
0.009876707,
0.010329525,
-0.004078653,
0.0056471135,
0.0019983104,
-0.012022675,
-0.002536443,
0.0070154145,
-0.01683962,
-0.009916082,
-0.015382724,
-0.0137552,
0.010093272,
0.008833254,
0.021184059,
-0.010775782,
-0.011537043,
-0.028639168,
-0.0030483257,
-0.013768326,
0.015527101,
0.02191907,
0.013413945,
-0.0035503642,
-0.003148405,
0.010145772,
0.01069703,
-0.0064871255,
-0.032419223,
0.0002584022,
0.007350107,
-0.0016193205,
-0.0032534068,
0.0030877013,
0.015605852,
0.007947303,
-0.0077635506,
0.023848472,
0.011189225,
0.025961628,
-0.019556535,
-0.0067266603,
0.018939652,
-0.014529587,
-0.00018467553,
-0.021197183,
0.07082353,
-0.014175206,
-0.0029384021,
-0.0016365473,
0.00788824,
-0.029321676,
-0.13797201,
-0.03940182,
0.0070285397,
0.0017981512,
-0.019438408,
0.0047119437,
-0.012298304,
0.025489122,
-0.020370297,
0.029794184,
-0.01954341,
-0.0040491214,
-0.0023773003,
-0.027930407,
0.008183557,
-0.00070301804,
0.008918568,
0.008314809,
-0.03310173,
0.030660447,
0.0071663545,
-0.0021131558,
0.00020446586,
-0.020895304,
0.0020737802,
-0.0062607164,
-0.022444077,
0.019832164,
0.010263899,
0.0015766636,
0.012659247,
-0.020081542,
0.010152335,
0.0017128375,
0.011865173,
0.0103164,
-0.0022591734,
-0.028324163,
0.032629225,
-0.009200759,
-0.010460777,
0.009325448,
0.012508307,
0.019937165,
0.0013256443,
-0.0015963514,
-0.035884272,
-0.006897288,
0.030292941,
-0.012619872,
-0.007816051,
-0.0274054,
-0.030660447,
-0.0031877807,
0.006657753,
0.0274054,
-0.015317098,
0.029164175,
-0.020291544,
0.012921751,
0.022850957,
-0.0049219467,
-0.021197183,
0.014831466,
0.029820435,
-0.023822222,
-0.03383674,
-0.009167946,
0.010795469,
-0.0378268,
-0.0019146373,
-0.016957747,
0.0014946312,
-0.014529587,
-0.0075010466,
0.029269176,
0.0009031772,
-0.010257337,
0.00983733,
-0.023900973,
-0.011287664,
-0.015080844,
0.028035408,
-0.008196682,
0.034151748,
0.019097153,
0.015382724,
0.004433033,
0.0036783349,
-0.0007760269,
-0.00033079582,
0.045150656,
0.013571448,
-0.011484542,
-0.0071138535,
0.0102770245,
-0.013033315,
-0.026631013,
0.024767235,
0.028744169,
-0.012488619,
-0.021079056,
-0.040871844,
0.007107291,
0.00422303,
-0.011025161,
0.010480465,
-0.006962914,
-0.0006816896,
-0.010034208,
0.010500153,
0.024819735,
-0.0058144596,
0.014687088,
0.00055166817,
0.012764248,
-0.03388924,
-0.046305675,
0.014988968,
-0.006129464,
0.004140998,
0.039008066,
-0.008787315,
-0.015028344,
0.015999608,
0.043181878,
-0.010959535,
-0.007802926,
-0.020186543,
0.022010945,
-0.020409672,
0.004341157,
-0.0018063544,
-0.038063053,
-0.0027612122,
0.014057079,
-0.007061353,
-0.017758384,
0.0036192713,
0.03727554,
-0.0024183164,
0.044441897,
-0.019819038,
-0.038036805,
0.014621463,
0.0124951815,
-0.034755506,
-0.009496076,
-0.051214494,
-0.0030811387,
-0.007304169,
-0.017561506,
0.0482482,
-0.0073632323,
-0.00040359964,
-0.05958837,
-0.014267082,
0.039585575,
0.011996425,
-0.0037078664,
-0.025620373,
-0.020987181,
0.026631013,
0.011169538,
-0.0012222835,
0.010401714,
0.0063427486,
-0.013965203,
-0.026329134,
0.015080844,
-0.009338574,
-0.013807701,
-0.011313914,
0.01099891,
0.016668992,
0.0064838445,
0.014306459,
0.01921528,
0.0023707377,
-0.004275531,
0.0047152247,
0.007868552,
0.008629813,
0.008150743,
-0.00584071,
0.0018326048,
0.041501854,
0.0072647934,
-0.011747046,
0.022667205,
-0.014280207,
-0.012239241,
0.014805215,
0.008413248,
0.009220446,
0.025594123,
0.019530285,
-0.0037636484,
0.012757686,
0.01992404,
0.024544107,
0.030791698,
-0.016905246,
0.010867658,
-0.0030614508,
-0.0343355,
-0.00044051424,
0.0055388305,
-0.053970784,
-0.01678712,
-0.028192911,
0.02134156,
-0.005686489,
0.0030942638,
-0.02131531,
-0.006145871,
-0.023743471,
0.00841981,
-0.00033735842,
0.0005775084,
-0.017640257,
0.024163477,
-0.0006677441,
0.009312323,
-0.009555139,
-0.0117601715,
-0.009181071,
0.009699516,
0.029059174,
-0.03378424,
0.014988968,
0.016301487,
-0.001633266,
-0.012777373,
-0.0110185975,
0.0014478726,
-0.007756988,
-0.033521738,
0.01686587,
0.021512188,
0.014385209,
0.081533685,
-0.0032780166,
-0.013420508,
0.00419678,
-0.0074354205,
-0.010782344,
-0.0002670156,
0.009955457,
-0.009561702,
0.010992347,
0.024176601,
-0.0010943128,
0.03281298,
-0.02333659,
-0.04467815,
0.019097153,
-0.021814067,
0.020777177,
-0.002976137,
-0.0014708417,
0.03583177,
-0.017758384,
0.01638024,
-0.0031795776,
0.00016621823,
-0.0051942943,
0.029137924,
-0.027326647,
-0.008734815,
-0.028717918,
0.027720403,
0.0009327089,
-0.058695853,
-0.016721493,
0.015330223,
-0.031395458,
0.007441983,
-0.017797759,
0.0091220075,
0.0154483495,
-0.010966097,
0.036698036,
-0.01147798,
-0.0085904375,
-0.016419614,
-0.010651093,
-0.029321676,
-0.013571448,
-0.011661733
] |
The actin cortex both facilitates and hinders the exocytosis of secretory granules. How cells consolidate these two opposing roles was not well understood. Here we show that antigen activation of mast cells induces oscillations in Ca(2+) and PtdIns(4,5)P(2) lipid levels that in turn drive cyclic recruitment of N-WASP and cortical actin level oscillations. Experimental and computational analysis argues that vesicle fusion correlates with the observed actin and Ca(2+) level oscillations. A vesicle secretion cycle starts with the capture of vesicles by actin when cortical F-actin levels | [
-0.014090838,
-0.0017697823,
0.013416635,
-0.021668877,
-0.010470369,
0.022194756,
-0.02327348,
-0.0013028969,
0.00242713,
-0.02218127,
0.030743647,
0.015830282,
0.007207228,
0.016666293,
0.005592512,
0.0032799966,
0.03168753,
0.017529272,
-0.022370048,
-0.005774547,
-0.037890196,
0.009061285,
-0.012594108,
-0.025687126,
0.018149538,
-0.009047802,
0.00033267692,
-0.027520958,
-0.0011739556,
-0.016706744,
0.0024911792,
0.015897702,
0.004318269,
0.010746792,
-0.009148932,
-0.008906219,
0.0335753,
-0.0017647258,
0.009364677,
-0.00077491184,
0.014360519,
0.00021405939,
-0.0063712164,
0.0018473156,
0.0007159191,
0.0016787649,
0.015452728,
0.02361058,
-0.011629998,
0.009479291,
0.015479696,
0.039292537,
-0.010409691,
0.014171743,
-0.014239163,
-0.029017687,
0.008650022,
0.011225476,
0.011468189,
-0.022585792,
-0.007962335,
0.015075174,
-0.00046435717,
0.020684542,
0.0031131313,
0.023907231,
0.0029799764,
0.014090838,
-0.0035159674,
-0.0074364566,
0.043769244,
0.017569724,
-0.017030362,
-0.02014518,
0.012661528,
-0.015466211,
-0.03465402,
-0.023947682,
-0.009654583,
0.018149538,
0.009432097,
-0.010598468,
-0.021102548,
0.054313775,
0.010092815,
0.024675822,
-0.002290604,
0.013268311,
-0.0039744256,
-0.0072207116,
0.012701981,
0.020482281,
0.024149943,
0.0024187025,
0.0050329235,
0.008596085,
0.006522912,
0.017731532,
-0.020940738,
-0.0047396454,
0.008737668,
0.0062195207,
-0.029179497,
-0.03470796,
-0.030123381,
-0.008016271,
0.009883813,
-0.0110367,
0.030015508,
0.0013130099,
-0.014400971,
0.0057678046,
-0.0010702969,
-0.05026856,
0.013821157,
0.0037418255,
0.0064790887,
0.0059666946,
-0.015398791,
-0.016315708,
0.011994068,
0.042663552,
0.019875498,
0.00033984034,
0.025012923,
-0.0019400185,
0.0024928648,
-0.0076926537,
-0.02001034,
-0.011077152,
-0.0025484865,
0.014684137,
-0.0066442685,
0.0032429153,
-0.006802706,
0.017650628,
-0.015695442,
0.004045217,
-0.0013686316,
-0.028478326,
-0.008872509,
0.03624514,
-0.0071870014,
0.0055992543,
-0.011434479,
0.024594918,
0.02699508,
0.0022838619,
0.0035361936,
0.023138639,
0.00051112997,
-0.017812438,
-0.0042946716,
-0.008501697,
0.016099961,
0.020900287,
-0.006762254,
0.025970291,
-0.023462256,
-0.027440052,
0.00254343,
0.004611547,
0.034465246,
-0.007847721,
0.041045465,
0.02304425,
0.0142661305,
-0.0142661305,
0.0071802596,
0.0021793605,
0.0002768445,
-0.004614918,
-0.015681956,
0.029287368,
-0.016598873,
0.029610986,
0.02011821,
0.0047935816,
-0.030312156,
-0.016369643,
-0.019969886,
-0.003859811,
0.009196126,
0.009870329,
-0.01456278,
-0.0052082166,
0.03395285,
-0.011427737,
0.0012472752,
-0.014899882,
-0.0133896675,
0.0054947524,
-0.017434884,
-0.0021405937,
-0.63601595,
-0.023286965,
0.02014518,
-0.013025598,
-0.019228263,
0.030662742,
-0.0054509295,
0.004584579,
-0.026064679,
-0.014711104,
-0.020617122,
0.020468796,
-0.0016298852,
-0.02197901,
0.00074035896,
-0.034627054,
-0.014899882,
-0.017691081,
0.03168753,
-0.0066880914,
-0.018082118,
0.0036002428,
-0.007335326,
0.030285189,
0.0025653415,
0.009553453,
0.030258222,
-0.0025585995,
-0.009877071,
0.021008158,
-0.01818999,
0.005771176,
-0.02197901,
0.010193946,
0.051940583,
0.015884217,
-0.011906421,
0.041234244,
0.006030744,
0.048569568,
-0.016517969,
-0.009094995,
0.010598468,
0.0022181273,
-0.020482281,
0.00041294922,
-0.003954199,
0.00007316154,
-0.00020963492,
-0.009506259,
0.02383981,
-0.009539969,
-0.015331371,
0.016477516,
0.0052857497,
-0.010504079,
0.028343486,
-0.017933793,
-0.011333349,
0.02812774,
0.004082298,
0.03317078,
-0.023974651,
-0.03381801,
-0.015816797,
0.022167787,
-0.02513428,
0.011576062,
0.013288537,
0.015722409,
0.00050944445,
0.019120391,
-0.009068027,
0.028208645,
0.004871115,
0.019268716,
-0.0070521613,
-0.01063892,
-0.007483651,
0.023678001,
0.006876868,
0.013767221,
-0.029422209,
0.0055284626,
0.0063678455,
0.003876666,
-0.023259996,
0.02377239,
0.010234398,
-0.004608176,
0.0025451155,
0.012041261,
-0.0123176845,
-0.042933233,
-0.030258222,
0.020859834,
0.017529272,
0.006836416,
0.0021473358,
-0.016679777,
0.0075308452,
0.0035429357,
-0.013093018,
-0.027642313,
0.020576669,
0.005329573,
-0.04937861,
-0.011987326,
0.048326854,
-0.039157696,
0.011110862,
0.009472549,
-0.0025602852,
-0.028235612,
-0.0020006967,
-0.021062095,
0.013079534,
0.028882846,
-0.019160843,
-0.011468189,
0.007942108,
-0.027574893,
0.019120391,
0.0032210038,
0.005643077,
0.0098501025,
0.0040182485,
-0.0150616905,
-0.017812438,
0.0009691665,
-0.014670652,
-0.0014689193,
0.019187812,
-0.012041261,
0.039912805,
0.034195565,
0.02340832,
0.024689306,
0.008002787,
-0.044901904,
-0.029610986,
-0.002224869,
0.0018523721,
-0.008339888,
-0.0068701264,
-0.010315303,
-0.04325685,
0.0046654833,
0.011596288,
0.008070207,
0.010908601,
-0.012088456,
-0.0051542805,
-0.0011326607,
0.025053374,
-0.0020984563,
-0.013686316,
-0.00040157203,
-0.00877812,
-0.03098636,
0.0035024835,
0.0002896965,
-0.030231252,
0.024797179,
-0.016571904,
-0.005103715,
0.0072004856,
-0.014953817,
-0.00508686,
-0.02377239,
0.011616514,
-0.012978404,
-0.0082185315,
0.035463065,
0.0018473156,
0.0069240625,
-0.0045373845,
-0.015884217,
-0.023920715,
0.0007374093,
-0.009162416,
-0.027318697,
0.012695238,
-0.00009101738,
0.034869768,
0.017178686,
0.026711915,
0.0004416028,
-0.017974246,
0.036487855,
-0.013746995,
-0.0042508487,
-0.013618896,
-0.0061183902,
-0.010375981,
-0.039022855,
0.017798953,
0.013376183,
0.018742837,
0.020333955,
0.0052318135,
0.0032125763,
0.0050329235,
-0.0050160685,
0.001223678,
-0.004611547,
-0.015331371,
-0.023071218,
0.04255568,
0.014117806,
0.020967707,
0.008407309,
0.0063880715,
0.0046621123,
0.013969482,
-0.0028485067,
0.0032479719,
-0.01063892,
-0.00004795794,
-0.013194148,
0.011582804,
-0.015695442,
0.019767625,
-0.004628402,
-0.025511833,
0.014117806,
0.019511428,
0.02327348,
-0.004847518,
-0.011306381,
-0.009681552,
0.0040519587,
0.011380543,
0.023219544,
0.013416635,
0.002888959,
-0.000014866698,
0.007227454,
0.024109492,
-0.0061824396,
0.0073757786,
0.010537789,
0.005804886,
-0.002071488,
-0.013639122,
-0.023246512,
0.029880667,
0.005363283,
0.0029344675,
0.0022231836,
0.00724768,
0.011603029,
-0.022788053,
0.0034064096,
-0.0059329844,
-0.027858058,
0.01578983,
0.0032378589,
0.03840259,
0.035490036,
0.030123381,
-0.0028282807,
0.013436861,
-0.01864845,
-0.021857655,
0.0057071266,
0.008191564,
-0.005629593,
-0.009796167,
-0.02134526,
-0.01662584,
0.007261164,
0.017434884,
-0.024217363,
0.011144572,
0.0035665326,
0.018324832,
-0.0089331865,
0.0017478707,
0.015803313,
-0.010949053,
-0.04368834,
-0.010308561,
0.006512799,
-0.005514979,
-0.008447761,
-0.017839406,
-0.0011090636,
0.002270378,
0.0056565613,
-0.007517361,
0.017812438,
-0.01316718,
-0.02084635,
-0.018095603,
-0.023030767,
0.018540576,
0.00047236332,
0.004668854,
-0.006310538,
0.004116008,
0.008373599,
-0.00728139,
-0.0018725982,
0.016895521,
0.009459065,
-0.0015489808,
-0.002765917,
0.0011806976,
-0.022302628,
0.0049385354,
0.009405129,
-0.001931591,
-0.0049992134,
-0.0023310562,
-0.011441221,
0.013268311,
-0.017664112,
0.04436254,
0.021075578,
-0.013153696,
-0.0010180462,
0.005595883,
-0.015142594,
0.0058790483,
0.016491,
0.0036002428,
0.00974223,
-0.011906421,
-0.010544531,
-0.019956402,
-0.010531047,
0.008494955,
-0.019996854,
0.00030339125,
-0.019942919,
0.01353125,
-0.004837405,
0.008265726,
0.01692249,
-0.012000809,
-0.015236983,
-0.0069375467,
0.0049216803,
0.012587366,
0.0038463268,
0.031175137,
0.041665733,
0.019120391,
0.0059700655,
-0.009101737,
0.023664517,
-0.014616717,
-0.012681754,
0.006802706,
0.016935974,
0.0054003643,
0.007706138,
-0.014360519,
-0.05711846,
-0.019956402,
0.039993707,
-0.014239163,
0.000779547,
-0.006785851,
0.013982966,
0.004911567,
-0.015425759,
-0.0057206107,
-0.019120391,
0.022491405,
0.010787245,
-0.0047126776,
0.008629795,
0.028586198,
-0.028073804,
-0.008258984,
-0.02642875,
-0.0018692272,
-0.0054307035,
-0.00075047195,
-0.00053304154,
0.0024810662,
-0.013848125,
-0.007018451,
0.005147538,
-0.023354385,
-0.022100367,
-0.01642358,
-0.010059105,
-0.02563319,
-0.02642875,
-0.033035938,
0.0022821764,
-0.00937816,
-0.042339936,
-0.038780145,
0.0034822572,
0.030581838,
0.019309167,
0.017637145,
-0.0008899477,
-0.010935569,
0.02812774,
-0.02098119,
-0.00010724038,
-0.02842439,
-0.04341866,
0.01499427,
-0.0044598514,
0.026806302,
-0.0013180664,
-0.009492775,
-0.02191159,
0.012870531,
-0.012149134,
0.02227566,
0.004416028,
-0.008960155,
0.003842956,
0.023961166,
0.017178686,
-0.0016551678,
0.0029041285,
-0.0067588827,
-0.038456526,
-0.0024760098,
-0.006506057,
0.0064521204,
-0.0022568938,
0.0028923298,
0.008602828,
-0.010726566,
-0.010996248,
-0.009270288,
-0.012310943,
-0.017232623,
-0.016882038,
0.002802998,
0.034492213,
0.007294874,
0.016935974,
-0.01167045,
-0.018702386,
-0.009964717,
-0.0061655845,
0.01864845,
-0.01934962,
-0.024662338,
0.019012518,
-0.006293683,
0.010059105,
-0.014508843,
0.010726566,
-0.0068128193,
0.021493584,
-0.0011764838,
-0.02143965,
-0.02783109,
0.011326606,
0.0020293503,
0.0024996067,
-0.013423378,
-0.013382925,
-0.015911186,
0.0011250759,
-0.011542352,
-0.019511428,
0.028774975,
-0.03427647,
-0.007975819,
0.0058554513,
-0.0011385599,
0.00827921,
0.0033676429,
-0.009722004,
-0.033791043,
-0.02350271,
-0.025754547,
-0.04695148,
-0.0035631617,
-0.018068634,
0.030770615,
0.021304809,
0.04695148,
0.012324427,
0.019026002,
0.010767018,
-0.012122166,
-0.011191766,
-0.0013281795,
0.02150707,
-0.017448368,
0.036056366,
0.016531453,
0.0028046835,
0.026873723,
-0.009695036,
0.018796774,
-0.0048643732,
-0.0035463066,
-0.026455717,
-0.0001019205,
-0.031390883,
-0.016113447,
0.029314337,
-0.009627616,
-0.028073804,
-0.016909005,
-0.013079534,
0.026873723,
0.008946671,
0.00096242444,
-0.024945503,
0.0019990113,
-0.022248691,
0.026118616,
-0.024918534,
-0.0044935616,
-0.019781109,
-0.02556577,
0.005036295,
0.0019872128,
0.010881633,
-0.011164798,
-0.0014006563,
0.028208645,
0.012115424,
-0.02034744,
0.013328989,
-0.013625639,
-0.004378947,
-0.0110434415,
-0.02340832,
-0.020698026,
-0.017664112,
-0.020387892,
-0.032199923,
-0.008764636,
0.022990314,
-0.010032137,
0.022653213,
-0.00085623754,
-0.00860957,
0.037917163,
0.006586961,
0.031013329,
-0.015398791,
0.010901859,
0.011387285,
0.014549296,
0.0027389487,
-0.004318269,
-0.014616717,
0.0052452977,
0.05010675,
0.018392252,
-0.00927703,
-0.01728656,
-0.011845743,
0.017623661,
-0.0039575705,
-0.027938964,
0.015317887,
0.011259186,
0.020940738,
-0.020724993,
-0.008960155,
-0.024122976,
0.009627616,
-0.01798773,
0.011764838,
0.0034485473,
-0.0047565005,
-0.03584062,
0.011576062,
-0.006543138,
0.03654179,
0.016868554,
-0.0042811874,
0.00024355575,
-0.0011646854,
0.0066139293,
0.013679574,
-0.008353372,
-0.005164393,
-0.013982966,
0.010086074,
0.01578983,
0.011569319,
0.008737668,
-0.008879251,
-0.001627357,
0.041099403,
0.009081512,
0.001562465,
0.025053374,
-0.0061622136,
0.007901656,
-0.016099961,
0.0034552892,
0.0075847814,
-0.02563319,
0.00920961,
0.028343486,
-0.00821179,
-0.006789222,
-0.010281593,
-0.010456885,
-0.012937951,
-0.017475337,
0.0135514755,
-0.008144369,
-0.043445628,
-0.01841922,
0.012290717,
0.0011225477,
0.011299639,
-0.008076949,
-0.00093545637,
-0.010598468,
0.018257411,
-0.024635369,
0.01655842,
0.01605951,
0.0014343665,
-0.03996674,
-0.004800324,
0.0066240425,
-0.0186889,
0.019605817,
-0.035948493,
-0.03414163,
0.002540059,
-0.0028603054,
0.01672023,
0.025983775,
0.0056194803,
0.0034266356,
0.0040721847,
0.018958582,
0.011926647,
0.001644212,
-0.005845338,
-0.009135447,
-0.018230444,
0.018109087,
-0.012337911,
-0.013308763,
0.020306988,
0.0048980834,
0.012290717,
-0.0060981642,
-0.009418613,
-0.007935367,
-0.0098096505,
-0.017448368,
0.0016998338,
-0.011744613,
-0.020172147,
-0.01735398,
0.0010863092,
-0.0017546128,
-0.0000660508,
-0.005295863,
-0.019026002,
0.021668877,
-0.0007892386,
-0.029637953,
0.017731532,
-0.014333551,
-0.024554465,
-0.025417445,
0.0047565005,
-0.023354385,
0.041908443,
0.0029176124,
-0.012310943,
-0.017583208,
0.009391645,
-0.01669326,
-0.0022501517,
-0.0076656854,
0.00080862193,
0.014050386,
0.013773963,
-0.015722409,
0.01074005,
0.0026024228,
-0.0007820752,
0.0057678046,
0.009216352,
0.0028704184,
-0.029098593,
0.028613165,
-0.001104007,
-0.013902062,
0.007867946,
0.032307796,
0.003842956,
0.0122367805,
0.021102548,
0.01220307,
0.0037991328,
-0.000015182731,
0.0054913815,
-0.016598873,
0.016046027,
0.02304425,
-0.046627864,
0.022801537,
0.0082455,
-0.001329865,
-0.018729353,
-0.0057071266,
-0.009762457,
-0.016356159,
0.0059666946,
0.009088254,
-0.020104727,
0.0011950245,
-0.011501899,
0.021668877,
0.04023642,
-0.0054543004,
0.012378363,
0.039292537,
-0.018742837,
-0.029449178,
0.0066543813,
-0.019255232,
-0.0055284626,
0.004628402,
-0.007928625,
-0.00415646,
0.016747197,
0.02626694,
-0.036514822,
-0.0089331865,
-0.019969886,
0.028963752,
-0.032334764,
0.025323056,
0.01721914,
-0.012378363,
0.00468908,
-0.018877678,
-0.021372229,
-0.02077893,
0.00269344,
-0.010389465,
-0.00462166,
-0.0030103154,
0.0063914424,
-0.01748882,
0.004763243,
-0.0214801,
-0.012324427,
0.003108075,
0.0019299055,
0.18877678,
-0.026644494,
-0.020037306,
0.028046835,
-0.017043846,
-0.019632785,
-0.004631773,
-0.00581837,
0.004604805,
-0.014832461,
0.019794594,
0.017798953,
0.0026209634,
-0.0059430976,
0.013039081,
-0.0021287953,
-0.0010079332,
0.0059329844,
-0.0044733356,
0.0030541385,
0.026186036,
-0.018378768,
0.010416433,
0.0019619302,
0.05083489,
-0.020900287,
-0.007969077,
-0.0016585388,
-0.012884015,
0.015897702,
-0.028586198,
0.02034744,
-0.0011174912,
0.014508843,
-0.013173922,
0.004648628,
-0.010389465,
0.00831292,
0.017839406,
0.006768996,
0.023691487,
-0.014023418,
-0.0069375467,
0.004672225,
-0.013079534,
0.0037822777,
0.018324832,
-0.020495765,
-0.005882419,
-0.0023698227,
-0.04999888,
0.01526395,
0.00088067737,
0.01492685,
-0.005167764,
0.008387082,
0.011265929,
0.024419624,
-0.004631773,
0.034896735,
-0.04082972,
0.011299639,
-0.029637953,
0.027332181,
-0.014549296,
0.0054408163,
-0.009647842,
-0.0097287465,
0.024878083,
-0.021223903,
0.025875902,
0.0069442885,
-0.0029681777,
-0.0063543613,
-0.004611547,
0.011252444,
0.007928625,
0.0037215992,
0.012344653,
0.026374813,
0.03557094,
0.008690474,
-0.027453538,
-0.019727174,
-0.004358721,
-0.034815833,
0.0073960046,
0.0044868193,
-0.012115424,
-0.007004967,
-0.01213565,
-0.03686541,
-0.0077870423,
-0.0060206307,
0.008926445,
-0.011555836,
0.008420792,
-0.0007146549,
-0.016706744,
-0.020671057,
-0.030473966,
0.06035463,
0.02420388,
0.017893342,
-0.004341866,
-0.010504079,
-0.0047227903,
0.026010742,
-0.0004913253,
-0.019079939,
0.030339126,
-0.02470279,
-0.006030744,
-0.02170933,
-0.019255232,
0.007227454,
-0.004874486,
0.007894915,
0.03958919,
-0.022450952,
-0.015021238,
-0.02164191,
0.0008941614,
0.014212195,
0.010423175,
0.0057340944,
-0.011650224,
0.019605817,
-0.011306381,
-0.05350473,
0.02912556,
0.007969077,
0.0018102345,
0.008400567,
-0.014913365,
-0.012270491,
-0.0054543004,
-0.02656359,
0.0024591547,
-0.003630582,
-0.01818999,
-0.0035125965,
0.01662584,
0.03141785,
-0.0004386532,
0.000002947991,
0.0042710747,
0.027075984,
-0.015075174,
-0.036622696,
-0.013328989,
-0.013261569,
-0.0012691867,
-0.012142392,
0.025781514,
-0.02912556,
-0.021075578,
-0.031606626,
-0.007288132,
-0.003650808,
-0.019969886,
-0.0058925324,
0.024352204,
-0.010119784,
-0.0011983954,
-0.0311212,
-0.16946761,
0.0013028969,
0.018527092,
-0.013686316,
0.015439244,
0.020967707,
-0.0069240625,
0.0074769086,
-0.0044025443,
-0.0014781896,
0.023651034,
0.017232623,
-0.029395241,
-0.007355552,
0.012958177,
-0.0082185315,
-0.0016602244,
0.009094995,
0.020158663,
0.0071060974,
0.03686541,
-0.03945435,
0.02839742,
-0.024675822,
0.011549094,
0.015601052,
0.0057509495,
-0.005845338,
0.01177158,
-0.03341349,
-0.0034232647,
0.0022434096,
0.023125155,
0.0074229725,
0.017097782,
0.014023418,
-0.0014849316,
-0.008764636,
-0.0047194194,
0.018675417,
0.029961571,
0.02712992,
0.0029850327,
0.0039238604,
0.011616514,
0.02783109,
-0.015048206,
-0.0033861834,
0.016032541,
-0.030608807,
0.0252017,
-0.002181046,
0.009148932,
0.033467427,
-0.004345237,
0.021736298,
0.026725398,
0.016517969,
0.013086276,
0.006303796,
0.02576803,
-0.004847518,
0.033898916,
-0.002519833,
-0.006765625,
-0.008683732,
-0.0035665326,
0.027156888,
-0.021169968,
0.012580624,
0.0039777965,
0.0033288763,
0.0023192575,
-0.02191159,
0.013686316,
0.015722409,
-0.0077331057,
-0.002529946,
-0.0038463268,
0.028370453,
-0.012250264,
0.010423175,
-0.037350833,
-0.02699508,
-0.020698026,
-0.0037789065,
-0.004908196,
0.025714094,
0.00588579,
0.008393825,
-0.0011739556,
-0.022289144,
0.0076791695,
0.00052587816,
0.03225386,
0.01898555,
-0.015897702,
0.01406387,
0.0059565813,
0.0026917546,
0.020064274,
0.0110838935,
-0.014050386,
0.01685507,
0.0048845992,
0.00365755,
-0.0015093714,
-0.007544329,
0.042663552,
-0.037485674,
0.0040283618,
0.010288334,
0.012000809,
0.020158663,
-0.007497135,
0.022612762,
0.01592467,
0.0044767065,
0.00083390455,
0.00035922366,
0.057603884,
-0.0009868643,
-0.01585725,
-0.0023782502,
-0.016369643,
-0.032496575,
-0.15954335,
-0.043310788,
0.008892735,
0.05196755,
-0.020549702,
0.013699801,
-0.0009834933,
0.022815023,
-0.011744613,
0.035517003,
-0.016342675,
-0.009984943,
-0.007915141,
0.00078881724,
-0.0044362545,
0.0130727915,
0.021655394,
-0.0042474773,
-0.025457896,
0.024743242,
-0.008521923,
-0.0008566589,
0.002922669,
0.0047699846,
-0.017111266,
0.0034654022,
-0.011474932,
0.046034567,
0.0009691665,
0.01885071,
-0.00007542643,
-0.0027945705,
0.027669283,
-0.0071060974,
-0.017515788,
-0.017178686,
-0.007544329,
-0.02204643,
0.016383128,
-0.001025631,
-0.004449738,
0.021183452,
0.015897702,
-0.007011709,
-0.0062431176,
-0.008838799,
-0.005804886,
-0.014009934,
0.011373801,
-0.0055453177,
-0.022194756,
-0.0096411,
-0.024473561,
-0.016086478,
0.012648044,
0.0049722455,
-0.008407309,
0.023381352,
-0.005865564,
-0.009175899,
0.0030743647,
0.0054913815,
-0.01000517,
0.0080567235,
0.04309504,
-0.0015009439,
-0.01898555,
-0.024419624,
0.017380947,
-0.01063892,
0.0029513226,
0.010881633,
-0.019174326,
0.018581029,
-0.011009731,
-0.014077354,
-0.007004967,
-0.008562375,
-0.011899679,
-0.0059532104,
-0.0044868193,
-0.028613165,
0.007915141,
-0.012782885,
0.026253456,
-0.0036811472,
0.03470796,
0.004608176,
0.006013889,
-0.018216958,
-0.036703598,
0.02982673,
0.014468391,
-0.03211902,
-0.014522328,
0.017178686,
-0.00931074,
0.00412275,
0.027938964,
0.014953817,
-0.028774975,
-0.024824146,
-0.049135897,
0.016153898,
-0.0010070904,
0.026091648,
0.0032142617,
-0.010119784,
-0.00010207851,
-0.01210194,
-0.0064386367,
0.016666293,
-0.0015068433,
0.020563185,
0.0064959438,
-0.0014166686,
-0.024392657,
-0.025376992,
0.023313932,
-0.035517003,
0.0016964627,
0.03397982,
-0.009283773,
-0.008063465,
0.010463627,
-0.0075645554,
-0.008980381,
0.017515788,
-0.0074027465,
0.03098636,
-0.019781109,
-0.0017798954,
0.003650808,
-0.032874126,
-0.008865766,
-0.0014250961,
-0.020792414,
0.001162157,
-0.0292604,
0.031256042,
0.02011821,
0.022019463,
0.007834236,
-0.058305055,
0.003950828,
-0.0054205903,
-0.016774165,
-0.0005667517,
-0.027777154,
0.0017293302,
-0.007557813,
-0.00069358613,
0.013524508,
0.004857631,
0.021372229,
-0.039049827,
0.007038677,
0.012054746,
0.0075510712,
-0.007948851,
-0.01210194,
-0.01871587,
-0.013821157,
0.016450549,
0.029395241,
-0.0065195407,
0.003954199,
0.013834641,
-0.041234244,
0.0052486686,
0.004813808,
-0.008326405,
-0.009695036,
-0.00047531296,
0.013902062,
0.01349754,
-0.0024422996,
0.005845338,
-0.008070207,
-0.003650808,
-0.01177158,
0.027723217,
0.0072544217,
0.0019939546,
-0.005845338,
0.008299436,
0.03341349,
0.013618896,
0.0061453586,
0.03465402,
-0.011994068,
0.0026277052,
0.009074769,
0.010315303,
-0.0051981034,
0.0074364566,
0.016437063,
0.019673238,
-0.015911186,
-0.009115222,
0.014967302,
0.028505294,
-0.002031036,
0.016882038,
-0.0014748186,
-0.023057735,
0.015331371,
0.023556646,
-0.035193384,
-0.024918534,
-0.0015481381,
-0.0054644137,
0.0028906444,
-0.017138235,
0.012283974,
-0.003883408,
-0.0050126975,
0.022666698,
-0.0066139293,
-0.008757894,
-0.010665888,
0.0042946716,
0.008441019,
-0.005595883,
-0.0033170776,
0.0056936424,
0.011077152,
0.008993865,
0.03368317,
-0.017771985,
0.017380947,
-0.008555633,
0.028586198,
-0.018459672,
-0.030851519,
-0.019228263,
-0.009984943,
-0.018931614,
-0.0019770996,
0.023597097,
-0.032739285,
0.08236061,
-0.00219453,
-0.008447761,
-0.014293099,
-0.0007530002,
0.0042677037,
0.00029601716,
0.019794594,
-0.022370048,
-0.026037712,
0.017515788,
0.0053059757,
0.030959392,
-0.02161494,
-0.0012792997,
0.012998629,
-0.023206059,
0.0054677846,
0.005794773,
-0.028640134,
0.00728139,
-0.01725959,
0.0041969125,
0.018136054,
-0.020576669,
-0.0069779987,
0.0122772325,
0.021116031,
-0.0030305416,
-0.04468616,
-0.008582601,
-0.009357935,
-0.04395802,
-0.006822932,
-0.023691487,
-0.015870733,
-0.010982763,
-0.032199923,
0.008798346,
0.0261321,
-0.057711758,
-0.000093334944,
-0.006752141,
-0.023152124,
-0.009175899,
-0.0007521575,
0.021722814,
0.004672225,
-0.033197746
] |
We recently developed a class of novel antitumor agents that elicit a potent growth-inhibitory response in many tumor cells cultured in vitro. WK175, a member of this class, was chosen as a model compound that showed strong in vitro efficacy. WK175 interferes with the intracellular steady-state level of NAD(+), resulting in a decreased cellular NAD(+) concentration. We found that WK175 induces apoptotic cell death without any DNA-damaging effect. The apoptotic death signaling pathway initiated by WK175 was examined in detail: mitochondrial membrane potential, cytochrome c release, caspase 3 activation, | [
-0.022690585,
-0.0112302145,
0.009233281,
-0.023150895,
0.002078165,
0.010553288,
-0.010086209,
0.0058283396,
-0.02208135,
-0.013145918,
0.028864156,
0.023692437,
-0.0030630936,
0.009124973,
-0.0018361638,
0.012218528,
0.032113407,
-0.0050871046,
-0.016313935,
-0.00069046527,
-0.01590778,
0.008184045,
-0.0036655583,
-0.017397018,
0.011764987,
0.022446891,
-0.014865312,
-0.04871165,
-0.011487447,
-0.012320067,
-0.008184045,
-0.012116989,
-0.0025757062,
-0.0062378803,
0.017735481,
-0.01941426,
0.007649272,
-0.030001394,
0.014310231,
0.0024115515,
0.011568679,
0.007940351,
0.0040717144,
0.0035369424,
-0.01616501,
0.0036621739,
-0.0022812432,
-0.0117988335,
0.008745894,
0.029270314,
-0.003183248,
-0.001601778,
0.004196946,
-0.012888686,
0.015542238,
-0.0077508115,
0.018128099,
0.03473988,
-0.012956378,
-0.016408704,
-0.012739762,
-0.0109255975,
-0.04115715,
0.021417962,
-0.004051407,
0.0011702371,
-0.0058723395,
0.01043821,
-0.0011093137,
0.016056703,
0.035443883,
0.033900492,
-0.0071686544,
0.013667151,
0.03178848,
-0.0071212696,
-0.043025464,
0.020497343,
0.0013656997,
0.0075003486,
0.02864754,
-0.014445617,
-0.019211182,
0.020037033,
0.021580426,
-0.0074800407,
-0.035091884,
0.017952098,
0.01876441,
-0.004535409,
0.021986581,
0.016774245,
0.012326837,
0.014174846,
-0.027577996,
0.010248671,
0.00462341,
0.010309595,
-0.004281562,
-0.04364824,
-0.006457881,
-0.016693015,
0.004180023,
-0.01432377,
-0.013024071,
-0.004369562,
-0.0068166526,
0.011900373,
0.027523842,
0.004620025,
-0.03281741,
0.020822268,
0.0102419015,
-0.030326318,
0.011988373,
-0.00915205,
0.03181556,
0.013782229,
-0.0131662255,
-0.031165708,
0.0063935732,
0.01303084,
0.049496885,
-0.028241385,
0.030136779,
-0.010681904,
-0.0071009616,
-0.024978597,
-0.011074522,
-0.0063292654,
0.025845064,
0.027320765,
0.021336732,
-0.007865889,
-0.023611205,
0.028810004,
-0.008075736,
-0.014174846,
-0.019211182,
-0.027591534,
0.009585283,
0.020361956,
0.0009146973,
-0.00452864,
-0.016246242,
0.0015129313,
0.022243813,
0.015853625,
-0.0113656,
0.023340434,
-0.012232066,
-0.025953373,
0.019481951,
-0.012712684,
0.0051784897,
0.013836383,
0.010377287,
-0.000769158,
-0.024003822,
-0.016097318,
0.000731504,
-0.021580426,
0.022704124,
0.00498895,
0.015880702,
0.029514007,
0.0041834074,
0.0015797778,
0.000025107107,
0.0017549326,
0.01395823,
0.019021641,
-0.012252375,
0.017234555,
-0.026264759,
-0.0028870925,
0.017667789,
0.02440998,
-0.007358194,
-0.0018835487,
0.007452964,
0.025493061,
0.0017735481,
-0.009483743,
-0.014757004,
-0.019062258,
0.0045049475,
-0.007520656,
0.005026181,
-0.013531766,
0.00013929883,
0.023516435,
-0.010891751,
-0.019901646,
-0.6433512,
-0.02153981,
0.0021052423,
-0.0009840822,
0.018683178,
0.032871563,
0.03251956,
0.006413881,
-0.004261254,
0.0036147889,
-0.01617855,
0.017613634,
-0.00076873496,
-0.025357677,
-0.017221017,
-0.029622314,
-0.040723912,
-0.023150895,
0.008062198,
-0.0059840325,
-0.013545305,
0.012218528,
-0.029134927,
0.012252375,
-0.012868377,
0.02615645,
0.015474546,
0.001863241,
-0.010180978,
0.043160852,
-0.003530173,
0.033873416,
-0.007865889,
0.008657893,
0.057457544,
-0.0030512474,
-0.0015129313,
0.0064274194,
0.016517013,
0.02856631,
-0.03520019,
0.0057132617,
0.005926494,
-0.01699086,
-0.03501065,
0.0023133971,
0.019346567,
0.010492365,
0.003770482,
-0.0053951065,
0.03501065,
0.016489936,
-0.03658112,
0.018832102,
0.006478189,
0.02569614,
0.006627113,
-0.02504629,
0.010038824,
0.022947818,
0.0058723395,
0.014553925,
0.007818504,
-0.04351285,
-0.03316941,
0.030705398,
-0.011913911,
0.02182412,
-0.0072972705,
0.003482788,
0.020565035,
0.008942203,
-0.01616501,
0.0057437234,
0.020822268,
0.037555896,
-0.0038652518,
-0.005811416,
-0.007865889,
0.019576723,
0.010918829,
-0.021621041,
-0.034360804,
0.0018717025,
0.009639437,
0.00498895,
-0.0061803414,
0.009328051,
0.012164374,
0.003956637,
0.024423517,
-0.014283155,
-0.00093585125,
-0.03866606,
-0.016923169,
0.021702273,
-0.008021582,
0.010180978,
-0.0047181793,
-0.030245088,
-0.019833954,
-0.018371793,
-0.012489298,
-0.016801322,
-0.005632031,
-0.0020917037,
-0.03501065,
-0.010086209,
0.057457544,
-0.01792502,
0.0018124714,
-0.006315727,
0.010945906,
0.0051717204,
-0.0075815795,
-0.019725645,
0.023232127,
0.011379139,
-0.002787246,
-0.045651942,
0.017776096,
0.00038796366,
0.0133963805,
0.004481255,
-0.0048671034,
-0.0018192406,
0.018507177,
-0.0026518605,
-0.0043594083,
-0.012536684,
0.023340434,
-0.0092129735,
0.013640074,
-0.00068961916,
0.02097119,
-0.015203775,
0.0092129735,
-0.016720092,
0.0184801,
-0.02218966,
-0.041509148,
-0.0036452506,
-0.016503474,
0.007236347,
-0.007683119,
0.008278814,
-0.017505325,
0.007987736,
-0.0012049297,
0.007757581,
0.003726482,
0.0041732537,
-0.012584069,
0.018087484,
0.03243833,
-0.009856054,
-0.020185957,
-0.025032751,
0.005452645,
-0.0063969577,
-0.0055406457,
0.0067760367,
-0.009077588,
0.012996994,
-0.0091791265,
-0.022825971,
0.027970614,
0.0069452687,
0.0056624925,
-0.022825971,
-0.022880124,
-0.007744042,
-0.012509607,
0.00878651,
0.010214825,
0.004697872,
0.002152627,
0.0018310869,
-0.004169869,
0.008400661,
-0.003963406,
-0.00034480958,
-0.01303084,
-0.01590778,
0.0068640374,
0.012929301,
0.011981604,
0.018141637,
-0.017031478,
0.023909053,
-0.011676987,
0.017789636,
-0.0035200191,
0.01533916,
0.0041089454,
0.008407431,
0.0047249487,
-0.0004459255,
0.021593964,
0.051256895,
-0.0013310072,
-0.0063935732,
0.014905928,
-0.013335457,
0.024897367,
-0.0047926414,
-0.0037738667,
-0.013044379,
0.031653095,
0.010106517,
0.003540327,
0.022622893,
-0.021512732,
0.00015188544,
0.010485595,
-0.0070129614,
-0.009314512,
-0.011697294,
-0.0036215582,
-0.039505444,
0.01173791,
-0.026183527,
0.0025486292,
-0.008488662,
-0.008244968,
-0.0038381747,
0.013443765,
0.03918052,
-0.013917614,
-0.017153325,
-0.015975472,
-0.01709917,
0.013687459,
-0.012760069,
0.020903498,
-0.010451749,
0.0054120296,
-0.005232644,
0.040507298,
-0.017397018,
-0.016584706,
-0.0054120296,
0.010289287,
0.017288709,
0.015555777,
-0.0017041632,
0.03855775,
0.011927449,
-0.017613634,
0.00720927,
-0.0031087862,
0.024166286,
-0.0144591555,
0.018087484,
-0.009998208,
-0.015934857,
0.003139248,
0.031301092,
0.03834113,
0.02763215,
0.028214308,
-0.030651243,
0.0019106258,
-0.010309595,
0.0018497023,
0.0064680353,
0.0067421906,
0.00018573178,
-0.008353276,
0.011825911,
-0.0043661776,
-0.018358253,
0.021742888,
-0.021417962,
0.022379199,
0.0003513673,
0.02357059,
0.005510184,
0.0109255975,
0.000827966,
-0.0048366417,
-0.015041312,
0.027550919,
0.025344137,
-0.0113046765,
-0.010384057,
-0.043106697,
-0.005330798,
-0.004843411,
0.030028472,
-0.0092535885,
0.018344715,
0.0068911146,
0.022257352,
-0.003753559,
-0.02772692,
0.014581002,
-0.038584825,
-0.0030901707,
-0.016882554,
0.016841939,
-0.0034421727,
-0.009801899,
0.022825971,
0.01885918,
-0.008718817,
-0.0010483903,
-0.0034032492,
0.0044677164,
0.001463008,
-0.008630816,
0.0072228084,
0.009077588,
0.0018158561,
-0.0057911086,
-0.0010433134,
0.010004978,
0.007892966,
0.005327414,
-0.007608657,
0.0068064984,
-0.025154598,
-0.0065391124,
-0.02560137,
0.035416808,
0.033954646,
0.0055338764,
0.003012324,
0.0017600096,
0.017586557,
0.0084142,
-0.024288133,
0.00804189,
-0.019901646,
-0.008468354,
-0.005977263,
0.019400721,
-0.0044880244,
-0.0065797283,
0.017870866,
0.00021397232,
-0.028918311,
-0.000785235,
-0.010221594,
0.018981026,
-0.021377347,
0.03159894,
0.034252495,
-0.0034607882,
0.01441854,
0.026400143,
0.029270314,
-0.009950823,
-0.008739124,
0.018182253,
0.005256336,
0.005906186,
0.019143488,
-0.0063461885,
-0.022798894,
0.0036114042,
0.038205747,
0.022149043,
-0.021282578,
0.028322617,
0.00025003983,
0.010695443,
-0.0065086507,
-0.0029818623,
0.010939136,
0.028322617,
0.0014249309,
-0.020199494,
-0.031192785,
0.029459853,
-0.027496764,
-0.024965059,
-0.021499194,
-0.006820037,
0.027225994,
-0.010891751,
0.009199435,
0.0036452506,
-0.0074055786,
0.00831266,
-0.0399116,
0.012428375,
-0.009971132,
-0.0013386226,
0.003807713,
-0.025086906,
-0.0109255975,
-0.005720031,
-0.019278875,
0.024206901,
0.004565871,
-0.014811157,
0.01839887,
-0.011616063,
0.0075680413,
0.0005263106,
-0.02228443,
-0.022717662,
0.0225552,
0.002675553,
0.0049787965,
-0.011399447,
-0.043269157,
0.0047926414,
0.008712048,
-0.00022338582,
-0.033954646,
-0.0071415775,
-0.0044541783,
-0.0067388057,
0.0017329325,
0.015203775,
-0.014946543,
-0.015244391,
-0.0017583172,
0.010404364,
0.031003246,
-0.00036765586,
0.0068978835,
0.02430167,
-0.013484381,
-0.0037501743,
-0.016869014,
-0.0077237342,
-0.027577996,
0.014120692,
0.0255066,
-0.02625122,
0.00397356,
-0.0032864795,
0.0033863261,
0.007358194,
-0.007134808,
0.010790213,
0.032844488,
0.0047554104,
0.034956496,
-0.01007944,
-0.0015772394,
-0.016016087,
-0.0074732713,
0.01627332,
-0.0017718558,
-0.021093037,
-0.0068809604,
-0.02607522,
-0.0060517252,
-0.00060119556,
-0.009091127,
-0.019075796,
0.018182253,
-0.00038965596,
-0.040534373,
-0.007892966,
0.00008763029,
-0.00961236,
-0.004555717,
0.010844367,
-0.024518287,
-0.012069604,
0.0034963267,
0.014215462,
-0.007270193,
-0.0071212696,
-0.026345989,
-0.013321918,
0.015501623,
-0.00628188,
-0.0009206204,
-0.017031478,
-0.0029344775,
-0.029189082,
-0.014296693,
-0.02171581,
-0.03482111,
-0.016611783,
0.013876999,
0.02144504,
0.022677047,
0.01941426,
-0.012144066,
0.021093037,
0.011947758,
0.0049923346,
0.005002489,
-0.011629602,
0.011670217,
-0.008867741,
0.04519163,
0.004031099,
-0.013606228,
0.017911483,
-0.013518227,
0.0266303,
0.0297577,
-0.017681327,
-0.011534832,
-0.005093874,
-0.025019214,
-0.01562347,
0.013159457,
-0.009666515,
-0.014770542,
-0.019563183,
-0.0070264996,
0.017234555,
0.02005057,
0.003193402,
0.001319161,
0.0020257034,
-0.017721942,
0.0089489715,
-0.010553288,
0.008515739,
-0.010851136,
-0.008515739,
0.013646844,
-0.0042646388,
0.0036114042,
-0.0048027956,
-0.009740976,
0.018412407,
-0.042375617,
-0.0054864916,
0.010160671,
-0.016341012,
-0.014364386,
-0.009964362,
-0.012028988,
-0.020361956,
-0.005212336,
-0.013816075,
-0.025885679,
-0.0020815497,
0.0098628225,
-0.016517013,
-0.015555777,
0.00030673243,
-0.024369363,
0.03574173,
-0.007757581,
0.024220439,
-0.014770542,
0.040507298,
0.020700421,
-0.003641866,
-0.020551497,
-0.00198678,
-0.023421666,
0.025493061,
0.010120055,
0.025276445,
-0.020713959,
-0.0013233918,
-0.010824059,
0.03149063,
-0.030732475,
-0.027212456,
0.01969857,
-0.003567404,
0.020673344,
-0.02404444,
0.0023150896,
-0.03872021,
0.027781075,
0.0024335517,
-0.009314512,
-0.005202182,
-0.025736755,
-0.02404444,
0.0314094,
0.008508969,
0.01220499,
-0.0015823164,
-0.020754574,
-0.0035910965,
-0.036093734,
0.0027229378,
0.011128676,
-0.010059131,
0.013836383,
-0.020294264,
0.014337309,
0.008712048,
0.014052999,
0.019644415,
0.0010856213,
-0.004315408,
0.03771836,
0.0021052423,
0.015609931,
0.033521414,
-0.012062835,
-0.00006388496,
-0.017248094,
-0.014919465,
-0.015488084,
-0.033061102,
0.0041664843,
0.018723793,
0.019441336,
0.010350211,
-0.0037637127,
-0.018466562,
-0.0048027956,
-0.023029048,
-0.028593386,
0.018263483,
-0.03649989,
0.00042582923,
-0.011453601,
-0.0075545027,
0.016286857,
0.00512772,
-0.008116351,
0.006044956,
0.027686305,
-0.016787784,
0.012611145,
0.021607501,
0.0052258745,
-0.019509029,
0.0077034268,
-0.008617277,
-0.03855775,
0.017721942,
-0.016801322,
-0.054289527,
-0.023367511,
-0.015772393,
0.020118263,
0.021106577,
-0.0032374023,
0.027280148,
0.019035181,
0.007926812,
0.009652976,
-0.018791487,
0.0068877297,
-0.020226572,
0.032844488,
0.02875585,
-0.007825273,
-0.02041611,
-0.0039024828,
-0.012631454,
0.007161885,
-0.01460808,
-0.022379199,
-0.026738606,
-0.00522249,
-0.0042037154,
-0.005767416,
0.00794712,
-0.018886257,
-0.02366536,
0.017234555,
0.009165589,
-0.02856631,
-0.0122929895,
-0.027645689,
0.001741394,
0.002392936,
-0.010796982,
-0.01662532,
-0.0066474206,
-0.025669063,
-0.028430924,
0.012238836,
-0.0045624864,
0.025669063,
0.0018564716,
-0.0053680292,
-0.025845064,
-0.01044498,
-0.042863004,
0.0053680292,
-0.016841939,
0.015393315,
-0.016395167,
0.026955223,
-0.02060565,
-0.00011433716,
-0.00022084736,
-0.0015171621,
-0.011257292,
-0.027672766,
0.02431521,
-0.020402573,
0.03273618,
-0.018981026,
-0.032682024,
0.00022930893,
0.028945388,
-0.0042578694,
-0.037880823,
0.02983893,
-0.0025520138,
0.0011761603,
-0.00026675145,
0.012421606,
-0.0068064984,
0.020118263,
0.010918829,
-0.022433354,
-0.009639437,
-0.0006083879,
-0.009483743,
-0.0040581757,
-0.00058342627,
0.009300973,
0.015136083,
0.0020121648,
-0.012685607,
-0.042321462,
-0.0046741795,
0.002078165,
0.010059131,
0.024829675,
-0.008292353,
0.01755948,
0.013003763,
-0.023787206,
-0.013423458,
-0.02145858,
-0.019536106,
0.004660641,
0.024883827,
0.008082505,
-0.005418799,
-0.00072219624,
0.028160153,
-0.029324466,
-0.005432337,
-0.013728075,
-0.0053003365,
-0.01349115,
0.020294264,
0.0134708425,
0.015609931,
-0.0058554164,
0.017911483,
-0.0003668097,
-0.016462859,
-0.0112302145,
0.010688674,
-0.011203138,
-0.016584706,
0.0021103192,
-0.010776674,
0.0035775579,
-0.017613634,
-0.0011753141,
0.0020257034,
0.013734844,
0.20351127,
0.000998467,
0.033034027,
0.0043120235,
0.005114182,
-0.0060855714,
0.0150683895,
0.00812989,
-0.008996356,
-0.008651124,
0.03939714,
0.009003126,
-0.008718817,
-0.0027973999,
-0.0036655583,
-0.01154837,
-0.024017362,
-0.010323133,
-0.029324466,
0.00037675205,
0.008901587,
0.0031443248,
0.017681327,
-0.0020917037,
0.015609931,
0.0071957316,
-0.026373066,
0.00730404,
0.008028352,
-0.0037738667,
-0.036310352,
0.010451749,
0.006644036,
-0.0023320126,
-0.0013919306,
-0.02512752,
-0.03937006,
-0.03918052,
0.013321918,
0.0021746273,
-0.0047587953,
0.0031730942,
-0.027510304,
-0.00020498189,
-0.0055135684,
0.009585283,
-0.002663707,
-0.02208135,
0.0017041632,
0.003743405,
-0.03357557,
0.004972027,
0.050959047,
0.019008104,
-0.00071035,
0.013342227,
-0.00007451483,
-0.0068911146,
0.0015078543,
0.046599638,
-0.03503773,
-0.011399447,
-0.025032751,
0.017586557,
0.004860334,
0.027496764,
-0.019346567,
-0.015203775,
0.029595237,
-0.016192088,
0.015176698,
-0.0091791265,
-0.02837677,
0.005537261,
-0.0010593904,
-0.021431502,
0.024951521,
0.017721942,
0.016706552,
-0.0007606964,
0.028268462,
-0.0017320863,
-0.012969917,
0.019996416,
-0.023651822,
-0.015176698,
0.0031257092,
0.019928724,
-0.012969917,
0.017816713,
-0.0026958608,
0.008272045,
-0.010519442,
0.0042578694,
0.0066508055,
-0.010891751,
0.008461584,
-0.002970016,
0.011176061,
-0.02060565,
-0.023069665,
0.076032415,
-0.025398292,
0.005537261,
-0.021742888,
0.018696718,
-0.0017481634,
0.0012311606,
0.0034472495,
0.00046750254,
0.017261632,
-0.032871563,
0.011704064,
-0.008908357,
0.0031054015,
0.01460808,
-0.008062198,
-0.02616999,
0.020037033,
-0.030055549,
0.006231111,
-0.04603102,
-0.0057708006,
0.034144185,
0.009036972,
0.025005674,
-0.03614789,
-0.014635157,
-0.0036147889,
-0.018371793,
0.004169869,
0.0034692497,
-0.008522508,
0.027280148,
0.014337309,
0.0025655525,
0.012313298,
0.01460808,
-0.0076289647,
0.012441914,
-0.011284369,
-0.013592689,
-0.011717603,
0.016611783,
0.015325622,
-0.00031286708,
0.02052442,
0.0061295717,
-0.0053747986,
-0.027605074,
-0.0009062357,
-0.023083203,
-0.014946543,
-0.0029514006,
0.026603222,
-0.008630816,
-0.027442612,
-0.011033907,
0.012191451,
0.026697991,
-0.0253306,
-0.011812372,
0.027943537,
-0.014567464,
-0.021797042,
0.00924682,
-0.17242679,
0.020118263,
0.02579091,
-0.025993988,
0.05886555,
0.026549067,
0.0044169473,
-0.0137754595,
-0.018791487,
0.005296952,
0.010959445,
-0.011852988,
-0.014012384,
-0.018832102,
0.0069723455,
-0.0024013978,
-0.00452864,
0.03465865,
0.009808669,
0.01395823,
0.009402513,
-0.0046335636,
0.009287436,
0.009104665,
-0.0062074186,
0.030570013,
-0.014499771,
-0.035173114,
0.0037129433,
0.010356979,
-0.021932427,
0.000998467,
-0.0013470843,
0.00914528,
0.015542238,
0.008062198,
0.002061242,
0.0028210923,
-0.00054661836,
0.03449619,
0.031571865,
0.0146486955,
0.00022190505,
-0.0154068535,
-0.035633426,
0.031111553,
0.011514524,
0.0058046468,
-0.00040890608,
-0.020659804,
0.007344655,
-0.023164434,
0.0065797283,
0.016571168,
0.022230275,
0.0050972584,
0.00896251,
-0.0067421906,
-0.0035132498,
-0.012502837,
0.0078861965,
-0.010681904,
0.01875087,
-0.009666515,
0.022880124,
-0.03411711,
-0.018642563,
-0.0029277082,
-0.013376073,
-0.0017016246,
-0.04603102,
-0.010485595,
0.021553349,
-0.0077305036,
0.010465288,
0.0047824876,
0.0116092935,
0.011406216,
-0.002536783,
0.017992713,
-0.00086392777,
0.017640712,
-0.018981026,
-0.0037129433,
-0.0070129614,
0.0029547852,
0.01912995,
0.019062258,
-0.006999423,
0.00026082835,
0.012096682,
-0.019847492,
0.0043458696,
-0.023922592,
0.021228423,
0.020862883,
-0.01441854,
0.00415633,
-0.022094889,
0.003005555,
0.018534254,
-0.015041312,
0.0111895995,
0.010248671,
0.02690107,
0.016029626,
-0.028891234,
0.0047080256,
0.034171265,
-0.0017007785,
-0.016950246,
0.0039701755,
-0.00896251,
0.012746531,
-0.01072929,
0.028728772,
-0.003743405,
-0.0050227963,
-0.024613056,
-0.031734325,
0.060327712,
0.008840663,
-0.012692377,
0.0064172656,
0.00545603,
-0.026291836,
-0.11989727,
-0.028674617,
-0.0020443187,
0.01765425,
-0.012191451,
0.031355247,
0.00022423199,
0.024085054,
-0.013592689,
0.016950246,
0.0035437115,
-0.02263643,
0.0025520138,
0.00586557,
0.0127533,
0.0062514185,
0.016693015,
0.007899735,
-0.014310231,
0.04207777,
-0.021417962,
-0.004877257,
-0.014757004,
-0.0035944812,
0.004356024,
-0.009740976,
-0.015271468,
0.02208135,
0.020213034,
0.021621041,
0.0060009556,
0.004014176,
0.027997691,
0.00471141,
-0.031219862,
-0.012279452,
-0.027198918,
-0.022446891,
0.025357677,
-0.025723217,
0.001490085,
0.013734844,
0.0012201605,
0.0030664783,
0.0058351085,
0.0038618671,
-0.00730404,
-0.001506162,
0.010289287,
0.0012057758,
-0.011954526,
0.000007450161,
-0.02301551,
-0.0032864795,
0.015637008,
-0.02596691,
0.04066976,
0.017085632,
-0.028485078,
-0.0014943158,
-0.0063292654,
-0.00014998158,
-0.010715751,
-0.028024768,
0.03197802,
0.0076289647,
-0.023881976,
-0.007940351,
0.025195215,
-0.004176638,
-0.008380353,
-0.008272045,
-0.019211182,
0.01895395,
-0.031274017,
-0.009043742,
-0.005239413,
0.004535409,
0.016787784,
-0.006928345,
-0.026129372,
-0.016530551,
0.0006583113,
-0.013822844,
0.040805146,
-0.015312083,
0.012922532,
-0.0025249368,
0.007818504,
-0.012529914,
-0.029595237,
0.01801979,
-0.007439425,
-0.027699843,
-0.011670217,
-0.0021763195,
0.016056703,
-0.008075736,
0.017072093,
0.022825971,
0.0011685449,
-0.02006411,
-0.059732016,
0.023638282,
-0.011521294,
-0.00224232,
0.009476975,
-0.012536684,
-0.005110797,
0.0035234038,
0.011866526,
0.009314512,
-0.021282578,
0.01460808,
-0.00112116,
0.00924682,
-0.033629723,
-0.01468931,
0.011866526,
0.0075477334,
0.019427799,
0.026386606,
0.004928027,
-0.016584706,
0.02910785,
0.0012878531,
-0.013355765,
-0.028105998,
-0.018222868,
0.0050295657,
0.00794712,
0.00077338883,
0.008360046,
-0.039667908,
-0.017437633,
0.0036147889,
-0.010174209,
0.004213869,
-0.00448464,
0.034902345,
0.01793856,
0.015041312,
-0.018128099,
-0.017275171,
0.0050803353,
0.012191451,
-0.015637008,
0.009064049,
-0.008725586,
0.015014236,
0.0061295717,
-0.012225297,
0.028999543,
0.005523722,
-0.012929301,
-0.024897367,
-0.043187927,
0.022135505,
-0.015731778,
-0.025005674,
-0.0030614012,
-0.0050871046,
-0.003939714,
-0.006190495,
0.014594541,
0.012035758,
0.024206901,
-0.014134231,
-0.0157047,
-0.010790213,
0.01322038,
-0.013579151,
-0.015948394,
-0.009036972,
0.01820933,
-0.015853625,
0.0041461764,
-0.0059468015,
-0.019603798,
-0.0036621739,
-0.021945966,
0.014120692,
0.009856054,
-0.004917873,
-0.032384176,
0.00050727197,
0.01979334,
0.0058249547,
-0.00591634,
0.015109005,
-0.0021018577,
-0.00041165607,
0.010932367,
0.012550222,
-0.0018733948,
0.004031099,
-0.008272045,
0.01109483,
-0.013172994,
-0.004613256,
0.005212336,
0.01866964,
0.0011668525,
0.013816075,
-0.00088338944,
0.0008080813,
-0.011616063,
-0.0048163338,
-0.019969339,
-0.024233978,
-0.018832102,
-0.01579947,
0.024829675,
0.02263643,
-0.0051886435,
0.014107154,
-0.0023726283,
0.036391582,
0.013788998,
0.009964362,
-0.021485655,
0.038882673,
0.01811456,
0.015176698,
0.009226512,
-0.000395156,
0.02200012,
0.0056421845,
0.025100444,
-0.0067252675,
0.031274017,
-0.019536106,
0.034550343,
-0.012299759,
-0.022419814,
0.004010791,
-0.0007615426,
0.0018717025,
0.016517013,
0.0008901587,
-0.016232703,
0.07814442,
0.01941426,
-0.022297967,
-0.0039532525,
-0.0048197187,
0.0042578694,
0.020808728,
0.0058215703,
0.00047215642,
-0.028078921,
-0.00012851032,
-0.02791646,
0.024112131,
-0.024572441,
-0.022825971,
0.0007886197,
-0.011446832,
0.0108105205,
0.01884564,
-0.023624744,
0.015163159,
0.0041732537,
-0.0030952475,
0.02171581,
-0.027577996,
-0.019549645,
0.012651761,
-0.011927449,
-0.0054864916,
-0.032952793,
-0.012245605,
0.014120692,
-0.021296116,
-0.013348996,
-0.005885878,
-0.02468075,
-0.0017346248,
-0.027320765,
0.015041312,
0.012502837,
0.0020680113,
0.033494335,
-0.021120114,
-0.042267308,
0.022460429,
0.0045794095,
-0.016435781,
-0.014729926,
-0.0052461824
] |
BACKGROUND A primary cause of high maternal mortality in Bangladesh is lack of access to professional delivery care. Examining the role of the family, particularly the husband, during pregnancy and childbirth is important to understanding women's access to and utilization of professional maternal health services that can prevent maternal mortality. This qualitative study examines husbands' involvement during childbirth and professional delivery care utilization in a rural sub-district of Netrokona district, Bangladesh. METHODS Using purposive sampling, ten households utilizing a skilled attendant during the birth of the youngest child were selected and matched with ten households utilizing an untrained traditional birth attendant, or dhatri. Households were selected based | [
-0.0037990455,
0.002887207,
-0.017838996,
-0.045952607,
-0.0011638158,
0.0044058138,
-0.018459247,
0.01612656,
-0.027048394,
-0.019605367,
-0.0072475136,
0.022517856,
-0.010308323,
0.012290434,
-0.018567119,
-0.0005646319,
0.04107149,
-0.015182698,
0.0039439956,
-0.021681864,
-0.025322475,
0.0056867697,
0.004200187,
0.02412242,
0.0020832387,
0.021695348,
0.014629864,
-0.030284494,
-0.0016559726,
-0.009667845,
-0.014791669,
0.0024186468,
-0.022018958,
-0.038887125,
-0.031255323,
-0.008252053,
-0.000006728705,
-0.0019382884,
0.0035394833,
0.001980425,
0.02076497,
-0.009519525,
0.009512783,
0.0056429477,
-0.0009565032,
0.010099325,
0.0015809692,
-0.011380281,
-0.03416781,
0.0074093184,
0.016423203,
0.009688072,
-0.025942728,
0.020576196,
0.010321807,
0.010153261,
-0.01698952,
0.010031907,
0.014939991,
-0.004995728,
-0.007780121,
0.0135916155,
-0.022706628,
0.002155714,
-0.03341272,
-0.0051609036,
-0.015317535,
0.0108139645,
0.01504786,
0.019025566,
0.03894106,
0.027992256,
0.0064384886,
-0.006957613,
0.025996663,
-0.0014520308,
-0.03236099,
0.004830552,
-0.020724518,
0.00428446,
-0.0016492307,
-0.0036473533,
0.007699219,
0.024162874,
-0.010955543,
-0.00017960771,
-0.010240905,
0.030446298,
0.00457099,
-0.020994192,
0.011784794,
0.006101395,
0.030014819,
0.021600962,
0.010537547,
0.026657365,
-0.011319605,
0.04322889,
0.008070022,
-0.015641145,
-0.03292731,
0.003654095,
-0.02321901,
-0.011272412,
-0.0030355284,
0.0018961518,
-0.018364862,
-0.0316059,
0.0245539,
-0.013005073,
-0.025012348,
0.022504373,
0.0025079767,
-0.018486215,
0.007112676,
-0.019430079,
0.005622722,
-0.016517589,
-0.007962152,
-0.000928693,
0.005090114,
0.013099459,
0.014454575,
0.0051676454,
-0.008157666,
-0.010591483,
-0.03009572,
-0.014063547,
0.01371297,
-0.009870102,
-0.020872839,
0.018216541,
0.00017518336,
0.0006526976,
-0.0117982775,
0.015614178,
-0.03009572,
-0.03225312,
-0.029637273,
-0.02634724,
0.0023781958,
0.021641413,
-0.0032984614,
-0.0075778654,
-0.005747447,
0.032307055,
0.030662037,
0.01720526,
-0.012229757,
0.018917695,
-0.0024186468,
-0.03624431,
-0.018513184,
-0.011090381,
0.005730592,
0.009317269,
-0.003819271,
0.019214338,
-0.01227695,
-0.022827981,
0.020508777,
0.006094653,
-0.0051238234,
-0.016625458,
0.010524063,
0.01832441,
-0.014171417,
0.016247913,
0.017218744,
-0.017245712,
0.0035597088,
0.024796609,
-0.027830452,
-0.0018708698,
-0.0032563247,
0.0004681388,
-0.0032580101,
0.032873373,
-0.028531607,
-0.009762232,
-0.048757225,
0.005565416,
0.021155998,
0.03330485,
-0.032091316,
-0.014427608,
0.01688165,
-0.019861558,
0.007834056,
0.014117482,
0.0084206,
0.031551965,
-0.008764435,
-0.009074561,
-0.6446309,
-0.0233943,
0.014778186,
0.0008347281,
-0.020886322,
-0.0017031657,
0.02033349,
0.00021331708,
-0.007429544,
0.042527735,
-0.0063002803,
0.037673585,
-0.008049796,
-0.0133354245,
-0.016099593,
-0.0129511375,
-0.010766771,
0.0042204126,
0.0031113743,
-0.031632867,
0.0064755687,
0.004722682,
0.0061519593,
0.011946599,
-0.017003004,
0.009148722,
0.017124357,
0.0037383686,
-0.009155463,
0.052829318,
-0.005238435,
0.039102864,
0.001169715,
0.032657634,
0.04754369,
-0.028100127,
-0.022841465,
0.025605634,
0.0059800413,
0.018135639,
-0.025538215,
-0.042743474,
0.015627662,
-0.0057508177,
0.006165443,
0.01731313,
0.022329083,
-0.017663708,
0.0046957145,
0.0031872205,
-0.013847807,
-0.009856618,
-0.01709739,
-0.012978106,
-0.01177131,
0.0001546417,
0.018836793,
-0.038509578,
0.0073958347,
-0.0008848708,
-0.0015573726,
-0.002037731,
-0.0030119317,
-0.014575929,
-0.037943263,
0.041476004,
-0.0049181962,
0.023933649,
-0.016571524,
-0.0023242608,
-0.004631667,
0.03654095,
-0.004628296,
-0.0070115477,
0.030608103,
0.029556371,
0.0049451636,
0.00457099,
0.009438622,
-0.015425405,
0.020293038,
-0.009283559,
-0.009013884,
-0.028154062,
0.017340098,
-0.005835091,
-0.011326347,
0.0039777053,
-0.006489053,
-0.003499032,
0.0074093184,
0.00410243,
-0.003283292,
-0.0014107369,
0.008622856,
0.032522794,
-0.0011090381,
-0.0012598875,
0.042419866,
-0.0090004,
-0.02584834,
0.0010896552,
-0.0069845803,
0.011906148,
-0.0023242608,
0.018014284,
-0.029799078,
0.0068767103,
0.03686456,
-0.0141444495,
0.0037956745,
0.0036372405,
0.014306255,
-0.008771176,
0.025969695,
-0.024661772,
-0.0077666375,
0.015856884,
0.013092717,
-0.011272412,
0.012614044,
-0.007705961,
0.017299647,
-0.025039317,
0.007975636,
0.026913557,
0.004095688,
0.0021759395,
0.027291102,
0.0056564314,
-0.025335958,
0.0041058008,
0.037646618,
-0.005029437,
0.02242347,
-0.006532875,
0.018594086,
-0.032307055,
0.0008225085,
-0.00091942295,
0.0034788065,
0.011757826,
0.009506041,
-0.020711035,
0.005417095,
-0.034248713,
-0.016423203,
-0.011467926,
-0.0006653386,
0.003404646,
-0.013396102,
-0.02019865,
0.0011478039,
0.018189574,
-0.00072180177,
-0.0071531273,
-0.0030321574,
-0.013294973,
0.002393365,
-0.008252053,
0.0109892525,
0.022059409,
-0.04460423,
0.009897069,
0.005629464,
-0.03751178,
0.004311428,
0.00134079,
0.015398438,
-0.020778453,
0.0048575196,
-0.033089112,
-0.0070317737,
0.029259728,
-0.0038866897,
0.020670582,
-0.0071868366,
0.030473266,
-0.016827716,
0.006957613,
0.021830184,
-0.017164808,
-0.015438889,
-0.012984848,
0.01860757,
0.009897069,
-0.003556338,
-0.012405046,
0.0074699954,
0.009472332,
-0.011980308,
0.016477138,
-0.004399072,
0.029124891,
0.012587077,
-0.0032478974,
-0.0056126094,
0.015223149,
-0.019133436,
0.019794138,
0.038024165,
0.009445364,
0.038105067,
0.00903411,
0.018931178,
-0.013618584,
-0.0048406646,
0.005201355,
0.014387157,
-0.016854683,
-0.0060710567,
-0.033898138,
0.010153261,
-0.014171417,
-0.0058688005,
0.016760295,
-0.024216808,
0.0034552098,
-0.017151324,
0.013834324,
0.005349676,
-0.01746145,
0.03751178,
0.007982378,
-0.018621054,
-0.00471594,
-0.0074632536,
0.002732144,
0.018661505,
-0.0006025549,
-0.0060272343,
0.036379147,
-0.0055991253,
0.022720112,
-0.011151058,
-0.018027768,
0.0017427742,
-0.02058968,
0.02468874,
-0.013726453,
-0.0022972932,
0.0018388459,
0.0037215138,
-0.01871544,
-0.0037585942,
-0.008541953,
0.029637273,
0.010894867,
0.0120949205,
0.012755624,
0.004412556,
0.012155597,
-0.0168412,
0.011670182,
-0.0045541353,
-0.02890915,
-0.006168814,
0.0016273196,
0.033790268,
-0.0035091448,
0.025673052,
0.015169214,
0.003055754,
-0.009802683,
0.0017427742,
-0.0084273415,
0.0075441557,
0.0010576313,
-0.020616647,
-0.036082502,
-0.00827902,
-0.0032950905,
0.014103998,
-0.022774046,
0.007159869,
0.016220946,
0.013348908,
0.0114544425,
0.015425405,
-0.007840798,
-0.04643802,
-0.01806822,
0.016261397,
0.016153527,
-0.016113076,
-0.013847807,
-0.0047260527,
0.018782858,
-0.013477004,
0.024796609,
0.018270476,
-0.0073688673,
0.0058991387,
-0.016571524,
0.00964762,
-0.0029293438,
0.034868967,
-0.00914198,
0.028234964,
-0.008292504,
0.010719578,
-0.013955677,
-0.032010414,
-0.011063414,
0.022383017,
0.009243107,
-0.006789066,
-0.01785248,
0.0014503454,
-0.017340098,
0.00019435555,
-0.012445497,
-0.011184767,
0.009607169,
0.004884487,
-0.0036945464,
-0.0021152627,
0.037808422,
-0.0072475136,
0.00798912,
-0.009816167,
-0.0071194177,
-0.0050125825,
0.0076183164,
0.09541099,
0.0035259996,
-0.0042237835,
0.019389628,
0.007746412,
-0.014279287,
-0.009829651,
-0.020266071,
0.025780922,
0.013220813,
0.023663973,
-0.028100127,
0.0011722432,
-0.00067334453,
-0.00336588,
0.007382351,
0.008528469,
-0.018081704,
-0.002491122,
-0.0019922236,
0.0074430276,
-0.015344502,
0.01832441,
0.0067620985,
0.0074632536,
-0.003300147,
0.012769108,
0.023448234,
0.008218343,
-0.006098024,
0.0088116275,
0.027102329,
-0.025538215,
0.0491078,
-0.01349723,
0.018567119,
0.01206121,
-0.017771577,
0.01731313,
-0.0013138225,
0.010106067,
0.024648288,
0.01249269,
0.002098408,
0.017677192,
-0.004887858,
0.006098024,
0.01640972,
-0.010240905,
-0.0050665177,
0.035327416,
0.010213938,
-0.0077194446,
-0.03203738,
0.021317802,
0.0011874124,
0.020845871,
-0.005821607,
-0.00075677526,
-0.0029832788,
-0.01951098,
-0.012836526,
0.025133703,
-0.011151058,
-0.0119263735,
-0.016369268,
-0.033844203,
0.0004656106,
-0.013268006,
0.0058553168,
0.01072632,
-0.0058620586,
-0.027291102,
-0.000774894,
0.015101795,
0.0055788998,
0.01731313,
-0.014225352,
-0.008198118,
0.024702223,
-0.013477004,
0.0049721315,
-0.005996896,
-0.025470797,
-0.025430344,
0.008029571,
-0.00986336,
-0.040990587,
-0.019403111,
-0.00392377,
0.00027936636,
0.0005229165,
0.002513033,
-0.004291202,
-0.00017729019,
0.04452333,
-0.010995995,
0.0054339496,
-0.0077194446,
-0.02677872,
0.006593552,
-0.035839796,
-0.02425726,
0.010564515,
0.02774955,
0.0004769875,
-0.026522528,
-0.0033709365,
-0.0065059075,
-0.024675256,
0.037916295,
-0.018405313,
0.020724518,
-0.01392871,
0.025106736,
0.03848261,
0.0027085475,
0.040936653,
0.020549228,
-0.005926106,
0.0005553618,
0.0012860122,
0.016086109,
0.0120949205,
-0.02321901,
-0.0002840014,
0.01670636,
-0.033143047,
-0.036325213,
-0.020293038,
0.0050564045,
0.015277084,
-0.0034383552,
-0.03405994,
-0.020616647,
0.00028463345,
-0.02037394,
0.009984714,
-0.022288632,
-0.009607169,
-0.007645284,
-0.0077261864,
0.011703892,
-0.030742941,
0.04268954,
-0.03357453,
0.009829651,
0.0029967625,
-0.021911087,
0.016652426,
-0.012674721,
-0.00957346,
-0.016436687,
-0.00027978772,
-0.028747346,
-0.023933649,
0.0010087527,
-0.006846372,
0.03904893,
0.012263467,
0.035516188,
0.002979908,
0.014441092,
-0.009007142,
0.011407249,
0.012485948,
-0.0074767373,
-0.0024203323,
-0.030985648,
0.02656298,
0.028936118,
0.0051305653,
0.0018017655,
0.01483212,
0.015398438,
0.008872305,
-0.01727268,
-0.047274012,
-0.005359789,
-0.01666591,
-0.014751218,
-0.019389628,
-0.03020359,
-0.00075003336,
-0.04438849,
-0.0025720245,
0.029259728,
-0.007267739,
0.002598992,
-0.011596021,
0.001854015,
-0.0062328614,
0.027992256,
-0.002678209,
-0.0076250583,
-0.0133354245,
0.0043653627,
-0.014913023,
0.016571524,
0.022814497,
-0.001774798,
0.019740203,
0.011097123,
-0.0071935784,
-0.018405313,
0.026306788,
-0.016423203,
-0.0053294506,
0.031147454,
-0.017717643,
-0.019686269,
-0.009681329,
-0.016800748,
-0.042959213,
-0.017501902,
0.0053328215,
-0.006563213,
0.028666444,
-0.006890194,
-0.0023967358,
-0.019524464,
-0.00460807,
0.008521727,
-0.013996128,
0.016800748,
-0.0014983813,
-0.02977211,
0.0014334908,
0.009411654,
0.0005330293,
0.0001437915,
0.019645818,
0.0075778654,
0.0022012214,
-0.03292731,
0.0070452574,
0.020994192,
-0.018944664,
-0.016962552,
0.028019223,
0.0062867966,
-0.0152096655,
0.011724117,
0.0019922236,
-0.018162606,
-0.0018995227,
0.00047488068,
0.0034316133,
0.006374441,
-0.023596555,
-0.014387157,
-0.019605367,
-0.051777583,
0.019996395,
0.011805019,
-0.014050064,
-0.005845204,
-0.009074561,
-0.03236099,
0.0016660853,
-0.011852212,
0.018701956,
-0.00892624,
0.023097657,
-0.00037269917,
0.007490221,
-0.015088311,
0.00431817,
-0.017367065,
0.03646005,
0.012647754,
0.005710366,
0.032226153,
0.013396102,
0.004291202,
-0.018081704,
0.0024860657,
-0.022935852,
-0.01148141,
-0.01976717,
0.0022652694,
0.0034215006,
-0.018014284,
-0.012047727,
-0.019928977,
-0.023529137,
0.0006434275,
-0.017933382,
0.008541953,
-0.011757826,
-0.025322475,
-0.0037417396,
-0.011751085,
0.008804886,
0.003984447,
-0.0030962052,
-0.011805019,
0.0072542555,
-0.021169482,
0.028990055,
-0.006785695,
0.007840798,
-0.011076897,
-0.0053699017,
-0.0058081234,
-0.0049755024,
0.01864802,
0.0030321574,
-0.023852747,
-0.006364328,
-0.0032630665,
0.0073688673,
-0.011501635,
0.0019433448,
0.011622989,
-0.0057710432,
-0.0006434275,
-0.027547292,
-0.013133168,
0.035165608,
-0.0146972835,
0.01234437,
0.006098024,
-0.015668113,
-0.014980442,
-0.029637273,
0.018728923,
0.0036675788,
-0.028882183,
0.0052215806,
0.0069104196,
0.0168412,
-0.013180362,
0.0073688673,
-0.009708297,
-0.01612656,
-0.021034643,
0.031821642,
-0.014441092,
-0.012984848,
0.022827981,
-0.014211868,
-0.016355785,
-0.015101795,
-0.005622722,
0.0037788197,
-0.007746412,
-0.013450037,
-0.015317535,
0.0043788464,
-0.018567119,
0.04481997,
0.0067216475,
-0.019497497,
-0.006964355,
-0.0068227756,
-0.05061798,
-0.0074565117,
0.009526267,
0.0076655094,
-0.010166745,
0.018594086,
0.0059025097,
0.0087105,
0.005990154,
0.01929524,
-0.01727268,
-0.009856618,
0.016193978,
-0.022747079,
0.049323544,
-0.014778186,
-0.025632601,
-0.008225085,
0.029637273,
-0.007584607,
-0.0022922368,
0.03254976,
-0.0017764835,
-0.008663307,
-0.0036709497,
0.020346973,
-0.0044361525,
-0.010591483,
0.017515386,
-0.020009879,
-0.0005098541,
0.0003467851,
0.014629864,
-0.01090835,
-0.022571791,
0.007672251,
-0.0079149585,
0.008750951,
-0.019780654,
0.0011612877,
0.011616247,
-0.015668113,
0.01274214,
0.009256592,
-0.0035057738,
0.036406115,
0.01274214,
-0.0037720778,
0.0016551298,
0.00090341095,
-0.010025165,
-0.023245977,
-0.016517589,
-0.026144983,
-0.012115146,
-0.016167011,
0.003552967,
-0.010449903,
-0.0021641413,
-0.02382578,
-0.03783539,
-0.024135904,
0.0077936053,
-0.024783125,
0.0039507374,
0.018405313,
0.017825512,
-0.009472332,
-0.007389093,
-0.014778186,
0.0109892525,
-0.020738002,
0.022625726,
-0.0076048328,
0.006199152,
0.014737735,
-0.01627488,
-0.007490221,
-0.015573727,
0.01785248,
0.18683079,
0.004459749,
-0.0141444495,
0.006141846,
-0.024459515,
0.007982378,
0.020791937,
0.009667845,
-0.0060103796,
-0.0018877244,
0.0025585408,
0.020454843,
-0.01864802,
0.004351879,
-0.0029158602,
-0.022383017,
-0.035731927,
-0.011292637,
-0.0076318,
-0.012297176,
-0.0180008,
-0.017501902,
-0.0024708963,
-0.013032041,
0.032738537,
0.012971364,
-0.019537948,
0.002494493,
0.021600962,
-0.009768974,
-0.028720379,
-0.027372004,
-0.0031012616,
-0.014521995,
0.0028282157,
-0.0028636106,
0.0097487485,
0.0011756141,
0.009674587,
-0.0033894766,
-0.014346706,
0.031794675,
0.00039439957,
0.015020893,
-0.011474668,
0.03624431,
-0.0021624558,
-0.017178291,
-0.002893949,
0.0123511115,
-0.01483212,
-0.006566584,
0.01292417,
-0.011575796,
-0.038887125,
-0.005214839,
0.006108137,
-0.006064315,
-0.006482311,
0.010921834,
0.006890194,
-0.00003449943,
-0.011144316,
0.01640972,
-0.031147454,
0.036298245,
-0.02559215,
0.0039473665,
-0.006060944,
-0.02199199,
0.009121754,
-0.01666591,
0.0120949205,
0.014589413,
-0.008002603,
-0.02923276,
0.026765235,
0.010537547,
0.026266336,
0.018216541,
0.00027683817,
-0.011528603,
-0.019591883,
-0.019362658,
-0.009249849,
-0.025255056,
-0.01083419,
0.020225618,
-0.0163423,
0.0059699286,
-0.005410353,
0.0195784,
-0.0024894367,
0.010247647,
0.0015523162,
-0.0010542604,
0.0126949465,
0.0060710567,
-0.011009479,
-0.019214338,
-0.014845604,
0.061000466,
0.00943188,
-0.013436553,
-0.0031771075,
-0.011528603,
0.0041091717,
0.041583873,
0.007982378,
-0.014737735,
0.0069373874,
-0.008825112,
-0.000077847566,
-0.014966958,
0.006600294,
0.0018405314,
0.014077031,
-0.027304586,
0.0016188922,
-0.029070957,
0.0016795691,
-0.03999279,
0.011589279,
0.036945462,
-0.008777918,
-0.008514985,
-0.0267113,
0.013045524,
-0.017677192,
-0.02192457,
0.003404646,
-0.0201582,
0.0007799504,
-0.01234437,
0.0029074326,
0.011488152,
0.015573727,
-0.027439423,
0.0072475136,
0.027641678,
-0.0037754488,
0.0037046592,
-0.0012733713,
0.011980308,
-0.013982644,
-0.017838996,
0.008117215,
0.0041226554,
-0.019066017,
-0.006775582,
-0.018621054,
-0.0017646853,
0.021681864,
-0.029151859,
0.022126827,
-0.010773513,
-0.00835318,
-0.01972672,
0.010672385,
0.01249269,
0.012330886,
0.0027237167,
0.03443749,
-0.009984714,
0.0018506441,
0.0146972835,
-0.17151324,
0.016261397,
0.019497497,
-0.030014819,
0.030796876,
0.005713737,
0.019645818,
0.025282023,
-0.030392364,
-0.012162339,
0.006785695,
-0.011562312,
-0.030176623,
-0.008272278,
0.0025956212,
0.0049755024,
-0.0042574927,
0.016733328,
0.03559709,
0.017582804,
0.010362259,
0.0072609973,
0.0050867433,
-0.0029849643,
0.012027501,
-0.003185535,
-0.02574047,
0.02080542,
-0.018189574,
-0.0094925575,
-0.011009479,
0.013672519,
0.018108672,
-0.0135039715,
0.01155557,
0.022976303,
-0.00935772,
-0.021290835,
-0.008798144,
-0.006458714,
0.010409452,
0.020899806,
0.003441726,
0.0035226287,
0.013180362,
0.028154062,
-0.00047235246,
-0.01357139,
0.02321901,
-0.018513184,
0.022801014,
0.0028737234,
0.012263467,
0.025524732,
0.023205526,
-0.013396102,
-0.016571524,
-0.010969027,
0.0012278636,
0.027169747,
-0.014441092,
-0.016288364,
0.018985115,
0.021412188,
0.0048979707,
-0.0033271143,
-0.021412188,
0.000082271916,
-0.011636472,
0.0023225753,
-0.03322395,
0.00006452183,
0.003178793,
-0.019268272,
0.015438889,
0.017083906,
-0.011858954,
0.016045658,
-0.0012169081,
-0.0117106335,
-0.003293405,
0.010652159,
-0.034113877,
-0.015250117,
-0.018890727,
-0.0005317652,
-0.011366798,
-0.007429544,
-0.014939991,
-0.013942193,
0.0201582,
-0.036271278,
0.015182698,
-0.04268954,
0.025322475,
0.0218167,
0.00015558979,
-0.012411788,
-0.014495027,
-0.011467926,
-0.0053867563,
-0.02296282,
-0.023852747,
0.013220813,
0.029637273,
0.0075441557,
0.0032057606,
0.0016761982,
0.048945997,
-0.01256011,
-0.030122688,
-0.015128762,
0.010598225,
-0.0032782357,
0.010962285,
0.040019758,
0.01951098,
0.0014587728,
-0.0009447049,
-0.00020699657,
0.06267245,
-0.0141444495,
-0.00037185644,
0.009088045,
0.0030321574,
-0.017286163,
-0.11725465,
0.013025299,
0.012290434,
0.0010610023,
-0.016153527,
0.007065483,
-0.015304051,
0.01763674,
0.0017967091,
0.02369094,
-0.050402243,
-0.021088578,
-0.007827315,
-0.0022180763,
0.04010066,
-0.006462085,
-0.013214071,
-0.029017022,
0.015870368,
0.033089112,
0.0018557005,
-0.02063013,
-0.009411654,
-0.023610039,
0.0010483613,
-0.0245539,
-0.009849876,
0.015169214,
-0.0069778385,
-0.0043653627,
-0.0004093581,
-0.006998064,
0.022450438,
-0.0126073025,
-0.008986916,
-0.0067991787,
-0.012283692,
-0.012971364,
0.014872571,
-0.025403377,
0.006698051,
0.0029141747,
0.02188412,
-0.00094217673,
0.02742594,
-0.0036001601,
-0.017582804,
0.0020242473,
0.017447967,
-0.030823844,
-0.031632867,
0.0034889192,
-0.025619118,
-0.013861291,
0.016463654,
-0.018526668,
0.0041226554,
0.006310393,
-0.0065834387,
0.011420732,
-0.01335565,
0.015007409,
-0.016045658,
0.03254976,
0.030392364,
-0.037862357,
-0.0070452574,
-0.038806222,
0.0041226554,
-0.022908885,
-0.027776517,
0.026118016,
-0.0117982775,
0.0003097048,
-0.033709366,
0.017798545,
-0.022706628,
0.018270476,
0.008198118,
-0.009694814,
-0.01796035,
-0.019403111,
0.026158467,
-0.01627488,
0.014050064,
-0.010463387,
0.004136139,
-0.005777785,
-0.010052132,
-0.01263427,
0.018027768,
0.04128723,
-0.017110873,
-0.017474934,
0.0360016,
0.02627982,
-0.020441359,
-0.003343969,
0.013807355,
0.002177625,
-0.008407116,
-0.015829917,
-0.05280235,
0.024634805,
0.020225618,
0.001983796,
-0.005245177,
-0.0021641413,
0.026077565,
0.0009236366,
-0.007537414,
0.023583071,
-0.0020006509,
0.03236099,
-0.003991189,
0.00031370777,
-0.035003804,
-0.023353849,
0.0060440893,
0.0146972835,
0.024378613,
0.012378079,
-0.000033814707,
-0.024432547,
0.0021793104,
0.023016755,
-0.0074699954,
-0.008393632,
0.017367065,
0.006323877,
0.0036304987,
0.004567619,
0.012856752,
-0.017421,
0.0054744007,
0.00067629415,
-0.0114544425,
-0.012667979,
-0.0035799346,
0.012067952,
0.028936118,
0.037943263,
-0.020980708,
0.009270076,
-0.004557506,
-0.034895934,
0.018944664,
0.03524651,
0.005845204,
0.030931713,
0.009438622,
-0.012303919,
0.032414924,
-0.003106318,
0.0014587728,
-0.022086376,
-0.0039406247,
-0.0029664242,
-0.010180228,
0.023205526,
-0.010935318,
-0.010031907,
0.021735799,
0.009243107,
0.008697016,
0.009391429,
0.04142207,
-0.023057206,
0.01295788,
0.019200854,
-0.0034686937,
-0.042743474,
-0.017771577,
-0.030392364,
-0.012074694,
0.014198384,
-0.0014655147,
-0.0011385338,
-0.0019214338,
0.024634805,
-0.018917695,
0.015182698,
-0.011852212,
0.020239102,
-0.042500768,
0.019362658,
0.015749015,
-0.0004643465,
0.002411905,
0.01817609,
0.016598491,
0.019160403,
-0.020724518,
0.014090515,
0.02095374,
-0.0008385205,
-0.004564248,
0.015870368,
0.020832388,
-0.0041597355,
0.029529404,
0.005878913,
0.019052533,
0.003067552,
-0.021965021,
-0.028585542,
-0.0072542555,
-0.007314932,
-0.0076789935,
-0.032657634,
-0.0060777985,
0.00011966824,
0.0004736166,
0.01688165,
0.006374441,
0.014980442,
-0.021951538,
0.0038462386,
0.013470262,
0.008899272,
-0.01655804,
0.02350217,
-0.006627261,
0.024176357,
0.026967492,
-0.0201582,
0.038725317,
0.01713784,
0.022774046,
-0.010867899,
0.024958413,
-0.009115012,
0.02947547,
0.005305854,
-0.067580536,
-0.00957346,
0.009984714,
-0.02253134,
0.025282023,
0.025403377,
0.028558575,
0.046357118,
-0.008434083,
-0.011791536,
-0.0053901277,
0.02861251,
0.008083506,
0.032630663,
0.0146972835,
-0.002893949,
-0.02138522,
0.01756932,
0.002624274,
0.026684333,
0.0003659573,
-0.0052316934,
0.015573727,
-0.008272278,
0.024998864,
-0.010537547,
-0.010995995,
0.0014966958,
0.0008102889,
0.0019467159,
0.01756932,
-0.02559215,
0.004783359,
0.011616247,
0.026846139,
-0.011070156,
-0.022733595,
-0.0052687735,
0.00957346,
-0.0009624024,
-0.013234297,
0.03613644,
-0.015304051,
0.0069710966,
-0.0053833853,
0.021479607,
0.0029697951,
0.007948669,
0.01094206,
-0.023663973,
0.0001324146,
-0.022598758,
-0.028369801,
-0.0028282157,
-0.0021675122,
-0.0032007042
] |
DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB-mapping studies have used rad50S or sae2Δ mutants, which are defective in break processing, to accumulate Spo11-linked DSBs, and report large (≥ 50 kb) “DSB-hot” regions that are separated by “DSB-cold” domains of similar size. Substantial recombination occurs in some DSB-cold regions, suggesting that DSB patterns are not normal in rad50S or sae2Δ mutants. We therefore developed a novel | [
-0.047035698,
-0.005104519,
-0.014636324,
-0.03455574,
-0.056820203,
0.037305105,
-0.007742696,
0.010721174,
-0.014932823,
-0.006044559,
0.010963765,
0.008173969,
0.0077359574,
0.01128722,
0.00031650544,
-0.0012474905,
0.020229394,
0.00064564584,
0.0023635775,
-0.0068093943,
-0.023868259,
-0.0150271645,
0.009872106,
-0.0053740647,
0.022250986,
0.0071564345,
0.009730594,
-0.030916875,
-0.023531327,
0.014083755,
0.010997458,
-0.007904423,
-0.018814279,
-0.0013906866,
-0.004663138,
0.005707627,
0.010950288,
-0.0053639566,
0.008093106,
-0.033693194,
0.0036557117,
0.01390855,
-0.0081672305,
0.0020384383,
0.0018110091,
0.015606687,
0.0073653325,
-0.012513652,
-0.0020350688,
0.020876303,
0.00012224312,
0.012068902,
-0.03633474,
0.0026246998,
-0.023329169,
-0.0016467549,
0.017938256,
0.008281787,
0.0024511798,
-0.008868049,
-0.015188892,
0.011159186,
-0.021914054,
0.01772262,
-0.024528645,
-0.006202917,
0.017439598,
-0.0065903887,
-0.008686106,
-0.0054077576,
0.043208152,
0.028544875,
-0.00757423,
-0.008275049,
-0.00044264435,
-0.03301933,
-0.0063949684,
-0.001629066,
0.0068868888,
0.0022186968,
0.020916736,
-0.022601394,
-0.014434164,
0.03183333,
0.0129381865,
0.014515028,
-0.013046005,
0.012837107,
-0.004046553,
0.015337142,
0.012796675,
0.03000042,
0.013147084,
0.010074265,
-0.04323511,
0.0058053373,
0.013868119,
0.018733416,
-0.019380325,
-0.019434234,
-0.022884417,
-0.011961084,
-0.016657915,
-0.015606687,
-0.036496468,
0.016199687,
0.011603936,
-0.014838483,
-0.00014519661,
-0.02450169,
-0.01964987,
0.026159396,
-0.0001537252,
-0.026846737,
0.016765734,
-0.013632267,
0.011772402,
-0.015512346,
-0.025269896,
-0.0036624502,
0.03692774,
0.020930212,
0.012891016,
-0.034879196,
0.023652622,
-0.004282405,
-0.032668922,
0.0074731503,
0.011974561,
-0.009595822,
0.03212983,
0.011132231,
0.0063107354,
0.018625598,
-0.020755008,
0.008625458,
-0.00915781,
-0.01188022,
-0.020458508,
-0.044421107,
0.0076820482,
0.026914123,
-0.01781696,
-0.028841374,
0.014636324,
-0.0027156714,
0.02505426,
0.00017004534,
0.0014622846,
-0.021105416,
0.012163243,
-0.02059328,
0.014312869,
-0.01029664,
0.005222445,
0.028059693,
-0.012365403,
0.013591834,
-0.017143097,
-0.023679577,
0.0035007228,
0.009541913,
0.021860145,
0.0022102736,
-0.004713678,
0.030323874,
-0.015498869,
0.0068161334,
-0.00975081,
-0.0086658895,
-0.015108028,
0.0064522466,
-0.02376044,
0.0037938536,
-0.009831674,
0.005259508,
-0.008692844,
-0.003975797,
-0.020418076,
-0.01500021,
-0.015013687,
-0.02000028,
0.028005783,
0.024892531,
-0.025472054,
-0.010134913,
0.004177956,
0.0053403713,
-0.0018649183,
0.007055355,
0.01994637,
0.014878915,
0.009427356,
-0.012338447,
-0.62318933,
0.007823559,
0.002030015,
-0.031294238,
0.014986733,
0.027021943,
0.0058289226,
0.01411071,
-0.026321122,
0.02464994,
-0.010289902,
-0.0023180917,
0.025485532,
-0.0037803764,
-0.02555292,
-0.023396553,
0.014393733,
-0.0020199069,
0.031348146,
0.020808917,
-0.011988038,
-0.0014176412,
-0.008679367,
0.026941078,
0.006907105,
-0.0064354,
0.011570243,
-0.008059412,
-0.0052089677,
0.014717187,
-0.026536759,
-0.0030256489,
-0.003574848,
0.015633643,
0.044448063,
0.01010122,
0.008524378,
0.02173885,
0.039677106,
0.039030198,
-0.0023281998,
-0.00085917645,
0.021442348,
0.0019710518,
-0.0140298465,
0.010310117,
0.015579733,
0.010572924,
-0.028410101,
-0.010896379,
0.0028234897,
-0.005886201,
-0.006613974,
0.010795299,
0.018490825,
0.018666029,
-0.003935365,
-0.003222754,
0.016415324,
0.016752256,
-0.0053235246,
0.023639144,
-0.0046597687,
-0.030054329,
-0.011691539,
-0.026671533,
-0.026348079,
0.0059872805,
0.027844056,
-0.0002341677,
0.020350689,
0.0024427567,
0.015808847,
0.011947607,
-0.0011354607,
0.026496328,
0.0028740296,
0.017843915,
-0.01242605,
0.017520461,
0.0075270594,
-0.003925257,
-0.03202201,
-0.007587707,
0.0467392,
-0.024056941,
-0.0129381865,
0.020310257,
-0.00925889,
-0.017776528,
-0.0037601604,
0.007533798,
-0.00227766,
-0.02316744,
-0.00792464,
0.025889851,
-0.019676825,
0.0053841723,
-0.015081074,
-0.030108238,
-0.025984192,
-0.004410439,
-0.00304418,
-0.009413878,
0.024245622,
0.004841712,
-0.020660667,
-0.009481265,
0.013322289,
-0.012864062,
-0.002390532,
0.002847075,
-0.017547416,
-0.00658365,
-0.0117656635,
-0.03118642,
0.03153683,
0.012399095,
0.005559377,
-0.003975797,
0.008086367,
-0.0057312124,
0.0006241664,
-0.04531061,
0.0058289226,
0.018679507,
0.013935505,
0.0043228366,
0.009986662,
-0.014380256,
-0.00036430766,
0.0041914335,
0.008719799,
-0.022480099,
0.00006770226,
-0.025620304,
0.004663138,
-0.013827687,
-0.00084948965,
-0.037412923,
-0.032372423,
0.0017604694,
-0.010060788,
0.015674073,
-0.015229324,
-0.005259508,
-0.039542332,
-0.00032977213,
0.01975769,
0.0029683704,
0.024313008,
0.01925903,
-0.015566256,
-0.005219076,
-0.00955539,
-0.007594446,
-0.006303997,
-0.014205051,
-0.00059047324,
-0.0065668034,
0.0008301161,
-0.008355912,
-0.002030015,
-0.0088343555,
-0.022183599,
-0.031806376,
0.028005783,
-0.011327652,
0.00036662407,
-0.022062303,
0.0032648705,
-0.0104246745,
-0.024191713,
0.0030307027,
-0.00930606,
0.04326206,
-0.0040869843,
0.012055425,
0.006074883,
-0.0046665072,
-0.014326346,
-0.025728123,
-0.016577052,
-0.021172803,
0.043450743,
0.011280482,
0.024434304,
-0.01955553,
0.023342645,
0.0054919906,
-0.010195561,
0.0019828444,
0.0137603,
0.016738778,
0.025957236,
0.004589013,
0.031294238,
0.024838623,
-0.0012533868,
0.022709213,
0.024946442,
-0.0067251613,
0.014730665,
-0.0135244485,
0.031860285,
-0.032048967,
0.007655094,
-0.01975769,
0.00070587243,
-0.011846527,
-0.0017318302,
-0.0022557594,
-0.018989485,
0.0068093943,
-0.0022793445,
0.0022153275,
-0.006772332,
0.014124187,
0.0073585934,
0.005906417,
-0.02376044,
-0.00831548,
0.01341663,
-0.021415394,
-0.020364167,
0.001289607,
0.008369389,
0.00010723912,
0.011920652,
-0.0015077704,
0.0062837806,
0.013551403,
-0.022790076,
0.0035782172,
0.005219076,
0.0044744564,
0.0024040095,
-0.004791172,
0.02470385,
-0.002297876,
-0.009959708,
0.009562128,
-0.0006995549,
-0.015256278,
0.02529685,
0.0025354128,
0.021644508,
0.021442348,
-0.004316098,
0.026294168,
-0.026321122,
0.0041813254,
-0.030189103,
0.007345116,
0.0022254356,
-0.013329027,
0.009777765,
0.036523424,
0.030108238,
0.0019794751,
-0.0003085033,
0.0038208081,
-0.0007222979,
-0.027844056,
0.019029915,
0.018531257,
0.014124187,
0.0076348777,
0.0110109355,
0.008490685,
0.0048012803,
0.019784644,
-0.030862967,
-0.03372015,
-0.0048248656,
-0.014218528,
0.006128792,
0.045580152,
0.011940868,
-0.0060917297,
-0.017008325,
-0.030054329,
0.026024623,
0.033477556,
-0.008450253,
0.000247645,
-0.010983981,
0.0009990032,
0.0011177717,
0.03064733,
0.001705718,
0.01979812,
0.013423368,
0.03326192,
-0.014744142,
-0.017547416,
0.012803414,
-0.025620304,
0.033181056,
0.0008515955,
0.011192879,
0.023544803,
-0.018625598,
-0.02579551,
0.05876093,
0.004113939,
0.0013654167,
-0.0047305245,
-0.016792689,
-0.02005419,
-0.0012533868,
-0.004370007,
-0.02677935,
0.002959947,
-0.023746964,
-0.011408515,
-0.0014488073,
-0.0133559825,
0.014326346,
0.016469233,
-0.02346394,
-0.017453074,
0.00022532324,
-0.00006643877,
0.025108168,
0.03544524,
-0.015310188,
0.013012311,
0.0064084455,
0.012392357,
-0.00856481,
-0.032048967,
0.025701169,
-0.016186211,
0.00025312012,
-0.0025859526,
0.011691539,
0.024151282,
-0.0009038199,
0.025027305,
0.029542193,
-0.029865647,
-0.009528436,
-0.0013578357,
-0.019353371,
0.022763122,
0.012634948,
0.04401679,
0.028490964,
-0.0031772682,
0.012028471,
0.025822464,
0.027237577,
-0.021684939,
-0.011152447,
0.032399375,
0.0033137256,
0.03366624,
0.02475776,
-0.01544496,
0.015040642,
-0.0050371327,
-0.01703528,
0.013214471,
0.01964987,
0.0026162765,
0.013329027,
0.023922168,
0.0021462564,
-0.009124117,
0.0041274163,
0.0024242252,
-0.027062373,
-0.024056941,
0.02173885,
-0.018126938,
-0.023504373,
-0.020323735,
0.0067992867,
-0.0051011494,
0.0019390433,
-0.021806234,
-0.0080796275,
-0.024528645,
-0.013207732,
-0.015660597,
0.033989694,
0.0004333787,
0.0021361485,
-0.0106740035,
-0.0076348777,
-0.021051507,
-0.017736098,
-0.019690303,
-0.01094355,
-0.0245556,
-0.031806376,
-0.022763122,
0.026563715,
0.017264392,
0.021348007,
-0.011590458,
-0.020364167,
0.002954893,
-0.024029987,
-0.015687551,
0.006297258,
-0.02014853,
-0.0026853476,
0.022655305,
0.008868049,
-0.01994637,
-0.023490895,
0.024784714,
0.005286462,
0.002430964,
-0.011165924,
-0.0033608961,
0.0035377855,
0.031105557,
0.016105346,
0.03169856,
-0.005539161,
-0.004285774,
-0.0017739467,
-0.027331918,
-0.036523424,
-0.031752467,
-0.00475411,
-0.01044489,
-0.017911302,
-0.007944855,
0.02529685,
-0.00841656,
0.016509665,
-0.008585026,
0.009488003,
-0.0016492818,
0.036038242,
0.0098384125,
0.020067666,
0.012203675,
-0.017399166,
0.0038309162,
-0.0021951117,
-0.022695735,
0.016913984,
-0.00289593,
-0.02083587,
0.014205051,
-0.000090497815,
-0.05331611,
-0.020418076,
0.00009476211,
0.0017604694,
0.04172565,
-0.004524996,
-0.025566395,
-0.011812834,
0.006728531,
0.0034636604,
0.017170051,
-0.013868119,
0.0029178306,
-0.019056872,
0.008679367,
-0.0055054678,
-0.007122741,
-0.0055357916,
-0.03396274,
-0.006752116,
0.017210484,
-0.008618719,
0.009548651,
-0.010727913,
0.0011219834,
-0.01500021,
-0.017857393,
-0.015876234,
-0.048140835,
-0.001450492,
0.006516264,
0.04609229,
0.03353147,
0.028005783,
-0.0047170473,
0.018854711,
0.019083826,
0.01886819,
-0.0140298465,
-0.0057143657,
0.0108424695,
-0.023787396,
0.013409891,
0.013531187,
-0.008679367,
-0.013430107,
-0.02079544,
0.021294098,
0.026914123,
-0.015795369,
-0.030755147,
0.019366847,
-0.04905729,
-0.005219076,
-0.021846667,
0.007560753,
0.014151142,
-0.047790427,
0.011523073,
0.017749574,
0.009764288,
0.008571548,
0.007089048,
0.045121927,
0.0056469794,
0.019932894,
-0.005808707,
0.0143533,
-0.009326276,
-0.008760231,
-0.007405764,
0.0015136667,
0.028329238,
0.0057446896,
0.0047743255,
-0.0074664117,
-0.0041274163,
0.013039266,
0.0074798893,
-0.025808986,
-0.00067302154,
0.00034998805,
-0.008854572,
-0.002959947,
-0.015647119,
-0.0108424695,
-0.050674565,
0.0119341295,
-0.014595891,
-0.005822184,
0.020862825,
0.013329027,
-0.016644439,
0.017197005,
0.00037925903,
0.014312869,
-0.025930282,
0.016698347,
0.02198144,
0.010498799,
-0.032615013,
-0.013558141,
-0.017102666,
0.004413808,
0.024973396,
0.028194465,
-0.016711824,
-0.020970644,
0.012358664,
-0.021900576,
-0.013639005,
-0.028895283,
0.010316856,
-0.015229324,
0.016051438,
0.0018800802,
0.0029565778,
-0.0065769115,
0.015269755,
0.001036908,
0.019744212,
0.003460291,
-0.008227878,
-0.018005643,
0.0069879685,
-0.004905729,
0.017250916,
-0.022237508,
-0.015067596,
-0.0028538136,
-0.017749574,
-0.002183319,
0.0036860355,
0.0071968664,
0.0529657,
-0.012756243,
-0.007318162,
0.00065870193,
0.024366919,
-0.032911513,
-0.025674215,
0.00081326946,
0.04118656,
-0.019932894,
-0.01312013,
-0.0064286613,
0.015242801,
-0.009656469,
0.020391122,
-0.010067526,
0.007843776,
-0.021994917,
0.0051415814,
0.026792828,
0.015687551,
-0.006118684,
-0.0071025253,
-0.027507124,
0.0016231696,
-0.0065802806,
-0.043046426,
0.029515238,
-0.0434777,
-0.0069475365,
0.000037562648,
0.0040566605,
0.021509735,
0.011172663,
-0.00051171536,
0.00259943,
0.020687621,
-0.019380325,
0.015768414,
0.004430655,
0.010310117,
-0.03040474,
0.013382937,
0.0020199069,
-0.009993401,
-0.000319243,
-0.005030394,
0.012021732,
0.0058390307,
-0.0044744564,
0.009124117,
0.0021226713,
-0.01544496,
0.031860285,
-0.010566186,
0.008969128,
0.0017419382,
-0.00618944,
0.020957166,
-0.009723856,
0.0020603389,
0.00608836,
-0.007190128,
-0.030620376,
-0.017897826,
-0.0070014456,
-0.007985287,
-0.019339893,
-0.0004586486,
0.010775084,
-0.0026567085,
0.002193427,
0.0039421036,
-0.009535174,
0.0005525684,
-0.024582554,
0.004376746,
0.0116848,
-0.0084974235,
0.022264462,
0.0070620934,
-0.0218871,
0.018383007,
-0.021118894,
0.007291207,
0.0004346422,
-0.01955553,
-0.032588057,
0.003931996,
-0.012203675,
0.029569147,
0.023490895,
-0.014164619,
-0.0101753445,
-0.0005188752,
-0.03746683,
-0.019205121,
0.00569415,
-0.0041712173,
0.029811738,
0.033747103,
-0.008692844,
0.023693055,
0.006529741,
0.0254451,
-0.010316856,
-0.00688015,
0.019461188,
0.0037938536,
0.0029885864,
0.0028723448,
-0.03900324,
-0.004481195,
0.01950162,
-0.0022591287,
-0.005178644,
0.025782032,
-0.0091712875,
0.01074139,
-0.010390981,
0.0048484504,
0.033423647,
0.017291347,
-0.006954275,
-0.039731015,
-0.019542053,
0.0062669343,
0.002094032,
-0.03331583,
-0.0001357204,
0.005657087,
0.012695596,
0.0022742907,
-0.015525823,
-0.025121646,
0.0032800324,
-0.045661017,
0.034690514,
0.028005783,
-0.0057547977,
0.023329169,
0.011886959,
-0.002446126,
-0.0053808033,
-0.016253596,
-0.0029616319,
-0.005276354,
-0.018827757,
-0.00082211394,
-0.0016737094,
-0.012486698,
-0.0049832235,
-0.015660597,
0.009723856,
-0.014393733,
-0.024542123,
-0.026267214,
0.031294238,
0.017601324,
-0.0022254356,
-0.012048686,
0.020391122,
-0.019959848,
-0.0069273207,
0.018531257,
0.01588971,
-0.014811528,
0.03490615,
0.005283093,
-0.037952013,
-0.013450323,
-0.009656469,
0.0028352824,
-0.025418146,
0.03366624,
0.19849335,
0.006458985,
0.0004032654,
0.032210693,
-0.0016324352,
-0.023854781,
0.003322149,
-0.0055189454,
-0.029542193,
-0.007709003,
0.01178588,
0.01712962,
-0.015498869,
-0.0023635775,
0.04331597,
0.013329027,
-0.014946301,
-0.0024191714,
-0.02357176,
0.00020005334,
0.017385688,
0.005529053,
-0.0070823096,
0.0033474187,
0.018046075,
0.0026870323,
-0.03644256,
-0.018099984,
-0.0040364447,
0.030269966,
-0.019690303,
0.008854572,
-0.0059300023,
-0.0020283302,
0.008874787,
0.012068902,
-0.011550027,
-0.018396484,
0.00093835546,
0.008699583,
-0.013780517,
0.01703528,
0.0042049107,
-0.0055762236,
-0.02005419,
-0.009730594,
-0.0073383776,
-0.02124019,
-0.011907175,
0.010161867,
-0.018598644,
0.0041274163,
0.024447782,
0.028275328,
-0.0005572012,
-0.021873621,
0.024029987,
0.0015094551,
-0.0035175695,
0.009400401,
-0.010599879,
0.013005573,
-0.048194744,
0.015835801,
-0.015795369,
0.021954486,
-0.015835801,
0.019393802,
0.03377406,
-0.0014386994,
-0.004706939,
-0.023059621,
-0.0062298714,
-0.011873482,
-0.012075641,
-0.015067596,
0.039030198,
0.014676755,
0.03172551,
0.014636324,
-0.0076753097,
-0.020674145,
-0.010343811,
0.008140275,
0.018585166,
-0.015714506,
0.031213375,
0.0074933665,
-0.015916664,
-0.00036409707,
-0.0016273813,
-0.00028386517,
-0.009386924,
0.003510831,
-0.01272255,
-0.016011005,
-0.028356193,
0.023356123,
-0.011159186,
-0.0068464573,
-0.025984192,
0.05897657,
0.008982605,
-0.00026828205,
-0.0058592465,
-0.009710379,
0.015256278,
0.008456992,
-0.0052493997,
-0.0018800802,
0.022345327,
-0.024515169,
0.014474596,
-0.00048855133,
0.0033154103,
0.032938465,
0.02192753,
-0.039919697,
0.024178237,
-0.006357906,
-0.009521697,
-0.02500035,
-0.003766899,
0.016752256,
-0.027897965,
0.007237298,
-0.012149766,
0.0097575495,
-0.015094551,
-0.02435344,
0.008699583,
0.003163791,
0.023989554,
0.005441451,
0.0047035697,
-0.012203675,
0.014811528,
-0.015108028,
-0.01911078,
-0.0016998217,
0.011496118,
-0.00024385449,
-0.0015406213,
0.016819643,
-0.0121025955,
-0.021698417,
0.017911302,
0.014164619,
-0.019434234,
0.0025859526,
-0.009076946,
-0.003723098,
-0.010209038,
-0.010727913,
-0.011799357,
-0.021806234,
-0.018989485,
-0.04455588,
-0.0043194676,
0.017655233,
-0.02638851,
0.029030057,
0.015930142,
0.0007420926,
-0.0112602655,
0.0011346183,
-0.17067625,
0.01212955,
0.013726607,
-0.037493788,
0.015215847,
0.016213166,
0.01940728,
0.014663278,
0.007075571,
0.004440763,
0.030485602,
0.019878985,
-0.04248038,
-0.014043324,
-0.008558071,
0.009292583,
-0.009373447,
0.019420758,
0.018153893,
0.014757619,
0.0039960127,
-0.03757465,
-0.0032042228,
-0.0066914684,
0.0066476674,
0.012850584,
-0.00027796885,
0.0044744564,
0.010748129,
-0.0089960825,
-0.010808777,
0.006954275,
0.018639075,
-0.021213235,
0.00970364,
-0.0140298465,
-0.015727984,
-0.00069239514,
-0.0042386036,
-0.0009400401,
0.03407056,
0.010957027,
0.0069744913,
-0.014178096,
-0.004329575,
0.020620234,
0.017776528,
-0.013510971,
0.016644439,
-0.0036860355,
0.009858629,
-0.00846373,
0.039434515,
0.0319681,
0.02411085,
-0.0033827967,
-0.02400303,
0.034178376,
-0.009609299,
-0.00787073,
-0.006627451,
-0.039973605,
0.046766154,
-0.004427286,
-0.002382109,
-0.016860075,
-0.008854572,
-0.0026887169,
-0.036900785,
0.012951664,
-0.004821496,
0.02881442,
0.011024413,
-0.0026263844,
-0.009137594,
0.0153640965,
-0.008322219,
0.006317474,
-0.020930212,
-0.033585377,
-0.0131875165,
0.039030198,
-0.018356051,
-0.00985189,
-0.004838343,
-0.007048616,
-0.008254833,
0.004484564,
-0.005525684,
-0.015674073,
0.02372001,
-0.017749574,
0.022641826,
-0.011206357,
0.026496328,
0.013686175,
-0.0047305245,
0.0031469443,
-0.0025286742,
0.0014420687,
-0.010903117,
-0.015013687,
-0.031914193,
0.008632196,
0.02579551,
0.0006018447,
-0.00045317347,
0.016860075,
0.03746683,
-0.0056301327,
-0.014784574,
-0.025027305,
0.027331918,
0.010572924,
-0.0055324226,
0.036065195,
-0.01035055,
0.012675379,
0.016415324,
-0.02124019,
0.076173574,
-0.0061254227,
0.0071699116,
-0.008706321,
0.012520391,
-0.024420828,
-0.1141795,
-0.021253668,
0.005401019,
0.031321194,
-0.008396344,
-0.006644298,
0.0072979457,
0.038787603,
-0.010795299,
0.017089188,
-0.011415254,
-0.029488284,
0.00063722255,
-0.003386166,
-0.01148264,
0.016011005,
-0.013254902,
-0.012709073,
0.016011005,
0.027978828,
0.0043363143,
-0.00564361,
0.002678609,
-0.012109334,
0.015161937,
0.007911162,
-0.02173885,
0.012338447,
-0.0067352694,
0.033342786,
-0.002024961,
-0.02000028,
0.015512346,
-0.001205374,
-0.02292485,
-0.02376044,
-0.0017284609,
-0.037412923,
0.041267425,
-0.010620095,
0.005825553,
0.011523073,
0.0069138436,
0.017493507,
0.009407139,
-0.0045620585,
0.0024730805,
0.0287066,
0.015040642,
-0.01796521,
-0.024447782,
-0.0053100474,
-0.026954556,
-0.0053976495,
0.010835731,
-0.021401918,
0.022237508,
0.01836953,
-0.031375103,
-0.0037332058,
-0.0011447263,
-0.0005411969,
-0.0062399795,
0.0044037006,
0.016752256,
-0.024622986,
-0.020108098,
-0.03415142,
0.039245833,
-0.02787101,
-0.0060681445,
0.003237916,
-0.02659067,
0.0039960127,
-0.005707627,
-0.021132372,
-0.020781962,
-0.022372281,
0.0056503485,
-0.022358803,
-0.014959779,
-0.019164689,
0.012675379,
-0.037143376,
0.04242647,
0.007655094,
-0.004430655,
-0.002931308,
0.0020957168,
-0.01624012,
-0.0038107003,
0.055175975,
-0.023302212,
-0.023383077,
-0.02074153,
0.030458648,
-0.0054246043,
-0.003851132,
0.016011005,
0.015525823,
-0.043585517,
-0.015134983,
-0.057790566,
0.024286054,
0.013463801,
-0.0010916595,
-0.00048349734,
-0.015916664,
0.021024553,
0.0012727604,
-0.0044171778,
0.02242619,
-0.019434234,
0.011523073,
-0.016590528,
-0.03053951,
-0.039542332,
-0.04326206,
0.020862825,
0.007917901,
0.017506983,
0.023531327,
-0.023234827,
-0.015310188,
0.033585377,
0.01911078,
0.0009004506,
-0.0021108787,
-0.012385618,
0.023908691,
-0.0051820134,
0.0051011494,
-0.0021159325,
-0.033154104,
-0.028922237,
0.0032682398,
-0.000043722182,
-0.017439598,
-0.0052089677,
0.014461119,
0.02940742,
0.028005783,
-0.026226783,
-0.03579565,
-0.0047170473,
0.009083685,
-0.014919346,
0.02361219,
-0.036846876,
0.008531117,
0.003490615,
-0.028868329,
0.022183599,
0.009514958,
-0.0016720247,
-0.030162148,
-0.03407056,
0.003965689,
-0.003588325,
0.015539302,
0.005343741,
-0.024488214,
0.02568769,
0.011105277,
0.036415603,
0.0034333365,
0.010465106,
-0.0033625807,
-0.0033996433,
-0.013544664,
-0.009973185,
-0.03563392,
-0.030350829,
0.013686175,
0.02203535,
0.004936053,
-0.017763052,
-0.007291207,
-0.03431315,
-0.0065903887,
-0.0044576097,
-0.0008768654,
0.013308812,
0.0013873173,
-0.0038881947,
0.018679507,
0.019299462,
0.0030610268,
0.0043329448,
0.020108098,
-0.009845152,
0.004117308,
0.0071362187,
0.019838553,
0.020970644,
0.0018177478,
0.0018969268,
0.02316744,
-0.010983981,
-0.0021900577,
0.021064986,
0.0020923472,
-0.012035209,
-0.016738778,
0.0038477627,
-0.010559447,
-0.0008187446,
0.037359014,
-0.010114697,
-0.025269896,
0.0033726888,
-0.00014982943,
0.0019221967,
0.0089960825,
0.0034080667,
0.02203535,
-0.004514888,
0.0022658673,
0.007190128,
-0.030081283,
0.0005883674,
-0.0003710463,
0.021941008,
0.0069677527,
-0.01584928,
-0.00950822,
0.040216196,
-0.0020030604,
0.029057011,
-0.018288666,
-0.017776528,
-0.015350619,
0.036954697,
-0.018356051,
-0.020081144,
-0.015310188,
0.0059872805,
0.007863992,
0.015040642,
0.00589294,
-0.022183599,
0.08593112,
0.034879196,
0.0012070587,
0.0032160154,
-0.04035097,
0.013504232,
0.005242661,
0.013409891,
0.011671322,
-0.04590361,
0.03981188,
-0.021294098,
0.018787324,
-0.0044373935,
-0.0173183,
0.023706531,
-0.011779141,
0.012439528,
-0.01520237,
-0.032102875,
0.023881735,
-0.030458648,
0.021590598,
0.044043742,
-0.013241425,
0.002173211,
0.014380256,
-0.0055223145,
0.012082379,
-0.009070208,
0.004811388,
-0.015283233,
-0.03094383,
-0.01871994,
0.02559335,
-0.000072598305,
0.0032497086,
-0.0059738033,
0.026105488,
0.016442278,
-0.0124327885,
-0.01718353,
-0.011866743,
-0.02266878,
0.010815515,
-0.0042756665,
-0.008571548,
-0.00037125687,
-0.0034737682
] |
CONTEXT The mechanisms that drive progression from fatty liver to steatohepatitis and cirrhosis are unknown. In animal models, obese mice with fatty livers are vulnerable to liver adenosine triphosphate (ATP) depletion and necrosis, suggesting that altered hepatic energy homeostasis may be involved. OBJECTIVE To determine if patients with fatty liver disease exhibit impaired recovery from hepatic ATP depletion. DESIGN Laboratory analysis of liver ATP stores monitored by nuclear magnetic resonance spectroscopy before and after transient hepatic ATP depletion was induced by fructose injection. The study was conducted between July 15 and August 30, 1998 | [
-0.005771364,
-0.016062351,
0.0133786155,
-0.037064906,
-0.03791943,
0.012690992,
-0.032845702,
0.025021482,
-0.027478235,
-0.011315745,
0.0053674686,
0.016436204,
0.0041791485,
0.016396148,
0.0050503607,
0.001358557,
0.032952517,
-0.0147939185,
0.004399455,
-0.0013109909,
-0.03260537,
0.014046212,
0.00026808135,
-0.011449264,
0.021443171,
0.010875132,
0.012370546,
-0.041364223,
-0.006996402,
-0.019039826,
0.01368571,
-0.022671547,
-0.01578196,
0.00027413145,
0.010354408,
-0.017330782,
-0.015888775,
-0.0016439542,
0.011135494,
-0.013305181,
-0.00044269933,
0.0044461866,
-0.008959133,
0.0075171264,
-0.0025101595,
-0.00055827684,
0.005450918,
-0.009039245,
0.0036083541,
0.026623713,
0.005734646,
0.015461514,
-0.00795774,
-0.0031577272,
-0.00037865186,
-0.014486824,
-0.013545515,
0.008011147,
-0.006382214,
-0.008538548,
-0.010661501,
0.00820475,
-0.020628704,
0.0061685834,
-0.0013485431,
0.034528043,
-0.0016990307,
0.018639268,
-0.002106264,
0.011409209,
0.04253919,
0.028946945,
-0.007390283,
0.011075411,
0.013612274,
-0.0033763647,
-0.0019260133,
-0.016716594,
-0.0017674593,
0.020802278,
0.030228728,
-0.010187509,
-0.020628704,
0.04854755,
0.010427843,
0.000489431,
0.006672618,
0.0349019,
0.02017474,
0.010000582,
0.006675956,
0.036717758,
0.02771857,
0.02261814,
-0.008738826,
-0.005263991,
-0.008478465,
0.012657613,
-0.015955536,
-0.027318012,
-0.020975854,
0.006208639,
-0.033059333,
-0.0057446603,
-0.013031466,
0.020521889,
0.0011082087,
0.0035783125,
0.0017724663,
-0.023646235,
-0.006889587,
0.031483807,
0.0046164235,
-0.015848719,
-0.0070765135,
0.009106004,
-0.0026803964,
0.006822827,
-0.015902128,
-0.02276501,
0.013225068,
0.0055477195,
0.036610942,
-0.0013827573,
-0.009519913,
-0.010808373,
-0.011889878,
-0.00090125407,
-0.0066392384,
-0.010881809,
0.015488218,
-0.005617817,
0.004379427,
-0.0049702493,
-0.024353888,
0.019146642,
-0.027104381,
-0.020935798,
-0.03065599,
-0.027958903,
0.0028255985,
0.004900152,
-0.021483226,
-0.007590562,
-0.008318241,
0.015020901,
0.016676538,
0.010147453,
-0.012423954,
0.0005599458,
-0.013538838,
-0.0038520265,
0.009566645,
0.0039254623,
0.0064957053,
0.018946363,
-0.010788345,
-0.0038119708,
-0.014860678,
-0.028733315,
0.006832841,
-0.005057037,
-0.002728797,
-0.0040089116,
-0.0081646945,
0.008999188,
0.0071032173,
-0.0011082087,
0.008178046,
-0.016222574,
0.0050904164,
0.0018892955,
-0.0016247608,
0.025982821,
0.00014342874,
0.014099619,
-0.009192792,
0.020588648,
-0.016743297,
-0.041818187,
-0.019440385,
0.019079883,
0.03199118,
-0.00086870877,
-0.005327413,
0.004990277,
0.025755838,
-0.0023916613,
0.0042292182,
-0.022738306,
0.010568039,
0.015368051,
-0.032231517,
-0.0013593915,
-0.65456414,
-0.019013122,
0.011122143,
-0.00058664964,
0.0015229525,
0.017223967,
0.015020901,
0.0139661,
-0.020241499,
0.020802278,
-0.016382797,
0.0035082148,
0.0004948552,
-0.012897947,
-0.008879022,
-0.017277375,
-0.014353305,
-0.0016940238,
0.006188611,
-0.013398644,
-0.005000291,
0.018198656,
-0.008465112,
0.00858528,
0.03204459,
0.026690472,
0.015514921,
0.002580257,
-0.009546617,
0.026637064,
0.0051738657,
0.04414142,
0.0062920884,
0.0071499487,
0.05992338,
0.001996111,
-0.00063087785,
0.0061084996,
-0.004596396,
0.030388951,
-0.0122103235,
-0.01809184,
0.03653083,
0.008351621,
-0.011422561,
0.012924651,
0.011182226,
-0.007750785,
-0.016609779,
0.0036183682,
0.020735519,
0.008258157,
-0.024954723,
0.015101013,
0.013625626,
-0.013605598,
0.011676247,
-0.0418983,
0.011269013,
0.023819812,
0.01683676,
0.0149941975,
-0.022511324,
-0.020308258,
-0.017437598,
0.0064556496,
-0.011415885,
0.008478465,
0.0013777504,
0.0008274013,
0.025341928,
0.025568912,
0.0057446603,
0.008405029,
0.025462097,
-0.00016961101,
0.007737433,
0.014112971,
-0.016810058,
0.0023849853,
0.0041624587,
0.015274587,
0.0020662083,
-0.013765821,
0.030228728,
0.0015588357,
-0.018879604,
0.0014144682,
0.0065824925,
0.010301,
0.008985837,
0.008959133,
-0.008625335,
-0.0025936088,
-0.029347502,
0.03415419,
-0.030976435,
-0.012377222,
-0.0047599566,
-0.0029808143,
-0.011415885,
-0.0003461066,
-0.0036050163,
0.0017140517,
0.03017532,
0.006208639,
-0.039708585,
0.0078576,
0.05228609,
-0.02953443,
0.019894348,
-0.019053178,
-0.005070389,
-0.009793627,
0.00030521635,
-0.01717056,
0.019106586,
-0.0034648213,
-0.0082114255,
-0.033753633,
0.028172534,
0.012911299,
0.02213747,
-0.0027771976,
-0.003488187,
0.018545806,
-0.0036684377,
-0.02339255,
-0.021216188,
0.02458087,
0.008598631,
0.01578196,
0.026316619,
-0.0041657966,
0.032845702,
-0.013472079,
0.011876525,
0.00604174,
0.007864276,
-0.052900273,
-0.032498553,
-0.012263731,
-0.011629515,
-0.0006166914,
-0.014513528,
-0.016569722,
-0.0008995851,
0.008051203,
0.012510741,
0.02179032,
-0.016369443,
-0.00056787353,
-0.018065138,
0.028733315,
0.0034581453,
-0.00012089739,
-0.002553553,
-0.024313832,
-0.009907119,
0.012390574,
-0.0076439697,
0.019814238,
0.005020319,
0.010501279,
-0.011863174,
-0.016516315,
0.0164095,
-0.014032859,
-0.01155608,
-0.0016514646,
-0.0116028115,
-0.023018695,
-0.009005865,
0.02122954,
-0.017704636,
0.018131897,
0.0020812294,
-0.015408106,
-0.0064189318,
-0.001510435,
0.02046848,
-0.005454256,
0.00694967,
0.02248462,
0.018131897,
0.032952517,
0.024968075,
0.016516315,
-0.0014995866,
0.039842106,
-0.0045162844,
0.022925233,
-0.0014803932,
0.0025134974,
-0.0051371483,
0.0037318594,
-0.0061051617,
-0.021536633,
-0.00998723,
0.020308258,
0.045770355,
-0.035355862,
0.029641245,
-0.03372693,
0.029721357,
-0.0096067,
-0.012924651,
-0.0020478496,
0.016876817,
-0.009499885,
-0.010007258,
-0.003968856,
0.0064523113,
-0.0041925004,
-0.0044929185,
0.016796704,
0.008758854,
-0.015287939,
0.0004397786,
-0.022431212,
-0.0037285215,
-0.0076372935,
0.020989206,
0.006692646,
0.0020662083,
0.008011147,
0.004212528,
0.036984798,
-0.007123245,
0.009373042,
-0.0006033395,
-0.011629515,
-0.011949961,
0.0044628764,
0.013712414,
0.016035646,
-0.0107950205,
-0.016583074,
0.024287127,
0.018051784,
0.015488218,
0.011929933,
0.018105192,
-0.022404509,
-0.0007497933,
-0.010694882,
0.01774469,
0.022658195,
-0.029427614,
-0.0024434,
-0.009960527,
0.03078951,
-0.042886343,
-0.01452688,
0.00071766524,
-0.009840359,
0.0035682984,
-0.0050970926,
0.028973648,
0.0076639974,
0.014687103,
0.019921053,
0.028119126,
-0.018065138,
0.00638889,
-0.0017858183,
0.002438393,
0.021349708,
-0.0020762223,
0.01725067,
-0.020067923,
-0.006258709,
-0.004279288,
-0.016516315,
0.03821317,
-0.0041891625,
0.013979452,
-0.0107950205,
0.037331946,
-0.01494079,
-0.0020979191,
-0.027745273,
0.018892955,
0.017571116,
-0.0016848444,
-0.0100539895,
-0.017584467,
0.007864276,
-0.009473181,
0.0021613408,
0.0017924942,
0.004149107,
0.008718799,
0.003341316,
-0.009973878,
-0.019720774,
0.029694652,
-0.028733315,
0.025395336,
-0.016182518,
0.001515442,
0.00085118436,
-0.00320279,
0.0058147577,
0.03866714,
0.021323003,
-0.00028644025,
0.002885682,
0.019533847,
-0.0014737173,
0.0039621796,
-0.0052372874,
0.009973878,
0.0076506454,
0.007403635,
-0.0006776095,
-0.023552774,
0.03345989,
0.03380704,
-0.011495996,
-0.0029474346,
-0.013345236,
-0.0044428487,
-0.01738419,
0.025568912,
0.02255138,
0.00935969,
0.013405319,
0.031163363,
0.027037622,
0.03017532,
-0.014967494,
0.038106356,
0.0043126675,
0.011642867,
-0.000198714,
0.0075304783,
-0.0045062704,
-0.0019093234,
0.009840359,
-0.008825614,
-0.021723561,
-0.005437566,
-0.0011849821,
0.0044228206,
-0.00041390926,
0.016729945,
0.028653203,
0.004699873,
-0.0026153058,
-0.0028372812,
0.034314413,
0.0022013965,
-0.014580288,
-0.026984215,
0.0079644155,
-0.008304889,
0.0085251955,
0.0006050085,
-0.022297693,
-0.00039680212,
0.00757721,
0.01984094,
0.007917684,
0.017237319,
0.005454256,
0.018358879,
0.010561362,
0.018652622,
0.003481511,
-0.010634798,
0.017544413,
-0.0035349187,
-0.013078198,
0.02507489,
-0.008358297,
-0.00062837434,
-0.0022064035,
-0.013078198,
-0.019360272,
0.0008440912,
-0.012383899,
0.00420919,
-0.008311565,
0.008638687,
-0.0134453755,
0.028546387,
-0.0021029261,
-0.0024784487,
-0.014673751,
-0.026196452,
-0.036771167,
-0.024060145,
0.0017741353,
0.0075104507,
-0.009246199,
-0.01058139,
0.021723561,
-0.008932429,
0.006612534,
-0.0015538287,
-0.024727741,
0.002279839,
0.00858528,
-0.030575879,
-0.010855105,
-0.0062286668,
-0.031457104,
0.0043193437,
-0.0072233845,
-0.0013401982,
-0.019921053,
0.0072167083,
-0.008565252,
0.017637875,
-0.0059749805,
0.024834557,
0.0034648213,
-0.010601418,
-0.01295803,
0.020428425,
-0.007123245,
-0.010100721,
0.0025218425,
0.018385584,
-0.021590041,
-0.0031376993,
-0.009853711,
-0.015808664,
-0.018051784,
-0.0026436786,
-0.019814238,
-0.0000917944,
-0.021069316,
0.020895742,
0.01962731,
0.0070698373,
-0.011616163,
0.016316036,
0.033780336,
-0.01508766,
0.009179439,
0.0005340765,
0.0090192165,
-0.027478235,
-0.025996173,
0.023232326,
0.013078198,
-0.009666785,
0.0043260194,
-0.0022431212,
-0.02375305,
-0.03869384,
-0.0038386746,
-0.00548096,
0.02779868,
-0.013792525,
-0.04168467,
-0.04665158,
0.009326311,
-0.025368633,
0.007256764,
0.00820475,
-0.014112971,
-0.01703704,
0.008785558,
0.0028389504,
-0.007830896,
0.04838733,
-0.034741674,
-0.009433126,
0.010387788,
-0.008251482,
0.000102069105,
-0.004092361,
-0.0012809491,
-0.03602346,
0.002284846,
-0.016743297,
-0.014166378,
0.003798619,
-0.005047023,
0.034261007,
0.023712996,
0.02500813,
0.008652039,
0.008899049,
-0.002850633,
0.0041925004,
0.006505719,
-0.011729655,
-0.0019410342,
-0.016529666,
0.020575296,
0.01857251,
-0.017063744,
0.004890138,
-0.020281555,
0.021603394,
0.032124702,
-0.016569722,
-0.02884013,
-0.017370837,
-0.028039016,
-0.010467899,
0.016369443,
-0.0069429944,
-0.0048934757,
-0.026930807,
-0.037705798,
0.005624493,
-0.0131983645,
0.018265415,
-0.025048187,
0.026356675,
-0.02116278,
0.024153609,
0.005157176,
-0.003968856,
-0.0017390866,
-0.02471439,
0.0042759497,
-0.011656219,
-0.0076506454,
-0.0010848428,
-0.0029691313,
-0.011983341,
-0.011015328,
0.0041324166,
0.0054175383,
-0.008491816,
-0.0039488277,
-0.017571116,
-0.021897135,
0.0022347763,
-0.007777489,
-0.0100539895,
-0.016102405,
-0.023085456,
0.0029424275,
-0.02884013,
0.00093713735,
-0.019880997,
-0.032819,
0.01683676,
-0.01871938,
-0.0061819353,
-0.017477652,
0.040109143,
0.0073235235,
-0.004559678,
-0.03434112,
-0.005107106,
0.010354408,
0.0020578634,
0.038747247,
-0.0030892987,
-0.0064623253,
-0.009900442,
-0.006065106,
0.02312551,
-0.011969989,
-0.031937774,
0.036210384,
-0.002875668,
0.008445084,
-0.0029657935,
-0.0056612105,
-0.016529666,
0.023606181,
-0.0010948568,
-0.01302479,
0.013004762,
-0.00757721,
-0.0023015358,
0.024407296,
0.004673169,
0.007109893,
-0.03108325,
-0.0023899924,
0.007997795,
-0.021496579,
-0.025795894,
0.008124638,
-0.0064122556,
0.0071499487,
-0.009052596,
-0.00029207306,
-0.011262338,
0.008598631,
0.00021331766,
-0.01675665,
-0.0036984796,
0.037064906,
0.016649835,
-0.015568329,
0.02291188,
0.031937774,
0.0055110017,
-0.016649835,
-0.0106815295,
-0.014006156,
-0.017811451,
0.019360272,
0.01550157,
0.0033012603,
-0.03476838,
0.005140486,
-0.018051784,
-0.0045162844,
-0.02192384,
-0.0068762344,
0.02283177,
-0.043313604,
-0.015060957,
-0.0108617805,
0.00945983,
0.014139675,
-0.0060250503,
0.0049301935,
-0.010381112,
0.036637645,
-0.022751657,
0.024660982,
-0.021096021,
0.0029240688,
-0.02108267,
0.016916873,
-0.0349019,
-0.012577501,
0.010427843,
-0.00094882026,
-0.037331946,
-0.02345931,
-0.0012191965,
0.029320799,
0.009406422,
0.022457916,
0.037545577,
-0.010855105,
0.0026470164,
-0.009519913,
-0.002718783,
0.033433188,
-0.023472661,
0.011409209,
0.017557764,
-0.00008798701,
-0.0038453506,
-0.005287357,
-0.023913274,
0.0044461866,
-0.006802799,
-0.017571116,
-0.014833975,
0.023232326,
-0.03743876,
-0.011122143,
0.0046765073,
-0.01243063,
-0.015514921,
-0.0091994675,
0.020802278,
0.0017257347,
-0.03434112,
-0.016062351,
0.008565252,
-0.0053774826,
-0.00576135,
-0.0004431166,
-0.008057879,
-0.0062053013,
-0.021336356,
0.00511712,
-0.03177755,
0.023098808,
0.0008065389,
-0.0008820607,
-0.014833975,
0.017517708,
-0.02046848,
-0.004366075,
0.001984428,
0.017237319,
0.011863174,
0.0020678774,
-0.0077708126,
0.0058481377,
-0.0046030716,
-0.00031502167,
-0.024153609,
-0.025381984,
0.008925753,
-0.009192792,
0.029801467,
-0.004950221,
-0.008351621,
-0.015728552,
0.0071966806,
0.009853711,
-0.0018675987,
0.008919077,
0.011949961,
0.012917975,
-0.022190878,
0.027251253,
0.0018625917,
0.015341347,
0.022311045,
-0.026610361,
-0.00019881832,
0.02255138,
-0.0010047314,
-0.0149941975,
0.0008662053,
0.00810461,
0.009553293,
-0.0029908284,
-0.008805586,
-0.035809826,
0.0008344945,
0.0035916644,
-0.0043226816,
-0.0010155798,
-0.0032979222,
-0.015581681,
0.021963894,
-0.03717172,
-0.010314352,
-0.011182226,
-0.023913274,
0.005771364,
0.004249246,
0.0016139124,
-0.013305181,
-0.0036650999,
-0.0024717727,
-0.022778362,
-0.0020027868,
-0.022217581,
-0.01984094,
-0.02353942,
0.026223155,
-0.014847326,
0.0128378635,
-0.031403698,
0.011375829,
-0.019240106,
0.007457043,
-0.0020261526,
0.02045513,
-0.02451411,
-0.0056945905,
0.017183911,
-0.0053574545,
0.00858528,
0.01787821,
-0.03618368,
-0.0068762344,
0.021750264,
0.18906307,
-0.02961454,
0.012490714,
0.01452688,
-0.0041891625,
0.01281116,
0.010441195,
0.006195287,
-0.02423372,
0.020428425,
0.026890751,
0.010601418,
-0.019360272,
-0.0026253196,
0.0007710729,
0.00075396575,
-0.0384268,
-0.009927146,
-0.015381402,
-0.015795311,
-0.0025568912,
-0.015835367,
0.013298504,
-0.0029140548,
0.03391386,
-0.011088762,
-0.027224548,
-0.016703242,
0.029347502,
0.0015329664,
-0.0015688497,
-0.010634798,
-0.019774182,
0.023419254,
0.009439802,
0.0029090478,
-0.025595615,
-0.0056945905,
0.003511553,
-0.004406131,
0.00873215,
0.01738419,
-0.032979224,
-0.023085456,
-0.016810058,
0.02045513,
0.0038052949,
-0.022057358,
-0.011382505,
0.010321028,
-0.049241852,
-0.017824803,
0.02730466,
0.015701849,
-0.0028072395,
0.0026820654,
0.015688496,
0.029213984,
0.018385584,
0.018278768,
-0.009172764,
0.012650937,
-0.0014011163,
0.02004122,
-0.030842917,
0.0036951415,
0.0014570274,
-0.014914086,
0.0072033564,
0.0021196161,
0.0030592568,
-0.033272963,
-0.018973067,
0.0047632945,
-0.005300709,
-0.009192792,
0.027504938,
0.011916582,
0.0056578727,
0.021656802,
0.007944387,
-0.015888775,
-0.027424827,
0.0062520327,
0.002730466,
-0.028599795,
0.04107048,
0.013792525,
-0.015902128,
-0.009539941,
-0.0003045905,
0.009893767,
-0.022324396,
0.004085685,
0.016035646,
-0.010260944,
0.016930224,
-0.017424244,
0.010047314,
-0.019427031,
-0.027878793,
0.08048533,
-0.010855105,
0.018946363,
-0.018839547,
-0.0015521598,
-0.0007264275,
-0.0040689954,
0.0018792816,
0.0030108562,
0.023512717,
-0.017023688,
0.0027020932,
-0.029027056,
-0.007837572,
0.031804256,
0.02088239,
-0.013819229,
0.026570305,
-0.01183647,
-0.008745503,
-0.006489029,
0.03498201,
-0.0042993156,
-0.017891562,
-0.007443691,
-0.008565252,
-0.014420065,
-0.014019508,
-0.04625102,
0.005147162,
-0.0038119708,
-0.004826716,
0.0070431335,
0.0005386662,
-0.008498492,
0.008158018,
-0.004429497,
-0.006705998,
0.02339255,
0.0055844374,
0.00081822183,
0.009780276,
0.0058681653,
0.008825614,
-0.009439802,
0.01703704,
0.003196114,
-0.019533847,
-0.0055744234,
-0.011636191,
-0.0007168308,
-0.011569432,
-0.0069029387,
0.015368051,
-0.013725765,
-0.01703704,
-0.027611755,
-0.0011332436,
-0.0044595385,
-0.038773954,
0.01612911,
0.007136597,
0.00007004538,
0.002134637,
0.015341347,
-0.16951588,
0.0035215667,
0.01008737,
-0.0090793,
0.029934987,
-0.01619587,
0.015408106,
0.007083189,
-0.0067994613,
0.0064856913,
0.019119939,
-0.0049568973,
-0.024460703,
-0.011682923,
0.0044495245,
-0.00045146153,
-0.008712122,
0.015114364,
-0.0052239355,
-0.0076105897,
0.023152215,
-0.00904592,
0.008364973,
-0.013752469,
-0.010280972,
0.021096021,
-0.014046212,
0.0009997244,
-0.010067342,
-0.0011657889,
-0.005734646,
0.0012242034,
0.024260424,
0.013425347,
-0.009853711,
-0.008238129,
-0.009780276,
-0.007256764,
-0.012891271,
0.04868107,
0.019386977,
0.039334733,
-0.0005211418,
0.014900734,
-0.0098737385,
0.011662895,
0.013238421,
0.010381112,
0.04029607,
-0.008885697,
0.019747477,
-0.019266808,
-0.0026920792,
0.009473181,
-0.0028139155,
0.017504357,
0.0007735764,
-0.009453153,
0.0073635792,
-0.028039016,
-0.018799491,
-0.014566936,
0.017931618,
0.011442589,
0.0195472,
-0.026370026,
-0.0054275524,
-0.013712414,
-0.018906306,
0.00033671854,
-0.018398935,
-0.037038203,
0.011636191,
-0.017798098,
0.04566354,
0.015247883,
-0.008838966,
0.013725765,
0.005651197,
0.0070631616,
-0.018852899,
0.008905726,
-0.04085685,
-0.030923028,
0.0053641307,
0.0072167083,
0.012163592,
0.0098737385,
-0.003922124,
-0.016022295,
0.02500813,
-0.033620115,
-0.013645654,
-0.012337167,
0.003025877,
0.03960177,
0.013565542,
-0.0027671838,
0.009373042,
0.030362248,
0.022671547,
-0.02514165,
-0.008064555,
0.015060957,
0.020081276,
0.0008520189,
-0.051004305,
0.015261236,
0.035168935,
-0.02025485,
-0.008965809,
-0.008985837,
-0.003045905,
0.027131084,
0.0034080755,
0.012724373,
0.00483673,
-0.02408685,
-0.0058214334,
-0.017771395,
0.0698572,
0.016783353,
-0.028786723,
0.0047632945,
-0.0022230933,
-0.00967346,
-0.1320237,
-0.069162905,
0.0025318563,
0.01738419,
0.017851505,
0.019654015,
0.0024484068,
0.011923257,
0.0035315808,
0.034528043,
-0.019493792,
0.0026219818,
-0.0117163025,
-0.014193082,
0.023579476,
-0.009219496,
0.02345931,
0.0027388108,
-0.019293513,
0.032578666,
0.004219204,
-0.018479045,
0.007276792,
-0.008658715,
0.00092545437,
0.006195287,
-0.018746084,
0.043767568,
0.01682341,
0.011642867,
0.0115227,
0.00029457654,
-0.0031360304,
-0.014139675,
-0.012263731,
-0.012944679,
-0.008999188,
-0.0074904226,
0.038587026,
-0.01243063,
0.00033338057,
0.006812813,
0.019774182,
-0.004596396,
0.007837572,
-0.015007549,
-0.040536404,
-0.008685418,
-0.0058748415,
-0.0027888806,
-0.018025082,
-0.0048100264,
-0.024420647,
-0.0043861032,
0.013505459,
-0.03866714,
0.015822016,
0.045503315,
-0.025996173,
-0.013665682,
0.009379718,
0.0014420064,
-0.006335482,
0.015167772,
0.030575879,
-0.031857662,
-0.020842334,
-0.010007258,
0.0153546985,
-0.028252646,
-0.010915188,
0.009887091,
0.0005611975,
-0.006575817,
-0.024073496,
0.016569722,
0.012216999,
-0.0053407648,
0.00049235177,
-0.017811451,
-0.0017641213,
-0.015327995,
0.0084584365,
-0.0089524565,
0.011829794,
0.007977768,
0.018545806,
0.016516315,
0.026223155,
0.0001200629,
-0.0015363044,
0.041604556,
0.013659006,
-0.03135029,
-0.026156396,
0.0014611998,
0.003988884,
-0.00876553,
0.012263731,
0.009887091,
0.0073368754,
-0.01878614,
-0.04998956,
0.02263149,
0.0033897166,
-0.010848428,
-0.010781669,
-0.0012851215,
0.016329389,
-0.014580288,
0.0038420127,
-0.0081646945,
-0.03799954,
0.0018692677,
-0.00046064096,
-0.0073368754,
-0.007917684,
-0.011876525,
0.020441778,
0.011803091,
0.012363871,
0.027264604,
-0.0055243536,
0.025809245,
0.0012217,
0.008411705,
0.0078108683,
-0.0003824071,
0.001292632,
0.008198074,
-0.0021479889,
-0.012604205,
-0.0035482706,
-0.025595615,
-0.011803091,
-0.0014854003,
-0.011102115,
-0.0038420127,
-0.018639268,
0.01913329,
0.011248986,
0.03407408,
0.006375538,
-0.012290435,
0.015448162,
0.003785267,
-0.0012258724,
-0.0029157237,
-0.0010881808,
0.00581142,
0.008879022,
-0.01654302,
0.024767797,
0.02388657,
0.0011983342,
-0.017197262,
-0.0405097,
0.015848719,
-0.00242671,
-0.015888775,
-0.018826196,
-0.018425638,
0.0008753847,
0.0035582846,
0.021416467,
0.0066425763,
0.014393361,
-0.009613377,
-0.01695693,
-0.012664288,
0.03263207,
-0.023192272,
0.00009815741,
0.025996173,
0.008411705,
-0.0038186468,
0.01662313,
-0.0098737385,
-0.0230454,
0.021536633,
0.011022003,
-0.0133318845,
0.0030742777,
-0.02108267,
-0.04002903,
0.02542204,
0.05132475,
-0.015341347,
-0.003651748,
0.02591606,
0.0066292244,
-0.0008215598,
-0.0043326956,
0.033566706,
-0.015394755,
0.0017641213,
0.018038433,
0.0010790013,
-0.003197783,
-0.009733544,
-0.006519071,
0.025608968,
-0.0013927714,
0.0020912432,
-0.00668597,
0.008551899,
0.00027434007,
0.023993386,
-0.02423372,
-0.030736102,
-0.000050043593,
-0.010628122,
0.009519913,
0.018185304,
-0.011929933,
0.005177204,
-0.02213747,
0.008037851,
-0.02053524,
-0.0015004211,
0.0068361787,
-0.00042767843,
0.010554686,
0.02324568,
-0.009319634,
-0.0017941631,
0.0062520327,
0.026476841,
0.056131437,
-0.01155608,
-0.002570243,
0.000794856,
0.031510513,
0.0052072457,
-0.050229892,
-0.026944159,
0.003958842,
-0.03183096,
0.019894348,
-0.010855105,
-0.0047966745,
0.07514456,
0.00754383,
-0.015635088,
-0.016502963,
-0.005450918,
0.021563338,
-0.01682341,
0.010788345,
-0.0074169873,
-0.0015312975,
0.017090447,
-0.019573903,
0.0027721906,
-0.05391502,
-0.021216188,
0.014126323,
-0.0036016782,
0.01794497,
0.008692095,
-0.024153609,
0.006018374,
-0.005140486,
-0.010694882,
-0.0016981963,
-0.029561132,
0.01246401,
0.03986881,
-0.024727741,
0.022951936,
-0.036130276,
-0.020094628,
0.00027162797,
-0.034047376,
-0.0011741337,
0.02996169,
-0.014406713,
-0.011582783,
-0.02827935,
0.031724144,
0.003645072,
-0.013064845,
0.0044762283,
-0.012417278,
-0.004369413,
-0.017971674,
-0.0147939185,
-0.012917975,
0.0027087692,
-0.02179032
] |
Obesity and insulin resistance, the key features of metabolic syndrome, are closely associated with a state of chronic, low-grade inflammation characterized by abnormal macrophage infiltration into adipose tissues. Although it has been reported that chemokines promote leukocyte migration by activating class IB phosphoinositide-3 kinase (PI3Kγ) in inflammatory states, little is known about the role of PI3Kγ in obesity-induced macrophage infiltration into tissues, systemic inflammation, and the development of insulin resistance. In the present study, we used murine models of both diet-induced and genetically induced obesity to examine the role of PI3K | [
-0.021165702,
-0.019409372,
-0.013666044,
-0.032819018,
-0.013242986,
0.011403327,
-0.021575939,
0.008070145,
-0.016960766,
-0.026870571,
0.03545992,
-0.010480291,
0.010935399,
0.0095572565,
-0.013127607,
-0.0056503834,
0.04343392,
-0.006852252,
-0.014935217,
0.00015494086,
-0.042280123,
0.0131917065,
0.0019502316,
-0.026409052,
0.0027562845,
0.0326139,
0.0037338042,
-0.0468953,
-0.01972987,
-0.008461153,
0.0053298855,
-0.0024101466,
-0.023511749,
0.020781104,
-0.012428921,
-0.008448333,
0.022806654,
-0.004666454,
0.0052497606,
-0.027691046,
0.0053106556,
-0.0033620263,
0.0010239918,
0.0037081644,
0.0014670806,
0.0064452193,
0.014191661,
-0.02484502,
-0.00722403,
0.016947946,
0.014653178,
-0.0028203842,
-0.0073906886,
-0.011653315,
-0.0070701907,
0.005922807,
-0.013140427,
0.011928944,
-0.0009158236,
-0.03630604,
-0.0036985495,
-0.004003023,
-0.021781059,
-0.008736782,
-0.006515729,
0.012698139,
-0.0031937647,
0.025588578,
0.016012091,
0.004131222,
0.037998267,
0.04507487,
0.00044909812,
-0.0014318258,
0.015294175,
-0.017204344,
-0.016460788,
0.020332407,
0.0044036456,
0.0010985077,
0.023024593,
-0.014614719,
-0.0027755145,
0.047664493,
0.01772996,
-0.0034229208,
0.0075637577,
0.037485473,
0.018576076,
-0.021216981,
0.0028860865,
0.00020571979,
0.027306449,
0.018627357,
-0.006249715,
0.022627175,
-0.013653224,
0.027178248,
0.0026425077,
-0.012140472,
-0.02707569,
0.008025276,
-0.0012427318,
-0.024691183,
-0.031870343,
-0.0051151514,
-0.017409462,
0.012127653,
0.0250245,
-0.011428966,
-0.015165975,
0.045331266,
0.0004971729,
-0.028537162,
0.007576578,
-0.019614492,
0.0058138375,
0.00719839,
-0.0021200958,
-0.036716275,
0.010935399,
0.050792556,
0.0107431,
-0.004833113,
0.017409462,
0.008076555,
-0.011095649,
0.011691775,
-0.039895616,
0.0037946987,
0.005554234,
0.01638387,
0.027767966,
-0.016717186,
-0.01980679,
0.016460788,
-0.04112633,
-0.009390597,
-0.027409008,
-0.033767693,
-0.008582942,
0.028357683,
-0.010512342,
-0.0016569757,
0.0035318902,
0.006143951,
0.034562528,
0.003778674,
0.007973996,
0.0065605985,
-0.014050642,
-0.008563712,
0.011441786,
-0.0071022403,
0.013807063,
0.008538072,
-0.022498975,
0.031562664,
-0.022281036,
-0.020999042,
0.009961084,
-0.016832566,
-0.0012731792,
0.035434283,
0.017037686,
0.0014967266,
0.01989653,
0.012884028,
0.0018268399,
0.0021040707,
0.01435832,
0.043895435,
-0.011723825,
0.033177976,
-0.0026264829,
0.023537388,
0.0017563303,
0.0134737445,
-0.008358593,
-0.007897076,
-0.02499886,
0.024396325,
0.033075415,
-0.0010536378,
-0.01811456,
-0.0006518132,
0.036921393,
-0.012864798,
-0.0092559885,
-0.04138273,
0.01808892,
0.031229345,
-0.013307086,
-0.031357545,
-0.6342275,
-0.011319997,
0.0037145743,
-0.011800745,
0.0044100555,
0.042767283,
0.020229848,
-0.014435239,
-0.009813655,
0.029511476,
-0.017537663,
0.018319678,
0.008082965,
-0.02697313,
-0.0103456825,
-0.031588305,
-0.016665908,
-0.031537026,
-0.003769059,
0.00016525689,
-0.002975826,
-0.02352457,
0.001615311,
0.030229392,
-0.002030356,
0.020704184,
0.018101739,
-0.007300949,
-0.003586375,
0.033306174,
-0.011448196,
0.0179479,
0.0026024454,
-0.0045799194,
0.04510051,
-0.012678909,
-0.014153201,
0.045279987,
0.037254713,
0.019127334,
-0.02863972,
-0.0118199745,
0.014089102,
0.01271096,
-0.013460925,
0.042639084,
0.0072881295,
0.026947489,
0.0027210298,
-0.0074099186,
-0.010608491,
0.020960582,
-0.026793651,
0.0009046062,
0.04340828,
-0.013755783,
0.0062336903,
-0.013576305,
0.0059580617,
0.029665316,
0.0119609935,
0.03571632,
0.00156964,
-0.027460286,
-0.022832293,
0.023742508,
-0.013108377,
0.0003040727,
-0.009031639,
0.015678773,
0.033152334,
0.024229664,
0.00717275,
0.022063097,
0.006047801,
0.020781104,
0.0061888206,
0.049818244,
-0.017409462,
0.0124032805,
-0.0043876204,
-0.0004971729,
-0.02707569,
0.008602172,
0.014858297,
0.012877618,
-0.012967357,
0.0015295778,
-0.010300812,
-0.021050323,
0.015165975,
0.00024137522,
-0.046100464,
-0.027357727,
-0.015371094,
0.019229893,
-0.016858205,
0.020076009,
0.007345819,
-0.008300904,
-0.035357364,
-0.0049452875,
-0.018178659,
0.0022002202,
0.038100827,
-0.0035415052,
-0.039895616,
-0.013550664,
0.049638763,
-0.03766495,
0.01612747,
-0.00091822736,
-0.008018865,
-0.020845205,
0.0006425989,
-0.021268262,
0.022960491,
-0.0059869066,
0.0042850613,
-0.020614445,
0.017396644,
-0.0121020125,
0.012396871,
-0.0022531024,
0.00043387446,
0.035203524,
-0.0028732666,
-0.0069099413,
-0.011178978,
0.0017835726,
0.011217438,
0.019191433,
0.02335791,
-0.012826338,
0.010499521,
-0.0010007557,
0.017909441,
-0.00031569073,
0.0072753094,
-0.03594708,
-0.008602172,
-0.007871436,
0.014473699,
-0.015550573,
0.003573555,
0.002261115,
0.014166021,
-0.007813746,
0.020845205,
0.011012319,
-0.0011794334,
0.0028604465,
0.0065573934,
0.004807473,
0.035254803,
-0.0022931646,
-0.004291471,
-0.0051472015,
-0.0145249795,
-0.00359599,
-0.013973722,
0.0028075643,
-0.022922032,
-0.0060253665,
-0.020781104,
-0.027255168,
0.017422283,
0.00886498,
-0.037870068,
-0.025665497,
-0.0065702135,
-0.0119609935,
-0.026537253,
0.005964472,
0.013499385,
0.03066527,
0.0006742481,
-0.014832658,
-0.0039228983,
-0.008095785,
0.027485928,
-0.00444531,
-0.017371003,
0.010262352,
0.027485928,
0.0018076099,
0.014230121,
0.02162722,
0.0051632263,
0.042203207,
-0.035177883,
0.016973585,
0.0063907346,
0.012063553,
0.010916169,
-0.02356303,
0.008397053,
0.012210982,
-0.0024502089,
0.015063416,
-0.0034485608,
-0.034562528,
0.00718557,
-0.029383276,
0.016665908,
-0.034229208,
0.007025321,
-0.023832247,
0.026947489,
0.013121197,
0.01080079,
0.020999042,
-0.00045630932,
-0.0074740183,
0.010922579,
0.016576167,
0.003426126,
-0.0049549025,
-0.00096710335,
-0.030383231,
-0.004874778,
-0.004823498,
0.029998632,
-0.021857979,
-0.020524705,
0.025780877,
0.026691092,
0.018242758,
-0.008621402,
-0.015486474,
-0.0033492064,
0.0068778917,
-0.0010416192,
0.011268717,
0.0024229665,
-0.0019053619,
-0.0064836787,
-0.016089011,
0.033690773,
0.010570031,
0.03428049,
0.01630695,
0.020691365,
-0.008653452,
-0.023934806,
-0.010396962,
0.029024318,
0.022806654,
-0.022306675,
0.015806971,
-0.014742918,
0.0107431,
-0.0038011088,
0.0040286626,
0.00095428346,
-0.012005863,
0.016960766,
0.0037402143,
0.033434372,
0.013781424,
-0.002717825,
-0.013883983,
-0.025562938,
-0.007871436,
0.009307268,
0.011659725,
0.013204526,
0.0011297562,
0.00017417075,
0.0028460242,
-0.0395623,
0.006422784,
0.0052689905,
-0.035203524,
0.002956596,
0.0073329993,
0.03784443,
-0.018691456,
0.030075552,
0.025486019,
0.009031639,
-0.033588212,
0.035434283,
0.012185342,
-0.012428921,
-0.016409509,
-0.037177794,
-0.002809167,
0.00020852416,
0.014576259,
-0.0036664996,
0.024627082,
0.0065317536,
-0.005727303,
-0.031152427,
-0.0060349815,
0.033844613,
-0.02331945,
0.02676801,
0.022845114,
0.0178838,
0.012249442,
-0.00029325587,
-0.004890803,
0.030203752,
-0.003986998,
0.0058138375,
-0.014050642,
-0.016871026,
-0.018383777,
0.005608719,
-0.0071214703,
0.011018729,
0.00055846816,
-0.0020463811,
0.016704367,
-0.0023845066,
-0.0016353421,
0.028485881,
-0.014025002,
-0.0037209843,
-0.034870207,
-0.0009999544,
0.0017499202,
0.01978115,
0.013358366,
-0.0032161996,
0.0098008355,
0.00091422116,
0.011800745,
0.015806971,
-0.039767418,
0.014922397,
-0.0064836787,
-0.003951743,
0.014589079,
0.017601762,
0.0058587072,
0.019165793,
0.013781424,
0.006826612,
-0.031562664,
-0.0019470267,
-0.003063963,
0.012217392,
0.0052625807,
0.031024227,
0.029998632,
0.01966577,
-0.0056119235,
0.00049557036,
0.023050232,
-0.020434966,
-0.033511292,
-0.016935125,
0.0063682995,
-0.0016177148,
0.00452864,
-0.009127789,
-0.021101603,
0.00018538818,
0.00022254595,
-0.00010716659,
-0.009313678,
0.00178197,
0.021806698,
0.0016441558,
0.010954629,
0.0011978621,
-0.0009222336,
-0.010711051,
0.018806836,
0.00009044059,
-0.0047529885,
0.03420357,
-0.01598645,
-0.01792226,
-0.020832384,
0.010614901,
0.011428966,
0.0037017544,
-0.019088874,
-0.013127607,
-0.007691957,
-0.004291471,
-0.025806516,
0.0063106096,
-0.029178157,
-0.0055382093,
-0.010031594,
0.004320316,
-0.02851152,
-0.01808892,
0.014935217,
0.022050276,
-0.040177654,
-0.007916306,
-0.008204754,
0.0016842181,
0.0066663628,
0.004903623,
-0.0049709273,
0.009813655,
0.025550118,
-0.010941809,
0.0011001101,
-0.00029806333,
-0.038818743,
0.009326498,
-0.0028155767,
0.0024950786,
-0.01612747,
-0.012082783,
-0.0112751275,
0.00080324867,
-0.014025002,
0.0023508545,
0.01621721,
-0.0060253665,
-0.023793787,
0.005762558,
-0.011249487,
-0.008486792,
-0.013755783,
0.017242804,
-0.02488348,
-0.015550573,
-0.003204982,
-0.018242758,
-0.024511704,
0.015012137,
-0.012044323,
-0.010845659,
0.007897076,
0.015345454,
-0.01439678,
-0.0013300676,
-0.008832931,
0.010441832,
0.025921896,
0.017281264,
0.016896665,
0.019088874,
-0.0009262398,
-0.017640222,
0.004105582,
0.008018865,
0.013255806,
-0.004740169,
0.004144042,
-0.010140563,
-0.0038395687,
-0.022357956,
-0.021768238,
-0.00715993,
0.024601443,
-0.0028700614,
-0.01993499,
-0.020806745,
0.004740169,
-0.0067817424,
0.006659953,
-0.014871117,
-0.017486382,
-0.025011681,
-0.0013124401,
0.001177831,
-0.015589033,
0.03420357,
-0.036203478,
-0.0022515,
0.0026441102,
-0.03228058,
0.0061792056,
-0.009653406,
-0.0009454697,
-0.0068650716,
-0.003948538,
-0.01081361,
-0.024050185,
-0.008691912,
-0.011230257,
0.03607528,
0.03766495,
0.031537026,
0.014973677,
0.037870068,
0.0049388777,
0.0042273714,
-0.0071342904,
-0.00543565,
0.0076470873,
-0.023819428,
0.015550573,
0.02333227,
0.0058170427,
0.01080079,
-0.016499247,
0.011608445,
0.0006337852,
-0.005810633,
0.0021088782,
-0.013999362,
-0.0250886,
-0.01947347,
0.027357727,
-0.020486247,
-0.005038232,
-0.042844202,
-0.019178614,
0.022793833,
0.00717916,
0.021973358,
0.006621493,
0.016435148,
-0.03233186,
0.050972037,
-0.011403327,
-0.0028957014,
0.00007471615,
-0.0002533939,
0.011621266,
0.020909304,
0.0026809676,
-0.006634313,
-0.005195276,
-0.023729688,
0.0009102149,
0.0008152673,
-0.0028860865,
-0.02162722,
-0.0042241663,
-0.020742644,
-0.023691228,
-0.00894831,
-0.0040735323,
-0.015909532,
-0.042203207,
-0.0025399483,
-0.003599195,
-0.03212674,
0.010787969,
-0.015422374,
-0.020217028,
0.027716685,
0.013807063,
0.0067625125,
-0.020217028,
0.034459967,
0.0092752185,
0.019947808,
-0.013883983,
0.0060253665,
-0.007371459,
-0.0058362726,
0.020819563,
0.008935491,
-0.0038107238,
-0.0060413913,
-0.0027210298,
-0.0032706843,
-0.009890575,
-0.034665085,
0.025550118,
-0.005323475,
0.005874732,
-0.009512387,
-0.017435104,
-0.0399469,
0.010691821,
-0.008320133,
0.0063522747,
0.009403418,
0.0069355816,
-0.010089284,
0.034947127,
0.011736644,
0.007743237,
-0.00007181163,
-0.027511567,
0.009467517,
-0.033921532,
0.001334875,
0.017088965,
0.012819928,
0.026665451,
0.01260199,
0.010114924,
0.013858343,
0.028203843,
0.0031136402,
0.0016241247,
-0.0022178476,
0.04448515,
0.00897395,
-0.011646905,
0.016319769,
-0.029972993,
0.026511611,
-0.012704549,
-0.009262399,
-0.022704093,
-0.010544391,
0.009627766,
0.015178795,
-0.0005404401,
-0.0180761,
0.00635548,
-0.022447694,
-0.015845431,
-0.0251527,
-0.016371049,
-0.004640814,
-0.020627266,
-0.0040767374,
-0.016653087,
-0.005160021,
0.020601625,
0.02144774,
0.012493021,
-0.01629413,
0.010159793,
-0.0326139,
0.017024865,
0.005970882,
0.01251866,
0.0111725675,
0.013691683,
-0.03246006,
-0.027537206,
0.0129096685,
-0.000025940324,
-0.03040887,
-0.011050778,
-0.0076214476,
0.00040342714,
0.01785816,
0.010826429,
0.020652905,
0.012813519,
0.019537572,
0.004999772,
0.0059901117,
0.026665451,
-0.040357135,
-0.009384188,
0.025447559,
-0.011018729,
-0.0035479153,
-0.0028796764,
0.0049709273,
0.021793878,
-0.0071150605,
-0.029716594,
-0.007416329,
0.026639812,
-0.029639674,
0.015306994,
0.002565588,
-0.022396415,
-0.020204207,
0.01448652,
0.0091149695,
0.0029790308,
-0.021152882,
0.018165838,
-0.004185707,
0.000121889476,
-0.025319358,
-0.005192071,
-0.005801018,
-0.0031264601,
-0.033536933,
0.015819792,
-0.044510793,
0.03545992,
-0.0010904951,
-0.010993089,
-0.020409327,
-0.00313287,
-0.031562664,
-0.024934761,
-0.010390552,
0.0045670997,
-0.022152837,
0.000745559,
-0.011602036,
0.011563576,
0.004720939,
0.0028876888,
-0.012210982,
-0.0057080733,
-0.0047754236,
-0.024755282,
0.016691547,
0.006480474,
-0.003051143,
-0.022947673,
0.045049228,
0.008390644,
0.0034998404,
0.027306449,
-0.019447831,
0.0033363865,
-0.0014366333,
-0.00009710094,
0.018601716,
0.013460925,
0.05933063,
-0.024268124,
0.009006,
0.029024318,
0.006820202,
0.008557302,
-0.021140061,
0.0038716185,
-0.0049933624,
-0.0009863332,
-0.0067689223,
-0.03381897,
-0.008614992,
-0.010031594,
0.022357956,
0.008204754,
-0.005570259,
-0.0047818334,
-0.0013332726,
-0.036024,
-0.022191297,
-0.0037434192,
-0.0050798967,
0.00269539,
0.007999635,
0.020358047,
-0.010275173,
-0.0014366333,
0.0032674794,
-0.013909622,
-0.015024956,
0.0060157515,
0.022793833,
-0.01617875,
0.0031841497,
0.018332498,
-0.007858616,
-0.010595671,
0.0039613578,
-0.027742326,
-0.021011863,
0.015794152,
0.001958244,
-0.009544437,
-0.013422465,
0.007416329,
-0.0036376547,
0.008582942,
-0.025524478,
-0.03584452,
-0.015781332,
0.033690773,
0.18994007,
-0.019986268,
-0.0027594897,
0.029690955,
0.0009470722,
0.0045767147,
0.009781606,
-0.0026473152,
-0.017229984,
0.0072496696,
0.036280397,
0.008256034,
0.0014117947,
0.0015159566,
0.006256125,
-0.0022370776,
-0.01271096,
-0.015665952,
-0.004852343,
-0.020229848,
-0.0042209616,
-0.0056632035,
0.017153064,
-0.013563485,
0.021281082,
0.007897076,
-0.020896483,
0.017704321,
0.015755692,
0.0041985265,
-0.01975551,
0.021832338,
-0.006294585,
0.01256994,
-0.0043651857,
0.02348611,
-0.022152837,
-0.015448014,
0.019332452,
-0.005791403,
0.0048010633,
-0.0036729095,
-0.008236804,
0.0026409053,
-0.0075252983,
-0.006583033,
-0.01255071,
0.014755738,
-0.0040382775,
0.007993225,
-0.016050551,
-0.026947489,
0.013973722,
0.015601853,
0.012089193,
-0.009364958,
0.013563485,
0.018242758,
0.009916215,
-0.017512022,
-0.0076406775,
-0.007832976,
-0.01448652,
0.021191342,
-0.028537162,
0.047664493,
-0.006871482,
-0.006448424,
-0.018242758,
-0.0070573706,
0.0046087643,
-0.0006494095,
0.0046311994,
-0.021319542,
0.004099172,
0.0025816131,
0.029767875,
0.009230348,
0.012819928,
0.011025138,
-0.009185479,
-0.010602081,
-0.022934852,
-0.021229802,
-0.008006046,
-0.026152654,
0.030101193,
-0.0005095922,
-0.038587984,
0.016089011,
-0.007538118,
0.00011367671,
-0.014550619,
-0.0074868384,
0.002156953,
-0.017294083,
-0.004711324,
-0.0040446874,
-0.014063462,
-0.008159884,
-0.035331722,
0.079534836,
-0.0017354978,
-0.01082002,
-0.031152427,
-0.0045799194,
0.0020575984,
0.007845797,
0.009634176,
0.0011441787,
-0.0042401915,
-0.02689621,
-0.0013372788,
-0.013358366,
0.0015608263,
0.0146659985,
0.010172613,
-0.0069099413,
0.00903805,
-0.020063188,
-0.012800699,
-0.009422648,
0.020845205,
0.022652814,
-0.028024364,
0.0112943575,
-0.017473564,
0.012082783,
-0.009685456,
-0.038562346,
0.0022787424,
-0.012448151,
-0.0076406775,
0.012178932,
-0.018358137,
-0.00036636952,
0.0025719982,
0.0072945394,
0.0011946571,
0.028152563,
-0.011730235,
-0.0036793195,
0.011037959,
-0.0062144604,
0.013121197,
-0.022229755,
0.00888421,
0.0125443,
-0.012268672,
-0.014512159,
-0.028614081,
-0.024268124,
-0.0069419914,
-0.0064259893,
0.0249604,
-0.024819382,
-0.017204344,
-0.031562664,
-0.0014206084,
0.024524523,
-0.023050232,
0.028126923,
0.010595671,
-0.003986998,
-0.021691319,
-0.005868322,
-0.158762,
0.009384188,
0.019268353,
-0.025947535,
0.0216785,
0.014191661,
0.0070766006,
-0.0007355434,
0.017127424,
-0.0022210525,
0.036613718,
-0.00029125274,
-0.033844613,
0.005791403,
0.022678453,
-0.0038171338,
0.00223227,
0.024460424,
0.005006182,
0.008403463,
0.036280397,
-0.03561376,
0.015627492,
-0.011512296,
-0.019960629,
0.018960675,
-0.0018973494,
0.00058170425,
0.0030367207,
-0.021011863,
-0.01256994,
0.0037145743,
0.027639765,
0.004134427,
0.024768103,
0.0013220551,
0.013255806,
-0.0028187819,
-0.008698322,
0.013678864,
0.055125695,
0.028408961,
-0.0048106783,
0.014781377,
-0.013255806,
0.0045703044,
0.007345819,
0.018806836,
0.02160158,
-0.010044414,
0.014114741,
-0.0072945394,
0.0062048454,
0.01979397,
0.012332771,
0.020793924,
-0.0045446646,
0.015768513,
-0.0115763955,
-0.019499112,
-0.012268672,
-0.015371094,
0.029742233,
-0.0053010406,
0.013781424,
-0.009839295,
0.010281582,
0.00021493412,
-0.004012638,
0.0087303715,
-0.014230121,
0.0011930546,
-0.0011329612,
-0.0061856154,
0.016319769,
0.011877663,
-0.010845659,
0.013345546,
0.0015127516,
0.022883572,
0.0005011791,
-0.006794562,
-0.039767418,
-0.012210982,
-0.010230303,
0.0125443,
0.03443433,
0.0012371232,
-0.003916488,
-0.0062048454,
0.00446454,
-0.035024043,
0.011358457,
-0.013896802,
0.0039613578,
0.014845477,
0.0045670997,
0.011396917,
0.0044389004,
-0.001256353,
0.020255487,
-0.020883664,
-0.003054348,
0.013448105,
0.016435148,
-0.01621721,
-0.024178386,
-0.0044164653,
0.03951102,
-0.015204435,
-0.0013068315,
-0.009736735,
0.006281765,
0.026165474,
-0.0126084,
0.016832566,
0.018935034,
-0.015371094,
0.009127789,
-0.02681929,
0.054510336,
-0.0039709727,
-0.006067031,
0.032793377,
0.0028604465,
-0.01244174,
-0.1266609,
-0.031049866,
0.0035286853,
0.00033391907,
-0.00052361394,
0.0059676766,
-0.012678909,
-0.0033588214,
-0.02144774,
0.01974269,
-0.011800745,
-0.01077515,
-0.00064860826,
-0.0056535886,
0.00038840377,
-0.004320316,
0.014089102,
-0.016050551,
-0.018819654,
0.018999133,
-0.009313678,
-0.026716731,
0.019050414,
-0.0010760728,
0.0004943685,
0.025498837,
-0.030947307,
0.022409236,
0.010409782,
0.007365049,
0.034998406,
0.018499156,
0.0117174145,
0.00052922266,
-0.010358502,
-0.021960538,
-0.004301086,
-0.016447969,
0.035818882,
0.0010304018,
0.013537845,
0.018486338,
0.013986542,
-0.0021200958,
-0.03246006,
0.010390552,
-0.013281446,
-0.010146974,
0.0042498065,
-0.023165612,
-0.025588578,
-0.040664814,
-0.028332042,
-0.0033395914,
0.00629779,
-0.00719839,
-0.009589307,
0.027280807,
0.013063507,
-0.0035318902,
-0.0003062761,
0.0016425534,
-0.02329381,
0.03207546,
0.022883572,
-0.03266518,
0.010961039,
-0.02715261,
0.003067168,
-0.019076053,
0.01619157,
0.0016225222,
0.0009590909,
-0.0064003495,
-0.008236804,
-0.011037959,
-0.0014502545,
-0.029383276,
0.011666135,
-0.017088965,
-0.013858343,
-0.020473426,
0.01984525,
-0.020511886,
0.025639856,
0.0028107692,
0.012031503,
0.002421364,
0.01066618,
-0.0072112097,
-0.012999408,
0.038587984,
0.0056920485,
-0.015499294,
0.0026264829,
0.009832885,
-0.0045638946,
-0.010416192,
0.017268443,
0.009223939,
-0.015576214,
-0.0045254347,
-0.049433645,
0.022498975,
-0.0072112097,
-0.0066855927,
-0.015845431,
-0.019011954,
-0.022678453,
-0.021691319,
0.0079227155,
0.026383413,
-0.01976833,
0.02322971,
0.004797858,
0.005150406,
-0.018345317,
-0.017563302,
0.013819883,
0.014922397,
0.005220916,
0.005265786,
-0.016755646,
0.0004382813,
0.01259558,
-0.0068843015,
0.005759353,
0.0007884256,
-0.020678544,
0.04151093,
-0.022332316,
-0.01087771,
-0.0054644947,
-0.04128017,
0.001703448,
0.0005152009,
-0.01615311,
-0.036049638,
-0.0007832175,
0.036485516,
0.026511611,
0.038382865,
0.01070464,
-0.028255122,
-0.0020912508,
-0.01780688,
0.016524889,
-0.015204435,
-0.0047081187,
-0.0032947217,
-0.0019470267,
-0.002447004,
0.029152518,
0.011864844,
-0.008063735,
-0.040228937,
-0.023870707,
0.00443249,
0.023037411,
0.0057978127,
-0.017447922,
-0.029485837,
0.015563393,
0.02530654,
0.010602081,
0.0017787651,
0.025780877,
-0.03056271,
-0.040818654,
0.0038716185,
0.002169773,
-0.0463825,
-0.019576032,
0.0002077229,
0.0058042225,
-0.012255852,
0.00716634,
-0.0058330675,
-0.015845431,
-0.0022579099,
0.008614992,
0.027870525,
-0.000129301,
0.00046512304,
-0.015332635,
-0.012172522,
0.02526808,
0.005961267,
-0.015858252,
0.03058835,
0.002972621,
0.003935718,
0.005961267,
0.031306267,
0.022819472,
0.007961175,
0.013678864,
0.022152837,
0.00268898,
0.0027194275,
0.00050638715,
0.02697313,
0.006111901,
-0.015255715,
-0.01249943,
-0.021050323,
-0.009050869,
0.008794471,
-0.035383005,
-0.027793605,
-0.021960538,
0.012332771,
0.01815302,
0.029793514,
-0.0035383003,
0.007326589,
-0.00898036,
0.025832156,
-0.026101375,
-0.012025093,
-0.010909759,
0.022550255,
0.010371322,
0.015730053,
-0.0106277205,
0.0003431334,
-0.002355662,
0.010993089,
0.029049959,
-0.019601671,
0.02175542,
0.005570259,
0.027306449,
0.0042562163,
-0.025434738,
-0.009473927,
-0.022165656,
-0.0180761,
0.013127607,
0.009826475,
-0.003243442,
0.08389361,
0.0015632301,
0.0023588669,
0.011775104,
-0.019114513,
0.021691319,
0.005557439,
0.0063682995,
-0.027024409,
-0.010076464,
0.0014206084,
-0.020204207,
0.007935536,
-0.047305536,
-0.02492194,
-0.005791403,
-0.0049388777,
-0.0054933396,
-0.009358548,
-0.025511658,
0.0070958305,
0.0059388317,
0.0005420426,
0.016473608,
-0.024037367,
0.001305229,
0.045818426,
-0.00312005,
0.028024364,
-0.060766462,
-0.000022046772,
0.012435331,
-0.05574105,
-0.013230166,
0.021986177,
-0.02712697,
-0.014242941,
-0.016537707,
0.015396734,
0.006672773,
-0.013755783,
-0.01265327,
-0.034152288,
-0.028844839,
-0.011358457,
0.007999635,
-0.024114287,
0.0000151610675,
-0.032793377
] |
BACKGROUND Frail and dependent older people in resource-poor settings are poorly served by health systems that lack outreach capacity. The COPE (Caring for Older PEople) multidimensional assessment tool is designed to help community health workers (CHWs) identify clinically significant impairments and deliver evidence-based interventions METHODS Older people (n = 150) identified by CHWs as frail or dependent, were assessed at home by the CHW using the structured COPE assessment tool, generating information on impairments in nutrition, mobility, vision, hearing, continence, cognition, mood and behaviour. The older people were reassessed by local physicians who reached | [
-0.00037068152,
0.005605923,
0.024901673,
-0.049153384,
-0.0045497348,
0.040974695,
0.02576829,
0.009024994,
0.0009368594,
-0.026729692,
-0.013507024,
0.022017466,
-0.009891611,
0.017196914,
-0.02857125,
0.0054061953,
0.031604405,
-0.007461023,
-0.003984403,
-0.023412175,
-0.041651737,
0.023574667,
-0.0043026134,
-0.0019752753,
0.00786725,
0.0041198116,
0.026066188,
-0.027379652,
0.01018951,
-0.032660596,
0.030358646,
-0.018239561,
-0.012383132,
-0.034204256,
-0.013879399,
-0.010352001,
0.009065617,
-0.012565934,
0.007521957,
-0.022450773,
0.017047964,
0.0016545259,
-0.013290371,
0.006905847,
-0.0016232126,
0.014691851,
-0.0042992285,
-0.016208429,
-0.02564642,
0.020202989,
-0.0036628072,
0.009207796,
0.0018923376,
0.006888921,
0.032010633,
-0.015111619,
0.009647875,
0.026377628,
0.008456278,
-0.0058259624,
-0.01020305,
0.0046986844,
-0.016235512,
0.038239438,
-0.0000693441,
0.009471843,
0.013974185,
0.009749431,
0.026810937,
-0.000020813808,
0.060771454,
0.020758165,
0.003642496,
0.008564604,
0.017521895,
0.010108264,
-0.016777147,
0.0016342145,
0.013148191,
0.012464377,
0.008347951,
-0.030223237,
-0.027298408,
0.021232095,
-0.0056228493,
0.0015563546,
0.0025693814,
0.012119085,
0.0130940275,
0.0061712544,
0.0034156863,
0.0053181793,
0.015084537,
0.009898381,
0.0021783886,
0.0053147944,
0.02732549,
0.01929575,
-0.00043669328,
-0.016303215,
-0.03750823,
0.022437233,
-0.048638828,
-0.010297837,
-0.016330298,
-0.0123763615,
-0.0035138575,
-0.0015098078,
0.009580171,
-0.0015292728,
-0.02224766,
0.021800812,
-0.008124527,
-0.003373371,
-0.00051666907,
-0.020189447,
-0.015247027,
-0.005494211,
0.0062728114,
-0.018334348,
0.017318781,
0.012579475,
0.031441916,
-0.01018951,
0.0007142813,
-0.011069667,
-0.033283476,
0.006916003,
-0.003390297,
-0.02253202,
-0.011069667,
0.0038862317,
0.033743866,
-0.0069667813,
-0.023886107,
-0.00050439767,
-0.011543597,
-0.01604594,
-0.022450773,
-0.01281644,
0.008429196,
0.026133893,
-0.017359404,
-0.015991775,
-0.008117756,
0.018713491,
0.03582916,
0.016804228,
-0.0336897,
-0.0012059844,
0.013716908,
0.0024255095,
-0.013364846,
-0.0043127695,
0.01482726,
0.013987726,
0.025294358,
0.014001267,
-0.016587574,
-0.040703874,
-0.019336373,
-0.018645788,
-0.0057988805,
-0.0038523795,
-0.02518603,
0.014190839,
-0.012464377,
0.012437295,
0.017521895,
0.034339663,
0.0069396994,
0.036885347,
-0.0006880458,
0.01730524,
0.0068042907,
-0.011956594,
-0.0025744592,
0.043872442,
-0.025687043,
-0.04138092,
-0.027555684,
0.018022908,
0.013906481,
-0.010480639,
-0.0048814863,
-0.010020249,
0.020785246,
0.013452861,
-0.004668217,
-0.019986335,
0.023574667,
0.008083903,
0.010372312,
-0.004847634,
-0.63046324,
-0.01929575,
-0.016398001,
-0.027867125,
-0.00540958,
0.012755506,
0.032173123,
0.017251078,
-0.03536877,
0.035097953,
0.004465104,
0.020324856,
-0.0069126175,
-0.0027775725,
-0.012857063,
-0.010839472,
-0.0033327483,
-0.042951662,
0.030954445,
0.007196976,
-0.013865858,
0.022884082,
-0.012403443,
0.013906481,
-0.025402686,
0.002246093,
0.039756015,
-0.02379132,
0.0059546004,
0.016005317,
-0.00424845,
0.036424957,
-0.011130601,
0.015206405,
0.054948878,
-0.011990447,
-0.022518478,
0.008368262,
-0.0035544802,
0.02453607,
-0.010081183,
-0.0057413317,
0.010128576,
-0.018104153,
-0.014366871,
-0.008151608,
-0.011794103,
-0.016330298,
-0.00007569139,
-0.0075151864,
0.013452861,
-0.0029282146,
0.0030940904,
0.004309384,
-0.003104246,
-0.0064793094,
0.008226083,
-0.03674994,
0.0021614626,
0.022125794,
0.000012119349,
0.03444799,
-0.018605165,
-0.035260443,
-0.01158422,
0.02222058,
-0.011469123,
-0.010880095,
0.00051243755,
0.007081879,
0.020704001,
0.009146863,
-0.03136067,
-0.0098171355,
0.022748673,
0.021137308,
0.0036187994,
-0.003507087,
-0.0028503546,
-0.011171224,
0.007921413,
0.015409518,
0.002518603,
0.010839472,
0.024278792,
-0.0055653006,
-0.024265252,
-0.017521895,
-0.0020632911,
-0.015274109,
0.024278792,
0.011997217,
0.0039742473,
-0.027420275,
-0.018754115,
0.0029315997,
-0.010751456,
0.00059072074,
0.019160341,
-0.040108077,
-0.025578717,
-0.01960719,
0.009092699,
0.00058310403,
0.007075108,
0.02269451,
-0.01714275,
0.013879399,
0.05681752,
-0.016303215,
0.003926854,
-0.004800241,
-0.008672931,
0.0016139032,
0.008740636,
-0.027014049,
0.025822451,
0.0025812297,
-0.0077995453,
-0.042951662,
0.019580107,
0.008266705,
0.022058088,
-0.011252468,
0.017982284,
0.0068753804,
0.010622818,
-0.014177298,
-0.008253165,
-0.0035612506,
0.016167806,
-0.04352038,
0.008097445,
-0.010236903,
0.0308732,
0.013249748,
-0.0111983055,
-0.015111619,
0.0043906295,
-0.019553026,
-0.018957227,
-0.0077115293,
0.01776563,
-0.010751456,
0.012240953,
-0.02515895,
-0.0062254183,
-0.012884145,
0.0011805953,
-0.0058733555,
-0.016601115,
-0.028625414,
-0.020771705,
0.0010307992,
-0.010324919,
-0.019999875,
-0.0021394584,
-0.019282209,
-0.0071834354,
-0.037779048,
-0.005311409,
0.018781196,
-0.022369528,
-0.015517845,
0.004989813,
0.0065131616,
0.025578717,
0.02438712,
-0.0041299677,
-0.03490838,
-0.011909201,
-0.014353329,
-0.012477918,
0.0066181035,
-0.018781196,
0.017860416,
-0.008686473,
-0.016479246,
0.001257609,
-0.013107569,
0.014028348,
0.0009436299,
-0.013107569,
-0.0122071,
0.013513795,
0.00045996666,
0.019674893,
0.010798849,
-0.007962036,
0.032498106,
0.007488105,
0.009275501,
0.009146863,
0.02362883,
-0.007752152,
0.026499497,
-0.01498975,
0.02654012,
0.02486105,
0.03750823,
0.044251587,
-0.029221212,
0.04308707,
-0.0039708624,
0.020893574,
0.00041045784,
0.006069698,
-0.013804924,
0.021353964,
-0.0060426164,
-0.016140725,
-0.01157745,
0.004756233,
0.008530753,
-0.012728425,
0.008720324,
0.0021682328,
0.027041132,
-0.007041256,
-0.028192105,
0.002423817,
-0.030087829,
0.025849534,
-0.0046716025,
-0.010670211,
0.014542902,
0.00972912,
0.021665404,
0.025375603,
0.0034410753,
-0.0052741715,
0.0057988805,
0.03599165,
0.027162999,
0.010731145,
0.0063506714,
0.023263227,
-0.030087829,
0.035233364,
0.0021699255,
-0.0006740818,
0.016086562,
0.001493728,
-0.0066045625,
0.0031296352,
-0.016695902,
0.022951785,
0.023073655,
-0.017846875,
0.010067642,
0.0102775255,
0.004075804,
-0.0151928635,
0.016411543,
-0.01235605,
0.007975576,
0.013168503,
0.0043635475,
0.038808152,
0.036641613,
0.041137185,
0.0057277908,
-0.0020040497,
-0.004289073,
0.01730524,
-0.017183373,
-0.0059309043,
-0.005179385,
-0.013561188,
-0.024820426,
-0.0054332768,
-0.011719629,
-0.014082512,
-0.017359404,
-0.0033225927,
0.030250318,
-0.015138701,
-0.009708809,
0.025592258,
0.0068042907,
-0.022504937,
-0.019065555,
0.025253735,
0.021597698,
-0.011679007,
0.015585549,
-0.029464949,
0.037941538,
-0.015233487,
0.015328272,
-0.0044075553,
0.002215626,
-0.017873958,
0.0029028256,
-0.00942445,
0.019011391,
0.019173881,
-0.0073120734,
0.017508354,
-0.0014784945,
-0.025131868,
-0.0129653895,
-0.015301191,
-0.030250318,
0.0051895413,
0.01035877,
-0.041570492,
-0.017711466,
-0.033256393,
-0.0032616588,
-0.0007565965,
-0.008246394,
0.02949203,
-0.003598488,
0.013507024,
-0.008083903,
-0.01696672,
0.0052098525,
0.027108835,
-0.018632246,
0.009072388,
-0.026445333,
0.00025283356,
0.008246394,
0.067921035,
0.009844217,
0.005233549,
0.026756773,
0.019688435,
-0.013507024,
-0.011164453,
-0.020216528,
0.030033665,
0.014299166,
0.01745419,
-0.042870417,
0.035612505,
-0.006611333,
0.016425084,
0.019891549,
-0.004800241,
-0.022491397,
0.0018754115,
-0.003386912,
-0.0028114247,
-0.003425842,
0.027704634,
0.04444116,
0.021272717,
0.01035877,
0.019024933,
0.02965452,
0.0000289066,
0.01157745,
-0.02533498,
-0.009932233,
-0.009891611,
0.016384462,
-0.01994571,
0.006773824,
0.007853708,
0.016316757,
0.021800812,
-0.010101494,
0.030683627,
-0.0037914456,
0.012714883,
-0.015247027,
0.012166478,
0.012166478,
-0.0024762878,
0.037020758,
-0.015504304,
-0.034177173,
0.03244394,
0.018212479,
-0.0055111367,
-0.012281575,
0.020013416,
-0.010697293,
0.0015783585,
-0.009641104,
0.0013464709,
-0.038672745,
-0.0299795,
-0.01249823,
0.008835422,
0.013141421,
-0.0005319026,
-0.0047054547,
-0.03707492,
0.000055697434,
0.000938552,
-0.023831943,
-0.0063303597,
-0.018645788,
-0.012416984,
0.022802837,
-0.00052682473,
0.015003292,
0.02965452,
-0.011218617,
-0.015368896,
-0.017102128,
0.013804924,
0.002770802,
0.016276134,
-0.014448116,
0.002879129,
0.011672236,
-0.018875983,
-0.021367503,
-0.011570679,
0.018957227,
0.0018364814,
-0.003615414,
0.02006758,
0.0115571385,
-0.006919388,
0.018144775,
0.018022908,
0.023723617,
-0.017928122,
-0.02392673,
0.019878007,
-0.04834093,
-0.00463098,
-0.028192105,
0.0017958588,
-0.0013168503,
-0.023141358,
-0.003490161,
0.0025473775,
-0.02641825,
0.015924072,
-0.045443185,
0.014312707,
-0.012423755,
-0.00417059,
-0.004150279,
-0.009119781,
0.009600482,
0.0265672,
-0.0009360131,
-0.014759555,
-0.002107299,
0.030331565,
-0.00020734468,
-0.036641613,
0.028923312,
-0.018781196,
-0.018293725,
-0.038808152,
-0.01651987,
-0.008300558,
0.03815819,
-0.003754208,
-0.025863076,
-0.021408126,
-0.0071902056,
-0.017047964,
0.00094955397,
0.003251503,
-0.010311378,
0.0055957674,
-0.024265252,
0.0014158679,
0.0059850677,
0.052565683,
-0.03192939,
-0.007366237,
0.015815744,
-0.012633638,
0.0025456848,
-0.0062186476,
-0.0034173788,
-0.0114555815,
0.0127351945,
-0.029248293,
-0.019200964,
-0.0006647724,
0.007704759,
0.023371553,
0.025781829,
0.028652495,
0.005155689,
-0.0015461989,
-0.00052682473,
-0.006117091,
-0.021543534,
-0.0042044423,
-0.0071292715,
0.011333714,
0.018930146,
0.012917996,
0.008842193,
-0.0036661925,
-0.018875983,
-0.0011010426,
0.013933563,
-0.0057853395,
-0.03999975,
-0.005233549,
-0.03569375,
-0.018334348,
-0.01742711,
-0.015057455,
0.01203784,
-0.042437106,
0.004928879,
0.011462352,
0.016249053,
0.012464377,
-0.0073865484,
0.012586245,
0.0059579858,
0.023994435,
-0.000633036,
-0.011780563,
0.0037575932,
-0.021096686,
-0.025551634,
-0.0026590896,
0.014285625,
-0.017075045,
0.023547584,
-0.0015817437,
-0.0110967485,
-0.013479943,
0.046418127,
-0.019498862,
0.0012305272,
-0.009451532,
-0.04555151,
0.010548343,
-0.0041198116,
-0.0077453814,
-0.004617439,
-0.012166478,
-0.0011086593,
-0.016032398,
0.041949637,
0.009708809,
-0.009031765,
-0.0036357255,
-0.004157049,
0.0030466972,
-0.026201596,
0.04276209,
-0.008848963,
-0.011794103,
-0.025917238,
0.03303974,
0.023669453,
0.013242978,
0.023249686,
0.028327515,
-0.018970769,
0.00610355,
-0.010913947,
0.015842825,
-0.039756015,
-0.031144017,
0.03490838,
0.018903064,
0.017251078,
-0.0048747156,
0.0042653764,
-0.019038472,
0.020040497,
0.0048577897,
-0.027894206,
0.0065063913,
-0.03490838,
-0.0066519557,
0.020893574,
-0.04414326,
-0.0071563534,
0.011638383,
-0.0085375225,
-0.00548067,
-0.017616682,
0.009505696,
0.008259935,
0.0024508988,
0.012525311,
0.011530057,
-0.00834118,
0.00417059,
0.002415354,
0.0056228493,
-0.004106271,
-0.0095734,
0.036885347,
-0.0012821518,
-0.02163832,
0.0086390795,
0.001127278,
0.008320869,
0.0069261584,
0.0009410909,
-0.01591053,
-0.009248419,
-0.022626806,
0.019160341,
0.0038489942,
-0.0528365,
-0.0024779805,
-0.00502028,
-0.0020412873,
-0.0068144463,
-0.027474439,
0.019079095,
-0.0051319925,
-0.014651229,
-0.009031765,
0.015477222,
0.041922554,
0.014691851,
-0.020514429,
-0.0071698944,
0.024062138,
-0.021800812,
0.036885347,
0.013669515,
0.010365541,
-0.029437866,
0.012708113,
-0.015558467,
-0.02008112,
0.013188814,
-0.014908506,
-0.030169073,
-0.0157345,
0.012870603,
0.021557076,
-0.0019820458,
-0.011679007,
0.0035172428,
0.007061567,
0.0033699858,
-0.028923312,
-0.020216528,
0.007048026,
-0.026986968,
0.023033032,
0.042843334,
-0.01806353,
0.011191535,
0.0015808974,
0.032037716,
0.002887592,
-0.022058088,
0.0063506714,
-0.016668819,
0.0058259624,
-0.022274742,
-0.0016655278,
-0.020852951,
-0.00010245578,
-0.0052098525,
0.013364846,
0.0151928635,
0.02487459,
-0.008774488,
-0.010392623,
-0.0019143415,
0.01745419,
0.004542964,
-0.0045158826,
-0.032173123,
0.0034309197,
-0.02253202,
-0.00320411,
-0.010087953,
0.048638828,
0.017115667,
-0.014353329,
-0.036045816,
-0.030196156,
-0.047636803,
-0.0054298914,
0.00074813346,
0.032362696,
-0.011611302,
0.0072375988,
0.016763605,
0.0077183,
0.017657304,
0.012423755,
-0.0149626685,
-0.024603773,
-0.0063303597,
-0.025402686,
0.0058191917,
-0.016181348,
-0.023872565,
0.009079158,
0.0299795,
0.018198939,
-0.015626172,
0.008490129,
0.01776563,
-0.013080487,
-0.0046411357,
-0.0060561574,
0.011374337,
-0.013974185,
0.013019553,
-0.029464949,
0.014299166,
0.0028029615,
0.0038693056,
-0.012139396,
-0.009282271,
-0.0010705756,
-0.0068313726,
-0.0030991682,
-0.012092003,
-0.028679578,
0.0024796731,
-0.019241586,
-0.004807011,
0.018916605,
-0.0015944382,
0.008632309,
0.02241015,
0.022504937,
-0.019173881,
0.014393952,
-0.014502279,
0.00013837083,
-0.008266705,
-0.032768924,
-0.012261264,
-0.013256518,
-0.015301191,
-0.021936221,
-0.032958493,
-0.0075896615,
-0.0067568976,
-0.007088649,
0.014813719,
0.011983676,
-0.0038185273,
0.005121837,
-0.010751456,
-0.0067433566,
-0.026743231,
-0.021827893,
-0.003723741,
-0.022369528,
0.01158422,
-0.0019786607,
-0.021665404,
-0.016357379,
-0.006760283,
-0.00077394577,
0.009776513,
0.034366746,
0.1960719,
-0.0024373578,
0.0036357255,
0.0022274742,
0.003229499,
0.019593649,
0.034041766,
0.0071292715,
0.0014768019,
0.030710708,
-0.0017290007,
-0.028219188,
-0.026160974,
0.01188212,
-0.021408126,
-0.008354721,
-0.028787903,
-0.006110321,
-0.010832702,
-0.012152937,
-0.00004826582,
-0.003390297,
0.015084537,
-0.008598457,
0.021990385,
-0.0012846907,
0.0054738997,
-0.007704759,
0.03211896,
-0.0056600864,
-0.010717604,
0.0039133136,
-0.005900437,
-0.016167806,
0.0021445365,
-0.0037745195,
-0.0015614324,
-0.0064149904,
0.012240953,
0.0013566266,
0.0069667813,
0.018659329,
0.010487409,
-0.008909897,
0.020852951,
0.027596308,
-0.00050016615,
-0.018388512,
-0.008909897,
0.0074204006,
-0.04958669,
-0.0038896168,
0.016005317,
0.033337638,
-0.0032633513,
0.00032371157,
0.0075828913,
0.0050405916,
-0.0108665535,
0.011286321,
-0.006452228,
