Update app.py
Browse files
app.py
CHANGED
@@ -5,6 +5,8 @@ import matplotlib.pyplot as plt
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import random
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from scipy.stats import entropy as scipy_entropy
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import time
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st.set_page_config(layout="wide")
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@@ -31,7 +33,6 @@ def find_local_min_runs(profile, min_run=1, max_run=2):
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def bio_mutate(seq):
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r = random.random()
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mutation_type = "None"
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if r < 0.70:
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idx = random.randint(0, len(seq)-1)
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orig = seq[idx]
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@@ -43,31 +44,26 @@ def bio_mutate(seq):
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else:
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newbase = random.choice([b for b in bases if b != orig])
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seq = seq[:idx] + newbase + seq[idx+1:]
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mutation_type = f"Substitution at {idx}: {orig} → {newbase}"
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elif r < 0.80:
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idx = random.randint(0, len(seq)-1)
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ins = ''.join(random.choices(bases, k=random.randint(1, 3)))
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seq = seq[:idx] + ins + seq[idx:]
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if len(seq) > seqlen:
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seq = seq[:seqlen]
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mutation_type = f"Insertion at {idx}: {ins}"
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elif r < 0.90:
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if len(seq) > 4:
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idx = random.randint(0, len(seq)-2)
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dell = random.randint(1, min(3, len(seq)-idx))
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deleted = seq[idx:idx+dell]
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seq = seq[:idx] + seq[idx+dell:]
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mutation_type = f"Deletion at {idx}: {deleted}"
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else:
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if len(seq) > 10:
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start = random.randint(0, len(seq)-6)
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end = start + random.randint(3,6)
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subseq = seq[start:end]
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seq = seq[:start] + subseq
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mutation_type = f"Inversion from {start} to {end}: {subseq} → {subseq[::-1]}"
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while len(seq) < seqlen:
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seq += random.choice(bases)
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return seq[:seqlen]
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def compute_autocorr(profile):
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profile = profile - np.mean(profile)
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@@ -87,9 +83,6 @@ start = st.button("▶️ Старт эфира")
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stop = st.checkbox("⏹️ Остановить")
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plot_placeholder = st.empty()
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status_placeholder = st.sidebar.empty()
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entropy_placeholder = st.sidebar.empty()
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mutation_type_placeholder = st.sidebar.empty()
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if start:
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seq = ''.join(random.choices(bases, k=seqlen))
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@@ -103,9 +96,7 @@ if start:
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break
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if step != 0:
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seq
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else:
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mut_type = "Initial sequence"
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torsion_profile = np.array([ANGLE_MAP.get(nt, 0.0) for nt in seq])
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runs = find_local_min_runs(torsion_profile, min_run, max_run)
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@@ -135,9 +126,5 @@ if start:
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plot_placeholder.pyplot(fig)
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plt.close(fig)
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status_placeholder.markdown(f"### ℹ️ Шаг: {step}")
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entropy_placeholder.metric("Энтропия", f"{ent:.2f}")
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mutation_type_placeholder.markdown(f"**Мутация:** {mut_type}")
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step += 1
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time.sleep(0.3)
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import random
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from scipy.stats import entropy as scipy_entropy
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import time
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import imageio
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from datetime import datetime
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st.set_page_config(layout="wide")
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def bio_mutate(seq):
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r = random.random()
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if r < 0.70:
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idx = random.randint(0, len(seq)-1)
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orig = seq[idx]
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else:
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newbase = random.choice([b for b in bases if b != orig])
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seq = seq[:idx] + newbase + seq[idx+1:]
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elif r < 0.80:
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idx = random.randint(0, len(seq)-1)
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ins = ''.join(random.choices(bases, k=random.randint(1, 3)))
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seq = seq[:idx] + ins + seq[idx:]
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if len(seq) > seqlen:
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seq = seq[:seqlen]
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elif r < 0.90:
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if len(seq) > 4:
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idx = random.randint(0, len(seq)-2)
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dell = random.randint(1, min(3, len(seq)-idx))
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seq = seq[:idx] + seq[idx+dell:]
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else:
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if len(seq) > 10:
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start = random.randint(0, len(seq)-6)
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end = start + random.randint(3,6)
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subseq = seq[start:end][::-1]
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seq = seq[:start] + subseq + seq[end:]
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while len(seq) < seqlen:
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seq += random.choice(bases)
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return seq[:seqlen]
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def compute_autocorr(profile):
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profile = profile - np.mean(profile)
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stop = st.checkbox("⏹️ Остановить")
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plot_placeholder = st.empty()
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if start:
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seq = ''.join(random.choices(bases, k=seqlen))
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break
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if step != 0:
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seq = bio_mutate(seq)
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torsion_profile = np.array([ANGLE_MAP.get(nt, 0.0) for nt in seq])
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runs = find_local_min_runs(torsion_profile, min_run, max_run)
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plot_placeholder.pyplot(fig)
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plt.close(fig)
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step += 1
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time.sleep(0.3)
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