0.011408188,
-0.016709441,
0.013757531,
-0.009214567,
0.029085804,
0.013608581,
-0.02316844,
-0.006865225,
-0.0129653895,
0.0022867157,
-0.011943053,
0.008903126,
-0.00068423746,
-0.018212479,
-0.032687675,
0.030087829,
0.0231549,
0.017007342,
0.043330807,
-0.011069667,
-0.0070209447,
-0.05974235,
0.027840042,
-0.027203621,
-0.045145284,
0.021543534,
0.0052403193,
-0.02284346,
-0.01173994,
0.008273476,
0.0057819546,
-0.014569984,
0.0116857765,
0.018930146,
0.031279426,
0.002787728,
-0.0063235895,
-0.02284346,
-0.010555114,
-0.034231335,
0.082816005,
-0.027840042,
0.00926873,
-0.008016199,
-0.0021106843,
0.011536827,
0.0015758196,
-0.006161099,
0.000061357096,
-0.006161099,
-0.031171098,
-0.004492186,
-0.023290308,
0.013845546,
0.027054671,
0.008070363,
0.009126551,
0.010060872,
-0.032416858,
0.008672931,
-0.02905872,
0.009058847,
0.015477222,
-0.006333745,
0.00070454873,
-0.016885474,
-0.020622756,
-0.023452798,
-0.010555114,
0.027054671,
-0.022735132,
0.015544927,
0.013642433,
-0.00082726293,
-0.0011585912,
-0.010467098,
-0.0044414075,
-0.0012466069,
0.013947103,
-0.0032735069,
-0.007704759,
0.0040622633,
0.0157345,
0.018036447,
0.014949128,
-0.0005534833,
0.0169938,
-0.00019041858,
-0.014569984,
-0.014028348,
0.00092331856,
0.019052014,
-0.005179385,
0.031198181,
-0.038212355,
-0.005199697,
-0.0017036116,
0.004448178,
-0.0051353774,
-0.027284866,
0.016425084,
0.019932171,
0.018049989,
-0.005264016,
0.0059647565,
-0.1720233,
0.009289041,
0.008977601,
-0.032254368,
0.004366933,
-0.015368896,
0.0041909013,
0.0058970517,
-0.0060426164,
0.008916668,
0.013750761,
-0.008246394,
-0.015341814,
-0.012640408,
0.014949128,
0.014732474,
-0.028598333,
0.020582132,
0.022640346,
0.011780563,
0.028679578,
-0.013920021,
0.013669515,
0.00037110466,
-0.004526038,
-0.00034635025,
-0.013019553,
0.0058293473,
-0.009309353,
-0.004830708,
-0.021448748,
-0.0027064828,
0.034014683,
-0.006885536,
-0.022857001,
-0.00911301,
-0.009566629,
-0.010913947,
0.008876045,
0.011130601,
0.033743866,
0.019810302,
0.0028537398,
0.0105077205,
-0.0012677646,
0.03661453,
0.03582916,
-0.018388512,
0.013121109,
0.016763605,
-0.0052030818,
0.0037609786,
0.030358646,
0.0039505507,
-0.017643763,
-0.018320806,
0.0035917177,
0.020202989,
0.0008784644,
-0.0077183,
-0.010751456,
-0.0122477235,
-0.0071631237,
-0.0062592705,
0.00023844637,
-0.02607973,
-0.0022020852,
0.002298564,
-0.009437991,
0.0015614324,
-0.0053689578,
0.00060891634,
0.012288346,
-0.027785879,
0.057413317,
0.018022908,
-0.011232157,
0.009302583,
0.01127278,
-0.010568654,
0.0019651197,
0.0054129655,
-0.024292333,
-0.024901673,
-0.004079189,
0.0044346373,
0.0011103519,
0.0023899649,
0.008070363,
-0.007041256,
-0.0005314794,
-0.043628704,
0.007982347,
-0.022396611,
0.01189566,
0.026580742,
0.0040893448,
-0.0037812898,
0.0050981403,
-0.0066519557,
0.016926097,
0.018618707,
-0.019999875,
0.0024255095,
0.02177373,
-0.0012804592,
-0.012227411,
0.011049355,
0.030710708,
-0.004556505,
0.002596463,
0.021909138,
0.03149608,
0.0032481179,
0.013486713,
0.035639588,
-0.003967477,
-0.019228045,
-0.003229499,
-0.0154230585,
0.04785346,
-0.00044134795,
-0.025754748,
0.004228139,
-0.020365478,
-0.007081879,
-0.11764314,
0.008104214,
-0.0012931537,
-0.0038388385,
0.010291066,
0.009776513,
-0.009708809,
0.0035409394,
-0.017413568,
0.024644395,
-0.004370318,
-0.022058088,
0.000899622,
-0.016140725,
0.027555684,
-0.037291575,
0.00818546,
-0.04804303,
-0.0076235137,
0.035179198,
-0.0012897685,
-0.012484688,
0.016005317,
-0.013351304,
-0.0011721322,
-0.00082430086,
-0.019823844,
0.02098836,
-0.0062186476,
0.005528063,
0.0006651956,
-0.008740636,
0.016465707,
0.010467098,
-0.00339876,
-0.032877248,
-0.013351304,
-0.02177373,
0.043249562,
-0.019688435,
0.0010528031,
-0.002557533,
0.0012322197,
-0.010717604,
0.020365478,
-0.02069046,
0.005436662,
0.015084537,
0.012674261,
-0.02377778,
-0.0053012534,
-0.019485323,
-0.028435841,
-0.018794738,
-0.003295511,
-0.017589599,
0.017075045,
0.00048577896,
0.0025084475,
0.0014429496,
-0.0027640315,
-0.011855038,
-0.024468364,
0.039620604,
0.017318781,
-0.012870603,
-0.024495447,
-0.0075964318,
-0.0046986844,
-0.0130940275,
-0.012342509,
-0.005264016,
-0.02098836,
0.003920084,
-0.05037206,
-0.013933563,
0.008760948,
-0.015179323,
0.005277557,
0.0054908255,
-0.010487409,
-0.0019041859,
0.026892181,
-0.04509112,
-0.005961371,
-0.00042801865,
0.02425171,
-0.00061187835,
0.011563909,
-0.01929575,
0.02654012,
0.03257935,
-0.004955961,
-0.013371616,
0.007968806,
-0.0016858391,
0.0014209457,
-0.0048611746,
-0.018185398,
0.028625414,
-0.0038252978,
0.0057481024,
-0.050426226,
0.013567959,
0.006824602,
-0.0027843427,
0.005528063,
-0.0041942867,
0.005585612,
0.00385915,
-0.008950519,
0.013845546,
-0.044386994,
0.03301266,
0.0034410753,
0.011177994,
-0.016452165,
-0.006161099,
0.016005317,
0.014272084,
0.01665528,
0.021584157,
-0.012552393,
0.0029231368,
0.0018838745,
0.003981018,
-0.010324919,
-0.005578841,
-0.0027369498,
0.03290433,
-0.0047494625,
0.0073459256,
-0.016885474,
-0.030358646,
-0.0050270506,
0.021692485,
0.01003379,
-0.018388512,
-0.00067281234,
0.025213113,
0.021205014,
0.026648445,
-0.00417059,
-0.020135283,
-0.0034867758,
-0.043466214,
-0.018022908,
0.00081710727,
-0.021814352,
0.010385852,
-0.0028825141,
0.0012779202,
0.02965452,
0.002862203,
0.0066485708,
-0.0038388385,
-0.015260568,
-0.010798849,
-0.002596463,
0.01714275,
0.00009007857,
-0.03320223,
0.02625576,
0.015098078,
0.015355354,
0.011726399,
0.018402051,
-0.012626868,
0.0061204764,
-0.0064285314,
-0.005633005,
-0.016601115,
-0.016953178,
0.0037812898,
0.010514491,
0.0066181035,
0.021421667,
-0.004983043,
-0.027447358,
0.009945774,
0.0044346373,
0.016249053,
0.03228145,
0.01497621,
-0.0336897,
0.032416858,
0.023439258,
0.011164453,
-0.018943686,
0.019485323,
-0.021570617,
-0.0030619309,
-0.013798154,
0.01791458,
0.0017120746,
0.0037135854,
0.005199697,
0.011814415,
-0.00042103665,
0.019173881,
0.025754748,
0.00926196,
0.006672267,
0.0026827862,
-0.02270805,
-0.030819036,
-0.004471875,
-0.0028706659,
-0.022680968,
-0.018957227,
-0.01929575,
0.03090028,
0.025348522,
0.011001962,
-0.0044244817,
-0.007887561,
-0.013933563,
-0.009647875,
-0.0033649078,
0.0071225013,
-0.01853746,
0.0029383702,
0.00024902518,
0.035558343,
-0.017088586,
0.013534106,
0.0057345615,
0.008693243,
0.0024424356,
-0.012999242,
0.0036221845,
-0.007041256,
0.026472414,
-0.02533498,
-0.042518355,
-0.0040047145,
0.0007066645,
-0.027758798,
0.02486105,
0.0050067394,
-0.0062051066,
0.070358396,
0.008104214,
-0.024143383,
0.008788029,
0.007840168,
0.0031854913,
-0.009749431,
0.0070209447,
0.0016866855,
-0.011482663,
-0.006919388,
-0.01637092,
0.008429196,
-0.018185398,
-0.01112383,
-0.00021400933,
0.0008920053,
0.014556442,
0.01637092,
-0.018943686,
0.008375033,
-0.008314098,
0.020148825,
-0.009018224,
-0.0125049995,
0.0046648323,
0.018009366,
-0.010778538,
-0.015653254,
-0.015639713,
-0.0010561884,
0.009119781,
-0.0265672,
-0.009952544,
0.013520566,
-0.018727032,
0.016127184,
-0.025145408,
-0.004380474,
0.0037779047,
0.007447482,
0.009065617,
-0.012559163,
-0.009390598,
-0.0084969,
-0.011638383,
0.0035917177,
-0.016411543,
-0.012240953
] |
US28 is one of four 7 transmembrane (7TM) chemokine receptors encoded by human cytomegalovirus and has been shown to both signal and endocytose in a ligand-independent, constitutively active manner. Here we show that the constitutive activity and constitutive endocytosis properties of US28 are separable entities in this viral chemokine receptor. We generated chimeric and mutant US28 proteins that were altered in either their constitutive endocytic (US28 Delta 300, US28 Delta 317, US28-NK1-ctail, and US28 | [
-0.01862602,
-0.015026144,
-0.01845269,
-0.015999444,
-0.008573035,
0.00049581606,
-0.018946007,
0.0010899621,
-0.0373587,
-0.0005303982,
0.022892537,
0.0041198567,
-0.0066531016,
0.008559702,
-0.01617277,
-0.0018549354,
0.011866254,
-0.007619735,
-0.019852642,
-0.009619665,
-0.026599074,
0.0031582233,
-0.011412936,
-0.031972222,
-0.0034015484,
0.01593278,
0.014466164,
-0.04861164,
-0.011612929,
-0.01854602,
-0.015226137,
0.0051098224,
-0.015066142,
-0.0003658206,
0.0036032079,
-0.0058764624,
0.014532828,
-0.009992986,
0.014199506,
0.006103121,
0.018732682,
0.023785839,
-0.007699732,
0.0039198636,
-0.0058164643,
-0.0020732612,
0.0029898959,
-0.030638933,
-0.010372972,
0.033492167,
0.0018882676,
0.007439741,
-0.011232942,
-0.0012224575,
-0.024585811,
-0.005319815,
0.0013666191,
-0.0043631815,
0.009686329,
-0.049864933,
-0.008913023,
-0.00072789134,
-0.027759034,
0.01705274,
-0.002823235,
0.0051898193,
-0.011706259,
0.011766258,
0.0049631605,
0.0144128315,
0.03215888,
0.013959514,
-0.0036365401,
-0.0029732299,
0.018799346,
-0.020159299,
-0.045198426,
-0.0149728125,
-0.021812575,
0.0028932327,
0.028852329,
-0.02485247,
-0.021812575,
0.027385714,
0.012672893,
0.0050498242,
0.023719175,
0.024732472,
0.008999687,
-0.005949793,
0.00469317,
0.01542613,
0.018706016,
0.02178591,
-0.02754571,
0.014919481,
0.0029015657,
0.039651953,
0.009019686,
-0.000527065,
-0.0026482411,
-0.0065864376,
-0.0031798894,
-0.024599144,
-0.016599422,
-0.0022932536,
-0.0009649664,
-0.038958646,
0.01398618,
-0.027105724,
-0.025439115,
0.022972533,
-0.01101295,
-0.027945694,
0.026692405,
0.008666365,
-0.00459984,
-0.0038365333,
-0.011552932,
-0.005996458,
-0.004079858,
0.02415916,
0.0060864547,
-0.017772716,
0.03818534,
0.030212281,
0.0033982152,
-0.011792923,
-0.019305995,
-0.0055298074,
0.015212804,
-0.006683101,
0.037465364,
0.023025865,
-0.021599248,
0.040505257,
-0.013972847,
0.014386166,
-0.01235957,
-0.022839205,
0.012526231,
0.03415881,
-0.0005733134,
0.013172875,
-0.0015666122,
0.0022515883,
0.029465642,
0.007319745,
0.011026283,
-0.009726328,
-0.002754904,
-0.021585915,
0.010046317,
0.0053731464,
0.021412589,
0.011939584,
-0.021732578,
0.026359083,
-0.01179959,
-0.023785839,
-0.023585847,
0.00012593312,
0.021759244,
-0.0146928225,
0.02374584,
0.028612338,
0.015399464,
0.010852955,
-0.007039755,
-0.014106176,
-0.0073664105,
0.014426164,
-0.0001677025,
0.013326203,
-0.0098196585,
0.012332904,
0.0039798617,
0.00556314,
-0.032185547,
-0.00044998433,
-0.009513003,
0.0258791,
0.023825837,
0.011372938,
-0.014826151,
0.0037065377,
0.021532584,
-0.0154661285,
0.0062764483,
-0.013099545,
-0.0019132667,
0.0026732404,
-0.0019815976,
-0.011319607,
-0.6331513,
-0.032212213,
0.01514614,
-0.01024631,
-0.021385923,
0.042585187,
0.03391882,
-0.017186068,
-0.0042231865,
0.01923933,
-0.03205222,
-0.00071705837,
-0.00060581224,
-0.017292732,
-0.030078953,
-0.022425886,
-0.032398872,
-0.0026032429,
0.030958923,
0.0061364532,
-0.02690573,
-0.008426374,
-0.015986111,
0.00499316,
0.01542613,
0.0068030967,
0.02602576,
-0.03165223,
-0.0033015518,
0.023145862,
-0.034185477,
0.016826082,
0.0037798686,
-0.019492656,
0.04175855,
0.007319745,
-0.022732543,
0.004106524,
0.008593034,
0.012252907,
-0.0061397864,
-0.005596472,
0.003723204,
0.007099753,
-0.024612477,
0.021319259,
0.0049298285,
0.007359744,
-0.004459845,
-0.012179576,
0.008793027,
-0.016906079,
-0.012866219,
0.0043965136,
-0.0045798407,
0.0012366236,
0.023572514,
-0.021999234,
0.027292384,
0.0058064647,
-0.00037269536,
0.02077261,
0.004953161,
-0.024052497,
0.0041631884,
-0.013879517,
-0.016306099,
-0.0064931074,
0.00013593277,
0.019985972,
0.019319328,
0.011999583,
0.006306447,
0.020065969,
0.009226345,
0.035412103,
0.018426025,
-0.0074330745,
0.008006388,
0.01331287,
0.012212909,
-0.0058164643,
-0.031118918,
0.012439568,
0.014279503,
0.0039898613,
-0.047891665,
0.01933266,
0.0027165723,
0.012139577,
-0.0042431857,
0.008533036,
-0.024345819,
-0.026799068,
-0.039225303,
0.013139543,
-0.0006562272,
0.028132355,
-0.0060831215,
-0.0030165617,
-0.010119648,
-0.027625706,
0.016746083,
-0.012406235,
0.027652372,
0.0011157945,
-0.038638655,
0.018799346,
0.06239783,
-0.032318875,
-0.0026299085,
-0.020665947,
-0.0015357799,
-0.01714607,
-0.0028599005,
-0.02546578,
0.023545848,
0.013019547,
0.0038665321,
-0.02215923,
0.0057098013,
-0.0053431476,
-0.002768237,
-0.01737273,
0.013232873,
0.009153015,
0.010966285,
-0.019479323,
-0.0064631086,
-0.004869831,
0.015719453,
0.007253081,
0.017999373,
-0.012366236,
0.034532133,
0.012186242,
0.0059397933,
0.015092808,
-0.010426304,
-0.014332835,
-0.030105619,
-0.006076455,
0.0026299085,
-0.011179611,
-0.012886219,
-0.011512932,
-0.0061097876,
-0.0043931804,
-0.0127662225,
-0.004246519,
0.0115329325,
-0.0059131277,
0.0074930727,
-0.0003889448,
0.03485212,
-0.015546125,
-0.0066597685,
-0.025065795,
0.0062964475,
-0.015172806,
-0.0030382276,
0.016839415,
-0.01398618,
0.007339745,
0.0005512308,
0.013972847,
0.014572826,
-0.0014057844,
-0.0009741328,
-0.037838683,
0.0016491093,
0.0046531716,
-0.013999513,
0.013599527,
0.0044731777,
0.019852642,
-0.0096063325,
-0.025892433,
-0.0021632581,
-0.009652997,
0.018439358,
0.0013641192,
-0.0044498453,
-0.0057331338,
0.03298552,
0.0046965033,
0.026745737,
0.008959688,
0.013759521,
0.018759347,
-0.004446512,
-0.018706016,
-0.006793097,
0.027652372,
0.021425921,
-0.010312974,
0.017452726,
0.01361286,
0.009373007,
0.018852677,
-0.0066631017,
-0.024332486,
-0.004109857,
-0.016306099,
0.013646192,
-0.020012638,
-0.010386305,
-0.020185964,
0.027252385,
0.010086316,
0.00023103363,
0.0073264115,
0.0075797364,
0.0032598865,
-0.0043798476,
0.013139543,
-0.015692787,
0.0016382764,
0.005213152,
-0.02155925,
-0.009759661,
-0.018146036,
0.013346203,
-0.008186382,
-0.0053431476,
0.033012185,
-0.00020572201,
0.017479392,
-0.008799694,
-0.017346064,
-0.01686608,
0.00001678327,
0.027359048,
0.02443915,
0.004936495,
0.0017182735,
0.013299537,
0.0032032218,
0.024559146,
-0.007439741,
0.0030548938,
0.00833971,
-0.000040779832,
0.0051098224,
0.0077197314,
-0.021439254,
0.0074864062,
0.012572896,
-0.0105263,
0.016066108,
-0.009433005,
0.011806256,
-0.0010357973,
0.0034998783,
-0.0061697853,
-0.0022199228,
-0.014812818,
0.024332486,
0.03258553,
0.022599213,
0.011399603,
-0.0008103885,
-0.018092703,
0.008906357,
0.021412589,
0.028985659,
-0.028319014,
-0.020945938,
-0.0048031663,
-0.0007883059,
-0.008459706,
-0.0071530845,
0.0015282802,
-0.017772716,
-0.008033054,
0.020759277,
0.009533002,
0.0029532306,
0.018999338,
0.020932605,
-0.010832956,
-0.017172735,
0.004633172,
0.017692719,
-0.014199506,
-0.011566265,
-0.022145895,
0.01080629,
-0.007913058,
-0.0011732925,
-0.029545639,
0.0057164677,
0.010479636,
0.0029715633,
-0.025585776,
-0.002746571,
0.035252105,
-0.033118848,
0.0017166069,
0.00075330713,
-0.004013194,
-0.0028315682,
-0.017532723,
-0.0074597406,
0.024479149,
0.015599458,
0.0005328981,
0.0011899587,
0.003049894,
-0.008393042,
-0.004799833,
0.0015107808,
-0.016932745,
-0.025599109,
-0.0070597543,
-0.00033123847,
-0.00919968,
-0.0022199228,
0.02991896,
-0.0078930585,
-0.014572826,
-0.03578542,
-0.005333148,
-0.006273115,
0.01467949,
0.018359361,
0.00966633,
0.012352903,
0.009113017,
-0.0017532724,
-0.017159402,
-0.0325322,
0.0046065063,
-0.004373181,
-0.033785492,
-0.010792958,
-0.01681275,
-0.010019652,
0.02625242,
0.021679245,
0.008346376,
-0.026879065,
0.020385958,
0.0023749173,
0.029332314,
-0.0034565465,
0.0018366028,
0.027705703,
0.015839448,
-0.011999583,
0.008613033,
0.031998888,
0.003573209,
-0.028932327,
0.012119578,
0.010932953,
-0.0077530635,
-0.0077930624,
-0.013379535,
-0.039385296,
-0.00631978,
0.023319189,
-0.0013432866,
0.015066142,
0.03015895,
0.008226381,
-0.004279851,
0.003143224,
-0.014066177,
-0.011866254,
-0.016906079,
0.010726294,
0.018359361,
-0.02049262,
0.044211794,
-0.030638933,
0.0032848858,
-0.012979548,
0.0076863994,
0.017439393,
0.0013782853,
0.004079858,
-0.0061097876,
-0.025452448,
-0.0015032811,
-0.021719245,
0.0076863994,
-0.004553175,
-0.0077063986,
-0.021665912,
-0.012092913,
-0.015452796,
0.0002009305,
-0.0069397585,
0.015772784,
-0.036932047,
-0.013972847,
0.0096063325,
0.010126314,
0.022145895,
-0.00010812124,
-0.0061764517,
0.011299606,
0.036185406,
-0.03999861,
-0.011412936,
-0.0100996485,
-0.02690573,
-0.0048798304,
0.001946599,
0.010632964,
-0.00747974,
-0.0101996455,
-0.008346376,
0.0019116001,
-0.026225755,
0.014732821,
-0.0035865419,
0.00516982,
0.013152876,
0.019399324,
-0.00021207596,
0.0050398246,
-0.004336516,
-0.0058397967,
-0.013626193,
0.00015176555,
-0.0154661285,
-0.0030948923,
-0.00680643,
0.010899621,
0.018986005,
-0.019345993,
-0.027652372,
-0.010979618,
-0.021999234,
-0.013252872,
-0.015186138,
0.0072064158,
0.0041831876,
-0.0067064334,
0.0008308044,
0.03029228,
-0.024519147,
-0.0026182423,
-0.03085226,
0.014826151,
0.002099927,
-0.010486302,
0.018172702,
0.010359639,
-0.023959167,
0.00011249608,
-0.009752994,
-0.020705946,
0.028639004,
-0.0017599388,
-0.009279677,
-0.016132772,
0.0011191277,
-0.005736467,
-0.0012691225,
0.0052831494,
-0.008113051,
-0.027759034,
0.008706364,
-0.01361286,
-0.00083122106,
-0.003786535,
-0.035945415,
-0.0018149369,
0.017799381,
-0.0051631536,
0.0032598865,
0.0049464945,
-0.0040598586,
-0.011359605,
-0.023225859,
-0.017106071,
-0.029812297,
-0.028985659,
0.025025796,
0.032318875,
0.020279294,
0.027119057,
-0.016412763,
0.034878787,
0.023105863,
0.018892676,
0.010932953,
0.0047865002,
0.031518903,
-0.020559285,
0.02114593,
0.018519355,
0.010932953,
0.0073064123,
-0.001954932,
0.010439637,
0.0072797467,
0.001292455,
-0.0040065274,
0.01015298,
-0.03994528,
-0.019252663,
0.0393053,
-0.022932535,
-0.0046665045,
-0.048931632,
-0.00497316,
0.0182127,
0.00029665633,
0.006596437,
-0.0068664276,
0.023945833,
-0.017599387,
0.018186035,
-0.017346064,
-0.010499635,
0.0000026480197,
0.005793132,
0.00011572514,
-0.0033698827,
0.028185686,
0.0034898785,
-0.004886497,
0.008219714,
0.023252524,
-0.004139856,
-0.0043631815,
-0.004016527,
-0.017506057,
-0.011446268,
-0.012279573,
-0.026305752,
-0.016906079,
-0.011419603,
-0.05626471,
-0.00019155584,
0.016346099,
-0.0034598797,
0.015026144,
-0.009486336,
-0.012686226,
0.03861199,
0.00796639,
0.018039372,
-0.0117129255,
0.030798929,
0.013732855,
0.0020382623,
-0.04661171,
-0.019599319,
0.004799833,
0.0036998712,
0.0315989,
0.030638933,
0.01273289,
-0.0036398734,
0.0034732125,
0.018052705,
-0.013919516,
-0.03690538,
0.027812365,
0.0032998852,
0.006396444,
-0.012972882,
-0.008179716,
-0.008473039,
0.04071858,
-0.015746119,
-0.0117129255,
-0.0013966181,
-0.0005691469,
-0.022879204,
0.04450512,
0.0013857852,
0.0201193,
-0.0024199157,
-0.0044365125,
0.005583139,
-0.0364254,
0.016946077,
0.0033632163,
-0.014399499,
0.013879517,
0.029545639,
-0.0037965346,
-0.006473108,
-0.00095246686,
-0.004726502,
-0.012492899,
-0.00998632,
0.03709204,
-0.0048098327,
0.012132911,
0.036318738,
-0.006183118,
0.016519425,
-0.010306308,
-0.0013957848,
-0.005546474,
-0.035838753,
-0.012646227,
0.013052879,
0.018759347,
-0.0027832366,
-0.011732925,
-0.009193013,
0.008439707,
-0.038212005,
-0.02619909,
0.017212734,
-0.03778535,
0.011772924,
-0.008373042,
0.0115329325,
0.039091974,
0.01579945,
0.0071997494,
-0.0023915835,
0.041198567,
-0.007846394,
0.013306203,
0.023159195,
-0.00026478246,
-0.032558866,
-0.01073296,
-0.002001597,
-0.026385749,
0.0021282593,
-0.010112981,
-0.012692892,
0.0033232176,
-0.024612477,
0.018026039,
0.024505815,
-0.01129294,
0.027519042,
-0.0023865837,
0.019292662,
0.010432971,
0.005649803,
0.029865628,
-0.047411684,
0.009999652,
0.02049262,
-0.0017116071,
-0.01303288,
-0.0033615497,
-0.01639943,
0.0011899587,
-0.01942599,
-0.018786013,
-0.018639352,
-0.0067064334,
-0.008719697,
-0.013052879,
-0.008226381,
-0.015732786,
-0.010799624,
0.02053262,
0.010012985,
-0.028399011,
-0.004189854,
-0.0044865105,
-0.008459706,
0.009646331,
-0.03935863,
0.004646505,
-0.0028765665,
-0.0073864097,
-0.013412867,
-0.0014591159,
-0.011646261,
0.017546056,
-0.0057597994,
-0.0071864165,
-0.028692335,
-0.017972708,
-0.054664765,
-0.014706155,
-0.0022465885,
-0.0020765944,
-0.009786326,
0.017812714,
-0.020425957,
-0.012246241,
-0.019079337,
0.013919516,
-0.016346099,
-0.0029732299,
0.04357182,
-0.01705274,
0.007039755,
0.036585394,
-0.019585986,
-0.000459984,
0.03786535,
0.0104129715,
-0.011812923,
0.033652164,
-0.018919341,
0.00708642,
0.0023232526,
0.011566265,
-0.0037598691,
0.009959654,
0.019452656,
-0.021119265,
-0.014519495,
-0.011286274,
0.009353008,
0.008666365,
0.010746293,
0.0058197975,
0.010492968,
-0.0003122808,
0.007746397,
-0.041731883,
0.009539668,
0.017972708,
0.02941231,
0.023292523,
0.0063531124,
-0.010812957,
0.011572931,
0.0095730005,
-0.014106176,
-0.002006597,
-0.005756466,
-0.0016949411,
0.00497316,
0.015452796,
-0.0041665216,
-0.0009724662,
-0.0020165965,
-0.008153049,
0.0063397796,
0.012046248,
0.008386374,
-0.03655873,
-0.0052498174,
0.0032132214,
-0.039278634,
-0.004509843,
0.010092982,
-0.014159507,
-0.018692683,
0.009126349,
-0.0005141488,
0.0029165652,
-0.013212874,
0.010166313,
-0.017572721,
-0.00078872254,
-0.021519251,
-0.009073018,
-0.0065131066,
0.004616506,
0.20340626,
-0.005456477,
0.016666086,
0.020759277,
-0.009113017,
-0.011052948,
0.018612687,
0.0072597475,
0.0009241345,
0.00075580704,
0.017466059,
0.013179542,
-0.005103156,
-0.0035532098,
0.0054998086,
0.012286239,
-0.040691916,
-0.032265544,
-0.021799242,
-0.0032782194,
-0.009639665,
-0.0067964303,
0.010319641,
-0.021719245,
0.023052532,
0.00031582234,
-0.038345333,
0.0008424707,
0.0058531296,
0.005199819,
-0.03335884,
-0.0036865384,
0.01073296,
0.01965265,
0.02002597,
0.011806256,
-0.009726328,
-0.0098196585,
0.003214888,
0.021505918,
-0.025865767,
0.011939584,
-0.015919447,
-0.0022732543,
-0.019012671,
0.019039338,
-0.0021665914,
-0.034212142,
0.0063531124,
0.011399603,
-0.02546578,
-0.0012916217,
-0.0050498242,
0.016426096,
-0.022505883,
-0.0060497895,
-0.004263185,
0.029012324,
-0.01198625,
0.026932396,
-0.009999652,
0.009073018,
-0.037145372,
0.017466059,
0.0011182944,
0.041785214,
-0.022145895,
0.009419672,
0.016226102,
-0.04962494,
-0.0016616088,
0.007439741,
-0.014506162,
0.005616471,
-0.006483108,
-0.0048564975,
-0.0022332557,
0.012739557,
0.041838545,
-0.000046508798,
0.0036432066,
0.0008858025,
-0.04061192,
0.003819867,
-0.0055164746,
-0.016092774,
0.025692439,
0.0056398036,
-0.006219784,
0.02161258,
0.005413145,
-0.0172794,
-0.008899691,
0.008886358,
-0.0050698235,
-0.006359779,
-0.005456477,
-0.013252872,
0.02527912,
0.006763098,
-0.040638585,
0.09338342,
0.039758615,
0.010946286,
-0.007813062,
0.0046965033,
0.0073130787,
-0.0034015484,
0.0067597646,
-0.026505744,
0.0032315543,
-0.021719245,
0.0026965728,
0.008053053,
0.0052164854,
0.019919308,
-0.005133155,
-0.01463949,
0.03317218,
0.010126314,
-0.00039873613,
-0.040265266,
-0.01979931,
0.016892746,
0.00085580355,
0.0106596295,
-0.020759277,
-0.0020649282,
0.018759347,
-0.036052078,
-0.0069997567,
0.012339571,
0.01198625,
0.004523176,
-0.0016932745,
-0.0039665285,
0.012572896,
-0.016919412,
-0.029572304,
0.020399291,
-0.005933127,
-0.01607944,
0.035812087,
-0.0012574563,
0.000699559,
-0.018799346,
0.026492411,
0.019292662,
-0.022572547,
-0.015199471,
0.0058897953,
-0.011839588,
0.00987299,
-0.0154661285,
0.019212665,
-0.0345588,
-0.028212352,
-0.034025483,
-0.005276483,
0.0031932222,
-0.020865941,
-0.015279468,
0.028319014,
-0.014999478,
-0.027145723,
-0.0037632023,
-0.16831414,
0.026545743,
-0.01061963,
0.000498316,
0.016652754,
0.013839519,
-0.0021665914,
0.023719175,
-0.005399812,
-0.018799346,
0.0488783,
-0.008999687,
-0.047118362,
-0.017319398,
-0.010652963,
-0.013446199,
-0.023425851,
0.024012499,
0.014146174,
-0.010159646,
0.05562473,
-0.03999861,
0.0030082287,
-0.0036032079,
0.0007816395,
0.024465816,
0.0059464597,
0.0035398768,
-0.0038431997,
-0.0039531956,
-0.021292593,
0.0056598033,
0.048398316,
-0.014346167,
0.0074930727,
0.007219749,
0.006859761,
0.0084863715,
0.009539668,
0.018146036,
0.015559459,
0.027625706,
-0.009826325,
0.009006353,
-0.028052358,
0.007319745,
0.0076130684,
0.016852748,
0.012339571,
-0.0021649248,
0.025172457,
-0.029012324,
0.034932118,
0.024345819,
0.04543842,
0.01955932,
-0.0023499182,
0.013166209,
0.009612999,
-0.00392653,
0.003224888,
-0.011212943,
0.019172667,
0.0019365993,
0.012172909,
-0.039971944,
-0.021492586,
0.008886358,
-0.034532133,
0.029465642,
-0.016932745,
-0.014746154,
-0.020785943,
-0.016572757,
0.013419533,
0.04130523,
-0.007159751,
0.015572792,
0.0077663963,
-0.009972987,
-0.015999444,
0.010752959,
-0.04330516,
-0.00910635,
-0.012959549,
-0.012992881,
-0.0067597646,
0.00488983,
0.011019616,
-0.0014516162,
-0.009553001,
-0.023359187,
0.022772541,
-0.018892676,
0.037012044,
0.016332764,
0.0040231934,
-0.012406235,
-0.0019332661,
-0.014812818,
0.025265787,
-0.0049664937,
-0.01714607,
0.01033964,
0.01542613,
-0.0067997635,
-0.011512932,
0.003893198,
0.039038643,
0.007866393,
-0.012912884,
-0.008146383,
0.004493177,
0.034265473,
0.0033748825,
0.0055698063,
-0.024319153,
0.004876497,
0.020612616,
-0.021039268,
0.04429179,
0.012459567,
-0.010726294,
0.003028228,
-0.0025115793,
-0.025932431,
-0.13983513,
-0.0109396195,
0.027332382,
0.012059581,
-0.012692892,
0.03015895,
-0.0027799034,
0.027812365,
-0.0036565394,
0.019106003,
-0.013179542,
-0.0051298216,
0.012199576,
0.000008821307,
0.009926321,
-0.0068464284,
0.024372485,
-0.017386062,
-0.018252699,
0.037145372,
-0.005413145,
-0.027812365,
0.013439532,
-0.013379535,
0.0070130895,
-0.012059581,
-0.018319363,
0.02713239,
0.008019721,
0.011259608,
0.021039268,
-0.009659664,
0.019385992,
0.010432971,
-0.019785978,
0.00026290753,
-0.0182127,
-0.013812853,
0.047545012,
-0.003376549,
0.0008391375,
-0.004373181,
-0.0075664036,
-0.0014891148,
0.006793097,
-0.010926287,
-0.005209819,
0.009006353,
-0.01514614,
-0.01649276,
-0.027839031,
-0.025532445,
-0.01983931,
-0.015026144,
0.010879622,
-0.016852748,
-0.006623103,
0.006853095,
-0.013452865,
0.0016941078,
0.012199576,
0.0042365193,
-0.027199054,
0.015866114,
0.028265683,
-0.0017732716,
-0.0017649386,
-0.015132807,
0.027145723,
-0.02903899,
0.012072913,
-0.0152528025,
0.0030798928,
-0.003616541,
-0.014186173,
-0.0017266066,
-0.0032598865,
-0.00526315,
-0.0032515535,
-0.009559668,
-0.017812714,
-0.011412936,
0.013346203,
-0.001856602,
0.0153328,
0.010459636,
0.010652963,
-0.0008316377,
0.014026179,
-0.028719,
-0.0070930864,
0.038265336,
0.010579632,
-0.015026144,
-0.00064914406,
0.016332764,
-0.020185964,
-0.01254623,
0.034372136,
0.02365251,
-0.020972604,
-0.017586054,
-0.0699709,
0.015719453,
0.0058897953,
0.0043798476,
0.021345925,
-0.035465434,
-0.013466198,
-0.01761272,
0.000087028224,
0.021892572,
-0.023679176,
0.010666296,
-0.010679629,
0.003773202,
-0.027679037,
-0.011019616,
0.042451855,
0.0040998575,
-0.006273115,
0.045758408,
-0.013692857,
-0.02485247,
-0.0033465503,
0.022892537,
-0.0013099544,
0.0025249121,
0.0021215929,
0.018012706,
0.00047248357,
0.018226033,
0.0109062875,
-0.027812365,
-0.0032998852,
0.00565647,
0.010672962,
-0.010312974,
-0.004893163,
0.015746119,
0.020879274,
0.02675907,
-0.013379535,
-0.039651953,
0.008646366,
0.0030982255,
0.003906531,
0.0016332765,
-0.023919167,
-0.007299746,
0.0032832192,
-0.004233186,
0.028745666,
0.016532758,
-0.008606367,
-0.025799103,
0.011579597,
0.005763133,
-0.010866289,
-0.023239192,
-0.0068864273,
-0.0016299433,
0.03543877,
0.0146928225,
0.0066031036,
0.017346064,
0.020852609,
0.010912954,
-0.04229186,
0.013379535,
-0.0000752578,
-0.024185825,
0.0015982777,
0.0064964406,
0.012839553,
0.000018788409,
-0.0059264605,
-0.008333043,
-0.0182127,
-0.005756466,
-0.012386235,
0.009772994,
0.016146105,
-0.0054231444,
-0.007253081,
0.0033582165,
0.0082730455,
-0.0007062254,
-0.009086351,
0.03317218,
0.0016574423,
-0.00315989,
0.0106596295,
0.023919167,
0.020945938,
-0.0023065864,
0.0018182701,
0.016599422,
0.0006837262,
0.010772958,
-0.005863129,
0.03917197,
-0.006456442,
0.009286343,
0.0063731116,
-0.025212456,
-0.0013324537,
0.022599213,
-0.042771846,
-0.03666539,
-0.024319153,
0.0146261575,
0.020972604,
-0.008353042,
0.019492656,
0.013259538,
0.0018932675,
-0.005736467,
0.0023265858,
0.0014099509,
-0.009026352,
0.0277857,
0.004583174,
0.018092703,
-0.010959619,
-0.013906183,
0.025399117,
0.01398618,
0.025545778,
-0.004049859,
0.020799275,
-0.009393007,
-0.0054331445,
0.0026565741,
-0.006119787,
-0.018146036,
-0.0048998296,
0.009859657,
-0.012086246,
-0.009399673,
0.007446408,
0.08917023,
0.035252105,
-0.013826186,
0.0019049337,
-0.019079337,
0.016146105,
0.023665844,
0.014306169,
-0.010479636,
-0.029118987,
0.013052879,
-0.0014241171,
0.03429214,
-0.043198496,
-0.014199506,
-0.004813166,
0.00947967,
0.0058497963,
0.0054464773,
-0.006149786,
-0.0058031315,
-0.030745598,
-0.019452656,
0.013826186,
-0.02230589,
0.00497316,
0.029758964,
-0.0073064123,
0.0031548901,
-0.04167855,
0.015506127,
0.01026631,
-0.04461178,
-0.011506266,
-0.01789271,
-0.015559459,
-0.024279155,
-0.02021263,
0.0044898437,
0.019492656,
0.011232942,
0.017106071,
-0.015172806,
-0.015719453,
0.029998956,
-0.013506196,
-0.035625428,
0.00651644,
-0.020665947
] |
Developmental signaling networks are composed of dozens of components whose interactions are very difficult to quantify in an embryo. Geometric reasoning enumerates a discrete hierarchy of phenotypic models with a few composite variables whose parameters may be defined by in vivo data. Vulval development in the nematode Caenorhabditis elegans is a classic model for the integration of two signaling pathways; induction by EGF and lateral signaling through Notch. Existing data for the relative probabilities of the three possible terminal cell types in diverse genetic backgrounds as well as timed ablation of the inductive signal favor one geometric model and suffice to fit most of its parameters. | [
-0.034195464,
0.009880358,
0.009293136,
-0.009395559,
-0.009545779,
0.0043836837,
-0.018750148,
-0.005937092,
-0.020921506,
-0.032556705,
0.012557001,
0.00618632,
-0.0076680323,
0.022451015,
-0.013226161,
0.010686083,
0.028487116,
0.014270871,
-0.0013289321,
0.03351265,
-0.0063706804,
0.014789811,
0.014694217,
-0.03692673,
-0.017753236,
0.034195464,
0.0041242135,
-0.03984919,
-0.0070671537,
0.0034499317,
0.008610319,
0.0034772444,
-0.0011582279,
-0.014680561,
-0.001464642,
0.013390037,
0.017794205,
-0.011245992,
0.008562522,
0.017043106,
0.012277045,
0.009286308,
-0.014489372,
-0.02053913,
-0.040122315,
-0.0008227942,
0.002275487,
-0.02739461,
-0.020743974,
0.016851919,
0.007831909,
0.027831612,
-0.028596366,
0.0009081463,
-0.018244864,
0.010972866,
0.0280228,
0.0073061395,
0.018258521,
-0.017944425,
-0.010010094,
0.016005225,
-0.02127657,
0.004793374,
-0.032829832,
0.013410522,
0.0023352334,
0.012126826,
-0.00691352,
0.001220535,
0.041897636,
0.032502078,
-0.0045475597,
-0.0043563712,
0.022478329,
0.020525472,
-0.020102127,
0.009211198,
-0.021686262,
0.00357796,
-0.007879705,
-0.028186677,
-0.010911413,
0.02933381,
0.02735364,
-0.005093813,
-0.0051074694,
0.020184064,
0.011123085,
-0.0034038415,
0.00219867,
0.016947512,
-0.0007788379,
0.0075041563,
0.0015636504,
-0.011676167,
0.0041720103,
0.026042633,
0.007538297,
-0.021262914,
-0.01334224,
0.022614893,
0.0012017576,
-0.01528144,
-0.003379943,
-0.013069113,
0.012987175,
0.007654376,
0.032147013,
-0.014352809,
-0.016155444,
0.029115308,
-0.0011172589,
-0.00902001,
0.021590667,
0.0003100415,
0.037746113,
0.017084075,
0.0017232589,
0.009491153,
0.017316233,
0.011341587,
0.018777462,
-0.0217682,
0.031327635,
0.032884456,
0.022341765,
0.00019524292,
-0.038456243,
-0.015977914,
0.003045363,
-0.0046158414,
-0.010849958,
0.02668448,
-0.028268615,
0.012140483,
-0.005175751,
-0.0029992727,
-0.003871571,
-0.009545779,
0.008637632,
0.016264696,
-0.022232514,
0.014134307,
-0.013669992,
0.009579919,
0.024308277,
0.020730317,
0.0093409335,
-0.009716483,
0.01289158,
0.004479278,
0.01896865,
-0.025073033,
0.00039155275,
0.028268615,
0.00038045697,
0.035615724,
0.01240678,
-0.0012111462,
-0.007545125,
0.0056195823,
-0.010133001,
0.01024908,
0.014844437,
0.022724142,
0.015882319,
-0.007879705,
0.008542038,
-0.0019426137,
-0.028596366,
0.028705617,
-0.015745755,
0.023857618,
-0.029934688,
-0.006998872,
0.010699739,
0.0052303765,
-0.025400784,
-0.018285833,
-0.0002549894,
0.011211852,
0.0035745457,
0.006783785,
-0.0114098685,
-0.011833215,
0.025510035,
-0.01099335,
-0.006585768,
-0.015117563,
-0.0052133063,
0.015786724,
0.0023437685,
-0.0015721857,
-0.636276,
-0.012673079,
0.016483197,
-0.026561573,
0.010310533,
0.016701698,
-0.0021320954,
-0.01222242,
-0.019323714,
0.017507423,
-0.029361121,
0.005158681,
-0.0067018466,
-0.002604946,
-0.03220164,
-0.03078138,
-0.007538297,
-0.030153189,
0.03089063,
0.025837786,
-0.025591973,
-0.0217682,
-0.00782508,
0.017384516,
0.0075041563,
0.014885406,
0.017015794,
-0.008917587,
0.0072105452,
0.02448581,
-0.010310533,
-0.0022567094,
-0.020566441,
0.009777936,
0.04755136,
-0.004185667,
-0.019992875,
0.037554923,
0.020703005,
0.03938487,
-0.041788388,
-0.006466275,
0.027626766,
0.00868543,
-0.054133713,
0.005288416,
0.011949293,
-0.002318163,
-0.0026305516,
-0.029115308,
0.005954162,
-0.0067428155,
-0.031791948,
0.010576832,
0.015895974,
-0.019419309,
0.013895322,
-0.02765408,
-0.006524314,
-0.009115604,
-0.00008471196,
-0.009750623,
-0.021440446,
-0.024868187,
0.00089278293,
0.027831612,
-0.028869493,
-0.0022857292,
-0.004161768,
0.0016737547,
0.022109607,
0.026848355,
0.016196415,
0.011587401,
0.012905237,
0.039931126,
0.011136741,
0.009450184,
0.0064116498,
0.023024581,
0.00009762146,
-0.020470846,
-0.0338404,
0.030207815,
0.03293908,
-0.02664351,
-0.021112695,
0.023652773,
0.0045748726,
0.011484978,
0.019159839,
0.010010094,
-0.013977259,
-0.037363734,
-0.006135109,
0.03222895,
0.003262157,
0.020989787,
0.007845565,
-0.04140601,
-0.023652773,
-0.030972568,
0.0027380954,
-0.012625283,
-0.001689118,
0.004363199,
-0.013683648,
0.0082415985,
0.040969007,
-0.025291534,
-0.013246645,
0.0010267857,
-0.009095119,
-0.011840043,
-0.0094297,
-0.02500475,
0.0056195823,
0.011102601,
0.007866049,
-0.023557179,
0.0009849631,
-0.012106341,
0.015254127,
0.0007331745,
0.010904584,
0.011307446,
-0.012864268,
-0.002772236,
-0.016551478,
0.0063023986,
-0.02172723,
-0.016087163,
0.00853521,
-0.016592449,
-0.0016029124,
0.0019033517,
0.026670823,
-0.002639087,
-0.01646954,
-0.02519594,
-0.014639592,
-0.011184539,
-0.0013477096,
-0.007094466,
-0.007203717,
-0.019883625,
-0.016169101,
0.016046194,
0.01214731,
-0.000005887961,
0.010044235,
-0.0026066531,
-0.014803467,
-0.0067462297,
0.005131368,
0.001913594,
-0.01196295,
-0.015882319,
0.013164707,
-0.008391818,
0.0064560324,
0.016715355,
-0.024403872,
-0.0049435934,
-0.008016269,
-0.0020074814,
-0.007886534,
0.0015064646,
0.016988482,
-0.0077841114,
0.0031853402,
-0.017712267,
-0.014475715,
0.024991093,
0.0000066714665,
0.01065877,
0.005011875,
-0.019965563,
-0.008692258,
-0.01565016,
0.0118537,
-0.03108182,
-0.02060741,
-0.01002375,
0.052904643,
0.014803467,
0.048835054,
0.029825436,
0.0188594,
0.016606104,
-0.0021730645,
0.0054659485,
-0.030754067,
0.01621007,
-0.01405237,
-0.025837786,
0.04572141,
0.010351502,
-0.0060361004,
0.051784825,
0.01743914,
-0.005582027,
0.005168923,
0.008774196,
-0.0008799801,
-0.0063023986,
0.0037213515,
-0.021850137,
0.00023813236,
0.012700392,
0.010235423,
0.019405654,
-0.011621541,
-0.0071081226,
0.02433559,
0.015595535,
-0.0217682,
0.01937834,
-0.009224854,
-0.026930293,
0.012058544,
-0.026575228,
0.027872581,
0.0128506115,
-0.0028780727,
0.015199501,
-0.011245992,
0.018722836,
-0.004438309,
-0.008139176,
-0.0038613288,
0.011819558,
-0.020552784,
-0.0026134811,
0.0060463427,
-0.005093813,
-0.008862962,
-0.014776155,
0.029579623,
0.006213633,
0.0069886297,
0.024199026,
0.011205023,
0.014134307,
0.025510035,
-0.0010575125,
0.032174326,
0.011457666,
-0.033731148,
0.0028627093,
-0.004847999,
0.024417527,
-0.01707042,
-0.008009441,
0.013588054,
-0.010453925,
0.009293136,
0.00019001511,
0.045339033,
0.01646954,
0.006135109,
-0.001829949,
-0.008630804,
-0.010078375,
-0.0052303765,
0.0011275013,
-0.008214286,
-0.00041587808,
-0.019323714,
-0.006271672,
-0.0034021346,
-0.0005539351,
0.0028592953,
-0.007292483,
0.0032723993,
-0.011007006,
0.0103993,
0.012024404,
0.009600404,
0.019774374,
0.008699086,
-0.0217682,
0.031245695,
0.029415747,
-0.01804002,
-0.01539069,
-0.013041801,
0.00060002523,
0.007606579,
-0.0047011934,
0.011682995,
0.0043358863,
-0.017999051,
0.0004621816,
-0.005206478,
0.022915332,
-0.0069613173,
-0.01024908,
-0.011293789,
0.0022089123,
0.015267783,
0.0064901733,
-0.01881843,
-0.0072310297,
0.037582237,
-0.0071081226,
-0.012236076,
-0.01646954,
0.005418151,
-0.012181452,
-0.012051716,
-0.011621541,
-0.0013733152,
-0.042908207,
0.0055137454,
-0.009163401,
-0.008064066,
-0.0054318076,
0.042689703,
0.0002927577,
-0.0005799675,
-0.03056288,
-0.0015738927,
-0.019091558,
0.020634724,
0.027217077,
0.013239818,
0.024704311,
-0.013581226,
-0.036243916,
-0.019473935,
-0.011362071,
0.014844437,
-0.0047285063,
0.004568044,
0.0027807713,
0.012789158,
0.010849958,
-0.00018734785,
0.022191545,
-0.0053942525,
-0.020129438,
-0.0035643035,
-0.0034157909,
-0.008692258,
-0.02105807,
0.019050589,
0.032884456,
0.003219481,
0.008303052,
0.02228714,
0.019774374,
-0.004352957,
-0.012584313,
-0.0043222304,
0.012181452,
0.0042607766,
0.029006056,
0.000074042946,
-0.0051928214,
-0.0034909009,
0.02515497,
-0.00868543,
-0.0035165064,
0.016005225,
0.008439615,
0.0031511993,
-0.015431659,
-0.016851919,
-0.0047831316,
-0.0034123769,
-0.004032033,
-0.017425485,
-0.0060019596,
0.019159839,
-0.016373945,
0.0040183766,
-0.03946681,
0.007039841,
0.002202084,
-0.00025392248,
-0.013943119,
0.004708022,
-0.026192851,
-0.0019733405,
-0.0064184777,
0.020812256,
-0.022928987,
-0.0012495547,
-0.011273305,
-0.015486284,
0.000391126,
-0.022969956,
-0.022341765,
0.0028695376,
-0.038456243,
-0.022751454,
-0.02351621,
0.018053675,
0.043235958,
0.031791948,
0.006220461,
0.003827188,
0.019310059,
-0.0040798304,
-0.022669517,
-0.01457131,
-0.016565135,
0.0036769684,
0.013103254,
0.0046090134,
-0.005855154,
-0.009573091,
-0.002202084,
0.015185845,
-0.0014415969,
0.0064901733,
-0.014352809,
-0.012741361,
0.006592596,
0.008098207,
0.016332977,
0.015103907,
-0.006230703,
-0.008651288,
-0.019801687,
-0.015213158,
-0.036981355,
-0.01240678,
-0.00764072,
-0.0025315431,
0.0048343427,
-0.029907376,
-0.0018265349,
-0.002768822,
-0.017220639,
-0.007770455,
0.018121958,
0.0028234473,
0.019432966,
0.023393303,
0.0049060388,
-0.00022447601,
-0.010010094,
0.009545779,
0.016169101,
0.011703479,
0.0069408324,
-0.051320508,
0.035806913,
-0.01918715,
-0.0024939883,
-0.027817955,
0.012645767,
0.0014176983,
0.047496736,
0.014694217,
-0.019992875,
-0.0013118617,
0.007886534,
-0.011164054,
0.010153485,
-0.014147963,
-0.02444484,
0.021645293,
0.006633565,
0.010645114,
-0.025960693,
0.013294443,
-0.039685313,
-0.012645767,
0.009552606,
-0.006992044,
0.007920675,
-0.0009542364,
0.0047353343,
-0.0042880895,
-0.023243083,
-0.011232336,
-0.04714167,
-0.012174623,
-0.001913594,
0.02306555,
0.03416815,
0.023611804,
-0.001870918,
0.025796818,
0.02351621,
0.0048172725,
0.017548392,
0.0051416103,
0.020621067,
-0.039494123,
0.031873886,
0.0011667631,
0.00423005,
0.004854827,
0.011088944,
0.027053202,
0.026397696,
0.0005142464,
-0.021180976,
0.0020689347,
-0.04378221,
-0.016073506,
0.023789337,
-0.0033901853,
0.0036189288,
-0.030071251,
0.014243558,
0.011621541,
0.016592449,
-0.024731623,
-0.020279659,
0.01121868,
-0.025701223,
0.031955827,
-0.025291534,
0.026042633,
-0.016182758,
-0.011232336,
-0.014147963,
-0.007647548,
-0.0018794532,
-0.011792245,
0.025605628,
0.00667112,
0.004434895,
-0.00086333643,
-0.01732989,
-0.003659898,
-0.016005225,
-0.0070125284,
-0.014926375,
-0.0056776213,
-0.025810475,
-0.01069291,
-0.02116732,
0.0032502078,
-0.0006956196,
-0.01918715,
0.004595357,
-0.011525948,
-0.025646599,
0.026465978,
-0.005817599,
0.02306555,
-0.021221945,
0.040258877,
0.021740885,
0.014612279,
-0.019446623,
-0.01672901,
-0.011669339,
0.013041801,
0.0336219,
0.0042129797,
-0.008521553,
-0.013874837,
0.020416223,
0.015336065,
-0.02578316,
-0.023762023,
0.018422397,
0.0013280787,
0.0070671537,
-0.012502375,
0.000999473,
-0.009491153,
0.007026185,
-0.010754365,
0.007606579,
-0.008262083,
-0.004342715,
-0.005807357,
0.026015319,
-0.010146657,
0.03916637,
-0.0014902477,
-0.008951728,
0.010972866,
-0.020511815,
-0.011867356,
0.017480109,
0.01188784,
0.020429878,
-0.002396687,
0.015732098,
0.025400784,
0.026547916,
0.004431481,
0.00039475344,
-0.018094644,
0.044082653,
-0.0040866584,
-0.017507423,
0.012802814,
-0.01285744,
0.018900368,
0.0020262587,
-0.0027910136,
-0.028596366,
-0.036571667,
-0.017521078,
0.01989728,
-0.0009909378,
0.019064244,
0.0034874866,
-0.010303705,
0.005578613,
-0.03231089,
-0.03181926,
0.005486433,
-0.03455053,
-0.009716483,
0.00066574634,
0.0027500445,
0.029880062,
0.0067018466,
-0.007326624,
-0.003134129,
0.028978745,
-0.01017397,
0.020880537,
0.016892888,
0.008111863,
-0.032338202,
0.007886534,
-0.008760539,
-0.032474767,
0.021440446,
-0.030043937,
-0.03569766,
0.011375727,
0.009573091,
0.016059851,
0.005745903,
-0.022328109,
0.013485631,
0.0035506473,
0.01672901,
-0.026315758,
-0.00058295485,
0.0071764044,
-0.002277194,
-0.00039027247,
0.004854827,
-0.00219867,
0.016428571,
-0.0072719986,
-0.0083986465,
-0.009607232,
-0.023748368,
-0.010296877,
-0.010631457,
0.015349722,
-0.0025417854,
-0.007982128,
-0.013874837,
-0.017316233,
-0.012304358,
0.024663342,
-0.0011257941,
-0.024431184,
0.008098207,
-0.014639592,
0.007695345,
0.020593753,
0.0015098786,
-0.019323714,
-0.0019426137,
-0.034195464,
-0.033184897,
-0.005530816,
-0.027490204,
0.029251872,
0.032119703,
-0.017862488,
-0.011901496,
-0.012775502,
-0.022123264,
-0.027681392,
0.0011351829,
-0.017343545,
-0.0018794532,
0.002278901,
-0.0045646303,
0.02433559,
-0.015185845,
0.012563828,
0.007531469,
0.01732989,
0.006712089,
-0.021495072,
0.016005225,
0.00036530697,
-0.0169202,
-0.019624155,
0.040095,
-0.025400784,
-0.03345802,
0.0023027996,
-0.014352809,
0.016073506,
-0.017384516,
-0.007982128,
0.0036701402,
0.011983435,
0.016264696,
-0.018504335,
-0.013021316,
-0.006298985,
-0.019105213,
-0.009013182,
-0.013164707,
-0.014584966,
0.011655683,
0.0054693623,
-0.035861537,
-0.020935163,
0.010337846,
0.00019748342,
0.017493766,
0.014748842,
-0.0057493174,
0.022587579,
0.02403515,
0.011860527,
-0.01963781,
-0.006722331,
-0.020334283,
0.012399953,
0.00069988717,
-0.012912065,
-0.010358331,
-0.017835174,
-0.008111863,
-0.04632229,
-0.0027107827,
-0.02030697,
0.0007173844,
-0.025769506,
0.029880062,
0.014284527,
0.005332799,
0.00398765,
0.0004852267,
0.00035975908,
-0.023243083,
-0.016264696,
0.0021030756,
-0.012734533,
0.0017232589,
-0.010344674,
-0.007476844,
0.006029272,
-0.014748842,
-0.0023932727,
-0.021194633,
-0.001710456,
0.1683553,
0.0065311426,
0.0050562583,
0.029962,
0.007736314,
-0.011041148,
0.02612457,
0.00016366264,
0.01017397,
0.006510658,
-0.004479278,
0.01621007,
-0.018763805,
0.0030709684,
0.035615724,
-0.03790999,
0.005858568,
-0.017275264,
-0.022259828,
-0.0068588946,
0.007743142,
-0.017794205,
0.005407909,
-0.019146182,
0.03823774,
0.007934331,
-0.026670823,
0.008917587,
0.008098207,
0.0015201209,
-0.015267783,
0.006756472,
0.010665598,
0.01319202,
0.01121868,
-0.008132348,
0.005336213,
-0.0024956954,
0.008617148,
0.02172723,
0.016783636,
-0.0042471206,
0.011969778,
-0.012167795,
0.018995963,
0.015404346,
0.00620339,
-0.017575704,
-0.0050323596,
-0.0074973283,
-0.04416459,
0.034523215,
0.0027227318,
0.018886711,
0.0024598474,
-0.000053211697,
-0.0051347823,
-0.0023915658,
0.0013494167,
0.03714523,
-0.032447454,
0.009238511,
-0.005762974,
0.0075109843,
-0.0036496557,
0.012481891,
-0.015472628,
0.0069852155,
0.012618454,
-0.01155326,
-0.0074905,
-0.019391997,
-0.02590607,
0.01584135,
-0.037554923,
-0.022642205,
0.0188594,
0.007572438,
0.021686262,
0.021904763,
-0.0018811602,
0.011573744,
-0.026370384,
0.0033338529,
-0.012277045,
-0.0072310297,
0.06522266,
0.0023437685,
-0.028050113,
0.006268258,
0.0058517396,
-0.007736314,
-0.010774849,
0.004960664,
0.0067530577,
0.0015388983,
-0.010563175,
0.005500089,
0.005954162,
0.013765587,
-0.022532953,
0.08068163,
0.026616197,
0.016278353,
-0.012092685,
0.01565016,
-0.002724439,
0.00946384,
0.013717789,
-0.017220639,
-0.009573091,
-0.007647548,
0.010870443,
-0.01121868,
0.004021791,
0.0050665005,
0.012714049,
-0.020703005,
0.027736017,
-0.005093813,
-0.019432966,
-0.036954045,
-0.016373945,
0.029524997,
-0.01024908,
-0.0144347465,
-0.013198848,
-0.013014488,
0.0035916162,
-0.010310533,
0.016155444,
-0.020730317,
0.0023898587,
0.015718441,
0.014079682,
-0.043891463,
0.0017616673,
-0.014543997,
-0.031655386,
0.014120651,
-0.01769861,
0.002444484,
0.02474528,
-0.0003390612,
0.009791592,
-0.011280133,
0.021454103,
0.022833394,
-0.025428098,
-0.023133833,
-0.0025878756,
-0.015336065,
0.018231208,
-0.012242905,
0.021481415,
-0.035724975,
-0.01334224,
-0.015527254,
0.028077425,
-0.016701698,
-0.025687568,
-0.00091241393,
0.014407434,
-0.01386118,
0.000075536605,
-0.0075587817,
-0.17327158,
0.013656336,
0.008951728,
-0.013410522,
0.010228596,
0.014516684,
0.004038861,
0.0067428155,
-0.02776333,
0.0084601,
0.027899893,
0.0012640646,
-0.04386415,
-0.041187506,
0.011232336,
0.02075763,
-0.010488066,
0.026370384,
0.0041344557,
0.023434272,
0.033376083,
-0.03130032,
0.022041326,
0.015458972,
0.004028619,
0.017999051,
0.017247953,
-0.0022601236,
-0.0016609518,
-0.026657168,
-0.019774374,
0.00009570104,
0.019391997,
0.0017164306,
0.004636326,
0.003419205,
-0.005496675,
0.000976428,
-0.023898587,
0.009989609,
0.014462059,
0.03446859,
-0.0027773574,
-0.00017657215,
-0.011826387,
0.013786071,
-0.0010933604,
0.0022464672,
0.018900368,
-0.027899893,
0.018586272,
-0.0051484383,
-0.002232811,
-0.0034431035,
0.026547916,
0.011532775,
-0.0036121008,
0.025045719,
0.0066574635,
-0.026984919,
0.010542691,
-0.013349068,
0.020320628,
0.012201936,
0.0018197068,
-0.006845238,
-0.03679017,
0.0006405675,
-0.049435936,
-0.0030470698,
0.007845565,
-0.015663818,
-0.00049333513,
-0.03252939,
0.037254483,
0.021399477,
-0.01784883,
0.010590488,
-0.008419131,
-0.0055410583,
0.008583006,
0.015226814,
0.00011330491,
-0.019815343,
-0.0059302635,
-0.014530341,
0.012290702,
0.022683173,
0.015035626,
-0.0055478862,
0.00976428,
-0.026069945,
0.032556705,
-0.025632942,
0.023270397,
0.018654555,
0.012106341,
-0.009265823,
0.013813383,
-0.0046226694,
0.03056288,
-0.0041685966,
-0.0034891937,
0.025591973,
0.014339153,
-0.0017992222,
-0.020225033,
0.0074017337,
0.05246764,
0.012748189,
-0.0144210905,
-0.0025844616,
0.00050784496,
0.0071354355,
-0.010406128,
0.035451848,
-0.01676998,
0.019351028,
0.002275487,
-0.012686736,
0.073744215,
0.014817124,
0.0010481237,
0.013062285,
0.0012000505,
-0.038702056,
-0.14016862,
-0.012953035,
0.0047558188,
0.023338677,
-0.015240471,
0.011560088,
-0.0067428155,
0.02862368,
-0.02243736,
0.043836836,
-0.042990144,
-0.019036932,
-0.0069340044,
-0.013772414,
0.00905415,
0.0029258698,
0.015295096,
-0.009231683,
-0.010283221,
0.04468353,
-0.017206984,
-0.021891106,
0.00042846752,
0.016551478,
-0.0041822526,
0.009416044,
-0.017125044,
-0.012119998,
0.0021269743,
0.008132348,
0.012461406,
-0.013758758,
0.028350553,
-0.019951906,
-0.03089063,
-0.024158057,
0.0058107707,
-0.020279659,
0.011833215,
-0.0041412837,
0.009832562,
-0.00382036,
0.01978803,
0.008965384,
-0.008344021,
0.0021252672,
-0.0016763152,
0.0200475,
-0.0014774448,
-0.00519965,
-0.028268615,
-0.030043937,
-0.019979218,
0.00830988,
0.016196415,
-0.011607885,
-0.0048070303,
-0.002721025,
0.005527402,
0.012488719,
-0.011034319,
0.010296877,
-0.025646599,
-0.010720223,
0.031983137,
-0.011075288,
-0.04509322,
-0.018463366,
0.013717789,
-0.017507423,
0.005544472,
0.009989609,
0.0022140334,
0.008507897,
-0.03487828,
0.0054625343,
-0.01528144,
-0.0045646303,
-0.0041822526,
-0.009586748,
0.0017343546,
-0.02209595,
0.039603375,
-0.00350285,
0.024103433,
0.037281796,
0.013212505,
-0.025428098,
0.007033013,
-0.014462059,
-0.009197542,
0.025605628,
0.0095116375,
-0.026971262,
-0.007278827,
-0.009074635,
0.010474409,
-0.02202767,
0.01687923,
0.023161145,
-0.04069588,
-0.00040840977,
-0.03681748,
0.021590667,
-0.012727705,
-0.026821043,
0.007579266,
-0.024321934,
-0.006196562,
-0.013198848,
-0.008193801,
0.021071726,
-0.0027159038,
0.013997744,
-0.02105807,
-0.012912065,
-0.024253651,
-0.043891463,
0.030699443,
-0.018914025,
0.027258046,
0.031464197,
0.017521078,
-0.016838262,
0.029825436,
0.019815343,
-0.013963603,
-0.026452322,
-0.02772236,
-0.015554566,
-0.004950422,
-0.0011957829,
0.025933381,
-0.034086213,
0.006766714,
0.010344674,
-0.014229902,
-0.015308752,
-0.0057254187,
0.032993708,
0.034441277,
0.042361952,
-0.013164707,
-0.023434272,
-0.0044587934,
-0.019310059,
-0.017603017,
0.0013588053,
-0.030071251,
-0.0032741064,
0.006316055,
0.012420437,
0.038592804,
0.0028729516,
-0.010208111,
-0.02157701,
-0.010385643,
-0.013178363,
-0.008992697,
0.0069374186,
-0.0079753,
-0.018231208,
0.022560267,
0.0051108836,
0.013697305,
0.0021064898,
-0.015035626,
-0.027708706,
-0.026247477,
0.020074813,
0.011341587,
-0.02955231,
-0.03089063,
-0.014885406,
0.013984088,
0.0070534972,
-0.010133001,
-0.014899062,
0.0020040672,
-0.010447097,
-0.016018882,
0.033976965,
0.01214731,
0.0079753,
0.0011095772,
0.01147815,
0.015295096,
0.01565016,
-0.019501247,
0.006548213,
0.0014313547,
-0.006432134,
-0.0045373174,
0.03078138,
0.0046499823,
0.011280133,
-0.005380596,
0.019555872,
0.020143095,
0.016537823,
0.010010094,
0.0032741064,
0.0037964613,
0.011198195,
0.03293908,
-0.030426316,
0.01382704,
0.020730317,
-0.029579623,
-0.027326327,
-0.0014774448,
0.012358984,
-0.015595535,
-0.009921328,
0.005052844,
-0.0024120503,
-0.009047322,
0.025114002,
-0.004103729,
-0.006916934,
-0.024130745,
0.016851919,
0.023611804,
0.012864268,
-0.00715592,
-0.013581226,
0.01763033,
-0.0021952558,
0.021358509,
-0.012092685,
0.023270397,
-0.010406128,
0.0055513005,
-0.012454578,
0.010262736,
-0.00036359995,
-0.0006708675,
-0.009258996,
-0.0023062136,
-0.003936439,
-0.034004275,
0.09275383,
0.012557001,
-0.003581374,
0.024321934,
-0.035451848,
0.0316827,
-0.0018896954,
0.027258046,
-0.0019084729,
-0.04080513,
0.025182283,
-0.021645293,
0.0011240871,
-0.014899062,
-0.005865396,
0.008651288,
-0.021891106,
0.014748842,
-0.020853225,
-0.0147351865,
0.005605926,
-0.009450184,
-0.0005859421,
0.028405178,
-0.007196889,
0.0008953435,
0.010911413,
0.021536041,
-0.00853521,
-0.006100968,
0.0047353343,
0.009607232,
-0.040095,
-0.00038003022,
-0.031027194,
0.00077158294,
-0.004066174,
-0.02351621,
0.00018852144,
0.023202114,
-0.0050733285,
-0.00028934362,
-0.023939556,
-0.03908443,
-0.009047322,
0.0030385347,
-0.015322409,
-0.015513597,
-0.019391997
] |
The morphogenesis of the C. elegans embryo is largely controlled by the development of the epidermis, also known as the hypodermis, a single epithelial layer that surrounds the animal. Morphogenesis of the epidermis involves cell-cell interactions with internal tissues, such as the developing nervous system and musculature. Genetic analysis of mutants with aberrant epidermal morphology has defined multiple steps in epidermal morphogenesis. In the wild type, epidermal cells are generated on the dorsal side of the embryo among the progeny of four early embryonic blastomeres. Specification of epidermal fate is regulated | [
0.0025970791,
0.0005645108,
0.012751691,
-0.011461381,
-0.031020118,
-0.0075312,
-0.006540426,
-0.0063001383,
-0.0043021324,
-0.025240052,
0.003169819,
0.002420978,
0.0049867867,
0.015496893,
-0.03702401,
-0.0006147079,
0.038524985,
0.0019321742,
-0.012771441,
0.052850064,
-0.004203384,
-0.010368567,
-0.0030068844,
-0.012297449,
-0.017643021,
0.02144812,
-0.008650347,
-0.035575703,
-0.0076628644,
-0.026346033,
-0.004486462,
0.0061750575,
-0.00585248,
-0.0107635595,
-0.0016869493,
0.01528623,
0.029519144,
-0.02015781,
0.01377209,
0.003118799,
0.030967452,
-0.010203986,
-0.011283633,
-0.0009463374,
-0.026938524,
0.0026184744,
-0.021263791,
-0.018959664,
-0.018670004,
0.008229021,
0.011935372,
0.020263141,
-0.016313212,
0.0033492115,
-0.020723967,
0.001269738,
0.009275752,
-0.01749819,
0.016471209,
-0.0059874356,
-0.0018268427,
0.02392341,
-0.007939359,
0.0151150655,
-0.023857579,
0.021184793,
-0.0060664346,
0.01094789,
-0.0023436253,
-0.0020539637,
0.040973943,
0.014614741,
-0.0039795544,
-0.026306534,
0.024937226,
-0.003940055,
-0.02883449,
0.0048518307,
-0.013916921,
0.017853685,
0.0021790448,
-0.038419653,
-0.012304032,
0.03238943,
0.019881316,
-0.0027221602,
-0.003900556,
0.0052929064,
0.0045621693,
-0.015101899,
0.019815482,
0.01297552,
0.03152044,
0.010855725,
-0.018538339,
-0.001999652,
0.006807046,
0.03702401,
0.0010936368,
-0.027228184,
-0.009920908,
0.025595548,
-0.014996568,
-0.021500787,
-0.02566138,
0.008624014,
0.02337042,
-0.011579879,
0.04629318,
-0.016866202,
0.006826796,
0.012567361,
0.011862957,
-0.048373476,
0.025608713,
0.009532498,
0.031625774,
0.012080203,
-0.017063698,
0.0069387103,
0.0017840518,
0.041816592,
0.013995919,
-0.03433806,
0.042922575,
0.018209178,
-0.0058886874,
0.0023304587,
-0.0140090855,
-0.008591098,
0.021737782,
-0.012448863,
0.013080852,
0.013186184,
-0.010618729,
-0.01716903,
-0.02480556,
-0.00013876187,
-0.009578581,
-0.02130329,
0.009130922,
0.010822808,
-0.02551655,
0.034785718,
-0.011454797,
0.017577188,
0.015970884,
0.02281743,
0.026569864,
0.0114811305,
0.027043855,
-0.0062902635,
0.025779877,
-0.023791745,
0.0062836804,
0.036497355,
0.017959015,
0.025055723,
-0.010269818,
0.007011126,
0.0019469864,
-0.0058722296,
0.0013742466,
-0.009894575,
0.018933332,
0.036339357,
0.014680574,
0.008518683,
0.01612888,
-0.001714928,
-0.022501435,
0.014851737,
-0.029835138,
0.02337042,
-0.012857023,
0.0045062117,
-0.01358776,
0.007616782,
-0.02883449,
-0.022712098,
-0.01942049,
0.009282336,
0.017300693,
-0.00087474496,
-0.016405376,
0.010039406,
0.0034101063,
0.008887343,
-0.0016935326,
-0.013423179,
-0.024673896,
0.015944552,
0.024041908,
0.022975426,
-0.62861824,
-0.022843763,
0.015167732,
-0.019196661,
0.01281094,
0.007906443,
-0.0049044965,
-0.014088084,
0.010243486,
-0.0013149976,
-0.008038108,
0.010473898,
0.0149702355,
-0.022883262,
-0.021987945,
-0.022211773,
-0.004779415,
-0.02396291,
0.016734537,
0.0017906349,
-0.038314324,
-0.025977373,
-0.022514602,
0.012284283,
-0.0011446568,
0.024094574,
0.012863605,
-0.008110523,
0.013166434,
0.025042556,
-0.03138878,
0.009789243,
-0.02433157,
-0.0150624,
0.03159944,
-0.0017396151,
-0.0024176864,
0.019881316,
0.0008368914,
0.04803115,
-0.023976076,
-0.0017725312,
0.021566618,
0.0133770965,
-0.02728085,
0.008650347,
0.00806444,
0.0012220097,
0.009519331,
0.015404727,
0.0019831941,
0.00622114,
-0.016853034,
-0.015786555,
0.009723411,
-0.011593045,
0.0067609637,
-0.008604265,
0.013653592,
-0.0037721833,
0.00053776655,
0.006188224,
-0.029255815,
-0.022975426,
0.006839962,
0.02373908,
-0.026122205,
0.015088733,
-0.0014713489,
-0.006698423,
0.0009035465,
0.03865665,
-0.00888076,
0.024608064,
-0.0014754635,
0.021540286,
-0.003597728,
0.0122711165,
-0.0025904959,
0.01938099,
-0.0035582287,
-0.0031500692,
-0.04086861,
0.012027537,
0.014601575,
-0.025463883,
-0.013706258,
0.002834075,
-0.010750393,
0.007860361,
0.0016458043,
0.0038972644,
-0.0069189607,
-0.0510331,
-0.033785067,
0.014311913,
-0.007847195,
0.012547611,
0.001218718,
-0.02566138,
-0.002480227,
-0.0169057,
0.0035516454,
-0.013903754,
0.03599703,
0.0053587384,
-0.03523338,
0.011566712,
0.041737594,
-0.039525636,
-0.007893277,
0.0004013705,
-0.017524524,
0.0066128415,
-0.0036372272,
-0.021908946,
0.0024061657,
0.0034693552,
-0.00024049314,
-0.034838382,
0.017037366,
-0.0058294386,
-0.014562076,
-0.010427816,
0.030546127,
-0.008564766,
-0.008828094,
-0.021500787,
-0.0038182659,
-0.0068662954,
0.0053356974,
-0.003413398,
0.01565489,
-0.029124152,
0.003814974,
0.016563373,
0.0108491415,
0.0030315714,
0.002294251,
-0.015905052,
-0.037498005,
-0.014904403,
0.013508761,
-0.015707556,
-0.019143995,
-0.03489105,
-0.0066292994,
-0.001219541,
0.0065206764,
0.0020539637,
-0.0062935553,
0.0012730296,
-0.01240278,
0.018670004,
0.022527767,
-0.006198099,
-0.013627259,
0.000110371744,
0.01639221,
-0.008972924,
0.009012423,
0.015747055,
-0.030230131,
0.0338904,
-0.018064346,
-0.0076628644,
-0.02148762,
0.0013059457,
-0.003219193,
-0.03489105,
-0.010092071,
0.0107635595,
-0.018551504,
0.0012228325,
-0.005599026,
0.015457394,
0.0045621693,
-0.033047747,
-0.017735187,
-0.010658228,
0.0008640472,
-0.024186738,
0.0045259614,
-0.010065738,
0.02093463,
-0.0018465923,
0.0509541,
0.007103291,
0.0067609637,
0.03038813,
0.009683912,
0.020407973,
-0.016405376,
0.026662027,
0.0004966214,
-0.034759384,
0.042738244,
0.01583922,
0.009460082,
0.0394993,
0.015602224,
-0.016523873,
-0.011862957,
-0.002294251,
0.019947147,
-0.025595548,
0.0026464532,
-0.020802965,
-0.009953824,
0.009756328,
0.00006336346,
0.005467362,
-0.0032949,
-0.020249976,
0.023238756,
-0.00622114,
-0.03094112,
0.0014491306,
-0.020789798,
0.0019782567,
0.0055430685,
-0.010941306,
0.0032208387,
0.010750393,
-0.0066194246,
0.03599703,
0.0113363,
0.012613444,
0.012837273,
-0.01168521,
0.0050888266,
0.012264533,
0.0019140703,
-0.013824755,
0.014588408,
0.01823551,
0.004239592,
-0.018775335,
0.02103996,
0.009828743,
0.008360686,
0.029861473,
-0.0057043573,
-0.0083080195,
0.00054846425,
-0.021566618,
0.022317106,
0.00039190712,
-0.0018400091,
-0.025819376,
0.019657485,
0.0058129807,
0.0011487714,
-0.010164487,
-0.011171719,
-0.012047287,
-0.0045950855,
0.017945848,
0.02470023,
0.03001947,
0.0003781235,
-0.025082055,
-0.008722763,
-0.006504218,
0.011184885,
-0.009571997,
0.0019041955,
-0.0022399395,
-0.0357337,
-0.0070242924,
-0.02175095,
0.013495594,
-0.013890588,
-0.032652754,
0.0026727861,
0.004479879,
0.01911766,
-0.0013964649,
0.008439684,
0.024687063,
-0.012633193,
-0.009769494,
0.016155215,
0.031283446,
-0.0054344456,
0.006899211,
-0.002983843,
-0.000807267,
-0.0054015294,
0.01418025,
0.0049867867,
0.01428558,
0.0051842835,
-0.020368474,
-0.024963558,
-0.0044535464,
-0.007959109,
-0.014838571,
0.036313023,
-0.007913027,
0.017261194,
0.0037359756,
-0.0096575795,
0.003429856,
0.03562837,
-0.000042328025,
-0.012751691,
-0.031257115,
-0.016523873,
-0.039815295,
-0.017063698,
-0.009196754,
-0.0013158205,
-0.016405376,
-0.01982865,
-0.013370513,
0.013758923,
0.009473249,
0.020829298,
0.0067148814,
-0.015036067,
-0.029703474,
-0.01469374,
-0.015154565,
0.02484506,
0.034759384,
0.010473898,
0.03149411,
0.02204061,
-0.023014925,
-0.004246175,
-0.013001854,
0.01152063,
-0.013047935,
-0.008525265,
0.01974965,
-0.00714279,
-0.0132915145,
0.012350115,
0.0059281867,
-0.023251923,
-0.009512749,
-0.011013722,
0.0017182196,
0.008663514,
-0.023291422,
0.022475103,
0.035128046,
0.002269564,
0.009473249,
0.0032981916,
0.015233564,
-0.011198052,
-0.009683912,
-0.001723157,
-0.0014688802,
0.0054838196,
0.029282149,
0.0071559567,
-0.016892534,
0.007913027,
0.012922855,
0.0019058413,
-0.0021378996,
-0.00016571191,
0.014522577,
0.00079245475,
-0.008670096,
-0.003076008,
-0.010467315,
0.011053221,
0.0025855585,
-0.012435697,
-0.012020954,
0.003201089,
-0.010500231,
-0.0041902177,
-0.016181547,
0.0037952245,
0.02226444,
0.0028126794,
-0.004621418,
-0.0010310963,
-0.0034989798,
0.0042659245,
-0.007590449,
0.0075641163,
-0.0066260076,
-0.020486971,
0.0011874477,
-0.0067675468,
0.0057405652,
-0.03518071,
-0.02595104,
-0.0011043346,
-0.03157311,
-0.04068428,
-0.011151969,
0.0062408894,
0.031731106,
0.0010524918,
-0.017221695,
0.019078162,
0.008650347,
0.020052478,
0.0012253012,
0.0054344456,
-0.012099952,
0.005161242,
-0.0020407971,
0.0015914927,
-0.018999163,
-0.02764951,
0.004019054,
0.0042560496,
0.0031220906,
-0.008814927,
0.0053817797,
-0.015812887,
0.0067741303,
0.0131466845,
0.025463883,
-0.01279119,
-0.022883262,
-0.0049407044,
-0.03905164,
-0.025266387,
-0.01653704,
0.004967037,
-0.010460732,
0.002564163,
0.0008624014,
-0.01974965,
0.011309966,
-0.0033837734,
-0.017221695,
-0.0068465457,
0.01186954,
0.010026239,
0.0108491415,
-0.00071839354,
0.0149570685,
0.010296151,
0.014483077,
0.00041309686,
-0.014759572,
0.03407473,
0.013311264,
-0.041632265,
0.014127583,
-0.0037096427,
0.01446991,
-0.04389689,
-0.016484374,
-0.014035419,
0.013521927,
0.0140090855,
-0.040710613,
0.001478755,
0.009104589,
0.007011126,
0.0020276308,
0.0034002315,
0.00086816173,
0.0009948886,
0.013614092,
0.003135257,
-0.021369122,
0.016405376,
-0.0435019,
0.010164487,
0.035496704,
0.0044502546,
0.0072744545,
0.01731386,
0.012646359,
0.01772202,
-0.005457487,
0.0027122854,
-0.048979133,
-0.0044996287,
-0.009124339,
0.036155026,
0.03341641,
0.028729158,
0.016550208,
0.046714507,
0.04818915,
0.0016268775,
0.011599628,
-0.017840518,
0.033126745,
-0.023107091,
0.020789798,
0.006800463,
0.008814927,
0.028808156,
-0.01735336,
0.025332218,
0.036313023,
-0.00087227626,
-0.0046016686,
0.007873528,
-0.020381639,
-0.03636569,
0.016379043,
-0.015575891,
-0.0038050993,
-0.03499638,
-0.01338368,
-0.008946592,
0.009104589,
-0.016194714,
-0.030230131,
0.007676031,
-0.013732591,
0.01813018,
-0.006247473,
0.0123435315,
0.00045959084,
-0.01620788,
0.0050427443,
-0.022185441,
0.0017626563,
-0.0075970325,
0.024489567,
0.009736578,
0.011764209,
0.011428464,
0.021184793,
0.009209921,
-0.027122853,
-0.012106536,
-0.012560777,
-0.022725265,
-0.011658877,
-0.014838571,
-0.027623178,
-0.003640519,
0.008821511,
-0.02355475,
0.040763278,
-0.0029163652,
-0.011843207,
-0.011770791,
-0.010487065,
0.026741026,
-0.037313674,
0.011751042,
0.021421788,
-0.0017577189,
-0.0110071385,
-0.012369865,
-0.006158599,
0.007840611,
0.037577003,
-0.002756722,
0.022435604,
-0.045898188,
-0.0048715803,
0.007728697,
-0.017142696,
-0.028439498,
0.017155863,
0.0018153221,
0.0008846198,
-0.011125636,
-0.004730041,
-0.021987945,
0.013627259,
-0.024252571,
0.01716903,
-0.031072784,
-0.011744459,
-0.018406674,
0.010967639,
-0.012988687,
0.016273713,
0.011033472,
0.020723967,
-0.004878164,
-0.0063001383,
-0.018762168,
0.017248029,
0.0060466845,
-0.0025213722,
-0.0169057,
0.0060335184,
0.02111896,
0.005763606,
0.011652294,
-0.0004108339,
-0.019091329,
0.042948905,
-0.014193416,
-0.011402132,
0.00924942,
0.004177051,
0.013693091,
-0.02772851,
0.0022926053,
-0.020987295,
-0.009130922,
-0.011678627,
0.022514602,
0.0047991653,
0.013548261,
-0.0032718587,
-0.02525322,
0.0033936482,
-0.023396753,
-0.016444875,
-0.01358776,
-0.027860174,
0.0016425126,
0.005891979,
0.017629854,
0.012178951,
0.005480528,
0.0066523408,
-0.015352062,
0.028702825,
-0.013021603,
0.023383586,
0.0021247333,
0.006807046,
-0.02754418,
0.0009191817,
-0.0016680226,
-0.0470305,
0.003571395,
-0.019104496,
-0.034206394,
-0.00433834,
0.017063698,
0.0143250795,
-0.016365876,
-0.026280202,
-0.0155890575,
0.009407417,
0.03499638,
-0.0015075566,
-0.007537783,
0.020816132,
-0.008229021,
-0.016273713,
0.021421788,
-0.0031829854,
-0.0096575795,
-0.005052619,
-0.017735187,
-0.013350763,
-0.034048397,
0.004677376,
-0.016352711,
0.0056286505,
0.013785256,
-0.0019157161,
0.00034623605,
-0.009604913,
-0.03423273,
0.02097413,
0.0049571623,
-0.027886506,
-0.033205748,
0.0034068148,
0.012712192,
0.034259062,
-0.011988038,
0.0034923966,
-0.007992025,
-0.03776133,
-0.04078961,
-0.0022053777,
-0.019920815,
0.042843577,
0.0263987,
-0.0051316177,
-0.020263141,
0.0069979597,
-0.030546127,
-0.032626424,
0.035786368,
0.008624014,
0.02687269,
0.009868242,
0.0054772366,
0.00027464356,
0.0041605933,
0.017853685,
0.005253407,
-0.0018038014,
0.022145942,
-0.016997866,
0.01602355,
0.00082783954,
-0.012363281,
-0.016879369,
0.027991839,
-0.002101692,
-0.015918218,
0.013719424,
-0.017932683,
0.023594249,
-0.01676087,
0.019209826,
0.01410125,
0.01786685,
0.02695169,
-0.023449419,
0.012527862,
0.00077476236,
-0.01683987,
-0.027412515,
-0.00077558524,
-0.009051923,
0.013258599,
0.024041908,
-0.022791097,
-0.0119551215,
-0.0026036622,
-0.020407973,
0.028544828,
0.027465181,
-0.0036503938,
0.0063923034,
0.01131655,
-0.0055397768,
-0.028887156,
-0.0061750575,
-0.03618136,
-0.0015733888,
-0.01358776,
-0.021461288,
0.0028850948,
-0.011876123,
0.0006110048,
-0.052428737,
0.006053268,
-0.00012466966,
0.0019716735,
-0.0117971245,
0.036576353,
-0.0053751967,
0.0031961517,
-0.0061421413,
0.00025407103,
0.0039203055,
-0.016695037,
0.00059578114,
-0.020394806,
0.013930087,
0.00593477,
-0.022435604,
-0.005078952,
0.014535743,
-0.0026003707,
-0.0017280944,
-0.022172274,
0.022975426,
0.16853034,
-0.0038018078,
-0.0044667125,
0.0070637916,
0.0035121462,
-0.019631153,
-0.0018136762,
0.016300045,
0.0024604774,
0.006800463,
-0.008406768,
0.0027715343,
-0.012508112,
0.007985442,
0.053429388,
-0.03836699,
-0.023910243,
0.017537689,
-0.009209921,
-0.014035419,
0.0338904,
-0.021382289,
0.011645711,
0.017511357,
0.041711263,
-0.0071559567,
-0.037708666,
0.009828743,
-0.0025032682,
0.0042494666,
-0.015233564,
0.012784607,
0.022646265,
0.0022629807,
-0.005276448,
-0.0069189607,
-0.020829298,
0.0058294386,
-0.012494946,
0.002799513,
0.009137505,
-0.0018005098,
-0.0010022947,
-0.0015478788,
-0.0057932306,
0.01528623,
0.0077484464,
0.0003345097,
-0.008637181,
-0.00734687,
-0.024213072,
0.013548261,
0.027570512,
0.02103996,
-0.0038445985,
-0.02159295,
0.010513397,
0.010434398,
0.012060453,
0.043396566,
-0.025332218,
0.012317198,
-0.0226726,
0.022159107,
-0.005513444,
0.03499638,
0.004354798,
0.013719424,
0.024357902,
-0.04113194,
-0.010236902,
-0.024608064,
-0.02144812,
0.020789798,
0.00248681,
-0.016589707,
0.012336948,
0.012771441,
0.0005945468,
0.022843763,
0.02429207,
-0.010302735,
-0.016668705,
0.006000602,
-0.018024847,
-0.045424197,
0.035970695,
0.039156973,
-0.0026958273,
-0.028860822,
0.0019321742,
-0.02015781,
0.003429856,
0.010506814,
0.03849865,
-0.016734537,
-0.006514093,
0.011698376,
-0.016471209,
0.010013073,
-0.024239404,
0.038735647,
0.019143995,
-0.013370513,
0.0037425589,
0.018999163,
-0.0008582869,
0.010236902,
-0.0022465228,
-0.0143250795,
0.011606211,
-0.0010113467,
0.0130611025,
0.0019535697,
-0.005404821,
0.012837273,
-0.0007192164,
-0.023976076,
0.018314509,
-0.014246081,
-0.02222494,
-0.020039313,
0.008933425,
0.021948446,
-0.009058506,
0.0016400439,
-0.022949094,
0.016734537,
0.0019404031,
-0.04121094,
0.010269818,
-0.0014417245,
0.005167825,
0.029887805,
-0.0028620535,
-0.024937226,
0.0045522945,
-0.01170496,
-0.027043855,
0.02772851,
-0.024766061,
0.0020243393,
0.008426517,
0.0014614741,
0.009492999,
-0.016418543,
0.018380342,
0.041553266,
-0.02809717,
-0.018577838,
-0.021685116,
-0.021579785,
0.0123435315,
-0.023028092,
0.0014697032,
-0.038946312,
-0.01956532,
-0.015009735,
0.012494946,
-0.0022481685,
-0.012909688,
0.011731292,
-0.024792396,
-0.02764951,
0.01184979,
-0.011000555,
-0.1636851,
-0.0057043573,
0.017787851,
-0.022303939,
0.02369958,
0.022172274,
-0.020381639,
0.008564766,
-0.022093276,
0.006859712,
0.035575703,
0.023673248,
-0.05851163,
-0.043212235,
0.013969586,
0.017537689,
0.00046411678,
0.029229483,
0.014272414,
0.013008436,
0.03884098,
-0.025411217,
0.023949742,
0.011862957,
0.01745869,
0.049295127,
0.0049407044,
0.0033228786,
0.008946592,
-0.03086212,
-0.018999163,
0.016458042,
0.018038014,
0.0112968,
0.0110795535,
-0.008617431,
-0.007432452,
-0.008847844,
0.0022547517,
0.017063698,
0.01653704,
-0.007537783,
-0.008163189,
-0.007471951,
-0.008663514,
0.033995733,
0.008176356,
0.02506889,
0.026148537,
-0.027096521,
0.024910893,
0.021053128,
-0.0071625398,
0.0073929527,
0.03755067,
0.004479879,
0.02373908,
0.019262493,
0.013508761,
-0.024621231,
0.020763466,
-0.016115716,
0.028755492,
0.00904534,
0.008097357,
-0.018630505,
-0.007386369,
0.02754418,
-0.028966155,
-0.012764857,
-0.00976291,
0.0008846198,
0.0026102455,
-0.03865665,
0.035049047,
0.011448214,
-0.005549652,
-0.006596383,
-0.014680574,
-0.0020062353,
-0.0226331,
0.014785905,
-0.011013722,
-0.031362444,
-0.010980805,
0.0062310146,
-0.0062902635,
0.010967639,
-0.002462123,
0.002806096,
0.0005797345,
-0.017471857,
0.010651645,
-0.018038014,
0.03518071,
0.03252109,
-0.016010383,
-0.016510708,
-0.009236253,
0.006053268,
0.042580247,
0.0073600365,
-0.0030957577,
0.024252571,
0.013653592,
-0.017327027,
-0.013521927,
0.019262493,
0.075838655,
0.0055957343,
-0.010546314,
-0.0012162493,
0.02097413,
0.0076101986,
0.0005817918,
0.016365876,
0.00051842834,
-0.0077484464,
0.0055792765,
-0.008637181,
0.05803764,
-0.005016411,
-0.0010936368,
0.020355307,
-0.014772738,
-0.02938748,
-0.13229632,
-0.024213072,
-0.0025345385,
0.023265088,
0.01676087,
0.0074785342,
-0.016997866,
0.022883262,
-0.005608901,
0.014588408,
-0.028676493,
-0.013877421,
-0.0017955723,
-0.020855632,
0.004496337,
-0.0071559567,
0.0059709777,
0.015457394,
-0.01776152,
0.025016224,
-0.0065108016,
-0.01993398,
-0.023936577,
-0.0064186365,
0.010730644,
0.020592302,
-0.03525971,
0.00620139,
0.02562188,
0.0005723284,
0.0016737828,
-0.021553451,
0.014680574,
-0.010546314,
-0.008334353,
-0.014496244,
-0.0035450624,
-0.0046707923,
0.013107184,
-0.015088733,
-0.002689244,
0.0018828,
0.023212422,
-0.012455447,
-0.010618729,
0.006853129,
-0.024450067,
-0.0017182196,
0.0044337967,
-0.017985348,
-0.037577003,
-0.019986646,
0.00806444,
-0.022066943,
0.015009735,
-0.030414462,
0.00051390234,
0.0083936015,
0.0020144645,
0.01952582,
-0.003943347,
0.0009874825,
-0.015812887,
-0.023265088,
0.015681222,
-0.0127451075,
-0.052771065,
-0.038340654,
0.021145292,
-0.03267909,
0.0040815943,
0.024160406,
0.007498284,
-0.00075583556,
-0.027017523,
-0.00849235,
-0.0012787898,
0.007281038,
-0.005582568,
-0.01319935,
-0.0029690308,
-0.016681872,
0.02572721,
0.011882707,
0.026267035,
0.023844412,
0.030177467,
-0.011533796,
0.0044601294,
-0.00480904,
-0.0037754748,
0.03231043,
0.02551655,
-0.028808156,
-0.0011553545,
-0.006286972,
0.0124291135,
0.0009792536,
0.029282149,
0.030625125,
-0.003959805,
-0.010625312,
-0.040973943,
0.01410125,
-0.027754841,
-0.0035582287,
0.021395454,
-0.00499337,
-0.0033130038,
0.00963783,
-0.0020111727,
0.034654055,
-0.005763606,
-0.009486415,
-0.010230319,
-0.01938099,
-0.04078961,
-0.030335464,
0.04160593,
-0.0050987015,
0.029229483,
0.029914137,
0.004878164,
-0.006504218,
0.0149702355,
0.00525999,
-0.013186184,
-0.013008436,
-0.010533147,
-0.01905183,
0.0075706993,
-0.01543106,
0.021092627,
-0.033916734,
0.0060401014,
0.022198608,
-0.0022728557,
0.009302085,
0.019354658,
0.015826054,
0.03159944,
0.031889103,
-0.018182846,
-0.027254518,
0.023502083,
-0.0032060265,
-0.010572646,
-0.0006073018,
-0.026938524,
-0.002975614,
-0.0033903567,
-0.0014812237,
0.043106902,
0.0014943902,
0.0026085996,
-0.020579135,
-0.0021658784,
-0.030756788,
-0.01131655,
-0.0029361148,
-0.018775335,
-0.029150484,
0.030756788,
0.0057866476,
0.017485024,
-0.024529066,
-0.0088675935,
-0.005236949,
-0.018854333,
-0.008782011,
-0.011546962,
-0.04405489,
-0.028544828,
-0.00297726,
0.0009323481,
0.0071691233,
-0.006421928,
0.007287621,
-0.02392341,
0.0025822667,
-0.007386369,
0.029413814,
0.023686415,
0.01745869,
-0.017445525,
0.020144643,
0.036418356,
0.005520027,
0.004667501,
-0.00527974,
-0.008360686,
-0.00014976818,
-0.02281743,
0.013653592,
0.011329716,
0.010572646,
0.0025361844,
-0.0021987944,
0.009795827,
0.017261194,
-0.0013627259,
0.021224292,
0.00037195176,
0.035602037,
0.02650403,
-0.02754418,
-0.0030496751,
0.01683987,
-0.013080852,
-0.034864716,
-0.008301437,
-0.0188675,
-0.0035746868,
-0.00021992059,
0.008314603,
-0.007985442,
-0.023304587,
0.01790635,
0.006741214,
-0.006547009,
-0.010118404,
0.025187388,
0.012843856,
0.024094574,
-0.020513304,
-0.008446267,
0.011013722,
0.0032422342,
0.019170327,
-0.02340992,
0.017037366,
-0.0031155073,
0.004766249,
-0.003118799,
0.0017889892,
-0.0034166896,
0.0003392414,
-0.019854981,
0.0054410286,
0.008202688,
-0.027939172,
0.088741764,
0.009479832,
-0.018999163,
0.033363745,
-0.021316456,
0.028702825,
0.0012244784,
0.020078812,
-0.020908296,
-0.016484374,
0.026596196,
-0.029808806,
0.017287528,
-0.013357347,
-0.023054425,
0.034206394,
-0.019736484,
0.017774686,
0.0027270976,
-0.020039313,
0.015022901,
-0.0013322785,
0.007985442,
0.0075772824,
-0.013745757,
0.005520027,
0.013028186,
0.024634397,
0.008498933,
0.001379184,
0.008617431,
-0.021579785,
-0.031020118,
-0.003362378,
-0.01956532,
0.011744459,
-0.010230319,
-0.009506165,
-0.0028521786,
0.020289475,
-0.018762168,
-0.0143250795,
-0.0131466845,
-0.018959664,
-0.021619285,
-0.007689197,
-0.0075575328,
-0.00025797982,
-0.027939172
] |
Using high-throughput sequencing, we devised a technique to determine the insertion sites of virtually all members of the human-specific L1 retrotransposon family in any human genome. Using diagnostic nucleotides, we were able to locate the approximately 800 L1Hs copies corresponding specifically to the pre-Ta, Ta-0, and Ta-1 L1Hs subfamilies, with over 90% of sequenced reads corresponding to human-specific elements. We find that any two individual genomes differ at an average of 285 sites with respect to L1 insertion presence or absence. In total, we assayed 25 individuals, | [
-0.023174318,
0.0011640107,
-0.01275544,
-0.02147997,
-0.009394071,
0.0012374553,
-0.020318521,
-0.012407006,
-0.039762538,
0.022381801,
0.010801474,
0.005571538,
-0.0062889033,
0.006896956,
0.012441166,
0.013069714,
0.012331853,
-0.025879811,
0.009687849,
-0.011293381,
-0.022381801,
-0.013800744,
-0.014142347,
-0.018993102,
-0.013083379,
-0.0024851586,
0.0229147,
-0.0074674324,
-0.018747149,
-0.019225392,
0.016096313,
0.011272885,
-0.040609714,
-0.021876229,
-0.026180422,
-0.028749272,
-0.0014219207,
0.010944947,
0.024158133,
-0.0362372,
0.018473867,
0.031181483,
0.0048336764,
-0.0061317664,
0.008690369,
-0.018309899,
0.0008642545,
-0.0072419746,
-0.03230194,
0.002256285,
-0.009722009,
0.010371054,
-0.016164634,
0.009448727,
-0.01835089,
-0.00030445328,
0.0076109054,
0.008041324,
0.0021777165,
-0.031263467,
-0.025934467,
-0.0061454303,
-0.026918283,
0.014074026,
-0.015167154,
0.010828801,
0.013199523,
-0.0019556747,
0.009216437,
0.0016542105,
0.02954179,
0.008177966,
-0.0066202576,
-0.01055552,
0.024458744,
-0.021261344,
-0.012878417,
0.0024373343,
0.009995291,
0.017940966,
0.01858318,
-0.004642379,
-0.002515903,
0.01841921,
0.003723468,
0.015358452,
0.009277926,
0.021657603,
-0.0056466907,
-0.0038737732,
0.011751128,
0.007870523,
0.012044907,
0.02254577,
-0.015413108,
0.006097606,
-0.016492572,
0.011764793,
-0.010610176,
-0.04170284,
-0.01871982,
-0.011819449,
-0.005048886,
-0.0080208285,
-0.0010393258,
-0.0003742683,
0.0075152568,
-0.024581721,
-0.007037013,
-0.0040719025,
-0.02954179,
0.03254789,
-0.010637504,
-0.002136724,
0.013793912,
-0.02331096,
0.029405149,
-0.00238097,
0.007911515,
-0.015003185,
0.043397192,
0.017203106,
-0.0034348138,
-0.025128284,
0.020810429,
0.025251262,
-0.021220353,
-0.01275544,
-0.012099563,
-0.0056432746,
0.0019403026,
-0.0049395734,
0.02018188,
0.025360575,
-0.018268906,
0.0045057377,
0.006367472,
0.0029104538,
-0.020605467,
-0.026959274,
0.021001726,
0.017421732,
-0.0071531576,
-0.008266782,
0.026098436,
0.028858585,
0.022450121,
-0.00055296917,
0.0058414037,
0.000009394071,
0.012577807,
0.020742107,
-0.004256368,
-0.002650836,
0.008335102,
0.0053665764,
0.012338685,
0.01688883,
-0.026030116,
-0.023228975,
-0.008109645,
0.0048815007,
0.018706156,
0.023857523,
0.015877688,
0.019102415,
0.026713321,
-0.015221811,
0.012912577,
-0.022627754,
-0.0055134655,
0.005007894,
-0.024827674,
0.0081984615,
-0.023133326,
-0.012051739,
-0.016041657,
0.0022306647,
-0.010787809,
-0.024363095,
0.019553332,
0.034980103,
0.04019979,
0.010992771,
-0.033149112,
-0.0034723901,
-0.001458643,
-0.01478456,
0.008355599,
-0.025005309,
0.005711595,
0.0064528724,
0.0043281047,
-0.0069686924,
-0.6401359,
-0.003863525,
-0.006784227,
-0.010453039,
-0.0039250134,
0.01302189,
0.013431813,
0.013684599,
-0.02141165,
0.011532503,
-0.013964714,
0.00632648,
0.027492175,
-0.006408464,
-0.04293261,
-0.03872407,
0.006234247,
-0.001984711,
0.036155216,
-0.0036209873,
-0.023065006,
-0.005185527,
0.004147055,
0.014169674,
0.015358452,
0.005694515,
0.0048370925,
-0.014839216,
-0.014880208,
0.023092333,
-0.012728112,
0.014757231,
-0.012748608,
0.0057764994,
0.040882997,
-0.020386841,
-0.010671664,
0.0364285,
0.011723801,
0.025141949,
-0.014948528,
-0.012208876,
0.028011411,
0.029432477,
-0.0056296103,
0.012331853,
0.0017882894,
-0.005834572,
-0.0043178564,
-0.02124768,
0.014606926,
-0.009564872,
-0.015590741,
-0.0128579205,
0.00030189127,
0.003720052,
0.018665165,
-0.013117539,
0.04082834,
-0.0073444555,
0.0007733028,
0.0011050843,
0.015413108,
-0.006384552,
-0.019457683,
0.0027379447,
0.0029446143,
0.0044613294,
0.008444415,
-0.019881269,
0.016027993,
0.028202709,
0.002773813,
0.008608385,
0.010965442,
0.04033643,
0.009817658,
-0.004683371,
-0.0064426246,
0.0147435665,
-0.0026440038,
0.0024902828,
-0.02161661,
-0.003439938,
0.013971545,
0.009551208,
-0.029651104,
0.03093553,
-0.0014842632,
0.024814012,
0.010883458,
0.000092552946,
-0.013192691,
-0.036373843,
-0.021630274,
0.0037029719,
-0.0056296103,
0.0043144403,
0.0048780846,
-0.024007829,
-0.011252388,
-0.0036073232,
0.025592865,
0.003590243,
0.04173017,
-0.0043178564,
-0.011607655,
0.008123309,
0.018993102,
-0.02541523,
-0.024103478,
-0.013636774,
-0.008253118,
0.0077953706,
-0.011710136,
-0.027587824,
-0.004758524,
0.026795305,
-0.014948528,
-0.028120724,
0.023720883,
0.01552242,
-0.004270032,
-0.0154541,
0.016123641,
0.0218489,
0.008772354,
-0.0009684433,
0.032165296,
-0.01425166,
-0.0033425812,
-0.021234015,
0.015167154,
-0.02956912,
-0.007323959,
-0.0012306232,
0.023502257,
0.00636064,
0.0014159427,
-0.016670205,
-0.021698596,
-0.019362034,
-0.0006302567,
-0.013329333,
-0.007023349,
-0.03306713,
-0.0004389593,
-0.009004644,
0.017667685,
0.01445662,
0.011983418,
0.008765522,
-0.010159261,
0.015331123,
0.0034775143,
-0.0080208285,
-0.03716636,
-0.04462696,
-0.0016294443,
-0.020591803,
0.0021657604,
0.026426375,
0.023474928,
-0.015167154,
0.009079796,
-0.028749272,
0.027560495,
0.03293049,
-0.014429293,
-0.04033643,
0.022682412,
-0.024089813,
-0.009216437,
0.012366013,
0.0036893077,
0.026959274,
0.006941364,
0.020031575,
-0.009038804,
-0.024991645,
-0.01978562,
0.0066646663,
-0.006521193,
-0.008656209,
0.0052196872,
0.008499072,
0.0073717833,
-0.015139826,
0.029104538,
0.026645001,
-0.00021360836,
-0.014224331,
-0.006937948,
0.017312419,
0.0109039545,
0.010316398,
0.02687729,
0.009667353,
-0.005950717,
0.010719488,
0.016601885,
-0.002379262,
-0.0075084246,
-0.04719581,
0.00842392,
-0.032383922,
-0.011512007,
-0.032957815,
0.011744296,
-0.012844257,
-0.001461205,
-0.0000598872,
-0.0091959415,
-0.01195609,
-0.008908995,
0.024950651,
-0.019430354,
0.012372845,
0.011949258,
-0.017558372,
0.0034365219,
0.018145928,
0.024486072,
-0.017435396,
0.010200253,
0.020673787,
0.00005897982,
0.018446539,
0.005014726,
0.020277528,
0.006934532,
0.010487199,
-0.0008207002,
0.027054925,
0.021070046,
0.0053085038,
0.023761874,
-0.0076245693,
0.00739228,
0.022368137,
-0.009107125,
0.008710866,
0.0004099231,
-0.025524544,
0.00501131,
0.016164634,
0.01371876,
0.0034638501,
-0.0016764146,
0.021958213,
-0.00772705,
0.0005734653,
-0.019607987,
0.0144976135,
0.0029668184,
-0.012728112,
0.0147435665,
0.020291192,
0.0362372,
0.022163175,
-0.00023015474,
0.0006392238,
-0.0014432708,
-0.0022733652,
0.005175279,
-0.019607987,
0.0028865417,
-0.009510215,
0.01142319,
0.0019625067,
-0.0058209077,
0.0035185064,
0.009674185,
-0.041210935,
0.0050830464,
0.018596845,
0.0030334308,
0.0064528724,
0.023925845,
-0.009926971,
-0.026754314,
-0.043943755,
0.019922262,
0.020632796,
-0.0144976135,
-0.013370325,
-0.017845318,
-0.016424252,
0.0042153755,
-0.011846777,
0.010193421,
0.0081984615,
-0.0057799155,
0.02430844,
-0.010336894,
-0.0054041524,
0.048015658,
-0.014128682,
0.006753483,
0.0012596595,
0.00929159,
-0.0024185462,
-0.028394006,
-0.017531045,
0.037986204,
0.023324624,
-0.0060327016,
0.002399758,
0.01904776,
-0.008314607,
0.0081301415,
-0.013302004,
-0.008738194,
0.0057423394,
-0.01058968,
0.018241577,
-0.015208147,
0.015003185,
0.017435396,
-0.00091037084,
-0.018610507,
-0.039762538,
-0.009510215,
0.0039045173,
0.019088753,
0.03746697,
-0.015358452,
0.0086972015,
-0.010548688,
0.0076314015,
-0.026699657,
-0.023693554,
0.024486072,
-0.026002787,
-0.016328603,
0.003860109,
-0.004925909,
-0.016929824,
-0.0037610442,
0.025018971,
0.013582118,
-0.02997904,
0.0023741378,
0.012085899,
-0.018159593,
0.016164634,
0.017776998,
0.037986204,
0.015413108,
-0.018542187,
0.033258427,
0.012837425,
0.018637836,
-0.014647918,
-0.006001957,
-0.0032725527,
-0.01005678,
0.023338288,
-0.0016695826,
-0.004109479,
0.016178297,
0.007979836,
0.023597905,
-0.008861171,
0.0026149678,
0.029787743,
0.023297295,
0.01462059,
0.010733153,
0.005971213,
-0.007166822,
0.022860045,
-0.009763001,
-0.023351952,
0.016629213,
-0.016779518,
-0.016793182,
-0.021288672,
0.0040377425,
0.0063093994,
-0.01431998,
-0.012085899,
-0.02178058,
-0.03443354,
0.012208876,
-0.038915366,
0.006001957,
-0.013725591,
-0.013261012,
-0.026426375,
-0.013930553,
-0.0040787347,
-0.034132928,
-0.002133308,
-0.002251161,
-0.02850332,
-0.036127888,
0.0007720218,
0.017490052,
0.010254909,
0.015044177,
-0.004379345,
0.0063333116,
0.020906078,
-0.01928005,
-0.012044907,
0.025934467,
-0.020195544,
0.0019642147,
0.013684599,
0.0060395333,
-0.0052299355,
-0.015440436,
-0.007952508,
0.008854339,
-0.020140888,
0.019252721,
0.018077608,
-0.011464182,
0.0229147,
0.0068115555,
0.02178058,
-0.014593262,
-0.016424252,
0.002259701,
-0.041812155,
0.003583411,
-0.019143408,
-0.0028984977,
-0.012666623,
-0.007166822,
-0.0025551873,
-0.02434943,
-0.045310166,
-0.0032845088,
-0.01675219,
0.014634254,
0.01445662,
0.042140093,
0.025961796,
0.009974795,
-0.0024834506,
0.006469953,
-0.005602282,
-0.00317178,
0.0011042303,
0.026057445,
-0.001591868,
-0.01498952,
0.016342267,
-0.0011665728,
-0.0058004116,
-0.00060164754,
-0.01485288,
0.0048439247,
0.042659327,
0.01145735,
-0.008054988,
0.0020086232,
-0.0135001335,
-0.020687452,
0.000026420825,
0.0026969523,
-0.0020479073,
-0.017462723,
0.007030181,
-0.010118268,
-0.0040684864,
-0.012707615,
-0.021234015,
-0.013472806,
0.03672911,
0.0009394071,
-0.00038857292,
-0.006121518,
0.0027550247,
-0.017722342,
-0.01654723,
-0.011245556,
0.008970483,
0.0073376233,
0.00030936382,
0.039953835,
0.005991709,
0.025483552,
-0.025551872,
0.0027037843,
0.013971545,
0.023351952,
0.0068627954,
-0.0023246056,
-0.00158589,
-0.008116477,
-0.016424252,
0.020332186,
0.0068525476,
-0.0024475823,
-0.010343726,
0.016437916,
0.024226455,
-0.04019979,
-0.00556129,
0.019771956,
-0.039817195,
-0.020277528,
-0.0074059437,
0.00529484,
0.0008740756,
-0.04722314,
-0.0014005705,
0.041210935,
-0.0067227385,
0.02404882,
0.008116477,
0.029104538,
0.013869064,
0.019963255,
0.0007340185,
0.02597546,
-0.0052333516,
0.00018841517,
-0.029787743,
0.015194482,
0.020304857,
-0.022327144,
-0.004143639,
0.0065826816,
-0.006203503,
0.016998144,
0.008929491,
-0.025825154,
-0.009756169,
-0.025579201,
0.002662792,
-0.0048985807,
-0.010726321,
0.004150471,
-0.025702177,
0.001064092,
0.0013698263,
0.010658001,
0.011006434,
-0.0048780846,
-0.018132264,
0.01802295,
0.018965775,
0.038423456,
-0.015358452,
0.023297295,
0.009660521,
0.0054041524,
-0.04017246,
-0.008089148,
0.0042973603,
0.0022938612,
0.03150942,
0.0016354223,
-0.021821572,
-0.00609419,
0.024704698,
0.0022204167,
-0.02847599,
-0.040500402,
0.007289799,
-0.014729903,
-0.017790662,
-0.0090593,
0.007446936,
-0.004358849,
0.00292241,
-0.022026533,
0.030197667,
0.0030163508,
0.016506236,
-0.011894601,
0.015303795,
0.008376095,
0.015495093,
-0.011928761,
-0.026180422,
-0.011901434,
-0.022942029,
0.015536085,
-0.0037952045,
0.0060292855,
0.034378882,
-0.0074810963,
-0.008669874,
-0.005967797,
-0.00792518,
-0.0071941502,
-0.018842798,
-0.004649211,
0.041210935,
-0.030853543,
0.007173654,
-0.0068627954,
0.024431417,
-0.007146326,
0.022108518,
-0.008437583,
-0.0020205793,
-0.015590741,
0.0013040678,
0.02847599,
0.00948972,
0.012666623,
-0.008280447,
-0.024144469,
-0.013547958,
-0.039762538,
-0.027779121,
0.03563598,
-0.049737334,
0.0069857724,
0.006760315,
0.027615152,
0.015481428,
0.03733033,
0.007713386,
-0.02071478,
0.025620192,
-0.030962856,
0.012072234,
0.02331096,
-0.0037576284,
-0.018473867,
-0.0034638501,
0.000663136,
-0.013759752,
0.019840278,
-0.02581149,
-0.01904776,
-0.0040958147,
0.005745755,
-0.015864024,
0.009667353,
0.012208876,
0.010808305,
-0.00476194,
0.03183736,
0.0011827989,
-0.026658665,
0.018268906,
-0.029049883,
0.005814076,
0.0076382337,
0.017298754,
0.016465245,
-0.021876229,
-0.023830196,
0.0066817463,
-0.015426772,
-0.0068252194,
-0.009113956,
0.02321531,
0.004789268,
0.0022528688,
-0.027724465,
0.0014808471,
-0.022190504,
0.009175445,
0.010487199,
-0.009421399,
-0.0037952045,
0.018692493,
-0.003942094,
0.013281508,
-0.002661084,
0.00739228,
0.028038738,
-0.013773415,
-0.032165296,
-0.011512007,
-0.032711864,
0.019430354,
0.0030436788,
-0.010541855,
-0.01275544,
-0.011826281,
-0.05375458,
-0.0076314015,
0.0138895605,
0.015413108,
-0.0142106665,
0.02641271,
0.0027635647,
-0.0056740185,
-0.007037013,
0.016068986,
-0.01115674,
-0.026453704,
0.010733153,
0.00158162,
0.017572036,
0.024800347,
-0.038587425,
0.015604406,
-0.0028165132,
0.01245483,
-0.02115203,
0.023256304,
-0.015495093,
0.043397192,
0.0012254992,
0.001190485,
0.006524609,
0.013643607,
0.010207085,
-0.014019369,
-0.00527776,
0.006114686,
0.0021520962,
-0.019211728,
-0.01695715,
-0.012980898,
0.014757231,
0.016369596,
-0.0058174916,
-0.027888434,
0.006381136,
-0.011696472,
-0.0067671468,
-0.0051103747,
-0.008191629,
0.008587888,
-0.00105299,
0.012495822,
-0.0015662478,
-0.010815137,
0.0037576284,
0.0019420106,
0.019703636,
-0.0018173257,
0.0029651104,
0.00082924025,
-0.0059438846,
-0.014606926,
0.006364056,
0.007057509,
-0.02055081,
-0.01515349,
0.025592865,
0.02704126,
-0.024267446,
-0.017790662,
-0.0116486475,
-0.015276467,
-0.014278987,
0.01498952,
0.0027550247,
-0.028585304,
0.029459806,
0.019635316,
-0.01371876,
-0.025756834,
-0.003306713,
0.011744296,
-0.021397986,
-0.0020871917,
0.18473867,
-0.01375292,
0.004092399,
0.027218893,
-0.015344787,
-0.0015218394,
0.019771956,
0.017107457,
-0.025661185,
-0.007446936,
0.023761874,
-0.018856462,
-0.027656144,
-0.0011802369,
0.015290131,
0.00063153775,
-0.026303397,
-0.00948972,
-0.0031478677,
0.027601488,
0.00056449824,
-0.0042632,
-0.013725591,
-0.02018188,
0.017257761,
0.014115018,
-0.01904776,
-0.015508757,
-0.005421233,
0.019553332,
-0.034624837,
-0.00036679575,
0.014347308,
-0.0026354638,
0.0011008143,
0.007720218,
0.013623111,
0.005175279,
0.011928761,
0.0057662516,
-0.019730965,
0.011716968,
-0.011744296,
-0.018760813,
-0.0087313615,
0.015549749,
0.005995125,
-0.0014483948,
-0.034324225,
0.0035458347,
-0.0154541,
0.01781799,
0.007296631,
0.011095252,
-0.030361636,
0.0069652763,
0.029295836,
-0.0011836529,
0.0021725923,
0.050529853,
-0.0004509154,
0.025032636,
-0.023024013,
0.013910057,
-0.0144976135,
0.02604378,
-0.0048200125,
-0.005547626,
0.03577262,
-0.039215975,
0.022258824,
-0.018405547,
-0.009380407,
-0.01582303,
0.0056466907,
-0.016574556,
0.040746354,
0.023160655,
0.013964714,
0.0025961795,
0.021302337,
-0.017544707,
-0.023297295,
-0.013397653,
0.0044510816,
-0.020673787,
0.0317827,
0.015590741,
-0.006531441,
0.0028318854,
-0.0012630755,
-0.007351287,
-0.012605134,
-0.005667187,
0.0051377025,
0.0028250532,
-0.0008087441,
-0.019730965,
-0.007180486,
-0.028885914,
-0.021807909,
0.07635501,
-0.0032247282,
0.0026935362,
0.0026047197,
0.00985865,
-0.007446936,
0.008868002,
0.012003914,
-0.016560894,
0.039024677,
-0.028093396,
0.009216437,
-0.00010952632,
0.016342267,
0.030552935,
0.005933637,
-0.028230036,
0.027355533,
0.009756169,
-0.014265323,
-0.0070985015,
-0.004932741,
0.05211489,
-0.016875166,
-0.017531045,
-0.042276733,
0.009271094,
-0.0024766186,
-0.007310295,
0.0020239952,
-0.0032144801,
-0.0059199724,
0.018159593,
-0.014115018,
-0.028967898,
-0.0154541,
0.00052435993,
-0.03153675,
-0.014716239,
0.00072804047,
0.0038122847,
0.00845808,
0.0012101271,
-0.004020662,
-0.026248742,
0.019566996,
0.0018173257,
0.004355433,
-0.013964714,
-0.022094855,
-0.006264991,
0.010063612,
0.0076109054,
0.01768135,
-0.00006116821,
-0.010336894,
-0.031208811,
0.0022306647,
0.012427501,
-0.039024677,
0.017599365,
0.023447601,
-0.015659062,
-0.029295836,
0.00932575,
-0.17402601,
0.0025534793,
0.020058904,
-0.034952775,
0.009175445,
0.022764396,
0.03156408,
0.003846445,
0.007590409,
0.029651104,
0.033996288,
0.01165548,
-0.031728048,
-0.0239805,
-0.0068525476,
-0.009011475,
-0.02324264,
0.031755377,
0.02956912,
0.0018019535,
0.006920868,
-0.018842798,
0.00715999,
-0.01085613,
0.019266386,
0.010002123,
0.0021503882,
0.006763731,
0.01751738,
-0.02891324,
-0.0053665764,
0.02041417,
0.031618733,
-0.020660123,
0.023584241,
0.009961131,
0.012208876,
0.0039318455,
0.0073854476,
-0.002519319,
0.023420272,
0.041839484,
0.0042802803,
-0.024895996,
0.004167551,
0.009236934,
0.018555852,
-0.03181003,
0.006801307,
-0.015044177,
0.0031376197,
-0.018200586,
0.03530804,
0.011710136,
0.024130806,
-0.007569913,
0.010186588,
0.018309899,
0.003723468,
-0.0039250134,
-0.007932012,
-0.025141949,
0.016369596,
-0.016205626,
0.010453039,
-0.04372513,
-0.030252324,
-0.02680897,
-0.02817538,
0.016273946,
-0.013937385,
-0.0063982164,
0.010295901,
-0.0068422994,
0.026890954,
0.019293712,
-0.017872646,
0.014019369,
0.019321041,
-0.004768772,
-0.017845318,
0.021452641,
-0.011409526,
-0.012734944,
-0.01698448,
-0.0058038277,
0.0020513234,
0.003590243,
-0.005014726,
0.011696472,
0.006019037,
-0.026194084,
0.015276467,
-0.03309446,
0.013008226,
0.02214951,
0.0039557577,
0.0000071056,
0.00082924025,
-0.008348767,
-0.004106063,
-0.032985143,
-0.006982357,
0.010794641,
0.029077211,
-0.018965775,
-0.024527065,
0.018870126,
0.03989918,
-0.002403174,
-0.010521359,
-0.021807909,
0.011730633,
0.028038738,
-0.00696186,
0.04085567,
-0.019430354,
-0.016998144,
0.017640356,
-0.011710136,
0.055913508,
-0.014647918,
-0.037384987,
0.017435396,
0.00557837,
-0.03150942,
-0.12811463,
-0.00031363385,
0.0012989438,
0.01272128,
-0.008567393,
0.030033698,
0.008745026,
0.025456224,
-0.030334309,
0.019662645,
-0.02644004,
-0.038505442,
-0.016806846,
-0.004741444,
-0.0044237534,
0.009216437,
-0.001453519,
-0.0147435665,
-0.014074026,
0.024472408,
0.012707615,
-0.010015788,
0.012003914,
-0.023174318,
-0.0032930488,
-0.023939509,
-0.02710958,
0.007904683,
0.009066132,
0.016096313,
0.004676539,
-0.005455393,
-0.0020598634,
0.0013570163,
0.0025756834,
0.015481428,
-0.019375699,
-0.00083222927,
0.026180422,
-0.004676539,
-0.009168613,
0.007829531,
-0.029377822,
0.00952388,
0.01941669,
-0.03153675,
0.0063128155,
-0.010897122,
-0.01322002,
-0.036209874,
-0.02404882,
-0.014224331,
-0.034324225,
-0.017763333,
0.0017156989,
-0.017804326,
0.018009288,
0.0116486475,
0.0009488011,
-0.0126461275,
0.019211728,
0.0004778166,
-0.0077543785,
0.007822699,
0.028038738,
-0.021630274,
0.014661582,
-0.021206688,
0.014524941,
0.0040514064,
-0.0031598238,
0.021835236,
-0.015399444,
-0.0022272489,
-0.021657603,
0.014866544,
-0.02954179,
-0.016396923,
0.016055321,
-0.013910057,
0.0029497382,
-0.013472806,
0.01192193,
-0.020209208,
0.01582303,
0.017134786,
0.004901997,
-0.00342969,
0.003709804,
-0.019908598,
-0.017011808,
0.05162298,
-0.0032230204,
-0.017640356,
-0.0051377025,
0.039133992,
-0.03899735,
0.004741444,
0.012543647,
-0.0009880854,
-0.018364554,
-0.00159443,
-0.055776868,
0.0047311955,
-0.0069550285,
-0.022641419,
0.010698993,
-0.028202709,
-0.003052219,
-0.012400174,
-0.00006122159,
0.023051342,
-0.031208811,
0.004666291,
-0.02644004,
0.017271426,
-0.01531746,
-0.004225624,
0.0048439247,
0.0042392877,
0.016765853,
0.0341056,
0.011600823,
0.003723468,
-0.0065826816,
0.027259884,
0.004536482,
-0.00070071226,
-0.0126802875,
0.026248742,
-0.011976586,
-0.01658822,
0.005458809,
-0.024417752,
-0.013609447,
0.0047106994,
-0.006613426,
-0.0035048423,
0.014524941,
-0.0052709277,
0.02534691,
0.0332311,
-0.01575471,
-0.024855003,
-0.0072419746,
0.01805028,
-0.0058038277,
0.023515921,
-0.0057901638,
0.0004402403,
0.011860441,
0.008922659,
0.03743964,
0.008054988,
0.0077475463,
-0.023447601,
-0.048042987,
-0.017763333,
-0.00504547,
0.0020598634,
0.0086972015,
-0.011716968,
0.029733088,
0.01095861,
0.009851818,
0.0044066734,
-0.02891324,
-0.022709738,
-0.010794641,
0.010384718,
-0.012584639,
-0.029924385,
-0.028120724,
0.016396923,
0.0016806846,
0.010521359,
0.0047072833,
0.009715177,
-0.02277806,
0.003593659,
0.0024441665,
-0.007289799,
0.0012775937,
-0.016697533,
-0.0012912577,
0.017039137,
0.031427436,
0.0066202576,
0.0022289567,
0.032957815,
-0.008546896,
0.013431813,
-0.01222254,
0.021138366,
0.023502257,
0.006367472,
-0.021520961,
0.02001791,
0.01591868,
0.026699657,
0.001984711,
0.009756169,
-0.021029055,
-0.007351287,
0.0019385946,
-0.017148448,
-0.0034911784,
0.024991645,
-0.005609114,
-0.03716636,
0.00371322,
-0.014647918,
0.002526151,
0.009578536,
-0.0011537627,
0.01248899,
0.002667916,
-0.010842466,
-0.001587598,
-0.0016960568,
-0.02534691,
0.018774478,
0.018091273,
0.025538208,
0.012085899,
0.005667187,
0.018870126,
0.0051172064,
0.031400107,
-0.008239454,
0.018487532,
0.0023655978,
-0.0016115102,
0.0060668616,
-0.030197667,
-0.012536814,
-0.01318586,
0.014647918,
0.008089148,
0.0032435164,
-0.006374304,
0.088816665,
0.010541855,
-0.023666225,
0.0086630415,
-0.023884851,
0.0339143,
0.024035158,
-0.006791059,
-0.011464182,
-0.018815469,
0.00027285505,
-0.035116743,
0.012748608,
-0.03760361,
-0.03719369,
0.0027584408,
-0.007323959,
-0.0022238328,
-0.029432477,
0.0035287545,
0.026098436,
-0.003060759,
0.021466305,
-0.018200586,
-0.011826281,
0.015194482,
0.0054075685,
-0.0007468286,
-0.009045636,
-0.024964316,
0.0027072004,
-0.02467737,
-0.04938207,
0.009312086,
0.0024612464,
0.004311024,
-0.01062384,
-0.008881667,
0.04205811,
-0.015987,
0.024130806,
-0.0011016683,
-0.01941669,
-0.019444019,
0.008533232,
0.008376095,
-0.0072009824,
0.010207085,
-0.014948528
] |
The aim of this study was to determine trends in incidence, treatment and survival of colorectal cancer (CRC) patients with synchronous metastases (Stage IV) in the Netherlands. This nationwide population-based study included 160,278 patients diagnosed with CRC between 1996 and 2011. We evaluated changes in stage distribution, location of synchronous metastases and treatment in four consecutive periods, using Chi square tests for trend. Median survival in months was determined, using Kaplan–Meier analysis. The proportion of Stage IV CRC patients (n = 33,421) increased from 19 % (1996–1999) to 23 | [
0.0048440136,
-0.024904547,
0.018244028,
-0.033539526,
-0.017151494,
0.000010457193,
-0.029353669,
-0.0009378694,
-0.038725782,
0.019310238,
0.0060583074,
0.020073697,
0.0029222036,
0.00079307554,
-0.014492551,
0.01213636,
0.026049735,
-0.010458067,
-0.011945495,
-0.0043536886,
-0.023364468,
0.013478993,
-0.0085625835,
0.000786494,
-0.0055581103,
0.021350516,
0.020981949,
-0.038567822,
0.04030535,
-0.021258375,
0.008187436,
-0.004120044,
-0.024549143,
-0.019849924,
-0.030933239,
0.00786494,
0.012162685,
0.0003128288,
0.0014824918,
-0.014426735,
-0.015137542,
-0.009984196,
0.0031558485,
-0.0035671946,
-0.025891779,
0.0048571764,
0.01401868,
-0.025510048,
-0.014387246,
0.016480176,
0.01645385,
0.02880082,
-0.041516352,
-0.016901394,
0.016269566,
-0.0113136675,
-0.0015228038,
0.027879404,
-0.014268778,
-0.020231653,
0.01453204,
-0.015822021,
-0.024127925,
0.017375266,
-0.02880082,
-0.018480964,
-0.022166627,
-0.0053310473,
0.005633798,
0.036909275,
0.033486877,
0.026352486,
-0.025444234,
0.013235477,
0.026431464,
-0.0016618388,
-0.018007094,
0.007200205,
-0.0015466618,
-0.0013845915,
0.022587845,
-0.008194017,
0.013459249,
0.022364073,
0.027510837,
0.012096871,
-0.009200993,
0.00649598,
-0.011853353,
0.00089755753,
0.0223904,
0.026365649,
-0.0035079608,
-0.0072791832,
-0.0021274828,
0.005321175,
-0.0114716245,
0.036724992,
-0.010517301,
-0.04264838,
0.0069040353,
0.0039160163,
-0.028063687,
-0.015611413,
-0.021468984,
0.013926539,
-0.0004286228,
0.012254828,
0.02782675,
-0.0071804603,
-0.02474659,
0.03941026,
0.01888902,
-0.0050381687,
0.019086465,
-0.0077464725,
0.014834791,
0.00076181325,
-0.006509143,
-0.01782281,
0.005752266,
-0.018731063,
0.026391976,
-0.02701064,
0.017204145,
-0.004179278,
-0.028090013,
0.0002663467,
0.0083453925,
0.0049723536,
-0.013794907,
-0.002632616,
0.030827934,
0.025957594,
-0.003662627,
0.02077134,
0.0024335245,
0.011774375,
-0.04235879,
-0.0352244,
-0.005107275,
0.03604051,
0.005051332,
-0.01521652,
-0.017875463,
0.013432923,
0.024851894,
0.0017704342,
0.0029435938,
-0.011076732,
0.009543233,
-0.0147558125,
0.0001431485,
0.006936943,
0.009569559,
-0.009365532,
0.018757388,
0.013103846,
-0.0052915583,
-0.031696696,
-0.021784898,
0.010912193,
0.008950895,
0.014861117,
-0.008338811,
0.010260621,
0.030485693,
-0.0076609123,
-0.013005123,
-0.020876644,
0.009635375,
0.03919965,
-0.021705918,
0.027063292,
-0.0060583074,
0.008871916,
-0.036145817,
0.010326436,
-0.03962087,
-0.022706313,
-0.020692362,
0.027616141,
0.013952864,
0.0008095294,
-0.02974856,
0.0050842394,
0.013794907,
-0.002265695,
-0.013149917,
-0.011846771,
0.0064630723,
0.018770551,
0.02295641,
0.013281547,
-0.6343551,
-0.015071726,
0.0052027074,
-0.023983132,
0.012912981,
0.021811223,
0.0076477495,
-0.0036955348,
-0.04098983,
0.0027626015,
0.014058169,
0.029458974,
0.016216915,
-0.004248384,
-0.004337235,
-0.024246393,
-0.014413573,
0.008358556,
-0.014663671,
-0.005538366,
-0.0052718134,
0.013149917,
-0.011774375,
0.025628516,
-0.014150311,
-0.00015651724,
-0.00034614786,
-0.013051194,
0.00619652,
0.023614565,
-0.025483722,
0.02649728,
-0.00461695,
0.0027379205,
0.033355244,
-0.013926539,
-0.0146373445,
0.0055284933,
0.007851778,
0.030038148,
-0.011017498,
-0.0051862537,
0.02371987,
-0.00012258119,
-0.025154646,
0.042490423,
-0.008964057,
-0.012123196,
0.015427129,
0.0030439622,
-0.01654599,
-0.0019629444,
-0.024193741,
-0.0067724045,
0.009451091,
-0.014611019,
0.021087253,
-0.017875463,
-0.014110821,
0.016401198,
0.005508749,
0.00048415453,
0.000393247,
-0.010892449,
-0.03580358,
0.024206905,
-0.023048554,
-0.009510325,
0.009806494,
0.011892843,
0.018994324,
0.03022243,
0.015611413,
-0.0046103685,
0.049545832,
0.018770551,
0.012636556,
0.018665247,
-0.0147558125,
0.00363301,
0.0041595334,
0.009405021,
-0.02432537,
-0.00010571598,
0.030354062,
0.011010916,
-0.03488216,
0.0014306622,
0.010379088,
0.028484905,
0.018020255,
0.02478608,
-0.0077069835,
0.000148496,
0.015005911,
0.03825191,
0.0060714707,
0.015901001,
0.01042516,
-0.02824797,
-0.035066444,
-0.011859935,
0.020179002,
-0.011695396,
0.006499271,
-0.0030669975,
-0.043780405,
0.00367579,
0.014624182,
-0.02077134,
-0.0020188873,
-0.019652478,
-0.007042248,
-0.021060929,
-0.0073647434,
-0.021561125,
-0.0024598506,
0.02560219,
-0.020889807,
-0.0072199493,
0.02859021,
-0.01093852,
0.021126743,
0.007108063,
0.009082525,
-0.0029518206,
0.01833617,
-0.0025207298,
0.016098447,
-0.0022229152,
0.0039423425,
-0.020837156,
0.029511625,
-0.014071332,
-0.007081737,
-0.034355637,
0.01350532,
-0.015650902,
-0.0272739,
-0.034329314,
-0.036382753,
0.009161504,
-0.00014222297,
-0.0065486324,
-0.0030291537,
-0.010839797,
-0.010504138,
-0.004337235,
-0.0025141484,
0.0037416054,
-0.014992748,
-0.004867049,
0.008957475,
-0.0057950458,
0.018625759,
0.0013557972,
0.0020830573,
-0.017296286,
-0.019099629,
-0.018151887,
0.017019862,
-0.0077201463,
-0.009075943,
-0.0060714707,
-0.0033138054,
-0.025589027,
-0.016256403,
0.036277447,
0.0043109087,
-0.015624576,
-0.005005261,
-0.009306298,
-0.007943919,
-0.010326436,
-0.000765104,
-0.0018790297,
-0.0283796,
-0.019507684,
0.0015762788,
-0.0036823717,
0.037409473,
0.008029479,
0.0023331558,
-0.014123985,
0.03654071,
0.027168596,
0.045939147,
-0.020652872,
-0.007292346,
0.011517695,
-0.0002188362,
0.024259556,
-0.015993143,
0.023298651,
0.013531646,
0.0012932726,
-0.029590603,
0.004123335,
0.021311026,
0.026655236,
0.044938754,
0.016190588,
0.014663671,
0.008707377,
0.004050938,
0.010872704,
0.012629976,
0.008450697,
0.04375408,
-0.00081981305,
0.016164262,
-0.0147953015,
-0.0037416054,
-0.0021291282,
0.00075276365,
0.021982344,
0.00044055184,
-0.025062503,
-0.0068316385,
0.011339993,
-0.020179002,
-0.016203752,
0.024443839,
0.018757388,
-0.010234294,
-0.007292346,
0.01850729,
0.020889807,
0.0006236009,
-0.0076609123,
-0.031433433,
0.031091195,
0.020679198,
0.021705918,
0.038646802,
0.015137542,
0.018586269,
-0.010629187,
0.019468196,
0.006219555,
0.008917986,
0.018230865,
0.016769763,
0.003577067,
0.001104876,
-0.0020715396,
0.023825174,
0.023232836,
0.009813076,
0.003962087,
-0.009503744,
-0.005163218,
-0.021271538,
0.0019448451,
0.008858752,
-0.014426735,
-0.0024220068,
0.01607212,
0.043648772,
0.011300504,
0.030590998,
0.005048041,
0.009089107,
-0.0038304562,
-0.019033814,
0.0075161187,
-0.02782675,
0.005031587,
-0.00063018245,
-0.016717112,
0.006469654,
-0.01645385,
0.016967209,
-0.036961928,
-0.010227713,
-0.006022109,
0.01799393,
-0.0057654288,
-0.0023265744,
0.023654055,
-0.005949712,
-0.035619292,
0.009010128,
0.0041430793,
-0.011399227,
-0.039805155,
-0.0050447504,
0.026773704,
-0.005403444,
0.0019711712,
0.017849136,
0.039857805,
-0.022074485,
0.0007507069,
-0.014097659,
-0.008233506,
0.028405927,
-0.030406715,
0.008746866,
0.003060416,
-0.006525597,
0.021692755,
0.013794907,
-0.014242453,
0.027879404,
0.0005372182,
-0.0023808721,
-0.036988255,
-0.03264444,
-0.012261409,
0.0028991683,
-0.01597998,
-0.022614172,
0.015400804,
0.005153346,
0.0073318356,
0.013742255,
-0.0013179533,
0.028985102,
-0.016875068,
-0.014953258,
-0.012590486,
-0.005837826,
-0.01734894,
0.029432647,
0.023443446,
0.0131630795,
0.0059727477,
0.036961928,
-0.0010991172,
-0.0021636812,
-0.018191377,
0.018217703,
-0.0005627217,
0.010879286,
-0.002811963,
0.0145978555,
0.0099381255,
-0.00418915,
0.018099235,
-0.008839008,
-0.011109639,
-0.003991704,
0.020455426,
-0.004850595,
-0.015677229,
0.046649955,
0.03722519,
0.02427272,
-0.029379994,
0.010576535,
0.0131433355,
0.008398045,
-0.022285094,
-0.009010128,
0.017033026,
0.004922992,
0.03735682,
-0.01098459,
-0.004024612,
0.022574682,
-0.007799125,
-0.0070554106,
-0.006469654,
0.01769118,
-0.0034947977,
0.0221403,
0.011629581,
0.043780405,
-0.020100024,
0.00043890646,
0.0083453925,
0.01812556,
-0.0041266256,
0.02914306,
-0.0068974537,
0.001062096,
-0.004992098,
-0.000024295137,
0.014295105,
-0.0035145422,
-0.00037370806,
-0.0167566,
-0.0035935207,
0.019889414,
-0.03543501,
0.007423977,
0.0043405257,
-0.02735288,
0.0128866555,
-0.038515173,
-0.033118308,
-0.006811894,
-0.014821628,
-0.009010128,
-0.01978411,
0.011820446,
-0.005903641,
0.014347757,
0.00096913177,
0.02529944,
-0.024206905,
-0.022706313,
0.012373295,
-0.0024170706,
0.015321825,
-0.009312879,
-0.013413179,
-0.0073055094,
0.0012159395,
0.0061010877,
-0.02248254,
-0.021824386,
0.049940724,
0.009595885,
-0.0129064,
-0.0071804603,
-0.00918783,
-0.019639315,
-0.013419759,
0.0073779062,
0.011998148,
-0.018520454,
-0.004518227,
0.003662627,
-0.010741073,
-0.034645226,
-0.026523607,
-0.016401198,
-0.016993536,
0.0072067864,
0.010517301,
-0.021771735,
-0.026234018,
0.009312879,
-0.01734894,
0.0076806573,
-0.007970245,
0.016058957,
0.0056765783,
-0.03153874,
0.015782533,
0.024430675,
0.015400804,
0.010773981,
0.02333814,
0.013005123,
-0.015400804,
-0.029195711,
-0.0030867422,
-0.004238512,
-0.017849136,
-0.044385906,
-0.0099973595,
-0.0029518206,
0.03064365,
-0.016717112,
-0.05128336,
-0.016651295,
-0.0038600732,
0.017520059,
0.0086415615,
-0.012518089,
-0.0335132,
-0.012294317,
0.0145583665,
-0.012893237,
-0.038620476,
0.0060155275,
-0.021482145,
0.00453139,
-0.0076477495,
0.00363301,
-0.01124127,
0.012708954,
-0.012774769,
0.011129384,
0.0059826197,
-0.0016552573,
-0.021561125,
-0.017704342,
-0.009931544,
0.024693938,
0.039541893,
0.00735158,
0.006064889,
0.022627335,
-0.0027856368,
0.022456214,
-0.008325648,
-0.027905729,
0.014110821,
0.013452668,
0.025009852,
0.014453062,
-0.00363301,
-0.0049526086,
0.014545203,
0.01790179,
0.019204933,
-0.0020057242,
-0.008760029,
-0.014268778,
-0.027405532,
-0.027431859,
-0.0060254,
-0.00042080722,
0.015901001,
-0.03243383,
-0.004811106,
0.0065815398,
0.013156499,
0.0083783,
-0.018244028,
0.03482951,
0.004465575,
0.014308268,
-0.004547844,
0.008898242,
0.009168085,
-0.0020057242,
-0.026260344,
-0.0052849767,
-0.010793725,
-0.0068448014,
0.025062503,
0.023969969,
-0.011767793,
0.016058957,
-0.0041430793,
-0.057285722,
-0.0039028532,
-0.014887444,
-0.015295499,
0.0038699454,
-0.0040673916,
0.014150311,
-0.0070883185,
-0.018546779,
0.015743043,
-0.00641042,
0.0068316385,
-0.0075227004,
-0.007068574,
0.02491771,
-0.01816505,
0.0070027583,
-0.01923126,
0.020231653,
0.011820446,
-0.01166907,
-0.0016725338,
-0.0068316385,
-0.014347757,
-0.0059826197,
0.03235485,
0.033776462,
0.0059266766,
-0.014123985,
0.0073449984,
0.0115703475,
-0.018257191,
-0.052073143,
0.014716323,
0.032381177,
0.0117480485,
-0.035329707,
-0.0008309194,
-0.035961535,
0.035487663,
-0.0129853785,
-0.011149129,
0.00076469267,
0.0054264795,
-0.019389216,
0.022916922,
-0.025286276,
0.015045401,
-0.019297075,
-0.021982344,
-0.013307874,
-0.007127808,
-0.011333412,
0.00048579992,
0.010181642,
0.015545597,
-0.0004109349,
0.0038436193,
0.00019394976,
0.009214156,
-0.016848743,
-0.004692638,
-0.040252697,
0.039436586,
-0.008200599,
-0.0040114485,
-0.0020616674,
0.023746196,
0.0035013792,
-0.009832821,
0.0025503468,
-0.022219278,
-0.026102388,
-0.011859935,
0.025115157,
0.029669583,
0.00009795182,
-0.004521518,
-0.0025223752,
0.010023685,
-0.023956805,
-0.0017292997,
-0.00020042846,
-0.057075113,
-0.01363695,
-0.02303539,
0.014242453,
0.026786868,
0.0054133167,
-0.0002478361,
-0.0052882675,
0.029853866,
-0.0229959,
0.005061204,
0.008187436,
0.005005261,
0.002932076,
0.02081083,
-0.019731456,
-0.033618506,
0.026418302,
0.00013379037,
-0.009372113,
-0.017072514,
-0.0025865452,
-0.017704342,
0.013031449,
-0.025707494,
0.0041002994,
0.018652083,
-0.0062886616,
-0.008819263,
-0.008740285,
0.034566246,
-0.021653267,
0.021403167,
0.0059299674,
0.0065124338,
0.019468196,
-0.018494127,
0.008707377,
-0.0017342358,
-0.020508079,
-0.017085677,
-0.013729093,
0.03285505,
-0.011524277,
0.017085677,
-0.019323401,
-0.0061767753,
-0.020995112,
0.0006425228,
-0.0069566877,
-0.02457547,
0.011418972,
0.011010916,
0.005117147,
0.0145978555,
-0.009602467,
-0.017559549,
-0.01307752,
-0.010852959,
-0.01580886,
0.0062689167,
-0.020060534,
0.024351697,
0.014887444,
0.012807677,
-0.03248648,
-0.026655236,
-0.023443446,
-0.01949452,
0.0038600732,
0.036303774,
0.010504138,
0.031696696,
-0.0072331126,
0.030880585,
-0.0054462245,
0.0040377746,
-0.01867841,
-0.009398439,
0.015664065,
-0.013992354,
0.02590494,
-0.0024713683,
-0.02431221,
0.00841779,
0.015848348,
0.019389216,
-0.020455426,
0.0131235905,
-0.025233625,
-0.004521518,
0.006910617,
-0.017756995,
-0.016901394,
0.0012480245,
0.009385276,
-0.032170568,
0.0048604673,
0.016348545,
0.002410489,
0.021903364,
-0.0005368068,
-0.0020550857,
0.03235485,
-0.0012924499,
-0.009852565,
-0.026220854,
0.017546386,
-0.025049342,
-0.0009181248,
0.028642861,
0.02748451,
0.01632222,
0.016006306,
0.020587057,
-0.013939702,
0.0041430793,
-0.014505714,
-0.03182833,
0.005025006,
-0.023364468,
-0.0012809322,
0.0102737835,
-0.011741467,
0.012057381,
-0.022429887,
-0.02782675,
-0.035198074,
-0.0131828245,
0.03867313,
0.0030324445,
-0.012761606,
0.0020847027,
0.025141483,
-0.051783558,
-0.0023874536,
-0.02487822,
-0.016875068,
-0.024154251,
-0.008654725,
-0.028642861,
0.018915346,
0.006351186,
0.0065321783,
-0.018638922,
-0.018401986,
0.0017753704,
0.1887059,
0.0028530976,
0.0007046361,
0.022601008,
0.008187436,
-0.015334988,
0.041516352,
0.00615374,
-0.0064630723,
0.026431464,
0.019652478,
-0.02371987,
0.002372645,
0.012221919,
0.019165445,
0.006877709,
-0.015124379,
-0.02649728,
-0.002705013,
0.00030809833,
0.0025042759,
-0.001773725,
-0.0070949,
-0.019731456,
-0.005992492,
-0.0039719595,
-0.0011040533,
0.005205998,
0.028616536,
0.014031843,
0.00039345268,
-0.007410814,
1.671094e-7,
0.012333806,
-0.0117085595,
-0.0070883185,
-0.0117085595,
-0.02748451,
-0.014663671,
0.010635769,
-0.011827027,
0.0076214233,
-0.0358299,
-0.02803736,
-0.007443722,
0.016993536,
0.001979398,
0.005999074,
-0.01944187,
0.00026572967,
-0.037409473,
-0.014045007,
0.022745801,
0.010063174,
-0.00030110547,
-0.0015902646,
0.018849531,
-0.009075943,
-0.00077950116,
0.019547174,
0.004393178,
-0.01521652,
-0.0020633128,
0.010734492,
-0.015848348,
0.041174114,
-0.016374871,
0.0040114485,
-0.0023232836,
-0.01226799,
0.020007882,
-0.018099235,
-0.0070159216,
-0.023009064,
0.011859935,
-0.019823598,
0.014992748,
0.035487663,
0.0020452135,
0.035566643,
0.01521652,
-0.016954048,
0.004050938,
0.014808465,
-0.03580358,
-0.020823993,
0.0029929553,
0.009990778,
-0.0018527035,
-0.012643138,
-0.012386458,
0.012294317,
-0.008411208,
-0.00015086123,
0.023588238,
0.025167808,
0.01384756,
0.026089225,
0.0016075411,
-0.0057358122,
-0.013794907,
0.06760558,
0.0184678,
0.0071738786,
0.005893769,
0.0029814376,
-0.023930479,
0.014663671,
0.011465043,
-0.0184678,
0.02880082,
-0.023351304,
0.0062129735,
-0.011254434,
0.017375266,
0.027300227,
-0.0073318356,
-0.026957987,
0.008917986,
0.00052940263,
0.010122408,
-0.0385415,
0.010411996,
0.04278001,
-0.03646173,
-0.041674312,
-0.011787538,
-0.023088042,
-0.015321825,
-0.009095688,
0.0016322219,
-0.019428706,
0.008628399,
0.0064466186,
-0.0016404488,
-0.019033814,
-0.0004598851,
-0.023943642,
-0.030459367,
0.0038271656,
0.018178213,
0.0007383665,
-0.0146373445,
0.01021455,
-0.0054725506,
-0.024562307,
-0.008233506,
0.0038403287,
-0.02431221,
-0.016480176,
-0.010635769,
-0.020100024,
-0.011517695,
0.01607212,
0.02192969,
-0.020165838,
-0.014295105,
-0.04154268,
0.0031426854,
0.026128713,
-0.02735288,
-0.0060583074,
0.021495309,
-0.030038148,
-0.009431346,
0.026826357,
-0.16522297,
0.006064889,
0.010905611,
-0.015782533,
0.0013113718,
0.0009971033,
0.0036955348,
0.0051138564,
-0.008068968,
0.004304327,
0.0145188775,
0.012794513,
-0.044622842,
-0.017335776,
-0.00068982766,
0.01047123,
-0.01367644,
0.026023408,
0.04504406,
0.0085033495,
0.030248757,
-0.022495704,
0.00910227,
-0.05025664,
-0.012662883,
0.012346969,
-0.007667494,
0.0012340387,
-0.0060550165,
-0.021403167,
-0.014321431,
0.012511508,
0.00448861,
-0.025036179,
-0.013472412,
0.004820978,
-0.036172144,
-0.024457002,
-0.0043174904,
-0.012814258,
0.0028317075,
0.01795444,
0.006818475,
-0.0054297703,
-0.022772128,
0.025259951,
0.016414361,
-0.011142547,
0.025496885,
0.007476629,
-0.0032002737,
0.0015359669,
0.016058957,
0.002940303,
-0.0033450676,
0.011787538,
0.011228107,
-0.016598644,
0.007937337,
0.005222452,
-0.0056436704,
-0.037383147,
0.025365256,
0.0038666548,
-0.018967997,
-0.032381177,
0.001006153,
0.01888902,
-0.019323401,
0.024654448,
-0.018573105,
0.024457002,
-0.010616024,
-0.017033026,
0.034855835,
0.011280759,
0.009457673,
0.01898116,
-0.006637483,
-0.0009913445,
-0.0116493255,
0.029643256,
-0.011807282,
0.0012422657,
0.017533222,
0.012577323,
0.01457153,
0.017256798,
0.010971427,
-0.016203752,
0.001380478,
-0.035487663,
0.016532829,
-0.022311421,
0.02244305,
0.028221643,
-0.0050151334,
0.0038074208,
0.00619652,
-0.02611555,
0.013215732,
-0.020692362,
-0.025180971,
0.012899818,
0.02748451,
0.012077126,
-0.00534421,
0.002538829,
0.02431221,
-0.014202964,
-0.022192953,
-0.00534092,
0.008332229,
-0.01098459,
0.0024203614,
0.0195735,
-0.0012611876,
-0.011287341,
-0.0037942578,
0.0023183473,
0.043833055,
-0.0116493255,
-0.0034553085,
-0.013301292,
0.023825174,
0.0032891247,
-0.108569086,
-0.008496768,
0.013794907,
0.033276267,
0.0048143966,
0.03859415,
-0.011840191,
-0.001104876,
-0.025707494,
0.043833055,
-0.013794907,
-0.010912193,
-0.0024565598,
0.01470316,
0.033328917,
-0.0044820285,
0.013808071,
-0.016203752,
-0.000018741963,
0.021495309,
0.012715535,
0.0014290168,
0.010109246,
-0.037330493,
-0.0018362496,
-0.012057381,
-0.01709884,
0.0031476214,
0.0037942578,
0.016532829,
0.008259833,
-0.011774375,
-0.002354546,
-0.00045165818,
-0.02735288,
0.0034454362,
-0.026892172,
-0.019349728,
0.024417514,
-0.03996311,
0.006314988,
0.016374871,
0.0076214233,
0.0045741703,
0.010721329,
-0.008272995,
-0.030275084,
-0.0038732362,
0.028563883,
0.006650646,
0.0042944546,
-0.0049526086,
-0.009510325,
-0.01867841,
-0.0065124338,
-0.012755024,
0.017493732,
0.01576937,
-0.016440686,
0.006120832,
-0.015492945,
-0.001953072,
-0.03482951,
0.020797666,
0.0059859105,
-0.000083349034,
-0.017506896,
-0.0019004197,
0.01837566,
-0.002367709,
-0.030933239,
0.0020452135,
-0.031591393,
-0.0033862023,
-0.02090297,
0.010227713,
-0.017743832,
-0.005393572,
0.0204291,
-0.02354875,
-0.0025059213,
-0.019297075,
0.018546779,
-0.011234689,
0.02722125,
0.016927721,
-0.010912193,
-0.0070619923,
-0.004054229,
-0.003488216,
0.004291164,
0.04278001,
0.004149661,
-0.005992492,
0.018731063,
0.017493732,
-0.0056996136,
-0.005979329,
0.006002364,
0.021574289,
-0.023232836,
-0.006736206,
-0.057022464,
0.01367644,
0.022245605,
-0.022785291,
0.014281942,
-0.0043800147,
0.030038148,
-0.0067724045,
0.022048159,
0.0047946516,
-0.009286553,
0.026602585,
-0.016006306,
0.0012521379,
-0.013057775,
0.022614172,
-0.007496374,
0.02196918,
0.020837156,
0.03222322,
-0.0066407737,
0.0037712224,
0.019099629,
0.0120508,
0.01572988,
0.0053573735,
0.01679609,
0.03580358,
-0.03359218,
-0.017046189,
0.027405532,
-0.0029567569,
-0.013110427,
0.014466225,
-0.0021932982,
-0.0272739,
0.020731851,
0.027089618,
0.018862693,
0.0335132,
-0.005709486,
-0.017151494,
0.022100812,
-0.010773981,
-0.00884559,
0.008167691,
0.006166903,
0.024088437,
-0.022271931,
0.008233506,
0.012860329,
-0.004893375,
0.01841515,
-0.024338534,
-0.01538764,
-0.00004645642,
0.007338417,
0.005449515,
-0.016361708,
-0.049703788,
0.023785686,
0.01765169,
0.0054560965,
0.012412785,
0.017296286,
-0.010793725,
-0.006621029,
-0.023798848,
-0.0030390262,
-0.020100024,
-0.0085230945,
-0.008582328,
0.01098459,
0.0143609205,
-0.0065881214,
-0.014071332,
-0.020455426,
0.02354875,
0.011807282,
-0.0007782671,
0.0033582307,
-0.0012447337,
-0.005192835,
0.023969969,
0.02145582,
0.007628005,
-0.017928114,
0.03201261,
0.0047946516,
-0.0019497812,
0.0017144912,
0.012096871,
-0.00010278515,
-0.0017144912,
-0.006469654,
0.02077134,
-0.016098447,
0.0067987307,
0.032828722,
0.02145582,
-0.025589027,
-0.0084638605,
-0.015492945,
-0.019310238,
-0.017849136,
0.005591018,
-0.00053927494,
-0.03935761,
0.00010155111,
0.021179395,
0.023772523,
0.020823993,
-0.0023430283,
-0.0046432763,
0.0038863993,
-0.006943525,
-0.0012990314,
0.0056765783,
-0.006499271,
0.018007094,
0.0047946516,
0.012017892,
0.010866122,
-0.009141759,
-0.002431879,
-0.008746866,
0.006384094,
-0.019599825,
0.018665247,
-0.003030799,
0.0049855164,
-0.007200205,
-0.029090406,
-0.012221919,
-0.022916922,
-0.0024763043,
0.009674864,
-0.01970513,
0.011813864,
0.08713959,
0.013261803,
-0.023706706,
0.010458067,
-0.030669976,
0.013689603,
0.024009457,
0.0037712224,
-0.008556002,
-0.05159927,
-0.0070159216,
-0.018388823,
0.007140971,
-0.053152516,
-0.002295312,
0.017046189,
0.0069040353,
0.017704342,
-0.0049986797,
-0.008068968,
0.0084836045,
-0.01662497,
-0.013531646,
0.0022377237,
0.0014323076,
-0.0016322219,
0.025352092,
0.006423583,
-0.009543233,
-0.04133207,
-0.008760029,
-0.017006699,
-0.025668006,
-0.018296681,
0.015756207,
-0.009207575,
0.0036527547,
-0.047071174,
0.015440293,
0.0058312444,
-0.019507684,
0.004449121,
-0.0115703475,
0.0043207807,
-0.011761212,
-0.008009734,
-0.008983802,
-0.021771735,
-0.005150055
] |
Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein–Barr virus (EBV) was discovered in BL tumours soon after. Since then, the role of EBV in the development of BL has become more and more enigmatic. Only recently have we finally begun to understand, at the cellular and molecular levels, the complex and interesting interaction of EBV with B cells that creates a predisposition for the development of BL. Here, we discuss the intertwined histories of EBV and BL and their relationship to the cofactors in BL pathogenesis: malaria and the | [
-0.03177566,
-0.016404929,
-0.0018922548,
-0.033792343,
-0.009902423,
-0.0015440218,
-0.0012200277,
-0.0013452623,
-0.020994172,
0.009611555,
-0.02505339,
-0.0020247612,
0.009831322,
0.017038373,
-0.019145546,
0.0032447889,
0.030250221,
0.0013888924,
0.006075899,
0.0053422665,
-0.053002525,
0.01684446,
0.011227486,
-0.03239618,
-0.015163893,
0.02413554,
0.017348632,
-0.041729793,
-0.016585913,
0.008325275,
0.005710699,
-0.0015876519,
0.0012539622,
0.00034883904,
-0.015293168,
-0.020128032,
0.0031284417,
-0.013535035,
0.028104266,
0.00053770095,
0.006470186,
0.026630538,
-0.015474152,
0.01710301,
-0.014013351,
0.009824858,
0.0067222714,
-0.0120289875,
0.0020780868,
0.015913686,
0.003354672,
-0.0022671507,
-0.001699959,
0.0066123884,
-0.014194335,
-0.020309016,
-0.0008782583,
0.0056525255,
-0.0028505016,
-0.027897427,
0.0016708723,
-0.0077693947,
-0.002679213,
-0.002168579,
-0.0048380964,
0.019300675,
-0.0025321634,
0.02054171,
0.014013351,
0.020464147,
0.019287748,
0.028647218,
0.0023334038,
0.0077952496,
0.030638045,
0.01272707,
-0.024342379,
-0.005988639,
-0.015396588,
0.022377407,
0.0020053699,
0.0071424134,
0.0011497347,
0.026384916,
0.009811931,
-0.014039205,
0.02236448,
0.014801925,
0.002960385,
0.00035045497,
0.0014995836,
0.01644371,
0.016223943,
0.010606969,
-0.0030605725,
0.019585079,
-0.00043872517,
0.04514264,
0.020153888,
-0.044573832,
-0.017245213,
0.0016345138,
-0.011544209,
-0.017852802,
-0.019843629,
0.0020086018,
0.023502095,
-0.017271066,
0.01543537,
-0.00021269688,
-0.03304255,
0.016211016,
-0.0100704795,
-0.045427043,
0.03609343,
0.002354411,
-0.002958769,
-0.009049212,
0.0012798171,
-0.012158263,
0.008131363,
0.0109043,
-0.0059078424,
-0.023398675,
0.041678082,
-0.007672439,
-0.03415431,
-0.017865729,
0.014336537,
-0.011725193,
0.0075884103,
0.027380329,
-0.021640543,
-0.0077435398,
-0.012791707,
-0.0026275031,
-0.02028316,
-0.018964563,
0.0016789519,
0.01272707,
0.005610511,
0.033792343,
-0.0063021295,
-0.005109573,
-0.007200587,
0.028854057,
0.0007808985,
0.024057975,
0.0062084054,
-0.016004177,
-0.0072587603,
-0.02151127,
0.043927457,
-0.012836953,
-0.003988117,
0.00956631,
-0.021666398,
0.04532362,
-0.024226032,
-0.018899925,
-0.0073492527,
-0.0015165509,
0.024536291,
0.020515855,
0.026436625,
0.046176836,
-0.012087162,
0.0005053823,
0.0062795067,
-0.015125111,
0.0104001295,
0.0380584,
-0.035938296,
0.0142977545,
-0.0015496775,
0.011033574,
0.009747294,
0.014543376,
-0.03345623,
-0.014918271,
-0.012274609,
0.018783579,
0.025557559,
-0.0070002116,
-0.033585504,
0.0047249813,
0.009430571,
-0.032318614,
-0.0048574875,
-0.014840707,
-0.0077758585,
0.0035356563,
0.013315269,
-0.020903679,
-0.6395466,
-0.02054171,
0.009456426,
0.015060473,
-0.0031365214,
-0.006942038,
0.0021508038,
-0.025221447,
-0.017335704,
0.020140959,
-0.023812354,
0.0026856768,
0.013651382,
-0.008648461,
-0.0034419324,
-0.030017529,
-0.0064604906,
-0.005077254,
0.020244379,
-0.0120289875,
-0.011731656,
0.01659884,
-0.0070196027,
0.01781402,
-0.018718941,
-0.0035776705,
0.021550052,
-0.006573606,
0.017180575,
0.036248557,
0.0022267525,
0.022118859,
-0.0077887857,
-0.0070389938,
0.03870477,
-0.0040689134,
-0.00442765,
0.018550884,
0.01618516,
0.025686834,
0.020813188,
-0.021459559,
-0.011550672,
-0.009495209,
-0.014427029,
0.019507514,
0.005216224,
-0.0027697051,
0.014969981,
-0.0006625316,
0.001561797,
0.008273565,
-0.0074785273,
-0.01583612,
0.009049212,
0.012752925,
0.006315057,
-0.024226032,
0.013192458,
-0.018861143,
-0.0190292,
0.013166603,
-0.010354884,
0.0009841018,
-0.008170146,
0.0133281965,
-0.032111775,
0.018344045,
0.0067675174,
0.01052294,
0.031155143,
0.022739377,
-0.007762931,
0.008551505,
0.0136126,
0.023928702,
0.0013226393,
-0.0043048393,
-0.020968316,
-0.013819439,
-0.017141793,
-0.0074009625,
-0.02970727,
0.002191202,
0.02529901,
-0.019791918,
-0.013405761,
0.010833199,
0.008208928,
0.005103109,
0.0012127559,
0.003939639,
-0.018344045,
-0.011576527,
-0.016211016,
0.013089038,
-0.011835076,
-0.0013242551,
0.015396588,
-0.021485414,
-0.014711433,
-0.013897004,
0.0024335915,
-0.0013169835,
0.010787953,
0.013599672,
-0.019585079,
-0.0073298616,
0.04478067,
-0.038575497,
-0.003149449,
0.002496613,
0.0035744386,
0.0019698194,
0.022454971,
-0.022131786,
0.017322777,
0.011692874,
0.015551717,
-0.013897004,
0.009786076,
0.016831534,
0.0076336563,
-0.028130122,
0.0026905246,
0.016792752,
-0.002585489,
-0.016236871,
-0.011776903,
-0.011266269,
-0.009585701,
-0.003823292,
0.037101768,
-0.0138582215,
0.034826536,
-0.0014616093,
0.028311105,
-0.000022888144,
-0.015319022,
-0.021032954,
-0.040695596,
-0.013703092,
0.008448086,
0.0272252,
-0.025841963,
-0.013819439,
0.010051088,
-0.0060952906,
-0.017335704,
0.0007748387,
0.03818767,
-0.0070325304,
-0.030172657,
0.0077952496,
0.037567157,
-0.0011222638,
-0.014414102,
-0.022390336,
-0.004059218,
-0.012054843,
0.004401795,
0.005946625,
0.010432448,
0.0017613644,
0.023876991,
-0.0026032643,
0.0047669956,
0.015965395,
0.0024190482,
-0.05424356,
0.011292123,
0.005655757,
-0.0071359496,
0.015034619,
-0.010594041,
0.0055070915,
-0.0060274214,
-0.014556304,
-0.013050256,
-0.0081507545,
0.009049212,
0.0056589893,
0.0052388473,
0.009883032,
0.027406184,
0.015422442,
0.006890328,
-0.0049996893,
0.023838209,
0.027199345,
0.0058496688,
0.02418725,
-0.015642209,
0.019701427,
0.016585913,
-0.0063699987,
-0.010464767,
0.024807768,
0.011486035,
0.037877414,
-0.005196833,
-0.0060855947,
0.01599125,
0.0056040473,
0.0117187295,
-0.02104588,
-0.001420403,
-0.025932455,
0.012914518,
0.018809432,
0.0021588833,
-0.00033267972,
-0.00016755181,
-0.0033837587,
0.0028278786,
0.0029636167,
-0.018951634,
-0.005439223,
-0.021524196,
-0.014582158,
-0.024200177,
0.019662645,
0.007297543,
-0.003471019,
0.0046797353,
0.020050468,
0.013987496,
0.016624695,
-0.010341956,
-0.0057850317,
0.0064895777,
0.011673483,
0.020360727,
0.0042466656,
0.0015561412,
0.006618852,
0.0113890795,
-0.019688498,
0.043539636,
0.013095502,
-0.025777325,
0.01533195,
-0.00074857986,
0.016572984,
0.016417855,
0.0004173141,
0.019766064,
0.011014183,
-0.01262365,
0.025854891,
-0.021718107,
0.01189325,
-0.0059724795,
-0.000015679578,
-0.017633036,
-0.021162229,
-0.005335803,
-0.0008685627,
0.032861564,
0.006147,
0.012597796,
-0.021627616,
0.008305884,
-0.008545041,
-0.0048833424,
0.0075884103,
-0.0055749607,
-0.023489168,
-0.014207263,
0.014181407,
-0.024109686,
-0.019145546,
0.017943295,
-0.036170993,
0.025363648,
0.021860309,
-0.004650648,
0.008952255,
0.0064798817,
-0.0010745939,
-0.03891161,
-0.020658057,
0.0053454987,
0.006292434,
-0.013522108,
-0.011576527,
0.004388868,
-0.012714142,
-0.0060209576,
-0.010813808,
0.010568187,
0.005804423,
-0.003425773,
0.0061373045,
0.0016579449,
-0.009811931,
0.002305933,
-0.009197878,
0.0078211045,
-0.0045957067,
0.0065348237,
-0.0035033377,
-0.01811135,
-0.009372397,
0.008538578,
0.0016159307,
0.0016450174,
-0.009954133,
-0.0088811545,
-0.019740209,
-0.021950802,
-0.03131027,
-0.0044405772,
0.0013379906,
-0.013728946,
0.0306639,
0.026152221,
0.025273155,
-0.010988329,
0.0066447067,
-0.03779985,
-0.048995018,
-0.019921193,
-0.024523364,
0.05610511,
0.016702259,
-0.02675981,
0.024613855,
0.013806512,
0.0021798904,
-0.012836953,
-0.040049225,
0.023385748,
0.012087162,
0.005597584,
-0.0033869906,
-0.0009299681,
0.015474152,
0.012946837,
0.01467265,
-0.011143458,
-0.0154870795,
0.020877823,
0.0053228755,
0.0021491877,
0.009999379,
0.012895127,
0.049667243,
-0.00093562383,
-0.007194123,
-0.007569019,
0.013134284,
-0.00096067076,
-0.0056460616,
-0.006916183,
0.013741874,
-0.0010527788,
0.028647218,
-0.0066382433,
-0.02231277,
-0.0067416625,
0.027535459,
0.0060403487,
0.003149449,
0.03606757,
0.017982077,
-0.0034063817,
0.004098,
-0.00025269116,
-0.0045052147,
0.011970814,
-0.007943915,
0.021175155,
-0.009475817,
0.044366993,
-0.013819439,
0.0018340813,
-0.00069121434,
0.0067028804,
0.0055781924,
0.0048348643,
-0.009437035,
-0.013173067,
-0.0030427973,
-0.013522108,
-0.018421609,
0.029914109,
-0.0067675174,
0.02939701,
-0.010477695,
-0.0066576344,
-0.0023220924,
-0.0055297147,
-0.028000847,
0.00074494403,
-0.027457893,
-0.036713943,
0.0042337384,
0.0096503375,
0.02479484,
0.008099045,
-0.006877401,
-0.002653358,
0.005358426,
-0.007685366,
0.006735199,
0.001840545,
-0.028698929,
-0.006786909,
0.012106553,
0.022881579,
-0.023204764,
-0.010833199,
-0.0015989634,
-0.0231272,
0.012436203,
0.0014826164,
0.0054424545,
-0.0028052556,
0.02469142,
0.0068127634,
0.03193079,
-0.012811098,
-0.0067028804,
-0.0052259197,
-0.021485414,
-0.0028488857,
-0.0014947358,
-0.00974083,
-0.012403884,
-0.006496041,
0.00731047,
-0.031206854,
-0.02069684,
0.012378029,
-0.015952468,
0.02038658,
-0.004783155,
0.01800793,
0.03562804,
0.01085259,
-0.0071036313,
0.030250221,
-0.023269402,
-0.011899713,
-0.013037329,
0.015112183,
-0.016896171,
-0.011098212,
0.0035809022,
0.01816306,
-0.024924114,
-0.015099256,
-0.023153054,
-0.0015795722,
0.02170518,
0.014052133,
-0.0010414673,
-0.03526607,
0.0056654527,
0.013573818,
0.009327152,
-0.004453505,
-0.02635906,
0.009204341,
0.01715472,
0.010606969,
-0.014258972,
0.021614688,
-0.03679151,
-0.001585228,
0.037567157,
-0.009611555,
-0.0020457683,
-0.015215603,
0.0010616664,
-0.021731036,
-0.006547751,
-0.006967893,
-0.016055888,
-0.010943082,
-0.009676193,
0.047185175,
0.023101345,
0.036351975,
-0.019520443,
0.024316525,
-0.004434114,
0.008926401,
0.0033045781,
-0.013496253,
0.028879913,
-0.007730612,
0.014155553,
0.0029862397,
0.004472896,
0.012319855,
-0.013483325,
0.013341123,
0.023489168,
-0.0097796125,
-0.003984885,
-0.01953337,
-0.025195591,
-0.014659723,
0.006037117,
-0.01619809,
0.033999182,
-0.02302378,
-0.008318811,
0.029991673,
-0.002981392,
0.011402006,
-0.0064992732,
-0.008829445,
-0.0050352397,
-0.0029312982,
-0.011414934,
-0.02064513,
-0.010425985,
-0.013185994,
-0.0113890795,
-0.018899925,
0.007937452,
0.0058884514,
-0.014323609,
0.013237704,
-0.021718107,
0.011214559,
0.013483325,
-0.0086807795,
-0.0013097118,
-0.0026695174,
-0.0054553817,
-0.02717349,
-0.022739377,
-0.018188916,
-0.024975823,
0.0031753038,
-0.007782322,
0.0017048068,
0.013366979,
-0.0058108866,
-0.012630114,
0.032473743,
-0.0043953313,
0.021381995,
-0.026785666,
0.03986824,
0.024057975,
-0.0055297147,
-0.032706436,
-0.0011683179,
0.0071682683,
-0.0024982288,
0.0112598045,
0.02408383,
-0.019843629,
-0.0046991264,
0.038497932,
0.016133452,
-0.008506259,
-0.010897837,
0.020063395,
-0.009314224,
-0.017477905,
-0.009495209,
-0.018408682,
-0.010742707,
0.015422442,
-0.009792539,
0.022984998,
0.0013864685,
-0.012306928,
-0.007181196,
-0.0006875785,
-0.02323062,
0.019352386,
0.0011061046,
-0.027380329,
-0.013780656,
-0.022713521,
-0.009087994,
-0.0020166815,
-0.006153464,
0.020632202,
0.0040883045,
-0.0028359583,
0.002052232,
-0.007730612,
-0.00814429,
-0.0013654614,
0.00022946215,
0.042634714,
-0.006799836,
0.0066511706,
-0.016585913,
0.005170978,
0.023747716,
0.013974568,
0.00054376066,
-0.0069743567,
-0.024213105,
0.0011489267,
0.020050468,
0.0306639,
-0.010736243,
0.0105100125,
-0.008706634,
-0.005426295,
-0.020903679,
-0.025273155,
-0.0063247527,
-0.049951646,
-0.0066382433,
-0.014931199,
0.026191004,
0.020334871,
-0.0050740223,
0.0034613234,
-0.018537957,
0.036196847,
-0.0019423487,
-0.0052388473,
0.022519609,
0.021472486,
-0.029371155,
-0.023140127,
-0.0077887857,
-0.011434325,
-0.0036875538,
-0.0026759813,
-0.018059641,
-0.032861564,
-0.009818395,
0.028517945,
0.020890752,
-0.027768152,
0.029784834,
-0.0124491295,
0.016469564,
-0.0062568835,
-0.011822148,
0.026785666,
0.0016070431,
-0.010865518,
-0.00019875947,
-0.017361559,
0.0045052147,
0.009572773,
0.0049512116,
-0.017464979,
-0.042531297,
-0.03653296,
-0.016211016,
0.012436203,
0.01189325,
0.008325275,
-0.004098,
-0.0035033377,
-0.014026278,
-0.00034904102,
-0.0039945804,
-0.0064475634,
-0.012403884,
0.013147212,
-0.0033902226,
0.015150966,
0.0095146,
-0.002491765,
-0.008280029,
-0.038161818,
-0.010645751,
0.008312347,
-0.014284827,
0.013909931,
-0.0009776381,
0.012933909,
-0.019727282,
-0.019817773,
-0.047392014,
-0.0004823553,
0.025182663,
0.010697461,
0.0129533,
0.017671818,
-0.0011545825,
0.0044405772,
-0.005032008,
0.017387414,
0.015422442,
-0.022623029,
0.014530448,
0.013974568,
0.016482493,
0.020890752,
-0.015603427,
-0.0016296661,
0.0043694763,
0.00085805915,
0.0009364318,
0.027095925,
-0.03991995,
-0.00027592015,
-0.0037263362,
0.016120525,
-0.0038103645,
0.021562979,
-0.012933909,
-0.0051321955,
-0.018188916,
0.016042959,
0.010723316,
-0.017322777,
-0.020102177,
0.007698294,
0.011033574,
0.02054171,
-0.00423697,
-0.03293913,
0.010865518,
-0.004731445,
0.025829036,
-0.0038943929,
0.017077155,
0.012513767,
-0.011065893,
-0.005991871,
0.013302341,
-0.0052711656,
-0.03456799,
0.0052129924,
0.018899925,
0.013418688,
0.0020845504,
0.0010640903,
0.000606782,
-0.02151127,
-0.021007098,
-0.01684446,
-0.020050468,
-0.04746958,
0.034878246,
0.005649294,
-0.027819863,
-0.015448297,
0.0035453518,
-0.025854891,
-0.025622196,
-0.004333926,
0.01178983,
-0.009585701,
-0.005248543,
-0.008202464,
0.008654924,
-0.009042748,
0.022235205,
0.014452884,
-0.027406184,
-0.014052133,
0.18884411,
-0.034542132,
-0.004783155,
0.0149570545,
-0.025441213,
-0.0058432054,
0.014181407,
0.00857736,
0.010283783,
0.0035550473,
0.00573009,
0.014969981,
-0.010451839,
0.013573818,
-0.0030266382,
-0.00390732,
-0.03953213,
-0.029733123,
-0.009217269,
-0.024200177,
0.0023463313,
-0.0009396637,
0.009353006,
-0.0112598045,
0.026889086,
-0.008241246,
-0.019778991,
0.022118859,
0.017723527,
-0.02049,
-0.020709768,
-0.007885742,
-0.00447936,
0.00012089181,
-0.009488745,
-0.0011473107,
-0.0064410996,
-0.029009188,
0.0062633473,
0.024768986,
0.010619896,
-0.002307549,
-0.023502095,
-0.005051399,
-0.004847792,
0.014375319,
-0.0028343424,
-0.03906674,
0.020606348,
-0.004912429,
-0.032292757,
-0.008738953,
0.009889496,
0.015926613,
0.015849048,
-0.00111984,
0.022623029,
-0.0023430993,
-0.01085259,
0.028802348,
-0.004754068,
0.027199345,
-0.025363648,
0.026552973,
-0.012190581,
0.031439546,
-0.0071100947,
0.017555472,
0.026216859,
-0.028517945,
-0.003865306,
-0.03495581,
-0.033120114,
0.007885742,
0.011660555,
-0.01001877,
0.043229375,
0.010859054,
0.014155553,
0.005668685,
-0.000024832309,
0.0092108045,
-0.048658904,
-0.002701836,
-0.00908153,
-0.043539636,
0.028957477,
0.02266181,
-0.0054618455,
-0.0040172036,
0.0129533,
0.011641164,
0.009204341,
0.007808177,
0.035705604,
0.023941629,
0.010975401,
0.0041367826,
-0.005145123,
-0.0032593322,
-0.016831534,
0.06251712,
0.019417023,
-0.0059498567,
-0.024665566,
0.0043177665,
-0.0038297556,
-0.0037651183,
0.023864064,
-0.016456638,
-0.000005403268,
-0.009113849,
0.009062139,
-0.00661562,
-0.0034354685,
0.015642209,
0.014090915,
-0.00619871,
0.0022913897,
-0.001421211,
-0.0071165585,
-0.01583612,
0.02707007,
0.02085197,
-0.020774404,
-0.003774814,
-0.019778991,
0.012856345,
-0.009714975,
-0.023411604,
0.0074914545,
-0.007976234,
-0.035550475,
0.0045278375,
0.01892578,
0.013522108,
0.0078211045,
-0.016379073,
-0.017180575,
-0.013205385,
-0.0070519214,
-0.014646796,
0.02029609,
0.002330172,
0.0044179545,
-0.02484655,
0.037282754,
0.0005175018,
-0.023812354,
-0.008829445,
-0.025531704,
-0.02675981,
-0.018253552,
-0.02439409,
0.023269402,
-0.038937464,
-0.0069549656,
-0.025790254,
0.018951634,
0.005038472,
-0.014271899,
0.028854057,
0.030379497,
-0.03785156,
0.01543537,
0.0021023257,
-0.16061059,
0.0071165585,
-0.0038943929,
0.004702358,
0.043487925,
0.018550884,
-0.001609467,
0.0024562145,
-0.018188916,
0.03363721,
0.021394921,
0.01725814,
-0.05486408,
-0.022532538,
-0.004285448,
-0.02074855,
-0.012151798,
0.025195591,
0.041729793,
0.000909769,
0.026165148,
-0.038575497,
0.01562928,
-0.007594874,
-0.0032528683,
0.021588834,
0.014801925,
-0.007316934,
-0.026656393,
-0.018279407,
-0.005649294,
0.011020647,
0.018731868,
-0.008512722,
0.01826648,
0.0007146453,
0.011763975,
-0.012765852,
0.008338202,
-0.0010083407,
0.048452064,
0.0237865,
0.00055870804,
0.009230196,
-0.0020667752,
0.043979168,
0.0061922465,
-0.016133452,
0.006062972,
0.001164278,
0.027251054,
-0.0123586375,
0.029836543,
0.014608013,
0.005545874,
-0.0077887857,
0.010910763,
0.0016434015,
0.0040656817,
0.00016694583,
-0.027380329,
-0.014233117,
0.0033223534,
-0.010102798,
-0.0012749693,
-0.04483238,
-0.0070713125,
0.013205385,
-0.025751472,
-0.009630946,
-0.01583612,
-0.00946289,
0.025932455,
-0.025195591,
0.008493331,
0.016741041,
-0.029112607,
0.01675397,
-0.011324442,
-0.0025741775,
-0.018757723,
0.020166814,
-0.008984574,
-0.004359781,
-0.015616354,
-0.0033643676,
-0.018706013,
0.0090104295,
-0.000083119434,
-0.03953213,
-0.0056719165,
-0.019261893,
-0.013037329,
-0.0058755237,
0.00019593159,
0.02580318,
-0.00017553047,
0.0014801925,
-0.011770439,
0.0029280663,
0.027897427,
-0.0070260665,
-0.024226032,
0.026527118,
0.040411193,
-0.011570063,
0.0011553904,
0.00928837,
0.05486408,
-0.011020647,
-0.016585913,
0.010057553,
0.0115636,
0.007737076,
-0.013444543,
0.0005425487,
-0.008667852,
0.0069355746,
0.019003345,
-0.030069238,
0.057139307,
0.005287325,
-0.02418725,
0.009178486,
-0.015396588,
0.00026885048,
-0.13020523,
-0.015719773,
-0.016572984,
-0.002868277,
-0.0031413692,
0.007407426,
-0.0074526723,
0.016870316,
-0.004405027,
0.03345623,
-0.018964563,
-0.01366431,
-0.014310682,
-0.031620532,
0.032732293,
0.016456638,
0.008965183,
0.003797437,
-0.03997166,
0.024626784,
-0.00008135201,
-0.0032722596,
-0.012895127,
-0.020102177,
0.022558391,
-0.0038362194,
-0.029371155,
0.016030032,
0.021782745,
0.024536291,
0.00769183,
-0.015021691,
0.005985407,
-0.009831322,
0.017064227,
0.013819439,
-0.032525454,
-0.022713521,
0.01562928,
-0.027147636,
-0.0047249813,
0.012765852,
0.003496874,
-0.008370521,
0.00004312515,
-0.019003345,
-0.019248966,
0.005361658,
0.024096757,
0.0046409527,
0.0005538602,
-0.021950802,
-0.031206854,
-0.012390956,
-0.008913473,
-0.024588,
-0.0050675585,
0.032525454,
-0.00026299272,
-0.0017613644,
0.020683913,
-0.008868228,
0.004333926,
0.0008499795,
0.038575497,
0.0006693993,
0.009766685,
-0.0035227288,
0.029758979,
-0.015965395,
-0.005500628,
-0.016741041,
-0.0043727085,
0.007685366,
-0.009908887,
0.0070389938,
-0.017801093,
-0.020580493,
0.0024756058,
-0.014582158,
-0.0066317795,
-0.003078348,
0.022222279,
0.017671818,
0.05889744,
0.0074203536,
-0.015099256,
0.011253341,
0.016211016,
-0.0025984165,
0.009294833,
0.02833696,
0.0013307189,
-0.03436115,
0.014052133,
0.01100772,
-0.0021798904,
-0.028621364,
0.037773997,
0.02307549,
0.0017177343,
-0.010535868,
-0.058018375,
0.029293591,
-0.0029216027,
0.0037812777,
0.021213938,
0.021058809,
0.007174732,
-0.014853635,
-0.0005425487,
0.043074246,
-0.0027535458,
0.02944872,
-0.010846127,
0.0043920996,
-0.025273155,
-0.013127821,
0.017167646,
-0.0043727085,
0.010975401,
0.028647218,
-0.0004262017,
0.015680991,
0.002262303,
0.02130443,
0.0041755647,
-0.022687666,
0.0056202067,
0.032784,
-0.029267736,
-0.014013351,
0.0058852197,
-0.030095093,
0.0058302777,
0.0071424134,
-0.006431404,
-0.019856555,
0.008706634,
0.020774404,
0.027509604,
0.07058385,
-0.013935786,
-0.03839451,
0.008693707,
-0.0038103645,
-0.018227698,
0.0016474413,
-0.028569654,
0.02611344,
0.014478738,
-0.011873858,
0.020102177,
0.015861975,
-0.011162849,
-0.042789843,
0.008848837,
0.011279196,
-0.0028343424,
-0.00764012,
-0.014763142,
-0.002609728,
0.024238959,
0.025479995,
0.00013179934,
0.0019859788,
-0.012003133,
-0.022351554,
-0.029991673,
-0.0066640982,
0.008512722,
-0.021097591,
0.0073040067,
0.019468732,
-0.009126776,
0.01665055,
-0.01224229,
-0.003052493,
-0.0237865,
0.03156882,
-0.011363224,
0.017232284,
-0.0088553,
-0.013289413,
0.00087664236,
0.004964139,
0.04948626,
0.0051321955,
-0.00814429,
0.032266904,
-0.013089038,
0.0071165585,
-0.00053406507,
0.0070002116,
0.012882199,
0.024019193,
-0.013237704,
0.008706634,
-0.007995625,
0.014504594,
-0.00731047,
0.03436115,
-0.0064895777,
0.0054424545,
0.013806512,
-0.038135964,
-0.017620107,
0.0062633473,
-0.028259395,
-0.03299084,
-0.014556304,
0.007834032,
0.013121357,
-0.003865306,
-0.008389912,
0.006412013,
-0.01665055,
0.0034128455,
-0.008053798,
0.019778991,
0.002614576,
0.026281497,
0.02028316,
0.02297207,
0.0157327,
0.0056589893,
-0.022338625,
0.0039234795,
-0.0036875538,
-0.0064798817,
-0.00029914916,
-0.030095093,
-0.005219456,
-0.0040915366,
-0.026268568,
-0.0050740223,
-0.003493642,
-0.026022946,
0.022700593,
0.0073751076,
-0.0074785273,
0.05631195,
-0.007859887,
-0.0035194969,
0.009036284,
-0.041859068,
0.01665055,
0.034645554,
-0.017542543,
0.003564743,
-0.019908266,
0.022752304,
-0.0067158076,
0.00019684056,
-0.04129026,
-0.053881593,
0.019300675,
-0.0022493755,
0.0051160366,
-0.008124899,
-0.014026278,
0.015448297,
-0.009301296,
0.011957887,
0.015874904,
-0.014142625,
-0.0025434748,
0.014814852,
-0.0043403897,
-0.013095502,
-0.036713943,
0.000025147921,
-0.012087162,
-0.04191078,
-0.008008553,
0.024432871,
-0.028233541,
-0.020658057,
-0.02540243,
0.021239793,
0.019804846,
-0.013832366,
0.019171402,
-0.017529616,
-0.017516688,
-0.008163681,
-0.023618443,
-0.036351975,
-0.017477905,
0.0014349464
] |
Although humans have been exposed to airborne nanosized particles (NSPs; < 100 nm) throughout their evolutionary stages, such exposure has increased dramatically over the last century due to anthropogenic sources. The rapidly developing field of nanotechnology is likely to become yet another source through inhalation, ingestion, skin uptake, and injection of engineered nanomaterials. Information about safety and potential hazards is urgently needed. Results of older biokinetic studies with NSPs and newer epidemiologic and toxicologic studies with airborne ultrafine particles can be viewed as the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of | [
0.011968881,
0.0071056937,
0.01380004,
-0.0064986246,
-0.011325321,
0.007789061,
-0.021814678,
-0.01487485,
-0.016984664,
-0.011484552,
0.009487527,
-0.013680616,
-0.012725229,
-0.0007181992,
0.041638967,
0.0016951491,
0.036755875,
-0.0038082802,
0.014330811,
-0.00753031,
-0.029325085,
0.02324776,
-0.005957902,
-0.023314105,
-0.0057787667,
0.016785625,
0.027838927,
-0.041161273,
-0.024057185,
-0.0049627065,
-0.0030005134,
0.006140354,
-0.015471968,
-0.007895215,
0.010840992,
0.021283908,
0.00047354703,
-0.015617929,
0.0016827092,
-0.03428779,
0.011743303,
0.020355059,
-0.0008542092,
0.007437425,
0.007483868,
0.0034665966,
-0.013116673,
-0.0018013032,
-0.020063134,
-0.000894017,
0.030280473,
0.007908484,
-0.02123083,
-0.027162194,
-0.017661396,
-0.027520465,
-0.0041964063,
0.012725229,
0.021363523,
-0.024402186,
-0.00817387,
-0.00023615152,
-0.03014778,
0.014622735,
-0.01669274,
0.024840072,
0.002142987,
0.018391207,
-0.049282067,
-0.014304272,
0.032536246,
0.0163212,
0.014861581,
0.010502626,
0.0054868427,
0.00034728166,
-0.005719055,
0.01397254,
0.0016404134,
0.008956756,
0.019930443,
-0.003022076,
0.0000897749,
0.026405845,
0.010031567,
0.010635319,
-0.008147331,
0.011975516,
0.015180044,
-0.022159679,
0.024587955,
0.0048897257,
0.00060250773,
0.007583387,
-0.017502166,
0.03067855,
-0.0033853222,
0.027547002,
0.0020102942,
-0.023659106,
-0.02629969,
0.0016130455,
-0.0061834794,
-0.007928388,
-0.02108487,
0.004276022,
0.016268123,
-0.0015176727,
0.0050423224,
-0.010641954,
-0.0017498848,
0.012891095,
0.011670322,
-0.009301757,
0.003964194,
0.0068668467,
0.009407911,
0.0015102087,
0.0060905945,
-0.03373048,
0.042727046,
0.021164484,
0.017727744,
-0.019757941,
0.025702573,
0.027892003,
-0.023871414,
-0.004601119,
0.0023138288,
-0.013906194,
-0.0037253473,
0.005175015,
0.028582005,
0.008313197,
-0.009971855,
0.0016802212,
-0.01997025,
-0.01506062,
-0.03213817,
-0.028183928,
0.024601225,
0.024256224,
-0.022371987,
0.004966024,
0.02359276,
0.03526972,
0.019718133,
0.028555468,
0.008140696,
-0.008996564,
0.012804844,
-0.0012348713,
0.01943948,
0.004023906,
-0.016135432,
0.023075258,
-0.008326466,
0.0056692953,
-0.017701205,
0.009938682,
0.009003199,
-0.012360324,
0.009540604,
0.015286198,
-0.0036225105,
0.014184848,
0.0056394394,
-0.0016843679,
0.011630515,
-0.0010681761,
-0.02030198,
0.022836411,
-0.0035495295,
0.0035893372,
0.0040902523,
0.010986955,
-0.0009097743,
0.011849457,
-0.002964023,
-0.01398581,
0.016745817,
-0.0059778057,
0.033305865,
0.009308392,
-0.016161969,
-0.020660251,
0.036198568,
0.022637373,
-0.0055166986,
-0.0294047,
-0.0046475613,
0.0012721912,
-0.016042545,
-0.04246166,
-0.64796495,
-0.041877814,
0.004319147,
-0.016639663,
0.0035296255,
0.023154875,
0.023884684,
0.004853235,
0.010316856,
0.03213817,
-0.011842823,
0.013096768,
0.023499876,
-0.008299928,
-0.005098717,
-0.007583387,
-0.0052479957,
-0.015763892,
0.035296254,
0.00083513465,
-0.033279326,
0.0043224646,
-0.006846943,
0.015365814,
0.003745251,
-0.00012128941,
0.025384111,
-0.008950122,
-0.016082354,
0.014556388,
0.0014305931,
0.017940052,
0.0049859276,
0.017820628,
0.053952847,
-0.01723678,
0.0026322913,
0.020063134,
0.018099284,
0.011146186,
-0.031288937,
0.013461674,
0.01995698,
-0.007749253,
-0.0019655104,
0.030758165,
0.014131771,
-0.019678326,
0.0118959,
-0.014503311,
0.025450459,
0.012539459,
-0.001370052,
0.023380453,
0.0037187126,
0.00011797209,
-0.003046956,
-0.0041134735,
0.022172948,
0.0011834529,
-0.008061081,
0.0027036136,
-0.019213902,
-0.03526972,
-0.015193313,
0.027082577,
-0.033279326,
0.015339275,
0.0073180017,
-0.03014778,
0.027440848,
0.044160128,
0.0032642402,
-0.012214362,
0.0028246955,
0.005314342,
0.0016147041,
-0.0042528007,
-0.024004107,
0.012964075,
0.0009976831,
-0.0025062333,
-0.04737129,
0.002594142,
0.0077227145,
-0.012313882,
-0.0051086685,
0.016374279,
0.01378677,
-0.012625709,
0.0059778057,
0.024826802,
-0.011968881,
-0.03375702,
-0.026750846,
0.0034665966,
0.025516804,
-0.013627539,
-0.018762747,
0.0010607122,
-0.01451658,
-0.01361427,
0.0118959,
-0.025888344,
0.038401265,
-0.011723399,
0.025131995,
0.0012066741,
0.023552952,
-0.014145041,
0.03049278,
-0.0057787667,
-0.021841217,
-0.011650418,
-0.0007596657,
-0.027440848,
0.010582242,
-0.004591167,
-0.011617245,
-0.044027433,
0.00690002,
-0.0050456394,
0.005513381,
-0.017701205,
0.002230896,
0.015126967,
0.013488212,
-0.006040835,
-0.01762159,
-0.03468587,
0.0008575265,
-0.01726332,
-0.0013377082,
-0.012652248,
0.013010519,
0.013826578,
0.013932733,
0.010555703,
0.0020998619,
-0.028343158,
-0.030439703,
-0.019134287,
-0.016586587,
0.0025128678,
-0.009036372,
-0.021191023,
0.0017133944,
0.011139551,
-0.011351859,
0.0075104064,
0.013368788,
-0.013229461,
-0.0025642863,
0.04413359,
0.022239296,
0.005188284,
0.0047205426,
-0.040948965,
0.005052274,
0.015020813,
0.01361427,
0.020355059,
-0.018192168,
-0.018762747,
0.0064455476,
-0.02016929,
0.005563141,
0.016055815,
0.040232424,
-0.05589016,
0.023300836,
-0.03646395,
-0.022425065,
0.0297497,
-0.0047105905,
0.01760832,
0.004654196,
0.009998394,
0.0035793853,
0.00088074774,
-0.021376792,
-0.044770513,
0.0028645035,
0.027892003,
0.01760832,
0.0039476077,
0.015710814,
-0.01225417,
-0.01415831,
0.04593821,
-0.008784256,
0.013401962,
-0.016984664,
0.0033869809,
0.011657053,
-0.0348451,
-0.009507432,
-0.001289607,
0.015564852,
0.019320056,
0.022756796,
-0.009480893,
0.018377937,
-0.023314105,
0.032350477,
-0.022398526,
-0.02034179,
0.00072358985,
0.0077094454,
0.013826578,
0.0016312908,
0.019505825,
-0.03181971,
-0.014211387,
0.0021711842,
0.0061536236,
-0.007696176,
-0.015471968,
0.0035428947,
-0.015485237,
0.012121477,
-0.010170895,
0.021628909,
-0.020554097,
-0.015896585,
0.027202,
-0.005805305,
0.017661396,
-0.01016426,
-0.013919463,
-0.009885605,
-0.014649273,
0.0050423224,
-0.010973685,
0.016440624,
0.010469453,
0.0014538143,
-0.021257369,
0.025131995,
0.028927006,
0.0019223853,
-0.0009097743,
0.00962022,
0.009069545,
0.04121435,
0.010648589,
0.027812388,
0.006292951,
0.0027898639,
-0.01942621,
0.0035163562,
-0.01125234,
-0.021124676,
0.0003327684,
0.0013435135,
-0.016175238,
0.010124452,
0.00082891464,
0.024256224,
-0.0010988613,
0.009109354,
-0.018285053,
0.024349108,
-0.035694335,
0.019850826,
-0.021920832,
-0.008558678,
-0.0049958797,
-0.021907562,
0.02669777,
-0.020753136,
-0.009182334,
0.01851063,
-0.004883091,
0.030731628,
0.016453894,
0.0056095836,
0.0037983283,
0.03120932,
0.009089449,
-0.04561975,
-0.016931588,
-0.009122622,
0.029431239,
-0.0031912592,
-0.017714474,
-0.03444702,
0.010847627,
-0.016785625,
-0.009295123,
0.015644468,
0.016042545,
-0.00906291,
0.018231975,
-0.013959271,
-0.013163115,
0.0075104064,
-0.010986955,
0.0020998619,
0.012632344,
0.0036988088,
-0.012539459,
0.004776937,
-0.00535415,
0.0053475155,
0.0073047327,
0.0011668664,
-0.013932733,
-0.016533509,
-0.024932956,
0.0047835717,
-0.02466757,
-0.0023287567,
0.016997933,
-0.010913974,
0.0009885605,
-0.030837782,
-0.0022773384,
0.024707379,
-0.032191247,
0.0066114133,
-0.03792357,
0.001659488,
0.026180267,
0.05177669,
-0.0017432502,
-0.01297071,
0.01905467,
-0.00853214,
-0.013534655,
-0.01269869,
-0.0072649247,
0.02068679,
-0.002886066,
-0.00058633584,
-0.0010723228,
0.01906794,
0.001460449,
0.017276589,
0.013720424,
-0.013521385,
-0.015538314,
-0.028927006,
-0.020819483,
0.010555703,
-0.009666663,
0.033810098,
0.04232897,
-0.0039277035,
0.006913289,
-0.0052115056,
0.021827947,
-0.00613372,
0.0043655895,
0.030041626,
0.015671007,
0.002288949,
0.024043916,
-0.024388917,
-0.0023055356,
-0.004956072,
0.008100889,
0.003037004,
-0.004800158,
-0.013083499,
0.011285514,
0.005559824,
-0.0037187126,
0.008372908,
-0.0023304154,
0.009699835,
0.0071189627,
-0.022252563,
0.0023304154,
0.034818564,
0.0029607057,
-0.017130626,
-0.029298546,
-0.007298098,
-0.0032476536,
0.020355059,
-0.022557758,
-0.024070455,
-0.013959271,
-0.019757941,
-0.022425065,
0.014145041,
-0.006253143,
-0.033226248,
-0.032350477,
-0.010177529,
0.0014339103,
-0.008120793,
0.0026621472,
0.024388917,
-0.032323938,
-0.0069199237,
-0.008286659,
0.031687014,
-0.0070658857,
0.005695834,
-0.006087277,
-0.023194682,
0.033465095,
-0.010323491,
-0.008333101,
-0.012658883,
-0.017674666,
0.03067855,
0.0027683012,
0.0035727506,
-0.015087158,
-0.027679695,
-0.018630054,
0.010131087,
-0.012274073,
0.004110156,
0.02234545,
-0.010097913,
0.008498967,
0.00644223,
0.05299746,
-0.007881946,
-0.014410426,
-0.012453209,
0.0032526297,
-0.010442914,
-0.024959495,
0.023340644,
-0.002939143,
-0.007536945,
0.018603515,
-0.007643099,
0.0011403278,
0.00826012,
-0.025291227,
0.021708524,
0.0026057528,
0.0056095836,
0.020633712,
0.013461674,
0.018935246,
-0.01507389,
0.018470822,
-0.017276589,
0.00039787072,
0.02722854,
0.01634774,
-0.007676272,
0.012426671,
0.015034081,
0.0019140921,
-0.038029727,
0.00035225763,
-0.011816284,
0.015286198,
0.023353914,
-0.021642178,
-0.00944772,
-0.02161564,
-0.015591391,
-0.001243994,
-0.0016412428,
-0.029298546,
-0.0076696374,
-0.0007231752,
-0.0077956957,
0.01378677,
0.026936617,
-0.030625474,
0.0078089647,
0.028024696,
-0.015365814,
0.012632344,
-0.029908933,
-0.019121017,
-0.01225417,
-0.021668715,
-0.023367183,
-0.015525045,
-0.01997025,
-0.015830237,
0.052307457,
0.02142987,
0.041320503,
-0.0075568487,
-0.009043007,
0.016228316,
-0.007298098,
0.017435819,
-0.010343395,
-0.0059977095,
-0.011245705,
0.02324776,
0.017953321,
-0.0011270585,
-0.008790891,
-0.03359779,
-0.013289173,
0.00208991,
-0.010111183,
-0.013275904,
-0.008140696,
-0.037127417,
-0.0034466926,
-0.0062796813,
-0.012751767,
0.040789735,
-0.022650642,
0.005005832,
0.010363299,
-0.0016661226,
0.0021678668,
-0.01397254,
0.025105458,
-0.0017963273,
-0.00088074774,
-0.024375647,
0.02123083,
-0.026578346,
-0.013202922,
-0.009009833,
-0.01451658,
0.003323952,
-0.0026953202,
-0.004372224,
0.010655223,
0.0029159219,
-0.005543237,
0.010343395,
0.021801408,
-0.00071985787,
-0.01289773,
-0.0075170407,
-0.010250511,
0.0032493123,
-0.011013493,
-0.044929747,
0.010867531,
-0.007769157,
-0.0042295796,
0.02722854,
-0.027334694,
0.00516838,
0.012791575,
-0.0048499177,
-0.01142484,
-0.01524639,
0.043602817,
0.019864095,
-0.014397157,
-0.038613573,
-0.0077757915,
0.0017266637,
-0.011544264,
0.01686524,
0.000016716169,
-0.020739868,
-0.015870046,
0.03174009,
0.011000224,
-0.020474482,
-0.05594324,
0.028661622,
0.0013542947,
0.002924215,
-0.01851063,
-0.03556164,
-0.0053939577,
0.028741237,
0.008644929,
-0.024428723,
0.00690002,
-0.008353005,
-0.0053906403,
0.0029872442,
0.0075037717,
0.022809874,
0.02014275,
0.014131771,
-0.0070526167,
-0.01763486,
0.0077426187,
0.00087908906,
-0.020248905,
0.012154651,
0.010204067,
-0.015180044,
0.010369934,
0.0031531102,
0.015471968,
0.008094254,
-0.0060607386,
0.044531666,
-0.0071985787,
-0.017701205,
-0.008950122,
-0.00055896793,
0.008611755,
-0.013508116,
-0.0035263083,
-0.018948516,
-0.0021778187,
-0.0074705984,
0.023168143,
0.023951031,
-0.005039005,
-0.017024472,
-0.011365129,
-0.013813309,
-0.008711275,
-0.024561416,
0.009102719,
-0.03540241,
-0.018590245,
0.004806793,
-0.010542435,
0.006044152,
0.0077757915,
0.0016138748,
-0.017090818,
0.019187363,
-0.02326103,
0.012546094,
0.010131087,
0.027679695,
-0.009600316,
0.005261265,
-0.009003199,
-0.01816563,
0.0026024354,
0.009407911,
-0.0402855,
-0.007981465,
-0.02669777,
0.010774647,
0.03524318,
-0.0065417495,
0.049812835,
-0.01043628,
0.002142987,
-0.01981102,
-0.0040803,
0.011849457,
-0.009129257,
0.010097913,
0.020288711,
-0.018603515,
-0.005825209,
-0.025676036,
-0.00521814,
-0.002560969,
-0.0134285,
-0.01180965,
-0.0039675115,
-0.011690226,
-0.0043025604,
-0.019134287,
-0.0035362602,
0.01316975,
-0.02194737,
0.0073047327,
-0.007835504,
-0.002692003,
-0.016307931,
0.0029955376,
0.006054104,
-0.0081606,
-0.012353689,
-0.0025161852,
0.011338591,
-0.014171579,
-0.023353914,
-0.00881743,
0.009255315,
0.046389364,
0.018749477,
-0.008100889,
-0.035614718,
-0.0063427105,
-0.047105905,
-0.008863872,
-0.004455157,
0.00990551,
0.0062465086,
0.023486607,
-0.0009918779,
-0.011113013,
-0.01079455,
0.0059744883,
-0.025277957,
-0.033969328,
0.010701666,
-0.008591852,
0.0263395,
0.020660251,
-0.04561975,
0.017674666,
0.050768223,
-0.0073644444,
-0.007351175,
0.019996788,
0.009029738,
0.007643099,
-0.04047127,
0.009832528,
0.0021512802,
0.0075634834,
-0.009945317,
-0.014410426,
-0.0007696176,
0.005918094,
-0.02669777,
-0.012632344,
-0.011856092,
0.012400132,
0.0041035214,
0.007497137,
-0.00018058646,
-0.023367183,
0.0020965445,
-0.019704865,
0.010462819,
0.018802553,
-0.0006841967,
0.024349108,
-0.020355059,
-0.004508234,
-0.016148701,
-0.013309076,
-0.017210241,
0.00093797146,
0.012035227,
-0.01598947,
0.012599171,
0.009003199,
-0.0001642072,
-0.023287566,
0.020660251,
0.0060209306,
-0.0028844073,
-0.013773501,
0.011637149,
0.017820628,
-0.008498967,
-0.0067275194,
-0.007603291,
-0.013567828,
0.0075568487,
-0.010190799,
-0.0012763378,
-0.04559321,
0.032191247,
0.0057356413,
-0.020408135,
-0.00417982,
0.003430106,
-0.0022955835,
-0.0021197656,
0.0053408807,
0.16814817,
-0.010489357,
0.0037253473,
0.031501245,
-0.006787231,
-0.005068861,
0.011345225,
-0.008027907,
-0.01706428,
0.01125234,
0.04047127,
0.0057356413,
-0.019917173,
0.00045198447,
0.017024472,
0.010874166,
-0.03534933,
-0.014742158,
-0.006485355,
0.009401277,
-0.012778306,
-0.024932956,
-0.012114842,
-0.0025725795,
0.027334694,
-0.0026621472,
-0.033995867,
-0.018709669,
0.0046674656,
-0.0011137893,
0.0047271773,
-0.012519555,
0.007045982,
0.0047636675,
0.022093333,
0.007404252,
0.03537587,
-0.021018522,
-0.0013990785,
0.016254855,
0.019306786,
0.029086238,
-0.020952176,
-0.020938907,
0.011099744,
0.024481801,
-0.0013882973,
-0.01763486,
-0.024057185,
0.013255999,
-0.03269548,
0.007437425,
0.004047127,
0.0006054104,
-0.007815599,
0.014184848,
0.00333888,
0.008193773,
0.0053276117,
0.00989224,
-0.01851063,
0.009872336,
-0.019346595,
0.025211612,
0.0014670836,
0.03280163,
0.02250468,
0.02142987,
0.0017797407,
-0.007245021,
-0.014344079,
0.009388008,
-0.027255079,
0.021005252,
0.003934338,
-0.009653393,
0.013183019,
0.015724083,
0.01760832,
0.00060706906,
-0.005941315,
0.012877826,
-0.036039334,
0.013919463,
-0.011146186,
-0.030466242,
0.03208509,
-0.014052156,
-0.019333325,
-0.0017399329,
0.009726374,
0.029351624,
-0.012174554,
-0.004319147,
0.006309537,
0.0022723624,
0.017104087,
-0.00944772,
-0.0055797277,
0.021482946,
-0.029962009,
0.0729279,
0.017289858,
0.018921977,
-0.005301073,
0.01760832,
-0.024853341,
0.03189932,
0.013826578,
0.0016429013,
0.001967169,
-0.009985125,
0.02831662,
-0.01849736,
0.014848312,
0.020978713,
0.0041565984,
-0.019890634,
0.0351901,
-0.014370618,
0.0017366156,
-0.013839847,
0.016798895,
0.02032852,
-0.0058517475,
0.007225117,
-0.004614388,
0.0076298295,
-0.0074639637,
-0.020607175,
0.005510064,
-0.013879656,
-0.010091279,
-0.008207043,
-0.0014347397,
-0.024601225,
-0.0050788126,
-0.0013451722,
0.022093333,
0.0051385243,
-0.0025128678,
-0.019850826,
0.02813085,
0.018935246,
-0.017011203,
-0.0052778516,
0.032403555,
0.0076165604,
0.022305641,
0.0070526167,
-0.0064256433,
-0.034022406,
0.0046674656,
-0.017886974,
0.018112551,
-0.0048665046,
-0.016905049,
-0.014357349,
-0.012048496,
0.01812582,
-0.037605107,
0.011053301,
0.014835043,
-0.014012348,
-0.02123083,
-0.002740104,
-0.16708663,
0.017727744,
0.020209096,
-0.006156941,
0.035508566,
-0.0012000395,
0.009560509,
0.0045215036,
0.01979775,
-0.034977794,
0.043682434,
-0.0063957875,
-0.014105233,
-0.04588513,
0.036065873,
-0.013236096,
-0.0107083,
0.029484317,
0.045964748,
-0.002929191,
0.004869822,
-0.007583387,
0.021801408,
-0.0118959,
-0.0031414994,
0.04150627,
-0.017515436,
0.008585217,
-0.013050326,
-0.011875995,
0.0055929967,
-0.031501245,
0.02432257,
0.012479748,
0.021854486,
-0.007895215,
0.0011892582,
-0.01979775,
-0.006754058,
0.019386401,
0.026750846,
0.040126268,
0.008386178,
-0.017170435,
-0.022531219,
-0.018271783,
0.002031857,
-0.008127428,
0.026193537,
-0.006239874,
0.030625474,
-0.01634774,
-0.020726599,
0.018205438,
-0.0013534655,
-0.0043556374,
0.0010739815,
-0.010210702,
0.040073194,
-0.005596314,
-0.0059446325,
-0.012937537,
0.0022043574,
-0.013328981,
-0.0030718357,
-0.03362433,
0.0012647272,
0.013813309,
-0.023897953,
0.015896585,
-0.021748332,
0.005742276,
0.011650418,
-0.007815599,
0.025490265,
-0.0030287106,
-0.0004706444,
-0.0060706907,
-0.008837333,
0.008226947,
-0.013435135,
0.017555242,
0.0023486607,
0.014543119,
-0.005520016,
0.00971974,
-0.0060839597,
0.007881946,
-0.0068270387,
0.0045646285,
0.01596293,
-0.006389153,
0.005709103,
-0.00989224,
0.020991983,
0.013627539,
0.020116212,
-0.00861839,
0.007543579,
-0.0012473112,
-0.0020036597,
-0.0026787338,
-0.020952176,
0.03781742,
0.020554097,
-0.016918318,
0.015737353,
0.0012257487,
0.039277036,
-0.02160237,
-0.015272928,
0.001302047,
0.008717909,
0.028422775,
-0.009733009,
0.042886276,
0.00004667569,
-0.0015558217,
0.0037817417,
-0.051803228,
0.0518563,
-0.00023366354,
-0.02288949,
0.031182783,
-0.0014538143,
-0.028263543,
-0.12207727,
-0.024481801,
0.014861581,
0.025463726,
-0.010768012,
-0.00033504903,
0.0015632857,
-0.0011386692,
-0.001710077,
0.023008913,
0.017488897,
-0.01994371,
-0.002997196,
-0.00494612,
0.0037717896,
-0.012181189,
0.017581781,
-0.032934327,
-0.018669862,
0.023473337,
0.004591167,
-0.016560048,
-0.021403331,
0.002876114,
-0.017104087,
0.022902759,
-0.019266978,
0.023141606,
-0.0018925295,
0.010602146,
0.009301757,
-0.007895215,
-0.0064123743,
-0.03630472,
-0.031156244,
-0.0012464819,
-0.01812582,
-0.030094702,
0.018789286,
-0.01099359,
0.008319831,
0.02198718,
0.025543343,
0.016573317,
0.003430106,
-0.016467163,
-0.036968183,
0.014490042,
-0.009421181,
-0.02592815,
-0.020859292,
-0.014118502,
-0.018656593,
-0.015631199,
0.012672152,
-0.0034566445,
0.008711275,
0.018643323,
-0.018563708,
-0.023951031,
-0.001654512,
0.009766182,
-0.017077548,
0.0033869809,
-0.00725829,
-0.014383888,
-0.031315476,
-0.02884739,
0.00780233,
-0.02104506,
-0.0068005,
0.0021064964,
-0.007099059,
0.0026621472,
-0.024773724,
-0.016997933,
-0.0077227145,
-0.012831383,
-0.0028976765,
-0.013892924,
0.0021164485,
-0.023632567,
0.015843507,
-0.008147331,
0.006588192,
0.022796605,
0.02757354,
-0.007994735,
0.0046276576,
-0.008970026,
-0.0018825775,
0.016639663,
-0.0069066547,
-0.015697544,
0.007331271,
0.012658883,
-0.011816284,
-0.028343158,
0.00562617,
0.018338129,
0.0038016455,
-0.0215891,
-0.039064728,
0.007291463,
0.01633447,
0.012672152,
-0.02502584,
-0.013879656,
0.038374726,
-0.01398581,
-0.009341565,
0.024773724,
-0.019558903,
0.018457552,
-0.0056925165,
-0.000016780961,
-0.036596645,
-0.012360324,
0.02884739,
0.007855407,
0.009023103,
0.0017648127,
-0.005291121,
0.00067673274,
0.012493017,
0.016798895,
-0.0070725204,
0.02030198,
0.0057455935,
-0.00051998947,
0.0045347726,
0.0049428027,
0.023168143,
-0.01796659,
-0.0024315936,
-0.014304272,
-0.023274299,
-0.020885829,
0.017329665,
0.007371079,
0.0035329429,
0.038401265,
-0.012214362,
-0.041798197,
-0.014835043,
-0.01161061,
-0.008724544,
-0.008830698,
-0.009971855,
0.010316856,
0.017528705,
-0.012181189,
0.045088977,
0.019731402,
-0.02340699,
-0.02324776,
-0.033226248,
0.012546094,
0.01905467,
0.0050124666,
-0.000030633353,
-0.016745817,
0.037870493,
0.024468532,
0.005111986,
0.015219851,
0.0025394063,
-0.015511775,
-0.025875075,
0.0077757915,
0.0012572632,
-0.005801988,
-0.004899678,
0.020235635,
0.004368907,
-0.007238386,
-0.009242046,
-0.0033786877,
-0.025715843,
0.0031066677,
-0.019757941,
0.011942342,
0.007284829,
0.010768012,
-0.024242954,
-0.003702126,
0.02322122,
0.0061237677,
-0.03288125,
0.017196972,
-0.003795011,
0.012406766,
-0.029855855,
0.012366959,
0.0051716976,
-0.0036125586,
0.013063596,
0.009792721,
0.018802553,
0.011305417,
0.0031182782,
0.025105458,
0.014463503,
0.010681761,
0.008299928,
-0.023287566,
-0.025291227,
0.011935707,
-0.049839374,
-0.006754058,
0.009567143,
-0.008744448,
0.01815236,
0.008406082,
0.016281392,
-0.0036755875,
-0.04174512,
0.010091279,
-0.014808504,
-0.014941197,
-0.010409742,
0.023008913,
0.01796659,
0.012731863,
-0.0013294149,
-0.0051484765,
0.017024472,
-0.014848312,
0.018802553,
-0.013587732,
0.035773948,
-0.015936391,
0.0061204503,
-0.014184848,
-0.026113922,
-0.0014786941,
-0.009401277,
-0.028688159,
0.006531798,
0.0057323244,
-0.005344198,
0.04665475,
0.03174009,
0.008114158,
0.013090134,
-0.0057555456,
-0.00088904105,
0.02051429,
-0.0053607845,
-0.005281169,
-0.045407437,
-0.0054404004,
-0.014091964,
0.0059678536,
-0.0294047,
-0.02415007,
0.004607754,
-0.003090081,
0.015485237,
-0.013448404,
-0.002196064,
0.032217786,
-0.014078694,
0.022544488,
0.030015087,
-0.03213817,
0.0014231291,
0.040922426,
-0.010111183,
0.014131771,
-0.021098137,
0.005602949,
0.023088528,
-0.030943936,
-0.00924868,
-0.002730152,
0.003692174,
-0.013547923,
-0.015034081,
0.006326124,
0.0017233463,
-0.0016039229,
0.042222813,
-0.014012348,
0.0031663794,
-0.016175238,
0.0027915225,
-0.036410876,
0.00013580268,
0.00208991
] |
CONTEXT More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD). These agents can increase heart rate and blood pressure, raising concerns about their cardiovascular safety. OBJECTIVE To examine whether current use of medications prescribed primarily to treat ADHD is associated with increased risk of serious cardiovascular events in young and middle-aged adults. DESIGN, SETTING, AND PARTICIPANTS Retrospective, population-based cohort study using electronic health care records from 4 study sites (OptumInsight Epidemiology, Tennessee Medicaid, Kaiser Permanente California, and the HMO Research | [
-0.0059800055,
0.02171002,
0.015275014,
-0.051350046,
-0.015847014,
0.03510003,
-0.0028112526,
-0.016887015,
-0.017745016,
0.0071110064,
0.009789009,
0.013377012,
-0.0018671267,
0.007943007,
-0.005304005,
0.004576004,
0.046410043,
-0.02207402,
-0.020735018,
-0.008814008,
-0.019604018,
0.019162018,
0.0038122535,
0.0070330063,
-0.020449018,
-0.007774007,
0.020956019,
-0.02224302,
-0.010218009,
-0.011680511,
0.0040300037,
-0.013754012,
0.0009018758,
-0.030940028,
-0.0113035105,
0.010237509,
-0.018811017,
-0.010666509,
0.0029835026,
-0.01075101,
0.000019309588,
-0.007007006,
-0.008827008,
-0.0062725055,
0.002003627,
0.0063310056,
0.013006512,
-0.03408603,
-0.009724009,
0.02217802,
0.03437203,
0.018070016,
0.011862511,
0.014261013,
0.030732028,
-0.032032028,
-0.000078101635,
0.017927015,
-0.0025691274,
-0.046020042,
-0.0051935045,
-0.02122902,
-0.016744016,
0.019630017,
-0.032682028,
0.0014405638,
-0.0047027543,
0.02180102,
0.02382902,
-0.0062075057,
0.031200029,
0.030004026,
0.005544505,
-0.010322009,
0.009197508,
0.0029103777,
-0.019539017,
-0.021606019,
0.014651014,
0.01037401,
0.008177008,
-0.025207022,
-0.009217008,
0.03302003,
-0.00012014854,
0.013195012,
0.005226005,
0.0037310033,
-0.01136851,
-0.007754507,
-0.016094014,
-0.0012528761,
-0.009087008,
0.0148330135,
0.013884013,
0.028522026,
0.006896506,
0.049322043,
-0.016835015,
-0.01165451,
-0.012174511,
-0.0063212556,
-0.028574025,
-0.0016672515,
-0.009093508,
0.007787007,
-0.036998034,
-0.02267202,
0.0030712527,
-0.005255255,
-0.008014508,
0.031564027,
-0.0040105036,
-0.013936013,
-0.022932021,
0.008963508,
0.0036887533,
0.0018102516,
-0.0049855043,
-0.04612404,
0.012070511,
0.012876512,
0.029146027,
-0.001616064,
0.00034165656,
0.013481013,
-0.025857024,
-0.013637012,
0.027352024,
-0.0042217537,
-0.026130024,
-0.0037700033,
-0.008053508,
-0.0027170025,
-0.028886026,
0.018811017,
0.015938014,
-0.0049920045,
-0.04383604,
-0.03296803,
-0.0069680065,
0.019292017,
-0.020319019,
-0.0043615038,
-0.027768025,
0.037128035,
0.03551603,
0.030290028,
0.008502007,
0.00070768816,
0.0012480011,
-0.0040527536,
0.0024797523,
0.014950014,
-0.014456013,
0.027690025,
-0.03302003,
0.0027982525,
0.0015673139,
-0.0048782546,
0.014144013,
-0.015431014,
0.012863511,
-0.026884025,
0.008788008,
0.01183001,
-0.008398008,
-0.026806025,
0.0072605065,
-0.026364023,
-0.004657254,
0.037986033,
-0.029926026,
-0.01103701,
0.014521013,
-0.0056420052,
0.0017582516,
0.02277602,
-0.014183013,
-0.026507024,
-0.016458014,
-0.0016087515,
0.03198003,
0.026364023,
0.0076115066,
0.02282802,
0.015704013,
-0.004897754,
0.0017355016,
-0.04414804,
-0.013312012,
0.03385203,
-0.04789204,
-0.04334204,
-0.63814455,
-0.0018931268,
-0.024557022,
-0.019461017,
0.0017842517,
0.037258033,
0.021294018,
0.029588027,
-0.0072865067,
0.04469404,
0.0038285034,
0.026598023,
0.013520013,
-0.0069810064,
-0.0007316569,
-0.018915016,
-0.0005854068,
-0.019786017,
-0.0007109381,
-0.009535508,
0.0035945033,
0.02111202,
-0.006457756,
0.003341003,
0.03400803,
0.00048343794,
0.00035140658,
-0.011927511,
0.0064805057,
0.024479022,
0.019682018,
0.017810017,
0.018044015,
0.028704027,
0.051844046,
-0.017329015,
-0.006334256,
0.013234012,
-0.007455507,
0.012844011,
-0.011563511,
-0.014222013,
0.025207022,
-0.010458509,
-0.016965015,
0.0021011268,
0.013676012,
-0.0062075057,
0.010211509,
-0.0010530009,
0.0024505022,
-0.013884013,
-0.02281502,
-0.0047937543,
0.006695006,
0.020397019,
-0.007826007,
-0.013325012,
-0.017316015,
-0.0041730036,
-0.016445015,
0.024609022,
-0.0026373775,
0.017680015,
-0.0007897507,
0.024765022,
-0.033800032,
0.017316015,
0.000028031276,
-0.029900027,
-0.000553313,
0.013494012,
-0.0063927555,
0.01085501,
0.04724204,
-0.0018086266,
0.03517803,
0.005616005,
-0.034684032,
0.016510015,
0.0062692557,
0.018772017,
-0.02215202,
-0.013104012,
0.014781013,
-0.0118690105,
-0.0009465634,
0.017056016,
0.0025155023,
0.0013097512,
0.004446004,
0.009971009,
0.0061977557,
-0.051012047,
-0.004797004,
0.0018785017,
-0.016497014,
0.006805506,
0.03237003,
0.027326025,
-0.015327014,
0.0051382547,
-0.007774007,
0.013936013,
-0.015119013,
0.025636023,
-0.025545023,
0.005515255,
0.04378404,
-0.018785017,
0.0011180011,
0.0062107556,
-0.010023009,
-0.0012821262,
0.0038805036,
-0.029822027,
0.005684255,
-0.029848026,
0.004504504,
-0.019123018,
0.0060352553,
-0.004589004,
0.008066507,
-0.0006414693,
-0.000115476665,
-0.016458014,
-0.00031321903,
-0.004475254,
0.008079507,
-0.026065024,
0.009438008,
-0.019019017,
0.030030027,
0.0052910047,
0.016666016,
-0.0075010066,
0.016237015,
-0.017472016,
-0.004566254,
-0.0051122545,
-0.02354302,
0.0016883765,
0.010406509,
-0.0030468777,
-0.0134420125,
-0.01162851,
0.0015730014,
-0.0019581267,
-0.04589004,
-0.009613508,
-0.005424255,
-0.009230008,
-0.011602511,
0.020969018,
-0.0042120037,
-0.024349023,
0.0034547532,
-0.007741507,
-0.004728754,
-0.013325012,
0.01087451,
0.020540018,
-0.016159015,
-0.010601509,
-0.026585024,
-0.026832024,
-0.027742025,
0.012597011,
-0.013429012,
-0.03307203,
0.018941017,
-0.049140044,
-0.0021612518,
0.015951015,
0.002094627,
0.024310023,
-0.0026341274,
0.009379508,
-0.020644018,
0.006285506,
-0.0023513772,
-0.0012033136,
-0.019617017,
0.0036757533,
0.008612508,
-0.00016250015,
0.008950508,
0.0036920034,
-0.0023318771,
0.036296032,
0.004455754,
0.04222404,
-0.015899014,
0.012590512,
0.0029851277,
-0.023608021,
0.018083015,
-0.006396006,
-0.000791782,
0.02194402,
0.03333203,
-0.0027755024,
0.02146302,
-0.010725009,
0.02255502,
-0.0093080085,
0.002270127,
-0.018187016,
-0.0037895034,
-0.008404507,
-0.009756509,
0.003267878,
-0.000108062595,
-0.005284505,
-0.010322009,
0.024050022,
-0.02143702,
-0.0053332546,
0.0026845024,
0.016614014,
0.009314508,
-0.0112840105,
0.02200902,
-0.009626509,
0.0012309386,
0.004147004,
0.03455403,
0.015704013,
-0.013689012,
-0.004709254,
-0.0005443755,
-0.0026958773,
0.018551016,
0.011661011,
-0.019539017,
0.013767012,
-0.0093080085,
-0.026676023,
0.016978016,
0.017329015,
0.002408252,
0.008898508,
0.020319019,
-0.0043225037,
0.008534508,
0.020579018,
0.040092036,
0.019097017,
0.018382017,
0.013572012,
-0.0018362517,
-0.0046540042,
-0.0035782533,
-0.0036855033,
-0.0042217537,
0.0056712553,
0.012831012,
0.0073385066,
0.02259402,
0.031876028,
0.026494024,
0.0026471275,
0.004257504,
-0.014846013,
0.018603018,
0.01106951,
0.00005215239,
0.0151970135,
0.017082015,
-0.0049627544,
-0.017927015,
0.0016510015,
-0.015210014,
-0.050908044,
0.004491504,
0.013520013,
-0.011999011,
-0.0020670018,
0.012967512,
0.026676023,
0.012259011,
-0.023855021,
0.0018655016,
0.011823511,
-0.0140270125,
-0.01191451,
0.016809015,
0.008645007,
-0.013715012,
0.024193022,
-0.0072475066,
0.01097851,
-0.0073060067,
-0.0060840053,
-0.004615004,
-0.015106014,
0.029198026,
0.014768014,
0.01057551,
-0.005492505,
-0.006613756,
0.0030615027,
-0.02252902,
-0.008008007,
0.003173628,
0.007806507,
-0.0019516267,
-0.019266017,
0.004647504,
0.009574508,
0.040456038,
-0.00005174614,
-0.010140009,
0.010640509,
0.0071955062,
0.024440022,
-0.03182403,
0.016627016,
0.018941017,
0.009938509,
0.006295256,
-0.031200029,
-0.008469508,
-0.027378025,
0.06869206,
-0.02167102,
-0.014924013,
0.02185302,
-0.002289627,
-0.005538005,
0.011940511,
-0.0071045063,
0.02186602,
0.0035262532,
0.009340509,
-0.009314508,
0.003152503,
-0.01099151,
0.002226252,
0.02229502,
-0.00092218834,
-0.006818506,
-0.0049042543,
-0.005687505,
0.014573013,
0.020995019,
0.02174902,
0.026650025,
0.038012035,
-0.026130024,
0.0023562522,
0.039702035,
0.015938014,
-0.006594256,
-0.01119301,
-0.0023465022,
-0.011745511,
0.025519023,
-0.017628016,
-0.016237015,
-0.0005882505,
0.016458014,
0.007741507,
0.0059117554,
0.05376805,
-0.0027348774,
0.0056907553,
-0.008014508,
-0.0038317535,
-0.017628016,
0.014521013,
0.0042315037,
-0.0039942535,
-0.012096511,
0.004329004,
0.009945009,
-0.010348009,
-0.018681018,
0.025012022,
-0.020280018,
-0.0010066885,
-0.027872026,
-0.022802021,
0.007943007,
0.0039260034,
-0.0051610046,
0.0073060067,
-0.013084512,
-0.013494012,
0.006630006,
-0.04243204,
-0.012883011,
0.0008072195,
0.019591017,
0.0014105013,
0.006006005,
-0.029198026,
0.022607021,
0.018187016,
0.014690014,
0.012785511,
-0.006246506,
0.009776009,
0.036920033,
0.0019743768,
0.0007194694,
-0.025454022,
-0.024570022,
0.007884507,
0.007891007,
-0.02106002,
-0.0112840105,
0.02232102,
0.03302003,
-0.006626756,
-0.035334032,
0.018967018,
-0.028288025,
-0.009808509,
0.012766011,
0.008300507,
0.0036205032,
0.005937755,
0.010744509,
-0.019578017,
-0.007839007,
-0.015847014,
-0.00068128185,
0.026988024,
-0.010094509,
-0.02180102,
0.016445015,
0.0042737536,
-0.030238027,
0.015483014,
-0.011622011,
-0.015704013,
0.0015201889,
0.03455403,
-0.0010253759,
-0.008677508,
0.03632203,
0.009340509,
-0.012538511,
-0.004046254,
0.0052292547,
0.029952027,
0.0036855033,
-0.027508024,
0.008775008,
0.016536014,
-0.017030016,
-0.038610034,
0.008801008,
-0.016536014,
0.039780036,
0.0003895941,
-0.026026024,
-0.058136053,
-0.0018687517,
-0.0053105047,
0.0015591889,
0.0074685067,
-0.0053300047,
-0.014157013,
-0.005996255,
-0.015665013,
0.005655005,
0.05772005,
-0.03151203,
-0.004598754,
0.0021710019,
-0.008898508,
-0.00050293794,
-0.018486017,
-0.00046921917,
-0.020332018,
0.010107509,
-0.026130024,
-0.029042026,
-0.023764022,
-0.009210508,
0.019617017,
0.007475007,
0.017381016,
0.0011505011,
-0.012948012,
0.013858013,
0.012714012,
0.00079096947,
0.005573755,
-0.00012126574,
-0.015080013,
0.018720018,
-0.0060092555,
0.004449254,
0.013136512,
-0.0014933763,
0.025857024,
-0.014118013,
0.012915512,
-0.0059215054,
-0.026754024,
-0.013182011,
0.0063375058,
-0.008502007,
-0.007494507,
0.0057525053,
-0.038870037,
-0.018525017,
0.030862028,
0.013559012,
0.006366756,
-0.0028616276,
-0.019747017,
-0.03426803,
0.016224016,
0.026507024,
0.005668005,
-0.0071565066,
-0.017992016,
-0.017355016,
0.010387009,
0.024648022,
0.014313013,
-0.0026211273,
0.0140270125,
0.0029965027,
-0.02250302,
0.02247702,
-0.01183001,
0.021398019,
-0.029172026,
-0.030576028,
0.017225016,
-0.0058727553,
-0.0070720064,
-0.012980511,
0.014638013,
0.009958009,
-0.030238027,
0.012935012,
-0.033956032,
0.018928017,
-0.00032337528,
-0.03273403,
-0.004306254,
-0.027404025,
0.025363022,
0.007455507,
-0.005538005,
0.005326755,
-0.024687022,
-0.0014064388,
0.0058500054,
0.02232102,
0.013143011,
-0.025272023,
0.017732017,
-0.008326507,
0.014118013,
-0.027612025,
-0.017394016,
0.0071435063,
-0.0026861273,
-0.014001013,
-0.017875016,
-0.02402402,
-0.028002026,
0.016887015,
0.010361009,
-0.012363011,
0.011908011,
-0.015249014,
-0.009171508,
0.031252027,
-0.017459016,
0.019903017,
0.012337011,
-0.014872014,
0.0007682194,
0.0047417544,
-0.028730026,
-0.013910012,
-0.0029282526,
0.013728012,
0.004725504,
0.02174902,
0.003142753,
0.00025187523,
-0.00013071105,
-0.0029835026,
-0.014950014,
0.03325403,
-0.0038707536,
0.015210014,
0.025987023,
-0.03351403,
0.027508024,
-0.00025106274,
-0.020878019,
-0.019461017,
-0.009951509,
-0.014911014,
0.014716013,
0.015639015,
-0.02206102,
0.018460017,
-0.012915512,
-0.009925509,
-0.015431014,
-0.02067002,
0.0070330063,
-0.02386802,
-0.015574014,
-0.004088504,
0.012077011,
0.0025171272,
0.012428011,
0.0029087525,
0.016640015,
0.011888511,
-0.0072150063,
0.021645019,
0.0041047535,
0.016380014,
-0.020280018,
0.013520013,
-0.017875016,
-0.015210014,
-0.004381004,
0.0015405014,
-0.061984055,
-0.035074033,
-0.0130390115,
-0.0004420004,
0.016731014,
0.016302014,
0.018083015,
0.00046840668,
0.0005281255,
0.0074035064,
-0.02291902,
-0.0049757543,
-0.02258102,
-0.003269503,
0.02167102,
-0.014144013,
-0.006896506,
-0.021281019,
0.030550027,
0.0063505056,
-0.02302302,
-0.008859508,
-0.03135603,
0.030316027,
-0.015158013,
0.0011870635,
-0.008710008,
0.0061522555,
-0.012044511,
0.03559403,
0.013377012,
-0.014443013,
-0.015093014,
0.020267019,
0.035802033,
-0.002044252,
-0.0031687529,
0.008021007,
-0.0047905045,
0.009119508,
-0.025792023,
-0.027846025,
0.004491504,
0.019695017,
0.014625013,
-0.018707016,
-0.018291017,
-0.024271023,
-0.05605605,
0.004907504,
-0.012207011,
0.02180102,
0.008437008,
-0.000085261796,
0.0030501278,
0.013279512,
0.008118507,
0.0027332525,
-0.009444509,
-0.024193022,
0.019123018,
-0.0036595033,
0.019695017,
-0.0065812557,
-0.03406003,
0.0020345019,
0.020592019,
-0.018642018,
-0.014105013,
0.005957255,
0.0055412548,
0.016978016,
-0.007702507,
0.02238602,
-0.0046540042,
-0.026130024,
0.0017078766,
-0.03330603,
-0.0050472547,
0.0011960011,
-0.0068120062,
-0.0076505067,
0.0037082534,
0.014742013,
-0.02277602,
0.004481754,
-0.025571022,
-0.02217802,
-0.017017016,
-0.007943007,
0.00070240686,
-0.013045512,
-0.009984009,
0.023738021,
-0.015535014,
0.0019028767,
-0.00090837583,
-0.0013089387,
-0.0009124383,
-0.025103023,
0.015431014,
-0.019695017,
-0.001105001,
0.014339013,
0.0081575075,
0.0068120062,
0.018733017,
-0.0042705038,
-0.0021060018,
-0.006587756,
0.0025285024,
-0.004306254,
-0.024557022,
-0.0062432555,
0.014950014,
-0.0025187524,
-0.0024748773,
-0.024674023,
0.015366014,
-0.008898508,
0.0059020054,
0.004504504,
-0.02194402,
0.009295008,
-0.004540254,
-0.0039032535,
-0.002276627,
0.025012022,
0.20248818,
0.003386503,
-0.003373503,
0.028470026,
-0.009288508,
0.017563015,
0.039234035,
0.017953016,
-0.013923013,
0.014573013,
0.026910024,
0.0048782546,
-0.02262002,
0.003313378,
0.015704013,
0.0015080014,
-0.03226603,
-0.03320203,
0.025558023,
-0.03543803,
-0.013858013,
0.007572507,
0.002343252,
-0.02338702,
0.004530504,
0.0072475066,
-0.005567255,
0.0015494389,
0.039208036,
0.002273377,
-0.008807508,
-0.002463502,
0.032682028,
0.0044720042,
0.002044252,
-0.02178802,
-0.017680015,
0.0009888133,
0.0014210638,
0.0061035054,
-0.01047151,
0.004797004,
-0.03190203,
-0.0031703778,
0.001106626,
0.036426034,
0.009314508,
-0.024934022,
-0.0091455085,
-0.0009985634,
-0.032188028,
-0.015769014,
0.007605007,
0.0062400056,
-0.013780013,
0.0025480024,
0.025272023,
0.020657018,
-0.013923013,
0.020527018,
-0.00018382829,
-0.0017160015,
-0.01098501,
0.030732028,
-0.017680015,
0.015691014,
-0.017433016,
0.025948023,
-0.0018135016,
-0.0037602533,
-0.0050732545,
-0.014742013,
-0.016419014,
0.0030257527,
-0.0007564382,
-0.01171301,
0.0025041273,
0.015522014,
0.0026292524,
0.037648033,
-0.012480011,
-0.010725009,
0.0015656889,
0.019851018,
-0.018161016,
-0.017420016,
0.0008953758,
0.01054951,
-0.028964026,
0.013780013,
0.011680511,
-0.012317511,
-0.024141021,
-0.0059410054,
0.022932021,
0.0059735053,
-0.0017208765,
-0.013390012,
-0.0010383759,
0.009334008,
-0.020176018,
0.10218009,
-0.019435018,
0.02249002,
-0.0012390636,
-0.012883011,
-0.0012642512,
0.0140270125,
-0.009067508,
-0.014196013,
0.0020198768,
-0.052598048,
-0.0030127526,
-0.011524511,
-0.01131001,
0.037050035,
0.014820013,
-0.018434016,
0.010400009,
-0.021008018,
0.009607009,
-0.015795015,
0.006799006,
0.043524038,
0.0019467517,
-0.017628016,
0.0019906268,
-0.02330902,
0.0010668135,
-0.017290015,
-0.0056810053,
-0.001620939,
0.0057330052,
-0.02163202,
-0.015171014,
0.008216008,
0.007566007,
-0.010640509,
0.0018151266,
0.019734018,
0.024336021,
-0.02323102,
0.026676023,
0.008489008,
0.016640015,
-0.017004015,
-0.013195012,
-0.001643689,
0.00091812585,
-0.010764009,
0.008326507,
0.008781508,
0.03361803,
-0.01094601,
0.01173251,
-0.013286012,
0.007871507,
-0.025220023,
-0.01073151,
0.008086007,
-0.029978028,
-0.0059702555,
0.02259402,
0.0093080085,
-0.012350011,
0.00076253194,
-0.16265614,
0.02030602,
0.016731014,
0.008144507,
0.002244127,
-0.009561509,
0.042822037,
0.008346007,
-0.006415506,
0.01135551,
0.026650025,
-0.013273012,
-0.015821014,
-0.017706016,
0.030524027,
0.010783509,
0.0006455318,
0.016016014,
0.013546012,
0.009314508,
0.009594008,
-0.0012415011,
0.019968018,
-0.007813007,
0.006786006,
-0.019045018,
-0.007657007,
0.036686033,
-0.013962013,
0.005827255,
-0.016757015,
-0.009210508,
0.040274035,
0.014183013,
-0.020540018,
0.009763009,
-0.020605018,
-0.015483014,
-0.01147901,
0.017446015,
0.021086019,
0.015210014,
0.0040852535,
0.0061132554,
-0.008424007,
0.019890018,
0.010283009,
-0.037284035,
-0.020033019,
-0.011908011,
0.025896024,
-0.02173602,
-0.006613756,
-0.0009140633,
0.016146015,
0.0053300047,
-0.012499511,
0.013169012,
0.018889017,
-0.010406509,
-0.007605007,
-0.00013650012,
0.020761019,
0.018213017,
0.017381016,
-0.032604028,
-0.002107627,
-0.0027283775,
-0.03567203,
0.037986033,
-0.02237302,
-0.009587509,
-0.016822016,
0.00023420334,
0.016640015,
0.02038402,
0.013663013,
0.01179101,
-0.015366014,
0.02291902,
-0.0053820047,
-0.004195754,
-0.016692014,
0.0053430046,
-0.013416012,
0.013292512,
0.022724021,
0.016666016,
0.03338403,
-0.019812018,
0.01073151,
-0.040092036,
0.016328014,
-0.02106002,
0.001116376,
-0.00059881306,
-0.008489008,
0.0049725045,
0.016705016,
-0.017056016,
0.008105507,
-0.0069680065,
-0.010543009,
-0.013481013,
0.023322022,
-0.024102021,
-0.0009490009,
0.008073008,
0.0150150135,
-0.013416012,
-0.009620009,
0.015457014,
0.0065000057,
0.027976025,
0.01179101,
0.018083015,
0.0016656265,
-0.0104975095,
-0.0013901887,
0.0004663754,
0.052468047,
0.006675506,
-0.027014025,
0.026221024,
-0.013065012,
-0.014404013,
-0.107328095,
-0.024700021,
0.023712022,
-0.017888017,
0.009373008,
0.018772017,
0.0064122556,
0.004264004,
0.008372008,
0.010029509,
-0.009841009,
-0.01201201,
-0.006464256,
-0.013260012,
0.027300024,
0.000029224635,
0.014846013,
-0.019500017,
-0.034918033,
0.03598403,
-0.0140270125,
-0.013741013,
-0.01112151,
-0.017706016,
-0.006357006,
0.012135511,
-0.0071175066,
0.014274013,
0.0013406262,
0.029614026,
0.02111202,
0.014729014,
0.006682006,
0.017472016,
0.003243503,
-0.0039942535,
0.00062643806,
-0.02321802,
0.025207022,
-0.038662035,
0.0064805057,
0.017134015,
0.026039023,
-0.008768508,
0.03348803,
-0.0036985034,
-0.012740011,
-0.00083200075,
0.01167401,
-0.0018931268,
-0.011908011,
-0.027586024,
-0.016588015,
0.004205504,
-0.0048295045,
-0.026351023,
0.024115022,
-0.012987012,
-0.018759016,
-0.017901016,
0.01105651,
-0.00032642216,
-0.02163202,
-0.008060007,
0.008651508,
-0.017316015,
-0.011583011,
-0.0050277547,
0.005986505,
-0.045942042,
-0.03364403,
-0.0050147544,
-0.019851018,
0.013429012,
-0.031486027,
0.024297021,
-0.009587509,
-0.018135017,
0.003523003,
0.013403012,
-0.04388804,
0.00081087573,
0.017602015,
0.020280018,
0.006701506,
0.002262002,
-0.009763009,
0.0013576887,
-0.0071305064,
-0.038636036,
-0.0035945033,
0.022724021,
0.0019727517,
0.000019042986,
0.0070395065,
0.02155402,
-0.00085475075,
-0.012038011,
0.02067002,
0.000020084002,
-0.0025707523,
-0.012668512,
-0.049868044,
0.0091260085,
0.025766023,
0.026754024,
-0.01191451,
-0.0008376883,
0.024830023,
-0.016016014,
0.009347009,
-0.024739021,
0.009204009,
0.009789009,
0.01088751,
-0.0053917547,
-0.03185003,
-0.012018511,
0.037986033,
-0.020241018,
0.028210025,
0.014118013,
0.007806507,
0.004514254,
0.013104012,
0.043524038,
0.008762008,
-0.0016623765,
0.0033800032,
0.0076700067,
-0.017420016,
0.00007053522,
0.021645019,
-0.02265902,
-0.010224509,
0.0047320044,
-0.016315015,
-0.01055601,
0.009483509,
0.018213017,
0.00004390043,
0.012844011,
-0.0075790067,
-0.025311023,
0.0034255031,
-0.030108027,
0.014937013,
-0.013728012,
-0.039026037,
0.027950024,
0.014053012,
-0.0118495105,
0.0027820026,
0.0012886261,
-0.0061912555,
-0.038428035,
-0.04196404,
0.017394016,
0.01098501,
0.017277015,
0.0011350635,
-0.0063602556,
0.012096511,
-0.007475007,
-0.004329004,
-0.00030448465,
0.009756509,
-0.018590016,
-0.00006474615,
-0.0021563768,
0.025233023,
0.0038707536,
-0.0087035075,
-0.013663013,
-0.0018525016,
0.010783509,
0.0039292537,
-0.018460017,
-0.02282802,
0.02375102,
-0.03299403,
-0.0045825043,
-0.004459004,
-0.018005015,
-0.011544011,
0.018993016,
0.007949507,
0.009438008,
-0.03520403,
0.024869023,
-0.0071175066,
-0.0063635055,
-0.0060645053,
-0.006779506,
0.0009725634,
0.018876016,
0.016523015,
0.04149604,
-0.014508013,
-0.018317016,
0.0025561273,
0.027196024,
0.014378013,
0.01160901,
-0.013572012,
-0.02258102,
0.01140751,
0.007962507,
-0.0029965027,
-0.02255502,
-0.03361803,
0.027222024,
0.01164801,
0.0050667548,
0.018031016,
0.0036465032,
0.0017452516,
0.004403754,
-0.020150019,
0.002158002,
0.006883506,
0.02321802,
-0.0032045029,
-0.0013373762,
0.024453022,
0.0050375047,
0.051194046,
-0.0052325046,
0.028340025,
-0.0047807544,
0.02121602,
0.029588027,
-0.0046410044,
0.0043517537,
-0.02121602,
-0.013793012,
-0.009620009,
-0.036426034,
-0.008827008,
0.015275014,
-0.009951509,
0.05501605,
-0.01065351,
-0.02074802,
-0.0098930085,
0.029276026,
0.009516008,
-0.014443013,
0.015587014,
-0.05543205,
-0.019734018,
-0.002213252,
-0.0138450125,
0.02252902,
-0.04797004,
-0.01157001,
0.02229502,
0.0110435095,
0.012603511,
0.0049692546,
-0.024219021,
0.012161511,
-0.024687022,
0.02386802,
-0.018122016,
-0.020176018,
-0.025168022,
0.020501018,
-0.0120315105,
-0.02338702,
-0.02171002,
0.0068510063,
0.007865007,
-0.02098202,
-0.014846013,
0.020098018,
-0.004364754,
-0.031876028,
-0.0078000072,
0.017368015,
-0.0062985057,
-0.011726011,
0.027040025,
-0.030680027,
0.002393627,
-0.024505023,
-0.016588015,
-0.016900016,
-0.0013000012,
-0.022880021
] |
How individual cells respond to mechanical forces is of considerable interest to biologists as force affects many aspects of cell behaviour. The application of force on integrins triggers cytoskeletal rearrangements and growth of the associated adhesion complex, resulting in increased cellular stiffness, also known as reinforcement. Although RhoA has been shown to play a role during reinforcement, the molecular mechanisms that regulate its activity are unknown. By combining biochemical and biophysical approaches, we identified two guanine nucleotide exchange factors (GEFs), LARG and GEF-H1, as key molecules that regulate the cellular adaptation to force. We show that stimulation of integrins | [
-0.02671289,
0.010140022,
-0.005464603,
-0.002019383,
-0.009337574,
0.015531676,
-0.0136615075,
0.0038099692,
-0.0138206715,
-0.029020756,
0.018927157,
-0.0061112037,
0.0049605863,
0.0056900843,
-0.004619049,
-0.007089394,
0.030904189,
0.011008788,
-0.016340755,
0.014510378,
-0.017216153,
0.01738858,
0.003717124,
-0.041355904,
-0.032177493,
0.027057745,
0.017521216,
-0.039260257,
0.0022117053,
-0.027243434,
-0.00034796225,
0.012985065,
-0.03467105,
0.00059478957,
-0.017932387,
-0.0019049846,
0.01425837,
-0.007600043,
0.005640346,
-0.0007187213,
0.01473586,
0.012096403,
0.0010726936,
-0.010935838,
-0.003743651,
0.0025383215,
0.003087103,
-0.020585107,
-0.010445085,
0.019696446,
0.013508976,
0.026222138,
-0.016261173,
-0.0024753194,
-0.00729498,
-0.029232975,
0.01473586,
0.016287701,
0.018462932,
-0.043557663,
-0.022521593,
0.017282471,
-0.029259501,
0.0037933895,
-0.009496737,
0.024895778,
0.008249959,
0.012898851,
0.007971424,
-0.002055858,
0.024617242,
0.03127557,
-0.0044930447,
0.014828704,
0.021871677,
-0.03445883,
-0.015040922,
-0.0044565694,
-0.002651062,
0.016420336,
-0.013217177,
-0.009821696,
0.015186822,
0.04262921,
-0.01271316,
-0.0028069094,
-0.010703725,
0.0055939234,
-0.0010660619,
-0.004211193,
-0.008031109,
0.016155064,
0.008064269,
0.022561384,
-0.007891842,
0.005623766,
-0.011904081,
0.0036905967,
-0.0082168,
-0.01212293,
-0.0029412033,
-0.00026547923,
0.008913139,
-0.02107586,
-0.015929583,
-0.017945651,
0.02409996,
-0.010823098,
0.006870545,
-0.018635359,
-0.04469833,
0.018515985,
-0.0048146867,
-0.015054186,
0.022839919,
-0.01742837,
0.021513559,
0.016407073,
0.0030754972,
-0.0031683424,
0.006790963,
0.022282848,
0.028331049,
-0.0059851995,
0.040851887,
0.0049871136,
0.0037900738,
0.007938265,
-0.02774745,
-0.011141424,
0.010584353,
-0.011028684,
0.0012219092,
0.034140505,
-0.023410253,
-0.0005972765,
0.000662351,
-0.008933035,
-0.014284898,
-0.01577042,
0.013953307,
0.016659081,
-0.025399795,
0.0030075214,
-0.009330942,
0.01691109,
0.031991802,
0.021500295,
0.010531299,
-0.0041084,
0.0067710676,
0.0052888603,
0.007029708,
0.006916967,
0.004509624,
0.010975629,
-0.02542632,
0.030904189,
-0.008627972,
-0.018210923,
0.011857659,
0.0011050237,
0.016937617,
0.022773601,
0.021274814,
0.01838335,
-0.003082129,
0.0002350144,
0.015836738,
-0.008873348,
0.0062736827,
0.015637785,
-0.003713808,
0.015239877,
0.025214104,
0.008110692,
0.013024855,
0.013701299,
-0.017003935,
0.0008820294,
0.0010204682,
0.0020011456,
0.02719038,
-0.0056934003,
0.0023990537,
-0.02059837,
0.03069197,
0.006804227,
0.022428747,
-0.026779208,
-0.0198954,
0.00909883,
-0.0052623334,
-0.020651424,
-0.6302863,
-0.003975764,
0.030532807,
-0.0036010675,
-0.00048204896,
0.02037289,
0.009151884,
-0.004997061,
-0.008899876,
0.021115651,
-0.017746696,
0.023569416,
0.022640966,
-0.016831508,
-0.024338705,
-0.03032059,
-0.0034120611,
-0.028914647,
0.02880854,
0.00497385,
-0.017030463,
-0.0011481304,
-0.0012898851,
0.022534857,
0.025373267,
0.008349436,
0.026182346,
0.0013056357,
-0.011161319,
0.04697967,
-0.016552974,
0.02424586,
-0.010014018,
0.011738286,
0.04445959,
-0.0041581388,
-0.015505148,
0.0334508,
0.014603224,
0.020067826,
-0.025054941,
-0.0064494256,
0.01676519,
-0.0028831752,
-0.0063731596,
-0.0019696446,
0.0032263708,
-0.0066616433,
-0.002026015,
-0.0019514072,
-0.017521216,
0.017163098,
-0.0269649,
-0.00011761083,
0.024603978,
-0.010743516,
0.026222138,
0.0038398122,
-0.0027090902,
0.005965304,
0.017733432,
0.016659081,
-0.034511887,
-0.023198036,
-0.014881759,
0.014444061,
-0.012905483,
0.027017953,
0.00076141354,
0.026447618,
0.020717744,
0.010968997,
-0.0037867578,
0.0025267159,
0.006638432,
0.048836574,
-0.010378767,
0.0370585,
-0.012626947,
0.011592386,
-0.0034319565,
-0.0017524532,
-0.009443684,
0.013024855,
0.016818244,
0.013329918,
-0.03326511,
0.012626947,
-0.004542783,
-0.016115274,
0.017176362,
0.009165147,
-0.018449668,
-0.0428149,
-0.008601445,
0.019179165,
-0.0030108371,
0.009503369,
0.009662532,
-0.0042476677,
-0.0014639698,
-0.004214509,
0.007726047,
0.00065240334,
0.0063167894,
0.008177009,
-0.03249582,
0.02431218,
0.03570561,
-0.032124437,
-0.009861487,
-0.0035645925,
-0.021420714,
0.014510378,
-0.010014018,
-0.026208874,
-0.0005471235,
0.016659081,
0.009702323,
-0.041249797,
0.019364856,
-0.005275597,
-0.0000833638,
-0.007964792,
0.023171509,
0.008336172,
-0.018794522,
-0.014563433,
-0.011446487,
0.005438076,
0.011645441,
-0.0005612161,
0.019391384,
-0.01587653,
0.022375694,
0.013807408,
0.00887998,
0.009291152,
0.0030920766,
-0.029736992,
-0.04819992,
-0.009735483,
0.03440578,
-0.027455652,
-0.031673476,
-0.0057166116,
-0.034167033,
-0.0041581388,
0.023304146,
-0.013256968,
0.01577042,
-0.0009831643,
-0.008820294,
0.009490105,
0.021168705,
-0.004005607,
-0.01753448,
-0.014006361,
0.008760608,
-0.03127557,
-0.0030688655,
-0.0041946135,
-0.015173558,
-0.008157114,
-0.011744917,
-0.0065124277,
-0.0059918314,
0.00024371865,
0.0011705126,
-0.030161425,
0.016380547,
-0.033477325,
-0.032787617,
0.025028413,
-0.0025316896,
0.024471343,
-0.012693265,
0.01215609,
-0.009582951,
-0.025452849,
0.014656278,
-0.03180611,
-0.0104251895,
-0.009602847,
0.023569416,
0.0027638027,
0.02530695,
0.022296112,
0.0021652826,
0.028092304,
-0.0136615075,
0.0012136194,
-0.01919243,
0.007964792,
0.0030556018,
-0.026116028,
0.008826925,
0.010896048,
0.000017784105,
0.03658101,
0.0115525955,
-0.01937812,
0.018821048,
-0.013097805,
0.014152261,
0.007261821,
-0.0054944465,
-0.022428747,
0.031222515,
-0.0046886825,
0.0018104814,
0.015345985,
0.0042410363,
-0.005574028,
0.010531299,
-0.004005607,
-0.009052407,
0.026142556,
-0.019868873,
-0.008276487,
-0.005109802,
-0.007905105,
0.036289208,
-0.002820173,
-0.005282229,
0.0138206715,
0.0045295195,
0.02070448,
-0.017507952,
-0.013038118,
-0.00947021,
0.02520084,
0.015491885,
0.008170377,
-0.0071026576,
-0.006754488,
-0.005235806,
-0.0036441742,
0.027773978,
-0.012083139,
0.025612012,
0.01359519,
0.00002823696,
0.010657302,
0.008269855,
-0.003710492,
0.014722596,
0.016473392,
-0.02103607,
0.02287971,
-0.0049274275,
0.035095487,
-0.019842345,
-0.001856904,
-0.0073414026,
-0.006797595,
0.01525314,
0.013940044,
0.038703185,
-0.0026112713,
0.00703634,
0.019776028,
0.0055541326,
-0.010073704,
-0.005772982,
0.018303769,
0.011897449,
0.014868496,
-0.021155441,
0.009178411,
-0.019245483,
-0.003912762,
0.01577042,
-0.009669164,
0.017627325,
0.006200733,
0.02402038,
-0.020638162,
0.0018452983,
0.00019087149,
0.010126758,
-0.030904189,
0.018728202,
0.011492909,
-0.013097805,
0.005371758,
-0.019882137,
0.047483686,
-0.027071007,
0.011028684,
0.007255189,
0.007427616,
0.007759206,
-0.0013155834,
-0.010411926,
-0.0017474793,
0.014099207,
-0.009563056,
0.027110798,
-0.0060183583,
0.019431174,
-0.016075483,
-0.0076796245,
-0.017375316,
0.057245698,
0.014483851,
-0.009821696,
-0.029736992,
0.0062803146,
-0.044645276,
0.002816857,
0.013608454,
0.004008923,
-0.016924353,
0.00008294931,
0.0078387875,
0.024259124,
-0.0167254,
0.056449883,
-0.022906236,
-0.013343181,
-0.021898203,
0.0035347494,
-0.020001508,
0.034299668,
0.021831885,
-0.011327114,
0.018927157,
-0.0069832853,
0.0009632689,
0.006804227,
-0.018515985,
0.0039227097,
-0.027800506,
0.0019381435,
-0.017799752,
0.022906236,
-0.0013338208,
-0.008913139,
0.029975737,
0.0036309105,
-0.008090796,
0.0007199648,
0.013363077,
0.010670566,
0.019391384,
0.032522347,
0.029949209,
0.02715059,
0.013701299,
-0.022123685,
0.019882137,
-0.020664688,
-0.010431821,
0.0035844878,
0.0015336038,
0.0040652934,
0.013389604,
-0.024935568,
-0.038252223,
-0.0039591845,
0.000033236716,
-0.0011050237,
0.0009541502,
-0.0038199169,
-0.000066110755,
-0.007354666,
-0.004479781,
0.0045825737,
-0.011811236,
0.012958537,
0.01304475,
-0.023184773,
-0.004370356,
0.01348245,
-0.039764274,
0.02022699,
-0.017972179,
0.0076398337,
-0.019112848,
-0.0019165901,
-0.0051960154,
-0.0059155654,
-0.039392892,
-0.026792472,
-0.005116434,
0.023423517,
-0.03307942,
0.00028371668,
-0.009238098,
-0.01160565,
-0.020425944,
-0.017070252,
-0.012408098,
-0.0022979188,
-0.057245698,
-0.03713808,
0.008601445,
0.028967703,
0.009848223,
0.02026678,
-0.00068763475,
-0.006804227,
-0.003153421,
0.0060183583,
-0.0035546448,
-0.018330295,
-0.029710464,
-0.0097819045,
0.012394834,
-0.0015534991,
0.0005898157,
0.011174583,
-0.008462177,
0.006399687,
-0.018781258,
0.0337426,
-0.007420984,
0.0064262142,
0.007911737,
0.009005984,
-0.0062537873,
0.007394457,
0.000281437,
-0.0112342695,
-0.040480506,
-0.003654122,
-0.014271634,
-0.017693643,
0.0059487247,
0.0068506496,
0.006167574,
-0.015690839,
-0.01407268,
-0.011844395,
-0.024338705,
0.008986089,
-0.003317558,
0.00024889974,
0.013575295,
0.007871946,
0.009490105,
0.002621219,
-0.013303391,
0.01013339,
-0.02240222,
0.011943872,
0.013913516,
-0.02258791,
-0.0008919771,
-0.0116786,
-0.01705699,
-0.031010296,
-0.0120433485,
-0.013727826,
0.02917992,
0.019218957,
-0.028835066,
-0.023556154,
-0.011293955,
-0.03636879,
0.009397261,
-0.012646843,
-0.02586402,
-0.009005984,
-0.0013321628,
0.003120262,
-0.022640966,
0.014974604,
-0.037005443,
-0.010975629,
0.020120881,
-0.016751926,
0.016964145,
-0.018993475,
-0.004005607,
-0.012779479,
-0.01267337,
-0.03610352,
-0.037376825,
0.00049489806,
-0.0039525526,
0.039631635,
0.024418287,
0.04188645,
0.012540733,
0.0139798345,
0.013873725,
0.007427616,
-0.0013379656,
0.009987491,
-0.0010577721,
-0.021155441,
0.028888121,
0.019099584,
0.023503099,
0.033371218,
-0.01653971,
0.0031898958,
-0.002685879,
-0.009821696,
-0.03729724,
-0.005700032,
-0.026447618,
-0.009231466,
0.021937994,
0.0033871918,
-0.016818244,
-0.034936324,
-0.02126155,
-0.0010793254,
0.0049572703,
0.0023410253,
-0.0110751055,
0.00030195413,
-0.0035745401,
0.038331803,
-0.011758181,
0.019815817,
-0.0040354505,
-0.015704103,
0.0051993313,
-0.0071490803,
0.013203913,
-0.0003102439,
0.01790586,
0.00987475,
0.009821696,
-0.027402598,
-0.011996926,
-0.012514207,
-0.023370463,
-0.023065401,
-0.034326196,
-0.0037768101,
-0.02663331,
0.00009735275,
-0.029392138,
-0.009974227,
0.011738286,
-0.018542513,
0.024524396,
0.0072220303,
0.008031109,
0.026248664,
0.018250713,
0.013422763,
-0.012355044,
0.014775651,
0.007527093,
-0.0028665955,
-0.016804982,
-0.015531676,
-0.0003098294,
0.015956111,
0.035599504,
0.0020774114,
-0.010458348,
-0.029551301,
-0.0030456542,
-0.0123683065,
-0.008475441,
-0.0067080655,
0.025956865,
0.015929583,
0.013343181,
-0.0075801476,
-0.013217177,
-0.030347116,
0.0025747963,
0.007420984,
0.012553997,
0.00029014124,
-0.015425567,
-0.027906613,
0.021818621,
0.015200086,
0.0061178356,
-0.0036905967,
-0.024802933,
-0.0020392784,
-0.004871057,
-0.0053551784,
0.011585754,
-0.005394969,
0.0016115274,
0.0165795,
-0.0030274168,
0.012222407,
0.006698118,
0.0050302204,
-0.018622095,
-0.00769952,
0.04045398,
-0.025360003,
-0.023131719,
0.0036375422,
-0.003485011,
0.01496134,
-0.007593411,
-0.003312584,
0.024046907,
-0.031673476,
-0.0019033266,
0.008409122,
-0.0063499487,
-0.010153286,
-0.00086959475,
-0.015982637,
-0.013230441,
-0.024192806,
-0.01053793,
-0.007653097,
-0.03448536,
-0.024391761,
0.0031981855,
0.027667869,
0.029312557,
0.0016131854,
0.0076796245,
-0.008429018,
0.029392138,
-0.036448374,
0.030294063,
0.010405295,
-0.0034286405,
-0.020757534,
0.011499541,
-0.012262198,
-0.018781258,
0.00762657,
-0.011194479,
-0.029153394,
-0.0036640696,
-0.019630129,
0.006396371,
0.0038331803,
-0.008024478,
0.01061088,
0.0046853665,
0.016950881,
0.013886989,
0.0019795923,
-0.020200463,
-0.0057762978,
-0.0013727826,
0.034352724,
-0.039923437,
-0.0027090902,
0.03193875,
-0.0051926994,
-0.0023310776,
-0.010365503,
-0.011797972,
-0.019921927,
0.00092099124,
-0.015544939,
-0.009629373,
-0.007460775,
-0.013886989,
-0.023450045,
0.027017953,
0.010491507,
-0.013542135,
-0.0019746185,
0.0069368626,
0.0232113,
0.010113495,
-0.015903056,
0.0024720035,
0.031700004,
-0.0026278507,
-0.033185527,
-0.0058127725,
-0.007971424,
0.03533423,
0.017998705,
-0.018701676,
-0.022892974,
0.004997061,
-0.03729724,
-0.029312557,
0.008322909,
-0.0068506496,
-0.0053253355,
-0.008820294,
-0.005845932,
0.012447889,
0.008230064,
0.008462177,
0.019139376,
0.00044267264,
0.012985065,
-0.023476573,
0.0020011456,
0.018794522,
-0.029604355,
0.0013396236,
0.03987038,
-0.01852925,
-0.008475441,
0.010385399,
0.013343181,
0.022946028,
-0.01201019,
0.018184396,
0.008037741,
0.022534857,
0.04294754,
-0.022932764,
-0.0132636,
0.0099410685,
0.005003693,
-0.006897072,
0.027986197,
-0.020969752,
-0.00225647,
0.014643014,
0.012315253,
-0.019484228,
0.017879333,
-0.020479,
0.034087453,
-0.009271257,
-0.002921308,
0.0102593945,
0.007593411,
0.0031998435,
0.0016529761,
-0.004549415,
-0.008442282,
0.0068108584,
0.0025316896,
-0.020850379,
-0.01002065,
0.00795816,
0.008468809,
-0.024338705,
-0.0049705342,
-0.0054778666,
0.00012652231,
-0.011870922,
0.0056204507,
0.00543476,
0.0041282955,
-0.027773978,
-0.024882514,
-0.02590381,
-0.040719252,
0.0011398406,
-0.011426591,
-0.016035693,
-0.011990295,
0.034087453,
-0.0041349274,
0.011851027,
0.0006735422,
0.004778212,
-0.009708955,
0.016818244,
0.19757459,
-0.015226613,
0.00076472946,
-0.003985712,
-0.0196036,
-0.010743516,
0.0035015903,
-0.01798544,
0.0006329224,
0.0037569148,
0.023410253,
0.020479,
-0.008555022,
-0.004877689,
0.012726424,
0.0069899173,
-0.016234646,
0.0232113,
-0.0049639023,
0.013104437,
0.0035745401,
0.010776675,
-0.0058393,
0.006638432,
0.053664524,
-0.022428747,
-0.019683182,
-0.017468162,
-0.017587533,
-0.0034750632,
-0.018290505,
0.008455545,
-0.009536528,
0.016354019,
0.0031882378,
0.012912114,
0.0009997438,
0.005799509,
0.013940044,
0.0018021916,
0.0029080443,
-0.010411926,
-0.014085943,
0.0024338707,
0.015093977,
0.010484876,
-0.0034153769,
-0.011254164,
-0.008382595,
0.023781635,
-0.057988457,
0.0051495926,
-0.0017856122,
0.04472486,
0.006754488,
-0.019961718,
0.006897072,
0.013508976,
-0.0066715907,
0.014908287,
-0.026832262,
0.0074010887,
-0.013442659,
0.024603978,
-0.03610352,
0.011386801,
-0.021619668,
0.019842345,
0.002917992,
-0.022190003,
-0.0049207956,
0.000165795,
-0.021646196,
0.012540733,
-0.039339837,
-0.008356068,
0.037376825,
-0.005832668,
0.024298916,
0.023171509,
0.017852806,
0.0018005337,
-0.0370585,
-0.0016007507,
-0.0077194152,
-0.024630506,
0.017375316,
0.013051382,
-0.013555399,
-0.014112471,
0.01374109,
-0.0045162556,
-0.011154688,
-0.009178411,
0.008210168,
-0.01864862,
-0.031222515,
0.0022647597,
-0.028092304,
0.010557826,
-0.04774896,
0.077565536,
0.021845149,
0.0037635465,
0.0017872701,
-0.0023095245,
0.014298161,
0.013197282,
0.0006482584,
-0.016340755,
0.00020268439,
-0.0201872,
0.0032678195,
-0.025797702,
-0.010047177,
-0.0117183905,
0.031885695,
-0.023794899,
0.050136406,
-0.016712137,
-0.023277618,
-0.011141424,
0.00617089,
0.018927157,
-0.011300587,
-0.0024985305,
-0.017441634,
0.0024272387,
0.007248557,
-0.032787617,
0.0018320348,
0.02630172,
-0.00050526025,
-0.010637407,
0.0073480345,
0.0033905078,
0.015160295,
-0.022083893,
-0.023105191,
0.008893244,
-0.03124904,
-0.010325712,
0.029896155,
0.022892974,
-0.006028306,
-0.011585754,
0.016181592,
0.031036824,
-0.01890063,
-0.021500295,
0.0043902514,
-0.006230576,
-0.0005529263,
-0.015226613,
0.0077724694,
-0.008475441,
-0.01319065,
-0.02774745,
0.029763518,
0.0010726936,
-0.031222515,
0.003680649,
0.024696823,
-0.019444438,
-0.004778212,
-0.0072087664,
-0.1663786,
0.020054564,
0.017401842,
-0.02509473,
0.017799752,
0.015505148,
-0.0057597184,
0.023317408,
-0.0012882272,
0.0099344365,
0.016261173,
-0.011035315,
-0.022773601,
-0.029736992,
0.0015427225,
0.016314227,
-0.009569688,
0.0023476572,
0.004370356,
0.02553243,
0.0066516954,
-0.02936561,
0.010644039,
-0.012580524,
0.009834959,
0.003148447,
-0.0016289359,
-0.008601445,
-0.013223809,
-0.025917074,
0.011466382,
0.004449938,
0.037085027,
-0.010544562,
0.0062803146,
0.008044373,
-0.008860085,
0.0050567477,
-0.0068241223,
0.012474416,
0.05920871,
0.026235402,
-0.014284898,
0.017454898,
0.0011133134,
0.028914647,
0.0014979579,
0.003314242,
0.012839165,
-0.01738858,
0.025293685,
-0.029392138,
0.0097752735,
0.031302094,
0.044380005,
0.022388957,
-0.0008654499,
0.013581926,
-0.016804982,
-0.014510378,
0.003683965,
-0.0009044117,
0.04300059,
-0.008899876,
0.0018502722,
-0.015889794,
-0.008734081,
0.0104251895,
-0.021792095,
0.015319458,
-0.008157114,
0.0049009,
0.0012161063,
-0.01610201,
0.03437925,
0.023423517,
0.0024918988,
-0.0049837977,
0.0030688655,
0.009151884,
-0.019696446,
0.011134792,
-0.013077909,
-0.028835066,
-0.01823745,
0.008256591,
0.025598748,
0.015465357,
0.014284898,
0.016048957,
0.030187953,
-0.028092304,
-0.0077459426,
-0.018356822,
0.024816196,
0.013031487,
0.014298161,
0.00046671293,
-0.005235806,
0.0075138295,
0.015040922,
-0.014563433,
-0.0057597184,
-0.0008053492,
0.008866716,
-0.014576697,
-0.012255566,
-0.0016430285,
0.055866282,
-0.018515985,
-0.016194856,
0.0013661508,
-0.0109026795,
0.04443306,
-0.00617089,
0.04697967,
0.0062769987,
0.001724268,
-0.0036872807,
-0.025837492,
0.0638775,
-0.0034054292,
-0.011254164,
-0.003083787,
-0.0031434733,
-0.019351592,
-0.13072604,
-0.007261821,
0.018065022,
0.012089771,
0.01392678,
0.007905105,
0.00096907176,
0.020969752,
-0.0073347706,
0.014377742,
-0.033238582,
0.002354289,
0.0052623334,
-0.0059951474,
-0.004154823,
0.007493934,
-0.0040188706,
-0.027455652,
-0.017176362,
0.006635116,
-0.009841591,
-0.021062598,
-0.0016057246,
-0.0034319565,
0.0053651263,
0.021991048,
-0.028463686,
0.027906613,
0.0016048956,
-0.0025151102,
0.0027074323,
0.0034319565,
0.024670295,
-0.021818621,
-0.018476196,
-0.031673476,
-0.0032230548,
-0.020969752,
0.017773224,
-0.0035281177,
0.007984688,
0.0039724484,
0.017919123,
-0.009927805,
-0.01653971,
-0.01993519,
-0.001592461,
0.025612012,
-0.00008984016,
-0.01160565,
-0.012374938,
-0.021964522,
-0.03032059,
-0.026235402,
0.029816573,
-0.0026676415,
0.0067478563,
0.027827032,
-0.004675419,
0.014311424,
-0.009596215,
0.014762387,
-0.017216153,
-0.011446487,
0.02880854,
-0.006568798,
-0.021752303,
-0.03313247,
0.034087453,
-0.0035314334,
0.011784708,
0.02022699,
-0.015014395,
0.00060473726,
-0.021181969,
0.017481424,
-0.02464377,
-0.02557222,
0.021433977,
-0.003846444,
-0.006916967,
-0.019829081,
0.016552974,
-0.02354289,
0.03514854,
-0.0010055467,
-0.0030108371,
-0.000165795,
0.014377742,
-0.0073480345,
-0.041276325,
0.043796405,
0.022786865,
-0.01046498,
-0.0003224713,
0.016473392,
-0.038199168,
0.0065522185,
0.0077061513,
0.003514854,
-0.050534315,
-0.011890817,
-0.043743353,
0.011963767,
-0.018290505,
0.011565859,
0.009708955,
-0.019616865,
0.015743893,
-0.018104814,
0.020545317,
0.0014449034,
-0.007825524,
0.021898203,
0.015160295,
-0.027110798,
-0.026805736,
-0.024710087,
0.042231303,
-0.0063267373,
0.028304523,
0.017627325,
-0.007818893,
0.0013147544,
0.020054564,
0.016937617,
0.02147377,
-0.008070901,
-0.020651424,
0.0016944249,
-0.031434733,
0.0012103035,
0.01407268,
-0.05703348,
-0.023887744,
-0.0062504713,
-0.0021288078,
-0.026182346,
-0.01440427,
0.03326511,
0.018396612,
0.027959669,
-0.00022071459,
-0.03307942,
0.009483474,
-0.004008923,
0.014192052,
0.008382595,
-0.03713808,
-0.003677333,
-0.002022699,
-0.023821425,
0.012998328,
0.020359626,
-0.010577721,
-0.024550924,
-0.0027256699,
-0.013290127,
0.0020442524,
-0.008190273,
-0.010252763,
-0.022906236,
0.01790586,
0.017627325,
-0.004721842,
-0.0017856122,
-0.00078669726,
-0.011652073,
-0.029418664,
0.018343559,
0.021964522,
-0.02273381,
-0.034830213,
0.0050832746,
0.014868496,
-0.009463578,
-0.009204938,
0.031116406,
-0.021818621,
-0.007023076,
-0.0024438184,
0.011479646,
0.023317408,
-0.008037741,
-0.0110751055,
0.0077857333,
0.01304475,
0.012447889,
-0.013780881,
0.008442282,
0.043531135,
-0.017852806,
-0.020903433,
0.029206447,
0.011658704,
-0.0029743623,
0.023649,
0.030214481,
-0.018011969,
0.023264354,
0.0003434029,
0.018781258,
0.008429018,
0.006684854,
0.0029610987,
-0.022229794,
-0.0055972394,
0.027720924,
-0.017282471,
-0.029020756,
-0.011506173,
0.00602499,
0.011419959,
0.012560629,
0.003145131,
-0.005205963,
0.0035579607,
0.001290714,
0.0002870326,
-0.02729649,
0.0030323905,
0.026129292,
0.012189249,
-0.004376988,
-0.015982637,
-0.025877284,
0.01315086,
0.031408206,
0.016619291,
-0.0030042054,
0.01819766,
-0.0020309887,
0.029577827,
-0.012726424,
-0.023529626,
-0.011320483,
-0.0019381435,
-0.00418135,
-0.0067810155,
0.018011969,
-0.033609964,
0.08759281,
0.009039143,
-0.0013064645,
0.018144604,
-0.011864291,
0.007726047,
-0.0036209628,
0.0164336,
-0.043053646,
-0.0403744,
0.006499164,
-0.009821696,
-0.0023161562,
-0.020386154,
-0.014218579,
0.03175306,
-0.016340755,
0.018595567,
0.0020823851,
-0.0076199383,
0.007759206,
-0.030055318,
-0.0067080655,
0.00019574173,
-0.013402868,
0.000053468888,
0.0017839542,
0.019550547,
-0.007248557,
0.0017524532,
-0.01134701,
-0.004347145,
-0.055388793,
-0.002979336,
-0.0038729713,
-0.010345608,
-0.012308621,
-0.015213349,
-0.009894646,
0.015850002,
-0.012985065,
0.007991319,
-0.006134415,
-0.03448536,
-0.016592763,
0.030771552,
-0.017561005,
0.007420984,
-0.011154688
] |
Recent observations have suggested that classic antibiotics kill bacteria by stimulating the formation of reactive oxygen species (ROS). If true, this notion might guide new strategies to improve antibiotic efficacy. In this study, the model was directly tested. Contrary to the hypothesis, antibiotic treatment did not accelerate the formation of hydrogen peroxide in Escherichia coli and did not elevate intracellular free iron, an essential reactant for the production of lethal damage. Lethality persisted in the absence of oxygen, and DNA repair mutants were not hypersensitive, undermining the idea that toxicity arose from oxidative DNA lesions. We conclude that these antibiotic exposures did not produce ROS and | [
-0.003239775,
-0.019938108,
-0.025100295,
-0.037087295,
-0.009198078,
0.018476605,
-0.0008849463,
-0.010230515,
-0.011457372,
-0.008655043,
0.008996954,
0.014896596,
-0.0054337042,
0.024550555,
-0.012322207,
-0.00027256514,
0.053016327,
0.015593827,
0.011329995,
0.011081941,
-0.00899025,
0.011410444,
0.0013450178,
-0.005222524,
0.019576084,
0.0070862747,
0.021654367,
-0.03432519,
-0.008641635,
-0.004652672,
0.00426048,
0.0044750124,
-0.029390944,
-0.0062616654,
-0.029820008,
-0.008386877,
0.0179805,
0.0021453244,
0.0057756156,
0.0036470515,
0.017645292,
0.0040057227,
0.0015796627,
0.006533183,
0.0054605207,
0.003727501,
-0.0016575983,
0.00037564128,
0.0028777516,
-0.0037844863,
0.0278624,
-0.008239387,
-0.0009293612,
0.0021721409,
0.019187246,
-0.015272028,
0.016371507,
0.013864159,
-0.008936617,
-0.00002713081,
0.005276157,
0.0031408889,
-0.034459274,
0.009855084,
-0.03566602,
0.016720122,
0.020152641,
0.0221907,
0.006714195,
0.01898612,
0.040814795,
0.018490015,
0.014816146,
0.0025526008,
0.017779376,
-0.008413694,
-0.024952805,
-0.003192846,
0.024121491,
0.008024854,
0.002136944,
0.008266203,
-0.025636626,
0.018583871,
0.018422972,
-0.014842963,
-0.015540194,
0.022016391,
-0.010746734,
0.0010936126,
-0.0020430863,
0.024765087,
0.031160837,
0.030168625,
-0.00023401633,
0.031026753,
-0.010391415,
0.032823462,
-0.013106591,
-0.026213182,
-0.006627041,
-0.022673396,
-0.02133257,
-0.022512497,
-0.019468818,
0.009519877,
0.022123657,
-0.0047632903,
0.013187041,
-0.00059457327,
-0.009472948,
0.02522097,
-0.006037077,
-0.045024995,
0.017149186,
0.0108674085,
0.007682943,
0.0011832805,
-0.029820008,
-0.014682064,
0.018999528,
0.01704192,
0.016867613,
-0.015660867,
0.005668349,
-0.008775718,
-0.02864008,
-0.0034157587,
-0.00844051,
0.009010362,
-0.008755605,
0.014775922,
0.009660664,
-0.0064493814,
-0.003003454,
0.051809583,
-0.04395233,
-0.010290853,
-0.021761633,
-0.018168215,
0.018919079,
0.016639672,
-0.020595115,
0.012208236,
-0.008929913,
-0.0004215227,
0.038723104,
0.018195033,
0.01035119,
0.020796238,
0.014735697,
-0.021064404,
0.002269351,
-0.015285436,
0.0030235664,
0.01743076,
-0.016626263,
0.034620173,
-0.030490423,
-0.015902217,
0.017484393,
-0.016317874,
0.015875401,
-0.014775922,
0.01914702,
0.020688972,
0.01346191,
0.01634469,
0.019388368,
-0.015419519,
-0.012623893,
0.017336903,
-0.010840592,
0.022163883,
0.016626263,
0.03719456,
0.01082048,
0.021050995,
0.014628431,
-0.010284149,
0.0017598363,
0.017028512,
0.027446743,
-0.000582422,
0.006911967,
0.010639468,
0.013998241,
-0.019079978,
0.013227265,
-0.027621051,
-0.0046761367,
0.03051724,
-0.005178947,
-0.0064493814,
-0.63544506,
-0.028103748,
-0.0004307409,
-0.0045621665,
0.016626263,
0.013522248,
-0.0033503934,
-0.0062750736,
-0.031536266,
0.03837449,
-0.0054437607,
0.017658701,
0.01906657,
-0.0031626774,
0.0016835768,
-0.023075646,
0.010290853,
0.008065078,
0.010679693,
-0.008138824,
0.009077404,
-0.015513376,
-0.023236545,
-0.012530035,
0.007455002,
0.030597689,
0.011155686,
-0.0027486968,
0.0027369645,
0.0032012262,
-0.020112416,
0.029605476,
0.014923412,
0.00056440465,
0.05674383,
-0.0135088395,
0.011531118,
0.032528482,
0.017176002,
0.027272437,
0.009553397,
-0.008929913,
0.029632293,
-0.009761225,
-0.01775256,
0.014306632,
0.027031086,
0.0028190904,
-0.0075287474,
0.011457372,
0.019187246,
0.00055937655,
-0.0104919765,
0.005728686,
0.04301375,
0.017082145,
0.014212774,
-0.026280222,
0.001646704,
0.013314419,
-0.019683352,
0.0064259167,
-0.019133613,
-0.014252999,
-0.037033662,
0.035612386,
-0.03121447,
0.007877363,
0.012114379,
-0.022418639,
-0.0012419417,
0.014387081,
-0.0038045987,
0.0013047929,
-0.011296473,
0.024993028,
-0.009358978,
0.03571965,
-0.017403943,
0.009439427,
0.012194828,
-0.0071801324,
-0.017993908,
0.009030474,
0.028613264,
-0.0025224322,
-0.02311587,
-0.0042403676,
-0.012630597,
-0.042316522,
0.0025794173,
0.0322335,
-0.033359792,
-0.034834705,
-0.015164762,
0.014440714,
-0.017765967,
0.003290056,
0.013602697,
-0.019053161,
-0.033815674,
-0.006345467,
0.03362796,
0.029766375,
-0.0016207255,
0.0028308225,
-0.027916033,
-0.023839917,
0.029980907,
-0.019817434,
0.003767726,
0.015070904,
0.010518793,
-0.0005694328,
0.011544527,
-0.022458864,
0.025636626,
0.01564746,
-0.011021604,
-0.038857188,
0.0021067755,
-0.019307919,
-0.0026330505,
-0.034968786,
0.01602289,
-0.008279611,
0.0043275217,
-0.014950229,
-0.009969054,
-0.014628431,
0.0038045987,
0.011028308,
0.023960592,
-0.014092099,
-0.00072823704,
0.012711047,
0.02303542,
-0.016411731,
0.028532814,
-0.022700213,
-0.0366046,
-0.0005853551,
-0.016639672,
0.0011681962,
-0.018972712,
-0.02172141,
-0.033091627,
-0.0009813183,
-0.010592539,
0.0021453244,
0.024322614,
0.0020162696,
-0.018959304,
0.01945541,
0.00821257,
-0.015593827,
-0.016358098,
-0.028505998,
-0.010056208,
0.010002575,
0.0028760755,
0.01556701,
0.010552314,
0.012033929,
-0.035210136,
-0.014333448,
0.014668656,
0.016210606,
0.010029391,
-0.023732651,
-0.0029883697,
-0.032260314,
0.0012662442,
0.013562473,
-0.011423852,
0.01525862,
-0.04169974,
0.013388164,
0.0024956155,
0.002762105,
0.026977453,
-0.011692017,
-0.0033671537,
0.010518793,
0.010015983,
0.0024034337,
0.018959304,
-0.0009813183,
-0.007837138,
0.043174654,
-0.0034207867,
0.016599447,
0.010914338,
-0.0033738578,
-0.009245007,
-0.028479181,
0.0044783647,
-0.0030738476,
0.014145733,
0.031777617,
0.012087562,
-0.009855084,
0.021775043,
-0.028961878,
0.021909125,
0.019026345,
-0.019334735,
-0.02249909,
0.023799691,
0.018892262,
-0.00064527337,
-0.007977925,
-0.021761633,
-0.015768133,
-0.000483955,
0.0015846908,
0.0056348285,
0.012054041,
0.007113091,
-0.018020725,
-0.011249545,
-0.007542156,
-0.00060337246,
0.0102774445,
-0.017926866,
-0.0050113434,
0.029015511,
-0.008266203,
-0.01812799,
0.0030302706,
-0.006526479,
0.015526785,
0.020983953,
-0.013797117,
0.021976165,
0.02530142,
-0.016089933,
0.00035112925,
0.01697488,
-0.0035900662,
-0.017484393,
-0.017698927,
0.004407971,
0.020997362,
0.021600734,
0.020742605,
0.048537962,
0.019830842,
-0.020434214,
0.006238201,
-0.027191985,
-0.0014966989,
-0.026776329,
-0.01190655,
-0.008004742,
-0.0033068163,
0.003874992,
0.008588001,
0.03665823,
0.015164762,
0.021077812,
-0.00034086354,
0.026561797,
0.0000385488,
-0.0110149,
0.024604188,
-0.0054839854,
-0.0017765968,
-0.009231599,
0.017538026,
-0.035826918,
-0.023987409,
0.018704547,
-0.004981175,
0.014802738,
0.0012343995,
0.0033118445,
0.031589903,
0.01867773,
-0.015607235,
-0.013890975,
-0.008903096,
0.02909596,
0.02078283,
0.0024972917,
-0.02319632,
-0.026709288,
-0.00685163,
-0.0060806535,
0.02272703,
0.019723576,
0.034781072,
-0.003340337,
0.017578252,
-0.002173817,
-0.021144854,
0.008507552,
-0.03679231,
0.011195911,
0.000919305,
-0.018945895,
-0.014588206,
-0.022297965,
-0.01688102,
0.026186366,
-0.015593827,
-0.0014749105,
-0.013629514,
0.0026514868,
-0.024081266,
0.01210097,
0.02606569,
-0.009117628,
0.0070728664,
-0.013783709,
0.012892058,
-0.01953586,
-0.008842759,
0.0050180475,
-0.011001492,
-0.025381869,
-0.031482633,
0.010592539,
-0.025194153,
0.023866734,
-0.008138824,
-0.006573408,
0.0277015,
0.023370627,
0.009251711,
0.012677526,
-0.03145582,
0.0039018088,
-0.030544056,
-0.003139213,
0.018610688,
0.03773089,
-0.004350986,
-0.0009930505,
0.0027269083,
0.00212186,
-0.030946303,
-0.01743076,
-0.012597077,
-0.00821257,
-0.014655247,
0.01712237,
0.037006844,
0.04054663,
-0.008695268,
0.0047230655,
0.0110149,
0.016009483,
-0.005996852,
-0.0069454876,
0.024268981,
0.001692795,
0.007106387,
0.004092877,
-0.02148006,
-0.0064929584,
0.0051085535,
0.02209684,
-0.006784588,
0.013602697,
0.0010374654,
0.01240936,
0.014038466,
-0.012825017,
-0.014896596,
0.011913254,
0.01276468,
-0.024899172,
-0.02475168,
-0.0021620847,
-0.0068415734,
-0.020970546,
-0.01869114,
0.0048437403,
-0.013254082,
-0.009546693,
-0.0007202759,
-0.007924292,
0.015929034,
-0.013522248,
-0.0117590595,
0.04263832,
-0.012429473,
-0.024765087,
-0.0048102196,
-0.0068449257,
-0.005132018,
-0.02094373,
0.012302094,
-0.009245007,
0.0008070107,
-0.026092507,
0.011102053,
0.02475168,
0.003429167,
0.007495227,
-0.03035634,
0.009982462,
0.011457372,
-0.015513376,
0.0033570975,
0.01159816,
-0.040037114,
0.020997362,
0.026320448,
-0.007904179,
-0.009426019,
-0.021131445,
0.014306632,
0.02125212,
-0.010284149,
0.009828268,
-0.005802432,
0.007830434,
-0.0031073682,
-0.0025274602,
0.03317208,
-0.013160224,
-0.014226182,
-0.020407397,
-0.030383157,
-0.010927746,
-0.019173836,
-0.023182912,
-0.026320448,
-0.0179805,
0.0076091974,
-0.00976793,
0.010364599,
0.022794072,
-0.009063995,
-0.0077902093,
-0.02178845,
-0.0002998007,
0.005812488,
-0.014145733,
0.039956667,
-0.0068114046,
0.013971425,
-0.030624505,
-0.0027252324,
0.0050113434,
0.002472151,
-0.0077097593,
-0.00106093,
-0.008815942,
-0.045775857,
-0.041512027,
-0.0072873984,
-0.006529831,
0.016746938,
0.003338661,
-0.024858946,
-0.019696759,
-0.002128564,
-0.0016341337,
0.016224016,
-0.00080072554,
-0.029685926,
-0.0073745525,
-0.0006088196,
-0.0042906487,
-0.0320726,
0.036631413,
-0.028935062,
-0.014132325,
0.018101174,
-0.0044247317,
-0.0051521305,
0.0052024117,
-0.024161715,
-0.018141398,
0.027486969,
-0.025073478,
-0.033359792,
0.015929034,
-0.017605068,
0.0260791,
0.034995604,
0.033896126,
-0.011685314,
0.0071332036,
0.03432519,
0.009861788,
0.010317669,
-0.024429882,
0.01440049,
-0.012308799,
-0.0018302299,
-0.026870187,
-0.009157853,
-0.0014723964,
-0.008701972,
-0.0020548184,
0.011443964,
-0.0048035155,
-0.007501931,
-0.0322335,
-0.029846825,
-0.021386202,
-0.002178845,
-0.011692017,
-0.004920838,
-0.039956667,
-0.006777884,
0.033681594,
0.0040425956,
0.001402003,
-0.00667397,
0.015620643,
0.0030269185,
0.023544936,
-0.01194007,
0.013247378,
-0.0055409707,
-0.012221645,
0.011913254,
-0.0070795706,
0.013730076,
-0.0034928562,
-0.0124026565,
0.020662155,
-0.0057856715,
-0.0049409503,
0.0019458763,
-0.006144343,
-0.027486969,
-0.006737659,
-0.01634469,
0.008306428,
0.010451752,
0.030570872,
-0.011262953,
-0.023611976,
0.010726621,
-0.004176678,
0.016224016,
-0.02211025,
-0.008882984,
0.036711864,
-0.010371302,
0.018999528,
-0.030678138,
0.012737864,
0.0042839446,
0.008762309,
-0.000091343885,
0.01046516,
-0.008849463,
-0.008132121,
0.012362432,
0.0017665406,
-0.019482227,
-0.013260786,
0.0013374756,
0.007535452,
-0.017484393,
-0.013321123,
0.028479181,
0.00084555947,
0.0052191718,
-0.024778496,
-0.019039754,
-0.029712742,
-0.009620439,
-0.008541073,
-0.024161715,
0.010210403,
0.0046157995,
-0.018355932,
-0.002894512,
0.018878855,
0.014802738,
-0.00018195451,
-0.009211486,
-0.020581705,
-0.034834705,
0.002177169,
0.019267695,
-0.0049074297,
0.016250832,
-0.015070904,
0.025824342,
0.013522248,
0.019549267,
0.010445048,
-0.0028861316,
0.010699805,
0.03743591,
-0.013502135,
-0.0082058655,
0.009566806,
0.013294307,
0.011665201,
-0.027151762,
0.0011489218,
-0.022123657,
-0.02530142,
0.010083024,
0.029364128,
0.020635339,
0.011068533,
-0.008279611,
-0.024724863,
-0.0020129175,
0.007642718,
-0.025877975,
-0.0012871947,
-0.015392702,
-0.0036839242,
0.0054471125,
0.0068348693,
0.0042336634,
-0.020554889,
0.0018419621,
-0.007408073,
-0.011926662,
-0.020916913,
0.009714297,
0.012020521,
-0.0053499024,
-0.015593827,
0.003150945,
-0.0026715992,
-0.013683147,
0.007059458,
-0.018463198,
-0.024376247,
-0.038803555,
-0.031321734,
-0.003241451,
0.022137066,
-0.016988287,
0.015231803,
0.004334226,
0.011665201,
-0.011779171,
-0.03424474,
0.025837751,
-0.0029850176,
0.023611976,
0.012972509,
-0.016639672,
0.0033219007,
-0.0042336634,
0.011966888,
0.0050549204,
0.0063287066,
-0.020219682,
-0.015044087,
0.009278527,
0.0010450076,
-0.0086349305,
0.014896596,
0.009627143,
-0.018034132,
-0.00053088396,
0.022928154,
0.012496514,
-0.007394665,
-0.01953586,
-0.002614614,
-0.006218089,
0.0023280121,
0.0102774445,
0.013904383,
0.010585835,
-0.026789738,
-0.008360061,
0.019428594,
0.030624505,
0.008963433,
-0.021962758,
-0.002663219,
-0.017243044,
-0.024014225,
-0.0040794685,
-0.027755134,
-0.00848744,
0.019790618,
0.0033520693,
0.0013366377,
0.0051420745,
-0.0043778024,
0.019428594,
-0.008306428,
-0.013535656,
0.0032531833,
-0.001934144,
0.013106591,
-0.015044087,
-0.026897004,
0.0005577005,
0.03089267,
0.00064359733,
-0.002909596,
0.020769421,
0.02265999,
0.0076695345,
0.0042705364,
0.0015168113,
0.028881429,
0.014641839,
0.010847297,
-0.035344217,
-0.016787164,
0.029632293,
-0.011946775,
0.0003293408,
0.002906244,
0.013823934,
0.010619355,
0.0031861418,
0.009607031,
-0.029310495,
0.011618272,
-0.010988083,
0.022083433,
0.014373673,
0.015245211,
-0.0005019724,
-0.0049945833,
-0.038803555,
-0.019388368,
-0.013160224,
-0.0048672045,
0.003142565,
0.010746734,
-0.0025794173,
-0.020957137,
-0.014185958,
0.005514154,
-0.015526785,
0.009928829,
0.004404619,
-0.0014723964,
-0.013837342,
0.02653498,
0.003095636,
0.012972509,
0.00092098105,
0.014387081,
-0.021050995,
-0.0070460495,
-0.01642514,
0.0039889626,
-0.010565722,
0.0073812567,
-0.016237423,
-0.005990148,
-0.0034425752,
-0.005209116,
-0.0047901073,
-0.013823934,
0.02031354,
0.19930063,
-0.0057689114,
-0.002423546,
0.0076762387,
-0.0051923553,
-0.015499968,
-0.01151771,
-0.020621931,
0.0019224117,
0.022083433,
0.03268938,
0.0010022687,
0.0020950434,
0.0006394072,
0.020367173,
0.008782421,
-0.000023150229,
0.0025274602,
-0.01859728,
-0.012194828,
0.009969054,
0.00144977,
0.003135861,
0.0026514868,
0.022244332,
0.010250628,
-0.025033254,
-0.0074214814,
0.021278936,
-0.012147899,
-0.011021604,
-0.00003983201,
0.021359386,
0.009814859,
0.014051874,
-0.019053161,
-0.00949306,
0.0027688092,
0.02086328,
-0.015821768,
0.01642514,
0.032340765,
-0.012033929,
-0.0014338476,
0.0024486866,
0.010639468,
-0.014936821,
-0.010243923,
-0.013059662,
-0.0012427797,
-0.031884883,
-0.015499968,
-0.0025458967,
0.0006586816,
0.008849463,
-0.00980145,
0.020715788,
0.0031040162,
-0.015003862,
0.0067644757,
-0.01859728,
0.0069656,
-0.028184198,
-0.0019173836,
-0.030731771,
0.021694593,
-0.042396974,
0.014923412,
-0.019187246,
0.01665308,
0.015432927,
-0.012496514,
-0.018409565,
-0.0101165455,
-0.013823934,
-0.01190655,
-0.0015402759,
0.017457576,
0.032903913,
0.018422972,
0.02047444,
-0.0060773017,
-0.029310495,
0.016800571,
-0.03129492,
-0.014159141,
0.008386877,
0.020823054,
-0.029471394,
0.021292344,
-0.006777884,
-0.006911967,
-0.0009461216,
0.004448196,
0.0032665916,
-0.02164096,
-0.017712334,
0.0082594985,
-0.012737864,
0.005078385,
-0.038776737,
0.06055178,
-0.031241287,
-0.012536739,
-0.004997935,
0.018865446,
-0.0057689114,
0.018999528,
-0.021909125,
0.008769013,
0.0069454876,
-0.008172345,
-0.015432927,
-0.013354644,
0.005708574,
0.029739559,
0.014869779,
-0.016170382,
0.019576084,
-0.02342426,
0.00049568724,
-0.022941561,
-0.0139312,
0.019254286,
-0.0059599793,
-0.008614819,
-0.031429,
0.009419315,
-0.0022458865,
-0.035076052,
-0.0018218496,
0.007394665,
-0.0012729483,
0.025569584,
0.00829302,
0.02249909,
-0.0052024117,
-0.019817434,
-0.011819396,
0.0014564741,
-0.010666285,
0.017725743,
0.0047096573,
0.013636218,
-0.0045789266,
-0.03620235,
0.029283678,
-0.0033302808,
-0.0020648746,
-0.0037576696,
-0.01109535,
-0.0073142154,
-0.012449586,
-0.000014953372,
-0.00032682676,
-0.027259028,
-0.01602289,
-0.03424474,
0.009834971,
0.01906657,
-0.02031354,
0.0033688296,
0.018557055,
-0.017015103,
-0.0155804185,
-0.0023648848,
-0.16840796,
0.019884475,
0.014480939,
-0.005272805,
0.04590994,
0.0010047827,
0.030839037,
0.012308799,
0.012811609,
0.007998037,
0.00918467,
0.007984629,
-0.03767726,
-0.019683352,
0.016210606,
0.025569584,
0.0019844251,
0.03145582,
0.04132431,
0.003573306,
0.016398324,
-0.021144854,
0.025368461,
-0.021748226,
0.002220746,
0.018248666,
-0.0011866326,
0.021292344,
-0.00077600405,
-0.017806193,
-0.021386202,
0.0017196116,
0.006767828,
-0.0070393453,
-0.0035230247,
-0.0037643737,
0.009761225,
0.006278426,
-0.007461706,
0.012804905,
0.029712742,
0.015969258,
0.0006423403,
-0.013890975,
-0.01548656,
0.048055265,
0.017993908,
0.0019274398,
0.032313947,
-0.01334794,
0.014910004,
-0.0052795094,
0.0065700556,
0.015996074,
-0.014346857,
-0.00541024,
-0.029551843,
0.0086885635,
-0.007542156,
-0.010264036,
0.004582279,
-0.05089782,
0.027031086,
-0.000872376,
-0.018168215,
-0.010766847,
-0.011987,
-0.007930996,
-0.022405231,
0.015245211,
-0.02872053,
-0.0048806127,
0.015513376,
0.010894225,
0.0076159015,
-0.0030285947,
-0.0044716606,
0.0071399077,
0.008225978,
0.018999528,
0.005071681,
0.00037941235,
-0.033896126,
0.0034459273,
0.0007018395,
0.014199366,
0.011443964,
0.03681913,
-0.018798405,
-0.0015226775,
0.027486969,
-0.021158261,
-0.005842657,
0.0018620745,
0.01540611,
0.02528801,
0.0004062289,
0.019817434,
-0.008655043,
-0.011423852,
0.019348145,
-0.0034593355,
-0.00976793,
0.013414982,
0.009915421,
0.00005724706,
-0.010840592,
-0.022995196,
0.06865038,
-0.01240936,
-0.009754522,
0.0023430965,
0.002809034,
0.03488834,
-0.023491303,
0.02794285,
0.006385692,
-0.009513172,
-0.015996074,
-0.006295186,
0.048082083,
0.004495125,
-0.01124284,
0.0059867958,
-0.016746938,
-0.058728255,
-0.14030421,
-0.042584687,
-0.017806193,
0.01303955,
-0.0012260193,
0.010096433,
0.0063152984,
0.0011212672,
-0.0028408787,
0.022592947,
0.018087765,
-0.0037375572,
-0.003767726,
-0.018275483,
0.009814859,
-0.000101400095,
0.014145733,
-0.0013341235,
-0.031589903,
0.032394398,
-0.002079959,
-0.0064996625,
0.0055409707,
-0.00011669391,
0.011309882,
-0.0040727644,
-0.016948063,
0.02630704,
-0.017538026,
-0.0035431373,
0.040198017,
0.00039889626,
-0.0085276645,
-0.012630597,
-0.0050984975,
0.007837138,
0.014762513,
-0.0014397138,
0.035210136,
-0.024376247,
0.0067410115,
0.023839917,
0.022767255,
0.02131916,
0.01812799,
-0.013314419,
0.009620439,
-0.0046023913,
-0.0030168623,
-0.016760347,
-0.027969666,
0.009305344,
-0.03869629,
0.012188124,
0.016465364,
-0.0139312,
0.01922747,
0.038884003,
-0.011135574,
-0.022432048,
0.0022777312,
-0.007059458,
-0.034673806,
0.004967767,
-0.0054236483,
-0.033735227,
-0.014936821,
-0.028479181,
0.009426019,
-0.04818935,
0.013716668,
-0.0020967193,
-0.005467225,
0.02599865,
-0.021909125,
-0.0044347877,
-0.0010827184,
-0.011256249,
0.005862769,
0.005601308,
-0.011638384,
-0.0012033929,
0.0108674085,
-0.019039754,
0.023397444,
0.009265119,
-0.015942441,
0.016224016,
-0.0077097593,
-0.015768133,
-0.034271557,
0.027138352,
-0.0056247725,
-0.0069387835,
0.0067510675,
0.026508164,
-0.0057722633,
-0.03089267,
0.017886642,
0.0025509247,
-0.0319117,
-0.020192865,
-0.029015511,
0.023746058,
-0.01237584,
-0.027889216,
0.00062138983,
0.021748226,
-0.011470781,
0.009948942,
0.008339948,
0.00026355646,
-0.019696759,
0.008199162,
-0.0073276237,
-0.021909125,
-0.02661543,
-0.037328646,
0.0057756156,
-0.0058359527,
0.03298436,
-0.008118711,
-0.0076091974,
0.0035967703,
0.01132329,
0.022619763,
-0.009003658,
0.0032749716,
-0.009271824,
0.018865446,
-0.0000040264113,
-0.027460152,
0.011008196,
-0.028211016,
-0.008534368,
-0.012576964,
-0.017672108,
-0.020756014,
-0.027379703,
0.038562205,
-0.0039956667,
0.013475318,
-0.017564842,
-0.033198893,
0.007267286,
-0.02156051,
-0.005457169,
-0.008608114,
-0.021989575,
0.038320858,
-0.0071734283,
-0.004203495,
0.01867773,
0.015365886,
-0.029927274,
-0.041619293,
-0.013636218,
-0.015392702,
0.00004145567,
-0.007964517,
-0.014159141,
0.00019431527,
0.024322614,
0.02622659,
-0.0011262953,
0.008225978,
0.013582584,
-0.015030678,
-0.0018570464,
-0.026762921,
0.00019232498,
-0.031884883,
-0.040868428,
-0.008923208,
0.0070728664,
-0.008031558,
0.022432048,
-0.017658701,
0.0010676341,
-0.00328838,
0.010485273,
0.026508164,
-0.004387859,
-0.01812799,
-0.01284513,
0.01744417,
0.03429837,
-0.0042403676,
0.008071783,
0.015888808,
0.005983444,
-0.015204987,
0.0057923757,
0.016156973,
0.0011992028,
-0.0015629024,
0.004176678,
0.015325661,
-0.015620643,
0.0013341235,
-0.00086399587,
0.0074348897,
0.015888808,
-0.007924292,
-0.013468615,
-0.0060236687,
-0.0017062033,
0.014387081,
-0.018235257,
-0.02295497,
-0.022445455,
0.028398732,
0.0043308735,
0.015701093,
0.0063052424,
-0.000060389622,
-0.0012385896,
0.023022013,
-0.021935942,
-0.016438548,
0.012436178,
0.02046103,
0.03183125,
0.005376719,
-0.0029783135,
0.006218089,
0.03542467,
-0.000007411216,
0.04054663,
-0.018275483,
0.0364437,
-0.014239591,
0.044113234,
-0.0062449053,
-0.052479997,
-0.020487847,
0.018342523,
-0.013917792,
0.023732651,
0.011142278,
-0.013448502,
0.0720829,
-0.008145529,
-0.015151354,
0.028050115,
0.0009788042,
0.016827388,
0.0031073682,
0.009446131,
0.019012937,
-0.05097827,
0.045266345,
0.012134491,
0.04247742,
-0.01812799,
-0.030302707,
0.014226182,
-0.011162391,
0.007253878,
0.004575575,
-0.020528072,
0.035397854,
-0.0035666018,
0.00093774137,
0.008192457,
-0.035692833,
-0.008185754,
0.024684638,
0.0019609604,
0.016518997,
-0.04054663,
-0.01240936,
0.00025119568,
-0.01015677,
-0.009533285,
0.01945541,
0.0053431983,
-0.017538026,
-0.011336698,
0.013730076,
-0.010009279,
-0.024322614,
0.012174715,
-0.0058158403,
-0.055671167,
-0.028157381,
0.007052754,
-0.0005882882,
-0.006238201,
-0.00017640265
] |
Pioneer transcription factors (TFs) access silent chromatin and initiate cell-fate changes, using diverse types of DNA binding domains (DBDs). FoxA, the paradigm pioneer TF, has a winged helix DBD that resembles linker histone and thereby binds its target sites on nucleosomes and in compacted chromatin. Herein, we compare the nucleosome and chromatin targeting activities of Oct4 (POU DBD), Sox2 (HMG box DBD), Klf4 (zinc finger DBD), and c-Myc (bHLH DBD), which together reprogram somatic cells to plur | [
-0.033074114,
-0.02188021,
-0.020063538,
-0.0050392607,
-0.034516767,
0.020330695,
-0.019943317,
0.0049657924,
-0.016804215,
-0.017004583,
0.0017615706,
0.025446763,
0.009684464,
0.0055435207,
-0.0033027362,
0.013671791,
0.0063383146,
-0.016817572,
-0.0052964,
0.0014526696,
-0.026301669,
0.00819506,
-0.014600164,
-0.01903498,
-0.005717173,
0.011167189,
-0.0059609544,
-0.040955264,
-0.031978767,
-0.010345679,
0.017191593,
0.02672912,
-0.0052630054,
0.020905085,
-0.020905085,
0.0044348165,
-0.006204736,
-0.013110761,
0.020758148,
0.013170871,
0.023122493,
0.025379974,
-0.011654751,
0.0031925335,
-0.018620886,
-0.0041543012,
0.0031875244,
-0.00863587,
-0.0020571137,
0.014052491,
0.004381385,
0.015481784,
-0.0096777845,
0.006511967,
-0.0008624182,
-0.018647602,
0.036360152,
0.018180076,
0.007894508,
-0.011507815,
-0.0201704,
0.0021172243,
-0.008776128,
0.014813891,
-0.014172712,
0.02566049,
0.0016213128,
0.021038663,
0.0029938351,
0.010793168,
0.034249607,
0.030295674,
-0.0018367086,
-0.008281887,
0.013484781,
-0.017645761,
-0.046378564,
0.0049223793,
-0.012629877,
0.009590959,
0.01292375,
-0.011774972,
-0.0106462315,
0.035772406,
0.016911078,
0.002452841,
0.00024670336,
0.013484781,
0.000042578245,
0.0063650305,
0.017124804,
0.039111875,
0.041222423,
0.02288205,
-0.0032960572,
0.008756091,
0.02188021,
0.019676158,
0.004231109,
-0.021933641,
-0.011641393,
0.010005053,
-0.013478102,
-0.011193904,
-0.029601065,
0.020597853,
0.014159354,
-0.0063416543,
0.0052596657,
-0.01235604,
-0.020023463,
0.028291993,
0.0050092055,
-0.060163897,
0.03662731,
-0.03435647,
-0.016283257,
0.0012523014,
-0.0034262966,
-0.000011133742,
0.033127546,
0.040634673,
-0.0060644783,
-0.03208563,
-0.0041142274,
0.007794324,
-0.014039133,
0.0058206967,
-0.0007747571,
0.009036607,
0.027624099,
0.015708867,
0.0049524345,
0.0135515705,
-0.025794068,
0.0016313313,
-0.015481784,
0.00624147,
-0.018206792,
-0.032646663,
0.0046051294,
0.026488679,
-0.008722696,
-0.011153831,
0.022654967,
0.010526011,
0.009357195,
-0.009838079,
0.025219679,
0.010005053,
0.025259754,
0.0058607706,
0.031310875,
0.0060511203,
0.012943787,
0.026234878,
0.0031925335,
0.030803274,
0.0063950857,
-0.009998374,
-0.018380444,
0.003977309,
0.00485225,
0.020958515,
0.026461963,
0.020851653,
0.0013599993,
0.011694825,
0.00084697315,
-0.015789015,
0.010252174,
-0.0076741027,
-0.051614854,
0.01204213,
-0.011026931,
-0.005616989,
-0.009403949,
0.0204242,
-0.03555868,
-0.012075525,
-0.005870789,
-0.002118894,
0.008716018,
0.004865608,
-0.02596772,
-0.012710024,
0.0036166464,
-0.03454348,
-0.008816201,
-0.006398425,
0.0042277696,
0.008756091,
0.021506188,
0.0026097961,
-0.6202331,
0.010098558,
0.015187911,
-0.042023893,
0.004444835,
0.028585866,
-0.01657713,
-0.002591429,
-0.014640238,
0.008188381,
-0.012209103,
0.002426125,
0.021532904,
-0.030108664,
-0.033207692,
-0.052443042,
0.0003754817,
-0.014813891,
0.021572977,
0.018834613,
0.0035565358,
-0.0036901147,
-0.021385968,
0.017952992,
0.0049290583,
-0.0050459397,
0.007814361,
-0.005877468,
0.0086959805,
0.019596012,
-0.022654967,
0.012249177,
-0.008462218,
0.0065954537,
0.04896999,
0.012128957,
0.006475233,
0.033314556,
0.0354251,
0.03742878,
-0.018607529,
-0.0019268744,
0.024351418,
0.010038448,
-0.01582909,
0.01696451,
-0.006418462,
0.013651755,
0.0035966095,
0.0014985873,
0.010566084,
0.0070329243,
-0.023883892,
-0.0012431178,
-0.0054900893,
0.023763672,
0.030803274,
-0.012589803,
0.009557564,
-0.008929743,
-0.007914545,
0.011621357,
-0.023483155,
-0.018113287,
-0.0063383146,
-0.007206577,
-0.0024161069,
0.011040289,
0.020477632,
-0.018901402,
0.013197587,
0.019929959,
-0.0052362895,
-0.005383226,
0.007647387,
0.037161626,
0.014145996,
-0.002180674,
-0.013524855,
0.047367048,
0.0063115987,
-0.013204265,
-0.021265747,
-0.00699953,
0.03772266,
0.004621827,
-0.0123627195,
0.03430304,
-0.01216903,
-0.026194805,
-0.0049457555,
0.0031290837,
-0.0071731824,
-0.022534745,
-0.031684894,
0.01910177,
0.0014768807,
-0.012536371,
0.0012781823,
-0.024818944,
-0.016750783,
-0.00084697315,
0.003352828,
-0.0019435717,
0.021679841,
-0.0033311215,
-0.02957435,
0.009123432,
0.038550846,
-0.024177765,
-0.0121957455,
-0.017819414,
-0.0027066406,
-0.0066355276,
0.014613522,
-0.02313585,
0.019502506,
0.006498609,
-0.024698723,
0.004635185,
0.030108664,
-0.01443987,
-0.017832771,
-0.006979493,
0.0066488856,
0.022467956,
0.0009676115,
-0.021092094,
-0.009210259,
0.0065653985,
0.006992851,
-0.010572763,
0.025005953,
-0.022334378,
-0.005687118,
0.0102121,
0.025807427,
-0.0014593485,
0.029040033,
-0.01884797,
-0.038256973,
-0.010318963,
0.0017248364,
0.0021957017,
-0.008963138,
-0.033047397,
-0.007947939,
0.008428823,
0.006986172,
-0.008001371,
0.026181446,
0.00054809055,
-0.03467706,
-0.0018500666,
0.0135515705,
-0.015842447,
-0.0064151227,
-0.031871904,
-0.0018817915,
-0.01972959,
-0.002534658,
0.009170186,
-0.002427795,
-0.0028602562,
-0.0049925083,
-0.022387808,
0.0014359723,
0.008395429,
0.00017333939,
-0.03991335,
0.017819414,
-0.012135635,
-0.016777499,
0.006511967,
-0.006141286,
0.000671651,
-0.0035698938,
0.009130112,
-0.004004025,
-0.007293403,
-0.022107294,
-0.014693669,
-0.0076340293,
-0.013190907,
0.023282787,
-0.006157983,
0.0039071804,
0.021025306,
-0.014039133,
0.007894508,
0.0074670557,
-0.003953933,
-0.004949095,
0.011060325,
0.0055835946,
-0.004568395,
0.023590019,
0.015935952,
-0.01588252,
0.02320264,
0.013144155,
-0.018888043,
0.005920881,
-0.027624099,
0.003493086,
-0.012583124,
-0.017939635,
-0.025794068,
-0.010933426,
0.00092085893,
0.00095091417,
-0.008094876,
0.009317122,
-0.01222914,
0.0016171385,
0.010405789,
-0.0071598245,
0.009003212,
-0.0065954537,
-0.01713816,
0.0054233,
-0.00052346196,
0.012810208,
0.008221776,
0.014145996,
-0.011941946,
0.004885645,
0.0019552598,
0.025019312,
-0.003543178,
-0.011501135,
0.008642549,
-0.012336004,
-0.0034196177,
0.02383046,
-0.011587962,
0.023149207,
0.0017073042,
0.031978767,
-0.022067219,
0.0035665543,
0.016857646,
-0.0045416798,
-0.0007100549,
-0.004772103,
0.000036160203,
0.023122493,
0.009537527,
-0.015775658,
-0.0014468255,
-0.014934111,
-0.023362935,
-0.012062167,
-0.0036300041,
0.008682623,
-0.009003212,
0.0023376292,
0.004317935,
0.020157043,
0.01972959,
0.024364775,
-0.012589803,
-0.012309288,
-0.023376292,
0.00040595437,
0.008829559,
-0.010612837,
-0.003473049,
-0.01866096,
-0.013084045,
-0.017164877,
0.020090254,
0.031551316,
-0.028398855,
0.016163036,
0.01399906,
-0.0068258774,
0.03700133,
0.013077366,
0.01228925,
-0.0031808454,
-0.036680743,
0.028104981,
0.028959887,
-0.00535985,
-0.0034763885,
-0.03176504,
-0.0066488856,
-0.017699193,
0.017098088,
0.0038170146,
-0.008549044,
-0.0023676844,
0.006992851,
-0.0012431178,
-0.0009809694,
0.021572977,
-0.017912919,
0.006952777,
-0.011087041,
-0.000137127,
-0.02098523,
0.0009091708,
-0.0016254871,
0.057011437,
0.00083611987,
0.004047438,
0.00019275006,
-0.004545019,
-0.028398855,
-0.013905554,
-0.0010627864,
-0.0077208555,
-0.010045127,
-0.027624099,
-0.010125274,
-0.0027033011,
0.0073935874,
0.018607529,
0.011895193,
-0.0300018,
-0.012730061,
0.002003682,
0.020370768,
0.03884472,
0.032192495,
-0.010145311,
0.0046752584,
-0.019048339,
0.008936423,
-0.02640853,
-0.012075525,
0.01488068,
-0.007520487,
-0.0044648717,
0.011594641,
-0.014466586,
-0.013865481,
0.011026931,
0.013611681,
-0.0042144116,
-0.041249137,
-0.027356941,
-0.014039133,
-0.02408426,
-0.012883676,
0.020811578,
0.026234878,
0.016096247,
-0.005369868,
-0.009604316,
0.044588607,
0.0017415337,
-0.012162351,
-0.008435502,
0.012689987,
0.02628831,
0.012502977,
0.018687677,
-0.037589077,
-0.0019819755,
0.017258383,
-0.014653596,
-0.004581753,
-0.0011170529,
0.020958515,
0.019088412,
-0.0039205384,
0.007821039,
-0.005075995,
0.011367557,
-0.004027401,
-0.027570667,
-0.018460592,
0.015548574,
-0.025313186,
-0.011587962,
-0.023523228,
0.008622512,
-0.020905085,
0.017218309,
-0.008989854,
0.008555723,
-0.029841507,
-0.018327013,
-0.015094406,
0.02326943,
-0.01708473,
0.025219679,
-0.027597383,
-0.010586121,
0.001664726,
-0.012636555,
-0.002175665,
-0.00028343755,
-0.016109604,
-0.045710668,
-0.00029575184,
0.046298414,
0.042291053,
0.021639768,
-0.021198958,
-0.0071397875,
0.023042345,
-0.0071130716,
-0.017231667,
0.0039005014,
-0.027837824,
-0.003145781,
-0.0076874606,
0.009524169,
-0.011955304,
-0.0054066023,
0.016550414,
-0.00035043567,
0.0010360706,
0.021052022,
-0.011708183,
-0.016871003,
0.024979237,
0.026568826,
0.039859917,
0.005426639,
0.0004595946,
-0.007647387,
-0.016109604,
-0.016470268,
-0.015789015,
-0.0077208555,
-0.0038671065,
0.014025776,
0.0040708142,
-0.01752554,
-0.011073683,
0.0057739443,
-0.022361092,
-0.0002915775,
0.008362033,
0.039886635,
0.026208162,
-0.013958986,
0.037615795,
-0.011875156,
-0.008442181,
-0.00009120928,
-0.028986603,
0.029280476,
0.0014209446,
-0.015201269,
0.011294088,
0.013471424,
-0.028906455,
-0.0149073955,
0.007306761,
-0.0024745476,
0.034436617,
-0.0057973205,
-0.020704716,
0.0034329754,
0.00699953,
-0.0027500538,
0.013838765,
0.00035607102,
-0.009951621,
-0.013317808,
0.019649444,
0.009029928,
-0.0148940375,
0.0011304107,
-0.031364307,
-0.018888043,
0.02837214,
0.012162351,
0.015535216,
-0.011621357,
-0.0061947173,
-0.013377918,
-0.023162566,
-0.014319649,
-0.03625329,
-0.005303079,
-0.02250803,
0.059683014,
0.02325607,
0.033127546,
0.015561932,
0.0055635576,
0.022721756,
0.01292375,
-0.0022140688,
-0.010345679,
0.01664392,
-0.024191123,
0.005389905,
-0.014333007,
-0.006518646,
0.017752625,
-0.016630562,
0.015321489,
0.03427632,
-0.025112817,
-0.026902772,
0.014960827,
-0.031097148,
-0.017645761,
-0.013351202,
-0.01557529,
-0.008602476,
-0.04696631,
0.010185384,
0.026021153,
0.0020788203,
0.0081282705,
-0.010639552,
0.031551316,
0.008148308,
0.034383185,
0.0017031298,
-0.001948581,
-0.01569551,
-0.0040507773,
-0.004802158,
0.0019151862,
0.03574569,
-0.0013057329,
0.018046498,
0.010980179,
0.010445863,
0.004047438,
0.020504348,
-0.01740532,
-0.012442866,
-0.024217838,
-0.016523698,
-0.014025776,
-0.02818513,
-0.0052162525,
-0.041462865,
0.0037368673,
-0.0006858437,
-0.024284627,
0.018514024,
0.009009891,
-0.021319179,
0.04621827,
-0.008989854,
0.042344484,
0.008235134,
0.008675944,
0.026435247,
-0.0007442844,
-0.020784862,
-0.015495142,
-0.021158883,
0.011881836,
0.032673378,
0.022401167,
-0.023777029,
0.0028335406,
0.02232102,
0.00201871,
-0.0152680585,
-0.026194805,
-0.01216903,
-0.012623197,
-0.008061482,
0.0031441113,
0.011127115,
-0.006695638,
0.013037292,
-0.005426639,
0.015775658,
-0.01349146,
-0.018433876,
-0.018420517,
-0.005663742,
-0.010879994,
0.015561932,
0.0063817278,
-0.004010704,
0.014159354,
-0.014199427,
0.018193435,
0.019221991,
-0.022334378,
0.054687165,
-0.019929959,
0.013010576,
0.017044656,
0.022174083,
-0.024110975,
0.00072967424,
0.0108466,
0.040901832,
-0.006688959,
0.009951621,
0.00951749,
0.00844886,
0.00008066908,
0.0073601925,
0.00034793105,
-0.02049099,
-0.0092904065,
-0.018059855,
0.012262535,
-0.00069711445,
0.0021589675,
-0.0047620847,
-0.018206792,
0.0007154815,
-0.019689517,
-0.031310875,
0.030215528,
-0.053297944,
-0.0018500666,
0.011634715,
0.028158413,
0.026194805,
0.013197587,
0.0023626753,
0.0047487267,
0.03318098,
-0.023282787,
0.0052329497,
0.022401167,
-0.0018968191,
-0.026528751,
-0.0018083232,
-0.0059743123,
-0.03806996,
-0.01204213,
-0.01898155,
-0.010425827,
0.009250333,
0.013605002,
0.038043246,
0.025059385,
-0.027517235,
0.013317808,
0.0106328735,
0.017806055,
0.011634715,
-0.010178706,
-0.01713816,
-0.02383046,
0.010332321,
0.016350046,
0.0044348165,
-0.003997346,
0.005426639,
-0.01222914,
0.028772876,
-0.011868478,
0.0034012506,
-0.0117950095,
-0.0028819628,
-0.022053862,
0.0024611896,
-0.014920753,
-0.009717858,
-0.020678,
0.00094840955,
-0.0004086677,
0.0060744965,
-0.019021623,
0.0027350262,
0.0035565358,
0.0145066595,
-0.029227044,
-0.016376762,
0.019221991,
-0.036199857,
-0.03726849,
0.014239501,
-0.015481784,
0.023843817,
0.0069193826,
-0.040073644,
-0.007821039,
-0.017859487,
-0.04079497,
-0.008856275,
0.008422144,
0.0059976885,
0.007012888,
0.0035899305,
-0.011087041,
0.008154986,
-0.013905554,
0.020344052,
-0.0010076852,
-0.027463803,
0.012108919,
0.0041776774,
0.032887105,
-0.007988013,
-0.041516297,
0.000059953927,
0.02642189,
-0.017765982,
-0.005429979,
0.028799592,
-0.025486838,
0.019809738,
-0.0039739697,
0.021613052,
0.0033044058,
0.046378564,
0.020651285,
-0.017365245,
0.008101555,
-0.0013917242,
0.018487308,
-0.012770134,
-0.0046452032,
-0.01216903,
0.001658047,
0.01701794,
0.0021539584,
-0.037161626,
0.026916131,
-0.010886673,
0.02188021,
-0.019676158,
0.025433406,
0.025192965,
0.0032860388,
0.00027717603,
-0.018674318,
-0.0033110848,
-0.022628251,
-0.022521388,
0.0048756264,
-0.021239031,
0.0022491333,
0.005700476,
-0.0100651635,
-0.016176393,
0.008228455,
-0.015308131,
-0.01979638,
-0.016937794,
0.008522328,
-0.025446763,
-0.017472109,
-0.0034530123,
0.0038504093,
-0.008235134,
0.0013858802,
0.002262491,
0.007814361,
-0.011240657,
0.016523698,
-0.0051861973,
-0.029734643,
0.004942416,
-0.0041209063,
-0.0071665035,
-0.014039133,
0.011527851,
0.19929959,
-0.016109604,
-0.010619516,
-0.0027133196,
0.012456224,
-0.009878153,
0.0121957455,
-0.015455069,
0.00208049,
-0.016724067,
0.015495142,
0.0018834613,
-0.004842232,
-0.0041142274,
0.025486838,
-0.018353729,
-0.01891476,
-0.009964979,
-0.037856236,
-0.012656593,
0.020597853,
-0.011841762,
0.027116498,
-0.005616989,
0.031952053,
0.0006541187,
-0.017926276,
0.0050225635,
0.011314126,
0.023990754,
-0.042317767,
0.0074002664,
0.013037292,
0.009009891,
0.017418677,
0.0058106785,
0.0089030275,
-0.015294774,
0.019662801,
-0.0036834357,
0.004244467,
-0.00069127034,
-0.02099859,
0.0003237199,
0.010926747,
0.009510811,
0.017351888,
0.006752409,
0.0047453875,
0.012897034,
-0.023643449,
0.013377918,
0.0057104942,
0.024097618,
-0.011541209,
-0.012836924,
0.024097618,
0.024378134,
-0.009363875,
0.02043756,
-0.015334847,
0.02371024,
-0.035585396,
0.015294774,
-0.0029721286,
0.02389725,
-0.0061012125,
0.027076425,
0.037776086,
-0.04557709,
0.009230296,
0.03139102,
-0.016122963,
0.0012848612,
-0.013144155,
-0.03857756,
0.040634673,
0.016724067,
0.050198916,
0.040714823,
0.0002903252,
-0.0043346323,
-0.015615364,
0.015535216,
0.011167189,
-0.020838294,
0.023042345,
-0.017752625,
-0.04245135,
-0.017178236,
0.01286364,
-0.028104981,
-0.0112139415,
-0.014787175,
-0.013257697,
-0.016603846,
-0.01859417,
0.034703776,
-0.022160726,
-0.018166719,
-0.03630672,
0.044588607,
0.00048213603,
0.026475322,
-0.0065353434,
0.015254701,
-0.0006503618,
0.0065720775,
0.0063216174,
-0.008675944,
0.013064008,
0.007547203,
0.00933048,
-0.0027750998,
0.0032326072,
0.013057329,
0.009377233,
-0.017365245,
0.028024836,
-0.00033686907,
0.0062949015,
-0.040073644,
0.024765512,
0.02994837,
-0.0070195664,
0.016977867,
-0.0055201445,
-0.0018183416,
-0.012462903,
-0.028719444,
-0.009470738,
-0.010559405,
0.028906455,
-0.004521643,
0.011294088,
-0.02628831,
0.012683309,
-0.0076006344,
-0.026702404,
0.032993965,
-0.021866852,
-0.00800805,
0.014773817,
0.009303764,
-0.02074479,
-0.029146897,
0.01456009,
0.0032693415,
-0.017672477,
-0.0011871817,
-0.0062815435,
-0.0077208555,
-0.0020988572,
0.008108234,
0.013224303,
-0.010365716,
0.012002056,
-0.02452507,
-0.011494457,
0.015361563,
-0.047527343,
0.001935223,
0.012836924,
-0.009450701,
-0.0073735504,
-0.012209103,
-0.16798872,
0.02301563,
0.017164877,
-0.022040503,
0.03953933,
0.015094406,
0.0069327406,
-0.016109604,
-0.0011045298,
-0.004545019,
0.007914545,
0.0022675004,
-0.02598108,
-0.032753523,
0.008856275,
0.00460179,
-0.008736054,
0.041863598,
0.00958428,
0.0083086025,
-0.012369398,
0.0053297947,
0.0100651635,
-0.001601276,
0.0069127036,
0.019943317,
0.011087041,
-0.015201269,
-0.006348333,
-0.020477632,
-0.0025296488,
-0.005580255,
0.006261507,
-0.029227044,
0.018994907,
-0.0057205125,
-0.0022007108,
-0.01689772,
0.0024595198,
0.021987073,
0.012048809,
0.013671791,
-0.023122493,
-0.0066054724,
0.010940105,
0.038630992,
-0.023296146,
0.002527979,
0.010833242,
0.0035298201,
0.00485225,
-0.006121249,
0.010345679,
0.01286364,
0.015187911,
-0.020076895,
-0.00043454856,
0.014720385,
-0.010940105,
0.0029487524,
-0.0005005031,
-0.01185512,
0.035585396,
0.0006411783,
-0.02212065,
-0.0057739443,
-0.00094089576,
0.023416366,
-0.046325132,
-0.012269214,
0.009243654,
-0.0028652656,
0.0076273503,
0.007079677,
-0.0025112818,
0.011360878,
-0.021132167,
0.0065520406,
0.0046952954,
0.016804215,
-0.021920282,
0.0152680585,
-0.022775188,
-0.021078737,
-0.028666014,
-0.0023426383,
-0.00466524,
0.02282862,
-0.013224303,
0.00037861246,
0.03139102,
-0.0066555645,
-0.0049824896,
-0.0041476223,
0.009971659,
0.0374555,
-0.012035451,
-0.029841507,
-0.010819884,
0.006164662,
0.01349146,
-0.023149207,
-0.014586806,
0.012048809,
0.04199718,
0.015655437,
-0.020223832,
0.027356941,
0.05930899,
-0.009096717,
-0.0034363149,
0.0040006856,
-0.001235604,
0.0162699,
-0.004501606,
0.027089784,
0.013070687,
0.012609839,
0.0131508345,
-0.014787175,
0.06972814,
0.014680311,
-0.0041142274,
0.01027889,
-0.030509401,
-0.009350517,
-0.123426825,
0.0020153704,
0.0108466,
0.002180674,
-0.016216468,
-0.0016680654,
-0.0022908766,
0.022641608,
-0.02181342,
0.019061696,
-0.005837394,
-0.022347735,
0.023563303,
-0.009751253,
0.001683928,
0.009363875,
0.020718073,
-0.014359722,
-0.004324614,
0.051347695,
-0.0011688146,
0.013985702,
-0.010512653,
-0.011888514,
0.009530848,
-0.008776128,
-0.033715293,
0.03133759,
0.019876527,
-0.0014960828,
0.0034663703,
-0.027704246,
0.01847395,
0.005667081,
-0.03545182,
-0.010572763,
-0.008261849,
-0.03435647,
0.036787603,
0.0043914034,
-0.006221433,
-0.017912919,
0.0029454129,
-0.009383911,
0.015815731,
0.0011604659,
0.008001371,
0.009170186,
0.02571392,
0.0002990913,
-0.03574569,
-0.038684424,
-0.040821686,
-0.025620416,
0.008749412,
-0.011708183,
0.00045166336,
-0.009310443,
-0.028479002,
0.018634245,
-0.0060377624,
-0.0076741027,
0.0005393245,
0.011694825,
0.011267372,
-0.028479002,
-0.012623197,
-0.00927037,
0.020731432,
-0.027704246,
-0.017365245,
0.01160132,
-0.008849597,
0.01689772,
-0.023362935,
-0.008856275,
-0.051748432,
-0.024364775,
0.006107891,
-0.031364307,
-0.012643235,
-0.01683093,
0.014974185,
-0.024672007,
0.03171161,
0.006147965,
0.000838207,
-0.011380915,
0.0071665035,
-0.022454599,
-0.021332536,
0.032139063,
-0.0145066595,
-0.022481315,
-0.038176823,
0.012770134,
0.0025864197,
0.011434346,
0.011688146,
0.031310875,
-0.012309288,
-0.018433876,
-0.07320119,
0.012275893,
-0.009190222,
0.0031157257,
0.007787645,
-0.0059475964,
-0.011173868,
-0.00479214,
-0.018246865,
0.01594931,
-0.012710024,
-0.004368027,
-0.032379504,
-0.012509656,
-0.03561211,
-0.030295674,
0.021639768,
-0.011668109,
0.0015787346,
0.03416946,
0.007527166,
-0.003599949,
0.029520918,
0.022361092,
-0.029601065,
-0.006859272,
-0.022708397,
0.0018200113,
-0.0121823875,
-0.006939419,
0.006201396,
-0.02994837,
-0.009196901,
0.012716703,
0.0007096374,
-0.020664642,
-0.015481784,
0.016750783,
0.00092753785,
0.02786454,
0.0020070216,
-0.04197046,
-0.002755063,
-0.006248149,
-0.013918912,
0.003883804,
-0.041649874,
0.0052429684,
0.008161666,
-0.011708183,
0.018019782,
0.005386566,
0.0016463589,
-0.017472109,
-0.0069193826,
-0.007854434,
-0.007273366,
-0.019235348,
0.0035164622,
-0.032993965,
0.02855915,
0.036894467,
0.01222914,
0.002659888,
0.0019752968,
-0.009357195,
-0.0160161,
-0.010091879,
0.0089163855,
-0.023883892,
-0.03473049,
0.014680311,
-0.00066163257,
0.0076340293,
0.008201739,
0.016790858,
-0.011928588,
-0.009737896,
-0.032673378,
0.03392902,
0.00068333914,
-0.0031825153,
0.000570632,
0.014813891,
0.030856706,
-0.0023192621,
-0.024297986,
0.010813205,
0.0065921145,
0.0068058404,
-0.006505288,
0.0018884705,
-0.00025839152,
0.00870266,
0.0034463333,
0.008529007,
-0.01248294,
0.001204714,
0.0148940375,
-0.006348333,
-0.009904869,
-0.0011003554,
0.0088763125,
-0.014693669,
-0.013498139,
0.015428353,
-0.014586806,
-0.026648972,
0.0056904573,
-0.0015645418,
0.0028352102,
-0.0051995553,
0.0019168559,
-0.0014718715,
-0.012583124,
0.015815731,
-0.019876527,
-0.018954834,
-0.0058607706,
0.022895409,
0.027811108,
0.018500665,
0.012596482,
-0.0066154907,
0.012997218,
-0.016523698,
0.02818513,
-0.007093035,
0.02326943,
-0.010920068,
0.02616809,
0.019302139,
-0.0035565358,
-0.0016805885,
-0.0065820958,
-0.0046418635,
0.009964979,
0.026114658,
-0.008061482,
0.10461893,
0.032192495,
-0.023990754,
-0.003636683,
-0.02445828,
0.020450916,
0.019128487,
0.0100852,
-0.021613052,
-0.013564928,
0.032940537,
-0.029921655,
-0.0018701034,
-0.007547203,
-0.0031374323,
0.023817101,
-0.010452542,
-0.0030673034,
0.013017255,
-0.012048809,
0.0065653985,
-0.01657713,
-0.0040708142,
0.0065353434,
-0.04808837,
-0.005309758,
0.017164877,
-0.0026431908,
-0.020611212,
-0.008829559,
0.015455069,
-0.011026931,
-0.020678,
0.005416621,
0.015147837,
0.0044314773,
-0.011147152,
-0.011434346,
0.037989814,
0.03245965,
0.007974655,
-0.012155672,
0.016350046,
-0.019475792,
0.023964038,
0.015374921,
0.008909707,
-0.0073334766,
-0.01166143
] |
Within hosts, RNA viruses form populations that are genetically and phenotypically complex. Heterogeneity in RNA virus genomes arises due to error-prone replication and is reduced by stochastic and selective mechanisms that are incompletely understood. Defining how natural selection shapes RNA virus populations is critical because it can inform treatment paradigms and enhance control efforts. We allowed West Nile virus (WNV) to replicate in wild-caught American crows, house sparrows and American robins to assess how natural selection shapes RNA virus populations in ecologically relevant hosts that differ in susceptibility to virus-induced mortality. After five sequential passages in each bird species, we examined | [
-0.016222011,
-0.009553701,
0.005252208,
-0.0075259493,
0.007339795,
0.0076988065,
0.0074727624,
0.014387062,
-0.025729172,
-0.026008403,
-0.007665565,
0.00016579361,
-0.029226212,
-0.0055613574,
0.008915458,
-0.00057466805,
0.033188637,
-0.032071713,
0.009314359,
-0.007891609,
-0.041858107,
0.0280561,
0.00011073683,
-0.01890795,
-0.0024100323,
0.03313545,
0.003643304,
-0.025423348,
-0.00021440977,
0.004338058,
0.016607616,
-0.0074794106,
-0.013516126,
-0.018668609,
-0.010304966,
-0.010657329,
0.007958093,
-0.031007973,
0.012352662,
-0.007851719,
0.004976301,
0.018695202,
-0.00063201017,
0.010544307,
0.00063076365,
0.014200907,
-0.003606738,
0.018562235,
-0.0030565858,
0.009467272,
0.02459895,
0.01114266,
-0.025609503,
0.009194689,
-0.009241227,
0.0069475416,
0.013436345,
-0.00037874904,
0.015211459,
-0.019958392,
-0.0023402246,
0.009201337,
-0.01573003,
0.014480139,
-0.027923133,
0.018389378,
0.007871664,
0.00027445282,
0.01634168,
0.02183323,
0.04720339,
0.0013629148,
-0.007373037,
0.009719909,
-0.0025280407,
-0.005288774,
-0.023322465,
0.018056959,
0.0064721834,
0.012518872,
0.0028521486,
-0.028508188,
0.0049064932,
0.0140413465,
0.016089043,
0.00026884326,
-0.0012631894,
0.015517284,
0.0016554429,
0.01333662,
0.018522345,
0.017338935,
0.004348031,
0.012093375,
-0.019466413,
-0.0012100025,
-0.020849273,
0.010757054,
0.0018432592,
-0.020703008,
-0.009380843,
0.02159389,
-0.0057275663,
-0.009852877,
0.0005314537,
-0.0065486394,
-0.0038327824,
-0.024824996,
0.0046571796,
-0.000045032284,
-0.010012438,
0.017658057,
-0.0112290885,
-0.031327095,
0.0280561,
0.013775412,
0.023123013,
-0.02874753,
-0.004221712,
-0.0073530916,
0.004461053,
0.0052156425,
0.020875866,
-0.026247745,
0.022710815,
-0.0020809383,
-0.014998712,
0.009168095,
-0.017219266,
-0.011827441,
0.011893925,
0.0060234186,
0.027710386,
0.012259585,
-0.021407735,
0.010796945,
-0.024412796,
-0.020729601,
-0.024040489,
0.003133042,
0.0116346385,
0.026460493,
-0.025263786,
0.007964741,
0.0070472667,
0.009301063,
0.036858536,
-0.0027906513,
0.0203307,
-0.0008892188,
-0.0029551983,
0.0029252805,
0.037151065,
-0.011295572,
-0.0058173193,
0.022923563,
-0.023521915,
0.03973063,
-0.0024100323,
-0.024585653,
0.0075924327,
-0.0010645695,
-0.00162137,
-0.0025562963,
-0.0059137205,
0.019945094,
0.019200478,
0.005135862,
0.002401722,
-0.007911555,
-0.006664986,
0.013389807,
-0.029226212,
0.035688423,
0.025968514,
0.014652996,
0.00044959568,
0.01398816,
-0.020968944,
-0.000072716495,
0.000041941832,
0.026766317,
0.02455906,
-0.00095653353,
-0.006528694,
-0.011089473,
0.03789568,
-0.011215792,
0.0243995,
0.012465685,
-0.019506304,
-0.0032726577,
0.010903318,
-0.009673371,
-0.64547646,
-0.02390752,
0.007499356,
-0.013748819,
0.0032992512,
0.006043364,
0.019054214,
-0.017870804,
-0.015158272,
0.04342712,
-0.011335462,
-0.008443424,
0.045395035,
-0.01679377,
-0.020556744,
-0.046378992,
0.017312342,
-0.0004666321,
0.019253666,
0.010484472,
-0.02493137,
0.0068012774,
0.001730237,
0.021274768,
0.0046538557,
0.011242385,
0.0007782742,
-0.022644332,
-0.013828599,
0.011209143,
-0.025037743,
0.050314825,
-0.021394439,
-0.0041951183,
0.04656515,
0.0009689992,
0.005587951,
0.034996994,
0.008563094,
0.01402805,
-0.008802435,
0.004786823,
0.01256541,
-0.0035236333,
0.0021457598,
-0.0052987467,
-0.019652566,
0.00050693785,
0.0046538557,
-0.022232132,
0.0005119241,
0.0133831585,
-0.02346873,
0.0065120733,
0.008536501,
-0.013097279,
-0.0017584926,
-0.043400526,
0.022032682,
0.005990177,
-0.0260217,
-0.0008717669,
0.000021620172,
-0.028800717,
-0.010557604,
0.0033989765,
-0.0045674266,
0.0051092687,
0.00019560737,
-0.021474218,
0.016075747,
0.03512996,
0.0014327227,
-0.01898773,
0.0042715743,
0.053027358,
-0.009606888,
-0.0099393055,
-0.01321695,
-0.0011775916,
-0.015995966,
-0.008250621,
-0.021447625,
0.013735522,
-0.004151904,
-0.015863,
-0.015676845,
0.024997853,
0.0154508,
0.0077121034,
0.007898257,
0.024160158,
-0.0016812052,
-0.015171569,
-0.028162474,
0.0146397,
-0.0031230694,
0.0020194408,
0.00473696,
-0.016195416,
-0.016421461,
-0.017977178,
0.010896671,
-0.019266961,
0.004700394,
0.005248884,
0.0034305563,
-0.012964312,
0.033215232,
-0.018602125,
0.009141502,
-0.014652996,
0.009985845,
0.003772947,
0.009826283,
-0.026992362,
0.0131039275,
0.010983099,
0.003079855,
-0.048772406,
0.01833619,
0.016926738,
0.0073132017,
-0.0041485797,
0.020197732,
0.0035867929,
-0.0075392458,
-0.03013039,
-0.023575103,
-0.008709358,
0.013389807,
-0.0075325975,
0.034252375,
-0.0059635835,
0.002838852,
0.0059702317,
-0.003989019,
0.009453975,
-0.005461632,
-0.019160587,
-0.02716522,
-0.006073281,
-0.0036566008,
-0.015464097,
-0.021992791,
0.001220806,
-0.011787551,
-0.020623228,
-0.009746503,
-0.014426952,
0.027391264,
-0.01293107,
-0.0067181727,
0.019266961,
-0.0007437858,
0.0069342447,
0.004677125,
-0.03505018,
-0.013170411,
0.0043945694,
0.018402673,
0.012020244,
0.015889592,
0.003207836,
-0.008602984,
-0.010105515,
-0.00012247535,
-0.008995238,
0.02382774,
-0.050979663,
0.0187085,
-0.01016535,
0.001000579,
-0.0034139354,
-0.0025031094,
0.017126188,
-0.021859825,
0.022577848,
-0.016620912,
-0.0032809682,
0.010644033,
-0.0040687993,
-0.026287636,
-0.022338506,
0.005258857,
0.009061721,
0.03949129,
-0.0012989243,
0.040847555,
0.043214373,
0.016541133,
0.022737408,
-0.003372383,
0.007918202,
0.0178974,
-0.034491718,
0.021155097,
0.024864884,
0.0005173259,
0.028215662,
0.013030795,
-0.007432872,
-0.0015956076,
-0.01902762,
0.020277513,
-0.014493436,
0.015397613,
-0.01394827,
-0.0038028648,
0.019120697,
0.018602125,
-0.0050361366,
-0.009134853,
-0.01402805,
0.003096476,
0.0096600745,
-0.020157842,
0.0028006237,
-0.020091359,
-0.0007649775,
-0.025848843,
-0.0051491586,
0.015264646,
-0.0058239675,
-0.03326842,
0.008463369,
-0.00542839,
0.015982669,
0.015995966,
-0.007565839,
-0.005049433,
0.00951381,
0.013722225,
0.0007292425,
0.023069827,
0.016035857,
-0.005355258,
-0.011807496,
0.021168394,
-0.000106997126,
-0.008616281,
-0.021234877,
-0.007838422,
0.0028671073,
0.032789737,
-0.01630179,
0.034917213,
0.023402244,
-0.029013464,
-0.0034139354,
-0.01618212,
-0.0019230396,
-0.013004201,
0.007858368,
0.007997983,
-0.02143433,
0.015982669,
-0.006575233,
0.045980092,
0.027151922,
0.004677125,
-0.01736553,
0.0069275964,
-0.016381571,
0.005099296,
0.000085961285,
-0.014174314,
-0.017192671,
-0.008004632,
0.0174852,
-0.029492147,
-0.030156983,
0.0017767756,
0.0045973444,
-0.0024515847,
0.0050361366,
-0.0252106,
0.0113820005,
0.0013172074,
0.0049497075,
-0.01890795,
0.0021274767,
0.024452686,
0.015796514,
-0.008543149,
-0.022591144,
0.0033025753,
-0.002315293,
-0.0071469923,
0.006571909,
0.008569743,
0.002004482,
-0.017006518,
0.01402805,
-0.010118811,
-0.0058904514,
0.017990476,
-0.025449941,
0.008137599,
-0.008310456,
0.0048134164,
-0.0077852355,
0.0007001559,
-0.012711674,
0.015397613,
0.0031097727,
0.0016487945,
-0.018269707,
-0.019758942,
-0.008283863,
0.009075019,
-0.015384316,
0.0022853755,
-0.00666831,
-0.012631893,
-0.0007321512,
-0.040262498,
0.009035128,
0.0268328,
-0.008775841,
-0.0096866675,
-0.029226212,
-0.015517284,
-0.012864586,
0.054277252,
0.019493006,
-0.013934973,
0.03797546,
0.032470614,
0.010836835,
0.0018432592,
-0.021181691,
0.028694343,
-0.019054214,
-0.0009922684,
0.002006144,
0.035156555,
0.017857509,
0.026965769,
0.028375221,
-0.0025812278,
-0.03465128,
-0.02256455,
0.01679377,
0.0112556815,
-0.010624087,
-0.006611799,
0.018309597,
0.021819934,
0.004886548,
-0.010424636,
0.00038456637,
0.0016803743,
-0.022870375,
-0.018003773,
0.010451229,
-0.015636954,
0.028029507,
0.013841896,
-0.03021017,
0.016860254,
0.0069342447,
-0.0014476815,
-0.0010155378,
0.019453116,
0.008968645,
0.0135094775,
0.014958821,
0.008177489,
-0.011175902,
0.009606888,
0.008556446,
-0.021354549,
-0.035475675,
0.0049463836,
-0.0009972547,
-0.005119241,
-0.0075392458,
0.015663547,
0.010903318,
0.012585355,
0.01195376,
-0.023282574,
-0.033029076,
-0.04494295,
-0.018522345,
0.021474218,
-0.005661083,
-0.01126233,
-0.0092811175,
-0.017498497,
0.00906837,
-0.014453545,
-0.022139056,
0.019439818,
-0.03390666,
-0.009527107,
0.0040156124,
0.017751135,
0.022777298,
0.016009264,
-0.026526976,
-0.008343698,
0.00968002,
-0.007612378,
-0.0023468728,
0.006505425,
-0.029199619,
0.0033657348,
-0.0024283153,
-0.009267821,
-0.007193531,
-0.013409752,
-0.006814574,
-0.009048425,
0.0074661137,
0.009753152,
0.0066516893,
-0.0092811175,
0.022085868,
0.03204512,
0.027391264,
-0.0029768054,
-0.014134424,
0.019945094,
-0.015743328,
-0.014466842,
-0.01016535,
-0.011209143,
-0.03989019,
-0.008769194,
-0.00006819768,
-0.025715876,
-0.02842841,
0.028641157,
-0.028694343,
0.020304106,
0.020835975,
0.029252807,
0.015118382,
0.017259156,
-0.01647465,
0.014799261,
-0.000026489579,
-0.0064888042,
-0.016208714,
0.013855193,
0.0077519934,
-0.020104656,
0.021686966,
-0.003806189,
-0.026925879,
-0.01979883,
-0.00768551,
0.006395727,
0.044065364,
0.019493006,
-0.03505018,
-0.016381571,
0.005248884,
0.004095393,
0.003369059,
-0.007944796,
-0.022511363,
-0.0068079256,
0.015849702,
0.009301063,
0.002970157,
-0.0035236333,
-0.03435875,
0.015916185,
0.021780044,
-0.0028072721,
0.0070007285,
-0.009321008,
-0.02541005,
-0.0048566307,
-0.008410182,
-0.016288495,
-0.011774254,
-0.006206249,
0.0037064634,
0.03028995,
-0.0023053205,
0.0292794,
-0.0054915496,
0.008217379,
0.015836405,
0.004517564,
0.013775412,
-0.007632323,
-0.0030848414,
0.015849702,
0.007738697,
0.025277084,
-0.0011850711,
-0.004610641,
-0.022192242,
0.020224325,
0.0011327151,
-0.0017734513,
-0.022272022,
-0.021168394,
-0.022045977,
-0.014666293,
0.008396885,
-0.021740153,
0.01126233,
-0.00510262,
-0.0014667956,
-0.0016645844,
-0.013236894,
0.010909967,
-0.005282126,
0.0030349786,
0.0062627597,
0.015038601,
-0.010883373,
0.01602256,
-0.02517071,
-0.00049281004,
-0.03350776,
0.007904906,
0.017697947,
0.0003278475,
-0.0012731618,
0.009075019,
0.017697947,
-0.004886548,
0.026128074,
-0.02256455,
-0.026739724,
0.0028022858,
-0.0027191814,
-0.003480419,
-0.023614991,
-0.0037596503,
-0.01166788,
-0.01691344,
0.004517564,
0.0025446618,
-0.00979969,
-0.03180578,
-0.035289522,
0.022657627,
-0.019532897,
0.032311052,
-0.0027574094,
0.021620482,
0.0067414423,
-0.02333576,
-0.022551253,
-0.004793471,
-0.010364801,
0.011169253,
0.022657627,
0.013655742,
-0.007486059,
-0.033188637,
0.009414085,
-0.014573216,
0.009926009,
-0.035236333,
0.02728489,
-0.009321008,
0.02049026,
-0.010604142,
-0.014107831,
0.0005131707,
0.03164622,
-0.0064921286,
0.0019363363,
0.015437503,
-0.024412796,
-0.014214205,
-0.0007284115,
0.017139485,
0.014998712,
-0.020463668,
-0.012611948,
0.0030466132,
-0.03236424,
-0.0025995106,
0.005930342,
-0.020609932,
0.040395465,
0.0018316245,
-0.016222011,
-0.0032028498,
0.0007778587,
0.0016097354,
0.002898687,
-0.027923133,
0.04042206,
-0.027018955,
-0.015517284,
0.010644033,
0.02329587,
0.00062037556,
0.018695202,
-0.008184137,
-0.020264216,
-0.009420733,
0.01008557,
0.023029936,
0.014506732,
0.0021224904,
0.0042316844,
0.00044751808,
0.0011443498,
-0.037443593,
-0.020503558,
0.012033541,
-0.02598181,
0.009387491,
-0.0107238125,
-0.002260444,
0.037762713,
0.033188637,
0.0007180234,
-0.006026743,
0.043453712,
-0.009926009,
0.0065652602,
0.0107238125,
0.0008883878,
-0.032816328,
0.006721497,
-0.008602984,
-0.012798103,
0.03138028,
-0.005667731,
-0.025303677,
-0.02394741,
-0.020224325,
0.024226641,
0.01675388,
-0.01606245,
0.029598521,
0.0015515622,
0.0018349488,
-0.002132463,
-0.012040189,
0.041804917,
0.0047834986,
0.0017335612,
0.0010479485,
-0.0026427251,
0.013110575,
0.0034937158,
0.0070073768,
0.018562235,
-0.024878182,
-0.02781676,
-0.016354978,
0.008017928,
0.004461053,
-0.0071868827,
0.01967916,
-0.0027225055,
-0.0101919435,
-0.0058139954,
0.0006087409,
-0.020703008,
-0.023349058,
0.01390838,
0.0047702016,
-0.0028488245,
-0.01471948,
0.0046505313,
0.0004903169,
-0.025263786,
-0.026473789,
-0.00094656093,
-0.01268508,
0.035076775,
0.021354549,
0.00445108,
-0.0096600745,
-0.0007450324,
-0.053000767,
-0.003899266,
0.0040521785,
0.013655742,
-0.0012681757,
0.028215662,
0.012771509,
0.0035502268,
-0.017205968,
0.0068544643,
0.013037444,
-0.0062926775,
0.0023019963,
0.0009714923,
-0.0025213924,
0.022311913,
-0.02829544,
0.006827871,
0.026101481,
-0.008622929,
-0.019160587,
-0.0044776737,
-0.017950585,
0.0021042074,
-0.017963883,
0.024213346,
0.0030931518,
0.0010795282,
0.005504846,
-0.033002485,
-0.03850733,
0.027338076,
-0.020556744,
-0.02890709,
-0.00082647486,
-0.028614562,
0.0142939845,
0.017963883,
-0.026154667,
-0.039996564,
0.013150466,
0.008343698,
0.018362785,
0.0053486098,
0.020902459,
0.026952472,
-0.0018199899,
-0.014865744,
-0.00032639317,
-0.020197732,
0.00048782377,
0.024439389,
0.0033673968,
0.01533113,
-0.017844211,
0.004384597,
0.0133831585,
-0.021793341,
0.0026543597,
-0.0001690139,
-0.02517071,
-0.016620912,
0.010265076,
0.009267821,
-0.003809513,
0.02525049,
-0.013529423,
-0.0042915195,
-0.020929053,
0.0028205689,
0.0050028944,
0.0074661137,
0.038986012,
0.01350283,
-0.00058214745,
0.0140147535,
0.013775412,
-0.008024576,
-0.027949726,
0.009819635,
0.16562407,
-0.007831774,
0.009706613,
0.01959938,
-0.009992492,
-0.004175173,
0.0125720585,
0.021088613,
0.0039624255,
-0.007997983,
0.03473106,
0.005903748,
0.0042915195,
0.009566997,
-0.0036000896,
-0.01049112,
-0.029492147,
-0.022511363,
-0.019984985,
0.014054644,
0.0076788617,
-0.010517714,
-0.0053053955,
-0.005554709,
0.03183237,
0.030396326,
-0.041858107,
0.009999141,
-0.0104711745,
0.0017335612,
-0.017378826,
-0.013024147,
0.004623938,
0.011794199,
0.0148258535,
0.0018133415,
0.010351504,
0.018814873,
0.006518722,
0.008895513,
-0.007014025,
0.015424207,
-0.0042316844,
-0.013456291,
0.0027358022,
0.020915756,
0.0002815167,
0.004095393,
-0.021155097,
-0.0018648664,
-0.02578236,
-0.00991936,
-0.019333445,
0.0056710555,
-0.008563094,
0.005119241,
0.012252937,
-0.012312772,
-0.028534783,
0.03643304,
-0.022338506,
0.011860684,
-0.016687397,
0.002094235,
-0.0112290885,
0.044091955,
-0.018575532,
0.0037662988,
-0.0013562664,
-0.017139485,
0.006761387,
-0.016089043,
-0.008483314,
0.021221582,
0.009227931,
-0.0071536405,
0.013476236,
0.02272411,
0.02866775,
0.017631464,
-0.008363643,
0.017990476,
-0.044331297,
0.024745215,
-0.00200282,
-0.04842669,
0.040315684,
-0.006631744,
-0.026979065,
0.0034903917,
0.015623658,
0.005900424,
-0.016846957,
-0.010371449,
0.023548508,
0.0017385475,
-0.00015322404,
0.00009863473,
0.0019346742,
-0.023349058,
-0.034996994,
0.07419575,
0.012751564,
0.016647507,
0.01606245,
0.022963453,
-0.003372383,
0.0019878612,
0.014200907,
-0.026167965,
-0.0098129865,
-0.021686966,
0.028242255,
0.006701552,
0.01289118,
0.0067480905,
0.019306852,
-0.0333482,
0.027191812,
0.019998282,
-0.009965899,
-0.03382688,
-0.012558761,
0.040687993,
0.007851719,
-0.012086728,
-0.033188637,
0.016288495,
-0.006595178,
-0.025729172,
0.0065486394,
-0.0065918537,
-0.016235307,
-0.008975293,
0.005883803,
-0.020729601,
0.014998712,
-0.047389545,
0.0033275066,
-0.005208994,
-0.008882215,
-0.019785535,
0.023521915,
0.008423478,
-0.00003428063,
-0.019147292,
0.018110147,
0.005923693,
-0.001858218,
0.0011285599,
-0.010610791,
-0.013423049,
0.007120399,
0.024080377,
-0.011581452,
-0.009832932,
-0.0182963,
-0.026726427,
-0.0024465984,
-0.0075325975,
-0.035555456,
0.016448054,
0.0011219116,
-0.032337647,
0.0054716044,
-0.015264646,
-0.16679418,
0.006192952,
-0.006827871,
-0.011501672,
0.03013039,
0.004660504,
0.026513679,
-0.015397613,
-0.00731985,
0.019147292,
0.022923563,
0.025051039,
-0.040076345,
-0.013828599,
0.023482025,
0.008935402,
-0.010683922,
0.02228532,
0.009586942,
0.0047602295,
0.036459632,
-0.038693484,
0.009726558,
-0.026447196,
-0.011741012,
0.02159389,
-0.0045474814,
0.0019247016,
-0.017684652,
-0.030263357,
0.0022986722,
0.0096866675,
0.01821652,
-0.022830484,
0.022378396,
0.0027374644,
0.0026011728,
0.004151904,
-0.010730461,
0.018735092,
0.038374364,
0.02240499,
0.007140344,
0.006827871,
-0.010132108,
0.017152783,
-0.0029119838,
-0.003952453,
-0.005132538,
0.0047303117,
0.015517284,
0.003516985,
0.015703438,
0.0061264685,
0.020343997,
-0.0128512895,
-0.020716306,
0.029332586,
0.027058845,
-0.018349487,
-0.020915756,
-0.042336788,
0.039225355,
-0.012857938,
-0.010311614,
-0.010770352,
-0.024213346,
0.012352662,
-0.025516424,
0.006063309,
-0.018841466,
0.016846957,
-0.0017983827,
-0.0060766055,
0.015091788,
0.026074888,
-0.010005789,
0.01569014,
-0.025316974,
-0.013310026,
0.0033956524,
0.029997423,
-0.006103199,
-0.016009264,
0.019918501,
-0.0068810578,
0.008277214,
0.008323753,
0.0048566307,
-0.0028022858,
-0.002893701,
-0.007213476,
-0.001331335,
-0.024173455,
0.007200179,
0.028534783,
0.021992791,
0.0027723683,
0.018562235,
-0.010657329,
0.0029186322,
-0.014985414,
-0.025104227,
0.008157544,
0.036885127,
-0.011375353,
-0.0030732066,
0.01687355,
0.055473957,
-0.0071735857,
-0.019293556,
0.028800717,
0.009733207,
0.0053585824,
-0.0063126227,
0.020889163,
-0.016434759,
-0.008981941,
-0.0049031693,
-0.022670925,
0.061218146,
0.017671354,
-0.024213346,
-0.0017817618,
0.025848843,
-0.02943896,
-0.14424293,
-0.026566867,
-0.016049152,
0.019586083,
-0.031885557,
0.042842064,
-0.012332717,
0.027869945,
-0.024612248,
0.028029507,
-0.026979065,
-0.012126618,
-0.011175902,
-0.010278372,
0.015716735,
0.006428969,
0.011029637,
-0.0053652306,
0.004221712,
0.017338935,
0.0019064187,
-0.028322035,
-0.018429268,
0.0027225055,
0.013316675,
0.002569593,
-0.012771509,
-0.002094235,
0.011647935,
-0.0020892487,
-0.001803369,
-0.0024349636,
-0.0052322634,
-0.028534783,
-0.026992362,
0.0030283302,
-0.025436644,
-0.020809382,
0.008410182,
-0.01142854,
0.008981941,
0.007067212,
0.018455861,
-0.009367546,
0.012173156,
-0.0052256146,
-0.0019961717,
0.01902762,
-0.01936004,
0.0004807599,
-0.0062029245,
-0.012651838,
-0.04204426,
-0.02989105,
0.0006315947,
-0.021394439,
0.005006219,
0.026566867,
-0.0074594654,
0.0016645844,
-0.0105709005,
0.009945954,
-0.026407305,
0.0020111303,
0.013974863,
-0.020264216,
-0.011488374,
-0.019586083,
0.016860254,
-0.031991933,
-0.006335892,
-0.010185295,
-0.0009872821,
0.0040887445,
-0.019466413,
0.011927167,
-0.038214803,
-0.011561506,
0.011973705,
-0.005338637,
-0.0068544643,
-0.022950156,
0.024944665,
-0.04941065,
0.009806339,
0.032550395,
0.012758212,
0.0070206732,
-0.006901003,
-0.009048425,
-0.015012008,
-0.00037958007,
-0.026885988,
-0.019320149,
0.0061065233,
0.013050741,
-0.03427897,
-0.025755767,
0.024173455,
0.0041186623,
-0.022298615,
0.0032460643,
-0.034066223,
0.020051468,
-0.02106202,
-0.03313545,
-0.008622929,
-0.012326068,
0.0032809682,
-0.007612378,
-0.0187085,
0.010371449,
-0.027763572,
0.018070256,
-0.0033657348,
0.001185902,
-0.027338076,
-0.006558612,
0.010524361,
0.0031164212,
0.03180578,
0.040368874,
-0.0063658096,
0.015184865,
0.012332717,
0.002644387,
0.0007815984,
-0.02582225,
0.00033740452,
0.013376511,
-0.014426952,
-0.01936004,
-0.0005680197,
-0.0080644665,
-0.0068046018,
0.0030233439,
0.0145466225,
-0.012671784,
0.011495023,
0.016448054,
0.016487945,
0.046777897,
-0.051165815,
-0.040209312,
0.004623938,
-0.0073996303,
-0.008656171,
0.018721797,
-0.024213346,
0.023561805,
0.0049397354,
-0.009374195,
0.03066226,
0.0053220163,
-0.018735092,
-0.018854763,
-0.026952472,
0.019001028,
0.010251779,
-0.007791884,
0.0068810578,
-0.010943209,
0.0070206732,
0.013682335,
0.013070686,
0.0048499824,
-0.01760487,
-0.019426523,
-0.003935832,
-0.0030083852,
0.004171849,
-0.021567296,
-0.017392123,
0.014586513,
0.018349487,
-0.006252787,
-0.0051292134,
-0.0053884997,
-0.0045242123,
0.012818048,
0.0049098176,
-0.0010138757,
0.0005426728,
0.012957663,
-0.023229387,
0.041219864,
0.038773265,
0.008137599,
0.0024133564,
0.029625114,
0.00298844,
0.017139485,
0.0006249463,
0.02700566,
0.012053486,
0.023508618,
-0.008024576,
0.016647507,
-0.0133565655,
0.024146862,
0.034784246,
0.040714588,
0.014586513,
0.013642445,
0.0045242123,
-0.049357463,
-0.009706613,
0.0049330867,
-0.017671354,
-0.011760958,
0.0060367156,
-0.0008177489,
0.0009864512,
0.005810671,
-0.013841896,
-0.0072932565,
0.0029635087,
0.020835975,
-0.030476104,
0.004175173,
-0.025463238,
0.0162619,
0.01841597,
0.012678432,
-0.0025862139,
-0.0036831943,
-0.0025812278,
0.028348628,
0.019785535,
-0.039384913,
0.026899284,
-0.023601696,
0.020463668,
-0.02183323,
-0.028162474,
-0.0007126216,
-0.010158702,
-0.0018349488,
0.012146562,
0.01663421,
-0.015716735,
0.05808012,
0.012392553,
-0.0020493586,
-0.0112290885,
-0.03872008,
0.017405419,
0.023442134,
-0.0021806636,
-0.008423478,
-0.029917642,
0.017139485,
-0.009500514,
0.020742899,
-0.027391264,
-0.013143818,
0.014413655,
-0.016926738,
0.034411937,
-0.020397184,
0.008450072,
0.03183237,
-0.0027407885,
0.045687564,
-0.0033075616,
-0.032257866,
-0.010285021,
0.031114347,
-0.012831344,
0.0044710254,
-0.008735952,
-0.017578278,
0.011581452,
-0.027763572,
-0.0070938054,
-0.018509049,
-0.00064572244,
0.00735974,
-0.022152351,
0.027311483,
0.018163333,
0.006339216,
-0.016966628,
0.005278802,
-0.04050184,
0.011076176,
-0.003789568,
-0.022843782,
-0.0045674266,
-0.010909967
] |
Data acquisition packages developed at different small angle scattering facilities use different formats both for raw and processed data storage. To facilitate the data exchange between laboratories, a consensus in the small angle scattering community has been reached on an ASCII format for one-dimensional data which includes a self-describing header containing relevant information about the sample and instrumental conditions followed by raw or reduced data in a tabular form. This format called sasCIF was implemented as an extension of core CIF (Crystallographic Information File) dictionary. | [
0.00096828217,
0.023714723,
0.0107813,
-0.018651718,
-0.022859393,
0.027798235,
-0.0063356524,
-0.021838514,
-0.009277575,
-0.022459319,
0.031343717,
0.021424644,
0.0011536613,
0.018513761,
-0.0115745505,
0.013457657,
0.010050131,
0.011698711,
-0.010567468,
0.013768058,
-0.011926339,
0.027011883,
-0.02270764,
0.0060390458,
-0.004321487,
0.012816159,
0.00050526566,
-0.01433368,
-0.013533533,
-0.021893697,
0.0070357816,
-0.023673335,
-0.017423905,
-0.023507787,
-0.018844858,
0.002860873,
-0.01772741,
-0.0071530445,
-0.0014623388,
-0.00818082,
0.03101262,
-0.004649134,
0.0072841034,
0.011222761,
0.023425013,
-0.0023831986,
0.009774218,
-0.00796009,
-0.017465293,
0.016058136,
0.018279236,
-0.024776988,
-0.034737445,
-0.01623748,
0.013436963,
0.0112503525,
-0.0029815848,
0.01182977,
-0.011202068,
-0.021383258,
0.0004058939,
0.006556383,
-0.029026048,
0.026225531,
-0.0065977694,
-0.023866475,
0.028308675,
0.006556383,
0.0028832909,
0.011126191,
0.013057583,
0.037606943,
-0.018086096,
0.008518814,
0.010498489,
-0.0039248625,
-0.012222946,
0.0054216906,
-0.008725748,
-0.0016787582,
0.0015192459,
-0.015437332,
-0.0069288653,
-0.0034902995,
0.0075048334,
0.014278498,
-0.013719774,
0.02990897,
-0.018706901,
-0.015257989,
0.021976471,
0.020596905,
-0.0032626712,
-0.007525527,
-0.005714848,
0.0029039844,
0.035896283,
0.042104322,
-0.0153683545,
-0.012988605,
-0.01113309,
-0.010829586,
-0.0212453,
-0.014444046,
-0.018182667,
-0.014775141,
0.0048250286,
0.02305253,
-0.008898194,
-0.009815605,
-0.0007324628,
0.04116622,
0.011043418,
-0.010864074,
0.010408818,
0.0060045565,
0.0090706395,
-0.009312063,
0.005476873,
0.0010519183,
-0.00029617536,
0.009988051,
0.023024939,
-0.030488387,
0.013126561,
0.02109355,
-0.02239034,
-0.016609963,
0.0109882355,
-0.01484412,
0.017272154,
-0.0038938222,
0.017713614,
0.025452973,
-0.015244193,
-0.009208596,
-0.008015272,
0.019037997,
-0.022183405,
-0.022942167,
0.01528558,
0.017782593,
-0.036530882,
-0.02121771,
0.002052103,
0.008401551,
0.011491776,
0.000036294416,
0.0067253793,
-0.0072358185,
0.02844663,
-0.020031285,
0.016568575,
0.00060226634,
-0.0091327205,
0.007139249,
-0.006908172,
0.035813507,
-0.02102457,
-0.020307196,
-0.0094155315,
0.022914575,
-0.0027763746,
-0.022183405,
0.019106975,
0.023866475,
-0.01379565,
-0.03377175,
-0.0010993409,
-0.007656586,
0.00970524,
0.008677464,
0.0042628557,
-0.007463447,
0.01093995,
0.0082842875,
0.01706522,
0.022335157,
-0.031095395,
-0.023714723,
0.0014994147,
-0.00094845094,
0.014306089,
0.009518999,
-0.021700557,
-0.0031592038,
0.0035489309,
0.020086467,
0.008311879,
-0.005914885,
0.0000020292673,
0.01113309,
-0.01836201,
-0.008684361,
-0.64806443,
-0.036034238,
0.004900905,
-0.05562406,
0.019879531,
0.03413044,
0.006732277,
0.010353635,
-0.0021348768,
0.017092811,
-0.014568207,
0.028888091,
0.0024021675,
-0.02448728,
-0.020003693,
-0.012850648,
0.0016649625,
-0.009477612,
0.00079842325,
0.011850463,
-0.04226987,
0.020610701,
-0.0023314648,
-0.0010579539,
0.023921657,
-0.0025366752,
0.020845227,
-0.030267656,
-0.004887109,
0.010526081,
-0.0036144604,
-0.0030143496,
0.011540061,
-0.014306089,
0.048533097,
-0.008732647,
0.016706532,
0.0016089177,
0.043345932,
0.026432466,
-0.008332573,
-0.005076799,
0.017989527,
0.0067598685,
-0.026239326,
-0.008429142,
0.006314959,
0.008056659,
-0.0011579724,
-0.01975537,
-0.0054251393,
-0.019037997,
-0.0019520845,
-0.017037628,
0.038793366,
-0.0098569915,
0.0193415,
-0.02045895,
-0.0057665817,
0.011374514,
-0.0037317234,
-0.009077538,
-0.0066426056,
-0.028915683,
0.002547022,
-0.0024056165,
-0.011767689,
-0.013623204,
0.021355666,
-0.0053044274,
0.025894435,
0.01994851,
-0.006908172,
-0.011208965,
-0.019451866,
0.006145962,
-0.001666687,
0.012795465,
-0.018210258,
-0.0023349137,
0.003783457,
0.013285211,
-0.0313989,
-0.0074013663,
0.017892959,
0.008794727,
-0.009719036,
0.022638662,
0.010091518,
-0.0035523798,
0.013650795,
0.02248691,
0.0014675122,
-0.049774706,
-0.012754078,
0.019493254,
-0.013009298,
-0.015947772,
-0.004649134,
-0.010298452,
-0.020610701,
0.007953192,
-0.005607932,
0.0082842875,
0.010843381,
-0.0085464055,
0.0023607805,
-0.016720328,
0.029439917,
-0.028722543,
0.007835929,
0.008194616,
-0.02651524,
-0.02644626,
-0.0007630719,
-0.029081231,
0.015395945,
0.0193415,
-0.018334419,
-0.013057583,
0.0036420517,
0.006504649,
0.0237837,
0.0016528913,
-0.0102018835,
0.017575659,
0.024183774,
-0.0057872753,
-0.03655847,
-0.009539692,
-0.00954659,
-0.021369461,
0.0077393595,
-0.036227375,
0.027977578,
0.0098983785,
0.0075048334,
0.0068460912,
-0.015354559,
-0.0256875,
-0.02866736,
-0.017713614,
-0.0027091207,
-0.017782593,
-0.01718938,
-0.010946848,
-0.0058459067,
0.032392185,
0.018941427,
-0.008725748,
-0.018030915,
0.0023642294,
-0.008146332,
0.022514502,
-0.012995502,
-0.0051009418,
0.003507544,
-0.031233352,
-0.0018865551,
-0.0034420146,
-0.02644626,
0.027853418,
-0.037027523,
-0.011602142,
-0.01550631,
0.008477427,
0.00053285697,
0.026846334,
-0.013457657,
-0.02702568,
0.0073116943,
-0.010870973,
-0.03920724,
0.032171454,
-0.011878055,
0.033551022,
-0.014209519,
-0.010291555,
-0.0007423784,
-0.02527363,
-0.0021590192,
0.008560201,
-0.01867931,
-0.005400997,
0.015685653,
0.03570314,
-0.0014071563,
0.007525527,
0.0028470773,
0.023687132,
0.021010775,
-0.0073806727,
0.00004766505,
0.0024245854,
-0.02565991,
-0.005528607,
-0.0036834385,
-0.00970524,
-0.0073530814,
0.008932684,
0.014830324,
0.024942536,
0.02422516,
-0.00837396,
0.023825087,
-0.019162158,
0.0014614767,
-0.027453344,
0.012009113,
0.0022004063,
0.0046663787,
-0.027522322,
-0.016168501,
-0.002321118,
-0.006746073,
0.020307196,
0.011650426,
0.018913835,
-0.0028091392,
0.008711953,
-0.020845227,
-0.0137335695,
0.037027523,
-0.017299745,
-0.0031816217,
0.0023331894,
0.00051302573,
0.032557733,
0.007842827,
-0.0069978433,
0.00017244562,
-0.02019683,
0.01341627,
0.0005677772,
0.02324567,
0.0076220967,
0.015575289,
-0.010933053,
0.044642724,
-0.0031505816,
0.006259776,
0.0076358924,
0.025287427,
0.0018744839,
0.009581079,
-0.006190798,
0.03250255,
0.046132654,
-0.019713983,
-0.02194888,
-0.014678571,
0.018058507,
-0.03857264,
0.000010164861,
0.0052113067,
0.018624127,
0.017023832,
0.016306458,
0.028239695,
0.016844489,
-0.0022538644,
0.020734861,
0.009587977,
0.008705055,
-0.0019520845,
0.012650611,
-0.0041248994,
0.0021762638,
-0.034875404,
0.004183531,
-0.0021969574,
-0.022597274,
-0.0029470958,
0.0057734796,
0.013071379,
-0.0054492815,
0.007525527,
-0.009518999,
0.03079189,
-0.0077945422,
-0.018099893,
-0.020969387,
0.017520476,
0.015161419,
0.0056976033,
0.004645685,
-0.010105314,
0.010808892,
-0.009560386,
-0.00009457565,
-0.0064460174,
0.014885507,
-0.012816159,
0.0018486171,
-0.007863521,
-0.0024918392,
0.0022849045,
-0.018817266,
0.010801994,
0.023935452,
0.005400997,
-0.028915683,
0.01465098,
-0.023825087,
0.058659103,
-0.006780562,
-0.00058114174,
-0.021686763,
-0.0021021122,
-0.012202253,
-0.0016563402,
-0.01351284,
-0.025632318,
0.018513761,
0.01550631,
-0.0006833158,
-0.019700188,
0.008132536,
0.045332506,
-0.007966988,
-0.0018313725,
-0.024335526,
-0.0011941859,
0.022224791,
0.016306458,
0.011602142,
-0.0048698643,
0.0011950482,
-0.010629549,
-0.019010406,
-0.009470713,
-0.026156552,
0.0002513395,
0.004683623,
-0.01528558,
0.012878239,
0.028722543,
0.021065958,
0.014181928,
0.018389601,
0.00089154387,
-0.036420517,
-0.002860873,
0.00073806726,
0.011091703,
-0.009988051,
0.004635338,
0.0371103,
0.00869126,
-0.014499228,
0.024073409,
0.003786906,
0.003983494,
-0.027191225,
-0.0058769467,
0.04649134,
0.0015511484,
0.02952269,
0.0050733504,
-0.0038869244,
0.040034976,
-0.006073535,
-0.0011355544,
-0.0023918208,
0.0074841403,
-0.024542462,
0.012678202,
-0.030515978,
-0.010677833,
0.0059631695,
0.015754633,
0.0057424395,
0.0042801006,
-0.0045525646,
0.020941796,
-0.019231137,
0.011615938,
-0.00021900595,
-0.0035730733,
-0.011967726,
-0.0104640005,
-0.004483586,
-0.019272523,
-0.022831801,
-0.018279236,
0.00074927625,
-0.0006281332,
-0.030819481,
-0.02422516,
-0.024376914,
-0.011809076,
0.00042615624,
-0.021328075,
0.021728149,
0.024708008,
-0.029439917,
-0.026335895,
0.006901274,
0.008670566,
-0.0051457775,
0.0266394,
-0.008456733,
-0.017258357,
0.00992597,
-0.027977578,
-0.015395945,
-0.01433368,
-0.028777726,
0.0062390827,
0.034406353,
-0.011043418,
-0.021603988,
-0.0033092315,
0.029991742,
-0.006242532,
0.027674073,
-0.0030798789,
-0.0077393595,
-0.009822503,
0.0063115098,
0.008974071,
-0.01452682,
-0.009746627,
-0.021576397,
0.006859887,
-0.020279605,
0.0008846461,
-0.019713983,
0.011595244,
0.006066637,
-0.008394653,
-0.0026453158,
0.013823241,
0.007808338,
-0.013802548,
-0.02737057,
0.015547697,
-0.014678571,
0.0017848122,
0.000926033,
0.011643529,
0.004483586,
-0.0017451497,
0.009794911,
-0.0069047227,
-0.0025573687,
0.018596536,
0.002562542,
-0.0056217276,
0.0320335,
0.00277465,
-0.013947402,
-0.042131916,
-0.02800517,
-0.0023280159,
0.015740836,
-0.015299376,
-0.021190118,
0.001893453,
-0.012788568,
-0.001991747,
0.017244563,
-0.018624127,
-0.010629549,
0.013747365,
-0.014664776,
0.00014722545,
0.013402474,
-0.028777726,
-0.018265441,
-0.017575659,
-0.018610332,
0.016416823,
0.020596905,
-0.020996979,
-0.006394284,
0.0030074518,
-0.018058507,
0.007760053,
-0.036668837,
-0.008746442,
0.0007048715,
0.043180384,
0.035040952,
0.026501443,
-0.011064111,
-0.009532794,
0.020348584,
-0.0074358555,
0.002305598,
0.0002925109,
-0.0018606883,
-0.022873187,
0.006001108,
-0.0028936376,
-0.004956087,
-0.010691629,
-0.015658062,
0.007808338,
0.015796019,
-0.0034558102,
-0.031509265,
0.010050131,
-0.031095395,
0.0054561794,
0.00085619255,
0.0051388796,
0.0364757,
-0.018182667,
0.0006988359,
0.04290447,
-0.017465293,
-0.004738806,
0.0053872014,
0.03733103,
0.025797866,
0.0011398656,
0.01528558,
0.024142388,
0.002547022,
-0.012236741,
-0.020679679,
-0.0030040029,
0.016085727,
0.010291555,
0.018637924,
0.02343881,
-0.031343717,
0.01560288,
0.005718297,
-0.003631705,
0.020541722,
-0.0063425503,
-0.010174292,
-0.020624496,
-0.016858283,
-0.024556257,
-0.02702568,
0.013788752,
-0.007046128,
-0.013933606,
0.020003693,
-0.016251275,
-0.005207858,
0.025039105,
-0.028722543,
0.040669575,
-0.006925416,
0.035758324,
0.00083851686,
-0.0033592407,
-0.023480196,
-0.024445891,
-0.00015886553,
-0.012257435,
0.009891481,
0.016513392,
-0.016058136,
-0.016513392,
0.0062528783,
0.014775141,
-0.011105498,
-0.05474114,
0.006139064,
0.013029992,
0.0021452236,
-0.030709118,
0.010808892,
-0.046739664,
0.008291186,
0.010395022,
-0.017989527,
-0.019479457,
-0.0042697536,
0.003904169,
0.046739664,
-0.003986943,
0.026239326,
0.020403767,
0.0035730733,
-0.006580525,
-0.022169609,
-0.011002031,
0.0073806727,
-0.009263779,
0.0033506185,
-0.014485433,
-0.008539507,
-0.0032023152,
0.03562037,
-0.010505388,
-0.002638418,
0.0015752908,
0.03015729,
0.0000123877935,
-0.009277575,
0.030129699,
0.011622835,
0.01633405,
0.025246039,
-0.013526635,
-0.013754263,
-0.021038366,
-0.008980968,
0.021935083,
-0.006549485,
0.013174846,
-0.007656586,
0.007849725,
-0.004497382,
-0.006708135,
0.0016166777,
0.015051054,
-0.029164003,
-0.021893697,
0.0043490785,
0.0070771687,
0.010098415,
0.018375807,
0.017782593,
-0.0075393226,
0.021328075,
-0.01963121,
0.020610701,
0.027011883,
0.016182298,
-0.050630037,
0.0041317972,
-0.023204284,
-0.015133828,
0.019796757,
0.019810554,
-0.027191225,
-0.02270764,
0.03264051,
0.04696039,
0.0057665817,
-0.015230398,
-0.00076781417,
0.012222946,
0.00006574489,
0.00026060845,
-0.03264051,
-0.0018675862,
-0.012271231,
-0.010857177,
0.0150648495,
-0.037634533,
0.016306458,
0.010029438,
-0.0019796758,
-0.0036558472,
-0.028888091,
0.004066268,
0.011277944,
-0.017354928,
0.0053458144,
0.016375437,
0.0012252262,
-0.014761345,
-0.006966803,
0.017051423,
-0.0003606269,
0.021686763,
0.009560386,
-0.0060528414,
0.0047905394,
-0.0030436653,
-0.011926339,
-0.007180636,
-0.019741574,
-0.03374416,
-0.051650915,
0.0011915993,
-0.030267656,
0.014885507,
0.008705055,
-0.03184036,
-0.033440657,
-0.010829586,
-0.014816528,
0.0013105867,
-0.020969387,
0.0023142202,
0.0096362615,
0.023204284,
-0.0050664525,
0.032088682,
-0.009174108,
0.016444415,
-0.017092811,
0.008580894,
0.006473609,
0.015437332,
0.018706901,
-0.012823056,
-0.042711332,
-0.018182667,
0.0047526015,
-0.0022521398,
-0.00033691563,
0.006666748,
0.035372045,
0.0016615136,
0.0009915624,
0.047870904,
0.00033820898,
0.009049946,
0.013926709,
-0.013402474,
0.009850094,
0.013588715,
-0.008898194,
0.013568021,
0.0045456667,
0.02365954,
-0.013216233,
-0.012167763,
-0.001814128,
-0.025770275,
0.019244932,
-0.013899118,
0.02143844,
0.034682263,
-0.0047457037,
0.032557733,
0.008153229,
0.011319331,
0.0012088438,
0.020596905,
-0.022404136,
-0.009429327,
0.014154337,
0.013292109,
0.0021590192,
-0.011208965,
0.000718236,
-0.017423905,
0.012698896,
-0.015271785,
-0.012698896,
-0.01782398,
0.02226618,
-0.012202253,
-0.0082429005,
-0.015092441,
0.013699081,
-0.025397792,
0.010822687,
0.0075807096,
0.016941058,
-0.043401115,
0.010353635,
0.0005350126,
-0.014126746,
-0.0023349137,
0.019162158,
0.0013726671,
0.0000016739351,
0.017492885,
0.18916595,
0.008636077,
0.011981522,
0.038931325,
-0.040172935,
-0.010698526,
0.019686393,
-0.011312433,
-0.0008863705,
0.027260205,
-0.00023948387,
0.024404505,
0.0059631695,
-0.004066268,
0.028308675,
0.013333496,
-0.025039105,
-0.02121771,
-0.016927263,
0.008332573,
0.026804948,
-0.013333496,
-0.01623748,
-0.008422244,
0.016761715,
-0.0012579908,
-0.00058933295,
-0.011981522,
0.020279605,
0.007463447,
0.005476873,
-0.0070392303,
0.002997105,
-0.0065253424,
-0.029550282,
-0.00061735534,
-0.0002875531,
0.00022956824,
-0.00818082,
0.009277575,
-0.028612178,
-0.03672402,
-0.0074979356,
-0.031316124,
0.006066637,
0.003031594,
0.010188088,
-0.0014951036,
-0.012491961,
0.018596536,
-0.009691444,
0.008636077,
0.0047767437,
0.021259097,
-0.015175215,
-0.0076772794,
0.012712692,
0.018596536,
-0.0051837154,
-0.004255958,
-0.005242347,
0.018844858,
-0.013788752,
0.016706532,
-0.01718938,
-0.0013011022,
0.003590318,
0.007139249,
0.006411528,
-0.022542093,
-0.000049443395,
0.017892959,
-0.03178518,
0.012657509,
-0.015878793,
-0.017023832,
0.03241978,
0.027067065,
0.0005121635,
0.025315018,
-0.011215864,
-0.0032833647,
-0.018886244,
0.02788101,
-0.020762453,
-0.020155445,
0.00859469,
-0.006773664,
-0.0043490785,
-0.019769166,
0.0034161478,
-0.024914945,
-0.008967172,
-0.0068495404,
0.021190118,
0.0038972711,
-0.008132536,
-0.0017322163,
-0.007222023,
-0.007573812,
-0.019934714,
0.058052097,
0.0020383073,
0.026294509,
0.0052733873,
-0.009043048,
-0.02844663,
-0.007359979,
0.01560288,
0.0036868874,
0.019865736,
-0.035399638,
0.004097308,
-0.011546959,
-0.004500831,
0.040504027,
-0.007132351,
-0.05727954,
0.043787394,
0.0074358555,
0.0007389295,
-0.030515978,
0.0051043904,
0.016168501,
-0.009463816,
-0.023963043,
-0.010505388,
-0.0020555519,
0.002879842,
-0.026915314,
0.011933237,
-0.016720328,
0.02610137,
0.0075393226,
0.004973332,
0.0037558656,
-0.00764279,
0.006304612,
-0.021590192,
0.007884214,
-0.012988605,
0.011181374,
0.022473114,
0.0031867952,
0.01887245,
0.007877316,
0.0047043166,
-0.0024659724,
-0.025135674,
-0.014513024,
-0.0096362615,
-0.0044318526,
0.010615753,
0.0048008864,
0.01667894,
-0.009719036,
0.012533348,
-0.02334224,
0.020790044,
0.007601403,
-0.023673335,
-0.008001477,
0.04309761,
0.00030134874,
0.0066150143,
-0.0107813,
-0.17713615,
0.007291001,
-0.0037420702,
-0.028474221,
0.009112027,
0.0015709796,
0.01890004,
0.025315018,
-0.0038800265,
-0.008442937,
0.021259097,
0.013174846,
-0.02038997,
0.004587054,
-0.0030264207,
-0.004176633,
-0.025383996,
0.016030544,
0.0071116574,
0.02121771,
0.020721067,
-0.014623389,
0.020638293,
0.0051078396,
0.014264702,
0.0015020014,
-0.005038861,
-0.010870973,
-0.029881379,
-0.013850832,
0.007822134,
-0.017975733,
0.0007397917,
-0.0014002585,
0.020224422,
-0.0046077473,
-0.024873557,
0.018527558,
-0.015561493,
0.0071944315,
-0.002490115,
0.0061252685,
-0.020431358,
-0.0025090838,
0.0009139618,
0.018858654,
0.00697715,
-0.028529404,
0.024307935,
-0.02397684,
0.0060390458,
-0.046353385,
0.011947033,
-0.0012485064,
0.016775511,
0.026984291,
0.003986943,
0.034902994,
0.009615568,
-0.03757935,
0.0034299435,
-0.0061976956,
0.016472006,
-0.034461536,
-0.0015511484,
-0.025494361,
-0.004259407,
0.0043973634,
-0.0109882355,
0.017548067,
0.02026581,
-0.014733754,
-0.011912543,
-0.02388027,
0.021410849,
-0.0010683007,
-0.020514132,
0.018265441,
0.0042801006,
-0.005166471,
-0.01230572,
0.012733385,
-0.005976965,
-0.006683992,
0.0005953685,
-0.019189749,
0.005028514,
0.0012640264,
-0.012898933,
-0.012416085,
0.017216971,
-0.014582002,
-0.007518629,
-0.014513024,
0.03390971,
0.007256512,
-0.02324567,
0.008505018,
0.014023278,
-0.021714354,
0.021603988,
-0.0019641556,
-0.0046870722,
0.015658062,
-0.018913835,
0.014416454,
-0.019962305,
-0.004362874,
0.024790782,
-0.015464923,
-0.026970496,
0.0056665633,
0.007725564,
0.0003095399,
-0.00017298452,
0.03161963,
-0.011609039,
-0.021866105,
-0.012457472,
-0.043401115,
0.02730159,
-0.021714354,
-0.010374329,
0.011898749,
0.012650611,
-0.006411528,
-0.115331635,
-0.012195354,
-0.019810554,
0.009877685,
0.010574366,
0.040255707,
0.0074703447,
0.024087206,
0.0027073964,
0.03206109,
-0.018472375,
-0.03860023,
-0.031067804,
-0.004728459,
0.017837776,
0.007090964,
-0.014347476,
-0.029991742,
-0.019438071,
0.033164743,
-0.006073535,
-0.009622466,
0.009194801,
-0.0076220967,
-0.014582002,
0.0077462574,
-0.024501074,
0.018182667,
0.030433204,
0.01093995,
0.00796009,
-0.022693845,
-0.012119479,
-0.008767135,
-0.023480196,
-0.005438935,
-0.012685101,
-0.036282558,
0.018099893,
-0.013981891,
0.0007169427,
0.021548806,
-0.0031764484,
-0.0065012,
0.017437702,
-0.007718666,
-0.015933976,
0.03865541,
0.0029729626,
-0.018844858,
-0.008843011,
-0.023204284,
-0.01994851,
0.003012625,
-0.0041421438,
0.017396314,
0.002365954,
0.012285027,
-0.0066012186,
-0.006863336,
-0.0134714525,
0.024376914,
-0.01855515,
0.010912359,
-0.013988789,
-0.014637184,
-0.02483217,
-0.0062045935,
0.00038239817,
-0.005918334,
0.009760423,
0.015120032,
-0.01877588,
0.0004906078,
-0.0013562848,
-0.010484694,
-0.036282558,
0.0036213582,
0.019231137,
-0.02644626,
-0.0023883719,
-0.015961567,
-0.0017417008,
-0.001432161,
0.022155814,
0.03951074,
0.013685285,
-0.028253492,
0.027439548,
-0.03126094,
0.015754633,
0.031481672,
-0.00418698,
-0.012333311,
-0.03349584,
-0.002860873,
0.005663114,
-0.008608486,
-0.022169609,
-0.0026435915,
-0.04160768,
0.00764279,
-0.059762757,
0.026308304,
0.027218817,
-0.0053389166,
0.0007829031,
-0.010050131,
0.017134197,
-0.033054378,
0.010926154,
0.003136786,
0.0006837469,
0.009877685,
-0.032557733,
-0.002403892,
-0.009456918,
-0.02312151,
0.021466032,
0.016927263,
0.038738184,
-0.0067288284,
-0.015216602,
0.0029660647,
0.041442133,
0.014250906,
-0.024307935,
0.01687208,
-0.015354559,
0.029357143,
-0.0028436284,
-0.0000024031242,
0.0027194675,
0.005728644,
0.0015390773,
0.025177062,
-0.021507418,
-0.011588346,
0.023218079,
0.017548067,
0.033164743,
0.028832909,
-0.012809261,
-0.005721746,
0.028694952,
0.008601588,
-0.00653224,
-0.0061425134,
-0.01589259,
0.006635708,
0.017906753,
-0.009587977,
0.0109675415,
0.0075393226,
0.013843935,
-0.021493623,
0.012443677,
-0.016044341,
0.0017511853,
0.01687208,
0.0008609348,
-0.019548437,
0.02375611,
0.014092256,
0.009332757,
0.010291555,
-0.003345445,
-0.0025418485,
-0.033551022,
-0.001311449,
-0.008408449,
-0.022997348,
-0.043345932,
-0.009243085,
0.021452235,
0.009505203,
0.029357143,
0.0093741445,
-0.009498305,
-0.0015476994,
0.013216233,
-0.00780144,
0.009174108,
-0.0063425503,
0.004842273,
0.016582372,
0.055679243,
-0.012347107,
-0.010339839,
0.010484694,
-0.011691813,
-0.007891112,
-0.011167578,
0.017216971,
-0.0012804088,
0.0056251762,
0.025370201,
0.021962674,
0.000048284775,
0.011843566,
0.02163158,
0.03352343,
-0.018513761,
0.0021452236,
0.0038489862,
-0.010670936,
-0.03396489,
0.027674073,
-0.038793366,
-0.020872818,
-0.008008375,
0.021452235,
-0.0053044274,
-0.009470713,
0.023149101,
0.017010037,
-0.025066696,
0.020693475,
0.009422429,
0.0005548438,
0.0034954727,
-0.003435117,
0.009732831,
0.01284375,
0.0038662308,
-0.011905646,
0.0036075625,
0.02143844,
0.020928001,
-0.009622466,
0.015478719,
-0.0027574056,
0.016223684,
-0.00069797365,
0.019272523,
-0.0021624682,
-0.016127115,
0.008518814,
-0.0009415531,
-0.012167763,
0.0018124036,
0.085477844,
0.006942661,
0.017892959,
0.003859333,
-0.0102018835,
0.018541353,
0.0071875337,
0.009077538,
0.0140163805,
-0.03352343,
0.007449651,
-0.0039179646,
-0.007566914,
-0.04240783,
0.0137335695,
-0.005687257,
-0.012478165,
0.028915683,
-0.029164003,
-0.020472744,
0.04522214,
-0.0044215056,
0.02480458,
0.012726487,
-0.015106237,
-0.0023297404,
0.017686022,
-0.003662745,
-0.005790724,
-0.031564448,
-0.01592018,
0.0260048,
-0.02280421,
-0.029798605,
-0.013726672,
-0.009029253,
-0.001504588,
-0.017699819,
-0.00015175215,
0.030957438,
-0.0067702155,
0.009236188,
-0.020500336,
-0.014719958,
-0.027080862,
0.007132351,
0.0027694767,
-0.025632318,
-0.016899671
] |
Skin dendritic cells (DCs) are thought to act as key initiators of local T cell immunity. Here we show that after skin infection with herpes simplex virus (HSV), cytotoxic T lymphocyte (CTL) activation required MHC class I-restricted presentation by nonmigratory CD8(+) DCs rather than skin-derived DCs. Despite a lack of direct presentation by migratory DCs, blocking their egress from infected skin substantially inhibited class I-restricted presentation and HSV-specific CTL responses. These results support the argument for initial transport of antigen by migrating DCs, followed by its transfer to the lymphoid-resident | [
-0.007859261,
0.023775915,
-0.00084371475,
-0.03648282,
-0.006152018,
0.026523354,
-0.028795274,
0.0021398324,
0.0030033602,
-0.025902538,
0.014159878,
0.0042169224,
-0.009642454,
0.00775359,
-0.021411533,
0.012488959,
0.030750183,
0.0026764416,
-0.014331593,
0.0035267607,
-0.041449346,
0.0050655906,
0.0094113,
-0.030512424,
-0.0065284697,
0.016273292,
0.008539516,
-0.038358476,
-0.02677432,
-0.0062279687,
0.013856075,
-0.0063006175,
0.010600096,
0.0010913805,
0.006422799,
-0.018439543,
0.036773413,
-0.023657035,
0.008414032,
0.018981105,
0.0010963338,
0.0043258956,
0.0037248933,
-0.018030068,
0.034131646,
0.012165342,
-0.009523574,
-0.024026882,
-0.006594514,
0.01915282,
0.03534686,
-0.005887841,
0.005934072,
0.002116717,
-0.028742438,
-0.0038701906,
0.008466868,
-0.0006055428,
0.010514238,
-0.03466,
-0.0032642349,
0.017647011,
-0.008797089,
0.0020853458,
0.01913961,
0.020222737,
-0.0026681859,
0.020896386,
-0.0014488448,
0.013829657,
0.01156434,
0.027395137,
-0.023313604,
-0.00089242234,
0.029825564,
-0.011788891,
0.0065053543,
0.00034941515,
0.005042475,
0.0021926677,
0.011187889,
-0.02518926,
-0.018650884,
0.029508552,
0.005144844,
0.008645187,
0.01032271,
0.002134879,
-0.0064294036,
-0.004382033,
0.006762927,
0.0024139157,
0.005075497,
0.026959246,
0.003992372,
0.008057393,
0.011716242,
0.020103857,
-0.0028679697,
-0.014939199,
-0.0034309966,
0.0023792426,
-0.018532004,
-0.024581654,
-0.033339117,
-0.0059307697,
0.0068818065,
0.010553864,
0.02861035,
-0.00787247,
-0.015269421,
0.0030495913,
-0.0049698264,
-0.053601477,
0.0106463265,
0.017422462,
0.008004558,
0.010289688,
-0.016471425,
-0.008169669,
0.015229794,
0.020830343,
0.0044711926,
-0.020803925,
0.036773413,
-0.000048862395,
-0.004804716,
-0.002295036,
-0.008519703,
-0.011168076,
0.02199272,
0.008057393,
0.0072120274,
-0.01128035,
0.016616723,
0.0032213063,
-0.022190854,
0.01903394,
-0.0075686662,
-0.0041872025,
0.0047023473,
0.048265107,
0.013856075,
-0.000020819405,
0.017369626,
0.026972454,
0.029112287,
0.021292653,
-0.011947397,
-0.0069940817,
-0.0028068789,
-0.03592805,
0.010474611,
-0.02381554,
-0.0037645197,
0.023168309,
-0.00044951338,
0.027897073,
0.01048782,
-0.013089961,
0.002981896,
-0.027315885,
0.030723765,
-0.016828064,
0.011326581,
0.033074938,
0.0054882737,
0.011630385,
0.014265548,
0.008268734,
-0.0048113205,
0.02200593,
-0.02291734,
0.023590991,
-0.021002058,
0.012805971,
-0.0035696893,
0.011333186,
-0.017488506,
-0.037460275,
-0.008288548,
0.008090415,
0.028055578,
-0.013321117,
0.0031618665,
-0.004504215,
0.010989756,
-0.015969489,
-0.018162157,
-0.021649292,
-0.019747218,
0.013816448,
-0.0054057185,
-0.02551948,
-0.6255707,
-0.030089742,
0.03650924,
-0.0034012767,
0.0040716254,
0.027659314,
0.014265548,
-0.005144844,
-0.0040881364,
0.014635396,
0.0036159204,
0.00049037824,
0.0035102495,
-0.011577549,
-0.019628339,
-0.024317477,
-0.00339137,
0.006343546,
0.016920526,
0.0004408451,
-0.013393765,
-0.023115473,
0.010580282,
0.015031662,
-0.020117065,
0.0053462787,
0.029059451,
0.0023511737,
0.0063963817,
0.027078126,
-0.035980884,
0.009279211,
-0.012455937,
-0.010910503,
0.053363718,
0.016616723,
-0.01219176,
0.021636082,
0.0042763622,
0.040630396,
-0.023921212,
-0.0058151926,
0.00741016,
0.019232074,
-0.024251433,
0.016141204,
-0.023643825,
0.015163749,
0.014714649,
-0.005428834,
0.00640959,
0.002747439,
-0.022164436,
0.009490552,
0.029825564,
0.0047816006,
0.015044871,
-0.014093834,
0.008222504,
0.013466414,
0.0074497866,
0.019403787,
-0.0008057393,
-0.015863819,
-0.0014298571,
-0.0085461205,
-0.01674881,
0.008909363,
0.024594862,
-0.017131867,
0.003014918,
0.020341616,
-0.0136315245,
0.00060636835,
-0.00075331674,
0.016590305,
-0.0015437833,
-0.008915968,
-0.0073969513,
0.021530412,
-0.0069610593,
-0.018743346,
-0.012693697,
0.0010319407,
-0.010626513,
-0.035373278,
-0.013803239,
0.026879992,
-0.019786844,
0.016669558,
0.010124577,
0.034131646,
-0.0100387195,
-0.032440916,
-0.026140297,
0.029693475,
-0.0049103866,
-0.012178551,
-0.0188226,
-0.002856412,
-0.008909363,
-0.005412323,
0.015784565,
-0.0018954687,
0.025453437,
-0.00013177883,
-0.042083368,
0.018030068,
0.049744498,
-0.057326373,
0.009345255,
-0.00066044205,
-0.00980096,
0.011491692,
0.0052670254,
-0.00872444,
0.014027789,
0.014463682,
0.0056632906,
-0.0225607,
0.014886364,
0.006482239,
-0.0136315245,
-0.036562074,
0.01367115,
0.0063600573,
-0.020909596,
-0.0122512,
0.0059307697,
-0.015044871,
-0.004533935,
-0.019232074,
0.022877714,
-0.028425427,
0.03553178,
0.009602828,
0.027500808,
-0.0059241652,
-0.012224782,
-0.033656128,
-0.032757927,
-0.00024456996,
-0.011445461,
-0.008797089,
-0.0007062602,
-0.0011012872,
-0.0079517225,
-0.00021485006,
-0.0021728545,
-0.024026882,
0.019205656,
-0.016101578,
0.0061189956,
-0.015190167,
0.018162157,
-0.0066341404,
0.019562295,
-0.0010311152,
0.019284908,
-0.01390891,
-0.0041839005,
0.023974048,
0.00032279105,
0.02781782,
-0.012211574,
0.000021386972,
0.0058779344,
0.012667279,
0.005980303,
-0.04002279,
-0.014754276,
-0.008143251,
-0.008460263,
0.00809702,
0.0009295722,
-0.014305175,
-0.01247575,
-0.014714649,
-0.023155099,
0.0145429345,
-0.0014389382,
-0.024687324,
0.023643825,
-0.0008338081,
0.029217957,
-0.007588479,
0.019007523,
-0.0016709184,
0.0026136995,
0.035161935,
-0.00073804404,
0.01287862,
-0.010745392,
0.0031651687,
0.0027276257,
-0.010197226,
0.026047835,
0.037037592,
0.003029778,
0.022058764,
-0.01413346,
-0.02575724,
0.010434984,
-0.0013522551,
0.02348532,
-0.020592583,
-0.0063501503,
-0.029455716,
0.02861035,
0.014397637,
0.015520388,
-0.009001825,
-0.0077469856,
0.012898434,
0.007588479,
0.013578689,
-0.009668872,
-0.0018343779,
-0.002605444,
-0.020949222,
-0.009807564,
-0.010111368,
0.021160563,
-0.012931456,
-0.0139353275,
0.024264641,
0.020922804,
0.0004821227,
-0.00020618176,
-0.01813574,
-0.01629971,
-0.010421776,
0.008189482,
0.030195411,
0.002400707,
0.01247575,
0.02418539,
0.012416311,
0.023221143,
-0.0033550458,
0.0020985547,
0.024766577,
-0.0039032127,
0.0030578468,
0.0059076543,
-0.004269758,
0.011914375,
-0.017607385,
-0.016326128,
0.016669558,
-0.00084866805,
-0.015176958,
-0.00081027986,
-0.014054207,
0.008110229,
-0.0024040092,
0.008222504,
0.013882493,
0.022613537,
0.02530814,
0.004286269,
-0.009490552,
0.020685045,
-0.035663873,
0.0038470752,
0.0075554573,
-0.02871602,
-0.007925305,
-0.022507865,
0.01099636,
-0.018082904,
0.0139485365,
0.0070865434,
-0.023313604,
0.0021860632,
0.024687324,
-0.013697568,
-0.005914259,
-0.004005581,
0.007925305,
-0.024581654,
-0.025704406,
0.0037546132,
0.006422799,
-0.01071237,
-0.018796181,
-0.01858484,
0.001396835,
-0.004547144,
0.011333186,
-0.002243852,
0.009649059,
0.0005985256,
-0.013017314,
-0.0026632326,
-0.0013877539,
0.027949909,
0.0027424856,
0.0103359185,
0.013486227,
0.0014859947,
-0.008863132,
-0.016735602,
-0.025374183,
0.03727535,
0.004236736,
0.0027821122,
-0.028583933,
-0.011471879,
-0.010236852,
0.0037612177,
0.0038999105,
-0.020051021,
-0.0115445275,
0.018201783,
0.01237008,
0.0052538165,
0.02291734,
0.014529726,
0.013473018,
-0.019918934,
-0.053046707,
-0.013895701,
-0.03249375,
0.028081996,
0.009622641,
-0.018743346,
0.01776589,
0.013552271,
-0.011597362,
-0.0085527245,
-0.0103557315,
0.030961525,
-0.026232759,
-0.011352999,
-0.00458677,
-0.020883178,
-0.0013324419,
0.03146346,
0.03262584,
0.0038404707,
0.015348674,
-0.008691418,
-0.0047948095,
-0.0031337976,
-0.00025220632,
0.03909817,
0.035373278,
0.019456623,
0.0015677244,
0.008030975,
0.021068102,
0.011425648,
-0.015758147,
-0.005399114,
0.020011395,
0.017699847,
0.025004337,
-0.0035498762,
-0.02451561,
-0.01858484,
0.013988163,
0.0036489423,
-0.0007347418,
0.027078126,
0.02861035,
0.013737195,
-0.0051217284,
0.011815309,
-0.0047849026,
0.025387393,
0.0076215016,
0.007192214,
-0.033550456,
0.032308824,
-0.014952408,
-0.0037645197,
-0.0154411355,
-0.009563201,
-0.004817925,
-0.010104763,
0.0005799507,
-0.007846052,
-0.0028399008,
-0.026959246,
-0.013974954,
0.001136786,
-0.0073110936,
-0.045808263,
0.009827378,
-0.022785252,
0.0066176294,
-0.029904816,
-0.018650884,
0.0026913015,
-0.020196319,
-0.022494657,
0.006105787,
-0.007727172,
-0.0034607165,
0.010164203,
-0.009239584,
0.01891506,
0.03273151,
-0.009833982,
-0.008004558,
0.0031007754,
-0.020354824,
0.016088368,
0.015995907,
-0.009668872,
0.006297315,
-0.019232074,
0.0032840483,
0.0019383975,
0.011445461,
-0.012951269,
-0.021821005,
-0.006201551,
0.017924398,
0.01891506,
0.03524119,
-0.021345487,
-0.021200191,
-0.01845275,
-0.044091113,
-0.0039857677,
-0.008929177,
-0.0008742602,
-0.02861035,
0.004144274,
0.014186296,
0.010078346,
-0.005045777,
0.03487134,
-0.029693475,
-0.0064161946,
-0.026879992,
0.010468007,
0.019430205,
0.0076215016,
0.019113194,
0.0066803717,
-0.018399917,
-0.008988617,
-0.013208841,
0.016577097,
-0.0030958222,
-0.022851296,
0.011736056,
0.0072450493,
-0.009583014,
-0.012244596,
-0.027104542,
-0.010600096,
-0.00077271723,
0.008717835,
-0.010811437,
-0.020486914,
0.006719998,
0.0033005592,
0.012224782,
0.012277618,
-0.009114101,
-0.005148146,
0.018518796,
-0.016669558,
-0.026721487,
0.026734695,
-0.03325986,
-0.0129975,
0.02781782,
0.010811437,
0.008770671,
0.015361883,
-0.006650652,
-0.011260537,
-0.014582561,
-0.0025691197,
-0.03603372,
0.0014108694,
-0.015282629,
0.038094297,
0.01834708,
0.039520852,
-0.013070148,
0.017092241,
0.015995907,
0.007892283,
-0.00058738067,
-0.009285815,
0.032995686,
-0.019641547,
0.006624234,
-0.023194725,
-0.018228201,
0.021530412,
0.0045438414,
0.021741753,
0.014965617,
-0.007760194,
-0.027421555,
0.005742544,
-0.025096798,
-0.016405381,
0.0031965396,
-0.003843773,
0.005200981,
-0.035188355,
-0.0034706232,
0.02394763,
-0.006327035,
-0.007674337,
-0.0010195575,
0.033576876,
-0.015586433,
0.008394219,
-0.010177412,
-0.012706906,
-0.00797814,
0.0015091101,
0.002009395,
0.008896154,
0.009470739,
0.005286839,
-0.018782973,
0.022375777,
0.0040253946,
0.019932142,
0.0050523817,
-0.0142259225,
-0.032097485,
-0.029191539,
-0.012112508,
-0.015612851,
-0.030327499,
-0.030089742,
-0.016709184,
-0.007192214,
-0.011135053,
0.00094690884,
0.017607385,
-0.012627652,
-0.021873841,
0.03796221,
0.0024865645,
0.016458217,
-0.037803706,
0.03637715,
0.02657619,
-0.015493971,
-0.022071974,
0.0016791739,
-0.0133343255,
-0.0052240966,
0.03864907,
0.029217957,
0.013723986,
-0.015414718,
-0.00079996046,
-0.0024700533,
0.005996814,
-0.021821005,
0.017237538,
0.026232759,
-0.0055212956,
-0.0164318,
-0.031648383,
-0.03666774,
0.0106331175,
-0.011874748,
0.0056731976,
0.004022092,
-0.009081079,
-0.01845275,
0.022758834,
-0.005868028,
0.01789798,
-0.0022388985,
-0.016537469,
-0.023974048,
-0.03500343,
0.0020341615,
0.00075084006,
-0.000076827986,
-0.0058911433,
0.012885225,
0.011128449,
0.028187668,
0.009523574,
0.0008057393,
-0.0015124123,
-0.007898887,
0.049057636,
-0.01089069,
-0.0045603523,
0.014318384,
-0.009682081,
0.009933049,
-0.0124427285,
0.01014439,
0.00917354,
-0.036086556,
-0.026061043,
0.031621967,
-0.002777159,
-0.002826692,
0.011630385,
-0.020883178,
-0.0063666617,
-0.0216625,
-0.020724673,
0.014925991,
-0.033339117,
-0.0053198608,
0.008044184,
0.0072252364,
0.019179238,
-0.009497157,
0.008882945,
-0.004147576,
0.020936014,
-0.03236166,
0.028240504,
0.009867004,
0.028795274,
-0.02781782,
0.0048146225,
0.0030198714,
-0.04147576,
0.009675477,
-0.0046396055,
-0.04913689,
-0.032995686,
-0.0016139554,
-0.011914375,
-0.0036786622,
-0.02279846,
0.00521419,
0.0049797334,
0.027183795,
-0.0017980535,
-0.008414032,
0.030961525,
-0.023657035,
-0.03738102,
0.0035862005,
-0.030697348,
-0.013539063,
-0.0035729916,
0.0075950837,
0.0027606478,
-0.03524119,
-0.014635396,
-0.01562606,
-0.005164657,
-0.003503645,
-0.017739475,
0.006733207,
0.00039482053,
-0.011485088,
-0.0035696893,
0.01470144,
-0.01733,
-0.011861539,
-0.010349127,
-0.0015272723,
0.027395137,
-0.014159878,
0.00906787,
-0.0038833993,
-0.036879085,
-0.027157377,
-0.0023462204,
-0.019113194,
0.042215455,
0.010137786,
0.01083125,
-0.006921433,
-0.0063699638,
-0.06873881,
-0.014239131,
0.015282629,
-0.005290141,
0.010078346,
0.01937737,
-0.0041013453,
-0.017118659,
0.0049533155,
0.020315198,
0.000023450853,
-0.012383289,
0.022785252,
0.007192214,
0.02633843,
0.01026327,
-0.014978826,
-0.01550718,
0.023273978,
0.014833529,
0.010005698,
0.0042994777,
-0.017039405,
0.006736509,
-0.022098392,
0.010448193,
-0.0047353697,
0.0041376697,
-0.010593491,
-0.019245282,
0.007145983,
-0.0064261016,
-0.016590305,
-0.0065284697,
-0.024198597,
0.0011012872,
0.011491692,
0.000835872,
0.005541109,
-0.021913467,
0.0201699,
-0.03304852,
0.018148948,
0.01595628,
-0.008856528,
0.0070403125,
0.0060034185,
-0.0079583265,
-0.001302722,
-0.006531772,
-0.024779787,
-0.027078126,
-0.0057887747,
-0.008110229,
-0.004269758,
0.004431566,
0.014318384,
-0.039890703,
0.017396044,
-0.00073886954,
0.014410846,
-0.030089742,
0.027315885,
0.002090299,
-0.021279443,
-0.005415625,
0.0016568841,
-0.016352545,
-0.024925083,
0.008017766,
0.013618316,
0.007925305,
-0.006142111,
-0.011452066,
-0.007489413,
-0.008737649,
-0.029719893,
-0.019245282,
-0.01833387,
-0.000072493836,
0.19316609,
-0.005696313,
-0.012581421,
0.004164087,
-0.009100892,
0.0004055527,
0.015692104,
0.0026549771,
0.0034442055,
-0.002607095,
0.024145762,
-0.011121845,
0.018756555,
-0.00085279584,
0.00706673,
-0.0048377384,
-0.011868144,
-0.009530179,
-0.009021639,
-0.034712836,
0.017514924,
-0.0044645886,
-0.001946653,
0.002828343,
0.036429986,
0.0018079602,
-0.020381242,
0.031093612,
0.0016973361,
0.0034475075,
-0.022455031,
0.016260084,
-0.0018112623,
0.0015413067,
0.014886364,
-0.005636873,
-0.020473704,
-0.0009617688,
0.01253519,
0.0074167643,
0.001883911,
-0.016392171,
-0.033788215,
0.0075752707,
-0.018399917,
0.02532135,
0.019707592,
-0.017541341,
-0.0058515165,
0.0006575526,
-0.034712836,
-0.015771357,
0.0073837424,
0.007852656,
-0.00524391,
-0.011148262,
0.03864907,
0.02393442,
-0.010910503,
0.01573173,
-0.033920303,
0.00997928,
-0.021596456,
0.04298157,
0.018360289,
0.016352545,
-0.016392171,
0.007060126,
0.013433391,
-0.012792763,
0.015454344,
0.0066341404,
-0.030697348,
0.003936235,
-0.01903394,
-0.02097564,
0.012343662,
-0.0047650896,
0.024211807,
0.011736056,
0.011386021,
-0.00521419,
-0.0055345045,
0.014767485,
0.0026747903,
-0.03806788,
0.030538842,
0.012772949,
-0.03431657,
-0.0041244607,
0.00935186,
-0.011577549,
-0.007588479,
-0.009345255,
0.0168809,
0.0039956747,
0.00458677,
0.009305629,
0.024475982,
-0.0052042836,
-0.0394416,
0.07354683,
0.033603292,
-0.0013984861,
0.009081079,
0.022983383,
0.0069016195,
-0.009483948,
-0.0049830354,
-0.026734695,
0.027210213,
-0.015176958,
0.009682081,
0.0021431346,
-0.0321239,
0.020447286,
0.008744253,
-0.016392171,
0.020460496,
0.001727056,
0.018558422,
-0.026998872,
0.004289571,
0.028663186,
0.007251654,
0.003500343,
-0.045174237,
0.008460263,
0.02212481,
-0.04472514,
-0.002650024,
-0.0031816796,
-0.0022388985,
0.02758006,
0.011861539,
-0.016695976,
0.020222737,
-0.027289467,
-0.012099299,
0.016009117,
-0.010197226,
-0.004444775,
0.01824141,
0.0017864958,
-0.005699615,
-0.008856528,
0.02349853,
0.030327499,
-0.01698657,
-0.027897073,
0.0106463265,
-0.03112003,
-0.018505586,
-0.01573173,
0.006875202,
-0.03513552,
-0.019760426,
-0.0061289025,
-0.0047816006,
0.018096114,
-0.004378731,
0.019469833,
-0.0013720684,
-0.02771215,
-0.011960606,
-0.013737195,
-0.16421232,
0.00051473203,
0.014080625,
-0.020486914,
0.027553644,
0.014608978,
-0.0033979744,
0.0018657489,
-0.01788477,
0.022653162,
0.031225702,
0.012614444,
-0.033814635,
-0.012264409,
0.004791507,
-0.0067464155,
-0.012304036,
0.021715336,
0.032995686,
0.001505808,
0.037354603,
-0.017990442,
0.005795379,
-0.036086556,
0.010401962,
0.0240533,
-0.008394219,
-0.020051021,
-0.014054207,
-0.015863819,
-0.00061999,
0.014120252,
0.013089961,
-0.0066638603,
0.0385434,
-0.003843773,
-0.0028134831,
-0.0001446781,
0.012204969,
0.038147133,
0.030908689,
-0.0025212376,
0.016603513,
-0.011736056,
-0.013974954,
0.015190167,
-0.030855853,
-0.0035267607,
0.010375545,
-0.02006423,
0.024040092,
0.003282397,
0.0106463265,
0.025466647,
0.017396044,
0.007046917,
0.015718522,
0.010170808,
0.007515831,
0.0069148284,
0.005887841,
-0.028980197,
0.019456623,
0.0024750067,
0.005197679,
-0.044434544,
-0.0028663187,
0.031516295,
-0.019496249,
0.009497157,
-0.016207248,
-0.009728312,
0.014595769,
-0.018835807,
-0.0016725695,
0.020843552,
-0.009259398,
0.011597362,
0.008777275,
-0.0063303374,
-0.008665,
0.010071741,
-0.020447286,
0.00609588,
-0.024885457,
0.017686639,
-0.0079451185,
0.012277618,
0.029482134,
-0.003923026,
-0.006284106,
-0.030512424,
-0.0018905154,
-0.004335802,
0.015995907,
0.043140076,
-0.010969942,
-0.0058052856,
-0.023841958,
0.020632211,
0.0049235956,
0.0022801762,
-0.018901853,
0.006875202,
-0.028002745,
0.0039461413,
-0.019403787,
0.01247575,
0.025136424,
-0.010910503,
-0.00888955,
0.002872923,
0.030459588,
0.011135053,
-0.0075224354,
0.0074497866,
0.009992489,
-0.016841272,
0.0059902095,
-0.018941479,
0.061606035,
0.0036192224,
-0.01857163,
0.009391487,
-0.010078346,
-0.01719791,
-0.14498024,
-0.009160331,
0.013261677,
-0.011425648,
-0.023960838,
0.023326814,
-0.0019251886,
0.009199958,
-0.016022325,
0.0000054918596,
-0.0020209528,
0.00007708597,
0.018069696,
-0.015427927,
0.012178551,
-0.0044645886,
0.007971535,
0.018941479,
-0.016788438,
0.033391953,
0.0065548876,
-0.0051514483,
-0.015678896,
-0.002134879,
0.016233666,
0.0032147018,
-0.044064693,
0.027157377,
0.014159878,
0.03270509,
0.0048542493,
-0.010666139,
0.035663873,
0.012528586,
-0.021953095,
0.0063996837,
-0.018281037,
-0.011135053,
0.036324315,
-0.006848784,
-0.0010707417,
0.017105449,
0.00057912513,
0.000077808334,
-0.0027507413,
-0.005399114,
-0.020790717,
-0.0017105449,
0.034184482,
-0.0023313605,
-0.019192446,
-0.041581433,
-0.041555014,
0.0003533365,
-0.0000023138045,
-0.010573678,
0.00646903,
0.022705998,
-0.007997953,
-0.01824141,
0.0085461205,
-0.003359999,
-0.019734008,
0.01801686,
0.03146346,
-0.012290827,
-0.025176052,
-0.0016667907,
0.020936014,
-0.031172866,
0.003530063,
-0.033788215,
-0.020473704,
0.000018510436,
-0.013816448,
0.008651791,
-0.0024617978,
0.00083463365,
-0.010316106,
-0.021609664,
-0.022904132,
-0.005696313,
0.022151226,
0.003880097,
0.043932606,
-0.0040286966,
-0.0038404707,
0.0018310756,
0.004986338,
-0.0042565493,
0.011386021,
0.03648282,
-0.0015198423,
-0.015348674,
0.0059241652,
0.010197226,
-0.0047353697,
0.014397637,
0.039890703,
0.034369405,
-0.00906787,
-0.0048806667,
-0.05679802,
0.010269874,
-0.018716928,
-0.0024584956,
0.021873841,
-0.014054207,
-0.009754729,
-0.017528132,
0.019179238,
0.01401458,
-0.0094113,
-0.006343546,
-0.030987943,
0.05516012,
-0.037037592,
-0.034607165,
0.018492378,
-0.023590991,
0.016048742,
0.019681174,
-0.0058746324,
-0.039256677,
0.0012061324,
0.007760194,
-0.008486681,
0.025836494,
0.009133914,
0.042400382,
-0.0046230946,
0.009358464,
0.0023065938,
-0.034607165,
-0.006650652,
0.018056486,
-0.009074474,
-0.0044414727,
0.0039626523,
0.025915748,
0.010150994,
0.026959246,
-0.03283718,
-0.038094297,
0.0021612968,
-0.011584154,
-0.045068566,
-0.00401879,
-0.03439582,
0.0032840483,
-0.0057623573,
-0.025823286,
0.041528597,
0.008882945,
0.00038512028,
-0.036773413,
-0.0011532969,
0.020209527,
0.0028762252,
-0.015018453,
-0.01606195,
-0.015863819,
0.011207702,
0.028557515,
0.023736289,
0.0067299046,
0.009398091,
-0.011069009,
-0.034290154,
0.011022778,
-0.011201098,
0.018756555,
-0.019998185,
0.020328406,
-0.004193807,
-0.008651791,
0.0100585325,
0.001789798,
-0.01618083,
-0.011168076,
-0.015071288,
0.02520247,
-0.0006352627,
0.00008209088,
-0.019615129,
0.0058911433,
0.027606478,
0.0075092264,
0.0082489215,
0.01903394,
-0.0044678906,
-0.0010814739,
0.005055684,
0.0037777286,
0.045993187,
-0.0037248933,
0.02075109,
0.014714649,
0.020605793,
0.020777507,
0.024264641,
0.028663186,
-0.0017567759,
0.013307908,
0.025479855,
-0.02073788,
0.0020358127,
0.03772445,
-0.019879306,
-0.03658849,
-0.014027789,
-0.0061487155,
-0.007661128,
0.0065879095,
0.013083357,
-0.001976373,
-0.03497701,
-0.0012317245,
0.01925849,
0.013697568,
-0.025730822,
0.008678209,
0.0040452075,
0.022758834,
-0.017475298,
-0.006198249,
0.0073969513,
-0.0046098856,
0.040075626,
-0.0142523395,
0.024885457,
0.0042631538,
0.007601688,
-0.014516517,
-0.0264441,
0.0006633315,
0.00084866805,
-0.018439543,
0.012700301,
0.03553178,
-0.020354824,
0.06271558,
0.017145077,
-0.021530412,
-0.0010542306,
-0.035743125,
0.013373952,
0.026629025,
0.02656298,
0.007562062,
-0.019337744,
0.024462774,
-0.012337058,
0.03830564,
-0.043615595,
-0.033365533,
0.030089742,
-0.022098392,
-0.0001498378,
0.008658395,
-0.0024436356,
0.022507865,
-0.004491006,
0.010593491,
0.026417682,
-0.019707592,
-0.020922804,
0.006353453,
-0.013882493,
-0.0014637047,
-0.027738567,
0.019918934,
-0.0057887747,
-0.036403567,
-0.016695976,
-0.010923712,
-0.024000464,
-0.015560015,
-0.019562295,
0.0045735613,
0.02154362,
-0.014344802,
0.021503994,
-0.013710777,
-0.014424055,
0.001121926,
-0.005276932,
-0.019575503,
-0.019469833,
0.0032840483
] |
Megakaryocytes undergo a unique differentiation program, becoming polyploid through repeated cycles of DNA synthesis without concomitant cell division. However, the mechanism underlying this polyploidization remains totally unknown. It has been postulated that polyploidization is due to a skipping of mitosis after each round of DNA replication. We carried out immunohistochemical studies on mouse bone marrow megakaryocytes during thrombopoietin- induced polyploidization and found that during this process megakaryocytes indeed enter mitosis and progress through normal prophase, prometaphase, metaphase, and up to anaph | [
-0.024374194,
-0.021420918,
-0.008028009,
-0.03417546,
-0.04304818,
0.02700506,
-0.0053391093,
0.0067899544,
-0.02353593,
-0.0068608844,
0.029145863,
-0.009504646,
0.007525049,
-0.017990477,
-0.021614365,
0.0034368904,
0.033659603,
-0.00866638,
-0.011013525,
-0.0041913297,
-0.019641217,
0.038663406,
0.022736352,
-0.014727688,
0.012445025,
0.018635297,
0.0032337722,
-0.028217321,
-0.013193017,
0.004294501,
0.0007580665,
-0.001292058,
-0.0054132636,
-0.010826527,
-0.022826627,
-0.027520915,
0.0070801233,
-0.0014629352,
0.0056357263,
-0.013109189,
-0.013012467,
-0.0043138457,
-0.005239162,
-0.014830859,
-0.0144181745,
-0.0029500513,
-0.0144697605,
-0.00049892947,
-0.011639,
0.010039846,
0.03559406,
-0.018751364,
0.011548726,
0.026463412,
-0.03412387,
-0.024632122,
0.0026582703,
0.0060258424,
-0.008356866,
-0.007525049,
0.013083397,
-0.009085514,
-0.0042461394,
-0.0077442876,
-0.009298304,
-0.0054777456,
-0.01368308,
-0.0145213455,
0.005684088,
-0.023342483,
0.04384776,
0.014805066,
-0.019550942,
-0.031750936,
0.0032369962,
-0.03291161,
-0.023032969,
-0.0017039367,
-0.011381072,
0.011535829,
0.03105453,
-0.0096400585,
-0.01221289,
0.024051785,
-0.0077055986,
0.0043847756,
-0.007692702,
0.019744387,
0.026669754,
0.008601898,
0.033298504,
0.039024506,
0.030383917,
0.022336563,
-0.005651847,
-0.0016765319,
0.005271403,
0.024696605,
-0.007860355,
-0.02087927,
-0.026166795,
0.007202639,
0.010381602,
-0.022362357,
-0.04647862,
0.015991535,
0.009917331,
0.0035400616,
0.02589597,
-0.005613158,
-0.006622301,
0.041423235,
0.0047007375,
-0.05251414,
0.024683708,
-0.016455805,
-0.01866109,
0.012483714,
-0.017500414,
-0.007654013,
0.023690686,
0.022749249,
0.026618168,
-0.005042492,
0.023909925,
0.020492379,
-0.015630435,
0.0020440794,
-0.015733607,
0.00013279261,
0.019280117,
0.0010147854,
-0.0081376275,
0.011535829,
-0.016958766,
-0.015991535,
-0.011871136,
-0.0052101454,
-0.012522404,
-0.039488774,
-0.0044395854,
0.028578421,
0.004620135,
-0.010568599,
0.01672663,
0.010504117,
-0.00020150623,
0.020608446,
0.008737311,
-0.012270924,
-0.014198936,
-0.014134454,
0.023071658,
-0.017822824,
0.0034336664,
0.023497239,
0.013631494,
0.0022455854,
-0.024335505,
0.015682021,
0.019228531,
-0.010407394,
0.018712675,
0.003972091,
0.007099468,
0.03022916,
-0.015862571,
-0.0008277876,
0.004671721,
-0.042042263,
-0.017178005,
0.009317649,
-0.053029995,
0.018209716,
-0.008008664,
0.01884164,
0.0021198457,
-0.0042848284,
-0.024812672,
-0.019950729,
0.0011373012,
0.015862571,
0.010549255,
0.0039946595,
-0.027082438,
-0.00135654,
0.026282862,
-0.033350088,
0.0029194225,
0.009917331,
0.0026099088,
0.009285407,
0.014121558,
-0.007467015,
-0.623154,
-0.019293014,
0.01701035,
-0.024258127,
0.016855594,
0.03559406,
0.013231706,
-0.009943124,
-0.020982442,
-0.0014766377,
-0.009543335,
0.01267716,
0.027856223,
-0.021472504,
-0.021034027,
-0.035310343,
0.0030951358,
-0.016249463,
0.006306339,
0.0027034078,
-0.022878213,
-0.016210774,
-0.0023729375,
0.021008234,
-0.012993122,
-0.015269337,
0.051662974,
0.004913528,
-0.017461725,
0.057569526,
-0.017500414,
0.004291277,
-0.030590259,
-0.008563209,
0.03144142,
0.026618168,
-0.006296667,
0.02009259,
-0.0001373265,
0.01773255,
-0.0007951436,
0.011722827,
0.020427896,
0.007860355,
-0.005555124,
0.00755729,
-0.0007697538,
0.003227324,
0.0076991506,
0.022826627,
-0.008311729,
-0.00015737637,
-0.019060878,
0.02063424,
0.015810985,
0.037167422,
0.01475348,
0.0028920176,
0.004816805,
-0.0077765286,
-0.009685196,
0.021511193,
-0.010007606,
0.00035727056,
-0.0021279058,
0.004268708,
-0.007428326,
-0.010388049,
0.005780811,
-0.012619127,
0.015501472,
0.010388049,
-0.0021391902,
-0.032473132,
-0.005003803,
0.0048200293,
-0.0050166994,
0.0059968256,
-0.0012831917,
0.0010236517,
-0.0080731455,
-0.008066698,
-0.031725142,
0.0025083497,
0.041500613,
-0.0043847756,
-0.022581596,
0.020801893,
0.0057453457,
-0.0051843524,
-0.003482028,
-0.008292384,
0.01034936,
-0.03871499,
-0.028836349,
0.009162892,
-0.00042437215,
0.0076475646,
0.0010816855,
-0.038250722,
-0.015140372,
0.003907609,
-0.0049586655,
0.024142059,
0.02267187,
0.009685196,
-0.05906551,
-0.02783043,
0.045472704,
-0.015836779,
0.006615853,
-0.010342912,
0.004542757,
-0.017680964,
-0.0027549933,
-0.017500414,
0.019550942,
-0.006615853,
-0.013489634,
0.0015024305,
0.019602528,
-0.009646507,
0.0042816047,
-0.0055099865,
0.0018167803,
0.015179062,
0.00651913,
-0.020763204,
0.002617969,
-0.015927054,
-0.0016072138,
0.0011993651,
0.030203367,
-0.023806753,
0.028630007,
-0.023290897,
0.009227374,
0.0080860425,
0.024632122,
-0.024025992,
-0.016056018,
0.011187626,
-0.0016555752,
-0.02378096,
0.0055776928,
-0.007537945,
-0.02063424,
-0.0005674416,
0.026876096,
0.013799148,
0.016675044,
0.00030024428,
-0.02009259,
-0.000029168028,
0.008105387,
0.0023616531,
-0.0067899544,
-0.01769386,
0.00033691843,
-0.024167852,
0.0013533159,
0.004816805,
-0.018648194,
0.02783043,
0.011252108,
-0.022413941,
-0.02525115,
-0.027856223,
0.0023374723,
-0.0097819185,
0.0046910653,
-0.009465957,
-0.011632552,
0.005790483,
0.0019747613,
0.02424523,
0.008376211,
0.0034659074,
-0.026334448,
-0.0029323187,
-0.00070849597,
-0.025135083,
-0.006847988,
-0.018648194,
0.021678846,
-0.0018651418,
0.044312026,
0.006551371,
0.008279488,
0.044982642,
-0.0037302836,
0.029016899,
-0.002938767,
-0.008653484,
-0.00041087123,
-0.03595516,
-0.022130221,
0.012129064,
-0.011445554,
0.040984757,
0.00737674,
-0.027907807,
-0.0005343945,
-0.003781869,
0.035000827,
-0.030925566,
-0.0038334548,
-0.012960881,
-0.00017460516,
-0.000057580408,
-0.009040376,
0.005287524,
-0.0058323964,
-0.011729275,
0.017719653,
0.0063031153,
-0.007125261,
-0.00067020976,
-0.0025325303,
0.02460633,
-0.0035626304,
0.006906022,
0.029764889,
0.011393969,
-0.0072413282,
0.004413793,
0.020969545,
0.032112036,
0.015101683,
-0.005726001,
-0.00086728286,
0.040417314,
0.0049844584,
0.008414901,
-0.0023003952,
0.02188519,
-0.0010309059,
-0.0022214048,
0.01701035,
0.008376211,
0.022646077,
0.011735723,
0.004845822,
-0.010865216,
0.007911941,
-0.015772296,
0.032576304,
-0.012793228,
0.00034115007,
0.020763204,
-0.011858239,
0.0020166745,
-0.019757284,
0.0005593813,
-0.0143279,
-0.020479482,
-0.003681922,
0.021485401,
0.022091532,
0.026205484,
-0.010910354,
-0.02345855,
-0.017461725,
-0.022039946,
-0.002482557,
0.0039527463,
0.017294072,
0.00070930197,
-0.028320493,
-0.007002745,
-0.035104,
-0.014276314,
0.016172085,
-0.032653682,
0.006225737,
-0.015475679,
0.023342483,
0.01902219,
0.006209616,
0.018828742,
-0.013708873,
-0.03345326,
-0.0065707155,
0.041887503,
-0.0015862571,
-0.021859396,
-0.011529381,
-0.022375252,
-0.010001157,
0.025302736,
0.0019441321,
0.014572931,
0.001454069,
-0.0071510533,
-0.029661719,
-0.024683708,
0.023394069,
-0.0040236767,
0.023845442,
0.0048071328,
0.007937734,
0.011619655,
-0.025986245,
-0.00038346637,
0.038224928,
0.019254325,
0.0054197116,
-0.012457922,
-0.009201581,
-0.021627262,
-0.027108232,
-0.03051288,
0.005045716,
-0.009143547,
-0.0286558,
-0.009543335,
0.005235938,
0.015411197,
0.01848054,
-0.00030911056,
-0.03105453,
-0.018209716,
-0.0028355957,
-0.0028355957,
0.035619855,
0.042635497,
-0.021691743,
0.0046942895,
-0.017848616,
0.02267187,
0.0028904055,
-0.01579809,
0.036109917,
-0.013160775,
0.019293014,
-0.0056808637,
0.016855594,
0.0048909592,
-0.007828115,
0.025625145,
0.0052456106,
0.0016958765,
-0.0037657486,
-0.00059847353,
0.0072090873,
-0.009362786,
0.028604213,
0.037631694,
0.0063482528,
0.008408452,
-0.010239741,
-0.003296642,
-0.000025654263,
-0.002740485,
-0.01851923,
0.021446712,
-0.006899574,
0.019473562,
-0.000011045061,
-0.027675673,
0.011864687,
0.016958766,
-0.01181955,
0.009001687,
-0.0009994709,
0.02335538,
0.009117754,
0.0011743783,
0.004845822,
-0.0009873806,
0.004429913,
0.0017813152,
0.008550312,
-0.0077313916,
0.021872293,
-0.02940379,
-0.03685791,
-0.009111306,
0.01944777,
0.01704904,
-0.012012996,
-0.033582225,
-0.021304851,
0.021395126,
0.0045395326,
-0.029558547,
0.0144826565,
-0.01866109,
0.00393985,
-0.006744817,
0.0011872748,
-0.021330645,
-0.020492379,
0.0003685549,
0.0071768463,
-0.033969115,
-0.034691315,
-0.0074154297,
0.02360041,
0.03198307,
0.0076088756,
-0.00845359,
-0.021111406,
0.03585199,
-0.017655171,
-0.024374194,
0.011529381,
-0.018106544,
-0.018970603,
0.0017942116,
0.0059001027,
0.008711518,
0.006428855,
-0.0062805465,
0.0049683377,
-0.011161834,
-0.007602427,
-0.0179131,
-0.011490691,
-0.004845822,
0.007363844,
0.033788566,
-0.015320922,
0.0004352535,
0.002774338,
-0.025328528,
-0.024258127,
-0.015991535,
-0.0027582175,
-0.010110777,
-0.01902219,
0.0039237295,
-0.015707815,
-0.011187626,
-0.003040326,
-0.015617539,
0.016120499,
0.014701895,
0.028346285,
0.028939521,
0.0065030092,
0.023987303,
-0.0027549933,
-0.00026739878,
0.010362257,
-0.019538045,
0.020131279,
-0.0033530637,
-0.018054958,
0.007531497,
0.0130705,
-0.017126419,
-0.013876526,
0.00549709,
0.0157594,
0.02801098,
-0.003104808,
-0.015269337,
-0.004349311,
0.007782977,
0.0127351945,
0.007105916,
0.01078139,
0.007969975,
0.015153269,
0.013618598,
-0.0011002241,
-0.0031241528,
0.027030854,
-0.03484607,
0.0064095105,
0.021936776,
0.010355809,
-0.0021843277,
0.0046427036,
-0.0096400585,
-0.011697034,
-0.00845359,
-0.015888363,
-0.022478424,
-0.011148937,
-0.018957706,
0.030745016,
0.040804207,
0.025031911,
0.0128641585,
0.015475679,
-0.011671241,
-0.0009648119,
-0.011058662,
-0.01987335,
0.017603585,
-0.019976523,
0.038121756,
-0.020505276,
0.006461096,
0.001548374,
-0.025870178,
0.025483284,
0.034330215,
-0.024799775,
-0.033324298,
-0.0060935486,
-0.027030854,
-0.019924937,
0.0072864657,
-0.0038205583,
0.012554645,
-0.019331703,
0.0028920176,
0.015927054,
0.00737674,
0.008434245,
0.0001648321,
0.024296816,
-0.009233822,
0.019576734,
-0.029094277,
0.027804637,
-0.0035690784,
0.008240799,
-0.00884693,
0.017552,
0.020956649,
0.02500612,
0.0013670183,
0.0054358323,
-0.0015781969,
0.006167703,
0.012425681,
-0.03283423,
-0.025973348,
0.00051545294,
-0.024335505,
-0.0097819185,
0.0015701366,
-0.009523991,
-0.034588143,
-0.006680335,
0.014766377,
-0.031493008,
-0.0015588523,
-0.002231077,
-0.022581596,
0.03492345,
-0.025625145,
0.025044808,
-0.0016039896,
0.008995239,
0.006525578,
-0.0061161174,
-0.013528323,
-0.00813118,
-0.025302736,
0.002493841,
0.039669324,
0.025779903,
-0.022762144,
-0.024206541,
-0.012199994,
-0.00005667363,
-0.025019014,
-0.032034654,
0.0020521395,
-0.003259565,
0.013902319,
0.019641217,
0.000093247014,
-0.03899871,
0.0072090873,
-0.00490708,
0.009362786,
0.004233243,
-0.027469331,
-0.03621309,
0.034330215,
0.0063418043,
0.0035432857,
-0.012580438,
-0.013141431,
-0.0029049139,
-0.009008135,
-0.032086242,
0.013257499,
-0.016713733,
0.027159818,
-0.024322608,
-0.0025454268,
0.0011348831,
-0.012657816,
-0.0040301247,
-0.012922192,
-0.020685824,
0.04395093,
-0.0036174401,
0.030280745,
0.008008664,
0.020208657,
-0.0074863597,
-0.01002695,
-0.008782448,
-0.009910882,
-0.043254524,
0.00762822,
0.022749249,
-0.0013081785,
0.0005968615,
0.012780332,
-0.023394069,
-0.012264476,
-0.016778216,
-0.012593334,
0.01045898,
-0.038663406,
-0.011000629,
-0.000936601,
0.018532125,
-0.00458467,
-0.007595979,
0.021794915,
-0.012206442,
0.024142059,
0.011039318,
0.0048232535,
0.020015212,
-0.014959823,
-0.033659603,
-0.0073896367,
-0.0076991506,
-0.014134454,
0.0036625774,
-0.013579909,
-0.02446447,
0.0057034325,
-0.0005142439,
0.027778843,
0.00008715145,
-0.024387091,
0.006293443,
-0.0074154297,
0.026927682,
0.0067964024,
-0.002421299,
0.0080215605,
-0.024554744,
0.008253695,
-0.006938263,
0.00009490944,
-0.03363381,
-0.008692173,
-0.008182765,
0.008672829,
-0.027624087,
-0.021859396,
0.00096722995,
0.008853378,
-0.017526207,
0.011909825,
-0.030564466,
-0.013089845,
-0.020363415,
0.002943603,
-0.004945769,
-0.011019973,
-0.019525148,
0.048980523,
0.012309613,
0.010097881,
-0.016378427,
0.004671721,
-0.0060903244,
-0.025315631,
-0.02418075,
0.0019215635,
-0.015604643,
0.060613077,
0.0008559985,
0.0044718264,
-0.022375252,
-0.018777158,
-0.044079892,
-0.058085382,
0.022014154,
-0.00006720233,
0.02446447,
0.0052101454,
0.0045395326,
-0.009459509,
0.014869548,
-0.0064901127,
-0.022916902,
-0.009059721,
0.0067061274,
0.002975844,
0.0019280117,
0.00008815898,
-0.011922721,
-0.007750736,
0.020814788,
-0.02267187,
-0.0009551396,
0.019576734,
-0.009021032,
0.015785193,
-0.006325684,
0.014340796,
0.01479217,
0.026102312,
0.03492345,
-0.033401676,
-0.002261706,
-0.0014282762,
-0.0005972645,
-0.021794915,
0.02055686,
-0.015914157,
-0.0097045405,
0.008395556,
-0.027907807,
-0.023613308,
-0.0036658016,
-0.025096392,
0.03693529,
0.01557885,
0.0068931254,
0.015991535,
-0.004874839,
-0.019383289,
-0.014173143,
0.007434774,
-0.022362357,
-0.0074541187,
0.01479217,
-0.003581975,
0.0011864688,
0.012232235,
-0.0013033424,
-0.001453263,
-0.003965643,
0.014018386,
-0.012896399,
-0.05401012,
0.016842697,
0.0008382659,
-0.0014105437,
-0.005487418,
0.008821137,
-0.021085612,
-0.0020456912,
0.0019538044,
-0.009891538,
0.007099468,
0.0019812093,
0.006751265,
0.001968313,
-0.0051779044,
0.0008439081,
0.0030242056,
-0.00028916146,
0.026592376,
0.1801369,
-0.025973348,
0.0081376275,
0.015153269,
-0.014263418,
-0.010839423,
0.0025760557,
0.012954433,
0.00067383685,
-0.009201581,
0.054216463,
-0.008066698,
0.005822724,
-0.006064532,
0.042171225,
-0.0401078,
-0.02124037,
0.0030612827,
-0.0035884231,
-0.015565954,
-0.01557885,
-0.017603585,
0.013541219,
0.013876526,
0.017036144,
0.016675044,
-0.02055686,
0.020853478,
0.021175887,
-0.009865746,
-0.02690189,
-0.00042195406,
-0.009872193,
-0.0038237823,
0.00021762674,
-0.008350419,
0.00083181774,
-0.014572931,
0.013096293,
-0.0040688138,
-0.003907609,
0.0127996765,
-0.018699778,
0.015398301,
-0.007750736,
0.034794487,
0.003581975,
-0.0017603585,
0.011896929,
-0.00034397116,
-0.043641414,
-0.006815747,
0.011123144,
0.011729275,
0.0037915413,
-0.010839423,
0.011303694,
0.0050973017,
-0.013064053,
0.018132338,
-0.008414901,
0.016571874,
-0.025302736,
-0.004965114,
-0.008369763,
0.016558977,
0.011078007,
0.010271982,
0.003717387,
-0.011729275,
-0.013889422,
-0.0043106214,
0.00003370192,
-0.006561043,
0.010246189,
-0.029764889,
0.039411396,
0.031493008,
0.010691115,
-0.009582025,
-0.00033349282,
-0.0044718264,
-0.021188784,
-0.011651897,
0.0022149566,
-0.021498298,
0.03484607,
0.015062994,
-0.012844814,
-0.017113522,
0.0014943703,
-0.010723356,
-0.00497801,
0.00834397,
0.008576105,
-0.01572071,
0.009588473,
0.017487517,
-0.018673986,
-0.021356437,
-0.028939521,
0.05906551,
0.04018518,
0.0043202937,
-0.0069253664,
0.0021811035,
-0.0010526686,
0.024503158,
-0.015062994,
-0.019396184,
0.0066416455,
-0.02718561,
0.023032969,
-0.00035041934,
0.006099997,
0.026772926,
0.01565623,
-0.057827454,
0.039334018,
-0.0029016898,
-0.01034936,
-0.025096392,
0.01608181,
0.021872293,
-0.013186568,
0.0047813402,
0.008834033,
0.028217321,
-0.008589002,
-0.003878592,
-0.024399988,
0.011000629,
0.011980755,
0.006615853,
0.0024084025,
0.011490691,
-0.00089307566,
-0.0073509477,
-0.009059721,
-0.00619672,
-0.007789425,
-0.007789425,
0.0027678898,
0.013979697,
-0.010607288,
-0.016997455,
0.01414735,
0.020853478,
-0.027340367,
-0.01507589,
-0.02754671,
-0.020814788,
-0.008627691,
-0.005422936,
0.009723885,
-0.013438048,
0.003968867,
-0.03180252,
0.0053004203,
0.0080860425,
-0.028965313,
0.024051785,
0.008627691,
-0.0144955525,
-0.0051940246,
0.004171985,
-0.15847096,
-0.020750307,
0.028604213,
-0.013541219,
0.028604213,
0.0112456605,
0.006306339,
-0.0145858275,
-0.004452482,
-0.011252108,
0.033324298,
0.004916752,
-0.020801893,
-0.028578421,
0.035516683,
0.0018216164,
0.0052262656,
0.042429153,
-0.0010534746,
0.0008971058,
0.012909296,
-0.01654608,
0.021201681,
-0.0018377369,
-0.0058839824,
0.020479482,
0.014431071,
0.0016620235,
-0.0000034791312,
-0.022156013,
-0.019473562,
-0.009523991,
0.006783506,
0.007460567,
0.006193496,
0.0046104626,
-0.0036690256,
-0.0025615473,
0.014340796,
0.005142439,
0.027572501,
0.014908237,
0.014211832,
-0.011580966,
0.002614745,
0.042532325,
-0.0066416455,
0.0028001308,
0.025960451,
-0.001518551,
0.027985187,
-0.0126965055,
0.0019425201,
0.0001500214,
0.015927054,
-0.015965743,
0.021227473,
-0.0005259313,
0.012103271,
0.008234351,
0.007963527,
0.00091000216,
0.038276512,
-0.013057604,
-0.011142489,
-0.031235078,
0.013257499,
0.024025992,
-0.015823882,
0.011600311,
-0.004971562,
0.026153898,
0.023755167,
-0.011026422,
0.030745016,
0.025741212,
-0.0070156413,
0.00730581,
0.0011139265,
-0.0009116142,
-0.040675245,
0.042068053,
-0.027314574,
-0.035258755,
-0.001292864,
0.01461162,
-0.00074234896,
0.01855792,
-0.009685196,
-0.0112843495,
0.007499256,
-0.024193645,
-0.0024809449,
0.0005485,
0.03270527,
0.012793228,
-0.027211402,
-0.027030854,
-0.00619672,
0.0033369432,
0.010336464,
-0.0064417515,
-0.014044179,
0.007363844,
0.056640986,
0.0054745213,
0.019293014,
0.0029951888,
0.043821964,
-0.011161834,
0.0080344565,
-0.003549734,
-0.002485781,
0.013953904,
-0.006435303,
0.041500613,
0.00445893,
0.019963626,
-0.00625153,
-0.0061548064,
0.09275091,
-0.009182236,
0.0010913578,
0.036058333,
-0.012135512,
-0.005816276,
-0.12947986,
-0.0018877104,
-0.015849674,
0.02263318,
0.007344499,
0.008537416,
-0.008769551,
0.02360041,
0.0079570785,
0.024554744,
-0.014366589,
-0.01608181,
0.025367217,
-0.0040881587,
0.0009801263,
0.018287094,
0.006654542,
-0.0038334548,
-0.024632122,
0.026592376,
-0.010046295,
-0.007041434,
-0.02341986,
-0.010426739,
0.0079570785,
0.015540161,
-0.033479054,
0.014817962,
0.015217751,
0.018790053,
0.0097432295,
-0.005780811,
0.003720611,
0.002490617,
-0.023806753,
0.008705069,
-0.010510566,
-0.010059192,
0.03399491,
-0.015295129,
-0.011903376,
0.014224729,
0.0025019015,
-0.021575676,
0.021627262,
-0.015449886,
-0.024490261,
-0.0005521271,
0.0044750506,
-0.01815813,
-0.045214776,
-0.017706756,
-0.031235078,
-0.012129064,
0.011342383,
-0.01690718,
0.0009897987,
0.012071029,
-0.027082438,
0.010388049,
-0.014237625,
-0.022904005,
0.009336993,
-0.007828115,
0.0059001027,
-0.01479217,
-0.02174333,
-0.03409808,
0.015475679,
-0.016004432,
-0.0036367846,
-0.012619127,
-0.021549882,
-0.011510036,
-0.009530439,
0.009988261,
-0.029429583,
0.0029581117,
0.0058356207,
-0.0096658515,
-0.0057775867,
-0.026205484,
0.030125989,
-0.0064256308,
0.023948614,
0.0146245165,
0.01622367,
-0.0053874706,
0.0066996794,
-0.000015679705,
-0.027211402,
0.03430442,
-0.016675044,
-0.036445223,
-0.009859297,
0.014895341,
0.025509078,
0.003652905,
0.029145863,
0.030641844,
-0.022697663,
-0.035155583,
-0.044647336,
0.02603783,
0.008189213,
-0.0026824512,
0.016172085,
-0.010787838,
0.021910982,
-0.010678219,
0.0026711668,
0.013708873,
0.0031112563,
0.010955491,
-0.033427466,
-0.012831917,
-0.025663834,
-0.009046824,
0.0047555473,
0.01235475,
-0.0017668067,
0.016210774,
-0.022826627,
0.0171909,
0.029016899,
0.021601468,
0.01636553,
-0.008440693,
-0.013476737,
0.027675673,
0.005967809,
-0.008066698,
0.0073187067,
-0.05076023,
-0.028887935,
-0.01525644,
-0.017319864,
-0.020956649,
0.0095368875,
0.025805695,
0.024090474,
0.040597863,
-0.0039462983,
-0.014946926,
-0.006593284,
-0.006493337,
-0.008827586,
0.011806654,
-0.001034936,
0.01708773,
-0.012245131,
-0.026979268,
0.039849874,
-0.0056163818,
-0.0005392307,
-0.04175854,
-0.03180252,
0.009117754,
0.020157073,
-0.014289211,
0.020144176,
-0.03033233,
0.007370292,
0.009672299,
0.0012751315,
-0.011090904,
-0.010807183,
-0.021820707,
-0.008040905,
-0.00406559,
-0.02525115,
-0.033298504,
-0.022388149,
0.013605701,
0.02672134,
0.009949572,
-0.005045716,
0.006996297,
-0.022581596,
0.010575048,
-0.0078023216,
0.011090904,
0.0030774032,
-0.0098077115,
-0.0120001,
0.0032176515,
0.044647336,
-0.0111038,
0.0040494693,
0.06288284,
0.005580917,
0.016842697,
-0.012722298,
0.0032144275,
0.005626054,
-0.002287499,
0.008647036,
0.028939521,
-0.014701895,
0.031544592,
-0.00058920425,
0.03843127,
0.015488575,
-0.02253001,
0.011658345,
-0.02170464,
-0.025676731,
0.021046923,
-0.026115209,
-0.038766578,
-0.0017571345,
0.011639,
0.021008234,
0.008589002,
-0.0012582049,
-0.003681922,
-0.00607098,
0.0070220893,
-0.003037102,
-0.011303694,
-0.019886248,
0.048593633,
0.0018377369,
0.022736352,
0.008608347,
-0.0006299085,
0.009749678,
0.004371879,
0.017126419,
-0.011587415,
0.018673986,
-0.011690586,
0.035361927,
0.020582654,
-0.03376277,
-0.0020102262,
-0.011510036,
-0.030667638,
0.023729375,
0.043435074,
0.0026566582,
0.07918389,
-0.005645399,
-0.0145471385,
0.003843127,
-0.008150524,
0.006873781,
0.028991105,
-0.0041881055,
-0.02464502,
-0.014263418,
0.011393969,
-0.023303794,
0.02198836,
-0.026747132,
-0.022143118,
0.033143748,
0.002843656,
0.0024325834,
-0.009659403,
-0.0038012136,
0.014908237,
-0.021949671,
0.011858239,
0.04129427,
-0.008782448,
0.010839423,
0.04219702,
-0.012625575,
0.016842697,
0.008234351,
0.0129415365,
-0.01844185,
-0.03549089,
-0.015424093,
-0.005200473,
-0.012935089,
0.012161304,
-0.02170464,
0.01902219,
0.012309613,
-0.023032969,
-0.0018699779,
-0.017229589,
-0.010807183,
-0.00043847758,
-0.009975364,
-0.0069898483,
-0.017448828,
-0.007338051
] |
Information on global human movement patterns is central to spatial epidemiological models used to predict the behavior of influenza and other infectious diseases. Yet it remains difficult to test which modes of dispersal drive pathogen spread at various geographic scales using standard epidemiological data alone. Evolutionary analyses of pathogen genome sequences increasingly provide insights into the spatial dynamics of influenza viruses, but to date they have largely neglected the wealth of information on human mobility, mainly because no statistical framework exists within which viral gene sequences and empirical data on host movement can be combined. Here, we address this problem by applying a phylogeographic approach to elucidate the global spread of human | [
-0.013133379,
0.005667053,
0.013245013,
-0.016140923,
-0.001297742,
0.025675757,
-0.015339787,
0.0054470687,
-0.017204726,
-0.025977824,
-0.014499251,
0.0024165418,
0.0023131163,
0.02285208,
0.0040253806,
0.01422345,
0.038454533,
-0.013698114,
0.015011452,
-0.0109729385,
-0.01866253,
0.01251611,
0.021210408,
-0.035039857,
-0.016048988,
0.04108121,
0.013645581,
-0.038296934,
-0.008359396,
-0.014446717,
0.016311657,
0.0009538116,
-0.006658623,
-0.013376347,
-0.027002227,
-0.018452397,
0.0012796837,
-0.030968508,
0.0095611,
-0.026923427,
0.0051942514,
0.0125358105,
-0.020934606,
-0.009705567,
0.011997342,
0.007893161,
0.0011705124,
-0.021656942,
-0.020277938,
0.010303136,
0.003923597,
0.013461714,
-0.030889707,
0.0007100233,
-0.0096596,
-0.013087412,
-0.0025544423,
-0.027396228,
0.013514247,
-0.036248125,
-0.00092672405,
0.006599523,
-0.03595919,
0.013277846,
-0.010519837,
-0.0033916952,
-0.00757796,
0.0012394626,
0.012719678,
0.017821996,
0.029156102,
0.022760145,
-0.0015760055,
0.014512383,
0.026805226,
0.000957095,
0.012115542,
-0.004189548,
-0.023548149,
0.01422345,
0.009902568,
-0.02300968,
0.0189646,
0.024178552,
0.017887663,
0.009896001,
0.022103477,
0.020343604,
-0.006888457,
0.0076042265,
-0.011774074,
-0.00017576155,
0.0058049536,
0.016022723,
-0.015510521,
-0.0013798256,
-0.027737696,
0.015760055,
0.015865121,
-0.015063986,
-0.029129835,
0.01059207,
-0.03669466,
-0.003772563,
-0.029523836,
-0.014210316,
0.019962735,
-0.0043865484,
0.02118414,
-0.01535292,
-0.025728289,
0.00079456944,
-0.014433583,
-0.027685164,
0.011294706,
-0.014932652,
0.014275983,
-0.016534925,
-0.0038940469,
-0.025255488,
0.019516202,
0.017244127,
0.0004654141,
0.0032997616,
0.026148558,
0.007912861,
-0.042000547,
0.0032308113,
-0.0023804249,
-0.026516292,
-0.020028403,
-0.004885617,
-0.0029221768,
0.0030518689,
-0.03070584,
0.0076501933,
-0.0115770735,
-0.0038053966,
-0.019463668,
-0.028578233,
0.006589673,
0.014591184,
-0.008444763,
0.0069015906,
0.009502,
0.033989184,
0.031047309,
0.0063861054,
0.02997037,
0.013579914,
0.030968508,
-0.016351057,
0.03677346,
-0.0005819729,
-0.004439082,
0.021591276,
-0.018872665,
0.017953329,
-0.009836901,
-0.029576369,
-0.016863259,
-0.0050629177,
0.0066257897,
0.021394275,
-0.0017401727,
0.016745059,
0.00046130994,
-0.0016843559,
-0.0072890255,
-0.010040469,
-0.03556519,
0.022707613,
-0.025452489,
0.0022540162,
0.013947649,
0.016351057,
0.0034409454,
0.011892275,
-0.016653124,
-0.014551784,
-0.007886594,
0.015221586,
0.033673983,
0.0039859805,
-0.007919428,
-0.019608134,
0.036405727,
-0.014078982,
0.002460867,
-0.025281755,
-0.0073743924,
-0.015208453,
0.018557465,
0.006323722,
-0.6446913,
-0.017388593,
0.01815033,
-0.03897987,
-0.008326562,
-0.015195319,
0.020974007,
-0.007105158,
-0.0015719013,
0.023653215,
-0.013803181,
0.02499282,
0.0007412151,
-0.03222931,
-0.043734152,
-0.027763963,
0.0024641503,
-0.030075438,
0.024112884,
0.016232856,
-0.022878347,
0.028026631,
0.012745945,
0.04239455,
-0.0058903205,
0.009153965,
0.0101521015,
-0.014092116,
0.02390275,
0.027658897,
-0.021433674,
0.030732106,
-0.0039761304,
-0.005381402,
0.04496869,
-0.018990867,
-0.013061145,
0.023232948,
0.02580709,
0.04147521,
-0.02612229,
-0.025294889,
0.0024986253,
0.030233039,
0.0062449216,
0.012194342,
-0.011682141,
-0.010815337,
0.012581777,
-0.013258146,
-0.013080846,
0.01973947,
-0.014275983,
0.011202772,
0.012128675,
-0.0019535902,
-0.0055357195,
-0.017309794,
0.023679482,
0.0014988469,
0.0034606454,
0.0133566465,
-0.015142786,
-0.007111725,
-0.028972235,
0.025977824,
-0.0052270847,
0.0035755625,
0.011386639,
-0.024441218,
0.031309977,
0.02981277,
-0.0028253181,
0.0016400306,
0.013461714,
0.021814542,
0.0042617815,
0.000023894028,
-0.021197274,
-0.0068162237,
-0.0013658714,
0.0082871625,
-0.03141504,
-0.0037462963,
0.011215906,
-0.018977733,
-0.033411317,
0.016495524,
-0.0031864862,
0.00074285676,
0.02114474,
0.015287253,
-0.013829448,
-0.017703796,
-0.0046787662,
0.018583732,
-0.0053584184,
0.000821657,
0.0027711429,
-0.0051647015,
-0.01422345,
-0.015523654,
0.022536878,
0.0033014033,
0.019765735,
0.0136587145,
-0.008280596,
0.01985767,
0.028735833,
-0.012969212,
0.005046501,
-0.0082346285,
0.0033490115,
-0.005030084,
0.008681163,
-0.02561009,
0.029208634,
-0.00016067868,
0.00470175,
-0.029944103,
0.00047115996,
0.0031635028,
0.014564917,
-0.022182276,
0.015339787,
0.026792092,
-0.010112702,
-0.010106135,
-0.019581867,
-0.025583822,
-0.0101521015,
-0.02223481,
0.009928835,
-0.012168076,
0.029891571,
0.00583122,
0.024533153,
-0.004478482,
-0.021617541,
-0.031309977,
-0.03257078,
-0.023521882,
-0.0051220176,
-0.011261873,
-0.005296035,
-0.012509543,
0.011596774,
-0.013816315,
-0.0014052716,
-0.010539536,
0.0008179633,
-0.009804067,
-0.0042913314,
0.011944808,
0.008484162,
0.01235851,
0.004951284,
-0.033227447,
-0.012220609,
-0.0042223814,
0.023705749,
0.004465349,
-0.0032373779,
0.015563054,
-0.00035008663,
-0.012654011,
-0.00022593516,
0.0013272921,
0.018426131,
-0.038953602,
0.0035197455,
-0.004334015,
-0.001613764,
0.02981277,
-0.0035591456,
0.0012000625,
-0.007860327,
0.007124858,
-0.024506886,
-0.021039674,
0.0071379915,
-0.009876301,
-0.02021227,
0.011517974,
0.016587459,
0.015142786,
0.026726427,
0.0021522325,
0.010106135,
0.023246082,
0.02786903,
0.026109157,
-0.000114917064,
-0.009206499,
0.025386821,
0.0008261716,
0.00576227,
0.013074279,
-0.0131662125,
0.011734674,
0.03461959,
-0.014170916,
-0.012719678,
-0.018334197,
0.013153079,
-0.037482664,
-0.006343422,
-0.016692525,
0.0191616,
0.012680277,
0.0106446035,
-0.015208453,
-0.018255398,
0.0029730687,
-0.010086435,
0.008004795,
-0.018793866,
0.01245701,
-0.018005863,
0.009318132,
-0.030863442,
0.0012131959,
0.026253624,
0.008562963,
-0.008352829,
0.009672734,
-0.01344858,
0.02771143,
0.014709384,
-0.0032439446,
-0.0070197913,
0.026201092,
0.015405454,
0.022339879,
0.024533153,
0.0062613385,
-0.01342888,
-0.0015226512,
0.016692525,
0.0052139517,
0.005854204,
-0.0042781984,
0.030968508,
-0.015050853,
0.010047035,
0.00672429,
0.021853942,
0.0012632669,
-0.018018996,
0.0286833,
-0.010342536,
-0.013790048,
-0.004265065,
-0.01156394,
0.011596774,
-0.024966553,
-0.012627744,
-0.024861487,
0.04917137,
0.031152375,
0.0056933197,
-0.010408203,
0.0023820666,
-0.013363213,
0.0032193195,
-0.016955193,
-0.013487981,
-0.021814542,
-0.0074466257,
0.034908522,
-0.02386335,
-0.008392229,
0.031651445,
0.0021538741,
0.011380073,
0.01531352,
0.016626857,
-0.016062122,
0.0072561917,
-0.0019535902,
-0.0054339357,
-0.038139332,
-0.00288606,
0.024782686,
-0.007111725,
-0.031809043,
-0.012883845,
0.010789071,
-0.015825722,
-0.0082346285,
0.0054339357,
0.0034310953,
-0.01985767,
-0.007880027,
-0.0033014033,
0.012686844,
0.027737696,
-0.000023675993,
0.0008692655,
0.012956078,
-0.009554533,
0.0035689957,
-0.02580709,
-0.020974007,
0.02677896,
0.02771143,
0.011623041,
-0.007315292,
-0.01660059,
0.0022737163,
0.0009209782,
-0.026568826,
-0.017979596,
-0.0040155305,
-0.011130539,
0.02600409,
-0.017927062,
0.0074531925,
0.04609816,
-0.013501113,
-0.023180414,
-0.031782776,
-0.03961027,
-0.0056309365,
0.06156928,
0.0071576918,
-0.008122995,
0.020107204,
0.012010475,
-0.004012247,
0.012082709,
0.00039625866,
0.025833357,
-0.009035765,
-0.023850216,
0.0103162695,
0.009337832,
0.009475733,
0.02048807,
0.017835129,
0.010835038,
-0.020566871,
-0.021171007,
0.0077683935,
0.0011959583,
-0.025557555,
0.004389832,
0.032439448,
0.037298795,
-0.003752863,
0.0029993355,
0.011412906,
-0.01251611,
-0.017651262,
-0.005351852,
0.028867166,
0.0019568736,
0.03128371,
-0.006113588,
0.00044981824,
0.0005942854,
-0.012745945,
0.009863168,
0.00042273063,
0.023364281,
0.00036404084,
0.0036215293,
-0.0034869122,
-0.010821904,
0.007354692,
-0.014000182,
0.015694387,
0.00025774256,
-0.02235301,
0.03451452,
-0.020514337,
-0.022011543,
-0.040319473,
0.020711338,
0.0043865484,
0.003523029,
-0.006730857,
-0.03054824,
-0.01600959,
-0.037955467,
-0.020763872,
0.009436333,
0.009896001,
-0.006051204,
-0.004330732,
-0.018005863,
0.015628722,
-0.028236765,
-0.012489843,
0.024533153,
-0.050195776,
-0.0068293572,
-0.016587459,
0.020908339,
0.019148467,
0.010303136,
-0.022983413,
-0.007742127,
0.005522586,
-0.011386639,
-0.013185913,
-0.014788184,
-0.018977733,
0.008713997,
0.009206499,
0.00014200466,
-0.0098237675,
-0.0040647807,
0.00022942372,
0.011491707,
0.015287253,
0.0060873213,
0.0016753266,
-0.015326654,
0.046045627,
0.0028696433,
0.033568915,
-0.0024346001,
-0.0069803908,
0.016456123,
-0.034645855,
-0.006504306,
-0.0019010566,
-0.0035722791,
-0.024270484,
-0.009272166,
0.0028450182,
-0.0027383096,
-0.031231176,
0.019962735,
-0.029839037,
0.017940195,
0.00022942372,
0.043208815,
0.0072561917,
0.025754556,
-0.014013316,
0.021578142,
-0.022865213,
-0.008365963,
0.022129744,
0.009574234,
0.005039934,
-0.0064517725,
0.010841604,
-0.003713463,
-0.0018912066,
-0.025045354,
-0.01838673,
-0.0003923597,
0.041948013,
0.016653124,
-0.02328548,
-0.010881005,
-0.0045769825,
-0.018097796,
0.0111371055,
-0.005102318,
-0.015641855,
0.0013855714,
-0.019818269,
0.018110929,
-0.017638128,
0.025321154,
-0.03435692,
0.009304999,
0.019831402,
-0.017900795,
0.007991661,
-0.007170825,
-0.012450444,
0.0038579302,
-0.018360464,
-0.023311747,
-0.012857578,
-0.02269448,
-0.0036051124,
0.02219541,
0.008208361,
0.039111204,
-0.007591093,
0.00672429,
0.023889616,
-0.0052993186,
-0.010047035,
-0.02130234,
-0.0042322315,
-0.018334197,
0.022865213,
0.022142878,
0.010920404,
-0.021617541,
0.0011606624,
0.015011452,
-0.00020079705,
-0.0049742674,
-0.032071713,
-0.0013363214,
-0.035118654,
-0.016928926,
-0.0041370145,
-0.0064977393,
0.009016065,
-0.04326135,
0.0045933994,
0.03264958,
-0.008622063,
0.00765676,
0.000023624692,
0.007229925,
-0.0010326119,
0.0286045,
-0.0105067035,
-0.0010711913,
-0.036957327,
-0.009436333,
-0.02949757,
-0.0052993186,
0.021683209,
-0.027448762,
0.019095933,
0.0012706544,
0.016022723,
0.014065849,
0.012168076,
-0.013172779,
0.012286276,
0.0076895934,
-0.019069666,
-0.0005265664,
-0.019870803,
-0.004284765,
-0.03183531,
-0.012240309,
-0.0127262445,
0.007361259,
0.0095216995,
-0.03606426,
-0.017861396,
0.01838673,
0.011925108,
-0.0016022723,
0.0033605034,
0.05248098,
0.01247671,
-0.01624599,
-0.029234901,
0.0069409907,
-0.012246876,
-0.005988821,
0.019818269,
-0.023219815,
-0.026975961,
-0.025347421,
0.020763872,
0.007781527,
0.0035919792,
-0.03159891,
0.03459332,
0.024756419,
0.005030084,
-0.015799455,
-0.015615588,
-0.012023608,
0.027816497,
-0.008103295,
0.02195901,
-0.0041173142,
-0.022983413,
0.009666167,
0.01352738,
0.017283527,
0.01434165,
-0.008149262,
-0.016088389,
-0.0074597592,
-0.022129744,
0.007919428,
0.0013987048,
0.006057771,
0.0058246534,
0.007361259,
-0.001809123,
0.0194374,
0.027763963,
-0.009107999,
0.01422345,
-0.00676369,
0.038717203,
-0.044101886,
-0.02239241,
-0.0013084129,
-0.005877187,
0.006169405,
0.015497387,
-0.0024723585,
-0.027921563,
-0.00039420658,
0.0028680016,
0.031126108,
0.01134724,
0.010217769,
-0.018452397,
-0.014499251,
-0.007111725,
-0.020225404,
-0.024611952,
0.010322836,
-0.025281755,
0.0024592252,
0.0047280164,
0.011209339,
0.024467485,
0.015024586,
0.0005770478,
-0.01430225,
0.025163554,
-0.02452002,
0.020895205,
0.029234901,
0.0049250172,
-0.039899204,
-0.0012952795,
-0.016850125,
-0.024112884,
0.008523563,
0.010546103,
-0.008484162,
-0.00018756108,
-0.007866894,
0.02779023,
0.007978528,
-0.012739378,
0.00664549,
-0.008464463,
0.011202772,
-0.011248739,
-0.020566871,
0.043629084,
-0.015563054,
0.0069869575,
0.013146512,
0.003959714,
0.034645855,
-0.013126812,
0.019056533,
0.010329403,
-0.004153431,
-0.026227359,
-0.031126108,
0.012141809,
-0.0015998097,
0.0036642128,
-0.0013355005,
-0.006097171,
-0.007886594,
0.0043504317,
-0.0057885367,
0.008503863,
0.00018335428,
-0.013724381,
-0.0094823,
0.020396138,
0.0037758464,
0.0003626044,
0.0039465805,
-0.011334106,
-0.027028494,
-0.0033342366,
-0.0055587026,
0.020028403,
0.020868938,
-0.022274211,
-0.025899023,
-0.0011623041,
-0.06109648,
-0.027606362,
0.01335008,
0.011038605,
-0.0131924795,
0.031467576,
-0.016351057,
0.00577212,
-0.01445985,
0.015011452,
0.014840718,
0.0043175984,
0.017112793,
-0.013120245,
-0.004550716,
0.038296934,
-0.018885799,
-0.006835924,
0.013317246,
0.0058903205,
-0.027186094,
0.015037719,
-0.014118383,
0.005483186,
-0.018872665,
0.022484345,
0.00028893433,
0.0019601567,
0.006218655,
-0.014998319,
-0.03588039,
0.011557373,
-0.01132754,
-0.018439265,
-0.019634401,
-0.007531993,
0.004393115,
0.019923337,
0.0052894684,
-0.035775326,
0.025912156,
-0.0070526246,
0.007164258,
0.0053223018,
0.017585594,
0.017927062,
0.0052894684,
0.005601386,
0.008773097,
-0.021486208,
-0.007440059,
0.013310679,
0.012312543,
0.007820928,
-0.008063895,
-0.0065831062,
0.012745945,
-0.0059461375,
-0.0020767155,
-0.022563145,
-0.014551784,
-0.014236582,
0.01834733,
0.027527563,
-0.0082871625,
-0.0032734948,
-0.014564917,
-0.022247944,
-0.019581867,
0.0031503693,
0.0011746166,
-0.004379982,
0.021630675,
0.0096399,
0.004425949,
-0.0006895024,
0.015418587,
-0.0095216995,
-0.022996547,
0.007847194,
0.17808862,
-0.015720654,
-0.0050596343,
0.000987466,
0.0061497046,
0.01620659,
0.025793957,
0.0035164622,
0.0014323591,
-0.00074942346,
0.013251579,
-0.005611236,
-0.0047674165,
0.008582663,
-0.014840718,
0.009725267,
-0.04586176,
-0.014958919,
-0.006494456,
0.0040910477,
0.003137236,
-0.007847194,
-0.0191222,
-0.01148514,
0.029681437,
0.000326898,
-0.037561465,
0.018728198,
0.00386778,
-0.0036412294,
-0.008871597,
-0.008963531,
-0.0051548514,
0.028657032,
-0.014591184,
-0.0021883494,
0.019030266,
-0.010966372,
0.022418678,
-0.0018616564,
0.0035788459,
-0.0009078448,
0.003156936,
-0.019581867,
0.014039583,
0.011373506,
-0.0053748353,
-0.0009710492,
-0.013737515,
-0.010093002,
-0.038113065,
-0.033122383,
-0.021840809,
0.0016712225,
-0.03191411,
0.012187776,
0.018097796,
0.0075254263,
-0.015366053,
0.025688889,
-0.010230903,
-0.006415656,
-0.012483276,
0.011846308,
-0.020474939,
0.040949877,
0.008274029,
-0.016784457,
0.0072036586,
-0.023075348,
0.014367917,
-0.026529426,
-0.007170825,
0.01239791,
-0.005988821,
-0.004826517,
0.015418587,
0.018649397,
0.02965517,
0.014446717,
-0.021709476,
0.014118383,
-0.04116001,
-0.012509543,
0.0058968873,
-0.04139641,
0.0384808,
0.0068293572,
-0.0479631,
0.020619405,
-0.0044522155,
0.0027793513,
-0.00074901304,
-0.0034540787,
0.004304465,
0.0024313168,
0.0011680499,
-0.007426926,
-0.0008023674,
-0.005962554,
-0.011800341,
0.055948194,
0.032518245,
-0.0038874801,
0.02332488,
0.018439265,
-0.0059001707,
-0.0055751195,
0.014788184,
-0.026214225,
-0.0055882526,
-0.024034083,
0.008694297,
0.005292752,
0.016797591,
0.005292752,
0.045572825,
-0.010060168,
0.027606362,
0.019135334,
0.009396933,
-0.014512383,
0.017362326,
0.042342015,
0.014827585,
-0.01597019,
-0.012161509,
-0.0010843246,
-0.005601386,
-0.010762804,
-0.003582129,
-0.010283436,
-0.014184049,
-0.0028450182,
-0.003943297,
-0.004242081,
0.0050990344,
-0.03257078,
-0.0046787662,
-0.007781527,
-0.0194374,
-0.013566781,
0.03564399,
0.02017287,
0.00058771874,
-0.007860327,
-0.005552136,
0.014551784,
-0.0032340945,
-0.02705476,
-0.009147398,
-0.025872756,
-0.009915701,
0.011793775,
0.0114391735,
-0.026398093,
-0.016075255,
-0.013632447,
0.018570598,
-0.010802204,
-0.0094626,
0.03401545,
0.024336152,
-0.009790934,
-0.010664304,
0.008838764,
-0.16464004,
0.01154424,
0.005450352,
-0.0149195185,
0.021972142,
0.010027335,
0.023758283,
-0.017651262,
0.0053584184,
0.012240309,
0.037614,
0.0047214497,
-0.038507067,
0.007400659,
0.014486117,
-0.014157782,
-0.024625085,
0.033411317,
0.026384959,
0.007952261,
0.037587732,
-0.03314865,
0.014827585,
-0.026069757,
-0.012430743,
-0.0013502755,
-0.009567667,
0.022707613,
-0.011071439,
-0.032807183,
-0.016810725,
0.014236582,
0.04270975,
0.002350875,
0.0070591914,
-0.0016925642,
0.010598637,
-0.016653124,
-0.022274211,
-0.006399239,
0.048908703,
0.028551966,
0.009016065,
-0.0011590207,
0.0021916325,
-0.012562077,
-0.010881005,
0.0004990684,
0.014722518,
-0.014683118,
0.0077289934,
0.004471916,
-0.0046656327,
0.008983231,
0.008221495,
0.003281703,
0.022523746,
0.011800341,
0.014564917,
-0.022681346,
-0.027527563,
-0.013881981,
0.010900704,
-0.0050694845,
-0.0053584184,
-0.032097977,
-0.01706026,
0.022983413,
-0.025780823,
0.010375369,
-0.010684004,
0.019700069,
0.008576096,
-0.014788184,
0.026332425,
0.014000182,
-0.012128675,
0.018321063,
-0.0020783572,
-0.022550011,
-0.021945877,
0.026437491,
-0.021499341,
-0.0022293911,
0.01531352,
-0.008516996,
-0.0028171097,
0.0088912975,
0.013540514,
-0.001728681,
0.013829448,
-0.015641855,
0.020606272,
-0.015720654,
0.04481109,
0.015484254,
0.022641946,
-0.012181209,
0.014722518,
0.015786322,
-0.00672429,
-0.009324699,
-0.019503068,
0.03427812,
0.03070584,
-0.006888457,
-0.011393206,
0.0034606454,
0.034383185,
-0.007906294,
-0.024309885,
-0.01535292,
0.010171802,
0.015825722,
-0.016797591,
0.029996637,
-0.012548944,
-0.0008429988,
0.016587459,
-0.008359396,
0.05169298,
-0.010224336,
-0.02033047,
0.014827585,
-0.013973915,
-0.013461714,
-0.13963409,
-0.0052632014,
-0.0004223202,
-0.007361259,
-0.011977642,
0.018912066,
-0.005181118,
0.029944103,
-0.015129653,
0.022182276,
-0.027133562,
-0.027238628,
-0.0065568397,
-0.018018996,
0.035381325,
-0.00289591,
-0.0037758464,
-0.008924131,
0.0023032664,
0.029103568,
0.0038119634,
-0.03327998,
-0.008044194,
-0.016390458,
0.0061267214,
0.025413089,
-0.021171007,
0.018570598,
-0.0053846855,
-0.006770257,
-0.00286636,
-0.011130539,
0.014801318,
-0.02114474,
-0.00026943948,
0.00002790843,
-0.013107113,
-0.018557465,
0.009213066,
-0.011380073,
0.015142786,
0.03175651,
0.002966502,
0.0022458078,
-0.004970984,
-0.026227359,
-0.011971075,
0.012128675,
-0.0133303795,
-0.026069757,
-0.015681254,
-0.016298523,
-0.018294796,
-0.020501204,
0.014078982,
-0.012588344,
-0.006139855,
-0.005686753,
-0.002290133,
-0.00046664538,
-0.02094774,
-0.0070591914,
-0.02467762,
0.007610793,
0.0029139684,
-0.02810543,
-0.029051034,
-0.002460867,
0.02600409,
-0.02332488,
-0.017861396,
0.018281663,
-0.008070461,
-0.0033046864,
-0.032097977,
0.0060347877,
-0.010835038,
0.0077683935,
0.009062031,
-0.0071314247,
-0.0051548514,
-0.024047216,
0.027606362,
-0.028525699,
0.041711614,
0.014683118,
-0.00018745847,
0.010079868,
0.010585504,
0.0062153717,
-0.0038546468,
0.0288409,
0.00038743467,
-0.01826853,
-0.006464906,
0.017309794,
-0.022563145,
-0.013205613,
0.006172688,
0.02289148,
-0.029707704,
0.018018996,
-0.04425949,
-0.0039564306,
-0.0004214994,
0.0018271813,
0.0012066292,
-0.012982345,
0.0070526246,
0.0029894854,
-0.0087271305,
0.013619314,
-0.0050071008,
0.018439265,
-0.014880118,
0.005450352,
-0.01733606,
-0.029418768,
0.035276257,
-0.005161418,
0.013048012,
0.037981734,
0.004320882,
0.0093837995,
0.025294889,
0.0094823,
-0.005933004,
0.0022211827,
0.007111725,
0.015943922,
-0.016062122,
-0.008963531,
-0.0061365715,
-0.014026449,
-0.009646467,
-0.0009176949,
0.00856953,
-0.025938423,
0.016797591,
0.004153431,
0.01063147,
0.065351695,
-0.0028548683,
-0.010670871,
-0.0040253806,
-0.023837082,
0.0030633607,
0.025636356,
-0.024375552,
0.020186003,
0.0016482391,
-0.006954124,
0.035670258,
0.019923337,
-0.016232856,
-0.022484345,
0.010585504,
0.004826517,
0.030915974,
0.017047126,
0.009114565,
-0.0069803908,
0.031730242,
0.026214225,
0.0072890255,
0.011419473,
-0.007118291,
-0.01434165,
-0.028972235,
0.024822086,
-0.010723404,
-0.022326745,
-0.02269448,
0.015169052,
0.0014692968,
0.003457362,
0.00089717394,
0.0019617984,
0.013698114,
0.015024586,
0.0006710336,
0.019686935,
0.01259491,
0.0025019087,
-0.0192404,
0.036668394,
0.028578233,
0.004045081,
-0.014827585,
0.023797683,
-0.015720654,
0.018754466,
-0.018242264,
0.02021227,
0.006123438,
0.030863442,
-0.02265508,
0.012102408,
-0.005112168,
-0.0014011674,
0.029707704,
0.042499613,
0.0020405988,
0.021801408,
0.022431811,
-0.027606362,
-0.024848353,
0.008759964,
-0.023705749,
-0.020540604,
0.00058771874,
0.0070985914,
0.008694297,
0.004038514,
-0.008142695,
-0.01803213,
-0.02402095,
-0.009869735,
-0.0034212451,
-0.004882334,
-0.015865121,
0.018491797,
0.006152988,
0.014709384,
-0.025702022,
-0.018255398,
0.011123972,
0.005962554,
0.013172779,
-0.012187776,
0.025636356,
-0.015103386,
0.008700863,
-0.0021702908,
-0.012949511,
-0.010979505,
-0.017677529,
-0.004885617,
0.00049783714,
0.018912066,
-0.001317442,
0.064878896,
0.007164258,
-0.0017500228,
0.0017450977,
-0.031966645,
0.012719678,
0.03296478,
0.010578937,
-0.010079868,
-0.034540787,
0.0052336515,
-0.0122337425,
-0.01713906,
-0.026043491,
-0.018373597,
0.02794783,
-0.03774533,
0.0043274486,
-0.011380073,
0.03648453,
0.018163463,
-0.010559237,
0.020842673,
0.011334106,
-0.034987323,
0.0036839128,
0.015366053,
-0.0075976597,
0.0056243697,
-0.008162395,
0.0045769825,
-0.012378209,
-0.019568734,
0.0026874177,
0.00027395407,
0.013763782,
-0.006392672,
-0.032833446,
0.03046944,
0.014932652,
-0.011176505,
0.0065010227,
-0.019726336,
-0.0011787207,
-0.015628722,
0.0073087253,
-0.018124063,
-0.0105067035,
-0.015563054
] |
Molecular motors play critical roles in the formation of mitotic spindles, either through controlling the stability of individual microtubules, or by crosslinking and sliding microtubule arrays. Kinesin-8 motors are best known for their regulatory roles in controlling microtubule dynamics. They contain microtubule-destabilizing activities, and restrict spindle length in a wide variety of cell types and organisms. Here, we report an antiparallel microtubule-sliding activity of the budding yeast kinesin-8, Kip3. The in vivo importance of this sliding activity was established | [
-0.028168587,
-0.014403484,
-0.0006076262,
-0.0051369765,
-0.028673973,
0.022835441,
-0.012541538,
0.022556148,
0.005479442,
-0.028434578,
0.018978553,
0.026027348,
0.021585276,
0.0011246487,
-0.0138582,
0.010805938,
0.030988105,
0.0057088602,
0.0028461178,
0.0042691766,
-0.023367425,
0.025003279,
-0.0076007308,
-0.04362274,
-0.010147607,
0.018247074,
0.014456683,
-0.03678674,
-0.0072150417,
-0.031067902,
-0.003100473,
-0.007899972,
0.0019733305,
0.006659783,
-0.004944132,
-0.008052917,
0.020268615,
-0.012069401,
0.009608973,
0.007979769,
-0.0018519715,
0.013977896,
-0.015361057,
-0.012933876,
-0.0071817925,
0.005569214,
0.014629577,
0.0019916175,
0.004405498,
0.005273298,
0.0066963565,
0.0148955695,
-0.038010303,
0.0062075956,
-0.002703147,
-0.030615715,
0.02149218,
0.0065966095,
-0.013592208,
-0.0086779995,
-0.008731198,
0.006895851,
-0.0061909715,
0.0060081016,
-0.0018918704,
0.014802473,
0.008604852,
-0.0026250116,
0.0146428775,
-0.002412218,
0.015374356,
0.016691018,
0.0074344855,
0.00099664,
0.02356692,
-0.04577728,
-0.020587806,
-0.0015494053,
-0.009974712,
0.028248385,
0.0021794746,
-0.00014037329,
0.0058618058,
0.014456683,
0.005359745,
-0.015361057,
0.014576379,
0.0038236396,
-0.0019999298,
0.008717898,
0.01629203,
0.038994472,
0.023194531,
0.015520652,
-0.016371828,
0.022755643,
-0.016877213,
0.023766413,
-0.021904469,
0.00015273778,
0.00081044534,
-0.009382879,
-0.0056689614,
-0.02044151,
-0.012767632,
-0.0065833097,
0.019364242,
-0.025748057,
0.016079236,
-0.013253068,
-0.03846249,
0.008179264,
0.008013018,
-0.031972278,
0.0066797324,
0.0072948392,
0.013412663,
-0.0030572491,
-0.0008037955,
-0.0076339794,
0.021771472,
0.039366864,
0.0028444554,
-0.016957011,
0.038409293,
0.0032983047,
-0.0017954481,
0.0023307577,
-0.0050505293,
-0.02248965,
0.01488227,
0.014735974,
0.0077071274,
0.010992133,
-0.033754427,
0.0095424745,
-0.015161563,
-0.01662452,
-0.01144432,
-0.03386082,
0.001151248,
0.021226186,
-0.01665112,
-0.0077270768,
0.010553245,
-0.013831601,
0.017794887,
0.022103962,
0.004405498,
0.008259062,
0.016345229,
-0.009256532,
0.015547251,
0.008458556,
0.014376885,
-0.019949423,
0.008225813,
-0.008784397,
-0.024564391,
-0.014922169,
-0.0075009833,
0.005233399,
0.023513721,
-0.0061843214,
0.021279385,
0.025561862,
-0.012501639,
0.008086166,
0.005821907,
-0.023447223,
0.009515875,
0.0052533485,
-0.03973925,
0.012348694,
-0.014988667,
0.006264119,
0.023114733,
0.016159033,
-0.03146689,
0.0046847896,
0.002350707,
-0.0019367565,
0.027955793,
0.0030323125,
-0.012162499,
-0.01456308,
0.0140842935,
-0.016996909,
0.014137492,
-0.010360401,
-0.003427976,
-0.0121093,
-0.002096352,
-0.010273953,
-0.63114655,
-0.027982391,
0.029418752,
-0.030163528,
-0.0030173503,
0.022556148,
0.021239487,
0.021984266,
0.00077511824,
0.010972183,
-0.005396319,
0.01907165,
0.0138582,
-0.033834223,
-0.024391497,
-0.036866535,
0.0017638616,
-0.025428865,
0.013698605,
-0.009894914,
-0.008797696,
0.013133371,
-0.0022044114,
0.0077004777,
0.005612438,
-0.009968062,
0.049926758,
-0.0010822562,
-0.009509225,
0.040936217,
-0.016677719,
0.020308513,
-0.025721457,
0.008032968,
0.0380901,
0.009303082,
-0.016704317,
0.025149575,
0.020827198,
0.03992545,
-0.033727825,
-0.009642222,
0.014696076,
-0.013632107,
0.01798108,
0.005645687,
0.016026037,
-0.01107858,
0.009070338,
-0.019577036,
-0.009269833,
0.02254285,
-0.018060878,
-0.0044254474,
-0.009456027,
0.0030688865,
0.019656833,
-0.022662546,
-0.016558021,
0.008039618,
-0.003170296,
0.01110518,
-0.011530767,
-0.016491523,
-0.0208006,
0.011570666,
-0.019616934,
0.005250023,
0.013452562,
0.006131123,
0.023074834,
0.0151482625,
-0.0027280836,
0.00346455,
0.005678936,
0.018433267,
-0.00095092255,
-0.013472511,
-0.00081626396,
0.012056102,
0.0015186499,
0.0029658144,
-0.039686054,
-0.0061477474,
0.034711998,
0.008784397,
-0.031919077,
0.016172333,
0.0146428775,
0.0073014894,
0.025827855,
-0.0075009833,
0.005775358,
-0.040989418,
-0.033701226,
0.028993163,
-0.021093192,
-0.0023523695,
0.021093192,
-0.016837314,
-0.014656177,
0.012342043,
-0.0075807814,
-0.0010257328,
0.025016578,
0.011856608,
-0.03157329,
0.020986794,
0.0137784025,
-0.038568888,
0.010905685,
-0.00062466634,
-0.0067695044,
-0.0148955695,
0.009569074,
-0.023287628,
0.010998783,
0.004471996,
0.0029109535,
-0.029205957,
-0.014124192,
-0.0065633603,
-0.0036141707,
-0.0043389997,
0.00364077,
0.0007630655,
0.018632762,
-0.008844244,
-0.0048044864,
-0.021944366,
-0.0021528753,
0.00381034,
0.033914022,
-0.004023134,
0.01838007,
0.025681559,
0.0015510677,
0.011224876,
0.009755269,
-0.013572258,
-0.038675282,
-0.026692329,
-0.0095424745,
-0.001099712,
0.02038831,
-0.029711341,
-0.041095812,
-0.0035044488,
0.011923105,
0.0056656366,
-0.012029503,
0.011484219,
0.00019970204,
0.024032407,
0.026798727,
-0.0044287723,
-0.040191438,
-0.019497236,
0.0065833097,
-0.016145734,
-0.0005028917,
-0.0132198185,
-0.018885454,
0.026452936,
-0.012647935,
-0.017050108,
0.02840798,
-0.02045481,
-0.012980425,
-0.027929194,
-0.0015136625,
-0.011869907,
-0.031626485,
0.0038269644,
0.007075396,
0.018805657,
0.0059150043,
0.009841716,
-0.0022675844,
-0.0052433736,
-0.0071418937,
-0.031014705,
-0.018446567,
-0.007760326,
0.040085044,
0.019231245,
0.03183928,
-0.0031686334,
0.003155334,
0.02006912,
0.0063871406,
0.009422778,
0.021571977,
-0.004043083,
-0.0035709469,
-0.0108591365,
0.014469982,
0.019191345,
-0.005259998,
0.019124849,
0.031493492,
-0.013572258,
-0.020135619,
-0.026466236,
0.008957291,
-0.015334457,
-0.00692245,
-0.024524491,
0.014217289,
0.0027929193,
0.000797977,
0.0009999649,
-0.00042143158,
0.002872717,
0.017435797,
-0.0011961343,
-0.029418752,
-0.0049042334,
-0.02391271,
-0.013199869,
-0.01456308,
-0.008917392,
0.01905835,
0.0038169897,
-0.010706191,
0.008139365,
0.008032968,
0.02010902,
-0.014057694,
0.0046482156,
-0.024444694,
-0.01349911,
0.000048730624,
0.014935469,
0.006383816,
0.009589023,
0.005233399,
0.0063206423,
0.059582278,
-0.007454435,
0.017621992,
0.010892386,
-0.0012476703,
0.0069490494,
0.012867378,
-0.0026532733,
0.033435233,
0.0046548657,
0.015294558,
-0.00016125785,
-0.000985834,
0.0028494427,
-0.03500459,
-0.011025381,
-0.0242319,
-0.024830382,
0.015693547,
-0.0005390501,
0.030535918,
0.023394024,
-0.007547532,
-0.0054262434,
0.008684649,
-0.022064064,
0.0032983047,
0.002673223,
0.014297088,
0.004787862,
-0.016850613,
-0.00066581205,
-0.012395242,
0.023128033,
0.028567575,
-0.013479161,
0.032052074,
0.0061144982,
0.01454978,
0.018433267,
0.009668821,
0.027902594,
-0.0038036902,
-0.047320034,
0.008338859,
0.0046581905,
-0.01490887,
-0.027929194,
-0.012342043,
0.0173028,
0.0056290627,
-0.0011612227,
0.006968999,
0.008259062,
0.005223424,
0.013572258,
-0.012574787,
-0.02110649,
0.025056476,
-0.011045331,
0.033515032,
-0.0021711623,
0.0018602838,
-0.011391121,
-0.0075076334,
-0.0019417439,
0.039579656,
0.022090662,
0.0021462254,
-0.012009554,
-0.018193875,
-0.021997565,
0.0039699352,
-0.0074477848,
-0.01800768,
-0.010679591,
-0.021718273,
0.014283787,
0.035536572,
-0.0018968577,
0.040750023,
-0.015041865,
-0.018140676,
-0.0113445725,
0.0008678,
0.008937342,
0.03984565,
0.02250295,
0.007687178,
0.019217946,
0.009748618,
0.02179807,
-0.0036507447,
-0.01943074,
0.018818956,
-0.030642316,
0.005502716,
-0.02944535,
0.002211061,
0.0014313712,
-0.0025535263,
0.00830561,
-0.014070994,
0.0041727545,
-0.005811932,
0.0011138428,
0.031014705,
0.005788658,
0.024138803,
0.053517655,
0.0029624894,
0.009163436,
-0.008724548,
0.02909956,
0.007514283,
-0.022702444,
0.008884143,
-0.004189379,
0.01524136,
0.011404421,
-0.019776529,
-0.041441604,
0.0014604641,
0.033195842,
0.002891004,
0.028673973,
0.016119136,
0.01178346,
-0.0018586214,
-0.009908214,
0.008112766,
-0.032078672,
0.012927227,
0.009728669,
-0.008139365,
-0.00005340627,
0.03702613,
-0.01770179,
-0.011025381,
-0.02147888,
0.017635291,
-0.007514283,
-0.0033747775,
0.0022010864,
-0.012960476,
-0.024351597,
0.004724689,
-0.019537136,
0.001838672,
-0.005685586,
0.0027131217,
0.0039998596,
-0.0067362557,
-0.016079236,
-0.035536572,
-0.018326871,
0.0077669756,
-0.027171116,
-0.05056514,
-0.005855156,
0.003770441,
0.027742999,
0.006403765,
-0.036494147,
-0.0151482625,
0.024883581,
-0.010187506,
0.011151728,
0.0032850052,
-0.0346588,
-0.00030256627,
0.018167276,
0.037930503,
0.022755643,
0.0055326405,
-0.020401612,
0.013751803,
-0.01453648,
0.011457619,
-0.006709656,
-0.010899035,
0.0016333591,
0.017262902,
0.044926103,
-0.013711904,
-0.017395899,
-0.007367987,
-0.03886148,
-0.009562424,
-0.024883581,
-0.016571322,
-0.018845556,
0.000052678948,
0.010759389,
0.01453648,
0.012621336,
-0.017887983,
-0.027530205,
-0.0054561673,
-0.025109675,
0.006004777,
0.035775967,
0.004568418,
0.023433924,
-0.026878525,
0.0014189028,
-0.0121093,
-0.013618806,
0.022768943,
-0.003959961,
-0.014935469,
0.020188818,
-0.009023789,
-0.016491523,
-0.0066963565,
0.009755269,
-0.009589023,
0.0450857,
-0.012514939,
-0.026559332,
-0.00329498,
-0.008259062,
-0.015041865,
-0.008757797,
0.016145734,
0.012056102,
-0.008531704,
-0.0001435943,
-0.0040962817,
-0.0029541773,
0.027875995,
-0.031307295,
-0.021026693,
0.047027443,
0.005296572,
0.011923105,
-0.01142437,
0.013332865,
-0.018047579,
-0.004445397,
-0.016105834,
-0.041468203,
-0.011184977,
0.011663763,
0.044500515,
0.023926008,
0.028195186,
0.0034479254,
-0.0035443476,
0.01145097,
0.011138428,
-0.015853142,
0.0047346633,
0.01834017,
-0.03194568,
0.016850613,
0.020215416,
0.02909956,
0.016850613,
0.0009384542,
0.010699541,
0.018646061,
-0.015055166,
-0.023726515,
-0.008438607,
-0.022409853,
-0.01834017,
0.008418657,
-0.025375668,
-0.018872155,
-0.026173644,
-0.011251475,
0.0073746373,
0.017794887,
0.00037883126,
0.005509366,
0.010879086,
-0.0154541535,
0.022582749,
-0.01110518,
0.0057354593,
-0.024537792,
-0.0008037955,
-0.01594624,
-0.0069357497,
0.022409853,
-0.0036474196,
-0.0010107708,
0.0063771657,
-0.0054628174,
-0.015161563,
0.0058684554,
-0.015294558,
-0.009968062,
-0.018326871,
-0.030908307,
-0.012268896,
-0.019204646,
-0.026333239,
-0.03500459,
-0.0054295682,
0.0058717807,
-0.00795982,
0.01627873,
-0.018685961,
-0.008884143,
0.022702444,
0.006104524,
0.012953826,
-0.005848506,
0.021944366,
0.005808607,
-0.0032999672,
0.009562424,
-0.044580314,
-0.0044886204,
0.0074012363,
0.015520652,
0.029179357,
-0.015214761,
-0.018912055,
0.0022310107,
-0.021186288,
0.0012784256,
-0.028806968,
0.0010988808,
-0.004385548,
0.005063829,
0.00013663278,
0.013618806,
-0.01770179,
0.034020416,
-0.0004762925,
0.013366114,
0.0023357451,
-0.003215182,
-0.009615622,
0.009396179,
0.014323686,
0.023074834,
-0.00042330186,
-0.010433549,
0.024364896,
-0.0061942963,
-0.008358808,
0.012348694,
-0.015560551,
0.028461179,
-0.008737848,
0.013259717,
0.003276693,
0.010067809,
-0.010752739,
-0.012202398,
-0.003707268,
0.04056383,
-0.014097593,
0.0043921983,
0.014802473,
-0.01244844,
0.01973663,
-0.016558021,
0.0011013745,
0.005140302,
-0.022622647,
0.003707268,
0.018140676,
0.010200806,
0.019204646,
-0.038834877,
-0.024338298,
-0.0021611876,
0.0054229186,
-0.016677719,
0.020055821,
-0.05061834,
-0.020547906,
-0.018087478,
0.028700572,
0.009229934,
0.0041062566,
-0.020375011,
-0.026053948,
0.04048403,
-0.006786129,
0.031094503,
-0.016238831,
-0.013831601,
-0.028860167,
0.0058784303,
0.0010581507,
-0.03920727,
-0.0115440665,
0.0015660297,
-0.03080191,
0.02389941,
-0.012022853,
0.027849397,
0.008691299,
-0.003354828,
0.0076073804,
0.008618151,
0.013545659,
0.0035044488,
-0.011683713,
0.00061552285,
-0.033701226,
-0.015081764,
0.020880397,
-0.032131873,
-0.03912747,
0.0092365835,
-0.023726515,
-0.017116606,
-0.023872811,
-0.012375292,
-0.025335768,
-0.01901845,
-0.013273017,
-0.00042226282,
0.019231245,
-0.03418001,
-0.0081194155,
-0.0030655614,
0.012993725,
-0.007860073,
-0.004368924,
-0.02356692,
0.00762733,
0.011397771,
-0.01940414,
-0.006683057,
0.009728669,
-0.0276898,
-0.02875377,
-0.004289126,
-0.002114639,
0.03215847,
-0.013066873,
0.0018153976,
-0.00798642,
-0.009901565,
-0.032796852,
-0.033275638,
0.03699953,
-0.0018769084,
0.009469327,
-0.0001950264,
-0.0014671138,
-0.0041029314,
0.0108591365,
0.015440854,
0.017262902,
-0.019337641,
0.026865225,
-0.01799438,
-0.0006097043,
-0.004471996,
-0.019284444,
0.0101010585,
0.041122414,
-0.007175143,
-0.006453639,
0.014696076,
0.015813243,
-0.0077071274,
0.0023157957,
0.009123537,
-0.00010618912,
0.02878037,
0.03540358,
-0.039712653,
-0.021319285,
0.010666292,
-0.015467454,
-0.009535825,
0.010347101,
-0.006031376,
0.006347242,
0.021026693,
0.0021694999,
-0.017555494,
0.00168822,
-0.017409198,
0.021399083,
0.017156504,
0.033781026,
0.019843027,
0.024351597,
-0.01317327,
-0.0038535637,
0.0030422872,
-0.018898755,
-0.0063272924,
0.010566545,
0.007341388,
-0.0038834878,
0.016863912,
-0.017209703,
-0.0044520465,
-0.006151072,
0.012707783,
0.004784537,
-0.02356692,
0.007833473,
-0.0065633603,
-0.0056822607,
-0.011510817,
0.011118479,
-0.0044553713,
-0.03008373,
0.0070421468,
-0.011803409,
-0.022250257,
0.014842371,
0.0130203245,
-0.008352159,
0.01349246,
-0.010752739,
0.0048776343,
-0.022635946,
0.021651775,
0.18427949,
-0.018991852,
0.010819238,
0.027929194,
-0.0032983047,
-0.0154541535,
-0.00053530955,
-0.007793575,
-0.022316756,
-0.022596048,
0.027875995,
-0.004741313,
-0.0049042334,
-0.0052134497,
0.019856326,
-0.0079398705,
-0.019882927,
-0.021970965,
-0.00899054,
0.003063899,
-0.003677344,
-0.02459099,
0.012681184,
0.017781587,
0.029312354,
0.00899054,
-0.02594755,
-0.010752739,
-0.01076604,
0.0060779247,
-0.018725859,
-0.011371172,
0.009808467,
-0.0037006182,
0.014829072,
-0.016770815,
-0.0068493024,
-0.00043556243,
0.011178328,
0.010500046,
0.0049408074,
-0.013292966,
0.015028566,
-0.004285801,
0.01177016,
0.017090006,
-0.0075342325,
-0.0019500562,
-0.0010265642,
-0.000031794396,
-0.06979638,
-0.004222628,
0.024684086,
0.031307295,
-0.010074459,
0.003770441,
0.019962724,
0.024059005,
-0.00294254,
0.035802566,
-0.02326103,
-0.012614686,
-0.030908307,
0.0207607,
-0.021053292,
0.019523837,
-0.025029877,
-0.0010348763,
0.026772127,
-0.0173161,
-0.012175798,
0.014709376,
-0.01630533,
0.0072948392,
0.012255596,
-0.018326871,
0.029897537,
0.009170085,
0.021731572,
0.016238831,
-0.013073523,
-0.009901565,
-0.0242585,
-0.027091319,
0.013239767,
-0.020375011,
0.018286971,
-0.0019849676,
-0.00728154,
0.0060014515,
-0.007075396,
-0.019616934,
0.0173294,
-0.020348413,
0.004505245,
-0.009050389,
0.014616278,
-0.0068027535,
-0.016903812,
-0.018047579,
-0.02875377,
0.07038157,
0.011437669,
0.0040630326,
-0.0069756485,
0.0010955558,
0.0152014615,
-0.020348413,
-0.026519435,
-0.033701226,
0.021598576,
-0.040643625,
0.01143102,
-0.008578252,
-0.023061534,
-0.000113150636,
0.024431394,
-0.017036809,
0.03503119,
-0.010526646,
-0.011524118,
-0.01625213,
0.01071949,
0.0031802708,
-0.004422122,
0.01145097,
-0.054129437,
0.009163436,
-0.00589173,
-0.010672942,
-0.0038003654,
0.0035576473,
-0.020667603,
0.012621336,
-0.020242015,
-0.0064868876,
0.003373115,
-0.017502295,
0.016225532,
-0.0207474,
-0.006988948,
0.0017372624,
0.009788518,
0.015893042,
0.010972183,
-0.0154541535,
0.010533296,
0.047426432,
-0.0067628548,
-0.046176266,
0.0074477848,
-0.014323686,
-0.007414536,
-0.019550435,
0.014044395,
0.008199213,
-0.001386485,
-0.027636603,
0.0011445982,
0.012521588,
-0.035057787,
0.01803428,
0.011457619,
0.014775873,
0.0051768757,
-0.013193219,
-0.1665112,
0.0026250116,
0.0036307953,
-0.015720146,
0.018566264,
0.026878525,
0.008757797,
-0.0040364335,
0.003537698,
0.0005203475,
0.013086822,
-0.0015951227,
-0.042372577,
-0.022835441,
0.012049452,
0.014722675,
-0.006410415,
0.026373139,
0.021026693,
0.0013174933,
0.023819612,
-0.023154631,
-0.006104524,
-0.014669476,
-0.01869926,
0.032637257,
-0.001316662,
0.0013548983,
0.011204926,
-0.018127376,
0.004990681,
0.016757516,
0.045537885,
0.003130397,
0.02145228,
0.019204646,
-0.02702482,
-0.00674623,
-0.013459211,
0.036573943,
0.032424465,
0.027556805,
0.012242297,
-0.013140021,
0.03154669,
0.032796852,
-0.019683432,
0.0014729325,
0.0074677346,
-0.01907165,
0.036919735,
0.009981362,
0.02185127,
0.023473822,
0.016531423,
0.012308795,
-0.0006828522,
0.030402923,
-0.006895851,
0.00016738813,
-0.0082457615,
-0.006031376,
0.019630233,
-0.0242319,
-0.010839187,
-0.020521307,
-0.0021013394,
0.024125503,
-0.019324342,
0.02391271,
-0.037371922,
0.027237613,
0.002842793,
-0.010187506,
0.011504168,
0.008252412,
0.007454435,
0.012667884,
-0.014802473,
0.0042425776,
-0.04295776,
0.033062845,
-0.02631994,
-0.028008992,
0.004292451,
0.018885454,
-0.0033498409,
0.006264119,
0.010519996,
0.02010902,
0.011617214,
-0.009163436,
0.0019301068,
-0.0039400114,
0.022981737,
0.022197058,
-0.019577036,
-0.02320783,
-0.0014754261,
-0.013698605,
0.008412007,
-0.012069401,
-0.008611501,
0.030402923,
0.025468765,
0.018140676,
-0.003048937,
0.011005432,
0.02734401,
0.010692892,
-0.0017372624,
-0.012355343,
0.017848086,
0.040324435,
-0.00190517,
0.036547344,
0.00972202,
0.014137492,
0.0075209327,
-0.008252412,
0.04947457,
-0.024803784,
-0.019537136,
-0.0013141683,
0.006616559,
-0.018326871,
-0.12576117,
-0.013100122,
0.007540882,
0.030349724,
-0.026825326,
0.008777747,
-0.008850895,
0.03332884,
0.01454978,
0.021266086,
-0.011963004,
-0.00024417264,
-0.000087694345,
-0.0073879366,
-0.026785426,
-0.0207607,
0.013133371,
-0.021252787,
-0.027663201,
0.022702444,
-0.0130934715,
0.014017795,
-0.011916456,
-0.0012401892,
0.019457338,
-0.0028278308,
-0.019537136,
0.029977335,
0.014988667,
0.007806875,
-0.019683432,
-0.006756205,
0.032690458,
-0.014044395,
-0.006274094,
-0.024763886,
-0.007527583,
-0.035563175,
0.026705628,
-0.000787171,
0.0099215135,
0.0010648005,
0.039765853,
0.011391121,
0.015214761,
-0.015999438,
-0.0031603212,
0.02320783,
-0.019470638,
0.009110237,
-0.031254098,
-0.0030788612,
-0.03771771,
-0.02250295,
0.019191345,
-0.010367051,
0.016345229,
0.023766413,
-0.017063407,
-0.00047546127,
-0.026040649,
0.0025551887,
0.02149218,
0.0052566733,
0.009475976,
-0.016917111,
0.0045983423,
-0.035589773,
0.022569448,
-0.039340265,
-0.014935469,
0.0016242156,
-0.022409853,
-0.010207456,
-0.023513721,
0.0011213239,
-0.025375668,
-0.016132435,
0.004056383,
0.0067063314,
-0.019843027,
-0.025548562,
0.017582092,
-0.017236302,
0.0416278,
-0.008458556,
-0.005752084,
0.005333146,
0.017223002,
-0.00079382083,
0.0019384191,
0.04085642,
-0.012388593,
-0.0138582,
-0.017063407,
0.024830382,
-0.02835478,
0.007840124,
0.004777887,
0.0071950923,
-0.028328182,
-0.0013881475,
-0.05229409,
0.009462677,
0.025335768,
0.013725203,
-0.0054993914,
0.0034878242,
0.0276898,
0.0055991383,
0.004422122,
0.019989323,
-0.019417439,
-0.0019101574,
0.019869626,
-0.011111829,
-0.03702613,
-0.03250426,
0.029418752,
-0.03394062,
0.014230589,
0.02526927,
0.0112182265,
-0.008099467,
0.01943074,
0.03292985,
-0.0028112063,
-0.012175798,
-0.016597921,
0.016132435,
-0.017941182,
0.006586635,
0.019191345,
-0.017808186,
0.0040962817,
-0.00078135246,
-0.0033215792,
0.01071949,
-0.009535825,
0.032690458,
0.021505479,
0.021558678,
-0.0057088602,
-0.03952646,
-0.013253068,
-0.006284069,
-0.022689145,
0.007806875,
-0.016185632,
0.00072940084,
-0.013738504,
-0.008711249,
0.010001311,
0.01766189,
-0.011577316,
-0.054900814,
0.003427976,
0.0072881896,
0.004225953,
-0.01420399,
0.0021063266,
-0.01561375,
0.0077403765,
0.014935469,
-0.002478716,
0.0058285566,
-0.0050704787,
0.003052262,
-0.017422497,
-0.008146015,
-0.0022060738,
-0.04601667,
-0.0103737,
0.029471949,
0.013193219,
0.008618151,
-0.0277164,
-0.004468671,
-0.021226186,
-0.009835066,
0.0016632832,
0.0073613375,
0.019949423,
0.015560551,
-0.025521964,
0.000787171,
0.029844338,
-0.0021977616,
0.012581437,
0.053491056,
-0.0051137023,
-0.0037338673,
-0.0013548983,
0.013977896,
-0.0034180013,
0.006683057,
0.009116887,
0.009555774,
-0.02981774,
-0.005296572,
0.019364242,
0.011570666,
-0.0004245487,
-0.005230074,
0.0027447082,
-0.022064064,
0.014297088,
0.031200899,
-0.031280696,
-0.006101199,
-0.009928163,
-0.014855671,
0.018366769,
-0.0028660672,
-0.007554182,
-0.010513347,
-0.012581437,
0.013658706,
-0.00622422,
-0.026745528,
-0.005895055,
0.018513065,
0.01282083,
0.020574506,
-0.014323686,
-0.019523837,
0.021026693,
-0.010360401,
0.015507353,
-0.028620774,
0.012022853,
-0.012262246,
0.04223958,
-0.008099467,
-0.049634166,
-0.00970207,
0.01597284,
-0.00969542,
-0.012854079,
0.0002464585,
-0.0051569263,
0.07644619,
0.003391402,
-0.010965534,
0.0066730822,
-0.0050738035,
-0.00023752284,
0.0207873,
0.0035709469,
-0.018898755,
-0.01766189,
0.001195303,
-0.01177016,
0.01038035,
-0.009396179,
0.0119031565,
0.029604945,
-0.0143369865,
0.0019201321,
-0.0036274702,
-0.016052637,
0.009203334,
-0.010094409,
0.01661122,
0.0277696,
0.00034953054,
0.0010431886,
0.022024164,
0.0115972655,
0.012062752,
-0.03880828,
0.0038967875,
-0.009788518,
-0.057241548,
-0.01629203,
0.011524118,
0.0025917627,
-0.012900627,
-0.021425681,
0.027197715,
0.0053065466,
0.0023590194,
-0.006613234,
-0.0065101623,
-0.017382598,
0.0018818957,
0.013206519,
0.01211595,
-0.005442868,
-0.024444694
] |
Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse panel of PI3-K inhibitors was synthesized, and their target selectivity was biochemically enumerated, revealing cryptic homologies across targets and chemotypes. Crystal structures of three inhibitors bound to p110gamma identify a conformationally mobile region that is uniquely exploited by selective compounds. This chemical array was then used to define the PI3-K iso | [
-0.016648563,
-0.01848673,
0.0037354226,
-0.03114384,
-0.015335584,
0.051941413,
-0.02696857,
0.008547488,
-0.018670548,
-0.034478806,
0.04490385,
0.0047595454,
-0.010825505,
-0.0014680736,
-0.020797573,
0.018316044,
0.014127644,
-0.016582914,
-0.010490695,
0.003443285,
-0.019970397,
0.024080018,
-0.0115082525,
-0.021861086,
-0.011094665,
0.020548107,
-0.0025045057,
-0.036632087,
-0.021703528,
-0.021440933,
0.0050451183,
-0.010385657,
-0.018998792,
0.019077571,
0.00043082092,
-0.007424891,
0.013681231,
-0.007838479,
0.0037058806,
0.010050847,
0.0063384017,
0.0031133993,
0.0038207662,
-0.0031002695,
0.0048481715,
-0.004559316,
0.007950082,
-0.006272753,
-0.016635433,
0.036159415,
-0.00812077,
0.014784133,
-0.0047464157,
0.0010364321,
-0.0031281703,
-0.018000929,
0.008199548,
-0.004903973,
-0.00749054,
-0.01977345,
-0.017528256,
-0.021335894,
-0.016018333,
0.023160933,
0.025091011,
0.0022747344,
-0.010182145,
0.022031773,
0.02927941,
-0.02041681,
0.03952064,
0.014035735,
-0.017764593,
0.009020159,
0.03300827,
-0.013825659,
-0.027073609,
-0.018867495,
-0.0121187875,
0.01918261,
0.022215588,
-0.012506116,
-0.009781687,
0.022241848,
-0.0065484783,
0.0050188587,
0.011849627,
0.027283683,
0.013320163,
0.015900165,
0.02576063,
0.01727879,
0.010077107,
0.016307188,
-0.01916948,
0.015860775,
-0.009716038,
0.015020469,
-0.0031347352,
-0.026797883,
0.0012424055,
0.025484905,
0.017751463,
-0.018959403,
-0.044431176,
0.014823522,
-0.022819558,
-0.011724894,
0.02218933,
0.01433772,
-0.008022296,
0.04724095,
0.019248258,
-0.041148733,
0.030644909,
-0.017055586,
0.0084949685,
-0.0057574087,
0.0046643545,
-0.027178645,
0.015322454,
0.02578689,
-0.0022189328,
-0.02095513,
0.0023929025,
-0.002351872,
-0.007293593,
-0.019366426,
-0.026561547,
-0.0027506892,
0.015440622,
0.010090237,
0.017160624,
-0.021060169,
-0.0336385,
0.0023026352,
-0.025878798,
-0.0061611496,
-0.008186419,
-0.03366476,
0.0036763386,
0.026246432,
-0.007805655,
0.009341839,
0.011232527,
0.008521228,
0.03455758,
0.004303286,
-0.007188555,
-0.0003682493,
0.010576039,
0.01916948,
0.018066578,
-0.0010479207,
0.002573437,
0.016018333,
-0.005862447,
0.0128540555,
-0.0066108447,
-0.005343821,
-0.0007414223,
-0.008777258,
-0.008613137,
0.010772985,
0.051074848,
0.002543895,
0.01616276,
0.011337565,
-0.0019596198,
0.0040078657,
0.009610999,
0.02582628,
-0.023778033,
0.011770848,
-0.015781997,
0.0070900815,
0.03290323,
0.012026879,
-0.009998328,
0.0072148144,
0.01376001,
0.0043426747,
0.012617719,
-0.0016239898,
-0.009230236,
0.0001665841,
0.013996346,
-0.017593905,
0.006722448,
-0.011534512,
0.008166724,
0.008875731,
-0.024985973,
-0.028832998,
-0.62938917,
-0.024408262,
-0.00018894575,
-0.032535598,
0.024710247,
0.05146874,
0.029620785,
0.0019924443,
0.00024392671,
0.025839409,
0.0011176725,
0.0021171772,
0.017186884,
-0.020836962,
-0.04330202,
-0.04015087,
-0.003613972,
-0.034347508,
0.030382313,
-0.013589323,
0.006489394,
-0.011134054,
-0.0072213793,
0.010661382,
0.019983526,
0.015716348,
0.0026571394,
-0.027887654,
-0.009361533,
0.02927941,
-0.008842907,
0.027651317,
-0.009177716,
0.014088254,
0.04726721,
-0.014508408,
-0.00077506737,
0.027992692,
0.027940173,
0.033480942,
-0.010576039,
-0.0032053078,
0.023502307,
-0.000095037045,
-0.019550243,
0.025051622,
0.0017971387,
0.0053635156,
-0.0037058806,
-0.0049138204,
0.009315579,
-0.019038182,
-0.026535287,
0.006801226,
0.011180008,
0.0069062645,
0.0028015669,
-0.014048865,
-0.0066896235,
0.030408572,
0.009965504,
0.005439012,
-0.009696343,
-0.034006134,
-0.017987799,
0.025970707,
0.0019645435,
-0.008114205,
-0.005550615,
0.0050779427,
0.026784753,
0.015059859,
-0.0062858826,
-0.013602452,
0.00374527,
0.031065062,
0.030933764,
0.0021779023,
-0.007845044,
0.0021335895,
0.014272071,
0.0041457284,
-0.0563005,
-0.002639086,
0.032798193,
0.018145356,
-0.008915121,
0.01734444,
0.0062267985,
-0.007483975,
0.017764593,
-0.023200322,
-0.006236646,
-0.020692535,
-0.017436348,
0.012880315,
-0.006420463,
0.011180008,
0.01259146,
-0.01851299,
-0.03529285,
-0.0076284027,
-0.015624439,
0.0020219863,
0.007602143,
0.0033070636,
-0.008783823,
0.0092958845,
0.050470877,
-0.049420495,
0.007740006,
-0.014193293,
0.008219243,
-0.0023633605,
0.02331849,
-0.026889792,
0.033848576,
0.00003243979,
0.0056622177,
-0.029200632,
0.013602452,
0.00812077,
-0.000092729075,
-0.0032479796,
0.009689778,
0.020600626,
0.007661227,
0.0038174838,
0.0022156504,
-0.0023272536,
0.025235439,
-0.010405351,
0.011889016,
-0.016596043,
0.0091120675,
0.014258942,
0.010365962,
-0.0015936272,
0.015900165,
-0.01495482,
-0.023646735,
-0.031590253,
0.0023239711,
0.011462298,
-0.0049729045,
-0.023160933,
-0.011757718,
-0.015453752,
0.023607345,
-0.0066764937,
0.008179854,
0.011803673,
0.018434212,
0.006643669,
0.032062925,
-0.014718484,
-0.0072673336,
0.00492695,
-0.011232527,
-0.007497105,
-0.02455269,
-0.012532376,
-0.01977345,
-0.003833896,
-0.015007339,
-0.033323385,
0.014075125,
-0.004119469,
-0.02744124,
-0.03290323,
-0.01616276,
-0.000567863,
-0.044168584,
-0.0055112257,
0.0118758865,
0.041148733,
0.00064910355,
0.0102149695,
-0.0069587836,
0.0126111545,
0.0125652,
-0.028229028,
-0.02996216,
0.0115673365,
0.024631469,
0.013398942,
0.03828644,
0.0395469,
0.009433747,
0.040413465,
0.0027523304,
0.0023682842,
0.004821912,
0.006991608,
-0.0038076364,
0.0011332642,
0.036316972,
0.007930388,
-0.01561131,
0.035397887,
0.036710866,
-0.00058017217,
0.012184436,
-0.03762995,
0.009538786,
-0.028334066,
0.007431456,
-0.029095594,
0.013175735,
0.012000619,
0.0073264176,
0.012381383,
-0.027309943,
-0.01372062,
0.004454278,
0.014705354,
-0.031984147,
-0.016517265,
-0.015978944,
-0.016884899,
-0.003472827,
0.0013154399,
0.008547488,
-0.003840461,
-0.003590995,
-0.0059477906,
0.018657418,
0.017003067,
0.0056031337,
-0.007300158,
-0.031485215,
-0.0017971387,
-0.0063646613,
0.029568266,
0.009440312,
0.019432075,
0.019418946,
-0.006699471,
0.052519124,
-0.0064532873,
0.016530395,
0.02511727,
0.0043623694,
0.0007783498,
0.0021746198,
-0.008698479,
0.024355743,
0.008114205,
-0.018145356,
0.011527947,
-0.025524294,
0.00048949465,
-0.032588117,
0.011409779,
0.01229604,
-0.012768712,
0.023029635,
0.025589943,
0.02102078,
0.016005203,
0.00029952312,
-0.004171988,
-0.006302295,
0.003965194,
0.006472982,
0.018591769,
0.011442604,
-0.0036106897,
-0.013274209,
-0.0119481,
-0.021493452,
0.00038158425,
0.002742483,
-0.008101075,
-0.0014943331,
-0.0004858019,
-0.010878024,
-0.016491005,
0.006187409,
0.009309014,
-0.009374663,
-0.041673925,
0.015821386,
0.01790902,
-0.006016722,
-0.01848673,
-0.03053987,
0.009519091,
-0.007989472,
0.022307497,
-0.021926735,
-0.004237637,
0.009184281,
0.00014022195,
-0.035030253,
-0.037551172,
0.02163788,
-0.013497415,
0.004956492,
-0.005294584,
0.008580312,
-0.020246122,
-0.0014295048,
-0.004874431,
0.051153626,
0.011770848,
-0.0016707646,
-0.0033874835,
-0.010621993,
-0.0072082495,
0.0053405385,
0.0096044345,
0.015374973,
-0.01081894,
-0.01165268,
0.010044282,
0.0167536,
0.0024027498,
0.037551172,
0.0073329825,
0.0010651535,
-0.021440933,
-0.006105348,
0.0063449666,
0.020640016,
-0.008501533,
0.005271607,
0.030277275,
0.014035735,
-0.0032611093,
-0.013471155,
-0.0052913018,
0.024841545,
-0.005750844,
-0.009282755,
0.0023338185,
0.0040735146,
0.0040866444,
0.000050980478,
0.018814975,
-0.016871769,
-0.01495482,
-0.009322144,
-0.011219397,
0.02580002,
0.002455269,
0.030671168,
0.028911777,
0.018197875,
-0.006003592,
0.02335788,
0.032509338,
0.01165268,
-0.024276964,
0.0056655,
-0.012512681,
-0.0034235902,
-0.017147494,
-0.020101694,
-0.020127954,
0.0072870282,
0.028334066,
0.002898399,
0.012479857,
0.016267799,
0.0055374852,
0.0077465707,
0.009519091,
-0.012722758,
-0.017147494,
-0.0011234168,
0.012755582,
-0.021152077,
-0.0197078,
0.018631158,
-0.007306723,
-0.015978944,
-0.014311461,
0.0127949715,
0.004615118,
0.01372062,
-0.03187911,
0.008232373,
-0.035713002,
-0.0075758835,
-0.014876042,
-0.0061545847,
-0.022005513,
0.0013261079,
-0.016070852,
-0.013510545,
-0.016097112,
-0.034058653,
-0.001621528,
0.01853925,
-0.023384139,
-0.017541386,
-0.0075758835,
0.005212523,
-0.000050724037,
0.011455733,
-0.026771624,
-0.0030067198,
0.03059239,
-0.018276654,
-0.014403369,
0.00078122196,
-0.036001857,
0.006052829,
0.033192087,
0.005993745,
-0.013274209,
0.0004788267,
-0.004500232,
0.008041991,
-0.0065222187,
0.009525656,
0.0054291645,
-0.013523675,
0.0069193942,
0.026272692,
0.022097422,
-0.0061611496,
-0.011107794,
0.0011431115,
-0.016582914,
0.003797789,
-0.039678197,
-0.009190846,
-0.006246493,
0.01167894,
0.006820921,
0.0010315084,
0.009945809,
-0.0002186929,
-0.012184436,
0.0033530178,
-0.007976342,
0.0072673336,
0.011396649,
-0.0061217602,
0.025550554,
-0.015322454,
-0.026128264,
-0.023646735,
0.0012259933,
0.016701082,
0.01196123,
-0.025694981,
0.008901991,
0.0043984763,
-0.013812529,
-0.004690614,
-0.012775277,
-0.013878178,
0.043013163,
-0.008337411,
-0.003384201,
-0.000044774602,
0.017685814,
-0.013878178,
-0.008580312,
0.0075167995,
-0.0004870328,
0.0008854396,
-0.008947945,
0.013615582,
-0.014061995,
-0.010608863,
-0.034084912,
-0.027152386,
0.012158177,
-0.014180163,
0.0089282505,
-0.008035426,
0.0057180193,
-0.021900475,
-0.018723067,
-0.024316354,
-0.039126746,
-0.023410399,
-0.00091251975,
0.019983526,
0.056037903,
0.0029328647,
0.0055243555,
-0.0038142013,
0.025038492,
-0.0052617597,
-0.008987335,
-0.011587031,
0.0023551544,
-0.04603301,
0.030881245,
0.0052289353,
-0.02582628,
0.02580002,
-0.013129781,
0.027336203,
0.00479237,
-0.01622841,
-0.013891308,
-0.0035745827,
-0.025708111,
-0.02867544,
0.0024224445,
-0.02036429,
-0.011941535,
-0.03471514,
-0.00059207104,
-0.0021106123,
-0.018736197,
0.0081273345,
0.01680612,
0.008462144,
-0.029699564,
0.031458955,
0.011455733,
0.0197078,
-0.005737714,
-0.0005953535,
-0.000115090734,
0.015335584,
0.006673211,
0.022307497,
0.02393559,
0.016674822,
0.005635958,
-0.013254514,
0.023843681,
-0.01788276,
0.003715728,
-0.0022287802,
-0.029016815,
-0.0153093245,
-0.010864894,
-0.029253151,
-0.040439725,
-0.002875422,
0.0145740565,
-0.01789589,
-0.001526337,
-0.014324591,
-0.0138387885,
0.020246122,
0.009131762,
0.031406436,
-0.004874431,
0.026023226,
0.01561131,
0.029226892,
-0.017239403,
-0.015401233,
-0.015663829,
-0.0026801166,
0.036894683,
0.014521537,
-0.0084358845,
-0.014823522,
-0.0086197015,
0.023843681,
-0.026456509,
-0.038601555,
0.009551915,
-0.012867185,
-0.00076604064,
-0.0060955007,
-0.0010011458,
-0.016057722,
0.025550554,
0.007825349,
0.016005203,
-0.0021746198,
-0.007910693,
-0.012893445,
0.019983526,
0.00008995951,
0.01735757,
0.002145078,
-0.0084949685,
0.013280774,
-0.020246122,
0.015847646,
0.016871769,
-0.023160933,
0.015729478,
0.0040669497,
-0.002535689,
0.01789589,
0.018316044,
0.010123061,
-0.022136811,
-0.0072016846,
0.042908125,
-0.0018184746,
-0.004887561,
0.0358443,
-0.018105967,
0.008271762,
0.0031248878,
-0.0036960333,
-0.022648871,
-0.021480322,
0.0072673336,
0.02459208,
0.00238962,
0.0049860342,
-0.014114514,
-0.017777722,
-0.0019727496,
-0.034426287,
-0.012985353,
0.004969622,
-0.039179265,
-0.023252841,
-0.0287017,
0.027861394,
0.00957161,
0.015755737,
-0.0076546622,
0.0055407677,
0.02331849,
-0.018683678,
-0.013044437,
0.010464435,
-0.00810764,
-0.021099558,
0.0031084756,
-0.008508098,
-0.022911467,
0.024382003,
-0.02641712,
-0.024198186,
-0.0038273311,
-0.005724584,
0.019852228,
0.024815286,
-0.0102149695,
-0.0008320999,
0.012939399,
0.0067027532,
-0.0043426747,
-0.0046774843,
0.012000619,
-0.041542627,
0.0005612981,
0.013201995,
-0.022360016,
-0.014061995,
-0.0110749705,
-0.020889482,
-0.0019497725,
-0.0018562227,
-0.030749947,
-0.02396185,
-0.0014459171,
-0.0031757657,
0.0022238565,
0.02577376,
-0.014061995,
-0.022885207,
0.00058017217,
0.023581086,
-0.002978819,
-0.019642152,
0.014324591,
0.028465364,
-0.008750998,
-0.02039055,
-0.0035417583,
-0.0082520675,
-0.054777443,
-0.04605927,
0.009991763,
-0.027362462,
0.041122474,
0.009460007,
-0.029174373,
-0.01372062,
0.003266033,
-0.044956367,
0.001374524,
-0.01913009,
0.010208405,
-0.007674357,
0.011672375,
0.003082216,
0.010825505,
-0.01794841,
-0.012250085,
0.006062676,
-0.025511164,
0.0370785,
-0.01730505,
0.0057180193,
-0.007871304,
-0.024040628,
0.006525501,
0.04910538,
-0.0128540555,
0.0010265848,
0.041621406,
-0.026036356,
-0.0067421426,
0.007300158,
0.013891308,
-0.004004583,
0.034741398,
0.034872696,
-0.03306079,
0.0138387885,
0.013786269,
0.0004287694,
-0.006820921,
0.008567182,
-0.02275391,
-0.007936953,
0.0147578735,
0.00477924,
-0.02040368,
0.0014647911,
0.009217106,
0.018158486,
0.011915276,
0.012959094,
0.0048317593,
0.0006396665,
-0.017817112,
-0.010142756,
0.0056523704,
-0.010037717,
0.01620215,
0.013471155,
0.02696857,
0.01620215,
-0.007352677,
-0.012040009,
-0.017029326,
-0.013825659,
0.023239711,
0.01167894,
-0.011619856,
0.015663829,
-0.00029234277,
-0.003863438,
-0.009374663,
0.001902177,
-0.011285046,
-0.028307807,
-0.0019661847,
0.007365807,
-0.030723687,
0.003443285,
-0.0022665283,
-0.011258787,
0.006814356,
0.00747741,
-0.020482458,
-0.03581804,
0.024027498,
0.19369052,
-0.016425356,
0.02699483,
0.0055703092,
0.024933454,
0.011061841,
0.010018023,
-0.003008361,
-0.009912984,
-0.011501688,
0.037840027,
-0.0033645064,
-0.0075233644,
-0.003430155,
0.0028081317,
-0.0042507667,
-0.0046774843,
-0.011416344,
-0.0149416905,
0.015191156,
0.00057237636,
0.0016625585,
0.013930697,
-0.0033119873,
0.024355743,
0.020902611,
0.0008526151,
0.018211005,
0.011514817,
0.023646735,
-0.023791162,
-0.003797789,
-0.0020252687,
0.013201995,
0.0037583997,
-0.008849472,
-0.022346886,
-0.022071162,
0.013103521,
0.014679095,
-0.01166581,
0.014193293,
0.0145740565,
-0.018237265,
-0.0167536,
0.0012415849,
0.002168055,
0.003472827,
0.005448859,
0.0019776733,
-0.035424147,
-0.0045822933,
0.0358443,
0.013615582,
-0.021217726,
-0.007680922,
0.0090529835,
0.026837273,
0.004273744,
0.0108911535,
0.0036402317,
-0.005898554,
-0.016136501,
0.017383829,
0.00029808705,
0.030172236,
-0.015663829,
-0.0073461123,
0.0056819124,
-0.011331,
-0.014902301,
0.015703218,
-0.0053536682,
0.013031308,
0.007661227,
-0.021992384,
0.047398508,
0.021086428,
0.053175613,
0.011265351,
-0.0044805375,
-0.0019251541,
-0.018591769,
0.014061995,
-0.006361379,
-0.012814666,
0.04267179,
-0.011941535,
-0.017830241,
0.018171616,
0.010589168,
-0.0039422167,
-0.013602452,
-0.0006979299,
0.010169015,
-0.014613446,
-0.010234664,
0.014101384,
-0.015401233,
-0.026495898,
-0.0097882515,
0.07242387,
-0.011856192,
0.025642462,
-0.034741398,
-0.0017856502,
-0.004047255,
-0.004001301,
-0.0143902395,
-0.028859258,
0.00924993,
-0.029463228,
0.010405351,
0.0018020624,
-0.009873595,
0.024408262,
0.0008005063,
-0.013602452,
0.021480322,
-0.013996346,
-0.0075890133,
-0.027966432,
0.0055177906,
0.022346886,
0.01561131,
-0.0022222153,
-0.049210418,
-0.0052978666,
0.011718329,
-0.024999103,
0.001792215,
0.00009267779,
0.0127949715,
0.029069334,
-0.02520918,
0.007234509,
0.008895426,
0.018867495,
-0.0031462237,
0.0336385,
0.0039684763,
0.0024831698,
-0.012276345,
0.015532531,
0.011521382,
-0.019077571,
0.031091321,
0.015795127,
-0.0020285512,
-0.0018775587,
0.00037809665,
-0.027756356,
-0.009354969,
-0.011462298,
0.03369102,
-0.008114205,
-0.0019842382,
-0.00026156986,
0.009814511,
0.028832998,
0.003103552,
0.01498108,
0.025931317,
-0.005425882,
-0.020810703,
-0.0018020624,
-0.16343951,
0.00779909,
0.010530084,
-0.02699483,
0.030933764,
0.006515654,
0.029095594,
-0.007293593,
0.016136501,
-0.013786269,
0.019261388,
-0.005182981,
-0.01856551,
-0.04674202,
0.01853925,
0.012519246,
-0.009026724,
0.027835134,
0.0022517573,
-0.0024027498,
0.020823833,
0.0034793918,
0.008875731,
-0.0030034373,
-0.0027030937,
0.024657728,
-0.03177407,
-0.029804602,
0.0037058806,
-0.011573901,
-0.014140774,
-0.0007135215,
0.011527947,
0.013497415,
0.036605828,
-0.0008333308,
0.005980615,
0.008238938,
-0.017554516,
0.011291611,
0.023515437,
0.020193603,
0.006663364,
-0.010700772,
0.00027121202,
0.0063679437,
0.00210733,
-0.0065878676,
0.008061686,
-0.007050692,
0.0045035146,
-0.016582914,
0.006407333,
0.0026916051,
0.01734444,
0.01436398,
-0.0053930576,
0.014862912,
-0.0019235129,
-0.0061545847,
-0.033323385,
0.002675193,
0.031590253,
-0.018604899,
-0.0007479872,
-0.0023945437,
-0.002012139,
0.0029230174,
-0.028649181,
0.01134413,
-0.007109776,
-0.009958939,
0.0055998513,
-0.017383829,
-0.0018791999,
0.0041457284,
-0.008048556,
-0.004375499,
0.013110086,
0.029253151,
0.00094698544,
-0.008173289,
-0.03416369,
-0.026495898,
-0.00010657689,
0.0111406185,
-0.011436039,
0.006502524,
-0.004684049,
0.005130462,
0.014429629,
-0.02807147,
0.0003844564,
0.0009995046,
0.006390921,
0.01981284,
-0.012716193,
-0.017200014,
-0.010320008,
0.0005559641,
0.023830552,
0.015834516,
-0.00014504304,
0.008527793,
0.01680612,
0.008317716,
0.0043984763,
0.018723067,
0.033428423,
0.014600316,
-0.018683678,
-0.018788716,
-0.007352677,
0.019261388,
-0.029200632,
0.02510414,
-0.013024743,
-0.0013843713,
-0.009164587,
-0.03426873,
0.058506303,
0.010608863,
0.00864596,
0.02039055,
0.005714737,
-0.03702598,
-0.13581446,
-0.029463228,
0.01677986,
-0.0016075775,
-0.00083661324,
0.0024355743,
0.018749326,
-0.0058591645,
-0.009427182,
0.020285511,
-0.018906884,
-0.015072988,
-0.0012136841,
-0.009243365,
0.0018529403,
0.018302914,
0.010871459,
-0.019011922,
-0.010713901,
0.011698634,
-0.008705044,
0.018250395,
0.009722603,
0.0050385534,
0.0064401575,
0.00094124116,
-0.025891928,
0.017226273,
0.013917567,
0.01978658,
0.02092887,
-0.0028311089,
0.003952064,
0.008816647,
-0.019287648,
-0.005767256,
-0.0014155544,
-0.028780479,
0.059136532,
-0.00957161,
0.010641688,
0.0019185892,
0.022767039,
0.0070244325,
0.014101384,
-0.004697179,
-0.0034498498,
0.0025619485,
0.01794841,
0.00072459975,
-0.04479881,
-0.040360946,
-0.04605927,
-0.008514663,
0.02998842,
-0.024066888,
-0.013366117,
-0.0003666081,
0.0023732078,
-0.01165268,
-0.008166724,
-0.0031839719,
0.013372682,
0.0063679437,
0.013352987,
-0.008298022,
-0.01977345,
-0.035030253,
0.018145356,
-0.010904283,
-0.008803518,
-0.01163955,
-0.00924993,
0.011029016,
-0.030671168,
-0.01163955,
-0.023029635,
-0.012381383,
0.010530084,
-0.004231072,
-0.02035116,
-0.023817422,
0.014048865,
-0.012880315,
0.021349024,
-0.004887561,
0.0153093245,
-0.011219397,
0.012099093,
-0.036920942,
-0.0092368005,
0.022662,
-0.0033333232,
0.003915957,
0.0019940855,
0.001887406,
0.0015566996,
-0.008987335,
-0.00031552505,
0.02573437,
-0.040623542,
-0.010405351,
-0.06255028,
0.018959403,
0.00025992864,
-0.011127489,
-0.0056392406,
-0.009177716,
-0.0046807667,
-0.009919549,
0.01849986,
0.0050910725,
-0.012020314,
0.006699471,
-0.022071162,
0.012492986,
-0.02092887,
-0.024605209,
0.016530395,
0.0040078657,
0.01855238,
0.0074708452,
-0.0014606881,
-0.020443069,
0.014009476,
-0.010996192,
-0.004165423,
-0.009965504,
-0.03311331,
0.012407643,
-0.011554207,
0.0068471804,
0.007720311,
-0.02807147,
-0.010641688,
0.0120597035,
-0.00026854506,
-0.00644344,
-0.017423218,
0.045875452,
0.015099248,
0.01735757,
-0.0069784783,
-0.04718843,
0.0060955007,
0.010313443,
-0.010379092,
0.001175936,
-0.020810703,
-0.011015886,
-0.017200014,
-0.018421082,
0.026600936,
0.013497415,
-0.013510545,
-0.02702109,
-0.031353917,
-0.0072607687,
0.0033497354,
0.0034038955,
-0.024631469,
-0.016989937,
0.024894064,
0.013510545,
0.001416375,
-0.010845199,
0.013458026,
-0.0115673365,
-0.045218963,
-0.020666275,
0.015020469,
-0.049499273,
-0.018460471,
0.011659245,
0.003929087,
-0.005439012,
-0.0052289353,
-0.009020159,
-0.02268826,
-0.024460781,
0.007851609,
0.02702109,
0.02578689,
0.014180163,
-0.009197411,
-0.0021319482,
0.023029635,
-0.007733441,
0.01320856,
0.03056613,
-0.0022616046,
0.0035647354,
0.010136191,
0.030776206,
0.006390921,
0.013458026,
0.021900475,
0.0053471033,
0.0020909177,
-0.023712384,
-0.009105503,
0.0142064225,
-0.021493452,
-0.012538941,
0.018447341,
-0.010287183,
-0.010700772,
-0.0015501347,
-0.023108413,
-0.038680334,
-0.021756047,
0.00404069,
0.021795437,
0.014324591,
0.0059773326,
0.006325272,
0.0007479872,
0.013510545,
0.0059379432,
-0.018696807,
-0.0101558855,
0.0406498,
0.005350386,
0.034373768,
-0.015480012,
-0.012893445,
0.017213143,
-0.012703063,
0.036710866,
-0.024985973,
0.045035146,
-0.008370236,
0.008632831,
0.002085994,
-0.020114824,
-0.003863438,
-0.0018512991,
-0.012952529,
-0.0033595827,
0.009965504,
0.008035426,
0.08880984,
0.0024651163,
-0.010753291,
-0.011455733,
-0.008652525,
0.007831914,
-0.017554516,
-0.0011980925,
-0.023147803,
-0.01561131,
-0.010320008,
-0.007858174,
0.0063384017,
-0.01135726,
0.0058657294,
0.00778596,
-0.015860775,
0.0016674822,
0.011436039,
-0.025301088,
0.0011685505,
-0.005350386,
-0.0024208033,
0.022018643,
-0.011724894,
-0.006170997,
0.018473601,
-0.0052584773,
0.041595146,
-0.072056234,
-0.0013622148,
-0.0071622953,
-0.047529805,
-0.01978658,
-0.00023243815,
-0.018027188,
0.024933454,
-0.008147029,
0.028911777,
0.029778343,
0.006088936,
-0.0013310316,
-0.0024733224,
-0.043564614,
0.010352832,
0.0019776733,
0.007602143,
-0.010569474,
-0.010070542
] |
The EBNA1 protein of Epstein-Barr virus (EBV) binds to and activates DNA replication from the EBV latent origin of replication, oriP, via a direct interaction with the two noncontiguous subelements of oriP. The EBNA1 molecules bound to the oriP subelements interact efficiently with each other by a DNA looping mechanism. We have previously mapped a region of EBNA1 (termed the looping region) that is required to mediate the interaction of the EBNA1 molecules bound to the oriP subelements. We now demonstrate that two fragments of this region of EBNA1, which consist largely of | [
-0.033782534,
-0.017277278,
-0.020085834,
-0.03644467,
-0.033729292,
0.0046753804,
-0.011227568,
-0.0038967049,
-0.0051312717,
0.0038401345,
-0.020312116,
-0.0034308308,
-0.000945891,
0.003873411,
-0.013377245,
-0.010262543,
0.006312595,
-0.016877957,
-0.0040397947,
0.041050173,
-0.05100657,
0.0027070618,
-0.0012329028,
-0.043765552,
-0.011673477,
0.016265664,
-0.009490523,
-0.033968884,
-0.011799928,
-0.012052831,
0.005973173,
0.013137653,
-0.01637215,
0.010102815,
0.0046953466,
-0.017543491,
-0.00567701,
-0.002096434,
0.020179007,
0.005870015,
0.026741179,
0.014495343,
-0.024518294,
0.010601966,
0.0053475704,
0.0050979946,
0.0060663475,
0.009350761,
-0.006671984,
0.023852758,
0.0057535465,
-0.0025356866,
-0.014921285,
0.015041081,
-0.0052643786,
-0.018741453,
0.014202507,
-0.0003437902,
-0.002349337,
-0.025090653,
-0.022535,
-0.00413297,
-0.014947906,
0.00017927837,
-0.009743426,
0.03671089,
0.032451466,
0.008059624,
-0.00045381137,
0.000640993,
0.049994957,
0.021390282,
-0.025263691,
0.019939415,
0.016718227,
-0.03178593,
-0.030667832,
-0.024784507,
-0.011726719,
0.0064357193,
0.018022677,
-0.02369303,
0.0001087733,
0.005860032,
-0.0036571124,
-0.024185525,
0.0009924785,
0.010189334,
0.0096103195,
-0.000274533,
0.021683116,
0.030268513,
0.023945933,
-0.003123021,
-0.032211874,
0.02020563,
0.019127464,
0.024358565,
-0.007746822,
-0.023533301,
-0.01734383,
-0.014269061,
-0.013057788,
-0.011959656,
-0.01540047,
-0.004702002,
0.0028551433,
-0.035805758,
0.013922983,
0.008492221,
-0.018595036,
0.019300502,
-0.018368755,
-0.036843993,
0.015254052,
0.0027985729,
0.0285115,
-0.010269199,
-0.021403592,
-0.008978061,
0.0020049228,
0.036071975,
-0.010721762,
-0.030454861,
0.03713683,
0.0046520866,
-0.011334053,
-0.012691745,
-0.009690183,
-0.0023243795,
0.009177722,
0.038015336,
-0.00923762,
0.001921731,
-0.018035987,
-0.0017154154,
0.0016571811,
-0.028351773,
-0.00962363,
-0.010735072,
0.032211874,
0.021164,
-0.014295682,
-0.022774592,
0.015892966,
0.026807733,
-0.0010307466,
0.0058134445,
0.012398909,
0.00019071726,
-0.008645294,
-0.022535,
0.030374998,
-0.017476937,
-0.0069149043,
0.018768074,
-0.0034025453,
0.035566166,
-0.004901662,
-0.019979348,
-0.015054392,
-0.011021253,
0.0065056,
0.0033742602,
-0.0009625294,
0.04275394,
-0.013137653,
-0.014561896,
0.017170792,
-0.0369771,
0.0045489287,
0.007953138,
-0.07070639,
0.015387159,
-0.033649426,
0.015347227,
0.0104156155,
-0.0014059418,
-0.0053242766,
-0.020125765,
0.010628587,
0.0015789807,
0.021816224,
0.009863222,
-0.02407904,
-0.004788521,
0.0077734436,
-0.021337038,
0.0045223073,
-0.0025040738,
0.00024375203,
0.008425668,
0.012891404,
0.01252536,
-0.6312462,
-0.02636848,
0.012019554,
-0.01827558,
0.0015748212,
0.00827925,
0.012685088,
0.010888145,
0.0003722834,
0.018768074,
-0.031466473,
-0.0015590147,
0.021217242,
-0.01753018,
-0.018808007,
-0.03327673,
-0.005197825,
-0.009031304,
0.017184103,
0.0017070961,
-0.024212148,
-0.010515446,
0.0026504914,
0.022322029,
-0.018661588,
-0.011946346,
0.01405609,
-0.019473542,
0.006528894,
0.032238495,
-0.014854731,
0.022282097,
0.009843256,
0.00080904044,
0.029709462,
-0.009563732,
0.010162713,
0.010002985,
0.0106552085,
0.04858402,
0.0006938198,
-0.0061462116,
-0.0000630698,
0.0069415257,
-0.01812916,
0.012159317,
-0.0033110345,
0.020671504,
-0.014016158,
-0.0126984,
0.024358565,
0.010215956,
-0.033995505,
-0.001546536,
0.016438704,
0.01927388,
0.0073674675,
-0.0042860424,
0.01944692,
-0.006771814,
0.0075937496,
0.0021480129,
-0.0044690645,
-0.02330702,
-0.018328821,
-0.015347227,
-0.009297518,
0.046321206,
0.016066004,
0.010748384,
0.020511776,
0.020751368,
0.011460505,
0.0023143964,
-0.0009284207,
0.028138801,
-0.0077867545,
0.03407537,
-0.012505394,
0.014495343,
-0.014229129,
-0.0054274346,
-0.02869785,
-0.0013776566,
0.022042505,
-0.005870015,
-0.030747697,
0.04176895,
0.005989811,
-0.0124787735,
-0.0034840736,
0.01175334,
-0.005094667,
-0.025942538,
-0.031812552,
0.010814937,
-0.015679995,
0.0012911371,
0.008039658,
-0.021323727,
0.012245836,
-0.02984257,
0.00024791164,
-0.01560013,
0.01887456,
0.0030697782,
-0.024145594,
-0.0023260433,
0.066074274,
-0.01193969,
-0.0090712365,
0.0005095499,
0.0007570456,
0.008938129,
-0.00553392,
-0.026608072,
0.011766651,
0.00077950733,
0.0048550745,
-0.012585259,
0.0062294034,
-0.008319182,
-0.0013144307,
-0.0288842,
0.0060164323,
0.022774592,
0.007939828,
-0.014761557,
-0.00673521,
-0.024944235,
-0.0040031904,
0.007800065,
0.011147704,
-0.017237345,
0.032797545,
0.0155868195,
0.02021894,
0.022934321,
0.00047668914,
-0.032398224,
-0.024118973,
-0.011600267,
0.009091202,
-0.004352596,
-0.01262519,
-0.025436731,
-0.006182816,
-0.005786823,
-0.0030148716,
0.017796393,
0.03234498,
0.014189197,
-0.022881078,
0.01811585,
0.021443523,
-0.017796393,
-0.00829256,
-0.026142199,
-0.030321755,
-0.00520448,
-0.0074207103,
0.009397348,
-0.002064821,
-0.0005565533,
0.011953001,
-0.0045189797,
0.024212148,
-0.0022544984,
-0.013117686,
-0.046880256,
0.026900908,
0.0018102541,
-0.022787904,
-0.0025456697,
-0.011121082,
0.00520448,
-0.0068416954,
0.0038634283,
0.009364071,
0.0070945984,
-0.010468858,
-0.006082986,
-0.005966517,
-0.002277792,
0.031493094,
0.006395787,
0.014016158,
0.0048251254,
0.017437005,
0.022388583,
-0.009364071,
0.028724471,
-0.009696838,
0.024158904,
0.016957821,
-0.011560336,
0.0047619,
0.030934047,
-0.010768349,
0.03636481,
0.0013518671,
-0.014708314,
0.010369029,
-0.007347502,
0.022109058,
-0.016877957,
-0.0117599955,
-0.05579842,
0.019473542,
-0.014096022,
0.0008023851,
0.0000691012,
-0.0140028475,
0.006755176,
-0.011081151,
0.024571536,
-0.019939415,
0.029602977,
-0.0033576218,
-0.0051113055,
-0.039772347,
0.01908753,
0.025343556,
-0.011693442,
-0.009510489,
-0.005024786,
0.004272732,
0.026900908,
0.014215819,
0.0062294034,
-0.0045788777,
0.0039000325,
0.02443843,
0.0023326986,
-0.021416903,
-0.0070213894,
0.018515171,
-0.012086107,
0.021869466,
-0.009650251,
-0.009843256,
0.011161014,
-0.00036334028,
0.002044855,
0.032291736,
-0.004821798,
-0.009896499,
0.012798229,
-0.0024258734,
0.013443798,
-0.01847524,
0.006389132,
-0.03500712,
-0.003783564,
-0.004252766,
0.0067152437,
-0.0073275357,
0.029230278,
0.04211503,
0.013976226,
0.0063525275,
-0.018382065,
0.02811218,
-0.005420779,
0.012585259,
-0.029523114,
-0.0050979946,
-0.008485566,
-0.0045123245,
0.007886585,
-0.0048384364,
-0.007087943,
0.0075138854,
-0.014681692,
0.009503834,
0.011094461,
-0.018541792,
0.028484879,
0.0035472992,
0.008838299,
-0.025077343,
-0.02330702,
0.03175931,
-0.0038234962,
-0.0039932076,
-0.00630594,
-0.017916191,
-0.0063292338,
-0.0027120532,
0.010928078,
0.013949605,
0.016039383,
0.003540644,
0.016505256,
-0.011460505,
0.0013410521,
0.017876258,
-0.021723049,
0.016771471,
0.0016971132,
0.0002826442,
-0.014082711,
-0.02097765,
-0.00380353,
0.044644058,
0.0058334107,
0.031919036,
-0.0049648876,
0.004848419,
-0.01658512,
0.0073009143,
0.01039565,
-0.015293985,
-0.024558226,
0.002687096,
0.0018834628,
0.008385736,
0.0041862126,
0.0042061782,
0.010908112,
-0.029203657,
-0.03024189,
-0.010202645,
-0.00012811541,
0.018022677,
0.024052419,
-0.010941388,
0.024358565,
-0.010388995,
0.0071877735,
0.001098132,
-0.049515773,
0.02462478,
-0.011547024,
-0.00008100804,
0.003407537,
0.0012162644,
0.009104513,
0.018994356,
0.022481758,
0.0052011525,
-0.058673527,
0.0015207465,
-0.015653374,
-0.0055405754,
-0.001981629,
-0.0071079093,
0.022029195,
0.0040031904,
-0.006342544,
-0.0021713064,
0.021603253,
0.0049349386,
-0.024717953,
0.0050680456,
0.0058833254,
0.016598431,
0.02792583,
-0.004828453,
-0.041689087,
0.02350668,
0.021696426,
0.0015831403,
0.0098765325,
0.016425394,
0.004635448,
0.0015066039,
0.00486173,
0.020738058,
0.0067784693,
0.0045589115,
-0.012432186,
-0.013064443,
0.001414261,
0.019540096,
-0.0029882502,
-0.021017581,
-0.012798229,
-0.0042261444,
0.019659892,
-0.017743152,
-0.004821798,
0.007913206,
-0.01405609,
-0.025130585,
-0.013197551,
0.027246986,
-0.0073142247,
0.010641898,
-0.025117274,
-0.023906002,
-0.016718227,
-0.0029915778,
-0.005966517,
-0.003497384,
-0.023812827,
-0.029895812,
0.0060264156,
0.01927388,
0.020951029,
0.011021253,
0.0061195903,
-0.014668382,
0.0007412391,
-0.009004682,
-0.009384037,
0.009929775,
-0.030268513,
-0.008079589,
0.022481758,
0.00856543,
-0.0018634967,
-0.013170929,
-0.016425394,
-0.0021779619,
0.011480471,
0.030082162,
-0.012445496,
0.0024574865,
0.055319235,
0.02332033,
0.031892415,
0.000021278907,
-0.0023077412,
-0.009390693,
-0.033196863,
0.0025406783,
-0.0045822053,
0.0070413556,
-0.020445222,
-0.01658512,
0.008072934,
-0.026408412,
-0.013536973,
0.0077734436,
-0.00693487,
-0.0053242766,
-0.0014816463,
0.0016180809,
0.031812552,
-0.008372425,
0.0121193845,
-0.014229129,
-0.004881696,
-0.0064856345,
-0.022122368,
0.023133982,
-0.0083524585,
-0.009577042,
0.008199386,
0.010448893,
-0.0025406783,
0.011467161,
-0.002329371,
-0.010275854,
0.009716805,
0.0105354125,
-0.0012986243,
-0.027606374,
0.004495686,
0.010229266,
0.02177629,
-0.0058733425,
-0.016092626,
0.012858128,
0.0031596255,
0.025356866,
-0.0016646683,
0.00913779,
-0.025130585,
0.009024649,
0.0489301,
-0.022122368,
-0.015320606,
0.004049778,
-0.0016746514,
-0.0042893705,
-0.0037136828,
-0.009184377,
-0.01271171,
-0.0064423745,
-0.00923762,
0.04584202,
0.0060264156,
0.039000325,
-0.0063225785,
-0.00659212,
0.022082437,
0.013403866,
0.0077734436,
-0.010049572,
-0.008971406,
-0.005899964,
-0.0039000325,
0.003600542,
0.002126383,
0.019553406,
-0.03151972,
0.025316935,
0.012931337,
-0.004811815,
-0.010076193,
0.0075005745,
-0.011633544,
0.00082609477,
0.017050996,
-0.017303899,
0.02021894,
-0.0362317,
0.0027420025,
0.004628793,
-0.018555103,
0.01984624,
-0.012931337,
0.013909672,
-0.008039658,
0.019167395,
-0.016318908,
0.01040896,
-0.008898197,
0.010801626,
-0.011873136,
0.000925925,
0.0250241,
0.004914973,
0.008525498,
-0.0001708552,
-0.015413781,
0.009390693,
0.01039565,
0.009417314,
-0.015120945,
-0.015533577,
0.009144445,
0.0034308308,
-0.017996054,
-0.032025523,
-0.03540644,
0.002715381,
0.012292423,
0.012099419,
0.026261995,
-0.005320949,
-0.016851336,
0.038734112,
0.0013468756,
0.0334897,
-0.021523388,
0.038734112,
0.0050281137,
0.022787904,
-0.022814525,
-0.0076137153,
-0.027246986,
0.0072410163,
0.019792998,
0.021723049,
0.0036970444,
-0.015533577,
-0.005623767,
-0.017370451,
0.0021629874,
-0.025822742,
0.032850787,
-0.035140224,
0.0029949055,
0.0014791506,
-0.005706959,
0.003873411,
0.01734383,
-0.011493782,
0.034953874,
-0.005227774,
-0.00250241,
-0.025702944,
0.017982744,
-0.005816772,
0.022175612,
-0.016185801,
-0.010814937,
-0.0052643786,
-0.018808007,
0.0060363985,
-0.021390282,
-0.00072376884,
0.028591365,
-0.0054374174,
-0.0052976552,
-0.006132901,
0.010974665,
-0.006295957,
-0.0033958901,
0.013117686,
0.039346404,
0.0117599955,
-0.022029195,
0.0047619,
0.03317024,
0.023054117,
0.013736634,
-0.011161014,
-0.018009365,
-0.02156332,
0.0019034288,
0.025702944,
0.0030398292,
0.0002909634,
0.003540644,
-0.013883051,
-0.002277792,
-0.028617986,
-0.026608072,
0.014734935,
-0.06458347,
-0.022002572,
-0.007926516,
0.03309038,
0.02619544,
0.018967735,
0.023360264,
0.005271034,
0.032052144,
-0.020338736,
0.00033505505,
0.0026222062,
0.005560541,
-0.010428927,
0.0048084874,
-0.004212834,
-0.0092509305,
0.015533577,
0.008485566,
-0.0014616803,
-0.016452014,
-0.015560199,
0.025676323,
0.012485429,
-0.038973704,
0.026927529,
-0.020325426,
0.016638365,
-0.013044477,
-0.013430487,
0.009324139,
-0.002808556,
-0.0038534452,
0.00049166364,
-0.00654886,
-0.0069149043,
-0.0059099467,
-0.013150963,
0.003843462,
-0.01653188,
-0.021696426,
-0.018009365,
0.00020153218,
-0.0060730027,
-0.0050613903,
0.010149403,
0.001088149,
-0.008472255,
-0.00418954,
-0.0066986056,
0.008019691,
-0.019313812,
0.02061826,
-0.001424244,
0.025183829,
-0.007826687,
0.0018934458,
0.008445634,
-0.03639143,
-0.019540096,
0.0049382662,
-0.004751917,
0.019699823,
-0.0040431223,
0.00481847,
-0.024039108,
-0.025450042,
-0.047678895,
0.011260845,
-0.006385804,
0.020378668,
-0.001332733,
0.02273466,
0.0073874337,
0.0066653285,
-0.007400744,
0.020179007,
-0.0048650578,
-0.008186075,
0.014508653,
-0.014721625,
0.020125765,
0.01521412,
-0.024678022,
-0.0044025113,
0.014708314,
0.003813513,
-0.0013377245,
0.021203931,
-0.024012487,
0.011114427,
0.0004812647,
-0.002440848,
0.007999726,
0.031812552,
0.007161152,
-0.02734016,
-0.008305871,
0.011141049,
0.020951029,
-0.035752516,
-0.0024957545,
-0.0028801009,
0.03599211,
0.019406987,
-0.005796806,
-0.017809706,
0.015813101,
-0.023759585,
0.040704094,
0.01770322,
0.012705055,
0.028351773,
0.003061459,
-0.013789876,
-0.021363659,
-0.017463626,
-0.04333961,
-0.022242164,
0.025143895,
-0.0075604725,
-0.02273466,
-0.0051911697,
-0.019739754,
-0.030374998,
-0.0040031904,
0.013696701,
-0.020352047,
-0.034953874,
0.00819273,
0.020591639,
-0.015653374,
-0.003773581,
-0.0020831232,
-0.009903154,
-0.013264104,
0.005460711,
-0.008465599,
-0.01086818,
-0.0053409147,
-0.014455411,
-0.013949605,
-0.014135954,
-0.001199626,
-0.0025856018,
-0.0035339885,
0.0040830546,
0.18507186,
-0.015187499,
-0.0075538172,
0.011513748,
-0.0267678,
-0.016518569,
0.008731813,
0.009324139,
0.005397485,
-0.016199112,
0.003670423,
0.017809706,
-0.007933172,
0.0013851438,
0.03138661,
-0.011487126,
-0.01985955,
-0.004479048,
-0.013031167,
0.0030564675,
0.010382339,
-0.018847939,
-0.005653716,
-0.0042893705,
0.02734016,
-0.008039658,
-0.044830408,
0.018847939,
-0.0053109657,
0.010954699,
-0.015120945,
0.010721762,
-0.0023759585,
0.009863222,
-0.007926516,
0.00390336,
0.00046421034,
-0.015440402,
-0.014042779,
0.015733236,
0.0029849226,
0.016305597,
-0.018981045,
-0.022202233,
-0.02081792,
0.008232662,
0.0016738194,
-0.032265116,
-0.0014467058,
0.009916465,
-0.021283796,
-0.006755176,
-0.0058500487,
0.011234224,
0.0028102198,
-0.009324139,
0.020272182,
0.021257173,
-0.0029915778,
0.029975677,
-0.0017004408,
0.019540096,
-0.041875433,
0.0075937496,
-0.002808556,
0.020139076,
-0.008938129,
0.012738331,
0.026155509,
-0.04408501,
0.010575344,
-0.0068283845,
-0.013710012,
0.011593612,
-0.02117731,
-0.013370589,
0.0415826,
0.022388583,
0.019966036,
0.008392391,
0.029895812,
0.010934733,
-0.029363384,
0.01638546,
-0.0034507967,
-0.024012487,
0.023546614,
0.002775279,
-0.02525038,
-0.016079316,
0.02270804,
-0.01425575,
-0.0071744625,
0.0028667902,
0.013909672,
-0.009976363,
-0.035299953,
0.0028251943,
-0.01733052,
0.0030997272,
-0.018754764,
0.08183413,
0.020312116,
0.00069922727,
-0.014655071,
-0.003873411,
0.013111031,
0.0059465514,
0.019194016,
-0.010668519,
0.024331944,
-0.0038833942,
0.014295682,
-0.0066253967,
-0.0048883515,
0.0023676392,
-0.00789324,
-0.0384679,
0.012591914,
0.012918026,
-0.007533851,
-0.033782534,
-0.002938335,
0.01846193,
-0.02269473,
0.020844543,
-0.017929502,
0.008405701,
-0.00042677403,
-0.020684814,
-0.0065255663,
0.0038068576,
0.0038567728,
0.0064357193,
0.016452014,
-0.0035572823,
0.011487126,
-0.024531605,
-0.011027908,
0.011307432,
-0.007374123,
-0.016891267,
0.02407904,
0.0073807784,
-0.02100427,
-0.022574933,
0.03080094,
0.008425668,
-0.004279387,
-0.0110744955,
-0.016159179,
-0.029709462,
0.012165972,
0.00962363,
0.008631983,
-0.034394827,
-0.019686513,
-0.035832383,
0.008492221,
-0.0014883017,
-0.03865425,
0.009856567,
0.006023088,
-0.03482077,
-0.009903154,
0.007760133,
-0.16718228,
-0.005271034,
0.00626268,
-0.014016158,
0.051139675,
0.014189197,
0.007048011,
-0.0013410521,
-0.009517144,
0.008039658,
0.024970857,
0.0186749,
-0.04850416,
-0.044377845,
-0.01289806,
-0.012146005,
0.0027237001,
0.00060397264,
0.032504708,
-0.012585259,
0.029150413,
-0.034368206,
0.035672653,
-0.011926379,
0.005870015,
0.011799928,
-0.008592051,
-0.010914767,
-0.011467161,
-0.0053043105,
0.003101391,
0.00031072146,
0.02867123,
-0.031093774,
0.03351632,
-0.020937717,
0.004848419,
0.00086436304,
0.014561896,
0.026488276,
0.015267363,
0.017290588,
-0.0121193845,
0.0026222062,
0.0010939725,
0.039532755,
0.02100427,
-0.014615139,
0.028218666,
-0.00096585706,
0.006196127,
-0.017783083,
0.022069126,
0.009756736,
0.014934596,
-0.014974528,
0.013363934,
0.024864372,
-0.0044690645,
0.009417314,
-0.0050014923,
0.009949742,
0.051751968,
-0.018701522,
-0.0007882425,
-0.035592787,
-0.01828889,
0.025343556,
-0.032691058,
0.016971132,
-0.007886585,
0.003212868,
0.019792998,
-0.02158994,
0.011859826,
0.019792998,
-0.0088316435,
0.016904578,
0.0030381654,
-0.004895007,
-0.01749025,
0.023945933,
-0.007866618,
-0.012412219,
-0.016931199,
-0.014175886,
-0.021470144,
0.019167395,
0.016292287,
-0.011779962,
0.012032865,
-0.034208477,
0.029496493,
-0.008445634,
0.026608072,
0.019340435,
0.026900908,
0.0009234292,
-0.011686787,
0.01174003,
0.011207602,
-0.021683116,
-0.004422477,
0.023732962,
0.05060725,
0.0077135456,
0.0136434585,
-0.0012453815,
0.053189524,
-0.021510078,
-0.012871439,
-0.016664986,
0.022202233,
0.043792173,
-0.0049282834,
0.025450042,
-0.01731721,
0.006152867,
-0.0046121543,
-0.0061395564,
0.07113233,
0.0015540232,
-0.02096434,
0.0132241715,
-0.022322029,
-0.028538123,
-0.12543996,
-0.011087806,
0.0077068903,
0.0023942606,
-0.010908112,
0.011047874,
0.016092626,
0.02158994,
-0.012811541,
0.0053043105,
-0.039186675,
-0.0130178565,
0.00799307,
-0.021656495,
0.0032993876,
-0.0023776223,
-0.00019539679,
-0.0065521877,
-0.021217242,
0.026421722,
0.010042917,
0.0052843443,
-0.018222336,
-0.0056304224,
0.017463626,
-0.008651949,
-0.033356592,
0.019792998,
0.00644903,
0.0012686753,
-0.001667164,
-0.02117731,
0.012951302,
0.0042893705,
-0.028937442,
0.008046313,
-0.026927529,
-0.01128081,
0.02426539,
-0.023426816,
0.0013959587,
-0.0034341584,
0.011600267,
0.0066353795,
0.0030181992,
-0.024491671,
0.004598844,
0.003783564,
0.0012096091,
0.012192593,
-0.016997753,
-0.0019649907,
-0.04347272,
-0.011919724,
0.0065654987,
-0.016145868,
-0.0024874355,
0.009177722,
-0.00054865004,
-0.00693487,
-0.014774867,
-0.010894801,
-0.011393952,
-0.006319251,
0.021483455,
0.0025922572,
0.005187842,
-0.011593612,
0.013803187,
-0.008252628,
0.0026937511,
-0.008738468,
-0.010542068,
0.017942812,
-0.015493644,
-0.007866618,
-0.010349062,
-0.011686787,
0.004791849,
-0.001057368,
-0.01212604,
-0.019979348,
0.00500482,
-0.022481758,
0.03849452,
-0.0023110688,
-0.0070413556,
0.01088149,
0.017024374,
-0.007926516,
-0.014175886,
0.052976552,
0.0033409835,
-0.044590816,
-0.0130777545,
0.013137653,
-0.011094461,
-0.012205904,
0.010688485,
0.0036670954,
-0.029762706,
-0.0029832586,
-0.059738383,
0.019154085,
0.007214395,
0.00044881986,
0.015733236,
-0.0028218667,
0.016957821,
-0.0074606426,
-0.0005615448,
0.02869785,
-0.02256162,
0.02483775,
-0.01923395,
0.002156332,
-0.020325426,
-0.022947632,
0.030774318,
-0.00022129025,
0.0013019519,
0.0023476733,
0.00829256,
0.006395787,
0.0062393867,
0.012871439,
0.004066416,
-0.0077867545,
-0.020924406,
0.016012762,
-0.009597008,
-0.0058200997,
-0.008878231,
-0.053801816,
-0.008924819,
0.008172764,
0.006588792,
-0.015506956,
-0.0019699824,
0.02272135,
0.023346953,
0.030215269,
-0.02771286,
-0.039213296,
0.012798229,
0.008738468,
0.013463764,
-0.001465008,
-0.04664066,
0.008066279,
0.0044624093,
-0.020152386,
0.031466473,
0.016931199,
-0.023613166,
-0.02252169,
0.0010215956,
0.0022611537,
0.0025140569,
-0.018515171,
0.0056437333,
-0.011813238,
0.029549735,
0.0066486904,
-0.0016754833,
-0.000569448,
-0.02096434,
-0.0011255853,
-0.019739754,
-0.025636392,
-0.0030181992,
-0.013104375,
-0.013177584,
0.02270804,
-0.002277792,
0.020418601,
0.010582,
0.0009733443,
-0.019340435,
-0.0059532067,
-0.0026704574,
-0.009217653,
-0.0029216968,
-0.01808923,
0.008911508,
0.008339148,
0.04557581,
0.0036471295,
-0.003123021,
0.014655071,
-0.01262519,
-0.007686924,
0.0013160947,
0.0046620695,
0.019327125,
0.035885625,
0.020431912,
0.012339011,
-0.005500643,
0.01009616,
0.005766857,
-0.004352596,
0.0122990785,
0.0020831232,
0.02023225,
-0.026275305,
-0.007973104,
0.037216693,
-0.028617986,
-0.04347272,
-0.008658605,
-0.016784782,
0.010069538,
-0.0058300826,
-0.00394662,
0.011586957,
-0.0048584025,
-0.0014350589,
-0.008778401,
-0.003873411,
0.0014392185,
0.017024374,
0.020498464,
0.02061826,
-0.024797818,
-0.019526783,
0.014774867,
0.006039726,
0.008811678,
-0.0026338531,
0.02330702,
-0.01579979,
0.024531605,
-0.01262519,
-0.010668519,
-0.019659892,
-0.018448617,
0.0077934097,
0.007973104,
0.022974253,
-0.009803324,
0.08982054,
0.034128614,
-0.018408686,
0.0030065523,
-0.03367605,
0.013071099,
0.013736634,
-0.0068217292,
-0.029549735,
-0.040890444,
0.01908753,
-0.023586545,
0.005899964,
-0.031998903,
-0.02019232,
0.04006518,
0.007214395,
0.029336764,
-0.015347227,
-0.022841146,
0.008638639,
-0.01923395,
0.010488825,
0.014575207,
-0.021829534,
0.022148991,
0.00567701,
-0.0054573836,
-0.0062194206,
-0.04331299,
0.020884475,
-0.021137377,
-0.04509662,
0.0038301514,
0.017783083,
-0.008685226,
-0.013989536,
-0.0063691656,
0.031439852,
0.0380952,
0.009364071,
0.011427228,
0.009696838,
-0.0148148,
0.025623081,
0.009197688,
-0.015187499,
-0.0011156023,
-0.011779962
] |
The National High Blood Pressure Education Program Coordinating Committee published its first statement on the primary prevention of hypertension in 1993. This article updates the 1993 report, using new and further evidence from the scientific literature. Current recommendations for primary prevention of hypertension involve a population-based approach and an intensive targeted strategy focused on individuals at high risk for hypertension. These 2 strategies are complementary and emphasize 6 approaches with proven efficacy for prevention of hypertension: engage in moderate physical activity; maintain normal body weight; limit alcohol consumption; reduce sodium intake; maintain adequate intake of potassium; and consume a diet rich in fruits, vegetables, and low-fat | [
-0.002065736,
0.006079801,
0.013631954,
-0.039118886,
0.00013218251,
0.022592997,
-0.00021934563,
0.008834115,
-0.02279608,
-0.0148377605,
-0.025220385,
0.0042806114,
-0.005924315,
0.016437039,
-0.02420497,
-0.0053563174,
0.062143434,
-0.031097103,
0.025461545,
0.0014263416,
-0.019940224,
0.0011931133,
0.009430672,
-0.014710833,
-0.029751677,
0.007736197,
0.028330095,
-0.020739863,
0.007526768,
-0.03160481,
0.012514997,
0.013340022,
0.008345447,
-0.00708887,
-0.0053436244,
0.012216719,
-0.014215818,
0.0057307514,
0.019178662,
-0.019356359,
-0.00035361055,
-0.002606762,
-0.005422954,
-0.009386248,
0.005337278,
0.004150511,
0.015243926,
-0.0013248,
-0.016640123,
0.035387233,
0.032670997,
0.008059861,
-0.00028042923,
0.01012877,
-0.014330052,
-0.012470572,
-0.027238524,
0.05280161,
0.0068223234,
-0.028837802,
-0.005426127,
-0.010693595,
-0.025182307,
0.007450612,
-0.025486931,
-0.0075331144,
-0.0048010116,
0.010680903,
0.007000021,
0.010839561,
0.013695418,
0.032239445,
-0.014520443,
0.006670011,
0.01662743,
-0.015713556,
-0.004842263,
-0.0134161785,
0.014761604,
-0.0076283095,
0.012115177,
0.008256597,
-0.004582063,
0.0026940245,
0.0015516819,
0.0050485195,
0.0018991445,
-0.011080722,
0.0062194206,
-0.029523209,
-0.00038692888,
0.00008002347,
-0.0014747324,
0.010922064,
-0.027797,
0.022034518,
0.016614737,
0.01676705,
-0.013086168,
-0.012000943,
0.0035253959,
-0.019534057,
-0.028558563,
-0.0023227632,
-0.031249415,
0.013581184,
-0.020930253,
0.0005933835,
0.009678179,
-0.022262987,
-0.017604768,
0.04178435,
-0.011867669,
-0.027390836,
0.008421603,
-0.00908797,
-0.0036808813,
-0.018137861,
-0.005486417,
0.0028146051,
0.0013620848,
0.012413455,
0.012375377,
0.020790635,
0.011715357,
-0.0043059965,
-0.037519604,
-0.028837802,
0.0036237643,
-0.0016008661,
-0.019495979,
0.024408052,
0.0041854163,
0.014152355,
-0.04219052,
0.006815977,
0.0046899505,
-0.019800603,
-0.021691816,
-0.03061478,
0.00595922,
0.025639243,
-0.025690014,
-0.022504147,
0.001078879,
0.04130203,
0.029980145,
0.03739268,
-0.009417979,
0.00081629894,
-0.0021514117,
-0.007431573,
0.014571213,
-0.00094957225,
-0.031985592,
-0.0032651958,
-0.02576617,
0.012768851,
-0.008231212,
0.004061662,
0.01954675,
-0.02204721,
0.016703587,
0.025042687,
-0.0041663772,
0.017833237,
0.010534937,
-0.014863146,
0.0015786539,
0.0012010463,
0.008345447,
0.033787955,
-0.027923929,
-0.0018198151,
0.007615617,
0.009411633,
0.022694537,
-0.0020720824,
0.001159795,
-0.02807624,
-0.008783345,
-0.0006580369,
0.018709032,
0.040210456,
-0.021272955,
0.016272034,
0.04432289,
-0.0068984795,
0.015815098,
-0.03848425,
0.0056133443,
0.020765249,
-0.020092536,
-0.032620225,
-0.6494598,
-0.033381786,
-0.0035000106,
-0.025245769,
0.014660062,
0.018544028,
0.027974699,
0.010833215,
0.002065736,
0.027517762,
0.01785862,
-0.0065303915,
-0.00899912,
-0.014380823,
-0.005940181,
-0.007844085,
-0.0026781587,
-0.016525889,
0.0041282987,
-0.030462468,
-0.013923886,
0.008523145,
-0.020524086,
-0.005039,
0.020854097,
0.022440685,
-0.0065684696,
-0.009621062,
-0.011182264,
0.03523492,
0.0019499152,
0.010350892,
0.021031795,
0.02769546,
0.04008353,
-0.023735339,
-0.014710833,
0.00047161293,
-0.0020942946,
0.015053536,
-0.024230354,
-0.011556699,
0.028330095,
0.005537188,
0.0055340147,
0.016944747,
0.030107072,
-0.013809652,
0.00563873,
-0.0012073925,
0.009259321,
-0.00016639329,
-0.009379901,
-0.004258399,
0.0037665572,
-0.0053975685,
0.004385326,
0.006044896,
-0.020054458,
0.0056482493,
-0.009652794,
0.015269312,
-0.0054959366,
0.016462425,
-0.0090498915,
0.022808772,
-0.010731674,
0.010262043,
-0.008002744,
0.006790592,
-0.012407109,
0.02199644,
-0.0068604015,
-0.026705429,
0.038306553,
-0.013428871,
0.013581184,
0.0044868677,
-0.014495057,
-0.009392594,
-0.0009535387,
0.021552196,
-0.0077806218,
0.012292875,
0.01530739,
0.0090435445,
-0.017934777,
-0.004966017,
0.008586608,
-0.020308312,
0.018518642,
-0.018683646,
0.013555798,
-0.021057181,
-0.001351772,
0.016475117,
-0.0015461289,
0.00814871,
0.018429793,
0.011632855,
-0.020435238,
-0.0033857764,
-0.015155078,
0.0014453806,
0.01104899,
0.01184863,
-0.033508714,
0.029523209,
0.03947428,
-0.007177719,
0.016043566,
-0.0148123745,
-0.04089586,
-0.0049374583,
0.012959241,
-0.024814218,
0.0007056345,
-0.020295618,
0.008980081,
0.001973714,
0.012495958,
-0.0017769772,
0.00873892,
-0.017414378,
0.010204926,
0.0017039942,
0.011391694,
0.008472374,
-0.009621062,
-0.039347354,
0.002289445,
0.0024798352,
0.009614716,
0.020765249,
0.025563087,
-0.012089792,
0.0019054908,
0.011391694,
-0.008726228,
-0.0028257112,
-0.00675886,
-0.016183186,
0.0021641045,
0.0030208614,
0.0016881283,
-0.035438005,
-0.0007262601,
-0.006270191,
0.0031097103,
-0.0016532235,
-0.003417508,
-0.014964687,
-0.01099822,
0.033153318,
0.00291456,
-0.016970133,
0.004080701,
-0.02609618,
-0.010287429,
-0.023684569,
0.03170635,
-0.0028701355,
-0.033178706,
0.017845929,
0.01403812,
-0.029117042,
0.00053785293,
0.02496653,
-0.018683646,
-0.029218582,
0.013289251,
-0.008523145,
-0.008815076,
0.023913037,
-0.018150553,
0.014609291,
-0.004458309,
-0.0033476981,
0.010661864,
0.0104778195,
-0.0059655667,
-0.04130203,
-0.02331648,
0.0019388091,
0.024319204,
-0.011823245,
0.019191355,
-0.014482365,
0.015675478,
0.010649171,
-0.005733925,
0.008643725,
-0.016272034,
-0.005315066,
0.004582063,
-0.0038522328,
-0.008459681,
-0.015447009,
0.011766128,
0.027086211,
0.049729977,
-0.0014168221,
0.0026416671,
0.0014675928,
0.0034968373,
-0.02279608,
0.023189554,
-0.01794747,
0.0054927636,
-0.0065875086,
0.0068413625,
0.0006695397,
-0.022618381,
-0.027847772,
0.00165481,
0.007869471,
-0.0030287942,
-0.0038649256,
-0.032340985,
0.0063780793,
0.017465148,
0.0007928968,
0.013035397,
-0.0035476082,
-0.032391757,
0.036707275,
0.030310156,
0.027797,
-0.0054007415,
-0.0063780793,
-0.018328251,
-0.0045122528,
0.010084346,
0.011087068,
-0.014545828,
0.013454257,
-0.0008170922,
-0.034016423,
-0.0005180206,
0.040946633,
0.008446989,
-0.009576638,
-0.0037284791,
-0.0045059067,
0.013949271,
0.0033445251,
0.027441606,
0.011702664,
-0.013695418,
0.02237722,
-0.0009226003,
0.007469651,
-0.0083264075,
-0.0133527145,
-0.010211273,
-0.0031430286,
0.0026987842,
0.020562164,
0.028507791,
0.034422588,
0.026299264,
0.0058989297,
0.007641002,
-0.01785862,
-0.001438241,
-0.023811495,
0.021755278,
-0.021082565,
-0.0083391005,
0.0017103406,
-0.04051508,
-0.01200729,
0.0025972426,
-0.046429876,
0.013593876,
0.02053678,
-0.0074379193,
0.009456057,
0.01874711,
0.0033445251,
-0.033762567,
0.0051088096,
0.0155612435,
0.040159687,
-0.0034428935,
-0.03391488,
0.0005025514,
-0.012369031,
0.00086230994,
0.0126863485,
0.010395317,
-0.02100641,
-0.013301944,
-0.01264827,
-0.011886708,
-0.017731695,
0.027010053,
0.019851375,
0.016246649,
-0.006305096,
0.0019673677,
-0.007564846,
-0.029142426,
-0.032366373,
0.050339226,
0.015789712,
0.022402607,
-0.0010757059,
0.014139662,
-0.005426127,
0.017515918,
-0.0010241418,
0.030970175,
-0.0027479683,
0.01836633,
-0.0065176985,
-0.015523165,
0.006638279,
0.018683646,
-0.031097103,
-0.013200402,
-0.03343256,
-0.010408009,
-0.004315516,
0.0703683,
-0.010230312,
0.013073475,
0.014723525,
0.004293304,
0.011302845,
-0.0042076283,
-0.03137634,
0.015612015,
0.012184987,
0.011283806,
0.03282331,
0.0028146051,
0.0029113868,
0.004293304,
0.00934817,
-0.009532214,
-0.034701828,
0.0032350505,
0.0040838746,
-0.00013674395,
0.014469672,
0.031630196,
0.037088055,
0.03508261,
-0.012902124,
0.013543106,
0.022199523,
0.024522286,
0.0071142553,
-0.0069746356,
0.012705388,
0.0033001006,
0.01066821,
-0.017249372,
0.031020945,
-0.013835037,
0.003144615,
0.009487789,
-0.012845007,
0.025499623,
0.010744366,
0.011175917,
0.009652794,
-0.016792435,
-0.012369031,
0.0070254067,
0.007717158,
0.006470101,
-0.005257949,
-0.011563045,
0.015853176,
-0.012933856,
-0.020955639,
0.015954718,
0.00004796946,
-0.0064383694,
-0.008408911,
-0.009011813,
-0.014558521,
-0.02147604,
-0.019229433,
0.030919405,
-0.026603889,
-0.0042457064,
0.009970112,
-0.012565767,
0.011797859,
0.0042108013,
0.0290155,
-0.009919341,
0.005039,
-0.025651935,
0.021222185,
0.014406209,
0.0074569583,
0.01591664,
0.007380802,
0.012470572,
0.012908471,
-0.016830513,
-0.010300122,
-0.006873094,
-0.024039963,
0.018087089,
0.007799661,
-0.013796959,
-0.0035285691,
-0.012273836,
0.008631032,
-0.008834115,
-0.028457021,
0.03716421,
-0.011461503,
-0.0047978386,
-0.0016579833,
0.017541304,
-0.010915717,
-0.010376278,
-0.016246649,
-0.024408052,
-0.0066953963,
-0.00004313533,
-0.024953838,
0.0077869683,
-0.008872193,
-0.003306447,
-0.00063106493,
-0.0003329849,
-0.018391715,
0.040845092,
-0.025194999,
0.002200596,
0.0053785294,
0.02133642,
0.012064407,
0.012204026,
-0.002073669,
0.014012735,
0.0028320574,
-0.011505928,
0.015269312,
0.028736262,
-0.0016659162,
-0.035793398,
0.005740271,
0.008021783,
-0.017833237,
-0.03663112,
0.00675886,
0.000121968864,
0.046836045,
0.0045725433,
-0.031858664,
-0.053918567,
0.022123367,
-0.00021121437,
-0.0036586693,
-0.013441564,
-0.025334619,
0.0033635641,
-0.023214938,
-0.009646448,
-0.009430672,
0.02807624,
-0.025182307,
0.0061845155,
-0.02736545,
-0.016386269,
-0.0019467421,
0.0097606825,
-0.011271113,
-0.032899465,
0.008072554,
0.0037697302,
-0.0062448056,
-0.0038649256,
-0.009417979,
0.0063304813,
0.024039963,
-0.014050813,
-0.00023501317,
-0.017262064,
0.010680903,
0.012153255,
-0.0006378079,
-0.006739821,
0.007932934,
-0.033940267,
0.029040886,
0.018455178,
0.0090181595,
0.010223965,
0.010947449,
0.023392636,
-0.011099761,
0.012432494,
-0.021222185,
-0.010649171,
-0.036681887,
0.016728971,
-0.011315538,
-0.011074376,
0.032899465,
-0.032670997,
-0.017655538,
0.01888673,
0.006796938,
0.0036681888,
-0.0017214468,
-0.008656418,
-0.016703587,
-0.004915246,
-0.0052040047,
0.0104778195,
-0.011169571,
-0.0057053664,
-0.02995476,
0.01836633,
0.0097797215,
0.011683625,
-0.0049374583,
-0.0065113525,
-0.01907712,
-0.024331896,
0.010877639,
-0.044957526,
0.009335477,
-0.009367209,
0.0029050405,
0.0035000106,
0.018391715,
-0.0001868206,
0.007107909,
0.004848609,
0.015091614,
0.006213074,
0.027670074,
-0.016589353,
-0.0016159387,
-0.001397783,
-0.024611134,
0.019013656,
-0.015485087,
0.028406251,
0.015713556,
-0.000981304,
-0.00457889,
0.020765249,
0.0016246649,
0.016284727,
0.02515692,
-0.005039,
-0.008129671,
-0.028533177,
-0.018379021,
0.04574447,
-0.015193156,
-0.039626595,
0.047216825,
0.010617439,
-0.012762505,
0.0058957567,
-0.0019768872,
-0.009900302,
0.0077615827,
0.023963807,
-0.008440642,
0.01836633,
-0.016259342,
-0.029878603,
0.023963807,
-0.00927836,
0.011296499,
0.0054197805,
-0.023938423,
0.005353144,
-0.0018896249,
0.015180463,
0.0045027332,
0.0012335712,
0.012819622,
-0.010744366,
-0.0074823434,
0.0156374,
-0.0006243219,
0.025613857,
0.016551275,
0.00048509892,
0.034524128,
-0.0045725433,
-0.043739025,
0.02731468,
-0.016183186,
-0.0070254067,
0.0036301108,
-0.027441606,
-0.032467913,
-0.014418901,
0.0057656565,
0.020651015,
0.008110632,
-0.038687333,
0.0010622198,
-0.008523145,
-0.019864067,
-0.0045344653,
-0.0054768976,
-0.022275679,
-0.014495057,
-0.024141505,
-0.013949271,
-0.024039963,
0.0133654075,
0.007990051,
-0.006942904,
0.0037126131,
0.011518621,
-0.015383546,
0.0104905125,
-0.003801462,
0.016741665,
-0.01747784,
0.020409852,
-0.043916725,
-0.0078060073,
0.0048676482,
0.0040331036,
-0.015548551,
-0.0056323833,
0.019673677,
0.011175917,
-0.006581162,
0.00070444454,
0.019229433,
-0.006140091,
0.0035952057,
-0.013225788,
-0.026756201,
0.016513195,
-0.009107009,
-0.009716257,
0.032137904,
-0.003022448,
0.026705429,
-0.018518642,
0.013720803,
0.007945627,
-0.007634656,
-0.02510615,
-0.04366287,
0.03843348,
-0.022136059,
0.000016287306,
0.0054546855,
0.027238524,
-0.009379901,
0.003474625,
-0.0104651265,
-0.0026416671,
-0.011455157,
0.031757124,
0.011182264,
-0.018531334,
-0.02364649,
-0.0077869683,
-0.008821423,
-0.015751634,
-0.017693616,
0.012914817,
0.0030636992,
0.033559486,
0.034041807,
-0.003068459,
0.014368131,
-0.00795832,
-0.046785273,
-0.018518642,
0.013733496,
0.01973714,
-0.009855878,
0.005990952,
0.026172336,
0.02741622,
0.009316438,
0.0034016422,
-0.018328251,
-0.0022053558,
0.01019858,
-0.0012827554,
0.01351772,
0.01403812,
-0.023240324,
-0.008624686,
0.010122424,
-0.01728745,
-0.005311893,
0.0168559,
0.020308312,
0.01973714,
0.013860422,
0.010845908,
0.009722604,
-0.04092125,
0.005787869,
-0.024420744,
0.018353637,
0.01066821,
0.0033381786,
-0.017706309,
-0.0155866295,
0.0062828837,
0.008573915,
-0.008193134,
-0.037291136,
-0.028177783,
0.011861323,
-0.017972855,
-0.008865847,
0.0069682896,
-0.019254819,
0.0052230437,
0.0040108915,
0.012242104,
0.0058418126,
-0.0014771123,
-0.018239403,
-0.015370853,
0.0045027332,
0.005134195,
-0.02576617,
-0.0023529083,
-0.0013660513,
-0.034549516,
0.0074950363,
0.015942024,
-0.01639896,
-0.013670032,
0.019419823,
0.00628923,
-0.017300142,
0.0041251257,
-0.010179541,
-0.034930296,
0.022174137,
-0.02260569,
0.0007480757,
-0.029675521,
0.0049914024,
0.0112266885,
0.00006460383,
-0.009183165,
-0.016614737,
-0.0029653308,
0.0035158764,
0.046886813,
0.19414745,
-0.013796959,
0.00920855,
0.029497823,
-0.02072717,
0.0090371985,
0.027162367,
0.02246607,
0.009176819,
0.00041489245,
-0.020892175,
-0.0027384488,
-0.010991873,
0.011861323,
0.018074397,
-0.04460213,
-0.02044793,
-0.0043980186,
0.02142527,
0.008586608,
0.00031553247,
-0.013035397,
-0.0090562375,
0.007996398,
0.028431635,
0.013796959,
0.0021672775,
0.02647696,
0.0489938,
-0.014482365,
-0.0035222229,
0.0006572436,
0.019051734,
0.017820543,
0.002557578,
0.0028034989,
0.012210372,
0.005134195,
0.001516777,
-0.0074759973,
-0.00008394036,
-0.012026329,
-0.026121566,
-0.030817863,
0.0046296604,
0.0051817927,
0.0012962414,
-0.018252095,
-0.004296477,
0.009741643,
-0.050618466,
-0.00060329965,
0.009862224,
0.0067461673,
-0.025816942,
-0.0024512766,
0.0090435445,
0.020498702,
-0.018112475,
0.020244848,
0.014621984,
0.014088891,
-0.010706288,
0.017706309,
-0.006466928,
0.012102485,
-0.017719002,
-0.0016405308,
0.014596599,
-0.008497759,
0.0054388195,
-0.021793356,
0.0026638792,
0.0073617627,
-0.014469672,
-0.009919341,
0.019610213,
0.018924808,
0.0058925836,
0.022719923,
-0.006942904,
-0.017439762,
0.013530413,
0.0064764475,
-0.00068342226,
-0.039321966,
-0.012597499,
0.012800583,
-0.014393516,
-0.012749812,
0.011156878,
-0.0044107116,
-0.024509594,
-0.02180605,
0.038687333,
-0.012242104,
-0.034651056,
0.006355867,
-0.010192234,
-0.00661924,
-0.00022132887,
0.07676542,
0.008167749,
0.021019103,
-0.013593876,
-0.030919405,
0.00094322587,
0.007907549,
0.002711477,
0.008751613,
0.002684505,
-0.00986857,
0.006213074,
-0.027136981,
-0.0042108013,
0.03838271,
0.02585502,
-0.029827833,
-0.016690893,
-0.032772537,
-0.008637379,
-0.01822671,
-0.008313715,
0.030538624,
-0.014203126,
-0.004582063,
-0.0038617523,
0.019864067,
-0.023291094,
-0.013010012,
0.004404365,
0.0035476082,
-0.006911172,
-0.007710812,
-0.0061464375,
0.0032128384,
-0.019051734,
0.0033223128,
-0.004693124,
-0.006961943,
-0.00430917,
-0.028939344,
-0.004020411,
0.031401727,
0.028177783,
-0.011391694,
0.005448339,
-0.0071904114,
0.014368131,
0.016500503,
0.0052516023,
0.008770652,
0.00010203737,
0.003033554,
0.016272034,
-0.027797,
0.008231212,
-0.025245769,
-0.010109731,
0.000016398862,
-0.014545828,
0.020562164,
0.0012494371,
-0.025588473,
-0.0017801505,
0.011962865,
-0.1568817,
0.014647369,
0.020549472,
-0.022618381,
0.010617439,
-0.014139662,
0.011639201,
0.025918482,
0.0025290195,
0.010934756,
0.0009725777,
-0.0056926734,
-0.017058982,
-0.032391757,
0.02199644,
0.0073236846,
0.00047954588,
0.03584417,
0.017058982,
0.012432494,
0.023329172,
-0.0090498915,
0.007767929,
-0.018302865,
0.0056069978,
0.016119722,
-0.0003795909,
-0.00051603734,
-0.017185908,
0.0013914367,
-0.012153255,
0.02990399,
0.0126355775,
0.010883986,
0.0054578586,
0.0038998304,
-0.005080251,
-0.007691773,
-0.016272034,
0.028253939,
0.019165969,
0.018404407,
0.015903946,
0.0184171,
-0.028000085,
0.00701906,
0.0067652063,
-0.0071142553,
0.010896678,
-0.013314636,
0.00017898683,
-0.007837739,
0.013111553,
-0.0018547201,
0.0126228845,
-0.018861344,
-0.044449817,
0.00041568576,
0.0052484293,
-0.0036332838,
-0.026248492,
-0.0036681888,
0.01756669,
0.019140584,
0.0021688642,
-0.031503268,
-0.007691773,
-0.010699942,
-0.024166891,
0.023684569,
-0.036199566,
-0.029523209,
-0.001154242,
-0.023253016,
0.015650092,
0.015942024,
-0.013631954,
-0.0014271348,
0.0032477432,
0.00788851,
0.0026559464,
-0.02274531,
-0.001770631,
-0.03206175,
0.008085246,
0.016195878,
0.006102013,
0.010788791,
0.0055308416,
-0.023900345,
0.016132414,
-0.02364649,
-0.005787869,
-0.00091228745,
0.0040711816,
0.013149632,
0.0050136144,
0.006505006,
-0.0075140754,
0.0024941145,
0.01954675,
0.00025087903,
-0.0155612435,
0.006796938,
0.028457021,
-0.022161445,
0.008897579,
0.005172273,
0.026806971,
-0.0133654075,
-0.0035127033,
0.016411655,
0.0010114491,
0.031147873,
0.029599365,
0.026070794,
0.022567611,
-0.011994597,
-0.009081623,
-0.0053975685,
0.03325486,
-0.012870393,
-0.002676572,
0.030690936,
0.010395317,
-0.014786989,
-0.12195141,
-0.00899912,
0.012311914,
-0.0001860273,
0.022440685,
0.03536185,
0.0050865975,
-0.0034302007,
-0.021247571,
0.018125167,
-0.010871293,
-0.008891232,
0.00457889,
-0.013073475,
0.036428034,
0.0011859736,
-0.018442485,
-0.03310255,
-0.02001638,
0.03571724,
-0.0148377605,
-0.030360926,
-0.010344546,
-0.009881263,
-0.0006215454,
0.016563967,
-0.010573015,
0.00046407664,
-0.0063653863,
-0.011702664,
-0.008243905,
0.0022799254,
0.0035000106,
0.0063653863,
-0.010452434,
0.009424326,
-0.0026527732,
-0.021729894,
0.029980145,
-0.019775217,
-0.0018959712,
0.007310992,
0.034422588,
-0.03947428,
0.0020451103,
-0.036580347,
-0.029269354,
0.009703565,
0.0055467077,
-0.02374803,
-0.030233998,
-0.0019530884,
-0.031173259,
-0.0017262065,
0.006387599,
-0.022351835,
-0.016703587,
0.011664586,
-0.013796959,
0.012781544,
-0.006003645,
0.00748869,
-0.012419802,
0.009824146,
0.025093457,
-0.01973714,
-0.015104307,
-0.04089586,
0.014545828,
-0.0335341,
-0.002241847,
0.0040838746,
-0.026451577,
0.034422588,
-0.015929332,
0.01723668,
-0.011480542,
0.0022243948,
0.041251257,
-0.009265667,
-0.021742586,
-0.002481422,
0.000106003834,
-0.01850595,
0.0074633043,
0.01273712,
0.008256597,
-0.00258455,
-0.0013295597,
-0.034828756,
-0.009449711,
0.0356157,
-0.012838661,
0.0036396303,
0.031528655,
0.02939628,
0.0010717394,
-0.008707189,
0.015535858,
0.011017259,
-0.016868591,
0.0005247636,
-0.047267593,
0.009614716,
0.0026020024,
0.0024258913,
-0.014520443,
-0.008021783,
0.008453335,
-0.00068342226,
0.0021910765,
-0.014139662,
-0.037951156,
0.009970112,
-0.015726248,
-0.019254819,
-0.028000085,
-0.0103382,
0.026400805,
0.000762355,
0.025981946,
0.004547158,
-0.0028812417,
0.013022705,
0.015294697,
0.017401684,
0.02025754,
0.0059687397,
0.016843205,
0.017452456,
-0.0051088096,
0.014253896,
0.026299264,
-0.035793398,
0.0045884093,
0.008637379,
-0.017630152,
-0.0173763,
-0.00046169676,
0.014647369,
-0.0024861817,
0.0009035612,
-0.008580262,
0.0078187,
-0.012730773,
-0.021323727,
-0.0063780793,
0.008002744,
-0.04267284,
0.0074188802,
0.010084346,
-0.029675521,
0.035920326,
0.012749812,
-0.010420702,
-0.006815977,
-0.0368342,
-0.011709011,
0.0030256212,
0.016335499,
-0.007945627,
-0.029294739,
0.010020883,
-0.008802384,
-0.0076663876,
-0.014088891,
-0.0042615724,
-0.008948349,
0.008770652,
0.004934285,
0.0033445251,
0.004023584,
0.0098178,
-0.021742586,
-0.022643767,
-0.011981904,
-0.004563024,
0.0015643747,
-0.0054927636,
0.022897622,
-0.012337299,
0.020041766,
0.021019103,
0.00417907,
-0.01766823,
-0.000188903,
0.03170635,
0.0020514568,
-0.005832293,
0.00357934,
-0.008611993,
-0.0000019956287,
-0.015840484,
0.004845436,
0.0038998304,
0.021234877,
0.028253939,
0.0401343,
0.0069682896,
-0.005990952,
0.006308269,
0.023138782,
0.025867712,
-0.00075521535,
-0.0141015835,
-0.02637542,
-0.018874036,
0.0026733987,
-0.0012192919,
-0.01785862,
-0.029370895,
0.0067144353,
0.003203319,
0.033153318,
0.028177783,
-0.0018293347,
0.0040711816,
0.024522286,
-0.0347526,
-0.0019499152,
-0.012286528,
0.03203636,
0.0037379987,
0.014241204,
0.0029367723,
0.0015223301,
0.024192275,
-0.00873892,
0.03122403,
-0.007253875,
0.01530739,
-0.0009979631,
-0.0009154606,
-0.019254819,
-0.03099556,
-0.0015048776,
-0.01184863,
-0.033940267,
0.0018927981,
0.020600244,
-0.015193156,
0.051278487,
-0.015485087,
-0.018670954,
0.0009908235,
0.027847772,
0.012140563,
-0.005115156,
0.0048137046,
-0.012102485,
0.0014160287,
0.00204987,
0.0034619325,
-0.010223965,
-0.03942351,
-0.0009892369,
0.037418064,
-0.0026115219,
0.0078187,
-0.028279323,
0.0026860915,
0.0389158,
-0.00043869126,
0.013974657,
-0.0035380886,
-0.030132458,
-0.01874711,
0.034777984,
0.01146785,
0.011753435,
-0.035793398,
-0.01714783,
0.016005488,
-0.02642619,
-0.030411696,
0.017541304,
-0.0033508714,
-0.013035397,
0.0021561715,
0.006847709,
-0.019749833,
0.015815098,
0.040261228,
-0.033178706,
-0.021602966,
-0.027568532,
-0.0051278486,
-0.01601818,
-0.016043566,
-0.012324607
] |
The control of cell growth and polarity depends on a dynamic actin cytoskeleton that has the ability to reorganize in response to developmental and environmental stimuli. In animals and fungi, formins are just one of the four major classes of poly-L-proline-containing (PLP) proteins that form part of the signal-transduction cascade that leads to rearrangement of the actin cytoskeleton. Analysis of the Arabidopsis genome sequence indicates that, unlike animals and fungi, formins are the only class of conserved profilin-binding PLP proteins in plants. Moreover, plant formins show significant structural differences compared with their animal and | [
-0.0111458665,
-0.01599339,
-0.0031508903,
-0.027476177,
-0.04348332,
0.017904896,
-0.02115033,
0.01732732,
-0.005841094,
-0.017616108,
0.041420545,
0.022580523,
0.006298343,
0.014164396,
-0.012122247,
0.01695602,
0.024533283,
0.018331204,
-0.029153902,
0.036057327,
-0.022374244,
0.035809793,
0.0045243558,
-0.03878019,
-0.006783095,
0.0071990886,
0.006291467,
-0.03498468,
0.012197883,
-0.026774833,
-0.0111389905,
-0.014439433,
0.017506093,
-0.000072358314,
-0.011331516,
-0.0021109076,
0.027159885,
-0.006924052,
0.015113273,
-0.0017559382,
0.013531811,
0.023350624,
-0.014645711,
-0.018867524,
-0.0053941594,
-0.016625974,
-0.00077182206,
0.023419384,
-0.021397864,
-0.0017164015,
0.01592463,
0.023818187,
0.00094543904,
-0.026348526,
-0.006466803,
-0.03490217,
0.008471134,
0.011716568,
0.010066347,
-0.019582622,
-0.008354243,
0.011723444,
-0.01501701,
0.021837922,
-0.0048475238,
0.029318923,
-0.0059958026,
0.008505513,
-0.006453051,
-0.021549134,
0.041668076,
0.029566457,
0.003432803,
-0.010031967,
0.017299816,
-0.016969772,
-0.031794254,
-0.008141089,
-0.0154708205,
0.023268115,
-0.000355614,
-0.02128785,
0.004390275,
0.024560787,
0.003537661,
-0.014178148,
0.014796981,
0.019527614,
0.017134793,
-0.014081885,
0.002923985,
0.049369108,
0.029868998,
0.029841494,
-0.022979325,
0.000281483,
-0.009227485,
0.026651068,
-0.017726123,
-0.00829236,
0.002324061,
0.010912086,
0.011441532,
-0.0071028257,
-0.013648702,
0.0138206,
0.01994017,
-0.022608025,
0.02920891,
-0.030886633,
-0.03407706,
0.033004418,
0.0016124033,
-0.046123672,
0.018633744,
0.0019544803,
0.017162297,
0.004514042,
-0.016158413,
-0.0065836934,
0.023034332,
0.040237885,
0.023295619,
-0.014191899,
0.05140438,
0.02024271,
0.005603875,
0.010451399,
-0.01225289,
-0.0027263025,
0.02255302,
0.02152163,
0.017506093,
0.007075322,
0.00964004,
-0.0073503586,
-0.022291733,
-0.035232216,
-0.030474078,
-0.021865426,
0.008876813,
0.03407706,
-0.017244808,
0.014810733,
-0.019610124,
0.0026867657,
0.007501629,
0.010808947,
-0.0035050004,
-0.013579942,
0.022332989,
-0.0025526853,
0.020600257,
-0.008808054,
0.008464258,
0.008423002,
-0.009729427,
0.036277354,
-0.017464837,
0.0034138944,
-0.009289368,
0.005858284,
0.0051569403,
0.00039515054,
0.02226423,
0.021452872,
0.001683741,
0.029181406,
0.004400589,
0.01378622,
0.017794881,
0.010540786,
-0.050909314,
0.018262444,
-0.009282492,
0.0007215419,
-0.00045037278,
0.0057276418,
-0.014260659,
-0.009619412,
0.009901325,
-0.0038058218,
0.005672634,
0.010829574,
-0.0070203147,
-0.0063120946,
0.013511184,
-0.017891144,
0.000093738134,
0.0061608246,
-0.02539965,
0.011785327,
0.018289948,
-0.0016691296,
-0.6372053,
-0.026981112,
0.021425368,
-0.025825957,
0.0035651647,
0.028301287,
-0.004393713,
-0.007969191,
-0.023226859,
0.014563199,
-0.02495959,
0.0074053663,
0.017011026,
-0.03817511,
-0.019238824,
-0.030501582,
-0.0032213686,
-0.028631331,
0.022291733,
0.010808947,
-0.021205338,
-0.0013107223,
-0.004376523,
0.005964861,
0.00003067305,
0.020655265,
0.031106664,
-0.017451085,
-0.008120461,
0.017794881,
-0.038010087,
0.02637603,
-0.010912086,
0.0036545517,
0.03638737,
0.0046068667,
-0.028933872,
0.030446574,
0.030419072,
0.03303192,
-0.01769862,
0.009791311,
0.015402061,
-0.0047925166,
-0.030721612,
-0.0018599364,
0.0005427679,
0.00878055,
0.0321243,
0.0020541812,
0.007233468,
0.00638773,
-0.015553332,
-0.0075222566,
0.018509977,
0.02181042,
0.028328791,
-0.017616108,
0.003448274,
0.017382326,
-0.0040224134,
0.0136968335,
-0.031326693,
-0.02794374,
0.0033038796,
-0.01651596,
-0.026403533,
0.014109388,
0.0036511137,
0.0040258514,
0.028878866,
0.017354824,
-0.0006987654,
-0.012431663,
-0.007240344,
0.039935347,
-0.0037405007,
0.0021177835,
-0.0003728038,
0.02517962,
0.01800116,
-0.004431531,
-0.02368067,
-0.0024598604,
0.014398177,
0.0034138944,
-0.015745858,
0.015594587,
-0.02077903,
-0.005170692,
0.006019868,
-0.0052875825,
-0.009557529,
-0.028273784,
-0.04870902,
0.008904316,
-0.008147965,
-0.01173032,
-0.016763493,
-0.026774833,
-0.005266955,
-0.014563199,
0.009096842,
0.0096950475,
0.004727195,
-0.002834598,
-0.030226545,
0.013105504,
0.03905523,
-0.029428938,
-0.0019647942,
-0.004318078,
0.003364044,
-0.009358128,
-0.0062364596,
-0.023543151,
0.004304326,
0.018399963,
-0.001208443,
-0.012094744,
-0.005957985,
-0.013201767,
-0.018564984,
0.02174166,
0.025042102,
0.018523728,
0.0067727813,
-0.020751527,
-0.0112902615,
-0.0007340045,
0.00035905195,
0.011984729,
0.036222346,
-0.023048084,
0.01385498,
0.025220875,
0.017203553,
0.01366933,
0.031024152,
-0.01987141,
-0.021879178,
-0.000578007,
-0.006549314,
-0.022745544,
-0.008546769,
-0.028961375,
-0.037707545,
0.011310888,
0.009296244,
0.024835823,
-0.0049541006,
0.0077216583,
-0.007240344,
0.025537169,
0.020944053,
-0.0020369913,
-0.012686073,
-0.015553332,
0.015745858,
-0.008759922,
-0.0077010305,
-0.009619412,
-0.021246593,
0.01277546,
-0.0020060497,
0.00945439,
0.021054069,
0.0037680042,
0.0025251817,
-0.030584093,
0.0041564936,
-0.01412314,
-0.024519531,
0.025110861,
-0.009571281,
0.016598472,
0.012012233,
0.01001134,
-0.022896815,
-0.00689311,
-0.0039742817,
-0.030281553,
-0.020957805,
-0.022085456,
0.011922846,
0.022580523,
0.023474392,
0.011716568,
-0.021604141,
0.024808321,
-0.0021005936,
0.0026369153,
0.007694155,
0.010767691,
-0.008134213,
-0.02152163,
0.011517166,
0.018688751,
0.00024581415,
0.01592463,
-0.002239831,
-0.023171851,
-0.003458588,
-0.031354196,
0.014796981,
-0.01919757,
-0.014893243,
-0.030529086,
0.018468723,
0.017231056,
0.0031199488,
-0.006477117,
-0.01897754,
-0.019706387,
0.009385631,
-0.0026472292,
-0.015374558,
-0.0051363125,
-0.027311156,
0.0013064248,
-0.008567397,
0.0036304859,
0.029291421,
-0.01277546,
0.0012419631,
0.00024431004,
-0.0014637115,
0.018991292,
-0.005940795,
-0.010451399,
-0.015278295,
0.008484886,
0.01378622,
0.016405946,
-0.0014164395,
0.0015376277,
0.03333446,
-0.0040258514,
0.04595865,
-0.003802384,
-0.0012625909,
0.025220875,
-0.013490556,
0.0040052235,
-0.004806268,
-0.028108763,
0.030749116,
0.0057379557,
0.01154467,
0.013160511,
-0.0030718173,
0.023405632,
-0.008911192,
-0.0034104565,
-0.011496538,
-0.010547661,
0.0055557434,
0.0062330216,
0.059132915,
0.02398321,
-0.0032437153,
-0.00021605431,
0.0060920655,
-0.016749742,
0.009193106,
-0.008141089,
0.002238112,
-0.017217305,
-0.01934884,
-0.0053907214,
-0.020132694,
0.010946465,
0.0410905,
-0.022566771,
0.01860624,
0.012466043,
0.012204759,
0.0039020847,
0.0024959592,
0.004479662,
0.000333697,
-0.04243818,
0.002159039,
0.028933872,
-0.0065046204,
-0.012197883,
-0.033581994,
0.019211322,
-0.0025836271,
0.0070203147,
-0.008766798,
-0.009096842,
-0.0011964102,
0.010465151,
0.001205005,
-0.00952315,
-0.013318658,
-0.008615528,
0.008429878,
-0.013153636,
-0.0029136713,
-0.006814037,
-0.007914185,
-0.0017757064,
0.05874786,
0.0063189706,
-0.010265749,
0.010100727,
-0.00930312,
-0.03085913,
-0.0018805641,
0.0070409426,
0.0016648322,
-0.0132223945,
-0.0085949,
0.002765839,
0.024698306,
-0.008161717,
0.032014284,
0.012802963,
-0.020503994,
-0.030061522,
0.00023657463,
0.015567084,
0.016020894,
0.026609812,
0.006865606,
0.008333615,
-0.016172165,
0.0010992878,
-0.016502209,
-0.0058067148,
-0.0017516407,
-0.02555092,
0.0074603735,
-0.015484572,
0.0070340666,
-0.008457382,
-0.0010726436,
0.020572754,
-0.015553332,
-0.013126132,
-0.005762021,
0.0047787647,
0.0070271906,
-0.008505513,
0.017368574,
0.038230117,
0.017368574,
0.01919757,
-0.010389515,
0.029016383,
-0.00015782386,
0.0050228597,
0.014906995,
0.003446555,
-0.0052841445,
0.012376657,
-0.024010714,
-0.029043887,
0.0073641106,
0.036222346,
-0.002762401,
0.02047649,
0.011909094,
0.025289634,
0.003358887,
-0.0116203055,
-0.011008348,
-0.020971557,
-0.0017456242,
0.00080878014,
0.016350938,
-0.025385898,
0.009564405,
-0.008519265,
0.0005548008,
-0.009096842,
0.021274097,
-0.03033656,
0.012307897,
0.0014301914,
0.00046627334,
-0.0067659053,
0.011063356,
-0.027146133,
0.019885162,
-0.010293253,
0.0032557482,
-0.01225289,
-0.01806992,
-0.005703576,
-0.010045719,
-0.008615528,
0.014329418,
-0.05462231,
-0.014425681,
-0.0006007835,
0.014164396,
0.027654951,
-0.0050228597,
-0.03077662,
0.0043593333,
0.009103718,
0.0071990886,
-0.015952135,
0.0017619545,
-0.02084779,
-0.016075902,
0.021480374,
0.0014018283,
0.008952448,
-0.0090624625,
0.0101694865,
-0.004713443,
-0.01749234,
0.003530785,
-0.013408044,
-0.036882438,
-0.010451399,
0.017767377,
0.03308693,
-0.00012494836,
-0.01629593,
0.0029789924,
-0.042355668,
-0.01740983,
-0.04362084,
-0.014288162,
-0.0072815996,
0.009179354,
-0.016722238,
-0.02846631,
-0.0111458665,
-0.003357168,
-0.008285484,
0.012555431,
0.026389781,
0.029731479,
0.03608483,
0.0043455814,
0.02428575,
-0.0020576192,
-0.020957805,
-0.008876813,
-0.02010519,
0.02010519,
-0.004565611,
-0.045326065,
0.016502209,
0.026912352,
-0.009096842,
-0.026431037,
-0.007597892,
-0.026884848,
0.032371834,
-0.0018840021,
-0.024629546,
-0.0054079113,
-0.008333615,
-0.0080929585,
0.005610751,
-0.0062742773,
-0.008340491,
-0.0022192032,
-0.018468723,
0.029126398,
-0.016172165,
0.0019527613,
-0.035754785,
0.002772715,
0.02779247,
0.01643345,
0.019527614,
-0.012541679,
0.014686965,
-0.0049609765,
0.0034052995,
-0.02255302,
-0.028823858,
0.004393713,
-0.0358648,
0.049726654,
0.019073803,
0.044996023,
0.01397187,
-0.013772468,
0.027448673,
0.0076116435,
-0.002329218,
0.0010236526,
-0.0039227125,
-0.052174482,
0.01853748,
0.005803277,
0.024863327,
0.034792155,
-0.02951145,
0.010582041,
0.022896815,
-0.032839395,
-0.02218172,
-0.0017636735,
-0.024780817,
-0.012452291,
0.008959324,
-0.007907309,
-0.005449167,
-0.030831626,
-0.009928829,
0.009475018,
0.0073159793,
-0.026252264,
-0.021177834,
0.025509665,
-0.028356295,
0.036854934,
-0.0013726056,
0.026472293,
-0.0061333207,
-0.016598472,
-0.010403267,
-0.006982497,
0.00552824,
-0.027916236,
0.009550653,
0.0074397456,
0.0034207704,
-0.017148545,
0.013559314,
-0.00026235933,
-0.027751215,
0.006954993,
-0.01732732,
0.011166494,
-0.017987408,
-0.014453185,
-0.05209197,
0.006714336,
-0.015333302,
-0.0026867657,
0.023199355,
0.011249006,
-0.02255302,
0.029236414,
-0.0012875161,
0.012967986,
-0.0054044733,
0.008512389,
0.02570219,
-0.008677412,
-0.025248379,
-0.005748269,
-0.023336872,
0.0008981671,
0.016350938,
0.009041836,
-0.0061848904,
-0.03294941,
-0.010857078,
0.019582622,
-0.01950011,
-0.041805595,
0.0073434827,
-0.0010743625,
0.03451712,
0.0044418443,
0.01636469,
-0.035892304,
0.019761395,
-0.0025440904,
0.007831673,
-0.0072540957,
-0.014109388,
-0.01950011,
0.005418225,
-0.0042011873,
0.022154216,
-0.0034259274,
-0.024533283,
0.031216677,
-0.008753046,
0.0037748802,
0.009110594,
-0.011083984,
0.01569085,
0.015044513,
0.0116203055,
0.016543465,
0.02713238,
-0.0063224086,
-0.020999061,
-0.022676785,
0.04131053,
-0.02592222,
0.006459927,
0.0016063869,
0.016639726,
0.013442424,
-0.023653166,
0.0111389905,
0.00088269624,
-0.032619365,
-0.0011422622,
0.048599005,
0.017877392,
0.008168593,
-0.0033399782,
-0.02061401,
0.009124346,
-0.0265273,
-0.0017146827,
0.0018599364,
-0.032289322,
-0.006906862,
-0.0034826535,
0.014975755,
0.0132292705,
0.0021727907,
-0.0034964054,
-0.017822385,
0.04279573,
-0.017354824,
0.018798767,
-0.008361119,
-0.00450029,
-0.038450144,
0.0135524385,
0.0061780144,
-0.029126398,
-0.005500736,
-0.021494126,
-0.030611597,
0.03624985,
0.005689824,
0.018523728,
0.005438853,
-0.026087241,
-0.0017301535,
0.0014069852,
0.00862928,
-0.0052463273,
0.0011585925,
-0.007948563,
-0.027531184,
0.0014516787,
0.00982569,
-0.009406259,
-0.014769477,
0.011503414,
-0.032014284,
0.015113273,
-0.0019768272,
-0.00915185,
-0.015773362,
0.0051672542,
-0.01124213,
0.0034826535,
-0.009282492,
-0.03729499,
-0.012060364,
0.006621511,
0.024161983,
-0.013469928,
-0.003432803,
0.014906995,
0.017891144,
0.0073641106,
-0.022401748,
-0.006899986,
0.014356921,
-0.025523417,
-0.009660668,
0.0017593761,
-0.022608025,
0.044638474,
0.0037473766,
-0.0029755544,
-0.004916283,
-0.008484886,
-0.04521605,
-0.017244808,
-0.008684287,
0.0020919987,
-0.003795508,
-0.0071922126,
-0.0028827295,
0.011682188,
-0.00500567,
0.011077108,
0.015127025,
0.013848104,
0.008828682,
0.0024323568,
0.014659462,
-0.0039674058,
-0.024079472,
-0.010389515,
0.020875294,
-0.015883375,
-0.010279501,
0.0077216583,
-0.006979059,
0.0073916144,
-0.02115033,
0.012108495,
0.019335087,
-0.00007896565,
0.021411616,
-0.0116134295,
-0.017464837,
-0.006535562,
0.008553645,
-0.011771576,
0.01225289,
-0.00603362,
0.0042046253,
0.020737775,
0.005352904,
-0.03795508,
0.012197883,
-0.025248379,
0.0351222,
-0.001594354,
0.009866945,
0.025647182,
0.020091439,
-0.010148859,
-0.027929988,
-0.0057276418,
-0.025688438,
-0.018523728,
-0.0026592622,
0.0040774206,
0.006549314,
0.017822385,
0.009124346,
-0.012864847,
-0.0047065676,
0.00674184,
0.019225072,
-0.015965886,
0.035809793,
-0.0074191177,
-0.0023051524,
0.0008160858,
-0.000097337244,
-0.0031079159,
-0.021837922,
0.00019757527,
-0.0076460233,
0.008381747,
0.0134493,
0.0063636643,
-0.008704915,
0.02152163,
-0.015745858,
-0.0035479749,
-0.0136968335,
0.0031629233,
0.1726131,
-0.010527034,
0.026692322,
0.026321022,
-0.0019785461,
0.019417599,
-0.010293253,
-0.022071704,
-0.0033434161,
0.009076214,
0.0050950567,
0.012527927,
-0.007591016,
-0.00029416048,
0.013978746,
0.0016639727,
-0.009028084,
0.018138677,
-0.02533089,
0.011214626,
0.017767377,
-0.024189487,
0.023281867,
0.0008315566,
0.026211008,
-0.014425681,
-0.0124247875,
-0.0039708437,
-0.010217617,
0.014075009,
-0.020490242,
-0.0019252576,
-0.016254675,
-0.00881493,
0.030941641,
0.004459034,
0.017506093,
0.010410143,
0.01582837,
-0.006827789,
0.021659149,
0.0062398976,
0.012555431,
-0.008051703,
-0.0016218576,
-0.013463052,
-0.008567397,
-0.014521943,
-0.016653478,
0.02890637,
-0.055722456,
0.019596374,
0.023226859,
0.004390275,
0.007150957,
0.0072059645,
-0.0062467735,
-0.004630932,
-0.014480688,
0.026128497,
-0.014563199,
0.0020455862,
-0.0039674058,
-0.0007138065,
-0.032234315,
0.0038608292,
-0.009646916,
0.0077216583,
0.029098894,
-0.025069606,
-0.027311156,
0.0060955035,
-0.014439433,
0.004479662,
-0.0061333207,
-0.009241236,
0.032371834,
0.020971557,
0.04238317,
0.039440278,
0.0032935657,
0.0034912485,
-0.040375404,
0.0035514128,
-0.000029142084,
-0.024065722,
0.023226859,
-0.003279814,
-0.023996962,
-0.026389781,
0.024010714,
-0.0072747236,
-0.00964004,
-0.0049781664,
0.012789211,
-0.012032861,
-0.009516274,
0.0044452823,
-0.018179933,
-0.014301914,
-0.040540427,
0.050221723,
0.026321022,
0.019926418,
-0.022704288,
-0.0029927443,
-0.010547661,
0.014150644,
0.001125932,
-0.035012186,
0.009248112,
-0.01363495,
0.005961423,
-0.019073803,
-0.01606215,
-0.0048681516,
0.0190463,
-0.015938383,
0.030501582,
-0.00060293224,
-0.0033141936,
-0.020889046,
0.010430771,
0.0075703883,
0.0034259274,
0.016722238,
-0.02002268,
0.016089654,
-0.013126132,
-0.048076436,
0.0047753267,
-0.0061573866,
-0.0005586685,
-0.0076528993,
-0.018496225,
-0.0050159837,
0.004242443,
-0.004558735,
-0.0008981671,
-0.0072197164,
-0.021782916,
0.012349153,
0.0069515556,
-0.013978746,
-0.00982569,
0.019912666,
0.019678883,
0.034104563,
-0.019775147,
-0.028356295,
-0.0051466264,
0.00020337683,
0.0020008928,
-0.0074534975,
0.0095300255,
-0.004455596,
-0.020875294,
-0.034682143,
0.03085913,
0.008423002,
-0.0418331,
-0.00878055,
0.02368067,
0.014920747,
0.012479795,
-0.0023704735,
-0.17503342,
0.018179933,
0.014659462,
-0.010176362,
0.014439433,
0.01397187,
-0.013029869,
-0.0060645617,
0.016419698,
0.0053047724,
0.018619992,
0.010313881,
-0.029428938,
-0.03457213,
0.0023567216,
0.000864647,
0.00847801,
0.0351222,
0.007666651,
0.008326739,
0.014962003,
-0.015952135,
0.006872482,
-0.0071372055,
-0.0000067550545,
0.010561413,
0.026981112,
0.008182345,
0.00026386345,
-0.03900022,
0.003458588,
0.0017739874,
0.048819035,
-0.0031852701,
-0.009199982,
-0.0106576765,
-0.0113040125,
-0.025674686,
-0.012349153,
0.012053488,
0.009585033,
0.025963474,
0.0066937082,
-0.0087324185,
0.014618207,
0.02742117,
-0.006655891,
-0.012507299,
0.00926874,
-0.0041908734,
0.021576637,
-0.011152742,
0.015374558,
0.044033393,
0.034104563,
0.024450772,
-0.0060748756,
0.010733311,
-0.013765592,
0.0013390855,
-0.010884582,
-0.0077285343,
0.028658835,
0.010808947,
0.0034104565,
0.0037233108,
-0.023281867,
0.0012660288,
-0.028961375,
0.014191899,
0.012851095,
0.0021109076,
0.014370673,
-0.030611597,
0.030694108,
-0.0048853415,
-0.010664552,
-0.0005964861,
-0.02159039,
0.013091752,
-0.014741973,
0.026197257,
-0.03564477,
-0.00534259,
-0.004541545,
-0.02405197,
0.008010447,
0.019527614,
0.006552752,
0.010973969,
0.03443461,
-0.011716568,
-0.0096950475,
-0.004926597,
0.02907139,
0.019293832,
-0.009832566,
-0.027489929,
-0.00057242037,
-0.005858284,
0.012431663,
0.005610751,
-0.01651596,
-0.0042768223,
-0.00031564772,
0.0009798186,
-0.0061608246,
-0.000041846422,
0.06270839,
-0.017162297,
0.012074116,
-0.003279814,
0.019060051,
0.014150644,
-0.011929722,
0.0057345177,
0.0135524385,
-0.0038058218,
-0.0042527565,
-0.010478903,
0.03900022,
0.019252576,
0.0025612803,
0.0054663564,
0.011001472,
-0.021274097,
-0.12860721,
-0.003616734,
-0.010052595,
0.04095298,
0.0037301867,
0.008457382,
-0.0017653925,
-0.0026644191,
-0.017341072,
0.015938383,
-0.0040327273,
-0.014948251,
0.010004464,
0.009619412,
-0.004338706,
0.0087392945,
-0.00091105944,
0.000022091579,
-0.0048990934,
0.013043621,
-0.0030305618,
0.007886681,
-0.00908309,
-0.0017593761,
0.0041805594,
-0.00070821977,
-0.011503414,
0.014576951,
0.00086077926,
0.005748269,
0.012356029,
-0.020091439,
0.028191272,
-0.009990712,
-0.012142875,
-0.007082198,
-0.01553958,
-0.024120728,
0.026472293,
0.022387996,
0.009901325,
-0.0014989506,
0.018344956,
-0.0069309277,
0.023364376,
-0.023130596,
-0.0053185243,
0.009103718,
-0.0052841445,
-0.0071234535,
-0.037047457,
-0.035479747,
-0.043648344,
-0.01673599,
0.025454657,
-0.022470508,
-0.0072678477,
0.025000846,
0.008670536,
-0.00084144075,
-0.026114745,
0.0074534975,
-0.014178148,
0.01142778,
0.037102465,
-0.005930481,
0.00056253624,
-0.03033656,
0.046453718,
-0.029703975,
-0.019843906,
0.008209849,
-0.009144974,
-0.0025045539,
-0.018317452,
-0.011750948,
-0.028851362,
-0.01875751,
0.0070306286,
-0.009578157,
0.0012883756,
-0.02981399,
-0.0003697956,
-0.025427153,
0.017588604,
0.006123007,
0.0343796,
-0.01673599,
0.012177255,
-0.008512389,
-0.010630173,
0.019060051,
0.019857658,
-0.002420324,
-0.019843906,
0.013256774,
0.00911747,
-0.006803723,
0.0062020803,
0.031436708,
-0.05052426,
-0.018042415,
-0.058637846,
0.014013126,
0.00948877,
0.011771576,
0.0069103,
-0.00024431004,
0.0039123986,
0.0071372055,
-0.002923985,
0.038202614,
-0.023598159,
0.0047684507,
0.0009798186,
-0.021604141,
-0.033994548,
-0.029841494,
0.043758355,
-0.030474078,
0.030309057,
0.019458855,
0.0017413268,
0.0025801891,
0.029236414,
0.0095300255,
-0.009585033,
-0.011565298,
-0.01912881,
0.005500736,
-0.014769477,
0.012019109,
0.0043421434,
-0.03107916,
-0.0064289854,
-0.0056520062,
-0.014233155,
-0.024313254,
-0.0220442,
0.018276196,
0.012706701,
0.0072059645,
0.004489976,
-0.03966031,
0.0076185195,
-0.0024736123,
0.0053185243,
-0.0026609811,
-0.03281189,
0.00081952376,
0.001683741,
-0.012466043,
0.011991605,
0.004459034,
-0.013236146,
-0.032536853,
-0.0064977445,
-0.005504174,
-0.0060164304,
-0.015842121,
0.01258981,
-0.015195784,
0.0037233108,
0.016048398,
0.009846318,
-0.0005548008,
-0.021480374,
0.004744385,
-0.035589762,
-0.009976961,
-0.008670536,
-0.031244181,
-0.02937393,
0.02339188,
0.013655578,
-0.0036407998,
-0.0019132248,
0.01531955,
-0.018111173,
-0.022057952,
-0.009729427,
0.03429709,
0.012686073,
0.021507878,
-0.012596686,
0.02517962,
0.025014598,
-0.004397151,
0.008154841,
0.014604455,
0.012981737,
0.008216725,
-0.0036614276,
0.018317452,
0.009591909,
-0.007790418,
0.014906995,
0.014040629,
-0.016103406,
0.012782336,
0.0052085095,
-0.0072884755,
0.0047718887,
-0.018317452,
0.008450506,
-0.029703975,
-0.016997274,
0.007144081,
-0.021755412,
-0.033967048,
-0.006982497,
0.001899473,
0.0062398976,
-0.02435451,
0.0130642485,
-0.003021967,
0.014219403,
0.03165674,
0.010066347,
-0.016790997,
-0.00012989042,
-0.0019183818,
0.026156,
0.00918623,
0.0074810013,
0.0038058218,
0.0012660288,
0.014920747,
0.002324061,
-0.011524042,
0.0084092505,
-0.0019183818,
0.022429252,
-0.006549314,
-0.046481222,
-0.01875751,
0.011888466,
-0.0073228553,
0.0014379268,
0.010313881,
-0.017299816,
0.090762146,
-0.016914764,
-0.0026455102,
0.012301021,
-0.015842121,
0.006539,
-0.012032861,
0.013119256,
-0.019376343,
-0.011152742,
0.0030804123,
-0.00069231924,
-0.002676452,
-0.025220875,
-0.007233468,
0.024244495,
-0.0119434735,
0.021301601,
-0.011950349,
-0.028521318,
0.023501895,
-0.02106782,
-0.00018060034,
0.027861228,
-0.008031075,
0.0029944633,
-0.0073709865,
0.007852301,
0.025303386,
0.0049850424,
-0.015113273,
-0.0036064202,
-0.029318923,
-0.0016992118,
0.0059923646,
0.0050194217,
-0.005672634,
-0.015965886,
-0.015264543,
0.014384425,
-0.025358394,
0.0015247354,
-0.014576951,
-0.01980265,
0.008347367,
-0.0028689778,
0.016997274,
-0.016543465,
-0.020875294
] |
The weight lowering potential of glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) is inter-individually different and clinically unpredictable. The potential role of genetic variability of GLP-1R on body weight response to GLP-1 RAs in obese women with polycystic ovary syndrome (PCOS) has not yet been evaluated. Fifty-seven obese women with PCOS (aged 30.7 ± 7.0, BMI 38.6 ± 5.3 kg/m2) were assigned to liraglutide 1.2 mg QD s.c | [
-0.02188905,
-0.011966288,
0.030227734,
-0.0074540717,
0.013879523,
0.009346734,
-0.024467459,
-0.011458835,
-0.044381555,
-0.021052437,
0.02899339,
0.004255061,
-0.019941527,
0.010265635,
-0.012254301,
0.009477026,
0.030529464,
-0.008057529,
0.005815136,
0.005386544,
-0.0021412454,
-0.013001766,
0.005959143,
-0.0036413174,
-0.015895618,
0.005503121,
0.012713752,
-0.032147825,
0.013138915,
-0.018816901,
0.001723797,
0.01027935,
-0.02283538,
0.01686938,
-0.006110007,
-0.01315263,
-0.0045362175,
0.0059900014,
0.004697368,
-0.030694043,
0.027279021,
0.01562132,
0.010937667,
0.032394696,
-0.02158732,
-0.0009977621,
0.009675892,
-0.0071180556,
-0.0024961196,
0.017568842,
-0.008667844,
0.02264337,
-0.009278159,
-0.012487455,
-0.0055888393,
-0.0014092104,
0.01784314,
0.020599844,
0.010642796,
-0.029541988,
0.01342693,
0.00082075363,
-0.016169919,
0.009195869,
0.007138628,
0.015964193,
0.0077763726,
0.0289111,
0.00688833,
-0.002619554,
0.025509793,
0.041199688,
-0.0023263972,
0.0034647374,
0.019776948,
-0.020490125,
-0.011794851,
-0.00019865237,
0.008537552,
-0.0014332115,
0.017911715,
0.005568267,
0.009367306,
0.035631422,
0.004330493,
0.011911428,
-0.0029950007,
0.0061854394,
-0.030364884,
-0.0057774195,
-0.01950265,
0.00091547245,
0.013927525,
0.022657085,
0.00031051488,
0.004591077,
-0.0046905107,
0.010299922,
-0.003984191,
-0.0071454854,
-0.00013747088,
0.03812754,
-0.008359258,
-0.014386975,
-0.013893237,
-0.02769047,
-0.020764424,
0.006799183,
0.018912906,
-0.0021223875,
-0.014098962,
0.06292416,
-0.0017572271,
-0.0010946239,
-0.0071317703,
-0.017047673,
0.013769803,
0.018652322,
-0.0038607565,
-0.027375026,
0.0312975,
0.006140866,
0.032504413,
0.0005781706,
0.0006836042,
0.00015986481,
-0.011047387,
0.0069329035,
-0.014853284,
0.0075843637,
0.000001277405,
0.017198538,
0.010491932,
-0.0107662305,
-0.023178253,
0.01451041,
-0.011294256,
-0.01700653,
-0.035247404,
-0.009051862,
0.0051328177,
0.032806143,
-0.03151694,
0.020874143,
-0.030118015,
0.039663617,
0.029624278,
0.007625508,
-0.00843469,
-0.00071832014,
-0.004001335,
0.0045122164,
0.020695848,
-0.00073974975,
0.023068534,
-0.00333616,
0.017472837,
0.04525931,
-0.026867574,
-0.0065797437,
-0.0052596806,
-0.0011331972,
-0.013673798,
0.02291767,
0.007303207,
0.009970764,
0.0013252064,
-0.021422742,
0.00069260463,
0.009312446,
0.0061442945,
0.024124585,
-0.01141769,
0.018899191,
-0.0051465323,
0.03165409,
0.0050813863,
-0.016128773,
0.004213916,
0.008592412,
-0.028664231,
0.017870571,
0.015977908,
0.0036550323,
-0.029596847,
0.001122911,
0.01678709,
-0.02655213,
0.0028029915,
-0.035247404,
0.0033138732,
0.023068534,
-0.0022646799,
-0.02646984,
-0.63856775,
-0.013893237,
0.008688416,
-0.007172915,
-0.006747752,
0.019941527,
0.006641461,
0.023178253,
-0.0017272256,
0.012460026,
0.00062274415,
0.02630526,
0.0021909622,
-0.02535893,
-0.013749231,
-0.025605798,
0.00073074934,
-0.0011083388,
0.0029881431,
-0.019886667,
-0.03447937,
0.014318401,
-0.005746561,
0.009326161,
0.044244405,
0.008942143,
0.01708882,
-0.013879523,
-0.019543793,
0.020764424,
0.001086052,
0.023260543,
-0.014414405,
0.006761467,
0.051815055,
-0.016471647,
-0.003360161,
0.011541124,
0.016128773,
0.039773334,
-0.037140064,
-0.0067408946,
0.023864001,
0.0014383546,
-0.028389933,
0.016046483,
0.002451546,
0.01928321,
0.008955858,
0.009079292,
0.015004148,
0.006449452,
-0.01928321,
-0.027896194,
0.04117226,
0.0068300418,
0.025742948,
0.0019303783,
0.0028595657,
0.009792469,
-0.0003096577,
0.0035350267,
-0.019296926,
-0.025729233,
0.002972714,
0.012974336,
0.007083768,
0.034259927,
0.0040047634,
0.0038744714,
0.034781095,
0.027032154,
-0.0011837711,
0.011102246,
0.010491932,
0.014880713,
0.018487744,
0.0363446,
-0.01562132,
0.018638607,
0.00792038,
0.0009446167,
-0.020325545,
0.026058393,
0.016361928,
0.0011400547,
0.022327928,
0.018597463,
-0.006854043,
-0.014770994,
0.023877716,
0.0070220507,
-0.027580751,
-0.005191106,
-0.019749518,
0.022492507,
-0.022986244,
0.005372829,
0.01914606,
-0.018570032,
-0.020010103,
-0.008119246,
-0.010464502,
0.001696367,
0.036591467,
0.0011211965,
-0.028417362,
-0.00028201353,
0.025646944,
-0.046356507,
0.019022627,
-0.0068060406,
-0.006977477,
-0.00903129,
0.012631463,
-0.02022954,
0.004306492,
-0.019050056,
-0.0065866015,
-0.035384554,
0.021902764,
0.00694319,
0.01830945,
0.0019475219,
-0.0250572,
0.013557221,
-0.011328543,
-0.006737466,
0.013228063,
-0.021326736,
0.020202111,
-0.0006240299,
0.014578984,
-0.007988954,
0.012124009,
-0.0032418696,
0.022369072,
-0.012741182,
0.024604607,
-0.017952861,
-0.02636012,
-0.009278159,
0.007899807,
-0.0019595225,
-0.008194678,
-0.024673183,
0.007591221,
0.002996715,
0.025482364,
-0.0075637912,
0.00604829,
-0.02161475,
-0.002213249,
0.019365499,
-0.003919045,
-0.007419784,
-0.013296638,
-0.016499076,
-0.0029881431,
0.0049065207,
0.00007698583,
-0.019694658,
0.002353827,
-0.010430214,
-0.014949288,
-0.026881289,
0.021079868,
0.011225681,
-0.009401593,
-0.021463886,
-0.010608508,
-0.035219975,
-0.0009823327,
0.032449555,
-0.01255603,
0.0059111402,
0.00599343,
-0.001514644,
-0.0032092966,
0.006905474,
-0.0013380641,
0.018350594,
-0.029651707,
0.0124943135,
0.024494888,
0.0057259887,
-0.016526507,
0.040184785,
0.0047522276,
-0.00095404574,
-0.045094732,
0.044875294,
-0.014153821,
0.026456125,
-0.011554839,
-0.013543506,
0.008427832,
0.005959143,
-0.0017726563,
0.019543793,
0.035603993,
-0.022012483,
0.005904283,
-0.034753665,
0.014620129,
-0.032284975,
0.024494888,
-0.015305877,
0.003644746,
0.016485361,
0.0006806041,
0.03365647,
-0.005485977,
-0.0000694319,
-0.011829139,
0.015100152,
0.004347637,
-0.014140107,
0.0050813863,
0.00095747446,
0.0030790048,
0.0031887242,
0.031599227,
-0.002484119,
-0.027224163,
0.029432267,
0.029459698,
0.012316019,
-0.005307683,
-0.022533651,
-0.012597175,
0.0045293598,
0.0011100532,
0.025564654,
-0.008695274,
-0.007426642,
-0.0029452841,
-0.019365499,
0.011959431,
0.012048578,
0.0028509938,
-0.022122202,
0.034589086,
0.007255205,
-0.018583748,
-0.015059007,
0.017623702,
0.014249826,
-0.035137683,
0.018419169,
-0.00023422552,
0.014016672,
-0.010608508,
0.009744467,
-0.0010894808,
0.0021429597,
0.0057157027,
0.0052768243,
0.032778714,
0.037112635,
-0.011623414,
0.02871909,
-0.009970764,
-0.0036790334,
0.0061202934,
0.00786552,
0.013591508,
0.005746561,
-0.016361928,
-0.00005614555,
-0.0054311175,
-0.017472837,
0.012206299,
-0.03376619,
0.0010723372,
0.01684195,
0.018816901,
-0.005509978,
0.037359506,
0.022382786,
0.016937954,
-0.028088203,
0.014990433,
0.009065578,
0.0020486696,
-0.005485977,
-0.031736378,
0.010107913,
0.02177933,
0.018885477,
0.01562132,
0.013166346,
0.013324067,
0.011637129,
-0.013282922,
-0.0066208886,
0.020613559,
-0.020325545,
0.014126391,
-0.0038744714,
0.004021907,
0.0065968875,
0.0020881002,
-0.026949864,
0.037880674,
0.02291767,
-0.0025561226,
-0.018762043,
0.009319304,
-0.0101833455,
0.009998194,
-0.014990433,
0.017870571,
0.019694658,
-0.0022269639,
0.022794235,
-0.004930522,
0.015209872,
0.030310024,
-0.0009129009,
-0.014181251,
-0.030913481,
-0.013495504,
-0.013276065,
0.013701228,
0.033080444,
-0.0073100645,
0.0031287214,
0.0011289113,
0.033107873,
0.0050642425,
-0.008578697,
0.020544985,
0.006593459,
-0.0035590278,
0.019187205,
-0.012261159,
-0.03434222,
0.012700037,
0.0035024537,
0.0010071911,
-0.04394268,
0.009394736,
-0.0042379173,
0.02166961,
0.018117439,
0.021381596,
0.03335474,
0.012617747,
0.0036618898,
0.016704801,
0.02044898,
-0.010752515,
-0.006991192,
-0.0052356794,
0.0023658276,
0.00019650941,
0.037030347,
-0.011520552,
-0.03168152,
0.00729635,
-0.029487127,
-0.0010303351,
-0.009730753,
0.008263254,
0.023795426,
0.0148258535,
0.026154397,
0.0027601323,
-0.009223299,
-0.01678709,
0.0474537,
-0.007913522,
-0.009120437,
0.026757853,
-0.0012446311,
0.015854474,
-0.014469265,
-0.0032830145,
0.0051362463,
0.0017880857,
-0.029816287,
-0.0007586078,
-0.025811523,
-0.019927813,
-0.008935286,
0.0016372213,
-0.01673223,
-0.019324355,
-0.0101833455,
-0.0057945633,
-0.023836572,
-0.012453169,
0.009751325,
0.0072620623,
-0.049291506,
0.020819284,
0.025592083,
-0.0028595657,
-0.0011006242,
0.004255061,
-0.005551123,
0.016279638,
0.024728043,
-0.01651279,
-0.019365499,
-0.004025336,
-0.015470455,
0.010567363,
-0.0029692852,
0.016499076,
-0.01900891,
-0.03648175,
-0.016101344,
-0.0056025544,
-0.016238492,
0.032641564,
-0.017267114,
-0.012007433,
-0.01833688,
0.00050359557,
0.003024145,
0.0010466216,
-0.0097718965,
0.013557221,
-0.022629656,
-0.023109678,
-0.024824047,
-0.010423357,
0.017294543,
0.015292161,
-0.001654365,
-0.007618651,
0.010409642,
-0.015004148,
-0.009312446,
-0.014469265,
0.002427545,
0.011616557,
0.028362501,
-0.0077146553,
0.015662465,
0.0068300418,
-0.025948672,
-0.025619514,
-0.010992527,
0.02752589,
-0.0060551474,
-0.024604607,
0.012940049,
-0.0020623845,
-0.00097376097,
-0.017198538,
0.003224726,
0.011486265,
0.028280213,
0.004776229,
-0.0033293024,
-0.022533651,
0.0027978483,
-0.039608754,
-0.0013689228,
-0.0074060694,
-0.0017135107,
-0.016156202,
0.014921858,
-0.0027412742,
-0.022602227,
0.019242065,
-0.021902764,
0.0033910198,
0.0060551474,
-0.033299882,
0.00903129,
0.009559316,
0.013193775,
-0.047563422,
-0.020682134,
0.0033893052,
-0.018748326,
-0.006082577,
-0.025852667,
0.04375067,
0.022451362,
0.0363446,
-0.004138484,
0.0017692277,
-0.00040309076,
0.0146749895,
0.017568842,
0.006449452,
-0.023754282,
-0.031050632,
0.02497491,
-0.0057911347,
0.003140722,
0.021916479,
-0.018611178,
0.012391451,
-0.000036966056,
-0.032531846,
-0.019859238,
-0.03116035,
-0.051677905,
-0.022506222,
0.0026384122,
-0.010190203,
0.0026486984,
-0.049264077,
-0.02272566,
0.0076872255,
0.012247444,
0.0139618125,
-0.034232497,
0.0355217,
-0.0411174,
0.025496079,
0.024865191,
-0.01776085,
0.01315263,
-0.025413789,
0.016265923,
0.023836572,
-0.008811851,
0.0042276313,
0.016060198,
-0.01833688,
-0.018734612,
-0.020490125,
0.0020555272,
-0.022931384,
0.014290971,
0.010238205,
-0.018515173,
0.0064425943,
-0.0107868025,
-0.0181723,
-0.03412278,
-0.021902764,
0.018858047,
-0.01809001,
0.025166921,
-0.006134008,
-0.019077485,
0.0073649245,
-0.0064837392,
-0.003713321,
0.0044059255,
0.014290971,
0.010971954,
-0.0015403596,
-0.0036138876,
-0.019845523,
0.003685891,
-0.0028972817,
0.02305482,
0.008894141,
0.012370879,
-0.015785899,
-0.004992239,
-0.007954667,
-0.039087586,
-0.035603993,
-0.0010046195,
-0.008537552,
0.013701228,
-0.0043579233,
-0.016471647,
-0.025729233,
0.009429024,
-0.0027652753,
-0.00089747156,
0.008400403,
0.013756088,
-0.021409025,
0.007001478,
0.010759373,
-0.004789944,
-0.010896523,
0.0023503983,
0.00035958865,
-0.03681091,
-0.013872665,
-0.0060311463,
0.0011674846,
0.023109678,
0.0061785816,
-0.006387735,
-0.010101056,
-0.007762658,
0.023548556,
-0.016691085,
-0.023767997,
0.0366189,
0.0004757371,
-0.007330637,
0.016252207,
-0.008468977,
0.007748943,
0.021107297,
-0.0068060406,
0.0006664605,
-0.015113867,
-0.012316019,
0.016279638,
-0.0012086293,
-0.05044356,
0.009278159,
-0.029130539,
-0.0006788897,
-0.035384554,
-0.031736378,
0.013138915,
-0.032312404,
0.0107662305,
-0.03146208,
-0.0141126765,
0.041199688,
0.023342833,
0.0058905683,
0.011397118,
0.008283826,
-0.033245023,
0.016389357,
0.014002956,
0.0045225024,
-0.015950479,
0.02926769,
-0.025893813,
-0.030419745,
0.00800267,
0.00059531425,
-0.0241383,
-0.035905723,
-0.006771753,
-0.010011909,
0.013420071,
0.0070906254,
0.013639511,
0.009182154,
0.030748902,
-0.012144582,
-0.020325545,
-0.012473741,
-0.01833688,
0.0044710715,
0.025427504,
-0.000007165522,
0.014894428,
-0.022670802,
0.023191968,
0.02427545,
0.013893237,
0.011671416,
-0.016032768,
0.020106107,
-0.008263254,
0.0061785816,
-0.019022627,
-0.0024241162,
-0.0217519,
0.012713752,
0.02166961,
-0.039663617,
-0.036234878,
0.012076007,
0.0045979344,
0.009717037,
-0.019516364,
-0.01925578,
0.0062505854,
-0.0019492363,
-0.04580791,
-0.016636226,
-0.0058734245,
0.034506798,
0.011582269,
-0.042598613,
-0.012370879,
-0.0064563095,
-0.018981481,
-0.008722704,
-0.016348213,
0.009394736,
-0.007851805,
0.017376833,
0.012398308,
0.013742373,
-0.0052871103,
0.016691085,
-0.036756046,
-0.020915288,
-0.009847329,
-0.041720856,
0.030968342,
0.009634747,
-0.020284401,
-0.02164218,
0.0355217,
-0.00030580038,
-0.0058837105,
-0.0057157027,
-0.01678709,
0.035027966,
-0.042434033,
0.018268304,
0.04103511,
-0.0050676716,
0.010409642,
-0.014551555,
-0.007138628,
0.011040529,
-0.0052013923,
0.0096004605,
-0.025976103,
-0.00088289945,
-0.021299306,
0.031078061,
-0.020860428,
-0.0142635405,
-0.0017589414,
-0.0025475507,
0.011321685,
0.008030099,
0.015223587,
0.0011529124,
0.0013843521,
0.0030858621,
-0.0094907405,
-0.0053899726,
0.0067820395,
0.0041864864,
0.013365212,
0.006476882,
-0.0056265555,
0.0026315546,
-0.0010697655,
-0.021793045,
0.02877395,
0.006720322,
-0.0036996058,
-0.02283538,
0.02893853,
0.0046356507,
-0.00569513,
-0.026030961,
-0.006216298,
-0.009902189,
0.02289024,
-0.01900891,
0.015977908,
-0.01686938,
-0.025921242,
0.0054585473,
-0.019790662,
0.0106359385,
-0.00957303,
-0.0205587,
0.0014006386,
0.02256108,
0.18114696,
-0.010059911,
0.0012086293,
0.033245023,
0.009079292,
0.0048996634,
0.02278052,
0.0013174918,
-0.0054414035,
0.0100736255,
0.006583173,
-0.007796945,
-0.025180636,
-0.0096004605,
-0.005331684,
0.01385895,
-0.02910311,
-0.02064099,
0.014880713,
-0.011342258,
0.010814233,
0.00848955,
0.008194678,
-0.012000575,
0.02760818,
0.004330493,
0.0071180556,
-0.012624605,
0.020010103,
0.047343984,
-0.0060654334,
0.018611178,
0.002744703,
0.025235495,
0.024371454,
0.0049648094,
-0.010025623,
-0.010670226,
0.007515789,
0.0013586365,
-0.0035281691,
-0.0014332115,
-0.021162158,
-0.019790662,
-0.019749518,
-0.0048962347,
-0.0024018295,
0.00069046166,
0.0032555845,
-0.010629081,
-0.0384567,
0.011177679,
0.028389933,
0.036591467,
0.0069569047,
-0.0063328748,
0.019530078,
-0.012130867,
-0.023960005,
0.027676756,
-0.013468074,
0.0066997497,
-0.001533502,
0.016252207,
-0.010512504,
0.018556317,
-0.0010920523,
-0.008585555,
-0.02025697,
-0.0059488565,
0.0000840576,
0.00848955,
-0.027320167,
-0.0031115776,
-0.017966576,
-0.013543506,
0.017801996,
0.030118015,
0.002185819,
0.006212869,
0.004255061,
0.0048208027,
-0.012542316,
0.00423106,
-0.035796,
-0.0070700534,
0.016704801,
0.0035761714,
-0.041803148,
-0.004618507,
0.003517883,
0.008057529,
-0.012837186,
0.0017743708,
0.0038504703,
-0.03831955,
-0.01800772,
0.0058322796,
-0.015772184,
-0.024042295,
-0.0051362463,
0.07076911,
-0.0044402126,
0.026030961,
-0.011787994,
0.000023371656,
0.0052356794,
0.0024035438,
0.015333306,
0.010759373,
0.01442812,
-0.025715519,
0.008105531,
-0.017459122,
-0.0010774803,
0.0012086293,
0.024426313,
-0.013797233,
-0.0036550323,
-0.01939293,
-0.012309161,
-0.004330493,
-0.0018326592,
0.011383403,
-0.011753706,
0.013001766,
0.009799327,
-0.019900382,
0.004450499,
-0.01717111,
-0.0006891759,
-0.027676756,
-0.017788282,
-0.0062608714,
-0.0028012772,
-0.009134152,
-0.009346734,
0.016334496,
0.0015695038,
0.018515173,
-0.000510453,
0.018240875,
0.016691085,
-0.009970764,
0.023191968,
-0.005420831,
0.0067820395,
0.001650079,
0.00157979,
0.0119320005,
-0.023301689,
-0.02671671,
-0.024549749,
0.011774278,
0.034534227,
0.018378023,
-0.019886667,
-0.05225393,
0.018762043,
0.0063740197,
-0.030227734,
0.0084758345,
0.03335474,
-0.0061545805,
0.0033190162,
-0.0073169223,
-0.17500268,
0.037030347,
0.018830616,
-0.036756046,
-0.013502361,
-0.013001766,
0.016224777,
-0.010855378,
0.00041316266,
0.0055202646,
0.029377408,
-0.009182154,
-0.025509793,
0.0048585185,
0.0069809062,
-0.012178869,
-0.015525316,
0.02752589,
0.0061957254,
0.01567618,
0.000088664965,
-0.016704801,
0.010937667,
-0.026661849,
0.00490995,
0.02150503,
-0.0070289085,
0.023754282,
-0.007934094,
-0.00783809,
-0.016183633,
0.011294256,
0.035055395,
0.0076940833,
0.006134008,
-0.020202111,
-0.004090482,
0.017321972,
-0.008866711,
0.023150824,
0.04610964,
0.017129963,
0.0071934876,
0.015333306,
-0.0078038024,
0.036756046,
-0.0012137725,
-0.004879091,
0.005156819,
0.010937667,
-0.0011160534,
-0.016567651,
0.042050015,
0.016060198,
0.009634747,
0.016019054,
0.028746521,
0.023658277,
-0.013920668,
-0.023548556,
0.0018189444,
-0.025976103,
0.034369648,
-0.0071866303,
-0.0014126392,
-0.0107388,
-0.013790376,
-0.0100530535,
0.00015557889,
-0.010910237,
-0.025166921,
0.0026744138,
0.00053702574,
-0.00081903924,
0.0336839,
0.019900382,
0.011061101,
0.007625508,
0.032723855,
0.0024738328,
-0.004618507,
-0.019598654,
-0.032367267,
-0.0004225917,
0.0025029771,
0.0025235496,
0.017870571,
0.02896596,
-0.0044642137,
0.002964142,
0.011767421,
-0.015209872,
-0.001784657,
-0.028746521,
-0.026058393,
-0.005304254,
0.0036036014,
0.019818094,
0.00482766,
-0.017692277,
0.00821525,
-0.011095389,
-0.010745658,
-0.014866998,
0.024673183,
-0.021079868,
-0.0217519,
0.0059248554,
0.012405166,
-0.019461505,
-0.0034493082,
0.00068488996,
-0.006891759,
0.026085822,
-0.012316019,
0.018940337,
-0.006336304,
-0.020929003,
0.02882881,
-0.020435264,
0.0530494,
0.0116097,
0.003332731,
0.013324067,
-0.022849096,
-0.015086438,
-0.1114202,
-0.051184166,
0.018858047,
0.00002633162,
-0.018048866,
0.029541988,
0.0097718965,
0.0053145406,
-0.020147251,
0.026085822,
-0.018158585,
-0.00694319,
0.01098567,
-0.0012643463,
0.016965384,
-0.005437975,
0.020682134,
-0.0181723,
0.0012866331,
0.044244405,
0.014037244,
-0.01562132,
0.011637129,
-0.0014880713,
-0.0066448897,
-0.012850902,
-0.018556317,
-0.0042653475,
0.0060140025,
0.0061820108,
0.032284975,
0.00946331,
0.026798999,
0.009093007,
-0.024549749,
-0.025715519,
-0.044930153,
-0.017898,
0.015484171,
-0.005242537,
0.014194966,
0.0032264404,
-0.006151152,
-0.00069731916,
-0.016773375,
0.0051362463,
-0.0024584036,
-0.02438517,
0.02882881,
-0.017349403,
-0.0053899726,
-0.034643944,
-0.032230116,
-0.012343449,
-0.0013723515,
-0.010615366,
0.02438517,
0.02638755,
0.014688704,
-0.027896194,
0.0042893486,
0.014729849,
-0.03148951,
0.0009917618,
0.013392642,
0.010286207,
0.006953476,
-0.03094091,
0.0031938674,
-0.0006566029,
-0.009449596,
0.005489406,
0.0024892623,
0.000109344524,
-0.009401593,
0.016540222,
-0.026483554,
-0.030803762,
0.013413214,
-0.034067918,
-0.005386544,
-0.023068534,
0.032175258,
-0.015936764,
-0.0077900877,
-0.0084552625,
0.015717324,
0.0035590278,
0.010663368,
-0.007680368,
-0.030282594,
0.018432884,
0.018405454,
-0.018583748,
-0.01700653,
0.017445408,
-0.009799327,
-0.0007718941,
0.025784092,
-0.0021052437,
-0.012754897,
0.003495596,
-0.056670144,
0.014743564,
-0.0019423788,
-0.00088289945,
-0.0045979344,
-0.02205363,
0.009758182,
-0.01717111,
0.0066928924,
-0.016704801,
-0.023589702,
0.016375642,
-0.016224777,
-0.007049481,
-0.008228966,
-0.01933807,
0.022204492,
0.015264732,
0.020147251,
0.011006242,
-0.008811851,
0.0038710427,
-0.0083249705,
0.0007778944,
-0.0057568476,
0.017198538,
-0.036536608,
0.020682134,
-0.008386687,
-0.00542426,
-0.010855378,
-0.03892301,
-0.030419745,
0.013584651,
-0.019872952,
-0.025770377,
0.012521743,
0.012261159,
0.03431479,
0.010491932,
-0.019776948,
-0.02646984,
0.017829426,
-0.012117152,
-0.005880282,
0.002744703,
-0.01592305,
-0.0066380324,
0.0019972385,
-0.0033481605,
0.010725086,
0.027484747,
0.019036341,
-0.029761426,
-0.017733421,
-0.00916844,
-0.0007800374,
-0.010485074,
-0.04317464,
0.0061957254,
0.032339837,
-0.0113696875,
-0.0045979344,
-0.026908718,
0.015991624,
-0.025153205,
-0.0142635405,
0.0068163266,
0.012370879,
-0.018748326,
-0.02636012,
0.008249538,
0.02438517,
0.01706139,
0.019626083,
0.0073237796,
-0.01451041,
0.0056539853,
-0.0027927053,
0.023425123,
0.0017512268,
-0.002269823,
-0.024673183,
0.01144512,
0.0067683244,
0.007227775,
-0.006216298,
-0.01084852,
0.00602086,
0.02275309,
0.0047693714,
0.011760564,
-0.00360703,
0.009723894,
0.011266826,
0.023425123,
-0.004001335,
-0.005681415,
0.010011909,
0.011177679,
0.0068334704,
0.0023692565,
-0.010642796,
-0.030392313,
-0.021134727,
-0.017363118,
-0.0107662305,
-0.025742948,
0.0062094405,
-0.012919476,
0.02438517,
0.0025784094,
-0.0049545234,
0.007762658,
0.0052185357,
0.0024704041,
0.004296206,
-0.0023366835,
-0.019859238,
0.028362501,
-0.008667844,
0.000027938839,
0.0003675176,
-0.004255061,
0.003303587,
0.009586745,
0.0152784465,
-0.01931064,
0.029706568,
-0.020791853,
0.026017247,
-0.022039913,
-0.035302263,
-0.020064961,
0.015155012,
-0.017363118,
-0.027951054,
0.00729635,
-0.018405454,
0.08174106,
0.007831233,
-0.0059488565,
-0.009579888,
0.0026212684,
0.03351932,
-0.008414118,
0.020627275,
-0.018871762,
0.0032607277,
0.009360448,
-0.012960621,
0.00490995,
-0.03842927,
-0.022670802,
0.0110679595,
0.006737466,
0.0059762863,
-0.011712561,
-0.015292161,
0.014565269,
-0.018871762,
-0.011109103,
-0.017555127,
-0.02638755,
-0.011273683,
0.04128198,
0.021628466,
0.0002569409,
-0.04032193,
-0.013714943,
0.014222396,
-0.024714326,
-0.013084056,
0.028636802,
-0.035027966,
0.00007736085,
-0.020284401,
-0.009593602,
0.004333922,
-0.005540837,
0.016471647,
-0.016060198,
-0.0069877636,
0.0006583173,
-0.018775757,
-0.013982384,
-0.0042344886,
-0.018240875
] |
BACKGROUND To compare the clinical results and the cost-effectiveness of using the aromatase inhibitor, letrozole, in conjunction with FSH and FSH alone for controlled ovarian stimulation (COS) in patients undergoing intrauterine insemination (IUI) for a variety of indications. METHODS Four hundred and thirty-two consecutive patients who underwent 872 IUI cycles were included. The study population was composed of two groups. Group I included 308 patients who underwent 589 IUI cycles with letrozole and FSH for the following indications: anovulation (143 cycles), male factor infertility (147 cycles), unexplained infertility ( | [
-0.038809195,
-0.0065898653,
-0.00088594866,
-0.01759952,
-0.0023293481,
0.0033911592,
0.000012747695,
0.009894752,
-0.034535404,
-0.030792521,
-0.001829965,
0.019285144,
0.0040050186,
0.01664389,
-0.0134850005,
0.031004883,
0.030553615,
-0.0012542644,
0.010863654,
0.0050601936,
-0.023094391,
-0.013491637,
-0.025310922,
0.01604662,
-0.0070875892,
-0.029810347,
0.032358695,
-0.043773163,
0.0056441897,
-0.01343191,
-0.0103991125,
0.028854717,
-0.0027889132,
-0.0128810955,
-0.036393575,
-0.03063325,
0.011328197,
-0.018077334,
0.007930402,
-0.014998082,
0.022895303,
0.0077578574,
0.021899853,
0.019855868,
-0.021860035,
0.007857402,
0.0039784736,
0.00089009636,
-0.010910109,
0.011533923,
-0.0056574624,
0.014798992,
-0.027341636,
0.021209676,
-0.0053289644,
-0.0022015988,
0.0041443813,
0.02454111,
0.012920913,
-0.0033745684,
-0.008580761,
-0.0035172491,
-0.028509628,
0.03761466,
-0.019006418,
0.010591566,
-0.01736061,
0.004114518,
0.008534307,
0.0018150334,
0.039817914,
0.022510394,
-0.026094008,
0.0082356725,
0.03299578,
-0.014307904,
-0.040216096,
-0.015382988,
0.03153579,
0.00897894,
0.028005268,
0.00079552876,
-0.019032964,
-0.0033629548,
-0.0033928182,
0.023704933,
0.021952944,
0.03772084,
-0.0139097255,
0.0017470111,
0.0011688217,
0.016856251,
0.0029067078,
0.010578293,
-0.012443099,
0.015077718,
0.0038391107,
0.026439097,
-0.0031489334,
-0.022324579,
0.012005102,
-0.0070809526,
-0.023612024,
-0.014905173,
-0.029943073,
-0.015183899,
0.013763727,
-0.004861104,
0.017519884,
-0.006171777,
0.008633851,
0.047808044,
0.008859486,
-0.018435694,
0.026797457,
-0.019032964,
0.0025417104,
0.0026246642,
-0.009324029,
0.013066913,
0.0022762576,
0.006566638,
0.023054574,
-0.025656011,
0.01891351,
-0.022908574,
-0.0094833,
-0.0013596159,
-0.008965667,
-0.0043600616,
0.0075985854,
0.011553832,
0.014493722,
0.008209127,
-0.026319642,
0.0031273654,
-0.029013988,
-0.03012889,
-0.024010204,
-0.032624144,
-0.012735097,
0.014706084,
-0.0059793238,
-0.004094609,
-0.036234304,
0.012197555,
0.028350357,
0.0043600616,
-0.010246477,
0.009841662,
-0.01694916,
-0.023930568,
-0.0027889132,
-0.008043219,
0.026943456,
-0.019696595,
0.02464729,
0.015674986,
-0.0044098343,
-0.024594199,
0.019298417,
-0.017997699,
0.008189218,
0.005690644,
0.028828172,
0.005959415,
0.028456537,
-0.009629299,
-0.005803461,
-0.008414853,
0.013398728,
0.024302201,
-0.009290847,
0.019165691,
-0.008414853,
0.002100395,
-0.0029647758,
-0.0037329297,
-0.017002251,
-0.022802394,
-0.01880733,
0.012336917,
0.02776636,
0.00623814,
-0.028137993,
0.022868756,
-0.019683324,
-0.021607855,
0.0053156917,
-0.011122472,
-0.020280592,
0.03214633,
0.0010900154,
-0.0032451602,
-0.63029104,
-0.0051464657,
0.0036665665,
-0.016192619,
0.028031813,
0.017480066,
0.0102398405,
-0.014599903,
0.0034641586,
-0.007399496,
-0.029146714,
0.016856251,
0.0044795154,
0.0056640985,
0.007021226,
-0.025868373,
-0.005693962,
-0.013710636,
0.0043102894,
-0.0036964298,
-0.028960897,
0.0052261013,
0.009874843,
0.005647508,
0.027845996,
0.005053557,
0.026943456,
-0.037508477,
0.0022895301,
-0.00041788074,
0.0009946184,
0.018170243,
-0.0059494604,
0.0070809526,
0.038464107,
-0.0063111396,
-0.007153952,
0.016604071,
0.010113751,
0.04180881,
-0.010943291,
-0.011155653,
0.04085318,
-0.008083037,
-0.011706468,
0.029013988,
0.005594417,
-0.00094152783,
-0.0011605263,
0.00011976482,
0.008162673,
-0.010080569,
0.010166842,
-0.004157654,
0.005418555,
-0.0030659796,
0.011460924,
-0.011195471,
0.010538475,
0.01655098,
0.006234822,
0.00448947,
-0.031748153,
0.010644657,
-0.005796825,
0.020492954,
-0.0059992326,
0.0043036533,
0.015966984,
-0.0048113316,
0.024620745,
0.023492571,
0.00030257468,
-0.005431827,
0.028429992,
0.010744201,
0.0018482149,
0.011009654,
-0.0081825815,
0.01069111,
0.017519884,
-0.002702641,
0.0012974004,
-0.0047715134,
0.009124939,
-0.011885648,
-0.008965667,
-0.000903369,
-0.015011354,
0.0027855951,
0.010014206,
0.026930183,
0.0019079418,
-0.015635168,
-0.016816434,
0.0026130506,
0.0037063845,
0.010677838,
0.0096890265,
-0.052798558,
-0.010896836,
-0.014878628,
0.008494489,
0.01584753,
0.0046321508,
-0.0077844025,
-0.048604403,
-0.00079718785,
0.02504547,
-0.042313173,
-0.010034115,
0.008514398,
-0.015263534,
-0.0068752267,
0.014958263,
-0.019205509,
-0.012356827,
0.004217381,
0.008985576,
-0.012489553,
0.024182748,
-0.014055724,
0.017334066,
0.0017768745,
0.0146529935,
-0.0006275469,
-0.0081294915,
0.0010136978,
0.0029398894,
-0.01247628,
0.014613175,
0.00060141645,
0.009589481,
-0.026200188,
0.026080735,
-0.00066363194,
0.017891517,
-0.010093842,
0.031217245,
-0.027182365,
-0.038517196,
-0.004131109,
0.013405365,
0.0009888116,
-0.0016864546,
-0.048206225,
-0.007240224,
0.017241158,
0.0046089236,
0.0024853016,
0.00052717264,
-0.027102727,
-0.006045687,
0.024474746,
0.0026329597,
0.000051872168,
-0.004555833,
-0.026691277,
0.008932486,
-0.010246477,
0.001651614,
0.01790479,
-0.0009191302,
-0.012250645,
-0.024939287,
-0.03838447,
-0.007996765,
0.00019826004,
-0.0017154885,
-0.045710966,
0.014865356,
-0.017918061,
0.005776916,
0.041968085,
0.01624571,
-0.0012102987,
0.00020645175,
-0.004642105,
-0.0019278508,
-0.0052261013,
0.011036199,
-0.0032053422,
-0.024912743,
0.015475897,
0.0150379,
-0.0018332832,
0.011859103,
-0.003349682,
-0.0068022273,
0.012250645,
-0.011095926,
-0.0037462022,
0.015900621,
0.013292547,
0.0031671834,
0.010618111,
0.030925248,
0.01312664,
-0.014201723,
0.021607855,
0.054948725,
-0.0074924044,
0.034986675,
-0.0053156917,
0.001786829,
-0.02032041,
0.014161905,
0.004287062,
0.03506631,
0.0029465258,
0.012164373,
0.01280146,
-0.0219264,
-0.0040050186,
0.0035570671,
0.013790271,
0.01574135,
-0.015648441,
0.008965667,
0.008242308,
-0.010246477,
0.00096724357,
0.015382988,
0.005342237,
-0.008321945,
0.00036603448,
0.0325976,
-0.00191126,
0.022590032,
0.021501675,
-0.0063974117,
0.024182748,
-0.008753305,
0.011932102,
0.016059892,
0.008010037,
0.0140159065,
-0.011454287,
0.029332532,
-0.02610728,
0.015117535,
-0.0006528479,
0.049613122,
-0.010153568,
0.008156036,
-0.0047516045,
0.017997699,
0.022205124,
0.007359678,
0.013027095,
0.021899853,
0.0026561867,
-0.029996164,
-0.009211211,
0.009635936,
-0.013027095,
-0.0071141343,
0.026067462,
0.027792905,
0.02927944,
0.035889216,
0.0037130206,
0.0017121704,
-0.008846214,
-0.005903006,
0.033367414,
0.01126847,
0.021660946,
0.0068287724,
-0.020678772,
-0.010704383,
0.0015736372,
0.0030079118,
0.0008241479,
0.021475129,
0.009470028,
0.024434928,
0.021063678,
0.024474746,
0.015608623,
-0.013644272,
-0.042631716,
0.018993147,
0.0016781592,
0.010883564,
0.0014641379,
-0.018926783,
0.0071937703,
0.02560292,
0.016896069,
0.018289696,
-0.01056502,
0.022444032,
0.011865739,
-0.00027022263,
-0.023532389,
0.008514398,
-0.03732266,
0.005604372,
0.003178797,
0.0033231368,
-0.015130808,
-0.014254814,
-0.0050004665,
0.024780016,
-0.0029166623,
-0.007439314,
-0.03164197,
0.000987982,
-0.014719356,
0.024103113,
-0.016776616,
-0.024780016,
0.0047018323,
0.020665498,
0.013776999,
-0.029438712,
0.0015404556,
0.007963583,
-0.004834559,
0.013279275,
-0.017811881,
0.00066943874,
-0.015422806,
0.01815697,
0.022828938,
0.01599353,
0.010803928,
0.022125488,
0.0081825815,
-0.006706001,
-0.025417103,
-0.00050975225,
0.012456371,
-0.010498657,
0.015011354,
0.0040382002,
-0.005239374,
-0.0142282685,
0.011182198,
0.0012650484,
-0.019324962,
0.0031323428,
-0.008872759,
0.0130403675,
0.017188067,
0.011454287,
0.026439097,
0.017918061,
-0.0082356725,
0.004721741,
0.023479298,
0.010233205,
-0.0018880329,
-0.01856842,
0.0051166024,
0.0037760658,
0.027845996,
-0.0070875892,
-0.016006803,
-0.00073704624,
-0.014268086,
-0.0178517,
-0.0018316242,
-0.0014002634,
0.031084519,
0.007605222,
0.028058358,
0.0024222566,
-0.03469468,
0.0035437946,
0.016723525,
-0.009914661,
0.000701376,
0.025841827,
0.0050668297,
-0.016988978,
-0.0046586962,
-0.014321177,
-0.005050239,
-0.03665903,
-0.020546045,
-0.014666266,
-0.014546812,
0.005561236,
-0.0203735,
0.019391324,
-0.010551748,
-0.013319093,
-0.03522558,
-0.017042069,
-0.014878628,
-0.01529008,
-0.007565404,
-0.012708551,
-0.02464729,
-0.025523284,
0.022284761,
0.022191852,
0.019603686,
-0.008613942,
0.0107176555,
-0.014679538,
0.030420888,
-0.018395877,
-0.022244943,
-0.00008715354,
-0.020121321,
0.000011671886,
-0.010286295,
-0.018356059,
0.0032285694,
-0.021992762,
0.015197171,
0.029651076,
-0.015462624,
0.023227118,
-0.018488785,
-0.008156036,
0.005299101,
0.0076981303,
-0.0028287312,
0.0006408196,
-0.024275657,
-0.011832558,
-0.032889597,
-0.021767128,
-0.019563869,
-0.007718039,
0.028005268,
0.006360912,
0.0016234096,
-0.020546045,
-0.001518058,
-0.0041476996,
-0.009085122,
-0.009071848,
0.004243926,
0.013325729,
0.033632867,
-0.02273603,
0.029067079,
0.02408984,
-0.009184666,
-0.0049772393,
-0.0032999099,
0.034535404,
-0.0075720404,
-0.020546045,
0.016829707,
0.014188451,
-0.01368409,
-0.026147097,
0.014506994,
0.0068088635,
0.043534257,
-0.00058316655,
-0.023904022,
-0.03185433,
-0.014745901,
-0.052851647,
-0.0016582503,
0.000030667055,
-0.012058192,
-0.018794056,
0.0065965015,
-0.022696212,
-0.026094008,
0.029332532,
-0.026651459,
0.008773214,
0.012217464,
-0.024713654,
-0.0006088823,
-0.0075521315,
0.0000033991694,
-0.026731094,
-0.017002251,
-0.010153568,
-0.023718206,
-0.014998082,
-0.02641255,
0.010100478,
0.013604455,
0.036579393,
-0.019072782,
-0.017280975,
-0.003862338,
-0.0082356725,
0.028429992,
-0.013803544,
0.015024627,
-0.022205124,
0.04130445,
0.046321508,
0.00582337,
0.029836891,
-0.019855868,
0.01655098,
0.013989361,
-0.030022709,
-0.027341636,
-0.009012122,
-0.028429992,
-0.026213462,
-0.0029830255,
0.024607472,
-0.010797292,
-0.023598751,
-0.012894369,
0.00299298,
0.0074525867,
0.029757256,
-0.011766194,
0.009536391,
-0.02278912,
-0.009715571,
-0.0010228227,
-0.023638569,
-0.014825538,
-0.010054024,
-0.0039021557,
0.002802186,
0.014732629,
-0.0054384638,
0.0026860503,
0.024886198,
-0.029836891,
-0.0070079532,
0.024182748,
-0.010671201,
0.0082356725,
-0.0009805162,
-0.02298821,
-0.010405749,
-0.0022828938,
0.0035437946,
-0.005368782,
-0.0004927467,
0.015966984,
0.005680689,
0.008036583,
-0.0079171285,
0.012628916,
0.022006035,
-0.018940056,
0.013976089,
-0.008408217,
0.021952944,
0.011733012,
0.027288545,
-0.008414853,
-0.028297266,
-0.00060266076,
0.016909342,
0.03278342,
0.043295346,
-0.007538859,
-0.025510011,
0.009655844,
-0.004934103,
-0.041835357,
-0.041065544,
-0.00075322227,
0.025430376,
0.0024371883,
-0.020944225,
-0.011620196,
-0.029943073,
0.033048872,
-0.02383766,
0.020001866,
0.0010195045,
0.019046236,
0.002971412,
0.02962453,
-0.017280975,
0.015064445,
-0.022457305,
0.020652225,
0.002284553,
-0.024355292,
-0.028456537,
0.002057259,
0.0064339116,
0.020492954,
-0.0027988676,
0.009330665,
-0.016763343,
0.010027478,
-0.0093704825,
-0.010644657,
-0.016935887,
0.03461504,
-0.0022264852,
0.019842595,
0.03063325,
0.004827922,
-0.016059892,
-0.02113004,
-0.0048544677,
-0.0013820136,
-0.025656011,
0.0010684474,
0.02641255,
0.0119586475,
-0.028907808,
-0.0028818217,
-0.011500741,
0.0073729507,
-0.0022115535,
-0.013644272,
0.02545692,
-0.03697757,
0.01775879,
0.010279658,
0.034933586,
0.01775879,
0.026678003,
-0.0142813595,
0.0054716454,
0.025496738,
-0.026970001,
0.0028967534,
0.016524436,
-0.0064272755,
-0.016378436,
-0.0025184832,
-0.029704165,
-0.026930183,
0.004924149,
-0.01209801,
-0.022603303,
-0.013816817,
0.014958263,
-0.0046951957,
0.015130808,
-0.024594199,
0.04310953,
0.0034807494,
0.02046641,
-0.007412769,
-0.0040216097,
-0.0070942254,
-0.008832941,
0.00018965357,
0.019019691,
-0.018342787,
0.006772364,
-0.020585863,
0.030553615,
0.010352658,
-0.025005652,
0.0117993755,
-0.0077379486,
0.00079843216,
-0.015210444,
-0.021740582,
-0.017626064,
-0.028934352,
-0.020346954,
-0.007870675,
0.010916745,
-0.02168749,
-0.018648058,
0.00827549,
0.014931719,
0.007226952,
-0.011991829,
-0.0015661714,
-0.015701532,
0.016166074,
-0.036101576,
0.002143531,
-0.016564254,
0.02827072,
0.010306204,
-0.010279658,
-0.016471345,
-0.005667417,
-0.03185433,
-0.016577525,
0.000038158836,
0.011640104,
-0.0137504535,
-0.002121963,
0.019470962,
0.01383009,
0.015913894,
-0.005053557,
-0.032225966,
-0.026465641,
0.007890584,
-0.033420503,
0.030978339,
-0.00582337,
-0.054152366,
-0.02082477,
-0.0067259097,
-0.008069764,
0.0038756104,
0.024740199,
-0.017825155,
0.018289696,
-0.009954479,
-0.0068088635,
-0.020041684,
0.014321177,
0.029359076,
-0.016524436,
0.0006379162,
-0.007359678,
-0.0049573304,
-0.011786103,
0.019139145,
-0.023373116,
0.0029797074,
-0.012011738,
-0.0137504535,
0.005674053,
-0.010956563,
-0.0138566345,
0.0015412852,
0.011474196,
0.00086106244,
0.00230778,
0.0020904406,
0.007890584,
-0.025018923,
0.011832558,
0.013617727,
0.009549663,
0.0035172491,
0.018886965,
-0.013604455,
-0.022165306,
0.00085525564,
-0.00094318687,
0.010412385,
0.007412769,
-0.0017967834,
-0.021037132,
0.043428075,
0.0077644936,
-0.0047449684,
-0.016564254,
0.009974388,
-0.007605222,
-0.021262767,
-0.01664389,
0.011188834,
-0.038012836,
0.006735864,
-0.001505615,
-0.029969618,
0.02927944,
-0.0041709268,
-0.0095828455,
0.010823837,
0.008494489,
0.19802777,
0.015144081,
0.010153568,
0.034376133,
0.011109198,
0.02827072,
0.04018955,
-0.0012069806,
-0.030394342,
0.019470962,
0.019656777,
-0.0047283773,
-0.0017204658,
-0.0033015688,
0.03012889,
-0.021395493,
-0.018740965,
-0.021568038,
-0.0020025093,
0.0063741845,
0.018621512,
0.0032882963,
0.02358548,
-0.012084737,
0.0034542042,
-0.0018631467,
-0.021594584,
-0.009735481,
0.014002634,
0.008613942,
-0.0004516845,
0.004612242,
-0.0023824386,
-0.01036593,
0.0042107445,
-0.018621512,
-0.017918061,
-0.007120771,
-0.010989745,
-0.009197938,
-0.022510394,
0.022802394,
-0.009728844,
-0.016577525,
0.0012501166,
0.017918061,
0.002284553,
-0.017174795,
-0.0031240473,
0.00573378,
-0.04300335,
-0.0039187465,
0.008972304,
0.01568826,
-0.009974388,
0.0013065253,
0.065779194,
0.008952395,
0.009523118,
-0.0022911893,
0.004738332,
-0.00897894,
0.0011978557,
-0.0004433891,
-0.028536173,
0.015940439,
-0.0015205466,
0.020108048,
0.008686942,
0.027819451,
0.00448947,
-0.004758241,
-0.007850766,
0.009337301,
0.005757007,
-0.015714804,
0.013398728,
0.025058743,
0.0020555998,
0.015051172,
0.0057404162,
-0.0016706934,
-0.007021226,
0.022842212,
-0.025005652,
-0.013206275,
0.013723908,
0.008361762,
0.0011729695,
0.01413536,
-0.014414086,
-0.0027358227,
-0.0055711903,
-0.023426207,
0.035384856,
-0.0081494,
0.02001514,
0.0037760658,
-0.023399662,
0.0042737895,
0.0009954479,
0.06848682,
0.014002634,
0.010790655,
-0.0022414168,
0.009343938,
-0.0003108701,
0.013949543,
-0.0013206275,
-0.0079171285,
0.03642012,
-0.029491803,
-0.019311689,
-0.01886042,
0.0081494,
0.007996765,
-0.0025500057,
-0.016112983,
0.020506227,
-0.01655098,
-0.0051365113,
-0.022775847,
-0.01759952,
0.030447433,
-0.0018731011,
-0.018581694,
-0.008368399,
-0.016511163,
-0.015887348,
-0.01639171,
0.0009100053,
-0.012993913,
-0.0011887307,
0.006208277,
0.017984426,
-0.020798225,
0.0059760055,
-0.002846981,
-0.04255208,
-0.005800143,
0.028429992,
-0.00080175034,
0.00191126,
0.019590415,
0.003510613,
-0.015515715,
0.0032866371,
-0.0044197887,
-0.010949926,
-0.017559702,
0.005126557,
-0.008089674,
0.013697363,
-0.022722756,
0.02610728,
-0.01559535,
-0.013776999,
-0.02419602,
-0.00046703097,
0.026890365,
-0.031270336,
-0.0008291252,
0.021939673,
0.00021796161,
-0.01745352,
-0.011149016,
-0.16681053,
0.00897894,
0.016909342,
-0.016829707,
0.02509856,
0.015701532,
0.008819669,
-0.0019875776,
-0.0015139104,
-0.015807712,
0.022364397,
0.039605554,
-0.01967005,
-0.03103143,
-0.01725443,
0.032916144,
-0.03113761,
0.014613175,
0.0595676,
0.005189602,
0.027978722,
-0.030819068,
0.010146933,
-0.030049253,
0.021116769,
0.010943291,
0.010087205,
-0.0036665665,
0.011739649,
0.0040216097,
-0.02450129,
0.0063045034,
0.025390558,
-0.011122472,
0.016272254,
0.004423107,
0.014944991,
-0.0030460705,
-0.008229036,
0.02248385,
0.014347723,
0.015980257,
0.004044837,
0.0056010536,
-0.0028818217,
0.017931335,
0.007923765,
-0.018103879,
0.01664389,
0.01568826,
0.026757639,
0.012516098,
0.004044837,
0.0065367743,
0.0061618225,
0.029544894,
0.014440631,
0.0116931945,
0.007996765,
-0.023771295,
-0.0028834809,
-0.0141220875,
0.029996164,
-0.0003067224,
0.005634235,
-0.009801843,
-0.0061385953,
0.0057404162,
-0.013976089,
0.027341636,
-0.021368949,
0.014785719,
0.009463391,
0.0012592416,
0.031562336,
0.014679538,
0.025443649,
0.022868756,
0.012031647,
0.013531455,
-0.022377668,
0.0064670932,
-0.036632482,
0.00048113315,
-0.003825838,
0.014666266,
0.008361762,
0.007817584,
-0.009735481,
0.008740033,
0.027978722,
-0.012821369,
-0.021806946,
-0.0016723524,
-0.015157353,
0.02424911,
0.005418555,
-0.011613559,
-0.0061983224,
-0.035995398,
0.019975321,
-0.022523668,
-0.019802777,
-0.002203258,
0.039446283,
-0.005342237,
-0.029146714,
0.006165141,
0.01866133,
-0.0178517,
-0.0300758,
0.0018249878,
0.00050436024,
0.02706291,
-0.01599353,
0.035331763,
0.011122472,
0.006901772,
0.015436078,
-0.020147866,
0.061585043,
0.010180114,
-0.018767511,
0.0001587532,
-0.0005781893,
-0.01300055,
-0.11265816,
-0.00059851306,
0.0231873,
0.03158888,
-0.023970386,
0.03469468,
-0.0053721005,
0.032571055,
-0.019324962,
0.027447816,
-0.013073549,
-0.037667748,
-0.009463391,
-0.0062016402,
0.013027095,
0.00394861,
-0.000026700816,
-0.024448201,
-0.009974388,
0.030447433,
0.027713269,
-0.0140159065,
0.0137504535,
-0.007631767,
-0.0077445847,
-0.019723142,
-0.011991829,
0.014958263,
0.01745352,
0.015130808,
0.005295783,
0.011912193,
0.020479681,
-0.01609971,
-0.027169092,
-0.025788737,
-0.016882796,
-0.01880733,
0.015502442,
-0.015555533,
0.01076411,
-0.00079635833,
0.013060276,
-0.007134043,
0.022842212,
-0.0054384638,
-0.021183131,
-0.033685956,
-0.010578293,
-0.011301652,
-0.038145564,
-0.033685956,
-0.007883947,
0.009503209,
0.01640498,
-0.028111449,
0.013193003,
0.008335217,
-0.031456154,
-0.008461307,
-0.0048876493,
-0.004492788,
-0.029810347,
0.015754621,
0.009602754,
-0.007923765,
-0.0051166024,
-0.0297838,
-0.020904405,
0.024368564,
-0.023519116,
0.0024836424,
-0.025496738,
-0.0016250687,
-0.016842978,
-0.008521034,
-0.028137993,
-0.0049440577,
0.025868373,
-0.036791753,
-0.017732246,
-0.023983657,
0.026545277,
-0.0052460106,
-0.009304119,
0.020254046,
0.028881261,
-0.025576375,
-0.00706768,
-0.031004883,
-0.004967285,
0.012370099,
-0.014414086,
-0.04146372,
-0.019962048,
-0.0065998198,
-0.033659413,
-0.016312072,
0.033579774,
0.017679155,
-0.019603686,
-0.004671969,
-0.06694719,
0.03687139,
0.022006035,
-0.026266553,
0.00004689493,
-0.011514014,
0.013558,
0.018621512,
0.0203735,
0.01574135,
-0.016365163,
0.005401964,
-0.01871442,
-0.013392093,
-0.011872375,
-0.0058067795,
0.02520474,
-0.009164757,
0.010359295,
0.0006175925,
-0.00072792126,
-0.005776916,
-0.0025300968,
0.026279824,
-0.0016632276,
-0.016166074,
-0.00706768,
0.018727694,
-0.010790655,
-0.00872676,
0.0021153267,
-0.027288545,
-0.034774315,
0.00029884177,
-0.017944608,
-0.01795788,
0.007127407,
0.030606704,
0.019165691,
0.0019826004,
-0.024129657,
-0.011600286,
0.021329131,
-0.005796825,
-0.022059126,
0.018117152,
0.0031721606,
0.011115835,
0.0036068396,
-0.007731312,
0.0040481547,
0.0064471844,
0.005508145,
-0.027607089,
-0.017002251,
0.014400813,
-0.005883097,
-0.011613559,
-0.037694294,
-0.008122855,
0.033075415,
0.0014284677,
-0.010584929,
0.0041244724,
-0.00065823994,
-0.010206659,
-0.036234304,
-0.019829322,
0.02454111,
-0.0012609006,
-0.0584527,
0.013020459,
-0.0311907,
0.0020705317,
0.007651676,
0.006686092,
-0.017546428,
0.019550597,
0.018940056,
0.018648058,
-0.008215764,
-0.024408383,
-0.015701532,
0.012383372,
-0.0002252201,
0.0059726876,
-0.005611008,
0.022457305,
0.00286689,
0.001143106,
-0.0012119578,
0.014161905,
0.016564254,
0.0047681956,
0.014307904,
0.015874077,
0.0056209625,
-0.0085011255,
-0.01795788,
0.0063045034,
0.011739649,
0.0050369664,
0.0010642997,
-0.028137993,
-0.020851316,
0.0007026203,
-0.030261615,
-0.03551758,
-0.026200188,
0.024554381,
0.008029946,
0.011752921,
0.013478365,
0.006948226,
-0.004078018,
0.029757256,
0.009171394,
-0.027394727,
-0.0029996163,
0.016471345,
0.00751895,
0.031349972,
0.019590415,
0.0092643015,
0.01126847,
-0.0076981303,
0.012887732,
-0.022550212,
0.034323044,
0.017533155,
0.031270336,
0.0024239155,
-0.048763674,
-0.0191126,
0.013378819,
-0.0368183,
-0.0006229845,
-0.010525202,
-0.01736061,
0.09550991,
0.013657545,
-0.024103113,
0.010067296,
-0.022603303,
0.021647673,
-0.01775879,
0.007850766,
-0.023213845,
-0.009078485,
0.026266553,
-0.006108732,
0.027102727,
-0.033924863,
-0.030553615,
-0.001957714,
0.007134043,
-0.0012940823,
-0.0018681239,
-0.035783034,
-0.0069084084,
-0.028536173,
-0.018289696,
-0.0019859185,
-0.01815697,
0.01759952,
0.0054384638,
-0.005090057,
-0.0005620133,
-0.027607089,
-0.00072667695,
-0.006068914,
-0.0143875405,
-0.00910503,
0.01191883,
-0.0006943249,
-0.0038722923,
-0.0016001825,
0.004947376,
-0.006072232,
-0.036951028,
0.020280592,
-0.016683707,
-0.007711403,
-0.016564254,
-0.008706851,
0.011514014,
0.011188834,
-0.02504547
] |
Solitary metastatic brain tumors are the most common intracranial neoplasms encountered by neurosurgeons. Surgical resection of brain metastasis with whole brain radiotherapy (WBR) significantly increases survival in comparison with WBR alone. Stereotactic radiosurgery (SR) seems to provide results that are similar to those of surgical resection. To analyze the economic efficiency of these different treatments, we compared the results of surgical resection and SR as reported in the medical literature between 1974 and 1994. We included studies in which: 1) at least 75% of patients received WBR | [
-0.006626986,
0.015969126,
0.011557839,
-0.014118799,
0.0023598373,
-0.0091443695,
-0.01004942,
-0.003955409,
-0.031428743,
0.0030034292,
-0.002901192,
0.031428743,
0.001376013,
0.027245393,
-0.009694104,
-0.00085812266,
0.032179598,
0.003791159,
-0.01045837,
-0.010411441,
-0.014440595,
-0.018315556,
0.010766758,
0.0103913285,
0.010652788,
0.010465073,
0.018382596,
-0.027701272,
0.009291859,
-0.010257247,
0.0045353123,
0.0059130015,
-0.027486742,
0.00044917356,
-0.0075555015,
0.012684125,
0.009097441,
0.000045357312,
-0.009084033,
0.006519721,
-0.0026497887,
-0.0016299302,
0.012831615,
-0.0001301011,
-0.035209846,
-0.00500795,
-0.0029296842,
-0.030999681,
-0.001207573,
0.007656063,
0.02055472,
0.01981727,
-0.035183027,
0.008306359,
-0.0059968024,
-0.015969126,
-0.014212656,
0.045936376,
0.03706017,
-0.035129394,
0.0016584225,
-0.012596972,
-0.01966978,
0.025073271,
-0.008715308,
-0.005011302,
0.0030587378,
-0.0027939267,
-0.004857108,
0.0035900364,
0.0333327,
0.026119107,
-0.03904458,
-0.0028106868,
0.019173678,
-0.020340187,
-0.018516678,
0.0096136555,
0.016344555,
0.0017682019,
0.022418454,
-0.031241028,
-0.009546614,
0.019482065,
0.05025381,
-0.002095026,
-0.022713434,
-0.00015010861,
-0.0090304,
0.004260445,
0.0027335898,
0.021627372,
-0.008165574,
-0.0005421927,
0.0018352427,
0.03239413,
-0.008158869,
0.016264105,
0.0034358427,
-0.037274703,
0.007180073,
0.008473961,
-0.015298718,
-0.018087616,
-0.011075146,
0.025193945,
-0.011899748,
0.005879481,
0.019026188,
-0.019991577,
-0.01850327,
0.02390676,
0.004277205,
-0.018784842,
0.02866666,
0.009539911,
0.037542865,
-0.012053941,
0.002829123,
-0.0093790125,
0.02623978,
-0.03285001,
0.018396005,
-0.009124258,
0.03049017,
-0.004937557,
-0.04751854,
-0.014373554,
0.00612418,
-0.018892106,
0.0032447763,
-0.0024503423,
0.01791331,
0.025582781,
0.0010986316,
0.00438447,
-0.0036637813,
0.0024905668,
-0.036738377,
-0.042798866,
0.004293965,
0.015982535,
0.0028509113,
-0.025797311,
-0.0359607,
0.030302456,
0.035719354,
0.014655125,
0.009238226,
-0.018047392,
-0.008541002,
-0.03531711,
0.0024369343,
0.00030315027,
0.014306514,
-0.007079512,
0.004944261,
0.040707193,
-0.011490799,
-0.020367004,
0.0015754595,
-0.00014424254,
0.0076761753,
0.0280767,
0.012027125,
0.02119831,
0.010827094,
0.0097410325,
-0.013247268,
-0.012402554,
0.017953536,
0.033466782,
-0.025019638,
0.0057755676,
-0.0059934505,
0.0008949951,
-0.018999372,
0.012523227,
-0.020434046,
-0.021506699,
-0.019549107,
-0.012865135,
0.008641563,
0.0066672107,
0.008239319,
-0.009499686,
0.015459616,
-0.025408475,
0.00069010153,
-0.017524473,
0.00256934,
0.03239413,
-0.0058359043,
-0.017269718,
-0.6268586,
-0.02316931,
0.0044112867,
-0.013334421,
0.037194252,
0.024791699,
0.02083629,
-0.004766603,
-0.009633767,
0.0019877607,
0.009499686,
0.022096658,
0.007180073,
-0.014521044,
0.0038514957,
-0.030114742,
-0.008789053,
0.018798249,
0.004173292,
-0.005862721,
-0.01799376,
0.032447763,
-0.027942618,
0.017806046,
0.002731914,
0.007260522,
0.0053800265,
-0.023826312,
-0.012865135,
0.0090907365,
-0.026427496,
0.043710623,
-0.002894488,
-0.007729808,
0.051219195,
-0.005618022,
-0.021587148,
0.029149354,
0.040036783,
0.019267535,
0.0018603831,
-0.0050481744,
0.017001554,
-0.009097441,
-0.03826691,
0.0387496,
0.016612718,
0.004179996,
-0.0117991865,
-0.029632047,
0.011430462,
0.008152165,
-0.026373863,
0.008473961,
0.012221543,
-0.018261923,
0.021292169,
-0.024094475,
-0.016840657,
-0.0058727767,
0.008654972,
0.012402554,
-0.012670717,
-0.010002492,
-0.010646084,
0.015995942,
-0.0009855002,
-0.002820743,
-0.009345492,
-0.014588085,
0.035880253,
0.020943556,
0.019213902,
0.000054261174,
0.03290364,
0.029042087,
0.00058325526,
0.013864044,
-0.020742433,
0.005323042,
0.019562514,
-0.015821636,
-0.02917617,
0.0031827635,
0.007863889,
-0.027299026,
0.00030315027,
0.00129305,
0.015526657,
0.0073677874,
-0.0061711087,
0.033869028,
-0.022619577,
-0.026266597,
0.010900839,
0.005493996,
0.027674455,
0.010907543,
0.037328336,
-0.017417207,
-0.031267844,
-0.0011707005,
0.036175232,
-0.0016768588,
-0.009338788,
-0.0011782426,
-0.024094475,
0.0013525487,
0.030061109,
-0.0079711545,
-0.01016339,
0.0011832707,
-0.0002178827,
0.0058258483,
0.020085433,
-0.017524473,
-0.0061979247,
-0.0048973328,
-0.026588393,
-0.024335822,
0.031482376,
0.00128467,
0.017014964,
-0.005074991,
0.02866666,
-0.013615993,
0.018114433,
-0.000889129,
0.0030453298,
-0.011450574,
-0.013629401,
-0.021989392,
0.010572339,
-0.017014964,
0.007743216,
0.007944339,
-0.0084404405,
-0.029927026,
-0.015875269,
-0.030919231,
-0.034190822,
0.005470532,
0.022284372,
0.026749292,
-0.01776582,
-0.0028475593,
-0.018396005,
-0.002009549,
-0.018597126,
0.0047163223,
-0.0011044977,
-0.0011748906,
0.012670717,
0.0031257789,
0.030624252,
-0.012670717,
-0.018302146,
-0.021908944,
-0.0043308376,
-0.01666635,
0.0145076355,
0.010766758,
-0.010116462,
0.001292212,
-0.02587776,
-0.0508974,
-0.004179996,
0.017564697,
0.022941373,
-0.049154337,
0.010827094,
0.012449482,
0.013173523,
-0.0035129397,
-0.009412533,
0.00855441,
0.0007416392,
-0.0010030984,
0.017859677,
0.004944261,
-0.027191762,
0.011262859,
0.007582318,
-0.009922043,
0.014467412,
0.015271901,
0.01755129,
-0.022297781,
-0.01681384,
-0.0047699553,
0.007837073,
0.040734008,
-0.005715231,
0.005085047,
0.02106423,
-0.0136226965,
-0.0031978476,
0.0033436615,
0.009130961,
0.013133299,
0.022860924,
0.0060370266,
0.019951351,
0.004934205,
0.022995004,
-0.02392017,
0.029739313,
-0.013602585,
0.0060873074,
-0.008460553,
0.0018771433,
-0.00581244,
0.009425941,
-0.010190207,
-0.00044875455,
0.017444024,
0.016130025,
-0.016009351,
0.009231523,
0.006533129,
-0.011993605,
-0.006613578,
0.017430617,
-0.010384625,
-0.0007609134,
0.022901148,
0.019240718,
0.001855355,
0.009432645,
-0.016062982,
-0.01063938,
0.04145805,
0.03129466,
0.022525718,
0.029497966,
0.008400216,
0.009345492,
-0.0022844162,
0.01462831,
-0.010076237,
0.01052541,
0.016210472,
-0.0034090262,
-0.0146149015,
0.01689429,
0.029202987,
0.043683805,
-0.012550044,
-0.008138757,
0.008333175,
-0.027620822,
0.003620205,
-0.0023866536,
0.018396005,
0.016518861,
-0.007414716,
0.01791331,
0.014869656,
0.015043963,
0.01499033,
0.020635167,
0.01042485,
0.016116615,
-0.016022759,
-0.0030989624,
0.009244931,
0.016518861,
-0.0042101643,
0.032769557,
0.008078421,
-0.007743216,
-0.0293907,
0.0015645653,
-0.032179598,
0.010907543,
0.0051118634,
-0.0023447531,
0.025234168,
-0.0070526954,
0.011899748,
0.0022576,
-0.03649703,
0.021506699,
0.01755129,
-0.0103444,
-0.015727779,
-0.0021821791,
-0.005953226,
0.0022173754,
0.016438412,
0.019187085,
0.004059322,
-0.015875269,
0.03134829,
0.00036662954,
-0.018798249,
-0.0005157954,
0.0048001236,
0.017578106,
-0.027446516,
0.015995942,
0.016760208,
0.00084261945,
-0.014936698,
0.030758334,
-0.008453849,
-0.022190515,
-0.03392266,
-0.015298718,
-0.005219129,
0.0068247565,
-0.034458987,
-0.004357654,
-0.01814125,
0.023638597,
0.002743646,
-0.011209227,
0.0034894752,
0.004756547,
0.024697842,
-0.007917522,
-0.022297781,
-0.0017966942,
-0.014601493,
0.050200175,
0.02925662,
0.0001292631,
0.016036168,
0.023879943,
-0.008661675,
-0.023531333,
-0.016103208,
0.007736512,
-0.029497966,
0.006549889,
0.011933268,
0.0154998405,
0.016827248,
0.016800432,
0.015352351,
0.0014162376,
-0.024550352,
-0.016357962,
-0.015835045,
0.011182411,
-0.013810411,
0.031884618,
0.03392266,
0.018007167,
-0.011262859,
-0.0025861,
0.021828495,
0.010693013,
-0.014212656,
-0.007830369,
0.016143432,
-0.012898656,
0.030463355,
0.009486278,
-0.020232923,
0.012429371,
0.005309634,
-0.0058593685,
-0.00086985476,
0.0037006538,
0.027017456,
0.030382905,
0.007113032,
0.032313682,
-0.03357405,
0.015365759,
-0.007951043,
-0.007334267,
-0.012188023,
0.009566727,
-0.002834151,
-0.01973682,
-0.014065166,
-0.0029967253,
0.011028217,
0.0069856546,
-0.001050865,
-0.0073879,
0.007964451,
0.020527903,
-0.007964451,
0.010257247,
0.0011019837,
-0.019401617,
-0.003885016,
-0.01732335,
0.0023548093,
-0.01791331,
-0.0053297463,
0.0005090913,
-0.0030822023,
-0.030704701,
0.0030872303,
0.022016209,
0.0048705162,
0.03561209,
-0.011001401,
-0.022552535,
0.026749292,
-0.019575922,
0.00077306456,
-0.015043963,
-0.025287801,
0.0007567234,
-0.004112955,
-0.021748045,
-0.017242901,
-0.028693477,
0.016384779,
0.014816023,
0.0036034447,
0.011081849,
0.020165881,
0.009365604,
0.011236044,
0.022552535,
0.010599155,
0.010431553,
-0.0043475977,
-0.00034903132,
0.0077901445,
-0.025609598,
-0.01290536,
0.007113032,
-0.018114433,
0.012952289,
-0.00037521916,
-0.009446053,
0.006228093,
0.025247578,
-0.0039252406,
0.013113187,
0.011088554,
0.015768003,
0.024563761,
0.015687555,
0.013904269,
0.021533515,
0.02390676,
0.027379476,
-0.013287493,
0.018074209,
0.0006846545,
-0.027862169,
-0.014386962,
0.001534397,
-0.004354302,
-0.016237289,
0.0017195974,
0.018020576,
0.036362946,
0.008380104,
-0.02354474,
-0.009573431,
-0.012429371,
-0.013240565,
0.0058526644,
-0.015124411,
-0.023209536,
-0.021721229,
0.035799805,
-0.01499033,
-0.024523536,
-0.011745553,
-0.016947921,
0.0037777508,
0.010304175,
-0.006932022,
0.0019927886,
-0.014212656,
0.010726533,
-0.003620205,
-0.0025592837,
-0.018999372,
-0.025220761,
-0.0030101333,
-0.007334267,
0.035880253,
0.032930456,
0.016585901,
0.015593697,
0.018033983,
0.018020576,
0.013837228,
0.0014137236,
-0.009580134,
0.0017229493,
-0.007005767,
0.02333021,
0.00040999657,
-0.006449328,
0.0006779504,
0.014212656,
0.011390237,
0.025167128,
0.0036067967,
-0.028264415,
-0.00078772975,
-0.023866536,
-0.016076392,
0.0046895063,
0.006201277,
0.015633922,
-0.02756719,
-0.0028157148,
0.0149769215,
-0.0020615056,
-0.000076992204,
0.009915339,
0.009808074,
-0.008346584,
-0.006623634,
0.0020548014,
-0.0037006538,
-0.021104453,
-0.014454003,
-0.018047392,
-0.024322413,
-0.0070526954,
0.010257247,
0.00052627054,
0.019468658,
-0.0046559856,
-0.0127377575,
-0.0064660884,
-0.017819453,
-0.0022190516,
-0.0077633285,
-0.002661521,
-0.012979105,
-0.006462736,
-0.013756779,
-0.0056113177,
-0.0026564929,
0.0045721848,
-0.008152165,
0.01403835,
-0.007977859,
-0.016022759,
0.028559394,
-0.022632984,
-0.00083423936,
0.002252572,
0.029337067,
0.02420174,
-0.01462831,
-0.0083130635,
-0.016492045,
-0.006543185,
-0.0029146,
0.021479882,
0.026950413,
0.00048772205,
-0.017966943,
-0.01777923,
0.00581244,
-0.041028988,
-0.03239413,
0.022565944,
-0.015419391,
-0.01755129,
-0.021077637,
-0.0069789505,
-0.021828495,
0.057976913,
-0.020675393,
-0.008212502,
0.009345492,
-0.0116584,
-0.008876206,
0.031053314,
-0.023115678,
0.018235106,
-0.026722476,
-0.0024503423,
-0.010579043,
-0.005396787,
-0.016867474,
0.024416272,
-0.0032782967,
0.036818825,
-0.0234777,
-0.0023045286,
0.0024872147,
0.0076761753,
-0.0043140776,
-0.013515431,
0.00257772,
0.040412214,
-0.009747737,
-0.0011531023,
0.015754595,
-0.015218269,
0.001531883,
0.011034921,
-0.014467412,
0.022177108,
-0.016062982,
-0.0026246486,
0.024416272,
0.033091355,
-0.03523666,
-0.0068046446,
-0.021412842,
-0.011872931,
-0.02691019,
-0.004106251,
-0.000809937,
-0.046231356,
0.0017263014,
0.012570156,
-0.0043140776,
0.048859358,
-0.00045043058,
0.00036830557,
0.006456032,
0.02837168,
-0.017430617,
-0.007837073,
0.02119831,
0.022203924,
-0.018825065,
-0.0029732608,
-0.017068597,
-0.03912503,
0.010512003,
-0.03370813,
-0.01645182,
-0.022083249,
0.002183855,
-0.0047196746,
0.013502023,
-0.017269718,
0.026360454,
-0.013388054,
0.015486432,
-0.019951351,
-0.030087925,
0.022860924,
0.0027587302,
0.016062982,
0.004773307,
-0.022405045,
-0.021412842,
-0.0051286235,
0.017886493,
0.01630433,
-0.019508881,
0.00628843,
-0.005403491,
0.03478078,
-0.008903023,
0.0013324366,
0.01784627,
0.0020548014,
-0.021251943,
0.016076392,
-0.013850636,
-0.02931025,
0.005071639,
-0.008286247,
-0.03134829,
-0.008634859,
-0.05293544,
0.006777828,
0.00019473267,
-0.020367004,
-0.032662295,
0.003968817,
-0.023155903,
0.018583719,
0.021359209,
-0.00010365141,
-0.011088554,
-0.013039442,
-0.047786705,
0.02917617,
0.017524473,
0.029578416,
0.0027553781,
0.017752413,
-0.0074549406,
0.027285619,
-0.004521904,
0.0024017377,
0.027433109,
0.0042503886,
0.0010977936,
-0.0067241956,
0.011732145,
0.010478482,
-0.05264046,
-0.008199094,
0.012322105,
-0.027969435,
0.0052325367,
0.014132207,
-0.01776582,
0.0025710159,
-0.0002095026,
0.00072906906,
0.023652006,
0.019173678,
-0.0066370424,
-0.024376046,
0.006372231,
0.016867474,
0.01733676,
0.0036269089,
-0.017604923,
0.012375738,
0.020796066,
0.0023313449,
-0.00891643,
-0.009425941,
0.02369223,
-0.03027564,
0.0045990013,
0.017135637,
0.009942155,
0.008252726,
-0.011222635,
-0.013005922,
0.009881819,
-0.01842282,
-0.017497657,
-0.009533206,
-0.01403835,
-0.027366068,
-0.020434046,
0.02398721,
0.022565944,
0.009311971,
0.0062783738,
-0.012878544,
-0.0042503886,
-0.0187178,
0.021828495,
0.006519721,
-0.027728088,
-0.018302146,
0.00007149276,
-0.04167258,
-0.012040533,
-0.022552535,
0.018530086,
-0.03797193,
0.014923289,
-0.021801678,
-0.0180608,
0.00061551866,
0.02515372,
0.015419391,
-0.015674146,
-0.0033369574,
0.18674894,
-0.010646084,
-0.017926719,
0.018463045,
0.015540064,
-0.0076426547,
0.04666042,
-0.008098532,
0.006063843,
0.00091426936,
0.0038313835,
0.021251943,
-0.04043903,
0.004927501,
0.024362639,
-0.0009829862,
-0.026132517,
-0.025475515,
-0.012288584,
0.009184594,
0.015620514,
0.022686617,
-0.013957901,
-0.018999372,
0.012174615,
0.0048034755,
-0.019106638,
-0.0141992485,
0.03252821,
-0.007589022,
-0.015754595,
0.0149769215,
-0.014494228,
0.0014857925,
-0.0065130168,
-0.010612563,
-0.023115678,
-0.015687555,
-0.026896782,
0.01144387,
-0.014373554,
0.0233168,
-0.0036570774,
0.0072068893,
-0.003968817,
0.008212502,
0.0066303383,
0.01579482,
0.0052090725,
0.005490644,
-0.02682974,
0.0110416245,
0.032715924,
0.0072068893,
0.0031710314,
-0.016223881,
0.03408356,
0.002735266,
-0.0052895215,
0.019455248,
-0.03298409,
0.013662921,
-0.031482376,
0.036684744,
-0.00756891,
0.030141558,
-0.0050347666,
0.02193576,
0.032474577,
0.012516523,
0.014373554,
-0.004605705,
-0.041645765,
-0.0027654343,
0.0061744605,
-0.019549107,
0.026065474,
0.011189114,
0.016331147,
0.0132070435,
-0.0028391792,
-0.01681384,
0.007816961,
0.022780474,
-0.023088863,
-0.017671963,
-0.00015953623,
0.013247268,
0.013797003,
0.018918922,
-0.008762237,
0.010900839,
-0.004448159,
-0.013461799,
0.01733676,
-0.004464919,
0.009861706,
0.01725631,
-0.028130332,
0.010364513,
-0.02149329,
0.082326144,
0.026199557,
0.011893043,
0.025636414,
0.012335513,
-0.0029430925,
0.021962576,
0.00030063622,
0.015285309,
0.014708758,
-0.027406292,
0.004820236,
-0.012945585,
0.014279697,
0.004025802,
-0.0112762675,
-0.03671156,
0.013971309,
-0.024429679,
0.013502023,
-0.037462417,
0.0055107563,
0.024818515,
-0.02625319,
-0.0015176368,
-0.01763174,
-0.0005945684,
-0.0004680288,
-0.03405674,
-0.022338005,
-0.014279697,
-0.024697842,
0.013227156,
0.01448082,
0.0073074508,
0.0045420164,
0.003794511,
-0.025582781,
0.01579482,
0.013696441,
0.004773307,
-0.005239241,
0.022364821,
0.00004106251,
-0.02178827,
-0.010585748,
0.01257686,
-0.0039420007,
0.0025291154,
-0.025314618,
-0.034190822,
-0.004917445,
-0.018342372,
0.022860924,
-0.0136763295,
-0.02756719,
-0.047464907,
-0.012643901,
0.031160578,
-0.03896413,
-0.007079512,
0.015942309,
-0.043415643,
-0.010652788,
0.0049073887,
-0.16883563,
0.008004676,
0.039151844,
-0.03531711,
0.01717586,
0.0024000618,
0.024617393,
-0.01579482,
-0.01739039,
0.0021386025,
-0.0064761443,
0.024067659,
-0.0400636,
-0.008111941,
0.0071398485,
-0.014413779,
0.02127876,
0.036872458,
-0.0012754519,
0.0068314606,
-0.0036838937,
-0.024469903,
0.015070779,
-0.025971618,
0.0047766594,
-0.006767772,
-0.0077499202,
0.011584655,
0.004173292,
-0.01469535,
-0.0030939344,
0.004743139,
0.009513094,
-0.0349685,
0.0069856546,
0.009995788,
-0.008601339,
-0.008333175,
-0.023799496,
0.024295596,
0.017792637,
0.024764882,
0.0021486587,
0.005969986,
-0.0051319757,
0.009633767,
0.010532115,
-0.010800278,
-0.005423603,
0.014762391,
-0.0037643427,
-0.0023715694,
-0.044354215,
0.016988147,
0.028425312,
-0.00049526413,
0.025770495,
-0.016089799,
-0.0035699243,
-0.014413779,
-0.029337067,
-0.03738197,
0.02288774,
-0.024523536,
-0.021251943,
-0.027486742,
-0.009747737,
-0.014668534,
-0.0044213426,
0.009499686,
-0.045212336,
0.01004942,
-0.009110849,
-0.033171803,
-0.009070625,
0.018905515,
0.021077637,
-0.0015662414,
-0.009935451,
0.0030587378,
0.01323386,
0.019616148,
-0.0036905978,
-0.021560332,
0.0029363884,
0.004029154,
0.026212964,
0.013146707,
0.0016634506,
-0.021506699,
0.019951351,
-0.017229494,
0.0026782812,
-0.020219514,
0.006999063,
0.026802924,
-0.008105236,
0.003952057,
0.0046392255,
-0.0068716854,
0.00077683566,
0.0021737989,
-0.026212964,
-0.012992513,
0.044649195,
-0.01981727,
-0.009633767,
0.02888119,
0.014413779,
0.003072146,
-0.019750228,
0.015768003,
-0.0055275164,
0.011859523,
0.003222988,
0.022767067,
0.011933268,
-0.002820743,
0.014105391,
-0.0041531795,
0.046150908,
-0.0030118094,
-0.02896164,
-0.018932331,
0.019803861,
0.0020883218,
-0.12517864,
-0.011531023,
-0.0097410325,
0.02040723,
-0.010833798,
0.018892106,
-0.010250543,
0.016572494,
-0.023517923,
0.043978784,
-0.01659931,
-0.016143432,
-0.011946676,
-0.005738695,
0.027540373,
-0.016089799,
0.019160269,
-0.010646084,
-0.0046157613,
0.035504825,
0.013998126,
-0.013247268,
-0.004511848,
-0.024912372,
-0.006429216,
0.010894135,
-0.0145612685,
-0.007930931,
0.010257247,
-0.009888522,
-0.0136763295,
-0.01763174,
0.022472087,
0.0049543176,
0.019683188,
0.010257247,
-0.035799805,
-0.029444333,
0.031267844,
-0.016170248,
-0.0037676948,
0.013696441,
0.014065166,
0.02106423,
-0.023665413,
-0.012710942,
-0.050119724,
0.0026732532,
0.005148736,
-0.0017263014,
-0.013770186,
-0.034485802,
-0.0032766205,
-0.016237289,
0.01499033,
-0.0014983626,
0.023812903,
0.019455248,
-0.0062783738,
0.002911248,
0.015540064,
0.0028676717,
-0.023893353,
0.027540373,
0.0048269397,
-0.016947921,
-0.016237289,
-0.033761762,
-0.006885093,
-0.0074549406,
-0.0134416865,
0.008178981,
-0.034110375,
-0.005624726,
-0.035290293,
-0.0070728078,
-0.022270964,
-0.014735575,
0.009077328,
-0.026521353,
-0.020125657,
-0.008004676,
0.015513249,
-0.017873086,
0.00079401484,
0.016143432,
-0.020729026,
-0.010036012,
0.016076392,
-0.021171495,
0.019213902,
0.041645765,
-0.017376984,
-0.029202987,
0.020956963,
-0.009586839,
-0.028103517,
0.0017346815,
0.024671026,
0.018878698,
-0.02661521,
-0.012255064,
-0.056314297,
0.015969126,
0.018972555,
-0.01440037,
0.0009754441,
0.007582318,
0.027781721,
0.013428278,
0.0008246022,
0.0076426547,
-0.024014026,
0.01180589,
-0.014601493,
0.0019408321,
-0.030651068,
-0.02055472,
0.010800278,
-0.025931394,
0.011169002,
0.025086679,
0.011048329,
0.004106251,
0.028827557,
0.007656063,
-0.028908007,
-0.012047238,
-0.0048939805,
0.024630802,
-0.024671026,
-0.012107574,
-0.0069052055,
-0.019857494,
-0.025676638,
-0.012777982,
-0.013321013,
-0.012027125,
0.0024771588,
0.02390676,
0.0012402554,
0.038883682,
-0.036684744,
-0.022565944,
0.02055472,
0.000483113,
-0.005718583,
0.024094475,
-0.017658556,
0.022860924,
-0.00876894,
0.0031944956,
-0.0007185939,
-0.004438103,
0.006861629,
-0.031026497,
-0.042503886,
0.010793574,
-0.014118799,
-0.002746998,
-0.032581843,
-0.016773617,
0.018342372,
0.014722167,
0.00075462833,
-0.006315246,
0.021158086,
-0.0026179445,
0.0031777355,
0.012657309,
0.0043945266,
-0.024268782,
-0.039983153,
0.0034894752,
0.02858621,
0.018114433,
0.004904037,
-0.012891952,
-0.01783286,
0.009620359,
-0.018074209,
0.028291231,
0.022244148,
-0.007180073,
-0.013502023,
0.008272839,
-0.00661693,
0.016130025,
-0.01835578,
0.0274197,
-0.010223727,
0.0032850008,
0.012798095,
0.009104145,
-0.0018737912,
0.006456032,
-0.010961176,
0.026856557,
-0.010103053,
-0.00010448942,
0.026199557,
0.029283436,
-0.005973338,
-0.0026849853,
-0.0020849698,
0.0074817566,
-0.019723412,
0.010143278,
-0.017564697,
0.003308465,
-0.008507482,
0.019361392,
0.019267535,
0.025234168,
0.015928902,
-0.0051118634,
0.0025576076,
0.0066605066,
0.004190052,
-0.03150919,
-0.010900839,
-0.0059968024,
0.017645147,
0.003787807,
0.018302146,
0.0034861232,
0.012228248,
-0.0020363652,
0.011350012,
-0.020192698,
-0.0046224655,
-0.022874331,
0.018798249,
-0.0047364347,
-0.04081446,
0.01037792,
0.0060169147,
-0.023678822,
-0.0059130015,
0.008085124,
-0.017926719,
0.077820994,
0.018288739,
-0.0038146232,
-0.0009234875,
-0.017739004,
0.014065166,
0.0017263014,
0.012965697,
-0.021479882,
-0.032769557,
0.012134391,
-0.026052067,
0.035799805,
-0.014802615,
-0.012590268,
0.0072068893,
-0.0141456155,
0.023879943,
-0.0043811183,
-0.0065398333,
0.031455558,
-0.013931084,
0.01323386,
0.009285155,
-0.012208136,
-0.005748751,
0.01499033,
-0.019897718,
0.01469535,
-0.032662295,
-0.009908635,
0.0058459607,
-0.050334256,
-0.018851882,
0.013012625,
-0.014467412,
0.003935297,
-0.014574677,
-0.002334697,
0.01403835,
0.009855002,
0.005490644,
-0.016036168,
-0.029283436,
-0.0018419469,
-0.036979724,
-0.022820698,
-0.024925781,
-0.011323197
] |
Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection of data from 503 liver cancer genomes from different populations uncovered 30 candidate driver genes and 11 core pathway modules. Furthermore, a collaboration of two large-scale cancer genome projects comparatively analyzed the trans-ancestry substitution signatures in 608 liver cancer cases and identified unique mutational signatures that predominantly contribute to Asian cases. This work elucidates previously unexplored ancestry-associated mutational processes in | [
0.0015774798,
0.0042371745,
0.01700109,
-0.02991563,
-0.0414156,
-0.010458683,
-0.030387156,
0.037800573,
-0.03342587,
-0.0034971426,
-0.011185617,
0.0037558263,
-0.003282664,
0.007943884,
0.011002246,
0.020812582,
0.038376883,
-0.0439042,
0.00041197025,
0.008120705,
-0.03292815,
0.0009070304,
0.0066471905,
-0.011126677,
-0.009495987,
0.041703753,
0.020498233,
-0.027086481,
-0.002048186,
-0.028763015,
0.016922502,
0.0059235306,
-0.014289822,
0.0026015728,
-0.0073282816,
0.014944717,
0.0058351196,
-0.02220096,
0.009594221,
-0.009247126,
0.005599357,
-0.0015332743,
-0.0121810585,
0.0072169495,
-0.004040706,
0.011513065,
0.005255537,
-0.015193578,
-0.010936757,
0.024073962,
-0.008330272,
0.021362694,
-0.011689886,
0.00084154087,
0.010157431,
0.013779003,
-0.001383467,
-0.0008202567,
0.0031598713,
-0.009404301,
0.017970335,
0.0013433546,
-0.02986324,
0.00884764,
-0.015507928,
0.013896884,
0.015154284,
0.025383754,
0.0064081536,
0.02032796,
0.043327894,
0.017485712,
-0.005933354,
-0.0032859386,
0.006725778,
-0.02095666,
-0.029208343,
-0.011637495,
-0.020681603,
0.018612133,
0.010884365,
-0.009895473,
0.015245969,
0.0031533223,
0.0063885064,
0.019044364,
-0.001325345,
0.010026451,
0.017983433,
0.00035405293,
-0.020432742,
0.0017092775,
0.00090539316,
0.009757944,
-0.0059006093,
-0.004273194,
0.008755954,
0.0047021504,
-0.0012418458,
-0.024807446,
-0.015219774,
0.015521025,
-0.010000256,
-0.013255087,
-0.026077943,
-0.0016053128,
0.01637239,
0.01405406,
0.0066013476,
-0.0069025997,
-0.0064245258,
0.044061378,
-0.0038999033,
-0.016005648,
0.014892326,
-0.01655576,
0.007564044,
0.0020743818,
-0.00096760824,
-0.011552358,
0.009214381,
0.020354155,
0.01455178,
-0.004289566,
0.0033890847,
0.023942983,
-0.039372325,
0.011539261,
-0.0013482663,
-0.014276724,
0.004007961,
-0.026798328,
0.018743113,
0.037224267,
-0.031461183,
0.00049894856,
-0.015521025,
-0.018795503,
-0.015232871,
-0.03436892,
0.004289566,
0.026628055,
-0.019961217,
0.008919678,
-0.016215215,
0.016333096,
0.032220863,
0.013503947,
0.0025704652,
-0.009299518,
0.008042118,
0.0065063876,
0.030203786,
-0.0075116525,
0.0074003204,
-0.0063197426,
0.008566034,
0.020878071,
-0.009915119,
-0.025174187,
-0.0038966287,
-0.0018942856,
-0.0009438683,
0.0068895016,
0.012790111,
0.027715182,
0.02590767,
-0.022554604,
0.0033759868,
-0.022633191,
-0.020786386,
0.024532389,
-0.025632614,
0.011388634,
-0.011951845,
0.0034774956,
-0.004705425,
0.034237944,
-0.031068247,
-0.027531812,
-0.019895729,
0.026903111,
0.03670035,
-0.010681347,
-0.013831395,
-0.016359292,
0.024584781,
-0.006765072,
0.005677945,
-0.033583045,
-0.010805777,
0.017773867,
0.01461727,
-0.0062804488,
-0.64336944,
-0.019136049,
-0.0027636595,
-0.021244813,
0.01009849,
0.002835698,
0.013726612,
-0.00010949036,
-0.021323401,
0.010962952,
-0.025423048,
0.013019324,
0.030334765,
-0.0030681859,
-0.03376642,
-0.025580222,
-0.0019826964,
-0.0017420223,
0.02345836,
0.006342664,
-0.027924748,
-0.00031639644,
0.0031123913,
0.018847896,
0.003349791,
0.018166805,
0.007852199,
-0.012973482,
0.009928217,
0.026955502,
-0.021978296,
0.014067157,
-0.029706065,
-0.005527319,
0.04998163,
-0.016477173,
0.014119549,
0.02345836,
0.016974894,
0.043825615,
-0.0018582663,
-0.018389469,
0.017079677,
0.011303498,
-0.025003914,
0.015507928,
0.019240832,
-0.010858169,
0.007459261,
-0.008978618,
-0.013595632,
0.010091941,
-0.022187863,
-0.0010781218,
-0.007426516,
-0.026497075,
0.015573418,
-0.03958189,
0.009764493,
-0.002678523,
-0.012253096,
0.02365483,
-0.010511074,
-0.028186707,
0.007446163,
-0.00058695016,
-0.024309725,
0.0014595985,
-0.007898041,
0.00552077,
0.0076950234,
0.02797714,
-0.008212391,
-0.017655985,
0.028239097,
0.034526095,
-0.009705553,
0.0019712357,
-0.004754542,
0.014473192,
0.004944462,
0.0012271106,
-0.015534123,
0.012285842,
0.0024574958,
-0.02076019,
-0.015442438,
0.0019090207,
0.005953001,
0.0070466767,
0.030544331,
-0.003513515,
-0.00020260832,
-0.022436723,
-0.004296115,
0.03117303,
-0.029994218,
0.016516468,
-0.000277512,
-0.038743623,
-0.026235119,
-0.025619516,
0.009568024,
-0.006509662,
0.033897396,
0.00047520862,
-0.02114003,
-0.02120552,
0.04809553,
-0.036097847,
0.004774189,
0.008827993,
-0.00233634,
0.0036084747,
0.012141764,
-0.015704397,
-0.00476764,
0.006994285,
0.0020580094,
-0.02973226,
0.020341057,
0.025737397,
0.009856178,
-0.026955502,
0.021297205,
0.024375215,
-0.0008603691,
-0.018782405,
0.0012320223,
0.0046595824,
0.0098627275,
-0.026117237,
0.008107607,
-0.009103049,
0.022423625,
-0.018612133,
0.008284429,
0.004273194,
-0.023615535,
-0.026182726,
-0.027191265,
-0.020799484,
0.011585103,
0.005871139,
-0.016424783,
-0.0015250881,
-0.034342725,
-0.020904267,
0.002295409,
-0.0073544774,
0.020458939,
-0.016149726,
-0.0053799674,
0.0041094697,
0.0040177847,
0.015534123,
0.029889435,
-0.023261892,
-0.0010617495,
-0.008736308,
0.010746837,
0.023759613,
0.01041284,
0.012554348,
-0.0013048794,
-0.005494574,
-0.002261027,
0.016830817,
-0.0050197747,
-0.01172918,
-0.005838394,
-0.019738553,
0.0041323914,
0.018599035,
-0.012665681,
0.0026277686,
-0.012646034,
0.0011665327,
-0.0014424076,
-0.018022727,
-0.0026195825,
-0.015390047,
-0.014735151,
-0.01223345,
0.027060287,
0.035783496,
0.033347283,
0.008349919,
0.02923454,
0.0250825,
-0.024178745,
0.027243657,
-0.01700109,
0.015075697,
0.0058940602,
0.0035790044,
0.0062575275,
0.009954413,
0.0010511074,
0.0139099825,
0.013752808,
-0.018651426,
0.015638907,
-0.029077364,
0.03224706,
-0.029313127,
-0.008769052,
0.005023049,
-0.0149709135,
-0.0026605134,
0.012999678,
-0.0016282342,
-0.032770976,
0.009528731,
-0.011683337,
0.016031845,
-0.003295762,
-0.02220096,
-0.0054421825,
-0.018297782,
-0.0032662917,
0.005966099,
0.016608153,
-0.003158234,
-0.005183499,
0.016791523,
0.00715146,
0.031068247,
0.011349341,
-0.01360873,
-0.0043059387,
0.01958138,
-0.0052195177,
0.00046743173,
0.01931942,
0.010327703,
-0.0053472226,
-0.014879228,
0.0055109463,
-0.00683711,
-0.00027116772,
0.00872321,
0.0018517174,
0.002624494,
0.012816307,
-0.013274734,
0.022829661,
-0.007131813,
-0.027793769,
0.0036084747,
-0.00058654085,
0.025829082,
-0.0062804488,
-0.0006094622,
0.023013031,
-0.026680447,
0.00094059383,
0.01736783,
0.05364905,
0.008945874,
0.022659387,
-0.0013572711,
-0.006882953,
-0.011368988,
-0.012128667,
0.008074863,
0.0076950234,
-0.0015136275,
-0.004397624,
0.016110431,
-0.014512487,
-0.022240255,
0.012017334,
-0.035154797,
0.00049772067,
0.010773033,
0.012141764,
0.0114082815,
0.010930208,
-0.0037034347,
-0.026628055,
-0.030282373,
0.01769528,
0.037093285,
-0.002349438,
-0.027715182,
-0.008454702,
0.004679229,
-0.01273117,
0.004554799,
0.01700109,
0.0207078,
-0.011755376,
-0.0072169495,
0.0010224557,
-0.008009373,
0.007871845,
-0.011185617,
0.006267351,
-0.004266645,
-0.01022292,
-0.028081924,
-0.005939903,
-0.0071776556,
0.02860584,
0.02451929,
-0.0086184265,
0.009941315,
0.009273321,
-0.009843081,
-0.010930208,
-0.029470302,
-0.004849502,
-0.0009536917,
-0.0010969501,
-0.0029879613,
-0.017236853,
0.030727701,
0.02189971,
-0.00064384425,
-0.0039686672,
-0.023877494,
-0.035469145,
-0.002843884,
0.04571171,
0.018520448,
-0.018913385,
0.013752808,
0.031906515,
0.010321154,
0.011296949,
-0.019542085,
0.014564878,
-0.009378105,
-0.012017334,
0.018651426,
-0.0022593897,
-0.00038700236,
0.03360924,
0.01837637,
0.0015308184,
-0.03206369,
-0.024349019,
0.0007539486,
-0.014892326,
-0.022384332,
0.02766279,
0.04759781,
0.033032935,
-0.014446997,
0.010556917,
0.03557393,
0.0035986514,
-0.0101508815,
-0.02766279,
0.02847486,
0.0006512118,
0.032692388,
0.008153451,
-0.01800963,
0.015887767,
-0.0072562434,
0.0043419576,
0.009234028,
0.020524427,
-0.002205361,
0.03594067,
0.01298658,
0.02408706,
-0.005694317,
0.0023608985,
0.000849727,
0.0053603207,
-0.009548378,
0.0030026964,
-0.00586459,
-0.005589534,
-0.016660543,
0.018599035,
-0.011401732,
-0.0076688277,
0.0036936111,
0.010039549,
-0.0019188441,
-0.008159999,
-0.03549534,
0.005939903,
-0.006172391,
-0.0052358904,
0.000068559384,
-0.014525585,
-0.041546576,
-0.036412194,
0.0017747671,
0.021113833,
-0.018965777,
-0.02076019,
0.0055862595,
0.01461727,
0.0059071584,
0.025580222,
-0.03237804,
0.015874669,
0.030701505,
-0.005802375,
-0.004191332,
-0.020157687,
-0.021912808,
-0.007852199,
0.0061363718,
-0.0016175922,
-0.0072627924,
-0.00093813794,
0.022043785,
0.003713258,
-0.010399742,
0.0024214764,
0.016817719,
-0.01367422,
0.005137656,
0.012305488,
0.004980481,
-0.021166226,
-0.013936179,
0.009731749,
-0.030727701,
-0.021690141,
-0.019712357,
-0.00054601923,
-0.019961217,
0.007125264,
-0.012704975,
-0.012069726,
-0.018415663,
0.025606418,
-0.023196403,
0.020354155,
0.0026965325,
-0.0066275434,
0.012292391,
-0.0012557623,
-0.011264204,
0.0007695023,
-0.014577976,
0.0009913482,
0.0011739003,
0.024506193,
0.00037738358,
-0.015468634,
0.0061232736,
-0.009751395,
-0.0034218295,
-0.022030689,
-0.025920767,
-0.0021660673,
0.046157043,
-0.014355311,
-0.010065746,
-0.0048462274,
0.0030796465,
-0.0035266129,
0.0064408984,
-0.0026408664,
-0.0082254885,
-0.027584203,
0.004417271,
0.010465232,
-0.01142138,
0.00043345903,
-0.03601926,
0.0098627275,
0.013097912,
0.016699838,
-0.012567447,
0.007203852,
0.0004289566,
-0.014512487,
-0.010877816,
-0.015913963,
-0.017538104,
-0.0052588116,
-0.01675223,
0.047073897,
0.008638073,
0.018847896,
0.007701572,
0.022122374,
0.014643465,
0.0136218285,
-0.002396918,
-0.006453996,
0.009260224,
-0.021441283,
0.006719229,
0.00511146,
0.022266451,
-0.0032155374,
0.005776179,
0.024532389,
0.017904846,
-0.013464654,
-0.021048345,
-0.010714092,
-0.046707153,
-0.048331294,
0.0071121664,
-0.011807768,
0.011139774,
-0.014892326,
0.0012492134,
0.01305207,
-0.017380929,
0.005095088,
-0.014381507,
0.021428185,
0.0006168298,
0.007753964,
-0.011185617,
-0.0073282816,
-0.0029961474,
-0.0068567568,
-0.014014766,
-0.0134253595,
0.0054520057,
-0.009666259,
0.03544295,
0.007452712,
-0.03693611,
0.014329116,
0.019057462,
-0.041363206,
-0.006555505,
-0.007426516,
-0.01586157,
0.015599613,
-0.019790946,
0.01594016,
-0.004823306,
-0.025986258,
0.006591524,
-0.015337655,
0.019790946,
-0.007826002,
-0.028946385,
0.025475439,
0.029601282,
0.029653672,
-0.022803465,
0.040996466,
0.018179901,
-0.0065227603,
-0.030832484,
-0.0052195177,
0.015913963,
0.0050656176,
0.034578487,
0.017786965,
0.009803787,
-0.010825424,
0.015625808,
0.0059366287,
-0.030780094,
-0.030911073,
0.020838778,
-0.002842247,
0.021231715,
-0.0022986836,
0.00016177968,
-0.008697013,
-0.0041553127,
-0.004754542,
-0.0035888278,
0.0014890688,
-0.024794348,
0.00022839484,
0.015390047,
-0.0015823914,
-0.002678523,
-0.01774767,
-0.00872321,
-0.0025066128,
-0.029365519,
-0.0052031456,
0.008572583,
0.0032204492,
0.025855279,
-0.014997109,
-0.022266451,
0.0016929051,
-0.014905424,
0.00922093,
-0.020694701,
-0.0010846709,
0.044061378,
-0.011945296,
-0.025920767,
0.023013031,
0.029260736,
0.0090964995,
0.012495408,
0.0036837878,
-0.017538104,
-0.011637495,
0.006863306,
0.031906515,
0.007315184,
0.0023347028,
0.013752808,
-0.0015136275,
-0.011244558,
-0.04028918,
-0.02703409,
0.029758455,
-0.032770976,
-0.0023101442,
0.0018484428,
0.01787865,
0.03237804,
0.03153977,
-0.0022577527,
-0.038665038,
0.031958904,
-0.028815407,
0.016987992,
0.02264629,
-0.0006815007,
-0.034788053,
0.020786386,
-0.024060864,
-0.03311152,
0.006237881,
-0.0050165,
-0.005753258,
-0.03376642,
-0.0015299999,
0.0114082815,
0.016333096,
0.0024214764,
0.013687318,
-0.0021906258,
0.018913385,
-0.013490849,
-0.027453223,
0.0432755,
-0.034159355,
0.017210657,
0.014826836,
0.019725455,
0.008755954,
-0.023864396,
-0.021624653,
-0.0020334509,
-0.0040799994,
-0.0067781694,
-0.006630818,
0.022803465,
-0.015822278,
0.011964942,
-0.009306067,
-0.027950944,
-0.0072169495,
-0.0009536917,
0.010445585,
0.0050918134,
-0.00058899674,
0.013517045,
0.016857013,
0.010327703,
-0.022751072,
0.005903884,
-0.0014587799,
-0.012777013,
-0.05299415,
0.019096756,
-0.0070990683,
0.02640539,
0.019136049,
0.011807768,
-0.021546066,
-0.0034414765,
-0.043878004,
-0.026235119,
0.033714026,
0.024257334,
-0.009207832,
0.00778016,
0.012835953,
0.007158009,
-0.009849629,
0.019843336,
-0.011683337,
-0.028867798,
0.0052424395,
-0.027505616,
0.018075118,
0.02157226,
-0.014342214,
-0.010497976,
0.020616114,
0.02496462,
-0.033661634,
0.0035953769,
-0.010622406,
0.014316018,
-0.03117303,
0.012777013,
-0.018585937,
-0.014145745,
0.011755376,
-0.010406291,
-0.014027864,
0.002850433,
-0.0043255854,
-0.008415408,
-0.005268635,
0.0072627924,
0.02716507,
0.026876915,
0.0050590686,
-0.034237944,
0.03104205,
-0.015481732,
-0.0018386194,
-0.008651171,
0.0188217,
0.018323978,
0.02014459,
0.0017207382,
0.0010691171,
-0.03544295,
-0.005327576,
-0.011152872,
-0.0141981365,
-0.010714092,
-0.008939325,
-0.013327125,
-0.0238382,
-0.027610399,
0.00025868375,
-0.015652005,
-0.039922435,
-0.015900865,
0.039870042,
-0.0013736435,
-0.0131765,
-0.02214857,
-0.0032417332,
-0.04628802,
-0.018730015,
-0.02451929,
0.009266772,
-0.019149147,
0.030020414,
-0.0037623753,
0.0019876081,
0.002966677,
0.0066406415,
-0.02503011,
-0.015324557,
-0.006041412,
0.1831612,
-0.020406546,
-0.01053727,
0.020066,
-0.010622406,
-0.003246645,
0.036674153,
0.03544295,
-0.0066078966,
0.019489693,
0.016306901,
-0.017407125,
-0.013386066,
0.009541829,
0.01493162,
-0.033845004,
-0.049510106,
-0.00058121985,
-0.019646868,
-0.0033563399,
0.0047021504,
-0.022476017,
-0.024545487,
-0.013196146,
0.011513065,
-0.011336243,
-0.03248282,
-0.0078391,
0.007446163,
0.002951942,
-0.0050918134,
0.002883178,
-0.017407125,
0.017276146,
-0.004734895,
0.0016225039,
-0.0032646547,
-0.010334252,
0.013451556,
-0.001551284,
-0.0016216852,
0.015573418,
-0.0021611555,
-0.02615653,
0.0017043658,
-0.0014677848,
0.021401988,
0.0016495183,
-0.0054978486,
-0.02721746,
-0.051134247,
-0.0076622786,
-0.0051540285,
0.01650337,
-0.028867798,
0.014368409,
0.029941827,
0.004034157,
-0.007164558,
0.011473771,
0.008932776,
0.014944717,
-0.016359292,
0.008631524,
-0.00617894,
0.032770976,
-0.009365007,
-0.012449565,
0.021244813,
-0.038481664,
0.0031549595,
-0.032613803,
-0.020026708,
0.011814317,
-0.00032171747,
-0.014525585,
0.013595632,
0.0050263237,
0.011781571,
0.028081924,
0.01286215,
-0.0016634348,
-0.027453223,
0.0052162437,
-0.00878215,
-0.04214908,
0.028867798,
0.020301763,
-0.016267607,
-0.00797008,
-0.0076819253,
0.009214381,
-0.008448153,
-0.028055727,
0.015036403,
0.012632936,
0.0010371909,
-0.008356468,
0.013150304,
-0.018664524,
-0.030151393,
0.06978568,
-0.013340224,
0.009266772,
0.00014755616,
0.010013354,
-0.010936757,
-0.006077431,
0.024886033,
0.010105039,
0.013818298,
-0.030596722,
0.01493162,
-0.008186195,
0.0047512674,
0.0244669,
0.014564878,
-0.030937267,
0.028893994,
-0.004240449,
-0.013883786,
-0.029313127,
0.008369566,
0.037040897,
-0.009319165,
-0.0003904815,
-0.014800641,
-0.014329116,
0.0010887639,
-0.03368783,
0.008755954,
-0.012528153,
-0.0009856179,
0.0043747025,
0.0134253595,
-0.014800641,
0.005638651,
-0.020052902,
-0.025383754,
0.008683915,
-0.003726356,
-0.009757944,
0.011316596,
0.021873513,
-0.014080255,
-0.014289822,
0.0029208343,
0.0051081856,
-0.01938491,
-0.008487447,
-0.029653672,
-0.010452134,
-0.04183473,
0.027191265,
0.016595054,
-0.0124692125,
-0.012980031,
-0.016909404,
0.0034054571,
-0.0024100158,
-0.02026247,
0.012803209,
0.015874669,
-0.018088216,
-0.0055928086,
0.0038638841,
-0.16398586,
0.011630946,
0.001856629,
-0.036359802,
0.034788053,
0.021415086,
-0.0057860026,
-0.01311101,
0.02026247,
-0.0027521988,
0.03963428,
-0.008900031,
-0.04524019,
-0.017328538,
0.018716916,
-0.014800641,
-0.011185617,
0.040132,
0.02559332,
-0.0057860026,
0.03858645,
-0.019267028,
0.005622279,
-0.001609406,
-0.009738297,
0.0012402085,
-0.007956982,
-0.013844493,
-0.007911139,
0.0019237559,
-0.0012876885,
0.008074863,
0.012993129,
-0.011152872,
-0.009057206,
-0.0009815248,
-0.010144332,
0.0064900154,
-0.019699259,
-0.008101058,
0.018035825,
0.036988504,
0.016739132,
0.021310303,
-0.013582535,
0.025711201,
0.005582985,
-0.0081338035,
0.029391715,
0.010792679,
0.0131765,
-0.00093322626,
0.035862084,
0.014944717,
0.020799484,
-0.0057794536,
0.01549483,
-0.006526035,
0.014512487,
0.0025098873,
-0.027898552,
-0.005072166,
0.008742856,
0.0026375921,
0.004021059,
-0.024178745,
-0.022030689,
0.0219521,
-0.0250825,
0.015769886,
-0.01988263,
-0.013805199,
0.01235788,
-0.021781828,
0.03751242,
0.0064769173,
-0.0056484747,
0.025527831,
0.003644494,
-0.020786386,
-0.009528731,
-0.0014243979,
-0.023536948,
-0.027898552,
-0.008965521,
0.01060276,
0.009666259,
0.020904267,
-0.0001342536,
-0.0188217,
0.026811427,
-0.036490783,
-0.012351331,
-0.023432165,
-0.0090899505,
0.018546643,
0.004178234,
-0.015141186,
-0.002596661,
-0.008127254,
0.016280705,
-0.010497976,
-0.0207078,
0.02928693,
0.034919035,
-0.0013040609,
-0.020052902,
0.012973482,
0.04791216,
-0.0039031778,
-0.013530144,
0.01486613,
0.010674798,
0.0010789405,
-0.012953835,
0.03801014,
-0.021323401,
-0.004610465,
-0.013065167,
-0.0052981055,
0.05532558,
0.010766484,
0.023039227,
0.009495987,
0.024820544,
0.003958844,
-0.1241682,
0.0027718456,
-0.00044410108,
0.007832551,
-0.007701572,
0.039791457,
-0.01988263,
0.012200705,
-0.023615535,
0.05013881,
-0.020432742,
-0.0070597744,
-0.0082254885,
-0.011899453,
0.01920154,
-0.00922093,
0.013634927,
-0.0037165326,
-0.0066733863,
0.035338167,
-0.0008284429,
-0.010406291,
0.0008083868,
-0.02797714,
0.006994285,
-0.003506966,
-0.023510752,
0.0028242373,
0.006981187,
0.020223176,
0.002411653,
0.0028946386,
-0.0063000955,
-0.016097333,
-0.0027702083,
-0.03311152,
0.008081412,
-0.008854189,
0.017145166,
-0.0017567575,
0.011251107,
0.005478202,
0.011748827,
-0.013752808,
0.007930785,
-0.017931042,
-0.026130334,
0.009954413,
0.016778424,
-0.013392615,
-0.011401732,
-0.010105039,
-0.016595054,
-0.022685584,
0.0068895016,
-0.023890592,
-0.01009849,
0.015573418,
-0.016712936,
-0.00031414523,
-0.0022708506,
-0.0049968534,
-0.010989148,
0.01800963,
0.03224706,
-0.021113833,
-0.0018795504,
-0.0071776556,
0.0066275434,
-0.037983947,
-0.016136628,
0.010779582,
-0.016398586,
-0.014918522,
-0.020066,
0.005006677,
0.00018633826,
0.0028749916,
0.0059300796,
-0.021978296,
-0.0060577844,
-0.0060446863,
0.016215215,
-0.030701505,
0.0038049435,
0.018481154,
-0.0018353449,
-0.005337399,
0.0067388755,
-0.033452068,
-0.0037361793,
0.03711948,
-0.01016398,
-0.011833964,
0.013962374,
0.013896884,
-0.011657142,
0.007118715,
0.010033,
0.033661634,
-0.016896306,
0.00009797852,
-0.05357046,
0.016398586,
-0.013844493,
-0.015337655,
0.0035397108,
-0.0077932575,
0.024741955,
-0.007452712,
-0.023183305,
0.032770976,
-0.009738297,
0.014708955,
-0.0043419576,
0.0013924717,
-0.016333096,
0.0038442372,
0.006624269,
0.006437624,
0.028815407,
0.037669595,
-0.0038376881,
0.015468634,
0.0067716204,
0.00072161306,
-0.014185038,
0.0035004169,
-0.002747287,
0.03350446,
-0.009679357,
-0.0054585547,
0.008886933,
-0.004260096,
-0.004728346,
0.010085392,
0.011716083,
-0.026077943,
0.024244236,
0.0005255537,
0.028867798,
0.05024359,
-0.013936179,
-0.0043059387,
0.0095745735,
0.012141764,
-0.0033039483,
0.004954285,
-0.029968023,
0.019149147,
0.0070401276,
0.015324557,
0.034237944,
0.007826002,
-0.0028962758,
-0.0084219575,
-0.0031173031,
-0.006336115,
0.009509084,
-0.0131765,
-0.0034480253,
-0.033085328,
0.014735151,
0.022908248,
0.017996531,
0.011493417,
-0.0014014766,
-0.021611555,
-0.03706709,
-0.0045089563,
0.032797173,
-0.023694122,
-0.005844943,
0.0031958905,
-0.0022839485,
0.011447575,
-0.008893482,
-0.018166805,
-0.0070663234,
0.008880384,
0.0016225039,
-0.0037754732,
-0.007144911,
0.0051900474,
-0.004246998,
0.033268698,
0.030518135,
-0.007347929,
-0.0035364362,
0.0066177202,
0.015167383,
0.015298361,
0.0067126798,
0.027322244,
0.0054356335,
0.017721474,
-0.00013404894,
0.014813739,
-0.009856178,
-0.009234028,
0.02554093,
0.031382598,
-0.0058351196,
0.009378105,
-0.00598902,
-0.0038049435,
-0.021375792,
0.00114443,
-0.016699838,
-0.024833642,
0.012161411,
0.0031729692,
0.01855974,
0.009685906,
-0.019358713,
-0.014093353,
-0.00746581,
-0.0022626643,
-0.026064845,
0.004505682,
-0.0057696304,
0.033714026,
0.02182112,
0.01373971,
0.00063565804,
-0.0018124236,
0.021506771,
0.015285264,
0.032954346,
-0.0036903366,
0.020249372,
-0.013346773,
0.011997688,
-0.00960077,
-0.02610414,
-0.012403723,
-0.024833642,
0.0042764684,
0.0067028566,
-0.002540995,
-0.010962952,
0.067270875,
-0.00075763237,
-0.031015856,
0.014905424,
-0.010137784,
0.02734844,
0.023916787,
0.02554093,
0.0026294058,
-0.013517045,
-0.004993579,
-0.02703409,
-0.003962118,
-0.052601214,
-0.004178234,
0.020917365,
-0.0010118138,
0.020118393,
0.015822278,
-0.013634927,
0.016464075,
0.009993707,
0.01912295,
0.019463498,
-0.027269853,
-0.003246645,
0.035338167,
-0.0033858102,
0.015468634,
-0.026981698,
-0.0026588761,
-0.010118137,
-0.024702663,
0.004842953,
0.0023134188,
-0.0012664044,
0.0070728725,
-0.036045454,
0.030701505,
0.014708955,
0.0011796308,
-0.007092519,
-0.0078456495,
-0.030780094,
-0.010858169,
-0.009273321,
-0.023314284,
-0.0051409304,
0.0068174633
] |
Mitotic chromosomes are among the most recognizable structures in the cell, yet for over a century their internal organization remains largely unsolved. We applied chromosome conformation capture methods, 5C and Hi-C, across the cell cycle and revealed two distinct three-dimensional folding states of the human genome. We show that the highly compartmentalized and cell type-specific organization described previously for nonsynchronous cells is restricted to interphase. In metaphase, we identified a homogenous folding state that is locus-independent, common to all chromosomes, and consistent among cell types, suggesting a general principle of metaphase chromosome organization. Using polymer simulations, we found that metaph | [
-0.019460496,
0.016102504,
-0.003933083,
-0.00830244,
-0.034293838,
0.013947571,
-0.011825689,
0.018336758,
-0.02908498,
0.0024160366,
0.01512419,
0.0087056635,
0.014278081,
0.0028374381,
-0.0026754877,
0.026824284,
0.033659257,
-0.011171277,
-0.018283878,
-0.015534024,
-0.035430796,
0.008632951,
-0.009320415,
-0.038365733,
-0.011792637,
0.025105627,
0.0064515774,
-0.018495403,
0.006256576,
-0.026189703,
0.011118395,
0.004865124,
-0.00026606148,
-0.028106667,
-0.018627608,
-0.012109929,
0.022633404,
-0.0017979806,
0.009267532,
-0.014317743,
0.011039073,
0.0014699483,
-0.024563588,
-0.0067622582,
-0.016948612,
0.018865576,
-0.025991397,
-0.0019285325,
-0.019209309,
0.021271698,
0.01483334,
0.027234118,
-0.03527215,
0.008765155,
-0.012704848,
-0.018535065,
0.0036686738,
-0.0045180875,
-0.010477203,
-0.02847684,
0.015190292,
-0.017437767,
-0.020385928,
0.02374392,
0.0019995924,
-0.011078734,
0.003794268,
-0.0019169647,
0.012519762,
-0.010847376,
0.02934939,
0.021483224,
-0.0134518035,
-0.003273713,
0.014806899,
-0.03112093,
-0.0207561,
-0.023215102,
-0.012612306,
0.014555711,
0.0068944627,
-0.01686929,
0.0033282472,
0.024140535,
0.003976049,
0.004587495,
0.0132006155,
-0.00087833335,
0.022673065,
-0.0060615744,
0.020280164,
0.027921582,
0.018918458,
0.018112011,
-0.02966668,
-0.000526339,
-0.0033728662,
0.018812694,
0.0030506179,
-0.01452927,
-0.017384887,
0.013987232,
-0.011984334,
-0.01812523,
-0.034320276,
-0.015005206,
0.048519038,
-0.016657762,
0.009981437,
-0.02575343,
-0.00082545157,
0.030486349,
-0.009122108,
-0.03582741,
0.012493322,
-0.011739756,
-0.008857699,
-0.0038438446,
-0.0069737853,
-0.019976094,
0.0026358264,
0.040507447,
0.011885181,
-0.030433467,
0.02106017,
-0.0032092633,
-0.04230543,
-0.0067754784,
-0.0059095393,
-0.010146692,
0.019447276,
0.0040223207,
0.0016261148,
0.010311948,
-0.022659844,
-0.010523475,
-0.004032236,
-0.0011460474,
-0.0046106307,
-0.023823243,
0.009274143,
0.026269026,
0.008870919,
-0.0009708765,
0.017979806,
0.014132657,
0.007178702,
0.014595373,
0.0021384072,
0.004944447,
0.014251641,
0.007938878,
0.032205008,
0.020147959,
0.012916376,
0.03357993,
8.1336725e-7,
-0.0018789559,
-0.011316702,
-0.02577987,
-0.0068085296,
0.021390682,
0.017596414,
0.015890976,
0.010715172,
0.026824284,
0.009227871,
-0.00890397,
0.011376194,
-0.004207407,
-0.008500746,
-0.0056021637,
-0.039978627,
0.012566034,
-0.012579254,
0.011799248,
0.006765563,
0.005747589,
-0.03968778,
-0.028820572,
-0.008342101,
0.028053787,
0.022487978,
0.0013774052,
-0.013121293,
0.004957667,
0.007482772,
0.00016308659,
0.01749065,
-0.008454476,
-0.014740797,
-0.009961606,
0.009009734,
-0.00563191,
-0.6269664,
-0.007945488,
0.0063557294,
-0.055684518,
0.012354507,
0.03022194,
0.009994657,
0.0004154112,
-0.021826956,
-0.0064317468,
-0.021893058,
0.024180196,
0.01275112,
-0.030486349,
-0.036911484,
-0.050317015,
-0.007760402,
-0.011779417,
0.005988862,
0.014754018,
-0.005651741,
-0.017966585,
-0.023836464,
-0.0022821794,
0.00057385,
-0.004296645,
0.050845835,
-0.00023982715,
-0.0024408249,
0.03283959,
-0.039819982,
-0.0007519129,
-0.009756689,
-0.021602208,
0.04294001,
0.0048552086,
-0.0077339606,
0.016591659,
0.026004616,
0.030380584,
-0.0073373476,
-0.0069539547,
0.009816181,
0.023929007,
-0.02429918,
0.0047329194,
-0.0012534636,
-0.026295466,
0.01864083,
0.014000452,
-0.006015303,
-0.021007288,
-0.023056457,
0.016366912,
0.005370806,
0.002893625,
0.019090325,
-0.012043826,
0.008884139,
0.007211753,
0.0065970025,
0.005017159,
-0.021959161,
-0.023056457,
-0.029243626,
0.030750757,
0.0008857699,
-0.011719925,
0.0013641848,
0.011019242,
-0.009551772,
0.03469045,
-0.011726536,
-0.031332456,
0.009069226,
0.017160138,
0.012387558,
0.015467921,
0.0046469867,
0.015507583,
0.0111448355,
-0.005063431,
-0.028397517,
-0.025079185,
0.024986643,
0.00004903443,
-0.007588536,
0.012209082,
0.011210938,
0.003939693,
-0.005605469,
0.0026754877,
0.024471045,
-0.031861275,
-0.01038466,
0.020266943,
-0.003794268,
0.010126862,
-0.0033117216,
-0.03379146,
-0.009340245,
-0.017953366,
-0.005522841,
0.014793679,
0.004058677,
0.015441481,
-0.04272848,
0.0020177707,
0.043733235,
-0.014687915,
-0.0009907072,
-0.017424548,
-0.021430343,
-0.0046833428,
0.00081264426,
-0.017636076,
0.023823243,
0.033368405,
-0.009750078,
-0.025515461,
0.018164892,
0.001748404,
-0.0030886268,
-0.0094261775,
0.026176482,
0.005228686,
0.0014889527,
-0.017226242,
-0.019486938,
0.004187576,
0.014635034,
0.00518572,
0.03051279,
-0.0314911,
0.017979806,
0.012519762,
0.00081264426,
-0.011052293,
0.005251822,
-0.015970299,
-0.026877167,
0.0069142934,
0.0012914723,
-0.0075687054,
-0.0002286724,
-0.019156426,
-0.051797707,
0.006289627,
-0.0012782519,
0.0053179245,
-0.011964504,
0.022620182,
-0.022924254,
0.0006399522,
0.01632725,
0.0016153732,
-0.008573459,
-0.019685244,
-0.010047539,
-0.03199348,
0.014463168,
-0.0006077274,
-0.027895141,
0.012936207,
0.0045775794,
-0.00055773754,
-0.008097523,
-0.0067457324,
0.0015220038,
-0.027445646,
0.020875083,
-0.018257435,
-0.033765018,
-0.00037203162,
-0.0046701226,
0.024537148,
0.008910581,
-0.01663132,
-0.0029432017,
-0.014661474,
0.0025069271,
-0.01571911,
-0.018164892,
-0.015467921,
0.02815955,
0.0053774165,
0.05105736,
-0.002209467,
-0.0171998,
0.035536557,
0.018601168,
0.0010617671,
0.0008287567,
-0.00682175,
0.015335717,
0.008044641,
-0.011045682,
-0.006041744,
-0.0038008783,
0.043468826,
0.024999863,
0.0050502103,
-0.025079185,
-0.012876715,
0.023281205,
-0.03707013,
-0.010920089,
-0.013101462,
0.0023515867,
-0.00015348112,
0.0075224335,
-0.011105174,
-0.007852945,
-0.0038471497,
0.0076281973,
0.014000452,
-0.015957078,
-0.002027686,
-0.007899216,
0.008157015,
0.0023862906,
-0.010113641,
0.028926335,
-0.006306153,
-0.00086015527,
-0.0033910444,
0.025925294,
0.032495856,
0.002700276,
0.0033431202,
-0.018852355,
0.049655996,
-0.005539367,
0.006322678,
0.015269615,
0.016829628,
0.03379146,
-0.011164666,
0.0457163,
0.0132601075,
0.01898456,
0.0071126,
0.0067754784,
-0.024219858,
0.01393435,
0.0026391316,
0.027287,
0.0003639754,
0.0017550142,
-0.0026887082,
-0.012883324,
-0.0065606465,
-0.026533434,
0.015785212,
0.005046905,
-0.022686286,
-0.002272264,
0.013418753,
0.03437316,
0.01895812,
-0.0064449674,
-0.021893058,
0.004091728,
0.0053774165,
-0.010100421,
0.00004012612,
0.024114093,
-0.00064160477,
-0.04539901,
0.01750387,
-0.016538778,
0.004323086,
0.017067596,
-0.015229953,
-0.0096905865,
-0.009512111,
-0.00044081925,
0.012876715,
0.021615429,
-0.0010105378,
-0.015917417,
-0.032680944,
-0.00020409064,
0.037731152,
-0.005668266,
-0.020994067,
-0.021483224,
-0.005869878,
-0.014886222,
0.015890976,
-0.015097749,
0.000556085,
-0.0129956985,
-0.005426993,
-0.03283959,
-0.012182641,
0.011316702,
-0.008639561,
0.020927966,
0.009545162,
-0.0062069995,
0.011951283,
-0.00079487934,
0.0077868425,
0.026440892,
0.014423506,
0.008791597,
-0.01333943,
-0.006312763,
-0.037889797,
-0.011647213,
-0.020306604,
-0.004951057,
-0.0015096096,
-0.02223679,
-0.0058236066,
-0.0147143565,
0.012975868,
0.02254086,
0.000045961708,
-0.013603839,
-0.011475347,
-0.016274368,
-0.0075224335,
0.029560916,
0.018164892,
-0.019341512,
0.0074893828,
-0.0044288496,
0.0042900345,
0.014304522,
-0.013081632,
0.026625978,
-0.012989088,
-0.02107339,
-0.015044867,
0.01452927,
-0.0031547288,
-0.0019549734,
0.025964955,
-0.008745325,
0.007905827,
-0.012784171,
0.020861864,
0.0097038075,
-0.0010501991,
0.038154207,
0.038127765,
0.010060759,
-0.0119380625,
0.0072976863,
0.025568342,
-0.016670981,
-0.01336587,
-0.0038008783,
0.018442523,
0.025991397,
0.012618915,
-0.010411101,
-0.020994067,
0.010596188,
0.008097523,
0.003559605,
-0.001971499,
0.0013782314,
0.007495993,
0.004944447,
-0.0004561054,
0.008864309,
0.02193272,
0.022977134,
0.0013732738,
-0.011812468,
0.0062499656,
0.033421285,
-0.023876125,
-0.00083578005,
-0.013802146,
-0.021139493,
-0.0013658373,
-0.029640239,
-0.01156789,
-0.011488567,
-0.0016666024,
0.0012352854,
-0.033923663,
0.0070993793,
-0.009016344,
-0.007443111,
-0.020121519,
-0.0062334402,
-0.022911033,
-0.041565083,
-0.0021483225,
-0.0025383255,
-0.05190347,
-0.04870412,
-0.024484266,
0.03551012,
0.027710054,
-0.0008700706,
-0.03262806,
-0.0020028974,
0.028238872,
-0.021721192,
-0.0025168424,
0.0004751098,
-0.0135245165,
-0.017583193,
-0.013841807,
0.018535065,
-0.013385701,
-0.013696382,
0.015229953,
0.012532983,
-0.02905854,
0.011389414,
0.009459229,
-0.015084528,
0.027035812,
0.0010658985,
0.032866027,
-0.001721963,
-0.012579254,
0.000434209,
-0.029190745,
-0.01660488,
-0.001165878,
-0.0016161995,
-0.0064086113,
-0.01602318,
0.009155159,
-0.019420834,
0.0015980214,
0.0013369176,
-0.0284504,
0.010404491,
0.0020805676,
0.019804228,
0.027789377,
-0.007819894,
0.027313441,
0.0015459659,
-0.030142616,
0.010622628,
-0.0053741112,
0.028053787,
-0.009650925,
-0.023505952,
0.02106017,
-0.007383619,
-0.014925883,
-0.013775704,
-0.0037215555,
-0.008150405,
0.033923663,
-0.0060549644,
-0.03500774,
0.01602318,
-0.00036376884,
0.008236337,
0.019143205,
0.019896772,
0.013987232,
0.00800498,
-0.014568931,
0.00035943088,
-0.020240502,
-0.003217526,
-0.03283959,
-0.0044024084,
0.00666641,
-0.00979635,
0.03492842,
0.004329696,
0.0071853125,
0.00018012857,
-0.016803186,
0.00050320325,
-0.024775116,
-0.010338388,
-0.011138226,
0.02193272,
0.03051279,
0.0343996,
-0.004240458,
0.009241092,
0.021271698,
0.020967627,
-0.012843663,
-0.010906868,
0.003999185,
-0.023836464,
0.035351474,
0.009697197,
0.012341286,
-0.0008857699,
-0.0018343369,
0.023889346,
0.029137863,
-0.00947906,
-0.052749578,
-0.00092047354,
-0.033632815,
-0.022646625,
0.00887753,
-0.0046106307,
-0.03228433,
-0.016538778,
-0.0026093854,
0.021390682,
-0.0028737944,
0.0041644406,
-0.0027448952,
0.028291754,
-0.020716438,
0.025912074,
-0.013987232,
0.021826956,
-0.007006836,
-0.0030935844,
-0.017318783,
0.011647213,
0.022977134,
0.011977724,
0.016142165,
0.01837642,
-0.020822203,
-0.008692443,
0.0033877392,
-0.036990806,
0.006577172,
-0.007324127,
-0.035377912,
-0.0031795173,
-0.0057145376,
-0.016366912,
-0.0325223,
0.0015294403,
0.010635849,
-0.015851315,
0.006901073,
-0.0035761306,
-0.011541449,
0.025872413,
0.0023895956,
0.022091364,
-0.02695649,
0.030301262,
-0.027260559,
-0.0129956985,
-0.019394394,
-0.025383256,
-0.018230995,
0.017702177,
0.030063294,
0.004951057,
-0.00533445,
-0.016115723,
0.00949228,
0.007971928,
-0.011343143,
-0.045134604,
-0.017080816,
0.020808982,
0.002845701,
-0.001474906,
0.0028126498,
-0.027789377,
0.0021681532,
-0.007899216,
0.011290261,
-0.0026325213,
0.0038901162,
-0.01036483,
0.03260162,
-0.01098619,
0.02398189,
0.0019731515,
-0.010814325,
0.020822203,
-0.021232037,
-0.0038967265,
0.0069605648,
0.005122923,
0.021152714,
-0.014925883,
-0.009221261,
0.02340019,
0.02908498,
-0.029693121,
-0.0033497305,
-0.008798207,
0.04000507,
-0.00019871983,
0.020518132,
-0.004858514,
0.01869371,
0.0160364,
0.008989903,
-0.0023234934,
-0.013088241,
-0.00801159,
0.0028109972,
0.0391854,
-0.0009328677,
0.011329922,
-0.03892099,
-0.013683162,
0.01686929,
-0.03352705,
-0.021588989,
0.003972744,
-0.039344046,
-0.021826956,
0.008553629,
0.027710054,
0.027392764,
-0.0027068863,
-0.012347897,
-0.021324579,
0.03728166,
0.010616018,
0.02342663,
0.022368994,
0.0061309817,
-0.045478333,
0.01542826,
-0.015018427,
-0.025145289,
0.011719925,
-0.017133698,
-0.010338388,
0.0084412545,
0.018482184,
0.027895141,
0.004822158,
-0.017768279,
-0.007892606,
0.020253723,
0.01780794,
-0.0043197805,
-0.0144499475,
0.0068746316,
-0.0397671,
-0.007899216,
0.025343595,
-0.0077537913,
-0.008930411,
-0.005046905,
-0.030618552,
0.0058731833,
-0.012420609,
-0.020954406,
-0.0021433649,
-0.0034042648,
-0.0058236066,
0.0037579117,
0.0025069271,
-0.010199574,
-0.0030225245,
-0.002908498,
-0.018944899,
0.009446008,
-0.015864534,
0.013478245,
0.04116847,
0.009584824,
-0.023598496,
0.0010898605,
-0.00032596663,
-0.030671434,
-0.05097804,
0.006137592,
-0.015838094,
0.027948022,
0.0005519536,
-0.024801556,
-0.021403901,
-0.014079775,
-0.020637115,
-0.030274821,
0.0072514145,
0.009862453,
0.021536106,
0.029798886,
-0.01812523,
0.0030456602,
0.008256168,
0.015282836,
0.0058566574,
-0.0011609204,
0.028926335,
-0.013425363,
0.013577398,
0.0043991036,
-0.011984334,
-0.0006027697,
0.020518132,
-0.014291302,
-0.005552587,
0.0051658894,
0.016684202,
0.030882962,
0.0062433556,
0.0041677454,
-0.006570562,
0.0129956985,
0.036541313,
-0.031623308,
0.020346265,
0.005274958,
0.0060946257,
-0.016644541,
0.007846335,
-0.030169057,
-0.008487526,
0.016499117,
-0.017926924,
-0.035642322,
0.013749263,
-0.010523475,
0.005688097,
0.011614162,
-0.0036851992,
0.0046833428,
0.0043957983,
-0.005734368,
0.0013741001,
-0.0071390406,
-0.038709465,
-0.008870919,
0.018283878,
-0.012519762,
0.011125005,
0.014423506,
0.007932267,
-0.02107339,
-0.01541504,
-0.003440621,
-0.012757731,
-0.02611038,
0.019235749,
0.0044024084,
0.016961832,
-0.005076651,
0.005423688,
-0.021522885,
0.0070134467,
0.034531806,
-0.005539367,
-0.024153754,
0.018059129,
-0.009069226,
-0.008381763,
0.006319373,
-0.017622855,
0.0018161588,
-0.006752343,
0.016908951,
0.19523954,
-0.008209897,
-0.008930411,
0.021879839,
-0.004329696,
-0.02337375,
0.0034802824,
0.0076348074,
0.009564993,
0.0031398558,
0.022818489,
-0.011125005,
-0.011759587,
0.002060737,
0.030777197,
-0.011396024,
-0.0020673473,
-0.008937022,
-0.022606963,
0.010444152,
0.0026457417,
-0.03083008,
0.017609634,
0.0012732942,
0.00828922,
-0.020280164,
-0.019222528,
-0.0029580747,
-0.0052650427,
0.011924842,
-0.022421876,
0.0010369787,
-0.009089056,
-0.018601168,
-0.003473672,
0.001763277,
0.008666002,
0.008150405,
-0.00084197713,
0.0040950333,
-0.0036257072,
-0.008038031,
0.019830668,
0.0035662153,
0.011310091,
-0.0004145849,
0.011389414,
-0.0079124365,
0.031015165,
-0.022501199,
-0.038630143,
0.0032076107,
0.022474758,
0.033632815,
-0.0023416714,
-0.0011501788,
-0.0025862497,
0.011448906,
-0.0006684588,
0.009657536,
-0.02226323,
0.0018492099,
-0.0013270023,
-0.0000733838,
0.009161769,
0.024272738,
-0.013478245,
0.013802146,
0.026758183,
-0.022699505,
-0.0011733145,
0.00074860774,
-0.0177815,
-0.019235749,
0.0019004392,
0.0034637568,
0.051797707,
0.02285815,
0.025872413,
0.008692443,
0.016155384,
-0.010166523,
-0.0129229855,
0.0032307464,
0.012057046,
-0.02374392,
0.053780776,
0.017041154,
-0.018032689,
-0.038127765,
0.0036587585,
-0.009115498,
-0.013577398,
-0.018310318,
0.019473717,
-0.0026209534,
0.008229728,
-0.0026655723,
-0.014436726,
-0.010510255,
-0.0039529135,
0.048122425,
0.026863946,
0.010569747,
-0.0010444152,
-0.008328881,
0.01423842,
-0.010629239,
-0.0031894327,
-0.01780794,
0.014132657,
-0.022765609,
0.008798207,
0.0051097022,
0.0075224335,
0.022950694,
0.004792412,
-0.060390998,
0.036911484,
-0.0036224022,
-0.008811427,
-0.031517543,
0.0110126315,
0.022871371,
-0.0050237696,
-0.003946303,
0.012566034,
0.013431973,
0.0048552086,
-0.018918458,
0.00064036535,
-0.0026573096,
0.010840765,
0.005159279,
0.0012699891,
-0.024722233,
-0.0005800471,
-0.0022507808,
-0.0144499475,
-0.008355321,
-0.024550367,
-0.014291302,
-0.0026540046,
0.020544574,
-0.0024639606,
-0.0068085296,
0.0054435185,
0.03759895,
-0.020266943,
-0.04418273,
0.007053108,
-0.007383619,
-0.0027382849,
-0.016353691,
0.012526372,
-0.013075021,
-0.0025300628,
-0.03492842,
-0.011396024,
0.010853986,
-0.013114682,
0.016842848,
0.006907683,
0.014846561,
0.0015476184,
-0.0010535043,
-0.16509692,
0.01304197,
0.01812523,
-0.010728392,
0.017675737,
0.02102051,
0.008474306,
0.009677366,
0.007806673,
0.0063623395,
0.005430298,
0.003199348,
-0.035959613,
-0.010840765,
0.00022825926,
0.009399737,
-0.015441481,
0.024986643,
0.015586906,
0.008137184,
0.016380133,
-0.022408655,
0.023876125,
-0.010192964,
-0.0014178929,
0.021271698,
0.0064780186,
0.013974011,
-0.0027548105,
-0.03886811,
-0.003738081,
0.0027762935,
0.01628759,
0.004451985,
0.014119436,
0.0024540452,
-0.017847601,
-0.0071324306,
0.013174174,
-0.0091816,
0.022487978,
0.008685833,
0.002878752,
-0.0108804265,
-0.0007696778,
0.02698293,
-0.029931089,
-0.0011584415,
0.02699615,
-0.008751935,
0.0136567205,
-0.0106689,
0.013359261,
0.01870693,
0.029904649,
-0.0007415844,
0.010920089,
0.01718658,
0.011429075,
0.005846742,
-0.01686929,
-0.016128944,
0.020293385,
-0.006653189,
-0.010014487,
-0.022157468,
-0.0025399781,
-0.0044652056,
-0.013008919,
0.01187196,
0.004445375,
0.005073346,
0.010153302,
-0.027207678,
0.0213378,
0.02072966,
-0.0031795173,
-0.00034517757,
0.006788699,
-0.014859782,
-0.045002397,
0.021694751,
-0.025065966,
-0.03796912,
0.0004195426,
-0.0034075698,
-0.012076877,
0.024550367,
-0.02876769,
0.01606284,
0.011990945,
-0.03326264,
0.013603839,
-0.012308235,
0.049920402,
0.012651967,
-0.0030440076,
-0.032998234,
0.008104133,
-0.032786705,
0.024206636,
0.0073109064,
-0.0094988905,
0.028661927,
0.027895141,
0.012473491,
-0.011039073,
-0.006253271,
0.039211843,
-0.0074232803,
-0.010609408,
-0.016089283,
0.019341512,
0.020491691,
0.011786028,
0.04122135,
-0.003857065,
-0.007026667,
0.009340245,
-0.0076876893,
0.08254846,
-0.005694707,
-0.010179743,
0.0219195,
-0.00048130687,
-0.0054137725,
-0.13812722,
-0.025118846,
-0.012618915,
0.026533434,
0.0075687054,
0.022461537,
-0.008196676,
0.031861275,
-0.008659392,
0.04159152,
-0.013246886,
-0.009003123,
-0.018482184,
0.010999411,
-0.013841807,
0.00259947,
-0.008930411,
-0.00711921,
-0.005764114,
0.023915786,
-0.0007130778,
-0.0019698464,
-0.0049113957,
-0.04063965,
0.014000452,
-0.007026667,
-0.031914156,
0.023215102,
0.035774525,
0.024933761,
-0.006854801,
-0.008335491,
-0.0027482002,
0.011819079,
-0.007595146,
-0.0044024084,
-0.02106017,
-0.027049033,
0.03260162,
-0.013233666,
-0.021906279,
-0.0019648888,
0.00043544843,
-0.00861973,
0.006345814,
-0.016340472,
-0.0041049486,
0.0027482002,
0.0029217186,
-0.0016641236,
-0.014066555,
-0.015177072,
-0.025740208,
-0.026427671,
0.0010849028,
-0.00638217,
0.006289627,
-0.018720152,
-0.011951283,
0.010721781,
-0.0050667357,
-0.008196676,
0.012519762,
0.015957078,
0.03051279,
-0.0031233304,
-0.029508036,
-0.018482184,
0.035800967,
-0.019116765,
0.0049973284,
0.007866166,
-0.036488432,
-0.0016798229,
-0.018178113,
-0.004875039,
-0.03080364,
-0.008355321,
0.008361932,
-0.019962873,
-0.0020095077,
-0.022104586,
0.024259519,
-0.0054997057,
0.03741386,
0.00009409239,
0.0059458953,
-0.017424548,
0.01038466,
0.025065966,
0.0066961558,
0.04336306,
0.014397065,
-0.023334088,
-0.011534839,
0.012936207,
0.0060946257,
0.0016517295,
0.0062697963,
0.030486349,
-0.033103995,
-0.013577398,
-0.051771265,
0.012566034,
0.0070663285,
0.008824647,
0.004772581,
-0.018310318,
-0.006170643,
-0.0080182,
0.011118395,
0.027154796,
-0.009571603,
0.008923801,
-0.012050437,
-0.0183632,
-0.033077557,
-0.017001493,
0.010847376,
0.0032720603,
0.0036719788,
0.043786116,
-0.013517906,
0.001992982,
0.01626115,
0.0019202698,
-0.013293158,
-0.007377009,
-0.016512336,
0.030459907,
-0.012281794,
0.007654638,
0.037493184,
-0.019367954,
-0.011376194,
0.020372707,
0.004574274,
-0.020412369,
-0.012321455,
0.020266943,
0.021218816,
0.027657174,
-0.0013286548,
-0.031226693,
-0.007978539,
0.028503282,
-0.010133471,
0.0131279025,
-0.028899895,
0.0082495585,
-0.00024808993,
-0.0067556477,
0.019116765,
0.0116736535,
0.009683977,
-0.02966668,
-0.010867206,
-0.0057608094,
-0.003645538,
0.0047263093,
0.0058864034,
-0.027472086,
0.02337375,
0.039819982,
0.013603839,
-0.016710643,
-0.015586906,
-0.007390229,
-0.03051279,
-0.007991759,
-0.030327702,
-0.036065377,
0.00011020481,
0.030724317,
0.014344184,
0.004369357,
-0.0077339606,
0.0034141801,
-0.007178702,
0.015653009,
0.010536695,
0.026943268,
0.005698012,
-0.013868248,
-0.017860822,
0.018614387,
0.035563,
-0.012083488,
-0.013458414,
0.05248517,
-0.007806673,
-0.00093452027,
0.0014079775,
0.025065966,
0.004627156,
-0.010120251,
0.0065936972,
0.01866727,
-0.02285815,
0.027154796,
0.0024011636,
0.017715398,
-0.0070332773,
-0.005093177,
0.003440621,
-0.01421198,
-0.004468511,
-0.00022908553,
-0.009307194,
-0.039053198,
-0.008262779,
0.023849685,
0.017292343,
0.010523475,
0.012440439,
0.00006739329,
-0.014740797,
0.004544528,
0.0077273506,
-0.0071919225,
-0.00770091,
0.04000507,
0.0077339606,
0.030644994,
-0.0037909627,
0.0016261148,
0.024682572,
0.012532983,
0.016988274,
-0.027895141,
0.03204636,
0.0038438446,
0.035695203,
0.007377009,
-0.019777788,
-0.017160138,
-0.017887263,
-0.01274451,
-0.0021813735,
0.0009212998,
-0.012585864,
0.076096885,
0.0034240955,
-0.015454701,
0.020888304,
-0.005298094,
0.023810023,
0.009855842,
-0.01454249,
-0.0047527505,
-0.029719563,
-0.0014881265,
-0.025687326,
0.010054149,
-0.009327024,
-0.015005206,
0.041062705,
-0.0137889255,
-0.00415122,
-0.015163851,
-0.016856069,
0.0048254626,
-0.036276903,
0.014172318,
0.021165933,
0.0016674288,
0.004561054,
0.027762936,
0.004762666,
0.010146692,
-0.007899216,
0.0052617374,
-0.028979218,
-0.033976547,
-0.022818489,
0.0027795988,
-0.008632951,
0.018019468,
-0.031676188,
0.024127314,
0.014912663,
-0.019050663,
-0.0019450581,
-0.017041154,
-0.027260559,
-0.022091364,
0.016776746,
0.015018427,
-0.0076149767,
-0.02666564
] |
The concept of 'Compensatory anti-inflammatory response syndrome' (CARS) was proposed in 1997 by Roger Bone (1941-1997) to qualify the consequences of the counter-regulatory mechanisms initiated to limit the overzealous inflammatory process in patients with infectious (sepsis) or non-infectious systemic inflammatory response syndrome (SIRS). One major consequence of CARS is the modification of the immune status that could favour the enhanced susceptibility of intensive care patients to nosocomial infections. Indeed, most animal 'two-hit' models illustrate an enhanced sensitivity to infection after a first insult. However, this observation is highly | [
-0.021837376,
0.0041940883,
0.014942067,
-0.01934703,
-0.02369844,
0.0053790105,
-0.0008062658,
-0.005261857,
-0.0070760595,
-0.0024066635,
-0.011501107,
0.007263505,
0.0064835986,
0.016856687,
-0.0032719243,
-0.013629951,
0.04284464,
0.016776353,
-0.010202379,
-0.00512462,
-0.010630826,
0.0037556002,
-0.026550286,
-0.0071162265,
0.00023953666,
0.009017457,
0.015183068,
-0.046352543,
-0.008200731,
-0.025171224,
-0.0010493589,
-0.01159483,
-0.00063471985,
-0.000881997,
-0.012116999,
-0.021087594,
0.013087697,
-0.011842526,
0.0047095628,
-0.018235749,
0.031249806,
0.006326278,
0.00797312,
-0.002610845,
-0.012177249,
-0.0069756424,
0.022841547,
-0.024782944,
-0.023296772,
0.017044133,
0.043487307,
0.011260106,
-0.024100108,
0.012773057,
0.0038392812,
-0.015892683,
-0.009338792,
0.039952625,
0.009579793,
-0.024782944,
0.003809156,
-0.00013043765,
-0.021208094,
0.021060817,
-0.0013606519,
0.0013179746,
-0.008515372,
0.011802359,
-0.013563005,
0.0077923685,
0.044585202,
0.03224059,
-0.004890314,
-0.012726196,
0.017084299,
-0.012940419,
-0.012719502,
-0.005499511,
0.00803337,
0.013763839,
0.02100726,
-0.011280189,
-0.019574644,
0.019802256,
0.011012411,
-0.027313456,
0.01807508,
0.027822236,
0.011735414,
-0.006179,
0.009338792,
0.03837273,
0.013228281,
0.0021221484,
-0.020565426,
0.03644472,
0.008850096,
0.027795458,
-0.0072902828,
-0.02407333,
0.013295227,
-0.00016547904,
-0.018891808,
-0.02178382,
-0.01204336,
-0.01044338,
-0.013469283,
0.007464339,
0.0072501157,
-0.0012250888,
-0.005191565,
0.033820484,
0.00018974651,
-0.029187908,
0.05607292,
-0.00598486,
0.010028323,
0.010717854,
-0.02164993,
-0.029402133,
0.017593078,
-0.006098666,
0.01682991,
-0.005921263,
0.032776147,
-0.011809053,
-0.025198001,
0.0042643803,
-0.013897729,
-0.022533601,
-0.026965344,
0.020364592,
0.005784026,
-0.00073095295,
-0.00041840467,
0.023082549,
-0.03363304,
0.004980689,
-0.0040334207,
-0.031919256,
-0.0006359751,
0.031999588,
-0.04075596,
-0.013911118,
0.0010008239,
0.00924507,
0.009184819,
0.022439878,
-0.017941192,
0.0006217493,
0.004080282,
-0.036632165,
-0.0060584997,
-0.02127504,
0.013208198,
0.018262526,
0.005218343,
0.017151244,
-0.019146197,
-0.015209846,
0.012029971,
-0.02127504,
0.0056099696,
-0.0061856946,
0.0012234153,
0.0062559866,
0.0123178335,
0.01849014,
-0.014901901,
-0.0027028942,
-0.015209846,
0.024809722,
0.0018409805,
0.014219064,
-0.009258458,
0.0140450075,
-0.012572223,
0.013763839,
-0.013268448,
-0.034623824,
-0.014674288,
0.018048303,
0.046566766,
0.014634121,
0.0129538085,
-0.012572223,
0.029482465,
-0.021636542,
-0.014982234,
-0.011467635,
0.015236624,
0.015035789,
-0.015745403,
-0.03245481,
-0.6456687,
-0.021114374,
0.005881096,
0.00021150356,
0.002878624,
0.03328493,
0.0075446726,
-0.017378855,
-0.03146403,
0.043728307,
-0.025559504,
-0.0041639633,
0.0030024718,
0.0037321695,
-0.0010845049,
-0.023082549,
-0.010731243,
0.0030091663,
0.00052760827,
0.013014059,
0.024126885,
0.006195736,
-0.00301084,
0.01630774,
-0.009881045,
0.0064769043,
0.008568928,
-0.018142026,
0.012819919,
0.0074107833,
-0.0140048405,
0.027380401,
0.006420001,
-0.013656728,
0.053796798,
0.008013286,
0.0027229774,
0.023377106,
0.026282508,
0.045201093,
0.003581544,
-0.0034376127,
0.015330346,
-0.025131058,
-0.0031062362,
0.030633915,
0.007464339,
0.0029874092,
0.005784026,
-0.017941192,
0.022064988,
0.03475771,
0.0052718986,
0.0057405117,
0.03566816,
-0.019681755,
0.0044652144,
-0.021047428,
0.01292703,
0.012197332,
0.009773932,
0.013027447,
-0.00041631263,
-0.037140943,
0.011467635,
0.016642464,
-0.018061692,
-0.00010920362,
0.024247387,
0.00057907205,
0.0070760595,
0.018436583,
-0.0014033292,
-0.0008811602,
-0.014486843,
0.017499356,
0.010155518,
0.0105304085,
-0.018383028,
0.008294454,
0.0046794377,
0.012746279,
-0.018811474,
0.008796539,
0.015999794,
-0.018423194,
-0.014299397,
0.0039597815,
-0.0005824193,
-0.009753849,
-0.00525851,
0.015611514,
-0.035320047,
-0.0145002315,
-0.013696895,
0.034356043,
0.0051681343,
-0.006838406,
0.0040267264,
-0.0027263248,
-0.005968124,
-0.016374685,
0.010028323,
0.009057624,
0.0040032957,
-0.002980715,
-0.041586075,
-0.0056032753,
0.043433752,
-0.02166332,
0.02776868,
-0.009506154,
-0.0033807096,
-0.009974767,
0.01644163,
-0.01464751,
-0.0023447396,
0.013034142,
-0.0004502034,
-0.033927597,
0.0061756526,
-0.000535558,
0.009760544,
-0.0046727434,
-0.0011137932,
0.003681961,
-0.0094191255,
-0.021998044,
-0.008281065,
-0.03058036,
0.02102065,
-0.024033163,
0.012719502,
-0.013804006,
0.033874042,
-0.031919256,
0.028250683,
-0.007872702,
0.0069354754,
-0.043005306,
-0.0057204287,
-0.0135697,
0.0012008214,
0.017419023,
-0.015209846,
0.019387199,
-0.005954735,
0.005660178,
0.021475874,
-0.003909573,
0.010416603,
0.0007828351,
-0.023792163,
-0.006968948,
-0.017044133,
-0.0036384468,
-0.02511767,
-0.020525258,
-0.015464236,
-0.0041706576,
-0.009325403,
-0.002664401,
-0.00081505225,
0.008167259,
-0.015571347,
-0.0076116174,
0.01541068,
0.02790257,
-0.022265822,
-0.03071425,
0.0010200705,
-0.011360523,
-0.001715459,
0.021234874,
0.030285804,
0.0037556002,
-0.014968845,
-0.020967094,
-0.0007753038,
0.0023363717,
-0.013676812,
-0.028893352,
-0.00955971,
0.0018861681,
0.018958751,
0.004120449,
0.03135692,
-0.0056400946,
-0.0197487,
0.04359442,
0.011266801,
0.020351203,
-0.03580205,
0.022064988,
-0.007223338,
-0.025023947,
-0.013616561,
-0.019976312,
0.006490293,
0.017941192,
0.0127931405,
-0.00815387,
0.028009681,
-0.0046359235,
0.020819817,
-0.013395644,
0.012304444,
-0.013462588,
0.04394253,
0.012572223,
0.0062693753,
0.014834955,
0.018838251,
-0.011601524,
-0.0077254237,
0.015477625,
0.021971265,
0.000324682,
-0.0054827747,
-0.0030526803,
-0.031196252,
-0.0013916139,
0.048494775,
-0.013656728,
-0.017633246,
0.0076919515,
0.013134559,
0.0035949328,
0.0026961996,
0.0060082907,
-0.02851846,
0.0022828158,
0.008876873,
0.018958751,
0.013214893,
0.013234976,
0.013857562,
0.008488594,
0.050824452,
0.011213245,
0.0075513674,
0.007745507,
0.0037355167,
0.011072661,
0.011916164,
0.011768886,
0.02612184,
0.026925176,
-0.02281477,
0.036364384,
-0.028357795,
-0.0034610434,
-0.011260106,
0.012364695,
-0.011527885,
0.011829137,
0.03438282,
0.02993769,
0.041077297,
0.0145403985,
0.02292188,
0.010751327,
0.0072032544,
-0.022118544,
-0.006460168,
0.010021629,
-0.007799063,
-0.015464236,
0.010470158,
0.0035012101,
-0.032026365,
0.0017037438,
-0.0015246666,
-0.016106905,
0.016736187,
0.016896853,
0.017740358,
0.006630877,
0.020632371,
0.004217519,
0.019400587,
-0.025077501,
0.038426284,
0.003584891,
-0.014768011,
-0.0019999743,
-0.008053453,
-0.0025656573,
0.0074241725,
0.015892683,
0.026081672,
0.027420567,
0.013804006,
0.0052384264,
0.0027698388,
0.0043714917,
0.030392915,
-0.025305113,
0.005968124,
0.0005857665,
-0.0066777384,
-0.0074576447,
0.00089287554,
-0.029321799,
0.016963799,
0.0035079047,
0.0010476853,
-0.02905402,
-0.037863947,
-0.0059781657,
0.0151562905,
-0.017860858,
-0.01554457,
-0.033820484,
0.017660024,
0.0198692,
-0.0016769659,
0.001548934,
0.023979608,
-0.02851846,
0.0057739844,
-0.028866574,
0.017646635,
-0.021355374,
0.032053143,
-0.018784696,
-0.016937021,
0.028384572,
0.010088573,
-0.010182296,
-0.022600546,
-0.05821515,
0.028866574,
-0.014286009,
-0.02408672,
-0.008595705,
0.026577065,
0.008381482,
0.021328596,
0.022721047,
0.018008137,
-0.022787992,
-0.0077187293,
0.002259385,
0.018021526,
0.01337556,
0.030500026,
0.052457903,
0.022988826,
-0.043112416,
-0.004455173,
0.01603996,
-0.023484217,
-0.030232247,
-0.0135697,
0.006671044,
-0.029482465,
-0.010028323,
0.01190947,
-0.011554663,
0.01388434,
0.0023028993,
0.00465266,
-0.0024769555,
-0.0009974767,
0.025773726,
0.013556311,
0.007477728,
0.0020116896,
-0.015986405,
0.014433287,
0.0060584997,
0.0032367785,
-0.015491014,
0.029134354,
-0.0070024203,
-0.010905299,
-0.024180442,
0.012525362,
-0.01618724,
-0.0075781452,
-0.022734435,
-0.00063388306,
0.010108656,
-0.021475874,
-0.010717854,
0.0066375714,
-0.006125444,
-0.029803801,
-0.009814099,
0.0026510118,
-0.006674391,
-0.023336938,
0.0029689996,
0.007999897,
-0.042898193,
-0.011487719,
0.025412226,
0.016093517,
-0.0001972778,
0.015745403,
-0.0070827543,
0.01024924,
0.004558937,
-0.014768011,
-0.01796797,
-0.005787373,
-0.03869406,
0.0134291155,
-0.012565529,
0.010778104,
-0.022975437,
-0.0068819197,
0.010209073,
0.025559504,
-0.009017457,
0.012170555,
0.0005167298,
0.0033756888,
0.007953036,
0.008749678,
0.003946393,
-0.0014334543,
-0.050904784,
0.004682785,
-0.0105304085,
-0.011065966,
-0.010758021,
0.0023196354,
-0.035587825,
-0.0033388692,
-0.022895103,
0.014460065,
0.0003849323,
0.02037798,
-0.0007296977,
0.0020334467,
-0.022131933,
-0.009158041,
0.006332973,
-0.0002782391,
0.018838251,
0.005519594,
-0.0074576447,
0.001044338,
0.009091096,
-0.0038292394,
0.00073932105,
-0.0063831815,
0.00030229735,
-0.0037053917,
-0.005881096,
-0.03834595,
-0.023002215,
-0.02969669,
0.044826202,
0.008180648,
-0.005800762,
-0.020726094,
0.0012719502,
-0.0048434525,
0.024274165,
0.0056200116,
-0.013201504,
-0.019039085,
-0.0023514342,
0.012773057,
-0.017111076,
0.015450847,
-0.031223029,
0.0014677636,
0.016937021,
-0.018583862,
0.0035915857,
-0.012110304,
-0.0057472065,
-0.0025171225,
0.019922756,
0.002045162,
-0.040568516,
-0.0059446935,
-0.00024706795,
0.037248056,
0.03336526,
0.023859108,
-0.025184613,
0.008609095,
0.0150759565,
0.005630053,
0.006788197,
-0.028732685,
0.0067078634,
-0.015772182,
0.017740358,
0.016334519,
-0.005345538,
-0.009787322,
-0.0040401155,
0.017914414,
0.01796797,
0.0007276057,
-0.028223904,
-0.017767135,
-0.042630415,
-0.012364695,
0.014848345,
0.013288532,
0.007323755,
-0.032187033,
-0.0025054072,
0.011387302,
-0.011614913,
0.011226634,
-0.005881096,
0.03017869,
-0.008983985,
0.003835934,
-0.002137211,
0.009814099,
-0.008334621,
-0.015370513,
0.0015824065,
0.011286884,
0.0027179567,
0.008301148,
0.01089191,
0.020444926,
-0.005121273,
-0.010369741,
0.011072661,
-0.008401565,
-0.024983779,
-0.0015824065,
-0.0062827645,
0.0020702663,
-0.001312117,
-0.015129512,
-0.012023277,
0.0018208971,
0.0016577193,
-0.026911788,
0.013723672,
-0.043353416,
-0.0051681343,
0.00028388755,
-0.017526135,
0.018757917,
-0.020552037,
0.02661723,
0.019601421,
-0.017499356,
-0.015062568,
0.017499356,
0.014875122,
-0.0024250734,
0.020217312,
0.036605388,
-0.022654101,
-0.026282508,
0.0023229828,
0.009867655,
-0.013817395,
-0.043969307,
0.010918688,
0.0005857665,
0.019387199,
-0.025947783,
-0.015263402,
0.0016033266,
0.0034510016,
-0.008341315,
-0.033177815,
0.013094393,
0.0056735673,
-0.0062693753,
0.02700551,
-0.016776353,
0.02191771,
0.010363047,
-0.009660127,
-0.016629076,
-0.03058036,
0.013496061,
-0.011681858,
0.014741233,
0.024260776,
0.0041271434,
0.008535455,
-0.0006556401,
0.011681858,
0.020029867,
0.0070158094,
-0.034838047,
0.03730161,
0.0198692,
-0.0010845049,
0.0175663,
0.0053957463,
-0.0026192132,
-0.019440753,
-0.011842526,
-0.031249806,
-0.037381947,
0.028304238,
0.031035583,
0.031142695,
-0.027166178,
0.0036284053,
-0.028464906,
0.024541944,
-0.011373912,
-0.0033288274,
0.012699418,
-0.0027614709,
-0.021114374,
0.012284361,
-0.009318708,
0.01976209,
0.002093697,
-0.0075178947,
-0.0026744425,
0.018503528,
-0.02817035,
0.022493435,
-0.023658274,
0.0082475925,
0.003230084,
0.022573767,
-0.0111663835,
-0.012759669,
0.015250013,
0.00471291,
-0.042657193,
-0.023028992,
0.020203924,
0.008200731,
0.008562233,
-0.0016878444,
0.051547453,
0.007504506,
0.006604099,
-0.014861734,
-0.008562233,
0.020980483,
-0.0022275865,
-0.018677585,
0.043969307,
-0.026563674,
0.007618312,
0.0061053606,
0.025639838,
0.004261033,
0.00011464288,
-0.030419692,
-0.012431639,
0.021636542,
-0.024515165,
-0.019132808,
-0.015183068,
-0.026603842,
-0.010496936,
0.02612184,
0.010450074,
-0.01834286,
0.0003054354,
-0.013763839,
-0.0050007724,
-0.0029120964,
0.0037790309,
-0.0009715356,
0.005455997,
0.00713631,
-0.01656213,
0.003430918,
-0.023926051,
0.04244297,
0.016200628,
-0.001939724,
-0.019199753,
0.013261754,
-0.033017147,
0.006727947,
-0.007966424,
0.02661723,
0.019788867,
-0.0050108144,
0.022587158,
0.017499356,
-0.016548742,
0.0035614604,
-0.01669602,
-0.010798187,
0.00039183596,
0.0024819765,
0.034811266,
0.006520418,
-0.034864824,
-0.020150369,
0.024367888,
0.018208971,
-0.0047898963,
0.03834595,
0.010791493,
0.006235903,
0.014928678,
0.0042811166,
-0.017231578,
0.0029355271,
0.002645991,
-0.0033070704,
0.0013506103,
0.021810599,
-0.01656213,
-0.0016359622,
0.0069086975,
0.026041506,
0.016481796,
-0.011213245,
-0.01038313,
-0.019668367,
0.000033629276,
-0.013549617,
0.0061154026,
0.003430918,
-0.02292188,
-0.0020384674,
-0.0038325866,
-0.028759463,
-0.020284258,
-0.0057639424,
0.009566404,
0.020578815,
0.0038961843,
-0.0005497837,
-0.005653484,
0.016401462,
0.020458315,
-0.029777022,
-0.0023598024,
-0.008495288,
0.021368762,
-0.01286678,
0.020297647,
0.0060149855,
-0.024836501,
-0.0067915446,
0.011065966,
-0.028491683,
-0.013248365,
0.0018125289,
0.011333745,
0.0025355322,
0.009593182,
0.005455997,
0.0028116794,
0.0050677173,
0.010276019,
-0.0051848707,
-0.026081672,
0.034864824,
0.18808796,
-0.0043078945,
0.0070425873,
0.0140048405,
-0.019895978,
-0.015517792,
-0.0063463617,
-0.007919563,
-0.024126885,
0.029268242,
0.016535353,
0.013924507,
0.002558963,
-0.00045480585,
0.0065505435,
-0.00056024385,
0.0050677173,
-0.017887635,
-0.017030744,
-0.013663422,
0.012786446,
0.017887635,
-0.014995623,
-0.0039129206,
0.033579484,
-0.0015497708,
0.0039028786,
0.012424945,
0.010122046,
0.009532932,
-0.017874246,
0.026188785,
-0.010135435,
0.0025137751,
-0.0008301148,
0.0021489263,
-0.0030844791,
0.01871775,
-0.0016183893,
0.0053990935,
0.002940548,
-0.0064434316,
0.014219064,
-0.012538751,
-0.015959628,
0.010751327,
0.00051840337,
-0.023243215,
-0.016548742,
0.0071898657,
-0.033097483,
-0.0036384468,
0.010021629,
0.009057624,
0.019480921,
0.0033204593,
0.035561047,
0.011240023,
-0.0007740486,
-0.006644266,
-0.0038392812,
-0.0035748493,
-0.029884133,
0.013790618,
-0.008836706,
0.030982029,
-0.030794583,
-0.0046760906,
-0.004481951,
-0.0023497606,
-0.0059413463,
-0.025157835,
-0.010048406,
0.0029556104,
0.0062425975,
0.005050981,
0.00038346788,
-0.0051815235,
0.007979814,
0.023859108,
0.00021819802,
0.0022326072,
-0.03108914,
0.010242546,
-0.013087697,
-0.040220402,
0.020110201,
0.0047731604,
-0.020846594,
0.01337556,
0.016388074,
-0.001698723,
-0.028679129,
-0.023296772,
0.016722796,
-0.009492765,
0.0146207325,
0.014808178,
0.0010468485,
-0.011092745,
-0.027474124,
0.074281886,
-0.0094994595,
-0.012083527,
-0.022613935,
0.01298728,
-0.008508678,
-0.005616664,
0.013589784,
0.0006171469,
-0.006861836,
-0.0004292832,
0.016669242,
-0.026804676,
-0.013857562,
0.024260776,
0.008167259,
0.00258072,
0.00834801,
-0.021676708,
0.008073537,
-0.01018899,
0.011896081,
0.0018443278,
-0.007029198,
0.0029589578,
-0.040943407,
0.010677687,
-0.017526135,
-0.04383542,
-0.00586436,
-0.03467738,
-0.0051313145,
-0.0051380093,
0.0028987075,
-0.004120449,
0.0071028373,
-0.016923632,
-0.0028702558,
0.01861064,
-0.009071013,
0.0013154643,
0.013670117,
0.0069890316,
0.017178021,
-0.012250888,
0.0175663,
0.029134354,
-0.023992997,
-0.0038191976,
-0.0033639735,
-0.0039330036,
-0.0041940883,
-0.014754622,
0.012244194,
-0.026831454,
-0.025800506,
-0.030151913,
0.017901026,
0.0061689583,
-0.023403883,
0.02154282,
0.009961378,
-0.0034074876,
-0.006399918,
-0.008455121,
-0.16945054,
0.0033689942,
0.019775478,
0.0010752999,
0.02064576,
-0.014419898,
0.012384778,
0.025840672,
-0.0070425873,
0.0056066224,
0.04865544,
-0.011949637,
0.0016619033,
-0.022466656,
0.007363922,
-0.020056646,
-0.045656316,
0.04777177,
0.0056032753,
0.008495288,
0.022828158,
-0.040113293,
0.0012535404,
-0.051413566,
-0.015316958,
0.019521087,
0.029000463,
0.0012560508,
0.0028116794,
-0.01937381,
-0.027286679,
-0.0075446726,
0.026858231,
0.006968948,
-0.00923168,
-0.0037422113,
-0.019775478,
0.008562233,
-0.005502858,
0.022533601,
0.018208971,
0.00522169,
0.002356455,
0.012023277,
-0.04088985,
0.00719656,
0.008729595,
-0.0006502008,
0.024635667,
-0.014286009,
-0.022011433,
-0.00038284026,
-0.007504506,
0.018302694,
0.014419898,
0.012264278,
0.0026476646,
-0.004157269,
-0.0032769453,
-0.002962305,
-0.021823987,
-0.018557083,
0.03987229,
0.0014886837,
0.020806426,
-0.024742778,
0.014085175,
0.0013087698,
-0.011762192,
0.01594624,
-0.023176271,
-0.013924507,
-0.017860858,
-0.016334519,
0.015089345,
0.0017255008,
-0.00662753,
0.0032267368,
-0.02511767,
-0.0068082805,
0.00283511,
0.012190638,
-0.000090270805,
-0.025880838,
-0.012451722,
-0.00436145,
0.0122776665,
-0.007069365,
0.017164633,
-0.011762192,
0.004558937,
-0.038560174,
0.0035380297,
-0.012993976,
-0.001281155,
0.016937021,
0.000100887824,
0.012578918,
-0.019802256,
-0.004401617,
0.00445852,
-0.01605335,
-0.017539524,
-0.0004773997,
-0.02817035,
-0.005218343,
-0.024300942,
-0.019280087,
0.03017869,
0.003835934,
-0.00598486,
0.0075245895,
0.023082549,
0.031758588,
-0.021100983,
0.012846696,
-0.010101962,
0.00037949302,
-0.014473454,
-0.030767806,
0.058536485,
-0.0014752948,
-0.010476853,
0.0014635795,
0.010845048,
-0.023323549,
-0.124785006,
-0.012585612,
-0.0052384264,
0.0020300995,
-0.012344611,
0.028625574,
0.0019413977,
-0.0027313456,
-0.03722128,
0.00058827695,
-0.015142902,
-0.026858231,
-0.017606469,
-0.01668263,
0.016401462,
0.015718626,
0.023028992,
-0.032428034,
-0.016843298,
0.016789742,
0.0034576962,
-0.026108451,
0.0029254854,
0.0014945414,
-0.0023949482,
0.0034543488,
-0.019695144,
0.008147175,
-0.0028769504,
0.033338483,
-0.0088835675,
0.003181549,
-0.0051748287,
-0.0036350996,
-0.012578918,
-0.016776353,
-0.007397394,
-0.011809053,
0.028384572,
-0.022895103,
0.0135697,
0.0045388537,
0.013763839,
0.021877542,
-0.012023277,
0.006363098,
-0.01388434,
0.019949535,
0.027982904,
-0.0175663,
-0.004585715,
-0.035320047,
-0.017084299,
0.003322133,
0.032910038,
-0.0073170606,
0.022881715,
0.025532726,
-0.021141151,
0.017432412,
0.014339564,
0.009452598,
-0.024059942,
0.01594624,
0.0061990833,
-0.037756838,
0.015611514,
-0.0032903343,
0.03478449,
-0.0139646735,
-0.009352181,
-0.005958082,
-0.012605696,
-0.007604923,
0.00027635627,
-0.0044752564,
-0.009881045,
-0.020672537,
-0.004445131,
-0.009747155,
0.0038426283,
-0.0068350583,
0.012699418,
-0.028946908,
0.021623153,
0.017914414,
0.004063546,
-0.0066107935,
-0.0033455635,
0.0006719579,
0.0014100237,
0.0012711134,
0.002540553,
-0.0069354754,
0.0023196354,
-0.016923632,
-0.008950513,
-0.009137957,
-0.01579896,
0.015357125,
0.000912959,
0.012404861,
-0.036632165,
0.008568928,
0.0034342655,
-0.0069488646,
0.011822442,
-0.012284361,
0.02636284,
-0.00955971,
0.004150574,
0.017820692,
-0.049592666,
0.022908492,
-0.0065471963,
0.01644163,
-0.03108914,
0.00078618235,
0.019266699,
0.019012308,
0.017512746,
-0.016602296,
-0.010028323,
0.0040133377,
0.009064319,
0.014165509,
0.005332149,
0.008642566,
0.0047028684,
0.031062363,
0.003765642,
0.0037120862,
-0.0015740383,
-0.02651012,
-0.013529533,
0.010108656,
-0.025746949,
-0.0071898657,
0.0022928575,
0.034222152,
0.0031547712,
0.029348576,
-0.018838251,
-0.030687472,
0.001079484,
-0.010791493,
-0.0015162985,
-0.002413358,
-0.044504866,
0.031249806,
-0.009579793,
-0.010664298,
0.012565529,
0.0060752355,
-0.012150471,
-0.036739275,
-0.03323137,
0.013134559,
0.012491889,
0.0077388124,
-0.026670787,
-0.03336526,
0.018998919,
0.018838251,
0.012706113,
-0.006463515,
0.018757917,
-0.02393944,
-0.033713374,
-0.012076832,
0.012096915,
-0.020926928,
-0.037007056,
0.0047363406,
-0.01861064,
0.02395283,
0.005218343,
-0.006995726,
-0.008950513,
-0.0016183893,
-0.000612126,
0.010911994,
0.014232453,
-0.005623359,
-0.019440753,
0.0063430145,
0.023738606,
-0.016535353,
-0.02027087,
0.01579896,
-0.0054760803,
0.0037890726,
0.0025388794,
0.008983985,
-0.0051681343,
-0.007129615,
0.009198208,
0.03183892,
-0.0033991195,
0.011059272,
0.0016167156,
0.046647098,
0.0048434525,
0.028705906,
0.0022175447,
-0.01427262,
0.0030058192,
0.0052819406,
-0.01319481,
-0.023444049,
-0.030125136,
0.017124467,
0.025813894,
0.015370513,
-0.013683506,
0.006423348,
-0.025666615,
0.012036665,
0.004512076,
-0.012404861,
-0.014968845,
0.0007727934,
0.008046758,
0.00063932233,
-0.01885164,
0.008957207,
0.0041137547,
0.010958855,
0.01745919,
-0.02088676,
0.003681961,
0.009800711,
0.037569392,
-0.016910242,
-0.0082877595,
-0.013342088,
-0.023805551,
-0.033552706,
0.023390494,
0.018557083,
-0.0017740357,
0.07406767,
-0.004528812,
0.004625882,
0.012813224,
-0.020926928,
-0.012083527,
0.0006401591,
0.0034677377,
0.020351203,
-0.011494413,
0.021931099,
-0.0039999485,
0.036712497,
-0.028652351,
-0.021823987,
0.012130388,
0.0006133812,
-0.0016351254,
0.0018108553,
-0.010704465,
0.0134893665,
-0.0025204697,
0.0019095988,
0.0042275605,
-0.021194706,
-0.013576394,
0.031276584,
-0.011333745,
-0.00032112558,
-0.041371852,
-0.017365467,
0.022895103,
-0.034248933,
-0.013214893,
-0.0014267599,
0.018008137,
-0.013114476,
-0.0073438385,
0.0146608995,
0.0029020547,
-0.009773932,
0.031035583,
-0.03058036,
-0.027822236,
-0.019668367,
-0.0007091959,
-0.016870076,
-0.018195583,
-0.006861836
] |
A solid tumor is an organ composed of cancer and host cells embedded in an extracellular matrix and nourished by blood vessels. A prerequisite to understanding tumor pathophysiology is the ability to distinguish and monitor each component in dynamic studies. Standard fluorophores hamper simultaneous intravital imaging of these components. Here, we used multiphoton microscopy techniques and transgenic mice that expressed green fluorescent protein, and combined them with the use of quantum dot preparations. We show that these fluorescent semiconductor nanocrystals can be customized to concurrently image and differentiate tumor vessels from both the perivascular cells and the matrix. Moreover, we used them to measure | [
-0.020772312,
0.0012124334,
0.009283493,
-0.012901811,
-0.014446858,
-0.00095987757,
-0.033594888,
-0.015674973,
-0.040567413,
-0.0019048989,
0.019042386,
0.0063749733,
-0.0061603836,
0.009547604,
-0.017272843,
-0.0076460065,
0.04952077,
-0.021538233,
-0.025169756,
-0.023717146,
-0.04669478,
0.024126519,
-0.0042951014,
0.010716294,
-0.011884985,
0.016757827,
0.012822578,
-0.041597445,
-0.0051039406,
-0.0026526626,
-0.013826198,
0.0073356763,
-0.025737593,
-0.0037206605,
-0.007084771,
0.017008733,
0.013311182,
0.0059623006,
0.0018141108,
-0.015978701,
0.00493557,
-0.01731246,
-0.0046549523,
-0.013971459,
-0.0248,
-0.0038461129,
-0.019082002,
-0.008715655,
-0.03042556,
0.008114804,
0.014961875,
0.022739938,
-0.00472098,
-0.017827477,
-0.025460277,
0.0025057509,
0.011006816,
0.021974016,
0.009976784,
-0.038929928,
-0.010828542,
-0.004810117,
-0.029369118,
0.025988499,
-0.011799148,
-0.00078944355,
-0.00074363686,
0.014803409,
-0.0011860224,
-0.0010523163,
0.01988754,
0.026080938,
-0.005321832,
0.012056656,
0.0058830674,
-0.016995527,
-0.040593825,
-0.0032105965,
-0.00120418,
0.010854952,
0.005136954,
-0.03206305,
-0.001356869,
0.027203409,
0.010042812,
0.026212994,
-0.0011934505,
0.008326092,
0.018633014,
-0.00051873,
0.008187434,
0.034756977,
0.0045261984,
0.003974867,
-0.0076724174,
0.02181555,
-0.0011901491,
0.035021085,
0.027837275,
-0.038903516,
0.007117785,
0.01654654,
-0.016467307,
-0.027890097,
-0.020376146,
-0.008286475,
0.021643877,
0.016625773,
0.024100106,
-0.014724175,
-0.0164541,
0.018580193,
-0.011634079,
-0.03652652,
0.015661769,
0.009283493,
0.04812098,
-0.0077384454,
0.0045030885,
0.0023423324,
0.0135356765,
0.004542705,
0.021775933,
-0.022396592,
0.03747732,
-0.0045625134,
0.001394835,
-0.01010884,
-0.010828542,
-0.011977423,
-0.00267082,
0.013628115,
-0.001936262,
0.020046007,
-0.012611289,
-0.0060481364,
-0.024205752,
0.013047072,
-0.037847072,
-0.032564856,
0.0011084399,
0.019570608,
0.0016391374,
-0.011442599,
0.0043182108,
0.027203409,
0.011944409,
0.029474761,
0.013522471,
0.007223429,
0.0078440895,
-0.018936742,
0.00672492,
-0.0025007988,
0.007982748,
0.016110757,
-0.0052492013,
0.034281578,
-0.0008550586,
0.005810437,
0.007698829,
0.0074215126,
0.020547817,
0.015595741,
0.013212141,
0.020587433,
0.012215123,
0.004645048,
-0.017206816,
-0.0012644302,
0.00069576676,
0.028576784,
-0.015001492,
0.02491885,
-0.013198935,
0.017114377,
-0.0077384454,
0.023268158,
-0.040567413,
-0.021379767,
-0.011951012,
0.013562088,
0.0037041535,
-0.0036777423,
0.0030554314,
0.00051501597,
0.037186794,
-0.016084345,
0.012631097,
-0.008610011,
-0.01766901,
0.022330565,
0.009488179,
-0.016995527,
-0.656685,
-0.0047440897,
0.028259851,
-0.02820703,
-0.011449202,
0.023228541,
0.0062726308,
-0.0248,
-0.032961022,
-0.00047251067,
-0.014763792,
0.018355697,
0.0112841325,
-0.0061504794,
-0.0043215123,
-0.026318638,
-0.015516507,
-0.0006124068,
0.0043677315,
0.019544197,
-0.008458147,
-0.0010118744,
-0.015701385,
0.019715868,
0.023334187,
0.02649031,
0.029157829,
-0.0016746273,
0.0070979767,
0.033832587,
-0.041676678,
0.03016145,
-0.015173163,
0.009078807,
0.046483494,
-0.0033971246,
-0.022792758,
0.021762727,
0.020943983,
0.028391907,
0.012505645,
-0.016348457,
0.03145559,
-0.023215337,
-0.049124602,
0.014367625,
-0.008610011,
-0.01344984,
-0.003261768,
-0.0010234292,
0.0017035144,
-0.017233226,
-0.03560213,
-0.005992013,
0.0050610225,
-0.01790671,
0.031217892,
-0.00061364484,
-0.008676038,
0.0017035144,
0.013945049,
-0.0056618745,
-0.0074281152,
-0.0122745475,
-0.0066159745,
0.026014911,
-0.024747178,
0.021525027,
0.0153844515,
0.010003195,
0.023505857,
0.02367753,
-0.017418105,
-0.0050115017,
0.012584878,
0.06898573,
0.02060064,
0.0014509585,
0.009032588,
0.00080388715,
0.010161662,
-0.018236848,
-0.037266027,
0.0063122474,
0.008742066,
0.007778062,
-0.039061982,
0.009177849,
0.008755271,
0.00091118214,
0.0033426518,
0.01683706,
-0.024126519,
-0.053667307,
-0.01659936,
0.021419384,
0.00041432376,
0.015344835,
0.020917572,
-0.0076460065,
-0.02870884,
-0.008616613,
0.015542919,
-0.006239617,
0.018540576,
0.016876677,
-0.032089457,
0.0070187435,
0.021036422,
-0.05276933,
0.004146539,
-0.013113099,
-0.0053614485,
-0.0039880727,
-0.0028656018,
-0.021947604,
0.013390415,
0.021326944,
0.005239297,
-0.01633525,
0.024324602,
-0.0029580405,
0.0068470715,
-0.0054043666,
0.037081152,
-0.004007881,
0.00426869,
-0.029633228,
-0.023254953,
-0.00038894438,
-0.011700107,
-0.011581257,
0.023162514,
-0.010386156,
0.009864537,
-0.009032588,
-0.0151863685,
0.0034697552,
-0.0043512248,
-0.030636849,
-0.012611289,
-0.027916508,
0.016493717,
0.0011414537,
-0.015925879,
-0.0039352505,
-0.03018786,
-0.006715016,
0.002134345,
-0.0047870073,
-0.013628115,
-0.002601491,
-0.0007324947,
-0.00022449414,
0.023968052,
-0.0068668798,
0.0011464058,
-0.015595741,
0.0020468584,
0.000062571555,
-0.00030682242,
0.007381896,
-0.002708786,
0.012934824,
-0.00074322417,
-0.032776147,
-0.02684686,
0.005143557,
0.009474973,
-0.024205752,
0.004843131,
-0.010174867,
-0.007857295,
0.021432588,
-0.0050940365,
0.0011678648,
0.010769117,
-0.026226198,
0.0025899361,
-0.01826326,
0.009904154,
-0.016876677,
-0.0058005326,
-0.0030504793,
0.028312674,
0.027520342,
0.016506923,
0.020283706,
-0.004453568,
0.004275293,
0.01135016,
0.01018147,
-0.020323323,
0.013047072,
-0.004516294,
-0.016256018,
0.011931203,
0.0063122474,
0.00128754,
0.031482004,
-0.0015929181,
-0.013575293,
0.0141299255,
0.00827327,
0.013106497,
-0.015133547,
-0.0018982961,
-0.022660704,
0.0050181043,
0.016216401,
0.0128754,
0.004876145,
-0.011944409,
-0.0014451811,
0.010445581,
0.019412141,
0.0019560703,
-0.025143344,
-0.021128861,
-0.017035143,
-0.020296913,
-0.016282428,
0.008788286,
-0.015661769,
0.010293717,
0.0049817893,
0.0141959535,
0.0059061768,
-0.010861555,
-0.01828967,
-0.005252503,
0.01861981,
0.0075535676,
0.005133653,
0.0035588925,
-0.0058236425,
0.008821299,
-0.006051438,
0.044344198,
0.009772099,
-0.0058269436,
0.028312674,
0.0013964856,
0.0028523963,
0.0029910544,
-0.013694143,
0.029184239,
0.0018652823,
-0.0087684775,
-0.012789563,
0.004800213,
-0.003641427,
-0.009679659,
0.0031280618,
-0.0024281684,
-0.0014715921,
0.015252396,
0.006424494,
0.04875485,
-0.0029695954,
0.025486689,
-0.0076460065,
-0.004575719,
-0.0207459,
-0.0077516506,
0.02391523,
0.015648562,
-0.019412141,
-0.00588967,
0.024879234,
-0.0073092654,
0.000112143905,
0.009818317,
-0.021155272,
0.018778276,
0.021683494,
0.007685623,
0.022766348,
0.006807455,
-0.0028556976,
-0.029421939,
-0.030874548,
0.011845368,
0.026331844,
-0.004347923,
-0.032828968,
-0.020310117,
-0.0009615282,
0.008088392,
-0.0019610224,
0.022290949,
-0.016374867,
0.0011934505,
-0.0027418,
-0.011006816,
-0.0015698083,
0.014380831,
-0.0038923323,
0.01633525,
0.004093717,
0.007665815,
-0.02894654,
-0.019795101,
-0.012538658,
0.013826198,
0.012426412,
-0.008682641,
-0.0027632588,
0.017801065,
-0.0139318425,
-0.033647712,
-0.009032588,
-0.006087753,
-0.027414696,
0.0028837593,
0.012604686,
0.0028656018,
0.024813207,
0.036843453,
-0.00653344,
0.0070781684,
-0.024364218,
0.00987114,
-0.022753142,
0.013522471,
0.020310117,
0.0045030885,
0.0059556975,
-0.011713312,
-0.016440894,
-0.0073620877,
-0.0085703945,
0.023664324,
-0.018976359,
0.0075997873,
0.0034961663,
0.016467307,
0.0122745475,
-0.0060250266,
0.021208094,
-0.011475612,
-0.005622258,
-0.007652609,
0.009283493,
0.0017183706,
-0.026477104,
0.030346327,
0.0075865816,
0.02382279,
-0.016559744,
-0.014050692,
0.009818317,
0.0015227636,
0.0006994808,
-0.0143940365,
0.025262194,
-0.006576358,
0.00827327,
-0.0094947815,
-0.015727796,
0.020494996,
0.0137997875,
-0.003974867,
0.007698829,
-0.000301045,
0.018157614,
0.0077582537,
-0.000015758953,
-0.012459425,
-0.01259148,
0.008431736,
-0.01275655,
-0.0060811504,
-0.0055958466,
0.026939297,
-0.00022862088,
-0.008623216,
-0.031138659,
-0.0046912674,
-0.014050692,
0.003416933,
-0.022383386,
-0.009019382,
-0.008913739,
0.008517572,
-0.018038765,
0.017404899,
-0.019412141,
-0.023030458,
0.0018058573,
-0.012433014,
-0.0020798722,
-0.023849202,
-0.00028103037,
0.008068584,
-0.018514164,
-0.026384665,
-0.013812993,
0.014961875,
-0.000107914006,
0.008187434,
0.005546326,
-0.00020716188,
0.010465389,
-0.009191055,
-0.0025074016,
-0.000119365686,
-0.04495165,
-0.010366348,
-0.020283706,
0.0031148563,
-0.029474761,
-0.00827327,
0.010498403,
0.0076460065,
-0.018157614,
-0.004446965,
0.016348457,
-0.016295634,
0.01361491,
0.0061372737,
0.0106238555,
-0.005797231,
-0.006398083,
-0.003760277,
-0.033277955,
-0.0051138448,
-0.026107349,
-0.0047870073,
-0.0219344,
-0.0053878594,
0.0062990417,
-0.016018318,
-0.021459,
0.0069989352,
-0.004496486,
-0.013383813,
-0.018699042,
0.01962343,
0.01208967,
-0.0212213,
0.018250054,
-0.008147817,
0.008590203,
-0.016176784,
0.00087899365,
0.029157829,
-0.02565836,
-0.0139978705,
0.005635463,
0.013231949,
-0.002446326,
-0.009111822,
-0.022660704,
0.009659851,
0.04566475,
-0.009739084,
-0.019636635,
0.00022635117,
-0.011237913,
-0.0032006924,
0.0026576146,
-0.013667732,
0.0013783281,
-0.010656869,
0.04421214,
0.025697976,
-0.024615124,
0.0073356763,
-0.039114803,
-0.024073696,
0.011059638,
0.02565836,
0.018487753,
-0.008629819,
-0.010815335,
-0.020811928,
-0.00994377,
-0.010881363,
-0.01583344,
-0.024971673,
-0.003829606,
0.039854314,
0.007091374,
0.02429819,
0.01864622,
0.033013847,
0.013720554,
0.0011554846,
0.012036848,
-0.015001492,
0.003459851,
-0.0043050055,
0.03068967,
0.007923323,
0.014539298,
0.0135356765,
-0.02823344,
0.02894654,
0.0108879665,
-0.0071375933,
0.006688605,
-0.013918637,
-0.028259851,
-0.024720768,
0.015107135,
-0.005476997,
0.012096273,
-0.030636849,
-0.010056017,
0.007890309,
0.0060250266,
0.012155698,
-0.0070649628,
0.021392971,
-0.019610224,
0.0005121273,
-0.016440894,
0.0034961663,
0.00084350375,
-0.0040904153,
-0.0059391907,
-0.013515868,
-0.006493823,
0.008028967,
0.00031734558,
0.029369118,
0.00577082,
-0.003829606,
-0.014143132,
-0.010280511,
-0.015741002,
-0.0017068158,
-0.033542067,
-0.021392971,
-0.0062726308,
-0.021947604,
-0.02024409,
-0.007461129,
-0.00087734294,
-0.02477359,
0.0048728436,
-0.0050115017,
-0.005856656,
0.02293802,
-0.010551225,
0.020019596,
-0.028101385,
0.020310117,
0.01695591,
-0.017867094,
-0.03092737,
-0.010637061,
-0.026463898,
0.008576997,
0.033251546,
0.010828542,
-0.016348457,
0.00015629992,
0.035919063,
0.012287754,
-0.0012413206,
-0.025328223,
0.013218744,
0.007850693,
0.000578155,
-0.029316295,
-0.0132055385,
-0.039114803,
-0.0076460065,
-0.0100164,
0.012967838,
-0.0013453142,
-0.0034796593,
-0.019821513,
0.015503301,
-0.028814483,
0.024945261,
-0.012974441,
-0.02379638,
-0.002601491,
-0.016731417,
-0.01864622,
0.0021954207,
0.012234931,
0.013654526,
-0.0036513312,
-0.004876145,
0.034070287,
0.013522471,
0.001053967,
-0.007943131,
0.0021640575,
0.043604687,
-0.0013684239,
0.00094419596,
0.033013847,
0.028418317,
0.012809372,
-0.003717359,
-0.00081296597,
-0.01111246,
-0.038428117,
-0.005727902,
0.014895847,
0.016559744,
-0.016123962,
0.004182854,
-0.014843025,
-0.01814441,
-0.015767412,
-0.026595954,
0.006153781,
-0.03216869,
-0.030874548,
0.023109691,
0.02849755,
0.03850735,
-0.009857934,
0.0015830139,
-0.007863898,
0.042997234,
-0.014935464,
0.014420448,
0.024403835,
0.02796933,
-0.029818105,
0.0026212994,
0.012901811,
-0.03805836,
0.009600426,
-0.019517785,
-0.037371673,
-0.031244304,
-0.006635783,
0.019042386,
0.009257082,
-0.011627477,
0.021168478,
0.00493557,
0.016995527,
-0.016242811,
0.0039616614,
0.013456443,
-0.014367625,
0.017867094,
-0.007223429,
-0.009745687,
-0.020547817,
0.0038758253,
-0.025447072,
0.010102237,
-0.0022300852,
-0.023228541,
-0.012657508,
0.02625261,
-0.01251885,
0.010676677,
-0.018342493,
-0.036843453,
-0.010240895,
-0.0010622204,
-0.01814441,
-0.022238126,
0.00027793532,
-0.022964431,
0.0025239084,
0.009620234,
-0.03805836,
-0.007203621,
-0.009375932,
-0.020851545,
-0.02379638,
0.013786581,
-0.014843025,
0.029633228,
0.0053614485,
-0.018593397,
-0.0021244409,
0.002563525,
-0.024813207,
-0.03116507,
0.027335463,
0.007434718,
-0.009191055,
0.016916294,
-0.008530778,
0.025552716,
-0.017602982,
0.01707476,
0.0047242814,
-0.011257721,
0.019993184,
-0.0135356765,
0.022871992,
0.0020633654,
-0.020732695,
-0.011653887,
0.025764005,
-0.004361129,
-0.012525453,
0.010174867,
-0.010597444,
0.005982109,
-0.025697976,
0.009745687,
0.0014963525,
0.01962343,
0.016203195,
-0.012419809,
0.004347923,
-0.0036447286,
-0.0016482163,
0.0028540469,
0.0013230299,
0.007685623,
0.01294803,
0.0055265175,
-0.0029761982,
-0.014961875,
0.006642386,
0.0028226837,
0.01330458,
0.023730353,
0.009567413,
0.015820235,
0.01447327,
0.0040970184,
-0.000071856695,
-0.019042386,
-0.02033653,
-0.0077978703,
-0.008194037,
0.003426837,
0.0024776892,
0.0046219383,
0.0045856233,
-0.045294996,
-0.009838126,
0.017352076,
-0.021036422,
-0.02894654,
0.013284772,
-0.0032832269,
0.008933547,
-0.021089245,
-0.009976784,
-0.024139723,
-0.0145921195,
-0.015120341,
0.014895847,
-0.028418317,
0.0018009052,
-0.022660704,
0.000050346112,
0.0034202344,
-0.009930565,
-0.0034829606,
-0.011323749,
0.0006586262,
0.1726228,
-0.005552929,
0.004952077,
0.029765284,
0.0064707138,
0.0151863685,
0.0012132588,
-0.015516507,
0.0083459,
0.014803409,
0.03021427,
0.017140789,
-0.009554206,
-0.0043842387,
0.007639404,
-0.015912673,
-0.019900747,
0.0038064963,
-0.02897295,
-0.021551438,
-0.009745687,
-0.01571459,
0.018804686,
-0.012116081,
0.019847924,
-0.01986113,
0.016229607,
-0.0022003727,
0.008101597,
-0.0039550588,
-0.0077516506,
-0.014539298,
0.01166049,
0.002434771,
0.0075865816,
0.0056453673,
-0.014737381,
-0.0060580405,
0.0076460065,
0.005562833,
0.004869542,
0.015014697,
-0.01879148,
0.013093291,
0.023809586,
0.030240683,
0.0030191161,
-0.0048134187,
0.0027021833,
0.0008484558,
-0.04001278,
0.014882642,
0.01850096,
0.01654654,
-0.020349734,
0.026226198,
0.009455165,
0.006774441,
0.01092098,
0.009019382,
-0.025209373,
0.007632801,
-0.0075865816,
0.03488903,
-0.0031561237,
0.011317146,
-0.017325666,
0.0074941427,
0.013053674,
0.0016011714,
0.0064608096,
-0.0029530884,
-0.010280511,
0.0049091587,
0.023690736,
-0.0077714594,
0.012842386,
0.007949734,
0.012782961,
0.0061009587,
0.010663472,
-0.011257721,
-0.015159958,
0.015793823,
-0.0089665605,
-0.022423003,
0.017735038,
0.0074941427,
0.016467307,
-0.00987114,
-0.0042455806,
0.005196379,
-0.00851097,
0.0009301651,
0.0123471785,
0.008590203,
-0.007236635,
0.011904793,
-0.014961875,
-0.010478594,
-0.026226198,
0.052663688,
0.01361491,
0.002880458,
0.00951459,
0.010894569,
-0.021432588,
0.007315868,
0.0023291267,
-0.0026378063,
0.0028408414,
-0.015556124,
0.009197657,
-0.01826326,
-0.0073884986,
0.03068967,
-0.0048860493,
-0.035443664,
0.026978914,
-0.0010316827,
-0.0031330138,
-0.0143280085,
0.005665176,
-0.0073290737,
0.0055166134,
0.0026675188,
-0.000037114783,
0.008411928,
-0.00901278,
-0.02820703,
-0.0036843452,
-0.0027814165,
-0.011429394,
0.016520128,
0.022634292,
-0.018540576,
-0.011072843,
0.019557402,
-0.037899893,
0.009930565,
-0.016031524,
-0.011884985,
-0.00033302716,
0.024020873,
-0.0046417466,
-0.008365708,
0.011568052,
-0.016638977,
-0.017220022,
-0.033779766,
-0.012261342,
-0.014037487,
0.0032419595,
-0.0065895636,
0.022594675,
-0.029342705,
-0.009818317,
-0.024549095,
0.0071309907,
0.009970182,
-0.020693079,
0.004060703,
0.029976571,
-0.018131204,
0.0009276891,
0.010696486,
-0.16607285,
0.014922258,
0.025605539,
-0.009593823,
0.012116081,
-0.00543738,
-0.0034367412,
0.002730245,
-0.014710969,
0.008676038,
0.025684772,
0.014710969,
-0.037186794,
-0.012848988,
0.00168123,
0.010339936,
0.0044007455,
0.024984878,
0.027784452,
0.015371246,
0.019359319,
-0.011951012,
0.03488903,
-0.01006262,
0.0070979767,
0.014367625,
0.013502663,
0.0110860495,
0.00020994742,
-0.0077516506,
0.0031660278,
-0.020930778,
-0.0028094782,
-0.005004899,
-0.00068256125,
0.006688605,
-0.0049751867,
-0.012538658,
0.0024496273,
0.0074149095,
0.0042488817,
0.014156337,
0.0012718583,
0.004420554,
-0.0017348776,
0.033066668,
-0.007665815,
0.0010911076,
0.038877103,
-0.015437274,
0.059477743,
-0.010009798,
-0.0059094783,
0.022277743,
0.01683706,
-0.004413951,
-0.0048530353,
0.011264324,
0.020296913,
0.010597444,
-0.010854952,
-0.02358509,
-0.015846645,
0.012300959,
-0.013812993,
-0.049388714,
-0.012882003,
-0.018276464,
-0.013548882,
-0.018065177,
-0.051184665,
-0.0060217255,
0.0062561235,
-0.010313525,
0.03116507,
0.0205082,
0.004397444,
-0.018580193,
-0.0136017045,
0.013443238,
-0.009983387,
0.0028986156,
-0.0026130457,
-0.021155272,
-0.0044106496,
-0.009679659,
-0.0060052183,
0.013628115,
-0.010280511,
0.009468371,
0.010042812,
-0.022251332,
0.0032155486,
-0.016757827,
0.0139978705,
0.03974867,
0.006259425,
-0.0036513312,
0.0010712993,
0.0016176784,
0.027441109,
-0.0052690096,
-0.02086475,
0.0120104365,
0.0145260915,
0.012888605,
0.011455804,
0.005803834,
0.06539383,
0.0029761982,
-0.03164047,
-0.0062099043,
-0.00043784612,
0.021894783,
0.0048398296,
0.014803409,
0.020178063,
0.008913739,
0.021049628,
-0.02849755,
0.06349222,
0.0075337593,
-0.009534398,
0.03116507,
0.021683494,
-0.02651672,
-0.1325836,
-0.022607882,
-0.0058962726,
0.01852737,
0.019398935,
0.020970395,
0.0036018104,
0.019583814,
-0.014697764,
0.044317786,
-0.007632801,
-0.030584026,
-0.0071640043,
-0.020455379,
0.005727902,
-0.0020022898,
-0.002858999,
0.004017785,
-0.018751863,
0.026569543,
0.00944196,
0.0036249203,
0.011515229,
-0.011528435,
0.010782322,
0.023598297,
-0.042363368,
0.016057935,
0.005417572,
0.018963153,
0.012974441,
0.0006540868,
0.023241747,
-0.034440044,
-0.00020396366,
0.007850693,
0.0020534613,
-0.017985944,
0.021406177,
-0.008378914,
-0.009507988,
0.009336315,
0.033251546,
0.029184239,
0.01037295,
0.0007890309,
-0.039167628,
0.0029861024,
0.018580193,
-0.017536955,
-0.031191481,
-0.033779766,
-0.020204473,
-0.008761874,
0.017985944,
-0.021379767,
0.019372525,
-0.011409585,
-0.019715868,
0.02086475,
-0.0037371672,
-0.007652609,
-0.013469649,
0.025684772,
0.019082002,
-0.008920341,
-0.019874334,
-0.016652184,
0.0058368477,
-0.030716082,
-0.0022763046,
-0.009963579,
-0.0145921195,
-0.01690309,
-0.012789563,
-0.010670075,
-0.011244516,
0.0062,
0.005724601,
-0.017510543,
-0.013245155,
-0.022871992,
0.02897295,
-0.017880298,
0.025407456,
0.031376358,
-0.005252503,
-0.0022878596,
0.031957403,
-0.015859852,
0.026675187,
0.011766135,
-0.0063749733,
-0.015608946,
-0.0036942493,
0.0066919066,
0.0137337595,
0.012459425,
0.028523963,
0.013416827,
-0.019689457,
-0.02577721,
-0.045030884,
0.00791672,
0.004328115,
0.013357402,
0.0075667733,
-0.015265602,
0.0008059505,
-0.011119063,
0.028339084,
0.022211716,
-0.012426412,
0.011435996,
-0.0038428116,
-0.007441321,
-0.039352503,
-0.021802343,
0.020653462,
-0.0022300852,
0.007005538,
0.04043536,
-0.0055925455,
-0.004473376,
-0.0034334399,
0.032485623,
0.004139936,
0.0041069225,
-0.01197082,
0.022779554,
-0.018817892,
-0.030372737,
0.011931203,
-0.014288392,
-0.0047440897,
0.010590842,
0.006110863,
-0.02391523,
-0.006559851,
0.013971459,
0.010564431,
0.04273312,
-0.0060052183,
-0.04294441,
0.0141959535,
-0.0013510917,
-0.021511821,
0.01633525,
-0.026860064,
-0.0041762516,
-0.0036678382,
0.014737381,
0.034017466,
0.0018834398,
0.00079645903,
-0.02553951,
-0.041174866,
0.002451278,
0.0072630458,
-0.007282854,
-0.01950458,
-0.010987008,
0.032221515,
0.013225347,
-0.019663047,
0.015648562,
0.008643025,
-0.02613376,
-0.032300748,
0.0024232164,
0.011363366,
-0.03016145,
-0.027361875,
-0.008748669,
0.01719361,
0.004998296,
0.006596166,
-0.010115442,
-0.013522471,
-0.012485837,
0.0078440895,
0.042521834,
0.009851332,
0.013291374,
-0.006130671,
0.028022151,
0.02701853,
0.0012033547,
-0.0067876466,
0.04349904,
0.010788925,
-0.0048464327,
-0.011627477,
0.025354633,
0.015014697,
-0.010775719,
0.014843025,
0.0054109693,
-0.003997977,
0.031006603,
0.02391523,
0.03206305,
0.007883706,
-0.0047705006,
0.013562088,
-0.017748244,
-0.011152077,
-0.0027550054,
-0.039431736,
-0.014922258,
-0.020759106,
0.014169542,
0.00908541,
-0.0063122474,
0.015067519,
-0.01099361,
-0.021683494,
0.022423003,
0.0021789137,
-0.0062462194,
0.0016432642,
0.027546752,
0.024073696,
-0.009309905,
0.001957721,
0.0047473907,
0.0145921195,
0.0050610225,
0.015146752,
-0.020693079,
0.033832587,
-0.015318424,
0.0078440895,
-0.0044238553,
-0.021089245,
-0.0072498405,
-0.005539723,
-0.032247923,
0.021591054,
-0.0028144303,
0.0075073484,
0.085783176,
-0.008801491,
-0.009342918,
0.01802556,
-0.027441109,
0.007712034,
0.020983601,
0.016361661,
-0.013443238,
-0.022541853,
0.025103727,
-0.0050247074,
0.00013731697,
-0.010934185,
-0.029395528,
0.0340967,
-0.02524899,
0.0123471785,
-0.010709692,
0.016123962,
0.021049628,
-0.021472204,
-0.003512673,
0.028259851,
-0.024443451,
-0.0038857297,
0.021287328,
0.003250213,
0.007573376,
-0.008827902,
0.0061735893,
-0.0047936104,
-0.036975507,
-0.015358041,
0.017748244,
-0.0024397231,
-0.011092652,
-0.03533802,
-0.0061867945,
0.031033015,
0.017801065,
0.04098999,
-0.012512247,
-0.015397658,
-0.024984878,
-0.004882748,
-0.029474761,
-0.028365497,
0.008088392
] |
Because arginase hydrolyzes arginine to produce ornithine and urea, it has the potential to regulate nitric oxide (NO) and polyamine synthesis. We tested whether expression of the cytosolic isoform of arginase (arginase I) was limiting for NO or polyamine production by activated RAW 264.7 macrophage cells. RAW 264.7 cells, stably transfected to overexpress arginase I or beta-galactosidase, were treated with interferon-gamma to induce type 2 NO synthase or with lipopolysaccharide or 8 | [
-0.024003686,
-0.029206913,
0.0027952446,
-0.021925045,
-0.01494769,
0.017807478,
-0.01718521,
0.013676673,
-0.020852624,
-0.024202283,
0.016457023,
-0.0083940085,
0.013703153,
-0.0032933906,
-0.025711617,
-0.0016938619,
0.02886268,
-0.0122335395,
0.025817534,
0.009506148,
-0.02441412,
0.020812904,
-0.01383555,
-0.028783241,
0.0061962083,
0.029048037,
0.00556401,
-0.033152364,
-0.010929423,
-0.03392027,
0.0134582175,
-0.009307552,
0.0024559756,
-0.008407248,
-0.00035188804,
-0.0133192,
0.011353095,
0.013756112,
0.01989936,
-0.009287693,
0.022573793,
-0.011326616,
-0.0076724417,
-0.0022904787,
-0.008400628,
-0.008758103,
0.010691107,
0.0007596313,
-0.012246779,
0.018363548,
0.031245837,
-0.018045794,
-0.005782466,
-0.005365413,
-0.018694542,
0.00834767,
0.002887923,
0.008288091,
-0.016708579,
-0.0079835765,
-0.0006917775,
0.011770148,
-0.026889956,
0.03595919,
-0.02324902,
0.013689913,
0.0024708705,
0.004048057,
-0.0050642085,
-0.00945319,
0.021223338,
0.0040877764,
-0.03993112,
0.0031907824,
0.0051337173,
-0.030133696,
-0.035297204,
0.0024725255,
-0.0016649,
-0.0026860165,
0.036833014,
-0.0030981041,
-0.019277092,
0.014298942,
0.036700618,
-0.016020112,
0.017317608,
0.022507595,
0.010254195,
-0.011180978,
0.041387495,
0.023235781,
0.03717725,
0.012637353,
-0.01220044,
0.0049020215,
-0.0036343145,
0.016205467,
-0.013001446,
-0.00389249,
-0.02497019,
-0.0034290983,
-0.017092532,
-0.011684089,
-0.023990447,
0.00609691,
-0.014140065,
-0.013994427,
0.030027779,
0.0033579345,
-0.02267971,
0.029683545,
0.0091288155,
-0.043082185,
0.0278035,
-0.00886402,
0.051317316,
0.013623714,
-0.025407102,
-0.010174757,
-0.0020869174,
0.0059711323,
0.036382865,
-0.022666471,
0.035270724,
0.0141930245,
-0.0021316016,
-0.0037534724,
-0.022494355,
-0.012478475,
0.024625955,
0.025234984,
0.011280277,
0.013597235,
-0.012260019,
0.015914192,
-0.029233392,
-0.0006301299,
0.00022238662,
-0.02445384,
0.0046802554,
0.03222558,
-0.031881344,
0.013166943,
-0.009651786,
0.031245837,
0.036938936,
0.001470441,
0.0029640517,
0.0036806536,
-0.0076327226,
-0.021726448,
0.031298798,
-0.035376642,
0.018800462,
0.016457023,
-0.009843763,
0.02662516,
-0.033072922,
0.00023769509,
0.014285702,
-0.014298942,
0.014762334,
-0.0072818687,
-0.001113795,
0.01711901,
0.017847199,
0.0053190743,
-0.003981858,
-0.013636954,
0.0008936839,
0.021792646,
-0.013074264,
0.029048037,
0.0027935896,
0.021686729,
0.024321442,
0.019581607,
0.0062888865,
0.007818079,
0.003263601,
0.014259223,
0.021435173,
-0.0015995287,
-0.011174358,
-0.010393213,
0.03100752,
0.0035151567,
0.018350309,
-0.010366733,
-0.02381833,
0.005924793,
-0.014378381,
-0.03664766,
-0.63550854,
-0.03397323,
0.009340651,
-0.011670849,
0.003766712,
0.027829979,
0.0039619985,
-0.017317608,
-0.014391621,
0.049013596,
-0.033628993,
0.0110485805,
0.009519388,
-0.029736504,
-0.004114256,
-0.03503241,
0.011922405,
-0.013120604,
0.0064808633,
-0.010618289,
-0.023963967,
-0.011730429,
0.007156091,
0.0034853672,
0.005600419,
0.041122697,
0.054600775,
-0.008572745,
-0.026916435,
0.01500065,
0.034688175,
0.005848665,
0.00027534566,
-0.015450802,
0.056348424,
0.0006673667,
-0.0070898924,
0.023341699,
-0.0020951922,
0.017979596,
-0.013246382,
-0.009797423,
0.0266384,
-0.016721819,
-0.000914371,
0.018760743,
0.0064610033,
0.013292721,
0.0048358226,
-0.021223338,
-0.009466429,
0.0062955064,
-0.00011036582,
0.0059645125,
0.0110552,
0.020084718,
0.020852624,
-0.04064607,
0.019714005,
-0.0016309731,
-0.019383011,
0.018734261,
-0.037071332,
-0.015940672,
0.010863224,
0.005812255,
-0.01000264,
-0.0016549701,
0.007467225,
0.03625047,
0.0244406,
0.017913397,
-0.02274591,
-0.0015109878,
0.009598827,
0.038554184,
-0.00221435,
0.007374547,
-0.018231152,
0.019766964,
0.014510779,
0.007275249,
-0.021739688,
0.010101938,
0.03723021,
-0.016457023,
-0.0155434795,
0.028942117,
0.0066695297,
-0.0030699696,
0.02666488,
0.016735058,
-0.02162053,
-0.011333236,
-0.015927432,
0.005259495,
0.007698921,
0.0061895885,
-0.010207856,
-0.014245983,
-0.021143898,
-0.018707782,
-0.00084279355,
0.0015995287,
0.0054084426,
-0.0069972137,
-0.041943565,
-0.021567572,
0.041281577,
-0.024811313,
0.01711901,
0.010062219,
-0.01715873,
-0.026982633,
-0.0017873677,
-0.0199126,
-0.007328208,
-0.008182173,
0.0023467478,
-0.019541888,
-0.013398638,
-0.016311387,
0.007970336,
-0.0043194722,
0.018946098,
0.017873678,
-0.0031427883,
-0.022759149,
-0.030742725,
-0.014881492,
0.00721567,
0.0028432386,
0.03828939,
-0.02212364,
0.04326754,
0.024493558,
0.045862533,
0.011379574,
0.013418498,
-0.021461653,
-0.014245983,
-0.003604525,
-0.014166544,
0.0037965016,
-0.009188394,
0.01051899,
-0.020627549,
0.0041440455,
0.018006075,
0.00074142666,
-0.010174757,
0.0048490628,
-0.018111993,
0.020203875,
0.01274989,
0.00061606267,
-0.021355735,
-0.012663832,
0.012961727,
0.014722615,
0.012094522,
0.006398115,
-0.008658804,
-0.0030583849,
-0.021885326,
-0.009631926,
0.0030219755,
0.008969938,
-0.009744464,
-0.025115827,
0.0046272967,
0.0124387555,
-0.0210777,
0.0064643133,
0.015358123,
0.0014936106,
-0.017794238,
0.025896974,
-0.015675878,
0.0022375197,
-0.009585587,
0.004044747,
-0.011670849,
-0.020892343,
0.001578014,
0.029286353,
0.0018701163,
0.010082078,
-0.0013148738,
0.03437042,
0.0016748297,
0.015755316,
-0.019872881,
0.0030120458,
-0.0056699277,
-0.03222558,
0.011333236,
-0.00079976436,
0.0054117525,
0.038527705,
0.020455431,
-0.010432932,
-0.009406851,
-0.014245983,
-0.00498808,
-0.0132132815,
0.0015490521,
0.0016557977,
0.012451995,
-0.001026909,
0.0018552216,
-0.004104326,
0.0006044778,
0.008579365,
0.007175951,
0.0035813553,
-0.012445375,
-0.009009657,
0.013166943,
-0.009380371,
-0.0016574527,
-0.002661192,
0.0012304704,
-0.0047927937,
-0.03482057,
-0.0036773437,
-0.00041746622,
0.0072289095,
-0.015808275,
-0.01390175,
-0.029471708,
-0.009539248,
-0.009929821,
-0.010962523,
0.007599623,
0.01497417,
0.005398513,
0.0012677071,
0.032861087,
0.0052892845,
-0.021991244,
-0.019727245,
0.0058023254,
0.010260815,
0.024069887,
-0.0010343563,
0.03950745,
0.01714549,
-0.028147733,
0.0048391325,
0.0020670576,
0.020733466,
-0.00834105,
-0.0020836075,
-0.00056930975,
0.02282535,
0.02324902,
0.008182173,
0.043479376,
0.0072818687,
0.010426312,
-0.0009317482,
-0.0005436577,
-0.0079438565,
-0.015252205,
0.0063881846,
0.017330848,
0.0018866659,
-0.008354289,
0.009102336,
-0.04046071,
0.004484969,
0.027485745,
0.0075069447,
0.002374882,
0.012869048,
-0.007109752,
0.002988876,
0.03823643,
-0.0055110506,
-0.026585441,
-0.02719447,
0.040566627,
-0.009102336,
-0.0076393425,
-0.019766964,
-0.013729633,
0.0013405258,
0.0004205693,
0.019210894,
-0.008016676,
-0.0015838065,
0.010485891,
0.011366335,
-0.015900953,
-0.009069237,
0.01053885,
-0.028094774,
0.025261465,
-0.015318404,
0.0051337173,
-0.0037733319,
-0.014166544,
0.00887726,
0.04437968,
0.02941875,
0.005203226,
0.0057063373,
-0.003381104,
-0.028942117,
0.0137428725,
0.014140065,
-0.005206536,
-0.0013678329,
0.0007223945,
0.0076459623,
-0.03106048,
0.019687526,
0.037998114,
-0.0046372265,
-0.010624909,
-0.0486164,
0.008777962,
-0.012332838,
0.015490521,
0.011247178,
0.010492511,
0.022878308,
-0.0046405364,
-0.0042201737,
-0.018694542,
-0.020839384,
0.015238965,
-0.034608737,
-0.006338536,
0.007824699,
0.023606494,
-0.00087382423,
0.014312182,
0.010313774,
0.009082477,
-0.0036144548,
-0.0088441605,
0.015821515,
0.023156343,
0.004713355,
-0.006818477,
0.014762334,
0.016430544,
0.01333244,
0.01220044,
0.005600419,
0.01889314,
-0.015914192,
0.011564932,
0.029551147,
0.004845753,
-0.008043155,
-0.019250613,
-0.017052813,
0.007652582,
0.0067026294,
0.014378381,
0.00891036,
0.002164701,
0.020773185,
-0.0026992564,
0.0057427464,
-0.008427108,
-0.0365947,
-0.010624909,
0.019118216,
-0.015980393,
-0.009658406,
0.035535518,
-0.034635216,
-0.014060627,
-0.023950728,
0.01775452,
-0.012432136,
-0.0022557243,
0.012862428,
-0.01106844,
-0.0038428407,
-0.014550498,
-0.0128028495,
0.02548654,
-0.007599623,
-0.0043492615,
-0.012253399,
-0.007401027,
-0.006977354,
-0.014576977,
0.016986614,
0.046312686,
-0.025407102,
-0.014113585,
0.009943061,
0.0074142665,
0.02605585,
-0.0009731225,
0.0034059286,
0.010624909,
0.011531832,
-0.01721169,
-0.030345533,
0.0042466535,
-0.033019964,
0.02825365,
-0.005163507,
-0.006302126,
-0.011816487,
-0.013100744,
-0.025420342,
0.026347125,
-0.0022706192,
0.029657066,
0.0018452917,
-0.011267037,
0.006950875,
0.019012297,
0.022163361,
-0.006550372,
-0.016483502,
-0.004200314,
-0.03495297,
-0.013014685,
-0.03275517,
-0.021355735,
-0.024824552,
0.007831319,
-0.0026297476,
0.00020831937,
-0.013087504,
0.023434378,
-0.0072289095,
-0.007930617,
0.011386195,
0.0150933275,
0.013994427,
-0.019383011,
0.04162581,
-0.018535666,
-0.004329402,
-0.008307951,
-0.0141930245,
0.027935896,
0.000053062482,
-0.019780204,
0.01783396,
0.005603729,
-0.031881344,
-0.0128028495,
0.024559757,
-0.0386601,
0.013689913,
-0.0006748141,
-0.025817534,
-0.024851032,
-0.0330994,
-0.012279878,
-0.005233016,
0.0141533045,
-0.025234984,
-0.032967005,
-0.0073480676,
0.005107238,
0.02110418,
0.015689118,
-0.02556598,
-0.008698523,
0.010836745,
-0.0156229185,
-0.013219901,
-0.024652436,
-0.010082078,
-0.031351756,
-0.0027621451,
-0.016999854,
-0.036806535,
-0.0034754374,
-0.0050542788,
0.0343969,
0.012121001,
0.043982487,
-0.019197654,
-0.00084155233,
0.017608883,
0.0034555777,
0.0060571907,
-0.01946245,
0.03503241,
-0.015874473,
0.025751336,
0.02602937,
0.015861234,
-0.0025271394,
-0.02997482,
0.007857799,
0.013795831,
-0.016020112,
-0.012140861,
-0.012074662,
-0.015278685,
-0.024202283,
0.032914046,
-0.018535666,
0.010836745,
-0.028624363,
-0.021196857,
0.032331496,
-0.0022540693,
0.011319996,
-0.014179785,
-0.003551566,
-0.021766167,
0.012432136,
-0.0028945429,
-0.0053587933,
-0.00554746,
-0.0096981255,
0.020667268,
0.014285702,
-0.00092181837,
0.005775846,
0.005272735,
-0.00010953834,
-0.01989936,
-0.0035879754,
0.006983974,
-0.014325421,
-0.012670452,
0.006434524,
-0.02105122,
-0.024149325,
-0.0063484656,
-0.0015987012,
-0.041122697,
-0.008930219,
0.007937237,
0.00553091,
0.003051765,
-0.027141511,
-0.034105625,
0.015953911,
-0.008089494,
0.040169436,
-0.008956699,
0.001083178,
0.027353346,
-0.01443134,
-0.021474892,
-0.01383555,
0.004769624,
-0.018138474,
0.029259872,
0.010704347,
-0.015689118,
-0.016602661,
-0.0146034565,
0.0026429873,
-0.0131735625,
-0.038421787,
0.027273908,
0.010035739,
0.025830774,
-0.012955107,
-0.0052396357,
-0.016523222,
0.012332838,
0.0057890858,
0.00305673,
-0.020270074,
0.0096981255,
-0.0053819628,
0.012948487,
0.013597235,
0.011194218,
0.016192228,
-0.0024526657,
-0.012504955,
-0.01165761,
-0.015914192,
-0.0007211532,
-0.018588625,
0.033231802,
-0.013524416,
0.01719845,
-0.009890102,
0.021832366,
0.0053521735,
-0.0057427464,
-0.019502169,
0.0354296,
-0.0026264377,
0.006712559,
0.045756616,
0.008718383,
0.0010666283,
-0.015265445,
-0.012286498,
-0.017979596,
-0.026797276,
-0.0038891798,
0.038051073,
0.0266384,
-0.029524667,
-0.005719577,
-0.016377585,
0.002055473,
-0.020349514,
-0.012584393,
0.010426312,
-0.033443637,
-0.012392417,
-0.009890102,
0.0052263956,
0.010902943,
-0.0062392377,
0.0029475018,
-0.00276711,
0.018932858,
-0.027326867,
0.025817534,
-0.0077717397,
0.001083178,
-0.001414172,
-0.0034655074,
-0.010989002,
-0.0062557873,
0.037336126,
-0.013286101,
-0.026889956,
-0.01493445,
-0.0029756364,
-0.0009847073,
0.011545072,
-0.0022656543,
0.008777962,
-0.0064212843,
0.004551168,
-0.0079438565,
0.017397046,
0.01109492,
-0.011267037,
0.0013148738,
0.011180978,
-0.0060902904,
-0.009473049,
0.029100996,
0.0024609407,
0.005974442,
0.003104724,
-0.024943711,
-0.037389085,
-0.023023944,
-0.027829979,
-0.008658804,
0.004233414,
-0.018403267,
-0.017357327,
0.001055871,
0.009228114,
0.000215353,
-0.001107175,
-0.00442539,
-0.011333236,
-0.008175553,
-0.02213688,
0.0034588876,
0.010187997,
-0.014550498,
-0.009062617,
-0.006878056,
-0.0017923327,
0.039957598,
-0.010035739,
-0.009585587,
-0.028306609,
0.006143249,
-0.03495297,
-0.036488783,
-0.021766167,
-0.0007252907,
0.028015334,
0.015464041,
0.01605983,
-0.0064808633,
-0.016364345,
-0.006441144,
-0.014643176,
-0.020905582,
0.0024460459,
-0.008427108,
0.0131735625,
-0.010499131,
-0.022653231,
-0.020375993,
0.03161655,
-0.01935653,
-0.015371363,
0.036197506,
-0.02381833,
0.010234335,
-0.010234335,
0.0120283235,
0.021594051,
-0.0042565833,
0.024109606,
-0.023341699,
0.008420488,
0.029657066,
-0.001136137,
-0.007103132,
0.016404064,
-0.0011195873,
0.017105771,
-0.024665676,
-0.0029326072,
-0.032437414,
0.007493705,
-0.021368975,
0.009347271,
0.046100847,
-0.009208254,
0.015861234,
0.0049251914,
-0.015146287,
-0.019237373,
0.0014869907,
0.0033033204,
0.0040646065,
0.022308998,
0.0030914843,
-0.030928083,
0.0024245314,
0.003770022,
-0.024122845,
-0.0005200744,
0.0064576934,
0.005428302,
-0.021607291,
0.0011204148,
0.037627403,
-0.0028945429,
0.0043426417,
0.0119886035,
0.003495297,
-0.0026760867,
-0.008069634,
-0.0067059393,
-0.0016814497,
-0.012842569,
0.0019694145,
0.0038362208,
-0.0027340108,
-0.00007468053,
-0.038977858,
0.0046835653,
0.019303571,
0.17709504,
-0.014325421,
0.000013291479,
0.010048979,
-0.030954562,
-0.009069237,
-0.00015153321,
-0.010936043,
0.007473845,
0.007857799,
0.01782072,
0.006139939,
-0.032278538,
-0.0100688385,
0.015914192,
-0.013981188,
-0.020217115,
-0.0048523727,
-0.02716799,
-0.00887064,
0.015490521,
-0.004336022,
0.009645166,
-0.006490793,
0.04329402,
-0.009022897,
-0.02162053,
0.012577773,
0.020124437,
0.00092264585,
-0.022467876,
0.012504955,
-0.00031796115,
0.010035739,
0.02939227,
0.012716791,
-0.007877658,
-0.000654127,
0.00887064,
0.004005028,
0.0049582906,
0.0050145597,
-0.013405259,
0.001770818,
-0.01051899,
0.0025138997,
0.0014745784,
0.007500325,
-0.034555778,
0.026810518,
-0.056825057,
0.008433728,
0.005302524,
0.013954708,
0.009473049,
-0.0134582175,
0.011869446,
0.016271668,
-0.008539646,
0.031987265,
-0.012465235,
0.0025602388,
-0.018456228,
0.0068317167,
-0.028015334,
0.037945155,
-0.00034630252,
-0.010750686,
0.027353346,
-0.014960931,
-0.010062219,
-0.017463244,
-0.009645166,
0.00942671,
-0.0111214,
-0.0066430504,
0.021978004,
0.034714654,
0.007877658,
0.013067644,
0.0064643133,
0.0012859118,
-0.03985168,
0.016470263,
-0.024136085,
-0.029312832,
-0.000089058085,
-0.0008680319,
-0.0068581966,
-0.009658406,
-0.00079810934,
-0.021567572,
-0.004819273,
-0.017383806,
0.0051237876,
-0.012922007,
0.006977354,
-0.0052197757,
-0.008056395,
-0.018111993,
-0.010055599,
0.0661988,
0.0044419398,
0.024361162,
-0.015556719,
-0.004713355,
-0.009843763,
0.01886666,
-0.024480319,
0.0006624018,
-0.0018668063,
-0.026227968,
-0.0075135645,
-0.012683691,
-0.0012991516,
0.0073414478,
-0.0020207185,
-0.027644621,
0.038077552,
-0.028439008,
-0.003215607,
-0.013914989,
-0.0071627107,
0.006378255,
-0.016404064,
0.010221096,
-0.033019964,
0.026876716,
-0.022083921,
-0.040142957,
-0.016933655,
0.004915261,
-0.006596711,
0.010479271,
0.024798073,
0.010810265,
-0.0076790615,
-0.017291129,
-0.0004600817,
0.0041804546,
0.003154373,
0.0007947994,
0.014669656,
-0.013219901,
0.013491317,
0.007698921,
0.024546517,
0.0019296953,
0.002667812,
0.0011452393,
-0.0051171677,
-0.01711901,
-0.0025718235,
0.028650843,
0.010426312,
-0.0014927831,
-0.014338662,
-0.011459013,
0.007692301,
0.026942914,
-0.0012064732,
0.021819126,
0.032569814,
-0.014272463,
-0.0100688385,
-0.009532629,
-0.16618548,
0.004759694,
0.015159527,
-0.009287693,
0.043982487,
0.0016500052,
0.0005192469,
-0.008168933,
0.016761538,
-0.0066165705,
0.015464041,
-0.020111198,
-0.047451306,
-0.02490399,
-0.00013136325,
0.016509982,
-0.0017542684,
0.024572996,
0.026836997,
0.009386991,
0.039216172,
-0.013822311,
0.013120604,
-0.018178193,
0.020945303,
0.016430544,
0.006778758,
0.004776244,
-0.0055441502,
-0.016774777,
-0.01550376,
0.03717725,
0.021726448,
0.0017128941,
0.030928083,
0.008307951,
0.015384602,
-0.016430544,
-0.020058239,
0.01713225,
0.015927432,
0.014802054,
-0.025314424,
-0.010366733,
-0.015808275,
0.026002891,
0.028597884,
-0.0064014248,
0.015715597,
-0.018231152,
-0.0014092071,
-0.027247429,
-0.0026314026,
0.03595919,
0.010101938,
0.013120604,
-0.0064444537,
0.018231152,
-0.0039057296,
0.0033380748,
-0.016337866,
0.011392815,
0.027882937,
0.0068648164,
0.010141657,
-0.011929025,
-0.011174358,
0.00023417828,
-0.027115032,
0.020985022,
-0.043161623,
0.002775385,
0.023580015,
-0.012379177,
0.018800462,
-0.012332838,
-0.005375343,
0.017052813,
-0.01556996,
0.025698377,
-0.015967153,
0.018694542,
-0.026810518,
-0.024043407,
0.00006495758,
0.011339855,
0.01106844,
0.016509982,
-0.020203875,
-0.0146034565,
0.013226521,
-0.030054258,
0.0005883419,
-0.0244406,
0.023368178,
0.008235131,
0.01889314,
0.0035780454,
-0.008221892,
-0.027565183,
0.040354792,
-0.020190636,
-0.02220308,
0.0034158584,
0.028147733,
0.009717985,
-0.00017459935,
-0.0019230753,
0.056401383,
-0.02339466,
0.0046802554,
0.0074539855,
0.009473049,
0.032278538,
-0.015159527,
0.009797423,
0.010240955,
-0.01721169,
-0.0048987116,
-0.021355735,
0.048192732,
0.020799665,
0.001997549,
-0.0064610033,
-0.008096114,
-0.045279983,
-0.123288654,
-0.03447634,
-0.0047332146,
0.014020908,
-0.032278538,
0.020693747,
0.0040281974,
0.012809469,
-0.0028018644,
0.033152364,
-0.028465487,
0.0056335186,
-0.007374547,
-0.0075069447,
0.008791202,
0.0044022207,
0.0034489578,
-0.005156887,
-0.023937488,
0.023487337,
-0.015305164,
-0.03280813,
0.0024261863,
0.009241354,
0.015119808,
0.0017443385,
-0.012716791,
0.025036389,
-0.0014588562,
0.029100996,
0.018032555,
-0.0055176704,
0.022004483,
-0.008943459,
-0.03280813,
-0.02828013,
0.03214614,
-0.01440486,
0.029683545,
0.0054680216,
0.0057460563,
-0.0012246779,
0.0037402327,
-0.004610747,
0.025949933,
-0.0011559967,
-0.016178988,
0.001412517,
-0.0030103908,
-0.019555127,
-0.034608737,
-0.0013802451,
-0.03423802,
-0.010876464,
0.031510632,
-0.0049649104,
0.020733466,
0.038395308,
-0.01169733,
-0.0023649524,
-0.0014770608,
-0.009506148,
0.0033347649,
-0.0048589925,
0.010929423,
-0.010035739,
-0.0043095425,
-0.036806535,
0.020402472,
-0.029206913,
0.007659202,
0.010783786,
0.005391893,
-0.0070965122,
-0.0050178696,
0.0005060071,
-0.017105771,
-0.015636157,
0.00250397,
-0.0051304074,
-0.023460858,
-0.0188799,
0.016218707,
-0.02222956,
-0.017277889,
0.007268629,
0.019184414,
0.0019429349,
0.01500065,
-0.012935247,
-0.016801257,
0.050258134,
0.0076327226,
-0.0129683465,
-0.00497815,
-0.0007914895,
0.009208254,
-0.014788813,
0.011551692,
-0.000999602,
-0.017079292,
-0.023646213,
-0.056983933,
0.019502169,
-0.006590091,
-0.0058023254,
0.006265717,
-0.0150933275,
0.002115052,
0.00045884048,
0.029365791,
-0.021448413,
-0.024652436,
0.0048490628,
-0.025870495,
-0.0095789675,
-0.02828013,
-0.011677469,
0.029312832,
-0.018562146,
0.0067721377,
-0.0037435426,
0.023090145,
0.012994826,
-0.016205467,
0.009770944,
-0.016245186,
-0.0062326174,
-0.021567572,
0.010664628,
0.006047261,
-0.005689787,
0.013689913,
-0.033019964,
0.0006388185,
-0.0054547815,
-0.0156229185,
-0.009526008,
-0.025658658,
0.01828411,
0.01664238,
0.024758354,
-0.013127224,
-0.023778612,
0.020561349,
0.014007667,
0.03810403,
-0.002388122,
-0.020773185,
0.010254195,
-0.001997549,
-0.019634565,
0.023341699,
0.017794238,
-0.018972578,
-0.030742725,
-0.012551294,
-0.0072355294,
0.00084693095,
-0.013994427,
0.019369772,
0.00016580733,
0.0009838798,
0.0013454907,
-0.0011766838,
0.00039346915,
-0.0006152352,
0.022295758,
-0.01329934,
-0.0054746415,
0.020548109,
0.0020124437,
-0.0222428,
-0.018429747,
-0.013219901,
-0.012663832,
0.022467876,
0.005501121,
-0.014894731,
0.008407248,
0.00053124543,
-0.005041039,
0.016470263,
-0.021474892,
-0.017026333,
0.020349514,
0.0047431444,
0.003273531,
0.010452791,
0.034026187,
-0.008407248,
-0.0050575887,
-0.005593799,
0.018045794,
-0.0077915997,
0.020402472,
0.007844559,
0.019078497,
0.005712957,
0.0075665237,
-0.0007029486,
0.043399937,
0.015397842,
0.0024774903,
-0.010201236,
-0.009512768,
-0.014378381,
0.02281211,
-0.036356386,
-0.027882937,
-0.01553024,
-0.0003692652,
-0.0053587933,
-0.0029226772,
0.011478873,
0.0064676236,
-0.011392815,
0.0024609407,
-0.0040910863,
-0.0110552,
0.008718383,
0.019303571,
0.014245983,
0.011326616,
0.014471059,
0.01383555,
0.0061796587,
-0.014285702,
0.03225206,
-0.025208505,
0.019250613,
-0.020203875,
0.012260019,
-0.017542684,
-0.036409345,
-0.021779407,
-0.00058130827,
-0.0071627107,
0.022083921,
0.053117923,
-0.018138474,
0.09919229,
0.0013744527,
-0.026413323,
-0.010240955,
0.014709375,
0.019184414,
-0.0011369645,
0.011902546,
-0.0049318112,
-0.034185063,
0.023738893,
-0.023037184,
0.045915492,
-0.038580664,
-0.0023368178,
-0.0032487065,
-0.0060737403,
0.0128028495,
-0.009042757,
-0.014140065,
0.025301185,
-0.005881764,
0.0028482038,
0.010863224,
-0.031298798,
0.012922007,
0.032013744,
-0.019290332,
0.0011824762,
-0.03333772,
-0.014775573,
0.030133696,
-0.0039917883,
-0.0017062742,
-0.0034290983,
0.00943333,
-0.008996418,
-0.007864418,
0.024559757,
0.009003038,
-0.009830522,
0.014259223,
-0.015795035,
-0.014047387,
0.011902546,
-0.006143249,
-0.0377598,
0.025129067,
-0.035164807
] |
The immunological synapse (IS) is a junction between the T cell and antigen-presenting cell and is composed of supramolecular activation clusters (SMACs). No studies have been published on naive T cell IS dynamics. Here, we find that IS formation during antigen recognition comprises cycles of stable IS formation and autonomous naive T cell migration. The migration phase is driven by PKCtheta, which is localized to the F-actin-dependent peripheral (p)SMAC. PKCtheta(-/-) T cells formed hyperstable IS in vitro and in vivo and, like WT cells, displayed fast oscillations in the distal SM | [
-0.023521766,
0.0012598572,
0.010557537,
-0.0005709247,
-0.03614028,
0.0049131108,
-0.020210901,
-0.002080925,
0.0014726035,
-0.02295001,
0.028986687,
-0.00642228,
0.0054316795,
0.0018183163,
-0.0022388226,
-0.00068727037,
0.026247578,
0.0026958948,
-0.020064639,
0.012771429,
-0.042469487,
0.002449907,
-0.0011177493,
-0.029039875,
0.010358087,
0.009500453,
0.0016113872,
-0.036645554,
-0.026141206,
-0.0059037106,
-0.010105451,
0.0006756358,
-0.011807421,
0.011787476,
-0.008941994,
-0.0047103367,
0.018016955,
-0.012831263,
0.009088257,
0.009420673,
-0.00042196075,
0.009068312,
-0.0043413546,
0.009932594,
0.022524517,
0.014094444,
-0.0029136275,
-0.0048067374,
-0.007479363,
0.022165509,
0.014333784,
-0.0055912393,
-0.024638684,
0.001751833,
-0.014679497,
-0.020264087,
0.01660751,
0.010604075,
0.014134334,
-0.032098103,
-0.0042914925,
0.0040056147,
-0.023003196,
-0.0006149699,
0.019359916,
0.017112782,
-0.0037396816,
0.014347081,
0.0098794075,
0.0029086412,
0.025768898,
0.041751467,
-0.017352123,
0.0015557075,
0.032310847,
-0.009719848,
0.00008211718,
-0.0060200565,
-0.024093522,
0.018269591,
0.018508932,
-0.045208596,
-0.0093408935,
0.03967719,
0.004793441,
0.018282888,
-0.0034139138,
0.009892704,
-0.007858317,
-0.01173429,
0.025449779,
0.021194853,
-0.0026626533,
0.016939927,
-0.0062926374,
-0.0036665502,
-0.021819796,
0.009447266,
-0.0023601546,
-0.01121572,
-0.001994497,
0.014958726,
0.0056311293,
-0.03167261,
-0.037469946,
-0.007186837,
-0.009899353,
-0.00007681929,
0.020343868,
0.0015108314,
-0.014347081,
0.02064969,
-0.03603391,
-0.041485533,
0.016381467,
0.002757392,
0.00580731,
-0.0004915604,
-0.00075707777,
-0.02469187,
0.018841347,
0.011920443,
0.0102118235,
-0.0077984827,
0.023521766,
0.015849601,
-0.01692663,
-0.010550888,
-0.026606588,
-0.013070603,
0.009899353,
0.019851891,
0.0029751244,
0.010098802,
-0.006359121,
0.0007358862,
-0.021540565,
-0.008423425,
0.015995864,
-0.03707105,
0.010683855,
0.031778984,
0.0012457295,
0.000076247954,
0.015849601,
0.014214114,
0.018149922,
0.023800995,
-0.008636171,
0.017524978,
-0.0026161151,
-0.027843175,
-0.010178582,
-0.0020227523,
0.013323239,
0.03959741,
-0.0061696437,
0.019838596,
0.00094655494,
-0.012891098,
-0.016102238,
-0.006728103,
0.017259046,
0.0037263848,
0.025117364,
0.026752852,
-0.0074860114,
-0.0063690934,
-0.0062926374,
-0.012013519,
-0.0040089386,
0.02647362,
-0.009154741,
0.023880776,
-0.008975236,
0.004444404,
0.0071602436,
0.014174224,
-0.03770929,
-0.028853722,
-0.008649468,
0.018469041,
0.013535986,
-0.0053253067,
-0.013230163,
-0.013323239,
0.012678351,
-0.0009797966,
-0.025808789,
0.006049974,
-0.01050435,
0.015490592,
-0.0069142557,
-0.009753089,
-0.63100564,
-0.028534602,
0.033135243,
-0.02747087,
0.006714806,
0.041964214,
0.0071203536,
-0.012771429,
-0.013436261,
0.015676746,
-0.021194853,
0.016182018,
-0.0048366548,
-0.0032693127,
-0.027005488,
-0.02731131,
0.0016820257,
-0.011920443,
0.020237494,
-0.014413564,
0.0059037106,
-0.012452309,
0.014985319,
0.025994942,
-0.0020426973,
-0.0031446568,
0.028561195,
-0.012193024,
-0.013775325,
0.015583669,
-0.026234282,
0.013562579,
-0.008496556,
-0.0076721646,
0.048692316,
0.0037031157,
-0.010484405,
0.030874811,
0.013921588,
0.050580442,
-0.0128246145,
-0.005710909,
0.0034039414,
0.010710448,
-0.009580233,
0.028242076,
-0.006279341,
-0.006056622,
0.015357626,
-0.029385587,
0.017072894,
-0.0054715695,
-0.040927075,
0.016394764,
0.014666201,
-0.010657261,
0.016541027,
0.0053818175,
0.013422964,
0.028321855,
0.0035900944,
0.020676283,
-0.0114683565,
-0.0031729122,
-0.010397977,
-0.0011194113,
-0.00210087,
-0.0007915659,
0.019718926,
0.008430073,
0.021779906,
0.020795954,
-0.012585275,
-0.00012766858,
0.0070339255,
0.027337903,
-0.0229899,
-0.002493121,
0.012332639,
0.009267762,
-0.00039744505,
-0.0017601434,
-0.021966059,
-0.009679958,
0.011401874,
-0.009925946,
-0.009453915,
0.018163217,
-0.000120293094,
0.008556391,
0.022684077,
0.0003571396,
-0.0021922844,
-0.048160452,
-0.025915163,
0.017365418,
0.010278307,
0.009699903,
0.002120815,
-0.012199672,
0.0011243976,
0.0017850747,
0.0014011341,
-0.004760199,
0.03531589,
0.010564185,
-0.0467776,
0.0028139027,
0.044916067,
-0.04736265,
0.010005726,
-0.009507102,
-0.009653364,
-0.012917691,
-0.0030964564,
-0.019133873,
0.038081594,
0.022391552,
0.005910359,
-0.017897286,
0.019240247,
-0.0014177548,
0.013263404,
-0.011096051,
0.0055014873,
0.014001368,
0.005677668,
-0.019452993,
-0.0057607717,
-0.010889953,
0.004118636,
0.0006814531,
0.011002975,
-0.007000684,
0.015902787,
0.0061031603,
0.016421357,
0.006920904,
-0.00041863657,
-0.033454362,
-0.051590987,
-0.010005726,
-0.0049164346,
-0.03103437,
-0.030981185,
-0.024944507,
-0.0096467165,
0.00020838337,
0.010756986,
-0.015570372,
0.012026816,
-0.0013437923,
-0.0062893135,
-0.0014335446,
0.022617593,
-0.018881237,
-0.033454362,
-0.020795954,
-0.010191879,
-0.012412419,
-0.018402558,
0.032417223,
-0.01165451,
0.014373674,
-0.025502967,
0.010025671,
-0.004344679,
-0.0015798077,
0.0025562802,
-0.046405293,
-0.009081609,
-0.015424109,
-0.00580731,
0.023707919,
0.005172395,
-0.0107237445,
0.0012980851,
-0.0085962815,
-0.0066649434,
-0.00013099273,
0.0029535175,
-0.013934884,
-0.0020460214,
-0.0070804637,
0.023840886,
-0.025981646,
0.03297568,
-0.004590667,
0.0046637985,
0.03183217,
0.011189127,
0.014254004,
0.008496556,
0.010836766,
-0.013409667,
-0.019479586,
0.016541027,
0.022085728,
-0.0015050141,
0.029491961,
0.003583446,
-0.000063262945,
0.02679274,
-0.010803524,
0.010145341,
-0.015729932,
-0.008941994,
-0.015610262,
0.026819333,
0.012020168,
0.021567158,
-0.0015266212,
0.008436722,
0.00079447456,
0.027896363,
-0.0012798022,
-0.012751483,
0.016727181,
-0.003064877,
-0.001690336,
-0.015982568,
-0.003523611,
0.03140668,
-0.02394726,
-0.011627916,
0.021434193,
0.040581364,
0.021673532,
0.0070272773,
-0.0182297,
-0.020729471,
0.008702654,
0.01034479,
0.023814293,
0.0071735405,
0.010218472,
-0.0076256264,
-0.0030798356,
0.042150367,
0.005129181,
0.011322094,
0.018149922,
-0.00063491485,
-0.002961828,
0.012199672,
-0.021394303,
0.020756064,
0.0031596154,
-0.00481671,
0.017272342,
-0.0038560273,
0.002778999,
-0.012665055,
0.032842714,
0.00045873428,
-0.011036216,
0.0003533999,
0.0046704467,
0.031486455,
0.02683263,
-0.007146947,
-0.0049131108,
0.0026709638,
0.0036831708,
-0.009886056,
0.0027141778,
-0.008124251,
-0.005102588,
-0.0013737098,
-0.0063125826,
-0.024519015,
0.010045616,
0.012472253,
-0.015078397,
0.008569689,
0.0029900833,
0.027603837,
0.014599717,
0.008097657,
0.0010745352,
-0.024971101,
-0.04978264,
0.006714806,
0.0135692265,
-0.010132044,
-0.011800773,
-0.028135702,
0.0051956642,
-0.007047222,
-0.008915401,
-0.0005788196,
0.012252859,
-0.00408207,
-0.011435116,
-0.010098802,
-0.02374781,
0.032603376,
0.0074461214,
0.014214114,
0.00013369361,
0.0019496207,
-0.0065153562,
-0.0067081577,
0.0017401985,
0.014905539,
-0.015384219,
0.011701048,
-0.027763397,
0.0037729233,
-0.0060599465,
0.009580233,
-0.0053518997,
0.0030465939,
-0.022285178,
0.0077918344,
-0.018841347,
-0.013462854,
-0.00087425445,
0.03887939,
-0.0060466495,
-0.029491961,
-0.025742305,
0.002720826,
-0.0020343869,
0.014732683,
0.010604075,
-0.015171473,
0.013196921,
0.0013753718,
-0.0072200787,
-0.030555692,
-0.010451163,
0.006528653,
-0.017631352,
-0.028135702,
-0.0017983713,
0.020875733,
-0.017259046,
0.013748731,
0.023003196,
0.0012989161,
-0.009972484,
0.010524295,
-0.009221224,
0.006674916,
-0.015304439,
0.0233888,
0.027497463,
0.029518554,
-0.011867256,
0.020184308,
0.013988071,
0.026167799,
-0.042283334,
0.021952761,
0.03159283,
0.020915624,
-0.02168683,
-0.0064887633,
-0.034863804,
0.0034903695,
0.027018784,
-0.0126717035,
0.0036565776,
0.016660698,
0.020583207,
0.024612091,
-0.0106971515,
-0.0061663194,
-0.0015947664,
0.02088903,
0.0074993083,
0.0039690486,
0.0011243976,
0.0289335,
-0.025556153,
-0.005149126,
-0.03741676,
-0.01764465,
0.008589633,
-0.0024000446,
-0.015251253,
-0.0012249534,
-0.034145787,
-0.014878946,
-0.0025163903,
-0.0025030936,
-0.012139837,
-0.025981646,
-0.04159191,
0.00309147,
-0.013748731,
-0.02374781,
-0.028614381,
0.013988071,
-0.034704246,
-0.032177884,
-0.016780367,
0.016314983,
0.004763523,
0.011342038,
0.007266617,
-0.011076106,
0.045767054,
-0.028534602,
-0.013589172,
-0.0136955455,
-0.022112321,
-0.00864282,
0.025263626,
0.016261797,
0.0024283,
-0.0016313322,
-0.005066022,
0.013223514,
-0.00061289227,
-0.0103913285,
-0.010271659,
-0.0074527697,
0.015823008,
0.02053002,
0.01050435,
-0.020516723,
-0.011189127,
-0.00987276,
-0.06951486,
-0.0014676172,
-0.0082638655,
-0.0037928682,
-0.014759277,
0.0008090178,
0.0102118235,
-0.016873443,
-0.015596965,
-0.003500342,
-0.025915163,
-0.013934884,
0.0063857143,
0.039331477,
0.03667215,
0.0009972485,
0.017192563,
-0.016035754,
-0.015769823,
-0.02374781,
-0.020835843,
0.01918706,
0.004683743,
-0.025755603,
0.0019462965,
-0.008689358,
0.0034671004,
-0.006934201,
0.00092661,
-0.01276478,
0.024027038,
0.0070538707,
-0.013502744,
0.008137547,
-0.008356942,
0.01058413,
0.0029053171,
0.0060632704,
-0.017139377,
0.0058638207,
0.010850063,
-0.0004034701,
-0.02537,
-0.0028122405,
-0.022617593,
-0.0269523,
0.01910728,
0.009148092,
0.002080925,
0.0055646463,
-0.0032360712,
-0.009773035,
0.009121499,
-0.0024648658,
-0.048984844,
-0.019559367,
-0.0064322525,
0.037922032,
0.0424163,
0.033002276,
0.006555246,
0.040129278,
0.022524517,
0.00033823343,
-0.0060665947,
0.003272637,
0.031060964,
-0.010949788,
0.027258124,
0.03151305,
-0.0062294784,
0.00560786,
-0.010936491,
0.013762028,
0.017046299,
0.00041655896,
-0.031114152,
0.010038967,
-0.028773941,
-0.00096483785,
0.0056510745,
-0.0046239085,
-0.0063358517,
-0.025276924,
0.009088257,
0.0052255816,
0.0002783985,
0.0058405516,
0.0035136386,
0.05031451,
-0.012651758,
0.028188888,
-0.019080687,
-0.00010341258,
-0.028109109,
-0.0015149866,
0.00088422693,
0.018203108,
0.027284717,
-0.005079319,
-0.005494839,
0.020795954,
0.01870838,
0.0017817505,
-0.0012706607,
-0.016155424,
-0.00043588068,
-0.011541489,
-0.010870008,
-0.0051823677,
-0.03167261,
-0.037150826,
-0.015344329,
-0.0014933795,
0.014001368,
-0.0075524948,
0.010471108,
-0.029172841,
-0.026247578,
0.043267284,
-0.005597888,
0.010677206,
-0.02310957,
0.01165451,
0.022976603,
0.0042383056,
-0.03278953,
-0.006611757,
0.0028305235,
0.0032277608,
0.028587788,
0.024758354,
0.0031330222,
-0.01926684,
-0.0053651966,
-0.0072400235,
-0.0063225552,
-0.03435853,
0.011827366,
0.015889492,
0.010444515,
-0.025835382,
-0.0028571167,
-0.004730282,
0.015477296,
-0.0035934185,
0.0007458587,
-0.016673993,
0.005498163,
-0.018854644,
0.017033003,
-0.0061862646,
0.015198066,
0.0008933684,
-0.010630668,
-0.0037463298,
-0.027284717,
0.006525329,
0.004826682,
0.006628378,
0.023867479,
0.001008883,
0.009799628,
0.015530482,
0.012392473,
-0.012020168,
0.006635026,
-0.010012374,
0.033667106,
0.006881014,
-0.014147631,
0.0067580203,
-0.016408062,
0.01066391,
-0.03425216,
0.008875511,
0.00039495193,
-0.02291012,
-0.0027773369,
0.013549282,
0.017790912,
-0.0010595764,
-0.009440619,
-0.015477296,
-0.0063125826,
-0.016700586,
0.0049097864,
-0.0065220045,
-0.0440119,
-0.009187982,
-0.0035701494,
0.013296646,
0.016208611,
0.008749193,
0.010404625,
-0.010677206,
0.03560842,
-0.013037361,
0.005514784,
0.037922032,
0.010477757,
0.009001829,
0.007658868,
-0.010843415,
-0.023215944,
0.026978893,
0.00107038,
-0.024718463,
0.0012930988,
0.0019230273,
0.009074961,
0.005664371,
-0.02148738,
0.0130307125,
0.023827588,
0.016434655,
0.017365418,
-0.0035867703,
0.020011451,
-0.032629967,
-0.005169071,
0.016009161,
-0.027337903,
0.0027939577,
0.023003196,
-0.0051590987,
0.012778076,
-0.014985319,
0.006295962,
-0.026008239,
0.007984635,
-0.016381467,
-0.00058380584,
0.005641102,
0.0032593403,
-0.020383758,
0.015118286,
0.00018449096,
-0.017259046,
-0.01700641,
0.008662765,
0.0045042387,
0.019373212,
-0.005189016,
0.0053120097,
0.0036166876,
-0.024213191,
-0.030901404,
0.000813173,
-0.028640974,
0.034597874,
0.012080003,
-0.000545578,
-0.0082638655,
-0.006927552,
-0.06366434,
-0.00011873489,
0.004507563,
-0.019160466,
0.010045616,
0.00848326,
-0.022551112,
-0.0060300287,
0.008689358,
0.0135426335,
-0.011794125,
-0.016275095,
0.024651982,
0.0009490481,
0.0065220045,
0.02778999,
-0.021234743,
-0.013841808,
0.029305806,
-0.0046438533,
0.010650613,
0.013329887,
-0.012638462,
0.0076522194,
0.014639607,
-0.0010712111,
-0.01870838,
0.0040421803,
0.044304423,
-0.0039058896,
0.004593991,
0.016474543,
-0.021407599,
-0.002451569,
0.018841347,
-0.007964691,
0.01858871,
0.011913794,
0.027032081,
-0.024279675,
0.01181407,
-0.01121572,
0.024638684,
0.010949788,
-0.007904856,
0.017139377,
-0.015490592,
-0.0036166876,
-0.015357626,
-0.0014235721,
-0.029119654,
-0.0064123073,
0.010198527,
-0.0036399567,
0.001751833,
-0.011115996,
0.01494543,
-0.04454376,
-0.012851208,
0.00864282,
0.013176976,
-0.03677852,
0.015065099,
0.026433732,
-0.036725335,
-0.00046164292,
-0.0052222577,
-0.019705629,
-0.014227411,
0.011242314,
0.0043579754,
0.00019248972,
0.0061895885,
-0.0020842492,
-0.027231531,
0.010038967,
-0.010517647,
-0.009839518,
-0.017618056,
0.0026958948,
0.19487564,
-0.03140668,
-0.012146486,
0.011182479,
-0.008709303,
-0.007805131,
0.013170328,
-0.0083237,
0.008868863,
-0.0037164125,
0.020024749,
0.004264899,
-0.002818889,
-0.004650502,
0.022710672,
-0.00055721257,
-0.0041419053,
-0.0044809696,
-0.013775325,
-0.0063358517,
0.021740016,
-0.009154741,
0.011036216,
0.0012673365,
0.031778984,
-0.006399011,
-0.017604759,
-0.012179728,
0.011461709,
0.021500677,
-0.038932577,
0.028853722,
0.010092154,
0.002697557,
-0.010112099,
0.0065918122,
-0.016168721,
0.0021557186,
0.018402558,
0.022192102,
-0.0103647355,
0.0028571167,
-0.009234521,
-0.0032576781,
-0.013482799,
-0.01359582,
0.0036632258,
-0.0053053615,
-0.0059269797,
0.004740254,
-0.03005042,
-0.0237877,
-0.012046761,
0.006525329,
0.008981884,
0.0125187915,
-0.00044252898,
0.03887939,
0.010564185,
-0.003024987,
-0.010737041,
0.014373674,
-0.035927538,
0.044916067,
-0.0043081134,
0.027138453,
-0.0038992413,
0.007891559,
0.009201279,
-0.011302149,
-0.0035468803,
0.010604075,
-0.012146486,
-0.022936713,
-0.020064639,
0.0066017844,
0.03175239,
-0.015503889,
0.0034471555,
0.010983029,
-0.00088505796,
0.0051624225,
-0.031060964,
0.002800606,
0.0036765225,
-0.013037361,
0.032922495,
-0.0016421358,
-0.03675193,
-0.004740254,
0.0052255816,
-0.0022820367,
-0.0042848443,
-0.015769823,
0.01189385,
-0.009414026,
0.011541489,
-0.0057940134,
-0.017830802,
-0.0032643266,
0.0025596044,
0.082864694,
0.041751467,
0.017112782,
-0.004653826,
0.0053518997,
0.012744835,
-0.0075259013,
-0.001338806,
-0.016873443,
0.008662765,
-0.016155424,
-0.0060433256,
-0.0035734735,
-0.023162756,
0.012738187,
-0.009234521,
-0.007658868,
0.041990805,
-0.019479586,
0.009786331,
-0.029624926,
0.0021939466,
0.032310847,
0.0010678868,
0.011834014,
-0.010637317,
0.010078858,
-0.0026676396,
-0.034544684,
0.019865189,
0.016235204,
0.005544701,
0.04119301,
-0.005102588,
-0.023402097,
-0.007313155,
-0.013868402,
-0.022883527,
0.01482576,
-0.01858871,
-0.013369777,
0.0014933795,
0.016221907,
-0.00018615303,
0.0036931434,
0.039730377,
0.026872521,
-0.02104859,
-0.014214114,
0.010078858,
-0.012452309,
-0.012578627,
-0.0022753885,
0.029598333,
-0.014613014,
-0.034305345,
-0.020436944,
-0.010471108,
0.0077319993,
-0.0147991665,
0.016501138,
0.014666201,
-0.0049397037,
-0.014373674,
-0.00081815926,
-0.16668674,
-0.0021756636,
0.02064969,
-0.01323681,
0.016049052,
0.000029008503,
0.0151049895,
0.011255611,
-0.014001368,
0.01042457,
0.034066007,
-0.0050161597,
-0.03497018,
-0.0076921093,
0.011461709,
0.020357164,
0.0013637373,
0.027258124,
0.023348909,
0.007658868,
0.011993574,
-0.041166414,
0.019984858,
-0.01470609,
0.0027507436,
0.021394303,
0.0021357737,
-0.0070139808,
-0.0047203093,
-0.011940388,
-0.012020168,
-0.0072998586,
0.0088289725,
-0.006588488,
0.030396132,
0.013383074,
-0.030768437,
0.0023767755,
0.008476611,
0.044304423,
0.05568635,
0.004058801,
0.0045009144,
0.010138692,
-0.020303978,
0.008602929,
-0.012232914,
-0.0112622585,
0.021899575,
0.00412196,
0.0031995054,
0.004444404,
0.00075042946,
0.021567158,
0.014692794,
0.020995403,
0.012099948,
0.007811779,
0.010830118,
0.008543095,
0.0054050866,
-0.006192913,
0.02957174,
-0.017418606,
-0.025742305,
-0.017844098,
0.00007759839,
0.015317736,
-0.006834476,
0.00006212026,
-0.0076522194,
-0.006777965,
-0.0035900944,
-0.023654733,
0.0049795937,
-0.0062328028,
0.0049563246,
-0.0036366326,
0.010005726,
-0.00039225104,
-0.011122644,
0.012379177,
-0.013383074,
-0.0018133301,
-0.0045408043,
-0.003397293,
0.011647861,
0.017737726,
-0.01347615,
0.0057308543,
0.0030798356,
-0.032390628,
0.008609578,
-0.0042981408,
0.035182923,
0.020051342,
-0.03917192,
0.006974091,
0.0025064177,
0.0023219266,
0.011268907,
-0.0051358296,
-0.0067846132,
0.008456667,
0.010491054,
-0.00049987074,
0.0011077768,
-0.005747475,
0.028188888,
-0.004454376,
-0.0065020598,
-0.016408062,
0.027337903,
0.042815197,
-0.009620124,
0.023441987,
0.009746442,
-0.010005726,
0.002780661,
-0.032177884,
0.075897254,
0.0025247005,
-0.0045640734,
0.0019429723,
-0.014041258,
-0.020995403,
-0.14424202,
-0.031805575,
0.022723967,
0.011149237,
-0.010816821,
0.0032078158,
-0.010756986,
0.017471792,
-0.03151305,
0.022364957,
-0.014134334,
-0.016368171,
-0.004943028,
-0.024253082,
0.0014086134,
0.02200595,
0.004633881,
-0.015636856,
-0.015783118,
0.029465366,
-0.0072865617,
-0.009527046,
-0.005704261,
0.015477296,
0.018774863,
-0.006239451,
-0.010358087,
0.018828051,
0.00955364,
0.022351662,
0.007206782,
-0.014347081,
0.024346158,
-0.0038327582,
-0.018189812,
0.021301227,
-0.028800534,
-0.015769823,
0.025077473,
-0.0013487785,
-0.019878486,
0.002265416,
0.0026709638,
-0.0083237,
-0.019572662,
-0.01462631,
-0.011900498,
-0.0119270915,
0.0194264,
-0.027869768,
-0.008689358,
-0.03677852,
-0.035129737,
-0.022976603,
0.0072001335,
0.016421357,
0.008104306,
0.0034671004,
-0.0101852305,
0.018734973,
0.021061886,
-0.009241168,
-0.016182018,
-0.0030332974,
0.030848218,
-0.009580233,
-0.022099026,
-0.035023365,
0.026912412,
-0.0050992635,
0.003048256,
-0.012498847,
-0.024465827,
-0.012937636,
-0.02505088,
-0.0233888,
-0.012246211,
-0.018695084,
-0.012212969,
-0.021314522,
-0.01926684,
-0.028853722,
0.0062926374,
-0.0017036328,
0.04403849,
-0.0014684483,
0.02485143,
-0.010796877,
0.037017863,
-0.002385086,
0.012598571,
0.01676707,
0.019080687,
-0.005046077,
-0.013216866,
-0.005478218,
-0.0032211123,
-0.011248962,
0.0368583,
0.02116826,
-0.014759277,
-0.00071137055,
-0.05696283,
0.022803748,
-0.0064156316,
0.007519253,
0.00079779874,
-0.015384219,
-0.008450018,
-0.02755065,
0.008749193,
0.016221907,
-0.008104306,
0.011960333,
-0.017777616,
0.014972023,
-0.024186598,
-0.010324845,
0.011787476,
-0.011142589,
0.025742305,
0.022325069,
-0.030103605,
-0.02410682,
-0.0044776453,
0.0073397486,
-0.015902787,
-0.00037542247,
-0.011049513,
0.024319565,
-0.00943397,
0.0074860114,
0.013921588,
-0.03643281,
-0.024452532,
0.018881237,
-0.035103146,
-0.014227411,
0.011820718,
0.04209718,
0.010836766,
0.040368617,
-0.026965598,
-0.022723967,
-0.0024798245,
-0.0050959396,
-0.015397516,
-0.027444277,
-0.029119654,
0.0074993083,
0.00408207,
-0.024425939,
0.03497018,
0.012060057,
0.021381006,
-0.032177884,
-0.00824392,
0.033826668,
0.028321855,
0.014307191,
-0.014878946,
-0.037656102,
0.014134334,
0.016408062,
0.0035601768,
0.036246657,
0.013336536,
-0.035502043,
-0.050128356,
0.011727641,
-0.009919298,
0.0011027906,
-0.023721216,
0.018442448,
-0.008543095,
-0.0052156094,
0.0031330222,
0.005883766,
-0.021859685,
0.0038394064,
-0.0013412992,
-0.0060466495,
0.013416315,
-0.0077585927,
-0.004883193,
0.0033324717,
0.032177884,
-0.0019263516,
-0.006628378,
0.047708366,
-0.008130899,
0.0031164014,
-0.0056676953,
0.007871614,
0.006525329,
0.007725351,
0.017751021,
0.024120115,
0.0075923847,
0.016514434,
0.00020786397,
0.032443814,
-0.0045441287,
0.007107057,
0.019559367,
-0.023441987,
-0.0074195284,
0.013775325,
-0.02941218,
-0.037310388,
-0.021859685,
0.0013845132,
-0.0097132,
0.002306968,
0.016421357,
0.0024765003,
-0.026526809,
0.0032244367,
0.016673993,
0.0043745963,
-0.015690042,
0.020104527,
0.0137221385,
-0.00097481033,
0.00107038,
-0.015158176,
0.005189016,
0.0053818175,
0.02501099,
-0.03103437,
0.02049013,
0.0042316574,
0.0051624225,
-0.014014664,
-0.018881237,
-0.011514896,
-0.020370461,
-0.014107741,
0.0026792742,
0.022032542,
-0.00951375,
0.088502474,
0.018216405,
-0.0062693683,
-0.0026859224,
-0.024199896,
-0.0004367117,
0.011740938,
0.0031263737,
-0.013602468,
-0.043985303,
0.029518554,
-0.012837911,
0.042629045,
-0.021899575,
-0.021660237,
0.0015847939,
-0.019692332,
0.014932133,
-0.021660237,
-0.022591,
0.007166892,
-0.016900036,
0.011255611,
0.017990362,
-0.030289758,
0.0007184344,
0.009733144,
-0.016049052,
0.023122868,
-0.048905063,
0.008882159,
-0.0075724395,
-0.05536723,
-0.01494543,
0.0006440563,
-0.011900498,
-0.011754234,
-0.017883988,
0.010205176,
0.018841347,
-0.0103647355,
0.033321396,
-0.031140745,
-0.04371937,
0.0027424332,
0.019173764,
-0.021381006,
-0.0031778982,
-0.025542857
] |
Microtubule nucleation is an essential step in the formation of the microtubule cytoskeleton. We recently showed that androgen and Src promote microtubule nucleation and γ-tubulin accumulation at the centrosome. Here, we explore the mechanisms by which androgen and Src regulate these processes and ask whether integrins play a role. We perturb integrin function by a tyrosine-to-alanine substitution in membrane-proximal NPIY motif in the integrin β1 tail and show that this mutant substantially decreases microtubule nucleation and γ-tubulin accumulation at the centros | [
0.0037135256,
-0.012758949,
0.0033962305,
-0.028203992,
-0.024685208,
0.019474184,
-0.009011847,
0.00838733,
-0.001979316,
-0.021475324,
0.038008235,
0.004455559,
0.018601203,
0.008749953,
0.012913398,
0.0018181502,
0.030057397,
0.008232879,
-0.018386316,
0.03435515,
-0.035160977,
0.02046804,
-0.0008469591,
-0.025047831,
-0.008709661,
0.016358314,
0.024859803,
-0.043461006,
-0.005815394,
-0.030245423,
-0.007856826,
0.0035624327,
0.010569781,
-0.01138904,
-0.008723091,
0.007507634,
0.03016484,
-0.0140885655,
-0.0034516314,
-0.01792968,
-0.00036723947,
0.006456699,
0.0069569843,
-0.0070174215,
-0.0045193536,
-0.008770098,
0.0037907506,
0.007829965,
-0.026135698,
0.016841812,
0.01621058,
0.016868673,
-0.018681787,
-0.021408172,
-0.013202154,
-0.012335888,
-0.0037672473,
0.01905784,
0.017271588,
-0.018923536,
-0.011610643,
0.008333608,
-0.015109281,
0.019742794,
-0.01962192,
0.018547483,
0.020159138,
-0.016385175,
-0.005211023,
-0.011724802,
0.02674007,
0.03559075,
-0.011201014,
-0.013040989,
0.0057784608,
-0.032582324,
-0.031991385,
-0.032958377,
-0.010072854,
0.019044409,
0.005677732,
0.0033156478,
0.005580361,
0.019474184,
-0.0056441557,
0.010710801,
0.0023771937,
-0.0019088058,
0.006423123,
0.0011424295,
0.024779221,
0.021112703,
0.024268864,
0.02790852,
-0.014424327,
0.009213304,
-0.01308128,
0.01966221,
-0.007776243,
-0.009287171,
-0.008454482,
0.0002610548,
0.009408046,
-0.02073665,
-0.012040419,
0.002469528,
0.017701361,
-0.0347312,
0.008044853,
0.0028808361,
-0.019957682,
0.026229711,
-0.000060437123,
-0.037739627,
0.010777954,
0.0018450111,
0.012611213,
0.013725942,
-0.015552486,
-0.016949255,
0.023006398,
0.032394297,
0.031749636,
0.010220589,
0.03298524,
0.014612353,
0.0066212225,
0.013349889,
-0.020897815,
-0.026095407,
0.028203992,
0.007474058,
-0.010314602,
0.01873551,
-0.019809946,
-0.003841115,
-0.0051304405,
-0.017553627,
-0.039727338,
-0.0414733,
-0.004801394,
0.044857778,
-0.023382451,
0.0046435855,
-0.0044689896,
0.030594615,
0.029842509,
-0.00016798583,
0.015592778,
-0.0027666772,
0.01794311,
-0.006721951,
0.014733228,
-0.016895534,
-0.0050498573,
0.030487172,
-0.0086828,
0.011845676,
0.005247957,
-0.003978777,
0.020360596,
-0.0130141275,
0.018144568,
-0.011852392,
0.039378144,
0.026270004,
0.016049415,
0.007279316,
0.0025685779,
-0.004244029,
0.016062845,
0.0014320241,
-0.038626038,
0.021045549,
-0.011751663,
0.0108988285,
0.00090655684,
0.020548623,
-0.022294583,
-0.0041634464,
-0.021448463,
-0.018681787,
0.025262717,
0.016371746,
-0.01621058,
-0.025182135,
0.016170288,
0.0041869497,
-0.0030789357,
-0.013524486,
-0.017795375,
0.000026533051,
-0.0012414793,
-0.021461895,
-0.6244632,
-0.017607348,
0.040210832,
-0.011791955,
-0.0110062715,
0.03099753,
0.02445689,
0.015740514,
-0.004885334,
0.019084701,
-0.012570922,
0.03532214,
0.032636046,
-0.021273868,
-0.02531644,
-0.0341134,
-0.018332595,
-0.009602788,
0.017567057,
-0.020978397,
-0.013504339,
-0.0047073807,
0.028418878,
0.0022613558,
0.012597783,
-0.014491479,
0.034301426,
-0.0039687045,
-0.018977256,
0.022214001,
-0.013034273,
0.010878682,
-0.008420906,
0.0013833386,
0.041285273,
-0.0049457713,
-0.02986937,
0.029923093,
-0.000019214494,
0.027827937,
-0.018950395,
-0.0043279696,
0.020991828,
-0.020642636,
-0.0108652515,
0.021730503,
-0.014330314,
-0.011684511,
0.0035993664,
-0.00017816361,
0.002927843,
-0.0043279696,
-0.018252011,
0.0072188787,
0.002629015,
0.00052882486,
0.010522774,
-0.011892683,
-0.006792461,
0.028821792,
0.0021169782,
0.013135002,
-0.013752803,
-0.025840228,
-0.014934685,
0.0147466585,
-0.042494014,
0.019044409,
0.0001354589,
0.029493317,
0.018547483,
0.021179855,
-0.012752233,
0.009878112,
0.022039404,
0.034838643,
-0.009716947,
0.0085082045,
-0.008783529,
0.0025433956,
0.006762243,
0.0011843997,
-0.013403611,
-0.0057515996,
0.016922396,
0.0071584415,
-0.02443003,
0.032233134,
0.0029815647,
-0.013484194,
0.0023671207,
0.005996706,
-0.003559075,
-0.038061958,
-0.017258156,
0.029788787,
0.013558062,
0.0147466585,
0.010099715,
-0.037847072,
-0.008407475,
-0.0071584415,
-0.0012121001,
-0.007903833,
0.031212417,
-0.006742097,
-0.03902895,
0.011536775,
0.026766932,
-0.037202407,
0.013900539,
-0.0059026927,
-0.011308458,
-0.013061134,
-0.018950395,
-0.016882103,
0.0035523598,
0.014384036,
0.007561356,
-0.0027381375,
0.004992778,
-0.0045831488,
0.022549763,
-0.010791385,
0.021206716,
0.011818815,
-0.014733228,
-0.005029712,
-0.014652645,
0.004959202,
-0.01792968,
0.0007336395,
0.0409898,
-0.03212569,
0.034167122,
0.017835667,
0.012792525,
-0.007547925,
-0.0027196705,
-0.051895343,
-0.033925373,
-0.009253595,
0.013269306,
0.0021790941,
-0.00038990338,
-0.0134640485,
-0.03384479,
0.003542287,
0.013403611,
0.0030789357,
-0.006362686,
-0.004401837,
-0.014558632,
0.024658347,
0.008588787,
0.009381184,
-0.024282293,
-0.041607603,
0.0041634464,
-0.013390181,
0.0015847957,
0.016318023,
-0.02563877,
0.01790282,
-0.008696231,
-0.026122268,
0.008253025,
-0.014034843,
-0.009361039,
-0.02077694,
0.0060202093,
-0.01337675,
-0.035725057,
0.009629648,
-0.021972252,
0.014397466,
0.003602724,
0.0073598986,
-0.003068863,
-0.0030184987,
-0.0053990497,
-0.031749636,
-0.008138866,
-0.0009468483,
0.022025974,
0.015847957,
0.029949952,
0.0028808361,
0.012577637,
0.024779221,
-0.035053533,
-0.005247957,
0.0069502695,
0.0018332595,
-0.006137726,
-0.034865506,
0.023651062,
0.018722078,
-0.020763509,
0.028257713,
0.0020733292,
-0.032474883,
-0.0026004752,
-0.019205576,
0.010697371,
0.0019642066,
-0.015552486,
-0.010589927,
0.0057717455,
0.0010677226,
0.02363763,
-0.0075546405,
-0.002407412,
-0.0012935223,
0.023006398,
-0.0016670574,
-0.01536446,
-0.008917834,
-0.023006398,
-0.009414761,
-0.021461895,
-0.018440038,
0.012792525,
-0.019165283,
-0.016734367,
0.004677162,
0.010200444,
0.003612797,
-0.0011256414,
0.009159582,
-0.012718657,
0.0114897685,
0.009078999,
0.015297308,
0.0046872348,
0.019084701,
-0.0080582835,
-0.0071450113,
0.0380351,
-0.014276592,
0.019460754,
0.006100792,
-0.018910104,
0.0067823883,
0.020575482,
-0.0025266076,
0.038867787,
0.016035983,
-0.00025119178,
0.00966994,
-0.000047662437,
0.006725309,
0.004297751,
-0.003911625,
0.000035333684,
-0.018440038,
0.009622933,
0.013598353,
0.034032818,
0.023449603,
-0.007843396,
-0.008796959,
0.0049356986,
-0.035214696,
0.0017761799,
0.003515426,
0.039136395,
0.0065540704,
-0.014357175,
0.0006341701,
-0.022214001,
0.01849376,
0.020817231,
-0.0057616723,
0.010294457,
0.0019625276,
0.026323725,
0.0015134463,
0.0020112132,
-0.0037873932,
-0.013255876,
-0.034838643,
0.0392707,
0.009448337,
-0.019541336,
-0.019487616,
-0.011832246,
0.012470193,
-0.01351777,
0.013383466,
-0.0022076338,
-0.011268166,
0.0049121953,
0.0040459298,
-0.027196705,
-0.029359011,
0.010361609,
-0.024577763,
0.0024460247,
-0.0093744695,
0.01735217,
-0.00093929365,
-0.009985556,
-0.004798036,
0.014558632,
-0.0087163765,
-0.010804814,
-0.017875958,
-0.036477163,
-0.02645803,
0.017043268,
-0.008179157,
-0.003191416,
-0.017325308,
-0.005741527,
-0.002012892,
0.014880963,
-0.004025784,
0.02986937,
-0.0042574597,
-0.016707508,
-0.030406589,
0.0026071903,
-0.0015100887,
0.030916946,
0.02017257,
-0.0049121953,
0.019286158,
-0.017956542,
0.020293443,
-0.008320177,
-0.034328286,
0.032394297,
-0.033603042,
-0.006997276,
-0.0075009186,
0.006496991,
0.008199303,
0.023409313,
0.032313716,
-0.012725372,
-0.0073397527,
0.004902122,
-0.0041634464,
0.023409313,
-0.0016981153,
0.013719227,
0.048833195,
0.0121478615,
0.001828223,
0.004183592,
0.017956542,
0.00043439184,
-0.017244726,
-0.008051568,
-0.0022512828,
-0.0032048463,
0.007024137,
-0.021273868,
-0.034838643,
0.014907824,
0.04066747,
0.007198733,
0.0063257525,
-0.00085493346,
-0.0009972126,
0.0056206523,
0.0073733293,
-0.003824327,
-0.027210137,
0.037094966,
-0.0070107062,
-0.018950395,
-0.013779664,
0.0021236935,
-0.008971555,
-0.016009122,
-0.031427305,
0.0071315807,
-0.0032484955,
0.013833386,
-0.013685651,
-0.013323029,
-0.029332152,
-0.014075135,
-0.02562534,
-0.0010240735,
-0.030514032,
-0.0033290782,
-0.009199874,
-0.013913969,
-0.005177447,
-0.020709788,
0.0053990497,
0.01281267,
-0.025128413,
-0.05173418,
-0.008622363,
0.014558632,
0.03357618,
0.0091327205,
0.0033979095,
-0.014531771,
0.03333443,
0.0021824518,
-0.001749319,
-0.0023184353,
-0.022348305,
-0.001749319,
0.0099989865,
0.009945264,
0.0013715869,
-0.010677225,
-0.012591068,
0.011704656,
-0.02506126,
0.031830218,
-0.019111563,
-0.0060202093,
-0.0075210645,
0.012134432,
0.004086221,
0.008085144,
-0.006063858,
-0.018923536,
-0.03156161,
-0.01565993,
-0.027142985,
-0.024094267,
-0.00252325,
-0.0054460564,
-0.008790244,
-0.008145581,
-0.022966107,
0.0044488437,
-0.021757364,
0.004301109,
-0.007568071,
0.009468483,
0.034059677,
0.004603294,
0.027827937,
-0.02451061,
-0.014276592,
0.0036799493,
-0.012866392,
0.025276149,
0.0023503327,
-0.014034843,
0.027048972,
-0.0106235035,
0.0017980045,
-0.02730415,
0.008642509,
-0.0045227115,
0.0250344,
0.014786949,
-0.027774217,
0.0028002535,
-0.011449478,
-0.028096547,
-0.0070980047,
-0.014451188,
-0.021314159,
-0.003995565,
-0.0027549255,
-0.0011096927,
-0.0013480836,
0.0052345265,
-0.029385872,
-0.010301172,
0.020642636,
0.004814824,
0.003498638,
-0.006208236,
0.01929959,
-0.023436174,
-0.029573899,
-0.02050833,
-0.037497878,
-0.0007143332,
-0.013141717,
0.011523345,
0.019232435,
0.049074944,
0.0014387394,
0.02075008,
0.009441622,
0.011771808,
0.0072524548,
0.015149573,
0.026592335,
-0.030782642,
0.017271588,
0.023785366,
0.019124992,
0.01929959,
-0.013712512,
0.015834527,
0.016076274,
-0.015753943,
-0.018816091,
-0.0002467849,
-0.029144125,
-0.029090403,
0.02304669,
-0.011308458,
-0.017526766,
-0.032286856,
-0.019648781,
0.016170288,
0.012906684,
0.030299146,
-0.0041298703,
0.0007697339,
-0.0022898954,
0.020132277,
-0.014048274,
0.010764523,
-0.00611758,
-0.025383592,
0.0042675324,
0.0014420969,
0.006557428,
0.0038646183,
0.014101996,
0.014786949,
0.007863541,
-0.0030806146,
0.0341134,
-0.004851758,
-0.014692936,
-0.00639962,
-0.024994109,
-0.024886664,
-0.02134102,
-0.02079037,
-0.02790852,
-0.008400761,
0.009575927,
-0.008521634,
0.010354894,
0.00031162892,
-0.0018030409,
0.033495598,
-0.0038444726,
0.016532911,
-0.019769656,
0.011959835,
0.030916946,
0.0068193222,
-0.011201014,
-0.0043615457,
-0.018426608,
0.014330314,
0.027935382,
0.036853217,
-0.00462344,
-0.020333735,
0.007876972,
-0.014934685,
-0.00441191,
-0.028768072,
0.009038707,
0.013417042,
0.009844536,
-0.01010643,
-0.009978841,
-0.020548623,
0.020629205,
0.008749953,
-0.003911625,
-0.010636934,
0.0012087425,
-0.013806526,
0.026001394,
0.0073531833,
0.029761925,
-0.003958632,
-0.015471904,
0.018869814,
-0.0025702566,
0.00062535633,
-0.003401267,
-0.014491479,
0.020884383,
-0.005070003,
0.0070174215,
0.02249604,
0.008313462,
-0.0025652202,
-0.015028698,
-0.000026244506,
0.05235198,
-0.011637504,
-0.015471904,
0.024631485,
0.0040123537,
0.0058758315,
-0.013712512,
0.003110833,
-0.0019188786,
-0.03787393,
-0.0072994614,
0.019474184,
-0.0018668356,
-0.011838961,
-0.014249731,
-0.008655939,
0.0027465315,
0.0006967057,
-0.000038350292,
0.015619639,
-0.057804752,
-0.027989104,
0.0011382325,
0.031695914,
0.0054124803,
-0.010583212,
-0.015310738,
-0.024604624,
0.026901236,
-0.029681344,
0.027774217,
0.0085082045,
-0.008293317,
-0.02217371,
-0.003807539,
0.002504783,
-0.029359011,
0.026780361,
-0.0162643,
-0.023745075,
0.020535192,
-0.009038707,
0.022308014,
0.010556351,
-0.0048920494,
0.0029547038,
-0.0022999684,
0.025329871,
0.011765094,
0.015686791,
-0.011415902,
-0.013994552,
-0.0074673425,
0.0017476402,
-0.027129553,
-0.009925119,
0.008830535,
-0.0054863477,
0.018332595,
-0.023140702,
0.012000127,
-0.016062845,
0.0010148401,
-0.017164143,
0.010408616,
0.020669496,
-0.029493317,
-0.014813811,
0.0028422237,
-0.014827241,
-0.016949255,
-0.004529427,
0.00025643807,
0.008998416,
-0.0080582835,
-0.018654926,
0.01281267,
0.020145709,
-0.024577763,
-0.037148684,
0.0021707,
-0.016398607,
0.040264554,
-0.0078098197,
-0.0049491287,
-0.005617295,
-0.0025635413,
-0.036181692,
-0.030943807,
0.018856382,
-0.006557428,
-0.008709661,
-0.00576503,
-0.009488628,
0.004210453,
-0.0043917643,
0.008004561,
0.015874818,
-0.016895534,
0.019232435,
-0.013229015,
0.015283877,
0.01281267,
-0.02279151,
0.0002474145,
0.03333443,
-0.009663224,
-0.016398607,
0.022630345,
0.000032763008,
-0.0066077923,
-0.0039351285,
-0.00051455497,
0.008830535,
0.014961546,
0.029063541,
-0.031266138,
-0.007997846,
0.0108988285,
0.0014420969,
-0.018762369,
0.008501489,
-0.01993082,
0.009199874,
0.017164143,
0.006617865,
-0.024873234,
0.015633069,
-0.0069636996,
0.038088817,
0.032555465,
0.021596199,
0.014827241,
0.0038209693,
0.0038579032,
-0.009199874,
0.009515489,
-0.017862529,
-0.014840672,
-0.011543491,
0.0026222996,
-0.01451834,
-0.0003842374,
-0.0027012036,
-0.015176433,
-0.011691226,
0.016089706,
-0.0050465,
-0.0112815965,
0.018050555,
0.0074136206,
0.00045915425,
0.016667215,
-0.012497054,
-0.016626924,
-0.03701438,
0.0011466265,
-0.009636364,
-0.021273868,
-0.004334685,
-0.0015898321,
0.008118721,
0.02079037,
-0.022093127,
-0.02246918,
0.0012633038,
0.02671321,
0.20091987,
-0.021112703,
0.0030638264,
-0.00028162022,
-0.011207729,
-0.018936966,
0.012503769,
0.008575357,
-0.0085417805,
-0.0019574913,
0.03212569,
0.041419577,
-0.0011054957,
-0.007312892,
0.026565474,
-0.024416598,
-0.019084701,
0.0020011403,
-0.018748939,
0.011523345,
0.020306874,
-0.020427749,
0.011442762,
0.012483624,
0.047624454,
-0.005378904,
-0.033603042,
-0.0041970224,
-0.008830535,
0.015713653,
-0.03529528,
0.006167944,
-0.000046245943,
-0.03209883,
0.013739373,
0.006688375,
-0.015821096,
0.0061746594,
0.009058854,
0.015431613,
0.009643079,
-0.025679063,
-0.0018601203,
0.005170732,
-0.0076083625,
-0.003770605,
-0.009011847,
-0.0073531833,
-0.0067689577,
0.02414799,
-0.0603834,
-0.0016989547,
0.014961546,
0.024242003,
-0.012047133,
0.0046973075,
0.007192018,
0.016532911,
0.015028698,
0.02447032,
-0.0074942033,
0.016841812,
-0.034784924,
0.019192144,
-0.013531201,
0.03188394,
-0.030003674,
0.006231739,
0.014652645,
-0.013699082,
-0.006527209,
-0.000025142788,
-0.0046435855,
0.017607348,
-0.003841115,
-0.026565474,
0.034032818,
0.014531771,
0.025155274,
0.024443459,
-0.002927843,
0.012255305,
-0.022925816,
-0.0042742477,
0.0006299731,
-0.0121142855,
0.016049415,
-0.00068033737,
0.003998923,
-0.02359734,
0.0103817545,
-0.00866937,
0.0046100095,
-0.014048274,
0.020588914,
-0.009703516,
0.013511055,
-0.010845106,
-0.01733874,
-0.0034063035,
-0.031266138,
0.068119355,
0.027425025,
-0.007057713,
-0.015888248,
-0.0030033893,
0.0027398162,
-0.004193665,
-0.0250344,
-0.01764764,
0.004428698,
-0.03212569,
0.013497625,
-0.004442129,
-0.023933101,
0.0014706367,
0.027277289,
-0.023261577,
0.03389851,
0.00018036705,
-0.013618499,
-0.015297308,
0.0008431818,
0.019850237,
-0.008749953,
-0.00021803532,
-0.020159138,
0.006601077,
-0.010804814,
-0.021958822,
0.0048383274,
0.010019132,
-0.0038310422,
0.0018869813,
-0.021824516,
-0.01480038,
0.019219005,
-0.024953816,
-0.0018399747,
-0.000028775836,
-0.013135002,
0.00490548,
0.0136722205,
0.024255432,
-0.0062350966,
-0.018977256,
0.010556351,
0.021596199,
-0.004613367,
-0.022052836,
-0.0048416853,
-0.0029379157,
0.0121814385,
-0.0003718562,
0.013282737,
-0.0134640485,
-0.009260311,
-0.034543175,
-0.0057616723,
0.025759645,
-0.012752233,
0.000778128,
0.030460311,
0.0016452328,
-0.0070442827,
-0.0018231865,
-0.16890162,
0.00824631,
0.016197149,
-0.03835743,
0.029708205,
0.017043268,
-0.011254735,
0.012866392,
0.00045579663,
-0.026216282,
0.032877795,
0.0049961354,
-0.04244029,
-0.020991828,
0.008138866,
-0.0012456763,
-0.0054359837,
0.016519481,
0.021421602,
0.009085714,
0.022724358,
-0.03588622,
0.032555465,
-0.00012486141,
-0.0054829903,
0.030460311,
-0.012154577,
-0.021649921,
-0.003797466,
-0.010717517,
0.0046435855,
0.009481913,
0.026780361,
-0.012248591,
0.043219257,
0.030326005,
0.00043565093,
-0.00047384383,
-0.0025568262,
0.013692366,
0.034382008,
0.030890085,
0.03948559,
0.0046838773,
-0.02217371,
0.02614913,
-0.00611758,
0.012718657,
0.02648489,
-0.017217865,
0.02788166,
0.0018131137,
0.0093879,
0.010509345,
0.027559329,
0.027398163,
-0.0028892304,
0.034274563,
0.0073531833,
0.004657016,
0.0057717455,
-0.013900539,
0.043622173,
-0.016747799,
0.005775103,
-0.041097246,
-0.014854102,
-0.001969243,
-0.049639024,
0.012866392,
-0.005106937,
0.006651441,
0.0021555908,
-0.024000254,
0.004042572,
0.017231295,
-0.008837251,
0.028687488,
0.004421983,
-0.0008070874,
-0.011503199,
0.017271588,
-0.011711372,
-0.017271588,
-0.0065708584,
0.01818486,
-0.00037206605,
0.010697371,
-0.0016536269,
0.0134640485,
0.0050330693,
-0.023516757,
-0.011885968,
0.0015948686,
0.029224707,
-0.004190307,
-0.012188153,
-0.00725917,
0.007648654,
-0.019809946,
0.014880963,
-0.0049491287,
-0.023570478,
0.017768515,
0.026941527,
0.018681787,
0.0017291732,
-0.003559075,
0.020105416,
0.004025784,
0.00075084734,
0.0012255305,
-0.0027784288,
0.009589357,
-0.004798036,
0.03158847,
0.016600063,
0.00397542,
0.005956414,
-0.019165283,
0.059362687,
0.0044454862,
-0.011012987,
-0.0012507127,
0.003710168,
-0.0466306,
-0.13022186,
-0.020629205,
0.003313969,
0.026283434,
0.0013875356,
0.010213874,
-0.0069099776,
0.037927654,
-0.006134368,
0.027169844,
-0.04606652,
-0.012946975,
-0.0069569843,
0.0065171365,
-0.029923093,
-0.008763383,
0.020038264,
-0.0140885655,
-0.036342856,
0.01764764,
-0.0090991445,
-0.0045663603,
0.0011424295,
0.019030979,
-0.0016150143,
0.008306747,
-0.037524737,
0.018346025,
0.0016141748,
0.012591068,
-0.013605068,
-0.007312892,
0.031266138,
-0.013913969,
-0.026686348,
-0.022428889,
-0.010099715,
-0.01153006,
0.024228571,
0.011912828,
0.005402407,
0.023825657,
0.021408172,
0.010683941,
-0.0045764334,
-0.016761228,
-0.018923536,
0.009891543,
0.0009779063,
0.00067865854,
-0.01850719,
0.0064802025,
-0.018977256,
-0.033065822,
0.013484194,
0.0019675642,
0.0084410515,
0.019138422,
-0.005157301,
0.0037336713,
-0.0067286664,
0.014706367,
0.0016175325,
0.025397023,
0.021730503,
-0.020763509,
-0.010959265,
-0.037041243,
0.017486475,
-0.018440038,
-0.0009913368,
-0.012221729,
-0.029573899,
-0.0042171683,
-0.03553703,
-0.0015856351,
-0.021878239,
-0.024604624,
0.021797657,
-0.013255876,
0.0016955971,
-0.020535192,
0.010777954,
-0.016841812,
0.020360596,
-0.006530567,
0.009596072,
-0.0013103104,
0.010704086,
-0.008347038,
-0.0111070005,
0.03725613,
-0.0018299018,
-0.006137726,
0.00866937,
0.015606209,
-0.0010593284,
-0.005882547,
0.020011403,
0.015458473,
-0.01901755,
-0.032958377,
-0.06371416,
0.01764764,
-0.0009997308,
0.0053285398,
-0.0076083625,
-0.010892113,
0.020078555,
-0.010334748,
-0.006453342,
0.018359454,
-0.015619639,
0.0066749444,
0.005738169,
-0.0028757998,
-0.0284726,
-0.023852518,
0.04010339,
-0.025249287,
0.0043783337,
0.02335559,
-0.012188153,
-0.0003968285,
0.0048618307,
0.008259741,
0.009434907,
-0.022684067,
-0.010563066,
0.02021286,
-0.009797529,
0.019084701,
0.034865506,
-0.05004194,
0.0074673425,
-0.004385049,
0.0033022172,
-0.018399747,
-0.018171428,
0.025732784,
0.012705226,
0.027989104,
-0.019178715,
-0.02815027,
0.0019977826,
0.005123725,
-0.011718087,
0.0112815965,
-0.031695914,
-0.009703516,
0.0013539594,
-0.021663351,
0.023288438,
0.0006102471,
-0.0069838455,
-0.023798797,
-0.0035019955,
0.0012045455,
0.00010009899,
-0.0154047515,
-0.013356605,
-0.03585936,
0.0067353817,
0.027935382,
-0.012510485,
0.017204436,
0.02414799,
0.011039848,
-0.043138675,
0.02135445,
0.008326893,
-0.027277289,
-0.023100412,
-0.0013128286,
0.008635794,
-0.0013573171,
-0.027720494,
-0.0032249922,
-0.03271663,
-0.021193285,
-0.009857967,
0.013054418,
0.013793095,
0.027559329,
-0.019715933,
0.006644726,
0.0016099778,
-0.005308394,
0.011885968,
0.031722777,
0.003814254,
-0.006231739,
-0.004599937,
0.013833386,
0.019675642,
0.012275452,
0.011483054,
0.04077491,
-0.0034180551,
0.010146721,
-0.0013657111,
0.012852962,
0.01508242,
-0.0102743115,
0.009763953,
-0.022657206,
0.008555211,
0.029090403,
-0.04316554,
-0.027827937,
-0.014424327,
-0.015163003,
-0.0068428256,
0.027989104,
0.001871872,
-0.0067555276,
-0.009515489,
0.009555781,
0.008071714,
-0.016318023,
-0.00066312955,
0.012168008,
0.015458473,
0.02135445,
-0.016720938,
-0.0017778587,
0.03072892,
-0.0066212225,
0.033495598,
-0.022079697,
0.030379727,
-0.0019289516,
0.023677923,
-0.017593918,
-0.0506866,
0.0009267026,
0.007843396,
-0.015230156,
0.006161229,
0.019138422,
-0.000782325,
0.093798414,
0.008333608,
-0.0108988285,
0.017164143,
-0.00782325,
0.023382451,
0.006567501,
0.0029110548,
-0.035751916,
-0.03158847,
0.009555781,
0.007910548,
0.009844536,
-0.03924384,
-0.011342034,
0.02418828,
-0.021931961,
0.028929237,
-0.0014538486,
-0.0033643332,
0.015673362,
-0.04206424,
0.005442699,
0.02707583,
-0.009025278,
0.014934685,
0.012523916,
0.015780805,
0.013819955,
-0.050256826,
0.0051035793,
-0.00074665033,
-0.02815027,
-0.002681058,
-0.008380614,
-0.0054863477,
-0.019527907,
-0.009253595,
0.029466456,
0.016156858,
-0.0026474819,
0.002558505,
-0.007427051,
-0.028042825,
-0.0033626545,
0.0032820716,
-0.0017677859,
0.0019390244,
-0.017083561
] |
Little is known about longitudinal associations between added sugar consumption (solid and liquid sources) and glucose-insulin homeostasis among youth. Caucasian children (8-10 y) with at least one obese biological parent were recruited in the QUébec Adipose and Lifestyle InvesTigation in Youth (QUALITY) cohort (n = 630) and followed-up 2 y later (n = 564). Added sugars were assessed by 3 24-h dietary recalls at baseline. Two-year changes were examined in multivariate linear regression models, adjusting for baseline level, age, sex, Tanner stage, energy intake, fat mass ( | [
0.0055215554,
-0.014497006,
0.018932957,
-0.02709671,
-0.011310337,
-0.0029010714,
0.009346226,
-0.0071883774,
-0.015659438,
-0.00732199,
0.022901261,
0.003226753,
-0.0055115344,
0.012980499,
-0.0142565025,
-0.0014864441,
0.040164057,
-0.01751666,
-0.010815969,
-0.011811386,
-0.01846531,
0.008083584,
0.0062597673,
-0.0056317863,
-0.0068743867,
0.012345837,
0.0037278016,
-0.017690357,
0.006513632,
-0.00907232,
0.019053208,
-0.015926665,
-0.0141629735,
0.004686475,
-0.00567187,
0.0021645299,
-0.015165071,
0.00978715,
0.021070763,
-0.035407435,
0.016541284,
0.0077896356,
-0.0020676604,
-0.002319855,
-0.00288771,
0.0010079427,
-0.0011808046,
-0.0115976045,
0.0038113096,
0.017596826,
-0.0064668674,
0.030036194,
-0.015365491,
-0.0073153097,
-0.00525767,
-0.0015407244,
0.0015624366,
0.019240266,
-0.0019190161,
-0.024090417,
0.011884873,
0.002483531,
-0.0296888,
0.0006413422,
-0.00959341,
0.002351588,
-0.017823968,
0.021271184,
0.005174162,
0.022259919,
0.015084903,
0.036396172,
0.013100751,
0.021885803,
0.0187459,
-0.0003123203,
-0.0017169266,
-0.013381338,
-0.0010296549,
0.005291073,
0.0152586,
-0.01773044,
-0.030463755,
0.046871427,
-0.002855977,
0.018024389,
0.0066973497,
0.020870345,
-0.005454749,
0.001987493,
-0.0216453,
0.022393532,
0.026522173,
0.020229002,
-0.01165105,
-0.00068017346,
-0.012325795,
0.04425261,
-0.009012194,
0.012392602,
-0.019013124,
0.007435561,
-0.008183794,
-0.011276934,
-0.011089875,
-0.016046917,
-0.017396407,
-0.0008075233,
-0.011784663,
-0.011430589,
-0.016193891,
0.039014984,
0.0017854032,
-0.01164437,
-0.022834456,
0.00381465,
-0.014790955,
-0.007308629,
0.00010219304,
-0.0060393056,
0.020349253,
0.017810607,
0.026455367,
-0.009833914,
0.0029127626,
0.0148444,
-0.012873609,
-0.009139126,
-0.025960999,
-0.026148057,
-0.01659473,
-0.01216546,
0.0033887587,
0.013869025,
-0.017757162,
0.012152099,
-0.020188918,
-0.0017787225,
-0.016073639,
-0.0118047055,
0.0044793743,
0.02176555,
-0.02453134,
0.018411865,
0.0014079466,
0.0385607,
0.019213544,
0.020710008,
-0.015619355,
-0.014002638,
-0.00072401523,
0.0061896206,
0.027136791,
0.030249974,
0.047218822,
0.00030981505,
0.0015908293,
0.0402175,
-0.05422014,
0.01206525,
-0.0069411932,
-0.012492812,
-0.0017119161,
0.013354615,
-0.010762524,
0.017489936,
0.017329602,
-0.026027804,
0.007455603,
-0.007883165,
-0.012813482,
0.023930082,
-0.01825153,
0.0045929453,
0.013180918,
0.017717078,
-0.002835935,
-0.000100731646,
-0.015285322,
-0.012392602,
-0.01720935,
0.023262016,
0.013007222,
0.029715523,
-0.013989277,
-0.015552549,
-0.02103068,
0.022420255,
0.008237239,
-0.019026486,
-0.008818455,
0.029020734,
-0.019039847,
-0.023956804,
-0.6580171,
-0.01298718,
-0.005514875,
-0.013641884,
-0.020041944,
0.03628928,
0.02135135,
0.022727564,
0.0002210877,
0.01794422,
0.006947874,
0.05042553,
0.018064473,
-0.0067474544,
-0.0018371782,
-0.027497547,
0.006744114,
-0.021618577,
0.0029211133,
-0.016541284,
-0.013247725,
0.033162735,
-0.0040250905,
0.0065804385,
0.042836316,
0.019614382,
0.015619355,
-0.01825153,
-0.0024785204,
-0.0005503184,
-0.0034839578,
0.013053986,
0.021164292,
0.014323309,
0.047886886,
-0.026735954,
-0.01330117,
0.018224807,
0.0073553934,
0.025934275,
-0.033777356,
-0.018117918,
0.019908331,
0.017075736,
-0.006506951,
0.004362463,
-0.010228072,
0.031826608,
0.021818995,
-0.024598146,
0.007041403,
-0.010909498,
-0.014149613,
-0.04238203,
0.034391977,
-0.022219835,
0.014203058,
-0.018719176,
0.011777982,
0.01040845,
0.00019185986,
0.015793052,
-0.00907232,
-0.0022847815,
-0.020870345,
0.017676994,
-0.016380949,
0.029314684,
0.015712883,
0.002638856,
0.006577098,
0.032040387,
0.005307775,
0.0063332543,
0.028673341,
0.012245628,
0.038934816,
0.030891316,
-0.01794422,
-0.0047466005,
0.005939096,
0.007268545,
-0.009853955,
0.0061896206,
0.007849761,
-0.012853567,
-0.00097036414,
0.015525826,
-0.032975677,
-0.0204027,
0.024157222,
0.0080969455,
-0.008203836,
-0.028994013,
-0.02103068,
0.0352471,
-0.04216825,
0.0032718473,
0.021698745,
-0.001660141,
-0.007435561,
0.020710008,
-0.0055649797,
0.0013486558,
0.01710246,
0.01247277,
-0.0069345124,
0.009713662,
0.028833676,
-0.03351013,
0.012532895,
0.0034672562,
-0.00773619,
0.011878192,
0.0010304899,
-0.0208169,
-0.002154509,
-0.015966749,
-0.005939096,
-0.01464398,
0.0027056625,
0.022206474,
0.0036008693,
0.00043883506,
-0.0032902192,
0.025707133,
0.0020659904,
-0.0041085985,
0.0037845871,
-0.013448144,
0.0044459715,
0.019013124,
0.028726786,
-0.0027223642,
0.0032935594,
-0.015512465,
0.015485742,
-0.015365491,
-0.009600091,
-0.027898386,
-0.006637224,
-0.0039649648,
0.012145418,
-0.019948415,
0.0007549132,
-0.009767108,
0.012359199,
-0.0072017387,
-0.003764545,
-0.0077562323,
-0.0059491172,
-0.01381558,
-0.015111626,
0.015325407,
-0.016848594,
0.004906936,
-0.022300003,
-0.027297128,
0.001371203,
0.022380171,
0.0024150542,
0.02092379,
-0.009900721,
-0.017757162,
0.007415519,
-0.01627406,
-0.023636132,
-0.0056618494,
-0.008451019,
-0.015686162,
-0.0081169875,
-0.04072523,
-0.012639786,
0.022620674,
0.0023616091,
0.02227328,
-0.014710787,
0.015699523,
-0.0048200875,
-0.00875833,
0.0062597673,
0.011570882,
-0.022861177,
0.00093362055,
0.019747995,
0.021124208,
-0.0007737026,
0.02083026,
0.0015039808,
0.018532118,
-0.01062223,
0.02763116,
-0.025707133,
0.00013945853,
-0.00017286176,
-0.020229002,
-0.0054514087,
-0.0078364005,
-0.0029845794,
0.0031165222,
0.028994013,
-0.0028760189,
0.01576633,
-0.00649359,
0.02732385,
-0.026735954,
0.024411088,
-0.015846496,
0.029341405,
0.007970013,
0.002339897,
0.0034939789,
0.008945388,
0.005792122,
-0.007956652,
0.01102975,
-0.00014165061,
-0.008651439,
-0.018077834,
0.010167946,
0.010067737,
-0.01742313,
0.026949733,
-0.012539577,
-0.0079098875,
0.02506579,
0.009760426,
0.007916568,
-0.007990055,
-0.014510367,
-0.0041119386,
0.003392099,
-0.007008,
0.0111299595,
-0.0086581195,
0.0035808273,
0.0067808577,
-0.022006055,
-0.000638837,
0.0288604,
0.006213003,
0.015485742,
0.026067888,
0.02093715,
0.013989277,
-0.015485742,
0.038026247,
0.025306294,
-0.011864831,
0.0030430353,
0.012132057,
0.028806955,
-0.0220595,
0.0005315291,
-0.00711489,
0.0066472446,
0.014096167,
-0.0017119161,
0.016207252,
0.025266211,
0.009473159,
0.034872983,
-0.037037514,
-0.011684453,
0.00005725524,
-0.0014714127,
-0.011764621,
-0.024464533,
0.015138349,
-0.00896543,
-0.04101918,
-0.004265594,
0.007843081,
-0.02792511,
0.018104557,
0.004576244,
0.016848594,
-0.014002638,
0.008584633,
0.0029094222,
0.0016100361,
-0.011103237,
0.009025555,
0.031292155,
-0.008704884,
0.0021528387,
0.01545902,
-0.013722051,
-0.009727024,
0.00011054385,
0.01700893,
0.008938707,
0.005267691,
-0.01639431,
-0.019547576,
0.00028246615,
0.012746677,
-0.024958901,
-0.0022346769,
0.00041795804,
0.003412141,
0.015953388,
-0.019106653,
-0.005281052,
0.03596861,
0.0030580666,
0.005905693,
0.0022079542,
0.015512465,
-0.013347935,
-0.012466089,
-0.013748773,
-0.0073954775,
0.029448297,
0.024785204,
0.013107431,
-0.003340324,
0.018612286,
0.033750635,
-0.020041944,
-0.018986402,
-0.040377837,
-0.030249974,
-0.004569563,
0.06520312,
0.020215642,
0.000665142,
0.02875351,
0.010795928,
0.011123279,
-0.0057253153,
-0.0065203123,
0.009105723,
0.010522021,
-0.011965041,
0.014189696,
0.014403477,
-0.011256892,
0.0045127776,
-0.010668995,
-0.008324088,
-0.04331732,
-0.012452728,
0.013361296,
0.013521631,
-0.0026121333,
0.024397727,
0.04363799,
0.03824003,
-0.020549674,
0.007802997,
0.035407435,
-0.0032518054,
-0.008818455,
0.0076025776,
0.00958005,
-0.003671016,
0.02391672,
-0.007829719,
-0.011250211,
0.020322531,
-0.007996736,
0.0133212125,
0.0053445185,
0.0216453,
-0.0023682897,
0.0035407434,
-0.0015749627,
-0.0022046138,
-0.009927443,
-0.018117918,
0.05029192,
-0.0007544957,
-0.0074622836,
0.034605756,
-0.017489936,
0.012639786,
-0.022754287,
0.016407672,
-0.014443561,
0.0069411932,
-0.021939248,
-0.013454825,
-0.028406115,
-0.007308629,
-0.0018455291,
0.019079931,
-0.009934124,
-0.012659828,
-0.0061662383,
-0.004412568,
-0.015499104,
-0.019788079,
0.012379241,
0.0024300858,
-0.0049503604,
-0.0111299595,
0.009686939,
0.013935831,
0.026963096,
0.0074622836,
-0.004893575,
-0.003362036,
0.018585563,
-0.027684605,
0.00608273,
-0.015806412,
-0.00089437177,
0.020482866,
-0.004556202,
0.020255724,
-0.01154416,
-0.021925887,
0.0023950124,
-0.02422403,
-0.0066238623,
0.007856442,
-0.017503297,
-0.027310489,
-0.02050959,
0.014563813,
-0.008704884,
-0.003278528,
-0.010582146,
0.004883554,
-0.012225586,
-0.02712343,
-0.0007753727,
-0.00027119255,
0.0023432374,
-0.005080633,
-0.012699912,
0.00041545279,
-0.021885803,
0.013595119,
-0.02259395,
-0.008170432,
0.007869803,
0.01143727,
0.022353448,
-0.013561715,
0.01267987,
0.013635202,
-0.018264892,
0.006420103,
-0.029662076,
0.022540506,
-0.0010463565,
-0.019133376,
0.018077834,
-0.01020135,
-0.023555964,
-0.027791496,
-0.013935831,
0.0046129874,
0.032093834,
0.0073553934,
0.011717857,
-0.03599533,
-0.0002609628,
-0.012713273,
0.0057687396,
-0.0061896206,
-0.007208419,
-0.016421033,
0.000505224,
0.015499104,
-0.020629842,
0.030811148,
-0.03163955,
-0.0064802286,
-0.012880289,
-0.009446437,
0.014804316,
-0.021792274,
-0.007990055,
-0.016674897,
-0.007495687,
-0.0034505548,
-0.008531188,
-0.03123871,
0.020282447,
0.0410459,
0.0061896206,
0.029127626,
0.005925735,
-0.0039182003,
0.00048392944,
0.006817601,
0.00034008673,
-0.012025166,
-0.00030000284,
-0.0016943794,
0.012218906,
-0.01206525,
0.03236106,
-0.0003382078,
0.0060493266,
0.024264114,
0.021899164,
-0.017583465,
-0.029715523,
-0.018652368,
-0.038774483,
-0.0017094108,
0.0140694445,
0.0034472144,
0.011731218,
-0.025626965,
-0.023342185,
0.016474478,
0.014002638,
0.012392602,
0.002032587,
0.022032777,
-0.046256807,
0.04617664,
-0.0060660285,
-0.0049369987,
-0.0018588903,
-0.028299225,
0.0060426462,
-0.0027474165,
0.024050333,
-0.00086430885,
-0.008223877,
-0.0006208827,
-0.0043457616,
-0.013681967,
-0.0105687855,
-0.026134696,
-0.008885262,
0.00090689794,
-0.033323072,
0.010896137,
-0.016848594,
-0.0148444,
0.00096034317,
-0.0011323699,
0.0058722897,
-0.029261239,
0.017984305,
-0.019975137,
-0.018625647,
-0.019360518,
0.0069545545,
0.02875351,
-0.009392991,
0.037064236,
0.030223252,
0.012860248,
-0.009747066,
0.0068677063,
0.014109529,
-0.008170432,
0.0305172,
0.007041403,
0.0036008693,
0.023662856,
0.000006586049,
0.023542603,
-0.01320096,
-0.021845719,
0.0067274123,
0.00608273,
-0.0023682897,
-0.025105875,
-0.0040017082,
-0.01918682,
0.017676994,
-0.003463916,
-0.0072551835,
0.00835749,
0.00073153095,
0.0031515956,
0.05948449,
0.015405574,
0.008464381,
0.0049637216,
-0.009860637,
0.016167168,
-0.033884246,
-0.03762541,
-0.0008743298,
0.013521631,
0.013935831,
0.004152023,
0.011109917,
-0.0009311153,
-0.007288587,
-0.0043324004,
0.018665731,
-0.014831038,
0.030437032,
0.0051173763,
-0.006022604,
0.01370869,
0.005030528,
0.018785981,
0.003981666,
-0.0056585087,
-0.017957581,
-0.027871663,
-0.010689037,
0.019413963,
0.027684605,
-0.0065002707,
0.0085645905,
-0.009560008,
-0.008711565,
-0.01361516,
-0.019026486,
0.0076560224,
-0.026829483,
-0.017302878,
-0.0033052505,
0.0044693537,
0.016421033,
0.0051374184,
-0.0015398894,
-0.022954706,
0.01587322,
-0.032868788,
0.03794608,
0.01794422,
0.019200182,
-0.0054614297,
0.013100751,
-0.011724537,
-0.0041119386,
0.020656563,
0.017463215,
-0.028112167,
-0.017249433,
0.009125765,
0.017316239,
0.012112015,
0.0077562323,
0.0022296663,
0.016461117,
0.009219294,
-0.003514021,
-0.009112404,
0.01814464,
-0.012218906,
-0.0023348865,
0.016033554,
-0.021912526,
0.017783886,
0.004990444,
-0.012071931,
0.00045386652,
-0.022607313,
-0.0079299295,
-0.028700063,
0.033884246,
-0.011944999,
0.025600243,
-0.017049015,
-0.00044593326,
-0.012893651,
0.02041606,
-0.018598923,
-0.011283615,
-0.015632717,
-0.0034405338,
-0.0023966825,
0.0015515805,
0.0028058721,
-0.01102975,
-0.013675286,
-0.0033536854,
-0.025319656,
-0.021271184,
-0.015312045,
0.030784426,
0.0041420017,
-0.036476336,
-0.008043501,
-0.0013695329,
-0.005695252,
0.011998444,
0.0079098875,
0.008036819,
-0.010314921,
-0.0010129532,
-0.0035607854,
0.042301863,
-0.011076515,
0.020322531,
-0.030490477,
-0.02752427,
0.0028492964,
0.0044058873,
0.025733856,
-0.0037912678,
-0.013762135,
0.001526528,
0.017049015,
-0.020028582,
0.003164957,
0.009767108,
0.0076961066,
0.015018097,
-0.026522173,
0.036209114,
0.016220612,
-0.013314531,
0.0053745816,
0.0021277864,
0.008811775,
0.016541284,
-0.030704258,
0.002740736,
-0.052937455,
-0.0049102763,
-0.0237163,
0.00011753765,
-0.0077762743,
-0.014978013,
-0.008952068,
-0.0052610105,
0.005989201,
-0.002607123,
0.007983374,
0.0004793365,
0.0037278016,
-0.008030139,
0.0048501506,
0.002855977,
-0.014884484,
-0.010642272,
-0.002102734,
-0.017823968,
-0.0069545545,
-0.0059624785,
0.00752909,
-0.009433075,
0.012880289,
-0.003268507,
-0.010996346,
-0.0062397253,
0.0074756453,
-0.004402547,
-0.028299225,
-0.013334573,
0.030730981,
-0.008070223,
0.00659714,
0.009600091,
-0.00006069995,
-0.027844941,
0.009820553,
-0.0011883202,
-0.007863123,
-0.010769204,
-0.0069879577,
-0.029234516,
-0.008932026,
-0.003009632,
0.1931509,
-0.013388019,
0.012218906,
0.047779996,
-0.008130348,
-0.012953777,
0.024718398,
0.021110848,
-0.0057787606,
0.011918276,
-0.000551571,
0.009225975,
-0.006887748,
0.0037578645,
0.011911595,
0.00978715,
-0.036556505,
-0.017877415,
0.014790955,
-0.023275377,
-0.017262794,
-0.013367977,
-0.005093994,
-0.024010248,
0.033109292,
0.0012083622,
-0.012359199,
-0.014363393,
0.001123184,
0.029501742,
-0.0050238473,
0.011303657,
0.0033904288,
0.031158542,
-0.01679515,
-0.017436491,
-0.00046639272,
-0.020710008,
0.018478673,
0.027283767,
0.019921692,
-0.010789246,
-0.011390504,
-0.02176555,
-0.0233021,
0.014136251,
0.0070881676,
0.0010638932,
-0.01875926,
-0.0005093994,
-0.01288697,
-0.017650273,
0.012746677,
0.005578341,
-0.005822185,
0.0056518284,
0.0090522785,
0.014871122,
-0.0024384365,
0.016140446,
-0.029982748,
0.014042722,
-0.009246017,
0.022781009,
-0.024571422,
-0.00085011247,
-0.0044259294,
-0.023676217,
-0.018478673,
-0.026829483,
0.0041253003,
-0.017596826,
-0.021939248,
0.007709468,
-0.00628983,
-0.00026785224,
0.017810607,
0.011791344,
0.010141224,
0.0013219332,
-0.0048501506,
-0.0022129647,
-0.027257044,
-0.004068515,
-0.024865372,
-0.029127626,
0.016006833,
-0.007896526,
-0.023769746,
0.0042622536,
0.008958749,
0.014978013,
0.005491493,
0.0005390448,
-0.009773788,
-0.036022056,
-0.017864052,
-0.007415519,
0.013869025,
-0.020910429,
-0.018398505,
0.05804147,
0.026415283,
0.028673341,
-0.0136953285,
-0.020683287,
-0.009165849,
-0.0043992065,
0.000499796,
-0.01886615,
0.009152488,
-0.0424622,
0.0058088233,
-0.0025202744,
-0.020082029,
0.008651439,
-0.0021494986,
-0.025373101,
0.013020583,
-0.012546257,
0.0031816587,
-0.0095199235,
0.027083347,
0.03041031,
-0.011764621,
-0.0012501163,
-0.01720935,
-0.012152099,
-0.0075892163,
-0.043798327,
0.010107821,
-0.037865914,
-0.012806802,
0.006420103,
-0.005063931,
-0.0064167622,
-0.031265434,
0.017236073,
0.006506951,
0.009686939,
-0.020055305,
-0.027016541,
0.012619744,
-0.011497395,
0.02711007,
-0.04184758,
0.0021895824,
0.00043674736,
-0.010815969,
-0.0034472144,
-0.0014789285,
0.022954706,
-0.004606307,
-0.012746677,
0.0071082097,
-0.021284545,
-0.028593173,
-0.03848053,
-0.010094459,
-0.00006049118,
-0.016821872,
0.01877262,
0.010468575,
-0.0018171363,
0.00009253741,
0.0119917635,
-0.1697419,
0.02350252,
0.011791344,
-0.011985082,
-0.014323309,
-0.01763691,
0.030249974,
0.016968846,
-0.008631397,
0.0021778913,
0.030330142,
-0.010769204,
-0.02586747,
0.011691134,
0.004359123,
-0.011290295,
-0.008945388,
0.029475018,
0.020803537,
0.0019223564,
0.019146737,
-0.011657731,
0.02712343,
-0.0029294642,
0.014096167,
0.030356865,
0.006279809,
0.013020583,
-0.028325947,
-0.01320096,
-0.0068743867,
-0.004452652,
0.030971484,
0.011864831,
0.00021816492,
-0.005494833,
-0.04040456,
0.001937388,
0.005762059,
0.012252308,
0.040965732,
0.032948956,
0.0048067262,
0.022233197,
0.0077762743,
0.02463823,
0.019560937,
-0.018545479,
0.0004329895,
-0.0135082705,
0.017329602,
-0.02133799,
0.01226567,
0.010749163,
-0.015111626,
-0.005267691,
0.0031081715,
0.0017503297,
0.023889998,
-0.009533285,
-0.018826066,
-0.01845195,
0.023275377,
-0.007996736,
-0.0027908408,
-0.0418743,
-0.005281052,
-0.0064167622,
-0.022861177,
0.0018939637,
-0.03546088,
-0.002710673,
-0.00017181791,
0.0057787606,
0.013434784,
0.008831817,
0.014309948,
-0.008611355,
0.017169265,
-0.0071683354,
0.008170432,
-0.01627406,
-0.039977,
-0.0026171438,
-0.015953388,
0.029394852,
0.002545327,
0.030704258,
0.015352129,
-0.020963874,
0.0019156758,
-0.02411714,
-0.009947485,
-0.02792511,
-0.006072709,
0.009506562,
-0.004990444,
0.008497784,
0.019520853,
-0.003001281,
0.00097036414,
-0.029635355,
-0.016113723,
0.0031148521,
0.011791344,
-0.033830803,
-0.03340324,
-0.012826844,
0.037705578,
-0.012913693,
-0.020950513,
0.00013423926,
-0.004245552,
0.01630078,
-0.009479839,
0.044466395,
-0.015271962,
-0.012900331,
0.0408054,
-0.023221932,
0.04238203,
0.006216343,
-0.01102975,
0.00639338,
-0.0002457226,
-0.0028008616,
-0.12249636,
-0.02052295,
0.010375046,
0.01453709,
0.01794422,
0.012252308,
0.00046305242,
-0.006720732,
-0.002740736,
0.02350252,
-0.015953388,
-0.014483645,
-0.008310726,
-0.024998985,
0.03254812,
0.008511146,
0.03342996,
-0.024838649,
-0.035193652,
0.021404795,
-0.0076293,
-0.02144488,
0.0063332543,
0.009880679,
0.0044092275,
-0.009079001,
-0.04484051,
0.015646078,
0.006433464,
0.037465073,
0.025386462,
0.005397964,
0.0005144099,
-0.022634035,
-0.007288587,
-0.00330024,
-0.013581757,
-0.012766718,
0.027550992,
-0.0043992065,
0.0073887967,
0.0099875685,
0.03503332,
-0.0021194357,
0.0000041427847,
0.0049737426,
-0.00020877025,
0.006453506,
-0.0012701582,
-0.022500422,
-0.0052342876,
-0.014871122,
-0.022019416,
-0.007094848,
-0.0031065014,
-0.012753357,
0.015365491,
0.00978715,
0.01751666,
-0.012639786,
-0.0040217503,
0.02267412,
-0.033109292,
0.0035407434,
0.041099347,
-0.025252849,
-0.010074417,
-0.0061461963,
0.0076025776,
-0.019747995,
-0.015098264,
0.014670703,
0.014804316,
-0.005969159,
-0.025546798,
0.013307851,
-0.012639786,
-0.016888678,
-0.000381632,
-0.02463823,
-0.008297365,
-0.016995568,
0.023141764,
-0.007515729,
0.011150002,
-0.0055415975,
0.009720343,
0.015512465,
0.008050181,
-0.01247277,
0.0024083736,
0.03094476,
0.019253628,
-0.026094612,
0.0017720419,
0.028887123,
-0.0033687167,
-0.00876501,
0.028272502,
-0.015124987,
-0.02792511,
-0.005731996,
-0.048180833,
0.011263573,
0.025119236,
0.0050572506,
-0.0152586,
-0.015793052,
0.0027875004,
-0.03455231,
-0.013147515,
0.008891943,
-0.005969159,
0.037812468,
-0.015245238,
-0.019347157,
-0.015966749,
-0.030490477,
0.016020194,
-0.0022547187,
0.04254237,
0.017663633,
0.010241433,
0.011484034,
-0.0004513613,
0.027951831,
-0.003824671,
0.017904136,
-0.008644759,
0.012232266,
-0.012526215,
-0.02351588,
0.027150154,
-0.022861177,
-0.00814371,
0.014710787,
-0.009092362,
-0.02896729,
0.013588438,
0.0097069815,
0.02763116,
0.008036819,
0.006032625,
-0.022286642,
-0.0063566365,
-0.005421346,
0.0005866444,
0.021404795,
-0.025493354,
0.010628911,
-0.0043758242,
-0.011383824,
0.013040625,
0.011724537,
0.024705036,
-0.035915162,
0.005144099,
0.01753002,
-0.00077203236,
0.02299479,
-0.036770288,
-0.02845956,
0.016167168,
-0.014189696,
0.017075736,
-0.008230559,
0.0066472446,
-0.03401786,
-0.02340899,
0.00071608194,
0.0037044194,
-0.031933498,
-0.0048234276,
0.0063699977,
0.01175794,
0.012312435,
0.010214711,
-0.011537479,
-0.004663092,
0.012840206,
-0.008430977,
0.029100902,
0.013534993,
-0.005638467,
-0.006109453,
0.03008964,
0.03372391,
0.0048334487,
-0.0056251055,
0.018639008,
-0.015499104,
0.00917253,
-0.0055516185,
0.01668826,
-0.0026889609,
-0.012091973,
0.013033944,
0.033456687,
0.0053378376,
-0.020295808,
0.0013069018,
-0.005351199,
-0.009493201,
0.0067975596,
-0.010575466,
-0.02669587,
-0.017449852,
0.0010455215,
-0.013274448,
-0.024798565,
-0.0047131972,
0.007876484,
0.006313212,
0.012773399,
0.02176555,
0.010528701,
-0.010395088,
0.0023766404,
-0.048261,
-0.005401304,
-0.02423739,
-0.0013770486,
0.010481937,
-0.011951679,
0.008263961,
-0.017169265,
0.013989277,
0.017075736,
0.020229002,
-0.011370463,
0.021925887,
0.0018271572,
0.0029361448,
-0.011731218,
-0.007308629,
-0.01720935,
-0.011691134,
-0.029635355,
0.019360518,
-0.00938631,
-0.010214711,
0.06734093,
-0.012332477,
-0.005508194,
-0.01030824,
-0.0032768578,
0.031318877,
-0.0014664022,
0.017543381,
-0.010501979,
-0.0059658187,
0.002331546,
-0.018692452,
-0.0025386463,
-0.060980953,
-0.010876095,
0.003981666,
0.020536313,
0.006102772,
-0.012686551,
0.0029144327,
-0.00628649,
-0.02422403,
0.0017703717,
0.0014213079,
0.007061445,
-0.0025035727,
0.014790955,
0.014189696,
-0.002443447,
-0.03586172,
-0.013454825,
0.034391977,
-0.0593776,
-0.012659828,
0.026308391,
-0.012405964,
-0.012258989,
-0.014710787,
0.0009403012,
0.0059624785,
0.0030730981,
0.0048334487,
-0.020977234,
0.012619744,
-0.03516693,
-0.006503611,
-0.0011782993,
-0.0195743,
-0.016354226
] |
Substantial changes are needed to achieve a more targeted and strategic approach to investment in the response to the HIV/AIDS epidemic that will yield long-term dividends. Until now, advocacy for resources has been done on the basis of a commodity approach that encouraged scaling up of numerous strategies in parallel, irrespective of their relative effects. We propose a strategic investment framework that is intended to support better management of national and international HIV/AIDS responses than exists with the present system. Our framework incorporates major efficiency gains through community mobilisation, synergies between programme elements, and benefits of the extension of antiretroviral therapy for prevention of HIV transmission. It proposes three categories | [
-0.007876232,
-0.015818762,
-0.0042662923,
-0.044817615,
0.01890826,
0.012835341,
-0.0062585548,
-0.0073591056,
-0.016083956,
-0.0029850786,
0.0017552461,
0.011250813,
0.00095303735,
0.007451923,
-0.008499435,
0.021427594,
0.044791095,
-0.014214344,
-0.002383422,
-0.022753559,
-0.037392214,
-0.013882853,
0.0197171,
-0.010097223,
-0.012702744,
0.010011036,
0.017675113,
-0.021772346,
-0.02917123,
0.0021298314,
0.009706063,
-0.0012232027,
0.0023519304,
-0.0037027572,
-0.015593348,
0.001039225,
-0.00179834,
-0.008035348,
0.029065153,
-0.020194447,
0.019955773,
0.011920425,
-0.008844187,
-0.002346958,
-0.009016562,
0.00255414,
0.018444173,
-0.010945841,
-0.02800438,
0.03373255,
0.012053021,
0.03373255,
-0.029303826,
0.010959101,
0.0068684984,
0.0062254057,
-0.010024295,
0.011999983,
0.0115027465,
-0.015540309,
-0.017330362,
0.010780095,
-0.040256295,
0.041423146,
-0.03182316,
0.0037193317,
0.02006185,
-0.0041668448,
0.01778119,
0.057812072,
0.055319257,
0.052826446,
0.0035005475,
0.027500514,
0.006056345,
-0.006175682,
-0.023323724,
-0.016866274,
0.026519299,
0.00548618,
0.014585615,
-0.007418774,
-0.029091671,
0.009991146,
0.009434241,
-0.0048231976,
0.007385625,
0.0310541,
0.018245278,
0.013180092,
-0.012079541,
-0.0006720985,
0.017144727,
0.02003533,
-0.016892795,
0.0055126995,
0.022912676,
0.004209939,
0.019637542,
-0.008433137,
-0.017197765,
-0.013829814,
-0.031902716,
-0.0050452966,
-0.0058110417,
-0.0053502684,
-0.0068552387,
0.01249722,
0.009904958,
-0.027341397,
-0.040362373,
0.03906293,
-0.007690597,
-0.03415686,
0.024039745,
0.010176782,
-0.010461864,
0.00085690484,
0.0056651854,
-0.0011892249,
0.0044751316,
0.013478434,
0.030232001,
0.0174497,
0.035854094,
-0.022753559,
-0.0196508,
-0.022249693,
0.003179001,
-0.013432025,
0.019915994,
-0.0017867378,
0.014930366,
0.01892152,
-0.021109363,
0.025007699,
-0.009765732,
-0.009374572,
-0.04537452,
-0.01589832,
0.009235346,
0.024013225,
-0.0181392,
-0.0018182294,
-0.004153585,
0.013896113,
0.032565698,
0.0044883913,
-0.0019823175,
0.010282858,
0.00984529,
-0.022475107,
0.001091435,
0.00046657393,
-0.0044187782,
0.007418774,
-0.017224286,
0.008101646,
-0.018006604,
0.016110474,
0.017635334,
-0.017661853,
0.0028856313,
0.038081713,
0.014346941,
0.0045115957,
0.023257425,
0.0028127031,
-0.006881758,
0.00063231954,
-0.0006816289,
0.015686166,
-0.0040441933,
0.010256339,
-0.0032486143,
0.033493876,
0.018722625,
0.028163496,
-0.01743644,
-0.017184505,
0.0009977886,
0.004849717,
0.011622083,
0.01778119,
-0.010296118,
-0.018006604,
0.01929279,
-0.005413252,
0.013498323,
-0.0056287213,
0.01287512,
0.0166276,
0.0054729204,
-0.00045372863,
-0.6419792,
-0.0065701567,
-0.0067955707,
-0.01699887,
0.013193351,
-0.010985619,
0.019239752,
0.012762412,
-0.027924823,
0.017542517,
-0.0058010966,
0.011429818,
-0.012629816,
-0.038002156,
-0.010316008,
-0.01588506,
-0.009328163,
-0.032061834,
0.023363503,
-0.00091823074,
0.00005220987,
0.01930605,
0.00871822,
0.006178997,
0.0008390872,
0.0044883913,
0.019372348,
-0.025710462,
-0.0046806564,
0.011396669,
-0.0048696063,
0.0076508177,
-0.01966406,
0.0061193286,
0.047363468,
0.0021662952,
-0.0066662887,
0.015792243,
0.025140297,
0.013113794,
-0.01022319,
-0.008678441,
0.024371237,
-0.00567513,
-0.014704952,
0.017264064,
0.015765723,
-0.022806598,
0.008035348,
-0.0074254037,
0.01548727,
0.0035038625,
-0.02685079,
0.0032618737,
0.020008812,
-0.022170134,
-0.008910485,
-0.036570113,
0.006692808,
0.0074055144,
0.007332586,
0.003633144,
-0.021043064,
-0.024769025,
-0.014545836,
0.018735886,
-0.020724833,
0.04309386,
-0.0041071763,
-0.0012836999,
-0.0011469597,
0.029728135,
-0.025233114,
-0.015381194,
0.012961308,
0.002002207,
0.0077834143,
-0.0060033062,
-0.02763311,
0.0015290034,
0.015420972,
-0.008890595,
-0.020393342,
-0.0079359,
0.010647499,
-0.011157995,
-0.010833134,
0.0015099426,
0.0004417121,
0.014665172,
0.02118892,
-0.001228175,
0.0060033062,
-0.029966809,
-0.011900536,
0.025843058,
-0.00066878356,
0.01324639,
0.002612151,
-0.012092801,
-0.013432025,
-0.018643068,
0.001505799,
0.005118225,
0.00074626965,
0.011330371,
-0.02877344,
0.008048607,
0.04741651,
-0.023058532,
-0.0153016355,
-0.006056345,
-0.01815246,
-0.010548051,
0.0016176773,
-0.031107139,
0.0033298295,
0.0052342466,
0.0075845197,
-0.0142276045,
0.011549155,
0.004538115,
0.01969058,
-0.014240864,
0.008154685,
0.016945831,
0.010488383,
-0.029197749,
-0.015725944,
0.0028243053,
0.0009522086,
-0.017847488,
0.02118892,
0.0060364557,
0.018006604,
-0.0045447447,
0.012788932,
-0.009566837,
-0.016601082,
-0.03336128,
0.0027911563,
-0.0064773387,
0.0020519309,
-0.004620988,
-0.011781199,
-0.016786717,
-0.0018845277,
-0.0035071773,
0.003948061,
-0.005293915,
-0.009387832,
-0.012908269,
-0.020088369,
0.00274309,
0.013418766,
-0.018324835,
-0.0018762405,
-0.047867335,
0.0014187825,
-0.0103624165,
-0.0022243063,
0.003364636,
0.0052010976,
0.005950268,
-0.014651913,
-0.00021774831,
0.007975679,
0.019637542,
-0.009653025,
-0.028136976,
0.007637558,
-0.029277306,
-0.020194447,
0.042589996,
-0.0034243045,
0.021069583,
-0.0019441962,
-0.011887276,
-0.0066165654,
0.00052955723,
-0.00872485,
-0.007312697,
-0.009699434,
-0.0010127057,
0.012298325,
0.0018298316,
-0.004246403,
0.009241976,
0.014784509,
0.008950263,
-0.0016168485,
-0.0065635266,
-0.011635343,
0.011847497,
-0.009394462,
0.009261865,
-0.012278436,
0.007491702,
0.0035734756,
0.02193146,
0.031955756,
-0.02763311,
0.010090593,
0.000800137,
-0.0044088336,
-0.0006186455,
-0.0010773465,
-0.015394453,
0.015991138,
0.009546948,
0.015792243,
-0.026598858,
-0.015977878,
0.011045288,
-0.023867369,
0.015659647,
-0.0032055203,
0.026148029,
-0.01213921,
0.017091688,
-0.015765723,
0.011018769,
0.007862972,
-0.019836435,
-0.018788924,
-0.009241976,
-0.0009414351,
0.031266253,
0.005748058,
-0.0014577328,
-0.0010325952,
0.013882853,
0.005880655,
0.014784509,
0.010693908,
-0.004246403,
0.00910275,
-0.017622074,
0.035615418,
0.005516014,
0.012192248,
0.006706068,
0.0101701515,
0.026532559,
0.018245278,
0.0005245849,
0.04171486,
0.037657406,
-0.01514252,
0.03410382,
-0.026161289,
0.008360209,
0.0035867353,
-0.015076222,
-0.0029204378,
-0.000115296796,
0.0010707168,
0.026426481,
0.027155763,
0.04248392,
0.018404394,
0.019531464,
0.011476227,
-0.010475123,
-0.006550267,
-0.0069878353,
-0.014346941,
-0.013683959,
0.0040740273,
0.014970144,
-0.00034433653,
-0.015659647,
0.01892152,
-0.026811011,
0.00217624,
0.00872485,
-0.0009919875,
-0.005970157,
-0.0056121466,
-0.0033729235,
-0.011045288,
-0.0068751285,
0.031690564,
0.0018364615,
-0.00095469475,
-0.027553553,
-0.0010723742,
0.015818762,
-0.016534783,
0.0058839694,
-0.012066281,
-0.008201093,
-0.0016400529,
-0.00063149084,
-0.00071022,
-0.027049685,
0.027288359,
-0.025312671,
-0.005313805,
-0.0005337009,
0.01664086,
0.0028607694,
-0.0026220956,
-0.010654128,
0.046833083,
-0.0033182274,
-0.014307162,
-0.025644163,
-0.01783423,
-0.022355769,
0.030629791,
-0.0017436439,
0.008419878,
0.00004198026,
0.028083937,
0.009580097,
-0.024503833,
0.024702728,
0.009739213,
-0.010793355,
0.01401545,
-0.039566796,
-0.0011618768,
-0.005002203,
0.08703634,
0.008220983,
-0.0059966766,
0.008632032,
0.017675113,
0.02763311,
0.006520433,
-0.022156876,
0.027394436,
-0.021785604,
-0.00068950176,
0.0057845223,
0.022594443,
-0.00010638797,
0.013372357,
0.028322611,
-0.015169039,
-0.0025657422,
0.0023088364,
0.01099888,
0.01625633,
-0.0040077292,
0.030444156,
0.0409458,
0.003593365,
-0.00085690484,
0.022965712,
0.006401096,
0.0040740273,
-0.019107156,
-0.0007280376,
0.005449716,
0.013790036,
0.048530318,
-0.032008793,
-0.038055196,
-0.008817667,
-0.01626959,
0.029303826,
0.0037723703,
0.025034219,
0.008751369,
0.009036452,
0.0052077277,
-0.012444181,
0.011317111,
-0.013451914,
0.0153679345,
0.006023196,
-0.009891699,
0.017993344,
-0.008598883,
-0.045294963,
0.005419882,
0.014903846,
-0.00417016,
-0.028959075,
0.0050983354,
-0.012165729,
-0.02572372,
-0.03442205,
-0.021454113,
0.0196508,
-0.027898302,
-0.010906062,
0.0016309369,
-0.010276228,
0.019703839,
-0.0065436373,
-0.007902752,
0.0024331457,
-0.027129244,
-0.005446401,
0.01664086,
-0.0022839746,
0.012424292,
0.022753559,
-0.004196679,
-0.0041038617,
0.009931478,
-0.019054117,
-0.016746938,
-0.013319318,
-0.026784493,
0.0064607644,
0.0068022003,
0.0012389485,
-0.035429783,
-0.0317436,
0.029622057,
-0.013180092,
-0.0026237532,
0.017290583,
0.0060729194,
-0.036888346,
0.008393358,
0.021838643,
0.01138341,
-0.0019723729,
-0.018457433,
-0.0042994414,
-0.016733678,
-0.010156891,
-0.031557966,
0.010448604,
-0.013988931,
0.0025624274,
-0.008247502,
-0.019014338,
-0.03588061,
0.02276682,
-0.025286153,
-0.0006617394,
0.0014395007,
0.020618755,
0.0004781761,
0.035350226,
0.011085067,
0.026811011,
0.003742536,
-0.019266272,
-0.010853023,
0.0069812057,
0.038452983,
-0.017648594,
0.0038121494,
0.022674002,
-0.014638653,
-0.025140297,
0.007862972,
-0.012649706,
0.049246337,
-0.0012198878,
-0.01815246,
-0.012430921,
0.0037756853,
-0.016203292,
-0.0037790001,
0.0025906041,
-0.026148029,
0.004432038,
-0.0174497,
-0.004793363,
-0.031107139,
0.031107139,
-0.033891663,
-0.009573467,
0.019425387,
-0.009812141,
0.01211269,
-0.017515996,
0.00018915719,
-0.019253012,
0.021918202,
-0.01552705,
-0.02917123,
0.01138341,
-0.013882853,
0.018006604,
0.039540276,
0.025034219,
-0.018245278,
-0.013206611,
0.015659647,
0.021785604,
-0.013790036,
-0.0026784493,
-0.016004397,
-0.016495004,
0.03643752,
0.0317436,
0.009885069,
-0.026214328,
-0.032777853,
0.026201067,
0.0010665731,
-0.020380082,
-0.02917123,
-0.035323706,
-0.006725957,
0.0030894985,
0.00417016,
0.003182316,
-0.007882861,
-0.06847283,
0.0181392,
0.02120218,
0.005264081,
0.02238229,
-0.0030745813,
0.0073922547,
0.002968504,
-0.0055756825,
0.012271806,
-0.0011850812,
-0.006782311,
-0.0028392226,
-0.026678415,
0.0013433683,
0.0117546795,
-0.005522644,
-0.00435248,
0.011522636,
-0.020897208,
0.020963507,
0.023549138,
-0.01514252,
0.0019392237,
-0.0028160182,
-0.032061834,
-0.010090593,
-0.010939211,
-0.031982277,
-0.03405078,
0.007916011,
-0.0067557916,
-0.009692804,
0.009255235,
-0.0070806528,
0.003865188,
0.00046533084,
-0.004763529,
0.005194468,
-0.03972591,
0.009672915,
0.00039716795,
-0.013074014,
-0.01782097,
-0.0074718124,
0.002292262,
0.005456346,
0.025988914,
0.008247502,
-0.030417636,
-0.00029564876,
0.003175686,
0.034660723,
0.009493909,
-0.02874692,
0.02650604,
0.0116287125,
0.018629808,
0.0010011035,
-0.032406583,
-0.025856316,
0.031611007,
0.0111845145,
0.00026912946,
-0.0052740257,
-0.016786717,
-0.013001086,
0.017953565,
-0.0061955713,
0.004316016,
0.010846393,
-0.027686149,
-0.003676238,
-0.023655215,
-0.010262969,
0.003273476,
0.0021629804,
0.022859637,
0.011834238,
0.012132579,
0.0017701632,
-0.00073010946,
-0.0032220948,
0.0071999896,
0.008857446,
0.026718194,
-0.018271796,
0.00473038,
0.019637542,
-0.013670699,
0.0052176723,
0.009268495,
0.007458553,
-0.008499435,
-0.03291045,
-0.00071477797,
0.008864076,
0.018709365,
-0.008592253,
-0.006178997,
0.0053502684,
0.012788932,
0.008771258,
-0.018643068,
0.012159099,
-0.00045870102,
-0.015195559,
-0.0020104945,
0.0024828694,
0.03816127,
0.0025922614,
-0.0042596627,
0.008738109,
0.01855025,
-0.03744525,
0.005937008,
0.03519111,
0.00039385303,
-0.013093904,
0.01815246,
-0.024914881,
-0.0073988847,
0.0087115895,
-0.010693908,
-0.028216535,
0.0057745776,
-0.004206624,
0.012788932,
0.008572363,
0.005419882,
0.014996664,
-0.0042132535,
-0.00041788616,
-0.007465183,
-0.030948022,
0.02232925,
-0.015169039,
-0.004432038,
0.042987786,
-0.040627565,
0.041555744,
-0.0024165711,
0.020658534,
-0.0023138088,
-0.02498118,
-0.01172153,
-0.010083963,
0.014970144,
-0.023058532,
-0.010435345,
0.0060397703,
-0.016203292,
-0.0056552407,
0.0009430926,
0.00084405957,
0.00047900484,
-0.0073259566,
-0.018788924,
-0.0023751347,
0.0028640844,
-0.019226491,
-0.000633977,
-0.000813811,
-0.011820978,
-0.023920408,
-0.00719336,
-0.018749144,
0.025140297,
0.021096103,
-0.013418766,
-0.0062187756,
0.0041999943,
-0.05112921,
0.007451923,
-0.002877344,
0.022992233,
0.009334793,
0.021493893,
0.023814332,
0.018324835,
0.016216552,
0.020751351,
-0.013697218,
-0.014254124,
0.0108066145,
-0.013060755,
0.0056254063,
-0.012404403,
-0.036888346,
-0.00016046248,
0.04248392,
0.0090298215,
0.008479546,
0.020366821,
0.011462967,
-0.009546948,
0.009573467,
0.023310464,
-0.010335897,
0.0015546939,
0.0016011028,
-0.023323724,
-0.011588934,
0.024172341,
0.0077502653,
-0.0022093891,
0.0115027465,
-0.019465165,
0.0033480616,
0.015407713,
-0.01740992,
-0.008824297,
0.016110474,
-0.034952436,
0.0056685004,
-0.001115468,
0.029993327,
0.008366839,
0.019001078,
0.016481744,
0.021878421,
0.019226491,
-0.03227399,
-0.004057453,
0.013949151,
-0.0077834143,
-0.01096573,
-0.00681546,
-0.0035668458,
0.011807718,
0.013776776,
-0.0011759652,
-0.016428705,
-0.012556888,
0.0069745756,
-0.016428705,
-0.019146934,
-0.006676234,
0.0027082835,
0.00088093797,
-0.031107139,
-0.02043312,
0.011781199,
-0.017887268,
0.009328163,
-0.009818771,
-0.009328163,
-0.015606607,
0.005903859,
0.008844187,
-0.0052475063,
0.025776759,
0.19868259,
0.0018298316,
0.030948022,
-0.0055823126,
-0.025922615,
0.011575675,
0.037710443,
0.0028856313,
-0.0030563492,
0.04049497,
-0.010640869,
0.010912692,
-0.004959109,
0.0041303807,
-0.029622057,
-0.0295425,
-0.046408772,
0.015778983,
-0.021679528,
0.013014346,
0.027420955,
0.01706517,
0.0072198794,
-0.00417679,
0.025869576,
-0.00088673906,
-0.025405489,
0.0012505507,
0.022634221,
-0.0062718145,
-0.0087115895,
-0.026240846,
-0.029940289,
0.016150253,
0.013571251,
-0.023217646,
-0.015964618,
-0.01589832,
-0.0029005483,
-0.008539215,
-0.0079359,
0.047363468,
-0.03481984,
-0.024013225,
0.018749144,
0.009533688,
-0.016428705,
-0.025312671,
-0.013352468,
-0.0018563509,
-0.012696114,
-0.010495013,
0.0042132535,
0.024742506,
-0.016786717,
0.01588506,
0.010945841,
-0.013040866,
-0.011264073,
0.027473994,
-0.010508273,
-0.006172367,
0.011257443,
0.008466287,
-0.005018777,
0.025392229,
-0.030205483,
-0.0067160125,
0.0189613,
-0.0065801013,
-0.0066033057,
-0.014466278,
-0.005118225,
0.02459665,
-0.016786717,
-0.008744739,
0.02382759,
0.0013425396,
0.03603973,
0.009931478,
-0.004140326,
-0.026081732,
-0.011953575,
0.015036443,
0.00091740204,
-0.025166815,
0.0057812072,
0.019160194,
-0.008161315,
0.004988943,
0.009381202,
0.0061126985,
-0.02307179,
-0.013034236,
0.004952479,
0.0035469562,
0.0013964069,
0.0016359093,
-0.005363528,
-0.014360201,
-0.013392246,
0.07743636,
-0.0076176687,
0.0019624282,
0.0077767847,
-0.017224286,
-0.018404394,
0.0041668448,
-0.0046010986,
-0.020578977,
0.0113767795,
-0.03182316,
-0.0012455784,
-0.026426481,
0.017688373,
0.018841961,
0.0062983334,
-0.012603297,
0.026174549,
-0.0034541388,
-0.006381206,
-0.025670681,
0.0027662944,
0.004153585,
-0.0057712626,
-0.009248606,
-0.012205508,
-0.010461864,
-0.012536999,
-0.024411015,
0.027951341,
-0.015062962,
0.0015430917,
-0.0019011023,
0.0052408767,
-0.0053535835,
-0.013306059,
-0.0083138,
-0.0030497194,
0.008055237,
-0.009546948,
0.0027381177,
0.00293204,
0.0045248554,
0.010077334,
-0.021918202,
0.010289488,
0.015593348,
0.0020287265,
0.012908269,
-0.026771232,
0.009971256,
0.010103853,
-0.038850773,
0.0050287223,
-0.002499444,
0.0039944695,
-0.016362408,
0.01706517,
0.014744731,
-0.03715354,
0.0131469425,
0.039195526,
-0.0068220897,
-0.0144795375,
0.025392229,
-0.16728374,
0.021427594,
0.020340303,
-0.011774569,
0.031690564,
-0.016879534,
0.020154668,
0.0077502653,
-0.009215456,
0.013949151,
0.028057419,
0.0015008266,
-0.03908945,
-0.016428705,
0.0037292766,
-0.020287264,
-0.043756843,
0.022514885,
0.014307162,
0.0061823116,
0.015182299,
-0.022435328,
0.0025342505,
-0.0066397698,
0.014267383,
0.008181204,
-0.01249059,
0.008492806,
-0.028614324,
-0.019372348,
-0.007087283,
-0.00013093904,
0.057652958,
-0.020525938,
-0.0036165696,
-0.0059635276,
-0.024079524,
-0.0030729237,
-0.006122643,
0.0018480637,
0.039169006,
0.011157995,
0.011489486,
-0.0041999943,
-0.023217646,
0.034607686,
0.025498306,
-0.0080154585,
-0.012981197,
-0.0030762388,
0.010667388,
0.0059966766,
-0.005598887,
0.0070209843,
0.0181392,
-0.012430921,
-0.0008436452,
-0.00417016,
0.0102033,
0.0017602185,
-0.03402426,
0.009573467,
0.023535877,
-0.013127053,
0.0063546873,
-0.041131433,
-0.01851047,
0.012822081,
-0.0147977695,
0.029409904,
-0.045268442,
0.010548051,
-0.0119469445,
-0.020274004,
0.0024546927,
0.012808822,
-0.024702728,
0.02499444,
-0.0012687828,
-0.015195559,
-0.0010649157,
0.034740284,
-0.004574579,
0.0060397703,
0.014453018,
-0.016746938,
0.008578993,
0.015062962,
0.0026204383,
-0.016866274,
0.019531464,
-0.029781174,
0.014678433,
-0.006699438,
0.0019524834,
0.024344716,
0.020738091,
0.009361313,
0.0101701515,
0.024570132,
0.0063016484,
0.005337009,
-0.019160194,
0.017595556,
0.009984517,
-0.016574562,
-0.005754688,
0.018391134,
0.04956457,
0.010853023,
-0.028322611,
0.03680879,
0.0021778974,
0.025286153,
0.00908286,
0.025882836,
0.00016926772,
-0.015089481,
0.018245278,
-0.015500531,
0.044870656,
-0.008512695,
-0.031160178,
-0.010176782,
-0.02800438,
-0.018298317,
-0.12962633,
-0.0049789986,
0.008095016,
0.0022027593,
0.013345838,
0.035482824,
0.029303826,
-0.017303843,
-0.04020326,
0.011191145,
-0.051739153,
-0.029701615,
-0.016163513,
0.00907623,
0.029462941,
-0.009155788,
-0.006483969,
-0.01323976,
-0.017993344,
0.022846377,
0.011224293,
-0.03214139,
0.0062353504,
-0.017555777,
0.010057445,
0.021454113,
-0.0159381,
-0.00032900507,
0.024371237,
0.014585615,
0.0063082785,
-0.016932573,
0.027447475,
-0.01592484,
-0.00053411524,
-0.011151365,
-0.03527067,
-0.007657448,
0.015646387,
-0.006725957,
-0.004604413,
0.02723532,
0.010707167,
-0.02572372,
0.024901623,
-0.010256339,
0.008897225,
0.0035867353,
0.016773457,
-0.016190032,
-0.042696074,
-0.012304955,
-0.034952436,
-0.0102033,
0.0018248593,
-0.00075124204,
0.0029585594,
0.008393358,
0.0068419795,
0.0008726507,
-0.006553582,
0.004282867,
-0.008439767,
0.004843087,
0.033493876,
-0.008877335,
-0.022567924,
0.004584524,
0.009765732,
-0.015394453,
-0.006586731,
-0.008413248,
-0.030178962,
0.0025093886,
-0.029754654,
0.008472916,
-0.01740992,
-0.025869576,
0.025630902,
0.010607719,
-0.025882836,
-0.029277306,
0.008386728,
-0.010455234,
0.00237182,
0.008466287,
0.013776776,
-0.014890587,
-0.014506057,
-0.011966834,
0.003440879,
0.028826479,
0.0029386699,
-0.03028504,
0.00022727868,
0.017237544,
0.008002198,
-0.013670699,
0.0077900444,
0.036994424,
-0.03513807,
0.018987818,
-0.040150218,
0.01775467,
0.010654128,
-0.011171255,
-0.0072928076,
-0.020340303,
-0.008181204,
-0.0071668406,
-0.002499444,
-0.022289472,
-0.008877335,
0.016123734,
0.00087016454,
0.0166276,
-0.024119303,
-0.009394462,
0.015593348,
-0.026532559,
0.0018182294,
0.02423864,
-0.015354674,
0.0004922645,
0.017555777,
0.014254124,
0.020751351,
0.0030911558,
-0.0050519267,
0.00340773,
-0.005502755,
0.007074023,
0.011025399,
-0.019199973,
-0.02535245,
0.010495013,
0.0074452935,
-0.0070806528,
0.0047900486,
0.015447492,
0.004693916,
0.03296349,
-0.021493893,
-0.007432034,
-0.018788924,
-0.032061834,
-0.009188937,
0.018470692,
-0.03301653,
0.0125767775,
0.009533688,
-0.02384085,
0.030019848,
0.008930374,
-0.024517093,
-0.0058077266,
-0.022408808,
-0.007312697,
0.014665172,
-0.0038386686,
-0.015991138,
-0.0153679345,
0.005449716,
0.008466287,
-0.022117095,
-0.009394462,
0.012536999,
-0.019266272,
-0.011462967,
-0.0033679511,
0.013591141,
-0.009195567,
-0.02346958,
-0.013332577,
0.00041415688,
0.0072463984,
-0.011283962,
0.00020946102,
0.016932573,
-0.011111586,
0.004690601,
0.005937008,
-0.00014958542,
-0.0035336968,
-0.013120423,
0.023363503,
0.015818762,
-0.016720418,
-0.01702539,
0.04235132,
-0.0141613055,
-0.0058441907,
-0.0050784457,
0.018404394,
-0.014930366,
0.0016740308,
0.017489478,
0.014784509,
0.016110474,
0.017595556,
0.017555777,
0.021865163,
-0.011429818,
0.005588942,
0.014612134,
-0.024318198,
-0.020128148,
0.0081414245,
-0.01933257,
-0.013776776,
-0.015765723,
0.009885069,
-0.0034673985,
0.0018414338,
0.012676225,
-0.005141429,
-0.019239752,
0.012716004,
-0.0038353538,
-0.0060795494,
-0.023350243,
0.021812124,
0.024702728,
0.013935892,
-0.003716017,
-0.0014138102,
0.015208818,
0.004607728,
-0.012662966,
-0.022355769,
0.0147314705,
0.021056324,
-0.006590046,
0.009003302,
-0.018868482,
-0.0073392163,
-0.01323976,
-0.03553586,
0.024742506,
0.01060109,
0.005264081,
0.040256295,
0.0053867325,
-0.00548618,
-0.0029204378,
0.009261865,
0.015672905,
-0.0070209843,
0.00005697506,
-0.019067377,
-0.013935892,
0.019544724,
-0.017966826,
-0.001682318,
-0.046647448,
-0.0056585553,
0.029436423,
-0.017675113,
0.017953565,
-0.034236416,
0.011509376,
0.03821431,
0.016402187,
0.008764628,
-0.0007019327,
-0.019969033,
-0.0043226457,
0.002139776,
0.002670162,
0.011429818,
-0.028640844,
-0.015288376,
-0.0017237545,
-0.011091697,
-0.03436901,
0.0078298235,
-0.0022756874,
-0.00019330083,
0.012417662,
0.012357994,
0.009566837,
0.013803296,
0.028932557,
-0.01664086,
-0.036145806,
-0.025432007,
-0.0069082775,
-0.026081732,
-0.024875103,
-0.024769025
] |
T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF- α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics | [
-0.023334684,
0.017360289,
-0.007880573,
-0.026098002,
-0.00805328,
-0.0032974312,
-0.034260023,
0.01129634,
-0.016899735,
-0.015390145,
0.011494635,
-0.005050091,
-0.018741947,
-0.0013928529,
-0.012799534,
0.013112966,
0.035539337,
0.019586293,
0.0010146557,
-0.0022228076,
-0.027505247,
0.012646017,
0.0073048817,
-0.0026225932,
-0.006124715,
0.00028444742,
0.006297422,
-0.048895374,
-0.02699352,
0.0001620131,
0.01573556,
-0.0077078654,
-0.005216402,
-0.015275006,
0.0072345193,
-0.024588412,
0.01133472,
-0.016912527,
0.029756838,
0.01312576,
0.017808048,
0.0006556483,
-0.0056065926,
-0.0037068117,
0.012486102,
0.015275006,
0.011117237,
-0.007311278,
0.0024163038,
0.027786694,
0.034183264,
-0.00010964119,
-0.0169637,
-0.0135223465,
-0.03049884,
-0.001045839,
-0.006722794,
0.023066027,
-0.015390145,
-0.03008946,
-0.00762471,
-0.015121489,
-0.012780345,
-0.013189725,
-0.005475463,
0.011053271,
-0.010368838,
0.036588375,
0.001096212,
0.0022963681,
0.02156923,
0.038712036,
-0.011142823,
-0.0031615042,
0.008769696,
-0.018997809,
-0.019189706,
-0.0002048901,
-0.02625152,
-0.003956278,
0.020814436,
-0.025215274,
-0.01802553,
0.019381603,
0.0096268365,
-0.008814472,
-0.0012481305,
0.018869879,
0.011590583,
0.00011004097,
0.004135382,
0.00056369766,
0.010183338,
0.04293377,
-0.00015501685,
0.0055969977,
0.014123624,
0.025995657,
-0.016490355,
-0.024396515,
-0.0084114885,
0.01004901,
-0.0030287753,
-0.014558591,
-0.043394323,
-0.0063453964,
0.005216402,
0.0047814352,
0.02531762,
-0.0060639475,
-0.023245132,
0.028605456,
0.007918952,
-0.051761035,
0.020443434,
0.0037739757,
0.0040970026,
0.0036140615,
-0.015108695,
-0.015761146,
0.01282512,
0.026686486,
0.0140468655,
-0.0077334517,
0.012236636,
-0.007893366,
0.0034477506,
-0.014085244,
-0.018319773,
-0.007496779,
0.009997837,
-0.012837914,
0.020149192,
0.004787832,
0.00035640883,
0.0057441187,
-0.01349676,
-0.01675901,
-0.0090383515,
-0.0040330365,
0.00045295703,
0.028144903,
0.005689748,
0.006582069,
0.015940249,
-0.0034477506,
0.026149174,
0.007285692,
-0.00533154,
0.021927439,
-0.011731307,
-0.021863472,
0.023513786,
-0.00009369974,
0.0032334656,
0.000009369974,
-0.029987115,
0.035539337,
-0.009147094,
-0.0023475408,
0.021466885,
-0.03310864,
0.029117182,
0.013266484,
0.03228988,
0.015121489,
-0.00244189,
0.03277602,
0.002305963,
0.015646007,
-0.012735569,
0.02095516,
0.008571402,
0.017155597,
-0.015390145,
0.01724515,
-0.01569718,
0.009697199,
-0.014277142,
-0.028451938,
0.009812336,
0.020699296,
0.03935169,
-0.004106597,
-0.01463535,
-0.0057313256,
0.041270662,
-0.0056385756,
-0.0029296286,
0.0005401103,
0.021658782,
0.013317657,
0.006614052,
-0.036025476,
-0.6361772,
-0.023871996,
0.025752587,
0.00488378,
0.000041003004,
0.024754722,
-0.012031946,
-0.015620422,
-0.034822922,
-0.001910975,
-0.0063421982,
0.008469057,
0.028810145,
-0.019356018,
-0.009044749,
-0.033134226,
-0.034387954,
-0.024652377,
0.011526617,
-0.000171508,
-0.003892312,
-0.0014104435,
-0.0009610845,
0.007771831,
-0.008827265,
0.008635368,
0.0075159683,
-0.007535158,
-0.00037399938,
0.04382929,
-0.019151328,
0.015390145,
-0.009121507,
0.0012377361,
0.038916726,
0.017168391,
-0.009901889,
0.027172625,
0.009857113,
0.03351802,
-0.020558573,
-0.02140292,
0.00025106533,
-0.012140688,
-0.017680116,
0.018294187,
0.00456715,
0.013010621,
0.0058080847,
-0.02544555,
0.00337419,
0.008571402,
-0.0011809665,
0.011456255,
0.015965836,
-0.01977819,
0.02283575,
-0.000026535767,
-0.0020149192,
-0.008718523,
-0.016810182,
0.038277067,
-0.034797333,
-0.007074605,
-0.0143539,
0.0024946618,
-0.002606602,
-0.019765398,
0.0091023175,
0.014609763,
-0.02030271,
0.032238707,
-0.016017009,
-0.007880573,
0.014673729,
0.028196076,
-0.005485058,
0.012089515,
-0.004071416,
0.008731317,
-0.008149229,
-0.007918952,
0.00018220226,
0.017296322,
0.015607628,
-0.007650296,
-0.00807247,
0.021722747,
-0.010074596,
0.009697199,
0.01965026,
0.005868852,
-0.010893357,
-0.041398592,
-0.03254574,
0.034439128,
-0.009511698,
0.0030383703,
-0.0063421982,
0.0019637467,
0.0023523383,
-0.00852023,
0.01634963,
0.008475454,
0.009275025,
0.011488237,
-0.054703455,
0.0021764326,
0.03907024,
-0.025663035,
0.010368838,
0.007388037,
-0.021582024,
0.0018837895,
0.011744101,
-0.012294206,
0.016196113,
0.023462614,
0.005162031,
-0.014379486,
0.038200308,
-0.0028368784,
0.02625152,
0.00024386919,
-0.011021288,
0.014520211,
-0.00017230757,
-0.012876294,
-0.01090615,
-0.020635331,
0.00850104,
-0.0011753695,
0.013420002,
-0.012089515,
0.014801661,
-0.0062270598,
0.04168004,
-0.00479103,
-0.008002108,
-0.03049884,
-0.019215293,
-0.031854913,
0.0029072405,
-0.01761615,
-0.00305756,
0.0117632905,
-0.007375244,
-0.0092494385,
0.0076950723,
-0.01194879,
-0.0017942375,
-0.005782498,
-0.03249457,
0.015070316,
0.034643818,
0.0004957341,
-0.0075607444,
-0.0059967833,
0.0023235537,
-0.02421741,
-0.011603376,
0.010503166,
0.021978611,
0.011181203,
-0.024997791,
0.010074596,
-0.0034733368,
0.035027612,
0.0033645951,
-0.036230166,
-0.015773939,
0.009217456,
-0.029449804,
0.025611863,
0.021236608,
-0.0064477413,
-0.02421741,
-0.009569267,
0.011859239,
-0.0075287614,
-0.021236608,
0.006614052,
0.010848581,
-0.01524942,
0.010196131,
-0.008533023,
0.022899717,
0.016439183,
-0.0036940186,
0.038993485,
0.004714271,
0.0036044666,
0.0066588284,
0.034515887,
0.009434939,
0.0011817662,
-0.00007266102,
0.009761164,
0.0074583995,
0.0087249195,
-0.016643872,
-0.0047174697,
0.011609772,
-0.043112874,
0.012031946,
-0.03339009,
0.010650287,
-0.019036189,
0.021594817,
0.006869915,
0.0066716215,
-0.028247248,
-0.012159877,
0.01778246,
0.011705721,
0.011200392,
0.0034893283,
0.0032782415,
0.016643872,
-0.034439128,
0.0063166115,
-0.003655639,
0.0085586095,
-0.0025330412,
-0.0077654347,
0.0074711926,
0.029296285,
0.009607647,
0.0051364447,
-0.004464805,
-0.005868852,
-0.014942385,
0.010183338,
-0.0032702459,
0.02319396,
-0.002158842,
0.0007495979,
-0.021786714,
0.015607628,
0.004448814,
0.0015751551,
0.010388028,
0.010688666,
0.0029536157,
0.004426426,
-0.0051684277,
0.018665189,
0.0011090052,
-0.0036332512,
0.019624673,
-0.021057505,
0.017577771,
-0.014865626,
-0.0091662835,
-0.013906141,
-0.012217446,
-0.0018789921,
0.005766507,
0.038635276,
0.004151373,
0.0292707,
-0.015441317,
-0.005184419,
-0.002270782,
-0.016912527,
0.013663071,
-0.016004216,
-0.0044903914,
0.0010490373,
-0.009287818,
-0.040451903,
0.023475409,
0.00786778,
-0.03029415,
0.018562842,
0.026814416,
0.023641719,
0.0057313256,
0.009933871,
0.011891222,
0.0015135881,
-0.008840058,
0.024882654,
0.031087324,
-0.0028080938,
-0.001979738,
-0.021748334,
-0.015837904,
-0.01439228,
0.00087872864,
-0.01651594,
0.038046792,
0.026021242,
-0.0012889087,
0.008059677,
0.013765416,
0.02438372,
-0.028631043,
0.006575673,
-0.0003212277,
0.0077334517,
-0.020648124,
-0.01306819,
-0.0063006203,
0.039965764,
0.020110812,
-0.0038763208,
-0.013176932,
-0.028042559,
-0.017283529,
-0.0012073524,
-0.010803805,
-0.0013208914,
-0.00085634063,
0.00073160755,
0.0077206586,
0.017437046,
0.029603321,
0.021722747,
-0.028247248,
-0.007688676,
-0.038405,
0.012754758,
-0.006163094,
0.023424236,
0.020405054,
0.006882708,
0.0056833513,
0.017744083,
-0.010093786,
-0.019048981,
-0.031292014,
0.023680098,
-0.027786694,
-0.018575637,
-0.00079597306,
0.002216411,
-0.003994657,
-0.00980594,
0.030857049,
0.010637494,
-0.007835797,
0.01965026,
0.0015239825,
0.007682279,
0.026840003,
0.027505247,
0.0057761017,
0.027172625,
-0.0092494385,
-0.008705731,
0.022093749,
-0.00055730104,
-0.01855005,
-0.010759029,
0.0052803676,
0.0040650195,
0.0005529034,
-0.0052483846,
-0.021211023,
-0.01224943,
0.003508518,
0.010381632,
0.00015151873,
0.018562842,
0.017603358,
0.014110831,
-0.0025250455,
-0.01724515,
0.0069210874,
0.00034261623,
0.006895501,
-0.011840049,
-0.002520248,
0.0077974177,
-0.020980746,
-0.0019253673,
-0.028247248,
-0.007835797,
-0.0017030864,
-0.017014874,
0.00017310714,
-0.0030735515,
-0.011935998,
-0.0064029656,
-0.029347459,
0.029910356,
0.009876302,
-0.015812319,
-0.029117182,
0.0008555411,
-0.00568655,
-0.023424236,
-0.006889105,
0.020993538,
-0.02393596,
-0.010362442,
0.011481841,
0.0045607537,
0.003879519,
0.011891222,
-0.008078867,
-0.0032126766,
0.024281375,
-0.0067995526,
-0.018857084,
0.024972204,
-0.029168354,
0.015812319,
0.0053251437,
0.020801643,
-0.0101065785,
-0.014174797,
-0.0054722647,
-0.0074520027,
-0.029296285,
0.016055388,
0.012083119,
-0.012812328,
0.021518057,
0.034311194,
-0.011533014,
-0.034925267,
-0.018524464,
-0.03942845,
-0.01977819,
-0.014571384,
0.0015311787,
0.009850716,
-0.013407208,
0.021313367,
0.014225969,
-0.022413578,
-0.018729154,
0.02580376,
0.00002923432,
0.007042622,
0.00676757,
-0.008449867,
0.028170489,
-0.00023987133,
0.006703604,
0.03228988,
-0.022080956,
-0.014264349,
-0.0043880465,
-0.00063046184,
-0.018447705,
-0.03633251,
-0.014558591,
0.0069338805,
-0.034669403,
-0.0097099915,
-0.000003885416,
-0.01838374,
0.01989333,
-0.009837923,
-0.012198257,
-0.033492435,
0.0069466736,
-0.01135391,
0.025816552,
0.00054450793,
-0.02112147,
-0.015108695,
0.0074136234,
-0.026916761,
0.0012633223,
0.0024306963,
-0.03234105,
-0.005948809,
0.026481796,
0.02026433,
0.014174797,
-0.0068187425,
-0.0031439136,
-0.020545779,
-0.0060223695,
-0.0135223465,
-0.023705684,
0.0033773885,
-0.018665189,
0.042089425,
0.015812319,
0.022643853,
-0.023296304,
0.03674189,
0.0029328268,
-0.0030959393,
0.019356018,
-0.014545797,
0.010912547,
-0.02507455,
0.019522328,
0.0065276986,
-0.004886979,
0.009147094,
-0.017769668,
0.005491454,
0.031087324,
0.0023299502,
-0.0051172553,
0.0072920886,
-0.032929536,
-0.025432758,
0.016682252,
0.004563952,
0.012556464,
-0.015786732,
-0.0019317638,
0.029577734,
0.017437046,
0.014609763,
0.011590583,
0.0072728987,
-0.012556464,
0.012319792,
-0.0106950635,
-0.012646017,
-0.014021279,
-0.00026425824,
-0.0043336754,
0.0060671456,
0.04006811,
0.0018038325,
0.0014927993,
0.007791021,
0.003844338,
0.0068635186,
0.014622556,
-0.02678883,
-0.03098498,
-0.02250313,
-0.024486065,
-0.019663053,
-0.009850716,
-0.011366703,
-0.03605106,
0.026916761,
-0.012409343,
-0.010688666,
0.0061694905,
-0.020379469,
-0.0037100099,
0.02829842,
0.007931746,
0.012857104,
-0.026737658,
0.019023396,
0.026085207,
0.011737704,
-0.032110777,
-0.007995711,
-0.007349658,
-0.008961593,
0.04191032,
0.025304826,
-0.00007510971,
-0.0165927,
0.008884834,
0.009543681,
-0.002675365,
-0.032315467,
0.012281412,
0.019624673,
0.0069338805,
-0.02319396,
-0.0074200197,
-0.011750497,
0.00721533,
-0.012473309,
0.010151355,
-0.008098057,
-0.011808066,
-0.021147057,
0.008405091,
-0.0066396384,
0.0064861206,
-0.016221698,
-0.008008504,
-0.02226006,
-0.037867688,
-0.03118967,
-0.013547933,
0.021658782,
0.023808029,
-0.005181221,
0.01439228,
0.020494606,
0.006406164,
-0.004899772,
0.004752651,
-0.01131553,
0.03922376,
-0.0090383515,
0.0101065785,
0.022938097,
0.0015223834,
0.011712118,
-0.034771748,
-0.0052867644,
0.0037739757,
-0.030677944,
-0.005465868,
0.05434525,
0.00717695,
-0.015428524,
0.021863472,
-0.02263106,
-0.005018108,
-0.0292707,
-0.023232339,
0.017270736,
-0.025048964,
0.01373983,
0.0060991286,
-0.006716397,
0.008705731,
0.012837914,
-0.0040650195,
-0.006569276,
0.022119336,
-0.023385856,
-0.010349648,
-0.007918952,
0.031547878,
-0.004714271,
-0.018972224,
-0.006172689,
-0.015275006,
-0.008449867,
-0.014686522,
-0.028119316,
-0.0062366547,
0.010746236,
0.008264367,
-0.0091343,
-0.004292098,
0.024895446,
0.028938077,
0.0036524408,
0.012358171,
-0.023027647,
0.024716342,
-0.005002117,
-0.024166238,
0.010573529,
-0.006837932,
-0.0065372935,
0.020852815,
0.014098038,
0.00031722983,
-0.0017158797,
-0.030857049,
-0.00721533,
0.010567131,
-0.023232339,
0.0012097511,
-0.0099402685,
0.017027667,
-0.00026185953,
0.015390145,
0.019752605,
-0.0078869695,
-0.018370945,
0.02919394,
0.030396495,
0.015070316,
-0.014904005,
-0.0062366547,
0.0034701386,
-0.02425579,
-0.035360232,
0.00555542,
-0.025010584,
0.022400783,
0.0055394284,
-0.016848562,
-0.026456209,
0.0015055924,
-0.039889004,
-0.0036684324,
0.008820868,
-0.0041097957,
0.0072473125,
0.014673729,
-0.021351747,
0.034950852,
-0.017513806,
-0.0012057532,
-0.02026433,
-0.021313367,
-0.0031311205,
-0.006278232,
-0.00028444742,
0.00011233974,
-0.040554248,
-0.014609763,
0.054447595,
-0.005792093,
-0.015019144,
0.03571844,
-0.028196076,
0.0069530704,
-0.017117219,
0.029219527,
-0.043906048,
0.019087361,
0.029731251,
-0.0057409205,
-0.0068315356,
-0.008667351,
-0.008699333,
-0.006239853,
-0.0030319737,
0.0024258988,
-0.0013072988,
-0.0054466785,
-0.009959457,
-0.04904889,
-0.0027681151,
-0.010215321,
0.032161947,
-0.005673757,
-0.013202518,
0.0055874027,
-0.0012681198,
-0.0054594716,
-0.023667306,
0.014904005,
0.01961188,
0.011405082,
0.005804886,
0.0061886804,
-0.0122238435,
0.01851167,
-0.014136417,
-0.02071209,
-0.006690811,
-0.017539391,
-0.0034317593,
-0.018780326,
0.0096268365,
0.02837518,
-0.018818706,
0.003070353,
-0.0048294095,
-0.02417903,
-0.030652357,
0.0018805913,
-0.0017238753,
-0.00402664,
-0.0057761017,
-0.0005652968,
-0.011744101,
-0.008852852,
0.00010404419,
-0.014545797,
-0.026149174,
0.013240898,
0.17900158,
-0.026891176,
0.016528733,
-0.0050756773,
0.007029829,
0.022771785,
0.010727046,
-0.015991421,
-0.007650296,
0.0015863491,
0.044545706,
-0.00086993334,
-0.010343252,
0.009729181,
0.0054722647,
-0.039812244,
-0.03551375,
0.0026817615,
-0.024038306,
-0.008712127,
-0.012441327,
0.0100234235,
0.0075927274,
0.0025106533,
0.038763206,
0.027889041,
-0.02719821,
0.008334729,
0.034618232,
-0.0024099073,
-0.037125684,
0.013624691,
-0.009812336,
-0.0073688473,
-0.0049541425,
-0.0028832534,
0.010125768,
0.0037164064,
0.016938115,
0.010592718,
-0.016861355,
-0.0031535085,
-0.0060863355,
-0.011673738,
0.017744083,
0.03559051,
-0.010503166,
0.0122238435,
-0.01687415,
0.0018550049,
-0.0274029,
-0.015134282,
0.05209366,
0.024857067,
0.018447705,
-0.0015383748,
0.035871956,
0.02226006,
0.0021908248,
0.0067611733,
0.0026113992,
0.016080974,
-0.043036114,
0.029296285,
0.00091470935,
0.027735522,
-0.022055369,
-0.0057249293,
-0.007362451,
0.017117219,
0.0029744045,
0.0021236609,
-0.018460497,
-0.011865635,
-0.00853942,
-0.011142823,
0.031982843,
0.0034125694,
-0.012051136,
0.012275016,
0.021901852,
0.018396532,
-0.031522293,
0.027735522,
0.009006369,
-0.020622538,
0.023680098,
0.0010394425,
-0.044315428,
0.0028656628,
-0.004151373,
0.00085634063,
-0.0075543476,
-0.022477543,
0.018844292,
-0.0065181036,
0.014942385,
-0.0035277077,
-0.0052931607,
-0.019458363,
-0.021466885,
0.07906159,
0.017091632,
0.009044749,
-0.013893347,
0.010292079,
0.005190816,
-0.013918933,
0.0041993475,
0.0065372935,
0.017833633,
-0.035948716,
0.0006752378,
-0.004112994,
0.0010890159,
0.025739793,
-0.0103176655,
-0.021709954,
0.01961188,
-0.01683577,
-0.0067291902,
-0.022490336,
-0.018153463,
0.026161967,
-0.0274029,
0.019560708,
-0.005501049,
0.02544555,
0.007938142,
-0.024780307,
0.0068763117,
-0.005174824,
0.016042594,
0.026430622,
0.01672063,
-0.016004216,
-0.019957295,
-0.025778173,
-0.015722767,
0.028042559,
-0.019522328,
-0.016221698,
0.015159869,
-0.009997837,
0.009665215,
-0.0031726982,
0.014993558,
0.016950907,
-0.011884825,
-0.027633177,
-0.0040586228,
-0.022810165,
-0.011309134,
-0.029935943,
0.034976438,
-0.02071209,
-0.006217465,
-0.017705703,
0.002046902,
0.002134855,
-0.016029801,
0.017257944,
0.017795255,
-0.00413858,
-0.012869896,
0.0020628935,
-0.15812318,
0.00939656,
0.02250313,
-0.018601222,
0.010592718,
0.008168419,
-0.0089551965,
-0.0054019024,
0.004743056,
0.0096268365,
0.053117108,
-0.01377821,
-0.042473216,
0.001045839,
0.011162013,
-0.0071449676,
-0.009095921,
0.050072342,
0.031982843,
0.015901871,
0.044673637,
-0.026123587,
-0.025419965,
-0.0022739803,
-0.0041897525,
0.009319801,
0.010272889,
-0.007823003,
0.0022068163,
-0.009281421,
-0.01133472,
0.006281431,
0.03344126,
0.01113003,
0.002891249,
0.004835806,
0.009607647,
-0.010592718,
0.0051460396,
0.037560653,
0.036639545,
-0.0043016924,
0.019356018,
0.018447705,
-0.02727497,
0.035488166,
-0.013445588,
-0.0075287614,
0.034464713,
-0.026558554,
0.0034093712,
-0.0326225,
0.0017398667,
0.009415749,
0.020417849,
0.018409325,
0.0059424127,
0.018447705,
-0.003115129,
0.0027409298,
-0.008200401,
-0.023181166,
0.019509535,
-0.0135863125,
0.016004216,
-0.012729172,
-0.009511698,
0.027454074,
0.009345387,
0.008692937,
-0.030882634,
-0.01306819,
0.0064861206,
-0.008782489,
0.0060447576,
-0.0058496622,
-0.0074200197,
0.022541508,
0.020289917,
0.0071449676,
-0.015223834,
0.003889114,
-0.017577771,
0.00049533433,
-0.032801606,
0.002764917,
-0.0048102196,
0.035948716,
-0.030959394,
0.0016439182,
0.02373127,
-0.029449804,
-0.017296322,
0.0020293114,
0.014980764,
0.04267791,
-0.009498904,
0.005094867,
0.0026561753,
0.0059232228,
0.03200843,
-0.02768435,
-0.0107782185,
-0.0011265957,
0.0005529034,
-0.007189743,
-0.037279204,
-0.014686522,
0.044059567,
0.0038027603,
0.016234491,
0.00070722064,
0.008232384,
0.013420002,
-0.023961548,
0.021709954,
-0.017219564,
-0.003956278,
0.021147057,
-0.009204662,
0.0605883,
0.00013802596,
-0.001157779,
0.029680079,
-0.011417875,
-0.025368793,
-0.12240474,
-0.026328277,
0.016605493,
0.005187617,
-0.02707028,
0.020852815,
-0.0031023358,
0.024191823,
-0.015095903,
-0.0027137443,
-0.026584141,
0.010445597,
-0.0022595879,
-0.016324043,
0.0033933797,
0.00032022822,
-0.008705731,
-0.0034541471,
-0.013228104,
0.0344903,
-0.005082074,
-0.023871996,
0.0061566974,
-0.0149679715,
0.0033230176,
0.015850699,
-0.0292707,
0.016746217,
0.019292051,
0.016605493,
0.008289954,
0.0025218474,
0.016234491,
0.013599105,
-0.0062238616,
-0.0022308035,
-0.0044584083,
-0.034746163,
0.029168354,
-0.012780345,
-0.010605511,
-0.008648161,
-0.008692937,
-0.0043208823,
0.0049413494,
-0.011034082,
-0.03367154,
-0.019458363,
0.03886555,
-0.024025513,
-0.030729117,
-0.02315558,
-0.027172625,
-0.01830698,
-0.0024274979,
0.0112387715,
0.0016727027,
0.014098038,
-0.0018118281,
0.00891042,
-0.0008299548,
-0.006307017,
-0.017884806,
0.0013608701,
0.025637448,
-0.0005505047,
-0.0050660823,
-0.012326188,
0.023526581,
-0.03901907,
0.0021732342,
-0.007784624,
-0.021044713,
-0.0028192878,
0.010483976,
0.011692928,
-0.021006333,
-0.0081172455,
-0.001601541,
-0.018038325,
-0.03379947,
-0.007240916,
0.009543681,
-0.002035708,
0.053321797,
0.015582042,
0.0016519139,
-0.02307882,
-0.0021124668,
-0.013611899,
-0.029654494,
0.031726982,
0.007854987,
-0.005734524,
-0.007004243,
-0.0042441236,
-0.016400803,
-0.0016063383,
0.021953024,
0.017398667,
-0.021658782,
-0.029654494,
-0.051223725,
0.011072461,
-0.015658801,
0.0027361324,
-0.0078869695,
-0.015965836,
-0.0007320074,
-0.023040442,
0.020392261,
0.023603339,
-0.0004677491,
0.0018470093,
-0.00229317,
0.0039051054,
-0.018741947,
0.0005457073,
0.008795282,
0.002742529,
0.0060127745,
-0.0004653504,
-0.0008507437,
-0.0010274489,
-0.005203609,
0.010272889,
-0.012511688,
0.00080716703,
0.014891213,
0.027326142,
-0.020289917,
-0.007343261,
0.0011050072,
-0.039761074,
-0.010093786,
0.009262232,
-0.03037091,
-0.021837886,
-0.013420002,
0.0352323,
0.0018534058,
0.028528698,
0.007029829,
-0.03986342,
0.025189688,
-0.01782084,
-0.0028192878,
-0.013304863,
-0.031957258,
0.028656628,
0.005827274,
-0.0032190734,
0.04004252,
0.021223815,
0.0072345193,
-0.039607555,
-0.009070335,
0.009837923,
-0.0075543476,
-0.024204617,
-0.005974395,
-0.020353882,
0.005181221,
0.018844292,
0.015108695,
0.013093776,
-0.023923168,
-0.011449859,
-0.014225969,
-0.0010018626,
0.007036226,
-0.0053795143,
-0.010144958,
0.017795255,
-0.0073816404,
-0.00014642146,
0.024652377,
0.005788895,
-0.015876284,
0.016324043,
-0.029168354,
0.022541508,
0.021889059,
-0.01855005,
-0.014379486,
0.020980746,
0.04759047,
0.0032478578,
-0.024268582,
0.02699352,
0.010138562,
-0.012793138,
-0.004877384,
0.009402956,
0.0128315175,
0.017488219,
0.018741947,
0.0072473125,
-0.005788895,
0.021582024,
-0.004752651,
0.051505174,
0.005318747,
0.0033933797,
0.009671612,
0.008264367,
-0.007477589,
0.01047758,
-0.02576538,
-0.024370927,
-0.0123901535,
-0.012748362,
0.0034669403,
0.005939214,
-0.024793101,
0.005382713,
-0.032161947,
0.016669458,
-0.015466903,
0.015889077,
-0.0072792955,
0.00096268364,
0.006914691,
0.0057409205,
-0.006073542,
-0.0036300528,
-0.00058528606,
0.0050660823,
0.042575564,
-0.005149238,
0.005913628,
0.018818706,
-0.010343252,
0.0025394377,
-0.045850605,
-0.0062046717,
-0.019100154,
-0.0022659844,
0.026405036,
0.02067371,
-0.023053234,
0.08474174,
0.0011090052,
-0.026021242,
0.0008211595,
-0.000497733,
0.0062014735,
0.018946636,
0.018447705,
-0.0054274886,
-0.015479697,
0.027326142,
-0.0016295259,
0.020865608,
-0.023091614,
-0.025663035,
-0.0003514115,
0.0051428415,
-0.0034253625,
-0.0032590518,
-0.00393389,
0.020238744,
0.0058528604,
0.0035373026,
0.0015391744,
-0.03275043,
-0.0015071916,
0.027965799,
-0.018575637,
0.00015051926,
-0.03295512,
-0.011731307,
-0.0027968998,
-0.053219453,
-0.012492499,
0.0073816404,
-0.0144434525,
-0.016848562,
-0.03420885,
0.0300127,
0.02552231,
-0.020648124,
0.043650188,
-0.014059658,
-0.008021297,
0.007324071,
-0.0061566974,
-0.018498877,
0.0014136417,
-0.029168354
] |
Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that function as intracellular sensors for sterols and bile acids, respectively. In response to their ligands, these receptors induce transcriptional responses that maintain a balanced, finely tuned regulation of cholesterol and bile acid metabolism. LXRs also permit the efficient storage of carbohydrate- and fat-derived energy, whereas FXR activation results in an overall decrease in triglyceride levels and modulation of glucose metabolism. The elegant, dual interplay between these two receptor systems suggests that they coevolved to constitute a highly sensitive and efficient system for the maintenance | [
-0.0042620753,
0.007377049,
-0.005363029,
-0.026014151,
-0.03715554,
0.0061805034,
-0.014925504,
0.0005249308,
-0.004321408,
-0.010844723,
0.024722014,
-0.0030391596,
-0.017087856,
0.012730189,
-0.011306201,
0.004298334,
0.029666416,
-0.003325935,
0.000368564,
0.009684437,
-0.009044961,
0.010442578,
-0.015057354,
-0.0141344,
-0.0058838394,
-0.0055509163,
0.027266733,
-0.03794664,
-0.019711686,
-0.034834966,
0.011853382,
-0.0031825472,
-0.021148859,
0.007884675,
0.029323604,
0.0019382059,
-0.000119901764,
-0.020740122,
0.00935481,
-0.014529952,
0.025341712,
0.013712477,
0.0025644968,
0.031011295,
0.0041203354,
-0.0020667603,
0.015255131,
-0.024537424,
-0.026805256,
0.012769744,
0.01338285,
0.00067738316,
-0.005943172,
-0.028875312,
-0.018670065,
-0.005903617,
-0.0028809386,
0.0066650547,
-0.0019217245,
-0.027635915,
-0.030694852,
-0.014938689,
-0.02125434,
0.005831099,
0.009302069,
0.027767766,
0.0067342767,
0.036179844,
-0.016731858,
0.020357754,
0.018234957,
0.013191666,
-0.00593658,
0.021017008,
0.018459104,
-0.010172284,
-0.023034325,
-0.015096909,
-0.0018525029,
0.009051553,
0.02840065,
0.002823254,
-0.008761481,
0.034729484,
0.015795719,
-0.0025364787,
0.018920582,
0.02138619,
0.00977014,
-0.010422801,
0.010284358,
0.01758889,
0.04456555,
0.022678327,
-0.016731858,
0.006836461,
0.018076736,
0.0072847535,
-0.021702632,
-0.022717882,
-0.001534413,
0.008359337,
-0.020898342,
-0.008807629,
-0.029745527,
0.00019705505,
-0.028611612,
-0.0006234068,
0.01423988,
0.006915571,
-0.013204852,
0.028690722,
0.017219707,
-0.024366017,
0.036759987,
-0.019171098,
0.01849866,
-0.012301674,
-0.012268712,
-0.0048685884,
0.012624708,
0.019672131,
-0.0075880103,
-0.003350657,
0.010198655,
-0.005583879,
-0.009394365,
-0.0074825296,
-0.022902474,
0.0120577505,
0.005831099,
-0.004097262,
-0.00072353095,
0.009934953,
-0.017496593,
0.010060212,
-0.0025167011,
0.007344086,
0.007291346,
-0.010027248,
0.015558387,
0.03014108,
-0.032435283,
0.012301674,
-0.005221289,
0.023812244,
0.018643694,
0.01499143,
-0.0048916624,
-0.005778359,
0.004024744,
-0.010719465,
0.04042544,
-0.013580626,
-0.0038863006,
0.029692786,
0.016389048,
0.03174966,
0.006167318,
-0.015822088,
-0.0009930009,
-0.02481431,
0.00017573232,
0.017417483,
0.019975387,
0.022599217,
0.01576935,
0.02052916,
-0.0017124115,
0.011985232,
0.019012876,
0.012789521,
-0.021373006,
0.029745527,
-0.011714938,
0.027398584,
-0.0091636265,
0.0013193315,
-0.0038994856,
-0.014833208,
-0.015782533,
0.00841867,
0.045514874,
-0.023851799,
-0.009994286,
0.008227486,
0.01710104,
-0.04290423,
0.00166956,
-0.021017008,
0.003314398,
0.022757437,
-0.018234957,
-0.032698985,
-0.6387905,
-0.009269107,
0.009526216,
-0.005587175,
0.013580626,
0.03209247,
0.0032468245,
0.0008726871,
0.003830264,
0.005969542,
-0.012776337,
-0.000785748,
0.027662285,
-0.037287388,
-0.017562518,
-0.027134882,
-0.025710894,
-0.0067705354,
0.028321538,
-0.014477211,
0.0036555617,
0.003327583,
-0.023113435,
0.018300883,
0.00711994,
0.017470224,
0.012987298,
-0.018538214,
0.018854655,
0.016244011,
-0.017575704,
0.037287388,
0.0111084245,
0.015162835,
0.044750143,
0.0045158877,
-0.00640465,
0.03385927,
0.038553156,
0.05289852,
-0.021887222,
-0.005306992,
0.029692786,
0.0019546873,
-0.023548542,
0.016389048,
0.02055553,
0.03802575,
0.006150837,
0.0032633059,
-0.005046587,
0.013033446,
0.003424823,
-0.000147302,
0.010719465,
0.022177294,
0.018169032,
-0.016059421,
-0.008194524,
0.03048389,
-0.010666725,
0.009480068,
-0.025183491,
-0.0058376915,
-0.016468158,
0.017839406,
-0.01603305,
0.010864501,
0.008715334,
-0.002491979,
0.024366017,
0.028769832,
-0.006302465,
0.019817166,
-0.0016827451,
0.0143189905,
0.026475629,
0.02045005,
0.004974069,
0.043352522,
0.0009995934,
0.00078863226,
-0.017127411,
0.006460686,
0.017562518,
-0.002932031,
0.014595877,
-0.0038137827,
0.011820419,
-0.007891267,
0.011780864,
-0.012868633,
-0.019026062,
-0.038711376,
-0.0185514,
0.03174966,
-0.023917723,
0.013606996,
0.024511052,
-0.026185557,
-0.012176416,
-0.013086186,
-0.0020354458,
-0.0013374609,
0.013672922,
0.0031644178,
-0.02660748,
0.00068191555,
0.02408913,
-0.03731376,
0.0121500455,
-0.0121500455,
-0.0068562385,
0.012413748,
-0.015571573,
-0.019764425,
0.010937019,
0.0054718056,
-0.02037094,
-0.039027818,
0.05136905,
-0.014912318,
0.01021184,
-0.007996747,
0.011299608,
0.025157122,
-0.0011330923,
-0.01584846,
-0.0046213684,
-0.009157034,
0.009664659,
0.018472288,
0.013448776,
-0.016336307,
0.005221289,
0.016402232,
0.032356173,
-0.0116951605,
0.0024738496,
-0.038711376,
-0.036549024,
-0.008293412,
-0.0008644464,
-0.025434008,
-0.009453698,
-0.0014965059,
0.006444205,
0.023601282,
0.00974377,
0.0008570298,
-0.019711686,
-0.0021590558,
-0.035204146,
0.014068474,
0.008194524,
-0.0031776028,
-0.005864062,
0.0022810178,
-0.006948534,
0.007864896,
-0.005115809,
0.01252582,
-0.0071133473,
0.0058146175,
-0.0146354325,
0.0019332615,
0.03024656,
0.012657671,
0.0034577856,
-0.03393838,
0.00888674,
-0.008306596,
-0.021913594,
0.0060980967,
0.0046675163,
0.007673713,
-0.00166956,
-0.013817958,
0.025447194,
-0.01779985,
0.015822088,
0.009585549,
-0.032857206,
-0.0064112423,
0.0046213684,
-0.0019810575,
0.025513118,
0.01151057,
0.0024161648,
0.009776732,
-0.020753307,
0.013580626,
-0.00554762,
0.009664659,
0.011998418,
-0.025605414,
0.011279831,
-0.00017109694,
-0.0026914033,
0.00604206,
0.021729002,
-0.02494616,
0.030088339,
-0.022203665,
0.00640465,
-0.006714499,
0.011794048,
-0.0061178743,
0.0015780885,
-0.010712872,
-0.00080346543,
-0.0075220848,
-0.00010589263,
-0.029587306,
0.004591702,
0.0031512326,
0.013165296,
0.004186261,
0.005623434,
-0.044671033,
-0.0034676744,
-0.007805564,
0.039265152,
0.014253065,
0.010218432,
0.010027248,
-0.012334636,
0.0054553244,
-0.02135982,
-0.0057981363,
-0.009559179,
-0.018670065,
0.0019002988,
0.010646948,
-0.006223355,
0.008049488,
0.005148771,
-0.010673317,
0.014543137,
-0.0035434887,
0.032989055,
-0.004034633,
0.023891354,
0.012235749,
-0.008306596,
-0.02219048,
0.023627652,
0.019513909,
-0.006668351,
-0.0035303035,
-0.0035467849,
0.018274512,
-0.021399375,
-0.0061310595,
0.006579352,
0.0032731947,
0.03412297,
0.0055443235,
0.024234166,
0.00756164,
0.022058628,
0.01798444,
-0.018590955,
-0.0011503977,
0.0062035774,
0.030035598,
-0.02151804,
-0.008609854,
-0.0072122356,
-0.011286424,
-0.02312662,
-0.0014948577,
0.0004948523,
-0.02491979,
0.023034325,
0.016507713,
0.031406846,
-0.0044005183,
0.024708828,
0.0035797476,
0.007185865,
-0.033621937,
0.038315825,
0.011411682,
-0.011642421,
-0.029218124,
-0.051210828,
-0.022309145,
0.025407638,
0.015030985,
0.027477695,
-0.019790797,
0.010719465,
-0.004430185,
-0.012097306,
0.004782886,
0.031143146,
-0.040135365,
0.020014942,
0.0005793192,
0.019118357,
-0.0048554037,
0.00932844,
-0.012598339,
0.027530435,
-0.0054948796,
-0.006477168,
-0.004627961,
0.028611612,
-0.019790797,
0.009816288,
-0.01023821,
-0.007304531,
-0.029402714,
0.005428954,
-0.006065134,
-0.026356963,
0.008095635,
0.007759416,
-0.005929987,
-0.011780864,
-0.058278028,
-0.010561245,
0.006342021,
0.027741395,
0.006628796,
-0.004565332,
0.012262119,
-0.0051685493,
-0.006206874,
-0.0101129515,
-0.024471497,
0.0021557596,
0.011583088,
0.0075880103,
0.0018211884,
-0.020898342,
0.00016934579,
-0.0010597503,
0.0016481342,
-0.0006897442,
-0.038394935,
-0.002012372,
-0.014450842,
-0.0030177338,
-0.00940755,
0.030800333,
0.027899617,
0.011932492,
-0.014068474,
0.0021409264,
0.025565859,
-0.011945677,
-0.02406276,
0.017813034,
-0.0023057398,
-0.005086142,
0.003044104,
-0.006602426,
-0.008721926,
0.00049196807,
-0.016125346,
0.0038764118,
-0.0067342767,
0.0196985,
0.008451632,
0.026396519,
-0.0004800191,
0.007944007,
-0.013593812,
-0.017786665,
0.012558783,
0.009737177,
-0.0053959917,
0.004123632,
-0.0048685884,
0.002813365,
-0.006032171,
-0.016560454,
-0.023218915,
0.015663868,
-0.011035907,
0.00024021557,
-0.023640838,
0.006520019,
-0.008128598,
0.03343735,
-0.005501472,
0.015914384,
-0.0017700961,
-0.003596229,
-0.036601767,
-0.020845601,
0.022731068,
0.004505999,
-0.029719157,
-0.004492814,
0.0072451984,
0.001301202,
-0.0021227968,
-0.0039357445,
-0.023535358,
0.022388255,
0.025420822,
-0.030615741,
-0.004894959,
-0.0048554037,
-0.02564497,
-0.00017037588,
-0.018274512,
0.024840679,
-0.02998286,
0.0028281985,
0.019843537,
0.004568628,
-0.009836066,
0.021544412,
-0.02128071,
-0.007502307,
0.0059827273,
0.019500725,
0.015650682,
0.013250999,
-0.016850526,
-0.014609062,
0.004466444,
-0.009862435,
-0.02060827,
-0.0018689842,
-0.014503581,
0.020014942,
0.014569507,
-0.027952356,
-0.0075814174,
0.010396431,
0.011859974,
-0.009282292,
-0.004367556,
-0.0048092557,
0.02055553,
-0.0001533795,
0.034914076,
0.0058871354,
-0.019935831,
-0.004835626,
-0.020186348,
0.026159188,
0.0097503625,
-0.023588097,
0.00792423,
0.00021343339,
0.004983958,
-0.004604887,
0.013079594,
0.0094339205,
0.014477211,
-0.008629631,
-0.02850613,
-0.030932184,
0.015901199,
-0.024075946,
-0.004159891,
-0.013501516,
-0.008735112,
-0.0029073087,
0.018525029,
0.007390234,
-0.023706764,
0.020885156,
-0.029560937,
0.00075772975,
0.009585549,
-0.013686107,
0.023403507,
0.011827012,
-0.021478485,
-0.048942994,
-0.011912715,
-0.011484199,
-0.0431943,
0.0014536544,
-0.008359337,
0.022586033,
0.015004614,
0.023574913,
0.0053828065,
0.006345317,
-0.007264976,
0.000020601678,
0.00097157515,
-0.006295873,
0.014398101,
-0.033490088,
0.0032221025,
0.0026205336,
-0.011747901,
0.014609062,
-0.018485473,
0.015888015,
0.017364742,
-0.01195227,
-0.0022810178,
-0.007390234,
-0.00990199,
-0.022335516,
0.0011058981,
0.004146706,
-0.003803894,
-0.030563002,
-0.010350283,
0.017391114,
-0.00245572,
0.02138619,
-0.008273634,
0.03407023,
-0.038632266,
0.021649892,
0.0026353667,
-0.0056926557,
0.0072122356,
-0.019118357,
0.008965851,
0.0060354676,
-0.009480068,
-0.010976574,
0.021373006,
0.021069748,
-0.012960928,
0.023495803,
-0.019553464,
-0.004176372,
0.001854151,
0.0027556806,
-0.0050004395,
-0.008524151,
-0.003744561,
-0.0019563353,
-0.03947611,
-0.025328528,
0.02855887,
-0.012281897,
0.02497253,
-0.008504373,
-0.019817166,
0.028295169,
-0.0074297893,
0.024194611,
-0.039977144,
0.032488022,
0.017865775,
0.015716609,
-0.029613676,
-0.012710411,
0.010963389,
-0.01522876,
0.042455938,
0.013073001,
-0.0023518875,
-0.009308662,
-0.01249945,
0.011688568,
-0.020977452,
-0.03016745,
-0.010192062,
-0.014833208,
-0.0018244847,
-0.011240276,
-0.013336702,
-0.018670065,
0.002272777,
-0.02585593,
-0.0001742902,
-0.0065595745,
0.016534083,
-0.01889421,
0.034703113,
-0.0076407506,
-0.0029616973,
-0.010811761,
-0.005178438,
0.00886037,
-0.030589372,
-0.008234079,
0.0023733133,
0.00535314,
0.03596888,
-0.006539797,
0.01158968,
0.013606996,
0.0188151,
0.0058113215,
-0.041506615,
-0.02325847,
0.037287388,
-0.0051520676,
0.00083024765,
0.031090405,
0.007884675,
0.005953061,
-0.015439722,
0.0023518875,
-0.012901595,
-0.020107238,
0.012565375,
0.017654814,
-0.0030704741,
-0.04082099,
0.019606205,
-0.03174966,
-0.0027935875,
-0.035045926,
-0.004641146,
0.026396519,
-0.036786355,
-0.009091108,
0.004288445,
0.0073836413,
0.022203665,
0.0035204147,
0.009783325,
-0.014055289,
0.029323604,
-0.040372696,
0.027029403,
-0.0024573682,
0.01512328,
-0.030984923,
0.010798575,
-0.021874039,
-0.027846877,
0.01798444,
-0.022309145,
-0.031274997,
-0.037893903,
-0.00402804,
-0.003325935,
0.03198699,
0.0011611106,
0.0005616018,
-0.012354414,
0.0144112855,
-0.0036819319,
-0.002811717,
0.014345361,
-0.01600668,
0.023574913,
0.009928361,
-0.010225025,
0.005115809,
0.00048537555,
-0.0021310376,
0.012598339,
0.02060827,
0.0014305805,
-0.01114798,
0.030879444,
-0.024590163,
-0.003668747,
-0.012901595,
-0.012169823,
-0.027504064,
0.017087856,
0.0066881287,
-0.023007954,
-0.010824946,
-0.013237814,
0.009216366,
0.010053619,
-0.019843537,
-0.0009476772,
-0.017443852,
-0.005646508,
-0.025064826,
0.0066222036,
-0.031116774,
0.026383333,
0.0060585416,
-0.029191755,
0.0020288532,
-0.00035826318,
-0.006150837,
-0.016547268,
-0.0072517907,
0.01980398,
-0.0249989,
0.009605327,
0.007232013,
0.02414187,
-0.0011264997,
0.0078121563,
-0.011438052,
-0.033463717,
0.019052433,
-0.013672922,
0.04119017,
0.010442578,
-0.033542827,
-0.021979518,
0.02695029,
-0.024880234,
-0.012690634,
0.020094052,
-0.040267218,
0.012954336,
-0.0059596533,
0.012248934,
0.024471497,
0.014055289,
0.014820023,
-0.023469431,
0.017219707,
0.010442578,
0.0002676158,
-0.011649013,
0.0006885081,
0.002554608,
0.015004614,
0.009717399,
-0.008451632,
-0.0061178743,
0.026818441,
0.0019991868,
0.020159978,
-0.011675383,
0.011246868,
-0.013883883,
0.009064739,
-0.0282688,
0.0012979057,
-0.009124071,
-0.012196193,
0.011180943,
0.003510526,
0.015004614,
-0.008820814,
0.009137256,
-0.019790797,
-0.016336307,
0.03786753,
-0.021900408,
-0.0011083703,
-0.032857206,
0.023627652,
-0.02063464,
-0.013541071,
-0.021491671,
-0.0020041312,
-0.010152507,
-0.0008669186,
-0.000050293846,
0.0015607831,
-0.010930426,
0.005115809,
0.014754098,
-0.0030622336,
-0.017615259,
-0.003573155,
-0.024590163,
-0.008405484,
0.017668,
0.17530875,
-0.026198743,
0.007897859,
0.015558387,
0.0036291915,
0.0028150133,
0.0040840767,
-0.00031087932,
-0.023680393,
0.019869907,
0.01948754,
0.012334636,
-0.02401002,
0.0019068914,
0.0042455937,
0.0065233153,
-0.031723287,
0.0043148156,
0.0029435677,
-0.005926691,
0.0056300266,
-0.004618072,
-0.0066716475,
-0.027161252,
0.061600666,
-0.0030029006,
-0.018617325,
0.010257987,
0.014661802,
0.0043411856,
-0.0032369357,
-0.0024639608,
-0.0011503977,
0.0072056428,
0.016217642,
-0.0050762533,
-0.016665934,
0.012710411,
0.0032731947,
-0.008728519,
0.004772997,
0.012136861,
-0.029560937,
-0.017298818,
0.0028397352,
0.014529952,
0.008220893,
-0.020133609,
-0.021043379,
0.019091988,
-0.04111106,
0.020344568,
0.0058739507,
0.028954422,
-0.013330109,
-0.01421351,
0.012459895,
0.02141256,
0.016586823,
0.018155847,
-0.005020217,
0.011596273,
-0.019711686,
0.029270865,
-0.011115017,
0.047466267,
-0.016665934,
-0.0074297893,
0.025710894,
-0.012644486,
-0.000736716,
0.025750449,
-0.008280227,
-0.003278139,
0.0012855447,
0.003388564,
0.004225816,
0.015162835,
0.014820023,
0.015835274,
0.0031413438,
-0.011312794,
-0.03802575,
0.024590163,
-0.0070276447,
-0.023588097,
0.011128202,
0.0020601677,
-0.030642113,
0.009460291,
0.012875224,
0.0016975782,
-0.019237023,
-0.009361402,
-0.0045224805,
-0.023812244,
0.004799367,
0.0021574078,
-0.017813034,
-0.0056794705,
-0.034914076,
0.07114666,
-0.002295851,
0.0285325,
-0.02291566,
0.0037643386,
-0.011807234,
0.014147584,
-0.011576495,
0.01156331,
0.023944095,
-0.023205731,
0.0016778007,
-0.008893332,
-0.017839406,
0.0067705354,
0.034993187,
-0.022731068,
0.014464026,
-0.009077923,
-0.011787456,
0.0021672966,
0.005491583,
0.005007032,
-0.003817079,
-0.012196193,
-0.032646243,
-0.032567132,
0.0006444205,
-0.031485956,
-0.00886037,
-0.017562518,
0.001681097,
-0.0005142179,
-0.0023980353,
-0.019474354,
0.0323298,
-0.004334593,
-0.008807629,
0.03006197,
-0.017549334,
0.019289764,
0.025790004,
0.011583088,
0.021847667,
-0.024603348,
0.01592757,
0.005732211,
-0.01145783,
0.039766185,
-0.010027248,
-0.00932844,
0.00005168446,
0.004898255,
0.036707245,
-0.017483408,
-0.010778798,
-0.04670153,
0.03565244,
0.0123676,
-0.026317408,
0.0019810575,
0.03525689,
-0.0315387,
-0.0039489297,
0.020990638,
-0.16571002,
0.011859974,
0.021794928,
-0.023298025,
0.013514701,
0.014173955,
0.01437173,
0.01114798,
-0.023588097,
0.010435986,
0.01603305,
0.0042851493,
-0.029666416,
-0.038104866,
-0.0010663428,
-0.01117435,
-0.011767679,
0.021583967,
-0.012295081,
0.013804773,
0.03567881,
-0.014424471,
0.0022744252,
-0.043879926,
0.024761569,
0.021162044,
-0.0022777217,
0.00032983287,
-0.015822088,
-0.0039258557,
-0.0064870566,
0.013527886,
0.028980793,
0.010686503,
0.024431942,
0.007225421,
-0.0016852173,
-0.016784599,
-0.00626291,
0.025631784,
-0.004311519,
0.031565066,
-0.016415417,
0.011728124,
-0.018722804,
0.012571968,
-0.014780468,
-0.013363073,
0.012598339,
0.0028759942,
-0.012492858,
-0.009216366,
0.014622247,
0.009335033,
0.04643783,
0.00849778,
-0.0022744252,
0.042271346,
-0.003817079,
-0.013712477,
-0.0077264532,
-0.014398101,
0.023469431,
-0.010495319,
0.01239397,
-0.0026749219,
-0.0100668045,
-0.020120423,
-0.031037664,
-0.0063683908,
-0.016982375,
-0.021610336,
0.008814222,
-0.0016440139,
0.04137476,
0.01065354,
-0.010726058,
-0.0016860414,
0.012459895,
-0.0009048257,
0.0019316133,
-0.0077264532,
-0.02505164,
-0.014701357,
-0.011405089,
0.0029880675,
0.018801916,
0.014345361,
0.0027326066,
-0.008201116,
0.034703113,
-0.028901683,
-0.00033148102,
-0.0069287564,
-0.005695952,
0.010950204,
0.0033292312,
-0.0048191445,
-0.0062991693,
0.026647035,
0.014806838,
-0.01702193,
0.0037940051,
-0.009130664,
0.015004614,
-0.0110161295,
-0.030035598,
0.009216366,
0.02850613,
-0.017562518,
0.002750736,
0.0040148553,
-0.012380784,
0.028875312,
-0.0011891288,
-0.01772074,
0.0036654505,
-0.006137652,
0.012796114,
-0.03393838,
0.05002417,
0.010231618,
-0.0015426537,
0.018089922,
0.0077791936,
-0.012954336,
-0.12330681,
-0.031090405,
-0.0040445216,
0.021887222,
-0.0069023864,
0.035151407,
0.000121446894,
-0.000056757624,
0.007152903,
0.026396519,
-0.020832418,
-0.0025216455,
-0.001620116,
-0.02325847,
0.0039060782,
0.006618907,
0.02310025,
-0.0146354325,
-0.00380719,
0.038447674,
0.0072451984,
-0.04097921,
-0.012644486,
0.0052740294,
0.0020107238,
0.0021030193,
-0.018841472,
0.00014019442,
0.0021425746,
0.0074363817,
0.0066947215,
-0.004957588,
0.007996747,
-0.017219707,
-0.0023749615,
-0.02847976,
0.01603305,
-0.01125346,
0.0076209726,
-0.01112161,
0.020410495,
-0.00036650387,
0.015268316,
-0.007390234,
0.0015319408,
-0.0004235705,
-0.020726936,
-0.0027836987,
0.0065496857,
0.00857689,
-0.044011775,
-0.038263086,
-0.03203973,
-0.03016745,
0.03755109,
-0.0070144595,
-0.0025991078,
0.03546785,
-0.023733133,
-0.0002997544,
0.025038455,
0.022849733,
-0.018525029,
0.019962203,
0.009493253,
-0.013752032,
0.00643102,
-0.02416824,
0.009011998,
-0.006272799,
-0.012585153,
0.029402714,
0.0014536544,
0.004037929,
-0.011649013,
0.03032567,
-0.018472288,
-0.0032352875,
-0.0034874522,
-0.03588977,
0.0028331429,
-0.025368083,
0.013989364,
-0.016362676,
0.0055904714,
0.017944885,
0.010304135,
-0.0038368565,
-0.008570299,
-0.01158968,
-0.023443062,
0.0247352,
0.015914384,
-0.015268316,
-0.015756164,
-0.0003498165,
0.011543532,
-0.0041796686,
0.016349493,
-0.0028463278,
-0.007772601,
-0.013936623,
-0.04978684,
0.005587175,
0.007337494,
-0.0008121182,
0.015940754,
-0.005511361,
0.018946951,
-0.020779677,
0.0034907483,
0.0010234914,
-0.029771898,
0.01514965,
0.010996352,
0.004258779,
-0.013501516,
-0.023007954,
0.030747592,
0.010989759,
0.012209378,
0.0446974,
0.006988089,
0.009730585,
0.016626379,
-0.0056893593,
-0.03567881,
0.0008463169,
-0.016784599,
0.01863051,
-0.021373006,
-0.011886344,
-0.013844328,
-0.026673404,
-0.019157913,
0.022783808,
-0.023601282,
-0.021808112,
-0.014450842,
0.013817958,
0.023851799,
0.012908188,
-0.010192062,
-0.0315387,
-0.0055904714,
-0.005903617,
-0.009499846,
-0.013765218,
-0.018604139,
0.004578517,
0.000798109,
0.00019695204,
0.019223837,
0.0138706975,
-0.0017486705,
-0.02037094,
-0.02128071,
-0.004235705,
-0.011985232,
-0.027293103,
-0.026159188,
-0.038078494,
0.010495319,
0.032672614,
0.0015484222,
-0.021373006,
0.0090251835,
-0.03372742,
-0.018801916,
-0.017931702,
0.030642113,
-0.04614776,
-0.04432822,
0.019197468,
-0.00015059827,
0.003830264,
0.008293412,
-0.0010630466,
-0.009381181,
-0.008590076,
-0.02489342,
0.011609457,
0.01980398,
-0.008484595,
-0.014674988,
0.023166176,
0.0000045677784,
0.0009460291,
-0.026053706,
-0.012585153,
0.018274512,
0.02845339,
-0.0013044983,
0.019263392,
0.006790313,
0.00045323692,
-0.005695952,
0.0075220848,
-0.011576495,
0.0034314154,
-0.01023821,
0.015940754,
0.0031215663,
0.008979036,
0.003988485,
-0.016349493,
0.006407946,
0.010416209,
-0.015677053,
-0.033252757,
-0.023588097,
-0.00601569,
-0.016481342,
0.012255526,
-0.0011817123,
-0.005709137,
-0.0042159273,
0.012176416,
-0.0026732737,
0.0097503625,
-0.00044788048,
-0.013409221,
0.038474046,
0.025473563,
-0.011622643,
0.00013494099,
0.009348217,
0.0020947787,
0.044961102,
-0.015888015,
0.017430669,
-0.0123676,
0.015268316,
-0.0036753393,
-0.030088339,
-0.01611216,
-0.0005195743,
0.008385707,
-0.001399266,
0.010350283,
-0.04050455,
0.086124904,
0.017615259,
-0.01980398,
0.004763108,
-0.002271129,
0.04970773,
-0.019197468,
0.017140597,
-0.022651957,
-0.009585549,
0.033094537,
-0.01675823,
0.00051462994,
-0.03562607,
-0.014609062,
0.023139805,
-0.0110425,
-0.0073506786,
0.0052608447,
-0.02652837,
-0.011840196,
-0.0101590995,
0.00062134664,
-0.010666725,
-0.03596888,
-0.013699292,
0.056484856,
0.017312001,
-0.00012196194,
-0.020001758,
-0.009915176,
0.019447984,
-0.015294686,
0.008781259,
0.014582692,
-0.0027589768,
-0.01338285,
0.0036423767,
0.013738847,
0.037129167,
0.0021195007,
0.029771898,
-0.0043148156,
-0.0497341,
0.014279435,
0.004822441,
-0.015492462,
0.013593812,
-0.036232583
] |
Kaposi's sarcoma-associated herpesvirus (KSHV), also termed human herpesvirus type 8, is consistently identified in Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease. Here we report four cases of KSHV-bearing solid lymphomas that occurred in AIDS patients (cases 1 to 3) and in a human immunodeficiency virus (HIV)-seronegative person (case 4). The patients presented extranodal masses in the abdomen (cases 1, 3, and 4) or skin (case | [
0.0012445017,
-0.0018319064,
0.021080198,
-0.040487785,
-0.013832221,
0.015783599,
0.0045266673,
-0.017097794,
-0.021690834,
0.0069625718,
0.015531381,
0.007785602,
-0.0024939813,
0.019473962,
-0.024186475,
0.014217187,
0.025925457,
-0.016434059,
0.016646454,
-0.019168643,
-0.030239731,
-0.0019314665,
-0.00020472052,
-0.0315141,
-0.024053728,
0.012119787,
0.027611343,
-0.028354725,
-0.005333104,
-0.027558245,
0.008522348,
-0.0015971104,
0.004593041,
0.008071008,
-0.009896277,
0.011774645,
0.015093315,
-0.008309952,
0.014575603,
0.0025288274,
0.0008479204,
0.0136331,
-0.004539942,
-0.009783442,
-0.0076727676,
0.004277767,
-0.000031786647,
-0.033425655,
-0.0147349,
0.034514178,
0.017907549,
0.0094383005,
-0.006982484,
0.016965047,
-0.009531223,
-0.001078568,
0.025328098,
-0.00034099346,
0.0017970604,
-0.045930408,
0.009717069,
-0.018066846,
-0.021412065,
0.018319065,
-0.0038264277,
0.013938419,
-0.015345535,
0.010845417,
0.013314508,
0.010148496,
0.040540885,
0.013699474,
-0.0357089,
0.011097636,
0.02335017,
-0.017549133,
-0.012962729,
0.01323486,
0.00051522366,
-0.0002644566,
0.0252219,
-0.033903543,
-0.012352093,
-0.0014660229,
0.019487236,
0.0019513785,
0.0058143116,
0.020336816,
0.011004713,
-0.008588721,
0.005416071,
0.013175124,
0.01021487,
0.013580002,
-0.030345928,
0.01638096,
0.021120023,
0.02819543,
0.009975925,
-0.04826675,
-0.015650852,
-0.003131166,
-0.025049329,
-0.016792476,
-0.014018066,
0.012053413,
0.0021787076,
0.008754654,
0.007705954,
-0.005273368,
-0.032841567,
0.038815178,
0.018451812,
-0.0336646,
0.02437232,
-0.0077325036,
0.011900755,
-0.009770167,
-0.014522504,
-0.0011192218,
0.0075201085,
0.016062368,
-0.0067037153,
-0.018040296,
0.034646925,
-0.010347616,
-0.01748276,
-0.023708586,
0.00024205557,
-0.011290119,
0.017164167,
0.016951771,
0.01510659,
-0.009909552,
0.00034700855,
-0.0061428603,
-0.028142331,
-0.017987197,
-0.009544498,
-0.035390306,
0.022035975,
0.04279758,
0.00714178,
-0.0046892823,
0.0022782676,
0.014854372,
0.019699631,
-0.0012221006,
-0.015199513,
-0.003600758,
0.008694918,
-0.019646533,
0.016978322,
-0.019646533,
0.024040453,
-0.009318829,
0.008542259,
0.026084755,
-0.011867568,
-0.019261567,
-0.047178227,
0.013414068,
0.01658008,
0.02170411,
-0.012783521,
0.02609803,
0.010347616,
-0.0068563744,
-0.0141906375,
-0.015040217,
-0.024305947,
0.030106984,
-0.023854608,
0.011940578,
-0.000024760397,
0.008728105,
0.011469327,
0.014177362,
-0.026974158,
-0.023363445,
-0.00022670672,
0.0251688,
0.024438694,
0.016526982,
-0.01680575,
0.0037434609,
0.017642055,
-0.031354804,
-0.0015199514,
-0.0010943317,
0.015438458,
-0.0020824661,
0.008927225,
-0.035974395,
-0.62868905,
-0.04077983,
-0.0063818046,
-0.004729106,
-0.0049979184,
0.020018224,
0.004835304,
0.0066738473,
-0.028885713,
0.0054592136,
-0.018385438,
0.019805828,
0.002319751,
0.0014577262,
-0.017057968,
-0.028036132,
-0.009969288,
0.0033651325,
0.016792476,
0.0035775274,
-0.012285721,
0.0040620533,
0.0044967993,
0.021159846,
0.025036054,
0.003328627,
0.02119967,
-0.0315141,
0.03273537,
0.04370026,
-0.020589035,
0.025208626,
-0.018292515,
-0.0043341843,
0.04701893,
-0.016155291,
-0.026350249,
0.016872123,
0.01723054,
0.045505617,
0.004174888,
-0.0009673926,
0.010228144,
-0.015411908,
-0.023403268,
0.026682114,
0.005777806,
0.016898673,
0.007148417,
-0.0034978793,
0.002829167,
-0.025275,
-0.009491399,
-0.014602153,
0.017416386,
-0.018398711,
0.024199748,
-0.03369115,
-0.001800379,
0.009332103,
0.016327862,
0.02581926,
0.010885241,
-0.006922748,
-0.009710431,
0.018013746,
-0.015876522,
0.0050145118,
0.009119708,
-0.00032128883,
0.019805828,
0.020522662,
-0.0022118941,
0.0075134714,
0.008535622,
0.038124893,
-0.0033186711,
-0.0039060758,
-0.029522898,
-0.01955361,
-0.0026781675,
-0.024876758,
-0.017788077,
-0.0059868824,
0.0056516966,
-0.0042744484,
-0.03695672,
0.03408939,
0.006707034,
0.0056450595,
0.031779595,
0.025367921,
-0.021903228,
-0.022288194,
-0.027664442,
0.024438694,
0.012564489,
0.014004792,
-0.02372186,
-0.025805986,
-0.005582005,
-0.026562642,
0.0042014373,
-0.00799136,
0.010493638,
0.013818946,
-0.03406284,
0.022062525,
0.048558794,
-0.044018853,
0.004174888,
-0.009166169,
0.008144019,
-0.013122025,
-0.004612953,
-0.028434373,
0.014376483,
0.0021753889,
0.017960647,
-0.028699867,
0.02496968,
0.008124107,
0.002062554,
-0.024292672,
0.0029104745,
0.021491714,
0.001471001,
-0.025527218,
0.0009176125,
-0.022792632,
0.010772406,
-0.014416307,
0.018969523,
-0.009617508,
0.030053886,
-0.0068829237,
0.023084676,
0.0063917604,
-0.012670686,
-0.024783835,
-0.009524586,
-0.02204925,
0.007447098,
0.014761449,
0.0118742045,
-0.0014311769,
-0.005890641,
-0.011502514,
-0.00038621033,
-0.011774645,
0.013712749,
-0.029629095,
-0.001018832,
0.00979008,
0.015119866,
-0.011495876,
-0.0017290276,
-0.01638096,
0.02496968,
-0.022181997,
0.010360891,
0.01700487,
0.0025852448,
0.0017472802,
-0.0019132139,
-0.005963652,
-0.002115653,
0.002601838,
-0.011290119,
-0.040116094,
-0.0110379,
-0.010274606,
-0.003763373,
0.011057812,
0.0041417014,
0.00851571,
0.013832221,
-0.026257325,
-0.0073010763,
0.00519372,
0.0028673317,
-0.00704222,
-0.00058657513,
0.006929385,
0.04667379,
0.0099892,
0.0149738435,
0.006348618,
0.027213102,
0.017442934,
-0.00342155,
-0.0143233845,
-0.0273724,
0.014164088,
0.0047987984,
0.0034049565,
0.017549133,
0.032071635,
0.02185013,
0.034593828,
0.013367607,
-0.023761684,
0.0071882415,
-0.012252534,
0.019991674,
-0.045187026,
-0.012325544,
-0.020668684,
0.025275,
0.016646454,
0.011694997,
0.0005741301,
-0.010540099,
0.012949455,
-0.00060316845,
0.025155526,
0.01867748,
-0.008734742,
-0.01218616,
-0.0063386615,
-0.028009584,
0.010931702,
0.023429817,
0.000096656295,
0.01720399,
0.023575839,
0.009192719,
0.02579271,
0.0036206702,
0.0055919606,
-0.021544812,
0.012113149,
0.03196544,
0.033053964,
0.0023413224,
0.005104116,
0.026350249,
-0.004692601,
0.013951693,
-0.015199513,
-0.020177519,
-0.0012478203,
-0.01510659,
0.012252534,
0.007254615,
0.0018800271,
0.011641898,
-0.0005421879,
-0.027186554,
0.024266122,
-0.010281242,
-0.011310031,
0.00094582123,
0.022646612,
0.011655172,
-0.014150813,
0.0006048278,
0.028726416,
0.022779359,
0.02315105,
0.0073010763,
-0.043992303,
-0.009132982,
-0.0074603725,
-0.0006886242,
0.0008802775,
-0.013938419,
-0.009252455,
-0.0064614527,
0.009444938,
-0.019805828,
-0.0189297,
0.008887401,
-0.03658503,
0.0012254192,
0.029708743,
-0.011668447,
0.0062922,
0.011668447,
0.0006272288,
-0.023602389,
-0.031673398,
-0.015066766,
-0.0061992775,
-0.0018833458,
-0.022301469,
-0.010487,
0.007201516,
-0.0024906625,
0.024040453,
0.029337052,
-0.0038762079,
-0.0019546973,
0.020708507,
-0.0026167722,
-0.010639659,
0.033956643,
0.00014042127,
0.013951693,
-0.011714908,
-0.024305947,
-0.007938261,
-0.008555534,
-0.013978242,
0.031646848,
0.0038562957,
-0.0051472588,
-0.0124782035,
-0.008455974,
-0.005489082,
0.013911869,
-0.021186396,
-0.01870403,
-0.0033651325,
-0.0049946,
0.013487079,
0.00042188604,
0.021438615,
0.005810993,
-0.0112237455,
0.008197118,
-0.041470114,
-0.026668841,
-0.030133532,
0.025474118,
0.02369531,
-0.013726023,
0.012060051,
0.027903385,
0.015743775,
-0.01121047,
-0.020788155,
0.018159768,
0.005751257,
0.0041582948,
-0.0095710475,
-0.004802117,
0.002814233,
0.03698327,
0.021797031,
0.016288038,
-0.0069625718,
0.0027760684,
0.018783677,
0.006624067,
-0.022620061,
0.013540178,
0.048479147,
-0.009113071,
-0.004533305,
0.007234703,
0.013779122,
-0.016619904,
-0.017469484,
-0.015053492,
0.027146729,
0.00809092,
0.024013903,
-0.018159768,
-0.02819543,
0.006730265,
0.030452125,
0.008031184,
-0.0076594925,
0.020854529,
0.010035661,
0.007924986,
0.009192719,
0.020084597,
0.015212788,
-0.005499038,
0.030558323,
0.013254772,
0.0021206308,
0.04245244,
-0.021797031,
-0.010978164,
-0.003955856,
0.017243816,
-0.007009033,
-0.015916346,
-0.020111147,
-0.027425498,
-0.013314508,
0.020018224,
-0.008655094,
-0.007281164,
0.0048518972,
-0.009610871,
0.0025387832,
-0.010102035,
0.007924986,
-0.026416622,
-0.03400974,
0.015279162,
-0.02040319,
-0.02604493,
0.0070488574,
0.0033302864,
0.027053807,
-0.0059669707,
-0.012597675,
0.0008217859,
0.0052700494,
-0.010121946,
0.0066605727,
-0.010467089,
-0.026960883,
0.007951536,
-0.006365211,
0.007586482,
-0.011814469,
-0.0132614095,
0.015239337,
0.011748095,
0.011495876,
-0.0004924078,
0.005104116,
-0.008117469,
-0.007201516,
0.025779437,
0.010606472,
-0.026934335,
-0.0007861102,
-0.0006048278,
-0.03363805,
0.01241183,
-0.018319065,
-0.014137538,
-0.025606865,
-0.009458212,
0.0073873615,
-0.02434577,
-0.016712828,
0.0147349,
-0.035018615,
0.00087032147,
-0.015053492,
0.017814627,
0.016420783,
0.009624146,
0.0056483783,
0.011495876,
0.0033070557,
-0.008774566,
-0.0058740475,
0.020084597,
-0.015889797,
-0.0041085146,
0.032071635,
0.020549212,
-0.025567042,
-0.0058873226,
0.0013888638,
-0.007101956,
0.025474118,
-0.012956092,
-0.013818946,
-0.032655723,
-0.016102191,
0.014389758,
0.021319143,
0.021093473,
-0.024332495,
0.0064979577,
0.015597754,
0.017894274,
-0.014110989,
0.0033584952,
-0.035018615,
-0.032071635,
0.026536094,
-0.0129361795,
-0.012776883,
-0.026204227,
0.0016668026,
0.021066925,
0.0089405,
-0.017190715,
0.0046295463,
0.0068829237,
0.015478281,
0.023482917,
0.018040296,
0.039452363,
-0.007785602,
0.0157305,
0.017150892,
0.00030158422,
0.019009348,
-0.017469484,
0.01513314,
-0.020960726,
0.017164167,
0.020721782,
0.0017987197,
0.020974,
-0.0035244287,
0.02734585,
0.035390306,
-0.005721389,
-0.0038596145,
-0.01061311,
-0.03626644,
-0.02042974,
0.017881,
-0.026881235,
0.012577763,
-0.050576545,
0.0040288665,
0.015239337,
0.006414991,
-0.015159689,
-0.00786525,
0.016473884,
-0.006902836,
0.0046959193,
0.016911948,
-0.0076926793,
0.0055919606,
-0.0024973,
-0.005060973,
-0.010460451,
0.018265964,
0.016075643,
-0.0020310266,
0.024040453,
-0.015916346,
0.007938261,
0.010991438,
-0.013606551,
-0.018372163,
-0.008356414,
-0.01830579,
-0.028699867,
-0.031699944,
-0.005761213,
-0.029124657,
-0.015876522,
-0.005416071,
-0.0028756284,
0.0040089544,
0.008017909,
0.011369767,
0.02165101,
0.0001640668,
0.022447491,
-0.03191234,
0.04484188,
0.017296914,
-0.007427186,
-0.0293636,
-0.01038744,
0.013400794,
-0.015810149,
0.0140578905,
0.026204227,
-0.0021737295,
0.006385123,
0.014429581,
0.013739298,
-0.008648457,
-0.03862933,
0.023589114,
0.0024143332,
-0.0034846046,
-0.018465085,
-0.010566648,
-0.03618679,
0.01875713,
-0.011170647,
0.00874138,
-0.010845417,
-0.0031328255,
-0.01930139,
0.015226062,
-0.017748253,
0.017867725,
0.0068762866,
-0.018770404,
-0.009166169,
-0.03738151,
-0.01513314,
0.0056516966,
-0.0122127095,
0.011595436,
0.0015788578,
-0.00599352,
0.008681644,
0.0120069515,
-0.0030100346,
0.008210392,
-0.016686277,
0.035974395,
-0.024704186,
0.01450923,
0.016394235,
-0.014495955,
0.00018439366,
0.005681565,
0.002457476,
-0.012146336,
-0.0377001,
-0.0027544969,
0.02689451,
0.024704186,
0.0011233701,
-0.0020210706,
-0.026788313,
-0.0051472588,
-0.026111303,
-0.032124735,
0.005558774,
-0.052381903,
-0.013254772,
-0.017137617,
0.010095397,
0.019035896,
0.010686121,
-0.001271051,
-0.0035974395,
0.030531773,
-0.010440539,
-0.0094980365,
0.014641977,
0.0075931195,
-0.03525756,
-0.020642133,
0.0037036368,
-0.012942817,
0.0059769265,
-0.005791081,
-0.016686277,
-0.031673398,
0.0055654114,
0.019195193,
0.024637815,
-0.010626385,
0.042372793,
-0.010798955,
0.012591038,
-0.0008180524,
0.002764453,
0.036664676,
-0.022115624,
-0.02479711,
-0.0040620533,
-0.03369115,
-0.0030033973,
-0.00023106247,
0.017602231,
-0.023403268,
-0.034673475,
-0.024491793,
0.0023545972,
-0.02462454,
0.0022069162,
0.0015290777,
-0.0069625718,
-0.0106927585,
-0.0074869217,
-0.027478596,
0.019221742,
-0.014641977,
-0.017310187,
0.026655566,
-0.017323462,
0.02185013,
-0.017867725,
0.0007006544,
0.0010959911,
-0.015226062,
-0.020190794,
0.003783285,
-0.028514022,
0.03910722,
0.00094001356,
0.011482602,
-0.017841175,
-0.008728105,
-0.054850996,
0.012265808,
0.0029619138,
0.02042974,
0.0149738435,
0.031168958,
0.0015664127,
-0.011621986,
0.012683961,
0.028832614,
-0.0231245,
-0.031301703,
0.009690519,
-0.0049481387,
0.02247404,
0.0033618137,
0.00060773164,
0.0031394628,
0.015186239,
0.015849972,
0.010599835,
0.008986961,
-0.027425498,
-0.015053492,
-0.0069758464,
0.031407904,
-0.010168408,
0.017164167,
0.00032751134,
-0.03626644,
-0.016394235,
0.00881439,
0.0026184313,
0.0031925614,
-0.008562171,
0.0049481387,
0.010745857,
0.002898859,
0.009717069,
-0.0025835854,
0.0069360225,
-0.020894352,
0.014920745,
0.016221665,
0.0010180024,
0.017150892,
-0.011721546,
0.015226062,
0.013281321,
-0.0006081465,
-0.021345692,
0.0052401815,
0.026907785,
0.014071166,
0.00034348245,
0.008363051,
-0.0060963985,
-0.019965125,
-0.0000014584003,
0.021757208,
-0.023137774,
-0.023058126,
0.042240046,
0.010619747,
-0.020881077,
-0.02252714,
-0.0004911633,
-0.013898594,
-0.018372163,
0.0011374746,
0.014721625,
0.002487344,
-0.016487157,
-0.005751257,
0.01081223,
-0.017018145,
-0.0105002755,
-0.012046776,
-0.023536015,
-0.0021438615,
0.19455378,
0.005688202,
0.007858613,
-0.015119866,
-0.031142408,
-0.007002396,
0.010327704,
-0.0068231877,
0.015239337,
0.02185013,
0.02380151,
-0.001490913,
0.011648536,
0.010646297,
-0.012697236,
-0.007181604,
-0.016739376,
-0.01723054,
-0.0020542573,
-0.034248684,
0.0066406606,
-0.0031029575,
-0.0036638128,
-0.012524664,
0.017217265,
-0.010201595,
-0.011064449,
0.011668447,
0.013380881,
0.0046162712,
-0.016327862,
-0.0067966385,
0.002142202,
-0.020881077,
-0.009425025,
-0.009776805,
-0.0062092333,
-0.026190951,
0.013885319,
0.03398319,
-0.0189297,
-0.016075643,
-0.031036211,
0.0051538963,
-0.022168722,
0.019912027,
-0.0079183495,
-0.0047357436,
0.0025138934,
-0.006507914,
-0.055594377,
0.003640582,
-0.00020119443,
0.00024931517,
-0.004148339,
-0.009531223,
0.032841567,
0.015239337,
-0.023575839,
0.016726103,
0.01768188,
0.0110379,
-0.037939046,
0.019168643,
0.0044038766,
0.027664442,
0.0029237492,
-0.009683882,
0.030956563,
-0.029310502,
0.009637421,
-0.012829982,
0.0050476985,
-0.005698158,
-0.0013863748,
-0.033399105,
0.017841175,
0.009358652,
0.016035818,
0.0009059972,
0.000043246433,
-0.022965204,
-0.02984149,
0.032602623,
-0.030399026,
-0.030160083,
0.019965125,
0.008920588,
0.0032921217,
0.01723054,
-0.02125277,
0.005216951,
-0.0015929621,
-0.003925988,
0.026482996,
0.03823109,
0.0042910418,
-0.0011092658,
0.015226062,
-0.013214948,
-0.0045963596,
0.061116647,
0.01867748,
-0.008442699,
0.00083464576,
0.0055056754,
-0.0057446198,
-0.018226141,
0.018717304,
-0.02222182,
0.015385359,
-0.023403268,
-0.0038894825,
-0.007586482,
0.01592962,
0.01038744,
0.007281164,
-0.01083878,
0.009252455,
0.00037189858,
-0.009411751,
-0.013978242,
0.017668605,
0.021797031,
-0.0009673926,
-0.003501198,
-0.02901846,
-0.0015398634,
-0.013540178,
-0.024425419,
0.013095476,
0.0010180024,
-0.005990201,
0.026058204,
0.013951693,
-0.028460924,
0.007181604,
0.010400715,
-0.00809092,
0.010108672,
0.0070289453,
-0.0042810855,
0.021544812,
0.008124107,
-0.0021587955,
-0.02462454,
0.031646848,
0.021504989,
-0.0136331,
-0.01890315,
-0.032469876,
-0.012624225,
0.0005177127,
-0.025593592,
0.016394235,
-0.027531695,
-0.012471566,
-0.0061594537,
-0.00841615,
0.017310187,
-0.038018696,
0.022845732,
0.017841175,
-0.018982798,
-0.014469406,
-0.018013746,
-0.16694243,
-0.012464928,
-0.011734821,
-0.011880842,
0.020867804,
0.032496426,
0.021438615,
0.0018767085,
-0.006680485,
0.026031656,
0.030478675,
0.01638096,
-0.05296599,
-0.0137923965,
-0.0055720485,
-0.009212631,
-0.02242094,
0.03897447,
0.05161197,
-0.0010777385,
0.027213102,
-0.019022623,
0.017363288,
-0.024385594,
-0.0048452597,
-0.0065908805,
-0.01510659,
-0.0012801774,
-0.014761449,
-0.0056716087,
-0.012298995,
0.007725866,
0.02042974,
-0.0063685295,
-0.0067203087,
0.009371927,
0.011090999,
0.0058441795,
-0.0050476985,
0.012730422,
0.033505302,
-0.0022118941,
0.028460924,
0.002928727,
0.0063320245,
0.01600927,
0.015664127,
-0.018425262,
0.013188398,
0.0016419125,
0.026350249,
0.004486843,
0.020695232,
0.0002926653,
0.011714908,
0.009205993,
0.013155212,
0.011787919,
0.02037664,
0.00061519863,
-0.033584952,
-0.029522898,
0.015624303,
-0.004314272,
-0.009610871,
-0.03658503,
-0.012657411,
-0.00082925294,
-0.007626306,
0.01810667,
-0.014469406,
-0.0033004184,
-0.008535622,
-0.015717225,
0.017774802,
0.020788155,
-0.010155133,
0.032921217,
-0.02057576,
-0.020058047,
-0.00096573326,
0.01895625,
-0.008621908,
-0.015849972,
-0.023536015,
0.0043507777,
-0.0007031434,
-0.011568887,
0.020058047,
-0.018066846,
-0.016248213,
-0.01950051,
0.001815313,
-0.010181683,
0.010360891,
0.025965283,
-0.0029038372,
-0.0035476594,
-0.007194879,
0.014336659,
0.009551135,
-0.023814783,
-0.02352274,
0.015995994,
0.02287228,
-0.021903228,
-0.004480206,
0.009212631,
0.04622245,
-0.015398634,
-0.019341215,
0.0178279,
0.03857623,
0.025991831,
0.012823345,
0.013254772,
-0.014164088,
0.006760133,
0.03573545,
-0.028381275,
0.058143117,
0.0018916425,
-0.023708586,
0.009816629,
0.009975925,
0.0071616923,
-0.12106512,
-0.0009176125,
-0.015518106,
-0.0033551764,
-0.013951693,
0.036425732,
0.018265964,
0.025062604,
-0.02564669,
0.0025902227,
-0.009511312,
-0.016447334,
-0.011628623,
-0.009843178,
0.025633415,
-0.0007309373,
0.012876444,
-0.017575681,
-0.025805986,
0.015080041,
0.0007251296,
0.012776883,
-0.019341215,
-0.028965361,
0.013752573,
-0.00946485,
-0.03950546,
0.009524586,
0.022022702,
0.014894196,
0.013175124,
-0.012504753,
0.013141938,
0.0038197904,
-0.007686042,
0.0019845653,
-0.03318671,
-0.005336423,
0.033797346,
-0.023084676,
0.0022815864,
0.020310266,
0.0038397023,
0.009896277,
0.008568808,
-0.009398476,
-0.026867962,
0.008708193,
0.0418949,
-0.013573364,
-0.0377001,
-0.029655645,
-0.034222137,
0.0059371023,
0.0023745091,
-0.03236368,
-0.0013191717,
0.024757287,
-0.01618184,
-0.005286643,
-0.019274842,
0.0037301863,
0.015345535,
0.0030697708,
0.008601995,
-0.013898594,
-0.007626306,
-0.012531302,
0.022686435,
-0.031699944,
-0.007121868,
-0.029257404,
-0.036425732,
-0.013075564,
-0.007559933,
0.012617587,
-0.018226141,
-0.016487157,
0.008555534,
-0.015411908,
-0.006949297,
-0.0058176303,
0.03066452,
0.015172964,
0.041496664,
0.016447334,
0.014575603,
-0.019659808,
-0.013055651,
0.0028109143,
0.0036638128,
0.022168722,
-0.013712749,
-0.024359046,
0.0011017987,
0.002912134,
-0.023655487,
-0.012511389,
0.020721782,
0.03066452,
-0.020788155,
0.0036870434,
-0.06424947,
0.0021919822,
0.013055651,
-0.002132246,
-0.01575705,
0.00076329435,
0.0006732754,
-0.008017909,
-0.0012669027,
0.012352093,
-0.0056251474,
0.018265964,
-0.025659963,
0.015743775,
-0.019938575,
0.005605235,
0.0231245,
-0.014641977,
0.01768188,
0.023084676,
-0.0021339054,
0.010307793,
-0.012591038,
0.025009505,
-0.0014950613,
0.017814627,
-0.024106827,
0.04468259,
-0.0128631685,
-0.017642055,
0.015398634,
-0.04792161,
-0.0023230696,
0.0094980365,
0.011655172,
-0.012391917,
0.0019181919,
0.024199748,
0.020987276,
0.037089467,
-0.028699867,
-0.040062997,
-0.0052700494,
0.010360891,
-0.02479711,
0.008144019,
-0.002389443,
0.019142095,
0.0018634337,
-0.017429661,
0.008296678,
0.005495719,
-0.0019464005,
-0.014150813,
0.0015821764,
0.0136862,
0.022686435,
-0.011575525,
0.006063212,
0.0053729285,
0.013387519,
0.011482602,
0.017668605,
0.0074338233,
0.0029088152,
-0.007181604,
-0.014270285,
0.0008570468,
-0.0022268284,
-0.020084597,
-0.033080515,
0.016473884,
-0.01198704,
0.024704186,
0.002092422,
-0.00077242067,
-0.0080510955,
0.004267811,
-0.005910553,
-0.015531381,
0.0014079462,
-0.014987119,
0.0060399813,
0.00090184883,
0.02808923,
-0.0062291455,
-0.010420627,
0.035576154,
-0.013195036,
0.0074935593,
-0.019075722,
0.015584479,
0.012026864,
0.0068298248,
0.017947372,
0.00043640524,
0.00078776956,
-0.0014967206,
0.03825764,
0.053204935,
0.007606394,
-0.0017738297,
-0.008044459,
-0.028434373,
-0.02607148,
0.014549054,
-0.040381588,
-0.018863326,
-0.015823424,
0.0050111935,
0.047815412,
0.0053928406,
-0.0065112324,
0.00204762,
-0.015252612,
-0.013845496,
0.0033501985,
0.0012254192,
-0.015172964,
0.028673317,
-0.0049912813,
0.038071793,
-0.0039425814,
-0.0020608946,
0.015013668,
0.0033883632,
0.017071243,
-0.014947294,
0.020456288,
-0.026575917,
0.0011914029,
-0.022951929,
-0.013314508,
-0.011190559,
-0.040912576,
-0.017602231,
0.007559933,
0.002991782,
-0.013453892,
0.07279837,
0.009511312,
-0.018199593,
0.0058342237,
-0.030425576,
0.0041085146,
0.024465242,
-0.0032522976,
0.0011540678,
-0.020416465,
0.0007628795,
-0.016248213,
0.030319378,
-0.050762393,
-0.019142095,
-0.004387283,
-0.003833065,
-0.008230304,
-0.016288038,
0.0059570144,
0.008104195,
-0.0016543575,
0.028859163,
0.026589192,
0.0020044772,
0.0027113543,
0.026775038,
-0.006547738,
0.0036804061,
-0.018942975,
-0.009531223,
0.0013465508,
-0.040169194,
-0.020920902,
-0.0033817259,
-0.017841175,
-0.014349934,
-0.022062525,
0.01955361,
0.0061096735,
-0.016049093,
-0.0022865643,
-0.004257855,
-0.010785681,
0.024478517,
-0.010672846,
-0.043116175,
-0.006756814,
0.009776805
] |
MOTIVATION Accurate alignment of high-throughput RNA-seq data is a challenging and yet unsolved problem because of the non-contiguous transcript structure, relatively short read lengths and constantly increasing throughput of the sequencing technologies. Currently available RNA-seq aligners suffer from high mapping error rates, low mapping speed, read length limitation and mapping biases. RESULTS To align our large (>80 billon reads) ENCODE Transcriptome RNA-seq dataset, we developed the Spliced Transcripts Alignment to a Reference (STAR) software based on a previously undescribed RNA-seq alignment algorithm that uses sequential maximum mappable seed search in uncompressed suffix arrays | [
-0.057793558,
-0.012940192,
0.0013196723,
-0.023745494,
0.0010244031,
0.015150837,
-0.0015236922,
0.0032694817,
-0.031045442,
-0.013732168,
-0.01364264,
0.019007413,
0.005691894,
0.0055128387,
0.010715773,
0.02764339,
0.00953814,
-0.0017595631,
-0.018938547,
-0.011555957,
-0.022588521,
0.009868704,
-0.026403777,
-0.002966465,
-0.0039013405,
0.007905982,
0.012912645,
-0.027781125,
-0.032009587,
-0.019875143,
0.016404225,
-0.013677074,
-0.013263869,
-0.011693692,
-0.03225751,
-0.007479004,
-0.014613671,
0.00061119854,
0.032422792,
-0.020357216,
0.011060111,
0.018731944,
0.010908603,
-0.009889364,
0.007775134,
0.003822143,
0.00807815,
-0.015922152,
-0.02239569,
0.008622204,
-0.0015839512,
0.004927465,
-0.031486195,
-0.00012686674,
0.010474738,
0.0074652308,
0.005412981,
0.0061498624,
-0.0225472,
-0.025150388,
-0.0025102182,
0.006642265,
-0.031403553,
0.026486417,
-0.015467627,
-0.010392097,
-0.021459095,
-0.012237744,
0.008787486,
-0.00156243,
0.027739804,
0.023717947,
-0.0015383265,
0.018208552,
0.014765179,
-0.017478557,
0.012905759,
-0.0064356625,
0.004204357,
0.003037054,
0.018181004,
0.0013747662,
0.0032694817,
0.009159369,
-0.004600345,
0.0074583436,
0.00892522,
0.016831202,
0.00017862492,
0.00069383945,
0.020288348,
0.02594925,
0.03424089,
0.00090302434,
-0.015426307,
-0.019930238,
0.02195494,
0.029613,
-0.0058537326,
-0.01753365,
-0.01626649,
-0.016872523,
-0.031128082,
-0.006959055,
-0.018690623,
0.0029423614,
0.013098587,
-0.012203311,
0.004376526,
0.0029371963,
-0.0014737633,
0.010936149,
-0.012106896,
0.019613447,
0.026789434,
-0.018208552,
0.0350673,
0.0036912947,
-0.0040597357,
-0.018511567,
0.019985331,
-0.0025360435,
-0.0016183848,
-0.019393072,
0.015536495,
0.022987952,
-0.019200243,
-0.0022967292,
0.006642265,
-0.009710309,
0.030108845,
0.009283331,
0.019021187,
0.01064002,
-0.0184427,
-0.005895053,
0.0020264245,
-0.029585453,
-0.021872299,
-0.030301673,
-0.004008085,
0.03377259,
-0.015811965,
-0.0051340675,
0.01247878,
0.0124168,
0.00056557386,
-0.010137287,
0.025439633,
0.005674677,
0.018511567,
-0.015068196,
-0.008443148,
0.0005440528,
0.014475936,
0.01567423,
-0.001425556,
0.005185718,
-0.012706043,
-0.020494951,
-0.00036155406,
0.0121964235,
0.010674453,
0.010330116,
0.01607366,
0.03479183,
-0.014558577,
-0.0014324428,
-0.013759715,
-0.02487492,
0.011741899,
0.020990796,
-0.037601624,
0.0072173076,
0.0077475873,
0.0077407,
-0.014558577,
0.031293366,
-0.009613895,
-0.020522498,
0.011308034,
0.0013592711,
0.025301898,
0.025632462,
-0.024337754,
-0.0017268511,
0.0058434024,
0.005106521,
0.024764732,
-0.014186692,
0.0055403854,
-0.006304814,
-0.0004945543,
-0.017451009,
-0.6382083,
-0.028676402,
-0.0032815335,
-0.016004793,
-0.0036327576,
0.005006663,
0.011941615,
0.010529832,
-0.008835693,
0.030026205,
-0.014889141,
-0.0010596977,
0.013525565,
-0.0314311,
-0.038290296,
-0.014737632,
0.023828134,
-0.0391718,
-0.00011158678,
0.01800195,
-0.04382724,
-0.005199492,
0.013732168,
0.0065114163,
0.0049825595,
-0.002642788,
0.019640993,
-0.016652146,
-0.015825737,
-0.00920069,
-0.034681644,
0.0009994387,
0.01871817,
-0.0018026052,
0.051870957,
-0.010887942,
-0.00015355287,
0.01332585,
0.011948501,
0.015205931,
0.002341493,
-0.02388323,
0.024255112,
0.010736434,
-0.0043902993,
0.011115205,
0.013057266,
-0.0055197254,
0.001052811,
-0.019200243,
-0.017547423,
-0.0018645859,
-0.0076993797,
0.0019110715,
-0.0055782627,
-0.0028717723,
0.03099035,
-0.0071828743,
0.010646907,
-0.008553336,
-0.009868704,
0.008815032,
-0.01599102,
-0.032395244,
-0.01015106,
-0.0055300556,
-0.0056023663,
0.0094692735,
0.013043493,
-0.0122859515,
0.03052205,
0.024117379,
0.008670411,
-0.017602518,
-0.0016846698,
0.0455627,
0.006397785,
0.006625048,
-0.012079349,
0.0033590095,
-0.008622204,
0.016004793,
-0.040273678,
0.0023862568,
0.015564041,
0.011597277,
-0.03107299,
0.0005419007,
0.0248336,
-0.004562468,
0.002105622,
-0.014861594,
-0.005729771,
-0.04798683,
-0.021032115,
0.006952168,
-0.016018566,
0.008484469,
0.023635305,
-0.025632462,
-0.025770197,
0.0018198221,
0.017960628,
-0.0005328618,
0.02428266,
0.0087323915,
0.0106813405,
-0.007072686,
0.037849545,
-0.005185718,
0.026761888,
-0.010323229,
-0.004276668,
-0.011411335,
0.0038944539,
-0.030439408,
0.016597053,
0.017271955,
-0.0100339865,
-0.022671161,
0.0023328846,
0.0023707617,
0.0011363127,
-0.004610675,
0.005998354,
0.0033090806,
0.007830228,
-0.020632686,
0.009062955,
0.00975163,
0.00020401979,
-0.02499888,
0.030163938,
-0.019930238,
0.02282267,
-0.0087737115,
0.005495622,
0.024695864,
-0.0062118433,
-0.013821695,
0.0029612998,
0.0074376836,
0.004266338,
-0.016280264,
-0.026761888,
-0.017189313,
-0.026748113,
-0.0014496596,
0.03768426,
-0.03032922,
-0.014172919,
0.016528185,
-0.029530358,
0.012974625,
-0.0032660384,
-0.012430573,
-0.030687332,
-0.032285057,
-0.017230634,
-0.044708744,
0.001398009,
0.020260802,
-0.013780375,
0.021211172,
0.008195225,
-0.012389253,
0.011845199,
0.017877987,
-0.034020517,
-0.027849993,
0.028400933,
-0.02933753,
-0.007093346,
-0.0010312899,
-0.014958008,
0.015495175,
-0.030549597,
0.0047897305,
0.014007637,
-0.011349354,
-0.008188339,
0.0323126,
-0.00985493,
-0.019241562,
0.011060111,
0.018194778,
0.023470024,
-0.010949923,
0.015426307,
0.015026876,
0.003026724,
-0.0052063786,
-0.026486417,
0.049694747,
-0.0027030471,
0.008615317,
0.0051891617,
-0.003997755,
-0.004731193,
0.009152483,
0.034185797,
0.017877987,
0.001497006,
-0.008243432,
-0.006008684,
-0.010316343,
0.004868928,
-0.0072035342,
0.005399207,
-0.008952768,
-0.014000751,
-0.0121964235,
-0.006728349,
-0.009737856,
0.025329445,
0.014228013,
-0.006273824,
0.013415378,
0.008677297,
0.0112873735,
-0.026210947,
-0.008704845,
0.017120445,
-0.01954458,
-0.0037601623,
0.029778281,
0.012396139,
0.016128754,
0.020260802,
0.0077889077,
0.0025171048,
0.01607366,
0.0023897002,
0.0109430365,
0.025935479,
0.00621873,
0.03925444,
-0.01603234,
0.018855905,
0.0015658734,
-0.0023122244,
-0.00170533,
-0.010757094,
-0.0327809,
0.021059664,
0.0029044843,
0.017781572,
0.041127637,
0.0031455203,
-0.012409912,
-0.0035914371,
-0.0011199567,
-0.008443148,
0.0015564042,
0.0050169933,
-0.015453854,
0.0063082576,
0.010433417,
0.054460373,
0.029778281,
0.006607831,
0.022519654,
-0.002028146,
-0.015605362,
0.0029802385,
-0.0064563225,
0.012451233,
0.0039323308,
-0.004121716,
0.0028235652,
-0.0046795425,
-0.017079126,
0.018649302,
-0.019833824,
-0.0057091108,
0.010832848,
-0.012471894,
0.012692269,
0.017657612,
-0.0053923205,
-0.020426083,
-0.01863553,
0.061374664,
0.018318739,
-0.015247251,
-0.027574522,
-0.015329892,
-0.007589192,
0.00017571957,
-0.015095743,
0.01907628,
0.009248897,
0.0013704621,
0.011528409,
-0.010123514,
0.005561046,
0.044598553,
-0.02191362,
0.027478108,
-0.00860843,
0.013608206,
-0.0065837274,
0.0038186996,
-0.030411862,
0.040218584,
-0.000008682408,
-0.0108535085,
-0.036609933,
0.0032092228,
-0.0060982117,
0.01340849,
-0.02057759,
-0.00560581,
-0.009992666,
-0.0024189688,
0.009235124,
-0.006886744,
-0.0014703198,
0.011576617,
0.0045796847,
-0.00082640926,
-0.022161542,
0.02787754,
0.031376004,
0.020908155,
0.02408983,
-0.008870127,
0.005412981,
-0.009551914,
0.017203087,
-0.020605138,
-0.022381919,
0.009111162,
-0.02231305,
-0.029585453,
0.00036736476,
0.024709638,
-0.005702224,
-0.007961076,
0.027849993,
0.0034537022,
-0.061429758,
-0.017754026,
0.0038669067,
0.010536718,
0.011514636,
0.011562843,
0.028208103,
0.021899845,
-0.018249871,
-0.0054715183,
0.0047897305,
0.007616739,
-0.020949475,
0.0040838392,
0.004211244,
-0.010027099,
0.025053974,
0.005988024,
-0.006204956,
0.030797519,
-0.024819825,
0.011487089,
0.022244183,
0.01808459,
0.008133245,
0.0018318739,
0.014613671,
0.009248897,
-0.023332288,
-0.011459542,
0.024296433,
-0.015922152,
-0.010130401,
0.024985107,
-0.01884213,
-0.016762335,
-0.008112584,
0.0009279888,
-0.0036499742,
-0.020136839,
-0.004590015,
-0.0055025085,
-0.029750735,
0.0059535904,
-0.030136392,
0.012933305,
-0.0061326455,
0.0015081969,
0.001025264,
-0.004775957,
0.007905982,
-0.014627445,
0.016046114,
-0.018304966,
-0.005488735,
-0.03746389,
-0.0012163712,
0.0082985265,
0.0032849768,
0.014847821,
-0.024737185,
0.0012051802,
0.02195494,
-0.03404806,
0.003345236,
-0.0066870283,
-0.03834539,
-0.019640993,
0.0017991619,
0.019833824,
-0.019778728,
-0.007499664,
0.008202112,
0.011005017,
-0.009517481,
0.025274351,
0.006959055,
0.0120242555,
0.040025756,
0.025935479,
0.02756075,
0.018070817,
-0.014792726,
-0.004996333,
-0.034323532,
-0.0131950015,
-0.024778506,
-0.0014324428,
-0.017065352,
-0.0099857785,
0.00031205558,
0.009744743,
-0.02053627,
0.012299725,
0.0028872674,
-0.00057762564,
0.00223647,
0.02692717,
-0.004173367,
-0.009152483,
0.026348682,
0.0015710385,
0.014654991,
-0.01785044,
0.012100009,
0.02464077,
0.0075203246,
-0.0083123,
0.015302345,
0.003970208,
-0.0104196435,
-0.01571555,
-0.003832473,
-0.0041286033,
0.040328775,
0.028566215,
-0.024172472,
0.0113769015,
-0.031541288,
-0.0031162517,
0.003767049,
-0.013139907,
-0.007926642,
-0.016831202,
0.007041696,
-0.010825962,
-0.0043524224,
-0.008415601,
-0.016844977,
-0.024062283,
0.014985555,
0.006721462,
0.032918636,
-0.0052408124,
0.009131823,
-0.020894382,
-0.014958008,
-0.0099857785,
-0.017630065,
-0.01360132,
0.0069177346,
0.042036686,
-0.0014651548,
0.043937426,
-0.01618385,
-0.005994911,
0.017630065,
0.024076058,
-0.008023057,
-0.01275425,
0.0023501015,
-0.006962498,
-0.002692717,
0.03404806,
-0.021596828,
0.000035886394,
-0.023387384,
0.018112136,
0.0152747985,
-0.021624377,
-0.024902467,
0.017974403,
-0.026899623,
-0.038207658,
0.004672656,
0.0045314776,
-0.0037601623,
-0.025839064,
-0.0004338649,
0.009545027,
-0.0076580592,
0.039116707,
0.0078095677,
0.022808896,
0.019599674,
0.008649751,
0.010543605,
0.025839064,
-0.023897002,
0.00076356775,
-0.046774767,
0.013360283,
0.019090055,
-0.005499065,
0.015109517,
0.01389745,
-0.00097361347,
0.0076373992,
0.0100339865,
-0.01590838,
-0.015811965,
-0.010805301,
-0.031100536,
0.0033882782,
-0.014324428,
-0.012995286,
-0.02925489,
-0.01457235,
-0.016225168,
-0.0009985779,
0.016486865,
-0.015288572,
-0.027078677,
0.019930238,
0.0037463887,
0.030797519,
0.005010106,
-0.001168164,
0.017988175,
-0.010226815,
-0.04481893,
-0.009834271,
0.00024254252,
-0.011604164,
0.022023808,
0.021376453,
-0.020370988,
-0.0123272715,
0.0177678,
-0.007093346,
-0.029943563,
-0.053275853,
0.0064253323,
0.0013351676,
0.013015946,
-0.021404,
-0.00953814,
-0.006301371,
0.025660008,
-0.024558129,
0.036141634,
-0.012113783,
-0.0061292024,
-0.0108535085,
0.0243653,
0.0024998882,
0.0057435445,
-0.0049756723,
-0.025205484,
-0.02326342,
0.0041905837,
-0.018277418,
-0.009916912,
0.015550268,
0.0455627,
-0.009579461,
0.010350776,
0.010295683,
0.010392097,
0.002313946,
-0.011025677,
-0.008842579,
0.03771181,
-0.045865715,
-0.004862041,
0.010233701,
0.007265515,
-0.00065897533,
0.037821997,
-0.013181228,
-0.011466429,
-0.018580435,
0.02262984,
0.0136701865,
-0.0014238344,
0.020494951,
-0.030191487,
0.008264093,
-0.0055300556,
-0.012396139,
-0.0031868408,
0.005202935,
-0.054322638,
-0.029365076,
0.004858598,
0.0075547583,
0.03696804,
0.006707689,
0.020123066,
-0.011480202,
0.030466955,
-0.03892388,
0.009262671,
0.021307586,
-0.013222548,
-0.035122395,
0.020233255,
-0.019489486,
-0.031679023,
0.013787261,
-0.030935254,
-0.028139235,
0.020274574,
0.0037636056,
-0.004459167,
0.011907181,
-0.019971557,
0.0041974704,
-0.006693915,
-0.00507553,
-0.0038737936,
-0.019517032,
0.0067696692,
-0.024144925,
-0.0056884508,
0.0155778155,
-0.0064391056,
0.0034244335,
-0.0030646012,
-0.018897226,
0.0024912797,
-0.010412757,
-0.024076058,
0.0061601927,
0.0011965717,
-0.010839735,
0.004479827,
0.01218265,
-0.008112584,
-0.018621756,
0.009999553,
-0.0020574147,
0.005898496,
-0.009324651,
-0.00035789548,
0.0041802535,
-0.0008388915,
-0.019957785,
0.0039116708,
0.0006645708,
0.0051616146,
-0.035370316,
-0.007014149,
-0.0051340675,
0.018387606,
0.0148065,
-0.032588072,
-0.014517256,
0.007396363,
-0.060438067,
-0.01273359,
0.012664722,
0.026610378,
0.03988802,
0.04063179,
0.02546718,
0.0323677,
-0.017795347,
-0.0036086538,
-0.008174566,
-0.011597277,
0.013126134,
0.01884213,
-0.0064253323,
0.006184296,
-0.049887575,
-0.017437236,
0.015977247,
0.012830004,
-0.0065699536,
0.022051355,
0.009765403,
0.0024155255,
0.010708887,
0.015178384,
0.005258029,
0.0035225695,
0.026472645,
-0.050686438,
-0.011728125,
0.029613,
-0.008450035,
-0.035563145,
0.0043455353,
0.0020729098,
0.0060327877,
0.0099857785,
-0.012830004,
-0.01962722,
-0.0022519652,
-0.0028115131,
-0.003476084,
0.017836668,
0.00063358044,
0.018649302,
0.00892522,
-0.018057043,
0.0026892736,
-0.013677074,
0.0010700278,
-0.0005982859,
0.007561645,
-0.014517256,
-0.01567423,
-0.0038737936,
-0.0055507156,
0.0023793702,
-0.0012525265,
-0.006542407,
-0.0043007717,
-0.021596828,
0.00043687783,
-0.0010261248,
-0.00034691973,
-0.003794596,
0.010667566,
-0.02096325,
-0.005364774,
0.011404448,
-0.008594656,
-0.022202862,
0.034130704,
-0.024020962,
-0.014654991,
-0.013863016,
0.005378547,
-0.0033676177,
-0.033001278,
0.03528768,
0.19238809,
-0.014503483,
0.0038255863,
0.025480952,
0.01121162,
-0.024296433,
0.024296433,
0.009427953,
-0.027849993,
0.009841157,
0.004407516,
-0.011714351,
0.0016571227,
-0.013208775,
0.024585675,
0.004562468,
-0.033194106,
-0.02637623,
-0.008828806,
-0.0017561198,
-0.007396363,
-0.00059742504,
-0.022175316,
-0.013429151,
0.03352467,
0.008215886,
-0.017795347,
-0.010116627,
-0.0020935703,
0.015329892,
-0.026224721,
0.00092626706,
0.018263645,
0.010867282,
-0.007072686,
0.016886296,
0.01875949,
0.019475712,
-0.014159146,
0.0052063786,
-0.017382141,
0.0026307362,
-0.0006546711,
-0.0126302885,
0.011576617,
0.0015047536,
-0.015302345,
0.011149638,
-0.020233255,
0.004655439,
-0.014875367,
-0.0053578867,
0.0036017671,
0.02373172,
0.0036086538,
-0.0038944539,
0.011500862,
0.021376453,
0.011232279,
0.01590838,
0.003990868,
0.003279812,
-0.016445545,
0.0007226777,
-0.021362681,
0.023800587,
-0.022023808,
0.02842848,
0.029916016,
-0.009978892,
0.01121162,
-0.014475936,
-0.018263645,
0.008697958,
-0.046774767,
-0.014737632,
0.043937426,
0.008305414,
0.0062084,
0.0141040515,
0.009848044,
-0.014586124,
-0.016638374,
-0.009545027,
-0.0109430365,
-0.03625182,
0.011335581,
-0.004056292,
-0.021858526,
0.011005017,
0.014847821,
0.007430797,
-0.017106673,
-0.020439856,
-0.008649751,
0.0002319972,
-0.012644062,
0.01607366,
-0.0051891617,
-0.025356991,
-0.04019104,
0.050548702,
-0.0077889077,
0.009910025,
-0.018015722,
0.006156749,
-0.003997755,
0.014503483,
0.00040890044,
-0.017423462,
0.0066043874,
-0.038290296,
0.02487492,
-0.01512329,
0.023084367,
0.028814137,
0.028759044,
-0.034378625,
0.051870957,
-0.0054198676,
-0.011803879,
-0.008126358,
-0.0155778155,
0.022450786,
0.0006538103,
-0.015894605,
-0.017685158,
-0.0112873735,
-0.020426083,
-0.023483798,
0.009097389,
0.0013015947,
0.022354372,
0.0035742202,
-0.0026875518,
-0.02787754,
-0.023470024,
-0.0058916095,
-0.012334159,
0.012003595,
-0.0022846772,
-0.008243432,
0.0067765564,
0.01789176,
-0.006573397,
0.01453103,
0.01192784,
0.008897673,
-0.013635754,
0.01010974,
-0.009889364,
0.009703422,
-0.0008242572,
0.0066216043,
-0.0025171048,
-0.01749233,
-0.03214732,
-0.049336635,
-0.020646458,
0.015192158,
-0.03754653,
0.010667566,
0.029998656,
0.013725281,
0.0056781205,
-0.005543829,
-0.1758599,
-0.011776333,
0.0031816757,
-0.043441582,
0.018208552,
0.008649751,
0.030191487,
0.021183625,
-0.0019420618,
0.010350776,
0.012836891,
-0.005237369,
-0.036472198,
-0.0073894765,
0.012664722,
0.027588297,
0.0050686435,
-0.0013515236,
0.01677611,
0.010233701,
0.010543605,
-0.023924548,
0.00032733555,
-0.0143657485,
-0.003126582,
-0.00562647,
0.0019403402,
0.015963472,
-0.0027942965,
-0.023869455,
-0.016762335,
0.0024843928,
0.01121162,
-0.020426083,
0.0075478717,
0.024819825,
-0.0076580592,
0.009186917,
-0.023222102,
0.033304293,
0.024668317,
0.021197397,
0.00447294,
-0.008787486,
0.018456474,
0.01982005,
0.015688002,
-0.0207291,
0.024420394,
-0.006301371,
0.0004743245,
-0.017864214,
0.010832848,
0.009717196,
0.034323532,
0.010536718,
-0.0090354085,
0.0337175,
0.021114757,
-0.027491882,
-0.010447191,
0.008250319,
0.02878659,
-0.03024658,
-0.021142304,
-0.013594433,
0.0023776484,
0.014172919,
-0.016789882,
0.01859421,
-0.025453405,
0.0149304615,
-0.0125889685,
-0.0064907563,
0.006662925,
0.016417997,
-0.025412086,
0.02227173,
0.014228013,
-0.007837115,
-0.011679918,
0.022244183,
-0.007609852,
-0.006959055,
0.014668765,
-0.0067352355,
0.018304966,
0.014916687,
-0.0070003755,
-0.00862909,
0.029420171,
-0.01186586,
0.005433641,
-0.012031142,
0.026114533,
0.011941615,
0.009317765,
-0.0069728284,
0.022808896,
-0.01840138,
0.03187185,
0.011259827,
-0.024076058,
0.024695864,
0.025356991,
0.025343219,
-0.0042353477,
-0.021693245,
0.015894605,
0.0069452813,
-0.035866164,
-0.010013326,
-0.0032488215,
0.011232279,
-0.004996333,
0.024392847,
-0.01986137,
-0.01926911,
0.012444346,
-0.028731497,
0.04699514,
-0.00533034,
-0.02278135,
0.02163815,
0.00013859573,
-0.013739054,
-0.12550402,
-0.01639045,
0.030191487,
0.004479827,
-0.012320385,
0.018291192,
0.0015202487,
0.03454391,
-0.026706794,
0.025660008,
-0.013201889,
-0.028759044,
-0.013394717,
-0.02218909,
0.0014229735,
0.017740253,
-0.012995286,
-0.012279064,
-0.009379745,
0.026224721,
0.001754398,
-0.006786886,
0.019007413,
-0.020205706,
0.00266517,
0.0113769015,
-0.02278135,
0.0054060942,
0.021899845,
0.0043386486,
-0.009228237,
-0.02582529,
0.020825515,
-0.0076787197,
-0.008704845,
-0.0016442102,
-0.030219033,
-0.015040649,
0.0019541136,
-0.010674453,
-0.01453103,
0.017795347,
0.0036637478,
-0.004025302,
-0.0049997764,
-0.005509395,
0.011363127,
0.027753578,
-0.01690007,
-0.016679695,
-0.01808459,
0.00076012436,
-0.033194106,
-0.017340822,
0.018070817,
-0.00325743,
-0.0009830827,
-0.00071923435,
0.012816231,
-0.00474841,
-0.0011655814,
-0.0000620883,
0.014048958,
0.00565746,
0.006146419,
-0.01666592,
-0.01453103,
-0.014599897,
0.019172695,
-0.010144174,
-0.0061223153,
0.0126302885,
-0.015550268,
0.008456922,
-0.025577368,
-0.0038531332,
-0.04917135,
-0.033139013,
0.0152747985,
0.002479228,
0.0003004342,
-0.019668542,
0.01305038,
-0.010867282,
-0.01245812,
0.020205706,
-0.011032564,
-0.007527211,
0.013504905,
-0.021596828,
-0.0028941543,
0.028139235,
-0.021596828,
0.0028046265,
-0.021348907,
-0.0078095677,
-0.014668765,
0.0020866834,
0.00038372076,
-0.0034072166,
-0.030274127,
0.00953814,
-0.06506596,
-0.0021297256,
0.01066068,
-0.0062428336,
-0.007286175,
-0.02783622,
0.015192158,
0.0070589124,
-0.011480202,
0.00094950985,
-0.016721014,
-0.014228013,
-0.027147545,
-0.0018904113,
-0.010667566,
0.0062428336,
0.013945657,
0.01789176,
0.023180781,
0.023745494,
0.0045693545,
0.0013205332,
0.0076993797,
0.032643165,
-0.015026876,
0.0030749312,
-0.0048276074,
0.038207658,
-0.011046338,
-0.0068936306,
0.008381167,
-0.008463808,
-0.017051578,
0.011342468,
-0.0077613606,
0.0048895883,
0.023676626,
0.021789659,
0.018773265,
0.010316343,
-0.008560223,
-0.019792503,
0.0020040425,
0.012237744,
-0.0031902841,
0.014627445,
0.001749233,
0.005247699,
-0.005347557,
-0.008938993,
0.04244989,
0.01962722,
0.014000751,
-0.007341269,
-0.013553113,
-0.031376004,
0.0153161185,
-0.0030955914,
0.0016519577,
-0.030632237,
0.048868336,
0.0062944843,
-0.005099634,
0.0049481257,
-0.0041595935,
-0.008932107,
-0.018194778,
-0.0056368,
0.013015946,
-0.04944682,
-0.018222325,
0.0066491514,
0.00045667723,
0.004070066,
0.0043386486,
-0.011404448,
-0.020949475,
0.019530807,
-0.0069762715,
0.017588744,
0.031954493,
-0.014916687,
0.02068778,
0.0065527367,
0.02377304,
0.0019437835,
0.0078646615,
0.019007413,
-0.01808459,
-0.00007957417,
-0.0047243065,
0.010474738,
0.0034244335,
0.021018343,
0.00208324,
0.027546976,
-0.006043118,
0.03542541,
0.023593985,
0.010516058,
-0.0148065,
-0.008718618,
0.009056068,
-0.026307363,
-0.008353621,
0.018621756,
-0.013009059,
-0.01922779,
0.010805301,
-0.01370462,
0.017698932,
-0.008463808,
-0.019021187,
0.0048379377,
-0.017561197,
0.00085309544,
-0.009173143,
-0.02740924,
-0.010922376,
0.0031902841,
0.047408346,
0.021390228,
0.011617937,
-0.021665696,
0.012237744,
0.036141634,
0.008877013,
-0.017547423,
0.022120222,
-0.0018835245,
-0.0010424809,
0.018814584,
0.0028545554,
0.0050789737,
-0.008436262,
0.029309982,
0.0061774096,
0.00125597,
-0.01425556,
0.08936239,
0.023511345,
0.0015753427,
-0.002308781,
-0.033497125,
0.013477358,
0.01603234,
0.012540761,
-0.019337978,
-0.02950281,
0.00048164165,
-0.0012275621,
0.0033366275,
-0.03225751,
0.02578397,
0.009014748,
0.0013902615,
0.040769525,
-0.02041231,
-0.004311102,
0.03451636,
-0.016238943,
0.009861818,
-0.0035156829,
-0.02262984,
-0.008780599,
0.01575687,
0.013856129,
0.031844303,
-0.02906206,
0.017657612,
-0.003997755,
-0.01772648,
-0.009765403,
0.0011483646,
0.0067421226,
-0.014379522,
0.0054577445,
0.041788764,
0.01907628,
0.0144070685,
0.0028115131,
-0.021514188,
-0.0013894006,
-0.02030212,
-0.0040046414,
-0.009007861,
-0.011411335,
-0.0040321886
] |
CONTEXT Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied for women without vertebral fractures. OBJECTIVE To test the hypothesis that 4 years of alendronate would decrease the risk of clinical and vertebral fractures in women who have low bone mineral density (BMD) but no vertebral fractures. DESIGN Randomized, blinded, placebo-controlled trial. SETTING Eleven community-based clinical research centers. SUBJECTS Women aged 54 to 81 years with a femoral neck BMD of 0.68 g/cm2 or less ( | [
-0.0005471179,
-0.030084519,
0.009330922,
-0.023986306,
-0.0036326991,
0.02600593,
-0.03658928,
-0.026123958,
-0.010216147,
0.0029392731,
0.01817661,
0.022635518,
0.0063801734,
0.0032310693,
-0.0075473585,
0.013022636,
0.039999034,
0.0071801543,
0.013691472,
-0.003449097,
-0.0051539736,
0.0066752485,
0.001504062,
-0.008970275,
0.010294833,
-0.012130855,
0.025546923,
-0.022281429,
0.0049146353,
-0.014557025,
0.025992814,
0.019356908,
-0.003008124,
-0.030084519,
-0.0070096664,
0.02317321,
-0.001501603,
-0.017993007,
0.0072719553,
-0.00054015085,
0.0009106337,
-0.014714398,
0.0025425614,
0.000492611,
0.024510883,
-0.0049572573,
0.019842142,
0.010452206,
-0.01053745,
-0.011435789,
-0.0025261685,
0.022071598,
-0.018111037,
0.050674185,
-0.0010155492,
-0.011868565,
0.014281622,
0.017599575,
0.012609531,
-0.022058483,
-0.01634059,
-0.0054916707,
-0.020471636,
0.005645765,
-0.041861285,
-0.011068584,
-0.009671898,
-0.009940743,
-0.0006827704,
0.007842434,
0.024274822,
0.029481255,
-0.0015278319,
-0.0030097633,
0.01994706,
-0.017730718,
0.009678454,
-0.0004092114,
0.0064818105,
-0.008845688,
0.029953374,
0.00036740914,
-0.014491453,
0.02982223,
0.010511221,
0.026176415,
-0.005235939,
-0.0075735874,
-0.018937247,
-0.008176851,
-0.003481883,
0.01676025,
0.019933945,
0.032182828,
-0.030058289,
0.016655335,
0.015894698,
0.022360114,
-0.01933068,
0.001404884,
-0.01838644,
-0.0050457795,
-0.012825919,
-0.0036622065,
-0.026556734,
0.00997353,
-0.021586364,
-0.008944046,
0.038084324,
-0.009107976,
-0.033022154,
0.046451338,
0.000360647,
-0.007475229,
-0.011743979,
-0.025678068,
-0.009094862,
-0.010334176,
0.021809308,
0.0111275995,
-0.000492611,
-0.009953857,
0.008432583,
-0.013088208,
0.024878087,
-0.0008630939,
0.0032900844,
-0.007875219,
-0.00079260377,
0.0028376363,
-0.008655529,
0.015422578,
0.013481641,
-0.007842434,
-0.03260249,
0.013402955,
-0.011383331,
-0.034123763,
-0.018950362,
-0.049415197,
0.005812974,
0.016353702,
-0.028379641,
-0.015684867,
-0.023278126,
0.010976784,
0.004363829,
0.001970444,
-0.023605987,
-0.020733925,
-0.027592776,
-0.025468236,
0.023015836,
-0.012478387,
-0.0041408837,
-0.028064895,
-0.004606446,
0.020615894,
-0.026963282,
-0.025323978,
-0.017638918,
-0.016852051,
0.0031523828,
-0.0107276095,
-0.011521033,
0.016563535,
0.0008606349,
-0.026556734,
0.0022950266,
-0.0055015064,
0.007350642,
0.038110554,
-0.0272518,
0.0062129647,
-0.0042556347,
0.011973481,
-0.009816156,
-0.017311057,
-0.00950141,
-0.022071598,
-0.027278028,
-0.017953664,
0.046320193,
-0.0076588313,
-0.029796,
0.02704197,
0.015068488,
0.0061768997,
-0.03121236,
-0.024392853,
0.0019999517,
0.010425977,
-0.011980038,
-0.013520985,
-0.6324306,
-0.028615702,
0.016156986,
0.004767098,
0.03032058,
0.013717701,
0.012629203,
0.0055015064,
-0.02355353,
0.012661989,
-0.003222873,
0.032418888,
-0.0065932833,
-0.03184185,
-0.011088257,
-0.009442395,
0.008989947,
-0.009803042,
0.042464547,
-0.009527639,
-0.02458957,
0.028327184,
-0.015684867,
0.0139013035,
0.031763166,
0.0077440753,
-0.0025982978,
-0.0131996805,
0.0030228777,
0.024274822,
-0.0053474116,
0.024550226,
0.016353702,
0.036641736,
0.036667965,
-0.0127144465,
-0.017455315,
-0.002583544,
0.002878619,
0.020235576,
-0.034359824,
-0.011317759,
0.006970323,
-0.010321062,
-0.035592582,
0.0041048187,
0.005858875,
-0.009507967,
0.014714398,
-0.0020310984,
0.023724016,
0.0048293914,
0.003986789,
0.003573684,
0.0078096474,
-0.004035968,
0.025258405,
-0.008471927,
-0.0042326846,
0.0105702365,
0.005311347,
0.002406499,
0.00012274293,
-0.026766567,
-0.017835634,
-0.0054654414,
0.0022130613,
0.02772392,
0.0065670544,
-0.005639208,
0.027592776,
0.033441816,
-0.0016753693,
-0.02169128,
0.058175642,
0.009422723,
0.019160192,
0.015186518,
-0.031081216,
0.012478387,
0.00096882903,
0.016511077,
-0.026832137,
0.0011450542,
0.029271424,
-0.01310788,
-0.016576648,
0.008085051,
0.0055900286,
-0.0049638143,
0.029009135,
0.017402858,
-0.0099014,
-0.049284056,
0.011730864,
0.019251993,
0.029979603,
0.0033277883,
0.017219257,
-0.02166505,
-0.021061786,
0.016681563,
0.0071801543,
-0.0035179476,
-0.0016835659,
-0.0056588794,
-0.02793375,
0.01897659,
0.042648148,
-0.018570043,
0.025822327,
-0.007888334,
-0.022124056,
-0.0087407725,
-0.004681854,
-0.025796097,
0.003767122,
0.011448904,
-0.009776813,
-0.008924374,
0.0136259,
0.0120718395,
0.015422578,
0.02015689,
-0.00041146547,
0.008085051,
0.009914515,
0.028379641,
-0.02305518,
-0.025822327,
0.004983486,
0.028038666,
0.032261513,
-0.0010458763,
0.035225376,
0.009527639,
0.01826841,
-0.018255297,
0.017573345,
-0.028038666,
0.002180275,
-0.0056523224,
-0.0057015014,
-0.018543813,
-0.008524384,
-0.018714301,
-0.025586266,
0.0335205,
-0.029297652,
0.008248981,
-0.017966779,
-0.02704197,
-0.022268314,
0.04047115,
0.0003133121,
-0.009953857,
0.0020474915,
-0.034412283,
-0.022897808,
-0.001105711,
0.017402858,
-0.008504712,
-0.023592873,
-0.006193293,
0.0139144175,
-0.025704296,
0.0052851182,
0.01287182,
0.0076653883,
-0.020327378,
-0.021966683,
-0.02701574,
-0.0069572087,
0.015186518,
-0.028353414,
0.011153828,
-0.011468575,
0.0005659699,
0.017166799,
-0.00070121256,
-0.0055867503,
-0.0067867213,
-0.011757093,
-0.0010557122,
0.02633379,
0.009153877,
0.0069506518,
0.01643239,
0.0009360429,
-0.007350642,
-0.010806296,
0.020681467,
-0.02281912,
0.01655042,
-0.00023585495,
-0.050621726,
0.014150478,
-0.0007430148,
0.004531038,
0.017796291,
0.0386089,
-0.013993104,
0.036038473,
0.0015868469,
0.02795998,
-0.011704635,
0.0014737349,
0.012143969,
0.06100836,
-0.013796388,
-0.021704393,
-0.008360454,
0.011180057,
-0.010032544,
-0.02816981,
-0.008347339,
-0.007986692,
0.00459661,
0.005731009,
-0.0049375854,
-0.009206335,
0.002786818,
0.031159902,
0.022845348,
-0.005167088,
0.014635712,
0.0060883774,
-0.004658904,
0.022058483,
-0.027855065,
-0.0028556685,
0.01676025,
-0.00605887,
0.006773607,
0.0022819121,
0.009527639,
-0.0005012174,
-0.0059801834,
-0.013599671,
-0.00097538624,
0.018727416,
0.026648536,
0.027409174,
0.023487957,
0.027409174,
-0.0078096474,
0.02003886,
0.012130855,
0.015645523,
0.038058095,
0.020301148,
-0.009586654,
-0.0211667,
-0.00923912,
0.011488247,
-0.01386196,
-0.014622597,
0.01619633,
0.030084519,
0.037166316,
0.055972416,
0.053061012,
0.0009040765,
0.011783321,
0.027592776,
0.005832646,
0.0045605456,
0.023278126,
0.0011048913,
-0.023684673,
-0.0143865375,
-0.033809017,
0.011016127,
-0.029402567,
0.0012114461,
0.0070293383,
0.009285022,
0.029035363,
0.028537014,
0.022569947,
-0.027697692,
-0.025428893,
0.010871869,
0.03498932,
-0.007475229,
0.0025868227,
-0.0123275705,
0.0063080443,
0.0018360212,
0.010045659,
0.01018336,
-0.0042097345,
-0.020170003,
0.006491646,
-0.016065186,
0.00014374653,
0.020458521,
-0.00072621193,
0.010340733,
-0.008773559,
-0.005098237,
-0.0019015934,
0.003024517,
-0.020458521,
0.03171071,
-0.009980086,
0.008780115,
-0.029874688,
-0.010032544,
-0.008806344,
-0.005714616,
0.006032641,
0.0058096955,
-0.016445505,
0.022268314,
0.007534244,
-0.02668788,
0.007232612,
0.031054987,
-0.013704587,
0.014766856,
-0.012983292,
-0.0087211,
-0.0025474795,
0.030792698,
-0.0075735874,
-0.005855596,
0.013796388,
0.0035671268,
0.03774335,
0.017193027,
0.0056785513,
-0.0041671125,
0.022294544,
0.0063506663,
-0.00266387,
0.0026884596,
0.0047802124,
0.01006533,
0.01992083,
-0.00080735754,
-0.018714301,
0.014268507,
-0.01820284,
0.0010073527,
0.00021392925,
0.04217603,
0.02246503,
0.023199439,
-0.009534196,
0.004816277,
0.01687828,
0.0012622646,
-0.001671271,
-0.009993201,
0.0030573031,
0.017507773,
0.028327184,
0.00327697,
-0.021717507,
-0.0060195266,
-0.0067867213,
0.00037949902,
-0.005639208,
0.011134157,
0.015671752,
0.016393047,
-0.0004934307,
0.018333983,
-0.011639063,
0.021009328,
0.0155012645,
0.026674764,
-0.0020409343,
0.0258879,
0.00544577,
-0.017009424,
-0.025428893,
0.009678454,
0.0032868057,
-0.0041507194,
-0.010347291,
-0.039710514,
0.010439092,
-0.018688073,
-0.012425929,
0.020340491,
-0.0074555576,
-0.03142219,
-0.02426171,
-0.04747426,
0.026163302,
0.015947156,
0.014399651,
-0.03123859,
0.0017671704,
-0.013875075,
0.013134109,
0.028825533,
0.018215952,
0.02201914,
-0.0006622791,
-0.0234355,
0.01525209,
-0.014648826,
0.011619391,
-0.017193027,
-0.019855257,
-0.016078299,
0.019081505,
0.010865311,
-0.0011770207,
-0.020786382,
-0.004511366,
0.023973191,
-0.0020491309,
0.04028755,
-0.010989898,
-0.015711095,
-0.021494562,
0.01968477,
0.0120849535,
-0.0017212698,
-0.017822519,
0.008360454,
-0.010071888,
-0.01001943,
-0.035959788,
-0.015737325,
0.011062028,
-0.010144017,
0.020314263,
0.008734215,
-0.018989705,
-0.007206383,
-0.013717701,
-0.018766759,
-0.012006267,
0.007206383,
0.015278319,
-0.0074883434,
0.025992814,
0.009350593,
0.018425783,
0.022425687,
-0.00019282321,
0.044326797,
0.0051998743,
-0.010740723,
0.018373325,
-0.006517875,
-0.0034294252,
-0.032471348,
0.0054162624,
0.0054064267,
0.029927146,
0.0005430197,
-0.015868468,
-0.039238397,
0.0014393094,
-0.0057342877,
-0.0068588504,
-0.008458812,
-0.0021065064,
-0.002722885,
-0.0018655286,
-0.027540317,
-0.030818926,
0.023356812,
-0.02211094,
-0.012898048,
-0.0047375904,
-0.019658541,
0.006337552,
-0.033441816,
-0.010117788,
-0.01897659,
-0.007586702,
-0.00058195315,
-0.017993007,
0.0148586575,
-0.03142219,
0.024078107,
-0.006419517,
0.039946575,
-0.026910825,
-0.02958617,
0.044667773,
-0.004226127,
-0.0018852003,
-0.016275017,
0.0073047415,
-0.014622597,
0.0433301,
0.011107928,
0.0013663603,
0.006367059,
-0.012386586,
-0.0010098116,
0.005144138,
-0.008989947,
-0.034412283,
-0.031081216,
-0.033572957,
-0.019697884,
-0.003573684,
-0.007114582,
-0.042438317,
-0.015002916,
0.008235866,
-0.004272028,
0.018543813,
0.007540801,
-0.023789588,
0.010334176,
-0.013809502,
-0.023160096,
-0.0020065089,
-0.018097922,
-0.0055474066,
-0.015278319,
0.0023540414,
-0.01188168,
0.008452254,
-0.008432583,
0.016379932,
0.009363708,
-0.009324364,
-0.014163592,
0.015068488,
-0.008045707,
0.011107928,
-0.021258503,
-0.034097537,
-0.0155012645,
-0.007881776,
0.0077571897,
-0.0049047996,
-0.0075473585,
0.024969889,
0.009114534,
0.03984166,
-0.013455412,
-0.02072081,
0.004032689,
-0.027199343,
0.015829125,
-0.009763698,
0.0078096474,
0.0036359776,
-0.014570139,
-0.022097826,
0.010799739,
0.0139013035,
-0.025428893,
0.016445505,
0.03661551,
-0.021678165,
0.0067342636,
-0.009671898,
0.019579854,
-0.014976687,
-0.021809308,
0.019815914,
0.030399265,
0.0008151442,
-0.0044589085,
0.0061113276,
-0.011193172,
0.013547214,
-0.004688411,
-0.01737663,
0.0017573346,
-0.008989947,
-0.0032310693,
0.015081602,
-0.018740531,
0.013586557,
0.004032689,
-0.011206286,
0.007901448,
-0.015173404,
-0.00815718,
0.02911405,
-0.012734118,
0.041153103,
-0.012052167,
-0.026700994,
0.0036425348,
0.011304645,
-0.008301439,
-0.015212747,
-0.048339814,
0.030556638,
-0.003406475,
-0.00059916585,
0.020458521,
0.020668352,
0.0002319616,
0.0038622017,
-0.01145546,
0.0129570635,
-0.013547214,
0.0040917043,
0.020432293,
0.017179912,
-0.027461631,
-0.0094555095,
-0.020851955,
0.016996311,
0.0024720714,
-0.01065548,
0.004268749,
-0.029743543,
-0.022504374,
-0.0022917478,
0.0024819071,
0.030136976,
0.0027491138,
-0.009521081,
0.016970081,
-0.0030654997,
-0.009094862,
0.008530941,
0.029979603,
0.006989995,
-0.044903833,
-0.0035605696,
-0.021612592,
-0.013835731,
-0.0068916366,
-0.0026064944,
-0.004462187,
-0.0034786044,
-0.01815038,
0.011776765,
0.013291482,
-0.04031378,
0.030477952,
-0.0034622115,
0.035986014,
-0.0025966584,
-0.02866816,
0.0029523876,
0.013993104,
0.008340782,
-0.0023458449,
-0.020825725,
0.008989947,
-0.0031786116,
0.0002711,
0.0007913743,
0.009442395,
0.012616089,
-0.0021950288,
0.00546872,
0.007357199,
-0.033389356,
-0.014032448,
-0.009986644,
-0.004698247,
0.04047115,
-0.01619633,
-0.021769965,
0.017953664,
-0.024838744,
0.005947397,
0.016996311,
0.012058725,
-0.0065014823,
-0.005570357,
-0.0058457605,
-0.027802607,
-0.022228971,
0.015802896,
0.047893923,
0.009357151,
0.007101468,
0.025533808,
-0.023710903,
-0.020851955,
-0.0036622065,
-0.01298985,
0.0010212868,
0.01723237,
0.020694582,
0.024983002,
0.028484557,
0.007934234,
-0.00021802752,
-0.018688073,
-0.018124152,
0.004137605,
-0.02293715,
0.029140279,
0.020642124,
-0.056444537,
0.008780115,
0.023579758,
-0.019409366,
-0.009580096,
0.017389743,
0.0000151123395,
-0.012511173,
-0.016825823,
-0.0075211297,
-0.0086293,
-0.010701381,
0.021088015,
-0.034149993,
0.00030511557,
-0.01223577,
0.013101323,
-0.0074293287,
-0.023973191,
-0.02795998,
-0.025756754,
0.010071888,
-0.028222268,
0.009121091,
0.0043080924,
-0.019370023,
-0.0134422975,
0.032471348,
0.016484847,
0.026766567,
0.0045408737,
-0.01129153,
-0.026556734,
-0.008858802,
-0.0010311226,
-0.011173501,
-0.0015475035,
-0.0009048962,
-0.016209444,
0.0013261974,
-0.0009516163,
-0.019317565,
0.01077351,
-0.0035441767,
-0.018845446,
-0.006904751,
0.030189434,
0.0103276195,
0.008681757,
-0.00079178414,
-0.00629493,
-0.008288324,
0.0036195847,
-0.029271424,
0.006845736,
-0.015225861,
-0.018543813,
0.028537014,
-0.01909462,
-0.010222703,
0.031500876,
-0.042936668,
-0.0027359994,
0.03533029,
0.18570043,
0.0043474357,
-0.006334273,
0.011980038,
-0.01749466,
0.033913933,
0.010334176,
-0.0015909452,
-0.02704197,
0.021402761,
0.03268118,
0.005101516,
0.0012122658,
0.0006044936,
0.01817661,
-0.017402858,
0.002055688,
-0.008832573,
0.0009786648,
-0.014452109,
-0.007901448,
0.009593211,
-0.008786673,
0.0030146812,
0.037245,
0.011573491,
-0.022687975,
-0.0017081554,
0.028012438,
0.025009232,
0.0031999226,
-0.0011024324,
0.0076588313,
-0.00039261347,
-0.011816108,
-0.022386344,
-0.0022606011,
-0.0049343067,
-0.021678165,
0.009330922,
-0.00879323,
-0.014740627,
-0.02175685,
-0.003921217,
-0.009048961,
0.010117788,
0.009842385,
-0.01569798,
-0.030346807,
0.005229382,
-0.024838744,
0.010530893,
0.026884595,
0.0011573491,
0.0070424527,
0.00026085434,
0.021350304,
-0.00025306764,
-0.017809406,
-0.02072081,
0.008826016,
-0.0066096764,
-0.008039149,
0.011160386,
-0.029455025,
0.013258696,
0.0009294857,
-0.023671558,
0.015383234,
0.013494756,
0.022989608,
0.015225861,
-0.008871917,
0.026910825,
-0.013783273,
-0.011225958,
0.021914225,
0.018766759,
0.022137169,
-0.017074997,
-0.015330777,
-0.0069572087,
0.011068584,
0.0044785803,
-0.019658541,
0.0005122827,
-0.013311153,
-0.0041474407,
0.0035343408,
0.00036413054,
0.0009762059,
-0.012209541,
-0.006989995,
-0.0034949975,
0.030373037,
-0.006140835,
-0.003950724,
-0.0036359776,
-0.02468137,
-0.019015934,
-0.034858175,
0.064680405,
-0.014412766,
0.024078107,
-0.0049539786,
0.014452109,
-0.026714109,
0.031107444,
-0.025520694,
-0.002954027,
0.020392949,
-0.026635421,
0.01275379,
-0.028720617,
0.0022179792,
0.001813071,
0.004531038,
-0.047815237,
0.014006219,
-0.034045078,
0.0013499673,
-0.018858561,
0.011462018,
0.026596079,
0.00023749426,
-0.013599671,
0.0011540705,
-0.016904509,
-0.0015909452,
-0.025678068,
0.008616185,
-0.020222463,
-0.014438995,
0.020497864,
-0.007114582,
0.039736744,
-0.001199971,
0.01136366,
-0.012498058,
0.018858561,
0.0078096474,
-0.0016778283,
0.042490777,
0.004557267,
0.0081834085,
-0.014360309,
0.0072785127,
-0.024156792,
-0.010576793,
-0.00855717,
-0.014570139,
0.004009739,
0.0021081457,
0.0016901231,
0.035461437,
0.007842434,
-0.032418888,
-0.044064507,
-0.012721004,
0.025442008,
-0.02935011,
-0.0080260355,
0.046241503,
0.001749138,
0.021651935,
0.0145439105,
-0.16377309,
0.018438898,
0.013966875,
-0.040208865,
0.007842434,
0.002362238,
0.03213037,
-0.0036720424,
-0.032104142,
-0.01723237,
0.012701333,
0.020694582,
-0.014504568,
-0.012727561,
0.0034622115,
-0.004357272,
0.013317711,
0.00815718,
0.026700994,
0.02187488,
0.008091608,
-0.02816981,
0.009291579,
-0.023658445,
0.005386755,
-0.0025802655,
0.019907715,
0.02260929,
0.016248787,
0.023894504,
-0.00855717,
-0.014675055,
0.019015934,
-0.010780067,
-0.010432535,
-0.008340782,
-0.011022684,
0.0044851373,
0.003439261,
0.016275017,
0.017783176,
0.021271616,
-0.0006344109,
-0.005426098,
0.012839034,
0.023422385,
0.0053244615,
-0.03674665,
0.01676025,
-0.012465272,
0.0052556107,
-0.026386248,
0.022124056,
0.024602683,
0.0005184301,
0.02701574,
-0.018360212,
0.024602683,
-0.0028245219,
-0.014635712,
-0.025901012,
-0.0051703667,
0.010530893,
0.0023179767,
-0.013639014,
0.0032195942,
-0.01770449,
-0.009429281,
-0.0067670494,
0.00919322,
-0.042490777,
-0.0058457605,
0.0016704514,
0.012950506,
0.013940646,
0.029848458,
0.002572069,
0.005993298,
0.011901352,
-0.0015179961,
0.0041572764,
-0.015317663,
-0.026045272,
-0.013258696,
-0.0069506518,
0.0118423365,
0.021455219,
0.015763553,
0.0009557146,
-0.0077244034,
0.014307851,
-0.051802024,
0.005832646,
-0.006629348,
0.011193172,
0.0086752,
-0.0006139196,
-0.008570285,
-0.013101323,
-0.022347001,
-0.0071998257,
-0.01442588,
-0.039736744,
0.025730526,
0.027068198,
-0.015802896,
-0.014412766,
-0.001770449,
-0.0045703813,
-0.045349725,
0.005291675,
0.019147078,
0.02175685,
0.031500876,
-0.005494949,
0.009160434,
0.004206456,
-0.017127454,
-0.013330826,
-0.009337479,
0.043461245,
0.015278319,
-0.0034589327,
0.008885031,
-0.007108025,
-0.01992083,
-0.109531775,
-0.0066129547,
-0.014229164,
0.015829125,
-0.014557025,
0.0042326846,
0.0023638774,
0.021284731,
-0.00509168,
0.02281912,
-0.025284635,
-0.0069572087,
-0.021678165,
0.0038490873,
0.02795998,
-0.020524094,
0.012176755,
-0.0210749,
-0.010675152,
0.036510594,
-0.00518676,
0.0022491259,
0.01468817,
-0.025140375,
-0.009553867,
-0.013809502,
-0.012917721,
0.019855257,
0.009344037,
0.019514283,
0.0015638967,
-0.006963766,
0.015776668,
0.004842506,
-0.021389646,
-0.040182635,
-0.02157325,
-0.010793182,
0.017363515,
-0.025966585,
0.016497962,
-0.003095007,
0.017415972,
0.0065211537,
0.024143679,
-0.02423548,
-0.038976107,
-0.009645669,
0.007173597,
0.012825919,
-0.014583254,
-0.024891201,
0.00055654394,
0.0017720883,
0.027828835,
0.008373568,
-0.005426098,
0.00681295,
-0.012465272,
-0.0086686425,
-0.024746943,
0.009219449,
-0.022176513,
0.0020737203,
0.010957113,
-0.009363708,
-0.011239072,
-0.027094427,
-0.013875075,
-0.0016368456,
-0.014530797,
-0.0024819071,
-0.0070883534,
-0.009252235,
-0.018517585,
0.022215856,
-0.019750342,
-0.01673402,
0.0032753306,
-0.0029212409,
-0.025914127,
-0.009606325,
0.017219257,
-0.013704587,
0.008491598,
0.020104432,
0.012019382,
0.013396397,
0.035986014,
-0.020537209,
-0.012261999,
0.017717604,
-0.016904509,
-0.008616185,
-0.01619633,
0.016917624,
-0.0070490097,
-0.03800564,
0.012366914,
0.01850447,
-0.03286478,
-0.018674958,
-0.061323106,
0.034071308,
0.041126873,
-0.009160434,
-0.0067408206,
-0.0058523174,
0.033913933,
0.004511366,
-0.017245485,
0.018032352,
-0.018740531,
-0.0022786334,
0.00034322942,
0.00000831819,
-0.019724114,
0.005471999,
0.044694003,
0.010957113,
0.044116966,
0.03818924,
-0.0055637998,
-0.00068809814,
-0.008360454,
0.026268218,
-0.012747233,
-0.0066326265,
-0.00907519,
0.0037769577,
-0.0052818395,
-0.014491453,
0.015763553,
-0.029297652,
-0.013888189,
-0.002572069,
-0.023973191,
-0.020602781,
-0.006780164,
0.015763553,
0.015855355,
0.015094717,
-0.0070883534,
-0.018766759,
0.039946575,
0.0031064823,
0.0033031988,
0.000043236658,
-0.02373713,
0.0015942238,
0.00078112865,
-0.018714301,
-0.009003061,
-0.010950555,
0.01982903,
-0.023448613,
-0.022530602,
0.005908054,
-0.004917914,
0.004029411,
-0.02937634,
-0.008189966,
0.01942248,
0.018360212,
-0.037245,
-0.010209589,
0.009344037,
-0.013068536,
-0.0020442128,
0.007875219,
-0.0035638483,
-0.008491598,
-0.0040228534,
-0.006645741,
0.01643239,
0.0048949635,
-0.009285022,
0.014871771,
-0.012058725,
0.0027917358,
-0.011875123,
0.008937489,
-0.002340927,
-0.017796291,
-0.019488053,
0.033415586,
-0.0129570635,
0.014019333,
-0.011180057,
0.017953664,
0.013783273,
0.0053015114,
-0.0056490437,
0.0047539836,
-0.0042589135,
0.011534147,
0.009042405,
0.008117837,
0.012393143,
-0.032917235,
-0.00069465535,
0.0022458474,
-0.0007971119,
0.017520888,
0.0045408737,
-0.019356908,
-0.017966779,
0.014307851,
-0.03312707,
-0.029927146,
-0.005403148,
0.016681563,
0.043067813,
0.008576842,
0.0063080443,
0.011068584,
0.0041736695,
0.007022781,
0.008130951,
-0.0209831,
-0.006301487,
0.01756023,
0.010976784,
0.029900916,
0.011101371,
0.011094813,
0.03213037,
0.005471999,
0.04007772,
-0.032969695,
0.0068326215,
-0.0043408787,
0.019501168,
-0.014753741,
-0.03142219,
0.008944046,
0.0010540729,
-0.022779778,
-0.025074804,
0.02142899,
-0.014648826,
0.08367011,
0.0111275995,
-0.016563535,
0.0073047415,
-0.006452303,
0.0021458499,
-0.020104432,
0.024287937,
0.008340782,
-0.016786478,
0.008786673,
-0.0076129306,
0.0023442055,
-0.0098554995,
-0.013022636,
0.010983341,
0.012668546,
0.011750535,
-0.014478339,
0.0021753572,
0.026740337,
-0.009068633,
0.0057211732,
0.010432535,
-0.026386248,
-0.0072653983,
0.029192736,
0.0063146013,
-0.013652129,
-0.027409174,
-0.009888286,
0.024642028,
-0.02793375,
-0.013337382,
0.02772392,
-0.013691472,
-0.0032294302,
-0.016471732,
-0.011048913,
-0.016786478,
-0.014583254,
0.029455025,
-0.01216364,
-0.021088015,
-0.023094524,
-0.023212554,
-0.0044425153,
-0.014740627,
0.001482751
] |
Synaptic vesicle recycling involves AP-2/clathrin-mediated endocytosis, but it is not known whether the endosomal pathway is also required. Mice deficient in the tissue-specific AP-1-sigma1B complex have impaired synaptic vesicle recycling in hippocampal synapses. The ubiquitously expressed AP-1-sigma1A complex mediates protein sorting between the trans-Golgi network and early endosomes. Vertebrates express three sigma1 subunit isoforms: A, B and C. The expressions of sigma1A and sigma1B are highest in the brain. Synaptic vesicle re | [
-0.004973421,
0.0038282915,
-0.004583875,
-0.016307179,
-0.02720102,
0.029874107,
-0.019289216,
0.015151975,
0.0039693336,
-0.021559326,
0.03707398,
-0.0004344607,
0.00096127053,
0.01425199,
-0.004315223,
-0.017905658,
0.025333887,
0.017045971,
0.000994852,
0.012700525,
-0.027993541,
0.01677732,
0.020981723,
-0.03903514,
0.011404279,
0.012028894,
0.013781849,
-0.030223353,
-0.010490862,
-0.014332586,
0.0048122294,
0.01120279,
-0.008375227,
-0.00401299,
-0.008959546,
-0.0111624915,
0.009154318,
-0.014117665,
0.0071327114,
-0.011592335,
0.020753369,
0.011760243,
-0.02162649,
0.02059218,
0.008596865,
0.0037409796,
-0.02725475,
-0.0036603839,
-0.0022717887,
0.02044442,
0.015057947,
0.010410266,
-0.03213078,
0.008415525,
-0.030008432,
-0.0085229855,
-0.012673659,
0.013499765,
0.00978565,
-0.0024951058,
-0.0019040713,
-0.000994852,
-0.021156348,
-0.0011610806,
0.005386473,
0.019275783,
0.02777862,
-0.0010628547,
0.010269224,
-0.0051245377,
0.03411881,
0.015702711,
-0.017113134,
-0.008146873,
0.027886081,
-0.013721403,
-0.017368354,
-0.0052958033,
-0.01574301,
0.013278127,
-0.006984953,
-0.014426614,
-0.017475815,
0.023816003,
0.020874264,
0.0103968335,
0.006252876,
0.01579674,
0.021532461,
0.016750455,
0.012922163,
0.018026551,
0.015447492,
0.008563284,
-0.009765501,
0.02178768,
0.001606875,
0.008825219,
-0.018080281,
-0.012418441,
-0.038067993,
0.016025094,
-0.0022046256,
-0.019745924,
-0.004644322,
-0.008482688,
0.00036603838,
-0.007428229,
0.024904044,
-0.001038508,
-0.019947413,
0.022029467,
-0.011518456,
-0.025347319,
0.02292945,
0.0024128312,
0.033312853,
-0.0037577704,
-0.015165407,
-0.020430988,
0.008120008,
0.01045728,
0.013204248,
-0.011135627,
0.029954702,
0.044327587,
-0.015138542,
0.0061756386,
-0.018214608,
0.005833107,
0.010269224,
0.026959231,
0.008697609,
0.027939811,
-0.017113134,
-0.010114749,
0.015514655,
0.02168022,
0.010504294,
-0.03769188,
-0.014977351,
0.029954702,
-0.020041442,
0.0071797254,
-0.019960847,
0.031351693,
0.033877023,
-0.0004911295,
0.0025538735,
0.008287915,
-0.004086869,
-0.013587076,
-0.0055107246,
-0.015138542,
0.011639349,
0.013701254,
-0.02091456,
0.0031415496,
-0.0116057675,
-0.028584577,
-0.029471127,
-0.013163949,
0.0010997943,
-0.0066457796,
0.02720102,
0.0250921,
0.005470427,
-0.0054402035,
0.006897641,
-0.021599624,
-0.0053193104,
-0.017717602,
-0.013822147,
0.027483104,
-0.03527401,
0.0074013635,
0.03438746,
0.018805642,
-0.04486489,
-0.037369497,
-0.014359451,
0.0030307306,
0.020404123,
-0.0012970855,
0.0018268338,
0.0034068436,
0.017959388,
-0.009993856,
0.009080439,
-0.012391575,
0.009033425,
-0.011968448,
-0.010437132,
-0.045885768,
-0.62241304,
-0.04413953,
0.019168323,
-0.01605196,
0.0020652625,
0.04889467,
0.0071595768,
0.0052722963,
-0.0143191535,
0.016951943,
-0.01993398,
0.025347319,
-0.0026680506,
-0.015138542,
-0.020484718,
-0.039169468,
0.008630446,
-0.014010203,
0.03350091,
0.019195188,
-0.0477932,
-0.0069983853,
-0.014950486,
0.026636848,
0.02679804,
0.006498021,
0.029095015,
-0.029954702,
-0.029202476,
0.021666786,
-0.019705627,
0.034924764,
-0.019383244,
-0.007253605,
0.050211065,
0.031271096,
-0.017986253,
0.03712771,
0.031324826,
0.043441035,
-0.016119123,
-0.007394647,
-0.0047182012,
0.010739365,
-0.027644293,
0.0070453994,
0.023278698,
0.01107518,
0.0036939655,
-0.028718902,
0.03315166,
0.0008873913,
-0.026865203,
0.020108605,
0.00593721,
0.009698339,
0.027805485,
-0.018268337,
0.011800541,
0.00010840529,
0.012754255,
0.011659498,
0.0011535246,
-0.031056175,
-0.015514655,
0.006407351,
-0.0022230956,
-0.027120423,
0.022338416,
0.007864788,
0.011303535,
-0.008818503,
0.011733377,
0.014668401,
0.0098796785,
0.016669858,
0.009819232,
-0.0034236345,
-0.008865517,
0.0049902117,
0.018617585,
-0.0022717887,
-0.010470713,
-0.028826363,
0.011478158,
0.020484718,
-0.010490862,
0.025521943,
0.028154733,
0.009375956,
-0.0011325362,
0.0024279428,
-0.0003230121,
-0.04929765,
-0.035354607,
0.026475659,
0.009483417,
0.015823605,
0.00041389203,
-0.020981723,
-0.0049868533,
-0.0033782993,
0.0021105974,
-0.0064711557,
0.016696723,
0.011363981,
-0.022284687,
0.008381943,
0.051097617,
-0.01677732,
-0.004449549,
-0.011343832,
-0.00764315,
-0.008482688,
-0.0195713,
-0.019544436,
0.031324826,
-0.0007564234,
0.00039752104,
-0.024232414,
0.013197531,
-0.026502524,
-0.0023591006,
0.0017529546,
-0.005178268,
0.02391003,
0.0026260735,
-0.019719059,
-0.009107304,
-0.002521971,
-0.0029753214,
-0.008999843,
0.0040264223,
-0.0114580095,
0.033366583,
0.023292132,
0.01192815,
0.0035059091,
0.00091425644,
-0.050721504,
-0.0030743866,
0.007515541,
0.012149788,
-0.033903886,
0.005275654,
-0.011397563,
-0.0065349606,
-0.007878221,
0.0037208307,
-0.006951371,
0.0067163007,
-0.030733792,
-0.004805513,
-0.0065920493,
0.016763886,
-0.018402664,
-0.029041285,
-0.019020565,
-0.015689278,
-0.015219138,
0.008885666,
0.0036570258,
-0.011854271,
0.015608683,
-0.012324412,
-0.026153276,
0.011760243,
-0.011793824,
-0.0013718044,
-0.025830893,
0.011518456,
-0.01016848,
-0.023977194,
0.014735564,
-0.0038484405,
0.015031082,
0.003015619,
0.005131254,
0.0017798197,
-0.0023423098,
0.0019359738,
-0.016925078,
-0.009564012,
-0.0044596237,
0.04319925,
0.012700525,
0.038336646,
0.0067767478,
0.029497994,
0.029202476,
0.004926407,
0.017328056,
0.0049297647,
0.013687821,
-0.009429687,
-0.014520642,
0.0069312225,
0.02220409,
0.004892825,
0.02746967,
0.014816159,
-0.022392146,
0.0012844926,
-0.033259124,
0.030653197,
-0.022257822,
-0.0055476646,
-0.016642993,
0.0021240301,
0.018671317,
0.00991326,
0.0016807542,
0.010793095,
-0.005759228,
-0.00379471,
-0.00263279,
0.0147624295,
0.020713072,
-0.016025094,
-0.009832664,
-0.010242359,
-0.021048887,
0.008603581,
-0.0056987815,
-0.011404279,
0.0238966,
0.0077976254,
0.027429372,
-0.0021307464,
-0.007549122,
0.008308064,
0.004728276,
0.006625631,
0.028154733,
0.015246003,
0.021263808,
0.014413182,
0.011001301,
0.023802571,
0.008287915,
0.017435517,
0.025441347,
0.005957359,
0.00844239,
-0.0009058611,
-0.00044999216,
0.028584577,
0.022271253,
-0.010833393,
0.013049773,
-0.031190502,
0.005584604,
-0.018993698,
0.007387931,
-0.0060614613,
-0.006719659,
-0.002928307,
0.012653511,
0.019974278,
0.03898141,
-0.0152325705,
-0.019987712,
-0.005443562,
0.0018150803,
0.008234185,
0.013190815,
-0.0023423098,
0.0070655486,
0.0022835422,
-0.006585333,
-0.014077366,
-0.0023893241,
-0.016535532,
-0.033742696,
0.027805485,
0.0019023923,
0.00009990497,
-0.0010720895,
0.013049773,
0.0051446864,
-0.02896069,
-0.042500753,
0.011478158,
0.014601238,
-0.0065987655,
-0.0119751645,
-0.025790595,
0.0017697453,
-0.0071864417,
-0.0008072154,
-0.009496849,
0.010114749,
0.00087815634,
-0.0047450666,
-0.025280157,
0.014668401,
0.034817304,
-0.0043252977,
0.0071864417,
-0.0153803285,
0.011672931,
0.008664028,
-0.019705627,
0.016159419,
0.053730406,
0.0050775236,
-0.011686363,
0.0037712029,
-0.010772946,
-0.01859072,
0.003010582,
-0.0025622689,
-0.009631176,
-0.018926537,
0.0114580095,
-0.0042782836,
-0.015890768,
0.011068463,
0.02158619,
0.018241473,
-0.024447335,
-0.021666786,
-0.0062428014,
-0.004352163,
0.0032792338,
0.010806528,
-0.008402092,
0.014937053,
-0.006719659,
0.0050741653,
-0.015366896,
0.0050506582,
0.008059561,
-0.01993398,
-0.015635548,
-0.01848326,
0.0043420885,
0.0033984482,
0.021572758,
0.03712771,
-0.019705627,
-0.0069715204,
0.02452793,
-0.037396364,
0.02163992,
-0.0007921037,
-0.005715572,
0.017113134,
0.0071125627,
-0.010383401,
0.027509969,
0.023977194,
0.024272712,
-0.043655954,
0.014587806,
0.010927421,
0.011135627,
0.014829592,
-0.023533918,
-0.03199646,
0.0070185345,
0.037879936,
-0.0049868533,
0.03618743,
0.014131097,
0.0077103134,
0.019651895,
0.000042213,
-0.0034085226,
-0.0055073667,
0.0038282915,
-0.0015338352,
0.00844239,
-0.010940854,
0.048706613,
-0.0057793767,
-0.010302805,
-0.015071379,
0.0028326,
-0.0071595768,
0.023023479,
-0.009382673,
-0.0023725333,
-0.028342789,
-0.007300619,
0.0017328056,
-0.023332428,
-0.015501223,
-0.0048659598,
-0.03264122,
-0.00089662615,
-0.025615972,
-0.006380486,
-0.015272868,
0.0056584836,
-0.040190343,
-0.01941011,
-0.020874264,
0.020202633,
0.037853073,
0.009738636,
-0.015554952,
0.0023993985,
0.04615442,
-0.025844326,
-0.01554152,
-0.009604311,
-0.02168022,
0.013439318,
0.015890768,
0.016535532,
-0.024353307,
-0.019235486,
-0.01812058,
0.061413854,
-0.015004216,
0.026354764,
-0.0064946627,
-0.002609283,
-0.006101759,
0.041909717,
0.03299047,
0.0027671158,
-0.002343989,
-0.00020799544,
-0.015299734,
-0.011363981,
-0.014265423,
-0.0065349606,
-0.0010855221,
0.0005490576,
-0.007119279,
-0.0038249334,
-0.0036939655,
0.0065316027,
-0.011827406,
-0.008711042,
-0.0010695709,
0.021545893,
0.028074138,
0.0049868533,
0.024595093,
0.03030395,
0.010390118,
0.01817431,
-0.019275783,
0.012707241,
0.0058599724,
-0.017072836,
0.0128885815,
-0.008818503,
-0.012572915,
0.000004197688,
0.008361795,
0.0022818632,
0.032318838,
-0.0016773961,
-0.015165407,
-0.028074138,
-0.011256521,
-0.0058431816,
0.006498021,
0.0012282435,
-0.008496121,
-0.007777476,
0.004043213,
-0.018751912,
-0.0077573275,
-0.007031967,
-0.039357524,
0.0010040869,
0.01657583,
-0.0040801526,
0.00013516555,
0.011410995,
-0.0041607483,
-0.037503824,
-0.024447335,
-0.023466755,
-0.031405423,
0.0047383504,
0.0006254555,
0.031969592,
0.021210078,
0.03433373,
0.030089028,
0.0058196746,
0.014372883,
0.007233456,
-0.0041641067,
-0.0065114535,
0.013022907,
-0.012619929,
0.03207705,
-0.0022012675,
-0.019745924,
0.037557553,
-0.006269667,
0.024353307,
0.025293589,
-0.0023087284,
-0.034414325,
0.012337845,
-0.033474043,
-0.016387774,
0.0006859022,
0.008247618,
-0.013573644,
-0.031271096,
-0.0027133855,
-0.0071998746,
0.021102617,
-0.016737022,
-0.014654969,
0.043441035,
-0.019665329,
0.03495163,
-0.011552038,
-0.0043655955,
-0.0073744985,
-0.0041674646,
-0.0048995414,
0.0083013475,
0.010383401,
0.0027100274,
-0.003257406,
0.009496849,
0.019598166,
0.0010074452,
0.014722131,
-0.0024682404,
-0.017637005,
0.0048592435,
-0.0018453037,
-0.042420156,
-0.021438433,
-0.025427915,
-0.048034985,
0.0094364025,
0.015622116,
-0.013304992,
0.024232414,
-0.008355078,
-0.023104075,
0.040539593,
-0.013795282,
0.031808402,
0.0013348648,
0.022983182,
0.012633362,
0.0046913363,
-0.02571,
-0.022795126,
0.011840838,
0.010772946,
0.022956315,
0.047202162,
0.0018369083,
-0.008825219,
-0.015447492,
0.006857343,
-0.014372883,
-0.040056016,
0.036536675,
-0.004345447,
-0.004442833,
-0.004624173,
-0.0056148274,
-0.019665329,
0.014829592,
-0.0064207837,
0.005329385,
0.005164835,
-0.011599052,
-0.014332586,
0.030008432,
0.0025790595,
0.022902586,
0.018442962,
-0.00009056512,
0.007347633,
-0.02318467,
0.020847397,
-0.008180454,
0.000019479896,
0.021304106,
0.0059304936,
-0.009664757,
-0.00130716,
0.023372727,
-0.0028645024,
-0.015057947,
0.0007883258,
0.035139687,
0.008556567,
-0.0065080957,
0.011034883,
0.0014297325,
0.005608111,
-0.010853542,
-0.00060740544,
-0.011028166,
-0.029605454,
-0.015407194,
0.029336803,
0.019719059,
-0.004734992,
-0.017663872,
-0.012418441,
0.028101003,
-0.039384387,
-0.022284687,
0.018993698,
-0.041479874,
0.005386473,
0.00013967807,
0.014292289,
0.008912532,
0.0002503921,
0.023050344,
-0.014359451,
0.03350091,
-0.03669787,
0.02282199,
0.00016948166,
0.0054536364,
-0.025790595,
0.012593064,
-0.013493048,
-0.01677732,
0.01182069,
-0.024004059,
-0.0232384,
0.022902586,
-0.017341489,
0.034629248,
0.007817774,
-0.0047954386,
0.02716072,
-0.0036435933,
-0.0016824333,
0.0040499293,
-0.0030777447,
-0.0071327114,
-0.033420313,
-0.009510282,
0.0027553623,
-0.01169308,
-0.0073207677,
0.0102490755,
-0.004892825,
0.019759357,
-0.0031146845,
-0.0034656113,
0.0066155563,
-0.025562242,
-0.007743895,
-0.0077170297,
-0.000343161,
-0.0047383504,
-0.009456552,
0.008066277,
-0.0038786638,
-0.03763815,
-0.008482688,
-0.002298654,
0.016495235,
-0.0067163007,
-0.00203336,
0.016817618,
-0.0056215436,
-0.019383244,
-0.024299577,
0.00082148757,
-0.034736708,
0.026717445,
0.016683292,
-0.011518456,
0.005530874,
-0.0034051645,
-0.03153975,
-0.008348362,
-0.010954287,
-0.015971363,
0.005584604,
0.017328056,
-0.024138385,
0.0009419612,
0.011404279,
0.012720673,
-0.01492362,
-0.0009394426,
0.010967719,
0.002192872,
-0.009248346,
0.019893683,
-0.03527401,
-0.02979351,
0.03887395,
-0.0071125627,
-0.009570729,
0.03868589,
-0.016656427,
0.01585047,
0.004244702,
-0.011894569,
0.01045728,
0.01554152,
0.011545321,
-0.0033665458,
-0.013667672,
0.00942297,
-0.0027805485,
-0.02968605,
-0.0070856973,
-0.017475815,
-0.010564741,
-0.004664471,
-0.017059404,
-0.019759357,
0.010913989,
-0.02596522,
0.018228041,
0.030921848,
-0.0059472844,
-0.0025924922,
0.027106991,
-0.02245931,
-0.026059248,
0.008267766,
-0.018765345,
0.0032859503,
-0.0070924135,
-0.004731634,
-0.000032453376,
0.0046510384,
0.016642993,
-0.016078824,
0.006363695,
-0.007173009,
-0.0017479173,
-0.04325298,
0.013197531,
-0.004889467,
-0.023829436,
-0.001585047,
0.012579631,
-0.0023607798,
-0.0040801526,
0.0072670374,
-0.0019242202,
-0.012049044,
0.018725047,
-0.008489404,
-0.023036912,
-0.02823533,
-0.029336803,
0.0019611598,
-0.0071327114,
0.008529702,
0.17408651,
-0.012774404,
0.004909616,
0.0009134169,
-0.012478887,
-0.019799655,
0.02478315,
-0.002545478,
0.0076901643,
0.0109878685,
0.018953402,
0.017596709,
-0.0030928566,
-0.004305149,
0.0074685267,
-0.00746181,
-0.033581503,
-0.011887852,
-0.015192272,
0.006142057,
0.012700525,
0.002164328,
0.030115893,
-0.0058398237,
0.01605196,
-0.0021760815,
-0.037503824,
-0.017180298,
0.007434945,
0.023426456,
-0.034871034,
-0.007428229,
-0.0003309877,
0.019168323,
0.007031967,
0.00029803585,
-0.011538605,
0.003458895,
0.0077976254,
0.02901442,
-0.012807986,
-0.0033984482,
-0.00083869806,
-0.006162206,
-0.030089028,
0.0024598453,
-0.003391732,
-0.028826363,
-0.00978565,
-0.00057130534,
-0.057706457,
0.025642836,
0.004362237,
0.00669951,
0.0039995573,
-0.014010203,
-0.002612641,
0.032909874,
0.000001821731,
0.035999373,
-0.006897641,
0.00887895,
-0.024957774,
0.022378715,
-0.0065719006,
0.0076230015,
-0.01187442,
-0.037396364,
0.045455925,
-0.033312853,
0.016696723,
0.0032389362,
-0.019248918,
-0.011256521,
-0.014184827,
-0.0102490755,
0.019222053,
0.014426614,
0.018859373,
0.014332586,
-0.0014725489,
0.0069782366,
-0.030438276,
-0.006356979,
-0.004617457,
-0.009765501,
0.033474043,
0.0021676861,
-0.013251262,
-0.00433873,
0.0107125,
-0.018684749,
-0.005913703,
-0.020484718,
0.007837923,
-0.01605196,
-0.0033883739,
-0.003818217,
-0.0019712343,
-0.023574216,
-0.016589263,
0.08263736,
0.022163793,
0.026569687,
-0.014963918,
-0.009201332,
0.012539334,
-0.0009856172,
0.004845811,
-0.02498464,
-0.0009621101,
-0.021263808,
-0.011155776,
-0.018993698,
-0.004996928,
0.0073543494,
0.008072994,
-0.013983338,
0.050425988,
0.026354764,
-0.007911802,
-0.021854842,
0.01321768,
0.006679361,
-0.0033615085,
0.011424428,
-0.01632061,
0.018254906,
0.0019678762,
-0.040996302,
0.019033996,
0.020525016,
-0.00025857758,
0.0053931894,
0.0023792495,
-0.0038820219,
-0.0069983853,
-0.008012547,
-0.006252876,
0.009375956,
-0.0038484405,
0.008469256,
0.017878793,
-0.00857,
0.0012786158,
0.0060110893,
0.016226582,
0.012660227,
-0.03830978,
-0.0077506113,
-0.011585619,
-0.0036032954,
0.007811058,
-0.014305721,
0.014574373,
-0.03624116,
-0.013197531,
-0.034736708,
-0.016334044,
-0.0048491694,
-0.026086112,
0.011585619,
0.005984224,
-0.01309007,
-0.010511011,
-0.010725932,
-0.16871348,
0.011055031,
0.0021391418,
-0.006182355,
-0.002859465,
0.015702711,
-0.0013600509,
0.013902742,
-0.010665486,
-0.008240901,
0.01728776,
-0.0016530495,
-0.028853228,
-0.03454865,
-0.00016654328,
-0.0072737536,
-0.027362209,
0.004211121,
0.0056181857,
-0.0022382073,
0.018456394,
-0.05281699,
0.0147624295,
-0.02131754,
0.024568228,
0.0087446235,
0.00020726085,
-0.009255063,
0.0023859658,
-0.016253447,
0.004620815,
-0.0022298119,
0.04827677,
-0.0007639792,
0.023480188,
-0.0026932366,
-0.016347475,
0.0026949157,
0.013231113,
0.026059248,
0.038067993,
0.016508667,
0.012606497,
-0.003972692,
-0.017650438,
0.006387202,
0.01370797,
0.0005654286,
-0.01298261,
-0.009308793,
-0.019396678,
-0.0065316027,
-0.004886109,
0.023762273,
0.0069245063,
0.013405737,
0.019786222,
0.019692194,
-0.014265423,
0.012680376,
-0.009275211,
-0.008543135,
0.058351222,
-0.01801312,
0.009402821,
-0.028772634,
-0.0074886754,
-0.028101003,
-0.030169623,
0.02601895,
-0.0048256624,
-0.009490133,
0.0058398237,
-0.019799655,
0.0047081267,
0.034817304,
-0.00064098695,
0.012754255,
-0.00996699,
-0.01626688,
-0.017784765,
0.011216222,
-0.021922005,
-0.044032067,
0.0002919492,
-0.0066424217,
0.0074886754,
-0.009248346,
0.007945384,
0.012834851,
-0.00916775,
-0.037476957,
0.0061084754,
-0.007347633,
0.04822304,
0.0062192944,
-0.026260735,
-0.0039592595,
-0.010927421,
0.0095572965,
0.006538319,
0.0020451136,
-0.0030324098,
0.0047954386,
0.03865903,
0.0046779034,
-0.003549565,
0.011296818,
0.030787524,
-0.008583432,
0.0010628547,
-0.013170666,
0.001875527,
0.020766802,
-0.02013547,
0.018442962,
0.005577888,
-0.0037712029,
0.0124453055,
-0.029363668,
0.070601754,
-0.011108762,
0.017851928,
0.01832207,
-0.00045377007,
-0.0060413126,
-0.13400364,
-0.017717602,
-0.007394647,
0.024004059,
-0.0072200233,
-0.0042950744,
0.008993126,
0.03444119,
-0.008576716,
0.02699953,
-0.017462382,
-0.0048189457,
0.00005352052,
-0.019531002,
0.00074341055,
-0.0074013635,
0.01169308,
-0.010497578,
-0.018657884,
0.009872962,
0.0014683512,
0.014829592,
0.026462225,
0.010907273,
-0.010833393,
-0.0005528355,
-0.024353307,
0.032748684,
0.00433873,
0.007125995,
0.026421927,
-0.0008177096,
-0.01029609,
0.007965533,
-0.0066390634,
-0.023265267,
0.012989325,
-0.02618014,
0.029551724,
-0.0042547765,
-0.0035462067,
0.00039773094,
0.025790595,
-0.0027906229,
-0.017260892,
-0.007938667,
-0.004362237,
-0.0031835267,
0.007609569,
-0.019866819,
-0.044112664,
-0.026650282,
-0.027456237,
-0.008153589,
0.009819232,
-0.0047685737,
-0.0044999216,
0.02514583,
0.001897355,
-0.010054302,
0.0025790595,
0.014426614,
-0.0047081267,
-0.009611026,
0.020713072,
-0.010114749,
-0.030921848,
-0.029497994,
0.035193417,
-0.007918519,
0.013452751,
0.009799083,
-0.017234027,
0.00068800105,
-0.018254906,
0.007723746,
0.008355078,
-0.010739365,
0.003616728,
-0.009799083,
-0.021102617,
-0.017731033,
0.02699953,
-0.004177539,
-0.007260321,
0.008126724,
0.004734992,
0.0046040243,
0.01218337,
-0.021935439,
-0.0072401725,
0.020122038,
0.021922005,
-0.027590564,
-0.020457853,
0.0131102195,
0.008469256,
0.0035898627,
0.0012878507,
0.022620501,
-0.021465298,
-0.0051043886,
-0.060876552,
0.0183355,
0.014131097,
-0.013714686,
0.027617428,
-0.0023775706,
0.002211342,
-0.02973978,
-0.021156348,
-0.006115192,
-0.032668088,
0.0055342317,
0.015810173,
0.0038820219,
-0.00419433,
0.012996042,
0.06517498,
-0.021720517,
0.0074215126,
0.039062005,
-0.026663715,
-0.0071058464,
-0.0048961835,
0.025615972,
-0.021962304,
-0.0055879625,
-0.019020565,
0.015675846,
-0.011249804,
0.011968448,
0.006612198,
-0.048303634,
-0.0059002703,
0.0028728978,
0.011921434,
0.007831207,
-0.011008017,
0.011142343,
0.028127868,
0.027012963,
-0.0138758775,
-0.038524702,
0.018819075,
-0.018631019,
-0.017099703,
-0.024863746,
-0.031835265,
0.003057596,
0.008798354,
-0.02550851,
0.0071327114,
0.011840838,
0.010014004,
-0.02168022,
0.0039189616,
-0.016428072,
-0.013929608,
-0.003754412,
-0.011646066,
-0.029229341,
0.026959231,
0.01889967,
0.010188628,
0.020363824,
-0.0040935855,
-0.00037611285,
-0.027590564,
0.004933123,
-0.019638464,
-0.02349362,
-0.0226608,
0.0035562813,
0.033420313,
0.0097319195,
-0.0070051015,
0.0150848115,
-0.032560628,
-0.0018402664,
-0.0071394276,
0.010282656,
-0.006991669,
-0.01327141,
-0.02525329,
0.017489247,
0.0336621,
0.002815809,
0.026569687,
0.04027094,
-0.013452751,
0.0055711716,
0.013358722,
0.014628103,
0.016159419,
0.018026551,
0.023560783,
0.029820375,
-0.03051887,
-0.0054133385,
-0.0010309522,
-0.0012895297,
-0.008576716,
0.01414453,
0.009322225,
-0.023413025,
-0.011867704,
0.013741552,
-0.05706169,
-0.04569771,
-0.020310095,
-0.005359608,
0.010007288,
-0.0061319824,
0.030841254,
0.0071998746,
-0.016750455,
0.0007379536,
0.013311708,
-0.0013247903,
-0.014157962,
0.012606497,
0.013385587,
0.014480345,
0.0018033268,
0.007871505,
0.015353464,
0.022983182,
0.033581503,
-0.017569844,
0.021962304,
-0.031405423,
0.009328942,
-0.02839652,
-0.03299047,
-0.001550626,
-0.018147444,
-0.007078981,
-0.018617585,
0.01910116,
-0.019786222,
0.0844642,
0.010470713,
0.015246003,
-0.012082625,
-0.00054318085,
0.024850313,
0.016602695,
0.014386317,
0.00045586893,
-0.030330814,
-0.0012223667,
-0.022257822,
0.032560628,
-0.029336803,
-0.0065013794,
-0.004308507,
-0.020968292,
0.0034219553,
-0.0028611443,
-0.010047586,
-0.0019091085,
-0.02601895,
0.013177382,
0.017878793,
-0.026811473,
0.009799083,
0.025360752,
0.0057961675,
0.0077170297,
-0.019799655,
0.029981567,
-0.017113134,
-0.04188285,
-0.008099859,
0.008193887,
-0.008959546,
-0.016750455,
-0.017623574,
0.006766673,
0.021035453,
0.005967433,
-0.012143072,
-0.012257249,
-0.030948713,
-0.004479773,
0.0018872805,
-0.025266724,
-0.015689278,
-0.030465141
] |
Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the FANTOM web resource (http://fantom.gsc.riken.jp) to facilitate researchers to explore transcriptional regulation and cellular states. In the course of the collaboration, primary data and analysis results have been expanded, and functionalities of the database systems enhanced. We believe that our data and web systems are invaluable resources, and we think the scientific community will benefit for this recent update to deepen their understanding of mammalian cellular organization. We introduce the | [
-0.027048467,
-0.023961049,
-0.014430323,
-0.022390492,
-0.0039834403,
0.017423777,
-0.034525387,
-0.005513726,
-0.017517742,
-0.015987456,
-0.003364279,
0.010926775,
0.01804126,
-0.0041814377,
0.009221983,
0.00014608605,
0.031008415,
-0.010087803,
-0.028592175,
-0.014363205,
0.003570666,
0.01343698,
-0.035089176,
-0.0015596495,
0.0006531399,
0.004909666,
0.004782142,
-0.0478684,
-0.011014028,
-0.0073359734,
0.014618253,
-0.01653782,
-0.0074299383,
-0.014121582,
-0.0018960773,
-0.011597953,
0.0032837375,
-0.013296032,
0.007906475,
-0.009584419,
0.009993838,
0.020027947,
0.01317522,
-0.012497331,
0.0041277437,
-0.010678439,
0.010443527,
-0.0068124547,
-0.009403201,
0.008550805,
0.006161412,
0.015920337,
-0.0035941573,
-0.0039498815,
-0.030659404,
0.009443472,
-0.014282664,
0.026524948,
-0.007564174,
0.002144413,
-0.0060036858,
0.018672166,
-0.024323484,
0.008671617,
-0.00422842,
-0.0115643935,
-0.012960443,
0.003721681,
-0.0017098255,
-0.011061011,
0.034525387,
0.019303074,
-0.00032447252,
0.0144168995,
0.034793857,
-0.009215271,
0.0008075108,
0.0027316937,
-0.024390602,
0.010624745,
0.01113484,
-0.0010604609,
-0.010624745,
0.009906584,
0.012054354,
0.0015319634,
0.015262583,
0.027947845,
0.03796182,
-0.005483523,
0.016390162,
0.017947296,
0.023370411,
0.008624635,
-0.02808208,
0.0010822742,
0.00005589653,
0.014403476,
0.0054264725,
-0.016363315,
-0.013349727,
0.010148209,
-0.007886339,
-0.010960334,
-0.018779555,
-0.0072151613,
0.03216284,
-0.013040985,
0.0035169718,
0.004020355,
-0.005540573,
0.027571985,
-0.018296307,
-0.025209438,
0.015705561,
-0.022028057,
0.022148868,
-0.00702052,
-0.014591406,
0.0025085271,
0.023531495,
0.0070473673,
0.014363205,
-0.00815481,
0.022135444,
0.016443856,
0.0052519664,
-0.006265445,
-0.012913461,
-0.016900258,
0.014752489,
-0.01547736,
0.04322385,
0.010181768,
-0.031599052,
0.029531823,
-0.026471253,
-0.020336688,
-0.003057215,
-0.025786651,
0.021826703,
0.03922363,
-0.022927435,
-0.0059734825,
-0.02283347,
0.021316608,
0.018752709,
0.011638223,
0.024148978,
0.0032300432,
0.0033458215,
-0.009940144,
-0.0032166196,
-0.007893051,
0.026699454,
-0.005903009,
0.0044096382,
0.029155964,
0.01562502,
-0.010544203,
0.003360923,
0.025008086,
0.010094514,
0.0027384055,
0.022417339,
0.039599493,
0.0023826812,
-0.010779115,
0.005768773,
-0.012752378,
-0.022001209,
0.00400022,
-0.01381284,
0.012054354,
-0.02333014,
0.010658304,
-0.009973702,
0.0084971115,
-0.044109806,
-0.019262804,
0.0050405455,
-0.00010801768,
0.0056781643,
0.009188425,
-0.01426924,
0.012389943,
0.014188699,
-0.011034164,
0.011886559,
-0.024927543,
-0.0014396764,
-0.0002774901,
0.02162535,
0.0047318037,
-0.64476025,
0.004090829,
0.034525387,
-0.041344553,
-0.009141442,
0.01306112,
0.0044700443,
-0.01332288,
-0.010651592,
0.03570666,
-0.023880506,
0.006842658,
0.014806183,
-0.03589459,
-0.036861084,
-0.012685261,
-0.011248941,
-0.0015806238,
0.003993508,
0.009141442,
-0.02124949,
0.008356164,
-0.012611431,
0.007859493,
0.012920173,
0.0018792979,
0.021920668,
-0.002634373,
-0.0044633327,
0.021182371,
-0.03041778,
0.009141442,
-0.005842603,
-0.020900477,
0.049318146,
0.00981262,
-0.0045875004,
0.030364085,
0.015638443,
0.024551684,
-0.017329812,
-0.0013482284,
0.034256916,
0.027008196,
-0.037612803,
0.019074874,
0.014806183,
-0.001603276,
0.009819332,
-0.0012685261,
0.0022316664,
-0.0034901246,
-0.012651701,
-0.0022199207,
0.0037015458,
0.010181768,
0.014806183,
0.00333072,
0.0069131316,
-0.0023356988,
0.0068493695,
-0.011349617,
-0.0067889635,
-0.02110183,
-0.011691918,
0.027263243,
0.010114649,
0.020229299,
0.015678713,
-0.0049499366,
0.02116895,
0.018994333,
-0.009631402,
0.006862793,
0.018188918,
0.02589404,
0.0025622214,
-0.0011183501,
0.0036847661,
0.019222533,
-0.0019564833,
0.0013138306,
-0.007450074,
-0.0013188644,
0.015423667,
-0.0024078505,
-0.029451283,
0.0014874978,
0.005476811,
-0.0016242503,
0.0128799025,
-0.031196345,
0.010423391,
-0.03699532,
-0.024685921,
0.008584364,
-0.0041915053,
0.01710161,
-0.024618803,
-0.031921215,
-0.014873301,
-0.0028793528,
0.019168839,
-0.01543709,
0.011242229,
0.0058795176,
-0.012275842,
0.015893491,
0.031411123,
-0.01728954,
-0.012215436,
0.01053078,
-0.008899818,
-0.004060626,
-0.010470374,
-0.031545356,
0.029021729,
0.010665015,
-0.02374627,
-0.018886944,
0.00962469,
0.0071211965,
0.0016972409,
-0.003842493,
0.022578422,
0.016242504,
-0.0019766188,
-0.04220366,
-0.006238598,
0.01887352,
0.0066580838,
-0.019168839,
0.006258733,
-0.030256696,
0.050445724,
0.017745942,
0.024430873,
0.015034383,
0.013269185,
-0.01222886,
-0.03710271,
-0.028860645,
-0.005262034,
-0.0045472295,
-0.021652196,
-0.0048257685,
-0.027075313,
-0.005637894,
0.029827142,
0.013705451,
-0.032511853,
0.012604719,
0.0053660665,
0.01702107,
0.015383395,
-0.016900258,
-0.0132087795,
-0.031652745,
0.008919953,
-0.022363644,
-0.00013748658,
0.014752489,
-0.00966496,
0.00029196235,
0.012913461,
-0.015799526,
-0.023236176,
0.024028165,
-0.00811454,
-0.035196565,
0.0036109367,
-0.030713096,
-0.012598008,
0.024591954,
-0.0017182152,
-0.0071816025,
-0.002115888,
-0.007859493,
-0.013296032,
-0.01600088,
-0.0003116782,
-0.0108999275,
0.0012349671,
-0.022940857,
0.029263353,
0.01883325,
0.037881278,
-0.0016057929,
-0.027947845,
0.00071354595,
-0.01030258,
-0.004966716,
-0.013423556,
-0.0020084996,
-0.012463772,
-0.0048593273,
0.0004958326,
0.008664906,
-0.006869505,
0.028028386,
0.012309401,
-0.00826891,
0.011799306,
-0.018309731,
0.0120006595,
-0.0071077733,
0.006594322,
-0.016430434,
-0.008450129,
-0.014363205,
0.008141387,
-0.00096565706,
0.0000441247,
0.00052393816,
0.031464815,
0.0011602987,
-0.0037351046,
-0.021262914,
-0.040270668,
-0.00556742,
0.0023407326,
0.0038928313,
0.027263243,
0.013242339,
0.0044331294,
-0.010336138,
-0.006859437,
0.03076679,
0.02189382,
0.005517082,
-0.013094679,
0.014161852,
0.00015898525,
-0.010047532,
0.020390382,
-0.026243053,
0.0043425206,
-0.01883325,
0.02835055,
0.01645728,
0.0036981897,
0.009779061,
0.032055452,
-0.00936293,
0.015584749,
-0.026753148,
-0.0022249545,
0.011262364,
-0.025343675,
-0.00048912084,
-0.016363315,
0.0040639816,
-0.02343753,
0.016846564,
0.012074489,
-0.014430323,
-0.005560708,
-0.02835055,
0.03310249,
0.028484786,
0.017571436,
0.0040841172,
-0.012014083,
-0.0026561862,
-0.008980359,
-0.0050707483,
0.02872641,
-0.0012400011,
-0.015034383,
-0.004933157,
-0.012497331,
0.008369587,
0.010000549,
-0.023263024,
0.00008305826,
-0.0070943497,
0.006352698,
0.017329812,
0.009443472,
0.015504207,
0.0014371595,
-0.040109586,
0.008544094,
0.014510864,
0.011275788,
-0.010101226,
-0.007906475,
-0.02041723,
-0.010436815,
-0.0077521037,
0.022618692,
-0.0008742091,
0.010550915,
-0.008631347,
-0.009430048,
-0.01132277,
0.01271882,
-0.02041723,
-0.013571216,
0.008960224,
0.010564339,
-0.003597513,
0.00902063,
-0.014255817,
0.045344774,
-0.0020605158,
-0.019558122,
-0.011329481,
-0.0041881497,
-0.019746052,
-0.00006470574,
0.0068225227,
0.016175386,
-0.03318303,
-0.014349782,
-0.0065607633,
0.0022350221,
0.014712218,
0.01637674,
0.0024665785,
-0.008946801,
-0.052190788,
0.0060372446,
0.002991775,
0.024820156,
0.010282444,
0.0022954282,
-0.00021813279,
-0.024847003,
-0.011094569,
-0.02351807,
-0.026135664,
0.012215436,
-0.014202123,
-0.0007169018,
0.021987785,
0.031303734,
0.003449854,
0.01932992,
0.0011863068,
-0.0053459313,
-0.02445772,
-0.030847333,
-0.014967266,
0.0024061725,
-0.013947075,
0.02668603,
0.029773448,
0.022108598,
-0.009859602,
0.0094770305,
0.017759366,
-0.017584858,
-0.014376629,
-0.010597898,
0.015128348,
-0.018900367,
0.022779776,
-0.00477543,
0.004134455,
0.0053123725,
0.0037619516,
0.008396435,
0.015128348,
-0.0028843866,
0.014940418,
0.010732133,
-0.00939649,
0.0016318011,
0.010618033,
-0.009933432,
0.022444187,
0.011799306,
-0.007537327,
0.011537546,
-0.0051982724,
-0.011853,
-0.009081036,
0.022860317,
-0.0028407602,
-0.016443856,
-0.001242518,
-0.009188425,
-0.025008086,
-0.004936513,
-0.0061312094,
-0.0052486104,
-0.01864532,
-0.017047917,
0.0006875378,
-0.0234778,
-0.017195575,
-0.020054793,
-0.011685206,
0.007940033,
-0.035975132,
-0.034364305,
0.01506123,
0.028484786,
-0.0010663337,
0.0093763545,
-0.005805688,
0.004543874,
0.022471033,
-0.010141497,
-0.01683314,
-0.014900148,
-0.03095472,
-0.0032837375,
-0.011651647,
-0.016551245,
-0.027370632,
-0.0046311268,
0.008215217,
0.0035639543,
0.003600869,
0.023732848,
0.0074970564,
0.003990152,
0.021611925,
0.018363426,
0.010047532,
-0.0016813005,
-0.026833689,
0.027867302,
-0.017732518,
0.0047116685,
-0.010450238,
0.0098059075,
0.004899598,
-0.0026494744,
-0.00302869,
-0.018967485,
-0.01724927,
0.020296417,
-0.016027726,
0.020162182,
0.0016695549,
0.023048246,
0.00422842,
0.016027726,
0.019611815,
0.007503768,
-0.020229299,
-0.01075898,
-0.017504318,
0.03320988,
0.02551818,
-0.02343753,
0.03589459,
-0.0041915053,
-0.002515239,
-0.041988883,
0.0022064971,
0.0058895852,
0.03865984,
0.004231776,
-0.026914231,
-0.013141662,
0.0016586481,
-0.0128799025,
0.0017970786,
-0.019155415,
0.0029213014,
-0.02306167,
-0.011886559,
0.0065540513,
-0.008349452,
0.0032887713,
-0.031786982,
0.0027434393,
-0.00029196235,
0.023182482,
0.011463718,
-0.022215987,
0.0049230894,
-0.010725422,
0.009524013,
-0.025222862,
-0.03774704,
-0.015718985,
-0.020256147,
0.051277984,
0.039116245,
0.031088958,
0.006386257,
0.009799196,
0.034364305,
-0.004715024,
-0.0012869835,
-0.011201958,
0.02166562,
-0.009040765,
0.006654728,
0.0030001649,
0.016175386,
-0.010054244,
-0.0012148318,
0.018014412,
0.026471253,
-0.0070339437,
-0.020430652,
0.019732628,
-0.02608197,
-0.020296417,
0.009309236,
0.0014975655,
0.009792484,
-0.040915,
-0.006711778,
0.045049455,
0.003537107,
0.016202232,
0.020739395,
0.017907023,
-0.020564888,
0.005691588,
0.0081682345,
0.01679287,
-0.03060571,
-0.016202232,
-0.013114815,
-0.019464158,
0.02083336,
0.0062889364,
0.021155525,
0.02133003,
-0.006231886,
0.010665015,
-0.00023805839,
-0.011772459,
0.00020061925,
-0.021356879,
0.010960334,
-0.038713537,
-0.00902063,
-0.00411432,
-0.013591351,
0.006664796,
0.012933597,
-0.02827001,
0.03189437,
-0.021786433,
-0.023799965,
0.022699233,
-0.0004899598,
0.029612366,
-0.0043593,
0.013947075,
0.02385366,
0.0204575,
-0.029800296,
-0.01668548,
-0.017128458,
-0.0061647682,
0.034659624,
0.01962524,
-0.032431312,
-0.028968034,
0.02422952,
0.018537931,
-0.024148978,
-0.06368135,
0.0046479064,
0.011933542,
0.010436815,
-0.034928095,
0.014577982,
-0.015074654,
0.0012769158,
-0.031760134,
0.0035538867,
-0.00052100176,
-0.020162182,
-0.009980414,
0.022403916,
-0.0058929413,
0.00320823,
-0.018470814,
-0.0058560264,
0.021450844,
0.00230214,
-0.01075898,
-0.012638278,
-0.009530725,
0.024618803,
0.00920856,
-0.023732848,
0.0239342,
0.0032434668,
-0.0083830105,
-0.0021393793,
-0.020108487,
0.03229708,
-0.003120977,
-0.003080706,
0.012685261,
0.022793198,
-0.0028105571,
-0.006513781,
0.0032250094,
-0.016470704,
-0.023638884,
0.004382791,
0.016430434,
-0.001753452,
-0.0040438464,
-0.0041310997,
-0.01920911,
-0.0144168995,
0.0010705286,
-0.02098102,
0.0029582162,
-0.06153358,
-0.01483303,
0.036055673,
0.026820267,
0.032216534,
0.0032132638,
-0.017168729,
0.0010478763,
0.04349232,
-0.010403256,
0.037263792,
0.027343784,
-0.03229708,
-0.03664631,
0.011107993,
-0.012745667,
-0.023558341,
-0.013551081,
-0.03358574,
-0.023920778,
0.001694724,
0.028055232,
0.014577982,
0.003235077,
-0.012577873,
0.029907683,
0.0056714527,
0.021491114,
-0.002540408,
-0.024175825,
0.0066043898,
-0.009745502,
0.00037271343,
0.014658524,
-0.0035773779,
0.021652196,
0.010128073,
-0.03031039,
0.009893161,
-0.02343753,
-0.01683314,
-0.009658249,
0.020578312,
-0.020068217,
0.009490455,
-0.01483303,
-0.021813279,
-0.023115365,
0.016886834,
0.013383286,
-0.0033844141,
-0.0026847112,
-0.006960114,
0.027276667,
0.008705176,
-0.02208175,
0.005866094,
-0.010866369,
-0.030149307,
-0.036324143,
-0.0033407875,
-0.0234778,
0.015732408,
0.0105777625,
-0.030927874,
-0.053774767,
0.012014083,
-0.025048357,
-0.0385793,
0.0077051213,
0.027571985,
0.017316388,
0.009302525,
0.017920448,
0.0047720745,
-0.0011686884,
-0.011061011,
0.0018574846,
-0.007597733,
-0.007913186,
0.015463937,
0.014604829,
-0.0116248,
-0.05133168,
-0.007940033,
0.010081091,
-0.021920668,
-0.005513726,
0.019370193,
-0.025330251,
0.04623073,
-0.019034604,
0.018631896,
-0.028753258,
0.024377178,
0.040780764,
-0.0145242885,
0.0044096382,
0.01849766,
-0.004329097,
-0.016524399,
0.020403806,
0.004580789,
-0.009087748,
0.012604719,
-0.0024263079,
-0.022095174,
0.01524916,
0.0064802216,
0.0144168995,
0.023987895,
-0.02339726,
0.011410023,
0.0065607633,
-0.007470209,
-0.022068327,
0.002357512,
-0.0005520438,
-0.0009169967,
0.003990152,
-0.0032266874,
0.0025974582,
-0.0001938026,
-0.0019631952,
-0.0316259,
-0.0073158382,
-0.012356384,
-0.027222972,
-0.03095472,
-0.011799306,
-0.0014916927,
-0.029424436,
-0.027196126,
-0.008671617,
-0.0001938026,
-0.011490564,
0.0079534575,
-0.020470923,
-0.0051781368,
0.0016720718,
0.008651482,
-0.013712163,
0.005929856,
-0.0039666607,
-0.0026662538,
-0.022940857,
0.020725971,
0.18696329,
-0.02891434,
0.0028978102,
0.02800154,
-0.0059265,
-0.02060516,
-0.0031243328,
0.004986851,
0.005923144,
-0.008866259,
0.015786102,
0.015718985,
-0.0033474993,
0.0016569702,
0.027733067,
-0.00217965,
-0.01313495,
0.00062797073,
-0.028833799,
0.00045388401,
0.013383286,
-0.01614854,
-0.01822919,
-0.0035605982,
0.032431312,
0.0019262803,
-0.012302689,
0.007866204,
-0.0033441435,
0.026766572,
-0.016712328,
0.020202452,
0.009960279,
0.020162182,
-0.009094459,
0.0011275788,
0.01294702,
0.009074324,
-0.0023843592,
0.0049801394,
-0.007718545,
0.009779061,
-0.006023821,
-0.009718655,
0.020162182,
-0.00077059603,
0.020444077,
-0.000697186,
-0.017786212,
0.006778896,
-0.04827111,
0.009087748,
0.025088627,
0.036619462,
-0.0030706385,
-0.0020538042,
-0.000967335,
0.026511524,
0.001300407,
0.040378056,
-0.015638443,
0.002203141,
-0.010349562,
0.022229409,
-0.04566694,
0.009873026,
-0.00671849,
0.036055673,
0.020752817,
-0.021759585,
-0.009067613,
0.011618088,
-0.022430763,
0.016282775,
-0.022390492,
-0.025048357,
0.0024296637,
0.015423667,
0.015598172,
0.024699343,
0.018591626,
0.0044532646,
-0.021007866,
-0.012175166,
-0.011248941,
-0.020538041,
0.019893711,
0.0005373617,
-0.0114502935,
-0.028833799,
0.003506904,
0.0058124,
-0.009537437,
-0.017544588,
-0.003993508,
0.017517742,
-0.009221983,
0.0070272316,
0.018578202,
-0.032431312,
-0.039438408,
0.04730461,
0.0039465255,
0.0106851505,
-0.009034053,
0.0018289596,
-0.016940529,
0.028887494,
-0.017651977,
0.0038961873,
0.010389833,
-0.007483633,
0.002146091,
0.002933047,
0.030015072,
0.009235407,
0.0135376565,
-0.016766021,
0.011154976,
0.00034209093,
-0.015880067,
-0.035089176,
0.0117389,
0.021531384,
-0.010564339,
0.00992672,
0.005359355,
0.013631621,
-0.014510864,
-0.01506123,
0.0067554046,
0.0007655622,
0.028511634,
-0.022444187,
-0.005050613,
-0.02608197,
-0.011477141,
0.009383066,
-0.031733286,
-0.0033172963,
-0.028162621,
0.0011435192,
0.020175606,
0.02155823,
-0.0117858825,
-0.00943676,
0.03133058,
0.00077982474,
-0.011403311,
-0.005929856,
0.002152803,
-0.003052181,
-0.0073628207,
-0.012517466,
0.045076303,
-0.004715024,
0.011074434,
-0.033048797,
-0.0024632227,
-0.016886834,
-0.029370742,
-0.0043727234,
0.040565986,
-0.006292292,
-0.0035740219,
0.0039498815,
-0.17074764,
-0.00028546032,
0.016363315,
-0.04284799,
0.027840456,
-0.011376464,
0.02577323,
-0.0013205424,
-0.012141607,
-0.014859877,
0.01966551,
0.0024649005,
-0.03801551,
-0.019799747,
0.015329702,
0.0018054683,
-0.01808153,
0.027410902,
0.017719094,
-0.003021978,
0.019504428,
-0.004580789,
-0.0081682345,
-0.02133003,
-0.003209908,
0.03264609,
-0.00079408725,
0.0071816025,
-0.021410573,
-0.036001977,
-0.016980799,
-0.00043416815,
0.014873301,
-0.0070675025,
0.017007645,
0.024175825,
-0.013839686,
-0.007933321,
-0.020202452,
0.021491114,
0.019195685,
0.03589459,
0.0027618967,
-0.007530615,
-0.0048526158,
0.023316717,
0.029343894,
-0.006137921,
0.025947735,
-0.012846343,
0.011886559,
0.00081799796,
0.024900697,
-0.00094887766,
0.014242393,
0.014014193,
-0.00087588705,
0.015463937,
0.026551794,
-0.011027452,
-0.01706134,
-0.012685261,
0.02528998,
0.0055271494,
0.002631017,
-0.013665181,
-0.028377399,
0.008067558,
-0.013906805,
0.0012064421,
-0.035035484,
0.003147824,
-0.003664631,
-0.008255487,
0.015960608,
-0.00064684765,
-0.012175166,
0.011832865,
0.0232496,
-0.0029766737,
-0.0059432797,
0.00070054183,
-0.019826593,
-0.015168618,
0.00058476365,
-0.007168179,
0.0086044995,
0.009242118,
-0.0018272817,
0.016940529,
0.031196345,
-0.016510975,
-0.0030924517,
-0.004564009,
0.024900697,
0.02612224,
-0.003354211,
-0.013094679,
0.0068862843,
-0.012202012,
0.021732738,
0.0050002746,
-0.0069332668,
-0.0037451722,
0.01920911,
0.010879792,
-0.0006233564,
-0.0039263903,
0.059654284,
-0.010960334,
-0.011544258,
0.013457116,
0.019678934,
0.022551576,
0.0046109916,
0.013195356,
0.005325796,
-0.007255432,
-0.00943676,
-0.014363205,
0.07200395,
0.030471474,
-0.0023558342,
0.026565218,
-0.008470264,
-0.0020974306,
-0.11748297,
-0.027021619,
-0.012826208,
0.019799747,
-0.017235847,
0.01883325,
0.0067889635,
0.03702217,
-0.019410463,
0.03095472,
-0.017665401,
-0.027545137,
-0.003634428,
-0.0065506957,
-0.0016351569,
0.0093696425,
-0.028806953,
-0.019558122,
0.0022820046,
0.02747802,
0.020994442,
-0.0062251743,
0.012497331,
-0.011691918,
0.0016703937,
-0.010711998,
-0.02528998,
0.0069735376,
0.010195191,
-0.0041378113,
0.007295703,
-0.022283103,
0.021987785,
-0.023142211,
-0.028860645,
-0.024551684,
-0.009034053,
-0.014940418,
0.010087803,
-0.004933157,
-0.010443527,
0.00089350546,
0.010624745,
0.015611596,
-0.010423391,
-0.00047276088,
0.006433239,
0.008705176,
0.019920558,
-0.020846782,
-0.010067667,
-0.02966606,
-0.010369698,
-0.015088078,
0.011443581,
-0.0076380037,
0.016631786,
0.004678109,
-0.003842493,
0.01608142,
-0.010564339,
-0.019155415,
0.004986851,
0.018846674,
-0.005023766,
-0.001512667,
-0.0073628207,
-0.011161687,
0.034095835,
-0.0047955657,
0.011148264,
0.011732188,
-0.00920856,
-0.0267263,
-0.021034712,
-0.0037418164,
-0.0234778,
0.014551135,
0.010470374,
-0.01849766,
0.011759035,
-0.02577323,
-0.0038827637,
0.008859547,
0.029827142,
-0.012396654,
0.003359245,
-0.009443472,
-0.00039410722,
-0.030390931,
-0.01192683,
0.024833579,
0.0028021673,
-0.027384056,
-0.025719535,
0.006356054,
-0.0011149942,
0.00936293,
-0.006862793,
0.018309731,
-0.02762568,
-0.005903009,
-0.062822245,
0.0016057929,
-0.0014841419,
-0.014685371,
0.015786102,
-0.007966881,
0.0047955657,
0.0048794625,
0.0051546455,
0.005496946,
-0.020846782,
0.020363536,
0.0019279583,
-0.021034712,
-0.021491114,
-0.02120922,
0.01943731,
0.016484126,
0.023048246,
0.026337018,
-0.000333072,
0.022390492,
0.039438408,
0.01804126,
0.0013574571,
0.00526539,
-0.024820156,
0.017987566,
-0.0066111013,
-0.0028877426,
-0.006476866,
-0.014765912,
-0.012671838,
0.0031562138,
-0.006174836,
-0.026578642,
-0.014067887,
0.010443527,
0.008376299,
0.049881935,
-0.011597953,
-0.023182482,
0.006382901,
-0.021074984,
0.008691752,
0.013584639,
-0.031115804,
0.0040975404,
0.0016418687,
-0.0019111788,
0.00072487205,
-0.0008305826,
-0.013504098,
-0.024565108,
0.01253089,
-0.00011221254,
0.0026779994,
0.00015520987,
0.014712218,
-0.0073359734,
0.003052181,
0.0074634976,
0.014094735,
-0.0046143476,
-0.015678713,
-0.011222093,
-0.027545137,
0.005480167,
0.03216284,
-0.03087418,
-0.025330251,
0.0076111564,
0.0059499913,
0.007080926,
0.013483962,
-0.009638114,
-0.009819332,
0.010262309,
0.0060338886,
0.042633217,
0.04585487,
-0.016980799,
-0.013269185,
0.03307564,
0.035008635,
0.0037451722,
-0.010926775,
0.0003802642,
-0.0044566207,
0.020014523,
-0.020618582,
0.022551576,
0.008617924,
0.0072487206,
-0.0076178685,
0.022820046,
0.0015957253,
0.020202452,
0.01710161,
0.02845794,
0.013423556,
0.013296032,
0.013960498,
-0.016323045,
-0.022752928,
0.008463552,
-0.030390931,
-0.025545027,
-0.003419651,
0.015987456,
0.0008289046,
-0.004480112,
-0.0047687185,
0.008127963,
-0.02064543,
0.029451283,
-0.0047922097,
-0.020229299,
-0.019544698,
0.022256257,
0.026900807,
0.0073091267,
0.006201683,
-0.012725531,
0.021960938,
0.027263243,
0.027947845,
-0.044244044,
0.017504318,
0.007852781,
-0.006664796,
0.01094691,
-0.009819332,
-0.0009648181,
-0.021491114,
0.007228585,
0.0018994332,
-0.0031914506,
-0.007913186,
0.08413885,
-0.00773868,
-0.01547736,
0.004634483,
-0.019638663,
-0.009047477,
0.011336193,
0.02835055,
-0.020524617,
0.0015596495,
0.028968034,
-0.0077118333,
-0.0026108818,
-0.030390931,
-0.022712657,
0.04585487,
-0.030981569,
0.007604445,
-0.012356384,
-0.002117566,
0.016484126,
-0.015101501,
0.0047620065,
0.006748693,
-0.03280717,
0.0010176734,
0.01879298,
0.011248941,
0.0064835777,
-0.015329702,
0.015584749,
-0.0081682345,
-0.050069865,
0.024417449,
0.0021947515,
-0.015692137,
0.00048870133,
-0.023115365,
0.007114485,
0.03589459,
-0.0033021949,
-0.026887383,
-0.013155085,
-0.011557682,
-0.0017056307,
0.0031964844,
0.00005799396,
0.0015395142,
-0.009685096
] |
Multidrug-resistant tuberculosis (MDR-TB) is a growing public health problem. Due to long duration of therapy and concurrent use of multiple second-line drugs, adverse drug events (ADEs) are regarded as the most important clinical consideration in patients undergoing anti-MDR-TB treatment. To evaluate the frequency and type of treatment-related ADEs owing to MDR-TB therapy. The Cochrane Library, MEDLINE, and EMBASE were searched from inception through October 1, 2012, with additional manual search of International Journal of Tuberculosis and Lung Disease. Studies with available ADEs were selected if M | [
-0.012273352,
-0.021313401,
-0.006331334,
-0.045978878,
0.0070604766,
0.034682117,
-0.0046025068,
0.007489384,
-0.03262336,
0.010372962,
0.0012438316,
0.018027311,
0.019254645,
0.017578607,
-0.005186481,
-0.011250572,
0.032834515,
0.010287181,
-0.0046289014,
-0.019307435,
-0.018977506,
0.00018816252,
-0.024256365,
0.00021177306,
-0.0010491736,
0.0007435771,
0.015084345,
-0.033388797,
-0.021867681,
-0.0055625997,
0.007594961,
-0.0010013339,
-0.0023655896,
0.0034741503,
-0.0012735252,
0.01256369,
0.005763856,
0.007364011,
0.016918749,
-0.0030254473,
0.00231775,
0.0035830268,
0.014912782,
0.027872385,
0.0002583755,
-0.0016257243,
0.021115445,
-0.012854027,
-0.024480717,
-0.005133692,
0.0093501825,
0.013883404,
-0.018542,
0.005595593,
0.009020254,
-0.022831073,
-0.028241906,
0.03531558,
0.017499425,
-0.034048654,
-0.033837497,
-0.00857155,
-0.033731923,
0.0014995264,
-0.021168232,
0.0139493905,
-0.009271,
0.010848059,
0.017077114,
-0.00012588846,
0.04267959,
0.0143848965,
0.018093295,
-0.010722687,
0.016839566,
-0.03003672,
-0.004180198,
0.017024327,
0.0066117733,
0.021748908,
0.0012380579,
0.010168406,
-0.007443194,
0.014002179,
0.022738693,
0.017037524,
0.016232498,
-0.006067391,
0.002507459,
-0.004206592,
-0.008809099,
0.0008743114,
0.012926611,
0.0282683,
-0.0053943363,
0.0142397275,
0.026169954,
0.031066097,
-0.017314663,
-0.02002008,
-0.008076658,
0.0018327546,
-0.019399814,
-0.009699907,
-0.019109476,
0.03169956,
-0.016192906,
-0.008083256,
0.0060640913,
-0.008380191,
0.0066744597,
0.055216886,
0.010135413,
-0.01283423,
0.013738235,
-0.005951916,
0.022276793,
-0.012596682,
0.014226531,
-0.027634837,
0.012530697,
0.022224005,
-0.00769394,
-0.017486228,
0.02701457,
0.0050380128,
-0.009950653,
-0.0012727004,
0.016060935,
0.010966834,
0.0056087896,
0.00430887,
0.014780811,
-0.0058331415,
-0.018423226,
0.026090771,
-0.036688086,
-0.009244605,
-0.034497358,
-0.031118885,
-0.0076213554,
0.02942965,
-0.015097543,
-0.022778286,
-0.019069886,
0.05278861,
0.037664674,
0.020323616,
-0.0064303125,
0.01001004,
0.005819944,
-0.02465228,
-0.008439579,
-0.010287181,
-0.0035005447,
-0.0014541612,
0.0015927313,
-0.004285775,
-0.026711037,
-0.015533049,
-0.011151594,
-0.0051501887,
0.02942965,
-0.0035434354,
0.03697842,
0.036952026,
-0.0040812194,
0.005268963,
0.0044738348,
0.0075553698,
-0.009125831,
0.020587558,
0.0033784711,
0.014754416,
0.00991766,
0.013401709,
-0.0027516063,
0.0126098795,
-0.018871928,
-0.017367452,
-0.0016273739,
-0.00034271355,
0.032728937,
-0.0007307923,
-0.03230663,
0.008004073,
-0.006770139,
0.016351271,
0.00017764604,
-0.035896257,
0.014622445,
-0.0004899443,
-0.02446752,
-0.0231742,
-0.6372641,
-0.0077401297,
-0.008274615,
0.0022979542,
-0.019584574,
0.015625428,
0.032940093,
0.027951568,
-0.026803417,
0.020534769,
0.006057493,
0.023939634,
0.037004817,
-0.022593524,
0.010953637,
-0.0042230887,
-0.015862977,
-0.012827632,
0.01848921,
0.006169669,
-0.008723318,
0.026737431,
-0.00611688,
0.010201399,
-0.013817418,
-0.013269736,
-0.0072452365,
-0.016245695,
-0.0007637852,
0.041043144,
-0.016100526,
0.009145627,
0.016113723,
-0.00011650611,
0.050360333,
-0.023240186,
-0.0019960692,
0.02428276,
0.026169954,
0.011408938,
0.0026493284,
0.012524097,
0.01590257,
-0.0036160199,
0.015810188,
0.026447093,
0.016390864,
0.008663931,
0.01955818,
0.008406586,
0.017618198,
0.012167774,
-0.031250857,
-0.0069680964,
0.028453061,
0.022593524,
0.0052161743,
-0.010828264,
0.0070604766,
-0.00917862,
-0.011857642,
0.008795902,
0.004717982,
-0.015625428,
-0.02275189,
0.0016009796,
-0.012847428,
0.0023936336,
-0.002924819,
-0.0051435903,
0.016668003,
0.029456044,
-0.0057440605,
0.014160545,
0.038113378,
0.026803417,
0.0028060446,
0.0020406097,
-0.013896601,
0.015057951,
0.019109476,
0.0065952768,
-0.03703121,
0.007614757,
0.04291714,
-0.013507285,
-0.013157561,
-0.0028357382,
0.0003633341,
0.0062389537,
-0.0008050263,
0.011138396,
-0.0019119375,
-0.023161003,
0.00082647166,
0.016047737,
0.004787267,
0.0007361537,
-0.014015376,
0.0034048653,
-0.052630246,
-0.006331334,
0.022831073,
-0.0023688888,
0.010564321,
0.0006363502,
-0.026908994,
0.0050974,
0.04941014,
-0.013467694,
-0.0028868772,
-0.008987261,
0.005625286,
0.006248852,
0.015876174,
-0.025087787,
0.0009312241,
0.0016240745,
0.0058232434,
-0.032042686,
0.018014112,
0.006994491,
-0.006466605,
0.00007861585,
-0.0015671619,
-0.004292374,
0.027634837,
-0.010214596,
0.017222283,
-0.010280582,
0.011765261,
-0.01705072,
0.021168232,
-0.0051369914,
0.020033278,
-0.0023622904,
-0.009086239,
-0.006037697,
-0.00518978,
-0.025325336,
-0.011046017,
-0.016179709,
0.0019531786,
0.014794008,
0.006446809,
-0.016971538,
-0.0025470504,
-0.0016141767,
-0.019940898,
-0.0059618135,
0.0016092277,
-0.007594961,
0.008076658,
0.024863435,
0.015163528,
-0.013197153,
-0.005460322,
-0.019307435,
-0.026671445,
-0.005734163,
0.011151594,
-0.015612232,
-0.020508375,
0.0034840482,
-0.0036919033,
-0.026394306,
-0.012365731,
0.023411749,
-0.005440526,
-0.030063113,
0.025615674,
-0.027291711,
-0.0014129202,
0.0124317175,
0.0115607055,
0.014648839,
-0.00764775,
-0.0047806683,
0.0077599254,
-0.0023243485,
0.0037149985,
0.023200594,
0.0097329,
-0.0008421433,
0.0008079132,
0.002233618,
0.015467063,
-0.027027769,
0.011098805,
0.029667199,
-0.011686078,
-0.011639888,
-0.019729743,
0.0044573382,
0.0032415506,
-0.004203293,
0.01719589,
0.024757858,
0.015810188,
0.0333624,
0.023583312,
-0.022303188,
0.018251661,
-0.0032976384,
0.011342953,
-0.017961325,
0.0101948,
-0.014371699,
0.03280812,
-0.0044375425,
-0.015242711,
-0.016522834,
-0.0026311823,
0.0058364407,
-0.014226531,
0.042468436,
0.0073904055,
0.002387035,
-0.02201285,
-0.012471309,
-0.019452604,
-0.014450882,
0.008670529,
-0.015189922,
-0.016232498,
-0.003314135,
0.008182234,
0.0053613433,
0.006093785,
-0.006747044,
-0.016390864,
-0.007812714,
0.028848976,
-0.00222372,
0.006822928,
0.024414731,
-0.0063775238,
-0.0069483006,
0.03457654,
-0.014662037,
-0.010947038,
0.0076345527,
0.0030881336,
0.014200136,
0.0028043948,
0.0077335313,
0.0071396595,
0.016140118,
0.008941071,
0.010973432,
-0.02562887,
-0.0057737543,
-0.021709315,
-0.022778286,
-0.01918866,
-0.024203578,
0.021181429,
0.011567304,
0.03452375,
0.022224005,
0.008083256,
-0.0031821635,
0.0061762673,
-0.016390864,
0.025246153,
0.014912782,
0.0011102104,
-0.012576886,
0.0133687155,
-0.008921275,
-0.0208515,
-0.01603454,
0.011666283,
-0.033019274,
0.002942965,
0.0044705356,
-0.03948588,
0.00031673166,
0.004648697,
-0.010366363,
-0.01311797,
-0.017275073,
0.03127725,
0.009891266,
-0.010768876,
-0.030142296,
0.002321049,
0.01316416,
-0.017578607,
0.02386045,
0.008175636,
0.010966834,
0.012926611,
0.025549687,
-0.009211613,
-0.009020254,
0.01784255,
0.0044375425,
-0.0024728165,
-0.00829441,
0.001751922,
0.00026518028,
0.007040681,
-0.006654664,
0.010537926,
-0.0106567005,
-0.00778632,
-0.018542,
-0.02151136,
0.0047443765,
0.010676497,
-0.007707137,
-0.00048045884,
-0.015836583,
0.005899127,
0.02011246,
-0.0115936985,
0.008393389,
0.007020885,
-0.018542,
0.02354372,
-0.035949044,
0.010848059,
0.0019069886,
0.04199334,
0.0004870574,
-0.015638625,
0.015308697,
-0.0074167997,
0.01959777,
-0.0016818121,
-0.01974294,
0.026579065,
0.017591804,
-0.011184587,
-0.017459832,
0.008149242,
0.020706331,
0.010267384,
0.013408307,
0.0006623321,
-0.008314206,
-0.0048466544,
-0.0007489384,
0.021867681,
-0.007964482,
0.0366089,
0.016206102,
0.013018991,
-0.025496898,
-0.007944685,
-0.006935104,
0.014002179,
0.0026707738,
0.005691272,
0.0033339306,
-0.02813633,
0.02512738,
0.00061737926,
0.010900848,
0.019320631,
0.0048400555,
-0.006690956,
0.0042692786,
0.012359133,
-0.0051798825,
0.011877437,
-0.00020703033,
0.013243343,
-0.011837846,
-0.00852536,
0.01557264,
-0.0006264523,
-0.014450882,
0.021181429,
0.010623707,
-0.035790678,
-0.008096453,
0.03317764,
-0.014107756,
-0.002679022,
-0.019716546,
-0.020600755,
-0.005212875,
-0.010709489,
-0.039776217,
0.010201399,
-0.004011934,
-0.021603739,
0.017341059,
-0.024823844,
0.000277965,
-0.013038787,
0.005806747,
-0.012662668,
-0.014424488,
-0.010346567,
0.022421962,
-0.004285775,
0.006446809,
0.007350814,
-0.010848059,
-0.003388369,
0.03127725,
-0.026249137,
0.01631168,
0.004661894,
-0.026209544,
0.011382544,
-0.004810362,
0.008116249,
-0.024190381,
-0.030828549,
0.038166165,
0.0086243395,
-0.028189117,
0.02321379,
0.016060935,
-0.009719702,
-0.01107901,
0.015836583,
0.00783251,
-0.019531786,
-0.027608443,
-0.014635642,
-0.0034279604,
-0.006631569,
-0.0100760255,
0.030327056,
-0.02382086,
-0.021089049,
-0.004995122,
-0.005071006,
-0.01961097,
-0.013276336,
-0.016338075,
-0.015731005,
-0.00079842773,
0.039274726,
0.01218757,
-0.0027004674,
0.013018991,
0.0073904055,
0.0009477205,
-0.008690325,
0.0053745406,
0.029588016,
0.01983532,
-0.011105404,
0.016839566,
0.00020053485,
-0.03961785,
-0.04708744,
-0.024243169,
-0.013698644,
0.040172134,
0.011138396,
0.004843355,
-0.05260385,
-0.0053118537,
-0.018924717,
-0.001923485,
0.0002886877,
-0.009647119,
-0.0072452365,
0.00014640592,
-0.0127550475,
0.0131905535,
0.018687168,
-0.030749366,
-0.007225441,
-0.008875085,
-0.018713562,
0.008406586,
-0.0048697493,
-0.0068163294,
-0.026011588,
0.0102541875,
-0.02590601,
-0.02094388,
-0.014490473,
-0.0149655705,
0.018673971,
0.034075048,
0.012088591,
-0.019056689,
0.013738235,
0.004859851,
0.0053382483,
0.011573902,
-0.021907274,
0.0111251995,
-0.01098663,
0.017829353,
0.03539476,
-0.0059057255,
0.0066249706,
-0.010287181,
-0.00019981313,
-0.007476187,
0.009699907,
-0.019294238,
-0.014200136,
-0.025879616,
-0.023015834,
0.0017040824,
-0.007660947,
0.0074959826,
-0.042283677,
-0.010828264,
0.02155095,
0.024599493,
-0.0074167997,
-0.0005918098,
-0.0066678612,
0.00044375425,
0.019320631,
0.016720792,
0.010392757,
-0.01603454,
-0.018700365,
-0.024269564,
-0.032834515,
-0.008182234,
-0.00080667593,
0.0033619746,
0.021722512,
-0.016245695,
0.0008149242,
-0.00035323005,
-0.022593524,
-0.029271284,
-0.038245346,
-0.0380078,
-0.009369979,
-0.009937456,
-0.0060541937,
-0.016945144,
0.012253556,
0.014767613,
-0.0029990529,
0.030247873,
-0.016522834,
-0.005704469,
0.0037281956,
-0.030617394,
0.0048235594,
-0.0067833364,
0.0027812999,
0.010234391,
-0.0073838066,
-0.0006887264,
0.0012661018,
0.009990244,
-0.021880878,
0.021300204,
0.007581764,
-0.012180972,
0.0037018012,
0.0014310662,
0.007126462,
-0.013065181,
-0.03452375,
0.022949848,
-0.0028703806,
-0.011514516,
-0.012306345,
-0.016140118,
-0.028400272,
0.024032015,
-0.012570288,
0.01658882,
0.006776738,
-0.028400272,
-0.0017321262,
0.0061234785,
-0.032174658,
0.0061333766,
-0.0053349487,
-0.03389029,
-0.018053705,
-0.020653544,
-0.018739957,
-0.014054967,
-0.013883404,
0.023372157,
0.010043033,
0.0048037637,
0.039037175,
-0.007957883,
-0.013606264,
-0.0037083998,
-0.036556114,
0.035553128,
-0.025642067,
0.004285775,
0.012781442,
-0.008182234,
-0.000038534654,
-0.00061737926,
-0.017169496,
-0.0016347973,
-0.021339795,
-0.0129002165,
-0.004717982,
0.018185677,
-0.018172478,
-0.012788041,
-0.015229514,
-0.012702259,
0.012319542,
-0.022765089,
0.027661232,
-0.026037982,
-0.009699907,
-0.0029231692,
-0.012524097,
0.020930683,
-0.010676497,
0.0044045495,
-0.009924259,
0.022289991,
-0.023768071,
0.0066150725,
0.0025998391,
-0.021616936,
-0.00968671,
0.020891093,
-0.0036457134,
-0.03481409,
-0.007990876,
-0.0062125595,
-0.03861487,
-0.024546703,
-0.03729515,
-0.012695661,
-0.007799517,
-0.034655724,
0.033943076,
-0.005047911,
0.0083406,
-0.005625286,
-0.015123936,
0.029403256,
-0.012807837,
0.023108214,
0.023121411,
-0.021432176,
-0.003373522,
0.0048829466,
0.011468326,
0.0032613464,
-0.023504129,
0.0020538068,
0.0068097305,
0.04175579,
-0.019386617,
0.01821207,
0.0033685733,
0.0042098914,
-0.015348288,
0.03948588,
-0.001325489,
0.017776564,
0.005595593,
-0.020033278,
-0.014266122,
-0.010168406,
-0.010135413,
0.011164791,
-0.00403173,
0.0068097305,
-0.033204034,
-0.012761647,
-0.03359995,
0.035526734,
-0.0038403713,
0.002497561,
-0.0025190064,
-0.009211613,
-0.031171674,
0.032095473,
-0.003952547,
0.022857469,
0.024216775,
0.0115936985,
0.0039987373,
0.017961325,
0.02192047,
0.0037974806,
0.0024876632,
-0.0151107395,
0.012372331,
-0.018502409,
0.030115902,
-0.013091575,
-0.070578374,
0.011474924,
0.02937686,
-0.016654806,
-0.021986457,
0.012636273,
-0.004199994,
-0.013659053,
-0.007858904,
-0.009759294,
-0.024203578,
0.017552212,
0.014952374,
-0.010887651,
-0.0077335313,
0.018779548,
0.019254645,
-0.009845076,
0.0010994878,
0.048037633,
0.014728022,
0.0031722656,
-0.00085616525,
-0.015414274,
0.0030138998,
-0.018634379,
0.015493457,
0.0074167997,
0.01881914,
-0.009891266,
-0.0052062767,
-0.003480749,
0.0074497927,
0.0032893904,
0.013553476,
-0.025734447,
0.0071660536,
0.0035764284,
-0.0016611916,
0.012966203,
0.004421046,
0.013711842,
-0.0066447663,
-0.0058265426,
-0.021221021,
-0.0037743857,
0.006192764,
0.007852306,
-0.0013477592,
-0.0035203404,
-0.0042230887,
-0.033019274,
-0.007911693,
-0.01005623,
0.028717004,
-0.027819598,
0.011144996,
-0.025061393,
-0.024810646,
0.018726759,
0.0059849084,
-0.017684184,
-0.016628413,
0.009884668,
0.1908836,
-0.0060442956,
-0.0060739894,
0.0032300032,
0.027397288,
0.006747044,
0.01367225,
-0.01033337,
-0.014437685,
0.031646773,
0.031013308,
0.006770139,
-0.0026641751,
0.008644135,
-0.023702085,
0.020706331,
-0.034418173,
-0.0024942618,
-0.008690325,
-0.0002998228,
0.011712473,
0.00861774,
-0.0015391179,
-0.008762909,
0.015862977,
0.0013749783,
-0.017855747,
-0.0061069825,
0.0040713213,
-0.023504129,
-0.01756541,
-0.03489327,
0.003249799,
0.0023853853,
-0.005427329,
0.002771402,
-0.020442389,
-0.021735711,
0.0056120893,
0.018898323,
0.008762909,
0.037136786,
-0.014635642,
-0.0097329,
-0.0054207304,
0.020732727,
-0.0034609532,
-0.011573902,
-0.0028027452,
-0.017670987,
-0.011626692,
-0.017987719,
0.0020241132,
0.011699276,
0.0056153885,
-0.01357987,
0.0066513647,
0.022210808,
-0.016654806,
0.006994491,
-0.016008146,
-0.014002179,
-0.03389029,
0.037664674,
-0.0092050135,
0.04629561,
-0.036081016,
0.018871928,
0.028479455,
-0.0019498792,
-0.0042758775,
-0.022421962,
-0.009303993,
0.018146085,
0.008050263,
-0.014002179,
-0.00051881303,
0.018739957,
0.0329137,
0.027634837,
0.0026955183,
-0.021379387,
-0.02632832,
0.015533049,
-0.04360339,
-0.022501145,
-0.009369979,
0.027186135,
-0.021339795,
0.020138854,
0.0018327546,
0.012616478,
-0.020218037,
0.021075852,
0.032834515,
0.02215802,
0.0057473597,
-0.019017097,
0.009172021,
-0.035764284,
-0.02586642,
0.099876046,
-0.03328322,
0.008241622,
-0.019584574,
0.0014632343,
-0.02210523,
0.013131167,
0.012576886,
-0.0065193935,
0.017736973,
-0.020732727,
-0.011804853,
-0.022870665,
0.019663757,
0.016852764,
0.022791483,
-0.01385701,
-0.001890492,
-0.030221479,
0.019729743,
-0.032544177,
-0.0061828657,
0.010135413,
-0.012939808,
-0.013388511,
0.0023540421,
-0.02535173,
0.006605175,
-0.034233414,
0.010168406,
-0.030195085,
-0.013012392,
0.0041373074,
-0.0068295263,
0.032174658,
0.008564952,
-0.028004358,
-0.016509637,
0.012669266,
0.0067569423,
0.013540278,
0.012392126,
0.003314135,
0.017209087,
-0.023807663,
0.015242711,
0.005074305,
-0.002215472,
0.008287812,
-0.015836583,
-0.0025717951,
-0.00890148,
-0.015731005,
0.011224179,
-0.008809099,
-0.017261876,
-0.0068097305,
0.004830158,
0.024863435,
-0.02590601,
-0.008842092,
0.033441585,
-0.007977678,
0.0044375425,
0.01719589,
-0.16586182,
0.008690325,
0.027106952,
0.015599034,
0.02145857,
0.0038898606,
0.003929452,
0.004800464,
-0.018185677,
0.009792287,
0.017499425,
0.011573902,
-0.010188201,
-0.0022979542,
-0.0032679448,
0.0056714765,
-0.003685305,
0.009462358,
0.024493914,
-0.010933841,
0.049278166,
-0.021009866,
0.0030254473,
-0.037796646,
-0.009831878,
0.00982528,
-0.008611142,
0.021841288,
-0.009891266,
-0.015071148,
-0.022936651,
0.0044738348,
0.036318563,
-0.006747044,
0.010650102,
0.012425119,
0.003982241,
-0.01200281,
-0.012616478,
0.011837846,
0.019927701,
0.015836583,
0.030142296,
-0.00089328224,
-0.024163986,
0.035790678,
0.02679022,
-0.009990244,
-0.021379387,
0.01223376,
0.025232956,
-0.003685305,
-0.0051798825,
-0.0065952768,
0.010854658,
0.018238464,
0.0022765088,
0.0046519963,
0.00068336504,
-0.023253383,
-0.021841288,
-0.023596508,
0.023622902,
-0.0028439863,
0.008776106,
-0.028796187,
-0.022316385,
-0.012266753,
-0.0019944196,
0.04273238,
-0.04885586,
-0.009534943,
-0.014503671,
-0.016945144,
0.017407045,
0.041703,
-0.0050215167,
-0.00014156009,
0.011105404,
-0.027450077,
-0.012246957,
0.01413415,
-0.01983532,
0.020191643,
0.0054768184,
0.012161176,
-0.003286091,
-0.00035735415,
0.010168406,
-0.013309328,
0.010142012,
-0.0139493905,
0.0067008543,
-0.016918749,
-0.0034411575,
0.01654923,
0.009218211,
0.0023259982,
-0.000014395722,
-0.0059255213,
0.007891897,
-0.00021197926,
-0.019439405,
0.0061795665,
0.028611427,
-0.013414905,
-0.027133346,
-0.008993859,
0.043735363,
0.0010582467,
-0.02679022,
0.012062198,
0.0064633056,
0.0060640913,
0.009244605,
0.022382371,
-0.0050875023,
-0.013197153,
-0.0039195544,
0.0029462643,
0.055797562,
-0.008868487,
-0.013282934,
0.03642414,
-0.013137765,
-0.015862977,
-0.111595124,
-0.0005798499,
0.024771055,
-0.0043352647,
-0.011923627,
0.01255709,
-0.0016092277,
0.0055494024,
-0.0021478366,
0.011976416,
-0.011877437,
-0.013500687,
0.0019333828,
-0.005463621,
0.024942618,
-0.01357987,
0.020587558,
-0.021960061,
-0.042072523,
0.037136786,
-0.009000458,
-0.009468957,
0.025985193,
-0.009046648,
-0.0017090313,
-0.01376463,
-0.0077401297,
0.017670987,
-0.0060772886,
0.011534311,
-0.009007056,
-0.0048829466,
0.0034774498,
0.007852306,
-0.0055230083,
-0.0025569482,
-0.0020917486,
-0.0010178303,
0.02428276,
-0.028479455,
0.0007076973,
0.022791483,
0.009422767,
0.022118427,
0.033995863,
-0.029746382,
-0.01723548,
0.020099264,
0.014028573,
0.011204382,
-0.003837072,
-0.02906013,
-0.03225384,
-0.003906357,
0.010419152,
-0.021445373,
0.013566673,
0.011877437,
-0.0068889135,
0.016865961,
-0.0037479913,
-0.010161808,
-0.007944685,
0.017723776,
0.006067391,
-0.027054163,
0.008030468,
-0.0054009347,
0.0051369914,
-0.032359418,
0.008413184,
-0.020957079,
-0.021036262,
-0.013025589,
-0.047905665,
0.028585032,
-0.0076807425,
-0.026196348,
0.01895111,
-0.01538788,
-0.017024327,
-0.00088503404,
-0.005245868,
-0.028980946,
0.033019274,
0.0108678555,
0.0010747431,
-0.011884036,
0.00044004255,
-0.03367913,
0.0047476757,
0.03998737,
-0.03396947,
0.0053448468,
0.0113033615,
0.024797449,
0.011884036,
-0.026724234,
0.019690152,
0.034946058,
-0.0053118537,
-0.018964307,
-0.057117276,
0.0154010765,
0.023438143,
-0.009541541,
-0.0012636273,
-0.002604788,
0.04009295,
0.008815697,
0.0037776849,
0.02182809,
-0.018753154,
-0.0058364407,
-0.0037149985,
-0.01955818,
-0.03230663,
-0.0126428725,
0.004421046,
0.011778459,
0.025523294,
0.018660774,
-0.014886388,
0.018159281,
0.011969817,
0.044843923,
-0.016971538,
0.009323788,
-0.008782705,
0.043576997,
-0.03341519,
0.016536033,
0.0108348625,
-0.014516868,
-0.0022715598,
-0.01130996,
-0.031831533,
0.013032188,
0.0053184526,
0.021379387,
0.0029446147,
0.027872385,
0.004203293,
-0.03740073,
0.024124395,
-0.026103968,
0.0021890777,
-0.012128183,
-0.037664674,
0.042468436,
-0.005806747,
-0.0052062767,
0.0103993565,
-0.009752695,
-0.0033685733,
-0.039169148,
-0.023688888,
0.004612405,
0.010049632,
-0.017618198,
-0.005942018,
-0.03513082,
0.030617394,
-0.008729916,
0.013896601,
0.007918292,
0.020376403,
-0.0016364469,
-0.008116249,
-0.0060179015,
0.010597314,
-0.01701113,
0.014398093,
-0.0057473597,
-0.0008347199,
0.006222457,
0.0067074527,
-0.007957883,
-0.012398724,
0.0236361,
-0.004523324,
0.0006289268,
-0.0015176726,
-0.017512621,
-0.032333024,
0.009442562,
-0.019478997,
0.004945633,
-0.030802153,
0.019439405,
-0.00007562587,
0.0044144476,
-0.00012413571,
0.023490932,
-0.011065813,
0.025760842,
0.004945633,
0.033916682,
0.0139493905,
-0.02261992,
0.010346567,
0.0342862,
0.0070142867,
0.013355519,
-0.013461095,
-0.005156787,
-0.0049555306,
0.022857469,
-0.024955815,
-0.020152051,
-0.0171431,
0.019729743,
0.004454039,
0.024441127,
-0.004421046,
0.0058892295,
-0.016179709,
0.0010664948,
0.009165422,
-0.01098663,
-0.0011671232,
0.030353451,
0.018687168,
0.028717004,
0.00020383415,
0.009172021,
0.014978768,
0.0010005091,
0.012154577,
-0.033547163,
0.037928615,
0.00861774,
-0.015519851,
0.0005410832,
-0.029324073,
-0.005691272,
-0.010669897,
-0.013645856,
0.014833599,
0.012180972,
-0.011362748,
0.07569887,
0.030485421,
-0.022171216,
0.017908536,
0.007489384,
0.020270826,
-0.0019383318,
0.022210808,
0.013065181,
-0.027819598,
-0.007364011,
-0.004176899,
0.002118143,
-0.022580327,
-0.02498221,
0.035210002,
0.011428734,
-0.002622934,
0.011732268,
-0.001459935,
0.026697839,
0.0046816897,
0.016575623,
-0.023622902,
-0.021946864,
-0.018673971,
0.032517783,
0.013243343,
0.0072518354,
-0.024098,
-0.011884036,
-0.010643504,
-0.0105445245,
-0.021339795,
0.024045212,
-0.034787692,
-0.019544983,
-0.031620376,
0.0074959826,
-0.017169496,
0.01098663,
0.024190381,
-0.03138283,
-0.020191643,
-0.024823844,
-0.008960866,
-0.012095191,
-0.01649644,
-0.023517326
] |
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states. Previous studies have functionally implicated the NMDA receptor-NO pathway and the downstream second messenger, cGMP, in these processes. Because cGMP can broadly influence diverse ion-channels, kinases, and phosphodiesterases, pre- as well as post-synaptically, the precise identity of cGMP targets mediating spinal LTP, their mechanisms of action, and their locus in the spinal circuitry | [
-0.010878362,
0.005439181,
0.024232991,
-0.019081825,
-0.026192818,
0.025146695,
-0.017121999,
-0.0042109787,
-0.012904399,
-0.028258583,
0.027490541,
0.017333873,
-0.027013827,
-0.00028573908,
0.0031830631,
0.0057735434,
0.043036733,
-0.00011141962,
0.006154253,
0.0012083391,
-0.013904176,
0.008911914,
0.005783475,
-0.02562341,
0.010977678,
0.016711494,
-0.006991814,
-0.045605697,
-0.034455873,
-0.011414666,
0.005680849,
0.0134539455,
-0.0060979743,
-0.0003780198,
0.0030771266,
-0.011712613,
-0.0044062994,
-0.022326134,
-0.001731401,
0.0015443567,
0.015268109,
-0.001738022,
0.007879033,
-0.014288195,
0.0061708055,
-0.007210308,
0.0065978626,
-0.00079783483,
-0.0063893,
0.012308506,
0.02204805,
0.010653247,
-0.029688725,
-0.0007775579,
0.0095475335,
-0.014592763,
0.032549012,
0.0055815335,
0.03270792,
-0.02639145,
-0.018644838,
0.021544851,
-0.0231339,
0.0064257155,
-0.0068461513,
-0.00734935,
-0.0024514387,
0.02595446,
0.033184633,
-0.009057578,
0.01885671,
0.0315691,
0.003668054,
-0.020564938,
0.020657632,
-0.0051942025,
-0.008733147,
-0.015837518,
-0.040361837,
0.02627227,
0.024828885,
-0.02293527,
-0.015638888,
0.03694538,
-0.0058629275,
-0.02223344,
0.006998435,
0.0018687875,
0.013195725,
-0.014804636,
0.006601173,
0.023570888,
0.021293253,
0.0052571027,
0.011242519,
0.011593434,
-0.012427685,
0.025835283,
-0.03151613,
-0.018830227,
-0.016896883,
-0.0051081292,
-0.012924262,
-0.023769518,
-0.016857158,
-0.0005189237,
0.010183154,
-0.005919206,
0.028152645,
0.0083954735,
-0.030006535,
0.01738684,
-0.017532503,
-0.03029786,
-0.006303226,
0.008951641,
0.031992845,
-0.0030787818,
0.004005727,
-0.022776363,
0.010249364,
-0.0039792424,
0.0037905432,
-0.007879033,
0.028708812,
0.028364519,
-0.0018869953,
0.006971951,
-0.028788265,
0.0038104062,
-0.015546192,
0.0007622468,
0.017744377,
0.022061292,
-0.031966362,
0.018287301,
0.0037971642,
-0.013811481,
-0.02627227,
-0.04205682,
0.014235227,
0.0231339,
-0.040759098,
0.027517026,
0.00007696955,
0.031277776,
0.0009865344,
0.018300543,
0.028046709,
0.005207445,
0.00447251,
-0.022736637,
-0.00932904,
-0.0010932985,
-0.016274506,
0.005836443,
0.0009054267,
0.014738427,
0.0015153897,
-0.025067242,
-0.0051875818,
-0.028073194,
0.010494342,
-0.008541136,
0.018221091,
0.011699371,
0.014963541,
-0.0055451174,
0.015427014,
-0.018419722,
-0.004883014,
0.023875456,
-0.021743482,
0.017943008,
-0.024193266,
0.010236122,
-0.0044394047,
0.011937728,
-0.009309176,
-0.01540053,
-0.014844363,
-0.007521497,
0.017214693,
-0.0014665595,
-0.008600726,
-0.019849867,
0.017651683,
-0.02473619,
-0.007183824,
-0.02709328,
-0.0086868,
0.00779958,
-0.02134622,
-0.025808798,
-0.64028066,
-0.021372704,
0.028258583,
-0.01763844,
0.0025904803,
0.031913392,
-0.0076075704,
-0.0006029281,
-0.014116049,
0.039328955,
-0.016420169,
0.0414212,
0.015215141,
-0.021558093,
-0.03175449,
-0.02844397,
-0.022074534,
0.0021319736,
0.011189551,
0.0039031007,
-0.0028271824,
-0.01514893,
0.003476044,
0.021902388,
0.025782315,
0.020114707,
0.014182259,
-0.021942113,
-0.012480653,
0.034535322,
-0.03130426,
0.016817432,
-0.0012248916,
0.005104819,
0.04640022,
0.004422852,
-0.013063304,
0.029662242,
-0.0006931397,
0.037792873,
-0.036627572,
-0.016115602,
0.022193713,
0.008567621,
-0.019346667,
0.008037938,
0.009031093,
-0.0187905,
-0.0054987706,
-0.019518815,
0.044149067,
-0.0047174883,
-0.01917452,
0.013526777,
-0.0017711271,
-0.00024559905,
0.026709259,
-0.008302779,
0.0006484477,
0.025345325,
-0.0031847183,
0.0127587365,
-0.008031317,
-0.017029304,
-0.012056907,
-0.0076208124,
-0.028285066,
-0.022869058,
0.011394803,
0.018459449,
0.0126527995,
0.026086882,
0.00062610174,
-0.010553932,
0.0114742555,
0.024246234,
-0.0061443215,
-0.00013635196,
-0.013540018,
0.0010246054,
-0.024775917,
0.010487721,
-0.030695124,
0.0042804996,
0.029847631,
0.015837518,
-0.012864673,
0.006250258,
0.015559435,
-0.0025673066,
0.0010262606,
-0.016724737,
-0.039196532,
-0.033237603,
-0.025649894,
0.014658974,
0.002178321,
0.010361921,
0.013745271,
-0.0047042463,
-0.012884536,
0.009852102,
-0.0022958443,
-0.012229053,
0.032390106,
-0.008382232,
-0.03596547,
0.022855816,
0.04277189,
-0.016420169,
0.0016966405,
-0.013732029,
0.0003505011,
-0.00389979,
0.018168123,
-0.026153091,
0.029000137,
-0.010275848,
-0.015095962,
-0.020790054,
-0.005316692,
0.002613654,
-0.006177427,
-0.014963541,
0.006978572,
0.01917452,
-0.00881922,
0.0038402008,
0.017320631,
-0.00091949635,
-0.00837561,
0.0044360943,
0.018101912,
-0.006237016,
-0.0011073683,
0.00389979,
0.037077803,
0.0012166153,
0.019412877,
-0.04645319,
-0.041341748,
-0.015307835,
-0.019743929,
-0.0008897017,
-0.0010444684,
-0.00971306,
-0.020538453,
-0.001610567,
0.008997988,
-0.023729794,
0.0011785444,
-0.025914734,
-0.0041447687,
0.009110546,
0.029927082,
-0.0030903686,
0.0042540156,
-0.016645284,
-0.019148037,
-0.02677547,
-0.004330158,
0.0064389575,
-0.033052213,
0.023306048,
-0.0347472,
-0.023504678,
0.012811705,
0.021187315,
0.026921133,
-0.04261299,
0.0027725587,
-0.030562703,
-0.015956696,
0.027411088,
-0.009110546,
0.007534739,
0.022683669,
-0.021253526,
0.020697359,
0.0045155464,
0.0042341524,
0.0033883152,
-0.0076340544,
-0.0058331327,
0.035674144,
0.00033518995,
0.01131535,
0.007720128,
0.021637546,
0.022259923,
-0.020459002,
0.035038523,
-0.030377313,
0.014658974,
-0.022869058,
-0.018499175,
0.019704204,
0.013003714,
-0.01079891,
0.019916076,
0.0061377003,
-0.020286854,
-0.0075810864,
-0.0078326855,
0.011447771,
-0.036786474,
-0.012255537,
-0.026086882,
0.0027907668,
-0.0076406756,
-0.005611328,
0.0020028634,
-0.008700041,
-0.01616857,
0.009031093,
0.014274954,
-0.013473808,
0.007329487,
-0.011110098,
-0.025504231,
0.015625644,
-0.0096799545,
0.029450368,
0.012434306,
-0.0044791307,
0.0512733,
-0.017121999,
0.02396815,
-0.0061244583,
-0.013354629,
-0.010176532,
0.02575583,
-0.004287121,
0.006730283,
0.001105713,
0.014089565,
0.012983852,
0.00024642667,
0.04581757,
0.017042547,
0.00504854,
0.018631596,
-0.0049028774,
0.0027675931,
0.018221091,
-0.0013448979,
0.015003268,
0.007839306,
-0.0063893,
0.012050286,
-0.014910573,
0.0053001395,
-0.013268556,
-0.0019565162,
0.0014963541,
-0.015771307,
0.0299006,
0.023941666,
0.050823074,
0.029476853,
-0.0073162448,
-0.017797345,
0.019969044,
-0.018605111,
0.0061410107,
0.008574242,
0.0038898587,
0.011341834,
-0.014314679,
-0.0067203515,
-0.011593434,
0.005088266,
-0.0009774305,
-0.024246234,
0.018459449,
-0.0023570887,
0.009342282,
0.011408045,
0.0084352,
0.017943008,
-0.029370915,
-0.052226733,
0.037236705,
0.009216482,
-0.016075876,
-0.013573124,
-0.036839444,
0.015241625,
-0.0007614191,
-0.004992261,
0.0061972896,
0.01738684,
0.0026268961,
-0.016592316,
0.003482665,
-0.027384605,
0.040044025,
-0.003909722,
0.01942612,
0.0002807733,
0.0084352,
0.007355971,
-0.021624304,
-0.018313786,
0.021836177,
0.007826065,
-0.0209622,
-0.0337408,
-0.0010146737,
-0.019214246,
0.03898466,
0.008481547,
-0.0037243327,
-0.03252253,
0.008143874,
0.018459449,
0.0022792916,
0.010666489,
0.026510628,
-0.011394803,
-0.02218047,
-0.04060019,
-0.0013010335,
-0.002428265,
0.028232098,
0.015612403,
0.0076340544,
0.0073030028,
-0.01591697,
-0.019333426,
-0.0037673695,
-0.0061277687,
0.02281609,
-0.012295264,
-0.003322105,
0.010812152,
-0.0019763792,
0.011070373,
0.0034363177,
0.006078111,
-0.00091949635,
-0.0038368904,
0.012242296,
-0.030509735,
0.018446207,
0.023186868,
0.021200558,
0.028338034,
0.008309401,
-0.01591697,
-0.0068593933,
0.027569994,
0.016896883,
-0.012507137,
-0.007197066,
0.008726525,
0.0004796113,
0.0024332306,
-0.03572711,
-0.0209622,
-0.0031466475,
0.030059503,
0.014063081,
0.025040759,
0.0052703447,
0.0038402008,
0.037686937,
0.0033055523,
-0.0073692133,
-0.021624304,
0.017691407,
0.013533398,
-0.0003647777,
0.004485752,
0.02587501,
-0.008666936,
-0.007746612,
-0.023597373,
0.013943902,
0.0061443215,
0.010011006,
-0.005965553,
0.0020243817,
0.0058629275,
-0.008858946,
-0.010507585,
0.00036953657,
-0.026643049,
0.0041447687,
-0.007322866,
-0.014844363,
0.026298756,
-0.0014930436,
-0.023915183,
-0.007978348,
-0.015691856,
-0.035886016,
-0.0021170762,
0.031675037,
0.005399455,
0.029000137,
-0.007932001,
-0.01770465,
0.04467875,
-0.027702415,
-0.01099092,
-0.011931106,
-0.0212138,
0.032813855,
0.015903728,
0.029503336,
-0.017625198,
-0.021452157,
-0.019320183,
0.026245786,
-0.03270792,
0.019969044,
-0.01028909,
-0.010024249,
-0.005144545,
0.025093727,
0.025146695,
-0.010494342,
-0.019783655,
-0.003426386,
-0.03853443,
-0.027490541,
-0.03803123,
-0.023041205,
-0.0015021475,
0.03111887,
0.016142085,
0.011739097,
-0.021849418,
0.0011313695,
-0.022405585,
-0.007786338,
0.0013200691,
0.022458553,
0.029106075,
-0.004939293,
0.025504231,
0.024643496,
-0.0011942694,
-0.0034462493,
-0.0064091627,
0.016075876,
-0.005826512,
-0.017532503,
-0.0060681794,
0.0050981976,
-0.0013804861,
-0.016287748,
-0.00039726216,
-0.013149378,
0.026060397,
0.010004385,
-0.025292357,
-0.024709707,
0.01348705,
-0.017784102,
0.011037267,
-0.0065515153,
-0.008925157,
-0.008753009,
0.0126263155,
-0.016380442,
0.0034363177,
0.050770104,
-0.027172731,
-0.018538902,
0.00021766656,
-0.00059630704,
0.015811034,
0.0029662242,
-0.00064058526,
-0.030271377,
0.0037342643,
-0.0049624667,
-0.02421975,
-0.017439809,
-0.014460343,
0.011269003,
0.011792066,
0.020101465,
-0.007574465,
0.010494342,
0.009302556,
0.011434529,
0.0044956836,
-0.012447548,
0.0037475063,
-0.03419103,
0.040706128,
0.0030787818,
-0.008746388,
0.013943902,
-0.020061739,
0.0034793543,
0.038322557,
-0.008739768,
-0.031463165,
0.01041489,
-0.026629807,
-0.028152645,
0.010851878,
-0.020061739,
0.0051809605,
-0.040759098,
-0.0024812333,
0.012328369,
0.0034992176,
-0.00293974,
-0.011772202,
0.009825617,
-0.023570888,
0.032496046,
-0.00824319,
0.024524318,
-0.022842575,
-0.008726525,
-0.009580639,
0.03170152,
-0.010971056,
-0.0021319736,
0.0016701564,
0.0042209104,
0.004787009,
-0.009858723,
0.0026600012,
-0.021399189,
0.021756724,
-0.03630976,
-0.024709707,
-0.022908784,
-0.00044567848,
-0.022339376,
-0.026245786,
0.017347114,
0.008845704,
-0.014778152,
0.031330742,
-0.048916213,
-0.00517765,
0.03885224,
-0.001188476,
0.029503336,
-0.016300991,
0.014327922,
0.0050849556,
0.005419318,
-0.000509406,
-0.008905293,
-0.002383573,
-0.014367648,
0.028920686,
0.010368543,
-0.008997988,
-0.017280905,
0.00062403263,
0.0149503,
-0.00040284867,
-0.023769518,
0.017916523,
0.000026225509,
-0.011017404,
-0.0044195415,
-0.011447771,
-0.0019830002,
0.016724737,
-0.022776363,
-0.0029629136,
-0.000936049,
-0.020538453,
-0.019916076,
0.030748092,
0.0014036596,
0.033661347,
-0.00022139089,
-0.006160874,
-0.01591697,
-0.0014715253,
0.013467187,
0.007786338,
-0.0121694645,
0.033052213,
-0.005485528,
0.0024216438,
-0.008872189,
0.020538453,
-0.007177203,
-0.007839306,
0.0029860872,
0.04269244,
-0.0033187943,
-0.0051610977,
0.029450368,
-0.030774575,
-0.006217153,
-0.03514446,
0.0015526329,
-0.013076546,
-0.021134347,
-0.0018985821,
0.008223327,
0.00046678304,
-0.016102359,
0.0008681833,
-0.01808867,
-0.01246079,
-0.028788265,
0.005598086,
0.008494789,
-0.033528928,
-0.0030787818,
-0.016102359,
0.0036018435,
0.029000137,
0.011739097,
-0.015334319,
0.0035190806,
0.021452157,
-0.015572676,
0.021041652,
0.016963094,
0.014195501,
-0.021995082,
0.0045718253,
-0.00491943,
-0.016843915,
0.014010112,
-0.017439809,
-0.024722949,
0.025358567,
0.017943008,
0.006316468,
-0.008256432,
-0.00555836,
0.016314233,
0.019359909,
-0.0023355705,
0.0017595403,
-0.007879033,
-0.0045354096,
-0.00064720627,
-0.011772202,
0.016804188,
-0.03048325,
-0.010408268,
-0.020247128,
-0.0045652045,
0.025133453,
-0.025027515,
-0.016208297,
-0.028338034,
-0.012440926,
-0.011096857,
-0.0004262292,
0.016618801,
-0.0020028634,
-0.03654812,
0.018578626,
0.008653694,
-0.005190892,
-0.0053464863,
0.0021303184,
-0.004399678,
-0.00078169606,
-0.012566727,
0.005164408,
0.0014351095,
-0.028046709,
-0.038110685,
-0.0086868,
-0.046426706,
0.03246956,
0.0027510405,
-0.0146987,
-0.009620366,
-0.0031631999,
-0.034879617,
-0.018697806,
-0.0043765046,
-0.009501187,
0.029185526,
0.031489648,
-0.011964212,
-0.021955356,
0.018869953,
0.018115155,
-0.0024084018,
-0.00466452,
0.017042547,
-0.009156893,
0.031410195,
0.026060397,
-0.010898225,
-0.008938398,
0.032496046,
-0.010136806,
0.020538453,
0.016949853,
-0.012480653,
-0.00009388422,
0.011368318,
0.00012342025,
-0.002913256,
0.008508031,
0.0066806255,
-0.038507946,
0.02625903,
0.012659421,
0.0048035616,
-0.0026682776,
-0.0021634235,
0.020684116,
0.007773096,
0.012374716,
-0.018485932,
-0.014566279,
0.017598713,
-0.006971951,
0.035647657,
0.018949404,
-0.007826065,
0.00076969544,
0.009832239,
-0.009878586,
-0.039275985,
-0.019015616,
-0.024232991,
0.0050518503,
0.008845704,
-0.011931106,
0.0044261627,
0.017611956,
0.01424847,
-0.033528928,
-0.009156893,
-0.01789004,
0.00907744,
-0.027331637,
0.011573571,
0.01578455,
-0.020975443,
-0.013890933,
0.00837561,
-0.001961482,
-0.015837518,
-0.01795625,
0.0041944264,
-0.027305152,
0.0015857382,
0.017717892,
-0.008931777,
-0.0015857382,
-0.036733508,
-0.009388629,
-0.022789607,
0.018750774,
0.17394786,
-0.007812822,
-0.014672216,
0.0062469477,
-0.005707333,
0.010587037,
0.022273164,
0.0027907668,
-0.017002821,
-0.0020409343,
0.040918004,
0.012672663,
0.015427014,
-0.0046347254,
-0.0005979623,
-0.017267661,
-0.010030869,
-0.017837072,
-0.0061641843,
-0.01981014,
0.020935716,
0.014990025,
0.0209622,
0.01003749,
0.034879617,
0.018075429,
-0.018711047,
-0.012440926,
0.037581,
0.0050650924,
-0.01898913,
0.03265495,
0.018141638,
-0.010474479,
0.007753233,
0.009732923,
0.0015758065,
-0.029847631,
0.017055789,
0.0029182215,
0.006160874,
0.008633831,
-0.0061377003,
-0.004118284,
-0.013586366,
0.0019250662,
0.002019416,
-0.015201898,
-0.016764464,
0.025848525,
-0.033025727,
-0.010024249,
0.017201452,
0.022789607,
0.0017264351,
-0.0039031007,
0.0066607622,
0.017969491,
0.00015104239,
0.019863108,
-0.02587501,
0.0006252741,
-0.0028652532,
0.010573794,
-0.0008077664,
0.008521274,
-0.0034396283,
0.002019416,
0.011686129,
-0.03803123,
0.013076546,
-0.013268556,
-0.015069478,
0.010183154,
-0.02204805,
-0.0030225029,
0.04563218,
-0.0009815686,
0.010812152,
0.011461013,
0.009315798,
-0.008991367,
-0.013745271,
-0.005657675,
-0.01246079,
-0.014261711,
0.018697806,
0.007461908,
-0.016724737,
0.014619247,
0.013394356,
-0.0026600012,
-0.013043441,
-0.0060416954,
0.01016329,
-0.013705544,
0.0031085764,
-0.026417933,
-0.009885207,
-0.00021125242,
-0.03061567,
0.0848552,
0.020366307,
0.010732699,
-0.018168123,
-0.00041133186,
0.0018737531,
-0.0019283767,
0.0102427425,
-0.0086868,
0.007561223,
0.0017297457,
0.016883641,
-0.016989578,
-0.015797792,
0.002785801,
0.018750774,
-0.022776363,
0.009574018,
0.012692526,
-0.012666042,
-0.021359462,
-0.019757172,
0.017863555,
0.0049757087,
0.014102806,
-0.031966362,
-0.008441821,
0.013533398,
-0.028602876,
0.006422405,
-0.0038170272,
-0.004389747,
0.00888543,
-0.018499175,
-0.0034429387,
0.013334767,
-0.0050584716,
0.0070712664,
0.027172731,
-0.005055161,
-0.015943455,
0.013970386,
0.003860064,
0.007687023,
0.006952088,
-0.0007742474,
0.016645284,
-0.017466294,
0.0024779227,
-0.00071714097,
-0.005684159,
0.017227937,
-0.00022863265,
0.035886016,
-0.014155775,
-0.022802848,
-0.02134622,
-0.008104148,
0.013043441,
-0.015003268,
-0.011970833,
0.0061145267,
-0.003252584,
0.0031913393,
-0.00067162135,
-0.16610855,
0.009375387,
0.011699371,
-0.022326134,
0.014526553,
0.035859533,
0.008839083,
0.014327922,
-0.003860064,
0.020564938,
0.007534739,
0.00077631645,
-0.022140745,
-0.044784687,
0.01207677,
0.019836623,
-0.009037714,
0.017029304,
0.0025540646,
0.008739768,
-0.014857605,
-0.014116049,
0.024511075,
-0.01917452,
-0.0051842714,
0.035700627,
-0.020922475,
0.013705544,
-0.0051114396,
-0.019664478,
-0.012387958,
-0.0003869168,
0.020856263,
-0.0027874561,
0.034455873,
0.016711494,
-0.0039825533,
-0.02709328,
-0.0054921494,
0.041580107,
0.035382815,
0.020220645,
0.0039991057,
0.011871518,
-0.008494789,
-0.00008079733,
0.012447548,
-0.011381561,
-0.0015484948,
-0.008249811,
0.011235898,
0.0030787818,
0.011355077,
0.007183824,
0.026431175,
0.019664478,
0.013758513,
0.0057040225,
-0.0045023044,
-0.009448218,
0.0016900194,
-0.016910126,
0.008104148,
0.012447548,
0.0079386225,
-0.03736913,
0.0059854165,
-0.0061840476,
-0.019399635,
0.011229277,
-0.025570441,
-0.012447548,
0.013705544,
-0.019757172,
0.013301661,
0.019333426,
0.0145530375,
0.011964212,
0.0046049305,
0.01067311,
-0.00977927,
0.0036217067,
-0.014645732,
-0.02523939,
-0.018552143,
0.012639558,
0.022259923,
0.034853134,
0.025212904,
-0.0097064385,
0.0079651065,
-0.025570441,
-0.003502528,
-0.013665819,
0.02844397,
-0.00088473596,
0.004621483,
0.0047903196,
0.0046446566,
0.018247575,
0.020154433,
0.016075876,
0.00020690738,
0.004505615,
0.0034164547,
0.012030423,
-0.02958279,
0.009487945,
-0.0074552866,
0.0066111046,
-0.009613744,
-0.010500963,
0.0066508306,
0.016075876,
0.009600502,
0.014791395,
0.009057578,
-0.006359505,
0.01675122,
0.0038567535,
0.06472725,
-0.009699818,
0.016300991,
0.019770414,
0.001713193,
-0.031357225,
-0.13422164,
-0.03699835,
0.01514893,
0.023041205,
-0.011672886,
0.019055342,
0.0016908471,
0.026417933,
-0.0042242208,
0.018168123,
-0.029370915,
-0.01668501,
0.013314904,
0.00389979,
-0.0059986585,
-0.01438089,
0.00798497,
0.0040818686,
-0.02498779,
0.032893308,
-0.0059291376,
-0.008282916,
-0.005541807,
-0.008441821,
-0.0007233482,
-0.0014806292,
-0.026206061,
0.023584131,
-0.002736143,
-0.013056683,
0.029053107,
-0.0058563063,
0.015665371,
0.008825841,
-0.014288195,
-0.020273613,
0.014341164,
-0.013301661,
0.03879927,
0.0059158956,
-0.0027692483,
0.010196395,
0.027000586,
0.0068792566,
0.0032095471,
-0.015281351,
-0.012639558,
0.012301885,
0.027172731,
-0.014778152,
-0.019823382,
-0.025901493,
-0.024285961,
0.014990025,
0.009593881,
-0.0059026536,
0.00040760753,
0.026364965,
-0.013427461,
0.0017496088,
0.0017363667,
-0.0045718253,
0.003502528,
-0.014049838,
0.016592316,
-0.0073956973,
-0.027331637,
-0.060436815,
0.023848971,
-0.006498547,
-0.0027742141,
-0.011792066,
-0.009501187,
-0.0058000274,
-0.040494256,
0.019201005,
-0.01156695,
-0.018896436,
0.013506914,
0.012738873,
-0.026696017,
-0.009302556,
0.026351724,
-0.0035190806,
-0.0023355705,
0.02243207,
-0.0052107554,
0.009302556,
0.0000021660617,
-0.008190221,
-0.02365034,
0.00536966,
0.0047009354,
0.0073824553,
-0.0039395164,
-0.0011528879,
-0.014831121,
0.019637993,
0.0231339,
0.021783208,
-0.01890968,
-0.014407374,
-0.0479363,
0.011845034,
-0.0012679284,
-0.011421287,
0.012242296,
-0.012176085,
0.023213353,
-0.0063263997,
-0.0065978626,
-0.008812599,
-0.031065902,
0.015241625,
0.014235227,
-0.0067203515,
-0.035647657,
-0.01706903,
0.029264979,
-0.009772649,
0.0072963815,
0.02051197,
-0.01808867,
-0.016287748,
-0.007355971,
0.039832152,
-0.011573571,
0.0062800525,
-0.029132558,
0.012997094,
-0.01616857,
0.009567397,
0.0012133048,
-0.038269587,
0.006952088,
-0.0011297143,
-0.02523939,
-0.008640452,
0.0040090373,
0.023994634,
0.024696464,
0.04060019,
-0.027940772,
-0.018684564,
-0.006203911,
-0.023041205,
0.009044335,
-0.01693661,
-0.039064113,
0.010176532,
-0.003909722,
-0.007600949,
0.02039279,
0.0015460119,
0.010110322,
-0.039090596,
-0.031780973,
0.0065548257,
0.000538373,
0.0055914647,
-0.009070819,
-0.003176442,
0.020114707,
0.0024199886,
0.024749432,
-0.007746612,
-0.0070712664,
-0.016340718,
-0.03297276,
0.013202346,
-0.008647073,
-0.0092231035,
-0.022167228,
-0.013089788,
0.013155999,
0.018313786,
-0.0019763792,
0.007011677,
0.014817879,
-0.019359909,
-0.018816985,
-0.0076075704,
0.025292357,
-0.0005578223,
-0.020816537,
0.012771978,
0.019585025,
0.0025077173,
0.004896256,
0.034429386,
-0.027490541,
-0.0009418424,
0.012699147,
-0.0053464863,
0.022061292,
0.01054731,
0.020525211,
0.023306048,
-0.003158234,
-0.0027493853,
0.002037624,
0.00939525,
-0.00075397047,
0.015479982,
0.008329263,
-0.031780973,
0.002984432,
0.022723395,
-0.06001307,
-0.027914288,
-0.0055914647,
-0.0036382594,
0.024232991,
0.013208967,
-0.0033121733,
-0.00082721567,
-0.020882748,
0.011739097,
-0.0051610977,
-0.01546674,
-0.01016329,
0.01367906,
0.029000137,
0.0029562926,
0.0005660986,
-0.014354406,
0.034429386,
-0.011487497,
0.028126162,
-0.007362592,
0.023862213,
-0.0039957953,
-0.011096857,
0.008104148,
-0.029662242,
-0.003118508,
-0.00020276922,
-0.025861766,
-0.018313786,
0.01942612,
0.015387287,
0.07871088,
-0.00047257644,
-0.009746165,
-0.0030638843,
-0.0032178236,
0.020684116,
-0.018618353,
0.017479535,
0.0008280433,
-0.044784687,
0.012646179,
-0.00549546,
0.025596926,
-0.032363623,
-0.00070514035,
0.001233168,
0.014235227,
0.024961306,
-0.0016246367,
-0.023676824,
0.013301661,
-0.014804636,
-0.0028354586,
0.0017545746,
-0.021359462,
0.01789004,
0.03803123,
-0.011262382,
0.0015360804,
-0.007826065,
-0.00009284968,
0.00064182666,
-0.04014996,
0.00575368,
-0.005488839,
-0.015996423,
-0.012507137,
-0.0320723,
0.017439809,
0.019730687,
-0.001802577,
0.02365034,
-0.015334319,
-0.02032658,
-0.0011710958,
0.009242966,
-0.008832462,
-0.0126527995,
-0.020617906
] |
The Sleeping Beauty (SB) transposon mutagenesis system is a powerful tool that facilitates the discovery of mutations that accelerate tumorigenesis. In this study, we sought to identify mutations that cooperate with MYC, one of the most commonly dysregulated genes in human malignancy. We performed a forward genetic screen with a mouse model of MYC-induced liver cancer using SB-mediated mutagenesis. We sequenced insertions in 63 liver tumor nodules and identified at least 16 genes/loci that contribute to accelerated tumor development. RNAi-mediated knockdown in a liver progenitor cell line further validate three of these genes | [
-0.03936851,
-0.020413302,
-0.00941685,
-0.018941708,
-0.053112388,
0.009943384,
-0.025867648,
-0.0045599155,
-0.03796442,
0.006068637,
0.013109336,
0.0017821136,
0.023910025,
0.009302093,
0.018469177,
-0.0012969264,
0.02791978,
-0.013122837,
-0.004057009,
0.007344468,
-0.015823008,
0.0035102237,
-0.0040232567,
0.0038983736,
-0.0030123796,
0.024841584,
0.01428391,
-0.05035821,
-0.027028723,
-0.001913747,
0.017213598,
-0.0007509854,
-0.015715001,
0.012954076,
-0.020480806,
-0.012130523,
0.001187232,
-0.011050454,
0.009241339,
-0.03499423,
0.012130523,
0.023856021,
-0.009653116,
0.014459422,
-0.012407291,
0.0007598453,
0.002025129,
-0.022856956,
-0.009032076,
0.011705246,
-0.010847942,
0.010753436,
-0.022424929,
-0.004222394,
-0.009842128,
0.010240403,
0.011367724,
0.023410492,
0.006315028,
-0.0067740567,
0.0076482375,
0.014067897,
-0.03575028,
0.018887704,
0.010564423,
0.023005467,
0.0076347366,
-0.0056231087,
-0.0014513425,
-0.008134268,
0.051789302,
0.023140475,
0.0067268037,
0.0044350326,
0.007148706,
-0.016835574,
-0.034400195,
0.01004464,
0.0014715939,
0.014013894,
0.017888641,
-0.017470114,
-0.017834637,
0.008114018,
0.020494306,
0.022100909,
-0.017321605,
0.019049715,
0.0015466923,
0.007965508,
0.012333036,
0.023167478,
-0.007337718,
0.015782505,
-0.028378809,
0.0051640794,
0.010739935,
0.03858546,
-0.009626114,
-0.029998913,
-0.011529735,
0.007101453,
-0.024112538,
-0.010341659,
-0.015944516,
0.0017703003,
-0.005096575,
-0.0013154901,
0.01286632,
-0.01598502,
-0.030079918,
0.039719533,
0.0062812753,
-0.022532936,
0.023126975,
-0.006946193,
-0.0011982014,
0.014985955,
-0.012468045,
-0.016120028,
0.030187925,
0.035021234,
0.012461294,
-0.024652572,
0.01676807,
-0.008951071,
-0.015080461,
-0.0016833886,
-0.012164275,
-0.023815518,
0.021061342,
0.010530671,
0.012130523,
0.00423252,
-0.023761515,
0.010132396,
-0.011320472,
-0.030835966,
-0.039476518,
-0.039314505,
-0.0017103903,
0.036830347,
-0.023937026,
-0.006649174,
-0.0045362893,
0.0071757073,
0.01238704,
0.008188272,
0.004111012,
-0.008350282,
0.0108951945,
-0.001655543,
-0.0053227143,
-0.009659866,
0.0075537316,
0.021520372,
0.0018040525,
0.016417047,
-0.018712193,
-0.028000785,
0.0080802655,
-0.0031102607,
0.021830892,
0.016403547,
0.009383098,
0.02619167,
0.02008928,
-0.010645429,
-0.0021280732,
-0.012663808,
-0.00069529435,
0.023086471,
-0.025611132,
0.031294994,
-0.0035676025,
-0.0043709036,
-0.014729439,
-0.0010522234,
0.002627605,
-0.012069769,
-0.008984823,
0.017672626,
0.03356314,
0.015350479,
-0.018253164,
-0.0022951462,
0.005852623,
-0.021250354,
0.0032891473,
-0.026704703,
-0.008343532,
0.011570238,
0.012994578,
-0.013737126,
-0.6242798,
-0.022100909,
-0.008640551,
-0.018766196,
0.008890317,
0.02366701,
0.021925397,
-0.0143514145,
-0.006230647,
0.016538555,
-0.023194479,
0.022357425,
0.029539883,
-0.01113821,
-0.021277357,
-0.012015766,
0.008897067,
-0.007013697,
0.032807093,
0.011462231,
-0.023477998,
0.008512293,
0.009821876,
0.02713673,
0.0219389,
0.015039959,
0.017659126,
-0.008060014,
-0.0092953425,
0.03375215,
-0.011246217,
0.03156501,
-0.001969438,
-0.014621432,
0.04690199,
0.0018428675,
-0.0015196906,
0.021749886,
0.013271346,
0.033185117,
-0.009700368,
-0.006338654,
0.023342988,
0.00037528173,
-0.022411428,
0.016417047,
-0.0038409948,
0.0022293297,
-0.016727567,
0.0030258803,
0.006652549,
0.020305295,
-0.0050628227,
-0.011016702,
0.0012960826,
0.005346341,
0.020642815,
-0.02715023,
0.02211441,
-0.0006569013,
0.0018648064,
0.025354616,
-0.010699432,
-0.01676807,
0.000108323315,
0.00021147833,
0.0023002091,
0.008424537,
0.014756441,
-0.0021567624,
0.029404875,
0.032213055,
-0.008195022,
0.037910417,
0.0033904037,
0.042419706,
-0.007783246,
-0.005609608,
0.002688359,
0.005589356,
0.013399605,
-0.010348409,
-0.04214969,
-0.0015686313,
0.035642274,
0.008417787,
-0.030484943,
0.01301483,
-0.0042932737,
-0.009025325,
0.025246609,
0.00642641,
-0.005484725,
-0.024382554,
-0.022330424,
0.005346341,
-0.0026039786,
0.0064534117,
0.025192605,
-0.037559394,
-0.029674891,
-0.0069090654,
-0.005005444,
-0.010550923,
0.02258694,
-0.0038679966,
-0.033428133,
-0.003543976,
0.015485487,
-0.034724213,
0.0019289355,
-0.008660803,
-0.004765804,
-0.019670755,
-0.019009212,
-0.020413302,
0.014972455,
0.0038139932,
-0.0016234785,
-0.037910417,
0.000010844197,
-0.0061563924,
-0.00058897503,
-0.01223178,
-0.0060720122,
0.022613943,
0.010199901,
-0.0030495068,
-0.007925006,
0.0019188098,
0.021439366,
-0.02808179,
0.014337914,
-0.04563291,
-0.008174771,
-0.02760926,
0.014148902,
0.011806503,
0.0067099277,
-0.020723822,
-0.03593929,
-0.003074821,
-0.009794874,
0.027190734,
-0.019360235,
-0.020170286,
-0.02118285,
-0.0060146335,
0.02574614,
0.015336978,
-0.017848138,
-0.0045126625,
-0.013210592,
0.009491105,
0.033401128,
-0.0015180031,
-0.044471834,
-0.013818131,
-0.0052484595,
-0.012690809,
0.0049615665,
0.02743375,
-0.007607735,
0.0037464888,
-0.016444048,
-0.0135818655,
0.0076414873,
0.006396033,
-0.012933824,
-0.026745206,
0.014796943,
-0.02918886,
-0.015809508,
0.003230081,
-0.013156589,
-0.001599852,
-0.026907215,
-0.011725497,
-0.00955861,
-0.0059505044,
0.0046645473,
-0.0074592256,
0.0058391225,
0.010355161,
0.039746534,
0.031403,
0.013365852,
-0.0045261635,
0.00282168,
0.032240056,
-0.013973391,
0.012576052,
-0.00026432154,
0.013629119,
-0.001982939,
-0.009801625,
0.029512882,
0.0015635685,
0.012292534,
0.016606059,
0.017996646,
-0.015417983,
0.008593298,
-0.026718203,
0.0038511206,
-0.035102237,
-0.003935501,
-0.007357969,
0.0010809127,
-0.00815452,
-0.003225018,
0.01945474,
-0.005690613,
-0.015174967,
0.018590685,
-0.003857871,
0.0038511206,
-0.017537618,
-0.0051573287,
-0.019738259,
-0.0098083755,
-0.001780426,
0.0062002703,
-0.009315594,
0.008127518,
0.010604926,
0.019684255,
0.00016633482,
0.016376544,
0.010807439,
0.000040634426,
0.010307907,
0.011219216,
0.004283148,
0.0188337,
-0.0077359932,
0.0035237246,
-9.393909e-8,
0.03026893,
-0.0028453064,
-0.0039118743,
0.00988263,
0.0051370775,
-0.01082094,
0.0053092134,
0.008255776,
0.026272675,
0.0029077479,
-0.014931952,
-0.015633997,
-0.007702241,
0.012690809,
-0.023302486,
0.009214338,
0.002055506,
-0.014796943,
0.0063285283,
0.018901205,
0.050709233,
0.015255973,
-0.0013526175,
-0.00024828926,
-0.0057648676,
-0.022046905,
-0.0052315835,
0.032186054,
0.00893757,
-0.01066568,
0.004252771,
0.007074451,
-0.022978464,
0.011833505,
0.013062083,
-0.03418418,
0.01490495,
-0.00067968393,
0.0025010344,
0.02964789,
0.020966837,
0.005896501,
-0.0024588443,
-0.043823794,
0.024355553,
0.023477998,
-0.014972455,
-0.0034798468,
-0.03812643,
-0.019616751,
0.008114018,
0.009909632,
0.013757377,
0.021547373,
-0.0035338502,
0.007864252,
-0.01474294,
-0.023856021,
0.01661956,
-0.023261983,
0.014729439,
-0.021911897,
0.0010032827,
0.004138014,
-0.004185267,
-0.025044097,
0.023153976,
-0.0027592385,
-0.010787188,
-0.0028993099,
-0.011847005,
-0.006308277,
-0.006358905,
-0.0061698933,
-0.0068516866,
-0.031403,
-0.015715001,
0.008998323,
-0.015633997,
-0.0013391166,
0.013129587,
0.011259718,
-0.03043094,
-0.041339636,
-0.0077089914,
0.01678157,
0.029836902,
0.036155306,
-0.0059302533,
0.008411036,
0.0068145595,
0.004806306,
-0.009686868,
-0.033644143,
0.032969102,
-0.024031533,
-0.008573047,
0.0034292187,
-0.001810803,
-0.01192126,
-0.015363979,
0.033995166,
0.003204767,
-0.025678637,
-0.016849075,
-0.00941685,
-0.0009079329,
0.00008274551,
0.031024978,
0.035129238,
0.021520372,
-0.011414978,
0.007384971,
0.0033549638,
0.004144764,
-0.03156501,
-0.0145134255,
0.015498988,
-0.01051042,
0.0423117,
0.03718137,
-0.022343924,
0.010834441,
0.01521547,
-0.02397753,
-0.0011298533,
0.026704703,
0.021871394,
0.019954272,
0.006450036,
0.017024586,
-0.00799251,
-0.00564336,
0.001415059,
-0.010463167,
-0.014310912,
0.024099037,
-0.025611132,
-0.025233109,
-0.017065087,
0.025624633,
0.0052282084,
-0.016700564,
-0.011043704,
0.0016800134,
-0.0037599897,
0.010213401,
-0.019805763,
0.012353288,
0.000010046539,
-0.001066568,
0.00091637095,
-0.004640921,
-0.018010149,
-0.03421118,
-0.0017652375,
0.0128798215,
-0.017213598,
-0.016849075,
0.0076212357,
0.026650699,
0.010901945,
0.016241536,
-0.0059876316,
-0.010861442,
0.033968166,
-0.017794134,
-0.008411036,
0.016106527,
-0.019198224,
0.0002670639,
-0.013500861,
0.031430002,
-0.01805065,
-0.023572503,
0.0074389745,
0.008397535,
0.0014268722,
0.0065175407,
-0.023964027,
-0.0026444811,
0.004036757,
0.0076212357,
0.018266665,
-0.0061091394,
0.0060787625,
0.024045033,
-0.020210788,
-0.019657252,
-0.016822072,
-0.016484551,
-0.025786644,
0.009430352,
0.010861442,
-0.028918844,
-0.00360473,
-0.013548113,
-0.015066961,
0.0188202,
0.004910938,
0.020683318,
0.030403938,
-0.004640921,
0.010172899,
-0.010996451,
0.021560874,
-0.016187532,
-0.01819916,
0.011955013,
-0.008134268,
-0.028675828,
0.015147965,
-0.009990637,
-0.016889576,
-0.00014397403,
0.004438408,
-0.004799556,
0.028648827,
-0.000395744,
-0.022006404,
-0.018415174,
-0.010658929,
-0.0020453804,
0.0024402805,
-0.009153584,
-0.025152104,
-0.030700957,
0.019090217,
0.011502733,
-0.030214926,
0.012042767,
-0.027676765,
-0.00957886,
0.03998955,
0.0051944563,
0.0011298533,
0.0002142207,
0.006288026,
-0.013413105,
-0.015715001,
-0.013527863,
-0.02369401,
0.0037599897,
0.00032106735,
0.05664961,
0.04047558,
0.025921652,
0.019252228,
0.024882086,
0.016214535,
0.011043704,
0.008235525,
-0.008897067,
0.017591622,
-0.0075267297,
0.012508548,
-0.0040232567,
0.015174967,
0.00090371387,
-0.009437102,
0.011043704,
0.021614878,
-0.025219608,
-0.016039023,
-0.012481546,
-0.026448186,
-0.040259566,
0.004640921,
-0.0074322238,
-0.00028836995,
-0.0329421,
-0.0010716309,
0.044444833,
0.0021095094,
0.021061342,
-0.008971322,
0.029512882,
-0.019279229,
0.022397928,
-0.0025094724,
0.019373735,
0.009281842,
-0.012103521,
0.0051978314,
-0.010604926,
0.008019512,
0.0034899726,
0.000615133,
0.0036958607,
-0.0066728005,
-0.0024402805,
0.011084206,
-0.030187925,
0.0037903667,
-0.016457548,
-0.003091697,
-0.007796747,
-0.01836117,
0.00096699916,
-0.038801473,
0.004894062,
0.010706183,
-0.027177233,
0.010496919,
0.0006670269,
0.008478541,
0.016228035,
-0.0052417093,
0.025759643,
-0.0000718288,
0.027703766,
0.02964789,
-0.006406158,
-0.017578121,
-0.008546045,
-0.016363043,
0.008215274,
0.025179105,
0.037235375,
-0.021088345,
-0.015012957,
0.02274895,
0.008458289,
-0.027838774,
-0.023802018,
0.022343924,
-0.019211724,
0.0005404563,
-0.015093963,
-0.017767133,
-0.0141219,
0.012650306,
-0.015228971,
0.008991573,
-0.002627605,
0.006372406,
-0.011030204,
0.013278097,
0.012009015,
-0.0076009845,
-0.003621606,
-0.007405222,
0.0076009845,
-0.01991377,
-0.012015766,
-0.004593668,
-0.0219659,
0.04563291,
-0.0036924854,
-0.005363217,
0.0069596935,
0.0010302844,
0.011975263,
-0.019549247,
-0.004580167,
0.044336826,
-0.015796008,
-0.012920324,
-0.0015686313,
0.0053058383,
0.016363043,
0.0028824338,
-0.0052585853,
-0.012454544,
-0.017551119,
0.0026630447,
0.027028723,
0.0065951706,
-0.015228971,
0.0059876316,
-0.0136493705,
-0.021007339,
-0.010267405,
-0.011786251,
0.009268341,
-0.06231997,
0.011786251,
-0.0075334804,
0.008525793,
0.030403938,
-0.0032975853,
0.0050121946,
0.0006463537,
0.046577968,
-0.014553928,
0.016754568,
0.013089084,
-0.002683296,
-0.017591622,
0.018955208,
-0.007236461,
-0.029215863,
0.00846504,
-0.021844393,
0.0017736756,
-0.015026458,
0.003530475,
0.008350282,
0.023883022,
-0.014081398,
0.03437319,
-0.021277357,
0.027892778,
-0.013797879,
-0.0012977702,
0.008417787,
-0.034292188,
0.021088345,
0.009477604,
0.011057205,
-0.011266468,
-0.009450602,
-0.015053459,
-0.0068888143,
-0.028756833,
-0.011597239,
-0.014135401,
0.007087952,
0.0106724305,
-0.0015390981,
-0.008120768,
-0.011354224,
-0.02493609,
0.009788124,
0.007229711,
-0.012009015,
-0.013149838,
-0.00002363969,
0.0025904777,
0.0130080795,
-0.037883416,
0.010355161,
-0.005444222,
-0.032996103,
-0.04533589,
-0.00957886,
-0.010166148,
0.025368117,
0.0029482504,
-0.013419855,
-0.02133136,
-0.0017365483,
-0.051033255,
-0.025840648,
0.015823008,
0.026893714,
0.007297215,
0.014783443,
-0.0052012065,
-0.006443286,
0.008836313,
0.01629554,
-0.011495983,
-0.019562747,
-0.00045565405,
-0.0015466923,
0.015336978,
0.03353614,
-0.025557129,
0.015958017,
0.025314113,
0.016552055,
-0.032213055,
0.030214926,
-0.019063216,
0.022019904,
-0.0014749691,
0.020210788,
-0.00041346386,
0.0059910067,
0.034265183,
-0.022330424,
-0.0032756464,
0.025948655,
-0.013109336,
-0.024436558,
0.0051337024,
0.017591622,
0.011988765,
0.005113451,
-0.00408401,
-0.011752499,
0.006946193,
0.0026984846,
0.0072567128,
0.021007339,
0.025840648,
0.011489232,
-0.00074423495,
-0.025543628,
-0.005268711,
-0.0068111843,
-0.0074592256,
-0.021722885,
0.0017652375,
-0.018725693,
-0.013750627,
0.0062508984,
-0.002219204,
-0.007182458,
-0.010631928,
-0.00054256583,
-0.019198224,
-0.021790389,
0.02115585,
-0.009801625,
-0.017443111,
-0.023721013,
-0.0007239837,
-0.031376,
-0.006379157,
-0.014999457,
0.017969646,
-0.00079317554,
0.02088583,
0.0012201403,
0.0046982993,
-0.0012007328,
-0.0030123796,
0.001913747,
-0.0076819896,
0.02211441,
0.2006768,
-0.021547373,
0.003888248,
0.015174967,
0.00408401,
-0.0022175163,
0.022613943,
0.0127515625,
0.007337718,
0.009990637,
0.009241339,
-0.0075199795,
-0.011016702,
-0.000012736164,
0.005515102,
0.00030904313,
-0.025314113,
-0.006463537,
-0.030997977,
-0.028108792,
0.016376544,
-0.017281102,
-0.02322148,
-0.0076887403,
0.008775559,
0.011833505,
-0.012893322,
-0.014162403,
0.02322148,
0.00611589,
-0.031322,
0.014702437,
0.008026262,
0.0012336412,
-0.015877012,
0.0016403546,
0.0051809554,
-0.011961763,
-0.009929883,
-0.013905887,
-0.01679507,
0.015539491,
-0.010240403,
-0.017132591,
-0.011489232,
0.0084312875,
-0.011853755,
0.020062279,
-0.0014395292,
-0.0014201218,
-0.042068683,
0.00043202753,
0.017699629,
0.02493609,
-0.0019626876,
-0.008262527,
0.016390044,
0.01301483,
0.018388173,
0.031024978,
-0.00026305584,
0.015931016,
-0.03826144,
0.015066961,
-0.0021078219,
0.032510072,
-0.015728503,
0.029377872,
0.039017487,
-0.023477998,
-0.011212464,
-0.012157525,
-0.010537422,
0.011732248,
-0.011306971,
-0.0058087455,
0.016862575,
0.029755898,
0.02162838,
0.013116086,
-0.009612612,
-0.0074254735,
-0.03734338,
-0.011036954,
-0.008485291,
-0.028513817,
0.0076144855,
-0.002008253,
-0.010307907,
-0.012900072,
-0.0052417093,
0.0018546807,
0.00478268,
-0.015404482,
0.005609608,
0.0047455523,
0.010152647,
0.018577185,
-0.0027676765,
-0.019900268,
-0.050412215,
0.062806,
-0.000993157,
-0.009761122,
-0.00541047,
0.02681271,
-0.009707119,
0.006338654,
-0.016957082,
0.000053080534,
0.023275483,
-0.015904013,
0.017011084,
-0.022046905,
-0.00059277215,
0.026421184,
0.024355553,
-0.01740261,
0.031646017,
-0.0069394424,
-0.0067166784,
-0.008667553,
-0.008438038,
0.035129238,
-0.017119091,
0.0043405266,
-0.012778564,
-0.014486424,
-0.025678637,
-0.028108792,
0.0036823598,
-0.009302093,
-0.003925375,
-0.0042392705,
0.00015473252,
-0.020926334,
0.011563487,
0.005440847,
-0.022708448,
0.013500861,
0.003496723,
0.015661,
-0.0172541,
0.01521547,
-0.015593494,
-0.026569694,
0.020008275,
0.004019881,
0.0045869173,
-0.0012749876,
-0.022964964,
-0.03434619,
0.011354224,
-0.0079520065,
0.028513817,
-0.01678157,
-0.020318795,
-0.036614336,
0.012258781,
0.012515298,
-0.03828844,
0.016039023,
0.004850184,
-0.0058897506,
-0.002752488,
-0.0002704391,
-0.17086689,
-0.014162403,
0.023599505,
-0.03529125,
0.02856782,
0.021223353,
0.0010606614,
0.011968513,
0.0025769768,
-0.0065512927,
0.029431876,
0.019198224,
-0.05130327,
-0.024085535,
0.021857893,
0.01709209,
-0.019076716,
0.045470897,
0.0050796987,
0.0024537814,
0.044633847,
-0.013514361,
0.00051851745,
-0.013986892,
-0.0035338502,
0.014324414,
0.0029296868,
-0.02118285,
0.004252771,
-0.01867169,
-0.026556194,
0.015390981,
0.013554865,
-0.015417983,
0.012596303,
0.012245281,
-0.0012766751,
0.0049008126,
0.000027871894,
0.011050454,
0.04104262,
0.031349,
-0.0045869173,
0.01975176,
-0.020575311,
0.03437319,
0.029620888,
0.014567428,
0.031781025,
-0.007715742,
0.012353288,
-0.009659866,
0.014972455,
0.02025129,
0.026097164,
0.0070542,
0.009896131,
-0.0044012805,
0.0044080312,
0.004026632,
-0.014661935,
-0.027285239,
0.038666464,
-0.018293666,
-0.010112145,
-0.03953052,
-0.000093767696,
-0.0030478192,
-0.036776345,
-0.004846809,
-0.018226162,
0.016538555,
0.00037570365,
-0.009788124,
0.024855085,
-0.008296279,
-0.008174771,
0.02289746,
-0.006855062,
-0.0018074277,
-0.020696819,
0.021074845,
-0.026596695,
-0.008242276,
-0.0075874836,
0.005160704,
0.024099037,
0.0011382913,
-0.014553928,
0.0058289967,
0.013460359,
-0.00462742,
0.0068753134,
-0.01694358,
0.0060517606,
0.009761122,
-0.00047084253,
-0.022370927,
0.014162403,
0.01051042,
0.03720837,
-0.019481743,
-0.011063956,
0.020899333,
0.027676765,
-0.0050121946,
-0.01427041,
0.007904754,
0.0439048,
-0.0057783686,
-0.0027423624,
-0.0076279864,
0.01944124,
0.024585068,
-0.005883,
0.016741067,
0.0019390611,
0.0022057032,
-0.0002223423,
-0.03375215,
0.078413,
0.0069596935,
-0.0068651875,
0.020912834,
0.009146833,
-0.025030596,
-0.13932888,
-0.025948655,
-0.0023407117,
0.0056872377,
-0.01976526,
0.014661935,
0.0013382728,
0.01849618,
-0.0028739958,
0.018590685,
-0.0018057402,
-0.028324805,
-0.0070474492,
-0.016403547,
0.018887704,
0.00816127,
0.025192605,
0.0037431137,
0.00988263,
0.046064936,
0.010402413,
-0.009977136,
0.0021230103,
-0.0038072427,
0.0030073167,
0.0054340963,
-0.040745597,
0.013460359,
0.010463167,
0.02588115,
0.009194086,
-0.023572503,
0.01161074,
0.0009197461,
-0.03699236,
-0.0036823598,
-0.027568758,
-0.019198224,
0.010301157,
0.004826558,
0.008390785,
0.0050931997,
-0.0010446291,
0.014081398,
-0.007513229,
-0.011948261,
-0.006514165,
0.021844393,
0.013433357,
-0.017119091,
-0.010746685,
0.0028706205,
-0.01427041,
-0.014850947,
0.020953337,
-0.011246217,
0.012427542,
0.010024389,
-0.030214926,
-0.0062036454,
-0.00050459465,
-0.0069394424,
-0.017348606,
-0.0034629707,
0.0077562444,
-0.01867169,
-0.012886572,
-0.018941708,
0.017578121,
-0.022195416,
-0.024234045,
0.0071757073,
-0.006571544,
0.0018445551,
-0.03215905,
-0.0038544957,
-0.026434686,
-0.02791978,
0.004158265,
-0.024274549,
-0.009383098,
-0.0069529433,
0.03548026,
-0.050277207,
0.026083663,
-0.00032022354,
0.014229908,
-0.0009568735,
-0.0018597436,
0.014067897,
-0.012684058,
0.026367182,
-0.016187532,
-0.020453803,
-0.010854692,
0.011860507,
-0.0058289967,
0.0043169004,
0.031322,
0.024207043,
-0.00399963,
-0.030106919,
-0.06350805,
0.0063757813,
0.011732248,
0.00799251,
0.008519043,
-0.015728503,
0.021250354,
-0.0045869173,
-0.006419659,
0.0032013915,
-0.030214926,
-0.003557477,
-0.010922196,
-0.014553928,
-0.010240403,
0.003672234,
0.027244737,
0.011914509,
0.029728895,
0.033941165,
-0.01819916,
-0.012177777,
0.0020909458,
0.0032655208,
0.00282168,
-0.014999457,
0.0029347497,
0.03156501,
-0.013818131,
-0.008714805,
0.0068753134,
-0.01975176,
-0.004846809,
0.0009087767,
-0.019279229,
-0.02854082,
0.008654051,
0.009956885,
0.018712193,
0.032510072,
-0.0146079315,
-0.04187967,
0.0045362893,
-0.008201773,
0.0059066266,
0.016498052,
-0.02619167,
0.008843063,
0.009862379,
0.0072702137,
0.01270431,
0.011030204,
0.009470854,
-0.014499924,
-0.023640007,
-0.0033144613,
0.0046375454,
-0.008633801,
-0.022856956,
-0.031349,
-0.00016886623,
0.026583195,
0.025287112,
-0.00052104885,
0.0034595956,
-0.021817392,
-0.0251116,
-0.014796943,
0.028918844,
-0.048846114,
-0.028000785,
0.0122722825,
0.014027394,
0.007344468,
-0.009707119,
-0.018698692,
-0.03434619,
-0.0109762,
-0.012758314,
0.017335106,
0.021911897,
-0.020953337,
-0.0073174667,
-0.000100992766,
0.025935153,
0.015066961,
-0.01914422,
0.012684058,
0.0068921894,
0.0066120466,
0.003965878,
0.010888444,
0.015715001,
0.017834637,
0.010604926,
0.042014677,
-0.0050594476,
0.0022158287,
0.013251095,
0.031159986,
-0.019171223,
0.003574353,
0.008539295,
-0.033401128,
-0.008897067,
0.03685735,
-0.011995515,
-0.038045425,
0.010004138,
-0.0049311896,
0.013338851,
0.009437102,
-0.017578121,
0.013932888,
0.002765989,
0.021277357,
0.0043169004,
-0.018226162,
-0.014783443,
0.02916186,
0.017564619,
0.010949198,
0.011590489,
0.0048231827,
0.009227838,
0.00072778075,
0.030160923,
-0.031673018,
0.016876075,
-0.028459815,
0.007384971,
0.007182458,
-0.022073908,
-0.007931756,
-0.0015365668,
-0.015093963,
0.013548113,
-0.022127911,
-0.013548113,
0.09374998,
0.04066459,
-0.012441043,
0.0038038676,
-0.018010149,
0.03464321,
0.029242864,
0.021439366,
-0.004111012,
-0.023964027,
0.01740261,
-0.024409557,
0.010139147,
-0.051357273,
-0.025273612,
0.014256909,
0.0018715569,
0.009761122,
-0.012265532,
-0.020372799,
0.014567428,
-0.0068955645,
0.02288396,
0.0060416353,
-0.023005467,
-0.009983887,
0.035345253,
-0.000034464112,
0.00019143798,
-0.04349977,
-0.017119091,
0.004097511,
-0.016511552,
-0.0054340963,
0.007702241,
-0.0024588443,
-0.0005121889,
-0.016039023,
0.026610196,
0.037370384,
0.021533873,
-0.011678245,
-0.015498988,
-0.030727958,
0.0066592996,
0.0013163339,
-0.0172541,
0.0030731335,
-0.021668881
] |
Protein-protein interactions (PPIs) represent an enormous source of opportunity for therapeutic intervention. We and others have recently pinpointed key rules that will help in identifying the next generation of innovative drugs to tackle this challenging class of targets within the next decade. We used these rules to design an oriented chemical library corresponding to a set of diverse "PPI-like" modulators with cores identified as privileged structures in therapeutics. In this work, we purchased the resulting 1664 structurally diverse compounds and evaluated them on a series of representative protein-protein interfaces with distinct "druggability" potential using homogeneous time-resolved fluorescence (H | [
-0.024424314,
0.0027912036,
0.0031129364,
-0.042085394,
0.0060513155,
0.027463663,
0.000025442885,
0.010124316,
-0.02238439,
-0.023904065,
0.018633123,
0.013547006,
0.013163665,
0.012527045,
-0.0029332452,
0.0065339147,
0.03367927,
-0.015908662,
-0.015799137,
-0.0056645516,
-0.022028431,
0.015799137,
-0.012835086,
-0.02216534,
-0.0098641915,
0.033323307,
0.023561796,
-0.03192685,
-0.015183052,
-0.029298225,
0.013115747,
0.0064141206,
-0.012376446,
0.007625753,
0.013143129,
-0.006520224,
0.008495116,
0.015169361,
-0.006872761,
0.0005685943,
0.018359307,
0.0058630677,
-0.0007465742,
-0.0055242213,
-0.005377046,
0.011582382,
0.012451746,
0.008015939,
-0.02219272,
0.01856467,
0.011000525,
0.022603443,
-0.0038984437,
-0.018920628,
0.026519,
-0.0165932,
0.005613211,
0.03121493,
-0.00874155,
-0.0091454275,
-0.018482525,
-0.010418667,
-0.027203538,
0.013909811,
-0.01235591,
-0.003140318,
-0.0045179506,
0.029845854,
0.008173383,
-0.011431783,
0.036554325,
0.02398621,
0.0065065334,
0.0038231446,
0.027764859,
-0.006886452,
-0.021111151,
-0.010049017,
-0.014252081,
0.0052367155,
0.012465436,
-0.012650262,
-0.0030427712,
0.0100011,
0.0036314738,
-0.014361606,
0.0059965523,
0.029079173,
0.013156819,
0.008953757,
0.014703875,
0.027751168,
0.0082281465,
-0.002039923,
-0.023958828,
0.015333651,
0.0029075749,
0.014963999,
-0.00335937,
-0.034336425,
0.00157786,
0.012568117,
-0.021330202,
-0.0072971745,
-0.02072781,
0.0009831677,
0.0016009632,
-0.022220101,
0.01712714,
0.016114023,
-0.012198467,
0.033104256,
0.014731257,
-0.01785275,
0.014840783,
-0.0047027757,
0.00883054,
-0.00013754934,
0.005818573,
-0.016469983,
0.03231019,
0.0131705105,
0.01045974,
-0.00991211,
0.026477927,
0.0020553253,
-0.00045393422,
0.010562421,
0.00500055,
0.011226422,
0.012438055,
0.024438005,
0.0038128765,
0.0041756816,
-0.021508183,
0.010096935,
-0.008022785,
-0.020399231,
-0.012794014,
-0.019769456,
0.014690185,
0.030886352,
-0.018126566,
-0.017195594,
-0.0020998202,
0.028449398,
0.037759114,
0.00093353866,
0.0016420354,
0.009364479,
0.00883054,
0.009939491,
-0.008543034,
0.01280086,
-0.0033901741,
0.022028431,
-0.0029606267,
0.017715842,
-0.012944613,
-0.012280611,
0.00811862,
-0.014854474,
0.0074956906,
0.010535039,
0.046055716,
0.021850452,
0.0061848005,
0.00874155,
0.010069554,
0.02379454,
-0.009576686,
0.03299473,
-0.037403155,
0.0035835563,
0.0010524772,
-0.0025413472,
0.011828816,
0.024739202,
-0.016114023,
-0.0036725462,
0.015415795,
-0.005910985,
0.020604592,
0.0060068206,
-0.01288985,
-0.003908712,
0.023712395,
-0.014306843,
-0.0061368826,
-0.036170986,
0.014142554,
0.022849876,
-0.011431783,
-0.015484248,
-0.6435752,
-0.032885205,
0.01549794,
-0.024068354,
0.014457442,
0.034911435,
0.002803183,
0.0114660105,
0.0012552715,
0.030913735,
0.007269793,
0.017565245,
0.019769456,
-0.024068354,
-0.013074675,
-0.025930298,
0.0008539611,
-0.046302147,
0.018550979,
0.011828816,
-0.0047814976,
0.01297884,
0.0010815699,
0.010076399,
0.012136858,
-0.005910985,
0.00930287,
-0.010480276,
-0.019208135,
0.0110758245,
-0.010274915,
0.006787194,
-0.019646239,
0.00946716,
0.054708272,
0.006318285,
0.015388413,
0.033432834,
0.046575963,
0.027847003,
-0.016018188,
-0.0020142528,
0.017387263,
0.0031916583,
-0.021740925,
0.011322258,
0.0049834363,
-0.0028511006,
-0.011315413,
0.0008073269,
0.00026033833,
0.0016249219,
-0.040743697,
-0.0045761364,
0.01692178,
-0.00026162184,
0.005969171,
-0.02436955,
0.006797462,
0.014197317,
0.013738677,
-0.013649687,
-0.00060795527,
-0.038991284,
-0.016127715,
-0.0044529196,
-0.010678792,
0.01714083,
-0.006992555,
0.0025054088,
0.00891953,
0.030064907,
-0.0013622305,
0.00045307857,
0.021590328,
0.01875634,
-0.0031711222,
0.02957204,
0.005055313,
0.027901767,
0.004565868,
0.0067495443,
-0.050902244,
0.013197891,
0.02220641,
0.014758638,
-0.014662803,
0.0076805158,
0.022042122,
-0.020084344,
0.014676494,
-0.019878982,
0.005784346,
-0.032939967,
-0.017606316,
0.0165932,
-0.01567592,
-0.00067041937,
0.026436856,
-0.027203538,
-0.024260025,
-0.028750595,
0.011089515,
-0.00063833164,
0.01840038,
0.004336548,
0.005041622,
0.008036476,
0.045124743,
-0.0024301098,
0.020399231,
-0.023205837,
-0.01605926,
-0.0043536616,
0.013505934,
-0.02883274,
0.017592626,
-0.00721503,
-0.010774627,
-0.03228281,
0.00928918,
0.0101585435,
0.011616609,
-0.0021768308,
-0.011281186,
0.010521349,
-0.0026577187,
-0.02020756,
0.009665676,
0.0013570965,
0.027189847,
-0.0106171835,
0.011192195,
-0.0006776926,
0.00013134572,
0.024205262,
0.020234942,
-0.006862493,
-0.0011551578,
-0.026231494,
-0.00964514,
-0.012273765,
0.009104355,
0.0011406114,
-0.006729008,
-0.022562372,
-0.03099588,
-0.00739301,
0.02127544,
-0.0073314016,
0.016894396,
0.0068488023,
-0.017168213,
0.0051374575,
0.016086642,
-0.0038642169,
-0.030147051,
-0.019427188,
-0.009898419,
-0.02434217,
-0.016990231,
-0.0018550978,
-0.034391187,
-0.0016711283,
-0.00045179506,
-0.032529242,
-0.001964624,
0.009651985,
-0.020809954,
-0.029489895,
0.015278887,
-0.027148776,
-0.029982762,
0.031981613,
-0.020481376,
0.03554121,
0.0004903003,
0.00015070531,
0.0000705395,
-0.0022949134,
-0.032364953,
-0.027162466,
-0.0091454275,
-0.014306843,
-0.0011705599,
0.0052606743,
0.03836151,
0.014649113,
-0.005869913,
0.021179605,
0.00093011593,
0.002197367,
0.001329715,
0.014265771,
-0.015470558,
-0.013238964,
0.007742124,
0.010240688,
-0.02291833,
0.022630826,
0.03157089,
-0.0153610315,
0.007269793,
-0.049560547,
-0.00043853212,
-0.016538437,
-0.0036314738,
-0.024657058,
0.00774897,
0.012739251,
-0.0036348966,
-0.0028836161,
-0.026984487,
-0.028695831,
-0.0058219954,
0.018345617,
-0.0023804808,
0.019632548,
-0.016867016,
-0.021001624,
0.004788343,
0.008193919,
0.017442027,
0.007543608,
-0.015593775,
-0.0034158444,
0.018687887,
0.014012492,
0.010090089,
-0.018619433,
-0.015922353,
-0.012951458,
0.024629675,
0.006068429,
0.0039634746,
0.001880768,
0.0025190997,
-0.020590901,
0.059034552,
0.0059212535,
0.002212769,
0.025122544,
-0.011404403,
0.0104528945,
0.010569266,
-0.0010695906,
0.02669698,
0.023507033,
-0.014566967,
0.029243462,
0.0004216326,
-0.0028904616,
-0.02650531,
-0.0028836161,
0.0059520574,
-0.009371324,
0.018989082,
0.023192147,
0.055447575,
0.01714083,
-0.008926375,
-0.006465461,
0.006225873,
-0.0079337945,
0.015881281,
-0.010665101,
-0.012041023,
-0.002342831,
-0.026614835,
-0.00248145,
-0.012479127,
-0.01641522,
0.009460314,
-0.017784296,
0.0058014593,
0.0138892755,
-0.00893322,
0.018550979,
0.007742124,
-0.0153610315,
-0.018906938,
-0.01226692,
0.019577786,
0.023151074,
-0.0015504785,
-0.014347916,
-0.029708948,
0.0014999938,
-0.02200105,
-0.009070128,
-0.011260649,
-0.0023051815,
0.014498514,
0.021740925,
-0.027340446,
-0.03367927,
0.034199517,
-0.023589177,
0.0036109376,
-0.0077968873,
0.0044426513,
-0.0112058865,
-0.010055862,
-0.0053804684,
0.041592527,
0.008467735,
-0.02165878,
-0.011397557,
-0.015032453,
0.0025584607,
0.002823719,
0.02580708,
-0.0010499101,
-0.011671372,
-0.002703925,
-0.0013143129,
0.0045692907,
0.019509332,
-0.0010516214,
0.0033747721,
0.010090089,
-0.04457711,
0.009966873,
0.02431479,
0.040962752,
0.012814551,
0.006643441,
0.0074683093,
0.003949784,
-0.009891573,
-0.024095736,
-0.014320534,
0.024574913,
-0.007769506,
0.017400954,
-0.0110758245,
0.009371324,
0.007016514,
0.0038334127,
0.013464862,
0.0004582126,
-0.033651885,
0.00097375526,
0.00065715646,
0.0041654133,
0.0031676993,
0.012876159,
0.010774627,
0.030639919,
-0.022562372,
0.03803293,
0.03660909,
0.01948195,
-0.01859205,
0.0044631874,
0.006694781,
-0.0074614636,
-0.0033781948,
-0.027518425,
-0.018099183,
0.01397142,
0.0019714693,
0.03693767,
-0.011000525,
0.009617758,
0.01226692,
0.0094055515,
0.01786644,
-0.008625179,
-0.0048157247,
-0.0050176634,
0.011815125,
-0.0151967425,
-0.014566967,
-0.019714693,
0.0022401505,
-0.0032703802,
-0.02795653,
0.004709621,
-0.009932646,
0.012102631,
-0.02361656,
-0.0144437505,
-0.027669024,
-0.02743628,
-0.027258301,
0.0066913585,
-0.023589177,
0.01343748,
-0.028613687,
-0.020289704,
-0.021193296,
-0.017359883,
-0.02471182,
0.019701002,
-0.028422017,
0.0029897196,
0.005746696,
0.004401579,
-0.0065133786,
-0.005661129,
-0.0072629475,
0.01767477,
0.020974243,
-0.017756915,
-0.009891573,
0.023397507,
-0.03411737,
-0.00062335737,
0.023657631,
-0.017907513,
-0.021562945,
0.004490569,
0.035787646,
-0.0060513155,
-0.015881281,
0.011856197,
0.0012655396,
-0.006828266,
0.015443176,
0.007892722,
0.021562945,
-0.019947436,
-0.020905789,
-0.0074203913,
-0.02216534,
0.001682252,
-0.040990133,
0.019427188,
0.00757099,
-0.0044323835,
-0.0056987787,
-0.018742649,
-0.004524796,
0.013738677,
-0.011301721,
0.0055379122,
0.02524576,
0.015306269,
0.02071412,
-0.016497364,
0.018674195,
0.00044494966,
-0.034829292,
-0.023274291,
0.0094397785,
0.022849876,
-0.0060068206,
-0.022534989,
0.0015085505,
-0.020700429,
-0.03428166,
-0.015867589,
-0.024752893,
-0.027080322,
0.055584483,
-0.0014221276,
-0.004073001,
-0.018277163,
0.012102631,
-0.02794284,
-0.008632024,
-0.017948585,
-0.016784871,
0.0025670175,
-0.006817998,
0.018797413,
-0.004514528,
-0.008440353,
-0.031598274,
-0.011342794,
0.014320534,
-0.019878982,
0.02363025,
0.017633697,
-0.008960602,
-0.013649687,
-0.009076973,
-0.025136234,
-0.04274255,
-0.02306893,
-0.026833888,
0.03529478,
0.04742479,
0.027682714,
0.01441637,
-0.009337097,
0.024109427,
0.006551028,
0.012657107,
0.007447773,
-0.01108267,
-0.03154351,
0.0077831964,
0.0023051815,
-0.012574962,
0.017524172,
-0.008748395,
0.005476304,
0.005712469,
-0.019057536,
-0.029298225,
-0.018797413,
-0.019249206,
-0.020645665,
-0.007879032,
-0.009179654,
0.0007735279,
-0.03699243,
0.0032207512,
-0.004336548,
-0.0051100757,
0.016497364,
0.0049149827,
0.022137957,
0.010247533,
0.03283044,
0.006995978,
0.026970796,
-0.0052264472,
-0.0064928425,
-0.012171085,
-0.005845954,
0.025546957,
-0.015347341,
0.023370126,
0.015005072,
-0.013458016,
-0.0025122543,
0.0016933758,
-0.019536713,
0.011767208,
-0.010500812,
-0.009268644,
-0.0008535333,
0.0014554989,
-0.023383817,
-0.034226898,
0.0007996259,
0.012424364,
-0.015169361,
0.020385541,
-0.017620007,
-0.008679941,
0.041400857,
-0.0121231675,
0.015306269,
-0.021316512,
0.010576111,
0.030448249,
0.021823071,
-0.0029161316,
-0.015566393,
-0.007372474,
0.0041962177,
0.029982762,
0.0035595973,
0.0046274764,
-0.027751168,
-0.022822496,
0.010350214,
-0.030256577,
-0.04381043,
0.010685638,
-0.0065339147,
0.010541884,
-0.010849927,
0.00066100695,
-0.018701578,
-0.00093268295,
-0.0052949013,
0.0006978009,
0.0022093463,
-0.025108851,
-0.022699278,
0.021713544,
-0.0047541163,
0.022055812,
-0.012431209,
-0.021316512,
0.019947436,
-0.02072781,
0.014580659,
-0.0047404254,
0.0034312466,
0.018290855,
0.0039908565,
0.027271992,
0.0028545232,
0.008625179,
0.017811678,
-0.009597222,
-0.01108267,
0.047506936,
-0.008570415,
-0.0025071204,
0.02201474,
-0.0031694106,
0.019783147,
-0.029270843,
-0.002614935,
-0.011801435,
-0.014347916,
-0.006674245,
0.023123693,
0.018523596,
-0.0018191596,
0.0059999754,
-0.00084412086,
0.009528768,
-0.0165932,
-0.0055960976,
0.024027282,
-0.013519624,
-0.012232693,
-0.01715452,
0.025752317,
0.010767782,
0.0064928425,
-0.012814551,
0.0028117397,
0.009590377,
-0.024615984,
0.0035356386,
0.003953207,
0.006054738,
-0.031078024,
-0.00014129291,
-0.019961126,
-0.020467686,
0.024191571,
-0.024232643,
-0.018728958,
0.008823695,
-0.0036109376,
0.008967447,
0.026916033,
-0.009590377,
0.029270843,
0.02235701,
0.0019115723,
-0.0014306844,
-0.008406126,
0.0034175557,
-0.03370665,
0.017291429,
0.0033816176,
-0.028805356,
-0.010795164,
-0.004168836,
-0.008426663,
0.011575537,
-0.018195018,
-0.0024147076,
-0.024040973,
0.009740975,
-0.011212732,
-0.0008381312,
0.009720439,
0.007968022,
-0.007858496,
0.011931497,
0.020905789,
-0.004500837,
-0.014649113,
0.008508807,
0.019002773,
-0.012342219,
-0.02525945,
-0.015894972,
0.011411248,
-0.029845854,
-0.017756915,
-0.008946911,
-0.009494541,
0.049533166,
0.01441637,
-0.04271517,
0.00006540546,
-0.00428863,
-0.044631876,
0.00027681002,
-0.009788893,
0.0009566418,
-0.0073519377,
0.009296025,
0.0013605192,
0.031598274,
-0.010514503,
-0.0029845855,
0.008604642,
-0.031653035,
0.018948011,
-0.008303446,
0.030913735,
0.0014452308,
-0.053092763,
-0.00014043725,
0.051340345,
-0.010966298,
-0.0006049604,
0.019947436,
-0.004620631,
0.023178454,
-0.009364479,
0.0048807557,
0.0016086642,
0.010562421,
0.023164764,
-0.022110576,
-0.00065458944,
0.023274291,
0.003806031,
-0.0082623735,
0.007981713,
-0.018989082,
0.008200765,
-0.011027906,
0.0033388338,
-0.030338721,
0.020453993,
-0.011979414,
0.0019218404,
-0.017962275,
0.011219577,
0.0069138333,
0.007201339,
0.0031197818,
-0.004500837,
0.0060615838,
0.0030958229,
-0.022534989,
0.023233218,
0.0029298225,
0.0009361057,
-0.0047849203,
0.0010088378,
-0.0056029432,
-0.0035253705,
-0.00080176507,
0.0005848521,
-0.0026577187,
0.013875584,
0.021727234,
-0.0025088317,
0.0037889176,
-0.013505934,
0.003939516,
-0.027833313,
-0.0059315213,
0.009528768,
-0.027723787,
0.0033251431,
-0.008782622,
-0.016757488,
0.00893322,
-0.0038162991,
0.003617783,
-0.02238439,
0.017948585,
0.20426613,
-0.009460314,
0.022699278,
0.007988558,
0.023014165,
0.0030787094,
0.009542459,
-0.016524747,
-0.009337097,
0.01820871,
0.03047563,
-0.0064791515,
-0.015662229,
-0.0093097165,
0.015580084,
-0.013232118,
-0.042140156,
-0.011671372,
-0.02398621,
0.014594349,
0.006325131,
0.009973718,
0.017003924,
-0.019974818,
0.016716417,
-0.005513953,
-0.0010824256,
0.0036520099,
0.0071671125,
0.009617758,
-0.010904689,
0.020823644,
0.0005091251,
-0.0043399706,
0.014115172,
-0.00077438354,
-0.015169361,
-0.023931447,
0.017770605,
-0.012835086,
-0.0005386458,
0.0389639,
0.008645714,
-0.030010143,
-0.007502536,
0.00046591365,
-0.018496215,
-0.0034945663,
0.025341595,
0.0043399706,
-0.0397032,
0.013923502,
0.030420866,
0.028558923,
0.012301147,
-0.006123192,
-0.007926949,
0.024273716,
-0.0039429385,
0.010918381,
-0.023862993,
0.0027655333,
-0.02506778,
0.017264048,
0.0056440155,
0.0151967425,
-0.02289095,
0.00680773,
0.013670223,
0.0057740775,
0.003771804,
-0.006280636,
-0.014306843,
0.0038779075,
-0.024506459,
-0.025697555,
0.02957204,
0.024930872,
0.028777976,
0.024109427,
-0.007071277,
-0.011842507,
-0.028586306,
-0.0063285534,
-0.016675344,
-0.02126175,
0.020577211,
-0.0027227497,
-0.02687496,
0.010610338,
0.0048602195,
-0.0034072876,
-0.011575537,
0.0022264598,
0.00857726,
-0.006301172,
-0.018674195,
0.0015735816,
-0.022439154,
-0.0015633135,
-0.036034077,
0.07935164,
-0.015799137,
0.02004327,
-0.0314066,
0.0029161316,
-0.00047447038,
0.00069009984,
-0.0007358783,
-0.011014216,
-0.011116897,
-0.019331353,
0.0124175185,
-0.016853325,
-0.0057090465,
0.035595972,
0.003860794,
-0.012396982,
0.014758638,
-0.0039771656,
0.005394159,
-0.029955382,
-0.011212732,
0.018318236,
-0.005270942,
0.013896121,
0.008139157,
-0.012006796,
0.0014349627,
-0.022439154,
0.004843106,
-0.011568692,
0.0019834486,
-0.009768357,
-0.010713019,
0.014402678,
0.0068351114,
0.0030547506,
-0.004038774,
0.0016069529,
-0.026382092,
-0.0009891574,
-0.018989082,
0.01549794,
0.03751268,
0.0005420685,
0.003871062,
0.0064072753,
0.025122544,
-0.009617758,
0.0014503648,
-0.021590328,
0.012602344,
-0.010959453,
0.0050826943,
-0.0036246285,
-0.011157969,
-0.012985685,
0.006010243,
0.005428386,
-0.017770605,
0.002525945,
0.027326755,
0.0052743647,
-0.023205837,
0.016141405,
-0.17458457,
0.019002773,
0.020453993,
-0.008604642,
0.037375774,
0.009179654,
0.0069241016,
-0.00680773,
0.017003924,
-0.011767208,
0.003126627,
-0.025820771,
-0.012896695,
-0.04329018,
0.012027332,
0.023657631,
-0.018455144,
0.013177356,
0.012321684,
0.0030530393,
0.026450546,
-0.011520774,
0.0025190997,
-0.016894396,
0.02143973,
0.022630826,
-0.004247558,
-0.013444326,
0.004713044,
0.02001589,
-0.0117945885,
-0.0037375772,
0.040907986,
-0.0043399706,
0.024438005,
-0.010261224,
0.007536763,
0.007879032,
0.0008633735,
0.035212632,
0.03874485,
0.026026133,
0.01271187,
-0.0061437283,
-0.025629101,
-0.003597247,
0.014635421,
-0.01856467,
0.017359883,
0.008981138,
0.011856197,
0.00277409,
0.00838559,
-0.00016931619,
0.013731832,
0.0057295826,
-0.009371324,
0.024793964,
-0.0069549056,
-0.012937767,
-0.008994829,
-0.0070918133,
0.040798463,
-0.00522987,
-0.006417543,
-0.026929723,
-0.0019269744,
-0.007413546,
-0.027176157,
0.010658256,
-0.009371324,
-0.011212732,
0.004487146,
-0.007981713,
0.009631449,
0.014635421,
-0.009521923,
0.015662229,
0.0056679742,
0.007926949,
0.011931497,
-0.004018238,
0.0063422443,
-0.014827092,
-0.005086117,
-0.013916656,
0.004836261,
0.010699328,
-0.021001624,
-0.0040011243,
0.018085493,
-0.02487611,
0.013930348,
-0.01514198,
-0.00042655272,
0.020125415,
0.009713594,
0.008399281,
-0.018304545,
-0.005185375,
0.015908662,
0.011657681,
0.003090689,
0.02145342,
0.012581808,
-0.001470901,
-0.002346254,
-0.010856772,
0.033323307,
0.008946911,
0.003686237,
-0.004610363,
-0.0022264598,
0.024999326,
-0.027532117,
0.043536615,
0.0064072753,
0.005616634,
-0.014950309,
-0.017264048,
0.059855998,
0.01143863,
0.009788893,
0.013013067,
-0.024109427,
-0.019167062,
-0.13592185,
-0.033076875,
0.015552702,
0.004600095,
-0.017578935,
0.01108267,
-0.003518525,
-0.007064432,
-0.023205837,
0.027819622,
0.014731257,
-0.018811103,
-0.003984011,
-0.021220677,
-0.01361546,
0.015484248,
0.0039566294,
-0.008378744,
-0.017058685,
0.0257797,
-0.0020382118,
0.014566967,
0.0060650064,
0.010692483,
0.00003708805,
0.008317136,
-0.0112058865,
0.017373573,
0.005219602,
0.005219602,
0.0050963853,
-0.009638295,
0.020248633,
0.004836261,
-0.012965149,
-0.0064723063,
0.012670797,
-0.017551553,
0.036746,
-0.02201474,
0.005175107,
-0.004678817,
0.0045384867,
0.006280636,
0.019413497,
-0.016127715,
-0.023110002,
-0.00014311122,
0.015949734,
0.005647438,
-0.020645665,
-0.020892099,
-0.049478404,
-0.00540785,
0.034747146,
-0.016606892,
-0.01982422,
0.0027518426,
-0.007543608,
-0.02216534,
-0.005442077,
-0.014484823,
-0.026792815,
0.02902441,
0.038854375,
0.000198516,
-0.01290354,
-0.02198736,
0.021946287,
-0.024396934,
-0.016196169,
-0.013191046,
-0.015265197,
0.01035706,
-0.022986785,
0.003552752,
-0.010576111,
-0.046767633,
0.018783722,
-0.022630826,
-0.018633123,
-0.03693767,
0.0026132236,
-0.010658256,
0.029270843,
0.009576686,
0.014238389,
0.013280036,
0.018153947,
-0.017948585,
-0.005507108,
0.029489895,
0.0052572517,
0.011616609,
0.0034962776,
0.0103228325,
-0.013102056,
-0.03499358,
0.006595523,
0.033487596,
-0.034692384,
-0.00054078497,
-0.052462988,
0.022110576,
0.023383817,
0.0091112,
0.016196169,
-0.007399855,
-0.0018585206,
0.0034244012,
0.013081521,
0.016333075,
-0.025368977,
-0.0023479653,
-0.002703925,
-0.000082198036,
-0.014388988,
-0.021713544,
0.04126395,
0.006410698,
0.01324581,
0.010466585,
-0.0030102558,
-0.014553277,
0.028422017,
-0.004425538,
0.0045316415,
-0.0049834363,
-0.03537692,
0.018742649,
-0.02959942,
0.012602344,
-0.002118645,
-0.030886352,
-0.024273716,
0.002128913,
-0.02165878,
-0.020946862,
-0.0076599796,
0.033569742,
0.017907513,
0.028038675,
-0.015867589,
-0.05197012,
-0.017565245,
0.0042201765,
0.003140318,
0.0015915508,
-0.03751268,
-0.00097375526,
0.00069651735,
-0.019714693,
0.025368977,
0.022302246,
-0.020974243,
-0.027778551,
-0.01714083,
0.015224124,
-0.011219577,
-0.008166538,
-0.012876159,
-0.024971945,
0.015046144,
-0.003100957,
-0.0058425316,
-0.0032344419,
0.013375872,
-0.010117471,
-0.011575537,
-0.016031878,
0.010733555,
-0.019906364,
-0.02272666,
0.024396934,
-0.0132595,
-0.002356522,
0.02343858,
-0.025327904,
-0.033131637,
0.013197891,
-0.0013784883,
0.014046719,
0.032364953,
-0.0043981564,
-0.0044084243,
0.01948195,
0.012335374,
-0.027463663,
-0.002967472,
0.037457917,
-0.022945711,
0.0076052165,
0.024027282,
0.0076325983,
-0.0060513155,
0.01749679,
-0.008967447,
0.0011012504,
-0.00014599912,
-0.013683914,
0.008043321,
-0.0012441478,
-0.0053462414,
-0.0071465764,
0.017770605,
-0.016867016,
-0.033076875,
-0.0072424114,
-0.028175583,
-0.038881756,
-0.020317087,
0.008057011,
0.021042697,
0.004216754,
-0.024917182,
-0.0011089515,
0.00257044,
0.004295476,
0.010665101,
0.0002988436,
-0.012924077,
0.034226898,
0.031707797,
0.009207035,
0.0032412873,
0.009809429,
0.01692178,
0.003586979,
0.009761511,
-0.027559498,
0.045891423,
-0.004836261,
-0.0034072876,
-0.019358734,
-0.02128913,
-0.006729008,
-0.01082939,
-0.007755815,
-0.0029503587,
0.010706173,
-0.0017575512,
0.066810906,
-0.0016026745,
-0.009076973,
0.0030787094,
-0.018482525,
0.015032453,
0.0017515615,
0.019961126,
-0.032200664,
-0.018701578,
0.00631144,
-0.013204738,
0.00595548,
-0.019221826,
-0.005472881,
0.010665101,
-0.025889225,
0.019030156,
-0.011671372,
-0.020495066,
0.009795738,
0.0015812827,
-0.0052743647,
-0.014594349,
-0.013122593,
-0.008467735,
0.006297749,
-0.002669698,
0.009419242,
-0.039593674,
-0.00428863,
0.012609189,
-0.01931766,
-0.023301672,
0.026217803,
-0.008823695,
-0.016812252,
-0.017017614,
0.012951458,
0.007721588,
0.002823719,
0.031105405,
-0.02004327,
-0.008960602,
-0.008002249,
0.011883579,
-0.016743798,
-0.018085493,
-0.015100908
] |
Endometrial cancer is associated with numeric and structural chromosomal abnormalities, microsatellite instability (MSI), and alterations that activate oncogenes and inactivate tumor suppressor genes. The aim of this study was to characterize a set of endometrial cancers using multiple molecular genetic and immunohistochemical techniques. Ninety-six cases were examined for genomic alterations by MSI, MLH1 promoter hypermethylation, p53 and mismatch repair protein expression (MLH1, MSH2, MSH6, PMS2), and PTEN, PIK3CA, KRAS, and BRAF mutation analysis. At least | [
-0.029383514,
-0.001962054,
0.006191153,
-0.027061015,
-0.044101365,
0.014222038,
-0.019493327,
-0.008487556,
-0.019154085,
0.01727521,
0.0068239686,
0.006510823,
-0.0044688513,
0.007835168,
-0.0013006967,
0.026030244,
0.029566182,
-0.01181473,
-0.0057246964,
-0.011266725,
-0.037760165,
0.012212686,
-0.007267592,
-0.015722528,
-0.0010120154,
0.029331323,
0.0034543895,
-0.050755713,
-0.0024317729,
0.0032863999,
0.0018837677,
0.0040708953,
-0.023146693,
-0.02027619,
-0.01980647,
0.009687948,
0.026317295,
-0.0036859869,
0.018097218,
-0.009903235,
-0.008591938,
0.00050845416,
0.0025051665,
0.007841692,
-0.016975112,
0.01109058,
0.011194962,
0.00522562,
-0.0060867714,
0.022781357,
-0.0034217702,
0.01889313,
-0.01306079,
0.012401878,
-0.029566182,
-0.0032472566,
0.029070368,
0.01767969,
-0.011605966,
-0.0076981676,
-0.014952712,
-0.007672072,
-0.043579455,
0.01761445,
-0.020850291,
0.0069348747,
0.0030515406,
0.014887473,
0.006501037,
0.0045699715,
0.041152578,
0.015918244,
-0.023172788,
-0.0034543895,
-0.0020093522,
-0.022507355,
-0.031184101,
-0.010027189,
0.011129724,
0.00869632,
0.03246278,
-0.0067913495,
0.0022980336,
-0.019271513,
0.01189954,
0.006713063,
0.00049540645,
-0.008004789,
0.046293385,
0.0067326347,
0.002614441,
0.017784072,
0.0036664153,
0.010405574,
-0.0044688513,
0.031523343,
-0.00042445934,
0.024125274,
0.027243683,
-0.023316314,
-0.004080681,
0.018162455,
-0.004123086,
-0.005783411,
-0.023955652,
-0.0072414964,
0.018880082,
-0.00031416514,
0.02125477,
0.003379365,
-0.015931292,
0.015487669,
-0.003734916,
-0.013882797,
0.0283136,
-0.009668376,
0.019741233,
-0.012277924,
-0.009700996,
-0.0066184667,
0.00012232257,
0.015161475,
0.018919226,
-0.018501697,
0.00616832,
-0.0027432877,
-0.018005883,
-0.002324129,
-0.012010446,
-0.0055094087,
0.0064357985,
-0.009864093,
0.020341428,
0.005499623,
-0.025208237,
0.008148314,
-0.013647937,
-0.028992081,
-0.015161475,
-0.03742092,
0.01149506,
0.03864741,
-0.012584547,
-0.0017239328,
-0.013791462,
-0.002974885,
-0.00895075,
0.0023339146,
0.01306079,
-0.0068370164,
-0.006921827,
-0.024177466,
-0.0020011973,
-0.010438194,
0.0076981676,
0.0076525,
0.014313372,
0.014678709,
-0.030714383,
-0.020432763,
0.0043579456,
0.0018413624,
0.0014752103,
0.027661212,
0.008004789,
0.030375142,
0.0061357003,
-0.00829184,
-0.015905196,
-0.017027302,
0.0061781057,
0.015918244,
-0.04230078,
-0.0024774398,
-0.017862357,
0.011847349,
-0.02548224,
0.031706013,
-0.023264123,
-0.03230621,
-0.025625763,
0.022729166,
0.0058225547,
-0.027400257,
-0.033689268,
0.006197677,
0.021228675,
-0.019167133,
-0.0116973,
-0.017301304,
0.0004140619,
0.011188438,
0.0009190503,
-0.0018234218,
-0.6417401,
-0.020589337,
0.00052394834,
-0.0081417905,
-0.0005235406,
0.03212354,
0.015122333,
-0.010614337,
-0.017666642,
0.014300325,
-0.048850745,
0.025364809,
0.0064357985,
0.0039991327,
0.0007645161,
-0.05991523,
-0.017666642,
-0.01871046,
0.019963045,
0.007261068,
-0.03431556,
-0.0037153445,
-0.0021381986,
0.017692737,
-0.015957387,
0.014456897,
0.01641406,
-0.020993816,
0.012780263,
0.02974885,
-0.036872916,
0.035829097,
-0.01456128,
0.0032945548,
0.041335244,
-0.005349574,
-0.00788736,
0.035307188,
0.016922921,
0.034680896,
-0.0014173109,
-0.014482993,
0.0037447019,
0.0005647226,
-0.015265858,
0.028678935,
0.0123496875,
-0.002516583,
0.018123312,
-0.004273135,
-0.0009769496,
0.0059301984,
-0.0099684745,
-0.02132001,
0.034680896,
0.008096123,
0.028261408,
-0.019963045,
0.0009475922,
0.0028395148,
0.014600422,
0.025847577,
-0.023903463,
-0.023825176,
-0.0018609341,
0.022037635,
-0.0103664305,
0.0025443095,
-0.0012786787,
0.003382627,
0.029070368,
0.042483445,
-0.009642281,
-0.0119517315,
0.031340674,
0.06111562,
0.0042600874,
0.017757976,
-0.014522136,
0.01461347,
0.0134652695,
-0.016531488,
-0.035385475,
-0.0040545855,
0.014222038,
-0.0294618,
-0.012049589,
0.013830606,
-0.009648805,
0.0067783017,
0.0036044386,
-0.012649786,
0.0042666113,
-0.045667093,
0.0023437005,
0.0121148275,
-0.0038164645,
0.019976093,
-0.00027644902,
-0.032958593,
-0.02860065,
-0.0108426735,
-0.0030352308,
-0.00035575483,
0.009714044,
-0.01456128,
-0.03050562,
0.0003559587,
0.024947282,
-0.014822234,
0.0057149106,
0.016466249,
0.013341316,
-0.018279886,
-0.0019848878,
-0.016831586,
0.010542575,
0.02351203,
-0.035724714,
0.00037247225,
0.016557584,
0.0057214345,
-0.005202787,
-0.029044272,
0.005904103,
0.008135267,
0.0004603406,
-0.0070457803,
0.012669357,
-0.005049476,
0.007274116,
-0.016009578,
0.02044581,
-0.013132552,
-0.0018038503,
-0.03217573,
0.023420695,
0.00017706193,
-0.014430802,
-0.00776993,
-0.0048733316,
-0.0073458785,
0.014404707,
0.012330116,
-0.0029683611,
-0.0049222605,
-0.01698816,
-0.0009671638,
0.0018462554,
0.0023632722,
-0.0028525623,
0.008989894,
-0.0025638812,
0.014522136,
0.008826797,
0.00013710323,
0.000605089,
-0.0145743275,
-0.0135435555,
-0.010046761,
0.0024627612,
0.0091725625,
-0.0041557057,
-0.007946075,
0.008709367,
0.0027954786,
-0.014378611,
0.016401011,
-0.015122333,
-0.025312617,
-0.008311411,
-0.0034967947,
-0.020106569,
0.009309564,
0.004279659,
0.011651633,
-0.021280866,
-0.0071893055,
-0.013008598,
-0.01680549,
0.017366543,
-0.012362735,
-0.020432763,
-0.016127009,
0.04193544,
0.037238255,
0.023772985,
-0.008878988,
0.0058943173,
0.025782337,
-0.021072103,
0.020054378,
-0.0008130374,
0.018149408,
0.025978053,
-0.008715891,
0.0068826834,
0.00016411612,
-0.0037740592,
0.030140283,
0.01525281,
-0.028339695,
0.0006059045,
0.0012020231,
0.01444385,
-0.021933254,
0.00412961,
-0.015970435,
0.0016546167,
-0.0041915867,
0.0012582915,
0.01432642,
-0.015579003,
0.0082200775,
-0.0107643865,
-0.011436345,
-0.0066347765,
0.0010071226,
-0.016688062,
-0.0017565521,
-0.0100532845,
0.018071122,
0.01779712,
-0.004537352,
0.011912588,
0.018110266,
0.014013275,
0.0070066373,
0.020876387,
-0.01007938,
-0.014026322,
0.025743194,
0.0068370164,
0.010001094,
0.03379365,
0.000959009,
0.021228675,
-0.01375232,
0.031679917,
0.00051701674,
-0.02386432,
0.01761445,
0.012845501,
-0.0064814654,
0.021972397,
-0.035385475,
0.023264123,
0.020471906,
0.012760691,
0.00906818,
-0.012610642,
-0.0009802115,
-0.002625858,
0.01461347,
-0.0031608155,
-0.019023607,
-0.011410249,
0.0222464,
0.05464394,
0.005770364,
0.026539106,
-0.020667622,
-0.0021952824,
0.003332067,
-0.009296516,
0.012525831,
0.043109737,
0.010947055,
0.008467984,
0.001484996,
-0.0123496875,
0.001867458,
0.0071762577,
-0.0259911,
-0.0046254243,
-0.0011041651,
0.0038947507,
0.0340807,
0.025978053,
0.011260201,
-0.0133869825,
-0.036429293,
0.026565202,
0.034393847,
-0.008507127,
0.0017483974,
-0.0069870655,
-0.010007618,
-0.0051114527,
-0.012180067,
0.03559424,
0.026604345,
0.004289445,
0.0032668281,
-0.021463534,
-0.008794177,
0.01221921,
-0.020941624,
0.013504412,
0.033193454,
0.017066445,
-0.015722528,
-0.032227922,
0.015083189,
0.018958367,
0.016401011,
-0.0048733316,
-0.011221058,
-0.010157667,
-0.013439174,
-0.014404707,
-0.030636096,
-0.01951942,
-0.0039730375,
-0.0020142451,
0.0072414964,
0.013191267,
-0.003738178,
0.024229655,
0.0068892073,
-0.01813636,
-0.04378822,
-0.01860608,
0.0027693831,
0.008278792,
0.024073083,
-0.027635116,
0.012186591,
0.01751007,
0.009896711,
-0.0017826477,
-0.020576289,
0.0058388645,
-0.017523117,
-0.017953692,
-0.00004248161,
-0.0022442115,
-0.0033059714,
0.015853006,
0.022311637,
0.0008978477,
-0.017483974,
-0.015735576,
0.018345125,
-0.0076003093,
-0.009531375,
0.05044257,
0.044414513,
0.014065465,
-0.021685347,
0.005356098,
0.016531488,
0.0027481804,
-0.020772005,
-0.021046007,
0.022207256,
0.0076068332,
0.04444061,
0.000061670966,
-0.014978807,
0.01751007,
-0.015970435,
0.0026307509,
-0.0044068745,
-0.0097270915,
0.01744483,
0.006321631,
0.011547251,
0.0027400258,
-0.008017837,
0.0077307867,
-0.009805378,
0.0021398296,
-0.0090942755,
0.010907912,
-0.011906064,
-0.0079852175,
-0.02044581,
0.015409383,
0.025417,
-0.01242145,
-0.010653481,
-0.014874425,
-0.01085572,
0.0020289237,
-0.01727521,
0.0036468436,
0.0069413986,
-0.009133419,
-0.0036794632,
-0.020145712,
-0.0152136665,
-0.025912814,
-0.0070001134,
0.002772645,
-0.032019157,
-0.024934234,
-0.007424165,
0.011364583,
0.02195935,
0.0033956748,
-0.0071827816,
0.0015437109,
0.0392737,
-0.0038556075,
-0.0028101574,
-0.010157667,
-0.028678935,
-0.0058714836,
-0.013256505,
0.016140057,
0.00006977483,
-0.037107777,
0.017562259,
-0.011619014,
-0.02310755,
-0.011358059,
-0.009851045,
-0.010901388,
0.028157026,
0.0014523767,
0.020928577,
-0.017705785,
-0.0021055792,
0.0011840825,
-0.039299797,
-0.0340807,
-0.03102753,
-0.013047742,
-0.017862357,
0.006869636,
0.0153702395,
-0.024281846,
0.0015722528,
0.0065825856,
-0.023903463,
0.00696097,
0.009916283,
0.0058323406,
0.02051105,
0.003734916,
0.028861605,
0.009616185,
-0.00095248513,
0.023825176,
-0.006667396,
0.021567916,
-0.0007082477,
-0.00728064,
0.016074818,
-0.0019538992,
-0.007933027,
-0.02015876,
-0.010444717,
-0.0022083302,
0.055635568,
-0.001210178,
-0.021098198,
-0.006341202,
-0.013132552,
-0.011879968,
0.011136247,
0.009916283,
-0.007835168,
-0.021385249,
0.020028284,
-0.005088619,
-0.021280866,
0.0008322013,
-0.031445056,
-0.010105476,
0.033115167,
-0.007476356,
-0.0053593596,
0.011142771,
0.023068408,
-0.025521383,
-0.012251829,
-0.0015608361,
-0.016792443,
-0.013086884,
-0.007906931,
0.03799502,
0.020341428,
0.053756695,
-0.0037120825,
0.033141263,
0.010014142,
0.012095257,
0.0049581416,
-0.032201827,
0.023668602,
-0.009903235,
0.01230402,
0.02212897,
-0.016035674,
0.015083189,
-0.020693718,
0.027269779,
0.01380451,
-0.024177466,
-0.011919112,
-0.0020321857,
-0.05459175,
-0.043970887,
0.016205294,
-0.004791783,
0.027400257,
-0.053965457,
-0.008167886,
0.026878348,
0.007991741,
-0.009087752,
0.0058747455,
0.016896825,
-0.018827891,
0.018110266,
-0.020915529,
-0.0002982632,
-0.01181473,
-0.017836262,
-0.00037593805,
-0.013765367,
0.026591297,
0.0029031225,
0.049946755,
0.007841692,
-0.013608795,
-0.009857569,
0.01739264,
-0.01048386,
-0.015696432,
-0.000007899999,
-0.037186064,
-0.015226714,
-0.013191267,
0.0055061467,
-0.023251075,
-0.0066934912,
0.0094922315,
-0.01589215,
0.025364809,
-0.0060737235,
-0.010986199,
0.022115922,
0.006194415,
0.014430802,
-0.030192474,
0.02090248,
0.005144072,
-0.0070784,
-0.015265858,
0.0035555095,
-0.012806358,
0.0068043973,
0.030766575,
0.019284561,
0.009407422,
0.0033027094,
0.0012721547,
-0.0023485934,
0.0017223018,
-0.033871938,
0.009831473,
0.0081417905,
-0.0036240101,
-0.0111623425,
-0.009714044,
-0.029670564,
0.020745909,
-0.015918244,
0.0145743275,
-0.003731654,
-0.013119504,
-0.0035196282,
0.021868015,
-0.015187571,
0.019963045,
0.0111623425,
-0.0025752978,
-0.008076552,
-0.02051105,
-0.009250849,
-0.010190286,
0.01189954,
0.03298469,
-0.008839845,
-0.0070392564,
0.0069740177,
-0.007508975,
-0.024112226,
-0.01606177,
-0.0064390604,
0.039821707,
-0.007880836,
0.008454937,
0.009583566,
0.0030156593,
0.02351203,
0.015200619,
0.0038490838,
-0.013882797,
-0.026904443,
-0.007809073,
0.017810168,
0.009557471,
-0.0048244023,
-0.014913568,
-0.03340222,
0.018919226,
-0.010262049,
-0.02524738,
0.026291199,
-0.046293385,
-0.033428315,
-0.021124294,
0.0060769855,
0.03616834,
0.034941852,
0.007991741,
-0.011345011,
0.045510523,
-0.0028623482,
-0.0010250632,
0.012812882,
-0.0010185393,
-0.006406441,
0.015605099,
-0.013276077,
-0.021398297,
-0.0077503584,
-0.012003922,
-0.030192474,
-0.028757222,
-0.002116996,
0.006191153,
0.01238883,
-0.025077758,
0.0008619664,
0.0036664153,
0.0062433444,
-0.012571499,
-0.021176483,
0.022102874,
-0.028261408,
0.008083076,
0.0147309,
0.0077568823,
-0.014548232,
-0.020524098,
-0.011860397,
-0.006005223,
-0.01779712,
0.0057736253,
-0.004791783,
-0.0024448205,
0.00039510193,
0.0071958294,
-0.017575307,
-0.005388717,
-0.03061,
0.015957387,
-0.0029047534,
-0.016622823,
-0.012069161,
0.018045027,
0.005228882,
0.023720793,
-0.025417,
-0.004344898,
-0.024568897,
-0.017536165,
-0.03569862,
0.00041875095,
-0.01831903,
0.01923237,
0.01331522,
0.010509956,
-0.03021857,
-0.017118637,
-0.03379365,
-0.03736873,
0.003079267,
0.000102190315,
0.015448526,
0.04096991,
-0.014039369,
0.0005736929,
0.003376103,
-0.007515499,
-0.011886492,
0.012232258,
0.0107643865,
-0.007300211,
0.029096464,
0.0049516177,
-0.0065727998,
-0.0121148275,
0.042092014,
0.0074437363,
-0.01871046,
0.0080635045,
-0.012134399,
0.0077373106,
-0.011416773,
-0.009668376,
0.0073524024,
0.004442756,
0.022494307,
-0.0009834735,
-0.0040023946,
0.0056268387,
0.01651844,
0.0004099845,
0.017862357,
-0.0034185082,
0.01282593,
0.0137001285,
-0.0054865754,
-0.012767215,
0.0144177545,
-0.01906275,
0.0116385855,
0.018919226,
0.00058796385,
0.026043292,
0.002330653,
0.0052810735,
-0.02408613,
-0.025912814,
-0.004302493,
-0.008500604,
0.008246172,
-0.014874425,
-0.031836487,
-0.008128743,
-0.0011465703,
0.011827777,
-0.011188438,
-0.0005043768,
-0.028731126,
-0.025899766,
0.00975971,
-0.0037120825,
0.001968578,
-0.014509088,
0.0045210426,
-0.013647937,
-0.0027530733,
-0.021580964,
-0.017575307,
-0.010757863,
0.007991741,
-0.0015518657,
0.009002942,
0.013856702,
-0.0057083867,
-0.012897693,
-0.025847577,
0.00728064,
0.18527792,
0.002368165,
-0.009883665,
0.02998371,
0.002329022,
-0.009198657,
0.016022626,
0.0075937854,
-0.009022513,
0.00918561,
0.011403726,
0.013008598,
0.0013088515,
-0.0015445264,
0.05845388,
-0.014756995,
-0.03282812,
-0.013197791,
-0.013634889,
-0.0046254243,
0.0055191945,
-0.008252696,
0.020758957,
-0.011658157,
0.012454069,
-0.0023844747,
-0.028783318,
0.008076552,
0.026252056,
-0.0117951585,
-0.027087111,
0.022389924,
0.019897806,
-0.009518327,
0.0053626215,
0.0074894037,
0.0021430915,
-0.0032668281,
-0.011801682,
-0.0024399275,
-0.0026943586,
-0.0011734812,
-0.0022523664,
0.0036207482,
0.007052304,
0.0072480203,
-0.005796459,
-0.007822121,
0.015500717,
-0.03535938,
-0.03165382,
0.010105476,
0.009231277,
0.011279772,
-0.018162455,
-0.003382627,
0.02115039,
-0.012356211,
-0.030427333,
0.014430802,
0.0005749161,
-0.010144619,
-0.018619128,
0.015096237,
-0.015461573,
0.027269779,
-0.040682856,
-0.0066510863,
0.006713063,
-0.013413078,
0.0030564335,
0.0021985443,
-0.006213987,
0.010418622,
-0.016675014,
-0.025456144,
0.040865526,
0.015735576,
0.0059367223,
0.012506261,
0.0062955352,
-0.011031865,
-0.018045027,
0.0066282526,
-0.022820499,
-0.03327174,
0.028000453,
0.0064357985,
-0.0058258167,
-0.0077373106,
-0.010633909,
-0.004240516,
0.0045862813,
0.001540449,
0.0070262086,
-0.00079509674,
0.015983483,
0.009916283,
-0.0173274,
-0.014482993,
-0.04812007,
0.08016533,
-0.001388769,
0.0004050916,
-0.0058910553,
0.0117168715,
-0.0033206502,
0.012251829,
-0.0006266993,
-0.016322725,
0.018762652,
-0.03230621,
0.008115695,
-0.003382627,
-0.02206373,
0.017888453,
0.016257485,
-0.031314578,
0.010940531,
-0.01525281,
-0.012669357,
-0.014665661,
0.024855947,
0.009250849,
-0.0143394675,
-0.0010609445,
-0.026486915,
0.0044655893,
0.009250849,
-0.034211177,
-0.0008635974,
-0.016205294,
0.0027481804,
0.006360774,
0.004491685,
-0.02293793,
0.019976093,
-0.014130704,
-0.011286296,
0.012441021,
0.003372841,
-0.00078367995,
-0.00047420384,
0.018593032,
-0.014091561,
-0.031679917,
0.0035652954,
0.008846369,
-0.023603365,
-0.011064485,
-0.018279886,
-0.023277171,
0.0016717418,
0.01963685,
0.035046235,
-0.019101894,
-0.025390904,
-0.04579757,
-0.0034446036,
0.023133645,
-0.011847349,
0.008278792,
0.022220304,
-0.0038132025,
-0.0018511483,
0.0054930993,
-0.16314895,
0.010881816,
0.01577472,
-0.037864547,
0.010503432,
0.020002188,
-0.0036892488,
-0.024882043,
0.0023453315,
-0.008839845,
0.036664154,
-0.0011539096,
-0.044858135,
-0.016648918,
0.01623139,
0.029148655,
0.0008725677,
0.015905196,
0.0369773,
0.0025573573,
-0.0022751999,
-0.019114941,
0.0023795818,
-0.0046156384,
0.0036468436,
0.011651633,
0.006497775,
0.010138095,
-0.00947266,
0.00038572386,
0.00222464,
-0.012121351,
0.019480279,
0.0054702656,
0.016727205,
-0.011827777,
-0.013778415,
-0.021881063,
-0.0067717778,
-0.006005223,
0.017549213,
0.001442591,
0.014913568,
-0.0038621314,
0.017340448,
0.030192474,
0.0018266838,
-0.015761672,
0.026643489,
0.009276944,
0.029279131,
-0.007835168,
0.026982728,
0.005594219,
0.014652614,
0.006497775,
0.000668289,
-0.011149295,
0.017692737,
-0.006403179,
0.0012224102,
-0.022194209,
0.042718306,
0.008676748,
-0.008852893,
-0.02703492,
-0.020145712,
0.034733087,
-0.029827137,
0.0044590654,
-0.006308583,
-0.0071893055,
0.020406667,
-0.013830606,
0.034054603,
0.003917584,
-0.0052712876,
0.023812128,
-0.014991855,
-0.008676748,
-0.013843654,
-0.0007808258,
-0.023994796,
-0.017053397,
0.011351535,
-0.006902255,
0.022285542,
0.0006739974,
-0.00066217285,
-0.0035750812,
0.02368165,
-0.02039362,
0.010673053,
-0.02674787,
0.03961294,
0.0011449393,
-0.00776993,
0.0051212385,
-0.002519845,
-0.015187571,
0.02090248,
-0.022755262,
-0.018932274,
0.02813093,
0.032723736,
-0.001663587,
0.011064485,
-0.0071827816,
0.03883008,
0.0026307509,
-0.025443096,
-0.009648805,
-0.008272268,
0.016440155,
0.011860397,
0.03773407,
0.008246172,
0.016818538,
0.009133419,
-0.021111246,
0.07238887,
-0.0048048305,
0.033480503,
0.020041332,
0.02415137,
-0.019793423,
-0.12776348,
-0.010294668,
0.010183762,
0.014000227,
-0.015004902,
0.0028509316,
-0.011886492,
0.026773965,
-0.019049702,
0.050755713,
-0.015866054,
-0.026708726,
-0.018071122,
-0.0023143431,
0.0019017083,
-0.001958792,
-0.007724263,
0.00063852384,
-0.0038458218,
0.040160947,
-0.0042274683,
0.007717739,
0.004289445,
-0.01525281,
0.008970322,
0.012284448,
-0.027348066,
0.010092428,
0.009518327,
0.016270533,
-0.0011636955,
-0.0086637,
0.00071558706,
0.0030335998,
-0.018867034,
-0.014287277,
-0.013713176,
-0.02813093,
0.03274983,
-0.008931179,
-0.004325326,
0.016779395,
0.021515725,
0.020315334,
-0.0051701674,
-0.013856702,
-0.034967948,
0.0077895015,
0.014991855,
-0.02663044,
-0.0207981,
0.008474508,
-0.029566182,
0.0028395148,
-0.0067391586,
-0.005085357,
0.017888453,
0.004322064,
-0.0075415946,
0.0078025493,
-0.01380451,
-0.01083615,
-0.009694472,
0.024829851,
0.018919226,
-0.006412965,
-0.018045027,
-0.015500717,
0.013987179,
-0.014978807,
-0.002315974,
0.0059791277,
-0.023303267,
-0.021646203,
-0.020015236,
0.005346312,
0.00054515095,
-0.0051114527,
0.010007618,
-0.012010446,
0.001767969,
-0.012069161,
0.01912799,
-0.01796674,
0.02553443,
0.008239648,
-0.00633794,
-0.013895844,
0.00197184,
0.0064879893,
-0.010301191,
0.042848784,
0.018958367,
-0.02258564,
-0.007463308,
0.014169848,
-0.004090467,
-0.020524098,
0.028183121,
0.016909873,
-0.020471906,
-0.0093291355,
-0.05610529,
0.019910853,
0.007300211,
-0.0028166813,
0.009420469,
-0.0020501264,
0.01230402,
0.0031118863,
0.009374802,
0.042848784,
-0.0032423637,
0.01501795,
0.0010030451,
-0.013530508,
-0.027139302,
-0.006611943,
0.029540086,
0.005186477,
0.00886594,
0.039873898,
-0.004504733,
-0.006765254,
0.00071925676,
0.021267818,
-0.008024361,
-0.016622823,
-0.01727521,
0.017196923,
-0.03773407,
0.0056986012,
0.03794283,
-0.007900408,
-0.032045253,
-0.011729919,
-0.0053169546,
-0.03160163,
-0.0034641754,
0.021163436,
0.015748624,
0.03021857,
-0.02218116,
-0.0057116486,
-0.0051147146,
0.020785052,
-0.0014075252,
0.013152123,
-0.0193498,
-0.007867788,
-0.007841692,
-0.004834188,
0.024138322,
-0.008878988,
0.013276077,
-0.027713403,
0.0017059922,
-0.006660872,
-0.0012737857,
0.004739592,
-0.019623803,
-0.01958466,
0.020341428,
0.02315974,
-0.0025508334,
0.0073784976,
-0.009831473,
-0.0064847274,
-0.026447771,
-0.00935523,
-0.0004260903,
-0.03627272,
-0.018736556,
-0.0035098423,
0.0012542141,
0.019623803,
-0.017353496,
0.00049255224,
-0.008467984,
-0.0031037314,
0.009505279,
0.022794405,
0.0038164645,
0.0076916437,
0.0051114527,
0.0106861,
0.030923147,
-0.00029010838,
-0.010829626,
0.010046761,
0.00374144,
0.0059138886,
0.005450694,
0.019963045,
0.032097444,
-0.009772758,
-0.016427107,
0.018071122,
-0.0077046915,
0.012669357,
0.030975338,
0.016661966,
0.0100532845,
-0.011886492,
0.011142771,
-0.018697413,
-0.010203334,
0.013093408,
-0.032227922,
-0.019741233,
0.0027400258,
0.013687081,
0.024112226,
0.013530508,
0.009100799,
-0.0011734812,
-0.008337507,
-0.003986085,
-0.0021773418,
0.007880836,
-0.018880082,
0.027739499,
0.010118524,
-0.0008269006,
0.013674033,
0.0061813677,
0.026708726,
0.012891169,
0.020941624,
-0.027139302,
0.028574554,
-0.00645537,
0.022259448,
0.0033630554,
-0.033141263,
-0.01906275,
-0.0054637417,
-0.013713176,
-0.0069348747,
-0.0011588025,
0.003434818,
0.09519632,
0.012480165,
-0.017118637,
0.00788736,
-0.038047213,
0.017536165,
0.032201827,
-0.010438194,
-0.024360133,
-0.01987171,
0.0017859096,
-0.02270307,
0.010170714,
-0.033532694,
-0.018123312,
0.031340674,
-0.009250849,
0.02015876,
-0.0072871638,
-0.031158006,
0.0030172903,
-0.012206162,
0.0026013935,
0.028992081,
-0.011553775,
0.028861605,
0.039091032,
0.011136247,
0.0025410475,
-0.01553986,
0.013413078,
-0.019532468,
-0.034028508,
-0.00869632,
0.017536165,
-0.020537145,
0.009159515,
-0.024581945,
0.024660232,
0.019558564,
-0.013687081,
-0.0007608464,
-0.014665661,
-0.014652614,
-0.00927042,
-0.012062637,
-0.022559544,
-0.018031979,
-0.0039077983
] |
Plant resistance against the necrotrophic pathogen Plectosphaerella cucumerina is mediated by a combination of several hormonal-controlled signalling pathways. The priming agent β-aminobutyric acid (BABA) is able to induce effective resistance against this pathogen by stimulating callose-rich cell wall depositions. In the present research it is demonstrated that BABA-Induced Resistance (BABA-IR) against P. cucumerina in Arabidopsis has additional components such as the induction of defences mediated by indolic derivatives. Chromatographic approach for the detection and characterization of metabolites enhanced by BABA compared | [
-0.027753362,
-0.023757316,
0.0017337298,
-0.015683113,
-0.019049644,
0.020103397,
-0.011009655,
-0.00553904,
-0.02357941,
-0.021608757,
-0.0006427716,
0.0029799284,
-0.00044861436,
0.020869762,
0.007253098,
0.014957803,
0.043162774,
0.018132744,
-0.0019313083,
0.028464988,
0.0015840492,
0.015039914,
0.0014369345,
-0.0028978179,
-0.0030363793,
0.009559035,
0.020226562,
-0.043272253,
-0.01018855,
0.0056690485,
-0.0047521475,
-0.008984261,
0.0050874325,
0.0102501325,
-0.013055576,
-0.03355584,
0.009743785,
-0.019993916,
0.021294,
0.030627232,
-0.00044177182,
-0.003215996,
-0.0019432828,
-0.014369344,
-0.021622442,
-0.0026395118,
-0.0112149315,
-0.007909982,
-0.021512961,
0.03040827,
0.017708506,
0.008026306,
-0.02664487,
0.0047316197,
-0.01594313,
0.004772675,
0.0030928303,
0.029313464,
0.009182695,
-0.0051763854,
-0.007862085,
0.0012692921,
-0.024017332,
0.0027250436,
-0.000075054166,
-0.0016045768,
0.0175306,
-0.0008095586,
-0.00032908365,
0.0045366073,
0.02430472,
0.04559872,
0.01443777,
-0.020664485,
0.019774955,
-0.00992169,
-0.04710408,
0.012857142,
-0.0018936744,
0.010277502,
0.024400515,
-0.0077389185,
-0.008902151,
0.034103245,
0.034486428,
-0.01833802,
-0.0089568915,
0.024838438,
0.0056279935,
-0.02742492,
0.006517524,
0.022594083,
0.029614534,
0.013541397,
-0.021649813,
0.02424998,
0.0016755682,
0.032981068,
-0.005939329,
-0.025974302,
0.007971565,
-0.010448567,
-0.028081805,
-0.015546262,
-0.0007082034,
0.002497529,
-0.010599102,
0.0041226335,
0.020678172,
-0.032351553,
-0.02115715,
0.034541167,
-0.033336878,
-0.060542837,
0.0035889149,
-0.0075746975,
0.02352467,
-0.016162092,
-0.027247014,
-0.016504219,
0.0077594463,
0.005901695,
0.034130614,
-0.014725157,
0.008525811,
0.0016815554,
0.00047983346,
-0.015710484,
-0.02293621,
-0.0046118754,
0.0013471261,
0.04877366,
0.0017670873,
0.0002642933,
-0.008881624,
0.019610735,
-0.048937883,
-0.043655436,
-0.02489318,
-0.02564586,
0.006757013,
0.022553029,
-0.021950884,
-0.002713069,
-0.006004333,
0.014123013,
0.016435793,
0.0272607,
-0.009080057,
0.024427885,
0.0008997947,
-0.016271573,
-0.009299018,
-0.0029611113,
0.008518969,
-0.0037018168,
-0.008190527,
0.018296964,
-0.03328214,
-0.017380064,
-0.008902151,
-0.008778986,
-0.0052311257,
-0.007622595,
0.01686003,
0.03191363,
0.0067091156,
0.000088685796,
0.010571732,
-0.027712308,
0.0084437,
0.0047555687,
-0.019131755,
0.031229375,
-0.011331255,
0.018803313,
-0.011762335,
0.007157302,
0.025769025,
-0.0076020677,
-0.026754351,
0.0106264725,
0.0103254,
0.00954535,
-0.016162092,
0.006904128,
0.0120976195,
-0.013041891,
0.00841633,
-0.018748574,
-0.0056964187,
0.016162092,
-0.00007088449,
-0.030025087,
-0.6336744,
-0.034595907,
-0.00046657605,
-0.00073172466,
0.021430852,
0.021170834,
0.010448567,
-0.029669276,
-0.0073762634,
0.008806355,
0.0050874325,
0.0008048544,
0.0005033547,
-0.016572645,
-0.00031646772,
-0.017174788,
0.008026306,
-0.036895003,
0.016983196,
0.0009904584,
-0.004485288,
-0.011577586,
-0.016627384,
-0.004984794,
0.0032707364,
0.014971488,
0.02591956,
-0.012248156,
0.0064183073,
0.02890291,
-0.009422185,
0.019186497,
0.024947919,
0.0016208278,
0.05961225,
0.0062609287,
-0.032105222,
0.019186497,
0.023401504,
0.038126662,
-0.017325323,
-0.021718238,
0.0145198805,
-0.006815175,
-0.04080894,
0.029149242,
0.018296964,
0.011037025,
-0.016668439,
-0.014930434,
0.0033049493,
0.019665474,
-0.019542309,
0.0030466432,
0.02887554,
0.025440583,
0.020842392,
-0.023784686,
0.0044031776,
0.00830685,
-0.0034092981,
0.01987075,
-0.018023264,
-0.04401125,
-0.018598037,
0.0019381508,
-0.02890291,
0.0006333631,
0.011119136,
-0.009969588,
0.02212879,
0.024865808,
-0.0040097316,
0.0068870215,
0.011529689,
0.01677792,
0.0030586177,
0.015710484,
-0.01677792,
0.02263514,
0.0015207556,
-0.007465217,
-0.032597885,
0.0058298483,
0.021020299,
0.010510149,
-0.00664069,
0.016818976,
-0.009996958,
-0.020076027,
0.020445524,
0.00047042497,
-0.031585187,
-0.029231353,
-0.024728958,
0.0068699154,
-0.01519045,
-0.018269595,
0.0006701418,
0.005395347,
-0.02653539,
0.00078389904,
-0.009045845,
0.0022067209,
0.024195239,
0.0060693375,
-0.017900098,
0.008395803,
0.04154793,
-0.010900174,
0.0001875285,
0.013069261,
0.0050395345,
-0.008717403,
0.010694898,
-0.027192274,
0.024756327,
0.0033990343,
0.010010643,
-0.025153195,
0.016600015,
-0.019720215,
-0.011666539,
-0.010024329,
0.0022460653,
0.015655743,
0.0060967077,
-0.015902074,
-0.0051148026,
0.008327377,
-0.010948072,
-0.0024770014,
0.009586406,
0.00026985287,
0.008026306,
0.0057956357,
0.01739375,
-0.000748831,
0.0024958183,
-0.035718083,
-0.01658633,
-0.007342051,
0.012193415,
0.026945943,
-0.019638104,
-0.0089568915,
-0.02034973,
0.0150262285,
-0.0073009958,
0.024318404,
0.012795559,
0.006767277,
0.0005756291,
0.011947083,
0.021800349,
-0.011283357,
-0.013815098,
-0.010393826,
-0.016285257,
-0.0034743021,
0.01215236,
0.0055082487,
-0.010523834,
0.005935908,
-0.013917737,
-0.016312627,
0.029094502,
0.006189082,
-0.010790694,
-0.019925492,
-0.00062908645,
-0.03202311,
-0.008936364,
0.01524519,
0.0030072986,
0.013349805,
-0.009750627,
0.012159202,
-0.026959628,
0.015546262,
-0.0016097088,
-0.004509237,
0.003828404,
-0.0034948299,
0.021512961,
0.016038926,
0.023278339,
0.014246179,
0.007725233,
0.03525279,
0.0038352464,
0.016449478,
-0.0010152626,
0.0316673,
-0.003664183,
-0.01814643,
0.024017332,
-0.004574241,
-0.0024752906,
0.024592107,
0.0006068482,
-0.0143556595,
0.020472895,
-0.03517068,
0.0009964457,
-0.012213943,
0.00026536244,
-0.015464152,
0.02530373,
0.0026343798,
0.006808332,
0.008457386,
-0.02123926,
-0.0009579563,
0.0069862385,
0.012145517,
0.013028205,
-0.0125287,
-0.02115715,
-0.017147418,
-0.01018855,
0.0048889983,
0.005959857,
-0.0004546016,
-0.037880328,
0.016873715,
0.0057340525,
0.029450314,
-0.0049266326,
0.0038865656,
0.0059701204,
0.010441723,
0.0005880312,
-0.0015737853,
0.018242225,
0.011160191,
0.020500265,
0.001838934,
0.05660153,
0.0028516306,
-0.0098737925,
0.03344636,
-0.0052311257,
0.014725157,
0.01903596,
0.019364402,
0.026234318,
0.026001671,
-0.012651865,
0.0067228004,
-0.018379075,
0.017051622,
-0.019460198,
-0.010551204,
0.0033066599,
-0.0018474872,
-0.0006260929,
0.026836462,
0.05342659,
0.023675205,
0.031804148,
-0.0017089256,
0.0076431227,
-0.014684102,
0.0012273815,
0.0067467494,
0.010510149,
0.004622139,
-0.021143464,
-0.010373298,
-0.006719379,
0.012282369,
0.022402493,
0.0006307971,
-0.0065380516,
-0.000025713001,
-0.0052242833,
0.010352771,
0.0017944574,
0.0015344407,
-0.020076027,
-0.018023264,
0.022758305,
0.011577586,
-0.0017474149,
-0.01809169,
-0.010571732,
-0.013869839,
-0.012768189,
0.016654754,
-0.022293013,
0.017174788,
0.013124001,
0.033090547,
0.0006427716,
-0.015601003,
-0.0054432447,
-0.00090065,
0.03174941,
0.0022135633,
-0.003099673,
0.0065448945,
-0.011673382,
-0.010777009,
0.030681971,
-0.011953926,
-0.007978408,
0.000545693,
0.0016148406,
0.001086254,
0.00002703607,
0.013486656,
-0.0043381737,
-0.004440812,
0.013192426,
0.038372993,
0.010961757,
0.0047384626,
0.0335011,
0.0072873104,
-0.025851134,
-0.019049644,
-0.009155326,
0.0026035884,
0.0397415,
0.014068273,
0.0051011173,
0.01839276,
0.014424085,
0.011611799,
-0.0076362803,
-0.0347875,
0.0066098985,
-0.015874704,
-0.018762259,
-0.007725233,
0.029121872,
0.014300919,
0.0017012277,
-0.0071641444,
-0.012809244,
-0.027383866,
-0.017804302,
0.0056211506,
0.022676194,
-0.013425074,
-0.008430015,
0.019720215,
0.021923514,
-0.0004982228,
0.015039914,
0.013315593,
0.009216908,
-0.010304873,
0.005682734,
-0.0117212795,
-0.0022751463,
0.008785828,
0.0071709873,
-0.02890291,
0.01363035,
0.029012391,
-0.023812057,
0.001067437,
0.021827718,
0.029368203,
0.013650877,
0.000034800756,
0.0032382344,
-0.028328136,
0.00013236048,
-0.0033066599,
-0.009675358,
-0.018515928,
0.014068273,
0.01583365,
-0.0039823614,
-0.012754504,
0.025563749,
-0.0022084315,
-0.0057853716,
0.011057553,
0.0142735485,
-0.014177754,
-0.0017670873,
-0.030052457,
0.04713145,
-0.023784686,
-0.008614765,
0.011105451,
-0.027055424,
-0.015053599,
-0.005159279,
0.006955447,
-0.012918725,
-0.020472895,
-0.0024718693,
0.015204135,
0.02416787,
0.013425074,
0.009052687,
-0.021677183,
-0.0057682656,
0.018160114,
-0.016805291,
-0.035663344,
0.0036026,
-0.03495172,
0.011173876,
0.012432904,
0.01131757,
-0.013130844,
-0.027507031,
0.022703564,
-0.015039914,
-0.024742642,
0.0250574,
-0.019049644,
-0.012248156,
-0.0036812893,
0.009689044,
0.017188473,
0.01105071,
-0.010222762,
-0.002110925,
-0.021950884,
0.0074036336,
-0.024715273,
0.011906029,
-0.021636127,
-0.009312704,
0.0031852047,
-0.019925492,
0.011194403,
0.012063406,
0.008293165,
-0.0077594463,
-0.0068972856,
0.0168874,
0.007923667,
0.0023812056,
0.017722191,
-0.0061309203,
-0.004084999,
0.0024051545,
0.0037873487,
0.027520716,
0.00591538,
-0.02742492,
0.021581387,
-0.008840568,
-0.010304873,
-0.03807192,
-0.005778529,
-0.018242225,
0.020609746,
0.022470918,
-0.023825742,
-0.04880103,
-0.0025180567,
0.0028482093,
0.0228541,
-0.015340986,
-0.012296054,
-0.017749561,
-0.005713525,
0.015258876,
-0.020828707,
0.0032895536,
-0.032433663,
-0.011461263,
0.025180565,
0.0024325247,
0.0022597504,
-0.009695887,
0.0063190903,
-0.013958792,
0.006527788,
-0.04119212,
-0.029888237,
0.0025710864,
0.013117159,
0.027096478,
0.007697863,
0.011906029,
-0.014369344,
0.019391773,
0.02669961,
-0.004368965,
0.000009909662,
-0.00007173981,
-0.0032228387,
-0.040617347,
0.029724015,
0.019980231,
0.0042115864,
0.006777541,
-0.006353303,
0.0206508,
0.0168874,
-0.01764008,
-0.013466128,
-0.0028533412,
-0.007855242,
-0.025632173,
0.0040986845,
-0.017886413,
0.010749638,
-0.029888237,
-0.006627005,
0.015778909,
0.0024051545,
0.015587318,
-0.025467953,
0.025385842,
-0.019555993,
0.021622442,
-0.0021554017,
0.023976278,
-0.007129932,
-0.010072227,
0.0045126583,
-0.0058811675,
0.0052961297,
-0.01295978,
0.0024821332,
0.0037394508,
-0.03218733,
-0.0023658099,
0.011707595,
-0.0027849157,
-0.00018132744,
-0.007095719,
-0.015778909,
-0.025727969,
-0.007957879,
-0.01586102,
-0.032789476,
0.002379495,
-0.00041290483,
-0.027753362,
0.022457233,
-0.02669961,
0.0060180184,
0.03954991,
0.00914164,
0.045981903,
-0.011173876,
0.0088747805,
0.0159705,
0.007040979,
-0.0026634606,
0.018187484,
-0.014944118,
0.002228959,
0.02739755,
0.029149242,
-0.01067437,
-0.04425758,
0.016818976,
0.038372993,
-0.018598037,
-0.0113449395,
0.034103245,
0.009990116,
0.008799513,
-0.012987151,
-0.013233482,
-0.015423097,
-0.011331255,
-0.021567702,
0.009565878,
-0.006654375,
-0.019022275,
-0.02357941,
0.008347905,
0.013035048,
0.02731544,
-0.007355736,
-0.02263514,
0.005935908,
-0.009086899,
-0.0038797231,
0.010571732,
-0.012597125,
0.020938188,
0.010516992,
0.0077594463,
0.011871816,
0.00010557833,
0.017243214,
0.0034007449,
0.0051250663,
0.032132592,
0.0014454876,
-0.017557971,
0.005111381,
0.005019007,
0.019391773,
-0.010099596,
0.00066629285,
-0.024099443,
-0.0061856606,
-0.0060727587,
0.016682126,
0.0088747805,
-0.019022275,
0.012562913,
-0.024345776,
-0.002454763,
-0.020938188,
0.004457918,
-0.009353759,
-0.027520716,
-0.03049038,
-0.0034229832,
-0.023305709,
0.029340833,
-0.007848399,
0.005487721,
-0.02123926,
-0.0015797726,
-0.038126662,
0.008484756,
0.003000456,
-0.014916748,
-0.019665474,
-0.0068870215,
-0.010530677,
-0.024181554,
0.010256975,
-0.02123926,
-0.014889378,
-0.012679236,
-0.019610735,
0.014451455,
0.014875693,
-0.004837679,
0.020431839,
0.0038112975,
0.006568843,
0.004054208,
0.0013035048,
0.000075214535,
0.0017944574,
0.009093742,
0.038400363,
-0.013507184,
-0.010113281,
-0.009962746,
-0.0007419885,
0.021554017,
-0.028081805,
-0.02034973,
-0.00019554711,
0.025043715,
-0.011324412,
-0.023935223,
0.025960615,
-0.008238425,
-0.021800349,
0.0038591954,
-0.0018645935,
-0.0025847715,
-0.026945943,
-0.018036949,
0.010612788,
-0.011167034,
-0.0015601002,
0.01970653,
-0.009319547,
-0.050662205,
-0.031256747,
0.013938264,
-0.026480649,
0.021294,
0.009935375,
-0.016463164,
-0.020363415,
-0.0018303808,
-0.04283433,
-0.008190527,
-0.014862007,
0.0079920925,
-0.010694898,
-0.00919638,
0.0019826274,
0.014547251,
-0.0054090316,
-0.00044006118,
-0.009634303,
0.006808332,
0.021896144,
-0.03503383,
0.035718083,
-0.0048034666,
-0.029012391,
-0.019720215,
0.018721202,
-0.02059606,
-0.018420132,
0.025276361,
0.003842089,
0.004091842,
0.01686003,
0.02277199,
0.0143556595,
0.013616664,
0.015505207,
-0.013212955,
-0.015436782,
0.012248156,
0.013808256,
-0.011242301,
0.0057545803,
0.023428874,
0.017161103,
0.011030182,
-0.013267695,
-0.04548924,
-0.0016020108,
-0.02282673,
0.015601003,
0.0138972085,
-0.013650877,
-0.0072599403,
0.004153425,
-0.023976278,
-0.015847335,
-0.0038215613,
-0.008662662,
-0.017735876,
0.013445601,
-0.0043758075,
0.0013984451,
-0.014930434,
0.023771001,
-0.014656732,
0.008758457,
-0.018994905,
-0.011844445,
0.0039994675,
0.035526495,
0.018680148,
0.009476925,
-0.020568691,
0.00049351854,
-0.01180339,
-0.00247358,
-0.0019398616,
-0.0135208685,
0.0056929975,
-0.0025471374,
-0.0070615066,
-0.009237436,
0.03035353,
-0.021636127,
-0.009032159,
-0.026603814,
0.009127955,
0.19213866,
-0.007321523,
0.020062342,
0.0098737925,
0.003753136,
-0.009647989,
-0.017845357,
0.009449555,
0.0037326084,
-0.01959705,
0.0020151294,
0.014205123,
-0.019460198,
0.0077662887,
0.005891431,
-0.001782483,
-0.01287767,
-0.009080057,
-0.018803313,
-0.0026087202,
0.03495172,
-0.019911805,
0.004553714,
0.001895385,
0.025509007,
0.0051524364,
-0.022293013,
0.02115715,
0.015710484,
-0.0075678546,
-0.018242225,
-0.0064593623,
-0.010031171,
0.007793659,
0.024236295,
0.0034298257,
-0.020664485,
-0.009620618,
0.006592792,
0.0066749025,
-0.0065448945,
0.016682126,
-0.0064251497,
0.0010263817,
-0.03656656,
0.0071230894,
0.0039720973,
-0.0074515315,
0.011009655,
0.014383029,
-0.029176611,
0.007082034,
0.009743785,
0.019159125,
-0.00803999,
-0.009962746,
0.016326312,
0.0051763854,
0.0007458374,
0.035526495,
-0.008375275,
0.019323347,
-0.014711472,
0.015765224,
-0.01572417,
0.009736941,
-0.02134874,
0.014643046,
0.017872728,
-0.0076773353,
0.00009782701,
-0.009504295,
-0.021731922,
0.017037937,
-0.01822854,
-0.023469929,
0.013144529,
0.011242301,
0.018187484,
0.012398692,
0.010393826,
0.0058332696,
-0.026918571,
-0.0228541,
-0.021499276,
-0.022320382,
0.016736865,
0.0073899487,
-0.024701588,
-0.0032245493,
0.020185508,
-0.0025368736,
-0.023141487,
-0.017900098,
-0.0010340796,
-0.008902151,
-0.015847335,
0.005966699,
-0.0023948906,
0.009045845,
-0.01099597,
0.06990344,
-0.0042492202,
-0.00046144414,
-0.032789476,
0.014164068,
-0.0027164903,
0.021964569,
0.0064627836,
0.0029747963,
0.0119676115,
-0.0056724697,
-0.003554702,
-0.018693833,
-0.012131833,
0.011878658,
0.010633315,
-0.010585417,
0.02455105,
-0.0106264725,
-0.0037120807,
-0.0136029795,
-0.014341975,
0.034623276,
-0.013192426,
-0.0014052877,
-0.03188626,
0.020719226,
-0.0097095715,
-0.027602827,
0.0023914694,
-0.002276857,
0.0092032235,
0.019282293,
0.0032279706,
0.007253098,
0.027958639,
-0.012863984,
-0.01217973,
0.031174636,
-0.011823918,
-0.0091211125,
0.017913783,
-0.00801262,
-0.009839579,
-0.015696798,
-0.0010503307,
0.010291188,
-0.00838896,
-0.020240247,
-0.020856077,
-0.032844216,
-0.022224586,
-0.009340074,
0.011331255,
-0.021170834,
-0.013596137,
-0.011290199,
0.017065307,
0.0016122747,
-0.014451455,
0.00027391562,
0.011563901,
-0.0051661213,
0.013240324,
-0.0008010054,
-0.17418383,
0.01895385,
0.029833496,
-0.028191285,
0.03177678,
0.02188246,
-0.015806278,
0.007868927,
-0.012740819,
0.007595225,
0.008984261,
0.015642058,
-0.0031783623,
-0.03057249,
0.026083782,
-0.010859119,
-0.012405534,
0.041657414,
0.025071084,
0.008265794,
0.0021742187,
-0.0078278715,
0.017078992,
-0.016764235,
0.010044856,
0.03188626,
-0.008423173,
-0.0062848777,
-0.01070174,
-0.028191285,
-0.027233329,
0.0048547857,
0.009086899,
-0.022210902,
0.036347598,
0.002134874,
0.0064969966,
-0.00095196906,
-0.0057340525,
0.012939253,
0.02717859,
-0.00059401843,
-0.01898122,
0.0055937804,
-0.035718083,
0.026042726,
0.023620466,
0.009408499,
0.020897133,
-0.017120048,
0.010017486,
0.0065620006,
0.023032006,
0.0197339,
0.032296814,
0.019993916,
0.014369344,
0.00919638,
-0.02653539,
-0.022607768,
0.0128502995,
-0.0013608112,
0.046419825,
-0.004646088,
0.0025283203,
-0.033336878,
0.0023829164,
0.0007791948,
-0.020719226,
0.015819965,
-0.010475936,
-0.011235459,
-0.0051045385,
-0.035362273,
0.0032433663,
0.011228616,
-0.023346763,
0.008936364,
-0.017120048,
0.01599787,
-0.007369421,
0.011262829,
-0.035800196,
-0.03320003,
-0.009880635,
-0.004769254,
0.008190527,
0.028410247,
-0.0030072986,
-0.0007723523,
0.031092525,
-0.019405458,
0.0060419673,
-0.041137382,
0.019802324,
0.01978864,
0.0072599403,
-0.0006667205,
0.0015575343,
-0.01836539,
0.021116095,
-0.008402646,
-0.019925492,
0.0020801337,
0.008505284,
0.016668439,
-0.01987075,
-0.021225575,
0.049156845,
-0.004481867,
-0.010660686,
-0.01750323,
0.0122071,
0.028547097,
-0.0136850905,
0.02218353,
0.005337185,
-0.0143556595,
-0.0026258267,
-0.023155171,
0.05030639,
0.010284346,
-0.0065106815,
0.00951798,
-0.02266251,
-0.033884283,
-0.14276285,
-0.008690032,
-0.0057648444,
0.020992927,
-0.0007261651,
-0.006917813,
-0.014287234,
0.025153195,
-0.0043621226,
0.014547251,
-0.0098737925,
-0.026330113,
0.0039139357,
0.00090492656,
0.028519727,
0.029942976,
-0.012590283,
0.013596137,
-0.0062575075,
0.021458222,
-0.01959705,
-0.01672318,
-0.000803999,
0.004280012,
0.018447502,
-0.007745761,
-0.005549304,
0.023209913,
0.0025129246,
0.015053599,
-0.0044647604,
-0.011324412,
0.031338856,
-0.01177602,
-0.012884513,
0.011502318,
-0.0018526191,
-0.0054124533,
0.011440735,
-0.010277502,
0.0019620997,
-0.013582452,
0.024783699,
0.0017739298,
0.032324184,
-0.008341063,
0.0106264725,
0.013384018,
0.008094731,
-0.009449555,
-0.0394678,
-0.024564737,
-0.016093666,
-0.0035307533,
0.030736713,
-0.036073897,
0.020555004,
0.04373755,
-0.014492511,
-0.009613776,
-0.0005076313,
0.0027062267,
-0.03673078,
-0.017667452,
0.015286245,
-0.01833802,
-0.025987986,
-0.029477684,
0.01911807,
-0.01962442,
-0.001325743,
0.0073352084,
0.0063567245,
0.012159202,
-0.03226944,
-0.0022494867,
-0.039850984,
-0.0197339,
0.02115715,
-0.011105451,
-0.0022819887,
-0.01594313,
0.028246026,
-0.020555004,
0.032707363,
0.008888466,
0.0069759744,
-0.0033887704,
-0.013698775,
-0.023114117,
-0.0206508,
-0.00220501,
-0.01027066,
-0.015094655,
-0.023374135,
0.025043715,
-0.0068425452,
-0.008156314,
0.03035353,
0.014588306,
-0.036895003,
-0.008648977,
-0.051264346,
0.0036436552,
0.0054671937,
0.008655819,
0.005898274,
-0.008436858,
0.02656276,
0.008669505,
-0.004673458,
0.009415342,
-0.03924884,
0.0030449326,
-0.020951873,
-0.017941153,
-0.012836615,
-0.023374135,
0.043628067,
-0.015327301,
0.014615676,
0.005682734,
-0.020527635,
0.00591538,
0.01989812,
0.014697786,
-0.035499122,
-0.0038215613,
-0.019022275,
0.011139663,
-0.029477684,
-0.013158214,
0.01102334,
-0.03621075,
-0.018994905,
-0.0041260547,
-0.02112978,
-0.006411465,
-0.021170834,
0.03517068,
0.014875693,
0.01180339,
-0.014656732,
-0.031831518,
0.01443777,
-0.02355204,
0.010763323,
0.021499276,
-0.043874398,
0.006336197,
0.011358624,
-0.018433817,
0.049622137,
0.012001824,
-0.005751159,
-0.038427733,
-0.0015772067,
-0.01758534,
-0.0073352084,
-0.006387516,
-0.013753516,
-0.035663344,
0.014068273,
0.022375122,
0.039358318,
0.023812057,
-0.01174865,
-0.010366456,
-0.013671405,
-0.017872728,
0.015696798,
-0.03826351,
-0.011659697,
-0.033090547,
0.013295065,
-0.0020561847,
-0.0076910206,
0.0041910587,
-0.010304873,
0.0074378466,
-0.0150262285,
0.02489318,
0.0039789397,
0.0018355127,
-0.02492055,
0.009415342,
0.011173876,
-0.0034161406,
-0.007082034,
-0.0048992625,
0.015984185,
-0.0031030942,
0.0062985625,
0.026521705,
0.010209077,
0.0040610502,
0.010120124,
0.022347752,
-0.011173876,
-0.021814033,
0.021636127,
0.01675055,
-0.0048547857,
0.0067741196,
0.013637193,
-0.031311486,
0.006880179,
0.008566867,
-0.02282673,
-0.030791452,
0.0031783623,
0.006216452,
-0.009210066,
0.001796168,
0.018543297,
0.0015772067,
0.008881624,
0.04584505,
-0.012836615,
0.011940241,
-0.017421119,
0.0491021,
0.035854936,
0.017749561,
0.0066783237,
0.01761271,
-0.007109404,
0.014478825,
0.023812057,
-0.0036436552,
0.020938188,
-0.013835626,
0.021184519,
-0.0145198805,
-0.028328136,
-0.027657567,
-0.0038318252,
-0.016312627,
0.036895003,
0.02433209,
-0.011057553,
0.08276743,
0.006213031,
-0.0014189727,
0.011119136,
-0.010537519,
0.020924503,
-0.012733976,
0.013664562,
0.006955447,
-0.039960463,
0.0065448945,
-0.0011709306,
0.022785675,
-0.020158138,
-0.014574621,
0.021335056,
0.0027267542,
0.00758154,
0.007506272,
-0.021075038,
0.030161938,
0.011201247,
0.018762259,
0.021745607,
-0.018105375,
-0.020555004,
0.010168022,
-0.01524519,
0.0014241047,
-0.04425758,
0.0044921306,
0.018940164,
-0.035088573,
-0.0021742187,
-0.0001961886,
-0.0073352084,
-0.029669276,
0.021252945,
0.020240247,
0.013828783,
-0.010277502,
0.009942218,
-0.040562607,
-0.0303809,
0.009559035,
0.009504295,
-0.012946095,
-0.02516688,
-0.0053919256
] |
Randomized trials may be designed and interpreted as single experiments or they may be seen in the context of other similar or relevant evidence. The amount and complexity of available randomized evidence vary for different topics. Systematic reviews may be useful in identifying gaps in the existing randomized evidence, pointing to discrepancies between trials, and planning future trials. A new, promising, but also very much debated extension of systematic reviews, mixed treatment comparison (MTC) meta-analysis, has become increasingly popular recently. MTC meta-analysis may have value in interpreting the available randomized evidence from networks of trials and can rank many different treatments, going beyond focusing on simple pairwise-compar | [
-0.021544868,
-0.006277319,
0.009986944,
-0.028092818,
-0.0059142774,
0.017122362,
-0.001912569,
-0.016422682,
-0.02427758,
-0.010396191,
-0.004006659,
0.017690027,
-0.0070496076,
-0.00004821646,
-0.0037063246,
0.011663536,
0.05518232,
0.02068677,
-0.007544664,
-0.011340098,
-0.029782612,
0.01930061,
-0.030099448,
-0.037677117,
0.01614545,
0.03860122,
0.028145624,
-0.039789356,
-0.0042310846,
-0.015221343,
0.017505204,
-0.0015668544,
-0.03432393,
-0.03989497,
-0.0076106717,
0.016343473,
0.004557822,
0.008521576,
-0.0005911802,
0.008085926,
0.029280953,
0.007927508,
0.007762489,
-0.023498692,
0.017214771,
-0.007221227,
0.008514975,
-0.02487165,
-0.020369934,
0.033030182,
0.011861559,
-0.011142076,
-0.021795696,
0.009313667,
-0.005534734,
-0.00733344,
-0.005029776,
0.024911253,
0.005858171,
-0.008277348,
-0.019353418,
0.0071354173,
-0.030073045,
0.027089503,
0.008534778,
-0.022257749,
0.000807355,
0.008072725,
0.013227915,
0.021624077,
0.014218029,
0.012752661,
-0.00036881724,
0.004706339,
0.036330562,
-0.02854167,
-0.011406107,
0.0024389795,
0.016422682,
-0.0010874745,
-0.025412912,
0.012204798,
-0.0056799506,
0.0070760106,
-0.0055017304,
0.0069769993,
0.0074786567,
-0.0112080835,
-0.020475546,
0.00829715,
-0.01257444,
0.013914394,
0.0010759232,
-0.006432437,
-0.014640477,
0.003920849,
-0.026152195,
0.039683744,
0.0045446204,
-0.0059835855,
-0.020039896,
0.009412678,
-0.025822157,
-0.0032541726,
-0.028647281,
-0.0025511922,
-0.00934007,
0.0055116313,
0.009049636,
-0.012376417,
-0.023683513,
0.026561443,
-0.024079558,
-0.016607502,
0.0083367545,
0.026482234,
0.016422682,
-0.02166368,
0.0009158549,
-0.007359843,
0.012231201,
-0.026997093,
0.03728107,
-0.018086072,
0.036330562,
-0.018548125,
-0.010706427,
-0.0020940898,
-0.0010618967,
0.003153511,
0.0031898154,
0.003719526,
0.0041089705,
0.036620993,
-0.03955173,
0.01623786,
-0.010983658,
0.004907662,
-0.035802502,
-0.027828788,
-0.009973742,
0.008983629,
0.01301009,
-0.023511892,
-0.012732859,
0.036805816,
0.02662745,
0.013439139,
-0.010845042,
-0.018732946,
0.01563059,
-0.029492179,
-0.0019752763,
0.009808724,
0.005491829,
-0.0023020136,
0.004330096,
0.015683396,
-0.028383251,
-0.009445682,
0.0040000584,
0.0009001781,
0.0068053794,
-0.0056337453,
0.018006863,
0.021346845,
0.019234603,
-0.020290725,
0.020488746,
-0.012416022,
-0.023591103,
0.03189485,
-0.021228032,
0.012594243,
-0.013069497,
-0.015128933,
0.006792178,
0.021069614,
-0.0011840106,
-0.0068779876,
0.016541494,
-0.016699912,
0.018719744,
-0.0047888486,
-0.014468857,
-0.010409392,
0.015656993,
0.0073136375,
-0.009947339,
-0.014112417,
0.004785548,
0.01239622,
-0.011769148,
-0.0006093323,
-0.6362073,
-0.0022838616,
0.019366618,
-0.03134039,
0.014006805,
0.023102647,
0.01353155,
0.015934225,
-0.0068515847,
0.024224775,
-0.009986944,
0.017188368,
0.025967374,
-0.041056704,
-0.013518348,
-0.026601046,
0.018917767,
-0.030521896,
0.029677,
-0.012297208,
-0.047974296,
0.01493091,
0.00035932867,
-0.0004855681,
-0.005646947,
0.000855623,
0.013874789,
-0.0014595921,
-0.009472085,
-0.0005944806,
-0.027828788,
0.0040297615,
0.000008076901,
-0.020831985,
0.045703635,
-0.018218087,
0.0093202675,
0.035036813,
-0.0039505525,
0.0028795798,
-0.019340215,
-0.0047987495,
0.028937714,
0.016092643,
-0.0112344865,
0.015326955,
-0.0021023408,
-0.0101189595,
-0.01684513,
-0.0034422942,
0.0045380197,
0.021452457,
-0.025346903,
-0.007676679,
0.015762605,
0.022191742,
0.007122216,
-0.023340274,
0.011749346,
0.010026548,
-0.011307095,
0.0013003489,
-0.024224775,
-0.023247862,
-0.016713114,
0.02584856,
-0.0013044744,
0.0032954274,
0.02235016,
0.00934007,
-0.0037855336,
0.011907764,
-0.010435795,
-0.027485548,
0.013036493,
0.010184967,
0.0043664,
-0.0027987205,
-0.023340274,
0.027538354,
0.0011427558,
0.00646214,
-0.0015156986,
-0.02436999,
0.037756324,
-0.0044852137,
0.0090298345,
0.009399476,
0.018534923,
0.027168712,
0.0034290927,
0.017333586,
0.009769119,
-0.018455714,
-0.009280663,
0.006963798,
0.028937714,
0.013557953,
0.0331622,
-0.031974062,
-0.031551614,
-0.0021699986,
0.0056799506,
-0.0068053794,
-0.025518524,
-0.0029703402,
-0.014574469,
-0.0029719905,
0.034112707,
0.010647019,
0.011062867,
0.005683251,
0.0063235243,
0.0071816226,
0.025122477,
-0.029043326,
-0.0009802122,
0.021241233,
-0.010151963,
-0.04757825,
0.04007979,
-0.019274207,
0.022812214,
-0.014864903,
-0.008779005,
0.0066469614,
0.011590928,
-0.027115906,
-0.015524978,
-0.01021137,
-0.018653737,
-0.03221169,
0.014732888,
-0.008838412,
0.010990259,
-0.0041617765,
0.0014348393,
-0.010851643,
-0.010250974,
-0.03778273,
-0.010343385,
-0.0002871329,
0.005178293,
0.007194824,
-0.011379704,
-0.017175168,
-0.011419308,
0.01117508,
-0.01362396,
0.012158592,
0.004808651,
-0.005316909,
-0.0018465616,
0.0073136375,
-0.0036106135,
-0.00480535,
-0.032317303,
-0.029835418,
-0.022402966,
-0.036330562,
0.023934342,
0.0077162837,
-0.023498692,
-0.019432627,
0.0007627999,
-0.027617563,
-0.024013551,
0.0029290854,
-0.00096453546,
-0.022944229,
0.004006659,
-0.031208375,
-0.0192214,
0.04213923,
-0.032449316,
0.027828788,
-0.010488601,
0.010501803,
-0.00620141,
0.0061420035,
-0.005135388,
-0.0031139066,
-0.0069043906,
0.000052909185,
0.01729398,
-0.0035941117,
0.019617448,
-0.016039837,
-0.016620703,
0.023973946,
0.00024876598,
0.0052542016,
-0.0067789764,
0.00077765156,
-0.0023597702,
0.0003417954,
-0.016818726,
0.017412795,
0.010158564,
0.042720094,
0.008237744,
-0.005594141,
0.002262409,
-0.025729747,
0.015300552,
-0.015775807,
0.015775807,
-0.0021765993,
0.0059406804,
0.0076964814,
-0.001971976,
-0.033241406,
-0.0025363406,
-0.019181797,
-0.0091354465,
0.025861762,
-0.00889782,
0.026086189,
0.004323495,
-0.00089440244,
0.003990157,
-0.019960687,
0.014482059,
0.0009901134,
-0.0077822916,
-0.01466688,
0.023089444,
0.00802652,
0.012442425,
-0.01868014,
-0.0066502616,
0.023287468,
-0.00023845231,
0.018204885,
0.048343938,
0.016858332,
0.0023680213,
-0.0066766646,
0.04295772,
0.009366473,
-0.008864815,
-0.0064489385,
0.009069439,
-0.004967069,
0.035776097,
-0.021703286,
0.019657051,
0.007762489,
0.014759291,
-0.00200663,
-0.013234516,
0.0044324077,
-0.01998709,
-0.018864961,
0.009894533,
-0.02689148,
0.025214888,
0.00768328,
0.04689177,
0.032766152,
-0.00157098,
0.021676883,
0.006838383,
-0.00062212127,
0.006075996,
-0.009386275,
-0.000733509,
-0.00012665201,
-0.0020940898,
-0.004706339,
0.0014892956,
-0.013069497,
0.005594141,
0.0037558302,
0.019577842,
0.0027261123,
0.008330154,
0.008977029,
-0.0070496076,
-0.00419148,
-0.023459086,
-0.018416109,
0.017082756,
0.021531666,
-0.001221965,
-0.031287584,
-0.010316982,
-0.01379558,
-0.029280953,
0.010264176,
-0.0027360134,
-0.017663622,
-0.012983687,
-0.009571096,
0.0064951438,
-0.023630707,
0.020752776,
0.009637103,
-0.0007099938,
-0.018693341,
0.00986153,
0.00041213472,
-0.000022741668,
-0.030970747,
0.03857482,
-0.0032112678,
-0.0174656,
-0.026931085,
-0.015353358,
-0.0041683773,
0.029412968,
-0.006415935,
-0.005333411,
-0.02166368,
0.027723175,
0.0065182466,
0.013821983,
0.016396279,
0.027881594,
0.017148765,
-0.0008506724,
-0.024964059,
-0.011802152,
0.019340215,
0.055974413,
0.020383134,
-0.013676766,
0.018534923,
-0.008607386,
0.00083334546,
-0.023736319,
-0.006148604,
0.027379936,
-0.004851556,
-0.005214597,
0.00072855846,
0.027115906,
0.0072872345,
-0.002103991,
0.026825473,
-0.002846576,
0.0074258507,
-0.012323611,
0.010666822,
0.018204885,
-0.00077600137,
0.030152254,
0.026772667,
0.027010294,
-0.014046409,
0.01937982,
0.027274324,
0.009920936,
-0.028488863,
0.007544664,
0.006006688,
-0.013122303,
0.020462343,
-0.008686595,
0.017412795,
-0.003940651,
0.006033091,
0.016422682,
-0.008627188,
0.006732771,
0.019604245,
0.013637162,
0.018204885,
0.0058548707,
-0.025082873,
-0.0015115731,
0.017888049,
0.010548009,
-0.0074060485,
-0.00689779,
0.014323641,
-0.016792323,
-0.014363245,
0.016026637,
-0.009828526,
-0.02121483,
0.008455569,
-0.033637453,
-0.0020000292,
-0.020145508,
-0.010429194,
0.020066299,
-0.013425938,
-0.022970632,
-0.008567781,
-0.029228147,
-0.0011765847,
-0.020964,
0.009122245,
-0.020792382,
-0.021188427,
-0.02304984,
0.007934108,
0.022746205,
0.0020775879,
0.009808724,
-0.009465484,
-0.014468857,
0.018468915,
-0.014812097,
0.0003106481,
-0.00968991,
-0.031393196,
-0.013109102,
0.0053994185,
-0.015379761,
-0.014548066,
-0.0027789182,
0.018099273,
0.0096107,
-0.013663565,
0.0041155713,
-0.010706427,
0.006171707,
0.009782321,
0.014825298,
0.00706941,
0.012462228,
-0.047604654,
0.0017756034,
-0.01213879,
-0.008798808,
-0.03289817,
-0.0034191916,
-0.018323699,
-0.017597616,
0.016673509,
0.012442425,
-0.013234516,
0.01631707,
-0.02479244,
0.019327013,
0.03466717,
0.01868014,
0.039076477,
-0.008924223,
0.01937982,
0.019247804,
-0.03466717,
-0.008792207,
0.0000124473245,
0.022402966,
-0.0052740043,
-0.014640477,
0.027274324,
-0.018838558,
-0.034878395,
-0.023696715,
0.0019637248,
-0.0045545218,
0.029360162,
-0.006488543,
-0.00855458,
-0.034191918,
-0.008521576,
-0.018046467,
0.009788921,
-0.016924338,
-0.0026683556,
0.012376417,
0.0071552196,
-0.01633027,
-0.011722943,
0.018574528,
-0.031076359,
-0.017690027,
0.01563059,
-0.022640593,
0.027617563,
0.012699855,
-0.013003489,
-0.015696598,
0.0049472665,
-0.01030378,
-0.030812329,
0.01082524,
-0.017227974,
0.051829137,
0.032000467,
0.03189485,
-0.026310613,
-0.012600843,
0.019564642,
0.006580954,
-0.0071090143,
0.011095871,
0.018402908,
-0.011419308,
0.011590928,
0.010719628,
-0.021597674,
0.017690027,
0.00541262,
0.023617506,
0.014561268,
-0.0069439956,
-0.018429311,
-0.00427729,
-0.023709916,
-0.0077888924,
0.013340128,
0.023538295,
0.0025214888,
-0.019406224,
0.009848328,
0.01780884,
0.009260861,
0.008422565,
0.013953999,
0.020119105,
-0.024422798,
0.0017624019,
-0.008462169,
0.005772361,
-0.021175226,
-0.0069769993,
-0.036700204,
0.0024571314,
0.013689968,
0.026587846,
0.020739576,
0.017650422,
0.010587613,
0.01283187,
-0.0058647715,
-0.024858447,
0.0056634485,
-0.00013036493,
-0.008072725,
-0.015089328,
0.0119275665,
-0.004445609,
-0.004604027,
0.0118747605,
0.031393196,
0.0011345049,
0.0109440535,
-0.038389996,
-0.0065446496,
-0.015247746,
-0.013175109,
0.033558242,
0.0022706601,
0.006755874,
0.009148648,
-0.0038449403,
-0.0056568477,
-0.011003461,
-0.008442367,
0.016752718,
0.03073312,
0.025030067,
0.015274149,
-0.0119803725,
0.017888049,
-0.0016807175,
-0.025412912,
-0.017703228,
0.013082699,
0.018310497,
-0.0016823676,
-0.020026693,
-0.008950626,
-0.021162024,
0.048264727,
-0.0070298053,
-0.010963856,
0.008752602,
-0.013062896,
-0.00497697,
0.050086536,
-0.004472012,
0.01895737,
-0.009637103,
0.0044324077,
-0.016039837,
-0.0020973901,
-0.009564496,
0.0091882525,
0.006514946,
0.033980694,
0.009148648,
-0.020501949,
0.026706658,
0.0033762867,
-0.0011031514,
-0.00794071,
-0.026403025,
0.040106192,
0.000175642,
0.01563059,
0.0053565134,
-0.012356616,
0.0058119656,
-0.011617331,
-0.00401326,
-0.029967433,
-0.020211516,
0.00045916508,
0.0062212124,
0.019947484,
-0.003937351,
-0.001545402,
0.0049010613,
-0.018719744,
-0.014112417,
-0.012739459,
0.009353272,
-0.01928741,
-0.019577842,
0.0011625582,
-0.024660425,
0.033241406,
0.0029092832,
0.0030181957,
0.003194766,
0.0070760106,
-0.015485373,
0.008085926,
0.011590928,
-0.00043606246,
-0.020858388,
0.007122216,
-0.017914452,
-0.026310613,
0.026482234,
-0.02751195,
-0.035908114,
-0.017043153,
-0.010138761,
0.004940666,
0.004782248,
-0.030891538,
-0.01265365,
0.0072608315,
0.0050858827,
-0.004831753,
-0.030416284,
0.021571271,
-0.031393196,
0.012805467,
0.03545926,
-0.016541494,
-0.008785606,
-0.02060756,
0.002820173,
0.010112358,
-0.040555045,
0.012204798,
-0.014442454,
0.028858505,
-0.0072674323,
-0.02034353,
0.016211458,
0.013584356,
-0.018125676,
-0.0074852575,
-0.0018086071,
0.005643646,
0.025122477,
-0.021162024,
0.0034257923,
0.0059043765,
-0.024053155,
-0.0041947803,
-0.0052542016,
0.004399404,
-0.015656993,
-0.029096132,
-0.01850852,
0.049901716,
0.015142134,
-0.012389619,
-0.02287822,
-0.012132189,
-0.046152487,
-0.015683396,
0.016805524,
0.017320383,
0.013557953,
0.021360047,
0.009947339,
0.00076321245,
-0.016726315,
-0.016963944,
0.0018746147,
0.006838383,
-0.009498488,
0.0070034023,
0.012957284,
-0.008805408,
-0.063948125,
-0.007676679,
0.035749696,
-0.020647164,
-0.0016510141,
-0.012686653,
0.0066568623,
0.019393021,
-0.017359989,
0.0016295617,
-0.011326897,
-0.011623931,
0.026165398,
-0.02557133,
-0.010151963,
0.0068845884,
-0.008151934,
-0.019313812,
0.0018168581,
0.002401025,
0.003003344,
-0.0051749926,
-0.014429253,
-0.015142134,
0.0072608315,
-0.018891364,
0.0063433265,
0.022336958,
0.013821983,
0.0027475648,
-0.017095959,
0.0023069642,
0.002059436,
0.007016604,
0.024739634,
-0.016079443,
0.034693573,
0.009155248,
-0.016633905,
-0.010323582,
0.012779064,
0.008369759,
-0.005917578,
0.005927479,
-0.006122201,
-0.0026502036,
0.021412853,
0.019696657,
0.004217883,
-0.0030809029,
-0.01631707,
-0.02235016,
0.0007714634,
-0.0047360426,
0.009584297,
-0.025294097,
0.03091794,
-0.015868217,
-0.019617448,
0.0012104136,
-0.0165811,
-0.009670108,
-0.022561384,
0.005168392,
0.1886232,
-0.023379877,
-0.027459145,
0.028647281,
0.005422521,
0.0002103991,
0.041531958,
0.01894417,
-0.0006233589,
0.009960541,
0.0235647,
0.002566044,
-0.013472144,
0.008831811,
-0.0007141193,
-0.015432567,
-0.014732888,
-0.03413911,
0.004478613,
-0.0023548198,
0.005082582,
0.013557953,
-0.0029802413,
0.0022277553,
-0.008838412,
0.008884618,
-0.007623873,
-0.013307124,
0.018996976,
-0.015670195,
-0.030231463,
-0.03379587,
0.001405136,
-0.007062809,
-0.008779005,
-0.009571096,
-0.01266025,
0.01930061,
0.025175283,
0.00035149025,
-0.0008737751,
0.025465718,
-0.0007157695,
-0.016013434,
0.026601046,
0.0069703986,
-0.00864699,
-0.004033062,
0.009049636,
-0.035934515,
-0.049188834,
0.0041947803,
0.01720157,
0.0044060047,
-0.006336726,
-0.009392876,
0.015709799,
-0.0062212124,
0.020594358,
0.0192082,
-0.022284152,
0.0028020209,
-0.02636342,
0.017650422,
0.00803312,
0.008673393,
-0.012495231,
0.020765979,
0.0010099157,
0.0060297907,
0.0064951438,
-0.0008638739,
-0.034455948,
0.0038053358,
-0.021690084,
-0.011227886,
0.055393543,
0.034772784,
0.004422507,
0.0087328,
-0.023683513,
-0.0034422942,
-0.0017376491,
0.012039779,
-0.009729515,
-0.02557133,
0.0041782786,
-0.003967054,
0.0060660946,
0.014218029,
-0.0042310846,
0.009841727,
-0.008514975,
-0.028224833,
0.033505436,
0.0076898807,
0.0025363406,
0.009729515,
-0.0034653968,
-0.025993777,
-0.0392877,
0.07778331,
-0.0007846649,
0.010541407,
0.042561676,
0.0063664294,
-0.016211458,
0.012112387,
0.008851614,
0.0043697003,
0.016977144,
-0.0497697,
0.015670195,
-0.001973626,
0.0019604245,
0.0109968595,
0.0042211837,
-0.034112707,
0.009333469,
-0.00864039,
0.006399433,
-0.025703344,
0.003851541,
0.026403025,
-0.019577842,
-0.0011930866,
0.013115702,
0.018468915,
0.0055050305,
-0.008323553,
-0.008594184,
-0.027023496,
0.0023251164,
0.035221633,
0.013062896,
-0.02436999,
0.007412649,
-0.031393196,
-0.0112344865,
0.018482117,
0.007326839,
0.027617563,
-0.0147460895,
-0.0039538527,
0.01868014,
0.0038581418,
-0.009683309,
0.013340128,
-0.016000234,
0.003943952,
0.026825473,
0.0005561137,
0.0015577785,
-0.011861559,
0.01196057,
-0.0061056996,
-0.0023548198,
-0.032977376,
0.005693152,
0.012290608,
-0.017650422,
0.006122201,
0.024660425,
-0.008950626,
-0.0049109627,
0.026389822,
-0.16528293,
0.010990259,
0.038997266,
0.0091618495,
0.02689148,
-0.0052674036,
0.036013726,
0.013993603,
-0.0014513412,
-0.0045710234,
0.0010165165,
0.008580983,
-0.0192214,
-0.029518582,
0.013062896,
-0.00034200167,
-0.008066124,
0.0111024715,
0.025769351,
0.027828788,
0.03152521,
-0.033479035,
0.03598732,
-0.019089386,
0.038469207,
0.025096074,
-0.008712998,
0.018191684,
-0.00995394,
-0.009947339,
-0.0091882525,
-0.002236006,
0.008508375,
-0.0057129543,
0.016633905,
0.008442367,
0.012627247,
0.004881259,
-0.031472404,
0.002278911,
0.023076244,
0.021175226,
0.0082839485,
-0.009353272,
0.0011452312,
0.021848502,
-0.011571125,
-0.027353533,
-0.0016196605,
0.005736057,
0.0012797216,
0.007491858,
0.01274606,
-0.010726228,
0.03675301,
0.023855133,
-0.00084448425,
-0.015392963,
0.0005796289,
-0.01754481,
0.0041287728,
-0.03281896,
0.04095109,
-0.024000349,
-0.0024389795,
-0.01824449,
-0.00384164,
-0.009379675,
-0.0077690897,
-0.005541335,
-0.028488863,
-0.00044060047,
-0.0068779876,
-0.01274606,
0.018429311,
0.026046583,
0.0091354465,
-0.025214888,
0.008917621,
0.00899683,
-0.0043003927,
0.003212918,
-0.007221227,
-0.00086222374,
0.001825109,
0.00016440009,
0.0066040563,
0.005788863,
-0.016831929,
-0.014350044,
0.018455714,
-0.003481899,
0.015181739,
-0.025729747,
0.011538122,
-0.0003370511,
-0.021412853,
-0.0043531987,
-0.005943981,
-0.042297646,
-0.004851556,
0.020462343,
-0.012409422,
0.011003461,
0.015762605,
0.00078796525,
-0.00030776026,
-0.0029884924,
0.03709625,
0.0021848502,
-0.028752893,
-0.008547979,
-0.004861457,
0.016752718,
-0.010046351,
0.027828788,
0.0015833564,
-0.031947657,
0.016567897,
-0.008891218,
0.0637897,
0.0008539728,
0.003597412,
0.025729747,
0.01510253,
-0.03395429,
-0.11913045,
-0.012224601,
0.013465542,
-0.006069395,
-0.01021797,
0.012944083,
-0.024752835,
0.020132305,
-0.00078879035,
0.0392877,
-0.0053829164,
-0.010746031,
0.0017376491,
-0.01589462,
0.02418517,
-0.021795696,
0.0054324223,
-0.037122652,
-0.0052343993,
0.04213923,
-0.001301174,
-0.00092905643,
-0.007894504,
-0.031419598,
0.00890442,
-0.0057129543,
-0.011511719,
0.0017904551,
0.005973684,
-0.00028176978,
0.018376505,
-0.0059340796,
0.0052343993,
-0.025412912,
-0.002821823,
0.01755801,
-0.025716545,
-0.02872649,
0.018099273,
-0.0069307936,
-0.010409392,
0.03989497,
0.046152487,
0.0006996801,
-0.0054258215,
-0.020911194,
-0.0038119366,
0.021531666,
-0.012864874,
0.0016831928,
-0.018376505,
-0.006844984,
-0.009300466,
-0.0017525008,
0.001798706,
0.013247717,
0.0056568477,
-0.004752544,
-0.008013318,
-0.0016625654,
-0.01937982,
-0.003239321,
-0.016858332,
0.031234778,
0.0046832366,
-0.024290781,
-0.014825298,
-0.020409537,
-0.0046304306,
-0.036647398,
0.0091882525,
0.009465484,
-0.027828788,
0.02216534,
-0.04609968,
0.0015074477,
-0.029307356,
-0.023102647,
0.022416167,
-0.01693754,
-0.012085984,
-0.001422463,
0.013135505,
-0.010501803,
0.026865076,
0.01326752,
-0.009472085,
-0.007062809,
-0.0067096683,
-0.036885023,
0.00986813,
0.029571388,
-0.0073400405,
-0.016699912,
-0.0071816226,
0.0043630996,
0.0056634485,
-0.022997035,
0.0235779,
0.014046409,
-0.013676766,
-0.040185403,
-0.038654026,
0.020620761,
0.0024604318,
-0.023643909,
0.022204943,
0.01799366,
0.04147915,
-0.012732859,
-0.0053730155,
0.0036634195,
-0.042720094,
-0.0045380197,
-0.0010849993,
-0.008765804,
-0.02166368,
-0.0059571825,
-0.010006746,
0.004577624,
0.022917826,
0.016383076,
-0.0075908694,
-0.0057921633,
0.031974062,
0.021716487,
-0.011538122,
-0.013597557,
0.0031667128,
-0.0023069642,
-0.028383251,
-0.012284007,
0.0030429484,
-0.010977058,
-0.009419279,
0.0005033077,
-0.014284036,
-0.015300552,
-0.0024092759,
0.03527444,
0.015287351,
0.030944344,
-0.016277464,
-0.019102588,
0.014944112,
-0.019709857,
-0.024488805,
0.000338495,
-0.052119568,
0.012099186,
-0.030495493,
-0.022891423,
0.026072986,
-0.0038581418,
-0.009472085,
-0.031287584,
-0.008198139,
0.011221285,
-0.0049373657,
0.00986153,
-0.013980402,
-0.028647281,
0.024000349,
0.01449526,
0.011947368,
0.013122303,
0.0030082946,
-0.0034785985,
-0.029096132,
0.029122535,
0.007227828,
-0.010957255,
-0.025412912,
0.0019884778,
-0.00802652,
0.023195056,
-0.006653562,
0.0014810447,
0.008013318,
0.013128904,
-0.00075207365,
0.003544606,
0.0060396916,
-0.0023729717,
-0.03677941,
-0.0050495784,
0.013993603,
-0.0031568117,
-0.031657226,
0.016369876,
-0.014152021,
0.0063235243,
0.031287584,
0.011340098,
-0.017148765,
0.0047459435,
-0.0006757524,
0.03736028,
-0.017835243,
0.013874789,
0.018627334,
0.04087188,
0.0023267665,
0.0006864786,
-0.0030280969,
-0.032422915,
-0.0023548198,
-0.021848502,
-0.02925455,
-0.011604129,
-0.007353242,
0.034376737,
0.0044324077,
-0.003920849,
0.0013655314,
-0.012198197,
-0.010963856,
0.008699796,
0.011386304,
-0.015828613,
-0.01631707,
-0.007254231,
-0.0043862024,
0.008594184,
0.030284269,
0.017782437,
0.012897877,
0.004877959,
0.04662774,
-0.038469207,
0.015749404,
0.01875935,
0.0029934428,
0.011709741,
-0.004521518,
-0.007551265,
0.007676679,
-0.052753244,
-0.008237744,
-0.003736028,
0.014020006,
0.05256842,
0.012323611,
0.006755874,
0.0005973684,
-0.009280663,
0.027115906,
0.015472172,
0.024964059,
0.01379558,
-0.020026693,
0.019762663,
0.018600931,
0.035802502,
-0.02759116,
-0.020409537,
0.030099448,
-0.016686711,
0.022917826,
-0.013993603,
0.0011320297,
0.03778273,
-0.0066832653,
0.033716664,
0.0007236079,
-0.00020070423,
-0.0072674323,
0.02174289,
-0.013208113,
-0.012614044,
0.00024340289,
-0.009049636,
0.0006790528,
-0.018468915,
-0.014165223,
0.019683454,
-0.014297238,
-0.00009158549,
-0.014548066,
0.017175168,
-0.010323582,
0.00881861,
-0.019234603,
0.0046832366,
-0.031181972,
-0.028092818,
0.0009934137,
-0.0092938645,
-0.0066568623,
-0.032422915
] |
The regulation and coordination of mitochondrial metabolism with hematopoietic stem cell (HSC) self-renewal and differentiation is not fully understood. Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted in hematopoietic failure due to changes in the cell cycle and a block in the differentiation of HSCs. Surprisingly, the HSC pool was increased by ∼40-fold in PTPMT1 knockout mice. Reintroduction of wild-type PTPMT1, but not catalytically deficient PTP | [
-0.0047654305,
-0.015027637,
0.009564256,
-0.029814832,
-0.03801658,
0.03801658,
-0.0077742976,
0.011574619,
-0.015228005,
-0.014653616,
0.02791801,
-0.0010719714,
0.006872639,
-0.0022925495,
-0.012389451,
0.0072600185,
0.03515799,
-0.006401773,
0.004164325,
0.016256563,
-0.029360663,
0.011527867,
-0.009290419,
-0.017111469,
0.027290188,
0.0077742976,
0.0143597415,
-0.029814832,
-0.0072666975,
-0.011648089,
0.017378626,
-0.009951635,
0.007801013,
-0.010265546,
-0.0016714071,
-0.014947489,
0.010345693,
-0.0297614,
0.01474712,
-0.013251036,
0.00029324763,
0.02149286,
-0.004625173,
-0.00037464732,
0.0061145783,
0.0004095031,
0.0023610087,
-0.0014343044,
-0.0186877,
0.031070475,
0.009464072,
-0.018019807,
0.009791341,
0.012796868,
-0.028479042,
-0.0039639566,
0.00080898777,
0.02365684,
-0.00547006,
0.011948641,
0.0111872405,
-0.012302625,
-0.027543988,
0.0071531553,
0.016750805,
-0.008963151,
-0.0057205204,
-0.0034429985,
-0.010339014,
0.010452556,
0.04709995,
-0.004698641,
-0.01856748,
-0.01596269,
0.019382311,
-0.032459695,
-0.022521418,
-0.0021021995,
-0.0048522567,
0.012396131,
0.030269,
-0.0059108706,
-0.018340396,
0.032245968,
0.008094887,
-0.0143196685,
-0.001253138,
0.006321626,
0.046886228,
0.0077809766,
0.020036848,
0.016430216,
0.0141193,
0.009310456,
-0.0062581757,
0.008729387,
-0.003235951,
0.021466143,
-0.012796868,
-0.026248273,
-0.028211884,
0.015789038,
-0.005019231,
-0.021639798,
-0.034944266,
-0.0025396706,
0.008094887,
-0.00042870507,
0.008248502,
0.008535698,
-0.018981574,
0.03304744,
-0.016777521,
-0.021719944,
0.015521879,
0.013464763,
-0.0016004433,
0.015762322,
-0.01398572,
-0.006946108,
0.029681252,
0.014666974,
0.015040995,
-0.012235836,
0.022361124,
0.015508521,
-0.003523146,
0.0021205666,
-0.010559419,
0.0038570934,
0.014520037,
-0.002028731,
0.0029337287,
-0.0061145783,
-0.027704284,
0.00053682056,
-0.0146269,
-0.032032244,
-0.034810685,
-0.044374943,
-0.013878858,
0.02250806,
0.009230308,
-0.0061012204,
0.0012740097,
0.01474712,
0.016603868,
-0.0014284604,
-0.007814371,
-0.006445186,
-0.0045316676,
-0.017418701,
0.014640258,
-0.01569553,
-0.0048756334,
0.0071397973,
0.012055504,
0.014239521,
-0.011815062,
-0.02944081,
-0.0015336538,
-0.039379086,
0.024845693,
-0.0044248044,
0.025900967,
0.020103639,
0.007420313,
0.015628742,
0.012643252,
-0.0148807,
0.012723399,
0.02580746,
-0.026114693,
0.023670198,
-0.021132197,
0.0035966143,
-0.011961998,
0.021599723,
-0.033181023,
-0.02320267,
0.0023359626,
0.015855826,
0.024845693,
0.008689313,
-0.00693275,
0.0052429754,
0.025259787,
-0.005616997,
0.0032459695,
-0.0024945878,
-0.0064318287,
-0.005600299,
-0.022160755,
-0.015989406,
-0.63775957,
-0.02269507,
0.020544449,
-0.0010193747,
0.010452556,
0.038951635,
0.017592354,
-0.018834637,
-0.025059419,
0.002345981,
-0.002766755,
0.025046062,
-0.007032934,
-0.020651313,
-0.020330723,
-0.024257945,
-0.014466605,
-0.019235374,
0.011287425,
0.0027133233,
-0.021706587,
0.0020120335,
-0.01704468,
0.016924458,
-0.001157963,
0.0022725125,
0.03611976,
0.023977429,
-0.0068392446,
0.027543988,
-0.0052296175,
0.025834177,
-0.026528789,
0.00731345,
0.049076922,
0.002486239,
-0.010065177,
0.03521142,
-0.011648089,
0.034570243,
-0.010392446,
0.012856978,
0.027116535,
0.013344541,
-0.0108132195,
0.011340857,
-0.005035928,
-0.014974205,
0.002073814,
-0.012476278,
0.011541225,
0.0018483993,
-0.015161215,
0.026128052,
-0.008101566,
0.0038203592,
0.017779363,
-0.006067826,
0.008535698,
0.007961308,
0.0035665592,
0.02556702,
0.0033661907,
-0.015869185,
-0.015294795,
0.018393828,
-0.00832865,
-0.0014084235,
-0.008402118,
-0.010612851,
0.0053498386,
0.0040407646,
-0.022628281,
0.01870106,
0.017405342,
-0.005957623,
0.015281437,
0.00036504635,
0.010826577,
-0.0030856747,
0.003154134,
-0.0026348457,
-0.016309995,
-0.0077676186,
0.04592446,
0.0048121833,
-0.020103639,
0.015722247,
0.0032142445,
0.037535697,
0.010325656,
0.0047453935,
0.007573929,
-0.04501612,
-0.020063564,
0.014105942,
-0.010011746,
0.014065868,
0.00445152,
-0.035077844,
-0.018246891,
-0.010819899,
0.0071064024,
-0.00832865,
0.02200046,
0.00858245,
-0.048489176,
-0.021599723,
0.0415965,
-0.016323352,
0.0130439885,
-0.0028602602,
-0.007680792,
0.009236988,
-0.009263704,
-0.016844312,
0.020678028,
0.0066555734,
-0.022801934,
-0.013117457,
0.0081817135,
-0.004999194,
0.014533395,
-0.0017398663,
0.020116996,
0.031524643,
0.014159373,
0.004311262,
-0.00011510753,
0.009063335,
-0.01291041,
-0.018994933,
0.033528328,
-0.036467064,
0.034356516,
-0.009303777,
0.013170889,
0.0075338553,
0.008796177,
-0.02416444,
-0.030242285,
-0.019863196,
-0.008034777,
0.00273336,
-0.002345981,
-0.011774988,
-0.011574619,
-0.004080838,
0.025005987,
0.0059041916,
-0.022748502,
-0.009744587,
-0.007467066,
0.0028736182,
0.006408452,
-0.014079226,
-0.020384155,
-0.01214233,
-0.009076692,
-0.024765546,
-0.010699677,
0.028986642,
0.0012539728,
0.017178258,
0.00046001267,
-0.016684016,
-0.0026515431,
0.0064318287,
-0.009243666,
-0.0059108706,
-0.0018868033,
-0.0004541686,
-0.0050325887,
-0.006759097,
-0.010539383,
0.008154998,
0.0025914325,
-0.013945647,
-0.022441272,
0.006034431,
0.012609857,
-0.03542515,
-0.011334178,
-0.0057772915,
0.016042838,
0.030990327,
0.028265314,
0.013511515,
0.0057372176,
0.046245046,
-0.003706817,
0.014239521,
-0.013785352,
0.0045316676,
0.020263933,
-0.017939659,
0.00833533,
0.009791341,
0.0047019804,
0.05025242,
0.015655458,
-0.02118563,
0.018554123,
-0.015228005,
0.015495163,
-0.023964072,
-0.015615384,
-0.011260709,
0.013571626,
0.015107784,
-0.017552279,
0.008382082,
-0.0080147395,
-0.017418701,
-0.00009235735,
-0.0072399816,
-0.015334869,
-0.0072600185,
-0.00068208773,
-0.022494702,
0.004528328,
-0.006468563,
-0.011808383,
-0.012376093,
0.012215799,
0.020931829,
0.02212068,
0.011881852,
-0.0025897627,
0.0058841547,
-0.0022374482,
0.0062615154,
0.005139452,
-0.00019515055,
0.0013165879,
0.019035006,
0.012803546,
-0.0017699216,
0.036093045,
0.013504836,
0.00032121575,
0.006448526,
-0.014506679,
-0.016176416,
-0.014199447,
-0.02340304,
0.02842561,
-0.010465914,
-0.019449102,
0.019248733,
-0.0062347995,
0.03256656,
-0.014760478,
0.00011197676,
0.022721786,
0.000351271,
-0.0049123676,
0.016777521,
0.010011746,
0.010960156,
0.0048489175,
-0.0008757773,
0.014867342,
-0.018099954,
-0.00017845319,
-0.0014977545,
0.028853063,
0.0057572545,
-0.005550207,
-0.003473054,
-0.032593273,
0.0035064486,
0.0053131045,
-0.029788116,
0.011801704,
-0.002810168,
0.038497467,
0.0006987851,
0.013104099,
0.0009626036,
0.0003865442,
-0.039085213,
0.029173652,
0.017966375,
-0.04189037,
-0.02035744,
-0.030910179,
-0.014292953,
-0.0047787884,
-0.002300898,
0.010445877,
-0.014479963,
-0.008949793,
0.009577614,
-0.03491755,
-0.0317918,
0.014279595,
-0.016056195,
0.023723628,
0.0061479732,
-0.0067490786,
0.00699286,
-0.027196683,
-0.0054533626,
0.04303915,
0.016189774,
-0.013538231,
-0.019195301,
-0.0061646705,
-0.026061261,
0.008615845,
-0.018607553,
0.012289267,
-0.004291225,
-0.0062648547,
-0.000040282415,
0.01297052,
0.023175955,
0.026702441,
0.0017632428,
-0.025994472,
-0.0094974665,
-0.015535237,
-0.023002302,
0.018206816,
0.048996776,
-0.0060878624,
0.005146131,
-0.021666512,
-0.0012439544,
0.0049424227,
-0.01780608,
0.025780745,
-0.009043298,
0.011454399,
-0.007927913,
-0.00591421,
0.015027637,
0.0034096038,
0.022668356,
-0.0071331183,
0.0019068401,
-0.0024127706,
-0.008034777,
0.011815062,
-0.02117227,
0.01990327,
0.037695993,
0.027837861,
0.016443575,
0.00915684,
0.01373192,
0.025099494,
-0.00076140027,
-0.012663289,
0.0015361584,
0.0065921233,
0.0034045945,
-0.012770152,
-0.040795024,
0.003414613,
0.019609395,
0.027944725,
0.0048622754,
0.015094426,
0.0073602027,
0.010652925,
0.008976508,
0.0039606174,
-0.006822547,
-0.0021573007,
0.014199447,
0.011935283,
-0.027250115,
0.038631044,
-0.005697144,
-0.030536158,
-0.009236988,
-0.0037802856,
0.009651083,
-0.0012113944,
-0.010038462,
-0.006899355,
0.012229157,
-0.011501151,
-0.026996315,
0.003994012,
0.0066989865,
-0.011608015,
0.016590511,
-0.0049824966,
-0.03497098,
-0.03187195,
-0.004551704,
0.017004605,
0.00065662427,
-0.037749425,
0.016497005,
0.009009903,
0.025794104,
0.012830262,
-0.028585905,
-0.008235145,
0.03515799,
-0.008382082,
-0.0111738825,
-0.006007715,
-0.03216582,
0.012128972,
-0.0017565638,
0.016590511,
-0.01297052,
-0.012776831,
0.016550437,
0.022467988,
-0.01569553,
-0.004775449,
0.016430216,
-0.018500691,
-0.00019661158,
0.0023927337,
0.030162137,
-0.0154684475,
0.015855826,
-0.006405113,
-0.03764256,
-0.024084292,
-0.024658682,
-0.0048021646,
-0.016857669,
0.011087056,
-0.002295889,
0.0043146014,
-0.015535237,
0.02912022,
0.0016371775,
-0.0006762437,
0.0033628512,
0.01773929,
0.025607092,
0.007026255,
0.015428374,
0.010986872,
0.0015311493,
-0.015682174,
-0.006879318,
0.023029018,
0.00046460444,
-0.018367112,
0.008495624,
-0.000928374,
-0.024725473,
-0.036039613,
-0.0040207277,
-0.007827729,
0.043439887,
-0.004464878,
-0.026421925,
-0.023990788,
-0.011167204,
-0.014199447,
0.001545342,
0.024818977,
-0.018407185,
-0.008936435,
-0.008342008,
-0.011467757,
-0.006518655,
0.017098112,
-0.035772454,
-0.0292538,
0.00794795,
0.011768309,
-0.0033561722,
-0.0060878624,
0.01093344,
-0.021639798,
-0.013070704,
-0.013197605,
-0.04635191,
-0.0039372407,
-0.018113311,
0.029681252,
0.04044772,
0.02059788,
-0.0038170198,
0.009397282,
0.0138655,
0.006415131,
-0.0009500806,
0.0021957047,
0.028639337,
-0.029227084,
0.021586366,
-0.0015904249,
-0.01628328,
0.029200368,
-0.0071731918,
0.014733763,
0.020557808,
-0.02404422,
-0.020998618,
0.015949331,
-0.0487029,
-0.026221557,
0.0143597415,
-0.019729618,
-0.022147397,
-0.03376877,
-0.024070935,
0.015976047,
-0.000287821,
0.0032326116,
0.0049056886,
0.0161497,
-0.022494702,
0.018901428,
-0.019021649,
0.01570889,
0.016710732,
-0.0161497,
0.0010736411,
-0.0071464763,
0.0070663285,
-0.012523031,
0.0016814256,
-0.000024980836,
-0.034570243,
0.014720405,
0.0146936895,
-0.021773376,
-0.008549056,
-0.021105481,
-0.026729157,
-0.005119415,
-0.00426117,
-0.012890372,
-0.017512206,
-0.0048956703,
0.00470532,
-0.023897283,
-0.003453017,
-0.0071999077,
-0.013551589,
0.03662736,
-0.012930446,
0.013892216,
-0.012042146,
0.03256656,
0.022174112,
0.0017014624,
-0.023576692,
-0.011621373,
-0.0040407646,
-0.0025647166,
0.04138277,
0.016830953,
0.00006647642,
-0.01990327,
0.00031077987,
0.0043212804,
-0.029414095,
-0.015187931,
-0.0035498617,
-0.018019807,
0.008622524,
-0.000024250327,
0.00006741565,
-0.027383694,
-0.0030255641,
-0.0043980884,
0.03980654,
-0.00056437124,
0.0013149182,
-0.021666512,
0.031230768,
-0.0017565638,
-0.0005627015,
0.010986872,
0.00058065116,
0.00046961365,
-0.016684016,
-0.02962782,
0.014426531,
-0.021973744,
0.020517733,
-0.01652372,
0.01093344,
0.011968678,
-0.0046652462,
0.006428489,
-0.02130585,
-0.007921235,
0.040581297,
0.0037235145,
-0.0022224204,
0.01119392,
0.005202902,
-0.006034431,
-0.010920083,
-0.0072199446,
-0.017538922,
-0.043092582,
0.013110778,
0.034810685,
0.009337172,
0.0034129433,
0.0029971786,
-0.027891293,
-0.023162598,
-0.035318285,
-0.02575403,
0.015602026,
-0.04998526,
-0.013117457,
-0.010719715,
0.013498157,
-0.0015344886,
0.0011070359,
-0.0006524499,
-0.018994933,
0.03785629,
-0.006939429,
0.039138645,
0.01233602,
0.0048288805,
-0.0181801,
-0.008054813,
-0.025794104,
-0.040741593,
0.019315522,
-0.022534776,
-0.03192538,
0.010853293,
-0.002309247,
0.012863657,
0.006415131,
0.008695993,
0.011053662,
0.0048522567,
0.02061124,
-0.0047220173,
0.0011972018,
0.009143482,
-0.04528328,
0.00061696797,
-0.0031558038,
0.00546672,
-0.026595578,
-0.018660985,
-0.018781206,
-0.009377246,
-0.008996545,
0.0031624828,
-0.0009659431,
0.0000053255494,
-0.009938277,
0.0047854674,
0.0019085099,
-0.0186877,
-0.0017949677,
0.00407082,
0.0038236987,
-0.0071197604,
-0.018527407,
0.0012690005,
0.00083528616,
0.015802395,
-0.016737448,
0.009744587,
0.0027450484,
-0.022801934,
-0.0043446566,
-0.00020015977,
-0.010559419,
0.031177336,
0.009711193,
0.000002093694,
-0.009838093,
0.008188392,
-0.049370795,
-0.03681437,
-0.0011370912,
0.009176876,
0.00093004375,
0.015268079,
-0.0048055043,
-0.018861353,
0.013304467,
0.020263933,
-0.0015111123,
-0.028265314,
0.01608291,
0.018473975,
0.012442883,
-0.0032476392,
-0.022027176,
-0.023990788,
0.02250806,
-0.005005873,
0.0020521074,
0.029788116,
-0.0047453935,
0.021532934,
-0.013351221,
0.008629203,
0.016697375,
-0.002232439,
0.010285582,
-0.03168494,
-0.0034797327,
0.007032934,
-0.005126094,
-0.015067711,
0.01220912,
-0.0053765546,
-0.009811377,
-0.005550207,
-0.007032934,
-0.007560571,
-0.00064744067,
-0.0076006446,
0.016617227,
0.015682174,
0.0033528327,
0.023923997,
0.016176416,
-0.004668586,
-0.012309304,
0.0017749309,
-0.0070863655,
-0.0013892215,
0.0025413404,
0.011995394,
-0.0115612615,
0.00909005,
0.0037903038,
-0.03491755,
-0.003847075,
-0.0049891756,
0.00826854,
-0.03096361,
0.027998157,
-0.018968217,
-0.012870336,
-0.0057138414,
-0.013651773,
-0.0052863886,
-0.014239521,
-0.0011654767,
-0.005239636,
-0.012222478,
-0.015495163,
-0.0018467295,
-0.008134961,
0.0035598802,
-0.003453017,
-0.01748549,
-0.0007814371,
0.044481806,
0.19470474,
0.0011529537,
0.0071598343,
0.0071531553,
0.016830953,
-0.0060444493,
0.007921235,
0.0029020037,
-0.005189544,
0.004605136,
0.01964947,
0.010318977,
-0.00044665477,
-0.007026255,
0.019916628,
-0.016323352,
-0.024191156,
-0.009530861,
-0.022240903,
-0.01271672,
-0.007026255,
-0.0062281205,
0.03523814,
0.00273503,
0.014573468,
0.010773146,
0.00037256017,
0.011875172,
0.014787194,
-0.0057772915,
-0.030883463,
0.019035006,
-0.020103639,
-0.01258982,
0.023349607,
-0.0018868033,
-0.027837861,
-0.0016054525,
0.00935053,
-0.0035765776,
-0.0077809766,
0.01652372,
0.002366018,
0.006308268,
-0.016136343,
0.022988945,
0.0055869413,
0.0031357668,
0.014386457,
-0.0066789496,
-0.06315615,
0.018968217,
0.035585444,
-0.0006666427,
-0.021786734,
0.0029904996,
0.009804698,
0.02842561,
0.0043847305,
0.023549976,
-0.009777983,
-0.00515281,
-0.008315292,
0.026969599,
-0.0010385767,
0.025981113,
-0.014199447,
-0.030242285,
0.023990788,
-0.014426531,
-0.0130439885,
-0.011233994,
0.004100875,
-0.0070930445,
-0.0036967986,
-0.03235283,
0.016323352,
0.019742975,
0.0018283625,
0.016951174,
0.006872639,
-0.019876555,
-0.023349607,
-0.002957105,
-0.0033745393,
-0.028024873,
0.03521142,
0.0058173654,
-0.029788116,
-0.016029479,
0.0128369415,
-0.0022842009,
-0.013584984,
0.018580837,
-0.004528328,
0.0018617572,
0.0034062644,
-0.004541686,
-0.014025794,
-0.03160479,
-0.03008199,
0.07758268,
0.0026732497,
0.013605021,
0.00495912,
-0.0021823468,
0.0007885335,
0.012262552,
-0.024912482,
-0.0032760247,
0.031043759,
-0.031204052,
0.0034363195,
0.0055869413,
-0.008889682,
0.017432058,
0.0044348226,
-0.0068325656,
0.021279134,
-0.0070997234,
0.004688623,
-0.024551818,
0.0033929064,
0.0395661,
-0.003700138,
-0.003726854,
-0.03243298,
-0.004207738,
-0.01608291,
-0.017699217,
-0.010465914,
-0.0023927337,
0.0027183325,
0.01760571,
-0.00273503,
0.0035698987,
0.00756725,
-0.0011020267,
-0.011334178,
0.03344818,
0.0020571165,
0.005540189,
-0.00826186,
0.017859511,
0.003973975,
-0.036734223,
0.015909258,
0.007460387,
-0.03598618,
-0.026555505,
-0.00073927623,
-0.014466605,
-0.0343298,
-0.0017006276,
0.012583141,
-0.015415016,
-0.012563105,
-0.04095532,
-0.0014034143,
0.011821741,
-0.02441824,
0.028345462,
-0.003199217,
0.007680792,
-0.0015077728,
-0.005940926,
-0.16830952,
-0.018073238,
0.036333486,
-0.0126566095,
0.029280515,
0.015815753,
0.0013399643,
-0.0019419047,
-0.0039439197,
-0.0010961826,
0.046592355,
0.0073468448,
-0.030028557,
-0.016630584,
-0.0053965915,
0.006091202,
-0.0066923075,
0.019622754,
0.020584524,
0.005049286,
0.03929894,
-0.012135652,
0.018166743,
-0.014306311,
0.011688162,
0.009524182,
0.01188853,
-0.007553892,
-0.0037435512,
-0.014132657,
-0.015268079,
0.0073535237,
0.01278351,
0.019368954,
0.013397973,
-0.00043538402,
0.018741133,
-0.018099954,
0.0085557345,
0.034890834,
0.027784431,
-0.0005455867,
0.0044615385,
0.0004883982,
0.006859281,
0.036413632,
-0.02129249,
0.0015253051,
0.028372178,
-0.0033428143,
0.027704284,
0.006892676,
0.002492918,
0.025633808,
0.018166743,
0.022227544,
0.0061880467,
-0.0074804234,
-0.0126566095,
0.008248502,
-0.0032793642,
-0.00921695,
0.013411331,
0.00007195525,
0.003237621,
-0.036520496,
0.017258406,
-0.0010385767,
-0.029788116,
0.013124136,
-0.027837861,
-0.010853293,
0.018099954,
-0.0052730306,
0.04827545,
0.0043847305,
0.003897167,
-0.0020253914,
0.000013005689,
0.026809303,
-0.01373192,
0.009651083,
-0.027891293,
-0.023256103,
-0.008094887,
0.02517964,
0.020170428,
0.014172731,
0.0009125115,
-0.017311838,
0.0039839935,
-0.03465039,
-0.0032827037,
-0.012676647,
0.03497098,
0.010786504,
-0.031123906,
-0.019462459,
0.010572777,
-0.0066121602,
0.011781667,
-0.011494473,
-0.004174344,
0.003509788,
0.035825886,
0.003045601,
-0.018981574,
-0.005603639,
0.04875633,
-0.004120912,
0.0014668644,
0.009617687,
0.012623215,
0.02797144,
-0.0019669507,
0.008916398,
0.017779363,
-0.022240903,
-0.004595117,
-0.0385509,
0.06502625,
0.004224436,
0.0021339245,
0.044134498,
0.020023491,
-0.023883924,
-0.13774666,
-0.03929894,
-0.0006562068,
0.015107784,
-0.0115612615,
0.0072533395,
-0.008809535,
0.01481391,
0.012543067,
0.027944725,
-0.011427683,
-0.014479963,
-0.0066288575,
-0.00040491132,
0.009103408,
-0.018594196,
0.016042838,
-0.022842009,
-0.023509903,
0.042023953,
0.0028251957,
-0.0048889914,
-0.005005873,
-0.009998388,
-0.00064702326,
0.0135983415,
-0.035345003,
0.033902347,
0.010900046,
0.02105205,
0.0045684017,
0.0063349837,
0.018914785,
-0.011307462,
-0.007847765,
0.0008782819,
0.008889682,
-0.013377937,
0.03326117,
0.008722709,
-0.015548595,
0.01787287,
0.019342238,
-0.00078310684,
0.005937586,
-0.006872639,
-0.02594104,
-0.0044081067,
0.009377246,
-0.008415476,
-0.0421041,
-0.0048789727,
-0.016697375,
0.00705965,
0.009183556,
-0.03708153,
0.022908797,
0.036493782,
-0.011901888,
-0.005536849,
0.01569553,
-0.009377246,
0.008362045,
0.01170152,
0.027891293,
-0.020277292,
-0.02155965,
-0.04528328,
0.02944081,
-0.023229387,
0.0021856863,
0.005182865,
-0.015014279,
-0.004037425,
-0.019035006,
-0.0076073236,
-0.013491479,
0.0037535697,
-0.0072199446,
-0.014186089,
-0.023002302,
-0.010225472,
0.004605136,
-0.010025104,
-0.003466375,
0.0026615614,
0.028906494,
0.015415016,
0.014960847,
0.001252303,
-0.006822547,
0.02741041,
-0.004150967,
-0.021987103,
0.005119415,
0.016163059,
0.013003915,
-0.008535698,
0.018046523,
0.033555042,
-0.016042838,
-0.038310457,
-0.057973284,
0.014867342,
-0.0044114464,
0.0025263126,
0.023630124,
-0.008301934,
0.0014535064,
-0.0067123445,
0.0033812183,
-0.005386573,
-0.010352372,
-0.001863427,
-0.007273376,
-0.008275218,
-0.011474435,
0.007921235,
0.021132197,
-0.018246891,
-0.0043479963,
0.01596269,
-0.003351163,
-0.018019807,
0.009430677,
0.009851451,
0.02428466,
-0.0115345465,
-0.00769415,
0.025900967,
-0.003897167,
0.007887839,
0.01220912,
-0.04571073,
-0.0161497,
-0.009911561,
-0.01723169,
-0.0062748734,
-0.0038504144,
0.023296177,
0.019422386,
0.027316904,
-0.006097881,
-0.017578995,
0.0038070013,
0.0018801243,
-0.0052964073,
0.017966375,
-0.020116996,
-0.004177683,
-0.003038922,
-0.005653731,
0.035505295,
0.0075271763,
-0.0067123445,
-0.024725473,
-0.024952555,
-0.014947489,
-0.0158959,
-0.0011471095,
-0.0049390835,
-0.019742975,
-0.0017148203,
0.0053398204,
0.014453247,
-0.015334869,
-0.013070704,
-0.0017749309,
-0.013658452,
0.013705205,
-0.012877015,
-0.027490556,
-0.03168494,
0.015642101,
0.010332335,
0.003439659,
0.009043298,
-0.007801013,
-0.011414325,
0.018393828,
-0.009764625,
0.017752647,
0.002454514,
0.011661446,
-0.031230768,
0.007847765,
0.02879963,
-0.0106328875,
-0.013691847,
0.034222938,
-0.009524182,
0.012529709,
-0.00054141233,
0.0054066097,
0.016603868,
-0.0017749309,
0.019355597,
0.029921694,
-0.0036467065,
-0.009490787,
-0.001888473,
0.05279042,
-0.011748273,
0.00034396592,
0.0030873446,
-0.018220175,
-0.0091100875,
0.031123906,
-0.045497004,
-0.04547029,
-0.013651773,
-0.010526025,
0.015000921,
0.012683325,
0.010853293,
0.00070796866,
-0.008495624,
-0.005493436,
-0.0027617456,
0.0012606517,
-0.002803489,
0.03529157,
0.02391064,
0.012349378,
-0.0094974665,
0.009183556,
0.019929986,
0.00013462258,
0.034810685,
-0.038871486,
0.038123444,
0.005162828,
0.020263933,
0.00839544,
-0.044428375,
-0.0146269,
-0.010913404,
-0.012563105,
0.0075806077,
0.027998157,
-0.004755412,
0.08276554,
-0.0009450714,
-0.02174666,
-0.014453247,
-0.0001633212,
0.016804237,
0.020678028,
0.015949331,
-0.022454629,
-0.0075204973,
0.025406724,
-0.028078305,
0.015187931,
-0.051855367,
-0.013184247,
0.011280746,
-0.0147070475,
0.0061847074,
0.016991248,
0.0048923306,
0.00909005,
-0.0028836366,
-0.0036901196,
0.03294058,
-0.02734362,
-0.010485951,
0.034356516,
-0.007921235,
0.011881852,
-0.026475357,
0.011694841,
-0.012523031,
-0.04947766,
0.0020253914,
0.013023952,
0.002110548,
-0.012469599,
-0.012770152,
0.022654997,
0.01201543,
-0.01870106,
0.0012756793,
-0.018113311,
-0.025460156,
-0.009470751,
-0.028826347,
0.00013566617,
-0.0005627015,
-0.0021923652
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.